{"concept_id": "C0000184", "aliases": [], "types": ["T116", "T126"], "definition": "Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-.", "canonical_name": "cyclic 2',3'-nucleotide phosphodiesterase"}
{"concept_id": "C0001216", "aliases": ["acrosome", "acrosomal vesicle"], "types": ["T026"], "definition": "The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.", "canonical_name": "acrosomal granule"}
{"concept_id": "C0001272", "aliases": [], "types": ["T043"], "definition": "Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.", "canonical_name": "action potential"}
{"concept_id": "C0001349", "aliases": [], "types": ["T046"], "definition": "An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.", "canonical_name": "acute-phase response"}
{"concept_id": "C0001801", "aliases": [], "types": ["T044"], "definition": "The clumping together of suspended material resulting from the action of AGGLUTININS.", "canonical_name": "agglutination"}
{"concept_id": "C0001807", "aliases": ["aggression"], "types": ["T055"], "definition": "Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.", "canonical_name": "aggressive behavior"}
{"concept_id": "C0001811", "aliases": ["ageing"], "types": ["T040"], "definition": "The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.", "canonical_name": "aging"}
{"concept_id": "C0002451", "aliases": ["amelogenesis"], "types": ["T042"], "definition": "The elaboration of dental enamel by ameloblasts, beginning with its participation in the formation of the dentino-enamel junction to the production of the matrix for the enamel prisms and interprismatic substance. (Jablonski, Dictionary of Dentistry, 1992).", "canonical_name": "enamel development"}
{"concept_id": "C0002511", "aliases": [], "types": ["T044"], "definition": "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. [GOC:jl]", "canonical_name": "amino acid activation"}
{"concept_id": "C0002788", "aliases": [], "types": ["T043"], "definition": "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]", "canonical_name": "mitotic anaphase"}
{"concept_id": "C0003261", "aliases": ["immunoglobulin production"], "types": ["T038"], "definition": "The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.", "canonical_name": "antibody production"}
{"concept_id": "C0003272", "aliases": ["antibody-dependent cellular cytotoxicity", "antibody-dependent cell killing", "antibody-dependent cell death", "type VI hypersensitivity", "antibody dependent cell killing", "antibody dependent cell death"], "types": ["T043"], "definition": "The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a \"killer\" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.", "canonical_name": "ADCC"}
{"concept_id": "C0003319", "aliases": [], "types": ["T044"], "definition": "Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)", "canonical_name": "antigenic variation"}
{"concept_id": "C0003622", "aliases": [], "types": ["T040"], "definition": "Physiologic mechanisms which regulate or control the appetite and food intake.", "canonical_name": "regulation of appetite"}
{"concept_id": "C0004372", "aliases": [], "types": ["T043"], "definition": "The spontaneous disintegration of tissues or cells by the action of their own autogenous enzymes.", "canonical_name": "autolysis"}
{"concept_id": "C0004391", "aliases": [], "types": ["T043"], "definition": "The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]", "canonical_name": "autophagy"}
{"concept_id": "C0004461", "aliases": [], "types": ["T026"], "definition": "Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.", "canonical_name": "axon"}
{"concept_id": "C0004462", "aliases": ["axoplasmic transport", "axonal transport"], "types": ["T043"], "definition": "The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)", "canonical_name": "axon cargo transport"}
{"concept_id": "C0004799", "aliases": [], "types": ["T024"], "definition": "A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.", "canonical_name": "basement membrane"}
{"concept_id": "C0004927", "aliases": ["behavioural response to stimulus", "behavior", "behavioral response to stimulus"], "types": ["T053"], "definition": "The observable response of a man or animal to a situation.", "canonical_name": "behaviour"}
{"concept_id": "C0005528", "aliases": [], "types": ["T043"], "definition": "The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.", "canonical_name": "transport"}
{"concept_id": "C0005615", "aliases": ["giving birth"], "types": ["T040"], "definition": "The process of giving birth to one or more offspring.", "canonical_name": "parturition"}
{"concept_id": "C0005775", "aliases": [], "types": ["T039"], "definition": "The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.", "canonical_name": "blood circulation"}
{"concept_id": "C0005778", "aliases": ["blood clotting"], "types": ["T042"], "definition": "The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.", "canonical_name": "blood coagulation"}
{"concept_id": "C0005905", "aliases": ["thermoregulation"], "types": ["T040"], "definition": "The processes of heating and cooling that an organism uses to control its temperature.", "canonical_name": "temperature homeostasis"}
{"concept_id": "C0005939", "aliases": [], "types": ["T042"], "definition": "The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.", "canonical_name": "bone development"}
{"concept_id": "C0005972", "aliases": [], "types": ["T042"], "definition": "Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.", "canonical_name": "bone regeneration"}
{"concept_id": "C0005974", "aliases": [], "types": ["T042"], "definition": "Bone loss due to osteoclastic activity.", "canonical_name": "bone resorption"}
{"concept_id": "C0006549", "aliases": ["C-fibre"], "types": ["T023"], "definition": "The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated. [NIF_Subcellular:nlx_subcell_20090210]", "canonical_name": "C-fiber"}
{"concept_id": "C0006660", "aliases": [], "types": ["T042"], "definition": "Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.", "canonical_name": "biomineral tissue development"}
{"concept_id": "C0007577", "aliases": [], "types": ["T043"], "definition": "Adherence of cells to surfaces or to other cells.", "canonical_name": "cell adhesion"}
{"concept_id": "C0007580", "aliases": [], "types": ["T043"], "definition": "The phenomenon by which dissociated cells intermixed in vitro tend to group themselves with cells of their own type.", "canonical_name": "cell aggregation"}
{"concept_id": "C0007581", "aliases": [], "types": ["T043"], "definition": "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. [GOC:BHF, PMID:28682291]", "canonical_name": "cellular senescence"}
{"concept_id": "C0007582", "aliases": [], "types": ["T043"], "definition": "Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.", "canonical_name": "cell communication"}
{"concept_id": "C0007586", "aliases": ["cell-division cycle"], "types": ["T043"], "definition": "The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.", "canonical_name": "cell cycle"}
{"concept_id": "C0007587", "aliases": [], "types": ["T043"], "definition": "The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.", "canonical_name": "cell death"}
{"concept_id": "C0007589", "aliases": [], "types": ["T043"], "definition": "Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.", "canonical_name": "cell differentiation"}
{"concept_id": "C0007590", "aliases": [], "types": ["T043"], "definition": "The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.", "canonical_name": "cell division"}
{"concept_id": "C0007591", "aliases": ["M-phase"], "types": ["T043"], "definition": "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase. [GOC:mtg_cell_cycle]", "canonical_name": "M phase"}
{"concept_id": "C0007595", "aliases": ["cell growth", "cellular growth", "growth of cell"], "types": ["T043"], "definition": "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. [GOC:ai]", "canonical_name": "cell expansion"}
{"concept_id": "C0007603", "aliases": ["cellular membrane", "cytoplasmic membrane", "plasma membrane lipid bilayer", "plasmalemma", "cell membrane"], "types": ["T026"], "definition": "The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.", "canonical_name": "plasma membrane"}
{"concept_id": "C0007608", "aliases": ["cell locomotion", "cell motility"], "types": ["T043"], "definition": "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]", "canonical_name": "movement of a cell"}
{"concept_id": "C0007609", "aliases": [], "types": ["T026"], "definition": "Within most types of eukaryotic CELL NUCLEUS, a distinct region, not delimited by a membrane, in which some species of rRNA (RNA, RIBOSOMAL) are synthesized and assembled into ribonucleoprotein subunits of ribosomes. In the nucleolus rRNA is transcribed from a nucleolar organizer, i.e., a group of tandemly repeated chromosomal genes which encode rRNA and which are transcribed by RNA polymerase I. (Singleton & Sainsbury, Dictionary of Microbiology & Molecular Biology, 2d ed)", "canonical_name": "nucleolus"}
{"concept_id": "C0007610", "aliases": ["cell nucleus"], "types": ["T026"], "definition": "Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)", "canonical_name": "nucleus"}
{"concept_id": "C0007623", "aliases": [], "types": ["T026"], "definition": "The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.", "canonical_name": "cell wall"}
{"concept_id": "C0007637", "aliases": ["inclusion body"], "types": ["T026"], "definition": "A generic term for any circumscribed mass of foreign (e.g., lead or viruses) or metabolically inactive materials (e.g., ceroid or MALLORY BODIES), within the cytoplasm or nucleus of a cell. Inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells. (Stedman, 25th ed)", "canonical_name": "cellular inclusion"}
{"concept_id": "C0007708", "aliases": [], "types": ["T026"], "definition": "Self-replicating, short, fibrous, rod-shaped organelles. Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder.", "canonical_name": "centriole"}
{"concept_id": "C0007709", "aliases": [], "types": ["T026"], "definition": "The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.", "canonical_name": "centromere"}
{"concept_id": "C0008018", "aliases": ["taxis in response to chemical stimulus", "chemotaxis"], "types": ["T043"], "definition": "The movement of cells or organisms toward or away from a substance in response to its concentration gradient.", "canonical_name": "chemotropism"}
{"concept_id": "C0008019", "aliases": ["immune cell chemotaxis", "leucocyte chemotaxis"], "types": ["T043"], "definition": "The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.", "canonical_name": "leukocyte chemotaxis"}
{"concept_id": "C0008266", "aliases": [], "types": ["T026"], "definition": "Plant cell inclusion bodies that contain the photosynthetic pigment CHLOROPHYLL, which is associated with the membrane of THYLAKOIDS. Chloroplasts occur in cells of leaves and young stems of plants. They are also found in some forms of PHYTOPLANKTON such as HAPTOPHYTA; DINOFLAGELLATES; DIATOMS; and CRYPTOPHYTA.", "canonical_name": "chloroplast"}
{"concept_id": "C0008503", "aliases": [], "types": ["T018"], "definition": "The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.", "canonical_name": "egg chorion"}
{"concept_id": "C0008537", "aliases": [], "types": ["T026"], "definition": "Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.", "canonical_name": "chromaffin granule"}
{"concept_id": "C0008545", "aliases": [], "types": ["T026"], "definition": "Either of the two longitudinally adjacent threads formed when a eukaryotic chromosome replicates prior to mitosis. The chromatids are held together at the centromere. Sister chromatids are derived from the same chromosome. (Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)", "canonical_name": "chromatid"}
{"concept_id": "C0008633", "aliases": [], "types": ["T026"], "definition": "In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)", "canonical_name": "chromosome"}
{"concept_id": "C0008778", "aliases": ["microtubule-based flagellum", "eukaryotic flagellum"], "types": ["T026"], "definition": "Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)", "canonical_name": "cilium"}
{"concept_id": "C0008810", "aliases": ["circadian process"], "types": ["T040"], "definition": "The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.", "canonical_name": "circadian rhythm"}
{"concept_id": "C0008858", "aliases": ["TCA cycle", "Krebs cycle", "tricarboxylic acid cycle"], "types": ["T044"], "definition": "A series of oxidative reactions in the breakdown of acetyl units derived from GLUCOSE; FATTY ACIDS; or AMINO ACIDS by means of tricarboxylic acid intermediates. The end products are CARBON DIOXIDE, water, and energy in the form of phosphate bonds.", "canonical_name": "citric acid cycle"}
{"concept_id": "C0009240", "aliases": [], "types": ["T041"], "definition": "Intellectual or mental process whereby an organism obtains knowledge.", "canonical_name": "cognition"}
{"concept_id": "C0009528", "aliases": ["complement response", "complement cascade"], "types": ["T044"], "definition": "The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.", "canonical_name": "complement activation"}
{"concept_id": "C0009546", "aliases": ["complement cascade, alternative pathway"], "types": ["T044"], "definition": "Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.", "canonical_name": "complement activation, alternative pathway"}
{"concept_id": "C0009649", "aliases": ["Pavlovian conditioning", "associative learning", "conditional learning", "conditional response"], "types": ["T041"], "definition": "Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.", "canonical_name": "classical conditioning"}
{"concept_id": "C0009651", "aliases": ["instrumental conditioning"], "types": ["T041"], "definition": "Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced.", "canonical_name": "operant conditioning"}
{"concept_id": "C0009835", "aliases": [], "types": ["T043"], "definition": "Arrest of cell locomotion or cell division when two cells come into contact.", "canonical_name": "contact inhibition"}
{"concept_id": "C0009964", "aliases": [], "types": ["T054"], "definition": "The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)", "canonical_name": "cooperative behavior"}
{"concept_id": "C0009990", "aliases": [], "types": ["T054"], "definition": "Sexual union of a male and a female in non-human species.", "canonical_name": "copulation"}
{"concept_id": "C0010096", "aliases": [], "types": ["T042"], "definition": "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy. [PMID:10617764]", "canonical_name": "luteolysis"}
{"concept_id": "C0010813", "aliases": ["cytokinesis", "cytokinesis involved in cell cycle"], "types": ["T043"], "definition": "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. [GOC:mtg_cell_cycle]", "canonical_name": "cell cycle cytokinesis"}
{"concept_id": "C0010834", "aliases": [], "types": ["T026"], "definition": "The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)", "canonical_name": "cytoplasm"}
{"concept_id": "C0010839", "aliases": [], "types": ["T043"], "definition": "The movement of CYTOPLASM within a CELL. It serves as an internal transport system for moving essential substances throughout the cell, and in single-celled organisms, such as the AMOEBA, it is responsible for the movement (CELL MOVEMENT) of the entire cell.", "canonical_name": "cytoplasmic streaming"}
{"concept_id": "C0010853", "aliases": [], "types": ["T026"], "definition": "The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.", "canonical_name": "cytoskeleton"}
{"concept_id": "C0010985", "aliases": [], "types": ["T042"], "definition": "Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.", "canonical_name": "dark adaptation"}
{"concept_id": "C0011107", "aliases": ["decidualization"], "types": ["T040"], "definition": "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. [ISBN:0721662544, PMID:11133685]", "canonical_name": "decidual cell reaction"}
{"concept_id": "C0011135", "aliases": [], "types": ["T040"], "definition": "The normal process of elimination of fecal material from the RECTUM.", "canonical_name": "defecation"}
{"concept_id": "C0011305", "aliases": [], "types": ["T026"], "definition": "Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS.", "canonical_name": "dendrite"}
{"concept_id": "C0011435", "aliases": ["dentine development", "dentinogenesis"], "types": ["T042"], "definition": "The formation of dentin. Dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately. Formation progresses from the tip of the papilla over its slope to form a calcified cap becoming thicker by the apposition of new layers pulpward. A layer of uncalcified dentin intervenes between the calcified tissue and the odontoblast and its processes. (From Jablonski, Dictionary of Dentistry, 1992)", "canonical_name": "dentin development"}
{"concept_id": "C0011703", "aliases": ["desmosome", "macula adherens"], "types": ["T026"], "definition": "A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)", "canonical_name": "spot desmosome"}
{"concept_id": "C0012154", "aliases": [], "types": ["T039"], "definition": "A phase of the ESTROUS CYCLES that follows METESTRUS. Diestrus is a period of sexual quiescence separating phases of ESTRUS in polyestrous animals.", "canonical_name": "diestrus"}
{"concept_id": "C0012238", "aliases": [], "types": ["T040"], "definition": "The process of breakdown of food for metabolism and use by the body.", "canonical_name": "digestion"}
{"concept_id": "C0012797", "aliases": [], "types": ["T042"], "definition": "An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)", "canonical_name": "diuresis"}
{"concept_id": "C0012899", "aliases": [], "types": ["T045"], "definition": "The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as \"dark repair\" because they do not require light.", "canonical_name": "DNA repair"}
{"concept_id": "C0013057", "aliases": [], "types": ["T045"], "definition": "Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes. [GOC:ems, ISBN:0140512888, PMID:11498577]", "canonical_name": "dosage compensation"}
{"concept_id": "C0013124", "aliases": ["drinking behavior"], "types": ["T055"], "definition": "Behaviors associated with the ingesting of water and other liquids; includes rhythmic patterns of drinking (time intervals - onset and duration), frequency and satiety.", "canonical_name": "drinking behaviour"}
{"concept_id": "C0013203", "aliases": [], "types": ["T038"], "definition": "Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.", "canonical_name": "drug resistance"}
{"concept_id": "C0013470", "aliases": [], "types": ["T040"], "definition": "The consumption of edible substances.", "canonical_name": "eating"}
{"concept_id": "C0013529", "aliases": ["echolocation", "biological sonar"], "types": ["T040"], "definition": "An auditory orientation mechanism involving the emission of high frequency sounds which are reflected back to the emitter (animal).", "canonical_name": "perception of environment using reflected sound waves"}
{"concept_id": "C0013936", "aliases": ["embryo development", "embryogenesis"], "types": ["T042"], "definition": "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]", "canonical_name": "embryonal development"}
{"concept_id": "C0014139", "aliases": ["vesicle endocytosis", "endocytosis"], "types": ["T043"], "definition": "Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.", "canonical_name": "endocytic import into cell"}
{"concept_id": "C0014239", "aliases": ["ER"], "types": ["T026"], "definition": "A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)", "canonical_name": "endoplasmic reticulum"}
{"concept_id": "C0014587", "aliases": [], "types": ["T114", "T123"], "canonical_name": "episome"}
{"concept_id": "C0014819", "aliases": ["erythrocyte differentiation", "red blood cell differentiation", "erythropoiesis", "erythrocyte cell differentiation"], "types": ["T042"], "definition": "The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.", "canonical_name": "RBC differentiation"}
{"concept_id": "C0014906", "aliases": ["aestivation"], "types": ["T040"], "definition": "In certain living species, a period of dormancy during the summer months marked by decreased metabolism.", "canonical_name": "estivation"}
{"concept_id": "C0014948", "aliases": ["estrus"], "types": ["T039"], "definition": "The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.", "canonical_name": "oestrus"}
{"concept_id": "C0015283", "aliases": ["exocytosis"], "types": ["T043"], "definition": "Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.", "canonical_name": "vesicle exocytosis"}
{"concept_id": "C0015328", "aliases": ["exploration behavior", "exploration behaviour", "exploratory behaviour"], "types": ["T055"], "definition": "The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.", "canonical_name": "exploratory behavior"}
{"concept_id": "C0015350", "aliases": ["extracellular matrix"], "types": ["T024"], "definition": "A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.", "canonical_name": "proteinaceous extracellular matrix"}
{"concept_id": "C0015352", "aliases": ["intercellular space"], "types": ["T030"], "definition": "Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.", "canonical_name": "extracellular space"}
{"concept_id": "C0015745", "aliases": ["eating behaviour", "behavioural response to food", "feeding behaviour", "feeding behavior", "behavioral response to food"], "types": ["T040"], "definition": "Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals.", "canonical_name": "eating behavior"}
{"concept_id": "C0015852", "aliases": [], "types": ["T044"], "definition": "Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.", "canonical_name": "fermentation"}
{"concept_id": "C0015914", "aliases": ["fertilization"], "types": ["T040"], "definition": "The fusion of a spermatozoon (SPERMATOZOA) with an OVUM thus resulting in the formation of a ZYGOTE.", "canonical_name": "syngamy"}
{"concept_id": "C0015967", "aliases": [], "types": ["T184"], "definition": "An abnormal elevation of body temperature, usually as a result of a pathologic process.", "canonical_name": "pyrexia"}
{"concept_id": "C0016017", "aliases": [], "types": ["T039"], "definition": "The natural enzymatic dissolution of FIBRIN.", "canonical_name": "fibrinolysis"}
{"concept_id": "C0016192", "aliases": [], "types": ["T026"], "definition": "A whiplike motility appendage present on the surface cells. Prokaryote flagella are composed of a protein called FLAGELLIN. Bacteria can have a single flagellum, a tuft at one pole, or multiple flagella covering the entire surface. In eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella have the same basic structure as CILIA but are longer in proportion to the cell bearing them and present in much smaller numbers. (From King & Stansfield, A Dictionary of Genetics, 4th ed)", "canonical_name": "flagellum"}
{"concept_id": "C0016243", "aliases": ["cell-cell adhesion involved in flocculation"], "types": ["T043"], "definition": "The aggregation of suspended solids into larger clumps.", "canonical_name": "flocculation"}
{"concept_id": "C0016434", "aliases": [], "types": ["T039"], "definition": "The period of the MENSTRUAL CYCLE representing follicular growth, increase in ovarian estrogen (ESTROGENS) production, and epithelial proliferation of the ENDOMETRIUM. Follicular phase begins with the onset of MENSTRUATION and ends with OVULATION.", "canonical_name": "follicular phase"}
{"concept_id": "C0017001", "aliases": [], "types": ["T042"], "definition": "The process of germ cell development from the primordial GERM CELLS to the mature haploid GAMETES: ova in the female (OOGENESIS) or sperm in the male (SPERMATOGENESIS).", "canonical_name": "gametogenesis"}
{"concept_id": "C0017127", "aliases": [], "types": ["T042"], "definition": "The evacuation of food from the stomach into the duodenum.", "canonical_name": "gastric emptying"}
{"concept_id": "C0017259", "aliases": [], "types": ["T045"], "definition": "The asymmetrical segregation of genes during replication which leads to the production of non-reciprocal recombinant strands and the apparent conversion of one allele into another. Thus, e.g., the meiotic products of an Aa individual may be AAAa or aaaA instead of AAaa, i.e., the A allele has been converted into the a allele or vice versa.", "canonical_name": "gene conversion"}
{"concept_id": "C0017262", "aliases": [], "types": ["T045"], "definition": "The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.", "canonical_name": "gene expression"}
{"concept_id": "C0017263", "aliases": ["regulation of gene expression"], "types": ["T045"], "definition": "Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.", "canonical_name": "gene regulation"}
{"concept_id": "C0017301", "aliases": ["general adaptation syndrome, physiological response", "physiological process during general adaptation syndrome", "general adaptation syndrome, physiological process", "physiological response during general adaptation syndrome"], "types": ["T039"], "definition": "The sum of all nonspecific systemic reactions of the body to long-continued exposure to systemic stress.", "canonical_name": "general adaptation syndrome"}
{"concept_id": "C0017639", "aliases": [], "types": ["T046"], "definition": "The production of a dense fibrous network of neuroglia; includes astrocytosis, which is a proliferation of astrocytes in the area of a degenerative lesion.", "canonical_name": "gliosis"}
{"concept_id": "C0017715", "aliases": ["gluconeogenesis", "glucose biosynthetic process"], "types": ["T044"], "definition": "Biosynthesis of GLUCOSE from nonhexose or non-carbohydrate precursors, such as LACTATE; PYRUVATE; ALANINE; and GLYCEROL.", "canonical_name": "glucose biosynthesis"}
{"concept_id": "C0017952", "aliases": ["anaerobic glycolysis", "glycolysis"], "types": ["T044"], "definition": "A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.", "canonical_name": "glycolytic process"}
{"concept_id": "C0017982", "aliases": [], "types": ["T070"], "definition": "The synthetic chemistry reaction or enzymatic reaction of adding carbohydrate or glycosyl groups. GLYCOSYLTRANSFERASES carry out the enzymatic glycosylation reactions. The spontaneous, non-enzymatic attachment of reducing sugars to free amino groups in proteins, lipids, or nucleic acids is called GLYCATION (see MAILLARD REACTION).", "canonical_name": "glycosylation"}
{"concept_id": "C0018042", "aliases": ["Golgi apparatus", "Golgi", "Golgi complex location", "dictyosome"], "types": ["T026"], "definition": "A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)", "canonical_name": "Golgi complex"}
{"concept_id": "C0018270", "aliases": [], "types": ["T040"], "definition": "Gradual increase in the number, the size, and the complexity of cells of an individual. Growth generally results in increase in ORGAN WEIGHT; BODY WEIGHT; and BODY HEIGHT.", "canonical_name": "growth"}
{"concept_id": "C0018767", "aliases": ["hearing", "sensory perception of sound"], "types": ["T039"], "definition": "The ability or act of sensing and transducing ACOUSTIC STIMULATION to the CENTRAL NERVOUS SYSTEM. It is also called audition.", "canonical_name": "perception of sound"}
{"concept_id": "C0018951", "aliases": ["hematopoiesis", "haemopoiesis", "hemopoiesis", "blood cell formation"], "types": ["T042"], "definition": "The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).", "canonical_name": "blood cell biosynthesis"}
{"concept_id": "C0019116", "aliases": [], "types": ["T042"], "definition": "The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.", "canonical_name": "hemostasis"}
{"concept_id": "C0019397", "aliases": ["heterochromatin", "transcriptionally silent chromatin"], "types": ["T026"], "definition": "The portion of chromosome material that remains condensed and is transcriptionally inactive during INTERPHASE.", "canonical_name": "transcriptionally inactive chromatin"}
{"concept_id": "C0019516", "aliases": [], "types": ["T040"], "definition": "The dormant state in which some warm-blooded animal species pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs.", "canonical_name": "hibernation"}
{"concept_id": "C0019868", "aliases": ["homeostasis"], "types": ["T038"], "definition": "The processes whereby the internal environment of an organism tends to remain balanced and stable.", "canonical_name": "homeostatic process"}
{"concept_id": "C0020517", "aliases": [], "types": ["T046"], "definition": "Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.", "canonical_name": "hypersensitivity"}
{"concept_id": "C0020522", "aliases": ["delayed-type hypersensitivity", "delayed hypersensitivity response"], "types": ["T046"], "definition": "An increased reactivity to specific antigens mediated not by antibodies but by sensitized T CELLS.", "canonical_name": "type IV hypersensitivity"}
{"concept_id": "C0020523", "aliases": ["type I hypersensitivity"], "types": ["T046"], "definition": "Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.", "canonical_name": "immediate hypersensitivity response"}
{"concept_id": "C0020855", "aliases": [], "types": ["T116", "T129"], "canonical_name": "IgG1"}
{"concept_id": "C0020856", "aliases": [], "types": ["T116", "T129"], "canonical_name": "IgG2"}
{"concept_id": "C0020964", "aliases": [], "types": ["T042"], "definition": "Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.", "canonical_name": "immune response"}
{"concept_id": "C0020966", "aliases": [], "types": ["T040"], "definition": "Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.", "canonical_name": "cell-mediated immunity"}
{"concept_id": "C0020969", "aliases": ["innate immune response", "nonspecific immune response"], "types": ["T032"], "definition": "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]", "canonical_name": "innate immunity"}
{"concept_id": "C0021368", "aliases": [], "types": ["T046"], "definition": "A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.", "canonical_name": "inflammation"}
{"concept_id": "C0021575", "aliases": [], "types": ["T032"], "definition": "The development by insects of resistance to insecticides.", "canonical_name": "insecticide resistance"}
{"concept_id": "C0021586", "aliases": [], "types": ["T042"], "definition": "The deposit of SEMEN or SPERMATOZOA into the VAGINA to facilitate FERTILIZATION.", "canonical_name": "insemination"}
{"concept_id": "C0021721", "aliases": ["cell junction", "intercellular junction"], "types": ["T030"], "definition": "Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)", "canonical_name": "cell-cell junction"}
{"concept_id": "C0021770", "aliases": [], "types": ["T026"], "definition": "Cytoplasmic filaments intermediate in diameter (about 10 nanometers) between the microfilaments and the microtubules. They may be composed of any of a number of different proteins and form a ring around the cell nucleus.", "canonical_name": "intermediate filament"}
{"concept_id": "C0021798", "aliases": ["interphase"], "types": ["T043"], "definition": "The interval between two successive CELL DIVISIONS during which the CHROMOSOMES are not individually distinguishable. It is composed of the G phases (G1 PHASE; G0 PHASE; G2 PHASE) and S PHASE (when DNA replication occurs).", "canonical_name": "karyostasis"}
{"concept_id": "C0021800", "aliases": [], "types": ["T023"], "definition": "Structures in fishes homologous to the cortical tissue of the mammalian adrenal gland; they are in close proximity to or imbedded in the kidney.", "canonical_name": "interrenal gland"}
{"concept_id": "C0021826", "aliases": [], "types": ["T042"], "definition": "Uptake of substances through the lining of the INTESTINES.", "canonical_name": "intestinal absorption"}
{"concept_id": "C0021838", "aliases": [], "types": ["T042"], "definition": "Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth). [GOC:sl, PMID:15890336]", "canonical_name": "intestinal motility"}
{"concept_id": "C0021868", "aliases": [], "types": ["T026"], "definition": "Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.", "canonical_name": "intracellular membrane"}
{"concept_id": "C0022566", "aliases": [], "types": ["T042"], "definition": "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]", "canonical_name": "keratinization"}
{"concept_id": "C0022699", "aliases": [], "types": ["T055"], "definition": "Locomotor behavior not involving a steering reaction, but in which there may be a turning random in direction. It includes orthokinesis, the rate of movement and klinokinesis, the amount of turning, which are related to the intensity of stimulation.", "canonical_name": "kinesis"}
{"concept_id": "C0022701", "aliases": ["kinesthesia"], "types": ["T040"], "definition": "Sense of movement of a part of the body, such as movement of fingers, elbows, knees, limbs, or weights.", "canonical_name": "perception of rate of movement"}
{"concept_id": "C0022925", "aliases": ["lactation"], "types": ["T042"], "definition": "The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.", "canonical_name": "milk secretion"}
{"concept_id": "C0023185", "aliases": [], "types": ["T041"], "definition": "Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge.", "canonical_name": "learning"}
{"concept_id": "C0023796", "aliases": ["lipolysis", "lipid degradation", "lipid catabolic process", "lipid catabolism"], "types": ["T040"], "definition": "The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.", "canonical_name": "lipid breakdown"}
{"concept_id": "C0023907", "aliases": [], "types": ["T042"], "definition": "Repair or renewal of hepatic tissue.", "canonical_name": "liver regeneration"}
{"concept_id": "C0023946", "aliases": [], "types": ["T040"], "definition": "Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.", "canonical_name": "locomotion"}
{"concept_id": "C0024153", "aliases": [], "types": ["T039"], "definition": "The period in the MENSTRUAL CYCLE that follows OVULATION, characterized by the development of CORPUS LUTEUM, increase in PROGESTERONE production by the OVARY and secretion by the glandular epithelium of the ENDOMETRIUM. The luteal phase begins with ovulation and ends with the onset of MENSTRUATION.", "canonical_name": "luteal phase"}
{"concept_id": "C0024262", "aliases": [], "types": ["T043"], "definition": "Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.", "canonical_name": "lymphocyte activation"}
{"concept_id": "C0024369", "aliases": [], "types": ["T026"], "definition": "A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured or undergoes MEMBRANE FUSION. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed).", "canonical_name": "lysosome"}
{"concept_id": "C0024426", "aliases": ["macrophage activation"], "types": ["T043"], "definition": "The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.", "canonical_name": "macrophage polarization"}
{"concept_id": "C0024888", "aliases": ["chewing"], "types": ["T040"], "definition": "The act and process of chewing and grinding food in the mouth.", "canonical_name": "mastication"}
{"concept_id": "C0024919", "aliases": ["maternal behaviour"], "types": ["T054"], "definition": "The behavior patterns associated with or characteristic of a mother.", "canonical_name": "maternal behavior"}
{"concept_id": "C0025213", "aliases": [], "types": ["T026"], "definition": "Melanin-containing organelles found in melanocytes and melanophores.", "canonical_name": "melanosome"}
{"concept_id": "C0025246", "aliases": ["membrane fusion"], "types": ["T044"], "definition": "The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.", "canonical_name": "cellular membrane fusion"}
{"concept_id": "C0025260", "aliases": [], "types": ["T041"], "definition": "Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.", "canonical_name": "memory"}
{"concept_id": "C0025265", "aliases": [], "types": ["T041"], "definition": "Remembrance of information for a few seconds to hours.", "canonical_name": "short-term memory"}
{"concept_id": "C0025274", "aliases": [], "types": ["T040"], "definition": "The first MENSTRUAL CYCLE marked by the initiation of MENSTRUATION.", "canonical_name": "menarche"}
{"concept_id": "C0025320", "aliases": [], "types": ["T039"], "definition": "The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.", "canonical_name": "menopause"}
{"concept_id": "C0025329", "aliases": [], "types": ["T040"], "definition": "The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.", "canonical_name": "menstrual cycle"}
{"concept_id": "C0025344", "aliases": [], "types": ["T040"], "definition": "The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.", "canonical_name": "menstruation"}
{"concept_id": "C0025516", "aliases": [], "types": ["T040"], "definition": "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:dos]", "canonical_name": "detoxification"}
{"concept_id": "C0025519", "aliases": ["metabolism"], "types": ["T040"], "definition": "The chemical reactions in living organisms by which energy is provided for vital processes and activities and new material is assimilated.", "canonical_name": "metabolic process"}
{"concept_id": "C0025558", "aliases": [], "types": ["T040"], "definition": "Profound physical changes during maturation of living organisms from the immature forms to the adult forms, such as from TADPOLES to frogs; caterpillars to BUTTERFLIES.", "canonical_name": "metamorphosis"}
{"concept_id": "C0025564", "aliases": [], "types": ["T043"], "definition": "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]", "canonical_name": "mitotic metaphase"}
{"concept_id": "C0025568", "aliases": [], "types": ["T049"], "definition": "A condition in which there is a change of one adult cell type to another similar adult cell type.", "canonical_name": "metaplasia"}
{"concept_id": "C0025597", "aliases": [], "types": ["T039"], "definition": "The period following ESTRUS during which the phenomena of estrus subside in those animals in which pregnancy or pseudopregnancy does not occur.", "canonical_name": "metestrus"}
{"concept_id": "C0025723", "aliases": [], "types": ["T044"], "definition": "Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)", "canonical_name": "methylation"}
{"concept_id": "C0025954", "aliases": [], "types": ["T026"], "definition": "Electron-dense cytoplasmic particles bounded by a single membrane, such as PEROXISOMES; GLYOXYSOMES; and glycosomes.", "canonical_name": "microbody"}
{"concept_id": "C0025979", "aliases": ["actin filament", "microfilament", "striated muscle filament", "actin cytoskeleton"], "types": ["T026"], "definition": "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]", "canonical_name": "myofilament"}
{"concept_id": "C0026046", "aliases": ["microtubulus", "microtubuli"], "types": ["T026"], "definition": "Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.", "canonical_name": "microtubule"}
{"concept_id": "C0026049", "aliases": ["microvillus"], "types": ["T026"], "definition": "Minute projections of cell membranes which greatly increase the surface area of the cell.", "canonical_name": "microvilli"}
{"concept_id": "C0026132", "aliases": ["milk ejection reflex"], "types": ["T042"], "definition": "Expulsion of milk from the mammary alveolar lumen, which is surrounded by a layer of milk-secreting EPITHELIAL CELLS and a network of myoepithelial cells. Contraction of the myoepithelial cells is regulated by neuroendocrine signals.", "canonical_name": "milk ejection"}
{"concept_id": "C0026237", "aliases": ["mitochondrion"], "types": ["T026"], "definition": "Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)", "canonical_name": "mitochondria"}
{"concept_id": "C0026255", "aliases": [], "types": ["T043"], "definition": "A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.", "canonical_name": "mitosis"}
{"concept_id": "C0026258", "aliases": [], "types": ["T026"], "definition": "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]", "canonical_name": "mitotic spindle"}
{"concept_id": "C0026559", "aliases": ["anatomical structure morphogenesis", "organization of an anatomical structure", "morphogenesis", "anatomical structure structural organization", "anatomical structure organization", "anatomical structure arrangement"], "types": ["T040"], "definition": "The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.", "canonical_name": "structural organization"}
{"concept_id": "C0026608", "aliases": [], "types": ["T026"], "definition": "The specialized postsynaptic region of a muscle cell. The motor endplate is immediately across the synaptic cleft from the presynaptic axon terminal. Among its anatomical specializations are junctional folds which harbor a high density of cholinergic receptors.", "canonical_name": "motor endplate"}
{"concept_id": "C0026687", "aliases": ["mucociliary clearance", "MCC", "mucociliary transport"], "types": ["T201"], "definition": "A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.", "canonical_name": "MCT"}
{"concept_id": "C0026820", "aliases": ["muscle contraction"], "types": ["T039"], "definition": "A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.", "canonical_name": "muscle motor activity"}
{"concept_id": "C0026836", "aliases": [], "types": ["T042"], "definition": "That phase of a muscle twitch during which a muscle returns to a resting position.", "canonical_name": "relaxation of muscle"}
{"concept_id": "C0026846", "aliases": [], "types": ["T046"], "definition": "Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.", "canonical_name": "muscle atrophy"}
{"concept_id": "C0026973", "aliases": [], "types": ["T026"], "definition": "The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.", "canonical_name": "myelin sheath"}
{"concept_id": "C0027045", "aliases": ["heart contraction", "cardiac contraction"], "types": ["T042"], "definition": "Contractile activity of the MYOCARDIUM.", "canonical_name": "heart beating"}
{"concept_id": "C0027075", "aliases": [], "types": ["T026"], "definition": "The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .", "canonical_name": "myofibril"}
{"concept_id": "C0027477", "aliases": [], "types": ["T042"], "definition": "Sodium excretion by URINATION.", "canonical_name": "natriuresis"}
{"concept_id": "C0027540", "aliases": ["necrosis", "cellular necrosis", "necrotic cell death"], "types": ["T042"], "definition": "The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.", "canonical_name": "tissue death"}
{"concept_id": "C0027747", "aliases": ["axon terminus", "axon terminal", "nerve ending"], "types": ["T026"], "definition": "Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.", "canonical_name": "nerve terminal"}
{"concept_id": "C0027749", "aliases": [], "types": ["T026"], "definition": "Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.", "canonical_name": "nerve fiber"}
{"concept_id": "C0027793", "aliases": ["signal transmission across a synapse", "neurotransmission", "conduction of nerve impulse", "transmission of nerve impulse", "synaptic transmission"], "types": ["T043"], "definition": "The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.", "canonical_name": "signal transmission along a neuron"}
{"concept_id": "C0027834", "aliases": ["neurofilament"], "types": ["T026"], "definition": "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter. [ISBN:0198506732, ISBN:0716731363, ISBN:0815316194]", "canonical_name": "type IV intermediate filament"}
{"concept_id": "C0027869", "aliases": ["neuromuscular junction"], "types": ["T026"], "definition": "The synapse between a neuron and a muscle.", "canonical_name": "NMJ"}
{"concept_id": "C0028161", "aliases": [], "types": ["T040"], "definition": "The process in certain BACTERIA; FUNGI; and CYANOBACTERIA converting free atmospheric NITROGEN to biologically usable forms of nitrogen, such as AMMONIA; NITRATES; and amino compounds.", "canonical_name": "nitrogen fixation"}
{"concept_id": "C0028581", "aliases": ["nuclear matrix"], "types": ["T026"], "definition": "The residual framework structure of the CELL NUCLEUS that maintains many of the overall architectural features of the cell nucleus including the nuclear lamina with NUCLEAR PORE complex structures, residual CELL NUCLEOLI and an extensive fibrogranular structure in the nuclear interior. (Advan. Enzyme Regul. 2002; 42:39-52)", "canonical_name": "nucleoskeleton"}
{"concept_id": "C0028584", "aliases": ["nuclear membrane"], "types": ["T026"], "definition": "The membrane system of the CELL NUCLEUS that surrounds the nucleoplasm. It consists of two concentric membranes separated by the perinuclear space. The structures of the envelope where it opens to the cytoplasm are called the nuclear pores (NUCLEAR PORE).", "canonical_name": "nuclear envelope"}
{"concept_id": "C0028587", "aliases": ["nuclear pore complex location", "nucleopore", "nuclear pore complex", "NPC", "nuclear pore"], "types": ["T026"], "definition": "An opening through the NUCLEAR ENVELOPE formed by the nuclear pore complex which transports nuclear proteins or RNA into or out of the CELL NUCLEUS and which, under some conditions, acts as an ion channel.", "canonical_name": "nuclear pore membrane protein"}
{"concept_id": "C0028609", "aliases": ["NOR", "nucleolus organizer region"], "types": ["T026"], "definition": "The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA.", "canonical_name": "nucleolus organiser region"}
{"concept_id": "C0028877", "aliases": ["tooth development", "odontogeny", "odontogenesis", "odontosis"], "types": ["T042"], "definition": "The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS).", "canonical_name": "tooth morphogenesis"}
{"concept_id": "C0029047", "aliases": ["oogenesis"], "types": ["T042"], "definition": "The process of germ cell development in the female from the primordial germ cells through OOGONIA to the mature haploid ova (OVUM).", "canonical_name": "ovum development"}
{"concept_id": "C0029219", "aliases": [], "types": ["T026"], "definition": "Specific particles of membrane-bound organized living substances present in eukaryotic cells, such as the MITOCHONDRIA; the GOLGI APPARATUS; ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.", "canonical_name": "organelle"}
{"concept_id": "C0029433", "aliases": ["bone formation", "bone biosynthesis", "ossification"], "types": ["T042"], "definition": "The process of bone formation. Histogenesis of bone including ossification.", "canonical_name": "osteogenesis"}
{"concept_id": "C0029957", "aliases": ["egg-laying", "egg laying"], "types": ["T040"], "definition": "The process of laying or shedding fully developed eggs (OVA) from the female body. The term is usually used for certain INSECTS or FISHES with an organ called ovipositor where eggs are stored or deposited before expulsion from the body.", "canonical_name": "oviposition"}
{"concept_id": "C0029965", "aliases": [], "types": ["T042"], "definition": "The discharge of an OVUM from a rupturing follicle in the OVARY.", "canonical_name": "ovulation"}
{"concept_id": "C0029976", "aliases": ["embryo implantation"], "types": ["T040"], "definition": "Attachment of the blastocyst to the uterine lining. [GOC:isa_complete, http://www.medterms.com]", "canonical_name": "blastocyst implantation"}
{"concept_id": "C0030013", "aliases": ["oxidative phosphorylation"], "types": ["T044"], "definition": "Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.", "canonical_name": "respiratory-chain phosphorylation"}
{"concept_id": "C0030596", "aliases": [], "types": ["T040"], "definition": "A unisexual reproduction without the fusion of a male and a female gamete (FERTILIZATION). In parthenogenesis, an individual is formed from an unfertilized OVUM that did not complete MEIOSIS. Parthenogenesis occurs in nature and can be artificially induced.", "canonical_name": "parthenogenesis"}
{"concept_id": "C0030653", "aliases": ["paternal behaviour"], "types": ["T054"], "definition": "The behavior patterns associated with or characteristic of a father.", "canonical_name": "paternal behavior"}
{"concept_id": "C0030847", "aliases": [], "types": ["T042"], "definition": "The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.", "canonical_name": "penile erection"}
{"concept_id": "C0030892", "aliases": ["pentose phosphate shunt", "pentose phosphate pathway", "hexose monophosphate pathway", "pentose-phosphate pathway"], "types": ["T044"], "definition": "The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate). [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]", "canonical_name": "pentose-phosphate shunt"}
{"concept_id": "C0031133", "aliases": [], "types": ["T042"], "definition": "A movement, caused by sequential muscle contraction, that pushes the contents of the intestines or other tubular organs in one direction.", "canonical_name": "peristalsis"}
{"concept_id": "C0031308", "aliases": [], "types": ["T043"], "definition": "The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).", "canonical_name": "phagocytosis"}
{"concept_id": "C0031309", "aliases": [], "types": ["T026"], "definition": "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes. [GOC:mah, PMID:12388753, PMID:14733906]", "canonical_name": "phagolysosome"}
{"concept_id": "C0031310", "aliases": ["phagocytic vesicle"], "types": ["T026"], "definition": "Membrane-bound cytoplasmic vesicles formed by invagination of phagocytized material. They fuse with lysosomes to form phagolysosomes in which the hydrolytic enzymes of the lysosome digest the phagocytized material.", "canonical_name": "phagosome"}
{"concept_id": "C0031715", "aliases": [], "types": ["T044"], "definition": "The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.", "canonical_name": "phosphorylation"}
{"concept_id": "C0031751", "aliases": [], "types": ["T044"], "definition": "Chemical bond cleavage reactions resulting from absorption of radiant energy.", "canonical_name": "photolysis"}
{"concept_id": "C0031755", "aliases": ["photosynthetic phosphorylation"], "types": ["T044"], "definition": "The use of light to convert ADP to ATP without the concomitant reduction of dioxygen to water as occurs during OXIDATIVE PHOSPHORYLATION in MITOCHONDRIA.", "canonical_name": "photosynthetic ATP synthesis"}
{"concept_id": "C0031764", "aliases": [], "types": ["T070"], "definition": "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide using energy obtained from light rather than from the oxidation of chemical compounds. Photosynthesis comprises two separate processes: the light reactions and the dark reactions. In higher plants; GREEN ALGAE; and CYANOBACTERIA; NADPH and ATP formed by the light reactions drive the dark reactions which result in the fixation of carbon dioxide. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)", "canonical_name": "photosynthesis"}
{"concept_id": "C0031845", "aliases": [], "types": ["T039"], "definition": "A biologic function, activity, or process involving either specialized organ functions, individual organs, organ systems, body parts, or whole organisms.", "canonical_name": "physiological process"}
{"concept_id": "C0031911", "aliases": [], "types": ["T032"], "definition": "Coloration or discoloration of a part by a pigment.", "canonical_name": "pigmentation"}
{"concept_id": "C0031921", "aliases": ["pilus", "fimbrium", "fimbriae", "pili"], "types": ["T026"], "definition": "Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of \"pili\", which is confined to sex pili (PILI, SEX).", "canonical_name": "fimbria"}
{"concept_id": "C0031924", "aliases": ["pilomotor reflex", "horripilation", "goosebump reflex"], "types": ["T042"], "definition": "Involuntary erection or bristling of hairs.", "canonical_name": "piloerection"}
{"concept_id": "C0031945", "aliases": ["pinocytosis"], "types": ["T043"], "definition": "The engulfing of liquids by cells by a process of invagination and closure of the cell membrane to form fluid-filled vacuoles.", "canonical_name": "fluid-phase endocytosis"}
{"concept_id": "C0032058", "aliases": ["placentation", "placental development"], "types": ["T042"], "definition": "The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.", "canonical_name": "placenta development"}
{"concept_id": "C0032173", "aliases": ["platelet activation"], "types": ["T042"], "definition": "A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.", "canonical_name": "blood coagulation, platelet activation"}
{"concept_id": "C0032176", "aliases": ["blood platelet aggregation"], "types": ["T043"], "definition": "The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.", "canonical_name": "platelet aggregation"}
{"concept_id": "C0032549", "aliases": [], "types": ["T116", "T126"], "definition": "Catalyze the joining of preformed ribonucleotides or deoxyribonucleotides in phosphodiester linkage during genetic processes. EC 6.5.1.", "canonical_name": "polynucleotide ligase"}
{"concept_id": "C0032592", "aliases": ["polyribosome"], "types": ["T026"], "definition": "A multiribosomal structure representing a linear array of RIBOSOMES held together by messenger RNA; (RNA, MESSENGER); They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)", "canonical_name": "polysome"}
{"concept_id": "C0032961", "aliases": ["gestation"], "types": ["T040"], "definition": "The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.", "canonical_name": "female pregnancy"}
{"concept_id": "C0033274", "aliases": [], "types": ["T039"], "definition": "A phase of the ESTROUS CYCLE that precedes ESTRUS. During proestrus, the Graafian follicles undergo maturation.", "canonical_name": "proestrus"}
{"concept_id": "C0033461", "aliases": ["prophage excision"], "types": ["T045"], "definition": "The molecular events that lead to the excision of a viral genome from the host genome. [GOC:mlg]", "canonical_name": "provirus excision"}
{"concept_id": "C0033462", "aliases": [], "types": ["T043"], "canonical_name": "prophage induction"}
{"concept_id": "C0033464", "aliases": [], "types": ["T079"], "definition": "The first phase of cell nucleus division, in which the CHROMOSOMES become visible, the CELL NUCLEUS starts to lose its identity, the SPINDLE APPARATUS appears, and the CENTRIOLES migrate toward opposite poles.", "canonical_name": "prophase"}
{"concept_id": "C0033499", "aliases": [], "types": ["T041"], "definition": "Sensory functions that transduce stimuli received by proprioceptive receptors in joints, tendons, muscles, and the INNER EAR into neural impulses to be transmitted to the CENTRAL NERVOUS SYSTEM. Proprioception provides sense of stationary positions and movements of one's body parts, and is important in maintaining KINESTHESIA and POSTURAL BALANCE.", "canonical_name": "proprioception"}
{"concept_id": "C0033618", "aliases": ["protein binding"], "types": ["T044"], "definition": "The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.", "canonical_name": "protein amino acid binding"}
{"concept_id": "C0033627", "aliases": [], "types": ["T044"], "definition": "Disruption of the non-covalent bonds and/or disulfide bonds responsible for maintaining the three-dimensional shape and activity of the native protein.", "canonical_name": "protein denaturation"}
{"concept_id": "C0033666", "aliases": ["posttranslational modification", "protein maturation by peptide bond cleavage", "protein maturation by peptide bond hydrolysis", "post-translational protein modification", "protein processing", "post-translational modification", "PTM"], "types": ["T044"], "definition": "Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.", "canonical_name": "posttranslational protein modification"}
{"concept_id": "C0033731", "aliases": [], "types": ["T025"], "definition": "The protoplasm and plasma membrane of plant, fungal, bacterial or archaeon cells without the CELL WALL.", "canonical_name": "protoplast"}
{"concept_id": "C0033827", "aliases": ["pseudopodium", "pseudopodial protrusion"], "types": ["T026"], "definition": "A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.", "canonical_name": "pseudopod"}
{"concept_id": "C0034011", "aliases": [], "types": ["T039"], "definition": "A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.", "canonical_name": "puberty"}
{"concept_id": "C0034667", "aliases": [], "types": ["T030"], "definition": "Regularly spaced gaps in the myelin sheaths of peripheral axons. Ranvier's nodes allow saltatory conduction, that is, jumping of impulses from node to node, which is faster and more energetically favorable than continuous conduction.", "canonical_name": "node of Ranvier"}
{"concept_id": "C0034850", "aliases": [], "types": ["T026"], "definition": "Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.", "canonical_name": "endosome"}
{"concept_id": "C0034865", "aliases": [], "types": ["T045"], "definition": "Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.", "canonical_name": "DNA recombination"}
{"concept_id": "C0034963", "aliases": [], "types": ["T042"], "definition": "The physiological renewal, repair, or replacement of tissue.", "canonical_name": "regeneration"}
{"concept_id": "C0035150", "aliases": ["reproductive physiological process"], "types": ["T040"], "definition": "The total process by which organisms produce offspring. (Stedman, 25th ed)", "canonical_name": "reproduction"}
{"concept_id": "C0035152", "aliases": [], "types": ["T040"], "definition": "Reproduction without fusion of two types of cells, mostly found in ALGAE; FUNGI; and PLANTS. Asexual reproduction occurs in several ways, such as budding, fission, or splitting from \"parent\" cells. Only few groups of ANIMALS reproduce asexually or unisexually (PARTHENOGENESIS).", "canonical_name": "asexual reproduction"}
{"concept_id": "C0035154", "aliases": ["reproductive behavior in a multicellular organism", "reproductive behaviour"], "types": ["T040"], "definition": "The specific behavior of an organism that is associated with reproduction. [GOC:jl, GOC:pr]", "canonical_name": "reproductive behavior"}
{"concept_id": "C0035380", "aliases": [], "types": ["T045"], "definition": "The action of copying RNA into DNA by reverse transcriptase.", "canonical_name": "reverse transcription"}
{"concept_id": "C0035553", "aliases": [], "types": ["T026"], "definition": "Multicomponent ribonucleoprotein structures found in the CYTOPLASM of all cells, and in MITOCHONDRIA, and PLASTIDS. They function in PROTEIN BIOSYNTHESIS via GENETIC TRANSLATION.", "canonical_name": "ribosome"}
{"concept_id": "C0035684", "aliases": [], "types": ["T045"], "definition": "Post-transcriptional biological modification of messenger, transfer, or ribosomal RNAs or their precursors. It includes cleavage, methylation, thiolation, isopentenylation, pseudouridine formation, conformational changes, and association with ribosomal protein.", "canonical_name": "RNA processing"}
{"concept_id": "C0035687", "aliases": [], "types": ["T045"], "definition": "The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.", "canonical_name": "RNA splicing"}
{"concept_id": "C0036104", "aliases": ["saliva secretion"], "types": ["T042"], "definition": "The discharge of saliva from the SALIVARY GLANDS that keeps the mouth tissues moist and aids in digestion.", "canonical_name": "salivation"}
{"concept_id": "C0036208", "aliases": [], "types": ["T026"], "definition": "The excitable plasma membrane of a muscle cell. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)", "canonical_name": "sarcolemma"}
{"concept_id": "C0036225", "aliases": [], "types": ["T026"], "definition": "The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.", "canonical_name": "sarcomere"}
{"concept_id": "C0036226", "aliases": [], "types": ["T026"], "definition": "A network of tubules and sacs in the cytoplasm of SKELETAL MUSCLE FIBERS that assist with muscle contraction and relaxation by releasing and storing calcium ions.", "canonical_name": "sarcoplasmic reticulum"}
{"concept_id": "C0036658", "aliases": [], "types": ["T042"], "definition": "The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.", "canonical_name": "sensory perception"}
{"concept_id": "C0036867", "aliases": ["sex chromatin"], "types": ["T026"], "definition": "In the interphase nucleus, a condensed mass of chromatin representing an inactivated X chromosome. Each X CHROMOSOME, in excess of one, forms sex chromatin (Barr body) in the mammalian nucleus. (from King & Stansfield, A Dictionary of Genetics, 4th ed)", "canonical_name": "Barr body"}
{"concept_id": "C0036869", "aliases": [], "types": ["T026"], "definition": "The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)", "canonical_name": "sex chromosome"}
{"concept_id": "C0036874", "aliases": ["sexual differentiation"], "types": ["T040"], "definition": "The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain.", "canonical_name": "sex differentiation"}
{"concept_id": "C0037083", "aliases": ["signalling pathway", "signal transduction"], "types": ["T043"], "definition": "The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.", "canonical_name": "signaling pathway"}
{"concept_id": "C0037313", "aliases": [], "types": ["T040"], "definition": "A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.", "canonical_name": "sleep"}
{"concept_id": "C0037361", "aliases": ["sense of smell", "olfaction", "smell perception", "scent perception"], "types": ["T040"], "definition": "The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.", "canonical_name": "sensory perception of smell"}
{"concept_id": "C0037397", "aliases": ["social behavior"], "types": ["T054"], "definition": "Any behavior caused by or affecting another individual or group usually of the same species.", "canonical_name": "social behaviour"}
{"concept_id": "C0037703", "aliases": [], "types": ["T045"], "definition": "An error-prone process for repairing damaged microbial DNA. [GOC:jl, PMID:16000023]", "canonical_name": "SOS response"}
{"concept_id": "C0037841", "aliases": [], "types": ["T043"], "definition": "The structural and functional changes by which SPERMATOZOA become capable of oocyte FERTILIZATION. It normally requires exposing the sperm to the female genital tract for a period of time to bring about increased SPERM MOTILITY and the ACROSOME REACTION before fertilization in the FALLOPIAN TUBES can take place.", "canonical_name": "sperm capacitation"}
{"concept_id": "C0037844", "aliases": [], "types": ["T026"], "definition": "The anterior portion of the spermatozoon (SPERMATOZOA) that contains mainly the nucleus with highly compact CHROMATIN material.", "canonical_name": "sperm head"}
{"concept_id": "C0037848", "aliases": ["sperm movement"], "types": ["T043"], "definition": "Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.", "canonical_name": "sperm motility"}
{"concept_id": "C0037851", "aliases": ["sperm flagellum", "sperm cilium"], "types": ["T026"], "definition": "The posterior filiform portion of the spermatozoon (SPERMATOZOA) that provides sperm motility.", "canonical_name": "sperm tail"}
{"concept_id": "C0037864", "aliases": ["generation of spermatozoa"], "types": ["T043"], "definition": "The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.", "canonical_name": "spermatogenesis"}
{"concept_id": "C0038186", "aliases": [], "types": ["T040"], "definition": "An action or movement due to the application of a sudden unexpected stimulus. [GOC:dph]", "canonical_name": "startle response"}
{"concept_id": "C0039003", "aliases": [], "types": ["T056"], "definition": "An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.", "canonical_name": "swimming"}
{"concept_id": "C0039029", "aliases": ["symbiosis, encompassing mutualism through parasitism", "symbiosis", "symbiotic interaction between species", "symbiotic interaction"], "types": ["T070"], "definition": "The relationship between two different species of organisms that are interdependent; each gains benefits from the other or a relationship between different species where both of the organisms in question benefit from the presence of the other.", "canonical_name": "symbiotic interaction between organisms"}
{"concept_id": "C0039062", "aliases": ["synaptic junction"], "types": ["T030"], "definition": "Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.", "canonical_name": "synapse"}
{"concept_id": "C0039063", "aliases": [], "types": ["T026"], "definition": "Cell membranes associated with synapses. Both presynaptic and postsynaptic membranes are included along with their integral or tightly associated specializations for the release or reception of transmitters.", "canonical_name": "synaptic membrane"}
{"concept_id": "C0039065", "aliases": [], "types": ["T026"], "definition": "Membrane-bound compartments which contain transmitter molecules. Synaptic vesicles are concentrated at presynaptic terminals. They actively sequester transmitter molecules from the cytoplasm. In at least some synapses, transmitter release occurs by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents.", "canonical_name": "synaptic vesicle"}
{"concept_id": "C0039066", "aliases": ["synaptonemal complex location"], "types": ["T026"], "definition": "The three-part structure of ribbon-like proteinaceous material that serves to align and join the paired homologous CHROMOSOMES. It is formed during the ZYGOTENE STAGE of the first meiotic division. It is a prerequisite for CROSSING OVER.", "canonical_name": "synaptonemal complex"}
{"concept_id": "C0039336", "aliases": ["sense of taste", "taste perception", "gustation", "sensory perception of taste"], "types": ["T042"], "definition": "The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.", "canonical_name": "taste"}
{"concept_id": "C0039465", "aliases": [], "types": ["T079"], "definition": "The final phase of cell nucleus division following ANAPHASE, in which two daughter nuclei are formed, the CYTOPLASM completes division, and the CHROMOSOMES lose their distinctness and are transformed into CHROMATIN threads.", "canonical_name": "telophase"}
{"concept_id": "C0039478", "aliases": ["thermoception"], "types": ["T040"], "definition": "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature). [GOC:ai, Wikipedia:Thermoception]", "canonical_name": "thermoreception"}
{"concept_id": "C0040432", "aliases": ["tooth calcification"], "types": ["T042"], "definition": "The process whereby calcium salts are deposited in the dental enamel. The process is normal in the development of bones and teeth. (Boucher's Clinical Dental Terminology, 4th ed, p43)", "canonical_name": "tooth mineralization"}
{"concept_id": "C0040624", "aliases": [], "types": ["T045"], "definition": "Increased rate of gene expression directed by TRANS-ACTIVATORS.", "canonical_name": "transactivation"}
{"concept_id": "C0040649", "aliases": [], "types": ["T045"], "definition": "The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.", "canonical_name": "transcription"}
{"concept_id": "C0042034", "aliases": ["urine voiding", "micturition"], "types": ["T040"], "definition": "Discharge of URINE, liquid waste processed by the KIDNEY, from the body.", "canonical_name": "urination"}
{"concept_id": "C0042130", "aliases": ["myometrial smooth muscle contraction", "uterine smooth muscle contraction", "myometrium contraction"], "types": ["T042"], "definition": "Contraction of the UTERINE MUSCLE.", "canonical_name": "myometrial contraction"}
{"concept_id": "C0042219", "aliases": [], "types": ["T026"], "definition": "Any spaces or cavities within a cell. They may function in digestion, storage, secretion, or excretion.", "canonical_name": "vacuole"}
{"concept_id": "C0042396", "aliases": ["negative regulation of blood vessel size"], "types": ["T042"], "definition": "The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.", "canonical_name": "vasoconstriction"}
{"concept_id": "C0042401", "aliases": ["positive regulation of blood vessel size", "vasodilation"], "types": ["T042"], "definition": "The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.", "canonical_name": "vasodilatation"}
{"concept_id": "C0042760", "aliases": [], "types": ["T026"], "definition": "The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.", "canonical_name": "virion"}
{"concept_id": "C0042765", "aliases": [], "types": ["T038"], "definition": "The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.", "canonical_name": "virulence"}
{"concept_id": "C0042767", "aliases": [], "types": ["T038"], "definition": "The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.", "canonical_name": "release from viral latency"}
{"concept_id": "C0042769", "aliases": [], "types": ["T047"], "definition": "A general term for diseases caused by viruses.", "canonical_name": "viral infection"}
{"concept_id": "C0042774", "aliases": [], "types": ["T043"], "definition": "The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.", "canonical_name": "viral replication"}
{"concept_id": "C0042789", "aliases": ["visual perception", "vision", "sensory visual perception"], "types": ["T040"], "definition": "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai]", "canonical_name": "sense of sight"}
{"concept_id": "C0042894", "aliases": [], "types": ["T018"], "definition": "The plasma membrane of the egg.", "canonical_name": "vitelline membrane"}
{"concept_id": "C0042895", "aliases": ["yolk production", "vitellogenesis"], "types": ["T042"], "definition": "The active production and accumulation of VITELLINS (egg yolk proteins) in the non-mammalian OOCYTES from circulating precursors, VITELLOGENINS. Vitellogenesis usually begins after the first MEIOSIS and is regulated by estrogenic hormones.", "canonical_name": "yolk formation"}
{"concept_id": "C0043240", "aliases": [], "types": ["T040"], "definition": "Restoration of integrity to traumatized tissue.", "canonical_name": "wound healing"}
{"concept_id": "C0043292", "aliases": [], "types": ["T026"], "definition": "The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.", "canonical_name": "X chromosome"}
{"concept_id": "C0043297", "aliases": ["dosage compensation by inactivation of X chromosome"], "types": ["T045"], "definition": "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex. [GOC:jl, GOC:mr, GOC:pr, ISBN:0140512888, PMID:11498577, PMID:20622855, Wikipedia:XY_sex-determination_system]", "canonical_name": "X chromosome inactivation"}
{"concept_id": "C0043381", "aliases": [], "types": ["T026"], "definition": "The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.", "canonical_name": "Y chromosome"}
{"concept_id": "C0043519", "aliases": [], "types": ["T026"], "definition": "A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.", "canonical_name": "zona pellucida"}
{"concept_id": "C0061622", "aliases": [], "types": ["T026"], "definition": "The carbohydrate-rich zone on the cell surface. This zone can be visualized by a variety of stains as well as by its affinity for lectins. Although most of the carbohydrate is attached to intrinsic plasma membrane molecules, the glycocalyx usually also contains both glycoproteins and proteoglycans that have been secreted into the extracellular space and then adsorbed onto the cell surface. (Alberts et al., Molecular Biology of the Cell, 3d ed, p502)", "canonical_name": "glycocalyx"}
{"concept_id": "C0079394", "aliases": [], "types": ["T045"], "definition": "A quiescent state of cells during G1 PHASE.", "canonical_name": "G0 phase"}
{"concept_id": "C0079395", "aliases": [], "types": ["T043"], "definition": "The period of the CELL CYCLE preceding DNA REPLICATION in S PHASE. Subphases of G1 include \"competence\" (to respond to growth factors), G1a (entry into G1), G1b (progression), and G1c (assembly). Progression through the G1 subphases is effected by limiting growth factors, nutrients, or inhibitors.", "canonical_name": "G1 phase"}
{"concept_id": "C0079396", "aliases": ["G2 phase of mitotic cell cycle", "mitotic G2 phase"], "types": ["T043"], "definition": "The period of the CELL CYCLE following DNA synthesis (S PHASE) and preceding M PHASE (cell division phase). The CHROMOSOMES are tetraploid in this point.", "canonical_name": "G2 phase"}
{"concept_id": "C0080129", "aliases": ["S phase"], "types": ["T079"], "definition": "Phase of the CELL CYCLE following G1 and preceding G2 when the entire DNA content of the nucleus is replicated. It is achieved by bidirectional replication at multiple sites along each chromosome.", "canonical_name": "S-phase"}
{"concept_id": "C0085103", "aliases": ["neuron protrusion", "neuron projection", "neurite", "neuron process"], "types": ["T026"], "definition": "In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. \"Neurite\" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.", "canonical_name": "neuronal cell projection"}
{"concept_id": "C0085187", "aliases": [], "types": ["T026"], "definition": "A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs.", "canonical_name": "telomere"}
{"concept_id": "C0085200", "aliases": [], "types": ["T026"], "definition": "Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.", "canonical_name": "Lewy body"}
{"concept_id": "C0085268", "aliases": ["bone remodeling"], "types": ["T042"], "definition": "The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.", "canonical_name": "bone remodelling"}
{"concept_id": "C0085304", "aliases": [], "types": ["T082"], "definition": "Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.", "canonical_name": "cell polarity"}
{"concept_id": "C0085416", "aliases": ["respiratory burst after phagocytosis", "metabolic burst after phagocytosis", "respiratory burst", "metabolic burst", "oxidative burst after phagocytosis"], "types": ["T043"], "definition": "A large increase in oxygen uptake by neutrophils and most types of tissue macrophages through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen to a superoxide. Individuals with an inherited defect in which the oxidase that reduces oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often die as a result of recurrent bacterial infections.", "canonical_name": "oxidative burst"}
{"concept_id": "C0085872", "aliases": ["basement lamina"], "types": ["T024"], "definition": "A layer of extracellular matrix found beneath epithelial tissues. It is secreted by epithelial cells and comprised of proteoglycans, laminin and type IV collagen.", "canonical_name": "basal lamina"}
{"concept_id": "C0086474", "aliases": ["prophage integration", "establishment of integrated proviral latency"], "types": ["T038"], "definition": "A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage. [GOC:jl]", "canonical_name": "provirus integration"}
{"concept_id": "C0086934", "aliases": [], "types": ["T045"], "definition": "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced. [GOC:krc, ISBN:0198506732]", "canonical_name": "mRNA splicing"}
{"concept_id": "C0108413", "aliases": [], "types": ["T116", "T126"], "canonical_name": "carbon monoxide dehydrogenase"}
{"concept_id": "C0136979", "aliases": [], "types": ["T026"], "definition": "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II. [GOC:jl, PMID:11734882, Wikipedia:Phycobilisome]", "canonical_name": "phycobilisome"}
{"concept_id": "C0149784", "aliases": [], "types": ["T039"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mah]", "canonical_name": "response to stress"}
{"concept_id": "C0162404", "aliases": [], "types": ["T038"], "definition": "The production of light by certain enzyme-catalyzed reactions in cells. [ISBN:0198506732]", "canonical_name": "bioluminescence"}
{"concept_id": "C0162584", "aliases": [], "types": ["T043"], "definition": "OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion. [ISBN:0198506732]", "canonical_name": "uniport"}
{"concept_id": "C0162585", "aliases": [], "types": ["T043"], "definition": "The movement of ions across energy-transducing cell membranes. Transport can be active, passive or facilitated. Ions may travel by themselves (uniport), or as a group of two or more ions in the same (symport) or opposite (antiport) directions.", "canonical_name": "ion transport"}
{"concept_id": "C0162638", "aliases": ["type I programmed cell death", "apoptotic process", "programmed cell death", "apoptotic programmed cell death", "apoptotic cell death", "programmed cell death by apoptosis", "PCD", "RCD"], "types": ["T043"], "definition": "A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.", "canonical_name": "apoptosis"}
{"concept_id": "C0162760", "aliases": ["protein farnesylation", "C-terminal protein farnesylation"], "types": ["T044"], "definition": "The covalent attachment of a farnesyl group to a protein. [GOC:jl]", "canonical_name": "protein amino acid farnesylation"}
{"concept_id": "C0162761", "aliases": ["protein amino acid geranylgeranylation", "C-terminal protein geranylgeranylation"], "types": ["T044"], "definition": "The covalent attachment of a geranylgeranyl group to a protein. [GOC:jl]", "canonical_name": "protein geranylgeranylation"}
{"concept_id": "C0162765", "aliases": [], "types": ["T043"], "definition": "The covalent addition of prenyl and multiprenyl residues to a macromolecule.", "canonical_name": "prenylation"}
{"concept_id": "C0162766", "aliases": ["protein prenylation", "C-terminal protein prenylation"], "types": ["T044"], "definition": "The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added. [GOC:di, ISBN:0198506732]", "canonical_name": "protein amino acid prenylation"}
{"concept_id": "C0162771", "aliases": ["spliceosome complex", "spliceosomal complex location", "spliceosome", "spliceosome complex location"], "types": ["T026"], "definition": "Organelles in which the splicing and excision reactions that remove introns from precursor messenger RNA molecules occur. One component of a spliceosome is five small nuclear RNA molecules (U1, U2, U4, U5, U6) that, working in conjunction with proteins, help to fold pieces of RNA into the right shapes and later splice them into the message.", "canonical_name": "spliceosomal complex"}
{"concept_id": "C0162782", "aliases": [], "types": ["T045"], "definition": "A process that changes the nucleotide sequence of mRNA from that of the DNA template encoding it. Some major classes of RNA editing are as follows: 1, the conversion of cytosine to uracil in mRNA; 2, the addition of variable number of guanines at pre-determined sites; and 3, the addition and deletion of uracils, templated by guide-RNAs (RNA, GUIDE, KINETOPLASTIDA).", "canonical_name": "RNA editing"}
{"concept_id": "C0162847", "aliases": [], "types": ["T044"], "definition": "Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.", "canonical_name": "protein folding"}
{"concept_id": "C0175996", "aliases": ["intracellular anatomical structure", "protoplasm", "internal to cell"], "types": ["T026"], "definition": "The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts.", "canonical_name": "intracellular"}
{"concept_id": "C0178523", "aliases": [], "types": ["T026"], "canonical_name": "brush border membrane", "definition": "The portion of the plasma membrane surrounding the brush border. [GOC:mah]"}
{"concept_id": "C0178666", "aliases": [], "types": ["T043"], "definition": "movement of glucose through a biological system; can be across cell membranes and epithelial layers and also can occur within intracellular compartments and extracellular compartments.", "canonical_name": "glucose transport"}
{"concept_id": "C0178679", "aliases": ["tissue development"], "types": ["T042"], "definition": "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. [ISBN:0471245208]", "canonical_name": "histogenesis"}
{"concept_id": "C0205386", "aliases": [], "types": ["T080"], "definition": "To travel downward.", "canonical_name": "DesCEND"}
{"concept_id": "C0205708", "aliases": [], "types": ["T026"], "definition": "A stainable aggregation of protein, lipid or small molecules in the cytoplasm.", "canonical_name": "cytoplasmic inclusion"}
{"concept_id": "C0205715", "aliases": [], "types": ["T026"], "definition": "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis. [ISBN:0140514031]", "canonical_name": "granum"}
{"concept_id": "C0206071", "aliases": ["class switch recombination", "isotype switch recombination", "isotype switching"], "types": ["T045"], "definition": "Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.", "canonical_name": "class switching"}
{"concept_id": "C0206117", "aliases": ["gap junction", "communicating junction", "zonula communicans", "gap junction macula", "macula communicans"], "types": ["T030"], "definition": "Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.", "canonical_name": "gap junction plaque"}
{"concept_id": "C0206181", "aliases": ["terminal button", "synaptic bouton", "terminal bouton", "presynaptic bouton"], "types": ["T026"], "definition": "The distal terminations of axons which are specialized for the release of neurotransmitters. Also included are varicosities along the course of axons which have similar specializations and also release transmitters. Presynaptic terminals in both the central and peripheral nervous systems are included.", "canonical_name": "bouton"}
{"concept_id": "C0206249", "aliases": ["LTP", "long-term synaptic potentiation"], "types": ["T042"], "definition": "A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.", "canonical_name": "long-term potentiation"}
{"concept_id": "C0206431", "aliases": ["antigen processing", "antigen presentation"], "types": ["T043"], "definition": "The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)", "canonical_name": "antigen processing and presentation"}
{"concept_id": "C0206523", "aliases": [], "types": ["T026"], "definition": "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments. [ISBN:0471245208]", "canonical_name": "chromoplast"}
{"concept_id": "C0206524", "aliases": [], "types": ["T026"], "definition": "Self-replicating cytoplasmic organelles of plant and algal cells that contain pigments and may synthesize and accumulate various substances. PLASTID GENOMES are used in phylogenetic studies.", "canonical_name": "plastid"}
{"concept_id": "C0220781", "aliases": ["biosynthetic process", "synthesis", "anabolism", "biosynthesis"], "types": ["T038"], "definition": "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. [GOC:curators, ISBN:0198547684]", "canonical_name": "formation"}
{"concept_id": "C0221102", "aliases": [], "types": ["T039"], "definition": "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. [ISBN:0192801023]", "canonical_name": "excretion"}
{"concept_id": "C0221145", "aliases": [], "types": ["T043"], "definition": "The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The humoral factor with thrombopoiesis-stimulating activity is designated THROMBOPOIETIN.", "canonical_name": "thrombocyte differentiation"}
{"concept_id": "C0221711", "aliases": [], "types": ["T055"], "definition": "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented. [ISBN:0582227089]", "canonical_name": "habituation"}
{"concept_id": "C0228079", "aliases": [], "types": ["T026"], "definition": "Portion of the neuronal cell soma from which the axon originates. [GOC:nln]", "canonical_name": "axon hillock"}
{"concept_id": "C0229546", "aliases": ["Herring body"], "types": ["T023"], "definition": "The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively. [ISBN:0199652473, Wikipedia:Herring_bodies]", "canonical_name": "neurosecretory body"}
{"concept_id": "C0230532", "aliases": [], "types": ["T026"], "definition": "The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division. [GOC:mah]", "canonical_name": "metaphase plate"}
{"concept_id": "C0230540", "aliases": ["nuclear intermembrane space", "perinuclear space"], "types": ["T026"], "definition": "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide. [GOC:ai]", "canonical_name": "nuclear envelope lumen"}
{"concept_id": "C0230547", "aliases": ["ICG"], "types": ["T026"], "definition": "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs). [GOC:bf, PMID:10984439]", "canonical_name": "interchromatin granule"}
{"concept_id": "C0230595", "aliases": [], "types": ["T026"], "definition": "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]", "canonical_name": "nuclear body"}
{"concept_id": "C0230609", "aliases": ["connexon complex location", "connexon", "connexin complex", "connexon complex"], "types": ["T026"], "definition": "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. [PMID:11146276]", "canonical_name": "connexin complex location"}
{"concept_id": "C0230613", "aliases": ["belt desmosome", "zonula adherens", "adhesion belt", "zonula adhaerens"], "types": ["T026"], "definition": "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. [ISBN:0815316208]", "canonical_name": "intermediate junction"}
{"concept_id": "C0230616", "aliases": [], "types": ["T026"], "definition": "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces. [GOC:kmv, ISBN:0815316208, PMID:20205195]", "canonical_name": "hemidesmosome"}
{"concept_id": "C0230624", "aliases": [], "types": ["T026"], "definition": "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods. [ISBN:0815332181, PMID:11700298, PMID:12612641, PMID:20795303, PMID:28636800]", "canonical_name": "septate junction"}
{"concept_id": "C0230625", "aliases": [], "types": ["T026"], "canonical_name": "cell process"}
{"concept_id": "C0230626", "aliases": [], "types": ["T026"], "definition": "An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles. [GOC:ecd, PMID:15661519, PMID:7840137]", "canonical_name": "stereocilium"}
{"concept_id": "C0230628", "aliases": [], "types": ["T026"], "definition": "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194]", "canonical_name": "lamellipodium"}
{"concept_id": "C0230629", "aliases": ["uropod"], "types": ["T026"], "definition": "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively. [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750]", "canonical_name": "uropodium"}
{"concept_id": "C0230636", "aliases": [], "types": ["T026"], "canonical_name": "secondary podocyte projection"}
{"concept_id": "C0230646", "aliases": ["canalicular membrane"], "types": ["T026"], "definition": "An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates. [GOC:mah, ISBN:0721662544, PMID:10700045]", "canonical_name": "intracellular canaliculus"}
{"concept_id": "C0230647", "aliases": [], "types": ["T026"], "definition": "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates. [ISBN:0721662544]", "canonical_name": "intercellular canaliculus"}
{"concept_id": "C0230653", "aliases": ["caveola"], "types": ["T026"], "definition": "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198]", "canonical_name": "caveolae"}
{"concept_id": "C0230681", "aliases": [], "types": ["T026"], "definition": "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. [GOC:jl, ISBN:0198506732]", "canonical_name": "zymogen granule"}
{"concept_id": "C0230698", "aliases": ["membrane-coating granule", "keratinosome", "lamellar body"], "types": ["T026"], "definition": "A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. [GOC:cjm, GOC:jl, PMID:12243725, Wikipedia:Lamellar_granule]", "canonical_name": "lamellar granule"}
{"concept_id": "C0230704", "aliases": ["adiposome", "lipid particle", "lipid droplet"], "types": ["T026"], "definition": "Dynamic cytoplasmic organelles found in almost all cells. They consist of a central core of LIPIDS surrounded by a phospholipid monolayer studded with surface proteins, and are involved in LIPID METABOLISM and storage.", "canonical_name": "lipid body"}
{"concept_id": "C0230715", "aliases": ["Q disc", "transverse disc", "A band", "anisotropic disc"], "types": ["T026"], "definition": "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. [ISBN:0321204131]", "canonical_name": "A disc"}
{"concept_id": "C0230716", "aliases": ["J disc", "I disc", "I band"], "types": ["T026"], "definition": "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. [ISBN:0321204131]", "canonical_name": "isotropic disc"}
{"concept_id": "C0230717", "aliases": ["H band", "H zone"], "types": ["T026"], "definition": "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments. [GOC:mtg_muscle, ISBN:0321204131]", "canonical_name": "H disc"}
{"concept_id": "C0230718", "aliases": ["mesophragma", "M band", "M line"], "types": ["T026"], "definition": "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]", "canonical_name": "M disc"}
{"concept_id": "C0230719", "aliases": ["Z disc", "Z band", "Z line"], "types": ["T026"], "definition": "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194]", "canonical_name": "Z disk"}
{"concept_id": "C0230739", "aliases": [], "types": ["T026"], "definition": "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:clt]", "canonical_name": "spindle pole"}
{"concept_id": "C0230742", "aliases": [], "types": ["T026"], "definition": "An immature form of a centriole or basal body.", "canonical_name": "procentriole"}
{"concept_id": "C0230743", "aliases": [], "types": ["T026"], "definition": "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. [GOC:BHF, PMID:10579718, PMID:12403812]", "canonical_name": "centriolar satellite"}
{"concept_id": "C0230744", "aliases": [], "types": ["T026"], "definition": "The basal bodies of CILIA.", "canonical_name": "blepharoplast"}
{"concept_id": "C0230750", "aliases": [], "types": ["T026"], "definition": "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. [GOC:bf, GOC:cilia, ISBN:0198547684]", "canonical_name": "axoneme"}
{"concept_id": "C0230764", "aliases": [], "types": ["T026"], "definition": "The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]", "canonical_name": "Golgi membrane"}
{"concept_id": "C0230765", "aliases": ["Golgi cisterna", "Golgi cisternae"], "types": ["T026"], "definition": "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. [GOC:mah]", "canonical_name": "Golgi stack"}
{"concept_id": "C0230767", "aliases": [], "types": ["T026"], "canonical_name": "Golgi vesicle"}
{"concept_id": "C0230770", "aliases": ["endoplasmic reticulum membrane"], "types": ["T026"], "definition": "The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]", "canonical_name": "ER membrane"}
{"concept_id": "C0230779", "aliases": ["rough ER", "rough endoplasmic reticulum"], "types": ["T026"], "definition": "A type of endoplasmic reticulum (ER) where polyribosomes are present on the cytoplasmic surfaces of the ER membranes. This form of ER is prominent in cells specialized for protein secretion and its principal function is to segregate proteins destined for export or intracellular utilization.", "canonical_name": "RER"}
{"concept_id": "C0230789", "aliases": ["SER", "smooth ER"], "types": ["T026"], "definition": "A type of endoplasmic reticulum lacking associated ribosomes on the membrane surface. It exhibits a wide range of specialized metabolic functions including supplying enzymes for steroid synthesis, detoxification, and glycogen breakdown. In muscle cells, smooth endoplasmic reticulum is called SARCOPLASMIC RETICULUM.", "canonical_name": "smooth endoplasmic reticulum"}
{"concept_id": "C0230790", "aliases": ["smooth endoplasmic reticulum membrane", "SER membrane"], "types": ["T026"], "definition": "The lipid bilayer surrounding the smooth endoplasmic reticulum. [GOC:mah]", "canonical_name": "smooth ER membrane"}
{"concept_id": "C0230801", "aliases": [], "types": ["T026"], "definition": "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER. [PMID:12631728]", "canonical_name": "annulate lamellae"}
{"concept_id": "C0230812", "aliases": ["lysosome membrane"], "types": ["T026"], "definition": "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]", "canonical_name": "lysosomal membrane"}
{"concept_id": "C0230814", "aliases": [], "types": ["T026"], "definition": "A lysosome before it has fused with a vesicle or vacuole. [GOC:jl, ISBN:0815316194]", "canonical_name": "primary lysosome"}
{"concept_id": "C0230815", "aliases": [], "types": ["T026"], "definition": "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome. [GOC:jl, ISBN:0815316194]", "canonical_name": "secondary lysosome"}
{"concept_id": "C0230822", "aliases": ["degrading autophagic vacuole", "autolysosome", "autophagolysosome"], "types": ["T026"], "definition": "A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases. [GOC:sart, NIF_Subcellular:sao8444068431, PMID:19008921]", "canonical_name": "AVd"}
{"concept_id": "C0230825", "aliases": ["MVB", "multivesicular body", "MVE"], "types": ["T026"], "definition": "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. [PMID:11566881, PMID:16533950]", "canonical_name": "multivesicular endosome"}
{"concept_id": "C0230827", "aliases": [], "types": ["T026"], "definition": "A membrane-bounded vesicle wholly contained within a multivesicular body. [GOC:pde, PMID:21183070]", "canonical_name": "multivesicular body, internal vesicle"}
{"concept_id": "C0230832", "aliases": [], "types": ["T026"], "definition": "The lipid bilayer surrounding a microbody. [GOC:mah]", "canonical_name": "microbody membrane"}
{"concept_id": "C0230839", "aliases": ["mitochondrion outer membrane", "outer mitochondrion membrane", "mitochondrial outer membrane"], "types": ["T026"], "definition": "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai]", "canonical_name": "outer mitochondrial membrane"}
{"concept_id": "C0230840", "aliases": ["mitochondrial inner membrane", "inner mitochondrial membrane", "inner mitochondrion membrane"], "types": ["T026"], "definition": "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]", "canonical_name": "mitochondrion inner membrane"}
{"concept_id": "C0230844", "aliases": ["mitochondrial cristae", "cristae"], "types": ["T026"], "definition": "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria. [ISBN:0198506732]", "canonical_name": "mitochondrial crista"}
{"concept_id": "C0230871", "aliases": ["mitochondrial division"], "types": ["T043"], "definition": "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [PMID:11038192]", "canonical_name": "mitochondrial fission"}
{"concept_id": "C0230872", "aliases": [], "types": ["T026"], "definition": "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum. [GOC:mb]", "canonical_name": "kinetoplast"}
{"concept_id": "C0230899", "aliases": ["elastic fibre", "elastic fiber"], "types": ["T024"], "definition": "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. [GOC:BHF, GOC:mah, PMID:20236620]", "canonical_name": "elastin fiber"}
{"concept_id": "C0230936", "aliases": [], "types": ["T026"], "definition": "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins. [PMID:31921091, PMID:33327493]", "canonical_name": "mesosome"}
{"concept_id": "C0231256", "aliases": [], "types": ["T040"], "canonical_name": "body growth"}
{"concept_id": "C0231564", "aliases": [], "types": ["T042"], "definition": "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. [ISBN:0878932437]", "canonical_name": "intramembranous ossification"}
{"concept_id": "C0232217", "aliases": [], "types": ["T042"], "definition": "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. [GOC:dph]", "canonical_name": "cardiac conduction"}
{"concept_id": "C0232407", "aliases": [], "types": ["T042"], "canonical_name": "hair growth"}
{"concept_id": "C0232552", "aliases": ["gastric acid secretion"], "types": ["T042"], "definition": "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. [GOC:hjd]", "canonical_name": "hydrochloric acid secretion"}
{"concept_id": "C0232572", "aliases": [], "types": ["T042"], "definition": "The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum. [GOC:cy, ISBN:9781416032458, PMID:16139031]", "canonical_name": "gastric motility"}
{"concept_id": "C0232585", "aliases": ["regulation of small intestine emptying", "regulation of gastric emptying"], "types": ["T042"], "definition": "Any process that modulates the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum. [GOC:sl, PMID:15890336]", "canonical_name": "regulation of small bowel emptying"}
{"concept_id": "C0232604", "aliases": ["digestive rumination"], "types": ["T038"], "definition": "A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again. [GOC:maf, Wikipedia:Rumination]", "canonical_name": "rumination"}
{"concept_id": "C0232757", "aliases": [], "types": ["T042"], "definition": "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. [GOC:ecd]", "canonical_name": "bile acid secretion"}
{"concept_id": "C0232809", "aliases": [], "types": ["T042"], "definition": "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein. [GOC:mtg_cardio, GOC:sart, ISBN:0721643949]", "canonical_name": "glomerular filtration"}
{"concept_id": "C0232976", "aliases": ["spermatid development", "spermatid cell development"], "types": ["T043"], "definition": "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. [GOC:dph, GOC:go_curators]", "canonical_name": "spermiogenesis"}
{"concept_id": "C0234097", "aliases": ["cholinergic synaptic transmission"], "types": ["T042"], "definition": "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, Wikipedia:Cholinergic]", "canonical_name": "synaptic transmission, cholinergic"}
{"concept_id": "C0234101", "aliases": ["synaptic transmission, dopaminergic"], "types": ["T042"], "definition": "The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, GOC:dph]", "canonical_name": "dopaminergic synaptic transmission"}
{"concept_id": "C0234156", "aliases": ["righting response"], "types": ["T042"], "definition": "A reflex process in which an animal immediately tries to turn over after being placed in a supine position. [GOC:dph, PMID:8635460]", "canonical_name": "righting reflex"}
{"concept_id": "C0234194", "aliases": [], "types": ["T042"], "definition": "Sensing of noxious mechanical, thermal or chemical stimuli by NOCICEPTORS. It is the sensory component of visceral and tissue pain (NOCICEPTIVE PAIN).", "canonical_name": "nociception"}
{"concept_id": "C0234557", "aliases": ["CSF flow", "CSF circulation", "cerebrospinal fluid flow"], "types": ["T042"], "definition": "The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional. [GOC:mgi_curators, PMID:22100360, PMID:24229449]", "canonical_name": "cerebrospinal fluid circulation"}
{"concept_id": "C0234682", "aliases": ["light absorption"], "types": ["T043"], "definition": "The reception of a photon by a cell. [GOC:go_curators]", "canonical_name": "absorption of light"}
{"concept_id": "C0236033", "aliases": [], "types": ["T042"], "definition": "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. [GOC:mtg_muscle]", "canonical_name": "muscle hypertrophy"}
{"concept_id": "C0242290", "aliases": ["organogenesis", "animal organ development"], "types": ["T038"], "definition": "Formation of differentiated cells and complicated tissue organization to provide specialized functions.", "canonical_name": "development of an organ"}
{"concept_id": "C0242358", "aliases": ["tight junction", "zonula occludens", "occluding junction", "occluding cell junction"], "types": ["T030"], "definition": "Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)", "canonical_name": "bicellular tight junction"}
{"concept_id": "C0242599", "aliases": [], "types": ["T039"], "definition": "The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.", "canonical_name": "neutrophil activation"}
{"concept_id": "C0242607", "aliases": ["MTOC", "microtubule organising centre"], "types": ["T026"], "definition": "An amorphous region of electron dense material in the cytoplasm from which the MICROTUBULES polymerization is nucleated. The pericentriolar region of the CENTROSOME which surrounds the CENTRIOLES is an example.", "canonical_name": "microtubule organizing center"}
{"concept_id": "C0242608", "aliases": [], "types": ["T026"], "definition": "The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).", "canonical_name": "centrosome"}
{"concept_id": "C0242731", "aliases": ["geotropism"], "types": ["T039"], "definition": "The directional growth of organisms in response to gravity. In plants, the main root is positively gravitropic (growing downwards) and a main stem is negatively gravitropic (growing upwards), irrespective of the positions in which they are placed. Plant gravitropism is thought to be controlled by auxin (AUXINS), a plant growth substance. (From Concise Dictionary of Biology, 1990)", "canonical_name": "gravitropism"}
{"concept_id": "C0242732", "aliases": [], "types": ["T039"], "definition": "The directional growth of an organism in response to an external stimulus such as light, touch, or gravity. Growth towards the stimulus is a positive tropism; growth away from the stimulus is a negative tropism. (From Concise Dictionary of Biology, 1990)", "canonical_name": "tropism"}
{"concept_id": "C0242734", "aliases": [], "types": ["T039"], "definition": "The directional growth of organisms in response to light. In plants, aerial shoots usually grow towards light. The phototropic response is thought to be controlled by auxin (= AUXINS), a plant growth substance. (From Concise Dictionary of Biology, 1990)", "canonical_name": "phototropism"}
{"concept_id": "C0242915", "aliases": [], "types": ["T026"], "definition": "Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS.", "canonical_name": "coated vesicle"}
{"concept_id": "C0243102", "aliases": ["enzyme activity"], "types": ["T044"], "definition": "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. [GOC:vw, ISBN:0198506732]", "canonical_name": "catalytic activity"}
{"concept_id": "C0259902", "aliases": [], "types": ["T040"], "definition": "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. [GOC:curators, ISBN:9780878933846]", "canonical_name": "gastrulation"}
{"concept_id": "C0260000", "aliases": ["secondary metabolite metabolic process", "secondary metabolite metabolism", "secondary metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. [GOC:go_curators]", "canonical_name": "secondary metabolism"}
{"concept_id": "C0260080", "aliases": [], "types": ["T026"], "definition": "Microbodies which occur in plant cells, and in some eukaryotic microorganisms, and which contain enzymes of the glyoxylate cycle. (Singleton and Stainsbury, Dictionary of Microbiology and Molecular Biology, 2nd ed)", "canonical_name": "glyoxysome"}
{"concept_id": "C0277921", "aliases": [], "types": ["T043"], "definition": "The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]", "canonical_name": "diapedesis"}
{"concept_id": "C0282498", "aliases": [], "types": ["T039"], "definition": "A sequence of responses that occur when an organism is exposed to excessive heat. In humans, an increase in skin temperature triggers muscle relaxation, sweating, and vasodilation.", "canonical_name": "response to heat shock"}
{"concept_id": "C0282557", "aliases": [], "types": ["T042"], "definition": "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract. [GO_REF:0000022, GOC:jal, ISBN:0781735149]", "canonical_name": "mucosal immune response"}
{"concept_id": "C0282572", "aliases": [], "types": ["T045"], "definition": "A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES); RETROTRANSPOSONS; and bacterial insertion elements but also in some cellular genes.", "canonical_name": "translational frameshifting"}
{"concept_id": "C0282629", "aliases": ["virion organization", "virion assembly and maintenance", "viral particle assembly", "virus particle assembly", "virion assembly", "viral assembly"], "types": ["T038"], "definition": "The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.", "canonical_name": "virus assembly"}
{"concept_id": "C0282636", "aliases": ["oxidative metabolism", "cellular respiration", "oxidative metabolic process", "aerobic respiration"], "types": ["T043"], "definition": "The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.", "canonical_name": "respiration"}
{"concept_id": "C0302125", "aliases": [], "types": ["T043"], "definition": "The movement of a mast cell within or between different tissues and organs of the body. [GOC:cvs, PMID:24152847]", "canonical_name": "mast cell migration"}
{"concept_id": "C0302600", "aliases": ["angiogenesis"], "types": ["T042"], "definition": "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]", "canonical_name": "blood vessel formation from pre-existing blood vessels"}
{"concept_id": "C0302820", "aliases": ["carbohydrate metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732]", "canonical_name": "carbohydrate metabolism"}
{"concept_id": "C0312431", "aliases": [], "types": ["T042"], "definition": "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. [ISBN:0198506732]", "canonical_name": "hormone secretion"}
{"concept_id": "C0312860", "aliases": [], "types": ["T043"], "definition": "The movement of a neutrophil within or between different tissues and organs of the body. [PMID:1826836]", "canonical_name": "neutrophil migration"}
{"concept_id": "C0312861", "aliases": [], "types": ["T043"], "definition": "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:jl, ISBN:0198506732]", "canonical_name": "neutrophil chemotaxis"}
{"concept_id": "C0312862", "aliases": [], "types": ["T043"], "definition": "The directed movement of a lymphocyte in response to an external stimulus. [GOC:hjd, GOC:jid, PMID:12391252]", "canonical_name": "lymphocyte chemotaxis"}
{"concept_id": "C0333904", "aliases": ["pyknosis"], "types": ["T043"], "definition": "The compaction of chromatin during apoptosis. [GOC:mah]", "canonical_name": "apoptotic chromosome condensation"}
{"concept_id": "C0334024", "aliases": [], "types": ["T042"], "definition": "Formation of CORPUS LUTEUM. This process includes capillary invasion of the ruptured OVARIAN FOLLICLE, hypertrophy of the GRANULOSA CELLS and the THECA CELLS, and the production of PROGESTERONE. Luteinization is regulated by LUTEINIZING HORMONE.", "canonical_name": "luteinization"}
{"concept_id": "C0334040", "aliases": [], "types": ["T046"], "definition": "Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division. [GO_REF:0000034]", "canonical_name": "metaplastic ossification"}
{"concept_id": "C0376322", "aliases": ["protein glycosylation"], "types": ["T044"], "definition": "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:curators, GOC:pr]", "canonical_name": "protein amino acid glycosylation"}
{"concept_id": "C0376437", "aliases": [], "types": ["T045"], "definition": "The excision of in-frame internal protein sequences (INTEINS) of a precursor protein, coupled with ligation of the flanking sequences (EXTEINS). Protein splicing is an autocatalytic reaction and results in the production of two proteins from a single primary translation product: the intein and the mature protein.", "canonical_name": "protein splicing"}
{"concept_id": "C0376451", "aliases": [], "types": ["T043"], "definition": "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. [GOC:go_curators]", "canonical_name": "phototransduction"}
{"concept_id": "C0376452", "aliases": [], "types": ["T044"], "definition": "Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.", "canonical_name": "DNA methylation"}
{"concept_id": "C0376628", "aliases": [], "types": ["T049"], "definition": "A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.", "canonical_name": "chromosome breakage"}
{"concept_id": "C0376669", "aliases": [], "types": ["T044"], "definition": "Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.", "canonical_name": "DNA fragmentation"}
{"concept_id": "C0423909", "aliases": [], "types": ["T041"], "definition": "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]", "canonical_name": "long-term memory"}
{"concept_id": "C0427509", "aliases": ["phosphoenol transphosphorylase activity", "pyruvate kinase activity", "phosphoenolpyruvate kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: = ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate. [EC:2.7.1.40, RHEA:18159]", "canonical_name": "ATP:pyruvate 2-O-phosphotransferase activity"}
{"concept_id": "C0427970", "aliases": ["ampicillinase activity", "exopenicillinase activity", "beta-lactam hydrolase activity", "beta-lactamase activity", "penicillin amido-beta-lactamhydrolase activity", "penicillin beta-lactamase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. [EC:3.5.2.6]", "canonical_name": "cephalosporin-beta-lactamase activity"}
{"concept_id": "C0429098", "aliases": ["electrocardiogram QRS complex"], "types": ["T033"], "canonical_name": "electrocardiogram QRS complex"}
{"concept_id": "C0429104", "aliases": [], "types": ["T201"], "canonical_name": "electrocardiogram T wave"}
{"concept_id": "C0439840", "aliases": [], "types": ["T042"], "definition": "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. [GOC:dph, ISBN:0877797099]", "canonical_name": "reflex"}
{"concept_id": "C0442692", "aliases": [], "types": ["T039"], "definition": "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. [GOC:dph, GOC:isa_complete]", "canonical_name": "reproductive process"}
{"concept_id": "C0443616", "aliases": [], "types": ["T116"], "definition": "Metabolic products of chylomicron particles in which TRIGLYCERIDES have been selectively removed by the LIPOPROTEIN LIPASE. These remnants carry dietary lipids in the blood and are cholesterol-rich. Their interactions with MACROPHAGES; ENDOTHELIAL CELLS; and SMOOTH MUSCLE CELLS in the artery wall can lead to ATHEROSCLEROSIS.", "canonical_name": "chylomicron remnant"}
{"concept_id": "C0453903", "aliases": [], "types": ["T073"], "canonical_name": "girdle"}
{"concept_id": "C0474331", "aliases": ["visual behaviour", "visual behavior", "behavioral response to visual stimulus"], "types": ["T055"], "definition": "The behavior of an organism in response to a visual stimulus. [GOC:jid, GOC:pr]", "canonical_name": "behavioural response to visual stimulus"}
{"concept_id": "C0521119", "aliases": ["extracellular region"], "types": ["T026"], "definition": "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]", "canonical_name": "extracellular"}
{"concept_id": "C0521179", "aliases": [], "types": ["T026"], "definition": "Small granular inclusions (about 1-3 microns in diameter) found in the anterior horn cells, and appearing either singly or in a group. Sometimes they are arranged in small beaded chains. Bunina bodies express cystatin C and consist of electron-dense amorphous material that contains tubules or vesicular structures. The amorphous material frequently includes a cytoplasmic island containing neurofilaments and other micro-organelles. [NIF_Subcellular:nlx_subcell_20090101, PMID:18026741]", "canonical_name": "Bunina body"}
{"concept_id": "C0524550", "aliases": ["pyrimidine-dimer repair, DNA damage excision", "nucleotide-excision repair"], "types": ["T045"], "definition": "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). [PMID:10197977]", "canonical_name": "NER"}
{"concept_id": "C0524663", "aliases": ["cerebellar mossy fibre"], "types": ["T023"], "definition": "An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons a mossy-looking appearance in Golgi stained preparations. [NIF_Subcellular:nlx_subcell_20090209]", "canonical_name": "cerebellar mossy fiber"}
{"concept_id": "C0524817", "aliases": [], "types": ["T023"], "definition": "Axons of certain cells in the DENTATE GYRUS. They project to the polymorphic layer of the dentate gyrus and to the proximal dendrites of PYRAMIDAL CELLS of the HIPPOCAMPUS. These mossy fibers should not be confused with mossy fibers that are cerebellar afferents (see NERVE FIBERS).", "canonical_name": "hippocampal mossy fiber"}
{"concept_id": "C0525009", "aliases": ["periplasmic space"], "types": ["T026"], "definition": "The space between the inner and outer membranes of a cell that is shared with the cell wall.", "canonical_name": "periplasm"}
{"concept_id": "C0525010", "aliases": ["autocrine signalling"], "types": ["T043"], "definition": "Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone.", "canonical_name": "autocrine signaling"}
{"concept_id": "C0525011", "aliases": ["paracrine signalling"], "types": ["T043"], "definition": "Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.", "canonical_name": "paracrine signaling"}
{"concept_id": "C0541794", "aliases": [], "types": ["T046"], "definition": "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. [GOC:mtg_muscle]", "canonical_name": "skeletal muscle atrophy"}
{"concept_id": "C0541840", "aliases": [], "types": ["T042"], "definition": "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. [GOC:mtg_cardio, GOC:mtg_muscle]", "canonical_name": "skeletal muscle contraction"}
{"concept_id": "C0542478", "aliases": ["physiological response to stimulus"], "types": ["T039"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. [GOC:ai, GOC:bf]", "canonical_name": "response to stimulus"}
{"concept_id": "C0582587", "aliases": ["visual learning"], "types": ["T041"], "definition": "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. [GOC:jid, ISBN:0582227089]", "canonical_name": "spatial learning"}
{"concept_id": "C0596074", "aliases": ["cellular amino acid anabolism", "cellular amino acid biosynthesis", "amino acid biosynthetic process", "cellular amino acid formation", "cellular amino acid synthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. [ISBN:0198506732]", "canonical_name": "cellular amino acid biosynthetic process"}
{"concept_id": "C0596076", "aliases": ["amino acid metabolic process", "amino acid and derivative metabolism", "cellular amino acid metabolic process", "cellular amino acid and derivative metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. [ISBN:0198506732]", "canonical_name": "cellular amino acid metabolism"}
{"concept_id": "C0596078", "aliases": [], "types": ["T043"], "definition": "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "canonical_name": "amino acid transport"}
{"concept_id": "C0596142", "aliases": [], "types": ["T026"], "definition": "Any chromosome other than a sex chromosome. [GOC:mah]", "canonical_name": "autosome"}
{"concept_id": "C0596233", "aliases": ["release of stored calcium ion (Ca2+)", "calcium mobilization", "release of sequestered calcium ion (Ca2+)", "release of sequestered calcium ion into cytoplasm", "calcium ion (Ca2+) mobilization", "release of stored calcium ion (Ca2+) into cytoplasm", "cytoplasmic release of sequestered calcium ion (Ca2+)"], "types": ["T043"], "definition": "large scale movement of calcium ions at the cellular level, as across the cell membrane, between organelles, or through the cytoplasm; a fundamental cellular signal transduction mechanism; do not confuse with CALCIUM METABOLISM, which applies to bodily balance.", "canonical_name": "cytoplasmic release of stored calcium ion (Ca2+)"}
{"concept_id": "C0596247", "aliases": ["carbohydrate synthesis", "anabolic carbohydrate metabolic process", "carbohydrate biosynthesis", "carbohydrate anabolism", "anabolic carbohydrate metabolism", "carbohydrate formation"], "types": ["T044"], "canonical_name": "carbohydrate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [ISBN:0198506732]"}
{"concept_id": "C0596250", "aliases": [], "types": ["T044"], "canonical_name": "sugar transport"}
{"concept_id": "C0596252", "aliases": [], "types": ["T042"], "canonical_name": "carbon dioxide fixation", "definition": "conversion of atmospheric carbon dioxide to organic carbon compounds as in photosynthesis."}
{"concept_id": "C0596254", "aliases": [], "types": ["T042"], "canonical_name": "carbon dioxide transport", "definition": "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C0596286", "aliases": [], "types": ["T043"], "definition": "Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]", "canonical_name": "regulation of cell growth"}
{"concept_id": "C0596290", "aliases": [], "types": ["T043"], "definition": "All of the processes involved in increasing CELL NUMBER including CELL DIVISION.", "canonical_name": "cell proliferation"}
{"concept_id": "C0596336", "aliases": [], "types": ["T045"], "canonical_name": "chromosome movement", "definition": "separation of chromosomes during cell division."}
{"concept_id": "C0596374", "aliases": [], "types": ["T042"], "canonical_name": "connective tissue development", "definition": "The progression of a connective tissue over time, from its formation to the mature structure. [GOC:BHF]"}
{"concept_id": "C0596433", "aliases": [], "types": ["T040"], "definition": "A period of arrested growth or development in animals that is triggered by external conditions, such as length of day, extreme temperatures, or reduced food availability. It can occur at the embryonic, larval, pupal, or adult stage, depending on the species.", "canonical_name": "diapause"}
{"concept_id": "C0596480", "aliases": ["icosanoid metabolic process", "eicosanoid metabolism", "eicosanoid metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. [GOC:ma]", "canonical_name": "icosanoid metabolism"}
{"concept_id": "C0596562", "aliases": ["fatty acid formation", "fatty acid synthesis", "fatty acid anabolism", "fatty acid biosynthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. [GOC:mah, ISBN:0198506732]", "canonical_name": "fatty acid biosynthetic process"}
{"concept_id": "C0596563", "aliases": ["fatty acid metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]", "canonical_name": "fatty acid metabolism"}
{"concept_id": "C0596564", "aliases": [], "types": ["T043"], "canonical_name": "fatty acid transport", "definition": "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [GOC:ai]"}
{"concept_id": "C0596620", "aliases": ["cellular glucose metabolic process", "glucose metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732]", "canonical_name": "glucose metabolic process"}
{"concept_id": "C0596624", "aliases": ["glycogen degradation", "glycogen breakdown", "glycogen catabolic process", "glycogenolysis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. [ISBN:0198506732]", "canonical_name": "glycogen catabolism"}
{"concept_id": "C0596625", "aliases": [], "types": ["T044"], "canonical_name": "N-glycan biosynthesis"}
{"concept_id": "C0596632", "aliases": [], "types": ["T026"], "definition": "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]", "canonical_name": "growth cone"}
{"concept_id": "C0596715", "aliases": ["hormone biosynthesis", "hormone anabolism", "hormone formation", "hormone synthesis"], "types": ["T044"], "canonical_name": "hormone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl]"}
{"concept_id": "C0596716", "aliases": ["hormone metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl]", "canonical_name": "hormone metabolic process"}
{"concept_id": "C0596735", "aliases": [], "types": ["T043"], "canonical_name": "hydrogen transport", "definition": "movement of hydrogen ions (protons) across biological membranes; may be active, passive, or facilitated."}
{"concept_id": "C0596824", "aliases": ["viral dormancy", "phage lysogeny", "viral latency"], "types": ["T038"], "definition": "The ability of a pathogenic virus to lie dormant within a cell (LATENT INFECTION). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.", "canonical_name": "latent virus infection"}
{"concept_id": "C0596843", "aliases": ["adipogenesis"], "types": ["T044"], "definition": "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. [GOC:dph]", "canonical_name": "adipose tissue development"}
{"concept_id": "C0596846", "aliases": [], "types": ["T043"], "definition": "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [ISBN:0198506732]", "canonical_name": "lipid transport"}
{"concept_id": "C0596873", "aliases": [], "types": ["T043"], "definition": "The expansion of a lymphocyte population by cell division. [GOC:ai]", "canonical_name": "lymphocyte proliferation"}
{"concept_id": "C0596898", "aliases": [], "types": ["T043"], "canonical_name": "membrane biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. [GOC:jl]"}
{"concept_id": "C0596901", "aliases": [], "types": ["T026"], "definition": "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]", "canonical_name": "membrane"}
{"concept_id": "C0596952", "aliases": [], "types": ["T026"], "definition": "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. [GOC:mah, NIF_Subcellular:sao1045389829]", "canonical_name": "mitochondrial membrane"}
{"concept_id": "C0596991", "aliases": [], "types": ["T043"], "definition": "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. [GOC:dgh, GOC:mah]", "canonical_name": "myelination"}
{"concept_id": "C0596997", "aliases": ["myogenesis"], "types": ["T043"], "definition": "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. [GOC:mtg_muscle]", "canonical_name": "skeletal muscle tissue development"}
{"concept_id": "C0597062", "aliases": ["neurotransmitter biosynthesis", "neurotransmitter biosynthetic process", "neurotransmitter formation", "neurotransmitter anabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. [GOC:jl]", "canonical_name": "neurotransmitter synthesis"}
{"concept_id": "C0597063", "aliases": ["neurotransmitter metabolism"], "types": ["T043"], "canonical_name": "neurotransmitter metabolic process", "definition": "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. [GOC:jl]"}
{"concept_id": "C0597064", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter transport", "definition": "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai]"}
{"concept_id": "C0597108", "aliases": ["nucleotide metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). [GOC:ma]", "canonical_name": "nucleotide metabolism"}
{"concept_id": "C0597131", "aliases": [], "types": ["T053"], "canonical_name": "open-field behavior", "definition": "behavior manifested and/or studied in a standardized environmental arrangement in order to study its approach-avoidance responses or signs of emotionality and locomotor activity."}
{"concept_id": "C0597140", "aliases": [], "types": ["T032"], "definition": "state of immunologic unresponsiveness induced by the prior ingestion of antigen.", "canonical_name": "oral tolerance"}
{"concept_id": "C0597157", "aliases": [], "types": ["T042"], "definition": "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "canonical_name": "oxygen transport"}
{"concept_id": "C0597190", "aliases": [], "types": ["T026"], "definition": "The structure enclosing certain parasite cells such as certain apicomplexa and Euglenozoa; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles. [GOC:mah, GOC:mb]", "canonical_name": "pellicle"}
{"concept_id": "C0597223", "aliases": ["phosphorus metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). [GOC:ai]", "canonical_name": "phosphorus metabolic process"}
{"concept_id": "C0597230", "aliases": [], "types": ["T040"], "canonical_name": "photoprotection", "definition": "Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis. [GOC:mg]"}
{"concept_id": "C0597234", "aliases": [], "types": ["T026"], "canonical_name": "photosystem", "definition": "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949]"}
{"concept_id": "C0597271", "aliases": ["porphyrin biosynthetic process", "porphyrin synthesis", "porphyrin formation", "porphyrin anabolism"], "types": ["T044"], "canonical_name": "porphyrin biosynthesis", "definition": "anabolic formation of porphyrins in organisms or living cells."}
{"concept_id": "C0597272", "aliases": ["porphyrin metabolic process"], "types": ["T044"], "canonical_name": "porphyrin metabolism", "definition": "sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosynthesis) and catabolism of porphyrins; the buildup and breakdown of porphyrins for utilization by the organism."}
{"concept_id": "C0597295", "aliases": ["protein biosynthetic process", "protein anabolism", "translation", "protein synthesis", "protein translation", "protein biosynthesis"], "types": ["T044"], "definition": "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]", "canonical_name": "protein formation"}
{"concept_id": "C0597299", "aliases": ["protein metabolic process and modification", "cellular protein metabolic process", "protein metabolism and modification", "protein metabolic process", "cellular protein metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving a protein. Includes protein modification. [GOC:ma]", "canonical_name": "protein metabolism"}
{"concept_id": "C0597304", "aliases": ["peptidolysis"], "types": ["T044"], "definition": "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]", "canonical_name": "proteolysis"}
{"concept_id": "C0597358", "aliases": [], "types": ["T044"], "definition": "Receptor Binding involves a temporary non-covalent, typically highly specific and high affinity, interaction through intermolecular physical forces of attraction and spatial complementarity with a diverse group of intrinsic membrane or cytoplasmic proteins that mediate the biological effects of secreted regulatory signaling molecules through modification of the activity of signal transduction pathways.", "canonical_name": "receptor binding"}
{"concept_id": "C0597361", "aliases": ["receptor-mediated endocytosis"], "types": ["T043"], "definition": "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. [GOC:mah, ISBN:0716731363]", "canonical_name": "receptor mediated endocytosis"}
{"concept_id": "C0597415", "aliases": [], "types": ["T045"], "canonical_name": "RNA methylation", "definition": "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. [GOC:hjd, PMID:21823225]"}
{"concept_id": "C0597513", "aliases": ["steroidogenesis", "steroid biosynthetic process", "steroid anabolism", "steroid biosynthesis", "steroid formation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. [GOC:go_curators]", "canonical_name": "steroid synthesis"}
{"concept_id": "C0597520", "aliases": ["steroid metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]", "canonical_name": "steroid metabolism"}
{"concept_id": "C0597538", "aliases": ["sulfonation", "sulphur addition", "sulfur addition", "sulphation"], "types": ["T067"], "definition": "The addition of a sulfate group to a molecule. [Wikipedia:Sulfation]", "canonical_name": "sulfation"}
{"concept_id": "C0597545", "aliases": ["synapse biogenesis", "synaptogenesis"], "types": ["T042"], "definition": "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). [GOC:mah]", "canonical_name": "synapse assembly"}
{"concept_id": "C0597595", "aliases": ["toxin metabolism"], "types": ["T044"], "canonical_name": "toxin metabolic process", "definition": "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. [GOC:cab2]"}
{"concept_id": "C0597601", "aliases": [], "types": ["T043"], "definition": "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. [ISBN:0716731363]", "canonical_name": "transcytosis"}
{"concept_id": "C0597619", "aliases": ["urea biosynthesis", "ornithine cycle", "urea cycle"], "types": ["T044"], "definition": "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate. [GOC:pde, GOC:vw, ISBN:0198506732]", "canonical_name": "urea biosynthetic process"}
{"concept_id": "C0597640", "aliases": [], "types": ["T042"], "canonical_name": "vasomotion", "definition": "The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm. [GOC:sl, PMID:14993429, PMID:15678091, PMID:1932763]"}
{"concept_id": "C0597663", "aliases": ["phototransduction, visible light", "visual cascade"], "types": ["T043"], "definition": "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. [GOC:go_curators, ISBN:0198506732]", "canonical_name": "visual transduction"}
{"concept_id": "C0597669", "aliases": ["vitamin synthesis", "vitamin anabolism", "vitamin formation", "vitamin biosynthesis"], "types": ["T044"], "canonical_name": "vitamin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C0597672", "aliases": ["vitamin metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. [GOC:ai]", "canonical_name": "vitamin metabolism"}
{"concept_id": "C0597704", "aliases": ["protein localization", "protein localisation", "cellular protein localization", "cellular protein localisation"], "types": ["T043"], "definition": "Any process in which a protein is transported to, or maintained in, a specific location. [GOC:ai]", "canonical_name": "establishment and maintenance of protein localization"}
{"concept_id": "C0597729", "aliases": ["SPB"], "types": ["T026"], "definition": "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome. [ISBN:0879693568]", "canonical_name": "spindle pole body"}
{"concept_id": "C0598016", "aliases": [], "types": ["T040"], "definition": "The emergence of an immature organism from a protective structure. [GOC:dgh, GOC:isa_complete, ISBN:0198612001]", "canonical_name": "hatching"}
{"concept_id": "C0598067", "aliases": ["cartilage organ development", "cartilage biogenesis", "cartilage formation", "cartilage development", "cartilage biosynthesis", "chondrogenesis"], "types": ["T042"], "definition": "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:cjm, PMID:23251424]", "canonical_name": "cartilage element development"}
{"concept_id": "C0598083", "aliases": ["Remak nuclear division", "direct nuclear division"], "types": ["T043"], "canonical_name": "amitosis", "definition": "Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation. [GOC:curators, ISBN:0721662544]"}
{"concept_id": "C0598087", "aliases": [], "types": ["T043"], "definition": "A reverse developmental process in which terminally differentiated cells with specialized functions revert back to a less differentiated stage within their own CELL LINEAGE.", "canonical_name": "cell dedifferentiation"}
{"concept_id": "C0598099", "aliases": [], "types": ["T026"], "canonical_name": "cell envelope", "definition": "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm]"}
{"concept_id": "C0598175", "aliases": ["chromosome segregation"], "types": ["T045"], "definition": "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]", "canonical_name": "chromosome division"}
{"concept_id": "C0598267", "aliases": [], "types": ["T026"], "definition": "Granule free cytoplasm, lying immediately below the plasma membrane. [GOC:curators, PMID:12211103]", "canonical_name": "ectoplasm"}
{"concept_id": "C0598282", "aliases": [], "types": ["T042"], "definition": "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]", "canonical_name": "nervous system development"}
{"concept_id": "C0598312", "aliases": [], "types": ["T045"], "definition": "The process by which a DNA molecule is duplicated.", "canonical_name": "DNA replication"}
{"concept_id": "C0598496", "aliases": [], "types": ["T045"], "definition": "Interruption or suppression of the expression of a gene at transcriptional or translational levels.", "canonical_name": "gene silencing"}
{"concept_id": "C0598501", "aliases": ["synapsis", "chromosomal synapsis", "homologous chromosome pairing at meiosis"], "types": ["T043"], "definition": "The alignment of CHROMOSOMES at homologous sequences.", "canonical_name": "chromosomal pairing"}
{"concept_id": "C0598720", "aliases": [], "types": ["T043"], "definition": "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "canonical_name": "RNA transport"}
{"concept_id": "C0598773", "aliases": [], "types": ["T043"], "canonical_name": "leukocyte proliferation", "definition": "The expansion of a leukocyte population by cell division. [GOC:add]"}
{"concept_id": "C0598783", "aliases": ["lipid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]", "canonical_name": "lipid metabolic process"}
{"concept_id": "C0598838", "aliases": [], "types": ["T043"], "canonical_name": "membrane assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a membrane. [GOC:mah]"}
{"concept_id": "C0598864", "aliases": [], "types": ["T044"], "definition": "The process of removing one or more methyl groups from a molecule. [GOC:BHF, GOC:rl]", "canonical_name": "demethylation"}
{"concept_id": "C0598956", "aliases": [], "types": ["T043"], "canonical_name": "slow axonal transport", "definition": "The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition. [PMID:6378920]"}
{"concept_id": "C0598962", "aliases": ["neurotransmitter import into glial cell", "neurotransmitter recycling", "neurotransmitter import", "neurotransmitter import into neuron", "neurotransmitter reuptake"], "types": ["T038"], "canonical_name": "neurotransmitter uptake", "definition": "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]"}
{"concept_id": "C0598964", "aliases": ["neurotransmitter secretory pathway", "neurotransmitter secretion"], "types": ["T043"], "definition": "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. [GOC:dph]", "canonical_name": "neurotransmitter release"}
{"concept_id": "C0599130", "aliases": ["autotrophy", "carbon fixation", "autotrophic CO2 fixation"], "types": ["T044"], "definition": "A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). [GOC:jl, GOC:mah]", "canonical_name": "autotrophic CO2 fixation pathway"}
{"concept_id": "C0599131", "aliases": [], "types": ["T026"], "definition": "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949]", "canonical_name": "photosystem I"}
{"concept_id": "C0599132", "aliases": [], "types": ["T026"], "definition": "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949]", "canonical_name": "photosystem II"}
{"concept_id": "C0599175", "aliases": ["heme synthesis", "haem biosynthetic process", "haem biosynthesis", "heme formation", "heme anabolism", "heme biosynthesis"], "types": ["T044"], "canonical_name": "heme biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. [GOC:jl, PMID:11788607]"}
{"concept_id": "C0599176", "aliases": ["5'-end processing", "5' mRNA capping", "5'-end mRNA processing", "5' end capping", "mRNA capping"], "types": ["T045"], "canonical_name": "7-methylguanosine mRNA capping", "definition": "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. [GOC:mah, PMID:9266685]"}
{"concept_id": "C0599281", "aliases": [], "types": ["T067"], "canonical_name": "receptor internalization", "definition": "A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]"}
{"concept_id": "C0599282", "aliases": [], "types": ["T043"], "canonical_name": "receptor recycling", "definition": "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal. [GOC:dph]"}
{"concept_id": "C0599428", "aliases": ["regulation of circadian sleep/wake cycle, sleep"], "types": ["T040"], "definition": "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. [GOC:jl, ISBN:0192800981]", "canonical_name": "regulation of sleep"}
{"concept_id": "C0599444", "aliases": ["neuronal cell body", "perikaryon", "neuronal cell soma"], "types": ["T026"], "definition": "The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]", "canonical_name": "neuron cell body"}
{"concept_id": "C0599474", "aliases": ["cholesterol anabolism", "cholesterol biosynthetic process", "cholesterol biosynthesis", "cholesterol formation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai]", "canonical_name": "cholesterol synthesis"}
{"concept_id": "C0599514", "aliases": [], "types": ["T070"], "canonical_name": "mutualism"}
{"concept_id": "C0599607", "aliases": [], "types": ["T040"], "definition": "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. [PMID:11784757]", "canonical_name": "vestibular reflex"}
{"concept_id": "C0599733", "aliases": [], "types": ["T043"], "definition": "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. [GOC:add]", "canonical_name": "cell killing"}
{"concept_id": "C0599784", "aliases": ["glycogen metabolism"], "types": ["T044"], "canonical_name": "glycogen metabolic process", "definition": "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. [ISBN:0198506732]"}
{"concept_id": "C0599814", "aliases": [], "types": ["T043"], "definition": "The directed movement of substances within a cell. [GOC:ai]", "canonical_name": "intracellular transport"}
{"concept_id": "C0599893", "aliases": ["protein transmembrane transport"], "types": ["T043"], "definition": "The process in which a protein is transported across a membrane. [GOC:mah, GOC:vw]", "canonical_name": "protein membrane transport"}
{"concept_id": "C0599895", "aliases": [], "types": ["T043"], "definition": "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "canonical_name": "protein transport"}
{"concept_id": "C0599952", "aliases": ["modulation by virus of host anatomy or process", "host-virus interaction", "modulation by virus of host process", "viral-host process", "virus-host process"], "types": ["T043"], "definition": "The process in which a virus effects a change in the structure or processes of its host organism. [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945]", "canonical_name": "viral interaction with host"}
{"concept_id": "C0600314", "aliases": [], "types": ["T026"], "canonical_name": "axopodium"}
{"concept_id": "C0600315", "aliases": [], "types": ["T026"], "definition": "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. [GOC:mah, GOC:pr, ISBN:0815316194]", "canonical_name": "filopodium"}
{"concept_id": "C0600316", "aliases": [], "types": ["T026"], "canonical_name": "lobopodium"}
{"concept_id": "C0600317", "aliases": [], "types": ["T026"], "canonical_name": "reticulopodium"}
{"concept_id": "C0600431", "aliases": ["calcium signaling", "calcium-mediated signaling", "calcium-mediated signalling", "calcium signalling"], "types": ["T043"], "definition": "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]", "canonical_name": "calcium ion signaling"}
{"concept_id": "C0600436", "aliases": [], "types": ["T044"], "definition": "Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.", "canonical_name": "base pairing"}
{"concept_id": "C0600485", "aliases": [], "types": ["T043"], "definition": "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida. [GOC:dph, PMID:11175768, PMID:21042299, PMID:3886029]", "canonical_name": "acrosome reaction"}
{"concept_id": "C0600496", "aliases": [], "types": ["T026"], "definition": "Organelles of phototrophic bacteria which contain photosynthetic pigments and which are formed from an invagination of the cytoplasmic membrane.", "canonical_name": "chromatophore vesicle"}
{"concept_id": "C0600532", "aliases": [], "types": ["T026"], "definition": "Rod-shaped storage granules for VON WILLEBRAND FACTOR specific to endothelial cells.", "canonical_name": "Weibel-Palade body"}
{"concept_id": "C0659293", "aliases": ["tryphine", "pollen coat"], "types": ["T109"], "definition": "A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma. [GOC:mah, GOC:rph, PMID:12930826, PMID:15012271]", "canonical_name": "pollenkitt"}
{"concept_id": "C0677482", "aliases": [], "types": ["T040"], "definition": "relationship between two organisms where one (parasite) lives on or in the other (host) and derives nutrients and protection while injuring or killing the host; see RTs for specific organisms.", "canonical_name": "parasitism"}
{"concept_id": "C0678661", "aliases": [], "types": ["T038"], "definition": "Any process that modulates a measurable attribute of any biological process, quality or function. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]", "canonical_name": "biological regulation"}
{"concept_id": "C0678686", "aliases": [], "types": ["T039"], "canonical_name": "dormancy"}
{"concept_id": "C0678701", "aliases": ["ethanol metabolic process"], "types": ["T040"], "definition": "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. [GOC:ai, ISBN:0198506732]", "canonical_name": "ethanol metabolism"}
{"concept_id": "C0678705", "aliases": ["acetate catabolism", "acetate degradation", "acetate breakdown"], "types": ["T044"], "canonical_name": "acetate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. [GOC:go_curators]"}
{"concept_id": "C0678710", "aliases": ["ethanol formation", "ethanol synthesis", "ethanol biosynthesis", "ethanol anabolism"], "types": ["T040"], "canonical_name": "ethanol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C0678714", "aliases": ["bile acid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:go_curators]", "canonical_name": "bile acid metabolic process"}
{"concept_id": "C0678723", "aliases": [], "types": ["T040"], "definition": "The act, or process, of natural progression in physical and psychological maturation from a previous, lower, or embryonic stage to a later, more complex, or adult stage.", "canonical_name": "development"}
{"concept_id": "C0678836", "aliases": ["recognition of surroundings by cell"], "types": ["T043"], "canonical_name": "cell recognition", "definition": "The process in which a cell in an organism interprets its surroundings. [GOC:go_curators]"}
{"concept_id": "C0678851", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial transport", "definition": "Transport of substances into, out of or within a mitochondrion. [GOC:ai]"}
{"concept_id": "C0678863", "aliases": ["regulation of blood pressure"], "types": ["T040"], "definition": "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]", "canonical_name": "blood pressure regulation"}
{"concept_id": "C0678876", "aliases": [], "types": ["T042"], "canonical_name": "renal tubular secretion", "definition": "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion]"}
{"concept_id": "C0678896", "aliases": ["endocrine process", "endocrine physiological process"], "types": ["T039"], "definition": "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. [ISBN:0721662544]", "canonical_name": "endocrine physiology"}
{"concept_id": "C0679032", "aliases": ["detection of temperature stimulus", "detection of thermal stimulus", "detection of temperature"], "types": ["T040"], "definition": "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. [GOC:hb]", "canonical_name": "perception of temperature"}
{"concept_id": "C0679081", "aliases": [], "types": ["T041"], "definition": "Learning that occurs through observing the behavior of others. [GOC:dos, Wikipedia:Observational_learning&oldid=603524137]", "canonical_name": "observational learning"}
{"concept_id": "C0682537", "aliases": [], "types": ["T026"], "definition": "That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]", "canonical_name": "nucleoplasm"}
{"concept_id": "C0682566", "aliases": [], "types": ["T026"], "definition": "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. [ISBN:0198547684]", "canonical_name": "sarcoplasm"}
{"concept_id": "C0682685", "aliases": [], "types": ["T026"], "definition": "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm]", "canonical_name": "synaptic cleft"}
{"concept_id": "C0683140", "aliases": ["drug metabolic process"], "types": ["T044"], "definition": "A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance from the body. Drug metabolism occurs in two phases: Phase I (biotransformation) involves oxidation, hydroxylation reduction, and hydrolysis. Phase II (conjugation) involves synthesis and conjugation.", "canonical_name": "drug metabolism"}
{"concept_id": "C0683142", "aliases": ["DNA metabolism", "cellular DNA metabolism"], "types": ["T045"], "canonical_name": "DNA metabolic process", "definition": "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. [ISBN:0198506732]"}
{"concept_id": "C0683143", "aliases": ["RNA metabolism"], "types": ["T045"], "canonical_name": "RNA metabolic process", "definition": "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. [ISBN:0198506732]"}
{"concept_id": "C0683145", "aliases": ["zygote formation"], "types": ["T040"], "canonical_name": "zygote formation"}
{"concept_id": "C0683154", "aliases": [], "types": ["T038"], "canonical_name": "response to drug"}
{"concept_id": "C0683184", "aliases": ["sensory transduction", "sensory detection of stimulus", "sensory perception, stimulus detection", "sensory perception, sensory transduction of stimulus"], "types": ["T042"], "canonical_name": "detection of stimulus involved in sensory perception", "definition": "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos, GOC:dph]"}
{"concept_id": "C0683230", "aliases": [], "types": ["T045"], "definition": "The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. [ISBN:0721601464]", "canonical_name": "DNA amplification"}
{"concept_id": "C0684215", "aliases": ["intercalated disc"], "types": ["T026"], "definition": "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. [GOC:mtg_muscle, PMID:11732910]", "canonical_name": "intercalated disk"}
{"concept_id": "C0699040", "aliases": ["cell surface", "cell associated"], "types": ["T026"], "definition": "The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]", "canonical_name": "cell bound"}
{"concept_id": "C0699748", "aliases": [], "types": ["T046"], "definition": "OBSOLETE. The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism. [GOC:go_curators]", "canonical_name": "pathogenesis"}
{"concept_id": "C0699900", "aliases": ["catabolic process", "breakdown", "catabolism"], "types": ["T040"], "definition": "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. [ISBN:0198547684]", "canonical_name": "degradation"}
{"concept_id": "C0751960", "aliases": [], "types": ["T026"], "definition": "The pigmented membrane of any thylakoid. [GOC:jl, GOC:pr]", "canonical_name": "thylakoid membrane"}
{"concept_id": "C0751961", "aliases": [], "types": ["T026"], "definition": "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. [GOC:ds, GOC:mtg_sensu, ISBN:0198506732]", "canonical_name": "thylakoid"}
{"concept_id": "C0751972", "aliases": ["Cajal body"], "types": ["T026"], "definition": "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]", "canonical_name": "coiled body"}
{"concept_id": "C0752063", "aliases": [], "types": ["T026"], "definition": "Microbodies which occur in animal and plant cells and in certain fungi and protozoa. They contain peroxidase, catalase, and allied enzymes. (From Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2nd ed)", "canonical_name": "peroxisome"}
{"concept_id": "C0752265", "aliases": ["extended fibrils"], "types": ["T026"], "definition": "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins. [PMID:27026396]", "canonical_name": "microfibril"}
{"concept_id": "C0752319", "aliases": ["MAPKKK cascade", "MAPK signal transduction", "MAPK cascade", "MAP kinase cascade", "mitogen-activated protein kinase cascade"], "types": ["T044"], "definition": "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267]", "canonical_name": "MAP kinase kinase kinase cascade"}
{"concept_id": "C0814002", "aliases": ["nervous system cell generation"], "types": ["T040"], "definition": "Generation of cells within the nervous system. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]", "canonical_name": "neurogenesis"}
{"concept_id": "C0815081", "aliases": [], "types": ["T040"], "canonical_name": "animal organ regeneration", "definition": "The regrowth of a lost or destroyed animal organ. [GOC:mah]"}
{"concept_id": "C0815089", "aliases": [], "types": ["T043"], "definition": "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:go_curators]", "canonical_name": "cell development"}
{"concept_id": "C0815102", "aliases": [], "types": ["T041"], "canonical_name": "conditioned place preference", "definition": "The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug. [PMID:21549821]"}
{"concept_id": "C0815105", "aliases": [], "types": ["T041"], "definition": "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus. [GOC:dph, PMID:9920659]", "canonical_name": "conditioned taste aversion"}
{"concept_id": "C0870742", "aliases": ["interspecies interaction", "interaction with another species", "interspecies interaction with other organisms", "interspecies interaction between organisms"], "types": ["T054"], "canonical_name": "biological process involved in interspecies interaction between organisms", "definition": "Any process evolved to enable an interaction with an organism of a different species. [GOC:cc]"}
{"concept_id": "C0871125", "aliases": ["pre-pulse inhibition", "PPI"], "types": ["T039"], "definition": "The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. [GOC:dph, PMID:10341260]", "canonical_name": "prepulse inhibition"}
{"concept_id": "C0871354", "aliases": [], "types": ["T040"], "definition": "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). [Wikipedia:Sexual_reproduction]", "canonical_name": "sexual reproduction"}
{"concept_id": "C0872070", "aliases": ["nucleocytoplasmic transport"], "types": ["T043"], "definition": "The directed movement of molecules between the nucleus and the cytoplasm. [GOC:go_curators]", "canonical_name": "nucleocytoplasmic shuttling"}
{"concept_id": "C0872097", "aliases": ["detachment induced cell death", "suspension induced apoptosis"], "types": ["T043"], "definition": "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix. [GOC:jl, http://www.copewithcytokines.de/]", "canonical_name": "anoikis"}
{"concept_id": "C0872161", "aliases": [], "types": ["T040"], "canonical_name": "embryonic cleavage", "definition": "The first few specialized divisions of an activated animal egg. [GOC:clt, ISBN:0070524300]"}
{"concept_id": "C0872341", "aliases": ["dendritic spine"], "types": ["T026"], "definition": "A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln]", "canonical_name": "dendrite spine"}
{"concept_id": "C0872366", "aliases": [], "types": ["T067"], "canonical_name": "sialylation", "definition": "The covalent attachment of sialic acid to a substrate molecule. [GOC:cjm]"}
{"concept_id": "C0886515", "aliases": [], "types": ["T026"], "definition": "Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.", "canonical_name": "secretory vesicle"}
{"concept_id": "C0887838", "aliases": ["Golgi trans face", "Golgi trans-face", "trans-Golgi network", "trans Golgi network"], "types": ["T026"], "definition": "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. [GOC:vw, ISBN:0815316194]", "canonical_name": "TGN"}
{"concept_id": "C0887839", "aliases": ["nuclear import", "substance nuclear import"], "types": ["T043"], "definition": "The directed movement of substances into the nucleus. [GOC:ai]", "canonical_name": "import into nucleus"}
{"concept_id": "C0887840", "aliases": ["substance nuclear export", "nucleus export", "export from nucleus"], "types": ["T043"], "definition": "The directed movement of substances out of the nucleus. [GOC:ai]", "canonical_name": "nuclear export"}
{"concept_id": "C0887868", "aliases": [], "types": ["T026"], "definition": "Detergent-insoluble CELL MEMBRANE components. They are enriched in SPHINGOLIPIDS and CHOLESTEROL and clustered with glycosyl-phosphatidylinositol (GPI)-anchored proteins.", "canonical_name": "membrane microdomain"}
{"concept_id": "C0887869", "aliases": ["cell-matrix junction", "cell-matrix adhesion"], "types": ["T026"], "definition": "The binding of a cell to the extracellular matrix via adhesion molecules. [GOC:hb]", "canonical_name": "cell-substrate junction"}
{"concept_id": "C0887870", "aliases": ["focal adhesion", "focal contact", "hemi-adherens junction", "connecting hemi-adherens junction"], "types": ["T026"], "definition": "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]", "canonical_name": "HAJ"}
{"concept_id": "C0887872", "aliases": ["cell-cell adherens junction"], "types": ["T026"], "definition": "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]", "canonical_name": "adherens junction"}
{"concept_id": "C0887879", "aliases": [], "types": ["T026"], "definition": "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. [GOC:krc, GOC:mah]", "canonical_name": "cell projection membrane"}
{"concept_id": "C0887882", "aliases": ["constitutive secretory pathway transport vesicle"], "types": ["T026"], "definition": "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. [GOC:mah, PMID:22160157]", "canonical_name": "transport vesicle"}
{"concept_id": "C0887883", "aliases": ["endocytotic vesicle", "endocytic vesicle", "endocytotic transport vesicle"], "types": ["T026"], "definition": "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]", "canonical_name": "early endosome"}
{"concept_id": "C0887884", "aliases": [], "types": ["T026"], "definition": "A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]", "canonical_name": "cytoplasmic vesicle"}
{"concept_id": "C0887885", "aliases": [], "types": ["T026"], "definition": "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. [GOC:mah, PMID:11252894]", "canonical_name": "clathrin-coated vesicle"}
{"concept_id": "C0887887", "aliases": ["COPI-coated vesicle", "COPI vesicle coat", "COPI vesicle coating"], "types": ["T026"], "definition": "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. [GOC:mah, PMID:11252894]", "canonical_name": "coatomer"}
{"concept_id": "C0887888", "aliases": ["COPII-associated ER to Golgi transport vesicle", "COPII-associated vesicle", "COPII-coated vesicle"], "types": ["T026"], "definition": "A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport). [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]", "canonical_name": "COPII-coated ER to Golgi transport vesicle"}
{"concept_id": "C0887904", "aliases": ["stress fiber"], "types": ["T026"], "definition": "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. [PMID:16651381]", "canonical_name": "stress fibre"}
{"concept_id": "C0887912", "aliases": ["genetic transfer", "horizontal gene transfer"], "types": ["T045"], "definition": "The naturally occurring transmission of genetic information between organisms, related or unrelated, circumventing parent-to-offspring transmission. Horizontal gene transfer may occur via a variety of naturally occurring processes such as GENETIC CONJUGATION; GENETIC TRANSDUCTION; and TRANSFECTION. It may result in a change of the recipient organism's genetic composition (TRANSFORMATION, GENETIC).", "canonical_name": "lateral gene transfer"}
{"concept_id": "C0887941", "aliases": ["mitochondrial inheritance"], "types": ["T045"], "definition": "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton. [GOC:mcc, PMID:10873824, PMID:11389764]", "canonical_name": "mitochondrion inheritance"}
{"concept_id": "C0887944", "aliases": ["dense core granule"], "types": ["T026"], "definition": "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. [NIF_Subcellular:sao772007592, PMID:14690495]", "canonical_name": "dense core vesicle"}
{"concept_id": "C0887959", "aliases": [], "types": ["T026"], "definition": "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis. [GOC:mb]", "canonical_name": "glycosome"}
{"concept_id": "C0918262", "aliases": [], "types": ["T026"], "canonical_name": "plant cell wall"}
{"concept_id": "C0920344", "aliases": [], "types": ["T042"], "definition": "developmental process by which some axons and dendrites become bundled into fascicles.", "canonical_name": "fasciculation of neuron"}
{"concept_id": "C0920641", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine metabolism"}
{"concept_id": "C0920681", "aliases": [], "types": ["T045"], "canonical_name": "DNA annealing"}
{"concept_id": "C0949649", "aliases": [], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. [GOC:jid, ISBN:0198506732]", "canonical_name": "muscle organ development"}
{"concept_id": "C0949764", "aliases": ["RNA 3' end processing"], "types": ["T045"], "definition": "Any process involved in forming the mature 3' end of an RNA molecule. [GOC:mah]", "canonical_name": "RNA 3'-end processing"}
{"concept_id": "C0949765", "aliases": [], "types": ["T044"], "definition": "The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. [GOC:jl]", "canonical_name": "RNA polyadenylation"}
{"concept_id": "C0950151", "aliases": [], "types": ["T040"], "definition": "The period of cyclic physiological and behavior changes in non-primate female mammals that exhibit ESTRUS. The estrous cycle generally consists of 4 or 5 distinct periods corresponding to the endocrine status (PROESTRUS; ESTRUS; METESTRUS; DIESTRUS; and ANESTRUS).", "canonical_name": "estrous cycle"}
{"concept_id": "C0971859", "aliases": [], "types": ["T042"], "definition": "The increase in size or mass of a bone that contributes to the shaping of that bone. [GOC:dos]", "canonical_name": "bone growth"}
{"concept_id": "C1120859", "aliases": [], "types": ["T116", "T126"], "canonical_name": "M-calpain"}
{"concept_id": "C1123009", "aliases": ["vascular morphogenesis"], "types": ["T042"], "canonical_name": "vasculogenesis", "definition": "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. [PMID:8999798]"}
{"concept_id": "C1135842", "aliases": ["plasmodesma"], "types": ["T026"], "definition": "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. [PMID:29880547]", "canonical_name": "plasmodesmata"}
{"concept_id": "C1135918", "aliases": [], "types": ["T025"], "definition": "An elongated spindle-shaped contractile cell, peculiar to an involuntary muscle, containing a single nucleus and longitudinally arranged myofibrils.", "canonical_name": "smooth muscle contractile fiber"}
{"concept_id": "C1135945", "aliases": [], "types": ["T026"], "definition": "The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. [GOC:cjm, MP:0009831]", "canonical_name": "sperm midpiece"}
{"concept_id": "C1136031", "aliases": ["RNAi", "posttranscriptional gene silencing by RNA", "RNA interference", "quelling", "PTGS", "post-transcriptional gene silencing by RNA", "RNA-mediated posttranscriptional gene silencing", "post-transcriptional gene silencing", "posttranscriptional gene silencing"], "types": ["T045"], "definition": "A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.", "canonical_name": "cosuppression"}
{"concept_id": "C1136039", "aliases": [], "types": ["T026"], "definition": "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane. [ISBN:0198506732, ISBN:0716731363]", "canonical_name": "nuclear lamina"}
{"concept_id": "C1136140", "aliases": ["long term synaptic depression", "long-term synaptic depression"], "types": ["T042"], "definition": "A persistent activity-dependent decrease in synaptic efficacy between NEURONS. It typically occurs following repeated low-frequency afferent stimulation, but it can be induced by other methods. Long-term depression appears to play a role in MEMORY.", "canonical_name": "LTD"}
{"concept_id": "C1136227", "aliases": [], "types": ["T026"], "definition": "A growth from a pollen grain down into the flower style which allows two sperm to pass, one to the ovum within the ovule, and the other to the central cell of the ovule to produce endosperm of SEEDS.", "canonical_name": "pollen tube"}
{"concept_id": "C1145676", "aliases": ["alcohol metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. [ISBN:0198506732]", "canonical_name": "alcohol metabolic process"}
{"concept_id": "C1148560", "aliases": ["molecular function"], "types": ["T044"], "canonical_name": "molecular_function", "definition": "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. [GOC:pdt]"}
{"concept_id": "C1148561", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation. [ISBN:0198506732]", "canonical_name": "anticoagulant activity"}
{"concept_id": "C1148562", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures. [GOC:jl]", "canonical_name": "antifreeze activity"}
{"concept_id": "C1148563", "aliases": ["ice nucleation inhibitor activity"], "types": ["T044"], "canonical_name": "ice nucleation inhibitor activity", "definition": "OBSOLETE. Inhibits the formation of ice crystals. [GOC:ai]"}
{"concept_id": "C1148564", "aliases": [], "types": ["T044"], "definition": "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. [ISBN:0198506732]", "canonical_name": "antioxidant activity"}
{"concept_id": "C1148565", "aliases": ["GDOR", "glutathione dehydrogenase (ascorbate) activity", "glutathione dehydroascorbate reductase activity", "DHA reductase activity", "glutathione:dehydroascorbate oxidoreductase activity", "dehydroascorbate reductase activity", "dehydroascorbic reductase activity", "dehydroascorbic acid reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide. [RHEA:24424]", "canonical_name": "glutathione:dehydroascorbic acid oxidoreductase activity"}
{"concept_id": "C1148566", "aliases": ["glutathione S-reductase activity", "GSSG reductase activity", "NADPH-glutathione reductase activity", "glutathione-disulphide reductase activity", "glutathione reductase activity", "NADPH:oxidized-glutathione oxidoreductase activity", "GSH reductase activity", "NADPH-GSSG reductase activity", "glutathione-disulfide reductase activity", "glutathione:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "glutathione-disulfide reductase (NADPH) activity", "definition": "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. [EC:1.8.1.7, ISBN:0198506732]"}
{"concept_id": "C1148567", "aliases": ["NADPH:oxidized thioredoxin oxidoreductase activity", "thioredoxin reductase (NADPH) activity", "thioredoxin-disulfide reductase activity", "thioredoxin:NADP+ oxidoreductase activity", "NADP--thioredoxin reductase activity", "NADPH--thioredoxin reductase activity", "thioredoxin disulfide reductase activity", "thioredoxin-disulphide reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide. [RHEA:20345]", "canonical_name": "NADPH2:oxidized thioredoxin oxidoreductase activity"}
{"concept_id": "C1148568", "aliases": ["apoptosis regulator activity", "regulation of apoptosis"], "types": ["T043"], "canonical_name": "regulation of apoptotic process", "definition": "Any process that modulates the occurrence or rate of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]"}
{"concept_id": "C1148569", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis activator activity", "definition": "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis. [GOC:hb]"}
{"concept_id": "C1148570", "aliases": ["apoptotic protease activator activity"], "types": ["T044"], "canonical_name": "peptidase activator activity involved in apoptotic process", "definition": "Binds to and increases the activity of a peptidase that is involved in the apoptotic process. [GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]"}
{"concept_id": "C1148571", "aliases": [], "types": ["T044"], "canonical_name": "apoptosis inhibitor activity", "definition": "OBSOLETE. The function held by products which directly block any step in the process of apoptosis. [GOC:hb]"}
{"concept_id": "C1148572", "aliases": [], "types": ["T044"], "canonical_name": "amino acid binding", "definition": "Binding to an amino acid, organic acids containing one or more amino substituents. [GOC:ai]"}
{"concept_id": "C1148573", "aliases": ["glutamic acid binding"], "types": ["T044"], "canonical_name": "glutamate binding", "definition": "Binding to glutamate, the anion of 2-aminopentanedioic acid. [GOC:ai]"}
{"concept_id": "C1148574", "aliases": ["aminoacetic acid binding", "Gly binding", "aminoethanoic acid binding"], "types": ["T044"], "canonical_name": "glycine binding", "definition": "Binding to glycine, aminoethanoic acid. [GOC:ai]"}
{"concept_id": "C1148575", "aliases": [], "types": ["T044"], "definition": "Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. [GOC:jl, ISBN:0198506732, ISBN:0721662544]", "canonical_name": "antigen binding"}
{"concept_id": "C1148576", "aliases": [], "types": ["T044"], "canonical_name": "antitoxin activity"}
{"concept_id": "C1148577", "aliases": [], "types": ["T044"], "canonical_name": "lipoprotein antitoxin", "definition": "OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it. [GOC:jl]"}
{"concept_id": "C1148578", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis. [ISBN:0198506732]", "canonical_name": "opsonin activity"}
{"concept_id": "C1148579", "aliases": [], "types": ["T044"], "canonical_name": "boron binding"}
{"concept_id": "C1148580", "aliases": [], "types": ["T044"], "canonical_name": "calcium ion binding", "definition": "Binding to a calcium ion (Ca2+). [GOC:ai]"}
{"concept_id": "C1148581", "aliases": ["calcium ion storage activity"], "types": ["T044"], "canonical_name": "calcium ion storage activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1148582", "aliases": ["sugar binding"], "types": ["T044"], "canonical_name": "carbohydrate binding", "definition": "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]"}
{"concept_id": "C1148583", "aliases": [], "types": ["T044"], "canonical_name": "polysaccharide binding", "definition": "Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:mah]"}
{"concept_id": "C1148584", "aliases": [], "types": ["T044"], "canonical_name": "cellulose binding", "definition": "Binding to cellulose. [GOC:mah]"}
{"concept_id": "C1148585", "aliases": [], "types": ["T044"], "canonical_name": "chitin binding", "definition": "Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148587", "aliases": [], "types": ["T044"], "canonical_name": "galactose binding", "definition": "Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148588", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "galactose binding lectin"}
{"concept_id": "C1148589", "aliases": [], "types": ["T044"], "canonical_name": "galactoside binding", "definition": "Binding to a glycoside in which the sugar group is galactose. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148590", "aliases": [], "types": ["T044"], "canonical_name": "glucose binding", "definition": "Binding to D- or L-enantiomers of glucose. [GOC:jl]"}
{"concept_id": "C1148591", "aliases": [], "types": ["T044"], "canonical_name": "lactose binding", "definition": "Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. [GOC:jl, ISBN:0192800981]"}
{"concept_id": "C1148594", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "mannose binding lectin"}
{"concept_id": "C1148595", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylgalactosamine lectin", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1148596", "aliases": [], "types": ["T044"], "definition": "Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. [GOC:jl, ISBN:0192800981]", "canonical_name": "mannose binding"}
{"concept_id": "C1148597", "aliases": [], "types": ["T044"], "canonical_name": "chlorophyll binding", "definition": "Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. [GOC:jl]"}
{"concept_id": "C1148598", "aliases": [], "types": ["T044"], "canonical_name": "bacteriochlorophyll binding", "definition": "Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants. [ISBN:0192800981]"}
{"concept_id": "C1148599", "aliases": [], "types": ["T044"], "canonical_name": "bacteriochlorophyll c binding", "definition": "Binding to bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria. [ISBN:0192800981]"}
{"concept_id": "C1148600", "aliases": [], "types": ["T044"], "canonical_name": "cocaine binding", "definition": "Binding to cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148601", "aliases": [], "types": ["T044"], "canonical_name": "cyclosporin A binding", "definition": "Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. [GOC:mb]"}
{"concept_id": "C1148602", "aliases": [], "types": ["T044"], "canonical_name": "macrolide binding", "definition": "Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148603", "aliases": [], "types": ["T044"], "canonical_name": "FK506 binding", "definition": "Binding to a 23-membered macrolide lactone FK506. [GOC:jl]"}
{"concept_id": "C1148604", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0)). [EC:5.2.1.8, ISBN:0198506732]", "canonical_name": "FK506-sensitive peptidyl-prolyl cis-trans isomerase"}
{"concept_id": "C1148605", "aliases": [], "types": ["T044"], "canonical_name": "phenylalkylamine binding", "definition": "Binding to phenylalkylamine or one of its derivatives. [GOC:jl]"}
{"concept_id": "C1148606", "aliases": [], "types": ["T044"], "canonical_name": "thienylcyclohexylpiperidine binding", "definition": "Binding to thienylcyclohexylpiperidine. [GOC:jl]"}
{"concept_id": "C1148607", "aliases": [], "types": ["T044"], "canonical_name": "glycosaminoglycan binding", "definition": "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148608", "aliases": ["heparan sulfate binding"], "types": ["T044"], "definition": "Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]", "canonical_name": "heparin binding"}
{"concept_id": "C1148609", "aliases": ["hyaluronic acid binding"], "types": ["T044"], "definition": "Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. [GOC:jl]", "canonical_name": "hyaluronan binding"}
{"concept_id": "C1148610", "aliases": [], "types": ["T044"], "canonical_name": "heavy metal binding", "definition": "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. [GOC:kd, GOC:mah]"}
{"concept_id": "C1148611", "aliases": ["copper binding"], "types": ["T044"], "canonical_name": "copper ion binding", "definition": "Binding to a copper (Cu) ion. [GOC:ai]"}
{"concept_id": "C1148612", "aliases": ["copper/cadmium binding"], "types": ["T044"], "canonical_name": "copper/cadmium binding", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1148613", "aliases": ["iron ion binding"], "types": ["T044"], "definition": "Binding to an iron (Fe) ion. [GOC:ai]", "canonical_name": "iron binding"}
{"concept_id": "C1148614", "aliases": [], "types": ["T044"], "canonical_name": "ferric iron binding", "definition": "Binding to a ferric iron ion, Fe(III). [GOC:ai]"}
{"concept_id": "C1148615", "aliases": [], "types": ["T044"], "canonical_name": "ferrous iron binding", "definition": "Binding to a ferrous iron ion, Fe(II). [GOC:ai]"}
{"concept_id": "C1148616", "aliases": ["haem binding"], "types": ["T044"], "canonical_name": "heme binding", "definition": "Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]"}
{"concept_id": "C1148617", "aliases": ["manganese binding", "Mn binding"], "types": ["T044"], "canonical_name": "manganese ion binding", "definition": "Binding to a manganese ion (Mn). [GOC:ai]"}
{"concept_id": "C1148618", "aliases": ["Hg ion binding", "mercury binding"], "types": ["T044"], "canonical_name": "mercury ion binding", "definition": "Binding to a mercury ion (Hg). [GOC:go_curators]"}
{"concept_id": "C1148619", "aliases": ["molybdenum binding", "Mo ion binding"], "types": ["T044"], "canonical_name": "molybdenum ion binding", "definition": "Binding to a molybdenum ion (Mo). [GOC:ai]"}
{"concept_id": "C1148620", "aliases": ["nickel binding", "Ni binding"], "types": ["T044"], "canonical_name": "nickel cation binding", "definition": "Binding to a nickel (Ni) cation. [GOC:ai]"}
{"concept_id": "C1148621", "aliases": ["zinc binding", "Zn binding"], "types": ["T044"], "canonical_name": "zinc ion binding", "definition": "Binding to a zinc ion (Zn). [GOC:ai]"}
{"concept_id": "C1148622", "aliases": [], "types": ["T044"], "definition": "Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor. [GOC:jl]", "canonical_name": "hormone binding"}
{"concept_id": "C1148623", "aliases": [], "types": ["T044"], "canonical_name": "androgen binding", "definition": "Binding to an androgen, a male sex hormone. [GOC:jl]"}
{"concept_id": "C1148624", "aliases": [], "types": ["T044"], "canonical_name": "juvenile hormone binding", "definition": "Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148625", "aliases": ["polypeptide hormone binding"], "types": ["T044"], "canonical_name": "peptide hormone binding", "definition": "Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148627", "aliases": [], "types": ["T044"], "canonical_name": "host cell extracellular matrix binding", "definition": "Binding to the extracellular matrix of a host cell. [PMID:7996163]"}
{"concept_id": "C1148628", "aliases": [], "types": ["T044"], "canonical_name": "host cell surface binding", "definition": "Binding to the surface of a host cell. [GOC:ai]"}
{"concept_id": "C1148629", "aliases": [], "types": ["T044"], "canonical_name": "host cell surface receptor binding", "definition": "Binding to a receptor on the host cell surface. [GOC:ai, PMID:11511370]"}
{"concept_id": "C1148630", "aliases": [], "types": ["T044"], "canonical_name": "isoprenoid binding", "definition": "Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [GOC:jl]"}
{"concept_id": "C1148631", "aliases": [], "types": ["T044"], "canonical_name": "retinoid binding", "definition": "Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148632", "aliases": ["retinaldehyde binding"], "types": ["T044"], "definition": "Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. [ISBN:0198506732]", "canonical_name": "retinal binding"}
{"concept_id": "C1148633", "aliases": ["11-cis retinaldehyde binding", "11-cis retinal binding"], "types": ["T044"], "definition": "Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A. [PMID:24403072]", "canonical_name": "11-cis-retinal binding"}
{"concept_id": "C1148634", "aliases": ["all-trans retinaldehyde binding", "trans retinal binding", "visual yellow binding"], "types": ["T044"], "definition": "Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A. [GOC:curators]", "canonical_name": "all-trans retinal binding"}
{"concept_id": "C1148635", "aliases": ["vitamin A1 binding", "vitamin A1 alcohol binding"], "types": ["T044"], "canonical_name": "retinol binding", "definition": "Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. [GOC:curators]"}
{"concept_id": "C1148636", "aliases": [], "types": ["T044"], "definition": "Binding to a lipid. [GOC:ai]", "canonical_name": "lipid binding"}
{"concept_id": "C1148637", "aliases": [], "types": ["T044"], "canonical_name": "acyl-CoA or acyl binding", "definition": "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148638", "aliases": ["ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process"], "types": ["T044"], "canonical_name": "acyl carrier activity", "definition": "Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis. [GOC:jl, GOC:vw]"}
{"concept_id": "C1148640", "aliases": [], "types": ["T044"], "canonical_name": "diacylglycerol binding", "definition": "Binding to a diacylglycerol, a diester of glycerol and two fatty acids. [GOC:ma]"}
{"concept_id": "C1148641", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid binding", "definition": "Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732]"}
{"concept_id": "C1148642", "aliases": [], "types": ["T044"], "definition": "Phospholipid Interaction involves the molecular interaction between a phospholipid molecule and a macromolecule (usually protein) for transport, catalysis, localization, or modification of function.", "canonical_name": "phospholipid binding"}
{"concept_id": "C1148643", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent phospholipid binding", "definition": "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. [GOC:jl]"}
{"concept_id": "C1148644", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylethanolamine binding", "definition": "Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. [ISBN:0198506732]"}
{"concept_id": "C1148645", "aliases": ["phosphoinositide binding"], "types": ["T044"], "canonical_name": "phosphatidylinositol binding", "definition": "Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417]"}
{"concept_id": "C1148646", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol transporter activity"}
{"concept_id": "C1148648", "aliases": ["PtdIns(4,5)P2 binding", "phosphatidylinositol 4,5-bisphosphate binding", "PIP2 binding", "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding"], "types": ["T044"], "canonical_name": "phosphatidylinositol-4,5-bisphosphate binding", "definition": "Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. [GOC:bf, GOC:jl]"}
{"concept_id": "C1148649", "aliases": [], "types": ["T044"], "canonical_name": "phospholipid transporter activity", "definition": "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1148650", "aliases": [], "types": ["T044"], "canonical_name": "aminophospholipid transporter activity"}
{"concept_id": "C1148651", "aliases": ["phospholipid translocating ATPase activity", "phospholipid-transporting ATPase activity"], "types": ["T044"], "canonical_name": "phospholipid-translocating ATPase activity"}
{"concept_id": "C1148653", "aliases": [], "types": ["T044"], "definition": "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. [GOC:cjm, PMID:20043909, PMID:20302864]", "canonical_name": "phospholipid scramblase activity"}
{"concept_id": "C1148654", "aliases": [], "types": ["T044"], "canonical_name": "sphingolipid binding", "definition": "Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [ISBN:0198506732]"}
{"concept_id": "C1148655", "aliases": [], "types": ["T044"], "canonical_name": "sphingolipid transporter activity", "definition": "Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1148656", "aliases": ["sphingolipid floppase activity (cytosolic to exoplasmic leaftlet)", "sphingolipid-translocating ATPase activity", "sphingolipid flippase activity"], "types": ["T044"], "canonical_name": "sphingolipid floppase activity", "definition": "Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [GOC:ai, PMID:12034738]"}
{"concept_id": "C1148657", "aliases": ["triacylglycerol binding"], "types": ["T044"], "canonical_name": "triglyceride binding", "definition": "Binding to a triester of glycerol. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1148658", "aliases": ["LPS binding"], "types": ["T044"], "canonical_name": "lipopolysaccharide binding", "definition": "Binding to a lipopolysaccharide. [PMID:11079463]"}
{"concept_id": "C1148659", "aliases": ["magnesium binding", "Mg binding"], "types": ["T044"], "canonical_name": "magnesium ion binding", "definition": "Binding to a magnesium (Mg) ion. [GOC:ai]"}
{"concept_id": "C1148660", "aliases": [], "types": ["T044"], "canonical_name": "neurotransmitter binding", "definition": "Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [ISBN:0198506732]"}
{"concept_id": "C1148661", "aliases": [], "types": ["T044"], "canonical_name": "acetylcholine binding", "definition": "Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai]"}
{"concept_id": "C1148662", "aliases": [], "types": ["T044"], "definition": "Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "acetylcholine receptor activity"}
{"concept_id": "C1148663", "aliases": ["muscarinic acetylcholine receptor activity", "G protein coupled acetylcholine receptor activity", "G protein-coupled acetylcholine receptor activity", "acetylcholine receptor activity, G-protein coupled", "metabotropic acetylcholine receptor activity"], "types": ["T044"], "definition": "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:fj, GOC:mah]", "canonical_name": "G-protein coupled acetylcholine receptor activity"}
{"concept_id": "C1148665", "aliases": ["acetylcholine-gated cation-selective channel activity", "nAChR", "nicotinic acetylcholine-activated cation-selective channel activity", "acetylcholine-gated cation channel activity", "acetylcholine-activated cation-selective channel activity", "nicotinergic acetylcholine receptor activity"], "types": ["T044"], "definition": "Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. [GOC:mah, PMID:2466967]", "canonical_name": "ionotropic acetylcholine receptor activity"}
{"concept_id": "C1148667", "aliases": [], "types": ["T044"], "definition": "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "neurotransmitter receptor activity"}
{"concept_id": "C1148668", "aliases": ["4-aminobutanoate receptor activity", "4-aminobutyrate receptor activity", "GABA receptor activity", "GABA binding", "gamma-aminobutyric acid receptor activity", "gamma-aminobutyric acid binding"], "types": ["T044"], "definition": "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. [GOC:jl, GOC:signaling, PMID:10637650]", "canonical_name": "gamma-aminobutyrate binding"}
{"concept_id": "C1148669", "aliases": ["ionotropic GABA receptor activity"], "types": ["T044"], "definition": "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. [PMID:8974333]", "canonical_name": "GABA-A receptor activity"}
{"concept_id": "C1148670", "aliases": [], "types": ["T044"], "definition": "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. [GOC:jl]", "canonical_name": "benzodiazepine receptor activity"}
{"concept_id": "C1148671", "aliases": [], "types": ["T044"], "canonical_name": "GABA-B receptor activity"}
{"concept_id": "C1148672", "aliases": [], "types": ["T045"], "definition": "Binding to a nucleic acid. [GOC:jl]", "canonical_name": "nucleic acid binding"}
{"concept_id": "C1148673", "aliases": [], "types": ["T045"], "definition": "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]", "canonical_name": "DNA binding"}
{"concept_id": "C1148674", "aliases": ["AT DNA binding", "AT binding", "AT-rich DNA binding"], "types": ["T045"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "minor groove of adenine-thymine-rich DNA binding"}
{"concept_id": "C1148675", "aliases": [], "types": ["T045"], "canonical_name": "bent DNA binding", "definition": "Binding to DNA in a bent conformation. [GOC:jl, PMID:12627977]"}
{"concept_id": "C1148676", "aliases": ["centromere binding"], "types": ["T045"], "canonical_name": "centromeric DNA binding", "definition": "Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. [GOC:jl, SO:0000577]"}
{"concept_id": "C1148677", "aliases": [], "types": ["T045"], "canonical_name": "chromatin binding", "definition": "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]"}
{"concept_id": "C1148678", "aliases": ["lamin/chromatin binding"], "types": ["T045"], "canonical_name": "lamin/chromatin binding", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1148679", "aliases": [], "types": ["T045"], "canonical_name": "damaged DNA binding", "definition": "Binding to damaged DNA. [GOC:jl]"}
{"concept_id": "C1148680", "aliases": ["PhrB photolyase activity", "CPD photolyase activity", "phr A photolyase activity", "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity", "deoxyribonucleate pyrimidine dimer lyase (photosensitive)", "deoxyribonucleic cyclobutane dipyrimidine photolyase activity", "deoxyribodipyrimidine photo-lyase activity", "photolyase activity", "DNA cyclobutane dipyrimidine photolyase activity", "deoxyribodipyrimidine photolyase activity", "deoxyribonucleic photolyase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. [EC:4.1.99.3]", "canonical_name": "dipyrimidine photolyase (photosensitive)"}
{"concept_id": "C1148681", "aliases": ["DNA glycosylase activity"], "types": ["T045"], "definition": "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. [GOC:elh, PMID:11554296]", "canonical_name": "DNA N-glycosylase activity"}
{"concept_id": "C1148682", "aliases": ["AlkA", "3-methyladenine DNA glycosylase II", "DNA glycosidase II activity", "alkylbase DNA glycosidase activity", "alkylbase DNA N-glycosylase activity", "DNA-3-methyladenine glycosylase II"], "types": ["T045"], "definition": "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623]", "canonical_name": "DNA-3-methyladenine glycosidase II activity"}
{"concept_id": "C1148683", "aliases": ["DNA-3-methyladenine glycosidase I activity", "DNA-3-methyladenine glycosylase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623]", "canonical_name": "DNA-3-methyladenine glycosylase I activity"}
{"concept_id": "C1148684", "aliases": [], "types": ["T045"], "canonical_name": "mismatch base pair DNA N-glycosylase activity", "definition": "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. [GOC:elh, PMID:9224623]"}
{"concept_id": "C1148685", "aliases": [], "types": ["T045"], "canonical_name": "purine-specific mismatch base pair DNA N-glycosylase activity", "definition": "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. [GOC:elh, PMID:9224623]"}
{"concept_id": "C1148686", "aliases": ["G/T-mismatch-specific thymine-DNA glycosylase activity"], "types": ["T045"], "canonical_name": "pyrimidine-specific mismatch base pair DNA N-glycosylase activity", "definition": "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site. [GOC:elh, PMID:9224623]"}
{"concept_id": "C1148687", "aliases": [], "types": ["T045"], "canonical_name": "oxidized base lesion DNA N-glycosylase activity", "definition": "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. [GOC:elh, PMID:11554296]"}
{"concept_id": "C1148688", "aliases": ["8-oxoguanine DNA glycosylase activity", "purine-specific oxidized base lesion DNA N-glycosylase activity", "DNA glycosylase/AP-lyase activity", "DNA glycosylase/beta-lyase activity"], "types": ["T045"], "canonical_name": "bifunctional DNA glycosylase activity"}
{"concept_id": "C1148689", "aliases": ["endodeoxyribonuclease III"], "types": ["T045"], "canonical_name": "endonuclease III"}
{"concept_id": "C1148690", "aliases": [], "types": ["T045"], "canonical_name": "pyrimidine dimer DNA N-glycosylase activity", "definition": "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. [GOC:elh, PMID:9224623]"}
{"concept_id": "C1148691", "aliases": ["uracil DNA N-glycosylase activity"], "types": ["T045"], "definition": "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. [GOC:elh, GOC:pr, PMID:9224623]", "canonical_name": "uracil-DNA glycosylase activity"}
{"concept_id": "C1148692", "aliases": ["single-strand selective monofunctional uracil-DNA glycosylase activity"], "types": ["T045"], "canonical_name": "single-strand selective uracil DNA N-glycosylase activity", "definition": "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA. [GOC:elh, PMID:9224623]"}
{"concept_id": "C1148693", "aliases": ["abasic deoxyendoribonuclease activity", "apyrimidinic deoxyendoribonuclease activity", "AP deoxyendoribonuclease activity", "apurinic deoxyendoribonuclease activity", "DNA-(apurinic or apyrimidinic site) endonuclease activity", "deoxyribonuclease (apurinic or apyrimidinic) activity"], "types": ["T045"], "definition": "Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). [Wikipedia:AP_endonuclease]", "canonical_name": "apurinic/apyrimidinic endodeoxyribonuclease activity"}
{"concept_id": "C1148694", "aliases": [], "types": ["T045"], "canonical_name": "excinuclease ABC activity", "definition": "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind. [GOC:mah, PMID:15192705]"}
{"concept_id": "C1148695", "aliases": ["6-O-methylguanine-DNA methyltransferase activity", "MGMT", "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity", "O-6-methylguanine-DNA-alkyltransferase activity", "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity", "methylated-DNA-protein-cysteine S-methyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. [EC:2.1.1.63]", "canonical_name": "methylated-DNA-[protein]-cysteine S-methyltransferase activity"}
{"concept_id": "C1148696", "aliases": ["DNA 3'-phosphatase activity", "deoxyribonucleate 3'-phosphatase activity", "polynucleotide 3'-phosphohydrolase activity", "polynucleotide 3'-phosphatase activity", "2'(3')-polynucleotidase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage. [EC:3.1.3.32]", "canonical_name": "5'-polynucleotidekinase 3'-phosphatase activity"}
{"concept_id": "C1148698", "aliases": [], "types": ["T045"], "definition": "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. [GOC:mah, ISBN:0198547684]", "canonical_name": "deoxyribonuclease activity"}
{"concept_id": "C1148699", "aliases": [], "types": ["T045"], "canonical_name": "caspase-activated deoxyribonuclease activity"}
{"concept_id": "C1148700", "aliases": ["DNA nicking activity"], "types": ["T045"], "definition": "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. [GOC:mah, ISBN:0198547684]", "canonical_name": "endodeoxyribonuclease activity"}
{"concept_id": "C1148701", "aliases": ["endodeoxyribonuclease activity, producing 5' phosphomonoesters"], "types": ["T045"], "canonical_name": "endodeoxyribonuclease activity, producing 5'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. [GOC:ai]"}
{"concept_id": "C1148702", "aliases": ["thymonuclease, dornase activity", "DNA endonuclease activity", "DNase activity", "alkaline DNase activity", "DNAase activity", "deoxyribonuclease I activity", "DNase I", "DNA nuclease activity", "deoxyribonucleic phosphatase activity", "DNA depolymerase activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. [EC:3.1.21.1]", "canonical_name": "alkaline deoxyribonuclease activity"}
{"concept_id": "C1148703", "aliases": ["E. coli endonuclease IV", "redoxyendonuclease activity", "DNA-adenine-transferase activity", "deoxyribonuclease IV (phage-T4-induced) activity", "endodeoxyribonuclease IV (phage T(4)-induced) activity", "endodeoxyribonuclease IV (phage T4-induced) activity", "deoxriboendonuclease activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products. [EC:3.1.21.2]", "canonical_name": "deoxyribonuclease IV (phage T4-induced) activity"}
{"concept_id": "C1148704", "aliases": ["deoxyribonuclease (adenosine triphosphate-hydrolyzing)", "ATP-dependent DNase activity", "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)", "type I restriction enzyme activity", "type I site-specific deoxyribonuclease activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. [PMID:15300241, PMID:15788748]", "canonical_name": "adenosine triphosphate-dependent deoxyribonuclease activity"}
{"concept_id": "C1148705", "aliases": ["type II site-specific deoxyribonuclease activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site. [EC:3.1.21.4, PMID:12654995]", "canonical_name": "type II restriction enzyme activity"}
{"concept_id": "C1148706", "aliases": ["type III restriction enzyme activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites. [EC:3.1.21.5, PMID:12654995]", "canonical_name": "type III site-specific deoxyribonuclease activity"}
{"concept_id": "C1148707", "aliases": ["endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters"], "types": ["T045"], "canonical_name": "endodeoxyribonuclease activity, producing 3'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. [GOC:ai]"}
{"concept_id": "C1148708", "aliases": ["Holliday junction-cleaving endonuclease activity", "endo X3", "Hje endonuclease activity", "crossover junction endoribonuclease activity", "crossover junction endodeoxyribonuclease activity", "cruciform-cutting endonuclease activity", "Holliday junction nuclease activity", "endodeoxyribonuclease RUS activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). [EC:3.1.22.4]", "canonical_name": "Endo X3 activity"}
{"concept_id": "C1148709", "aliases": ["deoxyribonuclease II activity", "acid DNase activity", "DNase II activity", "deoxyribonucleate 3'-nucleotidohydrolase activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products. [EC:3.1.22.1]", "canonical_name": "acid deoxyribonuclease activity"}
{"concept_id": "C1148711", "aliases": [], "types": ["T045"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [PMID:12444964, PMID:12928502, PMID:12941691]", "canonical_name": "endonuclease G activity"}
{"concept_id": "C1148712", "aliases": ["5' flap endonuclease activity"], "types": ["T045"], "canonical_name": "5'-flap endonuclease activity", "definition": "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. [PMID:9778254]"}
{"concept_id": "C1148713", "aliases": ["restriction endonuclease activity", "restriction enzyme activity"], "types": ["T045"], "canonical_name": "restriction endodeoxyribonuclease activity", "definition": "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. [GOC:mlg]"}
{"concept_id": "C1148714", "aliases": ["single-stranded DNA specific endodeoxyribonuclease activity", "ssDNA-specific endodeoxyribonuclease activity"], "types": ["T045"], "canonical_name": "single-stranded DNA endodeoxyribonuclease activity", "definition": "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. [GOC:mah]"}
{"concept_id": "C1148715", "aliases": [], "types": ["T045"], "canonical_name": "site-specific endodeoxyribonuclease activity, specific for altered base", "definition": "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks. [GOC:jl]"}
{"concept_id": "C1148716", "aliases": [], "types": ["T045"], "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. [GOC:mah, ISBN:0198547684]", "canonical_name": "exodeoxyribonuclease activity"}
{"concept_id": "C1148717", "aliases": ["exodeoxyribonuclease activity, producing 5' phosphomonoesters"], "types": ["T045"], "canonical_name": "exodeoxyribonuclease activity, producing 5'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. [GOC:ai]"}
{"concept_id": "C1148718", "aliases": ["3'-5' exodeoxyribonuclease activity"], "types": ["T045"], "canonical_name": "3'-5'-exodeoxyribonuclease activity", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. [GOC:mah]"}
{"concept_id": "C1148719", "aliases": ["double-stranded DNA specific 3'-5' exodeoxyribonuclease activity"], "types": ["T045"], "canonical_name": "double-stranded DNA 3'-5' exodeoxyribonuclease activity", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. [GOC:mah, PMID:22562358]"}
{"concept_id": "C1148720", "aliases": ["ssDNA-specific 3'-5' exodeoxyribonuclease activity", "single-stranded DNA specific 3'-5' exodeoxyribonuclease activity"], "types": ["T045"], "canonical_name": "single-stranded DNA 3'-5' exodeoxyribonuclease activity", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. [GOC:mah, PMID:22562358]"}
{"concept_id": "C1148721", "aliases": ["double-stranded DNA specific exodeoxyribonuclease activity"], "types": ["T045"], "canonical_name": "double-stranded DNA exodeoxyribonuclease activity", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. [GOC:mah]"}
{"concept_id": "C1148722", "aliases": [], "types": ["T045"], "definition": "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. [EC:3.1.11.1]", "canonical_name": "exodeoxyribonuclease I activity"}
{"concept_id": "C1148723", "aliases": ["exodeoxyribonuclease III activity"], "types": ["T045"], "definition": "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. [EC:3.1.11.2]", "canonical_name": "exonuclease III activity"}
{"concept_id": "C1148724", "aliases": ["gene recBC DNase activity", "RecBC deoxyribonuclease activity", "exodeoxyribonuclease V activity"], "types": ["T045"], "definition": "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. [EC:3.1.11.5]", "canonical_name": "exonuclease V activity"}
{"concept_id": "C1148725", "aliases": ["exonuclease VII activity"], "types": ["T045"], "definition": "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. [EC:3.1.11.6]", "canonical_name": "exodeoxyribonuclease VII activity"}
{"concept_id": "C1148726", "aliases": ["deoxyribonuclease X activity"], "types": ["T045"], "canonical_name": "exodeoxyribonuclease X activity", "definition": "Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes. [EC:3.1.22.5]"}
{"concept_id": "C1148727", "aliases": [], "types": ["T045"], "canonical_name": "exonuclease VIII activity"}
{"concept_id": "C1148728", "aliases": [], "types": ["T045"], "definition": "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates. [EC:3.1.13.3]", "canonical_name": "oligonucleotidase activity"}
{"concept_id": "C1148729", "aliases": [], "types": ["T045"], "definition": "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides. [PMID:11948193]", "canonical_name": "ribonuclease R activity"}
{"concept_id": "C1148730", "aliases": ["single-stranded DNA specific exodeoxyribonuclease activity", "ssDNA-specific exodeoxyribonuclease activity"], "types": ["T045"], "canonical_name": "single-stranded DNA exodeoxyribonuclease activity", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. [GOC:mah]"}
{"concept_id": "C1148731", "aliases": ["ssDNA-specific 5'-3' exodeoxyribonuclease activity", "single-stranded DNA specific 5'-3' exodeoxyribonuclease activity"], "types": ["T045"], "canonical_name": "single-stranded DNA 5'-3' exodeoxyribonuclease activity", "definition": "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. [GOC:ai, GOC:elh, PMID:20086101]"}
{"concept_id": "C1148733", "aliases": ["DNA clamp loading ATPase activity"], "types": ["T045"], "canonical_name": "DNA clamp loader activity", "definition": "Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis. [GOC:mah, GOC:vw, PMID:16082778]"}
{"concept_id": "C1148734", "aliases": [], "types": ["T045"], "canonical_name": "DNA end binding", "definition": "Binding to DNA ends exposed by the creation of double-strand breaks (DSBs). [GOC:jl]"}
{"concept_id": "C1148735", "aliases": ["ATP-dependent DNA helicase activity"], "types": ["T045"], "canonical_name": "DNA helicase activity", "definition": "Unwinding of a DNA helix, driven by ATP hydrolysis. [EC:3.6.4.12, GOC:jl]"}
{"concept_id": "C1148737", "aliases": [], "types": ["T045"], "canonical_name": "Holliday junction helicase activity"}
{"concept_id": "C1148738", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication origin binding", "definition": "Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. [GOC:curators]"}
{"concept_id": "C1148739", "aliases": [], "types": ["T045"], "canonical_name": "DNA secondary structure binding", "definition": "Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction. [GOC:krc]"}
{"concept_id": "C1148741", "aliases": ["dsDNA binding"], "types": ["T045"], "canonical_name": "double-stranded DNA binding", "definition": "Binding to double-stranded DNA. [GOC:elh, GOC:vw]"}
{"concept_id": "C1148743", "aliases": [], "types": ["T045"], "canonical_name": "double-stranded telomeric DNA binding", "definition": "Binding to double-stranded telomere-associated DNA. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1148744", "aliases": ["recombinase activity"], "types": ["T045"], "definition": "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. [GOC:elh]", "canonical_name": "DNA strand exchange activity"}
{"concept_id": "C1148745", "aliases": [], "types": ["T045"], "canonical_name": "site-specific recombinase activity", "definition": "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences. [GOC:elh, PMID:6286142]"}
{"concept_id": "C1148746", "aliases": ["site-specific tyrosine recombinase activity"], "types": ["T044"], "canonical_name": "tyrosine-based site-specific recombinase activity", "definition": "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site. [GOC:elh, PMID:11090626]"}
{"concept_id": "C1148747", "aliases": [], "types": ["T045"], "canonical_name": "left-handed Z-DNA binding", "definition": "Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags. [ISBN:0716720094]"}
{"concept_id": "C1148748", "aliases": [], "types": ["T045"], "canonical_name": "methyl-CpG binding", "definition": "Binding to a methylated cytosine/guanine dinucleotide. [GOC:jl, PMID:11746232]"}
{"concept_id": "C1148749", "aliases": [], "types": ["T045"], "canonical_name": "P-element binding", "definition": "Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis. [GOC:jl, PMID:9440262]"}
{"concept_id": "C1148753", "aliases": [], "types": ["T045"], "canonical_name": "satellite DNA binding", "definition": "Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA. [GOC:jl, SO:0000005]"}
{"concept_id": "C1148754", "aliases": ["ssDNA binding"], "types": ["T045"], "canonical_name": "single-stranded DNA binding", "definition": "Binding to single-stranded DNA. [GOC:elh, GOC:vw, PMID:22976174]"}
{"concept_id": "C1148755", "aliases": ["telomeric repeat binding", "telomere binding"], "types": ["T045"], "canonical_name": "telomeric DNA binding", "definition": "Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. [GOC:jl, SO:0000624]"}
{"concept_id": "C1148756", "aliases": [], "types": ["T045"], "definition": "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. [GOC:krc, PMID:28732250]", "canonical_name": "telomerase activity"}
{"concept_id": "C1148757", "aliases": ["telomerase, catalyst"], "types": ["T045"], "canonical_name": "telomerase RNA reverse transcriptase activity", "definition": "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template. [EC:2.7.7.49, PMID:11812242]"}
{"concept_id": "C1148758", "aliases": ["template for synthesis of G-rich strand of telomere DNA activity", "telomerase RNA"], "types": ["T045"], "definition": "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA. [PMID:11812242, PMID:7958872]", "canonical_name": "telomerase, template"}
{"concept_id": "C1148759", "aliases": ["transcription factor"], "types": ["T045"], "canonical_name": "transcription factor activity"}
{"concept_id": "C1148761", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I transcription factor activity", "definition": "OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription. [GOC:jl]"}
{"concept_id": "C1148762", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription factor activity", "definition": "OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription. [GOC:jl]"}
{"concept_id": "C1148763", "aliases": ["GTF2 activity", "basal RNA polymerase II transcription factor activity", "general RNA polymerase II transcription factor activity"], "types": ["T045"], "canonical_name": "RNA polymerase II general transcription initiation factor activity", "definition": "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]"}
{"concept_id": "C1148769", "aliases": [], "types": ["T044"], "canonical_name": "ligand-dependent nuclear receptor activity"}
{"concept_id": "C1148770", "aliases": [], "types": ["T044"], "canonical_name": "juvenile hormone receptor activity"}
{"concept_id": "C1148771", "aliases": [], "types": ["T044"], "canonical_name": "retinoic acid receptor activity"}
{"concept_id": "C1148772", "aliases": [], "types": ["T045"], "canonical_name": "RXR"}
{"concept_id": "C1148773", "aliases": [], "types": ["T044"], "canonical_name": "steroid hormone receptor activity"}
{"concept_id": "C1148774", "aliases": [], "types": ["T044"], "canonical_name": "androgen receptor activity"}
{"concept_id": "C1148775", "aliases": [], "types": ["T044"], "canonical_name": "ecdysteroid hormone receptor activity"}
{"concept_id": "C1148776", "aliases": [], "types": ["T044"], "canonical_name": "estrogen receptor activity"}
{"concept_id": "C1148777", "aliases": [], "types": ["T044"], "canonical_name": "glucocorticoid receptor activity"}
{"concept_id": "C1148779", "aliases": [], "types": ["T044"], "canonical_name": "thyroid hormone receptor activity"}
{"concept_id": "C1148781", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III transcription factor activity", "definition": "OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription. [GOC:jl]"}
{"concept_id": "C1148782", "aliases": [], "types": ["T045"], "canonical_name": "transcription antiterminator activity", "definition": "OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed. [ISBN:0198506732]"}
{"concept_id": "C1148783", "aliases": ["transcriptional elongation regulator activity", "transcription elongation regulator activity", "transcription elongation factor activity"], "types": ["T045"], "canonical_name": "transcription elongation regulator activity", "definition": "A molecular function that regulates transcriptional elongation by enabling the transition from transcription initiation to elongation or by altering the elongation properties of the enzyme during the elongation phase of transcription. [GOC:txnOH-2018, PMID:23878398, PMID:28892040]"}
{"concept_id": "C1148785", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I transcription elongation factor activity", "definition": "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation. [GOC:mah]"}
{"concept_id": "C1148786", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription elongation factor activity", "definition": "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation. [GOC:mah]"}
{"concept_id": "C1148787", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III transcription elongation factor activity", "definition": "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation. [GOC:mah]"}
{"concept_id": "C1148789", "aliases": [], "types": ["T045"], "canonical_name": "transcription initiation factor activity", "definition": "OBSOLETE. Plays a role in regulating transcription initiation. [GOC:curators]"}
{"concept_id": "C1148790", "aliases": [], "types": ["T044"], "canonical_name": "antisigma factor binding", "definition": "Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator. [GOC:mlg]"}
{"concept_id": "C1148791", "aliases": ["DNA-dependent RNA polymerase promoter selection factor", "sigma transcription factor", "core DNA-dependent RNA polymerase binding promoter specificity activity"], "types": ["T045"], "definition": "Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. [GOC:txnOH-2018]", "canonical_name": "sigma factor activity"}
{"concept_id": "C1148793", "aliases": ["anti-sigma factor activity"], "types": ["T045"], "canonical_name": "sigma factor antagonist activity", "definition": "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. [GOC:jl, GOC:txnOH, Wikipedia:Anti-sigma_factors]"}
{"concept_id": "C1148794", "aliases": [], "types": ["T045"], "canonical_name": "transcription termination factor activity", "definition": "OBSOLETE. Any activity that brings about termination of transcription. [GOC:mah]"}
{"concept_id": "C1148795", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I transcription termination factor activity", "definition": "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I. [GOC:mah]"}
{"concept_id": "C1148796", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription termination factor activity", "definition": "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II. [GOC:mah]"}
{"concept_id": "C1148797", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III transcription termination factor activity", "definition": "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III. [GOC:mah]"}
{"concept_id": "C1148800", "aliases": [], "types": ["T045"], "canonical_name": "transcription repressor activity", "definition": "OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription. [GOC:mah]"}
{"concept_id": "C1148803", "aliases": [], "types": ["T045"], "canonical_name": "two-component response regulator activity"}
{"concept_id": "C1148804", "aliases": [], "types": ["T045"], "canonical_name": "triplex DNA binding", "definition": "Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination. [PMID:10681538]"}
{"concept_id": "C1148805", "aliases": [], "types": ["T045"], "canonical_name": "unmethylated CpG binding", "definition": "Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters. [GOC:ai, PMID:10688657]"}
{"concept_id": "C1148806", "aliases": [], "types": ["T045"], "definition": "Catalysis of the hydrolysis of ester linkages within nucleic acids. [ISBN:0198547684]", "canonical_name": "nuclease activity"}
{"concept_id": "C1148807", "aliases": [], "types": ["T045"], "definition": "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. [GOC:mah, ISBN:0198547684]", "canonical_name": "endonuclease activity"}
{"concept_id": "C1148808", "aliases": [], "types": ["T045"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [PMID:12713806]", "canonical_name": "endonuclease VIII activity"}
{"concept_id": "C1148809", "aliases": [], "types": ["T045"], "definition": "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. [GOC:mah, ISBN:0198547684]", "canonical_name": "endoribonuclease activity"}
{"concept_id": "C1148810", "aliases": ["endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "3'-endonuclease activity"], "types": ["T045"], "canonical_name": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. [GOC:mah]"}
{"concept_id": "C1148811", "aliases": ["5'-endonuclease activity", "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"], "types": ["T045"], "canonical_name": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. [GOC:mah]"}
{"concept_id": "C1148812", "aliases": [], "types": ["T045"], "canonical_name": "endoribonuclease activity, producing 5'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. [GOC:ai]"}
{"concept_id": "C1148813", "aliases": ["hybrid ribonuclease activity", "hybridase (ribonuclease H)", "RNA*DNA hybrid ribonucleotidohydrolase activity", "hybridase activity", "calf thymus ribonuclease H activity", "hybrid nuclease activity", "RNase H activity", "RNA-DNA hybrid ribonuclease activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. [EC:3.1.26.4]", "canonical_name": "ribonuclease H activity"}
{"concept_id": "C1148814", "aliases": ["RNase H1 activity"], "types": ["T045"], "canonical_name": "ribonuclease H1 activity"}
{"concept_id": "C1148815", "aliases": ["RNase III activity", "ribonuclease III activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. [PMID:11157775, PMID:15242644]", "canonical_name": "ribonuclease 3 activity"}
{"concept_id": "C1148816", "aliases": ["bidentate RNase III activity"], "types": ["T045"], "canonical_name": "bidentate ribonuclease III activity", "definition": "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference. [PMID:15242644]"}
{"concept_id": "C1148817", "aliases": ["tRNA 5' leader endonuclease activity", "RNase P"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. [EC:3.1.26.5]", "canonical_name": "ribonuclease P activity"}
{"concept_id": "C1148818", "aliases": [], "types": ["T045"], "canonical_name": "RNA lariat debranching enzyme activity", "definition": "Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide. [PMID:7519612]"}
{"concept_id": "C1148819", "aliases": ["endoribonuclease activity, producing other than 5'-phosphomonoesters"], "types": ["T045"], "canonical_name": "endoribonuclease activity, producing 3'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. [GOC:ai]"}
{"concept_id": "C1148820", "aliases": ["Enterobacter RNase activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. [EC:4.6.1.21]", "canonical_name": "Enterobacter ribonuclease activity"}
{"concept_id": "C1148821", "aliases": ["ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity", "pancreatic RNase activity", "ribonuclease A activity", "RNase A activity", "RNase I activity", "ceratitis capitata alkaline ribonuclease activity", "ribonuclease I activity", "ribonucleic phosphatase activity", "alkaline ribonuclease activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. [EC:4.6.1.18]", "canonical_name": "pancreatic ribonuclease activity"}
{"concept_id": "C1148822", "aliases": ["tRNA-intron endonuclease activity", "splicing endonuclease activity", "transfer ribonucleate intron endoribonuclease activity", "tRNATRPintron endonuclease activity", "tRNA-splicing endonuclease activity", "transfer splicing endonuclease activity", "tRNA-intron endoribonuclease activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. [EC:3.1.27.9]", "canonical_name": "tRNA splicing endonuclease activity"}
{"concept_id": "C1148824", "aliases": [], "types": ["T045"], "definition": "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. [GOC:mah, ISBN:0198547684]", "canonical_name": "exonuclease activity"}
{"concept_id": "C1148825", "aliases": ["3'-5'-exonuclease activity"], "types": ["T045"], "canonical_name": "3'-5' exonuclease activity", "definition": "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. [GOC:ai]"}
{"concept_id": "C1148826", "aliases": ["3'-5' exoribonuclease activity"], "types": ["T045"], "canonical_name": "3'-5'-exoribonuclease activity", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1148827", "aliases": ["RNase II activity", "RNase II", "ribonuclease II activity", "BN ribonuclease activity", "5'-exoribonuclease activity"], "types": ["T045"], "definition": "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction. [EC:3.1.13.1, ISBN:0198547684]", "canonical_name": "exoribonuclease II activity"}
{"concept_id": "C1148828", "aliases": [], "types": ["T045"], "canonical_name": "5'-3' exonuclease activity", "definition": "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. [GOC:ai]"}
{"concept_id": "C1148829", "aliases": [], "types": ["T045"], "canonical_name": "5'-3' exoribonuclease activity", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1148830", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "viral host shutoff protein"}
{"concept_id": "C1148831", "aliases": [], "types": ["T045"], "canonical_name": "exonuclease IX activity"}
{"concept_id": "C1148832", "aliases": [], "types": ["T045"], "canonical_name": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters. [GOC:mah]"}
{"concept_id": "C1148833", "aliases": ["exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters"], "types": ["T045"], "canonical_name": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. [GOC:mah]"}
{"concept_id": "C1148834", "aliases": [], "types": ["T044"], "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. [GOC:mah, ISBN:0198547684]", "canonical_name": "exoribonuclease activity"}
{"concept_id": "C1148835", "aliases": [], "types": ["T045"], "canonical_name": "exoribonuclease activity, producing 3'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters. [GOC:ai]"}
{"concept_id": "C1148836", "aliases": ["exoribonuclease activity, producing 5' phosphomonoesters"], "types": ["T045"], "canonical_name": "exoribonuclease activity, producing 5'-phosphomonoesters", "definition": "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. [GOC:ai]"}
{"concept_id": "C1148837", "aliases": [], "types": ["T045"], "definition": "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions. [EC:3.1.13.2, ISBN:0198547684]", "canonical_name": "exoribonuclease H activity"}
{"concept_id": "C1148838", "aliases": ["poly(A)-specific RNase activity", "poly(A)-specific ribonuclease activity"], "types": ["T045"], "definition": "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. [EC:3.1.13.4, ISBN:0198547684]", "canonical_name": "3'-exoribonuclease activity"}
{"concept_id": "C1148839", "aliases": ["oligonucleate 5'-nucleotidohydrolase activity", "PDE I activity", "phosphodiesterase I activity", "orthophosphoric diester phosphohydrolase activity", "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity"], "types": ["T045"], "definition": "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. [EC:3.1.4.1]", "canonical_name": "nucleotide pyrophosphatase/phosphodiesterase I activity"}
{"concept_id": "C1148840", "aliases": [], "types": ["T045"], "definition": "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. [GOC:mah, ISBN:0198547684]", "canonical_name": "ribonuclease activity"}
{"concept_id": "C1148841", "aliases": [], "types": ["T045"], "definition": "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. [PMID:10722715, PMID:16854990]", "canonical_name": "ribonuclease E activity"}
{"concept_id": "C1148842", "aliases": [], "types": ["T045"], "canonical_name": "ribonuclease G activity", "definition": "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. [PMID:10722715, PMID:16854990]"}
{"concept_id": "C1148843", "aliases": ["ribonuclease MRP activity"], "types": ["T045"], "definition": "Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA. [PMID:17881380]", "canonical_name": "RNase MRP"}
{"concept_id": "C1148844", "aliases": ["RNase T1", "RNase N2 activity", "binase activity", "guanyl-specific RNase activity", "guanyloribonuclease activity", "RNase F1", "ribonuclease T1 activity", "ribonuclease F1", "ribonuclease guaninenucleotido-2'-transferase (cyclizing)", "RNase T1 activity", "RNase N1 activity"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates. [GOC:curators]", "canonical_name": "ribonuclease N1"}
{"concept_id": "C1148845", "aliases": ["tRNA-specific RNase activity"], "types": ["T045"], "canonical_name": "tRNA-specific ribonuclease activity", "definition": "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. [GOC:mah]"}
{"concept_id": "C1148846", "aliases": [], "types": ["T045"], "definition": "Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]", "canonical_name": "RNA binding"}
{"concept_id": "C1148849", "aliases": [], "types": ["T045"], "canonical_name": "7S RNA binding", "definition": "Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). [GOC:jl, PMID:6181418]"}
{"concept_id": "C1148851", "aliases": ["dsRNA binding"], "types": ["T045"], "canonical_name": "double-stranded RNA binding", "definition": "Binding to double-stranded RNA. [GOC:jl]"}
{"concept_id": "C1148852", "aliases": [], "types": ["T045"], "canonical_name": "double-stranded RNA adenosine deaminase activity", "definition": "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule. [GOC:mah]"}
{"concept_id": "C1148853", "aliases": [], "types": ["T045"], "canonical_name": "mRNA binding", "definition": "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. [GOC:kmv, GOC:pr, SO:0000234]"}
{"concept_id": "C1148854", "aliases": ["IRE binding"], "types": ["T045"], "canonical_name": "iron-responsive element binding", "definition": "Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins. [PMID:3198610, PMID:8710843]"}
{"concept_id": "C1148855", "aliases": ["mRNA 3' UTR binding"], "types": ["T045"], "canonical_name": "mRNA 3'-UTR binding", "definition": "Binding to a 3' untranslated region of an mRNA molecule. [GOC:mah]"}
{"concept_id": "C1148856", "aliases": ["poly(A) binding, within an RNA molecule", "poly-A binding", "polyadenylate binding", "poly(rA) binding"], "types": ["T045"], "canonical_name": "poly(A) binding", "definition": "Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. [GOC:jl]"}
{"concept_id": "C1148857", "aliases": ["pre-mRNA cleavage factor activity"], "types": ["T045"], "canonical_name": "pre-mRNA cleavage required for polyadenylation", "definition": "OBSOLETE. Any activity required for the process of mRNA cleavage. [GOC:mah, PMID:10357856]"}
{"concept_id": "C1148858", "aliases": [], "types": ["T045"], "definition": "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide. [PMID:10357856]", "canonical_name": "cleavage stimulation factor activity"}
{"concept_id": "C1148859", "aliases": ["cleavage and polyadenylylation specificity factor activity"], "types": ["T045"], "canonical_name": "cleavage and polyadenylylation specificity factor activity", "definition": "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions. [PMID:10357856]"}
{"concept_id": "C1148864", "aliases": [], "types": ["T045"], "canonical_name": "poly-pyrimidine tract binding", "definition": "Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule. [GOC:jl]"}
{"concept_id": "C1148865", "aliases": ["U-rich CPE binding", "uridine-rich cytoplasmic polyadenylation element binding"], "types": ["T045"], "canonical_name": "uridine-rich cytoplasmic polyadenylylation element binding", "definition": "Binding to a U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation. [GOC:krc, PMID:7954828]"}
{"concept_id": "C1148866", "aliases": [], "types": ["T045"], "canonical_name": "RNA cap binding", "definition": "Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. [GOC:krc]"}
{"concept_id": "C1148867", "aliases": ["RNA m7G cap binding"], "types": ["T045"], "canonical_name": "RNA 7-methylguanosine cap binding", "definition": "Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. [GOC:krc]"}
{"concept_id": "C1148868", "aliases": [], "types": ["T045"], "canonical_name": "RNA cap 4 binding", "definition": "Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa. [GOC:krc, PMID:10880518, PMID:12121975]"}
{"concept_id": "C1148869", "aliases": ["RNA m2,2,7G cap binding"], "types": ["T045"], "canonical_name": "RNA trimethylguanosine cap binding", "definition": "Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans. [GOC:krc]"}
{"concept_id": "C1148870", "aliases": ["RNA helicase activity"], "types": ["T045"], "definition": "Unwinding of an RNA helix, driven by ATP hydrolysis. [GOC:jl, PMID:19158098]", "canonical_name": "ATP-dependent RNA helicase activity"}
{"concept_id": "C1148872", "aliases": [], "types": ["T045"], "canonical_name": "RNA modification guide activity", "definition": "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148873", "aliases": [], "types": ["T045"], "canonical_name": "RNA 2'-O-ribose methylation guide activity", "definition": "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148874", "aliases": [], "types": ["T045"], "canonical_name": "rRNA 2'-O-ribose methylation guide activity", "definition": "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148875", "aliases": [], "types": ["T045"], "canonical_name": "snRNA 2'-O-ribose methylation guide activity", "definition": "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule. [PMID:11733745]"}
{"concept_id": "C1148876", "aliases": [], "types": ["T045"], "canonical_name": "tRNA 2'-O-ribose methylation guide activity", "definition": "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148877", "aliases": [], "types": ["T045"], "canonical_name": "RNA pseudouridylation guide activity", "definition": "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148878", "aliases": [], "types": ["T045"], "canonical_name": "rRNA pseudouridylation guide activity", "definition": "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148879", "aliases": [], "types": ["T045"], "canonical_name": "snRNA pseudouridylation guide activity", "definition": "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule. [PMID:11733745]"}
{"concept_id": "C1148880", "aliases": [], "types": ["T045"], "canonical_name": "tRNA pseudouridylation guide activity", "definition": "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148881", "aliases": [], "types": ["T045"], "canonical_name": "rRNA modification guide activity", "definition": "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148882", "aliases": [], "types": ["T045"], "canonical_name": "snRNA modification guide activity", "definition": "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148883", "aliases": [], "types": ["T045"], "canonical_name": "tRNA modification guide activity", "definition": "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue. [GOC:mah, PMID:12457565]"}
{"concept_id": "C1148884", "aliases": [], "types": ["T045"], "canonical_name": "rRNA binding", "definition": "Binding to a ribosomal RNA. [GOC:jl]"}
{"concept_id": "C1148885", "aliases": ["pre-rRNA binding"], "types": ["T045"], "canonical_name": "rRNA primary transcript binding", "definition": "Binding to an unprocessed ribosomal RNA transcript. [GOC:jl]"}
{"concept_id": "C1148886", "aliases": ["ssRNA binding"], "types": ["T045"], "canonical_name": "single-stranded RNA binding", "definition": "Binding to single-stranded RNA. [GOC:jl]"}
{"concept_id": "C1148887", "aliases": ["poly(rC) binding"], "types": ["T045"], "canonical_name": "poly(C) RNA binding", "definition": "Binding to a sequence of cytosine residues in an RNA molecule. [GOC:mah]"}
{"concept_id": "C1148888", "aliases": ["poly(U) binding"], "types": ["T045"], "canonical_name": "poly(U) RNA binding", "definition": "Binding to a sequence of uracil residues in an RNA molecule. [GOC:mah]"}
{"concept_id": "C1148889", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA binding", "definition": "Binding to a small nucleolar RNA. [GOC:mah]"}
{"concept_id": "C1148890", "aliases": ["small nuclear RNA binding"], "types": ["T045"], "canonical_name": "snRNA binding", "definition": "Binding to a small nuclear RNA (snRNA). [GOC:mah]"}
{"concept_id": "C1148891", "aliases": [], "types": ["T045"], "canonical_name": "U1 snRNA binding", "definition": "Binding to a U1 small nuclear RNA (U1 snRNA). [GOC:mah]"}
{"concept_id": "C1148892", "aliases": [], "types": ["T045"], "canonical_name": "U11 snRNA binding", "definition": "Binding to a U11 small nuclear RNA (U11 snRNA). [GOC:jl]"}
{"concept_id": "C1148893", "aliases": [], "types": ["T045"], "canonical_name": "U12 snRNA binding", "definition": "Binding to a U12 small nuclear RNA (U12 snRNA). [GOC:jl]"}
{"concept_id": "C1148894", "aliases": [], "types": ["T045"], "canonical_name": "U2 snRNA binding", "definition": "Binding to a U2 small nuclear RNA (U2 snRNA). [GOC:jl]"}
{"concept_id": "C1148895", "aliases": [], "types": ["T045"], "canonical_name": "U4 snRNA binding", "definition": "Binding to a U4 small nuclear RNA (U4 snRNA). [GOC:jl]"}
{"concept_id": "C1148896", "aliases": [], "types": ["T045"], "canonical_name": "U4atac snRNA binding", "definition": "Binding to a U4atac small nuclear RNA (U4atac snRNA). [GOC:jl]"}
{"concept_id": "C1148897", "aliases": [], "types": ["T045"], "canonical_name": "U5 snRNA binding", "definition": "Binding to a U5 small nuclear RNA (U5 snRNA). [GOC:jl]"}
{"concept_id": "C1148898", "aliases": [], "types": ["T045"], "canonical_name": "U6 snRNA binding", "definition": "Binding to a U6 small nuclear RNA (U6 snRNA). [GOC:mah]"}
{"concept_id": "C1148899", "aliases": ["U6 snRNA 3' end binding"], "types": ["T045"], "canonical_name": "U6 snRNA 3'-end binding", "definition": "Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end. [GOC:mah]"}
{"concept_id": "C1148900", "aliases": [], "types": ["T045"], "canonical_name": "U6atac snRNA binding", "definition": "Binding to a U6atac small nuclear RNA (U6atac snRNA). [GOC:jl]"}
{"concept_id": "C1148901", "aliases": [], "types": ["T045"], "canonical_name": "tRNA binding", "definition": "Binding to a transfer RNA. [GOC:ai]"}
{"concept_id": "C1148902", "aliases": [], "types": ["T045"], "canonical_name": "translation factor activity, RNA binding", "definition": "Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. [GOC:ai, GOC:vw]"}
{"concept_id": "C1148903", "aliases": [], "types": ["T045"], "canonical_name": "protein-synthesizing GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs. [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN]"}
{"concept_id": "C1148904", "aliases": [], "types": ["T044"], "canonical_name": "protein-synthesizing GTPase activity, elongation", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.48]"}
{"concept_id": "C1148905", "aliases": [], "types": ["T044"], "canonical_name": "protein-synthesizing GTPase activity, initiation", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.48]"}
{"concept_id": "C1148906", "aliases": [], "types": ["T044"], "canonical_name": "protein-synthesizing GTPase activity, termination", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.48]"}
{"concept_id": "C1148907", "aliases": [], "types": ["T045"], "canonical_name": "translation activator activity", "definition": "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. [GOC:ai]"}
{"concept_id": "C1148908", "aliases": [], "types": ["T045"], "canonical_name": "translation elongation factor activity", "definition": "Functions in chain elongation during polypeptide synthesis at the ribosome. [ISBN:0198506732]"}
{"concept_id": "C1148909", "aliases": [], "types": ["T045"], "canonical_name": "translation initiation factor activity", "definition": "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. [ISBN:0198506732]"}
{"concept_id": "C1148910", "aliases": [], "types": ["T045"], "canonical_name": "translation repressor activity, nucleic acid binding"}
{"concept_id": "C1148911", "aliases": [], "types": ["T045"], "canonical_name": "translation termination factor activity", "definition": "Functions in the termination of translation. [GOC:ma]"}
{"concept_id": "C1148912", "aliases": [], "types": ["T045"], "canonical_name": "translation release factor activity", "definition": "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. [ISBN:0198547684]"}
{"concept_id": "C1148914", "aliases": [], "types": ["T045"], "canonical_name": "translation release factor activity, codon nonspecific", "definition": "A translation release factor that is not specific to particular codons; binds to guanine nucleotides. [ISBN:0198547684]"}
{"concept_id": "C1148915", "aliases": [], "types": ["T045"], "canonical_name": "translation release factor activity, codon specific", "definition": "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. [ISBN:0198547684]"}
{"concept_id": "C1148916", "aliases": [], "types": ["T044"], "canonical_name": "nucleotide binding", "definition": "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1148917", "aliases": [], "types": ["T044"], "canonical_name": "cyclic nucleotide binding", "definition": "Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:ai]"}
{"concept_id": "C1148918", "aliases": ["adenosine 3',5'-cyclophosphate binding", "cyclic AMP binding", "3',5' cAMP binding", "3',5'-cAMP binding"], "types": ["T044"], "canonical_name": "cAMP binding", "definition": "Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). [GOC:ai]"}
{"concept_id": "C1148919", "aliases": ["3',5'-cGMP binding", "3',5' cGMP binding", "cyclic GMP binding"], "types": ["T044"], "canonical_name": "cGMP binding", "definition": "Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). [GOC:ai]"}
{"concept_id": "C1148920", "aliases": [], "types": ["T044"], "canonical_name": "purine nucleotide binding", "definition": "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. [GOC:ai]"}
{"concept_id": "C1148921", "aliases": [], "types": ["T044"], "canonical_name": "adenyl nucleotide binding", "definition": "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate. [ISBN:0198506732]"}
{"concept_id": "C1148922", "aliases": [], "types": ["T044"], "canonical_name": "AMP binding", "definition": "Binding to AMP, adenosine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1148923", "aliases": [], "types": ["T044"], "definition": "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]", "canonical_name": "ATP binding"}
{"concept_id": "C1148924", "aliases": ["(2-5')oligo(A) synthetase activity", "oligo-2',5'-adenylate synthetase activity", "2'-5' oligoadenylate synthetase activity", "2'-5'-oligoadenylate synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA. [ISBN:0198506732]", "canonical_name": "2-5A synthetase activity"}
{"concept_id": "C1148926", "aliases": ["ATP phosphohydrolase activity", "adenosine triphosphatase activity", "ATP hydrolase activity", "ATP hydrolysis activity", "adenosinetriphosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]", "canonical_name": "adenosine 5'-triphosphatase activity"}
{"concept_id": "C1148928", "aliases": ["single-stranded DNA-dependent ATP-dependent DNA helicase activity", "single-stranded DNA-dependent ATPase activity", "ssDNA-dependent ATPase activity", "ssDNA-dependent ATP-dependent DNA helicase activity"], "types": ["T045"], "canonical_name": "single-stranded DNA helicase activity", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. [GOC:jl]"}
{"concept_id": "C1148929", "aliases": ["DNA dependent ATPase activity", "DNA-dependent ATPase activity", "DNA-dependent adenosinetriphosphatase activity", "ATP-dependent activity, acting on DNA", "ATPase, acting on DNA", "ATPase activity, acting on DNA"], "types": ["T044"], "definition": "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. [GOC:pdt]", "canonical_name": "adenosinetriphosphatase (DNA-dependent)"}
{"concept_id": "C1148930", "aliases": ["ATPase, acting on RNA", "ATPase activity, acting on RNA", "ATP-dependent activity, acting on RNA", "RNA-dependent adenosinetriphosphatase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. [GOC:jl]", "canonical_name": "RNA-dependent ATPase activity"}
{"concept_id": "C1148931", "aliases": ["arsenical resistance ATPase activity", "arsenical pump-driving ATPase activity", "arsenite transporting ATPase activity", "arsenite-transporting ATPase activity", "arsenite-transmembrane transporting ATPase activity", "arsenite-translocating ATPase activity", "arsenical resistance efflux pump"], "types": ["T044"], "canonical_name": "ATPase-coupled arsenite transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out). [PMID:10970874, RHEA:11348]"}
{"concept_id": "C1148934", "aliases": ["ATP-dependent beta-glucan transporter activity", "beta-glucan-transporting ATPase activity", "ABC-type beta-glucan transporter"], "types": ["T044"], "canonical_name": "ATPase-coupled beta-glucan transporter activity"}
{"concept_id": "C1148935", "aliases": ["ATPase-coupled capsular-polysaccharide transporter activity", "capsular-polysaccharide-transporting ATPase activity", "ATP phosphohydrolase (capsular-polysaccharide-exporting)", "ATP-dependent capsular-polysaccharide transporter activity"], "types": ["T044"], "canonical_name": "ABC-type capsular-polysaccharide transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out). [EC:7.6.2.12]"}
{"concept_id": "C1148936", "aliases": ["ATP-dependent heme transmembrane transporter activity", "haem-transporting ATPase activity", "heme-transporting ATPase activity", "ATPase-coupled heme transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type heme transporter activity", "definition": "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out). [RHEA:19261]"}
{"concept_id": "C1148937", "aliases": ["lipopolysaccharide-transporting ATPase activity", "LPS-transporting ATPase activity", "ATP-dependent intramembrane lipopolysaccharide transporter activity", "lipopolysaccharide floppase activity (cytosolic to exoplasmic leaftlet)"], "types": ["T044"], "canonical_name": "lipopolysaccharide floppase activity", "definition": "Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [EC:7.5.2.5]"}
{"concept_id": "C1148938", "aliases": ["ATP-dependent peptide transmembrane transporter activity", "peptide-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled peptide transmembrane transporter activity"}
{"concept_id": "C1148939", "aliases": ["ABC-type teichoic-acid transporter", "ATPase-coupled teichoic acid transmembrane transporter activity", "teichoic-acid ABC transporter", "ATP-dependent teichoic acid transmembrane transporter activity", "teichoic-acid-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type teichoic acid transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out). [PMID:7565096]"}
{"concept_id": "C1148942", "aliases": [], "types": ["T044"], "canonical_name": "bile acid porter activity"}
{"concept_id": "C1148943", "aliases": ["ATPase-coupled glutathione S-conjugate transmembrane transporter activity", "MRP1/GS-X pump", "glutathione S-conjugate-exporting ATPase activity", "ABC-type glutathione S-conjugate transporter activity", "GS-X pump"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out). [GOC:jl, PMID:1455517, RHEA:19121]", "canonical_name": "ATP-dependent glutathione S-conjugate export pump"}
{"concept_id": "C1148945", "aliases": [], "types": ["T044"], "canonical_name": "heavy metal-exporting ATPase activity", "definition": "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate. [GOC:ai]"}
{"concept_id": "C1148946", "aliases": ["ATP-dependent cadmium transmembrane transporter activity", "cadmium-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled cadmium transmembrane transporter activity"}
{"concept_id": "C1148947", "aliases": [], "types": ["T044"], "canonical_name": "cobalt porter activity"}
{"concept_id": "C1148948", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "copper-exporting ATPase activity"}
{"concept_id": "C1148949", "aliases": [], "types": ["T044"], "canonical_name": "zinc porter activity"}
{"concept_id": "C1148950", "aliases": ["ATPase-coupled peptide antigen transmembrane transporter activity", "peptide antigen-transporting ATPase activity", "major histocompatibility peptide transporter activity", "ATP-dependent peptide antigen transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type peptide antigen transporter activity", "definition": "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate. [TC:3.A.1.209.1]"}
{"concept_id": "C1148951", "aliases": [], "types": ["T044"], "canonical_name": "mating pheromone exporter", "definition": "OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating. [GOC:jl]"}
{"concept_id": "C1148952", "aliases": [], "types": ["T044"], "canonical_name": "peroxisomal fatty acyl transporter", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1148955", "aliases": ["thiamin pyrophosphate transporting ATPase activity", "thiamine pyrophosphate-transporting ATPase activity"], "types": ["T044"], "canonical_name": "TPP transporting ATPase activity"}
{"concept_id": "C1148956", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane conductance regulator activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1148957", "aliases": ["CFTR", "intracellularly ATP-gated chloride channel activity"], "types": ["T044"], "definition": "Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. [PMID:24727426, PMID:9922375]", "canonical_name": "channel-conductance-controlling ATPase activity"}
{"concept_id": "C1148959", "aliases": ["ABC-type xenobiotic transporter activity", "ATPase-coupled xenobiotic transmembrane transporter activity", "ATP-dependent xenobiotic transmembrane transporter activity", "xenobiotic transmembrane transporting ATPase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). [EC:7.6.2.2]", "canonical_name": "ATP phosphohydrolase (xenobiotic-exporting)"}
{"concept_id": "C1148961", "aliases": ["ATP-dependent amino acid transmembrane transporter activity", "ATPase-coupled amino acid transmembrane transporter activity", "amino acid-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type amino acid transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out). [GOC:ai, GOC:mah]"}
{"concept_id": "C1148962", "aliases": ["nonpolar-amino-acid-transporting ATPase activity", "nonpolar amino acid-transporting ATPase activity", "nonpolar-amino acid-transporting ATPase activity", "ATP-dependent nonpolar-amino acid transporter activity", "nonpolar-amino acid ABC transporter"], "types": ["T044"], "canonical_name": "ATPase-coupled nonpolar-amino acid transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in). [EC:7.4.2.2]"}
{"concept_id": "C1148963", "aliases": ["leucine/isoleucine/valine porter activity"], "types": ["T044"], "canonical_name": "leucine/isoleucine/valine porter activity", "definition": "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in). [EC:3.6.3.22, TC:3.A.1.4.1]"}
{"concept_id": "C1148964", "aliases": ["polar-amino acid-importing ATPase activity", "polar amino acid-importing ATPase activity", "ATP-dependent polar amino acid-transporter activity", "polar-amino acid-transporting ATPase activity", "polar-amino-acid-transporting ATPase activity", "polar amino acid uptake transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled polar amino acid-transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). [EC:7.4.2.1]"}
{"concept_id": "C1148965", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled L-arginine transmembrane transporter activity"}
{"concept_id": "C1148966", "aliases": ["cystine/diaminopimelate porter activity"], "types": ["T044"], "canonical_name": "cystine/diaminopimelate porter activity", "definition": "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). [EC:3.6.3.21, TC:3.A.1.3.10]"}
{"concept_id": "C1148967", "aliases": ["glutamate/aspartate porter activity"], "types": ["T044"], "canonical_name": "glutamate/aspartate porter activity", "definition": "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). [EC:3.6.3.21, TC:3.A.1.3.4]"}
{"concept_id": "C1148968", "aliases": [], "types": ["T044"], "canonical_name": "glutamine-importing ATPase activity"}
{"concept_id": "C1148969", "aliases": ["histidine/arginine/lysine/ornithine porter activity"], "types": ["T044"], "canonical_name": "histidine/arginine/lysine/ornithine porter activity", "definition": "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). [EC:3.6.3.21, TC:3.A.1.3.1]"}
{"concept_id": "C1148970", "aliases": ["carbohydrate-importing ABC transporter activity", "carbohydrate-importing ATPase activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in). [GOC:ai]", "canonical_name": "carbohydrate uptake transporter activity"}
{"concept_id": "C1148972", "aliases": [], "types": ["T044"], "canonical_name": "D-allose-importing ATPase activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in). [GOC:curators]"}
{"concept_id": "C1148973", "aliases": ["galactose/glucose (methylgalactoside) porter activity"], "types": ["T044"], "canonical_name": "galactose/glucose (methylgalactoside) porter activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1148974", "aliases": [], "types": ["T044"], "canonical_name": "glycerol phosphate-importing ATPase activity"}
{"concept_id": "C1148976", "aliases": [], "types": ["T044"], "canonical_name": "monosaccharide-importing ATPase activity"}
{"concept_id": "C1148979", "aliases": ["cation-transporting ATPase activity", "ATP-dependent cation transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled cation transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). [GOC:ai]"}
{"concept_id": "C1148980", "aliases": [], "types": ["T044"], "canonical_name": "plasma membrane cation-transporting ATPase", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1148981", "aliases": ["ATPase-coupled ferric-enterobactin transmembrane transporter activity", "ferric-enterobactin ABC transporter", "ATP-dependent ferric-enterobactin transmembrane transporter activity", "ferric-enterobactin-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type ferric-enterobactin transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in). [RHEA:58492]"}
{"concept_id": "C1148982", "aliases": ["ATP-dependent ferric-hydroxamate transmembrane transporter activity", "ATPase-coupled ferric-hydroxamate transmembrane transporter activity", "ferric-hydroxamate-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type ferric hydroxamate transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in). [PMID:1551849]"}
{"concept_id": "C1148983", "aliases": ["ferric transporting ATPase activity", "ferric ABC transporter", "ATPase-coupled ferric iron transmembrane transporter activity", "ABC-type Fe3+ transporter", "Fe3+-transporting ATPase activity", "ferric-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type ferric iron transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in). [RHEA:12332]"}
{"concept_id": "C1148985", "aliases": ["glycerol-3-phosphate-transporting ATPase", "ABC-type glycerol 3-phosphate transporter", "ATPase-coupled glycerol-3-phosphate transmembrane transporter activity", "glycerol-3-phosphate ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type glycerol-3-phosphate transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in). [RHEA:21668]"}
{"concept_id": "C1148986", "aliases": ["guanine-transporting ATPase activity", "ATP-dependent guanine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled guanine transmembrane transporter activity"}
{"concept_id": "C1148987", "aliases": ["ABC-type Mn(2+) transporter", "manganese-transporting ATPase activity", "ATP-dependent manganese transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type manganese transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in). [RHEA:17365]"}
{"concept_id": "C1148988", "aliases": ["molybdate-transporting ATPase activity", "molybdate transporting ATPase activity", "molybdate transmembrane-transporting ATPase activity", "molybdate porter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled molybdate transmembrane transporter activity"}
{"concept_id": "C1148989", "aliases": ["nickel transporting ATPase activity", "ATP-dependent nickel transmembrane transporter activity", "nickel ABC transporter activity", "ATPase-coupled nickel transmembrane transporter activity", "nickel porter activity", "nickel ABC transporter", "nickel-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type nickel transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in). [RHEA:15557]"}
{"concept_id": "C1148990", "aliases": ["nitrate-transporting ATPase activity", "nitrate transmembrane-transporting ATPase activity", "nitrate transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled nitrate transmembrane transporter activity"}
{"concept_id": "C1148991", "aliases": ["ABC-type oligopeptide transporter", "ATPase-coupled oligopeptide transmembrane transporter activity", "oligopeptide-transporting ATPase activity", "ATP-dependent oligopeptide transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type oligopeptide transporter activity", "definition": "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in). [RHEA:37271]"}
{"concept_id": "C1148992", "aliases": ["ABC-type oligosaccharide transporter", "oligosaccharide-transporting ATPase activity", "ATP-dependent oligosaccharide transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled oligosaccharide transmembrane transporter activity"}
{"concept_id": "C1148993", "aliases": ["ABC-type maltose transporter", "maltose ABC transporter", "maltose-transporting ATPase activity", "ATP-dependent maltose transmembrane transporter activity", "ATPase-coupled maltose transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type maltose transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in). [RHEA:22132]"}
{"concept_id": "C1148994", "aliases": ["phosphate transporting ATPase activity", "phosphate porter activity", "phosphate-transporting ATPase activity", "ATP phosphohydrolase (phosphate-importing)", "phosphate ion transmembrane-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled phosphate ion transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in). [EC:7.3.2.1]"}
{"concept_id": "C1148996", "aliases": ["ATP-dependent polyamine transmembrane transporter activity", "polyamine-transporting ATPase activity", "polyamine porter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled polyamine transmembrane transporter activity"}
{"concept_id": "C1148997", "aliases": [], "types": ["T044"], "canonical_name": "putrescine-importing ATPase activity"}
{"concept_id": "C1148999", "aliases": ["quaternary-amine-transporting ATPase activity", "ATP-dependent quaternary-ammonium compound transmembrane transporting activity", "quaternary amine uptake transporter activity", "quaternary-ammonium-compound-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled quaternary ammonium compound transmembrane transporting activity"}
{"concept_id": "C1149000", "aliases": ["glycine betaine/proline porter activity"], "types": ["T044"], "canonical_name": "glycine betaine/proline porter activity", "definition": "OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in). [EC:3.6.3.32, TC:3.A.1.12.1]"}
{"concept_id": "C1149001", "aliases": ["sulfate-transporting ATPase activity", "sulfate transmembrane-transporting ATPase activity", "sulfate/thiosulfate porter activity", "sulphate transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled sulfate transmembrane transporter activity"}
{"concept_id": "C1149002", "aliases": ["taurine-transporting ATPase activity", "ATP-dependent taurine transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled taurine transporter activity"}
{"concept_id": "C1149003", "aliases": ["ATP-dependent vitamin B12 transmembrane transporter activity", "vitamin B12 ABC transporter activity", "ATPase-coupled cobalamin transmembrane transporter activity", "cobalamin ABC transporter", "cobalamin-transporting ATPase activity", "ATP-dependent cobalamin transmembrane transporter activity", "ATPase-coupled vitamin B12 transmembrane transporter activity", "vitamin B12-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type vitamin B12 transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin. [GOC:pz, RHEA:17873]"}
{"concept_id": "C1149004", "aliases": [], "types": ["T045"], "canonical_name": "DNA translocase activity", "definition": "Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis. [GOC:mah, PMID:16428451, PMID:17631491]"}
{"concept_id": "C1149005", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen-/sodium-translocating ATPase activity", "definition": "OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out). [TC:3.A.2.-.-]"}
{"concept_id": "C1149011", "aliases": ["sodium-translocating F-type ATPase activity", "sodium-transporting two-sector ATPase activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism. [RHEA:58158]", "canonical_name": "sodium-transporting ATP synthase activity, rotational mechanism"}
{"concept_id": "C1149012", "aliases": [], "types": ["T044"], "canonical_name": "sodium-translocating V-type ATPase activity", "definition": "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria. [TC:3.A.2.2.2]"}
{"concept_id": "C1149013", "aliases": ["P-type ATPase activity", "ion transmembrane transporter activity, phosphorylative mechanism", "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"], "types": ["T044"], "canonical_name": "P-type ion transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. [PMID:10322420, PMID:10600683]"}
{"concept_id": "C1149014", "aliases": ["cadmium transmembrane transporter activity, phosphorylative mechanism", "Cd(2+)-exporting ATPase activity", "cadmium-translocating P-type ATPase activity", "Cd2+-exporting ATPase activity", "cadmium exporting ATPase activity", "cadmium-exporting ATPase activity"], "types": ["T044"], "canonical_name": "P-type cadmium transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) -> ADP + phosphate + Cd2+(out). [PMID:17326661]"}
{"concept_id": "C1149015", "aliases": ["P-type calcium transporter activity", "calcium-transporting ATPase activity", "Ca(2+)-transporting ATPase activity", "calcium transporting ATPase activity", "Ca2+-transporting ATPase activity", "ATP-dependent calcium transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out). [RHEA:18105]", "canonical_name": "calcium transmembrane transporter activity, phosphorylative mechanism"}
{"concept_id": "C1149018", "aliases": ["H(+)/K(+)-ATPase activity", "H+-K+-ATPase activity", "H(+)/K(+)-exchanging ATPase activity", "ATP phosphohydrolase (H+/K+-exchanging)", "hydrogen:potassium exchanging ATPase activity", "potassium:proton exchanging ATPase activity", "H+/K+-exchanging ATPase activity", "H+/K+-ATPase activity", "hydrogen/potassium-exchanging ATPase activity", "hydrogen:potassium-exchanging ATPase activity", "P-type potassium:proton transporter activity", "(K+ + H+)-ATPase activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). [RHEA:22044]", "canonical_name": "H,K-ATPase activity"}
{"concept_id": "C1149019", "aliases": ["Mg2+-importing ATPase activity", "Mg(2+)-importing ATPase activity", "ATP phosphohydrolase (Mg2+-importing)", "magnesium transmembrane transporter activity, phosphorylative mechanism", "magnesium importing ATPase activity"], "types": ["T044"], "canonical_name": "P-type magnesium transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) -> ADP + phosphate + Mg2+(in). [RHEA:10260]"}
{"concept_id": "C1149020", "aliases": ["potassium transporting ATPase activity", "ATP-dependent potassium transmembrane transporter activity", "potassium-transporting ATPase activity", "potassium-uptake-ATPase activity", "K(+)-importing ATPase activity", "K+-transporting ATPase activity", "potassium transmembrane transporter activity, phosphorylative mechanism", "K+-importing ATPase activity", "ATP phosphohydrolase (K+-importing)", "K(+)-transporting ATPase activity"], "types": ["T044"], "canonical_name": "P-type potassium transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). [RHEA:16777]"}
{"concept_id": "C1149022", "aliases": ["silver transmembrane transporter activity, phosphorylative mechanism", "Ag+-exporting ATPase activity", "silver-exporting ATPase activity", "ATP phosphohydrolase (Ag+-exporting)", "silver exporting ATPase activity"], "types": ["T044"], "canonical_name": "P-type silver transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) -> ADP + phosphate + Ag+(out). [RHEA:14733]"}
{"concept_id": "C1149024", "aliases": ["Na+/K+-exchanging ATPase activity", "P-type sodium:potassium-exchanging transporter activity", "sodium:potassium-exchanging ATPase activity", "sodium:potassium exchanging ATPase activity", "Na+,K+-ATPase activity", "sodium/potassium-transporting ATPase activity", "sodium/potassium-exchanging ATPase activity", "P-type sodium:potassium-exchanging ATPase activity", "Na(+)/K(+)-ATPase activity", "Na(+)/K(+)-exchanging ATPase activity", "Na+/K+-ATPase activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). [EC:7.2.2.13]", "canonical_name": "Na,K-activated ATPase activity"}
{"concept_id": "C1149025", "aliases": ["zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity"], "types": ["T044"], "canonical_name": "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity", "definition": "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+. [TC:3.A.3.6.2]"}
{"concept_id": "C1149026", "aliases": ["Zn(2+)-exporting ATPase activity", "zinc-translocating P-type ATPase activity", "P1B-type ATPase activity", "zinc exporting ATPase activity", "zinc-exporting ATPase activity", "ATP phosphohydrolase (Zn2+-exporting)", "Zn2+-exporting ATPase activity", "zinc transmembrane transporter activity, phosphorylative mechanism"], "types": ["T044"], "canonical_name": "P-type zinc transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) -> ADP + phosphate + Zn2+(out). [RHEA:20621]"}
{"concept_id": "C1149027", "aliases": ["protein ABC transporter", "ABC-type protein transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type protein transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in). [GOC:jl]"}
{"concept_id": "C1149028", "aliases": ["ATPase-coupled chloroplast protein transporter activity", "AAA chloroplast protein-transporting ATPase"], "types": ["T044"], "canonical_name": "chloroplast protein-transporting ATPase activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma. [EC:7.4.2.4]"}
{"concept_id": "C1149029", "aliases": ["ATPase-coupled mitochondrial protein transporter activity"], "types": ["T044"], "canonical_name": "mitochondrial protein-transporting ATPase activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex. [EC:7.4.2.3]"}
{"concept_id": "C1149030", "aliases": [], "types": ["T044"], "canonical_name": "pilin/fimbrilin exporter activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149031", "aliases": ["ATPase-coupled protein transporter activity"], "types": ["T044"], "canonical_name": "protein-exporting ATPase activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins. [PMID:30346996]"}
{"concept_id": "C1149032", "aliases": [], "types": ["T044"], "canonical_name": "guanyl nucleotide binding", "definition": "Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate. [ISBN:0198506732]"}
{"concept_id": "C1149033", "aliases": [], "types": ["T044"], "canonical_name": "GDP binding", "definition": "Binding to GDP, guanosine 5'-diphosphate. [GOC:ai]"}
{"concept_id": "C1149034", "aliases": [], "types": ["T044"], "canonical_name": "GMP binding", "definition": "Binding to GMP, guanosine monophosphate. [GOC:ai]"}
{"concept_id": "C1149035", "aliases": [], "types": ["T044"], "definition": "Binding to GTP, guanosine triphosphate. [GOC:ai]", "canonical_name": "GTP binding"}
{"concept_id": "C1149036", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: GTP + H2O = GDP + phosphate. [ISBN:0198547684, PMID:26832457, PMID:27218782]", "canonical_name": "GTPase activity"}
{"concept_id": "C1149037", "aliases": [], "types": ["T044"], "canonical_name": "dynamin GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles. [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN]"}
{"concept_id": "C1149038", "aliases": ["heterotrimeric G-protein GTPase activity"], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase activity"}
{"concept_id": "C1149039", "aliases": [], "types": ["T044"], "canonical_name": "signal-recognition-particle GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis. [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN]"}
{"concept_id": "C1149040", "aliases": ["small monomeric GTPase activity"], "types": ["T044"], "canonical_name": "small monomeric GTPase activity"}
{"concept_id": "C1149041", "aliases": [], "types": ["T044"], "canonical_name": "ARF small monomeric GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.47]"}
{"concept_id": "C1149042", "aliases": [], "types": ["T044"], "canonical_name": "Rab small monomeric GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.47]"}
{"concept_id": "C1149043", "aliases": [], "types": ["T044"], "canonical_name": "Ran small monomeric GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.47]"}
{"concept_id": "C1149044", "aliases": [], "types": ["T044"], "canonical_name": "Ras small monomeric GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.47]"}
{"concept_id": "C1149045", "aliases": [], "types": ["T044"], "canonical_name": "RHEB small monomeric GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.47, PMID:12893813]"}
{"concept_id": "C1149046", "aliases": [], "types": ["T044"], "canonical_name": "Rho small monomeric GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. [EC:3.6.1.47, GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1149047", "aliases": [], "types": ["T044"], "canonical_name": "Sar small monomeric GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. [EC:3.6.1.47]"}
{"concept_id": "C1149048", "aliases": [], "types": ["T044"], "canonical_name": "tubulin GTPase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others. [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN]"}
{"concept_id": "C1149049", "aliases": ["GEF", "guanyl-nucleotide release factor activity", "Rho guanine nucleotide exchange factor", "GDP-dissociation stimulator activity", "GDS", "GNRP", "guanyl-nucleotide releasing factor", "guanyl-nucleotide exchange factor activity"], "types": ["T044"], "definition": "Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]", "canonical_name": "RhoGEF"}
{"concept_id": "C1149059", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine nucleotide binding", "definition": "Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate. [GOC:ai]"}
{"concept_id": "C1149060", "aliases": [], "types": ["T044"], "canonical_name": "odorant binding", "definition": "Binding to an odorant, any substance capable of stimulating the sense of smell. [GOC:jl, ISBN:0721662544]"}
{"concept_id": "C1149061", "aliases": [], "types": ["T044"], "canonical_name": "pheromone binding", "definition": "Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. [GOC:ai]"}
{"concept_id": "C1149062", "aliases": [], "types": ["T044"], "definition": "Binding to oxygen (O2). [GOC:jl]", "canonical_name": "oxygen binding"}
{"concept_id": "C1149063", "aliases": ["cytochrome P450", "cytochrome p450 activity"], "types": ["T044"], "definition": "OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer. [ISBN:0198547684, PMID:1655423]", "canonical_name": "cytochrome P450 activity"}
{"concept_id": "C1149064", "aliases": ["25-hydroxyvitamin D3 24-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol. [ISBN:0471331309]", "canonical_name": "25-hydroxycholecalciferol-24-hydroxylase activity"}
{"concept_id": "C1149065", "aliases": [], "types": ["T044"], "canonical_name": "arachidonic acid monooxygenase activity", "definition": "Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. [GOC:mah]"}
{"concept_id": "C1149066", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2C38"}
{"concept_id": "C1149067", "aliases": [], "types": ["T044"], "canonical_name": "arachidonic acid 14,15-epoxygenase activity", "definition": "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, RHEA:51472]"}
{"concept_id": "C1149068", "aliases": [], "types": ["T044"], "canonical_name": "arachidonic acid epoxygenase activity", "definition": "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, PMID:18952572]"}
{"concept_id": "C1149069", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. [GOC:cb]", "canonical_name": "aromatase activity"}
{"concept_id": "C1149070", "aliases": ["25-hydroxyvitamin D-1 alpha hydroxylase activity", "25-OHD-1 alpha-hydroxylase activity", "25-hydroxy vitamin D3 1-alpha-hydroxylase activity", "25-hydroxy D3-1alpha-hydroxylase activity", "25-hydroxycholecalciferol 1-monooxygenase activity", "calcidiol 1-monooxygenase activity", "25-hydroxyvitamin D3 1alpha-hydroxylase activity", "25-hydroxycholecalciferol-1-hydroxylase activity", "25-hydroxycholecalciferol 1-hydroxylase activity", "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+). [EC:1.14.15.18, RHEA:20573]", "canonical_name": "25-hydroxycholecalciferol 1alpha-hydroxylase activity"}
{"concept_id": "C1149071", "aliases": ["cholesterol 7-alpha-monooxygenase activity", "cholesterol 7-alpha-hydroxylase activity", "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)", "cholesterol 7alpha-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. [EC:1.14.14.23]", "canonical_name": "cholesterol 7alpha-monooxygenase activity"}
{"concept_id": "C1149072", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. [Reactome:163103]", "canonical_name": "coumarin 7-hydroxylase activity"}
{"concept_id": "C1149073", "aliases": ["(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity", "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)", "dopamine-B-hydroxylase activity", "dopamine beta-hydroxylase activity", "dopa beta-hydroxylase activity", "dopamine beta-monooxygenase activity", "oxygenase, dopamine beta-mono-", "4-(2-aminoethyl)pyrocatechol beta-oxidase activity", "dopamine hydroxylase activity", "dopamine b-hydroxylase activity", "3,4-dihydroxyphenethylamine beta-oxidase activity", "dopamine beta-oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O. [EC:1.14.17.1, RHEA:19117]", "canonical_name": "phenylamine beta-hydroxylase activity"}
{"concept_id": "C1149076", "aliases": [], "types": ["T044"], "definition": "Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide. [PMID:1742282, PMID:1981702]", "canonical_name": "naphthalene hydroxylase activity"}
{"concept_id": "C1149077", "aliases": [], "types": ["T044"], "canonical_name": "olfactory-specific steroid hydroxylase activity"}
{"concept_id": "C1149078", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O. [PMID:10882791]", "canonical_name": "oxysterol 7-alpha-hydroxylase activity"}
{"concept_id": "C1149079", "aliases": [], "types": ["T044"], "canonical_name": "p-coumarate 3-hydroxylase activity", "definition": "Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+. [PMID:11429408, PMID:11891223]"}
{"concept_id": "C1149081", "aliases": ["prostacycline synthetase activity", "prostagladin I2 synthetase activity", "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity", "PGI(2) synthase activity", "PGI(2) synthetase activity", "PGI2 synthase activity", "prostaglandin-I synthase activity", "prostacyclin synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2). [EC:5.3.99.4, RHEA:23580]", "canonical_name": "PGI2 synthetase activity"}
{"concept_id": "C1149082", "aliases": [], "types": ["T044"], "definition": "Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. [PMID:19519282, PMID:9250660]", "canonical_name": "retinoic acid 4-hydroxylase activity"}
{"concept_id": "C1149083", "aliases": ["steroid 11beta-monooxygenase activity", "steroid 11beta-hydroxylase activity", "steroid 11-beta/18-hydroxylase activity", "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)", "oxygenase, steroid 11beta -mono-", "steroid 11beta/18-hydroxylase activity", "steroid 11-beta-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. [EC:1.14.15.4]", "canonical_name": "steroid 11-beta-hydroxylase activity"}
{"concept_id": "C1149084", "aliases": ["steroid 17-alpha-monooxygenase activity", "steroid 17-alpha-hydroxylase-C17-20 lyase activity", "steroid 17alphahydroxylase/17,20 lyase activity", "17alpha-hydroxylase-C17,20 lyase activity", "steroid 17-alpha-hydroxylase/17,20 lyase activity", "steroid 17-alpha-hydroxylase activity", "steroid 17alpha-hydroxylase activity", "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. [EC:1.14.14.19]", "canonical_name": "steroid 17alpha-monooxygenase activity"}
{"concept_id": "C1149085", "aliases": ["steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)", "steroid 21-monooxygenase activity", "steroid 21-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O. [RHEA:65612]", "canonical_name": "21-hydroxylase activity"}
{"concept_id": "C1149086", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2A12"}
{"concept_id": "C1149087", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O. [GOC:mah]", "canonical_name": "sterol 12-alpha-hydroxylase activity"}
{"concept_id": "C1149088", "aliases": [], "types": ["T044"], "canonical_name": "testosterone 15-alpha-hydroxylase activity", "definition": "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O. [GOC:ai]"}
{"concept_id": "C1149089", "aliases": ["cytochrome P450 CYP2B10", "cytochrome P450 CYP2D10", "cytochrome P450 CYP2D11", "cytochrome P450 CYP2B9"], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2D9"}
{"concept_id": "C1149090", "aliases": ["(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity", "thromboxane synthase activity", "thromboxane synthetase activity", "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). [EC:5.3.99.5, RHEA:17137]", "canonical_name": "thromboxane-A synthase activity"}
{"concept_id": "C1149091", "aliases": [], "types": ["T044"], "canonical_name": "oxygen sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). [GOC:mah]"}
{"concept_id": "C1149092", "aliases": [], "types": ["T044"], "canonical_name": "oxygen-carrying"}
{"concept_id": "C1149093", "aliases": ["oxygen carrier activity"], "types": ["T044"], "definition": "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins. [GOC:ai, ISBN:0198506732]", "canonical_name": "globin"}
{"concept_id": "C1149094", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans. [GOC:ai, ISBN:0198506732]", "canonical_name": "hemerythrin"}
{"concept_id": "C1149095", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods. [GOC:ai, ISBN:0198506732]", "canonical_name": "hemocyanin"}
{"concept_id": "C1149096", "aliases": [], "types": ["T044"], "canonical_name": "penicillin binding", "definition": "Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:ai]"}
{"concept_id": "C1149098", "aliases": [], "types": ["T044"], "canonical_name": "peptide binding", "definition": "Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl]"}
{"concept_id": "C1149099", "aliases": [], "types": ["T044"], "definition": "Combining with an extracellular or intracellular peptide to initiate a change in cell activity. [GOC:jl]", "canonical_name": "peptide receptor activity"}
{"concept_id": "C1149100", "aliases": ["peptide receptor activity, G-protein coupled", "peptide receptor activity, G protein coupled", "G protein coupled peptide receptor activity", "G-protein coupled peptide receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled peptide receptor activity", "definition": "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb]"}
{"concept_id": "C1149101", "aliases": [], "types": ["T044"], "definition": "Combining with adrenomedullin to initiate a change in cell activity. [GOC:ai]", "canonical_name": "adrenomedullin receptor activity"}
{"concept_id": "C1149102", "aliases": [], "types": ["T044"], "definition": "Combining with allatostatin to initiate a change in cell activity. [GOC:ai]", "canonical_name": "allatostatin receptor activity"}
{"concept_id": "C1149103", "aliases": [], "types": ["T044"], "canonical_name": "anaphylatoxin receptor activity"}
{"concept_id": "C1149104", "aliases": [], "types": ["T044"], "canonical_name": "C3a anaphylatoxin receptor activity"}
{"concept_id": "C1149105", "aliases": [], "types": ["T044"], "canonical_name": "C5a anaphylatoxin receptor activity"}
{"concept_id": "C1149106", "aliases": [], "types": ["T044"], "definition": "Combining with angiotensin to initiate a change in cell activity. [GOC:ai]", "canonical_name": "angiotensin receptor activity"}
{"concept_id": "C1149107", "aliases": ["PLC-activating angiotensin receptor activity"], "types": ["T044"], "canonical_name": "angiotensin type I receptor activity", "definition": "An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. [GOC:mah, PMID:10977869]"}
{"concept_id": "C1149108", "aliases": [], "types": ["T044"], "canonical_name": "angiotensin type II receptor activity", "definition": "An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. [GOC:mah, PMID:10977869]"}
{"concept_id": "C1149109", "aliases": [], "types": ["T044"], "definition": "Combining with bombesin to initiate a change in cell activity. [GOC:ai]", "canonical_name": "bombesin receptor activity"}
{"concept_id": "C1149110", "aliases": [], "types": ["T044"], "definition": "Combining with bradykinin to initiate a change in cell activity. [GOC:ai]", "canonical_name": "bradykinin receptor activity"}
{"concept_id": "C1149112", "aliases": ["cholecystokinin receptor activity"], "types": ["T044"], "definition": "Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. [GOC:signaling, PMID:9835394]", "canonical_name": "CCK receptor activity"}
{"concept_id": "C1149113", "aliases": ["cholecystokinin-B receptor activity"], "types": ["T044"], "definition": "Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. [GOC:ai, GOC:signaling]", "canonical_name": "gastrin receptor activity"}
{"concept_id": "C1149114", "aliases": [], "types": ["T044"], "definition": "Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph, GOC:signaling, IUPHAR_GPCR:1283, IUPHAR_RECEPTOR:2263, IUPHAR_RECEPTOR:2265]", "canonical_name": "endothelin receptor activity"}
{"concept_id": "C1149115", "aliases": [], "types": ["T044"], "canonical_name": "endothelin-A receptor activity"}
{"concept_id": "C1149116", "aliases": [], "types": ["T044"], "canonical_name": "endothelin-B receptor activity"}
{"concept_id": "C1149117", "aliases": ["G-protein chemoattractant receptor activity", "G protein chemoattractant receptor activity", "G-protein coupled chemoattractant receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled chemoattractant receptor activity", "definition": "Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah]"}
{"concept_id": "C1149119", "aliases": [], "types": ["T044"], "definition": "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, GOC:signaling, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823, Wikipedia:Chemokine]", "canonical_name": "chemokine receptor activity"}
{"concept_id": "C1149120", "aliases": [], "types": ["T044"], "canonical_name": "C-C chemokine receptor activity", "definition": "Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:signaling, PMID:8662823]"}
{"concept_id": "C1149121", "aliases": [], "types": ["T044"], "canonical_name": "C-X-C chemokine receptor activity", "definition": "Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:signaling, PMID:8662823]"}
{"concept_id": "C1149122", "aliases": ["IL-8 receptor activity", "IL-8R"], "types": ["T044"], "canonical_name": "interleukin-8 receptor activity", "definition": "Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]"}
{"concept_id": "C1149123", "aliases": [], "types": ["T044"], "canonical_name": "C-X3-C chemokine receptor activity", "definition": "Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif. [GOC:dph, GOC:signaling]"}
{"concept_id": "C1149124", "aliases": [], "types": ["T044"], "definition": "Combining with galanin to initiate a change in cell activity. [GOC:ai]", "canonical_name": "galanin receptor activity"}
{"concept_id": "C1149126", "aliases": [], "types": ["T044"], "definition": "Combining with melanocortin to initiate a change in cell activity. [GOC:ai]", "canonical_name": "melanocortin receptor activity"}
{"concept_id": "C1149127", "aliases": ["adrenocorticotropic hormone receptor activity", "adrenocorticotropin receptor activity", "ACTH receptor activity"], "types": ["T044"], "canonical_name": "corticotropin receptor activity", "definition": "Combining with corticotropin to initiate a change in cell activity. [GOC:ai]"}
{"concept_id": "C1149128", "aliases": [], "types": ["T044"], "definition": "Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC). [GOC:ai, GOC:bf, Wikipedia:Beta-endorphin]", "canonical_name": "beta-endorphin receptor activity"}
{"concept_id": "C1149129", "aliases": ["MSHR activity"], "types": ["T044"], "canonical_name": "MSH receptor activity"}
{"concept_id": "C1149130", "aliases": ["Fmet-leu-phe receptor"], "types": ["T044"], "definition": "Combining with an N-formyl peptide to initiate a change in cell activity. [GOC:ai]", "canonical_name": "N-formyl peptide receptor activity"}
{"concept_id": "C1149131", "aliases": ["NMUR activity"], "types": ["T044"], "definition": "Combining with neuromedin U to initiate a change in cell activity. [GOC:ai]", "canonical_name": "neuromedin U receptor activity"}
{"concept_id": "C1149132", "aliases": [], "types": ["T044"], "definition": "Combining with a neuropeptide to initiate a change in cell activity. [GOC:ai]", "canonical_name": "neuropeptide receptor activity"}
{"concept_id": "C1149133", "aliases": ["NPF receptor activity"], "types": ["T044"], "definition": "Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa. [GOC:bf, GOC:ma, PMID:21440021]", "canonical_name": "neuropeptide F receptor activity"}
{"concept_id": "C1149134", "aliases": [], "types": ["T044"], "definition": "Combining with neuropeptide Y to initiate a change in cell activity. [PMID:9315606]", "canonical_name": "neuropeptide Y receptor activity"}
{"concept_id": "C1149135", "aliases": [], "types": ["T044"], "definition": "Combining with pancreatic polypeptide PP to initiate a change in cell activity. [PMID:9315606]", "canonical_name": "pancreatic polypeptide receptor activity"}
{"concept_id": "C1149136", "aliases": [], "types": ["T044"], "definition": "Combining with gut peptide YY to initiate a change in cell activity. [PMID:9315606]", "canonical_name": "peptide YY receptor activity"}
{"concept_id": "C1149137", "aliases": [], "types": ["T044"], "definition": "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein. [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin]", "canonical_name": "tachykinin receptor activity"}
{"concept_id": "C1149138", "aliases": ["neurokinin B receptor activity"], "types": ["T044"], "definition": "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity. [GOC:mah, ISBN:0198506732]", "canonical_name": "neuromedin K receptor activity"}
{"concept_id": "C1149139", "aliases": ["substance K receptor activity", "neuromedin L receptor activity"], "types": ["T044"], "definition": "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity. [GOC:mah, ISBN:0198506732]", "canonical_name": "neurokinin A receptor activity"}
{"concept_id": "C1149140", "aliases": [], "types": ["T044"], "definition": "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. [GOC:mah, ISBN:0198506732]", "canonical_name": "substance P receptor activity"}
{"concept_id": "C1149141", "aliases": ["G-protein coupled neurotensin receptor activity", "neurotensin receptor activity, G protein coupled", "neurotensin receptor activity, G-protein coupled", "G protein coupled neurotensin receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled neurotensin receptor activity", "definition": "Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. [PMID:10390649]"}
{"concept_id": "C1149142", "aliases": [], "types": ["T044"], "canonical_name": "opioid receptor activity"}
{"concept_id": "C1149143", "aliases": [], "types": ["T044"], "canonical_name": "delta-opioid receptor activity", "definition": "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands. [IUPHAR_RECEPTOR:317, PMID:10471416]"}
{"concept_id": "C1149144", "aliases": [], "types": ["T044"], "canonical_name": "kappa-opioid receptor activity", "definition": "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins. [IUPHAR_RECEPTOR:318]"}
{"concept_id": "C1149145", "aliases": ["mu-opioid receptor activity"], "types": ["T044"], "canonical_name": "mu-opioid receptor activity", "definition": "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. [IUPHAR_RECEPTOR:319]"}
{"concept_id": "C1149146", "aliases": [], "types": ["T044"], "canonical_name": "X-opioid receptor activity", "definition": "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors. [InterPro:IPR001420]"}
{"concept_id": "C1149147", "aliases": [], "types": ["T044"], "canonical_name": "orexin receptor activity", "definition": "Combining with orexin to initiate a change in cell activity. [GOC:ai]"}
{"concept_id": "C1149148", "aliases": ["protease-activated receptor activity", "proteinase activated receptor activity"], "types": ["T044"], "canonical_name": "proteinase-activated receptor activity", "definition": "A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. [GOC:mah, PMID:11356985, PMID:33742547]"}
{"concept_id": "C1149149", "aliases": ["growth hormone-inhibiting hormone receptor activity", "GHIH receptor activity", "SST receptor activity", "SRIF receptor activity", "somatostatin receptor activity"], "types": ["T044"], "definition": "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). [GOC:ai, GOC:bf, Wikipedia:Somatostatin]", "canonical_name": "somatotrophin release inhibiting factor receptor activity"}
{"concept_id": "C1149150", "aliases": ["thrombin-activated receptor activity", "thrombin receptor activity, G-protein coupled"], "types": ["T044"], "definition": "A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. [GOC:ai, GOC:pg, PMID:20423334]", "canonical_name": "thrombin receptor activity"}
{"concept_id": "C1149151", "aliases": [], "types": ["T044"], "canonical_name": "urotensin II receptor activity", "definition": "Combining with urotensin II to initiate a change in cell activity. [GOC:mah, PMID:15102493]"}
{"concept_id": "C1149153", "aliases": [], "types": ["T044"], "definition": "Combining with oxytocin to initiate a change in cell activity. [GOC:ai]", "canonical_name": "oxytocin receptor activity"}
{"concept_id": "C1149154", "aliases": [], "types": ["T044"], "definition": "Combining with vasopressin to initiate a change in cell activity. [GOC:ai]", "canonical_name": "vasopressin receptor activity"}
{"concept_id": "C1149155", "aliases": [], "types": ["T044"], "canonical_name": "phosphate ion binding", "definition": "Binding to a phosphate ion. [GOC:jl]"}
{"concept_id": "C1149156", "aliases": [], "types": ["T044"], "canonical_name": "polyamine binding", "definition": "Binding to a polyamine, an organic compound containing two or more amino groups. [GOC:ai]"}
{"concept_id": "C1149157", "aliases": [], "types": ["T044"], "canonical_name": "putrescine binding", "definition": "Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. [GOC:ai]"}
{"concept_id": "C1149158", "aliases": [], "types": ["T044"], "canonical_name": "spermidine binding", "definition": "Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]"}
{"concept_id": "C1149159", "aliases": [], "types": ["T044"], "canonical_name": "alpha-catenin binding", "definition": "Binding to catenin complex alpha subunit. [GOC:bf]"}
{"concept_id": "C1149161", "aliases": ["beta-amyloid binding"], "types": ["T044"], "canonical_name": "amyloid-beta binding", "definition": "Binding to an amyloid-beta peptide/protein. [GOC:hjd]"}
{"concept_id": "C1149162", "aliases": [], "types": ["T044"], "canonical_name": "beta-catenin binding", "definition": "Binding to a catenin beta subunit. [GOC:bf]"}
{"concept_id": "C1149163", "aliases": [], "types": ["T044"], "canonical_name": "cadherin binding", "definition": "Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf]"}
{"concept_id": "C1149164", "aliases": [], "types": ["T044"], "canonical_name": "calmodulin binding", "definition": "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]"}
{"concept_id": "C1149166", "aliases": [], "types": ["T044"], "canonical_name": "clathrin binding", "definition": "Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. [GOC:jl, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1149167", "aliases": [], "types": ["T044"], "canonical_name": "collagen binding", "definition": "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1149168", "aliases": [], "types": ["T044"], "canonical_name": "cyclin binding", "definition": "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. [GOC:ai]"}
{"concept_id": "C1149169", "aliases": [], "types": ["T044"], "canonical_name": "cytokine binding", "definition": "Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. [GOC:ai, GOC:bf, ISBN:0198599471]"}
{"concept_id": "C1149170", "aliases": [], "types": ["T044"], "canonical_name": "chemokine binding", "definition": "Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:ai, GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]"}
{"concept_id": "C1149171", "aliases": [], "types": ["T044"], "canonical_name": "C-C chemokine binding", "definition": "Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]"}
{"concept_id": "C1149172", "aliases": [], "types": ["T044"], "canonical_name": "C-X-C chemokine binding", "definition": "Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:ai]"}
{"concept_id": "C1149173", "aliases": ["interleukin-8 binding"], "types": ["T044"], "definition": "Binding to interleukin-8. [GOC:jl]", "canonical_name": "IL-8 binding"}
{"concept_id": "C1149174", "aliases": [], "types": ["T044"], "canonical_name": "C-X3-C chemokine binding", "definition": "Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]"}
{"concept_id": "C1149175", "aliases": ["granulocyte macrophage colony stimulating factor complex binding", "GM-CSF complex binding", "GMC-SF complex binding"], "types": ["T044"], "canonical_name": "granulocyte macrophage colony-stimulating factor complex binding", "definition": "Binding to a granulocyte macrophage colony-stimulating factor complex. [GOC:ai]"}
{"concept_id": "C1149176", "aliases": ["IFN binding"], "types": ["T044"], "canonical_name": "interferon binding", "definition": "Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent. [PMID:9607096, Wikipedia:Interferon]"}
{"concept_id": "C1149177", "aliases": ["IFN receptor activity"], "types": ["T044"], "definition": "Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling, PMID:9607096]", "canonical_name": "interferon receptor activity"}
{"concept_id": "C1149178", "aliases": [], "types": ["T044"], "canonical_name": "interferon-alpha/beta receptor activity"}
{"concept_id": "C1149179", "aliases": ["IFN-gamma receptor activity", "type II interferon receptor activity", "IFNG receptor activity"], "types": ["T044"], "canonical_name": "interferon-gamma receptor activity", "definition": "Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:ai, GOC:signaling, ISBN:0126896631, PMID:15546383]"}
{"concept_id": "C1149180", "aliases": [], "types": ["T044"], "canonical_name": "interferon-alpha/beta binding"}
{"concept_id": "C1149181", "aliases": ["IFNG binding", "interferon-gamma binding", "type II interferon binding"], "types": ["T044"], "definition": "Binding to interferon-gamma. Interferon gamma is the only member of the type II interferon found so far. [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383]", "canonical_name": "IFN-gamma binding"}
{"concept_id": "C1149182", "aliases": [], "types": ["T044"], "canonical_name": "interleukin binding"}
{"concept_id": "C1149183", "aliases": ["interleukin receptor activity"], "types": ["T044"], "canonical_name": "IL receptor"}
{"concept_id": "C1149184", "aliases": ["IL-1R", "IL-1 receptor activity"], "types": ["T044"], "canonical_name": "interleukin-1 receptor activity", "definition": "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. [GOC:jl]"}
{"concept_id": "C1149185", "aliases": ["interleukin-1, type I, activating binding", "interleukin-1 type I receptor activity", "interleukin-1 activating receptor activity", "IL-1 type I, activating receptor", "IL-1 type I, activating binding"], "types": ["T044"], "canonical_name": "interleukin-1, type I, activating receptor activity", "definition": "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. [PMID:15062641, PMID:18613828]"}
{"concept_id": "C1149186", "aliases": ["IL-1 type II, blocking binding", "interleukin-1 type II receptor activity", "IL-1 type II, blocking receptor", "interleukin-1, type II, blocking binding", "interleukin-1 blocking receptor activity"], "types": ["T044"], "canonical_name": "interleukin-1, type II, blocking receptor activity", "definition": "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors. [PMID:15062641, PMID:18613828]"}
{"concept_id": "C1149187", "aliases": ["IL-10 receptor activity", "interleukin-10 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-10R"}
{"concept_id": "C1149188", "aliases": ["IL-11 receptor activity", "gp130", "interleukin-11 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-11R"}
{"concept_id": "C1149189", "aliases": ["interleukin-12 receptor activity", "IL-12 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-12R"}
{"concept_id": "C1149190", "aliases": ["interleukin-13 receptor activity", "IL-13R"], "types": ["T044"], "definition": "Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-13 receptor activity"}
{"concept_id": "C1149192", "aliases": ["interleukin-15 receptor activity", "IL-15 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-15R"}
{"concept_id": "C1149193", "aliases": ["interleukin-16 receptor activity", "IL-16 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-16R"}
{"concept_id": "C1149194", "aliases": ["IL-17 receptor activity", "IL-17R"], "types": ["T044"], "definition": "Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:jl, GOC:signaling]", "canonical_name": "interleukin-17 receptor activity"}
{"concept_id": "C1149195", "aliases": ["interleukin-18 receptor activity", "IL-18R"], "types": ["T044"], "definition": "Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-18 receptor activity"}
{"concept_id": "C1149196", "aliases": ["IL-19 receptor activity", "IL-19R"], "types": ["T044"], "canonical_name": "interleukin-19 receptor activity", "definition": "Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]"}
{"concept_id": "C1149197", "aliases": ["IL-2 receptor activity", "IL-2R"], "types": ["T044"], "definition": "Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "interleukin-2 receptor activity"}
{"concept_id": "C1149198", "aliases": ["IL-20R", "IL-20 receptor activity"], "types": ["T044"], "canonical_name": "interleukin-20 receptor activity", "definition": "Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]"}
{"concept_id": "C1149199", "aliases": ["IL-21R", "interleukin-21 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-21 receptor activity"}
{"concept_id": "C1149200", "aliases": ["IL-22 receptor activity", "interleukin-22 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-22R"}
{"concept_id": "C1149201", "aliases": ["IL-23 receptor activity", "interleukin-23 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-23R"}
{"concept_id": "C1149202", "aliases": ["IL-24R", "IL-24 receptor activity"], "types": ["T044"], "canonical_name": "interleukin-24 receptor activity", "definition": "Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]"}
{"concept_id": "C1149203", "aliases": ["IL-25 receptor activity", "IL-25R"], "types": ["T044"], "definition": "Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "interleukin-25 receptor activity"}
{"concept_id": "C1149204", "aliases": ["IL-26R", "IL-26 receptor activity"], "types": ["T044"], "canonical_name": "interleukin-26 receptor activity", "definition": "Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]"}
{"concept_id": "C1149205", "aliases": ["IL-27 receptor activity", "interleukin-27 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-27R"}
{"concept_id": "C1149206", "aliases": ["interleukin-3 receptor activity", "IL-3R"], "types": ["T044"], "definition": "Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-3 receptor activity"}
{"concept_id": "C1149207", "aliases": ["IL-4 receptor activity", "interleukin-4 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-4R"}
{"concept_id": "C1149208", "aliases": ["IL-5 receptor activity", "IL-5R"], "types": ["T044"], "definition": "Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "interleukin-5 receptor activity"}
{"concept_id": "C1149209", "aliases": ["interleukin-6 receptor activity", "IL-6 receptor activity"], "types": ["T044"], "definition": "Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "canonical_name": "IL-6R"}
{"concept_id": "C1149210", "aliases": ["IL-7R", "IL-7 receptor activity"], "types": ["T044"], "canonical_name": "interleukin-7 receptor activity", "definition": "Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]"}
{"concept_id": "C1149211", "aliases": ["IL-9R", "IL-9 receptor activity"], "types": ["T044"], "canonical_name": "interleukin-9 receptor activity", "definition": "Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]"}
{"concept_id": "C1149212", "aliases": ["interleukin-1 binding", "IL-1"], "types": ["T044"], "definition": "Binding to interleukin-1. [GOC:jl, ISBN:0198506732]", "canonical_name": "IL-1 binding"}
{"concept_id": "C1149215", "aliases": ["interleukin-10 binding", "IL-10 binding"], "types": ["T044"], "definition": "Binding to interleukin-10. [GOC:jl]", "canonical_name": "IL-10"}
{"concept_id": "C1149216", "aliases": ["IL-11 binding", "interleukin-11 binding"], "types": ["T044"], "definition": "Binding to interleukin-11. [GOC:jl]", "canonical_name": "IL-11"}
{"concept_id": "C1149217", "aliases": ["IL-12", "IL-12 binding"], "types": ["T044"], "definition": "Binding to interleukin-12. [GOC:jl]", "canonical_name": "interleukin-12 binding"}
{"concept_id": "C1149218", "aliases": ["IL-12A binding", "IL-12p35 binding", "NKSFp35 binding", "CLMFp35 binding"], "types": ["T044"], "canonical_name": "interleukin-12 alpha subunit binding", "definition": "Binding to the alpha subunit of interleukin-12. [GOC:mah]"}
{"concept_id": "C1149219", "aliases": ["IL-12B binding", "NKSFp40 binding", "IL-12p40 binding", "CLMFp40 binding"], "types": ["T044"], "canonical_name": "interleukin-12 beta subunit binding", "definition": "Binding to the beta subunit of interleukin-12. [GOC:mah]"}
{"concept_id": "C1149220", "aliases": ["IL-13 binding", "IL-13"], "types": ["T044"], "definition": "Binding to interleukin-13. [GOC:jl]", "canonical_name": "interleukin-13 binding"}
{"concept_id": "C1149222", "aliases": ["interleukin-15 binding", "IL-15 binding"], "types": ["T044"], "definition": "Binding to interleukin-15. [GOC:jl]", "canonical_name": "IL-15"}
{"concept_id": "C1149223", "aliases": ["IL-16", "IL-16 binding"], "types": ["T044"], "definition": "Binding to interleukin-16. [GOC:jl]", "canonical_name": "interleukin-16 binding"}
{"concept_id": "C1149224", "aliases": ["IL-17 binding"], "types": ["T044"], "canonical_name": "interleukin-17 binding", "definition": "Binding to a member of the interleukin-17 family of cytokines. [GOC:add, GOC:jl]"}
{"concept_id": "C1149225", "aliases": ["IL-18", "interleukin-18 binding"], "types": ["T044"], "definition": "Binding to interleukin-18. [GOC:jl]", "canonical_name": "IL-18 binding"}
{"concept_id": "C1149228", "aliases": ["IL-19", "IL-19 binding"], "types": ["T044"], "definition": "Binding to interleukin-19. [GOC:jl]", "canonical_name": "interleukin-19 binding"}
{"concept_id": "C1149229", "aliases": ["interleukin-2 binding", "IL-2 binding"], "types": ["T044"], "definition": "Binding to interleukin-2. [GOC:jl]", "canonical_name": "IL-2"}
{"concept_id": "C1149230", "aliases": ["interleukin-20 binding", "IL-20 binding"], "types": ["T044"], "definition": "Binding to interleukin-20. [GOC:jl]", "canonical_name": "IL-20"}
{"concept_id": "C1149231", "aliases": ["IL-21", "IL-21 binding"], "types": ["T044"], "definition": "Binding to interleukin-21. [GOC:jl]", "canonical_name": "interleukin-21 binding"}
{"concept_id": "C1149232", "aliases": ["IL-22", "interleukin-22 binding"], "types": ["T044"], "definition": "Binding to interleukin-22. [GOC:jl]", "canonical_name": "IL-22 binding"}
{"concept_id": "C1149233", "aliases": ["interleukin-23 binding", "IL-23"], "types": ["T044"], "definition": "Binding to interleukin-23. [GOC:jl]", "canonical_name": "IL-23 binding"}
{"concept_id": "C1149234", "aliases": ["IL-24 binding", "IL-24"], "types": ["T044"], "definition": "Binding to interleukin-24. [GOC:go_curators]", "canonical_name": "interleukin-24 binding"}
{"concept_id": "C1149235", "aliases": ["IL-25", "IL-25 binding"], "types": ["T044"], "definition": "Binding to interleukin-25. [GOC:go_curators]", "canonical_name": "interleukin-25 binding"}
{"concept_id": "C1149236", "aliases": ["interleukin-26 binding", "IL-26 binding"], "types": ["T044"], "definition": "Binding to interleukin-26. [GOC:go_curators]", "canonical_name": "IL-26"}
{"concept_id": "C1149237", "aliases": ["IL-27 binding"], "types": ["T044"], "definition": "Binding to interleukin-27. [GOC:go_curators]", "canonical_name": "interleukin-27 binding"}
{"concept_id": "C1149238", "aliases": ["IL-3", "interleukin-3 binding"], "types": ["T044"], "definition": "Binding to interleukin-3. [GOC:jl]", "canonical_name": "IL-3 binding"}
{"concept_id": "C1149239", "aliases": ["IL-4", "IL-4 binding"], "types": ["T044"], "definition": "Binding to interleukin-4. [GOC:jl]", "canonical_name": "interleukin-4 binding"}
{"concept_id": "C1149240", "aliases": ["interleukin-5 binding", "IL-5"], "types": ["T044"], "definition": "Binding to interleukin-5. [GOC:jl]", "canonical_name": "IL-5 binding"}
{"concept_id": "C1149241", "aliases": ["interleukin-6 binding", "IL-6 binding"], "types": ["T044"], "definition": "Binding to interleukin-6. [GOC:jl]", "canonical_name": "IL-6"}
{"concept_id": "C1149242", "aliases": ["interleukin-7 binding", "IL-7 binding"], "types": ["T044"], "definition": "Binding to interleukin-7. [GOC:jl]", "canonical_name": "IL-7"}
{"concept_id": "C1149243", "aliases": ["interleukin-9 binding", "IL-9 binding"], "types": ["T044"], "definition": "Binding to interleukin-9. [GOC:jl]", "canonical_name": "IL-9"}
{"concept_id": "C1149244", "aliases": [], "types": ["T044"], "canonical_name": "cytoskeletal protein binding", "definition": "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). [GOC:mah]"}
{"concept_id": "C1149245", "aliases": [], "types": ["T044"], "canonical_name": "actin binding", "definition": "Binding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt]"}
{"concept_id": "C1149247", "aliases": [], "types": ["T044"], "canonical_name": "actin cross-linking activity", "definition": "OBSOLETE. Interacting selectively with two actin filaments to anchor them together. [GOC:jid]"}
{"concept_id": "C1149250", "aliases": [], "types": ["T044"], "canonical_name": "actin lateral binding", "definition": "Binding to an actin filament along its length. [GOC:mah]"}
{"concept_id": "C1149251", "aliases": [], "types": ["T044"], "canonical_name": "actin modulating activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149252", "aliases": ["G actin binding"], "types": ["T044"], "canonical_name": "actin monomer binding", "definition": "Binding to monomeric actin, also known as G-actin. [GOC:ai]"}
{"concept_id": "C1149253", "aliases": [], "types": ["T044"], "canonical_name": "actin monomer sequestering activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1149257", "aliases": [], "types": ["T043"], "canonical_name": "barbed-end actin capping/severing activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149258", "aliases": [], "types": ["T044"], "canonical_name": "membrane associated actin binding", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149260", "aliases": [], "types": ["T044"], "canonical_name": "ankyrin binding", "definition": "Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1149261", "aliases": ["cytoskeletal adaptor activity"], "types": ["T044"], "canonical_name": "cytoskeletal anchor activity", "definition": "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane. [ISBN:0198599323]"}
{"concept_id": "C1149263", "aliases": [], "types": ["T044"], "canonical_name": "cytoskeletal regulatory protein binding", "definition": "Binding to a protein involved in modulating the reorganization of the cytoskeleton. [GOC:go_curators, PMID:15163540]"}
{"concept_id": "C1149264", "aliases": [], "types": ["T044"], "canonical_name": "kinesin binding", "definition": "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. [GOC:curators, PMID:8606779]"}
{"concept_id": "C1149266", "aliases": [], "types": ["T044"], "canonical_name": "myosin binding", "definition": "Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. [GOC:mah]"}
{"concept_id": "C1149267", "aliases": [], "types": ["T044"], "canonical_name": "myosin I binding", "definition": "Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments. [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1149268", "aliases": [], "types": ["T044"], "canonical_name": "myosin II binding", "definition": "Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1149269", "aliases": ["myosin phosphatase myosin binding"], "types": ["T044"], "canonical_name": "myosin phosphatase myosin binding", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149270", "aliases": [], "types": ["T044"], "canonical_name": "spectrin binding", "definition": "Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1149271", "aliases": [], "types": ["T044"], "canonical_name": "tropomyosin binding", "definition": "Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. [GOC:curators, ISBN:0815316194]"}
{"concept_id": "C1149272", "aliases": [], "types": ["T044"], "canonical_name": "troponin C binding", "definition": "Binding to troponin C, the calcium-binding subunit of the troponin complex. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1149274", "aliases": [], "types": ["T044"], "canonical_name": "microtubule binding", "definition": "Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc]"}
{"concept_id": "C1149275", "aliases": ["ATP-dependent microtubule motor activity"], "types": ["T044"], "definition": "A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. [PMID:19686686, PMID:32684327, PMID:32842864]", "canonical_name": "microtubule motor activity"}
{"concept_id": "C1149276", "aliases": [], "types": ["T044"], "canonical_name": "kinesin motor activity", "definition": "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules. [GOC:hb]"}
{"concept_id": "C1149277", "aliases": ["ATP-dependent minus-end-directed microtubule motor activity", "microtubule motor activity, minus-end-directed", "minus-end-directed ATP-dependent microtubule motor activity", "kinesin ATP phosphohydrolase (minus-end-directed)", "minus-end-directed kinesin ATPase activity", "ATP-dependent microtubule motor activity, minus-end-directed"], "types": ["T044"], "canonical_name": "minus-end-directed microtubule motor activity", "definition": "A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis. [GOC:mah, GOC:vw, PMID:15659646, PMID:32842864]"}
{"concept_id": "C1149278", "aliases": ["ATP-dependent microtubule motor activity, plus-end-directed", "plus-end-directed kinesin ATPase activity", "plus-end-directed ATP-dependent microtubule motor activity", "ATP-dependent plus-end-directed microtubule motor activity", "microtubule motor activity, plus-end-directed", "kinesin ATP phosphohydrolase (plus-end-directed)"], "types": ["T044"], "canonical_name": "plus-end-directed microtubule motor activity", "definition": "A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. [GOC:vw, PMID:32842864]"}
{"concept_id": "C1149279", "aliases": ["microtubule severing activity"], "types": ["T044"], "canonical_name": "microtubule severing activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149280", "aliases": [], "types": ["T044"], "canonical_name": "vinculin binding", "definition": "Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. [ISBN:0721662544]"}
{"concept_id": "C1149282", "aliases": [], "types": ["T044"], "canonical_name": "dynein binding"}
{"concept_id": "C1149283", "aliases": [], "types": ["T044"], "canonical_name": "dynein heavy chain binding", "definition": "Binding to a heavy chain of the dynein complex. [GOC:bf]"}
{"concept_id": "C1149284", "aliases": [], "types": ["T044"], "canonical_name": "dynein intermediate chain binding", "definition": "Binding to an intermediate chain of the dynein complex. [GOC:bf]"}
{"concept_id": "C1149285", "aliases": [], "types": ["T044"], "canonical_name": "dynein light chain binding", "definition": "Binding to a light chain of the dynein complex. [GOC:bf]"}
{"concept_id": "C1149286", "aliases": [], "types": ["T044"], "canonical_name": "enzyme binding", "definition": "Binding to an enzyme, a protein with catalytic activity. [GOC:jl]"}
{"concept_id": "C1149287", "aliases": ["adenylyl cyclase binding"], "types": ["T044"], "canonical_name": "adenylate cyclase binding", "definition": "Binding to an adenylate cyclase. [GOC:jl]"}
{"concept_id": "C1149288", "aliases": [], "types": ["T044"], "canonical_name": "DEAD/H-box RNA helicase binding", "definition": "Binding to a DEAD/H-box RNA helicase. [GOC:jl]"}
{"concept_id": "C1149289", "aliases": [], "types": ["T044"], "canonical_name": "kinase binding", "definition": "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]"}
{"concept_id": "C1149290", "aliases": [], "types": ["T044"], "canonical_name": "protein kinase binding", "definition": "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]"}
{"concept_id": "C1149291", "aliases": ["JNK binding"], "types": ["T044"], "canonical_name": "JUN kinase binding", "definition": "Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. [GOC:jl]"}
{"concept_id": "C1149293", "aliases": [], "types": ["T044"], "canonical_name": "phosphatase binding", "definition": "Binding to a phosphatase. [GOC:jl]"}
{"concept_id": "C1149294", "aliases": ["calcineurin binding"], "types": ["T044"], "canonical_name": "protein phosphatase 2B binding", "definition": "Binding to a protein phosphatase 2B. [GOC:jl]"}
{"concept_id": "C1149295", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase binding", "definition": "Binding to a protein phosphatase. [GOC:jl]"}
{"concept_id": "C1149296", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 1 binding", "definition": "Binding to a protein phosphatase 1. [GOC:jl]"}
{"concept_id": "C1149297", "aliases": ["eIF4E binding"], "types": ["T045"], "canonical_name": "eukaryotic initiation factor 4E binding", "definition": "Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. [ISBN:0198506732]"}
{"concept_id": "C1149298", "aliases": ["plakoglobin binding"], "types": ["T044"], "canonical_name": "gamma-catenin binding", "definition": "Binding to catenin complex gamma subunit. [GOC:bf]"}
{"concept_id": "C1149299", "aliases": [], "types": ["T044"], "definition": "Growth Factor Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction and often spatial complementarity with extracellular signaling molecules (ligands) involved in the control of target cell proliferation, survival, and differentiation.", "canonical_name": "growth factor binding"}
{"concept_id": "C1149300", "aliases": ["fibroblast growth factor binding", "FGF binding"], "types": ["T044"], "definition": "Binding to a fibroblast growth factor. [PMID:9806903]", "canonical_name": "fibroblast growth factor"}
{"concept_id": "C1149301", "aliases": ["IGF binding"], "types": ["T044"], "canonical_name": "insulin-like growth factor binding", "definition": "Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. [ISBN:0198506732]"}
{"concept_id": "C1149302", "aliases": ["haemoglobin binding"], "types": ["T044"], "canonical_name": "hemoglobin binding", "definition": "Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:jl]"}
{"concept_id": "C1149303", "aliases": [], "types": ["T044"], "canonical_name": "histone binding", "definition": "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]"}
{"concept_id": "C1149304", "aliases": [], "types": ["T044"], "canonical_name": "Hsp70 protein binding", "definition": "Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. [ISBN:0198506732]"}
{"concept_id": "C1149306", "aliases": [], "types": ["T044"], "canonical_name": "immunoglobulin binding", "definition": "Binding to an immunoglobulin. [GOC:ma]"}
{"concept_id": "C1149307", "aliases": [], "types": ["T044"], "canonical_name": "IgA binding", "definition": "Binding to an immunoglobulin of an IgA isotype. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1149308", "aliases": [], "types": ["T044"], "definition": "Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]", "canonical_name": "IgA receptor activity"}
{"concept_id": "C1149309", "aliases": [], "types": ["T044"], "canonical_name": "IgE binding", "definition": "Binding to an immunoglobulin of the IgE isotype. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1149310", "aliases": [], "types": ["T044"], "canonical_name": "IgE receptor activity", "definition": "Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1149311", "aliases": ["high affinity IgE receptor activity"], "types": ["T044"], "canonical_name": "high-affinity IgE receptor activity", "definition": "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1149312", "aliases": ["low-affinity IgE receptor activity"], "types": ["T044"], "definition": "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]", "canonical_name": "low affinity IgE receptor activity"}
{"concept_id": "C1149313", "aliases": [], "types": ["T044"], "canonical_name": "IgG binding", "definition": "Binding to an immunoglobulin of an IgG isotype. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1149314", "aliases": [], "types": ["T044"], "canonical_name": "IgG receptor activity", "definition": "Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1149315", "aliases": ["high affinity IgG receptor activity"], "types": ["T044"], "canonical_name": "high-affinity IgG receptor activity", "definition": "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1149316", "aliases": [], "types": ["T044"], "canonical_name": "leucokinin receptor activity", "definition": "Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:2716741]"}
{"concept_id": "C1149317", "aliases": ["low affinity IgG receptor activity"], "types": ["T044"], "canonical_name": "low-affinity IgG receptor activity", "definition": "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1149318", "aliases": [], "types": ["T044"], "canonical_name": "importin-alpha export receptor activity"}
{"concept_id": "C1149319", "aliases": [], "types": ["T044"], "canonical_name": "intermediate filament binding", "definition": "Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. [ISBN:0198506732]"}
{"concept_id": "C1149322", "aliases": [], "types": ["T044"], "canonical_name": "lamin binding", "definition": "Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1149323", "aliases": [], "types": ["T044"], "canonical_name": "lipoprotein binding", "definition": "OBSOLETE. Binding to a conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1149324", "aliases": ["diacylated lipopeptide binding"], "types": ["T044"], "canonical_name": "diacyl lipopeptide binding", "definition": "Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]"}
{"concept_id": "C1149325", "aliases": ["HDL binding"], "types": ["T044"], "canonical_name": "high-density lipoprotein particle binding", "definition": "Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. [GOC:mah]"}
{"concept_id": "C1149326", "aliases": ["LDL binding"], "types": ["T044"], "canonical_name": "low-density lipoprotein particle binding", "definition": "Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. [GOC:mah]"}
{"concept_id": "C1149327", "aliases": ["LDLR activity", "low-density lipoprotein receptor activity", "low-density lipoprotein particle receptor activity"], "types": ["T044"], "definition": "Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis. [GOC:bf, ISBN:0198506732]", "canonical_name": "LDL receptor"}
{"concept_id": "C1149330", "aliases": [], "types": ["T044"], "canonical_name": "neurexin family protein binding", "definition": "Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. [GOC:curators, GOC:pr, PMID:18923512]"}
{"concept_id": "C1149331", "aliases": ["nuclear localisation sequence binding", "nuclear localization signal binding", "NLS binding"], "types": ["T044"], "canonical_name": "nuclear localization sequence binding", "definition": "Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. [GOC:ai]"}
{"concept_id": "C1149332", "aliases": ["PTS binding"], "types": ["T044"], "canonical_name": "peroxisome targeting sequence binding", "definition": "Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome. [GOC:mah, ISBN:0879693568]"}
{"concept_id": "C1149334", "aliases": ["peroxisome targeting signal-1 binding", "PTS1 binding", "peroxisomal targeting signal 1 (PTS1) binding"], "types": ["T044"], "canonical_name": "peroxisome matrix targeting signal-1 binding", "definition": "Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L. [GOC:mah, PMID:11687502]"}
{"concept_id": "C1149335", "aliases": ["peroxisomal targeting signal 2 (PTS2) binding", "PTS2 receptor", "peroxisome targeting signal-2 binding", "peroxisome targeting signal-2 receptor", "PEX7", "PTS2 binding"], "types": ["T044"], "definition": "Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F). [GOC:mah, PMID:11687502]", "canonical_name": "peroxisome matrix targeting signal-2 binding"}
{"concept_id": "C1149336", "aliases": [], "types": ["T044"], "canonical_name": "poly-glutamine tract binding", "definition": "Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein. [GOC:mah]"}
{"concept_id": "C1149337", "aliases": [], "types": ["T044"], "canonical_name": "profilin binding", "definition": "Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin. [ISBN:0721662544]"}
{"concept_id": "C1149339", "aliases": [], "types": ["T044"], "canonical_name": "phosphoprotein amino acid binding"}
{"concept_id": "C1149341", "aliases": ["carboxyl-terminus binding", "COOH-terminus binding", "carboxyl-terminal binding", "carboxylate-terminus binding", "C-terminal end binding", "COOH-terminal binding", "carboxy-terminal binding", "carboxy-terminus binding", "C-terminal binding"], "types": ["T044"], "canonical_name": "protein C-terminus binding", "definition": "Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. [ISBN:0198506732]"}
{"concept_id": "C1149343", "aliases": ["protein domain-specific binding"], "types": ["T044"], "canonical_name": "protein domain specific binding", "definition": "Binding to a specific domain of a protein. [GOC:go_curators]"}
{"concept_id": "C1149344", "aliases": [], "types": ["T044"], "canonical_name": "FH1 domain binding", "definition": "Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain. [GOC:go_curators]"}
{"concept_id": "C1149345", "aliases": [], "types": ["T044"], "canonical_name": "LIM domain binding", "definition": "Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. [GOC:go_curators, Pfam:PF00412]"}
{"concept_id": "C1149346", "aliases": [], "types": ["T044"], "canonical_name": "LRR domain binding", "definition": "Binding to a LRR domain (leucine rich repeats) of a protein. [GOC:go_curators, Pfam:PF00560]"}
{"concept_id": "C1149347", "aliases": ["GLGF-domain binding", "DHR-domain binding"], "types": ["T044"], "canonical_name": "PDZ domain binding", "definition": "Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595]"}
{"concept_id": "C1149348", "aliases": [], "types": ["T044"], "canonical_name": "SH2 domain binding", "definition": "Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. [GOC:go_curators, Pfam:PF00017]"}
{"concept_id": "C1149349", "aliases": [], "types": ["T044"], "canonical_name": "SH3 domain binding", "definition": "Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]"}
{"concept_id": "C1149356", "aliases": [], "types": ["T044"], "canonical_name": "SMAD binding", "definition": "Binding to a SMAD signaling protein. [GOC:ai]"}
{"concept_id": "C1149357", "aliases": ["SNAP receptor binding"], "types": ["T044"], "canonical_name": "SNARE binding", "definition": "Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. [PMID:12642621]"}
{"concept_id": "C1149358", "aliases": [], "types": ["T044"], "canonical_name": "syntaxin binding", "definition": "Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. [ISBN:0198506732]"}
{"concept_id": "C1149359", "aliases": [], "types": ["T044"], "canonical_name": "syntaxin-1 binding", "definition": "Binding to a syntaxin-1 SNAP receptor. [GOC:ai]"}
{"concept_id": "C1149362", "aliases": [], "types": ["T044"], "canonical_name": "syntaxin-3 binding", "definition": "Binding to a syntaxin-3 SNAP receptor. [GOC:ai]"}
{"concept_id": "C1149363", "aliases": [], "types": ["T045"], "canonical_name": "snoRNP binding", "definition": "Binding to a small nucleolar ribonucleoprotein particle. [GOC:mah]"}
{"concept_id": "C1149364", "aliases": [], "types": ["T044"], "canonical_name": "syndecan binding", "definition": "Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. [GOC:go_curators, PMID:9355727]"}
{"concept_id": "C1149365", "aliases": ["TBP binding"], "types": ["T044"], "canonical_name": "TATA-binding protein binding"}
{"concept_id": "C1149366", "aliases": ["TRAIL binding", "Apo-2L binding"], "types": ["T044"], "canonical_name": "TRAIL binding", "definition": "Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. [GOC:go_curators, PMID:9082980]"}
{"concept_id": "C1149367", "aliases": ["TF binding"], "types": ["T045"], "canonical_name": "transcription factor binding", "definition": "Binding to a transcription factor, a protein required to initiate or regulate transcription. [ISBN:0198506732]"}
{"concept_id": "C1149368", "aliases": [], "types": ["T044"], "canonical_name": "aryl hydrocarbon receptor binding", "definition": "Binding to an aryl hydrocarbon receptor. [GOC:ai]"}
{"concept_id": "C1149369", "aliases": [], "types": ["T044"], "canonical_name": "estrogen receptor binding"}
{"concept_id": "C1149370", "aliases": ["transcription cofactor activity", "transcriptional co-regulator"], "types": ["T045"], "canonical_name": "transcription coregulator activity", "definition": "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]"}
{"concept_id": "C1149371", "aliases": ["transcription co-activator activity"], "types": ["T045"], "canonical_name": "transcription coactivator activity", "definition": "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]"}
{"concept_id": "C1149372", "aliases": ["cAMP response element binding protein binding", "CBP", "3',5' cAMP response element binding protein binding", "cyclic AMP response element binding protein binding", "adenosine 3',5'-cyclophosphate response element binding protein binding", "3',5'-cAMP response element binding protein binding"], "types": ["T045"], "definition": "Binding to a cAMP response element binding protein (a CREB protein). [GOC:mah]", "canonical_name": "CREB binding"}
{"concept_id": "C1149373", "aliases": ["ligand-dependent nuclear receptor transcription coactivator activity", "ligand-activated RNA polymerase II transcription factor binding transcription factor activity", "ligand-dependent nuclear receptor transcription co-activator activity", "nuclear receptor transcription coactivator activity", "transcription factor activity, ligand-activated RNA polymerase II transcription factor binding"], "types": ["T044"], "canonical_name": "nuclear receptor coactivator activity", "definition": "A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:dph, GOC:tb]"}
{"concept_id": "C1149375", "aliases": ["transcription co-repressor activity"], "types": ["T045"], "canonical_name": "transcription corepressor activity", "definition": "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]"}
{"concept_id": "C1149377", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-protein binding", "definition": "Binding to a Wnt-protein, a secreted growth factor involved in signaling. [GOC:jl]"}
{"concept_id": "C1149378", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxal phosphate binding", "definition": "Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1149379", "aliases": ["baboon binding"], "types": ["T044"], "canonical_name": "babo binding"}
{"concept_id": "C1149380", "aliases": [], "types": ["T044"], "canonical_name": "benzodiazepine receptor binding", "definition": "Binding to a peripheral benzodiazepine receptor (PBR). [GOC:ceb, GOC:mah, PMID:9915832]"}
{"concept_id": "C1149381", "aliases": [], "types": ["T044"], "definition": "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. [GOC:go_curators, ISBN:0198506732]", "canonical_name": "chemoattractant activity"}
{"concept_id": "C1149382", "aliases": [], "types": ["T044"], "definition": "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]", "canonical_name": "chemokine activity"}
{"concept_id": "C1149383", "aliases": ["chemorepellant activity"], "types": ["T044"], "canonical_name": "chemorepellent activity", "definition": "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. [GOC:ai]"}
{"concept_id": "C1149384", "aliases": [], "types": ["T044"], "definition": "The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]", "canonical_name": "cytokine activity"}
{"concept_id": "C1149390", "aliases": [], "types": ["T044"], "canonical_name": "gurken receptor binding", "definition": "Binding to a gurken growth factor receptor. [GOC:ai]"}
{"concept_id": "C1149391", "aliases": ["FGFR binding", "FGF receptor binding"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor binding", "definition": "Binding to a fibroblast growth factor receptor (FGFR). [GOC:ceb]"}
{"concept_id": "C1149392", "aliases": ["FGFR antagonist activity", "FGF receptor antagonist activity"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor antagonist activity", "definition": "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist. [GOC:mah]"}
{"concept_id": "C1149393", "aliases": ["IL-1ra"], "types": ["T044"], "definition": "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. [GOC:ebc]", "canonical_name": "interleukin-1 receptor antagonist activity"}
{"concept_id": "C1149394", "aliases": ["IL-1ra type I"], "types": ["T044"], "canonical_name": "interleukin-1 type I receptor antagonist activity", "definition": "Blocks the binding of interleukin-1 to interleukin-1 type I receptors. [GOC:ebc]"}
{"concept_id": "C1149395", "aliases": ["IL-1ra type II"], "types": ["T044"], "canonical_name": "interleukin-1 type II receptor antagonist activity", "definition": "Blocks the binding of interleukin-1 to interleukin-1 type II receptors. [GOC:ebc]"}
{"concept_id": "C1149396", "aliases": ["breathless binding", "FGFR1 binding"], "types": ["T044"], "canonical_name": "type 1 fibroblast growth factor receptor binding", "definition": "Binding to a type 1 fibroblast growth factor receptor (FGFR1). [GOC:ceb, GOC:fb_curators]"}
{"concept_id": "C1149397", "aliases": ["type 2 fibroblast growth factor receptor ligand", "heartless ligand"], "types": ["T044"], "canonical_name": "FGFR2 ligand"}
{"concept_id": "C1149399", "aliases": [], "types": ["T044"], "definition": "Binding to a ciliary neurotrophic factor receptor. [GOC:ai]", "canonical_name": "ciliary neurotrophic factor receptor binding"}
{"concept_id": "C1149400", "aliases": [], "types": ["T044"], "definition": "Binding to an erythropoietin receptor. [GOC:ai]", "canonical_name": "erythropoietin receptor binding"}
{"concept_id": "C1149401", "aliases": ["granulocyte macrophage colony-stimulating factor receptor binding", "GM-CSF receptor ligand", "GM-CSF receptor binding", "granulocyte macrophage colony stimulating factor receptor binding", "granulocyte macrophage colony-stimulating factor receptor ligand", "granulocyte macrophage colony-stimulating factor"], "types": ["T044"], "definition": "Binding to a granulocyte macrophage colony-stimulating factor receptor. [GOC:ai]", "canonical_name": "GMC-SF receptor ligand"}
{"concept_id": "C1149402", "aliases": ["granulocyte colony stimulating factor receptor binding", "granulocyte colony-stimulating factor receptor ligand", "G-CSF receptor ligand", "granulocyte colony-stimulating factor receptor binding"], "types": ["T044"], "definition": "Binding to a granulocyte colony-stimulating factor receptor. [GOC:ai]", "canonical_name": "GC-SF receptor ligand"}
{"concept_id": "C1149403", "aliases": [], "types": ["T044"], "definition": "Binding to a growth hormone receptor. [GOC:ai]", "canonical_name": "growth hormone receptor binding"}
{"concept_id": "C1149404", "aliases": [], "types": ["T044"], "canonical_name": "interferon-alpha/beta"}
{"concept_id": "C1149405", "aliases": ["interferon-gamma receptor ligand", "interferon-gamma"], "types": ["T044"], "definition": "Binding to an interferon-gamma receptor. [GOC:ai]", "canonical_name": "interferon-gamma receptor binding"}
{"concept_id": "C1149406", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-10 receptor. [GOC:ai]", "canonical_name": "interleukin-10 receptor binding"}
{"concept_id": "C1149407", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-11 receptor ligand"}
{"concept_id": "C1149408", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-12 receptor ligand"}
{"concept_id": "C1149409", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-13 receptor ligand"}
{"concept_id": "C1149411", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-15 receptor. [GOC:ai]", "canonical_name": "interleukin-15 receptor binding"}
{"concept_id": "C1149412", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-17 receptor. [GOC:ai]", "canonical_name": "interleukin-17 receptor binding"}
{"concept_id": "C1149413", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-17E receptor. [GOC:ai]", "canonical_name": "interleukin-17E receptor binding"}
{"concept_id": "C1149414", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-2 receptor. [GOC:ai]", "canonical_name": "interleukin-2 receptor binding"}
{"concept_id": "C1149415", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-21 receptor. [GOC:ai]", "canonical_name": "interleukin-21 receptor binding"}
{"concept_id": "C1149416", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-3 receptor. [GOC:ai]", "canonical_name": "interleukin-3 receptor binding"}
{"concept_id": "C1149417", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-4 receptor. [GOC:ai]", "canonical_name": "interleukin-4 receptor binding"}
{"concept_id": "C1149418", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-5 receptor. [GOC:ai]", "canonical_name": "interleukin-5 receptor binding"}
{"concept_id": "C1149419", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-6 receptor. [GOC:ai]", "canonical_name": "interleukin-6 receptor binding"}
{"concept_id": "C1149420", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-7 receptor. [GOC:ai]", "canonical_name": "interleukin-7 receptor binding"}
{"concept_id": "C1149421", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-9 receptor. [GOC:ai]", "canonical_name": "interleukin-9 receptor binding"}
{"concept_id": "C1149422", "aliases": [], "types": ["T044"], "definition": "Binding to an leukemia inhibitory factor receptor. [GOC:ai]", "canonical_name": "leukemia inhibitory factor receptor binding"}
{"concept_id": "C1149423", "aliases": [], "types": ["T044"], "canonical_name": "oncostatin-M"}
{"concept_id": "C1149424", "aliases": [], "types": ["T044"], "definition": "Binding to a prolactin receptor. [GOC:ai]", "canonical_name": "prolactin receptor binding"}
{"concept_id": "C1149425", "aliases": ["HGF receptor binding"], "types": ["T044"], "definition": "Binding to an hepatocyte growth factor receptor. [GOC:ai]", "canonical_name": "hepatocyte growth factor receptor binding"}
{"concept_id": "C1149426", "aliases": [], "types": ["T044"], "canonical_name": "high molecular weight B cell growth factor receptor ligand"}
{"concept_id": "C1149427", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-1 receptor. [GOC:go_curators]", "canonical_name": "interleukin-1 receptor binding"}
{"concept_id": "C1149428", "aliases": [], "types": ["T044"], "canonical_name": "IL-1 type I"}
{"concept_id": "C1149429", "aliases": [], "types": ["T044"], "canonical_name": "IL-1 type II"}
{"concept_id": "C1149430", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-16 receptor. [GOC:go_curators]", "canonical_name": "interleukin-16 receptor binding"}
{"concept_id": "C1149431", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-18 receptor. [GOC:go_curators]", "canonical_name": "interleukin-18 receptor binding"}
{"concept_id": "C1149432", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-19 receptor. [GOC:go_curators]", "canonical_name": "interleukin-19 receptor binding"}
{"concept_id": "C1149433", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-20 receptor. [GOC:go_curators]", "canonical_name": "interleukin-20 receptor binding"}
{"concept_id": "C1149434", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-22 receptor. [GOC:go_curators]", "canonical_name": "interleukin-22 receptor binding"}
{"concept_id": "C1149435", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-23 receptor. [GOC:go_curators]", "canonical_name": "interleukin-23 receptor binding"}
{"concept_id": "C1149436", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-24 receptor ligand"}
{"concept_id": "C1149437", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-25 receptor binding", "definition": "Binding to an interleukin-25 receptor. [GOC:go_curators]"}
{"concept_id": "C1149438", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-26 receptor binding", "definition": "Binding to an interleukin-26 receptor. [GOC:go_curators]"}
{"concept_id": "C1149439", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-27 receptor ligand"}
{"concept_id": "C1149440", "aliases": ["interleukin-8 receptor binding"], "types": ["T044"], "definition": "Binding to an interleukin-8 receptor. [GOC:go_curators]", "canonical_name": "IL-8"}
{"concept_id": "C1149441", "aliases": [], "types": ["T044"], "canonical_name": "macrophage colony-stimulating factor receptor ligand"}
{"concept_id": "C1149443", "aliases": [], "types": ["T044"], "definition": "Binding to a neurotrophin receptor. [GOC:ai]", "canonical_name": "neurotrophin receptor binding"}
{"concept_id": "C1149444", "aliases": ["nerve growth factor receptor binding"], "types": ["T044"], "definition": "Binding to a nerve growth factor receptor. [GOC:ai, PMID:15654015]", "canonical_name": "NGF receptor binding"}
{"concept_id": "C1149445", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin p75 receptor binding", "definition": "Binding to a neurotrophin p75 receptor. [GOC:ai]"}
{"concept_id": "C1149451", "aliases": ["stem cell factor receptor binding"], "types": ["T044"], "definition": "Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. [GOC:jl, PMID:10698217]", "canonical_name": "SCFR binding"}
{"concept_id": "C1149454", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone. [ISBN:0198506732, ISBN:0721662544]", "canonical_name": "activin"}
{"concept_id": "C1149455", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone. [ISBN:0198506732, ISBN:0721662544]", "canonical_name": "inhibin"}
{"concept_id": "C1149458", "aliases": [], "types": ["T044"], "canonical_name": "death receptor interacting protein activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149462", "aliases": ["G-protein-coupled receptor ligand"], "types": ["T044"], "canonical_name": "G protein coupled receptor ligand"}
{"concept_id": "C1149463", "aliases": ["APJ receptor binding"], "types": ["T044"], "canonical_name": "apelin receptor binding", "definition": "Binding to an apelin receptor. [GOC:mah, GOC:nln, GOC:vp, PMID:12787050]"}
{"concept_id": "C1149464", "aliases": [], "types": ["T044"], "canonical_name": "chemokine receptor ligand"}
{"concept_id": "C1149465", "aliases": ["beta chemokine receptor binding"], "types": ["T044"], "canonical_name": "CCR chemokine receptor binding", "definition": "Binding to a CCR chemokine receptor. [GOC:ai]"}
{"concept_id": "C1149466", "aliases": ["CXC chemokine receptor ligand", "alpha chemokine receptor ligand"], "types": ["T044"], "canonical_name": "C-X-C chemokine receptor ligand"}
{"concept_id": "C1149467", "aliases": [], "types": ["T044"], "canonical_name": "CXCR1 chemokine receptor binding", "definition": "Binding to a CXCR1 chemokine receptor. [GOC:ceb, PMID:11910892]"}
{"concept_id": "C1149468", "aliases": [], "types": ["T044"], "canonical_name": "CXCR2 chemokine receptor binding", "definition": "Binding to a CXCR2 chemokine receptor. [GOC:ceb, PMID:11910892]"}
{"concept_id": "C1149469", "aliases": ["fz binding"], "types": ["T044"], "canonical_name": "frizzled binding", "definition": "Binding to a frizzled (fz) receptor. [GOC:ceb]"}
{"concept_id": "C1149471", "aliases": ["orexin receptor binding"], "types": ["T044"], "canonical_name": "hypocretin receptor binding", "definition": "Binding to a hypocretin receptor. [GOC:ceb, PMID:11988773]"}
{"concept_id": "C1149472", "aliases": [], "types": ["T044"], "definition": "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]", "canonical_name": "growth factor activity"}
{"concept_id": "C1149474", "aliases": [], "types": ["T044"], "canonical_name": "imaginal disc growth factor"}
{"concept_id": "C1149475", "aliases": [], "types": ["T044"], "definition": "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. [GOC:dph, GOC:mah, ISBN:0198506732]", "canonical_name": "hormone activity"}
{"concept_id": "C1149476", "aliases": [], "types": ["T044"], "canonical_name": "digestive hormone activity", "definition": "The action characteristic of a hormone that takes part in the digestion process. [GOC:ai]"}
{"concept_id": "C1149477", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "peptide hormone"}
{"concept_id": "C1149480", "aliases": ["alpha-melanophore stimulating hormone activity"], "types": ["T044"], "canonical_name": "alpha-melanocyte stimulating hormone activity"}
{"concept_id": "C1149481", "aliases": ["cAMP generating peptide activity"], "types": ["T044"], "canonical_name": "cAMP generating peptide activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149482", "aliases": [], "types": ["T044"], "canonical_name": "diuretic hormone activity", "definition": "The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion. [GOC:mah, InterPro:IPR003621, PMID:8618894]"}
{"concept_id": "C1149484", "aliases": ["follicle stimulating hormone activity", "follitropin activity", "FSH activity"], "types": ["T044"], "definition": "The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis. [ISBN:0198547684]", "canonical_name": "follicle-stimulating hormone activity"}
{"concept_id": "C1149485", "aliases": ["GHRF activity", "GHRH activity"], "types": ["T044"], "definition": "The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland. [ISBN:0198506732]", "canonical_name": "growth hormone-releasing hormone activity"}
{"concept_id": "C1149487", "aliases": ["luteinizing hormone-releasing hormone activity", "LHRH activity", "gonadotrophin hormone-releasing hormone activity", "LH/FSH-RF", "GnRH activity", "luteinizing hormone-releasing factor activity", "luteinizing hormone/follicle-stimulating hormone releasing factor activity"], "types": ["T044"], "definition": "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. [ISBN:0198506732, PMID:11026571, Wikipedia:Gonadotropin-releasing_hormone]", "canonical_name": "gonadotropin hormone-releasing hormone activity"}
{"concept_id": "C1149488", "aliases": [], "types": ["T044"], "definition": "The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals. [GOC:mah, PMID:11416225, PMID:9792536]", "canonical_name": "melanin-concentrating hormone activity"}
{"concept_id": "C1149489", "aliases": [], "types": ["T044"], "canonical_name": "myoinhibitory hormone activity", "definition": "The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction. [GOC:mah, PMID:8902848]"}
{"concept_id": "C1149490", "aliases": [], "types": ["T044"], "canonical_name": "myostimulatory hormone activity", "definition": "The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction. [GOC:mah, PMID:12204246]"}
{"concept_id": "C1149491", "aliases": ["neurohormone"], "types": ["T044"], "definition": "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. [GOC:mah]", "canonical_name": "neuropeptide hormone activity"}
{"concept_id": "C1149493", "aliases": [], "types": ["T044"], "canonical_name": "ecdysiostatic hormone activity", "definition": "The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion. [DOI:10.1002/(SICI)1520-6327(1997)35:1, GOC:mah]"}
{"concept_id": "C1149494", "aliases": [], "types": ["T044"], "canonical_name": "ecdysis-triggering hormone activity", "definition": "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system. [GOC:mah, PMID:9020043]"}
{"concept_id": "C1149495", "aliases": [], "types": ["T044"], "definition": "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis. [GOC:mah, ISBN:0198506732]", "canonical_name": "eclosion hormone activity"}
{"concept_id": "C1149496", "aliases": ["neurohypophyseal hormone activity"], "types": ["T044"], "definition": "The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin. [GOC:mah, PMID:19243634]", "canonical_name": "neurohypophysial hormone activity"}
{"concept_id": "C1149497", "aliases": [], "types": ["T044"], "canonical_name": "prothoracicotrophic hormone activity", "definition": "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects. [GOC:mah, PMID:3301403]"}
{"concept_id": "C1149499", "aliases": ["pituitary adenylate cyclase activating polypeptide activity"], "types": ["T044"], "definition": "The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. [GOC:mah, PMID:19805477]", "canonical_name": "pituitary adenylyl cyclase activating polypeptide activity"}
{"concept_id": "C1149500", "aliases": ["thyrotropin releasing hormone activity", "thyrotropin-releasing hormone activity"], "types": ["T044"], "definition": "The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. [ISBN:0198506732]", "canonical_name": "TRH activity"}
{"concept_id": "C1149501", "aliases": [], "types": ["T044"], "canonical_name": "insulin receptor binding", "definition": "Binding to an insulin receptor. [GOC:ai]"}
{"concept_id": "C1149502", "aliases": ["IGF receptor binding"], "types": ["T044"], "definition": "Binding to an insulin-like growth factor receptor. [GOC:jl]", "canonical_name": "insulin-like growth factor receptor binding"}
{"concept_id": "C1149503", "aliases": [], "types": ["T044"], "definition": "Binding to an integrin. [GOC:ceb]", "canonical_name": "integrin binding"}
{"concept_id": "C1149504", "aliases": ["ICAM-3 receptor binding"], "types": ["T044"], "canonical_name": "intercellular adhesion molecule-3 receptor binding", "definition": "Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1. [GOC:ceb, PMID:11473836]"}
{"concept_id": "C1149505", "aliases": ["major histocompatibility complex binding"], "types": ["T044"], "canonical_name": "MHC protein binding", "definition": "Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]"}
{"concept_id": "C1149508", "aliases": ["NK cell lectin-like receptor binding"], "types": ["T044"], "canonical_name": "natural killer cell lectin-like receptor binding", "definition": "Binding to a lectin-like natural killer cell receptor. [GOC:ai]"}
{"concept_id": "C1149510", "aliases": ["Notch receptor binding", "N binding"], "types": ["T044"], "canonical_name": "Notch binding", "definition": "Binding to a Notch (N) protein, a surface receptor. [GOC:ceb]"}
{"concept_id": "C1149511", "aliases": [], "types": ["T044"], "definition": "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect. [ISBN:0198506732]", "canonical_name": "opioid peptide activity"}
{"concept_id": "C1149512", "aliases": ["ptc binding"], "types": ["T044"], "canonical_name": "patched binding", "definition": "Binding to a patched (ptc) protein, a receptor for hedgehog proteins. [GOC:ceb, PMID:11731473]"}
{"concept_id": "C1149513", "aliases": [], "types": ["T044"], "definition": "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant. [GOC:sgd_curators, ISBN:0198506732]", "canonical_name": "pheromone activity"}
{"concept_id": "C1149514", "aliases": [], "types": ["T044"], "canonical_name": "competence pheromone activity", "definition": "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence. [GOC:mah, PMID:7698645]"}
{"concept_id": "C1149515", "aliases": [], "types": ["T044"], "canonical_name": "punt ligand"}
{"concept_id": "C1149516", "aliases": [], "types": ["T044"], "canonical_name": "receptor agonist activity"}
{"concept_id": "C1149517", "aliases": [], "types": ["T044"], "canonical_name": "receptor antagonist activity", "definition": "The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. [GOC:ceb, ISBN:0198506732]"}
{"concept_id": "C1149518", "aliases": ["Ror binding"], "types": ["T044"], "canonical_name": "receptor tyrosine kinase-like orphan receptor binding", "definition": "Binding to a receptor tyrosine kinase-like orphan receptor (Ror). [GOC:ceb, GOC:vw]"}
{"concept_id": "C1149520", "aliases": [], "types": ["T044"], "canonical_name": "scavenger receptor ligand"}
{"concept_id": "C1149521", "aliases": [], "types": ["T044"], "canonical_name": "plexin binding"}
{"concept_id": "C1149522", "aliases": ["sevenless ligand"], "types": ["T044"], "canonical_name": "sev ligand"}
{"concept_id": "C1149523", "aliases": ["smo binding"], "types": ["T044"], "canonical_name": "smoothened binding", "definition": "Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals. [GOC:ceb, PMID:11731473]"}
{"concept_id": "C1149524", "aliases": ["sulphonylurea receptor binding"], "types": ["T044"], "canonical_name": "sulfonylurea receptor binding", "definition": "Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel. [GOC:ceb, PMID:11938023]"}
{"concept_id": "C1149525", "aliases": [], "types": ["T044"], "canonical_name": "thickveins binding"}
{"concept_id": "C1149526", "aliases": ["Toll receptor binding", "Tl binding"], "types": ["T044"], "canonical_name": "Toll binding", "definition": "Binding to a Toll protein, a transmembrane receptor. [GOC:ceb]"}
{"concept_id": "C1149527", "aliases": ["tor binding"], "types": ["T044"], "canonical_name": "torso binding", "definition": "Binding to a torso (tor) protein, a receptor tyrosine kinase. [GOC:ceb, PMID:2927509]"}
{"concept_id": "C1149528", "aliases": ["Wit binding"], "types": ["T044"], "canonical_name": "wishful thinking binding", "definition": "Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor. [GOC:ceb, PMID:11856529]"}
{"concept_id": "C1149529", "aliases": [], "types": ["T044"], "canonical_name": "selenium binding", "definition": "Binding to a selenium (Se) ion. [GOC:ai]"}
{"concept_id": "C1149530", "aliases": [], "types": ["T044"], "canonical_name": "steroid binding", "definition": "Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1149531", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol binding", "definition": "Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1149532", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Any substance that causes the lysis of red blood cells. [ISBN:0198506732]", "canonical_name": "hemolysin activity"}
{"concept_id": "C1149533", "aliases": [], "types": ["T044"], "canonical_name": "oxysterol binding", "definition": "Binding to oxysterol, an oxidized form of cholesterol. [GOC:curators]"}
{"concept_id": "C1149535", "aliases": ["calciferol binding"], "types": ["T044"], "canonical_name": "vitamin D binding", "definition": "Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]"}
{"concept_id": "C1149536", "aliases": [], "types": ["T044"], "canonical_name": "virion binding", "definition": "Binding to a virion, either by binding to components of the capsid or the viral envelope. [GOC:ai]"}
{"concept_id": "C1149537", "aliases": [], "types": ["T044"], "canonical_name": "vitamin binding", "definition": "Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]"}
{"concept_id": "C1149538", "aliases": ["vitamin B7 binding", "vitamin H binding"], "types": ["T044"], "canonical_name": "biotin binding", "definition": "Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1149539", "aliases": ["vitamin B9 binding", "folate binding", "vitamin M binding"], "types": ["T044"], "canonical_name": "folic acid binding", "definition": "Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1149540", "aliases": ["tocopherol binding"], "types": ["T044"], "canonical_name": "vitamin E binding", "definition": "Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. [ISBN:0721662544]"}
{"concept_id": "C1149541", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix. [ISBN:0198506732]", "canonical_name": "cell adhesion molecule activity"}
{"concept_id": "C1149543", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions. [ISBN:0198506732]", "canonical_name": "calcium-dependent cell adhesion molecule activity"}
{"concept_id": "C1149544", "aliases": ["calcium-independent cell adhesion molecule activity"], "types": ["T044"], "canonical_name": "calcium-independent cell adhesion molecule activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149545", "aliases": ["CAM binding"], "types": ["T044"], "canonical_name": "cell adhesion molecule binding", "definition": "Binding to a cell adhesion molecule. [GOC:ai]"}
{"concept_id": "C1149546", "aliases": [], "types": ["T044"], "canonical_name": "ICAM-3 receptor activity", "definition": "Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813]"}
{"concept_id": "C1149547", "aliases": [], "types": ["T044"], "definition": "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. [GOC:ai, PMID:2970671]", "canonical_name": "laminin receptor activity"}
{"concept_id": "C1149548", "aliases": [], "types": ["T044"], "canonical_name": "cell adhesion receptor regulator activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149549", "aliases": [], "types": ["T044"], "canonical_name": "cell adhesion receptor inhibitor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149550", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane. [EC:2.7.4.8]", "canonical_name": "membrane-associated guanylate kinase"}
{"concept_id": "C1149551", "aliases": ["viral-cell fusion molecule activity"], "types": ["T044"], "canonical_name": "viral-cell fusion molecule activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1149552", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function. [ISBN:0198547684]", "canonical_name": "chaperone activity"}
{"concept_id": "C1149553", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts. [EC:3.6.4.9, ISBN:0198547684]", "canonical_name": "chaperonin ATPase activity"}
{"concept_id": "C1149554", "aliases": ["co-chaperone activity"], "types": ["T044"], "canonical_name": "co-chaperone activity", "definition": "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity. [GOC:rb]"}
{"concept_id": "C1149555", "aliases": ["co-chaperonin activity"], "types": ["T044"], "canonical_name": "co-chaperonin activity", "definition": "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity. [GOC:rb]"}
{"concept_id": "C1149557", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein-specific chaperone activity", "definition": "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins. [GOC:jl, PMID:11337494]"}
{"concept_id": "C1149558", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones. [ISBN:0198547684]", "canonical_name": "heat shock protein activity"}
{"concept_id": "C1149559", "aliases": [], "types": ["T044"], "canonical_name": "histone-specific chaperone activity", "definition": "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function. [GOC:jl, PMID:7600578, PMID:9325046]"}
{"concept_id": "C1149561", "aliases": [], "types": ["T044"], "canonical_name": "metallochaperone activity", "definition": "Binding to and delivering metal ions to a target protein. [PMID:11739376]"}
{"concept_id": "C1149562", "aliases": [], "types": ["T044"], "definition": "Directly binding to and delivering copper ions to a target protein. [PMID:10790544, PMID:11739376]", "canonical_name": "copper chaperone activity"}
{"concept_id": "C1149563", "aliases": [], "types": ["T044"], "canonical_name": "superoxide dismutase copper chaperone activity", "definition": "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity. [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278]"}
{"concept_id": "C1149565", "aliases": [], "types": ["T044"], "canonical_name": "tubulin-specific chaperone activity", "definition": "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function. [GOC:jl, PMID:11847227]"}
{"concept_id": "C1149571", "aliases": [], "types": ["T044"], "canonical_name": "cytoskeletal regulator activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1149572", "aliases": [], "types": ["T044"], "canonical_name": "defense/immunity protein activity", "definition": "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease. [GOC:go_curators]"}
{"concept_id": "C1149574", "aliases": [], "types": ["T044"], "canonical_name": "antimicrobial peptide activity", "definition": "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells. [GOC:go_curators]"}
{"concept_id": "C1149575", "aliases": [], "types": ["T044"], "canonical_name": "antibacterial peptide activity", "definition": "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells. [GOC:go_curators]"}
{"concept_id": "C1149576", "aliases": [], "types": ["T044"], "canonical_name": "Gram-negative antibacterial peptide activity", "definition": "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells. [GOC:go_curators]"}
{"concept_id": "C1149577", "aliases": [], "types": ["T044"], "canonical_name": "Gram-positive antibacterial peptide activity", "definition": "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells. [GOC:go_curators]"}
{"concept_id": "C1149578", "aliases": [], "types": ["T044"], "canonical_name": "male-specific antibacterial peptide activity", "definition": "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males. [GOC:go_curators]"}
{"concept_id": "C1149582", "aliases": ["N,O-diacetylmuramidase activity", "peptidoglycan N-acetylmuramoylhydrolase activity", "L-7001", "1,4-N-acetylmuramidase activity", "lysozyme activity", "muramidase activity", "mucopeptide glucohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. [EC:3.2.1.17, PMID:22748813]", "canonical_name": "mucopeptide N-acetylmuramoylhydrolase activity"}
{"concept_id": "C1149584", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "blood coagulation factor activity"}
{"concept_id": "C1149594", "aliases": [], "types": ["T044"], "canonical_name": "cell surface antigen activity, host-interacting", "definition": "OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition. [GOC:mb]"}
{"concept_id": "C1149595", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Any of a set of activities involved in the complement cascade. [GOC:jl]", "canonical_name": "complement activity"}
{"concept_id": "C1149604", "aliases": ["high affinity Fc receptor activity"], "types": ["T044"], "canonical_name": "high affinity Fc receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:add]"}
{"concept_id": "C1149605", "aliases": ["low affinity Fc receptor activity"], "types": ["T044"], "canonical_name": "low affinity Fc receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:add]"}
{"concept_id": "C1149606", "aliases": ["1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity", "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity", "(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity", "(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity"], "types": ["T044"], "canonical_name": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity", "definition": "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. [EC:1.17.7.1, PMID:11752431]"}
{"concept_id": "C1149608", "aliases": [], "types": ["T044"], "canonical_name": "3,4-dihydroxy-2-butanone-4-phosphate synthase activity", "definition": "Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+). [EC:4.1.99.12, RHEA:18457]"}
{"concept_id": "C1149609", "aliases": ["4-amino-4-deoxychorismate lyase activity", "aminodeoxychorismate lyase activity", "ADC lyase activity", "4-amino-4-deoxychorismate pyruvate-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate. [EC:4.1.3.38, RHEA:16201]", "canonical_name": "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)"}
{"concept_id": "C1149614", "aliases": ["9-alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16-beta-ol-forming)"], "types": ["T044"], "canonical_name": "aphidicolan-16 beta-ol synthase activity", "definition": "Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate. [EC:4.2.3.42, PMID:12149019]"}
{"concept_id": "C1149615", "aliases": ["beta-alanyl-dopamine synthase activity", "NBAD transferase activity", "N-beta-alanyl dopamine synthetase activity"], "types": ["T044"], "canonical_name": "beta-alanyl amine synthase activity", "definition": "Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine. [GOC:bf, ISBN:0198506732, PMID:12900414, PMID:12957543, PMID:25229196]"}
{"concept_id": "C1149616", "aliases": [], "types": ["T044"], "definition": "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. [MetaCyc:RXN3O-227]", "canonical_name": "C-22 sterol desaturase activity"}
{"concept_id": "C1149618", "aliases": ["D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity"], "types": ["T044"], "canonical_name": "dihydroneopterin triphosphate 2'-epimerase activity", "definition": "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate. [MetaCyc:H2NTPEPIM-RXN]"}
{"concept_id": "C1149620", "aliases": [], "types": ["T044"], "canonical_name": "dihydropterin deaminase activity", "definition": "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3. [GOC:jl, PMID:19567870]"}
{"concept_id": "C1149621", "aliases": ["N-nitrosodimethylamine demethylase activity"], "types": ["T044"], "canonical_name": "dimethylnitrosamine demethylase activity", "definition": "Catalysis of the removal of a methyl group from N-nitrosodimethylamine. [GOC:mah]"}
{"concept_id": "C1149622", "aliases": ["diphosphoinositol-polyphosphate phosphohydrolase activity", "diphosphoinositol polyphosphate phosphohydrolase activity", "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity", "DIPP activity"], "types": ["T044"], "definition": "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. [EC:3.6.1.52]", "canonical_name": "diphosphoinositol-polyphosphate diphosphatase activity"}
{"concept_id": "C1149623", "aliases": [], "types": ["T044"], "definition": "Catalysis of the cleavage of branch points in branched glycogen polymers. [ISBN:0198506732]", "canonical_name": "glycogen debranching enzyme activity"}
{"concept_id": "C1149624", "aliases": ["oligo-1,4-1,4-glucantransferase activity", "4-alpha-glucanotransferase activity", "dextrin transglycosylase activity", "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity", "debranching enzyme maltodextrin glycosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. [EC:2.4.1.25]", "canonical_name": "amylomaltase activity"}
{"concept_id": "C1149625", "aliases": ["amylopectin-1,6-glucosidase activity", "dextrin-1,6-glucosidase activity", "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity", "amylopectin 1,6-glucosidase activity", "dextrin alpha-1,6-glucanohydrolase activity", "limit dextrinase activity", "amylo-alpha-1,6-glucosidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. [EC:3.2.1.33, ISBN:0198506732]", "canonical_name": "amylo-1,6-glucosidase activity"}
{"concept_id": "C1149626", "aliases": ["isoamylase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins. [EC:3.2.1.68]", "canonical_name": "glycogen alpha-1,6-glucanohydrolase activity"}
{"concept_id": "C1149627", "aliases": ["helicase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. [GOC:jl]", "canonical_name": "ATP-dependent helicase activity"}
{"concept_id": "C1149628", "aliases": [], "types": ["T045"], "canonical_name": "DNA helicase IV activity"}
{"concept_id": "C1149629", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. [PMID:9893272, RHEA:58196]", "canonical_name": "histone deacetylase activity"}
{"concept_id": "C1149630", "aliases": ["NAD-dependent histone deacetylase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone. [PMID:28450737]", "canonical_name": "SIR2"}
{"concept_id": "C1149631", "aliases": ["AcuC"], "types": ["T045"], "canonical_name": "NAD-independent histone deacetylase activity", "definition": "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone. [PMID:28450737]"}
{"concept_id": "C1149632", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732]", "canonical_name": "hydrolase activity"}
{"concept_id": "C1149633", "aliases": [], "types": ["T044"], "canonical_name": "GPI-anchor transamidase activity", "definition": "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. [ISBN:0471331309]"}
{"concept_id": "C1149634", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid anhydrides", "definition": "Catalysis of the hydrolysis of any acid anhydride. [GOC:jl]"}
{"concept_id": "C1149636", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "definition": "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. [GOC:jl]"}
{"concept_id": "C1149637", "aliases": ["acetylphosphatase activity", "acylphosphate phosphohydrolase activity", "acylphosphatase activity", "1,3-diphosphoglycerate phosphatase activity", "Ho 1-3", "acetic phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. [EC:3.6.1.7]", "canonical_name": "GP 1-3"}
{"concept_id": "C1149638", "aliases": [], "types": ["T044"], "canonical_name": "bis(5'-nucleosyl)-tetraphosphatase activity", "definition": "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides. [GOC:ai]"}
{"concept_id": "C1149639", "aliases": [], "types": ["T044"], "canonical_name": "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase"}
{"concept_id": "C1149640", "aliases": ["1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity", "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity", "adenosine tetraphosphate phosphodiesterase activity", "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity", "bis(5'-adenosyl)-tetraphosphatase activity", "bis(5'-adenosyl) tetraphosphatase activity", "diadenosine polyphosphate hydrolase activity", "dinucleosidetetraphosphatase (symmetrical) activity", "symmetrical diadenosine tetraphosphate hydrolase activity", "diadenosine 5',5'''-P1,P4-tetraphosphatase activity", "bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity", "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity", "diadenosine tetraphosphatase (symmetrical)", "diadenosinetetraphosphatase (symmetrical) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+). [EC:3.6.1.41, RHEA:24252]", "canonical_name": "diadenosine tetraphosphate hydrolase activity"}
{"concept_id": "C1149641", "aliases": ["2-hydroxy-(d)ATP pyrophosphatase activity", "2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity"], "types": ["T044"], "canonical_name": "dATP pyrophosphohydrolase activity", "definition": "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate. [GOC:pde, PMID:11139615]"}
{"concept_id": "C1149642", "aliases": ["dihydroneopterin monophosphate dephosphorylase activity"], "types": ["T044"], "canonical_name": "dihydroneopterin monophosphate phosphatase activity", "definition": "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate. [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN]"}
{"concept_id": "C1149643", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN]", "canonical_name": "dihydroneopterin triphosphate pyrophosphohydrolase activity"}
{"concept_id": "C1149644", "aliases": ["polyphosphate polyphosphohydrolase activity", "endopolyphosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. [EC:3.6.1.10]", "canonical_name": "polymetaphosphatase activity"}
{"concept_id": "C1149645", "aliases": ["exopolyphosphatase activity", "acid phosphoanhydride phosphohydrolase activity", "polyphosphate phosphohydrolase activity", "exopolypase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. [EC:3.6.1.11]", "canonical_name": "Gra-Pase activity"}
{"concept_id": "C1149646", "aliases": ["nucleoside-diphosphatase activity", "nucleoside diphosphate phosphatase activity", "nucleoside-diphosphate phosphohydrolase activity", "NDPase activity", "nucleoside diphosphate phosphohydrolase activity", "nucleoside 5'-diphosphatase activity", "inosine diphosphatase"], "types": ["T044"], "definition": "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. [EC:3.6.1.6]", "canonical_name": "nucleoside diphosphatase activity"}
{"concept_id": "C1149647", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate. [EC:3.6.1.5, MetaCyc:APYRASE-RXN]", "canonical_name": "apyrase activity"}
{"concept_id": "C1149648", "aliases": ["guanosine diphosphatase activity", "GDPase activity", "GDP phosphohydrolase activity", "guanosine-diphosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: GDP + H2O = GMP + phosphate. [EC:3.6.1.42, PMID:2989286, RHEA:22156]", "canonical_name": "guanosine 5'-diphosphatase activity"}
{"concept_id": "C1149649", "aliases": ["UDP phosphohydrolase activity", "UDPase activity", "uridine diphosphatase activity", "uridine-diphosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP + H2O = UMP + phosphate. [RHEA:64876]", "canonical_name": "uridine 5'-diphosphatase activity"}
{"concept_id": "C1149650", "aliases": ["NTPase activity", "unspecific diphosphate phosphohydrolase activity", "nucleoside-5-triphosphate phosphohydrolase activity", "nucleoside triphosphate phosphohydrolase activity", "nucleoside-triphosphatase activity", "nucleoside triphosphatase activity", "nucleoside 5-triphosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. [RHEA:23680]", "canonical_name": "nucleoside triphosphate hydrolase activity"}
{"concept_id": "C1149651", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]", "canonical_name": "pyrophosphatase activity"}
{"concept_id": "C1149652", "aliases": ["ADPsugar pyrophosphatase activity", "adenosine diphosphosugar pyrophosphatase activity", "ADP-sugar pyrophosphatase activity", "ADP-sugar sugarphosphohydrolase activity"], "types": ["T044"], "canonical_name": "ADP-sugar diphosphatase activity", "definition": "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate. [EC:3.6.1.21]"}
{"concept_id": "C1149653", "aliases": ["cytidine diphosphodiacylglycerol pyrophosphatase activity", "CDP diacylglycerol hydrolase activity", "CDP-diacylglycerol phosphatidylhydrolase activity", "CDP-diacylglycerol pyrophosphatase activity"], "types": ["T044"], "canonical_name": "CDP-diacylglycerol diphosphatase activity", "definition": "Catalysis of the reaction: CDP-diacylglycerol + H(2)O = a phosphatidate + CMP + 2 H(+). [EC:3.6.1.26, RHEA:15221]"}
{"concept_id": "C1149654", "aliases": ["dUTP nucleotidohydrolase activity", "deoxyuridine-triphosphatase activity", "desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "dUTP pyrophosphatase activity", "desoxyuridine 5'-triphosphatase activity", "dUTPase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate. [RHEA:10248]", "canonical_name": "dUTP diphosphatase activity"}
{"concept_id": "C1149655", "aliases": ["pppGpp 5'-phosphohydrolase activity", "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity", "guanosine pentaphosphate phosphohydrolase activity", "guanosine pentaphosphatase activity", "guanosine pentaphosphate phosphatase activity", "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity", "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity", "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate. [EC:3.6.1.40]", "canonical_name": "guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity"}
{"concept_id": "C1149656", "aliases": ["hydrogen-translocating pyrophosphatase activity", "diphosphate hydrolysis-driven proton transmembrane transporter activity", "PP(i) hydrolysis-driven proton transmembrane transporter activity", "pyrophosphate hydrolysis-driven proton transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transmembrane transport of one proton (H+), driven by the hydrolysis of pyrophosphate, and generating a proton motive force. [GOC:mtg_transport, ISBN:0815340729, Wikipedia:Proton-pumping_pyrophosphatase]", "canonical_name": "proton-translocating pyrophosphatase activity"}
{"concept_id": "C1149657", "aliases": ["diphosphate phosphohydrolase activity", "pyrophosphate phosphohydrolase activity", "inorganic pyrophosphatase activity"], "types": ["T044"], "canonical_name": "inorganic diphosphatase activity", "definition": "Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate. [EC:3.6.1.1, RHEA:24576]"}
{"concept_id": "C1149658", "aliases": ["NAD+ phosphohydrolase activity", "NAD pyrophosphatase activity", "nicotinamide adenine dinucleotide pyrophosphatase activity", "NAD(+) pyrophosphatase activity", "NAD+ diphosphatase activity", "NAD diphosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NAD+ + H2O = AMP + NMN. [RHEA:11800]", "canonical_name": "NAD+ pyrophosphatase activity"}
{"concept_id": "C1149659", "aliases": ["dinucleotide nucleotidohydrolase activity", "nucleotide pyrophosphatase activity", "nucleotide-sugar pyrophosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. [EC:3.6.1.9]", "canonical_name": "nucleotide diphosphatase activity"}
{"concept_id": "C1149660", "aliases": ["phosphoribosyl-ATP diphosphatase activity", "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity", "phosphoribosyl-ATP pyrophosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+). [EC:3.6.1.31, RHEA:22828]", "canonical_name": "phosphoribosyladenosine triphosphate pyrophosphatase activity"}
{"concept_id": "C1149661", "aliases": ["thiamine pyrophosphatase activity", "thiamin-pyrophosphatase activity", "TPPase activity", "thiamin pyrophosphatase activity", "thiaminpyrophosphatase activity"], "types": ["T044"], "canonical_name": "thiamine-diphosphatase activity", "definition": "Catalysis of the reaction: TPP + H2O = TMP + phosphate. [GOC:ai, RHEA:27998]"}
{"concept_id": "C1149662", "aliases": [], "types": ["T044"], "canonical_name": "UDP-2,3-diacylglucosamine hydrolase activity", "definition": "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP. [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770]"}
{"concept_id": "C1149663", "aliases": ["UDP-sugar sugarphosphohydrolase activity", "UDP-sugar hydrolase activity", "UDP-sugar pyrophosphatase activity", "nucleosidediphosphate-sugar diphosphatase activity", "UDP-sugar diphosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate. [EC:3.6.1.45]", "canonical_name": "nucleosidediphosphate-sugar pyrophosphatase activity"}
{"concept_id": "C1149664", "aliases": ["hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides"], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides", "definition": "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-. [GOC:ai]"}
{"concept_id": "C1149665", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1149666", "aliases": ["dynein ATPase activity"], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome. [EC:3.6.4.2]", "canonical_name": "dynein ATPase"}
{"concept_id": "C1149667", "aliases": ["ATP phosphohydrolase (tubulin-dimerizing)", "microtubule-severing ATPase activity"], "types": ["T044"], "canonical_name": "microtubule severing ATPase activity", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. [PMID:10910766]"}
{"concept_id": "C1149668", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction. [EC:3.6.4.1]", "canonical_name": "myosin ATPase activity"}
{"concept_id": "C1149669", "aliases": [], "types": ["T044"], "canonical_name": "non-chaperonin molecular chaperone ATPase activity", "definition": "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin. [EC:3.6.4.10]"}
{"concept_id": "C1149671", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle. [EC:3.6.4.7]", "canonical_name": "peroxisome-assembly ATPase activity"}
{"concept_id": "C1149674", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid carbon-carbon bonds", "definition": "Catalysis of the hydrolysis of any acid carbon-carbon bond. [GOC:jl]"}
{"concept_id": "C1149675", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances", "definition": "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. [GOC:ai]"}
{"concept_id": "C1149676", "aliases": ["(2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase activity", "2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity"], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity", "definition": "Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate. [RHEA:24789]"}
{"concept_id": "C1149677", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate. [UM-BBD_reactionID:r0458]"}
{"concept_id": "C1149678", "aliases": ["HOHPDA hydrolase activity", "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity", "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity"], "types": ["T044"], "canonical_name": "2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity", "definition": "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate. [EC:3.7.1.8]"}
{"concept_id": "C1149679", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate. [UM-BBD_reactionID:r0399]"}
{"concept_id": "C1149680", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate. [UM-BBD_reactionID:r0263]", "canonical_name": "2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity"}
{"concept_id": "C1149681", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate. [UM-BBD_reactionID:r0311]"}
{"concept_id": "C1149682", "aliases": ["HOD hydrolase activity", "2-hydroxymuconate-semialdehyde formylhydrolase activity", "HMSH", "2-hydroxymuconic semialdehyde hydrolase activity"], "types": ["T044"], "canonical_name": "2-hydroxymuconate-semialdehyde hydrolase activity", "definition": "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate. [EC:3.7.1.9]"}
{"concept_id": "C1149683", "aliases": [], "types": ["T044"], "canonical_name": "6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity", "definition": "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+. [UM-BBD_reactionID:r0444]"}
{"concept_id": "C1149684", "aliases": ["2,4-dioxopentanoate acetylhydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate. [EC:3.7.1.6, RHEA:16097]", "canonical_name": "acetylpyruvate hydrolase activity"}
{"concept_id": "C1149685", "aliases": [], "types": ["T044"], "canonical_name": "dihydrophloroglucinol hydrolase activity", "definition": "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate. [UM-BBD_reactionID:r0008]"}
{"concept_id": "C1149686", "aliases": ["fumarylacetoacetase activity", "fumarylacetoacetate hydrolase activity", "beta-diketonase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+). [EC:3.7.1.2, RHEA:10244]", "canonical_name": "4-fumarylacetoacetate fumarylhydrolase activity"}
{"concept_id": "C1149687", "aliases": ["kynurenine hydrolase activity", "L-kynurenine hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine. [EC:3.7.1.3]", "canonical_name": "kynureninase activity"}
{"concept_id": "C1149688", "aliases": ["oxalacetic hydrolase activity", "oxaloacetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate. [EC:3.7.1.1, RHEA:24432]", "canonical_name": "oxaloacetate acetylhydrolase activity"}
{"concept_id": "C1149689", "aliases": [], "types": ["T044"], "canonical_name": "trioxoheptanoate hydrolase activity", "definition": "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate. [MetaCyc:R306-RXN, UM-BBD_reactionID:r0094]"}
{"concept_id": "C1149690", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid carbon-phosphorus bonds", "definition": "Catalysis of the hydrolysis of any acid carbon-phosphorus bond. [GOC:jl]"}
{"concept_id": "C1149691", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid halide bonds", "definition": "Catalysis of the hydrolysis of any acid halide bond. [GOC:jl]"}
{"concept_id": "C1149692", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid halide bonds, in C-halide compounds", "definition": "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage. [ISBN:0198506732]"}
{"concept_id": "C1149693", "aliases": [], "types": ["T044"], "canonical_name": "1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity", "definition": "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol). [PMID:10464214]"}
{"concept_id": "C1149695", "aliases": ["halocarboxylic acid halidohydrolase activity", "2-haloalkanoic acid dehalogenase activity", "2-halocarboxylic acid dehalogenase II activity", "2-haloacid dehalogenase activity", "2-haloalkanoid acid halidohydrolase activity", "DL-2-haloacid dehalogenase activity", "DL-2 haloacid dehalogenase activity", "L-2-haloacid dehalogenase activity", "(S)-2-haloacid halidohydrolase activity", "(S)-2-haloacid dehalogenase activity", "L-DEX activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide. [EC:3.8.1.2]", "canonical_name": "2-haloacid halidohydrolase activity"}
{"concept_id": "C1149696", "aliases": ["4-chlorobenzoyl CoA chlorohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride. [EC:3.8.1.7]", "canonical_name": "4-chlorobenzoyl-CoA dehalogenase activity"}
{"concept_id": "C1149697", "aliases": ["atrazine chlorohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: atrazine + H(2)O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H(+). [EC:3.8.1.8, RHEA:11312]", "canonical_name": "AtzA"}
{"concept_id": "C1149698", "aliases": [], "types": ["T044"], "canonical_name": "cis-chloroacrylic acid dehalogenase activity", "definition": "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde. [UM-BBD_reactionID:r0688]"}
{"concept_id": "C1149699", "aliases": [], "types": ["T044"], "canonical_name": "deisopropyldeethylatrazine hydrolase activity", "definition": "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3. [UM-BBD_reactionID:0129]"}
{"concept_id": "C1149700", "aliases": [], "types": ["T044"], "canonical_name": "dichloroacetate halidohydrolase activity", "definition": "Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate. [UM-BBD_reactionID:r0383]"}
{"concept_id": "C1149701", "aliases": ["haloacetate halidohydrolase activity", "haloacetate dehalogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: haloacetate + H2O = glycolate + halide. [EC:3.8.1.3]", "canonical_name": "monohaloacetate dehalogenase activity"}
{"concept_id": "C1149703", "aliases": ["1-haloalkane halidohydrolase activity", "haloalkane dehalogenase activity", "1-haloalkane dehalogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide. [PMID:3624201, RHEA:19081]", "canonical_name": "1-chlorohexane halidohydrolase activity"}
{"concept_id": "C1149704", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine. [UM-BBD_ruleID:bt0330]", "canonical_name": "S-triazine hydrolase activity"}
{"concept_id": "C1149705", "aliases": ["iodothyronine outer ring monodeiodinase activity", "L-thyroxine iodohydrolase (reducing) activity", "thyroxine 5' deiodinase activity", "iodothyronine 5'-deiodinase activity", "diiodothyronine 5'-deiodinase activity", "outer ring-deiodinating pathway", "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)", "thyroxine deiodinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. [EC:1.21.99.4]", "canonical_name": "thyroxine 5'-deiodinase activity"}
{"concept_id": "C1149706", "aliases": [], "types": ["T044"], "canonical_name": "trans-chloroacrylic acid dehalogenase activity", "definition": "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde. [UM-BBD_reactionID:r0689]"}
{"concept_id": "C1149707", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid phosphorus-nitrogen bonds", "definition": "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond. [GOC:jl]"}
{"concept_id": "C1149708", "aliases": ["hydrolase activity, acting on acid sulphur-nitrogen bonds"], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid sulfur-nitrogen bonds", "definition": "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond. [GOC:jl]"}
{"concept_id": "C1149709", "aliases": ["cyclamate sulfohydrolase activity", "cyclamate sulfamatase activity", "cyclohexylsulfamate sulfamidase activity", "cyclamate sulphohydrolase activity", "cyclohexylsulfamate sulfohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cyclohexylsulfamate + H(2)O = cyclohexylamine + sulfate. [EC:3.10.1.2, RHEA:18481]", "canonical_name": "cyclamate sulfamidase activity"}
{"concept_id": "C1149710", "aliases": ["2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)", "sulphamidase activity", "sulfoglucosamine sulfamidase activity", "heparin sulfamidase activity", "N-sulphoglucosamine sulphohydrolase activity", "N-sulfo-D-glucosamine sulfohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate. [EC:3.10.1.1]", "canonical_name": "N-sulfoglucosamine sulfohydrolase activity"}
{"concept_id": "C1149711", "aliases": ["hydrolase activity, acting on acid sulphur-sulphur bonds"], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid sulfur-sulfur bonds", "definition": "Catalysis of the hydrolysis of any acid sulfur-sulfur bond. [GOC:jl]"}
{"concept_id": "C1149712", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "definition": "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. [GOC:jl]"}
{"concept_id": "C1149713", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides", "definition": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. [GOC:ai]"}
{"concept_id": "C1149714", "aliases": [], "types": ["T044"], "canonical_name": "3,5-dichlorophenylcarboximide hydrolase activity", "definition": "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate. [UM-BBD_reactionID:r0707]"}
{"concept_id": "C1149715", "aliases": ["5-oxoprolinase (ATP-hydrolysing)", "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)", "5-oxoprolinase activity", "pyroglutamase (ATP-hydrolysing)", "pyroglutamic hydrolase activity", "pyroglutamase activity", "oxoprolinase activity", "5-oxo-L-prolinase activity", "L-pyroglutamate hydrolase activity", "pyroglutamate hydrolase activity", "5-OPase activity", "5-oxoprolinase (ATP-hydrolyzing) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate. [EC:3.5.2.9, RHEA:10348]", "canonical_name": "pyroglutamase (ATP-hydrolyzing) activity"}
{"concept_id": "C1149716", "aliases": ["1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H(2)O = N-(6-aminohexanoyl)-6-aminohexanoate. [EC:3.5.2.12, RHEA:16225]", "canonical_name": "6-aminohexanoate-cyclic-dimer hydrolase activity"}
{"concept_id": "C1149717", "aliases": ["(S)-allantoin amidohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: allantoin + H2O = allantoate. [EC:3.5.2.5]", "canonical_name": "allantoinase activity"}
{"concept_id": "C1149718", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2. [EC:3.5.2.15]", "canonical_name": "cyanuric acid amidohydrolase activity"}
{"concept_id": "C1149719", "aliases": ["dihydroorotase activity", "carbamoylaspartic dehydrase activity", "(S)-dihydroorotate amidohydrolase activity", "DHOase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+). [EC:3.5.2.3, RHEA:24296]", "canonical_name": "dihydroorotate hydrolase activity"}
{"concept_id": "C1149720", "aliases": ["5,6-dihydropyrimidine amidohydrolase activity", "hydantoinase activity", "pyrimidine hydrase activity", "hydropyrimidine hydrase activity", "hydantoin peptidase activity", "dihydropyrimidinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. [EC:3.5.2.2]", "canonical_name": "D-hydantoinase activity"}
{"concept_id": "C1149721", "aliases": [], "types": ["T044"], "canonical_name": "epsilon-caprolactam lactamase activity", "definition": "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate. [UM-BBD_reactionID:r0448]"}
{"concept_id": "C1149722", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines", "definition": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. [ISBN:0198506732]"}
{"concept_id": "C1149723", "aliases": [], "types": ["T044"], "canonical_name": "cyclohydrolase activity", "definition": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring. [GOC:mah]"}
{"concept_id": "C1149724", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. [EC:3.5.4.16, EC:3.5.4.25, EC:3.5.4.29, GOC:curators]", "canonical_name": "GTP cyclohydrolase activity"}
{"concept_id": "C1149725", "aliases": ["GTP 7,8-8,9-dihydrolase activity", "dihydroneopterin triphosphate synthase activity", "guanosine triphosphate cyclohydrolase activity", "GTP 8-formylhydrolase activity", "guanosine triphosphate 8-deformylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. [EC:3.5.4.16]", "canonical_name": "GTP cyclohydrolase I activity"}
{"concept_id": "C1149726", "aliases": ["guanosine triphosphate cyclohydrolase II", "GTP cyclohydrolase II activity", "GTP 7,8-8,9-dihydrolase (diphosphate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+). [EC:3.5.4.25, RHEA:23704]", "canonical_name": "GTP-8-formylhydrolase activity"}
{"concept_id": "C1149727", "aliases": ["IMP synthetase activity", "inosinicase activity", "inosinate cyclohydrolase activity", "IMP 1,2-hydrolase (decyclizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. [EC:3.5.4.10]", "canonical_name": "IMP cyclohydrolase activity"}
{"concept_id": "C1149728", "aliases": ["methenyltetrahydrofolate cyclohydrolase activity", "citrovorum factor cyclodehydrase activity", "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)", "5,10-methenyl-THF cyclohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. [EC:3.5.4.9]", "canonical_name": "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)"}
{"concept_id": "C1149729", "aliases": ["5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)", "5,10-methenyltetrahydromethanopterin cyclohydrolase activity", "methenyl-H4MPT cyclohydrolase activity", "methenyl-H(4)MPT cyclohydrolase activity", "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+). [EC:3.5.4.27, RHEA:19053]", "canonical_name": "methenyltetrahydromethanopterin cyclohydrolase activity"}
{"concept_id": "C1149730", "aliases": ["1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity", "PRAMP-cyclohydrolase activity", "phosphoribosyl-AMP cyclohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. [EC:3.5.4.19, RHEA:20049]", "canonical_name": "phosphoribosyladenosine monophosphate cyclohydrolase activity"}
{"concept_id": "C1149731", "aliases": [], "types": ["T044"], "definition": "Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R). [GOC:jl]", "canonical_name": "deaminase activity"}
{"concept_id": "C1149732", "aliases": ["ADase activity", "adenase activity", "adenine aminohydrolase activity", "adenine deaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3. [EC:3.5.4.2]", "canonical_name": "adenine aminase activity"}
{"concept_id": "C1149733", "aliases": ["adenosine deaminase activity", "adenosine aminohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: adenosine + H2O = inosine + NH3. [EC:3.5.4.4]", "canonical_name": "adenosine deaminase reaction"}
{"concept_id": "C1149734", "aliases": ["tRNA-adenosine deaminase activity"], "types": ["T045"], "canonical_name": "tRNA-specific adenosine deaminase activity", "definition": "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule. [GOC:mah]"}
{"concept_id": "C1149735", "aliases": ["adenylate deaminase activity", "5-adenylate deaminase activity", "adenylate aminohydrolase activity", "AMP aminase activity", "adenosine 5-monophosphate deaminase activity", "AMP deaminase activity", "adenylic deaminase activity", "adenosine monophosphate deaminase activity", "adenylate deaminase reaction", "adenosine 5-phosphate aminohydrolase activity", "AMP aminohydrolase activity", "5-AMP deaminase activity", "5-adenylic acid deaminase activity", "adenyl deaminase activity", "adenylate desaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: AMP + H2O = IMP + NH3. [EC:3.5.4.6]", "canonical_name": "adenylic acid deaminase activity"}
{"concept_id": "C1149736", "aliases": ["cytidine deaminase activity", "cytosine nucleoside deaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cytidine + H2O = uridine + NH3. [EC:3.5.4.5]", "canonical_name": "cytidine aminohydrolase activity"}
{"concept_id": "C1149737", "aliases": ["cytosine aminohydrolase activity", "cytosine deaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cytosine + H2O = uracil + NH3. [EC:3.5.4.1]", "canonical_name": "isocytosine deaminase activity"}
{"concept_id": "C1149738", "aliases": ["deoxycytidine monophosphate deaminase activity", "dCMP deaminase activity", "deoxycytidylate deaminase activity", "dCMP aminohydrolase activity", "deoxycytidine-5'-phosphate deaminase activity", "deoxy-CMP-deaminase activity", "deoxycytidine-5'-monophosphate aminohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dCMP + H2O = dUMP + NH3. [EC:3.5.4.12]", "canonical_name": "deoxycytidylate aminohydrolase activity"}
{"concept_id": "C1149739", "aliases": ["dCTP aminohydrolase activity", "deoxycytidine triphosphate deaminase activity", "5-methyl-dCTP deaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dCTP + H2O = dUTP + NH3. [EC:3.5.4.13]", "canonical_name": "dCTP deaminase activity"}
{"concept_id": "C1149740", "aliases": ["2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity", "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity", "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+). [EC:3.5.4.26, RHEA:21868]", "canonical_name": "diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"}
{"concept_id": "C1149742", "aliases": ["guanase activity", "guanine aminase activity", "GAH activity", "guanine deaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: guanine + H2O = xanthine + NH3. [EC:3.5.4.3]", "canonical_name": "guanine aminohydrolase activity"}
{"concept_id": "C1149743", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "definition": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. [GOC:ai]"}
{"concept_id": "C1149744", "aliases": [], "types": ["T044"], "canonical_name": "(3,5-dichlorophenylurea)acetate amidohydrolase activity", "definition": "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine. [UM-BBD_reactionID:r0708]"}
{"concept_id": "C1149745", "aliases": ["6-aminohexanoic acid oligomer hydrolase activity", "6-aminohexanoate-dimer hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate. [EC:3.5.1.46]", "canonical_name": "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity"}
{"concept_id": "C1149746", "aliases": ["allophanate lyase activity", "allophanate hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+). [EC:3.5.1.54, RHEA:19029]", "canonical_name": "urea-1-carboxylate amidohydrolase activity"}
{"concept_id": "C1149747", "aliases": ["acylase activity", "acetamidase activity", "amidohydrolase activity", "N-acetylaminohydrolase activity", "fatty acylamidase activity", "acylamidase activity", "acylamide amidohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. [EC:3.5.1.4]", "canonical_name": "amidase activity"}
{"concept_id": "C1149748", "aliases": ["amido acid deacylase activity", "alpha-N-acylaminoacid hydrolase activity", "N-acyl-L-amino-acid amidohydrolase activity", "aminoacylase activity", "short acyl amidoacylase activity", "long acyl amidoacylase activity", "L-amino-acid acylase activity", "hippurase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. [EC:3.5.1.14]", "canonical_name": "L-aminoacylase activity"}
{"concept_id": "C1149749", "aliases": ["kynurenine formamidase activity", "formylase activity", "arylformamidase activity", "formylkynureninase activity", "formylkynurenine formamidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine. [EC:3.5.1.9]", "canonical_name": "aryl-formylamine amidohydrolase activity"}
{"concept_id": "C1149750", "aliases": ["asparaginase activity", "leunase activity", "elspar", "L-asparaginase activity", "L-asparagine amidohydrolase activity", "colaspase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. [EC:3.5.1.1]", "canonical_name": "alpha-asparaginase activity"}
{"concept_id": "C1149751", "aliases": ["4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity", "beta-aspartylglucosylamine amidohydrolase activity", "aspartylglucosaminidase activity", "glycosylasparaginase activity", "N-aspartyl-beta-glucosaminidase activity", "aspartylglucosylaminase activity", "aspartylglucosylamine deaspartylase activity", "N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity", "aspartylglycosylamine amidohydrolase activity", "aspartylglucosylaminidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+). [EC:3.5.1.26, RHEA:11544]", "canonical_name": "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity"}
{"concept_id": "C1149752", "aliases": [], "types": ["T044"], "canonical_name": "protein-N-terminal asparagine amidohydrolase activity", "definition": "Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein. [PMID:8910481]"}
{"concept_id": "C1149753", "aliases": ["acetyl-aspartic deaminase activity", "aspartoacylase activity", "N-acetylaspartate amidohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate. [EC:3.5.1.15]", "canonical_name": "N-acyl-L-aspartate amidohydrolase activity"}
{"concept_id": "C1149754", "aliases": ["N-carbamoyl-beta-alanine amidohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3. [EC:3.5.1.6]", "canonical_name": "beta-ureidopropionase activity"}
{"concept_id": "C1149755", "aliases": [], "types": ["T044"], "canonical_name": "biuret amidohydrolase activity", "definition": "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3. [EC:3.5.1.84]"}
{"concept_id": "C1149756", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid. [EC:3.5.1.23, GOC:pz]", "canonical_name": "ceramidase activity"}
{"concept_id": "C1149757", "aliases": ["galactosylceramidase activity", "cerebroside beta-galactosidase activity", "galactocerebroside-beta-D-galactosidase activity", "galactosylcerebrosidase activity", "galactocerebroside beta-galactosidase activity", "beta-galactosylceramidase activity", "ceramide galactosidase activity", "cerebroside galactosidase activity", "D-galactosyl-N-acylsphingosine galactohydrolase activity", "beta-galactocerebrosidase activity", "galcerase activity", "galactocerebrosidase activity", "galactosylceramide beta-galactosidase activity", "lactosylceramidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. [EC:3.2.1.46]", "canonical_name": "galactocerebroside galactosidase activity"}
{"concept_id": "C1149758", "aliases": ["D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity", "ceramidetrihexoside alpha-galactosidase activity", "ceramide trihexosidase activity", "trihexosyl ceramide galactosidase activity", "trihexosylceramide alpha-galactosidase activity", "galactosylgalactosylglucosylceramidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose. [EC:3.2.1.47]", "canonical_name": "ceramidetrihexosidase activity"}
{"concept_id": "C1149759", "aliases": ["GlcCer-beta-glucosidase activity", "beta-D-glucocerebrosidase activity", "glucocerebrosidase activity", "glucosylceramidase activity", "glucosphingosine glucosylhydrolase activity", "beta-glucosylceramidase activity", "glucosylsphingosine beta-glucosidase activity", "D-glucosyl-N-acylsphingosine glucohydrolase activity", "ceramide glucosidase activity", "glucosylsphingosine beta-D-glucosidase activity", "acid beta-glucosidase activity", "glucosylcerebrosidase activity", "beta-glucocerebrosidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. [EC:3.2.1.45]", "canonical_name": "psychosine hydrolase activity"}
{"concept_id": "C1149760", "aliases": ["glycosyl-N-acylsphingosine glycohydrolase activity", "glycosylceramidase activity", "glycosyl ceramide glycosylhydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. [PMID:10692580, PMID:9762914]", "canonical_name": "cerebrosidase activity"}
{"concept_id": "C1149761", "aliases": ["chitin deacetylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: chitin + H2O = chitosan + acetate. [EC:3.5.1.41]", "canonical_name": "chitin amidohydrolase activity"}
{"concept_id": "C1149762", "aliases": ["choloylglycine hydrolase activity", "glycocholase activity", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity", "bile salt hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine. [EC:3.5.1.24]", "canonical_name": "choloyltaurine hydrolase activity"}
{"concept_id": "C1149763", "aliases": [], "types": ["T044"], "canonical_name": "deacetylase activity", "definition": "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. [GOC:jl]"}
{"concept_id": "C1149764", "aliases": ["2-N-acetyl-L-ornithine amidohydrolase activity", "N2-acetyl-L-ornithine amidohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine. [EC:3.5.1.16]", "canonical_name": "acetylornithine deacetylase activity"}
{"concept_id": "C1149765", "aliases": ["N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity", "acetylaminodeoxyglucosephosphate acetylhydrolase activity", "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity", "N-acetylglucosamine-6-phosphate deacetylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate. [EC:3.5.1.25]", "canonical_name": "acetylglucosamine phosphate deacetylase activity"}
{"concept_id": "C1149766", "aliases": [], "types": ["T044"], "canonical_name": "UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity", "definition": "Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. [PMID:10026271]"}
{"concept_id": "C1149767", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid. [PMID:15952893]", "canonical_name": "fatty acid amide hydrolase activity"}
{"concept_id": "C1149768", "aliases": ["formamide amidohydrolase activity", "formamide hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+). [EC:3.5.1.49, RHEA:21948]", "canonical_name": "formamidase activity"}
{"concept_id": "C1149769", "aliases": ["N-formyl-L-methionine amidohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-formyl-L-methionine + H(2)O = L-methionine + formate. [EC:3.5.1.31, RHEA:17781]", "canonical_name": "formylmethionine deformylase activity"}
{"concept_id": "C1149770", "aliases": ["formyltetrahydrofolate hydrolase activity", "10-formyltetrahydrofolate amidohydrolase activity", "formyltetrahydrofolate deformylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+). [EC:3.5.1.10, RHEA:19833]", "canonical_name": "formyl-FH(4) hydrolase activity"}
{"concept_id": "C1149771", "aliases": ["glutaminase activity", "L-glutamine amidohydrolase activity", "glutamine aminohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. [EC:3.5.1.2]", "canonical_name": "L-glutaminase activity"}
{"concept_id": "C1149772", "aliases": ["cobyrinate a c-diamide synthase activity", "cobyrinate a,c-diamide synthase activity", "cobyrinate a c diamide synthase activity", "cobyrinate a,c diamide synthase activity", "cobyrinic acid a,c-diamide synthase activity"], "types": ["T044"], "definition": "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide. [PMID:2172209, RHEA:26289]", "canonical_name": "CobB"}
{"concept_id": "C1149773", "aliases": ["GSP amidase activity", "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity", "glutathionylspermidine amidohydrolase (spermidine-forming) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine. [EC:3.5.1.78]", "canonical_name": "glutathionylspermidine amidase activity"}
{"concept_id": "C1149774", "aliases": [], "types": ["T044"], "canonical_name": "iprodione amidohydrolase activity", "definition": "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate. [UM-BBD_reactionID:r0706]"}
{"concept_id": "C1149776", "aliases": ["N-acetylmuramyl-L-alanine amidase activity", "N-acetylmuramylalanine amidase activity", "acetylmuramoyl-alanine amidase activity", "N-acylmuramyl-L-alanine amidase activity", "N-acetylmuramoyl-L-alanine amidase activity", "acetylmuramyl-alanine amidase activity", "acetylmuramyl-L-alanine amidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. [EC:3.5.1.28, PMID:22748813]", "canonical_name": "N-acetylmuramic acid L-alanine amidase activity"}
{"concept_id": "C1149777", "aliases": ["nicotinamide amidase activity", "nicotinamide amidohydrolase activity", "NAMase activity", "YNDase activity", "nicotinamide deaminase activity", "nicotine deamidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3. [EC:3.5.1.19]", "canonical_name": "nicotinamidase activity"}
{"concept_id": "C1149778", "aliases": ["nicotinamide mononucleotide amidohydrolase activity", "NMN deamidase activity", "nicotinamide mononucleotide deamidase activity", "nicotinamide-nucleotide amidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3. [EC:3.5.1.42]", "canonical_name": "nicotinamide-D-ribonucleotide amidohydrolase activity"}
{"concept_id": "C1149779", "aliases": ["pantetheine hydrolase activity", "(R)-pantetheine amidohydrolase activity", "vanin-1", "pantetheinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine. [EC:3.5.1.92, RHEA:13445]", "canonical_name": "vanin"}
{"concept_id": "C1149780", "aliases": ["pantothenate amidohydrolase activity", "pantothenate hydrolase activity", "pantothenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine. [EC:3.5.1.22, RHEA:12448]", "canonical_name": "(R)-pantothenate amidohydrolase activity"}
{"concept_id": "C1149781", "aliases": ["penicillin amidohydrolase activity", "benzylpenicillin acylase activity", "semacylase activity", "penicillin amidase activity", "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity", "alpha-acylamino-beta-lactam acylhydrolase activity", "ampicillin acylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate. [EC:3.5.1.11]", "canonical_name": "penicillin acylase activity"}
{"concept_id": "C1149782", "aliases": ["PNGase", "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity", "peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. [EC:3.5.1.52]", "canonical_name": "PNGase F"}
{"concept_id": "C1149783", "aliases": ["N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity", "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity"], "types": ["T044"], "canonical_name": "succinyl-diaminopimelate desuccinylase activity", "definition": "Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate. [EC:3.5.1.18, RHEA:22608]"}
{"concept_id": "C1149784", "aliases": ["AstE", "N-succinyl-L-glutamate amidohydrolase activity", "N2-succinylglutamate desuccinylase activity", "SGDS"], "types": ["T044"], "canonical_name": "succinylglutamate desuccinylase activity", "definition": "Catalysis of the reaction: N-succinyl-L-glutamate + H(2)O = L-glutamate + succinate. [EC:3.5.1.96, RHEA:15169]"}
{"concept_id": "C1149785", "aliases": ["urease activity"], "types": ["T044"], "definition": "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. [EC:3.5.1.5, RHEA:20557]", "canonical_name": "urea amidohydrolase activity"}
{"concept_id": "C1149786", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines", "definition": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. [ISBN:0198506732]"}
{"concept_id": "C1149787", "aliases": [], "types": ["T044"], "canonical_name": "2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity", "definition": "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid. [UM-BBD_reactionID:r0122]"}
{"concept_id": "C1149788", "aliases": [], "types": ["T044"], "canonical_name": "2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity", "definition": "Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-. [UM-BBD_reactionID:r1414]"}
{"concept_id": "C1149789", "aliases": ["agmatinase activity", "agmatine ureohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: agmatine + H(2)O = putrescine + urea. [EC:3.5.3.11, RHEA:13929]", "canonical_name": "SpeB"}
{"concept_id": "C1149790", "aliases": ["allantoicase activity", "allantoate amidinohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea. [EC:3.5.3.4, RHEA:11016]", "canonical_name": "allantoine amidinohydrolase activity"}
{"concept_id": "C1149791", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3. [PMID:1991731]", "canonical_name": "ammelide aminohydrolase activity"}
{"concept_id": "C1149792", "aliases": [], "types": ["T044"], "canonical_name": "ammeline aminohydrolase activity", "definition": "Catalysis of the reaction: ammeline + H2O = ammelide + NH3. [PMID:1991731]"}
{"concept_id": "C1149793", "aliases": ["L-arginine amidinohydrolase activity", "arginine amidinase activity", "arginase activity", "canavanase activity", "L-arginase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea. [EC:3.5.3.1]", "canonical_name": "arginine transamidinase activity"}
{"concept_id": "C1149794", "aliases": ["arginine dihydrolase activity", "L-arginine deiminase activity", "citrulline iminase activity", "L-arginine iminohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3. [EC:3.5.3.6]", "canonical_name": "arginine deiminase activity"}
{"concept_id": "C1149795", "aliases": ["creatine amidinohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: creatine + H(2)O = sarcosine + urea. [EC:3.5.3.3, RHEA:22456]", "canonical_name": "creatinase activity"}
{"concept_id": "C1149796", "aliases": [], "types": ["T044"], "canonical_name": "deisopropylhydroxyatrazine aminohydrolase activity", "definition": "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine. [UM-BBD_reactionID:r0121]"}
{"concept_id": "C1149797", "aliases": ["N(G),N(G)-dimethylarginine dimethylaminohydrolase activity", "dimethylarginine dimethylaminohydrolase activity", "NG,NG-dimethylarginine dimethylaminohydrolase activity", "dimethylargininase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. [EC:3.5.3.18]", "canonical_name": "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity"}
{"concept_id": "C1149798", "aliases": ["peptidylarginine deiminase activity", "protein-L-arginine iminohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent. [PMID:27393304]", "canonical_name": "protein-arginine deiminase activity"}
{"concept_id": "C1149799", "aliases": ["SADH", "AruB", "arginine succinylhydrolase activity", "N2-succinylarginine dihydrolase activity", "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)", "N2-succinyl-L-arginine iminohydrolase (decarboxylating)", "succinylarginine dihydrolase activity", "AstB"], "types": ["T044"], "canonical_name": "N-succinylarginine dihydrolase activity", "definition": "Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H(2)O + 2 H(+) = N(2)-succinyl-L-ornithine + CO(2) + 2 NH(4)(+). [EC:3.5.3.23, RHEA:19533]"}
{"concept_id": "C1149800", "aliases": ["(S)-ureidoglycolate amidohydrolase (decarboxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+). [EC:3.5.1.116, RHEA:19809]", "canonical_name": "ureidoglycolate hydrolase activity"}
{"concept_id": "C1149801", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles", "definition": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN. [GOC:curators]"}
{"concept_id": "C1149802", "aliases": ["aliphatic nitrilase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3. [EC:3.5.5.7]", "canonical_name": "aliphatic nitrile aminohydrolase activity"}
{"concept_id": "C1149803", "aliases": ["bromoxynil-specific nitrilase activity", "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity"], "types": ["T044"], "canonical_name": "bromoxynil nitrilase activity", "definition": "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H(2)O = 3,5-dibromo-4-hydroxybenzoate + NH(4)(+). Involved in the bacterial degradation of the herbicide bromoxynil. [EC:3.5.5.6, RHEA:22100]"}
{"concept_id": "C1149804", "aliases": ["benzonitrilase activity", "nitrilase activity", "nitrile aminohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. [EC:3.5.5.1, GOC:kd]", "canonical_name": "acetonitrilase activity"}
{"concept_id": "C1149805", "aliases": ["thiocyanate aminohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + 2 H(+) + thiocyanate = carbonyl sulfide + NH(4)(+). [EC:3.5.5.8, RHEA:21464]", "canonical_name": "thiocyanate hydrolase activity"}
{"concept_id": "C1149806", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds", "definition": "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles. [GOC:ai]"}
{"concept_id": "C1149807", "aliases": ["hydroxyatrazine hydrolase activity", "AtzB", "hydroxyatrazine ethylaminohydrolase activity", "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity"], "types": ["T044"], "canonical_name": "hydroxydechloroatrazine ethylaminohydrolase activity", "definition": "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine. [EC:3.5.4.43]"}
{"concept_id": "C1149808", "aliases": ["AtzC"], "types": ["T044"], "canonical_name": "N-isopropylammelide isopropylaminohydrolase activity", "definition": "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine. [EC:3.5.4.42]"}
{"concept_id": "C1149809", "aliases": ["hydrolase activity, acting on carbon-sulphur bonds"], "types": ["T044"], "canonical_name": "hydrolase activity, acting on carbon-sulfur bonds", "definition": "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S. [GOC:jl]"}
{"concept_id": "C1149810", "aliases": ["UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity", "UDP-sulfoquinovose synthase activity", "UDPsulphoquinovose synthase activity", "sulfite:UDP-glucose sulfotransferase activity"], "types": ["T044"], "canonical_name": "UDPsulfoquinovose synthase activity", "definition": "Catalysis of the reaction: sulfite + UDP-D-glucose = H(2)O + UDP-6-sulfoquinovose. [EC:3.13.1.1, RHEA:13197]"}
{"concept_id": "C1149811", "aliases": ["hydrolase activity, acting on ester bonds"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of any ester bond. [GOC:jl]", "canonical_name": "esterase activity"}
{"concept_id": "C1149812", "aliases": [], "types": ["T044"], "canonical_name": "aspartyl esterase activity", "definition": "Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. [GOC:mah, UniProtKB-KW:KW-0063]"}
{"concept_id": "C1149813", "aliases": ["carboxylic acid esterase activity", "carboxyesterase activity", "carboxylic esterase activity", "carboxylesterase activity", "carboxylate esterase activity", "carboxylic ester hydrolase activity", "esterase B"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a carboxylic ester bond. [EC:3.1.1.-, EC:3.1.1.1, GOC:curators]", "canonical_name": "carboxyl ester hydrolase activity"}
{"concept_id": "C1149814", "aliases": [], "types": ["T044"], "canonical_name": "1-oxa-2-oxocycloheptane lactonase activity", "definition": "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate. [UM-BBD_reactionID:r0167]"}
{"concept_id": "C1149815", "aliases": ["alkylacetyl-GPC:acetylhydrolase activity", "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity", "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity", "2-acetyl-1-alkylglycerophosphocholine esterase activity"], "types": ["T044"], "canonical_name": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "definition": "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. [EC:3.1.1.47]"}
{"concept_id": "C1149816", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate. [UM-BBD_reactionID:r0419]", "canonical_name": "3,4-dihydrocoumarin hydrolase activity"}
{"concept_id": "C1149817", "aliases": ["6-PGL", "phosphogluconolactonase activity", "6-phosphogluconolactonase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+). [EC:3.1.1.31, RHEA:12556]", "canonical_name": "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity"}
{"concept_id": "C1149818", "aliases": ["acetylesterase activity", "acetic-ester acetylhydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. [EC:3.1.1.6]", "canonical_name": "acetic ester hydrolase activity"}
{"concept_id": "C1149819", "aliases": [], "types": ["T044"], "definition": "Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan. [PMID:10801485]", "canonical_name": "rhamnogalacturonan acetylesterase activity"}
{"concept_id": "C1149820", "aliases": ["N-acyl-O-acetylneuraminate O-acetylhydrolase activity", "N-acetylneuraminate acetyltransferase activity", "sialate 9(4)-O-acetylesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate. [EC:3.1.1.53, PMID:1991039]", "canonical_name": "sialate O-acetylesterase activity"}
{"concept_id": "C1149821", "aliases": [], "types": ["T044"], "definition": "Catalysis of the deacetylation of xylans and xylo-oligosaccharides. [EC:3.1.1.72]", "canonical_name": "acetylxylan esterase activity"}
{"concept_id": "C1149822", "aliases": ["aminoacyl-tRNA hydrolase reaction", "peptidyl-tRNA hydrolase activity", "aminoacyl-transfer ribonucleate hydrolase activity", "aminoacyl-tRNA aminoacylhydrolase activity", "N-substituted aminoacyl transfer RNA hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. [EC:3.1.1.29]", "canonical_name": "aminoacyl-tRNA hydrolase activity"}
{"concept_id": "C1149823", "aliases": [], "types": ["T044"], "canonical_name": "D-tyrosyl-tRNA hydrolase activity"}
{"concept_id": "C1149824", "aliases": ["arylesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. [EC:3.1.1.2]", "canonical_name": "aryl-ester hydrolase"}
{"concept_id": "C1149825", "aliases": [], "types": ["T044"], "canonical_name": "butyrolactone hydrolase activity", "definition": "Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate. [UM-BBD_reactionID:r0016]"}
{"concept_id": "C1149827", "aliases": ["true cholinesterase activity", "acetylcholine acetylhydrolase activity", "acetylcholinesterase activity", "AcCholE", "acetyl.beta-methylcholinesterase activity", "choline esterase I activity", "acetylcholine hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetylcholine + H2O = choline + acetate. [EC:3.1.1.7]", "canonical_name": "acetylthiocholinesterase activity"}
{"concept_id": "C1149828", "aliases": ["juvenile hormone analog esterase activity", "JH-esterase activity", "juvenile hormone carboxyesterase activity", "juvenile-hormone esterase activity", "JH esterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone. [PMID:11267890, RHEA:16393]", "canonical_name": "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity"}
{"concept_id": "C1149830", "aliases": ["maleylacetate enol-lactonase activity", "carboxymethylene butenolide hydrolase activity", "dienelactone hydrolase activity", "carboxymethylenebutenolidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate. [EC:3.1.1.45]", "canonical_name": "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity"}
{"concept_id": "C1149831", "aliases": ["butyrylcholinesterase activity", "BtChoEase activity", "anticholineesterase activity", "propionylcholinesterase activity", "benzoylcholinesterase activity", "non-specific cholinesterase activity", "pseudocholinesterase activity", "butyrylcholine esterase activity", "choline esterase II (unspecific) activity", "cholinesterase activity", "acylcholine acylhydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. [EC:3.1.1.8]", "canonical_name": "choline esterase activity"}
{"concept_id": "C1149832", "aliases": ["long-chain-fatty-acyl-ethyl-ester acylhydrolase activity", "FAEE synthase activity", "FAEES activity", "fatty-acyl-ethyl-ester synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol. [EC:3.1.1.67]", "canonical_name": "fatty-acyl ethyl ester synthase"}
{"concept_id": "C1149833", "aliases": ["ferulic acid esterase activity", "FAE-II", "FAE-III", "cinnAE", "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity", "hydroxycinnamoyl esterase activity", "cinnamoyl ester hydrolase activity", "FAEA", "feruloyl esterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide. [EC:3.1.1.73]", "canonical_name": "FAE-I"}
{"concept_id": "C1149834", "aliases": ["glucono-delta-lactonase activity", "gulonolactonase activity", "gluconolactonase activity", "D-glucono-1,5-lactone lactonohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. [EC:3.1.1.17]", "canonical_name": "aldonolactonase activity"}
{"concept_id": "C1149835", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group. [PMID:11640988]", "canonical_name": "lactonohydrolase activity"}
{"concept_id": "C1149836", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a lipid or phospholipid. [GOC:mah]", "canonical_name": "lipase activity"}
{"concept_id": "C1149837", "aliases": ["postheparin esterase activity", "diacylglycerol lipase activity", "postheparin lipase activity", "triacylglycero-protein acylhydrolase activity", "diacylglycerol hydrolase activity", "lipoprotein lipase activity", "lipemia-clearing factor"], "types": ["T044"], "definition": "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. [EC:3.1.1.34, GOC:bf]", "canonical_name": "diglyceride lipase activity"}
{"concept_id": "C1149838", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a glycerophospholipid. [ISBN:0198506732]", "canonical_name": "phospholipase activity"}
{"concept_id": "C1149839", "aliases": ["2-lysophosphatidylcholine acylhydrolase activity", "lysophosphatidylcholine hydrolase activity", "phospholipase B activity", "lecithinase B activity", "lysophosphatidase activity", "lysolecithinase activity", "lecitholipase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. [EC:3.1.1.5]", "canonical_name": "lysophospholipase activity"}
{"concept_id": "C1149840", "aliases": ["phospholipase A1 activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. [EC:3.1.1.32]", "canonical_name": "phosphatidylcholine 1-acylhydrolase activity"}
{"concept_id": "C1149841", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion. [EC:3.1.1.32]", "canonical_name": "phosphatidylserine-specific phospholipase A1 activity"}
{"concept_id": "C1149842", "aliases": ["phosphatidolipase activity", "phospholipase A2 activity", "lecithinase A activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801]", "canonical_name": "phosphatidylcholine 2-acylhydrolase activity"}
{"concept_id": "C1149843", "aliases": [], "types": ["T044"], "canonical_name": "cytosolic phospholipase A2 activity", "definition": "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. [EC:3.1.1.4]"}
{"concept_id": "C1149844", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent cytosolic phospholipase A2 activity", "definition": "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. [EC:3.1.1.4]"}
{"concept_id": "C1149845", "aliases": [], "types": ["T044"], "canonical_name": "calcium-independent cytosolic phospholipase A2 activity", "definition": "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. [EC:3.1.1.4]"}
{"concept_id": "C1149846", "aliases": [], "types": ["T044"], "canonical_name": "secreted phospholipase A2 activity", "definition": "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. [EC:3.1.1.4]"}
{"concept_id": "C1149847", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent secreted phospholipase A2 activity", "definition": "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. [EC:3.1.1.4]"}
{"concept_id": "C1149848", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. [EC:3.1.4.3, GOC:mah]", "canonical_name": "phospholipase C activity"}
{"concept_id": "C1149849", "aliases": ["phosphatidylinositol diacylglycerol-lyase activity", "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)", "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)", "1-phosphatidylinositol phosphodiesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol. [EC:4.6.1.13]", "canonical_name": "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)"}
{"concept_id": "C1149850", "aliases": ["PI-PLC activity", "phosphoinositidase C activity", "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity", "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity", "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity", "phosphoinositide phospholipase C activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol phospholipase C activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). [EC:3.1.4.11, RHEA:33179]"}
{"concept_id": "C1149851", "aliases": ["choline phosphatase activity", "phospholipase D activity", "phosphatidylcholine phosphatidohydrolase activity", "lipophosphodiesterase II activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. [EC:3.1.4.4]", "canonical_name": "lecithinase D activity"}
{"concept_id": "C1149852", "aliases": ["glycoprotein-phosphatidylinositol phosphatidohydrolase activity", "glycosylphosphatidylinositol phospholipase D activity", "phosphatidylinositol-specific phospholipase D activity", "glycoprotein phospholipase D activity", "phosphatidylinositol phospholipase D activity", "phosphatidylinositol-glycan-specific phospholipase D activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol. [EC:3.1.4.50]", "canonical_name": "GPI-PLD activity"}
{"concept_id": "C1149854", "aliases": ["GlcNAc-PI de-N-acetylase activity", "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity", "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity", "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity", "chitobiosylpyrophosphoryldolichol synthase activity", "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity", "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity", "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity", "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity", "N-acetylglucosaminylphosphatidylinositol deacetylase activity", "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity", "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity", "N-acetylglucosamine-1-phosphate transferase activity", "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity", "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity", "GlcNAc-1-P transferase activity", "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity", "acetylglucosaminylphosphatidylinositol deacetylase activity", "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. [EC:2.7.8.15]", "canonical_name": "GlcNAc-PI deacetylase activity"}
{"concept_id": "C1149855", "aliases": ["pectinoesterase activity", "pectinesterase activity", "pectin demethoxylase activity", "pectin methyl esterase activity", "pectin pectylhydrolase activity", "pectase activity", "pectin methoxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: pectin + n H2O = n methanol + pectate. [EC:3.1.1.11]", "canonical_name": "pectin methylesterase activity"}
{"concept_id": "C1149856", "aliases": ["protein-L-glutamate-O5-methyl-ester acylhydrolase activity", "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. [EC:3.1.1.61, RESID:AA0072]", "canonical_name": "protein-glutamate methylesterase activity"}
{"concept_id": "C1149857", "aliases": ["cholesterol ester hydrolase activity", "sterol ester hydrolase activity", "cholesteryl ester synthase activity", "steryl-ester acylhydrolase activity", "triterpenol esterase activity", "cholesteryl ester hydrolase activity", "cholesterase activity", "acylcholesterol lipase activity", "cholesteryl esterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. [EC:3.1.1.13]", "canonical_name": "sterol esterase activity"}
{"concept_id": "C1149858", "aliases": ["sulpholactone hydrolase activity"], "types": ["T044"], "canonical_name": "sulfolactone hydrolase activity", "definition": "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate. [UM-BBD_reactionID:r0583]"}
{"concept_id": "C1149859", "aliases": [], "types": ["T044"], "canonical_name": "diphosphoric monoester hydrolase activity", "definition": "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group. [GOC:ai]"}
{"concept_id": "C1149860", "aliases": ["guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity", "penta-phosphate guanosine-3'-diphosphohydrolase activity", "PpGpp-3'-pyrophosphohydrolase activity", "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity", "PpGpp phosphohydrolase activity", "penta-phosphate guanosine-3'-pyrophosphohydrolase activity", "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity", "(ppGpp)ase activity"], "types": ["T044"], "canonical_name": "guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity", "definition": "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate. [EC:3.1.7.2]"}
{"concept_id": "C1149861", "aliases": ["enterochelin esterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+. [MetaCyc:RXN0-1661, PMID:4565531]", "canonical_name": "enterobactin esterase activity"}
{"concept_id": "C1149862", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. [EC:3.1.4.-, GOC:curators]", "canonical_name": "phosphoric diester hydrolase activity"}
{"concept_id": "C1149864", "aliases": ["2',3'-cyclic nucleotide 3'-phosphodiesterase activity", "2',3'-cyclic nucleotide 3'-phosphohydrolase activity", "2':3'-cyclic nucleotide 3'-phosphodiesterase activity", "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity", "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity", "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity", "CNPase activity", "2':3'-CNMP-3'-ase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. [EC:3.1.4.37]", "canonical_name": "2',3'-cyclic AMP phosphodiesterase activity"}
{"concept_id": "C1149865", "aliases": ["nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity", "2',3'-cyclic nucleotidase activity", "2',3'-cyclic AMP 2'-phosphohydrolase activity", "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity", "2':3'-cyclic phosphodiesterase activity", "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity", "cyclic phosphodiesterase:3'-nucleotidase activity", "2',3'-cyclic-nucleotide 2'-phosphodiesterase activity", "2',3 '-cyclic AMP phosphodiesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate. [EC:3.1.4.16]", "canonical_name": "ribonucleoside 2',3'-cyclic phosphate diesterase activity"}
{"concept_id": "C1149866", "aliases": ["3',5'-nucleotide phosphodiesterase activity", "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity", "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity", "3',5' cyclic-nucleotide phosphodiesterase activity", "cyclic 3',5'-mononucleotide phosphodiesterase activity", "nucleoside-3',5-monophosphate phosphodiesterase activity", "cyclic nucleotide phosphodiesterase activity", "3',5'-cyclonucleotide phosphodiesterase activity", "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity", "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity", "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity", "PDE", "cyclic-nucleotide phosphodiesterase activity", "cyclic 3',5'-phosphodiesterase activity", "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity", "nucleoside 3',5'-cyclic phosphate diesterase activity", "cyclic 3',5'-nucleotide phosphodiesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. [GOC:mah]", "canonical_name": "3',5'-cyclic-nucleotide phosphodiesterase activity"}
{"concept_id": "C1149867", "aliases": [], "types": ["T044"], "canonical_name": "calmodulin-dependent cyclic-nucleotide phosphodiesterase activity"}
{"concept_id": "C1149868", "aliases": ["cAMP-specific phosphodiesterase activity", "cyclic AMP-specific phosphodiesterase activity", "3',5'-cAMP-specific phosphodiesterase activity", "3',5'-cyclic-AMP-specific phosphodiesterase activity", "3',5' cAMP-specific phosphodiesterase activity", "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity"], "types": ["T044"], "canonical_name": "3',5'-cyclic-AMP phosphodiesterase activity", "definition": "Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. [GOC:ai, RHEA:25277]"}
{"concept_id": "C1149869", "aliases": [], "types": ["T044"], "canonical_name": "cGMP-inhibited cyclic-nucleotide phosphodiesterase activity", "definition": "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP. [GOC:mah]"}
{"concept_id": "C1149871", "aliases": [], "types": ["T044"], "canonical_name": "cGMP-stimulated cyclic-nucleotide phosphodiesterase activity", "definition": "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. [GOC:mah]"}
{"concept_id": "C1149872", "aliases": [], "types": ["T044"], "canonical_name": "photoreceptor cyclic-nucleotide phosphodiesterase activity", "definition": "Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide. [GOC:curators]"}
{"concept_id": "C1149873", "aliases": ["glycerophosphodiester glycerophosphohydrolase activity", "glycerophosphoryl diester phosphodiesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. [EC:3.1.4.46]", "canonical_name": "glycerophosphodiester phosphodiesterase activity"}
{"concept_id": "C1149875", "aliases": ["sphingomyelinase activity", "sphingomyelin cholinephosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). [EC:3.1.4.12, RHEA:19253]", "canonical_name": "sphingomyelin phosphodiesterase activity"}
{"concept_id": "C1149879", "aliases": ["ACP hydrolyase activity", "[acyl-carrier protein] phosphodiesterase activity", "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity", "acyl-carrier-protein phosphodiesterase activity", "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity", "[acyl-carrier-protein] phosphodiesterase activity", "AcpH", "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein. [EC:3.1.4.14]", "canonical_name": "ACP phosphodiesterase activity"}
{"concept_id": "C1149880", "aliases": ["phosphatase", "phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. [GOC:curators, GOC:pg]", "canonical_name": "phosphoric monoester hydrolase activity"}
{"concept_id": "C1149881", "aliases": ["2-deoxy-D-glucose-6-phosphate phosphohydrolase activity", "2-deoxyglucose-6-phosphate phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate. [EC:3.1.3.68]", "canonical_name": "2-deoxyglucose-6-phosphatase activity"}
{"concept_id": "C1149882", "aliases": ["3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate. [EC:3.1.3.45, RHEA:11500]", "canonical_name": "3-deoxy-manno-octulosonate-8-phosphatase activity"}
{"concept_id": "C1149883", "aliases": ["3-phytase activity", "phytate 3-phosphatase activity", "myo-inositol-hexaphosphate 3-phosphohydrolase activity", "1-phytase activity", "phytate 1-phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate. [EC:3.1.3.8]", "canonical_name": "myo-inositol-hexakisphosphate 3-phosphohydrolase activity"}
{"concept_id": "C1149884", "aliases": [], "types": ["T044"], "canonical_name": "4-nitrophenylphosphatase activity"}
{"concept_id": "C1149885", "aliases": ["myo-inositol-hexakisphosphate 6-phosphohydrolase activity", "6-phytase activity", "phytate 6-phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate. [EC:3.1.3.26]", "canonical_name": "4-phytase activity"}
{"concept_id": "C1149886", "aliases": ["orthophosphoric-monoester phosphohydrolase (acid optimum)", "acid phosphohydrolase activity", "acid nucleoside diphosphate phosphatase activity", "acid phosphomonoester hydrolase activity", "phosphate-monoester phosphohydrolase (acid optimum)", "acid phosphatase activity", "acid phosphomonoesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. [EC:3.1.3.2]", "canonical_name": "acid monophosphatase activity"}
{"concept_id": "C1149887", "aliases": ["thiamine phosphate phosphatase activity", "thiamin monophosphate phosphatase", "thiamin phosphate phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate. [PMID:197075]", "canonical_name": "ThMPase"}
{"concept_id": "C1149888", "aliases": ["alkaline phosphomonoesterase activity", "orthophosphoric-monoester phosphohydrolase (alkaline optimum)", "alkaline phosphatase activity", "alkaline phosphohydrolase activity", "alkaline phenyl phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [EC:3.1.3.1]", "canonical_name": "phosphate-monoester phosphohydrolase (alkaline optimum)"}
{"concept_id": "C1149890", "aliases": ["aryldialkylphosphatase activity", "paraoxon esterase activity", "esterase B1", "esterase E4", "organophosphate esterase activity", "organophosphate hydrolase activity", "phosphotriesterase activity", "aryltriphosphate dialkylphosphohydrolase activity", "aryltriphosphatase activity", "organophosphorus hydrolase activity", "OPH", "pirimiphos-methyloxon esterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. [EC:3.1.8.1]", "canonical_name": "organophosphorus acid anhydrase activity"}
{"concept_id": "C1149891", "aliases": ["2,3-bisphosphoglycerate phosphatase activity", "2,3-diphosphoglyceric acid phosphatase activity", "2,3-diphosphoglycerate phosphatase activity", "bisphosphoglycerate phosphatase activity", "glycerate-2,3-diphosphate phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate. [EC:3.1.3.80, GOC:mah, PMID:18413611]", "canonical_name": "diphosphoglycerate phosphatase activity"}
{"concept_id": "C1149892", "aliases": ["fructose-2,6-bisphosphatase activity", "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity", "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. [EC:3.1.3.46]", "canonical_name": "fructose-2,6-bisphosphate 2-phosphatase activity"}
{"concept_id": "C1149893", "aliases": ["fructose diphosphate phosphatase activity", "fructose bisphosphate phosphatase activity", "FBPase activity", "fructose 1,6-diphosphatase activity", "D-fructose 1,6-diphosphatase activity", "fructose 1,6-bisphosphatase activity", "fructose diphosphatase activity", "D-fructose-1,6-bisphosphate phosphatase activity", "fructose-1,6-bisphosphatase activity", "hexose bisphosphatase activity", "D-fructose-1,6-bisphosphate 1-phosphohydrolase activity", "fructose 1,6-diphosphate phosphatase activity", "fructose 1,6-bisphosphate 1-phosphatase activity", "hexose diphosphatase activity", "fructose 1,6-bisphosphate phosphatase activity", "hexosediphosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. [EC:3.1.3.11]", "canonical_name": "fructose-bisphosphatase activity"}
{"concept_id": "C1149894", "aliases": ["D-glucose-1-phosphate phosphohydrolase activity", "glucose-1-phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate. [EC:3.1.3.10]", "canonical_name": "alpha-D-glucose-1-phosphate phosphohydrolase activity"}
{"concept_id": "C1149895", "aliases": ["D-glucose-6-phosphate phosphohydrolase activity", "glucose 6-phosphate phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate. [EC:3.1.3.9, RHEA:16689]", "canonical_name": "glucose-6-phosphatase activity"}
{"concept_id": "C1149896", "aliases": ["glycerol-3-phosphate phosphatase activity", "glycerol-1-phosphatase activity", "glycerol 3-phosphatase activity", "alpha-glycerophosphatase activity", "glycerol-3-phosphatase activity", "glycerol-1-phosphate phosphohydrolase activity", "alpha-glycerol phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate. [EC:3.1.3.21]", "canonical_name": "glycerol 3-phosphate phosphohydrolase activity"}
{"concept_id": "C1149897", "aliases": ["L-histidinol-phosphate phosphohydrolase activity", "histidinolphosphate phosphatase activity", "histidinol phosphate phosphatase activity", "L-histidinol phosphate phosphatase activity", "histidinolphosphatase activity", "histidinol-phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate. [EC:3.1.3.15, RHEA:14465]", "canonical_name": "HPpase activity"}
{"concept_id": "C1149899", "aliases": [], "types": ["T044"], "canonical_name": "inositol bisphosphate phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate. [GOC:hb]"}
{"concept_id": "C1149900", "aliases": ["1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity", "inositol-polyphosphate 1-phosphatase activity", "inositol polyphosphate 1-phosphatase activity"], "types": ["T044"], "canonical_name": "inositol-1,4-bisphosphate 1-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. [EC:3.1.3.57, GOC:hb]"}
{"concept_id": "C1149901", "aliases": ["1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. [EC:3.1.3.66, GOC:hb]"}
{"concept_id": "C1149902", "aliases": [], "types": ["T044"], "canonical_name": "inositol-4,5-bisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. [GOC:mah]"}
{"concept_id": "C1149903", "aliases": ["IP(3) phosphatase activity", "IP3 phosphatase activity", "inositol-1,4,5-trisphosphate phosphatase"], "types": ["T044"], "canonical_name": "inositol trisphosphate phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. [GOC:bf]"}
{"concept_id": "C1149904", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,3,4-trisphosphate 4-phosphatase activity", "definition": "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate. [GOC:ai]"}
{"concept_id": "C1149905", "aliases": ["inositol 1,4,5-trisphosphate phosphatase activity", "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity", "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity", "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity", "inositol trisphosphate phosphomonoesterase activity", "inositol polyphosphate-5-phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [EC:3.1.3.56]", "canonical_name": "inositol-polyphosphate 5-phosphatase activity"}
{"concept_id": "C1149906", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity", "definition": "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate. [GOC:ai]"}
{"concept_id": "C1149908", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity", "definition": "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. [GOC:ai]"}
{"concept_id": "C1149909", "aliases": ["inositol-1(or 4)-monophosphatase activity"], "types": ["T044"], "canonical_name": "inositol-1(or 4)-monophosphatase activity"}
{"concept_id": "C1149910", "aliases": ["MMAC1", "PtdIns(3,4,5)P3 3-phosphatase activity", "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity", "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity", "PI(3,4,5)P3 3-phosphatase activity", "PI(3)P 3-phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. [EC:3.1.3.67]", "canonical_name": "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity"}
{"concept_id": "C1149911", "aliases": ["inositol-polyphosphate 3-phosphatase activity", "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity", "inositol 1,3-bisphosphate phosphatase activity", "inositol-1,3-bisphosphate 3-phosphatase activity", "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity", "phosphatidylinositol-3-phosphatase activity", "inositol-1,4,-bisphosphate 3-phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. [EC:3.1.3.64]", "canonical_name": "phosphatidyl-3-phosphate 3-phosphohydrolase activity"}
{"concept_id": "C1149913", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-bisphosphatase activity"}
{"concept_id": "C1149914", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate. [MetaCyc:NADPPHOSPHAT-RXN]", "canonical_name": "NADP phosphatase activity"}
{"concept_id": "C1149915", "aliases": ["nucleotide-specific phosphatase activity", "nucleotide phosphohydrolase activity", "deoxyribonucleoside-activated nucleotidase (DAN)", "NSP I", "NSP II", "acid nucleotidase activity", "nucleotidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. [RHEA:22140]", "canonical_name": "deoxyinosine-activated nucleotidase (DIAN)"}
{"concept_id": "C1149916", "aliases": ["3'-phosphoadenylylsulfate 3'-phosphatase activity", "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity", "3'(2'),5' bisphosphate nucleotidase activity", "3'(2'),5'-bisphosphate nucleotidase activity", "DPNPase activity", "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. [EC:3.1.3.7]", "canonical_name": "phosphoadenylate 3'-nucleotidase activity"}
{"concept_id": "C1149917", "aliases": ["3'-ribonucleotidase activity", "3'-phosphatase activity", "3' nucleotidase activity", "3'-nucleotidase activity", "3'-mononucleotidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. [EC:3.1.3.6]", "canonical_name": "3'-ribonucleotide phosphohydrolase activity"}
{"concept_id": "C1149918", "aliases": ["5'-mononucleotidase activity", "5'-nucleotidase activity", "AMPase", "UMPase", "5'-AMPase", "AMP phosphohydrolase", "5' nucleotidase activity", "5'-AMP nucleotidase"], "types": ["T044"], "definition": "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. [EC:3.1.3.5]", "canonical_name": "5'-ribonucleotide phosphohydrolase activity"}
{"concept_id": "C1149919", "aliases": ["IMP-GMP specific 5'-nucleotidase activity"], "types": ["T044"], "canonical_name": "IMP-GMP specific 5'-nucleotidase activity", "definition": "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile. [EC:3.1.3.5, GOC:krc]"}
{"concept_id": "C1149920", "aliases": ["acid phosphatidyl phosphatase activity", "phosphatic acid phosphatase activity", "phosphatidic acid phosphatase activity", "phosphatic acid phosphohydrolase activity", "phosphatidate phosphohydrolase activity", "3-sn-phosphatidate phosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. [EC:3.1.3.4, GOC:pr]", "canonical_name": "phosphatidate phosphatase activity"}
{"concept_id": "C1149921", "aliases": ["PGP phosphatase activity", "phosphatidylglycerophosphatase activity", "phosphatidylglycerol phosphate phosphatase activity", "phosphatidylglycerol phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate. [PMID:4292860]", "canonical_name": "phosphatidylglycerophosphate phosphohydrolase activity"}
{"concept_id": "C1149922", "aliases": ["phosphoglycollate phosphatase activity", "2-phosphoglycolate phosphatase activity", "P-glycolate phosphatase activity", "phosphoglycolate hydrolase activity", "phosphoglycolate phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate. [EC:3.1.3.18, RHEA:14369]", "canonical_name": "2-phosphoglycolate phosphohydrolase activity"}
{"concept_id": "C1149925", "aliases": ["5'-polynucleotidase activity", "polynucleotide 5'-triphosphatase activity", "polynucleotide 5'-phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. [EC:3.1.3.33]", "canonical_name": "polynucleotide 5'-phosphohydrolase activity"}
{"concept_id": "C1149927", "aliases": ["phosphoprotein phosphatase activity", "protein phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. [ISBN:0198547684]", "canonical_name": "phosphoprotein phosphohydrolase activity"}
{"concept_id": "C1149929", "aliases": ["serine/threonine specific protein phosphatase activity"], "types": ["T044"], "canonical_name": "protein serine/threonine phosphatase activity", "definition": "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. [GOC:bf]"}
{"concept_id": "C1149930", "aliases": ["calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity"], "types": ["T044"], "definition": "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. [EC:3.1.3.16, GOC:mah]", "canonical_name": "calcium-dependent protein serine/threonine phosphatase activity"}
{"concept_id": "C1149932", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent protein serine/threonine phosphatase regulator activity", "definition": "Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. [GOC:ai]"}
{"concept_id": "C1149933", "aliases": ["RNA polymerase II CTD heptapeptide repeat phosphatase activity", "CTD phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate. [PMID:22622228]", "canonical_name": "RNA polymerase II carboxy-terminal domain phosphatase activity"}
{"concept_id": "C1149936", "aliases": ["myosin phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. [EC:3.1.3.16]", "canonical_name": "myosin phosphatase, intrinsic catalyst activity"}
{"concept_id": "C1149938", "aliases": [], "types": ["T044"], "canonical_name": "myosin phosphatase, intrinsic regulator activity"}
{"concept_id": "C1149939", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 1 regulator activity"}
{"concept_id": "C1149940", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 2A, intrinsic regulator activity"}
{"concept_id": "C1149942", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 4 regulator activity"}
{"concept_id": "C1149944", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 2A activity"}
{"concept_id": "C1149946", "aliases": ["calcineurin activity", "protein phosphatase type 2B activity"], "types": ["T044"], "canonical_name": "calcineurin"}
{"concept_id": "C1149948", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 2C activity"}
{"concept_id": "C1149951", "aliases": ["pyruvate dehydrogenase (lipoamide) phosphatase activity", "phosphopyruvate dehydrogenase phosphatase activity", "pyruvate dehydrogenase phosphatase activity", "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity", "pyruvate dehydrogenase (lipoamide)-phosphatase activity", "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "[pyruvate dehydrogenase (lipoamide)] phosphatase activity", "definition": "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate. [EC:3.1.3.43]"}
{"concept_id": "C1149953", "aliases": [], "types": ["T044"], "canonical_name": "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity"}
{"concept_id": "C1149955", "aliases": ["PTP-phosphatase activity", "tyrosine O-phosphate phosphatase activity", "PTPase activity", "protein tyrosine phosphatase activity", "phosphotyrosine histone phosphatase activity", "PPT-phosphatase activity", "phosphotyrosylprotein phosphatase activity", "tyrosylprotein phosphatase activity", "protein-tyrosine-phosphatase activity", "protein-tyrosine-phosphate phosphohydrolase activity", "phosphotyrosine protein phosphatase activity", "protein phosphotyrosine phosphatase activity", "phosphoprotein phosphatase (phosphotyrosine) activity", "[phosphotyrosine]protein phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]", "canonical_name": "phosphotyrosine phosphatase activity"}
{"concept_id": "C1149956", "aliases": [], "types": ["T044"], "canonical_name": "non-membrane spanning protein tyrosine phosphatase activity", "definition": "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48]"}
{"concept_id": "C1149957", "aliases": [], "types": ["T044"], "canonical_name": "prenylated protein tyrosine phosphatase activity", "definition": "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. [EC:3.1.3.48]"}
{"concept_id": "C1149959", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor protein tyrosine phosphatase activity", "definition": "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]"}
{"concept_id": "C1149960", "aliases": [], "types": ["T044"], "canonical_name": "dual-specificity protein phosphatase"}
{"concept_id": "C1149961", "aliases": [], "types": ["T044"], "canonical_name": "JUN kinase phosphatase activity", "definition": "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate. [GOC:mah]"}
{"concept_id": "C1149962", "aliases": ["MAPK phosphatase activity"], "types": ["T044"], "canonical_name": "MAP kinase phosphatase activity", "definition": "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. [GOC:mah, PMID:12184814, PMID:17208316]"}
{"concept_id": "C1149963", "aliases": [], "types": ["T044"], "canonical_name": "protein tyrosine/threonine phosphatase activity", "definition": "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]"}
{"concept_id": "C1149964", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor protein phosphatase activity", "definition": "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. [GOC:hjd]"}
{"concept_id": "C1149965", "aliases": ["SPPase activity", "sphingosine-1-phosphate phosphohydrolase activity", "sphingosine-1-phosphate phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. [GOC:jl, PMID:8663293]", "canonical_name": "SPP phosphatase activity"}
{"concept_id": "C1149966", "aliases": ["trehalose 6-phosphate phosphatase activity", "trehalose 6-phosphatase activity", "trehalose-6-phosphate phosphohydrolase activity", "trehalose phosphatase activity"], "types": ["T044"], "canonical_name": "trehalose-phosphatase activity", "definition": "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate. [EC:3.1.3.12]"}
{"concept_id": "C1149967", "aliases": [], "types": ["T044"], "canonical_name": "phosphoric triester hydrolase activity", "definition": "Catalysis of the hydrolysis of a phosphoric triester. [EC:3.1.8.-, GOC:curators]"}
{"concept_id": "C1149968", "aliases": ["sulfuric ester hydrolase activity", "sulphuric ester hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. [GOC:ai]", "canonical_name": "sulfatase activity"}
{"concept_id": "C1149969", "aliases": ["alkyl sulphatase activity"], "types": ["T044"], "canonical_name": "alkyl sulfatase activity", "definition": "Catalysis of the reaction: dodecyl sulfate + H2O = sulfate + H+ + 1-dodecanol. [UM-BBD_reactionID:r0602]"}
{"concept_id": "C1149970", "aliases": ["phenolsulfatase activity", "arylsulfatase activity", "estrogen sulfatase activity", "aryl-sulfate sulphohydrolase activity", "aryl-sulfate sulfohydrolase activity", "arylsulfohydrolase activity", "phenylsulfatase activity", "aryl-sulphate sulphohydrolase activity", "nitrocatechol sulfatase activity", "4-methylumbelliferyl sulfatase activity", "arylsulphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. [EC:3.1.6.1]", "canonical_name": "p-nitrophenyl sulfatase activity"}
{"concept_id": "C1149971", "aliases": ["cerebroside sulfate sulfatase activity", "arylsulfatase A activity", "cerebroside-sulphatase activity", "cerebroside-3-sulfate 3-sulfohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate. [EC:3.1.6.8]", "canonical_name": "cerebroside-sulfatase activity"}
{"concept_id": "C1149972", "aliases": ["glucurono-2-sulfatase activity", "glucuronate-2-sulfatase activity", "chondro-2-sulfatase activity", "glucuronate-2-sulphatase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. [EC:3.1.6.18]", "canonical_name": "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity"}
{"concept_id": "C1149973", "aliases": ["L-iduronate-2-sulfate 2-sulfohydrolase activity", "L-iduronosulfatase activity", "sulfo-L-iduronate sulfatase activity", "idurono-2-sulfatase activity", "iduronate sulfatase activity", "iduronate sulfate sulfatase activity", "L-idurono sulfate sulfatase activity", "2-sulfo-L-iduronate 2-sulfatase activity", "iduronide-2-sulfate sulfatase activity", "sulfoiduronate sulfohydrolase activity", "L-iduronate 2-sulfate sulfatase activity", "iduronate-2-sulfatase activity", "iduronate-2-sulfate sulfatase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. [EC:3.1.6.13]", "canonical_name": "iduronate-2-sulphatase activity"}
{"concept_id": "C1149974", "aliases": ["acetylgalactosamine 4-sulfatase activity", "N-acetylgalactosamine-4-sulphatase activity", "arylsulfatase B", "N-acetylgalactosamine 4-sulfate sulfohydrolase activity", "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. [EC:3.1.6.12]", "canonical_name": "N-acetylgalactosamine-4-sulfatase activity"}
{"concept_id": "C1149975", "aliases": ["N-acetylglucosamine-6-sulfatase activity", "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity", "acetylglucosamine 6-sulfatase activity", "N-acetylglucosamine 6-sulfate sulfatase activity", "glucosamine-6-sulfatase activity", "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity", "O,N-disulfate O-sulfohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. [EC:3.1.6.14]", "canonical_name": "N-acetylglucosamine-6-sulphatase activity"}
{"concept_id": "C1149976", "aliases": ["steryl-sulfatase activity", "sterol sulfatase activity", "steryl-sulfate sulfohydrolase activity", "phenolic steroid sulfatase activity", "steroid sulfatase activity", "3-beta-hydroxysteroid sulfate sulfatase activity", "steryl-sulphatase activity", "arylsulfatase C activity", "pregnenolone sulfatase activity", "steroid 3-sulfatase activity", "dehydroepiandrosterone sulfate sulfatase activity", "steroid sulfate sulfohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. [EC:3.1.6.2]", "canonical_name": "dehydroepiandrosterone sulfatase activity"}
{"concept_id": "C1149977", "aliases": ["thiolesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. [EC:3.1.2.-]", "canonical_name": "thiolester hydrolase activity"}
{"concept_id": "C1149978", "aliases": ["2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity", "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity", "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity", "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity", "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity", "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity", "HPBS desulfinase activity", "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity", "gene dszB-encoded hydrolase activity", "HBPSi desulfinase activity", "DszB", "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity"], "types": ["T044"], "canonical_name": "2'-hydroxybiphenyl-2-sulfinate desulfinase activity", "definition": "Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H(2)O = biphenyl-2-ol + sulfite. [EC:3.13.1.3, RHEA:12945]"}
{"concept_id": "C1149979", "aliases": [], "types": ["T044"], "canonical_name": "CoA hydrolase activity", "definition": "Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. [GOC:ai]"}
{"concept_id": "C1149980", "aliases": [], "types": ["T044"], "canonical_name": "2-ketocyclohexane-1-carboxyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA. [UM-BBD_reactionID:r0193]"}
{"concept_id": "C1149981", "aliases": ["3-hydroxyisobutyryl-CoA hydrolase activity", "3-hydroxy-isobutyryl CoA hydrolase activity", "HIB CoA deacylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. [EC:3.1.2.4]", "canonical_name": "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity"}
{"concept_id": "C1149982", "aliases": ["4-hydroxybenzoyl-CoA hydrolase activity", "4-hydroxybenzoyl-CoA thioesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA + H(+). [EC:3.1.2.23, RHEA:11948]", "canonical_name": "4-hydroxybenzoyl-CoA thiolesterase activity"}
{"concept_id": "C1149983", "aliases": [], "types": ["T044"], "canonical_name": "6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA. [UM-BBD_reactionID:r0206]"}
{"concept_id": "C1149984", "aliases": ["acetyl coenzyme A hydrolase activity", "acetyl-CoA acylase activity", "acetyl-CoA hydrolase activity", "acetyl coenzyme A acylase activity", "acetyl-CoA thiol esterase activity", "acetyl-CoA deacylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). [EC:3.1.2.1, RHEA:20289]", "canonical_name": "acetyl coenzyme A deacylase activity"}
{"concept_id": "C1149986", "aliases": [], "types": ["T044"], "canonical_name": "acyl-CoA thioesterase I activity"}
{"concept_id": "C1149987", "aliases": [], "types": ["T044"], "canonical_name": "acyl-CoA thioesterase II activity"}
{"concept_id": "C1149989", "aliases": ["palmitoyl-CoA deacylase activity", "palmitoyl coenzyme A hydrolase activity", "palmityl-CoA deacylase activity", "palmitoyl-CoA hydrolase activity", "palmitoyl thioesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. [EC:3.1.2.2]", "canonical_name": "palmityl thioesterase activity"}
{"concept_id": "C1149990", "aliases": ["succinyl coenzyme A hydrolase activity", "succinyl-CoA hydrolase activity", "succinyl coenzyme A deacylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate. [EC:3.1.2.3, RHEA:11516]", "canonical_name": "succinyl-CoA acylase activity"}
{"concept_id": "C1149991", "aliases": ["S-(2-hydroxyacyl)glutathione hydrolase activity", "hydroxyacylglutathione hydrolase activity", "S-2-hydroxylacylglutathione hydrolase activity", "acetoacetylglutathione hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. [EC:3.1.2.6]", "canonical_name": "glyoxalase II activity"}
{"concept_id": "C1149992", "aliases": ["palmitoyl-protein thiolesterase activity", "palmitoyl-(protein) hydrolase activity", "palmitoyl-protein hydrolase activity", "palmitoyl-protein thioesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. [EC:3.1.2.22]", "canonical_name": "palmitoyl-[protein] hydrolase"}
{"concept_id": "C1149993", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+). [EC:3.1.2.12, RHEA:14961]", "canonical_name": "S-formylglutathione hydrolase activity"}
{"concept_id": "C1149997", "aliases": ["tetradecanoyl-ACP hydrolase activity", "myristoyl-ACP hydrolase activity", "myristoyl-[acyl-carrier protein] hydrolase activity", "tetradecanoyl-[acyl-carrier-protein] hydrolase activity"], "types": ["T044"], "canonical_name": "myristoyl-[acyl-carrier-protein] hydrolase activity", "definition": "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate. [EC:3.1.2.14, MetaCyc:RXN-10727]"}
{"concept_id": "C1149998", "aliases": ["oleoyl-[acyl-carrier-protein] hydrolase activity", "oleoyl-[acyl-carrier protein] hydrolase activity", "oleoyl-acyl-carrier-protein hydrolase", "oleoyl-ACP hydrolase activity", "oleoyl-ACP thioesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate. [EC:3.1.2.14]", "canonical_name": "oleoyl-acyl carrier protein thioesterase activity"}
{"concept_id": "C1149999", "aliases": ["palmitoyl-ACP hydrolase activity", "palmitoyl-[acyl-carrier protein] hydrolase activity"], "types": ["T044"], "canonical_name": "palmitoyl-[acyl-carrier-protein] hydrolase activity", "definition": "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate. [EC:3.1.2.14, MetaCyc:RXN-9549]"}
{"concept_id": "C1150000", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. [GOC:ai]", "canonical_name": "triphosphoric monoester hydrolase activity"}
{"concept_id": "C1150001", "aliases": ["deoxy-GTPase activity", "deoxyguanosine 5-triphosphate triphosphohydrolase activity", "deoxyguanosinetriphosphate triphosphohydrolase activity", "dGTP triphosphohydrolase activity", "deoxyguanosine triphosphate triphosphohydrolase activity", "deoxyguanosine triphosphatase activity"], "types": ["T044"], "canonical_name": "dGTPase activity", "definition": "Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate. [EC:3.1.5.1, RHEA:15193]"}
{"concept_id": "C1150002", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on ether bonds", "definition": "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. [GOC:ai, GOC:jl]"}
{"concept_id": "C1150003", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of an ether bond, -O-. [EC:3.3.2.-, GOC:ai]", "canonical_name": "ether hydrolase activity"}
{"concept_id": "C1150004", "aliases": ["leukotriene A4 hydrolase activity", "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity", "LTA4 hydrolase activity", "LTA-4 hydrolase activity", "LTA4H", "leukotriene-A4 hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4). [EC:3.3.2.6, RHEA:22324]", "canonical_name": "leukotriene A(4) hydrolase activity"}
{"concept_id": "C1150005", "aliases": ["10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity", "soluble epoxide hydrolase activity", "trans-stilbene oxide hydrolase activity", "cytosolic epoxide hydrolase activity", "sEH", "epoxide hydrolase activity", "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an epoxide + H2O = a glycol. [EC:3.3.2.10]", "canonical_name": "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity"}
{"concept_id": "C1150006", "aliases": [], "types": ["T044"], "canonical_name": "epoxide hydrolase A activity", "definition": "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol. [UM-BBD_enzymeID:e0049]"}
{"concept_id": "C1150007", "aliases": [], "types": ["T044"], "canonical_name": "epoxide hydrolase B activity", "definition": "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers. [UM-BBD_enzymeID:e0051]"}
{"concept_id": "C1150008", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol. [GOC:mah, PMID:8396141]", "canonical_name": "juvenile hormone epoxide hydrolase activity"}
{"concept_id": "C1150009", "aliases": ["limonene-1,2-epoxide hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. [EC:3.3.2.8]", "canonical_name": "limonene oxide hydrolase activity"}
{"concept_id": "C1150010", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene-epoxide hydrolase activity", "definition": "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene. [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536]"}
{"concept_id": "C1150011", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene-1,2-epoxide hydrolase activity", "definition": "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene. [UM-BBD_reactionID:r0536]"}
{"concept_id": "C1150012", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene-3,4-epoxide hydrolase activity", "definition": "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene. [UM-BBD_reactionID:r0535]"}
{"concept_id": "C1150013", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene-9,10-epoxide hydrolase activity", "definition": "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene. [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560]"}
{"concept_id": "C1150014", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity", "definition": "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene. [UM-BBD_reactionID:r0560]"}
{"concept_id": "C1150015", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity", "definition": "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene. [UM-BBD_reactionID:r0496]"}
{"concept_id": "C1150016", "aliases": ["isochorismate pyruvate-hydrolase activity", "2,3 dihydro-2,3 dihydroxybenzoate synthase activity", "2,3-dihydro-2,3-dihydroxybenzoate synthase activity", "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity", "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate. [EC:3.3.2.1, RHEA:11112]", "canonical_name": "isochorismatase activity"}
{"concept_id": "C1150017", "aliases": ["trialkylsulfonium hydrolase activity", "trialkylsulphonium hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a thioether bond, -S-. [EC:3.3.1.-, GOC:ai]", "canonical_name": "thioether hydrolase activity"}
{"concept_id": "C1150018", "aliases": ["S-adenosylhomocysteine synthase activity", "AdoHcyase activity", "S-adenosyl-L-homocysteine hydrolase activity", "adenosylhomocysteinase activity", "S-adenosylhomocysteinase activity", "adenosylhomocysteine hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. [EC:3.3.1.1]", "canonical_name": "SAHase activity"}
{"concept_id": "C1150020", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, hydrolyzing N-glycosyl compounds", "definition": "Catalysis of the hydrolysis of any N-glycosyl bond. [GOC:jl]"}
{"concept_id": "C1150021", "aliases": ["S-adenosylhomocysteine nucleosidase activity", "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity", "5'-methyladenosine nucleosidase activity", "AdoHcy/MTA nucleosidase activity", "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine. [EC:3.2.2.9]", "canonical_name": "adenosylhomocysteine nucleosidase activity"}
{"concept_id": "C1150022", "aliases": ["ADP-ribose-L-arginine cleavage enzyme activity", "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity", "protein ADP-ribosylarginine hydrolase activity", "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity", "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity", "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity", "ADP-ribosylarginine hydrolase activity", "ADPribosylarginine hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose. [EC:3.2.2.19]", "canonical_name": "ADP-ribose-L-arginine cleaving enzyme activity"}
{"concept_id": "C1150023", "aliases": ["AMP phosphoribohydrolase activity", "adenylate nucleosidase activity", "AMP nucleosidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: AMP + H(2)O = D-ribose 5-phosphate + adenine. [EC:3.2.2.4, RHEA:20129]", "canonical_name": "adenosine monophosphate nucleosidase activity"}
{"concept_id": "C1150024", "aliases": ["MTA nucleosidase activity", "methylthioadenosine methylthioribohydrolase activity", "MeSAdo nucleosidase activity", "5'-methylthioadenosine nucleosidase activity", "S-methyl-5'-thioadenosine adeninehyrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose. [EC:3.2.2.16]", "canonical_name": "methylthioadenosine nucleosidase activity"}
{"concept_id": "C1150025", "aliases": ["NAD+ nucleosidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]", "canonical_name": "NAD nucleosidase activity"}
{"concept_id": "C1150026", "aliases": ["nicotinamide-nucleotide phosphoribohydrolase activity", "NMN nucleosidase activity", "nicotinamide mononucleotidase activity", "NMNGhase activity", "NMN glycohydrolase activity", "nicotinamide mononucleotide nucleosidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + nicotinamide mononucleotide = D-ribose 5-phosphate + H(+) + nicotinamide. [EC:3.2.2.14, RHEA:23140]", "canonical_name": "NMNase activity"}
{"concept_id": "C1150027", "aliases": ["purine beta-ribosidase activity", "purine ribonucleosidase activity", "N-ribosyl purine ribohydrolase activity", "N-D-ribosylpurine ribohydrolase activity", "ribonucleoside hydrolase activity", "purine nucleosidase reaction", "purine nucleoside hydrolase activity", "purine nucleosidase activity", "purine-specific nucleoside N-ribohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose. [EC:3.2.2.1]", "canonical_name": "purine-nucleoside ribohydrolase activity"}
{"concept_id": "C1150028", "aliases": [], "types": ["T045"], "definition": "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule. [GOC:mah]", "canonical_name": "RNA glycosylase activity"}
{"concept_id": "C1150029", "aliases": ["rRNA N-glycosylase activity", "RNA N-glycosidase activity", "ricin", "rRNA N-glycohydrolase activity", "rRNA N-glycosidase activity"], "types": ["T045"], "definition": "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species. [EC:3.2.2.22, GOC:mah]", "canonical_name": "ribosomal ribonucleate N-glycosidase activity"}
{"concept_id": "C1150030", "aliases": ["uridine ribohydrolase activity", "uridine nucleosidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + uridine = ribofuranose + uracil. [EC:3.2.2.3, RHEA:15577]", "canonical_name": "uridine hydrolase activity"}
{"concept_id": "C1150031", "aliases": ["O-glucosyl hydrolase activity"], "types": ["T044"], "canonical_name": "hydrolase activity, hydrolyzing O-glycosyl compounds", "definition": "Catalysis of the hydrolysis of any O-glycosyl bond. [GOC:mah]"}
{"concept_id": "C1150032", "aliases": ["alpha-glucuronidase activity", "alpha-D-glucosiduronate glucuronohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate. [EC:3.2.1.139]", "canonical_name": "alpha-glucosiduronase activity"}
{"concept_id": "C1150033", "aliases": ["alpha-N-arabinofuranosidase activity", "arabinofuranosidase activity", "alpha-L-arabinofuranoside hydrolase activity", "L-arabinosidase activity", "alpha-arabinosidase activity", "alpha-L-arabinosidase activity", "alpha-L-arabinanase activity", "alpha-L-arabinofuranoside arabinofuranohydrolase activity", "alpha-arabinofuranosidase activity", "arabinosidase activity", "polysaccharide alpha-L-arabinofuranosidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides. [EC:3.2.1.55, GOC:mf]", "canonical_name": "alpha-L-arabinofuranosidase activity"}
{"concept_id": "C1150034", "aliases": ["alpha-L-rhamnosidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides. [EC:3.2.1.40]", "canonical_name": "alpha-L-rhamnoside rhamnohydrolase activity"}
{"concept_id": "C1150035", "aliases": [], "types": ["T044"], "canonical_name": "alpha-sialidase activity", "definition": "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. [GOC:mah]"}
{"concept_id": "C1150037", "aliases": ["neuraminidase activity", "sialidase activity", "alpha-neuraminidase activity", "acetylneuraminyl hydrolase activity", "exo-alpha-sialidase activity", "N-acylneuraminate glycohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. [EC:3.2.1.18]", "canonical_name": "acetylneuraminidase activity"}
{"concept_id": "C1150038", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of amylose or an amylose derivative. [GOC:ai]", "canonical_name": "amylase activity"}
{"concept_id": "C1150039", "aliases": ["alpha-amylase activity", "1,4-alpha-D-glucan glucanohydrolase activity", "alpha amylase activity"], "types": ["T044"], "definition": "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. [PMID:12527308]", "canonical_name": "endoamylase activity"}
{"concept_id": "C1150040", "aliases": ["beta-amylase activity", "saccharogen amylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. [PMID:18390594]", "canonical_name": "beta amylase activity"}
{"concept_id": "C1150042", "aliases": ["beta-D-fructofuranoside fructohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside. [EC:3.2.1.26, MetaCyc:RXN-9985]", "canonical_name": "beta-fructofuranosidase activity"}
{"concept_id": "C1150043", "aliases": ["ketodase activity", "exo-beta-D-glucuronidase activity", "glucuronidase activity", "beta-D-glucuronoside glucuronosohydrolase activity", "beta-glucuronidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. [EC:3.2.1.31]", "canonical_name": "beta-glucuronide glucuronohydrolase activity"}
{"concept_id": "C1150044", "aliases": ["1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity", "9.5 cellulase activity", "cellulase activity"], "types": ["T044"], "definition": "Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. [EC:3.2.1.4]", "canonical_name": "celludextrinase activity"}
{"concept_id": "C1150045", "aliases": ["beta-1,4-glucan cellobiohydrolase activity", "cellobiohydrolase activity", "exo-beta-1,4-glucan cellobiohydrolase activity", "exo-1,4-beta-D-glucanase activity", "exocellobiohydrolase activity", "1,4-beta-cellobiohydrolase activity", "1,4-beta-glucan cellobiosidase activity", "cellobiosidase activity", "C1 cellulase activity", "1,4-beta-D-glucan cellobiohydrolase activity", "exo-cellobiohydrolase activity", "exoglucanase activity", "CBH 1", "beta-1,4-glucan cellobiosylhydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains. [EC:3.2.1.91]", "canonical_name": "cellulose 1,4-beta-cellobiosidase activity"}
{"concept_id": "C1150046", "aliases": ["chitodextrinase activity", "poly-beta-glucosaminidase activity", "beta-1,4-poly-N-acetyl glucosamidinase activity", "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity", "chitinase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]", "canonical_name": "1,4-beta-poly-N-acetylglucosaminidase activity"}
{"concept_id": "C1150047", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain. [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]", "canonical_name": "endochitinase activity"}
{"concept_id": "C1150048", "aliases": ["chitosan N-acetylglucosaminohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan. [EC:3.2.1.132]", "canonical_name": "chitosanase activity"}
{"concept_id": "C1150049", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative. [GOC:ai]", "canonical_name": "fucosidase activity"}
{"concept_id": "C1150050", "aliases": ["alpha-L-fucosidase activity", "alpha-L-fucoside fucohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. [EC:3.2.1.51]", "canonical_name": "alpha-fucosidase activity"}
{"concept_id": "C1150051", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. [GOC:ai]", "canonical_name": "galactosidase activity"}
{"concept_id": "C1150052", "aliases": ["melibiase activity", "alpha-D-galactoside galactohydrolase activity", "alpha-D-galactosidase activity", "alpha-galactosidase activity", "alpha-galactosidase A"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase. [EC:3.2.1.22]", "canonical_name": "alpha-galactoside galactohydrolase activity"}
{"concept_id": "C1150053", "aliases": ["beta-lactosidase activity", "exo-(1->4)-beta-D-galactanase activity", "beta-D-galactanase activity", "beta-D-lactosidase activity", "beta-D-galactoside galactohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. [EC:3.2.1.23]", "canonical_name": "beta-galactosidase activity"}
{"concept_id": "C1150054", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. [ISBN:0198506732]", "canonical_name": "glucosidase activity"}
{"concept_id": "C1150055", "aliases": ["glucoinvertase activity", "glucosidosucrase activity", "maltase-glucoamylase activity", "alpha-glucoside hydrolase activity", "glucosidoinvertase activity", "alpha-1,4-glucosidase activity", "acid maltase activity", "alpha-D-glucoside glucohydrolase activity", "alpha-D-glucosidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. [EC:3.2.1.20]", "canonical_name": "alpha-glucopyranosidase activity"}
{"concept_id": "C1150056", "aliases": ["beta-glucosidase activity", "beta-D-glucoside glucohydrolase activity", "p-nitrophenyl beta-glucosidase activity", "beta-D-glucosidase activity", "aryl-beta-glucosidase activity", "arbutinase activity", "beta-glucoside glucohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. [EC:3.2.1.21, PMID:12594539]", "canonical_name": "beta-1,6-glucosidase activity"}
{"concept_id": "C1150057", "aliases": ["phosphocellobiase activity", "6-phospho-beta-glucosidase activity", "phospho-beta-glucosidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose. [EC:3.2.1.86]", "canonical_name": "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity"}
{"concept_id": "C1150058", "aliases": [], "types": ["T044"], "canonical_name": "cytokine beta-glucosidase activity"}
{"concept_id": "C1150059", "aliases": [], "types": ["T044"], "canonical_name": "glucan 1,3-beta-glucosidase activity"}
{"concept_id": "C1150060", "aliases": ["glucan 1,4-alpha-glucosidase activity", "amyloglucosidase activity", "glucose amylase activity", "glucoamylase activity", "gamma-amylase activity", "gamma-1,4-glucan glucohydrolase activity", "1,4-alpha-D-glucan glucohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. [EC:3.2.1.3]", "canonical_name": "exo-1,4-alpha-glucosidase activity"}
{"concept_id": "C1150061", "aliases": ["endo-1,6-beta-D-glucanase activity", "glucan endo-1,6-beta-glucosidase activity", "beta-1,6-glucan 6-glucanohydrolase activity", "beta-1,6-glucanase-pustulanase activity", "beta-1,6-glucanase activity", "endo-(1,6)-beta-D-glucanase activity", "endo-(1->6)-beta-D-glucanase activity", "endo-beta-1,6-glucanase activity", "beta-1,6-glucan hydrolase activity", "beta-1->6-glucan hydrolase activity", "1,6-beta-D-glucan glucanohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans. [EC:3.2.1.75]", "canonical_name": "endo-1,6-beta-glucanase activity"}
{"concept_id": "C1150062", "aliases": ["mannosyl-oligosaccharide glucosidase activity", "trimming glucosidase I", "Glc3Man9GlcNAc2 oligosaccharide glucosidase activity", "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity"], "types": ["T044"], "definition": "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). [EC:3.2.1.106]", "canonical_name": "mannosyl-oligosaccharide glucohydrolase activity"}
{"concept_id": "C1150063", "aliases": ["oligo-1,6-glucosidase activity", "dextrin 6-glucanohydrolase activity", "alpha-limit dextrinase activity", "oligosaccharide alpha-1,6-glucohydrolase activity", "dextrin 6alpha-glucanohydrolase activity", "oligosaccharide alpha-1,6-glucosidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. [EC:3.2.1.10]", "canonical_name": "exo-oligo-1,6-glucosidase activity"}
{"concept_id": "C1150064", "aliases": ["sucrose alpha-D-glucohydrolase activity", "sucrase-isomaltase activity", "sucrose alpha-glucosidase activity", "sucrose-alpha-D-glucohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose. [EC:3.2.1.48, MetaCyc:RXN-1461]", "canonical_name": "sucrose alpha-glucohydrolase activity"}
{"concept_id": "C1150065", "aliases": ["glucuronyl hydrolase activity"], "types": ["T044"], "canonical_name": "glycuronidase activity", "definition": "Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid. [PMID:10441389, PMID:12044176]"}
{"concept_id": "C1150066", "aliases": [], "types": ["T044"], "definition": "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. [PMID:10916150]", "canonical_name": "heparanase activity"}
{"concept_id": "C1150067", "aliases": [], "types": ["T044"], "definition": "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. [ISBN:0721662544]", "canonical_name": "hexosaminidase activity"}
{"concept_id": "C1150068", "aliases": ["alpha-acetylgalactosaminidase activity", "N-acetyl-alpha-D-galactosaminidase activity", "alpha-NAGA activity", "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity", "alpha-N-acetylgalactosaminidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. [EC:3.2.1.49]", "canonical_name": "N-acetyl-alpha-galactosaminidase activity"}
{"concept_id": "C1150069", "aliases": ["NAG activity", "alpha-acetylglucosaminidase activity", "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity", "alpha-N-acetylglucosaminidase activity", "N-acetyl-alpha-glucosaminidase activity", "N-acetyl-alpha-D-glucosaminidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. [EC:3.2.1.50]", "canonical_name": "alpha-D-2-acetamido-2-deoxyglucosidase activity"}
{"concept_id": "C1150070", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]", "canonical_name": "beta-N-acetylglucosaminidase activity"}
{"concept_id": "C1150071", "aliases": ["N-acetyl-beta-D-hexosaminidase activity", "N-acetyl-beta-glucosaminidase activity", "N-acetylhexosaminidase activity", "beta-D-N-acetylhexosaminidase activity", "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity", "N-acetyl-beta-hexosaminidase activity", "beta-acetylaminodeoxyhexosidase activity", "beta-N-acetyl-D-hexosaminidase activity", "beta-N-acetylhexosaminidase activity", "beta-D-hexosaminidase activity", "beta-acetylhexosaminidinase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. [EC:3.2.1.52]", "canonical_name": "beta-hexosaminidase activity"}
{"concept_id": "C1150072", "aliases": ["hyalurononglucosaminidase activity", "hyaluronate 4-glycanohydrolase activity", "chondroitinase I activity", "hyaluronoglucosaminidase activity"], "types": ["T044"], "definition": "Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. [EC:3.2.1.35]", "canonical_name": "hyaluronoglucosidase activity"}
{"concept_id": "C1150073", "aliases": ["phosphodiester glycosidase activity", "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity", "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity", "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity", "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose. [EC:3.1.4.45]", "canonical_name": "alpha-N-acetylglucosaminyl phosphodiesterase activity"}
{"concept_id": "C1150074", "aliases": ["alpha-L-iduronidase activity", "glycosaminoglycan alpha-L-iduronohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate. [EC:3.2.1.76]", "canonical_name": "L-iduronidase activity"}
{"concept_id": "C1150075", "aliases": ["lactose galactohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. [PMID:12023280]", "canonical_name": "lactase activity"}
{"concept_id": "C1150076", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. [GOC:ai]", "canonical_name": "mannosidase activity"}
{"concept_id": "C1150077", "aliases": ["alpha-D-mannopyranosidase activity", "alpha-D-mannoside mannohydrolase activity", "alpha-mannosidase activity", "exo-alpha-mannosidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. [EC:3.2.1.24]", "canonical_name": "alpha-D-mannosidase activity"}
{"concept_id": "C1150078", "aliases": ["glycoprotein glucosylmannohydrolase activity", "endomannosidase activity", "endo-alpha-mannosidase activity", "glucosylmannosidase activity", "glucosyl mannosidase activity"], "types": ["T044"], "canonical_name": "glycoprotein endo-alpha-1,2-mannosidase activity", "definition": "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane. [EC:3.2.1.130]"}
{"concept_id": "C1150079", "aliases": ["1,6-alpha-D-mannan mannanohydrolase activity", "endo-alpha-D-mannosidase activity", "exo-1,6-beta-mannanase activity", "mannan endo-1,6-alpha-mannosidase activity", "1,6-beta-D-mannan mannanohydrolase activity", "endo-1,6-beta-mannanase activity", "mannan endo-1,6-beta-mannosidase activity"], "types": ["T044"], "definition": "Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans. [EC:3.2.1.101]", "canonical_name": "endo-alpha-1->6-D-mannanase activity"}
{"concept_id": "C1150080", "aliases": ["beta-D-mannoside mannohydrolase activity", "mannase activity", "beta-mannoside mannohydrolase activity", "beta-D-mannosidase activity", "mannanase activity", "exo-beta-D-mannanase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. [EC:3.2.1.25]", "canonical_name": "beta-mannosidase activity"}
{"concept_id": "C1150081", "aliases": ["beta-D-mannanase activity", "endo-beta-1,4-mannase activity", "1,4-beta-D-mannan mannanohydrolase activity", "beta-1,4-mannan 4-mannanohydrolase activity", "mannan endo-1,4-beta-mannosidase activity"], "types": ["T044"], "definition": "Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans. [EC:3.2.1.78]", "canonical_name": "endo-1,4-beta-mannanase activity"}
{"concept_id": "C1150082", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+. [MetaCyc:GDPMANMANHYDRO-RXN]", "canonical_name": "GDP-mannose mannosyl hydrolase activity"}
{"concept_id": "C1150083", "aliases": [], "types": ["T044"], "canonical_name": "mannosyl-oligosaccharide mannosidase activity", "definition": "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. [EC:3.2.1.-, GOC:ai]"}
{"concept_id": "C1150084", "aliases": ["1,2-alpha-mannosidase", "exo-alpha-1,2-mannanase activity", "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity", "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. [GOC:bf, PMID:25092655]", "canonical_name": "mannosidase I"}
{"concept_id": "C1150085", "aliases": ["exo-1,3-1,6-alpha-mannosidase activity", "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity", "mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity", "alpha-D-mannosidase II", "Golgi alpha-mannosidase II", "mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity", "mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity", "alpha-(1,3/6)-mannosidase activity", "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). [EC:3.2.1.114]", "canonical_name": "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"}
{"concept_id": "C1150086", "aliases": [], "types": ["T044"], "canonical_name": "murein transglycosylase B activity"}
{"concept_id": "C1150087", "aliases": ["endo-polygalacturonase activity", "pectin hydrolase activity", "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity", "endo-D-galacturonase activity", "polygalacturonase activity", "endogalacturonase activity", "poly-alpha-1,4-galacturonide glycanohydrolase activity", "endopolygalacturonase activity", "pectin polygalacturonase activity"], "types": ["T044"], "definition": "Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans. [EC:3.2.1.15]", "canonical_name": "pectolase activity"}
{"concept_id": "C1150088", "aliases": ["S-ribosylhomocysteine lyase activity", "LuxS", "ribosylhomocysteinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine. [RHEA:17753]", "canonical_name": "S-ribosylhomocysteinase activity"}
{"concept_id": "C1150089", "aliases": ["myrosinase activity", "sinigrinase activity", "thioglucosidase activity", "thioglucoside glucohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar. [EC:3.2.1.147]", "canonical_name": "sinigrase activity"}
{"concept_id": "C1150090", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of trehalose or a trehalose derivative. [GOC:ai, PMID:31925485]", "canonical_name": "trehalase activity"}
{"concept_id": "C1150091", "aliases": ["trehalose-6-phosphate hydrolase activity", "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity", "alpha,alpha-phosphotrehalase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate. [EC:3.2.1.93]", "canonical_name": "phosphotrehalase activity"}
{"concept_id": "C1150092", "aliases": ["alpha,alpha-trehalose glucohydrolase activity"], "types": ["T044"], "canonical_name": "alpha,alpha-trehalase activity", "definition": "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. [PMID:19897915, RHEA:32675]"}
{"concept_id": "C1150093", "aliases": ["1,4-beta-D-xylan xylohydrolase activity", "xylobiase activity", "beta-xylosidase activity", "exo-1,4-beta-xylosidase activity", "beta-D-xylopyranosidase activity", "exo-1,4-xylosidase activity", "exo-1,4-beta-D-xylosidase activity"], "types": ["T044"], "canonical_name": "xylan 1,4-beta-xylosidase activity", "definition": "Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini. [EC:3.2.1.37]"}
{"concept_id": "C1150095", "aliases": ["peptide hydrolase activity", "proteinase", "protease activity", "peptidase activity", "hydrolase, acting on peptide bonds"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]", "canonical_name": "proteinase activity"}
{"concept_id": "C1150096", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]", "canonical_name": "aminopeptidase activity"}
{"concept_id": "C1150105", "aliases": ["lymphopeptidase activity", "peptidase T", "alanine-phenylalanine-proline arylamidase activity", "tripeptide aminopeptidase activity", "aminotripeptidase activity", "imidoendopeptidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide. [EC:3.4.11.4]", "canonical_name": "aminoexotripeptidase activity"}
{"concept_id": "C1150108", "aliases": ["aspartic endopeptidase activity"], "types": ["T044"], "canonical_name": "aspartic-type endopeptidase activity", "definition": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. [ISBN:0198506732]"}
{"concept_id": "C1150109", "aliases": [], "types": ["T044"], "canonical_name": "aspartic endopeptidase activity, intramembrane cleaving", "definition": "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1150123", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent peptidase activity", "definition": "Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. [GOC:mah]"}
{"concept_id": "C1150124", "aliases": ["cysteine-type peptidase activity", "thiol protease activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]", "canonical_name": "cysteine protease activity"}
{"concept_id": "C1150125", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type carboxypeptidase activity", "definition": "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]"}
{"concept_id": "C1150126", "aliases": ["thiol endopeptidase activity"], "types": ["T044"], "canonical_name": "cysteine-type endopeptidase activity", "definition": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]"}
{"concept_id": "C1150129", "aliases": [], "types": ["T044"], "canonical_name": "calpain activity"}
{"concept_id": "C1150130", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue. [PMID:10872455]", "canonical_name": "caspase activity"}
{"concept_id": "C1150131", "aliases": [], "types": ["T044"], "canonical_name": "effector caspase activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1150136", "aliases": [], "types": ["T044"], "canonical_name": "signaling (initiator) caspase activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1150153", "aliases": ["ubiquitin-like specific protease activity", "ubiquitin-like protein peptidase activity", "ubiquitin-like protein-specific protease activity", "small conjugating protein-specific isopeptidase activity", "ubiquitin-like hydrolase activity", "small conjugating protein-specific protease activity", "ubiquitin-like protein-specific isopeptidase activity", "ubiquitinyl-like hydrolase activity"], "types": ["T044"], "definition": "An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins. [PMID:19489724]", "canonical_name": "ubiquitin-like-protein-specific protease activity"}
{"concept_id": "C1150154", "aliases": [], "types": ["T044"], "canonical_name": "APG8-PE hydrolase"}
{"concept_id": "C1150155", "aliases": ["ISG15-specific protease activity"], "types": ["T044"], "canonical_name": "ISG15-specific peptidase activity", "definition": "A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated. [GOC:mah, PMID:30213559]"}
{"concept_id": "C1150156", "aliases": ["NEDD8-specific protease activity"], "types": ["T044"], "canonical_name": "deNEDDylase activity", "definition": "An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. [GOC:mah, PMID:25628956]"}
{"concept_id": "C1150157", "aliases": ["SUMO-specific protease activity", "SUSP", "deSUMOylase activity", "ULP"], "types": ["T044"], "definition": "An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated. [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250, PMID:23746258]", "canonical_name": "SUMO-specific isopeptidase activity"}
{"concept_id": "C1150158", "aliases": ["thiol-dependent ubiquitinyl hydrolase activity", "cysteine-type deubiquitinase activity", "ubiquitin-specific protease activity", "deubiquitylase", "deubiquitinase", "thiol-dependent ubiquitin-specific protease activity", "thiol-dependent deubiquitinase", "UCH2", "UBP"], "types": ["T044"], "definition": "An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]", "canonical_name": "deubiquitinating enzyme"}
{"concept_id": "C1150160", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a dipeptide. [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]", "canonical_name": "dipeptidase activity"}
{"concept_id": "C1150165", "aliases": [], "types": ["T044"], "canonical_name": "dipeptidyl-peptidase activity", "definition": "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]"}
{"concept_id": "C1150171", "aliases": ["endoprotease activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]", "canonical_name": "endopeptidase activity"}
{"concept_id": "C1150172", "aliases": ["metalloendoprotease activity", "metalloendopeptidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]", "canonical_name": "metalloendoproteinase activity"}
{"concept_id": "C1150209", "aliases": ["exoprotease activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. [https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]", "canonical_name": "exopeptidase activity"}
{"concept_id": "C1150210", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]", "canonical_name": "carboxypeptidase activity"}
{"concept_id": "C1150211", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]", "canonical_name": "metalloexopeptidase activity"}
{"concept_id": "C1150212", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]", "canonical_name": "metallocarboxypeptidase activity"}
{"concept_id": "C1150221", "aliases": ["Zn2+ G peptidase activity", "zinc D-Ala-D-Ala carboxypeptidase activity", "D-alanyl-D-alanine-cleaving carboxypeptidase activity", "DD-carboxypeptidase-transpeptidase activity"], "types": ["T044"], "definition": "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine. [EC:3.4.17.14]", "canonical_name": "D-alanyl-D-alanine hydrolase activity"}
{"concept_id": "C1150224", "aliases": ["metalloproteinase activity", "metalloprotease activity"], "types": ["T044"], "canonical_name": "metallopeptidase activity", "definition": "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]"}
{"concept_id": "C1150228", "aliases": [], "types": ["T044"], "definition": "Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes. [EC:3.4.19.-, PMID:20157488, PMID:9920379]", "canonical_name": "omega peptidase activity"}
{"concept_id": "C1150229", "aliases": ["beta-aspartyl peptidase activity", "beta-aspartyl dipeptidase activity"], "types": ["T044"], "definition": "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide. [EC:3.4.19.5]", "canonical_name": "beta-aspartyl-peptidase activity"}
{"concept_id": "C1150231", "aliases": [], "types": ["T044"], "canonical_name": "pyroglutamyl-peptidase activity", "definition": "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein. [GOC:mah, PMID:9920379]"}
{"concept_id": "C1150237", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-dipeptidase activity", "definition": "Catalysis of the release of C-terminal dipeptides from a polypeptide chain. [GOC:mb]"}
{"concept_id": "C1150239", "aliases": ["serine protease activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]", "canonical_name": "serine-type peptidase activity"}
{"concept_id": "C1150240", "aliases": ["serine carboxypeptidase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]", "canonical_name": "serine-type carboxypeptidase activity"}
{"concept_id": "C1150244", "aliases": ["serine-type D-Ala-D-Ala carboxypeptidase activity", "DD-peptidase activity", "D-alanyl-D-alanine-cleaving peptidase activity", "D-alanyl-D-alanine-carboxypeptidase activity", "D-alanyl-D-alanine carboxypeptidase activity", "DD-transpeptidase activity", "D-alanyl-D-alanine-cleaving-peptidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. [EC:3.4.16.4]", "canonical_name": "D-alanyl carboxypeptidase activity"}
{"concept_id": "C1150245", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]", "canonical_name": "serine-type endopeptidase activity"}
{"concept_id": "C1150287", "aliases": [], "types": ["T044"], "canonical_name": "tripeptidyl-peptidase activity", "definition": "Catalysis of the release of an N-terminal tripeptide from a polypeptide. [GOC:mah]"}
{"concept_id": "C1150292", "aliases": ["threonine endopeptidase activity", "MCP"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]", "canonical_name": "threonine-type endopeptidase activity"}
{"concept_id": "C1150293", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity. [EC:3.4.25.1]", "canonical_name": "proteasome endopeptidase activity"}
{"concept_id": "C1150294", "aliases": [], "types": ["T044"], "canonical_name": "serine hydrolase activity", "definition": "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [Wikipedia:Serine_hydrolase]"}
{"concept_id": "C1150295", "aliases": ["imidazole glycerol phosphate synthase activity", "imidazole-glycerol-phosphate synthase activity", "imidazoleglycerol phosphate synthase activity"], "types": ["T044"], "canonical_name": "imidazoleglycerol-phosphate synthase activity", "definition": "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+). [RHEA:24793]"}
{"concept_id": "C1150296", "aliases": [], "types": ["T044"], "definition": "Catalysis of the integration of one DNA segment into another. [GOC:mah]", "canonical_name": "integrase activity"}
{"concept_id": "C1150297", "aliases": ["integrase activity involved in establishment of integrated proviral latency"], "types": ["T045"], "canonical_name": "prophage integrase activity", "definition": "Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA. [GOC:jl]"}
{"concept_id": "C1150298", "aliases": [], "types": ["T044"], "definition": "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. [ISBN:0198506732]", "canonical_name": "isomerase activity"}
{"concept_id": "C1150299", "aliases": [], "types": ["T044"], "canonical_name": "cis-trans isomerase activity", "definition": "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1150300", "aliases": [], "types": ["T044"], "canonical_name": "carotenoid isomerase activity", "definition": "Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids. [PMID:11884677]"}
{"concept_id": "C1150301", "aliases": ["peptidylproline cis-trans-isomerase activity", "peptide bond isomerase activity", "peptidylprolyl cis-trans isomerase activity", "cis-trans proline isomerase activity", "peptidyl-prolyl cis-trans isomerase activity", "PPIase activity", "rotamase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8]", "canonical_name": "peptidylprolyl isomerase activity"}
{"concept_id": "C1150302", "aliases": [], "types": ["T044"], "canonical_name": "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity", "definition": "OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0). [EC:5.2.1.8]"}
{"concept_id": "C1150304", "aliases": ["retinal isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal. [PMID:21447403]", "canonical_name": "all-trans-retinal 11-cis-trans-isomerase activity"}
{"concept_id": "C1150305", "aliases": ["intramolecular isomerase activity"], "types": ["T044"], "canonical_name": "intramolecular oxidoreductase activity", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. [EC:5.3.-.-, GOC:curators]"}
{"concept_id": "C1150306", "aliases": ["intramolecular isomerase activity, interconverting aldoses and ketoses"], "types": ["T044"], "canonical_name": "intramolecular oxidoreductase activity, interconverting aldoses and ketoses", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. [GOC:jl]"}
{"concept_id": "C1150307", "aliases": ["phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity", "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity", "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity", "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity", "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity", "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity"], "types": ["T044"], "canonical_name": "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity", "definition": "Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. [EC:5.3.1.16, RHEA:15469]"}
{"concept_id": "C1150308", "aliases": ["4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity", "4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity", "5-keto-4-deoxyuronate isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate. [EC:5.3.1.17, RHEA:23896]", "canonical_name": "4-deoxy-L-threo-5-hexulose uronate isomerase activity"}
{"concept_id": "C1150309", "aliases": ["5-methylthioribose-1-phosphate isomerase activity", "MTR-1-P isomerase activity", "1-PMTR isomerase activity", "methylthioribose 1-phosphate isomerase activity", "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity", "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity", "S-methyl-5-thioribose-1-phosphate isomerase activity", "1-phospho-5'-S-methylthioribose isomerase activity", "5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity", "S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. [EC:5.3.1.23, RHEA:19989]", "canonical_name": "S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity"}
{"concept_id": "C1150310", "aliases": [], "types": ["T044"], "canonical_name": "allose 6-phosphate isomerase activity", "definition": "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate. [MetaCyc:RXN0-303]"}
{"concept_id": "C1150311", "aliases": ["D-arabinose(L-fucose) isomerase activity", "D-arabinose aldose-ketose-isomerase activity", "D-arabinose ketol-isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-arabinose = D-ribulose. [EC:5.3.1.3]", "canonical_name": "arabinose isomerase activity"}
{"concept_id": "C1150312", "aliases": ["D-arabinose-5-phosphate ketol-isomerase activity", "arabinose-5-phosphate isomerase activity", "arabinose phosphate isomerase activity", "phosphoarabinoisomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+). [EC:5.3.1.13, RHEA:23104]", "canonical_name": "D-arabinose-5-phosphate aldose-ketose-isomerase activity"}
{"concept_id": "C1150313", "aliases": ["11-deoxycorticosterone ketol-isomerase activity", "11-deoxycorticosterone aldose-ketose-isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al. [EC:5.3.1.21, RHEA:17861]", "canonical_name": "corticosteroid side-chain-isomerase activity"}
{"concept_id": "C1150314", "aliases": ["glucosamine phosphate deaminase activity", "GlcN6P deaminase activity", "phosphoglucosaminisomerase activity", "aminodeoxyglucosephosphate isomerase activity", "phosphoglucosamine isomerase activity", "glucosamine-6-phosphate isomerase activity", "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+). [EC:3.5.99.6, RHEA:12172]", "canonical_name": "glucosamine-6-phosphate deaminase activity"}
{"concept_id": "C1150315", "aliases": ["glucose-6-phosphate isomerase activity", "phosphoglucose isomerase activity", "D-glucose-6-phosphate ketol-isomerase activity", "hexosephosphate isomerase activity", "D-glucose-6-phosphate aldose-ketose-isomerase activity", "phosphoglucoisomerase activity", "glucose phosphate isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. [EC:5.3.1.9]", "canonical_name": "hexose phosphate isomerase activity"}
{"concept_id": "C1150316", "aliases": ["uronate isomerase activity", "uronic isomerase activity", "D-glucuronate isomerase activity", "uronic acid isomerase activity", "D-glucuronate aldose-ketose-isomerase activity", "glucuronate isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucuronate = D-fructuronate. [EC:5.3.1.12]", "canonical_name": "D-glucuronate ketol-isomerase activity"}
{"concept_id": "C1150317", "aliases": ["hydroxypyruvate ketol-isomerase activity", "hydroxypyruvate isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. [EC:5.3.1.22, RHEA:11952]", "canonical_name": "hydroxypyruvate aldose-ketose-isomerase activity"}
{"concept_id": "C1150318", "aliases": ["L-arabinose isomerase activity", "L-arabinose aldose-ketose-isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-arabinose = L-ribulose. [EC:5.3.1.4, RHEA:14821]", "canonical_name": "L-arabinose ketol-isomerase activity"}
{"concept_id": "C1150319", "aliases": ["L-fucose ketol-isomerase activity", "L-fucose isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-fucose = L-fuculose. [EC:5.3.1.25]", "canonical_name": "L-fucose aldose-ketose-isomerase activity"}
{"concept_id": "C1150320", "aliases": ["L-rhamnose aldose-ketose-isomerase activity", "L-rhamnose isomerase activity", "rhamnose isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-rhamnose = L-rhamnulose. [EC:5.3.1.14, RHEA:23160]", "canonical_name": "L-rhamnose ketol-isomerase activity"}
{"concept_id": "C1150321", "aliases": ["phosphomannose isomerase activity", "phosphomannoisomerase activity", "mannose-6-phosphate isomerase activity", "D-mannose-6-phosphate ketol-isomerase activity", "mannose phosphate isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. [EC:5.3.1.8]", "canonical_name": "D-mannose-6-phosphate aldose-ketose-isomerase activity"}
{"concept_id": "C1150322", "aliases": ["N-(5'-phosphoribosyl)anthranilate isomerase activity", "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity", "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity", "PRA isomerase activity", "PRAI activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. [EC:5.3.1.24, RHEA:21540]", "canonical_name": "phosphoribosylanthranilate isomerase activity"}
{"concept_id": "C1150323", "aliases": ["D-ribose-5-phosphate ketol-isomerase activity", "pentose phosphate isomerase (PPI)", "D-ribose 5-phosphate isomerase activity", "5-phosphoribose isomerase activity", "phosphopentoseisomerase activity", "ribose 5-phosphate epimerase activity", "ribose phosphate isomerase activity", "D-ribose-5-phosphate aldose-ketose-isomerase activity", "ribose-5-phosphate isomerase activity", "phosphopentosisomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. [EC:5.3.1.6, RHEA:14657]", "canonical_name": "phosphoriboisomerase activity"}
{"concept_id": "C1150324", "aliases": ["D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity", "triose-phosphate isomerase activity", "triose phosphoisomerase activity", "D-glyceraldehyde-3-phosphate ketol-isomerase activity", "triosephosphate isomerase activity", "triose phosphate mutase activity", "phosphotriose isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. [EC:5.3.1.1, RHEA:18585]", "canonical_name": "triosephosphate mutase activity"}
{"concept_id": "C1150325", "aliases": ["D-xylose isomerase activity", "D-xylose ketoisomerase activity", "D-xylose aldose-ketose-isomerase activity", "xylose isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-xylose = D-xylulose. [EC:5.3.1.5]", "canonical_name": "D-xylose ketol-isomerase activity"}
{"concept_id": "C1150326", "aliases": ["intramolecular isomerase activity, interconverting keto- and enol-groups"], "types": ["T044"], "canonical_name": "intramolecular oxidoreductase activity, interconverting keto- and enol-groups", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears. [GOC:jl]"}
{"concept_id": "C1150327", "aliases": [], "types": ["T044"], "canonical_name": "intramolecular oxidoreductase activity, other intramolecular oxidoreductases", "definition": "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized. [GOC:ai]"}
{"concept_id": "C1150328", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate. [RHEA:27401]", "canonical_name": "2-hydroxychromene-2-carboxylate isomerase activity"}
{"concept_id": "C1150329", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxytetrahydrofuran isomerase activity", "definition": "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde. [UM-BBD_reactionID:r0019]"}
{"concept_id": "C1150330", "aliases": ["(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate. [EC:5.3.99.6, RHEA:22592]", "canonical_name": "allene-oxide cyclase activity"}
{"concept_id": "C1150331", "aliases": ["crtL"], "types": ["T044"], "canonical_name": "lycopene beta cyclase activity", "definition": "Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively. [PMID:8837512]"}
{"concept_id": "C1150332", "aliases": [], "types": ["T044"], "canonical_name": "lycopene epsilon cyclase activity", "definition": "Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene). [PMID:8837512]"}
{"concept_id": "C1150333", "aliases": ["prostaglandin-H2 D-isomerase activity", "prostaglandin-R-prostaglandin D isomerase activity", "prostaglandin D2 synthase activity", "PGD2 synthase activity", "PGH-PGD isomerase activity", "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity"], "types": ["T044"], "canonical_name": "prostaglandin-D synthase activity", "definition": "Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). [EC:5.3.99.2, RHEA:10600]"}
{"concept_id": "C1150334", "aliases": ["styrene-oxide isomerase (epoxide-cleaving)", "styrene-oxide isomerase activity", "styrene oxide isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: styrene oxide = phenylacetaldehyde. [EC:5.3.99.7, RHEA:21604]", "canonical_name": "SOI activity"}
{"concept_id": "C1150335", "aliases": ["intramolecular isomerase activity, transposing C=C bonds"], "types": ["T044"], "canonical_name": "intramolecular oxidoreductase activity, transposing C=C bonds", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. [EC:5.3.3.-, GOC:mah]"}
{"concept_id": "C1150338", "aliases": ["hpaG-1", "5-carboxymethyl-2-hydroxymuconic acid isomerase activity", "HHDD isomerase activity", "CHM isomerase activity", "5-carboxymethyl-2-hydroxymuconate delta-isomerase activity", "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity", "5-carboxymethyl-2-hydroxymuconate D-isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. [EC:5.3.3.10]", "canonical_name": "hpaG1"}
{"concept_id": "C1150339", "aliases": ["C-8 sterol isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. [MetaCyc:RXN3O-203, PMID:8988026]", "canonical_name": "delta-8-delta-7 sterol isomerase activity"}
{"concept_id": "C1150341", "aliases": ["delta3-cis-delta2-trans-enoyl-CoA isomerase", "dodecenoyl-CoA delta-isomerase activity", "delta3-delta2 enoyl-CoA isomerase activity", "delta(3)-delta(2)-enoyl-CoA isomerase activity", "dodecenoyl-CoA D-isomerase activity", "dodecenoyl-CoA (3Z)-(2E)-isomerase activity", "3,2-trans-enoyl-CoA isomerase activity", "delta(3),delta(2)-enoyl-CoA isomerase activity", "delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase activity", "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity", "dodecenoyl-CoA isomerase activity", "delta3,delta2-enoyl-CoA isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA. [RHEA:45900]", "canonical_name": "acetylene-allene isomerase activity"}
{"concept_id": "C1150342", "aliases": ["dopachrome keto-enol isomerase activity", "DCT activity", "dopachrome delta7,Delta2-isomerase activity", "DCF activity", "dopachrome tautomerase activity", "dopachrome-rearranging enzyme", "L-dopachrome keto-enol isomerase activity", "TRP2", "dopachrome delta-isomerase activity", "dopachrome conversion activity", "dopachrome isomerase activity", "dopachrome Delta(7),Delta(2)-isomerase activity", "dopachrome oxidoreductase activity", "tyrosinase-related protein 2 activity", "dopachrome rearranging enzyme activity", "L-dopachrome isomerase activity", "TRP activity", "TRP-2", "TRP-1"], "types": ["T044"], "definition": "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. [EC:5.3.3.12, RHEA:13041]", "canonical_name": "L-dopachrome-methyl ester tautomerase activity"}
{"concept_id": "C1150343", "aliases": ["isopentenyl-diphosphate delta3-delta2-isomerase activity", "IPP isomerase activity", "isopentenylpyrophosphate isomerase activity", "isopentenylpyrophosphate delta-isomerase activity", "methylbutenylpyrophosphate isomerase activity", "isopentenyl-diphosphate delta-isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. [RHEA:23284]", "canonical_name": "isopentenyl-diphosphate D-isomerase activity"}
{"concept_id": "C1150344", "aliases": ["muconolactone delta-isomerase activity", "muconolactone D-isomerase activity", "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate. [RHEA:12348]", "canonical_name": "muconolactone isomerase activity"}
{"concept_id": "C1150345", "aliases": ["steroid D-isomerase activity", "delta5-3-ketosteroid isomerase activity", "3-oxosteroid isomerase activity", "hydroxysteroid isomerase activity", "3-oxosteroid delta5-delta4-isomerase activity", "delta5-ketosteroid isomerase activity", "delta5(or delta4)-3-keto steroid isomerase activity", "delta5-steroid isomerase activity", "delta(5)-3-oxosteroid isomerase activity", "delta(5)-3-ketosteroid isomerase activity", "delta5-3-keto steroid isomerase activity", "steroid delta-isomerase activity", "steroid isomerase activity", "delta5-3-oxosteroid isomerase activity", "delta(5)-steroid isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. [EC:5.3.3.1]", "canonical_name": "delta(5)-3-keto steroid isomerase activity"}
{"concept_id": "C1150346", "aliases": ["intramolecular isomerase activity, transposing S-S bonds"], "types": ["T044"], "canonical_name": "intramolecular oxidoreductase activity, transposing S-S bonds", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. [EC:5.3.4.-, GOC:mah]"}
{"concept_id": "C1150347", "aliases": ["protein disulfide-isomerase", "protein disulphide isomerase activity", "protein thiol-disulfide exchange", "protein thiol-disulphide exchange", "disulphide bond formation", "protein disulfide isomerase activity", "protein disulfide-isomerase reaction"], "types": ["T044"], "definition": "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]", "canonical_name": "disulphide bond biosynthesis"}
{"concept_id": "C1150348", "aliases": [], "types": ["T044"], "canonical_name": "intramolecular lyase activity", "definition": "The catalysis of certain rearrangements of a molecule to break or form a ring. [GOC:jl]"}
{"concept_id": "C1150349", "aliases": [], "types": ["T044"], "canonical_name": "alpha-pinene lyase activity", "definition": "Catalysis of the reaction: alpha-pinene = limonene. [UM-BBD_reactionID:r0712]"}
{"concept_id": "C1150350", "aliases": ["alpha-pinene-oxide decyclase activity", "alpha-pinene-oxide lyase (decyclizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal. [EC:5.5.1.10, RHEA:16693]", "canonical_name": "alpha-pinene oxide lyase activity"}
{"concept_id": "C1150351", "aliases": ["chalcone--flavonone isomerase activity", "chalcone isomerase activity", "chalcone-flavanone isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a chalcone = a flavanone. [EC:5.5.1.6]", "canonical_name": "flavanone lyase (decyclizing)"}
{"concept_id": "C1150352", "aliases": ["2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)", "muconate cycloisomerase II activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate. [EC:5.5.1.7]", "canonical_name": "chloromuconate cycloisomerase activity"}
{"concept_id": "C1150353", "aliases": ["2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate. [EC:5.5.1.11]", "canonical_name": "dichloromuconate cycloisomerase activity"}
{"concept_id": "C1150354", "aliases": ["ent-copalyl diphosphate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate. [EC:5.5.1.13, RHEA:14841]", "canonical_name": "ent-copalyl-diphosphate lyase (decyclizing)"}
{"concept_id": "C1150355", "aliases": ["1L-myo-inositol-1-phosphate lyase (isomerizing)", "D-glucose 6-phosphate cycloaldolase activity", "inositol 1-phosphate synthetase activity", "inositol-3-phosphate synthase activity", "glucose 6-phosphate cyclase activity", "inositol 1-phosphate synthatase activity", "glucose-6-phosphate inositol monophosphate cycloaldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. [EC:5.5.1.4, RHEA:10716]", "canonical_name": "glucocycloaldolase activity"}
{"concept_id": "C1150356", "aliases": ["cis,cis-muconate cycloisomerase activity", "cis,cis-muconate-lactonizing enzyme", "muconate lactonizing enzyme activity", "muconate cycloisomerase I activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate. [RHEA:30031]", "canonical_name": "muconate cycloisomerase activity"}
{"concept_id": "C1150357", "aliases": [], "types": ["T044"], "canonical_name": "pinocarveol isomerase activity", "definition": "Catalysis of the reaction: pinocarveol = carveol. [UM-BBD_reactionID:r0715]"}
{"concept_id": "C1150358", "aliases": ["intramolecular transferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of a functional group from one position to another within a single molecule. [GOC:mah]", "canonical_name": "mutase activity"}
{"concept_id": "C1150359", "aliases": ["intramolecular transferase activity, phosphotransferases", "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers"], "types": ["T044"], "definition": "Catalysis of the transfer of a phosphate group from one position to another within a single molecule. [GOC:mah]", "canonical_name": "phosphomutase activity"}
{"concept_id": "C1150360", "aliases": ["beta-D-glucose 1,6-phosphomutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate. [EC:5.4.2.6, RHEA:20113]", "canonical_name": "beta-phosphoglucomutase activity"}
{"concept_id": "C1150361", "aliases": ["bisphosphoglycerate mutase activity", "biphosphoglycerate synthase activity", "diphosphoglyceromutase activity", "2,3-diphosphoglyceromutase activity", "bisphosphoglycerate synthase activity", "bisphosphoglyceromutase", "2,3-bisphosphoglycerate synthase activity", "3-phospho-D-glycerate 1,2-phosphomutase activity", "diphosphoglyceric mutase activity", "2,3-diphosphoglycerate mutase activity", "2,3-diphosphoglycerate synthase activity", "2,3-bisphosphoglycerate mutase activity", "glycerate phosphomutase activity", "DPGM", "diphosphoglycerate mutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. [EC:5.4.2.4]", "canonical_name": "BPGM activity"}
{"concept_id": "C1150362", "aliases": ["acetylglucosamine phosphomutase activity", "phospho-N-acetylglucosamine mutase activity", "phosphoacetylglucosamine mutase activity", "N-acetylglucosamine-phosphate mutase activity", "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity", "acetylaminodeoxyglucose phosphomutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. [EC:5.4.2.3, RHEA:23804]", "canonical_name": "N-acetyl-D-glucosamine 1,6-phosphomutase activity"}
{"concept_id": "C1150363", "aliases": ["glucose phosphomutase activity", "alpha-D-glucose 1,6-phosphomutase activity", "phosphoglucose mutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. [EC:5.4.2.2]", "canonical_name": "phosphoglucomutase activity"}
{"concept_id": "C1150364", "aliases": ["alpha-D-glucosamine 1,6-phosphomutase activity", "D-glucosamine 1,6-phosphomutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. [EC:5.4.2.10, RHEA:23424]", "canonical_name": "phosphoglucosamine mutase activity"}
{"concept_id": "C1150365", "aliases": ["D-phosphoglycerate 2,3-phosphomutase activity", "monophosphoglycerate mutase activity", "PGM", "MPGM", "PGA mutase activity", "monophosphoglyceromutase activity", "phosphoglyceromutase activity", "phosphoglycerate phosphomutase activity", "phosphoglycerate mutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. [EC:5.4.2.1]", "canonical_name": "PGAM activity"}
{"concept_id": "C1150366", "aliases": ["PGAM-d", "glycerate phosphomutase (diphosphoglycerate cofactor) activity"], "types": ["T044"], "canonical_name": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity", "definition": "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate. [EC:5.4.2.1]"}
{"concept_id": "C1150367", "aliases": ["PGAM-i"], "types": ["T044"], "canonical_name": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity", "definition": "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate. [EC:5.4.2.1]"}
{"concept_id": "C1150368", "aliases": ["D-mannose 1,6-phosphomutase activity", "phosphomannose mutase activity", "alpha-D-mannose 1,6-phosphomutase activity", "mannose phosphomutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. [EC:5.4.2.8, RHEA:11140]", "canonical_name": "phosphomannomutase activity"}
{"concept_id": "C1150369", "aliases": ["alpha-D-ribose 1,5-phosphomutase activity", "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity", "phosphopentomutase activity", "D-ribose 1,5-phosphomutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate. [EC:5.4.2.7]", "canonical_name": "phosphoribomutase activity"}
{"concept_id": "C1150370", "aliases": [], "types": ["T044"], "canonical_name": "intramolecular transferase activity, transferring acyl groups", "definition": "Catalysis of the transfer of an acyl group from one position to another within a single molecule. [GOC:mah]"}
{"concept_id": "C1150371", "aliases": ["precorrin isomerase activity", "precorrin-8X methylmutase activity", "precorrin-8X 11,12-methylmutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate. [EC:5.4.99.61]", "canonical_name": "HBA synthase activity"}
{"concept_id": "C1150372", "aliases": [], "types": ["T044"], "canonical_name": "intramolecular transferase activity, transferring amino groups", "definition": "Catalysis of the transfer of an amino group from one position to another within a single molecule. [GOC:mah]"}
{"concept_id": "C1150373", "aliases": ["(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity", "glutamate-1-semialdehyde 2,1-aminomutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. [EC:5.4.3.8, RHEA:14265]", "canonical_name": "glutamate-1-semialdehyde aminotransferase activity"}
{"concept_id": "C1150374", "aliases": [], "types": ["T044"], "canonical_name": "intramolecular transferase activity, transferring other groups", "definition": "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized. [GOC:ai]"}
{"concept_id": "C1150375", "aliases": [], "types": ["T044"], "canonical_name": "alpha-amyrin synthase activity", "definition": "Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin. [GOC:jl, MetaCyc:RXN-8434, PMID:10848960]"}
{"concept_id": "C1150376", "aliases": ["oxidosqualene:beta-amyrin cyclase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin. [PMID:9746369]", "canonical_name": "beta-amyrin synthase activity"}
{"concept_id": "C1150377", "aliases": ["chorismate mutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: chorismate = prephenate. [EC:5.4.99.5, RHEA:13897]", "canonical_name": "chorismate pyruvatemutase activity"}
{"concept_id": "C1150378", "aliases": ["(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)", "squalene-2,3-epoxide-cycloartenol cyclase activity", "oxidosqualene:cycloartenol cyclase activity", "cycloartenol synthase activity", "2,3-epoxysqualene--cycloartenol cyclase activity", "2,3-oxidosqualene-cycloartenol cyclase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol. [EC:5.4.99.8, RHEA:21308]", "canonical_name": "2,3-epoxysqualene cycloartenol-cyclase activity"}
{"concept_id": "C1150379", "aliases": ["isochorismate mutase activity", "isochorismate synthetase activity", "isochorismate hydroxymutase activity"], "types": ["T044"], "canonical_name": "isochorismate synthase activity", "definition": "Catalysis of the reaction: chorismate = isochorismate. [EC:5.4.4.2, RHEA:18985]"}
{"concept_id": "C1150380", "aliases": ["lanosterol 2,3-oxidosqualene cyclase activity", "squalene 2,3-epoxide:lanosterol cyclase activity", "oxidosqualene-lanosterol cyclase activity", "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)", "squalene-2,3-oxide-lanosterol cyclase activity", "2,3-oxidosqualene-lanosterol cyclase activity", "OSC", "2,3-epoxysqualene lanosterol cyclase activity", "2,3-epoxysqualene-lanosterol cyclase activity", "2,3-epoxysqualene--lanosterol cyclase activity", "lanosterol synthase activity", "oxidosqualene:lanosterol cyclase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. [EC:5.4.99.7, RHEA:14621]", "canonical_name": "oxidosqualene--lanosterol cyclase activity"}
{"concept_id": "C1150381", "aliases": ["oxidosqualene:lupeol cyclase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol. [MetaCyc:RXN-111, PMID:9883589]", "canonical_name": "lupeol synthase activity"}
{"concept_id": "C1150382", "aliases": ["methylmalonyl coenzyme A mutase activity", "methylmalonyl-CoA CoA-carbonyl mutase activity", "(S)-methylmalonyl-CoA mutase activity", "methylmalonyl-CoA mutase activity", "methylmalonyl coenzyme A carbonylmutase activity", "(R)-methylmalonyl-CoA CoA-carbonylmutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA. [EC:5.4.99.2, RHEA:22888]", "canonical_name": "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity"}
{"concept_id": "C1150383", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-pseudouridine synthase I activity"}
{"concept_id": "C1150384", "aliases": ["UDP-D-galactopyranose furanomutase activity", "UDPgalactopyranose mutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose. [EC:5.4.99.9]", "canonical_name": "UDP-galactopyranose mutase activity"}
{"concept_id": "C1150385", "aliases": [], "types": ["T044"], "canonical_name": "other isomerase activity", "definition": "OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized. [GOC:ai]"}
{"concept_id": "C1150386", "aliases": [], "types": ["T045"], "definition": "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. [GOC:mah, PMID:8811192]", "canonical_name": "DNA topoisomerase activity"}
{"concept_id": "C1150387", "aliases": ["DNA topoisomerase (ATP-hydrolysing)", "DNA topoisomerase type II activity"], "types": ["T045"], "definition": "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. [PMID:8811192]", "canonical_name": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"}
{"concept_id": "C1150388", "aliases": ["type I topoisomerase activity", "type I DNA topoisomerase activity", "DNA topoisomerase I activity"], "types": ["T045"], "definition": "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. [PMID:8811192]", "canonical_name": "DNA topoisomerase type I (single strand cut, ATP-independent) activity"}
{"concept_id": "C1150390", "aliases": ["phosphoheptose isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate. [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969]", "canonical_name": "D-sedoheptulose 7-phosphate isomerase activity"}
{"concept_id": "C1150391", "aliases": [], "types": ["T044"], "canonical_name": "racemase and epimerase activity", "definition": "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1150392", "aliases": [], "types": ["T044"], "canonical_name": "racemase and epimerase activity, acting on amino acids and derivatives", "definition": "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. [GOC:mah]"}
{"concept_id": "C1150393", "aliases": ["alanine racemase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-alanine = D-alanine. [EC:5.1.1.1, RHEA:20249]", "canonical_name": "L-alanine racemase activity"}
{"concept_id": "C1150394", "aliases": ["LL-2,6-diaminoheptanedioate 2-epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate. [EC:5.1.1.7, RHEA:15393]", "canonical_name": "diaminopimelate epimerase activity"}
{"concept_id": "C1150395", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamate = D-glutamate. [EC:5.1.1.3, RHEA:12813]", "canonical_name": "glutamate racemase activity"}
{"concept_id": "C1150396", "aliases": ["isopenicillin-N epimerase activity", "isopenicillin N epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: isopenicillin N = penicillin N. [EC:5.1.1.17, RHEA:20033]", "canonical_name": "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity"}
{"concept_id": "C1150397", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: L-lysine = D-lysine. [EC:5.1.1.5]", "canonical_name": "lysine racemase activity"}
{"concept_id": "C1150398", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: L-methionine = D-methionine. [EC:5.1.1.2, RHEA:12492]", "canonical_name": "methionine racemase activity"}
{"concept_id": "C1150399", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: L-proline = D-proline. [EC:5.1.1.4, RHEA:10680]", "canonical_name": "proline racemase activity"}
{"concept_id": "C1150400", "aliases": ["protein-serine epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine. [EC:5.1.1.16]", "canonical_name": "protein-serine racemase activity"}
{"concept_id": "C1150401", "aliases": [], "types": ["T044"], "definition": "Catalysis of the synthesis of free D-serine from L-serine. [GOC:kd]", "canonical_name": "serine racemase activity"}
{"concept_id": "C1150402", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: L-threonine = D-threonine. [EC:5.1.1.6, RHEA:13913]", "canonical_name": "threonine racemase activity"}
{"concept_id": "C1150403", "aliases": [], "types": ["T044"], "canonical_name": "racemase and epimerase activity, acting on carbohydrates and derivatives", "definition": "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. [GOC:mah]"}
{"concept_id": "C1150404", "aliases": ["ADP-glyceromanno-heptose 6-epimerase activity", "ADPglyceromanno-heptose 6-epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. [EC:5.1.3.20, RHEA:17577]", "canonical_name": "ADP-L-glycero-D-manno-heptose 6-epimerase activity"}
{"concept_id": "C1150405", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. [EC:5.1.3.3]", "canonical_name": "aldose 1-epimerase activity"}
{"concept_id": "C1150406", "aliases": ["dTDP-4-dehydrorhamnose 3,5-epimerase activity", "TDP-4-ketorhamnose 3,5-epimerase activity", "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity", "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose. [EC:5.1.3.13, RHEA:16969]", "canonical_name": "TDP-4-keto-L-rhamnose-3,5-epimerase activity"}
{"concept_id": "C1150407", "aliases": ["L-ru5P activity", "ribulose phosphate 4-epimerase activity", "AraD", "L-ribulose-5-phosphate 4-epimerase", "L-ribulose-phosphate 4-epimerase activity", "L-Ru5P", "phosphoribulose isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate. [EC:5.1.3.4, RHEA:22368]", "canonical_name": "L-ribulose 5-phosphate 4-epimerase activity"}
{"concept_id": "C1150408", "aliases": ["erythrose-4-phosphate isomerase activity", "D-ribulose 5-phosphate epimerase activity", "phosphoketopentose epimerase activity", "ribulose-phosphate 3-epimerase activity", "xylulose phosphate 3-epimerase activity", "D-ribulose-5-phosphate epimerase activity", "D-ribulose-5-P 3-epimerase activity", "D-xylulose-5-phosphate 3-epimerase activity", "phosphoketopentose 3-epimerase activity", "D-ribulose phosphate-3-epimerase activity", "ribulose 5-phosphate 3-epimerase activity", "pentose-5-phosphate 3-epimerase activity", "D-ribulose-phosphate 3-epimerase activity", "D-ribulose-5-phosphate 3-epimerase activity", "phosphoribulose epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. [EC:5.1.3.1, RHEA:13677]", "canonical_name": "erythrose-4-phosphate epimerase activity"}
{"concept_id": "C1150409", "aliases": ["uridine diphosphoglucose epimerase activity", "UDPglucose 4-epimerase activity", "uridine diphosphate galactose 4-epimerase activity", "uridine diphosphate glucose 4-epimerase activity", "UDP-glucose epimerase activity", "uridine diphosphoglucose 4-epimerase activity", "4-epimerase activity", "uridine diphospho-galactose-4-epimerase activity", "UDPG-4-epimerase activity", "UDP-D-galactose 4-epimerase activity", "UDP-galactose 4-epimerase activity", "UDPgalactose 4-epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose = UDP-galactose. [EC:5.1.3.2]", "canonical_name": "UDP-glucose 4-epimerase activity"}
{"concept_id": "C1150410", "aliases": ["uridine diphosphate-N-acetylglucosamine-2'-epimerase activity", "UDP-N-acetyl-D-glucosamine 2-epimerase activity", "UDP-N-acetylglucosamine 2'-epimerase activity", "uridine diphosphoacetylglucosamine 2'-epimerase activity", "uridine diphospho-N-acetylglucosamine 2'-epimerase activity", "UDP-GlcNAc-2-epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. [EC:5.1.3.14]", "canonical_name": "UDP-N-acetylglucosamine 2-epimerase activity"}
{"concept_id": "C1150411", "aliases": ["UDP acetylglucosamine epimerase activity", "UDP-N-acetylglucosamine 4-epimerase activity", "UDP-N-acetyl-D-glucosamine 4-epimerase activity", "UDP-GlcNAc 4-epimerase activity", "uridine diphosphoacetylglucosamine epimerase activity", "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine. [EC:5.1.3.7]", "canonical_name": "uridine diphosphate N-acetylglucosamine-4-epimerase activity"}
{"concept_id": "C1150412", "aliases": [], "types": ["T044"], "canonical_name": "racemase and epimerase activity, acting on hydroxy acids and derivatives", "definition": "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule. [GOC:mah]"}
{"concept_id": "C1150413", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity", "definition": "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate. [UM-BBD_reactionID:r0502]"}
{"concept_id": "C1150414", "aliases": ["3-hydroxybutyryl-CoA epimerase activity", "3-hydroxybutyryl coenzyme A epimerase activity", "3-hydroxybutanoyl-CoA 3-epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. [EC:5.1.2.3]", "canonical_name": "3-hydroxyacyl-CoA epimerase activity"}
{"concept_id": "C1150415", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: D-carnitine = L-carnitine. [MetaCyc:CARNRACE-RXN]", "canonical_name": "carnitine racemase activity"}
{"concept_id": "C1150417", "aliases": [], "types": ["T044"], "canonical_name": "cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity", "definition": "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. [UM-BBD_reactionID:r0163]"}
{"concept_id": "C1150418", "aliases": ["maleylacetoacetate isomerase activity", "maleylacetone isomerase activity", "maleylacetone cis-trans-isomerase activity", "maleylacetoacetic isomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. [EC:5.2.1.2]", "canonical_name": "4-maleylacetoacetate cis-trans-isomerase activity"}
{"concept_id": "C1150419", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-mandelate = (R)-mandelate. [EC:5.1.2.2]", "canonical_name": "mandelate racemase activity"}
{"concept_id": "C1150420", "aliases": [], "types": ["T044"], "canonical_name": "racemase and epimerase activity, acting on other compounds", "definition": "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives. [GOC:ai]"}
{"concept_id": "C1150421", "aliases": ["alpha-methylacyl-CoA racemase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA. [EC:5.1.99.4]", "canonical_name": "2-methylacyl-CoA 2-epimerase activity"}
{"concept_id": "C1150422", "aliases": ["methylmalonyl-CoA racemase activity", "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity", "methylmalonyl-CoA 2-epimerase activity", "methylmalonyl coenzyme A racemase activity", "methylmalonyl-CoA epimerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA. [EC:5.1.99.1, RHEA:20553]", "canonical_name": "DL-methylmalonyl-CoA racemase activity"}
{"concept_id": "C1150423", "aliases": ["phosphokinase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732]", "canonical_name": "kinase activity"}
{"concept_id": "C1150424", "aliases": ["inositol-trisphosphate 3-kinase activity", "inositol-1,4,5-trisphosphate 3-kinase activity", "IP3 3-kinase activity", "ins(1,4,5)P(3) 3-kinase activity", "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity", "IP3K activity", "Ins(1,4,5)P3 3-kinase activity", "1D-myo-inositol-trisphosphate 3-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). [EC:2.7.1.127, RHEA:11020]", "canonical_name": "inositol trisphosphate 3-kinase activity"}
{"concept_id": "C1150425", "aliases": ["2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity", "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity", "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity", "H2-pteridine-CH2OH pyrophosphokinase activity", "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity", "HPPK", "hydroxymethyldihydropteridine pyrophosphokinase activity", "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity", "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity", "7,8-dihydroxymethylpterin-pyrophosphokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+). [EC:2.7.6.3, RHEA:11412]", "canonical_name": "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity"}
{"concept_id": "C1150427", "aliases": ["AckA", "acetic kinase activity", "ATP:acetate phosphotransferase activity", "acetate kinase activity", "acetate kinase (phosphorylating) activity", "acetokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate. [EC:2.7.2.1]", "canonical_name": "AK activity"}
{"concept_id": "C1150428", "aliases": ["N-acetylglutamate phosphokinase activity", "acetylglutamate phosphokinase activity", "N-acetylglutamic 5-phosphotransferase activity", "N-acetylglutamate kinase activity", "acetylglutamate kinase activity", "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate. [EC:2.7.2.8]", "canonical_name": "N-acetylglutamate 5-phosphotransferase activity"}
{"concept_id": "C1150429", "aliases": ["adenylylsulfate kinase activity", "adenylyl-sulfate kinase activity", "ATP:adenylyl-sulfate 3'-phosphotransferase activity", "5'-phosphoadenosine sulfate kinase activity", "adenosine-5'-phosphosulfate-3'-phosphokinase activity", "adenosine-5'-phosphosulfate 3'-phosphotransferase activity", "adenosine phosphosulfate kinase activity", "APS kinase activity", "adenosine 5'-phosphosulfate kinase activity", "adenosine phosphosulfokinase activity", "adenosine-5'-phosphosulphate 3'-phosphotransferase activity", "adenylyl-sulphate kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate. [EC:2.7.1.25]", "canonical_name": "adenylylsulfate kinase (phosphorylating)"}
{"concept_id": "C1150430", "aliases": [], "types": ["T044"], "canonical_name": "amino acid kinase activity", "definition": "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate. [GOC:jl]"}
{"concept_id": "C1150431", "aliases": ["arginine phosphokinase activity", "ATP:L-arginine N-phosphotransferase activity", "adenosine 5'-triphosphate-arginine phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+). [EC:2.7.3.3, RHEA:22940]", "canonical_name": "arginine kinase activity"}
{"concept_id": "C1150432", "aliases": ["histone-arginine kinase activity"], "types": ["T044"], "canonical_name": "histone arginine kinase activity", "definition": "Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+). [GOC:mah]"}
{"concept_id": "C1150433", "aliases": ["aspartic kinase activity", "aspartate kinase activity", "ATP:L-aspartate 4-phosphotransferase activity", "beta-aspartokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+). [EC:2.7.2.4, RHEA:23776]", "canonical_name": "aspartokinase activity"}
{"concept_id": "C1150434", "aliases": ["glutamate 5-kinase activity", "ATP-L-glutamate 5-phosphotransferase activity", "ATP:L-glutamate 5-phosphotransferase activity", "gamma-glutamate kinase activity", "glutamate kinase activity", "gamma-glutamyl kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+). [EC:2.7.2.11, RHEA:14877]", "canonical_name": "ATP:gamma-L-glutamate phosphotransferase activity"}
{"concept_id": "C1150435", "aliases": ["homoserine kinase (phosphorylating)", "HSK", "ATP:L-homoserine O-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+). [EC:2.7.1.39, RHEA:13985]", "canonical_name": "homoserine kinase activity"}
{"concept_id": "C1150436", "aliases": ["carbamoyl phosphokinase activity", "carbamate kinase activity", "CKase activity", "ATP:carbamate phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate. [EC:2.7.2.2]", "canonical_name": "carbamyl phosphokinase activity"}
{"concept_id": "C1150437", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate kinase activity", "definition": "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. [GOC:jl]"}
{"concept_id": "C1150438", "aliases": ["2-keto-3-deoxygalactonokinase activity", "2-keto-3-deoxygalactonate kinase (phosphorylating)", "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity", "2-keto-3-deoxy-galactonokinase activity", "2-oxo-3-deoxygalactonate kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H(+). [EC:2.7.1.58, RHEA:16525]", "canonical_name": "2-dehydro-3-deoxygalactonokinase activity"}
{"concept_id": "C1150439", "aliases": ["2-keto-3-deoxygluconate kinase activity", "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity", "2-dehydro-3-deoxygluconokinase activity", "2-keto-3-deoxygluconokinase activity", "2-keto-3-deoxygluconokinase (phosphorylating)", "3-deoxy-2-oxo-D-gluconate kinase activity", "2-keto-3-deoxy-D-gluconic acid kinase activity", "ketodeoxygluconokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H(+). [EC:2.7.1.45, RHEA:14797]", "canonical_name": "KDG kinase activity"}
{"concept_id": "C1150440", "aliases": ["D-allose-6-kinase activity", "ATP:D-allose 6-phosphotransferase activity", "allokinase activity", "D-allokinase activity", "allokinase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate. [EC:2.7.1.55]", "canonical_name": "allose kinase activity"}
{"concept_id": "C1150441", "aliases": ["D-ribulokinase (phosphorylating)", "D-ribulokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate. [EC:2.7.1.47]", "canonical_name": "ATP:D-ribulose 5-phosphotransferase activity"}
{"concept_id": "C1150442", "aliases": ["ATP:D-fructose 6-phosphotransferase activity", "fructokinase activity", "fructokinase (phosphorylating)", "D-fructokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. [EC:2.7.1.4]", "canonical_name": "D-fructose(D-mannose)kinase activity"}
{"concept_id": "C1150443", "aliases": ["galactokinase (phosphorylating)", "ATP:D-galactose-1-phosphotransferase activity", "ATP:D-galactose 1-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+). [EC:2.7.1.6, RHEA:13553]", "canonical_name": "galactokinase activity"}
{"concept_id": "C1150444", "aliases": ["glucokinase (phosphorylating)", "ATP:D-glucose 6-phosphotransferase activity", "glucose kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. [EC:2.7.1.2]", "canonical_name": "glucokinase activity"}
{"concept_id": "C1150445", "aliases": ["hexokinase activity", "hexokinase D", "ATP-dependent hexokinase activity", "hexokinase type IV (glucokinase) activity", "hexokinase type IV", "hexokinase (phosphorylating)", "ATP:D-hexose 6-phosphotransferase activity", "hexokinase type IV glucokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. [EC:2.7.1.1]", "canonical_name": "glucose ATP phosphotransferase activity"}
{"concept_id": "C1150446", "aliases": ["ketohexokinase activity", "ATP:D-fructose 1-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate. [EC:2.7.1.3]", "canonical_name": "ketohexokinase (phosphorylating)"}
{"concept_id": "C1150447", "aliases": ["L-arabinokinase (phosphorylating)", "L-arabinokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H(+). [EC:2.7.1.46, RHEA:20153]", "canonical_name": "ATP:L-arabinose 1-phosphotransferase activity"}
{"concept_id": "C1150448", "aliases": ["L-fuculokinase (phosphorylating)", "ATP:L-fuculose 1-phosphotransferase activity", "L-fuculose kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+). [EC:2.7.1.51, RHEA:12376]", "canonical_name": "L-fuculokinase activity"}
{"concept_id": "C1150449", "aliases": ["ATP:L(or D)-ribulose 5-phosphotransferase activity", "ribulokinase (phosphorylating)", "L-ribulokinase activity"], "types": ["T044"], "canonical_name": "ribulokinase activity", "definition": "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. [EC:2.7.1.16]"}
{"concept_id": "C1150450", "aliases": ["2-acetylamino-2-deoxy-D-glucose kinase activity", "ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity", "acetylglucosamine kinase (phosphorylating)", "ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity", "acetylaminodeoxyglucokinase activity", "N-acetylglucosamine kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+). [EC:2.7.1.59, RHEA:17417]", "canonical_name": "GlcNAc kinase activity"}
{"concept_id": "C1150451", "aliases": ["acetylmannosamine kinase activity", "acylmannosamine kinase activity", "acetylamidodeoxymannokinase activity", "N-acetylmannosamine kinase activity", "N-acylmannosamine kinase activity", "acylmannosamine kinase (phosphorylating)", "acylaminodeoxymannokinase activity", "N-acyl-D-mannosamine kinase activity", "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. [EC:2.7.1.60]", "canonical_name": "ATP:N-acetylmannosamine 6-phosphotransferase activity"}
{"concept_id": "C1150452", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. [GOC:jl]", "canonical_name": "phosphofructokinase activity"}
{"concept_id": "C1150453", "aliases": ["1-phosphofructokinase activity", "ATP:D-fructose-phosphate 6-phosphotransferase activity", "fructose 1-phosphate kinase activity", "fructose-1-phosphate kinase activity", "phosphofructokinase 1", "1-phosphofructokinase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate. [EC:2.7.1.56]", "canonical_name": "D-fructose-1-phosphate kinase activity"}
{"concept_id": "C1150454", "aliases": ["6-phosphofructose 2-kinase activity", "ATP:D-fructose-6-phosphate 2-phosphotransferase activity", "6-phosphofructo-2-kinase activity", "phosphofructokinase 2 activity", "fructose 6-phosphate 2-kinase activity", "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). [EC:2.7.1.105, RHEA:15653]", "canonical_name": "6-phosphofructo-2-kinase (phosphorylating)"}
{"concept_id": "C1150455", "aliases": ["6-phosphofructose 1-kinase activity", "ATP-dependent phosphofructokinase activity", "6-phosphofructokinase activity", "phosphofructokinase (phosphorylating)", "PFK", "6-phosphofructokinase reduction", "nucleotide triphosphate-dependent phosphofructokinase activity", "phospho-1,6-fructokinase activity", "phosphofructokinase I activity", "ATP:D-fructose-6-phosphate 1-phosphotransferase activity", "D-fructose-6-phosphate 1-phosphotransferase activity", "fructose 6-phosphokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. [EC:2.7.1.11]", "canonical_name": "fructose 6-phosphate kinase activity"}
{"concept_id": "C1150456", "aliases": ["L-rhamnulokinase activity", "L-rhamnulose kinase activity", "rhamnulose kinase activity", "RhuK", "ATP:L-rhamnulose 1-phosphotransferase activity", "rhamnulokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate. [EC:2.7.1.5]", "canonical_name": "rhamnulokinase (phosphorylating)"}
{"concept_id": "C1150457", "aliases": ["phosphoribosylpyrophosphate synthetase activity", "phosphoribosyl-diphosphate synthetase activity", "5-phosphoribose pyrophosphorylase activity", "ribose-5-phosphate pyrophosphokinase activity", "phosphoribosyl diphosphate synthetase activity", "ribose-phosphate diphosphokinase activity", "PP-ribose P synthetase activity", "PRPP synthetase activity", "ATP:D-ribose-5-phosphate diphosphotransferase activity", "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity", "5-phosphoribosyl-1-pyrophosphate synthetase activity", "ribose-phosphate pyrophosphokinase activity", "ribose phosphate diphosphokinase activity", "ribophosphate pyrophosphokinase activity", "pyrophosphoribosylphosphate synthetase activity", "phosphoribosyl pyrophosphate synthetase activity", "PPRibP synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). [EC:2.7.6.1, RHEA:15609]", "canonical_name": "phosphoribosylpyrophosphate synthase activity"}
{"concept_id": "C1150458", "aliases": ["xylulose kinase activity", "ATP:D-xylulose 5-phosphotransferase activity", "xylulokinase activity", "xylulokinase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+). [EC:2.7.1.17, RHEA:10964]", "canonical_name": "D-xylulokinase activity"}
{"concept_id": "C1150459", "aliases": ["L-xylulokinase (phosphorylating)", "ATP:L-xylulose 5-phosphotransferase activity", "L-xylulokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate. [EC:2.7.1.53]", "canonical_name": "L-xylulose kinase activity"}
{"concept_id": "C1150460", "aliases": ["choline phosphokinase activity", "choline-ethanolamine kinase activity", "choline kinase activity", "choline kinase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+). [EC:2.7.1.32, RHEA:12837]", "canonical_name": "ATP:choline phosphotransferase activity"}
{"concept_id": "C1150461", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate. [http://www.mblab.gla.ac.uk/, PMID:1655696]", "canonical_name": "cobinamide kinase activity"}
{"concept_id": "C1150462", "aliases": ["creatine phosphokinase activity", "MM-CK", "creatine phosphotransferase activity", "ATP:creatine phosphotransferase activity", "CKMiMi", "creatine kinase activity", "Mi-CK", "phosphocreatine kinase activity", "CK-BB", "CK", "CK-MB", "ATP:creatine N-phosphotransferase activity", "adenosine triphosphate-creatine transphosphorylase activity", "CK-MM", "MB-CK"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). [EC:2.7.3.2, RHEA:17157]", "canonical_name": "BB-CK"}
{"concept_id": "C1150463", "aliases": ["sphingosine kinase activity"], "types": ["T044"], "canonical_name": "D-erythro-sphingosine kinase activity", "definition": "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. [MetaCyc:RXN3DJ-11417]"}
{"concept_id": "C1150464", "aliases": ["ATP:dephospho-CoA 3'-phosphotransferase activity", "dephospho-CoA kinase activity", "dephosphocoenzyme A kinase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+). [EC:2.7.1.24, RHEA:18245]", "canonical_name": "3'-dephospho-CoA kinase activity"}
{"concept_id": "C1150465", "aliases": ["arachidonoyl-specific diacylglycerol kinase activity", "DGK activity", "diglyceride kinase activity", "diacylglycerol kinase activity", "1,2-diacylglycerol kinase activity", "sn-1,2-diacylglycerol kinase activity", "DG kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. [EC:2.7.1.107, GOC:elh]", "canonical_name": "1,2-diacylglycerol kinase (phosphorylating)"}
{"concept_id": "C1150466", "aliases": ["diphosphate:purine nucleoside phosphotransferase activity", "diphosphate-dependent nucleoside kinase activity", "diphosphate-purine nucleoside kinase activity", "pyrophosphate-purine nucleoside kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide. [EC:2.7.1.143]", "canonical_name": "pyrophosphate-dependent nucleoside kinase activity"}
{"concept_id": "C1150467", "aliases": ["dolichol phosphokinase activity", "dolichol kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate. [EC:2.7.1.108]", "canonical_name": "CTP:dolichol O-phosphotransferase activity"}
{"concept_id": "C1150468", "aliases": ["ethanolamine kinase activity", "ethanolamine kinase (phosphorylating)", "ethanolamine phosphokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine. [EC:2.7.1.82, RHEA:13069]", "canonical_name": "ATP:ethanolamine O-phosphotransferase activity"}
{"concept_id": "C1150470", "aliases": ["D-glyceric acid kinase activity", "ATP:(R)-glycerate 3-phosphotransferase activity", "D-glycerate kinase activity", "glycerate-3-kinase activity", "glycerate kinase (phosphorylating)", "GK", "glycerate kinase", "D-glycerate 3-kinase activity", "ATP:D-glycerate 2-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+). [EC:2.7.1.31, RHEA:23516]", "canonical_name": "glycerate kinase activity"}
{"concept_id": "C1150471", "aliases": ["ATP:glycerol 3-phosphotransferase activity", "ATP:glycerol-3-phosphotransferase activity", "glycerol kinase (phosphorylating)", "glyceric kinase activity", "GK", "glycerol kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+). [EC:2.7.1.30, RHEA:21644]", "canonical_name": "glycerokinase activity"}
{"concept_id": "C1150472", "aliases": ["ATP:glycerone phosphotransferase activity", "dihydroxyacetone kinase activity", "glycerone kinase activity", "acetol kinase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+). [EC:2.7.1.29, RHEA:15773]", "canonical_name": "acetol kinase activity"}
{"concept_id": "C1150473", "aliases": [], "types": ["T044"], "canonical_name": "histidine phosphotransfer kinase activity", "definition": "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. [PMID:11842140]"}
{"concept_id": "C1150474", "aliases": ["4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity", "hydroxyethylthiazole kinase activity", "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+). [EC:2.7.1.50, RHEA:24212]", "canonical_name": "hydroxyethylthiazole kinase (phosphorylating)"}
{"concept_id": "C1150475", "aliases": ["ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity", "hydroxymethylpyrimidine kinase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H(+). [EC:2.7.1.49, RHEA:23096]", "canonical_name": "hydroxymethylpyrimidine kinase activity"}
{"concept_id": "C1150476", "aliases": ["hygromycin B kinase activity"], "types": ["T044"], "canonical_name": "hygromycin-B kinase activity"}
{"concept_id": "C1150477", "aliases": ["inosine kinase activity", "ATP:inosine 5'-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + inosine = ADP + IMP. [EC:2.7.1.73]", "canonical_name": "inosine kinase (phosphorylating)"}
{"concept_id": "C1150479", "aliases": ["ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity", "PI4-kinase activity", "PI 4-kinase activity", "1-phosphatidylinositol 4-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+). [EC:2.7.1.67, RHEA:19877]", "canonical_name": "PI4K"}
{"concept_id": "C1150480", "aliases": ["ATP:myo-inositol 1-phosphotransferase activity", "inositol-1-kinase (phosphorylating)", "myo-inositol 3-kinase activity"], "types": ["T044"], "canonical_name": "inositol 3-kinase activity", "definition": "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate. [EC:2.7.1.64]"}
{"concept_id": "C1150481", "aliases": ["1-phosphatidylinositol 3-kinase activity", "PI3K", "PI3-kinase activity", "PtdIns-3-kinase activity", "1-phosphatidylinositol-3-kinase activity", "ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). [EC:2.7.1.137, RHEA:12709]", "canonical_name": "Vps34p"}
{"concept_id": "C1150482", "aliases": ["phosphatidylinositol 3-kinase activity, class I"], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase activity, class I", "definition": "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity. [PMID:9759495]"}
{"concept_id": "C1150483", "aliases": ["phosphatidylinositol 3-kinase, class I, catalyst activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase, class I, catalyst activity", "definition": "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. [EC:2.7.1.137]"}
{"concept_id": "C1150484", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase, class I, regulator activity", "definition": "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. [EC:2.7.1.137]"}
{"concept_id": "C1150485", "aliases": ["phosphatidylinositol 3-kinase activity, class II"], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase activity, class II", "definition": "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine. [PMID:9759495]"}
{"concept_id": "C1150486", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase activity, class III", "definition": "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol. [PMID:9759495]"}
{"concept_id": "C1150487", "aliases": ["phosphatidylinositol monophosphate kinase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphate kinase activity", "definition": "Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. [EC:2.7.1.-, PMID:9759495]"}
{"concept_id": "C1150488", "aliases": ["phosphatidylinositol-3-phosphate 5-kinase activity", "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity", "1-phosphatidylinositol-3-phosphate 5-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). [EC:2.7.1.150, RHEA:13609]", "canonical_name": "phosphatidylinositol 3-phosphate 5-kinase activity"}
{"concept_id": "C1150489", "aliases": ["PIP5K", "PtdIns(4)P-5-kinase activity", "phosphatidylinositol-4-phosphate 5-kinase activity", "1-phosphatidylinositol-4-phosphate 5-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). [EC:2.7.1.68, RHEA:14425]", "canonical_name": "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity"}
{"concept_id": "C1150491", "aliases": ["PIP4K", "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity"], "types": ["T044"], "canonical_name": "1-phosphatidylinositol-5-phosphate 4-kinase activity", "definition": "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. [EC:2.7.1.149]"}
{"concept_id": "C1150492", "aliases": ["aminoglycoside 3'-phosphotransferase activity", "kanamycin kinase activity", "neomycin phosphotransferase activity", "APH(3') activity", "neomycin-kanamycin phosphotransferase activity", "ATP:kanamycin 3'-O-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate. [EC:2.7.1.95, RHEA:24256]", "canonical_name": "kanamycin kinase (phosphorylating)"}
{"concept_id": "C1150493", "aliases": [], "types": ["T044"], "canonical_name": "lipid kinase activity", "definition": "Catalysis of the phosphorylation of a simple or complex lipid. [GOC:hjd]"}
{"concept_id": "C1150494", "aliases": ["ceramide kinase activity", "acylsphingosine kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate. [EC:2.7.1.138]", "canonical_name": "ATP:ceramide 1-phosphotransferase activity"}
{"concept_id": "C1150495", "aliases": ["dihydrosphingosine kinase activity", "sphingosine kinase (phosphorylating)", "sphinganine kinase activity", "ATP:sphinganine 1-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. [EC:2.7.1.91]", "canonical_name": "dihydrosphingosine kinase (phosphorylating)"}
{"concept_id": "C1150496", "aliases": ["mevalonate 5-phosphotransferase activity", "mevalonate kinase activity", "mevalonate phosphokinase activity", "mevalonate kinase (phosphorylating)", "ATP:mevalonate 5-phosphotransferase activity", "ATP:(R)-mevalonate 5-phosphotransferase activity", "mevalonic acid kinase activity", "mevalonic kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+). [EC:2.7.1.36, RHEA:17065]", "canonical_name": "MVA kinase activity"}
{"concept_id": "C1150497", "aliases": ["NADK", "nicotinamide adenine dinucleotide kinase activity", "NAD+ kinase activity", "nicotinamide adenine dinucleotide kinase (phosphorylating)", "NAD kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). [EC:2.7.1.23, RHEA:18629]", "canonical_name": "ATP:NAD+ 2'-phosphotransferase activity"}
{"concept_id": "C1150498", "aliases": [], "types": ["T044"], "canonical_name": "nucleobase, nucleoside, nucleotide kinase activity"}
{"concept_id": "C1150499", "aliases": ["GPSI", "GPSII", "GTP pyrophosphokinase activity", "ATP-GTP 3'-diphosphotransferase activity", "guanosine 3',5'-polyphosphate synthase activity", "GTP diphosphokinase activity", "guanosine pentaphosphate synthetase activity", "ATP:GTP 3'-diphosphotransferase activity", "guanosine 5',3'-polyphosphate synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. [EC:2.7.6.5]", "canonical_name": "ppGpp synthetase I activity"}
{"concept_id": "C1150500", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. [GOC:ai]", "canonical_name": "nucleoside kinase activity"}
{"concept_id": "C1150501", "aliases": ["adenosine kinase (phosphorylating)", "adenosine kinase activity", "adenosine 5-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + adenosine = ADP + AMP. [EC:2.7.1.20, PMID:11223943]", "canonical_name": "ATP:adenosine 5'-phosphotransferase activity"}
{"concept_id": "C1150502", "aliases": ["Ms-dNK activity", "ATP:deoxynucleoside 5'-phosphotransferase activity", "D. melanogaster deoxynucleoside kinase activity", "Dm-dNK", "ms-dNK"], "types": ["T044"], "canonical_name": "deoxynucleoside kinase activity", "definition": "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. [EC:2.7.1.145]"}
{"concept_id": "C1150503", "aliases": ["ATP:deoxyadenosine 5'-phosphotransferase activity", "deoxyadenosine kinase activity", "purine-deoxyribonucleoside kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+). [EC:2.7.1.76, RHEA:23452]", "canonical_name": "deoxyadenosine kinase (phosphorylating)"}
{"concept_id": "C1150504", "aliases": ["deoxycytidine kinase activity", "arabinofuranosylcytosine kinase activity", "NTP:deoxycytidine 5'-phosphotransferase activity", "deoxycytidine-cytidine kinase activity", "deoxycytidine kinase (phosphorylating)", "Ara-C kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. [EC:2.7.1.74]", "canonical_name": "2'-deoxycytidine kinase activity"}
{"concept_id": "C1150505", "aliases": ["2'-deoxyguanosine kinase activity", "deoxyguanosine kinase (phosphorylating)", "deoxyguanosine kinase activity", "ATP:deoxyguanosine 5'-phosphotransferase activity", "(dihydroxypropoxymethyl)guanine kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+). [EC:2.7.1.113, RHEA:19201]", "canonical_name": "NTP-deoxyguanosine 5'-phosphotransferase activity"}
{"concept_id": "C1150506", "aliases": ["ATP:thymidine 5'-phosphotransferase activity", "2'-deoxythymidine kinase activity", "deoxythymidine kinase (phosphorylating)", "thymidine kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. [EC:2.7.1.21]", "canonical_name": "thymidine kinase (phosphorylating)"}
{"concept_id": "C1150507", "aliases": ["uridine phosphokinase activity", "uridine monophosphokinase activity", "pyrimidine ribonucleoside kinase activity", "uridine kinase (phosphorylating)", "ATP:uridine 5'-phosphotransferase activity", "uridine kinase reaction", "uridine kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + uridine = ADP + UMP. [EC:2.7.1.48]", "canonical_name": "uridine-cytidine kinase activity"}
{"concept_id": "C1150508", "aliases": ["NDK activity", "nucleotide phosphate kinase activity", "nucleoside-diphosphate kinase activity", "nucleoside 5'-diphosphate kinase activity", "nucleoside diphosphate kinase activity", "nucleoside diphosphokinase activity", "uridine diphosphate kinase activity", "UDP kinase activity", "nucleoside diphosphate (UDP) kinase activity", "ATP:nucleoside-diphosphate phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. [EC:2.7.4.6]", "canonical_name": "nucleoside 5'-diphosphate phosphotransferase activity"}
{"concept_id": "C1150510", "aliases": ["adenylate kinase activity", "5'-AMP-kinase activity", "adenylokinase activity", "ATP:AMP phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + AMP = 2 ADP. [EC:2.7.4.3]", "canonical_name": "adenylic kinase activity"}
{"concept_id": "C1150511", "aliases": ["pyrimidine nucleoside monophosphate kinase activity", "cytidine monophosphate kinase activity", "UMP-CMP kinase activity", "CTP:CMP phosphotransferase activity", "deoxycytidine monophosphokinase activity", "cytidylate kinase activity", "ATP:CMP phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. [EC:2.7.4.14]", "canonical_name": "ATP:UMP-CMP phosphotransferase activity"}
{"concept_id": "C1150512", "aliases": ["ATP:(d)GMP phosphotransferase activity", "5'-GMP kinase activity", "guanosine monophosphate kinase activity", "ATP:GMP phosphotransferase activity", "GMP kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + GMP = ADP + GDP. [EC:2.7.4.8]", "canonical_name": "guanylate kinase activity"}
{"concept_id": "C1150513", "aliases": ["ATP:dTMP phosphotransferase activity", "deoxythymidine 5'-monophosphate kinase activity", "TMPK activity", "dTMP kinase activity", "thymidine 5'-monophosphate kinase activity", "thymidylate monophosphate kinase activity", "thymidylic acid kinase activity", "thymidylic kinase activity", "thymidine monophosphate kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. [EC:2.7.4.9]", "canonical_name": "thymidylate kinase activity"}
{"concept_id": "C1150514", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. [GOC:go_curators]", "canonical_name": "uridylate kinase activity"}
{"concept_id": "C1150515", "aliases": ["pantothenate kinase activity", "D-pantothenate kinase activity", "pantothenate kinase (phosphorylating) activity", "ATP:pantothenate 4'-phosphotransferase activity", "ATP:(R)-pantothenate 4'-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. [EC:2.7.1.33]", "canonical_name": "pantothenic acid kinase activity"}
{"concept_id": "C1150516", "aliases": ["PEP carboxykinase activity", "phosphoenolpyruvate carboxykinase activity", "phosphopyruvate carboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products. [EC:4.1.1.32]", "canonical_name": "PEPCK activity"}
{"concept_id": "C1150517", "aliases": ["ATP:oxaloacetate carboxy-lyase (transphosphorylating)", "phosphoenolpyruvate carboxykinase (ATP) activity", "PEPCK (ATP)", "phosphoenolpyruvate carboxylase (ATP)", "PEPK", "phosphopyruvate carboxylase (ATP)", "phosphopyruvate carboxykinase (adenosine triphosphate)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate. [EC:4.1.1.49, RHEA:18617]", "canonical_name": "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)"}
{"concept_id": "C1150518", "aliases": ["phosphopyruvate carboxykinase (pyrophosphate)", "PEP carboxyphosphotransferase activity", "phosphoenolpyruvic carboxylase (pyrophosphate)", "phosphoenolpyruvate carboxykinase (pyrophosphate) activity", "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)", "phosphopyruvate carboxylase (pyrophosphate)", "phosphoenolpyruvic carboxytransphosphorylase activity", "phosphoenolpyruvate carboxytransphosphorylase activity", "phosphoenolpyruvic carboxykinase (pyrophosphate)", "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)", "phosphoenolpyruvate carboxylase (pyrophosphate)", "phosphoenolpyruvate carboxyphosphotransferase activity"], "types": ["T044"], "canonical_name": "phosphoenolpyruvate carboxykinase (diphosphate) activity", "definition": "Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate. [EC:4.1.1.38, RHEA:22356]"}
{"concept_id": "C1150520", "aliases": ["PEPC", "phosphoenolpyruvate carboxylase activity", "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)", "PEP carboxylase activity", "phosphate:oxaloacetate carboxy-lyase (phosphorylating)", "PEPCase activity", "phosphoenolpyruvic carboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-. [EC:4.1.1.31]", "canonical_name": "phosphopyruvate (phosphate) carboxylase activity"}
{"concept_id": "C1150521", "aliases": ["glycerate 3-phosphate kinase activity", "3-phosphoglycerate kinase activity", "3-PGK", "glycerophosphate kinase activity", "ATP-3-phospho-D-glycerate-1-phosphotransferase activity", "phosphoglycerokinase activity", "PGK", "3-phosphoglycerate phosphokinase activity", "ATP:D-3-phosphoglycerate 1-phosphotransferase activity", "phosphoglyceric acid kinase activity", "phosphoglyceric kinase activity", "3-phosphoglyceric acid phosphokinase activity", "ATP:3-phospho-D-glycerate 1-phosphotransferase activity", "3-phosphoglyceric kinase activity", "3-phosphoglyceric acid kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+). [EC:2.7.2.3, RHEA:14801]", "canonical_name": "phosphoglycerate kinase activity"}
{"concept_id": "C1150522", "aliases": ["ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity", "phosphomethylpyrimidine kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. [EC:2.7.4.7]", "canonical_name": "hydroxymethylpyrimidine phosphokinase activity"}
{"concept_id": "C1150523", "aliases": ["5-phosphomevalonate kinase activity", "phosphomevalonate kinase activity", "mevalonate-5-phosphate kinase activity", "mevalonic acid phosphate kinase activity", "ATP:5-phosphomevalonate phosphotransferase activity", "ATP:(R)-5-phosphomevalonate phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+). [EC:2.7.4.2, RHEA:16341]", "canonical_name": "mevalonate phosphate kinase activity"}
{"concept_id": "C1150524", "aliases": ["ribulose-5-phosphate kinase activity", "ribulose phosphate kinase activity", "phosphoribulokinase activity", "phosphoribulokinase (phosphorylating)", "PRK", "5-phosphoribulose kinase activity", "PRuK", "PKK"], "types": ["T044"], "definition": "Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+). [EC:2.7.1.19, RHEA:19365]", "canonical_name": "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity"}
{"concept_id": "C1150525", "aliases": ["ATP-polyphosphate phosphotransferase activity", "ATP:polyphosphate phosphotransferase activity", "polyphosphate kinase activity", "polyphosphate polymerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). [EC:2.7.4.1]", "canonical_name": "polyphosphoric acid kinase activity"}
{"concept_id": "C1150526", "aliases": ["ATP:propanoate phosphotransferase activity", "TdcD", "propanoate kinase activity", "PduW"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate. [EC:2.7.2.15]", "canonical_name": "propionate kinase activity"}
{"concept_id": "C1150527", "aliases": [], "types": ["T044"], "definition": "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [MetaCyc:PROTEIN-KINASE-RXN]", "canonical_name": "protein kinase activity"}
{"concept_id": "C1150528", "aliases": ["HP165", "EnvZ", "protein kinase (histidine)", "ATP:protein-L-histidine N-phosphotransferase activity", "Sln1p", "HK1", "protein histidine kinase (ambiguous)", "histidine kinase (ambiguous)", "histidine kinase activity", "protein-histidine kinase activity", "histidine protein kinase activity", "protein histidine kinase activity", "protein kinase (histidine) (ambiguous)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. [EC:2.7.13.3, GOC:mah]", "canonical_name": "histidine protein kinase (ambiguous)"}
{"concept_id": "C1150529", "aliases": ["ATP:protein-L-histidine Npi-phosphotransferase activity", "ATP:protein-L-histidine N-pros-phosphotransferase activity", "HK2", "protein histidine pros-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine. [EC:2.7.13.1]", "canonical_name": "protein-histidine pros-kinase activity"}
{"concept_id": "C1150530", "aliases": ["ATP:protein-L-histidine N-tele-phosphotransferase activity", "protein-histidine tele-kinase activity", "protein histidine tele-kinase activity", "ATP:protein-L-histidine Ntau-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine. [EC:2.7.13.2]", "canonical_name": "HK3"}
{"concept_id": "C1150531", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor histidine kinase activity", "definition": "Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. [GOC:lr, GOC:mah]"}
{"concept_id": "C1150532", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane histidine kinase cytokinin receptor activity", "definition": "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. [GOC:lr, GOC:mah]"}
{"concept_id": "C1150533", "aliases": [], "types": ["T044"], "canonical_name": "two-component sensor molecule"}
{"concept_id": "C1150535", "aliases": ["phosphatidylinositol-3-phosphate protein kinase activity"], "types": ["T044"], "definition": "Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah]", "canonical_name": "3-phosphoinositide-dependent protein kinase activity"}
{"concept_id": "C1150536", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent protein serine/threonine kinase activity", "definition": "Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. [GOC:mah]"}
{"concept_id": "C1150537", "aliases": ["calmodulin-dependent protein kinase I activity", "Ca2+/calmodulin-dependent protein kinase kinase activity", "calcium/calmodulin-dependent protein kinase type II activity", "CaM kinase II activity", "Ca2+/CaM-dependent kinase activity", "Ca2+/calmodulin-dependent protein kinase 1 activity", "calmodulin regulated protein kinase activity", "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity", "multifunctional calcium/calmodulin regulated protein kinase activity", "CaMKKbeta", "CaMKII", "Ca2+/calmodulin-dependent protein kinase activity", "Ca2+/calmodulin-dependent protein kinase II activity", "multifunctional calcium- and calmodulin-regulated protein kinase activity", "STK20", "CaMKKalpha", "microtubule-associated protein 2 kinase activity", "calmodulin-dependent protein kinase activity", "CaM kinase activity", "CaMKIV", "CaM-regulated serine/threonine kinase activity", "CAM PKII", "calmodulin-dependent kinase II activity", "Ca2+/calmodulin-dependent protein kinase IV activity", "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity", "Ca2+/calmodulin-dependent protein kinase kinase beta activity", "caldesmon kinase (phosphorylating) activity", "CaMKI", "calcium- and calmodulin-dependent protein kinase activity", "calcium/calmodulin-dependent protein kinase activity"], "types": ["T044"], "definition": "Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. [GOC:mah, PMID:11264466]", "canonical_name": "ATP:caldesmon O-phosphotransferase activity"}
{"concept_id": "C1150540", "aliases": ["ATP:elongation factor 2 phosphotransferase activity", "elongation factor-2 kinase activity", "eEF2 kinase activity", "eEF2K", "calmodulin-dependent protein kinase III activity", "STK19", "elongation factor 2 kinase activity", "Ca/CaM-kinase III activity", "eukaryotic elongation factor 2 kinase activity", "eEF-2 kinase activity", "EF2K"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate. [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN]", "canonical_name": "CaM kinase III activity"}
{"concept_id": "C1150542", "aliases": ["myosin heavy chain kinase activity", "myosin-heavy-chain kinase activity", "calmodulin-dependent myosin heavy chain kinase activity", "myosin heavy-chain kinase activity", "myosin heavy chain kinase A activity", "STK6", "MHCK", "MIHC kinase activity", "ATP:myosin heavy-chain O-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate. [EC:2.7.11.7]", "canonical_name": "ATP:myosin-heavy-chain O-phosphotransferase activity"}
{"concept_id": "C1150543", "aliases": ["MLCK", "myosin light-chain kinase (phosphorylating) activity", "myosin kinase activity", "myosin-light-chain kinase activity", "STK18", "ATP:myosin-light-chain O-phosphotransferase activity", "myosin light-chain kinase", "MLCkase activity", "myosin light chain kinase activity", "ATP:myosin-light-chain O-phosphotransferase", "myosin light-chain kinase (phosphorylating)", "myosin light chain protein kinase activity", "calcium/calmodulin-dependent myosin light chain kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. [EC:2.7.11.18]", "canonical_name": "myosin light-chain kinase activity"}
{"concept_id": "C1150544", "aliases": ["PHK", "glycogen phosphorylase kinase activity", "STK17", "phosphorylase kinase (phosphorylating) activity", "phosphorylase kinase, intrinsic catalyst activity", "phosphorylase B kinase activity", "phosphorylase kinase activity", "dephosphophosphorylase kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. [EC:2.7.11.19]", "canonical_name": "ATP:phosphorylase-b phosphotransferase activity"}
{"concept_id": "C1150546", "aliases": [], "types": ["T044"], "canonical_name": "phosphorylase kinase, intrinsic regulator activity"}
{"concept_id": "C1150552", "aliases": [], "types": ["T044"], "canonical_name": "cyclic nucleotide-dependent protein kinase activity", "definition": "cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah]"}
{"concept_id": "C1150553", "aliases": ["ATP:protein phosphotransferase (cAMP-dependent) activity", "AMPK", "PKA", "cAMP-dependent protein kinase, intrinsic catalyst activity", "3',5'-cAMP-dependent protein kinase activity", "3',5' cAMP-dependent protein kinase activity", "STK22", "cyclic AMP-dependent protein kinase activity", "PKA C", "cAMP-dependent protein kinase activity"], "types": ["T044"], "definition": "cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [EC:2.7.11.11]", "canonical_name": "adenosine 3',5'-cyclophosphate-dependent protein kinase activity"}
{"concept_id": "C1150555", "aliases": ["cyclic AMP-dependent protein kinase regulator activity", "3',5'-cAMP-dependent protein kinase regulator activity", "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity", "3',5' cAMP-dependent protein kinase regulator activity"], "types": ["T044"], "canonical_name": "cAMP-dependent protein kinase regulator activity", "definition": "Modulation of the activity of the enzyme cAMP-dependent protein kinase. [GOC:ai]"}
{"concept_id": "C1150556", "aliases": ["STK23", "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity", "PKG II", "PKG", "cGMP-dependent protein kinase ibeta activity", "3':5'-cyclic GMP-dependent protein kinase activity", "cGMP-dependent protein kinase activity"], "types": ["T044"], "definition": "cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah]", "canonical_name": "ATP:protein phosphotransferase (cGMP-dependent) activity"}
{"concept_id": "C1150557", "aliases": ["Cdk-activating protein kinase activity", "CDK, catalytic subunit activity", "CDK", "ATP:cyclin phosphotransferase activity", "cdk-activating kinase activity", "CDK activity", "cyclin-dependent protein kinase activity", "cyclin-dependent protein kinase, intrinsic catalyst activity"], "types": ["T044"], "definition": "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]", "canonical_name": "cyclin-dependent protein serine/threonine kinase activity"}
{"concept_id": "C1150558", "aliases": ["cdk-activating kinase activity", "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity", "CAK"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK). [GOC:go_curators]", "canonical_name": "cyclin-dependent protein kinase activating kinase activity"}
{"concept_id": "C1150560", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity"}
{"concept_id": "C1150561", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-dependent protein kinase 5 activator activity"}
{"concept_id": "C1150565", "aliases": ["cyclin-dependent protein kinase regulator activity", "cyclin-dependent protein serine/threonine kinase regulator activity"], "types": ["T044"], "definition": "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]", "canonical_name": "cyclin"}
{"concept_id": "C1150566", "aliases": [], "types": ["T044"], "definition": "DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah]", "canonical_name": "DNA-dependent protein kinase activity"}
{"concept_id": "C1150567", "aliases": [], "types": ["T045"], "canonical_name": "eukaryotic translation initiation factor 2alpha kinase activity", "definition": "Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. [GOC:mah, InterPro:IPR015516]"}
{"concept_id": "C1150571", "aliases": ["STK12", "TBK1", "inhibitor of NF-kappaB kinase activity", "IKK-2", "IKK-1", "IKBKA", "IKBKB", "CHUK", "IkappaB kinase activity", "IKK", "ATP:IkappaB protein phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. [EC:2.7.11.10]", "canonical_name": "inhibitor of NFkappaB kinase activity"}
{"concept_id": "C1150572", "aliases": ["nPKC", "PKC", "STK24", "protein kinase C activity", "diacylglycerol-activated phospholipid-dependent protein kinase C activity", "cPKC", "ATP:protein phosphotransferase (diacylglycerol-dependent) activity", "PKC activity", "Pkc1p"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. [EC:2.7.11.13]", "canonical_name": "diacylglycerol-activated phospholipid-dependent PKC activity"}
{"concept_id": "C1150574", "aliases": ["conventional protein kinase C activity", "calcium-dependent PKC activity"], "types": ["T044"], "canonical_name": "calcium-dependent protein kinase C activity", "definition": "Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [EC:2.7.11.13, GOC:mah]"}
{"concept_id": "C1150575", "aliases": ["calcium-independent PKC activity", "novel protein kinase C activity"], "types": ["T044"], "canonical_name": "calcium-independent protein kinase C activity", "definition": "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium. [EC:2.7.11.13, GOC:mah]"}
{"concept_id": "C1150578", "aliases": ["STK16", "G-protein-coupled receptor phosphorylating protein kinase activity", "GRK6", "GPCR phosphorylating protein kinase activity", "G protein coupled receptor phosphorylating protein kinase activity", "GPCRK", "GRK5", "G-protein coupled receptor kinase activity", "ATP:G-protein-coupled receptor phosphotransferase activity", "GPCR kinase activity", "GRK4"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate. [GOC:dph]", "canonical_name": "G protein-coupled receptor kinase activity"}
{"concept_id": "C1150579", "aliases": ["ERK", "ERK2", "mitogen-activated protein kinase activity", "ATP:protein phosphotransferase (MAPKK-activated) activity", "MAPK", "SAPK", "mitogen activated kinase activity", "ERK1"], "types": ["T044"], "definition": "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. [GOC:ma, ISBN:0198547684]", "canonical_name": "MAP kinase activity"}
{"concept_id": "C1150582", "aliases": ["MAPK/ERK kinase kinase activity", "cRaf", "ATP:protein phosphotransferase (MAPKKKK-activated) activity", "STK28", "MEKK", "MAPKKK activity", "MEKK2", "mitogen-activated protein kinase kinase kinase activity", "MAP kinase kinase kinase activity", "REKS", "MLTKb", "MEKK3", "MEKK activity", "MEK kinase activity", "MEKK1", "cMos", "MAP3K", "MLTKa"], "types": ["T044"], "definition": "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. [PMID:9561267]", "canonical_name": "MLTK"}
{"concept_id": "C1150583", "aliases": ["JNK kinase kinase activity", "JNKKK"], "types": ["T044"], "canonical_name": "JUN kinase kinase kinase activity", "definition": "Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). [GOC:bf]"}
{"concept_id": "C1150584", "aliases": ["MAP4K activity", "MAPKKKK"], "types": ["T044"], "canonical_name": "MAP kinase kinase kinase kinase activity", "definition": "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. [GOC:bf, PMID:11790549]"}
{"concept_id": "C1150585", "aliases": ["NF-kappaB-inducing kinase activity"], "types": ["T044"], "definition": "Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK). [PMID:20685151]", "canonical_name": "NIK"}
{"concept_id": "C1150586", "aliases": [], "types": ["T044"], "canonical_name": "SAP kinase activity"}
{"concept_id": "C1150587", "aliases": ["JNK", "SAPK1"], "types": ["T044"], "definition": "Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. [GOC:bf, ISBN:0198506732]", "canonical_name": "JUN kinase activity"}
{"concept_id": "C1150592", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. [GOC:mah, PMID:9822608]", "canonical_name": "ribosomal protein S6 kinase activity"}
{"concept_id": "C1150593", "aliases": ["5'-AMP-activated protein kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. [GOC:mah]", "canonical_name": "AMP-activated protein kinase activity"}
{"concept_id": "C1150594", "aliases": ["transmembrane receptor protein serine/threonine kinase activity", "receptor protein serine/threonine kinase activity"], "types": ["T044"], "definition": "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [EC:2.7.11.30]", "canonical_name": "receptor serine/threonine protein kinase activity"}
{"concept_id": "C1150596", "aliases": ["TGFbeta-activated receptor activity", "TGFbeta receptor activity", "transforming growth factor beta", "transforming growth factor beta receptor activity", "TGFbetaR", "transforming growth factor beta-activated receptor activity"], "types": ["T044"], "definition": "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:mah, GOC:signaling]", "canonical_name": "TGF-beta receptor activity"}
{"concept_id": "C1150597", "aliases": ["activin-activated receptor activity"], "types": ["T044"], "definition": "Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. [GOC:mah, GOC:signaling, ISBN:0198506732]", "canonical_name": "activin receptor activity"}
{"concept_id": "C1150598", "aliases": ["type I activin receptor activity"], "types": ["T044"], "canonical_name": "activin receptor activity, type I", "definition": "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals. [GOC:mah, PMID:8622651]"}
{"concept_id": "C1150599", "aliases": ["type II activin receptor activity"], "types": ["T044"], "canonical_name": "activin receptor activity, type II", "definition": "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor. [GOC:mah, PMID:8622651]"}
{"concept_id": "C1150600", "aliases": ["type I TGF-beta receptor activity", "type I transforming growth factor beta receptor activity", "type I TGFbeta receptor activity"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor activity, type I", "definition": "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals. [GOC:mah, Reactome:R-HSA-170846]"}
{"concept_id": "C1150601", "aliases": ["type II TGFbeta receptor activity", "type II TGF-beta receptor activity", "type II transforming growth factor beta receptor activity"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor activity, type II", "definition": "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor. [GOC:mah, Reactome:R-HSA-170861]"}
{"concept_id": "C1150602", "aliases": ["CTD kinase activity", "STK9", "RNA polymerase II carboxy-terminal domain kinase activity", "RNA polymerase II CTD heptapeptide repeat kinase activity", "[RNA-polymerase]-subunit kinase activity", "RNA polymerase subunit kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. [EC:2.7.11.23, GOC:mah]", "canonical_name": "RNA-polymerase-subunit kinase activity"}
{"concept_id": "C1150603", "aliases": ["dual-specificity kinase activity"], "types": ["T044"], "canonical_name": "dual-specificity protein kinase"}
{"concept_id": "C1150604", "aliases": ["MEK1", "ATP:protein phosphotransferase (MAPKKK-activated) activity", "MAP2K", "STK27", "MAP kinase kinase activity", "MAPK activator activity", "MAPKK activity", "MAPKK1", "mitogen-activated protein kinase kinase activity", "MKK6", "MEK2", "ERK activator kinase activity", "MKK2", "MKK7", "MAPKK", "MKK"], "types": ["T044"], "definition": "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. [ISBN:0198547684]", "canonical_name": "MKK4"}
{"concept_id": "C1150605", "aliases": ["JUN kinase kinase activity"], "types": ["T044"], "definition": "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase. [GOC:bf, PMID:11057897, PMID:11790549]", "canonical_name": "JNKK"}
{"concept_id": "C1150607", "aliases": ["protein-tyrosine kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]", "canonical_name": "protein tyrosine kinase activity"}
{"concept_id": "C1150608", "aliases": ["ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity", "non-membrane spanning protein tyrosine kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. [EC:2.7.10.2]", "canonical_name": "non-specific protein-tyrosine kinase activity"}
{"concept_id": "C1150610", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jid]", "canonical_name": "focal adhesion kinase activity"}
{"concept_id": "C1150612", "aliases": ["receptor protein-tyrosine kinase activity", "receptor protein tyrosine kinase activity"], "types": ["T044"], "canonical_name": "transmembrane receptor protein tyrosine kinase activity", "definition": "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [EC:2.7.10.1, GOC:mah]"}
{"concept_id": "C1150613", "aliases": [], "types": ["T044"], "canonical_name": "boss receptor activity", "definition": "Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [GOC:jl, GOC:signaling]"}
{"concept_id": "C1150614", "aliases": ["Eph receptor activity"], "types": ["T044"], "canonical_name": "ephrin receptor activity", "definition": "Combining with an ephrin receptor ligand to initiate a change in cell activity. [GOC:mah, PMID:9530499]"}
{"concept_id": "C1150615", "aliases": ["GPI-linked Eph receptor activity"], "types": ["T044"], "canonical_name": "GPI-linked ephrin receptor activity", "definition": "Combining with a GPI-anchored ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]"}
{"concept_id": "C1150616", "aliases": ["transmembrane-Eph receptor activity"], "types": ["T044"], "canonical_name": "transmembrane-ephrin receptor activity", "definition": "Combining with a transmembrane ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]"}
{"concept_id": "C1150617", "aliases": ["epidermal growth factor-activated receptor activity", "transforming growth factor-alpha receptor activity", "epidermal growth factor receptor activity", "EGFR", "TGF-alpha receptor activity"], "types": ["T044"], "definition": "Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:bf]", "canonical_name": "EGF receptor activity"}
{"concept_id": "C1150619", "aliases": ["fibroblast growth factor receptor activity", "fibroblast growth factor-activated receptor activity", "FGF-activated receptor activity", "FGFR"], "types": ["T044"], "definition": "Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]", "canonical_name": "FGF receptor activity"}
{"concept_id": "C1150620", "aliases": ["G-CSF receptor activity", "granulocyte colony stimulating factor receptor activity", "granulocyte colony-stimulating factor receptor activity"], "types": ["T044"], "definition": "Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]", "canonical_name": "CSF3R"}
{"concept_id": "C1150621", "aliases": ["granulocyte macrophage colony-stimulating factor receptor activity", "CSF-2 receptor activity", "CSF2R", "GM-CSF receptor activity", "GMC-SF receptor activity"], "types": ["T044"], "definition": "Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]", "canonical_name": "granulocyte macrophage colony stimulating factor receptor activity"}
{"concept_id": "C1150622", "aliases": ["hepatocyte growth factor-activated receptor activity", "hepatocyte growth factor receptor activity", "HGF-activated receptor activity"], "types": ["T044"], "definition": "Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]", "canonical_name": "HGF receptor activity"}
{"concept_id": "C1150623", "aliases": ["insulin receptor activity"], "types": ["T044"], "definition": "Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [ISBN:0198506732]", "canonical_name": "insulin-activated receptor activity"}
{"concept_id": "C1150624", "aliases": ["insulin-like growth factor receptor activity", "insulin-like growth factor-activated receptor activity", "IGF-activated receptor activity"], "types": ["T044"], "definition": "Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]", "canonical_name": "IGF receptor activity"}
{"concept_id": "C1150625", "aliases": ["CSF-1", "Fms", "M-CSF receptor activity", "macrophage colony stimulating factor receptor activity"], "types": ["T044"], "definition": "Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [GOC:mah, GOC:signaling]", "canonical_name": "macrophage colony-stimulating factor receptor activity"}
{"concept_id": "C1150627", "aliases": [], "types": ["T044"], "canonical_name": "Neu/ErbB-2 receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1150628", "aliases": ["neurotrophin TRK receptor activity"], "types": ["T044"], "canonical_name": "neurotrophin TRK receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jid]"}
{"concept_id": "C1150629", "aliases": ["neurotrophin TRKA receptor activity"], "types": ["T044"], "canonical_name": "neurotrophin TRKA receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jid]"}
{"concept_id": "C1150630", "aliases": ["neurotrophin TRKB receptor activity"], "types": ["T044"], "canonical_name": "neurotrophin TRKB receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jid]"}
{"concept_id": "C1150631", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin TRKC receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jid]"}
{"concept_id": "C1150632", "aliases": ["PDGF-activated receptor activity", "platelet-derived growth factor receptor activity", "PDGFR activity", "PDGF receptor activity"], "types": ["T044"], "definition": "Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]", "canonical_name": "platelet-derived growth factor-activated receptor activity"}
{"concept_id": "C1150633", "aliases": ["PDGF alpha-receptor activity", "alphaPDGF receptor activity"], "types": ["T044"], "canonical_name": "platelet-derived growth factor alpha-receptor activity", "definition": "Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity. [PMID:1657917]"}
{"concept_id": "C1150634", "aliases": ["betaPDGF receptor activity", "PDGF beta-receptor activity"], "types": ["T044"], "canonical_name": "platelet-derived growth factor beta-receptor activity", "definition": "Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity. [PMID:1657917]"}
{"concept_id": "C1150635", "aliases": ["KIT", "SCF receptor activity", "stem cell factor receptor activity", "KIT ligand receptor activity"], "types": ["T044"], "definition": "Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. [GOC:jl, GOC:signaling, PMID:10698217]", "canonical_name": "KL receptor activity"}
{"concept_id": "C1150636", "aliases": ["vascular endothelial growth factor E-activated receptor activity", "vascular endothelial growth factor-activated receptor activity", "VEGFR activity", "vascular endothelial growth factor receptor activity", "VEGF-activated receptor activity"], "types": ["T044"], "definition": "Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:19909239]", "canonical_name": "VEGF receptor activity"}
{"concept_id": "C1150637", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor protein kinase activity", "definition": "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. [GOC:mah]"}
{"concept_id": "C1150638", "aliases": ["pyridoxal phosphokinase activity", "pyridoxal 5-phosphate-kinase activity", "pyridoxal kinase activity", "ATP:pyridoxal 5'-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. [EC:2.7.1.35]", "canonical_name": "pyridoxal kinase (phosphorylating)"}
{"concept_id": "C1150639", "aliases": ["PDK", "pyruvate dehydrogenase (acetyl-transferring) kinase activity", "pyruvate dehydrogenase kinase (phosphorylating) activity", "pyruvate dehydrogenase kinase activity", "PDHK"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. [EC:2.7.11.2]", "canonical_name": "PDH kinase activity"}
{"concept_id": "C1150640", "aliases": ["FK", "riboflavine kinase activity", "riboflavin kinase (phosphorylating)", "riboflavin kinase activity", "flavokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+). [EC:2.7.1.26, RHEA:14357]", "canonical_name": "ATP:riboflavin 5'-phosphotransferase activity"}
{"concept_id": "C1150641", "aliases": ["ribokinase (phosphorylating)", "D-ribokinase activity", "ribokinase activity", "ATP:D-ribose 5-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. [EC:2.7.1.15]", "canonical_name": "deoxyribokinase activity"}
{"concept_id": "C1150642", "aliases": ["selenide,water dikinase activity", "selenophosphate synthase activity", "ATP:selenide, water phosphotransferase activity", "selenide, water dikinase activity", "selenophosphate synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate. [EC:2.7.9.3, RHEA:18737]", "canonical_name": "selenium donor protein activity"}
{"concept_id": "C1150643", "aliases": ["ATP:shikimate 3-phosphotransferase activity", "shikimate kinase activity", "shikimate kinase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+). [EC:2.7.1.71, RHEA:13121]", "canonical_name": "shikimate kinase II"}
{"concept_id": "C1150644", "aliases": ["tagatose-6-phosphate kinase activity", "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate. [EC:2.7.1.144]", "canonical_name": "phosphotagatokinase activity"}
{"concept_id": "C1150645", "aliases": ["tetraacyldisaccharide 4'-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H(+) + lipid IV(a). [EC:2.7.1.130, RHEA:20700]", "canonical_name": "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity"}
{"concept_id": "C1150646", "aliases": ["ATP:thiamin pyrophosphotransferase activity", "thiaminokinase activity", "thiamin pyrophosphotransferase activity", "ATP:thiamine diphosphotransferase activity", "thiamin diphosphokinase activity", "TPTase activity", "thiamine pyrophosphokinase activity", "thiamine diphosphokinase activity", "thiamin:ATP pyrophosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. [EC:2.7.6.2]", "canonical_name": "thiamin pyrophosphokinase activity"}
{"concept_id": "C1150647", "aliases": ["thiamin-phosphate kinase activity", "thiamin phosphate kinase activity", "thiamin monophosphokinase activity", "ATP:thiamine-phosphate phosphotransferase activity", "thiamin-monophosphate kinase activity", "thiamin monophosphatase activity", "thiamine-monophosphate kinase activity"], "types": ["T044"], "canonical_name": "thiamine-phosphate kinase activity", "definition": "Catalysis of the reaction: ATP + thiamine phosphate = ADP + H(+) + thiamine diphosphate. [EC:2.7.4.16, RHEA:15913]"}
{"concept_id": "C1150648", "aliases": ["C55-isoprenoid alcohol phosphokinase activity", "undecaprenol kinase activity", "C55-isoprenoid alcohol kinase activity", "ATP:undecaprenol phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate. [EC:2.7.1.66, RHEA:23752]", "canonical_name": "C55-isoprenyl alcohol phosphokinase activity"}
{"concept_id": "C1150649", "aliases": ["pyruvate,water dikinase activity", "phosphopyruvate synthetase activity", "ATP:pyruvate, water phosphotransferase activity", "phosphoenolpyruvic synthase activity", "phoephoenolpyruvate synthetase activity", "water pyruvate dikinase activity", "phosphoenolpyruvate synthase activity", "pyruvate-water dikinase (phosphorylating)", "PEP synthase activity", "pyruvate, water dikinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate. [EC:2.7.9.2, RHEA:11364]", "canonical_name": "PEP synthetase activity"}
{"concept_id": "C1150650", "aliases": ["IDHK/P", "IDH kinase activity", "isocitrate dehydrogenase kinase activity", "IDH-K/P", "isocitrate dehydrogenase (NADP) kinase activity", "[isocitrate dehydrogenase (NADP+)] kinase activity", "isocitrate dehydrogenase kinase (phosphorylating) activity", "isocitrate dehydrogenase (NADP+) kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate. [EC:2.7.11.5]", "canonical_name": "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity"}
{"concept_id": "C1150651", "aliases": ["synthetase activity"], "types": ["T044"], "definition": "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. [GOC:mah]", "canonical_name": "ligase activity"}
{"concept_id": "C1150652", "aliases": ["NBAD hydrolase activity", "N-beta-alanyl-dopamine hydrolase activity"], "types": ["T044"], "canonical_name": "beta-alanyl-dopamine hydrolase activity", "definition": "Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine. [GOC:bf, ISBN:0198506732, PMID:12957543]"}
{"concept_id": "C1150653", "aliases": ["delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity"], "types": ["T044"], "definition": "Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol. [PMID:1572368, PMID:2061333]", "canonical_name": "ACV synthetase activity"}
{"concept_id": "C1150654", "aliases": [], "types": ["T044"], "canonical_name": "ligase activity, forming carbon-carbon bonds", "definition": "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.4.-.-, GOC:jl, GOC:mah]"}
{"concept_id": "C1150655", "aliases": [], "types": ["T044"], "canonical_name": "acetophenone carboxylase activity", "definition": "Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate. [UM-BBD_reactionID:r0033]"}
{"concept_id": "C1150656", "aliases": [], "types": ["T044"], "canonical_name": "CoA carboxylase activity", "definition": "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:mah]"}
{"concept_id": "C1150657", "aliases": ["acetyl coenzyme A carboxylase activity", "acetyl-CoA carboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. [EC:6.4.1.2]", "canonical_name": "acetyl-CoA:carbon-dioxide ligase (ADP-forming)"}
{"concept_id": "C1150659", "aliases": ["propanoyl-CoA:carbon-dioxide ligase (ADP-forming)", "propionyl coenzyme A carboxylase activity", "propionyl-CoA carboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. [EC:6.4.1.3]", "canonical_name": "PCCase activity"}
{"concept_id": "C1150660", "aliases": [], "types": ["T044"], "canonical_name": "phenylphosphate carboxylase activity", "definition": "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate. [UM-BBD_reactionID:r0157]"}
{"concept_id": "C1150661", "aliases": ["pyruvate:carbon-dioxide ligase (ADP-forming)", "pyruvic carboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate. [EC:6.4.1.1, RHEA:20844]", "canonical_name": "pyruvate carboxylase activity"}
{"concept_id": "C1150662", "aliases": [], "types": ["T044"], "canonical_name": "ligase activity, forming carbon-nitrogen bonds", "definition": "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:mah]"}
{"concept_id": "C1150663", "aliases": ["acid-ammonia (or amide) ligase activity"], "types": ["T044"], "definition": "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:jl, GOC:mah]", "canonical_name": "amide synthase activity"}
{"concept_id": "C1150664", "aliases": [], "types": ["T044"], "canonical_name": "ammonia ligase activity", "definition": "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. [GOC:jl]"}
{"concept_id": "C1150665", "aliases": ["aspartate-ammonia ligase activity", "asparagine synthetase activity", "L-aspartate:ammonia ligase (AMP-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine. [EC:6.3.1.1]", "canonical_name": "L-asparagine synthetase activity"}
{"concept_id": "C1150666", "aliases": ["diphthamide synthase activity", "diphthine:ammonia ligase (ADP-forming)", "diphthamide synthetase activity"], "types": ["T044"], "canonical_name": "diphthine-ammonia ligase activity", "definition": "Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate. [EC:6.3.1.14, RHEA:19753]"}
{"concept_id": "C1150667", "aliases": ["L-glutamine synthetase activity", "glutamylhydroxamic synthetase activity", "glutamate-ammonia ligase activity", "glutamine synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate. [EC:6.3.1.2, RHEA:16169]", "canonical_name": "L-glutamate:ammonia ligase (ADP-forming)"}
{"concept_id": "C1150668", "aliases": ["gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity", "glutathione:spermidine ligase (ADP-forming) activity", "GSP synthetase activity", "glutathionylspermidine synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate. [EC:6.3.1.8]", "canonical_name": "glutathionylspermidine synthetase activity"}
{"concept_id": "C1150669", "aliases": ["acid-amino acid ligase activity"], "types": ["T044"], "definition": "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:jl, GOC:mah]", "canonical_name": "peptide synthase activity"}
{"concept_id": "C1150670", "aliases": ["2,3-dihydroxybenzoate-AMP ligase activity", "ATP:2,3-dihydroxybenzoate adenylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate. [EC:2.7.7.58, RHEA:20229]", "canonical_name": "(2,3-dihydroxybenzoyl)adenylate synthase activity"}
{"concept_id": "C1150671", "aliases": ["crotonobetaine/carnitine-CoA ligase activity"], "types": ["T044"], "canonical_name": "crotonobetaine/carnitine-CoA ligase activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1150672", "aliases": ["D-alanylalanine synthetase activity", "D-alanine-D-alanine ligase activity", "D-alanine:D-alanine ligase (ADP-forming)", "alanine:alanine ligase (ADP-forming) activity", "alanylalanine synthetase activity", "D-alanyl-D-alanine synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H(+) + phosphate. [EC:6.3.2.4, RHEA:11224]", "canonical_name": "D-Ala-D-Ala synthetase activity"}
{"concept_id": "C1150673", "aliases": ["7,8-dihydropteroate:L-glutamate ligase (ADP-forming)", "FHFS activity", "dihydrofolate synthetase-folylpolyglutamate synthetase activity", "7,8-dihydropteroate:L-glutamate ligase (ADP) activity", "H(2)-folate synthetase activity", "dihydrofolate synthase activity", "dihydropteroate:L-glutamate ligase (ADP-forming) activity", "H2-folate synthetase activity", "7,8-dihydrofolate synthetase activity", "dihydrofolate synthetase activity", "FHFS/FPGS activity", "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate. [EC:6.3.2.12]", "canonical_name": "DHFS activity"}
{"concept_id": "C1150674", "aliases": ["tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity", "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity", "tetrahydrofolate synthase activity", "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)", "folylpoly(gamma-glutamate) synthase activity", "tetrahydrofolylpolyglutamate synthase activity", "N10-formyltetrahydropteroyldiglutamate synthetase activity", "formyltetrahydropteroyldiglutamate synthetase activity", "N(10)-formyltetrahydropteroyldiglutamate synthetase activity", "folylpoly-gamma-glutamate synthase activity", "folate polyglutamate synthetase activity", "folylpolyglutamyl synthetase activity", "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)", "FPGS activity", "folylpolyglutamate synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). [EC:6.3.2.17]", "canonical_name": "folylpolyglutamate synthase activity"}
{"concept_id": "C1150675", "aliases": ["gamma-glutamylcysteine synthetase activity", "glutamate-cysteine ligase activity", "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity", "gamma-glutamyl-L-cysteine synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. [EC:6.3.2.2, RHEA:13285]", "canonical_name": "gamma-glutamylcysteinyl synthetase activity"}
{"concept_id": "C1150676", "aliases": ["glutathione synthetase activity", "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)", "GSH synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate. [EC:6.3.2.3, RHEA:13557]", "canonical_name": "glutathione synthase activity"}
{"concept_id": "C1150677", "aliases": ["pantothenate synthetase activity", "(R)-pantoate:beta-alanine ligase (AMP-forming)", "D-pantoate:beta-alanine ligase (AMP-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. [EC:6.3.2.1]", "canonical_name": "pantoate-beta-alanine ligase activity"}
{"concept_id": "C1150678", "aliases": ["(R)-4'-phosphopantothenate:L-cysteine ligase activity", "phosphopantothenoylcysteine synthetase activity", "phosphopantothenate--cysteine ligase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. [EC:6.3.2.5]", "canonical_name": "phosphopantothenate-cysteine ligase activity"}
{"concept_id": "C1150680", "aliases": [], "types": ["T044"], "canonical_name": "ribosomal S6-glutamic acid ligase activity", "definition": "Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6. [GOC:mah, PMID:2570347]"}
{"concept_id": "C1150681", "aliases": ["tubulinyl-tyrosine ligase activity", "TTL activity", "alpha-tubulin:L-tyrosine ligase (ADP-forming)"], "types": ["T044"], "canonical_name": "tubulin-tyrosine ligase activity", "definition": "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. [EC:6.3.2.25]"}
{"concept_id": "C1150682", "aliases": ["E3", "ubiquitin-like-protein ligase activity", "ubiquitin-like protein ligase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "canonical_name": "small conjugating protein ligase activity"}
{"concept_id": "C1150683", "aliases": ["RUB1 conjugating enzyme activity"], "types": ["T044"], "canonical_name": "Hub1 conjugating enzyme activity"}
{"concept_id": "C1150684", "aliases": [], "types": ["T044"], "canonical_name": "SMT3 conjugating enzyme"}
{"concept_id": "C1150685", "aliases": ["ubiquitin protein-ligase activity", "ubiquitin protein ligase activity", "E3", "ubiquitin ligase activity", "ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition"], "types": ["T044"], "definition": "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]", "canonical_name": "protein ubiquitination activity"}
{"concept_id": "C1150687", "aliases": ["UDP-Mur-NAC-L-Ala:D-Glu ligase activity", "MurD synthetase activity", "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity", "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity", "UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. [EC:6.3.2.9, RHEA:16429]", "canonical_name": "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)"}
{"concept_id": "C1150688", "aliases": ["UDP-N-acetylmuramyl-tripeptide synthetase activity", "UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity", "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity", "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate. [EC:6.3.2.13, RHEA:23676]", "canonical_name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity"}
{"concept_id": "C1150689", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. [RHEA:28374]", "canonical_name": "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"}
{"concept_id": "C1150691", "aliases": ["carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)", "carbamoyl-phosphate synthetase (ammonia) activity", "carbamoylphosphate synthase activity", "carbamoylphosphate synthase (ammonia)", "carbamylphosphate synthetase activity", "carbon-dioxide--ammonia ligase activity", "carbamoyl-phosphate synthetase I activity", "carbamoylphosphate synthetase (ammonia) activity", "carbamoyl phosphate synthase (ammonia) activity", "carbamoyl-phosphate synthase (ammonia) activity", "CPS I activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate. [EC:6.3.4.16, RHEA:10624]", "canonical_name": "carbmoylphosphate synthetase activity"}
{"concept_id": "C1150692", "aliases": ["carbamoyl phosphate synthetase activity", "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity", "carbamyl phosphate synthetase (glutamine) activity", "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity", "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity", "glutamine-dependent carbamoyl-phosphate synthase activity", "GD-CPSase activity", "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity", "glutamine-dependent carbamyl phosphate synthetase activity", "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity", "CPS activity", "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity", "carbamoylphosphate synthetase II activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. [EC:6.3.5.5, RHEA:18633]", "canonical_name": "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity"}
{"concept_id": "C1150693", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen. [PMID:12360532]", "canonical_name": "carbon-nitrogen ligase activity, with glutamine as amido-N-donor"}
{"concept_id": "C1150694", "aliases": ["asparagine synthetase B activity", "L-aspartate:L-glutamine amido-ligase (AMP-forming)", "asparagine synthase (glutamine-hydrolyzing) activity", "asparagine synthetase (glutamine-hydrolyzing) activity", "glutamine-dependent asparagine synthetase activity", "AS", "asparagine synthase (glutamine-hydrolysing)", "AS-B activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. [EC:6.3.5.4, RHEA:12228]", "canonical_name": "asparagine synthetase (glutamine-hydrolysing)"}
{"concept_id": "C1150695", "aliases": ["Glu-tRNAGln amidotransferase activity", "glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)", "Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)", "glutamyl-tRNAGln amidotransferase activity", "glutaminyl-tRNA synthase (glutamine-hydrolysing)", "glutamyl-tRNA(Gln) amidotransferase activity", "glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "Glu-tRNA(Gln) amidotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]", "canonical_name": "Glu-AdT activity"}
{"concept_id": "C1150696", "aliases": ["guanosine 5'-monophosphate synthetase activity", "guanylate synthetase (glutamine-hydrolyzing)", "GMP synthetase (glutamine-hydrolyzing) activity", "GMP synthetase (glutamine-hydrolysing)", "glutamine amidotransferase activity", "xanthosine 5'-phosphate amidotransferase activity", "GMP synthase (glutamine-hydrolysing)", "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)", "guanosine monophosphate synthetase (glutamine-hydrolyzing)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+). [RHEA:11680]", "canonical_name": "GMP synthase (glutamine-hydrolyzing) activity"}
{"concept_id": "C1150697", "aliases": ["NAD(+) synthetase (glutamine-hydrolyzing) activity", "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)", "NAD+ synthetase (glutamine-hydrolyzing)", "NAD+ synthase (glutamine-hydrolysing)", "desamidonicotinamide adenine dinucleotide amidotransferase activity", "NAD synthetase (glutamine-hydrolysing)", "NAD synthase (glutamine-hydrolyzing) activity", "NAD+ synthase (glutamine-hydrolyzing) activity", "nicotinamide adenine dinucleotide synthetase (glutamine) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. [EC:6.3.5.1]", "canonical_name": "DPN synthetase activity"}
{"concept_id": "C1150698", "aliases": ["FGAM synthase activity", "FGAR amidotransferase activity", "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)", "formylglycinamide ribotide amidotransferase activity", "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)", "FGARAT activity", "formylglycinamide ribonucloetide amidotransferase activity", "phosphoribosylformylglycinamidine synthase activity", "phosphoribosylformylglycinamidine synthetase activity", "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)", "FGAM synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate. [EC:6.3.5.3, RHEA:17129]", "canonical_name": "phosphoribosylformylglycineamidine synthetase activity"}
{"concept_id": "C1150699", "aliases": [], "types": ["T044"], "canonical_name": "cyclo-ligase activity", "definition": "Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:jl, GOC:mah]"}
{"concept_id": "C1150700", "aliases": ["formyltetrahydrofolic cyclodehydrase activity", "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)", "methenyl-THF synthetase activity", "5-formyltetrahydrofolate cyclo-ligase activity", "5-Formyltetrahydrofolate cyclodehydrase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate. [EC:6.3.3.2, RHEA:10488]", "canonical_name": "5,10-methenyltetrahydrofolate synthetase activity"}
{"concept_id": "C1150701", "aliases": ["dethiobiotin synthase activity", "DTB synthetase activity", "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate. [EC:6.3.3.3, RHEA:15805]", "canonical_name": "desthiobiotin synthase activity"}
{"concept_id": "C1150702", "aliases": ["phosphoribosyl-aminoimidazole synthetase activity", "AIR synthase activity", "phosphoribosylaminoimidazole synthetase activity", "AIRS activity", "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)", "phosphoribosylformylglycinamidine cyclo-ligase activity", "5'-aminoimidazole ribonucleotide synthetase activity", "AIR synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate. [EC:6.3.3.1, RHEA:23032]", "canonical_name": "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)"}
{"concept_id": "C1150703", "aliases": [], "types": ["T044"], "definition": "Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP. [PMID:16141198, PMID:17570395, RHEA:49288]", "canonical_name": "lipoate-protein ligase activity"}
{"concept_id": "C1150704", "aliases": ["lipoyl synthase activity", "LS", "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity", "lipoate synthase activity", "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity", "lipoic acid synthase"], "types": ["T044"], "definition": "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. [EC:2.8.1.8, PMID:18307109]", "canonical_name": "LipA"}
{"concept_id": "C1150705", "aliases": [], "types": ["T044"], "canonical_name": "lipoate-protein ligase A activity"}
{"concept_id": "C1150706", "aliases": [], "types": ["T044"], "canonical_name": "lipoate-protein ligase B activity"}
{"concept_id": "C1150709", "aliases": [], "types": ["T044"], "canonical_name": "other carbon-nitrogen ligase activity", "definition": "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized. [GOC:ai]"}
{"concept_id": "C1150710", "aliases": ["adenylosuccinate synthetase activity", "succinoadenylic kinosynthetase activity", "adenylosuccinate synthase activity", "IMP--aspartate ligase activity", "IMP:L-aspartate ligase (GDP-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. [EC:6.3.4.4, RHEA:15753]", "canonical_name": "succino-AMP synthetase activity"}
{"concept_id": "C1150711", "aliases": ["argininosuccinate synthase activity", "arginosuccinate synthetase activity", "L-citrulline:L-aspartate ligase (AMP-forming)", "citrulline--aspartate ligase activity", "argininosuccinic acid synthetase activity", "arginine succinate synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. [EC:6.3.4.5]", "canonical_name": "argininosuccinate synthetase activity"}
{"concept_id": "C1150712", "aliases": ["biotin carboxylase activity", "biotin carboxylase (component of acetyl CoA carboxylase) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. [EC:6.3.4.14]", "canonical_name": "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity"}
{"concept_id": "C1150713", "aliases": ["biotin-apoprotein ligase activity", "biotin--protein ligase activity"], "types": ["T044"], "canonical_name": "biotin-protein ligase activity", "definition": "Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein. [GOC:mah]"}
{"concept_id": "C1150715", "aliases": ["acetyl CoA holocarboxylase synthetase activity", "biotin-acetyl coenzyme A carboxylase synthetase activity", "acetyl-CoA carboxylase biotin holoenzyme synthetase activity", "acetyl coenzyme A holocarboxylase synthetase activity", "biotin-acetyl-CoA carboxylase synthetase", "biotin:apocarboxylase ligase activity", "biotin--[acetyl-CoA carboxylase] synthetase activity", "biotin-[acetyl-CoA-carboxylase] ligase activity", "HCS", "biotin holoenzyme synthetase activity", "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)). [EC:6.3.4.15]", "canonical_name": "biotin-acetyl-CoA-carboxylase ligase activity"}
{"concept_id": "C1150716", "aliases": ["biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity", "propionyl-CoA holocarboxylase synthetase activity", "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity", "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)", "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity", "biotin-methylcrotonoyl-CoA-carboxylase ligase activity", "biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity", "propionyl coenzyme A holocarboxylase synthetase activity", "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity", "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)", "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity", "holocarboxylase synthetase activity", "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity", "biotin-propionyl coenzyme A carboxylase synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)). [EC:6.3.4.11]", "canonical_name": "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity"}
{"concept_id": "C1150717", "aliases": ["biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity", "biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity", "biotin-transcarboxylase synthetase activity", "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)", "biotin-methylmalonyl-CoA-carboxytransferase ligase activity", "biotin-methylmalonyl-CoA-carboxyltransferase synthetase", "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity", "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity", "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity", "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity", "methylmalonyl coenzyme A holotranscarboxylase synthetase activity", "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity", "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase). [EC:6.3.4.9]", "canonical_name": "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity"}
{"concept_id": "C1150719", "aliases": ["UTP--ammonia ligase activity", "cytidine 5'-triphosphate synthetase activity", "CTP synthase activity", "cytidine triphosphate synthetase activity", "uridine triphosphate aminase activity", "UTP:ammonia ligase (ADP-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. [PMID:12354108, RHEA:26426]", "canonical_name": "CTP synthetase activity"}
{"concept_id": "C1150720", "aliases": ["tetrahydrofolate formylase activity", "formate:tetrahydrofolate ligase (ADP-forming)", "10-formyltetrahydrofolate synthetase activity", "formyltetrahydrofolate synthetase activity", "formate-tetrahydrofolate ligase activity", "10-formyl-THF synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. [EC:6.3.4.3]", "canonical_name": "tetrahydrofolic formylase activity"}
{"concept_id": "C1150721", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+). [RHEA:18301]", "canonical_name": "GMP synthase activity"}
{"concept_id": "C1150722", "aliases": ["glycineamide ribonucleotide synthetase activity", "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)", "phosphoribosylglycinamide synthetase activity", "glycinamide ribonucleotide synthetase activity", "GAR synthetase activity", "phosphoribosylglycineamide synthetase activity", "phosphoribosylamine-glycine ligase activity", "5'-phosphoribosylglycinamide synthetase activity", "GARS activity", "GAR"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. [EC:6.3.4.13, RHEA:17453]", "canonical_name": "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity"}
{"concept_id": "C1150724", "aliases": ["urea:carbon-dioxide ligase (ADP-forming)", "urease (ATP-hydrolyzing) activity", "UCA activity", "urea amidolyase activity", "urease (ATP-hydrolysing)", "ATP--urea amidolyase activity", "urea carboxylase (hydrolysing)", "urea carboxylase activity", "UALase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate. [EC:6.3.4.6, RHEA:20896]", "canonical_name": "urea carboxylase (hydrolyzing) activity"}
{"concept_id": "C1150725", "aliases": ["urease activase activity"], "types": ["T044"], "canonical_name": "urease activator activity", "definition": "Increases the activity of urease by promoting the incorporation of nickel into the active site. [GOC:mah, PMID:16244137]"}
{"concept_id": "C1150726", "aliases": [], "types": ["T044"], "canonical_name": "ligase activity, forming carbon-oxygen bonds", "definition": "Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.1.-.-, GOC:mah]"}
{"concept_id": "C1150729", "aliases": ["alanine transfer RNA synthetase activity", "AlaRS", "Ala-tRNA synthetase activity", "alanyl-transfer ribonucleic acid synthetase activity", "alanyl-transfer ribonucleate synthetase activity", "alanine-transfer RNA ligase activity", "alanine-tRNA ligase activity", "alanyl-transfer ribonucleate synthase activity", "alanine translase activity", "alanyl-transfer RNA synthetase activity", "alanine tRNA synthetase activity", "alanyl-tRNA synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). [EC:6.1.1.7]", "canonical_name": "L-alanine:tRNAAla ligase (AMP-forming)"}
{"concept_id": "C1150730", "aliases": [], "types": ["T044"], "canonical_name": "aminoacyl-tRNA synthetase auxiliary protein activity"}
{"concept_id": "C1150731", "aliases": ["arginyl-tRNA synthetase activity", "arginyl-transfer RNA synthetase activity", "arginine-tRNA ligase activity", "arginyl-transfer ribonucleate synthetase activity", "L-arginine:tRNAArg ligase (AMP-forming)", "arginine-tRNA synthetase activity", "arginine translase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). [EC:6.1.1.19]", "canonical_name": "arginyl transfer ribonucleic acid synthetase activity"}
{"concept_id": "C1150732", "aliases": ["asparagyl-transfer RNA synthetase activity", "asparaginyl transfer RNA synthetase activity", "L-asparagine:tRNAAsn ligase (AMP-forming)", "asparaginyl-transfer ribonucleate synthetase activity", "asparaginyl transfer ribonucleic acid synthetase activity", "asparaginyl-tRNA synthetase activity", "asparagine-tRNA ligase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+). [EC:6.1.1.22, RHEA:11180]", "canonical_name": "asparagine translase activity"}
{"concept_id": "C1150733", "aliases": ["L-aspartate:tRNAAsp ligase (AMP-forming)", "aspartyl-transfer ribonucleic acid synthetase activity", "aspartyl-tRNA synthetase activity", "aspartate-tRNA ligase activity", "aspartyl ribonucleic synthetase activity", "aspartic acid translase activity", "aspartyl-transfer RNA synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). [EC:6.1.1.12]", "canonical_name": "aspartyl ribonucleate synthetase activity"}
{"concept_id": "C1150734", "aliases": ["L-cysteine:tRNACys ligase (AMP-forming)", "cysteine translase activity", "cysteinyl-transferRNA synthetase activity", "cysteinyl-transfer ribonucleate synthetase activity", "cysteinyl-tRNA synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). [EC:6.1.1.16]", "canonical_name": "cysteine-tRNA ligase activity"}
{"concept_id": "C1150735", "aliases": ["glutamyl-transfer ribonucleic acid synthetase activity", "glutamate-tRNA synthetase activity", "L-glutamate:tRNAGlu ligase (AMP-forming) activity", "glutamyl-tRNA synthetase activity", "glutamyl-transfer RNA synthetase activity", "glutamyl-transfer ribonucleate synthetase activity", "glutamic acid translase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). [EC:6.1.1.17]", "canonical_name": "glutamate-tRNA ligase activity"}
{"concept_id": "C1150736", "aliases": ["glutamine-tRNA synthetase activity", "glutamine-tRNA ligase activity", "glutamine translase activity", "GlnRS", "glutaminyl-tRNA synthetase activity", "glutaminyl-transfer ribonucleate synthetase activity", "L-glutamine:tRNAGln ligase (AMP-forming)"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). [EC:6.1.1.18]", "canonical_name": "glutaminyl-transfer RNA synthetase activity"}
{"concept_id": "C1150737", "aliases": ["glycyl-transfer ribonucleate synthetase activity", "glycine:tRNAGly ligase (AMP-forming) activity", "glycyl-transfer RNA synthetase activity", "glycyl translase activity", "glycyl-transfer ribonucleic acid synthetase activity", "glycyl-tRNA synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). [EC:6.1.1.14]", "canonical_name": "glycine-tRNA ligase activity"}
{"concept_id": "C1150738", "aliases": ["histidine translase activity", "histidyl-transfer ribonucleate synthetase activity", "histidine-tRNA ligase activity", "L-histidine:tRNAHis ligase (AMP-forming)"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). [EC:6.1.1.21]", "canonical_name": "histidyl-tRNA synthetase activity"}
{"concept_id": "C1150739", "aliases": ["isoleucyl-transfer RNA synthetase activity", "isoleucine translase activity", "L-isoleucine:tRNAIle ligase (AMP-forming)", "isoleucine-tRNA synthetase activity", "isoleucine-transfer RNA ligase activity", "isoleucyl-tRNA synthetase activity", "isoleucine-tRNA ligase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). [EC:6.1.1.5, RHEA:11060]", "canonical_name": "isoleucyl-transfer ribonucleate synthetase activity"}
{"concept_id": "C1150740", "aliases": ["leucyl-transfer RNA synthetase activity", "leucine-tRNA synthetase activity", "leucine-tRNA ligase activity", "leucyl-tRNA synthetase activity", "leucyl-transfer ribonucleic acid synthetase activity", "leucyl-transfer ribonucleate synthetase activity", "leucine translase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu). [EC:6.1.1.4, RHEA:11688]", "canonical_name": "L-leucine:tRNALeu ligase (AMP-forming)"}
{"concept_id": "C1150741", "aliases": ["lysine translase activity", "L-lysine:tRNALys ligase (AMP-forming)", "lysine-tRNA synthetase activity", "lysyl-transfer RNA synthetase activity", "L-lysine-transfer RNA ligase activity", "lysine-tRNA ligase activity", "lysyl-tRNA synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). [EC:6.1.1.6]", "canonical_name": "lysyl-transfer ribonucleate synthetase activity"}
{"concept_id": "C1150742", "aliases": ["methionyl-transfer ribonucleate synthetase activity", "methionyl-transfer RNA synthetase activity", "methionyl-tRNA synthetase activity", "methionyl-transfer ribonucleic acid synthetase activity", "methionine translase activity", "methionine-tRNA ligase activity", "MetRS activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). [EC:6.1.1.10]", "canonical_name": "L-methionine:tRNAMet ligase (AMP-forming)"}
{"concept_id": "C1150743", "aliases": ["phenylalanyl-transfer RNA synthetase activity", "L-phenylalanyl-tRNA synthetase activity", "phenylalanine translase activity", "phenylalanine-tRNA ligase activity", "phenylalanine-tRNA synthetase activity", "phenylalanyl-tRNA ligase activity", "phenylalanyl-transfer RNA ligase activity", "phenylalanyl-tRNA synthetase activity", "phenylalanyl-transfer ribonucleate synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). [EC:6.1.1.20]", "canonical_name": "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity"}
{"concept_id": "C1150744", "aliases": ["L-proline:tRNAPro ligase (AMP-forming)", "prolyl-tRNA synthetase activity", "proline translase activity", "proline-tRNA ligase activity", "prolyl-s-RNA synthetase activity", "prolyl-transferRNA synthetase activity", "prolinyl-tRNA ligase activity", "prolyl-transfer ribonucleate synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). [EC:6.1.1.15]", "canonical_name": "prolyl-transfer ribonucleic acid synthetase activity"}
{"concept_id": "C1150745", "aliases": ["seryl-tRNA synthetase activity", "serine-tRNA ligase activity", "seryl-transfer ribonucleate synthetase activity", "SerRS activity", "L-serine:tRNASer ligase (AMP-forming)", "seryl-transfer RNA synthetase activity", "serine translase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). [EC:6.1.1.11]", "canonical_name": "seryl-transfer ribonucleic acid synthetase activity"}
{"concept_id": "C1150746", "aliases": ["threonyl-transfer RNA synthetase activity", "threonine translase activity", "threonyl ribonucleic synthetase activity", "threonine-transfer ribonucleate synthetase activity", "threonyl-transfer ribonucleic acid synthetase activity", "threonyl-transfer ribonucleate synthetase activity", "L-threonine:tRNAThr ligase (AMP-forming)", "threonine-tRNA ligase activity", "TRS"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). [EC:6.1.1.3]", "canonical_name": "threonyl-tRNA synthetase activity"}
{"concept_id": "C1150747", "aliases": ["tryptophanyl-tRNA synthetase activity", "L-tryptophan-tRNATrp ligase (AMP-forming)", "tryptophanyl ribonucleic synthetase activity", "tryptophanyl-tRNA synthase activity", "L-tryptophan:tRNATrp ligase (AMP-forming)", "TrpRS activity", "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity", "tryptophanyl-transfer ribonucleic synthetase activity", "tryptophanyl-transfer ribonucleic acid synthetase activity", "tryptophanyl-transfer ribonucleate synthetase activity", "tryptophan-tRNA ligase activity", "tryptophanyl-transfer RNA synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). [EC:6.1.1.2]", "canonical_name": "tryptophan translase activity"}
{"concept_id": "C1150748", "aliases": ["tyrosyl-transfer ribonucleic acid synthetase activity", "tyrosyl-transfer ribonucleate synthetase activity", "tyrosyl-tRNA ligase activity", "tyrosyl-tRNA synthetase activity", "tyrosine-tRNA ligase activity", "tyrosine tRNA synthetase activity", "L-tyrosine-tRNATyr ligase (AMP-forming)", "tyrosyl-transfer RNA synthetase activity", "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity", "tyrosine-transfer RNA ligase activity", "L-tyrosine:tRNATyr ligase (AMP-forming)", "tyrosine-transfer ribonucleate synthetase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). [EC:6.1.1.1, RHEA:10220]", "canonical_name": "tyrosine translase activity"}
{"concept_id": "C1150749", "aliases": ["valyl-transfer ribonucleic acid synthetase activity", "L-valine:tRNAVal ligase (AMP-forming)", "valyl-transfer ribonucleate synthetase activity", "valyl-transfer RNA synthetase activity", "valine translase activity", "valine transfer ribonucleate ligase activity", "valine-tRNA ligase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). [EC:6.1.1.9, RHEA:10704]", "canonical_name": "valyl-tRNA synthetase activity"}
{"concept_id": "C1150750", "aliases": ["ligase activity, forming carbon-sulphur bonds"], "types": ["T044"], "canonical_name": "ligase activity, forming carbon-sulfur bonds", "definition": "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.2.-.-, GOC:mah]"}
{"concept_id": "C1150751", "aliases": [], "types": ["T044"], "canonical_name": "acid-thiol ligase activity", "definition": "Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.2.1.-, GOC:mah]"}
{"concept_id": "C1150752", "aliases": ["6-carboxyhexanoyl-CoA synthetase activity", "pimeloyl-CoA synthetase activity", "6-carboxyhexanoate:CoA ligase (AMP-forming)", "pimelyl-CoA synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H(+) + pimelyl-CoA. [EC:6.2.1.14, RHEA:14781]", "canonical_name": "6-carboxyhexanoate-CoA ligase activity"}
{"concept_id": "C1150753", "aliases": [], "types": ["T044"], "canonical_name": "CoA-ligase activity", "definition": "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. [GOC:ai]"}
{"concept_id": "C1150754", "aliases": [], "types": ["T044"], "canonical_name": "2,4-dichlorobenzoate-CoA ligase activity", "definition": "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA. [UM-BBD_reactionID:r0137]"}
{"concept_id": "C1150755", "aliases": [], "types": ["T044"], "canonical_name": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity", "definition": "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA. [UM-BBD_reactionID:r0429]"}
{"concept_id": "C1150756", "aliases": ["3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity", "definition": "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. [UM-BBD_reactionID:r0737]"}
{"concept_id": "C1150757", "aliases": ["4-chlorobenzoate-CoA ligase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway. [EC:6.2.1.33]", "canonical_name": "4-chlorobenzoate:CoA ligase activity"}
{"concept_id": "C1150758", "aliases": ["hydroxycinnamoyl CoA synthetase activity", "4-coumarate:CoA ligase activity", "4CL", "p-hydroxycinnamic acid:CoA ligase activity", "4-coumaroyl-CoA synthetase activity", "caffeolyl coenzyme A synthetase activity", "4-coumaroyl-CoA synthase activity", "sinapoyl coenzyme A synthetase activity", "feruloyl CoA ligase activity", "4-coumarate:coenzyme A ligase activity", "hydroxycinnamate:CoA ligase activity", "p-coumaryl coenzyme A synthetase activity", "feruloyl coenzyme A synthetase activity", "p-coumaryl-CoA ligase activity", "4-coumarate-CoA ligase activity", "p-coumaryl-CoA synthetase activity", "4-coumaryl-CoA synthetase activity", "4-coumarate:CoA ligase (AMP-forming)", "p-hydroxycinnamoyl coenzyme A synthetase activity", "p-coumaroyl CoA ligase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA. [EC:6.2.1.12]", "canonical_name": "4-coumarate-CoA synthetase activity"}
{"concept_id": "C1150759", "aliases": ["4-hydroxybenzoate-coenzyme A ligase (AMP-forming)", "4-hydroxybenzoyl coenzyme A synthetase activity", "4-hydroxybenzoate:CoA ligase (AMP-forming)", "4-hydroxybenzoate-CoA ligase activity", "4-hydroxybenzoate-CoA synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA. [EC:6.2.1.27]", "canonical_name": "4-hydroxybenzoyl-CoA ligase activity"}
{"concept_id": "C1150760", "aliases": ["acetyl-CoA synthase activity", "acetyl-activating enzyme activity", "acetyl coenzyme A synthetase activity", "acetyl CoA synthase activity", "acetyl CoA ligase activity", "ACS", "acetate:CoA ligase (AMP-forming)", "short chain fatty acyl-CoA synthetase activity", "acetate to acetyl-CoA", "acetyl-coenzyme A synthase activity", "acyl-activating enzyme activity", "acetic thiokinase activity", "short-chain acyl-coenzyme A synthetase activity", "acetate-CoA ligase activity", "acetyl-CoA synthetase activity", "acetate thiokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. [EC:6.2.1.1]", "canonical_name": "acetyl activating enzyme"}
{"concept_id": "C1150762", "aliases": ["2-aminobenzoate-CoA ligase activity", "anthraniloyl coenzyme A synthetase activity", "anthranilate--CoA ligase activity", "anthranilate:CoA ligase (AMP-forming)", "2-aminobenzoate-coenzyme A ligase activity", "2-aminobenzoate coenzyme A ligase activity"], "types": ["T044"], "canonical_name": "anthranilate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA. [EC:6.2.1.32]"}
{"concept_id": "C1150763", "aliases": ["benzoyl CoA synthetase (AMP forming)", "benzoate-coenzyme A ligase activity", "benzoyl-coenzyme A synthetase activity", "benzoate-CoA ligase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate. [EC:6.2.1.25, RHEA:10132]", "canonical_name": "benzoate:CoA ligase (AMP-forming)"}
{"concept_id": "C1150764", "aliases": [], "types": ["T044"], "canonical_name": "benzoyl acetate-CoA ligase activity", "definition": "Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA. [UM-BBD_reactionID:r0242]"}
{"concept_id": "C1150765", "aliases": ["o-succinylbenzoate:CoA ligase (AMP-forming)", "o-succinylbenzoyl-coenzyme A synthetase activity", "2-succinylbenzoate:CoA ligase (AMP-forming)", "OSB-CoA synthetase activity", "o-succinylbenzoyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "o-succinylbenzoate-CoA ligase activity", "definition": "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate. [EC:6.2.1.26]"}
{"concept_id": "C1150766", "aliases": ["perillyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "perillyl-CoA synthetase activity", "definition": "OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA. [UM-BBD_reactionID:r0731]"}
{"concept_id": "C1150767", "aliases": [], "types": ["T044"], "canonical_name": "succinate-CoA ligase activity", "definition": "Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA. [GOC:ai]"}
{"concept_id": "C1150768", "aliases": ["succinate thiokinase activity", "succinyl-CoA synthetase activity", "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity", "succinate-CoA ligase (ADP-forming) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. [PMID:9874242, RHEA:17661]", "canonical_name": "succinyl-CoA synthetase (ADP-forming) activity"}
{"concept_id": "C1150769", "aliases": ["succinyl-CoA synthetase (GDP-forming) activity", "succinyl CoA synthetase activity", "succinate:CoA ligase (GDP-forming) activity", "succinate-CoA ligase (GDP-forming) activity", "succinyl coenzyme A synthetase (GDP-forming) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. [RHEA:22120]", "canonical_name": "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity"}
{"concept_id": "C1150772", "aliases": ["long-chain-fatty-acyl-CoA synthetase activity", "LCFA synthetase activity", "long-chain fatty acid-CoA ligase activity", "long-chain-fatty-acid-CoA ligase activity", "fatty acid thiokinase (long-chain) activity", "long-chain fatty acyl coenzyme A synthetase activity", "long-chain acyl-CoA synthetase activity", "lignoceroyl-CoA synthase activity", "acyl-CoA synthetase activity", "long-chain acyl CoA synthetase activity", "long-chain acyl-coenzyme A synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [RHEA:15421]", "canonical_name": "long chain fatty acyl-CoA synthetase activity"}
{"concept_id": "C1150773", "aliases": ["citrate lyase ligase activity", "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)", "citrate lyase synthetase activity", "acetate:HS-citrate lyase ligase activity", "citrate (pro-3S)-lyase ligase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form). [EC:6.2.1.22]", "canonical_name": "[citrate (pro-3S)-lyase] ligase activity"}
{"concept_id": "C1150774", "aliases": [], "types": ["T044"], "canonical_name": "ligase activity, forming phosphoric ester bonds", "definition": "Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.5.-.-, GOC:mah]"}
{"concept_id": "C1150775", "aliases": [], "types": ["T045"], "definition": "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. [ISBN:0716720094]", "canonical_name": "DNA ligase activity"}
{"concept_id": "C1150776", "aliases": ["poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)", "polydeoxyribonucleotide synthase (ATP) activity", "DNA ligase (ATP) activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). [EC:6.5.1.1]", "canonical_name": "polynucleotide ligase (ATP) activity"}
{"concept_id": "C1150777", "aliases": ["Polydeoxyribonucleotide synthase (NAD(+)) activity", "polynucleotide ligase (NAD+) activity", "polynucleotide ligase (NAD(+)) activity", "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)", "polynucleotide ligase (NAD)", "polydeoxyribonucleotide synthase (NAD)", "DNA ligase (NAD+) activity", "polynucleotide synthetase activity", "polynucleotide ligase (nicotinamide adenine dinucleotide)", "polynucleotide synthetase (nicotinamide adenine dinucleotide)", "DNA ligase (NAD)"], "types": ["T045"], "definition": "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). [EC:6.5.1.2]", "canonical_name": "polydeoxyribonucleotide synthase (NAD+) activity"}
{"concept_id": "C1150778", "aliases": [], "types": ["T045"], "definition": "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another. [GOC:mah]", "canonical_name": "RNA ligase activity"}
{"concept_id": "C1150779", "aliases": ["2'-5' RNA ligase activity"], "types": ["T044"], "canonical_name": "2'-5'-RNA ligase activity", "definition": "Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. [GOC:mah, PMID:8940112]"}
{"concept_id": "C1150780", "aliases": ["RNA ligase (ATP) activity", "polyribonucleotide synthase (ATP) activity", "polyribonucleotide ligase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). [EC:6.5.1.3]", "canonical_name": "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)"}
{"concept_id": "C1150781", "aliases": ["RNA cyclase activity", "RNA-3'-phosphate cyclase activity", "RNA 3'-terminal phosphate cyclase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. [EC:6.5.1.4]", "canonical_name": "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)"}
{"concept_id": "C1150782", "aliases": [], "types": ["T044"], "canonical_name": "O antigen ligase activity", "definition": "Catalysis of the reaction: Lipid A-core + colanic acid = MLPS. [MetaCyc:RXN0-5294]"}
{"concept_id": "C1150784", "aliases": [], "types": ["T044"], "definition": "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [ISBN:0198547684]", "canonical_name": "lyase activity"}
{"concept_id": "C1150785", "aliases": [], "types": ["T044"], "definition": "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:jl]", "canonical_name": "carbon-carbon lyase activity"}
{"concept_id": "C1150786", "aliases": [], "types": ["T044"], "definition": "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. [GOC:curators]", "canonical_name": "aldehyde-lyase activity"}
{"concept_id": "C1150787", "aliases": ["2-dehydro-3-deoxyglucarate aldolase activity", "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)", "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity", "alpha-keto-beta-deoxy-D-glucarate aldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde. [EC:4.1.2.20]", "canonical_name": "2-keto-3-deoxyglucarate aldolase activity"}
{"concept_id": "C1150788", "aliases": ["2-dehydro-3-deoxyphosphogalactonate aldolase activity", "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity", "(KDPGal)aldolase activity", "phospho-2-keto-3-deoxygalactonic aldolase activity", "phospho-2-keto-3-deoxygalactonate aldolase activity", "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity", "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)", "6-phospho-2-keto-3-deoxygalactonate aldolase activity", "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity", "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity", "2-keto-3-deoxy-6-phosphogalactonic aldolase activity"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity", "definition": "Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate. [EC:4.1.2.21, RHEA:24464]"}
{"concept_id": "C1150789", "aliases": ["2-keto-3-deoxy-6-phosphogluconate aldolase activity", "ODPG aldolase activity", "2-keto-3-deoxy-6-phosphogluconic aldolase activity", "2-keto-3-deoxygluconate-6-phosphate aldolase activity", "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)", "2-keto-3-deoxygluconate-6-P-aldolase activity", "2-oxo-3-deoxy-6-phosphogluconate aldolase activity", "KDPG-aldolase activity", "phospho-2-keto-3-deoxygluconate aldolase activity", "phospho-2-keto-3-deoxygluconic aldolase activity", "phospho-2-dehydro-3-deoxygluconate aldolase activity", "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity", "KDPG aldolase activity", "6-phospho-2-keto-3-deoxygluconate aldolase activity"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-phosphogluconate aldolase activity", "definition": "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. [EC:4.1.2.14]"}
{"concept_id": "C1150790", "aliases": ["DAH7-P synthase activity", "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity", "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)", "phospho-2-dehydro-3-deoxyheptonate aldolase activity", "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity", "KDPH synthase activity", "2-dehydro-3-deoxyphosphoheptonate aldolase activity", "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity", "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity", "3-deoxy-7-phosphoheptulonate synthase activity", "phospho-2-keto-3-deoxyheptonate aldolase activity", "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity", "DAHP synthase activity", "phospho-2-keto-3-deoxyheptonic aldolase activity", "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity", "2-dehydro-3-deoxy-phosphoheptonate aldolase activity", "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity", "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity", "phospho-2-oxo-3-deoxyheptonate aldolase activity", "DHAP synthase activity", "KDPH synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. [EC:2.5.1.54, RHEA:14717]", "canonical_name": "phospho-2-keto-3-deoxyheptanoate aldolase activity"}
{"concept_id": "C1150791", "aliases": ["KDO-8-P synthase activity", "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity", "3-deoxyoctulosonic 8-phosphate synthetase activity", "KDO-8-phosphate synthetase activity", "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)", "KDOP synthase activity", "phospho-2-keto-3-deoxyoctonate aldolase activity", "2-keto-3-deoxy-8-phosphooctonic synthetase activity", "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity", "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity", "3-deoxy-8-phosphooctulonate synthase activity", "2-dehydro-3-deoxy-phosphooctonate aldolase activity", "2-dehydro-3-deoxyphosphooctonate aldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate. [EC:2.5.1.55, RHEA:14053]", "canonical_name": "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity"}
{"concept_id": "C1150792", "aliases": ["deoxyribose-5-phosphate aldolase activity", "2-deoxyribose-5-phosphate aldolase activity", "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)", "phosphodeoxyriboaldolase activity", "deoxyribose-phosphate aldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. [EC:4.1.2.4, RHEA:12821]", "canonical_name": "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity"}
{"concept_id": "C1150793", "aliases": ["2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)", "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. [EC:4.1.2.25]", "canonical_name": "dihydroneopterin aldolase activity"}
{"concept_id": "C1150794", "aliases": ["fructose 1,6-diphosphate aldolase activity", "diphosphofructose aldolase activity", "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity", "fructose 1-phosphate aldolase activity", "fructose 1-monophosphate aldolase activity", "phosphofructoaldolase activity", "fructoaldolase activity", "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)", "ketose 1-phosphate aldolase activity", "SMALDO", "fructose diphosphate aldolase activity", "1,6-diphosphofructose aldolase activity", "zymohexase activity", "fructose-1-phosphate aldolase activity", "fructose-bisphosphate aldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate. [EC:4.1.2.13]", "canonical_name": "fructose-1,6-bisphosphate triosephosphate-lyase activity"}
{"concept_id": "C1150795", "aliases": ["L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)", "L-fuculose-1-phosphate lactaldehyde-lyase activity", "fuculose aldolase activity", "L-fuculose 1-phosphate aldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate. [EC:4.1.2.17, RHEA:12933]", "canonical_name": "L-fuculose-phosphate aldolase activity"}
{"concept_id": "C1150797", "aliases": ["rhamnulose-1-phosphate aldolase activity", "L-rhamnulose-1-phosphate lactaldehyde-lyase activity", "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)", "rhamnulose phosphate aldolase activity", "L-rhamnulose-phosphate aldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. [EC:4.1.2.19]", "canonical_name": "L-rhamnulose 1-phosphate aldolase activity"}
{"concept_id": "C1150798", "aliases": ["sphinganine-1-phosphate alkanal-lyase activity", "sphinganine-1-phosphate aldolase activity", "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)", "dihydrosphingosine 1-phosphate aldolase activity", "sphingosine-1-phosphate lyase activity", "sphingosine-1-phosphate aldolase activity", "sphinganine-1-phosphate lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. [EC:4.1.2.27]", "canonical_name": "sphinganine-1-phosphate palmitaldehyde-lyase activity"}
{"concept_id": "C1150799", "aliases": ["KbaY", "tagatose 1,6-diphosphate aldolase activity", "AgaY", "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)", "D-tagatose-1,6-bisphosphate triosephosphate lyase activity", "D-tagatose-1,6-bisphosphate aldolase activity", "tagatose-1,6-bisphosphate aldolase 1", "AgaZ"], "types": ["T044"], "definition": "Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate. [EC:4.1.2.40, RHEA:22948]", "canonical_name": "tagatose-bisphosphate aldolase activity"}
{"concept_id": "C1150800", "aliases": ["L-threonine acetaldehyde-lyase activity", "L-threonine aldolase activity", "threonine aldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-threonine = glycine + acetaldehyde. [EC:4.1.2.5]", "canonical_name": "L-threonine acetaldehyde-lyase (glycine-forming)"}
{"concept_id": "C1150801", "aliases": ["L-allo-threonine acetaldehyde-lyase activity", "LtaA"], "types": ["T044"], "canonical_name": "L-allo-threonine aldolase activity", "definition": "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde. [PMID:9228760, RHEA:26209]"}
{"concept_id": "C1150803", "aliases": ["2-oxo-4-hydroxyglutaric aldolase activity", "2-keto-4-hydroxyglutarate aldolase activity", "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)", "hydroxyketoglutarate aldolase activity", "DL-4-hydroxy-2-ketoglutarate aldolase activity", "2-keto-4-hydroxybutyrate aldolase activity", "4-hydroxy-2-ketoglutaric aldolase activity", "KHG-aldolase activity", "2-keto-4-hydroxyglutaric aldolase activity", "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity", "2-oxo-4-hydroxyglutarate aldolase activity", "4-hydroxy-2-ketoglutarate aldolase activity", "4-hydroxy-2-oxoglutarate aldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. [EC:4.1.3.16]", "canonical_name": "hydroxyketoglutaric aldolase activity"}
{"concept_id": "C1150805", "aliases": ["decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. [GOC:curators]", "canonical_name": "carboxy-lyase activity"}
{"concept_id": "C1150807", "aliases": [], "types": ["T044"], "canonical_name": "2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity", "definition": "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde. [PMID:8529896]"}
{"concept_id": "C1150808", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity", "definition": "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate. [UM-BBD_reactionID:r0621]"}
{"concept_id": "C1150809", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate. [UM-BBD_reactionID:r0398]", "canonical_name": "2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity"}
{"concept_id": "C1150810", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyisobutyrate decarboxylase activity", "definition": "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol. [UM-BBD_reactionID:r0617]"}
{"concept_id": "C1150811", "aliases": ["alpha-ketoglutaric decarboxylase activity", "pre-2-oxoglutarate decarboxylase activity", "alpha-ketoglutarate decarboxylase activity", "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)", "2-oxoglutarate carboxy-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + H(+) = CO(2) + succinate semialdehyde. [EC:4.1.1.71, RHEA:10524]", "canonical_name": "2-oxoglutarate decarboxylase activity"}
{"concept_id": "C1150812", "aliases": [], "types": ["T044"], "canonical_name": "3,5-dibromo-4-hydroxybenzoate decarboxylase activity", "definition": "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol. [UM-BBD_reactionID:r0546]"}
{"concept_id": "C1150813", "aliases": ["3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity", "3-octaprenyl-4-hydroxybenzoate decarboxylase activity", "PPHB decarboxylase activity", "polyprenyl p-hydroxybenzoate decarboxylase activity", "3-polyprenyl 4-hydroxybenzoate decarboxylase activity", "UbiX", "UbiD"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2. [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN]", "canonical_name": "3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity"}
{"concept_id": "C1150815", "aliases": ["4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)", "4,5-dihydroxyphthalate decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2. [EC:4.1.1.55]", "canonical_name": "4,5-dihydroxyphthalate carboxy-lyase activity"}
{"concept_id": "C1150816", "aliases": ["p-hydroxybenzoate decarboxylase activity", "4-hydroxybenzoate decarboxylase activity", "4-hydroxybenzoate carboxy-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxybenzoate + H(+) = CO(2) + phenol. [EC:4.1.1.61, RHEA:10876]", "canonical_name": "4-hydroxybenzoate carboxy-lyase (phenol-forming)"}
{"concept_id": "C1150817", "aliases": ["HpaG-2", "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity", "5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity", "HpaG2", "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity", "OPET decarboxylase activity", "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. [EC:4.1.1.68]", "canonical_name": "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)"}
{"concept_id": "C1150818", "aliases": ["S-adenosyl-L-methionine decarboxylase activity", "adenosylmethionine decarboxylase activity", "S-adenosyl-L-methionine carboxy-lyase activity", "S-adenosylmethionine decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2). [EC:4.1.1.50, RHEA:15981]", "canonical_name": "adenosyl methionine decarboxylase activity"}
{"concept_id": "C1150819", "aliases": ["L-arginine carboxy-lyase (agmatine-forming)", "arginine decarboxylase activity", "SpeA"], "types": ["T044"], "definition": "Catalysis of the reaction: L-arginine + H(+) = agmatine + CO(2). [EC:4.1.1.19, RHEA:17641]", "canonical_name": "L-arginine carboxy-lyase activity"}
{"concept_id": "C1150820", "aliases": ["L-DOPA decarboxylase activity", "DDC activity", "DOPA decarboxylase activity", "4-dihydroxyl-L-phenylalanine decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine. [GOC:bf, GOC:PARL, RHEA:12272]", "canonical_name": "L-dopa decarboxylase activity"}
{"concept_id": "C1150821", "aliases": ["L-aspartate alpha-decarboxylase activity", "L-aspartate 1-carboxy-lyase activity", "L-aspartate 1-carboxy-lyase (beta-alanine-forming)", "aspartate 1-decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-aspartate = beta-alanine + CO2. [EC:4.1.1.11]", "canonical_name": "aspartate alpha-decarboxylase activity"}
{"concept_id": "C1150822", "aliases": ["DDA decarboxylase activity"], "types": ["T044"], "canonical_name": "bis(4-chlorophenyl)acetate decarboxylase activity", "definition": "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM. [UM-BBD_reactionID:r0520]"}
{"concept_id": "C1150823", "aliases": ["DAP decarboxylase activity", "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)", "meso-diaminopimelate decarboxylase activity", "meso-2,6-diaminoheptanedioate carboxy-lyase activity", "DAP-decarboxylase activity", "diaminopimelate decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2). [EC:4.1.1.20, RHEA:15101]", "canonical_name": "diaminopimelic acid decarboxylase activity"}
{"concept_id": "C1150824", "aliases": ["mevalonate 5-diphosphate decarboxylase activity", "mevalonate-5-pyrophosphate decarboxylase activity", "pyrophosphomevalonate decarboxylase activity", "5-pyrophosphomevalonate decarboxylase activity", "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)", "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)", "mevalonate diphosphate decarboxylase activity", "diphosphomevalonate decarboxylase activity", "pyrophosphomevalonic acid decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate. [EC:4.1.1.33, RHEA:23732]", "canonical_name": "mevalonate pyrophosphate decarboxylase activity"}
{"concept_id": "C1150825", "aliases": ["gallate carboxy-lyase activity", "gallate carboxy-lyase (pyrogallol-forming)", "gallate decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: gallate + H(+) = CO(2) + pyrogallol. [EC:4.1.1.59, RHEA:12749]", "canonical_name": "gallic acid decarboxylase activity"}
{"concept_id": "C1150826", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide. [PMID:18374194]", "canonical_name": "gamma-glutamyl carboxylase activity"}
{"concept_id": "C1150827", "aliases": ["glutaconyl coenzyme A decarboxylase activity", "4-carboxybut-2-enoyl-CoA carboxy-lyase activity", "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)", "glutaconyl-CoA decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: trans-glutaconyl-CoA + H(+) = but-2-enoyl-CoA + CO(2). [PMID:11248185, RHEA:23972]", "canonical_name": "pent-2-enoyl-CoA carboxy-lyase activity"}
{"concept_id": "C1150828", "aliases": ["glutamate decarboxylase activity", "gamma-glutamate decarboxylase activity", "L-glutamate 1-carboxy-lyase activity", "L-glutamate alpha-decarboxylase activity", "L-aspartate-alpha-decarboxylase activity", "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)", "L-glutamic acid decarboxylase activity", "L-glutamic decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. [EC:4.1.1.15]", "canonical_name": "cysteic acid decarboxylase activity"}
{"concept_id": "C1150829", "aliases": ["L-histidine carboxy-lyase (histamine-forming)", "L-histidine carboxy-lyase activity", "histidine decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-histidine = histamine + CO2. [EC:4.1.1.22]", "canonical_name": "L-histidine decarboxylase activity"}
{"concept_id": "C1150830", "aliases": ["indole-3-glycerol-phosphate synthase activity", "indoleglycerol phosphate synthetase activity", "indoleglycerol phosphate synthase activity", "indole-3-glycerophosphate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. [EC:4.1.1.48]", "canonical_name": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)"}
{"concept_id": "C1150831", "aliases": ["lysine decarboxylase activity", "L-lysine carboxy-lyase (cadaverine-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2). [EC:4.1.1.18, RHEA:22352]", "canonical_name": "L-lysine carboxy-lyase activity"}
{"concept_id": "C1150832", "aliases": ["(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)", "methylmalonyl-coenzyme A decarboxylase activity", "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity", "(S)-methylmalonyl-CoA carboxy-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2. [EC:7.2.4.3]", "canonical_name": "methylmalonyl-CoA decarboxylase activity"}
{"concept_id": "C1150833", "aliases": ["SpeC", "ornithine decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine. [EC:4.1.1.17, RHEA:22964]", "canonical_name": "L-ornithine carboxy-lyase (putrescine-forming)"}
{"concept_id": "C1150834", "aliases": ["orotic decarboxylase activity", "orotodylate decarboxylase activity", "orotate decarboxylase activity", "uridine 5'-monophosphate synthase activity", "orotidylic acid decarboxylase activity", "orotidine-5'-phosphate decarboxylase activity", "orotidine monophosphate decarboxylase activity", "OMPdcase activity", "orotidine 5'-phosphate decarboxylase activity", "OMP-DC", "orotidine-5'-phosphate carboxy-lyase (UMP-forming)", "UMP synthase activity", "orotidine phosphate decarboxylase activity", "orotidylic decarboxylase activity", "OMP decarboxylase activity", "ODCase activity", "orotidine-5'-monophosphate decarboxylase activity", "orotate monophosphate decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP. [EC:4.1.1.23, RHEA:11596]", "canonical_name": "orotidine-5'-phosphate carboxy-lyase activity"}
{"concept_id": "C1150835", "aliases": ["oxalate carboxy-lyase activity", "oxalate carboxy-lyase (formate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + oxalate = CO(2) + formate. [EC:4.1.1.2, RHEA:16509]", "canonical_name": "oxalate decarboxylase activity"}
{"concept_id": "C1150836", "aliases": ["oxalate beta-decarboxylase activity", "oxaloacetate carboxy-lyase activity", "oxaloacetate decarboxylase activity", "oxaloacetate carboxy-lyase (pyruvate-forming)", "oxalacetic acid decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: oxaloacetate = pyruvate + CO2. [EC:1.1.1.38, EC:1.1.1.40, EC:4.1.1.112]", "canonical_name": "oxaloacetate beta-decarboxylase activity"}
{"concept_id": "C1150837", "aliases": ["oxalyl coenzyme A decarboxylase activity", "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)", "oxalyl-CoA decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA. [EC:4.1.1.8, RHEA:19333]", "canonical_name": "oxalyl-CoA carboxy-lyase activity"}
{"concept_id": "C1150838", "aliases": ["PS decarboxylase activity", "phosphatidylserine decarboxylase activity", "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine. [EC:4.1.1.65, RHEA:20828]", "canonical_name": "phosphatidyl-L-serine carboxy-lyase activity"}
{"concept_id": "C1150839", "aliases": ["4-phosphopantotheoylcysteine decarboxylase activity", "phosphopantothenoylcysteine decarboxylase activity", "PPC-decarboxylase activity", "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity", "4-phosphopantothenoyl-L-cysteine decarboxylase activity", "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate. [EC:4.1.1.36, RHEA:16793]", "canonical_name": "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity"}
{"concept_id": "C1150840", "aliases": ["5-amino-1-ribosylimidazole 5-phosphate carboxylase activity", "5-phosphoribosyl-5-aminoimidazole carboxylase activity", "AIR carboxylase activity", "ADE2", "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity", "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). [EC:4.1.1.21, RHEA:10792]", "canonical_name": "phosphoribosylaminoimidazole carboxylase activity"}
{"concept_id": "C1150841", "aliases": ["2-oxo-acid carboxy-lyase (aldehyde-forming)", "pyruvate decarboxylase activity", "pyruvic decarboxylase activity", "alpha-ketoacid carboxylase activity", "alpha-carboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2. [EC:4.1.1.1]", "canonical_name": "2-oxo-acid carboxy-lyase activity"}
{"concept_id": "C1150842", "aliases": ["ribulose diphosphate carboxylase activity", "ribulose diphosphate carboxylase/oxygenase activity", "ribulose 1,5-bisphosphate carboxylase/oxygenase activity", "D-ribulose 1,5-diphosphate carboxylase activity", "ribulose 1,5-diphosphate carboxylase/oxygenase activity", "ribulose bisphosphate carboxylase/oxygenase activity", "ribulose 1,5-diphosphate carboxylase activity", "ribulose 1,5-bisphosphate carboxylase activity", "ribulose-bisphosphate carboxylase activity", "D-ribulose-1,5-bisphosphate carboxylase activity", "RuBisCO activity", "diphosphoribulose carboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O. [RHEA:23124]", "canonical_name": "RuBP carboxylase activity"}
{"concept_id": "C1150843", "aliases": ["cysteic decarboxylase activity", "sulfoalanine decarboxylase activity", "cysteinesulfinic acid decarboxylase activity", "CADCase/CSADCase activity", "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)", "cysteinesulfinate decarboxylase activity", "CSAD", "3-sulfino-L-alanine carboxy-lyase activity", "cysteine-sulfinate decarboxylase activity", "L-cysteinesulfinic acid decarboxylase activity", "sulfinoalanine decarboxylase activity", "sulphinoalanine decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. [EC:4.1.1.29]", "canonical_name": "CSADCase activity"}
{"concept_id": "C1150844", "aliases": ["glyoxylic carbo-ligase activity", "glyoxylate carboxy-lyase (dimerizing)", "tartronic semialdehyde carboxylase activity", "tartronate semialdehyde carboxylase activity", "glyoxylate carbo-ligase activity", "glyoxalate carboligase activity", "tartronate-semialdehyde synthase activity", "glyoxylate carboligase activity", "hydroxymalonic semialdehyde carboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2). [EC:4.1.1.47, RHEA:10136]", "canonical_name": "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)"}
{"concept_id": "C1150845", "aliases": ["2'-carboxybenzalpyruvate aldolase activity", "4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity", "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate. [EC:4.1.2.34]", "canonical_name": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)"}
{"concept_id": "C1150846", "aliases": ["L-tyrosine decarboxylase activity", "L-tyrosine carboxy-lyase (tyramine-forming)", "L-tyrosine carboxy-lyase activity", "L-(-)-tyrosine apodecarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-tyrosine = tyramine + CO2. [EC:4.1.1.25]", "canonical_name": "tyrosine decarboxylase activity"}
{"concept_id": "C1150847", "aliases": ["uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)", "uroporphyrinogen III decarboxylase activity", "uroporphyrinogen-III carboxy-lyase activity", "porphyrinogen decarboxylase activity", "uroporphyrinogen decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. [EC:4.1.1.37]", "canonical_name": "porphyrinogen carboxy-lyase activity"}
{"concept_id": "C1150848", "aliases": [], "types": ["T044"], "canonical_name": "other carbon-carbon lyase activity", "definition": "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized. [GOC:ai]"}
{"concept_id": "C1150849", "aliases": ["1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)", "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity", "1-aminocyclopropane carboxylic acid deaminase activity", "ACC deaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanate + NH(4)(+). [EC:3.5.99.7, RHEA:16933]", "canonical_name": "1-aminocyclopropane-1-carboxylate deaminase activity"}
{"concept_id": "C1150850", "aliases": ["decarbonylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO. [GOC:kad, PMID:6593720, PMID:8718622]", "canonical_name": "aldehyde decarbonylase activity"}
{"concept_id": "C1150851", "aliases": ["benzylsuccinate fumarate-lyase (toluene-forming)", "benzylsuccinate fumarate-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate. [EC:4.1.99.11, RHEA:10416]", "canonical_name": "benzylsuccinate synthase activity"}
{"concept_id": "C1150852", "aliases": [], "types": ["T045"], "definition": "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. [GOC:mah, PMID:11124949]", "canonical_name": "DNA photolyase activity"}
{"concept_id": "C1150853", "aliases": [], "types": ["T045"], "canonical_name": "DNA (6-4) photolyase activity", "definition": "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA. [GOC:mah, PMID:11124949]"}
{"concept_id": "C1150854", "aliases": ["L-tryptophan indole-lyase (deaminating; pyruvate forming) activity", "L-tryptophanase activity", "L-tryptophan indole-lyase activity", "TNase activity", "tryptophanase activity", "tryptophan catabolism, using tryptophanase", "tryptophan catabolic process, using tryptophanase"], "types": ["T044"], "definition": "Catalysis of the reaction: L-tryptophan + H(2)O = indole + NH(4)(+) + pyruvate. [RHEA:19553]", "canonical_name": "L-tryptophan indole-lyase (deaminating) activity"}
{"concept_id": "C1150855", "aliases": ["oxo-acid lyase activity", "oxoacid lyase activity"], "types": ["T044"], "definition": "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. [EC:4.1.3.-, GOC:jl]", "canonical_name": "oxo-acid-lyase activity"}
{"concept_id": "C1150856", "aliases": ["1-deoxyxylulose-5-phosphate synthase activity", "DXP-synthase activity", "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)", "DOXP synthase activity", "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2). [EC:2.2.1.7, RHEA:12605]", "canonical_name": "1-deoxy-D-xylulose-5-phosphate synthase activity"}
{"concept_id": "C1150857", "aliases": ["alpha-hydroxyglutarate synthase activity", "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity", "2-hydroxyglutaric synthetase activity", "2-hydroxyglutarate synthase activity", "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)", "hydroxyglutarate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+). [RHEA:19185]", "canonical_name": "2-hydroxyglutaratic synthetase activity"}
{"concept_id": "C1150858", "aliases": ["2-isopropylmalate synthase activity", "alpha-isopropylmalate synthetase activity", "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity", "alpha-isopropylmalic synthetase activity", "isopropylmalate synthetase activity", "isopropylmalate synthase activity", "alpha-isopropylmalate synthase activity", "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+). [RHEA:21524]", "canonical_name": "alpha-IPM synthetase activity"}
{"concept_id": "C1150859", "aliases": ["YfbB", "MenH", "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity", "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity", "6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate. [EC:4.2.99.20, RHEA:25597]", "canonical_name": "SHCHC synthase activity"}
{"concept_id": "C1150860", "aliases": ["pyruvate:pyruvate acetaldehydetransferase (decarboxylating)", "acetohydroxy acid synthetase activity", "acetolactic synthetase activity", "acetolactate pyruvate-lyase (carboxylating) activity", "alpha-acetohydroxyacid synthase activity", "alpha-acetohydroxy acid synthetase activity", "acetohydroxyacid synthase activity", "alpha-acetolactate synthetase activity", "alpha-acetolactate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. [RHEA:25249]", "canonical_name": "acetolactate synthase activity"}
{"concept_id": "C1150861", "aliases": ["anthranilate synthetase activity", "chorismate pyruvate-lyase (amino-accepting) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. [EC:4.1.3.27]", "canonical_name": "anthranilate synthase activity"}
{"concept_id": "C1150862", "aliases": ["citrate-ATP lyase activity", "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity", "ATP-citric lyase activity", "adenosine triphosphate citrate lyase activity", "ATP citrate (pro-S)-lyase activity", "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)", "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity", "ATP-citrate (pro-S)-lyase activity", "ATP-citrate (pro-S-)-lyase activity"], "types": ["T044"], "canonical_name": "ATP citrate synthase activity", "definition": "Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA. [RHEA:21160]"}
{"concept_id": "C1150863", "aliases": ["chorismate pyruvate lyase activity", "UbiC", "chorismate lyase activity", "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity", "CPL", "4-hydroxybenzoate synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate. [EC:4.1.3.40, RHEA:16505]", "canonical_name": "CL"}
{"concept_id": "C1150864", "aliases": ["citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity", "citrate synthetase activity", "citrate (Si)-synthase activity", "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)", "citrogenase activity", "oxalacetic transacetase activity", "(R)-citric synthase activity", "citric synthase activity", "citrate oxaloacetate-lyase, CoA-acetylating activity", "citric-condensing enzyme activity", "citrate condensing enzyme activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. [EC:2.3.3.1]", "canonical_name": "oxaloacetate transacetase activity"}
{"concept_id": "C1150865", "aliases": ["citrate aldolase activity", "citric aldolase activity", "citratase activity", "citridesmolase activity", "citrate (pro-3S)-lyase activity", "citrate lyase", "citritase activity", "citrate oxaloacetate-lyase activity", "citrate lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: citrate = acetate + oxaloacetate. [RHEA:10760]", "canonical_name": "citrase activity"}
{"concept_id": "C1150866", "aliases": ["(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)", "citryl-CoA lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate. [EC:4.1.3.34]", "canonical_name": "(3S)-citryl-CoA oxaloacetate-lyase activity"}
{"concept_id": "C1150867", "aliases": ["homocitrate synthase activity", "homocitrate synthetase activity", "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)", "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity", "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. [RHEA:12929]", "canonical_name": "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)"}
{"concept_id": "C1150868", "aliases": ["3-hydroxy-3-methylglutarate-CoA lyase activity", "HMG-CoA lyase activity", "3-hydroxy-3-methylglutaryl coenzyme A lyase activity", "3-hydroxy-3-methylglutaryl-CoA lyase activity", "hydroxymethylglutaryl-CoA lyase activity", "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)", "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA. [EC:4.1.3.4, RHEA:24404]", "canonical_name": "hydroxymethylglutaryl coenzyme A lyase activity"}
{"concept_id": "C1150869", "aliases": ["3-hydroxy-3-methylglutaryl coenzyme A synthetase activity", "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity", "3-hydroxy-3-methylglutaryl coenzyme A synthase activity", "beta-hydroxy-beta-methylglutaryl-CoA synthase activity", "HMG-CoA synthase activity", "3-hydroxy-3-methylglutaryl CoA synthetase activity", "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)", "acetoacetyl coenzyme A transacetase activity", "hydroxymethylglutaryl-CoA synthase activity", "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity", "hydroxymethylglutaryl coenzyme A synthase activity", "3-hydroxy-3-methylglutaryl-CoA synthase activity", "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+). [RHEA:10188]", "canonical_name": "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)"}
{"concept_id": "C1150870", "aliases": ["isocitritase activity", "isocitratase activity", "isocitrate glyoxylate-lyase (succinate-forming)", "ICL activity", "threo-DS-isocitrate glyoxylate-lyase activity", "isocitrate lyase activity", "isocitrase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: isocitrate = glyoxylate + succinate. [EC:4.1.3.1, RHEA:13245]", "canonical_name": "isocitrate glyoxylate-lyase activity"}
{"concept_id": "C1150871", "aliases": ["glyoxylate transacetase activity", "L-malate glyoxylate-lyase (CoA-acetylating) activity", "malate synthase activity", "glyoxylate transacetylase activity", "malate synthetase activity", "glyoxylic transacetase activity", "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+). [RHEA:18181]", "canonical_name": "malic synthetase activity"}
{"concept_id": "C1150872", "aliases": ["(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)", "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity", "MICL", "methylisocitrate lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. [EC:4.1.3.30, RHEA:16809]", "canonical_name": "2-methylisocitrate lyase activity"}
{"concept_id": "C1150873", "aliases": ["N-acetylneuraminic acid aldolase activity", "N-acetylneuraminate pyruvate-lyase activity", "acetylneuraminate pyruvate-lyase activity", "N-acetylneuraminic aldolase activity", "N-acetylneuraminic lyase activity", "N-acetylneuraminate aldolase activity", "NANA lyase activity", "neuraminic acid aldolase activity", "N-acetylneuraminate lyase activity", "N-acetylneuraminic acid lyase activity", "sialic acid aldolase activity", "acetylneuraminate lyase activity", "neuraminic aldolase activity", "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)", "NALase activity", "NPL", "neuraminate aldolase activity", "sialate lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. [EC:4.1.3.3, RHEA:23296]", "canonical_name": "sialic aldolase activity"}
{"concept_id": "C1150876", "aliases": [], "types": ["T044"], "definition": "Catalysis of the breakage of a bond between carbon and any halogen atom. [GOC:mah]", "canonical_name": "carbon-halide lyase activity"}
{"concept_id": "C1150877", "aliases": ["DDD dehydrochlorinase activity"], "types": ["T044"], "canonical_name": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity", "definition": "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. [UM-BBD_reactionID:r0513]"}
{"concept_id": "C1150878", "aliases": ["DDMS dehydrochlorinase activity"], "types": ["T044"], "canonical_name": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity", "definition": "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU. [UM-BBD_reactionID:r0515]"}
{"concept_id": "C1150879", "aliases": ["3-chloro-D-alanine dehydrochlorinase activity", "3-chloro-D-alanine chloride-lyase (deaminating)", "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3. [EC:4.5.1.2]", "canonical_name": "beta-chloro-D-alanine dehydrochlorinase activity"}
{"concept_id": "C1150880", "aliases": [], "types": ["T044"], "canonical_name": "5-chloro-1,2,4-trihydroxybenzene dechlorinase activity", "definition": "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone. [UM-BBD_reactionID:r0666]"}
{"concept_id": "C1150881", "aliases": ["DDTase activity", "DDT-as", "DDT dehydrochlorinase activity", "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity", "DDT-ase activity"], "types": ["T044"], "canonical_name": "DDT-dehydrochlorinase activity", "definition": "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+). [EC:4.5.1.1, RHEA:19217]"}
{"concept_id": "C1150882", "aliases": ["dichloromethane dehalogenase activity", "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+). [EC:4.5.1.3, RHEA:15397]", "canonical_name": "dichloromethane chloride-lyase (chloride-hydrolysing)"}
{"concept_id": "C1150883", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene. [UM-BBD_enzymeID:e0359]", "canonical_name": "gamma-hexachlorocyclohexane dehydrochlorinase activity"}
{"concept_id": "C1150884", "aliases": [], "types": ["T044"], "canonical_name": "halohydrin hydrogen-halide-lyase activity", "definition": "Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide. [PMID:8017917]"}
{"concept_id": "C1150885", "aliases": [], "types": ["T044"], "canonical_name": "halohydrin hydrogen-halide-lyase A activity", "definition": "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane. [UM-BBD_enzymeID:e0048]"}
{"concept_id": "C1150886", "aliases": [], "types": ["T044"], "canonical_name": "halohydrin hydrogen-halide-lyase B activity", "definition": "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane. [UM-BBD_enzymeID:e0050]"}
{"concept_id": "C1150887", "aliases": [], "types": ["T044"], "definition": "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). [EC:4.3.-.-]", "canonical_name": "carbon-nitrogen lyase activity"}
{"concept_id": "C1150888", "aliases": [], "types": ["T044"], "canonical_name": "amidine-lyase activity", "definition": "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. [EC:4.3.-.-, GOC:krc]"}
{"concept_id": "C1150889", "aliases": ["6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity", "adenylosuccinase activity", "adenylosuccinate lyase activity", "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity", "succino AMP-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. [EC:4.3.2.2]", "canonical_name": "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity"}
{"concept_id": "C1150890", "aliases": ["argininosuccinate lyase activity", "argininosuccinic acid lyase activity", "arginosuccinase activity", "omega-N-(L-arginino)succinate arginine-lyase activity", "arginine-succinate lyase activity", "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)", "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. [EC:4.3.2.1]", "canonical_name": "N-(L-argininosuccinate) arginine-lyase activity"}
{"concept_id": "C1150891", "aliases": ["HGAD", "peptidylamidoglycolate lyase activity", "alpha-hydroxyglycine amidating dealkylase activity", "PAL", "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity", "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)", "peptidylamidoglycolate peptidylamide-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate. [EC:4.3.2.5]", "canonical_name": "PGL"}
{"concept_id": "C1150892", "aliases": [], "types": ["T044"], "canonical_name": "amine-lyase activity", "definition": "Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate. [EC:4.3.-.-, GOC:krc]"}
{"concept_id": "C1150893", "aliases": ["(hydroxyamino)benzene mutase activity", "(hydroxyamino)benzene hydroxymutase activity", "HAB mutase activity", "hydroxylaminobenzene hydroxymutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol. [EC:5.4.4.1, UM-BBD_reactionID:r0304]", "canonical_name": "hydroxylaminobenzene mutase activity"}
{"concept_id": "C1150894", "aliases": ["3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)", "STR activity", "strictosidine synthetase activity", "strictosidine synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine. [EC:4.3.3.2, RHEA:15013]", "canonical_name": "3-alpha(S)-strictosidine tryptamine-lyase activity"}
{"concept_id": "C1150895", "aliases": [], "types": ["T044"], "canonical_name": "triethanolamine lyase activity", "definition": "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde. [UM-BBD_enzymeID:e0421]"}
{"concept_id": "C1150896", "aliases": [], "types": ["T044"], "definition": "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. [EC:4.3.-.-, GOC:krc]", "canonical_name": "ammonia-lyase activity"}
{"concept_id": "C1150897", "aliases": ["L-aspartate ammonia-lyase activity", "aspartate ammonia-lyase activity", "L-aspartase activity", "fumaric aminase activity", "L-aspartate ammonia-lyase (fumarate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: L-aspartate = fumarate + NH3. [EC:4.3.1.1]", "canonical_name": "aspartase activity"}
{"concept_id": "C1150898", "aliases": ["D-serine dehydratase (deaminating) activity", "D-serine dehydrase activity", "D-serine dehydratase activity", "D-serine deaminase activity", "D-hydroxyaminoacid dehydratase activity", "D-serine ammonia-lyase activity", "D-serine hydrolase activity", "D-serine ammonia-lyase (pyruvate-forming)", "D-hydroxy amino acid dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-serine = pyruvate + NH3. [EC:4.3.1.18]", "canonical_name": "D-serine hydro-lyase (deaminating) activity"}
{"concept_id": "C1150899", "aliases": ["diaminopropionatase activity", "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)", "2,3-diaminopropionate ammonia-lyase activity", "alpha,beta-diaminopropionate ammonia-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3. [EC:4.3.1.15]", "canonical_name": "diaminopropionate ammonia-lyase activity"}
{"concept_id": "C1150900", "aliases": ["ethanolamine ammonia-lyase activity", "ethanolamine deaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3. [EC:4.3.1.7]", "canonical_name": "ethanolamine ammonia-lyase (acetaldehyde-forming) activity"}
{"concept_id": "C1150901", "aliases": ["5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)", "formiminotetrahydrofolate cyclodeaminase activity", "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)"], "types": ["T044"], "canonical_name": "formimidoyltetrahydrofolate cyclodeaminase activity", "definition": "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+). [EC:4.3.1.4, RHEA:22736]"}
{"concept_id": "C1150902", "aliases": ["L-histidine ammonia-lyase activity", "L-histidine ammonia-lyase (urocanate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: L-histidine = urocanate + NH3. [EC:4.3.1.3]", "canonical_name": "histidine ammonia-lyase activity"}
{"concept_id": "C1150903", "aliases": ["porphobilinogen deaminase activity", "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)", "uroporphyrinogen synthase activity", "porphobilinogen ammonia-lyase (polymerizing)", "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity", "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)", "pre-uroporphyrinogen synthase activity", "uroporphyrinogen synthetase activity", "HMB-synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). [EC:2.5.1.61, RHEA:13185]", "canonical_name": "hydroxymethylbilane synthase activity"}
{"concept_id": "C1150904", "aliases": ["L-serine ammonia-lyase (pyruvate-forming) activity", "L-serine hydro-lyase (deaminating) activity", "L-serine deaminase activity", "L-serine ammonia-lyase activity", "L-serine dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-serine = pyruvate + NH3. [EC:4.3.1.17]", "canonical_name": "serine deaminase activity"}
{"concept_id": "C1150905", "aliases": ["ornithine cyclase (deaminating) activity", "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)", "L-ornithine ammonia-lyase (cyclizing)", "OCD activity", "ornithine cyclodeaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+). [EC:4.3.1.12, RHEA:24368]", "canonical_name": "ornithine cyclase activity"}
{"concept_id": "C1150906", "aliases": ["PAL activity", "phenylalanine ammonia-lyase activity", "phenylalanine deaminase activity", "phenylalanine ammonium-lyase activity", "phe ammonia-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate. [RHEA:21384]", "canonical_name": "L-phenylalanine ammonia-lyase activity"}
{"concept_id": "C1150907", "aliases": [], "types": ["T044"], "canonical_name": "other carbon-nitrogen lyase activity", "definition": "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases. [GOC:krc]"}
{"concept_id": "C1150908", "aliases": ["cyanate lyase activity", "cyanate aminohydrolase activity", "cyanate hydrolase activity", "cyanate hydratase activity", "carbamate hydro-lyase activity", "cyanate C-N-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cyanate + H2O = carbamate. [EC:4.2.1.104, RHEA:11120]", "canonical_name": "cyanase activity"}
{"concept_id": "C1150909", "aliases": [], "types": ["T044"], "definition": "Catalysis of the breakage of a carbon-oxygen bond. [EC:4.2.-.-]", "canonical_name": "carbon-oxygen lyase activity"}
{"concept_id": "C1150910", "aliases": [], "types": ["T044"], "canonical_name": "carbon-oxygen lyase activity, acting on phosphates", "definition": "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. [EC:4.2.3.-]"}
{"concept_id": "C1150911", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate. [EC:4.2.3.4, RHEA:21968]", "canonical_name": "3-dehydroquinate synthase activity"}
{"concept_id": "C1150912", "aliases": ["2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)", "6-pyruvoyltetrahydropterin synthase activity", "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity", "PTPS activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate. [EC:4.2.3.12, RHEA:22048]", "canonical_name": "6-pyruvoyl tetrahydrobiopterin synthase activity"}
{"concept_id": "C1150913", "aliases": ["aristolochene synthase activity", "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)", "trans,trans-farnesyl diphosphate aristolochene-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate. [EC:4.2.3.9]", "canonical_name": "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)"}
{"concept_id": "C1150914", "aliases": ["5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)", "chorismate synthase activity", "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. [EC:4.2.3.5, RHEA:21020]", "canonical_name": "5-enolpyruvylshikimate-3-phosphate phospholyase activity"}
{"concept_id": "C1150915", "aliases": ["ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)", "ent-kaurene synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate. [EC:4.2.3.19, RHEA:22220]", "canonical_name": "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)"}
{"concept_id": "C1150916", "aliases": ["glycerone-phosphate phospho-lyase activity", "methylglyoxal synthetase activity", "methylglyoxal synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate. [EC:4.2.3.3, RHEA:17937]", "canonical_name": "glycerone-phosphate phospho-lyase (methylglyoxal-forming)"}
{"concept_id": "C1150917", "aliases": ["O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)", "threonine synthase activity", "O-phospho-L-homoserine phospho-lyase (adding water)"], "types": ["T044"], "definition": "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate. [EC:4.2.3.1]", "canonical_name": "threonine synthetase activity"}
{"concept_id": "C1150918", "aliases": ["trichodiene synthase activity", "trichodiene synthetase activity", "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene. [EC:4.2.3.6, RHEA:12052]", "canonical_name": "trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity"}
{"concept_id": "C1150919", "aliases": [], "types": ["T044"], "canonical_name": "carbon-oxygen lyase activity, acting on polysaccharides", "definition": "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide. [EC:4.2.-.-]"}
{"concept_id": "C1150920", "aliases": ["chondroitin lyase activity", "chondroitin AC lyase activity", "ChnAC", "chondroitin AC eliminase activity", "chondroitinase activity"], "types": ["T044"], "definition": "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. [EC:4.2.2.5]", "canonical_name": "chondroitin sulfate lyase activity"}
{"concept_id": "C1150921", "aliases": ["heparitin-sulfate lyase activity", "heparin-sulfate lyase activity"], "types": ["T044"], "definition": "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar. [EC:4.2.2.8]", "canonical_name": "heparin-sulphate lyase activity"}
{"concept_id": "C1150922", "aliases": ["hyaluronate lyase activity", "mucinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. [EC:4.2.2.1]", "canonical_name": "glucuronoglycosaminoglycan lyase activity"}
{"concept_id": "C1150923", "aliases": ["pectate transeliminase activity", "polygalacturonic acid trans-eliminase activity", "endopectin methyltranseliminase activity", "(1->4)-alpha-D-galacturonan lyase activity", "polygalacturonic acid lyase activity", "endo-alpha-1,4-polygalacturonic acid lyase activity", "pectic acid lyase activity", "PPase-N activity", "polygalacturonate lyase activity", "endogalacturonate transeliminase activity", "pectic acid transeliminase activity", "alpha-1,4-D-endopolygalacturonic acid lyase activity", "PGA lyase activity", "polygalacturonic transeliminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. [EC:4.2.2.2]", "canonical_name": "pectate lyase activity"}
{"concept_id": "C1150924", "aliases": ["alginase activity", "poly(beta-D-mannuronate) lyase activity", "alginate lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. [EC:4.2.2.3]", "canonical_name": "poly(beta-D-1,4-mannuronide) lyase activity"}
{"concept_id": "C1150925", "aliases": ["rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity"], "types": ["T044"], "definition": "Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue. [PMID:8587995, PMID:8720076]", "canonical_name": "rhamnogalacturonase B activity"}
{"concept_id": "C1150926", "aliases": [], "types": ["T044"], "canonical_name": "hydro-lyase activity", "definition": "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. [EC:4.2.1.-]"}
{"concept_id": "C1150927", "aliases": ["(3R)-hydroxymyristoyl-ACP dehydratase activity", "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity"], "types": ["T044"], "canonical_name": "(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity", "definition": "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O. [EC:4.2.1.59, GOC:ai, PMID:12368867, RHEA:41892]"}
{"concept_id": "C1150928", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyisobutyrate dehydratase activity", "definition": "Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate. [UM-BBD_reactionID:r0618]"}
{"concept_id": "C1150929", "aliases": ["2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity", "HpaH", "2-oxo-hepta-3-ene-1,7-dioate hydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate. [UM-BBD_reactionID:r0369]", "canonical_name": "2-oxo-hept-3-ene-1,7-dioate hydratase activity"}
{"concept_id": "C1150930", "aliases": ["2-keto-4-pentenoate (vinylpyruvate)hydratase activity", "OEH activity", "2-oxopent-4-enoate hydratase activity", "4-hydroxy-2-oxopentanoate hydro-lyase activity", "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O. [EC:4.2.1.80]", "canonical_name": "2-keto-4-pentenoate hydratase activity"}
{"concept_id": "C1150931", "aliases": ["3-dehydroquinate hydro-lyase activity", "5-dehydroquinate dehydratase activity", "dehydroquinase activity", "5-dehydroquinase activity", "3-dehydroquinate hydrolase activity", "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)", "3-dehydroquinase activity", "5-dehydroquinate hydro-lyase activity", "DHQase", "3-dehydroquinate dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O. [EC:4.2.1.10, RHEA:21096]", "canonical_name": "dehydroquinate dehydratase activity"}
{"concept_id": "C1150932", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. [EC:4.2.1.118, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN]", "canonical_name": "3-dehydroshikimate dehydratase activity"}
{"concept_id": "C1150933", "aliases": ["3-hydroxyacyl-[acyl-carrier protein] dehydratase activity", "3-hydroxyacyl-ACP dehydratase activity"], "types": ["T044"], "canonical_name": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity", "definition": "Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein]. [MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN]"}
{"concept_id": "C1150934", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxyacyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA). [UM-BBD_ruleID:bt0291]"}
{"concept_id": "C1150935", "aliases": ["(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)", "crotonase activity", "D-3-hydroxybutyryl-CoA dehydratase activity", "D-3-hydroxybutyryl coenzyme A dehydratase activity", "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O. [EC:4.2.1.55, RHEA:17849]", "canonical_name": "3-hydroxybutyryl-CoA dehydratase activity"}
{"concept_id": "C1150936", "aliases": ["3-hydroxydecanoyl-acyl carrier protein dehydrase activity", "beta-hydroxyacyl-ACP dehydrase activity", "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity", "3-hydroxydecanoyl-ACP dehydratase activity", "beta-hydroxydecanoyl thiol ester dehydrase activity", "beta-hydroxydecanoate dehydrase activity", "FabA", "beta-hydroxydecanoyl thioester dehydrase activity", "beta-hydroxyacyl-acyl carrier protein dehydratase activity", "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity", "HDDase activity", "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity", "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity", "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity", "3-hydroxydecanoyl-acyl carrier protein dehydratase activity"], "types": ["T044"], "canonical_name": "3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity", "definition": "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O. [EC:4.2.1.59, PMID:8910376, RHEA:41860]"}
{"concept_id": "C1150937", "aliases": ["beta-hydroxypalmitoyl thioester dehydratase activity", "beta-hydroxypalmityl-ACP dehydrase activity", "3-hydroxypalmitoyl-ACP dehydratase activity", "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity", "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity", "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)", "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity", "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity", "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity", "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity", "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"], "types": ["T044"], "canonical_name": "3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity", "definition": "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O. [PMID:8088535, RHEA:41908]"}
{"concept_id": "C1150938", "aliases": ["(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)", "alpha-IPM isomerase activity", "alpha-isopropylmalate isomerase activity", "isopropylmalate isomerase activity", "beta-isopropylmalate dehydratase activity", "3-isopropylmalate dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. [EC:4.2.1.33]", "canonical_name": "(2R,3S)-3-isopropylmalate hydro-lyase activity"}
{"concept_id": "C1150939", "aliases": [], "types": ["T044"], "canonical_name": "3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity", "definition": "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine. [MetaCyc:RXN-645, UM-BBD_reactionID:r0051]"}
{"concept_id": "C1150940", "aliases": ["4a-hydroxytetrahydrobiopterin dehydratase activity", "4-alpha-hydroxytetrahydrobiopterin dehydratase activity", "4-alpha-hydroxy-tetrahydropterin dehydratase activity", "pterin-4-alpha-carbinolamine dehydratase activity", "tetrahydrobiopterin dehydratase activity", "4a-hydroxytetrahydrobiopterin hydro-lyase activity", "pterin-4a-carbinolamine dehydratase activity", "pterin-4alpha-carbinolamine dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O. [EC:4.2.1.96, RHEA:11920]", "canonical_name": "4alpha-hydroxy-tetrahydropterin dehydratase activity"}
{"concept_id": "C1150941", "aliases": ["methylthioribulose-1-phosphate dehydratase activity", "1-PMT-ribulose dehydratase activity", "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity", "5-methylthioribulose-1-phosphate 4-dehydratase activity", "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]", "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]"], "types": ["T044"], "canonical_name": "methylthioribulose 1-phosphate dehydratase activity", "definition": "Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O. [EC:4.2.1.109, RHEA:15549]"}
{"concept_id": "C1150942", "aliases": [], "types": ["T044"], "canonical_name": "6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity", "definition": "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA. [UM-BBD_reactionID:r0204]"}
{"concept_id": "C1150943", "aliases": ["acetylene hydratase activity", "acetaldehyde hydro-lyase activity", "AHy"], "types": ["T044"], "definition": "Catalysis of the reaction: acetaldehyde = acetylene + H(2)O. [EC:4.2.1.112, RHEA:17885]", "canonical_name": "AH"}
{"concept_id": "C1150944", "aliases": ["aconitase activity", "aconitate hydratase activity", "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "citrate(isocitrate) hydro-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. [EC:4.2.1.3, GOC:pde, GOC:vw]", "canonical_name": "cis-aconitase activity"}
{"concept_id": "C1150945", "aliases": ["altronate dehydratase activity", "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. [EC:4.2.1.7, RHEA:15957]", "canonical_name": "D-altronate hydro-lyase activity"}
{"concept_id": "C1150946", "aliases": ["carbonic dehydratase activity", "carboxyanhydrase activity", "carbonate dehydratase activity", "carbonate anhydrase activity", "carbonate hydro-lyase (carbon-dioxide-forming)", "anhydrase activity", "carbonic acid anhydrase activity", "carbonate hydro-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H2CO3 = CO2 + H2O. [EC:4.2.1.1]", "canonical_name": "carbonic anhydrase activity"}
{"concept_id": "C1150948", "aliases": ["urea hydro-lyase activity", "cyanamide hydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: urea = cyanamide + H(2)O. [EC:4.2.1.69, RHEA:23056]", "canonical_name": "urea hydro-lyase (cyanamide-forming)"}
{"concept_id": "C1150949", "aliases": ["formamide dehydratase activity", "formamide hydro-lyase activity", "cyanide hydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide. [EC:4.2.1.66, RHEA:21720]", "canonical_name": "formamide hydro-lyase (cyanide-forming)"}
{"concept_id": "C1150950", "aliases": [], "types": ["T044"], "canonical_name": "cyclohex-1-ene-1-carboxyl-CoA hydratase activity", "definition": "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA. [MetaCyc:R266-RXN, UM-BBD_reactionID:r0191]"}
{"concept_id": "C1150951", "aliases": ["cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity", "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity", "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity", "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity", "dienoyl-CoA hydratase activity"], "types": ["T044"], "canonical_name": "cyclohexa-1,5-dienecarbonyl-CoA hydratase activity", "definition": "Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H(2)O = 6-hydroxycyclohex-1-enecarbonyl-CoA. [EC:4.2.1.100, RHEA:21856]"}
{"concept_id": "C1150952", "aliases": ["cystathionine beta-synthase activity", "methylcysteine synthase activity", "L-serine hydro-lyase (adding homocysteine)", "serine sulfhydrylase activity", "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "beta-thionase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. [EC:4.2.1.22]", "canonical_name": "serine sulfhydrase activity"}
{"concept_id": "C1150953", "aliases": ["L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)", "4-hydroxy-tetrahydrodipicolinate synthase activity", "dihydrodipicolinate synthase activity", "dihydrodipicolinate synthetase activity", "dihydrodipicolinic acid synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O. [PMID:8993314, RHEA:34171]", "canonical_name": "DHDPS activity"}
{"concept_id": "C1150954", "aliases": ["DHAD", "2,3-dihydroxy-acid hydro-lyase activity", "dihydroxy acid dehydrase activity", "alpha,beta-dihydroxyisovalerate dehydratase activity", "alpha,beta-dihydroxyacid dehydratase activity", "dihydroxy-acid dehydratase activity", "2,3-dihydroxyisovalerate dehydratase activity", "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. [EC:4.2.1.9]", "canonical_name": "acetohydroxyacid dehydratase activity"}
{"concept_id": "C1150955", "aliases": ["dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)", "dTDP-glucose 4,6-hydro-lyase activity", "dTDPglucose 4,6-dehydratase activity", "thymidine diphosphoglucose oxidoreductase activity", "dTDPglucose 4,6-hydro-lyase activity", "TDP-glucose oxidoreductase activity"], "types": ["T044"], "canonical_name": "dTDP-glucose 4,6-dehydratase activity", "definition": "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O. [EC:4.2.1.46, RHEA:17221]"}
{"concept_id": "C1150956", "aliases": [], "types": ["T044"], "canonical_name": "E-phenylitaconyl-CoA hydratase activity", "definition": "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA. [UM-BBD_reactionID:r0331]"}
{"concept_id": "C1150957", "aliases": ["short-chain enoyl-CoA hydratase activity", "enoyl coenzyme A hydrase (L)", "2-octenoyl coenzyme A hydrase activity", "beta-hydroxyacid dehydrase activity", "enoyl hydrase activity", "trans-2-enoyl-CoA hydratase activity", "unsaturated acyl-CoA hydratase activity", "(3S)-3-hydroxyacyl-CoA hydro-lyase activity", "crotonyl hydrase activity", "ECH", "acyl coenzyme A hydrase activity", "short chain enoyl coenzyme A hydratase activity", "enoyl-CoA hydratase activity", "enol-CoA hydratase activity", "beta-hydroxyacyl-CoA dehydrase activity", "2-enoyl-CoA hydratase activity", "enoyl coenzyme A hydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. [EC:4.2.1.17]", "canonical_name": "hydratase, enoyl coenzyme A"}
{"concept_id": "C1150958", "aliases": ["long-chain enoyl coenzyme A hydratase activity", "long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity"], "types": ["T044"], "canonical_name": "long-chain-enoyl-CoA hydratase activity", "definition": "Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms. [EC:4.2.1.74]"}
{"concept_id": "C1150960", "aliases": ["L-malate hydro-lyase activity", "fumarate hydratase activity", "(S)-malate hydro-lyase (fumarate-forming)", "fumarase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-malate = fumarate + H(2)O. [EC:4.2.1.2, RHEA:12460]", "canonical_name": "(S)-malate hydro-lyase activity"}
{"concept_id": "C1150961", "aliases": ["D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)", "galactarate dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O. [EC:4.2.1.42, RHEA:16005]", "canonical_name": "D-galactarate hydro-lyase activity"}
{"concept_id": "C1150962", "aliases": ["D-galactonate dehydratase activity", "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)", "D-galactonate dehydrase activity", "galactonate dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O. [EC:4.2.1.6, RHEA:18649]", "canonical_name": "D-galactonate hydro-lyase activity"}
{"concept_id": "C1150963", "aliases": ["GDP-D-mannose 4,6-dehydratase activity", "guanosine 5'-diphosphate-D-mannose oxidoreductase activity", "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)", "guanosine diphosphomannose oxidoreductase activity", "Gmd", "GDPmannose 4,6-dehydratase activity", "GDP-D-mannose dehydratase activity", "guanosine diphosphomannose 4,6-dehydratase activity", "GDP-mannose 4,6-dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O. [EC:4.2.1.47, RHEA:23820]", "canonical_name": "GDP-mannose 4,6-hydro-lyase activity"}
{"concept_id": "C1150964", "aliases": ["glucarate dehydratase activity", "D-glucarate dehydratase activity", "D-glucarate hydro-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O. [EC:4.2.1.40]", "canonical_name": "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)"}
{"concept_id": "C1150965", "aliases": ["glycerol dehydrase activity", "glycerol hydro-lyase activity", "glycerol dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. [EC:4.2.1.30, PMID:18307109]", "canonical_name": "glycerol hydro-lyase (3-hydroxypropanal-forming)"}
{"concept_id": "C1150966", "aliases": ["LysF", "homoaconitase activity", "cis-homoaconitase activity", "HACN activity", "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity", "homoaconitate hydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O. [EC:4.2.1.36, RHEA:15485]", "canonical_name": "Lys4"}
{"concept_id": "C1150967", "aliases": ["imidazoleglycerol-phosphate dehydratase activity", "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity", "imidazoleglycerol phosphate dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O. [EC:4.2.1.19, RHEA:11040]", "canonical_name": "IGP dehydratase activity"}
{"concept_id": "C1150968", "aliases": ["6-phosphogluconate dehydrase activity", "6-phosphogluconic dehydrase activity", "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)", "6-phospho-D-gluconate hydro-lyase activity", "gluconate-6-phosphate dehydratase activity", "6-phosphogluconate dehydratase activity", "gluconate 6-phosphate dehydratase activity"], "types": ["T044"], "canonical_name": "phosphogluconate dehydratase activity", "definition": "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O. [EC:4.2.1.12, RHEA:17277]"}
{"concept_id": "C1150969", "aliases": ["tartrate dehydratase activity", "L(+)-tartrate dehydratase activity", "L-tartrate dehydratase activity", "L-(+)-tartaric acid dehydratase activity", "(R,R)-tartrate hydro-lyase activity", "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate. [EC:4.2.1.32, RHEA:15413]", "canonical_name": "tartaric acid dehydrase activity"}
{"concept_id": "C1150970", "aliases": ["L-carnitine dehydratase activity", "carnitine dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-carnitine = crotono-betaine + H(2)O. [EC:4.2.1.89, RHEA:14577]", "canonical_name": "L-carnitine hydro-lyase activity"}
{"concept_id": "C1150971", "aliases": ["lactoyl-CoA hydro-lyase activity", "lactyl-coenzyme A dehydrase activity", "lactyl CoA dehydratase activity", "lactoyl-CoA dehydratase activity", "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)", "lactoyl coenzyme A dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O. [EC:4.2.1.54, RHEA:34691]", "canonical_name": "acrylyl coenzyme A hydratase activity"}
{"concept_id": "C1150972", "aliases": ["altronate hydrolase activity", "mannonic hydrolase activity", "mannonate dehydratase activity", "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)", "D-mannonate hydrolyase activity", "D-mannonate hydro-lyase activity", "mannonate hydrolyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. [EC:4.2.1.8, RHEA:20097]", "canonical_name": "altronic hydro-lyase activity"}
{"concept_id": "C1150973", "aliases": ["methylglutaconyl coenzyme A hydratase activity", "methylglutaconase activity", "methylglutaconyl-CoA hydratase activity", "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)", "3-methylglutaconyl CoA hydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O. [EC:4.2.1.18, RHEA:21536]", "canonical_name": "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity"}
{"concept_id": "C1150974", "aliases": ["aliphatic nitrile hydratase activity", "NHase activity", "3-cyanopyridine hydratase activity", "nitrile hydratase activity", "H-NHase activity", "aliphatic-amide hydro-lyase (nitrile-forming)", "L-NHase activity", "nitrile hydro-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O. [RHEA:12673]", "canonical_name": "acrylonitrile hydratase activity"}
{"concept_id": "C1150977", "aliases": ["OxdB", "phenylacetaldoxime dehydratase activity", "arylacetaldoxime dehydratase activity", "PAOx dehydratase activity", "(Z)-phenylacetaldehyde-oxime hydro-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (trans)-phenylacetaldoxime = H(2)O + phenylacetonitrile. [EC:4.99.1.7, RHEA:20069]", "canonical_name": "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity"}
{"concept_id": "C1150978", "aliases": ["2-phosphoglycerate dehydratase activity", "2-phospho-D-glycerate-hydrolase activity", "phosphoenolpyruvate hydratase activity", "2-phosphoglycerate enolase activity", "2-phosphoglyceric dehydratase activity", "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)", "enolase activity", "2-phospho-D-glycerate hydro-lyase activity", "gamma-enolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. [EC:4.2.1.11, ISBN:0198506732]", "canonical_name": "phosphopyruvate hydratase activity"}
{"concept_id": "C1150979", "aliases": ["delta-aminolevulinic acid dehydratase activity", "5-levulinic acid dehydratase activity", "aminolevulinic dehydratase activity", "delta-aminolevulinate dehydratase activity", "aminolevulinate dehydratase activity", "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)", "porphobilinogen synthase activity", "delta-aminolevulinic dehydratase activity", "delta-aminolevulinic acid dehydrase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. [EC:4.2.1.24, RHEA:24064]", "canonical_name": "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)"}
{"concept_id": "C1150980", "aliases": ["prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)", "prephenate hydro-lyase (decarboxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. [EC:4.2.1.51]", "canonical_name": "prephenate dehydratase activity"}
{"concept_id": "C1150981", "aliases": ["psiUMP synthetase activity", "pseudouridine-5'-phosphate glycosidase activity", "pseudouridine monophosphate synthetase activity", "5-ribosyluracil 5-phosphate synthetase activity", "pseudouridylate synthase activity", "pseudouridylic acid synthetase activity", "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)", "pseudouridylate synthetase activity", "uracil hydro-lyase (adding D-ribose 5-phosphate)"], "types": ["T044"], "definition": "Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate. [EC:4.2.1.70, RHEA:18337]", "canonical_name": "pseudouridine monophosphate synthase activity"}
{"concept_id": "C1150982", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol. [PMID:9857081]", "canonical_name": "retinol dehydratase activity"}
{"concept_id": "C1150983", "aliases": ["scytalone 7,8-hydro-lyase activity", "scytalone dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O. [EC:4.2.1.94, RHEA:24396]", "canonical_name": "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)"}
{"concept_id": "C1150984", "aliases": ["threonine dehydrase activity", "L-threonine hydro-lyase (deaminating) activity", "L-threonine ammonia-lyase (2-oxobutanoate-forming)", "threonine ammonia-lyase activity", "L-threonine dehydratase activity", "L-threonine ammonia-lyase activity", "threonine deaminase activity", "threonine dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. [EC:4.3.1.19]", "canonical_name": "L-threonine deaminase activity"}
{"concept_id": "C1150985", "aliases": [], "types": ["T044"], "canonical_name": "trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity", "definition": "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene. [UM-BBD_reactionID:r0164]"}
{"concept_id": "C1150986", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde). [UM-BBD_enzymeID:e0257]", "canonical_name": "trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity"}
{"concept_id": "C1150987", "aliases": ["tryptophan synthetase activity", "indoleglycerol phosphate aldolase activity", "L-serine hydro-lyase (adding indoleglycerol-phosphate)", "L-tryptophan synthetase activity", "tryptophan desmolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. [RHEA:10532]", "canonical_name": "tryptophan synthase activity"}
{"concept_id": "C1150988", "aliases": ["urocanase activity", "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity", "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)", "imidazolonepropionate hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O. [EC:4.2.1.49, RHEA:13101]", "canonical_name": "urocanate hydratase activity"}
{"concept_id": "C1150989", "aliases": ["uroporphyrinogen III cosynthase activity", "hydroxymethylbilane hydro-lyase (cyclizing) activity", "uroporphyrinogen-III cosynthase activity", "URO-synthase activity", "uroporphyrinogen isomerase activity", "porphobilinogenase activity", "uroporphyrinogen-III cosynthetase activity", "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)"], "types": ["T044"], "canonical_name": "uroporphyrinogen-III synthase activity", "definition": "Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III. [EC:4.2.1.75, RHEA:18965]"}
{"concept_id": "C1150990", "aliases": [], "types": ["T044"], "canonical_name": "other carbon-oxygen lyase activity", "definition": "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases. [GOC:krc]"}
{"concept_id": "C1150991", "aliases": ["O-acetyl-L-serine sulfhydrylase activity", "cysteine synthase activity", "O-acetylserine sulfhydrylase activity", "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity", "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity", "O-acetylserine (thiol)-lyase activity", "cysteine synthetase activity", "acetylserine sulfhydrylase activity", "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)", "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity", "OAS sulfhydrylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. [EC:2.5.1.47]", "canonical_name": "O-acetyl-L-serine sulfohydrolase activity"}
{"concept_id": "C1150992", "aliases": ["O-acetylhomoserine (thiol)-lyase activity", "L-methionine anabolism, direct, from O-acetyl-L-homoserine", "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity", "O-acetyl-L-homoserine sulfhydrolase activity", "L-methionine formation, direct, from O-acetyl-L-homoserine", "O-acetylhomoserine aminocarboxypropyltransferase activity", "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity", "O-acetylhomoserine sulfhydrolase activity", "methionine biosynthetic process, direct, from O-acetyl-L-homoserine", "OAH sulfhydrylase activity", "L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine"], "types": ["T044"], "definition": "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers. [EC:2.5.1.49]", "canonical_name": "L-methionine synthesis, direct, from O-acetyl-L-homoserine"}
{"concept_id": "C1150993", "aliases": ["O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity", "O-succinyl-L-homoserine succinate-lyase activity", "CTT gamma synthase activity", "O-succinylhomoserine synthetase activity", "O-succinyl-L-homoserine (thiol)-lyase activity", "cystathionine g-synthase activity", "cystathionine synthetase activity", "cystathionine synthase activity", "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity", "O-succinylhomoserine synthase activity", "cystathionine gamma synthase activity", "O-succinylhomoserine (thiol)-lyase activity"], "types": ["T044"], "canonical_name": "cystathionine gamma-synthase activity", "definition": "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate. [EC:2.5.1.48]"}
{"concept_id": "C1150995", "aliases": ["carbon-sulfur lyase activity"], "types": ["T044"], "definition": "Catalysis of the elimination of hydrogen sulfide or substituted H2S. [EC:4.4.-.-]", "canonical_name": "carbon-sulphur lyase activity"}
{"concept_id": "C1150996", "aliases": ["aminocyclopropanecarboxylate synthase activity", "S-adenosyl-L-methionine methylthioadenosine-lyase activity", "1-aminocyclopropane-1-carboxylate synthase activity", "1-aminocyclopropanecarboxylate synthase activity", "1-aminocyclopropane-1-carboxylic acid synthase activity", "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)", "1-aminocyclopropane-1-carboxylate synthetase activity", "aminocyclopropanecarboxylic acid synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+). [EC:4.4.1.14, RHEA:21744]", "canonical_name": "ACC synthase activity"}
{"concept_id": "C1150998", "aliases": ["cystathionine beta-lyase activity", "cystine lyase activity", "beta-cystathionase activity", "cystathionine L-homocysteine-lyase (deaminating)", "L-cystathionine L-homocysteine-lyase (deaminating)", "beta C-S lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. [EC:4.4.1.8]", "canonical_name": "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)"}
{"concept_id": "C1150999", "aliases": ["cysteine desulfurylase activity", "cysteine desulfurase activity", "NIFS", "SufS", "IscS"], "types": ["T044"], "definition": "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. [EC:2.8.1.7]", "canonical_name": "L-cysteine:enzyme cysteine sulfurtransferase activity"}
{"concept_id": "C1151000", "aliases": ["L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. [RHEA:14005]", "canonical_name": "cystathionine gamma-lyase activity"}
{"concept_id": "C1151001", "aliases": ["D-cysteine sulfide-lyase (deaminating; pyruvate-forming)", "D-cysteine sulfide-lyase (deaminating)", "D-cysteine lyase activity"], "types": ["T044"], "canonical_name": "D-cysteine desulfhydrase activity", "definition": "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate. [EC:4.4.1.15]"}
{"concept_id": "C1151002", "aliases": ["cysteine sulfinate desulfinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite. [RHEA:28278]", "canonical_name": "cysteine sulphinate desulphinase activity"}
{"concept_id": "C1151003", "aliases": ["holocytochrome-c apocytochrome-c-lyase activity", "cytochrome c heme-lyase activity", "holocytochrome-c apocytochrome-c-lyase (heme-forming)", "holocytochrome c synthetase activity"], "types": ["T044"], "canonical_name": "holocytochrome-c synthase activity", "definition": "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme. [EC:4.4.1.17]"}
{"concept_id": "C1151004", "aliases": ["(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity", "aldoketomutase activity", "ketone-aldehyde mutase activity", "methylglyoxalase activity", "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)", "glyoxalase I activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. [EC:4.4.1.5, RHEA:19069]", "canonical_name": "lactoylglutathione lyase activity"}
{"concept_id": "C1151005", "aliases": ["L-methionine gamma-lyase activity", "L-methionine methanethiol-lyase (deaminating)", "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)", "methioninase activity", "L-methioninase activity", "methionine dethiomethylase activity", "methionine lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate. [EC:4.4.1.11, RHEA:23800]", "canonical_name": "methionine gamma-lyase activity"}
{"concept_id": "C1151006", "aliases": ["L-selenocysteine selenide-lyase (L-alanine-forming)", "selenocysteine lyase activity", "selenocysteine beta-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor. [EC:4.4.1.16]", "canonical_name": "selenocysteine reductase activity"}
{"concept_id": "C1151007", "aliases": [], "types": ["T044"], "canonical_name": "other lyase activity", "definition": "OBSOLETE. A grouping term for lyases that cannot be more accurately categorized. [GOC:ai]"}
{"concept_id": "C1151008", "aliases": ["alkylmercury mercuric-lyase activity", "organomercurial lyase activity", "organomercury lyase activity", "alkylmercury lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an alkylmercury + H+ = an alkane + Hg2+. [RHEA:18777]", "canonical_name": "alkylmercury mercuric-lyase (alkane-forming)"}
{"concept_id": "C1151009", "aliases": [], "types": ["T044"], "canonical_name": "carbon phosphorus lyase activity", "definition": "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate). [PMID:3804975]"}
{"concept_id": "C1151011", "aliases": ["ferro-protoporphyrin chelatase activity", "protoheme ferro-lyase activity", "heme synthetase activity", "iron chelatase activity", "protoheme ferro-lyase (protoporphyrin-forming)", "ferrochelatase activity", "heme synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX. [RHEA:22584]", "canonical_name": "protoheme ferrolyase activity"}
{"concept_id": "C1151012", "aliases": ["Mg-protoporphyrin IX chelatase activity", "protoporphyrin IX Mg-chelatase activity", "Mg-protoporphyrin IX magnesium-lyase activity", "magnesium-protoporphyrin IX chelatase activity", "protoporphyrin IX magnesium-chelatase activity", "magnesium-protoporphyrin chelatase activity", "Mg-chelatase activity", "Mg-protoporphyrin IX magnesio-lyase activity", "magnesium-chelatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate. [EC:6.6.1.1, RHEA:13961]", "canonical_name": "magnesium chelatase activity"}
{"concept_id": "C1151013", "aliases": [], "types": ["T044"], "definition": "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:jl]", "canonical_name": "phosphorus-oxygen lyase activity"}
{"concept_id": "C1151015", "aliases": ["adenylyl cyclase activity", "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity", "adenylate cyclase activity", "adenylylcyclase activity", "ATP diphosphate-lyase (cyclizing) activity", "3',5'-cyclic AMP synthetase activity", "adenyl cyclase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. [EC:4.6.1.1]", "canonical_name": "ATP pyrophosphate-lyase activity"}
{"concept_id": "C1151016", "aliases": ["calcium- and calmodulin-responsive adenylyl cyclase activity", "calcium/calmodulin-responsive adenylate cyclase activity"], "types": ["T044"], "canonical_name": "calcium- and calmodulin-responsive adenylate cyclase activity", "definition": "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin. [EC:4.6.1.1, GOC:mah]"}
{"concept_id": "C1151017", "aliases": ["guanylyl cyclase activity", "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity", "guanylate cyclase activity", "guanyl cyclase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. [EC:4.6.1.2]", "canonical_name": "GTP diphosphate-lyase (cyclizing) activity"}
{"concept_id": "C1151018", "aliases": [], "types": ["T044"], "canonical_name": "receptor guanylate cyclase activity", "definition": "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. [EC:4.6.1.2]"}
{"concept_id": "C1151019", "aliases": [], "types": ["T044"], "canonical_name": "natriuretic peptide receptor activity", "definition": "Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity. [GOC:mah, GOC:signaling]"}
{"concept_id": "C1151021", "aliases": ["Mo-molybdopterin cofactor sulphurase activity", "molybdopterin cofactor sulfurase activity", "molybdopterin synthase sulfurylase activity"], "types": ["T044"], "canonical_name": "Mo-molybdopterin cofactor sulfurase activity", "definition": "Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase. [GOC:mah, PMID:11549764]"}
{"concept_id": "C1151022", "aliases": [], "types": ["T044"], "definition": "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis. [PMID:18154309, PMID:8514783]", "canonical_name": "molybdopterin synthase activity"}
{"concept_id": "C1151023", "aliases": [], "types": ["T044"], "canonical_name": "N-acetyl-anhydromuramoyl-L-alanine amidase activity", "definition": "Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala. [MetaCyc:RXN0-5225]"}
{"concept_id": "C1151025", "aliases": ["N-acylmannosamine-6-P epimerase activity"], "types": ["T044"], "canonical_name": "N-acylmannosamine-6-phosphate 2-epimerase activity", "definition": "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate. [MetaCyc:NANE-RXN]"}
{"concept_id": "C1151026", "aliases": [], "types": ["T044"], "canonical_name": "N-ethylammeline chlorohydrolase activity", "definition": "Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+. [MetaCyc:R465-RXN]"}
{"concept_id": "C1151027", "aliases": ["O-antigen polymerase activity"], "types": ["T044"], "canonical_name": "O antigen polymerase activity", "definition": "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide. [GOC:jl, PMID:12045108]"}
{"concept_id": "C1151028", "aliases": ["oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]", "canonical_name": "redox activity"}
{"concept_id": "C1151030", "aliases": [], "types": ["T044"], "canonical_name": "2-octaprenylphenol hydroxylase activity", "definition": "Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O. [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN]"}
{"concept_id": "C1151031", "aliases": [], "types": ["T044"], "canonical_name": "2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity"}
{"concept_id": "C1151033", "aliases": ["3-KSR activity", "3-keto-steroid reductase activity"], "types": ["T044"], "canonical_name": "3-keto sterol reductase activity", "definition": "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+). [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880]"}
{"concept_id": "C1151034", "aliases": ["aldo-keto reductase (NADP) activity", "NADPH-dependent aldo-keto reductase activity", "aldo-keto reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. [GOC:ai]", "canonical_name": "aldo-keto reductase (NADP+) activity"}
{"concept_id": "C1151036", "aliases": [], "types": ["T044"], "definition": "Catalysis of the interconversion of arsenate and arsenite. [GOC:mah]", "canonical_name": "arsenate reductase activity"}
{"concept_id": "C1151037", "aliases": ["arsenate reductase (glutaredoxin) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. [EC:1.20.4.1, GOC:kd, PMID:10593884]", "canonical_name": "glutharedoxin:arsenate oxidoreductase activity"}
{"concept_id": "C1151038", "aliases": [], "types": ["T044"], "canonical_name": "arsenate reductase (thioredoxin) activity", "definition": "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin. [MetaCyc:RXN-10737]"}
{"concept_id": "C1151039", "aliases": [], "types": ["T044"], "canonical_name": "beta-carotene hydroxylase activity"}
{"concept_id": "C1151040", "aliases": ["C-14 sterol reductase activity", "sterol C14-reductase activity", "delta14-sterol reductase activity", "sterol C-14 reductase activity", "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN]", "canonical_name": "D14-sterol reductase activity"}
{"concept_id": "C1151041", "aliases": ["3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity", "definition": "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H. [EC:1.1.1.170, PMID:9811880]"}
{"concept_id": "C1151043", "aliases": ["chlorite dismutase activity", "chlorite O2-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: chloride + O(2) = chlorite. [EC:1.13.11.49, RHEA:21404]", "canonical_name": "chloride:oxygen oxidoreductase activity"}
{"concept_id": "C1151044", "aliases": ["penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)", "DAOCS activity", "expandase activity", "deacetoxycephalosporin-C synthase activity", "DAOC synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate. [EC:1.14.20.1, RHEA:20748]", "canonical_name": "deacetoxycephalosporin C synthetase activity"}
{"concept_id": "C1151045", "aliases": ["NQO2", "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity", "ribosyldihydronicotinamide dehydrogenase (quinone) activity", "NQO(2) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone. [RHEA:12364]", "canonical_name": "dihydronicotinamide riboside quinone reductase activity"}
{"concept_id": "C1151046", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide. [GOC:mah, PMID:1745247, PMID:6815189]", "canonical_name": "dihydropterin oxidase activity"}
{"concept_id": "C1151047", "aliases": ["disulphide oxidoreductase activity"], "types": ["T044"], "canonical_name": "disulfide oxidoreductase activity", "definition": "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. [GOC:curators]"}
{"concept_id": "C1151049", "aliases": ["glutathione disulphide oxidoreductase activity"], "types": ["T044"], "canonical_name": "glutathione disulfide oxidoreductase activity", "definition": "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. [GOC:mah]"}
{"concept_id": "C1151053", "aliases": ["DOPA dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid. [PMID:11711071]", "canonical_name": "dihydroxyphenylalanine dioxygenase activity"}
{"concept_id": "C1151054", "aliases": [], "types": ["T044"], "definition": "Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group. [PMID:9492312]", "canonical_name": "geranylgeranyl reductase activity"}
{"concept_id": "C1151057", "aliases": ["cytochrome c oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. [RHEA:11436]", "canonical_name": "cytochrome-c oxidase activity"}
{"concept_id": "C1151063", "aliases": ["cytochrome bo(3) oxidase", "cytochrome bo3 ubiquinol oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]. [RHEA:30251]", "canonical_name": "cytochrome bo oxidase"}
{"concept_id": "C1151064", "aliases": ["(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)"], "types": ["T044"], "canonical_name": "hydroxymethylbutenyl pyrophosphate reductase activity", "definition": "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate. [GOC:js, PMID:11818558]"}
{"concept_id": "C1151065", "aliases": [], "types": ["T044"], "canonical_name": "leucoanthocyanidin hydroxylase"}
{"concept_id": "C1151067", "aliases": [], "types": ["T044"], "definition": "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732]", "canonical_name": "monooxygenase activity"}
{"concept_id": "C1151068", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxy-2-naphthoate hydroxylase activity", "definition": "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene. [UM-BBD_reactionID:r0491]"}
{"concept_id": "C1151069", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate. [UM-BBD_reactionID:r0736]", "canonical_name": "1-hydroxy-2-oxolimonene 1,2-monooxygenase activity"}
{"concept_id": "C1151070", "aliases": ["2,4-dichlorophenol hydroxylase activity", "2,4-dichlorophenol 6-monooxygenase activity", "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O. [EC:1.14.13.20]", "canonical_name": "2,4-dichlorophenol monooxygenase activity"}
{"concept_id": "C1151071", "aliases": ["2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)", "2,6-dihydroxypyridine oxidase activity"], "types": ["T044"], "canonical_name": "2,6-dihydroxypyridine 3-monooxygenase activity", "definition": "Catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+). [EC:1.14.13.10, RHEA:16917]"}
{"concept_id": "C1151072", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-phenylacetate hydroxylase activity", "definition": "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate. [UM-BBD_reactionID:r0252]"}
{"concept_id": "C1151073", "aliases": [], "types": ["T044"], "canonical_name": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity", "definition": "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA. [UM-BBD_reactionID:r0430]"}
{"concept_id": "C1151074", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol. [UM-BBD_reactionID:r0081]", "canonical_name": "3,5-xylenol methylhydroxylase activity"}
{"concept_id": "C1151075", "aliases": ["3-hydroxybenzoate 4-monooxygenase activity", "3-hydroxybenzoate 4-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+). [EC:1.14.13.23, RHEA:11480]", "canonical_name": "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)"}
{"concept_id": "C1151076", "aliases": ["3-hydroxybenzoic acid-6-hydroxylase activity", "m-hydroxybenzoate 6-hydroxylase activity", "3-hydroxybenzoate 6-monooxygenase activity", "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADH + O(2) = 2,5-dihydroxybenzoate + H(2)O + NAD(+). [EC:1.14.13.24, RHEA:22692]", "canonical_name": "3-hydroxybenzoate 6-hydroxylase activity"}
{"concept_id": "C1151077", "aliases": [], "types": ["T044"], "canonical_name": "3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "definition": "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. [EC:1.14.13.-]"}
{"concept_id": "C1151078", "aliases": ["4-aminobenzoate monooxygenase activity", "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)", "4-aminobenzoate hydroxylase activity", "4-aminobenzoate 1-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2. [EC:1.14.13.27]", "canonical_name": "4-aminobenzoate dehydrogenase activity"}
{"concept_id": "C1151079", "aliases": ["4-hydroxybenzoate 1-monooxygenase activity", "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2. [EC:1.14.13.64]", "canonical_name": "4-hydroxybenzoate 1-hydroxylase activity"}
{"concept_id": "C1151080", "aliases": ["para-hydroxybenzoate hydroxylase activity", "p-hydroxybenzoate hydroxylase activity", "p-hydroxybenzoic hydroxylase activity", "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)", "4-hydroxybenzoate 3-monooxygenase activity", "p-hydroxybenzoic acid hydroxylase activity", "p-hydroxybenzoate hydrolyase activity", "4-hydroxybenzoate monooxygenase activity", "p-hydroxybenzoate-3-hydroxylase activity", "4-hydroxybenzoate 3-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O. [EC:1.14.13.2]", "canonical_name": "p-hydroxybenzoic acid hydrolase activity"}
{"concept_id": "C1151081", "aliases": ["4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))", "4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity", "4-hydroxybenzoate-3-hydroxylase activity", "4-hydroxybenzoate 3-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O. [EC:1.14.13.33]", "canonical_name": "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)"}
{"concept_id": "C1151082", "aliases": ["4-hydroxyphenylacetate 1-hydroxylase activity", "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)", "4-hydroxyphenylacetate 1-monooxygenase activity", "4-HPA 1-hydroxylase activity", "4-hydroxyphenylacetic 1-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O. [EC:1.14.13.18]", "canonical_name": "4-hydroxyphenyl-acetate 1-hydroxylase activity"}
{"concept_id": "C1151084", "aliases": [], "types": ["T044"], "canonical_name": "4-nitrophenol 4-monooxygenase activity", "definition": "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone. [RHEA:34327]"}
{"concept_id": "C1151085", "aliases": [], "types": ["T044"], "canonical_name": "6-hydroxy pseudo-oxynicotine monooxygenase activity", "definition": "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine. [UM-BBD_reactionID:r0480]"}
{"concept_id": "C1151086", "aliases": [], "types": ["T044"], "canonical_name": "6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "definition": "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. [UM-BBD_reactionID:r0048]"}
{"concept_id": "C1151087", "aliases": ["alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity", "fatty acid (omega-1)-hydroxylase activity", "1-hydroxylase activity", "alkane 1-monooxygenase activity", "alkane monooxygenase activity", "alkane 1-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. [EC:1.14.15.3]", "canonical_name": "alkane hydroxylase activity"}
{"concept_id": "C1151088", "aliases": ["alkene monooxygenase activity", "alkene,NADH:oxygen oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O. [EC:1.14.13.69]", "canonical_name": "alkene epoxygenase activity"}
{"concept_id": "C1151089", "aliases": [], "types": ["T044"], "canonical_name": "alpha-pinene monooxygenase [NADH] activity", "definition": "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide. [UM-BBD_reactionID:r0742]"}
{"concept_id": "C1151090", "aliases": ["anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)", "anthranilate hydroxylase (deaminating) activity", "anthranilate 2,3-dioxygenase (deaminating)", "anthranilate 3-monooxygenase (deaminating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: anthranilate + 2 H(+) + NADPH + O(2) = 2,3-dihydroxybenzoate + NADP(+) + NH(4)(+). [EC:1.14.13.35, RHEA:21236]", "canonical_name": "anthranilate 2,3-hydroxylase (deaminating) activity"}
{"concept_id": "C1151091", "aliases": ["2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)", "2-aminobenzoyl-CoA monooxygenase/reductase activity", "anthraniloyl-CoA monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+. [EC:1.14.13.40]", "canonical_name": "anthraniloyl coenzyme A reductase activity"}
{"concept_id": "C1151092", "aliases": [], "types": ["T044"], "canonical_name": "atrazine monooxygenase activity"}
{"concept_id": "C1151093", "aliases": ["benzoic acid 4-hydroxylase activity", "benzoate-para-hydroxylase activity", "4-hydroxybenzoic hydroxylase activity", "benzoate 4-hydroxylase activity", "benzoate-p-hydroxylase activity", "benzoic 4-hydroxylase activity", "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)", "benzoate 4-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: benzoate + H(+) + NADPH + O(2) = 4-hydroxybenzoate + H(2)O + NADP(+). [EC:1.14.14.92, RHEA:18033]", "canonical_name": "p-hydroxybenzoate hydroxylase activity"}
{"concept_id": "C1151094", "aliases": ["2,5-diketocamphane lactonizing enzyme activity", "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)", "camphor ketolactonase I activity", "2,5-diketocamphane 1,2-monooxygenase"], "types": ["T044"], "definition": "Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O. [PMID:3944058, PMID:8515237, RHEA:34415]", "canonical_name": "camphor 1,2-monooxygenase activity"}
{"concept_id": "C1151095", "aliases": ["D-camphor-exo-hydroxylase activity", "camphor 5-exo-hydroxylase activity", "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)", "bornanone 5-exo-hydroxylase activity", "camphor hydroxylase activity", "2-bornanone 5-exo-hydroxylase activity", "d-camphor monooxygenase activity", "methylene hydroxylase activity", "cytochrome p450-cam activity", "camphor 5-exohydroxylase activity", "methylene monooxygenase activity", "camphor 5-exo-methylene hydroxylase activity", "camphor 5-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O. [EC:1.14.15.1]", "canonical_name": "camphor methylene hydroxylase activity"}
{"concept_id": "C1151096", "aliases": ["carbon disulphide oxygenase activity"], "types": ["T044"], "canonical_name": "carbon disulfide oxygenase activity", "definition": "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide. [UM-BBD_reactionID:r0599]"}
{"concept_id": "C1151097", "aliases": [], "types": ["T044"], "definition": "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol. [UM-BBD_enzymeID:e0252]", "canonical_name": "chlorophenol 4-monooxygenase activity"}
{"concept_id": "C1151098", "aliases": ["CMP-Neu5Ac hydroxylase activity", "CMP-N-acetylneuraminic acid hydroxylase activity", "CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)", "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity", "CMP-N-acetylneuraminate hydroxylase activity", "N-acetylneuraminic monooxygenase activity", "CMP-N-acetylneuraminate monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O. [EC:1.14.18.2]", "canonical_name": "cytidine monophosphoacetylneuraminate monooxygenase activity"}
{"concept_id": "C1151099", "aliases": ["cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity", "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)", "cyclohexanone 1,2-monooxygenase activity", "cyclohexanone oxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O. [EC:1.14.13.22]", "canonical_name": "cyclohexanone monooxygenase activity"}
{"concept_id": "C1151100", "aliases": [], "types": ["T044"], "canonical_name": "deethylatrazine monooxygenase activity", "definition": "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine. [UM-BBD_reactionID:r0128]"}
{"concept_id": "C1151101", "aliases": [], "types": ["T044"], "canonical_name": "deisopropylatrazine monooxygenase activity", "definition": "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine. [KEGG_REACTION:R05567]"}
{"concept_id": "C1151102", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O. [RHEA:49076]", "canonical_name": "dibenzothiophene monooxygenase activity"}
{"concept_id": "C1151103", "aliases": [], "types": ["T044"], "canonical_name": "dibenzothiophene-5,5-dioxide monooxygenase activity", "definition": "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate. [UM-BBD_reactionID:r0235]"}
{"concept_id": "C1151104", "aliases": ["dimethyl sulphide monooxygenase activity"], "types": ["T044"], "canonical_name": "dimethyl sulfide monooxygenase activity", "definition": "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde. [UM-BBD_reactionID:r0208]"}
{"concept_id": "C1151105", "aliases": ["N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)", "dimethylaniline N-oxidase activity", "N,N-dimethylaniline monooxygenase activity", "DMA oxidase activity", "dimethylaniline monooxygenase (N-oxide-forming) activity", "dimethylaniline oxidase activity", "methylphenyltetrahydropyridine N-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. [EC:1.14.13.8]", "canonical_name": "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity"}
{"concept_id": "C1151106", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+. [PMID:8692910, PMID:9880351]", "canonical_name": "ferulate 5-hydroxylase activity"}
{"concept_id": "C1151107", "aliases": ["SsuD", "FMNH(2)-dependent alkanesulfonate monooxygenase activity", "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity", "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity", "alkanesulphonate monooxygenase activity", "FMNH2-dependent aliphatic sulfonate monooxygenase activity"], "types": ["T044"], "canonical_name": "alkanesulfonate monooxygenase activity", "definition": "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN. [MetaCyc:RXN0-280]"}
{"concept_id": "C1151108", "aliases": ["GLOX"], "types": ["T044"], "definition": "Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2. [PMID:11733005]", "canonical_name": "glyoxal oxidase activity"}
{"concept_id": "C1151109", "aliases": ["kynurenine hydroxylase activity", "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)", "L-kynurenine-3-hydroxylase activity", "kynurenine 3-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+). [EC:1.14.13.9, RHEA:20545]", "canonical_name": "kynurenine 3-monooxygenase activity"}
{"concept_id": "C1151111", "aliases": ["(+)-limonene 1,2-monooxygenase activity", "(+)-limonene,NAD(P)H:oxygen oxidoreductase activity", "(R)-limonene 1,2-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide. [UM-BBD_enzymeID:e0462]", "canonical_name": "(R)-limonene,NAD(P)H:oxygen oxidoreductase activity"}
{"concept_id": "C1151112", "aliases": ["(-)-limonene 3-monooxygenase activity", "(S)-limonene 3-monooxygenase activity", "(-)-limonene 3-hydroxylase activity", "limonene 3-hydroxylase activity", "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (1S,6R)-isopiperitenol + H(2)O + NADP(+). [EC:1.14.14.99, RHEA:15129]", "canonical_name": "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity"}
{"concept_id": "C1151113", "aliases": ["4-hydroxyacetophenone monooxygenase activity", "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity", "(S)-limonene 6-monooxygenase activity", "(-)-limonene 6-hydroxylase activity", "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity", "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)", "(R)-limonene 6-monooxygenase activity", "HAPMO", "limonene 6-hydroxylase activity", "(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity", "(+)-limonene 6-monooxygenase activity", "(-)-limonene 6-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O. [EC:1.14.14.51]", "canonical_name": "(+)-limonene-6-hydroxylase activity"}
{"concept_id": "C1151115", "aliases": ["luciferase activity"], "types": ["T044"], "definition": "Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation. [GOC:bf]", "canonical_name": "luciferin monooxygenase activity"}
{"concept_id": "C1151116", "aliases": ["methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)", "methane monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O. [EC:1.14.13.25, PMID:10896210]", "canonical_name": "methane hydroxylase activity"}
{"concept_id": "C1151117", "aliases": ["methanesulfonate,FMNH2:oxygen oxidoreductase activity", "methanesulphonic acid monooxygenase activity", "mesylate monooxygenase activity", "methanesulfonate monooxygenase activity", "MSAMO activity", "MSA monooxygenase activity", "methanesulfonate,NADH:oxygen oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O. [EC:1.14.13.111]", "canonical_name": "methanesulfonic acid monooxygenase activity"}
{"concept_id": "C1151118", "aliases": ["N-acetyl-6-hydroxytryptophan oxidase activity", "monophenolase activity", "monophenol monooxygenase activity", "tyrosine-dopa oxidase activity", "monophenol oxygenase", "monophenol monooxidase activity", "tyrosinase activity", "phenol oxidase activity", "monophenol oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. [PMID:4965136, RHEA:18117]", "canonical_name": "L-tyrosine monooxygenase activity"}
{"concept_id": "C1151119", "aliases": ["orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)", "orcinol 2-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + NADH + O(2) + orcinol = 2,3,5-trihydroxytoluene + H(2)O + NAD(+). [EC:1.14.13.6, RHEA:19601]", "canonical_name": "orcinol hydroxylase activity"}
{"concept_id": "C1151120", "aliases": ["PCB4MO activity", "pentachlorophenol dechlorinase activity", "pentachlorophenol 4-monooxygenase activity", "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)", "pentachlorophenol monooxygenase activity", "pentachlorophenol dehalogenase activity", "PCP hydroxylase activity", "PcpB", "PCB 4-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride. [EC:1.14.13.50]", "canonical_name": "pentachlorophenol hydroxylase activity"}
{"concept_id": "C1151121", "aliases": ["PAM-A", "PAM-B", "peptidylglycine alpha-amidating monooxygenase activity", "synthase, peptide alpha-amide", "PAM activity", "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)", "peptidylglycine alpha-hydroxylase activity", "peptidyl alpha-amidating enzyme activity", "peptide alpha-amide synthase activity", "peptidylglycine 2-hydroxylase activity", "peptide-alpha-amide synthetase activity"], "types": ["T044"], "canonical_name": "peptidylglycine monooxygenase activity", "definition": "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. [EC:1.14.17.3]"}
{"concept_id": "C1151122", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene 1,2-monooxygenase activity", "definition": "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide. [UM-BBD_enzymeID:e0333]"}
{"concept_id": "C1151123", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene 3,4-monooxygenase activity", "definition": "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide. [UM-BBD_reactionID:r0508]"}
{"concept_id": "C1151124", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene 9,10-monooxygenase activity", "definition": "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide. [UM-BBD_reactionID:r0495]"}
{"concept_id": "C1151125", "aliases": ["phenol o-hydroxylase activity", "phenol 2-monooxygenase activity", "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O. [EC:1.14.13.7]", "canonical_name": "phenol hydroxylase activity"}
{"concept_id": "C1151126", "aliases": [], "types": ["T044"], "canonical_name": "phenylacetate hydroxylase activity", "definition": "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate. [UM-BBD_reactionID:r0036]"}
{"concept_id": "C1151127", "aliases": ["PAH activity", "phenylalaninase activity", "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)", "phenylalanine 4-hydroxylase activity", "phenylalanine 4-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. [PMID:4004813, RHEA:20273]", "canonical_name": "phenylalanine hydroxylase activity"}
{"concept_id": "C1151128", "aliases": ["salicylate monooxygenase activity", "salicylic hydroxylase activity", "salicylate hydroxylase (decarboxylating)", "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)", "salicylate hydroxylase activity", "salicylate 1-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2. [EC:1.14.13.1]", "canonical_name": "salicylate 1-hydroxylase activity"}
{"concept_id": "C1151129", "aliases": ["squalene epoxidase activity", "squalene-2,3-epoxidase activity", "squalene oxydocyclase activity", "squalene hydroxylase activity", "squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity", "squalene 2,3-oxidocyclase activity", "squalene monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+). [RHEA:25282]", "canonical_name": "squalene-2,3-epoxide cyclase activity"}
{"concept_id": "C1151130", "aliases": [], "types": ["T044"], "definition": "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. [ISBN:0721662544]", "canonical_name": "steroid hydroxylase activity"}
{"concept_id": "C1151131", "aliases": ["cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity", "cholesterol 25-monooxygenase activity"], "types": ["T044"], "canonical_name": "cholesterol 25-hydroxylase activity", "definition": "Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O. [EC:1.14.99.38, RHEA:21104]"}
{"concept_id": "C1151132", "aliases": ["cholesterol 20-22-desmolase activity", "cholesterol C(20-22) desmolase activity", "cholesterol desmolase activity", "desmolase, steroid 20-22", "cytochrome p450scc", "cholesterol monooxygenase (side-chain-cleaving) activity", "cytochrome P-450scc", "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)"], "types": ["T044"], "definition": "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. [EC:1.14.15.6]", "canonical_name": "cholesterol C20-22 desmolase activity"}
{"concept_id": "C1151133", "aliases": ["ecdysone 20-hydroxylase activity", "ecdysone 20-monooxygenase activity", "alpha-ecdysone C-20 hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O. [EC:1.14.99.22, RHEA:14021]", "canonical_name": "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)"}
{"concept_id": "C1151134", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide. [UM-BBD_reactionID:r0225]", "canonical_name": "styrene monooxygenase activity"}
{"concept_id": "C1151135", "aliases": [], "types": ["T044"], "canonical_name": "tetrahydrofuran hydroxylase activity", "definition": "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran. [UM-BBD_reactionID:r0017]"}
{"concept_id": "C1151136", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene. [RHEA:20349]", "canonical_name": "toluene 2-monooxygenase activity"}
{"concept_id": "C1151137", "aliases": [], "types": ["T044"], "canonical_name": "toluene 3-monooxygenase activity", "definition": "Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene. [UM-BBD_enzymeID:e0224]"}
{"concept_id": "C1151138", "aliases": [], "types": ["T044"], "canonical_name": "toluene 4-monooxygenase activity", "definition": "Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene. [UM-BBD_enzymeID:e0225]"}
{"concept_id": "C1151139", "aliases": ["toluene-4-sulphonate monooxygenase activity"], "types": ["T044"], "canonical_name": "toluene-4-sulfonate monooxygenase activity", "definition": "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene. [UM-BBD_reactionID:r0296]"}
{"concept_id": "C1151140", "aliases": ["toluene-sulphonate methyl-monooxygenase activity"], "types": ["T044"], "canonical_name": "toluene-sulfonate methyl-monooxygenase activity", "definition": "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol. [RHEA:51024]"}
{"concept_id": "C1151141", "aliases": ["tryptophan 5-hydroxylase activity", "tryptophan 5-monooxygenase activity", "indoleacetic acid-5-hydroxylase activity", "tryptophan hydroxylase activity", "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.4]", "canonical_name": "L-tryptophan hydroxylase activity"}
{"concept_id": "C1151142", "aliases": ["tyrosine 3-monooxygenase activity", "tyrosine hydroxylase activity", "L-tyrosine hydroxylase activity", "tyrosine 3-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.2]", "canonical_name": "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)"}
{"concept_id": "C1151144", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol. [UM-BBD_enzymeID:e0172]", "canonical_name": "xylene monooxygenase activity"}
{"concept_id": "C1151145", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+. [MetaCyc:RXN0-5101]", "canonical_name": "N-ethylmaleimide reductase activity"}
{"concept_id": "C1151146", "aliases": ["NAD(P)H oxidase activity", "NAD(P)H:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "NADPH oxidase"}
{"concept_id": "C1151147", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. [GOC:ai, PMID:10806195]", "canonical_name": "superoxide-generating NAD(P)H oxidase activity"}
{"concept_id": "C1151148", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on CH-OH group of donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151149", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2. [UM-BBD_reactionID:r0032]", "canonical_name": "1-phenylethanol dehydrogenase activity"}
{"concept_id": "C1151150", "aliases": [], "types": ["T044"], "canonical_name": "chloral hydrate dehydrogenase activity", "definition": "Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol. [UM-BBD_enzymeID:e0229]"}
{"concept_id": "C1151151", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethylmethylsilanediol oxidase activity", "definition": "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O. [UM-BBD_reactionID:r0638]"}
{"concept_id": "C1151152", "aliases": ["N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)", "isopenicillin-N synthase activity", "isopenicillin N synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N. [EC:1.21.3.1, RHEA:22428]", "canonical_name": "isopenicillin-N synthetase activity"}
{"concept_id": "C1151153", "aliases": [], "types": ["T044"], "canonical_name": "ketoreductase activity", "definition": "Catalysis of the reduction of a ketone group to form the corresponding alcohol. [GOC:curators]"}
{"concept_id": "C1151154", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. [GOC:ai, GOC:bf]", "canonical_name": "lactate dehydrogenase activity"}
{"concept_id": "C1151155", "aliases": ["cytochrome-dependent D-(-)-lactate dehydrogenase activity", "D-lactate ferricytochrome c oxidoreductase activity", "D-lactate (cytochrome) dehydrogenase activity", "D-(-)-lactic cytochrome c reductase activity", "D-lactate dehydrogenase (cytochrome) activity", "D-lactate-cytochrome c reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. [RHEA:13521]", "canonical_name": "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity"}
{"concept_id": "C1151156", "aliases": ["L-lactic acid dehydrogenase activity", "L-lactate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. [EC:1.1.1.27, RHEA:23444]", "canonical_name": "L-lactic dehydrogenase activity"}
{"concept_id": "C1151157", "aliases": ["lactate dehydrogenase (cytochrome)", "lactic cytochrome c reductase activity", "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity", "dehydrogenase, lactate (cytochrome)", "L-lactate cytochrome c reductase activity", "L-lactate cytochrome c oxidoreductase activity", "L-lactate dehydrogenase (cytochrome) activity", "L-lactate ferricytochrome c oxidoreductase activity", "L(+)-lactate:cytochrome c oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. [RHEA:19909]", "canonical_name": "flavocytochrome b2"}
{"concept_id": "C1151158", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. [GOC:mah, ISBN:0582227089]", "canonical_name": "malate dehydrogenase activity"}
{"concept_id": "C1151159", "aliases": ["D-malate dehydrogenase activity", "(R)-malate:NAD+ oxidoreductase (decarboxylating)", "D-malic enzyme"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-malate + NAD(+) = CO(2) + NADH + pyruvate. [EC:1.1.1.83, RHEA:18365]", "canonical_name": "D-malate dehydrogenase (decarboxylating) activity"}
{"concept_id": "C1151160", "aliases": ["NAD-dependent malic dehydrogenase activity", "NAD-malic dehydrogenase activity", "MDH", "L-malate-NAD+ oxidoreductase activity", "(S)-malate:NAD+ oxidoreductase activity", "NAD-malate dehydrogenase activity", "L-malate dehydrogenase activity", "NAD-linked malate dehydrogenase activity", "malic dehydrogenase activity", "NAD-specific malate dehydrogenase activity", "NAD-dependent malate dehydrogenase activity", "NAD-L-malate dehydrogenase activity", "malate (NAD) dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. [EC:1.1.1.37]", "canonical_name": "malic acid dehydrogenase activity"}
{"concept_id": "C1151162", "aliases": ["NADP-linked malate dehydrogenase activity", "NADP malate dehydrogenase activity", "malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)", "malate NADP dehydrogenase activity", "malate dehydrogenase (NADP+) activity", "(S)-malate:NADP+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. [EC:1.1.1.82]", "canonical_name": "NADP-malate dehydrogenase activity"}
{"concept_id": "C1151163", "aliases": ["malic enzyme activity"], "types": ["T044"], "definition": "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. [ISBN:0198506732]", "canonical_name": "pyruvic-malic carboxylase activity"}
{"concept_id": "C1151164", "aliases": ["(S)-malate:NAD+ oxidoreductase (decarboxylating)", "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)", "'malic' enzyme", "malate dehydrogenase (decarboxylating) (NAD+) activity", "malate dehydrogenase (oxaloacetate-decarboxylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. [EC:1.1.1.38, EC:1.1.1.39]", "canonical_name": "malate dehydrogenase (decarboxylating) activity"}
{"concept_id": "C1151166", "aliases": ["malate dehydrogenase (NADP, decarboxylating)", "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "NADP-specific malate dehydrogenase activity", "L-malate:NADP oxidoreductase activity", "malate dehydrogenase (decarboxylating, NADP)", "NADP-malic enzyme activity"], "types": ["T044"], "canonical_name": "malate dehydrogenase (decarboxylating) (NADP+) activity", "definition": "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. [EC:1.1.1.40]"}
{"concept_id": "C1151167", "aliases": [], "types": ["T044"], "canonical_name": "myrtenol dehydrogenase activity", "definition": "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal. [UM-BBD_reactionID:r0710]"}
{"concept_id": "C1151168", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule. [GOC:ai]"}
{"concept_id": "C1151169", "aliases": ["oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule. [GOC:ai]"}
{"concept_id": "C1151170", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. [EC:1.1.1.-, GOC:ai]"}
{"concept_id": "C1151171", "aliases": ["L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity", "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity", "(R)-aminopropanol dehydrogenase activity", "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity", "1-aminopropan-2-ol-dehydrogenase activity", "L-aminopropanol dehydrogenase activity", "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH. [EC:1.1.1.75, RHEA:16517]", "canonical_name": "1-aminopropan-2-ol-NAD+ dehydrogenase activity"}
{"concept_id": "C1151172", "aliases": ["D-butanediol dehydrogenase activity", "2,3-butanediol dehydrogenase activity", "butylene glycol dehydrogenase activity", "1-amino-2-propanol dehydrogenase activity", "D-1-amino-2-propanol dehydrogenase activity", "(R)-diacetyl reductase activity", "(R)-2,3-butanediol dehydrogenase activity", "butyleneglycol dehydrogenase activity", "1-amino-2-propanol oxidoreductase activity", "D-(-)-butanediol dehydrogenase activity", "aminopropanol oxidoreductase activity", "D-aminopropanol dehydrogenase activity", "(R,R)-butanediol dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+). [EC:1.1.1.4]", "canonical_name": "D-1-amino-2-propanol:NAD(2) oxidoreductase activity"}
{"concept_id": "C1151173", "aliases": ["DOXP reductoisomerase activity", "1-deoxyxylulose-5-phosphate reductoisomerase activity", "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity", "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)", "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity", "DXP-reductoisomerase activity"], "types": ["T044"], "canonical_name": "1-deoxy-D-xylulose-5-phosphate reductoisomerase activity", "definition": "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH. [EC:1.1.1.267, RHEA:13717]"}
{"concept_id": "C1151174", "aliases": ["15-hydroxyprostaglandin dehydrogenase activity", "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity", "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity", "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity", "15-hydroxyprostaglandin dehydrogenase (NAD+) activity", "15-hydroxyprostanoic dehydrogenase activity", "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)"], "types": ["T044"], "definition": "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+. [EC:1.1.1.141]", "canonical_name": "prostaglandin dehydrogenase activity"}
{"concept_id": "C1151175", "aliases": ["(R)-pantoate:NADP+ 2-oxidoreductase activity", "KPA reductase activity", "2-ketopantoate reductase activity", "ketopantoic acid reductase activity", "ketopantoate reductase activity", "2-oxopantoate reductase activity", "2-ketopantoic acid reductase activity"], "types": ["T044"], "canonical_name": "2-dehydropantoate 2-reductase activity", "definition": "Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH. [EC:1.1.1.169, RHEA:16233]"}
{"concept_id": "C1151176", "aliases": ["2-oxopantoyl lactone reductase", "2-dehydropantolactone reductase (B-specific) activity", "2-dehydropantoyl-lactone reductase (B-specific) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+. [EC:1.1.1.214]", "canonical_name": "(R)-pantolactone:NADP+ oxidoreductase (B-specific)"}
{"concept_id": "C1151177", "aliases": ["2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity", "2-deoxygluconate dehydrogenase activity", "2-keto-3-deoxygluconate oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-deoxy-D-gluconate 3-dehydrogenase activity", "definition": "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+. [EC:1.1.1.125]"}
{"concept_id": "C1151178", "aliases": ["(R)-glycerate:NAD(P)+ oxidoreductase activity", "2-hydroxy-3-oxopropionate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+. [EC:1.1.1.60]", "canonical_name": "tartronate semialdehyde reductase (NADPH) activity"}
{"concept_id": "C1151179", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxytetrahydrofuran dehydrogenase activity", "definition": "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone. [UM-BBD_reactionID:r0018]"}
{"concept_id": "C1151180", "aliases": ["imidazol-5-yl lactate dehydrogenase activity", "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+. [EC:1.1.1.111]", "canonical_name": "3-(imidazol-5-yl)lactate dehydrogenase activity"}
{"concept_id": "C1151181", "aliases": ["beta-hydroxyacylcoenzyme A dehydrogenase activity", "beta-hydroxyacyl-coenzyme A synthetase activity", "L-3-hydroxyacyl CoA dehydrogenase activity", "L-3-hydroxyacyl coenzyme A dehydrogenase activity", "3-hydroxyacyl-CoA dehydrogenase activity", "beta-keto-reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). [EC:1.1.1.35]", "canonical_name": "beta-hydroxyacyl dehydrogenase activity"}
{"concept_id": "C1151182", "aliases": ["long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity", "long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity", "LCHAD"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [EC:1.1.1.211, GOC:pde]", "canonical_name": "beta-hydroxyacyl-CoA dehydrogenase activity"}
{"concept_id": "C1151183", "aliases": ["3-hydroxybutyrate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH. [EC:1.1.1.30, RHEA:20521]", "canonical_name": "D-beta-hydroxybutyrate dehydrogenase activity"}
{"concept_id": "C1151184", "aliases": ["L(+)-3-hydroxybutyryl-CoA dehydrogenase activity", "BHBD activity", "beta-hydroxybutyryl-CoA dehydrogenase activity", "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity", "3-hydroxybutyryl-CoA dehydrogenase activity", "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)", "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+. [EC:1.1.1.157]", "canonical_name": "beta-hydroxybutyryl coenzyme A dehydrogenase activity"}
{"concept_id": "C1151185", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. [EC:1.1.1.31]", "canonical_name": "3-hydroxyisobutyrate dehydrogenase activity"}
{"concept_id": "C1151186", "aliases": ["3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "3-hydroxypimeloyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD(+) = 3-oxopimelyl-CoA + H(+) + NADH. [EC:1.1.1.259, RHEA:11168]"}
{"concept_id": "C1151187", "aliases": ["threo-Ds-3-isopropylmalate dehydrogenase activity", "IPMDH", "IMDH activity", "3-isopropylmalate dehydrogenase activity", "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity", "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity", "beta-IPM dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+. [EC:1.1.1.85, RHEA:32271]", "canonical_name": "beta-isopropylmalate dehydrogenase activity"}
{"concept_id": "C1151190", "aliases": ["4-(hydroxymethyl)benzenesulfonate dehydrogenase activity", "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity", "4-sulfobenzyl alcohol dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH. [EC:1.1.1.257, RHEA:24412]", "canonical_name": "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity"}
{"concept_id": "C1151191", "aliases": ["hydroxy-L-proline oxidase activity", "4-hydroxy-L-proline:NAD+ oxidoreductase activity", "4-oxoproline reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+. [EC:1.1.1.104]", "canonical_name": "hydroxyproline oxidase activity"}
{"concept_id": "C1151192", "aliases": ["5-amino-6-(5'-phosphoribosylamino)uracil reductase activity", "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity", "aminodioxyphosphoribosylaminopyrimidine reductase activity"], "types": ["T044"], "canonical_name": "5-amino-6-(5-phosphoribosylamino)uracil reductase activity", "definition": "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH. [EC:1.1.1.193, RHEA:17845]"}
{"concept_id": "C1151193", "aliases": [], "types": ["T044"], "canonical_name": "5-exo-hydroxycamphor dehydrogenase activity", "definition": "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane. [UM-BBD_reactionID:r0427]"}
{"concept_id": "C1151194", "aliases": ["6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 6-endo-hydroxycineole + NAD(+) = 6-oxocineole + H(+) + NADH. [EC:1.1.1.241, RHEA:11736]", "canonical_name": "6-endo-hydroxycineole dehydrogenase activity"}
{"concept_id": "C1151195", "aliases": ["6-hydroxyhexanoate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "6-hydroxyhexanoate dehydrogenase activity", "definition": "Catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH. [EC:1.1.1.258, RHEA:14225]"}
{"concept_id": "C1151196", "aliases": ["2-keto-6-phosphogluconate reductase activity", "6-phosphogluconate 2-dehydrogenase activity", "6-phosphogluconate dehydrogenase (NAD)", "phosphogluconate dehydrogenase activity", "gluconate 6-phosphate dehydrogenase activity", "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "phosphogluconate 2-dehydrogenase activity", "definition": "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH. [EC:1.1.1.43]"}
{"concept_id": "C1151197", "aliases": ["9-fluorenol dehydrogenase activity", "fluoren-9-ol:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "fluoren-9-ol dehydrogenase activity", "definition": "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+. [EC:1.1.1.256]"}
{"concept_id": "C1151198", "aliases": ["NADPH:acetoacetyl-CoA reductase activity", "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity", "(R)-3-hydroxyacyl-CoA dehydrogenase activity", "hydroxyacyl coenzyme-A dehydrogenase activity", "acetoacetyl coenzyme A reductase activity", "NADP-linked acetoacetyl CoA reductase activity", "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity", "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity", "D-3-hydroxyacyl-CoA reductase activity", "acetoacetyl-CoA reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+. [EC:1.1.1.36]", "canonical_name": "beta-ketoacyl-CoA reductase"}
{"concept_id": "C1151199", "aliases": ["acetoin dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. [EC:1.1.1.303, EC:1.1.1.304, MetaCyc:ACETOINDEHYDROG-RXN]", "canonical_name": "diacetyl reductase activity"}
{"concept_id": "C1151200", "aliases": ["acyldihydroxyacetone phosphate reductase activity", "acylglycerone-phosphate reductase activity", "1-acyldihydroxyacetone-phosphate reductase activity", "palmitoyldihydroxyacetone-phosphate reductase activity", "palmitoyl dihydroxyacetone phosphate reductase activity", "palmitoyl-dihydroxyacetone-phosphate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+). [EC:1.1.1.101]", "canonical_name": "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity"}
{"concept_id": "C1151202", "aliases": ["alcohol:NADP dehydrogenase activity", "aldehyde reductase (NADPH2) activity", "aldehyde reductase (NADPH) activity", "alcohol dehydrogenase (NADP+) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. [EC:1.1.1.2]", "canonical_name": "NADP-aldehyde reductase activity"}
{"concept_id": "C1151203", "aliases": [], "types": ["T044"], "canonical_name": "alcohol dehydrogenase activity, iron-dependent", "definition": "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron. [EC:1.1.1.1, GOC:mah]"}
{"concept_id": "C1151204", "aliases": [], "types": ["T044"], "canonical_name": "alcohol dehydrogenase activity, metal ion-independent", "definition": "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion. [EC:1.1.1.1, GOC:mah]"}
{"concept_id": "C1151205", "aliases": [], "types": ["T044"], "canonical_name": "alcohol dehydrogenase activity, zinc-dependent", "definition": "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. [EC:1.1.1.1, GOC:mah]"}
{"concept_id": "C1151208", "aliases": ["nonspecific NADPH-dependent carbonyl reductase activity", "ALR3", "NADPH2-dependent carbonyl reductase activity", "aldehyde reductase 1", "secondary-alcohol:NADP+ oxidoreductase activity", "NADPH-dependent carbonyl reductase activity", "carbonyl reductase (NADPH) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+. [EC:1.1.1.184]", "canonical_name": "carbonyl reductase activity"}
{"concept_id": "C1151209", "aliases": ["(-)-trans-carveol:NADP+ oxidoreductase activity", "carveol dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH. [EC:1.1.1.243, RHEA:13629]", "canonical_name": "(-)-trans-carveol dehydrogenase activity"}
{"concept_id": "C1151210", "aliases": ["cinnamyl-alcohol:NADP+ oxidoreductase activity", "cinnamyl-alcohol dehydrogenase activity", "CAD activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+. [EC:1.1.1.195]", "canonical_name": "cinnamyl alcohol dehydrogenase activity"}
{"concept_id": "C1151211", "aliases": ["cyclohexanol dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+. [EC:1.1.1.245]", "canonical_name": "cyclohexanol:NAD+ oxidoreductase activity"}
{"concept_id": "C1151212", "aliases": ["D-arabinose:NAD(P)+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "D-arabinose 1-dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+. [EC:1.1.1.117]"}
{"concept_id": "C1151213", "aliases": ["D-galactose:NAD+ 1-oxidoreductase activity", "NAD-dependent D-galactose dehydrogenase activity", "D-galactose dehydrogenase activity", "D-galactose 1-dehydrogenase activity", "beta-galactose dehydrogenase activity"], "types": ["T044"], "canonical_name": "galactose 1-dehydrogenase activity", "definition": "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+. [EC:1.1.1.48]"}
{"concept_id": "C1151214", "aliases": ["methylglyoxal reductase (NADH-dependent) activity", "(R)-lactaldehyde:NAD+ oxidoreductase activity", "methylglyoxal reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+. [EC:1.1.1.78]", "canonical_name": "D-lactaldehyde dehydrogenase activity"}
{"concept_id": "C1151215", "aliases": ["D-lactic acid dehydrogenase activity", "D-lactic dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate. [EC:1.1.1.28, RHEA:16369]", "canonical_name": "D-lactate dehydrogenase activity"}
{"concept_id": "C1151216", "aliases": ["xylitol dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH. [EC:1.1.1.9, RHEA:20433]", "canonical_name": "D-xylulose reductase activity"}
{"concept_id": "C1151217", "aliases": ["dihydroflavanol 4-reductase activity", "NADPH-dihydromyricetin reductase activity", "dihydromyricetin reductase activity", "dihydroflavonol 4-reductase activity", "cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity", "dihydroquercetin reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+. [EC:1.1.1.219]", "canonical_name": "dihydrokaempferol 4-reductase activity"}
{"concept_id": "C1151218", "aliases": ["dTDP-6-deoxy-L-mannose dehydrogenase activity", "dTDP-4-dehydrorhamnose reductase activity", "thymidine diphospho-4-ketorhamnose reductase activity", "reductase, thymidine diphospho-4-ketorhamnose", "dTDP-4-ketorhamnose reductase activity", "TDP-4-keto-rhamnose reductase activity", "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH. [EC:1.1.1.133, RHEA:21796]", "canonical_name": "dTDP-4-keto-L-rhamnose reductase activity"}
{"concept_id": "C1151219", "aliases": [], "types": ["T044"], "canonical_name": "epoxide dehydrogenase activity", "definition": "Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA. [UM-BBD_reactionID:r0595]"}
{"concept_id": "C1151220", "aliases": ["fructuronate reductase activity", "D-mannonate dehydrogenase activity", "D-mannonate:NAD+ 5-oxidoreductase activity", "mannonate oxidoreductase activity", "mannonic dehydrogenase activity", "D-mannonate oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH. [EC:1.1.1.57, RHEA:15729]", "canonical_name": "D-mannonate:NAD oxidoreductase activity"}
{"concept_id": "C1151221", "aliases": ["galactitol-1-phosphate 5-dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+. [EC:1.1.1.251]", "canonical_name": "galactitol-1-phosphate:NAD+ oxidoreductase activity"}
{"concept_id": "C1151222", "aliases": ["GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity", "GDP-4-keto-D-rhamnose reductase activity", "GDP-4-keto-6-deoxy-D-mannose reductase activity", "guanosine diphosphate-4-keto-D-rhamnose reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed. [BRENDA:1.1.1.187, EC:1.1.1.187]", "canonical_name": "GDP-4-dehydro-D-rhamnose reductase activity"}
{"concept_id": "C1151223", "aliases": [], "types": ["T044"], "canonical_name": "gluconate dehydrogenase activity", "definition": "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+. [EC:1.1.1.215, EC:1.1.1.69]"}
{"concept_id": "C1151224", "aliases": ["2-keto-D-gluconate reductase activity", "2-ketogluconate reductase activity", "D-gluconate:NADP+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+. [EC:1.1.1.215]", "canonical_name": "gluconate 2-dehydrogenase activity"}
{"concept_id": "C1151225", "aliases": ["D-gluconate:NAD(P)+ 5-oxidoreductase", "5-keto-D-gluconate 5-reductase activity", "5-ketogluconate reductase activity", "5-ketogluconate 5-reductase activity", "5-keto-D-gluconate reductase"], "types": ["T044"], "definition": "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+. [EC:1.1.1.69]", "canonical_name": "gluconate 5-dehydrogenase activity"}
{"concept_id": "C1151226", "aliases": ["D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity", "6-phosphoglucose dehydrogenase activity", "G6PDH", "glucose-6-phosphate dehydrogenase activity", "NADP-dependent glucose 6-phosphate dehydrogenase activity", "glucose-6-phosphate 1-dehydrogenase activity", "Entner-doudoroff enzyme", "GDH", "Zwischenferment", "G6PD activity", "glucose 6-phosphate dehydrogenase (NADP) activity", "D-glucose 6-phosphate dehydrogenase activity", "6-phosphoglucose dehydrogenas"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. [EC:1.1.1.49]", "canonical_name": "NADP-glucose-6-phosphate dehydrogenase activity"}
{"concept_id": "C1151227", "aliases": ["hydroxypyruvate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+. [EC:1.1.1.29]", "canonical_name": "glycerate dehydrogenase activity"}
{"concept_id": "C1151228", "aliases": [], "types": ["T044"], "canonical_name": "glycerol dehydrogenase activity"}
{"concept_id": "C1151231", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. [EC:1.1.1.23]", "canonical_name": "histidinol dehydrogenase activity"}
{"concept_id": "C1151232", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. [EC:1.1.1.3]", "canonical_name": "homoserine dehydrogenase activity"}
{"concept_id": "C1151233", "aliases": ["3-hydroxy-3-methylglutaryl coenzyme A reductase activity"], "types": ["T044"], "canonical_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity"}
{"concept_id": "C1151234", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH. [PMID:29224355, RHEA:15989]", "canonical_name": "hydroxymethylglutaryl-CoA reductase (NADPH) activity"}
{"concept_id": "C1151235", "aliases": ["hydroxypyruvate reductase activity", "NADH:hydroxypyruvate reductase activity", "D-glycerate:NADP+ 2-oxidoreductase activity", "beta-hydroxypyruvate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+. [EC:1.1.1.81]", "canonical_name": "D-glycerate dehydrogenase activity"}
{"concept_id": "C1151236", "aliases": ["IMP oxidoreductase activity", "inosine monophosphate oxidoreductase activity", "inosine 5'-monophosphate dehydrogenase activity", "IMP:NAD+ oxidoreductase activity", "IMP dehydrogenase activity", "inosine-5'-phosphate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. [EC:1.1.1.205]", "canonical_name": "inosine monophosphate dehydrogenase activity"}
{"concept_id": "C1151237", "aliases": ["IDH activity", "isocitric dehydrogenase activity", "oxalosuccinate carboxylase activity", "oxalosuccinic decarboxylase activity", "isocitric acid dehydrogenase activity", "IDP activity", "isocitrate dehydrogenase [NAD(P)+] activity", "oxalosuccinate decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H. [GOC:curators]", "canonical_name": "isocitrate dehydrogenase activity"}
{"concept_id": "C1151238", "aliases": ["NAD-specific isocitrate dehydrogenase activity", "NAD dependent isocitrate dehydrogenase activity", "isocitrate:NAD+ oxidoreductase (decarboxylating)", "isocitrate dehydrogenase (NAD+) activity", "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity", "isocitrate dehydrogenase (NAD) activity", "NAD isocitrate dehydrogenase activity", "NAD-linked isocitrate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH. [RHEA:23632]", "canonical_name": "NAD isocitric dehydrogenase activity"}
{"concept_id": "C1151239", "aliases": ["NADP(+)-linked isocitrate dehydrogenase activity", "NADP-dependent isocitrate dehydrogenase activity", "isocitrate dehydrogenase (NADP-dependent) activity", "isocitrate dehydrogenase (NADP) activity", "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity", "isocitrate dehydrogenase (NADP+) activity", "NADP-dependent isocitric dehydrogenase activity", "triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity", "NADP isocitric dehydrogenase activity", "isocitrate:NADP+ oxidoreductase (decarboxylating)", "isocitrate (NADP) dehydrogenase activity", "NADP(+)-ICDH activity", "NADP-specific isocitrate dehydrogenase activity", "NADP-linked isocitrate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. [RHEA:19629]", "canonical_name": "NADP(+)-IDH activity"}
{"concept_id": "C1151240", "aliases": ["isopiperitenol dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD(+) = (6R)-isoperitenone + H(+) + NADH. [EC:1.1.1.223, RHEA:20860]", "canonical_name": "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity"}
{"concept_id": "C1151241", "aliases": ["ketol acid reductoisomerase activity", "reductoisomerase activity", "acetohydroxy acid isomeroreductase activity", "alpha-keto-beta-hydroxylacyl reductoisomerase activity", "acetohydroxy acid reductoisomerase activity", "2-hydroxy-3-keto acid reductoisomerase activity", "dihydroxyisovalerate dehydrogenase (isomerizing) activity", "isomeroreductase activity", "dihydroxyisovalerate (isomerizing) dehydrogenase activity", "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)", "acetolactate reductoisomerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. [EC:1.1.1.86]", "canonical_name": "ketol-acid reductoisomerase activity"}
{"concept_id": "C1151242", "aliases": ["L-iditol:NAD+ 5-oxidoreductase activity", "L-iditol 2-dehydrogenase activity", "L-iditol:NAD oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. [EC:1.1.1.14]", "canonical_name": "sorbitol dehydrogenase activity"}
{"concept_id": "C1151243", "aliases": ["L-threonine:NAD+ oxidoreductase activity", "threonine dehydrogenase activity", "L-threonine 3-dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + CO(2) + NADH. [EC:1.1.1.103, RHEA:13161]", "canonical_name": "L-threonine dehydrogenase activity"}
{"concept_id": "C1151244", "aliases": ["lactaldehyde reductase activity", "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity", "(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+. [EC:1.1.1.77]", "canonical_name": "lactaldehyde:propanediol oxidoreductase activity"}
{"concept_id": "C1151245", "aliases": ["mannitol:NAD+ 1-oxidoreductase activity", "MTD activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH. [EC:1.1.1.255, RHEA:15029]", "canonical_name": "mannitol dehydrogenase activity"}
{"concept_id": "C1151246", "aliases": [], "types": ["T044"], "canonical_name": "mannitol-1-phosphate 5-dehydrogenase activity", "definition": "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. [EC:1.1.1.17]"}
{"concept_id": "C1151247", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor. [EC:1.1.1.32, EC:1.1.1.33]", "canonical_name": "mevaldate reductase activity"}
{"concept_id": "C1151248", "aliases": [], "types": ["T044"], "canonical_name": "mevaldate reductase (NAD+) activity", "definition": "Catalysis of the reaction: (R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH. [EC:1.1.1.32, RHEA:13221]"}
{"concept_id": "C1151249", "aliases": ["mevaldate reductase (NADPH) activity", "(R)-mevalonate:NADP+ oxidoreductase"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH. [EC:1.1.1.33, RHEA:20193]", "canonical_name": "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase"}
{"concept_id": "C1151251", "aliases": ["1-octanol dehydrogenase activity", "octanol:NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH. [EC:1.1.1.73, RHEA:24620]", "canonical_name": "octanol dehydrogenase activity"}
{"concept_id": "C1151252", "aliases": ["perillyl-alcohol:NAD+ oxidoreductase activity", "perillyl alcohol dehydrogenase activity"], "types": ["T044"], "canonical_name": "perillyl-alcohol dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde. [EC:1.1.1.144, RHEA:10664]"}
{"concept_id": "C1151253", "aliases": ["6-phospho-D-gluconate dehydrogenase activity", "phosphogluconic acid dehydrogenase activity", "6-phosphogluconic carboxylase activity", "6-phosphogluconate dehydrogenase (decarboxylating)", "phosphogluconate dehydrogenase (decarboxylating) activity", "6PGD activity", "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. [EC:1.1.1.44]", "canonical_name": "6-phosphogluconic dehydrogenase activity"}
{"concept_id": "C1151254", "aliases": ["glycerate-1,3-phosphate dehydrogenase activity", "SerA", "SerA 3PG dehydrogenase activity", "3-phosphoglyceric acid dehydrogenase activity", "alpha-KG reductase activity", "3PHP reductase activity", "phosphoglycerate dehydrogenase activity", "D-3-phosphoglycerate dehydrogenase activity", "alpha-phosphoglycerate dehydrogenase activity", "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity", "alphaKG reductase activity", "phosphoglycerate oxidoreductase activity", "phosphoglyceric acid dehydrogenase activity", "3-phosphoglycerate dehydrogenase activity", "PGDH activity", "3-phosphoglycerate:NAD+ 2-oxidoreductase activity", "D-3-phosphoglycerate:NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. [EC:1.1.1.95]", "canonical_name": "glycerate 3-phosphate dehydrogenase activity"}
{"concept_id": "C1151256", "aliases": [], "types": ["T044"], "canonical_name": "retinol dehydrogenase activity"}
{"concept_id": "C1151257", "aliases": ["sepiapterin reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+. [EC:1.1.1.153]", "canonical_name": "7,8-dihydrobiopterin:NADP+ oxidoreductase activity"}
{"concept_id": "C1151259", "aliases": ["D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity", "sorbitol-6-P-dehydrogenase activity", "D-glucitol-6-phosphate dehydrogenase activity", "glucitol-6-phosphate dehydrogenase activity", "D-sorbitol 6-phosphate dehydrogenase activity", "ketosephosphate reductase activity", "D-sorbitol-6-phosphate dehydrogenase activity"], "types": ["T044"], "canonical_name": "sorbitol-6-phosphate 2-dehydrogenase activity", "definition": "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. [EC:1.1.1.140]"}
{"concept_id": "C1151260", "aliases": [], "types": ["T044"], "canonical_name": "steroid dehydrogenase activity", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. [GOC:mah]"}
{"concept_id": "C1151261", "aliases": ["11beta-hydroxysteroid dehydrogenase", "corticosteroid 11-reductase", "11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+). [PMID:15761036]", "canonical_name": "11beta-hydroxy steroid dehydrogenase"}
{"concept_id": "C1151262", "aliases": ["17beta-hydroxy steroid dehydrogenase", "3beta-hydroxy steroid dehydrogenase", "testosterone dehydrogenase [NAD(P)] activity", "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase", "3(or 17)beta-hydroxysteroid dehydrogenase activity", "3beta-hydroxysteroid dehydrogenase"], "types": ["T044"], "definition": "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. [EC:1.1.1.51]", "canonical_name": "beta-hydroxy steroid dehydrogenase"}
{"concept_id": "C1151263", "aliases": ["5-ene-3-beta-hydroxysteroid dehydrogenase activity", "3-beta-hydroxy-D5-steroid dehydrogenase activity", "delta5-3beta-hydroxysteroid dehydrogenase activity", "3-beta-hydroxy-5-ene steroid dehydrogenase activity", "steroid-delta5-3beta-ol dehydrogenase activity", "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity", "3beta-hydroxy-5-ene-steroid oxidoreductase activity", "3beta-hydroxy steroid dehydrogenase/isomerase activity", "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity", "3beta-hydroxy-5-ene steroid dehydrogenase activity", "3beta-hydroxy-delta5-steroid dehydrogenase activity", "3beta-hydroxy-5-ene-steroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "3-beta-hydroxy-delta5-steroid dehydrogenase activity", "definition": "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+). [EC:1.1.1.145]"}
{"concept_id": "C1151264", "aliases": ["7alpha-hydroxy steroid dehydrogenase activity", "7alpha-hydroxysteroid dehydrogenase activity", "7-alpha-hydroxysteroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "7alpha-HSDH"}
{"concept_id": "C1151265", "aliases": ["estradiol dehydrogenase activity", "17-beta-hydroxysteroid dehydrogenase activity", "estradiol 17-beta-dehydrogenase activity", "17beta,20alpha-hydroxysteroid dehydrogenase activity", "estrogen 17-oxidoreductase activity", "17-beta-HSD activity", "17beta-hydroxysteroid dehydrogenase activity", "17beta-HSD", "17-beta-estradiol dehydrogenase activity", "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity", "estradiol 17beta-dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. [EC:1.1.1.62]", "canonical_name": "17beta-estradiol dehydrogenase activity"}
{"concept_id": "C1151266", "aliases": ["altronic oxidoreductase activity", "D-altronate:NAD+ 3-oxidoreductase activity", "altronate oxidoreductase activity", "tagaturonate dehydrogenase activity", "TagUAR", "altronate dehydrogenase activity", "D-tagaturonate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH. [EC:1.1.1.58, RHEA:17813]", "canonical_name": "tagaturonate reductase activity"}
{"concept_id": "C1151267", "aliases": ["mesotartrate dehydrogenase activity", "tartrate:NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+. [EC:1.1.1.93]", "canonical_name": "tartrate dehydrogenase activity"}
{"concept_id": "C1151268", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose 6-dehydrogenase activity", "definition": "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate. [EC:1.1.1.22, RHEA:23596]"}
{"concept_id": "C1151269", "aliases": ["UDP-N-acetylenolpyruvoylglucosamine reductase activity", "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity", "UDP-N-acetylglucosamine-enoylpyruvate reductase activity", "uridine diphosphoacetylpyruvoylglucosamine reductase activity", "UDP-GlcNAc-enoylpyruvate reductase activity", "UDP-N-acetylmuramate dehydrogenase activity", "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. [EC:1.3.1.98]", "canonical_name": "UDP-N-acetylmuramate:NADP+ oxidoreductase activity"}
{"concept_id": "C1151270", "aliases": ["(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+. [EC:1.1.1.154, PMID:23284870]", "canonical_name": "ureidoglycolate dehydrogenase activity"}
{"concept_id": "C1151271", "aliases": ["xanthine oxidoreductase activity", "xanthine-NAD oxidoreductase activity", "NAD-xanthine dehydrogenase activity", "xanthine:NAD+ oxidoreductase activity", "xanthine dehydrogenase activity", "xanthine/NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. [EC:1.17.1.4]", "canonical_name": "xanthine/NAD(+) oxidoreductase activity"}
{"concept_id": "C1151272", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound. [GOC:ai]"}
{"concept_id": "C1151273", "aliases": ["quinoprotein alcohol dehydrogenase activity"], "types": ["T044"], "canonical_name": "alcohol dehydrogenase (acceptor) activity"}
{"concept_id": "C1151274", "aliases": ["choline:(acceptor) 1-oxidoreductase activity", "choline:(acceptor) oxidoreductase activity", "choline dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde. [EC:1.1.99.1, RHEA:17433]", "canonical_name": "choline:acceptor 1-oxidoreductase activity"}
{"concept_id": "C1151276", "aliases": ["glucose dehydrogenase (acceptor) activity", "soluble glucose dehydrogenase"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor. [PMID:22027299]", "canonical_name": "glucose dehydrogenase activity"}
{"concept_id": "C1151277", "aliases": ["quinoprotein glucose dehydrogenase activity", "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity", "glucose dehydrogenase (PQQ-dependent) activity", "quinoprotein D-glucose dehydrogenase activity", "D-glucose:ubiquinone oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol. [EC:1.1.5.2]", "canonical_name": "glucose dehydrogenase (pyrroloquinoline-quinone) activity"}
{"concept_id": "C1151278", "aliases": ["FAD-dependent glycerol-3-phosphate dehydrogenase", "L-glycerophosphate dehydrogenase activity", "glycerol-3-phosphate dehydrogenase (quinone) activity", "sn-glycerol-3-phosphate dehydrogenase activity", "flavin-linked glycerol-3-phosphate dehydrogenase", "glycerophosphate dehydrogenase activity", "sn-glycerol-3-phosphate:quinone oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. [EC:1.1.5.3]", "canonical_name": "glycerol-3-phosphate CoQ reductase"}
{"concept_id": "C1151279", "aliases": ["glycolate:(acceptor) 2-oxidoreductase activity", "glycolate oxidoreductase activity", "glycolic acid dehydrogenase activity", "glycolate:acceptor 2-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate. [EC:1.1.99.14, RHEA:21264]", "canonical_name": "glycolate dehydrogenase activity"}
{"concept_id": "C1151280", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene. [UM-BBD_reactionID:r0735]", "canonical_name": "limonene-1,2-diol dehydrogenase activity"}
{"concept_id": "C1151281", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule. [GOC:ai]"}
{"concept_id": "C1151283", "aliases": ["cholesterol- O2 oxidoreductase activity", "cholesterol:oxygen oxidoreductase activity", "cholesterol-O(2) oxidoreductase activity", "3beta-hydroxysteroid:oxygen oxidoreductase activity", "cholesterol oxidase activity", "cholesterol-O2 oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2. [RHEA:32183]", "canonical_name": "3beta-hydroxy steroid oxidoreductase activity"}
{"concept_id": "C1151284", "aliases": ["D-arabinono-1,4-lactone:oxygen oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+). [EC:1.1.3.37, RHEA:23756]", "canonical_name": "D-arabinono-1,4-lactone oxidase activity"}
{"concept_id": "C1151285", "aliases": ["D-galactose:oxygen 6-oxidoreductase activity", "D-galactose oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide. [EC:1.1.3.9]", "canonical_name": "galactose oxidase activity"}
{"concept_id": "C1151286", "aliases": ["beta-D-glucose:oxygen 1-oxidoreductase activity", "beta-D-glucose oxidase activity", "D-glucose-1-oxidase activity", "glucose aerodehydrogenase activity", "beta-D-glucose:quinone oxidoreductase activity", "beta-D-glucose:oxygen 1-oxido-reductase activity", "corylophyline", "D-glucose oxidase activity", "glucose oxidase activity", "glucose oxyhydrase activity", "GOD activity"], "types": ["T044"], "definition": "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2. [EC:1.1.3.4, GOC:mah]", "canonical_name": "penatin"}
{"concept_id": "C1151287", "aliases": ["L-alpha-glycerol-3-phosphate oxidase activity", "alpha-glycerophosphate oxidase activity", "glycerol phosphate oxidase activity", "L-alpha-glycerophosphate oxidase activity", "glycerol-1-phosphate oxidase activity", "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2). [EC:1.1.3.21, RHEA:18369]", "canonical_name": "glycerol-3-phosphate oxidase activity"}
{"concept_id": "C1151289", "aliases": ["long-chain-alcohol oxidase activity", "fatty alcohol oxidase activity", "long-chain-alcohol:oxygen oxidoreductase activity", "long-chain fatty acid oxidase activity", "fatty alcohol:oxygen oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O. [EC:1.1.3.20]", "canonical_name": "long-chain fatty alcohol oxidase activity"}
{"concept_id": "C1151291", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde. [MetaCyc:METHANOL-OXIDASE-RXN]", "canonical_name": "methanol oxidase activity"}
{"concept_id": "C1151292", "aliases": ["4-hydroxy-2-methoxybenzyl alcohol oxidase activity", "vanillyl-alcohol oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: O(2) + vanillyl alcohol = H(2)O(2) + vanillin. [EC:1.1.3.38, RHEA:10036]", "canonical_name": "vanillyl alcohol:oxygen oxidoreductase activity"}
{"concept_id": "C1151293", "aliases": ["xanthine oxidoreductase activity", "xanthine:O(2) oxidoreductase activity", "xanthine:oxygen oxidoreductase activity", "Schardinger enzyme activity", "hypoxanthine-xanthine oxidase activity", "xanthine oxidase activity", "xanthine:xanthine oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide. [EC:1.17.3.2]", "canonical_name": "xanthine:O2 oxidoreductase activity"}
{"concept_id": "C1151294", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151295", "aliases": [], "types": ["T044"], "canonical_name": "pinocarveol dehydrogenase activity", "definition": "Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-. [UM-BBD_reactionID:r0717]"}
{"concept_id": "C1151296", "aliases": [], "types": ["T044"], "canonical_name": "versicolorin reductase activity", "definition": "Catalysis of the reduction of versicolorin A to sterigmatocystin. [PMID:1339261]"}
{"concept_id": "C1151298", "aliases": ["ethylbenzene hydroxylase activity", "ethylbenzene:(acceptor) oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2). [EC:1.17.99.2, RHEA:17897]", "canonical_name": "ethylbenzene dehydrogenase activity"}
{"concept_id": "C1151299", "aliases": ["oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. [GOC:ai]"}
{"concept_id": "C1151300", "aliases": ["ribonucleoside 5'-diphosphate reductase activity", "ribonucleoside-diphosphate reductase activity", "ribonucleotide diphosphate reductase activity"], "types": ["T044"], "definition": "Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. [GOC:dph, GOC:vw, PMID:16756507]", "canonical_name": "RNR"}
{"concept_id": "C1151304", "aliases": ["2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity", "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin. [EC:1.17.4.2]", "canonical_name": "ribonucleoside-triphosphate reductase activity"}
{"concept_id": "C1151305", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. [GOC:ai]"}
{"concept_id": "C1151307", "aliases": ["p-cresol-(acceptor) oxidoreductase (hydroxylating) activity", "4-cresol dehydrogenase activity", "p-cresol methylhydroxylase activity", "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)"], "types": ["T044"], "canonical_name": "4-cresol dehydrogenase (hydroxylating) activity", "definition": "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor. [EC:1.17.9.1]"}
{"concept_id": "C1151308", "aliases": [], "types": ["T044"], "canonical_name": "p-cymene methyl hydroxylase activity", "definition": "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol. [RHEA:51604]"}
{"concept_id": "C1151309", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. [GOC:ai]"}
{"concept_id": "C1151310", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on diphenols and related substances as donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151312", "aliases": ["ubiquinol-cytochrome c-2 oxidoreductase activity", "cytochrome", "ubiquinone-cytochrome c oxidoreductase activity", "ubiquinone-cytochrome c reductase activity", "ubiquinol:ferricytochrome-c oxidoreductase activity", "ubiquinone--cytochrome-c oxidoreductase activity", "ubiquinol-cytochrome-c reductase activity", "ubiquinol-cytochrome c1 oxidoreductase activity", "ubiquinol-cytochrome c2 reductase activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. [RHEA:11484]", "canonical_name": "ubiquinol-cytochrome c oxidoreductase activity"}
{"concept_id": "C1151313", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]"}
{"concept_id": "C1151314", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen. [GOC:jl]"}
{"concept_id": "C1151315", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome b6f"}
{"concept_id": "C1151316", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]"}
{"concept_id": "C1151317", "aliases": [], "types": ["T044"], "definition": "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product. [ISBN:0943088399]", "canonical_name": "alternative oxidase activity"}
{"concept_id": "C1151318", "aliases": ["o-diphenolase activity", "catecholase", "polyphenol oxidase activity", "catechol oxidase activity", "o-diphenol oxidoreductase"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. [EC:1.10.3.1, PMID:22120533]", "canonical_name": "diphenol oxidase activity"}
{"concept_id": "C1151319", "aliases": ["L-ascorbate:oxygen oxidoreductase activity", "ascorbate dehydrogenase activity", "L-ascorbate:O2 oxidoreductase activity", "L-ascorbic acid oxidase activity", "AA oxidase activity", "ascorbic acid oxidase activity", "AAO", "ascorbic oxidase activity", "ascorbase activity", "ascorbate oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4 L-ascorbate + O(2) <=> 4 monodehydroascorbate + 2 H(2)O. [RHEA:30243]", "canonical_name": "L-ascorbate oxidase activity"}
{"concept_id": "C1151320", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. [EC:1.10.3.2]", "canonical_name": "laccase activity"}
{"concept_id": "C1151321", "aliases": ["oxidoreductase activity, acting on haem group of donors"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on a heme group of donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151322", "aliases": ["oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group. [GOC:jl]"}
{"concept_id": "C1151323", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on heme group of donors, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen. [GOC:jl]"}
{"concept_id": "C1151325", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on hydrogen as donor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor. [GOC:jl]"}
{"concept_id": "C1151326", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome. [GOC:jl]"}
{"concept_id": "C1151327", "aliases": ["oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein. [GOC:jl]"}
{"concept_id": "C1151328", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP. [GOC:jl]"}
{"concept_id": "C1151329", "aliases": ["chlorophyllide-a oxygenase activity", "CAO activity", "chlorophyllide a oxygenase activity", "chlorophyllide a:oxygen 7-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O. [EC:1.13.12.14, MetaCyc:RXN-7676]", "canonical_name": "chlorophyll a oxygenase activity"}
{"concept_id": "C1151330", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on hydrogen as donor, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound. [GOC:ai]"}
{"concept_id": "C1151331", "aliases": ["heterodisulfide reductase activity"], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate. [EC:1.12.99.2]", "canonical_name": "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity"}
{"concept_id": "C1151333", "aliases": ["oxidoreductase activity, acting on iron-sulphur proteins as donors"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on iron-sulfur proteins as donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151336", "aliases": ["carbonyl sulphide nitrogenase activity"], "types": ["T044"], "canonical_name": "carbonyl sulfide nitrogenase activity", "definition": "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide. [UM-BBD_reactionID:r0600]"}
{"concept_id": "C1151337", "aliases": ["nitrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. [PMID:15382920, RHEA:21448]", "canonical_name": "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity"}
{"concept_id": "C1151338", "aliases": [], "types": ["T044"], "canonical_name": "iron-iron nitrogenase activity", "definition": "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. [EC:1.18.6.1]"}
{"concept_id": "C1151339", "aliases": ["molybdenum-iron nitrogenase activity"], "types": ["T044"], "canonical_name": "molybdenum-iron nitrogenase activity", "definition": "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. [EC:1.18.6.1]"}
{"concept_id": "C1151340", "aliases": ["vanadium-iron nitrogenase activity"], "types": ["T044"], "canonical_name": "vanadium-iron nitrogenase activity", "definition": "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. [EC:1.18.6.1]"}
{"concept_id": "C1151343", "aliases": ["hydrogenase activity"], "types": ["T044"], "canonical_name": "hydrogenase activity"}
{"concept_id": "C1151344", "aliases": [], "types": ["T044"], "canonical_name": "iron hydrogenase activity"}
{"concept_id": "C1151346", "aliases": [], "types": ["T044"], "canonical_name": "nickel hydrogenase activity"}
{"concept_id": "C1151347", "aliases": ["Ni-Fe hydrogenase activity"], "types": ["T044"], "canonical_name": "nickel-iron hydrogenase activity"}
{"concept_id": "C1151348", "aliases": ["Ni-Fe-Se hydrogenase activity"], "types": ["T044"], "canonical_name": "nickel-iron-selenium hydrogenase activity"}
{"concept_id": "C1151350", "aliases": [], "types": ["T044"], "canonical_name": "ferredoxin reductase activity"}
{"concept_id": "C1151351", "aliases": ["NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)", "NADH2-ferredoxin oxidoreductase activity", "ferredoxin-nicotinamide adenine dinucleotide reductase activity", "ferredoxin:NAD+ oxidoreductase activity", "ferredoxin-NAD reductase activity", "NADH-ferredoxin oxidoreductase activity", "ferredoxin-NAD+ reductase activity", "NAD-ferredoxin reductase activity", "NADH flavodoxin oxidoreductase activity", "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin", "ferredoxin-linked NAD reductase activity", "NADH-ferredoxin reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+. [RHEA:16521]", "canonical_name": "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)"}
{"concept_id": "C1151352", "aliases": ["ferredoxin-NADP oxidoreductase activity", "ferredoxin-NADP reductase activity", "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity", "NADP:ferredoxin oxidoreductase activity", "ferredoxin-NADP-oxidoreductase activity", "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity", "ferredoxin-TPN reductase activity", "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity", "TPNH-ferredoxin reductase activity", "NADPH:ferredoxin oxidoreductase activity", "ferredoxin-NADP+ reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+. [GOC:kd, RHEA:20125]", "canonical_name": "ferredoxin:NADP+ oxidoreductase activity"}
{"concept_id": "C1151353", "aliases": ["NADPH:adrenodoxin oxidoreductase activity", "adrenodoxin-type ferredoxin reductase activity"], "types": ["T044"], "canonical_name": "NADPH-adrenodoxin reductase activity", "definition": "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+. [GOC:kd, RHEA:42312]"}
{"concept_id": "C1151355", "aliases": ["DPNH-rubredoxin reductase activity", "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity", "NADH--rubredoxin oxidoreductase activity", "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity", "NADH--rubredoxin reductase activity", "NADH:rubredoxin reductase activity", "NADH:rubredoxin oxidoreductase activity", "rubredoxin:NAD+ oxidoreductase activity", "rubredoxin--nicotinamide adenine dinucleotide reductase activity", "rubredoxin--NAD reductase activity"], "types": ["T044"], "canonical_name": "rubredoxin-NAD+ reductase activity", "definition": "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+. [RHEA:18597]"}
{"concept_id": "C1151356", "aliases": ["rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity", "NAD(P)H--rubredoxin oxidoreductase activity", "rubredoxin:NAD(P)+ oxidoreductase activity", "NAD(P)--rubredoxin oxidoreductase activity", "NADPH:rubredoxin reductase activity"], "types": ["T044"], "canonical_name": "rubredoxin-NAD(P)+ reductase activity", "definition": "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+. [EC:1.18.1.4]"}
{"concept_id": "C1151357", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NADH or NADPH"}
{"concept_id": "C1151358", "aliases": [], "types": ["T044"], "definition": "Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+. [PMID:9555888]", "canonical_name": "epoxide carboxylase activity"}
{"concept_id": "C1151360", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol. [UM-BBD_reactionID:r0684]", "canonical_name": "alkyl hydroperoxide reductase activity"}
{"concept_id": "C1151361", "aliases": ["NADPH:trypanothione oxidoreductase activity", "trypanothione-disulphide reductase activity", "N(1),N(8)-bis(glutathionyl)spermidine reductase activity", "N1,N8-bis(glutathionyl)spermidine reductase activity", "trypanothione:NADP+ oxidoreductase activity", "trypanothione-disulfide reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide. [RHEA:16757]", "canonical_name": "trypanothione reductase activity"}
{"concept_id": "C1151363", "aliases": ["oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor", "oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. [GOC:ai]"}
{"concept_id": "C1151365", "aliases": ["cytochrome-b5 reductase activity", "NADH-cytochrome-b5 reductase activity", "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity", "NADH 5alpha-reductase activity", "cytochrome-b5 reductase activity, acting on NAD(P)H", "cytochrome b5 reductase activity", "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity", "NADH:ferricytochrome-b5 oxidoreductase activity", "NADH-ferricytochrome b5 oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5). [EC:1.6.2.2, ISBN:0198547684]", "canonical_name": "NADH-cytochrome b5 reductase activity"}
{"concept_id": "C1151366", "aliases": ["NAD(P)H:ferrileghemoglobin oxidoreductase activity", "ferric leghemoglobin reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin. [EC:1.6.2.6]", "canonical_name": "leghemoglobin reductase activity"}
{"concept_id": "C1151367", "aliases": ["energy-linked transhydrogenase"], "types": ["T044"], "definition": "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. [EC:1.6.1.1, EC:1.6.1.2]", "canonical_name": "NAD(P)+ transhydrogenase activity"}
{"concept_id": "C1151368", "aliases": ["NADPH:NAD+ oxidoreductase (AB-specific)", "NAD(P) transhydrogenase (AB-specific) activity"], "types": ["T044"], "canonical_name": "NAD(P)+ transhydrogenase (AB-specific) activity", "definition": "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf]"}
{"concept_id": "C1151369", "aliases": ["non-energy-linked transhydrogenase activity", "NAD(P)+ transhydrogenase (B-specific) activity", "NAD(P) transhydrogenase (B-specific) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+. [EC:1.6.1.1]", "canonical_name": "NADPH:NAD+ oxidoreductase (B-specific)"}
{"concept_id": "C1151370", "aliases": ["NADPH:P-450 reductase activity", "NADPH:cytochrome c reductase activity", "NADPH-ferrihemoprotein reductase activity", "NADPH:hemoprotein oxidoreductase activity", "NADPH:P450 reductase activity", "NADPH:ferrihemoprotein oxidoreductase activity", "NADPH-cytochrome p-450 reductase activity", "NADPH--cytochrome c reductase activity", "NADPH--cytochrome P450 reductase activity", "NADPH:cytochrome P450 reductase activity", "cytochrome P-450 reductase activity", "POR", "NADPH--ferrihemoprotein reductase activity", "cytochrome P450 reductase activity", "NADPH-cytochrome P-450 oxidoreductase activity", "NADPH-hemoprotein reductase activity", "NADPH--cytochrome P450 oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. [EC:1.6.2.4]", "canonical_name": "TPNH2 cytochrome c reductase activity"}
{"concept_id": "C1151371", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor"}
{"concept_id": "C1151372", "aliases": [], "types": ["T044"], "canonical_name": "4-amino-2-nitroso-6-nitrotoluene reductase activity", "definition": "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene. [UM-BBD_reactionID:r0464]"}
{"concept_id": "C1151373", "aliases": ["4-carboxy-4'-sulphoazobenzene reductase activity"], "types": ["T044"], "canonical_name": "4-carboxy-4'-sulfoazobenzene reductase activity", "definition": "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate. [UM-BBD_reactionID:r0543]"}
{"concept_id": "C1151374", "aliases": ["inosine-5'-phosphate:NADP+ oxidoreductase (aminating)", "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)", "guanosine 5'-monophosphate oxidoreductase activity", "NADPH:GMP oxidoreductase (deaminating) activity", "guanosine 5'-monophosphate reductase activity", "guanosine 5'-phosphate reductase activity", "guanosine monophosphate reductase activity", "GMP reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH. [EC:1.7.1.7, RHEA:17185]", "canonical_name": "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity"}
{"concept_id": "C1151375", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)H nitroreductase activity", "definition": "Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative. [UM-BBD_enzymeID:e0346]"}
{"concept_id": "C1151376", "aliases": ["assimilatory NADH: nitrate reductase activity", "nitrate reductase (NADH2)", "NADH:nitrate oxidoreductase activity", "NADH-nitrate reductase activity", "nitrate reductase (NADH) activity", "NADH:nitrate reductase activity", "nitrite:NAD+ oxidoreductase activity", "nitrate reductase (NADH(2)) activity", "assimilatory NADH:nitrate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+. [EC:1.7.1.1]", "canonical_name": "NADH-dependent nitrate reductase activity"}
{"concept_id": "C1151378", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O. [MetaCyc:RXN-8815]", "canonical_name": "nitrobenzene nitroreductase activity"}
{"concept_id": "C1151379", "aliases": ["trimethylamine oxidase activity", "trimethylamine oxide reductase", "trimethylamine-N-oxide reductase activity", "NADH:trimethylamine-N-oxide oxidoreductase"], "types": ["T044"], "definition": "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O. [RHEA:22024]", "canonical_name": "trimethylamine N-oxide reductase"}
{"concept_id": "C1151380", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NADH or NADPH, other acceptor", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen. [GOC:jl]"}
{"concept_id": "C1151381", "aliases": ["dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity", "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity", "dihydropteridine reductase activity", "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity", "NADPH-specific dihydropteridine reductase activity", "6,7-dihydropteridine:NAD(P)H oxidoreductase activity", "NADH-dihydropteridine reductase activity", "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity", "NADPH-dihydropteridine reductase activity", "6,7-dihydropteridine reductase activity", "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity", "dihydropteridine reductase (NADH) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. [EC:1.5.1.34]", "canonical_name": "DHPR activity"}
{"concept_id": "C1151382", "aliases": ["ferric chelate reductase activity", "iron chelate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor. [PMID:33559753]", "canonical_name": "ferric-chelate reductase activity"}
{"concept_id": "C1151383", "aliases": ["NAD(P)H-quinone dehydrogenase activity", "NADPH diaphorase activity", "OYE", "TPNH-diaphorase activity", "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity", "NAD(P)H dehydrogenase activity", "nitric-oxide synthetase activity", "NAD(P)H-quinone oxidoreductase activity", "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity", "triphosphopyridine nucleotide diaphorase activity", "flavoprotein NAD(P)H-quinone reductase activity", "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity", "TPNH dehydrogenase activity", "NAD(P)H dehydrogenase (quinone) activity", "DT-diaphorase activity", "NQO1", "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity", "QR1", "nitric oxide synthetase activity", "NO synthase activity", "NAD(P)H dehydrogenase", "nitric oxide synthase activity", "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity", "quinone reductase activity", "NADPH:(acceptor) oxidoreductase activity", "NADPH dehydrogenase activity", "NAD(P)H(2) dehydrogenase (quinone) activity", "NADPH-dehydrogenase activity", "naphthoquinone reductase activity", "NAD(P)H:quinone oxidoreductase activity", "reduced NAD(P)H dehydrogenase activity", "NADPH-diaphorase activity", "nitric-oxide synthase activity", "NADPH2 diaphorase activity", "NADPH:acceptor oxidoreductase activity", "NAD(P)H:(quinone-acceptor)oxidoreductase activity", "NAD(P)H2 dehydrogenase (quinone)", "triphosphopyridine diaphorase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor. [RHEA:13149]", "canonical_name": "NADPH2-dehydrogenase activity"}
{"concept_id": "C1151384", "aliases": ["DPNH diaphorase activity", "NADH:(acceptor) oxidoreductase activity", "diphosphopyridine diaphorase activity", "beta-NADH dehydrogenase dinucleotide activity", "NADH oxidoreductase activity", "reduced diphosphopyridine nucleotide diaphorase activity", "dihydronicotinamide adenine dinucleotide dehydrogenase activity", "NADH2 dehydrogenase activity", "diphosphopyrinase activity", "dihydrocodehydrogenase I dehydrogenase activity", "NADH dehydrogenase activity", "NADH:acceptor oxidoreductase activity", "NADH hydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. [RHEA:11356]", "canonical_name": "NADH diaphorase activity"}
{"concept_id": "C1151386", "aliases": ["reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase", "NADPH dehydrogenase (quinone) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol. [EC:1.6.5.10]", "canonical_name": "NADPH:(quinone-acceptor) oxidoreductase"}
{"concept_id": "C1151387", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor"}
{"concept_id": "C1151389", "aliases": ["monodehydroascorbate reductase activity", "AFR-reductase activity", "NADH-semidehydroascorbate oxidoreductase activity", "MDHA", "NADH:AFR oxidoreductase activity", "MDAsA reductase (NADPH)", "semidehydroascorbate reductase activity", "ascorbate free radical reductase activity", "NADH:monodehydroascorbate oxidoreductase activity", "monodehydroascorbate reductase (NADH) activity", "SDA reductase activity", "ascorbic free radical reductase activity", "NADH:ascorbate radical oxidoreductase activity", "ascorbate free-radical reductase activity", "NADH:semidehydroascorbic acid oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate. [EC:1.6.5.4]", "canonical_name": "AFR"}
{"concept_id": "C1151390", "aliases": ["NADH-ubiquinone reductase activity", "NADH-CoQ reductase activity", "NADH:ubiquinone oxidoreductase activity", "NADH-ubiquinone oxidoreductase activity", "NADH dehydrogenase (ubiquinone) activity", "NADH-coenzyme Q reductase activity", "ubiquinone reductase activity", "DPNH-ubiquinone reductase activity", "NADH-coenzyme Q oxidoreductase activity", "NADH-CoQ oxidoreductase activity", "NADH-ubiquinone-1 reductase activity", "NADH coenzyme Q1 reductase activity", "NADH-Q6 oxidoreductase activity", "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity", "coenzyme Q reductase activity", "DPNH-coenzyme Q reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out). [RHEA:29091]", "canonical_name": "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity"}
{"concept_id": "C1151392", "aliases": ["NADPH:quinone reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. [EC:1.6.5.5]", "canonical_name": "NADPH:quinone oxidoreductase activity"}
{"concept_id": "C1151393", "aliases": ["NADPH:p-benzoquinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "p-benzoquinone reductase (NADPH) activity", "definition": "Catalysis of the reaction: 1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+). [EC:1.6.5.6, RHEA:23488]"}
{"concept_id": "C1151394", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on other nitrogenous compounds as donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151395", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome. [GOC:jl]"}
{"concept_id": "C1151396", "aliases": ["ammonia:ferricytochrome-c oxidoreductase activity", "multiheme nitrite reductase activity", "nitrite reductase (cytochrome, ammonia-forming) activity", "nitrite reductase (cytochrome; ammonia-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+. [EC:1.7.2.2]", "canonical_name": "cytochrome c nitrite reductase activity"}
{"concept_id": "C1151397", "aliases": ["oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:jl]"}
{"concept_id": "C1151398", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP. [GOC:jl]"}
{"concept_id": "C1151400", "aliases": ["nitrite:acceptor oxidoreductase", "nitrate reductase activity", "nitrite:(acceptor) oxidoreductase"], "types": ["T044"], "definition": "Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. [EC:1.7.99.4]", "canonical_name": "nitrate reductase (acceptor)"}
{"concept_id": "C1151401", "aliases": ["nitrous-oxide:(acceptor) oxidoreductase (NO-forming)", "nitric-oxide reductase activity", "CYP55", "nitric oxide reductase activity", "nitrous-oxide:acceptor oxidoreductase (NO-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + 2 ferricytochrome c + nitrous oxide = 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide. [EC:1.7.2.5]", "canonical_name": "nitrogen oxide reductase activity"}
{"concept_id": "C1151404", "aliases": [], "types": ["T044"], "canonical_name": "pentaerythritol tetranitrate reductase activity"}
{"concept_id": "C1151405", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]"}
{"concept_id": "C1151406", "aliases": ["nitroglycerin reductase activity"], "types": ["T044"], "definition": "Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative. [UM-BBD_enzymeID:e0038]", "canonical_name": "NG reductase activity"}
{"concept_id": "C1151407", "aliases": ["urate:oxygen oxidoreductase activity", "uric acid oxidase activity", "uricase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide. [EC:1.7.3.3]", "canonical_name": "urate oxidase activity"}
{"concept_id": "C1151408", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on other substrates", "definition": "OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized. [GOC:ai]"}
{"concept_id": "C1151409", "aliases": ["1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity", "DDE dehalogenase activity"], "types": ["T044"], "canonical_name": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity", "definition": "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. [UM-BBD_reactionID:r0440]"}
{"concept_id": "C1151410", "aliases": ["1,2-dichloroethylene reductive dehalogenase activity"], "types": ["T044"], "canonical_name": "1,2-dichloroethene reductive dehalogenase activity", "definition": "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride. [UM-BBD_enzymeID:e0272]"}
{"concept_id": "C1151411", "aliases": [], "types": ["T044"], "canonical_name": "2,4-dichlorophenoxyacetate dehalogenase activity", "definition": "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate. [UM-BBD_reactionID:r0280]"}
{"concept_id": "C1151412", "aliases": [], "types": ["T044"], "canonical_name": "2,5-dichlorohydroquinone reductive dehalogenase activity", "definition": "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone). [UM-BBD_enzymeID:e0366]"}
{"concept_id": "C1151413", "aliases": [], "types": ["T044"], "canonical_name": "2-chloro-N-isopropylacetanilide reductive dehalogenase activity", "definition": "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide. [UM-BBD_reactionID:r0719]"}
{"concept_id": "C1151416", "aliases": ["pyrogallol hydroxytransferase activity", "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)", "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity", "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity", "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity", "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene. [EC:1.97.1.2]", "canonical_name": "pyrogallol hydroxyltransferase activity"}
{"concept_id": "C1151417", "aliases": [], "types": ["T044"], "canonical_name": "ribonucleotide reductase activating enzyme activity"}
{"concept_id": "C1151419", "aliases": [], "types": ["T044"], "canonical_name": "vinyl chloride reductive dehalogenase activity", "definition": "Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene. [UM-BBD_reactionID:r0352]"}
{"concept_id": "C1151420", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. [GOC:mah]"}
{"concept_id": "C1151421", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyisobutyrate 3-monooxygenase activity", "definition": "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate. [UM-BBD_reactionID:r0619]"}
{"concept_id": "C1151422", "aliases": [], "types": ["T044"], "canonical_name": "2-octaprenyl-6-methoxyphenol hydroxylase activity", "definition": "Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O. [PMID:27822549, PMID:4572721, RHEA:29407]"}
{"concept_id": "C1151423", "aliases": [], "types": ["T044"], "canonical_name": "4-chlorophenoxyacetate monooxygenase activity", "definition": "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol. [UM-BBD_reactionID:r0281]"}
{"concept_id": "C1151424", "aliases": [], "types": ["T044"], "canonical_name": "4-nitrocatechol 4-monooxygenase activity", "definition": "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol. [UM-BBD_reactionID:r0231]"}
{"concept_id": "C1151425", "aliases": ["4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)", "4-nitrophenol-2-hydroxylase activity", "4-nitrophenol 2-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+). [EC:1.14.13.29, RHEA:12568]", "canonical_name": "4-nitrophenol hydroxylase activity"}
{"concept_id": "C1151426", "aliases": [], "types": ["T044"], "canonical_name": "alpha-pinene dehydrogenase activity", "definition": "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol. [UM-BBD_reactionID:r0709]"}
{"concept_id": "C1151427", "aliases": [], "types": ["T044"], "canonical_name": "alpha-pinene monooxygenase activity", "definition": "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol. [UM-BBD_reactionID:r0716]"}
{"concept_id": "C1151428", "aliases": [], "types": ["T044"], "definition": "Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions. [PMID:16347810]", "canonical_name": "ammonia monooxygenase activity"}
{"concept_id": "C1151429", "aliases": ["DBT dioxygenase activity"], "types": ["T044"], "canonical_name": "di-n-butyltin dioxygenase activity", "definition": "Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin. [UM-BBD_reactionID:r0645]"}
{"concept_id": "C1151430", "aliases": ["DMSD hydroxylase activity"], "types": ["T044"], "canonical_name": "dimethylsilanediol hydroxylase activity", "definition": "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol. [UM-BBD_reactionID:r0637]"}
{"concept_id": "C1151431", "aliases": [], "types": ["T044"], "canonical_name": "fluorene oxygenase activity", "definition": "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol. [UM-BBD_reactionID:r0407]"}
{"concept_id": "C1151432", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethylsilanetriol oxidase activity", "definition": "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol. [UM-BBD_reactionID:r0641]"}
{"concept_id": "C1151433", "aliases": ["MTBE 3-monooxygenase activity"], "types": ["T044"], "canonical_name": "methyl tertiary butyl ether 3-monooxygenase activity", "definition": "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde. [UM-BBD_reactionID:r1023]"}
{"concept_id": "C1151434", "aliases": [], "types": ["T044"], "canonical_name": "methylsilanetriol hydroxylase activity", "definition": "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol. [UM-BBD_reactionID:r0640]"}
{"concept_id": "C1151435", "aliases": ["MBT dioxygenase activity"], "types": ["T044"], "canonical_name": "mono-butyltin dioxygenase activity", "definition": "Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin. [UM-BBD_reactionID:r0647]"}
{"concept_id": "C1151436", "aliases": ["oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors", "2-oxoglutarate dioxygenase activity"], "types": ["T044"], "canonical_name": "2-oxoglutarate-dependent dioxygenase activity", "definition": "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. [GOC:mah]"}
{"concept_id": "C1151437", "aliases": ["DACS", "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity", "3'-methylcephem hydroxylase activity", "deacetylcephalosporin C synthase activity", "beta-lactam hydroxylase activity", "DAOC hydroxylase activity", "deacetoxycephalosporin-C hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O(2) = CO(2) + deacetylcephalosporin C + succinate. [EC:1.14.11.26, RHEA:16805]", "canonical_name": "deacetoxycephalosporin C hydroxylase activity"}
{"concept_id": "C1151438", "aliases": ["alpha-butyrobetaine hydroxylase activity", "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)", "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity", "butyrobetaine hydroxylase activity", "gamma-butyrobetaine hydroxylase activity", "g-butyrobetaine dioxygenase activity", "gamma-butyrobetaine dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate. [EC:1.14.11.1, RHEA:24028]", "canonical_name": "gamma-BBH activity"}
{"concept_id": "C1151439", "aliases": ["gibberellin 2-oxidase activity", "gibberellin 2beta-hydroxylase activity", "gibberellin 2-beta-hydroxylase activity", "gibberellin 2-beta-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2. [EC:1.14.11.13, GOC:kad]", "canonical_name": "gibberellin 2beta-dioxygenase activity"}
{"concept_id": "C1151440", "aliases": [], "types": ["T044"], "definition": "Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones. [PMID:7604047]", "canonical_name": "gibberellin 20-oxidase activity"}
{"concept_id": "C1151441", "aliases": ["gibberellin 3beta-hydroxylase activity", "gibberellin 3-beta-dioxygenase activity", "gibberellin 3beta-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2. [EC:1.14.11.15, GOC:kad]", "canonical_name": "gibberellin 3-beta-hydroxylase activity"}
{"concept_id": "C1151442", "aliases": ["flavanone 3-hydroxylase activity", "naringenin 3-hydroxylase activity", "(2S)-flavanone 3-hydroxylase activity", "flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)", "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity", "naringenin 3-dioxygenase activity", "flavanone synthase I activity", "flavanone 3beta-hydroxylase activity", "flavanone 3-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2. [EC:1.14.11.9]", "canonical_name": "flavanone 3-beta-hydroxylase activity"}
{"concept_id": "C1151444", "aliases": ["lysylprotocollagen dioxygenase activity", "procollagen-lysine 5-dioxygenase activity", "lysine hydroxylase activity", "lysine,2-oxoglutarate 5-dioxygenase activity", "protocollagen lysyl hydroxylase activity", "collagen lysine hydroxylase activity", "protocollagen lysine hydroxylase activity", "protocollagen lysine dioxygenase activity", "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)", "lysine-2-oxoglutarate dioxygenase activity", "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. [EC:1.14.11.4]", "canonical_name": "lysyl hydroxylase activity"}
{"concept_id": "C1151445", "aliases": ["collagen proline hydroxylase activity", "procollagen-proline,2-oxoglutarate-4-dioxygenase activity", "peptidyl-proline 4-dioxygenase activity", "prolylprotocollagen hydroxylase activity", "prolylprotocollagen dioxygenase activity", "procollagen-proline 4-dioxygenase activity", "proline protocollagen hydroxylase activity", "hydroxylase, collagen proline activity", "protocollagen prolyl hydroxylase activity", "protocollagen proline dioxygenase activity", "protocollagen proline 4-hydroxylase activity", "procollagen-proline dioxygenase activity", "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2. [GOC:mah, PMID:4371784]", "canonical_name": "protocollagen proline hydroxylase activity"}
{"concept_id": "C1151446", "aliases": ["procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity", "proline,2-oxoglutarate 3-dioxygenase activity", "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity", "protocollagen proline 3-hydroxylase activity", "procollagen-proline,2-oxoglutarate 3-dioxygenase activity"], "types": ["T044"], "canonical_name": "procollagen-proline 3-dioxygenase activity", "definition": "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. [EC:1.14.11.7, RHEA:22872]"}
{"concept_id": "C1151448", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor. [GOC:mah]"}
{"concept_id": "C1151449", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous", "definition": "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized. [GOC:ai]"}
{"concept_id": "C1151450", "aliases": ["4-methoxybenzoate monooxygenase activity", "4-methoxybenzoate O-demethylase activity", "4-methoxybenzoate 4-monooxygenase (O-demethylating)", "piperonylate-4-O-demethylase activity", "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)", "p-anisic O-demethylase activity"], "types": ["T044"], "canonical_name": "4-methoxybenzoate monooxygenase (O-demethylating) activity", "definition": "Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O. [EC:1.14.99.15, RHEA:18613]"}
{"concept_id": "C1151451", "aliases": ["stearyl-ACP desaturase activity", "acyl-[acyl-carrier-protein] desaturase activity", "acyl-acyl-carrier-protein desaturase activity", "acyl-[acyl-carrier protein] desaturase activity", "stearyl acyl carrier protein desaturase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. [EC:1.14.19.2]", "canonical_name": "acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity"}
{"concept_id": "C1151452", "aliases": ["zeta-carotene desaturase activity", "carotene 7,8-desaturase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O. [RHEA:30955]", "canonical_name": "carotene,hydrogen-donor:oxygen oxidoreductase activity"}
{"concept_id": "C1151453", "aliases": [], "types": ["T044"], "canonical_name": "CoA desaturase activity"}
{"concept_id": "C1151454", "aliases": ["acyl-CoA delta(11)-desaturase activity", "acyl-CoA D11-desaturase activity"], "types": ["T044"], "canonical_name": "acyl-CoA delta11-desaturase activity", "definition": "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta11-acyl-CoA + acceptor + 2 H2O. The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. [EC:1.14.19.5]"}
{"concept_id": "C1151455", "aliases": ["linoleoyl CoA desaturase activity", "delta6-desaturase activity", "fatty acid delta6-desaturase activity", "linoleoyl-coenzyme A desaturase activity", "delta6-acyl CoA desaturase activity", "linoleoyl-CoA desaturase activity", "long-chain fatty acid delta6-desaturase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O. [PMID:12713571, PMID:7212717, RHEA:47140]", "canonical_name": "delta6-fatty acyl-CoA desaturase activity"}
{"concept_id": "C1151457", "aliases": ["linoleate delta12-fatty acid acetylenase (desaturase)", "delta12 fatty acid acetylenase activity", "delta-12 fatty acid acetylenase activity", "D12-fatty acid dehydrogenase activity", "linoleate delta-12-fatty acid acetylenase (desaturase) activity", "linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)"], "types": ["T044"], "canonical_name": "delta12-fatty acid dehydrogenase activity", "definition": "Catalysis of the reaction: AH(2) + linoleate + O(2) = A + crepenynate + 2 H(2)O. [EC:1.14.99.33, RHEA:23456]"}
{"concept_id": "C1151458", "aliases": [], "types": ["T044"], "canonical_name": "DDT 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT. [UM-BBD_reactionID:r0450]"}
{"concept_id": "C1151459", "aliases": ["deoxyhypusine dioxygenase activity", "deoxyhypusine hydroxylase activity", "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)", "deoxyhypusine monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O. [EC:1.14.99.29]", "canonical_name": "DOHH activity"}
{"concept_id": "C1151460", "aliases": ["haem oxygenase activity", "heme oxidase activity", "heme oxygenase activity", "haem oxidase activity", "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)", "heme oxygenase (decyclizing) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]. [RHEA:21764]", "canonical_name": "haem oxygenase (decyclizing) activity"}
{"concept_id": "C1151461", "aliases": ["naphthalene disulphonate 1,2-dioxygenase activity"], "types": ["T044"], "canonical_name": "naphthalene disulfonate 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene). [UM-BBD_enzymeID:e0249]"}
{"concept_id": "C1151462", "aliases": [], "types": ["T044"], "definition": "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain. [GOC:jl, PMID:9037020]", "canonical_name": "omega-3 fatty acid desaturase activity"}
{"concept_id": "C1151463", "aliases": [], "types": ["T044"], "canonical_name": "omega-6 fatty acid desaturase activity", "definition": "Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain. [PMID:7846158]"}
{"concept_id": "C1151464", "aliases": ["fatty acid cyclooxygenase activity", "prostaglandin synthase activity", "PG synthetase activity", "prostaglandin endoperoxide synthetase activity", "(PG)H synthase activity", "prostaglandin synthetase activity", "prostaglandin-endoperoxide synthase activity", "prostaglandin G/H synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. [EC:1.14.99.1]", "canonical_name": "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity"}
{"concept_id": "C1151466", "aliases": [], "types": ["T044"], "canonical_name": "3-(3-hydroxyphenyl)propionate hydroxylase activity", "definition": "Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O. [RHEA:24785]"}
{"concept_id": "C1151467", "aliases": [], "types": ["T044"], "canonical_name": "4-chlorobenzaldehyde oxidase activity", "definition": "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-. [UM-BBD_reactionID:r0447]"}
{"concept_id": "C1151468", "aliases": ["flavonoid 3'-monooxygenase activity", "flavonoid 3'-hydroxylase activity", "NADPH:flavonoid-3'-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O. [EC:1.14.14.82]", "canonical_name": "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)"}
{"concept_id": "C1151469", "aliases": [], "types": ["T044"], "definition": "Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene. [GOC:mah, PMID:820855]", "canonical_name": "limonene monooxygenase activity"}
{"concept_id": "C1151472", "aliases": ["trans-cinnamate 4-hydroxylase activity", "hydroxylase, cinnamate 4-", "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)", "trans-cinnamate 4-monooxygenase activity", "cinnamic acid 4-hydroxylase activity", "cinnamate 4-monooxygenase activity", "cinnamate hydroxylase activity", "oxygenase, cinnamate 4-mono-", "cytochrome P450 cinnamate 4-hydroxylase activity", "trans-cinnamic acid 4-hydroxylase activity", "cinnamic 4-hydroxylase activity", "cinnamate 4-hydroxylase activity", "t-cinnamic acid hydroxylase activity", "cinnamic acid p-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O. [EC:1.14.14.91]", "canonical_name": "cinnamic acid 4-monooxygenase activity"}
{"concept_id": "C1151474", "aliases": [], "types": ["T044"], "canonical_name": "1-indanone dioxygenase activity", "definition": "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone. [UM-BBD_reactionID:r0416]"}
{"concept_id": "C1151475", "aliases": [], "types": ["T044"], "canonical_name": "1-indanone monooxygenase activity", "definition": "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin. [UM-BBD_reactionID:r0417]"}
{"concept_id": "C1151476", "aliases": ["2-aminobenzenesulphonate dioxygenase activity", "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)", "2-aminobenzenesulfonate 2,3-dioxygenase activity", "2-aminobenzenesulfonate dioxygenase activity", "2-aminobenzenesulphonate 2,3-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol. [EC:1.14.12.14, RHEA:23468]", "canonical_name": "2-aminosulfobenzene 2,3-dioxygenase activity"}
{"concept_id": "C1151478", "aliases": ["2-halobenzoate 1,2-dioxygenase activity", "2-chlorobenzoate 1,2-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2. [EC:1.14.12.13]", "canonical_name": "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)"}
{"concept_id": "C1151479", "aliases": [], "types": ["T044"], "canonical_name": "2-indanone monooxygenase activity", "definition": "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone. [UM-BBD_reactionID:r0424]"}
{"concept_id": "C1151480", "aliases": ["quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)", "2-hydroxyquinoline 5,6-dioxygenase activity", "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity", "quinolin-2-ol 5,6-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+. [EC:1.14.12.16]", "canonical_name": "quinolin-2(1H)-one 5,6-dioxygenase activity"}
{"concept_id": "C1151481", "aliases": ["3-phenylpropionate dioxygenase activity", "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity", "3-phenylpropanoate dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol. [UM-BBD_enzymeID:e0307]", "canonical_name": "Hca dioxygenase activity"}
{"concept_id": "C1151482", "aliases": ["4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity"], "types": ["T044"], "canonical_name": "4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity", "definition": "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol. [UM-BBD_reactionID:r0580]"}
{"concept_id": "C1151483", "aliases": [], "types": ["T044"], "canonical_name": "4-aminobenzoate 3,4-dioxygenase (deaminating) activity", "definition": "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate. [UM-BBD_reactionID:r0566]"}
{"concept_id": "C1151484", "aliases": ["4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-chlorophenylacetate + NADH + O(2) = 3,4-dihydroxyphenylacetate + chloride + NAD(+). [EC:1.14.12.9, RHEA:14689]", "canonical_name": "4-chlorophenylacetate 3,4-dioxygenase activity"}
{"concept_id": "C1151485", "aliases": ["4-sulphobenzoate 3,4-dioxygenase activity", "4-sulfobenzoate dioxygenase activity", "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-sulfobenzoate + H(+) + NADH + O(2) = 3,4-dihydroxybenzoate + NAD(+) + sulfite. [EC:1.14.12.8, RHEA:13937]", "canonical_name": "4-sulfobenzoate 3,4-dioxygenase activity"}
{"concept_id": "C1151486", "aliases": [], "types": ["T044"], "canonical_name": "9-fluorenone dioxygenase activity", "definition": "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone. [UM-BBD_reactionID:r0409]"}
{"concept_id": "C1151487", "aliases": ["anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity", "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)", "AntA", "anthranilate dioxygenase activity", "AntB"], "types": ["T044"], "definition": "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3. [EC:1.14.12.1]", "canonical_name": "AntC"}
{"concept_id": "C1151488", "aliases": ["benzene 1,2-dioxygenase activity", "benzene dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: benzene + H(+) + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+). [EC:1.14.12.3, RHEA:13813]", "canonical_name": "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)"}
{"concept_id": "C1151489", "aliases": ["benzenesulphonate dioxygenase activity"], "types": ["T044"], "canonical_name": "benzenesulfonate dioxygenase activity", "definition": "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol. [UM-BBD_reactionID:r0295]"}
{"concept_id": "C1151490", "aliases": ["benzoate 1,2-dioxygenase activity", "benzoate hydroxylase activity", "benzoic hydroxylase activity", "benzoate dioxygenase activity", "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+. [EC:1.14.12.10]", "canonical_name": "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)"}
{"concept_id": "C1151491", "aliases": ["biphenyl dioxygenase activity", "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)"], "types": ["T044"], "canonical_name": "biphenyl 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+. [EC:1.14.12.18]"}
{"concept_id": "C1151492", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene). [UM-BBD_enzymeID:e0062]", "canonical_name": "chlorobenzene dioxygenase activity"}
{"concept_id": "C1151493", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+. [MetaCyc:R606-RXN, RHEA:42460]", "canonical_name": "dibenzofuran 4,4a-dioxygenase activity"}
{"concept_id": "C1151494", "aliases": [], "types": ["T044"], "canonical_name": "dibenzothiophene dioxygenase activity", "definition": "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene. [UM-BBD_reactionID:r0160]"}
{"concept_id": "C1151495", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene. [UM-BBD_reactionID:r0247]", "canonical_name": "ethylbenzene dioxygenase activity"}
{"concept_id": "C1151496", "aliases": ["naphthalene 1,2-dioxygenase activity", "naphthalene oxygenase activity", "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+. [EC:1.14.12.12]", "canonical_name": "naphthalene dioxygenase activity"}
{"concept_id": "C1151497", "aliases": ["nitric oxide dioxygenase activity", "nitric oxide,NAD(P)H:oxygen oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+. [EC:1.14.12.17]", "canonical_name": "NOD activity"}
{"concept_id": "C1151498", "aliases": [], "types": ["T044"], "canonical_name": "nitrobenzene 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol. [UM-BBD_reactionID:r0306]"}
{"concept_id": "C1151499", "aliases": ["phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)", "phthalate 4,5-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + NADH + O(2) + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+). [EC:1.14.12.7, RHEA:17489]", "canonical_name": "PDO activity"}
{"concept_id": "C1151500", "aliases": ["benzene-1,4-dicarboxylate 1,2-dioxygenase activity", "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)", "terephthalate 1,2-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + NADH + O(2) + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+). [EC:1.14.12.15, RHEA:10312]", "canonical_name": "1,4-dicarboxybenzoate 1,2-dioxygenase activity"}
{"concept_id": "C1151501", "aliases": [], "types": ["T044"], "canonical_name": "toluate dioxygenase activity", "definition": "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate. [UM-BBD_enzymeID:e0190]"}
{"concept_id": "C1151502", "aliases": ["toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)", "toluene 1,2-dioxygenase activity", "toluene 2,3-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+). [EC:1.14.12.11, RHEA:16737]", "canonical_name": "toluene dioxygenase activity"}
{"concept_id": "C1151503", "aliases": [], "types": ["T044"], "canonical_name": "trihydroxytoluene dioxygenase activity", "definition": "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate. [PMID:1254564, UM-BBD_reactionID:r0093]"}
{"concept_id": "C1151504", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]"}
{"concept_id": "C1151505", "aliases": ["flavoprotein-linked monooxygenase activity", "flavoprotein monooxygenase activity", "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]"}
{"concept_id": "C1151506", "aliases": ["oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]"}
{"concept_id": "C1151507", "aliases": ["choline monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O. [EC:1.14.15.7]", "canonical_name": "choline,reduced-ferredoxin:oxygen oxidoreductase activity"}
{"concept_id": "C1151508", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]"}
{"concept_id": "C1151509", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. [GOC:mah]"}
{"concept_id": "C1151510", "aliases": ["tert-butyl alcohol 2-monooxygenase activity"], "types": ["T044"], "canonical_name": "tert-butanol 2-monooxygenase activity", "definition": "Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol. [UM-BBD_reactionID:r0615]"}
{"concept_id": "C1151511", "aliases": ["TBT dioxygenase activity"], "types": ["T044"], "canonical_name": "tri-n-butyltin dioxygenase activity", "definition": "Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin. [UM-BBD_reactionID:r0643]"}
{"concept_id": "C1151512", "aliases": ["zeaxanthin epoxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]. [RHEA:32443]", "canonical_name": "zea-epoxidase activity"}
{"concept_id": "C1151513", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on peroxide as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151514", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]", "canonical_name": "bacterial catalase-peroxidase activity"}
{"concept_id": "C1151515", "aliases": ["optidase activity", "equilase activity", "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity", "catalase reaction", "caperase activity", "catalase activity", "CAT"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O. [EC:1.11.1.6]", "canonical_name": "catalase-peroxidase activity"}
{"concept_id": "C1151517", "aliases": [], "types": ["T044"], "canonical_name": "manganese catalase activity"}
{"concept_id": "C1151518", "aliases": ["myeloperoxidase activity", "peroxidase activity", "MPO", "oxyperoxidase activity", "peroxidase reaction"], "types": ["T044"], "definition": "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. [GOC:curators]", "canonical_name": "donor:hydrogen-peroxide oxidoreductase activity"}
{"concept_id": "C1151519", "aliases": ["bromide peroxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 R-H + 2 bromide + hydrogen peroxide = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide. [EC:1.11.1.18]", "canonical_name": "bromoperoxidase activity"}
{"concept_id": "C1151520", "aliases": ["chloride:hydrogen-peroxide oxidoreductase", "chloride peroxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 R-H + 2 chloride + hydrogen peroxide = 2 R-Cl + 2 H2O. [EC:1.11.1.10]", "canonical_name": "chloroperoxidase activity"}
{"concept_id": "C1151524", "aliases": [], "types": ["T044"], "canonical_name": "vanadium chloroperoxidase activity"}
{"concept_id": "C1151525", "aliases": ["apocytochrome c peroxidase activity", "cytochrome c-551 peroxidase activity", "cytochrome peroxidase activity", "cytochrome-c peroxidase activity", "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity", "cytochrome c-H2O oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O. [EC:1.11.1.5]", "canonical_name": "cytochrome c peroxidase activity"}
{"concept_id": "C1151526", "aliases": ["diarylpropane peroxidase activity", "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)", "LiP activity", "lignin peroxidase activity", "ligninase activity", "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O. [EC:1.11.1.14]", "canonical_name": "diarylpropane oxygenase activity"}
{"concept_id": "C1151527", "aliases": [], "types": ["T044"], "canonical_name": "eosinophil peroxidase activity"}
{"concept_id": "C1151528", "aliases": ["reduced glutathione peroxidase activity", "selenium-glutathione peroxidase activity", "GSH peroxidase activity", "glutathione:hydrogen-peroxide oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. [EC:1.11.1.9]", "canonical_name": "glutathione peroxidase activity"}
{"concept_id": "C1151530", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O. [RHEA:23336]", "canonical_name": "iodide peroxidase activity"}
{"concept_id": "C1151531", "aliases": ["L-ascorbate peroxidase activity", "L-ascorbic acid peroxidase activity", "ascorbic acid peroxidase activity", "L-ascorbate:hydrogen-peroxide oxidoreductase activity", "ascorbate peroxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O. [EC:1.11.1.11]", "canonical_name": "L-ascorbic acid-specific peroxidase activity"}
{"concept_id": "C1151532", "aliases": [], "types": ["T044"], "canonical_name": "lactoperoxidase activity"}
{"concept_id": "C1151533", "aliases": ["Mn-dependent (NADH-oxidizing) peroxidase activity", "Mn-dependent peroxidase activity", "manganese peroxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O. [EC:1.11.1.13]", "canonical_name": "Mn(II):hydrogen-peroxide oxidoreductase activity"}
{"concept_id": "C1151535", "aliases": ["NADH:hydrogen-peroxide oxidoreductase activity", "NADH-peroxidase activity", "diphosphopyridine nucleotide peroxidase activity", "NADH peroxidase activity", "DPNH peroxidase activity", "nicotinamide adenine dinucleotide peroxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O(2) + H(+) + NADH = 2 H(2)O + NAD(+). [EC:1.11.1.1, RHEA:18509]", "canonical_name": "NAD peroxidase activity"}
{"concept_id": "C1151538", "aliases": ["TrxPx activity", "TPx activity", "thioredoxin peroxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. [RHEA:63528]", "canonical_name": "thiol peroxidase activity"}
{"concept_id": "C1151539", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on phosphorus or arsenic in donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:mah]"}
{"concept_id": "C1151540", "aliases": ["oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide. [GOC:mah]"}
{"concept_id": "C1151541", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on reduced flavodoxin as donor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151542", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen. [GOC:jl]"}
{"concept_id": "C1151543", "aliases": [], "types": ["T044"], "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. [GOC:mah]", "canonical_name": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"}
{"concept_id": "C1151544", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached. [UM-BBD_enzymeID:e0255]", "canonical_name": "1,2-dihydroxynaphthalene dioxygenase activity"}
{"concept_id": "C1151545", "aliases": [], "types": ["T044"], "canonical_name": "3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate. [UM-BBD_enzymeID:e0309]"}
{"concept_id": "C1151546", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor. [GOC:mah]"}
{"concept_id": "C1151547", "aliases": [], "types": ["T044"], "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. [GOC:mah]", "canonical_name": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"}
{"concept_id": "C1151548", "aliases": ["1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity"], "types": ["T044"], "canonical_name": "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate. [UM-BBD_reactionID:r0442]"}
{"concept_id": "C1151549", "aliases": ["1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity"], "types": ["T044"], "canonical_name": "1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity", "definition": "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate. [UM-BBD_reactionID:r0324]"}
{"concept_id": "C1151550", "aliases": ["1-hydroxy-2-naphthoate dioxygenase activity", "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)", "1-hydroxy-2-naphthoate 1,2-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate. [EC:1.13.11.38]", "canonical_name": "1-hydroxy-2-naphthoic acid dioxygenase activity"}
{"concept_id": "C1151551", "aliases": [], "types": ["T044"], "canonical_name": "2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate. [UM-BBD_reactionID:r0457]"}
{"concept_id": "C1151552", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate). [UM-BBD_enzymeID:e0032]", "canonical_name": "2,2',3-trihydroxybiphenyl dioxygenase activity"}
{"concept_id": "C1151553", "aliases": [], "types": ["T044"], "canonical_name": "2,3-dihydroxy DDT 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate. [UM-BBD_reactionID:r0452]"}
{"concept_id": "C1151554", "aliases": [], "types": ["T044"], "canonical_name": "2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate. [UM-BBD_reactionID:r0310]"}
{"concept_id": "C1151557", "aliases": ["2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)", "2,3-dihydroxybenzoate 1,2-dioxygenase activity", "2,3-dihydroxybenzoate 3,4-dioxygenase activity", "o-pyrocatechuate oxygenase activity", "2,3-dihydroxybenzoic oxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). [EC:1.13.11.14, RHEA:18477]", "canonical_name": "2,3-dihydroxybenzoate oxygenase activity"}
{"concept_id": "C1151558", "aliases": ["biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)", "2,3-dihydroxybiphenyl 1,2-dioxygenase activity", "biphenyl-2,3-diol dioxygenase activity", "BphC", "biphenyl-2,3-diol 1,2-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O. [EC:1.13.11.39]", "canonical_name": "2,3-dihydroxybiphenyl-1,2-dioxygenase activity"}
{"concept_id": "C1151559", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate. [UM-BBD_enzymeID:e0422]", "canonical_name": "2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity"}
{"concept_id": "C1151560", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde. [UM-BBD_reactionID:r0305]", "canonical_name": "2-aminophenol 1,6-dioxygenase activity"}
{"concept_id": "C1151561", "aliases": [], "types": ["T044"], "canonical_name": "2-nitropropane dioxygenase activity"}
{"concept_id": "C1151562", "aliases": [], "types": ["T044"], "canonical_name": "3,4-dihydroxyphenanthrene dioxygenase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate. [UM-BBD_reactionID:r0501]"}
{"concept_id": "C1151563", "aliases": ["HPC dioxygenase activity", "homoprotocatechuate 2,3-dioxygenase activity", "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)", "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity"], "types": ["T044"], "canonical_name": "3,4-dihydroxyphenylacetate 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O(2) = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H(+). [EC:1.13.11.15, RHEA:15633]"}
{"concept_id": "C1151564", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate. [UM-BBD_reactionID:r0276]", "canonical_name": "3,5-dichlorocatechol 1,2-dioxygenase activity"}
{"concept_id": "C1151565", "aliases": ["3-hydroxyanthranilic acid dioxygenase activity", "3HAO", "3-hydroxyanthranilate 3,4-dioxygenase activity", "3-hydroxyanthranilic acid oxygenase activity", "3-hydroxyanthranilic oxygenase activity", "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). [EC:1.13.11.6, RHEA:17953]", "canonical_name": "3-hydroxyanthranilate oxygenase activity"}
{"concept_id": "C1151566", "aliases": ["4-hydroxyphenylpyruvate dioxygenase activity", "p-hydroxyphenylpyruvic hydroxylase activity", "p-hydroxyphenylpyruvate oxidase activity", "4-hydroxyphenylpyruvic acid dioxygenase activity", "p-hydroxyphenylpyruvic acid hydroxylase activity", "p-hydroxyphenylpyruvate dioxygenase activity", "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)", "p-hydroxyphenylpyruvic oxidase activity", "p-hydroxyphenylpyruvate hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. [EC:1.13.11.27]", "canonical_name": "4-hydroxyphenylpyruvate hydroxylase activity"}
{"concept_id": "C1151567", "aliases": [], "types": ["T044"], "canonical_name": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity", "definition": "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon. [UM-BBD_reactionID:r0049]"}
{"concept_id": "C1151568", "aliases": ["nine-cis-epoxycarotenoid dioxygenase activity", "NCED", "VP14", "9-cis-epoxycarotenoid 11,12-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al. [EC:1.13.11.51]", "canonical_name": "9-cis-epoxycarotenoid dioxygenase activity"}
{"concept_id": "C1151569", "aliases": ["12-lipoxygenase activity", "delta12-lipoxygenase activity", "arachidonate 12(S)-lipoxygenase activity", "12S-lipoxygenase activity", "leukotriene A4 synthase", "LTA4 synthase activity", "C-12 lipoxygenase activity", "12Delta-lipoxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. [EC:1.13.11.31, RHEA:10428]", "canonical_name": "arachidonate:oxygen 12-oxidoreductase activity"}
{"concept_id": "C1151570", "aliases": ["5-delta-lipoxygenase activity", "leukotriene-A4 synthase activity", "arachidonic acid 5-lipoxygenase activity", "5Delta-lipoxygenase activity", "delta(5)-lipoxygenase activity", "delta5-lipoxygenase activity", "leukotriene A4 synthase", "5-lipoxygenase activity", "arachidonate 5-lipoxygenase activity", "arachidonic 5-lipoxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. [EC:1.13.11.34, RHEA:32307]", "canonical_name": "arachidonate:oxygen 5-oxidoreductase activity"}
{"concept_id": "C1151571", "aliases": ["carotene dioxygenase activity", "beta-carotene 15,15'-monooxygenase activity", "beta-carotene 15,15'-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal. [RHEA:32887]", "canonical_name": "carotene 15,15'-dioxygenase activity"}
{"concept_id": "C1151572", "aliases": ["carbazole 1,9alpha-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol. [UM-BBD_reactionID:r0456]", "canonical_name": "carbazole 1,9a-dioxygenase activity"}
{"concept_id": "C1151573", "aliases": [], "types": ["T044"], "canonical_name": "catechol dioxygenase activity", "definition": "Catalysis of the reaction: catechol + O2 = a muconate. [GOC:mah, MetaCyc:CATECHOL-12-DIOXYGENASE-RXN, MetaCyc:CATECHOL-23-DIOXYGENASE-RXN]"}
{"concept_id": "C1151574", "aliases": ["catechol-oxygen 1,2-oxidoreductase activity", "CD II", "pyrocatechol 1,2-dioxygenase activity", "1,2-pyrocatechase activity", "catechol:oxygen 1,2-oxidoreductase activity", "CD I", "catechol 1,2-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: catechol + O2 = cis,cis-muconate. [EC:1.13.11.1]", "canonical_name": "catechol 1,2-oxygenase activity"}
{"concept_id": "C1151575", "aliases": ["pyrocatechol 2,3-dioxygenase", "catechol:oxygen 2,3-oxidoreductase (decyclizing)", "2,3-pyrocatechase activity", "catechol 2,3-dioxygenase activity", "catechol oxygenase"], "types": ["T044"], "definition": "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde. [EC:1.13.11.2]", "canonical_name": "catechol 2,3-oxygenase"}
{"concept_id": "C1151576", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate. [UM-BBD_reactionID:r0655]", "canonical_name": "chlorocatechol 1,2-dioxygenase activity"}
{"concept_id": "C1151577", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+). [EC:1.13.11.20, RHEA:20441]", "canonical_name": "cysteine dioxygenase activity"}
{"concept_id": "C1151578", "aliases": [], "types": ["T044"], "canonical_name": "dihydroxydibenzothiophene dioxygenase activity", "definition": "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. [UM-BBD_reactionID:r0162]"}
{"concept_id": "C1151579", "aliases": [], "types": ["T044"], "canonical_name": "dihydroxyfluorene dioxygenase activity", "definition": "Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid. [GOC:mah, UM-BBD_reactionID:r0415, UM-BBD_reactionID:r0422]"}
{"concept_id": "C1151582", "aliases": ["homogentisic acid oxidase activity", "homogentisic oxygenase activity", "homogentisicase activity", "homogentisate 1,2-dioxygenase activity", "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)", "homogentisate oxidase activity", "homogentisate dioxygenase activity", "homogentisate oxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). [EC:1.13.11.5, RHEA:15449]", "canonical_name": "homogentisic acid oxygenase activity"}
{"concept_id": "C1151583", "aliases": [], "types": ["T044"], "canonical_name": "hydroquinone 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde. [UM-BBD_reactionID:r0228]"}
{"concept_id": "C1151584", "aliases": ["hydroxyquinol 1,2-dioxygenase activity", "benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate. [EC:1.13.11.37]", "canonical_name": "hydroxyquinol dioxygenase activity"}
{"concept_id": "C1151586", "aliases": ["linoleate 13S-lipoxygenase activity", "lipoxydase activity", "lionoleate:O2 oxidoreductase activity", "linoleate:oxygen 13-oxidoreductase activity", "lipoperoxidase activity", "fat oxidase activity", "lipoxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. [EC:1.13.11.12, GOC:lb]", "canonical_name": "lipoxidase activity"}
{"concept_id": "C1151587", "aliases": [], "types": ["T044"], "canonical_name": "p-cumate 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate. [RHEA:42344]"}
{"concept_id": "C1151588", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene. [UM-BBD_reactionID:r0455]", "canonical_name": "phenanthrene dioxygenase activity"}
{"concept_id": "C1151589", "aliases": ["protocatechuate 3,4-dioxygenase activity", "protocatechuic acid oxidase activity", "protocatechuic 3,4-dioxygenase activity", "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate. [EC:1.13.11.3]", "canonical_name": "protocatechuic 3,4-oxygenase activity"}
{"concept_id": "C1151590", "aliases": [], "types": ["T044"], "canonical_name": "protocatechuate 3,4-dioxygenase type II activity", "definition": "Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate. [UM-BBD_reactionID:r0581]"}
{"concept_id": "C1151591", "aliases": ["protocatechuic 4,5-dioxygenase activity", "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)", "protocatechuic 4,5-oxygenase activity", "protocatechuate 4,5-oxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde. [EC:1.13.11.8]", "canonical_name": "protocatechuate 4,5-dioxygenase activity"}
{"concept_id": "C1151592", "aliases": ["quercetinase activity", "quercetin:oxygen 2,3-oxidoreductase (decyclizing)", "quercetin 2,3-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. [EC:1.13.11.24, RHEA:15381]", "canonical_name": "flavonol 2,4-oxygenase activity"}
{"concept_id": "C1151593", "aliases": [], "types": ["T044"], "canonical_name": "styrene dioxygenase activity", "definition": "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol. [UM-BBD_reactionID:r0256]"}
{"concept_id": "C1151594", "aliases": ["tryptophan 2,3-dioxygenase activity", "tryptamin 2,3-dioxygenase activity", "L-tryptophan pyrrolase activity", "tryptamine 2,3-dioxygenase activity", "indoleamine-pyrrole 2,3-dioxygenase activity", "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)", "L-tryptophan 2,3-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. [EC:1.13.11.11]", "canonical_name": "TDO"}
{"concept_id": "C1151595", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous", "definition": "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized. [GOC:ai]"}
{"concept_id": "C1151596", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol. [UM-BBD_reactionID:r0359]", "canonical_name": "2,4,5-trichlorophenoxyacetic acid oxygenase activity"}
{"concept_id": "C1151597", "aliases": ["oxidoreductase activity, acting on sulphur group of donors"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on a sulfur group of donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151598", "aliases": ["oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome. [GOC:jl]"}
{"concept_id": "C1151599", "aliases": ["oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. [GOC:jl]"}
{"concept_id": "C1151600", "aliases": ["acetylmethionine sulfoxide reductase activity", "methionine-S-oxide reductase activity", "methionine S-oxide reductase activity", "methionine sulfoxide reductase activity", "fSMsr", "methyl sulfoxide reductase I and II activity", "L-methionine-(S)-S-oxide reductase activity", "free-methionine (S)-S-oxide reductase activity", "L-methionine:oxidized-thioredoxin S-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. [EC:1.8.4.13]", "canonical_name": "L-methionine:thioredoxin-disulfide S-oxidoreductase activity"}
{"concept_id": "C1151601", "aliases": ["adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)", "3'-phosphoadenylylsulfate reductase activity", "PAPS reductase activity", "PAPS sulfotransferase activity", "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity", "PAdoPS reductase activity", "phosphoadenylyl-sulphate reductase (thioredoxin) activity", "PAPS reductase, thioredoxin-dependent activity", "phosphoadenylyl-sulfate reductase (thioredoxin) activity", "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)", "thioredoxin:3'-phospho-adenylylsulfate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. [EC:1.8.4.8, RHEA:11724]", "canonical_name": "phosphoadenosine-phosphosulfate reductase activity"}
{"concept_id": "C1151602", "aliases": ["glutathione:protein-disulfide oxidoreductase activity", "protein disulfide transhydrogenase activity", "glutathione-insulin transhydrogenase activity", "glutathione-protein disulfide oxidoreductase activity", "insulin reductase activity", "protein disulfide reductase (glutathione)", "protein-disulfide reductase (glutathione) activity", "thiol:protein-disulfide oxidoreductase activity", "glutathione--insulin transhydrogenase activity", "thiol-protein disulphide oxidoreductase activity", "GSH-insulin transhydrogenase activity", "reductase, protein disulfide (glutathione)", "protein-disulfide isomerase/oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol. [RHEA:21064]", "canonical_name": "protein-disulphide reductase (glutathione) activity"}
{"concept_id": "C1151604", "aliases": ["methionine sulphoxide reductase A activity", "MsrA", "peptide-methionine-(S)-S-oxide reductase activity", "peptide methionine sulfoxide reductase activity", "methionine sulfoxide (protein) reductase activity", "methionine sulfoxide reductase A activity", "protein-methionine-S-oxide reductase activity", "peptide-methionine (S)-S-oxide reductase activity", "peptide Met(O) reductase activity", "methionine S-oxide reductase (S-form oxidizing) activity"], "types": ["T044"], "definition": "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920]", "canonical_name": "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity"}
{"concept_id": "C1151605", "aliases": ["oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:jl]"}
{"concept_id": "C1151607", "aliases": ["protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase", "lipoamide oxidoreductase (NADH) activity", "lipoamide dehydrogenase (NADH) activity", "lipoamide reductase activity", "lipoyl dehydrogenase activity", "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase", "dihydrothioctic dehydrogenase activity", "dihydrolipoamide:NAD+ oxidoreductase", "lipoate dehydrogenase activity", "dihydrolipoyl dehydrogenase activity", "dehydrolipoate dehydrogenase activity", "diaphorase activity", "lipoamide reductase (NADH) activity", "lipoic acid dehydrogenase activity", "dihydrolipoic dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. [EC:1.8.1.4]", "canonical_name": "dihydrolipoamide dehydrogenase activity"}
{"concept_id": "C1151608", "aliases": ["sulphite reductase (NADPH) activity", "hydrogen-sulfide:NADP+ oxidoreductase activity", "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "H2S-NADP oxidoreductase activity", "NADPH-dependent sulfite reductase activity", "NADPH-sulfite reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+. [RHEA:13801]", "canonical_name": "sulfite reductase (NADPH) activity"}
{"concept_id": "C1151609", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on sulfur group of donors, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome. [GOC:jl]"}
{"concept_id": "C1151610", "aliases": ["dimethyl sulphoxide reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O. [UM-BBD_reactionID:r0207]", "canonical_name": "dimethyl sulfoxide reductase activity"}
{"concept_id": "C1151611", "aliases": ["trithionate:(acceptor) oxidoreductase activity", "bisulfite reductase activity", "dissimilatory-type sulfite reductase activity", "hydrogensulphite reductase activity", "trithionate:acceptor oxidoreductase activity", "hydrogensulfite reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: trithionate + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor. [EC:1.8.99.3]", "canonical_name": "dissimilatory sulfite reductase activity"}
{"concept_id": "C1151612", "aliases": ["assimilatory-type sulfite reductase activity", "hydrogen-sulfide:acceptor oxidoreductase activity", "assimilatory sulfite reductase activity", "sulfite reductase activity", "hydrogen-sulfide:(acceptor) oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor. [GOC:curators]", "canonical_name": "sulphite reductase activity"}
{"concept_id": "C1151613", "aliases": ["tetrachlorohydroquinone reductive dehalogenase activity"], "types": ["T044"], "canonical_name": "tetrachloro-p-hydroquinone reductive dehalogenase activity", "definition": "Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl. [UM-BBD_reactionID:r0314]"}
{"concept_id": "C1151614", "aliases": ["oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]"}
{"concept_id": "C1151615", "aliases": ["(MM)-oxidase activity", "methanethiol oxidase activity", "methanethiol:oxygen oxidoreductase activity", "MT-oxidase activity", "methyl mercaptan oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide. [EC:1.8.3.4]", "canonical_name": "methylmercaptan oxidase activity"}
{"concept_id": "C1151616", "aliases": ["sulphite oxidase activity", "sulfite oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate. [EC:1.8.3.1, RHEA:24600]", "canonical_name": "sulfite:oxygen oxidoreductase activity"}
{"concept_id": "C1151617", "aliases": ["oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound. [GOC:jl]"}
{"concept_id": "C1151618", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on superoxide radicals as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151619", "aliases": ["SOD-3", "SOD-4", "Mn-SOD", "SOD-2", "erythrocuprein", "SOD-1", "cytocuprein", "superoxide:superoxide oxidoreductase activity", "superoxide dismutase activity", "SOD", "hemocuprein", "SODS", "SODF"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. [EC:1.15.1.1, GOC:vw, PMID:15064408]", "canonical_name": "Fe-SOD"}
{"concept_id": "C1151620", "aliases": [], "types": ["T044"], "canonical_name": "zinc superoxide oxidoreductase"}
{"concept_id": "C1151621", "aliases": [], "types": ["T044"], "canonical_name": "iron superoxide dismutase activity"}
{"concept_id": "C1151622", "aliases": [], "types": ["T044"], "canonical_name": "manganese superoxide dismutase activity"}
{"concept_id": "C1151623", "aliases": [], "types": ["T044"], "canonical_name": "nickel superoxide dismutase activity"}
{"concept_id": "C1151624", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151625", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxybutaraldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate. [UM-BBD_reactionID:r0014]"}
{"concept_id": "C1151626", "aliases": [], "types": ["T044"], "canonical_name": "myrtenal dehydrogenase activity", "definition": "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid. [UM-BBD_reactionID:r0711]"}
{"concept_id": "C1151627", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome. [GOC:jl]"}
{"concept_id": "C1151628", "aliases": ["carbon monoxide,water:cytochrome b-561 oxidoreductase activity", "carbon monoxide oxidase activity", "carbon-monoxide oxygenase activity", "carbon monoxide oxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561. [GOC:curators, RHEA:48880]", "canonical_name": "carbon-monoxide dehydrogenase (cytochrome b-561)"}
{"concept_id": "C1151630", "aliases": ["oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. [GOC:jl]"}
{"concept_id": "C1151631", "aliases": ["3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity", "alpha-oxoisocaproate dehydrogenase activity", "alpha-ketoisocaproic dehydrogenase activity", "dehydrogenase, 2-oxoisovalerate (lipoate) activity", "alpha-keto-alpha-methylvalerate dehydrogenase activity", "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity", "3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity", "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)", "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity", "2-oxoisovalerate (lipoate) dehydrogenase activity", "alpha-ketoisocaproate dehydrogenase activity", "alpha-ketoisovalerate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. [EC:1.2.4.4]", "canonical_name": "2-oxoisocaproate dehydrogenase activity"}
{"concept_id": "C1151632", "aliases": ["alpha-ketoglutarate dehydrogenase activity", "oxoglutarate dehydrogenase (succinyl-transferring) activity", "alpha-oxoglutarate dehydrogenase activity", "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)", "ketoglutaric dehydrogenase activity", "OGDC activity", "alpha-ketoglutaric dehydrogenase activity", "oxoglutarate dehydrogenase activity", "AKGDH activity", "2-oxoglutarate: lipoate oxidoreductase activity", "2-ketoglutarate dehydrogenase activity", "oxoglutarate decarboxylase activity", "oxoglutarate dehydrogenase (lipoamide) activity", "2-oxoglutarate dehydrogenase activity", "alpha-ketoglutaric acid dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. [EC:1.2.4.2]", "canonical_name": "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity"}
{"concept_id": "C1151633", "aliases": ["pyranose:acceptor oxidoreductase activity", "pyruvate dehydrogenase (acetyl-transferring) activity", "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)", "pyranose-quinone oxidoreductase activity", "pyruvate dehydrogenase (lipoamide) activity", "pyranose dehydrogenase (acceptor) activity", "pyranose dehydrogenase activity", "PDH", "quinone-dependent pyranose dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. [EC:1.2.4.1]", "canonical_name": "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity"}
{"concept_id": "C1151634", "aliases": ["oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:jl]"}
{"concept_id": "C1151635", "aliases": ["pyruvic-ferredoxin oxidoreductase activity", "pyruvate:ferredoxin oxidoreductase activity", "PFOR", "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)", "pyruvate-ferredoxin reductase activity", "pyruvate synthetase activity", "pyruvate oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+. [KEGG_REACTION:R01196]", "canonical_name": "pyruvate synthase activity"}
{"concept_id": "C1151636", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]"}
{"concept_id": "C1151637", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxy-2-naphthaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate. [UM-BBD_reactionID:r0485]"}
{"concept_id": "C1151638", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate. [UM-BBD_reactionID:r0490]", "canonical_name": "2-carboxybenzaldehyde dehydrogenase activity"}
{"concept_id": "C1151639", "aliases": ["alpha-ketobutyrate-ferredoxin oxidoreductase activity", "2-oxobutyrate synthase activity", "2-oxobutyrate-ferredoxin oxidoreductase activity", "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)", "alpha-ketobutyrate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin. [GOC:curators]", "canonical_name": "2-ketobutyrate synthase activity"}
{"concept_id": "C1151640", "aliases": ["4-formylbenzenesulphonate dehydrogenase activity", "toluene-sulfonate aldehyde dehydrogenase activity", "4-formylbenzenesulfonate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "4-formylbenzenesulfonate dehydrogenase activity", "definition": "Catalysis of the reaction: 4-formylbenzenesulfonate + H(2)O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH. [EC:1.2.1.62, RHEA:18833]"}
{"concept_id": "C1151641", "aliases": ["4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "4-hydroxymuconic-semialdehyde dehydrogenase activity", "definition": "Catalysis of the reaction: <stereo>cis,trans</stereo>-4-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 2 H(+) + maleylacetate + NADH. [EC:1.2.1.61, RHEA:22420]"}
{"concept_id": "C1151642", "aliases": ["carboxymethylhydroxymuconic semialdehyde dehydrogenase activity", "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+. [EC:1.2.1.60]"}
{"concept_id": "C1151643", "aliases": ["6-oxohexanoate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+. [EC:1.2.1.63]", "canonical_name": "6-oxohexanoate:NADP+ oxidoreductase activity"}
{"concept_id": "C1151644", "aliases": ["aldehyde dehydrogenase (acylating) activity", "DmpF", "acetaldehyde dehydrogenase (acetylating) activity", "ADA", "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+. [EC:1.2.1.10]", "canonical_name": "acylating acetaldehyde dehydrogenase activity"}
{"concept_id": "C1151646", "aliases": ["aldehyde:NAD(P)+ oxidoreductase activity", "ALDH"], "types": ["T044"], "definition": "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. [EC:1.2.1.5]", "canonical_name": "aldehyde dehydrogenase [NAD(P)+] activity"}
{"concept_id": "C1151647", "aliases": ["NAD-linked aldehyde dehydrogenase activity", "CoA-independent aldehyde dehydrogenase activity", "aldehyde:NAD+ oxidoreductase activity", "m-methylbenzaldehyde dehydrogenase activity", "aldehyde dehydrogenase (NAD) activity", "NAD-dependent 4-hydroxynonenal dehydrogenase activity", "propionaldehyde dehydrogenase activity", "NAD-dependent aldehyde dehydrogenase activity", "aldehyde dehydrogenase (NAD+) activity", "NAD-aldehyde dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. [EC:1.2.1.3]", "canonical_name": "aldehyde dehydrogenase (NAD+)"}
{"concept_id": "C1151648", "aliases": ["L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity", "L-aminoadipate-semialdehyde dehydrogenase activity", "alpha-aminoadipate-semialdehyde dehydrogenase activity", "aminoadipate-semialdehyde dehydrogenase activity", "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity", "2-aminoadipic semialdehyde dehydrogenase activity", "2-aminoadipate semialdehyde dehydrogenase activity", "AAR", "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase", "alpha-aminoadipate reductase activity", "aminoadipate semialdehyde dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. [EC:1.2.1.31]", "canonical_name": "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity"}
{"concept_id": "C1151649", "aliases": ["gamma-aminobutyraldehyde dehydroganase activity", "4-aminobutanal:NAD+ 1-oxidoreductase activity", "4-aminobutanal dehydrogenase activity", "aminobutyraldehyde dehydrogenase activity", "4-aminobutyraldehyde dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+. [EC:1.2.1.19]", "canonical_name": "ABAL dehydrogenase activity"}
{"concept_id": "C1151651", "aliases": ["ASA dehydrogenase activity", "L-aspartate-beta-semialdehyde dehydrogenase activity", "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)", "aspartic beta-semialdehyde dehydrogenase activity", "aspartic semialdehyde dehydrogenase activity", "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)", "aspartate semialdehyde dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH. [EC:1.2.1.11, RHEA:24284]", "canonical_name": "aspartate-semialdehyde dehydrogenase activity"}
{"concept_id": "C1151652", "aliases": [], "types": ["T044"], "canonical_name": "benzaldehyde dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+. [EC:1.2.1.28, EC:1.2.1.7]"}
{"concept_id": "C1151653", "aliases": ["benzaldehyde:NAD+ oxidoreductase activity", "benzaldehyde dehydrogenase (NAD+) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. [EC:1.2.1.28]", "canonical_name": "benzaldehyde (NAD) dehydrogenase activity"}
{"concept_id": "C1151654", "aliases": ["benzaldehyde dehydrogenase (NADP+) activity", "NADP-linked benzaldehyde dehydrogenase"], "types": ["T044"], "definition": "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+. [EC:1.2.1.7]", "canonical_name": "benzaldehyde:NADP+ oxidoreductase"}
{"concept_id": "C1151655", "aliases": ["BADH activity", "betaine aldehyde dehydrogenase activity", "betaine-aldehyde:NAD+ oxidoreductase activity", "BetB", "betaine aldehyde oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+. [EC:1.2.1.8]", "canonical_name": "betaine-aldehyde dehydrogenase activity"}
{"concept_id": "C1151656", "aliases": ["cinnamoyl-CoA reductase activity", "cinnamoyl-coenzyme A reductase activity", "cinnamoyl-CoA:NADPH reductase activity", "feruloyl-CoA reductase activity", "p-hydroxycinnamoyl coenzyme A reductase activity", "ferulyl-CoA reductase activity", "feruloyl coenzyme A reductase activity", "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+. [EC:1.2.1.44]", "canonical_name": "cinnamoyl CoA reductase activity"}
{"concept_id": "C1151657", "aliases": [], "types": ["T044"], "canonical_name": "cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "definition": "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid. [UM-BBD_reactionID:r0744]"}
{"concept_id": "C1151658", "aliases": ["erythrose 4-phosphate dehydrogenase activity", "E4P dehydrogenase activity", "D-erythrose 4-phosphate:NAD+ oxidoreductase activity", "GapB", "E4PDH", "Epd dehydrogenase activity"], "types": ["T044"], "canonical_name": "erythrose-4-phosphate dehydrogenase activity", "definition": "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH. [EC:1.2.1.72, RHEA:12056]"}
{"concept_id": "C1151660", "aliases": ["formic hydrogen-lyase", "NAD-formate dehydrogenase", "formate dehydrogenase (NAD+) activity", "formate hydrogenlyase", "formate-NAD oxidoreductase", "NAD-dependent formate dehydrogenase", "formate dehydrogenase (NAD)"], "types": ["T044"], "definition": "Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH. [EC:1.17.1.9, RHEA:15985]", "canonical_name": "formic acid dehydrogenase"}
{"concept_id": "C1151661", "aliases": ["glutamate-gamma-semialdehyde dehydrogenase activity", "glutamyl-gamma-semialdehyde dehydrogenase activity", "gamma-glutamylphosphate reductase activity", "glutamylphosphate reductase activity", "glutamate semialdehyde dehydrogenase activity", "glutamate-phosphate reductase activity", "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)", "glutamate-5-semialdehyde dehydrogenase activity", "gamma-glutamyl phosphate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH. [EC:1.2.1.41, RHEA:19541]", "canonical_name": "beta-glutamylphosphate reductase activity"}
{"concept_id": "C1151662", "aliases": ["glutamyl-tRNA reductase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH. [EC:1.2.1.70, RHEA:12344]", "canonical_name": "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)"}
{"concept_id": "C1151663", "aliases": ["formaldehyde dehydrogenase activity", "glutathione-independent formaldehyde dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH. [EC:1.2.1.46, RHEA:16425]", "canonical_name": "formaldehyde:NAD+ oxidoreductase activity"}
{"concept_id": "C1151666", "aliases": ["NADP-glyceraldehyde-3-phosphate dehydrogenase activity", "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity", "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity", "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity", "glyceraldehyde-3-phosphate dehydrogenase (NADP)", "glyceraldehyde-3-phosphate:NADP reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(2)O + NADP(+) = 3-phospho-D-glycerate + 2 H(+) + NADPH. [EC:1.2.1.9, RHEA:14669]", "canonical_name": "glyceraldehyde 3-phosphate dehydrogenase (NADP)"}
{"concept_id": "C1151667", "aliases": ["lactaldehyde dehydrogenase activity", "(S)-lactaldehyde:NAD+ oxidoreductase activity", "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+. [EC:1.2.1.22]", "canonical_name": "L-lactaldehyde:NAD oxidoreductase activity"}
{"concept_id": "C1151668", "aliases": ["malonic semialdehyde oxidative decarboxylase activity", "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)"], "types": ["T044"], "canonical_name": "malonate-semialdehyde dehydrogenase (acetylating) activity", "definition": "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+. [EC:1.2.1.18]"}
{"concept_id": "C1151669", "aliases": ["MSDH activity", "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)", "methylmalonate-semialdehyde dehydrogenase (acylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. [EC:1.2.1.27]", "canonical_name": "MMSA dehydrogenase activity"}
{"concept_id": "C1151670", "aliases": ["N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)", "reductase, acetyl-gamma-glutamyl phosphate", "N-acetylglutamate 5-semialdehyde dehydrogenase activity", "N-acetyl-gamma-glutamyl-phosphate reductase activity", "N-acetylglutamic gamma-semialdehyde dehydrogenase activity", "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. [EC:1.2.1.38]", "canonical_name": "N-acetyl-glutamate semialdehyde dehydrogenase activity"}
{"concept_id": "C1151671", "aliases": ["3-hydroxybenzaldehyde:NAD+ oxidoreductase activity", "4-hydroxybenzaldehyde dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+. [EC:1.2.1.64]", "canonical_name": "p-hydroxybenzaldehyde dehydrogenase activity"}
{"concept_id": "C1151672", "aliases": ["phenylacetaldehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+. [EC:1.2.1.39]", "canonical_name": "phenylacetaldehyde dehydrogenase activity"}
{"concept_id": "C1151673", "aliases": ["salicylaldehyde dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+. [EC:1.2.1.65]", "canonical_name": "salicylaldehyde:NAD+ oxidoreductase activity"}
{"concept_id": "C1151674", "aliases": ["succinate semialdehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "succinate-semialdehyde dehydrogenase activity"}
{"concept_id": "C1151675", "aliases": ["succinate-semialdehyde dehydrogenase [NAD(P)+] activity", "succinate-semialdehyde:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+. [EC:1.2.1.16]", "canonical_name": "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))"}
{"concept_id": "C1151676", "aliases": [], "types": ["T044"], "canonical_name": "trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "definition": "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid. [UM-BBD_reactionID:r0745]"}
{"concept_id": "C1151677", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome. [GOC:jl]"}
{"concept_id": "C1151678", "aliases": ["carbon-monoxide dehydrogenase (acceptor) activity", "carbon-monoxide:acceptor oxidoreductase activity", "anaerobic carbon monoxide dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor. [EC:1.2.7.4]", "canonical_name": "carbon monoxide dehydrogenase activity"}
{"concept_id": "C1151679", "aliases": ["formylmethanofuran:acceptor oxidoreductase activity", "formylmethanofuran:(acceptor) oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-formylmethanofuran + A + H(2)O + H(+) = AH(2) + CO(2) + methanofuran. [EC:1.2.7.12, RHEA:19841]", "canonical_name": "formylmethanofuran dehydrogenase activity"}
{"concept_id": "C1151680", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]"}
{"concept_id": "C1151681", "aliases": [], "types": ["T044"], "canonical_name": "2-butanone oxidase activity", "definition": "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate. [UM-BBD_reactionID:r0169]"}
{"concept_id": "C1151682", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxyphenylpyruvate oxidase activity", "definition": "Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O(2) = 2 (4-hydroxyphenyl)acetate + 2 CO(2). [EC:1.2.3.13, RHEA:17197]"}
{"concept_id": "C1151683", "aliases": ["aldehyde:oxygen oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide. [EC:1.2.3.1]", "canonical_name": "aldehyde oxidase activity"}
{"concept_id": "C1151684", "aliases": ["aryl-aldehyde:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "aryl-aldehyde oxidase activity", "definition": "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide. [EC:1.2.3.9]"}
{"concept_id": "C1151685", "aliases": ["pyridoxal:oxygen 4-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide. [EC:1.2.3.8]", "canonical_name": "pyridoxal oxidase activity"}
{"concept_id": "C1151686", "aliases": ["vanillate:oxygen oxidoreductase (demethylating)", "vanillate demethylase activity", "4-hydroxy-3-methoxybenzoate demethylase activity", "vanillate demethylase (aerobic) activity"], "types": ["T044"], "canonical_name": "vanillate monooxygenase activity", "definition": "Catalysis of the reaction: H(+) + NADH + O(2) + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H(2)O + NAD(+). [EC:1.14.13.82, RHEA:13021]"}
{"concept_id": "C1151687", "aliases": [], "types": ["T044"], "canonical_name": "vanillate O-demethylase (anaerobic) activity", "definition": "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate. [UM-BBD_reactionID:r0758]"}
{"concept_id": "C1151688", "aliases": ["pyruvic acid dehydrogenase activity", "pyruvic dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the oxidative decarboxylation of pyruvate. [ISBN:0716720094]", "canonical_name": "pyruvate dehydrogenase activity"}
{"concept_id": "C1151689", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-CH group of donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151690", "aliases": ["DDMS dehydrogenase activity"], "types": ["T044"], "canonical_name": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity", "definition": "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS. [UM-BBD_reactionID:r0514]"}
{"concept_id": "C1151691", "aliases": [], "types": ["T044"], "canonical_name": "2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA. [UM-BBD_reactionID:r0205]"}
{"concept_id": "C1151692", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA. [UM-BBD_reactionID:r0192]"}
{"concept_id": "C1151693", "aliases": ["sterol-C5-desaturase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. [MetaCyc:RXN3O-227]", "canonical_name": "C-5 sterol desaturase activity"}
{"concept_id": "C1151694", "aliases": [], "types": ["T044"], "canonical_name": "carvone reductase activity", "definition": "Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone. [UM-BBD_reactionID:r0732]"}
{"concept_id": "C1151695", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome. [GOC:jl]"}
{"concept_id": "C1151696", "aliases": ["L-galactono-gamma-lactone dehydrogenase activity", "GLDase activity", "L-galactonolactone dehydrogenase activity", "galactonolactone dehydrogenase activity", "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity", "L-galactono-1,4-lactone dehydrogenase activity", "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c. [EC:1.3.2.3]", "canonical_name": "GLDHase activity"}
{"concept_id": "C1151697", "aliases": ["oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:jl]"}
{"concept_id": "C1151698", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]"}
{"concept_id": "C1151699", "aliases": ["naphthalene dihydrodiol dehydrogenase activity", "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity", "cis-dihydrodiol naphthalene dehydrogenase activity", "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity", "cis-naphthalene dihydrodiol dehydrogenase activity", "(+)-cis-naphthalene dihydrodiol dehydrogenase activity"], "types": ["T044"], "canonical_name": "cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity", "definition": "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+. [EC:1.3.1.29]"}
{"concept_id": "C1151700", "aliases": ["1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity", "definition": "Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO(2) + NADH. [EC:1.3.1.68, RHEA:15657]"}
{"concept_id": "C1151702", "aliases": ["12-oxo-phytodienoate reductase activity", "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity", "12-oxo-phytodienoic acid reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + H(+) + NADPH. [EC:1.3.1.42, RHEA:21888]", "canonical_name": "12-oxophytodienoate reductase activity"}
{"concept_id": "C1151703", "aliases": ["2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity", "2,3-DHB dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH. [EC:1.3.1.28, RHEA:23824]", "canonical_name": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"}
{"concept_id": "C1151704", "aliases": ["biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity", "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity", "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity"], "types": ["T044"], "canonical_name": "cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity", "definition": "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+. [EC:1.3.1.56]"}
{"concept_id": "C1151705", "aliases": ["2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH. [EC:1.3.1.58, RHEA:23772]", "canonical_name": "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity"}
{"concept_id": "C1151706", "aliases": [], "types": ["T044"], "canonical_name": "2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity", "definition": "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate. [UM-BBD_enzymeID:e0308]"}
{"concept_id": "C1151707", "aliases": ["4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)"], "types": ["T044"], "canonical_name": "2,4-dichlorobenzoyl-CoA reductase activity", "definition": "Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH. [EC:1.3.1.63, RHEA:23076]"}
{"concept_id": "C1151708", "aliases": ["4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "4-enoyl-CoA reductase activity", "4-enoyl-CoA reductase (NADPH2)", "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity", "4-enoyl-CoA reductase (NADPH) activity"], "types": ["T044"], "canonical_name": "2,4-dienoyl-CoA reductase (NADPH) activity", "definition": "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+. [EC:1.3.1.34]"}
{"concept_id": "C1151709", "aliases": [], "types": ["T044"], "canonical_name": "2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity", "definition": "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone. [UM-BBD_reactionID:r0553]"}
{"concept_id": "C1151710", "aliases": ["4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity", "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity", "definition": "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2. [EC:1.3.1.67]"}
{"concept_id": "C1151711", "aliases": ["5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity", "definition": "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH. [EC:1.3.1.65, RHEA:24556]"}
{"concept_id": "C1151712", "aliases": [], "types": ["T044"], "canonical_name": "bilirubin:NAD(P)+ oxidoreductase activity"}
{"concept_id": "C1151713", "aliases": ["cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity", "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity", "cis-benzene glycol dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+. [EC:1.3.1.19]", "canonical_name": "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity"}
{"concept_id": "C1151714", "aliases": ["cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+. [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN]", "canonical_name": "benzoate cis-diol dehydrogenase activity"}
{"concept_id": "C1151715", "aliases": [], "types": ["T044"], "canonical_name": "cis-2,3-dihydrodiol DDT dehydrogenase activity", "definition": "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT. [UM-BBD_reactionID:r0451]"}
{"concept_id": "C1151716", "aliases": ["(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity", "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity"], "types": ["T044"], "canonical_name": "cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity", "definition": "Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol. [EC:1.3.1.49, RHEA:16253]"}
{"concept_id": "C1151717", "aliases": [], "types": ["T044"], "canonical_name": "cis-chlorobenzene dihydrodiol dehydrogenase activity", "definition": "Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol. [UM-BBD_enzymeID:e0411]"}
{"concept_id": "C1151718", "aliases": ["cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity", "cis-ethylbenzene glycol dehydrogenase activity"], "types": ["T044"], "canonical_name": "cis-dihydroethylcatechol dehydrogenase activity", "definition": "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH. [EC:1.3.1.66, RHEA:18101]"}
{"concept_id": "C1151719", "aliases": ["delta24(241)-sterol reductase activity", "sterol Delta(24(28))-methylene reductase activity", "D24(24-1)-sterol reductase activity", "ergosterol:NADP+ delta24(241)-oxidoreductase activity", "sterol delta-24(28) methylene reductase activity", "sterol delta-24(28) reductase activity", "sterol delta24(28)-methylene reductase activity", "C-24(28) sterol reductase activity", "sterol delta24(28)-reductase activity", "sterol Delta(24(28))-reductase activity"], "types": ["T044"], "canonical_name": "delta24(24-1) sterol reductase activity", "definition": "Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH. [EC:1.3.1.71, RHEA:18501]"}
{"concept_id": "C1151720", "aliases": ["cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "dibenzothiophene dihydrodiol dehydrogenase activity", "definition": "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH. [EC:1.3.1.60, RHEA:24188]"}
{"concept_id": "C1151722", "aliases": ["dihydropyrimidine dehydrogenase activity", "dihydrouracil dehydrogenase (NADP)", "DPD", "dihydrothymine dehydrogenase activity", "DHU dehydrogenase activity", "4,5-dihydrothymine: oxidoreductase activity", "hydropyrimidine dehydrogenase activity", "dihydropyrimidine dehydrogenase (NADP+) activity", "DHPDH", "dihydrouracil dehydrogenase (NADP+) activity", "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+. [EC:1.3.1.2]", "canonical_name": "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity"}
{"concept_id": "C1151723", "aliases": ["dihydrouracil dehydrogenase (NAD+) activity", "uracil reductase activity", "5,6-dihydrouracil:NAD+ oxidoreductase activity", "pyrimidine reductase activity"], "types": ["T044"], "canonical_name": "thymine reductase activity"}
{"concept_id": "C1151724", "aliases": ["acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)", "enoyl-ACp reductase activity", "enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "enoyl-acyl carrier protein reductase", "enoyl-[acyl-carrier protein] reductase activity", "enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity", "enoyl-[acyl-carrier-protein] reductase activity", "enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity", "enoyl-acyl-carrier-protein reductase (NADPH, A-specific)", "enoyl-ACP reductase (NADPH, A-specific) activity", "acyl-ACP dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+. [EC:1.3.1.39, MetaCyc:1.3.1.39-RXN]", "canonical_name": "enoyl-ACP reductase activity"}
{"concept_id": "C1151725", "aliases": ["NADH-enoyl acyl carrier protein reductase activity", "NADH-specific enoyl-ACP reductase activity", "enoyl-acyl-carrier-protein reductase (NADH)", "enoyl-[acyl-carrier protein] reductase (NADH) activity", "enoyl-ACP reductase (NADH) activity", "enoyl-[acyl-carrier-protein] reductase (NADH) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. [EC:1.3.1.9]", "canonical_name": "acyl-acyl-carrier-protein:NAD+ oxidoreductase"}
{"concept_id": "C1151726", "aliases": ["enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity", "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity", "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)", "enoyl-ACP reductase (NADPH, B-specific) activity", "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)", "enoyl acyl-carrier-protein reductase activity", "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)", "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+. [EC:1.3.1.10]", "canonical_name": "NADPH 2-enoyl Co A reductase activity"}
{"concept_id": "C1151727", "aliases": ["succinate:NAD+ oxidoreductase activity", "NADH-fumarate reductase activity", "fumarate reductase (NADH) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NAD(+) + succinate = fumarate + H(+) + NADH. [EC:1.3.1.6, RHEA:18281]", "canonical_name": "NADH-dependent fumarate reductase activity"}
{"concept_id": "C1151728", "aliases": ["maleylacetate reductase activity", "maleolylacetate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+. [EC:1.3.1.32]", "canonical_name": "3-oxoadipate:NAD(P)+ oxidoreductase activity"}
{"concept_id": "C1151729", "aliases": ["(S)-dihydroorotate:NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate. [EC:1.3.1.14, RHEA:13513]", "canonical_name": "orotate reductase (NADH) activity"}
{"concept_id": "C1151730", "aliases": ["dihydrophloroglucinol:NADP+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dihydrophloroglucinol + NADP(+) = H(+) + NADPH + phloroglucinol. [EC:1.3.1.57, RHEA:10080]", "canonical_name": "phloroglucinol reductase activity"}
{"concept_id": "C1151731", "aliases": ["cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "phthalate 4,5-cis-dihydrodiol dehydrogenase activity", "definition": "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH. [EC:1.3.1.64, RHEA:13837]"}
{"concept_id": "C1151732", "aliases": ["pimeloyl-CoA:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "pimeloyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(+) + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H(+) + NADH. [EC:1.3.1.62, RHEA:19665]"}
{"concept_id": "C1151733", "aliases": ["precorrin-6Y:NADP+ oxidoreductase activity", "precorrin-6X reductase activity", "precorrin-6B:NADP+ oxidoreductase activity", "precorrin-6A reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+. [EC:1.3.1.54]", "canonical_name": "precorrin-6Y:NADP(+) oxidoreductase activity"}
{"concept_id": "C1151734", "aliases": ["prephenate dehydrogenase (NAD+) activity", "chorismate mutase--prephenate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH. [EC:1.3.1.12, RHEA:13869]", "canonical_name": "prephenate:NAD+ oxidoreductase (decarboxylating)"}
{"concept_id": "C1151735", "aliases": ["prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity", "prephenate:NADP+ oxidoreductase (decarboxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH. [EC:1.3.1.13, RHEA:21640]", "canonical_name": "prephenate dehydrogenase (NADP+) activity"}
{"concept_id": "C1151736", "aliases": ["NADPH2-protochlorophyllide oxidoreductase activity", "protochlorophyllide reductase activity", "protochlorophyllide photooxidoreductase activity", "NADPH-protochlorophyllide oxidoreductase activity", "protochlorophyllide oxidoreductase activity", "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+. [EC:1.3.1.33]", "canonical_name": "NADPH-protochlorophyllide reductase activity"}
{"concept_id": "C1151738", "aliases": [], "types": ["T044"], "canonical_name": "trans-1,2-dihydrodiolphenanthrene dehydrogenase activity", "definition": "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene. [UM-BBD_reactionID:r0574]"}
{"concept_id": "C1151739", "aliases": ["acyl-CoA:NADP+ trans-2-oxidoreductase activity", "NADPH-dependent trans-2-enoyl-CoA reductase activity", "reductase, trans-enoyl coenzyme A"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+. [EC:1.3.1.38]", "canonical_name": "trans-2-enoyl-CoA reductase (NADPH) activity"}
{"concept_id": "C1151740", "aliases": [], "types": ["T044"], "canonical_name": "trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity", "definition": "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene. [UM-BBD_reactionID:r0575]"}
{"concept_id": "C1151741", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen. [GOC:jl]"}
{"concept_id": "C1151742", "aliases": ["steroid 5 alpha reductase", "3-keto-delta4-steroid-5alpha-reductase activity", "3-oxo-5alpha-steroid delta4-dehydrogenase activity", "steroid 5alpha-reductase", "4-ene-3-ketosteroid-5alpha-oxidoreductase activity", "delta4-5alpha-dehydrogenase activity", "3-oxo-5-alpha-steroid 4-dehydrogenase activity", "steroid delta4-5alpha-reductase activity", "delta4-3-ketosteroid5alpha-oxidoreductase activity", "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity", "delta4-3-oxo steroid reductase activity", "3-oxo-5alpha-steroid 4-dehydrogenase activity", "delta4-3-keto steroid 5alpha-reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. [EC:1.3.99.5]", "canonical_name": "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity"}
{"concept_id": "C1151743", "aliases": ["acyl dehydrogenase activity", "long-chain acyl-CoA dehydrogenase activity", "acyl-CoA:(acceptor) 2,3-oxidoreductase activity", "acyl-CoA dehydrogenase activity", "general acyl CoA dehydrogenase activity", "acyl CoA dehydrogenase activity", "acyl-CoA reductase activity", "medium-chain acyl-coenzyme A dehydrogenase activity", "fatty acyl coenzyme A dehydrogenase activity", "acyl coenzyme A dehydrogenase activity", "acyl-CoA:acceptor 2,3-oxidoreductase activity", "fatty-acyl-CoA dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. [EC:1.3.99.3]", "canonical_name": "long-chain acyl coenzyme A dehydrogenase activity"}
{"concept_id": "C1151744", "aliases": ["2-methylbutanoyl-CoA:acceptor oxidoreductase activity", "2-methylacyl-CoA dehydrogenase activity", "2-methyl branched chain acyl-CoA dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor. [EC:1.3.99.12]", "canonical_name": "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity"}
{"concept_id": "C1151745", "aliases": ["enoyl coenzyme A reductase activity", "butyryl-CoA dehydrogenase activity", "acyl-CoA dehydrogenase (NADP+) activity", "butanoyl-CoA:acceptor 2,3-oxidoreductase activity", "crotonyl coenzyme A reductase activity", "short-chain acyl CoA dehydrogenase activity", "2-enoyl-CoA reductase activity", "enoyl-coenzyme A reductase activity", "unsaturated acyl coenzyme A reductase activity", "short-chain-acyl-CoA dehydrogenase activity", "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)", "butyryl dehydrogenase activity", "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity", "ethylene reductase activity", "butyryl coenzyme A dehydrogenase activity", "acyl-CoA:NADP+ 2-oxidoreductase activity", "3-hydroxyacyl CoA reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein. [EC:1.3.8.1]", "canonical_name": "short-chain acyl-coenzyme A dehydrogenase activity"}
{"concept_id": "C1151746", "aliases": ["glutaryl coenzyme A dehydrogenase activity", "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)", "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor. [EC:1.3.8.6]", "canonical_name": "glutaryl-CoA dehydrogenase activity"}
{"concept_id": "C1151747", "aliases": ["isovaleryl-coenzyme A dehydrogenase activity", "isovaleryl-CoA dehydrogenase activity", "isovaleroyl-coenzyme A dehydrogenase activity", "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF. [EC:1.3.8.4]", "canonical_name": "3-methylbutanoyl-CoA:acceptor oxidoreductase activity"}
{"concept_id": "C1151748", "aliases": ["palmitoyl-coenzyme A dehydrogenase activity", "long-chain acyl-coenzyme A dehydrogenase activity", "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity", "palmitoyl-CoA dehydrogenase activity", "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF. [EC:1.3.8.8]", "canonical_name": "long-chain-acyl-CoA dehydrogenase activity"}
{"concept_id": "C1151749", "aliases": [], "types": ["T044"], "canonical_name": "short-branched-chain-acyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue. [GOC:mah]"}
{"concept_id": "C1151750", "aliases": ["very long-chain-acyl-CoA dehydrogenase activity"], "types": ["T044"], "canonical_name": "very-long-chain-acyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. [GOC:mah]"}
{"concept_id": "C1151752", "aliases": ["4-hydroxybenzoyl-coA reductase (dehydroxylating) activity", "4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity"], "types": ["T044"], "canonical_name": "4-hydroxybenzoyl-CoA reductase activity", "definition": "Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin. [RHEA:29603]"}
{"concept_id": "C1151753", "aliases": ["cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) activity", "benzoyl-CoA reductase (dearomatizing) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H(2)O + benzoyl-CoA + reduced ferredoxin. [EC:1.3.7.8]", "canonical_name": "benzoyl-CoA reductase activity"}
{"concept_id": "C1151754", "aliases": ["dihydoorotic acid dehydrogenase activity", "DHOdehase activity", "(S)-dihydroorotate:quinone oxidoreductase activity", "(DHO) dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. [EC:1.3.5.2, RHEA:18073]", "canonical_name": "dihydroorotate dehydrogenase activity"}
{"concept_id": "C1151755", "aliases": ["flavonoid 2-oxoglutarate-dependent dioxygenase activity", "dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity", "FLS activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O. [EC:1.14.20.6, ISBN:0943088372, PMID:7904213]", "canonical_name": "flavonol synthase activity"}
{"concept_id": "C1151756", "aliases": ["quinoline:acceptor 2-oxidoreductase (hydroxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor. [EC:1.3.99.17]", "canonical_name": "quinoline 2-oxidoreductase activity"}
{"concept_id": "C1151757", "aliases": ["fumarate dehydrogenase activity", "succinate:acceptor oxidoreductase activity", "fumarate reductase activity", "fumaric hydrogenase activity", "succinyl dehydrogenase activity", "succinate:(acceptor) oxidoreductase activity", "succinate dehydrogenase activity", "succinic acid dehydrogenase activity", "succinodehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. [GOC:kd]", "canonical_name": "succinate oxidoreductase activity"}
{"concept_id": "C1151758", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]"}
{"concept_id": "C1151759", "aliases": ["acyl-CoA oxidase activity", "acyl-CoA:oxygen 2-oxidoreductase activity", "acyl coenzyme A oxidase activity", "fatty acyl-coenzyme A oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. [EC:1.3.3.6]", "canonical_name": "fatty acyl-CoA oxidase activity"}
{"concept_id": "C1151760", "aliases": [], "types": ["T044"], "canonical_name": "palmitoyl-CoA oxidase activity", "definition": "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide. [GOC:jsg]"}
{"concept_id": "C1151761", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide. [GOC:jsg, RHEA:40459]", "canonical_name": "pristanoyl-CoA oxidase activity"}
{"concept_id": "C1151762", "aliases": ["coproporphyrinogen oxidase activity", "coproporphyrinogen III oxidase activity", "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)", "coproporphyrinogen-III oxidase activity", "coproporphyrinogenase activity", "coprogen oxidase activity", "HemN", "coproporphyrinogen dehydrogenase activity", "coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX. [EC:1.3.3.3, RHEA:18257]", "canonical_name": "oxygen-independent coproporphyrinogen-III oxidase activity"}
{"concept_id": "C1151763", "aliases": ["(S)-dihydroorotate:oxygen oxidoreductase activity", "dihydroorotate oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate. [RHEA:15441]", "canonical_name": "4,5-L-dihydroorotate:oxygen oxidoreductase activity"}
{"concept_id": "C1151764", "aliases": ["protoporphyrinogen IX oxidase activity", "protoporphyrinogen oxidase activity", "protoporphyrinogen-IX oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor. [EC:1.3.3.4, GOC:mah, PMID:19583219]", "canonical_name": "protoporphyrinogenase activity"}
{"concept_id": "C1151765", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound. [GOC:jl]"}
{"concept_id": "C1151767", "aliases": ["quinol:fumarate oxidoreductase activity", "menaquinol: fumarate oxidoreductase activity", "succinate dehydrogenase (ubiquinone) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol. [RHEA:13713]", "canonical_name": "succinate:ubiquinone oxidoreductase activity"}
{"concept_id": "C1151768", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-oxazoline dehydrogenase activity", "definition": "Catalysis of the reduction of a peptide-linked oxazoline to oxazole. [GOC:mah, PMID:19058272]"}
{"concept_id": "C1151769", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-thiazoline dehydrogenase activity", "definition": "Catalysis of the reduction of a peptide-linked thiazoline to thiazole. [GOC:mah, PMID:19058272]"}
{"concept_id": "C1151770", "aliases": [], "types": ["T044"], "canonical_name": "sterol 5-alpha reductase activity", "definition": "Catalysis of the removal of a C-5 double bond in the B ring of a sterol. [ISBN:0943088399]"}
{"concept_id": "C1151772", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH group of donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151773", "aliases": [], "types": ["T044"], "canonical_name": "iminodiacetate dehydrogenase activity", "definition": "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine. [UM-BBD_reactionID:r0589]"}
{"concept_id": "C1151774", "aliases": ["oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide. [GOC:jl]"}
{"concept_id": "C1151775", "aliases": ["pyrimidodiazepine synthase activity", "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione. [EC:1.5.4.1]", "canonical_name": "PDA synthase activity"}
{"concept_id": "C1151776", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]"}
{"concept_id": "C1151777", "aliases": ["L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity", "delta1-pyrroline-5-carboxylate dehydrogenase activity", "pyrroline-5-carboxylic acid dehydrogenase activity", "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity", "pyrroline-5-carboxylate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+). [EC:1.2.1.88]", "canonical_name": "1-pyrroline-5-carboxylate dehydrogenase activity"}
{"concept_id": "C1151778", "aliases": ["tetrahydrofolate dehydrogenase activity", "dihydrofolate reductase activity", "folic reductase activity", "dihydrofolate reduction", "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity", "thymidylate synthetase-dihydrofolate reductase activity", "dihydrofolate reductase:thymidylate synthase activity", "7,8-dihydrofolate reductase activity", "dihydrofolic acid reductase activity", "dihydrofolic reductase activity", "folic acid reductase activity", "DHFR", "pteridine reductase:dihydrofolate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. [EC:1.5.1.3]", "canonical_name": "NADPH-dihydrofolate reductase activity"}
{"concept_id": "C1151779", "aliases": ["N10-formyltetrahydrofolate dehydrogenase activity", "formyltetrahydrofolate dehydrogenase activity", "10-formyl-H2PtGlu:NADP oxidoreductase activity", "10-formyltetrahydrofolate:NADP+ oxidoreductase activity", "10-formyltetrahydrofolate dehydrogenase activity", "10-formyl-H4folate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH. [EC:1.5.1.6, RHEA:10180]", "canonical_name": "10-formyl tetrahydrofolate:NADP oxidoreductase activity"}
{"concept_id": "C1151781", "aliases": ["methylenetetrahydrofolate dehydrogenase (NAD+) activity", "5,10-methylenetetrahydrofolate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH. [EC:1.5.1.15, RHEA:22892]", "canonical_name": "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase"}
{"concept_id": "C1151782", "aliases": ["5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity", "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH. [EC:1.5.1.5, RHEA:22812]", "canonical_name": "methylenetetrahydrofolate dehydrogenase (NADP+) activity"}
{"concept_id": "C1151783", "aliases": ["5,10-methylenetetrahydrofolate reductase (FADH) activity", "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "5-methyltetrahydrofolate:NAD oxidoreductase activity", "5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "methylenetetrahydrofolate reductase (NAD(P)H) activity", "5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "N5,N10-methylenetetrahydrofolate reductase activity", "N5,10-methylenetetrahydrofolate reductase activity", "5,10-CH2-H4folate reductase activity", "5,10-methylenetetrahydropteroylglutamate reductase activity", "5,10-CH(2)-H(4)folate reductase activity", "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity", "methylenetetrahydrofolate reductase NADPH activity", "5,10-methylenetetrahydrofolate reductase (FADH2) activity", "5,10-methylenetetrahydrofolate reductase (NADPH) activity", "methylenetetrahydrofolate reductase (NADPH(2)) activity", "5,10-methylenetetrahydrofolate reductase activity", "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "methylenetetrahydrofolate reductase (NADPH2)"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. [EC:1.5.1.20, PMID:26872964]", "canonical_name": "MetF"}
{"concept_id": "C1151784", "aliases": ["riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity", "riboflavin reductase (NADPH) activity", "NAD(P)H(2) dehydrogenase (FMN) activity", "NADPH(2) dehydrogenase (FMN) activity", "NAD(P)H2 dehydrogenase (FMN)", "NADPH-riboflavin oxidoreductase activity", "SsuE", "NAD(P)H:flavin oxidoreductase activity", "FMNH2:NAD+ oxidoreductase activity", "NADPH2:FMN oxidoreductase activity", "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "NAD(P)H2:FMN oxidoreductase activity", "NADPH-dependent FMN reductase activity", "NADPH:FMN oxidoreductase activity", "NAD(P)H dehydrogenase (FMN) activity", "FMN reductase (NADH) activity", "NADPH dehydrogenase (FMN) activity", "NADPH(2):FMN oxidoreductase activity", "NAD(P)H:FMN oxidoreductase activity", "NADH:flavin oxidoreductase activity", "NADH(2) dehydrogenase (FMN) activity", "NADPH-FMN reductase activity", "NADPH2 dehydrogenase (FMN)", "NADH2:FMN oxidoreductase activity", "NADPH:riboflavin oxidoreductase activity", "FMN reductase (NADPH) activity", "FMN reductase activity", "NADPH2:riboflavin oxidoreductase activity", "NADH-FMN reductase activity", "FMNH2:NAD(P)+ oxidoreductase activity", "NADPH:flavin oxidoreductase activity", "NADH:FMN oxidoreductase activity", "NADH-dependent FMN reductase activity", "NADH dehydrogenase (FMN) activity", "NADPH dehydrogenase (riboflavin) activity", "NAD(P)H-FMN reductase activity", "NADH(2):FMN oxidoreductase activity", "NAD(P)H-dependent FMN reductase activity", "NADPH-riboflavin reductase activity", "FMNH2:NADP+ oxidoreductase activity", "NADPH2 dehydrogenase (riboflavin)", "flavin mononucleotide reductase activity", "reduced-riboflavin:NADP+ oxidoreductase activity", "flavine mononucleotide reductase activity", "NADH2 dehydrogenase (FMN)"], "types": ["T044"], "definition": "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. [EC:1.5.1.39]", "canonical_name": "NAD(P)H(2):FMN oxidoreductase activity"}
{"concept_id": "C1151785", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate. [UM-BBD_reactionID:r0587]", "canonical_name": "nitrilotriacetate monooxygenase activity"}
{"concept_id": "C1151786", "aliases": ["L-proline-NAD(P)+ 5-oxidoreductase activity", "NADPH-L-delta1-pyrroline carboxylic acid reductase activity", "L-proline oxidase activity", "P5CR activity", "L-proline:NAD(P)+ 5-oxidoreductase activity", "1-pyrroline-5-carboxylate reductase activity"], "types": ["T044"], "canonical_name": "pyrroline-5-carboxylate reductase activity", "definition": "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. [EC:1.5.1.2]"}
{"concept_id": "C1151787", "aliases": ["lysine-ketoglutarate reductase activity", "lysine-2-oxoglutarate reductase activity"], "types": ["T044"], "canonical_name": "saccharopine dehydrogenase activity", "definition": "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor. [GOC:mah]"}
{"concept_id": "C1151788", "aliases": ["epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)", "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)", "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)", "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)", "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)"], "types": ["T044"], "canonical_name": "saccharopine dehydrogenase (NAD+, L-lysine-forming) activity", "definition": "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH. [EC:1.5.1.7, RHEA:12440]"}
{"concept_id": "C1151789", "aliases": ["saccharopine reductase activity", "aminoadipate semialdehyde-glutamate reductase activity", "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity", "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)", "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)", "aminoadipic semialdehyde-glutamate reductase activity", "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)", "aminoadipic semialdehyde-glutamic reductase activity"], "types": ["T044"], "canonical_name": "saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity", "definition": "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH. [EC:1.5.1.10, RHEA:10020]"}
{"concept_id": "C1151790", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin. [GOC:jl]"}
{"concept_id": "C1151791", "aliases": ["5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity", "N(5),N(10)-methylenetetrahydromethanopterin reductase activity", "methylene-H4MPT reductase activity", "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity", "methylene-H(4)MPT reductase activity", "N5,N10-methylenetetrahydromethanopterin reductase activity", "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity", "5,10-methylenetetrahydromethanopterin cyclohydrolase activity", "5,10-methylenetetrahydromethanopterin reductase activity", "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity", "methylenetetrahydromethanopterin reductase activity"], "types": ["T044"], "canonical_name": "coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity", "definition": "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420. [EC:1.5.98.2, RHEA:21144]"}
{"concept_id": "C1151792", "aliases": ["6-N-dimethylallyladenine:acceptor oxidoreductase activity", "N6-dimethylallyladenine:(acceptor) oxidoreductase activity", "N6-dimethylallyladenine:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "cytokinin dehydrogenase activity", "definition": "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. [EC:1.5.99.12]"}
{"concept_id": "C1151794", "aliases": ["methylenetetrahydromethanopterin dehydrogenase activity", "5,10-methylenetetrahydromethanopterin dehydrogenase activity", "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420. [EC:1.5.98.1, RHEA:16721]", "canonical_name": "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity"}
{"concept_id": "C1151795", "aliases": ["D-nicotine oxidase activity", "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)", "nicotine dehydrogenase activity", "nicotine oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor. [EC:1.5.99.4]", "canonical_name": "nicotine:acceptor 6-oxidoreductase (hydroxylating)"}
{"concept_id": "C1151796", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate. [UM-BBD_reactionID:r0588]", "canonical_name": "nitrilotriacetate dehydrogenase activity"}
{"concept_id": "C1151797", "aliases": ["L-proline:(acceptor) oxidoreductase activity", "proline dehydrogenase activity", "L-proline dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. [EC:1.5.99.8]", "canonical_name": "L-proline:acceptor oxidoreductase activity"}
{"concept_id": "C1151798", "aliases": ["sarcosine:acceptor oxidoreductase (demethylating)", "sarcosine dehydrogenase activity", "sarcosine N-demethylase activity", "monomethylglycine dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein. [EC:1.5.8.3, RHEA:19793]", "canonical_name": "sarcosine:(acceptor) oxidoreductase (demethylating)"}
{"concept_id": "C1151799", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]"}
{"concept_id": "C1151800", "aliases": [], "types": ["T044"], "canonical_name": "cytokinin oxidase activity"}
{"concept_id": "C1151801", "aliases": [], "types": ["T044"], "canonical_name": "hydroxy-nicotine oxidase activity", "definition": "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide. [GOC:jl, http://umbbd.ahc.umn.edu/]"}
{"concept_id": "C1151802", "aliases": ["D-6-hydroxynicotine oxidase activity", "(R)-6-hydroxynicotine:oxygen oxidoreductase activity", "6-hydroxy-D-nicotine oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2). [EC:1.5.3.6, RHEA:10012]", "canonical_name": "(R)-6-hydroxynicotine oxidase activity"}
{"concept_id": "C1151803", "aliases": ["6-hydroxy-L-nicotine oxidase activity", "L-6-hydroxynicotine oxidase activity", "6-hydroxy-L-nicotine:oxygen oxidoreductase activity", "(S)-6-hydroxynicotine oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2). [EC:1.5.3.5, RHEA:11880]", "canonical_name": "(S)-6-hydroxynicotine:oxygen oxidoreductase activity"}
{"concept_id": "C1151804", "aliases": ["1-N-acetylspermidine:oxygen oxidoreductase (deaminating)", "N1-acetylspermidine:oxygen oxidoreductase (deaminating)"], "types": ["T044"], "definition": "Catalysis of the oxidative degradation or interconversion of polyamines. [PMID:1567380]", "canonical_name": "polyamine oxidase activity"}
{"concept_id": "C1151805", "aliases": ["sarcosine oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2). [EC:1.5.3.1, RHEA:13313]", "canonical_name": "sarcosine:oxygen oxidoreductase (demethylating)"}
{"concept_id": "C1151806", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound. [GOC:jl]"}
{"concept_id": "C1151807", "aliases": ["electron-transferring-flavoprotein:ubiquinone oxidoreductase activity", "electron transfer flavoprotein Q oxidoreductase activity", "ETF-QO activity", "ETF-ubiquinone oxidoreductase activity", "ETF dehydrogenase activity", "electron transfer flavoprotein-ubiquinone oxidoreductase activity", "electron-transferring-flavoprotein dehydrogenase activity", "electron transfer flavoprotein reductase activity", "electron transfer flavoprotein dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]. [RHEA:24052]", "canonical_name": "ETF:ubiquinone oxidoreductase activity"}
{"concept_id": "C1151808", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH2 group of donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C1151809", "aliases": [], "types": ["T044"], "canonical_name": "2-aminobenzoyl-CoA reductase activity", "definition": "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA. [UM-BBD_reactionID:r0342]"}
{"concept_id": "C1151810", "aliases": ["alpha-alanine dehydrogenase activity", "L-alanine:NAD+ oxidoreductase (deaminating)", "alanine oxidoreductase activity", "NAD-dependent alanine dehydrogenase activity", "alanine dehydrogenase activity", "NADH-dependent alanine dehydrogenase activity", "L-alanine dehydrogenase activity", "AlaDH"], "types": ["T044"], "definition": "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+). [EC:1.4.1.1]", "canonical_name": "NAD-linked alanine dehydrogenase activity"}
{"concept_id": "C1151811", "aliases": [], "types": ["T044"], "definition": "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. [EC:1.4.-.-]", "canonical_name": "glutamate synthase activity"}
{"concept_id": "C1151812", "aliases": ["glutamate synthase (ferredoxin-dependent)", "ferredoxin-glutamate synthase activity", "glutamate synthase (ferredoxin) activity", "L-glutamate:ferredoxin oxidoreductase (transaminating)"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. [EC:1.4.7.1]", "canonical_name": "ferredoxin-dependent glutamate synthase activity"}
{"concept_id": "C1151813", "aliases": [], "types": ["T044"], "canonical_name": "glutamate synthase activity, NADH or NADPH as acceptor"}
{"concept_id": "C1151814", "aliases": ["L-glutamate synthase activity", "L-glutamate:NAD+ oxidoreductase (transaminating)", "NADH: GOGAT", "glutamate (reduced nicotinamide adenine dinucleotide) synthase", "glutamate synthase (NADH) activity", "NADH-glutamate synthase activity", "L-glutamate synthase (NADH)"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH. [EC:1.4.1.14, RHEA:13753]", "canonical_name": "NADH-dependent glutamate synthase activity"}
{"concept_id": "C1151815", "aliases": ["L-glutamate:NADP+ oxidoreductase (transaminating)", "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity", "glutamate synthase (NADPH) activity", "GOGAT activity", "NADPH-linked glutamate synthase", "NADPH-glutamate synthase activity", "glutamine-ketoglutaric aminotransferase activity", "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity", "NADPH-dependent glutamate synthase activity", "NADPH GOGAT", "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+. [EC:1.4.1.13, RHEA:15501]", "canonical_name": "glutamate synthetase (NADP) activity"}
{"concept_id": "C1151816", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule. [GOC:ai]"}
{"concept_id": "C1151817", "aliases": ["oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group. [GOC:ai]"}
{"concept_id": "C1151818", "aliases": ["protein P1", "glycine decarboxylase activity", "P-protein", "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)", "glycine-cleavage complex P-protein activity", "glycine cleavage system P-protein activity", "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)", "glycine dehydrogenase (decarboxylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. [EC:1.4.4.2]", "canonical_name": "glycine-cleavage complex"}
{"concept_id": "C1151819", "aliases": ["oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:ai]"}
{"concept_id": "C1151820", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. [GOC:ai]"}
{"concept_id": "C1151821", "aliases": ["glutamate dehydrogenase (NAD)", "NAD:glutamate oxidoreductase activity", "NAD-specific glutamate dehydrogenase activity", "NAD-linked glutamate dehydrogenase activity", "NAD-glutamate dehydrogenase activity", "NADH-linked glutamate dehydrogenase activity", "glutamate oxidoreductase activity", "NAD-linked glutamic dehydrogenase activity", "glutamate dehydrogenase (NAD+) activity", "NAD-specific glutamic dehydrogenase activity", "NAD-dependent glutamate dehydrogenase activity", "NAD-dependent glutamic dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. [EC:1.4.1.2]", "canonical_name": "L-glutamate:NAD+ oxidoreductase (deaminating)"}
{"concept_id": "C1151822", "aliases": ["glutamate dehydrogenase [NAD(P)+] activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+. [EC:1.4.1.3]", "canonical_name": "L-glutamate:NAD(P)+ oxidoreductase (deaminating)"}
{"concept_id": "C1151823", "aliases": ["NAD(P)H-dependent glutamate dehydrogenase activity", "L-glutamic acid dehydrogenase activity", "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))", "glutamate dehydrogenase (NADP+) activity", "L-glutamate:NADP+ oxidoreductase (deaminating)"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. [EC:1.4.1.4]", "canonical_name": "NAD(P)-glutamate dehydrogenase activity"}
{"concept_id": "C1151824", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen. [GOC:ai]"}
{"concept_id": "C1151825", "aliases": ["primary-amine:acceptor oxidoreductase (deaminating)", "amine: (acceptor) oxidoreductase (deaminating)", "MADH activity", "amine dehydrogenase"], "types": ["T044"], "definition": "Catalysis of the reaction: an aliphatic amine + an acceptor (A) + H2O = an aldehyde + a reduced acceptor (AH2) + NH4+. [PMID:6246962, RHEA:51128]", "canonical_name": "amine dehydrogenase activity"}
{"concept_id": "C1151826", "aliases": ["aromatic amine dehydrogenase (azurin) activity", "aralkylamine dehydrogenase (azurin) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced [azurin]. [PMID:10506161, RHEA:47796]", "canonical_name": "aralkylamine:(azurin) oxidoreductase (deaminating) activity"}
{"concept_id": "C1151827", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. [GOC:ai]"}
{"concept_id": "C1151828", "aliases": ["1-aminocyclopropane-1-carboxylate oxidase activity", "ACC oxidase activity", "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O(2) = CO(2) + dehydroascorbate + ethylene + 2 H(2)O + hydrogen cyanide. Ethene is also known as ethylene. [EC:1.14.17.4, RHEA:23640]", "canonical_name": "aminocyclopropanecarboxylate oxidase activity"}
{"concept_id": "C1151830", "aliases": ["primary amine oxidase activity", "primary-amine:oxygen oxidoreductase (deaminating) activity", "amine oxidase (copper-containing) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. [EC:1.4.3.21]", "canonical_name": "amine oxidase activity"}
{"concept_id": "C1151832", "aliases": [], "types": ["T044"], "canonical_name": "aspartate oxidase activity", "definition": "Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide. [EC:1.4.3.1, EC:1.4.3.16]"}
{"concept_id": "C1151833", "aliases": ["D-aspartate oxidase activity", "aspartic oxidase activity", "D-aspartic oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide. [EC:1.4.3.1]", "canonical_name": "D-aspartate:oxygen oxidoreductase (deaminating)"}
{"concept_id": "C1151834", "aliases": ["L-aspartate:oxygen oxidoreductase"], "types": ["T044"], "definition": "Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide. [EC:1.4.3.16]", "canonical_name": "L-aspartate oxidase activity"}
{"concept_id": "C1151835", "aliases": ["cyclohexylamine oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide. [EC:1.4.3.12]", "canonical_name": "cyclohexylamine:oxygen oxidoreductase (deaminating)"}
{"concept_id": "C1151836", "aliases": ["D-amino-acid dehydrogenase activity", "D-amino-acid:(acceptor) oxidoreductase (deaminating)"], "types": ["T044"], "definition": "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. [RHEA:18125]", "canonical_name": "D-amino-acid:acceptor oxidoreductase (deaminating)"}
{"concept_id": "C1151837", "aliases": ["D-amino-acid oxidase activity", "L-amino acid:O2 oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. [EC:1.4.3.3]", "canonical_name": "D-amino-acid:oxygen oxidoreductase (deaminating)"}
{"concept_id": "C1151838", "aliases": ["ophio-amino-acid oxidase activity", "L-amino-acid:oxygen oxidoreductase (deaminating)"], "types": ["T044"], "definition": "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. [EC:1.4.3.2]", "canonical_name": "L-amino-acid oxidase activity"}
{"concept_id": "C1151839", "aliases": ["protein-L-lysine:oxygen 6-oxidoreductase (deaminating)", "protein-lysine 6-oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide. [EC:1.4.3.13]", "canonical_name": "lysyl oxidase activity"}
{"concept_id": "C1151840", "aliases": ["PMP oxidase activity", "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity", "pyridoxal 5'-phosphate synthase activity", "pyridoxine (pyridoxamine)phosphate oxidase activity", "pyridoxamine phosphate oxidase activity", "PdxH", "pyridoxamine 5'-phosphate oxidase activity", "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)", "pyridoxamine-phosphate oxidase activity", "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)"], "types": ["T044"], "definition": "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide. [EC:1.4.3.5]", "canonical_name": "pyridoxaminephosphate oxidase deaminating"}
{"concept_id": "C1151841", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, oxidizing metal ions"}
{"concept_id": "C1151842", "aliases": ["arsenate reductase (azurin) activity", "arsenite oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + arsenite + 2 oxidized azurin = 2 H(+) + 2 reduced azurin + arsenate. [EC:1.20.9.1, MetaCyc:1.20.98.1-RXN]", "canonical_name": "arsenite:azurin oxidoreductase activity"}
{"concept_id": "C1151843", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor"}
{"concept_id": "C1151844", "aliases": [], "types": ["T044"], "canonical_name": "cupric reductase activity", "definition": "Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH. [PMID:10510271]"}
{"concept_id": "C1151845", "aliases": ["mercurate(II) reductase activity", "mercury (II) reductase activity", "Hg:NADP+ oxidoreductase activity", "mercury reductase activity", "mercury(II) reductase activity", "mercuric reductase activity", "reduced NADP:mercuric ion oxidoreductase activity", "mer A"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH. [RHEA:23856]", "canonical_name": "mercuric ion reductase activity"}
{"concept_id": "C1151846", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, oxidizing metal ions, oxygen as acceptor"}
{"concept_id": "C1151847", "aliases": ["caeruloplasmin", "iron(II): oxygen oxidoreductase activity", "HEPH", "ferroxidase, iron II:oxygen oxidoreductase activity", "Fe(II):oxygen oxidoreductase activity", "ferro:O2 oxidoreductase activity", "ceruloplasmin"], "types": ["T044"], "definition": "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. [RHEA:11148]", "canonical_name": "ferroxidase activity"}
{"concept_id": "C1151848", "aliases": ["multicopper ferroxidase iron transport mediator activity"], "types": ["T044"], "canonical_name": "multicopper ferroxidase iron transport mediator activity", "definition": "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. [EC:1.16.3.1]"}
{"concept_id": "C1151849", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems. [PMID:7589982]", "canonical_name": "phthalate dioxygenase reductase activity"}
{"concept_id": "C1151850", "aliases": [], "types": ["T044"], "definition": "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene. [PMID:29176862]", "canonical_name": "phytoene dehydrogenase activity"}
{"concept_id": "C1151851", "aliases": [], "types": ["T044"], "canonical_name": "sphingosine hydroxylase activity", "definition": "Catalysis of the hydroxylation of sphingolipid long chain bases. [PMID:9556590]"}
{"concept_id": "C1151852", "aliases": ["sulfhydryl oxidase activity", "thiol:oxygen oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O2. [RHEA:17357]", "canonical_name": "thiol oxidase activity"}
{"concept_id": "C1151853", "aliases": [], "types": ["T044"], "canonical_name": "flavin-linked sulfhydryl oxidase activity", "definition": "Catalysis of the formation of disulfide bridges in proteins using FAD as the electron acceptor. [PMID:10899311]"}
{"concept_id": "C1151854", "aliases": [], "types": ["T044"], "canonical_name": "tetrahydrothiophene 1-oxide reductase activity", "definition": "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor. [MetaCyc:THTOREDUCT-RXN]"}
{"concept_id": "C1151855", "aliases": ["tRNA-(ms2io6A)-hydroxylase activity", "2-methylthio-cis-ribozeatin hydroxylase activity", "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity"], "types": ["T045"], "canonical_name": "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity", "definition": "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin. [GOC:mlg, PMID:8253666]"}
{"concept_id": "C1151856", "aliases": [], "types": ["T044"], "canonical_name": "tyramine-beta hydroxylase activity", "definition": "Catalysis of the hydroxylation of tyramine to form octopamine. [PMID:10745161]"}
{"concept_id": "C1151857", "aliases": ["violaxanthin de-epoxidase activity", "violaxanthin:ascorbate oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O. [EC:1.23.5.1, GOC:ai, ISBN:0471331309]", "canonical_name": "VDE"}
{"concept_id": "C1151858", "aliases": ["vitamin D3 25-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O. [ISBN:0471331309, MetaCyc:RXN-9829]", "canonical_name": "cholecalciferol 25-hydroxylase activity"}
{"concept_id": "C1151862", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate phosphatase activity", "definition": "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. [GOC:mah]"}
{"concept_id": "C1151865", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. [EC:3.2.1.143]", "canonical_name": "poly(ADP-ribose) glycohydrolase activity"}
{"concept_id": "C1151869", "aliases": [], "types": ["T045"], "canonical_name": "double-stranded RNA specific editase activity"}
{"concept_id": "C1151870", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "siroheme synthase activity"}
{"concept_id": "C1151871", "aliases": [], "types": ["T044"], "canonical_name": "small protein activating enzyme activity"}
{"concept_id": "C1151872", "aliases": ["ubiquitin activating enzyme activity"], "types": ["T044"], "definition": "Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. [GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme]", "canonical_name": "E1 ubiquitin-activating enzyme"}
{"concept_id": "C1151874", "aliases": [], "types": ["T044"], "canonical_name": "APG12 activating enzyme activity"}
{"concept_id": "C1151875", "aliases": ["APG8 activating enzyme activity", "APG7"], "types": ["T044"], "definition": "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:mah]", "canonical_name": "Atg8 activating enzyme activity"}
{"concept_id": "C1151876", "aliases": [], "types": ["T044"], "canonical_name": "FAT10 activating enzyme activity", "definition": "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:mah]"}
{"concept_id": "C1151877", "aliases": [], "types": ["T044"], "canonical_name": "Hub1 activating enzyme activity", "definition": "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:mah]"}
{"concept_id": "C1151879", "aliases": ["RUB1 activating enzyme activity"], "types": ["T044"], "canonical_name": "NEDD8 activating enzyme activity", "definition": "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade. [PMID:12646924]"}
{"concept_id": "C1151880", "aliases": ["SMT3 activating enzyme", "SUMO E1 activator enzyme"], "types": ["T044"], "canonical_name": "SUMO activating enzyme activity", "definition": "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:rn, PMID:10187858, PMID:11265250]"}
{"concept_id": "C1151881", "aliases": [], "types": ["T044"], "canonical_name": "URM1 activating enzyme activity", "definition": "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:mah]"}
{"concept_id": "C1151883", "aliases": ["ubiquitin-conjugating enzyme activity", "ubiquitin conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. [GOC:BioGRID, GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C1151884", "aliases": ["ubiquitin-like conjugating enzyme activity", "ubiquitin-like protein conjugating enzyme activity", "small conjugating protein conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C1151885", "aliases": ["Atg12 ligase activity", "APG12 ligase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S --> X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "canonical_name": "E3"}
{"concept_id": "C1151886", "aliases": ["APG8 conjugating enzyme activity", "Atg8 conjugating enzyme activity", "APG8 ligase activity"], "types": ["T044"], "canonical_name": "Atg8 ligase activity", "definition": "Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate. [GOC:mah, PMID:12826404]"}
{"concept_id": "C1151887", "aliases": ["FAT10 conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y -> Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C1151892", "aliases": [], "types": ["T044"], "canonical_name": "URM1 transferase activity", "definition": "Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y --> Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages. [GOC:mah, PMID:12826404]"}
{"concept_id": "C1151893", "aliases": ["delta-4 sphingolipid desaturase activity"], "types": ["T044"], "canonical_name": "sphingolipid delta-4 desaturase activity", "definition": "Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O. [PMID:12417141, RHEA:46544]"}
{"concept_id": "C1151894", "aliases": [], "types": ["T044"], "canonical_name": "sterol carrier protein X-related thiolase activity"}
{"concept_id": "C1151895", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. [ISBN:0198506732]", "canonical_name": "transferase activity"}
{"concept_id": "C1151897", "aliases": [], "types": ["T044"], "canonical_name": "CDP-alcohol phosphotransferase activity", "definition": "Catalysis of the transfer of a CDP-alcohol group from one compound to another. [GOC:jl]"}
{"concept_id": "C1151898", "aliases": ["AdoCbi kinase/AdoCbi-phosphate guanylyltransferase", "adenosylcobinamide-phosphate guanylyltransferase activity", "GTP:cobinamide phosphate guanylyltransferase activity", "cobinamide phosphate guanylyltransferase activity", "CobU", "GTP:adenosylcobinamide-phosphate guanylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H(+) = adenosylcobinamide-GDP + diphosphate. [EC:2.7.7.62, RHEA:22712]", "canonical_name": "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase"}
{"concept_id": "C1151899", "aliases": [], "types": ["T044"], "canonical_name": "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1151900", "aliases": [], "types": ["T044"], "canonical_name": "glucanosyltransferase activity", "definition": "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation. [GOC:jl]"}
{"concept_id": "C1151901", "aliases": [], "types": ["T044"], "definition": "Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation. [GOC:jl, PMID:10809732]", "canonical_name": "1,3-beta-glucanosyltransferase activity"}
{"concept_id": "C1151902", "aliases": ["lauroyl transferase activity"], "types": ["T044"], "canonical_name": "lauroyltransferase activity", "definition": "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1151903", "aliases": [], "types": ["T044"], "canonical_name": "lipoyltransferase activity", "definition": "Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N6-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H+. [PMID:10103005, RHEA:20473]"}
{"concept_id": "C1151904", "aliases": [], "types": ["T044"], "canonical_name": "mannosylphosphate transferase activity", "definition": "Catalysis of the transfer of a mannosylphosphate group from one compound to another. [GOC:jl]"}
{"concept_id": "C1151907", "aliases": ["transferase activity, transferring amino-acyl groups"], "types": ["T044"], "definition": "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). [GOC:jl]", "canonical_name": "aminoacyltransferase activity"}
{"concept_id": "C1151909", "aliases": ["arginyltransferase activity", "arginyl-tRNA protein transferase activity", "L-arginyl-tRNA:protein arginyltransferase activity", "arginyl-transfer ribonucleate-protein transferase activity", "arginyl-transfer ribonucleate-protein aminoacyltransferase activity", "arginyl-tRNA-protein transferase activity", "arginine transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein. [EC:2.3.2.8]", "canonical_name": "arginyl-tRNA--protein transferase activity"}
{"concept_id": "C1151911", "aliases": ["gamma-glutamyl-amino acid cyclotransferase activity", "L-glutamic cyclase activity", "gamma-glutamylcyclotransferase activity", "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)"], "types": ["T044"], "definition": "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. [PMID:18515354]", "canonical_name": "gamma-L-glutamylcyclotransferase activity"}
{"concept_id": "C1151912", "aliases": ["glutaminyl-transfer ribonucleate cyclotransferase activity", "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)", "glutaminyl cyclase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3. [EC:2.3.2.5]", "canonical_name": "glutaminyl-peptide cyclotransferase activity"}
{"concept_id": "C1151913", "aliases": ["phytochelatin synthase activity", "gamma-glutamylcysteine dipeptidyl transpeptidase activity", "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly. [EC:2.3.2.15]", "canonical_name": "glutathione gamma-glutamylcysteinyltransferase activity"}
{"concept_id": "C1151914", "aliases": ["leucyl, phenylalanine-tRNA-protein transferase activity", "L/F transferase activity", "L-leucyl-tRNA:protein leucyltransferase activity", "leucyl/phenylalanyl-tRNA--protein transferase activity", "leucyl-tRNA--protein transferase activity", "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity", "leucyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein. [EC:2.3.2.6]", "canonical_name": "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity"}
{"concept_id": "C1151915", "aliases": ["peptidyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). [PMID:11433365, PMID:9242921]", "canonical_name": "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity"}
{"concept_id": "C1151916", "aliases": ["transferase activity, transferring acyl groups other than amino-acyl groups", "transferase activity, transferring groups other than amino-acyl groups"], "types": ["T044"], "canonical_name": "acyltransferase activity, transferring groups other than amino-acyl groups", "definition": "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). [GOC:jl]"}
{"concept_id": "C1151917", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxybutyryl-CoA thiolase activity", "definition": "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA. [UM-BBD_reactionID:r0010]"}
{"concept_id": "C1151918", "aliases": [], "types": ["T044"], "canonical_name": "3-ketopimelyl-CoA thiolase activity", "definition": "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA. [UM-BBD_reactionID:r0197]"}
{"concept_id": "C1151919", "aliases": ["alpha-aminolevulinic acid synthase activity", "5-aminolevulinic acid synthetase activity", "delta-ALA synthetase activity", "aminolevulinic acid synthase activity", "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)", "delta-aminolevulinic acid synthetase activity", "delta-aminolevulinate synthase activity", "aminolevulinate synthase activity", "delta-aminolevulinic synthetase activity", "delta-aminolevulinic acid synthase activity", "aminolevulinate synthetase activity", "5-aminolevulinate synthetase activity", "ALAS activity", "delta-aminolevulinate synthetase activity", "5-aminolevulinate synthase activity", "aminolevulinic synthetase activity", "aminolevulinic acid synthetase activity", "ALA synthetase activity", "ALA synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA. [EC:2.3.1.37, RHEA:12921]", "canonical_name": "5-aminolevulinic acid synthase activity"}
{"concept_id": "C1151920", "aliases": ["6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)", "8-amino-7-ketopelargonate synthase activity", "7-keto-8-aminopelargonic acid synthetase activity", "8-amino-7-oxopelargonate synthase activity", "AONS activity", "7-keto-8-aminopelargonic synthetase activity", "7-KAP synthetase activity", "8-amino-7-oxononanoate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-alanine + H(+) + pimelyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA. [EC:2.3.1.47, RHEA:20712]", "canonical_name": "7-keto-8-amino-pelargonic acid synthetase activity"}
{"concept_id": "C1151921", "aliases": ["acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]", "canonical_name": "transferase activity, transferring acyl groups"}
{"concept_id": "C1151922", "aliases": ["acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of an acetyl group to an acceptor molecule. [GOC:ai]", "canonical_name": "acetylase activity"}
{"concept_id": "C1151923", "aliases": [], "types": ["T044"], "canonical_name": "C-acetyltransferase activity", "definition": "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151924", "aliases": ["acetoacetyl-CoA thiolase activity", "acetyl-CoA:N-acetyltransferase activity", "acetyl-CoA acetyltransferase activity", "acetyl-CoA:acetyl-CoA C-acetyltransferase activity", "3-oxothiolase activity", "acetyl coenzyme A thiolase activity", "acetyl-CoA C-acetyltransferase activity", "beta-acetoacetyl coenzyme A thiolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. [EC:2.3.1.9]", "canonical_name": "2-methylacetoacetyl-CoA thiolase"}
{"concept_id": "C1151925", "aliases": ["pyruvate formate:lyase activity", "acetyl-CoA:formate C-acetyltransferase activity", "formate C-acetyltransferase activity", "pyruvic formate-lyase activity", "PFL", "pyruvate formate-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate. [RHEA:11844]", "canonical_name": "formate acetyltransferase activity"}
{"concept_id": "C1151926", "aliases": ["2-amino-3-ketobutyrate CoA ligase activity", "2-amino-3-ketobutyrate coenzyme A ligase activity", "2-amino-3-ketobutyrate-CoA ligase activity", "aminoacetone synthase activity", "acetyl-CoA:glycine C-acetyltransferase activity", "glycine acetyltransferase activity"], "types": ["T044"], "canonical_name": "glycine C-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+). [EC:2.3.1.29, RHEA:20736]"}
{"concept_id": "C1151927", "aliases": ["thymidine diphosphoaminodideoxygalactose aminotransferase activity", "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity", "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity", "dTDP-fucosamine aminotransferase activity", "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity"], "types": ["T044"], "canonical_name": "dTDP-4-amino-4,6-dideoxygalactose transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose. [EC:2.6.1.59, RHEA:10368]"}
{"concept_id": "C1151928", "aliases": ["histone acetokinase activity", "histone transacetylase activity", "histone lysine acetyltransferase activity", "histone acetyltransferase activity", "acetyl-CoA:histone acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. [EC:2.3.1.48]", "canonical_name": "histone acetylase activity"}
{"concept_id": "C1151929", "aliases": [], "types": ["T044"], "canonical_name": "H2A/H2B histone acetyltransferase activity"}
{"concept_id": "C1151930", "aliases": [], "types": ["T044"], "canonical_name": "H3/H4 histone acetyltransferase activity"}
{"concept_id": "C1151931", "aliases": ["LAT activity", "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity", "lysine acetyltransferase activity", "lysine N(6)-acetyltransferase activity", "lysine N6-acetyltransferase activity", "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine. [EC:2.3.1.32]", "canonical_name": "acetyl-phosphate:L-lysine N6-acetyltransferase activity"}
{"concept_id": "C1151932", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. [GOC:ai]", "canonical_name": "N-acetyltransferase activity"}
{"concept_id": "C1151934", "aliases": ["acetyl-CoA:2-arylethylamine N-acetyltransferase activity", "AANAT activity", "arylalkylamine N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "aralkylamine N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine. [EC:2.3.1.87]"}
{"concept_id": "C1151935", "aliases": ["4-aminobiphenyl N-acetyltransferase activity", "beta-naphthylamine N-acetyltransferase activity", "p-aminosalicylate N-acetyltransferase activity", "acetyl-CoA:arylamine N-acetyltransferase activity", "acetyl CoA-arylamine N-acetyltransferase activity", "arylamine N-acetyltransferase activity", "indoleamine N-acetyltransferase activity", "arylamine acetyltransferase activity", "2-naphthylamine N-acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. [EC:2.3.1.5]", "canonical_name": "arylamine acetylase activity"}
{"concept_id": "C1151936", "aliases": ["aspartate N-acetyltransferase activity", "acetyl-CoA:L-aspartate N-acetyltransferase activity", "L-aspartate N-acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+). [EC:2.3.1.17, RHEA:14165]", "canonical_name": "aspartate acetyltransferase activity"}
{"concept_id": "C1151937", "aliases": ["spermidine N1-acetyltransferase activity", "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity", "spermidine/spermine N1-acetyltransferase activity", "diamine acetyltransferase activity"], "types": ["T044"], "canonical_name": "diamine N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. [EC:2.3.1.57]"}
{"concept_id": "C1151938", "aliases": ["gentamicin 3'-N-acetyltransferase activity", "acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity", "gentamycin 3'-N-acetyltransferase activity", "3-N-aminoglycoside acetyltransferase activity", "gentamicin-(3)-N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "aminoglycoside 3-N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring. [GOC:cb]"}
{"concept_id": "C1151939", "aliases": ["acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity", "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "glucosamine-1-phosphate N-acetyltransferase activity", "definition": "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+). [EC:2.3.1.157, RHEA:13725]"}
{"concept_id": "C1151940", "aliases": ["acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity", "glucosamine 6-phosphate acetylase activity", "glucosamine-6-phosphate acetylase activity", "phosphoglucosamine acetylase activity", "N-acetylglucosamine-6-phosphate synthase activity", "phosphoglucosamine N-acetylase activity", "phosphoglucosamine transacetylase activity", "glucosamine-phosphate N-acetyltransferase activity", "aminodeoxyglucosephosphate acetyltransferase activity", "D-glucosamine-6-P N-acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+). [EC:2.3.1.4, RHEA:10292]", "canonical_name": "glucosamine 6-phosphate N-acetyltransferase activity"}
{"concept_id": "C1151941", "aliases": ["acetylglutamic-acetylornithine transacetylase activity", "ornithine transacetylase activity", "acetylglutamate synthetase activity", "acetylglutamic synthetase activity", "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity", "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity", "glutamate acetyltransferase activity", "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity", "acetylornithine glutamate acetyltransferase activity", "acetylglutamate-acetylornithine transacetylase activity", "ornithine acetyltransferase activity"], "types": ["T044"], "canonical_name": "glutamate N-acetyltransferase activity", "definition": "Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine. [EC:2.3.1.35, RHEA:15349]"}
{"concept_id": "C1151942", "aliases": ["acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity", "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "heparan-alpha-glucosaminide N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide. [EC:2.3.1.78]"}
{"concept_id": "C1151943", "aliases": ["acetyl-CoA:peptide nalpha-acetyltransferase activity", "protein N-terminal acetyltransferase activity", "peptide alpha-N-acetyltransferase activity", "nalpha-acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein. [GOC:mah, PMID:30054468]", "canonical_name": "acetyl-CoA:peptide alpha-N-acetyltransferase activity"}
{"concept_id": "C1151944", "aliases": ["ribosomal-protein-alanine N-acetyltransferase activity", "ribosomal protein S18 acetyltransferase activity"], "types": ["T045"], "canonical_name": "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity"}
{"concept_id": "C1151945", "aliases": ["TAT activity", "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity", "alpha-tubulin N-acetyltransferase activity", "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity", "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity", "alpha-tubulin acetylase activity", "alpha-tubulin acetyltransferase activity", "tubulin N-acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine. [EC:2.3.1.108]", "canonical_name": "tubulin acetyltransferase activity"}
{"concept_id": "C1151946", "aliases": ["phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity", "PDAT activity"], "types": ["T044"], "canonical_name": "phospholipid:diacylglycerol acyltransferase activity", "definition": "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol. [EC:2.3.1.158]"}
{"concept_id": "C1151947", "aliases": [], "types": ["T044"], "canonical_name": "O-acetyltransferase activity", "definition": "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151948", "aliases": ["acetyl-CoA:alcohol O-acetyltransferase activity", "alcohol O-acetyltransferase activity", "alcohol acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester. [EC:2.3.1.84]", "canonical_name": "AATASE activity"}
{"concept_id": "C1151949", "aliases": ["carnitine O-acetyltransferase activity", "acetylcarnitine transferase activity", "acetyl-CoA:carnitine O-acetyltransferase activity", "acetyl-CoA-carnitine O-acetyltransferase activity", "CATC", "carnitine acetylase activity", "carnitine acetyltransferase activity", "carnitine-acetyl-CoA transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA. [EC:2.3.1.7, RHEA:21136]", "canonical_name": "carnitine acetyl coenzyme A transferase activity"}
{"concept_id": "C1151952", "aliases": ["acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity", "CAT II", "chloramphenicol transacetylase activity", "chloramphenicol O-acetyltransferase activity", "CAT III", "chloramphenicol acetylase activity", "chloramphenicol acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA. [EC:2.3.1.28, RHEA:18421]", "canonical_name": "CAT I"}
{"concept_id": "C1151953", "aliases": ["choline O-acetyltransferase activity", "choline acetyltransferase activity", "acetyl-CoA:choline O-acetyltransferase activity", "CHOACTase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. [EC:2.3.1.6, RHEA:18821]", "canonical_name": "choline acetylase activity"}
{"concept_id": "C1151954", "aliases": ["thiogalactoside acetyltransferase activity", "galactoside acetyltransferase activity", "thiogalactoside transacetylase activity", "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity"], "types": ["T044"], "canonical_name": "galactoside O-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside. [EC:2.3.1.18]"}
{"concept_id": "C1151955", "aliases": ["dihydroxyacetone phosphate acyltransferase activity", "glycerone-phosphate O-acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA. [EC:2.3.1.42, RHEA:17657]", "canonical_name": "acyl-CoA:glycerone-phosphate O-acyltransferase activity"}
{"concept_id": "C1151956", "aliases": ["L-homoserine O-acetyltransferase activity", "homoserine acetyltransferase activity", "acetyl-CoA:L-homoserine O-acetyltransferase activity", "homoserine transacetylase activity", "homoserine O-trans-acetylase activity", "homoserine-O-transacetylase activity"], "types": ["T044"], "canonical_name": "homoserine O-acetyltransferase activity", "definition": "Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA. [EC:2.3.1.31, RHEA:13701]"}
{"concept_id": "C1151957", "aliases": ["acetyl-CoA:maltose O-acetyltransferase activity", "maltose transacetylase activity"], "types": ["T044"], "canonical_name": "maltose O-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose. [EC:2.3.1.79]"}
{"concept_id": "C1151958", "aliases": ["SATase activity", "serine transacetylase activity", "acetyl-CoA:L-serine O-acetyltransferase activity", "serine acetyltransferase activity", "L-serine acetyltransferase activity"], "types": ["T044"], "canonical_name": "serine O-acetyltransferase activity", "definition": "Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. [EC:2.3.1.30, RHEA:24560]"}
{"concept_id": "C1151959", "aliases": ["phosphoacylase activity", "PTA", "acetyl-CoA:phosphate acetyltransferase activity", "phosphotransacetylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate. [EC:2.3.1.8]", "canonical_name": "phosphate acetyltransferase activity"}
{"concept_id": "C1151960", "aliases": [], "types": ["T044"], "canonical_name": "S-acetyltransferase activity", "definition": "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151961", "aliases": ["lipoic acetyltransferase activity", "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity", "dihydrolipoamide S-acetyltransferase activity", "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity", "dihydrolipoate acetyltransferase activity", "lipoate acetyltransferase activity", "dihydrolipoyl acetyltransferase activity", "lipoylacetyltransferase activity", "lipoic transacetylase activity", "lipoate transacetylase activity", "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity", "lipoic acid acetyltransferase activity", "dihydrolipoic transacetylase activity", "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity"], "types": ["T044"], "canonical_name": "dihydrolipoyllysine-residue acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. [EC:2.3.1.12]"}
{"concept_id": "C1151962", "aliases": ["acetyl coenzyme A-acyl-carrier-protein transacylase activity", "acyl-carrier-protein S-acetyltransferase activity", "[acyl-carrier protein] S-acetyltransferase activity", "acyl-carrier-proteinacetyltransferase activity", "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity", "acyl-carrier-protein acetyltransferase activity", "ACP S-acetyltransferase activity", "ACP acetyltransferase activity", "ACPacetyltransferase activity"], "types": ["T044"], "canonical_name": "[acyl-carrier-protein] S-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]. [RHEA:41788]"}
{"concept_id": "C1151963", "aliases": [], "types": ["T044"], "canonical_name": "C-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151964", "aliases": ["6-oxoacyl-CoA thiolase activity", "beta-ketoacyl-CoA thiolase activity", "beta-ketoadipyl coenzyme A thiolase activity", "beta-ketoadipyl-CoA thiolase activity", "pro-3-ketoacyl-CoA thiolase activity", "3-ketothiolase activity", "beta-ketothiolase activity", "acyl-CoA:acetyl-CoA C-acyltransferase activity", "3-oxoacyl-CoA thiolase activity", "3-ketoacyl coenzyme A thiolase activity", "oxoacyl-coenzyme A thiolase activity", "acetoacetyl-CoA beta-ketothiolase activity", "2-keto-acyl thiolase activity", "long-chain 3-oxoacyl-CoA thiolase activity", "acetyl-CoA acyltransferase activity", "3-ketoacyl CoA thiolase activity", "KAT", "3-oxoacyl-coenzyme A thiolase activity", "beta-ketoacyl coenzyme A thiolase activity", "acetyl-CoA C-acyltransferase activity", "ketoacyl-coenzyme A thiolase activity", "3-ketoacyl thiolase activity", "ketoacyl-CoA acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. [EC:2.3.1.16]", "canonical_name": "3-ketoacyl-CoA thiolase activity"}
{"concept_id": "C1151965", "aliases": [], "types": ["T044"], "canonical_name": "C-palmitoyltransferase activity", "definition": "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151966", "aliases": ["serine C-palmitoyltransferase activity", "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity", "3-oxosphinganine synthetase activity", "acyl-CoA:serine C-2 acyltransferase decarboxylating"], "types": ["T044"], "definition": "Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA. [EC:2.3.1.50, RHEA:14761]", "canonical_name": "SPT"}
{"concept_id": "C1151967", "aliases": ["lovastatin nonaketide synthase activity", "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)", "fatty acid synthase activity", "fatty-acid synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+). [EC:2.3.1.161, RHEA:18565]", "canonical_name": "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)"}
{"concept_id": "C1151968", "aliases": ["3-oxoacyl-ACP synthase activity", "beta-ketoacylsynthase activity", "beta-ketoacyl synthetase activity", "beta-ketoacyl-ACP synthetase activity", "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)", "3-ketoacyl-acyl carrier protein synthase activity", "3-oxoacyl-acyl-carrier-protein synthase activity", "acyl-malonyl acyl carrier protein-condensing enzyme activity", "ketoacyl-ACP synthase activity", "3-oxoacyl-[acyl-carrier protein] synthase activity", "beta-ketoacyl-acyl carrier protein synthetase activity", "beta-ketoacyl-[acyl carrier protein] synthase activity", "beta-ketoacyl acyl carrier protein synthase activity", "beta-ketoacyl-acyl carrier protein synthase activity", "3-oxoacyl-[acyl-carrier-protein] synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. [RHEA:22836]", "canonical_name": "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity"}
{"concept_id": "C1151969", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid elongase activity", "definition": "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C). [GOC:tb]"}
{"concept_id": "C1151970", "aliases": ["acyl-carrier-protein S-malonyltransferase activity", "acyl carrier protein malonyltransferase activity", "malonyl-CoA:acyl carrier protein transacylase activity", "FabD", "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity", "MAT", "MCAT activity", "malonyl coenzyme A-acyl carrier protein transacylase activity", "[acyl-carrier-protein] S-malonyltransferase activity", "malonyl-CoA-acyl carrier protein transacylase activity", "malonyl-CoA:AcpM transacylase activity", "ACP S-malonyltransferase activity", "acyl carrier proteinmalonyltransferase activity", "malonyl-CoA:ACP transacylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. [EC:2.3.1.39]", "canonical_name": "[acyl-carrier protein] S-malonyltransferase activity"}
{"concept_id": "C1151971", "aliases": ["glycerol phosphate acyltransferase activity", "glycerophosphate transacylase activity", "alpha-glycerophosphate acyltransferase activity", "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity", "glycerol phosphate transacylase activity", "3-glycerophosphate acyltransferase activity", "ACP:sn-glycerol-3-phosphate acyltransferase activity", "glycerophosphate acyltransferase activity", "glycerol-3-phosphate O-acyltransferase activity", "sn-glycerol-3-phosphate acyltransferase activity", "glycerol 3-phosphate acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. [EC:2.3.1.15]", "canonical_name": "sn-glycerol 3-phosphate acyltransferase activity"}
{"concept_id": "C1151972", "aliases": ["isopenicillin N:acyl-CoA acyltransferase activity", "acyl-CoA:isopenicillin N N-acyltransferase activity", "isopenicillin-N N-acyltransferase activity", "acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity", "acyl-coenzyme A:isopenicillin N acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate. [EC:2.3.1.164, MetaCyc:2.3.1.164-RXN]", "canonical_name": "isopenicillin-N acyltransferase activity"}
{"concept_id": "C1151974", "aliases": ["lysophosphatidic acid acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. [GOC:ab, PMID:16369050]", "canonical_name": "LPAAT activity"}
{"concept_id": "C1151975", "aliases": [], "types": ["T044"], "canonical_name": "malonyltransferase activity", "definition": "Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151976", "aliases": [], "types": ["T044"], "canonical_name": "S-malonyltransferase activity", "definition": "Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151977", "aliases": [], "types": ["T044"], "canonical_name": "myristoyltransferase activity", "definition": "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151978", "aliases": ["peptide N-myristoyltransferase activity", "myristoyl-coenzyme A:protein N-myristoyl transferase activity", "N-myristoyltransferase activity", "protein N-myristoyltransferase activity", "glycylpeptide N-tetradecanoyltransferase activity", "peptide N-tetradecanoyltransferase activity", "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. [EC:2.3.1.97]", "canonical_name": "myristoyl-CoA-protein N-myristoyltransferase activity"}
{"concept_id": "C1151979", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine N6-myristoyltransferase activity", "definition": "Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule. [GOC:mah, PMID:1402651]"}
{"concept_id": "C1151980", "aliases": [], "types": ["T044"], "canonical_name": "protein-cysteine S-myristoyltransferase activity", "definition": "Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]. [GOC:ai, PMID:22247542, RHEA:59736]"}
{"concept_id": "C1151981", "aliases": [], "types": ["T044"], "canonical_name": "N-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151982", "aliases": [], "types": ["T044"], "canonical_name": "acyl-CoA N-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule. [GOC:mah]"}
{"concept_id": "C1151985", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine N6-palmitoyltransferase activity", "definition": "Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule. [GOC:mah, PMID:29074776]"}
{"concept_id": "C1151986", "aliases": [], "types": ["T044"], "canonical_name": "O-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151987", "aliases": ["acyl-ACP-phospholipid O-acyltransferase activity", "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity", "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity", "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity"], "types": ["T044"], "canonical_name": "acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity", "definition": "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine. [EC:2.3.1.40]"}
{"concept_id": "C1151988", "aliases": ["acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase", "uridine diphosphoacetylglucosamine acyltransferase activity", "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity", "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity", "UDP-N-acetylglucosamine acyltransferase activity", "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity"], "types": ["T044"], "canonical_name": "acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity", "definition": "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. [EC:2.3.1.129]"}
{"concept_id": "C1151989", "aliases": [], "types": ["T044"], "canonical_name": "acylglycerol O-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. [GOC:ai]"}
{"concept_id": "C1151990", "aliases": ["1-acylglycerolphosphate acyltransferase activity", "1-acylglycerol-3-phosphate O-acyltransferase activity", "lysophosphatidate acyltransferase activity", "1-acyl-sn-glycerol-3-phosphate acyltransferase activity", "1-acylglycerophosphate acyltransferase activity", "1-acyl-sn-glycerol 3-phosphate acyltransferase activity", "1-acyl-sn-glycero-3-phosphate acyltransferase activity", "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity", "1-acylglycero-3-phosphate acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. [EC:2.3.1.51, GOC:ab]", "canonical_name": "lysophosphatidic acid-acyltransferase activity"}
{"concept_id": "C1151991", "aliases": ["monoacylglycerol acyltransferase activity", "acyl coenzyme A-monoglyceride acyltransferase activity", "2-acylglycerol O-acyltransferase activity", "acylglycerol palmitoyltransferase activity", "monoglyceride acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. [PMID:4016575, RHEA:16741]", "canonical_name": "acyl-CoA:2-acylglycerol O-acyltransferase activity"}
{"concept_id": "C1151992", "aliases": ["palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity", "diglyceride O-acyltransferase activity", "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity", "1,2-diacylglycerol acyltransferase activity", "diacylglycerol acyltransferase activity", "diacylglycerol O-acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. [EC:2.3.1.20]", "canonical_name": "diglyceride acyltransferase activity"}
{"concept_id": "C1151993", "aliases": [], "types": ["T044"], "canonical_name": "carnitine O-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule. [GOC:ai]"}
{"concept_id": "C1151994", "aliases": ["carnitine O-octanoyltransferase activity", "carnitine medium-chain acyltransferase activity", "medium-chain/long-chain carnitine acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA. [EC:2.3.1.137, RHEA:17177]", "canonical_name": "octanoyl-CoA:L-carnitine O-octanoyltransferase activity"}
{"concept_id": "C1151995", "aliases": ["outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity", "palmitoylcarnitine transferase activity", "L-carnitine palmitoyltransferase activity", "acylcarnitine transferase activity", "CPTo", "carnitine palmitoyltransferase activity", "CPTi", "CPT-B", "carnitine O-palmitoyltransferase activity", "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity", "CPT-A"], "types": ["T044"], "definition": "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. [EC:2.3.1.21]", "canonical_name": "CPT"}
{"concept_id": "C1151996", "aliases": ["fatty acyl-CoA:ecdysone acyltransferase activity", "palmitoyl-CoA:ecdysone palmitoyltransferase activity", "acyl-CoA:ecdysone acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate. [EC:2.3.1.139, RHEA:15217]", "canonical_name": "ecdysone O-acyltransferase activity"}
{"concept_id": "C1151997", "aliases": [], "types": ["T044"], "canonical_name": "O-octanoyltransferase activity", "definition": "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151998", "aliases": [], "types": ["T044"], "canonical_name": "O-palmitoyltransferase activity", "definition": "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1151999", "aliases": [], "types": ["T044"], "canonical_name": "O-sinapoyltransferase activity", "definition": "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152000", "aliases": ["sinapoylglucose:malate sinapoyltransferase activity", "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity", "1-sinapoylglucose-L-malate sinapoyltransferase activity"], "types": ["T044"], "canonical_name": "sinapoylglucose-malate O-sinapoyltransferase activity", "definition": "Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate. [EC:2.3.1.92, RHEA:12625]"}
{"concept_id": "C1152001", "aliases": ["phosphatidylcholine:sterol O-acyltransferase activity", "phosphatidylcholine-sterol O-acyltransferase activity", "LCAT (lecithin-cholesterol acyltransferase)", "lecithin--cholesterol acyltransferase activity", "LCAT activity", "lecithin:cholesterol acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. [EC:2.3.1.43]", "canonical_name": "phospholipid--cholesterol acyltransferase activity"}
{"concept_id": "C1152002", "aliases": [], "types": ["T044"], "canonical_name": "protein-cysteine S-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule. [GOC:ai, RHEA:63372]"}
{"concept_id": "C1152003", "aliases": ["protein-cysteine S-palmitoleyltransferase activity"], "types": ["T044"], "canonical_name": "protein-cysteine S-palmitoyltransferase activity", "definition": "Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]. [GOC:ai, GOC:pr, RHEA:36683]"}
{"concept_id": "C1152004", "aliases": [], "types": ["T044"], "canonical_name": "serine O-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule. [GOC:ai]"}
{"concept_id": "C1152005", "aliases": ["sterol-ester synthase activity", "ACAT activity", "sterol O-acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester. [EC:2.3.1.26, GOC:mah]", "canonical_name": "sterol-ester synthetase activity"}
{"concept_id": "C1152006", "aliases": [], "types": ["T044"], "canonical_name": "octanoyltransferase activity", "definition": "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152007", "aliases": ["palmitoleoyl ACP-dependent acyltransferase activity"], "types": ["T044"], "canonical_name": "palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity", "definition": "Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]. [MetaCyc:PALMITOTRANS-RXN]"}
{"concept_id": "C1152008", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. [GOC:ai]", "canonical_name": "palmitoyltransferase activity"}
{"concept_id": "C1152009", "aliases": [], "types": ["T044"], "canonical_name": "S-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152010", "aliases": [], "types": ["T044"], "canonical_name": "dihydrolipoamide S-acyltransferase activity", "definition": "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide. [EC:2.3.1.12, GOC:mah]"}
{"concept_id": "C1152011", "aliases": ["dihydrolipoamide branched chain transacylase activity"], "types": ["T044"], "canonical_name": "dihydrolipoamide branched chain acyltransferase activity", "definition": "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain. [GOC:mah]"}
{"concept_id": "C1152012", "aliases": [], "types": ["T044"], "canonical_name": "sinapoyltransferase activity", "definition": "Catalysis of the transfer of a sinapoyl group to an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152013", "aliases": [], "types": ["T044"], "canonical_name": "succinyltransferase activity", "definition": "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152014", "aliases": [], "types": ["T044"], "canonical_name": "N-succinyltransferase activity", "definition": "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152016", "aliases": ["AST activity", "succinyl-CoA:L-arginine N2-succinyltransferase activity", "arginine N-succinyltransferase activity", "arginine succinyltransferase activity", "AstA", "arginine and ornithine N2-succinyltransferase activity", "succinyl-CoA:L-arginine 2-N-succinyltransferase activity", "AOST activity"], "types": ["T044"], "definition": "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine. [EC:2.3.1.109]", "canonical_name": "arginine and ornithine N(2)-succinyltransferase activity"}
{"concept_id": "C1152017", "aliases": [], "types": ["T044"], "canonical_name": "O-succinyltransferase activity", "definition": "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152018", "aliases": ["succinyl-CoA:L-homoserine O-succinyltransferase activity", "homoserine succinyltransferase activity"], "types": ["T044"], "canonical_name": "homoserine O-succinyltransferase activity", "definition": "Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA. [EC:2.3.1.46, RHEA:22008]"}
{"concept_id": "C1152019", "aliases": [], "types": ["T044"], "canonical_name": "S-succinyltransferase activity", "definition": "Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152020", "aliases": ["lipoate succinyltransferase (Escherichia coli) activity", "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity", "lipoic transsuccinylase activity", "dihydrolipoic transsuccinylase activity", "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity", "dihydrolipoyl transsuccinylase activity", "dihydrolipolyl transsuccinylase activity", "lipoyl transsuccinylase activity", "lipoate succinyltransferase activity", "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity", "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity", "dihydrolipoamide succinyltransferase activity", "succinyl-CoA:dihydrolipoate S-succinyltransferase activity", "dihydrolipoamide S-succinyltransferase activity"], "types": ["T044"], "canonical_name": "dihydrolipoyllysine-residue succinyltransferase activity", "definition": "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. [EC:2.3.1.61]"}
{"concept_id": "C1152022", "aliases": [], "types": ["T044"], "canonical_name": "benzoyl acetate-CoA thiolase activity", "definition": "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA. [UM-BBD_reactionID:r0243]"}
{"concept_id": "C1152023", "aliases": ["fatty acyl CoA synthase activity", "fatty-acyl-CoA synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. [EC:2.3.1.86]", "canonical_name": "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)"}
{"concept_id": "C1152024", "aliases": ["N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity", "formylmethanofuran-tetrahydromethanopterin formyltransferase activity", "FTR", "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity", "formylmethanofuran:tetrahydromethanopterin formyltransferase activity", "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity"], "types": ["T044"], "canonical_name": "formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity", "definition": "Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran. [EC:2.3.1.101, RHEA:18061]"}
{"concept_id": "C1152025", "aliases": ["DOCS"], "types": ["T044"], "definition": "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2. [EC:2.3.1.74]", "canonical_name": "naringenin-chalcone synthase activity"}
{"concept_id": "C1152026", "aliases": ["transferase activity, transferring aldehyde or ketonic groups"], "types": ["T044"], "canonical_name": "transketolase or transaldolase activity", "definition": "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1152029", "aliases": ["glycolaldehydetransferase activity", "transketolase activity"], "types": ["T044"], "definition": "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. [GOC:fmc, RHEA:10508]", "canonical_name": "glycoaldehyde transferase activity"}
{"concept_id": "C1152030", "aliases": ["transferase activity, transferring alkyl or aryl groups, other than methyl groups"], "types": ["T044"], "canonical_name": "transferase activity, transferring alkyl or aryl (other than methyl) groups", "definition": "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1152032", "aliases": ["5-enolpyruvylshikimate-3-phosphate synthase activity", "3-enol-pyruvoylshikimate-5-phosphate synthase activity", "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity", "EPSP synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate. [EC:2.5.1.19, RHEA:21256]", "canonical_name": "3-phosphoshikimate 1-carboxyvinyltransferase activity"}
{"concept_id": "C1152033", "aliases": ["adenylate isopentenyltransferase activity", "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity", "adenylate dimethylallyltransferase activity", "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity", "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity"], "types": ["T044"], "canonical_name": "AMP dimethylallyltransferase activity", "definition": "Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate. [EC:2.5.1.27, RHEA:15285]"}
{"concept_id": "C1152034", "aliases": ["dihydroxyacetone-phosphate acyltransferase activity", "alkyldihydroxyacetone phosphate synthetase activity", "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity", "alkylglycerone-phosphate synthase activity", "alkyl-DHAP", "alkyldihydroxyacetonephosphate synthase activity", "alkyl-DHAP synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion. [EC:2.5.1.26]", "canonical_name": "alkyl DHAP synthetase activity"}
{"concept_id": "C1152035", "aliases": ["cob(I)yrinic acid a,c-diamide adenosyltransferase activity", "CobA", "ATP:cob(I)alamin cobeta-adenosyltransferase activity", "ATP:corrinoid adenosyltransferase activity", "cob(I)alamin adenosyltransferase activity", "ATP:cob(I)alamin Co-beta-adenosyltransferase activity", "aquacob(I)alamin adenosyltransferase activity", "vitamin B12s adenosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin. [EC:2.5.1.17]", "canonical_name": "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity"}
{"concept_id": "C1152037", "aliases": ["dihydropteroate synthase activity", "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity", "dihydropteroate pyrophosphorylase activity", "DHPS activity", "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity", "7,8-dihydropteroate synthetase activity", "7,8-dihydropteroate synthase activity", "dihydropteroate synthetase activity", "dihydropteroic synthetase activity", "dihydropteroate diphosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. [EC:2.5.1.15]", "canonical_name": "7,8-dihydropteroic acid synthetase activity"}
{"concept_id": "C1152038", "aliases": ["diprenyltransferase activity", "dimethylallyltransferase activity", "(2E,6E)-farnesyl diphosphate synthetase activity", "geranyl diphosphate synthase", "geranyl pyrophosphate synthase activity", "trans-farnesyl pyrophosphate synthetase activity", "DMAPP:IPP-dimethylallyltransferase activity", "dimethylallyltranstransferase activity", "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. [EC:2.5.1.1]", "canonical_name": "geranyl pyrophosphate synthetase activity"}
{"concept_id": "C1152039", "aliases": ["glutathione S-alkyltransferase activity", "glutathione conjugation reaction", "glutathione transferase activity", "glutathione S-transferase activity", "S-(hydroxyalkyl)glutathione lyase activity", "glutathione S-alkyl transferase activity", "glutathione S-aryltransferase activity", "RX:glutathione R-transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. [EC:2.5.1.18]", "canonical_name": "glutathione S-aralkyltransferase activity"}
{"concept_id": "C1152040", "aliases": ["leukotriene C4 synthetase activity", "LTC(4) synthetase activity", "leukotriene A4:glutathione S-leukotrienyltransferase activity", "LTC4 synthetase activity", "leukotriene A(4):glutathione S-leukotrienyltransferase activity", "leukotriene-C4 synthase activity", "LTC4 synthase activity", "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)", "LTC(4) synthase activity", "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)", "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)"], "types": ["T044"], "definition": "Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). [EC:4.4.1.20, RHEA:17617]", "canonical_name": "leukotriene C(4) synthetase activity"}
{"concept_id": "C1152041", "aliases": ["ATP-methionine adenosyltransferase activity", "S-adenosylmethionine synthase activity", "methionine S-adenosyltransferase activity", "methionine adenosyltransferase activity", "S-adenosylmethionine synthetase activity", "S-adenosyl-L-methionine synthetase activity", "AdoMet synthetase activity", "adenosylmethionine synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. [EC:2.5.1.6]", "canonical_name": "ATP:L-methionine S-adenosyltransferase activity"}
{"concept_id": "C1152042", "aliases": ["nicotianamine synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine. [EC:2.5.1.43, RHEA:16481]", "canonical_name": "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity"}
{"concept_id": "C1152043", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). [GOC:mah]", "canonical_name": "prenyltransferase activity"}
{"concept_id": "C1152044", "aliases": ["1,4-Dihydroxy-2-naphtoate prenyltransferase activity"], "types": ["T044"], "canonical_name": "1,4-dihydroxy-2-naphthoate octaprenyltransferase activity", "definition": "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2. [RHEA:30099]"}
{"concept_id": "C1152045", "aliases": ["para-hydroxybenzoate-polyprenyl diphosphate transferase activity", "para-hydroxybenzoate:polyprenyltransferase activity", "4-HB polyprenyltransferase activity", "para-hydroxybenzoate transferase activity", "4-hydroxybenzoate octaprenyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate. [RHEA:27782]", "canonical_name": "PHB polyprenyl diphosphate transferase activity"}
{"concept_id": "C1152046", "aliases": ["chlorophyll synthetase activity", "chlorophyll synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: chlorophyllide a + 2 H(+) + phytyl diphosphate = chlorophyll a + diphosphate. [EC:2.5.1.62, RHEA:17317]", "canonical_name": "chlorophyllide-a:phytyl-diphosphate phytyltransferase activity"}
{"concept_id": "C1152047", "aliases": [], "types": ["T044"], "definition": "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate. [PMID:9858571]", "canonical_name": "dehydrodolichyl diphosphate synthase activity"}
{"concept_id": "C1152048", "aliases": ["undecaprenyl diphosphate synthase activity", "undecaprenyl pyrophosphate synthetase activity", "undecaprenyl-diphosphate synthase activity", "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity", "UPP synthetase activity", "undecaprenyl diphosphate synthetase activity", "undecaprenyl pyrophosphate synthase activity", "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity"], "types": ["T044"], "canonical_name": "di-trans,poly-cis-decaprenylcistransferase activity", "definition": "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate. [EC:2.5.1.31]"}
{"concept_id": "C1152049", "aliases": ["geranylgeranyl pyrophosphate synthase activity", "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity", "geranylgeranyl pyrophosphate synthetase activity", "farnesyltranstransferase activity", "geranylgeranyl-diphosphate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. [EC:2.5.1.29, RHEA:17653]", "canonical_name": "geranylgeranyl-PP synthetase activity"}
{"concept_id": "C1152050", "aliases": ["farnesyl-diphosphate farnesyltransferase activity", "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity", "presqualene synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. [EC:2.5.1.21]", "canonical_name": "presqualene-diphosphate synthase activity"}
{"concept_id": "C1152051", "aliases": ["protoheme IX farnesyltransferase activity", "protohaem IX farnesyltransferase activity", "heme A:farnesyltransferase activity", "heme O synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. [RHEA:28070]", "canonical_name": "haem O synthase activity"}
{"concept_id": "C1152052", "aliases": ["geranyltransferase activity", "farnesylpyrophosphate synthetase activity", "farnesyl diphosphate synthetase activity", "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity", "farnesyl-diphosphate synthase activity", "farnesyl pyrophosphate synthetase activity", "FPP synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate. [EC:2.5.1.10, RHEA:19361]", "canonical_name": "geranyltranstransferase activity"}
{"concept_id": "C1152053", "aliases": ["geranylgeranyl-diphosphate geranylgeranyltransferase activity", "phytoene synthetase activity", "prephytoene-diphosphate synthase activity", "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate. [EC:2.5.1.32]", "canonical_name": "PSase activity"}
{"concept_id": "C1152054", "aliases": [], "types": ["T044"], "canonical_name": "protein prenyltransferase activity", "definition": "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. [GOC:mah]"}
{"concept_id": "C1152056", "aliases": ["protein farnesyltransferase activity", "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity", "FTase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. [EC:2.5.1.58, PMID:8621375]", "canonical_name": "protein-cysteine farnesyltransferase activity"}
{"concept_id": "C1152057", "aliases": ["protein-cysteine geranylgeranyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. [PMID:8621375]", "canonical_name": "protein geranylgeranyltransferase activity"}
{"concept_id": "C1152059", "aliases": ["type I protein geranyl-geranyltransferase activity", "GGTaseI activity", "GGTase-I activity", "geranylgeranyltransferase type I activity", "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity"], "types": ["T044"], "canonical_name": "CAAX-protein geranylgeranyltransferase activity", "definition": "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. [EC:2.5.1.59, PMID:8621375]"}
{"concept_id": "C1152060", "aliases": ["geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity", "GGTaseII activity", "type II protein geranyl-geranyltransferase activity", "protein geranylgeranyltransferase type II activity", "RabGGTase activity", "Rab-protein geranylgeranyltransferase activity", "GGTase-II activity"], "types": ["T044"], "canonical_name": "Rab geranylgeranyltransferase activity", "definition": "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. [EC:2.5.1.60, GOC:mah, PMID:8621375]"}
{"concept_id": "C1152061", "aliases": ["vitamin B2 synthase activity", "riboflavine synthase activity", "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity", "riboflavine synthetase activity", "riboflavin synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin. [EC:2.5.1.9, RHEA:20772]", "canonical_name": "riboflavin synthase activity"}
{"concept_id": "C1152062", "aliases": ["S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity", "spermidine synthetase activity", "aminopropyltransferase activity", "putrescine aminopropyltransferase activity", "spermidine synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. [EC:2.5.1.16]", "canonical_name": "SpeE"}
{"concept_id": "C1152063", "aliases": ["S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity", "spermine synthase activity", "spermine synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. [EC:2.5.1.22]", "canonical_name": "spermidine aminopropyltransferase activity"}
{"concept_id": "C1152064", "aliases": ["thiamine-phosphate synthase activity", "TMP-PPase activity", "thiamin-phosphate pyrophosphorylase activity", "thiamine monophosphate pyrophosphorylase activity", "thiamin-phosphate diphosphorylase activity", "TMP diphosphorylase activity", "TMP pyrophosphorylase activity", "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity", "thiamine phosphate pyrophosphorylase activity", "thiamine-phosphate pyrophosphorylase activity"], "types": ["T044"], "canonical_name": "thiamine-phosphate diphosphorylase activity", "definition": "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate. [EC:2.5.1.3, RHEA:22328]"}
{"concept_id": "C1152065", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate. [PMID:9708911, RHEA:20836]", "canonical_name": "trans-hexaprenyltranstransferase activity"}
{"concept_id": "C1152066", "aliases": [], "types": ["T044"], "canonical_name": "tRNA isopentenyltransferase activity"}
{"concept_id": "C1152067", "aliases": ["S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine. [EC:2.5.1.25]", "canonical_name": "tRNA-uridine aminocarboxypropyltransferase activity"}
{"concept_id": "C1152068", "aliases": ["phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity", "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity", "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity", "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity", "UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity", "pyruvate-UDP-acetylglucosamine transferase activity", "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity", "enoylpyruvate transferase activity", "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity", "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity", "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity", "UDP-N-acetylglucosamine enoylpyruvyltransferase activity", "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. [EC:2.5.1.7, RHEA:18681]", "canonical_name": "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity"}
{"concept_id": "C1152069", "aliases": ["glycosyltransferase activity", "transglycosidase activity", "transferase activity, transferring glycosyl groups"], "types": ["T044"], "definition": "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]", "canonical_name": "transglycosylase activity"}
{"concept_id": "C1152070", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity", "definition": "Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein. [PMID:8051048, RHEA:56712]"}
{"concept_id": "C1152071", "aliases": ["transferase activity, transferring hexosyl groups"], "types": ["T044"], "definition": "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). [GOC:jl]", "canonical_name": "hexosyltransferase activity"}
{"concept_id": "C1152073", "aliases": ["GalNAc transferase activity"], "types": ["T044"], "canonical_name": "acetylgalactosaminyltransferase activity", "definition": "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. [ISBN:0198506732]"}
{"concept_id": "C1152074", "aliases": ["asialo-GM2 synthase activity", "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity", "ganglioside GM3 acetylgalactosaminyltransferase activity", "GM2/GD2-synthase activity", "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity", "beta-1,4N-aetylgalactosaminyltransferase activity", "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity", "GalNAc-T activity", "(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity", "GM2 synthase activity", "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity", "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity", "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity", "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide. [EC:2.4.1.92]", "canonical_name": "ganglioside GM2 synthase activity"}
{"concept_id": "C1152075", "aliases": ["UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity", "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity", "A-transferase activity", "fucosylgalactose acetylgalactosaminyltransferase activity", "alpha-3-N-acetylgalactosaminyltransferase activity", "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity", "A transferase activity", "blood-group substance A-dependent acetylgalactosaminyltransferase activity", "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity", "blood-group substance alpha-acetyltransferase activity", "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity", "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)"], "types": ["T044"], "canonical_name": "glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. [EC:2.4.1.40]"}
{"concept_id": "C1152076", "aliases": ["UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity", "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity", "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity", "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity", "protein-UDP acetylgalactosaminyltransferase activity", "polypeptide N-acetylgalactosaminyltransferase activity", "glycoprotein acetylgalactosaminyltransferase activity", "polypeptide-N-acetylgalactosamine transferase activity", "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity", "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity", "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity", "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity", "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity", "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity", "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. [EC:2.4.1.41, ISBN:0879695595]", "canonical_name": "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity"}
{"concept_id": "C1152077", "aliases": ["GlcNAc transferase activity"], "types": ["T044"], "canonical_name": "acetylglucosaminyltransferase activity", "definition": "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. [ISBN:0198506732]"}
{"concept_id": "C1152078", "aliases": ["GnTV activity", "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity", "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity", "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity", "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity", "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors. [EC:2.4.1.155]", "canonical_name": "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity"}
{"concept_id": "C1152079", "aliases": ["UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity", "GnTI", "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity", "GNTI activity", "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity", "alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity", "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity", "N-acetylglucosaminyltransferase I activity", "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP. [EC:2.4.1.101, RHEA:11456]", "canonical_name": "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity"}
{"concept_id": "C1152080", "aliases": ["beta-acetylglucosaminyltransferase IV activity", "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity", "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity", "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity", "GnTIV activity", "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity", "N-acetylglucosaminyltransferase IV activity", "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R. [EC:2.4.1.145]", "canonical_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity"}
{"concept_id": "C1152081", "aliases": ["uridine diphosphoacetylglucosamine-alpha-D-mannoside beta(1,2)-acetylglucosaminyltransferase activity", "N-acetylglucosaminyltransferase II activity", "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity", "UDP-GlcNAc:mannoside alpha-(1,6) acetylglucosaminyltransferase activity", "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-mannoside alpha(1,6)-acetylglucosaminyltransferase activity", "GnTII activity", "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity", "UDP-GlcNAc:mannoside alpha-1,6 acetylglucosaminyltransferase activity", "acetylglucosaminyltransferase II activity", "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity", "uridine diphosphoacetylglucosamine-mannoside alpha-1,6-acetylglucosaminyltransferase activity", "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1,2-acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R. [EC:2.4.1.143]"}
{"concept_id": "C1152082", "aliases": ["uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity", "core 2 acetylglucosaminyltransferase activity", "beta(6)-N-acetylglucosaminyltransferase activity", "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity", "beta6-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R. [EC:2.4.1.102]", "canonical_name": "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity"}
{"concept_id": "C1152085", "aliases": ["chitin synthetase activity", "chitin-UDP N-acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity", "chitin synthase activity", "trans-N-acetylglucosaminosylase activity", "chitin-UDP acetyl-glucosaminyl transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1). [EC:2.4.1.16]", "canonical_name": "chitin-uridine diphosphate acetylglucosaminyltransferase activity"}
{"concept_id": "C1152086", "aliases": ["uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity", "dolichyl phosphate acetylglucosaminyltransferase activity", "dolichyl-phosphate acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity", "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity", "dolichyl-phosphate N-acetylglucosaminyltransferase activity", "dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate. [EC:2.4.1.153]", "canonical_name": "dolichyl phosphate N-acetylglucosaminyltransferase activity"}
{"concept_id": "C1152087", "aliases": ["heparan sulphate N-acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "heparan sulfate N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate. [GOC:ma]"}
{"concept_id": "C1152088", "aliases": ["uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity", "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity", "LPS N-acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide. [EC:2.4.1.56, GOC:mr]", "canonical_name": "lipopolysaccharide N-acetylglucosaminyltransferase activity"}
{"concept_id": "C1152089", "aliases": ["N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity", "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity", "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol. [EC:2.4.1.141]", "canonical_name": "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity"}
{"concept_id": "C1152090", "aliases": ["UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity", "GnTE activity", "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity", "UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity", "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity", "UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity", "N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.149]", "canonical_name": "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity"}
{"concept_id": "C1152091", "aliases": ["UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity", "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity", "N-acetylglucosaminyltransferase activity", "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity", "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.150]", "canonical_name": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity"}
{"concept_id": "C1152092", "aliases": ["phosphatidylinositol N-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity", "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. [EC:2.4.1.198]", "canonical_name": "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity"}
{"concept_id": "C1152093", "aliases": ["N-GlcNAc transferase activity", "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity", "protein N-acetylglucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. [EC:2.4.1.94]", "canonical_name": "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity"}
{"concept_id": "C1152095", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]", "canonical_name": "fucosyltransferase activity"}
{"concept_id": "C1152096", "aliases": ["guanosine diphosphofucose-lactose fucosyltransferase activity", "galactoside 2-alpha-L-fucosyltransferase activity", "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity", "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity", "alpha-(1->2)-L-fucosyltransferase activity", "alpha-2-L-fucosyltransferase activity", "beta-galactoside alpha1->2 fucosyltransferase activity", "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity", "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity", "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity", "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity", "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity", "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity", "alpha-2-fucosyltransferase activity", "guanosine diphospho-L-fucose-lactose fucosyltransferase activity", "GDP-L-fucose:lactose fucosyltransferase activity", "alpha(1,2)-L-fucosyltransferase activity", "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity", "galactoside 2-L-fucosyltransferase activity", "beta-galactoside alpha-1->2 fucosyltransferase activity", "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity", "GDP fucose-lactose fucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. [EC:2.4.1.69, RHEA:50664]", "canonical_name": "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity"}
{"concept_id": "C1152097", "aliases": ["GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity", "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity", "alpha-(1->4)-L-fucosyltransferase activity", "alpha(1,4)-L-fucosyltransferase activity", "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity", "alpha-(1,4)-L-fucosyltransferase activity", "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity", "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity", "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.65]", "canonical_name": "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity"}
{"concept_id": "C1152098", "aliases": ["galactoside 3-L-fucosyltransferase activity", "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity", "Lewis-negative alpha-3-fucosyltransferase activity", "galactoside 3-fucosyltransferase activity", "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity", "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity", "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity", "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "definition": "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.152, RHEA:14257]"}
{"concept_id": "C1152099", "aliases": [], "types": ["T044"], "canonical_name": "galactoside 6-L-fucosyltransferase activity", "definition": "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside. [PMID:12413479]"}
{"concept_id": "C1152100", "aliases": ["GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity", "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity", "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity", "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity", "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity", "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity", "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity", "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity", "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity", "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity"], "types": ["T044"], "canonical_name": "glycoprotein 3-alpha-L-fucosyltransferase activity", "definition": "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+). [EC:2.4.1.214, RHEA:24444]"}
{"concept_id": "C1152101", "aliases": ["GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1,6)fucosyltransferase activity", "GDP-fucose--glycoprotein fucosyltransferase activity", "glycoprotein 6-alpha-L-fucosyltransferase activity", "FucT", "GDP-L-fucose--glycoprotein fucosyltransferase activity", "guanosine diphosphofucose--glycoprotein fucosyltransferase activity", "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity", "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity", "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1,6)fucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+). [EC:2.4.1.68, RHEA:12985]", "canonical_name": "GDPfucose-glycoprotein fucosyltransferase activity"}
{"concept_id": "C1152102", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [ISBN:0198506732]", "canonical_name": "galactosyltransferase activity"}
{"concept_id": "C1152103", "aliases": ["uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity", "MGDG synthase activity", "UDP-galactose-diacylglyceride galactosyltransferase activity", "monogalactosyldiacylglycerol synthase activity", "UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity", "UDP-galactose:diacylglycerol galactosyltransferase activity", "UDP galactose-1,2-diacylglycerol galactosyltransferase activity", "1,2-diacylglycerol 3-beta-galactosyltransferase activity", "1-beta-MGDG activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP. [EC:2.4.1.46, RHEA:14945]", "canonical_name": "UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity"}
{"concept_id": "C1152104", "aliases": ["UDPgalactose:ceramide galactosyltransferase activity", "UDP-galactose-GM2 ganglioside galactosyltransferase activity", "uridine diphosphate D-galactose:glycolipid galactosyltransferase activity", "UDPgalactose-ceramide galactosyltransferase activity", "UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity", "UDP-galactose-ceramide galactosyltransferase activity", "GM1-synthase activity", "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity", "cerebroside synthase activity", "2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity", "ganglioside galactosyltransferase activity", "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity", "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity", "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity", "UDP-galactose-GM2 galactosyltransferase activity", "uridine diphosphogalactose-GM2 galactosyltransferase activity", "uridine diphosphogalactose-ceramide galactosyltransferase activity", "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity", "UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity", "UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine. [EC:2.4.1.45]", "canonical_name": "UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity"}
{"concept_id": "C1152105", "aliases": ["glycoprotein 4-beta-galactosyl-transferase activity", "uridine diphosphogalactose-glycoprotein galactosyltransferase activity", "beta-N-acetyl-beta-(1,4)-galactosyltransferase activity", "beta-N-acetyl-beta-1,4-galactosyltransferase activity", "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity", "glycoprotein 4-beta-galactosyltransferase activity", "UDP-galactose--glycoprotein galactosyltransferase activity", "UDPgalactose-glycoprotein galactosyltransferase activity", "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity", "glycoprotein beta-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. [EC:2.4.1.38]"}
{"concept_id": "C1152106", "aliases": ["3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity", "galactolipid-galactolipid galactosyltransferase activity", "GGGT activity", "galactolipid galactosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol. [EC:2.4.1.184]", "canonical_name": "galactolipid:galactolipid galactosyltransferase activity"}
{"concept_id": "C1152107", "aliases": ["glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity", "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity", "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity", "UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity", "fucosylglycoprotein 3-alpha-galactosyltransferase activity", "UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity", "UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity", "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity", "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity", "histo-blood substance B-dependent galactosyltransferase activity"], "types": ["T044"], "canonical_name": "fucosylgalactoside 3-alpha-galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. [EC:2.4.1.37]"}
{"concept_id": "C1152108", "aliases": ["UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity", "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity", "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan. [EC:2.4.1.122, GOC:ma]", "canonical_name": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"}
{"concept_id": "C1152109", "aliases": ["uridine diphosphogalactose-glucose galactosyltransferase activity", "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity", "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity", "UDPgalactose-glucose galactosyltransferase activity", "lactose synthetase activity", "lactose synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose. [EC:2.4.1.22]", "canonical_name": "UDP-galactose-glucose galactosyltransferase activity"}
{"concept_id": "C1152110", "aliases": ["lipopolysaccharide 1,3-galactosyltransferase activity", "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity", "UDP-galactose:polysaccharide galactosyltransferase activity", "LPS 3-alpha-galactosyltransferase activity", "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity", "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity", "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity", "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity", "lipopolysaccharide 3-alpha-galactosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide. [EC:2.4.1.44, GOC:mr]", "canonical_name": "lipopolysaccharide galactosyltransferase activity"}
{"concept_id": "C1152111", "aliases": ["LPS-1,6-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "lipopolysaccharide-1,6-galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide. [GOC:ai]"}
{"concept_id": "C1152112", "aliases": ["beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity", "lactosamine synthetase activity", "beta-1,4-galactosyltransferase activity", "N-acetylglucosamine (beta-1,4)galactosyltransferase activity", "NAL synthetase activity", "UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity", "beta-(1,4)-galactosyltransferase activity", "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity", "UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity", "lactosamine synthase activity", "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity", "acetyllactosamine synthetase activity", "N-acetyllactosamine synthase activity", "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity", "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity", "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity", "Gal-T", "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity", "N-acetyllactosamine synthetase activity", "UDP-galactose-acetylglucosamine galactosyltransferase activity", "UDP-beta-1,4-galactosyltransferase activity", "N-acetylglucosamine beta-(1,4)-galactosyltransferase activity", "UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity", "UDP-galactose-N-acetylglucosamine galactosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. [EC:2.4.1.90]", "canonical_name": "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity"}
{"concept_id": "C1152114", "aliases": ["UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity", "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. [PMID:10212226]"}
{"concept_id": "C1152115", "aliases": ["lactosylceramide synthase activity", "LacCer synthase activity", "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base. [MetaCyc:RXN-10764, PMID:9593693]"}
{"concept_id": "C1152116", "aliases": ["UDP-galactose-dependent DGDG synthase activity", "DGD1", "UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity", "digalactosyldiacylglycerol synthase activity", "UDP-galactose-dependent digalactosyldiacylglycerol synthase activity", "DGD2", "DGDG synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H(+) + UDP. [EC:2.4.1.241, RHEA:10520]", "canonical_name": "UDP-galactose:MGDG galactosyltransferase activity"}
{"concept_id": "C1152117", "aliases": ["UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity", "uridine diphosphogalactose-xylose galactosyltransferase activity", "UDP-D-galactose:D-xylose galactosyltransferase activity", "UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity", "xylosylprotein 4-beta-galactosyltransferase activity", "UDP-D-galactose:xylose galactosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein. [EC:2.4.1.133]", "canonical_name": "UDP-galactose:xylose galactosyltransferase activity"}
{"concept_id": "C1152118", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [ISBN:0198506732]", "canonical_name": "glucosyltransferase activity"}
{"concept_id": "C1152119", "aliases": [], "types": ["T044"], "canonical_name": "1,2-dihydroxy-phenanthrene glycosyltransferase activity", "definition": "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP. [UM-BBD_reactionID:r0569]"}
{"concept_id": "C1152120", "aliases": ["GS-II", "(1,3)-beta-glucan (callose) synthase activity", "beta-1,3-glucan synthetase activity", "UDP-glucose:(1,3)beta-glucan synthase activity", "UDP-glucose-1,3-beta-glucan glucosyltransferase activity", "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity", "callose synthetase activity", "1,3-beta-glucan synthase activity", "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity", "callose synthase activity", "UDP-glucose-beta-glucan glucosyltransferase activity", "1,3-beta-D-glucan synthetase activity", "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity", "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity", "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity", "beta-1,3-glucan synthase activity", "1,3-beta-D-glucan-UDP glucosyltransferase activity"], "types": ["T044"], "canonical_name": "1,3-beta-D-glucan synthase activity", "definition": "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1). [EC:2.4.1.34]"}
{"concept_id": "C1152121", "aliases": ["trehalosephosphate-UDP glucosyl transferase activity", "alpha,alpha-trehalose phosphate synthase (UDP-forming)", "trehalose phosphate synthase activity", "transglucosylase activity", "trehalosephosphate-UDP glucosyltransferase activity", "UDPglucose-glucose-phosphate glucosyltransferase activity", "trehalose phosphate-uridine diphosphate glucosyltransferase activity", "trehalose-P synthetase activity", "trehalose-phosphate synthetase activity", "uridine diphosphoglucose phosphate glucosyltransferase activity", "trehalose phosphate synthetase activity", "trehalose 6-phosphate synthase activity", "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity", "phosphotrehalose-uridine diphosphate transglucosylase activity", "trehalose-phosphate synthase activity", "UDP-glucose-glucosephosphate glucosyltransferase activity", "UDP-glucose-glucose-phosphate glucosyltransferase activity", "trehalose 6-phosphate synthetase activity", "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity", "definition": "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate. [EC:2.4.1.15]"}
{"concept_id": "C1152122", "aliases": ["cellulose synthetase activity"], "types": ["T044"], "canonical_name": "cellulose synthase activity", "definition": "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1). [EC:2.4.1.12, EC:2.4.1.29]"}
{"concept_id": "C1152123", "aliases": ["GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity", "cellulose synthase (GDP-forming) activity", "guanosine diphosphoglucose-cellulose glucosyltransferase activity", "GDP-glucose-beta-D-glucan glucosyltransferase activity", "GDP-glucose-cellulose glucosyltransferase activity", "cellulose synthase (guanosine diphosphate-forming) activity", "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1). [EC:2.4.1.29]", "canonical_name": "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity"}
{"concept_id": "C1152124", "aliases": ["UDPglucose-beta-glucan glucosyltransferase activity", "UDP-glucose-beta-D-glucan glucosyltransferase activity", "GS-I", "UDP-glucose-1,4-beta-glucan glucosyltransferase activity", "glucan synthase activity", "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity", "beta-glucan synthase activity", "beta-1,4-glucosyltransferase activity", "cellulose synthase (UDP-forming) activity", "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity", "UDPglucose-cellulose glucosyltransferase activity", "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity", "beta-1,4-glucan synthetase activity", "UDP-glucose-cellulose glucosyltransferase activity", "beta-1,4-glucan synthase activity", "1,4-beta-glucan synthase activity", "1,4-beta-D-glucan synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1). [EC:2.4.1.12]", "canonical_name": "uridine diphosphoglucose-cellulose glucosyltransferase activity"}
{"concept_id": "C1152125", "aliases": ["UDP-glucose:N-acylsphingosine D-glucosyltransferase activity", "UDP-glucose-ceramide glucosyltransferase activity", "UDPglucose:N-acylsphingosine D-glucosyltransferase activity", "ceramide:UDPGlc glucosyltransferase activity", "ceramide:UDP-glucose glucosyltransferase activity", "UDP-glucose:ceramide glucosyltransferase activity", "ceramide glucosyltransferase activity", "uridine diphosphoglucose-ceramide glucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. [EC:2.4.1.80]", "canonical_name": "glucosylceramide synthase activity"}
{"concept_id": "C1152126", "aliases": ["dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity"], "types": ["T044"], "canonical_name": "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "definition": "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol. [MetaCyc:RXN-5471, PMID:12480927]"}
{"concept_id": "C1152127", "aliases": ["dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity"], "types": ["T044"], "canonical_name": "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "definition": "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. [GOC:al, MetaCyc:RXN-5470]"}
{"concept_id": "C1152128", "aliases": ["UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity", "UDP-glucose:dolichyl phosphate glucosyltransferase activity", "UDP-glucose:dolichyl monophosphate glucosyltransferase activity", "UDP-glucose:dolichol phosphate glucosyltransferase activity", "dolichyl-phosphate beta-glucosyltransferase activity", "UDP-glucose dolichyl-phosphate glucosyltransferase activity", "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity", "uridine diphosphoglucose-dolichol glucosyltransferase activity", "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate. [EC:2.4.1.117]", "canonical_name": "UDP-glucose:dolicholphosphoryl glucosyltransferase activity"}
{"concept_id": "C1152129", "aliases": [], "types": ["T044"], "canonical_name": "dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity", "definition": "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide. [GOC:mah]"}
{"concept_id": "C1152130", "aliases": ["glycogen (starch) synthase activity", "uridine diphosphoglucose-glycogen glucosyltransferase activity", "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity", "UDPG-glycogen transglucosylase activity", "UDP-glucose-glycogen glucosyltransferase activity", "UDP-glycogen synthase activity", "UDPG-glycogen synthetase activity", "glycogen (starch) synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1). [EC:2.4.1.11]", "canonical_name": "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity"}
{"concept_id": "C1152131", "aliases": ["glycogenin glucosyltransferase activity", "alpha-1,4-glucan-protein synthase (UDP-forming) activity", "1,4alpha-glucan-protein synthase (UDP-forming) activity", "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. [EC:2.4.1.186]", "canonical_name": "UDP-glucose:glycogenin glucosyltransferase activity"}
{"concept_id": "C1152132", "aliases": ["lipopolysaccharide glucosyltransferase I activity", "UDP-glucose:lipopolysaccharide glucosyltransferase activity", "lipopolysaccharide glucosyltransferase activity", "UDPglucose:lipopolysaccharide glucosyltransferase activity", "UDPglucose:lipopolysaccharide glucosyltransferase I", "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide. [EC:2.4.1.58, GOC:mr]", "canonical_name": "LPS glucosyltransferase I activity"}
{"concept_id": "C1152133", "aliases": ["starch synthase activity", "adenosine diphosphoglucose-starch glucosyltransferase activity", "glycogen synthase activity", "ADP-glucose transglucosylase activity", "ADPG-starch glucosyltransferase activity", "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity", "starch (bacterial glycogen) synthase activity", "ADP-glucose--starch glucosyltransferase activity", "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity", "ADPglucose-starch glucosyltransferase activity", "adenosine diphosphate glucose-starch glucosyltransferase activity", "starch synthetase activity", "ADP-glucose starch synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). [EC:2.4.1.21]", "canonical_name": "ADPG starch synthetase activity"}
{"concept_id": "C1152134", "aliases": ["UDP-glucose-sterol glucosyltransferase activity", "UDP-glucose:sterol glucosyltransferase activity", "uridine diphosphoglucose-sterol glucosyltransferase activity", "sterol glucosyltransferase activity", "sterol:UDPG glucosyltransferase activity", "sterol-beta-D-glucosyltransferase activity", "UDP-glucose-sterol beta-glucosyltransferase activity", "UDPG-SGTase activity", "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity", "sterol 3-beta-glucosyltransferase activity", "uridine diphosphoglucose-poriferasterol glucosyltransferase activity", "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity", "UDPG:sterol glucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol. [EC:2.4.1.173, RHEA:22724]", "canonical_name": "sterol 3beta-glucosyltransferase activity"}
{"concept_id": "C1152135", "aliases": ["UDPglucose-fructose glucosyltransferase activity", "sucrose-UDP glucosyltransferase activity", "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity", "uridine diphosphoglucose-fructose glucosyltransferase activity", "UDP-glucose-fructose glucosyltransferase activity", "sucrose-uridine diphosphate glucosyltransferase activity", "sucrose synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose. [EC:2.4.1.13]", "canonical_name": "sucrose synthetase activity"}
{"concept_id": "C1152136", "aliases": ["UDPglucose-fructose-phosphate glucosyltransferase activity", "sucrose phosphate synthetase activity", "UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity", "sucrose 6-phosphate synthase activity", "SPS", "uridine diphosphoglucose-fructose phosphate glucosyltransferase activity", "sucrose-phosphate synthase activity", "UDP-glucose-fructose-phosphate glucosyltransferase activity", "sucrosephosphate-UDP glucosyltransferase activity", "sucrose phosphate-uridine diphosphate glucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. [EC:2.4.1.14]", "canonical_name": "UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity"}
{"concept_id": "C1152137", "aliases": ["UGGT activity"], "types": ["T044"], "canonical_name": "UDP-glucose:glycoprotein glucosyltransferase activity", "definition": "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins. [GOC:al, PMID:10764828]"}
{"concept_id": "C1152138", "aliases": ["UDP glucuronosyltransferase activity", "UDPGA-glucuronyltransferase activity", "glucuronosyltransferase activity", "UDP-glucuronyltransferase activity", "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "UDP-glucuronosyltransferase activity", "UDPGA transferase activity", "uridine diphosphate glucuronyltransferase activity", "GT activity", "uridine diphosphoglucuronyltransferase activity", "uridine 5'-diphosphoglucuronyltransferase activity", "UDPGT activity", "UDP glucuronic acid transferase activity", "UDP glucuronyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [RHEA:21032]", "canonical_name": "uridine diphosphoglucuronosyltransferase activity"}
{"concept_id": "C1152139", "aliases": [], "types": ["T044"], "canonical_name": "9-phenanthrol UDP-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP. [UM-BBD_reactionID:r0567]"}
{"concept_id": "C1152140", "aliases": ["uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity", "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. [EC:2.4.1.135]", "canonical_name": "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity"}
{"concept_id": "C1152141", "aliases": ["lipid-A-disaccharide synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H(+) + UDP. [EC:2.4.1.182, RHEA:22668]", "canonical_name": "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity"}
{"concept_id": "C1152142", "aliases": [], "types": ["T044"], "canonical_name": "mannosyltransferase activity", "definition": "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai, GOC:cjm]"}
{"concept_id": "C1152143", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage. [GOC:mcc, PMID:10521541]", "canonical_name": "alpha-1,2-mannosyltransferase activity"}
{"concept_id": "C1152144", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1,3-mannosyltransferase activity", "definition": "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage. [GOC:mcc, PMID:10521541]"}
{"concept_id": "C1152145", "aliases": ["1,6-alpha-mannosyltransferase activity"], "types": ["T044"], "canonical_name": "alpha-1,6-mannosyltransferase activity", "definition": "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage. [GOC:mcc, PMID:2644248]"}
{"concept_id": "C1152146", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage. [GOC:mcc, PMID:8166646]", "canonical_name": "beta-1,4-mannosyltransferase activity"}
{"concept_id": "C1152148", "aliases": ["mannosylphosphoryldolichol synthase activity", "GDPMan:DolP mannosyltransferase activity", "dolichyl-phospho-mannose synthase activity", "dolichol-phosphate mannosyltransferase activity", "dolichol-phosphate-mannose synthase activity", "mannosylphosphodolichol synthase activity", "GDP-mannose-dolichol phosphate mannosyltransferase activity", "GDPmannose:dolichyl-phosphate mannosyltransferase activity", "dolichyl mannosyl phosphate synthase activity", "dolichol-phosphate mannose synthase activity", "DPM synthase activity", "GDPmannose-dolichylmonophosphate mannosyltransferase activity", "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity", "dolichyl-phosphate mannose synthase activity", "dolichol phosphate mannose synthase activity", "dolichyl phosphate mannosyltransferase activity", "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity"], "types": ["T044"], "canonical_name": "dolichyl-phosphate beta-D-mannosyltransferase activity", "definition": "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. [EC:2.4.1.83]"}
{"concept_id": "C1152150", "aliases": ["dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity", "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity", "dolichol phosphomannose-protein mannosyltransferase activity", "protein O-mannosyltransferase activity", "protein O-D-mannosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein. [EC:2.4.1.109, GOC:pr]", "canonical_name": "dolichyl-phosphate-mannose-protein mannosyltransferase activity"}
{"concept_id": "C1152151", "aliases": ["glycolipid mannosyl transferase activity"], "types": ["T044"], "canonical_name": "glycolipid mannosyltransferase activity", "definition": "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage. [GOC:ai]"}
{"concept_id": "C1152152", "aliases": ["oligosaccharide-lipid mannosyltransferase activity", "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity", "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity", "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity", "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity", "glycolipid 2-alpha-mannosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. [EC:2.4.1.131]", "canonical_name": "GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity"}
{"concept_id": "C1152153", "aliases": ["mannosyltransferase II activity", "GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity", "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity", "GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity", "glycolipid 3-alpha-mannosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage. [EC:2.4.1.132]", "canonical_name": "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity"}
{"concept_id": "C1152154", "aliases": ["GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine. [EC:2.4.1.110]", "canonical_name": "tRNA-queuosine beta-mannosyltransferase activity"}
{"concept_id": "C1152155", "aliases": ["oligosaccharide transferase activity"], "types": ["T044"], "canonical_name": "oligosaccharyl transferase activity", "definition": "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]"}
{"concept_id": "C1152156", "aliases": ["asparagine N-glycosyltransferase activity", "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity", "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity", "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity", "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity", "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity", "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity"], "types": ["T044"], "canonical_name": "dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "definition": "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. [RHEA:22980]"}
{"concept_id": "C1152157", "aliases": ["peptidoglycan glycosyltransferase activity", "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity", "peptidoglycan TGase activity", "PG-II activity", "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate. [EC:2.4.1.129]", "canonical_name": "peptidoglycan transglycosylase activity"}
{"concept_id": "C1152158", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrol glycosyltransferase activity", "definition": "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O. [GOC:ai]"}
{"concept_id": "C1152159", "aliases": [], "types": ["T044"], "canonical_name": "1-phenanthrol glycosyltransferase activity", "definition": "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O. [UM-BBD_reactionID:r0525]"}
{"concept_id": "C1152160", "aliases": [], "types": ["T044"], "canonical_name": "9-phenanthrol glycosyltransferase activity", "definition": "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O. [UM-BBD_reactionID:r0511]"}
{"concept_id": "C1152161", "aliases": ["polyphosphorylase activity", "1,4-alpha-glucan phosphorylase activity", "1,4-alpha-oligoglucan phosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. [EC:2.4.1.1]", "canonical_name": "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity"}
{"concept_id": "C1152162", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN]", "canonical_name": "glycogen phosphorylase activity"}
{"concept_id": "C1152163", "aliases": ["sucrose:phosphate alpha-D-glucosyltransferase activity", "sucrose phosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate. [EC:2.4.1.7]", "canonical_name": "sucrose glucosyltransferase activity"}
{"concept_id": "C1152164", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glycosyltransferase activity", "definition": "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. [InterPro:IPR004224, PMID:11846783]"}
{"concept_id": "C1152165", "aliases": ["UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP. [MetaCyc:RXN-1224]", "canonical_name": "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity"}
{"concept_id": "C1152166", "aliases": ["endo-xyloglucan transferase activity", "xyloglucan:xyloglucosyl transferase activity", "endoxyloglucan transferase activity", "xyloglucan endotransglucosylase activity"], "types": ["T044"], "definition": "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. [EC:2.4.1.207, GOC:ask, PMID:1400418, PMID:1554366]", "canonical_name": "xyloglucan:xyloglucan xyloglucanotransferase activity"}
{"concept_id": "C1152167", "aliases": [], "types": ["T044"], "canonical_name": "transferase activity, transferring other glycosyl groups", "definition": "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor). [GOC:jl]"}
{"concept_id": "C1152168", "aliases": ["ADP-heptose:LPS heptosyltransferase activity"], "types": ["T044"], "canonical_name": "ADP-heptose-lipopolysaccharide heptosyltransferase activity", "definition": "Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. [MetaCyc:RXN0-5061]"}
{"concept_id": "C1152169", "aliases": ["LPS heptosyltransferase activity"], "types": ["T044"], "canonical_name": "lipopolysaccharide heptosyltransferase activity", "definition": "Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+. [MetaCyc:RXN0-5061, MetaCyc:RXN0-5122, MetaCyc:RXN0-5127]"}
{"concept_id": "C1152170", "aliases": [], "types": ["T044"], "canonical_name": "murein lytic endotransglycosylase E activity"}
{"concept_id": "C1152171", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. [GOC:cjm, PMID:26192491, Wikipedia:Sialyltransferase]", "canonical_name": "sialyltransferase activity"}
{"concept_id": "C1152172", "aliases": ["CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity", "GalNAc alpha-2,6-sialyltransferase I activity"], "types": ["T044"], "canonical_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "definition": "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. [EC:2.4.99.3]"}
{"concept_id": "C1152173", "aliases": ["CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity", "SAT-2", "ganglioside GD3 synthase activity", "alpha-2,8-sialyltransferase activity", "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity", "GD3 synthase activity", "ganglioside GD3 synthetase sialyltransferase activity", "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity", "CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity"], "types": ["T044"], "canonical_name": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "definition": "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. [EC:2.4.99.8]"}
{"concept_id": "C1152174", "aliases": ["beta-galactosamide alpha-2,6-sialyltransferase activity", "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity", "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity"], "types": ["T044"], "canonical_name": "beta-galactoside alpha-2,6-sialyltransferase activity", "definition": "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. [EC:2.4.99.1]"}
{"concept_id": "C1152175", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor. [GOC:mengo_curators, PMID:7826016, PMID:8405811]", "canonical_name": "beta-galactoside alpha-2,3-sialyltransferase activity"}
{"concept_id": "C1152176", "aliases": ["alpha2->3 sialyltransferase activity", "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity", "N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "SiaT"], "types": ["T044"], "definition": "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein. [EC:2.4.99.6, RHEA:52316]", "canonical_name": "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity"}
{"concept_id": "C1152177", "aliases": ["neolactotetraosylceramide alpha-2,3-sialyltransferase activity", "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity", "SAT-3"], "types": ["T044"], "definition": "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide. [EC:2.4.99.10]", "canonical_name": "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity"}
{"concept_id": "C1152178", "aliases": ["transferase activity, transferring pentosyl groups"], "types": ["T044"], "definition": "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). [GOC:jl]", "canonical_name": "pentosyltransferase activity"}
{"concept_id": "C1152179", "aliases": ["methylthioadenosine phosphorylase activity", "MTA phosphorylase activity", "MeSAdo phosphorylase activity", "MeSAdo/Ado phosphorylase activity", "methylthioadenosine nucleoside phosphorylase activity", "5'-methylthioadenosine phosphorylase activity", "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity", "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity", "S-methyl-5-thioadenosine phosphorylase activity", "5'-deoxy-5'-methylthioadenosine phosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate. [EC:2.4.2.28]", "canonical_name": "MTAPase activity"}
{"concept_id": "C1152180", "aliases": ["adenine phosphoribosylpyrophosphate transferase activity", "adenylic pyrophosphorylase activity", "AMP-pyrophosphate phosphoribosyltransferase activity", "adenosine phosphoribosyltransferase activity", "AMP diphosphorylase activity", "AMP:diphosphate phospho-D-ribosyltransferase activity", "APRT activity", "adenylate pyrophosphorylase activity", "adenine phosphoribosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.7]", "canonical_name": "AMP pyrophosphorylase activity"}
{"concept_id": "C1152181", "aliases": ["alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity", "phosphoribosyl pyrophosphate amidotransferase activity", "phosphoribosyldiphosphate 5-amidotransferase activity", "5-phosphororibosyl-1-pyrophosphate amidotransferase activity", "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity", "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)", "phosphoribose pyrophosphate amidotransferase activity", "amidophosphoribosyltransferase activity", "5'-phosphoribosylpyrophosphate amidotransferase activity", "phosphoribosylpyrophosphate glutamyl amidotransferase activity", "glutamine phosphoribosyldiphosphate amidotransferase activity", "5-phosphoribosyl-1-pyrophosphate amidotransferase activity", "glutamine phosphoribosylpyrophosphate amidotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O. [EC:2.4.2.14, RHEA:14905]", "canonical_name": "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity"}
{"concept_id": "C1152182", "aliases": ["PRT", "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity", "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity", "phosphoribosylanthranilate transferase activity", "anthranilate phosphoribosyltransferase activity", "phosphoribosylanthranilate pyrophosphorylase activity", "phosphoribosyl-anthranilate pyrophosphorylase activity", "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity", "phosphoribosyl-anthranilate diphosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. [EC:2.4.2.18, RHEA:11768]", "canonical_name": "anthranilate-PP-ribose-P phosphoribosyltransferase activity"}
{"concept_id": "C1152183", "aliases": ["phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity", "ATP phosphoribosyltransferase activity", "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity", "phosphoribosyl-ATP diphosphorylase activity", "phosphoribosyladenosine triphosphate pyrophosphorylase activity", "phosphoribosyladenosine triphosphate synthetase activity", "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity", "phosphoribosyl ATP synthetase activity", "phosphoribosyl-ATP pyrophosphorylase activity", "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.17]", "canonical_name": "adenosine triphosphate phosphoribosyltransferase activity"}
{"concept_id": "C1152185", "aliases": ["inosinic acid pyrophosphorylase activity", "IMP-GMP pyrophosphorylase activity", "IMP:diphosphate phospho-D-ribosyltransferase activity", "IMP pyrophosphorylase activity", "inosinate pyrophosphorylase activity", "inosine 5'-phosphate pyrophosphorylase activity", "inosinic pyrophosphorylase activity", "hypoxanthine phosphoribosyltransferase activity", "IMP diphosphorylase activity", "HPRT"], "types": ["T044"], "definition": "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.8, GOC:curators]", "canonical_name": "HGPRTase activity"}
{"concept_id": "C1152186", "aliases": ["NAD DNA ADP-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "NAD DNA ADP-ribosyltransferase activity", "definition": "Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA. [PMID:27471034, PMID:29361132, PMID:29520010]"}
{"concept_id": "C1152188", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)-asparagine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine. [EC:2.4.2.-]"}
{"concept_id": "C1152189", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)-cysteine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine. [EC:2.4.2.-]"}
{"concept_id": "C1152190", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)-serine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine. [EC:2.4.2.-]"}
{"concept_id": "C1152191", "aliases": ["poly(ADP-ribose)polymerase activity", "poly(adenosine diphosphate ribose) polymerase activity", "poly(ADP-ribose) synthase activity", "NAD ADP-ribosyltransferase activity", "ADP-ribosyltransferase (polymerizing) activity", "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "poly(ADP-ribose) synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30]", "canonical_name": "NAD+ ADP-ribosyltransferase activity"}
{"concept_id": "C1152192", "aliases": ["nicotinic acid phosphoribosyltransferase activity", "nicotinic acid mononucleotide pyrophosphorylase activity", "niacin ribonucleotidase activity", "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity", "nicotinate phosphoribosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate. [PMID:7503993]", "canonical_name": "nicotinic acid mononucleotide glycohydrolase activity"}
{"concept_id": "C1152193", "aliases": ["quinolinic phosphoribosyltransferase activity", "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)", "quinolinate phosphoribosyltransferase (decarboxylating) activity", "nicotinate mononucleotide pyrophosphorylase (carboxylating)", "NAD pyrophosphorylase activity", "nicotinate-nucleotide diphosphorylase (carboxylating) activity", "quinolinic acid phosphoribosyltransferase activity", "QAPRTase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate. [EC:2.4.2.19, RHEA:12733]", "canonical_name": "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity"}
{"concept_id": "C1152194", "aliases": ["N1-alpha-phosphoribosyltransferase activity", "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity", "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity", "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity", "CobT", "nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity", "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity", "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate. [EC:2.4.2.21, RHEA:11196]", "canonical_name": "N(1)-alpha-phosphoribosyltransferase activity"}
{"concept_id": "C1152195", "aliases": ["orotidine-5'-phosphate pyrophosphorylase activity", "orotidine phosphoribosyltransferase activity", "orotidylic acid phosphorylase activity", "orotidylate phosphoribosyltransferase activity", "orotidylic phosphorylase activity", "orotic acid phosphoribosyltransferase activity", "OPRTase activity", "orotate phosphoribosyl pyrophosphate transferase activity", "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity", "orotate phosphoribosyltransferase activity", "orotidine monophosphate pyrophosphorylase activity", "orotidine-5'-phosphate diphosphorylase activity", "orotidylate pyrophosphorylase activity", "orotidylic acid pyrophosphorylase activity", "orotidylic pyrophosphorylase activity", "OPRT activity"], "types": ["T044"], "definition": "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.10]", "canonical_name": "orotidine 5'-monophosphate pyrophosphorylase activity"}
{"concept_id": "C1152196", "aliases": ["purine nucleoside phosphorylase activity", "purine ribonucleoside phosphorylase activity", "PNPase activity", "purine-nucleoside:phosphate ribosyltransferase activity", "PUNPII", "purine-nucleoside phosphorylase activity", "purine deoxyribonucleoside phosphorylase activity", "PUNPI", "inosine-guanosine phosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. [EC:2.4.2.1]", "canonical_name": "purine deoxynucleoside phosphorylase activity"}
{"concept_id": "C1152197", "aliases": ["pyrimidine-nucleoside phosphorylase activity", "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate. [EC:2.4.2.2]", "canonical_name": "Py-NPase activity"}
{"concept_id": "C1152198", "aliases": ["transfer ribonucleate glycosyltransferase activity", "guanine, queuine-tRNA transglycosylase activity", "queuine tRNA-ribosyltransferase activity", "Q-insertase activity", "tRNA transglycosylase activity", "tRNA guanine transglycosidase activity", "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity", "queuine transfer ribonucleate ribosyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. [EC:2.4.2.29]", "canonical_name": "tRNA-guanine transglycosylase activity"}
{"concept_id": "C1152199", "aliases": ["thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity", "thymidine phosphorylase activity", "thymidine-orthophosphate deoxyribosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. [RHEA:16037]", "canonical_name": "thymidine:phosphate deoxy-D-ribosyltransferase activity"}
{"concept_id": "C1152200", "aliases": ["uridine 5'-phosphate pyrophosphorylase activity", "uridine monophosphate pyrophosphorylase activity", "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity", "uridylate pyrophosphorylase activity", "UMP pyrophosphorylase activity", "UMP diphosphorylase activity", "uracil phosphoribosyltransferase activity", "UMP:pyrophosphate phosphoribosyltransferase activity", "uridylic pyrophosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil. [EC:2.4.2.9, RHEA:13017]", "canonical_name": "UPRTase activity"}
{"concept_id": "C1152201", "aliases": ["UPH", "UPase activity", "uridine:phosphate alpha-D-ribosyltransferase activity", "UrdPase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. [EC:2.4.2.3]", "canonical_name": "uridine phosphorylase activity"}
{"concept_id": "C1152203", "aliases": ["Xan phosphoribosyltransferase activity", "xanthine phosphoribosyltransferase activity", "xanthylic pyrophosphorylase activity", "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity", "xanthylate pyrophosphorylase activity", "XMP pyrophosphorylase activity", "xanthosine 5'-phosphate pyrophosphorylase activity", "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate. [EC:2.4.2.22, GOC:clt]", "canonical_name": "xanthine-guanine phosphoribosyltransferase activity"}
{"concept_id": "C1152204", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]", "canonical_name": "xylosyltransferase activity"}
{"concept_id": "C1152205", "aliases": ["UDP-D-xylose:protein beta-D-xylosyltransferase activity", "protein xylosyltransferase activity", "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity", "uridine diphosphoxylose-core protein beta-xylosyltransferase activity", "UDP-D-xylose:core protein beta-D-xylosyltransferase activity", "UDP-D-xylose:core protein xylosyltransferase activity", "UDP-xylose-core protein beta-D-xylosyltransferase activity", "peptide O-xylosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate. [EC:2.4.2.26]", "canonical_name": "uridine diphosphoxylose-protein xylosyltransferase activity"}
{"concept_id": "C1152206", "aliases": [], "types": ["T044"], "canonical_name": "transferase activity, transferring nitrogenous groups", "definition": "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1152208", "aliases": ["transaminase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. [ISBN:0198506732]", "canonical_name": "aminotransferase activity"}
{"concept_id": "C1152209", "aliases": ["aminobutyrate aminotransferase activity", "glutamate-succinic semialdehyde transaminase activity", "4-aminobutyric acid aminotransferase activity", "4-aminobutanoate transaminase activity", "gamma-aminobutyrate transaminase activity", "gamma-aminobutyric acid aminotransferase activity", "gamma-aminobutyric acid transaminase activity", "gamma-aminobutyric transaminase activity", "4-aminobutyrate aminotransferase activity", "4-aminobutyrate transaminase activity", "GABA transaminase activity", "GABA transferase activity", "gamma-amino-N-butyrate transaminase activity", "gamma-aminobutyrate aminotransaminase activity", "aminobutyrate transaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. [GOC:mah]", "canonical_name": "GABA aminotransferase activity"}
{"concept_id": "C1152210", "aliases": [], "types": ["T044"], "canonical_name": "6-aminohexanoate transaminase activity", "definition": "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate. [UM-BBD_reactionID:r0449]"}
{"concept_id": "C1152211", "aliases": ["N-acetylornithine-delta-transaminase activity", "acetylornithine delta-transaminase activity", "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity", "ACOAT activity", "N-acetylornithine aminotransferase activity", "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity", "acetylornithine 5-aminotransferase activity", "acetylornithine transaminase activity", "N2-acetylornithine 5-aminotransferase activity", "N(2)-acetylornithine 5-transaminase activity", "N2-acetylornithine 5-transaminase activity", "acetylornithine aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. [EC:2.6.1.11, RHEA:18049]", "canonical_name": "N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"}
{"concept_id": "C1152212", "aliases": ["adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity", "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity", "7,8-diaminononanoate aminotransferase activity", "DAPA transaminase activity", "7,8-diamino-pelargonic acid aminotransferase activity", "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity", "7,8-diaminonanoate transaminase activity", "7,8-diaminononanoate transaminase activity", "7-keto-8-aminopelargonic acid aminotransferase activity", "diaminopelargonate synthase activity", "adenosylmethionine-8-amino-7-oxononanoate transaminase activity", "7,8-diaminopelargonic acid aminotransferase activity", "adenosyl methionine-8-amino-7-oxononanoate transaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate. [EC:2.6.1.62, RHEA:16861]", "canonical_name": "DAPA aminotransferase activity"}
{"concept_id": "C1152214", "aliases": ["alanine-glyoxylate transaminase activity", "alanine--glyoxylate aminotransferase activity", "L-alanine:glyoxylate aminotransferase activity", "L-alanine-glycine transaminase activity", "alanine-glyoxylate aminotransferase activity", "AGT activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. [EC:2.6.1.44]", "canonical_name": "alanine-glyoxylic aminotransferase activity"}
{"concept_id": "C1152215", "aliases": ["aromatic amino acid aminotransferase activity", "ArAT", "aromatic amino acid transferase activity", "aromatic-amino-acid transaminase activity", "aromatic aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate. [EC:2.6.1.57]", "canonical_name": "aromatic-amino-acid:2-oxoglutarate aminotransferase activity"}
{"concept_id": "C1152217", "aliases": [], "types": ["T044"], "canonical_name": "aspartate-2-keto-4-methylthiobutyrate transaminase activity", "definition": "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate. [MetaCyc:R15-RXN]"}
{"concept_id": "C1152218", "aliases": ["beta-alanine-alpha-alanine transaminase activity", "beta-alanine--pyruvate aminotransferase activity", "beta-alanine-pyruvate transaminase activity", "L-alanine:3-oxopropanoate aminotransferase activity", "omega-amino acid--pyruvate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine. [EC:2.6.1.18]", "canonical_name": "beta-alanine-pyruvate aminotransferase activity"}
{"concept_id": "C1152219", "aliases": ["branched-chain-amino-acid transaminase activity", "glutamate-branched-chain amino acid transaminase activity", "branched-chain amino acid aminotransferase", "branched-chain amino acid aminotransferase activity", "branched-chain aminotransferase activity", "branched-chain amino acid-glutamate transaminase activity", "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. [EC:2.6.1.42, GOC:mah]", "canonical_name": "L-branched chain amino acid aminotransferase activity"}
{"concept_id": "C1152220", "aliases": ["amine-ketoacid transaminase activity", "diamine aminotransferase activity", "diamine-ketoglutaric transaminase activity", "diamine:2-oxoglutarate aminotransferase activity", "diamine transaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate. [EC:2.6.1.29]", "canonical_name": "amine transaminase activity"}
{"concept_id": "C1152221", "aliases": ["L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity", "diaminobutyrate transaminase activity", "L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity", "diaminibutyric acid aminotransferase activity", "diaminobutyrate--2-oxoglutarate aminotransferase activity", "DABA aminotransferase activity", "EctB", "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity", "2,4-diaminobutyrate 4-aminotransferase activity", "DAB aminotransferase activity"], "types": ["T044"], "canonical_name": "diaminobutyrate-2-oxoglutarate transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate. [EC:2.6.1.76, RHEA:11160]"}
{"concept_id": "C1152222", "aliases": ["dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity", "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity", "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity", "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity", "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity", "TDP-4-oxo-6-deoxy-D-glucose transaminase activity", "TDP-4-keto-6-deoxy-D-glucose transaminase activity", "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity"], "types": ["T044"], "canonical_name": "dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity", "definition": "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate. [EC:2.6.1.33]"}
{"concept_id": "C1152225", "aliases": ["L-histidinol-phosphate:2-oxoglutarate aminotransferase activity", "imidazole acetol-phosphate transaminase activity", "histidine:imidazoleacetol phosphate transaminase activity", "histidinol-phosphate transaminase activity", "imidazolylacetolphosphate transaminase activity", "imidazolylacetolphosphate aminotransferase activity", "imidazoleacetol phosphate transaminase activity", "L-histidinol phosphate aminotransferase activity", "IAP transaminase activity", "glutamic-imidazoleacetol phosphate transaminase activity", "histidinol-phosphate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. [EC:2.6.1.9]", "canonical_name": "histidinol phosphate aminotransferase activity"}
{"concept_id": "C1152226", "aliases": ["kynurenine transaminase (cyclizing)", "kynurenine 2-oxoglutarate transaminase activity", "kynurenine-oxoglutarate aminotransferase activity", "kynurenine--oxoglutarate aminotransferase activity", "L-kynurenine aminotransferase activity", "kynurenine-oxoglutarate transaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. [EC:2.6.1.7]", "canonical_name": "L-kynurenine:2-oxoglutarate aminotransferase activity"}
{"concept_id": "C1152227", "aliases": ["lysine 6-aminotransferase activity", "L-lysine 6-transaminase activity", "L-lysine transaminase activity", "L-lysine-alpha-ketoglutarate 6-aminotransferase activity", "L-lysine-alpha-ketoglutarate aminotransferase activity", "L-lysine:2-oxoglutarate 6-aminotransferase activity", "lysine epsilon-transaminase activity", "lysine:2-ketoglutarate 6-aminotransferase activity", "L-lysine aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine. [EC:2.6.1.36, RHEA:21200]", "canonical_name": "lysine epsilon-aminotransferase activity"}
{"concept_id": "C1152228", "aliases": ["ornithine--oxo-acid transaminase activity", "ornithine--oxo acid aminotransferase activity", "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity", "L-ornithine 5-aminotransferase activity", "ornithine:alpha-oxoglutarate transaminase activity", "ornithine-oxo-acid transaminase activity", "ornithine ketoacid aminotransferase activity", "ornithine 5-aminotransferase activity", "GabT", "ornithine--keto acid aminotransferase activity", "ornithine delta-transaminase activity", "ornithine--2-oxoacid aminotransferase activity", "ornithine aminotransferase activity", "ornithine-oxo-acid aminotransferase activity", "ornithine--alpha-ketoglutarate aminotransferase activity", "OAT", "L-ornithine aminotransferase activity", "ornithine--keto acid transaminase activity", "ornithine transaminase activity", "L-ornithine:2-oxo-acid aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. [EC:2.6.1.13]", "canonical_name": "ornithine--ketoglutarate aminotransferase activity"}
{"concept_id": "C1152229", "aliases": ["phosphohydroxypyruvic--glutamic transaminase activity", "PdxC", "phosphoserine transaminase activity", "SerC", "3PHP transaminase activity", "L-phosphoserine aminotransferase activity", "PSAT activity", "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "phosphoserine aminotransferase activity", "O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "3-phosphoserine aminotransferase activity", "hydroxypyruvic phosphate--glutamic transaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. [EC:2.6.1.52]", "canonical_name": "phosphohydroxypyruvate transaminase activity"}
{"concept_id": "C1152231", "aliases": ["pyridoxamine--oxaloacetate aminotransferase activity", "pyridoxamine:oxaloacetate aminotransferase activity", "pyridoxamine-oxaloacetate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal. [EC:2.6.1.31, RHEA:10844]", "canonical_name": "pyridoxamine-oxaloacetate transaminase activity"}
{"concept_id": "C1152232", "aliases": ["pyridoxamine 5'-phosphate transaminase activity", "pyridoxamine-phosphate transaminase activity", "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)", "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity", "pyridoxamine phosphate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate. [EC:2.6.1.54]", "canonical_name": "pyridoxamine-phosphate aminotransferase activity"}
{"concept_id": "C1152233", "aliases": ["hydroxypyruvate:L-alanine transaminase activity", "serine--pyruvate aminotransferase activity", "serine-pyruvate transaminase activity", "serine-pyruvate aminotransferase activity", "L-serine:pyruvate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. [EC:2.6.1.51, RHEA:22852]", "canonical_name": "SPT"}
{"concept_id": "C1152234", "aliases": ["N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity", "succinyldiaminopimelate transaminase activity", "succinyldiaminopimelate aminotransferase activity", "succinyldiaminopimelate transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate. [EC:2.6.1.17, RHEA:11960]", "canonical_name": "N-succinyl-L-diaminopimelic glutamic transaminase activity"}
{"concept_id": "C1152235", "aliases": ["tyrosine aminotransferase activity", "tyrosine transaminase activity"], "types": ["T044"], "canonical_name": "TyrAT activity"}
{"concept_id": "C1152236", "aliases": ["valine--pyruvate aminotransferase activity", "valine-pyruvate transaminase activity", "alanine--valine transaminase activity", "alanine-oxoisovalerate aminotransferase activity", "valine-pyruvate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine. [EC:2.6.1.66, RHEA:22912]", "canonical_name": "L-valine:pyruvate aminotransferase activity"}
{"concept_id": "C1152237", "aliases": [], "types": ["T044"], "canonical_name": "transferase activity, transferring other nitrogenous groups", "definition": "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor). [GOC:ai]"}
{"concept_id": "C1152238", "aliases": [], "types": ["T044"], "canonical_name": "transferase activity, transferring one-carbon groups", "definition": "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1152239", "aliases": ["transamidinase activity"], "types": ["T044"], "definition": "Catalysis of the reversible transfer of an amidino group to an acceptor. [GOC:ai]", "canonical_name": "amidinotransferase activity"}
{"concept_id": "C1152240", "aliases": ["L-arginine:glycine amidinotransferase activity", "glycine transamidinase activity", "arginine-glycine amidinotransferase activity", "glycine amidinotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate. [RHEA:13201]", "canonical_name": "arginine-glycine transamidinase activity"}
{"concept_id": "C1152241", "aliases": ["scyllo-inosamine-4-phosphate amidinotransferase activity", "L-arginine:inosamine phosphate amidinotransferase activity", "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity", "inosamine-phosphate amidinotransferase activity", "L-arginine:inosamine-P-amidinotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine. [RHEA:13265]", "canonical_name": "inosamine-P amidinotransferase activity"}
{"concept_id": "C1152242", "aliases": ["carboxyl- and carbamoyltransferase activity"], "types": ["T044"], "canonical_name": "carboxyl- or carbamoyltransferase activity", "definition": "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). [GOC:jl]"}
{"concept_id": "C1152244", "aliases": ["acetone carboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetone + ATP + CO(2) + 2 H(2)O = acetoacetate + AMP + 4 H(+) + 2 phosphate. [EC:6.4.1.6, RHEA:18385]", "canonical_name": "acetone:carbon-dioxide ligase (AMP-forming)"}
{"concept_id": "C1152245", "aliases": ["aspartate carbamyltransferase activity", "L-aspartate transcarbamoylase activity", "carbamylaspartotranskinase activity", "L-aspartate transcarbamylase activity", "aspartic acid transcarbamoylase activity", "ATCase activity", "aspartic transcarbamylase activity", "aspartate carbamoyltransferase activity", "aspartate transcarbamoylase activity", "aspartate transcarbamylase activity", "aspartic carbamyltransferase activity", "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. [EC:2.1.3.2, RHEA:20013]", "canonical_name": "carbamoylaspartotranskinase activity"}
{"concept_id": "C1152246", "aliases": ["ornithine carbamyltransferase activity", "carbamylphosphate-ornithine transcarbamylase activity", "citrulline phosphorylase activity", "L-ornithine carbamoyltransferase activity", "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity", "L-ornithine carbamyltransferase activity", "ornithine transcarbamylase activity", "L-ornithine transcarbamylase activity", "OTC activity", "ornithine carbamoyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. [EC:2.1.3.3]", "canonical_name": "OTCase activity"}
{"concept_id": "C1152247", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a methyl group to an acceptor molecule. [ISBN:0198506732]", "canonical_name": "methyltransferase activity"}
{"concept_id": "C1152248", "aliases": [], "types": ["T044"], "canonical_name": "1-phenanthrol methyltransferase activity", "definition": "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene. [UM-BBD_reactionID:r0493]"}
{"concept_id": "C1152249", "aliases": [], "types": ["T044"], "canonical_name": "5,10-methylenetetrahydrofolate-dependent methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate. [GOC:ai]"}
{"concept_id": "C1152250", "aliases": ["dTMP synthase activity", "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity", "thymidylate synthase activity", "methylenetetrahydrofolate:dUMP C-methyltransferase activity", "TMP synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. [EC:2.1.1.45, RHEA:12104]", "canonical_name": "thymidylate synthetase activity"}
{"concept_id": "C1152251", "aliases": [], "types": ["T044"], "canonical_name": "5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin. [GOC:ai]"}
{"concept_id": "C1152252", "aliases": ["tetrahydromethanopterin methyltransferase activity", "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity", "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity", "tetrahydromethanopterin S-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM. [EC:2.1.1.86, RHEA:53492]", "canonical_name": "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity"}
{"concept_id": "C1152254", "aliases": ["N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity", "cobalamin-dependent methionine synthase activity", "N(5)-methyltetrahydrofolate methyltransferase activity", "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity", "vitamin B12 methyltransferase activity", "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity", "methionine synthase (cobalamin-dependent) activity", "N5-methyltetrahydrofolate methyltransferase activity", "tetrahydropteroylglutamic methyltransferase activity", "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity", "tetrahydrofolate methyltransferase activity", "tetrahydropteroylglutamate methyltransferase activity", "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity", "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity", "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity", "MetH", "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity", "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity", "5-methyltetrahydrofolate--homocysteine transmethylase activity", "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity", "methionine synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine. [EC:2.1.1.13, RHEA:11172]", "canonical_name": "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity"}
{"concept_id": "C1152255", "aliases": [], "types": ["T044"], "canonical_name": "5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate. [GOC:ai]"}
{"concept_id": "C1152256", "aliases": ["homocysteine methylase activity", "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity", "methionine synthase (cobalamin-independent) activity", "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity", "5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity", "cobalamin-independent methionine synthase activity", "MetE", "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity", "tetrahydropteroylglutamate-homocysteine transmethylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. [EC:2.1.1.14, RHEA:21196]", "canonical_name": "tetrahydropteroyltriglutamate methyltransferase activity"}
{"concept_id": "C1152257", "aliases": ["protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity", "T-protein", "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity", "aminomethyltransferase activity", "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. [EC:2.1.2.10]", "canonical_name": "tetrahydrofolate aminomethyltransferase activity"}
{"concept_id": "C1152258", "aliases": [], "types": ["T044"], "canonical_name": "C-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152259", "aliases": ["delta(24)-sterol C-methyltransferase activity", "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity", "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity", "delta(24)-methyltransferase activity", "24-sterol C-methyltransferase activity", "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity", "delta(24)-sterol methyltransferase activity", "delta24-methyltransferase activity", "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity", "sterol 24C methyltransferase activity", "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity", "delta24-sterol methyltransferase activity"], "types": ["T044"], "canonical_name": "sterol 24-C-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol. [RHEA:21128]"}
{"concept_id": "C1152260", "aliases": [], "types": ["T044"], "canonical_name": "quinone cofactor methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1). [GOC:mb]"}
{"concept_id": "C1152261", "aliases": ["coenzyme Q biosynthesis methyltransferase activity", "coenzyme Q biosynthetic process methyltransferase activity", "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity"], "types": ["T044"], "canonical_name": "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "definition": "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. [GOC:kd, PMID:9083048]"}
{"concept_id": "C1152262", "aliases": ["uroporphyrinogen-III methyltransferase activity", "CobA", "uroporphyrinogen-III methylase activity", "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity", "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity", "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity", "adenosylmethionine-uroporphyrinogen III methyltransferase activity", "SirA", "urogen III methylase activity", "CysG", "SUMT activity", "uroporphyrinogen-III C-methyltransferase activity", "uroporphyrin-III C-methyltransferase activity", "uroporphyrinogen III methylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2. [EC:2.1.1.107]", "canonical_name": "uroporphyrinogen methyltransferase activity"}
{"concept_id": "C1152263", "aliases": ["cyclopropane fatty acid synthetase activity", "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)", "cyclopropane-fatty-acyl-phospholipid synthase activity", "CFA synthase activity", "cyclopropane synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. [EC:2.1.1.79]", "canonical_name": "cyclopropane fatty acid synthase activity"}
{"concept_id": "C1152264", "aliases": ["S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity", "diphthine synthase activity", "diphthine methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. [PMID:15485916, PMID:20873788, PMID:3042777]", "canonical_name": "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity"}
{"concept_id": "C1152265", "aliases": ["deoxyribonucleic acid (cytosine-5-)-methyltransferase activity", "DNA cytosine C(5) methylase activity", "DNA cytosine C5 methylase activity", "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity", "cytosine 5-methyltransferase activity", "DNA 5-cytosine methylase activity", "DNA-cytosine 5-methylase activity", "cytosine DNA methyltransferase activity", "cytosine-specific DNA methyltransferase activity", "deoxyribonucleic (cytosine-5-)-methyltransferase activity", "DNA (cytosine-5-)-methyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. [EC:2.1.1.37]", "canonical_name": "DNA-cytosine methyltransferase activity"}
{"concept_id": "C1152266", "aliases": ["deoxyribonucleate methyltransferase activity", "deoxyribonucleic acid methylase activity", "deoxyribonucleic acid methyltransferase activity", "DNA transmethylase activity", "DNA methyltransferase activity", "deoxyribonucleate methylase activity"], "types": ["T045"], "canonical_name": "DNA-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to a DNA molecule. [GOC:jl, ISBN:0198506732, PMID:7862522]"}
{"concept_id": "C1152267", "aliases": ["N-6 adenine-specific DNA methylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. [EC:2.1.1.72]", "canonical_name": "site-specific DNA-methyltransferase (adenine-specific) activity"}
{"concept_id": "C1152268", "aliases": ["S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity", "N(4)-cytosine-specific DNA methylase activity", "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity", "site-specific DNA-methyltransferase (cytosine-N4-specific) activity", "m4C-forming MTase activity", "N4-cytosine-specific DNA methylase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine. [EC:2.1.1.113]", "canonical_name": "DNA[cytosine-N4]methyltransferase activity"}
{"concept_id": "C1152269", "aliases": [], "types": ["T045"], "canonical_name": "site-specific DNA-methyltransferase (cytosine-specific) activity"}
{"concept_id": "C1152270", "aliases": ["serine hydroxymethyltransferase activity", "glycine hydroxymethyltransferase activity", "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity", "serine hydroxymethylase activity", "serine aldolase activity", "L-serine hydroxymethyltransferase activity", "serine transhydroxymethylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. [RHEA:15481]", "canonical_name": "allothreonine aldolase activity"}
{"concept_id": "C1152271", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethyl-, formyl- and related transferase activity", "definition": "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). [EC:2.1.2.-, GOC:mah]"}
{"concept_id": "C1152272", "aliases": ["ketopantoate hydroxymethyltransferase activity", "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity", "oxopantoate hydroxymethyltransferase activity", "alpha-ketoisovalerate hydroxymethyltransferase activity", "3-methyl-2-oxobutanoate hydroxymethyltransferase activity", "dehydropantoate hydroxymethyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. [EC:2.1.2.11]", "canonical_name": "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"}
{"concept_id": "C1152274", "aliases": ["glutamate formimidoyltransferase activity", "glutamate formyltransferase activity", "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity", "glutamate formiminotransferase activity", "formiminoglutamic formiminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. [RHEA:15097]", "canonical_name": "formiminoglutamic acid transferase activity"}
{"concept_id": "C1152275", "aliases": ["glycine formimidoyltransferase activity", "FIG formiminotransferase activity", "glycine formiminotransferase activity", "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine. [RHEA:24288]", "canonical_name": "formiminoglycine formiminotransferase activity"}
{"concept_id": "C1152276", "aliases": ["methionyl-transfer RNA transformylase activity", "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity", "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity", "methionyl-transfer ribonucleic transformylase activity", "formylmethionyl-transfer ribonucleic synthetase activity", "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity", "methionyl-tRNA Met formyltransferase activity", "methionyl-tRNA transformylase activity", "methionyl-tRNA formyltransferase activity", "methionyl ribonucleic formyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. [EC:2.1.2.9]", "canonical_name": "conversion of met-tRNAf to fmet-tRNA"}
{"concept_id": "C1152277", "aliases": ["AICAR formyltransferase activity", "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity", "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity", "aminoimidazolecarboxamide ribonucleotide transformylase activity", "AICAR transformylase activity", "5-amino-4-imidazolecarboxamide ribotide transformylase activity", "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity", "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity", "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity"], "types": ["T044"], "canonical_name": "phosphoribosylaminoimidazolecarboxamide formyltransferase activity", "definition": "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. [EC:2.1.2.3]"}
{"concept_id": "C1152278", "aliases": ["5'-phosphoribosylglycinamide transformylase activity", "phosphoribosylglycinamide formyltransferase activity", "GAR transformylase activity", "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity", "glycinamide ribonucleotide transformylase activity", "GAR formyltransferase activity", "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity", "GART activity", "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. [EC:2.1.2.2]", "canonical_name": "GAR TFase activity"}
{"concept_id": "C1152279", "aliases": ["S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity", "DHHB-Mt activity", "hexaprenyldihydroxybenzoate methyltransferase activity", "dihydroxyhexaprenylbenzoate methyltransferase activity", "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate. [EC:2.1.1.114]", "canonical_name": "DHHB methyltransferase activity"}
{"concept_id": "C1152280", "aliases": ["histone methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. [GOC:curators]", "canonical_name": "histone methylase activity"}
{"concept_id": "C1152281", "aliases": ["S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)"], "types": ["T044"], "canonical_name": "methylene-fatty-acyl-phospholipid synthase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid. [EC:2.1.1.16]"}
{"concept_id": "C1152282", "aliases": [], "types": ["T044"], "canonical_name": "N-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152284", "aliases": [], "types": ["T044"], "canonical_name": "arginine N-methyltransferase activity", "definition": "Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue. [GOC:mah]"}
{"concept_id": "C1152285", "aliases": ["PRMT activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. [GOC:mah, PMID:12351636, PMID:31284549]", "canonical_name": "protein-arginine N-methyltransferase activity"}
{"concept_id": "C1152286", "aliases": ["nuclear protein (histone) N-methyltransferase activity", "histone-arginine N-methyltransferase activity", "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity", "histone-arginine N-methylase activity", "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine. [PMID:8002954]", "canonical_name": "histone protein methylase activity"}
{"concept_id": "C1152287", "aliases": ["cytochrome c-arginine N-methyltransferase activity"], "types": ["T044"], "canonical_name": "[cytochrome c]-arginine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine. [EC:2.1.1.124, GOC:ma]"}
{"concept_id": "C1152288", "aliases": ["S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity", "S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity", "myelin basic protein methylase activity", "[myelin basic protein]-arginine N-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine. [PMID:6177833]", "canonical_name": "myelin basic protein-arginine N-methyltransferase activity"}
{"concept_id": "C1152289", "aliases": ["type IV protein arginine methyltransferase activity", "type IV PRMT activity", "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)", "protein-arginine delta-N-methyltransferase activity"], "types": ["T044"], "canonical_name": "protein-arginine N5-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine. [EC:2.1.1.322, PMID:9873020]"}
{"concept_id": "C1152290", "aliases": ["GNMT", "glycine methyltransferase activity", "glycine N-methyltransferase activity", "S-adenosyl-L-methionine:glycine methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. [EC:2.1.1.20]", "canonical_name": "S-adenosyl-L-methionine:glycine N-methyltransferase activity"}
{"concept_id": "C1152291", "aliases": ["histamine 1-methyltransferase activity", "histamine methyltransferase activity", "histamine N-methyltransferase activity", "imidazolemethyltransferase activity", "S-adenosylmethionine-histamine N-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.8, RHEA:19301]", "canonical_name": "S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity"}
{"concept_id": "C1152292", "aliases": [], "types": ["T044"], "canonical_name": "lysine N-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. [GOC:mah]"}
{"concept_id": "C1152293", "aliases": [], "types": ["T044"], "canonical_name": "protein-lysine N-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. [PMID:12054878]"}
{"concept_id": "C1152294", "aliases": ["S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity", "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity", "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity"], "types": ["T044"], "canonical_name": "calmodulin-lysine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine. [EC:2.1.1.60]"}
{"concept_id": "C1152295", "aliases": ["histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity", "histone-lysine N-methylase activity", "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity", "histone-lysine N-methyltransferase activity", "protein (lysine) methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. [RHEA:10024]", "canonical_name": "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity"}
{"concept_id": "C1152296", "aliases": ["S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity", "cytochrome c (lysine) methyltransferase activity", "cytochrome c methyltransferase activity", "cytochrome c-specific protein-lysine methyltransferase activity", "cytochrome c-specific protein methylase III activity", "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity", "cytochrome c-lysine N-methyltransferase activity"], "types": ["T044"], "canonical_name": "[cytochrome c]-lysine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c. [EC:2.1.1.59]"}
{"concept_id": "C1152297", "aliases": ["messenger ribonucleate guanine 7-methyltransferase activity", "mRNA (guanine-N7-)-methyltransferase activity", "guanine-7-methyltransferase activity", "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity", "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. [EC:2.1.1.56]", "canonical_name": "messenger RNA guanine 7-methyltransferase activity"}
{"concept_id": "C1152298", "aliases": ["nicotinamide methyltransferase activity", "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity"], "types": ["T044"], "canonical_name": "nicotinamide N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. [EC:2.1.1.1, RHEA:23884]"}
{"concept_id": "C1152299", "aliases": ["S-adenosyl-L-methionine:nicotinate N-methyltransferase activity", "furanocoumarin 8-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "nicotinate N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine. [EC:2.1.1.7, RHEA:20241]"}
{"concept_id": "C1152300", "aliases": ["S-adenosyl methionine:protein-histidine N-methyltransferase activity", "protein-histidine N-methyltransferase activity", "peptidyl-histidine N-methyltransferase activity", "protein (histidine) methyltransferase activity", "actin-specific histidine methyltransferase activity", "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity"], "types": ["T044"], "canonical_name": "protein-L-histidine N-tele-methyltransferase activity", "definition": "Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine. [RHEA:19369]"}
{"concept_id": "C1152301", "aliases": ["norepinephrine methyltransferase activity", "noradrenaline N-methyltransferase activity", "phenethanolamine N-methyltransferase activity", "phenylethanolamine N-methyltransferase activity", "norepinephrine N-methyltransferase activity", "noradrenalin N-methyltransferase activity", "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine. [EC:2.1.1.28]", "canonical_name": "phenethanolamine methyltransferase activity"}
{"concept_id": "C1152302", "aliases": ["phosphatidylethanolamine methyltransferase activity", "phosphatidylethanolamine N-methyltransferase activity", "LMTase activity", "lipid methyl transferase activity", "phosphatidylethanolamine-N-methylase activity", "PEMT", "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine. [EC:2.1.1.17, RHEA:11164]", "canonical_name": "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity"}
{"concept_id": "C1152303", "aliases": ["phosphoethanolamine methyltransferase activity", "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate. [EC:2.1.1.103]", "canonical_name": "phosphoethanolamine N-methyltransferase activity"}
{"concept_id": "C1152304", "aliases": ["S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity", "N(2),N(2)-dimethylguanine tRNA methyltransferase activity", "tRNA(guanine-26,N2-N2) methyltransferase activity", "guanine-N2-methylase activity", "tRNA 2,2-dimethylguanosine-26 methyltransferase activity", "tRNA (guanine-N2-)-methyltransferase activity", "transfer ribonucleate guanine N2-methyltransferase activity", "transfer ribonucleate guanine 2-methyltransferase activity", "tRNA(m(2,2)G26)dimethyltransferase activity", "transfer RNA guanine 2-methyltransferase activity", "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity", "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. [EC:2.1.1.32]", "canonical_name": "N2,N2-dimethylguanine tRNA methyltransferase activity"}
{"concept_id": "C1152305", "aliases": [], "types": ["T044"], "canonical_name": "O-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152306", "aliases": ["5-demethylubiquinone-9 methyltransferase activity", "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity", "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity", "OMHMB-methyltransferase activity"], "types": ["T044"], "canonical_name": "3-demethylubiquinone-9 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9. [GOC:dph]"}
{"concept_id": "C1152307", "aliases": ["hydroxyindole methyltransferase activity", "N-acetylserotonin O-methyltransferase activity", "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity", "acetylserotonin methyltransferase activity", "hydroxyindole O-methyltransferase activity"], "types": ["T044"], "canonical_name": "acetylserotonin O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine. [EC:2.1.1.4]"}
{"concept_id": "C1152308", "aliases": ["caffeoyl coenzyme A methyltransferase activity", "caffeoyl-CoA O-methyltransferase activity", "S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity", "trans-caffeoyl-CoA 3-O-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA. [EC:2.1.1.104]", "canonical_name": "caffeoyl-CoA 3-O-methyltransferase activity"}
{"concept_id": "C1152309", "aliases": ["catechol methyltransferase activity", "COMT I", "COMT II", "catecholamine O-methyltransferase activity", "S-adenosyl-L-methionine:catechol O-methyltransferase activity", "catechol O-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. [EC:2.1.1.6]", "canonical_name": "S-COMT (soluble form of catechol-O-methyltransferase)"}
{"concept_id": "C1152310", "aliases": ["farnesoic acid O-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine. [PMID:12135499]", "canonical_name": "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity"}
{"concept_id": "C1152311", "aliases": ["(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity", "S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity", "Mg-protoporphyrin IX methyltransferase activity", "S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity", "S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity", "magnesium-protoporphyrin O-methyltransferase activity", "S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity", "S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity"], "types": ["T044"], "canonical_name": "magnesium protoporphyrin IX methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H(+) + magnesium protoporphyrin IX 13-monomethyl ester. [EC:2.1.1.11, RHEA:17809]"}
{"concept_id": "C1152312", "aliases": ["messenger RNA (nucleoside-2'-)-methyltransferase activity", "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity", "mRNA (adenosine-2'-O-)-methyltransferase activity", "messenger ribonucleate nucleoside 2'-methyltransferase activity"], "types": ["T045"], "canonical_name": "mRNA (nucleoside-2'-O-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine. [EC:2.1.1.57]"}
{"concept_id": "C1152313", "aliases": ["protein(carboxyl)methyltransferase activity", "protein carboxymethylase activity", "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity", "protein carboxymethyltransferase activity", "methyl-accepting chemotaxis protein methyltransferase II", "methyl-accepting chemotaxis protein O-methyltransferase activity", "protein carboxylmethyltransferase II", "protein methylase II", "MCP methyltransferase I", "protein(aspartate)methyltransferase activity", "S-adenosylmethionine-glutamyl methyltransferase activity", "MCP methyltransferase II", "protein O-methyltransferase activity", "protein-glutamate O-methyltransferase activity", "protein carboxyl-O-methyltransferase activity", "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester. [EC:2.1.1.80, RESID:AA0072]", "canonical_name": "protein carboxyl-methylase activity"}
{"concept_id": "C1152314", "aliases": ["L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity", "protein L-isoaspartate methyltransferase activity", "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity", "protein-beta-aspartate O-methyltransferase activity", "protein-L-isoaspartate O-methyltransferase activity", "L-isoaspartyl protein carboxyl methyltransferase activity", "L-aspartyl/L-isoaspartyl protein methyltransferase activity", "protein (D-aspartate) methyltransferase activity", "protein L-isoaspartyl methyltransferase activity", "protein D-aspartate methyltransferase activity", "D-aspartyl/L-isoaspartyl methyltransferase activity", "protein beta-aspartate O-methyltransferase activity", "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity", "protein O-methyltransferase (L-isoaspartate)"], "types": ["T044"], "canonical_name": "protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. [EC:2.1.1.77]"}
{"concept_id": "C1152315", "aliases": ["protein-leucine O-methyltransferase activity"], "types": ["T044"], "canonical_name": "protein C-terminal leucine carboxyl O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein. [PMID:8514774]"}
{"concept_id": "C1152317", "aliases": ["CobM", "S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5. [EC:2.1.1.133]", "canonical_name": "precorrin-4 C11-methyltransferase activity"}
{"concept_id": "C1152318", "aliases": ["S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)", "precorrin-6 methyltransferase", "precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2. [EC:2.1.1.132]", "canonical_name": "precorrin-6Y methylase"}
{"concept_id": "C1152319", "aliases": [], "types": ["T044"], "canonical_name": "protein methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group (CH3-) to a protein. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1152320", "aliases": ["C-terminal protein carboxyl methyltransferase activity"], "types": ["T044"], "canonical_name": "protein C-terminal carboxyl O-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. [PMID:8428937]"}
{"concept_id": "C1152321", "aliases": ["SAM-dependent methyltransferase activity", "S-adenosyl methionine-dependent methyltransferase activity"], "types": ["T044"], "canonical_name": "S-adenosylmethionine-dependent methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. [GOC:mah]"}
{"concept_id": "C1152322", "aliases": ["S-adenosylmethionine:homocysteine methyltransferase activity", "adenosylmethionine:homocysteine methyltransferase activity", "S-adenosylmethionine homocysteine transmethylase activity", "S-adenosylmethionine-homocysteine transmethylase activity", "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity", "adenosylmethionine transmethylase activity", "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity"], "types": ["T044"], "canonical_name": "S-adenosylmethionine-homocysteine S-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine. [EC:2.1.1.10, GOC:BHF, GOC:dph]"}
{"concept_id": "C1152323", "aliases": [], "types": ["T044"], "canonical_name": "RNA methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. [GOC:mah]"}
{"concept_id": "C1152324", "aliases": [], "types": ["T045"], "canonical_name": "mRNA methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. [GOC:mah]"}
{"concept_id": "C1152325", "aliases": ["messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity", "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity", "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. [EC:2.1.1.62]", "canonical_name": "mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"}
{"concept_id": "C1152326", "aliases": [], "types": ["T045"], "canonical_name": "rRNA methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. [GOC:mah]"}
{"concept_id": "C1152327", "aliases": [], "types": ["T045"], "canonical_name": "rRNA (adenine) methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. [GOC:go-curators]"}
{"concept_id": "C1152328", "aliases": ["18S rRNA dimethylase activity", "dimethyladenosine transferase activity", "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity"], "types": ["T045"], "canonical_name": "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "definition": "Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor. [ISBN:1555811337, PMID:10690410]"}
{"concept_id": "C1152329", "aliases": ["ribosomal ribonucleate adenine 6-methyltransferase activity", "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity", "ribonucleic acid-adenine (N6) methylase activity", "ribonucleic acid-adenine (N(6)) methylase activity", "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity"], "types": ["T045"], "canonical_name": "rRNA (adenine-N6-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine. [EC:2.1.1.48]"}
{"concept_id": "C1152330", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (cytosine) methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine. [GOC:go-curators]"}
{"concept_id": "C1152331", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (cytosine-C5-967)-methyltransferase activity"}
{"concept_id": "C1152332", "aliases": [], "types": ["T045"], "canonical_name": "rRNA (guanine) methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine. [EC:2.1.1.-]"}
{"concept_id": "C1152333", "aliases": ["ribosomal ribonucleate guanine 1-methyltransferase activity", "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity", "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity"], "types": ["T045"], "canonical_name": "rRNA (guanine-N1-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine. [GOC:curators]"}
{"concept_id": "C1152334", "aliases": ["S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity", "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity", "ribosomal ribonucleate guanine-2-methyltransferase activity"], "types": ["T045"], "canonical_name": "rRNA (guanine-N2-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. [EC:2.1.1.52]"}
{"concept_id": "C1152335", "aliases": [], "types": ["T045"], "canonical_name": "rRNA (uridine) methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine. [GOC:go-curators]"}
{"concept_id": "C1152336", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (uridine-2'-O-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. [GOC:mah]"}
{"concept_id": "C1152337", "aliases": [], "types": ["T045"], "canonical_name": "tRNA methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. [GOC:mah]"}
{"concept_id": "C1152338", "aliases": ["S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity", "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity", "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity"], "types": ["T045"], "canonical_name": "tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. [EC:2.1.1.61, GOC:imk]"}
{"concept_id": "C1152339", "aliases": [], "types": ["T045"], "canonical_name": "tRNA (adenine) methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine. [GOC:go-curators]"}
{"concept_id": "C1152340", "aliases": ["adenine-1-methylase activity", "transfer ribonucleate adenine 1-methyltransferase activity", "1-methyladenine transfer RNA methyltransferase activity", "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity", "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity", "transfer RNA (adenine-1) methyltransferase activity"], "types": ["T045"], "canonical_name": "tRNA (adenine-N1-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. [EC:2.1.1.36]"}
{"concept_id": "C1152341", "aliases": ["S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity", "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity"], "types": ["T045"], "canonical_name": "tRNA (adenine-N6-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine. [EC:2.1.1.55]"}
{"concept_id": "C1152342", "aliases": [], "types": ["T045"], "canonical_name": "tRNA (cytosine) methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine. [GOC:go-curators]"}
{"concept_id": "C1152343", "aliases": ["S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity", "transfer ribonucleate cytosine 5-methyltransferase activity", "transfer RNA cytosine 5-methyltransferase activity"], "types": ["T045"], "canonical_name": "tRNA (cytosine-5-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine. [EC:2.1.1.29]"}
{"concept_id": "C1152344", "aliases": ["tRNA (guanosine) methyltransferase activity"], "types": ["T045"], "canonical_name": "tRNA (guanine) methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine. [GOC:go-curators]"}
{"concept_id": "C1152345", "aliases": ["S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity", "transfer ribonucleate guanine 1-methyltransferase activity", "tRNA guanine 1-methyltransferase activity", "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. [EC:2.1.1.31]", "canonical_name": "tRNA (guanine-N1-)-methyltransferase activity"}
{"concept_id": "C1152346", "aliases": ["7-methylguanine transfer ribonucleate methylase activity", "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity", "tRNA (guanine-N7-)-methyltransferase activity", "N7-methylguanine methylase activity", "transfer ribonucleate guanine 7-methyltransferase activity", "tRNA guanine 7-methyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. [EC:2.1.1.33]", "canonical_name": "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity"}
{"concept_id": "C1152348", "aliases": ["tRNA guanosine 2'-methyltransferase activity", "tRNA (guanosine-2'-O-)-methyltransferase activity", "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity", "tRNA (Gm18) methyltransferase activity", "tRNA guanosine-2'-O-methyltransferase activity", "tRNA (Gm18) 2'-O-methyltransferase activity", "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity", "transfer ribonucleate guanosine 2'-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine. [EC:2.1.1.34, RHEA:20077]", "canonical_name": "tRNA (guanosine 2')-methyltransferase activity"}
{"concept_id": "C1152349", "aliases": ["tRNA (uridine) methyltransferase activity"], "types": ["T044"], "canonical_name": "tRNA (uracil) methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. [GOC:mah]"}
{"concept_id": "C1152353", "aliases": ["S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity", "S-adenosyl-L-methionine:thioether S-methyltransferase activity", "thioether methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium. [EC:2.1.1.96, RHEA:19613]", "canonical_name": "thioether S-methyltransferase activity"}
{"concept_id": "C1152354", "aliases": ["thiol S-methyltransferase activity", "TMT", "thiol methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether. [EC:2.1.1.9]", "canonical_name": "S-adenosyl-L-methionine:thiol S-methyltransferase activity"}
{"concept_id": "C1152355", "aliases": ["TPMT", "thiopurine S-methyltransferase activity", "mercaptopurine methyltransferase activity", "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity", "6-thiopurine transmethylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. [EC:2.1.1.67]", "canonical_name": "thiopurine methyltransferase activity"}
{"concept_id": "C1152356", "aliases": [], "types": ["T044"], "canonical_name": "S-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1152357", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine. [EC:2.1.1.280, PMID:10026151]", "canonical_name": "selenocysteine methyltransferase activity"}
{"concept_id": "C1152358", "aliases": ["S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "trans-aconitate 3-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine. [EC:2.1.1.145, RHEA:22200]"}
{"concept_id": "C1152359", "aliases": ["methionine synthase cob(II)alamin reductase (methylating) activity", "[methionine synthase] reductase activity", "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity", "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)", "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+. [RHEA:23908]", "canonical_name": "methionine synthase reductase activity"}
{"concept_id": "C1152360", "aliases": [], "types": ["T044"], "canonical_name": "transferase activity, transferring phosphorus-containing groups", "definition": "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1152361", "aliases": [], "types": ["T044"], "canonical_name": "deoxycytidyl transferase activity, template-dependent"}
{"concept_id": "C1152363", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). [GOC:jl, PMID:1651917]", "canonical_name": "diphosphotransferase activity"}
{"concept_id": "C1152364", "aliases": ["inositol phosphoceramide synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol. [PMID:9405490, PMID:9614099]", "canonical_name": "IPC synthase activity"}
{"concept_id": "C1152365", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732]", "canonical_name": "nucleotidyltransferase activity"}
{"concept_id": "C1152366", "aliases": ["3-deoxy-manno-octulosonate cytidylyltransferase activity", "CMP-3-deoxy-D-manno-octulosonate synthetase activity", "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity", "CMP-KDO synthetase activity", "2-keto-3-deoxyoctonate cytidylyltransferase activity", "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity", "3-deoxy-D-manno-octulosonate cytidylyltransferase activity", "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity", "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity", "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity", "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. [EC:2.7.7.38]", "canonical_name": "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity"}
{"concept_id": "C1152367", "aliases": ["acylneuraminate cytidyltransferase activity", "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity", "cytidine monophosphosialate pyrophosphorylase activity", "CMP-NANA synthetase activity", "CMP-sialate diphosphorylase activity", "acetylneuraminate cytidylyltransferase activity", "CMP-N-acetylneuraminic acid synthetase activity", "cytidine monophosphosialic acid synthetase activity", "CMP-NeuNAc synthetase activity", "CMP-sialate synthase activity", "cytidine monophosphosialate synthetase activity", "CMP-sialate synthetase activity", "CMP-N-acetylneuraminate synthetase activity", "CTP:N-acylneuraminate cytidylyltransferase activity", "CMP-NeuAc synthetase activity", "cytidine monophosphoacetylneuraminic synthetase activity", "CMP-sialic synthetase activity", "CMP-N-acetylneuraminate synthase activity", "CMP-Neu5Ac synthetase activity", "CMP-N-acetylneuraminic acid synthase activity", "N-acylneuraminate cytidylyltransferase activity", "cytidine 5'-monophosphosialic acid synthetase activity", "CMP-sialate pyrophosphorylase activity", "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. [EC:2.7.7.43]", "canonical_name": "CMP-sialic acid synthetase activity"}
{"concept_id": "C1152368", "aliases": ["adenine triphosphate adenylyltransferase activity", "diadenosinetetraphosphate alphabeta-phosphorylase activity", "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity", "ATP adenylyltransferase activity", "ADP:ATP adenylyltransferase activity", "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity", "dinucleoside oligophosphate alphabeta-phosphorylase activity", "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity", "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)", "diadenosinetetraphosphate alpha-beta-phosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate. [EC:2.7.7.53]", "canonical_name": "AP-4-A phosphorylase activity"}
{"concept_id": "C1152369", "aliases": ["cytidine diphosphocholine pyrophosphorylase activity", "CTP:choline-phosphate cytidylyltransferase activity", "CDP-choline synthetase activity", "phosphocholine cytidylyltransferase activity", "CTP-phosphocholine cytidylyltransferase activity", "phosphorylcholine:CTP cytidylyltransferase activity", "CTP:phosphorylcholine cytidylyltransferase activity", "CDP-choline pyrophosphorylase activity", "phosphorylcholine cytidylyltransferase activity", "phosphorylcholine transferase activity", "choline-phosphate cytidylyltransferase activity", "choline phosphate cytidylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. [EC:2.7.7.15]", "canonical_name": "CTP:phosphocholine cytidylyltransferase activity"}
{"concept_id": "C1152370", "aliases": ["nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity", "DNA nucleotidylexotransferase activity", "deoxyribonucleic nucleotidyltransferase activity", "terminal deoxyribonucleotidyltransferase activity", "terminal deoxynucleotide transferase activity", "deoxyribonucleic acid nucleotidyltransferase activity", "addase activity", "terminal transferase activity", "deoxynucleotidyl terminal transferase activity", "TdT"], "types": ["T045"], "definition": "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). [EC:2.7.7.31]", "canonical_name": "terminal deoxynucleotidyltransferase activity"}
{"concept_id": "C1152371", "aliases": ["DNA duplicase activity", "deoxyribonucleic acid duplicase activity", "deoxyribonucleic duplicase activity", "DNA-directed DNA polymerase activity", "DNA nucleotidyltransferase (DNA-directed) activity", "DNA-dependent DNA polymerase activity", "DNA replicase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. [EC:2.7.7.7, GOC:vw, ISBN:0198547684]", "canonical_name": "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity"}
{"concept_id": "C1152372", "aliases": ["alpha DNA polymerase activity"], "types": ["T045"], "canonical_name": "DNA polymerase alpha"}
{"concept_id": "C1152373", "aliases": ["DNA polymerase beta"], "types": ["T045"], "canonical_name": "beta DNA polymerase activity"}
{"concept_id": "C1152374", "aliases": [], "types": ["T045"], "canonical_name": "delta DNA polymerase activity"}
{"concept_id": "C1152375", "aliases": ["DNA polymerase processivity factor activity", "sliding clamp"], "types": ["T045"], "definition": "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. [GOC:mah, PMID:7903401, PMID:8087839]", "canonical_name": "processivity clamp"}
{"concept_id": "C1152376", "aliases": [], "types": ["T045"], "canonical_name": "DNA polymerase V activity"}
{"concept_id": "C1152377", "aliases": [], "types": ["T045"], "canonical_name": "epsilon DNA polymerase activity"}
{"concept_id": "C1152378", "aliases": [], "types": ["T045"], "canonical_name": "eta DNA polymerase activity"}
{"concept_id": "C1152379", "aliases": [], "types": ["T045"], "canonical_name": "gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C1152380", "aliases": [], "types": ["T045"], "canonical_name": "iota DNA polymerase activity"}
{"concept_id": "C1152381", "aliases": [], "types": ["T045"], "canonical_name": "kappa DNA polymerase activity"}
{"concept_id": "C1152382", "aliases": [], "types": ["T045"], "canonical_name": "lambda DNA polymerase activity"}
{"concept_id": "C1152383", "aliases": [], "types": ["T045"], "canonical_name": "mu DNA polymerase activity"}
{"concept_id": "C1152384", "aliases": [], "types": ["T045"], "canonical_name": "nu DNA polymerase activity"}
{"concept_id": "C1152385", "aliases": [], "types": ["T045"], "canonical_name": "sigma DNA polymerase activity"}
{"concept_id": "C1152386", "aliases": [], "types": ["T045"], "canonical_name": "theta DNA polymerase activity"}
{"concept_id": "C1152387", "aliases": [], "types": ["T045"], "canonical_name": "zeta DNA polymerase activity"}
{"concept_id": "C1152388", "aliases": ["DNA-dependent RNA polymerase activity", "RNA nucleotidyltransferase (DNA-directed) activity", "DNA-dependent ribonucleate nucleotidyltransferase activity", "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity", "DNA-directed RNA polymerase activity", "DNA-dependent RNA nucleotidyltransferase activity", "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity"], "types": ["T045"], "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [EC:2.7.7.6, GOC:pf]", "canonical_name": "DNA-directed 5'-3' RNA polymerase activity"}
{"concept_id": "C1152389", "aliases": [], "types": ["T045"], "definition": "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436]", "canonical_name": "DNA primase activity"}
{"concept_id": "C1152390", "aliases": ["DNA-directed RNA polymerase I activity"], "types": ["T045"], "canonical_name": "DNA-directed RNA polymerase I activity", "definition": "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). [EC:2.7.7.6]"}
{"concept_id": "C1152391", "aliases": [], "types": ["T045"], "canonical_name": "DNA-directed RNA polymerase II activity", "definition": "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). [EC:2.7.7.6]"}
{"concept_id": "C1152392", "aliases": ["DNA-directed RNA polymerase III activity"], "types": ["T045"], "canonical_name": "DNA-directed RNA polymerase III activity", "definition": "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). [EC:2.7.7.6]"}
{"concept_id": "C1152393", "aliases": ["CTP:ethanolamine-phosphate cytidylyltransferase activity", "ethanolamine-phosphate cytidylyltransferase activity", "ET", "CTP:phosphoethanolamine cytidylyltransferase activity", "CTP-phosphoethanolamine cytidylyltransferase activity", "phosphoethanolamine cytidylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine. [EC:2.7.7.14]", "canonical_name": "ethanolamine phosphate cytidylyltransferase activity"}
{"concept_id": "C1152394", "aliases": ["riboflavin adenine dinucleotide pyrophosphorylase activity", "FAD synthetase activity", "riboflavine adenine dinucleotide adenylyltransferase activity", "adenosine triphosphate-riboflavin mononucleotide transadenylase activity", "FAD pyrophosphorylase activity", "ATP:FMN adenylyltransferase activity", "flavin adenine dinucleotide synthetase activity", "FAD diphosphorylase activity", "FMN adenylyltransferase activity", "riboflavin mononucleotide adenylyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + FMN = diphosphate + FAD. [EC:2.7.7.2, RHEA:17237]", "canonical_name": "adenosine triphosphate-riboflavine mononucleotide transadenylase activity"}
{"concept_id": "C1152395", "aliases": ["gentamycin 2''-nucleotidyltransferase activity"], "types": ["T044"], "canonical_name": "gentamicin 2''-nucleotidyltransferase activity"}
{"concept_id": "C1152396", "aliases": ["ADP-glucose pyrophosphorylase activity", "adenosine diphosphate glucose pyrophosphorylase activity", "ADP-glucose diphosphorylase activity", "glucose 1-phosphate adenylyltransferase activity", "ADGase activity", "ADP-glucose synthase activity", "ATP:alpha-glucose-1-phosphate adenylyl transferase activity", "ADPG pyrophosphorylase activity", "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity", "glucose-1-phosphate adenylyltransferase activity", "ADP glucose pyrophosphorylase activity", "ADP-glucose synthetase activity", "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate. [EC:2.7.7.27, RHEA:12120]", "canonical_name": "adenosine diphosphoglucose pyrophosphorylase activity"}
{"concept_id": "C1152397", "aliases": ["dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity", "TDP-glucose pyrophosphorylase activity", "thymidine diphosphate glucose pyrophosphorylase activity", "glucose-1-phosphate thymidylyltransferase activity", "dTDP-glucose pyrophosphorylase activity", "dTDP-glucose synthase activity", "glucose 1-phosphate thymidylyltransferase activity", "dTDP-glucose diphosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose. [EC:2.7.7.24, RHEA:15225]", "canonical_name": "thymidine diphosphoglucose pyrophosphorylase activity"}
{"concept_id": "C1152398", "aliases": ["ATP:glutamine synthetase adenylyltransferase activity", "glutamine-synthetase adenylyltransferase activity", "glutamate-ammonia-ligase adenylyltransferase activity", "[glutamate-ammonia-ligase] adenylyltransferase activity", "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity", "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. [EC:2.7.7.42]", "canonical_name": "adenosine triphosphate:glutamine synthetase adenylyltransferase activity"}
{"concept_id": "C1152399", "aliases": [], "types": ["T044"], "canonical_name": "mannose-phosphate guanylyltransferase activity", "definition": "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule. [GOC:mah]"}
{"concept_id": "C1152400", "aliases": ["GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity", "guanosine diphosphomannose pyrophosphorylase activity", "GTP:mannose-1-phosphate guanylyltransferase activity", "mannose-1-phosphate guanylyltransferase activity", "GTP-mannose-1-phosphate guanylyltransferase activity", "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity", "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. [EC:2.7.7.13, RHEA:15229]", "canonical_name": "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)"}
{"concept_id": "C1152401", "aliases": ["mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity", "GDP-mannose 1-phosphate guanylyltransferase activity", "mannose-1-phosphate guanylyltransferase (GDP) activity", "mannose 1-phosphate guanylyltransferase activity", "GDP:mannose-1-phosphate guanylyltransferase activity", "guanosine diphosphomannose phosphorylase activity", "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity", "GDP-mannose phosphorylase activity", "GDP:D-mannose-1-phosphate guanylyltransferase activity", "GDP mannose phosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate. [EC:2.7.7.22, RHEA:12905]", "canonical_name": "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity"}
{"concept_id": "C1152402", "aliases": ["adenosine triphosphate-nicotinamide mononucleotide transadenylase activity", "NAD+ diphosphorylase activity", "NAD(+) pyrophosphorylase activity", "ATP:NMN adenylyltransferase activity", "NAD+ pyrophosphorylase activity", "nicotinamide-nucleotide adenylyltransferase activity", "ATP:nicotinamide-nucleotide adenylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. [EC:2.7.7.1]", "canonical_name": "NAD(+) diphosphorylase activity"}
{"concept_id": "C1152403", "aliases": ["deamido-NAD(+) pyrophosphorylase activity", "deamido-NAD(+) diphosphorylase activity", "nicotinate mononucleotide adenylyltransferase activity", "deamido-NAD+ pyrophosphorylase activity", "ATP:nicotinate-nucleotide adenylyltransferase activity", "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity", "ATP:nicotinate-ribonucleotide adenylyltransferase activity", "nicotinate-nucleotide adenylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. [EC:2.7.7.18]", "canonical_name": "NaMN-ATase activity"}
{"concept_id": "C1152404", "aliases": ["PPAT activity", "3'-dephospho-CoA pyrophosphorylase activity", "ATP:pantetheine-phosphate adenylyltransferase activity", "ATP:pantetheine-4'-phosphate adenylyltransferase activity", "dephospho-coenzyme A pyrophosphorylase activity", "pantetheine phosphate adenylyltransferase activity", "dephospho-CoA diphosphorylase activity", "dephospho-CoA pyrophosphorylase activity", "phosphopantetheine adenylyltransferase activity"], "types": ["T044"], "canonical_name": "pantetheine-phosphate adenylyltransferase activity", "definition": "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate. [EC:2.7.7.3, RHEA:19801]"}
{"concept_id": "C1152405", "aliases": ["CTP-diacylglycerol synthetase activity", "cytidine diphosphoglyceride pyrophosphorylase activity", "CTP:phosphatidate cytidylyltransferase activity", "CDP-DG", "CDP-diglyceride synthetase activity", "phosphatidate cytidyltransferase activity", "phosphatidic acid cytidylyltransferase activity", "CDP-diacylglycerol synthase activity", "CDP-diglyceride pyrophosphorylase activity", "phosphatidate cytidylyltransferase activity", "DAG synthetase activity", "CDP-diacylglyceride synthetase activity", "CDP diglyceride pyrophosphorylase activity", "CDP-diglyceride diphosphorylase activity", "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. [EC:2.7.7.41]", "canonical_name": "CDP-diglyceride synthase activity"}
{"concept_id": "C1152406", "aliases": ["ATP:polynucleotidylexotransferase activity", "polynucleotide adenylyltransferase activity", "ATP:polynucleotide adenylyltransferase activity", "RNA adenylating enzyme activity", "poly(A) synthetase activity", "terminal riboadenylate transferase activity", "adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "poly(A) hydrolase activity", "NTP polymerase activity", "polyadenylate nucleotidyltransferase activity", "polyadenylic polymerase activity", "AMP polynucleotidylexotransferase activity", "polyadenylic acid polymerase activity", "polyadenylate synthetase activity", "poly(A) polymerase activity", "poly-A polymerase activity", "ATP-polynucleotide adenylyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. [EC:2.7.7.19]", "canonical_name": "polyadenylate polymerase activity"}
{"concept_id": "C1152407", "aliases": ["nucleoside diphosphate:polynucleotidyl transferase activity", "polyribonucleotide phosphorylase activity", "polyribonucleotide nucleotidyltransferase activity", "polyribonucleotide:phosphate nucleotidyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate. [EC:2.7.7.8]", "canonical_name": "polynucleotide phosphorylase activity"}
{"concept_id": "C1152408", "aliases": [], "types": ["T045"], "definition": "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule. [GOC:mah]", "canonical_name": "RNA guanylyltransferase activity"}
{"concept_id": "C1152409", "aliases": ["GTP--RNA guanylyltransferase activity", "mRNA guanylyltransferase activity", "GTP:mRNA guanylyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. [EC:2.7.7.50]", "canonical_name": "messenger RNA guanylyltransferase activity"}
{"concept_id": "C1152410", "aliases": [], "types": ["T045"], "definition": "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. [PMID:1660461]", "canonical_name": "tRNA guanylyltransferase activity"}
{"concept_id": "C1152411", "aliases": ["RNA-directed DNA polymerase activity", "reverse transcriptase activity", "DNA nucleotidyltransferase (RNA-directed) activity", "RNA revertase activity", "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity", "RNA-instructed DNA polymerase activity", "RNA-dependent DNA polymerase activity", "RT"], "types": ["T045"], "definition": "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. [EC:2.7.7.49]", "canonical_name": "RNA-dependent deoxyribonucleate nucleotidyltransferase activity"}
{"concept_id": "C1152412", "aliases": ["RNA-dependent RNA replicase activity", "ribonucleic acid replicase activity", "RNA-directed RNA polymerase activity", "RNA-directed 5'-3' RNA polymerase activity", "RDRP", "ribonucleic replicase activity", "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "ribonucleic acid-dependent ribonucleic acid polymerase activity", "RNA replicase activity", "3D polymerase activity", "Q-beta replicase activity", "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "RNA-dependent ribonucleate nucleotidyltransferase activity", "RNA nucleotidyltransferase (RNA-directed) activity"], "types": ["T045"], "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. [EC:2.7.7.48, GOC:mah, GOC:pf]", "canonical_name": "RNA-dependent RNA polymerase activity"}
{"concept_id": "C1152413", "aliases": ["ATP:streptomycin 3''-adenylyltransferase activity"], "types": ["T044"], "canonical_name": "streptomycin 3''-adenylyltransferase activity"}
{"concept_id": "C1152414", "aliases": ["sulfate adenylyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate. [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN]", "canonical_name": "sulphate adenylyltransferase activity"}
{"concept_id": "C1152415", "aliases": ["sulfate adenylyltransferase (ADP) activity", "sulfate (adenosine diphosphate) adenylyltransferase activity", "sulphate adenylyltransferase (ADP) activity", "ADP:sulfate adenylyltransferase activity", "adenosine diphosphate sulfurylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate. [EC:2.7.7.5, RHEA:16529]", "canonical_name": "ADP-sulfurylase activity"}
{"concept_id": "C1152416", "aliases": ["adenosine-5'-triphosphate sulfurylase activity", "adenosinetriphosphate sulfurylase activity", "adenylylsulfate pyrophosphorylase activity", "ATP:sulfate adenylyltransferase activity", "sulfate adenylate transferase activity", "ATP-sulfurylase activity", "ATP sulfurylase activity", "sulphate adenylyltransferase (ATP) activity"], "types": ["T044"], "canonical_name": "sulfate adenylyltransferase (ATP) activity", "definition": "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. [EC:2.7.7.4]"}
{"concept_id": "C1152417", "aliases": ["tRNA adenylyltransferase activity", "transfer ribonucleate adenyltransferase activity", "ATP:tRNA adenylyltransferase activity", "transfer RNA adenylyltransferase"], "types": ["T045"], "definition": "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1). [RHEA:14433]", "canonical_name": "transfer-RNA nucleotidyltransferase"}
{"concept_id": "C1152418", "aliases": [], "types": ["T045"], "definition": "Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1). [EC:2.7.7.21]", "canonical_name": "tRNA cytidylyltransferase activity"}
{"concept_id": "C1152419", "aliases": ["ribonuclease PH activity", "tRNA:phosphate nucleotidyltransferase activity", "tRNA nucleotidyltransferase activity", "RNase PH activity"], "types": ["T045"], "definition": "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. [EC:2.7.7.56]", "canonical_name": "tRNA-nucleotidyltransferase activity"}
{"concept_id": "C1152420", "aliases": ["UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity", "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity", "UDP-glucose-hexose-1-phosphate uridylyltransferase activity", "UDPglucose-hexose-1-phosphate uridylyltransferase activity", "hexose-1-phosphate uridylyltransferase activity", "hexose 1-phosphate uridyltransferase activity"], "types": ["T044"], "canonical_name": "UDP-glucose:hexose-1-phosphate uridylyltransferase activity", "definition": "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. [EC:2.7.7.12, RHEA:13989]"}
{"concept_id": "C1152421", "aliases": ["uridine diphosphoacetylglucosamine pyrophosphorylase activity", "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity", "N-acetylglucosamine-1-phosphate uridyltransferase activity", "GlmU uridylyltransferase activity", "uridine diphosphoacetylglucosamine phosphorylase activity", "UDP-acetylglucosamine pyrophosphorylase activity", "UDP-N-acetylglucosamine pyrophosphorylase activity", "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity", "UDP-GlcNAc pyrophosphorylase activity", "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. [EC:2.7.7.23, RHEA:13509]", "canonical_name": "UDP-N-acetylglucosamine diphosphorylase activity"}
{"concept_id": "C1152423", "aliases": ["UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity", "glucose-1-phosphate uridylyltransferase activity", "uridine diphosphoglucose pyrophosphorylase activity", "uridine-diphosphate glucose pyrophosphorylase activity", "uridine diphosphate-D-glucose pyrophosphorylase activity", "UDP-glucose pyrophosphorylase activity", "uridine 5'-diphosphoglucose pyrophosphorylase activity", "UDPG pyrophosphorylase activity", "UDPG phosphorylase activity", "UDP glucose pyrophosphorylase activity", "UTP:glucose-1-phosphate uridylyltransferase activity", "UTP-glucose-1-phosphate uridylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. [EC:2.7.7.9, RHEA:19889]", "canonical_name": "UDP-glucose diphosphorylase activity"}
{"concept_id": "C1152424", "aliases": ["galactose-1-phosphate uridylyltransferase activity", "alpha-D-galactose 1-phosphate uridylyltransferase activity", "galactose 1-phosphate uridylyltransferase activity", "uridine diphosphogalactose pyrophosphorylase activity", "UDPgalactose pyrophosphorylase activity", "UTP-hexose-1-phosphate uridylyltransferase activity", "UTP:galactose-1-phosphate uridylyltransferase activity", "uridine diphosphate galactose pyrophosphorylase activity", "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity", "galactose 1-phosphate uridyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose. [EC:2.7.7.10, RHEA:14209]", "canonical_name": "UTP:hexose-1-phosphate uridylyltransferase activity"}
{"concept_id": "C1152425", "aliases": ["protein-PII uridylyltransferase activity", "UTP:protein-PII uridylyltransferase activity", "PII uridylyl-transferase activity", "[protein-PII] uridylyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). [EC:2.7.7.59]", "canonical_name": "UTP:[protein-PII] uridylyltransferase activity"}
{"concept_id": "C1152426", "aliases": [], "types": ["T044"], "canonical_name": "phosphotransferase activity, alcohol group as acceptor", "definition": "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). [GOC:jl]"}
{"concept_id": "C1152427", "aliases": ["5-methylthioribose kinase activity", "5-methylthioribose kinase (phosphorylating)", "S-methyl-5-thioribose kinase activity", "ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity", "methylthioribose kinase activity", "MTR kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H(+). [EC:2.7.1.100, RHEA:22312]", "canonical_name": "ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity"}
{"concept_id": "C1152428", "aliases": ["ATP:D-gluconate 6-phosphotransferase activity", "gluconokinase (phosphorylating)", "gluconate kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+). [EC:2.7.1.12, RHEA:19433]", "canonical_name": "gluconokinase activity"}
{"concept_id": "C1152429", "aliases": ["mannokinase (phosphorylating)", "ATP:D-mannose 6-phosphotransferase activity", "D-fructose (D-mannose) kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate. [EC:2.7.1.7]", "canonical_name": "mannokinase activity"}
{"concept_id": "C1152430", "aliases": [], "types": ["T044"], "canonical_name": "phenol kinase activity", "definition": "Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate. [UM-BBD_reactionID:r0155]"}
{"concept_id": "C1152431", "aliases": ["protein-Npi-phosphohistidine-sugar phosphotransferase activity", "enzyme II of the phosphotransferase system", "PTS transporter", "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity", "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity", "protein-Np-phosphohistidine-sugar phosphotransferase activity", "phosphohistidinoprotein-hexose phosphoribosyltransferase activity", "phosphotransferase, phosphohistidinoprotein-hexose activity", "phosphoprotein factor-hexose phosophotransferase activity", "PTS permease activity", "phosphotransfer-driven group translocator", "phosphohistidinoprotein-hexose phosphotransferase activity", "protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]", "canonical_name": "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity"}
{"concept_id": "C1152434", "aliases": ["cellobiose permease activity"], "types": ["T044"], "canonical_name": "cellobiose transmembrane transporter activity", "definition": "Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1152435", "aliases": ["fructose porter activity", "fructose transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "fructose permease activity"}
{"concept_id": "C1152437", "aliases": ["galactitol permease activity"], "types": ["T044"], "canonical_name": "galactitol transmembrane transporter activity", "definition": "Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1152438", "aliases": ["galactosamine porter activity"], "types": ["T044"], "canonical_name": "galactosamine transmembrane transporter activity", "definition": "Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1152439", "aliases": ["glucitol transporter activity", "sorbitol transmembrane transporter activity", "sorbitol permease activity"], "types": ["T044"], "definition": "Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose. [GOC:ai, ISBN:0198506732]", "canonical_name": "glucitol permease activity"}
{"concept_id": "C1152440", "aliases": ["glucose transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "glucose permease activity"}
{"concept_id": "C1152441", "aliases": ["lactose permease activity"], "types": ["T044"], "canonical_name": "lactose transmembrane transporter activity", "definition": "Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1152442", "aliases": ["maltose porter activity"], "types": ["T044"], "canonical_name": "maltose transmembrane transporter activity", "definition": "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1152443", "aliases": ["mannitol permease activity"], "types": ["T044"], "canonical_name": "mannitol transmembrane transporter activity", "definition": "Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1152444", "aliases": ["mannose transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "mannose permease activity"}
{"concept_id": "C1152445", "aliases": ["N-acetylgalactosamine permease activity"], "types": ["T044"], "canonical_name": "N-acetylgalactosamine transmembrane transporter activity", "definition": "Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1152446", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylglucosamine permease activity"}
{"concept_id": "C1152447", "aliases": ["sorbose porter activity"], "types": ["T044"], "canonical_name": "sorbose transmembrane transporter activity", "definition": "Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1152449", "aliases": ["trehalose permease activity"], "types": ["T044"], "canonical_name": "trehalose transmembrane transporter activity", "definition": "Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1152451", "aliases": [], "types": ["T044"], "canonical_name": "phosphotransferase activity, carboxyl group as acceptor", "definition": "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). [GOC:jl]"}
{"concept_id": "C1152452", "aliases": [], "types": ["T044"], "canonical_name": "phosphotransferase activity, for other substituted phosphate groups", "definition": "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). [GOC:jl]"}
{"concept_id": "C1152453", "aliases": ["carboxyvinyl-carboxyphosphonate phosphorylmutase activity", "carboxyphosphonoenolpyruvate phosphonomutase activity", "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2. [EC:2.7.8.23]", "canonical_name": "CPEP phosphonomutase activity"}
{"concept_id": "C1152454", "aliases": [], "types": ["T044"], "canonical_name": "CDP-alcohol phosphatidyltransferase activity", "definition": "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. [GOC:ai]"}
{"concept_id": "C1152455", "aliases": ["phosphatidylglycerophosphate synthase activity", "glycerol 3-phosphate phosphatidyltransferase activity", "PGP synthase activity", "sn-glycerol-3-phosphate phosphatidyltransferase activity", "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity", "phosphatidylglycerolphosphate synthase activity", "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity", "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity", "phosphatidylglycerol phosphate synthetase activity", "glycerol phosphate phosphatidyltransferase activity", "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity", "phosphatidylglycerophosphate synthetase activity", "glycerophosphate phosphatidyltransferase activity", "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity", "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity", "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity", "phosphatidylglycerol phosphate synthase activity"], "types": ["T044"], "canonical_name": "CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+). [EC:2.7.8.5, RHEA:12593]"}
{"concept_id": "C1152456", "aliases": ["CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity", "cytidine diphosphoglyceride-inositol transferase activity", "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity", "CDP diglyceride-inositol phosphatidyltransferase activity", "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity", "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity", "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity", "CDP-diacylglycerol--inositol phosphatidyltransferase activity", "phosphatidylinositol synthase activity", "CDP-diglyceride:inositol transferase activity", "CDP-diglyceride-inositol transferase activity", "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity", "CDP-DG:inositol transferase activity"], "types": ["T044"], "canonical_name": "CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity", "definition": "Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+). [EC:2.7.8.11, RHEA:11580]"}
{"concept_id": "C1152457", "aliases": ["CDP-diglyceride:serine phosphatidyltransferase activity", "phosphatidylserine synthase activity", "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "CDP-diglycerine-serine O-phosphatidyltransferase activity", "CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "CDPdiglyceride-serine O-phosphatidyltransferase activity", "phosphatidylserine synthetase activity", "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "CDP-diglyceride-L-serine phosphatidyltransferase activity", "PS synthase activity", "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine. [EC:2.7.8.8]", "canonical_name": "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity"}
{"concept_id": "C1152458", "aliases": ["1-alkyl-2-acetylglycerol cholinephosphotransferase activity", "CPT", "cytidine diphosphorylcholine diglyceride transferase activity", "sn-1,2-diacylglycerol cholinephosphotransferase activity", "phosphocholine diacylglyceroltransferase activity", "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity", "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity", "alkylacylglycerol cholinephosphotransferase activity", "phosphorylcholine--glyceride transferase activity", "diacylglycerol cholinephosphotransferase activity", "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity", "alkylacylglycerol choline phosphotransferase activity", "cytidine diphosphocholine glyceride transferase activity", "CDP-choline diglyceride phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine. [EC:2.7.8.2, RHEA:32939]", "canonical_name": "diacylglycerol choline phosphotransferase activity"}
{"concept_id": "C1152459", "aliases": ["CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity", "CDPethanolamine diglyceride phosphotransferase activity", "ethanolaminephosphotransferase activity", "diacylglycerol ethanolaminephosphotransferase activity", "phosphorylethanolamine-glyceride transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine. [EC:2.7.8.1, RHEA:32943]", "canonical_name": "EPT"}
{"concept_id": "C1152460", "aliases": [], "types": ["T044"], "canonical_name": "GDP-mannose:serine-protein mannose-1-phosphotransferase activity", "definition": "Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein. [GOC:mah, PMID:10037765]"}
{"concept_id": "C1152461", "aliases": ["CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity", "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity", "acyl carrier protein holoprotein (holo-ACP) synthetase activity", "holo-ACP synthase activity", "holo-acyl-carrier-protein synthase activity", "holo-[acyl-carrier-protein] synthase activity", "PPTase activity", "alpha-aminoadipate reductase phosphopantetheinyl transferase activity", "4'-phosphopantetheinyltransferase activity", "P-pant transferase activity", "ACPS activity", "AcpS", "4'-phosphopantetheinyl transferase activity", "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity", "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity", "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709]", "canonical_name": "phosphopantetheinyltransferase activity"}
{"concept_id": "C1152462", "aliases": ["oligosaccharide glycerophosphotransferase activity", "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity", "phosphoglycerol transferase I"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose. [EC:2.7.8.20]", "canonical_name": "phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity"}
{"concept_id": "C1152463", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidyltransferase activity", "definition": "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group. [GOC:mb]"}
{"concept_id": "C1152464", "aliases": ["cardiolipin synthase activity", "cardiolipin synthase", "diphosphatidylglycerol synthase activity", "cardiolipin synthetase"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. [GOC:jl, RHEA:31451]", "canonical_name": "cardiolipin synthetase activity"}
{"concept_id": "C1152465", "aliases": ["UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity", "phosphoacetylmuramoylpentapeptide translocase activity", "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity", "phospho-N-acetylmuramoyl-pentapeptide-transferase activity", "phospho-N-acetylmuramoyl pentapeptide translocase activity", "phospho-MurNAc-pentapeptide transferase activity", "UDP-MurNAc-pentapeptide phosphotransferase activity", "phosphoacetylmuramoylpentapeptidetransferase activity", "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity", "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity", "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. [EC:2.7.8.13]", "canonical_name": "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity"}
{"concept_id": "C1152467", "aliases": ["UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity", "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity", "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity", "N-acetylglucosaminylphosphotransferase activity", "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity", "N-acetylglucosaminyl phosphotransferase activity", "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity", "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity"], "types": ["T044"], "canonical_name": "UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. [EC:2.7.8.17]"}
{"concept_id": "C1152468", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity", "definition": "Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein. [GOC:mah, PMID:9353330]"}
{"concept_id": "C1152469", "aliases": [], "types": ["T044"], "canonical_name": "phosphotransferase activity, nitrogenous group as acceptor", "definition": "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). [GOC:jl]"}
{"concept_id": "C1152470", "aliases": [], "types": ["T044"], "canonical_name": "phosphotransferase activity, paired acceptors", "definition": "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors. [GOC:jl]"}
{"concept_id": "C1152471", "aliases": [], "types": ["T044"], "canonical_name": "phosphotransferase activity, phosphate group as acceptor", "definition": "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). [GOC:jl]"}
{"concept_id": "C1152473", "aliases": [], "types": ["T044"], "canonical_name": "transferase activity, transferring sulphur-containing groups", "definition": "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1152474", "aliases": [], "types": ["T044"], "canonical_name": "CoA-transferase activity", "definition": "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). [GOC:jl]"}
{"concept_id": "C1152475", "aliases": ["succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity", "3-ketoacid CoA-transferase activity", "3-oxo-CoA transferase activity", "3-oxoacid CoA dehydrogenase activity", "3-oxoacid coenzyme A-transferase activity", "acetoacetyl coenzyme A-succinic thiophorase activity", "3-oxoacid CoA-transferase activity", "succinyl-CoA:3-ketoacid-CoA transferase activity", "succinyl-CoA:3-oxo-acid CoA-transferase activity", "succinyl-CoA transferase activity", "acetoacetate succinyl-CoA transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA. [EC:2.8.3.5]", "canonical_name": "3-ketoacid coenzyme A transferase activity"}
{"concept_id": "C1152476", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate. [GOC:jl]", "canonical_name": "4-hydroxybutyrate CoA-transferase activity"}
{"concept_id": "C1152477", "aliases": ["butyryl coenzyme A transferase activity", "acyl-CoA:acetate CoA-transferase activity", "butyryl CoA:acetate CoA transferase activity", "acetate coenzyme A-transferase activity", "acetyl-CoA:acetoacetate CoA transferase activity", "acetate CoA-transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. [EC:2.8.3.8]", "canonical_name": "succinyl-CoA:acetate CoA transferase activity"}
{"concept_id": "C1152478", "aliases": ["acetyl-CoA:citrate CoA-transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA. [EC:2.8.3.10]", "canonical_name": "citrate CoA-transferase activity"}
{"concept_id": "C1152479", "aliases": ["acetyl-CoA:(E)-glutaconate CoA-transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA. [EC:2.8.3.12]", "canonical_name": "glutaconate CoA-transferase activity"}
{"concept_id": "C1152480", "aliases": ["propionyl CoA:acetate CoA transferase activity", "propionate coenzyme A-transferase activity", "propionyl-CoA transferase activity", "acetyl-CoA:propanoate CoA-transferase activity", "propionate-CoA:lactoyl-CoA transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA. [EC:2.8.3.1]", "canonical_name": "propionate CoA-transferase activity"}
{"concept_id": "C1152482", "aliases": ["transferase activity, transferring selenium-containing groups"], "types": ["T044"], "canonical_name": "selenotransferase activity", "definition": "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1152484", "aliases": ["L-seryl-tRNASec selenium transferase activity", "selenocysteinyl-tRNA(Ser) synthase activity", "L-selenocysteinyl-tRNASec synthase activity", "L-selenocysteinyl-tRNA(Sec) synthase activity", "cysteinyl-tRNA(Sel)-selenium transferase activity", "L-seryl-tRNA(Ser) selenium transferase activity", "L-selenocysteinyl-tRNA(Sel) synthase activity", "cysteinyl-tRNASel-selenium transferase activity", "cysteinyl-tRNASec-selenium transferase activity", "selenocysteine synthase activity", "selenophosphate:L-seryl-tRNASec selenium transferase activity", "L-selenocysteinyl-tRNASel synthase activity", "cysteinyl-tRNA(Sec)-selenium transferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate. [RHEA:22728]", "canonical_name": "cysteinyl-tRNA(Ser) selenium transferase activity"}
{"concept_id": "C1152485", "aliases": ["sulphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. [GOC:curators]", "canonical_name": "sulfotransferase activity"}
{"concept_id": "C1152486", "aliases": ["5alpha-androstenol sulfotransferase activity", "dehydroepiandrosterone sulfotransferase activity", "HST", "alcohol sulfotransferase activity", "delta5-3beta-hydroxysteroid sulfokinase activity", "hydroxysteroid sulfotransferase activity", "alcohol/hydroxysteroid sulfotransferase activity", "estrogen sulfokinase activity", "3-hydroxysteroid sulfotransferase activity", "sterol sulfokinase activity", "3beta-hydroxysteroid sulfotransferase activity", "3beta-hydroxy steroid sulfotransferase activity", "steroid sulfokinase activity", "alcohol sulphotransferase activity", "sterol sulfotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. [EC:2.8.2.2]", "canonical_name": "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity"}
{"concept_id": "C1152487", "aliases": ["3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity", "dopamine sulfotransferase activity", "ritodrine sulfotransferase activity", "p-nitrophenol sulfotransferase activity", "1-naphthol phenol sulfotransferase activity", "PST", "phenol sulfokinase activity", "4-nitrocatechol sulfokinase activity", "2-naphtholsulfotransferase activity", "phenol sulfotransferase activity", "aryl sulfotransferase activity", "aryl sulphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. [EC:2.8.2.1]", "canonical_name": "arylsulfotransferase"}
{"concept_id": "C1152488", "aliases": ["terminal 6-sulfotransferase activity", "chondroitin 6-sulphotransferase activity", "chondroitin 6-O-sulfotransferase activity", "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity", "chondroitin 6-sulfotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. [EC:2.8.2.17]", "canonical_name": "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity"}
{"concept_id": "C1152489", "aliases": ["heparin N-deacetylase/N-sulphotransferase activity"], "types": ["T044"], "canonical_name": "heparin N-deacetylase/N-sulfotransferase activity"}
{"concept_id": "C1152490", "aliases": ["estrogen sulphotransferase activity", "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity", "estrone sulphotransferase activity", "estrone sulfotransferase activity", "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity", "oestrogen sulphotransferase activity", "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. [EC:2.8.2.4]", "canonical_name": "estrogen sulfotransferase"}
{"concept_id": "C1152491", "aliases": ["heparan sulphate 6-O-sulphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate. [PMID:8631808]", "canonical_name": "heparan sulfate 6-O-sulfotransferase activity"}
{"concept_id": "C1152493", "aliases": ["heparin-glucosamine 3-O-sulphotransferase activity"], "types": ["T044"], "canonical_name": "heparin-glucosamine 3-O-sulfotransferase activity"}
{"concept_id": "C1152494", "aliases": ["heparan-sulfate 2-O-sulphotransferase activity", "heparin-sulphate 2-sulphotransferase activity"], "types": ["T044"], "canonical_name": "heparan sulfate 2-O-sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate. [PMID:9153262]"}
{"concept_id": "C1152496", "aliases": ["HNK-1 sulphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R). [PMID:9478973]", "canonical_name": "HNK-1 sulfotransferase activity"}
{"concept_id": "C1152497", "aliases": ["keratan sulfate Gal-6-sulfotransferase activity", "keratan sulfate sulfotransferase activity", "3'-phosphoadenylyl keratan sulfotransferase activity", "3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity", "keratan sulfotransferase activity", "keratan sulphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate. [EC:2.8.2.21]", "canonical_name": "3'-phosphoadenylylsulfate:keratan sulfotransferase activity"}
{"concept_id": "C1152498", "aliases": ["N-acetylgalactosamine 4-O-sulfotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate. [EC:2.8.2.-, GOC:ai]", "canonical_name": "N-acetylgalactosamine 4-O-sulphotransferase activity"}
{"concept_id": "C1152499", "aliases": ["N-acetylglucosamine 6-O-sulphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. [GOC:ai, GOC:hjd]", "canonical_name": "N-acetylglucosamine 6-O-sulfotransferase activity"}
{"concept_id": "C1152500", "aliases": ["phenanthrol sulphotransferase activity"], "types": ["T044"], "canonical_name": "phenanthrol sulfotransferase activity", "definition": "Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate. [EC:2.8.2.-]"}
{"concept_id": "C1152501", "aliases": ["1-phenanthrol sulphotransferase activity"], "types": ["T044"], "canonical_name": "1-phenanthrol sulfotransferase activity", "definition": "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate. [UM-BBD_reactionID:r0565]"}
{"concept_id": "C1152502", "aliases": ["2-phenanthrol sulphotransferase activity"], "types": ["T044"], "canonical_name": "2-phenanthrol sulfotransferase activity", "definition": "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate. [UM-BBD_reactionID:r0563]"}
{"concept_id": "C1152503", "aliases": ["3-phenanthrol sulphotransferase activity"], "types": ["T044"], "canonical_name": "3-phenanthrol sulfotransferase activity", "definition": "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate. [UM-BBD_reactionID:r0561]"}
{"concept_id": "C1152504", "aliases": ["4-phenanthrol sulphotransferase activity"], "types": ["T044"], "canonical_name": "4-phenanthrol sulfotransferase activity", "definition": "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate. [UM-BBD_reactionID:r0562]"}
{"concept_id": "C1152505", "aliases": ["9-phenanthrol sulphotransferase activity"], "types": ["T044"], "canonical_name": "9-phenanthrol sulfotransferase activity", "definition": "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate. [UM-BBD_reactionID:r0564]"}
{"concept_id": "C1152506", "aliases": ["protein-tyrosine sulphotransferase activity", "tyrosylprotein sulfotransferase activity", "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate. [EC:2.8.2.20]", "canonical_name": "protein-tyrosine sulfotransferase activity"}
{"concept_id": "C1152507", "aliases": ["trans-3,4-dihydrodiolphenanthrene sulphotransferase activity"], "types": ["T044"], "canonical_name": "trans-3,4-dihydrodiolphenanthrene sulfotransferase activity", "definition": "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate. [UM-BBD_reactionID:r0558]"}
{"concept_id": "C1152508", "aliases": ["trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity"], "types": ["T044"], "canonical_name": "trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity", "definition": "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate. [UM-BBD_reactionID:r0559]"}
{"concept_id": "C1152509", "aliases": ["tyrosine-ester sulfotransferase activity", "tyrosine-ester sulphotransferase activity", "L-tyrosine methyl ester sulfotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H(+). [EC:2.8.2.9, RHEA:19977]", "canonical_name": "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity"}
{"concept_id": "C1152510", "aliases": ["sulfurtransferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). [GOC:ai, ISBN:0721662544]", "canonical_name": "sulphurtransferase activity"}
{"concept_id": "C1152511", "aliases": ["3-mercaptopyruvate sulfurtransferase activity", "beta-mercaptopyruvate sulfurtransferase activity", "3-mercaptopyruvate:cyanide sulfurtransferase activity", "3-mercaptopyruvate sulphurtransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. [EC:2.8.1.2]", "canonical_name": "mercaptopyruvate sulfurtransferase activity"}
{"concept_id": "C1152512", "aliases": ["dethiobiotin:sulfur sulfurtransferase activity", "biotin synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+). [EC:2.8.1.6, RHEA:22060]", "canonical_name": "biotin synthase activity"}
{"concept_id": "C1152513", "aliases": ["thiosulfate:cyanide sulfurtransferase activity", "thiosulfate cyanide transsulfurase activity", "thiosulfate thiotransferase activity", "thiosulfate sulfurtransferase activity", "rhodanase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate. [EC:2.8.1.1, RHEA:16881]", "canonical_name": "thiosulphate sulphurtransferase activity"}
{"concept_id": "C1152514", "aliases": [], "types": ["T045"], "definition": "OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide. [EC:2.8.1.4]", "canonical_name": "tRNA sulfurtransferase activity"}
{"concept_id": "C1152515", "aliases": [], "types": ["T044"], "canonical_name": "trichothecene 3-O-acetyltransferase activity", "definition": "Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis. [PMID:10583973]"}
{"concept_id": "C1152516", "aliases": ["2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity", "Tpt1p", "tRNA 2'-phosphotransferase activity", "2'-phospho-tRNA:NAD+ phosphotransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. [EC:2.7.1.160, PMID:9148937]", "canonical_name": "Tpt1"}
{"concept_id": "C1152517", "aliases": [], "types": ["T044"], "definition": "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. [GOC:bm, ISBN:0198506732]", "canonical_name": "transposase activity"}
{"concept_id": "C1152518", "aliases": [], "types": ["T044"], "canonical_name": "P-element encoded transposase activity"}
{"concept_id": "C1152519", "aliases": [], "types": ["T045"], "canonical_name": "tRNA dihydrouridine synthase activity", "definition": "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. [PMID:11983710]"}
{"concept_id": "C1152520", "aliases": [], "types": ["T044"], "canonical_name": "versicolorin B synthase activity", "definition": "Catalysis of the reaction: versiconal = versicolorin B + H2O. [MetaCyc:RXN-9494, PMID:8784203]"}
{"concept_id": "C1152521", "aliases": ["enzyme modulator", "catalytic regulator activity"], "types": ["T044"], "canonical_name": "enzyme regulator activity", "definition": "Binds to and modulates the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1152522", "aliases": [], "types": ["T044"], "canonical_name": "enzyme activator activity", "definition": "Binds to and increases the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1152523", "aliases": ["ATPase stimulator activity"], "types": ["T044"], "canonical_name": "ATPase activator activity", "definition": "Binds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp]"}
{"concept_id": "C1152524", "aliases": ["activator caspase activity"], "types": ["T044"], "canonical_name": "caspase activator activity"}
{"concept_id": "C1152525", "aliases": ["RanGAP", "GTPase activator activity", "Ran GAP activity", "Ran GTPase activator activity"], "types": ["T044"], "definition": "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]", "canonical_name": "GAP activity"}
{"concept_id": "C1152526", "aliases": ["ARF GAP activity"], "types": ["T044"], "canonical_name": "ARF GTPase activator activity"}
{"concept_id": "C1152527", "aliases": ["Rab GAP activity"], "types": ["T044"], "canonical_name": "Rab GTPase activator activity"}
{"concept_id": "C1152528", "aliases": ["Ral GAP activity"], "types": ["T044"], "canonical_name": "Ral GTPase activator activity"}
{"concept_id": "C1152530", "aliases": ["Rap GAP activity"], "types": ["T044"], "canonical_name": "Rap GTPase activator activity"}
{"concept_id": "C1152531", "aliases": ["Ras GAP activity"], "types": ["T044"], "canonical_name": "Ras GTPase activator activity"}
{"concept_id": "C1152532", "aliases": ["Rho GAP activity"], "types": ["T044"], "canonical_name": "Rho GTPase activator activity"}
{"concept_id": "C1152533", "aliases": ["Sar GAP activity"], "types": ["T044"], "canonical_name": "Sar GTPase activator activity"}
{"concept_id": "C1152534", "aliases": ["guanylate cyclase activator activity"], "types": ["T044"], "definition": "Binds to and increases the activity of guanylate cyclase. [GOC:mah]", "canonical_name": "guanylin"}
{"concept_id": "C1152535", "aliases": [], "types": ["T044"], "canonical_name": "calcium sensitive guanylate cyclase activator activity", "definition": "Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration. [GOC:mah]"}
{"concept_id": "C1152536", "aliases": [], "types": ["T044"], "canonical_name": "kinase activator activity", "definition": "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]"}
{"concept_id": "C1152537", "aliases": [], "types": ["T044"], "canonical_name": "protein kinase activator activity", "definition": "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]"}
{"concept_id": "C1152538", "aliases": ["eEF-2 kinase activator"], "types": ["T044"], "canonical_name": "eukaryotic elongation factor-2 kinase activator activity", "definition": "Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase. [GOC:jl, PMID:11904175]"}
{"concept_id": "C1152539", "aliases": [], "types": ["T044"], "canonical_name": "protein tyrosine kinase activator activity", "definition": "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1152540", "aliases": ["receptor signalling protein tyrosine kinase activator activity"], "types": ["T044"], "canonical_name": "receptor signaling protein tyrosine kinase activator activity", "definition": "Binds to and increases the activity of a receptor signaling protein tyrosine kinase. [GOC:mah]"}
{"concept_id": "C1152541", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor protein tyrosine kinase activator activity", "definition": "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase. [GOC:mah]"}
{"concept_id": "C1152542", "aliases": [], "types": ["T044"], "canonical_name": "phosphatase activator activity", "definition": "Binds to and increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. [GOC:ai]"}
{"concept_id": "C1152543", "aliases": [], "types": ["T044"], "canonical_name": "protein tyrosine phosphatase activator activity", "definition": "Binds to and increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1152544", "aliases": [], "types": ["T044"], "canonical_name": "phospholipase activator activity", "definition": "Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. [GOC:ai]"}
{"concept_id": "C1152545", "aliases": [], "types": ["T044"], "canonical_name": "phospholipase A2 activator activity", "definition": "Increases the activity of the enzyme phospholipase A2. [GOC:ai]"}
{"concept_id": "C1152547", "aliases": ["protease activator activity"], "types": ["T044"], "canonical_name": "peptidase activator activity", "definition": "Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. [GOC:ai]"}
{"concept_id": "C1152551", "aliases": [], "types": ["T044"], "canonical_name": "saposin"}
{"concept_id": "C1152552", "aliases": ["neutral sphingomyelinase activator"], "types": ["T044"], "canonical_name": "sphingomyelin phosphodiesterase activator activity", "definition": "Increases the activity of the enzyme sphingomyelin phosphodiesterase. [GOC:ai]"}
{"concept_id": "C1152553", "aliases": [], "types": ["T044"], "canonical_name": "superoxide-generating NADPH oxidase activator activity", "definition": "Increases the activity of the enzyme superoxide-generating NADPH oxidase. [GOC:ai]"}
{"concept_id": "C1152554", "aliases": [], "types": ["T044"], "canonical_name": "tryptophan hydroxylase activator activity", "definition": "Increases the activity of the enzyme tryptophase hydroxylase. [GOC:ai]"}
{"concept_id": "C1152555", "aliases": [], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of an enzyme. [GOC:ai, GOC:ebc]", "canonical_name": "enzyme inhibitor activity"}
{"concept_id": "C1152556", "aliases": [], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of alpha-amylase. [GOC:mah]", "canonical_name": "alpha-amylase inhibitor activity"}
{"concept_id": "C1152557", "aliases": ["adenosinetriphosphatase inhibitor"], "types": ["T044"], "canonical_name": "ATPase inhibitor activity", "definition": "Binds to and stops, prevents or reduces an ATP hydrolysis activity. [GOC:jl]"}
{"concept_id": "C1152558", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters. [ISBN:0198506732, PMID:11883709]", "canonical_name": "diazepam binding inhibitor activity"}
{"concept_id": "C1152559", "aliases": ["DNA gyrase inhibitor activity"], "types": ["T045"], "canonical_name": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. [GOC:mah]"}
{"concept_id": "C1152560", "aliases": [], "types": ["T044"], "canonical_name": "dUTP pyrophosphatase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase. [GOC:mah]"}
{"concept_id": "C1152561", "aliases": ["GIP"], "types": ["T044"], "definition": "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. [GOC:ai]", "canonical_name": "GTPase inhibitor activity"}
{"concept_id": "C1152562", "aliases": [], "types": ["T044"], "canonical_name": "guanylate cyclase inhibitor activity", "definition": "Stops, prevents or reduces the activity of guanylate cyclase. [GOC:mah]"}
{"concept_id": "C1152563", "aliases": [], "types": ["T044"], "canonical_name": "histone deacetylase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. [GOC:ai, PMID:10482575]"}
{"concept_id": "C1152565", "aliases": [], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]", "canonical_name": "protein kinase inhibitor activity"}
{"concept_id": "C1152566", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent protein kinase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase. [GOC:mah]"}
{"concept_id": "C1152567", "aliases": [], "types": ["T044"], "canonical_name": "cAMP-dependent protein kinase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase. [GOC:mah]"}
{"concept_id": "C1152568", "aliases": ["CDK inhibitor", "cyclin-dependent kinase inhibitor", "cyclin-dependent protein serine/threonine kinase inhibitor activity", "cyclin dependent protein kinase inhibitor activity", "cyclin dependent kinase inhibitor"], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:mah, GOC:pr]", "canonical_name": "cyclin-dependent protein kinase inhibitor activity"}
{"concept_id": "C1152570", "aliases": ["PKC inhibitor activity", "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity", "diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity"], "types": ["T044"], "canonical_name": "protein kinase C inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. [GOC:ai]"}
{"concept_id": "C1152571", "aliases": [], "types": ["T044"], "canonical_name": "protein serine/threonine kinase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase. [GOC:mah]"}
{"concept_id": "C1152572", "aliases": [], "types": ["T044"], "canonical_name": "protein tyrosine kinase inhibitor activity", "definition": "Stops, prevents or reduces the activity of a protein tyrosine kinase. [GOC:mah]"}
{"concept_id": "C1152573", "aliases": ["receptor signalling protein tyrosine kinase inhibitor activity"], "types": ["T044"], "canonical_name": "receptor signaling protein tyrosine kinase inhibitor activity", "definition": "Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase. [GOC:mah]"}
{"concept_id": "C1152574", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor protein tyrosine kinase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase. [GOC:mah]"}
{"concept_id": "C1152575", "aliases": [], "types": ["T044"], "canonical_name": "ornithine decarboxylase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of ornithine decarboxylase. [GOC:jl]"}
{"concept_id": "C1152576", "aliases": [], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. [GOC:ai]", "canonical_name": "phosphatase inhibitor activity"}
{"concept_id": "C1152577", "aliases": ["phosphoprotein phosphatase inhibitor activity"], "types": ["T044"], "canonical_name": "protein phosphatase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. [GOC:ai]"}
{"concept_id": "C1152579", "aliases": [], "types": ["T044"], "canonical_name": "pseudophosphatase activity", "definition": "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues. [GOC:ajp]"}
{"concept_id": "C1152580", "aliases": [], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. [GOC:ai, GOC:rl]", "canonical_name": "phospholipase inhibitor activity"}
{"concept_id": "C1152581", "aliases": [], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of phospholipase A2. [GOC:ai]", "canonical_name": "phospholipase A2 inhibitor activity"}
{"concept_id": "C1152582", "aliases": ["peptidase inhibitor activity"], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. [GOC:jl]", "canonical_name": "protease inhibitor activity"}
{"concept_id": "C1152585", "aliases": ["endoproteinase inhibitor"], "types": ["T044"], "canonical_name": "endopeptidase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. [GOC:jl]"}
{"concept_id": "C1152586", "aliases": ["aspartic protease inhibitor activity"], "types": ["T044"], "canonical_name": "aspartic-type endopeptidase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process. [GOC:ai]"}
{"concept_id": "C1152587", "aliases": ["thiol protease inhibitor", "cysteine protease inhibitor activity"], "types": ["T044"], "canonical_name": "cysteine-type endopeptidase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:dph, GOC:tb]"}
{"concept_id": "C1152589", "aliases": ["metalloprotease inhibitor", "metalloproteinase inhibitor"], "types": ["T044"], "canonical_name": "metalloendopeptidase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. [GOC:ai]"}
{"concept_id": "C1152590", "aliases": ["serine-type endopeptidase inhibitor activity", "serine proteinase inhibitor activity", "serine protease inhibitor activity"], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. [GOC:ai]", "canonical_name": "serpin activity"}
{"concept_id": "C1152596", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates. [ISBN:0198547684]", "canonical_name": "alpha-2 macroglobulin"}
{"concept_id": "C1152598", "aliases": ["protein biosynthetic process inhibitor activity"], "types": ["T043"], "canonical_name": "protein biosynthesis inhibitor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152599", "aliases": [], "types": ["T044"], "canonical_name": "ribonuclease inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of ribonuclease. [GOC:ai]"}
{"concept_id": "C1152600", "aliases": [], "types": ["T044"], "canonical_name": "guanylate cyclase regulator activity", "definition": "Modulates the activity of guanylate cyclase. [GOC:mah]"}
{"concept_id": "C1152601", "aliases": [], "types": ["T044"], "canonical_name": "dirigent protein"}
{"concept_id": "C1152602", "aliases": [], "types": ["T044"], "canonical_name": "kinase regulator activity", "definition": "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]"}
{"concept_id": "C1152603", "aliases": [], "types": ["T044"], "canonical_name": "protein kinase regulator activity", "definition": "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]"}
{"concept_id": "C1152604", "aliases": ["eEF-2 kinase regulator"], "types": ["T044"], "canonical_name": "eukaryotic elongation factor-2 kinase regulator activity", "definition": "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase. [GOC:jl, PMID:11904175]"}
{"concept_id": "C1152605", "aliases": ["nitric oxide synthase regulator activity"], "types": ["T044"], "canonical_name": "nitric-oxide synthase regulator activity", "definition": "Binds to and modulates the activity of nitric oxide synthase. [GOC:mah]"}
{"concept_id": "C1152606", "aliases": [], "types": ["T044"], "canonical_name": "phosphatase regulator activity", "definition": "Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. [GOC:ai]"}
{"concept_id": "C1152607", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase regulator activity", "definition": "Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. [GOC:ai]"}
{"concept_id": "C1152608", "aliases": ["ice nucleation activity"], "types": ["T044"], "canonical_name": "ice nucleation activity", "definition": "OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation. [GOC:ai, GOC:jl]"}
{"concept_id": "C1152609", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. An agent that can lyse cells. [ISBN:0198547684]", "canonical_name": "lysin activity"}
{"concept_id": "C1152610", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. An agent that can lyse the cell in which it is synthesized. [GOC:ma]", "canonical_name": "autolysin activity"}
{"concept_id": "C1152611", "aliases": ["holin"], "types": ["T044"], "definition": "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly or indirectly allows murein hydrolyases to access their cell wall substrate. [GOC:jh2, PMID:1406491, PMID:25157079]", "canonical_name": "holin activity"}
{"concept_id": "C1152612", "aliases": [], "types": ["T044"], "canonical_name": "bacteriolytic toxin activity", "definition": "OBSOLETE. Acts as to cause lysis of bacterial cells. [GOC:jl]"}
{"concept_id": "C1152613", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor. [ISBN:0198547684]", "canonical_name": "bacteriocin activity"}
{"concept_id": "C1152615", "aliases": [], "types": ["T044"], "canonical_name": "axonemal motor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1152616", "aliases": [], "types": ["T044"], "canonical_name": "kinetochore motor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1152617", "aliases": ["actin filament motor activity", "actin-dependent ATPase activity", "actin-activated ATPase activity", "actin-filament motor activity"], "types": ["T044"], "canonical_name": "microfilament motor activity", "definition": "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. [PMID:29716949]"}
{"concept_id": "C1152619", "aliases": [], "types": ["T044"], "definition": "Functions in the storage of nutritious substrates. [GOC:ai]", "canonical_name": "nutrient reservoir activity"}
{"concept_id": "C1152620", "aliases": [], "types": ["T044"], "canonical_name": "protein stabilization activity", "definition": "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds. [GOC:jid]"}
{"concept_id": "C1152621", "aliases": [], "types": ["T044"], "canonical_name": "lysosomal protein stabilization", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152623", "aliases": [], "types": ["T044"], "canonical_name": "protein tagging activity", "definition": "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation. [GOC:jl]"}
{"concept_id": "C1152624", "aliases": ["protein degradation tagging activity"], "types": ["T044"], "canonical_name": "protein degradation tagging activity", "definition": "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction. [GOC:cl, ISBN:0815316194]"}
{"concept_id": "C1152625", "aliases": [], "types": ["T044"], "canonical_name": "regulator of establishment of competence for transformation activity", "definition": "OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation. [GOC:mlg]"}
{"concept_id": "C1152626", "aliases": [], "types": ["T044"], "canonical_name": "activator of the establishment of competence for transformation activity", "definition": "OBSOLETE. Activates the establishment of competence for transformation. [GOC:mlg]"}
{"concept_id": "C1152627", "aliases": [], "types": ["T044"], "canonical_name": "inhibitor of the establishment of competence for transformation activity", "definition": "OBSOLETE. Inhibits the establishment of competence for transformation. [GOC:mlg]"}
{"concept_id": "C1152630", "aliases": [], "types": ["T044"], "canonical_name": "morphogen activity", "definition": "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. [GOC:go_curators]"}
{"concept_id": "C1152633", "aliases": [], "types": ["T044"], "canonical_name": "receptor activity"}
{"concept_id": "C1152634", "aliases": [], "types": ["T044"], "definition": "Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis. [GOC:bf, GOC:ma, PMID:6188403]", "canonical_name": "alpha-2 macroglobulin receptor activity"}
{"concept_id": "C1152635", "aliases": [], "types": ["T044"], "canonical_name": "apolipoprotein receptor activity", "definition": "Combining with an apolipoprotein to initiate a change in cell activity. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1152636", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity. [GOC:mah]", "canonical_name": "apolipoprotein E receptor activity"}
{"concept_id": "C1152638", "aliases": [], "types": ["T044"], "definition": "Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:ai, GOC:pg, GOC:signaling, ISBN:0781735149, PMID:11884446]", "canonical_name": "complement receptor activity"}
{"concept_id": "C1152639", "aliases": [], "types": ["T044"], "canonical_name": "complement component C3a receptor activity", "definition": "Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1152640", "aliases": [], "types": ["T044"], "canonical_name": "complement component C3b receptor activity", "definition": "Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1152642", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor activity", "definition": "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]"}
{"concept_id": "C1152643", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity"}
{"concept_id": "C1152644", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity"}
{"concept_id": "C1152645", "aliases": [], "types": ["T044"], "canonical_name": "diuretic hormone receptor activity", "definition": "Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity. [GOC:ai, GOC:signaling]"}
{"concept_id": "C1152647", "aliases": ["uPAR", "urokinase plasminogen activator receptor", "U-plasminogen activator receptor activity"], "types": ["T044"], "definition": "Combining with the urokinase plasminogen activator to initiate a change in cell activity. [GOC:mah, PMID:16456079]", "canonical_name": "urokinase plasminogen activator receptor activity"}
{"concept_id": "C1152648", "aliases": ["high molecular weight B lymphocyte growth factor receptor activity", "high molecular weight B-cell growth factor receptor activity", "high molecular weight B cell growth factor receptor activity", "high molecular weight B-lymphocyte growth factor receptor activity"], "types": ["T044"], "definition": "Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity. [GOC:ai, GOC:signaling, PMID:2681271]", "canonical_name": "HMW-BCGF receptor"}
{"concept_id": "C1152651", "aliases": ["nuclear hormone receptor binding", "ligand-dependent nuclear receptor binding"], "types": ["T044"], "canonical_name": "nuclear receptor binding", "definition": "Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. [PMID:7776974]"}
{"concept_id": "C1152652", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor. [PMID:7776974]", "canonical_name": "ligand-dependent thyroid hormone receptor interactor activity"}
{"concept_id": "C1152653", "aliases": [], "types": ["T044"], "definition": "Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity. [GOC:ai, GOC:signaling, PMID:10506570]", "canonical_name": "phorbol ester receptor activity"}
{"concept_id": "C1152654", "aliases": [], "types": ["T044"], "canonical_name": "non-kinase phorbol ester receptor activity", "definition": "Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity. [PMID:10506570]"}
{"concept_id": "C1152655", "aliases": [], "types": ["T044"], "definition": "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. [GOC:ai, GOC:go_curators]", "canonical_name": "photoreceptor activity"}
{"concept_id": "C1152656", "aliases": [], "types": ["T044"], "canonical_name": "blue light photoreceptor activity", "definition": "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation. [GOC:tb]"}
{"concept_id": "C1152657", "aliases": ["G protein coupled photoreceptor activity", "photoreceptor activity, G-protein coupled", "G-protein coupled photoreceptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled photoreceptor activity", "definition": "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph, ISBN:0198506732]"}
{"concept_id": "C1152658", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin. [ISBN:0198547684]", "canonical_name": "opsin"}
{"concept_id": "C1152659", "aliases": ["long-wave-sensitive opsin"], "types": ["T044"], "canonical_name": "long-wave-sensitive opsin", "definition": "OBSOLETE. An opsin with maximal absorption above 500 nm. [PMID:10594055]"}
{"concept_id": "C1152660", "aliases": ["green-sensitive opsin"], "types": ["T044"], "canonical_name": "green-sensitive opsin", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152661", "aliases": ["red-sensitive opsin"], "types": ["T044"], "canonical_name": "red-sensitive opsin", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152662", "aliases": ["short-wave-sensitive opsin"], "types": ["T044"], "canonical_name": "short-wave-sensitive opsin", "definition": "OBSOLETE. An opsin with maximal absorption between 400 and 500 nm. [PMID:10594055]"}
{"concept_id": "C1152663", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "blue-sensitive opsin"}
{"concept_id": "C1152664", "aliases": ["violet-sensitive opsin"], "types": ["T044"], "canonical_name": "violet-sensitive opsin", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152665", "aliases": ["UV-sensitive opsin"], "types": ["T044"], "canonical_name": "UV-sensitive opsin", "definition": "OBSOLETE. An opsin with maximal absorption below 400 nm. [PMID:10594055]"}
{"concept_id": "C1152666", "aliases": ["red/far-red light photoreceptor activity"], "types": ["T044"], "canonical_name": "red or far-red light photoreceptor activity", "definition": "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation. [GOC:lr]"}
{"concept_id": "C1152668", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor activity"}
{"concept_id": "C1152669", "aliases": [], "types": ["T044"], "definition": "Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane. [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein]", "canonical_name": "asialoglycoprotein receptor activity"}
{"concept_id": "C1152670", "aliases": ["receptor activity involved in axon guidance"], "types": ["T044"], "canonical_name": "axon guidance receptor activity", "definition": "Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666]"}
{"concept_id": "C1152671", "aliases": [], "types": ["T044"], "definition": "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:dph, GOC:signaling, PMID:15960985]", "canonical_name": "netrin receptor activity"}
{"concept_id": "C1152673", "aliases": [], "types": ["T044"], "canonical_name": "B cell receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1152674", "aliases": [], "types": ["T044"], "canonical_name": "cytokinin receptor activity", "definition": "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:lr, GOC:signaling]"}
{"concept_id": "C1152675", "aliases": ["G-protein coupled cytokinin receptor activity", "cytokinin receptor activity, G-protein coupled", "G protein coupled cytokinin receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled cytokinin receptor activity", "definition": "Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph]"}
{"concept_id": "C1152676", "aliases": [], "types": ["T044"], "canonical_name": "death receptor activity", "definition": "Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]"}
{"concept_id": "C1152677", "aliases": [], "types": ["T044"], "canonical_name": "death receptor adaptor protein activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152679", "aliases": [], "types": ["T044"], "canonical_name": "death receptor-associated factor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152680", "aliases": [], "types": ["T044"], "canonical_name": "decoy death receptor activity"}
{"concept_id": "C1152681", "aliases": ["tumor necrosis factor-activated receptor activity", "tumor necrosis factor receptor activity"], "types": ["T044"], "definition": "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. [GOC:jl, http://lookwayup.com/]", "canonical_name": "TNF receptor activity"}
{"concept_id": "C1152684", "aliases": [], "types": ["T044"], "canonical_name": "endogenous peptide receptor activity", "definition": "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity. [GOC:ai]"}
{"concept_id": "C1152686", "aliases": [], "types": ["T044"], "canonical_name": "HDEL receptor activity"}
{"concept_id": "C1152687", "aliases": ["KDEL sequence binding"], "types": ["T044"], "definition": "Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. [GOC:ai]", "canonical_name": "KDEL receptor activity"}
{"concept_id": "C1152688", "aliases": [], "types": ["T044"], "definition": "Binding to a signal recognition particle. [ISBN:0198506732]", "canonical_name": "signal recognition particle binding"}
{"concept_id": "C1152690", "aliases": [], "types": ["T044"], "canonical_name": "exogenous peptide receptor activity", "definition": "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity. [GOC:ai]"}
{"concept_id": "C1152691", "aliases": ["receptor activity, G-protein coupled", "GPCR activity", "G protein-coupled receptor activity", "G protein coupled receptor activity", "G-protein coupled receptor activity", "G protein linked receptor activity", "ligand-dependent GPCR activity"], "types": ["T044"], "definition": "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]", "canonical_name": "G-protein linked receptor activity"}
{"concept_id": "C1152692", "aliases": [], "types": ["T044"], "canonical_name": "bioactive lipid receptor activity", "definition": "Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770]"}
{"concept_id": "C1152696", "aliases": ["Epstein-Barr Virus-induced receptor activity"], "types": ["T044"], "canonical_name": "EBV-induced receptor"}
{"concept_id": "C1152701", "aliases": [], "types": ["T044"], "definition": "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine. [GOC:ai, ISBN:0198506732]", "canonical_name": "leukotriene receptor activity"}
{"concept_id": "C1152702", "aliases": ["CysLT receptor"], "types": ["T044"], "definition": "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine. [GOC:ai, ISBN:0198506732]", "canonical_name": "cysteinyl leukotriene receptor activity"}
{"concept_id": "C1152703", "aliases": [], "types": ["T044"], "definition": "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. [GOC:ai, ISBN:0198506732]", "canonical_name": "leukotriene B4 receptor activity"}
{"concept_id": "C1152704", "aliases": [], "types": ["T044"], "canonical_name": "Mas proto-oncogene receptor activity"}
{"concept_id": "C1152705", "aliases": ["orphanin-FQ receptor activity", "nociceptin/orphanin-FQ receptor activity", "OFQ receptor activity", "ORPH receptor"], "types": ["T044"], "canonical_name": "nociceptin receptor activity", "definition": "Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, GOC:mah, PMID:18670432]"}
{"concept_id": "C1152706", "aliases": [], "types": ["T044"], "canonical_name": "K101 receptor"}
{"concept_id": "C1152707", "aliases": [], "types": ["T044"], "canonical_name": "RDC1 receptor activity"}
{"concept_id": "C1152708", "aliases": ["super conserved receptor expressed in brain receptor activity"], "types": ["T044"], "canonical_name": "SREB receptor"}
{"concept_id": "C1152712", "aliases": ["adenylyl cyclase inhibiting metabotropic glutamate receptor activity"], "types": ["T044"], "canonical_name": "adenylate cyclase inhibiting G protein-coupled glutamate receptor activity", "definition": "Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. [GOC:bf, GOC:dph]"}
{"concept_id": "C1152713", "aliases": [], "types": ["T044"], "canonical_name": "group II metabotropic glutamate receptor activity", "definition": "A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. [GOC:dph]"}
{"concept_id": "C1152714", "aliases": [], "types": ["T044"], "canonical_name": "group III metabotropic glutamate receptor activity", "definition": "A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. [PMID:9016303]"}
{"concept_id": "C1152715", "aliases": ["group I metabotropic glutamate receptor activity"], "types": ["T044"], "canonical_name": "Group I metabotropic glutamate receptor"}
{"concept_id": "C1152716", "aliases": [], "types": ["T044"], "definition": "Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior. [GOC:hjd, ISBN:0198506732]", "canonical_name": "pheromone receptor activity"}
{"concept_id": "C1152717", "aliases": [], "types": ["T044"], "canonical_name": "mating-type factor pheromone receptor activity", "definition": "Combining with a mating-type factor pheromone to initiate a change in cell activity. [GOC:dph, GOC:vw]"}
{"concept_id": "C1152718", "aliases": [], "types": ["T044"], "canonical_name": "mating-type a-factor pheromone receptor activity", "definition": "Combining with the mating-type a-factor pheromone to initiate a change in cell activity. [GOC:mah]"}
{"concept_id": "C1152719", "aliases": [], "types": ["T044"], "canonical_name": "mating-type alpha-factor pheromone receptor activity", "definition": "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity. [GOC:mah]"}
{"concept_id": "C1152722", "aliases": ["adrenoceptor activity"], "types": ["T044"], "definition": "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]", "canonical_name": "adrenergic receptor activity"}
{"concept_id": "C1152723", "aliases": ["alpha adrenoceptor"], "types": ["T044"], "definition": "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]", "canonical_name": "alpha-adrenergic receptor activity"}
{"concept_id": "C1152724", "aliases": ["alpha1 adrenoceptor"], "types": ["T044"], "canonical_name": "alpha1-adrenergic receptor activity", "definition": "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]"}
{"concept_id": "C1152725", "aliases": ["alpha2 adrenoceptor"], "types": ["T044"], "canonical_name": "alpha2-adrenergic receptor activity", "definition": "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]"}
{"concept_id": "C1152726", "aliases": ["beta-adrenergic receptor activity"], "types": ["T044"], "definition": "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]", "canonical_name": "beta adrenoceptor"}
{"concept_id": "C1152727", "aliases": ["beta1 adrenoceptor"], "types": ["T044"], "canonical_name": "beta1-adrenergic receptor activity", "definition": "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]"}
{"concept_id": "C1152728", "aliases": ["beta2 adrenoceptor"], "types": ["T044"], "canonical_name": "beta2-adrenergic receptor activity", "definition": "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]"}
{"concept_id": "C1152729", "aliases": ["beta3 adrenoceptor"], "types": ["T044"], "canonical_name": "beta3-adrenergic receptor activity", "definition": "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]"}
{"concept_id": "C1152732", "aliases": [], "types": ["T044"], "canonical_name": "dopamine D1 receptor activity"}
{"concept_id": "C1152733", "aliases": [], "types": ["T044"], "canonical_name": "dopamine D5 receptor activity"}
{"concept_id": "C1152735", "aliases": [], "types": ["T044"], "canonical_name": "dopamine D2 receptor activity"}
{"concept_id": "C1152736", "aliases": [], "types": ["T044"], "canonical_name": "dopamine D3 receptor activity"}
{"concept_id": "C1152737", "aliases": [], "types": ["T044"], "canonical_name": "dopamine D4 receptor activity"}
{"concept_id": "C1152738", "aliases": [], "types": ["T044"], "definition": "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]", "canonical_name": "histamine receptor activity"}
{"concept_id": "C1152739", "aliases": [], "types": ["T044"], "definition": "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist. [GOC:ai]", "canonical_name": "octopamine receptor activity"}
{"concept_id": "C1152740", "aliases": ["5-HT receptor", "G-protein coupled serotonin receptor activity", "G protein-coupled serotonin receptor activity", "5-hydroxytryptamine receptor"], "types": ["T044"], "definition": "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai]", "canonical_name": "G protein coupled serotonin receptor activity"}
{"concept_id": "C1152741", "aliases": ["serotonin receptor activity, coupled via Gi/o", "Gi/o-coupled serotonin receptor activity"], "types": ["T044"], "definition": "Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels. [GOC:mah, PMID:18571247]", "canonical_name": "5-HT1 receptor activity"}
{"concept_id": "C1152742", "aliases": [], "types": ["T044"], "canonical_name": "5-HT2 receptor activity"}
{"concept_id": "C1152745", "aliases": [], "types": ["T044"], "canonical_name": "trace-amine receptor activity", "definition": "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. [GOC:mah, PMID:19325074]"}
{"concept_id": "C1152746", "aliases": [], "types": ["T044"], "definition": "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine. [GOC:curators]", "canonical_name": "tyramine receptor activity"}
{"concept_id": "C1152747", "aliases": ["cannabinoid receptor activity"], "types": ["T044"], "definition": "Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. [GOC:dph, IUPHAR_GPCR:1279, Wikipedia:Cannabinoid]", "canonical_name": "cannaboid receptor"}
{"concept_id": "C1152748", "aliases": ["eicosanoid receptor activity"], "types": ["T044"], "definition": "Combining with an icosanoid to initiate a change in cell activity. [GOC:dph]", "canonical_name": "icosanoid receptor activity"}
{"concept_id": "C1152749", "aliases": [], "types": ["T044"], "canonical_name": "prostanoid receptor activity", "definition": "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity. [ISBN:0198506732]"}
{"concept_id": "C1152750", "aliases": ["PGI receptor activity", "prostaglandin I receptor activity", "PGI(2) receptor activity"], "types": ["T044"], "canonical_name": "prostacyclin receptor activity", "definition": "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity. [ISBN:0198506732]"}
{"concept_id": "C1152751", "aliases": [], "types": ["T044"], "definition": "Combining with a prostaglandin (PG) to initiate a change in cell activity. [ISBN:0198506732]", "canonical_name": "prostaglandin receptor activity"}
{"concept_id": "C1152752", "aliases": ["prostaglandin D receptor activity", "PGD receptor activity"], "types": ["T044"], "definition": "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity. [ISBN:0198506732]", "canonical_name": "PGD(2) receptor activity"}
{"concept_id": "C1152753", "aliases": ["PGE(2) receptor activity", "prostaglandin E receptor activity"], "types": ["T044"], "definition": "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. [ISBN:0198506732]", "canonical_name": "PGE receptor activity"}
{"concept_id": "C1152754", "aliases": ["PGF(2-alpha) receptor activity", "PGF receptor activity"], "types": ["T044"], "canonical_name": "prostaglandin F receptor activity", "definition": "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity. [ISBN:0198506732]"}
{"concept_id": "C1152756", "aliases": ["thromboxane receptor activity"], "types": ["T044"], "definition": "Combining with a thromboxane (TXA) to initiate a change in cell activity. [ISBN:0198506732]", "canonical_name": "TXA receptor activity"}
{"concept_id": "C1152757", "aliases": ["thromboxane A2 receptor activity", "TXA(2) receptor activity"], "types": ["T044"], "definition": "Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein. [GOC:signaling, ISBN:0198506732]", "canonical_name": "TXA2 receptor activity"}
{"concept_id": "C1152758", "aliases": [], "types": ["T044"], "definition": "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. [GOC:ai, ISBN:0198506732]", "canonical_name": "melatonin receptor activity"}
{"concept_id": "C1152759", "aliases": ["G-protein coupled nucleotide receptor activity", "nucleotide receptor activity, G-protein coupled", "nucleotide receptor activity, G protein coupled", "G protein coupled nucleotide receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled nucleotide receptor activity", "definition": "Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph, IUPHAR_GPCR:1294]"}
{"concept_id": "C1152760", "aliases": ["G protein coupled purinergic nucleotide receptor activity", "purinergic nucleotide receptor activity, G-protein coupled", "purinergic nucleotide receptor activity, G protein coupled", "P2Y receptor", "P2Y", "G-protein coupled purinergic nucleotide receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled purinergic nucleotide receptor activity", "definition": "Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, PMID:9755289]"}
{"concept_id": "C1152761", "aliases": ["G-protein coupled adenosine receptor activity", "P1 receptor", "G protein coupled adenosine receptor activity", "adenosine receptor activity, G-protein coupled", "adenosine receptor activity, G protein coupled"], "types": ["T044"], "canonical_name": "G protein-coupled adenosine receptor activity", "definition": "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah, PMID:9755289]"}
{"concept_id": "C1152762", "aliases": ["G protein coupled A1 adenosine receptor activity", "A1 adenosine receptor activity, G protein coupled", "G-protein-coupled A1 adenosine receptor activity"], "types": ["T044"], "canonical_name": "A1 adenosine receptor activity, G-protein coupled"}
{"concept_id": "C1152763", "aliases": ["G-protein-coupled A2A adenosine receptor activity", "A2A adenosine receptor activity, G protein coupled", "G protein coupled A2A adenosine receptor activity"], "types": ["T044"], "canonical_name": "A2A adenosine receptor activity, G-protein coupled"}
{"concept_id": "C1152764", "aliases": ["A2B adenosine receptor activity, G protein coupled", "G protein coupled A2B adenosine receptor activity", "G-protein-coupled A2B adenosine receptor activity"], "types": ["T044"], "canonical_name": "A2B adenosine receptor activity, G-protein coupled"}
{"concept_id": "C1152765", "aliases": ["A3 adenosine receptor activity, G protein coupled", "G-protein-coupled A3 adenosine receptor activity", "G protein coupled A3 adenosine receptor activity"], "types": ["T044"], "canonical_name": "A3 adenosine receptor activity, G-protein coupled"}
{"concept_id": "C1152766", "aliases": [], "types": ["T044"], "canonical_name": "ADP-activated nucleotide receptor activity"}
{"concept_id": "C1152767", "aliases": [], "types": ["T044"], "canonical_name": "ATP-activated nucleotide receptor activity"}
{"concept_id": "C1152769", "aliases": [], "types": ["T044"], "canonical_name": "UDP-activated nucleotide receptor activity"}
{"concept_id": "C1152770", "aliases": [], "types": ["T044"], "canonical_name": "UTP-activated nucleotide receptor activity"}
{"concept_id": "C1152771", "aliases": ["odorant receptor activity"], "types": ["T044"], "definition": "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]", "canonical_name": "olfactory receptor activity"}
{"concept_id": "C1152772", "aliases": ["PAF receptor activity"], "types": ["T044"], "definition": "Combining with platelet activating factor to initiate a change in cell activity. [GOC:mah]", "canonical_name": "platelet activating factor receptor activity"}
{"concept_id": "C1152773", "aliases": [], "types": ["T044"], "canonical_name": "protein-hormone receptor activity", "definition": "Combining with a protein hormone to initiate a change in cell activity. [GOC:mah]"}
{"concept_id": "C1152774", "aliases": ["follicle stimulating hormone receptor activity", "follicle-stimulating hormone receptor activity"], "types": ["T044"], "definition": "Combining with follicle-stimulating hormone to initiate a change in cell activity. [GOC:mah]", "canonical_name": "FSH receptor activity"}
{"concept_id": "C1152775", "aliases": ["GnRH receptor activity", "gonadotrophin-releasing hormone receptor activity"], "types": ["T044"], "definition": "Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. [GOC:mah]", "canonical_name": "gonadotropin-releasing hormone receptor activity"}
{"concept_id": "C1152776", "aliases": [], "types": ["T044"], "canonical_name": "lutropin-choriogonadotropic hormone receptor"}
{"concept_id": "C1152777", "aliases": ["MCH receptor"], "types": ["T044"], "definition": "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity. [GOC:mah]", "canonical_name": "melanin-concentrating hormone receptor activity"}
{"concept_id": "C1152778", "aliases": ["TSH receptor activity", "thyroid-stimulating hormone receptor activity", "thyroid stimulating hormone receptor activity"], "types": ["T044"], "definition": "Combining with thyroid-stimulating hormone to initiate a change in cell activity. [GOC:mah]", "canonical_name": "thyrotropin receptor"}
{"concept_id": "C1152779", "aliases": ["taste receptor activity"], "types": ["T044"], "definition": "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. [GOC:dph]", "canonical_name": "gustatory receptor"}
{"concept_id": "C1152781", "aliases": ["ghrelin receptor activity"], "types": ["T044"], "definition": "Combining with ghrelin to initiate a change in cell activity. [GOC:mah, PMID:17983853]", "canonical_name": "growth hormone secretagogue receptor activity"}
{"concept_id": "C1152783", "aliases": [], "types": ["T044"], "canonical_name": "thyrotropin-releasing hormone receptor activity", "definition": "Combining with thyrotropin-releasing hormone to initiate a change in cell activity. [GOC:mah]"}
{"concept_id": "C1152784", "aliases": ["viral receptor activity"], "types": ["T044"], "canonical_name": "virus receptor activity", "definition": "Combining with a virus component and mediating entry of the virus into the cell. [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183]"}
{"concept_id": "C1152787", "aliases": ["calcitonin gene-related polypeptide receptor activity", "calcitonin gene-related peptide receptor activity"], "types": ["T044"], "definition": "Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. [GOC:mah, PMID:12037140]", "canonical_name": "CGRP receptor"}
{"concept_id": "C1152788", "aliases": [], "types": ["T044"], "definition": "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, GOC:signaling, PMID:21649645]", "canonical_name": "calcitonin receptor activity"}
{"concept_id": "C1152790", "aliases": [], "types": ["T044"], "canonical_name": "corticotrophin-releasing factor receptor activity", "definition": "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. [PMID:12032352]"}
{"concept_id": "C1152791", "aliases": ["glucose-dependent insulinotropic polypeptide receptor activity", "GIP receptor activity"], "types": ["T044"], "canonical_name": "gastric inhibitory peptide receptor activity", "definition": "Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein. [GOC:mah, PMID:8243312]"}
{"concept_id": "C1152793", "aliases": [], "types": ["T044"], "definition": "Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, GOC:signaling, PMID:22438981]", "canonical_name": "glucagon receptor activity"}
{"concept_id": "C1152794", "aliases": [], "types": ["T044"], "definition": "Combining with growth hormone-releasing hormone to initiate a change in cell activity. [PMID:12529933]", "canonical_name": "growth hormone-releasing hormone receptor activity"}
{"concept_id": "C1152795", "aliases": [], "types": ["T044"], "definition": "Combining with parathyroid hormone to initiate a change in cell activity. [GOC:mah]", "canonical_name": "parathyroid hormone receptor activity"}
{"concept_id": "C1152796", "aliases": ["pituitary adenylyl cyclase activating protein receptor activity", "pituitary adenylate cyclase activating polypeptide receptor", "PACAP receptor", "pituitary adenylate cyclase-activating polypeptide receptor activity"], "types": ["T044"], "definition": "A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide. [GOC:dph, GOC:tb]", "canonical_name": "pituitary adenylate cyclase activating protein receptor activity"}
{"concept_id": "C1152797", "aliases": [], "types": ["T044"], "definition": "Combining with secretin to initiate a change in cell activity. [GOC:mah]", "canonical_name": "secretin receptor activity"}
{"concept_id": "C1152798", "aliases": [], "types": ["T044"], "canonical_name": "vasoactive intestinal polypeptide receptor activity", "definition": "Combining with vasoactive intestinal polypeptide to initiate a change in cell activity. [GOC:mah]"}
{"concept_id": "C1152799", "aliases": [], "types": ["T044"], "definition": "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]", "canonical_name": "glutamate receptor activity"}
{"concept_id": "C1152801", "aliases": ["extracellular-glutamate-gated chloride channel activity"], "types": ["T044"], "canonical_name": "extracellularly glutamate-gated chloride channel activity", "definition": "Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1152802", "aliases": [], "types": ["T044"], "canonical_name": "ionotropic glutamate receptor activity", "definition": "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. [ISBN:0198506732]"}
{"concept_id": "C1152803", "aliases": ["alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity", "AMPA receptor activity"], "types": ["T044"], "canonical_name": "AMPA glutamate receptor activity", "definition": "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium. [GOC:mah, PMID:10049997, PMID:8804111]"}
{"concept_id": "C1152804", "aliases": [], "types": ["T044"], "canonical_name": "kainate selective glutamate receptor activity", "definition": "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist. [GOC:mah, PMID:10049997, PMID:8804111]"}
{"concept_id": "C1152805", "aliases": ["N-methyl-D-aspartate selective glutamate receptor activity", "NMDA glutamate receptor activity"], "types": ["T044"], "definition": "An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages. [GOC:mah, PMID:10049997]", "canonical_name": "NMDA receptor"}
{"concept_id": "C1152807", "aliases": [], "types": ["T044"], "canonical_name": "hematopoietin/interferon-class (D200-domain) cytokine receptor activity"}
{"concept_id": "C1152808", "aliases": ["ciliary neurotrophic factor receptor activity"], "types": ["T044"], "definition": "Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]", "canonical_name": "CNTF receptor activity"}
{"concept_id": "C1152809", "aliases": [], "types": ["T044"], "canonical_name": "leukemia inhibitory factor receptor beta-protein activity"}
{"concept_id": "C1152810", "aliases": [], "types": ["T044"], "definition": "Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]", "canonical_name": "erythropoietin receptor activity"}
{"concept_id": "C1152811", "aliases": ["glial cell line-derived neurotrophic factor receptor activity", "GDNF receptor activity"], "types": ["T044"], "canonical_name": "glial cell-derived neurotrophic factor receptor activity", "definition": "Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]"}
{"concept_id": "C1152812", "aliases": [], "types": ["T044"], "definition": "Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]", "canonical_name": "growth hormone receptor activity"}
{"concept_id": "C1152813", "aliases": ["leukemia inhibitory factor receptor activity"], "types": ["T044"], "definition": "Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:mah, GOC:signaling]", "canonical_name": "LIF receptor activity"}
{"concept_id": "C1152814", "aliases": [], "types": ["T044"], "canonical_name": "oncostatin-M receptor activity", "definition": "Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]"}
{"concept_id": "C1152815", "aliases": [], "types": ["T044"], "definition": "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]", "canonical_name": "prolactin receptor activity"}
{"concept_id": "C1152816", "aliases": ["immunoglobulin receptor activity"], "types": ["T044"], "definition": "Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling, ISBN:0198547684]", "canonical_name": "FC receptor activity"}
{"concept_id": "C1152817", "aliases": [], "types": ["T044"], "definition": "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling, PMID:10025961]", "canonical_name": "latrotoxin receptor activity"}
{"concept_id": "C1152818", "aliases": ["lipoprotein receptor activity", "lipoprotein particle receptor activity"], "types": ["T044"], "definition": "Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. [GOC:bf, GOC:mah, PMID:12827279]", "canonical_name": "plasma lipoprotein particle receptor activity"}
{"concept_id": "C1152819", "aliases": ["very-low-density lipoprotein particle receptor activity", "VLDL receptor"], "types": ["T044"], "definition": "Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis. [GOC:bf, ISBN:0198506732]", "canonical_name": "very-low-density lipoprotein receptor activity"}
{"concept_id": "C1152821", "aliases": [], "types": ["T044"], "canonical_name": "HLA-A specific activating MHC class I receptor activity", "definition": "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte. [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]"}
{"concept_id": "C1152822", "aliases": [], "types": ["T044"], "canonical_name": "HLA-A specific inhibitory MHC class I receptor activity", "definition": "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]"}
{"concept_id": "C1152823", "aliases": [], "types": ["T044"], "canonical_name": "HLA-B specific inhibitory MHC class I receptor activity", "definition": "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte. [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]"}
{"concept_id": "C1152824", "aliases": [], "types": ["T044"], "canonical_name": "HLA-C specific inhibitory MHC class I receptor activity", "definition": "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte. [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]"}
{"concept_id": "C1152827", "aliases": ["neurotensin receptor activity, non-G-protein coupled", "non G protein coupled neurotensin receptor activity", "neurotensin receptor activity, non G protein coupled", "non-G-protein-coupled neurotensin receptor activity", "non-G-protein coupled neurotensin receptor activity"], "types": ["T044"], "canonical_name": "neurotensin receptor activity, non-G protein-coupled", "definition": "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins. [GOC:mah, GOC:signaling, PMID:9756851]"}
{"concept_id": "C1152828", "aliases": [], "types": ["T044"], "canonical_name": "NGF/TNF (6 C-domain) receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1152829", "aliases": [], "types": ["T044"], "canonical_name": "CD27 receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1152830", "aliases": [], "types": ["T044"], "canonical_name": "CD40 receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1152834", "aliases": ["frizzled-2 receptor activity"], "types": ["T044"], "canonical_name": "frizzled receptor activity", "definition": "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity. [GOC:go_curators]"}
{"concept_id": "C1152835", "aliases": ["patched activity"], "types": ["T044"], "canonical_name": "hedgehog receptor activity", "definition": "Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity. [GOC:bf, GOC:go_curators, PMID:9278137]"}
{"concept_id": "C1152836", "aliases": [], "types": ["T044"], "canonical_name": "sevenless receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1152837", "aliases": ["non-tyrosine kinase FGFR activity", "non-tyrosine kinase FGF receptor activity"], "types": ["T044"], "canonical_name": "non-tyrosine kinase fibroblast growth factor receptor activity", "definition": "Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity. [GOC:signaling, PMID:11418238]"}
{"concept_id": "C1152838", "aliases": ["NES receptor"], "types": ["T044"], "canonical_name": "nuclear export signal receptor activity", "definition": "Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein. [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]"}
{"concept_id": "C1152839", "aliases": [], "types": ["T044"], "canonical_name": "nucleotide receptor activity", "definition": "Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. [GOC:signaling, ISBN:0198506732]"}
{"concept_id": "C1152840", "aliases": ["purinoreceptor", "purinergic nucleotide receptor activity", "purinoceptor"], "types": ["T044"], "definition": "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]", "canonical_name": "P2 receptor"}
{"concept_id": "C1152842", "aliases": [], "types": ["T044"], "canonical_name": "osmosensor activity", "definition": "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C1152843", "aliases": [], "types": ["T044"], "canonical_name": "signaling pattern recognition receptor activity"}
{"concept_id": "C1152844", "aliases": ["pentaxin receptor"], "types": ["T044"], "canonical_name": "pentraxin receptor activity", "definition": "Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1152845", "aliases": ["neuronal pentaxin receptor"], "types": ["T044"], "definition": "Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:18840757]", "canonical_name": "neuronal pentraxin receptor activity"}
{"concept_id": "C1152846", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan receptor activity"}
{"concept_id": "C1152847", "aliases": [], "types": ["T044"], "canonical_name": "ribosome receptor activity"}
{"concept_id": "C1152848", "aliases": [], "types": ["T044"], "definition": "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]", "canonical_name": "scavenger receptor activity"}
{"concept_id": "C1152849", "aliases": [], "types": ["T044"], "canonical_name": "semaphorin receptor activity", "definition": "Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:15239958]"}
{"concept_id": "C1152850", "aliases": ["sulfonylurea receptor activity"], "types": ["T044"], "definition": "Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]", "canonical_name": "sulphonylurea receptor activity"}
{"concept_id": "C1152851", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "T cell receptor activity"}
{"concept_id": "C1152852", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "alpha-beta T cell receptor activity"}
{"concept_id": "C1152853", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "gamma-delta T cell receptor activity"}
{"concept_id": "C1152854", "aliases": [], "types": ["T044"], "canonical_name": "tiggrin receptor activity", "definition": "Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:9521906]"}
{"concept_id": "C1152855", "aliases": [], "types": ["T044"], "definition": "Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates. [GOC:bf, PMID:2678449, PMID:3011819]", "canonical_name": "transferrin receptor activity"}
{"concept_id": "C1152856", "aliases": [], "types": ["T044"], "canonical_name": "vasopressin activated calcium mobilizing receptor activity"}
{"concept_id": "C1152858", "aliases": [], "types": ["T044"], "definition": "Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis. [GOC:bf, PMID:12429745]", "canonical_name": "vitellogenin receptor activity"}
{"concept_id": "C1152862", "aliases": [], "types": ["T044"], "canonical_name": "receptor regulator activity"}
{"concept_id": "C1152863", "aliases": [], "types": ["T044"], "canonical_name": "acetylcholine receptor regulator activity", "definition": "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed. [GOC:mah]"}
{"concept_id": "C1152864", "aliases": [], "types": ["T044"], "canonical_name": "acetylcholine receptor activator activity", "definition": "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased. [GOC:mah]"}
{"concept_id": "C1152865", "aliases": [], "types": ["T044"], "canonical_name": "acetylcholine receptor inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of an acetylcholine receptor. [GOC:mah]"}
{"concept_id": "C1152866", "aliases": [], "types": ["T044"], "canonical_name": "receptor activator activity"}
{"concept_id": "C1152867", "aliases": [], "types": ["T044"], "canonical_name": "receptor inhibitor activity"}
{"concept_id": "C1152868", "aliases": ["receptor signaling complex adaptor activity", "receptor signaling complex scaffold activity", "receptor signalling complex scaffold activity", "receptor signaling complex scaffold protein activity", "receptor signalling complex adaptor activity"], "types": ["T044"], "canonical_name": "signaling receptor complex adaptor activity", "definition": "The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex. [GOC:mah]"}
{"concept_id": "C1152869", "aliases": ["postsynaptic density scaffold protein"], "types": ["T044"], "canonical_name": "GKAP/Homer scaffold protein"}
{"concept_id": "C1152870", "aliases": ["MAP-kinase scaffold protein activity"], "types": ["T044"], "canonical_name": "MAP-kinase scaffold activity", "definition": "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently. [PMID:12511654, PMID:15213240, PMID:9405336]"}
{"concept_id": "C1152872", "aliases": [], "types": ["T044"], "canonical_name": "MAP-kinase anchoring activity", "definition": "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location. [GOC:ai]"}
{"concept_id": "C1152873", "aliases": ["protein kinase A anchoring activity"], "types": ["T044"], "canonical_name": "protein kinase A anchoring activity", "definition": "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location. [PMID:10354567]"}
{"concept_id": "C1152874", "aliases": ["PKC alpha binding", "protein kinase C alpha binding", "PKC binding", "PKC eta binding", "protein kinase C eta binding", "protein kinase C delta binding", "PKC delta binding"], "types": ["T044"], "canonical_name": "protein kinase C binding", "definition": "Binding to protein kinase C. [GOC:jl]"}
{"concept_id": "C1152875", "aliases": [], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor anchoring activity", "definition": "OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location. [GOC:ai]"}
{"concept_id": "C1152878", "aliases": [], "types": ["T044"], "canonical_name": "JAK pathway signal transduction adaptor activity", "definition": "The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07]"}
{"concept_id": "C1152880", "aliases": ["small GTPase regulator activity"], "types": ["T044"], "canonical_name": "small GTPase regulatory/interacting protein activity"}
{"concept_id": "C1152881", "aliases": ["GDI"], "types": ["T044"], "canonical_name": "GDP-dissociation inhibitor activity", "definition": "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. [GOC:mah]"}
{"concept_id": "C1152882", "aliases": [], "types": ["T044"], "canonical_name": "Rab GDP-dissociation inhibitor activity", "definition": "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. [GOC:mah]"}
{"concept_id": "C1152883", "aliases": [], "types": ["T044"], "canonical_name": "Rho GDP-dissociation inhibitor activity", "definition": "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. [GOC:mah]"}
{"concept_id": "C1152886", "aliases": [], "types": ["T044"], "canonical_name": "guanyl-nucleotide exchange factor adaptor activity", "definition": "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]"}
{"concept_id": "C1152898", "aliases": ["transmembrane receptor protein tyrosine kinase adaptor protein activity"], "types": ["T044"], "canonical_name": "transmembrane receptor protein tyrosine kinase adaptor activity", "definition": "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848]"}
{"concept_id": "C1152899", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor protein tyrosine kinase docking protein activity"}
{"concept_id": "C1152901", "aliases": [], "types": ["T044"], "canonical_name": "receptor-associated protein activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152906", "aliases": [], "types": ["T044"], "definition": "The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. [GOC:mah, GOC:vw]", "canonical_name": "structural molecule activity"}
{"concept_id": "C1152909", "aliases": [], "types": ["T044"], "canonical_name": "extracellular matrix constituent, lubricant activity", "definition": "Functions as a lubricant for an extracellular matrix, such as a mucous membrane. [GOC:mah]"}
{"concept_id": "C1152913", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of bone", "definition": "The action of a molecule that contributes to the structural integrity of bone. [GOC:mah]"}
{"concept_id": "C1152914", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of cell wall", "definition": "The action of a molecule that contributes to the structural integrity of a cell wall. [GOC:mah]"}
{"concept_id": "C1152915", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of chorion"}
{"concept_id": "C1152916", "aliases": [], "types": ["T045"], "canonical_name": "structural constituent of chromatin", "definition": "The action of a molecule that contributes to the structural integrity of chromatin. [GOC:ai]"}
{"concept_id": "C1152917", "aliases": ["structural constituent of cuticle"], "types": ["T044"], "canonical_name": "structural constituent of cuticle", "definition": "The action of a molecule that contributes to the structural integrity of a cuticle. [GOC:jl]"}
{"concept_id": "C1152918", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of chitin-based cuticle", "definition": "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1152919", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of adult chitin-based cuticle", "definition": "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1152920", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of chitin-based larval cuticle", "definition": "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1152921", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of pupal chitin-based cuticle", "definition": "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1152922", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of collagen and cuticulin-based cuticle", "definition": "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1152923", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of cytoskeleton", "definition": "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. [GOC:mah]"}
{"concept_id": "C1152924", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of epidermis"}
{"concept_id": "C1152925", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of cutaneous appendage", "definition": "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers. [GOC:mah, ISBN:0878932437]"}
{"concept_id": "C1152926", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of eye lens", "definition": "The action of a molecule that contributes to the structural integrity of the lens of an eye. [GOC:mah]"}
{"concept_id": "C1152927", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of muscle", "definition": "The action of a molecule that contributes to the structural integrity of a muscle fiber. [GOC:mah]"}
{"concept_id": "C1152928", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of myelin sheath", "definition": "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve. [GOC:mah]"}
{"concept_id": "C1152929", "aliases": ["nucleocytoplasmic transporter activity"], "types": ["T044"], "canonical_name": "structural constituent of nuclear pore", "definition": "The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules. [GOC:mah, PMID:25802992]"}
{"concept_id": "C1152930", "aliases": ["structural constituent of peritrophic matrix"], "types": ["T044"], "canonical_name": "structural constituent of peritrophic membrane", "definition": "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1152931", "aliases": [], "types": ["T044"], "definition": "The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah]", "canonical_name": "structural constituent of ribosome"}
{"concept_id": "C1152932", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of tooth enamel", "definition": "The action of a molecule that contributes to the structural integrity of tooth enamel. [GOC:mah]"}
{"concept_id": "C1152934", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. The action of reducing the surface tension of a liquid. [GOC:jl, ISBN:0198506732]", "canonical_name": "surfactant activity"}
{"concept_id": "C1152941", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species. [GOC:jl, ISBN:0198506732]", "canonical_name": "conotoxin activity"}
{"concept_id": "C1152942", "aliases": ["pore-forming toxin activity"], "types": ["T044"], "canonical_name": "pore-forming toxin activity", "definition": "OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell. [PMID:10839820]"}
{"concept_id": "C1152943", "aliases": ["channel-forming toxin activity"], "types": ["T044"], "canonical_name": "channel-forming toxin activity", "definition": "OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell. [GOC:ai]"}
{"concept_id": "C1152944", "aliases": [], "types": ["T044"], "canonical_name": "transcription regulator activity", "definition": "OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. [GOC:mah]"}
{"concept_id": "C1152945", "aliases": ["translation factor activity"], "types": ["T045"], "canonical_name": "translation regulator activity", "definition": "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. [GOC:ai]"}
{"concept_id": "C1152946", "aliases": [], "types": ["T045"], "canonical_name": "translation factor activity, non-nucleic acid binding", "definition": "A translation regulator activity that does not involve binding to nucleic acids. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1152947", "aliases": [], "types": ["T045"], "canonical_name": "translation repressor activity, non-nucleic acid binding", "definition": "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid. [GOC:clt]"}
{"concept_id": "C1152948", "aliases": [], "types": ["T045"], "canonical_name": "translation repressor activity", "definition": "Antagonizes ribosome-mediated translation of mRNA into a polypeptide. [GOC:ai, GOC:clt]"}
{"concept_id": "C1152949", "aliases": [], "types": ["T044"], "definition": "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. [GOC:ai, GOC:dgf]", "canonical_name": "transporter activity"}
{"concept_id": "C1152950", "aliases": ["amine/polyamine transmembrane transporter activity", "amino acid-polyamine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "amine transmembrane transporter activity", "definition": "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1152951", "aliases": [], "types": ["T044"], "canonical_name": "acetylcholine transmembrane transporter activity", "definition": "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai]"}
{"concept_id": "C1152952", "aliases": ["acetylcholine:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "acetylcholine:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out). [TC:2.A.1.2.13]"}
{"concept_id": "C1152953", "aliases": ["betaine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "amino-acid betaine transmembrane transporter activity", "definition": "Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid. [GOC:ai]"}
{"concept_id": "C1152957", "aliases": ["choline permease activity"], "types": ["T044"], "canonical_name": "choline transmembrane transporter activity", "definition": "Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:ai]"}
{"concept_id": "C1152958", "aliases": ["amino acid/choline transmembrane transporter activity"], "types": ["T044"], "canonical_name": "amino acid/choline transmembrane transporter activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152961", "aliases": ["sodium/choline symporter activity"], "types": ["T044"], "canonical_name": "choline:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in). [TC:2.A.22.3.5]"}
{"concept_id": "C1152964", "aliases": ["dopamine transmembrane transporter activity", "sodium/dopamine symporter activity", "dopamine:sodium:chloride symporter activity"], "types": ["T044"], "canonical_name": "dopamine:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in). [PMID:21752877, PMID:22519513, TC:2.A.22.1.3]"}
{"concept_id": "C1152968", "aliases": ["monoamine:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "monoamine:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out). [TC:2.A.1.2.11, TC:2.A.1.2.12]"}
{"concept_id": "C1152969", "aliases": ["norepinephrine:sodium:chloride symporter activity", "noradrenaline transporter activity", "sodium/norepinephrine symporter activity", "norepinephrine transmembrane transporter activity", "norepinephrine:sodium symporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in). [PMID:21752877, PMID:22519513, TC:2.A.22.1.2]", "canonical_name": "levarterenol transporter activity"}
{"concept_id": "C1152971", "aliases": [], "types": ["T044"], "canonical_name": "polyamine transmembrane transporter activity", "definition": "Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1152973", "aliases": ["amino acid transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "amino acid permease activity"}
{"concept_id": "C1152976", "aliases": ["asparagine/glutamine permease activity"], "types": ["T044"], "canonical_name": "asparagine/glutamine permease activity", "definition": "OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane. [GOC:ai]"}
{"concept_id": "C1152977", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity basic amino acid transporter activity"}
{"concept_id": "C1152978", "aliases": [], "types": ["T044"], "canonical_name": "high affinity glutamine permease activity"}
{"concept_id": "C1152979", "aliases": [], "types": ["T044"], "canonical_name": "high affinity histidine permease activity"}
{"concept_id": "C1152980", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity arginine transporter activity"}
{"concept_id": "C1152981", "aliases": [], "types": ["T044"], "canonical_name": "high affinity lysine transporter activity"}
{"concept_id": "C1152982", "aliases": ["L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity", "L-lysine exporter activity"], "types": ["T044"], "canonical_name": "L-lysine efflux transmembrane transporter activity", "definition": "Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1152983", "aliases": [], "types": ["T044"], "canonical_name": "lysine permease activity"}
{"concept_id": "C1152984", "aliases": [], "types": ["T044"], "canonical_name": "general amino acid permease activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1152985", "aliases": ["amino acid:cation symporter activity", "cation:amino acid symporter activity", "cation/amino acid symporter"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). [GOC:ai]", "canonical_name": "cation/amino acid symporter activity"}
{"concept_id": "C1152986", "aliases": [], "types": ["T044"], "canonical_name": "branched-chain amino acid:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in). [TC:2.A.26.1.1]"}
{"concept_id": "C1152987", "aliases": ["isoleucine/valine:sodium symporter activity"], "types": ["T044"], "canonical_name": "isoleucine/valine:sodium symporter activity", "definition": "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in). [TC:2.A.26.1.1]"}
{"concept_id": "C1152988", "aliases": ["amino acid:proton symporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). [GOC:ai]", "canonical_name": "hydrogen:amino acid symporter activity"}
{"concept_id": "C1152989", "aliases": ["aromatic amino acid:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "aromatic amino acid:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in). [TC:2.A.3.1.3]"}
{"concept_id": "C1152990", "aliases": ["gamma-aminobutyric acid permease activity", "gamma-aminobutyric acid:hydrogen symporter activity", "4-aminobutyrate:proton symporter activity", "4-aminobutanoate:hydrogen symporter activity", "GABA:hydrogen symporter activity", "4-aminobutyrate:hydrogen symporter activity", "4-aminobutanoate:proton symporter activity", "GABA:proton symporter activity"], "types": ["T044"], "canonical_name": "gamma-aminobutyric acid:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in). [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2]"}
{"concept_id": "C1152991", "aliases": ["lysine:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "lysine:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in). [TC:2.A.3.1.2]"}
{"concept_id": "C1152992", "aliases": ["phenylalanine:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "phenylalanine:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in). [TC:2.A.3.1.1]"}
{"concept_id": "C1152993", "aliases": ["proline/glycine/betaine:hydrogen/sodium symporter activity"], "types": ["T044"], "canonical_name": "proline/glycine/betaine:hydrogen/sodium symporter activity", "definition": "OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in). [TC:2.A.1.6.4]"}
{"concept_id": "C1152994", "aliases": [], "types": ["T044"], "canonical_name": "cationic amino acid transmembrane transporter activity"}
{"concept_id": "C1152995", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity glutamate transporter activity"}
{"concept_id": "C1152996", "aliases": ["hydroxy/aromatic amino acid permease activity"], "types": ["T044"], "canonical_name": "hydroxy/aromatic amino acid permease activity", "definition": "OBSOLETE. Permease for hydroxy and aromatic amino acids. [GOC:ai]"}
{"concept_id": "C1153000", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity tryptophan transporter activity"}
{"concept_id": "C1153003", "aliases": ["leucine/valine/isoleucine permease activity"], "types": ["T044"], "canonical_name": "leucine/valine/isoleucine permease activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153004", "aliases": ["threonine efflux permease activity", "threonine export transporter activity"], "types": ["T044"], "canonical_name": "threonine efflux transmembrane transporter activity", "definition": "Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153005", "aliases": ["p-aminobenzoyl-glutamate uptake permease activity"], "types": ["T044"], "canonical_name": "p-aminobenzoyl-glutamate uptake transmembrane transporter activity"}
{"concept_id": "C1153010", "aliases": [], "types": ["T044"], "canonical_name": "neutral L-amino acid porter activity"}
{"concept_id": "C1153011", "aliases": ["sodium:alanine symporter activity"], "types": ["T044"], "canonical_name": "alanine:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in). [GOC:ai]"}
{"concept_id": "C1153012", "aliases": ["cystine porter activity", "lysosomal cystine transporter"], "types": ["T044"], "canonical_name": "cystinosin"}
{"concept_id": "C1153013", "aliases": [], "types": ["T044"], "canonical_name": "cystine:glutamate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out). [TC:2.A.3.8.5]"}
{"concept_id": "C1153014", "aliases": [], "types": ["T044"], "canonical_name": "glycine:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in). [GOC:ai]"}
{"concept_id": "C1153015", "aliases": [], "types": ["T044"], "canonical_name": "L-methionine porter activity"}
{"concept_id": "C1153017", "aliases": ["putrescine:hydrogen symporter activity", "putrescine-ornithine antiporter activity", "putrescine/ornithine antiporter activity"], "types": ["T044"], "canonical_name": "putrescine:ornithine antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out). [TC:2.A.3.2.1]"}
{"concept_id": "C1153019", "aliases": ["S-methylmethionine permease activity"], "types": ["T044"], "definition": "Enables the transfer of S-methylmethionine from one side of a membrane to the other. [GOC:ai]", "canonical_name": "S-methylmethionine transmembrane transporter activity"}
{"concept_id": "C1153020", "aliases": ["sodium:amino acid symporter activity", "sodium/excitatory amino acid symporter activity", "sodium:amino acid transporter activity", "sodium/amino acid transporter activity", "sodium/excitatory amino acid cotransporter activity"], "types": ["T044"], "canonical_name": "amino acid:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). [GOC:ai]"}
{"concept_id": "C1153021", "aliases": ["insulin-activated sodium:amino acid symporter activity", "insulin-activated sodium:amino acid transporter activity"], "types": ["T044"], "canonical_name": "insulin-activated sodium/amino acid transporter activity"}
{"concept_id": "C1153022", "aliases": ["sodium/neutral amino acid transporter"], "types": ["T044"], "canonical_name": "neutral amino acid-sodium cotransporter"}
{"concept_id": "C1153023", "aliases": [], "types": ["T044"], "canonical_name": "neutral, cationic amino acid:sodium:chloride symporter activity"}
{"concept_id": "C1153024", "aliases": ["polyamine:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "polyamine:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out). [TC:2.A.1.2.16]"}
{"concept_id": "C1153031", "aliases": [], "types": ["T044"], "canonical_name": "taurine transmembrane transporter activity", "definition": "Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. [GOC:ai]"}
{"concept_id": "C1153032", "aliases": [], "types": ["T044"], "canonical_name": "taurine:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). [TC:2.A.22.3.3]"}
{"concept_id": "C1153033", "aliases": [], "types": ["T044"], "canonical_name": "urea transporter activity"}
{"concept_id": "C1153034", "aliases": ["urea active transmembrane transporter activity"], "types": ["T044"], "canonical_name": "urea:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in). [TC:2.A.21.6.1]"}
{"concept_id": "C1153035", "aliases": [], "types": ["T044"], "canonical_name": "amino acid transporter activity"}
{"concept_id": "C1153036", "aliases": [], "types": ["T044"], "canonical_name": "acidic amino acid transporter activity"}
{"concept_id": "C1153038", "aliases": ["glutamate/aspartate:sodium symporter activity"], "types": ["T044"], "canonical_name": "glutamate/aspartate:sodium symporter activity", "definition": "OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in). [TC:2.A.23.1.1]"}
{"concept_id": "C1153040", "aliases": ["sodium/excitatory glutamate symporter activity", "sodium/excitatory glutamate cotransporter activity"], "types": ["T044"], "canonical_name": "glutamate:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). [TC:2.A.27.1.1]"}
{"concept_id": "C1153042", "aliases": [], "types": ["T044"], "canonical_name": "aromatic amino acid transporter activity"}
{"concept_id": "C1153046", "aliases": [], "types": ["T044"], "canonical_name": "basic amino acid transporter activity"}
{"concept_id": "C1153052", "aliases": ["branched-chain aliphatic amino acid transmembrane transporter activity", "branched-chain aliphatic amino acid transporter activity"], "types": ["T044"], "canonical_name": "branched-chain amino acid transmembrane transporter activity", "definition": "Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. [GOC:ai, GOC:bf, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153053", "aliases": [], "types": ["T044"], "canonical_name": "L-amino acid transporter activity"}
{"concept_id": "C1153059", "aliases": ["betaine/GABA:sodium symporter activity", "GABA:sodium symporter activity", "4-aminobutyrate:sodium symporter activity", "gamma-aminobutyric acid:sodium symporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in). [TC:2.A.22.3.2]", "canonical_name": "4-aminobutanoate:sodium symporter activity"}
{"concept_id": "C1153060", "aliases": [], "types": ["T044"], "canonical_name": "glycine transporter activity"}
{"concept_id": "C1153066", "aliases": [], "types": ["T044"], "canonical_name": "proline:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in). [GOC:ai]"}
{"concept_id": "C1153067", "aliases": ["sodium/proline symporter activity"], "types": ["T044"], "canonical_name": "proline:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). [TC:2.A.22.2.1]"}
{"concept_id": "C1153069", "aliases": ["threonine/serine:sodium symporter activity"], "types": ["T044"], "canonical_name": "threonine/serine:sodium symporter activity", "definition": "OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in). [TC:2.A.23.4.1]"}
{"concept_id": "C1153072", "aliases": [], "types": ["T044"], "canonical_name": "neutral amino acid transporter activity"}
{"concept_id": "C1153073", "aliases": ["sulphur amino acid transporter activity"], "types": ["T044"], "canonical_name": "sulfur amino acid transporter activity"}
{"concept_id": "C1153074", "aliases": ["S-adenosyl methionine transporter activity", "S-adenosyl-L-methionine transmembrane transporter activity", "S-adenosylmethionine permease activity", "S-adenosyl methionine permease activity", "SAM transmembrane transporter activity", "S-adenosylmethionine transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. [GOC:ai]", "canonical_name": "S-adenosylmethionine transporter activity"}
{"concept_id": "C1153075", "aliases": [], "types": ["T044"], "canonical_name": "S-methylmethionine transporter activity"}
{"concept_id": "C1153078", "aliases": [], "types": ["T044"], "canonical_name": "channel regulator activity", "definition": "Bonds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. [GOC:mah]"}
{"concept_id": "C1153079", "aliases": [], "types": ["T044"], "canonical_name": "calcium channel regulator activity", "definition": "Modulates the activity of a calcium channel. [GOC:mah]"}
{"concept_id": "C1153080", "aliases": [], "types": ["T044"], "canonical_name": "calcium channel inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of a calcium channel. [GOC:mah]"}
{"concept_id": "C1153081", "aliases": [], "types": ["T044"], "canonical_name": "channel inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of a channel. [GOC:mah]"}
{"concept_id": "C1153082", "aliases": [], "types": ["T044"], "canonical_name": "ion channel inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of an ion channel. [GOC:mah]"}
{"concept_id": "C1153083", "aliases": [], "types": ["T044"], "canonical_name": "chloride channel inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of a chloride channel. [GOC:mah]"}
{"concept_id": "C1153084", "aliases": [], "types": ["T044"], "canonical_name": "potassium channel inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of a potassium channel. [GOC:mah]"}
{"concept_id": "C1153085", "aliases": [], "types": ["T044"], "canonical_name": "sodium channel inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of a sodium channel. [GOC:mah]"}
{"concept_id": "C1153086", "aliases": [], "types": ["T044"], "canonical_name": "chloride channel regulator activity", "definition": "Binds to and modulates the activity of a chloride channel. [GOC:mah]"}
{"concept_id": "C1153087", "aliases": ["potassium channel gating activity"], "types": ["T044"], "canonical_name": "potassium channel regulator activity", "definition": "Binds to and modulates the activity of a potassium channel. [GOC:dos, GOC:mah]"}
{"concept_id": "C1153088", "aliases": [], "types": ["T044"], "canonical_name": "sodium channel regulator activity", "definition": "Binds to and modulates the activity of a sodium channel. [GOC:mah]"}
{"concept_id": "C1153089", "aliases": ["low voltage-gated potassium channel auxiliary protein activity"], "types": ["T044"], "canonical_name": "low voltage-dependent potassium channel auxiliary protein activity"}
{"concept_id": "C1153090", "aliases": [], "types": ["T044"], "canonical_name": "sodium channel auxiliary protein activity"}
{"concept_id": "C1153093", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate transporter activity"}
{"concept_id": "C1153094", "aliases": [], "types": ["T044"], "canonical_name": "disaccharide transmembrane transporter activity", "definition": "Enables the transfer of disaccharide from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153097", "aliases": ["lactose, galactose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "lactose, galactose:hydrogen symporter activity", "definition": "OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in). [TC:2.A.1.1.9]"}
{"concept_id": "C1153098", "aliases": ["lactose/glucose efflux transporter activity"], "types": ["T044"], "canonical_name": "lactose/glucose efflux transporter activity", "definition": "OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out). [TC:2.A.1.20.2]"}
{"concept_id": "C1153099", "aliases": ["lactose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "lactose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in). [TC:2.A.1.1.9, TC:2.A.1.5.1]"}
{"concept_id": "C1153101", "aliases": ["maltoporin"], "types": ["T044"], "definition": "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport]", "canonical_name": "maltose transporting porin activity"}
{"concept_id": "C1153102", "aliases": ["maltose:hydrogen symporter activity", "hydrogen/maltose transporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in). [TC:2.A.1.1.10]", "canonical_name": "maltose:proton symporter activity"}
{"concept_id": "C1153103", "aliases": [], "types": ["T044"], "canonical_name": "melibiose transmembrane transporter activity", "definition": "Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1153104", "aliases": ["melibiose permease"], "types": ["T044"], "canonical_name": "melibiose permease activity"}
{"concept_id": "C1153105", "aliases": ["sucrose permease (PTS) activity"], "types": ["T044"], "canonical_name": "sucrose transmembrane transporter activity", "definition": "Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1153106", "aliases": [], "types": ["T044"], "canonical_name": "sucrose permease activity"}
{"concept_id": "C1153107", "aliases": ["sucrose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "sucrose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in). [TC:2.A.1.5.3]"}
{"concept_id": "C1153110", "aliases": ["glucuronide transporter activity"], "types": ["T044"], "canonical_name": "glucuronoside transmembrane transporter activity", "definition": "Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153111", "aliases": [], "types": ["T044"], "canonical_name": "glucuronoside permease activity"}
{"concept_id": "C1153112", "aliases": [], "types": ["T044"], "canonical_name": "monosaccharide transmembrane transporter activity", "definition": "Enables the transfer of a monosaccharide from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153113", "aliases": [], "types": ["T044"], "canonical_name": "hexose transmembrane transporter activity", "definition": "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153116", "aliases": [], "types": ["T044"], "canonical_name": "fructose uniporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in). [TC:2.A.1.1.13]"}
{"concept_id": "C1153118", "aliases": ["fucose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "fucose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in). [TC:2.A.1.7.1]"}
{"concept_id": "C1153121", "aliases": ["galactose, glucose uniporter activity"], "types": ["T044"], "canonical_name": "galactose, glucose uniporter activity", "definition": "OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in). [TC:2.A.1.1.6]"}
{"concept_id": "C1153122", "aliases": ["galactose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "galactose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in). [TC:2.A.1.1.1, TC:2.A.1.1.9]"}
{"concept_id": "C1153123", "aliases": [], "types": ["T044"], "canonical_name": "galactose:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-]"}
{"concept_id": "C1153125", "aliases": [], "types": ["T044"], "canonical_name": "alpha-glucoside transmembrane transporter activity", "definition": "Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1153126", "aliases": ["beta-glucoside permease activity"], "types": ["T044"], "definition": "Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration. [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729]", "canonical_name": "beta-glucoside transmembrane transporter activity"}
{"concept_id": "C1153127", "aliases": [], "types": ["T044"], "canonical_name": "glucose uniporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in). [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6]"}
{"concept_id": "C1153128", "aliases": [], "types": ["T044"], "canonical_name": "glucose-6-phosphate transmembrane transporter activity", "definition": "Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153129", "aliases": ["sodium/glucose symporter activity"], "types": ["T044"], "canonical_name": "glucose:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-]"}
{"concept_id": "C1153131", "aliases": [], "types": ["T044"], "canonical_name": "hexose uniporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in). [TC:2.A.1.1.5]"}
{"concept_id": "C1153138", "aliases": [], "types": ["T044"], "canonical_name": "pentose transmembrane transporter activity", "definition": "Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153142", "aliases": ["arabinose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "arabinose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in). [TC:2.A.1.1.2]"}
{"concept_id": "C1153147", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine nucleotide-sugar transmembrane transporter activity", "definition": "Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153148", "aliases": ["CMP-sialic acid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "CMP-N-acetylneuraminate transmembrane transporter activity", "definition": "Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153149", "aliases": [], "types": ["T044"], "canonical_name": "GDP-fucose transmembrane transporter activity", "definition": "Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153150", "aliases": [], "types": ["T044"], "canonical_name": "GDP-mannose transmembrane transporter activity", "definition": "Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153151", "aliases": [], "types": ["T044"], "canonical_name": "UDP-galactose transmembrane transporter activity", "definition": "Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153152", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose transmembrane transporter activity", "definition": "Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153153", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucuronic acid transmembrane transporter activity", "definition": "Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153154", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetylgalactosamine transmembrane transporter activity", "definition": "Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153155", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetylglucosamine transmembrane transporter activity", "definition": "Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153156", "aliases": [], "types": ["T044"], "canonical_name": "UDP-xylose transmembrane transporter activity", "definition": "Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1153158", "aliases": [], "types": ["T044"], "canonical_name": "endosomal oligosaccharide transporter", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153159", "aliases": [], "types": ["T044"], "canonical_name": "oligosaccharide transporting porin activity", "definition": "Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport]"}
{"concept_id": "C1153160", "aliases": [], "types": ["T044"], "canonical_name": "raffinose transmembrane transporter activity", "definition": "Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1153161", "aliases": ["raffinose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "raffinose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in). [TC:2.A.1.5.2]"}
{"concept_id": "C1153162", "aliases": [], "types": ["T044"], "canonical_name": "sialic acid transmembrane transporter activity", "definition": "Enables the transfer of sialic acid from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153163", "aliases": [], "types": ["T044"], "canonical_name": "sialic acid permease activity"}
{"concept_id": "C1153164", "aliases": ["sugar transporter"], "types": ["T044"], "canonical_name": "sugar porter activity"}
{"concept_id": "C1153165", "aliases": ["2-keto-3-deoxygluconate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "2-keto-3-deoxygluconate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in). [TC:2.A.10.1.1]"}
{"concept_id": "C1153166", "aliases": ["carbohydrate:cation symporter activity", "cation/sugar symporter activity", "cation:sugar symporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). [GOC:ai]", "canonical_name": "sugar:cation symporter activity"}
{"concept_id": "C1153167", "aliases": ["hydrogen:sugar symporter activity", "sugar:proton symporter activity", "sugar:hydrogen ion symporter activity", "carbohydrate:proton symporter activity", "sugar:hydrogen symporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). [TC:2.A.1.1]", "canonical_name": "proton:sugar symporter activity"}
{"concept_id": "C1153169", "aliases": ["high-affinity hydrogen:glucose symporter activity", "high-affinity hydrogen/glucose transporter activity", "high-affinity hydrogen:glucose transporter activity"], "types": ["T044"], "canonical_name": "high-affinity glucose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport]"}
{"concept_id": "C1153172", "aliases": ["low-affinity hydrogen/glucose transporter activity", "low-affinity hydrogen:glucose symporter activity", "low-affinity hydrogen:glucose transporter activity"], "types": ["T044"], "canonical_name": "low-affinity glucose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport]"}
{"concept_id": "C1153174", "aliases": ["rhamnose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "rhamnose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in). [TC:2.A.7.6]"}
{"concept_id": "C1153175", "aliases": ["general alpha-glucoside:hydrogen symporter activity", "alpha-glucoside:hydrogen symporter activity", "general alpha-glucoside:proton symporter activity"], "types": ["T044"], "canonical_name": "alpha-glucoside:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose. [TC:2.A.1.1.11]"}
{"concept_id": "C1153176", "aliases": [], "types": ["T044"], "canonical_name": "glucose 6-phosphate:phosphate antiporter activity"}
{"concept_id": "C1153177", "aliases": [], "types": ["T044"], "canonical_name": "glycerol-phosphate:inorganic phosphate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out). [TC:2.A.1.4.3]"}
{"concept_id": "C1153178", "aliases": [], "types": ["T044"], "canonical_name": "glycoside-pentoside-hexuronide:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+. [TC:2.A.2.-.-]"}
{"concept_id": "C1153179", "aliases": [], "types": ["T044"], "canonical_name": "hexose-phosphate:inorganic phosphate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out). [TC:2.A.1.4.1]"}
{"concept_id": "C1153180", "aliases": ["hexose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "hexose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in). [TC:2.A.1.-.-]"}
{"concept_id": "C1153181", "aliases": [], "types": ["T044"], "canonical_name": "hexuronate porter activity"}
{"concept_id": "C1153182", "aliases": ["L-idonate/D-gluconate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "L-idonate/D-gluconate:hydrogen symporter activity", "definition": "OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in). [TC:2.A.8.1.2]"}
{"concept_id": "C1153183", "aliases": ["lactate:hydrogen porter activity", "lactate:hydrogen symporter activity", "lactate:proton porter activity"], "types": ["T044"], "canonical_name": "lactate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in). [TC:2.A.14.1.1]"}
{"concept_id": "C1153186", "aliases": [], "types": ["T044"], "canonical_name": "beta-glucan transmembrane transporter activity", "definition": "Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153187", "aliases": ["capsule polysaccharide transporter activity"], "types": ["T044"], "canonical_name": "capsular polysaccharide transmembrane transporter activity"}
{"concept_id": "C1153188", "aliases": ["LPS transmembrane transporter activity"], "types": ["T044"], "canonical_name": "lipopolysaccharide transmembrane transporter activity", "definition": "Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153190", "aliases": [], "types": ["T044"], "canonical_name": "teichoic acid transmembrane transporter activity"}
{"concept_id": "C1153191", "aliases": ["sialate/cation symporter activity", "cation:sialate symporter activity", "cation/sialate symporter activity"], "types": ["T044"], "canonical_name": "sialate:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in). [TC:2.A.1.14.10]"}
{"concept_id": "C1153195", "aliases": [], "types": ["T044"], "canonical_name": "ion-gradient-driven energizer activity"}
{"concept_id": "C1153196", "aliases": [], "types": ["T044"], "canonical_name": "energizer of outer membrane receptor-mediated transport activity"}
{"concept_id": "C1153197", "aliases": ["porter activity", "coupled carrier", "secondary carrier-type facilitators", "electrochemical potential-driven transporter activity", "secondary active transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]", "canonical_name": "porters"}
{"concept_id": "C1153198", "aliases": ["countertransporter activity", "antiporter activity", "solute:solute antiporter activity", "porter", "exchange transporter activity"], "types": ["T043"], "definition": "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]", "canonical_name": "antiport"}
{"concept_id": "C1153199", "aliases": ["anion exchanger activity"], "types": ["T044"], "canonical_name": "anion:anion antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). [GOC:ai, GOC:mtg_transport]"}
{"concept_id": "C1153200", "aliases": [], "types": ["T044"], "canonical_name": "bicarbonate:chloride antiporter"}
{"concept_id": "C1153202", "aliases": [], "types": ["T044"], "canonical_name": "inorganic anion exchanger activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). [GOC:mah]"}
{"concept_id": "C1153203", "aliases": [], "types": ["T044"], "canonical_name": "citrate:succinate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out). [TC:2.A.47.3.2]"}
{"concept_id": "C1153204", "aliases": ["sulphate:bicarbonate antiporter activity"], "types": ["T044"], "canonical_name": "sulfate:bicarbonate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out). [TC:2.A.53.2.2]"}
{"concept_id": "C1153205", "aliases": [], "types": ["T044"], "canonical_name": "tartrate:succinate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out). [TC:2.A.47.3.3]"}
{"concept_id": "C1153206", "aliases": [], "types": ["T044"], "canonical_name": "cation:cation antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). [GOC:ai]"}
{"concept_id": "C1153207", "aliases": ["potassium:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "potassium:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). [TC:2.A.37.-.-]"}
{"concept_id": "C1153208", "aliases": [], "types": ["T044"], "canonical_name": "pH-dependent sodium:hydrogen antiporter activity"}
{"concept_id": "C1153211", "aliases": ["dicarboxylate (succinate/fumarate/malate) antiporter activity"], "types": ["T044"], "canonical_name": "dicarboxylate (succinate/fumarate/malate) antiporter activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153212", "aliases": [], "types": ["T044"], "canonical_name": "dicarboxylate:inorganic phosphate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out). [TC:2.A.29.2.3]"}
{"concept_id": "C1153213", "aliases": ["monovalent cation:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "monovalent cation:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). [GOC:ai]"}
{"concept_id": "C1153214", "aliases": ["2-oxoglutarate/malate carrier protein"], "types": ["T044"], "canonical_name": "oxoglutarate:malate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out). [TC:2.A.29.2.1]"}
{"concept_id": "C1153216", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA:CoA antiporter activity", "definition": "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out). [TC:2.A.1.25.1]"}
{"concept_id": "C1153217", "aliases": [], "types": ["T044"], "canonical_name": "solute:cation antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). [GOC:ai]"}
{"concept_id": "C1153218", "aliases": [], "types": ["T044"], "canonical_name": "calcium:cation antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). [TC:2.A.19.-.-]"}
{"concept_id": "C1153219", "aliases": [], "types": ["T044"], "canonical_name": "calcium, potassium:sodium antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). [TC:2.A.19.4.1]"}
{"concept_id": "C1153220", "aliases": ["calcium:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "calcium:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in). [TC:2.A.19.2.-]"}
{"concept_id": "C1153221", "aliases": ["sodium/calcium exchanger"], "types": ["T044"], "canonical_name": "calcium:sodium antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). [GOC:curators, PMID:16371597]"}
{"concept_id": "C1153222", "aliases": ["solute:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "solute:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). [GOC:ai]"}
{"concept_id": "C1153224", "aliases": ["amiloride:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "amiloride:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out). [TC:2.A.1.2.1]"}
{"concept_id": "C1153225", "aliases": ["azole:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "azole:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances. [GOC:ai, ISBN:3527307206, Wikipedia:Azole]"}
{"concept_id": "C1153226", "aliases": ["aminotriazole:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "aminotriazole:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out). [TC:2.A.1.3.1]"}
{"concept_id": "C1153227", "aliases": ["bicyclomycin/sulfathiazole:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "bicyclomycin/sulfathiazole:hydrogen antiporter activity", "definition": "OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in). [TC:2.A.1.2.7]"}
{"concept_id": "C1153228", "aliases": ["fluconazole:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "fluconazole:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out). [TC:2.A.1.2.17]"}
{"concept_id": "C1153229", "aliases": ["benomyl:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "benomyl:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out). [TC:2.A.1.2.6]"}
{"concept_id": "C1153230", "aliases": ["carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153231", "aliases": ["cycloheximide:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "cycloheximide:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out). [TC:2.A.1.2.2]"}
{"concept_id": "C1153233", "aliases": ["tetracycline:hydrogen antiporter activity", "tetracyclin:hydrogen antiporter activity", "tetracyclin:proton antiporter activity"], "types": ["T044"], "canonical_name": "tetracycline:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). [TC:2.A.1.2.4]"}
{"concept_id": "C1153234", "aliases": [], "types": ["T044"], "canonical_name": "organophosphate:inorganic phosphate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out). [TC:2.A.1.4.-]"}
{"concept_id": "C1153235", "aliases": [], "types": ["T044"], "canonical_name": "succinate:fumarate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out). [TC:2.A.29.13.1]"}
{"concept_id": "C1153238", "aliases": ["ATP/ADP exchanger", "ADP/ATP translocase", "ADP/ATP carrier protein", "adenine nucleotide translocase", "ATP:ADP antiporter activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). [TC:2.A.29.1.1]", "canonical_name": "ATP/ADP exchange"}
{"concept_id": "C1153239", "aliases": [], "types": ["T044"], "canonical_name": "bilirubin porter activity"}
{"concept_id": "C1153240", "aliases": ["carnitine:acyl carnitine carrier activity", "fatty acyl carnitine carrier", "carnitine/acyl carnitine carrier activity"], "types": ["T044"], "canonical_name": "carnitine:acyl carnitine antiporter activity", "definition": "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial). [PMID:9032458]"}
{"concept_id": "C1153241", "aliases": [], "types": ["T044"], "canonical_name": "cyanate porter activity"}
{"concept_id": "C1153246", "aliases": ["formate efflux permease activity"], "types": ["T044"], "canonical_name": "formate efflux transmembrane transporter activity", "definition": "Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153248", "aliases": [], "types": ["T044"], "canonical_name": "glutathione-regulated potassium exporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state. [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2]"}
{"concept_id": "C1153250", "aliases": [], "types": ["T044"], "canonical_name": "cadmium ion transmembrane transporter activity", "definition": "Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other. [GOC:dgf]"}
{"concept_id": "C1153251", "aliases": ["zinc, cadmium uptake permease activity"], "types": ["T044"], "canonical_name": "zinc, cadmium uptake permease activity", "definition": "OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport. [TC:2.A.4.2.2]"}
{"concept_id": "C1153253", "aliases": ["cobalt, zinc uptake permease activity"], "types": ["T044"], "canonical_name": "cobalt, zinc uptake permease activity", "definition": "OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport. [TC:2.A.4.2.1]"}
{"concept_id": "C1153254", "aliases": ["zinc efflux transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane. [GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "zinc efflux permease activity"}
{"concept_id": "C1153255", "aliases": [], "types": ["T044"], "canonical_name": "cobalt ion transmembrane transporter activity", "definition": "Enables the transfer of cobalt (Co) ions from one side of a membrane to the other. [GOC:dgf]"}
{"concept_id": "C1153256", "aliases": [], "types": ["T044"], "canonical_name": "copper ion transmembrane transporter activity", "definition": "Enables the transfer of copper (Cu) ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153260", "aliases": [], "types": ["T044"], "canonical_name": "plasma membrane copper transporter", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153261", "aliases": ["heavy metal ion:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "heavy metal ion:hydrogen symporter activity", "definition": "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+. [TC:2.A.55.2.1, TC:2.A.55.2.2]"}
{"concept_id": "C1153262", "aliases": ["high affinity metal ion uptake transporter activity"], "types": ["T044"], "canonical_name": "high affinity metal ion uptake transporter activity", "definition": "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+. [TC:2.A.55.1.1]"}
{"concept_id": "C1153264", "aliases": [], "types": ["T044"], "canonical_name": "ferric triacetylfusarinine C transmembrane transporter activity", "definition": "Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153265", "aliases": ["ferric triacetylfusarinine C:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "ferric triacetylfusarinine C:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in). [TC:2.A.1.16.3]"}
{"concept_id": "C1153267", "aliases": ["iron channel activity", "iron cation channel activity", "transmembrane iron permease activity", "transmembrane iron ion permease activity", "iron transporter activity"], "types": ["T044"], "canonical_name": "iron ion transmembrane transporter activity", "definition": "Enables the transfer of iron (Fe) ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153269", "aliases": [], "types": ["T044"], "canonical_name": "high affinity ferric uptake transmembrane transporter activity"}
{"concept_id": "C1153274", "aliases": ["siderophore-iron transporter activity", "iron-siderophore transporter activity"], "types": ["T044"], "canonical_name": "siderophore transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). [TC:2.A.1.16.-]"}
{"concept_id": "C1153275", "aliases": [], "types": ["T044"], "canonical_name": "arsenite porter activity"}
{"concept_id": "C1153277", "aliases": ["ferric enterobactin:hydrogen symporter activity", "ferric-enterobactin:proton symporter activity"], "types": ["T044"], "canonical_name": "ferric enterobactin:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in). [TC:2.A.1.16.2]"}
{"concept_id": "C1153281", "aliases": ["zinc, iron permease activity"], "types": ["T044"], "canonical_name": "zinc, iron permease activity", "definition": "OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force. [TC:2.A.5.-.-]"}
{"concept_id": "C1153282", "aliases": ["high affinity zinc uptake transmembrane transporter activity", "high-affinity zinc uptake transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity zinc transmembrane transporter activity", "definition": "Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [TC:2.A.5.1.1]"}
{"concept_id": "C1153283", "aliases": [], "types": ["T044"], "canonical_name": "lead ion transmembrane transporter activity", "definition": "Enables the transfer of lead (Pb) ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153284", "aliases": ["low affinity metal ion uptake transporter activity"], "types": ["T044"], "canonical_name": "low affinity metal ion uptake transporter activity", "definition": "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+. [TC:2.A.55.1.2]"}
{"concept_id": "C1153285", "aliases": [], "types": ["T044"], "canonical_name": "manganese ion transmembrane transporter activity", "definition": "Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. [GOC:dgf]"}
{"concept_id": "C1153287", "aliases": [], "types": ["T044"], "canonical_name": "mercury ion transmembrane transporter activity", "definition": "Enables the transfer of mercury (Hg) ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153288", "aliases": ["molybdate transporter activity"], "types": ["T044"], "canonical_name": "molybdate ion transmembrane transporter activity", "definition": "Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. [ISBN:0198506732]"}
{"concept_id": "C1153289", "aliases": [], "types": ["T044"], "canonical_name": "nickel cation transmembrane transporter activity", "definition": "Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153291", "aliases": ["tellurite-resistance uptake permease activity", "tellurite-resistance uptake transmembrane transporter activity"], "types": ["T044"], "canonical_name": "tellurite uptake transmembrane transporter activity"}
{"concept_id": "C1153292", "aliases": [], "types": ["T044"], "canonical_name": "vanadium ion transmembrane transporter activity", "definition": "Enables the transfer of vanadium (V) ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153293", "aliases": [], "types": ["T044"], "canonical_name": "zinc ion transmembrane transporter activity", "definition": "Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. [GOC:dgf]"}
{"concept_id": "C1153294", "aliases": [], "types": ["T044"], "canonical_name": "low-affinity zinc ion transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153296", "aliases": [], "types": ["T044"], "canonical_name": "inorganic phosphate transmembrane transporter activity", "definition": "Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]"}
{"concept_id": "C1153297", "aliases": ["inorganic solute uptake transmembrane transporter activity", "inorganic uptake permease activity"], "types": ["T044"], "canonical_name": "inorganic molecular entity transmembrane transporter activity", "definition": "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153300", "aliases": ["phosphate ion carrier activity", "phosphate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "phosphate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in). [TC:2.A.1.9.-]"}
{"concept_id": "C1153302", "aliases": ["sodium/phosphate symporter activity"], "types": ["T044"], "canonical_name": "sodium:phosphate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). [GOC:ai]"}
{"concept_id": "C1153303", "aliases": ["high affinity inorganic phosphate:sodium symporter activity"], "types": ["T044"], "canonical_name": "high-affinity inorganic phosphate:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [TC:2.A.20.2.2]"}
{"concept_id": "C1153304", "aliases": [], "types": ["T044"], "canonical_name": "sodium:inorganic phosphate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in). [TC:2.A.1.14.6]"}
{"concept_id": "C1153306", "aliases": [], "types": ["T044"], "canonical_name": "methotrexate transporter activity"}
{"concept_id": "C1153308", "aliases": ["nitrite extrusion permease activity"], "types": ["T044"], "canonical_name": "nitrite efflux transmembrane transporter activity", "definition": "Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153309", "aliases": ["nitrite uptake permease activity"], "types": ["T044"], "canonical_name": "high-affinity secondary active nitrite transmembrane transporter activity", "definition": "Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153310", "aliases": ["nitrite/nitrate porter activity"], "types": ["T044"], "canonical_name": "nitrite/nitrate porter activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153311", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside permease activity"}
{"concept_id": "C1153312", "aliases": [], "types": ["T044"], "canonical_name": "xanthosine permease activity"}
{"concept_id": "C1153313", "aliases": [], "types": ["T044"], "canonical_name": "oligopeptide porter activity"}
{"concept_id": "C1153314", "aliases": [], "types": ["T044"], "canonical_name": "organic cation porter activity"}
{"concept_id": "C1153315", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxyphenyl propionate porter activity"}
{"concept_id": "C1153316", "aliases": ["hydrogen:acetate symporter activity", "acetate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "acetate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in). [TC:2.A.44.4.1]"}
{"concept_id": "C1153317", "aliases": ["alpha-ketoglutarate:hydrogen symporter activity", "2-oxoglutarate:hydrogen symporter activity", "2-oxoglutarate:proton symporter activity"], "types": ["T044"], "canonical_name": "alpha-ketoglutarate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in). [TC:2.A.1.6.2]"}
{"concept_id": "C1153318", "aliases": ["citrate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "citrate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in). [TC:2.A.1.6.1]"}
{"concept_id": "C1153319", "aliases": [], "types": ["T044"], "canonical_name": "dicarboxylic acid permease activity"}
{"concept_id": "C1153320", "aliases": [], "types": ["T044"], "canonical_name": "high affinity sodium:dicarboxylate cotransporter activity"}
{"concept_id": "C1153321", "aliases": [], "types": ["T044"], "canonical_name": "low affinity sodium:dicarboxylate cotransporter activity"}
{"concept_id": "C1153322", "aliases": ["malate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "malate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in). [TC:2.A.16.2.1]"}
{"concept_id": "C1153323", "aliases": [], "types": ["T044"], "canonical_name": "monocarboxylate porter activity"}
{"concept_id": "C1153324", "aliases": ["monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity"], "types": ["T044"], "canonical_name": "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153325", "aliases": [], "types": ["T044"], "canonical_name": "oxaloacetate carrier activity"}
{"concept_id": "C1153326", "aliases": [], "types": ["T044"], "canonical_name": "phenyl propionate permease activity"}
{"concept_id": "C1153328", "aliases": ["sodium:dicarboxylate/tricarboxylate symporter activity"], "types": ["T044"], "canonical_name": "sodium:dicarboxylate/tricarboxylate symporter activity", "definition": "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in). [TC:2.A.47.1.5]"}
{"concept_id": "C1153329", "aliases": ["shikimate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "shikimate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in). [TC:2.A.1.6.6]"}
{"concept_id": "C1153330", "aliases": ["tricarboxylate carrier activity"], "types": ["T044"], "definition": "Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "tricarboxylate secondary active transmembrane transporter activity"}
{"concept_id": "C1153331", "aliases": [], "types": ["T044"], "canonical_name": "peptide-acetyl-CoA transporter activity"}
{"concept_id": "C1153333", "aliases": ["prostaglandin/thromboxane transporter activity"], "types": ["T044"], "canonical_name": "prostaglandin/thromboxane transporter activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153334", "aliases": ["proton-dependent oligopeptide transporter activity"], "types": ["T044"], "canonical_name": "proton-dependent oligopeptide secondary active transmembrane transporter activity", "definition": "Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. [GOC:mtg_transport, OMIM:600544]"}
{"concept_id": "C1153335", "aliases": ["high-affinity oligopeptide transporter activity", "high affinity oligopeptide transporter activity"], "types": ["T044"], "canonical_name": "high-affinity oligopeptide transmembrane transporter activity", "definition": "Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [GOC:mtg_transport]"}
{"concept_id": "C1153336", "aliases": ["nitrate(chlorate):hydrogen symporter activity", "nitrate(chlorate):proton symporter activity", "nitrate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "nitrate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in). [GOC:mah, PMID:10066586, PMID:1990981]"}
{"concept_id": "C1153337", "aliases": ["peptide:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "peptide:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement. [GOC:mtg_transport, TC:2.A.17.-.-]"}
{"concept_id": "C1153338", "aliases": [], "types": ["T044"], "canonical_name": "reduced folate carrier activity"}
{"concept_id": "C1153341", "aliases": ["sulfate porter activity", "secondary active sulphate transmembrane transporter activity", "sulphate porter activity"], "types": ["T044"], "definition": "Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]", "canonical_name": "secondary active sulfate transmembrane transporter activity"}
{"concept_id": "C1153342", "aliases": ["high affinity sulfate transmembrane transporter activity", "high affinity sulfate permease activity", "high affinity sulphate permease activity"], "types": ["T044"], "canonical_name": "high-affinity sulfate transmembrane transporter activity", "definition": "Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations. [GOC:mtg_transport]"}
{"concept_id": "C1153343", "aliases": ["sodium:sulphate symporter activity", "sodium:sulfate cotransporter activity"], "types": ["T044"], "canonical_name": "sodium:sulfate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in). [TC:2.A.47.1.2]"}
{"concept_id": "C1153344", "aliases": ["sulfate/hydrogen symporter activity", "sulphate:hydrogen symporter activity", "sulfate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "sulfate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). [TC:2.A.53.-.-]"}
{"concept_id": "C1153345", "aliases": ["high affinity sulfate:hydrogen symporter activity", "high affinity sulphate:hydrogen symporter activity", "high affinity sulfate:proton symporter activity"], "types": ["T044"], "canonical_name": "high-affinity sulfate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mah]"}
{"concept_id": "C1153346", "aliases": ["low affinity sulfate:proton symporter activity", "low affinity sulfate:hydrogen symporter activity", "low affinity sulphate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "low-affinity sulfate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [GOC:mah, PMID:7568135]"}
{"concept_id": "C1153347", "aliases": ["cotransporter activity", "symporter activity", "porter activity"], "types": ["T043"], "definition": "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]", "canonical_name": "symport"}
{"concept_id": "C1153348", "aliases": [], "types": ["T044"], "canonical_name": "anion:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). [TC:2.A.1.14.-]"}
{"concept_id": "C1153349", "aliases": ["auxin:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "auxin:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in). [PMID:8688077]"}
{"concept_id": "C1153350", "aliases": ["cation:chloride cotransporter activity"], "types": ["T044"], "canonical_name": "cation:chloride symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). [PMID:31747317]"}
{"concept_id": "C1153351", "aliases": [], "types": ["T044"], "canonical_name": "potassium:chloride symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). [TC:2.A.30.1.5]"}
{"concept_id": "C1153352", "aliases": [], "types": ["T044"], "canonical_name": "sodium:chloride symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in). [TC:2.A.30.4.-]"}
{"concept_id": "C1153353", "aliases": ["sodium/potassium/chloride symporter activity"], "types": ["T044"], "canonical_name": "sodium:potassium:chloride symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in). [TC:2.A.30.1.1]"}
{"concept_id": "C1153354", "aliases": [], "types": ["T044"], "canonical_name": "potassium:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in). [TC:2.A.38.3.1]"}
{"concept_id": "C1153355", "aliases": ["sodium:bicarbonate cotransporter activity", "sodium/bicarbonate cotransporter activity"], "types": ["T044"], "canonical_name": "sodium:bicarbonate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). [TC:2.A.31.2.1]"}
{"concept_id": "C1153356", "aliases": [], "types": ["T044"], "canonical_name": "solute:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). [GOC:ai]"}
{"concept_id": "C1153357", "aliases": [], "types": ["T044"], "canonical_name": "sodium-dependent L-ascorbic acid transporter"}
{"concept_id": "C1153358", "aliases": [], "types": ["T044"], "canonical_name": "nucleobase:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in). [GOC:ai]"}
{"concept_id": "C1153359", "aliases": [], "types": ["T045"], "canonical_name": "allantoin permease activity"}
{"concept_id": "C1153360", "aliases": [], "types": ["T044"], "canonical_name": "cytosine permease activity"}
{"concept_id": "C1153362", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside (uridine) permease activity"}
{"concept_id": "C1153363", "aliases": [], "types": ["T044"], "canonical_name": "uracil permease activity"}
{"concept_id": "C1153364", "aliases": ["uracil/uridine permease activity"], "types": ["T044"], "canonical_name": "uracil/uridine permease activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153365", "aliases": ["nucleoside-sodium cotransporter activity", "nucleoside:sodium symporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). [GOC:ai]", "canonical_name": "sodium-dependent nucleoside transporter activity"}
{"concept_id": "C1153366", "aliases": [], "types": ["T044"], "canonical_name": "purine-specific nucleoside:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in). [TC:2.A.41.2.1]"}
{"concept_id": "C1153367", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine- and adenine-specific:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in). [TC:2.A.41.2.3]"}
{"concept_id": "C1153368", "aliases": ["solute:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "solute:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). [GOC:ai]"}
{"concept_id": "C1153369", "aliases": ["nucleoside:hydrogen symporter activity", "nucleoside:hydrogen ion symporter activity"], "types": ["T044"], "canonical_name": "nucleoside:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in). [TC:2.A.1.10.1, TC:2.A.41.1.1]"}
{"concept_id": "C1153370", "aliases": ["potassium:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "potassium:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in). [TC:2.A.38.-.-]"}
{"concept_id": "C1153371", "aliases": ["quaternary ammonium group:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "quaternary ammonium group:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in). [GOC:ai]"}
{"concept_id": "C1153372", "aliases": ["glycine betaine:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "glycine betaine:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in). [TC:2.A.15.1.1]"}
{"concept_id": "C1153373", "aliases": [], "types": ["T044"], "canonical_name": "solute:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). [GOC:ai]"}
{"concept_id": "C1153374", "aliases": ["monovalent anion:sodium symporter activity"], "types": ["T044"], "canonical_name": "anion:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in). [TC:2.A.21.5.-]"}
{"concept_id": "C1153375", "aliases": ["sodium/iodide symporter activity"], "types": ["T044"], "canonical_name": "sodium:iodide symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in). [TC:2.A.21.5.1]"}
{"concept_id": "C1153376", "aliases": ["myo-inositol-sodium cotransporter activity"], "types": ["T044"], "canonical_name": "myo-inositol:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in). [TC:2.A.21.4.-]"}
{"concept_id": "C1153378", "aliases": [], "types": ["T044"], "canonical_name": "creatine:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). [TC:2.A.22.3.4]"}
{"concept_id": "C1153379", "aliases": ["serotonin transmembrane transporter activity", "sodium/serotonin symporter activity", "serotonin:sodium:chloride symporter activity"], "types": ["T044"], "canonical_name": "serotonin:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in). [PMID:21752877, PMID:22519513, TC:2.A.22.1.1]"}
{"concept_id": "C1153380", "aliases": [], "types": ["T044"], "canonical_name": "organic acid:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). [TC:2.A.28.1.1]"}
{"concept_id": "C1153381", "aliases": ["sodium/bile acid symporter activity"], "types": ["T044"], "canonical_name": "bile acid:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). [TC:2.A.28.-.-]"}
{"concept_id": "C1153382", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in). [TC:2.A.21.1.1]"}
{"concept_id": "C1153388", "aliases": [], "types": ["T044"], "canonical_name": "uncoupling protein activity"}
{"concept_id": "C1153389", "aliases": ["single-species transporter activity", "facilitated diffusion carrier"], "types": ["T044"], "canonical_name": "uniporter activity", "definition": "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]"}
{"concept_id": "C1153390", "aliases": [], "types": ["T044"], "canonical_name": "electron transporter activity", "definition": "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells. [GOC:ai]"}
{"concept_id": "C1153399", "aliases": [], "types": ["T044"], "canonical_name": "oxidative phosphorylation uncoupler activity", "definition": "Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis. [PMID:15738989, PMID:16179945]"}
{"concept_id": "C1153401", "aliases": [], "types": ["T044"], "canonical_name": "decarboxylation-driven active transmembrane transporter activity", "definition": "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-]"}
{"concept_id": "C1153402", "aliases": ["light-driven pumps", "Light absorption-driven transporters"], "types": ["T044"], "canonical_name": "light-driven active transmembrane transporter activity", "definition": "Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-]"}
{"concept_id": "C1153403", "aliases": ["Methyltransfer-driven transporters"], "types": ["T044"], "canonical_name": "methyl transfer-driven active transmembrane transporter activity", "definition": "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-]"}
{"concept_id": "C1153404", "aliases": ["oxidoreduction-driven transporter"], "types": ["T044"], "canonical_name": "oxidoreduction-driven active transmembrane transporter activity", "definition": "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]"}
{"concept_id": "C1153405", "aliases": [], "types": ["T044"], "canonical_name": "P-P-bond-hydrolysis-driven transmembrane transporter activity"}
{"concept_id": "C1153406", "aliases": ["ATPase-coupled protein transmembrane transporter activity", "protein translocase activity", "protein-transporting ATPase activity", "P-P-bond-hydrolysis-driven protein transmembrane transporter activity", "protein-transmembrane transporting ATPase activity"], "types": ["T044"], "canonical_name": "protein-transporting ATPase activity", "definition": "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153410", "aliases": ["nonselective channel activity", "channel/pore class transporter activity"], "types": ["T044"], "canonical_name": "channel activity", "definition": "Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153411", "aliases": [], "types": ["T044"], "canonical_name": "alpha-type channel activity"}
{"concept_id": "C1153413", "aliases": ["connexon channel activity"], "types": ["T044"], "definition": "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction. [GOC:dgh]", "canonical_name": "gap junction hemi-channel activity"}
{"concept_id": "C1153414", "aliases": ["innexin channel activity"], "types": ["T044"], "canonical_name": "gap junction channel activity", "definition": "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153415", "aliases": [], "types": ["T044"], "definition": "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "canonical_name": "ion channel activity"}
{"concept_id": "C1153416", "aliases": ["amine/amide/polyamine channel activity"], "types": ["T044"], "canonical_name": "amine/amide/polyamine channel activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153417", "aliases": [], "types": ["T044"], "canonical_name": "methylammonium channel activity", "definition": "Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2. [GOC:mtg_transport, GOC:pr]"}
{"concept_id": "C1153418", "aliases": [], "types": ["T044"], "canonical_name": "urea channel activity", "definition": "Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport]"}
{"concept_id": "C1153419", "aliases": [], "types": ["T044"], "canonical_name": "anion channel activity", "definition": "Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]"}
{"concept_id": "C1153420", "aliases": [], "types": ["T044"], "definition": "Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "canonical_name": "chloride channel activity"}
{"concept_id": "C1153422", "aliases": ["glycine-inhibited chloride channel activity", "extracellular-glycine-gated chloride channel activity"], "types": ["T044"], "canonical_name": "extracellularly glycine-gated chloride channel activity", "definition": "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153423", "aliases": [], "types": ["T044"], "canonical_name": "histamine-gated chloride channel activity", "definition": "Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153424", "aliases": [], "types": ["T044"], "canonical_name": "intracellular calcium activated chloride channel activity", "definition": "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport]"}
{"concept_id": "C1153425", "aliases": ["voltage-dependent chloride channel activity", "voltage gated chloride channel activity"], "types": ["T044"], "canonical_name": "voltage-gated chloride channel activity", "definition": "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153426", "aliases": ["organellar voltage gated chloride channel activity", "organellar voltage-dependent chloride channel activity"], "types": ["T044"], "canonical_name": "organellar voltage-gated chloride channel activity", "definition": "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153428", "aliases": ["voltage-dependent ion-selective channel activity"], "types": ["T044"], "canonical_name": "voltage-gated ion-selective channel activity"}
{"concept_id": "C1153429", "aliases": [], "types": ["T044"], "canonical_name": "volume-sensitive anion channel activity", "definition": "Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C1153430", "aliases": ["cation diffusion facilitator activity"], "types": ["T044"], "canonical_name": "cation channel activity", "definition": "Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]"}
{"concept_id": "C1153433", "aliases": [], "types": ["T044"], "definition": "Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "canonical_name": "calcium channel activity"}
{"concept_id": "C1153434", "aliases": [], "types": ["T044"], "canonical_name": "calcium-release channel activity", "definition": "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]"}
{"concept_id": "C1153435", "aliases": ["InsP3 receptor", "inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity", "IP3 receptor activity"], "types": ["T044"], "definition": "Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts. [GOC:mah, GOC:signaling, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor]", "canonical_name": "inositol-1,4,5-trisphosphate receptor activity"}
{"concept_id": "C1153436", "aliases": [], "types": ["T044"], "canonical_name": "intracellular ligand-gated calcium channel activity"}
{"concept_id": "C1153437", "aliases": [], "types": ["T044"], "definition": "Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. [GOC:dph, GOC:tb]", "canonical_name": "ryanodine-sensitive calcium-release channel activity"}
{"concept_id": "C1153438", "aliases": [], "types": ["T044"], "canonical_name": "store-operated calcium channel activity", "definition": "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710]"}
{"concept_id": "C1153439", "aliases": [], "types": ["T044"], "canonical_name": "stretch-activated, cation-selective, calcium channel activity", "definition": "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching. [GOC:mtg_transport]"}
{"concept_id": "C1153440", "aliases": ["depolarization-activated voltage gated calcium channel activity", "voltage gated calcium channel activity", "voltage-dependent calcium channel activity", "depolarization-activated voltage-gated calcium channel activity", "voltage-sensitive calcium channel", "depolarization-activated voltage-gated calcium channel", "voltage-gated calcium ion channel activity"], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity", "definition": "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]"}
{"concept_id": "C1153441", "aliases": [], "types": ["T044"], "canonical_name": "dihydropyridine-sensitive calcium channel activity"}
{"concept_id": "C1153442", "aliases": ["high voltage gated calcium channel activity", "high voltage-dependent calcium channel activity"], "types": ["T044"], "canonical_name": "high voltage-gated calcium channel activity", "definition": "Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]"}
{"concept_id": "C1153443", "aliases": ["light-activated voltage gated calcium channel activity", "light-activated voltage-dependent calcium channel activity"], "types": ["T044"], "canonical_name": "light-activated voltage-gated calcium channel activity", "definition": "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport]"}
{"concept_id": "C1153444", "aliases": ["T-type calcium channel", "low voltage-gated calcium channel activity", "low voltage-dependent calcium channel activity"], "types": ["T044"], "definition": "Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]", "canonical_name": "low voltage gated calcium channel activity"}
{"concept_id": "C1153445", "aliases": ["hydrogen ion channel activity"], "types": ["T044"], "canonical_name": "proton channel activity", "definition": "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]"}
{"concept_id": "C1153446", "aliases": [], "types": ["T044"], "canonical_name": "intracellular cyclic nucleotide activated cation channel activity", "definition": "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]"}
{"concept_id": "C1153447", "aliases": ["intracellular cAMP activated cation channel activity", "intracellular 3',5' cAMP activated cation channel activity", "intracellular 3',5'-cAMP activated cation channel activity", "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity", "intracellular cyclic AMP activated cation channel activity"], "types": ["T044"], "canonical_name": "intracellular cAMP-activated cation channel activity", "definition": "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]"}
{"concept_id": "C1153448", "aliases": ["intracellular cGMP activated cation channel activity"], "types": ["T044"], "canonical_name": "intracellular cGMP-activated cation channel activity", "definition": "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]"}
{"concept_id": "C1153450", "aliases": [], "types": ["T044"], "definition": "Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "canonical_name": "potassium channel activity"}
{"concept_id": "C1153451", "aliases": [], "types": ["T044"], "definition": "Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. [GOC:dph, GOC:mtg_transport]", "canonical_name": "calcium-activated potassium channel activity"}
{"concept_id": "C1153452", "aliases": ["small conductance KCa channels", "SK KCa channels", "SK calcium-activated potassium channel activity"], "types": ["T044"], "canonical_name": "small conductance calcium-activated potassium channel activity", "definition": "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, OMIM:602754]"}
{"concept_id": "C1153453", "aliases": [], "types": ["T044"], "canonical_name": "intracellular sodium activated potassium channel activity", "definition": "Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification. [GOC:mtg_transport, PMID:12628167]"}
{"concept_id": "C1153454", "aliases": ["voltage-gated potassium ion channel activity", "voltage-sensitive potassium channel", "voltage-dependent potassium channel activity", "voltage gated potassium channel activity"], "types": ["T044"], "definition": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "voltage-gated potassium channel activity"}
{"concept_id": "C1153455", "aliases": [], "types": ["T044"], "definition": "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. [GOC:mah, PMID:11343411, PMID:2462513]", "canonical_name": "delayed rectifier potassium channel activity"}
{"concept_id": "C1153456", "aliases": ["inward rectifier potassium channel activity"], "types": ["T044"], "definition": "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. [GOC:cb, GOC:mah, PMID:14977398]", "canonical_name": "Kir channel activity"}
{"concept_id": "C1153457", "aliases": [], "types": ["T044"], "canonical_name": "ATP-activated inward rectifier potassium channel activity", "definition": "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. [GOC:cb, GOC:mah]"}
{"concept_id": "C1153458", "aliases": ["G protein activated inward rectifier potassium channel activity", "G-protein enhanced inward rectifier potassium channel activity", "G-protein-activated inward rectifier potassium channel activity", "G-protein-enhanced inward rectifier potassium channel activity", "G protein enhanced inward rectifier potassium channel activity"], "types": ["T044"], "canonical_name": "G-protein activated inward rectifier potassium channel activity", "definition": "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. [GOC:cb, GOC:mah]"}
{"concept_id": "C1153460", "aliases": [], "types": ["T044"], "definition": "Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration. [GOC:mah, PMID:8917578]", "canonical_name": "open rectifier potassium channel activity"}
{"concept_id": "C1153461", "aliases": [], "types": ["T044"], "canonical_name": "outward rectifier potassium channel activity", "definition": "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. [GOC:mah]"}
{"concept_id": "C1153462", "aliases": [], "types": ["T044"], "canonical_name": "A-type (transient outward) potassium channel activity", "definition": "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential. [GOC:mah, PMID:5575340]"}
{"concept_id": "C1153463", "aliases": [], "types": ["T044"], "definition": "Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "canonical_name": "sodium channel activity"}
{"concept_id": "C1153464", "aliases": ["ligand-gated sodium channel activity"], "types": ["T044"], "definition": "Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]", "canonical_name": "amiloride-sensitive sodium channel activity"}
{"concept_id": "C1153465", "aliases": ["voltage-dependent sodium channel activity", "voltage gated sodium channel activity", "voltage-gated sodium ion channel activity", "voltage-sensitive sodium channel"], "types": ["T044"], "canonical_name": "voltage-gated sodium channel activity", "definition": "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153467", "aliases": [], "types": ["T044"], "canonical_name": "extracellular ligand-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153468", "aliases": [], "types": ["T044"], "canonical_name": "excitatory extracellular ligand-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. [GOC:mah, ISBN:0323037070]"}
{"concept_id": "C1153469", "aliases": ["extracellular-glycine-gated ion channel activity"], "types": ["T044"], "canonical_name": "extracellularly glycine-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153470", "aliases": [], "types": ["T044"], "canonical_name": "inhibitory extracellular ligand-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels. [GOC:mah, ISBN:0323037070]"}
{"concept_id": "C1153471", "aliases": [], "types": ["T044"], "canonical_name": "intracellular ligand-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153472", "aliases": ["mechanically gated channel activity", "mechanically-gated channel activity", "mechanically-gated ion channel activity"], "types": ["T044"], "canonical_name": "mechanosensitive ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153480", "aliases": ["sugar/polyol channel activity"], "types": ["T044"], "canonical_name": "sugar/polyol channel activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153481", "aliases": [], "types": ["T044"], "canonical_name": "glycerol channel activity", "definition": "Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153482", "aliases": [], "types": ["T044"], "canonical_name": "propanediol channel activity", "definition": "Enables the facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport]"}
{"concept_id": "C1153483", "aliases": ["voltage-dependent ion channel activity", "voltage gated ion channel activity"], "types": ["T044"], "canonical_name": "voltage-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1153484", "aliases": ["voltage-dependent proton channel activity", "voltage gated proton channel activity"], "types": ["T044"], "canonical_name": "voltage-gated proton channel activity", "definition": "Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [PMID:28774948]"}
{"concept_id": "C1153489", "aliases": [], "types": ["T044"], "definition": "Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "water channel activity"}
{"concept_id": "C1153490", "aliases": ["porin activity"], "types": ["T044"], "definition": "Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-]", "canonical_name": "porin"}
{"concept_id": "C1153491", "aliases": [], "types": ["T044"], "canonical_name": "autotransporter activity", "definition": "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively. [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-]"}
{"concept_id": "C1153492", "aliases": [], "types": ["T044"], "canonical_name": "adhesin autotransporter activity", "definition": "Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153493", "aliases": [], "types": ["T044"], "canonical_name": "hemaglutinin autotransporter activity", "definition": "Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153494", "aliases": [], "types": ["T044"], "canonical_name": "fimbrial usher porin activity", "definition": "A porin that acts in the assembly of fimbria together with fimbrial chaperone. [TC:1.B.11.-.-]"}
{"concept_id": "C1153495", "aliases": [], "types": ["T044"], "canonical_name": "long-chain fatty acid transporting porin activity", "definition": "Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport, TC:1.B.9.1.1]"}
{"concept_id": "C1153496", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside-specific channel forming porin activity", "definition": "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport]"}
{"concept_id": "C1153497", "aliases": [], "types": ["T044"], "canonical_name": "outer membrane exporter porin", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1153499", "aliases": [], "types": ["T044"], "canonical_name": "toxin export channel activity", "definition": "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport]"}
{"concept_id": "C1153501", "aliases": ["acriflavin transporter activity"], "types": ["T044"], "canonical_name": "acriflavine transporter activity"}
{"concept_id": "C1153502", "aliases": [], "types": ["T044"], "canonical_name": "acriflavin resistant pump activity"}
{"concept_id": "C1153503", "aliases": [], "types": ["T044"], "canonical_name": "alkane transmembrane transporter activity", "definition": "Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds. [GOC:ai]"}
{"concept_id": "C1153504", "aliases": [], "types": ["T044"], "canonical_name": "multidrug, alkane resistant pump activity"}
{"concept_id": "C1153505", "aliases": [], "types": ["T044"], "canonical_name": "amiloride transporter activity"}
{"concept_id": "C1153508", "aliases": [], "types": ["T044"], "canonical_name": "fluconazole transporter activity"}
{"concept_id": "C1153509", "aliases": ["sulphathiazole transporter activity"], "types": ["T044"], "canonical_name": "sulfathiazole transmembrane transporter activity", "definition": "Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group. [GOC:curators]"}
{"concept_id": "C1153511", "aliases": [], "types": ["T044"], "canonical_name": "bicyclomycin transporter activity"}
{"concept_id": "C1153512", "aliases": ["carbonyl cyanide m-chlorophenylhydrazone transporter activity", "CCCP transporter activity"], "types": ["T044"], "canonical_name": "carbonyl cyanide m-chlorophenylhydrazone transmembrane transporter activity", "definition": "Enables the transfer of carbonyl cyanide m-chlorophenylhydrazone from one side of a membrane to the other. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. [GOC:curators]"}
{"concept_id": "C1153513", "aliases": [], "types": ["T044"], "canonical_name": "cycloheximide transporter activity"}
{"concept_id": "C1153514", "aliases": ["microcin uptake permease activity"], "types": ["T044"], "canonical_name": "microcin transmembrane transporter activity", "definition": "Enables the transfer of a microcin from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C1153515", "aliases": [], "types": ["T044"], "canonical_name": "multidrug transporter activity"}
{"concept_id": "C1153516", "aliases": [], "types": ["T044"], "canonical_name": "multidrug efflux pump activity"}
{"concept_id": "C1153517", "aliases": [], "types": ["T044"], "canonical_name": "nalidixic acid transporter activity"}
{"concept_id": "C1153518", "aliases": [], "types": ["T044"], "canonical_name": "organomercurial transporter activity"}
{"concept_id": "C1153519", "aliases": ["tetracycline transporter activity", "tetracyclin transporter activity"], "types": ["T044"], "canonical_name": "tetracycline transmembrane transporter activity", "definition": "Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). [GOC:curators]"}
{"concept_id": "C1153520", "aliases": [], "types": ["T044"], "canonical_name": "triose-phosphate transmembrane transporter activity", "definition": "Enables the transfer of a triose phosphate from one side of a membrane to the other. [GOC:mah, GOC:vw]"}
{"concept_id": "C1153522", "aliases": [], "types": ["T044"], "canonical_name": "electron acceptor activity"}
{"concept_id": "C1153523", "aliases": [], "types": ["T044"], "canonical_name": "electron donor activity"}
{"concept_id": "C1153525", "aliases": [], "types": ["T044"], "definition": "Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II. [GOC:ai, ISBN:0716731363]", "canonical_name": "electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity"}
{"concept_id": "C1153526", "aliases": ["soluble cytochrome b562"], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "cytochrome b562"}
{"concept_id": "C1153527", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "cytochrome b6"}
{"concept_id": "C1153528", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A cytochrome containing heme a. [GOC:kd]", "canonical_name": "cytochrome a"}
{"concept_id": "C1153529", "aliases": [], "types": ["T044"], "definition": "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. [GOC:ai, ISBN:0716731363]", "canonical_name": "electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"}
{"concept_id": "C1153530", "aliases": [], "types": ["T044"], "canonical_name": "electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity", "definition": "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis. [GOC:ai, ISBN:0716731363]"}
{"concept_id": "C1153536", "aliases": [], "types": ["T044"], "canonical_name": "group translocator activity"}
{"concept_id": "C1153538", "aliases": [], "types": ["T044"], "canonical_name": "intracellular nucleoside transmembrane transporter activity", "definition": "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell. [GOC:ai]"}
{"concept_id": "C1153540", "aliases": ["SNARE", "Q-SNARE activity"], "types": ["T044"], "definition": "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. [GOC:mah, PMID:14570579]", "canonical_name": "SNAP receptor activity"}
{"concept_id": "C1153541", "aliases": [], "types": ["T044"], "canonical_name": "t-SNARE activity"}
{"concept_id": "C1153542", "aliases": [], "types": ["T044"], "canonical_name": "v-SNARE activity"}
{"concept_id": "C1153543", "aliases": ["SNAP"], "types": ["T044"], "definition": "Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex. [GOC:mah, PMID:14570579, PMID:15556857]", "canonical_name": "soluble NSF attachment protein activity"}
{"concept_id": "C1153544", "aliases": ["ion transporter activity"], "types": ["T044"], "canonical_name": "ion transmembrane transporter activity", "definition": "Enables the transfer of an ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153545", "aliases": ["anion transporter activity"], "types": ["T044"], "canonical_name": "anion transmembrane transporter activity", "definition": "Enables the transfer of a negatively charged ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153547", "aliases": [], "types": ["T044"], "canonical_name": "antimonite transmembrane transporter activity", "definition": "Enables the transfer of antimonite from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153548", "aliases": [], "types": ["T044"], "canonical_name": "arsenite transmembrane transporter activity", "definition": "Enables the transfer of arsenite from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153549", "aliases": [], "types": ["T044"], "canonical_name": "bicarbonate transmembrane transporter activity", "definition": "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. [GOC:ai]"}
{"concept_id": "C1153550", "aliases": [], "types": ["T044"], "canonical_name": "chlorate transmembrane transporter activity", "definition": "Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other. [GOC:curators]"}
{"concept_id": "C1153551", "aliases": ["chloride ion transmembrane transporter activity"], "types": ["T044"], "canonical_name": "chloride transmembrane transporter activity", "definition": "Enables the transfer of chloride ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153552", "aliases": [], "types": ["T044"], "canonical_name": "chromate transmembrane transporter activity", "definition": "Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3. [GOC:ai]"}
{"concept_id": "C1153553", "aliases": [], "types": ["T044"], "canonical_name": "cyanate transmembrane transporter activity", "definition": "Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153554", "aliases": ["inorganic pyrophosphate transporter activity"], "types": ["T044"], "canonical_name": "inorganic diphosphate transmembrane transporter activity", "definition": "Enables the transfer of inorganic diphosphate across a membrane. [PMID:11326272]"}
{"concept_id": "C1153555", "aliases": [], "types": ["T044"], "canonical_name": "iodide transmembrane transporter activity", "definition": "Enables the transfer of iodide ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153556", "aliases": [], "types": ["T044"], "canonical_name": "nitrate transmembrane transporter activity", "definition": "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. [GOC:ai, RHEA:34923]"}
{"concept_id": "C1153557", "aliases": [], "types": ["T044"], "canonical_name": "nitrite transmembrane transporter activity", "definition": "Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153558", "aliases": ["phosphate transmembrane transporter activity"], "types": ["T044"], "canonical_name": "phosphate ion transmembrane transporter activity", "definition": "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153559", "aliases": [], "types": ["T044"], "canonical_name": "silicate transmembrane transporter activity", "definition": "Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. [GOC:ai]"}
{"concept_id": "C1153560", "aliases": ["sulphate transporter activity"], "types": ["T044"], "definition": "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. [GOC:ai]", "canonical_name": "sulfate transmembrane transporter activity"}
{"concept_id": "C1153561", "aliases": ["nucleotide-sulphate transporter activity"], "types": ["T044"], "canonical_name": "nucleotide-sulfate transmembrane transporter activity", "definition": "Enables the transfer of nucleotide-sulfate from one side of a membrane to the other. [GOC:mtg_transport]"}
{"concept_id": "C1153562", "aliases": ["sulphite transporter activity"], "types": ["T044"], "canonical_name": "sulfite transmembrane transporter activity", "definition": "Enables the transfer of sulfite ions from one side of a membrane to the other. [GOC:as]"}
{"concept_id": "C1153564", "aliases": ["thiosulphate transporter activity"], "types": ["T044"], "canonical_name": "thiosulfate transmembrane transporter activity", "definition": "Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153567", "aliases": ["alpha-ketoglutarate transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. [GOC:ai, ISBN:0198547684]", "canonical_name": "2-oxoglutarate transporter activity"}
{"concept_id": "C1153570", "aliases": [], "types": ["T044"], "canonical_name": "malate transmembrane transporter activity", "definition": "Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. [GOC:ai]"}
{"concept_id": "C1153571", "aliases": ["sodium:dicarboxylate cotransporter activity"], "types": ["T044"], "canonical_name": "sodium:dicarboxylate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). [GOC:ai]"}
{"concept_id": "C1153574", "aliases": [], "types": ["T044"], "canonical_name": "hexose phosphate transmembrane transporter activity", "definition": "Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153575", "aliases": [], "types": ["T044"], "canonical_name": "monocarboxylic acid transmembrane transporter activity", "definition": "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. [GOC:ai]"}
{"concept_id": "C1153576", "aliases": [], "types": ["T044"], "canonical_name": "acetate transmembrane transporter activity", "definition": "Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid. [GOC:ai]"}
{"concept_id": "C1153577", "aliases": [], "types": ["T044"], "canonical_name": "allantoate transmembrane transporter activity", "definition": "Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen. [GOC:ai, ISBN:0198547684]"}
{"concept_id": "C1153578", "aliases": [], "types": ["T044"], "canonical_name": "bile acid transmembrane transporter activity", "definition": "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:ai]"}
{"concept_id": "C1153580", "aliases": [], "types": ["T044"], "canonical_name": "bilirubin transmembrane transporter activity", "definition": "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile. [GOC:ai, ISBN:0198547684]"}
{"concept_id": "C1153581", "aliases": ["formate uptake permease activity"], "types": ["T044"], "canonical_name": "formate transmembrane transporter activity", "definition": "Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. [GOC:ai]"}
{"concept_id": "C1153582", "aliases": [], "types": ["T044"], "canonical_name": "gluconate transmembrane transporter activity", "definition": "Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1153583", "aliases": [], "types": ["T044"], "canonical_name": "L-idonate transmembrane transporter activity", "definition": "Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. [GOC:ai]"}
{"concept_id": "C1153584", "aliases": [], "types": ["T044"], "canonical_name": "lactate transmembrane transporter activity", "definition": "Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1153585", "aliases": [], "types": ["T044"], "canonical_name": "mevalonate transmembrane transporter activity", "definition": "Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1153587", "aliases": [], "types": ["T044"], "canonical_name": "propionate transmembrane transporter activity", "definition": "Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH. [GOC:ai]"}
{"concept_id": "C1153588", "aliases": ["3-hydroxyphenyl propionate transmembrane transporter activity"], "types": ["T044"], "canonical_name": "3-hydroxyphenyl propanoate transmembrane transporter activity", "definition": "Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153589", "aliases": [], "types": ["T044"], "canonical_name": "prostaglandin transmembrane transporter activity", "definition": "Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [GOC:ai]"}
{"concept_id": "C1153590", "aliases": [], "types": ["T044"], "canonical_name": "pyruvate carrier activity"}
{"concept_id": "C1153591", "aliases": [], "types": ["T044"], "canonical_name": "shikimate transmembrane transporter activity", "definition": "Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids. [GOC:ai]"}
{"concept_id": "C1153592", "aliases": [], "types": ["T044"], "canonical_name": "uronic acid transmembrane transporter activity", "definition": "Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. [GOC:ai]"}
{"concept_id": "C1153593", "aliases": ["hexuronide transmembrane transporter activity"], "types": ["T044"], "canonical_name": "hexuronate transmembrane transporter activity", "definition": "Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6. [GOC:ai, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1153594", "aliases": [], "types": ["T044"], "canonical_name": "galacturonate transmembrane transporter activity", "definition": "Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. [GOC:ai]"}
{"concept_id": "C1153595", "aliases": [], "types": ["T044"], "canonical_name": "glucuronate transmembrane transporter activity", "definition": "Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. [GOC:ai]"}
{"concept_id": "C1153596", "aliases": ["phosphoenolpyruvate/phosphate translocator", "phosphoenolpyruvate:phosphate antiporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out). [GOC:bf, GOC:jl]", "canonical_name": "PPT"}
{"concept_id": "C1153597", "aliases": [], "types": ["T044"], "canonical_name": "phosphoglycerate transmembrane transporter activity", "definition": "Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis. [GOC:ai]"}
{"concept_id": "C1153599", "aliases": [], "types": ["T044"], "canonical_name": "tricarboxylic acid transmembrane transporter activity", "definition": "Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups. [GOC:ai]"}
{"concept_id": "C1153600", "aliases": [], "types": ["T044"], "canonical_name": "citrate transmembrane transporter activity", "definition": "Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153601", "aliases": ["uric acid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "urate transmembrane transporter activity", "definition": "Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. [GOC:ai]"}
{"concept_id": "C1153602", "aliases": [], "types": ["T044"], "canonical_name": "organophosphate ester transmembrane transporter activity", "definition": "Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. [GOC:mcc]"}
{"concept_id": "C1153604", "aliases": [], "types": ["T044"], "canonical_name": "di-, tri-valent inorganic cation transmembrane transporter activity"}
{"concept_id": "C1153605", "aliases": ["aluminium ion transporter activity", "aluminum resistance permease activity", "aluminium resistance permease activity"], "types": ["T044"], "canonical_name": "aluminum ion transmembrane transporter activity", "definition": "Enables the transfer of aluminum (Al) ions from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153607", "aliases": [], "types": ["T044"], "canonical_name": "calcium ion transmembrane transporter activity", "definition": "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. [GOC:dgf, RHEA:29671]"}
{"concept_id": "C1153608", "aliases": [], "types": ["T044"], "canonical_name": "magnesium ion transmembrane transporter activity", "definition": "Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. [GOC:dgf]"}
{"concept_id": "C1153609", "aliases": [], "types": ["T044"], "canonical_name": "heavy metal ion transporter activity", "definition": "OBSOLETE. Enables the directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. [GOC:ai]"}
{"concept_id": "C1153611", "aliases": ["proton transporter activity", "hydrogen ion transmembrane transporter activity"], "types": ["T044"], "canonical_name": "proton transmembrane transporter activity", "definition": "Enables the transfer of a proton from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153614", "aliases": [], "types": ["T044"], "canonical_name": "organic cation transmembrane transporter activity", "definition": "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153615", "aliases": ["ammonia transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ammonium transmembrane transporter activity", "definition": "Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. [PMID:17710640]"}
{"concept_id": "C1153616", "aliases": ["quaternary amine transmembrane transporter activity", "quaternary ammonium compound transporter activity"], "types": ["T044"], "canonical_name": "quaternary ammonium group transmembrane transporter activity", "definition": "Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [ISBN:0198506732]"}
{"concept_id": "C1153618", "aliases": [], "types": ["T044"], "definition": "Enables the directed movement of lipids into, out of or within a cell, or between cells. [GOC:ai]", "canonical_name": "lipid transporter activity"}
{"concept_id": "C1153619", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid transporter activity"}
{"concept_id": "C1153620", "aliases": [], "types": ["T044"], "canonical_name": "long-chain fatty acid transporter activity", "definition": "Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [ISBN:0198506732]"}
{"concept_id": "C1153623", "aliases": [], "types": ["T044"], "canonical_name": "short-chain fatty acid uptake transporter activity"}
{"concept_id": "C1153627", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects. [ISBN:0198506732]", "canonical_name": "lipophorin"}
{"concept_id": "C1153629", "aliases": [], "types": ["T044"], "canonical_name": "sterol transporter activity", "definition": "Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:ai]"}
{"concept_id": "C1153630", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol transporter activity"}
{"concept_id": "C1153631", "aliases": ["murein transporter activity"], "types": ["T044"], "canonical_name": "peptidoglycan transmembrane transporter activity", "definition": "Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153632", "aliases": ["lipid-linked murein transporter activity"], "types": ["T044"], "canonical_name": "lipid-linked peptidoglycan transporter activity", "definition": "Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells. [GOC:mah]"}
{"concept_id": "C1153633", "aliases": ["muropeptide transporter activity", "murein peptide transporter activity"], "types": ["T044"], "canonical_name": "peptidoglycan peptide transmembrane transporter activity", "definition": "Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains. [ISBN:0198506732]"}
{"concept_id": "C1153634", "aliases": ["neurotransmitter transporter activity"], "types": ["T044"], "canonical_name": "neurotransmitter transmembrane transporter activity", "definition": "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1153638", "aliases": [], "types": ["T044"], "canonical_name": "nucleobase transmembrane transporter activity", "definition": "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. [ISBN:0198506732]"}
{"concept_id": "C1153640", "aliases": ["purine base transmembrane transporter activity", "purine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "purine nucleobase transmembrane transporter activity", "definition": "Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. [ISBN:0198506732]"}
{"concept_id": "C1153641", "aliases": [], "types": ["T044"], "canonical_name": "adenine transmembrane transporter activity", "definition": "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C1153642", "aliases": [], "types": ["T044"], "canonical_name": "guanine transmembrane transporter activity", "definition": "Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C1153643", "aliases": ["pyrimidine base transmembrane transporter activity", "pyrimidine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "pyrimidine nucleobase transmembrane transporter activity", "definition": "Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153644", "aliases": [], "types": ["T044"], "canonical_name": "cytosine transmembrane transporter activity", "definition": "Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C1153645", "aliases": [], "types": ["T044"], "canonical_name": "uracil transmembrane transporter activity", "definition": "Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C1153646", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside transmembrane transporter activity", "definition": "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153648", "aliases": [], "types": ["T044"], "canonical_name": "cytidine transmembrane transporter activity", "definition": "Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C1153649", "aliases": [], "types": ["T044"], "canonical_name": "uridine transmembrane transporter activity", "definition": "Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C1153650", "aliases": [], "types": ["T044"], "canonical_name": "xanthosine transmembrane transporter activity", "definition": "Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other. [ISBN:0198506732]"}
{"concept_id": "C1153652", "aliases": [], "types": ["T044"], "canonical_name": "nucleotide transmembrane transporter activity", "definition": "Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. [ISBN:0198506732]"}
{"concept_id": "C1153653", "aliases": [], "types": ["T045"], "canonical_name": "deoxynucleotide transmembrane transporter activity", "definition": "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP. [PMID:11226231]"}
{"concept_id": "C1153654", "aliases": [], "types": ["T044"], "canonical_name": "purine nucleotide transmembrane transporter activity", "definition": "Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153655", "aliases": [], "types": ["T044"], "canonical_name": "adenine nucleotide transmembrane transporter activity", "definition": "Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other. [PMID:11566870]"}
{"concept_id": "C1153656", "aliases": [], "types": ["T044"], "canonical_name": "ADP transmembrane transporter activity", "definition": "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153657", "aliases": [], "types": ["T044"], "canonical_name": "ATP transmembrane transporter activity", "definition": "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153658", "aliases": [], "types": ["T044"], "canonical_name": "purine ribonucleotide transmembrane transporter activity", "definition": "Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153659", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine nucleotide transmembrane transporter activity", "definition": "Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153661", "aliases": ["oxalic acid transporter activity"], "types": ["T044"], "canonical_name": "oxalate transmembrane transporter activity", "definition": "Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. [ISBN:0198506732]"}
{"concept_id": "C1153663", "aliases": ["active carrier activity", "carrier activity", "pump activity", "active transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. [GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "permease activity"}
{"concept_id": "C1153664", "aliases": ["efflux transporter activity", "efflux permease activity"], "types": ["T044"], "canonical_name": "efflux transmembrane transporter activity", "definition": "Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153665", "aliases": ["cation efflux permease activity"], "types": ["T044"], "canonical_name": "cation efflux transmembrane transporter activity", "definition": "Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153666", "aliases": [], "types": ["T044"], "canonical_name": "polyol transmembrane transporter activity", "definition": "Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol. [ISBN:0198506732]"}
{"concept_id": "C1153667", "aliases": ["arabinitol transporter activity"], "types": ["T044"], "canonical_name": "arabitol transmembrane transporter activity", "definition": "Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. [ISBN:0198506732]"}
{"concept_id": "C1153670", "aliases": [], "types": ["T044"], "canonical_name": "glycerol transmembrane transporter activity", "definition": "Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. [GOC:ai]"}
{"concept_id": "C1153671", "aliases": [], "types": ["T044"], "canonical_name": "glycerol-3-phosphate transmembrane transporter activity", "definition": "Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol. [GOC:ai]"}
{"concept_id": "C1153673", "aliases": ["vitamin Bh transporter activity"], "types": ["T044"], "canonical_name": "myo-inositol transmembrane transporter activity", "definition": "Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. [GOC:ai]"}
{"concept_id": "C1153674", "aliases": [], "types": ["T044"], "canonical_name": "propanediol transmembrane transporter activity", "definition": "Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects. [GOC:ai]"}
{"concept_id": "C1153683", "aliases": [], "types": ["T044"], "canonical_name": "toxin transmembrane transporter activity", "definition": "Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. [ISBN:0198506732]"}
{"concept_id": "C1153684", "aliases": [], "types": ["T044"], "canonical_name": "vitamin or cofactor transporter activity", "definition": "OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of or within a cell, or between cells. [GOC:ai]"}
{"concept_id": "C1153685", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA transporter activity"}
{"concept_id": "C1153686", "aliases": [], "types": ["T044"], "canonical_name": "biopterin transporter activity"}
{"concept_id": "C1153687", "aliases": ["biotin transporter activity", "vitamin B7 transporter activity"], "types": ["T044"], "canonical_name": "vitamin H transporter activity"}
{"concept_id": "C1153688", "aliases": ["carnitine transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:ai]", "canonical_name": "vitamin Bt transporter activity"}
{"concept_id": "C1153689", "aliases": ["acylcarnitine transporter activity"], "types": ["T044"], "canonical_name": "acyl carnitine transmembrane transporter activity", "definition": "Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane. [GOC:ai]"}
{"concept_id": "C1153690", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme A transporter activity"}
{"concept_id": "C1153692", "aliases": [], "types": ["T044"], "canonical_name": "FAD transporter activity"}
{"concept_id": "C1153693", "aliases": ["vitamin M transporter activity", "folic acid transporter activity", "folate transmembrane transporter activity", "folate transporter activity", "vitamin B9 transporter activity"], "types": ["T044"], "canonical_name": "folic acid transmembrane transporter activity", "definition": "Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:ai]"}
{"concept_id": "C1153694", "aliases": ["5-formyltetrahydrofolate transporter activity"], "types": ["T044"], "canonical_name": "5-formyltetrahydrofolate transmembrane transporter activity", "definition": "Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1153695", "aliases": ["heme transporter activity", "haem transporter activity"], "types": ["T044"], "canonical_name": "heme transmembrane transporter activity", "definition": "Enables the transfer of heme from one side of a membrane to the other. [PMID:29549126]"}
{"concept_id": "C1153696", "aliases": ["L-ascorbate transporter activity", "vitamin C transporter activity"], "types": ["T044"], "canonical_name": "L-ascorbic acid transmembrane transporter activity", "definition": "Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species. [ISBN:0198506732]"}
{"concept_id": "C1153698", "aliases": [], "types": ["T044"], "canonical_name": "nicotinamide mononucleotide permease activity"}
{"concept_id": "C1153699", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate transporter activity"}
{"concept_id": "C1153700", "aliases": ["vitamin B1 transporter activity", "thiamine permease activity", "thiamin transmembrane transporter activity", "thiamin permease activity"], "types": ["T044"], "canonical_name": "thiamine transmembrane transporter activity", "definition": "Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1153703", "aliases": ["tRNA", "transfer RNA"], "types": ["T045"], "definition": "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis. [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732]", "canonical_name": "triplet codon-amino acid adaptor activity"}
{"concept_id": "C1154314", "aliases": ["adult behavior", "adult behaviour", "adult behavioral response to stimulus"], "types": ["T055"], "definition": "Behavior in a fully developed and mature organism. [GOC:mah, ISBN:0877797099]", "canonical_name": "adult behavioural response to stimulus"}
{"concept_id": "C1154319", "aliases": ["adult feeding behaviour"], "types": ["T055"], "canonical_name": "adult feeding behavior", "definition": "Feeding behavior in a fully developed and mature organism. [GOC:mah]"}
{"concept_id": "C1154321", "aliases": ["adult locomotory behaviour"], "types": ["T055"], "canonical_name": "adult locomotory behavior", "definition": "Locomotory behavior in a fully developed and mature organism. [GOC:ai]"}
{"concept_id": "C1154322", "aliases": ["adult walking behaviour"], "types": ["T055"], "canonical_name": "adult walking behavior", "definition": "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. [GOC:jid, GOC:pr, ISBN:0198606907]"}
{"concept_id": "C1154323", "aliases": ["flight behaviour"], "types": ["T055"], "canonical_name": "flight behavior", "definition": "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air. [GOC:jid, ISBN:0198606907]"}
{"concept_id": "C1154324", "aliases": [], "types": ["T055"], "canonical_name": "jump response", "definition": "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus. [GOC:jid, ISBN:0198606907]"}
{"concept_id": "C1154325", "aliases": ["behavioural fear response"], "types": ["T055"], "canonical_name": "behavioral fear response", "definition": "An acute behavioral change resulting from a perceived external threat. [GOC:dph, PMID:9920659]"}
{"concept_id": "C1154326", "aliases": ["behavioral response to chemical stimulus", "behavioural response to chemical stimulus", "chemosensory behaviour"], "types": ["T055"], "canonical_name": "chemosensory behavior", "definition": "Behavior that is dependent upon the sensation of chemicals. [GOC:go_curators]"}
{"concept_id": "C1154327", "aliases": ["jump response to chemical stimulus", "chemosensory jump behaviour"], "types": ["T055"], "canonical_name": "chemosensory jump behavior", "definition": "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance. [GOC:jid]"}
{"concept_id": "C1154328", "aliases": ["behavioral response to scent", "behavioural response to smell", "behavioural response to scent", "behavioral response to smell", "behavioural response to odour", "olfactory behaviour"], "types": ["T055"], "canonical_name": "olfactory behavior", "definition": "The behavior of an organism in response to an odor. [GOC:jid, GOC:pr]"}
{"concept_id": "C1154329", "aliases": ["proboscis extension in response to nutritional stimulus", "behavioral response to nutritional stimulus, proboscis extension"], "types": ["T040"], "canonical_name": "proboscis extension reflex", "definition": "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus. [FB:FBrf0044924, GOC:jid]"}
{"concept_id": "C1154330", "aliases": ["larval feeding behaviour"], "types": ["T055"], "canonical_name": "larval feeding behavior", "definition": "Feeding behavior in a larval (immature) organism. [GOC:mah]"}
{"concept_id": "C1154333", "aliases": ["grooming behaviour"], "types": ["T055"], "canonical_name": "grooming behavior", "definition": "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. [GOC:jl, GOC:pr]"}
{"concept_id": "C1154334", "aliases": ["larval behaviour"], "types": ["T055"], "canonical_name": "larval behavior", "definition": "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics. [GOC:mah, ISBN:0877797099]"}
{"concept_id": "C1154336", "aliases": ["larval locomotory behaviour"], "types": ["T055"], "canonical_name": "larval locomotory behavior", "definition": "Locomotory behavior in a larval (immature) organism. [GOC:ai]"}
{"concept_id": "C1154337", "aliases": ["larval walking behaviour"], "types": ["T055"], "canonical_name": "larval walking behavior", "definition": "The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. [GOC:go_curators, GOC:pr]"}
{"concept_id": "C1154338", "aliases": [], "types": ["T041"], "definition": "The acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125]", "canonical_name": "learning or memory"}
{"concept_id": "C1154340", "aliases": [], "types": ["T041"], "definition": "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. [ISBN:0582227089]", "canonical_name": "olfactory learning"}
{"concept_id": "C1154341", "aliases": [], "types": ["T055"], "canonical_name": "vocal learning", "definition": "A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others. [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]"}
{"concept_id": "C1154342", "aliases": [], "types": ["T041"], "canonical_name": "anesthesia-resistant memory", "definition": "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis. [PMID:15143285, PMID:17088531]"}
{"concept_id": "C1154343", "aliases": ["behavior via locomotion", "locomotory behaviour", "locomotory behavioral response to stimulus", "locomotion in response to stimulus", "locomotory behavioural response to stimulus"], "types": ["T055"], "canonical_name": "locomotory behavior", "definition": "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]"}
{"concept_id": "C1154344", "aliases": [], "types": ["T040"], "canonical_name": "regulation of locomotion", "definition": "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. [GOC:ems]"}
{"concept_id": "C1154345", "aliases": ["down regulation of locomotion", "downregulation of locomotion", "down-regulation of locomotion"], "types": ["T040"], "canonical_name": "negative regulation of locomotion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. [GOC:go_curators]"}
{"concept_id": "C1154346", "aliases": ["up regulation of locomotion", "upregulation of locomotion", "up-regulation of locomotion"], "types": ["T040"], "canonical_name": "positive regulation of locomotion", "definition": "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. [GOC:go_curators]"}
{"concept_id": "C1154347", "aliases": [], "types": ["T055"], "canonical_name": "locomotor rhythm", "definition": "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle. [GOC:go_curators]"}
{"concept_id": "C1154348", "aliases": ["behavioural response to mechanical stimulus", "mechanosensory behaviour", "behavioral response to mechanical stimulus"], "types": ["T040"], "canonical_name": "mechanosensory behavior", "definition": "Behavior that is dependent upon the sensation of a mechanical stimulus. [GOC:go_curators]"}
{"concept_id": "C1154349", "aliases": ["mating behaviour"], "types": ["T040"], "canonical_name": "mating behavior", "definition": "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. [GOC:ai, GOC:dph]"}
{"concept_id": "C1154350", "aliases": ["courtship behaviour"], "types": ["T054"], "canonical_name": "courtship behavior", "definition": "The behavior of an organism for the purpose of attracting sexual partners. [GOC:ai, GOC:dph]"}
{"concept_id": "C1154351", "aliases": ["female courtship behaviour"], "types": ["T054"], "canonical_name": "female courtship behavior", "definition": "The behavior of a female, for the purpose of attracting a sexual partner. [GOC:bf, GOC:pr]"}
{"concept_id": "C1154352", "aliases": ["male courtship behaviour"], "types": ["T054"], "canonical_name": "male courtship behavior", "definition": "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, GOC:pr]"}
{"concept_id": "C1154360", "aliases": [], "types": ["T040"], "canonical_name": "regulation of female receptivity, post-mating", "definition": "Any process that modulates the receptiveness of a female to male advances subsequent to mating. [GOC:go_curators]"}
{"concept_id": "C1154361", "aliases": ["down-regulation of female receptivity, post-mating", "downregulation of female receptivity, post-mating", "down regulation of female receptivity, post-mating"], "types": ["T040"], "canonical_name": "negative regulation of female receptivity, post-mating", "definition": "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating. [GOC:bf, PMID:11092827]"}
{"concept_id": "C1154362", "aliases": ["up regulation of female receptivity, post-mating", "upregulation of female receptivity, post-mating", "up-regulation of female receptivity, post-mating"], "types": ["T040"], "canonical_name": "positive regulation of female receptivity, post-mating", "definition": "Any process that increases the receptiveness of a female to male advances subsequent to mating. [GOC:go_curators]"}
{"concept_id": "C1154363", "aliases": [], "types": ["T040"], "canonical_name": "regulation of female receptivity", "definition": "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1154364", "aliases": ["down-regulation of female receptivity", "downregulation of female receptivity", "down regulation of female receptivity"], "types": ["T040"], "canonical_name": "negative regulation of female receptivity", "definition": "Any process that stops, prevents or reduces the receptiveness of a female to male advances. [GOC:bf, PMID:11092827]"}
{"concept_id": "C1154365", "aliases": ["up-regulation of female receptivity", "up regulation of female receptivity", "upregulation of female receptivity"], "types": ["T040"], "canonical_name": "positive regulation of female receptivity", "definition": "Any process that activates or increases the receptiveness of a female to male advances. [GOC:go_curators]"}
{"concept_id": "C1154366", "aliases": [], "types": ["T040"], "canonical_name": "regulation of oviposition", "definition": "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium. [GOC:dph, GOC:tb, PMID:11932766]"}
{"concept_id": "C1154367", "aliases": ["rhythmic behaviour", "rhythmic behavioral response to stimulus", "rhythmic behavioural response to stimulus"], "types": ["T055"], "canonical_name": "rhythmic behavior", "definition": "The specific behavior of an organism that recur with measured regularity. [GOC:jl, GOC:pr]"}
{"concept_id": "C1154368", "aliases": [], "types": ["T040"], "canonical_name": "eclosion rhythm", "definition": "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn. [PMID:11715043]"}
{"concept_id": "C1154369", "aliases": [], "types": ["T055"], "canonical_name": "entrainment of circadian clock", "definition": "The synchronization of a circadian rhythm to environmental time cues such as light. [GOC:jid]"}
{"concept_id": "C1154370", "aliases": ["down-regulation of circadian sleep/wake cycle, sleep", "downregulation of circadian sleep/wake cycle, sleep", "down regulation of circadian sleep/wake cycle, sleep", "negative regulation of sleep"], "types": ["T040"], "canonical_name": "negative regulation of circadian sleep/wake cycle, sleep", "definition": "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. [GOC:go_curators, GOC:jl, ISBN:0192800981]"}
{"concept_id": "C1154371", "aliases": ["negative regulation of non-REM sleep", "down regulation of circadian sleep/wake cycle, non-REM sleep", "downregulation of circadian sleep/wake cycle, non-REM sleep", "down-regulation of circadian sleep/wake cycle, non-REM sleep"], "types": ["T040"], "canonical_name": "negative regulation of circadian sleep/wake cycle, non-REM sleep", "definition": "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep. [GOC:jl]"}
{"concept_id": "C1154372", "aliases": ["down regulation of circadian sleep/wake cycle, REM sleep", "downregulation of circadian sleep/wake cycle, REM sleep", "down-regulation of circadian sleep/wake cycle, REM sleep", "negative regulation of REM sleep"], "types": ["T040"], "canonical_name": "negative regulation of circadian sleep/wake cycle, REM sleep", "definition": "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep. [GOC:go_curators, GOC:jl]"}
{"concept_id": "C1154373", "aliases": ["upregulation of circadian sleep/wake cycle, sleep", "positive regulation of sleep", "up regulation of circadian sleep/wake cycle, sleep", "up-regulation of circadian sleep/wake cycle, sleep"], "types": ["T040"], "canonical_name": "positive regulation of circadian sleep/wake cycle, sleep", "definition": "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. [GOC:go_curators]"}
{"concept_id": "C1154374", "aliases": ["upregulation of circadian sleep/wake cycle, non-REM sleep", "positive regulation of non-REM sleep", "up regulation of circadian sleep/wake cycle, non-REM sleep", "up-regulation of circadian sleep/wake cycle, non-REM sleep"], "types": ["T040"], "canonical_name": "positive regulation of circadian sleep/wake cycle, non-REM sleep", "definition": "Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep. [GOC:go_curators]"}
{"concept_id": "C1154375", "aliases": ["up-regulation of circadian sleep/wake cycle, REM sleep", "positive regulation of REM sleep", "upregulation of circadian sleep/wake cycle, REM sleep", "up regulation of circadian sleep/wake cycle, REM sleep"], "types": ["T040"], "canonical_name": "positive regulation of circadian sleep/wake cycle, REM sleep", "definition": "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep. [GOC:go_curators]"}
{"concept_id": "C1154376", "aliases": ["regulation of non-REM sleep"], "types": ["T040"], "canonical_name": "regulation of circadian sleep/wake cycle, non-REM sleep", "definition": "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. [GOC:go_curators]"}
{"concept_id": "C1154377", "aliases": ["regulation of REM sleep"], "types": ["T040"], "canonical_name": "regulation of circadian sleep/wake cycle, REM sleep", "definition": "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep. [GOC:jl, PMID:11506998]"}
{"concept_id": "C1154378", "aliases": [], "types": ["T040"], "definition": "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours. [GOC:jl, PMID:19708721]", "canonical_name": "ultradian rhythm"}
{"concept_id": "C1154379", "aliases": ["behavioural response to temperature stimulus", "behavioral response to temperature stimulus", "thermosensory behaviour"], "types": ["T055"], "canonical_name": "thermosensory behavior", "definition": "Behavior that is dependent upon the sensation of temperature. [GOC:ems]"}
{"concept_id": "C1154380", "aliases": ["optokinetic behaviour"], "types": ["T055"], "canonical_name": "optokinetic behavior", "definition": "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus. [GOC:jid, GOC:pr]"}
{"concept_id": "C1154381", "aliases": ["behavioural response to pattern orientation", "behavioral response to pattern orientation"], "types": ["T055"], "canonical_name": "pattern orientation", "definition": "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes. [GOC:jid, PMID:9933535]"}
{"concept_id": "C1154383", "aliases": [], "types": ["T043"], "canonical_name": "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "definition": "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. [GOC:hb]"}
{"concept_id": "C1154385", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium-dependent cell-cell adhesion", "definition": "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. [GOC:ai]"}
{"concept_id": "C1154386", "aliases": ["down-regulation of calcium-dependent cell-cell adhesion", "down regulation of calcium-dependent cell-cell adhesion", "downregulation of calcium-dependent cell-cell adhesion"], "types": ["T043"], "canonical_name": "negative regulation of calcium-dependent cell-cell adhesion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion. [GOC:ai]"}
{"concept_id": "C1154387", "aliases": ["up-regulation of calcium-dependent cell-cell adhesion", "up regulation of calcium-dependent cell-cell adhesion", "upregulation of calcium-dependent cell-cell adhesion"], "types": ["T043"], "canonical_name": "positive regulation of calcium-dependent cell-cell adhesion", "definition": "Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion. [GOC:ai]"}
{"concept_id": "C1154388", "aliases": [], "types": ["T043"], "canonical_name": "calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "definition": "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. [GOC:hb]"}
{"concept_id": "C1154393", "aliases": ["leukocyte adhesion", "leukocyte cell adhesion"], "types": ["T043"], "canonical_name": "leukocyte cell-cell adhesion", "definition": "The attachment of a leukocyte to another cell via adhesion molecules. [GOC:go_curators]"}
{"concept_id": "C1154394", "aliases": ["neuron adhesion", "neuronal cell adhesion"], "types": ["T043"], "canonical_name": "neuron cell-cell adhesion", "definition": "The attachment of a neuron to another cell via adhesion molecules. [GOC:go_curators]"}
{"concept_id": "C1154395", "aliases": [], "types": ["T043"], "canonical_name": "homophilic cell adhesion via plasma membrane adhesion molecules", "definition": "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. [ISBN:0198506732]"}
{"concept_id": "C1154396", "aliases": [], "types": ["T043"], "canonical_name": "calcium-dependent cell-matrix adhesion", "definition": "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction. [GOC:hb]"}
{"concept_id": "C1154397", "aliases": [], "types": ["T043"], "canonical_name": "calcium-independent cell-matrix adhesion", "definition": "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction. [GOC:hb]"}
{"concept_id": "C1154398", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell adhesion", "definition": "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. [GOC:mah]"}
{"concept_id": "C1154399", "aliases": ["down-regulation of cell adhesion", "downregulation of cell adhesion", "down regulation of cell adhesion"], "types": ["T043"], "canonical_name": "negative regulation of cell adhesion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. [GOC:go_curators]"}
{"concept_id": "C1154400", "aliases": ["upregulation of cell adhesion", "up regulation of cell adhesion", "up-regulation of cell adhesion"], "types": ["T043"], "canonical_name": "positive regulation of cell adhesion", "definition": "Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators]"}
{"concept_id": "C1154403", "aliases": [], "types": ["T043"], "canonical_name": "axon choice point recognition", "definition": "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth. [PMID:10218152]"}
{"concept_id": "C1154404", "aliases": [], "types": ["T043"], "canonical_name": "axon midline choice point recognition", "definition": "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline. [PMID:11376484]"}
{"concept_id": "C1154405", "aliases": ["motoneuron axon guidance", "motor axon pathfinding", "motor axon guidance"], "types": ["T043"], "canonical_name": "motor neuron axon guidance", "definition": "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. [CL:0000100, GOC:pr, ISBN:0878932437]"}
{"concept_id": "C1154406", "aliases": [], "types": ["T043"], "canonical_name": "regulation of axon extension", "definition": "Any process that modulates the rate, direction or extent of axon extension. [GOC:go_curators]"}
{"concept_id": "C1154407", "aliases": ["downregulation of axon extension", "down-regulation of axon extension", "down regulation of axon extension"], "types": ["T043"], "canonical_name": "negative regulation of axon extension", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. [GOC:mah]"}
{"concept_id": "C1154408", "aliases": ["up regulation of axon extension", "up-regulation of axon extension", "upregulation of axon extension"], "types": ["T043"], "canonical_name": "positive regulation of axon extension", "definition": "Any process that activates or increases the frequency, rate or extent of axon extension. [GOC:go_curators]"}
{"concept_id": "C1154409", "aliases": ["neuronal cell recognition"], "types": ["T043"], "canonical_name": "neuron recognition", "definition": "The process in which a neuronal cell in a multicellular organism interprets its surroundings. [GOC:go_curators]"}
{"concept_id": "C1154410", "aliases": ["neuronal targeting"], "types": ["T043"], "canonical_name": "synaptic target recognition", "definition": "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses. [GOC:mah, ISBN:0878932437]"}
{"concept_id": "C1154411", "aliases": [], "types": ["T043"], "canonical_name": "synaptic target attraction", "definition": "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets. [GOC:mah, ISBN:0878932437]"}
{"concept_id": "C1154412", "aliases": [], "types": ["T043"], "canonical_name": "synaptic target inhibition", "definition": "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source. [GOC:mah, ISBN:0878932437]"}
{"concept_id": "C1154413", "aliases": ["cell-cell signalling"], "types": ["T043"], "definition": "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]", "canonical_name": "cell-cell signaling"}
{"concept_id": "C1154414", "aliases": ["cell fate commitment, cell-cell signalling", "cell-cell signalling resulting in cell fate commitment", "cell-cell signaling during in cell fate commitment", "cell-cell signaling resulting in cell fate commitment", "cell fate commitment, cell-cell signaling", "cell-cell signalling during cell fate commitment"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in cell fate commitment", "definition": "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1154415", "aliases": [], "types": ["T043"], "definition": "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells. [GOC:bf, GOC:kmv]", "canonical_name": "lateral inhibition"}
{"concept_id": "C1154416", "aliases": [], "types": ["T043"], "canonical_name": "peptide hormone secretion", "definition": "The regulated release of a peptide hormone from a cell. [GOC:mah]"}
{"concept_id": "C1154417", "aliases": ["growth hormone secretion"], "types": ["T043"], "definition": "The regulated release of growth hormone from secretory granules into the blood. [GOC:mah]", "canonical_name": "somatotropin secretion"}
{"concept_id": "C1154418", "aliases": ["downregulation of insulin secretion", "down regulation of insulin secretion", "down-regulation of insulin secretion"], "types": ["T043"], "canonical_name": "negative regulation of insulin secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. [GOC:ai]"}
{"concept_id": "C1154419", "aliases": [], "types": ["T043"], "canonical_name": "vasopressin secretion", "definition": "The regulated release of vasopressin from secretory granules into the blood. [GOC:mah]"}
{"concept_id": "C1154421", "aliases": [], "types": ["T043"], "canonical_name": "neuronal action potential propagation", "definition": "The propagation of an action potential along an axon, away from the soma. [GOC:isa_complete]"}
{"concept_id": "C1154422", "aliases": [], "types": ["T043"], "canonical_name": "generation of action potential"}
{"concept_id": "C1154424", "aliases": [], "types": ["T043"], "canonical_name": "ionic insulation of neurons by glial cells"}
{"concept_id": "C1154425", "aliases": ["downregulation of action potential", "down regulation of action potential", "down-regulation of action potential"], "types": ["T043"], "canonical_name": "negative regulation of action potential", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:go_curators]"}
{"concept_id": "C1154426", "aliases": ["upregulation of action potential", "up regulation of action potential", "up-regulation of action potential"], "types": ["T043"], "canonical_name": "positive regulation of action potential", "definition": "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:go_curators]"}
{"concept_id": "C1154427", "aliases": [], "types": ["T043"], "canonical_name": "nerve-nerve synaptic transmission"}
{"concept_id": "C1154428", "aliases": ["acetylcholine breakdown in synaptic cleft", "acetylcholine degradation in synaptic cleft"], "types": ["T043"], "canonical_name": "acetylcholine catabolic process in synaptic cleft", "definition": "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission. [GOC:ai]"}
{"concept_id": "C1154429", "aliases": [], "types": ["T043"], "canonical_name": "neuromuscular synaptic transmission", "definition": "The process of synaptic transmission from a neuron to a muscle, across a synapse. [GOC:dos, GOC:jl, MeSH:D009435]"}
{"concept_id": "C1154430", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neurotransmitter levels", "definition": "Any process that modulates levels of neurotransmitter. [GOC:jl]"}
{"concept_id": "C1154431", "aliases": ["acetylcholine metabolism"], "types": ["T044"], "canonical_name": "acetylcholine metabolic process", "definition": "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. [GOC:jl, GOC:nln, ISBN:0192800752]"}
{"concept_id": "C1154432", "aliases": ["acetylcholine biosynthesis", "acetylcholine synthesis", "acetylcholine anabolism", "acetylcholine formation"], "types": ["T044"], "canonical_name": "acetylcholine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline. [GOC:jl, ISBN:0192800752]"}
{"concept_id": "C1154433", "aliases": ["acetylcholine catabolism", "acetylcholine degradation", "acetylcholine breakdown"], "types": ["T044"], "canonical_name": "acetylcholine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline. [GOC:jl, ISBN:0192800752]"}
{"concept_id": "C1154434", "aliases": ["adrenaline metabolic process", "epinephrine metabolism", "adrenaline metabolism"], "types": ["T044"], "canonical_name": "epinephrine metabolic process", "definition": "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:jl, ISBN:0192801023, ISBN:0198506732]"}
{"concept_id": "C1154435", "aliases": ["epinephrine formation", "epinephrine biosynthesis", "epinephrine anabolism", "adrenaline biosynthetic process", "epinephrine synthesis", "adrenaline biosynthesis"], "types": ["T044"], "canonical_name": "epinephrine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:jl, ISBN:0192801023, ISBN:0198506732]"}
{"concept_id": "C1154436", "aliases": ["epinephrine breakdown", "epinephrine degradation", "adrenaline catabolic process", "epinephrine catabolism", "adrenaline catabolism"], "types": ["T044"], "canonical_name": "epinephrine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:jl, ISBN:0192801023, ISBN:0198506732]"}
{"concept_id": "C1154437", "aliases": ["dopamine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732]", "canonical_name": "dopamine metabolic process"}
{"concept_id": "C1154438", "aliases": ["dopamine anabolism", "dopamine synthesis", "dopamine biosynthesis", "dopamine formation"], "types": ["T044"], "canonical_name": "dopamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154439", "aliases": ["dopamine synthesis from tyrosine", "dopamine formation from tyrosine", "dopamine anabolism from tyrosine"], "types": ["T044"], "canonical_name": "dopamine biosynthetic process from tyrosine", "definition": "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine. [GOC:bf, GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154440", "aliases": ["dopamine breakdown", "dopamine catabolism", "dopamine degradation"], "types": ["T044"], "canonical_name": "dopamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154441", "aliases": ["regulation of dopamine metabolism"], "types": ["T043"], "canonical_name": "regulation of dopamine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. [GOC:go_curators]"}
{"concept_id": "C1154442", "aliases": ["down regulation of dopamine metabolic process", "negative regulation of dopamine metabolism", "downregulation of dopamine metabolic process", "down-regulation of dopamine metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of dopamine metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine. [GOC:go_curators]"}
{"concept_id": "C1154443", "aliases": ["positive regulation of dopamine metabolism", "upregulation of dopamine metabolic process", "up regulation of dopamine metabolic process", "up-regulation of dopamine metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of dopamine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine. [GOC:go_curators]"}
{"concept_id": "C1154444", "aliases": ["histamine metabolism"], "types": ["T044"], "canonical_name": "histamine metabolic process", "definition": "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:jl, ISBN:0395825172]"}
{"concept_id": "C1154445", "aliases": ["histamine formation", "histamine anabolism", "histamine synthesis", "histamine biosynthesis"], "types": ["T044"], "canonical_name": "histamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:jl, ISBN:0395825172]"}
{"concept_id": "C1154447", "aliases": ["levarterenol biosynthesis", "noradrenaline biosynthetic process", "norepinephrine formation", "norepinephrine anabolism", "norepinephrine biosynthesis", "norepinephrine synthesis", "levarterenol biosynthetic process", "noradrenaline biosynthesis"], "types": ["T044"], "canonical_name": "norepinephrine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154448", "aliases": ["octopamine formation", "octopamine synthesis", "octopamine biosynthesis", "octopamine anabolism"], "types": ["T044"], "canonical_name": "octopamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. [ISBN:0198506732]"}
{"concept_id": "C1154449", "aliases": ["phenylethylamine anabolism", "phenylethylamine synthesis", "phenylethylamine formation", "phenylethylamine biosynthesis"], "types": ["T044"], "canonical_name": "phenylethylamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. [GOC:jl, ISBN:0395825172]"}
{"concept_id": "C1154450", "aliases": ["serotonin biosynthesis", "serotonin formation", "serotonin anabolism", "serotonin synthesis"], "types": ["T044"], "canonical_name": "serotonin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154451", "aliases": ["serotonin synthesis from tryptophan", "serotonin formation from tryptophan", "serotonin anabolism from tryptophan"], "types": ["T044"], "canonical_name": "serotonin biosynthetic process from tryptophan", "definition": "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154452", "aliases": [], "types": ["T044"], "canonical_name": "tryptophan hydroxylase activation"}
{"concept_id": "C1154453", "aliases": ["neurotransmitter catabolism", "neurotransmitter degradation", "neurotransmitter breakdown"], "types": ["T043"], "canonical_name": "neurotransmitter catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. [GOC:jl]"}
{"concept_id": "C1154454", "aliases": ["norepinephrine degradation", "levarterenol catabolism", "levarterenol catabolic process", "noradrenaline catabolic process", "norepinephrine breakdown", "norepinephrine catabolism", "noradrenaline catabolism"], "types": ["T044"], "canonical_name": "norepinephrine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154455", "aliases": ["octopamine degradation", "octopamine catabolism", "octopamine breakdown"], "types": ["T044"], "canonical_name": "octopamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. [ISBN:0198506732]"}
{"concept_id": "C1154456", "aliases": ["phenylethylamine degradation", "phenylethylamine breakdown", "phenylethylamine catabolism"], "types": ["T044"], "canonical_name": "phenylethylamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. [GOC:jl, ISBN:0395825172]"}
{"concept_id": "C1154458", "aliases": ["noradrenaline metabolic process", "levarterenol metabolism", "norepinephrine metabolism", "noradrenaline metabolism", "levarterenol metabolic process"], "types": ["T044"], "canonical_name": "norepinephrine metabolic process", "definition": "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154459", "aliases": ["octopamine metabolism"], "types": ["T044"], "canonical_name": "octopamine metabolic process", "definition": "The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. [ISBN:0198506732]"}
{"concept_id": "C1154460", "aliases": ["phenylethylamine metabolism"], "types": ["T044"], "canonical_name": "phenylethylamine metabolic process", "definition": "The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. [GOC:jl, ISBN:0395825172]"}
{"concept_id": "C1154461", "aliases": ["serotonin metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:jl, ISBN:0198506732]", "canonical_name": "serotonin metabolism"}
{"concept_id": "C1154462", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle endocytosis", "definition": "A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]"}
{"concept_id": "C1154464", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle coating", "definition": "The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles. [GOC:curators, PMID:10099709, PMID:20448150]"}
{"concept_id": "C1154465", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle fission", "definition": "OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane. [GOC:curators]"}
{"concept_id": "C1154467", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle maturation", "definition": "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle. [GOC:curators, PMID:10099709]"}
{"concept_id": "C1154468", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle retrieval", "definition": "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane. [GOC:curators]"}
{"concept_id": "C1154469", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle to endosome fusion", "definition": "Fusion of a synaptic vesicle with an endosome. [GOC:curators, PMID:10099709]"}
{"concept_id": "C1154470", "aliases": ["synaptic vesicle coat protein depolymerization", "synaptic vesicle coat depolymerization"], "types": ["T043"], "canonical_name": "synaptic vesicle uncoating", "definition": "The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane. [GOC:curators, PMID:10099709, PMID:24596248]"}
{"concept_id": "C1154471", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle exocytosis", "definition": "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. [GOC:jid, GOC:lmg]"}
{"concept_id": "C1154472", "aliases": ["synaptic vesicle budding involved in synaptic vesicle exocytosis", "endosome to synaptic vesicle budding"], "types": ["T043"], "canonical_name": "synaptic vesicle budding from endosome", "definition": "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes. [GOC:curators, PMID:10099709, PMID:24596248]"}
{"concept_id": "C1154474", "aliases": ["synaptic vesicle fusion"], "types": ["T043"], "canonical_name": "synaptic vesicle fusion", "definition": "OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane. [GOC:curators]"}
{"concept_id": "C1154475", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle priming", "definition": "A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. [GOC:mah, PMID:15217342, PMID:23060190]"}
{"concept_id": "C1154476", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle targeting", "definition": "The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces. [GOC:mah]"}
{"concept_id": "C1154477", "aliases": ["neurotransmitter storage", "neurotransmitter sequestration", "sequestration of neurotransmitter", "retention of neurotransmitter", "storage of neurotransmitter", "neurotransmitter retention"], "types": ["T043"], "canonical_name": "sequestering of neurotransmitter", "definition": "The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system. [GOC:ai]"}
{"concept_id": "C1154479", "aliases": ["neurotransmitter receptor metabolism"], "types": ["T044"], "canonical_name": "neurotransmitter receptor metabolic process", "definition": "The chemical reactions and pathways involving neurotransmitter receptors. [GOC:go_curators]"}
{"concept_id": "C1154481", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle transport", "definition": "The directed movement of synaptic vesicles. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr]"}
{"concept_id": "C1154484", "aliases": ["active induction of host immune response by virus"], "types": ["T043"], "canonical_name": "active viral induction of host immune response"}
{"concept_id": "C1154488", "aliases": ["passive activation of host immune response by virus", "passive induction of host immune response by virus"], "types": ["T043"], "canonical_name": "passive viral induction of host immune response"}
{"concept_id": "C1154492", "aliases": ["viral host defense evasion", "viral host defence evasion"], "types": ["T043"], "canonical_name": "evasion of host defenses by virus"}
{"concept_id": "C1154494", "aliases": ["suppression by virus of host apoptosis", "suppression of apoptosis in host by virus", "negative regulation by virus of host apoptosis", "negative regulation of apoptosis by virus"], "types": ["T046"], "canonical_name": "suppression by virus of host apoptotic process", "definition": "Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication. [GOC:mtg_apoptosis, ISBN:0781718325]"}
{"concept_id": "C1154497", "aliases": ["viral inhibition of termination of host cell protein biosynthetic process", "viral suppression of termination by host of host cell protein biosynthetic process", "viral inhibition of host cell protein biosynthesis shutoff", "negative regulation by virus of host cell protein biosynthesis shutoff", "viral suppression of termination by host of host cell protein biosynthesis", "suppression by virus of host termination of protein biosynthetic process", "negative regulation by virus of host cell protein biosynthetic process shutoff", "viral inhibition of host cell protein biosynthetic process shutoff", "viral inhibition of termination of host cell protein biosynthesis"], "types": ["T046"], "canonical_name": "suppression by virus of host translation termination", "definition": "Any viral process that stops, prevents, or reduces the frequency, rate or extent of translational termination of a host mRNA. [ISBN:0781718325]"}
{"concept_id": "C1154499", "aliases": ["negative regulation by virus of host cytokine production"], "types": ["T046"], "canonical_name": "suppression by virus of host cytokine production", "definition": "Any viral process that results in the inhibition of host cell cytokine production. [PMID:10859382]"}
{"concept_id": "C1154500", "aliases": ["suppression by virus of intracellular interferon activity in host", "negative regulation by virus of intracellular interferon activity"], "types": ["T046"], "canonical_name": "suppression by virus of host intracellular interferon activity", "definition": "Any viral process that results in the inhibition of interferon activity within the host cell. [PMID:10859382]"}
{"concept_id": "C1154501", "aliases": ["suppression by virus of host MHC class I cell surface presentation", "negative regulation by virus of MHC class I cell surface presentation", "suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I", "suppression by virus of MHC class I cell surface presentation in host"], "types": ["T046"], "definition": "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response. [GOC:add, GOC:bf, PMID:10859382]", "canonical_name": "inhibition of host MHC class I molecule presentation by virus"}
{"concept_id": "C1154502", "aliases": ["modulation by virus of host cellular process", "modulation by virus of host process", "modification by virus of host cellular process", "regulation of cellular process in host by virus", "viral host cell process manipulation", "regulation by virus of host cellular process", "modulation of cellular process in host by virus"], "types": ["T043"], "definition": "The process in which a virus effects a change in the processes and activities of its host organism. [GOC:jl]", "canonical_name": "regulation of host cellular process by virus"}
{"concept_id": "C1154503", "aliases": ["viral perturbation of cell cycle regulation"], "types": ["T043"], "canonical_name": "modification by virus of host cell cycle regulation", "definition": "Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication. [GOC:dph, ISBN:0781718325]"}
{"concept_id": "C1154504", "aliases": ["negative regulation by virus of cell cycle arrest", "viral inhibition of cell cycle arrest"], "types": ["T046"], "canonical_name": "suppression by virus of host cell cycle arrest", "definition": "Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur. [PMID:9371605]"}
{"concept_id": "C1154505", "aliases": ["regulation of translation in host by virus", "regulation of host mRNA translation by virus", "modulation of host translation by virus", "regulation of host translation by virus", "modification by virus of host cell mRNA translation", "viral perturbation of host cell mRNA translation"], "types": ["T046"], "canonical_name": "modulation by virus of host translation", "definition": "Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA. [ISBN:0781718325]"}
{"concept_id": "C1154506", "aliases": ["viral perturbation of polysomes"], "types": ["T043"], "canonical_name": "modification by virus of host polysomes", "definition": "Any viral process that interferes with and inhibits the assembly and function of polysomes. [PMID:10438802]"}
{"concept_id": "C1154507", "aliases": ["viral perturbation of host cell transcription", "modification by virus of host transcription"], "types": ["T043"], "canonical_name": "modulation by virus of host transcription", "definition": "Any process in which a virus modulates the frequency, rate or extent of its host's transcription. [ISBN:0781718325]"}
{"concept_id": "C1154509", "aliases": ["viral perturbation of host mRNA processing"], "types": ["T045"], "canonical_name": "modification by virus of host mRNA processing", "definition": "Any viral process that interferes with the processing of mRNA in the host cell. [ISBN:0781718325]"}
{"concept_id": "C1154511", "aliases": ["viral inhibition of host mRNA splicing", "viral dispersion of host splicing factors", "suppression by virus of host splicing factor activity", "negative regulation by virus of host mRNA splicing"], "types": ["T045"], "canonical_name": "suppression by virus of host mRNA splicing", "definition": "Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production. [ISBN:0781718325, PMID:19729513]"}
{"concept_id": "C1154512", "aliases": ["virus-induced modification of host RNA polymerase II", "induction by virus of modification of host RNA polymerase II"], "types": ["T043"], "canonical_name": "induction by virus of phosphorylation of host RNA polymerase II", "definition": "Any process in which a virus activates the frequency, rate or extent of phosphorylation of host RNA polymerase II. [PMID:7637000]"}
{"concept_id": "C1154513", "aliases": ["pollen-gynoecium interaction"], "types": ["T043"], "canonical_name": "pollen-pistil interaction", "definition": "The interaction between a pollen grain and pistil. [PMID:27899537]"}
{"concept_id": "C1154515", "aliases": [], "types": ["T043"], "canonical_name": "pollen adhesion", "definition": "The process in which pollen deposited on the stigma adheres to cells of the stigma. [GOC:tair_curators]"}
{"concept_id": "C1154516", "aliases": [], "types": ["T043"], "canonical_name": "pollen hydration", "definition": "The process in which water is taken up by pollen. [GOC:lr]"}
{"concept_id": "C1154517", "aliases": ["pollen recognition"], "types": ["T043"], "canonical_name": "recognition of pollen", "definition": "A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma. [GOC:dph, GOC:pj, GOC:tb]"}
{"concept_id": "C1154518", "aliases": [], "types": ["T043"], "canonical_name": "pollen tube adhesion", "definition": "The process in which the pollen tube adheres to cells of the stigma and style. [GOC:tair_curators, PMID:12602877]"}
{"concept_id": "C1154522", "aliases": [], "types": ["T043"], "canonical_name": "response to endogenous stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. [GOC:sm]"}
{"concept_id": "C1154523", "aliases": ["perception of endogenous stimulus"], "types": ["T043"], "canonical_name": "detection of endogenous stimulus", "definition": "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154524", "aliases": ["perception of carbohydrate stimulus"], "types": ["T043"], "canonical_name": "detection of carbohydrate stimulus", "definition": "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154525", "aliases": ["perception of hexose stimulus"], "types": ["T043"], "canonical_name": "detection of hexose stimulus", "definition": "The series of events in which a stimulus from a hexose is received and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154526", "aliases": ["perception of sucrose stimulus"], "types": ["T043"], "canonical_name": "detection of sucrose stimulus", "definition": "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154527", "aliases": ["perception of hormone stimulus"], "types": ["T043"], "canonical_name": "detection of hormone stimulus", "definition": "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154528", "aliases": ["perception of abscisic acid stimulus"], "types": ["T043"], "canonical_name": "detection of abscisic acid stimulus", "definition": "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154529", "aliases": ["perception of auxin stimulus"], "types": ["T043"], "canonical_name": "detection of auxin stimulus", "definition": "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154530", "aliases": ["perception of brassinosteroid stimulus"], "types": ["T043"], "canonical_name": "detection of brassinosteroid stimulus", "definition": "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154531", "aliases": ["perception of cytokinin stimulus"], "types": ["T043"], "canonical_name": "detection of cytokinin stimulus", "definition": "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154532", "aliases": ["detection of ethene stimulus", "perception of ethene stimulus", "perception of ethylene stimulus"], "types": ["T043"], "canonical_name": "detection of ethylene stimulus", "definition": "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154533", "aliases": ["perception of gibberellic acid stimulus"], "types": ["T043"], "canonical_name": "detection of gibberellic acid stimulus", "definition": "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154534", "aliases": ["response to carbohydrate stimulus"], "types": ["T043"], "canonical_name": "response to carbohydrate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. [GOC:jl]"}
{"concept_id": "C1154535", "aliases": ["carbohydrate mediated signalling"], "types": ["T044"], "canonical_name": "carbohydrate mediated signaling", "definition": "The series of molecular signals mediated by the detection of carbohydrate. [GOC:sm]"}
{"concept_id": "C1154536", "aliases": ["hexose mediated signalling"], "types": ["T044"], "canonical_name": "hexose mediated signaling", "definition": "The series of molecular signals mediated by the detection of hexose. [GOC:sm]"}
{"concept_id": "C1154537", "aliases": ["hexokinase-dependent signalling"], "types": ["T044"], "canonical_name": "hexokinase-dependent signaling", "definition": "The series of molecular signals mediated by hexose and dependent on the detection of hexokinase. [GOC:mah, GOC:sm]"}
{"concept_id": "C1154538", "aliases": ["hexokinase-independent signalling"], "types": ["T044"], "canonical_name": "hexokinase-independent signaling", "definition": "The series of molecular signals mediated by hexose and independent of hexokinase. [GOC:mah, GOC:sm]"}
{"concept_id": "C1154539", "aliases": ["sucrose mediated signalling"], "types": ["T044"], "canonical_name": "sucrose mediated signaling", "definition": "The series of molecular signals mediated by the detection of sucrose. [GOC:sm]"}
{"concept_id": "C1154540", "aliases": ["response to hexose stimulus"], "types": ["T043"], "canonical_name": "response to hexose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. [GOC:jl]"}
{"concept_id": "C1154541", "aliases": ["response to fructose stimulus"], "types": ["T043"], "canonical_name": "response to fructose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. [GOC:jl]"}
{"concept_id": "C1154542", "aliases": ["response to glucose stimulus"], "types": ["T043"], "canonical_name": "response to glucose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:jl]"}
{"concept_id": "C1154543", "aliases": ["response to sucrose stimulus"], "types": ["T043"], "canonical_name": "response to sucrose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus. [GOC:jl]"}
{"concept_id": "C1154544", "aliases": ["response to hormone stimulus"], "types": ["T043"], "canonical_name": "response to hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:jl]"}
{"concept_id": "C1154545", "aliases": ["hormone mediated signalling"], "types": ["T044"], "canonical_name": "hormone-mediated signaling pathway", "definition": "The series of molecular signals mediated by the detection of a hormone. [GOC:sm]"}
{"concept_id": "C1154546", "aliases": ["abscisic acid-mediated signaling pathway", "ABA signal transduction", "abscisic acid mediated signalling", "ABA signaling"], "types": ["T044"], "canonical_name": "abscisic acid-activated signaling pathway", "definition": "The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription. [GOC:signaling, GOC:sm, PMID:24269821]"}
{"concept_id": "C1154547", "aliases": ["regulation of abscisic acid mediated signalling", "regulation of abscisic acid mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of abscisic acid-activated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling. [GOC:lr]"}
{"concept_id": "C1154548", "aliases": ["down regulation of abscisic acid mediated signaling", "down-regulation of abscisic acid mediated signaling", "negative regulation of abscisic acid mediated signalling", "negative regulation of abscisic acid mediated signaling pathway", "downregulation of abscisic acid mediated signaling"], "types": ["T044"], "canonical_name": "negative regulation of abscisic acid-activated signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling. [GOC:lr]"}
{"concept_id": "C1154549", "aliases": ["up-regulation of abscisic acid mediated signaling", "positive regulation of abscisic acid mediated signalling", "up regulation of abscisic acid mediated signaling", "positive regulation of abscisic acid mediated signaling pathway", "upregulation of abscisic acid mediated signaling"], "types": ["T044"], "canonical_name": "positive regulation of abscisic acid-activated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling. [GOC:lr]"}
{"concept_id": "C1154550", "aliases": ["auxin signal transduction", "auxin mediated signaling pathway", "auxin mediated signalling", "auxin signaling"], "types": ["T044"], "canonical_name": "auxin-activated signaling pathway", "definition": "The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:sm, PMID:16990790, PMID:18647826]"}
{"concept_id": "C1154551", "aliases": ["brassinosteroid mediated signalling"], "types": ["T044"], "canonical_name": "brassinosteroid mediated signaling pathway", "definition": "The series of molecular signals mediated by the detection of brassinosteroid. [GOC:sm]"}
{"concept_id": "C1154552", "aliases": ["cytokinin mediated signalling", "cytokinin signaling", "cytokinin mediated signaling pathway"], "types": ["T044"], "canonical_name": "cytokinin-activated signaling pathway", "definition": "The series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:sm, PMID:24080474]"}
{"concept_id": "C1154553", "aliases": ["ethene mediated signaling pathway", "ethylene mediated signaling pathway", "ethene mediated signalling pathway", "ethylene mediated signalling pathway"], "types": ["T044"], "canonical_name": "ethylene-activated signaling pathway", "definition": "The series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription. [GOC:jy, PMID:24012247]"}
{"concept_id": "C1154554", "aliases": ["ethene mediated signaling pathway (induced systemic resistance)", "induced systemic resistance, ethylene mediated signalling pathway", "induced systemic resistance, ethene mediated signalling pathway", "ethylene mediated signaling pathway (induced systemic resistance)", "induced systemic resistance, ethene mediated signaling pathway"], "types": ["T044"], "canonical_name": "induced systemic resistance, ethylene mediated signaling pathway", "definition": "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance. [GOC:jy]"}
{"concept_id": "C1154555", "aliases": ["jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway", "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway", "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway", "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway", "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)", "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)", "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway"], "types": ["T044"], "canonical_name": "jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway", "definition": "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance. [GOC:jy]"}
{"concept_id": "C1154556", "aliases": ["gibberellic acid mediated signalling", "gibberellic acid signaling", "GA-signaling"], "types": ["T044"], "canonical_name": "gibberellic acid mediated signaling pathway", "definition": "The series of molecular signals mediated by the detection of gibberellic acid. [GOC:sm]"}
{"concept_id": "C1154557", "aliases": ["gibberellic acid mediated signalling, G-alpha-dependent"], "types": ["T044"], "canonical_name": "gibberellic acid mediated signaling pathway, G-alpha-dependent", "definition": "The series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors. [GOC:pj, PMID:11027362]"}
{"concept_id": "C1154558", "aliases": ["gibberellic acid mediated signalling, G-alpha-independent"], "types": ["T044"], "canonical_name": "gibberellic acid mediated signaling pathway, G-alpha-independent", "definition": "The series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors. [GOC:pj, PMID:11027362]"}
{"concept_id": "C1154559", "aliases": ["regulation of gibberellic acid mediated signalling"], "types": ["T044"], "canonical_name": "regulation of gibberellic acid mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling. [GOC:go_curators]"}
{"concept_id": "C1154560", "aliases": ["negative regulation of gibberellic acid mediated signalling", "down-regulation of gibberellic acid mediated signaling", "downregulation of gibberellic acid mediated signaling", "down regulation of gibberellic acid mediated signaling"], "types": ["T044"], "canonical_name": "negative regulation of gibberellic acid mediated signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity. [GOC:sm]"}
{"concept_id": "C1154561", "aliases": ["up-regulation of gibberellic acid mediated signaling", "up regulation of gibberellic acid mediated signaling", "positive regulation of gibberellic acid mediated signalling", "upregulation of gibberellic acid mediated signaling"], "types": ["T044"], "canonical_name": "positive regulation of gibberellic acid mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity. [GOC:sm]"}
{"concept_id": "C1154562", "aliases": ["response to abscisic acid stimulus"], "types": ["T043"], "canonical_name": "response to abscisic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. [GOC:jl]"}
{"concept_id": "C1154563", "aliases": ["response to auxin stimulus"], "types": ["T043"], "canonical_name": "response to auxin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. [GOC:jl]"}
{"concept_id": "C1154564", "aliases": ["response to brassinosteroid stimulus"], "types": ["T043"], "canonical_name": "response to brassinosteroid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus. [GOC:jl]"}
{"concept_id": "C1154565", "aliases": ["response to cytokinin stimulus"], "types": ["T043"], "canonical_name": "response to cytokinin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus. [GOC:jl]"}
{"concept_id": "C1154566", "aliases": ["response to ethylene stimulus", "response to ethene stimulus"], "types": ["T043"], "canonical_name": "response to ethylene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. [GOC:jl]"}
{"concept_id": "C1154567", "aliases": ["response to gibberellin stimulus", "response to gibberellic acid stimulus"], "types": ["T043"], "canonical_name": "response to gibberellin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus. [GOC:jl]"}
{"concept_id": "C1154568", "aliases": ["response to jasmonic acid stimulus"], "types": ["T043"], "canonical_name": "response to jasmonic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. [GOC:jl]"}
{"concept_id": "C1154569", "aliases": ["JA signaling", "jasmonic acid mediated signalling pathway"], "types": ["T044"], "canonical_name": "jasmonic acid mediated signaling pathway", "definition": "The series of molecular signals mediated by jasmonic acid. [GOC:jy, PMID:16478936, PMID:19522558, PMID:20159850]"}
{"concept_id": "C1154570", "aliases": ["jasmonic acid mediated signaling pathway (induced systemic resistance)", "induced systemic resistance, jasmonic acid mediated signalling pathway"], "types": ["T044"], "canonical_name": "induced systemic resistance, jasmonic acid mediated signaling pathway", "definition": "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance. [GOC:jy]"}
{"concept_id": "C1154571", "aliases": ["jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway", "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway", "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway", "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)", "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)", "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway", "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway"], "types": ["T044"], "canonical_name": "jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway", "definition": "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance. [GOC:jy]"}
{"concept_id": "C1154572", "aliases": ["perception of jasmonic acid stimulus"], "types": ["T043"], "canonical_name": "detection of jasmonic acid stimulus", "definition": "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule. [GOC:sm]"}
{"concept_id": "C1154573", "aliases": ["response to salicylic acid stimulus", "response to salicylate"], "types": ["T043"], "canonical_name": "response to salicylic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. [GOC:jl]"}
{"concept_id": "C1154574", "aliases": ["perception of salicylic acid stimulus"], "types": ["T043"], "canonical_name": "detection of salicylic acid stimulus", "definition": "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1154575", "aliases": ["salicylic acid mediated signalling pathway", "salicylic acid mediated signal transduction", "salicylic acid-mediated signaling pathway"], "types": ["T044"], "canonical_name": "salicylic acid mediated signaling pathway", "definition": "The series of molecular signals mediated by salicylic acid. [GOC:jy]"}
{"concept_id": "C1154576", "aliases": ["systemic acquired resistance, salicylic acid mediated signalling pathway", "salicylic acid mediated signaling pathway (systemic acquired resistance)"], "types": ["T044"], "canonical_name": "systemic acquired resistance, salicylic acid mediated signaling pathway", "definition": "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance. [GOC:jy]"}
{"concept_id": "C1154577", "aliases": ["response to environmental stimulus"], "types": ["T038"], "canonical_name": "response to external stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. [GOC:hb]"}
{"concept_id": "C1154578", "aliases": [], "types": ["T045"], "canonical_name": "DNA protection", "definition": "Any process in which DNA is protected from damage by, for example, oxidative stress. [GOC:jl]"}
{"concept_id": "C1154579", "aliases": ["regulation of growth by external stimulus", "regulation of growth by external stimuli", "regulation of cell growth by sensing of exogenous stimulus", "regulation of growth by exogenous signal", "regulation of growth by external signal", "regulation of growth by exogenous stimuli", "regulation of cell growth by detection of exogenous stimulus", "regulation of growth by exogenous stimulus", "interpretation of external signals that regulate cell growth"], "types": ["T043"], "canonical_name": "regulation of cell growth by extracellular stimulus", "definition": "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time. [GOC:dph]"}
{"concept_id": "C1154580", "aliases": [], "types": ["T043"], "canonical_name": "chemokinesis", "definition": "A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis). [GOC:jl, PMID:2073411]"}
{"concept_id": "C1154581", "aliases": [], "types": ["T040"], "canonical_name": "klinokinesis", "definition": "The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered. [GOC:jl, PMID:2790068]"}
{"concept_id": "C1154582", "aliases": [], "types": ["T040"], "canonical_name": "orthokinesis", "definition": "The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased. [GOC:jl, PMID:8207088]"}
{"concept_id": "C1154583", "aliases": ["perception of external stimulus"], "types": ["T043"], "canonical_name": "detection of external stimulus", "definition": "The series of events in which an external stimulus is received by a cell and converted into a molecular signal. [GOC:hb]"}
{"concept_id": "C1154584", "aliases": ["perception of abiotic stimulus"], "types": ["T043"], "canonical_name": "detection of abiotic stimulus", "definition": "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. [GOC:hb]"}
{"concept_id": "C1154585", "aliases": ["perception of chemical stimulus", "detection of chemical substance", "perception of chemical substance", "chemoperception"], "types": ["T043"], "canonical_name": "detection of chemical stimulus", "definition": "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. [GOC:jl]"}
{"concept_id": "C1154586", "aliases": ["chemosensory perception"], "types": ["T043"], "canonical_name": "sensory perception of chemical stimulus", "definition": "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]"}
{"concept_id": "C1154587", "aliases": ["detection of Ca2+ ion", "calcium ion detection", "calcium ion sensing", "Ca2+ ion detection"], "types": ["T043"], "canonical_name": "detection of calcium ion", "definition": "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. [GOC:pg]"}
{"concept_id": "C1154588", "aliases": ["pheromone response"], "types": ["T043"], "canonical_name": "response to pheromone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. [GOC:jl]"}
{"concept_id": "C1154590", "aliases": [], "types": ["T043"], "canonical_name": "re-entry into mitotic cell cycle after pheromone arrest", "definition": "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae. [GOC:krc, PMID:9927449]"}
{"concept_id": "C1154591", "aliases": ["adaptation to pheromone involved conjugation without cellular fusion", "desensitization to pheromone during conjugation without cellular fusion"], "types": ["T043"], "canonical_name": "adaptation to pheromone regulating conjugation with mutual genetic exchange", "definition": "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. [GOC:clt]"}
{"concept_id": "C1154599", "aliases": ["quorum sensing"], "types": ["T043"], "definition": "A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.", "canonical_name": "quorum sensing system"}
{"concept_id": "C1154602", "aliases": [], "types": ["T043"], "canonical_name": "cell cycle arrest in response to pheromone"}
{"concept_id": "C1154603", "aliases": ["shmooing"], "types": ["T043"], "canonical_name": "shmooing"}
{"concept_id": "C1154608", "aliases": [], "types": ["T043"], "canonical_name": "response to pheromone regulating pheromone-induced unidirectional conjugation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation. [GOC:clt]"}
{"concept_id": "C1154610", "aliases": ["bitter taste perception"], "types": ["T040"], "canonical_name": "sensory perception of bitter taste", "definition": "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]"}
{"concept_id": "C1154611", "aliases": ["salty taste perception"], "types": ["T040"], "canonical_name": "sensory perception of salty taste", "definition": "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]"}
{"concept_id": "C1154612", "aliases": ["sour taste perception"], "types": ["T040"], "canonical_name": "sensory perception of sour taste", "definition": "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]"}
{"concept_id": "C1154613", "aliases": ["sweet taste perception"], "types": ["T040"], "definition": "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]", "canonical_name": "sensory perception of sweet taste"}
{"concept_id": "C1154614", "aliases": ["umami taste perception"], "types": ["T043"], "canonical_name": "sensory perception of umami taste", "definition": "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process. [GOC:ai]"}
{"concept_id": "C1154615", "aliases": ["detection of nutrients", "nutrient sensing", "perception of nutrients"], "types": ["T043"], "canonical_name": "detection of nutrient", "definition": "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal. [GOC:jl]"}
{"concept_id": "C1154616", "aliases": ["detection of light", "perception of light"], "types": ["T043"], "canonical_name": "detection of light stimulus", "definition": "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. [GOC:go_curators]"}
{"concept_id": "C1154617", "aliases": [], "types": ["T044"], "canonical_name": "absorption of UV light", "definition": "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1154618", "aliases": [], "types": ["T044"], "canonical_name": "absorption of visible light", "definition": "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1154619", "aliases": ["detection of ultraviolet radiation stimulus", "detection of ultraviolet light stimulus", "perception of UV", "detection of UV radiation stimulus", "detection of UV light stimulus"], "types": ["T043"], "canonical_name": "detection of UV", "definition": "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732]"}
{"concept_id": "C1154620", "aliases": ["phototransduction, ultraviolet light", "phototransduction, UV light", "phototransduction, ultraviolet radiation", "phototransduction, UV radiation"], "types": ["T043"], "canonical_name": "phototransduction, UV", "definition": "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1154621", "aliases": ["perception of visible light"], "types": ["T043"], "canonical_name": "detection of visible light", "definition": "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1154623", "aliases": [], "types": ["T043"], "canonical_name": "red, far-red light phototransduction", "definition": "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. [GOC:mah]"}
{"concept_id": "C1154625", "aliases": ["adaptation of rhodopsin mediated signalling"], "types": ["T043"], "canonical_name": "adaptation of rhodopsin mediated signaling", "definition": "The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation. [PMID:1962207]"}
{"concept_id": "C1154626", "aliases": ["deactivation of rhodopsin mediated signalling"], "types": ["T043"], "canonical_name": "deactivation of rhodopsin mediated signaling", "definition": "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon). [PMID:8316831]"}
{"concept_id": "C1154627", "aliases": [], "types": ["T044"], "canonical_name": "metarhodopsin inactivation", "definition": "The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it. [GOC:hb, Wikipedia:Visual_phototransduction]"}
{"concept_id": "C1154628", "aliases": [], "types": ["T043"], "canonical_name": "regulation of light-activated channel activity", "definition": "Any process that modulates the frequency, rate or extent of light-activated channel activity. [GOC:go_curators]"}
{"concept_id": "C1154629", "aliases": ["downregulation of light-activated channel activity", "down-regulation of light-activated channel activity", "down regulation of light-activated channel activity"], "types": ["T043"], "canonical_name": "negative regulation of light-activated channel activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity. [GOC:go_curators]"}
{"concept_id": "C1154630", "aliases": ["up regulation of light-activated channel activity", "up-regulation of light-activated channel activity", "upregulation of light-activated channel activity"], "types": ["T043"], "canonical_name": "positive regulation of light-activated channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of light-activated channel activity. [GOC:go_curators]"}
{"concept_id": "C1154631", "aliases": ["light-induced release of internally sequestered calcium ion (Ca2+)", "light-induced release of calcium from internal store", "light-induced release of internally stored calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "light-induced release of internally sequestered calcium ion", "definition": "The process in which the detection of light triggers the release of internally sequestered calcium ions. [GOC:ai]"}
{"concept_id": "C1154633", "aliases": ["changes in polarization state of photoreceptor cell membrane"], "types": ["T043"], "canonical_name": "regulation of membrane potential in photoreceptor cell", "definition": "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. [GOC:dph, GOC:hb, GOC:tb]"}
{"concept_id": "C1154634", "aliases": ["maintenance of rhodopsin mediated signalling", "maintenance of rhodopsin mediated signaling"], "types": ["T043"], "canonical_name": "maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling", "definition": "Maintenance of the excited state of a photoreceptor cell to produce a steady-state current as a result of signals generated by rhodopsin activation by a photon. [GOC:dph, GOC:hb, GOC:tb]"}
{"concept_id": "C1154635", "aliases": ["rhodopsin mediated G-protein signaling, coupled to IP3 second messenger", "rhodopsin mediated G protein signaling, coupled to IP3 second messenger", "PLC-activating rhodopsin mediated signaling pathway", "phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway", "rhodopsin mediated G protein signalling, coupled to IP3 second messenger", "rhodopsin mediated G-protein signalling, coupled to IP3 second messenger"], "types": ["T044"], "canonical_name": "phospholipase C-activating rhodopsin mediated signaling pathway", "definition": "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by a rhodopsin molecule being activated by a photon, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931]"}
{"concept_id": "C1154636", "aliases": [], "types": ["T043"], "canonical_name": "UV-A, blue light phototransduction", "definition": "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm. [GOC:mah]"}
{"concept_id": "C1154637", "aliases": [], "types": ["T043"], "canonical_name": "photoreceptor cell maintenance", "definition": "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. [CL:0000210, GOC:bf, GOC:rl]"}
{"concept_id": "C1154640", "aliases": ["perception of biotic stimulus"], "types": ["T043"], "canonical_name": "detection of biotic stimulus", "definition": "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. [GOC:hb]"}
{"concept_id": "C1154642", "aliases": ["perception of bacterium", "perception of bacteria", "detection of bacteria"], "types": ["T043"], "definition": "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal. [GOC:hb]", "canonical_name": "detection of bacterium"}
{"concept_id": "C1154645", "aliases": ["detection of BLP", "perception of BLP", "perception of bacterial lipoprotein"], "types": ["T043"], "canonical_name": "detection of bacterial lipoprotein", "definition": "The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs). [GOC:jl, PMID:12077222]"}
{"concept_id": "C1154646", "aliases": ["detection of diacylated bacterial lipoprotein", "perception of diacylated bacterial lipoprotein"], "types": ["T043"], "canonical_name": "detection of diacyl bacterial lipopeptide", "definition": "The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]"}
{"concept_id": "C1154647", "aliases": ["perception of triacylated bacterial lipoprotein", "detection of triacylated bacterial lipoprotein"], "types": ["T043"], "canonical_name": "detection of triacyl bacterial lipopeptide", "definition": "The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]"}
{"concept_id": "C1154648", "aliases": ["detection of symbiotic bacteria", "perception of symbiotic bacterium", "perception of symbiotic bacteria"], "types": ["T040"], "canonical_name": "detection of symbiotic bacterium", "definition": "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal. [GOC:hb, ISBN:0198506732]"}
{"concept_id": "C1154649", "aliases": ["detection of fungus", "perception of fungus", "detection of fungi"], "types": ["T043"], "definition": "The series of events in which a stimulus from a fungus is received and converted into a molecular signal. [GOC:hb]", "canonical_name": "perception of fungi"}
{"concept_id": "C1154650", "aliases": ["detection of parasitic fungus"], "types": ["T040"], "canonical_name": "detection of parasitic fungi"}
{"concept_id": "C1154652", "aliases": ["perception of symbiotic fungus", "perception of symbiotic fungi", "detection of symbiotic fungi"], "types": ["T040"], "canonical_name": "detection of symbiotic fungus", "definition": "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal. [GOC:hb, ISBN:0198506732]"}
{"concept_id": "C1154653", "aliases": ["perception of insect"], "types": ["T040"], "canonical_name": "detection of insect", "definition": "The series of events in which a stimulus from an insect is received and converted into a molecular signal. [GOC:hb]"}
{"concept_id": "C1154654", "aliases": ["perception of nematode"], "types": ["T043"], "canonical_name": "detection of nematode", "definition": "The series of events in which a stimulus from a nematode is received and converted into a molecular signal. [GOC:hb]"}
{"concept_id": "C1154655", "aliases": ["detection of protozoa", "perception of protozoa", "detection of protozoon"], "types": ["T043"], "canonical_name": "detection of protozoan", "definition": "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal. [GOC:ai]"}
{"concept_id": "C1154656", "aliases": ["recognition of symbiont", "perception of symbiont"], "types": ["T040"], "canonical_name": "detection of symbiont", "definition": "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:hb, ISBN:0198506732]"}
{"concept_id": "C1154657", "aliases": ["detection of virus"], "types": ["T043"], "definition": "The series of events in which a stimulus from a virus is received and converted into a molecular signal. [GOC:hb]", "canonical_name": "perception of virus"}
{"concept_id": "C1154660", "aliases": [], "types": ["T040"], "canonical_name": "perception of static position", "definition": "The perception of the orientation of different parts of the body with respect to one another. [ISBN:072168677X]"}
{"concept_id": "C1154661", "aliases": [], "types": ["T040"], "canonical_name": "response to abiotic stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. [GOC:hb]"}
{"concept_id": "C1154662", "aliases": ["response to chemical substance", "response to chemical stimulus"], "types": ["T043"], "canonical_name": "response to chemical", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. [GOC:jl]"}
{"concept_id": "C1154663", "aliases": ["initiation of acetate breakdown by acetate", "initiation of acetate degradation by acetate"], "types": ["T043"], "canonical_name": "initiation of acetate catabolic process by acetate", "definition": "The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. [PMID:11741859]"}
{"concept_id": "C1154664", "aliases": ["regulation of initiation of acetate breakdown by acetate", "regulation of initiation of acetate degradation by acetate"], "types": ["T043"], "canonical_name": "regulation of initiation of acetate catabolic process by acetate", "definition": "Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. [GOC:go_curators]"}
{"concept_id": "C1154665", "aliases": ["downregulation of initiation of acetate catabolic process by acetate", "down regulation of initiation of acetate catabolic process by acetate", "negative regulation of initiation of acetate degradation by acetate", "down-regulation of initiation of acetate catabolic process by acetate", "negative regulation of initiation of acetate breakdown by acetate"], "types": ["T043"], "canonical_name": "negative regulation of initiation of acetate catabolic process by acetate", "definition": "Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. [GOC:go_curators]"}
{"concept_id": "C1154666", "aliases": ["positive regulation of initiation of acetate degradation by acetate", "up-regulation of initiation of acetate catabolic process by acetate", "positive regulation of initiation of acetate breakdown by acetate", "upregulation of initiation of acetate catabolic process by acetate", "up regulation of initiation of acetate catabolic process by acetate"], "types": ["T043"], "canonical_name": "positive regulation of initiation of acetate catabolic process by acetate", "definition": "Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. [GOC:go_curators]"}
{"concept_id": "C1154667", "aliases": ["antibiotic metabolism"], "types": ["T044"], "canonical_name": "antibiotic metabolic process", "definition": "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. [GOC:cab2]"}
{"concept_id": "C1154668", "aliases": ["aminoglycoside antibiotic metabolism"], "types": ["T044"], "canonical_name": "aminoglycoside antibiotic metabolic process", "definition": "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1154669", "aliases": ["aminoglycoside antibiotic synthesis", "aminoglycoside antibiotic formation", "aminoglycoside antibiotic biosynthesis", "aminoglycoside antibiotic anabolism"], "types": ["T044"], "canonical_name": "aminoglycoside antibiotic biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1154670", "aliases": ["streptomycin biosynthesis", "streptomycin anabolism", "streptomycin formation", "streptomycin synthesis"], "types": ["T044"], "canonical_name": "streptomycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. [GOC:curators]"}
{"concept_id": "C1154671", "aliases": ["aminoglycoside antibiotic breakdown", "aminoglycoside antibiotic catabolism", "aminoglycoside antibiotic degradation"], "types": ["T044"], "canonical_name": "aminoglycoside antibiotic catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1154672", "aliases": ["streptomycin metabolism"], "types": ["T044"], "canonical_name": "streptomycin metabolic process", "definition": "The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. [PMID:2111804]"}
{"concept_id": "C1154673", "aliases": ["antibiotic anabolism", "antibiotic formation", "antibiotic synthesis", "antibiotic biosynthesis"], "types": ["T044"], "canonical_name": "antibiotic biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. [GOC:go_curators]"}
{"concept_id": "C1154674", "aliases": ["bacteriocin biosynthesis", "bacteriocin synthesis", "bacteriocin anabolism", "bacteriocin formation"], "types": ["T044"], "canonical_name": "bacteriocin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1154675", "aliases": ["beta-lactam antibiotic anabolism", "beta-lactam antibiotic synthesis", "beta-lactam antibiotic formation", "beta-lactam antibiotic biosynthesis"], "types": ["T044"], "canonical_name": "beta-lactam antibiotic biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1154676", "aliases": ["penicillin anabolism", "penicillin synthesis", "penicillin formation", "penicillin biosynthesis"], "types": ["T044"], "canonical_name": "penicillin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154677", "aliases": ["enniatin anabolism", "enniatin biosynthesis", "enniatin synthesis", "enniatin formation"], "types": ["T044"], "canonical_name": "enniatin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores. [ISBN:0198506732]"}
{"concept_id": "C1154678", "aliases": ["peptide antibiotic formation", "peptide antibiotic anabolism", "peptide antibiotic biosynthesis", "peptide antibiotic synthesis"], "types": ["T044"], "canonical_name": "peptide antibiotic biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity. [GOC:mah]"}
{"concept_id": "C1154679", "aliases": ["antibiotic catabolism", "antibiotic degradation", "antibiotic breakdown"], "types": ["T044"], "canonical_name": "antibiotic catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. [GOC:go_curators]"}
{"concept_id": "C1154680", "aliases": ["bacteriocin breakdown", "bacteriocin degradation", "bacteriocin catabolism"], "types": ["T044"], "canonical_name": "bacteriocin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. [GOC:ai]"}
{"concept_id": "C1154681", "aliases": ["beta-lactam antibiotic catabolism", "beta-lactam antibiotic degradation", "beta-lactam antibiotic breakdown"], "types": ["T044"], "canonical_name": "beta-lactam antibiotic catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1154682", "aliases": ["penicillin breakdown", "penicillin catabolism", "penicillin degradation"], "types": ["T044"], "canonical_name": "penicillin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154683", "aliases": ["peptide antibiotic catabolism", "peptide antibiotic degradation", "peptide antibiotic breakdown"], "types": ["T044"], "canonical_name": "peptide antibiotic catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity. [GOC:mah]"}
{"concept_id": "C1154684", "aliases": ["bacteriocin metabolism"], "types": ["T044"], "canonical_name": "bacteriocin metabolic process", "definition": "The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. [GOC:ai]"}
{"concept_id": "C1154685", "aliases": ["beta-lactam antibiotic metabolism"], "types": ["T044"], "canonical_name": "beta-lactam antibiotic metabolic process", "definition": "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1154686", "aliases": ["penicillin metabolism"], "types": ["T044"], "canonical_name": "penicillin metabolic process", "definition": "The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1154687", "aliases": ["enniatin metabolism"], "types": ["T044"], "canonical_name": "enniatin metabolic process", "definition": "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores. [ISBN:0198506732]"}
{"concept_id": "C1154688", "aliases": ["peptide antibiotic metabolism"], "types": ["T044"], "canonical_name": "peptide antibiotic metabolic process", "definition": "The chemical reactions and pathways involving peptides with antibiotic activity. [GOC:mah]"}
{"concept_id": "C1154689", "aliases": [], "types": ["T043"], "definition": "Any subcellular or molecular event, process, or condition involved in translocation of a drug from one site or compartment to another. (NCI)", "canonical_name": "drug transport"}
{"concept_id": "C1154690", "aliases": ["acriflavin transport"], "types": ["T043"], "canonical_name": "acriflavine transport", "definition": "The directed movement of acriflavine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. [GOC:curators, PubChem_Compound:6842]"}
{"concept_id": "C1154691", "aliases": [], "types": ["T043"], "canonical_name": "alkane transport", "definition": "The directed movement of alkanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds. [GOC:ai]"}
{"concept_id": "C1154692", "aliases": [], "types": ["T043"], "canonical_name": "amiloride transport", "definition": "The directed movement amiloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic. [GOC:ai]"}
{"concept_id": "C1154693", "aliases": [], "types": ["T043"], "canonical_name": "azole transport"}
{"concept_id": "C1154694", "aliases": [], "types": ["T043"], "canonical_name": "aminotriazole transport", "definition": "The directed movement of aminotriazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminotriazole is an effective weed killer that also possesses some antithyroid activity. [GOC:curators]"}
{"concept_id": "C1154695", "aliases": [], "types": ["T043"], "canonical_name": "fluconazole transport", "definition": "The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections. [GOC:curators]"}
{"concept_id": "C1154696", "aliases": ["sulphathiazole transport"], "types": ["T043"], "canonical_name": "sulfathiazole transport"}
{"concept_id": "C1154697", "aliases": [], "types": ["T043"], "canonical_name": "benomyl transport", "definition": "The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit. [GOC:curators]"}
{"concept_id": "C1154698", "aliases": [], "types": ["T043"], "canonical_name": "bicyclomycin transport"}
{"concept_id": "C1154699", "aliases": ["CCCP transport"], "types": ["T043"], "canonical_name": "carbonyl cyanide m-chlorophenylhydrazone transport", "definition": "The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. [GOC:curators]"}
{"concept_id": "C1154700", "aliases": [], "types": ["T043"], "canonical_name": "cycloheximide transport", "definition": "The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes. [ISBN:0198506732]"}
{"concept_id": "C1154701", "aliases": [], "types": ["T043"], "canonical_name": "drug export"}
{"concept_id": "C1154702", "aliases": [], "types": ["T043"], "canonical_name": "multidrug transport"}
{"concept_id": "C1154703", "aliases": [], "types": ["T043"], "canonical_name": "nalidixic acid transport", "definition": "The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication. [GOC:curators, PMID:12702699, PubChem_Compound:4221]"}
{"concept_id": "C1154704", "aliases": [], "types": ["T043"], "canonical_name": "organomercurial transport", "definition": "The process in which an organomercurial compound is transported across a membrane. Organomercurial substances are any organic compound containing a mercury atom. [GOC:ai, PMID:18793329]"}
{"concept_id": "C1154705", "aliases": ["tetracyclin transport"], "types": ["T043"], "canonical_name": "tetracycline transport"}
{"concept_id": "C1154706", "aliases": [], "types": ["T043"], "canonical_name": "response to antibiotic", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. [GOC:ai, GOC:ef]"}
{"concept_id": "C1154707", "aliases": [], "types": ["T043"], "canonical_name": "response to bacteriocin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation. [ISBN:0721662544]"}
{"concept_id": "C1154708", "aliases": [], "types": ["T043"], "canonical_name": "response to streptomycin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. [GOC:curators]"}
{"concept_id": "C1154709", "aliases": [], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:ef, GOC:jl]", "canonical_name": "response to cocaine"}
{"concept_id": "C1154710", "aliases": [], "types": ["T043"], "canonical_name": "response to ethanol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators]"}
{"concept_id": "C1154711", "aliases": [], "types": ["T043"], "canonical_name": "response to ether", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. [GOC:go_curators]"}
{"concept_id": "C1154713", "aliases": [], "types": ["T040"], "canonical_name": "response to heavy metal", "definition": "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. [GOC:ai]"}
{"concept_id": "C1154714", "aliases": ["metal chelating activity"], "types": ["T044"], "definition": "The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring. [ISBN:0198506732, ISBN:0716731363]", "canonical_name": "metal chelation"}
{"concept_id": "C1154716", "aliases": ["response to cadmium"], "types": ["T040"], "canonical_name": "response to cadmium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. [GOC:ai]"}
{"concept_id": "C1154717", "aliases": [], "types": ["T043"], "canonical_name": "response to chromate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus. [ISBN:0721662544]"}
{"concept_id": "C1154718", "aliases": ["response to copper"], "types": ["T040"], "canonical_name": "response to copper ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. [GOC:ai]"}
{"concept_id": "C1154719", "aliases": ["response to mercury", "response to mercuric ion"], "types": ["T040"], "canonical_name": "response to mercury ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. [GOC:ai]"}
{"concept_id": "C1154720", "aliases": ["response to tellurium"], "types": ["T040"], "canonical_name": "response to tellurium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus. [GOC:ai]"}
{"concept_id": "C1154721", "aliases": [], "types": ["T040"], "canonical_name": "response to herbicide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants. [GOC:curators]"}
{"concept_id": "C1154722", "aliases": [], "types": ["T040"], "canonical_name": "response to insecticide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. [GOC:curators]"}
{"concept_id": "C1154723", "aliases": ["insecticide metabolism"], "types": ["T044"], "canonical_name": "insecticide metabolic process", "definition": "The chemical reactions and pathways involving insecticides, chemicals used to kill insects. [GOC:ai]"}
{"concept_id": "C1154724", "aliases": ["1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism", "DDT metabolism", "DDT metabolic process"], "types": ["T044"], "canonical_name": "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process", "definition": "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide. [GOC:jl]"}
{"concept_id": "C1154725", "aliases": ["1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown", "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism", "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation", "DDT catabolism", "DDT catabolic process"], "types": ["T044"], "canonical_name": "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide. [GOC:jl]"}
{"concept_id": "C1154726", "aliases": ["anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism", "anaerobic DDT metabolic process", "anaerobic DDT metabolism"], "types": ["T044"], "canonical_name": "anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process", "definition": "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen. [GOC:jl]"}
{"concept_id": "C1154727", "aliases": ["insecticide catabolism", "insecticide breakdown", "insecticide degradation"], "types": ["T044"], "canonical_name": "insecticide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects. [GOC:ai]"}
{"concept_id": "C1154728", "aliases": [], "types": ["T043"], "canonical_name": "response to carbamate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase. [ISBN:0721662544]"}
{"concept_id": "C1154729", "aliases": [], "types": ["T043"], "canonical_name": "response to cyclodiene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring. [ISBN:0877797099]"}
{"concept_id": "C1154730", "aliases": [], "types": ["T043"], "canonical_name": "response to DDT", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals. [ISBN:0721662544]"}
{"concept_id": "C1154731", "aliases": [], "types": ["T040"], "canonical_name": "response to organophosphorus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. [ISBN:0721662544]"}
{"concept_id": "C1154732", "aliases": [], "types": ["T043"], "canonical_name": "response to pyrethroid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage. [ISBN:0721662544]"}
{"concept_id": "C1154733", "aliases": ["aflatoxin metabolism"], "types": ["T044"], "canonical_name": "aflatoxin metabolic process", "definition": "The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. [GOC:ai]"}
{"concept_id": "C1154734", "aliases": ["aflatoxin synthesis", "aflatoxin anabolism", "aflatoxin formation", "aflatoxin biosynthesis"], "types": ["T044"], "canonical_name": "aflatoxin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. [ISBN:0716731363, ISBN:0815316194, PMID:15006741]"}
{"concept_id": "C1154735", "aliases": ["aflatoxin breakdown", "aflatoxin catabolism", "aflatoxin degradation"], "types": ["T044"], "canonical_name": "aflatoxin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. [GOC:ai]"}
{"concept_id": "C1154736", "aliases": ["sterigmatocystin metabolism"], "types": ["T043"], "canonical_name": "sterigmatocystin metabolic process", "definition": "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. [PMID:10618248]"}
{"concept_id": "C1154737", "aliases": ["sterigmatocystin biosynthesis", "sterigmatocystin anabolism", "sterigmatocystin synthesis", "sterigmatocystin formation"], "types": ["T044"], "canonical_name": "sterigmatocystin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. [PMID:10618248]"}
{"concept_id": "C1154738", "aliases": ["sterigmatocystin degradation", "sterigmatocystin catabolism", "sterigmatocystin breakdown"], "types": ["T044"], "canonical_name": "sterigmatocystin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. [GOC:go_curators]"}
{"concept_id": "C1154739", "aliases": ["toxin biosynthesis", "toxin formation", "toxin anabolism", "toxin synthesis"], "types": ["T044"], "canonical_name": "toxin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. [GOC:go_curators]"}
{"concept_id": "C1154740", "aliases": ["toxin degradation", "toxin breakdown", "toxin catabolism"], "types": ["T044"], "canonical_name": "toxin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. [GOC:go_curators]"}
{"concept_id": "C1154741", "aliases": [], "types": ["T043"], "canonical_name": "toxin resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1154742", "aliases": [], "types": ["T040"], "canonical_name": "bacteriocin immunity", "definition": "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1154743", "aliases": [], "types": ["T040"], "canonical_name": "response to xenobiotic stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]"}
{"concept_id": "C1154744", "aliases": ["xenobiotic metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]", "canonical_name": "xenobiotic metabolic process"}
{"concept_id": "C1154745", "aliases": ["2-nitropropane metabolism"], "types": ["T044"], "canonical_name": "2-nitropropane metabolic process", "definition": "The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol. [UM-BBD_pathwayID:npp]"}
{"concept_id": "C1154746", "aliases": ["2-nitropropane breakdown", "2-nitropropane catabolism", "2-nitropropane degradation"], "types": ["T044"], "canonical_name": "2-nitropropane catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. [GOC:ai]"}
{"concept_id": "C1154747", "aliases": ["ethyne metabolic process", "ethyne metabolism", "acetylene metabolism"], "types": ["T044"], "canonical_name": "acetylene metabolic process", "definition": "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes. [ISBN:0721662544]"}
{"concept_id": "C1154748", "aliases": ["anaerobic acetylene degradation", "anaerobic acetylene breakdown", "anaerobic ethyne catabolism", "anaerobic ethyne catabolic process", "anaerobic acetylene catabolism"], "types": ["T044"], "canonical_name": "anaerobic acetylene catabolic process", "definition": "The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen. [ISBN:0721662544]"}
{"concept_id": "C1154749", "aliases": ["acrylonitrile metabolism"], "types": ["T044"], "canonical_name": "acrylonitrile metabolic process", "definition": "The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers. [http://www.iversonsoftware.com/reference/chemistry/a/acrylonitrile.htm]"}
{"concept_id": "C1154750", "aliases": ["acrylonitrile degradation", "acrylonitrile breakdown", "acrylonitrile catabolism"], "types": ["T044"], "canonical_name": "acrylonitrile catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers. [GOC:ai]"}
{"concept_id": "C1154751", "aliases": ["adamantanone metabolism"], "types": ["T044"], "canonical_name": "adamantanone metabolic process", "definition": "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists. [GOC:ai]"}
{"concept_id": "C1154752", "aliases": ["adamantanone degradation", "adamantanone breakdown", "adamantanone catabolism"], "types": ["T044"], "canonical_name": "adamantanone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists. [GOC:ai]"}
{"concept_id": "C1154753", "aliases": ["arsonoacetate metabolism"], "types": ["T044"], "canonical_name": "arsonoacetate metabolic process", "definition": "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides. [UM-BBD_pathwayID:ara]"}
{"concept_id": "C1154754", "aliases": ["arsonoacetate degradation", "arsonoacetate breakdown", "arsonoacetate catabolism"], "types": ["T044"], "canonical_name": "arsonoacetate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom. [GOC:jl]"}
{"concept_id": "C1154755", "aliases": ["benzene and derivative metabolic process", "benzene-containing compound metabolism", "benzene and derivative metabolism"], "types": ["T044"], "canonical_name": "benzene-containing compound metabolic process", "definition": "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. [GOC:jl]"}
{"concept_id": "C1154756", "aliases": ["1,2,4-trichlorobenzene metabolism"], "types": ["T044"], "canonical_name": "1,2,4-trichlorobenzene metabolic process", "definition": "The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides. [http://www.speclab.com/compound/c120821.htm]"}
{"concept_id": "C1154757", "aliases": ["1,4-dichlorobenzene metabolism"], "types": ["T044"], "canonical_name": "1,4-dichlorobenzene metabolic process", "definition": "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs. [http://www.speclab.com/compound/c106467.htm]"}
{"concept_id": "C1154758", "aliases": ["1,4-dichlorobenzene catabolism", "1,4-dichlorobenzene breakdown", "1,4-dichlorobenzene degradation"], "types": ["T044"], "canonical_name": "1,4-dichlorobenzene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. [GOC:ai]"}
{"concept_id": "C1154759", "aliases": ["2,4,5-T metabolic process", "2,4,5-trichlorophenoxyacetic acid metabolism", "2,4,5-T metabolism"], "types": ["T044"], "canonical_name": "2,4,5-trichlorophenoxyacetic acid metabolic process", "definition": "The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns. [UM-BBD_pathwayID:2,4,5-t]"}
{"concept_id": "C1154760", "aliases": ["2,4,5-trichlorophenoxyacetic acid catabolism", "2,4,5-trichlorophenoxyacetic acid degradation", "2,4,5-trichlorophenoxyacetic acid breakdown"], "types": ["T044"], "canonical_name": "2,4,5-trichlorophenoxyacetic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide. [GOC:ai]"}
{"concept_id": "C1154761", "aliases": ["2,4-dichlorophenoxyacetic acid metabolism", "2,4-D metabolism", "2,4-D metabolic process"], "types": ["T044"], "canonical_name": "2,4-dichlorophenoxyacetic acid metabolic process", "definition": "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds. [UM-BBD_pathwayID:2,4d]"}
{"concept_id": "C1154762", "aliases": ["2,4-dichlorophenoxyacetic acid degradation", "2,4-dichlorophenoxyacetic acid breakdown", "2,4-dichlorophenoxyacetic acid catabolism"], "types": ["T044"], "canonical_name": "2,4-dichlorophenoxyacetic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds. [GOC:ai]"}
{"concept_id": "C1154763", "aliases": ["2-aminobenzenesulphonate metabolic process", "2-aminobenzenesulfonate metabolism", "2-aminobenzenesulphonate metabolism"], "types": ["T044"], "canonical_name": "2-aminobenzenesulfonate metabolic process", "definition": "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. [UM-BBD_pathwayID:abs]"}
{"concept_id": "C1154764", "aliases": ["2-aminobenzenesulfonate catabolism", "2-aminobenzenesulfonate degradation", "2-aminobenzenesulphonate catabolic process", "2-aminobenzenesulphonate catabolism", "2-aminobenzenesulfonate breakdown"], "types": ["T044"], "canonical_name": "2-aminobenzenesulfonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. [GOC:ai]"}
{"concept_id": "C1154765", "aliases": ["2-aminobenzenesulphonate desulphonation"], "types": ["T044"], "canonical_name": "2-aminobenzenesulfonate desulfonation", "definition": "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. [UM-BBD_pathwayID:abs]"}
{"concept_id": "C1154766", "aliases": ["propachlor metabolism", "2-chloro-N-isopropylacetanilide metabolism", "propachlor metabolic process"], "types": ["T044"], "canonical_name": "2-chloro-N-isopropylacetanilide metabolic process", "definition": "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants. [UM-BBD_pathwayID:ppc]"}
{"concept_id": "C1154767", "aliases": ["2-chloro-N-isopropylacetanilide breakdown", "2-chloro-N-isopropylacetanilide catabolism", "2-chloro-N-isopropylacetanilide degradation"], "types": ["T044"], "canonical_name": "2-chloro-N-isopropylacetanilide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants. [GOC:ai]"}
{"concept_id": "C1154768", "aliases": ["3-hydroxyphenylacetate metabolism", "3HPA metabolic process", "3HPA metabolism"], "types": ["T044"], "canonical_name": "3-hydroxyphenylacetate metabolic process", "definition": "The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate. [http://chemfinder.cambridgesoft.com/]"}
{"concept_id": "C1154769", "aliases": ["3-hydroxyphenylacetate breakdown", "3-hydroxyphenylacetate degradation", "3-hydroxyphenylacetate catabolism"], "types": ["T044"], "canonical_name": "3-hydroxyphenylacetate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate. [http://chemfinder.cambridgesoft.com/]"}
{"concept_id": "C1154770", "aliases": ["3-methylquinoline metabolism"], "types": ["T044"], "canonical_name": "3-methylquinoline metabolic process", "definition": "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring. [GOC:ai]"}
{"concept_id": "C1154771", "aliases": ["3-methylquinoline degradation", "3-methylquinoline catabolism", "3-methylquinoline breakdown"], "types": ["T044"], "canonical_name": "3-methylquinoline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring. [GOC:ai]"}
{"concept_id": "C1154772", "aliases": ["hydrocinnamic acid metabolic process", "phenylpropanoate metabolism", "hydrocinnamic acid metabolism", "phenylpropanoate metabolic process", "3-phenylpropionate metabolism"], "types": ["T044"], "canonical_name": "3-phenylpropionate metabolic process", "definition": "The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins. [GOC:ai, UM-BBD_pathwayID:ppa]"}
{"concept_id": "C1154773", "aliases": ["3-(3-hydroxy)phenylpropionate metabolism"], "types": ["T044"], "canonical_name": "3-(3-hydroxy)phenylpropionate metabolic process", "definition": "The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. [GOC:ai]"}
{"concept_id": "C1154774", "aliases": ["3-(3-hydroxy)phenylpropionate breakdown", "3-(3-hydroxy)phenylpropionate degradation", "3-(3-hydroxy)phenylpropionate catabolism"], "types": ["T044"], "canonical_name": "3-(3-hydroxy)phenylpropionate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. [GOC:ai]"}
{"concept_id": "C1154775", "aliases": ["3-phenylpropionate catabolism", "3-phenylpropionate breakdown", "3-phenylpropionate degradation"], "types": ["T044"], "canonical_name": "3-phenylpropionate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid. [GOC:ai]"}
{"concept_id": "C1154776", "aliases": ["4-carboxy-4'-sulphoazobenzene metabolism", "4-carboxy-4'-sulfoazobenzene metabolism", "4-carboxy-4'-sulphoazobenzene metabolic process"], "types": ["T044"], "canonical_name": "4-carboxy-4'-sulfoazobenzene metabolic process", "definition": "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid. [PMID:9603860]"}
{"concept_id": "C1154777", "aliases": ["p-nitrophenol metabolism", "p-nitrophenol metabolic process", "4-nitrophenol metabolism"], "types": ["T044"], "canonical_name": "4-nitrophenol metabolic process", "definition": "The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion. [GOC:jl]"}
{"concept_id": "C1154778", "aliases": ["4-nitrophenol degradation", "4-nitrophenol catabolism", "4-nitrophenol breakdown"], "types": ["T044"], "canonical_name": "4-nitrophenol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion. [GOC:ai]"}
{"concept_id": "C1154779", "aliases": ["benzene metabolism"], "types": ["T044"], "canonical_name": "benzene metabolic process", "definition": "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation. [GOC:ai]"}
{"concept_id": "C1154780", "aliases": ["benzoate metabolism"], "types": ["T044"], "canonical_name": "benzoate metabolic process", "definition": "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. [ISBN:0721662544]"}
{"concept_id": "C1154781", "aliases": ["(R)-mandelate degradation to benzoate", "(R)-mandelate breakdown to benzoate"], "types": ["T044"], "canonical_name": "(R)-mandelate catabolic process to benzoate", "definition": "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate. [GOC:go_curators]"}
{"concept_id": "C1154782", "aliases": ["2,4-dichlorobenzoate metabolism"], "types": ["T044"], "canonical_name": "2,4-dichlorobenzoate metabolic process", "definition": "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs). [GOC:jl, UM-BBD_pathwayID:dcb]"}
{"concept_id": "C1154783", "aliases": ["2,4-dichlorobenzoate breakdown", "2,4-dichlorobenzoate catabolism", "2,4-dichlorobenzoate degradation"], "types": ["T044"], "canonical_name": "2,4-dichlorobenzoate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs). [GOC:ai]"}
{"concept_id": "C1154786", "aliases": ["anaerobic 2-aminobenzoate metabolism"], "types": ["T044"], "canonical_name": "anaerobic 2-aminobenzoate metabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1154787", "aliases": ["aerobic benzoate metabolism"], "types": ["T044"], "canonical_name": "aerobic benzoate metabolic process", "definition": "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen. [GOC:ai]"}
{"concept_id": "C1154788", "aliases": ["anaerobic benzoate metabolism"], "types": ["T044"], "canonical_name": "anaerobic benzoate metabolic process", "definition": "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1154789", "aliases": ["benzonitrile metabolism"], "types": ["T044"], "canonical_name": "benzonitrile metabolic process", "definition": "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin. [UM-BBD_pathwayID:bzn]"}
{"concept_id": "C1154790", "aliases": ["xenene metabolism", "biphenyl metabolism", "xenene metabolic process"], "types": ["T044"], "canonical_name": "biphenyl metabolic process", "definition": "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs). [GOC:jl]"}
{"concept_id": "C1154791", "aliases": ["4-chlorobiphenyl metabolism"], "types": ["T044"], "canonical_name": "4-chlorobiphenyl metabolic process", "definition": "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation. [GOC:jl]"}
{"concept_id": "C1154792", "aliases": ["bromoxynil metabolism"], "types": ["T044"], "canonical_name": "bromoxynil metabolic process", "definition": "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants. [GOC:ai]"}
{"concept_id": "C1154793", "aliases": ["CAR metabolic process", "CAR metabolism", "carbazole metabolism"], "types": ["T044"], "canonical_name": "carbazole metabolic process", "definition": "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen. [GOC:jl]"}
{"concept_id": "C1154794", "aliases": ["carbazole catabolism", "carbazole breakdown", "carbazole degradation"], "types": ["T044"], "canonical_name": "carbazole catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen. [GOC:ai]"}
{"concept_id": "C1154795", "aliases": ["chlorobenzene metabolism"], "types": ["T044"], "canonical_name": "chlorobenzene metabolic process", "definition": "The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone. [http://www.shsu.edu/]"}
{"concept_id": "C1154796", "aliases": ["oxanthrene metabolism", "dibenzo-p-dioxin metabolism", "oxanthrene metabolic process", "phenodioxin metabolic process", "phenodioxin metabolism"], "types": ["T044"], "canonical_name": "dibenzo-p-dioxin metabolic process", "definition": "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern. [UM-BBD_pathwayID:dpd]"}
{"concept_id": "C1154797", "aliases": ["dibenzo-p-dioxin degradation", "dibenzo-p-dioxin breakdown", "dibenzo-p-dioxin catabolism"], "types": ["T044"], "canonical_name": "dibenzo-p-dioxin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. [GOC:ai]"}
{"concept_id": "C1154798", "aliases": ["dibenzofuran metabolism"], "types": ["T044"], "canonical_name": "dibenzofuran metabolic process", "definition": "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals. [GOC:ai, UM-BBD_pathwayID:dbf]"}
{"concept_id": "C1154799", "aliases": ["dibenzofuran degradation", "dibenzofuran breakdown", "dibenzofuran catabolism"], "types": ["T044"], "canonical_name": "dibenzofuran catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. [GOC:ai]"}
{"concept_id": "C1154800", "aliases": ["diphenylene sulfide metabolism", "diphenylene sulfide metabolic process", "dibenzothiophene metabolism"], "types": ["T044"], "canonical_name": "dibenzothiophene metabolic process", "definition": "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion. [PMID:12147483]"}
{"concept_id": "C1154801", "aliases": ["dibenzothiophene catabolism", "dibenzothiophene degradation", "dibenzothiophene breakdown"], "types": ["T044"], "canonical_name": "dibenzothiophene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. [GOC:ai]"}
{"concept_id": "C1154802", "aliases": ["dibenzothiophene desulphurization"], "types": ["T044"], "canonical_name": "dibenzothiophene desulfurization", "definition": "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. [GOC:ai]"}
{"concept_id": "C1154803", "aliases": ["ethylbenzene metabolism"], "types": ["T044"], "canonical_name": "ethylbenzene metabolic process", "definition": "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels. [http://www.speclab.com/compound/c100414.htm]"}
{"concept_id": "C1154804", "aliases": ["anaerobic ethylbenzene metabolism"], "types": ["T044"], "canonical_name": "anaerobic ethylbenzene metabolic process", "definition": "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1154806", "aliases": ["fluorene metabolism", "fluorene catabolism", "fluorene breakdown", "fluorene degradation"], "types": ["T044"], "canonical_name": "fluorene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents. [PMID:15317800]"}
{"concept_id": "C1154807", "aliases": ["iprodione metabolism"], "types": ["T044"], "canonical_name": "iprodione metabolic process", "definition": "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium). [UM-BBD_pathwayID:ipd]"}
{"concept_id": "C1154809", "aliases": ["naphthalenesulfonate metabolism", "naphthalenesulphonate metabolic process", "naphthalenesulphonate metabolism"], "types": ["T044"], "canonical_name": "naphthalenesulfonate metabolic process", "definition": "The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene. [GOC:ai]"}
{"concept_id": "C1154810", "aliases": ["nitrobenzene metabolism"], "types": ["T044"], "canonical_name": "nitrobenzene metabolic process", "definition": "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline. [GOC:curators]"}
{"concept_id": "C1154811", "aliases": ["parathion metabolism"], "types": ["T044"], "canonical_name": "parathion metabolic process", "definition": "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition. [UM-BBD_pathwayID:pthn]"}
{"concept_id": "C1154812", "aliases": ["parathion degradation", "parathion catabolism", "parathion breakdown"], "types": ["T044"], "canonical_name": "parathion catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition. [UM-BBD_pathwayID:pthn]"}
{"concept_id": "C1154813", "aliases": ["phenanthrene metabolism"], "types": ["T044"], "canonical_name": "phenanthrene metabolic process", "definition": "The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish. [GOC:jl, UM-BBD_pathwayID:pha]"}
{"concept_id": "C1154814", "aliases": ["phenanthrene degradation", "phenanthrene catabolism", "phenanthrene breakdown"], "types": ["T044"], "canonical_name": "phenanthrene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon. [GOC:jl]"}
{"concept_id": "C1154815", "aliases": ["phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene", "phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene"], "types": ["T044"], "canonical_name": "phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene", "definition": "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite. [UM-BBD_pathwayID:pha3]"}
{"concept_id": "C1154816", "aliases": ["phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene", "phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene"], "types": ["T044"], "canonical_name": "phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene", "definition": "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite. [UM-BBD_pathwayID:pha2]"}
{"concept_id": "C1154817", "aliases": ["phenylmercury acetate metabolism"], "types": ["T044"], "canonical_name": "phenylmercury acetate metabolic process", "definition": "The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group. [GOC:ai]"}
{"concept_id": "C1154818", "aliases": ["phenylmercury acetate catabolism", "phenylmercury acetate degradation", "phenylmercury acetate breakdown"], "types": ["T044"], "canonical_name": "phenylmercury acetate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group. [GOC:ai]"}
{"concept_id": "C1154819", "aliases": ["phthalic acid metabolic process", "phthalate metabolism", "phthalic acid metabolism"], "types": ["T044"], "canonical_name": "phthalate metabolic process", "definition": "The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses. [UM-BBD_pathwayID:pth]"}
{"concept_id": "C1154820", "aliases": ["phthalate breakdown", "phthalate catabolism", "phthalate degradation"], "types": ["T044"], "canonical_name": "phthalate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid. [GOC:ai]"}
{"concept_id": "C1154821", "aliases": ["1,3-benzenediol metabolic process", "1,3-dihydroxybenzene metabolic process", "1,3-benzenediol metabolism", "1,3-dihydroxybenzene metabolism", "resorcinol metabolism"], "types": ["T044"], "canonical_name": "resorcinol metabolic process", "definition": "The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic. [GOC:jl, http://www.speclab.com/compound/c108463.htm]"}
{"concept_id": "C1154822", "aliases": ["styrene metabolism"], "types": ["T044"], "canonical_name": "styrene metabolic process", "definition": "The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen. [GOC:jl, UM-BBD_pathwayID:sty]"}
{"concept_id": "C1154823", "aliases": ["styrene breakdown", "styrene catabolism", "styrene degradation"], "types": ["T044"], "canonical_name": "styrene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene. [GOC:jl]"}
{"concept_id": "C1154824", "aliases": ["toluene metabolism", "methylbenzene metabolic process", "methylbenzene metabolism"], "types": ["T044"], "canonical_name": "toluene metabolic process", "definition": "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications. [UM-BBD_pathwayID:tol]"}
{"concept_id": "C1154825", "aliases": ["4-toluenecarboxylate metabolism", "p-toluate metabolism", "p-toluate metabolic process"], "types": ["T044"], "canonical_name": "4-toluenecarboxylate metabolic process", "definition": "The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule. [GOC:ai]"}
{"concept_id": "C1154826", "aliases": ["4-toluenecarboxylate catabolism", "p-toluate catabolism", "4-toluenecarboxylate degradation", "p-toluate catabolic process", "4-toluenecarboxylate breakdown"], "types": ["T044"], "canonical_name": "4-toluenecarboxylate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule. [GOC:ai]"}
{"concept_id": "C1154827", "aliases": ["anaerobic toluene metabolism"], "types": ["T044"], "canonical_name": "anaerobic toluene metabolic process", "definition": "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1154828", "aliases": ["anaerobic 2,4,6-trinitrotoluene metabolism"], "types": ["T044"], "canonical_name": "anaerobic 2,4,6-trinitrotoluene metabolic process", "definition": "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1154829", "aliases": ["anaerobic 2,4,6-trinitrotoluene degradation", "anaerobic 2,4,6-trinitrotoluene breakdown", "anaerobic 2,4,6-trinitrotoluene catabolism"], "types": ["T044"], "canonical_name": "anaerobic 2,4,6-trinitrotoluene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1154830", "aliases": ["anaerobic toluene breakdown", "anaerobic toluene degradation", "anaerobic toluene catabolism"], "types": ["T044"], "canonical_name": "anaerobic toluene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1154831", "aliases": ["hydroxytoluene metabolic process", "cresol metabolism", "hydroxytoluene metabolism"], "types": ["T044"], "canonical_name": "cresol metabolic process", "definition": "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote. [UM-BBD_pathwayID:mcr]"}
{"concept_id": "C1154832", "aliases": ["cresol catabolism", "cresol breakdown", "cresol degradation"], "types": ["T044"], "canonical_name": "cresol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote. [GOC:ai]"}
{"concept_id": "C1154833", "aliases": ["3-hydroxytoluene catabolism", "m-cresol degradation", "meta-cresol catabolism", "3-hydroxytoluene catabolic process", "m-cresol breakdown", "meta-cresol catabolic process", "m-cresol catabolism"], "types": ["T044"], "canonical_name": "m-cresol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol. [GOC:jl]"}
{"concept_id": "C1154834", "aliases": ["meta-cresol metabolic process", "meta-cresol metabolism", "3-hydroxytoluene metabolic process", "3-hydroxytoluene metabolism", "m-cresol metabolism"], "types": ["T044"], "canonical_name": "m-cresol metabolic process", "definition": "The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes. [GOC:jl]"}
{"concept_id": "C1154835", "aliases": ["nitrotoluene metabolism"], "types": ["T044"], "canonical_name": "nitrotoluene metabolic process", "definition": "The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached. [GOC:ai]"}
{"concept_id": "C1154836", "aliases": ["4NT metabolic process", "4-nitrotoluene metabolism", "4NT metabolism"], "types": ["T044"], "canonical_name": "4-nitrotoluene metabolic process", "definition": "The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor. [GOC:ai]"}
{"concept_id": "C1154837", "aliases": ["4NT catabolic process", "4-nitrotoluene breakdown", "4-nitrotoluene catabolism", "4-nitrotoluene degradation", "4NT catabolism"], "types": ["T044"], "canonical_name": "4-nitrotoluene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene. [GOC:ai]"}
{"concept_id": "C1154838", "aliases": ["nitrotoluene catabolism", "nitrotoluene breakdown", "nitrotoluene degradation"], "types": ["T044"], "canonical_name": "nitrotoluene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached. [GOC:ai]"}
{"concept_id": "C1154839", "aliases": ["trinitrotoluene breakdown", "trinitrotoluene degradation", "trinitrotoluene catabolism"], "types": ["T044"], "canonical_name": "trinitrotoluene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene. [GOC:ai]"}
{"concept_id": "C1154840", "aliases": ["2,4,6-trinitrotoluene degradation", "2,4,6-trinitrotoluene breakdown", "2,4,6-trinitrotoluene catabolism"], "types": ["T044"], "canonical_name": "2,4,6-trinitrotoluene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. [GOC:ai]"}
{"concept_id": "C1154841", "aliases": ["trinitrotoluene metabolism"], "types": ["T044"], "canonical_name": "trinitrotoluene metabolic process", "definition": "The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene. [GOC:ai]"}
{"concept_id": "C1154842", "aliases": ["2,4,6-trinitrotoluene metabolism", "TNT metabolism", "TNT metabolic process"], "types": ["T044"], "canonical_name": "2,4,6-trinitrotoluene metabolic process", "definition": "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives. [ISBN:0333781767]"}
{"concept_id": "C1154843", "aliases": ["orcin metabolic process", "orcinol metabolism", "orcin metabolism"], "types": ["T044"], "canonical_name": "orcinol metabolic process", "definition": "The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants. [GOC:jl]"}
{"concept_id": "C1154844", "aliases": ["orcinol formation", "orcinol biosynthesis", "orcinol anabolism", "orcinol synthesis"], "types": ["T044"], "canonical_name": "orcinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants. [GOC:ai]"}
{"concept_id": "C1154845", "aliases": ["orcinol catabolism", "orcin catabolism", "orcinol breakdown", "orcin catabolic process", "orcinol degradation"], "types": ["T044"], "canonical_name": "orcinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants. [GOC:jl]"}
{"concept_id": "C1154846", "aliases": ["p-cymene metabolism"], "types": ["T044"], "canonical_name": "p-cymene metabolic process", "definition": "The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants. [UM-BBD_pathwayID:pcy]"}
{"concept_id": "C1154847", "aliases": ["p-cymene breakdown", "p-cymene degradation", "p-cymene catabolism"], "types": ["T044"], "canonical_name": "p-cymene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants. [GOC:ai]"}
{"concept_id": "C1154848", "aliases": ["toluene degradation", "toluene breakdown", "toluene catabolism"], "types": ["T044"], "canonical_name": "toluene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products. [GOC:go_curators]"}
{"concept_id": "C1154849", "aliases": ["toluene-4-sulphonate catabolic process", "toluene-4-sulfonate catabolism", "toluene-4-sulphonate catabolism", "toluene-4-sulfonate breakdown", "4-toluenesulfonate catabolism", "toluene-4-sulfonate degradation", "4-toluenesulfonate catabolic process"], "types": ["T044"], "canonical_name": "toluene-4-sulfonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule. [GOC:ai]"}
{"concept_id": "C1154850", "aliases": [], "types": ["T044"], "canonical_name": "toluene oxidation", "definition": "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene. [GOC:mah]"}
{"concept_id": "C1154851", "aliases": [], "types": ["T044"], "canonical_name": "toluene oxidation to catechol", "definition": "The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2). [MetaCyc:TOLUENE-DEG-CATECHOL-PWY]"}
{"concept_id": "C1154852", "aliases": [], "types": ["T044"], "canonical_name": "toluene oxidation via 2-hydroxytoluene", "definition": "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol). [MetaCyc:TOLUENE-DEG-2-OH-PWY]"}
{"concept_id": "C1154853", "aliases": [], "types": ["T044"], "canonical_name": "toluene oxidation via 3-hydroxytoluene", "definition": "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol). [MetaCyc:TOLUENE-DEG-3-OH-PWY]"}
{"concept_id": "C1154854", "aliases": [], "types": ["T044"], "canonical_name": "toluene oxidation via 4-hydroxytoluene", "definition": "The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol). [MetaCyc:TOLUENE-DEG-4-OH-PWY]"}
{"concept_id": "C1154855", "aliases": [], "types": ["T044"], "canonical_name": "toluene oxidation via toluene-cis-1,2-dihydrodiol", "definition": "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol. [MetaCyc:TOLUENE-DEG-DIOL-PWY]"}
{"concept_id": "C1154856", "aliases": ["toluene-4-sulphonate metabolism", "4-methylbenzenesulfonate metabolism", "4-toluenesulfonate metabolic process", "4-methylbenzenesulfonate metabolic process", "4-toluenesulfonate metabolism", "toluene-4-sulphonate metabolic process", "toluene-4-sulfonate metabolism"], "types": ["T044"], "canonical_name": "toluene-4-sulfonate metabolic process", "definition": "The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water. [GOC:ai]"}
{"concept_id": "C1154857", "aliases": ["xylene metabolism"], "types": ["T044"], "canonical_name": "xylene metabolic process", "definition": "The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene. [GOC:jl]"}
{"concept_id": "C1154858", "aliases": ["m-xylene metabolism", "meta-xylene metabolic process", "meta-xylene metabolism"], "types": ["T044"], "canonical_name": "m-xylene metabolic process", "definition": "The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. [GOC:jl]"}
{"concept_id": "C1154859", "aliases": ["meta-xylene catabolism", "m-xylene degradation", "meta-xylene catabolic process", "m-xylene breakdown", "m-xylene catabolism"], "types": ["T044"], "canonical_name": "m-xylene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon. [GOC:go_curators, GOC:jl]"}
{"concept_id": "C1154860", "aliases": ["ortho-xylene metabolism", "ortho-xylene metabolic process", "o-xylene metabolism"], "types": ["T044"], "canonical_name": "o-xylene metabolic process", "definition": "The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. [GOC:jl]"}
{"concept_id": "C1154861", "aliases": ["o-xylene breakdown", "ortho-xylene catabolic process", "o-xylene degradation", "o-xylene catabolism", "ortho-xylene catabolism"], "types": ["T044"], "canonical_name": "o-xylene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. [GOC:jl]"}
{"concept_id": "C1154862", "aliases": ["p-xylene metabolism", "para-xylene metabolic process", "para-xylene metabolism"], "types": ["T044"], "canonical_name": "p-xylene metabolic process", "definition": "The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. [GOC:jl]"}
{"concept_id": "C1154863", "aliases": ["para-xylene catabolic process", "p-xylene degradation", "p-xylene breakdown", "para-xylene catabolism", "p-xylene catabolism"], "types": ["T044"], "canonical_name": "p-xylene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon. [GOC:jl]"}
{"concept_id": "C1154864", "aliases": ["xylene breakdown", "xylene degradation", "xylene catabolism"], "types": ["T044"], "canonical_name": "xylene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene. [GOC:go_curators]"}
{"concept_id": "C1154865", "aliases": ["caprolactam metabolism"], "types": ["T044"], "canonical_name": "caprolactam metabolic process", "definition": "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation. [GOC:curators]"}
{"concept_id": "C1154866", "aliases": ["caprolactam catabolism", "caprolactam breakdown", "caprolactam degradation"], "types": ["T044"], "canonical_name": "caprolactam catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid. [GOC:curators]"}
{"concept_id": "C1154867", "aliases": ["cyanamide metabolism"], "types": ["T044"], "canonical_name": "cyanamide metabolic process", "definition": "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism. [GOC:curators]"}
{"concept_id": "C1154868", "aliases": ["cyclohexanol metabolism"], "types": ["T044"], "canonical_name": "cyclohexanol metabolic process", "definition": "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent. [ISBN:0721662544]"}
{"concept_id": "C1154869", "aliases": [], "types": ["T044"], "canonical_name": "cyclohexanol oxidation", "definition": "The cyclohexanol metabolic process in which cyclohexanol is converted to adipate. [MetaCyc:CYCLOHEXANOL-OXIDATION-PWY]"}
{"concept_id": "C1154870", "aliases": ["cyclohexylsulphamate metabolism", "cyclohexylsulfamate metabolism", "cyclohexylsulphamate metabolic process"], "types": ["T044"], "canonical_name": "cyclohexylsulfamate metabolic process", "definition": "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide. [UM-BBD_pathwayID:chs]"}
{"concept_id": "C1154871", "aliases": ["dodecyl sulphate metabolism", "dodecyl sulphate metabolic process", "dodecyl sulfate metabolism"], "types": ["T044"], "canonical_name": "dodecyl sulfate metabolic process", "definition": "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants. [UM-BBD_pathwayID:dds]"}
{"concept_id": "C1154872", "aliases": ["halogenated hydrocarbon metabolism"], "types": ["T044"], "canonical_name": "halogenated hydrocarbon metabolic process", "definition": "The chemical reactions and pathways involving halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. Halogens include fluorine, chlorine, bromine and iodine. [GOC:ai, GOC:krc]"}
{"concept_id": "C1154873", "aliases": ["1,2,3-tribromopropane metabolism"], "types": ["T044"], "canonical_name": "1,2,3-tribromopropane metabolic process", "definition": "The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture. [GOC:jl]"}
{"concept_id": "C1154874", "aliases": ["chlorinated hydrocarbon metabolism"], "types": ["T044"], "canonical_name": "chlorinated hydrocarbon metabolic process", "definition": "The chemical reactions and pathways involving chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms. [GOC:ai, GOC:krc]"}
{"concept_id": "C1154875", "aliases": ["1,2-dichloroethane metabolism"], "types": ["T044"], "canonical_name": "1,2-dichloroethane metabolic process", "definition": "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride. [GOC:jl]"}
{"concept_id": "C1154876", "aliases": ["1,2-dichloroethane catabolism", "1,2-dichloroethane breakdown", "1,2-dichloroethane degradation"], "types": ["T044"], "canonical_name": "1,2-dichloroethane catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride. [GOC:go_curators]"}
{"concept_id": "C1154877", "aliases": ["1,3-dichloropropene metabolism", "gamma-chloroallylchloride metabolism", "1,3-dichloropropylene metabolism", "1,3-dichloropropylene metabolic process", "gamma-chloroallylchloride metabolic process"], "types": ["T044"], "canonical_name": "1,3-dichloropropene metabolic process", "definition": "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes. [UM-BBD_pathwayID:cpr]"}
{"concept_id": "C1154878", "aliases": ["3-chloroacrylic acid metabolism"], "types": ["T044"], "canonical_name": "3-chloroacrylic acid metabolic process", "definition": "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid. [GOC:ai]"}
{"concept_id": "C1154879", "aliases": ["atrazine metabolism"], "types": ["T044"], "canonical_name": "atrazine metabolic process", "definition": "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide. [UM-BBD_pathwayID:atr]"}
{"concept_id": "C1154880", "aliases": ["atrazine breakdown", "atrazine catabolism", "atrazine degradation"], "types": ["T044"], "canonical_name": "atrazine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide. [GOC:jl, UM-BBD_pathwayID:atr]"}
{"concept_id": "C1154881", "aliases": ["atrazine degradation to cyanuric acid", "atrazine breakdown to cyanuric acid"], "types": ["T044"], "canonical_name": "atrazine catabolic process to cyanuric acid", "definition": "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid. [GOC:jl]"}
{"concept_id": "C1154882", "aliases": ["atrazine degradation to isopropylamine", "atrazine breakdown to isopropylamine"], "types": ["T044"], "canonical_name": "atrazine catabolic process to isopropylamine", "definition": "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine. [GOC:jl]"}
{"concept_id": "C1154883", "aliases": ["atrazine breakdown to urea", "atrazine degradation to urea"], "types": ["T044"], "canonical_name": "atrazine catabolic process to urea", "definition": "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea. [GOC:jl]"}
{"concept_id": "C1154884", "aliases": ["carbon tetrachloride metabolism"], "types": ["T044"], "canonical_name": "carbon tetrachloride metabolic process", "definition": "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants. [UM-BBD_pathwayID:ctc]"}
{"concept_id": "C1154885", "aliases": ["anaerobic carbon tetrachloride metabolism"], "types": ["T044"], "canonical_name": "anaerobic carbon tetrachloride metabolic process", "definition": "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1154886", "aliases": ["carbon tetrachloride catabolism", "carbon tetrachloride degradation", "carbon tetrachloride breakdown"], "types": ["T044"], "canonical_name": "carbon tetrachloride catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants. [GOC:go_curators]"}
{"concept_id": "C1154887", "aliases": ["chlorinated hydrocarbon catabolism", "chlorinated hydrocarbon degradation", "chlorinated hydrocarbon breakdown"], "types": ["T044"], "canonical_name": "chlorinated hydrocarbon catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms. [GOC:ai, GOC:krc]"}
{"concept_id": "C1154888", "aliases": ["pentachlorophenol degradation", "pentachlorophenol breakdown", "pentachlorophenol catabolism"], "types": ["T044"], "canonical_name": "pentachlorophenol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms. [GOC:go_curators]"}
{"concept_id": "C1154889", "aliases": ["tetrachloroethene catabolism", "tetrachloroethylene breakdown", "tetrachloroethylene degradation", "tetrachloroethylene catabolism", "tetrachloroethene catabolic process"], "types": ["T044"], "canonical_name": "tetrachloroethylene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines. [GOC:ai]"}
{"concept_id": "C1154890", "aliases": ["dichloromethane metabolism"], "types": ["T044"], "canonical_name": "dichloromethane metabolic process", "definition": "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover. [UM-BBD_pathwayID:dcm]"}
{"concept_id": "C1154891", "aliases": ["hexachlorocyclohexane metabolism"], "types": ["T044"], "canonical_name": "hexachlorocyclohexane metabolic process", "definition": "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution. [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch]"}
{"concept_id": "C1154892", "aliases": ["beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism"], "types": ["T044"], "canonical_name": "beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process", "definition": "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health. [UM-BBD_pathwayID:hch]"}
{"concept_id": "C1154893", "aliases": ["aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism"], "types": ["T044"], "canonical_name": "aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process", "definition": "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen. [GOC:ai]"}
{"concept_id": "C1154894", "aliases": ["gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism"], "types": ["T044"], "canonical_name": "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process", "definition": "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health. [UM-BBD_pathwayID:ghch]"}
{"concept_id": "C1154895", "aliases": ["PCP metabolism", "PCP metabolic process", "pentachlorophenol metabolism"], "types": ["T044"], "canonical_name": "pentachlorophenol metabolic process", "definition": "The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms. [UM-BBD_pathwayID:pcp]"}
{"concept_id": "C1154896", "aliases": ["tetrachloroethylene metabolism", "tetrachloroethene metabolism", "tetrachloroethene metabolic process"], "types": ["T044"], "canonical_name": "tetrachloroethylene metabolic process", "definition": "The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent. [http://www.who.int/water_sanitation_health/GDWQ/Chemicals/tetrachloroethenesum.htm]"}
{"concept_id": "C1154897", "aliases": ["TCE metabolism", "TCE metabolic process", "trichloroethene metabolism", "trichloroethene metabolic process", "trichloroethylene metabolism"], "types": ["T044"], "canonical_name": "trichloroethylene metabolic process", "definition": "The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent. [GOC:jl]"}
{"concept_id": "C1154898", "aliases": ["halogenated hydrocarbon degradation", "halogenated hydrocarbon catabolism", "halogenated hydrocarbon breakdown"], "types": ["T044"], "canonical_name": "halogenated hydrocarbon catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. [GOC:ai, GOC:krc]"}
{"concept_id": "C1154899", "aliases": ["methyl fluoride metabolism"], "types": ["T044"], "canonical_name": "methyl fluoride metabolic process", "definition": "The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils. [UM-BBD_pathwayID:mf]"}
{"concept_id": "C1154900", "aliases": ["methanesulfonic acid metabolism", "methanesulphonic acid metabolic process", "methanesulphonic acid metabolism"], "types": ["T044"], "canonical_name": "methanesulfonic acid metabolic process", "definition": "The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide. [UM-BBD_pathwayID:msa]"}
{"concept_id": "C1154901", "aliases": ["MEK metabolism", "2-butanone metabolism", "MEK metabolic process", "2-butanone metabolic process", "methyl ethyl ketone metabolism"], "types": ["T044"], "canonical_name": "methyl ethyl ketone metabolic process", "definition": "The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints. [UM-BBD_pathwayID:mek]"}
{"concept_id": "C1154902", "aliases": ["methyl ethyl ketone breakdown", "methyl ethyl ketone degradation", "methyl ethyl ketone catabolism"], "types": ["T044"], "canonical_name": "methyl ethyl ketone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. [GOC:ai]"}
{"concept_id": "C1154903", "aliases": ["n-octane metabolism"], "types": ["T044"], "canonical_name": "n-octane metabolic process", "definition": "The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System. [UM-BBD_pathwayID:oct]"}
{"concept_id": "C1154904", "aliases": [], "types": ["T044"], "canonical_name": "n-octane oxidation", "definition": "The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA. [MetaCyc:P221-PWY]"}
{"concept_id": "C1154905", "aliases": ["nitrilotriacetate metabolism"], "types": ["T044"], "canonical_name": "nitrilotriacetate metabolic process", "definition": "The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment. [UM-BBD_pathwayID:nta]"}
{"concept_id": "C1154906", "aliases": ["aerobic nitrilotriacetate metabolism"], "types": ["T044"], "canonical_name": "aerobic nitrilotriacetate metabolic process", "definition": "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen. [GOC:ai]"}
{"concept_id": "C1154907", "aliases": ["anaerobic nitrilotriacetate metabolism"], "types": ["T044"], "canonical_name": "anaerobic nitrilotriacetate metabolic process", "definition": "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1154908", "aliases": ["nitroglycerin metabolism", "NG metabolic process", "NG metabolism"], "types": ["T044"], "canonical_name": "nitroglycerin metabolic process", "definition": "The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates. [UM-BBD_pathwayID:ng]"}
{"concept_id": "C1154909", "aliases": ["nylon metabolism"], "types": ["T044"], "canonical_name": "nylon metabolic process", "definition": "The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids. [UniProtKB-KW:KW-0549]"}
{"concept_id": "C1154910", "aliases": ["nylon breakdown", "nylon degradation", "nylon catabolism"], "types": ["T044"], "canonical_name": "nylon catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids. [UniProtKB-KW:KW-0549]"}
{"concept_id": "C1154911", "aliases": ["ether metabolism", "organic ether metabolism", "organic ether metabolic process"], "types": ["T044"], "canonical_name": "ether metabolic process", "definition": "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. [GOC:pr, ISBN:0198506732]"}
{"concept_id": "C1154912", "aliases": ["hydroxycineol metabolic process", "6-endo-hydroxycineole metabolic process", "6-endo-hydroxycineole metabolism", "6-hydroxycineole metabolism", "hydroxycineol metabolism"], "types": ["T044"], "canonical_name": "6-hydroxycineole metabolic process", "definition": "The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2. [GOC:ai]"}
{"concept_id": "C1154913", "aliases": ["6-hydroxycineole breakdown", "6-endo-hydroxycineole catabolism", "6-endo-hydroxycineole catabolic process", "6-hydroxycineole catabolism", "6-hydroxycineole degradation", "hydroxycineol catabolism", "hydroxycineol catabolic process"], "types": ["T044"], "canonical_name": "6-hydroxycineole catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2. [GOC:ai]"}
{"concept_id": "C1154914", "aliases": ["methyl ether metabolism", "dimethyl ether metabolism", "methyl ether metabolic process"], "types": ["T044"], "canonical_name": "dimethyl ether metabolic process", "definition": "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications. [UM-BBD_pathwayID:dme]"}
{"concept_id": "C1154915", "aliases": ["methyl tert-butyl ether metabolism"], "types": ["T044"], "canonical_name": "methyl tert-butyl ether metabolic process", "definition": "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent. [UM-BBD_pathwayID:mtb]"}
{"concept_id": "C1154916", "aliases": ["THF metabolism", "THF metabolic process", "tetrahydrofuran metabolism"], "types": ["T044"], "canonical_name": "tetrahydrofuran metabolic process", "definition": "The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems. [UM-BBD_pathwayID:thf]"}
{"concept_id": "C1154917", "aliases": ["organophosphate metabolism"], "types": ["T044"], "canonical_name": "organophosphate metabolic process", "definition": "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. [ISBN:0198506732]"}
{"concept_id": "C1154918", "aliases": ["glyphosate metabolism", "Roundup metabolism", "Roundup metabolic process"], "types": ["T044"], "canonical_name": "glyphosate metabolic process", "definition": "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond. [UM-BBD_pathwayID:gly]"}
{"concept_id": "C1154919", "aliases": ["organophosphate breakdown", "organophosphate degradation", "organophosphate catabolism"], "types": ["T044"], "canonical_name": "organophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. [GOC:ai]"}
{"concept_id": "C1154920", "aliases": ["organophosphonate catabolic process", "phosphonate degradation", "phosphonate breakdown", "phosphonate catabolism"], "types": ["T044"], "canonical_name": "organic phosphonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. [GOC:js]"}
{"concept_id": "C1154921", "aliases": ["2-phosphonoethylamine catabolism", "2-aminoethylphosphonate breakdown", "2-aminoethylphosphonate degradation", "2-aminoethylphosphonate catabolism", "2-phosphonoethylamine catabolic process", "ciliatine catabolism", "ciliatine catabolic process"], "types": ["T044"], "canonical_name": "2-aminoethylphosphonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine. [GOC:ai]"}
{"concept_id": "C1154922", "aliases": ["organophosphonate metabolic process", "phosphonate metabolism"], "types": ["T044"], "canonical_name": "organic phosphonate metabolic process", "definition": "The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. [GOC:js, ISBN:0721662544]"}
{"concept_id": "C1154923", "aliases": ["2-phosphonoethylamine metabolism", "ciliatine metabolism", "2-phosphonoethylamine metabolic process", "ciliatine metabolic process", "2-aminoethylphosphonate metabolism"], "types": ["T044"], "canonical_name": "2-aminoethylphosphonate metabolic process", "definition": "The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms. [GOC:ai, PMID:12107130]"}
{"concept_id": "C1154924", "aliases": ["phosphonoacetate metabolism"], "types": ["T044"], "canonical_name": "phosphonoacetate metabolic process", "definition": "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue. [MetaCyc:P483-PWY]"}
{"concept_id": "C1154925", "aliases": ["organosilicon metabolism", "organosilicone metabolism", "organosilicone metabolic process"], "types": ["T044"], "canonical_name": "organosilicon metabolic process", "definition": "The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon. [GOC:jl]"}
{"concept_id": "C1154926", "aliases": ["aerobic organosilicone metabolic process", "aerobic organosilicone metabolism", "aerobic organosilicon metabolism"], "types": ["T044"], "canonical_name": "aerobic organosilicon metabolic process", "definition": "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen. [GOC:jl]"}
{"concept_id": "C1154927", "aliases": ["dimethylsilanediol catabolism", "catabolic process of DMSD", "dimethylsilanediol breakdown", "degradation of dimethylsilanediol", "catabolism of DMSD", "dimethylsilanediol degradation"], "types": ["T044"], "canonical_name": "dimethylsilanediol catabolic process", "definition": "The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products. [GOC:jl]"}
{"concept_id": "C1154928", "aliases": ["anaerobic organosilicon metabolism", "anaerobic organosilicone metabolism", "anaerobic organosilicone metabolic process"], "types": ["T044"], "canonical_name": "anaerobic organosilicon metabolic process", "definition": "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen. [GOC:jl]"}
{"concept_id": "C1154929", "aliases": ["octamethylcyclotetrasiloxane degradation to dimethylsilanediol", "catabolism of octamethylcyclotetrasiloxane to DMSD", "catabolic process of octamethylcyclotetrasiloxane to DMSD", "octamethylcyclotetrasiloxane breakdown to dimethylsilanediol"], "types": ["T044"], "canonical_name": "octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter. [GOC:jl]"}
{"concept_id": "C1154930", "aliases": ["dimethylsilanediol metabolism"], "types": ["T044"], "canonical_name": "dimethylsilanediol metabolic process", "definition": "The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products. [GOC:ai]"}
{"concept_id": "C1154931", "aliases": ["octamethylcyclotetrasiloxane metabolism"], "types": ["T044"], "canonical_name": "octamethylcyclotetrasiloxane metabolic process", "definition": "The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom. [GOC:ai, http://chemfinder.cambridgesoft.com/]"}
{"concept_id": "C1154932", "aliases": ["octamethylcyclotetrasiloxane catabolism", "octamethylcyclotetrasiloxane breakdown", "octamethylcyclotetrasiloxane degradation"], "types": ["T044"], "canonical_name": "octamethylcyclotetrasiloxane catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom. [GOC:ai, PMID:10224038]"}
{"concept_id": "C1154933", "aliases": ["organosilicon catabolism", "organosilicone catabolic process", "organosilicon degradation", "organosilicon breakdown", "organosilicone catabolism"], "types": ["T044"], "canonical_name": "organosilicon catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon. [GOC:ai]"}
{"concept_id": "C1154934", "aliases": ["pentaerythritol tetranitrate metabolism"], "types": ["T044"], "canonical_name": "pentaerythritol tetranitrate metabolic process", "definition": "The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator. [UM-BBD_pathwayID:petn]"}
{"concept_id": "C1154935", "aliases": ["propylene metabolism"], "types": ["T044"], "canonical_name": "propylene metabolic process", "definition": "The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals. [GOC:jl]"}
{"concept_id": "C1154936", "aliases": ["propylene breakdown", "propylene catabolism", "propylene degradation"], "types": ["T044"], "canonical_name": "propylene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. [GOC:jl]"}
{"concept_id": "C1154937", "aliases": ["s-triazine compound metabolism"], "types": ["T044"], "canonical_name": "s-triazine compound metabolic process", "definition": "The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms. [UM-BBD_pathwayID:tria]"}
{"concept_id": "C1154938", "aliases": ["cyanuric acid metabolism"], "types": ["T044"], "canonical_name": "cyanuric acid metabolic process", "definition": "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives. [UM-BBD_pathwayID:cya]"}
{"concept_id": "C1154939", "aliases": ["cyanuric acid breakdown", "cyanuric acid catabolism", "cyanuric acid degradation"], "types": ["T044"], "canonical_name": "cyanuric acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides. [UM-BBD_pathwayID:cya]"}
{"concept_id": "C1154940", "aliases": ["N-cyclopropylmelamine metabolism", "cyromazine metabolism", "cyromazine metabolic process"], "types": ["T044"], "canonical_name": "N-cyclopropylmelamine metabolic process", "definition": "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide. [UM-BBD_pathwayID:cpm]"}
{"concept_id": "C1154941", "aliases": ["N-cyclopropylmelamine catabolism", "N-cyclopropylmelamine breakdown", "N-cyclopropylmelamine degradation", "cyromazine catabolic process", "cyromazine catabolism"], "types": ["T044"], "canonical_name": "N-cyclopropylmelamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide. [UM-BBD_pathwayID:cpm]"}
{"concept_id": "C1154942", "aliases": ["s-triazine compound breakdown", "s-triazine compound degradation", "s-triazine compound catabolism"], "types": ["T044"], "canonical_name": "s-triazine compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms. [UM-BBD_pathwayID:tria]"}
{"concept_id": "C1154943", "aliases": ["thiocyanic acid metabolism", "thiocyanic acid metabolic process", "thiocyanate metabolism"], "types": ["T044"], "canonical_name": "thiocyanate metabolic process", "definition": "The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries. [GOC:jl]"}
{"concept_id": "C1154944", "aliases": ["thiocyanate catabolism", "thiocyanate breakdown", "thiocyanate degradation"], "types": ["T044"], "canonical_name": "thiocyanate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid. [GOC:ai]"}
{"concept_id": "C1154945", "aliases": ["triethanolamine metabolism"], "types": ["T044"], "canonical_name": "triethanolamine metabolic process", "definition": "The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. [GOC:jl]"}
{"concept_id": "C1154946", "aliases": ["triethanolamine breakdown", "triethanolamine catabolism", "triethanolamine degradation"], "types": ["T044"], "canonical_name": "triethanolamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. [GOC:ai]"}
{"concept_id": "C1154947", "aliases": ["xenobiotic catabolism", "xenobiotic degradation", "xenobiotic breakdown"], "types": ["T043"], "canonical_name": "xenobiotic catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]"}
{"concept_id": "C1154948", "aliases": ["1-aminocyclopropane-1-carboxylate catabolism", "1-aminocyclopropane-1-carboxylate degradation", "1-aminocyclopropane-1-carboxylate breakdown"], "types": ["T044"], "canonical_name": "1-aminocyclopropane-1-carboxylate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. [GOC:go_curators]"}
{"concept_id": "C1154949", "aliases": ["response to gravitational stimulus"], "types": ["T043"], "canonical_name": "response to gravity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. [GOC:hb]"}
{"concept_id": "C1154951", "aliases": ["hypertonic response", "HOG response", "response to hypertonicity"], "types": ["T043"], "canonical_name": "hyperosmotic response", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. [GOC:jl, PMID:12142009]"}
{"concept_id": "C1154952", "aliases": ["hyperosmotic salinity response"], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:jl]", "canonical_name": "response to hyperosmotic salt stress"}
{"concept_id": "C1154953", "aliases": [], "types": ["T043"], "canonical_name": "intracellular accumulation of glycerol", "definition": "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment. [GOC:jl, PMID:11752666]"}
{"concept_id": "C1154954", "aliases": ["hypo-osmotic response"], "types": ["T043"], "canonical_name": "hypotonic response", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. [GOC:jl, PMID:12598593]"}
{"concept_id": "C1154955", "aliases": ["response to hypotonic salt stress"], "types": ["T043"], "canonical_name": "hypotonic salinity response", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:jl]"}
{"concept_id": "C1154956", "aliases": ["response to ionic osmotic stress", "salinity response", "response to salt stress"], "types": ["T039"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:jl]", "canonical_name": "response to salinity"}
{"concept_id": "C1154957", "aliases": [], "types": ["T040"], "canonical_name": "response to pH", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:jl, Wikipedia:PH]"}
{"concept_id": "C1154958", "aliases": ["response to radiation stimulus", "response to radiation"], "types": ["T038"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. [GOC:jl, Wikipedia:Electromagnetic_radiation]", "canonical_name": "response to electromagnetic radiation stimulus"}
{"concept_id": "C1154960", "aliases": ["response to blue light stimulus"], "types": ["T043"], "canonical_name": "response to blue light", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. [GOC:ai, GOC:mtg_far_red]"}
{"concept_id": "C1154961", "aliases": [], "types": ["T040"], "canonical_name": "response to light intensity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus. [GOC:go_curators]"}
{"concept_id": "C1154962", "aliases": ["photoacclimation", "light acclimatization"], "types": ["T040"], "canonical_name": "photosynthetic acclimation", "definition": "A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light. [GOC:mah, PMID:11069694]"}
{"concept_id": "C1154963", "aliases": ["response to darkness"], "types": ["T040"], "canonical_name": "response to absence of light", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli. [GOC:go_curators]"}
{"concept_id": "C1154964", "aliases": [], "types": ["T040"], "definition": "Physical changes in the growth patterns of a plant brought on by sustained absence of light. These changes are characterized by lengthened internodes which produce long weak stems, fewer leaves, and pale yellow color (chlorosis). The physiological basis for etiolation is induction of the phytohormone, AUXIN.", "canonical_name": "etiolation"}
{"concept_id": "C1154965", "aliases": [], "types": ["T040"], "canonical_name": "response to high light intensity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. [GOC:go_curators]"}
{"concept_id": "C1154966", "aliases": [], "types": ["T040"], "canonical_name": "response to low light intensity stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2. [GOC:go_curators, GOC:mtg_far_red]"}
{"concept_id": "C1154967", "aliases": ["response to day length", "response to photoperiod", "response to night length"], "types": ["T040"], "canonical_name": "photoperiodism", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1154968", "aliases": [], "types": ["T043"], "canonical_name": "response to photoperiod, blue light", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. [GOC:go_curators, GOC:mtg_far_red]"}
{"concept_id": "C1154969", "aliases": [], "types": ["T043"], "canonical_name": "response to photoperiod, red light", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. [GOC:go_curators, GOC:mtg_far_red]"}
{"concept_id": "C1154970", "aliases": [], "types": ["T039"], "canonical_name": "response to red or far red light", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. [GOC:ai, GOC:mtg_far_red]"}
{"concept_id": "C1154971", "aliases": ["plant development in response to light"], "types": ["T039"], "canonical_name": "photomorphogenesis", "definition": "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis. [GOC:lr]"}
{"concept_id": "C1154972", "aliases": [], "types": ["T040"], "definition": "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll. [GOC:lr]", "canonical_name": "de-etiolation"}
{"concept_id": "C1154973", "aliases": [], "types": ["T039"], "canonical_name": "shade avoidance", "definition": "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome. [Wikipedia:Shade_avoidance]"}
{"concept_id": "C1154974", "aliases": ["response to ultraviolet radiation stimulus", "response to UV radiation stimulus", "response to ultraviolet light stimulus", "response to UV light stimulus"], "types": ["T038"], "canonical_name": "response to UV", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:hb]"}
{"concept_id": "C1154975", "aliases": ["UV protection"], "types": ["T043"], "definition": "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. [GOC:jl, GOC:ml]", "canonical_name": "ultraviolet protection"}
{"concept_id": "C1154977", "aliases": [], "types": ["T038"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:lr]", "canonical_name": "response to cold"}
{"concept_id": "C1154978", "aliases": [], "types": ["T040"], "canonical_name": "cold acclimation", "definition": "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures. [GOC:syr]"}
{"concept_id": "C1154981", "aliases": ["response to drought", "response to thirst", "response to dehydration"], "types": ["T040"], "canonical_name": "response to water deprivation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. [GOC:lr]"}
{"concept_id": "C1154982", "aliases": [], "types": ["T040"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition. [GOC:lr]", "canonical_name": "drought recovery"}
{"concept_id": "C1154984", "aliases": [], "types": ["T040"], "canonical_name": "response to flooding", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water. [GOC:lr]"}
{"concept_id": "C1154985", "aliases": [], "types": ["T040"], "canonical_name": "response to humidity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere. [GOC:jl]"}
{"concept_id": "C1154986", "aliases": [], "types": ["T040"], "canonical_name": "response to biotic stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. [GOC:hb]"}
{"concept_id": "C1154988", "aliases": ["physiological defense response", "defence response"], "types": ["T040"], "canonical_name": "defense response", "definition": "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. [GOC:go_curators]"}
{"concept_id": "C1154990", "aliases": ["antigen presentation, endogenous antigen"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous antigen", "definition": "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]"}
{"concept_id": "C1154991", "aliases": ["endogenous lipid antigen processing and presentation via MHC class Ib", "antigen presentation, endogenous lipid antigen"], "types": ["T043"], "canonical_name": "antigen processing and presentation, endogenous lipid antigen via MHC class Ib", "definition": "The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]"}
{"concept_id": "C1154993", "aliases": ["antigen presentation, exogenous antigen"], "types": ["T043"], "canonical_name": "antigen processing and presentation of exogenous antigen", "definition": "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]"}
{"concept_id": "C1154996", "aliases": ["lipid antigen processing and presentation via MHC class Ib", "antigen presentation, lipid antigen"], "types": ["T043"], "canonical_name": "antigen processing and presentation of lipid antigen via MHC class Ib", "definition": "The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]"}
{"concept_id": "C1154997", "aliases": ["peptide antigen processing and presentation", "antigen presentation, peptide antigen"], "types": ["T043"], "canonical_name": "antigen processing and presentation of peptide antigen", "definition": "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1154998", "aliases": ["antigen processing, endogenous antigen via major histocompatibility complex class I"], "types": ["T043"], "canonical_name": "antigen processing, endogenous antigen via MHC class I"}
{"concept_id": "C1154999", "aliases": [], "types": ["T043"], "canonical_name": "antigen processing, exogenous antigen via major histocompatibility complex class II"}
{"concept_id": "C1155000", "aliases": ["immune cell activation", "leucocyte activation"], "types": ["T043"], "definition": "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. [GOC:add]", "canonical_name": "leukocyte activation"}
{"concept_id": "C1155001", "aliases": [], "types": ["T043"], "canonical_name": "basophil activation", "definition": "The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors. [GOC:mgi_curators, ISBN:0781735149]"}
{"concept_id": "C1155002", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell activation", "definition": "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484]"}
{"concept_id": "C1155003", "aliases": ["B cell activation", "B-cell activation", "B-lymphocyte activation"], "types": ["T043"], "definition": "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]", "canonical_name": "B lymphocyte activation"}
{"concept_id": "C1155005", "aliases": ["regulation of B lymphocyte differentiation", "regulation of B-cell differentiation", "regulation of B-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of B cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of B cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155006", "aliases": ["down-regulation of B cell differentiation", "negative regulation of B lymphocyte differentiation", "negative regulation of B-lymphocyte differentiation", "downregulation of B cell differentiation", "down regulation of B cell differentiation", "negative regulation of B-cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of B cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155007", "aliases": ["positive regulation of B-cell differentiation", "upregulation of B cell differentiation", "positive regulation of B-lymphocyte differentiation", "up regulation of B cell differentiation", "positive regulation of B lymphocyte differentiation", "up-regulation of B cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of B cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of B cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155008", "aliases": ["B-cell proliferation", "B cell proliferation", "B-lymphocyte proliferation"], "types": ["T043"], "definition": "The expansion of a B cell population by cell division. Follows B cell activation. [GOC:jl]", "canonical_name": "B lymphocyte proliferation"}
{"concept_id": "C1155009", "aliases": ["regulation of class switching", "regulation of class switch recombination", "regulation of isotype switch recombination"], "types": ["T043"], "canonical_name": "regulation of isotype switching", "definition": "Any process that modulates the frequency, rate or extent of isotype switching. [GOC:ai]"}
{"concept_id": "C1155010", "aliases": ["negative regulation of class switch recombination", "downregulation of isotype switching", "down-regulation of isotype switching", "negative regulation of isotype switch recombination", "negative regulation of class switching", "down regulation of isotype switching"], "types": ["T043"], "canonical_name": "negative regulation of isotype switching", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching. [GOC:go_curators]"}
{"concept_id": "C1155011", "aliases": ["positive regulation of class switching", "positive regulation of isotype switch recombination", "positive regulation of class switch recombination", "upregulation of isotype switching", "up-regulation of isotype switching", "up regulation of isotype switching"], "types": ["T043"], "canonical_name": "positive regulation of isotype switching", "definition": "Any process that activates or increases the frequency, rate or extent of isotype switching. [GOC:go_curators]"}
{"concept_id": "C1155013", "aliases": ["T lymphocyte differentiation", "T cell differentiation", "T-cell differentiation"], "types": ["T043"], "definition": "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. [GO_REF:0000022, GOC:jid, GOC:mah]", "canonical_name": "T-lymphocyte differentiation"}
{"concept_id": "C1155014", "aliases": ["alpha-beta T-cell differentiation", "alpha-beta T lymphocyte differentiation", "alpha-beta T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "alpha-beta T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. [CL:0000789, GOC:ai]"}
{"concept_id": "C1155015", "aliases": ["regulation of alpha-beta T-lymphocyte differentiation", "regulation of alpha-beta T-cell differentiation", "regulation of alpha-beta T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of alpha-beta T cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. [GOC:ai]"}
{"concept_id": "C1155016", "aliases": ["negative regulation of alpha-beta T lymphocyte differentiation", "down regulation of alpha-beta T cell differentiation", "downregulation of alpha-beta T cell differentiation", "down-regulation of alpha-beta T cell differentiation", "negative regulation of alpha-beta T-lymphocyte differentiation", "negative regulation of alpha-beta T-cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of alpha-beta T cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation. [GOC:ai]"}
{"concept_id": "C1155017", "aliases": ["positive regulation of alpha-beta T-lymphocyte differentiation", "up regulation of alpha-beta T cell differentiation", "positive regulation of alpha-beta T-cell differentiation", "up-regulation of alpha-beta T cell differentiation", "upregulation of alpha-beta T cell differentiation", "positive regulation of alpha-beta T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of alpha-beta T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. [GOC:ai]"}
{"concept_id": "C1155018", "aliases": ["cytotoxic T lymphocyte selection", "cytotoxic T-lymphocyte selection", "cytotoxic T-cell selection"], "types": ["T043"], "canonical_name": "cytotoxic T cell differentiation", "definition": "The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell. [GOC:ai]"}
{"concept_id": "C1155019", "aliases": ["regulation of cytotoxic T lymphocyte differentiation", "regulation of cytotoxic T-cell differentiation", "regulation of cytotoxic T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of cytotoxic T cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155020", "aliases": ["down regulation of cytotoxic T cell differentiation", "negative regulation of cytotoxic T lymphocyte differentiation", "downregulation of cytotoxic T cell differentiation", "negative regulation of cytotoxic T-lymphocyte differentiation", "negative regulation of cytotoxic T-cell differentiation", "down-regulation of cytotoxic T cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of cytotoxic T cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155021", "aliases": ["upregulation of cytotoxic T cell differentiation", "positive regulation of cytotoxic T-cell differentiation", "up-regulation of cytotoxic T cell differentiation", "positive regulation of cytotoxic T lymphocyte differentiation", "up regulation of cytotoxic T cell differentiation", "positive regulation of cytotoxic T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of cytotoxic T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155022", "aliases": ["gamma-delta T lymphocyte differentiation", "gamma-delta T-lymphocyte differentiation", "gamma-delta T-cell differentiation"], "types": ["T043"], "canonical_name": "gamma-delta T cell differentiation", "definition": "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex. [CL:0000798, GOC:jl]"}
{"concept_id": "C1155023", "aliases": ["regulation of gamma-delta T-cell differentiation", "regulation of gamma-delta T lymphocyte differentiation", "regulation of gamma-delta T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of gamma-delta T cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155024", "aliases": ["negative regulation of gamma-delta T-cell differentiation", "down-regulation of gamma-delta T cell differentiation", "negative regulation of gamma-delta T-lymphocyte differentiation", "downregulation of gamma-delta T cell differentiation", "negative regulation of gamma-delta T lymphocyte differentiation", "down regulation of gamma-delta T cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of gamma-delta T cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155025", "aliases": ["positive regulation of gamma-delta T-cell differentiation", "upregulation of gamma-delta T cell differentiation", "positive regulation of gamma-delta T-lymphocyte differentiation", "up-regulation of gamma-delta T cell differentiation", "up regulation of gamma-delta T cell differentiation", "positive regulation of gamma-delta T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of gamma-delta T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155026", "aliases": ["regulation of T-cell differentiation", "regulation of T-lymphocyte differentiation", "regulation of T cell development", "regulation of T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of T cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of T cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155027", "aliases": ["down regulation of T cell differentiation", "downregulation of T cell differentiation", "negative regulation of T-cell differentiation", "negative regulation of T-lymphocyte differentiation", "down-regulation of T cell differentiation", "negative regulation of T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of T cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155028", "aliases": ["negative regulation of regulatory T lymphocyte differentiation", "down-regulation of regulatory T cell differentiation", "negative regulation of suppressor T cell differentiation", "negative regulation of regulatory T-cell differentiation", "downregulation of regulatory T cell differentiation", "down regulation of regulatory T cell differentiation", "negative regulation of suppressor T-cell differentiation", "negative regulation of regulatory T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of regulatory T cell differentiation", "definition": "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells. [ISBN:0781735149]"}
{"concept_id": "C1155029", "aliases": ["downregulation of T-helper cell differentiation", "down-regulation of T-helper cell differentiation", "down regulation of T-helper cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of T-helper cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155030", "aliases": ["down regulation of T-helper 1 cell differentiation", "down-regulation of T-helper 1 cell differentiation", "downregulation of T-helper 1 cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of T-helper 1 cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155031", "aliases": ["down-regulation of T-helper 2 cell differentiation", "downregulation of T-helper 2 cell differentiation", "down regulation of T-helper 2 cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of T-helper 2 cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155032", "aliases": ["up-regulation of T cell differentiation", "up regulation of T cell differentiation", "positive regulation of T lymphocyte differentiation", "positive regulation of T-lymphocyte differentiation", "upregulation of T cell differentiation", "positive regulation of T-cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of T cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155033", "aliases": ["positive regulation of regulatory T lymphocyte differentiation", "upregulation of regulatory T cell differentiation", "positive regulation of regulatory T-cell differentiation", "up-regulation of regulatory T cell differentiation", "positive regulation of suppressor T cell differentiation", "positive regulation of suppressor T-cell differentiation", "positive regulation of regulatory T-lymphocyte differentiation", "up regulation of regulatory T cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of regulatory T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells. [ISBN:0781735149]"}
{"concept_id": "C1155034", "aliases": ["upregulation of T-helper cell differentiation", "up regulation of T-helper cell differentiation", "up-regulation of T-helper cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of T-helper cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155035", "aliases": ["up-regulation of T-helper 1 cell differentiation", "upregulation of T-helper 1 cell differentiation", "up regulation of T-helper 1 cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of T-helper 1 cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155036", "aliases": ["upregulation of T-helper 2 cell differentiation", "up regulation of T-helper 2 cell differentiation", "up-regulation of T-helper 2 cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of T-helper 2 cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155037", "aliases": ["regulation of suppressor T-lymphocyte differentiation", "regulation of suppressor T-cell differentiation", "regulation of suppressor T lymphocyte differentiation", "regulation of regulatory T-lymphocyte differentiation", "regulation of regulatory T-cell differentiation", "regulation of suppressor T cell differentiation", "regulation of regulatory T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of regulatory T cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. [ISBN:0781735149]"}
{"concept_id": "C1155038", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T-helper cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of T-helper cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155039", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T-helper 1 cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155040", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T-helper 2 cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155041", "aliases": ["suppressor T-cell differentiation", "suppressor T lymphocyte differentiation", "regulatory T-cell differentiation", "suppressor T cell differentiation", "suppressor T-lymphocyte differentiation", "regulatory T lymphocyte differentiation", "regulatory T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulatory T cell differentiation", "definition": "The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types. [ISBN:0781735149]"}
{"concept_id": "C1155042", "aliases": ["helper T cell differentiation"], "types": ["T043"], "canonical_name": "T-helper cell differentiation", "definition": "The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. [GOC:ebc]"}
{"concept_id": "C1155043", "aliases": ["T-helper 1 cell development"], "types": ["T043"], "canonical_name": "T-helper 1 cell differentiation", "definition": "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. [CL:0000545, GOC:ebc]"}
{"concept_id": "C1155044", "aliases": ["T-helper 2 cell development"], "types": ["T043"], "canonical_name": "T-helper 2 cell differentiation", "definition": "The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4. [CL:0000546, GOC:ebc]"}
{"concept_id": "C1155046", "aliases": ["T-lymphocyte proliferation", "T cell proliferation", "T-cell proliferation"], "types": ["T043"], "definition": "The expansion of a T cell population by cell division. Follows T cell activation. [GOC:jl]", "canonical_name": "T lymphocyte proliferation"}
{"concept_id": "C1155047", "aliases": ["alpha-beta T-lymphocyte proliferation", "alpha-beta T-cell proliferation", "alpha-beta T lymphocyte proliferation"], "types": ["T043"], "canonical_name": "alpha-beta T cell proliferation", "definition": "The expansion of an alpha-beta T cell population by cell division. [GOC:ai]"}
{"concept_id": "C1155048", "aliases": ["regulation of alpha-beta T lymphocyte proliferation", "regulation of alpha-beta T-cell proliferation", "regulation of alpha-beta T-lymphocyte proliferation"], "types": ["T043"], "canonical_name": "regulation of alpha-beta T cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation. [GOC:ai]"}
{"concept_id": "C1155049", "aliases": ["negative regulation of alpha-beta T-cell proliferation", "negative regulation of alpha-beta T lymphocyte proliferation", "down regulation of alpha-beta T cell proliferation", "downregulation of alpha-beta T cell proliferation", "negative regulation of alpha-beta T-lymphocyte proliferation", "down-regulation of alpha-beta T cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of alpha-beta T cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation. [GOC:ai]"}
{"concept_id": "C1155050", "aliases": ["positive regulation of alpha-beta T lymphocyte proliferation", "up regulation of alpha-beta T cell proliferation", "positive regulation of alpha-beta T-cell proliferation", "upregulation of alpha-beta T cell proliferation", "positive regulation of alpha-beta T-lymphocyte proliferation", "up-regulation of alpha-beta T cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of alpha-beta T cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. [GOC:ai]"}
{"concept_id": "C1155051", "aliases": ["gamma-delta T-lymphocyte proliferation", "gamma-delta T lymphocyte proliferation", "gamma-delta T-cell proliferation"], "types": ["T043"], "canonical_name": "gamma-delta T cell proliferation", "definition": "The expansion of a gamma-delta T cell population by cell division. [GOC:ai]"}
{"concept_id": "C1155052", "aliases": ["regulation of gamma-delta T-lymphocyte proliferation", "regulation of gamma-delta T lymphocyte proliferation", "regulation of gamma-delta T-cell proliferation"], "types": ["T043"], "canonical_name": "regulation of gamma-delta T cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation. [GOC:ai]"}
{"concept_id": "C1155053", "aliases": ["down regulation of gamma-delta T cell proliferation", "negative regulation of gamma-delta T-cell proliferation", "negative regulation of gamma-delta T-lymphocyte proliferation", "down-regulation of gamma-delta T cell proliferation", "negative regulation of gamma-delta T lymphocyte proliferation", "downregulation of gamma-delta T cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of gamma-delta T cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation. [GOC:ai]"}
{"concept_id": "C1155054", "aliases": ["upregulation of gamma-delta T cell proliferation", "up-regulation of gamma-delta T cell proliferation", "up regulation of gamma-delta T cell proliferation", "positive regulation of gamma-delta T-cell proliferation", "positive regulation of gamma-delta T lymphocyte proliferation", "positive regulation of gamma-delta T-lymphocyte proliferation"], "types": ["T043"], "canonical_name": "positive regulation of gamma-delta T cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation. [GOC:ai]"}
{"concept_id": "C1155055", "aliases": ["regulation of T-cell proliferation", "regulation of T lymphocyte proliferation", "regulation of T-lymphocyte proliferation"], "types": ["T043"], "canonical_name": "regulation of T cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of T cell proliferation. [GOC:jl]"}
{"concept_id": "C1155056", "aliases": ["negative regulation of T-cell proliferation", "down regulation of T cell proliferation", "negative regulation of T lymphocyte proliferation", "downregulation of T cell proliferation", "down-regulation of T cell proliferation", "negative regulation of T-lymphocyte proliferation"], "types": ["T043"], "canonical_name": "negative regulation of T cell proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of T cell proliferation. [GOC:jl]"}
{"concept_id": "C1155057", "aliases": ["down-regulation of activated T cell proliferation", "down regulation of activated T cell proliferation", "negative regulation of activated T-lymphocyte proliferation", "negative regulation of activated T lymphocyte proliferation", "downregulation of activated T cell proliferation", "negative regulation of activated T-cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of activated T cell proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation. [GOC:go_curators]"}
{"concept_id": "C1155058", "aliases": ["down regulation of T cell homeostatic proliferation", "downregulation of T cell homeostatic proliferation", "negative regulation of T-lymphocyte homeostatic proliferation", "negative regulation of T lymphocyte homeostatic proliferation", "negative regulation of resting T cell proliferation", "negative regulation of T-cell homeostatic proliferation", "down-regulation of T cell homeostatic proliferation"], "types": ["T043"], "canonical_name": "negative regulation of T cell homeostatic proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation. [GOC:go_curators]"}
{"concept_id": "C1155059", "aliases": ["positive regulation of T lymphocyte proliferation", "up regulation of T cell proliferation", "upregulation of T cell proliferation", "positive regulation of T-lymphocyte proliferation", "up-regulation of T cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of T cell proliferation", "definition": "Any process that activates or increases the rate or extent of T cell proliferation. [GOC:ai]"}
{"concept_id": "C1155060", "aliases": ["positive regulation of activated T-lymphocyte proliferation", "up regulation of activated T cell proliferation", "up-regulation of activated T cell proliferation", "positive regulation of activated T-cell proliferation", "upregulation of activated T cell proliferation", "positive regulation of activated T lymphocyte proliferation"], "types": ["T043"], "canonical_name": "positive regulation of activated T cell proliferation", "definition": "Any process that activates or increases the rate or extent of activated T cell proliferation. [GOC:jl]"}
{"concept_id": "C1155061", "aliases": ["positive regulation of T-lymphocyte homeostatic proliferation", "positive regulation of T lymphocyte homeostatic proliferation", "up regulation of T cell homeostatic proliferation", "upregulation of T cell homeostatic proliferation", "positive regulation of T-cell homeostatic proliferation", "positive regulation of resting T cell proliferation", "up-regulation of T cell homeostatic proliferation"], "types": ["T043"], "canonical_name": "positive regulation of T cell homeostatic proliferation", "definition": "Any process that activates or increases the rate or extent of resting T cell proliferation. [GOC:jl]"}
{"concept_id": "C1155062", "aliases": ["regulation of activated T-lymphocyte proliferation", "regulation of activated T-cell proliferation", "regulation of activated T lymphocyte proliferation"], "types": ["T043"], "canonical_name": "regulation of activated T cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of activated T cell proliferation. [GOC:go_curators]"}
{"concept_id": "C1155063", "aliases": ["regulation of T lymphocyte homeostatic proliferation", "regulation of T-cell homeostatic proliferation", "regulation of T-lymphocyte homeostatic proliferation", "regulation of resting T cell proliferation"], "types": ["T043"], "canonical_name": "regulation of T cell homeostatic proliferation", "definition": "Any process that modulates the frequency, rate or extent of resting T cell proliferation. [GOC:go_curators]"}
{"concept_id": "C1155064", "aliases": ["natural killer cell activation"], "types": ["T043"], "definition": "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]", "canonical_name": "NK cell activation"}
{"concept_id": "C1155065", "aliases": ["T-cell activation", "T cell activation", "T-lymphocyte activation"], "types": ["T043"], "definition": "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]", "canonical_name": "T lymphocyte activation"}
{"concept_id": "C1155066", "aliases": ["alpha-beta T-lymphocyte activation", "alpha-beta T-cell activation", "alpha-beta T lymphocyte activation"], "types": ["T043"], "canonical_name": "alpha-beta T cell activation", "definition": "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:add]"}
{"concept_id": "C1155067", "aliases": ["regulation of alpha-beta T-cell activation", "regulation of alpha-beta T lymphocyte activation", "regulation of alpha-beta T-lymphocyte activation"], "types": ["T043"], "canonical_name": "regulation of alpha-beta T cell activation", "definition": "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. [GOC:ai]"}
{"concept_id": "C1155068", "aliases": ["negative regulation of alpha-beta T lymphocyte activation", "down-regulation of alpha-beta T cell activation", "downregulation of alpha-beta T cell activation", "negative regulation of alpha-beta T-cell activation", "down regulation of alpha-beta T cell activation", "negative regulation of alpha-beta T-lymphocyte activation"], "types": ["T043"], "canonical_name": "negative regulation of alpha-beta T cell activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. [GOC:ai]"}
{"concept_id": "C1155069", "aliases": ["up-regulation of alpha-beta T cell activation", "up regulation of alpha-beta T cell activation", "positive regulation of alpha-beta T-cell activation", "upregulation of alpha-beta T cell activation", "positive regulation of alpha-beta T-lymphocyte activation", "positive regulation of alpha-beta T lymphocyte activation"], "types": ["T043"], "canonical_name": "positive regulation of alpha-beta T cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. [GOC:ai]"}
{"concept_id": "C1155070", "aliases": ["gamma-delta T lymphocyte activation", "gamma-delta T-lymphocyte activation", "gamma-delta T-cell activation"], "types": ["T043"], "canonical_name": "gamma-delta T cell activation", "definition": "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:add]"}
{"concept_id": "C1155071", "aliases": ["regulation of gamma-delta T-lymphocyte activation", "regulation of gamma-delta T-cell activation", "regulation of gamma-delta T lymphocyte activation"], "types": ["T043"], "canonical_name": "regulation of gamma-delta T cell activation", "definition": "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation. [GOC:ai]"}
{"concept_id": "C1155072", "aliases": ["downregulation of gamma-delta T cell activation", "negative regulation of gamma-delta T lymphocyte activation", "down-regulation of gamma-delta T cell activation", "negative regulation of gamma-delta T-cell activation", "negative regulation of gamma-delta T-lymphocyte activation", "down regulation of gamma-delta T cell activation"], "types": ["T043"], "canonical_name": "negative regulation of gamma-delta T cell activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation. [GOC:ai]"}
{"concept_id": "C1155073", "aliases": ["up-regulation of gamma-delta T cell activation", "positive regulation of gamma-delta T-cell activation", "positive regulation of gamma-delta T lymphocyte activation", "positive regulation of gamma-delta T-lymphocyte activation", "upregulation of gamma-delta T cell activation", "up regulation of gamma-delta T cell activation"], "types": ["T043"], "canonical_name": "positive regulation of gamma-delta T cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation. [GOC:ai]"}
{"concept_id": "C1155074", "aliases": [], "types": ["T043"], "definition": "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. [GOC:mgi_curators, ISBN:0781735149]", "canonical_name": "mast cell activation"}
{"concept_id": "C1155075", "aliases": [], "types": ["T043"], "canonical_name": "monocyte activation", "definition": "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]"}
{"concept_id": "C1155076", "aliases": ["cellular defence response"], "types": ["T043"], "canonical_name": "cellular defense response", "definition": "A defense response that is mediated by cells. [GOC:ebc]"}
{"concept_id": "C1155080", "aliases": ["Th1 immune response"], "types": ["T043"], "canonical_name": "T-helper 1 type immune response", "definition": "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1155229", "aliases": [], "types": ["T043"], "definition": "An immune response mediated through a body fluid. [GOC:hb, ISBN:0198506732]", "canonical_name": "humoral immune response"}
{"concept_id": "C1155230", "aliases": [], "types": ["T043"], "canonical_name": "antimicrobial humoral response", "definition": "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1155231", "aliases": [], "types": ["T043"], "canonical_name": "antibacterial humoral response", "definition": "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1155234", "aliases": ["up regulation of antibacterial peptide biosynthetic process", "upregulation of antibacterial peptide biosynthetic process", "up-regulation of antibacterial peptide biosynthetic process", "antibacterial peptide induction", "antibacterial polypeptide induction"], "types": ["T044"], "canonical_name": "positive regulation of antibacterial peptide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis. [GOC:mah, PMID:10973475]"}
{"concept_id": "C1155235", "aliases": ["upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "anti-Gram-negative bacterial peptide induction", "anti-Gram-negative bacterial polypeptide induction", "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria"], "types": ["T044"], "canonical_name": "positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "definition": "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria. [GOC:mah, PMID:10973475]"}
{"concept_id": "C1155236", "aliases": ["anti-Gram-positive bacterial polypeptide induction", "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "anti-Gram-positive bacterial peptide induction"], "types": ["T044"], "canonical_name": "positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "definition": "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria. [GOC:mah, PMID:10973475]"}
{"concept_id": "C1155237", "aliases": [], "types": ["T043"], "canonical_name": "male-specific antibacterial humoral response", "definition": "An immune response against bacteria, specific to males and mediated through a body fluid. [GOC:go_curators]"}
{"concept_id": "C1155238", "aliases": [], "types": ["T043"], "canonical_name": "antifungal humoral response", "definition": "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1155241", "aliases": ["upregulation of antifungal peptide biosynthetic process", "antifungal peptide induction", "up regulation of antifungal peptide biosynthetic process", "antifungal polypeptide induction", "up-regulation of antifungal peptide biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of antifungal peptide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis. [GOC:mah]"}
{"concept_id": "C1155242", "aliases": ["response to parasitic fungus"], "types": ["T040"], "canonical_name": "response to parasitic fungi"}
{"concept_id": "C1155247", "aliases": ["down-regulation of antimicrobial humoral response", "attenuation of antimicrobial humoral response", "down regulation of antimicrobial humoral response", "downregulation of antimicrobial humoral response"], "types": ["T046"], "canonical_name": "negative regulation of antimicrobial humoral response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response. [GOC:go_curators]"}
{"concept_id": "C1155248", "aliases": ["hemolymph clotting"], "types": ["T042"], "canonical_name": "hemolymph coagulation", "definition": "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response. [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]"}
{"concept_id": "C1155250", "aliases": ["antibody-mediated immune response"], "types": ["T040"], "canonical_name": "immunoglobulin mediated immune response", "definition": "An immune response mediated by immunoglobulins, whether cell-bound or in solution. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1155251", "aliases": ["B-cell mediated immunity", "B-lymphocyte mediated immunity", "B-lymphocyte mediated immune effector process", "B lymphocyte mediated immune effector process", "B-cell mediated immune effector process", "B lymphocyte mediated immunity"], "types": ["T043"], "canonical_name": "B cell mediated immunity", "definition": "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1155252", "aliases": ["regulation of complement cascade, alternative pathway"], "types": ["T043"], "canonical_name": "regulation of complement activation, alternative pathway", "definition": "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation. [GOC:go_curators]"}
{"concept_id": "C1155253", "aliases": ["down-regulation of complement activation, alternative pathway", "down regulation of complement activation, alternative pathway", "negative regulation of complement cascade, alternative pathway", "downregulation of complement activation, alternative pathway"], "types": ["T043"], "canonical_name": "negative regulation of complement activation, alternative pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway. [GOC:go_curators]"}
{"concept_id": "C1155254", "aliases": ["upregulation of complement activation, alternative pathway", "up regulation of complement activation, alternative pathway", "up-regulation of complement activation, alternative pathway", "positive regulation of complement cascade, alternative pathway"], "types": ["T043"], "canonical_name": "positive regulation of complement activation, alternative pathway", "definition": "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway. [GOC:go_curators]"}
{"concept_id": "C1155255", "aliases": ["complement cascade, classical pathway"], "types": ["T044"], "canonical_name": "complement activation, classical pathway", "definition": "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1155256", "aliases": ["regulation of complement cascade, classical pathway"], "types": ["T043"], "canonical_name": "regulation of complement activation, classical pathway", "definition": "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation. [GOC:go_curators]"}
{"concept_id": "C1155257", "aliases": ["negative regulation of complement cascade, classical pathway", "down regulation of complement activation, classical pathway", "downregulation of complement activation, classical pathway", "down-regulation of complement activation, classical pathway"], "types": ["T043"], "canonical_name": "negative regulation of complement activation, classical pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway. [GOC:go_curators]"}
{"concept_id": "C1155258", "aliases": ["upregulation of complement activation, classical pathway", "positive regulation of complement cascade, classical pathway", "up-regulation of complement activation, classical pathway", "up regulation of complement activation, classical pathway"], "types": ["T043"], "canonical_name": "positive regulation of complement activation, classical pathway", "definition": "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway. [GOC:go_curators]"}
{"concept_id": "C1155260", "aliases": ["regulation of complement cascade"], "types": ["T043"], "canonical_name": "regulation of complement activation", "definition": "Any process that modulates the frequency, rate or extent of complement activation. [GOC:go_curators]"}
{"concept_id": "C1155262", "aliases": ["positive regulation of complement cascade", "up-regulation of complement activation", "up regulation of complement activation", "upregulation of complement activation"], "types": ["T043"], "canonical_name": "positive regulation of complement activation", "definition": "Any process that activates or increases the frequency, rate or extent of complement activation. [GOC:go_curators]"}
{"concept_id": "C1155263", "aliases": ["Th2 immune response"], "types": ["T043"], "canonical_name": "T-helper 2 type immune response"}
{"concept_id": "C1155264", "aliases": [], "types": ["T039"], "definition": "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling. [PMID:10234273]", "canonical_name": "induced systemic resistance"}
{"concept_id": "C1155266", "aliases": [], "types": ["T046"], "definition": "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]", "canonical_name": "inflammatory response"}
{"concept_id": "C1155267", "aliases": ["leucocyte cellular extravasation", "transendothelial leukocyte migration", "immune cell cellular extravasation", "leukocyte cellular extravasation"], "types": ["T043"], "canonical_name": "cellular extravasation", "definition": "The migration of a leukocyte from the blood vessels into the surrounding tissue. [GOC:jl]"}
{"concept_id": "C1155268", "aliases": [], "types": ["T040"], "canonical_name": "regulation of innate immune response", "definition": "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc]"}
{"concept_id": "C1155269", "aliases": ["down regulation of innate immune response", "downregulation of innate immune response", "down-regulation of innate immune response"], "types": ["T040"], "canonical_name": "negative regulation of innate immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. [GOC:go_curators]"}
{"concept_id": "C1155270", "aliases": ["up-regulation of innate immune response", "up regulation of innate immune response", "upregulation of innate immune response"], "types": ["T040"], "canonical_name": "positive regulation of innate immune response", "definition": "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc]"}
{"concept_id": "C1155274", "aliases": ["jasmonic acid/ethylene-dependent systemic resistance", "jasmonic acid and ethene-dependent systemic resistance"], "types": ["T043"], "canonical_name": "jasmonic acid and ethylene-dependent systemic resistance", "definition": "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen. [GOC:jy, PMID:10234273]"}
{"concept_id": "C1155275", "aliases": ["ethene biosynthetic process", "ethylene biosynthetic process from L-methionine", "ethylene formation", "ethene biosynthetic process from L-methionine", "ethylene biosynthesis from L-methionine", "ethylene biosynthesis", "ethene biosynthesis from L-methionine", "ethylene anabolism", "ethene biosynthesis", "ethylene synthesis"], "types": ["T044"], "canonical_name": "ethylene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. [ISBN:0387969845]"}
{"concept_id": "C1155276", "aliases": ["1-aminocyclopropane-1-carboxylate biosynthesis", "1-aminocyclopropane-1-carboxylate anabolism", "1-aminocyclopropane-1-carboxylate synthesis", "1-aminocyclopropane-1-carboxylate formation"], "types": ["T044"], "canonical_name": "1-aminocyclopropane-1-carboxylate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. [GOC:go_curators]"}
{"concept_id": "C1155279", "aliases": ["jasmonic acid formation", "jasmonic acid anabolism", "jasmonic acid synthesis", "jasmonic acid biosynthesis"], "types": ["T044"], "canonical_name": "jasmonic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative. [ISBN:0387969845]"}
{"concept_id": "C1155281", "aliases": ["salicylic acid-dependent systemic resistance"], "types": ["T040"], "canonical_name": "systemic acquired resistance", "definition": "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance. [GOC:lr, ISBN:0521436125]"}
{"concept_id": "C1155282", "aliases": ["induction of phytoalexin anabolism", "induction of phytoalexin synthesis", "induction of phytoalexin formation", "induction of phytoalexin biosynthesis"], "types": ["T044"], "canonical_name": "induction of phytoalexin biosynthetic process", "definition": "The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection. [ISBN:0943088399]"}
{"concept_id": "C1155283", "aliases": ["indole phytoalexin biosynthesis", "indole phytoalexin synthesis", "indole phytoalexin formation", "indole phytoalexin anabolism"], "types": ["T044"], "canonical_name": "indole phytoalexin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response. [GOC:sm, ISBN:0198547684]"}
{"concept_id": "C1155284", "aliases": ["isoflavonoid phytoalexin synthesis", "isoflavonoid phytoalexin anabolism", "isoflavonoid phytoalexin biosynthesis", "isoflavonoid phytoalexin formation"], "types": ["T044"], "canonical_name": "isoflavonoid phytoalexin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. [GOC:ai]"}
{"concept_id": "C1155285", "aliases": ["virus-induced PTGS", "RNAi-mediated antiviral immunity", "VIGS", "virus induced gene silencing", "RNAi-mediated antiviral immune response"], "types": ["T040"], "definition": "A post-transcriptional gene silencing pathway mediated by the action of regulatory RNAs that protects against foreign organism invasion by restricting viral replication and dissemination. [GOC:jl, PMID:17693253, PMID:21724934, PMID:23686236, PMID:24732439, PMID:31100912]", "canonical_name": "virus-induced gene silencing"}
{"concept_id": "C1155286", "aliases": ["response to bacteria"], "types": ["T040"], "canonical_name": "response to bacterium", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb]"}
{"concept_id": "C1155290", "aliases": ["response to symbiotic bacteria"], "types": ["T038"], "canonical_name": "response to symbiotic bacterium", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism. [GOC:hb, ISBN:0198506732]"}
{"concept_id": "C1155291", "aliases": ["cellular DNA damage response", "response to genotoxic stress", "DNA damage response", "response to DNA damage stimulus"], "types": ["T043"], "canonical_name": "cellular response to DNA damage stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]"}
{"concept_id": "C1155292", "aliases": [], "types": ["T043"], "canonical_name": "DNA damage response, signal transduction resulting in cell cycle arrest"}
{"concept_id": "C1155293", "aliases": [], "types": ["T044"], "canonical_name": "DNA damage induced protein phosphorylation", "definition": "The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage. [GOC:go_curators]"}
{"concept_id": "C1155294", "aliases": [], "types": ["T043"], "canonical_name": "DNA damage response, signal transduction resulting in induction of apoptosis"}
{"concept_id": "C1155295", "aliases": [], "types": ["T044"], "canonical_name": "p53-mediated DNA damage response"}
{"concept_id": "C1155299", "aliases": [], "types": ["T045"], "definition": "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]", "canonical_name": "telomere maintenance"}
{"concept_id": "C1155300", "aliases": ["telomerase-dependent telomere maintenance"], "types": ["T045"], "canonical_name": "telomere maintenance via telomerase", "definition": "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. [GOC:elh]"}
{"concept_id": "C1155301", "aliases": [], "types": ["T043"], "canonical_name": "telomerase-independent telomere maintenance"}
{"concept_id": "C1155302", "aliases": ["telomere end protection"], "types": ["T045"], "definition": "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]", "canonical_name": "telomere capping"}
{"concept_id": "C1155303", "aliases": ["endoplasmic reticulum overload response", "ER overload response", "ER-overload response"], "types": ["T044"], "definition": "The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB. [PMID:10390516]", "canonical_name": "EOR"}
{"concept_id": "C1155304", "aliases": ["ER to nucleus signalling pathway", "ER-nuclear signaling pathway", "endoplasmic reticulum to nucleus signaling pathway", "endoplasmic reticulum-nuclear signaling pathway", "ER to nucleus signaling pathway", "ER-nuclear signalling pathway"], "types": ["T044"], "canonical_name": "ER-nucleus signaling pathway", "definition": "The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. [GOC:mah]"}
{"concept_id": "C1155305", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of NF-kappaB transcription factor activity by ER overload response"}
{"concept_id": "C1155306", "aliases": ["response to fungi"], "types": ["T040"], "canonical_name": "response to fungus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. [GOC:hb]"}
{"concept_id": "C1155309", "aliases": ["response to symbiotic fungi"], "types": ["T038"], "canonical_name": "response to symbiotic fungus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism. [GOC:hb, ISBN:0198506732]"}
{"concept_id": "C1155310", "aliases": ["mechanical stimulus response"], "types": ["T040"], "canonical_name": "response to mechanical stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:hb]"}
{"concept_id": "C1155311", "aliases": [], "types": ["T040"], "canonical_name": "thigmotropism", "definition": "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it. [GOC:jl, PMID:16153165]"}
{"concept_id": "C1155312", "aliases": [], "types": ["T043"], "canonical_name": "response to oxidative stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]"}
{"concept_id": "C1155315", "aliases": ["response to LHPO"], "types": ["T043"], "canonical_name": "response to lipid hydroperoxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids. [GOC:jl, PMID:10944149]"}
{"concept_id": "C1155316", "aliases": ["response to ROI", "response to active oxygen species", "response to AOS", "response to reactive oxygen intermediate", "response to reactive oxidative species", "response to ROS"], "types": ["T043"], "canonical_name": "response to reactive oxygen species", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:krc]"}
{"concept_id": "C1155317", "aliases": [], "types": ["T043"], "canonical_name": "response to hydrogen peroxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [GOC:jl]"}
{"concept_id": "C1155319", "aliases": [], "types": ["T043"], "canonical_name": "response to oxygen radical", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. [GOC:krc, ISBN:0124325653]"}
{"concept_id": "C1155320", "aliases": [], "types": ["T043"], "canonical_name": "response to superoxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. [GOC:krc, ISBN:0198506732]"}
{"concept_id": "C1155321", "aliases": [], "types": ["T043"], "canonical_name": "response to singlet oxygen", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst. [GOC:krc, ISBN:0124325653, ISBN:0198506732]"}
{"concept_id": "C1155323", "aliases": ["response to insects"], "types": ["T040"], "canonical_name": "response to insect", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect. [GOC:hb]"}
{"concept_id": "C1155324", "aliases": ["response to nematodes"], "types": ["T040"], "canonical_name": "response to nematode", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. [GOC:hb]"}
{"concept_id": "C1155327", "aliases": ["response to protozoon", "response to protozoa"], "types": ["T043"], "canonical_name": "response to protozoan", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. [GOC:ai]"}
{"concept_id": "C1155328", "aliases": ["defence response to virus", "defense response to virus", "antiviral response", "response to viruses", "defense response to viruses"], "types": ["T040"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:hb]", "canonical_name": "response to virus"}
{"concept_id": "C1155329", "aliases": [], "types": ["T043"], "canonical_name": "phage shock", "definition": "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage. [GOC:add, GOC:jl, PMID:15485810, PMID:16045608]"}
{"concept_id": "C1155330", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. [GOC:jl]"}
{"concept_id": "C1155331", "aliases": [], "types": ["T040"], "canonical_name": "fruiting body development in cellular response to starvation"}
{"concept_id": "C1155332", "aliases": ["sorocarp biosynthesis", "sorocarp formation"], "types": ["T040"], "canonical_name": "sorocarp development", "definition": "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum. [GOC:mah, GOC:mtg_sensu, ISBN:0521583640, PMID:4332228]"}
{"concept_id": "C1155333", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to glucose starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. [GOC:jl]"}
{"concept_id": "C1155334", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nitrogen starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. [GOC:jl]"}
{"concept_id": "C1155335", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to phosphate starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. [GOC:jl]"}
{"concept_id": "C1155336", "aliases": [], "types": ["T043"], "canonical_name": "stringent response", "definition": "A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation. [GOC:jl, ISBN:0124325653, PMID:11282471]"}
{"concept_id": "C1155337", "aliases": ["sterol depletion response"], "types": ["T044"], "canonical_name": "response to sterol depletion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:bf, ISBN:0198506732]"}
{"concept_id": "C1155341", "aliases": [], "types": ["T040"], "canonical_name": "response to symbiont", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:hb, ISBN:0198506732]"}
{"concept_id": "C1155342", "aliases": [], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. [GOC:mah]", "canonical_name": "cellular response to unfolded protein"}
{"concept_id": "C1155346", "aliases": ["unfolded protein response, activation of target gene transcription"], "types": ["T045"], "canonical_name": "unfolded protein response, target gene transcriptional activation"}
{"concept_id": "C1155347", "aliases": ["physiological response to wounding"], "types": ["T040"], "canonical_name": "response to wounding", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. [GOC:go_curators]"}
{"concept_id": "C1155349", "aliases": ["taxis in response to atmospheric oxygen"], "types": ["T043"], "canonical_name": "aerotaxis", "definition": "The directed movement of a motile cell or organism in response to environmental oxygen. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1155350", "aliases": ["taxis in response to oxidizable substrate"], "types": ["T043"], "canonical_name": "chemotaxis to oxidizable substrate", "definition": "The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose. [GOC:jl, PMID:11029423]"}
{"concept_id": "C1155352", "aliases": ["taxis in response to redox potential", "taxis in response to redox stimulus", "redoxtaxis"], "types": ["T043"], "canonical_name": "redox taxis", "definition": "The directed movement of a motile cell or organism in response to redox potential. [GOC:jl, PMID:11029423]"}
{"concept_id": "C1155353", "aliases": ["energytaxis", "taxis in response to energy source"], "types": ["T043"], "canonical_name": "energy taxis", "definition": "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. [GOC:jl, PMID:11029423]"}
{"concept_id": "C1155354", "aliases": ["phototactic behaviour", "phototactic behavior", "phototaxis"], "types": ["T038"], "definition": "The directed movement of a motile cell or organism in response to light. [GOC:jl, ISBN:0192800981]", "canonical_name": "taxis in response to light"}
{"concept_id": "C1155355", "aliases": ["taxis in response to electron acceptor"], "types": ["T043"], "canonical_name": "taxis to electron acceptor", "definition": "The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate. [GOC:jl, PMID:11029423]"}
{"concept_id": "C1155356", "aliases": ["geotaxis", "geotactic behavior", "gravitactic behavior", "taxis in response to gravitational stimulus", "gravitactic behaviour", "geotactic behaviour", "taxis in response to gravity"], "types": ["T043"], "canonical_name": "gravitaxis", "definition": "The directed movement of a motile cell or organism in response to gravity. [GOC:jid, GOC:jl]"}
{"concept_id": "C1155357", "aliases": ["cell surface receptor linked signalling pathway", "cell surface receptor linked signal transduction", "cell surface receptor linked signaling pathway"], "types": ["T044"], "canonical_name": "cell surface receptor signaling pathway", "definition": "The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]"}
{"concept_id": "C1155359", "aliases": ["cytokine and chemokine mediated signaling pathway", "cytokine mediated signalling pathway"], "types": ["T043"], "canonical_name": "cytokine-mediated signaling pathway", "definition": "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629]"}
{"concept_id": "C1155360", "aliases": ["enzyme linked receptor protein signaling pathway", "enzyme linked receptor protein signalling pathway"], "types": ["T044"], "canonical_name": "enzyme-linked receptor protein signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, ISBN:0815316194]"}
{"concept_id": "C1155361", "aliases": ["receptor guanylyl cyclase signalling pathway"], "types": ["T044"], "canonical_name": "receptor guanylyl cyclase signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:16815030]"}
{"concept_id": "C1155362", "aliases": ["transmembrane receptor protein serine/threonine kinase signalling pathway"], "types": ["T044"], "canonical_name": "transmembrane receptor protein serine/threonine kinase signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]"}
{"concept_id": "C1155363", "aliases": ["TGF-beta receptor signalling pathway", "transforming growth factor beta receptor signaling pathway", "transforming growth factor beta receptor signalling pathway", "TGFbeta receptor signaling pathway", "TGF-beta receptor signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah, GOC:signaling]", "canonical_name": "TGFbeta receptor signalling pathway"}
{"concept_id": "C1155364", "aliases": ["bone morphogenetic protein signalling pathway", "BMP signalling pathway", "BMP signaling pathway", "bone morphogenetic protein signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:0878932437, PMID:17428827]", "canonical_name": "BMP receptor signaling pathway"}
{"concept_id": "C1155365", "aliases": ["regulation of BMP signalling pathway", "regulation of bone morphogenetic protein signaling pathway", "regulation of BMP receptor signaling pathway", "regulation of bone morphogenetic protein signalling pathway"], "types": ["T043"], "canonical_name": "regulation of BMP signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C1155366", "aliases": ["down regulation of BMP signaling pathway", "negative regulation of BMP signalling pathway", "negative regulation of bone morphogenetic protein signalling pathway", "negative regulation of bone morphogenetic protein signaling pathway", "down-regulation of BMP signaling pathway", "downregulation of BMP signaling pathway", "negative regulation of BMP receptor signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of BMP signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155367", "aliases": ["positive regulation of BMP receptor signaling pathway", "positive regulation of BMP signalling pathway", "upregulation of BMP signaling pathway", "positive regulation of bone morphogenetic protein signalling pathway", "up-regulation of BMP signaling pathway", "positive regulation of bone morphogenetic protein signaling pathway", "up regulation of BMP signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of BMP signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. [GOC:go_curators]"}
{"concept_id": "C1155368", "aliases": ["co-SMAD protein phosphorylation", "common-mediator SMAD protein phosphorylation", "common partner SMAD protein phosphorylation", "common mediator SMAD protein phosphorylation"], "types": ["T040"], "canonical_name": "common-partner SMAD protein phosphorylation", "definition": "The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus. [GOC:dph, ISBN:3527303782]"}
{"concept_id": "C1155369", "aliases": ["regulation of TGFbeta receptor signaling pathway", "regulation of TGF-beta receptor signaling pathway", "regulation of transforming growth factor beta receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of transforming growth factor beta receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C1155370", "aliases": ["down-regulation of transforming growth factor beta receptor signaling pathway", "negative regulation of transforming growth factor beta receptor signalling pathway", "downregulation of transforming growth factor beta receptor signaling pathway", "negative regulation of TGFbeta receptor signaling pathway", "down regulation of transforming growth factor beta receptor signaling pathway", "negative regulation of TGF-beta receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of transforming growth factor beta receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C1155371", "aliases": ["up-regulation of transforming growth factor beta receptor signaling pathway", "upregulation of transforming growth factor beta receptor signaling pathway", "positive regulation of TGFbeta receptor signaling pathway", "up regulation of transforming growth factor beta receptor signaling pathway", "positive regulation of TGF-beta receptor signaling pathway", "positive regulation of transforming growth factor beta receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of transforming growth factor beta receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. [GOC:go_curators]"}
{"concept_id": "C1155373", "aliases": ["SMAD protein heteromerization"], "types": ["T044"], "canonical_name": "SMAD protein complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. [GOC:isa_complete]"}
{"concept_id": "C1155377", "aliases": ["TGF-beta receptor complex assembly", "TGF-beta:type II receptor:type I receptor complex assembly", "TGFbeta receptor complex assembly"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor complex assembly", "definition": "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex. [GOC:jl, Reactome:R-HSA-170840, Wikipedia:TGF_beta_signaling_pathway]"}
{"concept_id": "C1155378", "aliases": ["transmembrane receptor protein tyrosine kinase signalling pathway"], "types": ["T044"], "canonical_name": "transmembrane receptor protein tyrosine kinase signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]"}
{"concept_id": "C1155379", "aliases": ["ERBB1 signaling pathway", "EGF receptor signalling pathway", "epidermal growth factor receptor signalling pathway", "EGFR signaling pathway", "receptor tyrosine-protein kinase erbB-1 signaling pathway", "EGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "epidermal growth factor receptor signaling pathway", "definition": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]"}
{"concept_id": "C1155380", "aliases": ["epidermal growth factor ligand processing"], "types": ["T044"], "canonical_name": "EGF receptor ligand processing"}
{"concept_id": "C1155381", "aliases": ["signaling by Gurken", "gurken receptor signalling pathway", "gurken receptor signaling pathway"], "types": ["T044"], "canonical_name": "gurken signaling pathway", "definition": "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to a ligand Gurken. [GOC:bf, PMID:23972992]"}
{"concept_id": "C1155382", "aliases": ["regulation of EGF receptor activity", "regulation of EGFR activity", "regulation of epidermal growth factor receptor activity"], "types": ["T044"], "canonical_name": "regulation of epidermal growth factor-activated receptor activity", "definition": "Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. [GOC:dph, GOC:go_curators]"}
{"concept_id": "C1155383", "aliases": ["negative regulation of epidermal growth factor receptor activity", "down regulation of epidermal growth factor receptor activity", "negative regulation of EGFR activity", "downregulation of epidermal growth factor receptor activity", "negative regulation of EGF receptor activity", "EGF receptor downregulation", "down-regulation of epidermal growth factor receptor activity"], "types": ["T044"], "canonical_name": "negative regulation of epidermal growth factor-activated receptor activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity. [GOC:go_curators]"}
{"concept_id": "C1155385", "aliases": ["regulation of EGFR signaling pathway", "regulation of EGF receptor signalling pathway", "regulation of EGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of epidermal growth factor receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators]"}
{"concept_id": "C1155386", "aliases": ["down regulation of epidermal growth factor receptor signaling pathway", "negative regulation of EGFR signaling pathway", "downregulation of epidermal growth factor receptor signaling pathway", "down-regulation of epidermal growth factor receptor signaling pathway", "negative regulation of EGF receptor signalling pathway", "negative regulation of EGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of epidermal growth factor receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators]"}
{"concept_id": "C1155387", "aliases": ["up-regulation of epidermal growth factor receptor signaling pathway", "up regulation of epidermal growth factor receptor signaling pathway", "positive regulation of EGFR signaling pathway", "upregulation of epidermal growth factor receptor signaling pathway", "positive regulation of EGF receptor signalling pathway", "positive regulation of EGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of epidermal growth factor receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators]"}
{"concept_id": "C1155388", "aliases": ["Eph receptor signalling pathway", "Eph receptor signaling pathway"], "types": ["T044"], "canonical_name": "ephrin receptor signaling pathway", "definition": "The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]"}
{"concept_id": "C1155389", "aliases": ["FGFR signaling pathway", "FGF receptor signalling pathway", "fibroblast growth factor receptor signalling pathway", "FGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. [GOC:ceb]"}
{"concept_id": "C1155390", "aliases": ["regulation of FGF receptor signalling pathway", "regulation of FGFR signaling pathway", "regulation of FGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of fibroblast growth factor receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. [GOC:go_curators]"}
{"concept_id": "C1155391", "aliases": ["down-regulation of fibroblast growth factor receptor signaling pathway", "downregulation of fibroblast growth factor receptor signaling pathway", "negative regulation of FGFR signaling pathway", "negative regulation of FGF receptor signalling pathway", "down regulation of fibroblast growth factor receptor signaling pathway", "negative regulation of FGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of fibroblast growth factor receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. [GOC:go_curators]"}
{"concept_id": "C1155392", "aliases": ["up regulation of fibroblast growth factor receptor signaling pathway", "positive regulation of FGF receptor signaling pathway", "upregulation of fibroblast growth factor receptor signaling pathway", "positive regulation of FGFR signaling pathway", "up-regulation of fibroblast growth factor receptor signaling pathway", "positive regulation of FGF receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of fibroblast growth factor receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. [GOC:go_curators]"}
{"concept_id": "C1155393", "aliases": ["HGF receptor signalling pathway", "hepatocyte growth factor receptor signaling pathway", "HGF receptor signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by a ligand binding to a hepatocyte growth factor receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]", "canonical_name": "Met signaling pathway"}
{"concept_id": "C1155394", "aliases": ["IGF receptor signaling pathway", "IGF receptor signalling pathway"], "types": ["T044"], "canonical_name": "insulin-like growth factor receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]"}
{"concept_id": "C1155395", "aliases": ["insulin receptor signalling pathway"], "types": ["T044"], "canonical_name": "insulin receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. [GOC:ceb]"}
{"concept_id": "C1155396", "aliases": ["regulation of insulin receptor signalling pathway"], "types": ["T043"], "canonical_name": "regulation of insulin receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of insulin receptor signaling. [GOC:bf]"}
{"concept_id": "C1155397", "aliases": ["negative regulation of insulin receptor signalling pathway", "down-regulation of insulin receptor signaling pathway", "downregulation of insulin receptor signaling pathway", "down regulation of insulin receptor signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of insulin receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. [GOC:bf]"}
{"concept_id": "C1155398", "aliases": ["upregulation of insulin receptor signaling pathway", "positive regulation of insulin receptor signalling pathway", "up regulation of insulin receptor signaling pathway", "up-regulation of insulin receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of insulin receptor signaling pathway", "definition": "Any process that increases the frequency, rate or extent of insulin receptor signaling. [GOC:bf]"}
{"concept_id": "C1155400", "aliases": ["PDGFR signaling pathway", "PDGF receptor signaling pathway", "PDGF receptor signalling pathway"], "types": ["T044"], "canonical_name": "platelet-derived growth factor receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]"}
{"concept_id": "C1155401", "aliases": ["sev receptor signaling pathway", "sevenless signalling pathway", "sev signaling pathway"], "types": ["T044"], "canonical_name": "sevenless signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:signaling, PMID:10771085]"}
{"concept_id": "C1155402", "aliases": ["regulation of sevenless signalling pathway", "regulation of sev signaling pathway"], "types": ["T044"], "canonical_name": "regulation of sevenless signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the sevenless signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155403", "aliases": ["negative regulation of sevenless signalling pathway", "down regulation of sevenless signaling pathway", "down-regulation of sevenless signaling pathway", "downregulation of sevenless signaling pathway", "negative regulation of sev signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of sevenless signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155404", "aliases": ["up-regulation of sevenless signaling pathway", "up regulation of sevenless signaling pathway", "upregulation of sevenless signaling pathway", "positive regulation of sev signaling pathway", "positive regulation of sevenless signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of sevenless signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155405", "aliases": ["signal complex formation"], "types": ["T044"], "canonical_name": "signal complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. [GOC:bf, GOC:signaling, PMID:9646862]"}
{"concept_id": "C1155406", "aliases": ["angiopoietin-Tie signaling pathway", "Tie receptor signaling pathway", "Tie receptor signalling pathway", "angiopoietin/Tie signaling pathway", "Tek receptor signaling"], "types": ["T044"], "canonical_name": "Tie signaling pathway", "definition": "The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling, PMID:11283723, PMID:11566266]"}
{"concept_id": "C1155407", "aliases": ["torso signalling pathway"], "types": ["T044"], "canonical_name": "torso signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:go_curators, PMID:8343949]"}
{"concept_id": "C1155409", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor protein tyrosine kinase ligand binding", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1155410", "aliases": ["VEGF receptor signalling pathway", "VEGFR signaling pathway", "VEGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "vascular endothelial growth factor receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]"}
{"concept_id": "C1155411", "aliases": ["transmembrane receptor protein tyrosine phosphatase signalling pathway"], "types": ["T044"], "canonical_name": "transmembrane receptor protein tyrosine phosphatase signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]"}
{"concept_id": "C1155413", "aliases": ["acetylcholine receptor signalling, muscarinic pathway", "muscarinic acetylcholine receptor signaling pathway", "G-protein coupled acetylcholine receptor signaling pathway"], "types": ["T044"], "canonical_name": "G protein-coupled acetylcholine receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1155414", "aliases": ["dopamine receptor signalling pathway"], "types": ["T044"], "canonical_name": "dopamine receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. [GOC:mah, PMID:21711983]"}
{"concept_id": "C1155415", "aliases": ["G-protein signaling, coupled to cyclic nucleotide second messenger", "G protein signaling, coupled to cyclic nucleotide second messenger", "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "GPCR signaling pathway via cyclic nucleotide second messenger", "G protein signalling, coupled to cyclic nucleotide second messenger", "G-protein signalling, coupled to cyclic nucleotide second messenger"], "types": ["T044"], "canonical_name": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "definition": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]"}
{"concept_id": "C1155416", "aliases": ["adenylate cyclase-modulating GPCR signaling pathway", "G-protein signalling, coupled to cAMP nucleotide second messenger", "GPCR signaling pathway via modulation of adenylate cyclase activity", "G protein signaling, coupled to cyclic AMP nucleotide second messenger", "G protein signalling, coupled to cyclic AMP nucleotide second messenger", "GPCR signaling pathway via cAMP second messenger", "G protein signaling, coupled to cAMP nucleotide second messenger", "G-protein signalling, coupled to cyclic AMP nucleotide second messenger", "G protein signalling, coupled to cAMP nucleotide second messenger", "G-protein signaling, coupled to cyclic AMP nucleotide second messenger", "G-protein signaling, coupled to cAMP nucleotide second messenger"], "types": ["T044"], "canonical_name": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). [GOC:mah, GOC:signaling, ISBN:0815316194]"}
{"concept_id": "C1155417", "aliases": ["G-protein signalling, adenylyl cyclase activating pathway", "positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway", "G-protein signalling, adenylate cyclase activating pathway", "G-protein signaling, adenylyl cyclase activating pathway", "GPCR signaling pathway via activation of adenylate cyclase activity", "G protein signaling, adenylyl cyclase activating pathway", "adenylate cyclase-activating GPCR signaling pathway", "G protein signaling, adenylate cyclase activating pathway", "GPCR signaling pathway via activation of adenylate cyclase", "G protein signalling, adenylate cyclase activating pathway", "G-protein signaling, adenylate cyclase activating pathway", "G protein signalling, adenylyl cyclase activating pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]"}
{"concept_id": "C1155418", "aliases": ["adenylate cyclase activation", "adenylyl cyclase activation"], "types": ["T044"], "canonical_name": "activation of adenylate cyclase activity", "definition": "Any process that initiates the activity of the inactive enzyme adenylate cyclase. [GOC:ai]"}
{"concept_id": "C1155419", "aliases": ["dopamine receptor, adenylate cyclase activating pathway", "dopamine receptor, adenylyl cyclase activating pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-activating dopamine receptor signaling pathway", "definition": "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling]"}
{"concept_id": "C1155420", "aliases": ["serotonin receptor, adenylate cyclase activating pathway", "serotonin receptor, adenylyl cyclase activating pathway", "activation of adenylate cyclase activity by serotonin receptor signalling pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-activating serotonin receptor signaling pathway", "definition": "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C1155421", "aliases": ["G-protein signalling, adenylyl cyclase inhibiting pathway", "inhibition of adenylate cyclase activity by G-protein signaling pathway", "GPCR signaling pathway via inhibition of adenylate cyclase activity", "G-protein signaling, adenylyl cyclase inhibiting pathway", "G protein signaling, adenylate cyclase inhibiting pathway", "G protein signaling, adenylyl cyclase inhibiting pathway", "G-protein signaling, adenylate cyclase inhibiting pathway", "G-protein signalling, adenylate cyclase inhibiting pathway", "G protein signalling, adenylyl cyclase inhibiting pathway", "G protein signalling, adenylate cyclase inhibiting pathway", "adenylate cyclase-inhibiting GPCR signaling pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]"}
{"concept_id": "C1155422", "aliases": ["inhibition of adenylate cyclase activity by dopamine receptor signalling pathway", "inhibition of adenylate cyclase activity by dopamine receptor signaling pathway", "dopamine receptor, adenylate cyclase inhibiting pathway", "dopamine receptor, adenylyl cyclase inhibiting pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-inhibiting dopamine receptor signaling pathway", "definition": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C1155423", "aliases": ["adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway", "inhibition of adenylate cyclase activity by G-protein-coupled glutamate receptor signaling pathway", "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway", "metabotropic glutamate receptor, adenylate cyclase inhibiting pathway", "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway", "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway", "definition": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C1155424", "aliases": ["muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway", "muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway", "definition": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C1155425", "aliases": ["regulation of adenylyl cyclase activity"], "types": ["T044"], "canonical_name": "regulation of adenylate cyclase activity", "definition": "Any process that modulates the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators]"}
{"concept_id": "C1155426", "aliases": ["downregulation of adenylate cyclase activity", "down-regulation of adenylate cyclase activity", "down regulation of adenylate cyclase activity", "negative regulation of adenylyl cyclase activity"], "types": ["T043"], "canonical_name": "negative regulation of adenylate cyclase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators]"}
{"concept_id": "C1155427", "aliases": ["positive regulation of adenylyl cyclase activity", "upregulation of adenylate cyclase activity", "up regulation of adenylate cyclase activity", "up-regulation of adenylate cyclase activity"], "types": ["T044"], "canonical_name": "positive regulation of adenylate cyclase activity", "definition": "Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators]"}
{"concept_id": "C1155428", "aliases": ["inhibition of adenylate cyclase activity by serotonin receptor signalling pathway", "inhibition of adenylate cyclase activity by serotonin receptor signaling pathway", "serotonin receptor, adenylyl cyclase inhibiting pathway", "serotonin receptor, adenylate cyclase inhibiting pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-inhibiting serotonin receptor signaling pathway", "definition": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C1155429", "aliases": ["guanylate cyclase-activating G-protein coupled receptor signaling pathway", "GPCR signaling pathway via activation of guanylate cyclase activity", "G protein signaling, coupled to cGMP nucleotide second messenger", "G-protein signalling, coupled to cGMP nucleotide second messenger", "GPCR signaling pathway via cGMP second messenger", "G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger", "G-protein signaling, coupled to cGMP nucleotide second messenger", "G protein signalling, coupled to cGMP nucleotide second messenger"], "types": ["T044"], "canonical_name": "G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger", "definition": "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP). [GOC:mah, GOC:signaling, ISBN:0815316194]"}
{"concept_id": "C1155430", "aliases": ["PLC-activating GPCR signaling pathway", "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger", "phospholipase C-activating G-protein coupled receptor signaling pathway", "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "G-protein coupled receptor signaling pathway coupled to IP3 second messenger"], "types": ["T044"], "canonical_name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]"}
{"concept_id": "C1155431", "aliases": ["cytosolic calcium ion concentration elevation", "cytoplasmic calcium ion concentration elevation", "elevation of calcium ion concentration in cytosol", "elevation of cytoplasmic calcium ion concentration", "elevation of calcium ion concentration in cytoplasm", "elevation of cytosolic calcium ion concentration"], "types": ["T044"], "canonical_name": "positive regulation of cytosolic calcium ion concentration", "definition": "Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]"}
{"concept_id": "C1155433", "aliases": ["activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway", "metabotropic glutamate receptor, phospholipase C activating pathway", "activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway"], "types": ["T044"], "canonical_name": "activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway"}
{"concept_id": "C1155434", "aliases": ["muscarinic receptor signaling pathway via activation of PLC", "activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway", "activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway", "muscarinic acetylcholine receptor, phospholipase C activating pathway", "activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway", "phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway"], "types": ["T044"], "canonical_name": "phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway", "definition": "A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C1155435", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-4,5-bisphosphate hydrolysis", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1155436", "aliases": ["phospholipase C activation"], "types": ["T044"], "canonical_name": "activation of phospholipase C activity", "definition": "The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand. [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]"}
{"concept_id": "C1155437", "aliases": ["activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway"], "types": ["T044"], "canonical_name": "activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway"}
{"concept_id": "C1155438", "aliases": ["serotonin receptor, phospholipase C activating pathway", "activation of phospholipase C activity by serotonin receptor signalling pathway"], "types": ["T044"], "canonical_name": "activation of phospholipase C activity by serotonin receptor signaling pathway"}
{"concept_id": "C1155439", "aliases": ["activation of phospholipase C activity by tachykinin receptor signalling pathway", "tachykinin receptor, phospholipase C activating pathway"], "types": ["T044"], "canonical_name": "activation of phospholipase C activity by tachykinin receptor signaling pathway"}
{"concept_id": "C1155440", "aliases": ["4-aminobutanoate signaling pathway", "4-aminobutyrate signaling pathway", "gamma-aminobutyric acid signalling pathway", "4-aminobutyrate signalling pathway", "GABA signalling pathway", "GABA signaling pathway", "4-aminobutanoate signalling pathway"], "types": ["T044"], "canonical_name": "gamma-aminobutyric acid signaling pathway", "definition": "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell. [GOC:mah]"}
{"concept_id": "C1155441", "aliases": ["glutamate signaling pathway", "glutamate signalling pathway"], "types": ["T044"], "canonical_name": "glutamate receptor signaling pathway", "definition": "The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:9131252]"}
{"concept_id": "C1155442", "aliases": ["G-protein coupled glutamate receptor signaling pathway", "metabotropic glutamate receptor signaling pathway", "metabotropic glutamate receptor signalling pathway"], "types": ["T044"], "canonical_name": "G protein-coupled glutamate receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling, PMID:9131252]"}
{"concept_id": "C1155443", "aliases": ["neuropeptide signalling pathway"], "types": ["T044"], "canonical_name": "neuropeptide signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1155444", "aliases": ["octopamine/tyramine signaling pathway", "octopamine or tyramine signalling pathway"], "types": ["T044"], "canonical_name": "octopamine or tyramine signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by octopamine or tyramine binding to their receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription, and ending with the regulation of a downstream cellular process. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters. [GOC:mah, PMID:15355245]"}
{"concept_id": "C1155445", "aliases": ["regulation of G-protein-coupled receptor protein signalling pathway", "regulation of G protein coupled receptor protein signaling pathway", "regulation of GPCR protein signalling pathway", "regulation of G-protein coupled receptor protein signaling pathway", "regulation of G-protein coupled receptor protein signalling pathway", "regulation of GPCR protein signaling pathway", "regulation of G protein coupled receptor protein signalling pathway"], "types": ["T043"], "canonical_name": "regulation of G protein-coupled receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155446", "aliases": ["negative regulation of G protein coupled receptor protein signaling pathway", "downregulation of G-protein coupled receptor protein signaling pathway", "negative regulation of GPCR protein signaling pathway", "negative regulation of GPCR protein signalling pathway", "negative regulation of G-protein coupled receptor protein signaling pathway", "down regulation of G-protein coupled receptor protein signaling pathway", "negative regulation of G-protein-coupled receptor protein signalling pathway", "negative regulation of G-protein coupled receptor protein signalling pathway", "negative regulation of G protein coupled receptor protein signalling pathway", "down-regulation of G-protein coupled receptor protein signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of G protein-coupled receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155447", "aliases": ["positive regulation of GPCR protein signaling pathway", "up-regulation of G-protein coupled receptor protein signaling pathway", "upregulation of G-protein coupled receptor protein signaling pathway", "positive regulation of G-protein-coupled receptor protein signaling pathway", "positive regulation of G-protein-coupled receptor protein signalling pathway", "positive regulation of G-protein coupled receptor protein signaling pathway", "positive regulation of GPCR protein signalling pathway", "positive regulation of G-protein coupled receptor protein signalling pathway", "up regulation of G-protein coupled receptor protein signaling pathway", "positive regulation of G protein coupled receptor protein signalling pathway", "positive regulation of G protein coupled receptor protein signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of G protein-coupled receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity. [GOC:go_curators]"}
{"concept_id": "C1155448", "aliases": ["PKC deactivation"], "types": ["T044"], "canonical_name": "protein kinase C deactivation", "definition": "Any process resulting in the inhibition or termination of the activity of protein kinase C. [GOC:bf]"}
{"concept_id": "C1155449", "aliases": ["serotonin receptor signalling pathway"], "types": ["T044"], "canonical_name": "serotonin receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. [GOC:mah]"}
{"concept_id": "C1155450", "aliases": ["tachykinin signalling pathway"], "types": ["T044"], "canonical_name": "tachykinin receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Tachykinin is a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2). [GOC:mah, PMID:14723970]"}
{"concept_id": "C1155451", "aliases": ["integrin-mediated signalling pathway"], "types": ["T044"], "canonical_name": "integrin-mediated signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]"}
{"concept_id": "C1155452", "aliases": ["Notch signalling pathway", "N signaling pathway", "N signalling pathway", "Notch-receptor signalling pathway", "Notch receptor signaling pathway", "Notch signaling pathway", "Notch receptor signalling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:go_curators, GOC:signaling]", "canonical_name": "Notch-receptor signaling pathway"}
{"concept_id": "C1155453", "aliases": ["N receptor processing"], "types": ["T044"], "canonical_name": "Notch receptor processing", "definition": "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. [PMID:12651094, PMID:14986688]"}
{"concept_id": "C1155454", "aliases": ["Notch receptor target transcription factor activation"], "types": ["T044"], "canonical_name": "N receptor target transcription factor activation"}
{"concept_id": "C1155455", "aliases": ["regulation of Notch signalling pathway", "regulation of N signaling pathway", "regulation of N signalling pathway"], "types": ["T044"], "canonical_name": "regulation of Notch signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155456", "aliases": ["down regulation of Notch signaling pathway", "negative regulation of N signaling pathway", "negative regulation of N signalling pathway", "down-regulation of Notch signaling pathway", "negative regulation of Notch signalling pathway", "downregulation of Notch signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of Notch signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155457", "aliases": ["positive regulation of N signaling pathway", "positive regulation of Notch signalling pathway", "positive regulation of N signalling pathway", "up regulation of Notch signaling pathway", "up-regulation of Notch signaling pathway", "upregulation of Notch signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of Notch signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155458", "aliases": ["osmolarity sensing", "osmosensory signalling pathway", "osmosensory signal transduction", "osmolarity sensing signaling pathway", "signal transduction during osmotic stress", "osmolarity sensing signalling pathway"], "types": ["T044"], "canonical_name": "osmosensory signaling pathway", "definition": "The series of molecular signals initiated in response to osmotic change. [GOC:jl]"}
{"concept_id": "C1155459", "aliases": ["osmosensory signalling pathway via Sho1 osmosensor", "signal transduction during osmotic stress via Sho1 osmosensor"], "types": ["T044"], "canonical_name": "osmosensory signaling pathway via Sho1 osmosensor", "definition": "The series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system. [GOC:jl]"}
{"concept_id": "C1155461", "aliases": ["osmosensory signaling pathway via two-component system", "signal transduction during osmotic stress via two-component system", "osmolarity signalling pathway via two-component system", "osmolarity sensing via two-component system", "osmosensory signalling pathway via two-component system", "osmolarity signaling pathway via two-component system"], "types": ["T044"], "canonical_name": "osmosensory signaling via phosphorelay pathway", "definition": "The series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system. [PMID:9843501]"}
{"concept_id": "C1155462", "aliases": ["MAPKKK cascade involved in osmosensory signaling pathway", "MAPKKK cascade during osmolarity sensing", "MAPKKK cascade involved in osmosensory signalling pathway", "MAPK cascade involved in osmosensory signaling pathway", "osmolarity sensing, MAPKKK cascade"], "types": ["T043"], "canonical_name": "osmosensory signaling MAPK cascade", "definition": "The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K. [PMID:17604854, PMID:9561267]"}
{"concept_id": "C1155468", "aliases": ["hedgehog signaling pathway", "smoothened signalling pathway"], "types": ["T044"], "definition": "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. [GOC:mah, PMID:15205520]", "canonical_name": "smoothened signaling pathway"}
{"concept_id": "C1155470", "aliases": [], "types": ["T044"], "canonical_name": "regulation of smoothened receptor activity by patched"}
{"concept_id": "C1155471", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of smoothened by patched"}
{"concept_id": "C1155472", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of smoothened by patched"}
{"concept_id": "C1155473", "aliases": ["regulation of hh signaling pathway", "regulation of hedgehog signaling pathway", "regulation of smoothened signalling pathway"], "types": ["T044"], "canonical_name": "regulation of smoothened signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of smoothened signaling. [GOC:go_curators]"}
{"concept_id": "C1155476", "aliases": [], "types": ["T044"], "canonical_name": "signal transduction downstream of smoothened", "definition": "The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway. [PMID:15057936]"}
{"concept_id": "C1155477", "aliases": ["activation of hh target transcription factor", "positive regulation of hedgehog target transcription factor"], "types": ["T044"], "canonical_name": "positive regulation of hh target transcription factor activity", "definition": "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited. [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936]"}
{"concept_id": "C1155478", "aliases": ["Tl signalling pathway", "Tl signaling pathway", "Toll signalling pathway"], "types": ["T044"], "canonical_name": "Toll signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:go_curators, PMID:11135568, PMID:19126860]"}
{"concept_id": "C1155479", "aliases": ["regulation of Tl signaling pathway", "regulation of Toll signalling pathway", "regulation of Tl signalling pathway"], "types": ["T044"], "canonical_name": "regulation of Toll signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the Tl signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155480", "aliases": ["down-regulation of Toll signaling pathway", "negative regulation of Tl signalling pathway", "down regulation of Toll signaling pathway", "downregulation of Toll signaling pathway", "negative regulation of Tl signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of Toll signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155481", "aliases": ["upregulation of Toll signaling pathway", "positive regulation of Tl signalling pathway", "positive regulation of Tl signaling pathway", "up regulation of Toll signaling pathway", "up-regulation of Toll signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of Toll signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway. [GOC:go_curators]"}
{"concept_id": "C1155487", "aliases": ["frizzled-2 signaling pathway"], "types": ["T044"], "canonical_name": "frizzled-2 signalling pathway"}
{"concept_id": "C1155488", "aliases": ["regulation of Wnt receptor signaling pathway, calcium modulating pathway", "regulation of frizzled-2 signalling pathway", "regulation of frizzled-2 signaling pathway", "regulation of Wnt-activated signaling pathway, calcium modulating pathway"], "types": ["T044"], "canonical_name": "regulation of Wnt signaling pathway, calcium modulating pathway", "definition": "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155489", "aliases": ["negative regulation of Wnt-activated signaling pathway, calcium modulating pathway", "downregulation of frizzled-2 signaling pathway", "negative regulation of frizzled-2 signaling pathway", "down-regulation of frizzled-2 signaling pathway", "down regulation of frizzled-2 signaling pathway", "negative regulation of Wnt receptor signaling pathway, calcium modulating pathway", "negative regulation of frizzled-2 signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of Wnt signaling pathway, calcium modulating pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155490", "aliases": ["up-regulation of frizzled-2 signaling pathway", "up regulation of frizzled-2 signaling pathway", "positive regulation of frizzled-2 signaling pathway", "positive regulation of Wnt-activated signaling pathway, calcium modulating pathway", "positive regulation of Wnt receptor signaling pathway, calcium modulating pathway", "upregulation of frizzled-2 signaling pathway", "positive regulation of frizzled-2 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of Wnt signaling pathway, calcium modulating pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). [GOC:go_curators]"}
{"concept_id": "C1155491", "aliases": ["regulation of Wnt-activated signaling pathway", "regulation of Wnt receptor signaling pathway", "regulation of frizzled signaling pathway", "regulation of frizzled signalling pathway", "regulation of Wnt receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of Wnt signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1155492", "aliases": ["negative regulation of Wnt-activated signaling pathway", "down-regulation of frizzled signaling pathway", "negative regulation of frizzled signaling pathway", "negative regulation of Wnt receptor signalling pathway", "negative regulation of Wnt receptor signaling pathway", "downregulation of frizzled signaling pathway", "downregulation of Wnt receptor signaling pathway", "down-regulation of Wnt receptor signaling pathway", "negative regulation of frizzled signalling pathway", "down regulation of frizzled signaling pathway", "down regulation of Wnt receptor signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of Wnt signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155493", "aliases": ["up regulation of Wnt receptor signaling pathway", "up regulation of frizzled signaling pathway", "positive regulation of Wnt receptor signaling pathway", "upregulation of frizzled signaling pathway", "positive regulation of Wnt-activated signaling pathway", "positive regulation of Wnt receptor signalling pathway", "positive regulation of frizzled signalling pathway", "up-regulation of Wnt receptor signaling pathway", "upregulation of Wnt receptor signaling pathway", "positive regulation of frizzled signaling pathway", "up-regulation of frizzled signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of Wnt signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155494", "aliases": ["intracellular signaling cascade", "intracellular signaling chain"], "types": ["T044"], "canonical_name": "intracellular signal transduction", "definition": "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]"}
{"concept_id": "C1155495", "aliases": ["blue light signalling pathway"], "types": ["T044"], "canonical_name": "blue light signaling pathway", "definition": "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm. [GOC:lr, GOC:sm]"}
{"concept_id": "C1155497", "aliases": ["intracellular receptor-mediated signaling pathway", "intracellular receptor-mediated signalling pathway", "intracellular receptor mediated signaling pathway"], "types": ["T044"], "canonical_name": "intracellular receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a receptor located within a cell. [GOC:bf, GOC:mah]"}
{"concept_id": "C1155498", "aliases": ["steroid hormone receptor signalling pathway"], "types": ["T044"], "canonical_name": "steroid hormone receptor signaling pathway"}
{"concept_id": "C1155499", "aliases": ["androgen receptor signalling pathway"], "types": ["T044"], "canonical_name": "androgen receptor signaling pathway", "definition": "The series of molecular signals initiated by androgen binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah]"}
{"concept_id": "C1155500", "aliases": ["estrogen receptor signalling pathway"], "types": ["T044"], "canonical_name": "estrogen receptor signaling pathway"}
{"concept_id": "C1155501", "aliases": ["nitric oxide signaling", "NO-mediated signal transduction", "NO mediated signal transduction", "nitric oxide-mediated signal transduction"], "types": ["T044"], "canonical_name": "nitric oxide mediated signal transduction", "definition": "Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. [GOC:jl, PMID:21549190]"}
{"concept_id": "C1155502", "aliases": ["intracellular protein kinase cascade"], "types": ["T044"], "canonical_name": "protein kinase cascade"}
{"concept_id": "C1155503", "aliases": ["JAK-STAT signal transduction", "JAK-STAT cascade"], "types": ["T044"], "canonical_name": "receptor signaling pathway via JAK-STAT", "definition": "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028]"}
{"concept_id": "C1155504", "aliases": [], "types": ["T044"], "canonical_name": "regulation of receptor signaling pathway via JAK-STAT", "definition": "Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT. [GOC:bf]"}
{"concept_id": "C1155505", "aliases": ["down-regulation of JAK-STAT cascade", "down regulation of JAK-STAT cascade", "downregulation of JAK-STAT cascade"], "types": ["T043"], "canonical_name": "negative regulation of receptor signaling pathway via JAK-STAT", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT. [GOC:bf]"}
{"concept_id": "C1155506", "aliases": ["up regulation of JAK-STAT cascade", "upregulation of JAK-STAT cascade", "up-regulation of JAK-STAT cascade"], "types": ["T043"], "canonical_name": "positive regulation of receptor signaling pathway via JAK-STAT", "definition": "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. [GOC:bf]"}
{"concept_id": "C1155507", "aliases": [], "types": ["T044"], "canonical_name": "serine phosphorylation of STAT protein", "definition": "The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:10918594]"}
{"concept_id": "C1155510", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of STAT protein", "definition": "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:10918594]"}
{"concept_id": "C1155511", "aliases": [], "types": ["T043"], "canonical_name": "regulation of tyrosine phosphorylation of STAT protein", "definition": "Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647]"}
{"concept_id": "C1155512", "aliases": ["down regulation of tyrosine phosphorylation of STAT protein", "down-regulation of tyrosine phosphorylation of STAT protein", "downregulation of tyrosine phosphorylation of STAT protein"], "types": ["T043"], "canonical_name": "negative regulation of tyrosine phosphorylation of STAT protein", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647]"}
{"concept_id": "C1155520", "aliases": ["up regulation of tyrosine phosphorylation of STAT protein", "upregulation of tyrosine phosphorylation of STAT protein", "up-regulation of tyrosine phosphorylation of STAT protein"], "types": ["T043"], "canonical_name": "positive regulation of tyrosine phosphorylation of STAT protein", "definition": "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647]"}
{"concept_id": "C1155528", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of Stat1 protein"}
{"concept_id": "C1155529", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of Stat2 protein"}
{"concept_id": "C1155530", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of Stat3 protein"}
{"concept_id": "C1155531", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of Stat4 protein"}
{"concept_id": "C1155532", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of Stat5 protein"}
{"concept_id": "C1155533", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of Stat6 protein"}
{"concept_id": "C1155534", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of Stat7 protein"}
{"concept_id": "C1155535", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of Stat1 protein"}
{"concept_id": "C1155536", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of Stat2 protein"}
{"concept_id": "C1155537", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of Stat3 protein"}
{"concept_id": "C1155538", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of Stat4 protein"}
{"concept_id": "C1155539", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of Stat5 protein"}
{"concept_id": "C1155540", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of Stat6 protein"}
{"concept_id": "C1155541", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of Stat7 protein"}
{"concept_id": "C1155542", "aliases": ["c-Jun N-terminal kinase cascade"], "types": ["T044"], "canonical_name": "JNK cascade", "definition": "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]"}
{"concept_id": "C1155546", "aliases": [], "types": ["T044"], "canonical_name": "JUN phosphorylation", "definition": "The process of introducing a phosphate group into a JUN protein. [GOC:jl]"}
{"concept_id": "C1155547", "aliases": [], "types": ["T044"], "canonical_name": "regulation of JNK cascade", "definition": "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]"}
{"concept_id": "C1155548", "aliases": ["downregulation of JNK cascade", "down regulation of JNK cascade", "down-regulation of JNK cascade"], "types": ["T043"], "canonical_name": "negative regulation of JNK cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]"}
{"concept_id": "C1155549", "aliases": ["up regulation of JNK cascade", "upregulation of JNK cascade", "up-regulation of JNK cascade"], "types": ["T043"], "canonical_name": "positive regulation of JNK cascade", "definition": "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]"}
{"concept_id": "C1155571", "aliases": ["MAPKKK cascade involved in cell wall biogenesis", "cell wall biogenesis, MAPKKK cascade", "MAPK cascade involved in cell wall organization or biogenesis", "cell integrity MAPK pathway", "MAPK cascade involved in cell wall biogenesis"], "types": ["T044"], "canonical_name": "cell wall integrity MAPK cascade", "definition": "A MAPK cascade that contributes to cell wall organization or biogenesis. [PMID:17604854, PMID:9561267]"}
{"concept_id": "C1155573", "aliases": [], "types": ["T044"], "canonical_name": "MAPKKK cascade (pseudohyphal growth)", "definition": "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth. [PMID:9561267]"}
{"concept_id": "C1155580", "aliases": ["I-kappaB kinase/NF-kappaB cascade", "canonical NF-kappaB signaling cascade", "I-kappaB kinase/NF-kappaB signal transduction"], "types": ["T044"], "canonical_name": "I-kappaB kinase/NF-kappaB signaling", "definition": "The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. [GOC:bf, GOC:jl, PMID:12773372, Reactome:R-HSA-209560]"}
{"concept_id": "C1155581", "aliases": ["activation of NIK activity"], "types": ["T044"], "canonical_name": "activation of NF-kappaB-inducing kinase activity", "definition": "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. [GOC:jl, PMID:12773372]"}
{"concept_id": "C1155582", "aliases": [], "types": ["T044"], "canonical_name": "activation of the inhibitor of kappa kinase", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1155583", "aliases": ["cytoplasmic NF-kappaB sequestration", "cytoplasmic sequestration of NF-kappaB", "cytoplasmic storage of NF-kappaB", "cytoplasmic NF-kappaB storage", "maintenance of NF-kappaB location in cytoplasm", "cytoplasmic NF-kappaB retention", "cytoplasmic retention of NF-kappaB"], "types": ["T044"], "canonical_name": "cytoplasmic sequestering of NF-kappaB", "definition": "The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. [GOC:jl]"}
{"concept_id": "C1155584", "aliases": ["IkappaB phosphorylation", "IKB phosphorylation", "inhibitor of kappaB phosphorylation", "inhibitor of NF-kappaB phosphorylation"], "types": ["T044"], "canonical_name": "I-kappaB phosphorylation", "definition": "The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. [GOC:bf, GOC:jl, PMID:21772278, PMID:7594468]"}
{"concept_id": "C1155586", "aliases": ["second messenger-mediated signaling", "second messenger mediated signaling", "second-messenger-mediated signalling", "second messenger-mediated signalling", "second messenger mediated signalling", "second-messenger-mediated signal transduction"], "types": ["T044"], "canonical_name": "second-messenger-mediated signaling", "definition": "Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. [GOC:signaling, ISBN:0815316194, PMID:15221855, Wikipedia:Second_messenger_system]"}
{"concept_id": "C1155588", "aliases": ["cyclic-nucleotide-mediated signalling"], "types": ["T044"], "canonical_name": "cyclic-nucleotide-mediated signaling", "definition": "Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. [GOC:signaling]"}
{"concept_id": "C1155589", "aliases": ["cyclic AMP-mediated signalling", "3',5' cAMP-mediated signalling", "cAMP-mediated signalling", "cAMP signaling", "cyclic AMP-mediated signaling", "cAMP signalling", "cAMP-mediated signal transduction", "3',5'-cAMP-mediated signaling", "3',5' cAMP-mediated signaling", "3',5'-cAMP-mediated signalling", "adenosine 3',5'-cyclophosphate-mediated signalling", "adenosine 3',5'-cyclophosphate-mediated signaling"], "types": ["T044"], "canonical_name": "cAMP-mediated signaling", "definition": "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. [GOC:signaling]"}
{"concept_id": "C1155590", "aliases": ["cGMP-mediated signalling"], "types": ["T044"], "canonical_name": "cGMP-mediated signaling", "definition": "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell. [GOC:signaling]"}
{"concept_id": "C1155591", "aliases": ["phosphoinositide-mediated signalling", "phosphatidylinositol-mediated signalling", "phosphoinositide-mediated signaling", "phosphatidylinositol-mediated signal transduction"], "types": ["T044"], "canonical_name": "phosphatidylinositol-mediated signaling", "definition": "The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, GOC:ceb, ISBN:0198506732]"}
{"concept_id": "C1155592", "aliases": ["inositol lipid-mediated signal transduction", "inositol lipid-mediated signalling"], "types": ["T044"], "canonical_name": "inositol lipid-mediated signaling", "definition": "The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. [GOC:bf, GOC:ceb, PMID:16088939]"}
{"concept_id": "C1155593", "aliases": ["inositol phosphate-mediated signalling"], "types": ["T044"], "canonical_name": "inositol phosphate-mediated signaling", "definition": "A intracellular signal transduction in which the signal is transmitted within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). [GOC:bf, GOC:ceb, GOC:signaling, ISBN:0198506732, PMID:11331907]"}
{"concept_id": "C1155594", "aliases": ["small GTPase-mediated signal transduction"], "types": ["T044"], "canonical_name": "small GTPase mediated signal transduction", "definition": "The series of molecular signals in which a small monomeric GTPase relays a signal. [GOC:mah]"}
{"concept_id": "C1155595", "aliases": ["Rac mediated signal transduction"], "types": ["T044"], "canonical_name": "Rac protein signal transduction", "definition": "The series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. [GOC:bf]"}
{"concept_id": "C1155596", "aliases": ["Ras mediated signal transduction"], "types": ["T044"], "canonical_name": "Ras protein signal transduction", "definition": "The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. [GOC:bf]"}
{"concept_id": "C1155597", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Ras protein signal transduction", "definition": "Any process that modulates the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]"}
{"concept_id": "C1155598", "aliases": ["down regulation of Ras protein signal transduction", "down-regulation of Ras protein signal transduction", "downregulation of Ras protein signal transduction"], "types": ["T043"], "canonical_name": "negative regulation of Ras protein signal transduction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]"}
{"concept_id": "C1155599", "aliases": ["up-regulation of Ras protein signal transduction", "upregulation of Ras protein signal transduction", "up regulation of Ras protein signal transduction"], "types": ["T043"], "canonical_name": "positive regulation of Ras protein signal transduction", "definition": "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]"}
{"concept_id": "C1155600", "aliases": ["Rho mediated signal transduction"], "types": ["T044"], "canonical_name": "Rho protein signal transduction", "definition": "The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. [GOC:bf]"}
{"concept_id": "C1155601", "aliases": ["histidyl-aspartyl phosphorelay"], "types": ["T044"], "canonical_name": "phosphorelay signal transduction system", "definition": "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. [PMID:9191038]"}
{"concept_id": "C1155604", "aliases": [], "types": ["T043"], "definition": "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded. [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]", "canonical_name": "macroautophagy"}
{"concept_id": "C1155605", "aliases": ["autophagic vacuole membrane disassembly", "autophagic membrane breakdown"], "types": ["T043"], "canonical_name": "autophagosome membrane disassembly", "definition": "The controlled breakdown of the membranes of autophagosomes. [GOC:autophagy, GOC:mah]"}
{"concept_id": "C1155606", "aliases": ["autophagic vacuole docking"], "types": ["T043"], "canonical_name": "autophagosome membrane docking", "definition": "The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. [GOC:autophagy, GOC:mah]"}
{"concept_id": "C1155609", "aliases": ["regulation of autophagic vacuole size"], "types": ["T043"], "canonical_name": "regulation of autophagosome size", "definition": "Any process that modulates the size of the autophagosome. [GOC:autophagy, GOC:krc]"}
{"concept_id": "C1155610", "aliases": ["down-regulation of autophagic vacuole size", "negative regulation of autophagic vacuole size", "down regulation of autophagic vacuole size", "downregulation of autophagic vacuole size"], "types": ["T043"], "canonical_name": "negative regulation of autophagosome size", "definition": "Any process that reduces autophagosome size. [GOC:autophagy, GOC:go_curators]"}
{"concept_id": "C1155611", "aliases": ["up-regulation of autophagic vacuole size", "positive regulation of autophagic vacuole size", "up regulation of autophagic vacuole size", "upregulation of autophagic vacuole size"], "types": ["T043"], "canonical_name": "positive regulation of autophagosome size", "definition": "Any process that increases autophagosome size. [GOC:autophagy, GOC:go_curators]"}
{"concept_id": "C1155612", "aliases": ["regulation of starvation-induced autophagy"], "types": ["T043"], "canonical_name": "regulation of macroautophagy", "definition": "Any process that modulates the frequency, rate or extent of macroautophagy. [GOC:krc]"}
{"concept_id": "C1155613", "aliases": ["down regulation of macroautophagy", "negative regulation of starvation-induced autophagy", "down-regulation of macroautophagy", "downregulation of macroautophagy"], "types": ["T043"], "canonical_name": "negative regulation of macroautophagy", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. [GOC:go_curators]"}
{"concept_id": "C1155614", "aliases": ["up regulation of macroautophagy", "up-regulation of macroautophagy", "positive regulation of starvation-induced autophagy", "upregulation of macroautophagy"], "types": ["T043"], "canonical_name": "positive regulation of macroautophagy", "definition": "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. [GOC:go_curators, PMID:9412464]"}
{"concept_id": "C1155615", "aliases": [], "types": ["T043"], "canonical_name": "lysosomal microautophagy", "definition": "The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment. [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964]"}
{"concept_id": "C1155616", "aliases": ["cell budding"], "types": ["T043"], "definition": "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell. [ISBN:0198506732]", "canonical_name": "budding"}
{"concept_id": "C1155617", "aliases": ["axial bud site selection"], "types": ["T043"], "canonical_name": "axial cellular bud site selection", "definition": "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell. [GOC:clt]"}
{"concept_id": "C1155618", "aliases": [], "types": ["T043"], "canonical_name": "budding cell bud growth", "definition": "The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. [GOC:go_curators]"}
{"concept_id": "C1155619", "aliases": [], "types": ["T043"], "canonical_name": "apical bud growth"}
{"concept_id": "C1155620", "aliases": [], "types": ["T043"], "canonical_name": "budding cell isotropic bud growth", "definition": "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding. [GOC:go_curators]"}
{"concept_id": "C1155624", "aliases": ["bipolar bud site selection"], "types": ["T043"], "canonical_name": "bipolar cellular bud site selection", "definition": "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell. [GOC:clt]"}
{"concept_id": "C1155625", "aliases": [], "types": ["T043"], "canonical_name": "regulation of budding"}
{"concept_id": "C1155626", "aliases": ["down-regulation of cell budding", "downregulation of cell budding", "down regulation of cell budding"], "types": ["T043"], "canonical_name": "negative regulation of cell budding", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell budding. [GOC:go_curators]"}
{"concept_id": "C1155627", "aliases": ["up-regulation of cell budding", "up regulation of cell budding", "upregulation of cell budding"], "types": ["T043"], "canonical_name": "positive regulation of cell budding", "definition": "Any process that activates or increases the frequency, rate or extent of cell budding. [GOC:go_curators]"}
{"concept_id": "C1155628", "aliases": [], "types": ["T043"], "canonical_name": "actin filament reorganization during cell cycle"}
{"concept_id": "C1155631", "aliases": ["nuclear chromosome condensation", "eukaryotic chromosome condensation"], "types": ["T043"], "definition": "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. [GOC:mah, ISBN:0815316194]", "canonical_name": "chromosome condensation"}
{"concept_id": "C1155632", "aliases": [], "types": ["T043"], "canonical_name": "mitotic chromosome condensation", "definition": "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1155633", "aliases": ["coheson-mediated DNA tethering"], "types": ["T043"], "canonical_name": "sister chromatid cohesion", "definition": "The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. [GOC:jh, GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1155634", "aliases": [], "types": ["T043"], "canonical_name": "female meiosis sister chromatid cohesion", "definition": "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female. [GOC:ai]"}
{"concept_id": "C1155635", "aliases": [], "types": ["T043"], "canonical_name": "male meiosis sister chromatid cohesion", "definition": "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male. [GOC:ai]"}
{"concept_id": "C1155637", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sister chromatid cohesion", "definition": "Any process that modulates the frequency, rate or extent of sister chromatid cohesion. [GOC:go_curators]"}
{"concept_id": "C1155638", "aliases": ["down regulation of sister chromatid cohesion", "down-regulation of sister chromatid cohesion", "downregulation of sister chromatid cohesion"], "types": ["T043"], "canonical_name": "negative regulation of sister chromatid cohesion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion. [GOC:go_curators]"}
{"concept_id": "C1155639", "aliases": ["up-regulation of sister chromatid cohesion", "up regulation of sister chromatid cohesion", "upregulation of sister chromatid cohesion"], "types": ["T043"], "canonical_name": "positive regulation of sister chromatid cohesion", "definition": "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion. [GOC:go_curators]"}
{"concept_id": "C1155641", "aliases": [], "types": ["T043"], "canonical_name": "meiotic chromosome segregation", "definition": "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. [GOC:ai, GOC:mah]"}
{"concept_id": "C1155642", "aliases": [], "types": ["T043"], "canonical_name": "female meiosis chromosome segregation", "definition": "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. [GOC:ai]"}
{"concept_id": "C1155643", "aliases": [], "types": ["T043"], "canonical_name": "male meiosis chromosome segregation", "definition": "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male. [GOC:ai]"}
{"concept_id": "C1155644", "aliases": ["meiosis I, chromosome segregation"], "types": ["T043"], "canonical_name": "homologous chromosome segregation", "definition": "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. [GOC:ai, ISBN:0815316194]"}
{"concept_id": "C1155645", "aliases": ["meiosis II, chromosome segregation"], "types": ["T043"], "canonical_name": "meiotic sister chromatid segregation", "definition": "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle. [GOC:ai, ISBN:0815316194]"}
{"concept_id": "C1155646", "aliases": ["mitotic chromosome segregation"], "types": ["T043"], "canonical_name": "mitotic sister chromatid segregation", "definition": "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. [GOC:ai, GOC:jl]"}
{"concept_id": "C1155647", "aliases": ["DNA-dependent DNA replication"], "types": ["T045"], "canonical_name": "DNA-templated DNA replication", "definition": "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1155648", "aliases": ["DNA re-duplication", "DNA endoreplication"], "types": ["T045"], "canonical_name": "DNA endoreduplication", "definition": "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes. [GOC:jl, GOC:vw]"}
{"concept_id": "C1155649", "aliases": [], "types": ["T045"], "definition": "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. [ISBN:0815316194]", "canonical_name": "DNA ligation"}
{"concept_id": "C1155650", "aliases": ["DNA replication initiation"], "types": ["T045"], "definition": "The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. [ISBN:071673706X, ISBN:0815316194, PMID:28209641]", "canonical_name": "DNA-dependent DNA replication initiation"}
{"concept_id": "C1155651", "aliases": ["DNA re-replication initiation"], "types": ["T045"], "canonical_name": "DNA endoreduplication initiation"}
{"concept_id": "C1155652", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication termination", "definition": "The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. [GOC:mah, PMID:10209736, PMID:12009298]"}
{"concept_id": "C1155654", "aliases": ["DNA replication elongation"], "types": ["T045"], "canonical_name": "DNA strand elongation involved in DNA replication", "definition": "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. [GOC:mah, ISBN:071673706X, ISBN:0815316194]"}
{"concept_id": "C1155655", "aliases": [], "types": ["T045"], "canonical_name": "lagging strand elongation", "definition": "The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. [GOC:mah, ISBN:071673706X, ISBN:0815316194]"}
{"concept_id": "C1155656", "aliases": [], "types": ["T045"], "canonical_name": "leading strand elongation", "definition": "The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork. [GOC:mah, ISBN:071673706X, ISBN:0815316194]"}
{"concept_id": "C1155657", "aliases": [], "types": ["T045"], "canonical_name": "DNA topological change", "definition": "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. [ISBN:071673706X, ISBN:0935702490]"}
{"concept_id": "C1155658", "aliases": [], "types": ["T045"], "canonical_name": "DNA unwinding during replication"}
{"concept_id": "C1155659", "aliases": [], "types": ["T045"], "canonical_name": "maintenance of fidelity during DNA-dependent DNA replication"}
{"concept_id": "C1155660", "aliases": [], "types": ["T045"], "definition": "Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity. [GOC:ai]", "canonical_name": "DNA replication proofreading"}
{"concept_id": "C1155661", "aliases": ["mismatch repair"], "types": ["T045"], "definition": "A DNA repair pathway involved in correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. Excinucleases recognize the BASE PAIR MISMATCH and cause a segment of polynucleotide chain to be excised from the daughter strand, thereby removing the mismatched base. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)", "canonical_name": "MMR"}
{"concept_id": "C1155665", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA replication", "definition": "Any process that modulates the frequency, rate or extent of DNA replication. [GOC:go_curators]"}
{"concept_id": "C1155666", "aliases": ["DNA replication licencing", "regulation of DNA-dependent DNA replication initiation", "DNA replication licensing"], "types": ["T045"], "canonical_name": "regulation of DNA-templated DNA replication initiation", "definition": "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. [GOC:mah]"}
{"concept_id": "C1155667", "aliases": ["down regulation of DNA replication", "down-regulation of DNA replication", "downregulation of DNA replication"], "types": ["T045"], "canonical_name": "negative regulation of DNA replication", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. [GOC:go_curators]"}
{"concept_id": "C1155668", "aliases": ["up-regulation of DNA replication", "upregulation of DNA replication", "up regulation of DNA replication"], "types": ["T043"], "canonical_name": "positive regulation of DNA replication", "definition": "Any process that activates or increases the frequency, rate or extent of DNA replication. [GOC:go_curators]"}
{"concept_id": "C1155669", "aliases": ["meiotic nuclear cell cycle DNA replication", "meiotic cell cycle DNA replication", "DNA replication involved in S phase involved in meiotic cell cycle", "DNA replication involved in S-phase involved in meiotic cell cycle", "nuclear cell cycle DNA replication involved in meiotic cell cycle"], "types": ["T045"], "canonical_name": "premeiotic DNA replication", "definition": "The replication of DNA that precedes meiotic cell division. [GO_REF:0000060, GOC:ai, GOC:TermGenie]"}
{"concept_id": "C1155670", "aliases": ["RNA-dependent DNA biosynthetic process"], "types": ["T045"], "canonical_name": "RNA-templated DNA biosynthetic process", "definition": "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1155671", "aliases": [], "types": ["T045"], "canonical_name": "plasmid maintenance", "definition": "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division. [GOC:ai]"}
{"concept_id": "C1155672", "aliases": [], "types": ["T043"], "canonical_name": "plasmid partitioning", "definition": "Any process in which plasmids are segregated or distributed into daughter cells upon cell division. [GOC:mah]"}
{"concept_id": "C1155673", "aliases": [], "types": ["T043"], "canonical_name": "2-micrometer plasmid partitioning", "definition": "The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division. [GOC:mah]"}
{"concept_id": "C1155676", "aliases": ["spindle assembly involved in mitosis"], "types": ["T043"], "canonical_name": "mitotic spindle assembly", "definition": "Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. [GOC:tb, GOC:vw]"}
{"concept_id": "C1155678", "aliases": ["spindle positioning involved in mitotic cell cycle", "establishment of mitotic spindle localisation", "mitotic spindle positioning or orientation", "mitotic spindle positioning and orientation", "spindle positioning during mitosis", "mitotic spindle positioning"], "types": ["T043"], "definition": "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. [GOC:ai]", "canonical_name": "establishment of mitotic spindle localization"}
{"concept_id": "C1155684", "aliases": ["microtubule-dependent nucleus positioning", "microtubule-dependent nuclear positioning", "nuclear migration, microtubule-mediated", "microtubule cytoskeleton-dependent nucleus positioning", "transport of nucleus, microtubule-mediated", "microtubule cytoskeleton-dependent nuclear positioning", "transport of nucleus by microtubules", "microtubule-mediated nuclear migration"], "types": ["T043"], "canonical_name": "nuclear migration along microtubule", "definition": "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. [GOC:mah, GOC:sgd_curators]"}
{"concept_id": "C1155688", "aliases": [], "types": ["T043"], "canonical_name": "initial mitotic spindle pole body separation", "definition": "The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel sliding apart of microtubules promotes the initial separation of the SPB. [GOC:sgd_curators, GOC:vw]"}
{"concept_id": "C1155689", "aliases": ["spindle pole body duplication associated with nuclear envelope", "spindle pole body formation", "spindle pole body replication", "spindle pole body assembly", "spindle pole body duplication in cytoplasm", "spindle pole body biosynthesis", "spindle pole body biogenesis"], "types": ["T043"], "canonical_name": "spindle pole body duplication", "definition": "Construction of a new spindle pole body. [GOC:clt]"}
{"concept_id": "C1155691", "aliases": ["endomitosis"], "types": ["T043"], "canonical_name": "endomitotic cell cycle", "definition": "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. [GOC:curators, GOC:dos, GOC:expert_vm]"}
{"concept_id": "C1155692", "aliases": ["asymmetrical cell division"], "types": ["T043"], "definition": "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. [PMID:11672519]", "canonical_name": "asymmetric cell division"}
{"concept_id": "C1155693", "aliases": ["cystoblast cell division"], "types": ["T043"], "canonical_name": "cystoblast division", "definition": "Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells. [PMID:21452446]"}
{"concept_id": "C1155694", "aliases": ["neuroblast cell division"], "types": ["T043"], "canonical_name": "neuroblast division", "definition": "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. [PMID:11163136, PMID:11250167]"}
{"concept_id": "C1155695", "aliases": [], "types": ["T043"], "canonical_name": "regulation of asymmetric cell division", "definition": "Any process that modulates the frequency, rate or extent of asymmetric cell division. [GOC:lr]"}
{"concept_id": "C1155696", "aliases": ["downregulation of asymmetric cell division", "down-regulation of asymmetric cell division", "down regulation of asymmetric cell division"], "types": ["T043"], "canonical_name": "negative regulation of asymmetric cell division", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division. [GOC:go_curators]"}
{"concept_id": "C1155697", "aliases": ["upregulation of asymmetric cell division", "up-regulation of asymmetric cell division", "up regulation of asymmetric cell division"], "types": ["T043"], "canonical_name": "positive regulation of asymmetric cell division", "definition": "Any process that activates or increases the frequency, rate or extent of asymmetric cell division. [GOC:go_curators]"}
{"concept_id": "C1155698", "aliases": ["sense organ precursor cell division"], "types": ["T043"], "canonical_name": "sensory organ precursor cell division", "definition": "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron). [GOC:mah, PMID:11171389, PMID:18295597]"}
{"concept_id": "C1155699", "aliases": [], "types": ["T043"], "canonical_name": "cytokinesis by cell plate formation", "definition": "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana. [GOC:clt]"}
{"concept_id": "C1155700", "aliases": ["cytokinesis after meiosis I"], "types": ["T043"], "canonical_name": "meiosis I cytokinesis", "definition": "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155701", "aliases": ["cytokinesis after meiosis II"], "types": ["T043"], "canonical_name": "meiosis II cytokinesis", "definition": "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155702", "aliases": ["cytokinesis after mitosis"], "types": ["T043"], "canonical_name": "mitotic cytokinesis", "definition": "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155706", "aliases": ["cytokinesis, membrane recruitment/generation"], "types": ["T043"], "canonical_name": "membrane addition at site of cytokinesis", "definition": "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion. [GOC:clt]"}
{"concept_id": "C1155708", "aliases": ["contractile ring positioning"], "types": ["T043"], "canonical_name": "actomyosin ring positioning"}
{"concept_id": "C1155709", "aliases": ["cytokinesis involved in male meiotic cell cycle", "cytokinesis after male meiosis"], "types": ["T043"], "canonical_name": "male meiosis cytokinesis", "definition": "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells. [GOC:ai]"}
{"concept_id": "C1155710", "aliases": ["septin assembly and septum formation"], "types": ["T043"], "canonical_name": "septin assembly and septum formation", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1155711", "aliases": ["stem cell renewal"], "types": ["T043"], "definition": "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. [GOC:jid, ISBN:0582227089]", "canonical_name": "stem cell division"}
{"concept_id": "C1155712", "aliases": ["germ-line stem cell renewal"], "types": ["T043"], "canonical_name": "germ-line stem cell division", "definition": "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. [GOC:jid, PMID:2279698]"}
{"concept_id": "C1155713", "aliases": ["spermatogonium division"], "types": ["T043"], "canonical_name": "spermatogonial cell division", "definition": "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes). [GOC:bf, GOC:pr, ISBN:0879694238]"}
{"concept_id": "C1155715", "aliases": [], "types": ["T043"], "canonical_name": "activation of transcription on exit from mitosis"}
{"concept_id": "C1155716", "aliases": ["activation of transcription on exit from mitosis, from Pol I promoter"], "types": ["T043"], "canonical_name": "activation of transcription on exit from mitosis, from RNA polymerase I promoter"}
{"concept_id": "C1155717", "aliases": ["activation of transcription on exit from mitosis, from Pol II promoter"], "types": ["T043"], "canonical_name": "activation of transcription on exit from mitosis, from RNA polymerase II promoter"}
{"concept_id": "C1155718", "aliases": ["activation of transcription on exit from mitosis, from Pol III promoter"], "types": ["T043"], "canonical_name": "activation of transcription on exit from mitosis, from RNA polymerase III promoter"}
{"concept_id": "C1155720", "aliases": [], "types": ["T043"], "canonical_name": "mitotic anaphase A", "definition": "The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155721", "aliases": [], "types": ["T043"], "canonical_name": "mitotic anaphase B", "definition": "The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155722", "aliases": ["mitotic chromosome movement to spindle pole", "sister chromosome movement towards spindle pole during mitosis", "chromosome migration to spindle pole during mitosis", "chromosome movement towards spindle pole during mitosis", "mitotic sister chromosome movement towards spindle pole"], "types": ["T043"], "canonical_name": "mitotic chromosome movement towards spindle pole", "definition": "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis. [GOC:ai]"}
{"concept_id": "C1155724", "aliases": [], "types": ["T043"], "canonical_name": "mitotic metaphase plate congression", "definition": "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1155725", "aliases": ["metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process", "mitotic metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "metaphase/anaphase transition of mitotic cell cycle", "definition": "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. [GOC:mtg_cell_cycle, PMID:10465783]"}
{"concept_id": "C1155727", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic metaphase/anaphase transition", "definition": "Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. [GOC:mah]"}
{"concept_id": "C1155728", "aliases": [], "types": ["T043"], "canonical_name": "APC activation"}
{"concept_id": "C1155729", "aliases": ["downregulation of mitotic metaphase/anaphase transition", "down regulation of mitotic metaphase/anaphase transition", "down-regulation of mitotic metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "negative regulation of mitotic metaphase/anaphase transition", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. [GOC:go_curators]"}
{"concept_id": "C1155730", "aliases": ["up-regulation of mitotic metaphase/anaphase transition", "upregulation of mitotic metaphase/anaphase transition", "up regulation of mitotic metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "positive regulation of mitotic metaphase/anaphase transition", "definition": "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. [GOC:go_curators]"}
{"concept_id": "C1155731", "aliases": [], "types": ["T043"], "canonical_name": "mitotic prometaphase", "definition": "The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155732", "aliases": [], "types": ["T043"], "definition": "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. [GOC:mtg_cell_cycle]", "canonical_name": "mitotic prophase"}
{"concept_id": "C1155733", "aliases": ["mitotic nuclear envelope degradation", "mitotic nuclear envelope catabolism", "mitotic nuclear envelope breakdown", "mitotic nuclear envelope disassembly", "nuclear envelope breakdown", "NEB"], "types": ["T043"], "definition": "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. [GOC:bf, PMID:32848252]", "canonical_name": "mitotic nuclear membrane disassembly"}
{"concept_id": "C1155734", "aliases": [], "types": ["T043"], "canonical_name": "lamin depolymerization", "definition": "The cell cycle process in which lamin is depolymerized. [GOC:jid]"}
{"concept_id": "C1155736", "aliases": ["spindle elongation during mitosis"], "types": ["T043"], "canonical_name": "mitotic spindle elongation", "definition": "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B. [GOC:mtg_cell_cycle, GOC:vw, PMID:19686686]"}
{"concept_id": "C1155738", "aliases": ["establishment of spindle orientation involved in mitotic cell cycle", "orienting of mitotic spindle", "establishment of spindle orientation during mitosis", "mitotic spindle orientation"], "types": ["T043"], "canonical_name": "establishment of mitotic spindle orientation", "definition": "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. [GOC:ems]"}
{"concept_id": "C1155740", "aliases": [], "types": ["T043"], "definition": "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. [GOC:mtg_cell_cycle]", "canonical_name": "mitotic telophase"}
{"concept_id": "C1155742", "aliases": [], "types": ["T043"], "canonical_name": "mitotic nuclear envelope reassembly"}
{"concept_id": "C1155743", "aliases": [], "types": ["T043"], "canonical_name": "nuclear membrane vesicle binding to chromatin", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1155745", "aliases": [], "types": ["T043"], "canonical_name": "mitotic nuclear pore complex reassembly", "definition": "The cell cycle process in which nuclear pore complexes reform during mitotic cell division. [GOC:ai]"}
{"concept_id": "C1155746", "aliases": ["regulation of mitosis"], "types": ["T043"], "canonical_name": "regulation of mitotic nuclear division", "definition": "Any process that modulates the frequency, rate or extent of mitosis. [GOC:go_curators]"}
{"concept_id": "C1155747", "aliases": [], "types": ["T043"], "canonical_name": "regulation of exit from mitosis", "definition": "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. [GOC:rn]"}
{"concept_id": "C1155748", "aliases": [], "types": ["T043"], "canonical_name": "mitotic checkpoint"}
{"concept_id": "C1155750", "aliases": ["mitotic cell cycle spindle checkpoint", "mitotic spindle checkpoint signaling", "mitotic spindle checkpoint", "signal transduction involved in mitotic cell cycle spindle checkpoint"], "types": ["T043"], "definition": "A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form. [GOC:mtg_cell_cycle]", "canonical_name": "signal transduction involved in mitotic spindle checkpoint"}
{"concept_id": "C1155766", "aliases": ["centrosome organisation", "centrosome organization"], "types": ["T043"], "canonical_name": "centrosome cycle", "definition": "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. [ISBN:0815316194]"}
{"concept_id": "C1155767", "aliases": ["centriole duplication"], "types": ["T043"], "canonical_name": "centriole replication", "definition": "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0. [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]"}
{"concept_id": "C1155768", "aliases": [], "types": ["T043"], "canonical_name": "regulation of centriole replication", "definition": "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. [GOC:ai]"}
{"concept_id": "C1155769", "aliases": ["downregulation of centriole replication", "down-regulation of centriole replication", "down regulation of centriole replication"], "types": ["T043"], "canonical_name": "negative regulation of centriole replication", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication. [GOC:ai]"}
{"concept_id": "C1155770", "aliases": ["upregulation of centriole replication", "up-regulation of centriole replication", "up regulation of centriole replication"], "types": ["T045"], "canonical_name": "positive regulation of centriole replication", "definition": "Any process that activates or increases the frequency, rate or extent of centriole replication. [GOC:ai]"}
{"concept_id": "C1155771", "aliases": [], "types": ["T043"], "canonical_name": "mitotic centrosome separation", "definition": "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. [ISBN:0815316194]"}
{"concept_id": "C1155776", "aliases": [], "types": ["T043"], "canonical_name": "regulation of centrosome cycle", "definition": "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. [GOC:ai]"}
{"concept_id": "C1155777", "aliases": ["down regulation of centrosome cycle", "down-regulation of centrosome cycle", "downregulation of centrosome cycle"], "types": ["T043"], "canonical_name": "negative regulation of centrosome cycle", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle. [GOC:ai]"}
{"concept_id": "C1155778", "aliases": ["up-regulation of centrosome cycle", "upregulation of centrosome cycle", "up regulation of centrosome cycle"], "types": ["T043"], "canonical_name": "positive regulation of centrosome cycle", "definition": "Any process that activates or increases the frequency, rate or extent of the centrosome cycle. [GOC:ai]"}
{"concept_id": "C1155779", "aliases": ["microtubule/chromatin interaction"], "types": ["T043"], "canonical_name": "microtubule/chromatin interaction", "definition": "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins. [PMID:10322137]"}
{"concept_id": "C1155780", "aliases": ["bipolar attachment", "kinetochore microtubule interaction", "microtubule capture", "microtubule and kinetochore interaction"], "types": ["T043"], "canonical_name": "kinetochore-microtubule interaction"}
{"concept_id": "C1155781", "aliases": ["spindle biosynthesis", "bipolar spindle biosynthesis", "bipolar spindle formation", "spindle formation"], "types": ["T043"], "canonical_name": "spindle assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C1155789", "aliases": ["karyokinesis"], "types": ["T043"], "definition": "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. [GOC:mah]", "canonical_name": "nuclear division"}
{"concept_id": "C1155790", "aliases": ["female meiosis"], "types": ["T043"], "canonical_name": "female meiotic division"}
{"concept_id": "C1155791", "aliases": ["female meiosis I nuclear division"], "types": ["T043"], "canonical_name": "female meiosis I", "definition": "The cell cycle process in which the first meiotic division occurs in the female germline. [GOC:mah]"}
{"concept_id": "C1155792", "aliases": ["reciprocal meiotic recombination"], "types": ["T043"], "definition": "The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. [PMID:2087779]", "canonical_name": "gene conversion with reciprocal crossover"}
{"concept_id": "C1155793", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA double-strand break formation", "definition": "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination. [GOC:elh, GOC:jl, PMID:11529427]"}
{"concept_id": "C1155794", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA double-strand break processing", "definition": "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis. [GOC:elh, PMID:9334324]"}
{"concept_id": "C1155795", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA recombinase assembly", "definition": "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA. [GOC:elh, PMID:11459983]"}
{"concept_id": "C1155796", "aliases": [], "types": ["T043"], "canonical_name": "meiotic recombination nodule assembly", "definition": "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes. [GOC:jl, PMID:9334324]"}
{"concept_id": "C1155797", "aliases": [], "types": ["T043"], "canonical_name": "early meiotic recombination nodule assembly", "definition": "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene. [GOC:jl, PMID:9334324]"}
{"concept_id": "C1155798", "aliases": [], "types": ["T043"], "canonical_name": "late meiotic recombination nodule assembly", "definition": "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over. [GOC:jl, PMID:9334324]"}
{"concept_id": "C1155799", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA repair synthesis", "definition": "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template. [GOC:elh, PMID:9334324]"}
{"concept_id": "C1155800", "aliases": [], "types": ["T045"], "canonical_name": "meiotic joint molecule formation", "definition": "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA. [GOC:elh, PMID:8521495]"}
{"concept_id": "C1155801", "aliases": [], "types": ["T045"], "canonical_name": "meiotic mismatch repair", "definition": "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. [GOC:elh, PMID:10357855]"}
{"concept_id": "C1155802", "aliases": [], "types": ["T045"], "canonical_name": "meiotic D-loop formation"}
{"concept_id": "C1155803", "aliases": ["resolution of meiotic joint molecules as recombinants"], "types": ["T045"], "canonical_name": "resolution of meiotic recombination intermediates", "definition": "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged. [GOC:elh, PMID:11733053]"}
{"concept_id": "C1155805", "aliases": ["female meiosis II nuclear division"], "types": ["T043"], "canonical_name": "female meiosis II", "definition": "The cell cycle process in which the second meiotic division occurs in the female germline. [GOC:mah]"}
{"concept_id": "C1155806", "aliases": ["chromosome movement towards spindle pole during female meiosis", "female meiotic chromosome movement to spindle pole"], "types": ["T043"], "canonical_name": "female meiotic chromosome movement towards spindle pole", "definition": "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis. [GOC:ai]"}
{"concept_id": "C1155807", "aliases": [], "types": ["T043"], "canonical_name": "polar body extrusion after meiotic divisions", "definition": "The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes. [GOC:ems, ISBN:0198506732]"}
{"concept_id": "C1155808", "aliases": [], "types": ["T043"], "canonical_name": "male meiosis"}
{"concept_id": "C1155809", "aliases": ["male meiosis I nuclear division"], "types": ["T043"], "canonical_name": "male meiosis I", "definition": "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. [GOC:dph, GOC:mah]"}
{"concept_id": "C1155810", "aliases": ["male meiosis II nuclear division"], "types": ["T043"], "canonical_name": "male meiosis II", "definition": "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline. [GOC:dph, GOC:mah]"}
{"concept_id": "C1155811", "aliases": ["male meiotic chromosome movement to spindle pole", "chromosome movement towards spindle pole during male meiosis"], "types": ["T043"], "canonical_name": "male meiotic chromosome movement towards spindle pole", "definition": "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis. [GOC:ai]"}
{"concept_id": "C1155812", "aliases": ["meiosis I nuclear division"], "types": ["T043"], "canonical_name": "meiosis I", "definition": "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei. [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324]"}
{"concept_id": "C1155813", "aliases": ["achiasmate meiosis I nuclear division"], "types": ["T043"], "canonical_name": "achiasmate meiosis I", "definition": "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata. [GOC:elh, GOC:sart, PMID:10690419]"}
{"concept_id": "C1155814", "aliases": [], "types": ["T043"], "canonical_name": "meiotic anaphase I", "definition": "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155815", "aliases": ["chromosome movement towards spindle pole during meiosis", "chromosome migration to spindle pole during meiosis", "meiotic chromosome movement to spindle pole"], "types": ["T043"], "canonical_name": "meiotic chromosome movement towards spindle pole", "definition": "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis. [GOC:ai]"}
{"concept_id": "C1155816", "aliases": ["meiotic G2/MI transition", "meiotic cell cycle G2/MI phase transition", "meiotic G2/MI phase transition"], "types": ["T043"], "canonical_name": "G2/MI transition of meiotic cell cycle", "definition": "The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I. [PMID:15084480]"}
{"concept_id": "C1155817", "aliases": [], "types": ["T043"], "canonical_name": "meiotic metaphase I", "definition": "The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155818", "aliases": [], "types": ["T043"], "definition": "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. [GOC:mtg_cell_cycle]", "canonical_name": "meiotic prophase I"}
{"concept_id": "C1155819", "aliases": [], "types": ["T043"], "definition": "The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred. [GOC:mtg_cell_cycle]", "canonical_name": "diakinesis"}
{"concept_id": "C1155820", "aliases": [], "types": ["T043"], "canonical_name": "diplotene", "definition": "The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155821", "aliases": [], "types": ["T043"], "canonical_name": "leptotene", "definition": "The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155823", "aliases": ["gene conversion without reciprocal crossover"], "types": ["T045"], "canonical_name": "meiotic gene conversion", "definition": "The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele. [ISBN:0815316194]"}
{"concept_id": "C1155824", "aliases": [], "types": ["T045"], "canonical_name": "meiotic heteroduplex formation", "definition": "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. [GOC:elh, PMID:9334324]"}
{"concept_id": "C1155825", "aliases": [], "types": ["T045"], "canonical_name": "meiotic strand displacement", "definition": "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis. [GOC:elh, PMID:10357855]"}
{"concept_id": "C1155826", "aliases": [], "types": ["T043"], "canonical_name": "pachytene", "definition": "The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155827", "aliases": [], "types": ["T043"], "canonical_name": "zygotene", "definition": "The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155828", "aliases": ["synaptonemal complex formation"], "types": ["T043"], "canonical_name": "synaptonemal complex assembly", "definition": "The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination. [ISBN:0198506732]"}
{"concept_id": "C1155829", "aliases": [], "types": ["T043"], "canonical_name": "meiotic telophase I", "definition": "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155830", "aliases": ["meiosis II nuclear division"], "types": ["T043"], "canonical_name": "meiosis II", "definition": "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II. [GOC:dph, GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1155831", "aliases": [], "types": ["T043"], "canonical_name": "meiotic anaphase II", "definition": "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155832", "aliases": [], "types": ["T043"], "canonical_name": "meiotic metaphase II", "definition": "The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155833", "aliases": [], "types": ["T043"], "canonical_name": "meiotic prophase II", "definition": "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155834", "aliases": [], "types": ["T043"], "canonical_name": "meiotic telophase II", "definition": "The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155835", "aliases": [], "types": ["T043"], "canonical_name": "regulation of meiosis"}
{"concept_id": "C1155836", "aliases": ["entry into meiotic cell cycle", "conversion to meiotic cell cycle", "initiation of meiotic cell cycle"], "types": ["T043"], "canonical_name": "cell cycle switching, mitotic to meiotic cell cycle", "definition": "The process in which a cell switches cell cycle mode from mitotic to meiotic division. [GOC:ai, GOC:mtg_cell_cycle]"}
{"concept_id": "C1155839", "aliases": [], "types": ["T043"], "definition": "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278]", "canonical_name": "mitotic cell cycle"}
{"concept_id": "C1155840", "aliases": ["G1 phase of mitotic cell cycle"], "types": ["T043"], "canonical_name": "mitotic G1 phase", "definition": "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155842", "aliases": [], "types": ["T043"], "canonical_name": "traversing start control point of mitotic cell cycle", "definition": "A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155843", "aliases": [], "types": ["T043"], "canonical_name": "G1/S transition of mitotic cell cycle", "definition": "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155845", "aliases": ["regulation of cyclin-dependent protein kinase activity", "regulation of CDK activity"], "types": ["T043"], "canonical_name": "regulation of cyclin-dependent protein serine/threonine kinase activity", "definition": "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr]"}
{"concept_id": "C1155847", "aliases": [], "types": ["T043"], "definition": "Any process that activates or increases the frequency, rate or extent of CDK activity. [GOC:go_curators, GOC:pr]", "canonical_name": "positive regulation of cyclin-dependent protein serine/threonine kinase activity"}
{"concept_id": "C1155850", "aliases": ["mitotic G2/M transition"], "types": ["T043"], "canonical_name": "G2/M transition of mitotic cell cycle", "definition": "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155851", "aliases": [], "types": ["T043"], "canonical_name": "G2/M-specific transcription in mitotic cell cycle"}
{"concept_id": "C1155853", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cell cycle, embryonic", "definition": "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo. [GOC:go_curators]"}
{"concept_id": "C1155854", "aliases": ["regulation of progression through embryonic mitotic cell cycle", "regulation of embryonic mitotic cell cycle progression", "embryonic mitotic cell cycle regulation", "embryonic mitotic cell cycle modulation", "regulation of embryonic mitotic cell cycle", "modulation of embryonic mitotic cell cycle progression"], "types": ["T043"], "canonical_name": "regulation of mitotic cell cycle, embryonic", "definition": "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155858", "aliases": ["upregulation of mitotic cell cycle, embryonic", "up regulation of mitotic cell cycle, embryonic", "up-regulation of mitotic cell cycle, embryonic", "positive regulation of embryonic mitotic cell cycle progression", "positive regulation of embryonic mitotic cell cycle", "positive regulation of progression through embryonic mitotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of mitotic cell cycle, embryonic", "definition": "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155861", "aliases": ["regulation of progression through preblastoderm mitotic cell cycle", "preblastoderm mitotic cell cycle modulation", "regulation of preblastoderm mitotic cell cycle progression", "preblastoderm mitotic cell cycle regulation", "modulation of preblastoderm mitotic cell cycle progression"], "types": ["T043"], "canonical_name": "regulation of preblastoderm mitotic cell cycle", "definition": "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155863", "aliases": ["mitotic cell cycle regulation", "regulation of mitotic cell cycle progression", "regulation of progression through mitotic cell cycle", "mitotic cell cycle modulation", "modulation of mitotic cell cycle progression"], "types": ["T043"], "canonical_name": "regulation of mitotic cell cycle", "definition": "Any process that modulates the rate or extent of progress through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155864", "aliases": ["down regulation of progression through mitotic cell cycle", "downregulation of progression through mitotic cell cycle", "negative regulation of mitotic cell cycle progression", "negative regulation of progression through mitotic cell cycle", "down-regulation of progression through mitotic cell cycle"], "types": ["T043"], "canonical_name": "negative regulation of mitotic cell cycle", "definition": "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155866", "aliases": ["upregulation of progression through mitotic cell cycle", "positive regulation of mitotic cell cycle progression", "positive regulation of progression through mitotic cell cycle", "up-regulation of progression through mitotic cell cycle", "up regulation of progression through mitotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of mitotic cell cycle", "definition": "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1155869", "aliases": ["S phase of mitotic cell cycle", "S-phase of mitotic cell cycle"], "types": ["T043"], "canonical_name": "mitotic S phase", "definition": "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1155871", "aliases": ["positioning of nucleus", "nuclear movement", "nucleus positioning", "nuclear positioning", "nucleus migration", "establishment of position of nucleus"], "types": ["T043"], "canonical_name": "nuclear migration", "definition": "The directed movement of the nucleus to a specific location within a cell. [GOC:ai]"}
{"concept_id": "C1155872", "aliases": ["regulation of cell cycle", "regulation of cell cycle progression", "regulation of cell cycle process", "modulation of cell cycle progression", "control of cell cycle progression", "cell cycle regulation", "cell cycle modulation"], "types": ["T043"], "definition": "Any process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]", "canonical_name": "regulation of progression through cell cycle"}
{"concept_id": "C1155873", "aliases": [], "types": ["T043"], "definition": "The halting of progression of a cell through the CELL CYCLE when events in the CELL DIVISION process are not completed accurately or damage to cell components in the process are detected.", "canonical_name": "cell cycle arrest"}
{"concept_id": "C1155874", "aliases": ["cell cycle checkpoint", "signal transduction involved in G2/M transition checkpoint", "signal transduction involved in cell cycle checkpoint"], "types": ["T043"], "definition": "Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or \"arrested\") until the processes are completed and growth conditions are suitable.", "canonical_name": "cell cycle checkpoint signaling"}
{"concept_id": "C1155876", "aliases": ["signal transduction involved in DNA replication checkpoint", "DNA replication checkpoint"], "types": ["T043"], "canonical_name": "DNA replication checkpoint signaling", "definition": "A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518]"}
{"concept_id": "C1155881", "aliases": [], "types": ["T043"], "canonical_name": "re-entry into mitotic cell cycle", "definition": "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state. [GOC:krc]"}
{"concept_id": "C1155882", "aliases": [], "types": ["T043"], "canonical_name": "G0 to G1 transition", "definition": "The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression. [GOC:mtg_cell_cycle, ISBN:0716731363]"}
{"concept_id": "C1155883", "aliases": [], "types": ["T043"], "canonical_name": "schizogony", "definition": "Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously. [GOC:mb]"}
{"concept_id": "C1155885", "aliases": [], "types": ["T042"], "canonical_name": "antral ovarian follicle growth", "definition": "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]"}
{"concept_id": "C1155886", "aliases": ["ovarian cumulus cell differentiation"], "types": ["T042"], "canonical_name": "cumulus cell differentiation", "definition": "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell. [PMID:30010832]"}
{"concept_id": "C1155887", "aliases": ["regulation of ovarian cumulus cell differentiation"], "types": ["T043"], "canonical_name": "regulation of cumulus cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155888", "aliases": ["down-regulation of cumulus cell differentiation", "negative regulation of ovarian cumulus cell differentiation", "downregulation of cumulus cell differentiation", "down regulation of cumulus cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of cumulus cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155889", "aliases": ["up-regulation of cumulus cell differentiation", "positive regulation of ovarian cumulus cell differentiation", "up regulation of cumulus cell differentiation", "upregulation of cumulus cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of cumulus cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1155890", "aliases": [], "types": ["T042"], "canonical_name": "ovarian cumulus expansion", "definition": "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells. [PMID:30010832]"}
{"concept_id": "C1155891", "aliases": ["ovarian follicle antrum/follicular fluid biosynthesis", "ovarian follicle antrum/follicular fluid formation"], "types": ["T042"], "canonical_name": "follicular fluid formation in ovarian follicle antrum", "definition": "The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis. [GOC:dph, GOC:tb, https://www.ncbi.nlm.nih.gov/books/NBK279054/]"}
{"concept_id": "C1155893", "aliases": ["polar cell growth", "cell growth along one axis", "polarized cell growth", "cell morphogenesis by unidimensional growth", "cell growth in one dimension"], "types": ["T043"], "canonical_name": "unidimensional cell growth", "definition": "The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell. [ISBN:0943088399]"}
{"concept_id": "C1155894", "aliases": [], "types": ["T043"], "canonical_name": "dorsal closure, elongation of leading edge cells", "definition": "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis. [PMID:12147138]"}
{"concept_id": "C1155895", "aliases": ["cell wall modification during cell expansion"], "types": ["T043"], "canonical_name": "cell wall modification involved in multidimensional cell growth", "definition": "The series of events resulting in chemical or structural changes to existing cell walls and contribute to multidimensional cell growth. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C1155896", "aliases": [], "types": ["T043"], "canonical_name": "cellulose and pectin-containing cell wall modification during multidimensional cell growth"}
{"concept_id": "C1155897", "aliases": [], "types": ["T042"], "canonical_name": "initiation of primordial ovarian follicle growth", "definition": "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle). [https://www.ncbi.nlm.nih.gov/books/NBK279054/]"}
{"concept_id": "C1155898", "aliases": ["sensing of nuclear:cytoplasmic ratio", "interpretation of nuclear:cytoplasmic ratio"], "types": ["T043"], "canonical_name": "detection of nuclear:cytoplasmic ratio", "definition": "The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell. [GOC:jl]"}
{"concept_id": "C1155899", "aliases": ["metabolism resulting in cell growth"], "types": ["T043"], "canonical_name": "metabolism resulting in cell growth"}
{"concept_id": "C1155900", "aliases": [], "types": ["T043"], "canonical_name": "oocyte growth", "definition": "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]"}
{"concept_id": "C1155901", "aliases": [], "types": ["T042"], "canonical_name": "preantral ovarian follicle growth", "definition": "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]"}
{"concept_id": "C1155902", "aliases": [], "types": ["T042"], "canonical_name": "primary ovarian follicle growth", "definition": "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle). [GOC:mtg_mpo, https://www.ncbi.nlm.nih.gov/books/NBK279054/]"}
{"concept_id": "C1155904", "aliases": ["downregulation of cell growth", "down regulation of cell growth", "down-regulation of cell growth"], "types": ["T043"], "canonical_name": "negative regulation of cell growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. [GOC:go_curators]"}
{"concept_id": "C1155905", "aliases": ["up-regulation of cell growth", "up regulation of cell growth", "upregulation of cell growth"], "types": ["T043"], "canonical_name": "positive regulation of cell growth", "definition": "Any process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]"}
{"concept_id": "C1155906", "aliases": ["amoeboidal cell migration", "ameboid cell migration", "amoeboid cell migration"], "types": ["T043"], "canonical_name": "ameboidal-type cell migration", "definition": "Cell migration that is accomplished by extension and retraction of a pseudopodium. [GOC:dph]"}
{"concept_id": "C1155908", "aliases": ["follicle cell migration"], "types": ["T043"], "canonical_name": "ovarian follicle cell migration", "definition": "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:10822261]"}
{"concept_id": "C1155910", "aliases": ["germ-cell migration"], "types": ["T043"], "canonical_name": "germ cell migration", "definition": "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. [GOC:bf, GOC:jl]"}
{"concept_id": "C1155911", "aliases": ["glia cell migration"], "types": ["T043"], "canonical_name": "glial cell migration", "definition": "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1155912", "aliases": [], "types": ["T043"], "canonical_name": "inductive cell migration", "definition": "Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans. [ISBN:087969307X, ISBN:0879694882]"}
{"concept_id": "C1155913", "aliases": ["mesoderm cell migration"], "types": ["T042"], "canonical_name": "mesodermal cell migration", "definition": "The orderly movement of mesodermal cells from one site to another. [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047]"}
{"concept_id": "C1155914", "aliases": [], "types": ["T043"], "canonical_name": "pole cell migration", "definition": "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form. [GOC:bf, PMID:9988212]"}
{"concept_id": "C1155915", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell migration", "definition": "Any process that modulates the frequency, rate or extent of cell migration. [GOC:go_curators]"}
{"concept_id": "C1155916", "aliases": ["downregulation of cell migration", "down-regulation of cell migration", "down regulation of cell migration"], "types": ["T043"], "canonical_name": "negative regulation of cell migration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]"}
{"concept_id": "C1155917", "aliases": ["upregulation of cell migration", "up regulation of cell migration", "up-regulation of cell migration"], "types": ["T043"], "canonical_name": "positive regulation of cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]"}
{"concept_id": "C1155918", "aliases": ["substrate-bound cell migration"], "types": ["T043"], "canonical_name": "substrate-dependent cell migration", "definition": "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. [ISBN:0815316194, PMID:11944043, PMID:14657486]"}
{"concept_id": "C1155919", "aliases": [], "types": ["T043"], "canonical_name": "substrate-bound cell migration, adhesion receptor recycling", "definition": "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions. [PMID:11944043]"}
{"concept_id": "C1155920", "aliases": ["substrate-bound cell migration, cell attachment to substrate"], "types": ["T043"], "canonical_name": "substrate-dependent cell migration, cell attachment to substrate", "definition": "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions. [ISBN:0815316194, PMID:11944043, PMID:14657486]"}
{"concept_id": "C1155921", "aliases": ["substrate-bound cell migration, cell contraction"], "types": ["T043"], "canonical_name": "substrate-dependent cell migration, cell contraction", "definition": "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves. [ISBN:0815316194, PMID:11944043, PMID:14657486]"}
{"concept_id": "C1155922", "aliases": ["substrate-bound cell migration, cell extension"], "types": ["T043"], "canonical_name": "substrate-dependent cell migration, cell extension", "definition": "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. [ISBN:0815316194, PMID:11944043, PMID:14657486]"}
{"concept_id": "C1155923", "aliases": ["substrate-bound cell migration, cell release from substrate"], "types": ["T043"], "canonical_name": "negative regulation of cell adhesion involved in substrate-bound cell migration", "definition": "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction. [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486]"}
{"concept_id": "C1155925", "aliases": ["ciliary/flagellar motility"], "types": ["T043"], "canonical_name": "cilium or flagellum-dependent cell motility", "definition": "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. [GOC:cilia, GOC:hjd, GOC:krc]"}
{"concept_id": "C1155926", "aliases": [], "types": ["T043"], "canonical_name": "muscle filament sliding", "definition": "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. [GOC:mah, GOC:mtg_muscle, ISBN:0815316194]"}
{"concept_id": "C1155927", "aliases": [], "types": ["T042"], "canonical_name": "regulation of muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of muscle contraction. [GOC:go_curators]"}
{"concept_id": "C1155928", "aliases": ["downregulation of muscle contraction", "down-regulation of muscle contraction", "down regulation of muscle contraction"], "types": ["T040"], "canonical_name": "negative regulation of muscle contraction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. [GOC:go_curators]"}
{"concept_id": "C1155929", "aliases": ["down-regulation of smooth muscle contraction", "downregulation of smooth muscle contraction", "down regulation of smooth muscle contraction"], "types": ["T040"], "canonical_name": "negative regulation of smooth muscle contraction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators]"}
{"concept_id": "C1155930", "aliases": ["down regulation of striated muscle contraction", "down-regulation of striated muscle contraction", "downregulation of striated muscle contraction"], "types": ["T040"], "canonical_name": "negative regulation of striated muscle contraction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]"}
{"concept_id": "C1155931", "aliases": ["upregulation of muscle contraction", "up regulation of muscle contraction", "up-regulation of muscle contraction"], "types": ["T040"], "canonical_name": "positive regulation of muscle contraction", "definition": "Any process that activates or increases the frequency, rate or extent of muscle contraction. [GOC:go_curators]"}
{"concept_id": "C1155932", "aliases": ["up-regulation of smooth muscle contraction", "up regulation of smooth muscle contraction", "upregulation of smooth muscle contraction"], "types": ["T040"], "canonical_name": "positive regulation of smooth muscle contraction", "definition": "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators]"}
{"concept_id": "C1155933", "aliases": ["up-regulation of striated muscle contraction", "up regulation of striated muscle contraction", "upregulation of striated muscle contraction"], "types": ["T040"], "canonical_name": "positive regulation of striated muscle contraction", "definition": "Any process that activates or increases the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]"}
{"concept_id": "C1155934", "aliases": [], "types": ["T042"], "canonical_name": "regulation of smooth muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators]"}
{"concept_id": "C1155935", "aliases": [], "types": ["T042"], "canonical_name": "regulation of striated muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]"}
{"concept_id": "C1155937", "aliases": ["visceral muscle contraction"], "types": ["T042"], "canonical_name": "smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]"}
{"concept_id": "C1155938", "aliases": ["sarcomeric muscle contraction"], "types": ["T042"], "canonical_name": "striated muscle contraction", "definition": "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. [GOC:jl, GOC:mtg_muscle, ISBN:0198506732]"}
{"concept_id": "C1155939", "aliases": ["cellular component organization at cellular level", "cell organisation", "cellular component organisation in other organism", "cell organization and biogenesis", "cellular component organization in other organism", "cellular component organisation at cellular level"], "types": ["T043"], "canonical_name": "cellular component organization", "definition": "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:ai, GOC:jl, GOC:mah]"}
{"concept_id": "C1155940", "aliases": ["cell projection organisation", "cell projection organization and biogenesis"], "types": ["T043"], "canonical_name": "cell projection organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]"}
{"concept_id": "C1155942", "aliases": ["pilus biogenesis", "pilus formation"], "types": ["T043"], "canonical_name": "pilus assembly", "definition": "The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. [GOC:dgh, GOC:mcc2, GOC:tb]"}
{"concept_id": "C1155944", "aliases": ["IFT", "intraflagellar transport involved in microtubule-based flagellum organisation", "intraflagellar transport", "intraflagellar transport involved in cilium organization"], "types": ["T043"], "canonical_name": "intraciliary transport", "definition": "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]"}
{"concept_id": "C1155947", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of flagellum biogenesis"}
{"concept_id": "C1155948", "aliases": ["cell projection biogenesis", "formation of a cell surface projection"], "types": ["T043"], "canonical_name": "cell projection assembly", "definition": "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]"}
{"concept_id": "C1155949", "aliases": ["lamellipodium biogenesis", "lamellipodium formation", "lamellipodium biosynthesis"], "types": ["T043"], "canonical_name": "lamellipodium assembly", "definition": "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1155950", "aliases": ["microspike biosynthesis", "microspike formation", "microspike biogenesis"], "types": ["T043"], "canonical_name": "microspike assembly", "definition": "Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell. [ISBN:0815316194, PMID:11429692, PMID:12153987, PMID:19095735]"}
{"concept_id": "C1155951", "aliases": [], "types": ["T043"], "canonical_name": "microvillus biogenesis"}
{"concept_id": "C1155952", "aliases": [], "types": ["T043"], "canonical_name": "microvillar actin bundle assembly", "definition": "Assembly of the parallel bundle of actin filaments at the core of a microvillus. [GOC:mah]"}
{"concept_id": "C1155953", "aliases": ["cytoplasm organisation", "cytoplasm organization and biogenesis"], "types": ["T043"], "canonical_name": "cytoplasm organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [GOC:curators, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1155954", "aliases": [], "types": ["T043"], "canonical_name": "cell-substrate junction assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. [GOC:mah]"}
{"concept_id": "C1155957", "aliases": ["intercellular junction assembly"], "types": ["T043"], "canonical_name": "cell-cell junction assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a junction between cells. [GOC:ai]"}
{"concept_id": "C1155958", "aliases": [], "types": ["T043"], "canonical_name": "gap junction assembly", "definition": "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids. [GOC:jid, ISBN:0716731363]"}
{"concept_id": "C1155959", "aliases": [], "types": ["T043"], "canonical_name": "septate junction assembly", "definition": "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space. [GOC:ai, PMID:5272312]"}
{"concept_id": "C1155960", "aliases": [], "types": ["T043"], "canonical_name": "zonula adherens assembly", "definition": "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. [GOC:bf]"}
{"concept_id": "C1155961", "aliases": ["intercellular junction maintenance"], "types": ["T043"], "canonical_name": "cell-cell junction maintenance", "definition": "The maintenance of junctions between cells. [GOC:ai]"}
{"concept_id": "C1155962", "aliases": [], "types": ["T043"], "canonical_name": "zonula adherens maintenance", "definition": "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells. [GOC:bf]"}
{"concept_id": "C1155963", "aliases": ["organelle organization and biogenesis", "organelle organisation"], "types": ["T043"], "canonical_name": "organelle organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:mah]"}
{"concept_id": "C1155964", "aliases": ["cytoskeletal organization and biogenesis", "cytoskeleton organisation", "cytoskeleton organization and biogenesis"], "types": ["T043"], "canonical_name": "cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1155965", "aliases": [], "types": ["T043"], "canonical_name": "microfilament-based process"}
{"concept_id": "C1155966", "aliases": ["actin cytoskeleton organisation", "actin cytoskeleton organization and biogenesis"], "types": ["T043"], "canonical_name": "actin cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1155967", "aliases": [], "types": ["T043"], "canonical_name": "actin cortical patch assembly", "definition": "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells. [GOC:mah]"}
{"concept_id": "C1155968", "aliases": ["actin filament organisation"], "types": ["T043"], "canonical_name": "actin filament organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. [GOC:mah]"}
{"concept_id": "C1155970", "aliases": [], "types": ["T043"], "canonical_name": "contractile actin filament bundle assembly", "definition": "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1155971", "aliases": [], "types": ["T042"], "canonical_name": "muscle thin filament assembly", "definition": "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle. [GOC:mah]"}
{"concept_id": "C1155972", "aliases": [], "types": ["T043"], "canonical_name": "parallel actin filament bundle assembly", "definition": "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1155973", "aliases": [], "types": ["T043"], "canonical_name": "ring canal formation, actin assembly"}
{"concept_id": "C1155974", "aliases": [], "types": ["T043"], "canonical_name": "actin modification", "definition": "Covalent modification of an actin molecule. [GOC:mah]"}
{"concept_id": "C1155975", "aliases": [], "types": ["T044"], "canonical_name": "indirect flight muscle actin ubiquitination"}
{"concept_id": "C1155976", "aliases": ["actin filament nucleation"], "types": ["T044"], "canonical_name": "actin nucleation", "definition": "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. [ISBN:0815316194]"}
{"concept_id": "C1155977", "aliases": [], "types": ["T043"], "canonical_name": "actin filament-based movement", "definition": "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. [GOC:BHF, GOC:mah]"}
{"concept_id": "C1155978", "aliases": [], "types": ["T043"], "canonical_name": "vesicle transport along actin filament", "definition": "Movement of a vesicle along an actin filament, mediated by motor proteins. [GOC:mah]"}
{"concept_id": "C1155979", "aliases": [], "types": ["T043"], "canonical_name": "actin polymerization or depolymerization", "definition": "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. [GOC:mah]"}
{"concept_id": "C1155980", "aliases": ["actin depolymerizing activity", "actin filament depolymerization"], "types": ["T043"], "definition": "Disassembly of actin filaments by the removal of actin monomers from a filament. [GOC:mah]", "canonical_name": "actin depolymerization"}
{"concept_id": "C1155981", "aliases": [], "types": ["T043"], "canonical_name": "actin filament fragmentation", "definition": "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1155982", "aliases": ["actin polymerization", "actin polymerizing activity"], "types": ["T043"], "canonical_name": "actin filament polymerization", "definition": "Assembly of actin filaments by the addition of actin monomers to a filament. [GOC:mah]"}
{"concept_id": "C1155983", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin polymerization or depolymerization", "definition": "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. [GOC:mah]"}
{"concept_id": "C1155986", "aliases": ["negative regulation of actin polymerization and/or depolymerization"], "types": ["T043"], "canonical_name": "negative regulation of actin polymerization and/or depolymerization", "definition": "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization and/or depolymerization. [GOC:go_curators]"}
{"concept_id": "C1155987", "aliases": ["positive regulation of actin polymerization and/or depolymerization"], "types": ["T044"], "canonical_name": "positive regulation of actin polymerization and/or depolymerization", "definition": "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization. [GOC:go_curators]"}
{"concept_id": "C1155989", "aliases": ["establishment and/or maintenance of cell polarity", "establishment and/or maintenance of cell polarization"], "types": ["T043"], "canonical_name": "establishment or maintenance of cell polarity", "definition": "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. [GOC:mah]"}
{"concept_id": "C1155999", "aliases": ["establishment and/or maintenance of neuroblast cell polarity"], "types": ["T043"], "canonical_name": "establishment or maintenance of neuroblast polarity", "definition": "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083]"}
{"concept_id": "C1156000", "aliases": ["establishment of neuroblast cell polarity"], "types": ["T043"], "canonical_name": "establishment of neuroblast polarity", "definition": "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1156001", "aliases": ["maintenance of neuroblast cell polarity"], "types": ["T043"], "canonical_name": "maintenance of neuroblast polarity", "definition": "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1156002", "aliases": ["cell polarization"], "types": ["T043"], "canonical_name": "establishment of cell polarity", "definition": "The specification and formation of anisotropic intracellular organization or cell growth patterns. [GOC:mah]"}
{"concept_id": "C1156004", "aliases": [], "types": ["T040"], "canonical_name": "equator specification", "definition": "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves. [GOC:bf]"}
{"concept_id": "C1156005", "aliases": [], "types": ["T042"], "canonical_name": "ommatidial rotation", "definition": "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification. [PMID:10725247]"}
{"concept_id": "C1156006", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of cell polarity", "definition": "The maintenance of established anisotropic intracellular organization or cell growth patterns. [GOC:mah]"}
{"concept_id": "C1156007", "aliases": [], "types": ["T043"], "canonical_name": "establishment of tissue polarity", "definition": "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. [GOC:jid]"}
{"concept_id": "C1156008", "aliases": [], "types": ["T043"], "canonical_name": "intermediate filament-based process", "definition": "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. [GOC:ai]"}
{"concept_id": "C1156009", "aliases": ["intermediate filament cytoskeleton organization and biogenesis", "intermediate filament cytoskeleton organisation"], "types": ["T043"], "canonical_name": "intermediate filament cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins. [GOC:ai]"}
{"concept_id": "C1156010", "aliases": ["intermediate filament organisation"], "types": ["T043"], "canonical_name": "intermediate filament organization", "definition": "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. [GOC:ai]"}
{"concept_id": "C1156011", "aliases": ["tonofilament assembly"], "types": ["T043"], "canonical_name": "intermediate filament bundle assembly", "definition": "The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs. [ISBN:0716731363]"}
{"concept_id": "C1156012", "aliases": [], "types": ["T043"], "canonical_name": "intermediate filament polymerization or depolymerization", "definition": "Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament. [GOC:ai]"}
{"concept_id": "C1156013", "aliases": [], "types": ["T043"], "canonical_name": "intermediate filament depolymerization", "definition": "Disassembly of intermediate filaments by the removal of component monomers from a filament. [GOC:mah, ISBN:0716731363]"}
{"concept_id": "C1156014", "aliases": [], "types": ["T043"], "canonical_name": "intermediate filament polymerization", "definition": "Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain. [GOC:mah, PMID:8776884]"}
{"concept_id": "C1156015", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intermediate filament polymerization or depolymerization", "definition": "Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases. [ISBN:0716731363]"}
{"concept_id": "C1156016", "aliases": ["negative regulation of intermediate filament polymerization and/or depolymerization"], "types": ["T043"], "canonical_name": "negative regulation of intermediate filament polymerization and/or depolymerization", "definition": "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization. [GOC:go_curators]"}
{"concept_id": "C1156017", "aliases": ["positive regulation of intermediate filament polymerization and/or depolymerization"], "types": ["T043"], "canonical_name": "positive regulation of intermediate filament polymerization and/or depolymerization", "definition": "OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization. [GOC:go_curators]"}
{"concept_id": "C1156018", "aliases": [], "types": ["T043"], "canonical_name": "microtubule-based process", "definition": "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. [GOC:mah]"}
{"concept_id": "C1156019", "aliases": ["microtubule cytoskeleton organisation", "microtubule cytoskeleton organization and biogenesis", "microtubule dynamics"], "types": ["T043"], "canonical_name": "microtubule cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah]"}
{"concept_id": "C1156020", "aliases": ["microtubule fascicle"], "types": ["T026"], "definition": "An arrangement of closely apposed microtubules running parallel to each other. [NIF_Subcellular:sao1872343973]", "canonical_name": "microtubule bundle"}
{"concept_id": "C1156021", "aliases": [], "types": ["T043"], "canonical_name": "microtubule nucleation", "definition": "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). [GOC:go_curators, ISBN:0815316194, PMID:12517712]"}
{"concept_id": "C1156022", "aliases": [], "types": ["T044"], "canonical_name": "tubulin folding"}
{"concept_id": "C1156023", "aliases": [], "types": ["T044"], "canonical_name": "alpha-tubulin folding"}
{"concept_id": "C1156024", "aliases": [], "types": ["T044"], "canonical_name": "beta-tubulin folding"}
{"concept_id": "C1156025", "aliases": [], "types": ["T044"], "canonical_name": "chaperonin-mediated tubulin folding"}
{"concept_id": "C1156026", "aliases": [], "types": ["T044"], "canonical_name": "post-chaperonin tubulin folding pathway", "definition": "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors. [PMID:10542094]"}
{"concept_id": "C1156029", "aliases": ["oocyte microtubule cytoskeleton organisation"], "types": ["T043"], "canonical_name": "oocyte microtubule cytoskeleton organization", "definition": "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11231123]"}
{"concept_id": "C1156030", "aliases": [], "types": ["T043"], "canonical_name": "oocyte microtubule cytoskeleton polarization", "definition": "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11807042]"}
{"concept_id": "C1156031", "aliases": ["microtubule shortening", "microtubule depolymerization"], "types": ["T043"], "definition": "The removal of tubulin heterodimers from one or both ends of a microtubule. [ISBN:0815316194]", "canonical_name": "microtubule disassembly"}
{"concept_id": "C1156032", "aliases": ["microtubule polymerization"], "types": ["T043"], "definition": "The addition of tubulin heterodimers to one or both ends of a microtubule. [GOC:ai, GOC:go_curators]", "canonical_name": "microtubule assembly"}
{"concept_id": "C1156033", "aliases": [], "types": ["T043"], "canonical_name": "microtubule-based movement", "definition": "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. [GOC:cjm, ISBN:0815316194]"}
{"concept_id": "C1156035", "aliases": ["anterograde axon cargo transport"], "types": ["T043"], "definition": "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. [ISBN:0815316194]", "canonical_name": "anterograde axonal transport"}
{"concept_id": "C1156036", "aliases": ["axon transport of mitochondria"], "types": ["T043"], "canonical_name": "axonal transport of mitochondrion", "definition": "The directed movement of mitochondria along microtubules in nerve cell axons. [GOC:ai]"}
{"concept_id": "C1156037", "aliases": ["retrograde axon cargo transport"], "types": ["T043"], "definition": "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons. [ISBN:0815316194]", "canonical_name": "retrograde axonal transport"}
{"concept_id": "C1156041", "aliases": ["endosome organization and biogenesis", "endosome organisation"], "types": ["T044"], "canonical_name": "endosome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156042", "aliases": [], "types": ["T043"], "canonical_name": "endosome transport"}
{"concept_id": "C1156043", "aliases": [], "types": ["T043"], "canonical_name": "early endosome to late endosome transport", "definition": "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs. [ISBN:0815316194]"}
{"concept_id": "C1156044", "aliases": [], "types": ["T043"], "canonical_name": "endosome to lysosome transport", "definition": "The directed movement of substances from endosomes to lysosomes. [GOC:ai, ISBN:0716731363]"}
{"concept_id": "C1156045", "aliases": ["trans-Golgi to endosome transport", "TGN to endosome transport", "Golgi to endosome vesicle-mediated transport"], "types": ["T043"], "canonical_name": "Golgi to endosome transport", "definition": "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. [GOC:jl, ISBN:0716731363, PMID:10873832]"}
{"concept_id": "C1156046", "aliases": [], "types": ["T043"], "canonical_name": "late endosome to vacuole transport", "definition": "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. [PMID:11872141]"}
{"concept_id": "C1156047", "aliases": ["retrograde (endosome to Golgi) transport"], "types": ["T043"], "canonical_name": "retrograde transport, endosome to Golgi", "definition": "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. [GOC:jl, PMID:10873832, PMID:16936697]"}
{"concept_id": "C1156048", "aliases": ["ER organisation", "ER organization and biogenesis", "endoplasmic reticulum organization and biogenesis", "endoplasmic reticulum organisation"], "types": ["T043"], "canonical_name": "endoplasmic reticulum organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156049", "aliases": ["protein-endoplasmic reticulum targeting", "protein-ER targeting", "protein targeting to endoplasmic reticulum"], "types": ["T043"], "canonical_name": "protein targeting to ER", "definition": "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. [ISBN:0716731363]"}
{"concept_id": "C1156050", "aliases": ["protein-endoplasmic reticulum insertion", "integral ER membrane protein positioning", "protein-ER insertion", "positioning of protein in ER membrane", "integral ER membrane protein localization", "protein insertion into endoplasmic reticulum membrane", "localization of protein in ER membrane"], "types": ["T043"], "canonical_name": "protein insertion into ER membrane", "definition": "The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. [ISBN:0716731363]"}
{"concept_id": "C1156055", "aliases": [], "types": ["T044"], "canonical_name": "protein retention in ER lumen", "definition": "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. [ISBN:0716731363, PMID:12972550]"}
{"concept_id": "C1156056", "aliases": ["fusome organisation", "fusome organization and biogenesis"], "types": ["T043"], "canonical_name": "fusome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells. [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah]"}
{"concept_id": "C1156057", "aliases": ["vesicle-fusome targeting"], "types": ["T043"], "canonical_name": "vesicle targeting to fusome", "definition": "The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome. [PMID:9046244]"}
{"concept_id": "C1156058", "aliases": ["Golgi organization and biogenesis", "Golgi organisation"], "types": ["T043"], "canonical_name": "Golgi organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156060", "aliases": ["retention of protein in Golgi", "protein-Golgi retention"], "types": ["T043"], "canonical_name": "protein retention in Golgi apparatus", "definition": "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known. [ISBN:0716731363]"}
{"concept_id": "C1156061", "aliases": ["lysosome organization and biogenesis", "lysosome organisation"], "types": ["T043"], "canonical_name": "lysosome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. [GOC:mah]"}
{"concept_id": "C1156062", "aliases": ["lysosome pH reduction"], "types": ["T043"], "canonical_name": "lysosomal lumen acidification", "definition": "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. [GOC:jid]"}
{"concept_id": "C1156063", "aliases": [], "types": ["T043"], "canonical_name": "lysosomal transport", "definition": "The directed movement of substances into, out of or within a lysosome. [GOC:ai]"}
{"concept_id": "C1156064", "aliases": ["protein-lysosome targeting"], "types": ["T044"], "canonical_name": "protein targeting to lysosome", "definition": "The process of directing proteins towards the lysosome using signals contained within the protein. [GOC:curators]"}
{"concept_id": "C1156065", "aliases": [], "types": ["T044"], "canonical_name": "N-glycan processing to lysosome", "definition": "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome. [ISBN:0879695595]"}
{"concept_id": "C1156066", "aliases": ["mitochondria organization", "mitochondrion organisation", "mitochondrion organization and biogenesis"], "types": ["T043"], "canonical_name": "mitochondrion organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]"}
{"concept_id": "C1156067", "aliases": ["mitochondrial fusion"], "types": ["T043"], "definition": "Merging of two or more mitochondria within a cell to form a single compartment. [PMID:11038192, PMID:12052774]", "canonical_name": "mitochondrion fusion"}
{"concept_id": "C1156068", "aliases": [], "types": ["T043"], "canonical_name": "Nebenkern formation"}
{"concept_id": "C1156069", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial genome maintenance", "definition": "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. [GOC:ai, GOC:vw]"}
{"concept_id": "C1156070", "aliases": ["mitochondrial membrane organization and biogenesis", "mitochondrial membrane organisation"], "types": ["T043"], "canonical_name": "mitochondrial membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156071", "aliases": ["mitochondrial inner membrane organization", "inner mitochondrial membrane organisation", "inner mitochondrial membrane organization and biogenesis"], "types": ["T043"], "canonical_name": "inner mitochondrial membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156072", "aliases": [], "types": ["T043"], "canonical_name": "cristae formation", "definition": "The assembly of cristae, the inwards folds of the inner mitochondrial membrane. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156073", "aliases": ["protein transport into mitochondrial inner membrane", "protein import into mitochondrial inner membrane", "mitochondrial inner membrane protein import"], "types": ["T043"], "canonical_name": "protein insertion into mitochondrial inner membrane", "definition": "The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane. [GOC:mcc, GOC:vw, PMID:18672008]"}
{"concept_id": "C1156074", "aliases": ["outer mitochondrial membrane organization and biogenesis", "outer mitochondrial membrane organisation"], "types": ["T043"], "canonical_name": "outer mitochondrial membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156075", "aliases": ["mitochondrial outer membrane protein import", "protein import into mitochondrial outer membrane", "protein transport into mitochondrial outer membrane"], "types": ["T043"], "canonical_name": "protein insertion into mitochondrial outer membrane", "definition": "The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes. [GOC:mcc, GOC:vw, PMID:18672008]"}
{"concept_id": "C1156076", "aliases": ["protein-mitochondrial targeting", "protein targeting to mitochondria", "mitochondrial protein import", "protein import into mitochondrion"], "types": ["T044"], "canonical_name": "protein targeting to mitochondrion", "definition": "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. [GOC:mcc, ISBN:0716731363]"}
{"concept_id": "C1156077", "aliases": ["protein transport into mitochondrial intermembrane space", "protein transport into mitochondrial IMS", "mitochondrial intermembrane space protein import", "protein import into mitochondrial IMS"], "types": ["T043"], "canonical_name": "protein import into mitochondrial intermembrane space", "definition": "The import of proteins into the space between the inner and outer mitochondrial membranes. [ISBN:0716731363]"}
{"concept_id": "C1156079", "aliases": [], "types": ["T043"], "canonical_name": "protein import into mitochondrial intermembrane space, direct"}
{"concept_id": "C1156080", "aliases": [], "types": ["T043"], "canonical_name": "protein import into mitochondrial intermembrane space, nonconservative"}
{"concept_id": "C1156081", "aliases": ["protein transport into mitochondrial matrix", "mitochondrial matrix protein import"], "types": ["T043"], "canonical_name": "protein import into mitochondrial matrix", "definition": "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. [ISBN:0716731363]"}
{"concept_id": "C1156082", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial processing"}
{"concept_id": "C1156083", "aliases": ["mitochondrial translocation"], "types": ["T044"], "canonical_name": "mitochondrial translocation", "definition": "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery. [PMID:7600576]"}
{"concept_id": "C1156084", "aliases": ["sperm mitochondria organization and biogenesis", "sperm mitochondrion organization and biogenesis", "sperm mitochondria organisation"], "types": ["T043"], "canonical_name": "sperm mitochondrion organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm. [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]"}
{"concept_id": "C1156085", "aliases": ["peroxisome organization and biogenesis", "peroxisome organisation"], "types": ["T043"], "canonical_name": "peroxisome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. [GOC:mah]"}
{"concept_id": "C1156086", "aliases": ["peroxisome degradation", "macropexophagy"], "types": ["T043"], "definition": "The selective autophagy process in which a peroxisome is degraded by macroautophagy. [GOC:autophagy, PMID:12914914, PMID:16973210]", "canonical_name": "pexophagy"}
{"concept_id": "C1156087", "aliases": ["peroxisomal membrane catabolism", "peroxisomal membrane degradation", "peroxisomal membrane breakdown"], "types": ["T043"], "canonical_name": "peroxisomal membrane disassembly", "definition": "The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation. [GOC:mah, PMID:11382760]"}
{"concept_id": "C1156089", "aliases": [], "types": ["T043"], "canonical_name": "peroxisome inheritance", "definition": "The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p. [PMID:11733545]"}
{"concept_id": "C1156090", "aliases": [], "types": ["T043"], "canonical_name": "peroxisome membrane biogenesis", "definition": "The process in which a peroxisome membrane is synthesized, aggregates, and bonds together. [GOC:mah]"}
{"concept_id": "C1156091", "aliases": ["protein docking during peroxisome matrix protein import", "protein docking during protein import into peroxisome matrix", "peroxisome matrix protein import, docking", "protein docking during protein transport into peroxisome matrix", "protein transport into peroxisome matrix, docking"], "types": ["T043"], "canonical_name": "protein import into peroxisome matrix, docking", "definition": "The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane. [PMID:11687502, PMID:11988772, PMID:14754507]"}
{"concept_id": "C1156092", "aliases": ["receptor recycling during protein import into peroxisome matrix", "protein transport into peroxisome matrix, receptor recycling", "peroxisome matrix protein import, receptor recycling", "receptor recycling during peroxisome matrix protein import", "receptor recycling during protein transport into peroxisome matrix"], "types": ["T043"], "canonical_name": "protein import into peroxisome matrix, receptor recycling", "definition": "The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol. [PMID:11687502]"}
{"concept_id": "C1156093", "aliases": ["peroxisome matrix protein import, translocation", "protein transport into peroxisome matrix, translocation", "protein translocation during protein import into peroxisome matrix", "protein translocation during protein transport into peroxisome matrix", "protein translocation during peroxisome matrix protein import"], "types": ["T043"], "canonical_name": "protein import into peroxisome matrix, translocation", "definition": "The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation. [PMID:11687502]"}
{"concept_id": "C1156094", "aliases": [], "types": ["T043"], "canonical_name": "vesicle fusion with peroxisome", "definition": "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome. [GOC:jid]"}
{"concept_id": "C1156095", "aliases": ["protein-peroxisome targeting"], "types": ["T044"], "canonical_name": "protein targeting to peroxisome", "definition": "The process of directing proteins towards the peroxisome, usually using signals contained within the protein. [GOC:ai]"}
{"concept_id": "C1156096", "aliases": ["peroxisome matrix protein import", "protein transport to peroxisome matrix"], "types": ["T043"], "canonical_name": "protein import into peroxisome matrix", "definition": "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. [ISBN:0716731363, PMID:11687502, PMID:11988772]"}
{"concept_id": "C1156097", "aliases": ["peroxisome membrane protein import", "protein transport into peroxisome membrane"], "types": ["T043"], "canonical_name": "protein import into peroxisome membrane", "definition": "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import. [ISBN:0716731363, PMID:11687502]"}
{"concept_id": "C1156098", "aliases": ["plasma membrane organisation", "plasma membrane organization and biogenesis"], "types": ["T043"], "canonical_name": "plasma membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156099", "aliases": ["integrin biosynthesis", "integrin formation", "integrin anabolism", "integrin synthesis"], "types": ["T044"], "canonical_name": "integrin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156100", "aliases": ["beta 2 integrin biosynthesis", "beta 2 integrin synthesis", "beta 2 integrin formation", "beta 2 integrin anabolism"], "types": ["T044"], "canonical_name": "beta 2 integrin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit. [GOC:go_curators]"}
{"concept_id": "C1156101", "aliases": ["regulation of beta 2 integrin anabolism", "regulation of beta 2 integrin biosynthesis", "regulation of beta 2 integrin formation", "regulation of beta 2 integrin synthesis"], "types": ["T043"], "canonical_name": "regulation of beta 2 integrin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. [GOC:go_curators]"}
{"concept_id": "C1156102", "aliases": ["negative regulation of beta 2 integrin anabolism", "negative regulation of beta 2 integrin biosynthesis", "down-regulation of beta 2 integrin biosynthetic process", "negative regulation of beta 2 integrin synthesis", "negative regulation of beta 2 integrin formation", "downregulation of beta 2 integrin biosynthetic process", "down regulation of beta 2 integrin biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of beta 2 integrin biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. [GOC:go_curators]"}
{"concept_id": "C1156103", "aliases": ["up-regulation of beta 2 integrin biosynthetic process", "positive regulation of beta 2 integrin biosynthesis", "positive regulation of beta 2 integrin synthesis", "upregulation of beta 2 integrin biosynthetic process", "positive regulation of beta 2 integrin formation", "positive regulation of beta 2 integrin anabolism", "up regulation of beta 2 integrin biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of beta 2 integrin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. [GOC:go_curators]"}
{"concept_id": "C1156104", "aliases": ["regulation of integrin formation", "regulation of integrin synthesis", "regulation of integrin anabolism", "regulation of integrin biosynthesis"], "types": ["T043"], "canonical_name": "regulation of integrin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. [GOC:go_curators]"}
{"concept_id": "C1156105", "aliases": ["negative regulation of integrin formation", "negative regulation of integrin anabolism", "negative regulation of integrin synthesis", "down regulation of integrin biosynthetic process", "down-regulation of integrin biosynthetic process", "negative regulation of integrin biosynthesis", "downregulation of integrin biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of integrin biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. [GOC:go_curators]"}
{"concept_id": "C1156106", "aliases": ["positive regulation of integrin anabolism", "up regulation of integrin biosynthetic process", "up-regulation of integrin biosynthetic process", "positive regulation of integrin synthesis", "positive regulation of integrin biosynthesis", "positive regulation of integrin formation", "upregulation of integrin biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of integrin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. [GOC:go_curators]"}
{"concept_id": "C1156107", "aliases": ["PL scrambling", "phospholipid scrambling"], "types": ["T043"], "canonical_name": "plasma membrane phospholipid scrambling", "definition": "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions. [OMIM:604170]"}
{"concept_id": "C1156108", "aliases": [], "types": ["T043"], "canonical_name": "phospholipid translocation", "definition": "The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]"}
{"concept_id": "C1156109", "aliases": ["plasmodesma organization and biogenesis", "plasmodesmata organization and biogenesis", "plasmodesma organisation"], "types": ["T043"], "canonical_name": "plasmodesma organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. [GOC:mah, PMID:29880547]"}
{"concept_id": "C1156110", "aliases": ["plastid organisation", "plastid organization and biogenesis"], "types": ["T043"], "canonical_name": "plastid organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid. [GOC:mah]"}
{"concept_id": "C1156111", "aliases": ["amyloplast organization and biogenesis", "amyloplast organisation"], "types": ["T043"], "canonical_name": "amyloplast organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch. [GOC:jid]"}
{"concept_id": "C1156112", "aliases": ["chloroplast organisation", "chloroplast organization and biogenesis"], "types": ["T043"], "canonical_name": "chloroplast organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast. [GOC:jid]"}
{"concept_id": "C1156113", "aliases": ["chloroplast movement"], "types": ["T043"], "canonical_name": "chloroplast relocation", "definition": "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery. [PMID:11309623]"}
{"concept_id": "C1156114", "aliases": [], "types": ["T043"], "canonical_name": "chloroplast accumulation movement", "definition": "The relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis. [GOC:tb, PMID:11978863]"}
{"concept_id": "C1156115", "aliases": [], "types": ["T043"], "canonical_name": "chloroplast avoidance movement", "definition": "The relocation process in which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery. [GOC:tb, PMID:11978863]"}
{"concept_id": "C1156116", "aliases": ["protein-chloroplast targeting"], "types": ["T043"], "canonical_name": "protein targeting to chloroplast", "definition": "The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved. [ISBN:0716731363]"}
{"concept_id": "C1156117", "aliases": ["protein transport into chloroplast stroma", "chloroplast stroma protein import"], "types": ["T043"], "canonical_name": "protein import into chloroplast stroma", "definition": "The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import. [ISBN:0716731363]"}
{"concept_id": "C1156118", "aliases": ["chloroplast thylakoid membrane protein import", "protein transport into chloroplast thylakoid membrane"], "types": ["T043"], "canonical_name": "protein import into chloroplast thylakoid membrane", "definition": "The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma. [ISBN:0716731363]"}
{"concept_id": "C1156119", "aliases": ["chromoplast organisation", "chromoplast organization and biogenesis"], "types": ["T043"], "canonical_name": "chromoplast organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments. [GOC:jid]"}
{"concept_id": "C1156120", "aliases": ["etioplast organization and biogenesis", "etioplast organisation"], "types": ["T043"], "canonical_name": "etioplast organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions. [GOC:jid]"}
{"concept_id": "C1156121", "aliases": ["leucoplast organisation", "leucoplast organization and biogenesis"], "types": ["T043"], "canonical_name": "leucoplast organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes. [GOC:jid]"}
{"concept_id": "C1156122", "aliases": [], "types": ["T043"], "canonical_name": "plastid inheritance", "definition": "The partitioning of plastids between daughter cells at cell division. [GOC:mah]"}
{"concept_id": "C1156123", "aliases": ["plastid membrane organization and biogenesis", "plastid membrane organisation"], "types": ["T026"], "canonical_name": "plastid membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156124", "aliases": ["plastid inner membrane organization and biogenesis", "plastid inner membrane organisation"], "types": ["T026"], "canonical_name": "plastid inner membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156125", "aliases": ["plastid outer membrane organization and biogenesis", "plastid outer membrane organisation"], "types": ["T043"], "canonical_name": "plastid outer membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156126", "aliases": ["vacuole organization and biogenesis", "vacuolar assembly", "vacuole organisation", "vacuole biogenesis"], "types": ["T043"], "canonical_name": "vacuole organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. [GOC:mah]"}
{"concept_id": "C1156129", "aliases": [], "types": ["T043"], "canonical_name": "vacuolar transport", "definition": "The directed movement of substances into, out of or within a vacuole. [GOC:ai]"}
{"concept_id": "C1156130", "aliases": ["delivery of endocytosed proteins to the vacuole"], "types": ["T043"], "canonical_name": "endocytosed protein transport to vacuole", "definition": "The directed movement of proteins imported into a cell by endocytosis to the vacuole. [GOC:ai]"}
{"concept_id": "C1156131", "aliases": ["retrograde transport from the vacuole"], "types": ["T043"], "canonical_name": "retrograde transport, vacuole to Golgi", "definition": "The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment. [PMID:9700156]"}
{"concept_id": "C1156132", "aliases": [], "types": ["T043"], "canonical_name": "vacuolar acidification", "definition": "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. [GOC:jid]"}
{"concept_id": "C1156134", "aliases": ["vacuolar protein degradation", "vacuolar protein breakdown", "vacuolar protein catabolism"], "types": ["T040"], "canonical_name": "vacuolar protein catabolic process"}
{"concept_id": "C1156135", "aliases": ["homotypic vacuole fusion (non-autophagic)", "homotypic vacuole fusion, non-autophagic", "vacuole fusion (non-autophagic)", "homotypic vacuole fusion"], "types": ["T043"], "canonical_name": "vacuole fusion, non-autophagic", "definition": "The fusion of two vacuole membranes to form a single vacuole. [GOC:jl]"}
{"concept_id": "C1156136", "aliases": ["heterotypic vacuole fusion (non-autophagic)"], "types": ["T043"], "canonical_name": "heterotypic vacuole fusion, non-autophagic"}
{"concept_id": "C1156138", "aliases": [], "types": ["T043"], "canonical_name": "vacuole inheritance", "definition": "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. [GOC:mcc, PMID:10873824, PMID:14616069]"}
{"concept_id": "C1156139", "aliases": ["vesicle organisation", "vesicle organization and biogenesis"], "types": ["T043"], "canonical_name": "vesicle organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. [GOC:mah]"}
{"concept_id": "C1156140", "aliases": ["ribosome biogenesis and assembly"], "types": ["T043"], "canonical_name": "ribosome biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]"}
{"concept_id": "C1156141", "aliases": [], "types": ["T043"], "canonical_name": "ribosome assembly", "definition": "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. [GOC:ma]"}
{"concept_id": "C1156142", "aliases": [], "types": ["T043"], "canonical_name": "mature ribosome assembly", "definition": "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome. [GOC:ma]"}
{"concept_id": "C1156143", "aliases": [], "types": ["T043"], "canonical_name": "ribosomal subunit assembly"}
{"concept_id": "C1156149", "aliases": [], "types": ["T043"], "canonical_name": "ribosome export from nucleus"}
{"concept_id": "C1156150", "aliases": ["ribosomal large subunit export from cell nucleus", "ribosomal large subunit export out of nucleus", "ribosomal large subunit transport from nucleus to cytoplasm", "ribosomal large subunit-nucleus export"], "types": ["T043"], "canonical_name": "ribosomal large subunit export from nucleus", "definition": "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. [GOC:mah]"}
{"concept_id": "C1156151", "aliases": ["ribosomal small subunit export from cell nucleus", "ribosomal small subunit export out of nucleus", "ribosomal small subunit-nucleus export", "ribosomal small subunit transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "ribosomal small subunit export from nucleus", "definition": "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm. [GOC:mah]"}
{"concept_id": "C1156152", "aliases": [], "types": ["T045"], "canonical_name": "rRNA processing", "definition": "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. [GOC:curators]"}
{"concept_id": "C1156153", "aliases": [], "types": ["T045"], "canonical_name": "35S primary transcript processing"}
{"concept_id": "C1156154", "aliases": [], "types": ["T045"], "canonical_name": "processing of 20S pre-rRNA"}
{"concept_id": "C1156156", "aliases": ["external encapsulating structure organization and biogenesis", "external encapsulating structure organisation"], "types": ["T043"], "canonical_name": "external encapsulating structure organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156157", "aliases": ["capsule organisation", "capsule organization and biogenesis"], "types": ["T043"], "canonical_name": "capsule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi. [GOC:ai]"}
{"concept_id": "C1156158", "aliases": ["capsule polysaccharide synthesis", "capsule polysaccharide anabolism", "capsule polysaccharide biosynthesis", "capsular polysaccharide biosynthetic process", "capsule polysaccharide formation", "capsular polysaccharide biosynthesis"], "types": ["T044"], "canonical_name": "capsule polysaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi. [GOC:go_curators]"}
{"concept_id": "C1156159", "aliases": ["cell wall organization and biogenesis"], "types": ["T043"], "canonical_name": "cell wall organization and biogenesis"}
{"concept_id": "C1156160", "aliases": [], "types": ["T043"], "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. [GOC:jl, GOC:mah, GOC:mtg_sensu, ISBN:0198506732]", "canonical_name": "cell wall biogenesis"}
{"concept_id": "C1156161", "aliases": [], "types": ["T043"], "canonical_name": "peptidoglycan-based cell wall biogenesis", "definition": "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. [GOC:go_curators]"}
{"concept_id": "C1156162", "aliases": ["peptidoglycan anabolism", "peptidoglycan synthesis", "murein biosynthetic process", "peptidoglycan biosynthesis", "murein biosynthesis", "peptidoglycan formation"], "types": ["T044"], "canonical_name": "peptidoglycan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]"}
{"concept_id": "C1156163", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan-protein cross-linking", "definition": "The process of covalently linking peptidoglycan (murein) to proteins. [GOC:jsg]"}
{"concept_id": "C1156164", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine", "definition": "The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan. [RESID:AA0218]"}
{"concept_id": "C1156165", "aliases": ["teichoic acid biosynthesis", "teichoic acid anabolism", "teichoic acid synthesis", "teichoic acid formation"], "types": ["T044"], "canonical_name": "teichoic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. [ISBN:0198506732]"}
{"concept_id": "C1156166", "aliases": ["fungal-type cell wall anabolism", "fungal-type cell wall synthesis", "fungal-type cell wall assembly", "fungal-type cell wall biosynthetic process", "fungal-type cell wall formation"], "types": ["T043"], "canonical_name": "fungal-type cell wall biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1156167", "aliases": ["cell wall chitin biosynthesis", "cell wall chitin anabolism", "cell wall chitin formation", "cell wall chitin synthesis"], "types": ["T044"], "canonical_name": "cell wall chitin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. [GOC:ai]"}
{"concept_id": "C1156168", "aliases": ["cellulose and pectin-containing cell wall biogenesis"], "types": ["T043"], "canonical_name": "plant-type cell wall biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana. [GOC:go_curators, GOC:lr, GOC:mtg_sensu]"}
{"concept_id": "C1156169", "aliases": ["cellulose and pectin-containing primary cell wall biogenesis", "primary cell wall synthesis", "primary cell wall anabolism", "primary cell wall formation", "primary cell wall biogenesis", "primary cell wall biosynthetic process"], "types": ["T043"], "canonical_name": "plant-type primary cell wall biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana. [GOC:lr, GOC:mtg_sensu]"}
{"concept_id": "C1156170", "aliases": ["cellulose and pectin-containing secondary cell wall biogenesis", "secondary cell wall biosynthetic process", "secondary cell wall formation", "secondary cell wall anabolism", "secondary cell wall synthesis", "secondary cell wall biogenesis"], "types": ["T043"], "canonical_name": "plant-type secondary cell wall biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana. [GOC:lr, GOC:mtg_sensu]"}
{"concept_id": "C1156171", "aliases": ["cell wall mannoprotein biosynthesis", "cell wall mannoprotein synthesis", "cell wall mannoprotein formation", "cell wall mannoprotein anabolism"], "types": ["T044"], "canonical_name": "cell wall mannoprotein biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues. [GOC:ai]"}
{"concept_id": "C1156172", "aliases": [], "types": ["T043"], "canonical_name": "cell wall modification", "definition": "The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. [GOC:jl]"}
{"concept_id": "C1156173", "aliases": ["cellulose and pectin-containing cell wall modification"], "types": ["T043"], "canonical_name": "plant-type cell wall modification", "definition": "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana. [GOC:lr, GOC:mtg_sensu]"}
{"concept_id": "C1156174", "aliases": ["cellulose and pectin-containing cell wall loosening"], "types": ["T043"], "canonical_name": "plant-type cell wall loosening", "definition": "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana. [GOC:lr, GOC:mtg_sensu]"}
{"concept_id": "C1156175", "aliases": [], "types": ["T043"], "canonical_name": "cell wall modification during abscission"}
{"concept_id": "C1156176", "aliases": [], "types": ["T043"], "canonical_name": "cell wall modification during ripening"}
{"concept_id": "C1156177", "aliases": ["plant-type cell wall organization and biogenesis", "cellulose and pectin-containing cell wall organization and biogenesis", "plant-type cell wall organization or biogenesis", "plant-type cell wall organisation", "plant-type cell wall organisation or biogenesis"], "types": ["T043"], "definition": "A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. [GOC:jid, GOC:mtg_sensu]", "canonical_name": "plant-type cell wall organization"}
{"concept_id": "C1156178", "aliases": ["S-layer organisation", "S-layer organization and biogenesis"], "types": ["T043"], "canonical_name": "S-layer organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria. [GOC:ai]"}
{"concept_id": "C1156179", "aliases": ["slime layer organization and biogenesis", "slime layer organisation"], "types": ["T043"], "canonical_name": "slime layer organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. [GOC:ai]"}
{"concept_id": "C1156180", "aliases": ["slime layer polysaccharide synthesis", "slime layer polysaccharide anabolism", "slime layer polysaccharide formation", "slime layer polysaccharide biosynthesis"], "types": ["T043"], "canonical_name": "slime layer polysaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall. [GOC:go_curators]"}
{"concept_id": "C1156182", "aliases": ["membrane degradation", "membrane breakdown", "membrane catabolism"], "types": ["T043"], "canonical_name": "membrane disassembly", "definition": "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. [GOC:mah]"}
{"concept_id": "C1156184", "aliases": [], "types": ["T043"], "canonical_name": "pronuclear envelope synthesis", "definition": "Synthesis and ordering of the envelope of pronuclei. [GOC:ems]"}
{"concept_id": "C1156185", "aliases": ["nuclear organisation", "nucleus organization and biogenesis", "nuclear organization", "nuclear organization and biogenesis"], "types": ["T043"], "canonical_name": "nucleus organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. [GOC:dph, GOC:ems, GOC:jl, GOC:mah]"}
{"concept_id": "C1156187", "aliases": ["establishment or maintenance of chromatin architecture", "chromatin organisation"], "types": ["T045"], "canonical_name": "chromatin organization", "definition": "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. [GOC:mah, GOC:vw, PMID:20404130]"}
{"concept_id": "C1156188", "aliases": ["chromatin assembly or disassembly"], "types": ["T045"], "definition": "The mechanisms effecting establishment, maintenance, and modification of that specific physical conformation of CHROMATIN determining the transcriptional accessibility or inaccessibility of the DNA.", "canonical_name": "chromatin assembly/disassembly"}
{"concept_id": "C1156189", "aliases": ["nucleosome modeling"], "types": ["T045"], "canonical_name": "nucleosome assembly", "definition": "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. [GOC:mah]"}
{"concept_id": "C1156190", "aliases": [], "types": ["T043"], "canonical_name": "DNA replication-dependent nucleosome assembly"}
{"concept_id": "C1156191", "aliases": ["transcription-coupled nucleosome assembly"], "types": ["T045"], "canonical_name": "DNA replication-independent chromatin assembly", "definition": "The formation of nucleosomes outside the context of DNA replication. [GOC:mah]"}
{"concept_id": "C1156193", "aliases": [], "types": ["T043"], "canonical_name": "nucleosome disassembly", "definition": "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. [GOC:mah]"}
{"concept_id": "C1156198", "aliases": [], "types": ["T045"], "canonical_name": "chromatin modification", "definition": "OBSOLETE. The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. [GOC:mah, GOC:vw]"}
{"concept_id": "C1156199", "aliases": [], "types": ["T044"], "definition": "The covalent alteration of one or more amino acid residues within a histone protein. [GOC:krc]", "canonical_name": "histone modification"}
{"concept_id": "C1156200", "aliases": [], "types": ["T044"], "definition": "The modification of a histone by the addition of an acetyl group. [GOC:ai]", "canonical_name": "histone acetylation"}
{"concept_id": "C1156201", "aliases": [], "types": ["T044"], "definition": "The modification of histones by removal of acetyl groups. [GOC:ai]", "canonical_name": "histone deacetylation"}
{"concept_id": "C1156202", "aliases": [], "types": ["T044"], "definition": "The modification of histones by removal of methyl groups. [GOC:ai]", "canonical_name": "histone demethylation"}
{"concept_id": "C1156204", "aliases": ["histone deubiquitylation", "histone deubiquitinylation"], "types": ["T044"], "canonical_name": "histone deubiquitination", "definition": "The modification of histones by removal of ubiquitin groups. [GOC:ai]"}
{"concept_id": "C1156205", "aliases": [], "types": ["T044"], "definition": "The modification of histones by addition of methyl groups. [GOC:ai]", "canonical_name": "histone methylation"}
{"concept_id": "C1156206", "aliases": [], "types": ["T044"], "canonical_name": "histone phosphorylation", "definition": "The modification of histones by addition of phosphate groups. [GOC:ai]"}
{"concept_id": "C1156207", "aliases": ["histone ubiquitylation", "histone ubiquitinylation"], "types": ["T044"], "canonical_name": "histone ubiquitination", "definition": "The modification of histones by addition of ubiquitin groups. [GOC:ai]"}
{"concept_id": "C1156210", "aliases": ["chromatin remodeling", "chromatin modelling", "chromatin remodelling"], "types": ["T045"], "definition": "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]", "canonical_name": "chromatin modeling"}
{"concept_id": "C1156211", "aliases": [], "types": ["T045"], "canonical_name": "chromatin insulator sequence binding", "definition": "Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription. [GOC:jl, PMID:12783795]"}
{"concept_id": "C1156213", "aliases": ["rDNA chromatin silencing", "heterochromatic silencing at rDNA", "chromatin silencing at ribosomal DNA"], "types": ["T045"], "canonical_name": "chromatin silencing at rDNA"}
{"concept_id": "C1156217", "aliases": [], "types": ["T045"], "canonical_name": "establishment of chromatin silencing"}
{"concept_id": "C1156220", "aliases": ["methylation-dependent heterochromatic silencing"], "types": ["T043"], "canonical_name": "methylation-dependent chromatin silencing"}
{"concept_id": "C1156227", "aliases": ["nuclear body organisation", "nuclear body organization and biogenesis"], "types": ["T043"], "canonical_name": "nuclear body organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1156228", "aliases": ["Cajal body organisation", "Cajal body organization and biogenesis"], "types": ["T043"], "canonical_name": "Cajal body organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors. [GOC:mah, PMID:11031238]"}
{"concept_id": "C1156229", "aliases": ["Lands organization and biogenesis", "Lands organisation", "LYSP100-associated nuclear domain organization"], "types": ["T043"], "canonical_name": "Lands organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies. [GOC:mah, PMID:10921892, PMID:8695863]"}
{"concept_id": "C1156230", "aliases": ["PML body organisation", "PML body organization and biogenesis"], "types": ["T043"], "canonical_name": "PML body organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia). [GOC:mah, PMID:10806078]"}
{"concept_id": "C1156231", "aliases": ["nuclear pore complex organization and biogenesis", "nuclear pore organization and biogenesis", "nuclear pore organisation"], "types": ["T043"], "canonical_name": "nuclear pore organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. [GOC:dph, GOC:jid, GOC:jl, GOC:mah]"}
{"concept_id": "C1156233", "aliases": ["nucleolus biogenesis", "nucleolus assembly"], "types": ["T043"], "canonical_name": "nucleologenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156234", "aliases": ["nucleolus organization and biogenesis", "nucleolus organisation"], "types": ["T043"], "canonical_name": "nucleolus organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. [GOC:dph, GOC:jid, GOC:jl, GOC:mah]"}
{"concept_id": "C1156235", "aliases": [], "types": ["T043"], "definition": "Cell Proliferation Regulation involves intercellular, cellular, and subcellular mechanisms that determine when and whether cell division occurs.", "canonical_name": "regulation of cell proliferation"}
{"concept_id": "C1156236", "aliases": ["downregulation of cell proliferation", "negative regulation of cell population proliferation", "negative regulation of cell proliferation", "inhibition of cell proliferation", "down regulation of cell proliferation"], "types": ["T043"], "definition": "Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]", "canonical_name": "down-regulation of cell proliferation"}
{"concept_id": "C1156237", "aliases": ["up-regulation of cell proliferation", "up regulation of cell proliferation", "positive regulation of cell population proliferation", "stimulation of cell proliferation", "upregulation of cell proliferation"], "types": ["T043"], "definition": "Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]", "canonical_name": "positive regulation of cell proliferation"}
{"concept_id": "C1156238", "aliases": ["cellular morphogenesis"], "types": ["T043"], "canonical_name": "cell morphogenesis", "definition": "The developmental process in which the size or shape of a cell is generated and organized. [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1156243", "aliases": [], "types": ["T043"], "canonical_name": "colony morphology", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mcc]"}
{"concept_id": "C1156244", "aliases": [], "types": ["T046"], "definition": "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. [GOC:mcc, PMID:9728395]", "canonical_name": "invasive growth"}
{"concept_id": "C1156246", "aliases": [], "types": ["T043"], "canonical_name": "filamentous growth", "definition": "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. [GOC:mcc, PMID:11729141]"}
{"concept_id": "C1156247", "aliases": ["formation of symbiont invasive hypha within host during symbiotic interaction", "formation of symbiont invasive hypha within host", "invasive hyphal growth", "symbiont invasive hypha formation within host", "formation of symbiont invasive hypha in host"], "types": ["T043"], "canonical_name": "hyphal growth", "definition": "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls. [GOC:mcc, ISBN:0471522295]"}
{"concept_id": "C1156248", "aliases": [], "types": ["T043"], "canonical_name": "pseudohyphal growth", "definition": "The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli. [GOC:krc, PMID:11104818, PMID:19347739, PMID:24710476]"}
{"concept_id": "C1156249", "aliases": [], "types": ["T043"], "definition": "Any process that modulates the surface configuration of a cell. [GOC:dph, GOC:go_curators, GOC:tb]", "canonical_name": "regulation of cell shape"}
{"concept_id": "C1156252", "aliases": [], "types": ["T043"], "canonical_name": "shape changes of embryonic cells"}
{"concept_id": "C1156253", "aliases": ["regulation of cell size"], "types": ["T043"], "definition": "Any process that modulates the size of a cell. [GOC:go_curators]", "canonical_name": "cell size control"}
{"concept_id": "C1156254", "aliases": ["downregulation of cell size", "down-regulation of cell size", "down regulation of cell size"], "types": ["T043"], "canonical_name": "negative regulation of cell size", "definition": "Any process that reduces cell size. [GOC:go_curators]"}
{"concept_id": "C1156255", "aliases": ["up-regulation of cell size", "upregulation of cell size", "up regulation of cell size"], "types": ["T043"], "canonical_name": "positive regulation of cell size", "definition": "Any process that increases cell size. [GOC:go_curators]"}
{"concept_id": "C1156256", "aliases": ["chemi-mechanical coupling"], "types": ["T043"], "canonical_name": "chemi-mechanical coupling", "definition": "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle). [GOC:jid, http://www.m-w.com]"}
{"concept_id": "C1156257", "aliases": ["cell acyl-CoA homeostasis"], "types": ["T043"], "canonical_name": "cellular acyl-CoA homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1156258", "aliases": ["cell glucose homeostasis"], "types": ["T043"], "canonical_name": "cellular glucose homeostasis", "definition": "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1156260", "aliases": [], "types": ["T039"], "canonical_name": "anion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of anions within an organism or cell. [GOC:ceb, GOC:jid, GOC:mah]"}
{"concept_id": "C1156262", "aliases": [], "types": ["T043"], "canonical_name": "cellular phosphate ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell. [GOC:mah]"}
{"concept_id": "C1156263", "aliases": ["sulphate ion homeostasis", "sulfate homeostasis"], "types": ["T043"], "canonical_name": "sulfate ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell. [GOC:jid, GOC:mah]"}
{"concept_id": "C1156264", "aliases": [], "types": ["T043"], "canonical_name": "monovalent inorganic anion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]"}
{"concept_id": "C1156265", "aliases": [], "types": ["T043"], "canonical_name": "cellular chloride ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell. [GOC:mah]"}
{"concept_id": "C1156266", "aliases": [], "types": ["T043"], "canonical_name": "cellular cation homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of cations at the level of a cell. [GOC:ceb, GOC:mah]"}
{"concept_id": "C1156268", "aliases": ["cadmium homeostasis"], "types": ["T043"], "canonical_name": "cadmium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of cadmium ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]"}
{"concept_id": "C1156269", "aliases": ["regulation of calcium ion concentration"], "types": ["T043"], "definition": "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. [GOC:ceb, GOC:jid, GOC:mah]", "canonical_name": "calcium ion homeostasis"}
{"concept_id": "C1156270", "aliases": [], "types": ["T040"], "canonical_name": "vacuolar calcium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings. [GOC:ai, GOC:mah]"}
{"concept_id": "C1156271", "aliases": [], "types": ["T043"], "canonical_name": "cobalt homeostasis"}
{"concept_id": "C1156272", "aliases": [], "types": ["T043"], "canonical_name": "copper homeostasis"}
{"concept_id": "C1156273", "aliases": ["iron ion homeostasis"], "types": ["T043"], "definition": "Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]", "canonical_name": "iron homeostasis"}
{"concept_id": "C1156274", "aliases": ["extracellular storage of iron ion", "extracellular iron ion sequestration", "extracellular iron ion sequestering", "extracellular iron ion retention", "extracellular iron ion storage", "extracellular sequestration of iron ion", "extracellular retention of iron ion"], "types": ["T040"], "canonical_name": "extracellular sequestering of iron ion", "definition": "The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system. [GOC:ai, GOC:cjm]"}
{"concept_id": "C1156275", "aliases": ["intracellular iron ion retention", "intracellular iron ion sequestering", "intracellular sequestration of iron ion", "intracellular iron ion storage", "intracellular storage of iron ion", "intracellular iron ion sequestration", "intracellular retention of iron ion"], "types": ["T043"], "canonical_name": "intracellular sequestering of iron ion", "definition": "The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system. [GOC:ai]"}
{"concept_id": "C1156276", "aliases": [], "types": ["T043"], "canonical_name": "manganese homeostasis"}
{"concept_id": "C1156277", "aliases": [], "types": ["T043"], "canonical_name": "zinc homeostasis"}
{"concept_id": "C1156278", "aliases": [], "types": ["T043"], "canonical_name": "cellular metal ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C1156279", "aliases": [], "types": ["T043"], "canonical_name": "cellular heavy metal ion homeostasis", "definition": "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. [GOC:kd, GOC:mah]"}
{"concept_id": "C1156280", "aliases": [], "types": ["T040"], "canonical_name": "potassium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. [GOC:jid, GOC:mah]"}
{"concept_id": "C1156281", "aliases": [], "types": ["T040"], "canonical_name": "sodium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]"}
{"concept_id": "C1156282", "aliases": [], "types": ["T043"], "canonical_name": "cellular monovalent inorganic cation homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C1156283", "aliases": ["regulation of cellular pH", "proton homeostasis"], "types": ["T043"], "definition": "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. [GOC:dph, GOC:mah, GOC:tb]", "canonical_name": "cellular hydrogen ion homeostasis"}
{"concept_id": "C1156284", "aliases": ["regulation of pH"], "types": ["T040"], "definition": "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. [GOC:dph, GOC:go_curators, GOC:tb]", "canonical_name": "hydrogen ion homeostasis"}
{"concept_id": "C1156287", "aliases": [], "types": ["T043"], "canonical_name": "cell redox homeostasis", "definition": "Any process that maintains the redox environment of a cell or compartment within a cell. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1156291", "aliases": ["regulation of cell volume"], "types": ["T040"], "canonical_name": "cell volume homeostasis", "definition": "Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1156292", "aliases": ["RVD"], "types": ["T043"], "definition": "Any process that decreases cell volume. [GOC:go_curators]", "canonical_name": "negative regulation of cell volume"}
{"concept_id": "C1156293", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell volume", "definition": "Any process that increases cell volume. [GOC:go_curators]"}
{"concept_id": "C1156294", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane potential", "definition": "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]"}
{"concept_id": "C1156295", "aliases": ["downregulation of membrane potential", "down regulation of membrane potential", "down-regulation of membrane potential", "reduction of membrane potential"], "types": ["T043"], "canonical_name": "negative regulation of membrane potential", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:go_curators]"}
{"concept_id": "C1156296", "aliases": ["upregulation of membrane potential", "elevation of membrane potential", "up regulation of membrane potential", "up-regulation of membrane potential"], "types": ["T043"], "canonical_name": "positive regulation of membrane potential", "definition": "Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:go_curators]"}
{"concept_id": "C1156297", "aliases": [], "types": ["T043"], "canonical_name": "stabilization of membrane potential", "definition": "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156298", "aliases": ["ER membrane fusion"], "types": ["T043"], "canonical_name": "endoplasmic reticulum membrane fusion", "definition": "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum. [GOC:elh, GOC:jid]"}
{"concept_id": "C1156299", "aliases": [], "types": ["T043"], "canonical_name": "nuclear membrane fusion", "definition": "The joining of 2 or more lipid bilayer membranes that surround the nucleus. [GOC:elh]"}
{"concept_id": "C1156300", "aliases": ["nuclear fusion", "nuclear fusion during karyogamy"], "types": ["T043"], "definition": "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. [GOC:elh]", "canonical_name": "karyogamy"}
{"concept_id": "C1156301", "aliases": [], "types": ["T043"], "canonical_name": "karyogamy during conjugation with cellular fusion"}
{"concept_id": "C1156304", "aliases": [], "types": ["T043"], "canonical_name": "nuclear exchange during conjugation without cellular fusion"}
{"concept_id": "C1156305", "aliases": [], "types": ["T043"], "canonical_name": "pronuclear fusion", "definition": "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome. [GOC:ems, ISBN:087969307X]"}
{"concept_id": "C1156307", "aliases": [], "types": ["T043"], "canonical_name": "sperm-oocyte fusion"}
{"concept_id": "C1156308", "aliases": [], "types": ["T043"], "canonical_name": "cytogamy", "definition": "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae. [GOC:elh]"}
{"concept_id": "C1156309", "aliases": [], "types": ["T043"], "definition": "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:mtg_muscle, GOC:tb]", "canonical_name": "syncytium formation by plasma membrane fusion"}
{"concept_id": "C1156310", "aliases": ["viral-induced cell-cell fusion", "viral-induced host cell-cell fusion", "induction by virus of cell-cell fusion in host"], "types": ["T043"], "canonical_name": "induction by virus of host cell-cell fusion", "definition": "The process of syncytia-forming cell-cell fusion, caused by a virus. [ISBN:0781718325]"}
{"concept_id": "C1156311", "aliases": ["viral envelope fusion with host membrane", "viral envelope fusion with host plasma membrane", "viral penetration via membrane fusion", "viral envelope fusion with host cell membrane"], "types": ["T043"], "canonical_name": "fusion of virus membrane with host plasma membrane", "definition": "Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm. [GOC:bf, GOC:jl]"}
{"concept_id": "C1156312", "aliases": ["DCP metabolic process", "DCP metabolism", "1,3-dichloro-2-propanol metabolism"], "types": ["T044"], "canonical_name": "1,3-dichloro-2-propanol metabolic process", "definition": "The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers. [GOC:jl, UM-BBD_pathwayID:dcp]"}
{"concept_id": "C1156313", "aliases": ["1,3-dichloro-2-propanol biosynthesis", "1,3-dichloro-2-propanol synthesis", "1,3-dichloro-2-propanol formation", "1,3-dichloro-2-propanol anabolism"], "types": ["T044"], "canonical_name": "1,3-dichloro-2-propanol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. [GOC:ai]"}
{"concept_id": "C1156314", "aliases": ["1,3-dichloro-2-propanol breakdown", "1,3-dichloro-2-propanol degradation", "1,3-dichloro-2-propanol catabolism"], "types": ["T044"], "canonical_name": "1,3-dichloro-2-propanol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. [GOC:ai]"}
{"concept_id": "C1156315", "aliases": ["alcohol biosynthesis", "alcohol anabolism", "alcohol formation", "alcohol synthesis"], "types": ["T044"], "canonical_name": "alcohol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. [GOC:ai]"}
{"concept_id": "C1156316", "aliases": [], "types": ["T044"], "canonical_name": "catechol-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. [GOC:go_curators]"}
{"concept_id": "C1156318", "aliases": ["methylgallate biosynthesis", "methylgallate formation", "methylgallate anabolism", "methylgallate synthesis"], "types": ["T044"], "canonical_name": "methylgallate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid. [GOC:ai]"}
{"concept_id": "C1156319", "aliases": ["protocatechuate formation", "protocatechuate biosynthetic process", "protocatechuate synthesis", "protocatechuate biosynthesis", "protocatechuate anabolism"], "types": ["T044"], "canonical_name": "3,4-dihydroxybenzoate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. [GOC:ai]"}
{"concept_id": "C1156321", "aliases": ["farnesol anabolism", "farnesol biosynthesis", "farnesol formation", "farnesol synthesis"], "types": ["T044"], "canonical_name": "farnesol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. [ISBN:0198547684]"}
{"concept_id": "C1156322", "aliases": ["glycolate biosynthesis", "glycolate synthesis", "glycolate anabolism", "glycolate formation"], "types": ["T044"], "canonical_name": "glycolate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid). [GOC:ai]"}
{"concept_id": "C1156323", "aliases": ["methanol synthesis", "methanol biosynthesis", "methanol anabolism", "methanol formation"], "types": ["T044"], "canonical_name": "methanol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. [GOC:ai]"}
{"concept_id": "C1156324", "aliases": ["monosaccharide anabolism", "monosaccharide biosynthesis", "monosaccharide synthesis", "monosaccharide formation"], "types": ["T044"], "canonical_name": "monosaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. [ISBN:0198506732]"}
{"concept_id": "C1156325", "aliases": ["hexose biosynthesis", "hexose formation", "hexose anabolism", "hexose synthesis"], "types": ["T044"], "canonical_name": "hexose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156326", "aliases": ["allose biosynthesis", "allose anabolism", "allose formation", "allose synthesis"], "types": ["T044"], "canonical_name": "allose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. [ISBN:0198506732]"}
{"concept_id": "C1156327", "aliases": ["D-allose biosynthesis", "D-allose formation", "D-allose synthesis", "D-allose anabolism"], "types": ["T044"], "canonical_name": "D-allose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1156328", "aliases": ["fructose biosynthesis", "fructose formation", "fructose synthesis", "fructose anabolism"], "types": ["T044"], "canonical_name": "fructose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose. [GOC:ai]"}
{"concept_id": "C1156329", "aliases": ["fucose formation", "fucose synthesis", "fucose biosynthesis", "fucose anabolism"], "types": ["T044"], "canonical_name": "fucose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose). [GOC:jl]"}
{"concept_id": "C1156330", "aliases": ["L-fucose formation", "L-fucose anabolism", "L-fucose biosynthesis", "L-fucose synthesis"], "types": ["T044"], "canonical_name": "L-fucose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose). [GOC:jl]"}
{"concept_id": "C1156331", "aliases": ["GDP-L-fucose formation", "GDP-L-fucose anabolism", "GDP-L-fucose biosynthesis", "GDP-L-fucose synthesis"], "types": ["T044"], "canonical_name": "GDP-L-fucose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate. [GOC:jl]"}
{"concept_id": "C1156332", "aliases": ["GDP-L-fucose biosynthesis, de novo pathway", "GDP-L-fucose biosynthetic process, de novo pathway", "'de novo' GDP-L-fucose biosynthesis", "'de novo' GDP-L-fucose synthesis", "'de novo' GDP-L-fucose anabolism", "'de novo' GDP-L-fucose formation"], "types": ["T044"], "canonical_name": "'de novo' GDP-L-fucose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271). [EC:1.1.1.271, PMID:11030750]"}
{"concept_id": "C1156333", "aliases": ["GDP-L-fucose biosynthetic process, salvage pathway", "GDP-L-fucose biosynthesis, salvage pathway"], "types": ["T044"], "canonical_name": "GDP-L-fucose salvage", "definition": "The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30). [GOC:ma]"}
{"concept_id": "C1156334", "aliases": ["galactose anabolism", "galactose formation", "galactose biosynthesis", "galactose synthesis"], "types": ["T044"], "canonical_name": "galactose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose. [ISBN:0198506732]"}
{"concept_id": "C1156335", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glucose biosynthesis"}
{"concept_id": "C1156336", "aliases": ["downregulation of gluconeogenesis", "down regulation of gluconeogenesis", "down-regulation of gluconeogenesis"], "types": ["T043"], "canonical_name": "negative regulation of gluconeogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. [GOC:go_curators]"}
{"concept_id": "C1156337", "aliases": ["upregulation of gluconeogenesis", "up regulation of gluconeogenesis", "up-regulation of gluconeogenesis"], "types": ["T043"], "definition": "Any process that activates or increases the frequency, rate or extent of gluconeogenesis. [GOC:go_curators]", "canonical_name": "positive regulation of gluconeogenesis"}
{"concept_id": "C1156338", "aliases": ["mannose anabolism", "mannose formation", "mannose synthesis", "mannose biosynthesis"], "types": ["T044"], "canonical_name": "mannose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. [GOC:ai]"}
{"concept_id": "C1156339", "aliases": ["dTDP-mannose anabolism", "dTDP-mannose synthesis", "dTDP-mannose biosynthesis", "dTDP-mannose formation"], "types": ["T044"], "canonical_name": "dTDP-mannose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate. [GOC:ai]"}
{"concept_id": "C1156340", "aliases": ["GDP-mannose formation", "GDP-mannose biosynthesis", "GDP-mannose synthesis", "GDP-mannose anabolism"], "types": ["T044"], "canonical_name": "GDP-mannose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. [GOC:ai]"}
{"concept_id": "C1156341", "aliases": ["inositol synthesis", "inositol anabolism", "inositol biosynthesis", "vitamin Bh biosynthesis", "myo-inositol biosynthetic process", "inositol formation", "vitamin Bh biosynthetic process", "myo-inositol biosynthesis"], "types": ["T044"], "canonical_name": "inositol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. [ISBN:0198547684]"}
{"concept_id": "C1156342", "aliases": ["rhamnose anabolism", "rhamnose synthesis", "rhamnose biosynthesis", "rhamnose formation"], "types": ["T044"], "canonical_name": "rhamnose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose. [ISBN:0198506732]"}
{"concept_id": "C1156343", "aliases": ["dTDP-rhamnose synthesis", "dTDP-rhamnose formation", "dTDP-rhamnose anabolism", "dTDP-rhamnose biosynthesis"], "types": ["T044"], "canonical_name": "dTDP-rhamnose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate. [GOC:ai]"}
{"concept_id": "C1156344", "aliases": ["GDP-D-rhamnose formation", "GDP-D-rhamnose synthesis", "GDP-D-rhamnose anabolism", "GDP-D-rhamnose biosynthesis"], "types": ["T044"], "canonical_name": "GDP-D-rhamnose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate. [GOC:ai]"}
{"concept_id": "C1156345", "aliases": ["pentose anabolism", "pentose biosynthesis", "pentose formation", "pentose synthesis"], "types": ["T044"], "canonical_name": "pentose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156346", "aliases": ["arabinose biosynthesis", "arabinose synthesis", "arabinose formation", "arabinose anabolism"], "types": ["T044"], "canonical_name": "arabinose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose. [GOC:ai]"}
{"concept_id": "C1156347", "aliases": ["ribitol synthesis", "ribitol biosynthesis", "ribitol anabolism", "ribitol formation"], "types": ["T044"], "canonical_name": "ribitol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. [ISBN:0198506732]"}
{"concept_id": "C1156349", "aliases": ["deoxyribose phosphate formation", "deoxyribose phosphate biosynthesis", "deoxyribose phosphate synthesis", "deoxyribose phosphate anabolism"], "types": ["T044"], "canonical_name": "deoxyribose phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. [ISBN:0198506732]"}
{"concept_id": "C1156350", "aliases": ["2-deoxyribose 1-phosphate biosynthesis", "2-deoxyribose 1-phosphate formation", "2-deoxyribose 1-phosphate anabolism", "2-deoxyribose 1-phosphate synthesis"], "types": ["T044"], "canonical_name": "2-deoxyribose 1-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. [ISBN:0198506732]"}
{"concept_id": "C1156351", "aliases": ["deoxyribose 1,5-bisphosphate formation", "deoxyribose 1,5-bisphosphate synthesis", "deoxyribose 1,5-bisphosphate anabolism", "deoxyribose 1,5-bisphosphate biosynthesis"], "types": ["T044"], "canonical_name": "deoxyribose 1,5-bisphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose. [GOC:ai]"}
{"concept_id": "C1156352", "aliases": ["ribose phosphate anabolism", "ribose phosphate biosynthesis", "ribose phosphate synthesis", "ribose phosphate formation"], "types": ["T044"], "canonical_name": "ribose phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar. [GOC:ai]"}
{"concept_id": "C1156353", "aliases": ["5-phosphoribosyl-1-pyrophosphate biosynthesis", "5-phosphoribose 1-diphosphate formation", "5-phosphoribosyl-1-pyrophosphate biosynthetic process", "5-phosphoribose 1-diphosphate biosynthesis", "5-phosphoribose 1-diphosphate synthesis", "5-phosphoribose 1-diphosphate anabolism", "PRPP biosynthetic process"], "types": ["T044"], "canonical_name": "5-phosphoribose 1-diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. [GOC:ai]"}
{"concept_id": "C1156354", "aliases": ["xylulose formation", "xylulose biosynthesis", "xylulose anabolism", "xylulose synthesis"], "types": ["T044"], "canonical_name": "xylulose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose. [ISBN:0198547684]"}
{"concept_id": "C1156355", "aliases": ["octanol anabolism", "octanol formation", "octanol biosynthesis", "octanol synthesis"], "types": ["T044"], "canonical_name": "octanol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH. [GOC:ai]"}
{"concept_id": "C1156356", "aliases": [], "types": ["T044"], "canonical_name": "phenol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group. [GOC:mah]"}
{"concept_id": "C1156357", "aliases": ["aerobic phenol-containing compound biosynthesis", "aerobic phenol-containing compound formation", "aerobic phenol-containing compound anabolism", "aerobic phenol-containing compound synthesis"], "types": ["T044"], "canonical_name": "aerobic phenol-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. [GOC:ai]"}
{"concept_id": "C1156358", "aliases": ["anaerobic phenol-containing compound formation", "anaerobic phenol-containing compound synthesis", "anaerobic phenol-containing compound anabolism", "anaerobic phenol-containing compound biosynthesis"], "types": ["T044"], "canonical_name": "anaerobic phenol-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1156359", "aliases": ["polyhydric alcohol biosynthetic process", "polyol biosynthesis", "polyol formation", "polyol synthesis", "polyol anabolism"], "types": ["T044"], "canonical_name": "polyol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. [GOC:curators]"}
{"concept_id": "C1156360", "aliases": ["alditol synthesis", "alditol anabolism", "alditol formation", "alditol biosynthesis"], "types": ["T044"], "canonical_name": "alditol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. [ISBN:0198506732]"}
{"concept_id": "C1156361", "aliases": ["hexitol biosynthesis", "hexitol synthesis", "hexitol formation", "hexitol anabolism"], "types": ["T044"], "canonical_name": "hexitol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156362", "aliases": ["galactitol synthesis", "galactitol biosynthesis", "galactitol formation", "galactitol anabolism"], "types": ["T044"], "canonical_name": "galactitol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. [ISBN:0198506732]"}
{"concept_id": "C1156363", "aliases": ["mannitol anabolism", "mannitol synthesis", "mannitol formation", "mannitol biosynthesis"], "types": ["T044"], "canonical_name": "mannitol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1156364", "aliases": ["sorbitol synthesis", "sorbitol biosynthesis", "sorbitol anabolism", "sorbitol formation"], "types": ["T044"], "canonical_name": "sorbitol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1156365", "aliases": ["pentitol formation", "pentitol synthesis", "pentitol anabolism", "pentitol biosynthesis"], "types": ["T044"], "canonical_name": "pentitol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156366", "aliases": ["glycerol formation", "glycerol biosynthesis", "glycerol anabolism", "glycerol synthesis"], "types": ["T044"], "canonical_name": "glycerol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156367", "aliases": ["glycerol synthesis from pyruvate", "glycerol anabolism from pyruvate", "glyceroneogenesis", "glycerol formation from pyruvate"], "types": ["T044"], "canonical_name": "glycerol biosynthetic process from pyruvate", "definition": "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate. [GOC:ai]"}
{"concept_id": "C1156368", "aliases": ["glycerol-3-phosphate anabolism", "glycerol-3-phosphate synthesis", "glycerol-3-phosphate biosynthesis", "glycerol-3-phosphate formation"], "types": ["T044"], "canonical_name": "glycerol-3-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol. [GOC:ai]"}
{"concept_id": "C1156369", "aliases": ["alcohol catabolism", "alcohol breakdown", "alcohol degradation"], "types": ["T044"], "canonical_name": "alcohol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. [GOC:ai]"}
{"concept_id": "C1156370", "aliases": ["catechol breakdown", "catechol catabolic process", "catechol degradation"], "types": ["T044"], "canonical_name": "catechol catabolism"}
{"concept_id": "C1156371", "aliases": ["catechol degradation, meta-cleavage", "catechol breakdown, meta-cleavage"], "types": ["T044"], "canonical_name": "catechol catabolic process, meta-cleavage", "definition": "The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom. [GOC:jl, http://www.ence.umd.edu/]"}
{"concept_id": "C1156372", "aliases": ["catechol degradation, ortho-cleavage", "catechol breakdown, ortho-cleavage"], "types": ["T044"], "canonical_name": "catechol catabolic process, ortho-cleavage", "definition": "The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups. [GOC:jl, http://www.ence.umd.edu/]"}
{"concept_id": "C1156373", "aliases": ["gallate catabolism", "gallate degradation", "gallate breakdown", "gallic acid catabolism", "gallic acid catabolic process"], "types": ["T044"], "canonical_name": "gallate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). [GOC:jl]"}
{"concept_id": "C1156374", "aliases": ["aerobic gallic acid catabolism", "aerobic gallate degradation", "aerobic gallate catabolism", "aerobic gallic acid catabolic process", "aerobic gallate breakdown"], "types": ["T044"], "canonical_name": "aerobic gallate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen. [GOC:jl]"}
{"concept_id": "C1156375", "aliases": ["gallate degradation via 2-pyrone-4,6-dicarboxylate", "gallate breakdown via 2-pyrone-4,6-dicarboxylate", "gallic acid catabolism via 2-pyrone-4,6-dicarboxylate", "gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate"], "types": ["T044"], "canonical_name": "gallate catabolic process via 2-pyrone-4,6-dicarboxylate", "definition": "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate. [GOC:jl]"}
{"concept_id": "C1156376", "aliases": ["gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate", "gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate", "gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate", "gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate", "gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate"], "types": ["T044"], "canonical_name": "gallate catabolic process via gallate dioxygenase activity", "definition": "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, where the first step is the conversion of gallate to (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate catalyzed by gallate dioxygenase. [GOC:bf, GOC:jl]"}
{"concept_id": "C1156377", "aliases": ["anaerobic gallic acid catabolic process", "anaerobic gallate catabolism", "anaerobic gallate degradation", "anaerobic gallic acid catabolism", "gallate fermentation", "anaerobic gallate breakdown"], "types": ["T044"], "canonical_name": "anaerobic gallate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen. [GOC:jl]"}
{"concept_id": "C1156378", "aliases": ["methylgallate degradation", "methylgallate breakdown", "methylgallate catabolism"], "types": ["T044"], "canonical_name": "methylgallate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid. [GOC:ai]"}
{"concept_id": "C1156379", "aliases": ["protocatechuate breakdown", "protocatechuate degradation", "protocatechuate catabolic process", "protocatechuate catabolism"], "types": ["T044"], "canonical_name": "3,4-dihydroxybenzoate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. [GOC:ai]"}
{"concept_id": "C1156380", "aliases": ["protocatechuate catabolic process to oxaloacetate and pyruvate", "protocatechuate breakdown, meta-cleavage", "protocatechuate degradation, meta-cleavage"], "types": ["T044"], "canonical_name": "protocatechuate catabolic process, meta-cleavage", "definition": "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate. [MetaCyc:P184-PWY]"}
{"concept_id": "C1156381", "aliases": ["protocatechuate catabolic process to beta-ketoadipate", "protocatechuate degradation, ortho-cleavage", "3,4-dihydroxybenzoate catabolic process, ortho-cleavage", "protocatechuate breakdown, ortho-cleavage"], "types": ["T044"], "canonical_name": "protocatechuate catabolic process, ortho-cleavage", "definition": "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate. [MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY]"}
{"concept_id": "C1156382", "aliases": ["farnesol degradation", "farnesol breakdown", "farnesol catabolism"], "types": ["T044"], "canonical_name": "farnesol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. [GOC:go_curators]"}
{"concept_id": "C1156383", "aliases": ["glycolate catabolism", "glycolate breakdown", "glycolate degradation"], "types": ["T044"], "canonical_name": "glycolate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid). [GOC:ai]"}
{"concept_id": "C1156384", "aliases": ["methanol degradation", "methanol breakdown", "methanol catabolism"], "types": ["T044"], "canonical_name": "methanol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. [GOC:ai]"}
{"concept_id": "C1156385", "aliases": ["monosaccharide breakdown", "monosaccharide catabolism", "monosaccharide degradation"], "types": ["T044"], "canonical_name": "monosaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. [ISBN:0198506732]"}
{"concept_id": "C1156386", "aliases": ["hexose breakdown", "hexose degradation", "hexose catabolism"], "types": ["T044"], "canonical_name": "hexose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156387", "aliases": ["allose catabolism", "allose breakdown", "allose degradation"], "types": ["T044"], "canonical_name": "allose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. [ISBN:0198506732]"}
{"concept_id": "C1156388", "aliases": ["D-allose catabolism", "D-allose degradation", "D-allose breakdown"], "types": ["T044"], "canonical_name": "D-allose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1156389", "aliases": ["fructose breakdown", "fructose catabolism", "fructose degradation"], "types": ["T044"], "canonical_name": "fructose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose. [GOC:ai]"}
{"concept_id": "C1156390", "aliases": ["aerobic fructose breakdown", "aerobic fructose degradation", "aerobic fructose catabolism"], "types": ["T044"], "canonical_name": "aerobic fructose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen. [GOC:ai]"}
{"concept_id": "C1156391", "aliases": ["anaerobic fructose breakdown", "anaerobic fructose catabolism", "anaerobic fructose degradation"], "types": ["T044"], "canonical_name": "anaerobic fructose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1156392", "aliases": ["fucose breakdown", "fucose degradation", "fucose catabolism"], "types": ["T044"], "canonical_name": "fucose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose). [GOC:jl]"}
{"concept_id": "C1156393", "aliases": ["L-fucose degradation", "L-fucose breakdown", "L-fucose catabolism"], "types": ["T044"], "canonical_name": "L-fucose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose). [GOC:jl]"}
{"concept_id": "C1156394", "aliases": ["galactose degradation", "galactose catabolism", "galactose breakdown"], "types": ["T044"], "canonical_name": "galactose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose. [ISBN:0198506732]"}
{"concept_id": "C1156395", "aliases": ["glucose degradation", "glucose breakdown", "glucose catabolism"], "types": ["T044"], "canonical_name": "glucose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. [GOC:ai]"}
{"concept_id": "C1156396", "aliases": ["non-phosphorylated glucose catabolism", "non-phosphorylated glucose degradation", "non-phosphorylated glucose breakdown"], "types": ["T044"], "canonical_name": "non-phosphorylated glucose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose. [GOC:ai]"}
{"concept_id": "C1156397", "aliases": ["pentose phosphate shunt, non-oxidative branch", "pentose-phosphate pathway, non-oxidative branch", "pentose phosphate pathway, non-oxidative branch"], "types": ["T044"], "canonical_name": "pentose-phosphate shunt, non-oxidative branch", "definition": "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY]"}
{"concept_id": "C1156398", "aliases": ["pentose phosphate pathway, oxidative branch", "pentose phosphate shunt, oxidative branch", "oxidative pentose phosphate pathway", "pentose-phosphate pathway, oxidative branch", "oxidative branch, pentose pathway"], "types": ["T044"], "canonical_name": "pentose-phosphate shunt, oxidative branch", "definition": "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2). [ISBN:0198506732, MetaCyc:OXIDATIVEPENT-PWY]"}
{"concept_id": "C1156399", "aliases": ["mannose breakdown", "mannose catabolism", "mannose degradation"], "types": ["T044"], "canonical_name": "mannose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. [GOC:ai]"}
{"concept_id": "C1156400", "aliases": ["vitamin Bh catabolic process", "myo-inositol catabolic process", "inositol breakdown", "inositol catabolism", "vitamin Bh catabolism", "myo-inositol catabolism", "inositol degradation"], "types": ["T044"], "canonical_name": "inositol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. [GOC:go_curators]"}
{"concept_id": "C1156401", "aliases": ["rhamnose catabolism", "rhamnose breakdown", "rhamnose degradation"], "types": ["T044"], "canonical_name": "rhamnose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. [ISBN:0198506732]"}
{"concept_id": "C1156402", "aliases": ["anaerobic rhamnose catabolism", "anaerobic rhamnose degradation", "anaerobic rhamnose breakdown"], "types": ["T044"], "canonical_name": "anaerobic rhamnose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1156403", "aliases": ["pentose breakdown", "pentose catabolism", "pentose degradation"], "types": ["T044"], "canonical_name": "pentose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156404", "aliases": ["arabinose catabolism", "arabinose degradation", "arabinose breakdown"], "types": ["T044"], "canonical_name": "arabinose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose. [GOC:ai]"}
{"concept_id": "C1156405", "aliases": ["D-arabinose breakdown", "D-arabinose degradation", "D-arabinose catabolism"], "types": ["T044"], "canonical_name": "D-arabinose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose. [GOC:jsg, GOC:mah]"}
{"concept_id": "C1156406", "aliases": ["D-arabinose degradation to xylulose 5-phosphate", "D-arabinose breakdown to xylulose 5-phosphate"], "types": ["T044"], "canonical_name": "D-arabinose catabolic process to xylulose 5-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate. [GOC:go_curators]"}
{"concept_id": "C1156407", "aliases": ["L-arabinose catabolism", "L-arabinose degradation", "L-arabinose breakdown"], "types": ["T044"], "canonical_name": "L-arabinose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose. [GOC:jsg, GOC:mah]"}
{"concept_id": "C1156408", "aliases": ["L-arabinose catabolism to alpha-oxoglutarate", "L-arabinose catabolic process to alpha-ketoglutarate", "L-arabinose catabolism to 2-ketoglutarate", "L-arabinose breakdown to 2-oxoglutarate", "L-arabinose catabolic process to alpha-oxoglutarate", "L-arabinose degradation to 2-oxoglutarate", "L-arabinose catabolism to alpha-ketoglutarate", "L-arabinose catabolic process to 2-ketoglutarate"], "types": ["T044"], "canonical_name": "L-arabinose catabolic process to 2-oxoglutarate", "definition": "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate. [GOC:go_curators]"}
{"concept_id": "C1156409", "aliases": ["L-arabinose degradation to xylulose 5-phosphate", "L-arabinose breakdown to xylulose 5-phosphate"], "types": ["T044"], "canonical_name": "L-arabinose catabolic process to xylulose 5-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate. [GOC:go_curators]"}
{"concept_id": "C1156412", "aliases": ["deoxyribose phosphate catabolism", "deoxyribose phosphate degradation", "deoxyribose phosphate breakdown"], "types": ["T044"], "canonical_name": "deoxyribose phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. [ISBN:0198506732]"}
{"concept_id": "C1156413", "aliases": ["deoxyribose 1-phosphate catabolic process", "2-deoxyribose 1-phosphate breakdown", "2-deoxyribose 1-phosphate degradation", "2-deoxyribose 1-phosphate catabolism"], "types": ["T044"], "canonical_name": "2-deoxyribose 1-phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. [GOC:ai]"}
{"concept_id": "C1156414", "aliases": ["xylulose catabolism", "xylulose breakdown", "xylulose degradation"], "types": ["T044"], "canonical_name": "xylulose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose. [ISBN:0198547684]"}
{"concept_id": "C1156415", "aliases": ["octanol catabolism", "octanol degradation", "octanol breakdown"], "types": ["T044"], "canonical_name": "octanol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH. [GOC:ai]"}
{"concept_id": "C1156416", "aliases": [], "types": ["T044"], "canonical_name": "phenol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group. [GOC:mah]"}
{"concept_id": "C1156417", "aliases": ["aerobic phenol-containing compound degradation", "aerobic phenol-containing compound breakdown", "aerobic phenol-containing compound catabolism"], "types": ["T044"], "canonical_name": "aerobic phenol-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. [GOC:ai]"}
{"concept_id": "C1156418", "aliases": ["anaerobic phenol-containing compound catabolism", "anaerobic phenol-containing compound breakdown", "anaerobic phenol-containing compound degradation"], "types": ["T044"], "canonical_name": "anaerobic phenol-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. [GOC:ai]"}
{"concept_id": "C1156419", "aliases": ["polyhydric alcohol catabolic process", "polyol catabolism", "polyol degradation", "polyol breakdown"], "types": ["T044"], "canonical_name": "polyol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. [GOC:curators]"}
{"concept_id": "C1156420", "aliases": ["alditol degradation", "alditol catabolism", "alditol breakdown"], "types": ["T044"], "canonical_name": "alditol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. [ISBN:0198506732]"}
{"concept_id": "C1156421", "aliases": ["hexitol catabolism", "hexitol degradation", "hexitol breakdown"], "types": ["T044"], "canonical_name": "hexitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156422", "aliases": ["galactitol degradation", "galactitol catabolism", "galactitol breakdown"], "types": ["T044"], "canonical_name": "galactitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. [ISBN:0198506732]"}
{"concept_id": "C1156423", "aliases": ["mannitol catabolism", "mannitol breakdown", "mannitol degradation"], "types": ["T044"], "canonical_name": "mannitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1156424", "aliases": ["sorbitol degradation", "sorbitol breakdown", "sorbitol catabolism"], "types": ["T044"], "canonical_name": "sorbitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1156425", "aliases": ["pentitol degradation", "pentitol breakdown", "pentitol catabolism"], "types": ["T044"], "canonical_name": "pentitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156427", "aliases": ["D-arabitol degradation to xylulose 5-phosphate", "D-arabitol breakdown to xylulose 5-phosphate"], "types": ["T044"], "canonical_name": "D-arabitol catabolic process to xylulose 5-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate. [MetaCyc:DARABITOLUTIL-PWY]"}
{"concept_id": "C1156429", "aliases": ["L-xylitol breakdown to xylulose 5-phosphate", "L-xylitol degradation to xylulose 5-phosphate"], "types": ["T044"], "canonical_name": "L-xylitol catabolic process to xylulose 5-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate. [MetaCyc:LARABITOLUTIL-PWY]"}
{"concept_id": "C1156430", "aliases": ["glycerol catabolism", "glycerol breakdown", "glycerol degradation"], "types": ["T044"], "canonical_name": "glycerol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156432", "aliases": ["aerobic glycerol breakdown", "aerobic glycerol catabolism", "aerobic glycerol degradation"], "types": ["T044"], "canonical_name": "aerobic glycerol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156433", "aliases": ["glycerol-3-phosphate degradation", "glycerol-3-phosphate breakdown", "glycerol-3-phosphate catabolism"], "types": ["T044"], "canonical_name": "glycerol-3-phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. [GOC:ai]"}
{"concept_id": "C1156434", "aliases": ["acetyl-CoA synthesis from ethanol", "acetyl-CoA formation from ethanol", "acetyl-CoA anabolism from ethanol"], "types": ["T044"], "canonical_name": "acetyl-CoA biosynthetic process from ethanol", "definition": "The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde. [GOC:go_curators]"}
{"concept_id": "C1156435", "aliases": ["ethanol fermentation", "glucose catabolic process to ethanol", "glucose fermentation to ethanol"], "types": ["T044"], "canonical_name": "glycolytic fermentation to ethanol", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose. [GOC:dph, GOC:nr, ISBN:0716720094]"}
{"concept_id": "C1156436", "aliases": [], "types": ["T044"], "canonical_name": "ethanol oxidation", "definition": "An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. [GOC:mah, MetaCyc:PWY66-161, MetaCyc:PWY66-162, MetaCyc:PWY66-21]"}
{"concept_id": "C1156437", "aliases": ["ethanolamine metabolism"], "types": ["T044"], "canonical_name": "ethanolamine metabolic process", "definition": "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). [ISBN:0192800981]"}
{"concept_id": "C1156438", "aliases": ["ethanolamine biosynthesis", "ethanolamine synthesis", "ethanolamine anabolism", "ethanolamine formation"], "types": ["T044"], "canonical_name": "ethanolamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). [GOC:ai]"}
{"concept_id": "C1156439", "aliases": ["phosphatidylethanolamine biosynthesis", "phosphatidylethanolamine formation", "phosphatidylethanolamine anabolism", "phosphatidylethanolamine synthesis"], "types": ["T044"], "canonical_name": "phosphatidylethanolamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. [ISBN:0198506732]"}
{"concept_id": "C1156440", "aliases": [], "types": ["T044"], "canonical_name": "dihydrosphingosine-1-P pathway", "definition": "A phosphatidylethanolamine biosynthetic process that proceeds via the enzymatic action of dihydrosphingosine phosphate lyase. [GOC:mah, PMID:15643073]"}
{"concept_id": "C1156441", "aliases": ["phosphatidyl-N-monomethylethanolamine biosynthesis", "phosphatidyl-N-monomethylethanolamine synthesis", "PMME biosynthetic process", "phosphatidyl-N-monomethylethanolamine anabolism", "PMME biosynthesis", "phosphatidyl-N-monomethylethanolamine formation"], "types": ["T044"], "canonical_name": "phosphatidyl-N-monomethylethanolamine biosynthetic process", "definition": "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. [GOC:ai]"}
{"concept_id": "C1156442", "aliases": ["ethanolamine degradation", "ethanolamine breakdown", "ethanolamine catabolism"], "types": ["T044"], "canonical_name": "ethanolamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). [GOC:ai]"}
{"concept_id": "C1156443", "aliases": ["phosphatidylethanolamine catabolism", "phosphatidylethanolamine degradation", "phosphatidylethanolamine breakdown"], "types": ["T044"], "canonical_name": "phosphatidylethanolamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. [ISBN:0198506732]"}
{"concept_id": "C1156444", "aliases": ["farnesol metabolism"], "types": ["T044"], "canonical_name": "farnesol metabolic process", "definition": "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. [GOC:go_curators]"}
{"concept_id": "C1156445", "aliases": ["methanol metabolism"], "types": ["T044"], "canonical_name": "methanol metabolic process", "definition": "The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156446", "aliases": [], "types": ["T044"], "canonical_name": "methanol oxidation", "definition": "The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M. [MetaCyc:CO2FORM-PWY]"}
{"concept_id": "C1156447", "aliases": ["monosaccharide metabolism"], "types": ["T044"], "canonical_name": "monosaccharide metabolic process", "definition": "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. [ISBN:0198506732]"}
{"concept_id": "C1156448", "aliases": ["hexose metabolism"], "types": ["T044"], "canonical_name": "hexose metabolic process", "definition": "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156449", "aliases": ["allose metabolism"], "types": ["T044"], "canonical_name": "allose metabolic process", "definition": "The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. [ISBN:0198506732]"}
{"concept_id": "C1156450", "aliases": ["D-allose metabolism"], "types": ["T044"], "canonical_name": "D-allose metabolic process", "definition": "The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1156451", "aliases": ["fructose metabolism"], "types": ["T044"], "canonical_name": "fructose metabolic process", "definition": "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [ISBN:0198506732]"}
{"concept_id": "C1156452", "aliases": ["fructose 1,6-bisphosphate metabolism"], "types": ["T044"], "canonical_name": "fructose 1,6-bisphosphate metabolic process", "definition": "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. [ISBN:0198506732]"}
{"concept_id": "C1156453", "aliases": ["fructose 2,6-bisphosphate metabolism"], "types": ["T044"], "canonical_name": "fructose 2,6-bisphosphate metabolic process", "definition": "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. [ISBN:0198506732]"}
{"concept_id": "C1156454", "aliases": ["fructose 6-phosphate metabolism"], "types": ["T044"], "canonical_name": "fructose 6-phosphate metabolic process", "definition": "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. [ISBN:0198506732]"}
{"concept_id": "C1156455", "aliases": ["fucose metabolism"], "types": ["T044"], "canonical_name": "fucose metabolic process", "definition": "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. [ISBN:0198506732]"}
{"concept_id": "C1156456", "aliases": ["L-fucose metabolism"], "types": ["T044"], "canonical_name": "L-fucose metabolic process", "definition": "The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156457", "aliases": ["GDP-L-fucose metabolism"], "types": ["T044"], "canonical_name": "GDP-L-fucose metabolic process", "definition": "The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate. [GOC:ai]"}
{"concept_id": "C1156458", "aliases": ["galactose metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. [ISBN:0198506732]", "canonical_name": "galactose metabolic process"}
{"concept_id": "C1156459", "aliases": ["glucose 1-phosphate metabolism", "glucose 1-phosphate utilization"], "types": ["T044"], "canonical_name": "glucose 1-phosphate metabolic process", "definition": "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1. [GOC:ai]"}
{"concept_id": "C1156460", "aliases": [], "types": ["T044"], "canonical_name": "glucose 1-phosphate phosphorylation", "definition": "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate. [GOC:ai]"}
{"concept_id": "C1156463", "aliases": ["non-phosphorylated glucose metabolism"], "types": ["T044"], "canonical_name": "non-phosphorylated glucose metabolic process", "definition": "The chemical reactions and pathways involving non-phosphorylated forms of glucose. [GOC:ai]"}
{"concept_id": "C1156464", "aliases": ["UDP-glucose metabolism"], "types": ["T044"], "canonical_name": "UDP-glucose metabolic process", "definition": "The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1156465", "aliases": ["UDP-glucose degradation", "UDP-glucose breakdown", "UDP-glucose catabolism"], "types": ["T044"], "canonical_name": "UDP-glucose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1156466", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose conversion"}
{"concept_id": "C1156467", "aliases": ["mannose metabolism"], "types": ["T044"], "canonical_name": "mannose metabolic process", "definition": "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. [ISBN:0198506732]"}
{"concept_id": "C1156468", "aliases": ["dTDP-mannose metabolism"], "types": ["T044"], "canonical_name": "dTDP-mannose metabolic process", "definition": "The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate. [GOC:ai]"}
{"concept_id": "C1156469", "aliases": ["GDP-mannose metabolism"], "types": ["T044"], "canonical_name": "GDP-mannose metabolic process", "definition": "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. [GOC:ai]"}
{"concept_id": "C1156471", "aliases": ["rhamnose metabolism"], "types": ["T044"], "canonical_name": "rhamnose metabolic process", "definition": "The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. [ISBN:0198506732]"}
{"concept_id": "C1156472", "aliases": ["dTDP-rhamnose metabolism"], "types": ["T044"], "canonical_name": "dTDP-rhamnose metabolic process", "definition": "The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate. [GOC:ai]"}
{"concept_id": "C1156473", "aliases": ["GDP-D-rhamnose metabolism"], "types": ["T044"], "canonical_name": "GDP-D-rhamnose metabolic process", "definition": "The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate. [GOC:ai]"}
{"concept_id": "C1156474", "aliases": ["sorbose metabolism"], "types": ["T044"], "canonical_name": "sorbose metabolic process", "definition": "The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. [ISBN:0198506732]"}
{"concept_id": "C1156475", "aliases": ["L-sorbose metabolism"], "types": ["T044"], "canonical_name": "L-sorbose metabolic process", "definition": "The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol. [GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156476", "aliases": ["pentose metabolism"], "types": ["T044"], "canonical_name": "pentose metabolic process", "definition": "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156477", "aliases": ["arabinose metabolism"], "types": ["T044"], "canonical_name": "arabinose metabolic process", "definition": "The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides. [ISBN:0198506732]"}
{"concept_id": "C1156478", "aliases": ["D-arabinose metabolism"], "types": ["T044"], "canonical_name": "D-arabinose metabolic process", "definition": "The chemical reactions and pathways involving D-arabinose, the D-enantiomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides. [GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156479", "aliases": ["L-arabinose metabolism"], "types": ["T044"], "canonical_name": "L-arabinose metabolic process", "definition": "The chemical reactions and pathways involving L-arabinose, the D-enantiomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc. [GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156480", "aliases": ["L-lyxose metabolism"], "types": ["T044"], "canonical_name": "L-lyxose metabolic process", "definition": "The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose. [GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156481", "aliases": ["ribitol metabolism"], "types": ["T044"], "canonical_name": "ribitol metabolic process", "definition": "The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin. [ISBN:0198506732]"}
{"concept_id": "C1156482", "aliases": ["ribitol breakdown", "ribitol degradation", "ribitol catabolism"], "types": ["T044"], "canonical_name": "ribitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. [ISBN:0198506732]"}
{"concept_id": "C1156484", "aliases": ["deoxyribose phosphate metabolism"], "types": ["T044"], "canonical_name": "deoxyribose phosphate metabolic process", "definition": "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. [ISBN:0198506732]"}
{"concept_id": "C1156485", "aliases": ["2-deoxyribose 1-phosphate metabolism", "deoxyribose 1-phosphate metabolic process", "deoxyribose 1-phosphate metabolism"], "types": ["T044"], "canonical_name": "2-deoxyribose 1-phosphate metabolic process", "definition": "The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. [ISBN:0198506732]"}
{"concept_id": "C1156486", "aliases": ["deoxyribose 1,5-bisphosphate metabolism"], "types": ["T044"], "canonical_name": "deoxyribose 1,5-bisphosphate metabolic process", "definition": "The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose. [GOC:ai]"}
{"concept_id": "C1156488", "aliases": ["deoxyribose 5-phosphate metabolism"], "types": ["T044"], "canonical_name": "deoxyribose 5-phosphate metabolic process", "definition": "The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose. [GOC:ai]"}
{"concept_id": "C1156489", "aliases": [], "types": ["T044"], "canonical_name": "deoxyribose 5-phosphate phosphorylation", "definition": "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate. [GOC:ai]"}
{"concept_id": "C1156490", "aliases": ["ribose phosphate metabolism"], "types": ["T044"], "canonical_name": "ribose phosphate metabolic process", "definition": "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar. [GOC:ai]"}
{"concept_id": "C1156491", "aliases": ["5-phosphoribose 1-diphosphate metabolism", "PRPP metabolic process"], "types": ["T044"], "canonical_name": "5-phosphoribose 1-diphosphate metabolic process", "definition": "The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. [GOC:ai]"}
{"concept_id": "C1156492", "aliases": ["xylulose metabolism"], "types": ["T040"], "canonical_name": "xylulose metabolic process", "definition": "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose. [ISBN:0198547684]"}
{"concept_id": "C1156493", "aliases": ["octanol metabolism"], "types": ["T044"], "canonical_name": "octanol metabolic process", "definition": "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH. [GOC:go_curators]"}
{"concept_id": "C1156494", "aliases": ["hydroxybenzene metabolic process", "hydroxybenzene metabolism", "phenol-containing compound metabolism", "carbolic acid metabolism", "carbolic acid metabolic process"], "types": ["T044"], "canonical_name": "phenol-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. [ISBN:0198506732]"}
{"concept_id": "C1156495", "aliases": ["(R)-4-hydroxymandelate metabolism"], "types": ["T044"], "canonical_name": "(R)-4-hydroxymandelate metabolic process", "definition": "The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate). [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156496", "aliases": ["(R)-4-hydroxymandelate degradation", "(R)-4-hydroxymandelate breakdown", "(R)-4-hydroxymandelate catabolism"], "types": ["T044"], "canonical_name": "(R)-4-hydroxymandelate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid. [GOC:ai]"}
{"concept_id": "C1156497", "aliases": ["3-hydroxybenzyl alcohol metabolism"], "types": ["T044"], "canonical_name": "3-hydroxybenzyl alcohol metabolic process", "definition": "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum. [UM-BBD_pathwayID:mcr]"}
{"concept_id": "C1156498", "aliases": ["aerobic phenol-containing compound metabolism"], "types": ["T044"], "canonical_name": "aerobic phenol-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. [ISBN:0198506732]"}
{"concept_id": "C1156499", "aliases": ["anaerobic phenol-containing compound metabolism"], "types": ["T044"], "canonical_name": "anaerobic phenol-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. [PMID:12697029]"}
{"concept_id": "C1156500", "aliases": ["catechol metabolic process"], "types": ["T044"], "canonical_name": "catechol metabolism"}
{"concept_id": "C1156501", "aliases": ["(R)-mandelate degradation to catechol", "(R)-mandelate breakdown to catechol"], "types": ["T044"], "canonical_name": "(R)-mandelate catabolic process to catechol", "definition": "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol. [GOC:go_curators]"}
{"concept_id": "C1156503", "aliases": ["methylgallate metabolism"], "types": ["T044"], "canonical_name": "methylgallate metabolic process", "definition": "The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid. [GOC:ai]"}
{"concept_id": "C1156504", "aliases": ["protocatechuate metabolism", "protocatechuate metabolic process"], "types": ["T044"], "canonical_name": "3,4-dihydroxybenzoate metabolic process", "definition": "The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid). [GOC:ai, PMID:24359411]"}
{"concept_id": "C1156505", "aliases": [], "types": ["T044"], "canonical_name": "catechol-containing siderophore biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol. Catechol is one of the three major chemical groups incorporated into siderophore structures with hydroxamate and a-hydroxycarboxylate, each having a high selectivity for iron(3+). [PMID:20376388]"}
{"concept_id": "C1156506", "aliases": ["enterobactin anabolism", "enterochelin biosynthetic process", "enterobactin synthesis", "enterobactin biosynthesis", "enterobactin formation", "enterochelin biosynthesis"], "types": ["T044"], "canonical_name": "enterobactin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. [GOC:go_curators]"}
{"concept_id": "C1156507", "aliases": ["rhizobactin 1021 synthesis", "rhizobactin 1021 biosynthesis", "rhizobactin 1021 anabolism", "rhizobactin 1021 formation"], "types": ["T044"], "canonical_name": "rhizobactin 1021 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti. [PMID:11274118]"}
{"concept_id": "C1156508", "aliases": ["vibriobactin formation", "vibriobactin biosynthesis", "vibriobactin synthesis", "vibriobactin anabolism"], "types": ["T044"], "canonical_name": "vibriobactin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae. [GOC:jl, PMID:11112537]"}
{"concept_id": "C1156509", "aliases": ["tryptophan breakdown to catechol", "tryptophan degradation to catechol"], "types": ["T044"], "canonical_name": "tryptophan catabolic process to catechol", "definition": "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol. [GOC:go_curators]"}
{"concept_id": "C1156510", "aliases": ["catecholamine metabolism"], "types": ["T044"], "canonical_name": "catecholamine metabolic process", "definition": "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156511", "aliases": ["catecholamine synthesis", "catecholamine anabolism", "catecholamine formation", "catecholamine biosynthesis"], "types": ["T044"], "canonical_name": "catecholamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156512", "aliases": ["catecholamine catabolism", "catecholamine degradation", "catecholamine catabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:jl, ISBN:0198506732]", "canonical_name": "catecholamine breakdown"}
{"concept_id": "C1156513", "aliases": ["regulation of catecholamine metabolism"], "types": ["T043"], "canonical_name": "regulation of catecholamine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. [GOC:go_curators]"}
{"concept_id": "C1156514", "aliases": ["down regulation of catecholamine metabolic process", "negative regulation of catecholamine metabolism", "down-regulation of catecholamine metabolic process", "downregulation of catecholamine metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of catecholamine metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. [GOC:go_curators]"}
{"concept_id": "C1156515", "aliases": ["positive regulation of catecholamine metabolism", "upregulation of catecholamine metabolic process", "up-regulation of catecholamine metabolic process", "up regulation of catecholamine metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of catecholamine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. [GOC:go_curators]"}
{"concept_id": "C1156516", "aliases": ["polyhydric alcohol metabolic process", "polyol metabolism"], "types": ["T044"], "canonical_name": "polyol metabolic process", "definition": "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. [PMID:30240188]"}
{"concept_id": "C1156517", "aliases": ["alditol metabolism"], "types": ["T044"], "canonical_name": "alditol metabolic process", "definition": "The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. [ISBN:0198506732]"}
{"concept_id": "C1156518", "aliases": ["sugar alcohol (hexitol) metabolism", "hexitol metabolism", "sugar alcohol (hexitol) metabolic process"], "types": ["T044"], "canonical_name": "hexitol metabolic process", "definition": "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156519", "aliases": ["galactitol metabolism"], "types": ["T044"], "canonical_name": "galactitol metabolic process", "definition": "The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. [ISBN:0198506732]"}
{"concept_id": "C1156520", "aliases": ["mannitol metabolism"], "types": ["T044"], "canonical_name": "mannitol metabolic process", "definition": "The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1156521", "aliases": ["sorbitol metabolism"], "types": ["T044"], "canonical_name": "sorbitol metabolic process", "definition": "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1156522", "aliases": ["pentitol metabolism"], "types": ["T044"], "canonical_name": "pentitol metabolic process", "definition": "The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C1156523", "aliases": ["glycerol metabolism"], "types": ["T044"], "canonical_name": "glycerol metabolic process", "definition": "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156524", "aliases": ["glycerol fermentation"], "types": ["T044"], "canonical_name": "anaerobic glycerol catabolic process", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP. [GOC:mah]"}
{"concept_id": "C1156525", "aliases": ["glycerol fermentation to 1,3-propanediol", "glycerol fermentation to propane-1,3-diol"], "types": ["T044"], "canonical_name": "anaerobic glycerol catabolic process to propane-1,3-diol", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water. [GOC:jl, MetaCyc:GOLPDLCAT-PWY]"}
{"concept_id": "C1156526", "aliases": ["glycerol-3-phosphate metabolism"], "types": ["T044"], "canonical_name": "glycerol-3-phosphate metabolic process", "definition": "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156527", "aliases": ["(4E)-sphing-4-enine metabolic process", "sphing-4-enine metabolic process", "sphing-4-enine metabolism", "sphingosine metabolism", "(4E)-sphing-4-enine metabolism"], "types": ["T044"], "canonical_name": "sphingosine metabolic process", "definition": "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. [GOC:ma, ISBN:0198506732]"}
{"concept_id": "C1156528", "aliases": ["sphingosine biosynthesis", "sphingosine synthesis", "sphingosine anabolism", "sphingosine formation"], "types": ["T044"], "canonical_name": "sphingosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. [GOC:ma, ISBN:0198506732]"}
{"concept_id": "C1156529", "aliases": ["sterol metabolism"], "types": ["T044"], "canonical_name": "sterol metabolic process", "definition": "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [ISBN:0198547684]"}
{"concept_id": "C1156530", "aliases": ["cholesterol metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732]", "canonical_name": "cholesterol metabolic process"}
{"concept_id": "C1156531", "aliases": ["regulation of cholesterol synthesis", "regulation of cholesterol anabolism", "regulation of cholesterol biosynthesis", "regulation of cholesterol formation"], "types": ["T043"], "canonical_name": "regulation of cholesterol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. [GOC:go_curators]"}
{"concept_id": "C1156532", "aliases": ["downregulation of cholesterol biosynthetic process", "negative regulation of cholesterol anabolism", "negative regulation of cholesterol biosynthesis", "down-regulation of cholesterol biosynthetic process", "negative regulation of cholesterol synthesis", "down regulation of cholesterol biosynthetic process", "negative regulation of cholesterol formation"], "types": ["T043"], "canonical_name": "negative regulation of cholesterol biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. [GOC:go_curators]"}
{"concept_id": "C1156533", "aliases": ["up-regulation of cholesterol biosynthetic process", "positive regulation of cholesterol anabolism", "positive regulation of cholesterol biosynthesis", "positive regulation of cholesterol synthesis", "upregulation of cholesterol biosynthetic process", "up regulation of cholesterol biosynthetic process", "positive regulation of cholesterol formation"], "types": ["T043"], "canonical_name": "positive regulation of cholesterol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. [GOC:go_curators]"}
{"concept_id": "C1156534", "aliases": ["cholesterol degradation", "cholesterol breakdown", "cholesterol catabolism"], "types": ["T044"], "canonical_name": "cholesterol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai]"}
{"concept_id": "C1156535", "aliases": ["peptidyl-glycine cholesteryl ester formation from peptidyl-glycine", "peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine", "peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine"], "types": ["T044"], "canonical_name": "peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine", "definition": "The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins. [RESID:AA0309]"}
{"concept_id": "C1156536", "aliases": ["ecdysone metabolism"], "types": ["T044"], "canonical_name": "ecdysone metabolic process", "definition": "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development. [ISBN:0198506732]"}
{"concept_id": "C1156537", "aliases": ["ecdysone biosynthesis", "ecdysone formation", "ecdysone anabolism", "ecdysone synthesis"], "types": ["T044"], "canonical_name": "ecdysone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. [ISBN:0198506732]"}
{"concept_id": "C1156538", "aliases": ["ecdysone degradation", "ecdysone catabolism", "ecdysone breakdown"], "types": ["T044"], "canonical_name": "ecdysone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. [ISBN:0198506732]"}
{"concept_id": "C1156539", "aliases": [], "types": ["T044"], "canonical_name": "ecdysone modification", "definition": "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties. [GOC:jl]"}
{"concept_id": "C1156540", "aliases": ["ergosterol metabolism"], "types": ["T044"], "canonical_name": "ergosterol metabolic process", "definition": "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light. [ISBN:0198506732]"}
{"concept_id": "C1156541", "aliases": ["ergosterol anabolism", "ergosterol synthesis", "ergosterol formation", "ergosterol biosynthesis"], "types": ["T044"], "canonical_name": "ergosterol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. [ISBN:0198506732]"}
{"concept_id": "C1156542", "aliases": ["sterol biosynthetic process", "sterol formation", "sterol synthesis", "sterol anabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:go_curators]", "canonical_name": "sterol biosynthesis"}
{"concept_id": "C1156543", "aliases": ["sterol degradation", "sterol breakdown", "sterol catabolism"], "types": ["T044"], "canonical_name": "sterol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:go_curators]"}
{"concept_id": "C1156544", "aliases": ["alkanal metabolism", "alkanal metabolic process", "aldehyde metabolism"], "types": ["T044"], "canonical_name": "cellular aldehyde metabolic process", "definition": "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156545", "aliases": ["acetaldehyde metabolism", "ethanal metabolism", "ethanal metabolic process"], "types": ["T044"], "canonical_name": "acetaldehyde metabolic process", "definition": "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol. [GOC:go_curators]"}
{"concept_id": "C1156546", "aliases": ["acetaldehyde anabolism", "acetaldehyde synthesis", "acetaldehyde biosynthesis", "acetaldehyde formation"], "types": ["T044"], "canonical_name": "acetaldehyde biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol. [GOC:ai]"}
{"concept_id": "C1156547", "aliases": ["acetaldehyde degradation", "acetaldehyde catabolism", "acetaldehyde breakdown"], "types": ["T044"], "canonical_name": "acetaldehyde catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol. [GOC:ai]"}
{"concept_id": "C1156548", "aliases": ["aldehyde anabolism", "aldehyde biosynthesis", "aldehyde synthesis", "aldehyde formation"], "types": ["T044"], "canonical_name": "aldehyde biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O. [GOC:ai]"}
{"concept_id": "C1156549", "aliases": ["formaldehyde anabolism", "formaldehyde synthesis", "methanal biosynthetic process", "formaldehyde formation", "formaldehyde biosynthesis", "methanal biosynthesis"], "types": ["T044"], "canonical_name": "formaldehyde biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde. [GOC:ai]"}
{"concept_id": "C1156550", "aliases": ["glyceraldehyde 3-phosphate biosynthetic process", "glyceraldehyde-3-phosphate anabolism", "glyceraldehyde 3-phosphate biosynthesis", "glyceraldehyde-3-phosphate biosynthesis", "glyceraldehyde-3-phosphate synthesis", "glyceraldehyde-3-phosphate formation"], "types": ["T044"], "canonical_name": "glyceraldehyde-3-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis. [GOC:ai]"}
{"concept_id": "C1156551", "aliases": ["palmitaldehyde biosynthetic process", "hexadecanal biosynthesis", "palmitaldehyde biosynthesis", "hexadecanal formation", "hexadecanal synthesis", "hexadecanal anabolism"], "types": ["T044"], "canonical_name": "hexadecanal biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde. [http://chemfinder.cambridgesoft.com/]"}
{"concept_id": "C1156552", "aliases": ["methylglyoxal anabolism", "methylglyoxal synthesis", "methylglyoxal formation", "methylglyoxal biosynthesis"], "types": ["T044"], "canonical_name": "methylglyoxal biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. [GOC:ai]"}
{"concept_id": "C1156553", "aliases": ["aldehyde breakdown", "aldehyde catabolism", "aldehyde degradation"], "types": ["T044"], "canonical_name": "aldehyde catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. [GOC:ai]"}
{"concept_id": "C1156554", "aliases": ["methanal catabolism", "formaldehyde degradation", "formaldehyde breakdown", "methanal catabolic process", "formaldehyde catabolism"], "types": ["T044"], "canonical_name": "formaldehyde catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. [GOC:ai]"}
{"concept_id": "C1156555", "aliases": ["glyceraldehyde-3-phosphate degradation", "glyceraldehyde 3-phosphate catabolic process", "glyceraldehyde-3-phosphate breakdown", "glyceraldehyde 3-phosphate catabolism", "glyceraldehyde-3-phosphate catabolism"], "types": ["T044"], "canonical_name": "glyceraldehyde-3-phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis. [ISBN:0198506732]"}
{"concept_id": "C1156556", "aliases": ["glyoxylate breakdown", "glyoxylate catabolism", "glyoxylate degradation"], "types": ["T044"], "canonical_name": "glyoxylate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH. [ISBN:0198506732]"}
{"concept_id": "C1156557", "aliases": ["methylglyoxal breakdown", "methylglyoxal degradation", "methylglyoxal catabolism"], "types": ["T044"], "canonical_name": "methylglyoxal catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. [GOC:ai]"}
{"concept_id": "C1156558", "aliases": ["formaldehyde metabolism", "methanal metabolism", "methanal metabolic process"], "types": ["T044"], "canonical_name": "formaldehyde metabolic process", "definition": "The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent. [GOC:ai]"}
{"concept_id": "C1156559", "aliases": [], "types": ["T044"], "canonical_name": "formaldehyde assimilation", "definition": "The pathways in which formaldehyde is processed and used as a carbon source for the cell. [GOC:ai]"}
{"concept_id": "C1156560", "aliases": ["formaldehyde assimilation via RuMP cycle"], "types": ["T044"], "canonical_name": "formaldehyde assimilation via ribulose monophosphate cycle", "definition": "The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde. [MetaCyc:PWY-1861]"}
{"concept_id": "C1156561", "aliases": ["formaldehyde fixation cycle", "formaldehyde assimilation via xylulose-5-phosphate cycle"], "types": ["T044"], "canonical_name": "formaldehyde assimilation via xylulose monophosphate cycle", "definition": "The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds. [MetaCyc:P185-PWY]"}
{"concept_id": "C1156562", "aliases": ["glyceraldehyde 3-phosphate metabolic process", "glyceraldehyde-3-phosphate metabolism", "glyceraldehyde 3-phosphate metabolism"], "types": ["T044"], "canonical_name": "glyceraldehyde-3-phosphate metabolic process", "definition": "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156563", "aliases": ["glyoxylate metabolism"], "types": ["T044"], "canonical_name": "glyoxylate metabolic process", "definition": "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. [ISBN:0198506732]"}
{"concept_id": "C1156564", "aliases": ["glyoxylate bypass"], "types": ["T044"], "canonical_name": "glyoxylate cycle", "definition": "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. [ISBN:0198506732]"}
{"concept_id": "C1156565", "aliases": ["hexadecanal metabolism"], "types": ["T044"], "canonical_name": "hexadecanal metabolic process", "definition": "The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde. [PMID:25047030]"}
{"concept_id": "C1156566", "aliases": ["methylglyoxal metabolism"], "types": ["T044"], "canonical_name": "methylglyoxal metabolic process", "definition": "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. [GOC:ai]"}
{"concept_id": "C1156567", "aliases": ["methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione"], "types": ["T044"], "canonical_name": "methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione", "definition": "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step. [GOC:ai, GOC:dph, PMID:2198020]"}
{"concept_id": "C1156568", "aliases": ["vanillic aldehyde metabolism", "vanillic aldehyde metabolic process", "vanillin metabolism"], "types": ["T044"], "canonical_name": "vanillin metabolic process", "definition": "The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin. [GOC:jl]"}
{"concept_id": "C1156569", "aliases": ["vanillin synthesis", "vanillin biosynthesis", "vanillin anabolism", "vanillic aldehyde biosynthetic process", "vanillic aldehyde biosynthesis", "vanillin formation"], "types": ["T044"], "canonical_name": "vanillin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods. [GOC:jl]"}
{"concept_id": "C1156570", "aliases": ["vanillic aldehyde catabolic process", "vanillin degradation", "vanillic aldehyde catabolism", "vanillin catabolism", "vanillin breakdown"], "types": ["T044"], "canonical_name": "vanillin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods. [GOC:jl]"}
{"concept_id": "C1156571", "aliases": ["amine metabolism"], "types": ["T044"], "canonical_name": "amine metabolic process", "definition": "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156572", "aliases": ["ACP metabolic process", "1-aminocyclopropane-1-carboxylate metabolism", "ACP metabolism"], "types": ["T044"], "canonical_name": "1-aminocyclopropane-1-carboxylate metabolic process", "definition": "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. [UM-BBD_pathwayID:acp]"}
{"concept_id": "C1156573", "aliases": ["3-keto-dihydrosphingosine metabolic process", "3-keto-dihydrosphingosine metabolism", "3-keto-sphinganine metabolism"], "types": ["T044"], "canonical_name": "3-keto-sphinganine metabolic process", "definition": "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine. [GOC:ai]"}
{"concept_id": "C1156574", "aliases": ["4-hydroxyproline metabolism"], "types": ["T044"], "canonical_name": "4-hydroxyproline metabolic process", "definition": "The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. [GOC:ai]"}
{"concept_id": "C1156575", "aliases": ["4-hydroxyproline anabolism", "4-hydroxyproline formation", "4-hydroxyproline synthesis", "4-hydroxyproline biosynthesis"], "types": ["T044"], "canonical_name": "4-hydroxyproline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. [GOC:ai]"}
{"concept_id": "C1156576", "aliases": ["4-hydroxyproline breakdown", "4-hydroxyproline catabolism", "4-hydroxyproline degradation"], "types": ["T044"], "canonical_name": "4-hydroxyproline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. [GOC:ai]"}
{"concept_id": "C1156577", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-proline hydroxylation to 4-hydroxy-L-proline", "definition": "The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase. [RESID:AA0030]"}
{"concept_id": "C1156578", "aliases": ["allantoin metabolism"], "types": ["T044"], "canonical_name": "allantoin metabolic process", "definition": "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1156580", "aliases": ["allantoin formation", "allantoin biosynthesis", "allantoin anabolism", "allantoin synthesis"], "types": ["T044"], "canonical_name": "allantoin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. [GOC:go_curators]"}
{"concept_id": "C1156581", "aliases": ["allantoin degradation", "allantoin catabolism", "allantoin breakdown"], "types": ["T044"], "canonical_name": "allantoin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1156582", "aliases": ["amine formation", "amine biosynthesis", "amine anabolism", "amine synthesis"], "types": ["T044"], "canonical_name": "amine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156583", "aliases": ["aromatic amino acid family formation", "aromatic amino acid family synthesis", "aromatic amino acid family biosynthesis", "aromatic amino acid family anabolism"], "types": ["T044"], "canonical_name": "aromatic amino acid family biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). [GOC:go_curators]"}
{"concept_id": "C1156585", "aliases": ["tryptophan biosynthesis", "aromatic amino acid family biosynthetic process, anthranilate pathway", "tryptophan formation", "tryptophan synthesis", "tryptophan anabolism"], "types": ["T044"], "canonical_name": "tryptophan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY]"}
{"concept_id": "C1156586", "aliases": ["aromatic amino acid family biosynthetic process via prephenate(2-)", "aromatic amino acid family formation, prephenate pathway", "aromatic amino acid family synthesis, prephenate pathway", "aromatic amino acid family biosynthetic process via prephenate", "aromatic amino acid family anabolism, prephenate pathway"], "types": ["T044"], "canonical_name": "aromatic amino acid family biosynthetic process, prephenate pathway", "definition": "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate. [GOC:mah, ISBN:0471331309]"}
{"concept_id": "C1156587", "aliases": ["shikimate pathway", "chorismate formation", "chorismate anabolism", "chorismate synthesis", "chorismate biosynthesis"], "types": ["T044"], "canonical_name": "chorismate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds. [GOC:sm, ISBN:0198547684]"}
{"concept_id": "C1156589", "aliases": ["tyrosine anabolism", "tyrosine biosynthesis", "tyrosine formation", "tyrosine synthesis"], "types": ["T044"], "canonical_name": "tyrosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. [GOC:sm]"}
{"concept_id": "C1156590", "aliases": ["tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate", "tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate", "tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate", "tyrosine formation from chorismate via 4-hydroxyphenylpyruvate"], "types": ["T044"], "canonical_name": "tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate", "definition": "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate. [GOC:go_curators]"}
{"concept_id": "C1156592", "aliases": ["L-tyrosine biosynthesis IV", "tyrosine anabolism, by oxidation of phenylalanine", "tyrosine synthesis, by oxidation of phenylalanine", "tyrosine formation, by oxidation of phenylalanine"], "types": ["T044"], "canonical_name": "tyrosine biosynthetic process, by oxidation of phenylalanine", "definition": "The conversion of phenylalanine to tyrosine. [PMID:4004813]"}
{"concept_id": "C1156594", "aliases": [], "types": ["T044"], "canonical_name": "aromatic amino acid family biosynthetic process, shikimate pathway"}
{"concept_id": "C1156596", "aliases": ["aspartate family amino acid anabolism", "aspartate family amino acid formation", "aspartate family amino acid synthesis", "aspartate family amino acid biosynthesis"], "types": ["T044"], "canonical_name": "aspartate family amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. [GOC:ai]"}
{"concept_id": "C1156597", "aliases": ["asparagine synthesis", "asparagine formation", "asparagine biosynthesis", "asparagine anabolism"], "types": ["T044"], "canonical_name": "asparagine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156598", "aliases": ["asparagine synthesis from cysteine", "asparagine formation from cysteine", "asparagine anabolism from cysteine"], "types": ["T044"], "canonical_name": "asparagine biosynthetic process from cysteine", "definition": "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine. [GOC:go_curators]"}
{"concept_id": "C1156599", "aliases": ["asparagine anabolism from oxaloacetate", "asparagine synthesis from oxaloacetate", "asparagine formation from oxaloacetate"], "types": ["T044"], "canonical_name": "asparagine biosynthetic process from oxaloacetate", "definition": "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate. [GOC:go_curators]"}
{"concept_id": "C1156600", "aliases": ["aspartate formation", "aspartate synthesis", "aspartate biosynthesis", "aspartate anabolism"], "types": ["T044"], "canonical_name": "aspartate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156601", "aliases": ["lysine formation", "lysine biosynthetic process", "lysine anabolism", "lysine biosynthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid. [GOC:go_curators]", "canonical_name": "lysine synthesis"}
{"concept_id": "C1156602", "aliases": ["aerobactin anabolism", "aerobactin formation", "aerobactin synthesis", "aerobactin biosynthesis"], "types": ["T044"], "canonical_name": "aerobactin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. [GOC:ai]"}
{"concept_id": "C1156603", "aliases": ["diaminopimelic acid pathway", "diaminopimelate pathway", "lysine synthesis via diaminopimelate", "lysine formation via diaminopimelate", "lysine biosynthetic process via diaminopimelic acid", "lysine biosynthesis via diaminopimelic acid", "lysine anabolism via diaminopimelate"], "types": ["T044"], "canonical_name": "lysine biosynthetic process via diaminopimelate", "definition": "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. [GOC:go_curators]"}
{"concept_id": "C1156604", "aliases": ["diaminopimelate biosynthesis", "diaminopimelate anabolism", "diaminopimelate formation", "diaminopimelate synthesis"], "types": ["T044"], "canonical_name": "diaminopimelate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. [GOC:ma, ISBN:0198547684]"}
{"concept_id": "C1156605", "aliases": ["lysine formation via aminoadipic acid", "lysine biosynthesis, aminoadipic pathway", "lysine synthesis via aminoadipic acid", "lysine biosynthesis, aminoadipic acid pathway", "lysine biosynthetic process, aminoadipic pathway", "lysine anabolism via aminoadipic acid", "lysine biosynthetic process, aminoadipic acid pathway"], "types": ["T044"], "canonical_name": "lysine biosynthetic process via aminoadipic acid", "definition": "The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. [GOC:go_curators]"}
{"concept_id": "C1156606", "aliases": ["methionine biosynthesis", "methionine formation", "methionine synthesis", "methionine anabolism"], "types": ["T044"], "canonical_name": "methionine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156608", "aliases": ["methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine", "L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine", "L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine", "L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine"], "types": ["T044"], "canonical_name": "L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine", "definition": "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine. [GOC:go_curators]"}
{"concept_id": "C1156609", "aliases": ["methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine", "L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine", "L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine", "L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine"], "types": ["T044"], "canonical_name": "L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine", "definition": "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine. [GOC:go_curators]"}
{"concept_id": "C1156611", "aliases": ["L-methionine formation from S-adenosylmethionine", "L-methionine synthesis from S-adenosylmethionine"], "types": ["T044"], "canonical_name": "L-methionine salvage from S-adenosylmethionine", "definition": "The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine. [GOC:go_curators, GOC:vw]"}
{"concept_id": "C1156613", "aliases": ["threonine synthesis", "threonine formation", "threonine biosynthesis", "threonine anabolism"], "types": ["T044"], "canonical_name": "threonine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156614", "aliases": ["branched chain family amino acid formation", "branched chain family amino acid anabolism", "branched chain family amino acid biosynthetic process", "branched chain family amino acid biosynthesis", "branched chain family amino acid synthesis"], "types": ["T044"], "canonical_name": "branched-chain amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. [GOC:ai]"}
{"concept_id": "C1156615", "aliases": ["isoleucine synthesis", "isoleucine formation", "isoleucine anabolism", "isoleucine biosynthesis"], "types": ["T044"], "canonical_name": "isoleucine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. [GOC:ai]"}
{"concept_id": "C1156616", "aliases": ["leucine biosynthesis", "leucine anabolism", "leucine formation", "leucine synthesis"], "types": ["T044"], "canonical_name": "leucine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. [GOC:ai]"}
{"concept_id": "C1156617", "aliases": ["valine anabolism", "valine biosynthesis", "valine synthesis", "valine formation"], "types": ["T044"], "canonical_name": "valine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid. [GOC:ai]"}
{"concept_id": "C1156618", "aliases": ["D-amino acid formation", "D-amino acid synthesis", "D-amino acid biosynthesis", "D-amino acid anabolism"], "types": ["T044"], "canonical_name": "D-amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-amino acids, the D-enantiomers of amino acids. [GOC:ai, GOC:jsg]"}
{"concept_id": "C1156619", "aliases": ["D-alanine biosynthesis", "D-alanine formation", "D-alanine anabolism", "D-alanine synthesis"], "types": ["T044"], "canonical_name": "D-alanine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid. [GOC:jsg, GOC:mah]"}
{"concept_id": "C1156620", "aliases": ["glutamine family amino acid anabolism", "glutamine family amino acid synthesis", "glutamine family amino acid formation", "glutamine family amino acid biosynthesis"], "types": ["T044"], "canonical_name": "glutamine family amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. [GOC:ai]"}
{"concept_id": "C1156621", "aliases": ["arginine anabolism", "arginine formation", "arginine synthesis", "arginine biosynthesis"], "types": ["T044"], "canonical_name": "arginine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [ISBN:0198506732]"}
{"concept_id": "C1156622", "aliases": ["arginine formation via ornithine", "arginine synthesis via ornithine", "arginine anabolism via ornithine"], "types": ["T044"], "canonical_name": "arginine biosynthetic process via ornithine", "definition": "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. [GOC:jl]"}
{"concept_id": "C1156623", "aliases": ["glutamic acid biosynthesis", "glutamate anabolism", "glutamate synthesis", "glutamate biosynthesis", "glutamic acid biosynthetic process", "glutamate formation"], "types": ["T044"], "canonical_name": "glutamate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. [GOC:go_curators]"}
{"concept_id": "C1156624", "aliases": ["glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)", "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)"], "types": ["T044"], "canonical_name": "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)", "definition": "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+). [GOC:go_curators]"}
{"concept_id": "C1156625", "aliases": ["glutamate biosynthetic process, using glutamate synthase (NADPH)"], "types": ["T044"], "canonical_name": "glutamate biosynthesis, using glutamate synthase (NADPH)", "definition": "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH). [GOC:go_curators]"}
{"concept_id": "C1156626", "aliases": ["glutamine anabolism", "glutamine formation", "glutamine synthesis", "glutamine biosynthesis"], "types": ["T044"], "canonical_name": "glutamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. [GOC:ai]"}
{"concept_id": "C1156627", "aliases": ["proline synthesis", "proline formation", "proline anabolism", "proline biosynthesis"], "types": ["T044"], "canonical_name": "proline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. [ISBN:0198506732]"}
{"concept_id": "C1156629", "aliases": ["histidine formation", "histidine anabolism", "histidine synthesis", "histidine biosynthesis"], "types": ["T044"], "canonical_name": "histidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156631", "aliases": ["beta-alanine anabolism", "beta-alanine formation", "beta-alanine synthesis", "beta-alanine biosynthesis"], "types": ["T044"], "canonical_name": "beta-alanine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156632", "aliases": ["ornithine biosynthesis", "ornithine formation", "ornithine anabolism", "ornithine synthesis"], "types": ["T044"], "canonical_name": "ornithine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156633", "aliases": ["pyruvate family amino acid synthesis", "pyruvate family amino acid anabolism", "pyruvate family amino acid biosynthesis", "pyruvate family amino acid formation"], "types": ["T044"], "canonical_name": "pyruvate family amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine. [GOC:jl]"}
{"concept_id": "C1156634", "aliases": ["alanine anabolism", "alanine synthesis", "alanine biosynthesis", "alanine formation"], "types": ["T044"], "canonical_name": "alanine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156637", "aliases": ["D-alanine family amino acid anabolism", "D-alanine family amino acid synthesis", "D-alanine family amino acid biosynthesis", "D-alanine family amino acid formation"], "types": ["T044"], "canonical_name": "D-alanine family amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids. [GOC:ai]"}
{"concept_id": "C1156638", "aliases": ["serine family amino acid biosynthesis", "serine family amino acid anabolism", "serine family amino acid synthesis", "serine family amino acid formation"], "types": ["T044"], "canonical_name": "serine family amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. [GOC:ai]"}
{"concept_id": "C1156639", "aliases": ["cysteine formation", "cysteine synthesis", "cysteine anabolism", "cysteine biosynthesis"], "types": ["T044"], "canonical_name": "cysteine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156640", "aliases": ["cysteine anabolism from serine", "cysteine formation from serine", "cysteine synthesis from serine"], "types": ["T044"], "canonical_name": "cysteine biosynthetic process from serine", "definition": "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. [GOC:go_curators]"}
{"concept_id": "C1156642", "aliases": ["cysteine formation via S-sulfo-L-cysteine", "cysteine anabolism via S-sulfo-L-cysteine", "cysteine synthesis via S-sulfo-L-cysteine", "cysteine biosynthetic process via S-sulpho-L-cysteine", "cysteine biosynthesis via S-sulpho-L-cysteine"], "types": ["T044"], "canonical_name": "cysteine biosynthetic process via S-sulfo-L-cysteine", "definition": "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine. [GOC:go_curators]"}
{"concept_id": "C1156643", "aliases": ["glycine biosynthesis", "glycine formation", "glycine synthesis", "glycine anabolism"], "types": ["T044"], "canonical_name": "glycine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156644", "aliases": ["glycine synthesis from serine", "glycine anabolism from serine", "glycine formation from serine"], "types": ["T044"], "canonical_name": "glycine biosynthetic process from serine", "definition": "The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine. [GOC:go_curators]"}
{"concept_id": "C1156645", "aliases": ["glycine formation, by transamination of glyoxylate", "glycine anabolism, by transamination of glyoxylate", "glycine synthesis, by transamination of glyoxylate"], "types": ["T044"], "canonical_name": "glycine biosynthetic process, by transamination of glyoxylate", "definition": "The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate. [GOC:go_curators]"}
{"concept_id": "C1156646", "aliases": ["homoserine formation", "homoserine synthesis", "homoserine anabolism", "homoserine biosynthesis"], "types": ["T044"], "canonical_name": "homoserine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156647", "aliases": ["selenocysteine formation", "selenocysteine biosynthesis", "selenocysteine anabolism", "selenocysteine synthesis"], "types": ["T044"], "canonical_name": "selenocysteine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156649", "aliases": ["sulfur amino acid synthesis", "sulfur amino acid biosynthesis", "sulphur amino acid biosynthetic process", "sulphur amino acid biosynthesis", "sulfur amino acid formation", "sulfur amino acid anabolism"], "types": ["T044"], "canonical_name": "sulfur amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. [GOC:ai]"}
{"concept_id": "C1156650", "aliases": ["methionine salvage from methylthioadenosine", "methionine salvage pathway"], "types": ["T044"], "canonical_name": "L-methionine salvage from methylthioadenosine", "definition": "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. [GOC:jl, MetaCyc:PWY-4361]"}
{"concept_id": "C1156651", "aliases": ["S-adenosylmethionine synthesis", "S-adenosylmethionine anabolism", "SAM biosynthetic process", "S-adenosyl methionine biosynthesis", "S-adenosyl methionine biosynthetic process", "S-adenosylmethionine formation", "S-adenosylmethionine biosynthesis"], "types": ["T044"], "canonical_name": "S-adenosylmethionine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156652", "aliases": ["biogenic amine anabolism", "biogenic amine synthesis", "biogenic amine formation", "biogenic amine biosynthesis"], "types": ["T044"], "canonical_name": "cellular biogenic amine biosynthetic process", "definition": "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. [GOC:jl, ISBN:0395825172]"}
{"concept_id": "C1156653", "aliases": ["betaine anabolism", "betaine synthesis", "betaine formation", "betaine biosynthesis", "betaine biosynthetic process"], "types": ["T044"], "canonical_name": "amino-acid betaine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156654", "aliases": ["glycine betaine synthesis from choline", "N-trimethylglycine biosynthesis from choline", "glycine betaine formation from choline", "choline oxidation", "N-trimethylglycine biosynthetic process from choline", "glycine betaine anabolism from choline"], "types": ["T044"], "canonical_name": "glycine betaine biosynthetic process from choline", "definition": "The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline. [GOC:jl]"}
{"concept_id": "C1156656", "aliases": ["carnitine synthesis", "vitamin Bt biosynthesis", "vitamin Bt biosynthetic process", "carnitine anabolism", "carnitine formation", "carnitine biosynthesis"], "types": ["T044"], "canonical_name": "carnitine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156657", "aliases": ["choline synthesis", "choline anabolism", "choline formation", "choline biosynthesis"], "types": ["T044"], "canonical_name": "choline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156658", "aliases": ["indolalkylamine biosynthesis", "indolalkylamine formation", "indolalkylamine anabolism", "indolalkylamine synthesis"], "types": ["T044"], "canonical_name": "indolalkylamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. [GOC:curators]"}
{"concept_id": "C1156659", "aliases": ["melatonin formation", "melatonin synthesis", "melatonin biosynthesis", "melatonin anabolism"], "types": ["T044"], "canonical_name": "melatonin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine). [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156660", "aliases": ["nicotianamine synthesis", "nicotianamine formation", "nicotianamine biosynthesis", "nicotianamine anabolism"], "types": ["T044"], "canonical_name": "nicotianamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. [GOC:mah, PMID:10069850]"}
{"concept_id": "C1156661", "aliases": ["polyamine synthesis", "polyamine biosynthesis", "polyamine formation", "polyamine anabolism"], "types": ["T044"], "canonical_name": "polyamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]"}
{"concept_id": "C1156662", "aliases": ["putrescine formation", "putrescine biosynthesis", "putrescine anabolism", "putrescine synthesis"], "types": ["T044"], "canonical_name": "putrescine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156663", "aliases": ["spermidine formation", "spermidine synthesis", "spermidine anabolism", "spermidine biosynthesis"], "types": ["T044"], "canonical_name": "spermidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156664", "aliases": ["nor-spermidine synthesis", "nor-spermidine biosynthesis", "nor-spermidine formation", "nor-spermidine anabolism"], "types": ["T044"], "canonical_name": "nor-spermidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:go_curators]"}
{"concept_id": "C1156665", "aliases": ["trypanothione synthesis", "trypanothione biosynthesis", "trypanothione formation", "trypanothione anabolism"], "types": ["T044"], "canonical_name": "trypanothione biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress. [MetaCyc:TRYPANOSYN-PWY, PMID:9677355]"}
{"concept_id": "C1156666", "aliases": ["spermine biosynthesis", "spermine anabolism", "spermine synthesis", "spermine formation"], "types": ["T044"], "canonical_name": "spermine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. [GOC:curators]"}
{"concept_id": "C1156667", "aliases": ["amine degradation", "amine breakdown", "amine catabolism"], "types": ["T044"], "canonical_name": "amine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156668", "aliases": ["cellular amino acid catabolism", "cellular amino acid degradation", "amino acid catabolic process", "cellular amino acid breakdown"], "types": ["T044"], "canonical_name": "cellular amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. [GOC:ai]"}
{"concept_id": "C1156669", "aliases": ["aromatic amino acid family catabolism", "aromatic amino acid family degradation", "aromatic amino acid family breakdown"], "types": ["T044"], "canonical_name": "aromatic amino acid family catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). [GOC:go_curators]"}
{"concept_id": "C1156670", "aliases": ["L-phenylalanine degradation", "L-phenylalanine breakdown", "L-phenylalanine catabolism"], "types": ["T044"], "canonical_name": "L-phenylalanine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156671", "aliases": [], "types": ["T044"], "canonical_name": "anaerobic phenylalanine oxidation", "definition": "The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde. [GOC:mah, MetaCyc:ANAPHENOXI-PWY]"}
{"concept_id": "C1156673", "aliases": ["tryptophan degradation", "tryptophan catabolism", "tryptophan breakdown"], "types": ["T044"], "canonical_name": "tryptophan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [ISBN:0198547684]"}
{"concept_id": "C1156674", "aliases": ["tryptophan degradation to acetyl-CoA", "tryptophan breakdown to acetyl-CoA"], "types": ["T044"], "canonical_name": "tryptophan catabolic process to acetyl-CoA", "definition": "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA. [GOC:go_curators]"}
{"concept_id": "C1156675", "aliases": ["tryptophan catabolic process to IAA", "tryptophan catabolic process to indoleacetic acid", "tryptophan breakdown to indole-3-acetate", "tryptophan degradation to indole-3-acetate", "tryptophan catabolism to indoleacetic acid"], "types": ["T044"], "canonical_name": "tryptophan catabolic process to indole-3-acetate", "definition": "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate. [GOC:go_curators]"}
{"concept_id": "C1156676", "aliases": ["tryptophan degradation to kynurenine", "tryptophan breakdown to kynurenine"], "types": ["T044"], "canonical_name": "tryptophan catabolic process to kynurenine", "definition": "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. [GOC:go_curators]"}
{"concept_id": "C1156678", "aliases": ["tyrosine breakdown", "tyrosine degradation", "tyrosine catabolism"], "types": ["T044"], "canonical_name": "tyrosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156679", "aliases": ["tyrosine breakdown to fumarate", "tyrosine degradation to fumarate"], "types": ["T044"], "canonical_name": "tyrosine catabolic process to fumarate", "definition": "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate. [GOC:go_curators]"}
{"concept_id": "C1156681", "aliases": ["aspartate family amino acid catabolism", "aspartate family amino acid breakdown", "aspartate family amino acid degradation"], "types": ["T044"], "canonical_name": "aspartate family amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. [GOC:ai]"}
{"concept_id": "C1156682", "aliases": ["asparagine breakdown", "asparagine degradation", "asparagine catabolism"], "types": ["T044"], "canonical_name": "asparagine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156683", "aliases": ["aspartate catabolism", "aspartate degradation", "aspartate breakdown"], "types": ["T044"], "canonical_name": "aspartate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156684", "aliases": [], "types": ["T044"], "canonical_name": "aspartate transamidation", "definition": "The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156685", "aliases": ["lysine degradation", "lysine catabolic process", "lysine catabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. [GOC:go_curators]", "canonical_name": "lysine breakdown"}
{"concept_id": "C1156686", "aliases": ["D-lysine catabolism", "D-lysine breakdown", "D-lysine degradation"], "types": ["T044"], "canonical_name": "D-lysine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1156687", "aliases": ["L-lysine breakdown", "L-lysine degradation", "L-lysine catabolism"], "types": ["T044"], "canonical_name": "L-lysine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid. [GOC:go_curators, GOC:jsg, GOC:mah]"}
{"concept_id": "C1156688", "aliases": ["lysine fermentation", "L-lysine breakdown to acetate", "L-lysine degradation to acetate"], "types": ["T044"], "canonical_name": "L-lysine catabolic process to acetate", "definition": "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate. [GOC:go_curators]"}
{"concept_id": "C1156689", "aliases": ["L-lysine breakdown to acetyl-CoA", "L-lysine degradation to acetyl-CoA"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA. [GOC:go_curators]", "canonical_name": "L-lysine catabolic process to acetyl-CoA"}
{"concept_id": "C1156690", "aliases": ["L-lysine degradation to glutarate, by acetylation", "L-lysine breakdown to glutarate, by acetylation"], "types": ["T044"], "canonical_name": "L-lysine catabolic process to glutarate, by acetylation", "definition": "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation. [GOC:go_curators]"}
{"concept_id": "C1156691", "aliases": ["methionine breakdown", "methionine degradation", "methionine catabolism"], "types": ["T044"], "canonical_name": "methionine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156692", "aliases": ["methionine breakdown to succinyl-CoA", "methionine degradation to succinyl-CoA"], "types": ["T044"], "canonical_name": "methionine catabolic process to succinyl-CoA", "definition": "The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA. [GOC:go_curators]"}
{"concept_id": "C1156693", "aliases": ["methionine degradation via 2-oxobutanoate", "methionine breakdown via 2-oxobutanoate"], "types": ["T044"], "canonical_name": "methionine catabolic process via 2-oxobutanoate", "definition": "The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate. [GOC:go_curators]"}
{"concept_id": "C1156694", "aliases": ["threonine breakdown", "threonine catabolism", "threonine degradation"], "types": ["T044"], "canonical_name": "threonine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156695", "aliases": [], "types": ["T044"], "canonical_name": "threonine catabolic process to D-lactate"}
{"concept_id": "C1156697", "aliases": ["branched chain family amino acid breakdown", "branched chain family amino acid catabolic process", "branched chain family amino acid catabolism", "branched chain family amino acid degradation"], "types": ["T044"], "canonical_name": "branched-chain amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. [GOC:ai]"}
{"concept_id": "C1156698", "aliases": ["isoleucine breakdown", "isoleucine degradation", "isoleucine catabolism"], "types": ["T044"], "canonical_name": "isoleucine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. [GOC:ai]"}
{"concept_id": "C1156699", "aliases": ["leucine degradation", "leucine breakdown", "leucine catabolism"], "types": ["T044"], "canonical_name": "leucine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid. [GOC:ai]"}
{"concept_id": "C1156700", "aliases": ["valine degradation", "valine breakdown", "valine catabolism"], "types": ["T044"], "canonical_name": "valine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid. [GOC:ai]"}
{"concept_id": "C1156701", "aliases": ["D-amino acid catabolism", "D-amino acid breakdown", "D-amino acid degradation"], "types": ["T044"], "canonical_name": "D-amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids. [GOC:ai, GOC:jsg]"}
{"concept_id": "C1156702", "aliases": ["D-cysteine degradation", "D-cysteine breakdown", "D-cysteine catabolism"], "types": ["T044"], "canonical_name": "D-cysteine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin. [PMID:11527960]"}
{"concept_id": "C1156703", "aliases": ["glutamine family amino acid breakdown", "glutamine family amino acid degradation", "glutamine family amino acid catabolism"], "types": ["T044"], "canonical_name": "glutamine family amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. [GOC:ai]"}
{"concept_id": "C1156704", "aliases": ["arginine degradation", "arginine catabolism", "arginine breakdown"], "types": ["T044"], "canonical_name": "arginine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156705", "aliases": ["arginine breakdown to glutamate", "arginine degradation to glutamate"], "types": ["T044"], "canonical_name": "arginine catabolic process to glutamate", "definition": "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate. [GOC:go_curators]"}
{"concept_id": "C1156706", "aliases": ["arginine degradation to ornithine", "arginine breakdown to ornithine"], "types": ["T044"], "canonical_name": "arginine catabolic process to ornithine", "definition": "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine. [GOC:go_curators]"}
{"concept_id": "C1156707", "aliases": ["arginine breakdown to proline", "arginine degradation to proline"], "types": ["T044"], "canonical_name": "arginine catabolic process to proline", "definition": "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline. [GOC:go_curators]"}
{"concept_id": "C1156708", "aliases": ["arginine breakdown to spermine", "arginine degradation to spermine"], "types": ["T044"], "canonical_name": "arginine catabolic process to spermine", "definition": "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine. [GOC:go_curators]"}
{"concept_id": "C1156709", "aliases": ["arginine degradation to succinate", "arginine breakdown to succinate"], "types": ["T044"], "canonical_name": "arginine catabolic process to succinate", "definition": "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate. [GOC:go_curators]"}
{"concept_id": "C1156710", "aliases": [], "types": ["T044"], "canonical_name": "arginine deiminase pathway", "definition": "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase. [GOC:mah, MetaCyc:ARGDEGRAD-PWY]"}
{"concept_id": "C1156711", "aliases": ["glutamic acid catabolic process", "glutamic acid catabolism", "glutamate degradation", "glutamate breakdown", "glutamate catabolism"], "types": ["T044"], "canonical_name": "glutamate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid. [GOC:go_curators]"}
{"concept_id": "C1156712", "aliases": ["glutamate breakdown to 2-oxoglutarate", "glutamate catabolism to alpha-ketoglutarate", "glutamate catabolism to alpha-oxoglutarate", "glutamate catabolic process to alpha-oxoglutarate", "glutamate catabolism to 2-ketoglutarate", "glutamate catabolic process to alpha-ketoglutarate", "glutamate catabolic process to 2-ketoglutarate", "glutamate degradation to 2-oxoglutarate"], "types": ["T044"], "canonical_name": "glutamate catabolic process to 2-oxoglutarate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate. [GOC:go_curators]"}
{"concept_id": "C1156713", "aliases": ["glutamate degradation to aspartate", "glutamate breakdown to aspartate"], "types": ["T044"], "canonical_name": "glutamate catabolic process to aspartate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate. [GOC:go_curators]"}
{"concept_id": "C1156714", "aliases": [], "types": ["T044"], "canonical_name": "glutamate catabolic process to fumarate"}
{"concept_id": "C1156715", "aliases": [], "types": ["T044"], "canonical_name": "glutamate catabolic process to fumarate, using glutamate synthase (NADPH)"}
{"concept_id": "C1156716", "aliases": [], "types": ["T044"], "canonical_name": "glutamate catabolic process to fumarate, using glutaminase"}
{"concept_id": "C1156717", "aliases": ["glutamate degradation to ornithine", "glutamate breakdown to ornithine"], "types": ["T044"], "canonical_name": "glutamate catabolic process to ornithine", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine. [GOC:go_curators]"}
{"concept_id": "C1156718", "aliases": ["glutamate breakdown to oxaloacetate", "glutamate degradation to oxaloacetate"], "types": ["T044"], "canonical_name": "glutamate catabolic process to oxaloacetate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate. [GOC:go_curators]"}
{"concept_id": "C1156719", "aliases": ["glutamate degradation to succinate"], "types": ["T044"], "canonical_name": "glutamate breakdown to succinate"}
{"concept_id": "C1156720", "aliases": ["glutamate catabolic process via alpha-ketoglutarate", "glutamate catabolic process via alpha-oxoglutarate", "glutamate catabolism via 2-ketoglutarate", "glutamate catabolic process via 2-ketoglutarate", "glutamate catabolism via alpha-ketoglutarate", "glutamate breakdown via 2-oxoglutarate", "glutamate catabolism via alpha-oxoglutarate", "glutamate degradation via 2-oxoglutarate"], "types": ["T044"], "canonical_name": "glutamate catabolic process via 2-oxoglutarate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate. [GOC:go_curators]"}
{"concept_id": "C1156721", "aliases": ["glutamate breakdown via L-citramalate", "glutamate degradation via L-citramalate"], "types": ["T044"], "canonical_name": "glutamate catabolic process via L-citramalate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate. [GOC:go_curators]"}
{"concept_id": "C1156722", "aliases": [], "types": ["T044"], "canonical_name": "glutamate deamidation"}
{"concept_id": "C1156723", "aliases": ["GABA shunt", "gamma-aminobutyrate shunt", "degradation of glutamate to succinate through GABA", "4-aminobutyrate shunt", "glutamate degradation via 4-aminobutyrate", "glutamate degradation via GABA"], "types": ["T044"], "canonical_name": "glutamate decarboxylation to succinate", "definition": "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes. [PMID:12740438]"}
{"concept_id": "C1156724", "aliases": ["glutamate fermentation"], "types": ["T044"], "canonical_name": "anaerobic glutamate catabolic process", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP. [GOC:jl]"}
{"concept_id": "C1156725", "aliases": ["glutamate fermentation via 2-hydroxyglutarate"], "types": ["T044"], "canonical_name": "glutamate catabolic process via 2-hydroxyglutarate", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP. [MetaCyc:P162-PWY]"}
{"concept_id": "C1156726", "aliases": ["glutamate fermentation via mesaconate and citramalate"], "types": ["T044"], "canonical_name": "glutamate catabolic process via mesaconate and citramalate", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP. [MetaCyc:GLUDEG-II-PWY]"}
{"concept_id": "C1156727", "aliases": ["glutamine breakdown", "glutamine degradation", "glutamine catabolism"], "types": ["T044"], "canonical_name": "glutamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid. [GOC:ai]"}
{"concept_id": "C1156728", "aliases": ["proline degradation", "proline breakdown", "proline catabolism"], "types": ["T044"], "canonical_name": "proline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156729", "aliases": ["proline catabolic process to alpha-oxoglutarate", "proline catabolism to alpha-oxoglutarate", "proline degradation to 2-oxoglutarate", "proline catabolism to 2-ketoglutarate", "proline breakdown to 2-oxoglutarate", "proline catabolic process to alpha-ketoglutarate", "proline catabolism to alpha-ketoglutarate", "proline catabolic process to 2-ketoglutarate"], "types": ["T044"], "canonical_name": "proline catabolic process to 2-oxoglutarate", "definition": "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate. [GOC:go_curators]"}
{"concept_id": "C1156731", "aliases": ["histidine breakdown", "histidine catabolism", "histidine degradation"], "types": ["T044"], "canonical_name": "histidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156732", "aliases": ["histidine catabolic process to alpha-ketoglutarate", "histidine catabolism to alpha-oxoglutarate", "histidine catabolic process to alpha-oxoglutarate", "histidine catabolism to 2-ketoglutarate", "histidine breakdown to 2-oxoglutarate", "histidine catabolic process to 2-ketoglutarate", "histidine degradation to 2-oxoglutarate", "histidine catabolism to alpha-ketoglutarate"], "types": ["T044"], "canonical_name": "histidine catabolic process to 2-oxoglutarate", "definition": "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate. [GOC:go_curators]"}
{"concept_id": "C1156733", "aliases": ["histidine breakdown to glutamate and formamide", "histidine degradation to glutamate and formamide"], "types": ["T044"], "canonical_name": "histidine catabolic process to glutamate and formamide", "definition": "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide. [GOC:go_curators]"}
{"concept_id": "C1156734", "aliases": ["histidine degradation to glutamate and formate", "histidine breakdown to glutamate and formate"], "types": ["T044"], "canonical_name": "histidine catabolic process to glutamate and formate", "definition": "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate. [GOC:go_curators]"}
{"concept_id": "C1156735", "aliases": ["histidine breakdown to hydantoin-5-propionate", "histidine degradation to hydantoin-5-propionate"], "types": ["T044"], "canonical_name": "histidine catabolic process to hydantoin-5-propionate", "definition": "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate. [GOC:go_curators]"}
{"concept_id": "C1156736", "aliases": ["histidine breakdown to imidazol-5-yl-lactate", "histidine degradation to imidazol-5-yl-lactate"], "types": ["T044"], "canonical_name": "histidine catabolic process to imidazol-5-yl-lactate", "definition": "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate. [GOC:go_curators]"}
{"concept_id": "C1156738", "aliases": ["beta-alanine degradation", "beta-alanine breakdown", "beta-alanine catabolism"], "types": ["T044"], "canonical_name": "beta-alanine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156739", "aliases": ["beta-alanine degradation to L-alanine", "beta-alanine breakdown to L-alanine"], "types": ["T044"], "canonical_name": "beta-alanine catabolic process to L-alanine", "definition": "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine. [GOC:go_curators]"}
{"concept_id": "C1156740", "aliases": ["beta-alanine degradation to mevalonate semialdehyde, by transamination", "beta-alanine breakdown to mevalonate semialdehyde, by transamination"], "types": ["T044"], "canonical_name": "beta-alanine catabolic process to mevalonate semialdehyde, by transamination", "definition": "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination. [GOC:go_curators]"}
{"concept_id": "C1156741", "aliases": ["ornithine breakdown", "ornithine catabolism", "ornithine degradation"], "types": ["T044"], "canonical_name": "ornithine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156742", "aliases": ["ornithine breakdown via proline", "ornithine degradation via proline"], "types": ["T044"], "canonical_name": "ornithine catabolic process via proline", "definition": "The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline. [GOC:go_curators]"}
{"concept_id": "C1156743", "aliases": ["ornithine breakdown, by decarboxylation", "ornithine degradation, by decarboxylation"], "types": ["T044"], "canonical_name": "ornithine catabolic process, by decarboxylation", "definition": "The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation. [GOC:go_curators]"}
{"concept_id": "C1156744", "aliases": ["pyruvate family amino acid catabolism", "pyruvate family amino acid breakdown", "pyruvate family amino acid degradation"], "types": ["T044"], "canonical_name": "pyruvate family amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine. [GOC:jl]"}
{"concept_id": "C1156745", "aliases": ["alanine breakdown", "alanine degradation", "alanine catabolism"], "types": ["T044"], "canonical_name": "alanine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156750", "aliases": ["D-alanine family amino acid catabolism", "D-alanine family amino acid degradation", "D-alanine family amino acid breakdown"], "types": ["T044"], "canonical_name": "D-alanine family amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids. [GOC:mah]"}
{"concept_id": "C1156751", "aliases": ["serine family amino acid catabolism", "serine family amino acid breakdown", "serine family amino acid degradation"], "types": ["T044"], "canonical_name": "serine family amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. [GOC:ai]"}
{"concept_id": "C1156752", "aliases": ["cysteine degradation", "cysteine breakdown", "cysteine catabolism"], "types": ["T044"], "canonical_name": "cysteine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156753", "aliases": ["L-cysteine catabolism", "L-cysteine breakdown", "L-cysteine degradation"], "types": ["T040"], "canonical_name": "L-cysteine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid. [GOC:jsg, GOC:mah]"}
{"concept_id": "C1156754", "aliases": ["L-cysteine degradation to hypotaurine", "L-cysteine breakdown to hypotaurine"], "types": ["T044"], "canonical_name": "L-cysteine catabolic process to hypotaurine", "definition": "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine. [GOC:go_curators]"}
{"concept_id": "C1156755", "aliases": ["L-cysteine degradation to pyruvate", "L-cysteine breakdown to pyruvate"], "types": ["T044"], "canonical_name": "L-cysteine catabolic process to pyruvate", "definition": "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate. [GOC:go_curators]"}
{"concept_id": "C1156756", "aliases": ["L-cysteine breakdown to pyruvate, using cysteine dioxygenase", "L-cysteine degradation to pyruvate, using cysteine dioxygenase"], "types": ["T044"], "canonical_name": "L-cysteine catabolic process to pyruvate, using cysteine dioxygenase", "definition": "The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20). [GOC:jl]"}
{"concept_id": "C1156757", "aliases": ["L-cysteine degradation to taurine", "L-cysteine breakdown to taurine"], "types": ["T044"], "canonical_name": "L-cysteine catabolic process to taurine", "definition": "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine. [GOC:go_curators]"}
{"concept_id": "C1156758", "aliases": ["L-cysteine degradation via cystine", "L-cysteine breakdown via cystine"], "types": ["T040"], "canonical_name": "L-cysteine catabolic process via cystine", "definition": "The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine. [GOC:go_curators]"}
{"concept_id": "C1156759", "aliases": ["L-cysteine degradation via cystine, using cysteine transaminase", "L-cysteine breakdown via cystine, using cysteine transaminase"], "types": ["T044"], "canonical_name": "L-cysteine catabolic process via cystine, using cysteine transaminase", "definition": "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase. [GOC:jl]"}
{"concept_id": "C1156760", "aliases": ["L-cysteine degradation via cystine, using cystine reductase", "L-cysteine breakdown via cystine, using cystine reductase"], "types": ["T044"], "canonical_name": "L-cysteine catabolic process via cystine, using cystine reductase", "definition": "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase. [GOC:jl]"}
{"concept_id": "C1156761", "aliases": ["L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase", "L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase"], "types": ["T044"], "canonical_name": "L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase", "definition": "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase. [GOC:jl]"}
{"concept_id": "C1156762", "aliases": ["glycine breakdown", "glycine degradation", "glycine catabolism"], "types": ["T044"], "canonical_name": "glycine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156763", "aliases": ["glycine breakdown to creatine", "glycine degradation to creatine"], "types": ["T044"], "canonical_name": "glycine catabolic process to creatine", "definition": "The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine. [GOC:go_curators]"}
{"concept_id": "C1156764", "aliases": [], "types": ["T044"], "canonical_name": "glycine decarboxylation via glycine cleavage system", "definition": "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex. [MetaCyc:GLYCLEAV-PWY]"}
{"concept_id": "C1156765", "aliases": ["glycine fermentation"], "types": ["T044"], "canonical_name": "anaerobic glycine catabolic process", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP. [GOC:jl]"}
{"concept_id": "C1156766", "aliases": ["homoserine degradation", "homoserine breakdown", "homoserine catabolism"], "types": ["T044"], "canonical_name": "homoserine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156767", "aliases": ["selenocysteine breakdown", "selenocysteine degradation", "selenocysteine catabolism"], "types": ["T044"], "canonical_name": "selenocysteine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156769", "aliases": ["sulfur amino acid catabolism", "sulphur amino acid catabolism", "sulphur amino acid catabolic process", "sulfur amino acid degradation", "sulfur amino acid breakdown"], "types": ["T044"], "canonical_name": "sulfur amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. [GOC:ai]"}
{"concept_id": "C1156770", "aliases": ["S-adenosylhomocysteine catabolism", "S-adenosylhomocysteine breakdown", "S-adenosylhomocysteine degradation"], "types": ["T044"], "canonical_name": "S-adenosylhomocysteine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine. [ISBN:0198506732]"}
{"concept_id": "C1156771", "aliases": ["biogenic amine breakdown", "biogenic amine catabolism", "biogenic amine degradation"], "types": ["T044"], "canonical_name": "cellular biogenic amine catabolic process", "definition": "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. [GOC:go_curators, GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156772", "aliases": ["betaine degradation", "betaine breakdown", "betaine catabolic process", "betaine catabolism"], "types": ["T044"], "canonical_name": "amino-acid betaine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156773", "aliases": ["vitamin Bt catabolic process", "carnitine breakdown", "vitamin Bt catabolism", "carnitine degradation", "carnitine catabolism"], "types": ["T044"], "canonical_name": "carnitine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156774", "aliases": ["choline breakdown", "choline catabolism", "choline degradation"], "types": ["T044"], "canonical_name": "choline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156775", "aliases": ["indolalkylamine breakdown", "indolalkylamine degradation", "indolalkylamine catabolism"], "types": ["T044"], "canonical_name": "indolalkylamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. [GOC:curators]"}
{"concept_id": "C1156776", "aliases": ["melatonin breakdown", "melatonin degradation", "melatonin catabolism"], "types": ["T044"], "canonical_name": "melatonin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine). [GOC:jl]"}
{"concept_id": "C1156777", "aliases": ["nicotianamine degradation", "nicotianamine breakdown", "nicotianamine catabolism"], "types": ["T044"], "canonical_name": "nicotianamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. [GOC:mah, PMID:10069850]"}
{"concept_id": "C1156778", "aliases": ["polyamine catabolism", "polyamine degradation", "polyamine breakdown"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]", "canonical_name": "polyamine catabolic process"}
{"concept_id": "C1156779", "aliases": ["putrescine breakdown", "putrescine degradation", "putrescine catabolism"], "types": ["T044"], "canonical_name": "putrescine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. [GOC:ai]"}
{"concept_id": "C1156780", "aliases": ["spermidine breakdown", "spermidine degradation", "spermidine catabolism"], "types": ["T044"], "canonical_name": "spermidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]"}
{"concept_id": "C1156781", "aliases": ["nor-spermidine breakdown", "nor-spermidine degradation", "nor-spermidine catabolism"], "types": ["T044"], "canonical_name": "nor-spermidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]"}
{"concept_id": "C1156782", "aliases": ["trypanothione degradation", "trypanothione breakdown", "trypanothione catabolism"], "types": ["T044"], "canonical_name": "trypanothione catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress. [GOC:ai]"}
{"concept_id": "C1156783", "aliases": ["spermine breakdown", "spermine catabolism", "spermine degradation"], "types": ["T044"], "canonical_name": "spermine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. [PMID:12141946]"}
{"concept_id": "C1156784", "aliases": ["thyroid hormone breakdown", "thyroid hormone catabolism", "thyroid hormone degradation"], "types": ["T044"], "canonical_name": "thyroid hormone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156785", "aliases": ["aromatic amino acid family metabolism"], "types": ["T044"], "canonical_name": "aromatic amino acid family metabolic process", "definition": "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). [GOC:go_curators]"}
{"concept_id": "C1156787", "aliases": ["tryptophan metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [ISBN:0198547684]", "canonical_name": "tryptophan metabolism"}
{"concept_id": "C1156788", "aliases": ["indoleacetic acid formation via tryptophan", "indoleacetic acid synthesis via tryptophan", "IAA biosynthetic process via tryptophan", "indoleacetic acid anabolism via tryptophan"], "types": ["T044"], "canonical_name": "indoleacetic acid biosynthetic process via tryptophan", "definition": "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan. [GOC:lm, GOC:lr, PMID:10375566]"}
{"concept_id": "C1156789", "aliases": ["nicotinate nucleotide formation from tryptophan", "nicotinate nucleotide synthesis from tryptophan", "nicotinate nucleotide anabolism from tryptophan"], "types": ["T044"], "canonical_name": "nicotinate nucleotide biosynthetic process from tryptophan", "definition": "The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan. [GOC:go_curators]"}
{"concept_id": "C1156790", "aliases": ["tyrosine metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. [GOC:go_curators]", "canonical_name": "tyrosine metabolism"}
{"concept_id": "C1156791", "aliases": ["melanin synthesis from tyrosine", "melanin anabolism from tyrosine", "melanin formation from tyrosine"], "types": ["T044"], "canonical_name": "melanin biosynthetic process from tyrosine", "definition": "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine. [GOC:go_curators]"}
{"concept_id": "C1156792", "aliases": ["aspartate family amino acid metabolism"], "types": ["T044"], "canonical_name": "aspartate family amino acid metabolic process", "definition": "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. [GOC:ai]"}
{"concept_id": "C1156793", "aliases": ["asparagine metabolism"], "types": ["T044"], "canonical_name": "asparagine metabolic process", "definition": "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156794", "aliases": ["(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine", "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine", "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine"], "types": ["T044"], "canonical_name": "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine", "definition": "The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7. [RESID:AA0328]"}
{"concept_id": "C1156795", "aliases": [], "types": ["T044"], "canonical_name": "cyclization of asparagine, during protein splicing"}
{"concept_id": "C1156796", "aliases": ["aspartate metabolism"], "types": ["T044"], "canonical_name": "aspartate metabolic process", "definition": "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156798", "aliases": ["lysine metabolism"], "types": ["T044"], "canonical_name": "lysine metabolic process", "definition": "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156799", "aliases": ["D-lysine metabolism"], "types": ["T044"], "canonical_name": "D-lysine metabolic process", "definition": "The chemical reactions and pathways involving D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1156800", "aliases": ["L-lysine metabolism"], "types": ["T044"], "canonical_name": "L-lysine metabolic process", "definition": "The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1156801", "aliases": ["methionine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]", "canonical_name": "methionine metabolic process"}
{"concept_id": "C1156802", "aliases": ["threonine metabolism"], "types": ["T044"], "canonical_name": "threonine metabolic process", "definition": "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156803", "aliases": ["branched chain family amino acid metabolism"], "types": ["T044"], "canonical_name": "branched-chain amino acid metabolic process", "definition": "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. [GOC:ai]"}
{"concept_id": "C1156804", "aliases": ["isoleucine metabolism"], "types": ["T044"], "canonical_name": "isoleucine metabolic process", "definition": "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. [GOC:ai]"}
{"concept_id": "C1156805", "aliases": ["leucine metabolism"], "types": ["T044"], "canonical_name": "leucine metabolic process", "definition": "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid. [GOC:ai]"}
{"concept_id": "C1156806", "aliases": ["valine metabolism"], "types": ["T044"], "canonical_name": "valine metabolic process", "definition": "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. [GOC:ai]"}
{"concept_id": "C1156807", "aliases": ["D-amino acid metabolism"], "types": ["T044"], "canonical_name": "D-amino acid metabolic process", "definition": "The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids. [GOC:ai, GOC:jsg]"}
{"concept_id": "C1156808", "aliases": ["D-alanine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid. [GOC:ai, GOC:jsg]", "canonical_name": "D-alanine metabolic process"}
{"concept_id": "C1156809", "aliases": ["glutamine family amino acid metabolism"], "types": ["T044"], "canonical_name": "glutamine family amino acid metabolic process", "definition": "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. [GOC:ai]"}
{"concept_id": "C1156810", "aliases": ["arginine metabolism"], "types": ["T044"], "canonical_name": "arginine metabolic process", "definition": "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156811", "aliases": ["glutamate metabolism", "glutamate metabolic process", "glutamic acid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. [GOC:go_curators]", "canonical_name": "glutamic acid metabolic process"}
{"concept_id": "C1156812", "aliases": ["glutamate metabolic process via glutamine and ammonia", "glutamate metabolism via glutamine and ammonia"], "types": ["T044"], "canonical_name": "ammonia assimilation cycle", "definition": "The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen. [MetaCyc:AMMASSIM-PWY]"}
{"concept_id": "C1156813", "aliases": ["protoporphyrinogen IX formation from glutamate", "protoporphyrinogen IX anabolism from glutamate", "protoporphyrinogen IX synthesis from glutamate"], "types": ["T044"], "canonical_name": "protoporphyrinogen IX biosynthetic process from glutamate", "definition": "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate. [GOC:go_curators]"}
{"concept_id": "C1156814", "aliases": ["glutamine metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. [GOC:ai]", "canonical_name": "glutamine metabolism"}
{"concept_id": "C1156815", "aliases": [], "types": ["T044"], "canonical_name": "cyclization of glutamine, during protein splicing"}
{"concept_id": "C1156816", "aliases": ["peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine", "peptidyl-L-glutamic acid 5-methyl ester formation from glutamine", "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine"], "types": ["T044"], "canonical_name": "peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine", "definition": "The coupled methyl esterification and deamidation of peptidyl-glutamine. [RESID:AA0072]"}
{"concept_id": "C1156817", "aliases": ["proline metabolism"], "types": ["T044"], "canonical_name": "proline metabolic process", "definition": "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156818", "aliases": ["nopaline breakdown to proline", "nopaline degradation to proline"], "types": ["T044"], "canonical_name": "nopaline catabolic process to proline", "definition": "The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline. [GOC:go_curators]"}
{"concept_id": "C1156819", "aliases": ["octopine breakdown to proline", "octopine degradation to proline"], "types": ["T044"], "canonical_name": "octopine catabolic process to proline", "definition": "The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline. [GOC:go_curators]"}
{"concept_id": "C1156820", "aliases": ["proline cycling"], "types": ["T044"], "canonical_name": "proline salvage", "definition": "Any process which produces the amino acid proline from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1156821", "aliases": [], "types": ["T044"], "canonical_name": "proline oxidation"}
{"concept_id": "C1156823", "aliases": ["histidine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:go_curators]", "canonical_name": "histidine metabolic process"}
{"concept_id": "C1156825", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-L-amino acid racemization", "definition": "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid. [GOC:ma]"}
{"concept_id": "C1156826", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-asparagine racemization", "definition": "The racemization of peptidyl-asparagine. [RESID:AA0196]"}
{"concept_id": "C1156827", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-D-alanine racemization", "definition": "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine. [RESID:AA0191]"}
{"concept_id": "C1156828", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-D-alanine racemization via peptidyl-L-serine", "definition": "The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine. [RESID:AA0191]"}
{"concept_id": "C1156829", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-D-alanine racemization, direct", "definition": "The racemization of peptidyl-alanine. [RESID:AA0191]"}
{"concept_id": "C1156830", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-isoleucine racemization", "definition": "The racemization of peptidyl-isoleucine. [RESID:AA0192]"}
{"concept_id": "C1156831", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-leucine racemization", "definition": "The racemization of peptidyl-leucine. [RESID:AA0197]"}
{"concept_id": "C1156832", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-methionine racemization", "definition": "The racemization of peptidyl-methionine. [RESID:AA0193]"}
{"concept_id": "C1156833", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-phenylalanine racemization", "definition": "The racemization of peptidyl-phenylalanine. [RESID:AA0194]"}
{"concept_id": "C1156834", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine racemization", "definition": "The racemization of peptidyl-serine. [RESID:AA0195]"}
{"concept_id": "C1156835", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tryptophan racemization", "definition": "The racemization of peptidyl-tryptophan. [RESID:AA0198]"}
{"concept_id": "C1156837", "aliases": ["beta-alanine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. [GOC:jl, ISBN:0198506732]", "canonical_name": "beta-alanine metabolic process"}
{"concept_id": "C1156838", "aliases": ["citrulline metabolism"], "types": ["T044"], "canonical_name": "citrulline metabolic process", "definition": "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. [ISBN:0198506732]"}
{"concept_id": "C1156839", "aliases": ["citrulline synthesis", "citrulline anabolism", "citrulline formation", "citrulline biosynthesis"], "types": ["T044"], "canonical_name": "citrulline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. [ISBN:0198506732]"}
{"concept_id": "C1156841", "aliases": ["citrulline degradation", "citrulline breakdown", "citrulline catabolism"], "types": ["T044"], "canonical_name": "citrulline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. [ISBN:0198506732]"}
{"concept_id": "C1156842", "aliases": ["ornithine metabolism"], "types": ["T044"], "canonical_name": "ornithine metabolic process", "definition": "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156843", "aliases": ["pyruvate family amino acid metabolism"], "types": ["T044"], "canonical_name": "pyruvate family amino acid metabolic process", "definition": "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine. [GOC:jl]"}
{"concept_id": "C1156844", "aliases": ["alanine metabolism"], "types": ["T044"], "canonical_name": "alanine metabolic process", "definition": "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156845", "aliases": ["D-alanine family amino acid metabolism"], "types": ["T044"], "canonical_name": "D-alanine family amino acid metabolic process", "definition": "The chemical reactions and pathways involving D-alanine and related amino acids. [GOC:ai]"}
{"concept_id": "C1156846", "aliases": ["regulation of amino acid metabolism"], "types": ["T044"], "canonical_name": "regulation of cellular amino acid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. [GOC:go_curators]"}
{"concept_id": "C1156849", "aliases": ["serine family amino acid metabolism"], "types": ["T044"], "canonical_name": "serine family amino acid metabolic process", "definition": "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. [GOC:ai]"}
{"concept_id": "C1156850", "aliases": ["cysteine metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators]", "canonical_name": "cysteine metabolism"}
{"concept_id": "C1156851", "aliases": ["D-cysteine metabolism"], "types": ["T044"], "canonical_name": "D-cysteine metabolic process", "definition": "The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin. [GOC:ai]"}
{"concept_id": "C1156852", "aliases": ["L-cysteine metabolism"], "types": ["T044"], "canonical_name": "L-cysteine metabolic process", "definition": "The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1156853", "aliases": ["transsulphuration"], "types": ["T044"], "canonical_name": "transsulfuration", "definition": "The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. [MetaCyc:PWY-801]"}
{"concept_id": "C1156854", "aliases": ["glycine metabolism"], "types": ["T044"], "canonical_name": "glycine metabolic process", "definition": "The chemical reactions and pathways involving glycine, aminoethanoic acid. [GOC:go_curators]"}
{"concept_id": "C1156855", "aliases": ["protoporphyrinogen IX synthesis from glycine", "protoporphyrinogen IX formation from glycine", "protoporphyrinogen IX anabolism from glycine"], "types": ["T044"], "canonical_name": "protoporphyrinogen IX biosynthetic process from glycine", "definition": "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine. [GOC:go_curators]"}
{"concept_id": "C1156856", "aliases": ["homoserine metabolism"], "types": ["T044"], "canonical_name": "homoserine metabolic process", "definition": "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156857", "aliases": ["selenocysteine metabolism"], "types": ["T044"], "canonical_name": "selenocysteine metabolic process", "definition": "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1156859", "aliases": ["sulphur amino acid metabolic process", "sulphur amino acid metabolism", "sulfur amino acid metabolism"], "types": ["T044"], "canonical_name": "sulfur amino acid metabolic process", "definition": "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. [GOC:ai]"}
{"concept_id": "C1156860", "aliases": ["protein amino acid sulfation", "protein amino acid sulphation"], "types": ["T044"], "canonical_name": "protein sulfation", "definition": "The addition of a sulfate group as an ester to a protein amino acid. [GOC:curators]"}
{"concept_id": "C1156861", "aliases": ["peptidyl-tyrosine sulphation"], "types": ["T044"], "canonical_name": "peptidyl-tyrosine sulfation", "definition": "The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine. [RESID:AA0172]"}
{"concept_id": "C1156862", "aliases": ["aminosaccharide metabolic process", "aminosaccharide metabolism", "amino sugar metabolism"], "types": ["T044"], "canonical_name": "amino sugar metabolic process", "definition": "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156863", "aliases": ["amino sugar formation", "amino sugar anabolism", "amino sugar biosynthesis", "amino sugar synthesis", "aminosaccharide biosynthetic process", "aminosaccharide biosynthesis"], "types": ["T044"], "canonical_name": "amino sugar biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. [GOC:curators]"}
{"concept_id": "C1156864", "aliases": ["fructosamine formation", "fructosamine biosynthesis", "fructosamine anabolism", "fructosamine synthesis"], "types": ["T044"], "canonical_name": "fructosamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156865", "aliases": ["glucosamine formation", "glucosamine anabolism", "glucosamine biosynthesis", "glucosamine synthesis", "chitosamine biosynthetic process", "chitosamine biosynthesis"], "types": ["T044"], "canonical_name": "glucosamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156866", "aliases": ["N-acetylglucosamine synthesis", "N-acetylglucosamine biosynthesis", "N-acetylglucosamine anabolism", "N-acetylglucosamine formation"], "types": ["T044"], "canonical_name": "N-acetylglucosamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. [ISBN:0198506732]"}
{"concept_id": "C1156867", "aliases": ["UDP-GlcNAc biosynthesis", "UDP-N-acetylglucosamine synthesis", "UDP-GlcNAc biosynthetic process", "UDP-N-acetylglucosamine formation", "UDP-N-acetylglucosamine anabolism", "UDP-N-acetylglucosamine biosynthesis"], "types": ["T044"], "canonical_name": "UDP-N-acetylglucosamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1156868", "aliases": ["mannosamine synthesis", "mannosamine biosynthesis", "mannosamine formation", "mannosamine anabolism"], "types": ["T044"], "canonical_name": "mannosamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. [GOC:curators]"}
{"concept_id": "C1156869", "aliases": ["N-acetylmannosamine formation", "N-acetylmannosamine biosynthesis", "N-acetylmannosamine synthesis", "N-acetylmannosamine anabolism"], "types": ["T044"], "canonical_name": "N-acetylmannosamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156870", "aliases": ["N-acetylneuraminate biosynthesis", "N-acetylneuraminate synthesis", "N-acetylneuraminate anabolism", "N-acetylneuraminate formation"], "types": ["T044"], "canonical_name": "N-acetylneuraminate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. [ISBN:0198506732]"}
{"concept_id": "C1156871", "aliases": ["CMP-N-acetylneuraminate anabolism", "CMP-N-acetylneuraminate biosynthesis", "CMP-N-acetylneuraminate formation", "CMP-N-acetylneuraminate synthesis"], "types": ["T044"], "canonical_name": "CMP-N-acetylneuraminate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate. [GOC:ai]"}
{"concept_id": "C1156872", "aliases": ["UDP-N-acetylgalactosamine synthesis", "UDP-N-acetylgalactosamine anabolism", "UDP-N-acetylgalactosamine formation", "UDP-N-acetylgalactosamine biosynthesis"], "types": ["T044"], "canonical_name": "UDP-N-acetylgalactosamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1156873", "aliases": ["amino sugar degradation", "aminosaccharide catabolism", "amino sugar breakdown", "amino sugar catabolism", "aminosaccharide catabolic process"], "types": ["T044"], "canonical_name": "amino sugar catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. [GOC:curators]"}
{"concept_id": "C1156874", "aliases": ["fructosamine breakdown", "fructosamine degradation", "fructosamine catabolism"], "types": ["T044"], "canonical_name": "fructosamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156875", "aliases": ["glucosamine catabolism", "chitosamine catabolic process", "glucosamine breakdown", "chitosamine catabolism", "glucosamine degradation"], "types": ["T044"], "canonical_name": "glucosamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156876", "aliases": ["N-acetylglucosamine catabolism", "N-acetylglucosamine breakdown", "N-acetylglucosamine degradation"], "types": ["T044"], "canonical_name": "N-acetylglucosamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. [ISBN:0198506732]"}
{"concept_id": "C1156877", "aliases": ["UDP-N-acetylglucosamine catabolism", "UDP-N-acetylglucosamine degradation", "UDP-N-acetylglucosamine breakdown"], "types": ["T044"], "canonical_name": "UDP-N-acetylglucosamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1156878", "aliases": ["mannosamine degradation", "mannosamine breakdown", "mannosamine catabolism"], "types": ["T044"], "canonical_name": "mannosamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. [GOC:curators]"}
{"concept_id": "C1156879", "aliases": ["N-acetylmannosamine catabolism", "N-acetylmannosamine degradation", "N-acetylmannosamine breakdown"], "types": ["T044"], "canonical_name": "N-acetylmannosamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156880", "aliases": ["N-acetylneuraminate degradation", "N-acetylneuraminate catabolism", "N-acetylneuraminate breakdown"], "types": ["T044"], "canonical_name": "N-acetylneuraminate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. [ISBN:0198506732]"}
{"concept_id": "C1156881", "aliases": ["UDP-N-acetylgalactosamine breakdown", "UDP-N-acetylgalactosamine degradation", "UDP-N-acetylgalactosamine catabolism"], "types": ["T044"], "canonical_name": "UDP-N-acetylgalactosamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1156882", "aliases": ["fructosamine metabolism"], "types": ["T044"], "canonical_name": "fructosamine metabolic process", "definition": "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156883", "aliases": ["fructoseglycine metabolism"], "types": ["T044"], "canonical_name": "fructoseglycine metabolic process", "definition": "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group. [GOC:ai]"}
{"concept_id": "C1156884", "aliases": ["fructoselysine metabolism"], "types": ["T044"], "canonical_name": "fructoselysine metabolic process", "definition": "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group. [GOC:ai]"}
{"concept_id": "C1156885", "aliases": ["chitosamine metabolic process", "glucosamine metabolism", "chitosamine metabolism", "glucosamine-containing compound metabolic process", "glucosamines metabolic process", "glucosamine-containing compound metabolism", "glucosamines metabolism"], "types": ["T044"], "canonical_name": "glucosamine metabolic process", "definition": "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156886", "aliases": ["N-acetylglucosamine metabolism"], "types": ["T044"], "canonical_name": "N-acetylglucosamine metabolic process", "definition": "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. [ISBN:0198506732]"}
{"concept_id": "C1156887", "aliases": ["UDP-N-acetylglucosamine metabolism"], "types": ["T044"], "canonical_name": "UDP-N-acetylglucosamine metabolic process", "definition": "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1156888", "aliases": ["mannosamine metabolism"], "types": ["T044"], "canonical_name": "mannosamine metabolic process", "definition": "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. [GOC:curators]"}
{"concept_id": "C1156889", "aliases": ["N-acetylmannosamine metabolism"], "types": ["T044"], "canonical_name": "N-acetylmannosamine metabolic process", "definition": "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156890", "aliases": ["sialic acid metabolic process", "N-acetylneuraminate metabolism", "sialic acid metabolism"], "types": ["T044"], "canonical_name": "N-acetylneuraminate metabolic process", "definition": "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. [ISBN:0198506732]"}
{"concept_id": "C1156891", "aliases": ["CMP-N-acetylneuraminate metabolism"], "types": ["T044"], "canonical_name": "CMP-N-acetylneuraminate metabolic process", "definition": "The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate. [GOC:ai]"}
{"concept_id": "C1156892", "aliases": ["UDP-N-acetylgalactosamine metabolism"], "types": ["T044"], "canonical_name": "UDP-N-acetylgalactosamine metabolic process", "definition": "The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1156893", "aliases": ["GABA metabolism", "4-aminobutanoate metabolism", "GABA metabolic process", "4-aminobutyrate metabolism", "4-aminobutyrate metabolic process", "4-aminobutanoate metabolic process", "gamma-aminobutyric acid metabolism"], "types": ["T044"], "canonical_name": "gamma-aminobutyric acid metabolic process", "definition": "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [ISBN:0198506732]"}
{"concept_id": "C1156896", "aliases": ["aminoglycan metabolism"], "types": ["T044"], "canonical_name": "aminoglycan metabolic process", "definition": "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156897", "aliases": ["aminoglycan biosynthesis", "aminoglycan anabolism", "aminoglycan formation", "aminoglycan synthesis"], "types": ["T044"], "canonical_name": "aminoglycan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156898", "aliases": ["galactosaminoglycan anabolism", "galactosaminoglycan formation", "galactosaminoglycan synthesis", "galactosaminoglycan biosynthesis"], "types": ["T044"], "canonical_name": "galactosaminoglycan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose. [GOC:ai]"}
{"concept_id": "C1156899", "aliases": ["glycosaminoglycan anabolism", "glycosaminoglycan synthesis", "glycosaminoglycan biosynthesis", "glycosaminoglycan formation"], "types": ["T044"], "canonical_name": "glycosaminoglycan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. [ISBN:0192800981]"}
{"concept_id": "C1156900", "aliases": ["chondroitin sulphate biosynthetic process", "chondroitin sulfate synthesis", "chondroitin sulfate anabolism", "chondroitin sulphate biosynthesis", "chondroitin sulfate formation", "chondroitin sulfate biosynthesis"], "types": ["T044"], "canonical_name": "chondroitin sulfate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156901", "aliases": ["dermatan sulfate formation", "dermatan sulphate biosynthetic process", "chondroitin sulfate B biosynthetic process", "chondroitin sulfate B biosynthesis", "dermatan sulfate biosynthesis", "dermatan sulfate anabolism", "dermatan sulphate biosynthesis", "dermatan sulfate synthesis"], "types": ["T044"], "canonical_name": "dermatan sulfate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156902", "aliases": ["heparin biosynthesis", "heparin formation", "heparin anabolism", "heparin synthesis"], "types": ["T044"], "canonical_name": "heparin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156903", "aliases": ["hyaluronan synthesis", "hyaluronan formation", "hyaluronan anabolism", "hyaluronan biosynthesis"], "types": ["T044"], "canonical_name": "hyaluronan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156904", "aliases": ["keratan sulphate biosynthesis", "keratan sulfate anabolism", "keratan sulfate biosynthetic process", "keratan sulfate synthesis", "keratan sulphate biosynthetic process", "keratan sulfate formation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. [ISBN:0198547684, RESID:AA0247]", "canonical_name": "keratan sulfate biosynthesis"}
{"concept_id": "C1156905", "aliases": ["aminoglycan catabolism", "aminoglycan degradation", "aminoglycan breakdown"], "types": ["T044"], "canonical_name": "aminoglycan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156906", "aliases": ["galactosaminoglycan breakdown", "galactosaminoglycan degradation", "galactosaminoglycan catabolism"], "types": ["T044"], "canonical_name": "galactosaminoglycan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose. [GOC:ai]"}
{"concept_id": "C1156907", "aliases": ["glycosaminoglycan catabolism", "glycosaminoglycan degradation", "glycosaminoglycan catabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. [ISBN:0192800981]", "canonical_name": "glycosaminoglycan breakdown"}
{"concept_id": "C1156908", "aliases": ["chondroitin sulfate breakdown", "chondroitin sulfate degradation", "chondroitin sulfate catabolism", "chondroitin sulphate catabolic process", "chondroitin sulphate catabolism"], "types": ["T044"], "canonical_name": "chondroitin sulfate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156909", "aliases": ["chondroitin sulfate B catabolic process", "dermatan sulphate catabolic process", "dermatan sulfate breakdown", "dermatan sulphate catabolism", "dermatan sulfate catabolism", "dermatan sulfate degradation", "chondroitin sulfate B catabolism"], "types": ["T044"], "canonical_name": "dermatan sulfate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156910", "aliases": ["heparin degradation", "heparin catabolism", "heparin breakdown"], "types": ["T044"], "canonical_name": "heparin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156911", "aliases": ["hyaluronan catabolism", "hyaluronan breakdown", "hyaluronan degradation"], "types": ["T044"], "canonical_name": "hyaluronan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156912", "aliases": ["keratan sulphate catabolic process", "keratan sulphate catabolism", "keratan sulfate breakdown", "keratan sulfate catabolism", "keratan sulfate degradation"], "types": ["T044"], "canonical_name": "keratan sulfate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. [GOC:go_curators]"}
{"concept_id": "C1156913", "aliases": ["galactosaminoglycan metabolism"], "types": ["T044"], "canonical_name": "galactosaminoglycan metabolic process", "definition": "The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose. [GOC:ai]"}
{"concept_id": "C1156914", "aliases": ["glycosaminoglycan metabolism"], "types": ["T044"], "canonical_name": "glycosaminoglycan metabolic process", "definition": "The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. [ISBN:0192800981]"}
{"concept_id": "C1156915", "aliases": ["chondroitin sulphate metabolism", "chondroitin sulphate metabolic process", "chondroitin sulfate metabolism"], "types": ["T044"], "canonical_name": "chondroitin sulfate metabolic process", "definition": "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156916", "aliases": ["protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine"], "types": ["T044"], "canonical_name": "protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine", "definition": "Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. [RESID:AA0208]"}
{"concept_id": "C1156917", "aliases": ["peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan"], "types": ["T044"], "canonical_name": "peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan", "definition": "The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain. [PMID:1898736, RESID:AA0219]"}
{"concept_id": "C1156918", "aliases": ["dermatan sulfate metabolism", "dermatan sulphate metabolic process", "dermatan sulphate metabolism", "chondroitin sulfate B metabolic process", "chondroitin sulfate B metabolism"], "types": ["T044"], "canonical_name": "dermatan sulfate metabolic process", "definition": "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156919", "aliases": ["heparin metabolism"], "types": ["T044"], "canonical_name": "heparin metabolic process", "definition": "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156920", "aliases": ["hyaluronan metabolism"], "types": ["T044"], "canonical_name": "hyaluronan metabolic process", "definition": "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156921", "aliases": ["keratan sulphate metabolic process", "keratan sulphate metabolism", "keratan sulfate metabolism"], "types": ["T044"], "canonical_name": "keratan sulfate metabolic process", "definition": "The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. [GOC:go_curators]"}
{"concept_id": "C1156922", "aliases": ["biogenic amine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. [GOC:jl, ISBN:0395825172]", "canonical_name": "cellular biogenic amine metabolic process"}
{"concept_id": "C1156923", "aliases": ["betaine metabolism", "betaine metabolic process"], "types": ["T044"], "canonical_name": "amino-acid betaine metabolic process", "definition": "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156924", "aliases": ["vitamin Bt metabolism", "vitamin Bt metabolic process", "carnitine metabolism"], "types": ["T044"], "canonical_name": "carnitine metabolic process", "definition": "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156925", "aliases": ["carnitine metabolism, CoA-linked"], "types": ["T044"], "canonical_name": "carnitine metabolic process, CoA-linked", "definition": "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA. [GOC:go_curators]"}
{"concept_id": "C1156926", "aliases": ["ethanolamine and derivative metabolic process", "ethanolamine-containing compound metabolism", "ethanolamine and derivative metabolism"], "types": ["T044"], "canonical_name": "ethanolamine-containing compound metabolic process", "definition": "The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. [GOC:mah]"}
{"concept_id": "C1156927", "aliases": ["choline metabolism"], "types": ["T044"], "canonical_name": "choline metabolic process", "definition": "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156928", "aliases": ["indolalkylamine metabolism"], "types": ["T044"], "canonical_name": "indolalkylamine metabolic process", "definition": "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. [GOC:curators]"}
{"concept_id": "C1156929", "aliases": ["melatonin metabolism"], "types": ["T044"], "canonical_name": "melatonin metabolic process", "definition": "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine). [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1156930", "aliases": ["nicotianamine metabolism"], "types": ["T044"], "canonical_name": "nicotianamine metabolic process", "definition": "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. [GOC:mah, PMID:10069850]"}
{"concept_id": "C1156931", "aliases": ["polyamine metabolism"], "types": ["T044"], "canonical_name": "polyamine metabolic process", "definition": "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]"}
{"concept_id": "C1156932", "aliases": ["putrescine metabolism"], "types": ["T044"], "canonical_name": "putrescine metabolic process", "definition": "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine. [GOC:ai]"}
{"concept_id": "C1156933", "aliases": ["spermidine metabolism"], "types": ["T044"], "canonical_name": "spermidine metabolic process", "definition": "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]"}
{"concept_id": "C1156934", "aliases": ["nor-spermidine metabolism"], "types": ["T044"], "canonical_name": "nor-spermidine metabolic process", "definition": "The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]"}
{"concept_id": "C1156935", "aliases": ["trypanothione metabolism"], "types": ["T044"], "canonical_name": "trypanothione metabolic process", "definition": "The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress. [GOC:ai]"}
{"concept_id": "C1156936", "aliases": ["spermine metabolism"], "types": ["T044"], "canonical_name": "spermine metabolic process", "definition": "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. [GOC:curators]"}
{"concept_id": "C1156937", "aliases": ["thyroid hormone metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:jl, ISBN:0198506732]", "canonical_name": "thyroid hormone metabolism"}
{"concept_id": "C1156938", "aliases": [], "types": ["T044"], "canonical_name": "thyroid hormone generation", "definition": "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. [GOC:jl, ISBN:0716720094]"}
{"concept_id": "C1156939", "aliases": ["creatine metabolism"], "types": ["T044"], "canonical_name": "creatine metabolic process", "definition": "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1156940", "aliases": ["creatine biosynthesis", "creatine anabolism", "creatine formation", "creatine synthesis"], "types": ["T044"], "canonical_name": "creatine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle. [GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158]"}
{"concept_id": "C1156941", "aliases": ["creatinine metabolism"], "types": ["T044"], "canonical_name": "creatinine metabolic process", "definition": "The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. [ISBN:0198506732]"}
{"concept_id": "C1156942", "aliases": ["creatinine breakdown", "creatinine degradation", "creatinine catabolism"], "types": ["T044"], "canonical_name": "creatinine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. [ISBN:0198506732]"}
{"concept_id": "C1156943", "aliases": ["creatinine breakdown to formate", "creatinine degradation to formate"], "types": ["T044"], "canonical_name": "creatinine catabolic process to formate", "definition": "The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate. [GOC:go_curators]"}
{"concept_id": "C1156944", "aliases": ["cytokinin metabolism"], "types": ["T044"], "canonical_name": "cytokinin metabolic process", "definition": "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. [ISBN:0387969845]"}
{"concept_id": "C1156945", "aliases": ["cytokinin biosynthesis", "cytokinin synthesis", "cytokinin anabolism", "cytokinin formation"], "types": ["T044"], "canonical_name": "cytokinin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. [ISBN:0387969845]"}
{"concept_id": "C1156946", "aliases": ["cytokinin catabolism", "cytokinin degradation", "cytokinin breakdown"], "types": ["T044"], "canonical_name": "cytokinin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators. [GOC:lr]"}
{"concept_id": "C1156947", "aliases": ["desthiobiotin metabolic process", "desthiobiotin metabolism", "dethiobiotin metabolism"], "types": ["T044"], "canonical_name": "dethiobiotin metabolic process", "definition": "The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms. [ISBN:0198506732]"}
{"concept_id": "C1156948", "aliases": ["dethiobiotin formation", "desthiobiotin biosynthesis", "dethiobiotin biosynthesis", "dethiobiotin synthesis", "dethiobiotin anabolism", "desthiobiotin biosynthetic process"], "types": ["T044"], "canonical_name": "dethiobiotin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156949", "aliases": ["diaminopimelate metabolism"], "types": ["T044"], "canonical_name": "diaminopimelate metabolic process", "definition": "The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1156950", "aliases": ["methylammonium metabolism", "methylammonium metabolic process", "methylamine metabolism"], "types": ["T044"], "canonical_name": "methylamine metabolic process", "definition": "The chemical reactions and pathways involving methylamine (CH3NH2). [ISBN:0721662544]"}
{"concept_id": "C1156951", "aliases": ["p-aminobenzoic acid metabolism", "4-aminobenzoic acid metabolic process", "PABA metabolism", "vitamin Bx metabolism", "4-aminobenzoic acid metabolism", "PABA metabolic process", "p-aminobenzoic acid metabolic process", "para-aminobenzoic acid metabolism", "vitamin Bx metabolic process"], "types": ["T044"], "canonical_name": "para-aminobenzoic acid metabolic process", "definition": "The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins. [ISBN:0198506732, PMID:11377864, PMID:11960743]"}
{"concept_id": "C1156952", "aliases": ["p-aminobenzoic acid biosynthesis", "para-aminobenzoic acid biosynthesis", "para-aminobenzoic acid formation", "vitamin Bx biosynthesis", "para-aminobenzoic acid synthesis", "4-aminobenzoic acid biosynthetic process", "p-aminobenzoic acid biosynthetic process", "para-aminobenzoic acid anabolism", "4-aminobenzoic acid biosynthesis", "PABA biosynthetic process", "vitamin Bx biosynthetic process", "PABA biosynthesis"], "types": ["T044"], "canonical_name": "para-aminobenzoic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins. [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743]"}
{"concept_id": "C1156953", "aliases": ["phosphatidylethanolamine metabolism"], "types": ["T044"], "canonical_name": "phosphatidylethanolamine metabolic process", "definition": "The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. [GOC:curators, ISBN:0198506732]"}
{"concept_id": "C1156954", "aliases": ["phosphatidyl-N-monomethylethanolamine metabolism", "PMME metabolic process", "PMME metabolism"], "types": ["T044"], "canonical_name": "phosphatidyl-N-monomethylethanolamine metabolic process", "definition": "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria. [http://www.lipid.co.uk]"}
{"concept_id": "C1156955", "aliases": ["poly-N-acetyllactosamine metabolism"], "types": ["T044"], "canonical_name": "poly-N-acetyllactosamine metabolic process", "definition": "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. [GOC:mah, PMID:9405606]"}
{"concept_id": "C1156956", "aliases": ["poly-N-acetyllactosamine biosynthesis", "poly-N-acetyllactosamine anabolism", "poly-N-acetyllactosamine formation", "poly-N-acetyllactosamine synthesis"], "types": ["T044"], "canonical_name": "poly-N-acetyllactosamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. [GOC:mah, PMID:9405606]"}
{"concept_id": "C1156957", "aliases": ["poly-N-acetyllactosamine degradation", "poly-N-acetyllactosamine breakdown", "poly-N-acetyllactosamine catabolism"], "types": ["T044"], "canonical_name": "poly-N-acetyllactosamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. [GOC:mah, PMID:9405606]"}
{"concept_id": "C1156958", "aliases": ["S-adenosylmethioninamine metabolism"], "types": ["T044"], "canonical_name": "S-adenosylmethioninamine metabolic process", "definition": "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt. [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]"}
{"concept_id": "C1156961", "aliases": ["cellular modified amino acid metabolism", "cellular amino acid derivative metabolic process", "amino acid derivative metabolic process", "modified amino acid metabolism", "cellular amino acid derivative metabolism", "modified amino acid metabolic process"], "types": ["T044"], "canonical_name": "cellular modified amino acid metabolic process", "definition": "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. [GOC:ai]"}
{"concept_id": "C1156962", "aliases": ["aerobactin metabolism"], "types": ["T044"], "canonical_name": "aerobactin metabolic process", "definition": "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. [GOC:ai]"}
{"concept_id": "C1156963", "aliases": ["cellular amino acid derivative synthesis", "amino acid derivative biosynthetic process", "cellular amino acid derivative formation", "cellular modified amino acid anabolism", "cellular amino acid derivative biosynthetic process", "cellular modified amino acid formation", "cellular amino acid derivative biosynthesis", "cellular modified amino acid biosynthesis", "cellular modified amino acid synthesis", "cellular amino acid derivative anabolism"], "types": ["T044"], "canonical_name": "cellular modified amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. [GOC:ai]"}
{"concept_id": "C1156965", "aliases": ["hypusine anabolism", "hypusine formation from peptidyl-lysine", "hypusine formation", "hypusinylation", "hypusine synthesis from peptidyl-lysine", "hypusine biosynthesis", "hypusine biosynthetic process", "hypusine biosynthetic process from peptidyl-lysine", "protein hypusination", "hypusine synthesis", "hypusine anabolism from peptidyl-lysine"], "types": ["T044"], "canonical_name": "peptidyl-lysine modification to peptidyl-hypusine", "definition": "The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine. [GOC:ma, ISBN:0198547684, RESID:AA0116]"}
{"concept_id": "C1156966", "aliases": ["phenylpropanoid formation", "phenylpropanoid biosynthesis", "phenylpropanoid synthesis", "phenylpropanoid anabolism"], "types": ["T044"], "canonical_name": "phenylpropanoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid. [GOC:jl]"}
{"concept_id": "C1156967", "aliases": ["chalcone anabolism", "chalcone biosynthesis", "chalcone formation", "chalcone synthesis"], "types": ["T044"], "canonical_name": "chalcone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives. [GOC:go_curators]"}
{"concept_id": "C1156968", "aliases": ["cinnamic acid anabolism", "cinnamic acid formation", "phenylacrylic acid biosynthetic process", "cinnamylic acid biosynthesis", "phenylpropenoic acid biosynthesis", "cinnamylic acid biosynthetic process", "cinnamic acid synthesis", "phenylpropenoic acid biosynthetic process", "cinnamic acid biosynthesis", "phenylacrylic acid biosynthesis"], "types": ["T044"], "canonical_name": "cinnamic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid. [GOC:jl]"}
{"concept_id": "C1156969", "aliases": ["cinnamylic acid ester biosynthetic process", "cinnamylic acid ester biosynthesis", "cinnamic acid ester synthesis", "cinnamic acid ester anabolism", "phenylacrylic acid ester biosynthetic process", "cinnamic acid ester formation", "cinnamic acid ester biosynthesis", "phenylacrylic acid ester biosynthesis"], "types": ["T044"], "canonical_name": "cinnamic acid ester biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid. [GOC:jl]"}
{"concept_id": "C1156970", "aliases": ["flavonoid formation", "flavonoid synthesis", "flavonoid biosynthesis", "flavonoid anabolism"], "types": ["T044"], "canonical_name": "flavonoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. [GOC:tair_curators, ISBN:0198547684]"}
{"concept_id": "C1156971", "aliases": ["anthocyanin synthesis", "anthocyanin anabolism", "anthocyanin biosynthesis", "anthocyanin formation", "anthocyanin biosynthetic process"], "types": ["T044"], "canonical_name": "anthocyanin-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. [GOC:ai]"}
{"concept_id": "C1156972", "aliases": ["flavonoid phytoalexin biosynthesis", "flavonoid phytoalexin synthesis", "flavonoid phytoalexin anabolism", "flavonoid phytoalexin formation"], "types": ["T044"], "canonical_name": "flavonoid phytoalexin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. [ISBN:0198506732]"}
{"concept_id": "C1156973", "aliases": ["isoflavonoid biosynthesis", "isoflavonoid anabolism", "isoflavonoid synthesis", "isoflavonoid formation"], "types": ["T044"], "canonical_name": "isoflavonoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids. [GOC:ai]"}
{"concept_id": "C1156974", "aliases": ["lignan anabolism", "lignan formation", "lignan synthesis", "lignan biosynthesis"], "types": ["T044"], "canonical_name": "lignan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist. [GOC:jl, PMID:10074466]"}
{"concept_id": "C1156975", "aliases": ["lignin anabolism", "lignin synthesis", "lignin biosynthesis", "lignin formation"], "types": ["T044"], "canonical_name": "lignin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers. [GOC:tair_curators, ISBN:0198547684]"}
{"concept_id": "C1156976", "aliases": ["stilbene synthesis", "stilbene biosynthesis", "stilbene formation", "stilbene anabolism"], "types": ["T044"], "canonical_name": "stilbene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA. [GOC:tair_curators, ISBN:3110116251]"}
{"concept_id": "C1156977", "aliases": ["phosphagen formation", "phosphagen biosynthesis", "phosphagen synthesis", "phosphagen anabolism"], "types": ["T044"], "canonical_name": "phosphagen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156978", "aliases": ["phosphoarginine synthesis", "phosphoarginine biosynthesis", "phosphoarginine formation", "phosphoarginine anabolism"], "types": ["T044"], "canonical_name": "phosphoarginine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine. [GOC:ai]"}
{"concept_id": "C1156979", "aliases": ["phosphocreatine biosynthesis", "phosphocreatine anabolism", "phosphocreatine formation", "phosphocreatine synthesis"], "types": ["T044"], "canonical_name": "phosphocreatine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase. [GOC:ai]"}
{"concept_id": "C1156980", "aliases": ["prenylcysteine synthesis", "prenylcysteine formation", "prenylcysteine anabolism", "prenylcysteine biosynthesis"], "types": ["T044"], "canonical_name": "prenylcysteine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. [GOC:ai]"}
{"concept_id": "C1156981", "aliases": ["stachydrine anabolism", "stachydrine biosynthesis", "stachydrine formation", "stachydrine synthesis"], "types": ["T044"], "canonical_name": "stachydrine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline. [GOC:ai]"}
{"concept_id": "C1156982", "aliases": ["taurine formation", "taurine synthesis", "taurine anabolism", "taurine biosynthesis"], "types": ["T044"], "canonical_name": "taurine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. [GOC:jl, ISBN:0198600461]"}
{"concept_id": "C1156983", "aliases": ["Z-phenylacetaldoxime anabolism", "Z-phenylacetaldoxime formation", "Z-phenylacetaldoxime biosynthesis", "Z-phenylacetaldoxime synthesis"], "types": ["T044"], "canonical_name": "Z-phenylacetaldoxime biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds. [GOC:ai]"}
{"concept_id": "C1156984", "aliases": ["cellular modified amino acid catabolism", "modified amino acid catabolism", "cellular amino acid derivative breakdown", "modified amino acid catabolic process", "cellular modified amino acid degradation", "amino acid derivative catabolic process", "cellular amino acid derivative degradation", "cellular modified amino acid breakdown", "cellular amino acid derivative catabolism", "cellular amino acid derivative catabolic process"], "types": ["T044"], "canonical_name": "cellular modified amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. [GOC:ai]"}
{"concept_id": "C1156985", "aliases": ["ethylene catabolism", "ethene catabolism", "ethylene degradation", "ethylene breakdown", "ethene catabolic process"], "types": ["T044"], "canonical_name": "ethylene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. [GOC:jl, ISBN:0387969845]"}
{"concept_id": "C1156986", "aliases": ["nopaline catabolism", "nopaline degradation", "nopaline breakdown"], "types": ["T044"], "canonical_name": "nopaline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156987", "aliases": ["octopine breakdown", "octopine catabolism", "octopine degradation"], "types": ["T044"], "canonical_name": "octopine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1156988", "aliases": ["phenylpropanoid catabolism", "phenylpropanoid breakdown", "phenylpropanoid degradation"], "types": ["T044"], "canonical_name": "phenylpropanoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid. [GOC:ai]"}
{"concept_id": "C1156989", "aliases": ["chalcone degradation", "chalcone catabolism", "chalcone breakdown"], "types": ["T044"], "canonical_name": "chalcone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives. [GOC:ai]"}
{"concept_id": "C1156990", "aliases": ["phenylacrylic acid catabolism", "phenylacrylic acid catabolic process", "cinnamic acid catabolism", "cinnamic acid breakdown", "cinnamylic acid catabolism", "cinnamylic acid catabolic process", "cinnamic acid degradation"], "types": ["T044"], "canonical_name": "cinnamic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid. [GOC:ai]"}
{"concept_id": "C1156991", "aliases": ["cinnamic acid ester catabolism", "cinnamic acid ester degradation", "cinnamic acid ester breakdown"], "types": ["T044"], "canonical_name": "cinnamic acid ester catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid. [GOC:ai]"}
{"concept_id": "C1156992", "aliases": ["flavonoid catabolism", "flavonoid degradation", "flavonoid breakdown"], "types": ["T044"], "canonical_name": "flavonoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton. [GOC:ai]"}
{"concept_id": "C1156993", "aliases": ["anthocyanin catabolic process", "anthocyanin catabolism", "anthocyanin breakdown", "anthocyanin degradation"], "types": ["T044"], "canonical_name": "anthocyanin-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. [GOC:ai]"}
{"concept_id": "C1156994", "aliases": ["flavonoid phytoalexin catabolism", "flavonoid phytoalexin breakdown", "flavonoid phytoalexin degradation"], "types": ["T044"], "canonical_name": "flavonoid phytoalexin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. [GOC:ai]"}
{"concept_id": "C1156995", "aliases": ["isoflavonoid phytoalexin degradation", "isoflavonoid phytoalexin catabolism", "isoflavonoid phytoalexin breakdown"], "types": ["T044"], "canonical_name": "isoflavonoid phytoalexin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. [GOC:ai]"}
{"concept_id": "C1156996", "aliases": ["isoflavonoid catabolism", "isoflavonoid degradation", "isoflavonoid breakdown"], "types": ["T044"], "canonical_name": "isoflavonoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids. [GOC:ai]"}
{"concept_id": "C1156997", "aliases": ["lignan degradation", "lignan breakdown", "lignan catabolism"], "types": ["T044"], "canonical_name": "lignan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist. [GOC:jl, PMID:10074466]"}
{"concept_id": "C1156998", "aliases": ["lignin degradation", "lignin catabolism", "lignin breakdown"], "types": ["T044"], "canonical_name": "lignin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. [GOC:ai]"}
{"concept_id": "C1156999", "aliases": ["stilbene degradation", "stilbene breakdown", "stilbene catabolism"], "types": ["T044"], "canonical_name": "stilbene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA. [GOC:ai]"}
{"concept_id": "C1157000", "aliases": ["phosphagen degradation", "phosphagen breakdown", "phosphagen catabolism"], "types": ["T044"], "canonical_name": "phosphagen catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157001", "aliases": ["phosphoarginine catabolism", "phosphoarginine degradation", "phosphoarginine breakdown"], "types": ["T044"], "canonical_name": "phosphoarginine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine. [GOC:ai]"}
{"concept_id": "C1157002", "aliases": ["phosphocreatine degradation", "phosphocreatine breakdown", "phosphocreatine catabolism"], "types": ["T044"], "canonical_name": "phosphocreatine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase. [GOC:ai]"}
{"concept_id": "C1157003", "aliases": ["prenylcysteine degradation", "prenylcysteine catabolism", "prenylcysteine breakdown"], "types": ["T044"], "canonical_name": "prenylcysteine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. [GOC:ai]"}
{"concept_id": "C1157004", "aliases": ["stachydrine degradation", "stachydrine breakdown", "stachydrine catabolism"], "types": ["T044"], "canonical_name": "stachydrine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline. [GOC:ai]"}
{"concept_id": "C1157005", "aliases": ["taurine degradation", "taurine catabolism", "taurine breakdown"], "types": ["T044"], "canonical_name": "taurine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. [GOC:jl, ISBN:0198600461]"}
{"concept_id": "C1157006", "aliases": ["Z-phenylacetaldoxime degradation", "Z-phenylacetaldoxime breakdown", "Z-phenylacetaldoxime catabolism"], "types": ["T044"], "canonical_name": "Z-phenylacetaldoxime catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds. [GOC:ai]"}
{"concept_id": "C1157007", "aliases": ["ethylene metabolism", "ethene metabolism", "ethene metabolic process"], "types": ["T044"], "canonical_name": "ethylene metabolic process", "definition": "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. [ISBN:0387969845]"}
{"concept_id": "C1157008", "aliases": ["hypusine metabolism"], "types": ["T044"], "canonical_name": "hypusine metabolic process", "definition": "The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. [GOC:ai]"}
{"concept_id": "C1157009", "aliases": ["nopaline metabolism"], "types": ["T044"], "canonical_name": "nopaline metabolic process", "definition": "The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative. [GOC:ai]"}
{"concept_id": "C1157010", "aliases": ["octopine metabolism"], "types": ["T044"], "canonical_name": "octopine metabolic process", "definition": "The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine. [GOC:ai]"}
{"concept_id": "C1157011", "aliases": ["phenylpropanoid metabolism"], "types": ["T044"], "canonical_name": "phenylpropanoid metabolic process", "definition": "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. [GOC:jl]"}
{"concept_id": "C1157012", "aliases": ["chalcone metabolism"], "types": ["T044"], "canonical_name": "chalcone metabolic process", "definition": "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives. [ISBN:0198506732]"}
{"concept_id": "C1157013", "aliases": ["cinnamic acid ester metabolism"], "types": ["T044"], "canonical_name": "cinnamic acid ester metabolic process", "definition": "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid. [GOC:lr, GOC:yl]"}
{"concept_id": "C1157014", "aliases": ["phenylacrylic acid metabolism", "phenylpropenoic acid metabolic process", "cinnamylic acid metabolism", "cinnamylic acid metabolic process", "phenylacrylic acid metabolic process", "phenylpropenoic acid metabolism", "cinnamic acid metabolism"], "types": ["T044"], "canonical_name": "cinnamic acid metabolic process", "definition": "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid. [GOC:jl]"}
{"concept_id": "C1157015", "aliases": ["flavonoid metabolism"], "types": ["T044"], "canonical_name": "flavonoid metabolic process", "definition": "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. [GOC:tair_curators, ISBN:0198547684]"}
{"concept_id": "C1157016", "aliases": ["anthocyanin metabolism", "anthocyanin metabolic process"], "types": ["T044"], "canonical_name": "anthocyanin-containing compound metabolic process", "definition": "The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers. [ISBN:0198506732]"}
{"concept_id": "C1157017", "aliases": ["flavonoid phytoalexin metabolism"], "types": ["T044"], "canonical_name": "flavonoid phytoalexin metabolic process", "definition": "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. [ISBN:0198506732]"}
{"concept_id": "C1157018", "aliases": ["isoflavonoid phytoalexin metabolism"], "types": ["T044"], "canonical_name": "isoflavonoid phytoalexin metabolic process", "definition": "The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. [GOC:ai]"}
{"concept_id": "C1157019", "aliases": ["isoflavonoid metabolism"], "types": ["T044"], "canonical_name": "isoflavonoid metabolic process", "definition": "The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring group. [GOC:ai, PMID:15734910]"}
{"concept_id": "C1157020", "aliases": ["lignan metabolism"], "types": ["T044"], "canonical_name": "lignan metabolic process", "definition": "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist. [GOC:jl, PMID:10074466]"}
{"concept_id": "C1157021", "aliases": ["lignin metabolism"], "types": ["T044"], "canonical_name": "lignin metabolic process", "definition": "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units. [GOC:lr, GOC:yl]"}
{"concept_id": "C1157022", "aliases": ["stilbene metabolism"], "types": ["T044"], "canonical_name": "stilbene metabolic process", "definition": "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA. [ISBN:3110116251]"}
{"concept_id": "C1157023", "aliases": ["phosphagen metabolism"], "types": ["T044"], "canonical_name": "phosphagen metabolic process", "definition": "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157024", "aliases": ["phosphoarginine metabolism"], "types": ["T044"], "canonical_name": "phosphoarginine metabolic process", "definition": "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates. [GOC:curators, PMID:16371597]"}
{"concept_id": "C1157025", "aliases": ["phosphocreatine metabolism"], "types": ["T044"], "canonical_name": "phosphocreatine metabolic process", "definition": "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle. [PMID:16371597]"}
{"concept_id": "C1157026", "aliases": ["prenylcysteine metabolism"], "types": ["T044"], "canonical_name": "prenylcysteine metabolic process", "definition": "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. [GOC:ai, PMID:16627894]"}
{"concept_id": "C1157027", "aliases": ["S-adenosylhomocysteine metabolism"], "types": ["T044"], "canonical_name": "S-adenosylhomocysteine metabolic process", "definition": "The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. [ISBN:0198506732]"}
{"concept_id": "C1157028", "aliases": ["SAM metabolic process", "S-adenosyl methionine metabolism", "S-adenosylmethionine metabolism", "S-adenosyl methionine metabolic process"], "types": ["T044"], "canonical_name": "S-adenosylmethionine metabolic process", "definition": "The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157029", "aliases": ["stachydrine metabolism"], "types": ["T044"], "canonical_name": "stachydrine metabolic process", "definition": "The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants. [GOC:curators, MetaCyc:CPD-821]"}
{"concept_id": "C1157030", "aliases": ["taurine metabolism"], "types": ["T044"], "canonical_name": "taurine metabolic process", "definition": "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. [GOC:jl, ISBN:0198600461]"}
{"concept_id": "C1157031", "aliases": ["Z-phenylacetaldoxime metabolism"], "types": ["T044"], "canonical_name": "Z-phenylacetaldoxime metabolic process", "definition": "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants. [UM-BBD_pathwayID:car]"}
{"concept_id": "C1157032", "aliases": ["aromatic compound metabolism"], "types": ["T044"], "canonical_name": "cellular aromatic compound metabolic process", "definition": "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1157033", "aliases": ["aromatic compound synthesis", "aromatic compound biosynthesis", "aromatic compound anabolism", "aromatic compound formation"], "types": ["T044"], "canonical_name": "aromatic compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. [GOC:ai]"}
{"concept_id": "C1157034", "aliases": ["coumarin formation", "coumarin anabolism", "coumarin biosynthesis", "coumarin synthesis"], "types": ["T044"], "canonical_name": "coumarin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids. [GOC:lr, GOC:yl]"}
{"concept_id": "C1157035", "aliases": ["ectoine anabolism", "ectoine biosynthesis", "ectoine formation", "ectoine synthesis"], "types": ["T044"], "canonical_name": "ectoine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria. [GOC:jl, PMID:11823218]"}
{"concept_id": "C1157036", "aliases": ["mandelate biosynthesis", "mandelate anabolism", "mandelate formation", "mandelate synthesis"], "types": ["T044"], "canonical_name": "mandelate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. [GOC:ai]"}
{"concept_id": "C1157037", "aliases": ["pteridine-containing compound biosynthetic process", "pterin biosynthesis", "pterin biosynthetic process", "pteridine and derivative biosynthesis", "pteridine-containing compound formation", "pteridine-containing compound synthesis", "pteridine and derivative biosynthetic process", "pteridine-containing compound anabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. [GOC:jl, ISBN:0198506732]", "canonical_name": "pteridine-containing compound biosynthesis"}
{"concept_id": "C1157038", "aliases": ["folate biosynthetic process", "folic acid formation", "folic acid biosynthetic process", "vitamin M biosynthesis", "folic acid synthesis", "folate biosynthesis", "vitamin B9 biosynthesis", "folic acid anabolism", "folic acid biosynthesis", "vitamin B9 biosynthetic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. [GOC:ai]", "canonical_name": "vitamin M biosynthetic process"}
{"concept_id": "C1157039", "aliases": ["Moco biosynthesis", "Moco biosynthetic process", "Mo-molybdopterin cofactor formation", "Mo-molybdopterin cofactor synthesis", "Mo-molybdopterin cofactor biosynthesis", "Mo-molybdopterin cofactor anabolism"], "types": ["T044"], "canonical_name": "Mo-molybdopterin cofactor biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]"}
{"concept_id": "C1157040", "aliases": ["pterin biosynthesis", "pteridine synthesis", "pteridine biosynthetic process", "pterin biosynthetic process", "pteridine formation", "pteridine biosynthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. [ISBN:0198506732]", "canonical_name": "pteridine anabolism"}
{"concept_id": "C1157041", "aliases": ["tetrahydrobiopterin formation", "tetrahydrobiopterin anabolism", "tetrahydrobiopterin biosynthesis", "5,6,7,8-tetrahydrobiopterin biosynthetic process", "tetrahydrobiopterin synthesis"], "types": ["T044"], "canonical_name": "tetrahydrobiopterin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. [ISBN:0198506732]"}
{"concept_id": "C1157042", "aliases": ["W-molybdopterin cofactor formation", "W-molybdopterin cofactor biosynthesis", "W-molybdopterin cofactor anabolism", "W-molybdopterin cofactor synthesis"], "types": ["T044"], "canonical_name": "W-molybdopterin cofactor biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. [ISSN:09498257]"}
{"concept_id": "C1157043", "aliases": ["pyridine biosynthesis", "pyridine anabolism", "pyridine synthesis", "pyridine formation"], "types": ["T044"], "canonical_name": "pyridine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor. [GOC:ai]"}
{"concept_id": "C1157044", "aliases": ["quinate anabolism", "quinic acid biosynthetic process", "quinate formation", "quinate synthesis", "quinate biosynthesis", "quinic acid biosynthesis"], "types": ["T044"], "canonical_name": "quinate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid. [GOC:go_curators]"}
{"concept_id": "C1157045", "aliases": ["salicylate biosynthetic process", "salicylic acid biosynthesis", "salicylic acid anabolism", "salicylic acid synthesis", "salicylic acid formation"], "types": ["T044"], "canonical_name": "salicylic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid. [ISBN:0943088399]"}
{"concept_id": "C1157046", "aliases": ["sophorosyloxydocosanoate anabolism", "sophorosyloxydocosanoate biosynthesis", "sophorosyloxydocosanoate synthesis", "sophorosyloxydocosanoate formation"], "types": ["T044"], "canonical_name": "sophorosyloxydocosanoate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate. [GOC:ai]"}
{"concept_id": "C1157047", "aliases": ["aromatic compound breakdown", "aromatic compound catabolism", "aromatic compound degradation"], "types": ["T044"], "canonical_name": "aromatic compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. [GOC:ai]"}
{"concept_id": "C1157048", "aliases": ["coumarin degradation", "coumarin breakdown", "coumarin catabolism"], "types": ["T044"], "canonical_name": "coumarin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. [GOC:ai]"}
{"concept_id": "C1157049", "aliases": ["ectoine catabolism", "ectoine degradation", "ectoine breakdown"], "types": ["T044"], "canonical_name": "ectoine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria. [GOC:jl, PMID:11823218]"}
{"concept_id": "C1157050", "aliases": ["indole-containing compound degradation", "indole-containing compound catabolism", "indole-containing compound breakdown", "indole derivative catabolism", "indole derivative catabolic process"], "types": ["T044"], "canonical_name": "indole-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. [GOC:jl]"}
{"concept_id": "C1157051", "aliases": ["indole glucosinolate degradation", "indole glucosinolate catabolism", "indole glucosinolate breakdown"], "types": ["T044"], "canonical_name": "indole glucosinolate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan. [PMID:29122987]"}
{"concept_id": "C1157052", "aliases": ["indole phytoalexin catabolism", "indole phytoalexin degradation", "indole phytoalexin breakdown"], "types": ["T044"], "canonical_name": "indole phytoalexin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response. [GOC:ai]"}
{"concept_id": "C1157053", "aliases": ["indole acetic acid catabolism", "indoleacetic acid degradation", "indole acetic acid catabolic process", "indoleacetic acid catabolism", "indoleacetic acid breakdown", "IAA catabolic process"], "types": ["T044"], "canonical_name": "indoleacetic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants. [GOC:jl]"}
{"concept_id": "C1157054", "aliases": ["mandelate breakdown", "mandelate degradation", "mandelate catabolism"], "types": ["T044"], "canonical_name": "mandelate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. [GOC:go_curators]"}
{"concept_id": "C1157055", "aliases": ["pteridine-containing compound degradation", "pteridine-containing compound breakdown", "pteridine and derivative catabolic process", "pteridine-containing compound catabolism", "pteridine and derivative catabolism"], "types": ["T044"], "canonical_name": "pteridine-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157056", "aliases": ["folate catabolism", "folic acid breakdown", "folate catabolic process", "folic acid catabolic process", "folic acid degradation", "folic acid catabolism", "vitamin B9 catabolic process", "vitamin B9 catabolism", "vitamin M catabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid. [GOC:ai]", "canonical_name": "vitamin M catabolic process"}
{"concept_id": "C1157057", "aliases": ["pteridine breakdown", "pteridine catabolism", "pteridine degradation"], "types": ["T044"], "canonical_name": "pteridine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. [ISBN:0198506732]"}
{"concept_id": "C1157058", "aliases": ["tetrahydrobiopterin breakdown", "5,6,7,8-tetrahydrobiopterin catabolic process", "tetrahydrobiopterin degradation", "tetrahydrobiopterin catabolism"], "types": ["T044"], "canonical_name": "tetrahydrobiopterin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. [ISBN:0198506732]"}
{"concept_id": "C1157059", "aliases": ["pyridine breakdown", "pyridine degradation", "pyridine catabolism"], "types": ["T044"], "canonical_name": "pyridine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor. [GOC:ai]"}
{"concept_id": "C1157060", "aliases": ["quinic acid catabolic process", "quinate catabolism", "quinate breakdown", "quinate degradation", "quinic acid catabolism"], "types": ["T044"], "canonical_name": "quinate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid. [GOC:jl]"}
{"concept_id": "C1157061", "aliases": ["salicylic acid catabolism", "salicylic acid breakdown", "salicylic acid degradation"], "types": ["T044"], "canonical_name": "salicylic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid. [GOC:ai]"}
{"concept_id": "C1157062", "aliases": ["sophorosyloxydocosanoate degradation", "sophorosyloxydocosanoate catabolism", "sophorosyloxydocosanoate breakdown"], "types": ["T044"], "canonical_name": "sophorosyloxydocosanoate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate. [GOC:ai]"}
{"concept_id": "C1157063", "aliases": ["benzyl isoquinoline alkaloid metabolism"], "types": ["T044"], "canonical_name": "benzyl isoquinoline alkaloid metabolic process", "definition": "The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1157064", "aliases": ["benzyl isoquinoline alkaloid biosynthesis", "benzyl isoquinoline alkaloid synthesis", "benzyl isoquinoline alkaloid formation", "benzyl isoquinoline alkaloid anabolism"], "types": ["T044"], "canonical_name": "benzyl isoquinoline alkaloid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1157065", "aliases": ["coumarin metabolism"], "types": ["T044"], "canonical_name": "coumarin metabolic process", "definition": "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. [GOC:lr, GOC:yl]"}
{"concept_id": "C1157066", "aliases": ["ectoine metabolism"], "types": ["T044"], "canonical_name": "ectoine metabolic process", "definition": "The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria. [GOC:jl, PMID:11823218]"}
{"concept_id": "C1157067", "aliases": ["enterochelin metabolic process", "enterochelin metabolism", "enterobactin metabolism"], "types": ["T044"], "canonical_name": "enterobactin metabolic process", "definition": "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. [ISBN:0198547684]"}
{"concept_id": "C1157068", "aliases": ["enterobactin breakdown", "enterobactin degradation", "enterobactin catabolism"], "types": ["T044"], "canonical_name": "enterobactin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. [GOC:ai]"}
{"concept_id": "C1157069", "aliases": ["folic acid and derivative metabolic process", "folate-containing compound metabolism", "folic acid-containing compound metabolism", "vitamin M and derivative metabolic process", "vitamin M and derivative metabolism", "folate and derivative metabolism", "vitamin B9 and derivative metabolic process", "vitamin B9 and derivative metabolism", "folate and derivative metabolic process", "folic acid and derivative metabolism", "folate-containing compound metabolic process"], "types": ["T044"], "canonical_name": "folic acid-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. [GOC:ai, GOC:mah]"}
{"concept_id": "C1157070", "aliases": ["10-formyl-THF metabolism", "10-formyl-THF metabolic process", "10-formyltetrahydrofolate metabolism"], "types": ["T044"], "canonical_name": "10-formyltetrahydrofolate metabolic process", "definition": "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. [GOC:ai]"}
{"concept_id": "C1157071", "aliases": ["10-formyltetrahydrofolate biosynthesis", "10-formyltetrahydrofolate anabolism", "10-formyltetrahydrofolate synthesis", "10-formyltetrahydrofolate formation", "10-formyl-THF biosynthetic process", "10-formyl-THF biosynthesis"], "types": ["T044"], "canonical_name": "10-formyltetrahydrofolate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. [GOC:ai]"}
{"concept_id": "C1157072", "aliases": ["10-formyl-THF catabolism", "10-formyltetrahydrofolate catabolism", "10-formyltetrahydrofolate degradation", "10-formyltetrahydrofolate breakdown", "10-formyl-THF catabolic process"], "types": ["T044"], "canonical_name": "10-formyltetrahydrofolate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. [GOC:ai]"}
{"concept_id": "C1157073", "aliases": ["dihydrofolate metabolism"], "types": ["T044"], "canonical_name": "dihydrofolate metabolic process", "definition": "The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate. [ISBN:0198506732]"}
{"concept_id": "C1157074", "aliases": ["7,8-dihydrofolate biosynthetic process", "7,8-dihydrofolate biosynthesis", "dihydrofolate synthesis", "dihydrofolate formation", "dihydrofolate anabolism", "dihydrofolate biosynthesis"], "types": ["T044"], "canonical_name": "dihydrofolate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate. [GOC:ai]"}
{"concept_id": "C1157076", "aliases": ["folate-containing compound biosynthetic process", "vitamin M and derivative biosynthesis", "folic acid-containing compound formation", "vitamin B9 and derivative biosynthetic process", "folate-containing compound biosynthesis", "folate and derivative biosynthesis", "folic acid and derivative biosynthetic process", "vitamin M and derivative biosynthetic process", "vitamin B9 and derivative biosynthesis", "folic acid-containing compound anabolism", "folic acid-containing compound synthesis", "folate and derivative biosynthetic process", "folic acid-containing compound biosynthesis", "folic acid and derivative biosynthesis"], "types": ["T044"], "canonical_name": "folic acid-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. [GOC:ai]"}
{"concept_id": "C1157077", "aliases": ["tetrahydrofolate formation", "tetrahydrofolate anabolism", "tetrahydrofolate biosynthesis", "tetrahydrofolate synthesis"], "types": ["T044"], "canonical_name": "tetrahydrofolate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. [ISBN:0198506732]"}
{"concept_id": "C1157078", "aliases": ["vitamin M and derivative catabolic process", "folate and derivative catabolism", "folic acid and derivative catabolism", "folate and derivative catabolic process", "folic acid-containing compound breakdown", "folate-containing compound catabolism", "vitamin M and derivative catabolism", "folic acid and derivative catabolic process", "folic acid-containing compound degradation", "vitamin B9 and derivative catabolic process", "vitamin B9 and derivative catabolism", "folate-containing compound catabolic process", "folic acid-containing compound catabolism"], "types": ["T044"], "canonical_name": "folic acid-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives. [GOC:ai]"}
{"concept_id": "C1157079", "aliases": ["vitamin B9 metabolism", "folate metabolic process", "vitamin M metabolism", "vitamin B9 metabolic process", "vitamin M metabolic process", "folic acid metabolic process", "folic acid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [ISBN:0198506732]", "canonical_name": "folate metabolism"}
{"concept_id": "C1157080", "aliases": ["tetrahydrofolate metabolism"], "types": ["T044"], "canonical_name": "tetrahydrofolate metabolic process", "definition": "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. [ISBN:0198506732]"}
{"concept_id": "C1157081", "aliases": ["indole-containing compound metabolism", "ketole metabolic process", "indole derivative metabolic process", "indole and derivative metabolic process", "indole and derivative metabolism", "ketole metabolism", "indole derivative metabolism"], "types": ["T044"], "canonical_name": "indole-containing compound metabolic process", "definition": "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. [GOC:jl, GOC:mah]"}
{"concept_id": "C1157083", "aliases": ["indole derivative biosynthetic process", "indole-containing compound synthesis", "indole-containing compound biosynthesis", "indole-containing compound formation", "indole derivative biosynthesis", "indole-containing compound anabolism"], "types": ["T044"], "canonical_name": "indole-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. [GOC:jl]"}
{"concept_id": "C1157084", "aliases": ["indole glucosinolate biosynthesis", "indole glucosinolate synthesis", "indole glucosinolate anabolism", "indole glucosinolate formation"], "types": ["T044"], "canonical_name": "indole glucosinolate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan. [GOC:ai]"}
{"concept_id": "C1157085", "aliases": ["indole-3-acetate biosynthesis", "indole acetic acid biosynthesis", "indole-acetic acid biosynthetic process", "indole-3-acetate biosynthetic process", "indole-acetic acid biosynthesis", "IAA biosynthetic process", "indoleacetic acid synthesis", "indoleacetic acid anabolism", "indoleacetic acid biosynthesis", "indoleacetic acid formation", "indole acetic acid biosynthetic process"], "types": ["T044"], "canonical_name": "indoleacetic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants. [ISBN:0387969845]"}
{"concept_id": "C1157086", "aliases": ["indoleacetic acid biosynthesis, tryptophan-independent", "tryptophan-independent indoleacetic acid formation", "tryptophan-independent indoleacetic acid biosynthesis", "tryptophan-independent indoleacetic acid synthesis", "indoleacetic acid biosynthetic process, tryptophan-independent", "tryptophan-independent indoleacetic acid anabolism", "tryptophan-independent IAA biosynthetic process"], "types": ["T044"], "canonical_name": "tryptophan-independent indoleacetic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan. [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566]"}
{"concept_id": "C1157087", "aliases": ["indole glucosinolate metabolism"], "types": ["T044"], "canonical_name": "indole glucosinolate metabolic process", "definition": "The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan. [GOC:curators]"}
{"concept_id": "C1157088", "aliases": ["indole phytoalexin metabolism"], "types": ["T044"], "canonical_name": "indole phytoalexin metabolic process", "definition": "The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response. [GOC:ai]"}
{"concept_id": "C1157089", "aliases": ["IAA metabolic process", "indoleacetic acid metabolism", "indole acetic acid metabolism", "indole acetic acid metabolic process"], "types": ["T044"], "canonical_name": "indoleacetic acid metabolic process", "definition": "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants. [GOC:mah]"}
{"concept_id": "C1157090", "aliases": ["terpenoid indole alkaloid biosynthesis", "terpenoid indole alkaloid formation", "terpenoid indole alkaloid anabolism", "terpenoid indole alkaloid synthesis"], "types": ["T044"], "canonical_name": "terpenoid indole alkaloid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate). [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html]"}
{"concept_id": "C1157091", "aliases": ["indole metabolism"], "types": ["T044"], "canonical_name": "indole metabolic process", "definition": "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). [GOC:jl]"}
{"concept_id": "C1157092", "aliases": ["indole formation", "indole biosynthesis", "indole synthesis", "indole anabolism"], "types": ["T044"], "canonical_name": "indole biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). [GOC:jl]"}
{"concept_id": "C1157093", "aliases": ["indole breakdown", "indole degradation", "indole catabolism"], "types": ["T044"], "canonical_name": "indole catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). [GOC:jl]"}
{"concept_id": "C1157094", "aliases": ["mandelic acid metabolic process", "mandelic acid metabolism", "mandelate metabolism"], "types": ["T044"], "canonical_name": "mandelate metabolic process", "definition": "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. [GOC:jl]"}
{"concept_id": "C1157095", "aliases": ["nucleobase metabolism"], "types": ["T044"], "canonical_name": "nucleobase metabolic process", "definition": "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. [GOC:ma]"}
{"concept_id": "C1157096", "aliases": ["nucleobase biosynthesis", "nucleobase synthesis", "nucleobase anabolism", "nucleobase formation"], "types": ["T044"], "canonical_name": "nucleobase biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. [GOC:ai]"}
{"concept_id": "C1157097", "aliases": ["purine base formation", "purine base biosynthesis", "purine base biosynthetic process", "purine base synthesis", "purine base anabolism"], "types": ["T044"], "canonical_name": "purine nucleobase biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. [ISBN:0198506732]"}
{"concept_id": "C1157098", "aliases": ["adenine formation", "adenine anabolism", "adenine synthesis", "adenine biosynthesis"], "types": ["T044"], "canonical_name": "adenine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. [GOC:go_curators]"}
{"concept_id": "C1157099", "aliases": ["guanine biosynthesis", "guanine anabolism", "guanine synthesis", "guanine formation"], "types": ["T044"], "canonical_name": "guanine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. [GOC:go_curators]"}
{"concept_id": "C1157100", "aliases": ["hypoxanthine synthesis", "hypoxanthine anabolism", "hypoxanthine formation", "hypoxanthine biosynthesis"], "types": ["T044"], "canonical_name": "hypoxanthine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. [GOC:go_curators]"}
{"concept_id": "C1157101", "aliases": ["xanthine synthesis", "xanthine formation", "xanthine anabolism", "xanthine biosynthesis"], "types": ["T044"], "canonical_name": "xanthine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. [GOC:go_curators]"}
{"concept_id": "C1157102", "aliases": ["pyrimidine base synthesis", "pyrimidine base biosynthetic process", "pyrimidine base formation", "pyrimidine base biosynthesis", "pyrimidine base anabolism"], "types": ["T044"], "canonical_name": "pyrimidine nucleobase biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. [GOC:go_curators]"}
{"concept_id": "C1157103", "aliases": ["'de novo' pyrimidine base biosynthesis", "'de novo' pyrimidine base anabolism", "'de novo' pyrimidine base biosynthetic process", "'de novo' pyrimidine base formation", "'de novo' pyrimidine base synthesis"], "types": ["T044"], "canonical_name": "'de novo' pyrimidine nucleobase biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. [GOC:mah, ISBN:0716720094]"}
{"concept_id": "C1157104", "aliases": ["5-methylcytosine formation", "5-methylcytosine biosynthesis", "5-methylcytosine anabolism", "5-methylcytosine synthesis"], "types": ["T044"], "canonical_name": "5-methylcytosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA. [GOC:go_curators]"}
{"concept_id": "C1157105", "aliases": ["cytosine anabolism", "cytosine formation", "cytosine biosynthesis", "cytosine synthesis"], "types": ["T044"], "canonical_name": "cytosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. [GOC:go_curators]"}
{"concept_id": "C1157106", "aliases": ["thymine biosynthesis", "thymine synthesis", "thymine formation", "thymine anabolism"], "types": ["T044"], "canonical_name": "thymine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. [GOC:go_curators]"}
{"concept_id": "C1157107", "aliases": ["uracil biosynthesis", "uracil formation", "uracil anabolism", "uracil synthesis"], "types": ["T044"], "canonical_name": "uracil biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. [GOC:go_curators]"}
{"concept_id": "C1157108", "aliases": ["nucleobase catabolism", "nucleobase breakdown", "nucleobase degradation"], "types": ["T044"], "canonical_name": "nucleobase catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. [GOC:ai]"}
{"concept_id": "C1157109", "aliases": ["purine base catabolism", "purine base degradation", "purine base catabolic process", "purine base breakdown"], "types": ["T044"], "canonical_name": "purine nucleobase catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. [GOC:go_curators]"}
{"concept_id": "C1157110", "aliases": ["adenine degradation", "adenine catabolism", "adenine breakdown"], "types": ["T044"], "canonical_name": "adenine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. [ISBN:0198506732]"}
{"concept_id": "C1157111", "aliases": ["guanine catabolism", "guanine degradation", "guanine breakdown"], "types": ["T044"], "canonical_name": "guanine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. [GOC:go_curators]"}
{"concept_id": "C1157112", "aliases": ["hypoxanthine breakdown", "hypoxanthine catabolism", "hypoxanthine degradation"], "types": ["T044"], "canonical_name": "hypoxanthine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. [PMID:3196295]"}
{"concept_id": "C1157114", "aliases": ["xanthine catabolism", "xanthine breakdown", "xanthine degradation"], "types": ["T044"], "canonical_name": "xanthine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. [GOC:go_curators]"}
{"concept_id": "C1157116", "aliases": ["pyrimidine base catabolism", "pyrimidine base catabolic process", "pyrimidine base degradation", "pyrimidine base breakdown"], "types": ["T044"], "canonical_name": "pyrimidine nucleobase catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. [GOC:go_curators]"}
{"concept_id": "C1157117", "aliases": ["5-methylcytosine breakdown", "5-methylcytosine catabolism", "5-methylcytosine degradation"], "types": ["T044"], "canonical_name": "5-methylcytosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA. [GOC:go_curators]"}
{"concept_id": "C1157118", "aliases": ["cytosine catabolism", "cytosine degradation", "cytosine breakdown"], "types": ["T044"], "canonical_name": "cytosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. [GOC:go_curators]"}
{"concept_id": "C1157119", "aliases": ["thymine catabolism", "thymine breakdown", "thymine degradation"], "types": ["T044"], "canonical_name": "thymine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. [GOC:go_curators]"}
{"concept_id": "C1157120", "aliases": ["uracil catabolism", "uracil degradation", "uracil breakdown"], "types": ["T044"], "canonical_name": "uracil catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. [GOC:go_curators]"}
{"concept_id": "C1157121", "aliases": ["purine base metabolic process", "purine base metabolism"], "types": ["T044"], "canonical_name": "purine nucleobase metabolic process", "definition": "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. [GOC:go_curators]"}
{"concept_id": "C1157122", "aliases": ["adenine metabolism"], "types": ["T044"], "canonical_name": "adenine metabolic process", "definition": "The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. [GOC:go_curators]"}
{"concept_id": "C1157123", "aliases": ["guanine metabolism"], "types": ["T044"], "canonical_name": "guanine metabolic process", "definition": "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. [GOC:go_curators]"}
{"concept_id": "C1157124", "aliases": ["GMP breakdown to guanine", "GMP degradation to guanine"], "types": ["T044"], "canonical_name": "GMP catabolic process to guanine", "definition": "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine. [ISBN:0198506732]"}
{"concept_id": "C1157125", "aliases": ["hypoxanthine metabolism"], "types": ["T044"], "canonical_name": "hypoxanthine metabolic process", "definition": "The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. [GOC:go_curators]"}
{"concept_id": "C1157126", "aliases": ["anaerobic purine catabolic process", "anaerobic purine base catabolic process", "purine base fermentation", "anaerobic purine base catabolism", "purine fermentation"], "types": ["T044"], "canonical_name": "anaerobic purine nucleobase catabolic process", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of purine nucleobases, yielding energy in the form of ATP. [GOC:mah]"}
{"concept_id": "C1157127", "aliases": ["regulation of purine base metabolic process", "regulation of purine base metabolism"], "types": ["T043"], "canonical_name": "regulation of purine nucleobase metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines. [GOC:go_curators]"}
{"concept_id": "C1157128", "aliases": ["negative regulation of purine base metabolic process", "downregulation of purine base metabolic process", "down regulation of purine base metabolic process", "down-regulation of purine base metabolic process", "negative regulation of purine base metabolism"], "types": ["T043"], "canonical_name": "negative regulation of purine nucleobase metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases. [GOC:go_curators]"}
{"concept_id": "C1157129", "aliases": ["positive regulation of purine base metabolic process", "upregulation of purine base metabolic process", "up regulation of purine base metabolic process", "positive regulation of purine base metabolism", "up-regulation of purine base metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of purine nucleobase metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases. [GOC:go_curators]"}
{"concept_id": "C1157130", "aliases": ["xanthine metabolism"], "types": ["T044"], "canonical_name": "xanthine metabolic process", "definition": "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. [GOC:go_curators]"}
{"concept_id": "C1157131", "aliases": ["pyrimidine base metabolism", "pyrimidine base metabolic process"], "types": ["T044"], "canonical_name": "pyrimidine nucleobase metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. [GOC:go_curators]"}
{"concept_id": "C1157132", "aliases": ["5-methylcytosine metabolism"], "types": ["T044"], "canonical_name": "5-methylcytosine metabolic process", "definition": "The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA. [GOC:ai]"}
{"concept_id": "C1157133", "aliases": ["cytosine metabolism"], "types": ["T044"], "canonical_name": "cytosine metabolic process", "definition": "The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. [GOC:ai]"}
{"concept_id": "C1157134", "aliases": ["regulation of pyrimidine base metabolic process", "regulation of pyrimidine base metabolism"], "types": ["T043"], "canonical_name": "regulation of pyrimidine nucleobase metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases. [GOC:go_curators]"}
{"concept_id": "C1157135", "aliases": ["downregulation of pyrimidine base metabolic process", "negative regulation of pyrimidine base metabolic process", "down regulation of pyrimidine base metabolic process", "negative regulation of pyrimidine base metabolism", "down-regulation of pyrimidine base metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of pyrimidine nucleobase metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases. [GOC:go_curators]"}
{"concept_id": "C1157136", "aliases": ["positive regulation of pyrimidine base metabolism", "positive regulation of pyrimidine base metabolic process", "up regulation of pyrimidine base metabolic process", "up-regulation of pyrimidine base metabolic process", "upregulation of pyrimidine base metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of pyrimidine nucleobase metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases. [GOC:go_curators]"}
{"concept_id": "C1157137", "aliases": ["thymine metabolism"], "types": ["T044"], "canonical_name": "thymine metabolic process", "definition": "The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. [GOC:go_curators]"}
{"concept_id": "C1157138", "aliases": ["uracil metabolism"], "types": ["T044"], "canonical_name": "uracil metabolic process", "definition": "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. [GOC:go_curators]"}
{"concept_id": "C1157139", "aliases": ["ommochrome metabolism"], "types": ["T044"], "canonical_name": "ommochrome metabolic process", "definition": "The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. [ISBN:0198506732]"}
{"concept_id": "C1157140", "aliases": ["ommochrome biosynthesis", "ommochrome formation", "ommochrome synthesis", "ommochrome anabolism"], "types": ["T044"], "canonical_name": "ommochrome biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. [ISBN:0198506732]"}
{"concept_id": "C1157141", "aliases": ["ommochrome catabolism", "ommochrome degradation", "ommochrome breakdown"], "types": ["T044"], "canonical_name": "ommochrome catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. [ISBN:0198506732]"}
{"concept_id": "C1157142", "aliases": ["pteridine and derivative metabolism", "pteridine-containing compound metabolism", "pteridine and derivative metabolic process"], "types": ["T044"], "canonical_name": "pteridine-containing compound metabolic process", "definition": "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157143", "aliases": ["dihydrobiopterin reduction"], "types": ["T044"], "canonical_name": "dihydrobiopterin reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1157144", "aliases": ["dihydropteridine reduction"], "types": ["T044"], "canonical_name": "dihydropteridine reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1157145", "aliases": ["Mo-molybdopterin cofactor metabolism"], "types": ["T044"], "canonical_name": "Mo-molybdopterin cofactor metabolic process", "definition": "The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]"}
{"concept_id": "C1157146", "aliases": ["pteridine metabolism"], "types": ["T044"], "canonical_name": "pteridine metabolic process", "definition": "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157147", "aliases": ["regulation of pteridine metabolism"], "types": ["T043"], "canonical_name": "regulation of pteridine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine. [GOC:go_curators]"}
{"concept_id": "C1157148", "aliases": ["negative regulation of pteridine metabolism", "down-regulation of pteridine metabolic process", "down regulation of pteridine metabolic process", "downregulation of pteridine metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of pteridine metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine. [GOC:go_curators]"}
{"concept_id": "C1157149", "aliases": ["up regulation of pteridine metabolic process", "positive regulation of pteridine metabolism", "up-regulation of pteridine metabolic process", "upregulation of pteridine metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of pteridine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine. [GOC:go_curators]"}
{"concept_id": "C1157150", "aliases": ["tetrahydrobiopterin metabolism", "5,6,7,8-tetrahydrobiopterin metabolic process"], "types": ["T044"], "canonical_name": "tetrahydrobiopterin metabolic process", "definition": "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. [PMID:21871890]"}
{"concept_id": "C1157151", "aliases": ["W-molybdopterin cofactor metabolism"], "types": ["T044"], "canonical_name": "W-molybdopterin cofactor metabolic process", "definition": "The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. [ISSN:09498257]"}
{"concept_id": "C1157152", "aliases": ["pyridine metabolism"], "types": ["T044"], "canonical_name": "pyridine metabolic process", "definition": "The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor. [GOC:curators]"}
{"concept_id": "C1157153", "aliases": ["2,5-dihydroxypyridine degradation to fumarate", "maleamate pathway", "2,5-dihydroxypyridine breakdown to fumarate", "pyridine-2,5-diol catabolic process to fumarate"], "types": ["T044"], "canonical_name": "2,5-dihydroxypyridine catabolic process to fumarate", "definition": "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate. [MetaCyc:PWY-722]"}
{"concept_id": "C1157154", "aliases": ["salicylic acid metabolism"], "types": ["T044"], "canonical_name": "salicylic acid metabolic process", "definition": "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid. [ISBN:0943088399]"}
{"concept_id": "C1157155", "aliases": ["sophorosyloxydocosanoate metabolism"], "types": ["T044"], "canonical_name": "sophorosyloxydocosanoate metabolic process", "definition": "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon. [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE]"}
{"concept_id": "C1157156", "aliases": ["alkaloid formation", "alkaloid anabolism", "alkaloid synthesis", "alkaloid biosynthesis"], "types": ["T044"], "canonical_name": "alkaloid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). [EC:1.1.1.51, GOC:lr, ISBN:0122146743]"}
{"concept_id": "C1157157", "aliases": ["dipyrromethane biosynthetic process", "dipyrrin synthesis", "dipyrrin biosynthesis", "dipyrrin anabolism", "dipyrromethane biosynthesis", "dipyrrin formation"], "types": ["T044"], "canonical_name": "dipyrrin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group. [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03]"}
{"concept_id": "C1157158", "aliases": ["nicotine anabolism", "nicotine biosynthesis", "nicotine formation", "nicotine synthesis"], "types": ["T044"], "canonical_name": "nicotine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. [GOC:sm, ISBN:0198547684]"}
{"concept_id": "C1157159", "aliases": ["purine alkaloid biosynthesis", "purine alkaloid anabolism", "purine alkaloid formation", "purine alkaloid synthesis"], "types": ["T044"], "canonical_name": "purine alkaloid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure. [GOC:ai]"}
{"concept_id": "C1157160", "aliases": ["tropane alkaloid synthesis", "tropane alkaloid anabolism", "tropane alkaloid biosynthesis", "tropane alkaloid formation"], "types": ["T044"], "canonical_name": "tropane alkaloid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1157161", "aliases": ["alkanesulfonate synthesis", "alkanesulphonate biosynthesis", "alkanesulphonate biosynthetic process", "alkanesulfonate formation", "alkanesulfonate anabolism", "alkanesulfonate biosynthesis"], "types": ["T044"], "canonical_name": "alkanesulfonate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. [GOC:ai]"}
{"concept_id": "C1157162", "aliases": ["aldonic acid formation", "aldonic acid synthesis", "aldonic acid anabolism", "aldonic acid biosynthesis"], "types": ["T044"], "canonical_name": "aldonic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. [ISBN:0198506732]"}
{"concept_id": "C1157164", "aliases": ["D-gluconate formation", "D-gluconate synthesis", "D-gluconate biosynthesis", "D-gluconate anabolism"], "types": ["T044"], "canonical_name": "D-gluconate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. [ISBN:0198506732]"}
{"concept_id": "C1157165", "aliases": ["ketogluconate synthesis", "ketogluconate formation", "ketogluconate anabolism", "ketogluconate biosynthesis"], "types": ["T044"], "canonical_name": "ketogluconate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group. [ISBN:0198506732]"}
{"concept_id": "C1157166", "aliases": ["L-idonate synthesis", "L-idonate biosynthesis", "L-idonate formation", "L-idonate anabolism"], "types": ["T044"], "canonical_name": "L-idonate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. [GOC:curators]"}
{"concept_id": "C1157167", "aliases": ["disaccharide synthesis", "disaccharide anabolism", "disaccharide formation", "disaccharide biosynthesis"], "types": ["T044"], "canonical_name": "disaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units. [GOC:ai]"}
{"concept_id": "C1157168", "aliases": ["lactose biosynthetic process", "lactose synthesis", "lactose anabolism", "lactose formation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose. [GOC:go_curators]", "canonical_name": "lactose biosynthesis"}
{"concept_id": "C1157169", "aliases": ["malt sugar biosynthesis", "maltose anabolism", "malt sugar biosynthetic process", "maltose biosynthesis", "maltose formation", "maltose synthesis"], "types": ["T044"], "canonical_name": "maltose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157170", "aliases": ["melibiose formation", "melibiose anabolism", "melibiose biosynthesis", "melibiose synthesis"], "types": ["T044"], "canonical_name": "melibiose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157171", "aliases": ["sucrose synthesis", "sucrose anabolism", "sucrose biosynthesis", "sucrose formation"], "types": ["T044"], "canonical_name": "sucrose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. [GOC:go_curators]"}
{"concept_id": "C1157172", "aliases": ["trehalose biosynthesis", "mycose biosynthetic process", "trehalose anabolism", "trehalose synthesis", "trehalose formation", "mykose biosynthesis", "mykose biosynthetic process", "mycose biosynthesis"], "types": ["T044"], "canonical_name": "trehalose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. [GOC:jl, ISBN:0028623819]"}
{"concept_id": "C1157173", "aliases": ["glucuronoside synthesis", "glucuronoside anabolism", "glucuronoside formation", "glucuronoside biosynthesis", "glucuronide biosynthetic process", "glucuronide biosynthesis"], "types": ["T044"], "canonical_name": "glucuronoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue. [ISBN:0198506732]"}
{"concept_id": "C1157174", "aliases": ["glycoside formation", "O-glycoside biosynthetic process", "O-glycoside anabolism", "O-glycoside formation", "glycoside synthesis", "O-glycoside biosynthesis", "glycoside biosynthesis", "O-glycoside synthesis", "glycoside anabolism"], "types": ["T044"], "canonical_name": "glycoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. [GOC:go_curators]"}
{"concept_id": "C1157175", "aliases": ["cyanogenic glycoside synthesis", "cyanogenic glycoside biosynthesis", "cyanogenic glycoside anabolism", "cyanogenic glycoside formation"], "types": ["T044"], "canonical_name": "cyanogenic glycoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. [ISBN:0198506732]"}
{"concept_id": "C1157176", "aliases": ["glycosinolate formation", "glycosinolate synthesis", "glycosinolate anabolism", "glycosinolate biosynthesis"], "types": ["T044"], "canonical_name": "glycosinolate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]"}
{"concept_id": "C1157177", "aliases": ["glucosinolate formation", "glucosinolate synthesis", "glucosinolate biosynthesis", "glucosinolate anabolism"], "types": ["T044"], "canonical_name": "glucosinolate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. [GOC:ai]"}
{"concept_id": "C1157179", "aliases": ["S-glycoside anabolism", "thioglycoside biosynthesis", "thioglycoside biosynthetic process", "S-glycoside synthesis", "S-glycoside formation", "S-glycoside biosynthesis"], "types": ["T044"], "canonical_name": "S-glycoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group. [ISBN:0198506732]"}
{"concept_id": "C1157180", "aliases": ["saponin formation", "saponin anabolism", "saponin synthesis", "saponin biosynthesis"], "types": ["T044"], "canonical_name": "saponin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection. [GOC:go_curators]"}
{"concept_id": "C1157181", "aliases": ["oligosaccharide synthesis", "oligosaccharide formation", "oligosaccharide biosynthesis", "oligosaccharide anabolism"], "types": ["T044"], "canonical_name": "oligosaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]"}
{"concept_id": "C1157182", "aliases": ["lipopolysaccharide core region formation", "lipopolysaccharide core region biosynthesis", "lipopolysaccharide core region synthesis", "LPS core region biosynthetic process", "lipopolysaccharide core region anabolism"], "types": ["T044"], "canonical_name": "lipopolysaccharide core region biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. [ISBN:0198506732]"}
{"concept_id": "C1157183", "aliases": [], "types": ["T044"], "definition": "A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions. [ISBN:0582015952]", "canonical_name": "photosynthesis, dark reaction"}
{"concept_id": "C1157184", "aliases": [], "types": ["T044"], "canonical_name": "C4 photosynthesis", "definition": "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch. [ISBN:0816017360]"}
{"concept_id": "C1157185", "aliases": [], "types": ["T044"], "canonical_name": "NAD-malic enzyme C4 photosynthesis", "definition": "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme. [PMID:11788762]"}
{"concept_id": "C1157186", "aliases": [], "types": ["T044"], "canonical_name": "NADP-malic enzyme C4 photosynthesis", "definition": "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme. [PMID:11788762]"}
{"concept_id": "C1157187", "aliases": [], "types": ["T044"], "canonical_name": "PEP carboxykinase C4 photosynthesis", "definition": "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK). [PMID:11788762]"}
{"concept_id": "C1157188", "aliases": [], "types": ["T044"], "definition": "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis. [ISBN:0582015952]", "canonical_name": "CAM photosynthesis"}
{"concept_id": "C1157189", "aliases": ["Calvin cycle"], "types": ["T044"], "definition": "The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. [ISBN:0198547684]", "canonical_name": "reductive pentose-phosphate cycle"}
{"concept_id": "C1157190", "aliases": ["polysaccharide anabolism", "glycan biosynthesis", "polysaccharide synthesis", "glycan biosynthetic process", "polysaccharide formation", "polysaccharide biosynthesis"], "types": ["T044"], "canonical_name": "polysaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:go_curators]"}
{"concept_id": "C1157191", "aliases": ["alginate biosynthetic process", "alginic acid biosynthesis", "alginic acid anabolism", "alginic acid synthesis", "alginate biosynthesis", "alginic acid formation"], "types": ["T044"], "canonical_name": "alginic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). [ISBN:0198506732]"}
{"concept_id": "C1157192", "aliases": ["chitin biosynthesis", "beta-1,4-linked N-acetylglucosamine biosynthetic process", "chitin synthesis", "chitin anabolism", "beta-1,4-linked N-acetylglucosamine biosynthesis", "chitin formation"], "types": ["T044"], "canonical_name": "chitin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157193", "aliases": ["cuticle chitin anabolism", "cuticle chitin synthesis", "cuticle chitin biosynthesis", "cuticle chitin formation"], "types": ["T044"], "canonical_name": "cuticle chitin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. [GOC:ai]"}
{"concept_id": "C1157194", "aliases": ["colanic acid anabolism", "colanic acid biosynthesis", "M antigen biosynthesis", "colanic acid synthesis", "colanic acid formation", "M antigen biosynthetic process"], "types": ["T044"], "canonical_name": "colanic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide. [GOC:ai]"}
{"concept_id": "C1157195", "aliases": ["enterobacterial common antigen synthesis", "enterobacterial common antigen formation", "enterobacterial common antigen anabolism", "enterobacterial common antigen biosynthesis"], "types": ["T044"], "canonical_name": "enterobacterial common antigen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. [GOC:ma]"}
{"concept_id": "C1157196", "aliases": ["extracellular polysaccharide biosynthesis", "extracellular polysaccharide anabolism", "extracellular polysaccharide formation", "extracellular polysaccharide synthesis"], "types": ["T044"], "canonical_name": "extracellular polysaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. [GOC:ai, GOC:go_curators]"}
{"concept_id": "C1157197", "aliases": ["GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation", "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism", "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis", "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis"], "types": ["T044"], "canonical_name": "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate. [GOC:ai]"}
{"concept_id": "C1157198", "aliases": ["glucan synthesis", "glucan biosynthesis", "glucan formation", "glucan anabolism"], "types": ["T044"], "canonical_name": "glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. [GOC:go_curators]"}
{"concept_id": "C1157199", "aliases": ["beta-1,3 glucan biosynthetic process", "1,3-beta-glucan biosynthesis", "1,3-beta-glucan formation", "beta-1,3 glucan biosynthesis", "1,3-beta-D-glucan biosynthetic process", "1,3-beta-glucan anabolism", "beta-1,3 glucan synthesis", "beta-1,3 glucan formation", "beta-1,3 glucan anabolism", "1,3-beta-glucan synthesis"], "types": ["T044"], "canonical_name": "(1->3)-beta-D-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds. [GOC:ai]"}
{"concept_id": "C1157200", "aliases": ["1,6-beta-glucan synthesis", "beta-1,6 glucan synthesis", "1,6-beta-glucan biosynthesis", "1,6-beta-glucan anabolism", "beta-1,6 glucan anabolism", "beta-1,6 glucan biosynthesis", "1,6-beta-glucan biosynthetic process", "beta-1,6 glucan formation", "1,6-beta-glucan formation", "beta-1,6 glucan biosynthetic process"], "types": ["T044"], "canonical_name": "(1->6)-beta-D-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans. [GOC:ai]"}
{"concept_id": "C1157201", "aliases": ["cellulose formation", "cellulose anabolism", "cellulose biosynthesis", "cellulose synthesis"], "types": ["T044"], "canonical_name": "cellulose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157202", "aliases": ["glycogen formation", "glycogen anabolism", "glycogen biosynthesis", "glycogen synthesis"], "types": ["T044"], "canonical_name": "glycogen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. [ISBN:0198506732]"}
{"concept_id": "C1157203", "aliases": ["regulation of glycogen formation", "regulation of glycogen synthesis", "regulation of glycogen anabolism", "regulation of glycogen biosynthesis"], "types": ["T044"], "canonical_name": "regulation of glycogen biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. [GOC:go_curators]"}
{"concept_id": "C1157204", "aliases": ["negative regulation of glycogen formation", "down-regulation of glycogen biosynthetic process", "down regulation of glycogen biosynthetic process", "negative regulation of glycogen biosynthesis", "negative regulation of glycogen anabolism", "downregulation of glycogen biosynthetic process", "negative regulation of glycogen synthesis"], "types": ["T043"], "canonical_name": "negative regulation of glycogen biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. [GOC:go_curators]"}
{"concept_id": "C1157205", "aliases": ["positive regulation of glycogen biosynthesis", "positive regulation of glycogen formation", "up regulation of glycogen biosynthetic process", "up-regulation of glycogen biosynthetic process", "positive regulation of glycogen anabolism", "positive regulation of glycogen synthesis", "upregulation of glycogen biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of glycogen biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. [GOC:go_curators]"}
{"concept_id": "C1157206", "aliases": ["starch synthesis", "starch anabolism", "starch formation", "starch biosynthesis"], "types": ["T044"], "canonical_name": "starch biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants. [GOC:ai]"}
{"concept_id": "C1157207", "aliases": ["heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism", "heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis", "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis", "heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis", "heparan sulfate proteoglycan formation, polysaccharide chain formation", "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process", "heparan sulfate proteoglycan chain elongation"], "types": ["T044"], "canonical_name": "heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan. [GOC:ai]"}
{"concept_id": "C1157208", "aliases": ["K antigen anabolism", "K antigen biosynthesis", "K antigen synthesis", "K antigen formation"], "types": ["T044"], "canonical_name": "K antigen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens. [ISBN:0198506732]"}
{"concept_id": "C1157209", "aliases": ["lipopolysaccharide synthesis", "lipopolysaccharide biosynthetic process", "lipopolysaccharide biosynthesis", "lipopolysaccharide anabolism", "LPS biosynthetic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. [GOC:ai, GOC:mr]", "canonical_name": "lipopolysaccharide formation"}
{"concept_id": "C1157210", "aliases": ["KDO biosynthesis", "ketodeoxyoctanoate biosynthetic process", "keto-3-deoxy-D-manno-octulosonic acid biosynthesis", "keto-3-deoxy-D-manno-octulosonic acid formation", "KDO biosynthetic process", "keto-3-deoxy-D-manno-octulosonic acid synthesis", "keto-3-deoxy-D-manno-octulosonic acid anabolism"], "types": ["T044"], "canonical_name": "keto-3-deoxy-D-manno-octulosonic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria. [ISBN:0198506732]"}
{"concept_id": "C1157211", "aliases": ["lipid A biosynthesis", "lipid A anabolism", "lipid A synthesis", "lipid A formation"], "types": ["T044"], "canonical_name": "lipid A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. [ISBN:0198506732, PMID:20974832, PMID:22216004]"}
{"concept_id": "C1157212", "aliases": ["O antigen anabolism", "O antigen biosynthesis", "O antigen synthesis", "O antigen formation"], "types": ["T044"], "canonical_name": "O antigen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide. [ISBN:0198506732]"}
{"concept_id": "C1157213", "aliases": ["mannan anabolism", "mannan formation", "mannan synthesis", "mannan biosynthesis"], "types": ["T044"], "canonical_name": "mannan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. [ISBN:0198506732]"}
{"concept_id": "C1157214", "aliases": ["pectin anabolism", "pectin formation", "pectin synthesis", "pectin biosynthesis"], "types": ["T044"], "canonical_name": "pectin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. [GOC:go_curators, PMID:11931668]"}
{"concept_id": "C1157215", "aliases": ["xylan synthesis", "xylan biosynthesis", "xylan anabolism", "xylan formation"], "types": ["T044"], "canonical_name": "xylan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone. [GOC:go_curators, PMID:11931668]"}
{"concept_id": "C1157216", "aliases": ["proteoglycan biosynthesis", "proteoglycan formation", "proteoglycan synthesis", "proteoglycan anabolism"], "types": ["T044"], "canonical_name": "proteoglycan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157217", "aliases": ["heparan sulphate proteoglycan biosynthesis", "heparan sulfate proteoglycan biosynthesis", "heparan sulfate proteoglycan formation", "heparan sulphate proteoglycan biosynthetic process", "heparan sulfate proteoglycan synthesis", "heparan sulfate proteoglycan anabolism"], "types": ["T044"], "canonical_name": "heparan sulfate proteoglycan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]"}
{"concept_id": "C1157218", "aliases": ["heparan sulfate proteoglycan formation, enzymatic modification", "heparan sulphate proteoglycan biosynthesis, enzymatic modification", "heparan sulfate proteoglycan synthesis, enzymatic modification", "heparan sulphate proteoglycan biosynthetic process, enzymatic modification", "heparan sulfate proteoglycan anabolism, enzymatic modification"], "types": ["T044"], "canonical_name": "heparan sulfate proteoglycan biosynthetic process, enzymatic modification", "definition": "The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization. [ISBN:0815316194]"}
{"concept_id": "C1157219", "aliases": ["heparan sulfate proteoglycan synthesis, linkage to polypeptide", "heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide", "heparan sulfate proteoglycan formation, linkage to polypeptide", "heparan sulphate proteoglycan biosynthesis, linkage to polypeptide", "heparan sulfate proteoglycan anabolism, linkage to polypeptide"], "types": ["T044"], "canonical_name": "heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide", "definition": "The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan. [ISBN:0815316194]"}
{"concept_id": "C1157220", "aliases": ["coenzyme and prosthetic group biosynthetic process"], "types": ["T044"], "canonical_name": "coenzyme and prosthetic group biosynthesis", "definition": "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes and prosthetic groups. [GOC:ai]"}
{"concept_id": "C1157222", "aliases": ["2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation", "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis", "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism", "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis"], "types": ["T044"], "canonical_name": "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A. [GOC:ai]"}
{"concept_id": "C1157223", "aliases": ["ATP anabolism", "ATP biosynthesis", "ATP synthesis", "ATP formation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators, ISBN:0198506732]", "canonical_name": "ATP biosynthetic process"}
{"concept_id": "C1157224", "aliases": ["ADP phosphorylation"], "types": ["T044"], "canonical_name": "ATP generation from ADP", "definition": "The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. [GOC:ai]"}
{"concept_id": "C1157225", "aliases": [], "types": ["T044"], "canonical_name": "AMP phosphorylation", "definition": "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP. [GOC:ai]"}
{"concept_id": "C1157226", "aliases": [], "types": ["T044"], "canonical_name": "ATP regeneration"}
{"concept_id": "C1157228", "aliases": ["coenzyme A synthesis", "coenzyme A biosynthesis", "coenzyme A anabolism", "coenzyme A formation", "CoA biosynthesis"], "types": ["T044"], "canonical_name": "coenzyme A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [ISBN:0198547684]"}
{"concept_id": "C1157229", "aliases": ["coenzyme B synthesis", "coenzyme B anabolism", "coenzyme B formation", "coenzyme B biosynthesis"], "types": ["T044"], "canonical_name": "coenzyme B biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. [PMID:10940051]"}
{"concept_id": "C1157230", "aliases": ["coenzyme M anabolism", "coenzyme M formation", "coenzyme M biosynthesis", "coenzyme M synthesis"], "types": ["T044"], "canonical_name": "coenzyme M biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. [ISBN:0198547684]"}
{"concept_id": "C1157231", "aliases": ["pyrroloquinoline quinone synthesis", "pyrroloquinoline-quinone biosynthesis", "pyrroloquinoline quinone biosynthesis", "PQQ biosynthesis", "PQQ biosynthetic process", "pyrroloquinoline quinone formation", "pyrroloquinoline quinone anabolism", "coenzyme pyrroloquinoline-quinone biosynthetic process", "coenzyme pyrroloquinoline-quinone biosynthesis", "pyrroloquinoline-quinone biosynthetic process"], "types": ["T044"], "canonical_name": "pyrroloquinoline quinone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed. [PMID:7665488, RESID:AA0283]"}
{"concept_id": "C1157232", "aliases": ["oxidized flavin adenine dinucleotide biosynthesis", "FAD synthesis", "FAD biosynthesis", "oxidized flavin adenine dinucleotide biosynthetic process", "oxidized flavin-adenine dinucleotide biosynthetic process", "oxidized flavin-adenine dinucleotide biosynthesis", "FAD formation", "FAD anabolism"], "types": ["T044"], "canonical_name": "FAD biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide. [GOC:ai, PMID:20822113]"}
{"concept_id": "C1157233", "aliases": ["FMN anabolism", "FMN synthesis", "FMN formation", "FMN biosynthesis"], "types": ["T044"], "canonical_name": "FMN biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase. [GOC:ai]"}
{"concept_id": "C1157234", "aliases": ["glutathione anabolism", "glutathione synthesis", "glutathione formation", "glutathione biosynthesis"], "types": ["T044"], "canonical_name": "glutathione biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]"}
{"concept_id": "C1157236", "aliases": ["lipoic acid formation", "lipoic acid synthesis", "lipoic acid biosynthetic process", "lipoic acid anabolism", "lipoic acid biosynthesis", "lipoate formation", "lipoate anabolism", "lipoate synthesis", "lipoate biosynthesis"], "types": ["T044"], "canonical_name": "lipoate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1157237", "aliases": ["vitamin B5 biosynthetic process", "pantothenate biosynthesis", "pantothenate synthesis", "vitamin B5 biosynthesis", "pantothenate anabolism", "pantothenate formation"], "types": ["T044"], "canonical_name": "pantothenate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. [GOC:ai, ISBN:0721662544]"}
{"concept_id": "C1157238", "aliases": ["pyridine nucleotide formation", "pyridine nucleotide biosynthesis", "pyridine nucleotide synthesis", "pyridine nucleotide anabolism"], "types": ["T044"], "canonical_name": "pyridine nucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. [GOC:jl, GOC:pde, GOC:vw]"}
{"concept_id": "C1157240", "aliases": ["NADP (oxidized) biosynthesis", "oxidized NADP biosynthetic process", "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process", "oxidized NADP biosynthesis", "NADP formation", "nicotinamide adenine dinucleotide phosphate biosynthesis", "reduced NADP biosynthesis", "reduced nicotinamide adenine dinucleotide phosphate biosynthesis", "reduced NADP biosynthetic process", "NADP (oxidized) biosynthetic process", "NADP (reduced) biosynthetic process", "NADP anabolism", "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis", "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process", "nicotinamide adenine dinucleotide phosphate biosynthetic process", "NADP biosynthesis", "NADPH biosynthesis", "NADP (reduced) biosynthesis", "NADPH biosynthetic process", "NADP synthesis"], "types": ["T044"], "canonical_name": "NADP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH. [GOC:mah]"}
{"concept_id": "C1157241", "aliases": ["NAD (reduced) biosynthesis", "nicotinamide adenine dinucleotide biosynthesis", "reduced NAD biosynthetic process", "NAD (oxidized) biosynthesis", "NAD (oxidized) biosynthetic process", "NAD (reduced) biosynthetic process", "NAD synthesis", "NADH biosynthetic process", "oxidized NAD biosynthetic process", "reduced NAD biosynthesis", "NAD biosynthesis", "oxidized nicotinamide adenine dinucleotide biosynthesis", "oxidized nicotinamide adenine dinucleotide biosynthetic process", "NADH biosynthesis", "NAD anabolism", "reduced nicotinamide adenine dinucleotide biosynthesis", "reduced nicotinamide adenine dinucleotide biosynthetic process", "nicotinamide adenine dinucleotide biosynthetic process", "NAD formation", "oxidized NAD biosynthesis"], "types": ["T044"], "canonical_name": "NAD biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. [GOC:jl, ISBN:0618254153]"}
{"concept_id": "C1157242", "aliases": ["nicotinamide nucleotide anabolism", "nicotinamide nucleotide synthesis", "nicotinamide nucleotide biosynthesis", "nicotinamide nucleotide formation"], "types": ["T044"], "canonical_name": "nicotinamide nucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. [GOC:go_curators]"}
{"concept_id": "C1157243", "aliases": ["nicotinamide nucleotide anabolism from niacinamide", "nicotinamide nucleotide formation from niacinamide", "nicotinamide nucleotide synthesis from niacinamide"], "types": ["T044"], "canonical_name": "nicotinamide nucleotide biosynthetic process from niacinamide", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide. [GOC:go_curators]"}
{"concept_id": "C1157244", "aliases": ["nicotinate nucleotide synthesis", "nicotinate nucleotide biosynthesis", "nicotinate nucleotide formation", "nicotinate nucleotide anabolism"], "types": ["T044"], "canonical_name": "nicotinate nucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid). [GOC:go_curators]"}
{"concept_id": "C1157245", "aliases": ["nicotinate nucleotide biosynthesis, salvage pathway", "nicotinate nucleotide biosynthetic process, salvage pathway"], "types": ["T044"], "canonical_name": "nicotinate nucleotide salvage", "definition": "The generation of nicotinate nucleotide without de novo synthesis. [GOC:go_curators]"}
{"concept_id": "C1157246", "aliases": ["pyridoxine formation", "pyridoxine anabolism", "pyridoxine synthesis", "pyridoxine biosynthesis"], "types": ["T044"], "canonical_name": "pyridoxine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. [GOC:ai]"}
{"concept_id": "C1157248", "aliases": ["ubiquinone biosynthesis", "coenzyme Q biosynthetic process", "coenzyme Q biosynthesis", "ubiquinone formation", "ubiquinone anabolism", "ubiquinone synthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. [GOC:mah]", "canonical_name": "ubiquinone biosynthetic process"}
{"concept_id": "C1157249", "aliases": ["vitamin K anabolism", "vitamin K synthesis", "vitamin K biosynthesis", "vitamin K formation"], "types": ["T044"], "canonical_name": "vitamin K biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]"}
{"concept_id": "C1157250", "aliases": ["phylloquinone synthesis", "phylloquinone anabolism", "phytylmenaquinone biosynthetic process", "vitamin K1 biosynthesis", "phytomenadione biosynthetic process", "phytylmenaquinone biosynthesis", "vitamin K1 biosynthetic process", "phylloquinone formation", "phytonadione biosynthetic process", "phytonadione biosynthesis", "phytomenadione biosynthesis", "phylloquinone biosynthesis"], "types": ["T044"], "canonical_name": "phylloquinone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]"}
{"concept_id": "C1157251", "aliases": ["menaquinone biosynthesis", "vitamin K2 biosynthetic process", "menatetrenone biosynthetic process", "multiprenylmenaquinone biosynthetic process", "menaquinone synthesis", "multiprenylmenaquinone biosynthesis", "menatetrenone biosynthesis", "menaquinone anabolism", "vitamin K2 biosynthesis", "menaquinone formation"], "types": ["T044"], "canonical_name": "menaquinone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]"}
{"concept_id": "C1157252", "aliases": ["thiamin diphosphate biosynthetic process", "thiamine pyrophosphate biosynthesis", "thiamine diphosphate formation", "TPP biosynthetic process", "thiamine diphosphate synthesis", "thiamin pyrophosphate biosynthetic process", "thiamine diphosphate biosynthesis", "thiamine pyrophosphate biosynthetic process", "thiamin pyrophosphate biosynthesis", "thiamine diphosphate anabolism", "TPP biosynthesis"], "types": ["T044"], "canonical_name": "thiamine diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. [GOC:jl, ISBN:0140512713]"}
{"concept_id": "C1157253", "aliases": ["corrin formation", "corrin biosynthesis", "corrin anabolism", "corrin synthesis"], "types": ["T044"], "canonical_name": "corrin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule. [GOC:ai]"}
{"concept_id": "C1157254", "aliases": ["chlorophyll synthesis", "chlorophyll anabolism", "chlorophyll formation", "chlorophyll biosynthesis"], "types": ["T044"], "canonical_name": "chlorophyll biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. [GOC:jl]"}
{"concept_id": "C1157255", "aliases": ["bacteriochlorophyll synthesis", "bacteriochlorophyll anabolism", "bacteriochlorophyll biosynthesis", "bacteriochlorophyll formation"], "types": ["T044"], "canonical_name": "bacteriochlorophyll biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157256", "aliases": ["haem A biosynthetic process", "haem A biosynthesis", "heme A formation", "heme A synthesis", "heme A biosynthesis", "heme A anabolism"], "types": ["T044"], "canonical_name": "heme A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3. [GOC:ai, PMID:11788607]"}
{"concept_id": "C1157257", "aliases": ["protoheme biosynthesis", "protoheme biosynthetic process", "heme B biosynthesis", "heme B anabolism", "haem B biosynthetic process", "haem B biosynthesis", "heme B synthesis", "heme B formation"], "types": ["T044"], "canonical_name": "heme B biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of heme B, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. [GOC:yaf, PMID:29414780, UniPathway:UPA00252]"}
{"concept_id": "C1157258", "aliases": ["haem C biosynthesis", "heme C anabolism", "haem C biosynthetic process", "heme C formation", "heme C synthesis", "heme C biosynthesis"], "types": ["T044"], "canonical_name": "heme C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f. [GOC:curators, PubChem_Compound:122208]"}
{"concept_id": "C1157259", "aliases": ["protoporphyrinogen IX formation", "protoporphyrinogen IX synthesis", "protoporphyrinogen IX biosynthesis", "protoporphyrinogen IX anabolism"], "types": ["T044"], "canonical_name": "protoporphyrinogen IX biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. [GOC:go_curators]"}
{"concept_id": "C1157260", "aliases": ["siroheme biosynthesis", "siroheme synthesis", "siroheme formation", "sirohaem biosynthetic process", "siroheme anabolism", "sirohaem biosynthesis"], "types": ["T044"], "canonical_name": "siroheme biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. [ISBN:0198506732]"}
{"concept_id": "C1157261", "aliases": ["uroporphyrinogen III formation", "uroporphyrinogen III biosynthesis", "uroporphyrinogen III synthesis", "uroporphyrinogen III anabolism"], "types": ["T044"], "canonical_name": "uroporphyrinogen III biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. [GOC:ai]"}
{"concept_id": "C1157262", "aliases": ["biosynthesis of protoporphyrin IX via succinyl-CoA", "biosynthetic process of protoporphyrin IX via succinyl-CoA", "biosynthetic process of protoporphyrin IX via succinyl CoA", "biosynthesis of protoporphyrin IX via succinyl CoA", "succinyl CoA pathway"], "types": ["T044"], "canonical_name": "succinyl-CoA pathway", "definition": "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX. [GOC:isa_complete, ISBN:0879010479]"}
{"concept_id": "C1157263", "aliases": ["cobalamin synthesis", "cobalamin biosynthesis", "cobalamin formation", "vitamin B12 biosynthetic process", "cobalamin anabolism", "vitamin B12 biosynthesis"], "types": ["T044"], "canonical_name": "cobalamin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157264", "aliases": ["aerobic vitamin B12 biosynthesis", "cobalamin biosynthetic process, aerobic", "aerobic vitamin B12 biosynthetic process", "aerobic cobalamin formation", "aerobic cobalamin synthesis", "aerobic cobalamin anabolism", "vitamin B12 biosynthetic process, aerobic", "vitamin B12 biosynthesis, aerobic", "aerobic cobalamin biosynthesis", "cobalamin biosynthesis, aerobic"], "types": ["T044"], "canonical_name": "aerobic cobalamin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen. [GOC:go_curators]"}
{"concept_id": "C1157265", "aliases": ["anaerobic cobalamin synthesis", "vitamin B12 biosynthetic process, anaerobic", "anaerobic cobalamin biosynthesis", "anaerobic cobalamin formation", "anaerobic vitamin B12 biosynthetic process", "anaerobic cobalamin anabolism", "anaerobic vitamin B12 biosynthesis", "vitamin B12 biosynthesis, anaerobic", "cobalamin biosynthesis, anaerobic", "cobalamin biosynthetic process, anaerobic"], "types": ["T044"], "canonical_name": "anaerobic cobalamin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen. [GOC:go_curators]"}
{"concept_id": "C1157266", "aliases": ["siderophore anabolism", "siderophore synthesis", "siderophore formation", "siderophore biosynthesis"], "types": ["T044"], "canonical_name": "siderophore biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. [PMID:20376388]"}
{"concept_id": "C1157267", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymate-containing siderophore biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid. Hydroxamate is one of the three major chemical groups incorporated into siderophore structures with catechol and a-hydroxycarboxylate, each having a high selectivity for iron(3+). [PMID:20376388]"}
{"concept_id": "C1157268", "aliases": ["cuticle biosynthetic process", "cuticle synthesis", "cuticle biosynthesis", "cuticle formation", "cuticle anabolism"], "types": ["T040"], "canonical_name": "cuticle development", "definition": "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss. [ISBN:0192800825]"}
{"concept_id": "C1157270", "aliases": ["chitin-based cuticle synthesis", "chitin-based cuticle biosynthetic process", "chitin-based cuticle formation", "chitin-based cuticle anabolism"], "types": ["T040"], "canonical_name": "chitin-based cuticle development", "definition": "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu]"}
{"concept_id": "C1157271", "aliases": ["adult chitin-based cuticle anabolism", "adult chitin-based cuticle synthesis", "adult chitin-based cuticle biosynthetic process", "adult chitin-based cuticle formation"], "types": ["T044"], "canonical_name": "adult chitin-based cuticle development", "definition": "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1157272", "aliases": ["chitin-based cuticle development during molting"], "types": ["T040"], "canonical_name": "cuticle development involved in chitin-based cuticle molting cycle", "definition": "The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster. [GOC:dph, GOC:jl, GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C1157273", "aliases": [], "types": ["T044"], "canonical_name": "larval chitin-based cuticle development", "definition": "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1157274", "aliases": [], "types": ["T044"], "canonical_name": "pupal chitin-based cuticle development", "definition": "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1157275", "aliases": [], "types": ["T044"], "canonical_name": "chitin-based embryonic cuticle biosynthetic process", "definition": "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu, PMID:12019232]"}
{"concept_id": "C1157276", "aliases": ["collagen and cuticulin-based cuticle synthesis", "collagen and cuticulin-based cuticle anabolism", "collagen and cuticulin-based cuticle biosynthetic process", "collagen and cuticulin-based cuticle formation"], "types": ["T040"], "canonical_name": "collagen and cuticulin-based cuticle development", "definition": "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans. [GOC:mtg_sensu]"}
{"concept_id": "C1157277", "aliases": [], "types": ["T040"], "canonical_name": "collagen and cuticulin-based cuticle development during molting"}
{"concept_id": "C1157279", "aliases": ["cuticle hydrocarbon synthesis", "cuticle hydrocarbon formation", "cuticle hydrocarbon biosynthesis", "cuticle hydrocarbon anabolism"], "types": ["T044"], "canonical_name": "cuticle hydrocarbon biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss. [GOC:ai]"}
{"concept_id": "C1157280", "aliases": ["deoxyribonucleoside anabolism", "deoxyribonucleoside synthesis", "deoxyribonucleoside biosynthesis", "deoxyribonucleoside formation"], "types": ["T044"], "canonical_name": "deoxyribonucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1157281", "aliases": ["purine deoxyribonucleoside anabolism", "purine deoxyribonucleoside synthesis", "purine deoxyribonucleoside formation", "purine deoxyribonucleoside biosynthesis"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1157282", "aliases": ["deoxyadenosine formation", "deoxyadenosine biosynthesis", "deoxyadenosine anabolism", "deoxyadenosine synthesis"], "types": ["T044"], "canonical_name": "deoxyadenosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA. [GOC:go_curators]"}
{"concept_id": "C1157283", "aliases": ["deoxyguanosine formation", "deoxyguanosine biosynthesis", "deoxyguanosine anabolism", "deoxyguanosine synthesis"], "types": ["T044"], "canonical_name": "deoxyguanosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. [GOC:jl]"}
{"concept_id": "C1157284", "aliases": ["pyrimidine deoxyribonucleoside biosynthesis", "pyrimidine deoxyribonucleoside synthesis", "pyrimidine deoxyribonucleoside formation", "pyrimidine deoxyribonucleoside anabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1157285", "aliases": ["deoxycytidine synthesis", "deoxycytidine formation", "deoxycytidine anabolism", "deoxycytidine biosynthesis"], "types": ["T044"], "canonical_name": "deoxycytidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. [GOC:go_curators]"}
{"concept_id": "C1157286", "aliases": ["deoxyinosine anabolism", "deoxyinosine biosynthesis", "deoxyinosine synthesis", "deoxyinosine formation"], "types": ["T044"], "canonical_name": "deoxyinosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside. [GOC:go_curators]"}
{"concept_id": "C1157287", "aliases": ["deoxyuridine formation", "deoxyuridine biosynthesis", "deoxyuridine synthesis", "deoxyuridine anabolism"], "types": ["T044"], "canonical_name": "deoxyuridine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA. [GOC:go_curators]"}
{"concept_id": "C1157288", "aliases": ["thymidine anabolism", "thymidine synthesis", "deoxyribosylthymine biosynthetic process", "thymidine biosynthesis", "deoxyribosylthymine biosynthesis", "thymidine formation"], "types": ["T044"], "canonical_name": "thymidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. [GOC:go_curators]"}
{"concept_id": "C1157289", "aliases": ["glycerol ether anabolism", "glycerol ether formation", "glycerol ether biosynthesis", "glycerol ether synthesis"], "types": ["T044"], "canonical_name": "glycerol ether biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. [GOC:ai]"}
{"concept_id": "C1157290", "aliases": ["ether lipid biosynthesis", "ether lipid anabolism", "ether lipid formation", "ether lipid synthesis"], "types": ["T044"], "canonical_name": "ether lipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. [GOC:ma, ISBN:0198547684, PMID:15337120]"}
{"concept_id": "C1157291", "aliases": ["heterocycle synthesis", "heterocycle biosynthesis", "heterocycle formation", "heterocycle anabolism"], "types": ["T044"], "canonical_name": "heterocycle biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). [ISBN:0198547684]"}
{"concept_id": "C1157292", "aliases": ["oxazole or thiazole anabolism", "oxazole or thiazole synthesis", "oxazole or thiazole formation", "oxazole or thiazole biosynthesis"], "types": ["T044"], "canonical_name": "oxazole or thiazole biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position. [GOC:curators]"}
{"concept_id": "C1157293", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via an oxazole or thiazole", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. [GOC:jsg]"}
{"concept_id": "C1157294", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via glycine oxazolecarboxylic acid", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation. [RESID:AA0240]"}
{"concept_id": "C1157295", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via glycine thiazolecarboxylic acid", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. [RESID:AA0241]"}
{"concept_id": "C1157296", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-cysteine oxazolecarboxylic acid", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation. [PMID:8895467, RESID:AA0238]"}
{"concept_id": "C1157297", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-cysteine oxazolinecarboxylic acid", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue. [RESID:AA0239]"}
{"concept_id": "C1157298", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-cysteine thiazolecarboxylic acid", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. [RESID:AA0244]"}
{"concept_id": "C1157299", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-lysine thiazolecarboxylic acid", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. [RESID:AA0245]"}
{"concept_id": "C1157300", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-phenylalanine thiazolecarboxylic acid", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. [RESID:AA0243]"}
{"concept_id": "C1157301", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-serine thiazolecarboxylic acid", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. [RESID:AA0242]"}
{"concept_id": "C1157302", "aliases": ["androgen synthesis", "androgen anabolism", "androgen formation", "androgen biosynthesis"], "types": ["T044"], "canonical_name": "androgen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]"}
{"concept_id": "C1157303", "aliases": ["auxin anabolism", "auxin synthesis", "auxin formation", "auxin biosynthesis"], "types": ["T044"], "canonical_name": "auxin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. [GOC:lm, GOC:lr, ISBN:0122146743]"}
{"concept_id": "C1157304", "aliases": ["C21-steroid hormone anabolism", "C21-steroid hormone synthesis", "C21-steroid hormone biosynthesis", "C21-steroid hormone formation"], "types": ["T044"], "canonical_name": "C21-steroid hormone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. [GOC:ai]"}
{"concept_id": "C1157305", "aliases": ["progesterone anabolism", "progesterone formation", "progesterone synthesis", "progesterone biosynthesis"], "types": ["T044"], "canonical_name": "progesterone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/]"}
{"concept_id": "C1157306", "aliases": ["ecdysteroid formation", "ecdysteroid anabolism", "ecdysteroid biosynthesis", "ecdysteroid synthesis"], "types": ["T044"], "canonical_name": "ecdysteroid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. [GOC:go_curators]"}
{"concept_id": "C1157307", "aliases": ["regulation of ecdysteroid biosynthesis", "regulation of ecdysteroid synthesis", "regulation of ecdysteroid anabolism", "regulation of ecdysteroid formation"], "types": ["T040"], "canonical_name": "regulation of ecdysteroid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. [GOC:go_curators]"}
{"concept_id": "C1157308", "aliases": ["negative regulation of ecdysteroid anabolism", "down-regulation of ecdysteroid biosynthetic process", "negative regulation of ecdysteroid synthesis", "negative regulation of ecdysteroid biosynthesis", "down regulation of ecdysteroid biosynthetic process", "downregulation of ecdysteroid biosynthetic process", "negative regulation of ecdysteroid formation"], "types": ["T043"], "canonical_name": "negative regulation of ecdysteroid biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. [GOC:go_curators]"}
{"concept_id": "C1157309", "aliases": ["positive regulation of ecdysteroid synthesis", "up-regulation of ecdysteroid biosynthetic process", "positive regulation of ecdysteroid biosynthesis", "positive regulation of ecdysteroid anabolism", "upregulation of ecdysteroid biosynthetic process", "up regulation of ecdysteroid biosynthetic process", "positive regulation of ecdysteroid formation"], "types": ["T043"], "canonical_name": "positive regulation of ecdysteroid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. [GOC:go_curators]"}
{"concept_id": "C1157310", "aliases": ["estrogen biosynthesis", "oestrogen biosynthesis", "oestrogen biosynthetic process", "estrogen synthesis", "estrogen anabolism", "estrogen formation"], "types": ["T044"], "canonical_name": "estrogen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]"}
{"concept_id": "C1157311", "aliases": ["glucocorticoid biosynthesis", "glucocorticoid formation", "glucocorticoid synthesis", "glucocorticoid anabolism"], "types": ["T044"], "canonical_name": "glucocorticoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]"}
{"concept_id": "C1157312", "aliases": ["juvenile hormone biosynthesis", "juvenile hormone anabolism", "juvenile hormone formation", "juvenile hormone synthesis"], "types": ["T044"], "canonical_name": "juvenile hormone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. [GOC:go_curators, ISBN:0198547684]"}
{"concept_id": "C1157313", "aliases": ["regulation of juvenile hormone biosynthesis", "regulation of juvenile hormone anabolism", "regulation of juvenile hormone formation", "regulation of juvenile hormone synthesis"], "types": ["T042"], "canonical_name": "regulation of juvenile hormone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1157314", "aliases": ["negative regulation of juvenile hormone biosynthesis", "down regulation of juvenile hormone biosynthetic process", "negative regulation of juvenile hormone anabolism", "downregulation of juvenile hormone biosynthetic process", "negative regulation of juvenile hormone formation", "negative regulation of juvenile hormone synthesis", "down-regulation of juvenile hormone biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of juvenile hormone biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1157315", "aliases": ["upregulation of juvenile hormone biosynthetic process", "positive regulation of juvenile hormone anabolism", "up-regulation of juvenile hormone biosynthetic process", "positive regulation of juvenile hormone biosynthesis", "positive regulation of juvenile hormone synthesis", "positive regulation of juvenile hormone formation", "up regulation of juvenile hormone biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of juvenile hormone biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1157316", "aliases": ["mineralocorticoid synthesis", "mineralocorticoid formation", "mineralocorticoid biosynthesis", "mineralocorticoid anabolism"], "types": ["T044"], "canonical_name": "mineralocorticoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]"}
{"concept_id": "C1157317", "aliases": ["ketone anabolism", "ketone formation", "ketone synthesis", "ketone biosynthesis"], "types": ["T044"], "canonical_name": "ketone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. [GOC:go_curators]"}
{"concept_id": "C1157318", "aliases": ["(+)-camphor anabolism", "(+)-camphor synthesis", "(+)-camphor biosynthesis", "(+)-camphor formation"], "types": ["T044"], "canonical_name": "(+)-camphor biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone. [GOC:ai]"}
{"concept_id": "C1157319", "aliases": ["acetoin formation", "acetoin biosynthesis", "acetoin anabolism", "acetoin synthesis"], "types": ["T044"], "canonical_name": "acetoin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone. [GOC:mlg]"}
{"concept_id": "C1157320", "aliases": ["icosanoid biosynthesis", "icosanoid anabolism", "icosanoid formation", "eicosanoid biosynthetic process", "eoxin biosynthesis", "eicosanoid biosynthesis", "icosanoid synthesis", "eoxin synthesis"], "types": ["T044"], "canonical_name": "icosanoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. [ISBN:0198506732]"}
{"concept_id": "C1157321", "aliases": ["leukotriene anabolism", "leukotriene biosynthesis", "leukotriene formation", "leukotriene synthesis"], "types": ["T044"], "canonical_name": "leukotriene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:go_curators]"}
{"concept_id": "C1157322", "aliases": [], "types": ["T044"], "canonical_name": "lipoxygenase pathway", "definition": "The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. [GOC:mah, PMID:17163881]"}
{"concept_id": "C1157323", "aliases": ["prostanoid formation", "prostanoid anabolism", "prostanoid biosynthesis", "prostanoid synthesis"], "types": ["T044"], "canonical_name": "prostanoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. [GOC:ai]"}
{"concept_id": "C1157324", "aliases": ["prostaglandin formation", "prostaglandin biosynthesis", "prostaglandin synthesis", "prostaglandin anabolism"], "types": ["T044"], "canonical_name": "prostaglandin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. [GOC:ai]"}
{"concept_id": "C1157325", "aliases": [], "types": ["T044"], "canonical_name": "cyclooxygenase pathway", "definition": "The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. [PMID:19854273]"}
{"concept_id": "C1157326", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid elongation", "definition": "The elongation of a fatty acid chain by the sequential addition of two-carbon units. [ISBN:0716720094]"}
{"concept_id": "C1157327", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid elongation, saturated fatty acid", "definition": "Elongation of a saturated fatty acid chain. [GOC:mah]"}
{"concept_id": "C1157328", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid elongation, unsaturated fatty acid", "definition": "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced. [GOC:mah]"}
{"concept_id": "C1157329", "aliases": ["regulation of fatty acid anabolism", "regulation of fatty acid synthesis", "regulation of fatty acid biosynthesis", "regulation of fatty acid formation"], "types": ["T043"], "canonical_name": "regulation of fatty acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. [GOC:go_curators, GOC:jl]"}
{"concept_id": "C1157330", "aliases": ["down regulation of fatty acid biosynthetic process", "negative regulation of fatty acid biosynthesis", "negative regulation of fatty acid formation", "downregulation of fatty acid biosynthetic process", "negative regulation of fatty acid synthesis", "down-regulation of fatty acid biosynthetic process", "negative regulation of fatty acid anabolism"], "types": ["T043"], "canonical_name": "negative regulation of fatty acid biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. [GOC:go_curators]"}
{"concept_id": "C1157331", "aliases": ["up regulation of fatty acid biosynthetic process", "upregulation of fatty acid biosynthetic process", "up-regulation of fatty acid biosynthetic process", "positive regulation of fatty acid biosynthesis", "positive regulation of fatty acid synthesis", "positive regulation of fatty acid formation", "positive regulation of fatty acid anabolism"], "types": ["T043"], "canonical_name": "positive regulation of fatty acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. [GOC:go_curators]"}
{"concept_id": "C1157332", "aliases": ["glycerolipid biosynthesis", "glycerolipid anabolism", "glycerolipid formation", "glycerolipid synthesis"], "types": ["T044"], "canonical_name": "glycerolipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. [GOC:ai]"}
{"concept_id": "C1157333", "aliases": ["acylglycerol formation", "acylglycerol biosynthesis", "acylglycerol anabolism", "acylglycerol synthesis"], "types": ["T044"], "canonical_name": "acylglycerol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. [GOC:ai]"}
{"concept_id": "C1157334", "aliases": ["diacylglycerol formation", "diacylglycerol synthesis", "diacylglycerol biosynthesis", "diglyceride biosynthesis", "diacylglycerol anabolism"], "types": ["T044"], "canonical_name": "diacylglycerol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [GOC:curators]"}
{"concept_id": "C1157335", "aliases": ["CDP-diacylglycerol biosynthesis", "CDP-diacylglycerol synthesis", "CDP-diacylglycerol anabolism", "CDP-diacylglycerol formation"], "types": ["T044"], "canonical_name": "CDP-diacylglycerol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. [PMID:24533860]"}
{"concept_id": "C1157336", "aliases": ["monoglyceride biosynthetic process", "monoacylglycerol anabolism", "monoacylglycerol synthesis", "monoacylglycerol biosynthesis", "monoglyceride biosynthesis", "monoacylglycerol formation"], "types": ["T044"], "canonical_name": "monoacylglycerol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [ISBN:0198506732]"}
{"concept_id": "C1157337", "aliases": ["triglyceride synthesis", "triacylglycerol biosynthesis", "triglyceride anabolism", "triacylglycerol biosynthetic process", "triglyceride biosynthesis", "triglyceride formation"], "types": ["T044"], "canonical_name": "triglyceride biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol. [ISBN:0198506732]"}
{"concept_id": "C1157338", "aliases": ["2-methyl-1,3-butadiene biosynthetic process", "isoprenoid anabolism", "hemiterpene biosynthetic process", "2-methyl-1,3-butadiene biosynthesis", "isoprenoid formation", "isoprenoid biosynthesis", "isoprene biosynthetic process", "isoprenoid synthesis", "hemiterpene biosynthesis"], "types": ["T044"], "canonical_name": "isoprenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of isoprene, C5H8. [GOC:jl]"}
{"concept_id": "C1157339", "aliases": ["farnesyl diphosphate biosynthesis", "farnesyl diphosphate formation", "farnesyl diphosphate synthesis", "farnesyl diphosphate anabolism"], "types": ["T044"], "canonical_name": "farnesyl diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of farnesyl diphosphate. [GOC:jl]"}
{"concept_id": "C1157340", "aliases": ["IPP biosynthesis", "isopentenyl diphosphate synthesis", "IPP biosynthetic process", "isopentenyl pyrophosphate biosynthesis", "isopentenyl diphosphate anabolism", "isopentenyl diphosphate biosynthesis", "isopentenyl diphosphate biosynthetic process", "isopentenyl diphosphate formation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids. [GOC:jl, ISBN:0198506732]", "canonical_name": "isopentenyl pyrophosphate biosynthetic process"}
{"concept_id": "C1157342", "aliases": ["isopentenyl diphosphate biosynthesis, mevalonate-independent", "isopentenyl diphosphate biosynthetic process, mevalonate-independent", "mevalonate-independent isopentenyl diphosphate biosynthetic process", "mevalonate-independent isopentenyl diphosphate biosynthesis", "isopentenyl diphosphate biosynthesis, non-mevalonate pathway", "isopentenyl diphosphate formation, mevalonate-independent pathway", "isopentenyl diphosphate biosynthetic process via 1-deoxy-D-xylulose 5-phosphate", "non-MVA pathway", "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway", "isopentenyl diphosphate biosynthetic process, non-mevalonate pathway", "isopentenyl diphosphate anabolism, mevalonate-independent pathway", "isopentenyl diphosphate synthesis, mevalonate-independent pathway", "isopentenyl diphosphate biosynthetic process, MEP pathway"], "types": ["T044"], "canonical_name": "isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway", "definition": "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. [GOC:go_curators, MetaCyc:NONMEVIPP-PWY, PMID:18948055]"}
{"concept_id": "C1157343", "aliases": ["polyterpene biosynthesis"], "types": ["T044"], "canonical_name": "polyterpene biosynthetic process"}
{"concept_id": "C1157344", "aliases": ["terpenoid biosynthetic process", "terpenoid biosynthesis", "terpenoid anabolism", "terpenoid formation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. [GOC:ai]", "canonical_name": "terpenoid synthesis"}
{"concept_id": "C1157345", "aliases": ["diterpenoid formation", "diterpenoid synthesis", "diterpenoid biosynthesis", "diterpenoid anabolism"], "types": ["T044"], "canonical_name": "diterpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1157346", "aliases": ["gibberellic acid biosynthesis", "gibberellin biosynthesis", "gibberellic acid synthesis", "gibberellic acid biosynthetic process", "gibberellic acid formation", "gibberellic acid anabolism"], "types": ["T044"], "canonical_name": "gibberellin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators. [ISBN:0387969845]"}
{"concept_id": "C1157347", "aliases": ["monoterpenoid anabolism", "monoterpenoid biosynthesis", "monoterpenoid formation", "monoterpenoid synthesis"], "types": ["T044"], "canonical_name": "monoterpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton. [GOC:go_curators]"}
{"concept_id": "C1157348", "aliases": ["polyterpenoid biosynthesis", "polyterpenoid synthesis", "polyterpenoid anabolism", "polyterpenoid formation"], "types": ["T044"], "canonical_name": "polyterpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units. [GOC:go_curators]"}
{"concept_id": "C1157349", "aliases": ["sesquiterpenoid biosynthesis", "sesquiterpenoid synthesis", "sesquiterpenoid formation", "sesquiterpenoid anabolism"], "types": ["T044"], "canonical_name": "sesquiterpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units. [GOC:go_curators]"}
{"concept_id": "C1157350", "aliases": ["abscisic acid formation", "abscisic acid biosynthesis", "abscisic acid synthesis", "abscisic acid anabolism"], "types": ["T044"], "canonical_name": "abscisic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. [ISBN:0387969845]"}
{"concept_id": "C1157351", "aliases": ["tetraterpenoid biosynthesis", "tetraterpenoid synthesis", "tetraterpenoid anabolism", "tetraterpenoid formation"], "types": ["T044"], "canonical_name": "tetraterpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units. [GOC:go_curators]"}
{"concept_id": "C1157352", "aliases": ["carotenoid formation", "carotenoid anabolism", "carotenoid biosynthetic process", "carotenoid synthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. [GOC:go_curators]", "canonical_name": "carotenoid biosynthesis"}
{"concept_id": "C1157353", "aliases": ["carotene biosynthesis", "carotene anabolism", "carotene formation", "carotene synthesis"], "types": ["T044"], "canonical_name": "carotene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids. [GOC:go_curators]"}
{"concept_id": "C1157354", "aliases": ["xanthophyll biosynthesis", "xanthophyll formation", "xanthophyll synthesis", "xanthophyll anabolism"], "types": ["T044"], "canonical_name": "xanthophyll biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids. [GOC:go_curators]"}
{"concept_id": "C1157355", "aliases": ["triterpenoid anabolism", "triterpenoid synthesis", "triterpenoid biosynthesis", "triterpenoid formation"], "types": ["T044"], "canonical_name": "triterpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units. [GOC:go_curators]"}
{"concept_id": "C1157356", "aliases": ["pentacyclic triterpenoid anabolism", "pentacyclic triterpenoid synthesis", "pentacyclic triterpenoid biosynthesis", "pentacyclic triterpenoid formation"], "types": ["T044"], "canonical_name": "pentacyclic triterpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. [ISBN:0198506732]"}
{"concept_id": "C1157357", "aliases": ["hopanoid biosynthesis", "hopanoid formation", "hopanoid anabolism", "hopanoid synthesis"], "types": ["T044"], "canonical_name": "hopanoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. [ISBN:0198547684]"}
{"concept_id": "C1157358", "aliases": ["prenol anabolism", "prenol synthesis", "prenol biosynthesis", "prenol formation"], "types": ["T044"], "canonical_name": "prenol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail. [GOC:go_curators]"}
{"concept_id": "C1157359", "aliases": ["polyprenol formation", "polyprenol biosynthesis", "polyprenol synthesis", "polyprenol anabolism"], "types": ["T044"], "canonical_name": "polyprenol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. [GOC:go_curators, PMID:11108713]"}
{"concept_id": "C1157360", "aliases": ["dolichol anabolism", "dolichol synthesis", "dolichol formation", "dolichol biosynthesis"], "types": ["T044"], "canonical_name": "dolichol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. [ISBN:0198506732]"}
{"concept_id": "C1157361", "aliases": ["dolichyl diphosphate synthesis", "dolichyl diphosphate anabolism", "dolichyl diphosphate biosynthesis", "dolichyl diphosphate formation"], "types": ["T044"], "canonical_name": "dolichyl diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative. [ISBN:0198506732]"}
{"concept_id": "C1157362", "aliases": ["membrane lipid anabolism", "membrane lipid synthesis", "membrane lipid formation", "membrane lipid biosynthesis"], "types": ["T044"], "canonical_name": "membrane lipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. [GOC:ai]"}
{"concept_id": "C1157363", "aliases": ["glycolipid biosynthesis", "glycolipid formation", "glycolipid synthesis", "glycolipid anabolism"], "types": ["T044"], "canonical_name": "glycolipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). [GOC:go_curators]"}
{"concept_id": "C1157364", "aliases": ["galactolipid biosynthesis", "galactolipid anabolism", "galactolipid formation", "galactolipid synthesis"], "types": ["T044"], "canonical_name": "galactolipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. [ISBN:0198506732]"}
{"concept_id": "C1157365", "aliases": ["galactosylceramide anabolism", "galactosylceramide formation", "galactosylceramide biosynthesis", "galactosylceramide synthesis"], "types": ["T044"], "canonical_name": "galactosylceramide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. [GOC:ai]"}
{"concept_id": "C1157366", "aliases": ["glycosphingolipid synthesis", "glycosphingolipid formation", "glycosphingolipid biosynthesis", "glycosphingolipid anabolism"], "types": ["T044"], "canonical_name": "glycosphingolipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [GOC:go_curators]"}
{"concept_id": "C1157367", "aliases": ["ganglioside anabolism", "ganglioside biosynthesis", "ganglioside synthesis", "ganglioside biosynthetic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. [ISBN:0198506732]", "canonical_name": "ganglioside formation"}
{"concept_id": "C1157368", "aliases": ["lactosylceramide formation", "lactosylceramide anabolism", "lactosylceramide synthesis", "lactosylceramide biosynthesis"], "types": ["T044"], "canonical_name": "lactosylceramide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides. [ISBN:0198506732, ISBN:0471586501]"}
{"concept_id": "C1157369", "aliases": ["globoside synthesis", "globoside formation", "globoside biosynthesis", "globoside anabolism"], "types": ["T044"], "canonical_name": "globoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). [ISBN:0198506732]"}
{"concept_id": "C1157370", "aliases": ["GSI anchor anabolism", "GSI anchor formation", "GSI anchor synthesis", "GSI anchor biosynthesis"], "types": ["T044"], "canonical_name": "GSI anchor biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage. [GOC:go_curators, GOC:jsg]"}
{"concept_id": "C1157371", "aliases": ["GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine", "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine", "GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine"], "types": ["T044"], "canonical_name": "GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine", "definition": "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein. [RESID:AA0166]"}
{"concept_id": "C1157372", "aliases": ["glycosylceramide formation", "glycosylceramide synthesis", "glycosylceramide anabolism", "glycosylceramide biosynthesis"], "types": ["T044"], "canonical_name": "glycosylceramide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. [GOC:ai]"}
{"concept_id": "C1157373", "aliases": ["glucosylceramide synthesis", "glucosylceramide biosynthesis", "glucosylceramide anabolism", "glucosylceramide formation"], "types": ["T044"], "canonical_name": "glucosylceramide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. [GOC:ai]"}
{"concept_id": "C1157374", "aliases": ["regulation of glucosylceramide synthesis", "regulation of glucosylceramide biosynthesis", "regulation of glucosylceramide formation", "regulation of glucosylceramide anabolism"], "types": ["T044"], "canonical_name": "regulation of glucosylceramide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide. [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C1157375", "aliases": ["negative regulation of glucosylceramide formation", "down-regulation of glucosylceramide biosynthetic process", "down regulation of glucosylceramide biosynthetic process", "downregulation of glucosylceramide biosynthetic process", "negative regulation of glucosylceramide biosynthesis", "negative regulation of glucosylceramide synthesis", "negative regulation of glucosylceramide anabolism"], "types": ["T043"], "canonical_name": "negative regulation of glucosylceramide biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide. [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C1157376", "aliases": ["positive regulation of glucosylceramide biosynthesis", "positive regulation of glucosylceramide anabolism", "positive regulation of glucosylceramide formation", "up regulation of glucosylceramide biosynthetic process", "up-regulation of glucosylceramide biosynthetic process", "upregulation of glucosylceramide biosynthetic process", "positive regulation of glucosylceramide synthesis"], "types": ["T043"], "canonical_name": "positive regulation of glucosylceramide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide. [GOC:ai]"}
{"concept_id": "C1157377", "aliases": ["phospholipid biosynthesis", "phospholipid anabolism", "phospholipid formation", "phospholipid synthesis"], "types": ["T044"], "canonical_name": "phospholipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]"}
{"concept_id": "C1157378", "aliases": ["glycerophospholipid formation", "phosphoglyceride biosynthetic process", "glycerophospholipid synthesis", "glycerophospholipid anabolism", "glycerophospholipid biosynthesis", "phosphoglyceride biosynthesis"], "types": ["T044"], "canonical_name": "glycerophospholipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. [ISBN:0198506732]"}
{"concept_id": "C1157379", "aliases": ["phosphatidic acid synthesis", "phosphatidic acid formation", "phosphatidic acid anabolism", "phosphatidic acid biosynthesis"], "types": ["T044"], "canonical_name": "phosphatidic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [ISBN:0198506732]"}
{"concept_id": "C1157380", "aliases": ["phosphatidylcholine anabolism", "phosphatidylcholine synthesis", "phosphatidylcholine biosynthesis", "phosphatidylcholine biosynthetic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [ISBN:0198506732]", "canonical_name": "phosphatidylcholine formation"}
{"concept_id": "C1157381", "aliases": ["phosphatidylcholine biosynthesis from choline", "Kennedy pathway"], "types": ["T044"], "canonical_name": "CDP-choline pathway", "definition": "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. [ISBN:0471331309, MetaCyc:PWY3O-450]"}
{"concept_id": "C1157382", "aliases": ["phosphatidylglycerol synthesis", "phosphatidylglycerol biosynthesis", "phosphatidylglycerol formation", "phosphatidylglycerol anabolism"], "types": ["T044"], "canonical_name": "phosphatidylglycerol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. [ISBN:0198506732]"}
{"concept_id": "C1157383", "aliases": ["phosphatidylserine synthesis", "phosphatidylserine anabolism", "phosphatidylserine formation", "phosphatidylserine biosynthesis"], "types": ["T044"], "canonical_name": "phosphatidylserine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. [ISBN:0198506732]"}
{"concept_id": "C1157385", "aliases": ["glycosylphosphatidylinositol biosynthesis", "GPI anchor biosynthesis", "glycosylphosphatidylinositol biosynthetic process", "GPI anchor formation", "GPI anchor synthesis", "GPI anchor anabolism"], "types": ["T044"], "canonical_name": "GPI anchor biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. [GOC:go_curators, ISBN:0198547684]"}
{"concept_id": "C1157386", "aliases": [], "types": ["T044"], "canonical_name": "attachment of GPI anchor to protein", "definition": "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain. [ISBN:0879695595]"}
{"concept_id": "C1157387", "aliases": ["GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine", "GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine", "GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine"], "types": ["T044"], "canonical_name": "GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. [RESID:AA0163]"}
{"concept_id": "C1157388", "aliases": ["GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine", "GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine", "GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine"], "types": ["T044"], "canonical_name": "GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. [RESID:AA0158]"}
{"concept_id": "C1157389", "aliases": ["GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine", "GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine", "GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine"], "types": ["T044"], "canonical_name": "GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. [RESID:AA0159]"}
{"concept_id": "C1157390", "aliases": ["GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine", "GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine", "GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine"], "types": ["T044"], "canonical_name": "GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. [RESID:AA0160]"}
{"concept_id": "C1157391", "aliases": ["GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine", "GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine", "GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine"], "types": ["T044"], "canonical_name": "GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. [RESID:AA0161]"}
{"concept_id": "C1157392", "aliases": ["GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine", "GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine", "GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine"], "types": ["T044"], "canonical_name": "GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein. [RESID:AA0162]"}
{"concept_id": "C1157393", "aliases": ["preassembly of GPI anchor in endoplasmic reticulum membrane"], "types": ["T043"], "canonical_name": "preassembly of GPI anchor in ER membrane", "definition": "The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. [ISBN:0879695595]"}
{"concept_id": "C1157394", "aliases": ["phosphatidylinositol anabolism", "PtdIns biosynthetic process", "phosphatidylinositol formation", "phosphatidylinositol synthesis", "phosphatidylinositol biosynthesis", "phosphoinositide biosynthetic process", "PtdIns biosynthesis", "phosphoinositide biosynthesis"], "types": ["T044"], "canonical_name": "phosphatidylinositol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]"}
{"concept_id": "C1157395", "aliases": ["platelet activating factor formation", "PAF biosynthesis", "platelet activating factor synthesis", "platelet activating factor anabolism", "PAF biosynthetic process", "platelet activating factor biosynthesis"], "types": ["T044"], "canonical_name": "platelet activating factor biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. [ISBN:0198547684]"}
{"concept_id": "C1157396", "aliases": ["sphingomyelin formation", "sphingomyelin anabolism", "sphingomyelin synthesis", "sphingomyelin biosynthesis"], "types": ["T044"], "canonical_name": "sphingomyelin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]"}
{"concept_id": "C1157397", "aliases": ["sphingolipid anabolism", "sphingolipid synthesis", "sphingolipid biosynthesis", "sphingolipid formation"], "types": ["T044"], "canonical_name": "sphingolipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157398", "aliases": ["sphingoid formation", "sphingoid synthesis", "sphingoid anabolism", "sphingoid biosynthesis"], "types": ["T044"], "canonical_name": "sphingoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. [ISBN:0198506732]"}
{"concept_id": "C1157399", "aliases": ["ceramide biosynthesis", "ceramide anabolism", "ceramide synthesis", "ceramide formation"], "types": ["T044"], "canonical_name": "ceramide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. [GOC:ai]"}
{"concept_id": "C1157400", "aliases": ["sphinganine biosynthesis", "dihydrosphingosine biosynthesis", "dihydrosphingosine biosynthetic process", "sphinganine synthesis", "sphinganine anabolism", "sphinganine formation"], "types": ["T044"], "canonical_name": "sphinganine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol. [GOC:ai]"}
{"concept_id": "C1157401", "aliases": ["sphinganine-1-phosphate formation", "sphinganine-1-phosphate biosynthesis", "dihydrosphingosine-1-phosphate biosynthetic process", "sphinganine-1-phosphate synthesis", "dihydrosphingosine-1-phosphate biosynthesis", "sphinganine-1-phosphate anabolism"], "types": ["T044"], "canonical_name": "sphinganine-1-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. [GOC:ai]"}
{"concept_id": "C1157402", "aliases": ["neutral lipid synthesis", "neutral lipid formation", "neutral lipid anabolism", "neutral lipid biosynthesis"], "types": ["T044"], "canonical_name": "neutral lipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. [GOC:ai]"}
{"concept_id": "C1157403", "aliases": ["bile acid anabolism", "bile acid formation", "bile acid biosynthetic process", "bile acid synthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. [GOC:go_curators]", "canonical_name": "bile acid biosynthesis"}
{"concept_id": "C1157404", "aliases": ["phytosteroid formation", "phytosteroid anabolism", "phytosteroid synthesis", "phytosteroid biosynthesis"], "types": ["T044"], "canonical_name": "phytosteroid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi. [GOC:go_curators, GOC:mah, ISBN:0471331309]"}
{"concept_id": "C1157405", "aliases": ["brassinosteroid synthesis", "brassinosteroid formation", "brassinosteroid anabolism", "brassinosteroid biosynthesis"], "types": ["T044"], "canonical_name": "brassinosteroid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. [ISBN:0192801023]"}
{"concept_id": "C1157406", "aliases": ["sulpholipid biosynthetic process", "sulfolipid formation", "sulfolipid biosynthesis", "sulpholipid biosynthesis", "sulfolipid anabolism", "sulfolipid synthesis"], "types": ["T044"], "canonical_name": "sulfolipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid. [PMID:9751667]"}
{"concept_id": "C1157407", "aliases": ["macromolecule anabolism", "biopolymer biosynthetic process", "macromolecule biosynthesis", "macromolecule formation", "macromolecule synthesis"], "types": ["T044"], "canonical_name": "macromolecule biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:mah]"}
{"concept_id": "C1157408", "aliases": [], "types": ["T045"], "canonical_name": "alanyl-tRNA aminoacylation", "definition": "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157410", "aliases": [], "types": ["T045"], "canonical_name": "arginyl-tRNA aminoacylation", "definition": "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157411", "aliases": [], "types": ["T045"], "canonical_name": "asparaginyl-tRNA aminoacylation", "definition": "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157412", "aliases": [], "types": ["T045"], "canonical_name": "aspartyl-tRNA aminoacylation", "definition": "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA. [GOC:mah, ISBN:0716730510]"}
{"concept_id": "C1157413", "aliases": [], "types": ["T045"], "canonical_name": "cysteinyl-tRNA aminoacylation", "definition": "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157414", "aliases": [], "types": ["T045"], "canonical_name": "glutaminyl-tRNA aminoacylation", "definition": "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157415", "aliases": [], "types": ["T045"], "canonical_name": "glutamyl-tRNA aminoacylation", "definition": "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157416", "aliases": [], "types": ["T045"], "canonical_name": "glycyl-tRNA aminoacylation", "definition": "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157417", "aliases": [], "types": ["T045"], "canonical_name": "histidyl-tRNA aminoacylation", "definition": "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157418", "aliases": [], "types": ["T045"], "canonical_name": "isoleucyl-tRNA aminoacylation", "definition": "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157419", "aliases": [], "types": ["T045"], "canonical_name": "leucyl-tRNA aminoacylation", "definition": "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157420", "aliases": [], "types": ["T045"], "canonical_name": "lysyl-tRNA aminoacylation", "definition": "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157421", "aliases": [], "types": ["T045"], "canonical_name": "methionyl-tRNA aminoacylation", "definition": "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157422", "aliases": [], "types": ["T045"], "canonical_name": "phenylalanyl-tRNA aminoacylation", "definition": "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157423", "aliases": [], "types": ["T045"], "canonical_name": "prolyl-tRNA aminoacylation", "definition": "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA. [GOC:mah, ISBN:0716730510]"}
{"concept_id": "C1157424", "aliases": [], "types": ["T045"], "canonical_name": "seryl-tRNA aminoacylation", "definition": "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157425", "aliases": [], "types": ["T045"], "canonical_name": "threonyl-tRNA aminoacylation", "definition": "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157426", "aliases": [], "types": ["T045"], "canonical_name": "tryptophanyl-tRNA aminoacylation", "definition": "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157427", "aliases": [], "types": ["T045"], "canonical_name": "tyrosyl-tRNA aminoacylation", "definition": "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157428", "aliases": [], "types": ["T045"], "canonical_name": "valyl-tRNA aminoacylation", "definition": "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. [GOC:mcc, ISBN:0716730510]"}
{"concept_id": "C1157429", "aliases": ["pretranslational amino acid modification", "charged tRNA modification", "charged tRNA amino acid modification", "pretranslation protein modification", "charged-tRNA modification", "charged-tRNA amino acid modification", "pre-translational amino acid modification"], "types": ["T045"], "definition": "The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine. [GOC:jsg]", "canonical_name": "pre-translational protein modification"}
{"concept_id": "C1157430", "aliases": [], "types": ["T045"], "canonical_name": "conversion of lysyl-tRNA to pyrrolysyl-tRNA", "definition": "The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate). [PMID:12029131, PMID:12029132, PMID:12121639]"}
{"concept_id": "C1157432", "aliases": [], "types": ["T045"], "canonical_name": "conversion of seryl-tRNAsec to selenocys-tRNAsec", "definition": "The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine. [ISBN:155581073X]"}
{"concept_id": "C1157433", "aliases": ["CD4 anabolism", "CD4 formation", "CD4 synthesis", "CD4 biosynthesis"], "types": ["T044"], "canonical_name": "CD4 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157434", "aliases": ["regulation of CD4 biosynthesis", "regulation of CD4 formation", "regulation of CD4 synthesis", "regulation of CD4 biosynthetic process", "regulation of CD4 anabolism"], "types": ["T043"], "canonical_name": "regulation of CD4 production", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. [GOC:go_curators]"}
{"concept_id": "C1157435", "aliases": ["negative regulation of CD4 formation", "down regulation of CD4 biosynthetic process", "downregulation of CD4 biosynthetic process", "negative regulation of CD4 anabolism", "negative regulation of CD4 biosynthetic process", "negative regulation of CD4 biosynthesis", "negative regulation of CD4 synthesis", "down-regulation of CD4 biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of CD4 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. [GOC:go_curators]"}
{"concept_id": "C1157436", "aliases": ["positive regulation of CD4 synthesis", "upregulation of CD4 biosynthetic process", "positive regulation of CD4 formation", "positive regulation of CD4 biosynthetic process", "positive regulation of CD4 biosynthesis", "positive regulation of CD4 anabolism", "up-regulation of CD4 biosynthetic process", "up regulation of CD4 biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of CD4 production", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. [GOC:go_curators]"}
{"concept_id": "C1157437", "aliases": ["CD95L biosynthetic process", "FasL anabolism", "fas ligand biosynthetic process", "CD95L biosynthesis", "FasL formation", "FASLG biosynthetic process", "Fas-L biosynthetic process", "APT1LG1 biosynthetic process", "FasL biosynthesis", "CD178 biosynthetic process", "FasL synthesis"], "types": ["T044"], "canonical_name": "FasL biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines. [http://www.copewithcytokines.de/]"}
{"concept_id": "C1157438", "aliases": ["regulation of FasL anabolism", "regulation of FasL formation", "regulation of FasL biosynthesis", "regulation of FasL synthesis"], "types": ["T043"], "canonical_name": "regulation of FasL production", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL. [GOC:go_curators]"}
{"concept_id": "C1157439", "aliases": ["down regulation of FasL biosynthetic process", "negative regulation of FasL biosynthesis", "negative regulation of FasL formation", "negative regulation of FasL synthesis", "downregulation of FasL biosynthetic process", "negative regulation of FasL biosynthetic process", "down-regulation of FasL biosynthetic process", "negative regulation of FasL anabolism"], "types": ["T043"], "canonical_name": "negative regulation of FasL production", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL. [GOC:go_curators]"}
{"concept_id": "C1157440", "aliases": ["positive regulation of FasL synthesis", "positive regulation of FasL anabolism", "positive regulation of FasL biosynthesis", "upregulation of FasL biosynthetic process", "up-regulation of FasL biosynthetic process", "positive regulation of FasL biosynthetic process", "positive regulation of FasL formation", "up regulation of FasL biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of FasL production", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL. [GOC:go_curators]"}
{"concept_id": "C1157446", "aliases": ["N-linked glycoprotein maturation", "glycoprotein trimming involved in glycoprotein maturation"], "types": ["T044"], "canonical_name": "N-glycan processing", "definition": "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. [ISBN:0879695595, PMID:12736198]"}
{"concept_id": "C1157447", "aliases": [], "types": ["T044"], "canonical_name": "N-glycan diversification", "definition": "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases. [ISBN:0879695595]"}
{"concept_id": "C1157448", "aliases": [], "types": ["T043"], "canonical_name": "N-glycan processing to secreted and cell-surface N-glycans", "definition": "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus. [ISBN:0879695595]"}
{"concept_id": "C1157453", "aliases": ["N-linked glycan precursor biosynthetic process", "dolichol-linked oligosaccharide synthesis", "dolichol-linked oligosaccharide formation", "oligosaccharide-PP-dolichol assembly", "dolichol-linked oligosaccharide anabolism", "dolichol-linked oligosaccharide biosynthesis", "N-linked glycan precursor biosynthesis"], "types": ["T044"], "canonical_name": "dolichol-linked oligosaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. [GOC:jl, ISBN:0471331309]"}
{"concept_id": "C1157454", "aliases": [], "types": ["T044"], "canonical_name": "oligosaccharide-lipid intermediate assembly"}
{"concept_id": "C1157457", "aliases": [], "types": ["T044"], "canonical_name": "O-glycan processing", "definition": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. [GOC:mah, GOC:pr, PMID:10580130]"}
{"concept_id": "C1157458", "aliases": [], "types": ["T044"], "canonical_name": "O-glycan processing, core 1", "definition": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc. [GOC:mah, GOC:pr, PMID:10580130]"}
{"concept_id": "C1157459", "aliases": [], "types": ["T044"], "canonical_name": "O-glycan processing, core 2", "definition": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc. [GOC:mah, GOC:pr, PMID:10580130]"}
{"concept_id": "C1157460", "aliases": [], "types": ["T044"], "canonical_name": "O-glycan processing, core 3", "definition": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-(1->3)-GalNAc. [GOC:mah, GOC:pr, PMID:10580130]"}
{"concept_id": "C1157461", "aliases": [], "types": ["T044"], "canonical_name": "O-glycan processing, core 4", "definition": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-(1->6)[GalNAc-beta-(1->3)]-GalNAc. [GOC:mah, GOC:pr, PMID:10580130]"}
{"concept_id": "C1157467", "aliases": ["protein amino acid phosphate-linked glycosylation", "phosphoglycosylation"], "types": ["T044"], "canonical_name": "protein phosphate-linked glycosylation", "definition": "The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues. [PMID:7499424]"}
{"concept_id": "C1157469", "aliases": ["O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation", "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis", "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism", "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis"], "types": ["T044"], "canonical_name": "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds. [RESID:AA0296]"}
{"concept_id": "C1157470", "aliases": ["O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation", "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis", "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis", "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism"], "types": ["T044"], "canonical_name": "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage. [RESID:AA0297]"}
{"concept_id": "C1157471", "aliases": ["protein amino acid glucuronylation"], "types": ["T044"], "canonical_name": "protein glucuronylation", "definition": "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose. [GOC:ai, GOC:pr]"}
{"concept_id": "C1157472", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid glucuronylation", "definition": "The glucuronylation of the N-terminal amino acid of proteins. [GOC:ai]"}
{"concept_id": "C1157473", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glycine N-glucuronylation", "definition": "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine. [RESID:AA0058]"}
{"concept_id": "C1157477", "aliases": ["hemoglobin anabolism", "hemoglobin biosynthesis", "hemoglobin synthesis", "haemoglobin biosynthetic process", "hemoglobin formation", "haemoglobin biosynthesis"], "types": ["T044"], "canonical_name": "hemoglobin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:jl]"}
{"concept_id": "C1157478", "aliases": ["lipoprotein synthesis", "lipoprotein biosynthesis", "lipoprotein formation", "lipoprotein anabolism"], "types": ["T044"], "canonical_name": "lipoprotein biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. [ISBN:0198506732]"}
{"concept_id": "C1157479", "aliases": ["protein amino acid lipidation", "lipid:protein modification"], "types": ["T044"], "canonical_name": "protein lipidation", "definition": "The covalent attachment of lipid groups to an amino acid in a protein. [GOC:jl]"}
{"concept_id": "C1157480", "aliases": [], "types": ["T044"], "canonical_name": "C-terminal protein lipidation", "definition": "The covalent attachment of a lipid group to the carboxy-terminus of a protein. [GOC:jl]"}
{"concept_id": "C1157481", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein lipidation", "definition": "The covalent attachment of a lipid group to the amino terminus of a protein. [GOC:jl]"}
{"concept_id": "C1157483", "aliases": ["protein amino acid myristoylation"], "types": ["T044"], "canonical_name": "protein myristoylation", "definition": "The covalent attachment of a myristoyl group to a protein. [GOC:ai]"}
{"concept_id": "C1157485", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein myristoylation", "definition": "The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein. [GOC:mah]"}
{"concept_id": "C1157486", "aliases": ["N-terminal peptidyl-glycine N-myristylation"], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glycine N-myristoylation", "definition": "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine. [RESID:AA0059]"}
{"concept_id": "C1157487", "aliases": ["peptidyl-lysine myristylation"], "types": ["T044"], "canonical_name": "peptidyl-lysine myristoylation", "definition": "The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine. [RESID:AA0078]"}
{"concept_id": "C1157488", "aliases": ["peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine", "peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine", "peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine", "peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-L-cysteine S-myristoylation", "definition": "The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine. [RESID:AA0307]"}
{"concept_id": "C1157489", "aliases": ["protein amino acid palmitoleylation"], "types": ["T044"], "canonical_name": "protein palmitoleylation", "definition": "The covalent attachment of a palmitoleyl group to a protein. [GOC:ai]"}
{"concept_id": "C1157491", "aliases": ["peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine", "peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine", "peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine", "definition": "The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically. [RESID:AA0308]"}
{"concept_id": "C1157492", "aliases": ["protein amino acid palmitoylation"], "types": ["T044"], "canonical_name": "protein palmitoylation", "definition": "The covalent attachment of a palmitoyl group to a protein. [GOC:jl, PMID:15520806]"}
{"concept_id": "C1157494", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein palmitoylation", "definition": "The covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein. [GOC:mah]"}
{"concept_id": "C1157495", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-L-cysteine N-palmitoylation", "definition": "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine. [RESID:AA0060]"}
{"concept_id": "C1157496", "aliases": ["peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine", "peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "peptidyl-cysteine S-palmitoylation", "peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-L-cysteine S-palmitoylation", "definition": "The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine. [RESID:AA0106]"}
{"concept_id": "C1157497", "aliases": ["peptidyl-serine O-palmitoylation"], "types": ["T044"], "canonical_name": "peptidyl-serine palmitoylation", "definition": "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine. [RESID:AA0080]"}
{"concept_id": "C1157498", "aliases": ["peptidyl-threonine O-palmitoylation"], "types": ["T044"], "canonical_name": "peptidyl-threonine palmitoylation", "definition": "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine. [RESID:AA0079]"}
{"concept_id": "C1157501", "aliases": ["peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine", "peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine", "peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine", "definition": "The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine. [RESID:AA0103]"}
{"concept_id": "C1157502", "aliases": ["peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine", "peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine", "peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine", "definition": "The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic. [RESID:AA0102]"}
{"concept_id": "C1157504", "aliases": ["peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine", "peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine", "peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine", "definition": "The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification. [RESID:AA0104]"}
{"concept_id": "C1157509", "aliases": ["mannoprotein biosynthesis", "mannoprotein formation", "mannoprotein anabolism", "mannoprotein synthesis"], "types": ["T044"], "canonical_name": "mannoprotein biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a mannoprotein, a protein that contains covalently bound mannose residues. [ISBN:0198506732]"}
{"concept_id": "C1157510", "aliases": ["MHC class I anabolism", "major histocompatibility complex class I biosynthetic process", "MHC class I synthesis", "MHC class I biosynthesis", "MHC class I formation", "major histocompatibility complex class I biosynthesis"], "types": ["T044"], "canonical_name": "MHC class I biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I. [GOC:go_curators]"}
{"concept_id": "C1157511", "aliases": ["regulation of MHC class I biosynthesis", "regulation of MHC class I anabolism", "regulation of major histocompatibility complex class I biosynthetic process", "regulation of major histocompatibility complex class I biosynthesis", "regulation of MHC class I formation", "regulation of MHC class I synthesis"], "types": ["T044"], "canonical_name": "regulation of MHC class I biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. [GOC:go_curators]"}
{"concept_id": "C1157512", "aliases": ["down-regulation of MHC class I biosynthetic process", "down regulation of MHC class I biosynthetic process", "downregulation of MHC class I biosynthetic process", "negative regulation of major histocompatibility complex class I biosynthetic process", "negative regulation of MHC class I biosynthesis", "negative regulation of MHC class I anabolism", "negative regulation of MHC class I synthesis", "negative regulation of MHC class I formation", "negative regulation of major histocompatibility complex class I biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of MHC class I biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. [GOC:go_curators]"}
{"concept_id": "C1157513", "aliases": ["up regulation of MHC class I biosynthetic process", "positive regulation of MHC class I synthesis", "positive regulation of major histocompatibility complex class I biosynthetic process", "up-regulation of MHC class I biosynthetic process", "positive regulation of MHC class I biosynthesis", "positive regulation of MHC class I anabolism", "upregulation of MHC class I biosynthetic process", "positive regulation of MHC class I formation", "positive regulation of major histocompatibility complex class I biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of MHC class I biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. [GOC:go_curators]"}
{"concept_id": "C1157514", "aliases": ["MHC class II biosynthesis", "MHC class II formation", "major histocompatibility complex class II biosynthetic process", "major histocompatibility complex class II biosynthesis", "MHC class II anabolism", "MHC class II synthesis"], "types": ["T044"], "canonical_name": "MHC class II biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II. [GOC:go_curators]"}
{"concept_id": "C1157515", "aliases": ["regulation of MHC class II synthesis", "regulation of MHC class II anabolism", "regulation of MHC class II formation", "regulation of MHC class II biosynthesis", "regulation of major histocompatibility complex class II biosynthetic process", "regulation of major histocompatibility complex class II biosynthesis"], "types": ["T044"], "canonical_name": "regulation of MHC class II biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. [GOC:go_curators]"}
{"concept_id": "C1157516", "aliases": ["down-regulation of MHC class II biosynthetic process", "negative regulation of MHC class II synthesis", "negative regulation of MHC class II anabolism", "negative regulation of major histocompatibility complex class II biosynthetic process", "negative regulation of MHC class II biosynthesis", "downregulation of MHC class II biosynthetic process", "negative regulation of major histocompatibility complex class II biosynthesis", "negative regulation of MHC class II formation", "down regulation of MHC class II biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of MHC class II biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. [GOC:go_curators]"}
{"concept_id": "C1157517", "aliases": ["positive regulation of MHC class II biosynthesis", "positive regulation of MHC class II formation", "positive regulation of major histocompatibility complex class II biosynthetic process", "up-regulation of MHC class II biosynthetic process", "positive regulation of MHC class II synthesis", "up regulation of MHC class II biosynthetic process", "upregulation of MHC class II biosynthetic process", "positive regulation of major histocompatibility complex class II biosynthesis", "positive regulation of MHC class II anabolism"], "types": ["T044"], "canonical_name": "positive regulation of MHC class II biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. [GOC:go_curators]"}
{"concept_id": "C1157518", "aliases": ["nonribosomal peptide biosynthesis", "non-ribosomal peptide biosynthesis", "non-ribosomal peptide formation", "nonribosomal peptide formation", "nonribosomal peptide anabolism", "nonribosomal peptide synthesis", "non-ribosomal peptide synthesis", "nonribosomal peptide biosynthetic process"], "types": ["T044"], "definition": "The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. [ISBN:0198506732]", "canonical_name": "non-ribosomal peptide biosynthetic process"}
{"concept_id": "C1157519", "aliases": ["regulation of protein anabolism", "regulation of protein biosynthesis", "regulation of protein formation", "regulation of protein synthesis"], "types": ["T043"], "canonical_name": "regulation of translation", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:isa_complete]"}
{"concept_id": "C1157520", "aliases": ["negative regulation of protein biosynthetic process", "negative regulation of protein synthesis", "down-regulation of protein biosynthetic process", "downregulation of protein biosynthetic process", "negative regulation of protein anabolism", "down regulation of protein biosynthetic process", "negative regulation of protein formation", "negative regulation of protein biosynthesis"], "types": ["T045"], "canonical_name": "negative regulation of translation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:isa_complete]"}
{"concept_id": "C1157521", "aliases": ["positive regulation of protein synthesis", "upregulation of protein biosynthetic process", "up regulation of protein biosynthetic process", "positive regulation of protein formation", "positive regulation of protein anabolism", "positive regulation of translation", "positive regulation of protein biosynthetic process", "positive regulation of protein biosynthesis"], "types": ["T045"], "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:dph, GOC:go_curators, GOC:tb]", "canonical_name": "up-regulation of protein biosynthetic process"}
{"concept_id": "C1157525", "aliases": ["down-regulation of oskar mRNA translation", "down regulation of oskar mRNA translation", "downregulation of oskar mRNA translation"], "types": ["T045"], "canonical_name": "negative regulation of oskar mRNA translation", "definition": "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein. [GOC:ems]"}
{"concept_id": "C1157526", "aliases": ["down-regulation of translational elongation", "down regulation of translational elongation", "downregulation of translational elongation"], "types": ["T045"], "canonical_name": "negative regulation of translational elongation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. [GOC:go_curators]"}
{"concept_id": "C1157527", "aliases": ["down-regulation of translational fidelity", "down regulation of translational fidelity", "downregulation of translational fidelity"], "types": ["T045"], "canonical_name": "negative regulation of translational fidelity", "definition": "Any process that decreases the ability of the translational apparatus to interpret the genetic code. [GOC:dph, GOC:tb]"}
{"concept_id": "C1157528", "aliases": ["down regulation of translational initiation", "downregulation of translational initiation", "down-regulation of translational initiation"], "types": ["T043"], "canonical_name": "negative regulation of translational initiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. [GOC:go_curators]"}
{"concept_id": "C1157529", "aliases": ["down-regulation of translational initiation by iron", "down regulation of translational initiation by iron", "downregulation of translational initiation by iron"], "types": ["T043"], "canonical_name": "negative regulation of translational initiation by iron", "definition": "Any process involving iron that stops, prevents or reduces the rate of translational initiation. [GOC:go_curators]"}
{"concept_id": "C1157530", "aliases": ["down regulation of translational termination", "down-regulation of translational termination", "downregulation of translational termination"], "types": ["T045"], "canonical_name": "negative regulation of translational termination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. [GOC:go_curators]"}
{"concept_id": "C1157533", "aliases": ["up regulation of oskar mRNA translation", "up-regulation of oskar mRNA translation", "upregulation of oskar mRNA translation"], "types": ["T045"], "canonical_name": "positive regulation of oskar mRNA translation", "definition": "Any process that activates or increases the frequency, rate or extent of oskar mRNA translation. [GOC:go_curators]"}
{"concept_id": "C1157534", "aliases": ["up-regulation of translational elongation", "up regulation of translational elongation", "upregulation of translational elongation"], "types": ["T043"], "canonical_name": "positive regulation of translational elongation", "definition": "Any process that activates or increases the frequency, rate or extent of translational elongation. [GOC:go_curators]"}
{"concept_id": "C1157535", "aliases": ["upregulation of translational fidelity", "up-regulation of translational fidelity", "up regulation of translational fidelity"], "types": ["T043"], "canonical_name": "positive regulation of translational fidelity", "definition": "Any process that increases the ability of the translational apparatus to interpret the genetic code. [GOC:dph, GOC:tb]"}
{"concept_id": "C1157536", "aliases": ["up regulation of translational initiation", "up-regulation of translational initiation", "upregulation of translational initiation"], "types": ["T045"], "canonical_name": "positive regulation of translational initiation", "definition": "Any process that activates or increases the frequency, rate or extent of translational initiation. [GOC:go_curators]"}
{"concept_id": "C1157537", "aliases": ["up-regulation of translational initiation by iron", "upregulation of translational initiation by iron", "up regulation of translational initiation by iron"], "types": ["T045"], "canonical_name": "positive regulation of translational initiation by iron", "definition": "Any process involving iron that activates or increases the rate of translational initiation. [GOC:go_curators]"}
{"concept_id": "C1157538", "aliases": ["up regulation of translational termination", "up-regulation of translational termination", "upregulation of translational termination"], "types": ["T045"], "canonical_name": "positive regulation of translational termination", "definition": "Any process that activates or increases the frequency, rate or extent of translational termination. [GOC:go_curators]"}
{"concept_id": "C1157540", "aliases": [], "types": ["T043"], "canonical_name": "regulation of oskar mRNA translation", "definition": "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex. [GOC:go_curators, PMID:12538512]"}
{"concept_id": "C1157541", "aliases": [], "types": ["T043"], "canonical_name": "regulation of translational elongation", "definition": "Any process that modulates the frequency, rate, extent or accuracy of translational elongation. [GOC:go_curators]"}
{"concept_id": "C1157542", "aliases": ["regulation of translational accuracy"], "types": ["T043"], "canonical_name": "regulation of translational fidelity", "definition": "Any process that modulates the ability of the translational apparatus to interpret the genetic code. [GOC:dph, GOC:tb]"}
{"concept_id": "C1157543", "aliases": [], "types": ["T043"], "canonical_name": "regulation of translational initiation", "definition": "Any process that modulates the frequency, rate or extent of translational initiation. [GOC:go_curators]"}
{"concept_id": "C1157544", "aliases": [], "types": ["T043"], "canonical_name": "regulation of translational initiation by iron", "definition": "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron. [GOC:jl]"}
{"concept_id": "C1157545", "aliases": [], "types": ["T043"], "canonical_name": "regulation of translational termination", "definition": "Any process that modulates the frequency, rate or extent of translational termination. [GOC:go_curators]"}
{"concept_id": "C1157546", "aliases": [], "types": ["T045"], "canonical_name": "translational attenuation", "definition": "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation. [PMID:15694341, PMID:15805513]"}
{"concept_id": "C1157548", "aliases": ["monomethylamine methyltransferase cofactor lysine adduct incorporation", "lysine methylamine methyltransferase cofactor adduct incorporation"], "types": ["T044"], "canonical_name": "pyrrolysine incorporation", "definition": "The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases. [PMID:11435424, PMID:17204561, RESID:AA0321]"}
{"concept_id": "C1157549", "aliases": [], "types": ["T045"], "canonical_name": "selenocysteine incorporation", "definition": "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine. [RESID:AA0022]"}
{"concept_id": "C1157562", "aliases": ["translation elongation"], "types": ["T045"], "canonical_name": "translational elongation", "definition": "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. [GOC:ems]"}
{"concept_id": "C1157563", "aliases": [], "types": ["T045"], "canonical_name": "protein synthesis initiation"}
{"concept_id": "C1157564", "aliases": ["translation initiation complex assembly"], "types": ["T045"], "canonical_name": "formation of translation initiation complex"}
{"concept_id": "C1157565", "aliases": ["translation initiation ternary complex assembly"], "types": ["T045"], "canonical_name": "formation of translation initiation ternary complex", "definition": "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). [GOC:hjd]"}
{"concept_id": "C1157566", "aliases": ["formation of translation pre-initiation complex", "translation preinitiation complex assembly"], "types": ["T045"], "canonical_name": "formation of translation preinitiation complex", "definition": "The joining of the small ribosomal subunit, ternary complex, and mRNA. [GOC:hjd]"}
{"concept_id": "C1157567", "aliases": ["translational complex disassembly", "translation termination"], "types": ["T045"], "canonical_name": "translational termination", "definition": "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). [GOC:hjd, ISBN:019879276X]"}
{"concept_id": "C1157569", "aliases": ["viral protein biosynthesis", "viral protein biosynthetic process", "viral protein formation", "viral protein synthesis", "viral protein anabolism"], "types": ["T043"], "canonical_name": "viral translation", "definition": "A process by which viral mRNA is translated into viral protein, using the host cellular machinery. [GOC:bf, GOC:jl, ISBN:0781702534]"}
{"concept_id": "C1157570", "aliases": ["nitric oxide synthesis", "nitric oxide anabolism", "nitric oxide biosynthesis", "nitric oxide formation"], "types": ["T044"], "canonical_name": "nitric oxide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. [GOC:ai]"}
{"concept_id": "C1157571", "aliases": ["regulation of nitric oxide synthesis", "regulation of nitric oxide anabolism", "regulation of nitric oxide formation", "regulation of nitric oxide biosynthesis"], "types": ["T043"], "canonical_name": "regulation of nitric oxide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. [GOC:go_curators]"}
{"concept_id": "C1157572", "aliases": ["negative regulation of nitric oxide anabolism", "negative regulation of nitric oxide biosynthesis", "downregulation of nitric oxide biosynthetic process", "negative regulation of nitric oxide formation", "negative regulation of nitric oxide synthesis", "down-regulation of nitric oxide biosynthetic process", "down regulation of nitric oxide biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of nitric oxide biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. [GOC:go_curators]"}
{"concept_id": "C1157573", "aliases": ["positive regulation of nitric oxide formation", "up-regulation of nitric oxide biosynthetic process", "upregulation of nitric oxide biosynthetic process", "up regulation of nitric oxide biosynthetic process", "positive regulation of nitric oxide anabolism", "positive regulation of nitric oxide biosynthesis", "positive regulation of nitric oxide synthesis"], "types": ["T043"], "canonical_name": "positive regulation of nitric oxide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. [GOC:go_curators]"}
{"concept_id": "C1157574", "aliases": ["nucleoside anabolism", "nucleoside synthesis", "nucleoside formation", "nucleoside biosynthesis"], "types": ["T044"], "canonical_name": "nucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:jl, ISBN:0140512713]"}
{"concept_id": "C1157575", "aliases": ["purine nucleoside formation", "purine nucleoside anabolism", "purine nucleoside biosynthesis", "purine nucleoside synthesis"], "types": ["T044"], "canonical_name": "purine nucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:go_curators]"}
{"concept_id": "C1157576", "aliases": ["purine ribonucleoside formation", "purine ribonucleoside synthesis", "purine ribonucleoside anabolism", "purine ribonucleoside biosynthesis"], "types": ["T044"], "canonical_name": "purine ribonucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:ai]"}
{"concept_id": "C1157577", "aliases": ["adenosine anabolism", "adenosine synthesis", "adenosine biosynthesis", "adenosine formation"], "types": ["T044"], "canonical_name": "adenosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. [GOC:go_curators]"}
{"concept_id": "C1157578", "aliases": ["bis(5'-nucleosidyl) oligophosphate biosynthesis", "bis(5'-nucleosidyl) oligophosphate formation", "bis(5'-nucleosidyl) oligophosphate synthesis", "bis(5'-nucleosidyl) oligophosphate anabolism"], "types": ["T044"], "canonical_name": "bis(5'-nucleosidyl) oligophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. [GOC:mah, PMID:10970777]"}
{"concept_id": "C1157579", "aliases": ["diadenosine polyphosphate biosynthesis", "diadenosine polyphosphate anabolism", "diadenosine polyphosphate synthesis", "diadenosine polyphosphate formation"], "types": ["T044"], "canonical_name": "diadenosine polyphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. [GOC:ai]"}
{"concept_id": "C1157580", "aliases": ["diadenosine tetraphosphate formation", "diadenosine tetraphosphate anabolism", "diadenosine tetraphosphate biosynthesis", "diadenosine tetraphosphate synthesis"], "types": ["T044"], "canonical_name": "diadenosine tetraphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. [GOC:ai]"}
{"concept_id": "C1157581", "aliases": ["diadenosine triphosphate synthesis", "diadenosine triphosphate formation", "diadenosine triphosphate biosynthesis", "diadenosine triphosphate anabolism"], "types": ["T044"], "canonical_name": "diadenosine triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. [GOC:ai]"}
{"concept_id": "C1157582", "aliases": ["guanosine synthesis", "guanosine anabolism", "guanosine biosynthesis", "guanosine formation"], "types": ["T044"], "canonical_name": "guanosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution. [GOC:go_curators]"}
{"concept_id": "C1157583", "aliases": ["7-methylguanosine formation", "7-methylguanosine biosynthesis", "7-methylguanosine anabolism", "7-methylguanosine synthesis"], "types": ["T044"], "canonical_name": "7-methylguanosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA. [ISBN:0198506732]"}
{"concept_id": "C1157584", "aliases": ["queuosine anabolism", "queuosine formation", "queuosine biosynthesis", "queuosine synthesis"], "types": ["T044"], "canonical_name": "queuosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157585", "aliases": ["guanosine pentaphosphate synthesis", "guanosine pentaphosphate anabolism", "guanosine pentaphosphate (5'-pppGpp-3') biosynthesis", "guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process", "guanosine pentaphosphate biosynthesis", "guanosine pentaphosphate formation"], "types": ["T044"], "canonical_name": "guanosine pentaphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. [GOC:ai]"}
{"concept_id": "C1157586", "aliases": ["guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process", "guanosine tetraphosphate synthesis", "guanosine tetraphosphate (5'-ppGpp-3') biosynthesis", "guanosine tetraphosphate anabolism", "guanosine tetraphosphate formation", "guanosine tetraphosphate biosynthesis"], "types": ["T044"], "canonical_name": "guanosine tetraphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. [GOC:ai]"}
{"concept_id": "C1157587", "aliases": ["pyrimidine nucleoside anabolism", "pyrimidine nucleoside formation", "pyrimidine nucleoside biosynthesis", "pyrimidine nucleoside synthesis"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1157588", "aliases": ["pyrimidine ribonucleoside formation", "pyrimidine ribonucleoside synthesis", "pyrimidine ribonucleoside biosynthesis", "pyrimidine ribonucleoside anabolism"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:ai]"}
{"concept_id": "C1157589", "aliases": ["cytidine formation", "cytidine biosynthesis", "cytidine anabolism", "cytidine synthesis"], "types": ["T044"], "canonical_name": "cytidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside. [GOC:go_curators]"}
{"concept_id": "C1157590", "aliases": ["inosine formation", "inosine biosynthesis", "inosine synthesis", "inosine anabolism"], "types": ["T044"], "canonical_name": "inosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. [GOC:go_curators]"}
{"concept_id": "C1157591", "aliases": ["uridine biosynthesis", "uridine formation", "uridine synthesis", "uridine anabolism"], "types": ["T044"], "canonical_name": "uridine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. [GOC:go_curators]"}
{"concept_id": "C1157592", "aliases": ["nucleotide biosynthesis", "nucleotide synthesis", "nucleotide formation", "nucleotide biosynthetic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). [GOC:go_curators]", "canonical_name": "nucleotide anabolism"}
{"concept_id": "C1157593", "aliases": ["cyclic nucleotide anabolism", "cyclic nucleotide formation", "cyclic nucleotide synthesis", "cyclic nucleotide biosynthesis"], "types": ["T044"], "canonical_name": "cyclic nucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157594", "aliases": ["3',5'-cAMP biosynthetic process", "cyclic AMP biosynthetic process", "3',5' cAMP biosynthetic process", "cAMP synthesis", "adenosine 3',5'-cyclophosphate biosynthesis", "cAMP formation", "cAMP anabolism", "adenosine 3',5'-cyclophosphate biosynthetic process", "3',5'-cAMP biosynthesis", "cAMP biosynthesis", "3',5' cAMP biosynthesis", "cyclic AMP biosynthesis"], "types": ["T044"], "canonical_name": "cAMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). [ISBN:0198506732]"}
{"concept_id": "C1157595", "aliases": ["cGMP synthesis", "cGMP anabolism", "cGMP biosynthesis", "cGMP formation"], "types": ["T044"], "canonical_name": "cGMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. [ISBN:0198506732]"}
{"concept_id": "C1157596", "aliases": ["deoxyribonucleotide anabolism", "deoxyribonucleotide biosynthesis", "deoxyribonucleotide synthesis", "deoxyribonucleotide formation"], "types": ["T044"], "canonical_name": "deoxyribonucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157597", "aliases": ["2'-deoxyribonucleotide anabolism", "2'-deoxyribonucleotide biosynthesis", "2'-deoxyribonucleotide synthesis", "2'-deoxyribonucleotide formation"], "types": ["T044"], "canonical_name": "2'-deoxyribonucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:mah]"}
{"concept_id": "C1157598", "aliases": ["deoxyribonucleoside diphosphate anabolism", "deoxyribonucleoside diphosphate formation", "deoxyribonucleoside diphosphate biosynthesis", "deoxyribonucleoside diphosphate synthesis"], "types": ["T044"], "canonical_name": "deoxyribonucleoside diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157599", "aliases": ["purine deoxyribonucleoside diphosphate synthesis", "purine deoxyribonucleoside diphosphate biosynthesis", "purine deoxyribonucleoside diphosphate anabolism", "purine deoxyribonucleoside diphosphate formation"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157600", "aliases": ["dADP formation", "dADP biosynthesis", "dADP anabolism", "dADP synthesis"], "types": ["T044"], "canonical_name": "dADP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). [ISBN:0198506732]"}
{"concept_id": "C1157601", "aliases": ["dGDP synthesis", "dGDP anabolism", "dGDP formation", "dGDP biosynthesis"], "types": ["T044"], "canonical_name": "dGDP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). [ISBN:0198506732]"}
{"concept_id": "C1157602", "aliases": ["pyrimidine deoxyribonucleoside diphosphate formation", "pyrimidine deoxyribonucleoside diphosphate biosynthesis", "pyrimidine deoxyribonucleoside diphosphate synthesis", "pyrimidine deoxyribonucleoside diphosphate anabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157603", "aliases": ["dCDP biosynthesis", "dCDP synthesis", "dCDP formation", "dCDP anabolism"], "types": ["T044"], "canonical_name": "dCDP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157604", "aliases": ["dTDP synthesis", "dTDP anabolism", "dTDP formation", "dTDP biosynthesis"], "types": ["T044"], "canonical_name": "dTDP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate). [ISBN:0198506732]"}
{"concept_id": "C1157605", "aliases": ["dUDP biosynthesis", "dUDP synthesis", "dUDP formation", "dUDP anabolism"], "types": ["T044"], "canonical_name": "dUDP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate). [ISBN:0198506732]"}
{"concept_id": "C1157606", "aliases": ["deoxyribonucleoside monophosphate formation", "deoxyribonucleoside monophosphate biosynthesis", "deoxyribonucleoside monophosphate synthesis", "deoxyribonucleoside monophosphate anabolism"], "types": ["T044"], "canonical_name": "deoxyribonucleoside monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157607", "aliases": ["purine deoxyribonucleoside monophosphate biosynthesis", "purine deoxyribonucleoside monophosphate anabolism", "purine deoxyribonucleoside monophosphate formation", "purine deoxyribonucleoside monophosphate synthesis"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157608", "aliases": ["dAMP anabolism", "dAMP biosynthesis", "dAMP formation", "dAMP synthesis"], "types": ["T044"], "canonical_name": "dAMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). [ISBN:0198506732]"}
{"concept_id": "C1157609", "aliases": ["dGMP biosynthesis", "dGMP anabolism", "dGMP synthesis", "dGMP formation"], "types": ["T044"], "canonical_name": "dGMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). [ISBN:0198506732]"}
{"concept_id": "C1157610", "aliases": ["pyrimidine deoxyribonucleoside monophosphate synthesis", "pyrimidine deoxyribonucleoside monophosphate biosynthesis", "pyrimidine deoxyribonucleoside monophosphate anabolism", "pyrimidine deoxyribonucleoside monophosphate formation"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157611", "aliases": ["dCMP anabolism", "dCMP formation", "dCMP synthesis", "dCMP biosynthesis"], "types": ["T044"], "canonical_name": "dCMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1157612", "aliases": ["deoxycytidine monophosphate salvage"], "types": ["T044"], "canonical_name": "dCMP salvage", "definition": "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157613", "aliases": ["dTMP biosynthesis", "dTMP anabolism", "dTMP formation", "dTMP synthesis"], "types": ["T044"], "canonical_name": "dTMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). [ISBN:0198506732]"}
{"concept_id": "C1157614", "aliases": ["dUMP formation", "dUMP synthesis", "dUMP anabolism", "dUMP biosynthesis"], "types": ["T044"], "canonical_name": "dUMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate). [ISBN:0198506732]"}
{"concept_id": "C1157615", "aliases": ["deoxyribonucleoside triphosphate synthesis", "deoxyribonucleoside triphosphate biosynthesis", "deoxyribonucleoside triphosphate formation", "deoxyribonucleoside triphosphate anabolism"], "types": ["T044"], "canonical_name": "deoxyribonucleoside triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157616", "aliases": ["purine deoxyribonucleoside triphosphate anabolism", "purine deoxyribonucleoside triphosphate formation", "purine deoxyribonucleoside triphosphate synthesis", "purine deoxyribonucleoside triphosphate biosynthesis"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157617", "aliases": [], "types": ["T044"], "canonical_name": "dADP phosphorylation", "definition": "The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP. [ISBN:0198506732]"}
{"concept_id": "C1157618", "aliases": ["dATP synthesis", "dATP biosynthesis", "dATP anabolism", "dATP formation"], "types": ["T044"], "canonical_name": "dATP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). [ISBN:0198506732]"}
{"concept_id": "C1157619", "aliases": ["dATP formation from ADP", "dATP synthesis from ADP", "dATP anabolism from ADP"], "types": ["T044"], "canonical_name": "dATP biosynthetic process from ADP", "definition": "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157620", "aliases": [], "types": ["T044"], "canonical_name": "dGDP phosphorylation", "definition": "The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP. [ISBN:0198506732]"}
{"concept_id": "C1157621", "aliases": ["dGTP formation", "dGTP synthesis", "dGTP biosynthesis", "dGTP anabolism"], "types": ["T044"], "canonical_name": "dGTP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1157622", "aliases": ["dGTP anabolism from dGDP", "dGTP synthesis from dGDP", "dGTP formation from dGDP"], "types": ["T044"], "canonical_name": "dGTP biosynthetic process from dGDP", "definition": "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157623", "aliases": [], "types": ["T044"], "canonical_name": "dIDP phosphorylation", "definition": "The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP. [ISBN:0198506732]"}
{"concept_id": "C1157624", "aliases": ["pyrimidine deoxyribonucleoside triphosphate synthesis", "pyrimidine deoxyribonucleoside triphosphate biosynthesis", "pyrimidine deoxyribonucleoside triphosphate anabolism", "pyrimidine deoxyribonucleoside triphosphate formation"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157625", "aliases": ["dCTP formation", "dCTP synthesis", "dCTP biosynthesis", "dCTP anabolism"], "types": ["T044"], "canonical_name": "dCTP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157626", "aliases": ["dTTP anabolism", "dTTP formation", "dTTP biosynthesis", "dTTP synthesis"], "types": ["T044"], "canonical_name": "dTTP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157627", "aliases": ["dUTP biosynthesis", "dUTP synthesis", "dUTP anabolism", "dUTP formation"], "types": ["T044"], "canonical_name": "dUTP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157628", "aliases": ["purine deoxyribonucleotide formation", "purine deoxyribonucleotide synthesis", "purine deoxyribonucleotide anabolism", "purine deoxyribonucleotide biosynthesis"], "types": ["T044"], "canonical_name": "purine deoxyribonucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157629", "aliases": ["pyrimidine deoxyribonucleotide formation", "pyrimidine deoxyribonucleotide synthesis", "pyrimidine deoxyribonucleotide anabolism", "pyrimidine deoxyribonucleotide biosynthesis"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157630", "aliases": ["nucleoside diphosphate anabolism", "nucleoside diphosphate synthesis", "nucleoside diphosphate formation", "nucleoside diphosphate biosynthesis"], "types": ["T044"], "canonical_name": "nucleoside diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157631", "aliases": ["purine nucleoside diphosphate anabolism", "purine nucleoside diphosphate biosynthesis", "purine nucleoside diphosphate synthesis", "purine nucleoside diphosphate formation"], "types": ["T044"], "canonical_name": "purine nucleoside diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157632", "aliases": ["purine ribonucleoside diphosphate formation", "purine ribonucleoside diphosphate anabolism", "purine ribonucleoside diphosphate synthesis", "purine ribonucleoside diphosphate biosynthesis"], "types": ["T044"], "canonical_name": "purine ribonucleoside diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157633", "aliases": ["ADP synthesis", "ADP anabolism", "ADP biosynthesis", "ADP formation"], "types": ["T044"], "canonical_name": "ADP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate. [GOC:ai]"}
{"concept_id": "C1157634", "aliases": ["GDP anabolism", "GDP synthesis", "GDP biosynthesis", "GDP formation"], "types": ["T044"], "canonical_name": "GDP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate. [GOC:ai]"}
{"concept_id": "C1157635", "aliases": ["IDP biosynthetic process", "IDP anabolism", "IDP biosynthesis", "IDP formation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate. [GOC:ai]", "canonical_name": "IDP synthesis"}
{"concept_id": "C1157636", "aliases": ["pyrimidine nucleoside diphosphate biosynthesis", "pyrimidine nucleoside diphosphate synthesis", "pyrimidine nucleoside diphosphate formation", "pyrimidine nucleoside diphosphate anabolism"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157637", "aliases": ["pyrimidine ribonucleoside diphosphate biosynthesis", "pyrimidine ribonucleoside diphosphate anabolism", "pyrimidine ribonucleoside diphosphate synthesis", "pyrimidine ribonucleoside diphosphate formation"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157638", "aliases": ["CDP anabolism", "CDP biosynthesis", "CDP synthesis", "CDP formation"], "types": ["T044"], "canonical_name": "CDP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate. [GOC:ai]"}
{"concept_id": "C1157639", "aliases": ["TDP synthesis", "TDP biosynthesis", "TDP anabolism", "TDP formation"], "types": ["T044"], "canonical_name": "TDP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157640", "aliases": ["UDP synthesis", "UDP biosynthesis", "UDP formation", "UDP anabolism"], "types": ["T044"], "canonical_name": "UDP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157641", "aliases": ["ribonucleoside diphosphate formation", "ribonucleoside diphosphate anabolism", "ribonucleoside diphosphate synthesis", "ribonucleoside diphosphate biosynthesis"], "types": ["T044"], "canonical_name": "ribonucleoside diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157642", "aliases": ["nucleoside monophosphate formation", "nucleoside monophosphate synthesis", "nucleoside monophosphate biosynthesis", "nucleoside monophosphate anabolism"], "types": ["T044"], "canonical_name": "nucleoside monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157643", "aliases": ["purine nucleoside monophosphate anabolism", "purine nucleoside monophosphate biosynthesis", "purine nucleoside monophosphate formation", "purine nucleoside monophosphate synthesis"], "types": ["T044"], "canonical_name": "purine nucleoside monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157644", "aliases": ["purine ribonucleoside monophosphate biosynthesis", "purine ribonucleoside monophosphate formation", "purine ribonucleoside monophosphate synthesis", "purine ribonucleoside monophosphate anabolism"], "types": ["T044"], "canonical_name": "purine ribonucleoside monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157645", "aliases": ["AMP anabolism", "AMP formation", "AMP synthesis", "AMP biosynthesis"], "types": ["T044"], "canonical_name": "AMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157646", "aliases": ["adenine salvage pathway"], "types": ["T044"], "canonical_name": "adenine salvage", "definition": "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157647", "aliases": [], "types": ["T044"], "canonical_name": "adenosine salvage", "definition": "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157648", "aliases": ["GMP formation", "GMP anabolism", "GMP synthesis", "GMP biosynthesis"], "types": ["T044"], "canonical_name": "GMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1157649", "aliases": [], "types": ["T044"], "canonical_name": "deoxyguanosine salvage", "definition": "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157650", "aliases": [], "types": ["T044"], "canonical_name": "guanine salvage", "definition": "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157651", "aliases": [], "types": ["T044"], "canonical_name": "guanosine salvage", "definition": "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157652", "aliases": ["IMP anabolism", "IMP formation", "IMP biosynthesis", "IMP synthesis"], "types": ["T044"], "canonical_name": "IMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1157653", "aliases": ["'de novo' IMP formation", "'de novo' IMP anabolism", "'de novo' IMP biosynthesis", "'de novo' IMP synthesis"], "types": ["T044"], "canonical_name": "'de novo' IMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. [GOC:mah, ISBN:0716720094]"}
{"concept_id": "C1157654", "aliases": [], "types": ["T044"], "canonical_name": "deoxyinosine salvage", "definition": "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157655", "aliases": [], "types": ["T044"], "canonical_name": "inosine salvage", "definition": "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157656", "aliases": ["pyrimidine nucleoside monophosphate biosynthesis", "pyrimidine nucleoside monophosphate anabolism", "pyrimidine nucleoside monophosphate formation", "pyrimidine nucleoside monophosphate synthesis"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157657", "aliases": ["pyrimidine ribonucleoside monophosphate formation", "pyrimidine ribonucleoside monophosphate anabolism", "pyrimidine ribonucleoside monophosphate biosynthesis", "pyrimidine ribonucleoside monophosphate synthesis"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157658", "aliases": ["CMP anabolism", "CMP formation", "CMP synthesis", "CMP biosynthesis"], "types": ["T044"], "canonical_name": "CMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1157659", "aliases": ["cytidine monophosphate salvage"], "types": ["T044"], "canonical_name": "CMP salvage", "definition": "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157660", "aliases": ["TMP formation", "TMP biosynthesis", "TMP synthesis", "TMP anabolism"], "types": ["T044"], "canonical_name": "TMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1157661", "aliases": ["UMP biosynthesis", "UMP anabolism", "UMP synthesis", "UMP formation"], "types": ["T044"], "canonical_name": "UMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1157662", "aliases": [], "types": ["T044"], "canonical_name": "uracil salvage", "definition": "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157664", "aliases": ["ribonucleoside monophosphate formation", "ribonucleoside monophosphate biosynthesis", "ribonucleoside monophosphate synthesis", "ribonucleoside monophosphate anabolism"], "types": ["T044"], "canonical_name": "ribonucleoside monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157665", "aliases": ["nucleoside triphosphate anabolism", "nucleoside triphosphate formation", "nucleoside triphosphate synthesis", "nucleoside triphosphate biosynthesis"], "types": ["T044"], "canonical_name": "nucleoside triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157666", "aliases": ["purine nucleoside triphosphate anabolism", "purine nucleoside triphosphate biosynthesis", "purine nucleoside triphosphate formation", "purine nucleoside triphosphate synthesis"], "types": ["T044"], "canonical_name": "purine nucleoside triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157667", "aliases": ["purine ribonucleoside triphosphate formation", "purine ribonucleoside triphosphate anabolism", "purine ribonucleoside triphosphate synthesis", "purine ribonucleoside triphosphate biosynthesis"], "types": ["T044"], "canonical_name": "purine ribonucleoside triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157668", "aliases": ["GTP synthesis", "GTP formation", "GTP biosynthesis", "GTP anabolism"], "types": ["T044"], "canonical_name": "GTP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157669", "aliases": [], "types": ["T044"], "canonical_name": "IDP phosphorylation", "definition": "The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP. [GOC:ai]"}
{"concept_id": "C1157670", "aliases": ["ITP biosynthesis", "ITP formation", "ITP synthesis", "ITP anabolism"], "types": ["T044"], "canonical_name": "ITP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1157671", "aliases": ["pyrimidine nucleoside triphosphate biosynthesis", "pyrimidine nucleoside triphosphate anabolism", "pyrimidine nucleoside triphosphate formation", "pyrimidine nucleoside triphosphate synthesis"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157672", "aliases": ["ribonucleoside triphosphate formation", "ribonucleoside triphosphate biosynthesis", "ribonucleoside triphosphate synthesis", "ribonucleoside triphosphate anabolism"], "types": ["T044"], "canonical_name": "ribonucleoside triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157673", "aliases": ["pyrimidine ribonucleoside triphosphate formation", "pyrimidine ribonucleoside triphosphate biosynthesis", "pyrimidine ribonucleoside triphosphate anabolism", "pyrimidine ribonucleoside triphosphate synthesis"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157674", "aliases": ["CTP anabolism", "CTP synthesis", "CTP biosynthesis", "CTP formation"], "types": ["T044"], "canonical_name": "CTP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157675", "aliases": ["TTP biosynthesis", "TTP synthesis", "TTP formation", "TTP anabolism"], "types": ["T044"], "canonical_name": "TTP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157676", "aliases": ["UTP formation", "UTP anabolism", "UTP synthesis", "UTP biosynthesis"], "types": ["T044"], "canonical_name": "UTP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157677", "aliases": ["purine nucleotide formation", "purine nucleotide anabolism", "purine nucleotide synthesis", "purine nucleotide biosynthesis"], "types": ["T044"], "canonical_name": "purine nucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157678", "aliases": ["purine ribonucleotide anabolism", "purine ribonucleotide formation", "purine ribonucleotide synthesis", "purine ribonucleotide biosynthesis"], "types": ["T044"], "canonical_name": "purine ribonucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157679", "aliases": ["pyrimidine nucleotide anabolism", "pyrimidine nucleotide synthesis", "pyrimidine nucleotide biosynthesis", "pyrimidine nucleotide formation"], "types": ["T044"], "canonical_name": "pyrimidine nucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157680", "aliases": ["pyrimidine ribonucleotide biosynthesis", "pyrimidine ribonucleotide synthesis", "pyrimidine ribonucleotide formation", "pyrimidine ribonucleotide anabolism"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157681", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine salvage"}
{"concept_id": "C1157682", "aliases": [], "types": ["T044"], "canonical_name": "cytidine salvage", "definition": "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157683", "aliases": [], "types": ["T044"], "canonical_name": "deoxycytidine salvage", "definition": "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1157684", "aliases": ["ribonucleotide biosynthesis", "ribonucleotide synthesis", "ribonucleotide formation", "ribonucleotide anabolism"], "types": ["T044"], "canonical_name": "ribonucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157685", "aliases": ["nucleotide-sugar anabolism", "nucleotide-sugar formation", "nucleotide-sugar synthesis", "nucleotide-sugar biosynthesis"], "types": ["T044"], "canonical_name": "nucleotide-sugar biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [ISBN:0198506732]"}
{"concept_id": "C1157687", "aliases": ["cyanate formation", "cyanate anabolism", "cyanate biosynthesis", "cyanate synthesis"], "types": ["T044"], "canonical_name": "cyanate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid. [GOC:ai]"}
{"concept_id": "C1157688", "aliases": ["cyanide biosynthesis", "cyanide synthesis", "cyanide anabolism", "cyanide formation"], "types": ["T044"], "canonical_name": "cyanide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. [GOC:ai]"}
{"concept_id": "C1157689", "aliases": ["formic acid biosynthetic process", "formic acid biosynthesis", "formate synthesis", "formate anabolism", "formate formation", "formate biosynthesis"], "types": ["T044"], "canonical_name": "formate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. [ISBN:0198506732]"}
{"concept_id": "C1157690", "aliases": ["methane biosynthesis", "methane biosynthetic process"], "types": ["T044"], "canonical_name": "methanogenesis", "definition": "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. [GOC:ai]"}
{"concept_id": "C1157691", "aliases": ["methane biosynthetic process from acetate", "methane biosynthesis from acetate"], "types": ["T044"], "canonical_name": "methanogenesis, from acetate", "definition": "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate. [GOC:ai]"}
{"concept_id": "C1157692", "aliases": ["methane biosynthetic process from carbon dioxide", "methane biosynthesis from carbon dioxide"], "types": ["T044"], "canonical_name": "methanogenesis, from carbon dioxide", "definition": "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2). [GOC:ai]"}
{"concept_id": "C1157693", "aliases": ["methane biosynthetic process from methanol", "methane biosynthesis from methanol"], "types": ["T044"], "canonical_name": "methanogenesis, from methanol", "definition": "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol. [GOC:ai]"}
{"concept_id": "C1157694", "aliases": ["organic acid synthesis", "organic acid biosynthesis", "organic acid formation", "organic acid anabolism"], "types": ["T044"], "canonical_name": "organic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. [ISBN:0198506732]"}
{"concept_id": "C1157695", "aliases": ["carboxylic acid synthesis", "carboxylic acid formation", "carboxylic acid anabolism", "carboxylic acid biosynthesis"], "types": ["T044"], "canonical_name": "carboxylic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. [ISBN:0198506732]"}
{"concept_id": "C1157696", "aliases": ["acetate biosynthesis", "acetate anabolism", "acetate synthesis", "acetate formation"], "types": ["T044"], "canonical_name": "acetate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. [GOC:go_curators]"}
{"concept_id": "C1157697", "aliases": ["acetate formation from carbon monoxide", "carbon monoxide dehydrogenase pathway", "acetate anabolism from carbon monoxide", "acetate synthesis from carbon monoxide"], "types": ["T044"], "canonical_name": "acetate biosynthetic process from carbon monoxide", "definition": "The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide. [GOC:go_curators]"}
{"concept_id": "C1157699", "aliases": ["polyketide biosynthesis", "polyketide anabolism", "polyketide synthesis", "polyketide formation"], "types": ["T044"], "canonical_name": "polyketide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157700", "aliases": ["acetyl-CoA anabolism", "acetyl-CoA biosynthesis", "acetyl-CoA formation", "acetyl-CoA synthesis"], "types": ["T044"], "canonical_name": "acetyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. [GOC:go_curators]"}
{"concept_id": "C1157701", "aliases": ["pyruvate dehydrogenase pathway", "acetyl-CoA formation from pyruvate", "acetyl-CoA anabolism from pyruvate", "acetyl-CoA synthesis from pyruvate"], "types": ["T044"], "canonical_name": "acetyl-CoA biosynthetic process from pyruvate", "definition": "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1157702", "aliases": ["Ljungdahl-Wood pathway", "reductive acetyl CoA pathway"], "types": ["T044"], "canonical_name": "carbon fixation by acetyl-CoA pathway", "definition": "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2). [PMID:11607093]"}
{"concept_id": "C1157703", "aliases": ["aldaric acid synthesis", "aldaric acid anabolism", "aldaric acid biosynthesis", "aldaric acid formation"], "types": ["T044"], "canonical_name": "aldaric acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. [ISBN:0198506732]"}
{"concept_id": "C1157704", "aliases": ["galactarate formation", "galactarate anabolism", "galactarate biosynthesis", "galactarate synthesis"], "types": ["T044"], "canonical_name": "galactarate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid. [GOC:pr, ISBN:0198506732]"}
{"concept_id": "C1157705", "aliases": ["glucarate anabolism", "glucarate formation", "glucarate synthesis", "glucarate biosynthesis"], "types": ["T044"], "canonical_name": "glucarate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid. [ISBN:0198506732]"}
{"concept_id": "C1157706", "aliases": ["butanoic acid formation", "butanoic acid biosynthesis", "butanoic acid synthesis", "butyrate biosynthesis", "butyrate anabolism", "butanoic acid biosynthetic process", "butanoic acid anabolism", "butyrate formation", "butyrate synthesis"], "types": ["T044"], "canonical_name": "butyrate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid. [ISBN:0198506732]"}
{"concept_id": "C1157707", "aliases": ["2-oxobutyrate formation", "alpha-ketobutyrate biosynthetic process", "2-oxobutyrate synthesis", "2-oxobutyrate anabolism", "2-oxobutyrate biosynthesis", "alpha-ketobutyrate biosynthesis"], "types": ["T044"], "canonical_name": "2-oxobutyrate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. [ISBN:0198506732]"}
{"concept_id": "C1157708", "aliases": ["glucuronate anabolism", "glucuronate synthesis", "glucuronate formation", "glucuronate biosynthesis"], "types": ["T044"], "canonical_name": "glucuronate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid. [GOC:ai]"}
{"concept_id": "C1157709", "aliases": ["UDP-glucuronate biosynthesis", "UDP-glucuronate synthesis", "UDP-glucuronate formation", "UDP-glucuronate anabolism"], "types": ["T044"], "canonical_name": "UDP-glucuronate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1157710", "aliases": ["lactate anabolism", "lactate synthesis", "lactate biosynthesis", "lactate formation"], "types": ["T044"], "canonical_name": "lactate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid. [GOC:go_curators]"}
{"concept_id": "C1157711", "aliases": ["lactate formation from pyruvate", "lactate synthesis from pyruvate", "lactate anabolism from pyruvate", "pyruvate fermentation to lactate"], "types": ["T044"], "canonical_name": "lactate biosynthetic process from pyruvate", "definition": "The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate. [GOC:go_curators]"}
{"concept_id": "C1157712", "aliases": ["D(-)-lactate synthesis from pyruvate", "D(-)-lactate formation from pyruvate", "D(-)-lactate anabolism from pyruvate"], "types": ["T044"], "canonical_name": "D(-)-lactate biosynthetic process from pyruvate", "definition": "The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate. [GOC:go_curators]"}
{"concept_id": "C1157713", "aliases": ["L(+)-lactate synthesis from pyruvate", "L(+)-lactate anabolism from pyruvate", "S-lactate biosynthetic process from pyruvate", "L(+)-lactate formation from pyruvate"], "types": ["T044"], "canonical_name": "L(+)-lactate biosynthetic process from pyruvate", "definition": "The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate. [GOC:go_curators]"}
{"concept_id": "C1157714", "aliases": ["propionate anabolism", "propionate formation", "propionate synthesis", "propionate biosynthesis"], "types": ["T044"], "canonical_name": "propionate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid. [GOC:go_curators]"}
{"concept_id": "C1157715", "aliases": ["organomercury anabolism", "organomercury formation", "organomercury biosynthesis", "organomercury synthesis"], "types": ["T044"], "canonical_name": "organomercury biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom. [GOC:ai]"}
{"concept_id": "C1157716", "aliases": ["methylmercury formation", "methylmercury biosynthesis", "methylmercury anabolism", "methylmercury synthesis"], "types": ["T044"], "canonical_name": "methylmercury biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal. [GOC:ai]"}
{"concept_id": "C1157717", "aliases": ["pigment synthesis", "pigment formation", "pigment biosynthesis", "pigment anabolism"], "types": ["T044"], "canonical_name": "pigment biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. [ISBN:0198506732]"}
{"concept_id": "C1157718", "aliases": ["eye pigment synthesis", "eye pigment anabolism", "eye pigment formation", "eye pigment biosynthesis"], "types": ["T044"], "canonical_name": "eye pigment biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. [GOC:ai]"}
{"concept_id": "C1157719", "aliases": ["rhodopsin synthesis", "rhodopsin biosynthesis", "rhodopsin anabolism", "rhodopsin formation"], "types": ["T044"], "canonical_name": "rhodopsin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. [ISBN:0198506732]"}
{"concept_id": "C1157720", "aliases": ["melanin biosynthesis", "melanin anabolism", "melanin synthesis", "melanin formation"], "types": ["T044"], "canonical_name": "melanin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. [GOC:curators]"}
{"concept_id": "C1157721", "aliases": ["ocellus pigment biosynthesis", "ocellus pigment formation", "ocellus pigment synthesis", "ocellus pigment anabolism"], "types": ["T044"], "canonical_name": "ocellus pigment biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ocellus pigments, general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. [GOC:ai, PMID:15176085, PMID:18421706]"}
{"concept_id": "C1157722", "aliases": ["polyphosphate biosynthesis", "polyphosphate anabolism", "polyphosphate synthesis", "polyphosphate formation"], "types": ["T044"], "canonical_name": "polyphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. [ISBN:0198506732]"}
{"concept_id": "C1157723", "aliases": ["regulation of formation", "regulation of synthesis", "regulation of biosynthesis", "regulation of anabolism"], "types": ["T043"], "canonical_name": "regulation of biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. [GOC:go_curators]"}
{"concept_id": "C1157724", "aliases": ["downregulation of biosynthetic process", "negative regulation of synthesis", "down-regulation of biosynthetic process", "negative regulation of biosynthesis", "negative regulation of anabolism", "negative regulation of formation", "down regulation of biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of biosynthetic process", "definition": "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. [GOC:go_curators]"}
{"concept_id": "C1157725", "aliases": ["positive regulation of synthesis", "positive regulation of biosynthesis", "positive regulation of anabolism", "up-regulation of biosynthetic process", "up regulation of biosynthetic process", "positive regulation of formation", "upregulation of biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. [GOC:go_curators]"}
{"concept_id": "C1157726", "aliases": ["ribonucleoside anabolism", "ribonucleoside synthesis", "ribonucleoside biosynthesis", "ribonucleoside formation"], "types": ["T044"], "canonical_name": "ribonucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:jl]"}
{"concept_id": "C1157727", "aliases": ["terpene biosynthesis", "terpene synthesis", "terpene formation", "terpene anabolism"], "types": ["T044"], "canonical_name": "terpene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units. [GOC:ai]"}
{"concept_id": "C1157728", "aliases": ["alpha-pinene formation", "alpha-pinene biosynthesis", "alpha-pinene synthesis", "alpha-pinene anabolism"], "types": ["T044"], "canonical_name": "alpha-pinene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. [GOC:ai]"}
{"concept_id": "C1157729", "aliases": ["limonene anabolism", "limonene biosynthesis", "limonene formation", "limonene synthesis"], "types": ["T044"], "canonical_name": "limonene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. [GOC:ai]"}
{"concept_id": "C1157730", "aliases": ["fat-soluble vitamin formation", "fat-soluble vitamin anabolism", "fat-soluble vitamin synthesis", "fat-soluble vitamin biosynthesis"], "types": ["T044"], "canonical_name": "fat-soluble vitamin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157731", "aliases": ["calciferol biosynthesis", "vitamin D synthesis", "vitamin D formation", "vitamin D biosynthesis", "vitamin D anabolism", "calciferol biosynthetic process"], "types": ["T044"], "canonical_name": "vitamin D biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]"}
{"concept_id": "C1157732", "aliases": ["water-soluble vitamin biosynthesis", "water-soluble vitamin anabolism", "water-soluble vitamin synthesis", "water-soluble vitamin formation"], "types": ["T044"], "canonical_name": "water-soluble vitamin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water. [GOC:jl]"}
{"concept_id": "C1157733", "aliases": ["vitamin H biosynthesis", "vitamin H biosynthetic process", "biotin biosynthesis", "biotin anabolism", "biotin synthesis", "vitamin B7 biosynthetic process", "vitamin B7 biosynthesis", "biotin formation"], "types": ["T044"], "canonical_name": "biotin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. [ISBN:0198506732]"}
{"concept_id": "C1157734", "aliases": ["vitamin C biosynthetic process", "L-ascorbic acid synthesis", "L-ascorbic acid formation", "ascorbate biosynthesis", "vitamin C biosynthesis", "L-ascorbic acid anabolism", "L-ascorbic acid biosynthesis", "ascorbate biosynthetic process"], "types": ["T044"], "canonical_name": "L-ascorbic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. [GOC:ma, ISBN:0198547684]"}
{"concept_id": "C1157735", "aliases": ["thiamin anabolism", "thiamine synthesis", "thiamine formation", "vitamin B1 biosynthetic process", "thiamine biosynthesis", "vitamin B1 biosynthesis", "thiamin biosynthetic process"], "types": ["T044"], "canonical_name": "thiamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157736", "aliases": ["vitamin B2 biosynthesis", "riboflavin synthesis", "riboflavin formation", "vitamin G biosynthetic process", "riboflavin anabolism", "riboflavin biosynthesis", "vitamin G biosynthesis", "vitamin B2 biosynthetic process"], "types": ["T044"], "canonical_name": "riboflavin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]"}
{"concept_id": "C1157737", "aliases": ["aldonic acid metabolism"], "types": ["T044"], "canonical_name": "aldonic acid metabolic process", "definition": "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. [ISBN:0198506732]"}
{"concept_id": "C1157738", "aliases": ["aldonic acid catabolism", "aldonic acid degradation", "aldonic acid breakdown"], "types": ["T044"], "canonical_name": "aldonic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. [ISBN:0198506732]"}
{"concept_id": "C1157740", "aliases": ["D-gluconate breakdown", "D-gluconate degradation", "D-gluconate catabolism"], "types": ["T044"], "canonical_name": "D-gluconate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. [ISBN:0198506732]"}
{"concept_id": "C1157741", "aliases": ["ketogluconate catabolism", "ketogluconate breakdown", "ketogluconate degradation"], "types": ["T044"], "canonical_name": "ketogluconate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group. [ISBN:0198506732]"}
{"concept_id": "C1157742", "aliases": ["L-idonate degradation", "L-idonate breakdown", "L-idonate catabolism"], "types": ["T044"], "canonical_name": "L-idonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. [GOC:curators]"}
{"concept_id": "C1157744", "aliases": ["D-gluconate metabolism"], "types": ["T044"], "canonical_name": "D-gluconate metabolic process", "definition": "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. [ISBN:0198506732]"}
{"concept_id": "C1157745", "aliases": ["ketogluconate metabolism"], "types": ["T044"], "canonical_name": "ketogluconate metabolic process", "definition": "The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group. [ISBN:0198506732]"}
{"concept_id": "C1157746", "aliases": ["L-idonate metabolism"], "types": ["T044"], "canonical_name": "L-idonate metabolic process", "definition": "The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. [GOC:ai]"}
{"concept_id": "C1157747", "aliases": ["carbohydrate breakdown", "carbohydrate catabolism", "catabolic carbohydrate metabolism", "catabolic carbohydrate metabolic process", "carbohydrate degradation"], "types": ["T044"], "canonical_name": "carbohydrate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [ISBN:0198506732]"}
{"concept_id": "C1157748", "aliases": ["disaccharide degradation", "disaccharide catabolism", "disaccharide breakdown"], "types": ["T044"], "canonical_name": "disaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units. [GOC:ai]"}
{"concept_id": "C1157749", "aliases": ["lactose catabolism", "lactose degradation", "lactose breakdown"], "types": ["T044"], "canonical_name": "lactose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose. [GOC:go_curators]"}
{"concept_id": "C1157750", "aliases": ["lactose degradation via tagatose-6-phosphate", "lactose breakdown via tagatose-6-phosphate"], "types": ["T044"], "canonical_name": "lactose catabolic process via tagatose-6-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate. [GOC:go_curators]"}
{"concept_id": "C1157751", "aliases": ["lactose degradation via UDP-galactose", "lactose breakdown via UDP-galactose"], "types": ["T044"], "canonical_name": "lactose catabolic process via UDP-galactose", "definition": "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose. [GOC:go_curators]"}
{"concept_id": "C1157752", "aliases": ["lactose breakdown, using glucoside 3-dehydrogenase", "lactose degradation, using glucoside 3-dehydrogenase"], "types": ["T044"], "canonical_name": "lactose catabolic process, using glucoside 3-dehydrogenase", "definition": "The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase. [GOC:jl]"}
{"concept_id": "C1157754", "aliases": ["malt sugar catabolism", "maltose breakdown", "maltose degradation", "malt sugar catabolic process"], "types": ["T040"], "canonical_name": "maltose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157755", "aliases": ["melibiose catabolism", "melibiose breakdown", "melibiose degradation"], "types": ["T044"], "canonical_name": "melibiose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. [ISBN:0198547684]"}
{"concept_id": "C1157756", "aliases": ["sucrose breakdown", "sucrose degradation", "sucrose catabolism"], "types": ["T044"], "canonical_name": "sucrose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside. [GOC:go_curators]"}
{"concept_id": "C1157759", "aliases": ["trehalose degradation", "mycose catabolism", "mykose catabolism", "trehalose catabolism", "mykose catabolic process", "mycose catabolic process", "trehalose breakdown"], "types": ["T044"], "canonical_name": "trehalose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. [GOC:jl, ISBN:0028623819]"}
{"concept_id": "C1157760", "aliases": ["glucuronoside catabolism", "glucuronide catabolism", "glucuronoside breakdown", "glucuronoside degradation", "glucuronide catabolic process"], "types": ["T044"], "canonical_name": "glucuronoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue. [ISBN:0198506732]"}
{"concept_id": "C1157761", "aliases": ["O-glycoside degradation", "O-glycoside breakdown", "O-glycoside catabolism", "glycoside breakdown", "O-glycoside catabolic process", "glycoside degradation", "glycoside catabolism"], "types": ["T044"], "canonical_name": "glycoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. [GOC:go_curators]"}
{"concept_id": "C1157762", "aliases": ["cyanogenic glycoside breakdown", "cyanogenic glycoside degradation", "cyanogenic glycoside catabolism"], "types": ["T044"], "canonical_name": "cyanogenic glycoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. [ISBN:0198506732]"}
{"concept_id": "C1157763", "aliases": ["glycosinolate catabolism", "glycosinolate degradation", "glycosinolate breakdown"], "types": ["T044"], "canonical_name": "glycosinolate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]"}
{"concept_id": "C1157764", "aliases": ["glucosinolate degradation", "glucosinolate catabolism", "glucosinolate breakdown"], "types": ["T044"], "canonical_name": "glucosinolate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. [GOC:ai]"}
{"concept_id": "C1157766", "aliases": ["S-glycoside catabolism", "S-glycoside degradation", "thioglycoside catabolic process", "S-glycoside breakdown", "thioglycoside catabolism"], "types": ["T044"], "canonical_name": "S-glycoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group. [ISBN:0198506732]"}
{"concept_id": "C1157767", "aliases": ["saponin catabolism", "saponin breakdown", "saponin degradation"], "types": ["T044"], "canonical_name": "saponin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection. [GOC:go_curators]"}
{"concept_id": "C1157768", "aliases": ["oligosaccharide breakdown", "oligosaccharide catabolism", "oligosaccharide degradation"], "types": ["T044"], "canonical_name": "oligosaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]"}
{"concept_id": "C1157769", "aliases": ["murein catabolism", "murein catabolic process", "peptidoglycan breakdown", "peptidoglycan degradation", "peptidoglycan catabolism"], "types": ["T044"], "canonical_name": "peptidoglycan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]"}
{"concept_id": "C1157770", "aliases": ["polysaccharide breakdown", "polysaccharide degradation", "polysaccharide catabolism"], "types": ["T044"], "canonical_name": "polysaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [PMID:33139480]"}
{"concept_id": "C1157771", "aliases": ["alginate catabolism", "alginic acid breakdown", "alginate catabolic process", "alginic acid degradation", "alginic acid catabolism"], "types": ["T044"], "canonical_name": "alginic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). [ISBN:0198506732]"}
{"concept_id": "C1157772", "aliases": ["beta-1,4-linked N-acetylglucosamine catabolism", "chitin catabolism", "chitin degradation", "chitin breakdown", "beta-1,4-linked N-acetylglucosamine catabolic process"], "types": ["T044"], "canonical_name": "chitin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157773", "aliases": ["cell wall chitin breakdown", "cell wall chitin catabolism", "cell wall chitin degradation"], "types": ["T044"], "canonical_name": "cell wall chitin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. [GOC:ai]"}
{"concept_id": "C1157774", "aliases": ["cuticle chitin breakdown", "cuticle chitin catabolism", "cuticle chitin degradation"], "types": ["T044"], "canonical_name": "cuticle chitin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. [GOC:ai]"}
{"concept_id": "C1157775", "aliases": ["glucan catabolism", "glucan degradation", "glucan breakdown"], "types": ["T044"], "canonical_name": "glucan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. [GOC:go_curators]"}
{"concept_id": "C1157776", "aliases": ["1,3-beta-glucan catabolism", "beta-1,3 glucan degradation", "1,3-beta-glucan breakdown", "beta-1,3 glucan breakdown", "beta-1,3 glucan catabolism", "beta-1,3 glucan catabolic process", "1,3-beta-D-glucan catabolic process", "1,3-beta-glucan degradation"], "types": ["T044"], "canonical_name": "(1->3)-beta-D-glucan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (1->3)-beta-D-glucans. [GOC:ai]"}
{"concept_id": "C1157777", "aliases": ["1,6-beta-D-glucan catabolism", "beta-1,6 glucan catabolic process", "1,6-beta-D-glucan breakdown", "beta-1,6 glucan catabolism", "1,6-beta-D-glucan catabolic process", "beta-1,6 glucan degradation", "1,6-beta-D-glucan degradation", "beta-1,6 glucan breakdown"], "types": ["T044"], "canonical_name": "(1->6)-beta-D-glucan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (1->6)-beta-D-glucans. [GOC:ai]"}
{"concept_id": "C1157778", "aliases": ["cellulose catabolism", "cellulose breakdown", "cellulose degradation"], "types": ["T044"], "canonical_name": "cellulose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157780", "aliases": ["regulation of glycogenolysis", "regulation of glycogen degradation", "regulation of glycogen breakdown", "regulation of glycogen catabolism"], "types": ["T044"], "canonical_name": "regulation of glycogen catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. [GOC:go_curators]"}
{"concept_id": "C1157781", "aliases": ["negative regulation of glycogen catabolism", "negative regulation of glycogenolysis", "negative regulation of glycogen degradation", "down regulation of glycogen catabolic process", "down-regulation of glycogen catabolic process", "downregulation of glycogen catabolic process", "negative regulation of glycogen breakdown"], "types": ["T043"], "canonical_name": "negative regulation of glycogen catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. [GOC:go_curators]"}
{"concept_id": "C1157782", "aliases": ["up regulation of glycogen catabolic process", "upregulation of glycogen catabolic process", "positive regulation of glycogen catabolism", "up-regulation of glycogen catabolic process", "positive regulation of glycogenolysis", "positive regulation of glycogen breakdown", "positive regulation of glycogen degradation"], "types": ["T043"], "canonical_name": "positive regulation of glycogen catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. [GOC:go_curators]"}
{"concept_id": "C1157783", "aliases": ["starch breakdown", "starch degradation", "starch catabolism"], "types": ["T044"], "canonical_name": "starch catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants. [GOC:ai]"}
{"concept_id": "C1157784", "aliases": ["lipopolysaccharide catabolism", "lipopolysaccharide degradation", "LPS catabolic process", "lipopolysaccharide breakdown"], "types": ["T044"], "canonical_name": "lipopolysaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. [GOC:ai]"}
{"concept_id": "C1157785", "aliases": ["mannan breakdown", "mannan catabolism", "mannan degradation"], "types": ["T044"], "canonical_name": "mannan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. [ISBN:0198506732]"}
{"concept_id": "C1157786", "aliases": ["pectin degradation", "pectin breakdown", "pectin catabolism"], "types": ["T044"], "canonical_name": "pectin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. [GOC:go_curators, PMID:11931668]"}
{"concept_id": "C1157787", "aliases": ["xylan breakdown", "xylan degradation", "xylan catabolism"], "types": ["T044"], "canonical_name": "xylan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone. [GOC:go_curators, PMID:11931668]"}
{"concept_id": "C1157788", "aliases": ["proteoglycan degradation", "proteoglycan catabolism", "proteoglycan breakdown"], "types": ["T044"], "canonical_name": "proteoglycan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157789", "aliases": ["heparan sulphate proteoglycan catabolism", "heparan sulfate proteoglycan degradation", "heparan sulfate proteoglycan catabolism", "heparan sulfate proteoglycan breakdown", "heparan sulphate proteoglycan catabolic process"], "types": ["T044"], "canonical_name": "heparan sulfate proteoglycan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157790", "aliases": ["disaccharide metabolism"], "types": ["T044"], "canonical_name": "disaccharide metabolic process", "definition": "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units. [GOC:jl, ISBN:0192800981]"}
{"concept_id": "C1157791", "aliases": ["lactose metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose. [GOC:go_curators]", "canonical_name": "lactose metabolic process"}
{"concept_id": "C1157792", "aliases": ["malt sugar metabolic process", "malt sugar metabolism", "maltose metabolism"], "types": ["T044"], "canonical_name": "maltose metabolic process", "definition": "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157793", "aliases": ["melibiose metabolism"], "types": ["T044"], "canonical_name": "melibiose metabolic process", "definition": "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. [ISBN:0198547684]"}
{"concept_id": "C1157794", "aliases": ["sucrose metabolism"], "types": ["T044"], "canonical_name": "sucrose metabolic process", "definition": "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. [GOC:go_curators]"}
{"concept_id": "C1157795", "aliases": ["mycose metabolic process", "mykose metabolic process", "mykose metabolism", "trehalose metabolism", "mycose metabolism"], "types": ["T044"], "canonical_name": "trehalose metabolic process", "definition": "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. [GOC:jl, ISBN:0028623819]"}
{"concept_id": "C1157796", "aliases": ["glucuronide metabolic process", "glucuronoside metabolism", "glucuronide metabolism"], "types": ["T044"], "canonical_name": "glucuronoside metabolic process", "definition": "The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate. [ISBN:0198506732]"}
{"concept_id": "C1157797", "aliases": ["glycoside metabolism", "O-glycoside metabolic process", "O-glycoside metabolism"], "types": ["T044"], "canonical_name": "glycoside metabolic process", "definition": "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. [ISBN:0198547684]"}
{"concept_id": "C1157798", "aliases": ["cyanogenic glycoside metabolism"], "types": ["T044"], "canonical_name": "cyanogenic glycoside metabolic process", "definition": "The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. [ISBN:0198506732]"}
{"concept_id": "C1157799", "aliases": ["glycosinolate metabolism"], "types": ["T044"], "canonical_name": "glycosinolate metabolic process", "definition": "The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]"}
{"concept_id": "C1157800", "aliases": ["glucosinolate metabolism"], "types": ["T044"], "canonical_name": "glucosinolate metabolic process", "definition": "The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans. [GOC:curators]"}
{"concept_id": "C1157802", "aliases": ["thioglycoside metabolism", "S-glycoside metabolism", "thioglycoside metabolic process"], "types": ["T044"], "canonical_name": "S-glycoside metabolic process", "definition": "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group. [ISBN:0198506732]"}
{"concept_id": "C1157803", "aliases": ["saponin metabolism"], "types": ["T044"], "canonical_name": "saponin metabolic process", "definition": "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection. [ISBN:0198547684]"}
{"concept_id": "C1157805", "aliases": [], "types": ["T044"], "canonical_name": "Entner-Doudoroff pathway through 6-phosphogluconate", "definition": "A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. [GOC:jl, MetaCyc:ENTNER-DOUDOROFF-PWY-I, PMID:12921356, PMID:12981024]"}
{"concept_id": "C1157807", "aliases": ["alpha-ketoglutarate metabolic process", "alpha-ketoglutarate metabolism", "alpha-oxoglutarate metabolism", "2-ketoglutarate metabolic process", "2-ketoglutarate metabolism", "2-oxoglutarate metabolism", "alpha-oxoglutarate metabolic process"], "types": ["T044"], "canonical_name": "2-oxoglutarate metabolic process", "definition": "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. [ISBN:0198506732]"}
{"concept_id": "C1157808", "aliases": ["citrate metabolism"], "types": ["T044"], "canonical_name": "citrate metabolic process", "definition": "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle. [ISBN:0198506732]"}
{"concept_id": "C1157809", "aliases": ["fumarate metabolism"], "types": ["T044"], "canonical_name": "fumarate metabolic process", "definition": "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. [ISBN:0198506732]"}
{"concept_id": "C1157810", "aliases": ["isocitrate metabolism"], "types": ["T044"], "canonical_name": "isocitrate metabolic process", "definition": "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. [ISBN:0198506732]"}
{"concept_id": "C1157811", "aliases": ["malate metabolism"], "types": ["T044"], "canonical_name": "malate metabolic process", "definition": "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. [ISBN:0198506732]"}
{"concept_id": "C1157812", "aliases": ["oxaloacetate metabolism"], "types": ["T044"], "canonical_name": "oxaloacetate metabolic process", "definition": "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. [ISBN:0198506732]"}
{"concept_id": "C1157813", "aliases": ["succinate metabolism"], "types": ["T044"], "canonical_name": "succinate metabolic process", "definition": "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle. [ISBN:0198506732]"}
{"concept_id": "C1157814", "aliases": ["succinate-propionate fermentation"], "types": ["T044"], "canonical_name": "glycolytic fermentation to propionate", "definition": "Glycolytic fermentation resulting in the catabolism of glucose to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate. [GOC:dph, GOC:nr, MetaCyc:P108-PWY]"}
{"concept_id": "C1157815", "aliases": ["succinyl-CoA metabolism"], "types": ["T044"], "canonical_name": "succinyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A. [GOC:ai]"}
{"concept_id": "C1157816", "aliases": ["L-methylmalonyl-CoA synthesis", "L-methylmalonyl-CoA anabolism", "L-methylmalonyl-CoA formation", "L-methylmalonyl-CoA biosynthesis"], "types": ["T044"], "canonical_name": "L-methylmalonyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1157818", "aliases": ["reductive carboxylic acid cycle", "reductive Kreb's cycle", "reductive carboxylate cycle", "reductive TCA cycle", "reductive citric acid pathway"], "types": ["T044"], "canonical_name": "reductive tricarboxylic acid cycle", "definition": "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate. [GOC:jl, PMID:15838028]"}
{"concept_id": "C1157819", "aliases": ["oligosaccharide metabolism"], "types": ["T044"], "canonical_name": "oligosaccharide metabolic process", "definition": "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]"}
{"concept_id": "C1157820", "aliases": ["lipopolysaccharide core region metabolism", "LPS core region metabolic process"], "types": ["T044"], "canonical_name": "lipopolysaccharide core region metabolic process", "definition": "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains. [ISBN:0198506732]"}
{"concept_id": "C1157821", "aliases": ["peptidoglycan metabolism", "murein metabolism", "murein metabolic process"], "types": ["T044"], "canonical_name": "peptidoglycan metabolic process", "definition": "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network. [ISBN:0198506732, PMID:33139480]"}
{"concept_id": "C1157822", "aliases": ["murein turnover"], "types": ["T044"], "canonical_name": "peptidoglycan turnover", "definition": "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall. [GOC:jl]"}
{"concept_id": "C1157823", "aliases": ["glycan metabolism", "polysaccharide metabolism", "glycan metabolic process"], "types": ["T040"], "canonical_name": "polysaccharide metabolic process", "definition": "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [ISBN:0198547684]"}
{"concept_id": "C1157824", "aliases": ["alginic acid metabolism", "alginate metabolism", "alginate metabolic process"], "types": ["T044"], "canonical_name": "alginic acid metabolic process", "definition": "The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). [ISBN:0198506732]"}
{"concept_id": "C1157825", "aliases": ["beta-1,4-linked N-acetylglucosamine metabolic process", "chitin metabolism", "beta-1,4-linked N-acetylglucosamine metabolism"], "types": ["T044"], "canonical_name": "chitin metabolic process", "definition": "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157826", "aliases": ["cell wall chitin metabolism"], "types": ["T044"], "canonical_name": "cell wall chitin metabolic process", "definition": "The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. [GOC:ai]"}
{"concept_id": "C1157827", "aliases": ["chitin localisation", "establishment and maintenance of chitin localization"], "types": ["T042"], "canonical_name": "chitin localization", "definition": "A process in which chitin is transported to, or maintained in, a specific location. [GOC:ai]"}
{"concept_id": "C1157828", "aliases": ["cuticle chitin metabolism"], "types": ["T044"], "canonical_name": "cuticle chitin metabolic process", "definition": "The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. [GOC:ai]"}
{"concept_id": "C1157829", "aliases": ["colanic acid metabolism"], "types": ["T044"], "canonical_name": "colanic acid metabolic process", "definition": "The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues. [GOC:ai, http://www.science.siu.edu/microbiology/micr425/425Notes/02-CellEnv.html]"}
{"concept_id": "C1157830", "aliases": ["enterobacterial common antigen metabolism"], "types": ["T044"], "canonical_name": "enterobacterial common antigen metabolic process", "definition": "The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. [GOC:ma]"}
{"concept_id": "C1157831", "aliases": ["extracellular polysaccharide metabolism"], "types": ["T044"], "canonical_name": "extracellular polysaccharide metabolic process", "definition": "The chemical reactions and pathways involving polysaccharides used in extracellular structures. [GOC:ai]"}
{"concept_id": "C1157832", "aliases": ["GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolism"], "types": ["T044"], "canonical_name": "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process", "definition": "The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1157833", "aliases": ["cellular glucan metabolism"], "types": ["T043"], "canonical_name": "cellular glucan metabolic process", "definition": "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell. [ISBN:0198547684]"}
{"concept_id": "C1157835", "aliases": ["1,6-beta-glucan metabolism", "beta-1,6 glucan metabolism", "beta-1,6 glucan metabolic process", "1,6-beta-glucan metabolic process"], "types": ["T044"], "canonical_name": "(1->6)-beta-D-glucan metabolic process", "definition": "The chemical reactions and pathways involving (1->6)-beta-D-glucans, compounds composed of glucose residues linked by (1->6)-beta-D-glucosidic bonds. [ISBN:0198506732]"}
{"concept_id": "C1157836", "aliases": ["cellulose metabolism"], "types": ["T044"], "canonical_name": "cellulose metabolic process", "definition": "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157837", "aliases": ["starch metabolism"], "types": ["T044"], "canonical_name": "starch metabolic process", "definition": "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose. [ISBN:0198506732]"}
{"concept_id": "C1157838", "aliases": ["K antigen metabolism"], "types": ["T044"], "canonical_name": "K antigen metabolic process", "definition": "The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens. [ISBN:0198506732]"}
{"concept_id": "C1157839", "aliases": ["lipopolysaccharide metabolism", "LPS metabolic process"], "types": ["T044"], "canonical_name": "lipopolysaccharide metabolic process", "definition": "The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. [ISBN:0198506732]"}
{"concept_id": "C1157840", "aliases": ["mannan metabolism"], "types": ["T044"], "canonical_name": "mannan metabolic process", "definition": "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units. [GOC:tair_curators]"}
{"concept_id": "C1157841", "aliases": ["O antigen metabolism"], "types": ["T044"], "canonical_name": "O antigen metabolic process", "definition": "The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide. [ISBN:0198506732]"}
{"concept_id": "C1157842", "aliases": ["pectin metabolism"], "types": ["T044"], "canonical_name": "pectin metabolic process", "definition": "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge. [GOC:tair_curators]"}
{"concept_id": "C1157843", "aliases": ["xylan metabolism"], "types": ["T044"], "canonical_name": "xylan metabolic process", "definition": "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone. [GOC:go_curators, PMID:11931668]"}
{"concept_id": "C1157844", "aliases": ["proteoglycan metabolism"], "types": ["T044"], "canonical_name": "proteoglycan metabolic process", "definition": "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157845", "aliases": ["heparan sulfate proteoglycan metabolism", "heparan sulphate proteoglycan metabolism", "heparan sulphate proteoglycan metabolic process"], "types": ["T044"], "canonical_name": "heparan sulfate proteoglycan metabolic process", "definition": "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157846", "aliases": ["proteoglycan sulfate transfer"], "types": ["T044"], "canonical_name": "proteoglycan sulfate transfer", "definition": "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate. [GOC:hjd]"}
{"concept_id": "C1157847", "aliases": ["regulation of carbohydrate metabolism"], "types": ["T043"], "canonical_name": "regulation of carbohydrate metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. [GOC:go_curators]"}
{"concept_id": "C1157848", "aliases": ["negative regulation of carbohydrate metabolism", "down-regulation of carbohydrate metabolic process", "downregulation of carbohydrate metabolic process", "down regulation of carbohydrate metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of carbohydrate metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. [GOC:go_curators]"}
{"concept_id": "C1157849", "aliases": ["up regulation of carbohydrate metabolic process", "up-regulation of carbohydrate metabolic process", "positive regulation of carbohydrate metabolism", "upregulation of carbohydrate metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of carbohydrate metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. [GOC:go_curators]"}
{"concept_id": "C1157850", "aliases": ["carbon utilization by utilization of organic compounds", "carbon utilization"], "types": ["T044"], "definition": "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. [GOC:mah, GOC:mlg]", "canonical_name": "heterotrophy"}
{"concept_id": "C1157851", "aliases": [], "types": ["T044"], "canonical_name": "lithotrophy"}
{"concept_id": "C1157852", "aliases": ["alkaloid catabolism", "alkaloid breakdown", "alkaloid degradation"], "types": ["T044"], "canonical_name": "alkaloid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). [GOC:lr, ISBN:0122146743]"}
{"concept_id": "C1157853", "aliases": ["nicotine breakdown", "nicotine catabolism", "nicotine degradation"], "types": ["T044"], "canonical_name": "nicotine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. [GOC:sm, ISBN:0198547684]"}
{"concept_id": "C1157854", "aliases": ["alkanesulphonate catabolic process", "alkanesulphonate catabolism", "alkanesulfonate catabolism", "alkanesulfonate degradation", "alkanesulfonate breakdown"], "types": ["T044"], "canonical_name": "alkanesulfonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. [GOC:ai]"}
{"concept_id": "C1157855", "aliases": ["cellular cell wall macromolecule degradation", "cell wall degradation", "cellular cell wall macromolecule catabolic process", "cellular cell wall macromolecule breakdown", "cell wall catabolism", "cell wall breakdown", "cellular cell wall macromolecule catabolism"], "types": ["T043"], "canonical_name": "cell wall macromolecule catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. [GOC:go_curators]"}
{"concept_id": "C1157856", "aliases": ["coenzyme and prosthetic group catabolic process"], "types": ["T044"], "canonical_name": "coenzyme and prosthetic group catabolism", "definition": "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes and prosthetic groups. [GOC:ai]"}
{"concept_id": "C1157858", "aliases": ["coenzyme A degradation", "coenzyme A breakdown", "CoA catabolism", "coenzyme A catabolism"], "types": ["T044"], "canonical_name": "coenzyme A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [ISBN:0198547684]"}
{"concept_id": "C1157859", "aliases": ["glutathione catabolism", "glutathione degradation", "glutathione breakdown"], "types": ["T044"], "canonical_name": "glutathione catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1157860", "aliases": ["pantothenate catabolism", "vitamin B5 catabolic process", "vitamin B5 catabolism", "pantothenate degradation", "pantothenate breakdown"], "types": ["T044"], "canonical_name": "pantothenate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. [GOC:ai, ISBN:0721662544]"}
{"concept_id": "C1157861", "aliases": ["pyridine nucleotide breakdown", "pyridine nucleotide catabolism", "pyridine nucleotide degradation"], "types": ["T044"], "canonical_name": "pyridine nucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. [GOC:jl, GOC:pde, GOC:vw]"}
{"concept_id": "C1157863", "aliases": ["NADP (reduced) catabolism", "oxidized nicotinamide adenine dinucleotide phosphate catabolic process", "NADP (reduced) catabolic process", "reduced NADP catabolism", "oxidized nicotinamide adenine dinucleotide phosphate catabolism", "NADP (oxidized) catabolism", "reduced nicotinamide adenine dinucleotide phosphate catabolism", "NADP degradation", "reduced NADP catabolic process", "NADPH catabolism", "NADP catabolism", "nicotinamide adenine dinucleotide phosphate catabolism", "NADP breakdown", "NADPH catabolic process", "reduced nicotinamide adenine dinucleotide phosphate catabolic process", "oxidized NADP catabolic process", "oxidized NADP catabolism", "NADP (oxidized) catabolic process", "nicotinamide adenine dinucleotide phosphate catabolic process"], "types": ["T044"], "canonical_name": "NADP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. [GOC:mah]"}
{"concept_id": "C1157864", "aliases": ["nicotinamide adenine dinucleotide catabolism", "nicotinamide adenine dinucleotide catabolic process", "NAD (oxidized) catabolism", "reduced nicotinamide adenine dinucleotide catabolic process", "oxidized NAD catabolic process", "NADH catabolic process", "reduced nicotinamide adenine dinucleotide catabolism", "NADH catabolism", "NAD breakdown", "NAD (reduced) catabolic process", "reduced NAD catabolism", "reduced NAD catabolic process", "oxidized nicotinamide adenine dinucleotide catabolic process", "oxidized NAD catabolism", "oxidized nicotinamide adenine dinucleotide catabolism", "NAD degradation", "NAD catabolism", "NAD (oxidized) catabolic process", "NAD (reduced) catabolism"], "types": ["T044"], "canonical_name": "NAD catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH. [GOC:jl, ISBN:0618254153]"}
{"concept_id": "C1157865", "aliases": ["nicotinamide riboside breakdown", "nicotinamide riboside catabolism", "N-ribosylnicotinamide catabolic process", "nicotinamide riboside degradation"], "types": ["T044"], "canonical_name": "nicotinamide riboside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. [ISBN:0198506732]"}
{"concept_id": "C1157866", "aliases": ["quinone cofactor catabolic process", "quinone cofactor degradation", "quinone cofactor breakdown"], "types": ["T044"], "canonical_name": "quinone cofactor catabolism"}
{"concept_id": "C1157867", "aliases": ["vitamin K breakdown", "vitamin K degradation", "naphthoquinone catabolic process", "naphthoquinone catabolism", "vitamin K catabolism"], "types": ["T044"], "canonical_name": "vitamin K catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]"}
{"concept_id": "C1157868", "aliases": ["phytonadione catabolic process", "phytonadione catabolism", "phytomenadione catabolic process", "phylloquinone catabolism", "vitamin K1 catabolism", "phylloquinone breakdown", "phytylmenaquinone catabolic process", "phytylmenaquinone catabolism", "vitamin K1 catabolic process", "phytomenadione catabolism", "phylloquinone degradation"], "types": ["T044"], "canonical_name": "phylloquinone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]"}
{"concept_id": "C1157869", "aliases": ["menaquinone breakdown", "menaquinone catabolism", "vitamin K2 catabolism", "menaquinone degradation", "menatetrenone catabolic process", "multiprenylmenaquinone catabolism", "multiprenylmenaquinone catabolic process", "vitamin K2 catabolic process", "menatetrenone catabolism"], "types": ["T044"], "canonical_name": "menaquinone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]"}
{"concept_id": "C1157870", "aliases": ["thiamin diphosphate catabolism", "thiamine pyrophosphate catabolism", "thiamin diphosphate degradation", "thiamin pyrophosphate catabolic process", "TPP catabolic process", "thiamine diphosphate catabolism", "thiamin pyrophosphate catabolism", "thiamin diphosphate breakdown", "thiamin diphosphate catabolic process", "thiamine pyrophosphate catabolic process", "TPP catabolism"], "types": ["T044"], "canonical_name": "thiamine diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1157871", "aliases": ["corrin catabolism", "corrin breakdown", "corrin degradation"], "types": ["T044"], "canonical_name": "corrin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule. [GOC:ai]"}
{"concept_id": "C1157872", "aliases": ["porphyrin breakdown", "porphyrin degradation", "porphyrin catabolic process"], "types": ["T044"], "canonical_name": "porphyrin catabolism"}
{"concept_id": "C1157873", "aliases": [], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin. [DOI:10.1016/0305-0491(80)90243-6]", "canonical_name": "bilirubin conjugation"}
{"concept_id": "C1157874", "aliases": ["chlorophyll catabolism", "chlorophyll breakdown", "chlorophyll degradation"], "types": ["T044"], "canonical_name": "chlorophyll catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products. [GOC:jl]"}
{"concept_id": "C1157875", "aliases": ["bacteriochlorophyll breakdown", "bacteriochlorophyll degradation", "bacteriochlorophyll catabolism"], "types": ["T044"], "canonical_name": "bacteriochlorophyll catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. [GOC:go_curators]"}
{"concept_id": "C1157876", "aliases": ["heme breakdown", "heme catabolism", "haem catabolic process", "heme degradation", "haem catabolism"], "types": ["T044"], "canonical_name": "heme catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:jl]"}
{"concept_id": "C1157877", "aliases": ["heme a degradation", "heme a catabolism", "haem a catabolism", "haem a catabolic process", "heme a breakdown"], "types": ["T044"], "canonical_name": "heme a catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3. [GOC:curators, PMID:28352909]"}
{"concept_id": "C1157878", "aliases": ["heme C breakdown", "haem C catabolic process", "haem C catabolism", "heme C degradation", "heme C catabolism"], "types": ["T044"], "canonical_name": "heme C catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of heme C, a derivative of heme found in cytochromes c, b4, and f. [GOC:curators]"}
{"concept_id": "C1157879", "aliases": ["siroheme degradation", "siroheme catabolism", "sirohaem catabolic process", "sirohaem catabolism", "siroheme breakdown"], "types": ["T044"], "canonical_name": "siroheme catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. [ISBN:0198506732]"}
{"concept_id": "C1157880", "aliases": ["haem oxidation"], "types": ["T044"], "canonical_name": "heme oxidation", "definition": "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme. [GOC:mah]"}
{"concept_id": "C1157881", "aliases": ["vitamin B12 catabolism", "vitamin B12 catabolic process", "cobalamin breakdown", "cobalamin degradation", "cobalamin catabolism"], "types": ["T044"], "canonical_name": "cobalamin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. [GOC:go_curators]"}
{"concept_id": "C1157882", "aliases": [], "types": ["T044"], "canonical_name": "siderochrome catabolism"}
{"concept_id": "C1157883", "aliases": ["deoxyribonucleoside catabolism", "deoxyribonucleoside degradation", "deoxyribonucleoside breakdown"], "types": ["T044"], "canonical_name": "deoxyribonucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1157884", "aliases": ["purine deoxyribonucleoside catabolism", "purine deoxyribonucleoside breakdown", "purine deoxyribonucleoside degradation"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1157885", "aliases": ["deoxyadenosine catabolism", "deoxyadenosine degradation", "deoxyadenosine breakdown"], "types": ["T044"], "canonical_name": "deoxyadenosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA. [GOC:go_curators]"}
{"concept_id": "C1157887", "aliases": [], "types": ["T044"], "canonical_name": "deoxyadenosine phosphorolysis"}
{"concept_id": "C1157888", "aliases": ["deoxyguanosine catabolism", "deoxyguanosine degradation", "deoxyguanosine breakdown"], "types": ["T044"], "canonical_name": "deoxyguanosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. [GOC:jl]"}
{"concept_id": "C1157889", "aliases": ["pyrimidine deoxyribonucleoside breakdown", "pyrimidine deoxyribonucleoside catabolism", "pyrimidine deoxyribonucleoside degradation"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1157890", "aliases": ["deoxycytidine degradation", "deoxycytidine breakdown", "deoxycytidine catabolism"], "types": ["T044"], "canonical_name": "deoxycytidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. [GOC:go_curators]"}
{"concept_id": "C1157891", "aliases": ["deoxyinosine catabolism", "deoxyinosine breakdown", "deoxyinosine degradation"], "types": ["T044"], "canonical_name": "deoxyinosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside. [GOC:go_curators]"}
{"concept_id": "C1157892", "aliases": ["deoxyuridine catabolism", "deoxyuridine breakdown", "deoxyuridine degradation"], "types": ["T044"], "canonical_name": "deoxyuridine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA. [GOC:go_curators]"}
{"concept_id": "C1157893", "aliases": ["deoxyribosylthymine catabolism", "thymidine catabolism", "thymidine degradation", "deoxyribosylthymine catabolic process", "thymidine breakdown"], "types": ["T044"], "canonical_name": "thymidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. [GOC:go_curators]"}
{"concept_id": "C1157894", "aliases": ["DNA catabolism", "DNA breakdown", "DNA degradation"], "types": ["T045"], "canonical_name": "DNA catabolic process", "definition": "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157895", "aliases": ["endonucleolytic DNA catabolism", "DNA breakdown, endonucleolytic", "DNA degradation, endonucleolytic", "endonucleolytic degradation of DNA"], "types": ["T045"], "canonical_name": "DNA catabolic process, endonucleolytic", "definition": "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. [GOC:elh, GOC:mah]"}
{"concept_id": "C1157897", "aliases": ["exonucleolytic degradation of DNA", "DNA degradation, exonucleolytic", "DNA breakdown, exonucleolytic"], "types": ["T045"], "canonical_name": "DNA catabolic process, exonucleolytic", "definition": "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. [GOC:elh, GOC:mah]"}
{"concept_id": "C1157898", "aliases": [], "types": ["T045"], "canonical_name": "DNA double-strand break processing", "definition": "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. [PMID:10357855]"}
{"concept_id": "C1157899", "aliases": ["heterocycle degradation", "heterocycle catabolism", "heterocycle breakdown"], "types": ["T044"], "canonical_name": "heterocycle catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). [GOC:ai]"}
{"concept_id": "C1157900", "aliases": ["hormone breakdown", "hormone catabolism", "hormone degradation"], "types": ["T044"], "canonical_name": "hormone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl]"}
{"concept_id": "C1157901", "aliases": ["androgen catabolism", "androgen degradation", "androgen breakdown"], "types": ["T044"], "canonical_name": "androgen catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]"}
{"concept_id": "C1157902", "aliases": ["auxin degradation", "auxin breakdown", "auxin catabolism"], "types": ["T044"], "canonical_name": "auxin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth. [GOC:lm, GOC:lr, ISBN:0198547684]"}
{"concept_id": "C1157903", "aliases": ["C21-steroid hormone degradation", "C21-steroid hormone breakdown", "C21-steroid hormone catabolism"], "types": ["T044"], "canonical_name": "C21-steroid hormone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. [GOC:ai]"}
{"concept_id": "C1157904", "aliases": ["progesterone catabolism", "progesterone breakdown", "progesterone degradation"], "types": ["T044"], "canonical_name": "progesterone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/]"}
{"concept_id": "C1157905", "aliases": ["ecdysteroid breakdown", "ecdysteroid degradation", "ecdysteroid catabolism"], "types": ["T044"], "canonical_name": "ecdysteroid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. [GOC:ai]"}
{"concept_id": "C1157906", "aliases": ["estrogen breakdown", "oestrogen catabolic process", "estrogen degradation", "oestrogen catabolism", "estrogen catabolism"], "types": ["T044"], "canonical_name": "estrogen catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]"}
{"concept_id": "C1157907", "aliases": ["glucocorticoid breakdown", "glucocorticoid catabolism", "glucocorticoid degradation"], "types": ["T044"], "canonical_name": "glucocorticoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]"}
{"concept_id": "C1157908", "aliases": ["juvenile hormone breakdown", "juvenile hormone catabolism", "juvenile hormone degradation"], "types": ["T044"], "canonical_name": "juvenile hormone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. [GOC:go_curators, ISBN:0198547684]"}
{"concept_id": "C1157909", "aliases": ["regulation of juvenile hormone catabolism", "regulation of juvenile hormone degradation", "regulation of juvenile hormone breakdown"], "types": ["T043"], "canonical_name": "regulation of juvenile hormone catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1157910", "aliases": ["negative regulation of juvenile hormone degradation", "down-regulation of juvenile hormone catabolic process", "downregulation of juvenile hormone catabolic process", "down regulation of juvenile hormone catabolic process", "negative regulation of juvenile hormone catabolism", "negative regulation of juvenile hormone breakdown"], "types": ["T043"], "canonical_name": "negative regulation of juvenile hormone catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1157911", "aliases": ["positive regulation of juvenile hormone breakdown", "up-regulation of juvenile hormone catabolic process", "positive regulation of juvenile hormone catabolism", "positive regulation of juvenile hormone degradation", "upregulation of juvenile hormone catabolic process", "up regulation of juvenile hormone catabolic process"], "types": ["T043"], "canonical_name": "positive regulation of juvenile hormone catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1157912", "aliases": ["mineralocorticoid breakdown", "mineralocorticoid degradation", "mineralocorticoid catabolism"], "types": ["T044"], "canonical_name": "mineralocorticoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]"}
{"concept_id": "C1157913", "aliases": ["ketone degradation", "ketone catabolism", "ketone breakdown"], "types": ["T044"], "canonical_name": "ketone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. [GOC:go_curators]"}
{"concept_id": "C1157914", "aliases": ["(+)-camphor catabolism", "(+)-camphor degradation", "(+)-camphor breakdown"], "types": ["T044"], "canonical_name": "(+)-camphor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone. [UM-BBD_pathwayID:cam]"}
{"concept_id": "C1157915", "aliases": ["acetoin catabolism", "acetoin degradation", "acetoin breakdown"], "types": ["T044"], "canonical_name": "acetoin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone. [GOC:mlg]"}
{"concept_id": "C1157916", "aliases": ["fatty acid degradation", "fatty acid catabolism", "fatty acid breakdown"], "types": ["T044"], "canonical_name": "fatty acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. [GOC:go_curators]"}
{"concept_id": "C1157917", "aliases": ["short-chain fatty acid breakdown", "short-chain fatty acid catabolism", "short-chain fatty acid degradation"], "types": ["T044"], "canonical_name": "short-chain fatty acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6. [ISBN:0198506732]"}
{"concept_id": "C1157918", "aliases": ["glycerolipid breakdown", "glycerolipid catabolism", "glycerolipid degradation"], "types": ["T044"], "canonical_name": "glycerolipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. [GOC:ai]"}
{"concept_id": "C1157919", "aliases": ["acylglycerol catabolism", "acylglycerol degradation", "acylglycerol breakdown"], "types": ["T044"], "canonical_name": "acylglycerol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. [GOC:ai]"}
{"concept_id": "C1157920", "aliases": ["diglyceride catabolism", "diacylglycerol degradation", "diacylglycerol catabolism", "diacylglycerol breakdown"], "types": ["T044"], "canonical_name": "diacylglycerol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [PMID:11717312]"}
{"concept_id": "C1157921", "aliases": ["CDP-diacylglycerol catabolism", "CDP-diacylglycerol breakdown", "CDP-diacylglycerol degradation"], "types": ["T044"], "canonical_name": "CDP-diacylglycerol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. [PMID:6147353]"}
{"concept_id": "C1157922", "aliases": ["triacylglycerol catabolism", "triglyceride degradation", "triglyceride catabolism", "triacylglycerol catabolic process", "triglyceride breakdown"], "types": ["T044"], "canonical_name": "triglyceride catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. [ISBN:0198506732]"}
{"concept_id": "C1157923", "aliases": ["hemiterpene catabolism", "isoprenoid catabolism", "2-methyl-1,3-butadiene catabolism", "isoprenoid breakdown", "isoprene catabolic process", "isoprenoid degradation", "hemiterpene catabolic process", "2-methyl-1,3-butadiene catabolic process"], "types": ["T044"], "canonical_name": "isoprenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198506732]"}
{"concept_id": "C1157924", "aliases": ["farnesyl diphosphate catabolism", "farnesyl diphosphate degradation", "farnesyl diphosphate breakdown"], "types": ["T044"], "canonical_name": "farnesyl diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate. [GOC:go_curators]"}
{"concept_id": "C1157925", "aliases": ["polyterpene catabolism", "polyterpene catabolic process"], "types": ["T044"], "canonical_name": "polyterpene catabolism"}
{"concept_id": "C1157926", "aliases": ["terpenoid breakdown", "terpenoid catabolism", "terpenoid degradation"], "types": ["T044"], "canonical_name": "terpenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. [GOC:ai]"}
{"concept_id": "C1157927", "aliases": ["diterpenoid degradation", "diterpenoid catabolism", "diterpenoid breakdown"], "types": ["T044"], "canonical_name": "diterpenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1157928", "aliases": ["gibberellic acid catabolism", "gibberellin catabolism", "gibberellic acid breakdown", "gibberellic acid degradation", "gibberellic acid catabolic process"], "types": ["T044"], "canonical_name": "gibberellin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators. [GOC:go_curators]"}
{"concept_id": "C1157929", "aliases": ["monoterpenoid breakdown", "monoterpenoid catabolism", "monoterpenoid degradation"], "types": ["T044"], "canonical_name": "monoterpenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton. [GOC:go_curators]"}
{"concept_id": "C1157930", "aliases": ["polyterpenoid catabolism", "polyterpenoid degradation", "polyterpenoid breakdown"], "types": ["T044"], "canonical_name": "polyterpenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units. [GOC:go_curators]"}
{"concept_id": "C1157931", "aliases": ["sesquiterpenoid catabolism", "sesquiterpenoid degradation", "sesquiterpenoid breakdown"], "types": ["T044"], "canonical_name": "sesquiterpenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units. [GOC:go_curators]"}
{"concept_id": "C1157932", "aliases": ["abscisic acid breakdown", "abscisic acid catabolism", "abscisic acid degradation"], "types": ["T044"], "canonical_name": "abscisic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. [GOC:ai]"}
{"concept_id": "C1157933", "aliases": ["tetraterpenoid degradation", "tetraterpenoid catabolism", "tetraterpenoid breakdown"], "types": ["T044"], "canonical_name": "tetraterpenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units. [GOC:go_curators]"}
{"concept_id": "C1157934", "aliases": ["carotenoid catabolism", "carotenoid degradation", "carotenoid breakdown"], "types": ["T044"], "canonical_name": "carotenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. [GOC:go_curators]"}
{"concept_id": "C1157935", "aliases": ["carotene breakdown", "carotene catabolism", "carotene degradation"], "types": ["T044"], "canonical_name": "carotene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids. [GOC:go_curators]"}
{"concept_id": "C1157936", "aliases": ["xanthophyll catabolism", "xanthophyll breakdown", "xanthophyll degradation"], "types": ["T044"], "canonical_name": "xanthophyll catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids. [GOC:go_curators]"}
{"concept_id": "C1157937", "aliases": ["triterpenoid catabolism", "triterpenoid breakdown", "triterpenoid degradation"], "types": ["T044"], "canonical_name": "triterpenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units. [GOC:go_curators]"}
{"concept_id": "C1157938", "aliases": ["pentacyclic triterpenoid breakdown", "pentacyclic triterpenoid catabolism", "pentacyclic triterpenoid degradation"], "types": ["T044"], "canonical_name": "pentacyclic triterpenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. [ISBN:0198506732]"}
{"concept_id": "C1157939", "aliases": ["hopanoid breakdown", "hopanoid catabolism", "hopanoid degradation"], "types": ["T044"], "canonical_name": "hopanoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. [ISBN:0198547684]"}
{"concept_id": "C1157940", "aliases": ["prenol degradation", "prenol catabolism", "prenol breakdown"], "types": ["T044"], "canonical_name": "prenol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail. [GOC:go_curators]"}
{"concept_id": "C1157941", "aliases": ["polyprenol breakdown", "polyprenol degradation", "polyprenol catabolism"], "types": ["T044"], "canonical_name": "polyprenol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. [GOC:go_curators, Wikipedia:Polyprenol]"}
{"concept_id": "C1157942", "aliases": ["membrane lipid catabolism", "membrane lipid breakdown", "membrane lipid degradation"], "types": ["T044"], "canonical_name": "membrane lipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. [GOC:ai]"}
{"concept_id": "C1157943", "aliases": ["glycolipid catabolism", "glycolipid degradation", "glycolipid breakdown"], "types": ["T044"], "canonical_name": "glycolipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). [GOC:go_curators]"}
{"concept_id": "C1157944", "aliases": ["galactolipid degradation", "galactolipid breakdown", "galactolipid catabolism"], "types": ["T044"], "canonical_name": "galactolipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. [ISBN:0198506732]"}
{"concept_id": "C1157945", "aliases": ["galactosylceramide catabolism", "galactosylceramide breakdown", "galactosylceramide degradation"], "types": ["T044"], "canonical_name": "galactosylceramide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. [GOC:ai]"}
{"concept_id": "C1157946", "aliases": ["glycosphingolipid degradation", "glycosphingolipid breakdown", "glycosphingolipid catabolism"], "types": ["T044"], "canonical_name": "glycosphingolipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [ISBN:0198506732]"}
{"concept_id": "C1157947", "aliases": ["ganglioside degradation", "ganglioside catabolism", "ganglioside breakdown"], "types": ["T044"], "canonical_name": "ganglioside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues. [ISBN:0198547684]"}
{"concept_id": "C1157948", "aliases": ["glycosylceramide breakdown", "glycosylceramide degradation", "glycosylceramide catabolism"], "types": ["T044"], "canonical_name": "glycosylceramide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. [GOC:ai]"}
{"concept_id": "C1157949", "aliases": ["glucosylceramide breakdown", "glucosylceramide degradation", "glucosylceramide catabolism"], "types": ["T044"], "canonical_name": "glucosylceramide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. [GOC:ai]"}
{"concept_id": "C1157950", "aliases": ["phospholipid breakdown", "phospholipid catabolism", "phospholipid degradation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]", "canonical_name": "phospholipid catabolic process"}
{"concept_id": "C1157951", "aliases": ["glycerophospholipid breakdown", "glycerophospholipid catabolism", "glycerophospholipid degradation", "phosphoglyceride catabolic process", "phosphoglyceride catabolism"], "types": ["T044"], "canonical_name": "glycerophospholipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. [ISBN:0198506732]"}
{"concept_id": "C1157952", "aliases": ["phosphatidylserine breakdown", "phosphatidylserine degradation", "phosphatidylserine catabolism"], "types": ["T044"], "canonical_name": "phosphatidylserine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. [ISBN:0198506732]"}
{"concept_id": "C1157953", "aliases": ["sphingomyelin catabolism", "sphingomyelin breakdown", "sphingomyelin degradation"], "types": ["T044"], "canonical_name": "sphingomyelin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]"}
{"concept_id": "C1157954", "aliases": ["sphingolipid catabolism", "sphingolipid degradation", "sphingolipid breakdown"], "types": ["T044"], "canonical_name": "sphingolipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1157955", "aliases": ["sphingoid breakdown", "sphingoid catabolism", "sphingoid degradation"], "types": ["T044"], "canonical_name": "sphingoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. [ISBN:0198506732]"}
{"concept_id": "C1157956", "aliases": ["ceramide degradation", "ceramide breakdown", "ceramide catabolism"], "types": ["T044"], "canonical_name": "ceramide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. [GOC:ai]"}
{"concept_id": "C1157957", "aliases": ["neutral lipid degradation", "neutral lipid breakdown", "neutral lipid catabolism"], "types": ["T044"], "canonical_name": "neutral lipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. [GOC:ai]"}
{"concept_id": "C1157958", "aliases": ["steroid degradation", "steroid breakdown", "steroid catabolism"], "types": ["T044"], "canonical_name": "steroid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [GOC:go_curators]"}
{"concept_id": "C1157959", "aliases": ["bile acid catabolism", "bile acid degradation", "bile acid breakdown"], "types": ["T044"], "canonical_name": "bile acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. [GOC:go_curators]"}
{"concept_id": "C1157960", "aliases": ["phytosteroid degradation", "phytosteroid catabolism", "phytosteroid breakdown"], "types": ["T044"], "canonical_name": "phytosteroid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi. [GOC:go_curators, GOC:mah]"}
{"concept_id": "C1157961", "aliases": ["brassinosteroid catabolism", "brassinosteroid breakdown", "brassinosteroid degradation"], "types": ["T044"], "canonical_name": "brassinosteroid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. [ISBN:0192801023]"}
{"concept_id": "C1157962", "aliases": ["biopolymer catabolic process", "macromolecule breakdown", "macromolecule catabolism", "macromolecule degradation"], "types": ["T044"], "canonical_name": "macromolecule catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:mah]"}
{"concept_id": "C1157963", "aliases": ["haemoglobin catabolism", "haemoglobin catabolic process", "hemoglobin degradation", "hemoglobin catabolism", "hemoglobin breakdown"], "types": ["T044"], "canonical_name": "hemoglobin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids. [GOC:jl, GOC:mb]"}
{"concept_id": "C1157965", "aliases": ["prenylated protein breakdown", "prenylated protein degradation", "prenylated protein catabolism"], "types": ["T044"], "canonical_name": "prenylated protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of prenylated proteins. [GOC:mah]"}
{"concept_id": "C1157967", "aliases": ["ATP-dependent proteolysis"], "types": ["T044"], "canonical_name": "ATP-dependent proteolysis", "definition": "OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP. [GOC:jl]"}
{"concept_id": "C1157968", "aliases": ["collagen degradation", "collagen catabolism", "collagen breakdown"], "types": ["T044"], "canonical_name": "collagen catabolic process", "definition": "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1157969", "aliases": ["glycoprotein catabolism", "glycoprotein catabolic process", "glycoprotein degradation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]", "canonical_name": "glycoprotein breakdown"}
{"concept_id": "C1157970", "aliases": ["glycopeptide catabolism", "glycopeptide degradation", "glycopeptide breakdown"], "types": ["T044"], "canonical_name": "glycopeptide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycopeptides, a compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1157971", "aliases": ["O-sialoglycoprotein degradation", "O-sialoglycoprotein breakdown", "O-sialoglycoprotein catabolism"], "types": ["T044"], "canonical_name": "O-sialoglycoprotein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities. [GOC:go_curators, PMID:8824323]"}
{"concept_id": "C1157972", "aliases": ["glycoprotein deglycosylation"], "types": ["T044"], "canonical_name": "protein deglycosylation", "definition": "The removal of sugar residues from a glycosylated protein. [GOC:mah]"}
{"concept_id": "C1157973", "aliases": ["lipoprotein catabolism", "lipoprotein degradation", "lipoprotein breakdown"], "types": ["T044"], "canonical_name": "lipoprotein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. [ISBN:0198506732]"}
{"concept_id": "C1157977", "aliases": ["mannoprotein catabolism", "mannoprotein breakdown", "mannoprotein degradation"], "types": ["T044"], "canonical_name": "mannoprotein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a mannoprotein, a protein that contains covalently bound mannose residues. [ISBN:0198506732]"}
{"concept_id": "C1157978", "aliases": ["ectodomain cleavage"], "types": ["T044"], "canonical_name": "membrane protein ectodomain proteolysis", "definition": "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). [GOC:jl, http://www.copewithcytokines.de/]"}
{"concept_id": "C1157979", "aliases": ["misfolded or incompletely synthesized protein breakdown", "misfolded or incompletely synthesized protein catabolic process", "degradation of misfolded or incompletely synthesized proteins", "protein quality control (PQC)", "misfolded or incompletely synthesized protein degradation", "misfolded or incompletely synthesized protein catabolism"], "types": ["T044"], "canonical_name": "protein quality control for misfolded or incompletely synthesized proteins", "definition": "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. [GOC:jl]"}
{"concept_id": "C1157980", "aliases": ["endoplasmic reticulum-associated ubiqutin-dependent protein catabolism", "ER-associated ubiquitin-dependent protein breakdown", "ER-associated ubiquitin-dependent protein catabolic process", "ubiquitin-dependent ERAD pathway", "ER-associated ubiquitin-dependent protein degradation", "ubiquitin-dependent proteasomal protein catabolism of ER proteins", "ERAD", "endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process"], "types": ["T044"], "definition": "The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]", "canonical_name": "ER-associated ubiquitin-dependent protein catabolism"}
{"concept_id": "C1157981", "aliases": ["modification-dependent proteolysis", "modification-dependent protein breakdown", "modification-dependent protein degradation", "modification-initiated proteolysis", "modification-initiated protein catabolic process", "modification-initiated protein catabolism", "modification-dependent protein catabolism"], "types": ["T044"], "canonical_name": "modification-dependent protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. [GOC:go_curators]"}
{"concept_id": "C1157988", "aliases": ["protein desumolation", "desumoylation"], "types": ["T044"], "canonical_name": "protein desumoylation", "definition": "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. [GOC:jl, PMID:11265250]"}
{"concept_id": "C1157990", "aliases": ["SUMO-protein conjugation", "small ubiquitin-related protein 1 conjugation", "protein sumoylation", "sumoylation"], "types": ["T044"], "definition": "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. [GOC:jl, PMID:11265250]", "canonical_name": "protein sumolation"}
{"concept_id": "C1157991", "aliases": ["ubiquitin-dependent protein catabolism", "ubiquitin-dependent protein degradation", "ubiquitin-dependent protein breakdown", "ubiquitin-dependent proteolysis"], "types": ["T044"], "canonical_name": "ubiquitin-dependent protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. [GOC:go_curators]"}
{"concept_id": "C1157993", "aliases": ["protein amino acid arginylation"], "types": ["T044"], "canonical_name": "protein arginylation", "definition": "The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway. [PMID:17896865]"}
{"concept_id": "C1157996", "aliases": ["protein deubiquitylation", "protein deubiquitination", "protein deubiquitinylation"], "types": ["T044"], "definition": "The removal of one or more ubiquitin groups from a protein. [GOC:ai]", "canonical_name": "deubiquitination"}
{"concept_id": "C1158003", "aliases": ["regulation of cellular protein catabolism", "regulation of cellular protein degradation", "regulation of protein degradation", "regulation of protein breakdown", "regulation of cellular protein catabolic process", "regulation of protein catabolism", "regulation of cellular protein breakdown"], "types": ["T043"], "canonical_name": "regulation of protein catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators, GOC:jl]"}
{"concept_id": "C1158004", "aliases": ["downregulation of cellular protein catabolism", "negative regulation of protein degradation", "negative regulation of protein catabolism", "down regulation of protein catabolic process", "down regulation of cellular protein catabolic process", "down-regulation of cellular protein breakdown", "down regulation of cellular protein degradation", "down-regulation of cellular protein catabolic process", "negative regulation of cellular protein breakdown", "down-regulation of cellular protein catabolism", "negative regulation of cellular protein degradation", "negative regulation of protein breakdown", "down regulation of cellular protein catabolism", "negative regulation of cellular protein catabolism", "downregulation of cellular protein degradation", "negative regulation of cellular protein catabolic process", "down-regulation of protein catabolic process", "downregulation of cellular protein breakdown", "down regulation of cellular protein breakdown", "downregulation of cellular protein catabolic process", "down-regulation of cellular protein degradation", "downregulation of protein catabolic process"], "types": ["T043"], "canonical_name": "negative regulation of protein catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]"}
{"concept_id": "C1158005", "aliases": ["positive regulation of cellular protein catabolic process", "up regulation of protein catabolic process", "upregulation of cellular protein breakdown", "up regulation of cellular protein breakdown", "positive regulation of cellular protein catabolism", "positive regulation of cellular protein degradation", "positive regulation of protein catabolism", "up regulation of cellular protein degradation", "upregulation of protein catabolic process", "up-regulation of cellular protein breakdown", "up-regulation of cellular protein degradation", "upregulation of cellular protein degradation", "positive regulation of protein breakdown", "up-regulation of cellular protein catabolic process", "positive regulation of cellular protein breakdown", "positive regulation of protein degradation", "upregulation of cellular protein catabolic process", "up regulation of cellular protein catabolism", "up regulation of cellular protein catabolic process", "up-regulation of cellular protein catabolism", "upregulation of cellular protein catabolism", "up-regulation of protein catabolic process"], "types": ["T043"], "canonical_name": "positive regulation of protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators]"}
{"concept_id": "C1158008", "aliases": ["nuclear mRNA catabolic process, deadenylation-dependent decay", "mRNA degradation, deadenylation-dependent decay", "mRNA catabolic process, deadenylylation-dependent", "mRNA catabolism, deadenylylation-dependent", "mRNA breakdown, deadenylation-dependent decay", "mRNA catabolic process, deadenylation-dependent", "deadenylation-dependent mRNA decay", "mRNA catabolism, deadenylation-dependent"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "definition": "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. [GOC:jp, GOC:krc]"}
{"concept_id": "C1158009", "aliases": ["deadenylation-dependent decapping of nuclear mRNA", "deadenylylation-dependent decapping"], "types": ["T045"], "canonical_name": "deadenylation-dependent decapping of nuclear-transcribed mRNA", "definition": "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length. [GOC:krc]"}
{"concept_id": "C1158010", "aliases": ["mRNA breakdown, exonucleolytic", "nuclear mRNA catabolic process, exonucleolytic", "mRNA degradation, exonucleolytic", "exonucleolytic degradation of mRNA"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, exonucleolytic", "definition": "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. [GOC:krc]"}
{"concept_id": "C1158012", "aliases": ["nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay", "mRNA degradation, endonucleolytic cleavage-dependent decay", "endonucleolytic mRNA decay", "mRNA catabolic process, endonucleolytic", "mRNA breakdown, endonucleolytic cleavage-dependent decay", "mRNA catabolism, endonucleolytic"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay", "definition": "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends. [GOC:krc]"}
{"concept_id": "C1158013", "aliases": ["mRNA breakdown, nonsense-mediated decay", "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "nuclear mRNA catabolic process, nonsense-mediated decay", "mRNA degradation, nonsense-mediated decay", "mRNA catabolism, nonsense-mediated", "nonsense-mediated mRNA decay"], "types": ["T045"], "definition": "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. [GOC:krc, GOC:ma, PMID:10025395]", "canonical_name": "mRNA catabolic process, nonsense-mediated"}
{"concept_id": "C1158014", "aliases": ["RNA fragment degradation", "RNA fragment catabolism", "RNA fragment breakdown"], "types": ["T045"], "canonical_name": "RNA fragment catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing. [GOC:mah]"}
{"concept_id": "C1158015", "aliases": [], "types": ["T045"], "canonical_name": "group I intron catabolic process"}
{"concept_id": "C1158016", "aliases": ["rRNA catabolism", "rRNA degradation", "rRNA breakdown"], "types": ["T045"], "canonical_name": "rRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. [GOC:ai]"}
{"concept_id": "C1158017", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA catabolic process"}
{"concept_id": "C1158018", "aliases": ["snRNA breakdown", "snRNA catabolism", "snRNA degradation"], "types": ["T045"], "canonical_name": "snRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. [ISBN:0198506732]"}
{"concept_id": "C1158019", "aliases": ["tRNA catabolism", "tRNA breakdown", "tRNA degradation"], "types": ["T045"], "canonical_name": "tRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. [GOC:ai]"}
{"concept_id": "C1158020", "aliases": ["nitric oxide breakdown", "nitric oxide degradation", "nitric oxide catabolism"], "types": ["T044"], "canonical_name": "nitric oxide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. [GOC:ai]"}
{"concept_id": "C1158021", "aliases": ["nucleoside breakdown", "nucleoside catabolism", "nucleoside degradation"], "types": ["T044"], "canonical_name": "nucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:jl]"}
{"concept_id": "C1158022", "aliases": ["purine nucleoside degradation", "purine nucleoside catabolism", "purine nucleoside breakdown"], "types": ["T044"], "canonical_name": "purine nucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:go_curators]"}
{"concept_id": "C1158024", "aliases": ["purine ribonucleoside catabolism", "purine ribonucleoside breakdown", "purine ribonucleoside degradation"], "types": ["T044"], "canonical_name": "purine ribonucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:ai]"}
{"concept_id": "C1158025", "aliases": ["adenosine breakdown", "adenosine degradation", "adenosine catabolism"], "types": ["T044"], "canonical_name": "adenosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. [GOC:go_curators]"}
{"concept_id": "C1158027", "aliases": [], "types": ["T044"], "canonical_name": "adenosine phosphorolysis"}
{"concept_id": "C1158028", "aliases": ["bis(5'-nucleosidyl) oligophosphate breakdown", "bis(5'-nucleosidyl) oligophosphate catabolism", "bis(5'-nucleosidyl) oligophosphate degradation"], "types": ["T044"], "canonical_name": "bis(5'-nucleosidyl) oligophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. [GOC:mah, PMID:10970777]"}
{"concept_id": "C1158029", "aliases": ["diadenosine polyphosphate breakdown", "diadenosine polyphosphate catabolism", "diadenosine polyphosphate degradation"], "types": ["T044"], "canonical_name": "diadenosine polyphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. [GOC:ai]"}
{"concept_id": "C1158030", "aliases": ["diadenosine tetraphosphate breakdown", "diadenosine tetraphosphate catabolism", "diadenosine tetraphosphate degradation"], "types": ["T044"], "canonical_name": "diadenosine tetraphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. [GOC:ai]"}
{"concept_id": "C1158031", "aliases": ["diadenosine triphosphate breakdown", "diadenosine triphosphate degradation", "diadenosine triphosphate catabolism"], "types": ["T044"], "canonical_name": "diadenosine triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. [GOC:ai]"}
{"concept_id": "C1158032", "aliases": ["guanosine degradation", "guanosine breakdown", "guanosine catabolism"], "types": ["T044"], "canonical_name": "guanosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution. [GOC:go_curators]"}
{"concept_id": "C1158033", "aliases": ["7-methylguanosine breakdown", "7-methylguanosine degradation", "7-methylguanosine catabolism"], "types": ["T044"], "canonical_name": "7-methylguanosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA. [ISBN:0198506732]"}
{"concept_id": "C1158034", "aliases": ["queuosine breakdown", "queuosine catabolism", "queuosine degradation"], "types": ["T044"], "canonical_name": "queuosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. [ISBN:0198506732]"}
{"concept_id": "C1158035", "aliases": ["guanosine pentaphosphate (5'-pppGpp-3') catabolism", "guanosine pentaphosphate degradation", "guanosine pentaphosphate (5'-pppGpp-3') catabolic process", "guanosine pentaphosphate catabolism", "guanosine pentaphosphate breakdown"], "types": ["T044"], "canonical_name": "guanosine pentaphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. [GOC:ai]"}
{"concept_id": "C1158036", "aliases": ["guanosine tetraphosphate catabolism", "guanosine tetraphosphate breakdown", "guanosine tetraphosphate (5'-ppGpp-3') catabolic process", "guanosine tetraphosphate degradation", "guanosine tetraphosphate (5'-ppGpp-3') catabolism"], "types": ["T044"], "canonical_name": "guanosine tetraphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. [GOC:ai]"}
{"concept_id": "C1158037", "aliases": ["pyrimidine nucleoside catabolism", "pyrimidine nucleoside degradation", "pyrimidine nucleoside breakdown"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1158038", "aliases": ["pyrimidine ribonucleoside catabolism", "pyrimidine ribonucleoside degradation", "pyrimidine ribonucleoside breakdown"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:ai]"}
{"concept_id": "C1158039", "aliases": ["cytidine degradation", "cytidine breakdown", "cytidine catabolism"], "types": ["T044"], "canonical_name": "cytidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside. [GOC:ai]"}
{"concept_id": "C1158040", "aliases": ["inosine breakdown", "inosine degradation", "inosine catabolism"], "types": ["T044"], "canonical_name": "inosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. [GOC:go_curators]"}
{"concept_id": "C1158041", "aliases": ["uridine breakdown", "uridine degradation", "uridine catabolism"], "types": ["T044"], "canonical_name": "uridine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. [GOC:go_curators]"}
{"concept_id": "C1158042", "aliases": ["nucleotide breakdown", "nucleotide catabolism", "nucleotide degradation"], "types": ["T044"], "canonical_name": "nucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). [GOC:go_curators]"}
{"concept_id": "C1158043", "aliases": ["cyclic nucleotide breakdown", "cyclic nucleotide catabolism", "cyclic nucleotide degradation"], "types": ["T044"], "canonical_name": "cyclic nucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158044", "aliases": ["adenosine 3',5'-cyclophosphate catabolism", "3',5' cAMP catabolic process", "adenosine 3',5'-cyclophosphate catabolic process", "3',5' cAMP catabolism", "cAMP degradation", "cyclic AMP catabolism", "cAMP breakdown", "cyclic AMP catabolic process", "3',5'-cAMP catabolism", "3',5'-cAMP catabolic process", "cAMP catabolism"], "types": ["T044"], "canonical_name": "cAMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). [ISBN:0198506732]"}
{"concept_id": "C1158045", "aliases": ["cGMP catabolism", "cGMP breakdown", "cGMP degradation"], "types": ["T044"], "canonical_name": "cGMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate. [GOC:go_curators]"}
{"concept_id": "C1158046", "aliases": ["deoxyribonucleotide catabolism", "deoxyribonucleotide breakdown", "deoxyribonucleotide degradation"], "types": ["T044"], "canonical_name": "deoxyribonucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158047", "aliases": ["deoxyribonucleoside diphosphate catabolism", "deoxyribonucleoside diphosphate breakdown", "deoxyribonucleoside diphosphate degradation"], "types": ["T044"], "canonical_name": "deoxyribonucleoside diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158048", "aliases": ["purine deoxyribonucleoside diphosphate degradation", "purine deoxyribonucleoside diphosphate catabolism", "purine deoxyribonucleoside diphosphate breakdown"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158049", "aliases": ["dADP degradation", "dADP breakdown", "dADP catabolism"], "types": ["T044"], "canonical_name": "dADP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). [GOC:go_curators]"}
{"concept_id": "C1158050", "aliases": ["dGDP breakdown", "dGDP catabolism", "dGDP degradation"], "types": ["T044"], "canonical_name": "dGDP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). [GOC:go_curators]"}
{"concept_id": "C1158051", "aliases": ["pyrimidine deoxyribonucleoside diphosphate breakdown", "pyrimidine deoxyribonucleoside diphosphate degradation", "pyrimidine deoxyribonucleoside diphosphate catabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158052", "aliases": ["dCDP breakdown", "dCDP catabolism", "dCDP degradation"], "types": ["T044"], "canonical_name": "dCDP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1158053", "aliases": ["dTDP degradation", "dTDP breakdown", "dTDP catabolism"], "types": ["T044"], "canonical_name": "dTDP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1158054", "aliases": ["dUDP catabolism", "dUDP breakdown", "dUDP degradation"], "types": ["T044"], "canonical_name": "dUDP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1158055", "aliases": ["deoxyribonucleoside monophosphate breakdown", "deoxyribonucleoside monophosphate catabolism", "deoxyribonucleoside monophosphate degradation"], "types": ["T044"], "canonical_name": "deoxyribonucleoside monophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158056", "aliases": ["purine deoxyribonucleoside monophosphate degradation", "purine deoxyribonucleoside monophosphate catabolism", "purine deoxyribonucleoside monophosphate breakdown"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside monophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158057", "aliases": ["dAMP degradation", "dAMP breakdown", "dAMP catabolism"], "types": ["T044"], "canonical_name": "dAMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). [GOC:go_curators]"}
{"concept_id": "C1158058", "aliases": ["dGMP catabolism", "dGMP degradation", "dGMP breakdown"], "types": ["T044"], "canonical_name": "dGMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). [GOC:go_curators]"}
{"concept_id": "C1158059", "aliases": ["pyrimidine deoxyribonucleoside monophosphate breakdown", "pyrimidine deoxyribonucleoside monophosphate degradation", "pyrimidine deoxyribonucleoside monophosphate catabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside monophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158060", "aliases": ["dCMP breakdown", "dCMP degradation", "dCMP catabolism"], "types": ["T044"], "canonical_name": "dCMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1158061", "aliases": ["dTMP catabolism", "dTMP degradation", "dTMP breakdown"], "types": ["T044"], "canonical_name": "dTMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158062", "aliases": ["dUMP breakdown", "dUMP degradation", "dUMP catabolism"], "types": ["T044"], "canonical_name": "dUMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158063", "aliases": ["deoxyribonucleoside triphosphate degradation", "deoxyribonucleoside triphosphate breakdown", "deoxyribonucleoside triphosphate catabolism"], "types": ["T044"], "canonical_name": "deoxyribonucleoside triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158064", "aliases": ["purine deoxyribonucleoside triphosphate breakdown", "purine deoxyribonucleoside triphosphate catabolism", "purine deoxyribonucleoside triphosphate degradation"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158065", "aliases": ["dATP breakdown", "dATP catabolism", "dATP degradation"], "types": ["T044"], "canonical_name": "dATP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). [GOC:go_curators]"}
{"concept_id": "C1158066", "aliases": ["dGTP catabolism", "dGTP breakdown", "dGTP degradation"], "types": ["T044"], "canonical_name": "dGTP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1158067", "aliases": ["pyrimidine deoxyribonucleoside triphosphate catabolism", "pyrimidine deoxyribonucleoside triphosphate breakdown", "pyrimidine deoxyribonucleoside triphosphate degradation"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158068", "aliases": ["dCTP breakdown", "dCTP catabolism", "dCTP degradation"], "types": ["T044"], "canonical_name": "dCTP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1158069", "aliases": ["dTTP degradation", "dTTP breakdown", "dTTP catabolism"], "types": ["T044"], "canonical_name": "dTTP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158070", "aliases": ["dUTP degradation", "dUTP breakdown", "dUTP catabolism"], "types": ["T044"], "canonical_name": "dUTP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158071", "aliases": ["purine deoxyribonucleotide catabolism", "purine deoxyribonucleotide breakdown", "purine deoxyribonucleotide degradation"], "types": ["T044"], "canonical_name": "purine deoxyribonucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158072", "aliases": ["pyrimidine deoxyribonucleotide degradation", "pyrimidine deoxyribonucleotide breakdown", "pyrimidine deoxyribonucleotide catabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158073", "aliases": ["nucleoside diphosphate degradation", "nucleoside diphosphate catabolism", "nucleoside diphosphate breakdown"], "types": ["T044"], "canonical_name": "nucleoside diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158074", "aliases": ["purine nucleoside diphosphate catabolism", "purine nucleoside diphosphate breakdown", "purine nucleoside diphosphate degradation"], "types": ["T044"], "canonical_name": "purine nucleoside diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158075", "aliases": ["purine ribonucleoside diphosphate catabolism", "purine ribonucleoside diphosphate degradation", "purine ribonucleoside diphosphate breakdown"], "types": ["T044"], "canonical_name": "purine ribonucleoside diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158076", "aliases": ["ADP breakdown", "ADP degradation", "ADP catabolism"], "types": ["T044"], "canonical_name": "ADP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate. [GOC:go_curators]"}
{"concept_id": "C1158077", "aliases": [], "types": ["T044"], "canonical_name": "ADP reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1158078", "aliases": ["GDP catabolism", "GDP breakdown", "GDP degradation"], "types": ["T044"], "canonical_name": "GDP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate. [GOC:ai]"}
{"concept_id": "C1158079", "aliases": ["IDP degradation", "IDP catabolism", "IDP breakdown"], "types": ["T044"], "canonical_name": "IDP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate. [GOC:ai]"}
{"concept_id": "C1158080", "aliases": ["pyrimidine nucleoside diphosphate catabolism", "pyrimidine nucleoside diphosphate breakdown", "pyrimidine nucleoside diphosphate degradation"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158081", "aliases": ["pyrimidine ribonucleoside diphosphate degradation", "pyrimidine ribonucleoside diphosphate breakdown", "pyrimidine ribonucleoside diphosphate catabolism"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158082", "aliases": ["CDP catabolism", "CDP breakdown", "CDP degradation"], "types": ["T044"], "canonical_name": "CDP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate. [GOC:ai]"}
{"concept_id": "C1158083", "aliases": [], "types": ["T044"], "canonical_name": "CDP reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1158084", "aliases": ["TDP catabolism", "TDP degradation", "TDP breakdown"], "types": ["T044"], "canonical_name": "TDP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1158085", "aliases": ["UDP breakdown", "UDP degradation", "UDP catabolism"], "types": ["T044"], "canonical_name": "UDP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate. [ISBN:0198506732]"}
{"concept_id": "C1158086", "aliases": [], "types": ["T044"], "canonical_name": "UDP reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1158087", "aliases": ["ribonucleoside diphosphate catabolism", "ribonucleoside diphosphate breakdown", "ribonucleoside diphosphate degradation"], "types": ["T044"], "canonical_name": "ribonucleoside diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158088", "aliases": ["nucleoside monophosphate breakdown", "nucleoside monophosphate catabolism", "nucleoside monophosphate degradation"], "types": ["T044"], "canonical_name": "nucleoside monophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158089", "aliases": ["purine nucleoside monophosphate breakdown", "purine nucleoside monophosphate catabolism", "purine nucleoside monophosphate degradation"], "types": ["T044"], "canonical_name": "purine nucleoside monophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158090", "aliases": ["purine ribonucleoside monophosphate breakdown", "purine ribonucleoside monophosphate catabolism", "purine ribonucleoside monophosphate degradation"], "types": ["T044"], "canonical_name": "purine ribonucleoside monophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158091", "aliases": ["AMP degradation", "AMP breakdown", "AMP catabolism"], "types": ["T044"], "canonical_name": "AMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1158093", "aliases": ["GMP catabolism", "GMP breakdown", "GMP degradation"], "types": ["T044"], "canonical_name": "GMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158094", "aliases": ["GMP degradation to IMP", "GMP breakdown to IMP"], "types": ["T044"], "canonical_name": "GMP catabolic process to IMP", "definition": "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1158095", "aliases": ["IMP degradation", "IMP catabolism", "IMP breakdown"], "types": ["T044"], "canonical_name": "IMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1158096", "aliases": ["pyrimidine nucleoside monophosphate catabolism", "pyrimidine nucleoside monophosphate degradation", "pyrimidine nucleoside monophosphate breakdown"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside monophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158097", "aliases": ["pyrimidine ribonucleoside monophosphate degradation", "pyrimidine ribonucleoside monophosphate catabolism", "pyrimidine ribonucleoside monophosphate breakdown"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside monophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158098", "aliases": ["CMP degradation", "CMP breakdown", "CMP catabolism"], "types": ["T044"], "canonical_name": "CMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate. [ISBN:0198506732]"}
{"concept_id": "C1158099", "aliases": ["TMP degradation", "TMP catabolism", "TMP breakdown"], "types": ["T044"], "canonical_name": "TMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158100", "aliases": ["UMP catabolism", "UMP breakdown", "UMP degradation"], "types": ["T044"], "canonical_name": "UMP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158101", "aliases": ["ribonucleoside monophosphate degradation", "ribonucleoside monophosphate breakdown", "ribonucleoside monophosphate catabolism"], "types": ["T044"], "canonical_name": "ribonucleoside monophosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158102", "aliases": ["nucleoside triphosphate catabolism", "nucleoside triphosphate breakdown", "nucleoside triphosphate degradation"], "types": ["T044"], "canonical_name": "nucleoside triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158103", "aliases": ["purine nucleoside triphosphate breakdown", "purine nucleoside triphosphate catabolism", "purine nucleoside triphosphate degradation"], "types": ["T044"], "canonical_name": "purine nucleoside triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158104", "aliases": ["purine ribonucleoside triphosphate catabolism", "purine ribonucleoside triphosphate breakdown", "purine ribonucleoside triphosphate degradation"], "types": ["T044"], "canonical_name": "purine ribonucleoside triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158107", "aliases": ["ITP breakdown", "ITP hydrolysis", "ITP degradation", "ITP catabolism"], "types": ["T044"], "canonical_name": "ITP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1158108", "aliases": ["pyrimidine nucleoside triphosphate breakdown", "pyrimidine nucleoside triphosphate catabolism", "pyrimidine nucleoside triphosphate degradation"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158109", "aliases": ["pyrimidine ribonucleoside triphosphate breakdown", "pyrimidine ribonucleoside triphosphate degradation", "pyrimidine ribonucleoside triphosphate catabolism"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158110", "aliases": ["CTP catabolism", "CTP breakdown", "CTP degradation", "CTP hydrolysis"], "types": ["T044"], "canonical_name": "CTP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate. [ISBN:0198506732]"}
{"concept_id": "C1158111", "aliases": [], "types": ["T044"], "canonical_name": "CTP deamination"}
{"concept_id": "C1158112", "aliases": [], "types": ["T044"], "canonical_name": "CTP reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1158113", "aliases": ["TTP hydrolysis", "TTP catabolism", "TTP breakdown", "TTP degradation"], "types": ["T044"], "canonical_name": "TTP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158114", "aliases": [], "types": ["T044"], "canonical_name": "TTP reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1158115", "aliases": ["UTP degradation", "UTP breakdown", "UTP catabolism", "UTP hydrolysis"], "types": ["T044"], "canonical_name": "UTP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158116", "aliases": ["ribonucleoside triphosphate breakdown", "ribonucleoside triphosphate degradation", "ribonucleoside triphosphate catabolism"], "types": ["T044"], "canonical_name": "ribonucleoside triphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158117", "aliases": ["purine nucleotide degradation", "purine nucleotide breakdown", "purine nucleotide catabolism"], "types": ["T044"], "canonical_name": "purine nucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158118", "aliases": ["purine ribonucleotide degradation", "purine ribonucleotide breakdown", "purine ribonucleotide catabolism"], "types": ["T044"], "canonical_name": "purine ribonucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158119", "aliases": ["pyrimidine nucleotide degradation", "pyrimidine nucleotide breakdown", "pyrimidine nucleotide catabolism"], "types": ["T044"], "canonical_name": "pyrimidine nucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158120", "aliases": ["pyrimidine ribonucleotide breakdown", "pyrimidine ribonucleotide catabolism", "pyrimidine ribonucleotide degradation"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158121", "aliases": ["ribonucleotide degradation", "ribonucleotide catabolism", "ribonucleotide breakdown"], "types": ["T044"], "canonical_name": "ribonucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158122", "aliases": ["nucleotide-sugar degradation", "nucleotide-sugar catabolism", "nucleotide-sugar breakdown"], "types": ["T044"], "canonical_name": "nucleotide-sugar catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [ISBN:0198506732]"}
{"concept_id": "C1158124", "aliases": ["cyanate breakdown", "cyanate degradation", "cyanate catabolism"], "types": ["T044"], "canonical_name": "cyanate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid. [ISBN:0198506732]"}
{"concept_id": "C1158125", "aliases": ["cyanide breakdown", "cyanide catabolism", "cyanide degradation"], "types": ["T044"], "canonical_name": "cyanide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. [ISBN:0198506732]"}
{"concept_id": "C1158126", "aliases": ["formate catabolism", "formate degradation", "formic acid catabolic process", "formic acid catabolism", "formate breakdown"], "types": ["T044"], "canonical_name": "formate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. [ISBN:0198506732]"}
{"concept_id": "C1158127", "aliases": ["methane catabolism", "methane breakdown", "methane degradation"], "types": ["T044"], "canonical_name": "methane catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. [GOC:ai]"}
{"concept_id": "C1158128", "aliases": ["organic acid catabolism", "organic acid breakdown", "organic acid degradation"], "types": ["T044"], "canonical_name": "organic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. [ISBN:0198506732]"}
{"concept_id": "C1158129", "aliases": ["carboxylic acid breakdown", "carboxylic acid catabolism", "carboxylic acid degradation"], "types": ["T044"], "canonical_name": "carboxylic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. [ISBN:0198506732]"}
{"concept_id": "C1158131", "aliases": ["polyketide catabolism", "polyketide breakdown", "polyketide degradation"], "types": ["T044"], "canonical_name": "polyketide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1158132", "aliases": ["acetyl-CoA degradation", "acetyl-CoA breakdown", "acetyl-CoA catabolism"], "types": ["T044"], "canonical_name": "acetyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. [GOC:ai]"}
{"concept_id": "C1158133", "aliases": ["regulation of acetate catabolism", "regulation of acetate degradation", "regulation of acetate breakdown"], "types": ["T043"], "canonical_name": "regulation of acetate catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. [GOC:go_curators]"}
{"concept_id": "C1158134", "aliases": ["down regulation of acetate catabolic process", "down-regulation of acetate catabolic process", "negative regulation of acetate degradation", "negative regulation of acetate breakdown", "negative regulation of acetate catabolism", "downregulation of acetate catabolic process"], "types": ["T043"], "canonical_name": "negative regulation of acetate catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. [GOC:go_curators]"}
{"concept_id": "C1158135", "aliases": ["positive regulation of acetate catabolism", "positive regulation of acetate breakdown", "up-regulation of acetate catabolic process", "upregulation of acetate catabolic process", "positive regulation of acetate degradation", "up regulation of acetate catabolic process"], "types": ["T043"], "canonical_name": "positive regulation of acetate catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. [GOC:go_curators]"}
{"concept_id": "C1158136", "aliases": ["aldaric acid breakdown", "aldaric acid catabolism", "aldaric acid degradation"], "types": ["T044"], "canonical_name": "aldaric acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. [ISBN:0198506732]"}
{"concept_id": "C1158137", "aliases": ["galactarate catabolism", "galactarate degradation", "galactarate breakdown"], "types": ["T044"], "canonical_name": "galactarate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid. [GOC:ai, GOC:pr]"}
{"concept_id": "C1158138", "aliases": ["D-galactarate breakdown", "D-galactarate degradation", "D-galactarate catabolic process"], "types": ["T044"], "canonical_name": "D-galactarate catabolism"}
{"concept_id": "C1158139", "aliases": ["glucarate catabolism", "glucarate breakdown", "glucarate degradation"], "types": ["T044"], "canonical_name": "glucarate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid. [ISBN:0198506732]"}
{"concept_id": "C1158140", "aliases": ["butanoic acid catabolic process", "butyrate catabolism", "butanoic acid breakdown", "butanoic acid catabolism", "butyrate degradation", "butanoic acid degradation", "butyrate breakdown"], "types": ["T044"], "canonical_name": "butyrate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid. [ISBN:0198506732]"}
{"concept_id": "C1158141", "aliases": ["2-oxobutyrate degradation", "2-oxobutyrate breakdown", "alpha-ketobutyrate catabolism", "alpha-ketobutyrate catabolic process", "2-oxobutyrate catabolism"], "types": ["T044"], "canonical_name": "2-oxobutyrate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. [ISBN:0198506732]"}
{"concept_id": "C1158142", "aliases": ["galactonate breakdown", "galactonate degradation", "galactonate catabolism"], "types": ["T044"], "canonical_name": "galactonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid. [GOC:ai]"}
{"concept_id": "C1158143", "aliases": ["galacturonate catabolism", "galacturonate breakdown", "galacturonate degradation"], "types": ["T044"], "canonical_name": "galacturonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid. [GOC:ai]"}
{"concept_id": "C1158144", "aliases": ["D-galacturonate catabolism", "D-galacturonate degradation", "D-galacturonate breakdown"], "types": ["T044"], "canonical_name": "D-galacturonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1158145", "aliases": ["glucuronate degradation", "glucuronate catabolism", "glucuronate breakdown"], "types": ["T044"], "canonical_name": "glucuronate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. [GOC:go_curators]"}
{"concept_id": "C1158146", "aliases": ["glucuronate degradation to xylulose 5-phosphate", "glucuronate breakdown to xylulose 5-phosphate"], "types": ["T044"], "canonical_name": "glucuronate catabolic process to xylulose 5-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate. [GOC:go_curators]"}
{"concept_id": "C1158147", "aliases": ["propionate breakdown", "propionate degradation", "propionate catabolism"], "types": ["T044"], "canonical_name": "propionate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid. [GOC:go_curators]"}
{"concept_id": "C1158148", "aliases": ["propionate degradation, 2-methylcitrate cycle", "propionate breakdown, 2-methylcitrate cycle"], "types": ["T044"], "canonical_name": "propionate catabolic process, 2-methylcitrate cycle", "definition": "The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle. [GOC:go_curators]"}
{"concept_id": "C1158149", "aliases": ["shikimate breakdown", "shikimate catabolism", "shikimate degradation"], "types": ["T044"], "canonical_name": "shikimate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. [GOC:go_curators]"}
{"concept_id": "C1158150", "aliases": ["organomercury catabolism", "organomercury breakdown", "organomercury degradation"], "types": ["T044"], "canonical_name": "organomercury catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom. [GOC:ai]"}
{"concept_id": "C1158151", "aliases": ["methylmercury catabolism", "methylmercury degradation", "methylmercury breakdown"], "types": ["T044"], "canonical_name": "methylmercury catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal. [GOC:ai]"}
{"concept_id": "C1158152", "aliases": ["pigment breakdown", "pigment catabolism", "pigment degradation"], "types": ["T044"], "canonical_name": "pigment catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. [ISBN:0198506732]"}
{"concept_id": "C1158153", "aliases": ["eye pigment degradation", "eye pigment breakdown", "eye pigment catabolism"], "types": ["T044"], "canonical_name": "eye pigment catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. [GOC:ai]"}
{"concept_id": "C1158154", "aliases": ["rhodopsin catabolism", "rhodopsin breakdown", "rhodopsin degradation"], "types": ["T044"], "canonical_name": "rhodopsin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. [ISBN:0198506732]"}
{"concept_id": "C1158155", "aliases": ["melanin degradation", "melanin breakdown", "melanin catabolism"], "types": ["T044"], "canonical_name": "melanin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. [ISBN:0198506732]"}
{"concept_id": "C1158156", "aliases": ["ocellus pigment breakdown", "ocellus pigment catabolism", "ocellus pigment degradation"], "types": ["T044"], "canonical_name": "ocellus pigment catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. [GOC:ai, PMID:15176085, PMID:18421706]"}
{"concept_id": "C1158157", "aliases": ["polyphosphate degradation", "polyphosphate catabolism", "polyphosphate breakdown"], "types": ["T044"], "canonical_name": "polyphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158158", "aliases": ["regulation of catabolism", "regulation of degradation", "regulation of breakdown"], "types": ["T044"], "canonical_name": "regulation of catabolic process", "definition": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. [GOC:go_curators]"}
{"concept_id": "C1158159", "aliases": ["negative regulation of catabolism", "negative regulation of degradation", "downregulation of catabolic process", "down-regulation of catabolic process", "negative regulation of breakdown", "down regulation of catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. [GOC:go_curators]"}
{"concept_id": "C1158160", "aliases": ["positive regulation of catabolism", "upregulation of catabolic process", "positive regulation of degradation", "up-regulation of catabolic process", "positive regulation of breakdown", "up regulation of catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. [GOC:go_curators]"}
{"concept_id": "C1158161", "aliases": ["regulation of glycolysis involved in cellular glucose homeostasis"], "types": ["T043"], "canonical_name": "regulation of glycolytic process", "definition": "Any process that modulates the frequency, rate or extent of glycolysis. [GOC:go_curators]"}
{"concept_id": "C1158162", "aliases": ["down-regulation of glycolysis", "down regulation of glycolysis", "downregulation of glycolysis"], "types": ["T043"], "canonical_name": "negative regulation of glycolytic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. [GOC:go_curators]"}
{"concept_id": "C1158163", "aliases": ["up-regulation of glycolysis", "up regulation of glycolysis", "upregulation of glycolysis"], "types": ["T043"], "canonical_name": "positive regulation of glycolytic process", "definition": "Any process that activates or increases the frequency, rate or extent of glycolysis. [GOC:go_curators]"}
{"concept_id": "C1158164", "aliases": ["ribonucleoside catabolism", "ribonucleoside degradation", "ribonucleoside breakdown"], "types": ["T044"], "canonical_name": "ribonucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:jl]"}
{"concept_id": "C1158165", "aliases": ["terpene catabolism", "terpene degradation", "terpene breakdown"], "types": ["T044"], "canonical_name": "terpene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units. [GOC:ai]"}
{"concept_id": "C1158166", "aliases": ["alpha-pinene catabolism", "alpha-pinene degradation", "alpha-pinene breakdown"], "types": ["T044"], "canonical_name": "alpha-pinene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. [GOC:ai]"}
{"concept_id": "C1158167", "aliases": ["limonene breakdown", "limonene catabolism", "limonene degradation"], "types": ["T044"], "canonical_name": "limonene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. [GOC:ai]"}
{"concept_id": "C1158168", "aliases": ["urate catabolism", "urate degradation", "uric acid catabolic process", "urate breakdown"], "types": ["T044"], "canonical_name": "urate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine. [ISBN:0198506732]"}
{"concept_id": "C1158169", "aliases": ["vitamin degradation", "vitamin breakdown", "vitamin catabolism"], "types": ["T044"], "canonical_name": "vitamin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]"}
{"concept_id": "C1158170", "aliases": ["fat-soluble vitamin catabolism", "fat-soluble vitamin degradation", "fat-soluble vitamin breakdown"], "types": ["T044"], "canonical_name": "fat-soluble vitamin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1158171", "aliases": ["vitamin D degradation", "vitamin D catabolism", "calciferol catabolic process", "calciferol catabolism", "vitamin D breakdown"], "types": ["T044"], "canonical_name": "vitamin D catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]"}
{"concept_id": "C1158172", "aliases": ["water-soluble vitamin breakdown", "water-soluble vitamin catabolism", "water-soluble vitamin degradation"], "types": ["T044"], "canonical_name": "water-soluble vitamin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]"}
{"concept_id": "C1158173", "aliases": ["vitamin B7 catabolism", "vitamin B7 catabolic process", "biotin degradation", "biotin catabolism", "biotin breakdown", "vitamin H catabolic process", "vitamin H catabolism"], "types": ["T044"], "canonical_name": "biotin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. [ISBN:0198506732]"}
{"concept_id": "C1158174", "aliases": ["L-ascorbic acid breakdown", "vitamin C catabolic process", "ascorbate catabolism", "vitamin C catabolism", "L-ascorbic acid degradation", "L-ascorbic acid catabolism", "ascorbate catabolic process"], "types": ["T044"], "canonical_name": "L-ascorbic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. [GOC:go_curators]"}
{"concept_id": "C1158175", "aliases": ["thiamin catabolic process", "vitamin B1 catabolism", "thiamine degradation", "thiamine breakdown", "vitamin B1 catabolic process", "thiamine catabolism"], "types": ["T044"], "canonical_name": "thiamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1158176", "aliases": ["vitamin B2 catabolism", "vitamin G catabolism", "vitamin B2 catabolic process", "riboflavin catabolism", "riboflavin breakdown", "riboflavin degradation", "vitamin G catabolic process"], "types": ["T044"], "canonical_name": "riboflavin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]"}
{"concept_id": "C1158177", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme and prosthetic group metabolism"}
{"concept_id": "C1158179", "aliases": ["2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism"], "types": ["T044"], "canonical_name": "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process", "definition": "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A. [GOC:ai]"}
{"concept_id": "C1158180", "aliases": ["acetyl coenzyme A metabolic process", "acetyl coenzyme A metabolism", "acetyl-CoA metabolism"], "types": ["T044"], "canonical_name": "acetyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. [ISBN:0198547684]"}
{"concept_id": "C1158182", "aliases": ["acyl-CoA metabolism"], "types": ["T044"], "canonical_name": "acyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. [ISBN:0198506732]"}
{"concept_id": "C1158183", "aliases": ["ATP metabolism"], "types": ["T044"], "canonical_name": "ATP metabolic process", "definition": "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]"}
{"concept_id": "C1158184", "aliases": ["coenzyme B metabolism"], "types": ["T044"], "canonical_name": "coenzyme B metabolic process", "definition": "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. [GOC:go_curators]"}
{"concept_id": "C1158185", "aliases": ["coenzyme M metabolism"], "types": ["T044"], "canonical_name": "coenzyme M metabolic process", "definition": "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. [GOC:go_curators]"}
{"concept_id": "C1158186", "aliases": ["oxidized flavin-adenine dinucleotide metabolic process", "FAD metabolism", "oxidized flavin adenine dinucleotide metabolic process", "oxidized flavin-adenine dinucleotide metabolism", "oxidized flavin adenine dinucleotide metabolism"], "types": ["T044"], "canonical_name": "FAD metabolic process", "definition": "The chemical reactions and pathways involving FAD, the oxidized form of flavin adenine dinucleotide. [PMID:20822113]"}
{"concept_id": "C1158187", "aliases": ["FMN metabolism"], "types": ["T044"], "canonical_name": "FMN metabolic process", "definition": "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase. [GOC:ai, PMID:20822113]"}
{"concept_id": "C1158188", "aliases": ["glutathione metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. [ISBN:0198506732]", "canonical_name": "glutathione metabolism"}
{"concept_id": "C1158190", "aliases": ["coenzyme A metabolism", "CoA metabolism"], "types": ["T044"], "canonical_name": "coenzyme A metabolic process", "definition": "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [ISBN:0198547684]"}
{"concept_id": "C1158191", "aliases": ["nucleoside phosphate metabolism"], "types": ["T044"], "canonical_name": "nucleoside phosphate metabolic process", "definition": "The chemical reactions and pathways involving any phosphorylated nucleoside. [GOC:mah]"}
{"concept_id": "C1158192", "aliases": ["vitamin B5 metabolism", "pantothenate metabolism", "vitamin B5 metabolic process"], "types": ["T044"], "canonical_name": "pantothenate metabolic process", "definition": "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. [GOC:ai, ISBN:0721662544]"}
{"concept_id": "C1158193", "aliases": ["iron-sulfur cluster biosynthesis", "iron-sulphur cluster assembly"], "types": ["T044"], "canonical_name": "iron-sulfur cluster assembly", "definition": "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. [GOC:jl, GOC:mah, GOC:pde, GOC:vw]"}
{"concept_id": "C1158194", "aliases": ["L-methylmalonyl-CoA metabolism"], "types": ["T044"], "canonical_name": "L-methylmalonyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals. [GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1158195", "aliases": ["lipoamide metabolism"], "types": ["T044"], "canonical_name": "lipoamide metabolic process", "definition": "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group. [GOC:go_curators]"}
{"concept_id": "C1158197", "aliases": ["lipoate metabolic process", "lipoate metabolism", "lipoic acid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. [GOC:ai, ISBN:0198506732]", "canonical_name": "lipoic acid metabolic process"}
{"concept_id": "C1158199", "aliases": ["reduced flavin adenine dinucleotide metabolic process", "FADH2 metabolism"], "types": ["T044"], "canonical_name": "FADH2 metabolic process", "definition": "The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide. [GOC:ai]"}
{"concept_id": "C1158200", "aliases": ["pyridine nucleotide metabolism"], "types": ["T044"], "canonical_name": "pyridine nucleotide metabolic process", "definition": "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. [GOC:jl]"}
{"concept_id": "C1158201", "aliases": ["nicotinamide metabolism"], "types": ["T044"], "canonical_name": "nicotinamide metabolic process", "definition": "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms. [ISBN:0198506732]"}
{"concept_id": "C1158202", "aliases": ["reduced nicotinamide adenine dinucleotide metabolic process", "NADH metabolism", "reduced NAD metabolism", "reduced nicotinamide adenine dinucleotide metabolism", "NAD (reduced) metabolic process", "reduced NAD metabolic process", "NAD (reduced) metabolism"], "types": ["T044"], "canonical_name": "NADH metabolic process", "definition": "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. [GOC:jl, ISBN:0618254153]"}
{"concept_id": "C1158203", "aliases": ["reduced NAD dehydrogenation", "NADH dehydrogenation", "reduced nicotinamide adenine dinucleotide oxidation", "NAD (reduced) dehydrogenation", "reduced nicotinamide adenine dinucleotide dehydrogenation", "NAD (reduced) oxidation", "reduced NAD oxidation"], "types": ["T044"], "canonical_name": "NADH oxidation", "definition": "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD. [GOC:ai]"}
{"concept_id": "C1158204", "aliases": ["reduced NAD regeneration", "reduced nicotinamide adenine dinucleotide regeneration", "NAD (reduced) regeneration"], "types": ["T044"], "canonical_name": "NADH regeneration", "definition": "A metabolic process that generates a pool of NADH by the reduction of NAD+. [GOC:mah]"}
{"concept_id": "C1158205", "aliases": ["NADP (reduced) metabolic process", "oxidized NADP metabolic process", "nicotinamide adenine dinucleotide phosphate metabolic process", "reduced nicotinamide adenine dinucleotide phosphate metabolic process", "reduced NADP metabolic process", "oxidized nicotinamide adenine dinucleotide phosphate metabolic process", "reduced nicotinamide adenine dinucleotide phosphate metabolism", "oxidized nicotinamide adenine dinucleotide phosphate metabolism", "NADPH metabolic process", "nicotinamide adenine dinucleotide phosphate metabolism", "NADP metabolism", "NADP (oxidized) metabolism", "NADP (reduced) metabolism", "reduced NADP metabolism", "NADP (oxidized) metabolic process", "oxidized NADP metabolism", "NADPH metabolism"], "types": ["T044"], "canonical_name": "NADP metabolic process", "definition": "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. [GOC:mah]"}
{"concept_id": "C1158206", "aliases": ["reduced nicotinamide adenine dinucleotide phosphate regeneration", "NADP (reduced) regeneration", "reduced NADP regeneration"], "types": ["T044"], "canonical_name": "NADPH regeneration", "definition": "A metabolic process that generates a pool of NADPH by the reduction of NADP+. [GOC:mah]"}
{"concept_id": "C1158208", "aliases": ["NAD (oxidized) metabolism", "NAD metabolism", "nicotinamide adenine dinucleotide metabolism", "oxidized NAD metabolic process", "NAD (oxidized) metabolic process", "oxidized nicotinamide adenine dinucleotide metabolic process", "nicotinamide adenine dinucleotide metabolic process", "oxidized NAD metabolism", "oxidized nicotinamide adenine dinucleotide metabolism"], "types": ["T044"], "canonical_name": "NAD metabolic process", "definition": "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. [GOC:jl, ISBN:0618254153]"}
{"concept_id": "C1158209", "aliases": ["NAD phosphorylation and dephosphorylation"], "types": ["T044"], "canonical_name": "NAD phosphorylation and dephosphorylation", "definition": "OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. [GOC:jl, ISBN:0618254153]"}
{"concept_id": "C1158210", "aliases": ["nicotinamide nucleotide metabolism"], "types": ["T044"], "canonical_name": "nicotinamide nucleotide metabolic process", "definition": "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. [ISBN:0198506732]"}
{"concept_id": "C1158211", "aliases": ["N-ribosylnicotinamide metabolic process", "nicotinamide riboside metabolism"], "types": ["T044"], "canonical_name": "nicotinamide riboside metabolic process", "definition": "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. [ISBN:0198506732]"}
{"concept_id": "C1158212", "aliases": ["nicotinate nucleotide metabolism"], "types": ["T044"], "canonical_name": "nicotinate nucleotide metabolic process", "definition": "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin). [ISBN:0198506732]"}
{"concept_id": "C1158213", "aliases": ["pyridine nucleotide cycling"], "types": ["T044"], "canonical_name": "pyridine nucleotide salvage", "definition": "Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1158214", "aliases": ["coenzyme Q metabolism", "ubiquinone metabolism", "coenzyme Q metabolic process"], "types": ["T044"], "canonical_name": "ubiquinone metabolic process", "definition": "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. [GOC:mah]"}
{"concept_id": "C1158215", "aliases": ["pyridoxine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. [GOC:curators]", "canonical_name": "pyridoxine metabolic process"}
{"concept_id": "C1158216", "aliases": ["pyridoxal 5' phosphate salvage"], "types": ["T044"], "canonical_name": "pyridoxal 5'-phosphate salvage", "definition": "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1158217", "aliases": ["quinone cofactor metabolic process"], "types": ["T044"], "canonical_name": "quinone cofactor metabolism"}
{"concept_id": "C1158218", "aliases": ["vitamin K metabolism"], "types": ["T044"], "canonical_name": "vitamin K metabolic process", "definition": "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]"}
{"concept_id": "C1158219", "aliases": ["phytonadione metabolism", "vitamin K1 metabolism", "phytylmenaquinone metabolism", "vitamin K1 metabolic process", "phytylmenaquinone metabolic process", "phylloquinone metabolism", "phytonadione metabolic process", "phytomenadione metabolism", "phytomenadione metabolic process"], "types": ["T044"], "canonical_name": "phylloquinone metabolic process", "definition": "The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]"}
{"concept_id": "C1158220", "aliases": ["menaquinone metabolism", "menatetrenone metabolism", "vitamin K2 metabolism", "menatetrenone metabolic process", "multiprenylmenaquinone metabolic process", "multiprenylmenaquinone metabolism", "vitamin K2 metabolic process"], "types": ["T044"], "canonical_name": "menaquinone metabolic process", "definition": "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]"}
{"concept_id": "C1158221", "aliases": ["thiamin diphosphate metabolism", "thiamine diphosphate metabolism", "thiamin pyrophosphate metabolism", "thiamine pyrophosphate metabolic process", "thiamin diphosphate metabolic process", "TPP metabolic process", "TPP metabolism", "thiamin pyrophosphate metabolic process", "thiamine pyrophosphate metabolism"], "types": ["T044"], "canonical_name": "thiamine diphosphate metabolic process", "definition": "The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1158222", "aliases": ["TPP dephosphorylation", "thiamin diphosphate dephosphorylation"], "types": ["T044"], "canonical_name": "thiamine diphosphate dephosphorylation", "definition": "The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1158223", "aliases": ["corrin metabolism"], "types": ["T044"], "canonical_name": "corrin metabolic process", "definition": "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1158224", "aliases": ["chlorophyll metabolism"], "types": ["T044"], "canonical_name": "chlorophyll metabolic process", "definition": "The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. [GOC:jl]"}
{"concept_id": "C1158225", "aliases": ["bacteriochlorophyll metabolism"], "types": ["T044"], "canonical_name": "bacteriochlorophyll metabolic process", "definition": "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1158226", "aliases": ["haem metabolism", "haem metabolic process", "heme metabolism"], "types": ["T044"], "canonical_name": "heme metabolic process", "definition": "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:jl, ISBN:0124325653]"}
{"concept_id": "C1158227", "aliases": ["heme a metabolism", "haem a metabolism", "haem a metabolic process"], "types": ["T044"], "canonical_name": "heme a metabolic process", "definition": "The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3. [GOC:curators]"}
{"concept_id": "C1158228", "aliases": ["haem B metabolic process", "haem B metabolism", "protoheme metabolism", "protoheme metabolic process", "heme B metabolism"], "types": ["T044"], "canonical_name": "heme B metabolic process", "definition": "The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. [GOC:yaf, PMID:29414780]"}
{"concept_id": "C1158229", "aliases": ["haem C metabolic process", "haem C metabolism", "heme C metabolism"], "types": ["T044"], "canonical_name": "heme C metabolic process", "definition": "The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f. [GOC:curators]"}
{"concept_id": "C1158230", "aliases": ["sirohaem metabolic process", "siroheme metabolism", "sirohaem metabolism"], "types": ["T044"], "canonical_name": "siroheme metabolic process", "definition": "The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. [ISBN:0198506732]"}
{"concept_id": "C1158231", "aliases": ["protoporphyrinogen IX metabolism"], "types": ["T044"], "canonical_name": "protoporphyrinogen IX metabolic process", "definition": "The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation. [ISBN:0198506732]"}
{"concept_id": "C1158232", "aliases": ["uroporphyrinogen III metabolism"], "types": ["T044"], "canonical_name": "uroporphyrinogen III metabolic process", "definition": "The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds. [GOC:ai]"}
{"concept_id": "C1158233", "aliases": ["cobalamin metabolism", "vitamin B12 metabolic process", "vitamin B12 metabolism"], "types": ["T044"], "canonical_name": "cobalamin metabolic process", "definition": "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. [GOC:go_curators]"}
{"concept_id": "C1158238", "aliases": ["siderophore metabolism"], "types": ["T044"], "canonical_name": "siderophore metabolic process", "definition": "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. [ISBN:0198547684]"}
{"concept_id": "C1158239", "aliases": ["rhizobactin 1021 metabolism"], "types": ["T044"], "canonical_name": "rhizobactin 1021 metabolic process", "definition": "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti. [MetaCyc:PWY-761, PMID:11274118]"}
{"concept_id": "C1158240", "aliases": ["vibriobactin metabolism"], "types": ["T044"], "canonical_name": "vibriobactin metabolic process", "definition": "The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae. [GOC:jl, PMID:11112537]"}
{"concept_id": "C1158241", "aliases": ["tetrahydrocorphin metabolism"], "types": ["T044"], "canonical_name": "tetrahydrocorphin metabolic process", "definition": "The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins. [Wikipedia:Morphine]"}
{"concept_id": "C1158242", "aliases": ["nickel-tetrapyrrole coenzyme metabolism"], "types": ["T044"], "canonical_name": "nickel-tetrapyrrole coenzyme metabolic process", "definition": "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase. [GOC:mah, Wikipedia:Cofactor_F430]"}
{"concept_id": "C1158243", "aliases": ["peptidyl-1-thioglycine anabolism from peptidyl-glycine", "peptidyl-1-thioglycine synthesis from peptidyl-glycine", "peptidyl-1-thioglycine formation from peptidyl-glycine"], "types": ["T044"], "canonical_name": "peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine", "definition": "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine. [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]"}
{"concept_id": "C1158244", "aliases": ["peptidyl-1-thioglycine anabolism, carboxy-terminal", "peptidyl-1-thioglycine formation, carboxy-terminal", "peptidyl-1-thioglycine synthesis, carboxy-terminal"], "types": ["T044"], "canonical_name": "peptidyl-1-thioglycine biosynthetic process, carboxy-terminal", "definition": "The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond. [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]"}
{"concept_id": "C1158245", "aliases": ["peptidyl-1-thioglycine synthesis, internal", "peptidyl-1-thioglycine formation, internal", "peptidyl-1-thioglycine anabolism, internal"], "types": ["T044"], "canonical_name": "peptidyl-1-thioglycine biosynthetic process, internal", "definition": "The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide. [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]"}
{"concept_id": "C1158251", "aliases": ["dihydrolipoamide reduction"], "types": ["T044"], "canonical_name": "dihydrolipoamide reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1158252", "aliases": ["dihydrolipoylprotein reduction"], "types": ["T044"], "canonical_name": "dihydrolipoylprotein reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1158253", "aliases": ["ferredoxin metabolism"], "types": ["T044"], "canonical_name": "ferredoxin metabolic process", "definition": "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each. [ISBN:0198506732]"}
{"concept_id": "C1158254", "aliases": [], "types": ["T044"], "canonical_name": "glycerophosphate shuttle", "definition": "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle. [GOC:jl, GOC:mtg_electron_transport, ISBN:0716720094, PMID:16368075]"}
{"concept_id": "C1158255", "aliases": [], "types": ["T044"], "canonical_name": "NADH-O2 electron transport"}
{"concept_id": "C1158256", "aliases": ["oxidative phosphorylation, NADH to ubiquinone"], "types": ["T044"], "canonical_name": "mitochondrial electron transport, NADH to ubiquinone", "definition": "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. [ISBN:0716731363]"}
{"concept_id": "C1158258", "aliases": ["oxidative phosphorylation, succinate to ubiquinone", "mitochondrial electron transport, succinate to coenzyme Q"], "types": ["T044"], "canonical_name": "mitochondrial electron transport, succinate to ubiquinone", "definition": "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II. [ISBN:0716731363]"}
{"concept_id": "C1158260", "aliases": ["oxidized glutathione reduction"], "types": ["T044"], "canonical_name": "oxidized glutathione reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1158261", "aliases": ["electron carrier, chlorophyll electron transport system"], "types": ["T044"], "definition": "A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. [GOC:mtg_electron_transport, ISBN:0198547684]", "canonical_name": "photosynthetic electron transport chain"}
{"concept_id": "C1158262", "aliases": [], "types": ["T044"], "canonical_name": "photosynthetic electron transport in cytochrome b6/f"}
{"concept_id": "C1158263", "aliases": [], "types": ["T044"], "canonical_name": "photosynthetic electron transport in photosystem I", "definition": "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP. [GOC:jid, ISBN:0716731363, ISBN:0816017360]"}
{"concept_id": "C1158264", "aliases": [], "types": ["T044"], "canonical_name": "photosynthetic electron transport in photosystem II", "definition": "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. [GOC:jid, ISBN:0716731363, ISBN:0816017360]"}
{"concept_id": "C1158265", "aliases": [], "types": ["T044"], "canonical_name": "photosynthetic electron transport in plastocyanin"}
{"concept_id": "C1158266", "aliases": [], "types": ["T044"], "canonical_name": "photosynthetic electron transport in plastoquinone"}
{"concept_id": "C1158267", "aliases": [], "types": ["T044"], "canonical_name": "protein-disulfide reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1158268", "aliases": [], "types": ["T044"], "canonical_name": "succinate-O2 electron transport"}
{"concept_id": "C1158270", "aliases": [], "types": ["T044"], "canonical_name": "ubiquinone-8-O2 electron transport"}
{"concept_id": "C1158271", "aliases": ["intermediary metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. [GOC:jl]", "canonical_name": "generation of precursor metabolites and energy"}
{"concept_id": "C1158272", "aliases": ["chemoorganotrophy"], "types": ["T044"], "canonical_name": "energy derivation by oxidation of organic compounds", "definition": "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. [GOC:mah]"}
{"concept_id": "C1158275", "aliases": [], "types": ["T044"], "canonical_name": "aerobic respiration, using carbon monoxide as electron donor", "definition": "The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation. [PMID:18024677]"}
{"concept_id": "C1158276", "aliases": [], "types": ["T044"], "canonical_name": "aerobic respiration, using ferrous ions as electron donor", "definition": "The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide. [ISBN:3131084111]"}
{"concept_id": "C1158277", "aliases": [], "types": ["T044"], "canonical_name": "aerobic respiration, using hydrogen as electron donor", "definition": "The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water. [MetaCyc:P283-PWY]"}
{"concept_id": "C1158278", "aliases": [], "types": ["T044"], "canonical_name": "nitrite oxidation"}
{"concept_id": "C1158279", "aliases": ["aerobic respiration, using sulphur or sulphate as electron donor"], "types": ["T044"], "canonical_name": "aerobic respiration, using sulfur or sulfate as electron donor", "definition": "An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized. [PMID:11425697]"}
{"concept_id": "C1158280", "aliases": [], "types": ["T044"], "definition": "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590]", "canonical_name": "anaerobic respiration"}
{"concept_id": "C1158281", "aliases": [], "types": ["T044"], "canonical_name": "anaerobic ammonium oxidation"}
{"concept_id": "C1158282", "aliases": ["energy reserve metabolism"], "types": ["T044"], "canonical_name": "energy reserve metabolic process", "definition": "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. [GOC:mah]"}
{"concept_id": "C1158283", "aliases": [], "types": ["T044"], "canonical_name": "acetate fermentation", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP. [GOC:jl, MetaCyc:P142-PWY]"}
{"concept_id": "C1158284", "aliases": [], "types": ["T044"], "canonical_name": "homoacetate catabolic process"}
{"concept_id": "C1158285", "aliases": ["amino acid fermentation"], "types": ["T044"], "canonical_name": "anaerobic amino acid catabolic process", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP. [GOC:curators, GOC:jl, MetaCyc:Fermentation]"}
{"concept_id": "C1158286", "aliases": ["cofermentation of pairs of amino acids"], "types": ["T044"], "canonical_name": "anaerobic catabolism of pairs of amino acids", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP. [GOC:mah, PMID:13140081]"}
{"concept_id": "C1158287", "aliases": ["glucose fermentation to butyrate", "butyrate fermentation"], "types": ["T044"], "canonical_name": "glucose catabolic process to butyrate", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum. [ISBN:0198506732]"}
{"concept_id": "C1158288", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic fermentation", "definition": "Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. [GOC:curators]"}
{"concept_id": "C1158289", "aliases": ["glucose catabolic process to butanediol", "butanediol fermentation", "glucose fermentation to butanediol"], "types": ["T044"], "canonical_name": "glycolytic fermentation to butanediol", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into butanediol; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia. [GOC:dph, GOC:nr, ISBN:0198506732]"}
{"concept_id": "C1158290", "aliases": ["homolactic fermentation", "homofermentation", "glucose fermentation to lactate via pyruvate", "homofermentative pathway", "homofermentative lactate fermentation", "homolactate fermentation"], "types": ["T044"], "canonical_name": "glucose catabolic process to lactate via pyruvate", "definition": "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP). [GOC:jl]"}
{"concept_id": "C1158291", "aliases": ["glucose fermentation to mixed acids"], "types": ["T044"], "canonical_name": "mixed acid fermentation", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP. [ISBN:0716720094, MetaCyc:FERMENTATION-PWY]"}
{"concept_id": "C1158292", "aliases": ["acrylate pathway", "nonrandomizing pathway", "propionate fermentation"], "types": ["T044"], "canonical_name": "lactate fermentation to propionate and acetate", "definition": "The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP). [GOC:jl, MetaCyc:PROPFERM-PWY]"}
{"concept_id": "C1158293", "aliases": ["lactate fermentation", "glucose fermentation to lactate"], "types": ["T044"], "canonical_name": "glucose catabolic process to lactate", "definition": "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP). [GOC:jl]"}
{"concept_id": "C1158294", "aliases": ["glucose fermentation to D-lactate and ethanol", "heterofermentation", "heterolactate fermentation", "heterolactic fermentation", "heterofermentative lactate fermentation", "heterofermentative pathway"], "types": ["T044"], "canonical_name": "glucose catabolic process to D-lactate and ethanol", "definition": "The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule. [GOC:jl, MetaCyc:P122-PWY]"}
{"concept_id": "C1158295", "aliases": ["nitrogenous compound catabolic process"], "types": ["T044"], "canonical_name": "nitrogenous compound fermentation", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP. [GOC:mah]"}
{"concept_id": "C1158296", "aliases": [], "types": ["T044"], "canonical_name": "non-glycolytic fermentation", "definition": "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. [GOC:jl, MetaCyc:Fermentation]"}
{"concept_id": "C1158297", "aliases": ["diacetyl fermentation", "citrate fermentation to diacetyl"], "types": ["T044"], "canonical_name": "citrate catabolic process to diacetyl", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP. [MetaCyc:P126-PWY]"}
{"concept_id": "C1158298", "aliases": [], "types": ["T044"], "canonical_name": "ethanol-acetate fermentation to butyrate and caproate", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP. [MetaCyc:P127-PWY]"}
{"concept_id": "C1158299", "aliases": ["glucose catabolic process to lactate and acetate", "bifidum pathway"], "types": ["T044"], "canonical_name": "glucose fermentation to lactate and acetate", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP. [MetaCyc:P124-PWY]"}
{"concept_id": "C1158301", "aliases": ["oxidation of galena", "oxidation of lead sulfide", "lead sulphide oxidation"], "types": ["T044"], "canonical_name": "lead sulfide oxidation", "definition": "The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate. [MetaCyc:P301-PWY]"}
{"concept_id": "C1158302", "aliases": [], "types": ["T044"], "definition": "The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. [http://www.arabidopsis.org]", "canonical_name": "photosynthesis, light reaction"}
{"concept_id": "C1158303", "aliases": [], "types": ["T044"], "canonical_name": "photosynthesis, light harvesting", "definition": "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. [GOC:sm]"}
{"concept_id": "C1158304", "aliases": [], "types": ["T044"], "canonical_name": "photosynthesis, light harvesting in photosystem I", "definition": "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center. [GOC:jid, ISBN:0716731363, ISBN:0816017360]"}
{"concept_id": "C1158305", "aliases": [], "types": ["T044"], "canonical_name": "photosynthesis, light harvesting in photosystem II", "definition": "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center. [GOC:jid, ISBN:0716731363, ISBN:0816017360]"}
{"concept_id": "C1158307", "aliases": [], "types": ["T044"], "canonical_name": "cyclic photosynthetic phosphorylation", "definition": "A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I. [ISBN:0198547684]"}
{"concept_id": "C1158308", "aliases": [], "types": ["T044"], "canonical_name": "noncyclic photosynthetic phosphorylation", "definition": "A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II. [ISBN:0198547684]"}
{"concept_id": "C1158313", "aliases": [], "types": ["T043"], "canonical_name": "regulation of photosynthesis, light reaction", "definition": "Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis. [GOC:jl]"}
{"concept_id": "C1158314", "aliases": [], "types": ["T043"], "canonical_name": "photosystem I stabilization", "definition": "The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. [GOC:go_curators]"}
{"concept_id": "C1158315", "aliases": [], "types": ["T043"], "canonical_name": "photosystem II stabilization", "definition": "The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. [GOC:go_curators]"}
{"concept_id": "C1158318", "aliases": ["glycerol ether metabolism"], "types": ["T044"], "canonical_name": "glycerol ether metabolic process", "definition": "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1158319", "aliases": ["glyceride metabolism", "glyceride metabolic process", "acylglycerol metabolism"], "types": ["T044"], "canonical_name": "acylglycerol metabolic process", "definition": "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. [ISBN:0198506732]"}
{"concept_id": "C1158320", "aliases": ["diacylglycerol metabolism", "diglyceride metabolism"], "types": ["T044"], "canonical_name": "diacylglycerol metabolic process", "definition": "The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [PMID:11481335]"}
{"concept_id": "C1158321", "aliases": ["CDP-diacylglycerol metabolism"], "types": ["T044"], "canonical_name": "CDP-diacylglycerol metabolic process", "definition": "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. [PMID:24533860]"}
{"concept_id": "C1158322", "aliases": ["monoacylglycerol metabolism", "monoglyceride metabolic process", "monoglyceride metabolism"], "types": ["T044"], "canonical_name": "monoacylglycerol metabolic process", "definition": "The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [ISBN:0198506732]"}
{"concept_id": "C1158323", "aliases": ["triacylglycerol metabolism", "triacylglycerol metabolic process", "triglyceride metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. [ISBN:0198506732]", "canonical_name": "triglyceride metabolic process"}
{"concept_id": "C1158324", "aliases": ["triacylglycerol mobilization"], "types": ["T044"], "canonical_name": "triglyceride mobilization", "definition": "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism. [GOC:mah, PMID:11943743, PMID:15713625]"}
{"concept_id": "C1158325", "aliases": ["ether lipid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. [ISBN:0198506732, PMID:15337120]", "canonical_name": "ether lipid metabolic process"}
{"concept_id": "C1158326", "aliases": ["heterocycle metabolism"], "types": ["T044"], "canonical_name": "heterocycle metabolic process", "definition": "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). [ISBN:0198506732]"}
{"concept_id": "C1158327", "aliases": ["vitamin B7 metabolism", "biotin metabolism", "vitamin B7 metabolic process", "vitamin H metabolism", "vitamin H metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. [ISBN:0198506732]", "canonical_name": "biotin metabolic process"}
{"concept_id": "C1158328", "aliases": ["oxazole or thiazole metabolism"], "types": ["T044"], "canonical_name": "oxazole or thiazole metabolic process", "definition": "The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position. [GOC:curators]"}
{"concept_id": "C1158329", "aliases": ["urate metabolism"], "types": ["T044"], "canonical_name": "urate metabolic process", "definition": "The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. [ISBN:0198506732]"}
{"concept_id": "C1158330", "aliases": ["androgen metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]", "canonical_name": "androgen metabolism"}
{"concept_id": "C1158331", "aliases": ["auxin metabolism"], "types": ["T044"], "canonical_name": "auxin metabolic process", "definition": "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth. [GOC:lr]"}
{"concept_id": "C1158332", "aliases": ["C21-steroid hormone metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. [GOC:ai]", "canonical_name": "C21-steroid hormone metabolism"}
{"concept_id": "C1158333", "aliases": ["progesterone metabolism"], "types": ["T044"], "canonical_name": "progesterone metabolic process", "definition": "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/]"}
{"concept_id": "C1158334", "aliases": ["ecdysteroid metabolism"], "types": ["T044"], "canonical_name": "ecdysteroid metabolic process", "definition": "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females. [ISBN:0198506732]"}
{"concept_id": "C1158335", "aliases": [], "types": ["T043"], "canonical_name": "ecdysteroid secretion", "definition": "The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. [GOC:go_curators]"}
{"concept_id": "C1158336", "aliases": [], "types": ["T042"], "canonical_name": "regulation of ecdysteroid secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell. [GOC:go_curators]"}
{"concept_id": "C1158337", "aliases": ["down regulation of ecdysteroid secretion", "downregulation of ecdysteroid secretion", "down-regulation of ecdysteroid secretion"], "types": ["T043"], "canonical_name": "negative regulation of ecdysteroid secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid. [GOC:go_curators]"}
{"concept_id": "C1158338", "aliases": ["up-regulation of ecdysteroid secretion", "upregulation of ecdysteroid secretion", "up regulation of ecdysteroid secretion"], "types": ["T043"], "canonical_name": "positive regulation of ecdysteroid secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid. [GOC:go_curators]"}
{"concept_id": "C1158339", "aliases": ["regulation of ecdysteroid metabolism"], "types": ["T040"], "canonical_name": "regulation of ecdysteroid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females. [ISBN:0198506732]"}
{"concept_id": "C1158340", "aliases": ["down-regulation of ecdysteroid metabolic process", "down regulation of ecdysteroid metabolic process", "negative regulation of ecdysteroid metabolism", "downregulation of ecdysteroid metabolic process"], "types": ["T040"], "canonical_name": "negative regulation of ecdysteroid metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids. [GOC:go_curators]"}
{"concept_id": "C1158341", "aliases": ["up-regulation of ecdysteroid metabolic process", "upregulation of ecdysteroid metabolic process", "up regulation of ecdysteroid metabolic process", "positive regulation of ecdysteroid metabolism"], "types": ["T043"], "canonical_name": "positive regulation of ecdysteroid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids. [GOC:go_curators]"}
{"concept_id": "C1158342", "aliases": ["oestrogen metabolism", "estrogen metabolic process", "oestrogen metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]", "canonical_name": "estrogen metabolism"}
{"concept_id": "C1158343", "aliases": ["glucocorticosteroid metabolism", "glucocorticosteroid metabolic process", "glucocorticoid metabolism"], "types": ["T044"], "canonical_name": "glucocorticoid metabolic process", "definition": "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [ISBN:0198506732]"}
{"concept_id": "C1158344", "aliases": ["juvenile hormone metabolism"], "types": ["T044"], "canonical_name": "juvenile hormone metabolic process", "definition": "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. [GOC:go_curators, ISBN:0198547684]"}
{"concept_id": "C1158345", "aliases": [], "types": ["T040"], "canonical_name": "juvenile hormone secretion", "definition": "The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. [GOC:go_curators, ISBN:0198547684]"}
{"concept_id": "C1158346", "aliases": [], "types": ["T042"], "canonical_name": "regulation of juvenile hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of juvenile hormone secretion. [GOC:go_curators]"}
{"concept_id": "C1158347", "aliases": ["down-regulation of juvenile hormone secretion", "downregulation of juvenile hormone secretion", "down regulation of juvenile hormone secretion"], "types": ["T043"], "canonical_name": "negative regulation of juvenile hormone secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1158348", "aliases": ["up-regulation of juvenile hormone secretion", "up regulation of juvenile hormone secretion", "upregulation of juvenile hormone secretion"], "types": ["T043"], "canonical_name": "positive regulation of juvenile hormone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1158349", "aliases": ["regulation of juvenile hormone metabolism"], "types": ["T042"], "canonical_name": "regulation of juvenile hormone metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1158350", "aliases": ["down-regulation of juvenile hormone metabolic process", "down regulation of juvenile hormone metabolic process", "downregulation of juvenile hormone metabolic process", "negative regulation of juvenile hormone metabolism"], "types": ["T043"], "canonical_name": "negative regulation of juvenile hormone metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1158351", "aliases": ["upregulation of juvenile hormone metabolic process", "up-regulation of juvenile hormone metabolic process", "up regulation of juvenile hormone metabolic process", "positive regulation of juvenile hormone metabolism"], "types": ["T043"], "canonical_name": "positive regulation of juvenile hormone metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. [GOC:go_curators]"}
{"concept_id": "C1158352", "aliases": ["mineralocorticoid metabolism"], "types": ["T044"], "canonical_name": "mineralocorticoid metabolic process", "definition": "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance. [ISBN:0198506732]"}
{"concept_id": "C1158353", "aliases": [], "types": ["T044"], "canonical_name": "peptide hormone processing", "definition": "The generation of a mature peptide hormone by posttranslational processing of a prohormone. [GOC:mah]"}
{"concept_id": "C1158354", "aliases": [], "types": ["T044"], "canonical_name": "insulin processing", "definition": "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges. [ISBN:0198506732]"}
{"concept_id": "C1158355", "aliases": ["isopentenyl diphosphate metabolic process", "isopentenyl pyrophosphate metabolism", "IPP metabolism", "isopentenyl pyrophosphate metabolic process", "isopentenyl diphosphate metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids. [ISBN:0198506732]", "canonical_name": "IPP metabolic process"}
{"concept_id": "C1158356", "aliases": ["ketone metabolism"], "types": ["T044"], "canonical_name": "cellular ketone metabolic process", "definition": "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. [GOC:jl, ISBN:0787650153]"}
{"concept_id": "C1158357", "aliases": ["camphor metabolic process", "(+)-camphor metabolism", "camphor metabolism"], "types": ["T044"], "canonical_name": "(+)-camphor metabolic process", "definition": "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed. [UM-BBD_pathwayID:cam]"}
{"concept_id": "C1158358", "aliases": ["2-oxobutyrate metabolism", "alpha-ketobutyrate metabolism", "alpha-ketobutyrate metabolic process"], "types": ["T044"], "canonical_name": "2-oxobutyrate metabolic process", "definition": "The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. [PMID:17034760]"}
{"concept_id": "C1158359", "aliases": ["acetoin metabolism"], "types": ["T044"], "canonical_name": "acetoin metabolic process", "definition": "The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source. [GOC:mlg]"}
{"concept_id": "C1158360", "aliases": ["arachidonic acid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732]", "canonical_name": "arachidonic acid metabolic process"}
{"concept_id": "C1158361", "aliases": [], "types": ["T044"], "canonical_name": "epoxygenase P450 pathway", "definition": "The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. [GOC:mah, PMID:17979511]"}
{"concept_id": "C1158362", "aliases": ["leukotriene metabolism"], "types": ["T044"], "canonical_name": "leukotriene metabolic process", "definition": "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:ma]"}
{"concept_id": "C1158363", "aliases": ["prostanoid metabolism"], "types": ["T044"], "canonical_name": "prostanoid metabolic process", "definition": "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. [ISBN:0198506732]"}
{"concept_id": "C1158364", "aliases": ["prostaglandin metabolism"], "types": ["T044"], "canonical_name": "prostaglandin metabolic process", "definition": "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [ISBN:0198506732]"}
{"concept_id": "C1158365", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid desaturation"}
{"concept_id": "C1158366", "aliases": [], "types": ["T044"], "definition": "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. [ISBN:0198506732, MetaCyc:FAO-PWY]", "canonical_name": "fatty acid oxidation"}
{"concept_id": "C1158367", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid alpha-oxidation", "definition": "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway. [PMID:10198260]"}
{"concept_id": "C1158368", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid beta-oxidation", "definition": "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]"}
{"concept_id": "C1158369", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fatty acid oxidation", "definition": "Any process that modulates the frequency, rate or extent of fatty acid oxidation. [GOC:ai]"}
{"concept_id": "C1158370", "aliases": ["down-regulation of fatty acid oxidation", "downregulation of fatty acid oxidation", "down regulation of fatty acid oxidation"], "types": ["T043"], "canonical_name": "negative regulation of fatty acid oxidation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation. [GOC:ai]"}
{"concept_id": "C1158371", "aliases": ["up-regulation of fatty acid oxidation", "upregulation of fatty acid oxidation", "up regulation of fatty acid oxidation"], "types": ["T043"], "canonical_name": "positive regulation of fatty acid oxidation", "definition": "Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. [GOC:ai]"}
{"concept_id": "C1158372", "aliases": ["jasmonic acid metabolism"], "types": ["T044"], "canonical_name": "jasmonic acid metabolic process", "definition": "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid. [ISBN:0387969845]"}
{"concept_id": "C1158373", "aliases": ["long-chain fatty acid metabolism"], "types": ["T044"], "canonical_name": "long-chain fatty acid metabolic process", "definition": "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [GOC:ajp]"}
{"concept_id": "C1158374", "aliases": ["regulation of fatty acid metabolism"], "types": ["T043"], "canonical_name": "regulation of fatty acid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. [GOC:go_curators]"}
{"concept_id": "C1158375", "aliases": ["negative regulation of fatty acid metabolism", "down regulation of fatty acid metabolic process", "down-regulation of fatty acid metabolic process", "downregulation of fatty acid metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of fatty acid metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. [GOC:go_curators]"}
{"concept_id": "C1158376", "aliases": ["up-regulation of fatty acid metabolic process", "positive regulation of fatty acid metabolism", "upregulation of fatty acid metabolic process", "up regulation of fatty acid metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of fatty acid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. [GOC:go_curators]"}
{"concept_id": "C1158377", "aliases": ["short-chain fatty acid metabolism"], "types": ["T044"], "canonical_name": "short-chain fatty acid metabolic process", "definition": "The chemical reactions and pathways involving fatty acids with a chain length of less than C6. [Wikipedia:Fatty_acid_metabolism]"}
{"concept_id": "C1158378", "aliases": ["very-long-chain fatty acid metabolism", "very long chain fatty acid metabolic process", "very-long-chain fatty acid metabolic process"], "types": ["T044"], "canonical_name": "very long-chain fatty acid metabolic process", "definition": "The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. [GOC:hjd]"}
{"concept_id": "C1158379", "aliases": ["glycerolipid metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. [GOC:ai, PMID:8906569]", "canonical_name": "glycerolipid metabolism"}
{"concept_id": "C1158380", "aliases": ["isoprene metabolic process", "isoprene metabolism", "hemiterpene metabolic process", "hemiterpene metabolism", "2-methyl-1,3-butadiene metabolism", "isoprenoid metabolism", "2-methyl-1,3-butadiene metabolic process"], "types": ["T044"], "canonical_name": "isoprenoid metabolic process", "definition": "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198547684]"}
{"concept_id": "C1158381", "aliases": ["farnesyl diphosphate metabolism"], "types": ["T044"], "canonical_name": "farnesyl diphosphate metabolic process", "definition": "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation. [GOC:go_curators]"}
{"concept_id": "C1158382", "aliases": ["polyterpene metabolism", "polyterpene metabolic process"], "types": ["T044"], "canonical_name": "polyterpene metabolism"}
{"concept_id": "C1158383", "aliases": ["terpenoid metabolism"], "types": ["T044"], "canonical_name": "terpenoid metabolic process", "definition": "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. [ISBN:0198506732]"}
{"concept_id": "C1158384", "aliases": ["diterpenoid metabolism"], "types": ["T044"], "canonical_name": "diterpenoid metabolic process", "definition": "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units. [ISBN:0198547684]"}
{"concept_id": "C1158385", "aliases": ["gibberellin metabolism", "gibberellic acid metabolism", "gibberellic acid metabolic process"], "types": ["T044"], "canonical_name": "gibberellin metabolic process", "definition": "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators. [ISBN:0387969845]"}
{"concept_id": "C1158386", "aliases": ["monoterpenoid metabolism"], "types": ["T044"], "canonical_name": "monoterpenoid metabolic process", "definition": "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton. [ISBN:0198547684]"}
{"concept_id": "C1158387", "aliases": ["polyterpenoid metabolism"], "types": ["T044"], "canonical_name": "polyterpenoid metabolic process", "definition": "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units. [ISBN:0198547684]"}
{"concept_id": "C1158388", "aliases": ["sesquiterpenoid metabolism"], "types": ["T044"], "canonical_name": "sesquiterpenoid metabolic process", "definition": "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units. [ISBN:0198547684]"}
{"concept_id": "C1158389", "aliases": ["abscisic acid metabolism"], "types": ["T044"], "canonical_name": "abscisic acid metabolic process", "definition": "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. [ISBN:0387969845]"}
{"concept_id": "C1158390", "aliases": ["tetraterpenoid metabolism"], "types": ["T044"], "canonical_name": "tetraterpenoid metabolic process", "definition": "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units. [ISBN:0198547684]"}
{"concept_id": "C1158391", "aliases": ["carotenoid metabolism"], "types": ["T044"], "canonical_name": "carotenoid metabolic process", "definition": "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. [ISBN:0198547684]"}
{"concept_id": "C1158392", "aliases": ["carotene metabolism"], "types": ["T044"], "canonical_name": "carotene metabolic process", "definition": "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids. [ISBN:0198547684]"}
{"concept_id": "C1158393", "aliases": ["xanthophyll metabolism"], "types": ["T044"], "canonical_name": "xanthophyll metabolic process", "definition": "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids. [ISBN:0198547684]"}
{"concept_id": "C1158394", "aliases": ["triterpenoid metabolism"], "types": ["T044"], "canonical_name": "triterpenoid metabolic process", "definition": "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units. [ISBN:0198547684]"}
{"concept_id": "C1158395", "aliases": ["pentacyclic triterpenoid metabolism"], "types": ["T044"], "canonical_name": "pentacyclic triterpenoid metabolic process", "definition": "The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. [ISBN:0198506732]"}
{"concept_id": "C1158396", "aliases": ["hopanoid metabolism"], "types": ["T044"], "canonical_name": "hopanoid metabolic process", "definition": "The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. [ISBN:0198547684]"}
{"concept_id": "C1158397", "aliases": ["prenol metabolism"], "types": ["T044"], "canonical_name": "prenol metabolic process", "definition": "The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail. [ISBN:0198547684]"}
{"concept_id": "C1158398", "aliases": ["polyprenol metabolism"], "types": ["T044"], "canonical_name": "polyprenol metabolic process", "definition": "The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. [PMID:11108713]"}
{"concept_id": "C1158399", "aliases": ["dolichol metabolism"], "types": ["T044"], "canonical_name": "dolichol metabolic process", "definition": "The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. [ISBN:0198506732]"}
{"concept_id": "C1158400", "aliases": ["dolichyl diphosphate metabolism"], "types": ["T044"], "canonical_name": "dolichyl diphosphate metabolic process", "definition": "The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes. [ISBN:0198506732]"}
{"concept_id": "C1158401", "aliases": ["regulation of isoprenoid metabolism"], "types": ["T043"], "canonical_name": "regulation of isoprenoid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids. [GOC:go_curators]"}
{"concept_id": "C1158402", "aliases": ["negative regulation of isoprenoid metabolism", "down-regulation of isoprenoid metabolic process", "downregulation of isoprenoid metabolic process", "down regulation of isoprenoid metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of isoprenoid metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid. [GOC:go_curators]"}
{"concept_id": "C1158403", "aliases": ["up-regulation of isoprenoid metabolic process", "upregulation of isoprenoid metabolic process", "up regulation of isoprenoid metabolic process", "positive regulation of isoprenoid metabolism"], "types": ["T043"], "canonical_name": "positive regulation of isoprenoid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid. [GOC:go_curators]"}
{"concept_id": "C1158404", "aliases": ["retinoid metabolism"], "types": ["T044"], "canonical_name": "retinoid metabolic process", "definition": "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. [ISBN:0198506732]"}
{"concept_id": "C1158405", "aliases": ["lipid A metabolism"], "types": ["T044"], "canonical_name": "lipid A metabolic process", "definition": "The chemical reactions and pathways involving lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. [ISBN:0198506732, PMID:20974832, PMID:22216004]"}
{"concept_id": "C1158406", "aliases": [], "types": ["T044"], "canonical_name": "lipid modification", "definition": "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. [GOC:mah]"}
{"concept_id": "C1158407", "aliases": [], "types": ["T044"], "canonical_name": "lipid glycosylation", "definition": "Covalent attachment of a glycosyl residue to a lipid molecule. [GOC:mah]"}
{"concept_id": "C1158408", "aliases": ["membrane lipid metabolism"], "types": ["T044"], "canonical_name": "membrane lipid metabolic process", "definition": "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. [GOC:ai]"}
{"concept_id": "C1158409", "aliases": ["glycolipid metabolism"], "types": ["T044"], "canonical_name": "glycolipid metabolic process", "definition": "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent. [ISBN:0198547684]"}
{"concept_id": "C1158410", "aliases": ["galactolipid metabolism"], "types": ["T044"], "canonical_name": "galactolipid metabolic process", "definition": "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. [ISBN:0198506732]"}
{"concept_id": "C1158411", "aliases": ["galactosylceramide metabolism"], "types": ["T044"], "canonical_name": "galactosylceramide metabolic process", "definition": "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. [GOC:ai]"}
{"concept_id": "C1158412", "aliases": ["glycosphingolipid metabolism"], "types": ["T044"], "canonical_name": "glycosphingolipid metabolic process", "definition": "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. [ISBN:0198547684]"}
{"concept_id": "C1158413", "aliases": ["ganglioside metabolism"], "types": ["T044"], "canonical_name": "ganglioside metabolic process", "definition": "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. [ISBN:0198506732]"}
{"concept_id": "C1158414", "aliases": ["globoside metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes. [ISBN:0198506732]", "canonical_name": "globoside metabolic process"}
{"concept_id": "C1158415", "aliases": ["GSI anchor metabolism"], "types": ["T044"], "canonical_name": "GSI anchor metabolic process", "definition": "The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane. [GOC:go_curators]"}
{"concept_id": "C1158416", "aliases": ["glycosylceramide metabolism"], "types": ["T044"], "canonical_name": "glycosylceramide metabolic process", "definition": "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1158417", "aliases": ["glucosylceramide metabolism"], "types": ["T044"], "canonical_name": "glucosylceramide metabolic process", "definition": "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative. [ISBN:0198506732]"}
{"concept_id": "C1158418", "aliases": ["lactosylceramide metabolism"], "types": ["T044"], "canonical_name": "lactosylceramide metabolic process", "definition": "The chemical reactions and pathways involving lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides. [ISBN:0198506732]"}
{"concept_id": "C1158419", "aliases": ["phospholipid metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]", "canonical_name": "phospholipid metabolism"}
{"concept_id": "C1158420", "aliases": ["glycerophospholipid metabolism", "phosphoglyceride metabolic process", "phosphoglyceride metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. [ISBN:0198506732]", "canonical_name": "glycerophospholipid metabolic process"}
{"concept_id": "C1158421", "aliases": [], "types": ["T044"], "canonical_name": "alpha-glycerophosphate pathway"}
{"concept_id": "C1158422", "aliases": ["phosphatidic acid metabolism"], "types": ["T044"], "canonical_name": "phosphatidic acid metabolic process", "definition": "The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [ISBN:0198506732]"}
{"concept_id": "C1158423", "aliases": ["phosphatidylcholine metabolism"], "types": ["T044"], "canonical_name": "phosphatidylcholine metabolic process", "definition": "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. [ISBN:0198506732]"}
{"concept_id": "C1158425", "aliases": ["phosphatidylglycerol metabolism"], "types": ["T044"], "canonical_name": "phosphatidylglycerol metabolic process", "definition": "The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. [ISBN:0198506732]"}
{"concept_id": "C1158426", "aliases": ["phosphatidylserine metabolism"], "types": ["T044"], "canonical_name": "phosphatidylserine metabolic process", "definition": "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. [ISBN:0198506732]"}
{"concept_id": "C1158428", "aliases": ["glycosylphosphatidylinositol metabolic process", "glycosylphosphatidylinositol metabolism", "GPI anchor metabolism"], "types": ["T044"], "canonical_name": "GPI anchor metabolic process", "definition": "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. [ISBN:0198506732]"}
{"concept_id": "C1158429", "aliases": [], "types": ["T044"], "canonical_name": "GPI anchor release", "definition": "The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane. [GOC:mah, PMID:18811934]"}
{"concept_id": "C1158430", "aliases": ["phosphoinositide metabolic process", "PtdIns metabolic process", "phosphoinositide metabolism", "PtdIns metabolism", "phosphatidylinositol metabolism"], "types": ["T044"], "canonical_name": "phosphatidylinositol metabolic process", "definition": "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]"}
{"concept_id": "C1158431", "aliases": ["inositol phosphorylceramide metabolic process", "inositol phosphorylceramide metabolism", "inositolphosphoceramide metabolism"], "types": ["T044"], "canonical_name": "inositol phosphoceramide metabolic process", "definition": "The chemical reactions and pathways involving inositol phosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group. [PMID:19726565]"}
{"concept_id": "C1158433", "aliases": ["MIPC metabolism", "mannose-inositol-P-ceramide (MIPC) metabolic process", "mannose-inositol-P-ceramide (MIPC) metabolism", "MIPC metabolic process", "mannose inositol phosphoceramide metabolism", "mannose inositol phosphoceramide metabolic process", "mannosyl-inositol-phosphorylceramide metabolism"], "types": ["T044"], "canonical_name": "mannosyl-inositol phosphorylceramide metabolic process", "definition": "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative. [GOC:ai, MetaCyc:MIPC]"}
{"concept_id": "C1158434", "aliases": ["M(IP)2C metabolism", "M(IP)2C metabolic process", "mannosyl diphosphorylinositol ceramide metabolism"], "types": ["T044"], "canonical_name": "mannosyl diphosphorylinositol ceramide metabolic process", "definition": "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative. [GOC:ai]"}
{"concept_id": "C1158435", "aliases": [], "types": ["T044"], "canonical_name": "phospholipid transfer to membrane", "definition": "The transfer of a phospholipid from its site of synthesis to the plasma membrane. [GOC:go_curators]"}
{"concept_id": "C1158436", "aliases": ["PAF metabolism", "PAF metabolic process", "platelet activating factor metabolism"], "types": ["T044"], "canonical_name": "platelet activating factor metabolic process", "definition": "The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. [ISBN:0198547684]"}
{"concept_id": "C1158437", "aliases": ["sphingomyelin metabolism"], "types": ["T044"], "canonical_name": "sphingomyelin metabolic process", "definition": "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. [ISBN:0198506732]"}
{"concept_id": "C1158438", "aliases": ["sphingolipid metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732]", "canonical_name": "sphingolipid metabolism"}
{"concept_id": "C1158439", "aliases": ["sphingoid base metabolic process", "sphingoid base metabolism", "sphingoid metabolism"], "types": ["T044"], "canonical_name": "sphingoid metabolic process", "definition": "The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. [ISBN:0198506732]"}
{"concept_id": "C1158440", "aliases": ["ceramide metabolism"], "types": ["T044"], "canonical_name": "ceramide metabolic process", "definition": "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. [ISBN:0198547684]"}
{"concept_id": "C1158441", "aliases": ["phytosphingosine metabolism"], "types": ["T044"], "canonical_name": "phytosphingosine metabolic process", "definition": "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids. [ISBN:0198506732]"}
{"concept_id": "C1158442", "aliases": ["dihydrosphingosine metabolic process", "dihydrosphingosine metabolism", "sphinganine metabolism"], "types": ["T044"], "canonical_name": "sphinganine metabolic process", "definition": "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol. [PMID:29165427]"}
{"concept_id": "C1158443", "aliases": ["sphinganine-1-phosphate metabolism", "dihydrosphingosine-1-phosphate metabolism", "dihydrosphingosine-1-phosphate metabolic process"], "types": ["T044"], "canonical_name": "sphinganine-1-phosphate metabolic process", "definition": "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. [GOC:ai]"}
{"concept_id": "C1158444", "aliases": ["neutral lipid metabolism"], "types": ["T044"], "canonical_name": "neutral lipid metabolic process", "definition": "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. [ISBN:0198547684]"}
{"concept_id": "C1158445", "aliases": ["regulation of lipid metabolism"], "types": ["T043"], "canonical_name": "regulation of lipid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. [GOC:go_curators]"}
{"concept_id": "C1158446", "aliases": ["negative regulation of lipid metabolism", "down regulation of lipid metabolic process", "down-regulation of lipid metabolic process", "downregulation of lipid metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of lipid metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. [GOC:go_curators]"}
{"concept_id": "C1158447", "aliases": ["positive regulation of lipid metabolism", "up regulation of lipid metabolic process", "up-regulation of lipid metabolic process", "upregulation of lipid metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of lipid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. [GOC:go_curators]"}
{"concept_id": "C1158448", "aliases": [], "types": ["T044"], "canonical_name": "bile acid 7alpha-dehydroxylation pathway"}
{"concept_id": "C1158449", "aliases": ["phytosteroid metabolism"], "types": ["T044"], "canonical_name": "phytosteroid metabolic process", "definition": "The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1158450", "aliases": ["brassinosteroid metabolism"], "types": ["T044"], "canonical_name": "brassinosteroid metabolic process", "definition": "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. [ISBN:0192801023]"}
{"concept_id": "C1158451", "aliases": ["regulation of steroid metabolism"], "types": ["T043"], "canonical_name": "regulation of steroid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. [GOC:go_curators]"}
{"concept_id": "C1158452", "aliases": ["down-regulation of steroid metabolic process", "negative regulation of steroid metabolism", "downregulation of steroid metabolic process", "down regulation of steroid metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of steroid metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. [GOC:go_curators]"}
{"concept_id": "C1158453", "aliases": ["up-regulation of steroid metabolic process", "upregulation of steroid metabolic process", "positive regulation of steroid metabolism", "up regulation of steroid metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of steroid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. [GOC:go_curators]"}
{"concept_id": "C1158454", "aliases": ["sulpholipid metabolic process", "sulfolipid metabolism", "sulpholipid metabolism"], "types": ["T044"], "canonical_name": "sulfolipid metabolic process", "definition": "The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid. [PMID:9751667]"}
{"concept_id": "C1158455", "aliases": ["aldoxime metabolism"], "types": ["T044"], "canonical_name": "aldoxime metabolic process", "definition": "The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH. [GOC:curators]"}
{"concept_id": "C1158456", "aliases": ["alkaloid metabolism"], "types": ["T044"], "canonical_name": "alkaloid metabolic process", "definition": "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). [GOC:lr, ISBN:0122146743]"}
{"concept_id": "C1158457", "aliases": ["dipyrrin metabolism"], "types": ["T044"], "canonical_name": "dipyrrin metabolic process", "definition": "The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group. [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03]"}
{"concept_id": "C1158458", "aliases": ["nicotine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. [GOC:sm, ISBN:0198547684]", "canonical_name": "nicotine metabolic process"}
{"concept_id": "C1158459", "aliases": ["purine alkaloid metabolism"], "types": ["T044"], "canonical_name": "purine alkaloid metabolic process", "definition": "The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure. [GOC:ai]"}
{"concept_id": "C1158460", "aliases": ["terpenoid indole alkaloid metabolism"], "types": ["T044"], "canonical_name": "terpenoid indole alkaloid metabolic process", "definition": "The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate). [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html]"}
{"concept_id": "C1158461", "aliases": ["tropane alkaloid metabolism"], "types": ["T044"], "canonical_name": "tropane alkaloid metabolic process", "definition": "The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1158462", "aliases": [], "types": ["T044"], "canonical_name": "ammonia oxidation", "definition": "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons. [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242]"}
{"concept_id": "C1158463", "aliases": ["cyanate metabolism"], "types": ["T044"], "canonical_name": "cyanate metabolic process", "definition": "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid. [ISBN:0198506732]"}
{"concept_id": "C1158464", "aliases": ["cyanide metabolism"], "types": ["T044"], "canonical_name": "cyanide metabolic process", "definition": "The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain. [ISBN:0198506732]"}
{"concept_id": "C1158465", "aliases": [], "types": ["T044"], "canonical_name": "denitrification pathway", "definition": "The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen. [MetaCyc:DENITRIFICATION-PWY]"}
{"concept_id": "C1158466", "aliases": ["nitrate metabolism"], "types": ["T044"], "canonical_name": "nitrate metabolic process", "definition": "The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. [GOC:jl]"}
{"concept_id": "C1158467", "aliases": ["assimilatory nitrate reduction"], "types": ["T043"], "canonical_name": "nitrate assimilation", "definition": "The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances. [GOC:das, GOC:mah, PMID:10542156, PMID:8122899]"}
{"concept_id": "C1158468", "aliases": ["nitric oxide metabolism"], "types": ["T044"], "canonical_name": "nitric oxide metabolic process", "definition": "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. [GOC:ai]"}
{"concept_id": "C1158469", "aliases": [], "types": ["T044"], "canonical_name": "nitrogen utilization", "definition": "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. [GOC:mah, GOC:mlg]"}
{"concept_id": "C1158470", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nitrogen utilization", "definition": "Any process that modulates the frequency, rate or extent of nitrogen utilization. [GOC:go_curators]"}
{"concept_id": "C1158471", "aliases": ["down regulation of nitrogen utilization", "down-regulation of nitrogen utilization", "downregulation of nitrogen utilization"], "types": ["T043"], "canonical_name": "negative regulation of nitrogen utilization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization. [GOC:go_curators]"}
{"concept_id": "C1158472", "aliases": ["up-regulation of nitrogen utilization", "up regulation of nitrogen utilization", "upregulation of nitrogen utilization"], "types": ["T043"], "canonical_name": "positive regulation of nitrogen utilization", "definition": "Any process that activates or increases the frequency, rate or extent of nitrogen utilization. [GOC:go_curators]"}
{"concept_id": "C1158474", "aliases": ["argininosuccinate metabolism"], "types": ["T044"], "canonical_name": "argininosuccinate metabolic process", "definition": "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate. [ISBN:0198506732]"}
{"concept_id": "C1158475", "aliases": ["urea metabolism"], "types": ["T044"], "canonical_name": "urea metabolic process", "definition": "The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. [ISBN:0198506732]"}
{"concept_id": "C1158476", "aliases": ["nucleobase, nucleoside, nucleotide and nucleic acid metabolism", "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism", "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"], "types": ["T044"], "canonical_name": "nucleobase-containing compound metabolic process", "definition": "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai]"}
{"concept_id": "C1158477", "aliases": ["DNA import into cell"], "types": ["T043"], "canonical_name": "cellular DNA uptake"}
{"concept_id": "C1158478", "aliases": [], "types": ["T045"], "definition": "The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. [GOC:mah]", "canonical_name": "DNA integration"}
{"concept_id": "C1158479", "aliases": [], "types": ["T045"], "definition": "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. [GOC:jl, GOC:ma]", "canonical_name": "DNA modification"}
{"concept_id": "C1158480", "aliases": [], "types": ["T045"], "definition": "The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar. [GOC:ai]", "canonical_name": "depurination"}
{"concept_id": "C1158481", "aliases": [], "types": ["T045"], "canonical_name": "depyrimidination", "definition": "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar. [GOC:ai]"}
{"concept_id": "C1158482", "aliases": [], "types": ["T045"], "canonical_name": "DNA ADP-ribosylation", "definition": "The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA. [PMID:11592983, PMID:27471034, PMID:29361132, PMID:29520010]"}
{"concept_id": "C1158483", "aliases": [], "types": ["T045"], "definition": "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. [ISBN:0716735970]", "canonical_name": "DNA alkylation"}
{"concept_id": "C1158484", "aliases": [], "types": ["T045"], "canonical_name": "DNA deamination", "definition": "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil. [GOC:ai]"}
{"concept_id": "C1158485", "aliases": [], "types": ["T045"], "canonical_name": "DNA restriction-modification system", "definition": "A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. [GOC:jl, UniProtKB-KW:KW-0680]"}
{"concept_id": "C1158486", "aliases": ["DNA condensation", "chromosome organization and biogenesis", "chromosome organization", "chromosome organisation"], "types": ["T045"], "definition": "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]", "canonical_name": "DNA packaging"}
{"concept_id": "C1158487", "aliases": [], "types": ["T043"], "canonical_name": "viral DNA genome packaging", "definition": "The packing of viral DNA into a capsid. [ISBN:0781702534]"}
{"concept_id": "C1158489", "aliases": [], "types": ["T045"], "canonical_name": "intron homing", "definition": "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron. [PMID:10487208]"}
{"concept_id": "C1158490", "aliases": [], "types": ["T045"], "canonical_name": "homing of group II introns", "definition": "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure. [GOC:mcc, ISBN:0716743663, PMID:10487208]"}
{"concept_id": "C1158491", "aliases": [], "types": ["T045"], "canonical_name": "movement of group I intron", "definition": "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction. [GOC:mcc, ISBN:0716743663, PMID:10487208]"}
{"concept_id": "C1158494", "aliases": ["regulation of DNA transposition"], "types": ["T043"], "canonical_name": "regulation of transposition, DNA-mediated", "definition": "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule. [GOC:dph, GOC:krc]"}
{"concept_id": "C1158495", "aliases": ["downregulation of DNA transposition", "down regulation of DNA transposition", "down-regulation of DNA transposition", "negative regulation of DNA transposition"], "types": ["T043"], "canonical_name": "negative regulation of transposition, DNA-mediated", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition. [GOC:dph, GOC:krc, GOC:tb]"}
{"concept_id": "C1158496", "aliases": ["upregulation of DNA transposition", "up-regulation of DNA transposition", "positive regulation of DNA transposition", "up regulation of DNA transposition"], "types": ["T043"], "canonical_name": "positive regulation of transposition, DNA-mediated", "definition": "Any process that activates or increases the frequency, rate or extent of DNA transposition. [GOC:dph, GOC:krc]"}
{"concept_id": "C1158497", "aliases": [], "types": ["T045"], "canonical_name": "Ty element transposition"}
{"concept_id": "C1158498", "aliases": [], "types": ["T045"], "canonical_name": "Ty1 element transposition"}
{"concept_id": "C1158499", "aliases": [], "types": ["T045"], "canonical_name": "Ty2 element transposition"}
{"concept_id": "C1158500", "aliases": [], "types": ["T045"], "canonical_name": "Ty3 element transposition"}
{"concept_id": "C1158501", "aliases": [], "types": ["T045"], "definition": "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles. [GOC:elh]", "canonical_name": "mitotic recombination"}
{"concept_id": "C1158502", "aliases": ["strand invasion involved in gene conversion at mating-type locus"], "types": ["T045"], "canonical_name": "gene conversion at mating-type locus", "definition": "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged. [GOC:elh, PMID:10716938, PMID:7646483, PMID:9928492]"}
{"concept_id": "C1158503", "aliases": ["Rad51 nucleoprotein filament formation"], "types": ["T045"], "canonical_name": "DNA recombinase assembly", "definition": "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA. [PMID:10357855]"}
{"concept_id": "C1158505", "aliases": [], "types": ["T045"], "canonical_name": "heteroduplex formation", "definition": "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. [GOC:elh, PMID:10357855]"}
{"concept_id": "C1158506", "aliases": [], "types": ["T045"], "canonical_name": "removal of nonhomologous ends", "definition": "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. [PMID:10357855]"}
{"concept_id": "C1158507", "aliases": [], "types": ["T045"], "canonical_name": "D-loop formation"}
{"concept_id": "C1158508", "aliases": ["recombination within ribosomal DNA repeats"], "types": ["T045"], "canonical_name": "recombination within rDNA repeats", "definition": "Genetic recombination within the DNA of the genes coding for ribosomal RNA. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158509", "aliases": [], "types": ["T043"], "canonical_name": "regulation of recombination within rDNA repeats", "definition": "OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158510", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of recombination within rDNA repeats", "definition": "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158511", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of recombination within rDNA repeats", "definition": "OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158512", "aliases": [], "types": ["T045"], "definition": "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. [GOC:elh]", "canonical_name": "recombinational repair"}
{"concept_id": "C1158513", "aliases": ["homology-directed repair", "double-strand break repair via homologous recombination", "HRR", "HDR", "Rad51-dependent recombinational repair", "homologous recombinational repair"], "types": ["T045"], "definition": "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. [GOC:elh, PMID:10357855]", "canonical_name": "Rhp51-dependent recombinational repair"}
{"concept_id": "C1158514", "aliases": [], "types": ["T045"], "canonical_name": "double-strand break repair via break-induced replication", "definition": "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. [GOC:elh, PMID:10357855]"}
{"concept_id": "C1158516", "aliases": [], "types": ["T045"], "canonical_name": "DNA repair synthesis"}
{"concept_id": "C1158517", "aliases": [], "types": ["T045"], "canonical_name": "strand displacement", "definition": "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. [PMID:10357855]"}
{"concept_id": "C1158518", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic recombination", "definition": "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. [GOC:go_curators]"}
{"concept_id": "C1158519", "aliases": ["downregulation of mitotic recombination", "down-regulation of mitotic recombination", "down regulation of mitotic recombination"], "types": ["T043"], "canonical_name": "negative regulation of mitotic recombination", "definition": "Any process that inhibits or decreases the rate of DNA recombination during mitosis. [GOC:go_curators, GOC:hjd]"}
{"concept_id": "C1158520", "aliases": ["up regulation of mitotic recombination", "up-regulation of mitotic recombination", "upregulation of mitotic recombination"], "types": ["T043"], "canonical_name": "positive regulation of mitotic recombination", "definition": "Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis. [GOC:go_curators]"}
{"concept_id": "C1158521", "aliases": [], "types": ["T045"], "canonical_name": "plasmid recombination", "definition": "A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules. [GOC:mlg]"}
{"concept_id": "C1158522", "aliases": [], "types": ["T043"], "canonical_name": "regulation of DNA recombination", "definition": "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158523", "aliases": ["down regulation of DNA recombination", "downregulation of DNA recombination", "down-regulation of DNA recombination"], "types": ["T045"], "canonical_name": "negative regulation of DNA recombination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. [GOC:go_curators]"}
{"concept_id": "C1158524", "aliases": ["upregulation of DNA recombination", "up regulation of DNA recombination", "up-regulation of DNA recombination"], "types": ["T045"], "canonical_name": "positive regulation of DNA recombination", "definition": "Any process that activates or increases the frequency, rate or extent of DNA recombination. [GOC:go_curators]"}
{"concept_id": "C1158525", "aliases": [], "types": ["T045"], "canonical_name": "RNA-mediated DNA recombination", "definition": "The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele. [GOC:jl, PMID:8380627]"}
{"concept_id": "C1158526", "aliases": [], "types": ["T045"], "canonical_name": "somatic cell DNA recombination", "definition": "Recombination occurring within or between DNA molecules in somatic cells. [GOC:ma]"}
{"concept_id": "C1158528", "aliases": ["somatic hypermutation of antibody genes"], "types": ["T045"], "canonical_name": "somatic hypermutation of immunoglobulin genes", "definition": "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007]"}
{"concept_id": "C1158530", "aliases": ["base-excision repair"], "types": ["T045"], "definition": "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. [ISBN:0815316194]", "canonical_name": "BER"}
{"concept_id": "C1158531", "aliases": [], "types": ["T045"], "canonical_name": "base-excision repair, AP site formation", "definition": "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired. [ISBN:0815316194]"}
{"concept_id": "C1158533", "aliases": [], "types": ["T045"], "canonical_name": "base-excision repair, DNA ligation", "definition": "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair. [ISBN:1550091131]"}
{"concept_id": "C1158534", "aliases": [], "types": ["T045"], "canonical_name": "base-excision repair, gap-filling", "definition": "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template. [ISBN:1550091131]"}
{"concept_id": "C1158535", "aliases": ["bypass DNA synthesis"], "types": ["T045"], "canonical_name": "translesion synthesis", "definition": "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. [GOC:elh, GOC:vw, PMID:10535901]"}
{"concept_id": "C1158536", "aliases": [], "types": ["T045"], "canonical_name": "DNA dealkylation involved in DNA repair", "definition": "The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT). [PMID:10946226]"}
{"concept_id": "C1158537", "aliases": [], "types": ["T045"], "definition": "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:elh]", "canonical_name": "double-strand break repair"}
{"concept_id": "C1158539", "aliases": [], "types": ["T045"], "canonical_name": "double-strand break repair via single-strand annealing", "definition": "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats. [PMID:11606529]"}
{"concept_id": "C1158541", "aliases": [], "types": ["T045"], "canonical_name": "double-strand break repair via single-strand annealing, removal of nonhomologous ends", "definition": "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. [PMID:10357855]"}
{"concept_id": "C1158543", "aliases": [], "types": ["T045"], "canonical_name": "error-free replication restart"}
{"concept_id": "C1158547", "aliases": [], "types": ["T045"], "canonical_name": "nucleotide-excision repair, DNA damage recognition", "definition": "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. [GOC:elh, PMID:10197977]"}
{"concept_id": "C1158548", "aliases": [], "types": ["T045"], "canonical_name": "transcription-coupled nucleotide-excision repair, DNA damage recognition", "definition": "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. [GOC:elh, PMID:10197977]"}
{"concept_id": "C1158549", "aliases": [], "types": ["T045"], "canonical_name": "nucleotide-excision repair, DNA damage removal", "definition": "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage. [GOC:elh, PMID:10197977]"}
{"concept_id": "C1158550", "aliases": [], "types": ["T045"], "canonical_name": "nucleotide-excision repair, DNA duplex unwinding", "definition": "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. [GOC:elh, PMID:10197977]"}
{"concept_id": "C1158551", "aliases": [], "types": ["T045"], "canonical_name": "nucleotide-excision repair, DNA gap filling", "definition": "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. [ISBN:0815316194]"}
{"concept_id": "C1158552", "aliases": ["nucleotide-excision repair, DNA incision, 3' to lesion"], "types": ["T045"], "canonical_name": "nucleotide-excision repair, DNA incision, 3'-to lesion", "definition": "The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. [GOC:elh, PMID:10197977]"}
{"concept_id": "C1158553", "aliases": ["nucleotide-excision repair, DNA incision, 5' to lesion"], "types": ["T045"], "canonical_name": "nucleotide-excision repair, DNA incision, 5'-to lesion", "definition": "The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage. [GOC:elh, PMID:10197977]"}
{"concept_id": "C1158554", "aliases": ["nucleotide-excision repair, preincision complex formation"], "types": ["T045"], "canonical_name": "nucleotide-excision repair, preincision complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. [GOC:elh, PMID:10197977]"}
{"concept_id": "C1158555", "aliases": [], "types": ["T045"], "canonical_name": "nucleotide-excision repair, preincision complex stabilization", "definition": "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. [GOC:elh, PMID:10197977]"}
{"concept_id": "C1158556", "aliases": [], "types": ["T045"], "canonical_name": "pyrimidine dimer repair by nucleotide-excision repair", "definition": "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. [GOC:elh]"}
{"concept_id": "C1158557", "aliases": ["transcription-coupled NER", "transcription-coupled repair", "transcription-coupled nucleotide-excision repair", "TCR"], "types": ["T045"], "definition": "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. [PMID:10197977, PMID:11900249]", "canonical_name": "TC-NER"}
{"concept_id": "C1158558", "aliases": ["postreplication DNA repair"], "types": ["T045"], "canonical_name": "postreplication repair", "definition": "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. [GOC:elh]"}
{"concept_id": "C1158559", "aliases": [], "types": ["T045"], "canonical_name": "pyrimidine dimer repair", "definition": "The repair of UV-induced T-T, C-T and C-C dimers. [ISBN:0815316194]"}
{"concept_id": "C1158560", "aliases": [], "types": ["T045"], "canonical_name": "photoreactive repair", "definition": "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines. [GOC:elh, PMID:10915863]"}
{"concept_id": "C1158561", "aliases": [], "types": ["T040"], "canonical_name": "regulation of DNA repair", "definition": "Any process that modulates the frequency, rate or extent of DNA repair. [GOC:go_curators]"}
{"concept_id": "C1158562", "aliases": ["downregulation of DNA repair", "down regulation of DNA repair", "down-regulation of DNA repair"], "types": ["T043"], "canonical_name": "negative regulation of DNA repair", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. [GOC:go_curators]"}
{"concept_id": "C1158563", "aliases": ["upregulation of DNA repair", "up-regulation of DNA repair", "up regulation of DNA repair"], "types": ["T045"], "canonical_name": "positive regulation of DNA repair", "definition": "Any process that activates or increases the frequency, rate or extent of DNA repair. [GOC:go_curators]"}
{"concept_id": "C1158564", "aliases": [], "types": ["T045"], "definition": "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. [PMID:18626472]", "canonical_name": "single strand break repair"}
{"concept_id": "C1158565", "aliases": [], "types": ["T045"], "canonical_name": "viral DNA repair", "definition": "The process of restoring viral DNA after damage or errors in replication. [ISBN:0781718325]"}
{"concept_id": "C1158566", "aliases": [], "types": ["T045"], "canonical_name": "recruitment of helicase-primase complex to DNA lesions", "definition": "The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair. [ISBN:0781718325]"}
{"concept_id": "C1158567", "aliases": ["production of siRNA involved in post-transcriptional gene silencing by RNA", "production of siRNA involved in chromatin silencing by small RNA", "RNA interference, production of siRNA", "production of siRNA involved in RNA interference", "chromatin silencing by small RNA, production of siRNA", "RNA interference, production of guide RNAs", "production of guide RNAs involved in RNA interference", "chromatin silencing by small RNA, production of guide RNAs", "production of guide RNAs involved in chromatin silencing by small RNA"], "types": ["T045"], "canonical_name": "siRNA processing", "definition": "A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase. [GOC:mah, PMID:11524674, PMID:19239886, PMID:20687832]"}
{"concept_id": "C1158570", "aliases": [], "types": ["T044"], "canonical_name": "purine nucleoside interconversion", "definition": "The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158571", "aliases": [], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside interconversion", "definition": "The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158572", "aliases": [], "types": ["T044"], "canonical_name": "purine nucleotide interconversion", "definition": "The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158573", "aliases": [], "types": ["T044"], "canonical_name": "purine deoxyribonucleotide interconversion", "definition": "The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158574", "aliases": [], "types": ["T044"], "canonical_name": "purine ribonucleotide interconversion", "definition": "The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158575", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine nucleoside interconversion", "definition": "The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158576", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside interconversion", "definition": "The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158577", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine nucleotide interconversion", "definition": "The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158578", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleotide interconversion", "definition": "The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158579", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine ribonucleotide interconversion", "definition": "The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C1158580", "aliases": ["nucleoside metabolism"], "types": ["T044"], "canonical_name": "nucleoside metabolic process", "definition": "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). [GOC:ma]"}
{"concept_id": "C1158581", "aliases": ["deoxyribonucleoside metabolism"], "types": ["T044"], "canonical_name": "deoxyribonucleoside metabolic process", "definition": "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:jl, ISBN:0140512713]"}
{"concept_id": "C1158582", "aliases": ["purine deoxyribonucleoside metabolism"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside metabolic process", "definition": "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1158583", "aliases": ["deoxyadenosine metabolism"], "types": ["T044"], "canonical_name": "deoxyadenosine metabolic process", "definition": "The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA. [GOC:go_curators]"}
{"concept_id": "C1158584", "aliases": ["deoxyguanosine metabolism"], "types": ["T044"], "canonical_name": "deoxyguanosine metabolic process", "definition": "The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. [GOC:jl]"}
{"concept_id": "C1158585", "aliases": ["pyrimidine deoxyribonucleoside metabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside metabolic process", "definition": "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]"}
{"concept_id": "C1158586", "aliases": ["deoxycytidine metabolism"], "types": ["T044"], "canonical_name": "deoxycytidine metabolic process", "definition": "The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. [GOC:go_curators]"}
{"concept_id": "C1158587", "aliases": ["deoxyinosine metabolism"], "types": ["T044"], "canonical_name": "deoxyinosine metabolic process", "definition": "The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside. [GOC:go_curators]"}
{"concept_id": "C1158588", "aliases": ["deoxyuridine metabolism"], "types": ["T044"], "canonical_name": "deoxyuridine metabolic process", "definition": "The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA. [GOC:go_curators]"}
{"concept_id": "C1158589", "aliases": ["deoxyribosylthymine metabolic process", "deoxyribosylthymine metabolism", "thymidine metabolism"], "types": ["T044"], "canonical_name": "thymidine metabolic process", "definition": "The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. [GOC:go_curators]"}
{"concept_id": "C1158590", "aliases": ["purine nucleoside metabolism"], "types": ["T044"], "canonical_name": "purine nucleoside metabolic process", "definition": "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:jl, ISBN:0140512713]"}
{"concept_id": "C1158591", "aliases": ["purine ribonucleoside metabolism"], "types": ["T044"], "canonical_name": "purine ribonucleoside metabolic process", "definition": "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:ai]"}
{"concept_id": "C1158592", "aliases": ["adenosine metabolism"], "types": ["T044"], "canonical_name": "adenosine metabolic process", "definition": "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. [GOC:go_curators]"}
{"concept_id": "C1158593", "aliases": ["bis(5'-nucleosidyl) oligophosphate metabolism"], "types": ["T044"], "canonical_name": "bis(5'-nucleosidyl) oligophosphate metabolic process", "definition": "The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. [GOC:mah, PMID:10970777]"}
{"concept_id": "C1158594", "aliases": ["diadenosine polyphosphate metabolism"], "types": ["T044"], "canonical_name": "diadenosine polyphosphate metabolic process", "definition": "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. [GOC:ai]"}
{"concept_id": "C1158595", "aliases": ["diadenosine tetraphosphate metabolism"], "types": ["T044"], "canonical_name": "diadenosine tetraphosphate metabolic process", "definition": "The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. [GOC:ai]"}
{"concept_id": "C1158596", "aliases": ["diadenosine triphosphate metabolism"], "types": ["T044"], "canonical_name": "diadenosine triphosphate metabolic process", "definition": "The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. [GOC:ai]"}
{"concept_id": "C1158597", "aliases": ["guanosine metabolism"], "types": ["T044"], "canonical_name": "guanosine metabolic process", "definition": "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution. [ISBN:0198506732]"}
{"concept_id": "C1158598", "aliases": ["7-methylguanosine metabolism"], "types": ["T044"], "canonical_name": "7-methylguanosine metabolic process", "definition": "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA. [ISBN:0198506732]"}
{"concept_id": "C1158599", "aliases": ["queuosine metabolism"], "types": ["T044"], "canonical_name": "queuosine metabolic process", "definition": "The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. [ISBN:0198506732]"}
{"concept_id": "C1158600", "aliases": ["guanosine pentaphosphate (5'-pppGpp-3') metabolism", "guanosine pentaphosphate metabolism", "guanosine pentaphosphate (5'-pppGpp-3') metabolic process"], "types": ["T044"], "canonical_name": "guanosine pentaphosphate metabolic process", "definition": "The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. [GOC:ai]"}
{"concept_id": "C1158601", "aliases": [], "types": ["T044"], "canonical_name": "guanosine phosphorolysis"}
{"concept_id": "C1158602", "aliases": ["guanosine tetraphosphate (5'-ppGpp-3') metabolic process", "guanosine tetraphosphate metabolism", "guanosine tetraphosphate (5'-ppGpp-3') metabolism"], "types": ["T044"], "canonical_name": "guanosine tetraphosphate metabolic process", "definition": "The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. [GOC:ai]"}
{"concept_id": "C1158603", "aliases": ["pyrimidine nucleoside metabolism"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside metabolic process", "definition": "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:jl, ISBN:0140512713]"}
{"concept_id": "C1158604", "aliases": ["pyrimidine ribonucleoside metabolism"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside metabolic process", "definition": "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:ai]"}
{"concept_id": "C1158605", "aliases": ["cytidine metabolism"], "types": ["T044"], "canonical_name": "cytidine metabolic process", "definition": "The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside. [GOC:go_curators]"}
{"concept_id": "C1158606", "aliases": ["inosine metabolism"], "types": ["T044"], "canonical_name": "inosine metabolic process", "definition": "The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. [GOC:go_curators]"}
{"concept_id": "C1158607", "aliases": ["uridine metabolism"], "types": ["T044"], "canonical_name": "uridine metabolic process", "definition": "The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. [GOC:go_curators]"}
{"concept_id": "C1158608", "aliases": ["regulation of nucleoside metabolism"], "types": ["T043"], "canonical_name": "regulation of nucleoside metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. [GOC:go_curators]"}
{"concept_id": "C1158609", "aliases": ["down regulation of nucleoside metabolic process", "downregulation of nucleoside metabolic process", "down-regulation of nucleoside metabolic process", "negative regulation of nucleoside metabolism"], "types": ["T043"], "canonical_name": "negative regulation of nucleoside metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. [GOC:go_curators]"}
{"concept_id": "C1158610", "aliases": ["positive regulation of nucleoside metabolism", "upregulation of nucleoside metabolic process", "up-regulation of nucleoside metabolic process", "up regulation of nucleoside metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of nucleoside metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. [GOC:go_curators]"}
{"concept_id": "C1158611", "aliases": ["ribonucleoside metabolism"], "types": ["T044"], "canonical_name": "ribonucleoside metabolic process", "definition": "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:jl]"}
{"concept_id": "C1158612", "aliases": ["cyclic nucleotide metabolism"], "types": ["T044"], "canonical_name": "cyclic nucleotide metabolic process", "definition": "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158613", "aliases": ["adenosine 3',5'-cyclophosphate metabolic process", "cAMP metabolism", "adenosine 3',5'-cyclophosphate metabolism", "cyclic AMP metabolic process", "cyclic AMP metabolism", "3',5' cAMP metabolic process", "3',5'-cAMP metabolic process", "3',5'-cAMP metabolism", "3',5' cAMP metabolism"], "types": ["T044"], "canonical_name": "cAMP metabolic process", "definition": "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). [GOC:go_curators]"}
{"concept_id": "C1158614", "aliases": ["cGMP metabolism"], "types": ["T044"], "canonical_name": "cGMP metabolic process", "definition": "The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. [GOC:go_curators]"}
{"concept_id": "C1158615", "aliases": ["deoxyribonucleotide metabolism"], "types": ["T044"], "canonical_name": "deoxyribonucleotide metabolic process", "definition": "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158616", "aliases": ["2'-deoxyribonucleotide metabolism"], "types": ["T044"], "canonical_name": "2'-deoxyribonucleotide metabolic process", "definition": "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:mah]"}
{"concept_id": "C1158617", "aliases": ["deoxyribonucleoside diphosphate metabolism"], "types": ["T044"], "canonical_name": "deoxyribonucleoside diphosphate metabolic process", "definition": "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158618", "aliases": ["purine deoxyribonucleoside diphosphate metabolism"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside diphosphate metabolic process", "definition": "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158619", "aliases": ["dADP metabolism"], "types": ["T044"], "canonical_name": "dADP metabolic process", "definition": "The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). [GOC:go_curators]"}
{"concept_id": "C1158620", "aliases": ["dGDP metabolism"], "types": ["T044"], "canonical_name": "dGDP metabolic process", "definition": "The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). [GOC:go_curators]"}
{"concept_id": "C1158621", "aliases": ["pyrimidine deoxyribonucleoside diphosphate metabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside diphosphate metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158622", "aliases": ["dCDP metabolism"], "types": ["T044"], "canonical_name": "dCDP metabolic process", "definition": "The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate. [GOC:go_curators]"}
{"concept_id": "C1158623", "aliases": ["dTDP metabolism"], "types": ["T044"], "canonical_name": "dTDP metabolic process", "definition": "The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate. [GOC:go_curators]"}
{"concept_id": "C1158624", "aliases": ["dUDP metabolism"], "types": ["T044"], "canonical_name": "dUDP metabolic process", "definition": "The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate. [GOC:go_curators]"}
{"concept_id": "C1158625", "aliases": ["deoxyribonucleoside monophosphate metabolism"], "types": ["T044"], "canonical_name": "deoxyribonucleoside monophosphate metabolic process", "definition": "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158626", "aliases": ["purine deoxyribonucleoside monophosphate metabolism"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside monophosphate metabolic process", "definition": "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158627", "aliases": ["dAMP metabolism"], "types": ["T044"], "canonical_name": "dAMP metabolic process", "definition": "The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). [GOC:go_curators]"}
{"concept_id": "C1158628", "aliases": ["dGMP metabolism"], "types": ["T044"], "canonical_name": "dGMP metabolic process", "definition": "The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). [GOC:go_curators]"}
{"concept_id": "C1158629", "aliases": ["pyrimidine deoxyribonucleoside monophosphate metabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside monophosphate metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158630", "aliases": ["dCMP metabolism"], "types": ["T044"], "canonical_name": "dCMP metabolic process", "definition": "The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158631", "aliases": ["dTMP metabolism"], "types": ["T044"], "canonical_name": "dTMP metabolic process", "definition": "The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). [GOC:go_curators]"}
{"concept_id": "C1158632", "aliases": ["dUMP metabolism"], "types": ["T044"], "canonical_name": "dUMP metabolic process", "definition": "The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate). [GOC:go_curators]"}
{"concept_id": "C1158633", "aliases": ["deoxyribonucleoside triphosphate metabolism"], "types": ["T044"], "canonical_name": "deoxyribonucleoside triphosphate metabolic process", "definition": "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158634", "aliases": ["purine deoxyribonucleoside triphosphate metabolism"], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside triphosphate metabolic process", "definition": "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158635", "aliases": ["dATP metabolism"], "types": ["T044"], "canonical_name": "dATP metabolic process", "definition": "The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). [GOC:go_curators]"}
{"concept_id": "C1158636", "aliases": ["dGTP metabolism"], "types": ["T044"], "canonical_name": "dGTP metabolic process", "definition": "The chemical reactions and pathways involving dGTP, guanosine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158637", "aliases": ["pyrimidine deoxyribonucleoside triphosphate metabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside triphosphate metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158638", "aliases": ["dCTP metabolism"], "types": ["T044"], "canonical_name": "dCTP metabolic process", "definition": "The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158639", "aliases": ["dTTP metabolism"], "types": ["T044"], "canonical_name": "dTTP metabolic process", "definition": "The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158640", "aliases": ["dUTP metabolism"], "types": ["T044"], "canonical_name": "dUTP metabolic process", "definition": "The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158641", "aliases": ["purine deoxyribonucleotide metabolism"], "types": ["T044"], "canonical_name": "purine deoxyribonucleotide metabolic process", "definition": "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158642", "aliases": ["pyrimidine deoxyribonucleotide metabolism"], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleotide metabolic process", "definition": "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158643", "aliases": ["nucleoside diphosphate metabolism"], "types": ["T044"], "canonical_name": "nucleoside diphosphate metabolic process", "definition": "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158644", "aliases": ["purine nucleoside diphosphate metabolism"], "types": ["T044"], "canonical_name": "purine nucleoside diphosphate metabolic process", "definition": "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158645", "aliases": ["purine ribonucleoside diphosphate metabolism"], "types": ["T044"], "canonical_name": "purine ribonucleoside diphosphate metabolic process", "definition": "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158646", "aliases": ["ADP metabolism"], "types": ["T044"], "canonical_name": "ADP metabolic process", "definition": "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. [GOC:go_curators]"}
{"concept_id": "C1158647", "aliases": ["GDP metabolism"], "types": ["T044"], "canonical_name": "GDP metabolic process", "definition": "The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. [GOC:ai]"}
{"concept_id": "C1158648", "aliases": ["IDP metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving IDP, inosine 5'-diphosphate. [GOC:ai]", "canonical_name": "IDP metabolic process"}
{"concept_id": "C1158649", "aliases": ["pyrimidine nucleoside diphosphate metabolism"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside diphosphate metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158650", "aliases": ["pyrimidine ribonucleoside diphosphate metabolism"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside diphosphate metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158651", "aliases": ["CDP metabolism"], "types": ["T044"], "canonical_name": "CDP metabolic process", "definition": "The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate. [GOC:ai]"}
{"concept_id": "C1158652", "aliases": ["TDP metabolism"], "types": ["T044"], "canonical_name": "TDP metabolic process", "definition": "The chemical reactions and pathways involving TDP, ribosylthymine diphosphate. [GOC:go_curators]"}
{"concept_id": "C1158653", "aliases": ["UDP metabolism"], "types": ["T044"], "canonical_name": "UDP metabolic process", "definition": "The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate. [GOC:go_curators]"}
{"concept_id": "C1158654", "aliases": ["ribonucleoside diphosphate metabolism"], "types": ["T044"], "canonical_name": "ribonucleoside diphosphate metabolic process", "definition": "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158655", "aliases": ["nucleoside monophosphate metabolism"], "types": ["T044"], "canonical_name": "nucleoside monophosphate metabolic process", "definition": "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158656", "aliases": ["purine nucleoside monophosphate metabolism"], "types": ["T044"], "canonical_name": "purine nucleoside monophosphate metabolic process", "definition": "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158657", "aliases": ["purine ribonucleoside monophosphate metabolism"], "types": ["T044"], "canonical_name": "purine ribonucleoside monophosphate metabolic process", "definition": "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158658", "aliases": ["AMP metabolism"], "types": ["T044"], "canonical_name": "AMP metabolic process", "definition": "The chemical reactions and pathways involving AMP, adenosine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158659", "aliases": ["GMP metabolism"], "types": ["T044"], "canonical_name": "GMP metabolic process", "definition": "The chemical reactions and pathways involving GMP, guanosine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158660", "aliases": ["IMP metabolism"], "types": ["T044"], "canonical_name": "IMP metabolic process", "definition": "The chemical reactions and pathways involving IMP, inosine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158661", "aliases": ["pyrimidine nucleoside monophosphate metabolism"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside monophosphate metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158662", "aliases": ["pyrimidine ribonucleoside monophosphate metabolism"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside monophosphate metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158663", "aliases": ["CMP metabolism"], "types": ["T044"], "canonical_name": "CMP metabolic process", "definition": "The chemical reactions and pathways involving CMP, cytidine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158664", "aliases": ["TMP metabolism"], "types": ["T044"], "canonical_name": "TMP metabolic process", "definition": "The chemical reactions and pathways involving TMP, ribosylthymine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158665", "aliases": ["UMP metabolism"], "types": ["T044"], "canonical_name": "UMP metabolic process", "definition": "The chemical reactions and pathways involving UMP, uridine monophosphate. [GOC:go_curators]"}
{"concept_id": "C1158666", "aliases": ["ribonucleoside monophosphate metabolism"], "types": ["T044"], "canonical_name": "ribonucleoside monophosphate metabolic process", "definition": "The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158667", "aliases": ["nucleoside triphosphate metabolism"], "types": ["T044"], "canonical_name": "nucleoside triphosphate metabolic process", "definition": "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158668", "aliases": ["purine nucleoside triphosphate metabolism"], "types": ["T044"], "canonical_name": "purine nucleoside triphosphate metabolic process", "definition": "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158669", "aliases": ["purine ribonucleoside triphosphate metabolism"], "types": ["T044"], "canonical_name": "purine ribonucleoside triphosphate metabolic process", "definition": "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158670", "aliases": ["GTP metabolism"], "types": ["T044"], "canonical_name": "GTP metabolic process", "definition": "The chemical reactions and pathways involving GTP, guanosine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158671", "aliases": ["ITP metabolism"], "types": ["T044"], "canonical_name": "ITP metabolic process", "definition": "The chemical reactions and pathways involving ITP, inosine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158672", "aliases": ["pyrimidine nucleoside triphosphate metabolism"], "types": ["T044"], "canonical_name": "pyrimidine nucleoside triphosphate metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158673", "aliases": ["pyrimidine ribonucleoside triphosphate metabolism"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside triphosphate metabolic process", "definition": "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158674", "aliases": ["CTP metabolism"], "types": ["T044"], "canonical_name": "CTP metabolic process", "definition": "The chemical reactions and pathways involving CTP, cytidine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158675", "aliases": ["TTP metabolism"], "types": ["T044"], "canonical_name": "TTP metabolic process", "definition": "The chemical reactions and pathways involving TTP, ribosylthymine triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158676", "aliases": ["UTP metabolism"], "types": ["T044"], "canonical_name": "UTP metabolic process", "definition": "The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. [GOC:go_curators]"}
{"concept_id": "C1158677", "aliases": ["ribonucleoside triphosphate metabolism"], "types": ["T044"], "canonical_name": "ribonucleoside triphosphate metabolic process", "definition": "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158678", "aliases": ["purine nucleotide metabolism"], "types": ["T044"], "canonical_name": "purine nucleotide metabolic process", "definition": "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158679", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside diphosphate phosphorylation", "definition": "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate. [GOC:ai]"}
{"concept_id": "C1158680", "aliases": ["purine ribonucleotide metabolism"], "types": ["T044"], "canonical_name": "purine ribonucleotide metabolic process", "definition": "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158681", "aliases": [], "types": ["T044"], "canonical_name": "purine salvage"}
{"concept_id": "C1158683", "aliases": ["pyrimidine nucleotide metabolism"], "types": ["T044"], "canonical_name": "pyrimidine nucleotide metabolic process", "definition": "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158684", "aliases": ["pyrimidine ribonucleotide metabolism"], "types": ["T044"], "canonical_name": "pyrimidine ribonucleotide metabolic process", "definition": "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158685", "aliases": ["regulation of nucleotide metabolism"], "types": ["T044"], "canonical_name": "regulation of nucleotide metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. [GOC:go_curators]"}
{"concept_id": "C1158686", "aliases": ["downregulation of nucleotide metabolic process", "down regulation of nucleotide metabolic process", "down-regulation of nucleotide metabolic process", "negative regulation of nucleotide metabolism"], "types": ["T043"], "canonical_name": "negative regulation of nucleotide metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. [GOC:go_curators]"}
{"concept_id": "C1158687", "aliases": ["upregulation of nucleotide metabolic process", "up-regulation of nucleotide metabolic process", "up regulation of nucleotide metabolic process", "positive regulation of nucleotide metabolism"], "types": ["T043"], "canonical_name": "positive regulation of nucleotide metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. [GOC:go_curators]"}
{"concept_id": "C1158688", "aliases": ["ribonucleotide metabolism"], "types": ["T044"], "canonical_name": "ribonucleotide metabolic process", "definition": "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158689", "aliases": ["nucleotide-sugar metabolism"], "types": ["T044"], "canonical_name": "nucleotide-sugar metabolic process", "definition": "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [ISBN:0198506732]"}
{"concept_id": "C1158690", "aliases": ["regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism"], "types": ["T043"], "canonical_name": "regulation of nucleobase-containing compound metabolic process", "definition": "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:go_curators]"}
{"concept_id": "C1158691", "aliases": ["down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism", "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of nucleobase-containing compound metabolic process", "definition": "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:go_curators]"}
{"concept_id": "C1158692", "aliases": ["upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism", "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of nucleobase-containing compound metabolic process", "definition": "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:go_curators]"}
{"concept_id": "C1158693", "aliases": ["RNA localisation", "establishment and maintenance of RNA localization"], "types": ["T043"], "canonical_name": "RNA localization", "definition": "A process in which RNA is transported to, or maintained in, a specific location. [GOC:ai]"}
{"concept_id": "C1158694", "aliases": ["cytoplasmic tRNA, mitochondrial import", "mitochondrial import of cytoplasmic tRNA", "cytoplasmic tRNA import into mitochondrion", "cytoplasmic tRNA transport into mitochondrion", "cytoplasmic tRNA import into mitochondria"], "types": ["T043"], "canonical_name": "tRNA import into mitochondrion", "definition": "The process in which a tRNA is transported from the cytosol into the mitochondrial matrix. [GOC:ma, PMID:10988073, PMID:11121736]"}
{"concept_id": "C1158695", "aliases": ["mtRNA localization", "establishment and maintenance of mitochondrial RNA localization", "mitochondrial RNA localisation"], "types": ["T043"], "canonical_name": "mitochondrial RNA localization", "definition": "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location. [GOC:ai]"}
{"concept_id": "C1158696", "aliases": ["mitochondrial rRNA export from mitochondria", "mitochondrial rRNA export", "mitochondrial rRNA transport from mitochondrion", "export of mitochondrial rRNA", "mitochondrial rRNA export out of mitochondrion", "mitochondrial rRNA, mitochondrial export"], "types": ["T043"], "canonical_name": "mitochondrial rRNA export from mitochondrion", "definition": "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol. [GOC:ai, PMID:28115039]"}
{"concept_id": "C1158697", "aliases": ["mitochondrial lrRNA, mitochondrial export", "mitochondrial lrRNA export from mitochondria", "mitochondrial lrRNA transport from mitochondrion", "mitochondrial lrRNA export out of mitochondrion", "mitochondrial lrRNA export", "export of mitochondrial lrRNA"], "types": ["T043"], "canonical_name": "mitochondrial lrRNA export from mitochondrion", "definition": "The process in which a lrRNA, large subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol. [GOC:ai]"}
{"concept_id": "C1158698", "aliases": ["export of mitochondrial srRNA", "mitochondrial srRNA export from mitochondria", "mitochondrial srRNA export out of mitochondrion", "mitochondrial srRNA, mitochondrial export", "mitochondrial srRNA transport from mitochondrion", "mitochondrial srRNA export"], "types": ["T043"], "canonical_name": "mitochondrial srRNA export from mitochondrion", "definition": "The process in which a srRNA, small subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol. [GOC:ai]"}
{"concept_id": "C1158699", "aliases": ["pole plasm mitochondrial rRNA localisation", "establishment and maintenance of mitochondrial rRNA localization in pole plasm", "oocyte pole plasm mitochondrial rRNA localization"], "types": ["T043"], "canonical_name": "pole plasm mitochondrial rRNA localization", "definition": "Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. [ISBN:0879694238]"}
{"concept_id": "C1158700", "aliases": ["establishment and maintenance of mitochondrial lrRNA localization in pole plasm", "pole plasm mitochondrial lrRNA localisation", "oocyte pole plasm mitochondrial lrRNA localization"], "types": ["T043"], "canonical_name": "pole plasm mitochondrial lrRNA localization", "definition": "Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. [ISBN:0879694238]"}
{"concept_id": "C1158701", "aliases": ["oocyte pole plasm mitochondrial srRNA localization", "establishment and maintenance of mitochondrial localization in pole plasm", "pole plasm mitochondrial srRNA localisation"], "types": ["T043"], "canonical_name": "pole plasm mitochondrial srRNA localization", "definition": "Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. [ISBN:0879694238]"}
{"concept_id": "C1158702", "aliases": ["establishment and maintenance of intracellular RNA localization", "mRNA localization, intracellular", "intracellular mRNA localisation"], "types": ["T043"], "canonical_name": "intracellular mRNA localization", "definition": "Any process in which mRNA is transported to, or maintained in, a specific location within the cell. [GOC:ai]"}
{"concept_id": "C1158703", "aliases": ["establishment and maintenance of mRNA localization in pole plasm", "oocyte pole plasm mRNA localization", "pole plasm mRNA localisation", "establishment and maintenance of pole plasm mRNA localization"], "types": ["T043"], "canonical_name": "pole plasm mRNA localization", "definition": "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. [GOC:ai]"}
{"concept_id": "C1158704", "aliases": ["establishment of oocyte pole plasm mRNA localization", "establishment of pole plasm mRNA localisation"], "types": ["T043"], "canonical_name": "establishment of pole plasm mRNA localization", "definition": "Any process that results in the directed movement of mRNA to the oocyte pole plasm. [GOC:bf]"}
{"concept_id": "C1158705", "aliases": ["maintenance of pole plasm mRNA localization", "maintenance of oocyte pole plasm mRNA localization"], "types": ["T043"], "canonical_name": "maintenance of pole plasm mRNA location", "definition": "The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster. [GOC:bf, GOC:dph, GOC:tb]"}
{"concept_id": "C1158706", "aliases": ["establishment and maintenance of bicoid mRNA localization", "bicoid mRNA localisation"], "types": ["T043"], "canonical_name": "bicoid mRNA localization", "definition": "Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis. [GOC:go_curators]"}
{"concept_id": "C1158707", "aliases": ["regulation of bicoid mRNA localisation"], "types": ["T043"], "canonical_name": "regulation of bicoid mRNA localization", "definition": "Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location. [GOC:hb]"}
{"concept_id": "C1158708", "aliases": ["down regulation of bicoid mRNA localization", "downregulation of bicoid mRNA localization", "negative regulation of bicoid mRNA localisation", "down-regulation of bicoid mRNA localization"], "types": ["T045"], "canonical_name": "negative regulation of bicoid mRNA localization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location. [GOC:go_curators]"}
{"concept_id": "C1158709", "aliases": ["upregulation of bicoid mRNA localization", "positive regulation of bicoid mRNA localisation", "up-regulation of bicoid mRNA localization", "up regulation of bicoid mRNA localization"], "types": ["T045"], "canonical_name": "positive regulation of bicoid mRNA localization", "definition": "Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location. [GOC:go_curators]"}
{"concept_id": "C1158710", "aliases": ["pole plasm oskar mRNA localisation", "establishment and maintenance of pole plasm oskar mRNA localization", "establishment and maintenance of oskar mRNA localization in pole plasm", "oocyte pole plasm oskar mRNA localization"], "types": ["T043"], "canonical_name": "pole plasm oskar mRNA localization", "definition": "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. [GOC:go_curators]"}
{"concept_id": "C1158711", "aliases": ["regulation of oocyte pole plasm oskar mRNA localization", "regulation of pole plasm oskar mRNA localisation"], "types": ["T043"], "canonical_name": "regulation of pole plasm oskar mRNA localization", "definition": "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. [GOC:hb]"}
{"concept_id": "C1158712", "aliases": ["negative regulation of pole plasm oskar mRNA localisation", "downregulation of pole plasm oskar mRNA localization", "down regulation of pole plasm oskar mRNA localization", "down-regulation of pole plasm oskar mRNA localization", "negative regulation of oocyte pole plasm oskar mRNA localization"], "types": ["T045"], "canonical_name": "negative regulation of pole plasm oskar mRNA localization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. [GOC:go_curators]"}
{"concept_id": "C1158713", "aliases": ["up regulation of pole plasm oskar mRNA localization", "positive regulation of pole plasm oskar mRNA localisation", "upregulation of pole plasm oskar mRNA localization", "positive regulation of oocyte pole plasm oskar mRNA localization", "up-regulation of pole plasm oskar mRNA localization"], "types": ["T043"], "canonical_name": "positive regulation of pole plasm oskar mRNA localization", "definition": "Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. [GOC:go_curators]"}
{"concept_id": "C1158714", "aliases": ["oocyte pole plasm RNA localization", "establishment and maintenance of pole plasm RNA localization", "pole plasm RNA localisation"], "types": ["T043"], "canonical_name": "pole plasm RNA localization", "definition": "Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. [GOC:ai]"}
{"concept_id": "C1158715", "aliases": ["RNA export from cell nucleus", "RNA export out of nucleus", "RNA-nucleus export", "RNA transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "RNA export from nucleus", "definition": "The directed movement of RNA from the nucleus to the cytoplasm. [GOC:ma]"}
{"concept_id": "C1158716", "aliases": ["mRNA export from cell nucleus", "mRNA export out of nucleus", "mRNA-nucleus export", "mRNA transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "mRNA export from nucleus", "definition": "The directed movement of mRNA from the nucleus to the cytoplasm. [GOC:ma]"}
{"concept_id": "C1158717", "aliases": ["intronless viral mRNA export from host cell nucleus", "intronless viral mRNA export out of nucleus", "intronless viral mRNA-nucleus export", "intronless viral mRNA export from host nucleus", "intronless viral mRNA transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "viral mRNA export from host cell nucleus", "definition": "The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation. [PMID:11598019]"}
{"concept_id": "C1158718", "aliases": ["poly(A)+ mRNA-nucleus export", "poly(A) mRNA export from nucleus", "poly(A)+ mRNA export out of nucleus", "poly(A)+ mRNA export from cell nucleus", "poly(A)+ mRNA transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "poly(A)+ mRNA export from nucleus", "definition": "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. [GOC:ai]"}
{"concept_id": "C1158719", "aliases": ["rRNA export out of nucleus", "rRNA transport from nucleus to cytoplasm", "rRNA export from cell nucleus", "rRNA-nucleus export"], "types": ["T043"], "canonical_name": "rRNA export from nucleus", "definition": "The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins. [GOC:ma, GOC:mah]"}
{"concept_id": "C1158720", "aliases": ["snRNA export out of nucleus", "snRNA-nucleus export", "snRNA export from cell nucleus", "snRNA transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "snRNA export from nucleus", "definition": "The directed movement of snRNA from the nucleus to the cytoplasm. [GOC:ma]"}
{"concept_id": "C1158721", "aliases": ["tRNA export out of nucleus", "tRNA export from cell nucleus", "tRNA transport from nucleus to cytoplasm", "tRNA-nucleus export"], "types": ["T043"], "canonical_name": "tRNA export from nucleus", "definition": "The directed movement of tRNA from the nucleus to the cytoplasm. [GOC:ma]"}
{"concept_id": "C1158722", "aliases": ["RNA transport from cytoplasm to nucleus", "RNA import into cell nucleus", "RNA-nucleus import"], "types": ["T043"], "canonical_name": "RNA import into nucleus", "definition": "The import of RNA from the cytoplasm to the nucleus. [GOC:ma]"}
{"concept_id": "C1158723", "aliases": ["mRNA metabolism"], "types": ["T045"], "canonical_name": "mRNA metabolic process", "definition": "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. [ISBN:0198506732]"}
{"concept_id": "C1158724", "aliases": ["histone mRNA metabolism"], "types": ["T045"], "canonical_name": "histone mRNA metabolic process", "definition": "The chemical reactions and pathways involving an mRNA encoding a histone. [GOC:krc, GOC:mah, PMID:17855393]"}
{"concept_id": "C1158725", "aliases": [], "types": ["T045"], "canonical_name": "histone mRNA 3' end processing"}
{"concept_id": "C1158726", "aliases": [], "types": ["T045"], "canonical_name": "mRNA cleavage", "definition": "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. [GOC:mah]"}
{"concept_id": "C1158727", "aliases": ["mRNA polyadenylation"], "types": ["T045"], "definition": "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. [ISBN:0198506732]", "canonical_name": "mRNA polyadenylylation"}
{"concept_id": "C1158729", "aliases": [], "types": ["T045"], "canonical_name": "mRNA maturation"}
{"concept_id": "C1158730", "aliases": [], "types": ["T045"], "canonical_name": "mRNA modification", "definition": "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. [GOC:curators]"}
{"concept_id": "C1158733", "aliases": [], "types": ["T045"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:krc]", "canonical_name": "3'-splice site cleavage, exon ligation"}
{"concept_id": "C1158734", "aliases": [], "types": ["T045"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:krc]", "canonical_name": "lariat formation, 5'-splice site cleavage"}
{"concept_id": "C1158737", "aliases": [], "types": ["T045"], "definition": "Selection of a splice site by components of the assembling spliceosome. [GOC:krc, ISBN:0879695897]", "canonical_name": "mRNA splice site selection"}
{"concept_id": "C1158739", "aliases": ["spliceosomal tri-snRNP assembly", "spliceosomal tri-snRNP complex assembly"], "types": ["T045"], "definition": "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. [ISBN:0879695897, PMID:9452384]", "canonical_name": "assembly of spliceosomal tri-snRNP"}
{"concept_id": "C1158740", "aliases": [], "types": ["T043"], "canonical_name": "spliceosome assembly"}
{"concept_id": "C1158741", "aliases": [], "types": ["T045"], "canonical_name": "splicing AT-AC intron"}
{"concept_id": "C1158742", "aliases": [], "types": ["T045"], "canonical_name": "nuclear mRNA splicing via U2-type spliceosome"}
{"concept_id": "C1158743", "aliases": ["snoRNA capping", "snRNA capping"], "types": ["T045"], "canonical_name": "snRNA capping", "definition": "OBSOLETE. The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript. [GOC:mah]"}
{"concept_id": "C1158744", "aliases": [], "types": ["T045"], "definition": "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. [GOC:go_curators, ISBN:1555811337]", "canonical_name": "RNA modification"}
{"concept_id": "C1158745", "aliases": ["pseudouridylation"], "types": ["T045"], "canonical_name": "pseudouridine synthesis", "definition": "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. [GOC:hjd, GOC:mah]"}
{"concept_id": "C1158746", "aliases": ["base conversion/substitution editing"], "types": ["T045"], "canonical_name": "base conversion or substitution editing", "definition": "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s). [PMID:11092837]"}
{"concept_id": "C1158747", "aliases": [], "types": ["T045"], "canonical_name": "adenosine to inosine editing", "definition": "The conversion of an adenosine residue to inosine in an RNA molecule by deamination. [PMID:11092837]"}
{"concept_id": "C1158748", "aliases": [], "types": ["T045"], "canonical_name": "cytidine to uridine editing", "definition": "The conversion of a cytosine residue to uridine in an RNA molecule by deamination. [PMID:11092837]"}
{"concept_id": "C1158749", "aliases": [], "types": ["T045"], "canonical_name": "uridine to cytidine editing", "definition": "The conversion of a uridine residue to cytosine in an RNA molecule by amination. [PMID:11092837]"}
{"concept_id": "C1158755", "aliases": [], "types": ["T045"], "canonical_name": "tRNA methylation", "definition": "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. [GOC:mah]"}
{"concept_id": "C1158756", "aliases": [], "types": ["T045"], "canonical_name": "rRNA modification", "definition": "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. [GOC:curators]"}
{"concept_id": "C1158757", "aliases": [], "types": ["T045"], "canonical_name": "snRNA modification", "definition": "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA. [GOC:jl]"}
{"concept_id": "C1158758", "aliases": [], "types": ["T045"], "canonical_name": "tRNA modification", "definition": "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. [GOC:curators]"}
{"concept_id": "C1158760", "aliases": [], "types": ["T045"], "canonical_name": "tRNA-Y splicing", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:krc]"}
{"concept_id": "C1158761", "aliases": ["snRNA production", "snRNA maturation"], "types": ["T044"], "canonical_name": "snRNA processing", "definition": "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres. [PMID:15196465, PMID:31815536]"}
{"concept_id": "C1158762", "aliases": ["tRNA maturation"], "types": ["T045"], "canonical_name": "tRNA processing", "definition": "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. [GOC:jl, PMID:12533506]"}
{"concept_id": "C1158763", "aliases": ["ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity", "CCA-adding enzyme activity", "CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity"], "types": ["T045"], "canonical_name": "tRNA 3'-terminal CCA addition", "definition": "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition. [EC:2.7.7.72, GOC:go_curators]"}
{"concept_id": "C1158764", "aliases": ["tRNA 5' leader removal"], "types": ["T045"], "canonical_name": "tRNA 5'-leader removal", "definition": "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. [PMID:11592395]"}
{"concept_id": "C1158765", "aliases": [], "types": ["T045"], "canonical_name": "RNA repair", "definition": "Any process that results in the repair of damaged RNA. [PMID:11000254, PMID:11070075, UniProtKB-KW:KW-0692]"}
{"concept_id": "C1158766", "aliases": ["rRNA metabolism"], "types": ["T045"], "canonical_name": "rRNA metabolic process", "definition": "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. [ISBN:0198506732]"}
{"concept_id": "C1158767", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA metabolism"}
{"concept_id": "C1158768", "aliases": ["snRNA metabolism"], "types": ["T045"], "canonical_name": "snRNA metabolic process", "definition": "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. [ISBN:0198506732]"}
{"concept_id": "C1158769", "aliases": ["tRNA metabolism"], "types": ["T045"], "canonical_name": "tRNA metabolic process", "definition": "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. [ISBN:0198506732]"}
{"concept_id": "C1158770", "aliases": [], "types": ["T045"], "definition": "The control of gene expression at the level of RNA transcription.", "canonical_name": "transcriptional control"}
{"concept_id": "C1158772", "aliases": ["down regulation of gene-specific transcription", "inhibition of transcription, DNA-dependent", "downregulation of transcription, DNA-dependent", "downregulation of gene-specific transcription", "down-regulation of gene-specific transcription", "down regulation of transcription, DNA-dependent", "negative regulation of transcription, DNA-dependent", "negative regulation of gene-specific transcription", "inhibition of gene-specific transcription", "down-regulation of transcription, DNA-dependent", "negative regulation of cellular transcription, DNA-dependent"], "types": ["T045"], "canonical_name": "negative regulation of transcription, DNA-templated", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C1158773", "aliases": ["carbon catabolite repression of transcription", "negative regulation of transcription by carbon catabolites"], "types": ["T045"], "definition": "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. [GOC:mah, ISBN:0198506732, PMID:11018147, PMID:18359269, PMID:9618445]", "canonical_name": "carbon catabolite repression"}
{"concept_id": "C1158774", "aliases": ["down regulation of transcription by glucose", "glucose effect", "glucose repression", "down-regulation of transcription by glucose", "downregulation of transcription by glucose"], "types": ["T045"], "canonical_name": "carbon catabolite repression of transcription by glucose", "definition": "A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. [ISBN:0198506732, PMID:11018147]"}
{"concept_id": "C1158775", "aliases": ["negative regulation of transcription from RNA polymerase I promoter", "negative regulation of transcription from Pol I promoter", "down regulation of transcription from RNA polymerase I promoter", "downregulation of transcription from RNA polymerase I promoter", "down-regulation of transcription from RNA polymerase I promoter"], "types": ["T045"], "canonical_name": "negative regulation of transcription by RNA polymerase I", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I. [GOC:go_curators]"}
{"concept_id": "C1158776", "aliases": ["inhibition of transcription from RNA polymerase II promoter", "negative regulation of transcription from Pol II promoter", "down regulation of transcription from RNA polymerase II promoter", "negative regulation of transcription from RNA polymerase II promoter", "down-regulation of transcription from RNA polymerase II promoter", "downregulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of transcription by RNA polymerase II", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C1158777", "aliases": ["downregulation of global transcription from RNA polymerase II promoter", "negative regulation of transcription from RNA polymerase II promoter, global", "down-regulation of global transcription from RNA polymerase II promoter", "down regulation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of global transcription from Pol II promoter"}
{"concept_id": "C1158779", "aliases": ["downregulation of transcription from RNA polymerase III promoter", "down-regulation of transcription from RNA polymerase III promoter", "negative regulation of transcription from RNA polymerase III promoter", "down regulation of transcription from RNA polymerase III promoter", "negative regulation of transcription from Pol III promoter"], "types": ["T045"], "canonical_name": "negative regulation of transcription by RNA polymerase III", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III. [GOC:go_curators]"}
{"concept_id": "C1158782", "aliases": ["positive regulation of gene-specific transcription", "activation of gene-specific transcription", "activation of transcription, DNA-dependent", "up regulation of transcription, DNA-dependent", "up regulation of gene-specific transcription", "stimulation of gene-specific transcription", "positive regulation of cellular transcription, DNA-dependent", "upregulation of gene-specific transcription", "up-regulation of gene-specific transcription", "stimulation of transcription, DNA-dependent", "positive regulation of transcription, DNA-dependent", "upregulation of transcription, DNA-dependent", "up-regulation of transcription, DNA-dependent"], "types": ["T045"], "canonical_name": "positive regulation of transcription, DNA-templated", "definition": "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C1158783", "aliases": ["positive regulation of transcription by carbon catabolites"], "types": ["T045"], "canonical_name": "carbon catabolite activation of transcription", "definition": "A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. [GOC:mah, PMID:10559153]"}
{"concept_id": "C1158784", "aliases": ["upregulation of transcription by glucose", "up-regulation of transcription by glucose", "up regulation of transcription by glucose"], "types": ["T045"], "canonical_name": "positive regulation of transcription by glucose", "definition": "Any process involving glucose that activates or increases the rate of transcription. [GOC:go_curators]"}
{"concept_id": "C1158785", "aliases": ["positive regulation of transcription from Pol I promoter", "up regulation of transcription from RNA polymerase I promoter", "upregulation of transcription from RNA polymerase I promoter", "up-regulation of transcription from RNA polymerase I promoter", "positive regulation of transcription from RNA polymerase I promoter"], "types": ["T045"], "canonical_name": "positive regulation of transcription by RNA polymerase I", "definition": "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C1158786", "aliases": ["stimulation of global transcription from RNA polymerase II promoter", "activation of transcription from RNA polymerase II promoter", "up regulation of transcription from RNA polymerase II promoter", "positive regulation of gene-specific transcription from RNA polymerase II promoter", "positive regulation of transcription from RNA polymerase II promoter", "upregulation of global transcription from RNA polymerase II promoter", "stimulation of transcription from RNA polymerase II promoter", "upregulation of transcription from RNA polymerase II promoter", "positive regulation of global transcription from Pol II promoter", "positive regulation of transcription from Pol II promoter", "positive regulation of transcription from RNA polymerase II promoter, global", "up-regulation of global transcription from RNA polymerase II promoter", "up regulation of global transcription from RNA polymerase II promoter", "up-regulation of transcription from RNA polymerase II promoter", "activation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "positive regulation of transcription by RNA polymerase II", "definition": "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C1158789", "aliases": ["positive regulation of transcription from RNA polymerase III promoter", "up regulation of transcription from RNA polymerase III promoter", "upregulation of transcription from RNA polymerase III promoter", "up-regulation of transcription from RNA polymerase III promoter", "positive regulation of transcription from Pol III promoter"], "types": ["T045"], "canonical_name": "positive regulation of transcription by RNA polymerase III", "definition": "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C1158791", "aliases": ["regulation of cellular transcription, DNA-dependent", "regulation of transcription, DNA-dependent"], "types": ["T045"], "canonical_name": "regulation of transcription, DNA-templated", "definition": "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C1158792", "aliases": ["regulation of transcription by carbon catabolites"], "types": ["T045"], "canonical_name": "carbon catabolite regulation of transcription", "definition": "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. [GOC:go_curators, GOC:mah, PMID:18359269, PMID:9618445]"}
{"concept_id": "C1158793", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription by glucose", "definition": "Any process involving glucose that modulates the frequency, rate or extent or transcription. [GOC:go_curators]"}
{"concept_id": "C1158794", "aliases": ["regulation of transcription from RNA polymerase I promoter", "regulation of transcription from Pol I promoter"], "types": ["T045"], "canonical_name": "regulation of transcription by RNA polymerase I", "definition": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I. [GOC:go_curators]"}
{"concept_id": "C1158795", "aliases": ["regulation of transcription from RNA polymerase II promoter", "regulation of transcription from Pol II promoter"], "types": ["T045"], "canonical_name": "regulation of transcription by RNA polymerase II", "definition": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C1158796", "aliases": ["regulation of global transcription from Pol II promoter", "regulation of transcription from RNA polymerase II promoter, global"], "types": ["T045"], "canonical_name": "global transcription regulation from Pol II promoter"}
{"concept_id": "C1158798", "aliases": ["regulation of transcription from Pol III promoter", "regulation of transcription from RNA polymerase III promoter"], "types": ["T045"], "canonical_name": "regulation of transcription by RNA polymerase III", "definition": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III. [GOC:go_curators]"}
{"concept_id": "C1158799", "aliases": ["regulation of mating-type specific transcription, DNA-dependent", "mating-type specific transcriptional control"], "types": ["T045"], "canonical_name": "regulation of mating-type specific transcription, DNA-templated", "definition": "Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C1158800", "aliases": [], "types": ["T043"], "canonical_name": "regulation of viral transcription", "definition": "Any process that modulates the frequency, rate or extent of the transcription of the viral genome. [GOC:ai]"}
{"concept_id": "C1158801", "aliases": ["DNA-dependent transcription", "transcription, DNA-dependent"], "types": ["T045"], "canonical_name": "transcription, DNA-templated", "definition": "The cellular synthesis of RNA on a template of DNA. [GOC:jl, GOC:txnOH]"}
{"concept_id": "C1158802", "aliases": [], "types": ["T045"], "canonical_name": "antisense RNA transcription", "definition": "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. [GOC:jl]"}
{"concept_id": "C1158803", "aliases": [], "types": ["T045"], "canonical_name": "RNA elongation"}
{"concept_id": "C1158804", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA transcription"}
{"concept_id": "C1158805", "aliases": ["transcription from mitochondrial promoter"], "types": ["T045"], "canonical_name": "mitochondrial transcription", "definition": "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. [GOC:jl, PMID:23632312]"}
{"concept_id": "C1158806", "aliases": ["RNA elongation from mitochondrial promoter"], "types": ["T045"], "canonical_name": "transcription elongation from mitochondrial promoter", "definition": "The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1158807", "aliases": ["mitochondrial transcription termination", "RNA transcription termination from mitochondrial promoter"], "types": ["T045"], "canonical_name": "termination of mitochondrial transcription", "definition": "The process in which the synthesis of an RNA molecule using a mitochondrial DNA template is completed. [GOC:mah]"}
{"concept_id": "C1158808", "aliases": [], "types": ["T045"], "canonical_name": "transcription initiation from mitochondrial promoter", "definition": "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase. [GOC:mah]"}
{"concept_id": "C1158809", "aliases": ["transcription from RNA polymerase I promoter", "transcription from Pol I promoter"], "types": ["T045"], "canonical_name": "transcription by RNA polymerase I", "definition": "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. [GOC:jl, GOC:txnOH]"}
{"concept_id": "C1158810", "aliases": ["RNA elongation from Pol I promoter"], "types": ["T045"], "canonical_name": "transcription elongation from RNA polymerase I promoter", "definition": "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1158811", "aliases": [], "types": ["T045"], "canonical_name": "rRNA transcription", "definition": "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1158812", "aliases": ["transcription initiation from Pol I promoter"], "types": ["T045"], "canonical_name": "transcription initiation from RNA polymerase I promoter", "definition": "Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1158813", "aliases": ["transcription termination from Pol I promoter", "transcription termination from RNA polymerase I promoter", "RNA polymerase I transcription termination"], "types": ["T045"], "canonical_name": "termination of RNA polymerase I transcription", "definition": "The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit. [GOC:mah, GOC:txnOH, PMID:10684922]"}
{"concept_id": "C1158814", "aliases": ["transcription from RNA polymerase II promoter", "transcription from Pol II promoter"], "types": ["T045"], "canonical_name": "transcription by RNA polymerase II", "definition": "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]"}
{"concept_id": "C1158815", "aliases": ["CTD domain phosphorylation of RNA polymerase II", "generation of hyperphosphorylated CTD of RNA polymerase II", "hyperphosphorylation of RNA polymerase II C-terminal domain", "generation of II(0) form of RNA polymerase II"], "types": ["T045"], "canonical_name": "phosphorylation of RNA polymerase II C-terminal domain", "definition": "The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. [GOC:krc, GOC:mah, PMID:17079683]"}
{"concept_id": "C1158816", "aliases": ["cellular mRNA transcription"], "types": ["T045"], "canonical_name": "mRNA transcription", "definition": "The cellular synthesis of messenger RNA (mRNA) from a DNA template. [GOC:jl]"}
{"concept_id": "C1158817", "aliases": [], "types": ["T045"], "definition": "The process by which a viral genome, or part of a viral genome, is transcribed within the host cell. [GOC:jl, ISBN:0781702534]", "canonical_name": "viral transcription"}
{"concept_id": "C1158818", "aliases": ["(delayed) early viral mRNA transcription"], "types": ["T045"], "canonical_name": "middle viral transcription", "definition": "The viral transcription that takes place after early transcription in the viral life cycle, and which involves the transcription of genes required for replication. [GOC:bf, GOC:jl]"}
{"concept_id": "C1158820", "aliases": ["late viral mRNA transcription"], "types": ["T045"], "canonical_name": "late viral transcription", "definition": "The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins. [GOC:bf, GOC:jh2, GOC:jl]"}
{"concept_id": "C1158821", "aliases": ["RNA elongation from Pol II promoter"], "types": ["T045"], "canonical_name": "transcription elongation from RNA polymerase II promoter", "definition": "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1158822", "aliases": [], "types": ["T045"], "canonical_name": "snRNA transcription", "definition": "The synthesis of small nuclear RNA (snRNA) from a DNA template. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1158823", "aliases": ["transcription initiation from Pol II promoter"], "types": ["T045"], "canonical_name": "transcription initiation from RNA polymerase II promoter", "definition": "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1158824", "aliases": ["transcription termination from RNA polymerase II promoter", "transcription termination from Pol II promoter", "RNA 3'-end formation by RNA polymerase II", "RNA polymerase II transcription termination"], "types": ["T045"], "canonical_name": "termination of RNA polymerase II transcription", "definition": "The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1158825", "aliases": ["transcription from Pol III promoter", "transcription from RNA polymerase III promoter"], "types": ["T045"], "canonical_name": "transcription by RNA polymerase III", "definition": "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. [GOC:jl, GOC:txnOH, PMID:12381659]"}
{"concept_id": "C1158826", "aliases": ["RNA elongation from Pol III promoter"], "types": ["T045"], "canonical_name": "transcription elongation from RNA polymerase III promoter", "definition": "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1158827", "aliases": ["transcription initiation from Pol III promoter"], "types": ["T045"], "canonical_name": "transcription initiation from RNA polymerase III promoter", "definition": "Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1158828", "aliases": ["transcription termination from Pol III promoter", "RNA polymerase III transcription termination", "transcription termination from RNA polymerase III promoter"], "types": ["T045"], "canonical_name": "termination of RNA polymerase III transcription", "definition": "The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues. [GOC:mah, PMID:12944462]"}
{"concept_id": "C1158829", "aliases": [], "types": ["T045"], "canonical_name": "tRNA transcription", "definition": "The synthesis of transfer RNA (tRNA) from a DNA template. [GOC:jl]"}
{"concept_id": "C1158831", "aliases": ["one-carbon metabolism", "one-carbon transfer metabolic process", "one carbon metabolic process", "one-carbon transfer metabolism", "one carbon metabolism"], "types": ["T044"], "canonical_name": "one-carbon metabolic process", "definition": "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde]"}
{"concept_id": "C1158832", "aliases": ["formate metabolism"], "types": ["T044"], "canonical_name": "formate metabolic process", "definition": "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. [ISBN:0198506732]"}
{"concept_id": "C1158833", "aliases": ["formic acid oxidation"], "types": ["T044"], "canonical_name": "formate oxidation", "definition": "The chemical reactions and pathways by which formate is converted to CO2. [MetaCyc:PWY-1881]"}
{"concept_id": "C1158834", "aliases": ["methane metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. [ISBN:0198506732]", "canonical_name": "methane metabolism"}
{"concept_id": "C1158835", "aliases": ["photorespiratory pathway"], "types": ["T044"], "canonical_name": "photorespiration", "definition": "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. [ISBN:0198506732]"}
{"concept_id": "C1158836", "aliases": [], "types": ["T044"], "canonical_name": "oxidative photosynthetic carbon pathway", "definition": "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2). [ISBN:0943088399]"}
{"concept_id": "C1158837", "aliases": [], "types": ["T044"], "canonical_name": "serine-isocitrate lyase pathway", "definition": "A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide. [ISBN:0387961534]"}
{"concept_id": "C1158838", "aliases": ["organic acid metabolism"], "types": ["T044"], "canonical_name": "organic acid metabolic process", "definition": "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. [ISBN:0198506732]"}
{"concept_id": "C1158839", "aliases": ["carboxylic acid metabolism"], "types": ["T044"], "canonical_name": "carboxylic acid metabolic process", "definition": "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). [ISBN:0198506732]"}
{"concept_id": "C1158840", "aliases": ["acetate metabolism"], "types": ["T044"], "canonical_name": "acetate metabolic process", "definition": "The chemical reactions and pathways involving acetate, the anion of acetic acid. [GOC:go_curators]"}
{"concept_id": "C1158842", "aliases": ["polyketide metabolism"], "types": ["T044"], "canonical_name": "polyketide metabolic process", "definition": "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1158843", "aliases": ["acetyl-CoA formation from acetate", "acetyl-CoA anabolism from acetate", "acetyl-CoA synthesis from acetate"], "types": ["T044"], "canonical_name": "acetyl-CoA biosynthetic process from acetate", "definition": "The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate. [MetaCyc:ACETATEUTIL-PWY]"}
{"concept_id": "C1158844", "aliases": ["pyruvate anabolism from acetate", "pyruvate synthesis from acetate", "pyruvate formation from acetate"], "types": ["T044"], "canonical_name": "pyruvate biosynthetic process from acetate", "definition": "The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate. [GOC:go_curators]"}
{"concept_id": "C1158845", "aliases": ["aldaric acid metabolism"], "types": ["T044"], "canonical_name": "aldaric acid metabolic process", "definition": "The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. [ISBN:0198506732]"}
{"concept_id": "C1158846", "aliases": ["mucic acid metabolic process", "mucic acid metabolism", "galactarate metabolism"], "types": ["T044"], "canonical_name": "galactarate metabolic process", "definition": "The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose. [GOC:pr, ISBN:0198506732]"}
{"concept_id": "C1158847", "aliases": ["D-galactarate metabolic process"], "types": ["T044"], "canonical_name": "D-galactarate metabolism"}
{"concept_id": "C1158848", "aliases": ["glucarate metabolism"], "types": ["T044"], "canonical_name": "glucarate metabolic process", "definition": "The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate. [ISBN:0198506732]"}
{"concept_id": "C1158849", "aliases": ["butanoic acid metabolism", "butanoic acid metabolic process", "butyric acid metabolism", "butyric acid metabolic process", "butyrate metabolism"], "types": ["T044"], "canonical_name": "butyrate metabolic process", "definition": "The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid. [ISBN:0198506732]"}
{"concept_id": "C1158850", "aliases": ["chorismate metabolism"], "types": ["T044"], "canonical_name": "chorismate metabolic process", "definition": "The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. [ISBN:0198506732]"}
{"concept_id": "C1158851", "aliases": ["galactonate metabolism"], "types": ["T044"], "canonical_name": "galactonate metabolic process", "definition": "The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose. [GOC:ai]"}
{"concept_id": "C1158852", "aliases": ["glycolate metabolism"], "types": ["T044"], "canonical_name": "glycolate metabolic process", "definition": "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid). [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1158853", "aliases": ["KDO metabolism", "ketodeoxyoctanoate metabolic process", "keto-3-deoxy-D-manno-octulosonic acid metabolism", "KDO metabolic process"], "types": ["T044"], "canonical_name": "keto-3-deoxy-D-manno-octulosonic acid metabolic process", "definition": "The chemical reactions and pathways involving keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1158854", "aliases": ["L-ascorbic acid metabolism", "vitamin C metabolic process", "ascorbate metabolism", "vitamin C metabolism", "ascorbate metabolic process"], "types": ["T044"], "canonical_name": "L-ascorbic acid metabolic process", "definition": "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1158855", "aliases": ["lactate metabolism", "2-hydroxypropanoate metabolic process", "alpha-hydroxypropionate metabolic process", "alpha-hydroxypropionate metabolism", "2-hydroxypropanoate metabolism"], "types": ["T044"], "canonical_name": "lactate metabolic process", "definition": "The chemical reactions and pathways involving lactate, the anion of lactic acid. [ISBN:0198547684]"}
{"concept_id": "C1158856", "aliases": [], "types": ["T044"], "canonical_name": "lactate oxidation", "definition": "The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons. [GOC:mah]"}
{"concept_id": "C1158857", "aliases": [], "types": ["T044"], "canonical_name": "lactate racemization", "definition": "Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture. [GOC:curators, PMID:16166538]"}
{"concept_id": "C1158859", "aliases": ["propionate metabolism, methylcitrate cycle"], "types": ["T044"], "canonical_name": "propionate metabolic process, methylcitrate cycle", "definition": "The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle. [GOC:go_curators]"}
{"concept_id": "C1158860", "aliases": ["propionate metabolism, methylmalonyl pathway"], "types": ["T044"], "canonical_name": "propionate metabolic process, methylmalonyl pathway", "definition": "The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway. [GOC:go_curators]"}
{"concept_id": "C1158861", "aliases": ["pyruvate metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. [GOC:go_curators]", "canonical_name": "pyruvate metabolism"}
{"concept_id": "C1158862", "aliases": [], "types": ["T044"], "canonical_name": "pyruvate oxidation", "definition": "The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate. [MetaCyc:PYRUVOX-PWY]"}
{"concept_id": "C1158863", "aliases": ["quinic acid metabolic process", "quinic acid metabolism", "quinate metabolism"], "types": ["T044"], "canonical_name": "quinate metabolic process", "definition": "The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1158864", "aliases": ["shikimate metabolism"], "types": ["T044"], "canonical_name": "shikimate metabolic process", "definition": "The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids. [GOC:sm, ISBN:0198547684]"}
{"concept_id": "C1158865", "aliases": ["teichoic acid metabolism"], "types": ["T044"], "canonical_name": "teichoic acid metabolic process", "definition": "The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. [ISBN:0198506732]"}
{"concept_id": "C1158866", "aliases": ["uronic acid metabolism"], "types": ["T044"], "canonical_name": "uronic acid metabolic process", "definition": "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. [ISBN:0198506732]"}
{"concept_id": "C1158867", "aliases": ["galacturonate metabolism"], "types": ["T044"], "canonical_name": "galacturonate metabolic process", "definition": "The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. [ISBN:0198506732]"}
{"concept_id": "C1158868", "aliases": ["D-galacturonate metabolism"], "types": ["T044"], "canonical_name": "D-galacturonate metabolic process", "definition": "The chemical reactions and pathways involving D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls. [GOC:ai, GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1158869", "aliases": ["glucuronate metabolism"], "types": ["T044"], "canonical_name": "glucuronate metabolic process", "definition": "The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158870", "aliases": ["UDP-glucuronate metabolism"], "types": ["T044"], "canonical_name": "UDP-glucuronate metabolic process", "definition": "The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C1158871", "aliases": [], "types": ["T044"], "canonical_name": "pyruvate dehydrogenase bypass"}
{"concept_id": "C1158872", "aliases": ["organometal metabolism"], "types": ["T044"], "canonical_name": "organometal metabolic process", "definition": "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms. [ISBN:0198506732]"}
{"concept_id": "C1158873", "aliases": ["organomercury metabolism"], "types": ["T044"], "canonical_name": "organomercury metabolic process", "definition": "The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom. [ISBN:0198506732]"}
{"concept_id": "C1158874", "aliases": ["methylmercury metabolism"], "types": ["T044"], "canonical_name": "methylmercury metabolic process", "definition": "The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species. [GOC:ai]"}
{"concept_id": "C1158875", "aliases": ["organotin metabolism"], "types": ["T044"], "canonical_name": "organotin metabolic process", "definition": "The chemical reactions and pathways involving organotin, an organic compound containing a tin atom. [ISBN:0198506732]"}
{"concept_id": "C1158876", "aliases": ["tri-n-butyltin metabolism"], "types": ["T044"], "canonical_name": "tri-n-butyltin metabolic process", "definition": "The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms. [GOC:ai, UM-BBD_pathwayID:tbt]"}
{"concept_id": "C1158880", "aliases": ["superoxide free radical metabolic process", "oxygen free radical metabolism", "superoxide metabolism", "superoxide free radical metabolism", "oxygen free radical metabolic process"], "types": ["T044"], "canonical_name": "superoxide metabolic process", "definition": "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. [GOC:jl]"}
{"concept_id": "C1158881", "aliases": ["cellular detoxification of superoxide radicals", "removal of O2-", "removal of oxygen free radicals"], "types": ["T044"], "canonical_name": "removal of superoxide radicals", "definition": "Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). [GOC:jl]"}
{"concept_id": "C1158882", "aliases": ["superoxide release"], "types": ["T044"], "canonical_name": "superoxide anion generation", "definition": "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. [GOC:jl, PMID:12359750]"}
{"concept_id": "C1158883", "aliases": ["phosphate metabolism", "phosphate metabolic process"], "types": ["T044"], "canonical_name": "phosphate-containing compound metabolic process", "definition": "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. [GOC:ai]"}
{"concept_id": "C1158884", "aliases": ["protein amino acid dephosphorylation"], "types": ["T044"], "definition": "The process of removing one or more phosphoric residues from a protein. [GOC:hb]", "canonical_name": "protein dephosphorylation"}
{"concept_id": "C1158886", "aliases": ["protein phosphorylation"], "types": ["T044"], "definition": "Protein phosphorylation is one of various post-translational protein modifications that regulates protein function and enzymatic activity. The major phosphoryl acceptors in proteins are serine, threonine, and tyrosine.", "canonical_name": "protein amino acid phosphorylation"}
{"concept_id": "C1158887", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine phosphorylation", "definition": "The phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine. [RESID:AA0222]"}
{"concept_id": "C1158888", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-aspartic acid phosphorylation", "definition": "The phosphorylation of peptidyl-aspartic acid. [GOC:jl]"}
{"concept_id": "C1158890", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine phosphorylation", "definition": "The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). [RESID:AA0035, RESID:AA0036]"}
{"concept_id": "C1158891", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine phosphorylation", "definition": "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]"}
{"concept_id": "C1158892", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine phosphorylation", "definition": "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [RESID:AA0038]"}
{"concept_id": "C1158893", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tyrosine phosphorylation", "definition": "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039]"}
{"concept_id": "C1158894", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein kinase activity", "definition": "Any process that modulates the frequency, rate or extent of protein kinase activity. [GOC:go_curators]"}
{"concept_id": "C1158895", "aliases": ["down regulation of protein kinase activity", "downregulation of protein kinase activity", "down-regulation of protein kinase activity"], "types": ["T043"], "canonical_name": "negative regulation of protein kinase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. [GOC:go_curators]"}
{"concept_id": "C1158896", "aliases": ["upregulation of protein kinase activity", "up-regulation of protein kinase activity", "up regulation of protein kinase activity"], "types": ["T043"], "canonical_name": "positive regulation of protein kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of protein kinase activity. [GOC:go_curators]"}
{"concept_id": "C1158897", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. [GOC:jl]"}
{"concept_id": "C1158898", "aliases": ["downregulation of phosphorylation", "down-regulation of phosphorylation", "down regulation of phosphorylation"], "types": ["T043"], "canonical_name": "negative regulation of phosphorylation", "definition": "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. [GOC:jl]"}
{"concept_id": "C1158899", "aliases": ["up-regulation of phosphorylation", "up regulation of phosphorylation", "upregulation of phosphorylation"], "types": ["T043"], "canonical_name": "positive regulation of phosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. [GOC:jl]"}
{"concept_id": "C1158900", "aliases": ["polyphosphate metabolism"], "types": ["T044"], "canonical_name": "polyphosphate metabolic process", "definition": "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158901", "aliases": ["regulation of phosphate metabolism"], "types": ["T043"], "canonical_name": "regulation of phosphate metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates. [GOC:go_curators]"}
{"concept_id": "C1158902", "aliases": ["down-regulation of phosphate metabolic process", "negative regulation of phosphate metabolism", "down regulation of phosphate metabolic process", "downregulation of phosphate metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of phosphate metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. [GOC:go_curators]"}
{"concept_id": "C1158903", "aliases": ["down regulation of phosphorus utilization", "downregulation of phosphorus utilization", "down-regulation of phosphorus utilization"], "types": ["T043"], "canonical_name": "negative regulation of phosphorus utilization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphorus utilization. [GOC:go_curators]"}
{"concept_id": "C1158904", "aliases": ["up regulation of phosphate metabolic process", "up-regulation of phosphate metabolic process", "positive regulation of phosphate metabolism", "upregulation of phosphate metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of phosphate metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. [GOC:go_curators]"}
{"concept_id": "C1158905", "aliases": ["up regulation of phosphorus utilization", "upregulation of phosphorus utilization", "up-regulation of phosphorus utilization"], "types": ["T043"], "canonical_name": "positive regulation of phosphorus utilization", "definition": "Any process that activates or increases the frequency, rate or extent of phosphorus utilization. [GOC:go_curators]"}
{"concept_id": "C1158906", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phosphorus utilization", "definition": "Any process that modulates the frequency, rate or extent of phosphorus utilization. [GOC:go_curators]"}
{"concept_id": "C1158907", "aliases": [], "types": ["T043"], "canonical_name": "phosphorus utilization", "definition": "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism. [GOC:mah, GOC:mlg]"}
{"concept_id": "C1158908", "aliases": ["pigment metabolism"], "types": ["T043"], "canonical_name": "pigment metabolic process", "definition": "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1158909", "aliases": ["eye pigment metabolism"], "types": ["T043"], "canonical_name": "eye pigment metabolic process", "definition": "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. [GOC:ai]"}
{"concept_id": "C1158910", "aliases": [], "types": ["T043"], "canonical_name": "eye pigment precursor transport", "definition": "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1158911", "aliases": ["rhodopsin metabolism"], "types": ["T044"], "canonical_name": "rhodopsin metabolic process", "definition": "The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. [ISBN:0198506732]"}
{"concept_id": "C1158912", "aliases": ["melanin metabolism"], "types": ["T044"], "canonical_name": "melanin metabolic process", "definition": "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. [GOC:go_curators]"}
{"concept_id": "C1158913", "aliases": ["ocellus pigment metabolism"], "types": ["T044"], "canonical_name": "ocellus pigment metabolic process", "definition": "The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. [GOC:ai, PMID:15176085, PMID:18421706]"}
{"concept_id": "C1158914", "aliases": ["glycoprotein metabolism"], "types": ["T044"], "canonical_name": "glycoprotein metabolic process", "definition": "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1158915", "aliases": ["haemoglobin metabolic process", "haemoglobin metabolism", "hemoglobin metabolism"], "types": ["T044"], "canonical_name": "hemoglobin metabolic process", "definition": "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. [GOC:go_curators, GOC:jl]"}
{"concept_id": "C1158916", "aliases": ["hemoglobin uptake", "haemoglobin uptake", "endocytic hemoglobin import"], "types": ["T043"], "canonical_name": "endocytic hemoglobin import into cell", "definition": "The directed movement of hemoglobin into a cell by receptor-mediated endocytosis. [GOC:mb]"}
{"concept_id": "C1158917", "aliases": ["lipoprotein metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. [ISBN:0198506732]", "canonical_name": "lipoprotein metabolism"}
{"concept_id": "C1158918", "aliases": [], "types": ["T044"], "canonical_name": "lipoprotein modification", "definition": "The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. [GOC:mah]"}
{"concept_id": "C1158919", "aliases": [], "types": ["T044"], "definition": "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group. [GOC:mah]", "canonical_name": "lipoprotein oxidation"}
{"concept_id": "C1158920", "aliases": ["mannoprotein metabolism"], "types": ["T044"], "canonical_name": "mannoprotein metabolic process", "definition": "The chemical reactions and pathways involving a mannoprotein, a protein that contains covalently bound mannose residues. [ISBN:0198506732]"}
{"concept_id": "C1158921", "aliases": ["peptide metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:go_curators]", "canonical_name": "peptide metabolism"}
{"concept_id": "C1158922", "aliases": [], "types": ["T044"], "canonical_name": "peptide amidation", "definition": "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions. [PMID:11028916]"}
{"concept_id": "C1158924", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome biogenesis"}
{"concept_id": "C1158925", "aliases": ["coenzyme Q and cytochrome c reductase complex biogenesis", "cytochrome bc(1) complex assembly", "coenzyme Q and cytochrome c reductase complex assembly", "complex III assembly", "complex III biogenesis", "cytochrome bc(1) complex biogenesis"], "types": ["T044"], "canonical_name": "respiratory chain complex III assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents. [GOC:jl, http://www.brainyencyclopedia.com/]"}
{"concept_id": "C1158926", "aliases": ["cytochrome c-haem linkage"], "types": ["T044"], "canonical_name": "cytochrome c-heme linkage", "definition": "The linkage of cytochromes and other heme proteins to heme. [RESID:AA0134, RESID:AA0135]"}
{"concept_id": "C1158927", "aliases": ["cytochrome c-haem linkage via haem-bis-L-cysteine"], "types": ["T044"], "canonical_name": "cytochrome c-heme linkage via heme-bis-L-cysteine", "definition": "The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine. [RESID:AA0134]"}
{"concept_id": "C1158928", "aliases": ["cytochrome c-haem linkage via haem-L-cysteine"], "types": ["T044"], "canonical_name": "cytochrome c-heme linkage via heme-L-cysteine", "definition": "The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine. [RESID:AA0135]"}
{"concept_id": "C1158929", "aliases": ["cytochrome P450 4A1-haem linkage"], "types": ["T044"], "canonical_name": "cytochrome P450 4A1-heme linkage", "definition": "The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester. [GOC:cjm, RESID:AA0324]"}
{"concept_id": "C1158930", "aliases": ["peroxidase-haem linkage"], "types": ["T044"], "canonical_name": "peroxidase-heme linkage", "definition": "The covalent linkage of heme to peroxidase. [RESID:AA0279, RESID:AA0280]"}
{"concept_id": "C1158931", "aliases": ["peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester"], "types": ["T044"], "canonical_name": "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester", "definition": "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester. [RESID:AA0279]"}
{"concept_id": "C1158932", "aliases": ["peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium", "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium"], "types": ["T044"], "canonical_name": "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium", "definition": "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium. [RESID:AA0280]"}
{"concept_id": "C1158933", "aliases": ["protein-haem linkage via 1'-L-histidine"], "types": ["T044"], "canonical_name": "protein-heme linkage via 1'-L-histidine", "definition": "The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine). [RESID:AA0329]"}
{"concept_id": "C1158934", "aliases": ["protein-haem P460 linkage"], "types": ["T044"], "canonical_name": "protein-heme P460 linkage", "definition": "The linkage of protein to heme P460. [RESID:AA0266, RESID:AA0271]"}
{"concept_id": "C1158935", "aliases": ["protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine"], "types": ["T044"], "canonical_name": "protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine", "definition": "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine. [RESID:AA0271]"}
{"concept_id": "C1158936", "aliases": ["protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine"], "types": ["T044"], "canonical_name": "protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine", "definition": "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine. [RESID:AA0266]"}
{"concept_id": "C1158937", "aliases": [], "types": ["T044"], "canonical_name": "protein catenane formation", "definition": "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain. [ISBN:0198506732]"}
{"concept_id": "C1158938", "aliases": [], "types": ["T044"], "canonical_name": "protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic", "definition": "The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid. [RESID:AA0294]"}
{"concept_id": "C1158939", "aliases": ["protein complex assembly, multichaperone pathway", "cellular chaperone-mediated protein complex assembly"], "types": ["T044"], "canonical_name": "chaperone-mediated protein complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. [GOC:ai]"}
{"concept_id": "C1158940", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome c oxidase biogenesis"}
{"concept_id": "C1158941", "aliases": [], "types": ["T044"], "canonical_name": "steroid hormone receptor complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor. [GOC:jl, Wikipedia:Steroid_hormone_receptor]"}
{"concept_id": "C1158942", "aliases": ["nascent chain protein folding"], "types": ["T044"], "canonical_name": "'de novo' protein folding", "definition": "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. [GOC:mb]"}
{"concept_id": "C1158944", "aliases": [], "types": ["T044"], "definition": "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. [GOC:mb]", "canonical_name": "protein refolding"}
{"concept_id": "C1158946", "aliases": ["establishment and maintenance of protein localization in apical part of cell", "establishment and maintenance of apical protein localization", "apical protein localisation"], "types": ["T043"], "canonical_name": "apical protein localization", "definition": "Any process in which a protein is transported to, or maintained in, apical regions of the cell. [GOC:bf]"}
{"concept_id": "C1158947", "aliases": ["cell fate commitment, asymmetric protein localization", "asymmetric protein localisation involved in cell fate determination", "asymmetric protein localization involved in cell fate commitment", "asymmetric protein localization resulting in cell fate commitment"], "types": ["T043"], "canonical_name": "asymmetric protein localization involved in cell fate determination", "definition": "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types. [GOC:ai]"}
{"concept_id": "C1158948", "aliases": ["establishment and maintenance of protein localization in basal part of cell", "basal protein localisation", "establishment and maintenance of basal protein localization"], "types": ["T043"], "canonical_name": "basal protein localization", "definition": "Any process in which a protein is transported to, or maintained in, basal regions of the cell. [GOC:bf]"}
{"concept_id": "C1158949", "aliases": ["establishment and maintenance of pole plasm protein localization", "oocyte pole plasm protein localization", "pole plasm protein localisation"], "types": ["T043"], "canonical_name": "pole plasm protein localization", "definition": "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. [GOC:ai]"}
{"concept_id": "C1158950", "aliases": ["protein recruitment", "establishment of protein localisation", "protein positioning"], "types": ["T043"], "canonical_name": "establishment of protein localization", "definition": "The directed movement of a protein to a specific location. [GOC:bf]"}
{"concept_id": "C1158951", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of protein localization"}
{"concept_id": "C1158952", "aliases": ["localization of viral capsid precursors in nucleus", "establishment and maintenance of viral capsid precursor localization in nucleus", "viral capsid precursor localization in host cell nucleus", "nuclear localization of viral capsid precursors", "viral capsid precursor localisation in host cell nucleus", "viral capsid precursor localization to host cell nucleus"], "types": ["T043"], "canonical_name": "viral capsid precursor transport to host cell nucleus", "definition": "Any process in which viral capsid precursors are transported to a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid. [ISBN:0781718325]"}
{"concept_id": "C1158975", "aliases": [], "types": ["T044"], "canonical_name": "metal incorporation into metallo-molybdopterin complex", "definition": "The incorporation of a metal into a metallo-molybdopterin complex. [GOC:ai]"}
{"concept_id": "C1158977", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum incorporation via L-cysteinyl molybdopterin", "definition": "The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin. [RESID:AA0142]"}
{"concept_id": "C1158978", "aliases": [], "types": ["T044"], "canonical_name": "tungsten incorporation into tungsten-molybdopterin complex", "definition": "The incorporation of tungsten into a tungsten-molybdopterin complex. [GOC:ai]"}
{"concept_id": "C1158979", "aliases": ["metal incorporation into metallo-sulphur cluster"], "types": ["T044"], "canonical_name": "metal incorporation into metallo-sulfur cluster", "definition": "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide. [GOC:jsg]"}
{"concept_id": "C1158980", "aliases": ["copper incorporation into metallo-sulphur cluster"], "types": ["T044"], "canonical_name": "copper incorporation into metallo-sulfur cluster", "definition": "The incorporation of copper into a metallo-sulfur cluster. [GOC:ai]"}
{"concept_id": "C1158981", "aliases": ["copper incorporation into copper-sulphur cluster"], "types": ["T044"], "canonical_name": "copper incorporation into copper-sulfur cluster", "definition": "The incorporation of copper into a copper-sulfur cluster. [GOC:ai]"}
{"concept_id": "C1158982", "aliases": ["copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide"], "types": ["T044"], "canonical_name": "copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide", "definition": "The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide. [RESID:AA0298]"}
{"concept_id": "C1158983", "aliases": ["iron incorporation into metallo-sulphur cluster"], "types": ["T044"], "canonical_name": "iron incorporation into metallo-sulfur cluster", "definition": "The incorporation of iron into a metallo-sulfur cluster. [GOC:ai]"}
{"concept_id": "C1158984", "aliases": ["iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide", "definition": "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide. [RESID:AA0289]"}
{"concept_id": "C1158985", "aliases": ["iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide", "definition": "The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase. [PMID:9063865, RESID:AA0300]"}
{"concept_id": "C1158986", "aliases": ["iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide", "definition": "The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase. [RESID:AA0310]"}
{"concept_id": "C1158987", "aliases": ["iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide", "definition": "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide. [RESID:AA0137]"}
{"concept_id": "C1158988", "aliases": ["iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide", "definition": "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide. [RESID:AA0140]"}
{"concept_id": "C1158989", "aliases": ["iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide", "definition": "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide. [PMID:11592901, RESID:AA0326]"}
{"concept_id": "C1158990", "aliases": ["iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide", "definition": "The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. [RESID:AA0292]"}
{"concept_id": "C1158991", "aliases": ["iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide", "definition": "The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. [RESID:AA0293]"}
{"concept_id": "C1158992", "aliases": ["iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide", "definition": "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide. [RESID:AA0139]"}
{"concept_id": "C1158993", "aliases": ["iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide", "definition": "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide. [RESID:AA0286]"}
{"concept_id": "C1158994", "aliases": ["iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon", "definition": "The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon. [RESID:AA0268]"}
{"concept_id": "C1158995", "aliases": ["iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide", "definition": "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide. [RESID:AA0284]"}
{"concept_id": "C1158996", "aliases": ["iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide", "definition": "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide. [RESID:AA0285]"}
{"concept_id": "C1158997", "aliases": ["iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide", "definition": "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide. [RESID:AA0288]"}
{"concept_id": "C1158998", "aliases": [], "types": ["T044"], "canonical_name": "iron incorporation into protein via tetrakis-L-cysteinyl iron", "definition": "The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein). [RESID:AA0136]"}
{"concept_id": "C1158999", "aliases": ["iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide"], "types": ["T044"], "canonical_name": "iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide", "definition": "The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide. [RESID:AA0225]"}
{"concept_id": "C1159000", "aliases": ["molybdenum incorporation into metallo-sulphur cluster"], "types": ["T044"], "canonical_name": "molybdenum incorporation into metallo-sulfur cluster", "definition": "The incorporation of molybdenum into a metallo-sulfur cluster. [GOC:ai]"}
{"concept_id": "C1159001", "aliases": ["molybdenum incorporation into iron-sulphur cluster"], "types": ["T044"], "canonical_name": "molybdenum incorporation into iron-sulfur cluster", "definition": "The incorporation of molybdenum into an iron-sulfur cluster. [GOC:ai]"}
{"concept_id": "C1159002", "aliases": ["iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide"], "types": ["T044"], "canonical_name": "iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide", "definition": "The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase. [RESID:AA0141]"}
{"concept_id": "C1159003", "aliases": ["molybdenum incorporation into metallo-pterin complex"], "types": ["T044"], "canonical_name": "molybdenum incorporation into molybdenum-molybdopterin complex", "definition": "The incorporation of molybdenum into a molybdenum-molybdopterin complex. [GOC:ai]"}
{"concept_id": "C1159004", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide", "definition": "The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide. [RESID:AA0281]"}
{"concept_id": "C1159005", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)", "definition": "The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide). [RESID:AA0248]"}
{"concept_id": "C1159006", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide", "definition": "The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide. [PDB:1EU1, PMID:8658132, RESID:AA0319]"}
{"concept_id": "C1159007", "aliases": ["nickel incorporation into metallo-sulphur cluster"], "types": ["T044"], "canonical_name": "nickel incorporation into metallo-sulfur cluster", "definition": "The incorporation of nickel into a metallo-sulfur cluster. [GOC:ai]"}
{"concept_id": "C1159008", "aliases": ["nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide"], "types": ["T044"], "canonical_name": "nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide", "definition": "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. [RESID:AA0292]"}
{"concept_id": "C1159009", "aliases": ["nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide"], "types": ["T044"], "canonical_name": "nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide", "definition": "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. [RESID:AA0293]"}
{"concept_id": "C1159010", "aliases": ["nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide"], "types": ["T044"], "canonical_name": "nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide", "definition": "The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase. [RESID:AA0310]"}
{"concept_id": "C1159011", "aliases": ["vanadium incorporation into metallo-sulphur cluster"], "types": ["T044"], "canonical_name": "vanadium incorporation into metallo-sulfur cluster", "definition": "The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n). [PMID:11053414]"}
{"concept_id": "C1159012", "aliases": [], "types": ["T044"], "canonical_name": "nucleic acid-protein covalent cross-linking", "definition": "The formation of a covalent cross-link between a nucleic acid and a protein. [GOC:ma]"}
{"concept_id": "C1159013", "aliases": ["DNA-protein covalent cross-linking"], "types": ["T044"], "canonical_name": "protein-DNA covalent cross-linking", "definition": "The formation of a covalent cross-link between DNA and a protein. [GOC:ma]"}
{"concept_id": "C1159014", "aliases": ["DNA-protein covalent cross-linking via peptidyl-serine"], "types": ["T044"], "canonical_name": "protein-DNA covalent cross-linking via peptidyl-serine", "definition": "The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine. [RESID:AA0246]"}
{"concept_id": "C1159015", "aliases": ["DNA-protein covalent cross-linking via peptidyl-threonine"], "types": ["T044"], "canonical_name": "protein-DNA covalent cross-linking via peptidyl-threonine", "definition": "The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine. [RESID:AA0255]"}
{"concept_id": "C1159016", "aliases": ["DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine"], "types": ["T044"], "canonical_name": "protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine", "definition": "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine. [RESID:AA0254]"}
{"concept_id": "C1159017", "aliases": [], "types": ["T044"], "canonical_name": "RNA-protein covalent cross-linking", "definition": "The formation of a covalent cross-link between RNA and a protein. [GOC:ma]"}
{"concept_id": "C1159018", "aliases": [], "types": ["T044"], "canonical_name": "RNA-protein covalent cross-linking via peptidyl-serine", "definition": "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine. [RESID:AA0213]"}
{"concept_id": "C1159019", "aliases": [], "types": ["T044"], "canonical_name": "RNA-protein covalent cross-linking via peptidyl-tyrosine", "definition": "The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine. [RESID:AA0249]"}
{"concept_id": "C1159020", "aliases": ["peptide or protein amino-terminal blocking"], "types": ["T044"], "canonical_name": "peptide/protein amino-terminal blocking"}
{"concept_id": "C1159021", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine", "definition": "The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine. [RESID:AA0275]"}
{"concept_id": "C1159022", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid acetylation", "definition": "The acetylation of the N-terminal amino acid of proteins. [GOC:ai]"}
{"concept_id": "C1159023", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-alanine acetylation", "definition": "The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase. [RESID:AA0041]"}
{"concept_id": "C1159024", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-aspartic acid acetylation", "definition": "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase. [RESID:AA0042]"}
{"concept_id": "C1159025", "aliases": ["peptidyl-cysteine N-acetylation"], "types": ["T044"], "canonical_name": "N-terminal peptidyl-cysteine acetylation", "definition": "The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine. [RESID:AA0043]"}
{"concept_id": "C1159026", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glutamic acid acetylation", "definition": "The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid. [RESID:AA0044]"}
{"concept_id": "C1159027", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glutamine acetylation", "definition": "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable. [RESID:AA0045]"}
{"concept_id": "C1159028", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glycine acetylation", "definition": "The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine. [RESID:AA0046]"}
{"concept_id": "C1159029", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-isoleucine acetylation", "definition": "The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed. [RESID:AA0047]"}
{"concept_id": "C1159030", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-lysine acetylation", "definition": "The acetylation of the N-terminal lysine of proteins. [GOC:ai]"}
{"concept_id": "C1159031", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-lysine N2-acetylation", "definition": "The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed. [RESID:AA0048]"}
{"concept_id": "C1159032", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-methionine acetylation", "definition": "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine. [RESID:AA0049]"}
{"concept_id": "C1159033", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-proline acetylation", "definition": "The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline. [RESID:AA0050]"}
{"concept_id": "C1159034", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-serine acetylation", "definition": "The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine. [RESID:AA0051]"}
{"concept_id": "C1159035", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-threonine acetylation", "definition": "The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase. [RESID:AA0052]"}
{"concept_id": "C1159036", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-tyrosine acetylation", "definition": "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine. [RESID:AA0053]"}
{"concept_id": "C1159037", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-valine acetylation", "definition": "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine. [RESID:AA0054]"}
{"concept_id": "C1159038", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid deamination", "definition": "The removal of an amino group from the N-terminal amino acid residue of a protein. [GOC:mah]"}
{"concept_id": "C1159040", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-amino acid deamination to pyruvic acid", "definition": "The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. [RESID:AA0127]"}
{"concept_id": "C1159041", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine", "definition": "The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine. [RESID:AA0274]"}
{"concept_id": "C1159042", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-serine deamination", "definition": "The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. [RESID:AA0127]"}
{"concept_id": "C1159043", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-threonine deamination", "definition": "The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid. [RESID:AA0129]"}
{"concept_id": "C1159044", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-valine deamination", "definition": "The deamination of the N-terminal valine residue of a protein to form isobutyrate. [GOC:ma, GOC:mah]"}
{"concept_id": "C1159045", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid methylation", "definition": "The methylation of the N-terminal amino acid of a protein. [GOC:ai]"}
{"concept_id": "C1159046", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-alanine methylation", "definition": "The methylation of the N-terminal alanine of proteins. [RESID:AA0061, RESID:AA0062]"}
{"concept_id": "C1159049", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glutamine methylation", "definition": "The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative. [RESID:AA0071]"}
{"concept_id": "C1159050", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glycine methylation", "definition": "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine. [RESID:AA0063]"}
{"concept_id": "C1159051", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-methionine methylation", "definition": "The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine. [RESID:AA0064]"}
{"concept_id": "C1159052", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-phenylalanine methylation", "definition": "The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine. [RESID:AA0065]"}
{"concept_id": "C1159054", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein formylation", "definition": "The formylation of the N-terminal amino acid of proteins. [GOC:ai]"}
{"concept_id": "C1159055", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glycine N-formylation", "definition": "The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine. [RESID:AA0057]"}
{"concept_id": "C1159056", "aliases": ["peptide or protein carboxyl-terminal blocking"], "types": ["T044"], "canonical_name": "peptide/protein carboxyl-terminal blocking"}
{"concept_id": "C1159057", "aliases": ["C-terminal protein amino acid methylation"], "types": ["T044"], "canonical_name": "C-terminal protein methylation", "definition": "The methylation of the C-terminal amino acid of a protein. [GOC:ai]"}
{"concept_id": "C1159082", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-amino acid modification", "definition": "The alteration of an amino acid residue in a peptide. [GOC:mah]"}
{"concept_id": "C1159083", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-alanine modification", "definition": "The modification of peptidyl-alanine. [GOC:go_curators]"}
{"concept_id": "C1159084", "aliases": ["peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine", "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine", "peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine"], "types": ["T044"], "canonical_name": "peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine", "definition": "The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG. [RESID:AA0181]"}
{"concept_id": "C1159085", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-alanyl-5-imidazolinone glycine", "definition": "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water. [RESID:AA0187]"}
{"concept_id": "C1159086", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine modification", "definition": "The modification of peptidyl-arginine. [GOC:go_curators]"}
{"concept_id": "C1159087", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine ADP-ribosylation", "definition": "The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine. [RESID:AA0168]"}
{"concept_id": "C1159088", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine hydroxylation", "definition": "The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine. [GOC:mah]"}
{"concept_id": "C1159089", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine methylation", "definition": "The addition of a methyl group to an arginine residue in a protein. [GOC:mah]"}
{"concept_id": "C1159090", "aliases": ["peptidyl-arginine 5-methylation"], "types": ["T044"], "canonical_name": "peptidyl-arginine C5-methylation", "definition": "The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine. [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272]"}
{"concept_id": "C1159091", "aliases": ["peptidyl-arginine delta-N-methylation"], "types": ["T044"], "canonical_name": "peptidyl-arginine N5-methylation", "definition": "The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine. [GOC:bf, PMID:9792625, RESID:AA0305]"}
{"concept_id": "C1159092", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine methylation, to symmetrical-dimethyl arginine", "definition": "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine. [RESID:AA0067, RESID:AA0069]"}
{"concept_id": "C1159093", "aliases": ["peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine"], "types": ["T044"], "canonical_name": "peptidyl-arginine methylation, to asymmetrical-dimethyl arginine", "definition": "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine. [RESID:AA0068, RESID:AA0069]"}
{"concept_id": "C1159094", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-asparagine modification", "definition": "The modification of peptidyl-asparagine. [GOC:go_curators]"}
{"concept_id": "C1159095", "aliases": [], "types": ["T044"], "canonical_name": "isopeptide cross-linking via N-(L-isoaspartyl)-glycine", "definition": "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine. [RESID:AA0126]"}
{"concept_id": "C1159096", "aliases": [], "types": ["T044"], "canonical_name": "isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine", "definition": "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine. [RESID:AA0216]"}
{"concept_id": "C1159097", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-asparagine ADP-ribosylation", "definition": "The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine. [RESID:AA0231]"}
{"concept_id": "C1159098", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-asparagine hydroxylation", "definition": "The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine. [GOC:mah]"}
{"concept_id": "C1159099", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine", "definition": "The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16). [RESID:AA0026]"}
{"concept_id": "C1159100", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-asparagine methylation", "definition": "The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine. [RESID:AA0070, RESID:AA0311]"}
{"concept_id": "C1159101", "aliases": ["peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine", "peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine", "peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine"], "types": ["T044"], "canonical_name": "peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine", "definition": "The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12. [GOC:jsg, RESID:AA0320]"}
{"concept_id": "C1159102", "aliases": ["peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine", "peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine", "peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine"], "types": ["T044"], "canonical_name": "peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine", "definition": "The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine. [RESID:AA0236]"}
{"concept_id": "C1159103", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via N6-(L-isoaspartyl)-L-lysine", "definition": "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues. [RESID:AA0294]"}
{"concept_id": "C1159104", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic", "definition": "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions. [RESID:AA0294]"}
{"concept_id": "C1159105", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-aspartic acid modification", "definition": "The modification of peptidyl-aspartic acid. [GOC:ma]"}
{"concept_id": "C1159106", "aliases": ["cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid", "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid", "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid"], "types": ["T044"], "canonical_name": "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid", "definition": "The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1. [RESID:AA0316]"}
{"concept_id": "C1159107", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-aspartic acid carboxylation", "definition": "The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid. [RESID:AA0304]"}
{"concept_id": "C1159108", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-aspartic acid hydroxylation", "definition": "The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid. [GOC:mah]"}
{"concept_id": "C1159109", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid", "definition": "The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16). [RESID:AA0027]"}
{"concept_id": "C1159110", "aliases": ["peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid", "peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid", "peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid"], "types": ["T044"], "canonical_name": "peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid", "definition": "The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid. [GOC:go_curators]"}
{"concept_id": "C1159111", "aliases": ["peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid", "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid", "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid", "peptidyl-aspartic acid methylthiolation"], "types": ["T044"], "canonical_name": "peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid", "definition": "The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12. [RESID:AA0232]"}
{"concept_id": "C1159112", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine modification", "definition": "The modification of peptidyl-cysteine. [GOC:go_curators]"}
{"concept_id": "C1159113", "aliases": ["biosynthesis of protein-protein cross-link via 5-imidazolinone glycine", "biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine"], "types": ["T044"], "canonical_name": "peptide cross-linking via 5-imidazolinone glycine", "definition": "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde. [RESID:AA0184, RESID:AA0187, RESID:AA0188]"}
{"concept_id": "C1159114", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme A-peptidyl-cysteine covalent linking", "definition": "The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide. [RESID:AA0306]"}
{"concept_id": "C1159115", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine acetylation", "definition": "The acetylation of peptidyl-cysteine. [GOC:mah]"}
{"concept_id": "C1159116", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine S-acetylation", "definition": "The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine. [RESID:AA0056]"}
{"concept_id": "C1159117", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine ADP-ribosylation", "definition": "The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine. [RESID:AA0169]"}
{"concept_id": "C1159118", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine esterification", "definition": "The addition of an ester group to a cysteine residue in a protein. [GOC:mah]"}
{"concept_id": "C1159119", "aliases": ["peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine", "peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine", "peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine", "definition": "The modification of a C-terminal peptidyl-cysteine to form peptidyl-L-cysteine methyl ester. [RESID:AA0105]"}
{"concept_id": "C1159120", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine methylation", "definition": "The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine. [RESID:AA0234]"}
{"concept_id": "C1159121", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine oxidation", "definition": "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid. [PMID:9586994, RESID:AA0205, RESID:AA0262]"}
{"concept_id": "C1159122", "aliases": [], "types": ["T044"], "canonical_name": "protein cysteine-thiol oxidation", "definition": "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine. [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025]"}
{"concept_id": "C1159123", "aliases": ["protein S-nitrosylation", "peptidyl-cysteine S-nitrosylation"], "types": ["T044"], "definition": "The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine. [RESID:AA0230]", "canonical_name": "S-nitrosylation"}
{"concept_id": "C1159124", "aliases": ["peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine", "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine", "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine"], "types": ["T044"], "canonical_name": "peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine", "definition": "The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases. [RESID:AA0185]"}
{"concept_id": "C1159125", "aliases": ["peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine", "peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine", "peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine", "peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine", "peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine", "definition": "The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide. [RESID:AA0229]"}
{"concept_id": "C1159126", "aliases": ["peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine", "peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine", "peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine", "peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine", "peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine", "definition": "The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide. [RESID:AA0101]"}
{"concept_id": "C1159128", "aliases": ["peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine", "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine", "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine", "definition": "The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids. [RESID:AA0107]"}
{"concept_id": "C1159129", "aliases": ["peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine", "peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine", "peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine", "definition": "The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine. [PMID:7797461, RESID:AA0223]"}
{"concept_id": "C1159133", "aliases": [], "types": ["T044"], "canonical_name": "protein-FAD linkage via S-(8alpha-FAD)-L-cysteine", "definition": "The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine. [RESID:AA0143]"}
{"concept_id": "C1159134", "aliases": [], "types": ["T044"], "canonical_name": "protein-FMN linkage via S-(6-FMN)-L-cysteine", "definition": "The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine. [RESID:AA0220]"}
{"concept_id": "C1159135", "aliases": [], "types": ["T044"], "canonical_name": "protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine", "definition": "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine. [RESID:AA0131]"}
{"concept_id": "C1159136", "aliases": [], "types": ["T044"], "canonical_name": "protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine", "definition": "The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine. [RESID:AA0259]"}
{"concept_id": "C1159137", "aliases": [], "types": ["T044"], "canonical_name": "protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine", "definition": "The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine. [RESID:AA0132]"}
{"concept_id": "C1159138", "aliases": [], "types": ["T044"], "canonical_name": "protein-phycourobilin linkage via phycourobilin-bis-L-cysteine", "definition": "The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine. [RESID:AA0260]"}
{"concept_id": "C1159139", "aliases": [], "types": ["T044"], "canonical_name": "protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine", "definition": "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine. [RESID:AA0133]"}
{"concept_id": "C1159140", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via (2R,6R)-lanthionine", "definition": "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine). [RESID:AA0110]"}
{"concept_id": "C1159141", "aliases": ["peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide"], "types": ["T044"], "canonical_name": "peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide", "definition": "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine. [RESID:AA0330]"}
{"concept_id": "C1159142", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine", "definition": "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine). [RESID:AA0112]"}
{"concept_id": "C1159143", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine", "definition": "The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link. [RESID:AA0109]"}
{"concept_id": "C1159144", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine", "definition": "The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase. [RESID:AA0113]"}
{"concept_id": "C1159145", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid", "definition": "The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid. [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0314]"}
{"concept_id": "C1159146", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone", "definition": "The cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase. [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0313]"}
{"concept_id": "C1159147", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid", "definition": "The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid. [RESID:AA0315]"}
{"concept_id": "C1159148", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine", "definition": "The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine. [RESID:AA0253]"}
{"concept_id": "C1159149", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via S-(2-aminovinyl)-D-cysteine", "definition": "The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine. [RESID:AA0204]"}
{"concept_id": "C1159150", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via S-(L-isoglutamyl)-L-cysteine", "definition": "The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link. [RESID:AA0108]"}
{"concept_id": "C1159151", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via S-glycyl-L-cysteine", "definition": "The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins. [GOC:jh2, RESID:AA0206]"}
{"concept_id": "C1159152", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via sn-(2S,6R)-lanthionine", "definition": "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione). [RESID:AA0111]"}
{"concept_id": "C1159153", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamic acid modification", "definition": "The modification of peptidyl-glutamic acid. [GOC:go_curators]"}
{"concept_id": "C1159154", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamic acid carboxylation", "definition": "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. [RESID:AA0032]"}
{"concept_id": "C1159155", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamic acid esterification", "definition": "The addition of an ester group to a glutamic acid residue in a protein. [GOC:mah]"}
{"concept_id": "C1159156", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamine esterification", "definition": "The addition of an ester group to a glutamine residue in a protein. [GOC:mah]"}
{"concept_id": "C1159157", "aliases": ["peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine", "peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine", "peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine"], "types": ["T044"], "canonical_name": "peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine", "definition": "The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester. [RESID:AA0072]"}
{"concept_id": "C1159158", "aliases": ["peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid", "peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid", "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid"], "types": ["T044"], "canonical_name": "peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid", "definition": "The methyl esterification of peptidyl-glutamic acid. [RESID:AA0072]"}
{"concept_id": "C1159159", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamic acid poly-ADP-ribosylation", "definition": "This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way. [RESID:AA0295]"}
{"concept_id": "C1159160", "aliases": ["peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid", "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid", "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid"], "types": ["T044"], "canonical_name": "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid", "definition": "The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit. [PMID:2569467, RESID:AA0170]"}
{"concept_id": "C1159161", "aliases": [], "types": ["T044"], "canonical_name": "protein polyglutamylation", "definition": "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid. [RESID:AA0202]"}
{"concept_id": "C1159162", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamine modification", "definition": "The modification of peptidyl-glutamine. [GOC:go_curators]"}
{"concept_id": "C1159163", "aliases": [], "types": ["T044"], "canonical_name": "isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine", "definition": "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine. [RESID:AA0124]"}
{"concept_id": "C1159164", "aliases": ["2-pyrrolidone-5-carboxylic acid biosynthesis", "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase", "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase", "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase", "2-pyrrolidone-5-carboxylic acid biosynthetic process"], "types": ["T044"], "canonical_name": "peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase", "definition": "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase. [RESID:AA0031]"}
{"concept_id": "C1159165", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glycine modification", "definition": "The modification of peptidyl-glycine. [GOC:go_curators]"}
{"concept_id": "C1159168", "aliases": [], "types": ["T044"], "canonical_name": "isopeptide cross-linking via N6-glycyl-L-lysine", "definition": "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination. [RESID:AA0125]"}
{"concept_id": "C1159169", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-sarcosine incorporation", "definition": "The incorporation of sarcosine (N-methylglycine) into non-coded peptides. [RESID:AA0063]"}
{"concept_id": "C1159170", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine modification", "definition": "The modification of peptidyl-histidine. [GOC:ma]"}
{"concept_id": "C1159171", "aliases": ["peptidyl-diphthamide metabolism"], "types": ["T044"], "canonical_name": "peptidyl-diphthamide metabolic process", "definition": "The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue. [GOC:go_curators]"}
{"concept_id": "C1159172", "aliases": ["peptidyl-diphthamide formation from peptidyl-histidine", "peptidyl-diphthamide synthesis from peptidyl-histidine", "peptidyl-diphthamide anabolism from peptidyl-histidine"], "types": ["T044"], "canonical_name": "peptidyl-diphthamide biosynthetic process from peptidyl-histidine", "definition": "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria. [GOC:pde, PMID:20559380, RESID:AA0040]"}
{"concept_id": "C1159173", "aliases": ["peptidyl-diphthamide breakdown", "peptidyl-diphthamide catabolism", "peptidyl-diphthamide degradation"], "types": ["T044"], "canonical_name": "peptidyl-diphthamide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue. [GOC:go_curators]"}
{"concept_id": "C1159174", "aliases": ["peptidyl-diphthine metabolism"], "types": ["T044"], "canonical_name": "peptidyl-diphthine metabolic process", "definition": "The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue. [GOC:go_curators]"}
{"concept_id": "C1159175", "aliases": ["peptidyl-diphthine formation from peptidyl-histidine", "peptidyl-diphthine anabolism from peptidyl-histidine", "peptidyl-diphthine synthesis from peptidyl-histidine"], "types": ["T044"], "canonical_name": "peptidyl-diphthine biosynthetic process from peptidyl-histidine", "definition": "The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine. [GOC:go_curators]"}
{"concept_id": "C1159176", "aliases": ["peptidyl-diphthine breakdown", "peptidyl-diphthine catabolism", "peptidyl-diphthine degradation"], "types": ["T044"], "canonical_name": "peptidyl-diphthine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue. [GOC:go_curators]"}
{"concept_id": "C1159178", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine methylation", "definition": "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). [RESID:AA0073, RESID:AA0317]"}
{"concept_id": "C1159179", "aliases": ["peptidyl-histidine pros-methylation"], "types": ["T044"], "canonical_name": "peptidyl-histidine methylation, to form pros-methylhistidine", "definition": "The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). [RESID:AA0073]"}
{"concept_id": "C1159180", "aliases": ["peptidyl-histidine tele-methylation"], "types": ["T044"], "canonical_name": "peptidyl-histidine methylation, to form tele-methylhistidine", "definition": "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine). [RESID:AA0317]"}
{"concept_id": "C1159181", "aliases": [], "types": ["T044"], "canonical_name": "protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine", "definition": "The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine. [RESID:AA0221]"}
{"concept_id": "C1159182", "aliases": [], "types": ["T044"], "canonical_name": "protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine", "definition": "The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine. [RESID:AA0144]"}
{"concept_id": "C1159183", "aliases": ["protein-haem linkage via 3'-L-histidine"], "types": ["T044"], "canonical_name": "protein-heme linkage via 3'-L-histidine", "definition": "The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine). [RESID:AA0276]"}
{"concept_id": "C1159184", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine", "definition": "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link. [RESID:AA0270]"}
{"concept_id": "C1159185", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine", "definition": "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link. [RESID:AA0250]"}
{"concept_id": "C1159186", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-isoleucine modification", "definition": "The modification of peptidyl-isoleucine. [GOC:go_curators]"}
{"concept_id": "C1159187", "aliases": ["peptidyl-leucine esterification"], "types": ["T044"], "canonical_name": "peptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine", "definition": "The modification of a C-terminal peptidyl-leucine to form peptidyl-L-leucine methyl ester. [RESID:AA0299]"}
{"concept_id": "C1159188", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-leucine modification", "definition": "The modification of peptidyl-leucine. [GOC:go_curators]"}
{"concept_id": "C1159189", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine modification", "definition": "The modification of peptidyl-lysine. [GOC:go_curators]"}
{"concept_id": "C1159190", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-allysine oxidation to 2-aminoadipic acid", "definition": "The oxidation of allysine to 2-aminoadipic acid. [RESID:AA0122]"}
{"concept_id": "C1159191", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine acetylation", "definition": "The acetylation of peptidyl-lysine. [GOC:mah]"}
{"concept_id": "C1159192", "aliases": [], "types": ["T044"], "canonical_name": "internal peptidyl-lysine acetylation", "definition": "The addition of an acetyl group to a non-terminal lysine residue in a protein. [GOC:mah]"}
{"concept_id": "C1159193", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine N6-acetylation", "definition": "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine. [RESID:AA0055]"}
{"concept_id": "C1159194", "aliases": ["peptidyl-lysine adenylation"], "types": ["T044"], "canonical_name": "peptidyl-lysine adenylylation", "definition": "The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine. [RESID:AA0227]"}
{"concept_id": "C1159196", "aliases": ["protein amino acid carboxyethylation"], "types": ["T044"], "canonical_name": "peptidyl-lysine carboxyethylation", "definition": "The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine. [RESID:AA0115]"}
{"concept_id": "C1159197", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine carboxylation", "definition": "The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine. [RESID:AA0114]"}
{"concept_id": "C1159198", "aliases": ["peptidyl-lysine esterification"], "types": ["T044"], "canonical_name": "peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine", "definition": "The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester. [RESID:AA0318]"}
{"concept_id": "C1159199", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine formylation", "definition": "The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine. [RESID:AA0211]"}
{"concept_id": "C1159200", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine guanylylation", "definition": "The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine. [RESID:AA0228]"}
{"concept_id": "C1159201", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine hydroxylation", "definition": "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine. [GOC:ai]"}
{"concept_id": "C1159202", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine", "definition": "The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine. [RESID:AA0235]"}
{"concept_id": "C1159203", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine", "definition": "The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine. [RESID:AA0028]"}
{"concept_id": "C1159205", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine methylation", "definition": "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. [GOC:ai]"}
{"concept_id": "C1159209", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine oxidation", "definition": "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens. [ISBN:0198547684, RESID:AA0121]"}
{"concept_id": "C1159210", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine palmitoylation", "definition": "The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine. [RESID:AA0077]"}
{"concept_id": "C1159211", "aliases": [], "types": ["T044"], "canonical_name": "poly-N-methyl-propylamination", "definition": "The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin. [RESID:AA0278]"}
{"concept_id": "C1159214", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone", "definition": "The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue. [RESID:AA0233]"}
{"concept_id": "C1159215", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-lysinoalanine", "definition": "The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link. [RESID:AA0123]"}
{"concept_id": "C1159216", "aliases": [], "types": ["T044"], "canonical_name": "protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine", "definition": "The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine. [RESID:AA0119]"}
{"concept_id": "C1159217", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-methionine modification", "definition": "The modification of peptidyl-methionine. [GOC:go_curators]"}
{"concept_id": "C1159218", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-methionine oxidation", "definition": "The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone. [RESID:AA0251]"}
{"concept_id": "C1159219", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-phenylalanine modification", "definition": "The modification of peptidyl-phenylalanine. [GOC:go_curators]"}
{"concept_id": "C1159220", "aliases": ["peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine", "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine", "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine"], "types": ["T044"], "canonical_name": "peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine", "definition": "The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid. [RESID:AA0128]"}
{"concept_id": "C1159225", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-proline modification", "definition": "The modification of peptidyl-proline. [GOC:go_curators]"}
{"concept_id": "C1159226", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-proline hydroxylation", "definition": "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. [GOC:mah]"}
{"concept_id": "C1159227", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-proline di-hydroxylation", "definition": "The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline. [RESID:AA0282]"}
{"concept_id": "C1159228", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-proline hydroxylation to 3-hydroxy-L-proline", "definition": "The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase. [RESID:AA0029]"}
{"concept_id": "C1159229", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine modification", "definition": "The modification of peptidyl-serine. [GOC:go_curators]"}
{"concept_id": "C1159230", "aliases": ["peptidyl-lactic acid formation from peptidyl-serine", "peptidyl-lactic acid synthesis from peptidyl-serine", "peptidyl-lactic acid anabolism from peptidyl-serine"], "types": ["T044"], "canonical_name": "peptidyl-lactic acid biosynthetic process from peptidyl-serine", "definition": "The modification of N-terminal peptidyl-serine to lactic acid. [RESID:AA0186]"}
{"concept_id": "C1159231", "aliases": ["peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine", "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine", "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine"], "types": ["T044"], "canonical_name": "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine", "definition": "The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine. [RESID:AA0264]"}
{"concept_id": "C1159232", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine ADP-ribosylation", "definition": "The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine. [RESID:AA0237]"}
{"concept_id": "C1159233", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine O-glucuronidation", "definition": "The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine. [RESID:AA0291]"}
{"concept_id": "C1159234", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine octanoylation", "definition": "The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin. [PMID:10604470, RESID:AA0290]"}
{"concept_id": "C1159235", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine phosphopantetheinylation", "definition": "The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine. [RESID:AA0150]"}
{"concept_id": "C1159236", "aliases": ["protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine"], "types": ["T044"], "canonical_name": "protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine", "definition": "Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. [PMID:7338506, RESID:AA0209]"}
{"concept_id": "C1159237", "aliases": ["protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine"], "types": ["T044"], "canonical_name": "protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine", "definition": "Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. [RESID:AA0210]"}
{"concept_id": "C1159238", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphoribosyl dephospho-coenzyme A linkage", "definition": "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position. [RESID:AA0167]"}
{"concept_id": "C1159239", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine", "definition": "The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine. [RESID:AA00167]"}
{"concept_id": "C1159240", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine modification", "definition": "The modification of peptidyl-threonine. [GOC:go_curators]"}
{"concept_id": "C1159241", "aliases": ["peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine", "peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine", "peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine"], "types": ["T044"], "canonical_name": "peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine", "definition": "The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine. [RESID:AA0182]"}
{"concept_id": "C1159242", "aliases": ["peptidyl-threonine adenylation"], "types": ["T044"], "canonical_name": "peptidyl-threonine adenylylation", "definition": "The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine. [RESID:AA0267]"}
{"concept_id": "C1159243", "aliases": ["protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine"], "types": ["T044"], "canonical_name": "protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine", "definition": "Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues. [RESID:AA0247]"}
{"concept_id": "C1159244", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tryptophan modification", "definition": "The chemical alteration of a tryptophan residue in a peptide. [GOC:isa_complete]"}
{"concept_id": "C1159246", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tryptophan hydroxylation", "definition": "The hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan. [RESID:AA0322]"}
{"concept_id": "C1159247", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tryptophan succinylation", "definition": "The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan. [RESID:AA0130]"}
{"concept_id": "C1159248", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone", "definition": "The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase. [RESID:AA0149]"}
{"concept_id": "C1159249", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tryptophan oxidation to tryptophyl quinone", "definition": "The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine. [PMID:2028257, RESID:AA0148]"}
{"concept_id": "C1159250", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tyrosine modification", "definition": "The modification of peptidyl-tyrosine. [GOC:go_curators]"}
{"concept_id": "C1159251", "aliases": ["DNA-protein covalent cross-linking via peptidyl-tyrosine"], "types": ["T045"], "canonical_name": "protein-DNA covalent cross-linking via peptidyl-tyrosine", "definition": "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue. [GOC:jsg]"}
{"concept_id": "C1159252", "aliases": ["DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine"], "types": ["T045"], "canonical_name": "protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine", "definition": "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine. [RESID:AA0323]"}
{"concept_id": "C1159253", "aliases": ["peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine", "peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine", "peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine"], "types": ["T044"], "canonical_name": "peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine", "definition": "The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases. [RESID:AA0147]"}
{"concept_id": "C1159254", "aliases": ["peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine", "peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine", "peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine"], "types": ["T044"], "canonical_name": "peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine", "definition": "The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine. [RESID:AA0263]"}
{"concept_id": "C1159255", "aliases": ["peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine", "peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine", "peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine"], "types": ["T044"], "canonical_name": "peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine", "definition": "The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA). [RESID:AA0146]"}
{"concept_id": "C1159256", "aliases": ["peptidyl-thyronine anabolism from peptidyl-tyrosine", "peptidyl-thyronine synthesis from peptidyl-tyrosine", "peptidyl-thyronine formation from peptidyl-tyrosine"], "types": ["T044"], "canonical_name": "peptidyl-thyronine biosynthetic process from peptidyl-tyrosine", "definition": "The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine. [GOC:jsg]"}
{"concept_id": "C1159260", "aliases": ["peptidyl-tyrosine adenylation"], "types": ["T044"], "canonical_name": "peptidyl-tyrosine adenylylation", "definition": "The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine. [RESID:AA0203]"}
{"concept_id": "C1159261", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tyrosine dehydrogenation", "definition": "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues. [RESID:AA0183]"}
{"concept_id": "C1159262", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tyrosine uridylylation", "definition": "The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase. [RESID:AA0256]"}
{"concept_id": "C1159263", "aliases": [], "types": ["T044"], "canonical_name": "protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine", "definition": "The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine. [RESID:AA0145]"}
{"concept_id": "C1159264", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-valine modification", "definition": "The modification of peptidyl-valine. [GOC:go_curators]"}
{"concept_id": "C1159266", "aliases": [], "types": ["T044"], "canonical_name": "internal protein amino acid acetylation", "definition": "The addition of an acetyl group to a non-terminal amino acid in a protein. [GOC:mah]"}
{"concept_id": "C1159267", "aliases": ["protein amino acid ADP-ribosylation"], "types": ["T044"], "canonical_name": "protein ADP-ribosylation", "definition": "The transfer, from NAD, of ADP-ribose to protein amino acids. [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295]"}
{"concept_id": "C1159268", "aliases": ["protein amino acid alkylation"], "types": ["T044"], "canonical_name": "protein alkylation", "definition": "The addition of an alkyl group to a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom. [GOC:ma]"}
{"concept_id": "C1159269", "aliases": ["protein amino acid methylation"], "types": ["T044"], "definition": "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. [GOC:ai]", "canonical_name": "protein methylation"}
{"concept_id": "C1159270", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamic acid methylation", "definition": "The addition of a methyl group to a glutamic acid residue in a protein. [GOC:mah]"}
{"concept_id": "C1159271", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamine methylation", "definition": "The addition of a methyl group to a glutamine residue in a protein. [GOC:mah]"}
{"concept_id": "C1159272", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamine 2-methylation", "definition": "The methylation of glutamine to form 2-methyl-L-glutamine. [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0273]"}
{"concept_id": "C1159273", "aliases": ["protein amino acid amidation"], "types": ["T044"], "canonical_name": "protein amidation", "definition": "Addition of an amide group from a glycine to a protein amino acid. [UniProtKB-KW:KW-0027]"}
{"concept_id": "C1159276", "aliases": ["protein amino acid carboxylation"], "types": ["T044"], "canonical_name": "protein carboxylation", "definition": "The addition of a carboxy group to a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159277", "aliases": ["protein amino acid deacetylation"], "types": ["T044"], "canonical_name": "protein deacetylation", "definition": "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]"}
{"concept_id": "C1159278", "aliases": ["protein amino acid dealkylation"], "types": ["T044"], "canonical_name": "protein dealkylation", "definition": "The removal of an alkyl group from a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom. [GOC:ai]"}
{"concept_id": "C1159279", "aliases": ["protein amino acid demethylation"], "types": ["T044"], "canonical_name": "protein demethylation", "definition": "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. [GOC:mah]"}
{"concept_id": "C1159280", "aliases": ["protein amino acid deamination"], "types": ["T044"], "canonical_name": "protein deamination", "definition": "The removal of an amino group from a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159281", "aliases": ["protein amino acid dehydration"], "types": ["T044"], "canonical_name": "protein dehydration", "definition": "The removal of a water group from a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159282", "aliases": ["protein amino acid desulphurisation", "protein amino acid desulfurisation", "protein amino acid desulfurization", "protein amino acid desulphurization"], "types": ["T044"], "canonical_name": "protein desulfurization", "definition": "The removal of a sulfur group from a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159284", "aliases": ["protein amino acid esterification"], "types": ["T044"], "canonical_name": "protein esterification", "definition": "The addition of an ester group to a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159285", "aliases": ["protein amino acid flavinylation"], "types": ["T044"], "canonical_name": "protein flavinylation", "definition": "The addition of a flavin group to a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159286", "aliases": ["protein amino acid formylation"], "types": ["T044"], "canonical_name": "protein formylation", "definition": "The addition of a formyl group to a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159287", "aliases": ["protein amino acid galactosylation"], "types": ["T044"], "canonical_name": "protein galactosylation", "definition": "The addition of a galactose molecule to a protein amino acid. [GOC:jl, GOC:pr]"}
{"concept_id": "C1159288", "aliases": ["protein amino acid glucuronidation"], "types": ["T044"], "canonical_name": "protein glucuronidation", "definition": "The modification of a protein by amino acid glucuronidation. [GOC:ai]"}
{"concept_id": "C1159289", "aliases": ["protein amino acid O-glucuronidation"], "types": ["T044"], "canonical_name": "protein O-glucuronidation", "definition": "The modification of a protein by glucuronidation on an amino acid oxygen atom. [GOC:mah]"}
{"concept_id": "C1159290", "aliases": ["protein amino acid uridylylation"], "types": ["T044"], "canonical_name": "protein uridylylation", "definition": "The addition of phospho-uridine to a protein amino acid. [GOC:jsg]"}
{"concept_id": "C1159294", "aliases": ["protein amino acid hydroxylation"], "types": ["T044"], "canonical_name": "protein hydroxylation", "definition": "The addition of a hydroxy group to a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159295", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tyrosine hydroxylation", "definition": "The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine. [GOC:ai]"}
{"concept_id": "C1159296", "aliases": ["protein amino acid nitrosylation"], "types": ["T044"], "canonical_name": "protein nitrosylation", "definition": "The covalent addition of a nitric oxide group to an amino acid within a protein. [GOC:ai, PMID:20972426]"}
{"concept_id": "C1159297", "aliases": ["protein amino acid nucleotidylation"], "types": ["T044"], "canonical_name": "protein nucleotidylation", "definition": "The addition of a nucleotide to a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159298", "aliases": ["protein amino acid adenylylation", "protein AMPylation", "protein adenylation"], "types": ["T044"], "canonical_name": "protein adenylylation", "definition": "The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid. [GOC:ai, GOC:jsg, GOC:sart, PMID:21607083]"}
{"concept_id": "C1159299", "aliases": ["protein amino acid guanylylation"], "types": ["T044"], "canonical_name": "protein guanylylation", "definition": "The addition of phospho-guanosine to a protein amino acid. [GOC:ai]"}
{"concept_id": "C1159300", "aliases": ["protein amino acid octanoylation"], "types": ["T044"], "canonical_name": "protein octanoylation", "definition": "The modification of a protein amino acid by formation of an ester or amide with octanoic acid. [GOC:jsg]"}
{"concept_id": "C1159301", "aliases": ["protein amino acid oxidation"], "types": ["T044"], "canonical_name": "protein oxidation", "definition": "The modification of a protein amino acid by oxidation. [GOC:ai]"}
{"concept_id": "C1159302", "aliases": ["protein amino acid phosphopantetheinylation"], "types": ["T044"], "canonical_name": "protein phosphopantetheinylation", "definition": "The modification of a protein amino acid by phosphopantetheinylation. [GOC:ai]"}
{"concept_id": "C1159303", "aliases": ["protein amino acid polyamination"], "types": ["T044"], "canonical_name": "protein polyamination", "definition": "The modification of a protein amino acid by polyamination. [GOC:ai]"}
{"concept_id": "C1159304", "aliases": ["protein amino acid succinylation"], "types": ["T044"], "canonical_name": "protein succinylation", "definition": "The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid residue. [GOC:bf]"}
{"concept_id": "C1159306", "aliases": [], "types": ["T044"], "canonical_name": "protein deneddylation", "definition": "The removal of a ubiquitin-like protein of the NEDD8 type from a protein. [GOC:krc]"}
{"concept_id": "C1159308", "aliases": ["RUB1-protein conjugation"], "types": ["T044"], "canonical_name": "protein neddylation", "definition": "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. [PMID:11698580]"}
{"concept_id": "C1159309", "aliases": [], "types": ["T044"], "canonical_name": "protein polyglycylation", "definition": "The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid. [RESID:AA0201]"}
{"concept_id": "C1159311", "aliases": ["pheromone processing"], "types": ["T044"], "canonical_name": "peptide pheromone maturation", "definition": "The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae. [GOC:elh]"}
{"concept_id": "C1159312", "aliases": [], "types": ["T044"], "canonical_name": "protein autoprocessing", "definition": "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. [GOC:ai, PMID:9335337]"}
{"concept_id": "C1159313", "aliases": ["leader peptide processing"], "types": ["T044"], "canonical_name": "signal peptide processing", "definition": "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1159314", "aliases": [], "types": ["T043"], "canonical_name": "viral protein processing", "definition": "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein. [GOC:bf, GOC:jl, ISBN:0781702534]"}
{"concept_id": "C1159318", "aliases": ["peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine"], "types": ["T044"], "canonical_name": "peptidyl-pyrromethane cofactor linkage", "definition": "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine. [RESID:AA0252]"}
{"concept_id": "C1159319", "aliases": [], "types": ["T044"], "canonical_name": "protein-coenzyme A linkage", "definition": "The formation of a linkage between a protein amino acid and coenzyme A. [GOC:mah]"}
{"concept_id": "C1159320", "aliases": [], "types": ["T044"], "canonical_name": "protein-FAD linkage", "definition": "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD). [GOC:ai]"}
{"concept_id": "C1159321", "aliases": [], "types": ["T044"], "canonical_name": "protein-FMN linkage", "definition": "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN). [GOC:mah]"}
{"concept_id": "C1159322", "aliases": ["peptidyl-lysine lipoylation", "protein-lipoic acid cofactor linkage"], "types": ["T044"], "canonical_name": "protein lipoylation", "definition": "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. [RESID:AA0118]"}
{"concept_id": "C1159323", "aliases": [], "types": ["T044"], "canonical_name": "protein-pyridoxal-5-phosphate linkage", "definition": "The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate. [GOC:mah]"}
{"concept_id": "C1159324", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking", "definition": "The formation of a covalent cross-link between or within protein chains. [GOC:jsg]"}
{"concept_id": "C1159325", "aliases": [], "types": ["T044"], "canonical_name": "isopeptide cross-linking", "definition": "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon. [GOC:jsg]"}
{"concept_id": "C1159326", "aliases": ["peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine", "peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine"], "types": ["T044"], "canonical_name": "peptide cross-linking via lanthionine or 3-methyl-lanthionine", "definition": "The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process. [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112]"}
{"concept_id": "C1159327", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-cystine", "definition": "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain. [RESID:AA0025]"}
{"concept_id": "C1159328", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-histidyl-L-tyrosine", "definition": "The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link. [GOC:ai]"}
{"concept_id": "C1159329", "aliases": [], "types": ["T044"], "canonical_name": "protein-tetrapyrrole linkage", "definition": "The covalent linking of a tetrapyrrole to a protein. [GOC:ai]"}
{"concept_id": "C1159330", "aliases": [], "types": ["T044"], "canonical_name": "protein-bilin linkage", "definition": "The covalent linkage of bilin and a protein. [GOC:ai]"}
{"concept_id": "C1159331", "aliases": [], "types": ["T044"], "canonical_name": "protein-phycobiliviolin linkage", "definition": "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin. [RESID:AA0258]"}
{"concept_id": "C1159332", "aliases": [], "types": ["T044"], "canonical_name": "protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine", "definition": "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine. [RESID:AA0258]"}
{"concept_id": "C1159333", "aliases": [], "types": ["T044"], "canonical_name": "protein-phycocyanobilin linkage", "definition": "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin. [RESID:AA0131]"}
{"concept_id": "C1159334", "aliases": [], "types": ["T044"], "canonical_name": "protein-phycoerythrobilin linkage", "definition": "The linkage of the chromophore phycoerythrobilin to phycoerythrins. [RESID:AA0132, RESID:AA0259]"}
{"concept_id": "C1159335", "aliases": [], "types": ["T044"], "canonical_name": "protein-phycourobilin linkage", "definition": "The linkage of the chromophore phycourobilin to phycoerythrins. [RESID:AA0260]"}
{"concept_id": "C1159336", "aliases": [], "types": ["T044"], "canonical_name": "protein-phytochromobilin linkage", "definition": "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin. [RESID:AA0133]"}
{"concept_id": "C1159337", "aliases": ["protein-haem linkage"], "types": ["T044"], "canonical_name": "protein-heme linkage", "definition": "The covalent linkage of heme and a protein. [GOC:ma]"}
{"concept_id": "C1159338", "aliases": [], "types": ["T044"], "canonical_name": "protein repair", "definition": "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. [GOC:mlg]"}
{"concept_id": "C1159339", "aliases": [], "types": ["T043"], "definition": "The controlled release of proteins from a cell. [GOC:ai]", "canonical_name": "protein secretion"}
{"concept_id": "C1159343", "aliases": ["constitutive exocytosis"], "types": ["T043"], "canonical_name": "constitutive secretory pathway", "definition": "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space. [GOC:mah, ISBN:0716731363]"}
{"concept_id": "C1159344", "aliases": ["rough endoplasmic reticulum to cis-Golgi transport", "rough ER to cis-Golgi transport", "anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi", "rough ER to cis-Golgi vesicle-mediated transport", "ER to Golgi vesicle-mediated transport", "anterograde (ER to Golgi) transport", "endoplasmic reticulum to Golgi vesicle-mediated transport", "endoplasmic reticulum to Golgi transport", "anterograde transport, endoplasmic reticulum to Golgi", "ER to Golgi transport", "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport", "anterograde vesicle-mediated transport, ER to Golgi"], "types": ["T043"], "definition": "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]", "canonical_name": "anterograde transport, ER to Golgi"}
{"concept_id": "C1159348", "aliases": ["calcium ion-dependent exocytosis"], "types": ["T043"], "canonical_name": "calcium-ion regulated exocytosis", "definition": "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. [GOC:go_curators]"}
{"concept_id": "C1159349", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium ion-dependent exocytosis", "definition": "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. [GOC:go_curators]"}
{"concept_id": "C1159350", "aliases": ["downregulation of calcium ion-dependent exocytosis", "down regulation of calcium ion-dependent exocytosis", "down-regulation of calcium ion-dependent exocytosis"], "types": ["T043"], "canonical_name": "negative regulation of calcium ion-dependent exocytosis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. [GOC:go_curators]"}
{"concept_id": "C1159351", "aliases": ["up regulation of calcium ion-dependent exocytosis", "upregulation of calcium ion-dependent exocytosis", "up-regulation of calcium ion-dependent exocytosis"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion-dependent exocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. [GOC:go_curators]"}
{"concept_id": "C1159356", "aliases": [], "types": ["T043"], "definition": "Any process that modulates the frequency, rate or extent of exocytosis. [GOC:go_curators]", "canonical_name": "regulation of exocytosis"}
{"concept_id": "C1159357", "aliases": ["down regulation of exocytosis", "down-regulation of exocytosis", "downregulation of exocytosis"], "types": ["T043"], "canonical_name": "negative regulation of exocytosis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. [GOC:go_curators]"}
{"concept_id": "C1159358", "aliases": ["upregulation of exocytosis", "up regulation of exocytosis", "up-regulation of exocytosis"], "types": ["T043"], "canonical_name": "positive regulation of exocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of exocytosis. [GOC:go_curators]"}
{"concept_id": "C1159359", "aliases": ["intra-Golgi transport"], "types": ["T043"], "canonical_name": "intra-Golgi vesicle-mediated transport", "definition": "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). [ISBN:0716731363]"}
{"concept_id": "C1159360", "aliases": ["cisternal maturation"], "types": ["T043"], "canonical_name": "cisternal progression", "definition": "The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna. [ISBN:0716731363]"}
{"concept_id": "C1159361", "aliases": ["retrograde (vesicle recycling within Golgi) transport"], "types": ["T043"], "canonical_name": "retrograde transport, vesicle recycling within Golgi", "definition": "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. [ISBN:0716731363]"}
{"concept_id": "C1159362", "aliases": ["post-Golgi transport"], "types": ["T043"], "canonical_name": "post-Golgi vesicle-mediated transport", "definition": "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. [GOC:ai, GOC:mah]"}
{"concept_id": "C1159363", "aliases": ["Golgi to plasma membrane vesicle-mediated transport"], "types": ["T043"], "canonical_name": "Golgi to plasma membrane transport", "definition": "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. [ISBN:0716731363]"}
{"concept_id": "C1159365", "aliases": ["Golgi to vacuole vesicle-mediated transport"], "types": ["T043"], "canonical_name": "Golgi to vacuole transport", "definition": "The directed movement of substances from the Golgi to the vacuole. [GOC:ai]"}
{"concept_id": "C1159366", "aliases": ["regulated secretory pathway"], "types": ["T040"], "canonical_name": "regulated exocytosis", "definition": "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. [GOC:mah, ISBN:0716731363]"}
{"concept_id": "C1159367", "aliases": ["retrograde (Golgi to ER) transport", "cis-Golgi to rough ER transport", "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport", "retrograde transport, Golgi to endoplasmic reticulum", "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "cis-Golgi to rough ER vesicle-mediated transport", "retrograde transport, Golgi to ER", "retrograde vesicle-mediated transport, Golgi to ER"], "types": ["T043"], "definition": "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. [ISBN:0716731363, PMID:16510524]", "canonical_name": "cis-Golgi to rough endoplasmic reticulum transport"}
{"concept_id": "C1159368", "aliases": ["type I protein secretion system", "protein secretion by the TOSS", "protein secretion by the type I protein secretion system"], "types": ["T043"], "canonical_name": "protein secretion by the type I secretion system", "definition": "The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. [GOC:pamgo_curators]"}
{"concept_id": "C1159369", "aliases": ["protein secretion by the type II protein secretion system", "type II protein secretion system", "protein secretion by the T2SS", "protein secretion by the T2S"], "types": ["T044"], "canonical_name": "protein secretion by the type II secretion system", "definition": "The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. [GOC:pamgo_curators]"}
{"concept_id": "C1159370", "aliases": ["protein secretion by the type III protein secretion system", "type III protein secretion system", "protein secretion by the TTSS", "protein secretion by the T3SS", "protein secretion by the T3S"], "types": ["T043"], "canonical_name": "protein secretion by the type III secretion system", "definition": "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. [GOC:pamgo_curators]"}
{"concept_id": "C1159371", "aliases": ["protein secretion by the T4SS", "protein secretion by the type IV protein secretion system", "type IV protein secretion system"], "types": ["T043"], "canonical_name": "protein secretion by the type IV secretion system", "definition": "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system. [GOC:pamgo_curators]"}
{"concept_id": "C1159372", "aliases": [], "types": ["T044"], "definition": "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. [GOC:ma]", "canonical_name": "protein targeting"}
{"concept_id": "C1159373", "aliases": ["protein membrane targeting", "protein-membrane targeting"], "types": ["T044"], "canonical_name": "protein targeting to membrane", "definition": "The process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:curators]"}
{"concept_id": "C1159374", "aliases": ["cotranslational protein-membrane targeting", "cotranslational protein membrane targeting", "cotranslational membrane targeting"], "types": ["T043"], "canonical_name": "cotranslational protein targeting to membrane", "definition": "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria. [ISBN:0716731363, PMID:10512867, PMID:16896215]"}
{"concept_id": "C1159375", "aliases": ["SRP-dependent cotranslational protein-membrane targeting", "SRP-dependent cotranslational protein targeting to membrane"], "types": ["T043"], "definition": "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. [ISBN:0716731363]", "canonical_name": "SRP-dependent cotranslational membrane targeting"}
{"concept_id": "C1159376", "aliases": ["SRP-dependent cotranslational protein-membrane targeting, docking", "protein docking during SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational membrane targeting, docking"], "types": ["T043"], "canonical_name": "SRP-dependent cotranslational protein targeting to membrane, docking", "definition": "The process in which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting. [ISBN:0815316194]"}
{"concept_id": "C1159377", "aliases": ["signal sequence processing during SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing", "SRP-dependent cotranslational membrane targeting, signal sequence processing"], "types": ["T043"], "canonical_name": "SRP-dependent cotranslational protein targeting to membrane, signal sequence processing", "definition": "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting. [ISBN:0815316194]"}
{"concept_id": "C1159378", "aliases": ["SRP-dependent cotranslational membrane targeting, translocation", "translocation during SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane, translocation"], "types": ["T043"], "definition": "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen. [ISBN:0716731363]", "canonical_name": "SRP-dependent cotranslational protein-membrane targeting, translocation"}
{"concept_id": "C1159379", "aliases": ["SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition", "SRP-dependent cotranslational membrane targeting, signal sequence recognition", "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane"], "types": ["T043"], "canonical_name": "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "definition": "The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting. [ISBN:0815316194]"}
{"concept_id": "C1159382", "aliases": ["posttranslational protein targeting to endoplasmic reticulum membrane", "posttranslational endoplasmic reticulum membrane targeting", "posttranslational endoplasmic reticulum protein-membrane targeting", "SRP-independent endoplasmic reticulum protein-membrane targeting", "posttranslational protein endoplasmic reticulum membrane targeting", "posttranslational protein targeting to ER membrane"], "types": ["T043"], "canonical_name": "post-translational protein targeting to endoplasmic reticulum membrane", "definition": "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. [ISBN:0716731363]"}
{"concept_id": "C1159383", "aliases": ["protein transport from nucleus to cytoplasm", "protein-nucleus export", "protein export from cell nucleus", "protein export out of nucleus"], "types": ["T043"], "canonical_name": "protein export from nucleus", "definition": "The directed movement of a protein from the nucleus into the cytoplasm. [GOC:jl]"}
{"concept_id": "C1159384", "aliases": ["MAPK transport from nucleus to cytoplasm", "MAPK export out of nucleus", "MAPK-nucleus export", "cytoplasmic translocation of mitogen-activated protein kinase", "cytoplasmic translocation of MAP kinase", "MAPK export from cell nucleus"], "types": ["T043"], "canonical_name": "MAPK export from nucleus", "definition": "The directed movement of a MAP kinase from the nucleus to the cytoplasm. [GOC:ebc]"}
{"concept_id": "C1159385", "aliases": ["MAPK phosphatase-nucleus export", "MAPK phosphatase transport from nucleus to cytoplasm", "MAPK phosphatase export from cell nucleus", "MAPK phosphatase export out of nucleus"], "types": ["T040"], "canonical_name": "MAPK phosphatase export from nucleus", "definition": "The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm. [GOC:ebc]"}
{"concept_id": "C1159386", "aliases": ["MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive", "leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm", "leptomycin B-sensitive MAPK phosphatase-nucleus export", "MAPK phosphatase-nucleus export, leptomycin B sensitive", "MAPK phosphatase export out of nucleus, leptomycin B sensitive", "leptomycin B-sensitive MAPK phosphatase export out of nucleus", "MAPK phosphatase export from cell nucleus, leptomycin B sensitive"], "types": ["T040"], "canonical_name": "MAPK phosphatase export from nucleus, leptomycin B sensitive", "definition": "Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm. [GOC:ebc]"}
{"concept_id": "C1159387", "aliases": ["protein transport from cytoplasm to nucleus", "protein import into cell nucleus", "establishment of protein localization to nucleus", "protein nucleus import"], "types": ["T043"], "canonical_name": "protein import into nucleus", "definition": "The directed movement of a protein from the cytoplasm to the nucleus. [GOC:jl]"}
{"concept_id": "C1159393", "aliases": ["NLS-bearing substrate transport from cytoplasm to nucleus", "NLS-bearing substrate import into nucleus", "NLS-bearing substrate-nucleus import", "NLS-bearing substrate import into cell nucleus"], "types": ["T043"], "canonical_name": "NLS-bearing protein import into nucleus", "definition": "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope. [GOC:ai]"}
{"concept_id": "C1159397", "aliases": ["regulation of protein-nucleus import", "regulation of protein transport from cytoplasm to nucleus", "regulation of protein import into cell nucleus"], "types": ["T043"], "canonical_name": "regulation of protein import into nucleus", "definition": "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus. [GOC:jl]"}
{"concept_id": "C1159398", "aliases": ["down-regulation of protein import into nucleus", "negative regulation of protein import into cell nucleus", "downregulation of protein import into nucleus", "down regulation of protein import into nucleus", "negative regulation of protein-nucleus import", "negative regulation of protein transport from cytoplasm to nucleus"], "types": ["T043"], "canonical_name": "negative regulation of protein import into nucleus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. [GOC:jl]"}
{"concept_id": "C1159399", "aliases": ["up-regulation of protein import into nucleus", "up regulation of protein import into nucleus", "positive regulation of protein transport from cytoplasm to nucleus", "upregulation of protein import into nucleus", "positive regulation of protein import into cell nucleus", "positive regulation of protein-nucleus import"], "types": ["T043"], "canonical_name": "positive regulation of protein import into nucleus", "definition": "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. [GOC:jl]"}
{"concept_id": "C1159400", "aliases": ["ribosomal protein import into cell nucleus", "ribosomal protein-nucleus import", "ribosomal protein transport from cytoplasm to nucleus"], "types": ["T043"], "canonical_name": "ribosomal protein import into nucleus", "definition": "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus. [GOC:ai, PMID:11809816]"}
{"concept_id": "C1159402", "aliases": ["regulation of metabolism"], "types": ["T040"], "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]", "canonical_name": "regulation of metabolic process"}
{"concept_id": "C1159403", "aliases": ["downregulation of metabolic process", "down regulation of metabolic process", "negative regulation of metabolism", "down-regulation of metabolic process", "negative regulation of organismal metabolism"], "types": ["T044"], "canonical_name": "negative regulation of metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]"}
{"concept_id": "C1159404", "aliases": ["up-regulation of metabolic process", "positive regulation of metabolism", "up regulation of metabolic process", "upregulation of metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]"}
{"concept_id": "C1159405", "aliases": ["metabolic burst at fertilization", "oxidative burst at fertilization"], "types": ["T043"], "canonical_name": "respiratory burst at fertilization", "definition": "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes. [ISBN:0198506732, PMID:2537493, PMID:9013127]"}
{"concept_id": "C1159406", "aliases": ["regulation of sulphur utilization"], "types": ["T043"], "canonical_name": "regulation of sulfur utilization", "definition": "Any process that modulates the frequency, rate or extent of sulfur utilization. [GOC:go_curators]"}
{"concept_id": "C1159407", "aliases": ["down regulation of sulfur utilization", "downregulation of sulfur utilization", "negative regulation of sulphur utilization", "down-regulation of sulfur utilization"], "types": ["T043"], "canonical_name": "negative regulation of sulfur utilization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization. [GOC:go_curators]"}
{"concept_id": "C1159408", "aliases": ["up-regulation of sulfur utilization", "positive regulation of sulphur utilization", "upregulation of sulfur utilization", "up regulation of sulfur utilization"], "types": ["T043"], "canonical_name": "positive regulation of sulfur utilization", "definition": "Any process that activates or increases the frequency, rate or extent of sulfur utilization. [GOC:go_curators]"}
{"concept_id": "C1159409", "aliases": ["sulfur compound metabolic process", "sulphur metabolic process", "sulfur metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. [GOC:ai]", "canonical_name": "sulphur metabolism"}
{"concept_id": "C1159410", "aliases": ["alkanesulfonate metabolism", "alkanesulphonate metabolism", "alkanesulphonate metabolic process"], "types": ["T044"], "canonical_name": "alkanesulfonate metabolic process", "definition": "The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. [GOC:ai]"}
{"concept_id": "C1159411", "aliases": ["DMSO metabolic process", "dimethyl sulphoxide metabolic process", "dimethyl sulfoxide metabolism", "dimethyl sulphoxide metabolism", "DMSO metabolism"], "types": ["T044"], "canonical_name": "dimethyl sulfoxide metabolic process", "definition": "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing. [GOC:curators]"}
{"concept_id": "C1159412", "aliases": ["organosulphide cycle"], "types": ["T044"], "canonical_name": "organosulfide cycle", "definition": "A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle. [UM-BBD_pathwayID:sulf]"}
{"concept_id": "C1159413", "aliases": [], "types": ["T044"], "canonical_name": "polythionate oxidation", "definition": "The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor. [MetaCyc:THIOSULFOX-PWY]"}
{"concept_id": "C1159414", "aliases": ["sulphur utilization"], "types": ["T043"], "canonical_name": "sulfur utilization", "definition": "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism. [GOC:mah, GOC:mlg]"}
{"concept_id": "C1159415", "aliases": ["bisulphite reduction"], "types": ["T044"], "canonical_name": "bisulfite reduction", "definition": "The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite. [MetaCyc:P224-PWY]"}
{"concept_id": "C1159416", "aliases": ["disproportionation of elemental sulphur"], "types": ["T044"], "canonical_name": "disproportionation of elemental sulfur", "definition": "The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2. [MetaCyc:P203-PWY]"}
{"concept_id": "C1159417", "aliases": ["sulphate assimilation"], "types": ["T043"], "canonical_name": "sulfate assimilation", "definition": "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. [GOC:jl]"}
{"concept_id": "C1159419", "aliases": ["sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin)"], "types": ["T044"], "canonical_name": "sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)", "definition": "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8). [GOC:jl]"}
{"concept_id": "C1159420", "aliases": ["sulphate reduction"], "types": ["T044"], "canonical_name": "sulfate reduction", "definition": "The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. [MetaCyc:DISSULFRED-PWY, MetaCyc:P224-PWY, MetaCyc:SO4ASSIM-PWY, MetaCyc:SULFMETII-PWY]"}
{"concept_id": "C1159421", "aliases": ["dissimilatory sulphate reduction"], "types": ["T044"], "canonical_name": "dissimilatory sulfate reduction", "definition": "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide. [GOC:jl, MetaCyc:DISSULFRED-PWY]"}
{"concept_id": "C1159422", "aliases": ["sulphate reduction, APS pathway"], "types": ["T044"], "canonical_name": "sulfate reduction, APS pathway"}
{"concept_id": "C1159423", "aliases": ["sulphide oxidation"], "types": ["T044"], "canonical_name": "sulfide oxidation", "definition": "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate. [MetaCyc:P222-PWY, MetaCyc:P223-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285]"}
{"concept_id": "C1159424", "aliases": ["sulphide oxidation, using siroheme sulphite reductase", "sulfide oxidation, using sirohaem sulfite reductase"], "types": ["T044"], "canonical_name": "sulfide oxidation, using siroheme sulfite reductase", "definition": "A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase. [MetaCyc:P223-PWY]"}
{"concept_id": "C1159425", "aliases": ["sulphur oxidation"], "types": ["T044"], "canonical_name": "sulfur oxidation", "definition": "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur. [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY]"}
{"concept_id": "C1159426", "aliases": ["sulphur oxidation, ferric ion-dependent"], "types": ["T044"], "canonical_name": "sulfur oxidation, ferric ion-dependent", "definition": "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+). [MetaCyc:FESULFOX-PWY]"}
{"concept_id": "C1159427", "aliases": ["sulfur oxidation, using sirohaem sulfite reductase", "sulphur oxidation, using siroheme sulphite reductase"], "types": ["T044"], "canonical_name": "sulfur oxidation, using siroheme sulfite reductase"}
{"concept_id": "C1159428", "aliases": ["terpene metabolism"], "types": ["T044"], "canonical_name": "terpene metabolic process", "definition": "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups. [GOC:curators]"}
{"concept_id": "C1159429", "aliases": ["alpha-pinene metabolism"], "types": ["T044"], "canonical_name": "alpha-pinene metabolic process", "definition": "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor. [UM-BBD_pathwayID:apn]"}
{"concept_id": "C1159430", "aliases": ["limonene metabolism"], "types": ["T044"], "canonical_name": "limonene metabolic process", "definition": "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. [UM-BBD_pathwayID:lim]"}
{"concept_id": "C1159431", "aliases": ["fat-soluble vitamin metabolism"], "types": ["T044"], "canonical_name": "fat-soluble vitamin metabolic process", "definition": "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1159432", "aliases": ["vitamin A metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]", "canonical_name": "vitamin A metabolic process"}
{"concept_id": "C1159433", "aliases": ["calciferol metabolic process", "vitamin D metabolic process", "calciferol metabolism", "ergocalciferol metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]", "canonical_name": "vitamin D metabolism"}
{"concept_id": "C1159434", "aliases": ["tocopherol metabolic process", "tocopherol metabolism", "vitamin E metabolism"], "types": ["T044"], "canonical_name": "vitamin E metabolic process", "definition": "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1159435", "aliases": ["regulation of vitamin metabolism"], "types": ["T044"], "canonical_name": "regulation of vitamin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:mah]"}
{"concept_id": "C1159436", "aliases": ["downregulation of vitamin metabolic process", "down-regulation of vitamin metabolic process", "negative regulation of vitamin metabolism", "down regulation of vitamin metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of vitamin metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]"}
{"concept_id": "C1159437", "aliases": ["up regulation of vitamin metabolic process", "upregulation of vitamin metabolic process", "up-regulation of vitamin metabolic process", "positive regulation of vitamin metabolism"], "types": ["T043"], "canonical_name": "positive regulation of vitamin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]"}
{"concept_id": "C1159438", "aliases": ["water-soluble vitamin metabolism"], "types": ["T044"], "canonical_name": "water-soluble vitamin metabolic process", "definition": "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. [GOC:jl]"}
{"concept_id": "C1159439", "aliases": ["vitamin B1 metabolism", "thiamine metabolic process", "thiamin metabolism", "vitamin B1 metabolic process", "thiamin metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:jl, ISBN:0198506732]", "canonical_name": "thiamine metabolism"}
{"concept_id": "C1159440", "aliases": ["vitamin G metabolic process", "vitamin B2 metabolic process", "riboflavin metabolism", "vitamin B2 metabolism", "riboflavin metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]", "canonical_name": "vitamin G metabolism"}
{"concept_id": "C1159441", "aliases": ["response to hypoxic stress", "response to lowered oxygen tension"], "types": ["T043"], "canonical_name": "response to hypoxia", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]"}
{"concept_id": "C1159442", "aliases": ["spore differentiation", "cellular spore formation by sporulation", "spore biosynthesis", "spore formation"], "types": ["T043"], "canonical_name": "sporulation resulting in formation of a cellular spore", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. [GOC:mah, GOC:pamgo_curators, ISBN:0072992913]"}
{"concept_id": "C1159446", "aliases": ["spore coat biosynthetic process", "spore wall assembly", "spore wall formation", "spore coat biosynthesis"], "types": ["T043"], "canonical_name": "spore wall assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore. [GOC:mah, GOC:pg]"}
{"concept_id": "C1159451", "aliases": ["ascospore biosynthesis"], "types": ["T043"], "canonical_name": "ascospore formation", "definition": "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota). [GOC:di, GOC:mah, GOC:mcc, PMID:16339736]"}
{"concept_id": "C1159455", "aliases": [], "types": ["T043"], "canonical_name": "syncytium formation", "definition": "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. [ISBN:0198506732]"}
{"concept_id": "C1159456", "aliases": [], "types": ["T043"], "canonical_name": "syncytium formation by mitosis without cell division"}
{"concept_id": "C1159457", "aliases": [], "types": ["T043"], "canonical_name": "2-keto-3-deoxygluconate transport"}
{"concept_id": "C1159458", "aliases": [], "types": ["T043"], "canonical_name": "aerobactin transport", "definition": "The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. [GOC:ai, PMID:23192658]"}
{"concept_id": "C1159459", "aliases": [], "types": ["T043"], "canonical_name": "amine transport", "definition": "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1159460", "aliases": ["betaine transport"], "types": ["T043"], "canonical_name": "amino-acid betaine transport", "definition": "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159461", "aliases": [], "types": ["T043"], "canonical_name": "cadaverine transport", "definition": "The directed movement of cadaverine, 1,5-pentanediamine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159462", "aliases": [], "types": ["T043"], "canonical_name": "chromaffin granule amine transport", "definition": "The directed movement of amines into, out of or within chromaffin granules. [GOC:mah]"}
{"concept_id": "C1159463", "aliases": [], "types": ["T043"], "canonical_name": "methylammonium transport", "definition": "The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159464", "aliases": [], "types": ["T043"], "canonical_name": "monoamine transport", "definition": "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1159465", "aliases": [], "types": ["T043"], "canonical_name": "polyamine transport", "definition": "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc, ISBN:0198506732]"}
{"concept_id": "C1159466", "aliases": [], "types": ["T043"], "canonical_name": "putrescine transport", "definition": "The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. [GOC:krc, ISBN:0198506732]"}
{"concept_id": "C1159467", "aliases": [], "types": ["T043"], "canonical_name": "spermidine transport", "definition": "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc, ISBN:0198506732]"}
{"concept_id": "C1159468", "aliases": [], "types": ["T043"], "canonical_name": "spermine transport", "definition": "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc, ISBN:0198506732]"}
{"concept_id": "C1159470", "aliases": [], "types": ["T043"], "canonical_name": "aminergic neurotransmitter loading into synaptic vesicle", "definition": "The active transport of aminergic neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action proton pumps. [GOC:ai]"}
{"concept_id": "C1159471", "aliases": [], "types": ["T043"], "canonical_name": "urea transport", "definition": "The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1159472", "aliases": [], "types": ["T043"], "canonical_name": "acidic amino acid transport", "definition": "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159473", "aliases": [], "types": ["T043"], "canonical_name": "L-aspartate transport"}
{"concept_id": "C1159474", "aliases": ["mitochondrial aspartate/glutamate transport"], "types": ["T043"], "canonical_name": "mitochondrial aspartate/glutamate transport", "definition": "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion. [GOC:ai]"}
{"concept_id": "C1159475", "aliases": [], "types": ["T043"], "canonical_name": "L-glutamate transport"}
{"concept_id": "C1159476", "aliases": [], "types": ["T043"], "canonical_name": "p-aminobenzoyl-glutamate transport", "definition": "The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159477", "aliases": [], "types": ["T043"], "canonical_name": "aromatic amino acid transport", "definition": "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159478", "aliases": [], "types": ["T043"], "canonical_name": "L-phenylalanine transport"}
{"concept_id": "C1159479", "aliases": [], "types": ["T043"], "canonical_name": "L-tryptophan transport"}
{"concept_id": "C1159480", "aliases": [], "types": ["T043"], "canonical_name": "L-tyrosine transport"}
{"concept_id": "C1159481", "aliases": [], "types": ["T043"], "canonical_name": "basic amino acid transport", "definition": "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159483", "aliases": [], "types": ["T043"], "canonical_name": "L-asparagine transport"}
{"concept_id": "C1159484", "aliases": [], "types": ["T043"], "canonical_name": "L-glutamine transport"}
{"concept_id": "C1159485", "aliases": ["L-histidine transport"], "types": ["T043"], "canonical_name": "L-histidine transport", "definition": "The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:kmv, GOC:TermGenie, PMID:22822152]"}
{"concept_id": "C1159486", "aliases": ["L-lysine transport"], "types": ["T043"], "canonical_name": "L-lysine transport", "definition": "The directed movement of a L-lysine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:kmv, GOC:TermGenie, PMID:22822152]"}
{"concept_id": "C1159487", "aliases": ["branched-chain amino-acid anions transport", "branched-chain aliphatic amino acid transport", "branched-chain amino-acid anion transport"], "types": ["T043"], "canonical_name": "branched-chain amino acid transport", "definition": "The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. [GOC:ai, GOC:bf]"}
{"concept_id": "C1159488", "aliases": [], "types": ["T043"], "canonical_name": "L-isoleucine transport"}
{"concept_id": "C1159489", "aliases": [], "types": ["T043"], "canonical_name": "L-valine transport"}
{"concept_id": "C1159490", "aliases": [], "types": ["T043"], "canonical_name": "extracellular amino acid transport", "definition": "The directed extracellular movement of amino acids. [GOC:ai]"}
{"concept_id": "C1159491", "aliases": [], "types": ["T043"], "canonical_name": "L-amino acid transport", "definition": "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1159492", "aliases": [], "types": ["T043"], "canonical_name": "L-alanine transport", "definition": "The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1159493", "aliases": [], "types": ["T043"], "canonical_name": "L-cystine transport", "definition": "The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1159494", "aliases": [], "types": ["T043"], "canonical_name": "diaminopimelate transport", "definition": "The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1159496", "aliases": [], "types": ["T043"], "canonical_name": "glycine transport", "definition": "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159497", "aliases": [], "types": ["T043"], "canonical_name": "L-leucine transport"}
{"concept_id": "C1159498", "aliases": [], "types": ["T043"], "canonical_name": "L-methionine transport"}
{"concept_id": "C1159499", "aliases": [], "types": ["T043"], "canonical_name": "L-ornithine transport"}
{"concept_id": "C1159501", "aliases": [], "types": ["T043"], "canonical_name": "L-proline transport"}
{"concept_id": "C1159502", "aliases": [], "types": ["T043"], "canonical_name": "L-serine transport", "definition": "The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1159503", "aliases": [], "types": ["T043"], "canonical_name": "L-threonine transport"}
{"concept_id": "C1159504", "aliases": [], "types": ["T043"], "canonical_name": "neutral amino acid transport", "definition": "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159505", "aliases": ["sulphur amino acid transport"], "types": ["T043"], "canonical_name": "sulfur amino acid transport", "definition": "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159506", "aliases": ["S-adenosyl methionine transport", "SAM transport", "S-adenosylmethionine transport"], "types": ["T043"], "canonical_name": "S-adenosyl-L-methionine transport", "definition": "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159507", "aliases": [], "types": ["T043"], "canonical_name": "S-methylmethionine transport", "definition": "The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159508", "aliases": [], "types": ["T043"], "canonical_name": "boron transport"}
{"concept_id": "C1159509", "aliases": [], "types": ["T043"], "canonical_name": "disaccharide transport", "definition": "The directed movement of disaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units. [GOC:ai]"}
{"concept_id": "C1159510", "aliases": [], "types": ["T043"], "canonical_name": "cellobiose transport", "definition": "The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. [GOC:ai]"}
{"concept_id": "C1159511", "aliases": [], "types": ["T043"], "canonical_name": "lactose transport", "definition": "The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. [GOC:ai]"}
{"concept_id": "C1159512", "aliases": [], "types": ["T043"], "canonical_name": "maltose transport", "definition": "The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch. [GOC:ai]"}
{"concept_id": "C1159513", "aliases": [], "types": ["T043"], "canonical_name": "melibiose transport", "definition": "The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. [GOC:ai]"}
{"concept_id": "C1159514", "aliases": [], "types": ["T043"], "canonical_name": "sucrose transport", "definition": "The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside. [GOC:ai]"}
{"concept_id": "C1159515", "aliases": [], "types": ["T043"], "canonical_name": "trehalose transport", "definition": "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. [GOC:ai]"}
{"concept_id": "C1159517", "aliases": [], "types": ["T043"], "canonical_name": "alpha-glucoside transport", "definition": "The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. [GOC:jl, ISBN:0198506732, PMID:9919658]"}
{"concept_id": "C1159518", "aliases": [], "types": ["T043"], "canonical_name": "hexuronide transport"}
{"concept_id": "C1159519", "aliases": ["glucuronide transport"], "types": ["T043"], "canonical_name": "glucuronoside transport", "definition": "The directed movement of glucuronosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate. [GOC:ai]"}
{"concept_id": "C1159520", "aliases": [], "types": ["T043"], "canonical_name": "monosaccharide transport"}
{"concept_id": "C1159521", "aliases": [], "types": ["T043"], "canonical_name": "hexose transport"}
{"concept_id": "C1159522", "aliases": [], "types": ["T043"], "canonical_name": "allose transport"}
{"concept_id": "C1159523", "aliases": [], "types": ["T043"], "canonical_name": "fructose transport"}
{"concept_id": "C1159524", "aliases": [], "types": ["T043"], "canonical_name": "fucose transport"}
{"concept_id": "C1159525", "aliases": [], "types": ["T043"], "canonical_name": "galactose transport"}
{"concept_id": "C1159526", "aliases": [], "types": ["T043"], "canonical_name": "beta-glucoside transport", "definition": "The directed movement of beta-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration. [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732]"}
{"concept_id": "C1159527", "aliases": ["glucose uptake"], "types": ["T043"], "definition": "The directed movement of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai]", "canonical_name": "glucose import"}
{"concept_id": "C1159528", "aliases": ["regulation of glucose uptake"], "types": ["T043"], "canonical_name": "regulation of glucose import", "definition": "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai]"}
{"concept_id": "C1159529", "aliases": ["negative regulation of glucose uptake", "downregulation of glucose import", "down-regulation of glucose import", "down regulation of glucose import"], "types": ["T043"], "canonical_name": "negative regulation of glucose import", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai]"}
{"concept_id": "C1159530", "aliases": ["upregulation of glucose import", "positive regulation of glucose uptake", "up-regulation of glucose import", "positive regulation of glucose import"], "types": ["T043"], "definition": "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai, GOC:dph, GOC:tb]", "canonical_name": "up regulation of glucose import"}
{"concept_id": "C1159531", "aliases": [], "types": ["T043"], "canonical_name": "glucose-6-phosphate transport", "definition": "The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. [GOC:ai]"}
{"concept_id": "C1159534", "aliases": [], "types": ["T043"], "canonical_name": "mannose transport"}
{"concept_id": "C1159535", "aliases": [], "types": ["T043"], "canonical_name": "methylgalactoside transport", "definition": "The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. [GOC:curators]"}
{"concept_id": "C1159536", "aliases": [], "types": ["T043"], "canonical_name": "N-acetylgalactosamine transport", "definition": "The directed movement of N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine. [GOC:ai]"}
{"concept_id": "C1159537", "aliases": [], "types": ["T043"], "canonical_name": "N-acetylglucosamine transport", "definition": "The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1159538", "aliases": [], "types": ["T043"], "canonical_name": "rhamnose transport"}
{"concept_id": "C1159539", "aliases": [], "types": ["T043"], "canonical_name": "pentose transport"}
{"concept_id": "C1159540", "aliases": [], "types": ["T043"], "canonical_name": "arabinose transport"}
{"concept_id": "C1159543", "aliases": [], "types": ["T043"], "canonical_name": "nucleotide-sugar transport"}
{"concept_id": "C1159545", "aliases": [], "types": ["T043"], "canonical_name": "CMP-sialic acid transport"}
{"concept_id": "C1159546", "aliases": [], "types": ["T043"], "canonical_name": "GDP-fucose transport"}
{"concept_id": "C1159549", "aliases": [], "types": ["T043"], "canonical_name": "UDP-glucose transmembrane transport", "definition": "The process in which UDP-glucose is transported across a membrane. [GOC:ai]"}
{"concept_id": "C1159550", "aliases": [], "types": ["T043"], "canonical_name": "UDP-glucuronic acid transport"}
{"concept_id": "C1159551", "aliases": [], "types": ["T043"], "canonical_name": "UDP-N-acetylgalactosamine transport"}
{"concept_id": "C1159553", "aliases": [], "types": ["T043"], "canonical_name": "UDP-xylose transport"}
{"concept_id": "C1159554", "aliases": [], "types": ["T043"], "canonical_name": "oligosaccharide transport", "definition": "The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [GOC:ai]"}
{"concept_id": "C1159555", "aliases": [], "types": ["T043"], "canonical_name": "raffinose transport", "definition": "The directed movement of raffinose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol. [ISBN:0198506732]"}
{"concept_id": "C1159556", "aliases": [], "types": ["T043"], "canonical_name": "phloem sucrose loading", "definition": "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink. [GOC:sm]"}
{"concept_id": "C1159557", "aliases": [], "types": ["T044"], "canonical_name": "phosphoenolpyruvate-dependent sugar phosphotransferase system", "definition": "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. [PMID:31209249, PMID:33820910]"}
{"concept_id": "C1159558", "aliases": [], "types": ["T043"], "canonical_name": "polysaccharide transport", "definition": "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:ai]"}
{"concept_id": "C1159559", "aliases": [], "types": ["T043"], "canonical_name": "beta-glucan transport", "definition": "The directed movement of beta-glucans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds. [GOC:ai]"}
{"concept_id": "C1159560", "aliases": ["capsule polysaccharide transport", "capsular-polysaccharide transport"], "types": ["T043"], "canonical_name": "capsular polysaccharide transport", "definition": "The directed movement of capsular polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi. [GOC:ai]"}
{"concept_id": "C1159561", "aliases": [], "types": ["T043"], "canonical_name": "teichoic acid transport", "definition": "The directed movement of teichoic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. [GOC:ai]"}
{"concept_id": "C1159563", "aliases": [], "types": ["T043"], "definition": "The directed movement of substances or organelles within the cytosol. [GOC:ai]", "canonical_name": "cytosolic transport"}
{"concept_id": "C1159564", "aliases": [], "types": ["T042"], "canonical_name": "cytoplasmic transport, nurse cell to oocyte", "definition": "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte. [ISBN:0879694238]"}
{"concept_id": "C1159565", "aliases": [], "types": ["T043"], "canonical_name": "cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte", "definition": "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte. [GOC:ai]"}
{"concept_id": "C1159567", "aliases": ["nuclear egress", "nuclear egress of viral procapsid", "capsid egress", "egress of viral procapsid from host cell nucleus"], "types": ["T043"], "canonical_name": "exit of virus from host cell nucleus by nuclear egress", "definition": "The directed movement of an assembled viral particle out of the host cell nucleus by budding and fusion through the nuclear membranes. In this process, enveloped viral particles are formed by budding through the inner nuclear membrane. These perinuclear enveloped particles then fuse with the outer nuclear membrane to deliver a naked capsid into the host cytoplasm. [PMID:21494278, PMID:22858153, PMID:9601512, PMID:9765421, VZ:1952]"}
{"concept_id": "C1159568", "aliases": [], "types": ["T043"], "canonical_name": "extracellular transport", "definition": "The transport of substances that occurs outside cells. [GOC:go_curators]"}
{"concept_id": "C1159569", "aliases": [], "types": ["T043"], "canonical_name": "fluid transport", "definition": "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159570", "aliases": [], "types": ["T043"], "canonical_name": "epithelial fluid transport", "definition": "The directed movement of fluid across epithelia. [GOC:jl, PMID:11390830]"}
{"concept_id": "C1159571", "aliases": [], "types": ["T043"], "definition": "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "canonical_name": "water transport"}
{"concept_id": "C1159572", "aliases": [], "types": ["T043"], "definition": "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "canonical_name": "gas transport"}
{"concept_id": "C1159573", "aliases": [], "types": ["T043"], "canonical_name": "hormone transport", "definition": "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:tb]"}
{"concept_id": "C1159574", "aliases": [], "types": ["T043"], "canonical_name": "auxin polar transport", "definition": "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally. [GOC:sm]"}
{"concept_id": "C1159576", "aliases": [], "types": ["T043"], "canonical_name": "proton transport"}
{"concept_id": "C1159578", "aliases": [], "types": ["T043"], "canonical_name": "ATP hydrolysis coupled proton transport"}
{"concept_id": "C1159579", "aliases": [], "types": ["T044"], "canonical_name": "electron transport coupled proton transport", "definition": "The transport of protons against an electrochemical gradient, using energy from electron transport. [GOC:mah]"}
{"concept_id": "C1159580", "aliases": [], "types": ["T044"], "canonical_name": "light-driven proton transport", "definition": "The transport of protons against an electrochemical gradient, using energy from light. [GOC:mah]"}
{"concept_id": "C1159581", "aliases": [], "types": ["T044"], "canonical_name": "energy coupled proton transport, down electrochemical gradient", "definition": "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP. [GOC:mah]"}
{"concept_id": "C1159582", "aliases": ["ATP synthesis coupled proton transport"], "types": ["T044"], "canonical_name": "proton motive force-driven ATP synthesis", "definition": "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. [ISBN:0716731363]"}
{"concept_id": "C1159583", "aliases": [], "types": ["T044"], "canonical_name": "GTP synthesis coupled proton transport", "definition": "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis. [ISBN:0716731363]"}
{"concept_id": "C1159584", "aliases": [], "types": ["T043"], "canonical_name": "passive proton transport, down the electrochemical gradient", "definition": "OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low. [ISBN:0716731363]"}
{"concept_id": "C1159585", "aliases": [], "types": ["T043"], "canonical_name": "anion transport", "definition": "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159586", "aliases": [], "types": ["T043"], "canonical_name": "inorganic anion transport", "definition": "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. [GOC:krc]"}
{"concept_id": "C1159587", "aliases": [], "types": ["T043"], "canonical_name": "antimonite transport", "definition": "The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159588", "aliases": [], "types": ["T043"], "canonical_name": "arsenite transport", "definition": "The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159589", "aliases": [], "types": ["T043"], "canonical_name": "bicarbonate transport", "definition": "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159590", "aliases": [], "types": ["T043"], "canonical_name": "chlorate transport", "definition": "The directed movement of chlorate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159591", "aliases": [], "types": ["T043"], "definition": "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "canonical_name": "chloride transport"}
{"concept_id": "C1159592", "aliases": [], "types": ["T043"], "canonical_name": "transepithelial chloride transport", "definition": "The directed movement of chloride ions from one side of an epithelium to the other. [GOC:mah]"}
{"concept_id": "C1159593", "aliases": [], "types": ["T043"], "canonical_name": "chromate transport", "definition": "The directed movement of chromate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159594", "aliases": [], "types": ["T043"], "canonical_name": "cyanate transport", "definition": "The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159595", "aliases": ["inorganic pyrophosphate transport"], "types": ["T043"], "canonical_name": "inorganic diphosphate transport", "definition": "The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1159596", "aliases": [], "types": ["T043"], "canonical_name": "iodide transport", "definition": "The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159597", "aliases": [], "types": ["T043"], "canonical_name": "nitrate transport"}
{"concept_id": "C1159598", "aliases": [], "types": ["T043"], "canonical_name": "nitrite transport", "definition": "The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159599", "aliases": ["phosphate transport"], "types": ["T043"], "canonical_name": "phosphate ion transport", "definition": "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159600", "aliases": ["silicate transport", "silicic acid transport"], "types": ["T043"], "canonical_name": "silicic acid import across plasma membrane", "definition": "The directed movement of silicates from outside of a cell, across the plasma membrane and into the cytosol. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. [GOC:ai, GOC:krc, PMID:16572174]"}
{"concept_id": "C1159601", "aliases": ["sulphate transport"], "types": ["T043"], "canonical_name": "sulfate transport", "definition": "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159602", "aliases": ["nucleotide-sulphate transport"], "types": ["T043"], "canonical_name": "nucleotide-sulfate transport", "definition": "The directed movement of nucleotide sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1159603", "aliases": ["sulphite transport"], "types": ["T043"], "canonical_name": "sulfite transport", "definition": "The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159604", "aliases": [], "types": ["T043"], "canonical_name": "tellurite transport", "definition": "The directed movement of tellurite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159605", "aliases": ["thiosulphate transport"], "types": ["T043"], "canonical_name": "thiosulfate transport", "definition": "The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159606", "aliases": [], "types": ["T043"], "canonical_name": "organic anion transport", "definition": "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc]"}
{"concept_id": "C1159607", "aliases": [], "types": ["T043"], "canonical_name": "dicarboxylic acid transport", "definition": "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159608", "aliases": ["2-oxoglutarate transport"], "types": ["T043"], "canonical_name": "alpha-ketoglutarate transport", "definition": "The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159609", "aliases": [], "types": ["T043"], "canonical_name": "C4-dicarboxylate transport", "definition": "The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. [GOC:krc, GOC:mah]"}
{"concept_id": "C1159610", "aliases": [], "types": ["T043"], "canonical_name": "fumarate transport", "definition": "The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159611", "aliases": [], "types": ["T043"], "canonical_name": "malate transport", "definition": "The directed movement of malate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159612", "aliases": ["mitochondrial alpha-ketoglutarate/malate transport"], "types": ["T043"], "canonical_name": "mitochondrial alpha-ketoglutarate/malate transport", "definition": "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion. [GOC:ai]"}
{"concept_id": "C1159613", "aliases": [], "types": ["T043"], "canonical_name": "succinate transport", "definition": "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159614", "aliases": [], "types": ["T043"], "canonical_name": "tartrate transport"}
{"concept_id": "C1159615", "aliases": [], "types": ["T043"], "canonical_name": "hexose phosphate transport", "definition": "The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159616", "aliases": [], "types": ["T043"], "canonical_name": "monocarboxylic acid transport", "definition": "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159617", "aliases": [], "types": ["T043"], "canonical_name": "acetate transport", "definition": "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159618", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane acetate transport", "definition": "The directed movement of acetate across a plasma membrane. [GOC:ai]"}
{"concept_id": "C1159619", "aliases": [], "types": ["T043"], "canonical_name": "allantoate transport", "definition": "The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159620", "aliases": [], "types": ["T043"], "canonical_name": "bile acid transport"}
{"concept_id": "C1159621", "aliases": [], "types": ["T043"], "canonical_name": "canalicular bile acid transport", "definition": "Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:dph]"}
{"concept_id": "C1159622", "aliases": [], "types": ["T043"], "canonical_name": "bilirubin transport", "definition": "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159623", "aliases": [], "types": ["T043"], "canonical_name": "formate transport", "definition": "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159625", "aliases": [], "types": ["T043"], "canonical_name": "L-idonate transport"}
{"concept_id": "C1159626", "aliases": [], "types": ["T043"], "canonical_name": "lactate transport", "definition": "The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1159627", "aliases": [], "types": ["T043"], "canonical_name": "mevalonate transport", "definition": "The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159628", "aliases": [], "types": ["T043"], "canonical_name": "oxaloacetate transport", "definition": "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159629", "aliases": ["propionate transport"], "types": ["T043"], "canonical_name": "propanoate transport", "definition": "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159630", "aliases": ["3-hydroxyphenyl propionate transport"], "types": ["T043"], "canonical_name": "3-hydroxyphenyl propanoate transport", "definition": "The directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159631", "aliases": [], "types": ["T043"], "canonical_name": "prostaglandin transport", "definition": "The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159632", "aliases": [], "types": ["T043"], "canonical_name": "pyruvate transport", "definition": "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159633", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial pyruvate transport"}
{"concept_id": "C1159634", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane pyruvate transport", "definition": "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane. [GOC:ai]"}
{"concept_id": "C1159635", "aliases": [], "types": ["T043"], "canonical_name": "shikimate transport"}
{"concept_id": "C1159636", "aliases": [], "types": ["T043"], "canonical_name": "sialic acid transport", "definition": "The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159637", "aliases": [], "types": ["T043"], "canonical_name": "taurine transport", "definition": "The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159638", "aliases": [], "types": ["T043"], "canonical_name": "uronic acid transport"}
{"concept_id": "C1159639", "aliases": [], "types": ["T043"], "canonical_name": "hexuronate transport"}
{"concept_id": "C1159640", "aliases": [], "types": ["T043"], "canonical_name": "galacturonate transport"}
{"concept_id": "C1159641", "aliases": [], "types": ["T043"], "canonical_name": "glucuronate transport"}
{"concept_id": "C1159642", "aliases": [], "types": ["T043"], "canonical_name": "phosphoenolpyruvate transport", "definition": "The directed movement of phosphoenolpyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159643", "aliases": [], "types": ["T043"], "canonical_name": "phosphoglycerate transport"}
{"concept_id": "C1159644", "aliases": [], "types": ["T043"], "canonical_name": "organic phosphonate transport", "definition": "The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). [GOC:krc]"}
{"concept_id": "C1159645", "aliases": [], "types": ["T043"], "canonical_name": "tricarboxylic acid transport", "definition": "The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159646", "aliases": [], "types": ["T043"], "canonical_name": "citrate transport", "definition": "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159647", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial citrate transport"}
{"concept_id": "C1159648", "aliases": ["aldotriose phosphate transport"], "types": ["T043"], "canonical_name": "triose phosphate transport", "definition": "The directed movement of triose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159649", "aliases": ["uric acid transport", "urate transmembrane transport"], "types": ["T043"], "canonical_name": "urate transport", "definition": "The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C1159650", "aliases": [], "types": ["T043"], "canonical_name": "organophosphate ester transport", "definition": "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. [GOC:mcc]"}
{"concept_id": "C1159651", "aliases": [], "types": ["T044"], "canonical_name": "cation transport", "definition": "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159652", "aliases": [], "types": ["T044"], "canonical_name": "di-, tri-valent inorganic cation transport"}
{"concept_id": "C1159653", "aliases": ["aluminum transport", "aluminum ion transport", "aluminium transport", "aluminium ion transport"], "types": ["T043"], "canonical_name": "aluminum cation transport", "definition": "The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159654", "aliases": ["cadmium transport"], "types": ["T043"], "canonical_name": "cadmium ion transport", "definition": "The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159655", "aliases": ["calcium transport"], "types": ["T043"], "canonical_name": "calcium ion transport", "definition": "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159656", "aliases": ["mitochondrial calcium transport"], "types": ["T043"], "canonical_name": "mitochondrial calcium ion transmembrane transport", "definition": "The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion. [GOC:ai]"}
{"concept_id": "C1159657", "aliases": ["mitochondrial sodium/calcium ion exchange"], "types": ["T043"], "canonical_name": "mitochondrial sodium/calcium ion exchange", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1159658", "aliases": [], "types": ["T043"], "canonical_name": "lead ion transport", "definition": "The directed movement of lead (Pb) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159659", "aliases": [], "types": ["T043"], "canonical_name": "magnesium ion transport", "definition": "The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159660", "aliases": ["mercuric ion transport", "mercury transport"], "types": ["T043"], "canonical_name": "mercury ion transport", "definition": "The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159661", "aliases": ["transition metal transport"], "types": ["T043"], "canonical_name": "transition metal ion transport", "definition": "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [ISBN:0198506732]"}
{"concept_id": "C1159662", "aliases": ["cobalt transport"], "types": ["T043"], "canonical_name": "cobalt ion transport", "definition": "The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159663", "aliases": [], "types": ["T043"], "canonical_name": "copper ion transport", "definition": "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159664", "aliases": ["copper ion uptake"], "types": ["T043"], "canonical_name": "copper ion import", "definition": "The directed movement of copper ions into a cell or organelle. [GOC:ai]"}
{"concept_id": "C1159666", "aliases": ["intracellular copper delivery", "intracellular copper ion transport"], "types": ["T043"], "canonical_name": "protein maturation by copper ion transfer", "definition": "A process that contributes to the delivery of copper ions to a target protein. [GOC:ai]"}
{"concept_id": "C1159667", "aliases": ["plasma membrane copper transport"], "types": ["T043"], "canonical_name": "plasma membrane copper ion transport", "definition": "The directed movement of copper ions across the plasma membrane. [GOC:ai]"}
{"concept_id": "C1159668", "aliases": ["iron transport"], "types": ["T043"], "definition": "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "canonical_name": "iron ion transport"}
{"concept_id": "C1159669", "aliases": [], "types": ["T043"], "canonical_name": "ferric triacetylfusarinine C transport"}
{"concept_id": "C1159670", "aliases": [], "types": ["T043"], "canonical_name": "ferric-enterobactin transport"}
{"concept_id": "C1159671", "aliases": [], "types": ["T043"], "canonical_name": "ferric-hydroxamate transport"}
{"concept_id": "C1159672", "aliases": [], "types": ["T043"], "canonical_name": "iron chelate transport"}
{"concept_id": "C1159674", "aliases": ["ferric ion transport"], "types": ["T043"], "canonical_name": "ferric iron transport"}
{"concept_id": "C1159675", "aliases": ["high-affinity ferric iron transmembrane transport"], "types": ["T043"], "canonical_name": "high affinity ferric iron transport"}
{"concept_id": "C1159676", "aliases": ["ferrous ion transport"], "types": ["T043"], "canonical_name": "ferrous iron transport"}
{"concept_id": "C1159679", "aliases": [], "types": ["T043"], "canonical_name": "manganese ion transport", "definition": "The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159680", "aliases": [], "types": ["T043"], "canonical_name": "molybdate ion transport", "definition": "The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. [GOC:ai]"}
{"concept_id": "C1159681", "aliases": [], "types": ["T043"], "canonical_name": "nickel cation transport", "definition": "The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159682", "aliases": [], "types": ["T043"], "canonical_name": "vanadium ion transport", "definition": "The directed movement of vanadium (V) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159683", "aliases": ["zinc transport", "zinc II ion transport"], "types": ["T043"], "canonical_name": "zinc ion transport", "definition": "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159686", "aliases": [], "types": ["T043"], "canonical_name": "metal ion transport", "definition": "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159687", "aliases": [], "types": ["T043"], "canonical_name": "heavy metal ion transport", "definition": "OBSOLETE. The directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. [GOC:kd, GOC:mah]"}
{"concept_id": "C1159688", "aliases": ["silver transport"], "types": ["T043"], "canonical_name": "silver ion transport", "definition": "The directed movement of silver (Ag) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159689", "aliases": ["potassium transport", "cellular potassium ion transport"], "types": ["T044"], "canonical_name": "potassium ion transport", "definition": "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159690", "aliases": ["sodium transport"], "types": ["T043"], "canonical_name": "sodium ion transport", "definition": "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159692", "aliases": [], "types": ["T043"], "canonical_name": "organic cation transport", "definition": "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. [GOC:ai]"}
{"concept_id": "C1159694", "aliases": ["quaternary amine transport", "quaternary ammonium compound transport"], "types": ["T043"], "canonical_name": "quaternary ammonium group transport", "definition": "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1159695", "aliases": [], "types": ["T043"], "canonical_name": "aminophospholipid transport", "definition": "The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. [GOC:ai]"}
{"concept_id": "C1159696", "aliases": [], "types": ["T043"], "canonical_name": "long-chain fatty acid transport", "definition": "The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [GOC:ai]"}
{"concept_id": "C1159697", "aliases": [], "types": ["T043"], "canonical_name": "carnitine shuttle", "definition": "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine. [ISBN:0198547684]"}
{"concept_id": "C1159698", "aliases": ["peroxisomal long-chain fatty acid uptake", "peroxisomal long-chain fatty acid import"], "types": ["T043"], "canonical_name": "long-chain fatty acid import into peroxisome", "definition": "The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [GOC:ai]"}
{"concept_id": "C1159699", "aliases": ["plasma membrane long-chain fatty acid transport"], "types": ["T043"], "canonical_name": "long-chain fatty acid import across plasma membrane", "definition": "The directed movement of long-chain fatty acids from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [GOC:ai]"}
{"concept_id": "C1159700", "aliases": [], "types": ["T043"], "canonical_name": "medium-chain fatty acid transport", "definition": "The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12. [GOC:ai]"}
{"concept_id": "C1159701", "aliases": [], "types": ["T043"], "canonical_name": "short-chain fatty acid transport", "definition": "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6. [GOC:ai]"}
{"concept_id": "C1159702", "aliases": ["short-chain fatty acid uptake"], "types": ["T043"], "canonical_name": "short-chain fatty acid import", "definition": "The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6. [GOC:ai]"}
{"concept_id": "C1159704", "aliases": ["fatty acyl CoA transport", "fatty acyl-CoA transport", "fatty acyl coenzyme A transport"], "types": ["T043"], "canonical_name": "fatty-acyl-CoA transport", "definition": "The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A). [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1159705", "aliases": ["lipid sequestering", "sequestration of lipid", "sequestering of lipids", "lipid sequestration", "retention of lipids", "lipid retention", "storage of lipids", "lipid storage"], "types": ["T043"], "definition": "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]", "canonical_name": "sequestration of lipids"}
{"concept_id": "C1159706", "aliases": [], "types": ["T043"], "canonical_name": "peroxisomal membrane transport", "definition": "The directed movement of substances to, from or across the peroxisomal membrane. [GOC:ai]"}
{"concept_id": "C1159707", "aliases": [], "types": ["T043"], "canonical_name": "phospholipid transport", "definition": "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. [GOC:ai]"}
{"concept_id": "C1159708", "aliases": [], "types": ["T043"], "canonical_name": "sterol transport", "definition": "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:ai]"}
{"concept_id": "C1159709", "aliases": [], "types": ["T043"], "definition": "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah, ISBN:0198506732]", "canonical_name": "cholesterol transport"}
{"concept_id": "C1159710", "aliases": ["LPS transport"], "types": ["T043"], "canonical_name": "lipopolysaccharide transport", "definition": "The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. [GOC:ai]"}
{"concept_id": "C1159712", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial magnesium ion transport"}
{"concept_id": "C1159713", "aliases": ["murein transport"], "types": ["T043"], "canonical_name": "peptidoglycan transport", "definition": "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159714", "aliases": ["lipid-linked murein transport"], "types": ["T043"], "canonical_name": "lipid-linked peptidoglycan transport", "definition": "The directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1159715", "aliases": [], "types": ["T043"], "canonical_name": "acetylcholine transport", "definition": "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai]"}
{"concept_id": "C1159716", "aliases": [], "types": ["T043"], "canonical_name": "choline transport", "definition": "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:ai]"}
{"concept_id": "C1159717", "aliases": [], "types": ["T043"], "canonical_name": "dopamine transport", "definition": "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:ai]"}
{"concept_id": "C1159718", "aliases": ["levarterenol transport", "noradrenaline transport"], "types": ["T043"], "canonical_name": "norepinephrine transport", "definition": "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1159719", "aliases": [], "types": ["T043"], "canonical_name": "serotonin transport", "definition": "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. [GOC:ai]"}
{"concept_id": "C1159720", "aliases": [], "types": ["T043"], "canonical_name": "nitric oxide transport", "definition": "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1159721", "aliases": [], "types": ["T043"], "canonical_name": "nucleobase, nucleoside, nucleotide and nucleic acid transport"}
{"concept_id": "C1159722", "aliases": ["DNA-protein complex transport"], "types": ["T043"], "canonical_name": "protein-DNA complex transport", "definition": "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159723", "aliases": ["nucleobase transmembrane transport"], "types": ["T043"], "canonical_name": "nucleobase transport", "definition": "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732]"}
{"concept_id": "C1159724", "aliases": ["allantoin transmembrane transport"], "types": ["T043"], "canonical_name": "allantoin transport", "definition": "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159725", "aliases": [], "types": ["T043"], "canonical_name": "purine transport"}
{"concept_id": "C1159726", "aliases": ["adenine transmembrane transport"], "types": ["T043"], "canonical_name": "adenine transport", "definition": "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1159727", "aliases": ["guanine transmembrane transport"], "types": ["T043"], "definition": "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]", "canonical_name": "guanine transport"}
{"concept_id": "C1159728", "aliases": [], "types": ["T043"], "canonical_name": "pyrimidine transport"}
{"concept_id": "C1159729", "aliases": ["cytosine transmembrane transport"], "types": ["T043"], "canonical_name": "cytosine transport", "definition": "The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]"}
{"concept_id": "C1159730", "aliases": [], "types": ["T043"], "canonical_name": "uracil transport", "definition": "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]"}
{"concept_id": "C1159731", "aliases": [], "types": ["T043"], "canonical_name": "nucleoside transport", "definition": "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159732", "aliases": [], "types": ["T043"], "canonical_name": "intracellular nucleoside transport", "definition": "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell. [GOC:ai]"}
{"concept_id": "C1159733", "aliases": [], "types": ["T043"], "canonical_name": "purine nucleoside transport"}
{"concept_id": "C1159734", "aliases": [], "types": ["T043"], "canonical_name": "xanthosine transport", "definition": "The directed movement of xanthosine, xanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732]"}
{"concept_id": "C1159735", "aliases": [], "types": ["T043"], "canonical_name": "pyrimidine nucleoside transport", "definition": "The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159736", "aliases": [], "types": ["T043"], "canonical_name": "cytidine transport", "definition": "The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]"}
{"concept_id": "C1159737", "aliases": [], "types": ["T043"], "canonical_name": "uridine transport", "definition": "The directed movement of uridine, uracil riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]"}
{"concept_id": "C1159738", "aliases": [], "types": ["T043"], "canonical_name": "nucleotide transport", "definition": "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. [ISBN:0198506732]"}
{"concept_id": "C1159739", "aliases": [], "types": ["T043"], "canonical_name": "deoxynucleotide transport", "definition": "The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1159740", "aliases": [], "types": ["T043"], "canonical_name": "purine nucleotide transport", "definition": "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. [GOC:ai]"}
{"concept_id": "C1159741", "aliases": [], "types": ["T043"], "canonical_name": "ADP transport", "definition": "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159743", "aliases": [], "types": ["T043"], "canonical_name": "ATP transport", "definition": "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159744", "aliases": [], "types": ["T043"], "canonical_name": "purine ribonucleotide transport", "definition": "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell. [GOC:ai]"}
{"concept_id": "C1159745", "aliases": [], "types": ["T043"], "canonical_name": "pyrimidine nucleotide transport", "definition": "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. [GOC:ai]"}
{"concept_id": "C1159746", "aliases": ["one carbon compound transport"], "types": ["T043"], "canonical_name": "one-carbon compound transport", "definition": "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159747", "aliases": ["oxalic acid transport", "ethanedioic acid transport", "ethanedioate transport"], "types": ["T043"], "canonical_name": "oxalate transport", "definition": "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. [ISBN:0198506732]"}
{"concept_id": "C1159748", "aliases": ["organic alcohol transport"], "types": ["T043"], "canonical_name": "organic hydroxy compound transport", "definition": "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. [GOC:ai]"}
{"concept_id": "C1159749", "aliases": [], "types": ["T043"], "canonical_name": "polyol transmembrane transport", "definition": "The directed movement of polyols, any polyhydric alcohol, across a membrane. [GOC:ai]"}
{"concept_id": "C1159750", "aliases": ["arabitol transport"], "types": ["T043"], "canonical_name": "arabinitol transport"}
{"concept_id": "C1159751", "aliases": [], "types": ["T043"], "canonical_name": "galactitol transport"}
{"concept_id": "C1159752", "aliases": ["glucitol transport", "sorbitol transport"], "types": ["T043"], "canonical_name": "sorbitol transmembrane transport", "definition": "The directed movement of sorbitol across a membrane. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1159753", "aliases": [], "types": ["T043"], "canonical_name": "glycerol transport"}
{"concept_id": "C1159754", "aliases": [], "types": ["T043"], "canonical_name": "glycerol-3-phosphate transport"}
{"concept_id": "C1159755", "aliases": [], "types": ["T043"], "canonical_name": "mannitol transport"}
{"concept_id": "C1159756", "aliases": ["vitamin Bh transport"], "types": ["T043"], "canonical_name": "myo-inositol transport", "definition": "The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. [GOC:ai]"}
{"concept_id": "C1159757", "aliases": [], "types": ["T043"], "canonical_name": "propanediol transport", "definition": "The directed movement of propanediol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects. [http://www.rhymezone.com]"}
{"concept_id": "C1159762", "aliases": [], "types": ["T043"], "definition": "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149]", "canonical_name": "opsonization"}
{"concept_id": "C1159764", "aliases": [], "types": ["T043"], "canonical_name": "phagocytosis, engulfment", "definition": "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. [GOC:curators, ISBN:0781735149]"}
{"concept_id": "C1159765", "aliases": [], "types": ["T043"], "canonical_name": "phagosome formation", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:hjd]"}
{"concept_id": "C1159766", "aliases": ["clathrin-independent pinocytosis"], "types": ["T043"], "canonical_name": "clathrin-independent pinocytosis"}
{"concept_id": "C1159767", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endocytosis", "definition": "Any process that modulates the frequency, rate or extent of endocytosis. [GOC:go_curators]"}
{"concept_id": "C1159768", "aliases": ["down-regulation of endocytosis", "down regulation of endocytosis", "downregulation of endocytosis"], "types": ["T043"], "canonical_name": "negative regulation of endocytosis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. [GOC:go_curators]"}
{"concept_id": "C1159769", "aliases": ["up-regulation of endocytosis", "upregulation of endocytosis", "up regulation of endocytosis"], "types": ["T043"], "canonical_name": "positive regulation of endocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of endocytosis. [GOC:go_curators]"}
{"concept_id": "C1159770", "aliases": ["receptor mediated endocytosis by host of virus particle", "virus receptor-mediated endocytosis by host", "receptor-mediated endocytosis of virus by host", "viral entry into host cell via receptor-mediated endocytosis", "receptor mediated endocytosis of virus by host", "viral receptor mediated endocytosis", "receptor mediated endocytosis of virus particle by host"], "types": ["T043"], "canonical_name": "receptor-mediated endocytosis of virus by host cell", "definition": "Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell. [GOC:bf, GOC:jl, ISBN:0781702534]"}
{"concept_id": "C1159772", "aliases": [], "types": ["T043"], "definition": "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. [GOC:mah]", "canonical_name": "intracellular protein transport"}
{"concept_id": "C1159773", "aliases": ["intracellular protein transport in host", "host cell protein transport"], "types": ["T043"], "canonical_name": "symbiont intracellular protein transport in host", "definition": "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mb]"}
{"concept_id": "C1159774", "aliases": ["intracellular viral protein transport", "intracellular transport of viral proteins in host cell"], "types": ["T043"], "canonical_name": "intracellular transport of viral protein in host cell", "definition": "The directed movement of a viral protein within the host cell. [GOC:ai, ISBN:0781702534, ISBN:0781718325, PMID:11581394, PMID:9188566]"}
{"concept_id": "C1159777", "aliases": [], "types": ["T043"], "definition": "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "canonical_name": "peptide transport"}
{"concept_id": "C1159778", "aliases": ["muropeptide transport", "murein peptide transport", "peptidoglycan peptide transport"], "types": ["T043"], "canonical_name": "peptidoglycan-associated peptide transport", "definition": "The directed movement of peptidoglycan peptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains. [ISBN:0198506732]"}
{"concept_id": "C1159779", "aliases": [], "types": ["T043"], "canonical_name": "oligopeptide transport", "definition": "The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [ISBN:0198506732]"}
{"concept_id": "C1159780", "aliases": ["peptide pheromone secretion"], "types": ["T043"], "canonical_name": "peptide pheromone export", "definition": "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones. [GOC:elh]"}
{"concept_id": "C1159781", "aliases": ["iron-siderophore transport", "siderophore-iron transport"], "types": ["T043"], "canonical_name": "siderophore transport", "definition": "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159783", "aliases": [], "types": ["T043"], "canonical_name": "solute:solute exchange", "definition": "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction. [GOC:mah]"}
{"concept_id": "C1159784", "aliases": ["sodium:calcium exchange"], "types": ["T043"], "canonical_name": "sodium:calcium exchange", "definition": "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1159786", "aliases": [], "types": ["T043"], "canonical_name": "nonselective vesicle transport"}
{"concept_id": "C1159788", "aliases": ["viral transport", "virion transport"], "types": ["T043"], "canonical_name": "transport of virus", "definition": "The directed movement of a virus, or part of a virus, into, out of, or within a host cell. [GOC:ai]"}
{"concept_id": "C1159789", "aliases": [], "types": ["T043"], "canonical_name": "intracellular virion transport"}
{"concept_id": "C1159790", "aliases": [], "types": ["T043"], "canonical_name": "vitamin or cofactor transport", "definition": "OBSOLETE. The directed movement of vitamins or cofactors into, out of or within a cell, or between cells. [GOC:ai]"}
{"concept_id": "C1159791", "aliases": [], "types": ["T043"], "canonical_name": "acetyl-CoA transport", "definition": "The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. [GOC:ai]"}
{"concept_id": "C1159792", "aliases": [], "types": ["T043"], "canonical_name": "biopterin transport", "definition": "The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme. [GOC:ai]"}
{"concept_id": "C1159793", "aliases": ["vitamin H transport", "vitamin B7 transport"], "types": ["T043"], "canonical_name": "biotin transport", "definition": "The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. [GOC:ai]"}
{"concept_id": "C1159794", "aliases": ["Vitamin BT transport", "vitamin Bt transport", "Carnitine transport"], "types": ["T043"], "canonical_name": "carnitine transport", "definition": "The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:ai]"}
{"concept_id": "C1159795", "aliases": [], "types": ["T043"], "canonical_name": "acyl carnitine transport", "definition": "The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane. [GOC:ai]"}
{"concept_id": "C1159796", "aliases": [], "types": ["T043"], "canonical_name": "coenzyme A transport", "definition": "The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [GOC:ai]"}
{"concept_id": "C1159797", "aliases": [], "types": ["T043"], "canonical_name": "creatine transport"}
{"concept_id": "C1159798", "aliases": ["flavin adenine dinucleotide transport", "flavin-adenine dinucleotide transport"], "types": ["T043"], "canonical_name": "FAD transport", "definition": "The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. [ISBN:0198506732]"}
{"concept_id": "C1159799", "aliases": ["vitamin B9 transport", "folate transport", "vitamin M transport"], "types": ["T043"], "canonical_name": "folic acid transport", "definition": "The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:ai]"}
{"concept_id": "C1159800", "aliases": [], "types": ["T043"], "canonical_name": "5-formyltetrahydrofolate transport", "definition": "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159801", "aliases": ["haem transport"], "types": ["T043"], "canonical_name": "heme transport", "definition": "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159802", "aliases": ["L-ascorbic acid transport", "L-ascorbate transport", "vitamin C transport"], "types": ["T043"], "canonical_name": "L-ascorbic acid transmembrane transport", "definition": "The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species. [GOC:ai]"}
{"concept_id": "C1159803", "aliases": ["nicotinamide ribonucleotide transport"], "types": ["T043"], "canonical_name": "nicotinamide mononucleotide transport", "definition": "The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP. [ISBN:0721662544]"}
{"concept_id": "C1159804", "aliases": ["pantothenate transport", "vitamin B5 transport", "pantothenate membrane transport"], "types": ["T043"], "canonical_name": "pantothenate transmembrane transport", "definition": "The process in which pantothenate is transported across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. [GOC:ai, ISBN:0721662544]"}
{"concept_id": "C1159805", "aliases": ["vitamin B1 transport", "thiamin transport"], "types": ["T043"], "canonical_name": "thiamine transport", "definition": "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:ai]"}
{"concept_id": "C1159806", "aliases": ["vitamin B12 transport"], "types": ["T043"], "canonical_name": "cobalamin transport", "definition": "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1159807", "aliases": ["NK cell mediated cell killing", "NK cell mediated cell death", "natural killer cell mediated cytotoxicity", "natural killer cell mediated cell death", "NK cell mediated cytotoxicity"], "types": ["T043"], "definition": "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, GOC:pr]", "canonical_name": "natural killer cell mediated cell killing"}
{"concept_id": "C1159808", "aliases": ["regulation of natural killer cell mediated cell death", "regulation of NK cell mediated cytotoxicity", "regulation of NK cell mediated cell death", "regulation of NK cell mediated cell killing", "regulation of natural killer cell mediated cell killing"], "types": ["T043"], "canonical_name": "regulation of natural killer cell mediated cytotoxicity", "definition": "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1159809", "aliases": ["downregulation of natural killer cell mediated cytotoxicity", "negative regulation of natural killer cell mediated cell death", "down-regulation of natural killer cell mediated cytotoxicity", "negative regulation of natural killer cell mediated cell killing", "negative regulation of NK cell mediated cytotoxicity", "negative regulation of NK cell mediated cell death", "down regulation of natural killer cell mediated cytotoxicity", "negative regulation of NK cell mediated cell killing"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell mediated cytotoxicity", "definition": "Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1159810", "aliases": ["positive regulation of natural killer cell mediated cell death", "up-regulation of natural killer cell mediated cytotoxicity", "positive regulation of natural killer cell mediated cell killing", "upregulation of natural killer cell mediated cytotoxicity", "positive regulation of NK cell mediated cytotoxicity", "up regulation of natural killer cell mediated cytotoxicity", "positive regulation of NK cell mediated cell death", "positive regulation of NK cell mediated cell killing"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell mediated cytotoxicity", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1159811", "aliases": ["protection from NK cell mediated cell death", "protection from natural killer cell mediated cell killing", "protection from natural killer cell mediated cell death", "protection from NK cell mediated cytotoxicity", "protection from NK cell mediated cell killing"], "types": ["T043"], "canonical_name": "protection from natural killer cell mediated cytotoxicity", "definition": "The process of protecting a cell from natural killer cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1159812", "aliases": ["susceptibility to NK cell mediated cell death", "susceptibility to NK cell mediated cell killing", "susceptibility to NK cell mediated cytolysis", "susceptibility to natural killer cell mediated cytolysis", "susceptibility to NK cell mediated cytotoxicity", "susceptibility to natural killer cell mediated cell killing", "susceptibility to natural killer cell mediated cell death"], "types": ["T043"], "canonical_name": "susceptibility to natural killer cell mediated cytotoxicity", "definition": "The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1159813", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytolysis", "definition": "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm. [GOC:jl, GOC:mtg_apoptosis]"}
{"concept_id": "C1159814", "aliases": ["down-regulation of cytolysis", "downregulation of cytolysis", "down regulation of cytolysis"], "types": ["T043"], "canonical_name": "negative regulation of cytolysis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis. [GOC:go_curators]"}
{"concept_id": "C1159815", "aliases": ["upregulation of cytolysis", "up regulation of cytolysis", "up-regulation of cytolysis"], "types": ["T043"], "canonical_name": "positive regulation of cytolysis", "definition": "Any process that activates or increases the frequency, rate or extent of cytolysis. [GOC:go_curators]"}
{"concept_id": "C1159817", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of caspase activation"}
{"concept_id": "C1159821", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic program"}
{"concept_id": "C1159822", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic mitochondrial changes", "definition": "The morphological and physiological alterations undergone by mitochondria during apoptosis. [GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C1159823", "aliases": ["apoptotic nuclear change"], "types": ["T043"], "canonical_name": "apoptotic nuclear changes", "definition": "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. [GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C1159825", "aliases": ["activation of cysteine-type endopeptidase activity involved in apoptotic process", "caspase activation"], "types": ["T044"], "definition": "Caspase Activation involves induction of the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface proteins (BcL-2 Family) and involved in initial signaling and downstream proteolytic cleavages (at P1 aspartic acids) in inflammation and apoptotic cell death when signals block BcL-2 function and activators initiate caspase cascades.", "canonical_name": "activation of caspase activity"}
{"concept_id": "C1159826", "aliases": ["caspase activation via cytochrome c"], "types": ["T044"], "canonical_name": "activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c", "definition": "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c. [GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, Wikipedia:Caspase]"}
{"concept_id": "C1159828", "aliases": [], "types": ["T043"], "canonical_name": "disassembly of cell structures"}
{"concept_id": "C1159837", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis by granzyme"}
{"concept_id": "C1159838", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis by hormones"}
{"concept_id": "C1159839", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis by ionic changes"}
{"concept_id": "C1159840", "aliases": ["induction of apoptosis via death receptors", "induction of apoptosis via death domain receptors"], "types": ["T043"], "canonical_name": "extrinsic apoptotic signaling pathway via death domain receptors", "definition": "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. [GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C1159841", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis by intracellular signals"}
{"concept_id": "C1159842", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis by oxidative stress"}
{"concept_id": "C1159843", "aliases": ["programmed cell death, inflammatory cells", "programmed cell death of inflammatory cells by apoptosis", "inflammatory cell programmed cell death by apoptosis", "apoptosis of inflammatory cells", "killing of inflammatory cells", "inflammatory cell apoptosis"], "types": ["T043"], "canonical_name": "inflammatory cell apoptotic process", "definition": "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. [GOC:jl, GOC:mtg_apoptosis]"}
{"concept_id": "C1159846", "aliases": ["apoptosis of nurse cells", "nurse cell programmed cell death by apoptosis", "programmed cell death of nurse cells by apoptosis", "nurse cell apoptosis"], "types": ["T043"], "canonical_name": "nurse cell apoptotic process", "definition": "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process. [CL:0000026, GOC:mtg_apoptosis, PMID:11973306]"}
{"concept_id": "C1159847", "aliases": ["regulation of nurse cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of nurse cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of nurse cell apoptotic process. [GOC:mtg_apoptosis, PMID:11973306]"}
{"concept_id": "C1159849", "aliases": ["up regulation of nurse cell apoptosis", "positive regulation of nurse cell apoptosis", "up-regulation of nurse cell apoptosis", "upregulation of nurse cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of nurse cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process. [GOC:go_curators, GOC:mtg_apoptosis]"}
{"concept_id": "C1159850", "aliases": ["activated T cell apoptosis"], "types": ["T043"], "canonical_name": "activated T cell apoptosis"}
{"concept_id": "C1159851", "aliases": [], "types": ["T043"], "canonical_name": "induction of programmed cell death", "definition": "A process which directly activates any of the steps required for programmed cell death. [GOC:lr]"}
{"concept_id": "C1159852", "aliases": ["induction of nonapoptotic programmed cell death"], "types": ["T043"], "canonical_name": "induction of non-apoptotic programmed cell death"}
{"concept_id": "C1159853", "aliases": [], "types": ["T043"], "canonical_name": "induction of retinal programmed cell death"}
{"concept_id": "C1159856", "aliases": ["programmed cell death, retina cells", "programmed cell death, retinal cells", "retinal programmed cell death", "retina cell programmed cell death", "retina programmed cell death"], "types": ["T043"], "canonical_name": "retinal cell programmed cell death", "definition": "Programmed cell death that occurs in the developing retina. [GOC:bf]"}
{"concept_id": "C1159857", "aliases": ["regulation of retinal programmed cell death", "regulation of retinal cell programmed cell death"], "types": ["T043"], "canonical_name": "regulation of retinal cell programmed cell death", "definition": "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. [GOC:ai, GOC:tb]"}
{"concept_id": "C1159858", "aliases": ["downregulation of retinal cell programmed cell death", "negative regulation of retina cell programmed cell death", "negative regulation of retinal programmed cell death", "inhibition of retinal cell programmed cell death", "down regulation of retinal programmed cell death", "down-regulation of retinal programmed cell death", "down-regulation of retinal cell programmed cell death", "down regulation of retinal cell programmed cell death", "downregulation of retinal programmed cell death", "negative regulation of retinal cell programmed cell death"], "types": ["T043"], "canonical_name": "negative regulation of retinal cell programmed cell death", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. [GOC:ai, GOC:tb]"}
{"concept_id": "C1159860", "aliases": ["up regulation of retinal cell programmed cell death", "stimulation of retinal cell programmed cell death", "up-regulation of retinal programmed cell death", "activation of retinal cell programmed cell death", "positive regulation of retinal programmed cell death", "positive regulation of retinal cell programmed cell death", "upregulation of retinal programmed cell death", "upregulation of retinal cell programmed cell death", "up regulation of retinal programmed cell death", "up-regulation of retinal cell programmed cell death"], "types": ["T043"], "canonical_name": "positive regulation of retinal cell programmed cell death", "definition": "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. [GOC:ai, GOC:tb]"}
{"concept_id": "C1159884", "aliases": ["adipocyte cell differentiation", "adipose cell differentiation", "adipocyte differentiation"], "types": ["T043"], "canonical_name": "fat cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. [CL:0000136, GOC:go_curators]"}
{"concept_id": "C1159885", "aliases": ["regulation of adipocyte differentiation", "regulation of adipocyte cell differentiation"], "types": ["T043"], "canonical_name": "regulation of fat cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159886", "aliases": ["down regulation of fat cell differentiation", "downregulation of fat cell differentiation", "down-regulation of fat cell differentiation", "negative regulation of adipocyte differentiation", "negative regulation of adipocyte cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of fat cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159887", "aliases": ["upregulation of fat cell differentiation", "positive regulation of adipocyte cell differentiation", "up regulation of fat cell differentiation", "up-regulation of fat cell differentiation", "positive regulation of adipocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of fat cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159888", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell differentiation", "definition": "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. [CL:0000115, GOC:go_curators]"}
{"concept_id": "C1159889", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelial cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of endothelial cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1159890", "aliases": ["downregulation of endothelial cell differentiation", "down-regulation of endothelial cell differentiation", "down regulation of endothelial cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1159891", "aliases": ["up-regulation of endothelial cell differentiation", "upregulation of endothelial cell differentiation", "up regulation of endothelial cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of endothelial cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1159892", "aliases": [], "types": ["T042"], "canonical_name": "epidermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C1159893", "aliases": ["auditory receptor cell differentiation", "auditory hair cell differentiation"], "types": ["T043"], "canonical_name": "inner ear auditory receptor cell differentiation", "definition": "The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell. [CL:0000201, GOC:jl]"}
{"concept_id": "C1159894", "aliases": ["regulation of auditory receptor cell differentiation", "regulation of auditory hair cell differentiation"], "types": ["T043"], "canonical_name": "regulation of inner ear auditory receptor cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1159895", "aliases": ["down regulation of auditory receptor cell differentiation", "negative regulation of auditory hair cell differentiation", "down-regulation of auditory receptor cell differentiation", "negative regulation of auditory receptor cell differentiation", "downregulation of auditory receptor cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of inner ear auditory receptor cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1159896", "aliases": ["upregulation of auditory receptor cell differentiation", "up-regulation of auditory receptor cell differentiation", "positive regulation of auditory hair cell differentiation", "up regulation of auditory receptor cell differentiation", "positive regulation of auditory receptor cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of inner ear auditory receptor cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1159897", "aliases": ["auditory hair cell fate commitment"], "types": ["T043"], "canonical_name": "auditory receptor cell fate commitment", "definition": "The process in which the cellular identity of auditory hair cells is acquired and determined. [GOC:lr]"}
{"concept_id": "C1159898", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epidermal cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of epidermal cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1159899", "aliases": ["down regulation of epidermal cell differentiation", "down-regulation of epidermal cell differentiation", "downregulation of epidermal cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of epidermal cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1159900", "aliases": ["upregulation of epidermal cell differentiation", "up-regulation of epidermal cell differentiation", "up regulation of epidermal cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of epidermal cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1159902", "aliases": [], "types": ["T043"], "canonical_name": "plasmatocyte differentiation", "definition": "The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response. [PMID:11921077, PMID:8174791]"}
{"concept_id": "C1159903", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plasmatocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of plasmatocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159904", "aliases": ["down regulation of plasmatocyte differentiation", "downregulation of plasmatocyte differentiation", "down-regulation of plasmatocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of plasmatocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159905", "aliases": ["up-regulation of plasmatocyte differentiation", "upregulation of plasmatocyte differentiation", "up regulation of plasmatocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of plasmatocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159906", "aliases": ["regulation of arthropod blood cell differentiation"], "types": ["T043"], "canonical_name": "regulation of hemocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of hemocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159907", "aliases": ["downregulation of hemocyte differentiation", "down-regulation of hemocyte differentiation", "negative regulation of arthropod blood cell differentiation", "down regulation of hemocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of hemocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159908", "aliases": ["upregulation of hemocyte differentiation", "positive regulation of arthropod blood cell differentiation", "up-regulation of hemocyte differentiation", "up regulation of hemocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of hemocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of hemocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159909", "aliases": ["keratinocyte cell differentiation"], "types": ["T043"], "definition": "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]", "canonical_name": "keratinocyte differentiation"}
{"concept_id": "C1159910", "aliases": [], "types": ["T043"], "canonical_name": "regulation of keratinocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of keratinocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159911", "aliases": ["downregulation of keratinocyte differentiation", "down-regulation of keratinocyte differentiation", "down regulation of keratinocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of keratinocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159912", "aliases": ["up-regulation of keratinocyte differentiation", "upregulation of keratinocyte differentiation", "up regulation of keratinocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of keratinocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159914", "aliases": ["lymphocytic blood cell differentiation", "lymphocyte cell differentiation"], "types": ["T043"], "definition": "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. [CL:0000542, GOC:go_curators]", "canonical_name": "lymphocyte differentiation"}
{"concept_id": "C1159915", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lymphocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of lymphocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159916", "aliases": ["down-regulation of lymphocyte differentiation", "down regulation of lymphocyte differentiation", "downregulation of lymphocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of lymphocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159917", "aliases": ["up-regulation of lymphocyte differentiation", "up regulation of lymphocyte differentiation", "upregulation of lymphocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of lymphocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159918", "aliases": ["T-cell selection", "T lymphocyte selection", "T-lymphocyte selection"], "types": ["T043"], "canonical_name": "T cell selection", "definition": "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. [ISBN:0781735149, PMID:12414722]"}
{"concept_id": "C1159919", "aliases": ["extrathymic T-lymphocyte selection", "extrathymic T-cell selection", "extrathymic T lymphocyte selection"], "types": ["T043"], "canonical_name": "extrathymic T cell selection", "definition": "The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus. [ISBN:0781735149, PMID:7880383]"}
{"concept_id": "C1159920", "aliases": ["negative extrathymic T-cell selection", "negative extrathymic T lymphocyte selection", "negative extrathymic T-lymphocyte selection"], "types": ["T043"], "canonical_name": "negative extrathymic T cell selection", "definition": "The process of elimination of extrathymically maturing T cells which react strongly with self-antigens. [ISBN:0781735149, PMID:7880383]"}
{"concept_id": "C1159921", "aliases": ["positive extrathymic T-lymphocyte selection", "positive extrathymic T-cell selection", "positive extrathymic T lymphocyte selection"], "types": ["T043"], "canonical_name": "positive extrathymic T cell selection", "definition": "The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. [ISBN:0781735149, PMID:7880383]"}
{"concept_id": "C1159923", "aliases": ["negative thymic T-lymphocyte selection", "negative thymic T-cell selection", "negative thymic T lymphocyte selection"], "types": ["T043"], "canonical_name": "negative thymic T cell selection", "definition": "The process of elimination of immature T cells in the thymus which react strongly with self-antigens. [ISBN:0781735149, PMID:12414722]"}
{"concept_id": "C1159924", "aliases": ["positive thymic T-lymphocyte selection", "positive thymic T lymphocyte selection", "positive thymic T-cell selection"], "types": ["T043"], "canonical_name": "positive thymic T cell selection", "definition": "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death. [ISBN:0781735149, PMID:12414722]"}
{"concept_id": "C1159925", "aliases": [], "types": ["T043"], "canonical_name": "mechanoreceptor differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. [CL:0000199, GOC:jl]"}
{"concept_id": "C1159926", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mechanoreceptor differentiation", "definition": "Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation. [GOC:go_curators]"}
{"concept_id": "C1159927", "aliases": ["down regulation of mechanoreceptor differentiation", "down-regulation of mechanoreceptor differentiation", "downregulation of mechanoreceptor differentiation"], "types": ["T043"], "canonical_name": "negative regulation of mechanoreceptor differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation. [GOC:go_curators]"}
{"concept_id": "C1159928", "aliases": ["up regulation of mechanoreceptor differentiation", "upregulation of mechanoreceptor differentiation", "up-regulation of mechanoreceptor differentiation"], "types": ["T043"], "canonical_name": "positive regulation of mechanoreceptor differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation. [GOC:go_curators]"}
{"concept_id": "C1159929", "aliases": ["melanophore differentiation", "melanocyte cell differentiation"], "types": ["T043"], "canonical_name": "melanocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. [GOC:mah]"}
{"concept_id": "C1159930", "aliases": ["regulation of melanophore differentiation"], "types": ["T043"], "canonical_name": "regulation of melanocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of melanocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159931", "aliases": ["down-regulation of melanocyte differentiation", "downregulation of melanocyte differentiation", "negative regulation of melanophore differentiation", "down regulation of melanocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of melanocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159932", "aliases": ["up-regulation of melanocyte differentiation", "positive regulation of melanophore differentiation", "upregulation of melanocyte differentiation", "up regulation of melanocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of melanocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159934", "aliases": ["basophil cell differentiation"], "types": ["T043"], "canonical_name": "basophil differentiation", "definition": "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell. [GOC:jid, GOC:mah]"}
{"concept_id": "C1159935", "aliases": [], "types": ["T043"], "canonical_name": "regulation of basophil differentiation", "definition": "Any process that modulates the frequency, rate or extent of basophil differentiation. [GOC:go_curators]"}
{"concept_id": "C1159936", "aliases": ["downregulation of basophil differentiation", "down-regulation of basophil differentiation", "down regulation of basophil differentiation"], "types": ["T043"], "canonical_name": "negative regulation of basophil differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation. [GOC:go_curators]"}
{"concept_id": "C1159937", "aliases": ["up-regulation of basophil differentiation", "upregulation of basophil differentiation", "up regulation of basophil differentiation"], "types": ["T043"], "canonical_name": "positive regulation of basophil differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of basophil differentiation. [GOC:go_curators]"}
{"concept_id": "C1159938", "aliases": ["eosinophil cell differentiation"], "types": ["T043"], "canonical_name": "eosinophil differentiation", "definition": "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil. [GOC:add, GOC:mah]"}
{"concept_id": "C1159939", "aliases": [], "types": ["T043"], "canonical_name": "regulation of eosinophil differentiation", "definition": "Any process that modulates the frequency, rate or extent of eosinophil differentiation. [GOC:go_curators]"}
{"concept_id": "C1159940", "aliases": ["downregulation of eosinophil differentiation", "down regulation of eosinophil differentiation", "down-regulation of eosinophil differentiation"], "types": ["T043"], "canonical_name": "negative regulation of eosinophil differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation. [GOC:go_curators]"}
{"concept_id": "C1159941", "aliases": ["up-regulation of eosinophil differentiation", "upregulation of eosinophil differentiation", "up regulation of eosinophil differentiation"], "types": ["T043"], "canonical_name": "positive regulation of eosinophil differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of eosinophil differentiation. [GOC:go_curators]"}
{"concept_id": "C1159943", "aliases": ["regulation of RBC differentiation", "regulation of red blood cell differentiation"], "types": ["T043"], "canonical_name": "regulation of erythrocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of erythrocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159944", "aliases": ["negative regulation of red blood cell differentiation", "down regulation of erythrocyte differentiation", "down-regulation of erythrocyte differentiation", "downregulation of erythrocyte differentiation", "negative regulation of RBC differentiation"], "types": ["T043"], "canonical_name": "negative regulation of erythrocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159945", "aliases": ["up regulation of erythrocyte differentiation", "upregulation of erythrocyte differentiation", "positive regulation of RBC differentiation", "up-regulation of erythrocyte differentiation", "positive regulation of red blood cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of erythrocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159946", "aliases": ["macrophage differentiation"], "types": ["T043"], "definition": "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. [GOC:add, ISBN:0781735149]", "canonical_name": "macrophage cell differentiation"}
{"concept_id": "C1159947", "aliases": [], "types": ["T043"], "canonical_name": "regulation of macrophage differentiation", "definition": "Any process that modulates the frequency, rate or extent of macrophage differentiation. [GOC:go_curators]"}
{"concept_id": "C1159948", "aliases": ["down-regulation of macrophage differentiation", "downregulation of macrophage differentiation", "down regulation of macrophage differentiation"], "types": ["T043"], "canonical_name": "negative regulation of macrophage differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation. [GOC:go_curators]"}
{"concept_id": "C1159949", "aliases": ["up-regulation of macrophage differentiation", "upregulation of macrophage differentiation", "up regulation of macrophage differentiation"], "types": ["T043"], "canonical_name": "positive regulation of macrophage differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of macrophage differentiation. [GOC:go_curators]"}
{"concept_id": "C1159950", "aliases": ["megakaryocyte differentiation"], "types": ["T043"], "definition": "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. [GOC:mah]", "canonical_name": "megakaryocyte cell differentiation"}
{"concept_id": "C1159951", "aliases": [], "types": ["T043"], "canonical_name": "regulation of megakaryocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159952", "aliases": ["downregulation of megakaryocyte differentiation", "down-regulation of megakaryocyte differentiation", "down regulation of megakaryocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of megakaryocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159953", "aliases": ["up-regulation of megakaryocyte differentiation", "up regulation of megakaryocyte differentiation", "upregulation of megakaryocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of megakaryocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159954", "aliases": ["monocyte cell differentiation"], "types": ["T043"], "canonical_name": "monocyte differentiation", "definition": "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. [GOC:mah]"}
{"concept_id": "C1159955", "aliases": [], "types": ["T043"], "canonical_name": "regulation of monocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of monocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159956", "aliases": ["downregulation of monocyte differentiation", "down regulation of monocyte differentiation", "down-regulation of monocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of monocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159957", "aliases": ["upregulation of monocyte differentiation", "up-regulation of monocyte differentiation", "up regulation of monocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of monocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of monocyte differentiation. [GOC:go_curators]"}
{"concept_id": "C1159958", "aliases": ["neutrophil granulocytopoiesis", "neutrophil cell differentiation", "neutrophil granulocyte differentiation"], "types": ["T043"], "canonical_name": "neutrophil differentiation", "definition": "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil. [GOC:mah]"}
{"concept_id": "C1159959", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil differentiation", "definition": "Any process that modulates the frequency, rate or extent of neutrophil differentiation. [GOC:go_curators]"}
{"concept_id": "C1159960", "aliases": ["down regulation of neutrophil differentiation", "downregulation of neutrophil differentiation", "down-regulation of neutrophil differentiation"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation. [GOC:go_curators]"}
{"concept_id": "C1159961", "aliases": ["up-regulation of neutrophil differentiation", "up regulation of neutrophil differentiation", "upregulation of neutrophil differentiation"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of neutrophil differentiation. [GOC:go_curators]"}
{"concept_id": "C1159962", "aliases": ["platelet extrusion"], "types": ["T043"], "definition": "The process in which platelets bud from long processes extended by megakaryocytes. [GOC:mah, ISBN:0815316194]", "canonical_name": "platelet formation"}
{"concept_id": "C1159966", "aliases": ["myoblast cell differentiation"], "types": ["T043"], "canonical_name": "myoblast differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]"}
{"concept_id": "C1159967", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myoblast differentiation", "definition": "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]"}
{"concept_id": "C1159968", "aliases": ["down-regulation of myoblast differentiation", "down regulation of myoblast differentiation", "downregulation of myoblast differentiation"], "types": ["T043"], "canonical_name": "negative regulation of myoblast differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]"}
{"concept_id": "C1159969", "aliases": ["up-regulation of myoblast differentiation", "upregulation of myoblast differentiation", "up regulation of myoblast differentiation"], "types": ["T043"], "canonical_name": "positive regulation of myoblast differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]"}
{"concept_id": "C1159970", "aliases": [], "types": ["T043"], "canonical_name": "neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]"}
{"concept_id": "C1159971", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neuron differentiation", "definition": "Any process that modulates the frequency, rate or extent of neuron differentiation. [GOC:go_curators]"}
{"concept_id": "C1159972", "aliases": ["down regulation of neuron differentiation", "downregulation of neuron differentiation", "down-regulation of neuron differentiation"], "types": ["T043"], "canonical_name": "negative regulation of neuron differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. [GOC:go_curators]"}
{"concept_id": "C1159973", "aliases": ["up-regulation of neuron differentiation", "up regulation of neuron differentiation", "upregulation of neuron differentiation"], "types": ["T043"], "canonical_name": "positive regulation of neuron differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of neuron differentiation. [GOC:go_curators]"}
{"concept_id": "C1159974", "aliases": ["osteoblast cell differentiation"], "types": ["T043"], "canonical_name": "osteoblast differentiation", "definition": "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid]"}
{"concept_id": "C1159975", "aliases": [], "types": ["T043"], "canonical_name": "regulation of osteoblast differentiation", "definition": "Any process that modulates the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]"}
{"concept_id": "C1159976", "aliases": ["down-regulation of osteoblast differentiation", "downregulation of osteoblast differentiation", "down regulation of osteoblast differentiation"], "types": ["T043"], "canonical_name": "negative regulation of osteoblast differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]"}
{"concept_id": "C1159977", "aliases": ["up-regulation of osteoblast differentiation", "up regulation of osteoblast differentiation", "upregulation of osteoblast differentiation"], "types": ["T043"], "canonical_name": "positive regulation of osteoblast differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]"}
{"concept_id": "C1159978", "aliases": ["osteoclast cell differentiation"], "types": ["T043"], "canonical_name": "osteoclast differentiation", "definition": "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]"}
{"concept_id": "C1159979", "aliases": [], "types": ["T043"], "canonical_name": "regulation of osteoclast differentiation", "definition": "Any process that modulates the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]"}
{"concept_id": "C1159980", "aliases": ["downregulation of osteoclast differentiation", "down regulation of osteoclast differentiation", "down-regulation of osteoclast differentiation"], "types": ["T043"], "canonical_name": "negative regulation of osteoclast differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]"}
{"concept_id": "C1159981", "aliases": ["upregulation of osteoclast differentiation", "up-regulation of osteoclast differentiation", "up regulation of osteoclast differentiation"], "types": ["T043"], "canonical_name": "positive regulation of osteoclast differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]"}
{"concept_id": "C1159982", "aliases": ["photoreceptor morphogenesis"], "types": ["T043"], "canonical_name": "photoreceptor cell development", "definition": "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. [GOC:go_curators]"}
{"concept_id": "C1159983", "aliases": [], "types": ["T043"], "canonical_name": "eye photoreceptor cell development", "definition": "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. [GOC:jl, ISBN:0192800981]"}
{"concept_id": "C1159986", "aliases": [], "types": ["T042"], "canonical_name": "R1/R6 cell fate commitment", "definition": "The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres. [PMID:3076112, PMID:3937883]"}
{"concept_id": "C1159987", "aliases": [], "types": ["T042"], "canonical_name": "R2/R5 cell fate commitment", "definition": "The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres. [PMID:3076112, PMID:3937883]"}
{"concept_id": "C1159988", "aliases": [], "types": ["T042"], "canonical_name": "R3/R4 cell fate commitment", "definition": "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres. [PMID:3076112, PMID:3937883]"}
{"concept_id": "C1159989", "aliases": [], "types": ["T042"], "canonical_name": "R7 cell fate commitment", "definition": "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium. [PMID:3076112, PMID:3937883]"}
{"concept_id": "C1159990", "aliases": ["restriction of R8 fate"], "types": ["T042"], "canonical_name": "R8 cell fate commitment", "definition": "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium. [PMID:3076112, PMID:3937883]"}
{"concept_id": "C1159991", "aliases": [], "types": ["T043"], "canonical_name": "R8 cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [PMID:11880339]"}
{"concept_id": "C1159997", "aliases": ["down regulation of R7 differentiation", "down-regulation of R7 differentiation", "negative regulation of R7 differentiation", "downregulation of R7 differentiation"], "types": ["T043"], "canonical_name": "negative regulation of R7 cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1159998", "aliases": ["positive regulation of R7 differentiation", "upregulation of R7 differentiation", "up regulation of R7 differentiation", "up-regulation of R7 differentiation"], "types": ["T043"], "canonical_name": "positive regulation of R7 cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160001", "aliases": ["downregulation of R8 differentiation", "down regulation of R8 differentiation", "negative regulation of R8 differentiation", "down-regulation of R8 differentiation"], "types": ["T043"], "canonical_name": "negative regulation of R8 cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160002", "aliases": ["upregulation of R8 differentiation", "up-regulation of R8 differentiation", "positive regulation of R8 differentiation", "up regulation of R8 differentiation"], "types": ["T043"], "canonical_name": "positive regulation of R8 cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of R8 cell differentiation. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160011", "aliases": ["regulation of R8 spacing"], "types": ["T043"], "canonical_name": "regulation of R8 cell spacing in compound eye", "definition": "Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc. [GOC:dph, GOC:tb, PMID:11880339]"}
{"concept_id": "C1160013", "aliases": ["positive regulation of R8 spacing", "up regulation of R8 spacing", "upregulation of R8 spacing", "up-regulation of R8 spacing"], "types": ["T040"], "canonical_name": "positive regulation of R8 cell spacing in compound eye", "definition": "Any process that activates or enforces the correct R8 cell spacing in a compound eye. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160014", "aliases": ["R8-mediated photoreceptor organisation"], "types": ["T043"], "canonical_name": "R8 cell-mediated photoreceptor organization", "definition": "The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor. [PMID:11880339]"}
{"concept_id": "C1160018", "aliases": ["rhabdomere organization"], "types": ["T043"], "canonical_name": "rhabdomere development", "definition": "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments. [PMID:3076112, PMID:3937883]"}
{"concept_id": "C1160019", "aliases": [], "types": ["T043"], "canonical_name": "rhabdomere membrane biogenesis", "definition": "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane. [GOC:jl]"}
{"concept_id": "C1160020", "aliases": [], "types": ["T043"], "canonical_name": "photoreceptor cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. [GOC:mtg_sensu]"}
{"concept_id": "C1160021", "aliases": [], "types": ["T043"], "canonical_name": "photoreceptor cell differentiation", "definition": "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1160023", "aliases": ["regulation of photoreceptor differentiation"], "types": ["T043"], "canonical_name": "regulation of photoreceptor cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. [GOC:go_curators]"}
{"concept_id": "C1160024", "aliases": ["down-regulation of photoreceptor differentiation", "inhibition of photoreceptor differentiation", "downregulation of photoreceptor differentiation", "downregulation of photoreceptor cell differentiation", "down regulation of photoreceptor cell differentiation", "negative regulation of photoreceptor differentiation", "down regulation of photoreceptor differentiation", "down-regulation of photoreceptor cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of photoreceptor cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. [GOC:go_curators]"}
{"concept_id": "C1160025", "aliases": ["upregulation of photoreceptor cell differentiation", "stimulation of photoreceptor differentiation", "activation of photoreceptor differentiation", "positive regulation of photoreceptor differentiation", "upregulation of photoreceptor differentiation", "up-regulation of photoreceptor differentiation", "up regulation of photoreceptor differentiation", "up-regulation of photoreceptor cell differentiation", "up regulation of photoreceptor cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of photoreceptor cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. [GOC:go_curators]"}
{"concept_id": "C1160026", "aliases": ["regulation of eye photoreceptor development"], "types": ["T043"], "canonical_name": "regulation of eye photoreceptor cell development", "definition": "Any process that modulates the frequency, rate or extent of eye photoreceptor development. [GOC:jl]"}
{"concept_id": "C1160027", "aliases": ["down-regulation of eye photoreceptor cell development", "negative regulation of eye photoreceptor development", "down regulation of eye photoreceptor cell development", "inhibition of eye photoreceptor development", "downregulation of eye photoreceptor development", "down-regulation of eye photoreceptor development", "down regulation of eye photoreceptor development", "downregulation of eye photoreceptor cell development"], "types": ["T043"], "canonical_name": "negative regulation of eye photoreceptor cell development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. [GOC:jl]"}
{"concept_id": "C1160028", "aliases": ["positive regulation of eye photoreceptor development", "up regulation of eye photoreceptor cell development", "up-regulation of eye photoreceptor development", "stimulation of eye photoreceptor development", "up-regulation of eye photoreceptor cell development", "up regulation of eye photoreceptor development", "activation of eye photoreceptor development", "upregulation of eye photoreceptor development", "upregulation of eye photoreceptor cell development"], "types": ["T043"], "canonical_name": "positive regulation of eye photoreceptor cell development", "definition": "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. [GOC:jl]"}
{"concept_id": "C1160029", "aliases": [], "types": ["T043"], "canonical_name": "retinal cone cell development", "definition": "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. [ISBN:0198506732]"}
{"concept_id": "C1160030", "aliases": [], "types": ["T043"], "canonical_name": "retinal cone cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye. [GOC:mtg_sensu, PMID:3076112, PMID:3937883]"}
{"concept_id": "C1160031", "aliases": [], "types": ["T043"], "canonical_name": "retinal rod cell development", "definition": "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. [ISBN:0198506732]"}
{"concept_id": "C1160033", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. [GOC:go_curators]"}
{"concept_id": "C1160036", "aliases": [], "types": ["T043"], "canonical_name": "cell fate commitment", "definition": "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. [ISBN:0716731185]"}
{"concept_id": "C1160037", "aliases": [], "types": ["T043"], "canonical_name": "cell fate determination", "definition": "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. [ISBN:0878932437]"}
{"concept_id": "C1160038", "aliases": ["ectoderm cell fate determination"], "types": ["T042"], "canonical_name": "ectodermal cell fate determination", "definition": "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators, ISBN:0878932437]"}
{"concept_id": "C1160039", "aliases": ["endoderm cell fate determination"], "types": ["T042"], "canonical_name": "endodermal cell fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators, ISBN:0878932437]"}
{"concept_id": "C1160041", "aliases": ["mesoderm cell fate determination"], "types": ["T042"], "canonical_name": "mesodermal cell fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators, ISBN:0878932437]"}
{"concept_id": "C1160042", "aliases": [], "types": ["T043"], "canonical_name": "cell fate specification", "definition": "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. [GOC:go_curators]"}
{"concept_id": "C1160043", "aliases": ["ectoderm cell fate specification"], "types": ["T042"], "canonical_name": "ectodermal cell fate specification", "definition": "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:go_curators]"}
{"concept_id": "C1160044", "aliases": ["endoderm cell fate specification"], "types": ["T042"], "canonical_name": "endodermal cell fate specification", "definition": "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:go_curators]"}
{"concept_id": "C1160045", "aliases": ["mesoderm cell fate specification"], "types": ["T042"], "canonical_name": "mesodermal cell fate specification", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:go_curators]"}
{"concept_id": "C1160047", "aliases": ["ectoderm cell fate commitment"], "types": ["T042"], "canonical_name": "ectodermal cell fate commitment", "definition": "The cell differentiation process that results in commitment of a cell to become part of the ectoderm. [GOC:go_curators, ISBN:0878932437]"}
{"concept_id": "C1160048", "aliases": ["endoderm cell fate commitment"], "types": ["T042"], "canonical_name": "endodermal cell fate commitment", "definition": "The cell differentiation process that results in commitment of a cell to become part of the endoderm. [GOC:go_curators, ISBN:0878932437]"}
{"concept_id": "C1160049", "aliases": ["mesoderm cell fate commitment"], "types": ["T042"], "canonical_name": "mesodermal cell fate commitment", "definition": "The cell differentiation process that results in commitment of a cell to become part of the mesoderm. [GOC:go_curators, ISBN:0878932437]"}
{"concept_id": "C1160050", "aliases": [], "types": ["T043"], "canonical_name": "cellularization", "definition": "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development. [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]"}
{"concept_id": "C1160054", "aliases": [], "types": ["T040"], "canonical_name": "embryonic development via the syncytial blastoderm", "definition": "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1160055", "aliases": [], "types": ["T040"], "canonical_name": "amnioserosa maintenance", "definition": "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. [GOC:bf]"}
{"concept_id": "C1160056", "aliases": [], "types": ["T040"], "canonical_name": "dorsal closure", "definition": "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally. [PMID:9224720]"}
{"concept_id": "C1160057", "aliases": [], "types": ["T042"], "canonical_name": "dorsal closure, amnioserosa morphology change", "definition": "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo. [PMID:12147138]"}
{"concept_id": "C1160058", "aliases": [], "types": ["T040"], "canonical_name": "initiation of dorsal closure", "definition": "Events that occur at the start of dorsal closure. [GOC:bf]"}
{"concept_id": "C1160060", "aliases": [], "types": ["T040"], "canonical_name": "suture of dorsal opening", "definition": "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole. [GOC:bf, PMID:12147138]"}
{"concept_id": "C1160062", "aliases": ["germ-band retraction"], "types": ["T040"], "canonical_name": "germ-band shortening", "definition": "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo. [GOC:bf, PMID:12147138]"}
{"concept_id": "C1160063", "aliases": [], "types": ["T042"], "canonical_name": "head involution", "definition": "Movement of the anterior ectoderm to the interior of the embryo. [ISBN:0879694238]"}
{"concept_id": "C1160064", "aliases": [], "types": ["T042"], "canonical_name": "oenocyte development", "definition": "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments. [GOC:bf, PMID:11171397]"}
{"concept_id": "C1160065", "aliases": [], "types": ["T040"], "canonical_name": "pseudocleavage during syncytial blastoderm formation"}
{"concept_id": "C1160066", "aliases": [], "types": ["T040"], "canonical_name": "in utero embryonic development", "definition": "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1160067", "aliases": [], "types": ["T042"], "canonical_name": "formation of primary germ layer", "definition": "The formation of the ectoderm, mesoderm and endoderm during gastrulation. [GOC:go_curators]"}
{"concept_id": "C1160068", "aliases": [], "types": ["T042"], "canonical_name": "ectoderm formation", "definition": "The formation of ectoderm during gastrulation. [GOC:go_curators]"}
{"concept_id": "C1160069", "aliases": [], "types": ["T042"], "canonical_name": "endoderm formation", "definition": "The formation of the endoderm during gastrulation. [GOC:go_curators]"}
{"concept_id": "C1160070", "aliases": [], "types": ["T042"], "canonical_name": "mesoderm formation", "definition": "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:go_curators]"}
{"concept_id": "C1160073", "aliases": [], "types": ["T040"], "canonical_name": "gastrulation with mouth forming first", "definition": "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1160074", "aliases": [], "types": ["T042"], "canonical_name": "amnioserosa formation", "definition": "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift. [ISBN:0879694238]"}
{"concept_id": "C1160075", "aliases": [], "types": ["T040"], "canonical_name": "anterior midgut invagination", "definition": "Internalization of the anterior midgut into the interior of the embryo. [ISBN:0879694238]"}
{"concept_id": "C1160076", "aliases": [], "types": ["T042"], "canonical_name": "cephalic furrow formation", "definition": "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome. [ISBN:0879694238]"}
{"concept_id": "C1160077", "aliases": [], "types": ["T042"], "canonical_name": "germ-band extension", "definition": "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further. [ISBN:0879694238]"}
{"concept_id": "C1160078", "aliases": [], "types": ["T040"], "canonical_name": "posterior midgut invagination", "definition": "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior. [ISBN:0879694238]"}
{"concept_id": "C1160079", "aliases": [], "types": ["T040"], "canonical_name": "ventral furrow formation", "definition": "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation. [ISBN:0879694238]"}
{"concept_id": "C1160080", "aliases": [], "types": ["T040"], "canonical_name": "ventral midline determination", "definition": "The regionalization process in which the area where the ventral midline will form is specified. [GOC:bf, GOC:isa_complete, GOC:vk]"}
{"concept_id": "C1160081", "aliases": [], "types": ["T042"], "canonical_name": "determination of anterior border of ventral midline"}
{"concept_id": "C1160082", "aliases": [], "types": ["T042"], "canonical_name": "determination of posterior border of ventral midline"}
{"concept_id": "C1160083", "aliases": ["neural tube morphogenesis", "neurulation"], "types": ["T040"], "definition": "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. [GOC:dph, ISBN:0878932437]", "canonical_name": "neural tube formation"}
{"concept_id": "C1160084", "aliases": [], "types": ["T040"], "canonical_name": "pseudocleavage", "definition": "Partial constriction of the cytoplasm of a cell to form a furrow that resembles a cleavage furrow but does not complete cytokinesis. [GOC:mah, PMID:10751167, PMID:30990821, PMID:7729583]"}
{"concept_id": "C1160085", "aliases": [], "types": ["T040"], "canonical_name": "first cell cycle pseudocleavage", "definition": "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms. [GOC:mtg_sensu, PMID:7729583]"}
{"concept_id": "C1160086", "aliases": [], "types": ["T042"], "canonical_name": "embryo development ending in seed dormancy", "definition": "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1160087", "aliases": ["embryonic anatomical structure morphogenesis"], "types": ["T040"], "canonical_name": "embryonic morphogenesis", "definition": "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1160089", "aliases": [], "types": ["T040"], "canonical_name": "female analia morphogenesis", "definition": "The process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11494318]"}
{"concept_id": "C1160090", "aliases": [], "types": ["T042"], "canonical_name": "male analia morphogenesis", "definition": "The process in which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. [GOC:mtg_sensu, PMID:11494318]"}
{"concept_id": "C1160091", "aliases": [], "types": ["T042"], "canonical_name": "antennal morphogenesis", "definition": "The process in which the anatomical structures of the antenna are generated and organized. [GOC:jid]"}
{"concept_id": "C1160093", "aliases": [], "types": ["T042"], "canonical_name": "bristle morphogenesis"}
{"concept_id": "C1160094", "aliases": ["hearing organ morphogenesis"], "types": ["T042"], "canonical_name": "ear morphogenesis", "definition": "The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1160095", "aliases": [], "types": ["T042"], "canonical_name": "inner ear morphogenesis", "definition": "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1160096", "aliases": [], "types": ["T042"], "canonical_name": "middle ear morphogenesis", "definition": "The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1160097", "aliases": [], "types": ["T042"], "canonical_name": "outer ear morphogenesis", "definition": "The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1160098", "aliases": ["genital morphogenesis"], "types": ["T042"], "canonical_name": "genitalia morphogenesis", "definition": "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. [GOC:bf]"}
{"concept_id": "C1160099", "aliases": ["female genital morphogenesis"], "types": ["T042"], "canonical_name": "female genitalia morphogenesis", "definition": "The process in which the anatomical structures of female genitalia are generated and organized. [GOC:mah]"}
{"concept_id": "C1160100", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc-derived female genitalia morphogenesis", "definition": "The process in which the anatomical structures of female genitalia are generated and organized from the genital disc. [GOC:ai, GOC:sensu]"}
{"concept_id": "C1160105", "aliases": ["ectodermal gut morphogenesis"], "types": ["T042"], "canonical_name": "ectodermal digestive tract morphogenesis", "definition": "The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm. [GOC:jid]"}
{"concept_id": "C1160106", "aliases": [], "types": ["T042"], "canonical_name": "anterior midgut (ectodermal) morphogenesis", "definition": "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1160107", "aliases": [], "types": ["T042"], "canonical_name": "foregut morphogenesis", "definition": "The process in which the anatomical structures of the foregut are generated and organized. [GOC:jid]"}
{"concept_id": "C1160108", "aliases": [], "types": ["T042"], "canonical_name": "hindgut morphogenesis", "definition": "The process in which the anatomical structures of the hindgut are generated and organized. [GOC:jid]"}
{"concept_id": "C1160109", "aliases": [], "types": ["T042"], "canonical_name": "Malpighian tubule morphogenesis", "definition": "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut. [GOC:bf, ISBN:0582227089]"}
{"concept_id": "C1160110", "aliases": [], "types": ["T042"], "canonical_name": "haltere morphogenesis", "definition": "The process in which the anatomical structures of a haltere are generated and organized. [GOC:jid, GOC:rc]"}
{"concept_id": "C1160111", "aliases": ["imaginal disc metamorphosis"], "types": ["T042"], "canonical_name": "imaginal disc morphogenesis", "definition": "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. [GOC:jid]"}
{"concept_id": "C1160112", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc eversion", "definition": "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis. [PMID:11494317]"}
{"concept_id": "C1160113", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc fusion", "definition": "The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis. [PMID:11494317]"}
{"concept_id": "C1160114", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc fusion, thorax closure", "definition": "The joining of the parts of the wing imaginal discs, giving rise to the adult thorax. [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]"}
{"concept_id": "C1160115", "aliases": [], "types": ["T042"], "canonical_name": "morphogenesis of larval imaginal disc epithelium", "definition": "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized. [GOC:jl]"}
{"concept_id": "C1160116", "aliases": [], "types": ["T042"], "canonical_name": "establishment or maintenance of polarity of larval imaginal disc epithelium", "definition": "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium. [GOC:jl, GOC:mah]"}
{"concept_id": "C1160118", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of polarity of larval imaginal disc epithelium", "definition": "The maintenance of an established polarized larval imaginal disc epithelium. [GOC:jl]"}
{"concept_id": "C1160119", "aliases": [], "types": ["T040"], "canonical_name": "limb morphogenesis", "definition": "The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping. [UBERON:0002101]"}
{"concept_id": "C1160121", "aliases": [], "types": ["T040"], "canonical_name": "leg joint morphogenesis", "definition": "OBSOLETE. The process in which the anatomical structures of a leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. One example is the knee, which separates the leg tibia and femur. [GOC:bf, ISBN:0582227089, PMID:12051824]"}
{"concept_id": "C1160122", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc-derived leg joint morphogenesis", "definition": "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1160123", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc-derived leg morphogenesis", "definition": "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1160124", "aliases": [], "types": ["T042"], "canonical_name": "morphogenesis of embryonic epithelium", "definition": "The process in which the anatomical structures of embryonic epithelia are generated and organized. [GOC:jl]"}
{"concept_id": "C1160125", "aliases": [], "types": ["T042"], "canonical_name": "establishment or maintenance of polarity of embryonic epithelium", "definition": "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo. [GOC:isa_complete, GOC:mah]"}
{"concept_id": "C1160127", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of polarity of embryonic epithelium", "definition": "The maintenance of an established polarized embryonic epithelial sheet. [GOC:jl]"}
{"concept_id": "C1160132", "aliases": [], "types": ["T042"], "canonical_name": "sternite morphogenesis", "definition": "The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment. [GOC:jid, http://www.earthlife.net]"}
{"concept_id": "C1160133", "aliases": ["male tail tip morphogenesis", "male tail morphogenesis"], "types": ["T040"], "canonical_name": "tail tip morphogenesis"}
{"concept_id": "C1160134", "aliases": [], "types": ["T042"], "canonical_name": "tergite morphogenesis", "definition": "The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment. [GOC:jid, http://www.earthlife.net]"}
{"concept_id": "C1160135", "aliases": ["wing morphogenesis"], "types": ["T042"], "canonical_name": "imaginal disc-derived wing morphogenesis", "definition": "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1160136", "aliases": ["wing margin morphogenesis"], "types": ["T042"], "canonical_name": "imaginal disc-derived wing margin morphogenesis", "definition": "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade. [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1160137", "aliases": ["apposition of dorsal and ventral wing surfaces"], "types": ["T042"], "canonical_name": "apposition of dorsal and ventral imaginal disc-derived wing surfaces", "definition": "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1160138", "aliases": ["wing vein morphogenesis"], "types": ["T042"], "canonical_name": "imaginal disc-derived wing vein morphogenesis", "definition": "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized. [GOC:mtg_sensu]"}
{"concept_id": "C1160139", "aliases": ["wing vein specification"], "types": ["T042"], "canonical_name": "imaginal disc-derived wing vein specification", "definition": "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified. [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]"}
{"concept_id": "C1160140", "aliases": ["embryonic pattern formation"], "types": ["T040"], "definition": "The process that results in the patterns of cell differentiation that will arise in an embryo. [GOC:go_curators, ISBN:0521436125]", "canonical_name": "embryonic pattern specification"}
{"concept_id": "C1160141", "aliases": ["embryonic axis determination"], "types": ["T040"], "canonical_name": "embryonic axis specification", "definition": "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C1160142", "aliases": [], "types": ["T040"], "canonical_name": "anterior/posterior axis determination, embryo"}
{"concept_id": "C1160143", "aliases": [], "types": ["T040"], "canonical_name": "maternal determination of anterior/posterior axis, embryo", "definition": "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160144", "aliases": [], "types": ["T043"], "canonical_name": "zygotic determination of anterior/posterior axis, embryo", "definition": "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160145", "aliases": [], "types": ["T040"], "canonical_name": "anterior region determination", "definition": "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160146", "aliases": [], "types": ["T040"], "canonical_name": "posterior abdomen determination", "definition": "The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes. [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160149", "aliases": [], "types": ["T040"], "canonical_name": "terminal region determination", "definition": "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160152", "aliases": [], "types": ["T040"], "canonical_name": "thorax and anterior abdomen determination", "definition": "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160155", "aliases": ["zygotic determination of dorsal-ventral axis", "zygotic determination of dorsoventral axis"], "types": ["T043"], "canonical_name": "zygotic determination of dorsal/ventral axis"}
{"concept_id": "C1160156", "aliases": ["patterning of blood vessels"], "types": ["T040"], "canonical_name": "branching involved in blood vessel morphogenesis", "definition": "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. [GOC:dph]"}
{"concept_id": "C1160157", "aliases": [], "types": ["T040"], "canonical_name": "segment specification", "definition": "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160158", "aliases": [], "types": ["T040"], "canonical_name": "blastoderm segmentation", "definition": "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160159", "aliases": [], "types": ["T040"], "canonical_name": "periodic partitioning", "definition": "The regionalization process that divides the spatial regions of an embryo into serially repeated regions. [GOC:dph, GOC:isa_complete, GOC:ma]"}
{"concept_id": "C1160160", "aliases": [], "types": ["T040"], "canonical_name": "periodic partitioning by pair rule gene", "definition": "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]"}
{"concept_id": "C1160161", "aliases": [], "types": ["T042"], "canonical_name": "segment polarity determination", "definition": "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]"}
{"concept_id": "C1160163", "aliases": [], "types": ["T040"], "canonical_name": "ventral/lateral system", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1160164", "aliases": [], "types": ["T040"], "canonical_name": "specification of segmental identity, abdomen", "definition": "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [ISBN:0878932437]"}
{"concept_id": "C1160165", "aliases": [], "types": ["T040"], "canonical_name": "specification of segmental identity, antennal segment", "definition": "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [ISBN:0878932437]"}
{"concept_id": "C1160166", "aliases": [], "types": ["T040"], "canonical_name": "specification of segmental identity, head", "definition": "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [ISBN:0878932437]"}
{"concept_id": "C1160167", "aliases": [], "types": ["T040"], "canonical_name": "specification of segmental identity, labial segment", "definition": "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [ISBN:0878932437]"}
{"concept_id": "C1160168", "aliases": [], "types": ["T040"], "canonical_name": "specification of segmental identity, mandibular segment", "definition": "The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [ISBN:0878932437]"}
{"concept_id": "C1160169", "aliases": [], "types": ["T040"], "canonical_name": "specification of segmental identity, maxillary segment", "definition": "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [ISBN:0878932437]"}
{"concept_id": "C1160170", "aliases": [], "types": ["T040"], "canonical_name": "specification of segmental identity, thorax", "definition": "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [ISBN:0878932437]"}
{"concept_id": "C1160171", "aliases": [], "types": ["T040"], "canonical_name": "regulation of embryonic development", "definition": "Any process that modulates the frequency, rate or extent of embryonic development. [GOC:go_curators]"}
{"concept_id": "C1160172", "aliases": ["down-regulation of embryonic development", "downregulation of embryonic development", "down regulation of embryonic development"], "types": ["T040"], "canonical_name": "negative regulation of embryonic development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. [GOC:go_curators]"}
{"concept_id": "C1160173", "aliases": ["up-regulation of embryonic development", "up regulation of embryonic development", "upregulation of embryonic development"], "types": ["T040"], "canonical_name": "positive regulation of embryonic development", "definition": "Any process that activates or increases the frequency, rate or extent of embryonic development. [GOC:go_curators]"}
{"concept_id": "C1160174", "aliases": [], "types": ["T042"], "canonical_name": "regulation of flower development", "definition": "Any process that modulates the frequency, rate or extent of flower development. [GOC:go_curators]"}
{"concept_id": "C1160175", "aliases": ["downregulation of flower development", "down regulation of flower development", "down-regulation of flower development"], "types": ["T042"], "canonical_name": "negative regulation of flower development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of flower development. [GOC:go_curators]"}
{"concept_id": "C1160176", "aliases": ["up-regulation of flower development", "upregulation of flower development", "up regulation of flower development"], "types": ["T042"], "canonical_name": "positive regulation of flower development", "definition": "Any process that activates or increases the frequency, rate or extent of flower development. [GOC:go_curators]"}
{"concept_id": "C1160177", "aliases": ["fruiting body formation", "fruiting body development"], "types": ["T040"], "canonical_name": "reproductive fruiting body development", "definition": "The process whose specific outcome is the progression of a reproductive fruiting body over time, from its formation to the mature structure. A reproductive fruiting body is a multicellular reproductive structure that contains spores. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1160178", "aliases": [], "types": ["T040"], "canonical_name": "sporocarp development", "definition": "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1160180", "aliases": ["DNA mediated transformation"], "types": ["T040"], "canonical_name": "DNA-mediated transformation", "definition": "The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope. [PMID:12706993, PMID:24509783, PMID:27826682]"}
{"concept_id": "C1160181", "aliases": [], "types": ["T043"], "canonical_name": "establishment of competence for transformation", "definition": "The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation. [GOC:mah, ISBN:1555811027]"}
{"concept_id": "C1160182", "aliases": [], "types": ["T040"], "canonical_name": "regulation of establishment of competence for transformation", "definition": "Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome. [GOC:mlg]"}
{"concept_id": "C1160183", "aliases": ["down regulation of establishment of competence for transformation", "downregulation of establishment of competence for transformation", "down-regulation of establishment of competence for transformation"], "types": ["T040"], "canonical_name": "negative regulation of establishment of competence for transformation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of competence for transformation. [GOC:go_curators]"}
{"concept_id": "C1160184", "aliases": ["up-regulation of establishment of competence for transformation", "up regulation of establishment of competence for transformation", "upregulation of establishment of competence for transformation"], "types": ["T040"], "canonical_name": "positive regulation of establishment of competence for transformation", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation. [GOC:go_curators]"}
{"concept_id": "C1160185", "aliases": [], "types": ["T040"], "definition": "A type of horizontal gene transfer in which genetic material is introduced into a cell mediated by a virus. [PMID:18265289, PMID:33597173]", "canonical_name": "transduction"}
{"concept_id": "C1160186", "aliases": [], "types": ["T043"], "definition": "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells. Some or all of the chromosome(s) of the donor cell is transferred into the recipient cell. [Wikipedia:Bacterial_conjugation]", "canonical_name": "unidirectional conjugation"}
{"concept_id": "C1160187", "aliases": [], "types": ["T043"], "canonical_name": "pheromone-induced unidirectional conjugation", "definition": "Unidirectional transfer of genetic information triggered by to a pheromone signal. [GOC:elh, PMID:17360276, PMID:27021562, PMID:31191478]"}
{"concept_id": "C1160188", "aliases": [], "types": ["T043"], "canonical_name": "pollen germination", "definition": "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture. [GOC:lr, http://www.bio.uu.nl, ISBN:0943088399]"}
{"concept_id": "C1160189", "aliases": [], "types": ["T040"], "canonical_name": "seed germination", "definition": "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis. [PMID:8281041]"}
{"concept_id": "C1160190", "aliases": [], "types": ["T039"], "canonical_name": "spore germination", "definition": "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall). [GOC:lr]"}
{"concept_id": "C1160191", "aliases": [], "types": ["T040"], "definition": "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. [GOC:ems, GOC:mah]", "canonical_name": "regulation of growth"}
{"concept_id": "C1160192", "aliases": ["down regulation of growth", "down-regulation of growth", "downregulation of growth"], "types": ["T040"], "canonical_name": "negative regulation of growth", "definition": "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. [GOC:go_curators]"}
{"concept_id": "C1160193", "aliases": ["negative regulation of body growth", "negative regulation of body size"], "types": ["T040"], "canonical_name": "negative regulation of multicellular organism growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. [GOC:dph, GOC:ems, GOC:tb]"}
{"concept_id": "C1160194", "aliases": ["down-regulation of development, heterochronic", "downregulation of development, heterochronic", "down regulation of development, heterochronic"], "types": ["T040"], "canonical_name": "negative regulation of development, heterochronic", "definition": "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and decreases the rate at which this time point is reached. [GOC:go_curators]"}
{"concept_id": "C1160195", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of organ growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. [GOC:bf, GOC:tb]"}
{"concept_id": "C1160196", "aliases": ["up regulation of growth", "up-regulation of growth", "upregulation of growth"], "types": ["T040"], "canonical_name": "positive regulation of growth", "definition": "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. [GOC:go_curators]"}
{"concept_id": "C1160197", "aliases": ["positive regulation of body size", "positive regulation of body growth"], "types": ["T040"], "canonical_name": "positive regulation of multicellular organism growth", "definition": "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160198", "aliases": ["up-regulation of development, heterochronic", "up regulation of development, heterochronic", "upregulation of development, heterochronic"], "types": ["T040"], "canonical_name": "positive regulation of development, heterochronic", "definition": "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and increases the rate at which this time point is reached. [GOC:go_curators]"}
{"concept_id": "C1160199", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of organ growth", "definition": "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. [GOC:bf, GOC:tb]"}
{"concept_id": "C1160201", "aliases": ["heterochronic regulation of development", "temporal regulation of development"], "types": ["T040"], "canonical_name": "regulation of development, heterochronic", "definition": "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. [PMID:9442909]"}
{"concept_id": "C1160202", "aliases": [], "types": ["T040"], "canonical_name": "regulation of organ growth", "definition": "Any process that modulates the frequency, rate or extent of growth of an organ of an organism. [GOC:bf, GOC:tb]"}
{"concept_id": "C1160205", "aliases": [], "types": ["T043"], "canonical_name": "sperm competition", "definition": "Any process that contributes to the success of sperm fertilization in multiply-mated females. [PMID:10885514]"}
{"concept_id": "C1160206", "aliases": [], "types": ["T042"], "canonical_name": "sperm displacement", "definition": "The physical displacement of sperm stored from previous mating encounters. [PMID:10440373]"}
{"concept_id": "C1160207", "aliases": [], "types": ["T043"], "canonical_name": "sperm incapacitation", "definition": "The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males. [PMID:10440373]"}
{"concept_id": "C1160208", "aliases": ["sperm retention", "sperm sequestration", "sequestration of sperm", "sperm sequestering", "sperm storage", "storage of sperm", "retention of sperm"], "types": ["T042"], "definition": "The retention of sperm by a female following mating. [PMID:10885514]", "canonical_name": "sequestering of sperm"}
{"concept_id": "C1160209", "aliases": [], "types": ["T040"], "canonical_name": "larval development", "definition": "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. [GOC:jid, ISBN:0877795088]"}
{"concept_id": "C1160210", "aliases": [], "types": ["T040"], "canonical_name": "amphibian larval development", "definition": "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form. [GOC:bf, PMID:27143402]"}
{"concept_id": "C1160212", "aliases": [], "types": ["T040"], "canonical_name": "nematode larval development", "definition": "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. [GOC:ems, GOC:kmv]"}
{"concept_id": "C1160214", "aliases": [], "types": ["T040"], "canonical_name": "vulval development", "definition": "The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. [GOC:ems, GOC:kmv, ISBN:087969307X]"}
{"concept_id": "C1160215", "aliases": [], "types": ["T040"], "canonical_name": "regulation of vulval development", "definition": "Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. [GOC:kmv, GOC:ma]"}
{"concept_id": "C1160216", "aliases": ["down-regulation of vulval development", "down regulation of vulval development", "downregulation of vulval development"], "types": ["T040"], "canonical_name": "negative regulation of vulval development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. [GOC:ems, GOC:kmv]"}
{"concept_id": "C1160217", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of vulval development", "definition": "Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. [GOC:ems, GOC:kmv]"}
{"concept_id": "C1160218", "aliases": [], "types": ["T042"], "canonical_name": "larval heart development", "definition": "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160221", "aliases": [], "types": ["T042"], "canonical_name": "larval somatic muscle development", "definition": "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1160222", "aliases": [], "types": ["T042"], "canonical_name": "larval visceral muscle development", "definition": "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1160223", "aliases": [], "types": ["T040"], "canonical_name": "instar larval or pupal development", "definition": "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1160224", "aliases": [], "types": ["T040"], "canonical_name": "instar larval development", "definition": "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1160225", "aliases": [], "types": ["T042"], "canonical_name": "larval fat body development", "definition": "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160226", "aliases": ["larval salivary gland determination"], "types": ["T042"], "canonical_name": "larval salivary gland determination"}
{"concept_id": "C1160227", "aliases": ["regulation of larval salivary gland determination"], "types": ["T040"], "canonical_name": "regulation of larval salivary gland boundary specification", "definition": "Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160228", "aliases": ["down-regulation of larval salivary gland determination", "downregulation of larval salivary gland determination", "negative regulation of larval salivary gland determination", "down regulation of larval salivary gland determination"], "types": ["T040"], "canonical_name": "negative regulation of larval salivary gland boundary specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in a larval organism. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160229", "aliases": ["up regulation of larval salivary gland determination", "up-regulation of larval salivary gland determination", "positive regulation of larval salivary gland determination", "upregulation of larval salivary gland determination"], "types": ["T040"], "canonical_name": "positive regulation of larval salivary gland boundary specification", "definition": "Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160230", "aliases": [], "types": ["T042"], "canonical_name": "larval salivary gland morphogenesis", "definition": "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized. [GOC:jid]"}
{"concept_id": "C1160232", "aliases": [], "types": ["T040"], "canonical_name": "eclosion", "definition": "The emergence of an adult insect from a pupa case. [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461]"}
{"concept_id": "C1160234", "aliases": [], "types": ["T042"], "canonical_name": "cuticle hardening"}
{"concept_id": "C1160238", "aliases": [], "types": ["T040"], "canonical_name": "regulation of eclosion", "definition": "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg. [GOC:go_curators, ISBN:0198600461]"}
{"concept_id": "C1160239", "aliases": ["down regulation of eclosion", "downregulation of eclosion", "down-regulation of eclosion"], "types": ["T040"], "canonical_name": "negative regulation of eclosion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion. [GOC:go_curators]"}
{"concept_id": "C1160240", "aliases": ["up-regulation of eclosion", "up regulation of eclosion", "upregulation of eclosion"], "types": ["T040"], "canonical_name": "positive regulation of eclosion", "definition": "Any process that activates or increases the frequency, rate or extent of eclosion. [GOC:go_curators]"}
{"concept_id": "C1160241", "aliases": ["meristem organization", "meristem organisation"], "types": ["T042"], "canonical_name": "meristem structural organization", "definition": "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue. [GOC:sm, ISBN:0198547684]"}
{"concept_id": "C1160242", "aliases": ["regulation of meristem organisation", "regulation of meristem organization"], "types": ["T042"], "canonical_name": "regulation of meristem structural organization", "definition": "Any process that modulates the frequency, rate or extent of meristem organization. [GOC:jid]"}
{"concept_id": "C1160243", "aliases": ["epithelium morphogenesis"], "types": ["T042"], "canonical_name": "morphogenesis of an epithelium", "definition": "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]"}
{"concept_id": "C1160244", "aliases": [], "types": ["T042"], "canonical_name": "morphogenesis of an epithelial sheet", "definition": "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. [GOC:jl]"}
{"concept_id": "C1160245", "aliases": [], "types": ["T042"], "canonical_name": "morphogenesis of follicular epithelium", "definition": "The process in which the anatomical structures of a follicular epithelium are generated and organized. [GOC:jl]"}
{"concept_id": "C1160246", "aliases": [], "types": ["T042"], "canonical_name": "establishment or maintenance of polarity of follicular epithelium", "definition": "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet. [GOC:bf, GOC:mah]"}
{"concept_id": "C1160248", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of polarity of follicular epithelium", "definition": "The maintenance of an established polarized follicular epithelial sheet. [GOC:bf]"}
{"concept_id": "C1160249", "aliases": [], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. [GOC:dgh]", "canonical_name": "adrenal gland development"}
{"concept_id": "C1160250", "aliases": [], "types": ["T042"], "canonical_name": "blood vessel development", "definition": "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. [GOC:hjd, UBERON:0001981]"}
{"concept_id": "C1160251", "aliases": [], "types": ["T040"], "canonical_name": "regulation of angiogenesis", "definition": "Any process that modulates the frequency, rate or extent of angiogenesis. [GOC:go_curators]"}
{"concept_id": "C1160253", "aliases": ["up regulation of angiogenesis", "up-regulation of angiogenesis", "upregulation of angiogenesis"], "types": ["T040"], "definition": "Any process that activates or increases angiogenesis. [GOC:go_curators]", "canonical_name": "positive regulation of angiogenesis"}
{"concept_id": "C1160254", "aliases": [], "types": ["T042"], "canonical_name": "eye morphogenesis", "definition": "The process in which the anatomical structures of the eye are generated and organized. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1160262", "aliases": [], "types": ["T042"], "canonical_name": "fat body development", "definition": "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism. [ISBN:0582227089]"}
{"concept_id": "C1160263", "aliases": [], "types": ["T042"], "canonical_name": "adult fat body development", "definition": "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160264", "aliases": ["gonadogenesis"], "types": ["T042"], "canonical_name": "gonad development", "definition": "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. [GOC:ems, ISBN:0198506732]"}
{"concept_id": "C1160265", "aliases": ["ovary development", "ovarian development"], "types": ["T042"], "canonical_name": "female gonad development", "definition": "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. [GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1160266", "aliases": [], "types": ["T042"], "canonical_name": "ovarian follicle atresia", "definition": "A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed. [GOC:mtg_apoptosis, PMID:18638134]"}
{"concept_id": "C1160267", "aliases": [], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]", "canonical_name": "ovarian follicle development"}
{"concept_id": "C1160268", "aliases": [], "types": ["T042"], "canonical_name": "ovarian follicle endowment", "definition": "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles. [PMID:30010832]"}
{"concept_id": "C1160269", "aliases": [], "types": ["T042"], "canonical_name": "ovarian follicle rupture", "definition": "Disruption of theca cell layer releasing follicular fluid and/or the oocyte. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]"}
{"concept_id": "C1160270", "aliases": [], "types": ["T042"], "canonical_name": "gonadal mesoderm development", "definition": "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. [GOC:ai]"}
{"concept_id": "C1160271", "aliases": ["testis development", "testicular development"], "types": ["T042"], "canonical_name": "male gonad development", "definition": "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1160272", "aliases": [], "types": ["T042"], "canonical_name": "dorsal vessel development"}
{"concept_id": "C1160273", "aliases": [], "types": ["T042"], "canonical_name": "adult heart development", "definition": "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. [GOC:bf]"}
{"concept_id": "C1160275", "aliases": [], "types": ["T042"], "canonical_name": "ectoderm development", "definition": "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. [GOC:dph, GOC:tb]"}
{"concept_id": "C1160280", "aliases": [], "types": ["T042"], "canonical_name": "endoderm development", "definition": "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. [GOC:dph, GOC:tb]"}
{"concept_id": "C1160281", "aliases": [], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. [GOC:dph, GOC:tb]", "canonical_name": "mesoderm development"}
{"concept_id": "C1160282", "aliases": ["ectoderm/mesoderm interaction"], "types": ["T042"], "canonical_name": "ectoderm and mesoderm interaction", "definition": "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm. [GOC:isa_complete]"}
{"concept_id": "C1160283", "aliases": [], "types": ["T042"], "canonical_name": "digestive tract mesoderm development", "definition": "The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism. [GOC:ai]"}
{"concept_id": "C1160284", "aliases": [], "types": ["T042"], "canonical_name": "otolith mineralization", "definition": "The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear. [GOC:dsf, PMID:15581873]"}
{"concept_id": "C1160285", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc development", "definition": "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.). [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160286", "aliases": [], "types": ["T042"], "canonical_name": "determination of imaginal disc primordium", "definition": "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment. [ISBN:0879694238]"}
{"concept_id": "C1160287", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc growth", "definition": "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. [GOC:bf, GOC:jid, PMID:10679387]"}
{"concept_id": "C1160288", "aliases": [], "types": ["T040"], "canonical_name": "regulation of imaginal disc growth", "definition": "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc. [GOC:go_curators]"}
{"concept_id": "C1160289", "aliases": ["downregulation of imaginal disc growth", "down-regulation of imaginal disc growth", "down regulation of imaginal disc growth"], "types": ["T040"], "canonical_name": "negative regulation of imaginal disc growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth. [GOC:go_curators]"}
{"concept_id": "C1160290", "aliases": ["upregulation of imaginal disc growth", "up-regulation of imaginal disc growth", "up regulation of imaginal disc growth"], "types": ["T040"], "canonical_name": "positive regulation of imaginal disc growth", "definition": "Any process that activates or increases the frequency, rate or extent of imaginal disc growth. [GOC:go_curators]"}
{"concept_id": "C1160292", "aliases": ["morphogenesis of structures derived from the clypeo-labral disc", "clypeo-labral disc metamorphosis"], "types": ["T042"], "canonical_name": "clypeo-labral disc morphogenesis", "definition": "The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160293", "aliases": [], "types": ["T042"], "canonical_name": "proboscis morphogenesis", "definition": "The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head. [GOC:jid, GOC:rc]"}
{"concept_id": "C1160294", "aliases": ["eye-antennal disc metamorphosis"], "types": ["T042"], "canonical_name": "eye-antennal disc morphogenesis", "definition": "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160296", "aliases": ["genital disc metamorphosis"], "types": ["T042"], "canonical_name": "genital disc morphogenesis", "definition": "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160297", "aliases": ["haltere disc metamorphosis"], "types": ["T042"], "canonical_name": "haltere disc morphogenesis", "definition": "The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160298", "aliases": ["histoblast metamorphosis"], "types": ["T042"], "canonical_name": "histoblast morphogenesis", "definition": "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160299", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of imaginal histoblast diploidy", "definition": "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160300", "aliases": ["labial disc metamorphosis"], "types": ["T042"], "canonical_name": "labial disc morphogenesis", "definition": "The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160301", "aliases": ["leg disc metamorphosis"], "types": ["T042"], "canonical_name": "leg disc morphogenesis", "definition": "The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160302", "aliases": [], "types": ["T042"], "canonical_name": "leg disc proximal/distal pattern formation", "definition": "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg. [GOC:bf]"}
{"concept_id": "C1160303", "aliases": ["prothoracic disc metamorphosis"], "types": ["T042"], "canonical_name": "prothoracic disc morphogenesis", "definition": "The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160304", "aliases": ["wing disc metamorphosis"], "types": ["T042"], "canonical_name": "wing disc morphogenesis", "definition": "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1160305", "aliases": [], "types": ["T042"], "canonical_name": "wing disc proximal/distal pattern formation", "definition": "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing. [GOC:bf]"}
{"concept_id": "C1160306", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc pattern formation", "definition": "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. [GOC:dph, GOC:isa_complete, GOC:jid]"}
{"concept_id": "C1160308", "aliases": ["dorsoventral pattern formation, imaginal disc", "dorsal-ventral pattern formation, imaginal disc"], "types": ["T042"], "canonical_name": "dorsal/ventral pattern formation, imaginal disc", "definition": "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed. [GOC:jid, ISBN:0879694238]"}
{"concept_id": "C1160309", "aliases": ["dorsoventral lineage restriction, imaginal disc", "dorsal-ventral lineage restriction, imaginal disc"], "types": ["T042"], "canonical_name": "dorsal/ventral lineage restriction, imaginal disc", "definition": "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment. [GOC:bf, PMID:10625531, PMID:9374402]"}
{"concept_id": "C1160310", "aliases": [], "types": ["T042"], "canonical_name": "proximal/distal pattern formation, imaginal disc", "definition": "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed. [GOC:jid, ISBN:0879694238]"}
{"concept_id": "C1160311", "aliases": ["hemopoietic organ development", "haemopoietic organ development", "hematopoietic organ development", "lymph gland development", "haematopoietic organ development"], "types": ["T042"], "canonical_name": "lymph node development", "definition": "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. [GOC:add, ISBN:068340007X, ISBN:0781735149]"}
{"concept_id": "C1160312", "aliases": [], "types": ["T042"], "canonical_name": "midgut development", "definition": "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. [GOC:jid, UBERON:0001045]"}
{"concept_id": "C1160313", "aliases": [], "types": ["T042"], "canonical_name": "anterior midgut development", "definition": "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1160314", "aliases": [], "types": ["T042"], "canonical_name": "posterior midgut development", "definition": "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1160315", "aliases": ["visceral mesoderm/endoderm interaction"], "types": ["T042"], "canonical_name": "visceral mesoderm-endoderm interaction involved in midgut development", "definition": "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut. [GOC:dph, GOC:isa_complete]"}
{"concept_id": "C1160317", "aliases": [], "types": ["T042"], "canonical_name": "determination of muscle attachment site", "definition": "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site. [GOC:isa_complete]"}
{"concept_id": "C1160320", "aliases": [], "types": ["T042"], "canonical_name": "myoblast fusion", "definition": "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:mtg_muscle]"}
{"concept_id": "C1160321", "aliases": [], "types": ["T042"], "canonical_name": "myofibril assembly", "definition": "Formation of myofibrils, the repeating units of striated muscle. [GOC:mah]"}
{"concept_id": "C1160323", "aliases": ["sarcomere organisation", "sarcomere alignment"], "types": ["T040"], "canonical_name": "sarcomere organization", "definition": "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. [GOC:bf]"}
{"concept_id": "C1160324", "aliases": ["neuromuscular junction organization"], "types": ["T042"], "canonical_name": "neuromuscular junction development", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. [GOC:mtg_OBO2OWL_2013]"}
{"concept_id": "C1160325", "aliases": [], "types": ["T042"], "canonical_name": "establishment of synaptic specificity at neuromuscular junction", "definition": "The biological process in which a synapse between a motor neuron and a muscle is initially formed. [GOC:isa_complete]"}
{"concept_id": "C1160326", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic growth at neuromuscular junction"}
{"concept_id": "C1160327", "aliases": [], "types": ["T042"], "canonical_name": "long-term strengthening of neuromuscular junction", "definition": "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse. [GO_REF:0000021]"}
{"concept_id": "C1160328", "aliases": ["negative regulation of synaptic growth at neuromuscular junction", "downregulation of synaptic growth at neuromuscular junction", "down-regulation of synaptic growth at neuromuscular junction", "down regulation of synaptic growth at neuromuscular junction"], "types": ["T040"], "canonical_name": "negative regulation of synaptic assembly at neuromuscular junction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic assembly at neuromuscular junction. [GOC:go_curators]"}
{"concept_id": "C1160329", "aliases": ["upregulation of synaptic growth at neuromuscular junction", "up-regulation of synaptic growth at neuromuscular junction", "positive regulation of synaptic growth at neuromuscular junction", "up regulation of synaptic growth at neuromuscular junction"], "types": ["T040"], "canonical_name": "positive regulation of synaptic assembly at neuromuscular junction", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction. [GOC:go_curators]"}
{"concept_id": "C1160333", "aliases": [], "types": ["T042"], "canonical_name": "somatic muscle development", "definition": "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle. [GOC:jid, GOC:mtg_muscle]"}
{"concept_id": "C1160334", "aliases": [], "types": ["T042"], "canonical_name": "adult somatic muscle development", "definition": "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1160335", "aliases": [], "types": ["T042"], "canonical_name": "visceral muscle development", "definition": "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1160336", "aliases": [], "types": ["T042"], "canonical_name": "adult visceral muscle development", "definition": "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1160337", "aliases": ["neuron long process generation", "axon morphogenesis"], "types": ["T042"], "canonical_name": "axonogenesis", "definition": "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]"}
{"concept_id": "C1160338", "aliases": [], "types": ["T043"], "canonical_name": "axon target recognition", "definition": "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections. [ISBN:0878932437]"}
{"concept_id": "C1160339", "aliases": ["CNS development"], "types": ["T042"], "canonical_name": "central nervous system development", "definition": "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GOC:bf, GOC:jid, ISBN:0582227089]"}
{"concept_id": "C1160340", "aliases": [], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]", "canonical_name": "brain development"}
{"concept_id": "C1160341", "aliases": [], "types": ["T040"], "canonical_name": "mushroom body development", "definition": "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells. [PMID:8790424]"}
{"concept_id": "C1160342", "aliases": [], "types": ["T042"], "canonical_name": "ventral cord development", "definition": "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms. [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]"}
{"concept_id": "C1160343", "aliases": [], "types": ["T040"], "canonical_name": "ventral midline development", "definition": "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate. [GOC:bf, GOC:go_curators, PMID:12075342]"}
{"concept_id": "C1160344", "aliases": [], "types": ["T042"], "canonical_name": "axonal defasciculation", "definition": "Separation of axons away from a bundle of axons known as a fascicle. [GOC:dgh, ISBN:039751820X]"}
{"concept_id": "C1160347", "aliases": [], "types": ["T042"], "canonical_name": "ganglion mother cell fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators]"}
{"concept_id": "C1160348", "aliases": ["establishment of blood/nerve barrier"], "types": ["T042"], "canonical_name": "establishment of blood-nerve barrier", "definition": "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier. [GOC:dgh]"}
{"concept_id": "C1160349", "aliases": [], "types": ["T040"], "definition": "The collection of axons into a bundle of rods, known as a fascicle. [GOC:dgh]", "canonical_name": "axonal fasciculation"}
{"concept_id": "C1160350", "aliases": ["glial cell generation"], "types": ["T042"], "canonical_name": "gliogenesis", "definition": "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. [GOC:dgh, GOC:jid]"}
{"concept_id": "C1160353", "aliases": ["regulation of neuroglia differentiation", "regulation of glia cell differentiation"], "types": ["T043"], "canonical_name": "regulation of glial cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of glia cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1160354", "aliases": ["down-regulation of glial cell differentiation", "negative regulation of neuroglia differentiation", "negative regulation of glia cell differentiation", "downregulation of glial cell differentiation", "down regulation of glial cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of glial cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1160355", "aliases": ["up-regulation of glial cell differentiation", "up regulation of glial cell differentiation", "upregulation of glial cell differentiation", "positive regulation of neuroglia differentiation", "positive regulation of glia cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of glial cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of glia cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1160357", "aliases": [], "types": ["T042"], "canonical_name": "perineurial glial growth", "definition": "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons. [GOC:mah, PMID:11517334, PMID:18176560]"}
{"concept_id": "C1160359", "aliases": ["voltage-gated potassium channel clustering", "Kv channel clustering", "clustering of voltage-dependent potassium channels", "clustering of voltage gated potassium channels"], "types": ["T043"], "canonical_name": "clustering of voltage-gated potassium channels", "definition": "The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode. [PMID:11456440]"}
{"concept_id": "C1160360", "aliases": ["clustering of voltage-dependent sodium channels", "Nav channel clustering", "clustering of voltage gated sodium channels", "voltage-gated sodium channel clustering"], "types": ["T043"], "canonical_name": "clustering of voltage-gated sodium channels", "definition": "The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization. [PMID:11456440]"}
{"concept_id": "C1160362", "aliases": [], "types": ["T042"], "canonical_name": "nerve ensheathment"}
{"concept_id": "C1160364", "aliases": ["neuroblast cell fate determination", "neuroblast identity determination"], "types": ["T043"], "canonical_name": "neuroblast fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus. [GOC:go_curators]"}
{"concept_id": "C1160365", "aliases": [], "types": ["T042"], "canonical_name": "neuroblast proliferation", "definition": "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. [GOC:ai, GOC:mtg_sensu, GOC:sart]"}
{"concept_id": "C1160367", "aliases": ["neuronal remodeling"], "types": ["T042"], "definition": "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. [GOC:hb]", "canonical_name": "neuron remodeling"}
{"concept_id": "C1160368", "aliases": ["pan-neural process"], "types": ["T042"], "canonical_name": "pan-neural process", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1160369", "aliases": [], "types": ["T042"], "canonical_name": "peripheral nervous system development", "definition": "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. [GOC:go_curators, UBERON:0000010]"}
{"concept_id": "C1160370", "aliases": ["sense organ development"], "types": ["T042"], "canonical_name": "sensory organ development", "definition": "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1160372", "aliases": ["sense organ precursor cell fate determination"], "types": ["T043"], "canonical_name": "sensory organ precursor cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators]"}
{"concept_id": "C1160373", "aliases": [], "types": ["T042"], "canonical_name": "sex comb development", "definition": "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg. [http://fly.ebi.ac.uk]"}
{"concept_id": "C1160374", "aliases": [], "types": ["T040"], "canonical_name": "stomatogastric nervous system development", "definition": "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1160375", "aliases": ["suppression of neuroblast proliferation", "down regulation of neuroblast proliferation", "downregulation of neuroblast proliferation", "down-regulation of neuroblast proliferation"], "types": ["T042"], "canonical_name": "negative regulation of neuroblast proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. [GOC:ai]"}
{"concept_id": "C1160376", "aliases": [], "types": ["T042"], "canonical_name": "neuroblast activation", "definition": "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1160377", "aliases": [], "types": ["T042"], "canonical_name": "odontogenesis of calcareous or chitinous tooth"}
{"concept_id": "C1160381", "aliases": ["odontogenesis of dentine-containing teeth", "odontogenesis of dentine-containing tooth"], "types": ["T042"], "canonical_name": "odontogenesis of dentin-containing tooth", "definition": "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]"}
{"concept_id": "C1160382", "aliases": ["regulation of odontogenesis of dentine-containing tooth", "regulation of odontogenesis of dentine-containing teeth"], "types": ["T042"], "canonical_name": "regulation of odontogenesis of dentin-containing tooth", "definition": "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. [GOC:jl, GOC:mtg_sensu, PMID:15355794]"}
{"concept_id": "C1160383", "aliases": ["negative regulation of odontogenesis of dentine-containing tooth", "negative regulation of odontogenesis of dentine-containing teeth"], "types": ["T042"], "canonical_name": "negative regulation of odontogenesis of dentin-containing tooth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx. [GOC:jl, GOC:mtg_sensu, PMID:15355794]"}
{"concept_id": "C1160384", "aliases": ["positive regulation of odontogenesis of dentine-containing teeth", "positive regulation of odontogenesis of dentine-containing tooth"], "types": ["T042"], "canonical_name": "positive regulation of odontogenesis of dentin-containing tooth", "definition": "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. [GOC:jl, PMID:15355794]"}
{"concept_id": "C1160385", "aliases": ["regulation of tooth development"], "types": ["T042"], "canonical_name": "regulation of odontogenesis", "definition": "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. [GOC:jl]"}
{"concept_id": "C1160386", "aliases": ["negative regulation of odontogenesis", "down regulation of odontogenesis", "downregulation of odontogenesis", "negative regulation of tooth development", "down-regulation of odontogenesis"], "types": ["T042"], "canonical_name": "negative regulation of odontogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth. [GOC:jl]"}
{"concept_id": "C1160387", "aliases": ["up regulation of odontogenesis", "up-regulation of odontogenesis", "upregulation of odontogenesis", "positive regulation of tooth development"], "types": ["T042"], "canonical_name": "positive regulation of odontogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth. [GOC:jl]"}
{"concept_id": "C1160388", "aliases": [], "types": ["T042"], "canonical_name": "respiratory tube development", "definition": "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. [GOC:jid]"}
{"concept_id": "C1160389", "aliases": [], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. [GOC:jid, UBERON:0002048]", "canonical_name": "lung development"}
{"concept_id": "C1160390", "aliases": [], "types": ["T042"], "canonical_name": "salivary gland development", "definition": "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. [GOC:jid, UBERON:0001044]"}
{"concept_id": "C1160391", "aliases": ["salivary gland determination"], "types": ["T042"], "canonical_name": "salivary gland boundary specification", "definition": "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. [PMID:11598957]"}
{"concept_id": "C1160393", "aliases": ["regulation of adult salivary gland determination"], "types": ["T040"], "canonical_name": "regulation of adult salivary gland boundary specification", "definition": "Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160394", "aliases": ["negative regulation of adult salivary gland determination", "down regulation of adult salivary gland determination", "downregulation of adult salivary gland determination", "down-regulation of adult salivary gland determination"], "types": ["T040"], "canonical_name": "negative regulation of adult salivary gland boundary specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in an adult organism. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160395", "aliases": ["up-regulation of adult salivary gland determination", "positive regulation of adult salivary gland determination", "upregulation of adult salivary gland determination", "up regulation of adult salivary gland determination"], "types": ["T040"], "canonical_name": "positive regulation of adult salivary gland boundary specification", "definition": "Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160396", "aliases": ["regulation of salivary gland determination"], "types": ["T040"], "canonical_name": "regulation of salivary gland boundary specification", "definition": "Any process that modulates the frequency, rate or extent of salivary gland determination. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160397", "aliases": ["downregulation of salivary gland determination", "down regulation of salivary gland determination", "negative regulation of salivary gland determination", "down-regulation of salivary gland determination"], "types": ["T040"], "canonical_name": "negative regulation of salivary gland boundary specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160398", "aliases": ["positive regulation of salivary gland determination", "up-regulation of salivary gland determination", "upregulation of salivary gland determination", "up regulation of salivary gland determination"], "types": ["T040"], "canonical_name": "positive regulation of salivary gland boundary specification", "definition": "Any process that activates or increases the frequency, rate or extent of salivary gland determination. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160399", "aliases": [], "types": ["T042"], "canonical_name": "salivary gland morphogenesis", "definition": "The process in which the anatomical structures of the salivary gland are generated and organized. [GOC:jid]"}
{"concept_id": "C1160400", "aliases": [], "types": ["T042"], "canonical_name": "adult salivary gland morphogenesis", "definition": "The process in which the anatomical structures of the adult salivary gland are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1160401", "aliases": ["skeletal system development"], "types": ["T040"], "definition": "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). [GOC:dph, GOC:jid, GOC:tb]", "canonical_name": "skeletal development"}
{"concept_id": "C1160402", "aliases": [], "types": ["T042"], "canonical_name": "cartilage condensation", "definition": "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. [ISBN:0878932437]"}
{"concept_id": "C1160403", "aliases": [], "types": ["T042"], "canonical_name": "regulation of bone mineralization", "definition": "Any process that modulates the frequency, rate or extent of bone mineralization. [GOC:go_curators]"}
{"concept_id": "C1160404", "aliases": ["downregulation of bone mineralization", "down regulation of bone mineralization", "down-regulation of bone mineralization"], "types": ["T042"], "canonical_name": "negative regulation of bone mineralization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. [GOC:go_curators]"}
{"concept_id": "C1160405", "aliases": ["up regulation of bone mineralization", "upregulation of bone mineralization", "up-regulation of bone mineralization"], "types": ["T042"], "canonical_name": "positive regulation of bone mineralization", "definition": "Any process that activates or increases the frequency, rate or extent of bone mineralization. [GOC:go_curators]"}
{"concept_id": "C1160406", "aliases": ["regulation of bone biosynthesis", "regulation of bone formation"], "types": ["T042"], "canonical_name": "regulation of ossification", "definition": "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]"}
{"concept_id": "C1160407", "aliases": ["downregulation of ossification", "negative regulation of bone formation", "negative regulation of bone biosynthesis", "down-regulation of ossification", "down regulation of ossification"], "types": ["T042"], "canonical_name": "negative regulation of ossification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]"}
{"concept_id": "C1160408", "aliases": ["up-regulation of ossification", "positive regulation of bone biosynthesis", "upregulation of ossification", "up regulation of ossification", "positive regulation of bone formation"], "types": ["T042"], "canonical_name": "positive regulation of ossification", "definition": "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]"}
{"concept_id": "C1160409", "aliases": [], "types": ["T042"], "canonical_name": "open tracheal system development", "definition": "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:8625828]"}
{"concept_id": "C1160415", "aliases": [], "types": ["T042"], "canonical_name": "urogenital system development", "definition": "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1160416", "aliases": [], "types": ["T042"], "canonical_name": "metanephros development", "definition": "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:bf, ISBN:0192800752]"}
{"concept_id": "C1160417", "aliases": [], "types": ["T042"], "canonical_name": "ureteric bud development", "definition": "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1160418", "aliases": ["ureteric bud branching"], "types": ["T040"], "canonical_name": "branching involved in ureteric bud morphogenesis", "definition": "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. [GOC:dph, PMID:16916378]"}
{"concept_id": "C1160419", "aliases": ["post-embryonic morphogenesis of an anatomical structure"], "types": ["T040"], "canonical_name": "post-embryonic animal morphogenesis", "definition": "The process, occurring after animal embryonic development, by which anatomical structures are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1160421", "aliases": [], "types": ["T040"], "definition": "Pattern Formation is a developmental morphogenetic process that establishes basic configurations of cellular organization necessary for further and accurate development of the spatial arrangements of embryonic tissue.", "canonical_name": "pattern formation"}
{"concept_id": "C1160422", "aliases": [], "types": ["T043"], "canonical_name": "adaxial/abaxial pattern formation"}
{"concept_id": "C1160423", "aliases": ["adaxial/abaxial determination"], "types": ["T040"], "canonical_name": "adaxial/abaxial axis specification", "definition": "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure. [GOC:dph, GOC:tb]"}
{"concept_id": "C1160424", "aliases": [], "types": ["T040"], "canonical_name": "polarity specification of adaxial/abaxial axis", "definition": "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure. [GOC:dph, GOC:tb]"}
{"concept_id": "C1160425", "aliases": [], "types": ["T042"], "canonical_name": "anterior/posterior pattern formation"}
{"concept_id": "C1160426", "aliases": ["anterior/posterior axis determination"], "types": ["T040"], "canonical_name": "anterior/posterior axis specification", "definition": "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160427", "aliases": ["oocyte anterior/posterior axis determination"], "types": ["T043"], "canonical_name": "oocyte anterior/posterior axis specification", "definition": "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster. [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]"}
{"concept_id": "C1160428", "aliases": [], "types": ["T043"], "canonical_name": "pole plasm assembly", "definition": "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu]"}
{"concept_id": "C1160429", "aliases": [], "types": ["T040"], "canonical_name": "polarity specification of anterior/posterior axis", "definition": "Any process resulting in the establishment of polarity along the anterior/posterior axis. [GOC:go_curators]"}
{"concept_id": "C1160430", "aliases": ["axis determination"], "types": ["T040"], "canonical_name": "axis specification", "definition": "The establishment, maintenance and elaboration of a pattern along a line or around a point. [GOC:dph, GOC:go_curators, GOC:isa_complete]"}
{"concept_id": "C1160431", "aliases": ["mediolateral axis specification", "centrolateral axis determination"], "types": ["T040"], "canonical_name": "centrolateral axis specification", "definition": "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf. [GOC:dsz, GOC:tb, ISBN:0865427429]"}
{"concept_id": "C1160432", "aliases": ["dorsal/ventral axis determination", "dorsoventral axis specification", "dorsal-ventral axis specification"], "types": ["T040"], "canonical_name": "dorsal/ventral axis specification", "definition": "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160433", "aliases": ["oocyte dorsal/ventral axis determination", "oocyte dorsal-ventral axis specification", "oocyte dorsoventral axis specification"], "types": ["T043"], "canonical_name": "oocyte dorsal/ventral axis specification", "definition": "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1160434", "aliases": ["maternal specification of dorsal-ventral axis, oocyte, germ-line encoded", "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded", "maternal specification of dorsoventral axis, oocyte, germ-line encoded"], "types": ["T043"], "canonical_name": "maternal specification of dorsal/ventral axis, oocyte, germ-line encoded", "definition": "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster. [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]"}
{"concept_id": "C1160436", "aliases": ["maternal specification of dorsoventral axis, oocyte, soma encoded", "maternal specification of dorsal-ventral axis, oocyte, soma encoded", "maternal determination of dorsal/ventral axis, oocyte, soma encoded"], "types": ["T043"], "canonical_name": "maternal specification of dorsal/ventral axis, oocyte, soma encoded", "definition": "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster. [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]"}
{"concept_id": "C1160437", "aliases": ["polarity specification of dorsoventral axis", "polarity specification of dorsal-ventral axis"], "types": ["T040"], "canonical_name": "polarity specification of dorsal/ventral axis", "definition": "Any process resulting in the establishment of polarity along the dorsal/ventral axis. [GOC:go_curators]"}
{"concept_id": "C1160438", "aliases": ["apical-basal pattern specification", "longitudinal axis determination"], "types": ["T040"], "canonical_name": "longitudinal axis specification", "definition": "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root. [GOC:tb]"}
{"concept_id": "C1160439", "aliases": ["oocyte axis determination"], "types": ["T043"], "canonical_name": "oocyte axis specification", "definition": "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1160440", "aliases": ["proximodistal axis specification", "proximal/distal axis determination"], "types": ["T040"], "canonical_name": "proximal/distal axis specification", "definition": "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1160441", "aliases": [], "types": ["T040"], "canonical_name": "radial axis specification", "definition": "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point. [GOC:dph, GOC:go_curators, GOC:isa_complete]"}
{"concept_id": "C1160442", "aliases": ["compartment specification"], "types": ["T040"], "canonical_name": "compartment pattern specification", "definition": "The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160444", "aliases": [], "types": ["T040"], "canonical_name": "posterior compartment specification", "definition": "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1160446", "aliases": ["determination of bilateral asymmetry"], "types": ["T040"], "canonical_name": "determination of bilateral symmetry", "definition": "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. [GOC:go_curators]"}
{"concept_id": "C1160448", "aliases": ["determination of radial asymmetry"], "types": ["T040"], "canonical_name": "determination of radial symmetry", "definition": "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis. [GOC:go_curators]"}
{"concept_id": "C1160449", "aliases": ["dorsal-ventral pattern formation", "dorsal/ventral pattern formation"], "types": ["T042"], "definition": "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]", "canonical_name": "dorsoventral pattern formation"}
{"concept_id": "C1160451", "aliases": [], "types": ["T042"], "canonical_name": "proximal/distal pattern formation", "definition": "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). [GOC:dph, GOC:go_curators, GOC:isa_complete]"}
{"concept_id": "C1160452", "aliases": [], "types": ["T042"], "canonical_name": "radial pattern specification"}
{"concept_id": "C1160453", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic development", "definition": "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. [GOC:go_curators]"}
{"concept_id": "C1160454", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gene expression, epigenetic", "definition": "A process that modulates the frequency, rate or extent of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]"}
{"concept_id": "C1160455", "aliases": [], "types": ["T045"], "canonical_name": "dosage compensation by hyperactivation of X chromosome", "definition": "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster. [GOC:jl, GOC:mr, ISBN:0140512888, PMID:11498577, PMID:20622855, Wikipedia:XY_sex-determination_system]"}
{"concept_id": "C1160457", "aliases": [], "types": ["T045"], "canonical_name": "dosage compensation by hypoactivation of X chromosome", "definition": "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans. [GOC:jl, GOC:mr, PMID:11102361, PMID:20622855, Wikipedia:XY_sex-determination_system]"}
{"concept_id": "C1160461", "aliases": ["down regulation of gene expression, epigenetic", "down-regulation of gene expression, epigenetic", "downregulation of gene expression, epigenetic"], "types": ["T045"], "canonical_name": "negative regulation of gene expression, epigenetic", "definition": "An epigenetic process that stops, prevents or reduces the rate of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. [PMID:22243696]"}
{"concept_id": "C1160463", "aliases": ["positive regulation of gene expression, epigenetic", "up regulation of gene expression, epigenetic", "maintenance of chromatin in transcription-competent conformation", "up-regulation of gene expression, epigenetic", "chromatin-mediated maintenance of transcription", "upregulation of gene expression, epigenetic"], "types": ["T045"], "canonical_name": "epigenetic maintenance of chromatin in transcription-competent conformation", "definition": "An epigenetic process that capacitates gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. [PMID:34414474]"}
{"concept_id": "C1160468", "aliases": ["conjugation without cellular fusion"], "types": ["T043"], "canonical_name": "conjugation with mutual genetic exchange", "definition": "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange. [GOC:elh, PMID:22444146]"}
{"concept_id": "C1160469", "aliases": [], "types": ["T043"], "canonical_name": "conjugant formation", "definition": "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing. [GOC:elh]"}
{"concept_id": "C1160470", "aliases": [], "types": ["T043"], "canonical_name": "double fertilization forming two zygotes", "definition": "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis. [GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C1160471", "aliases": ["double fertilization"], "types": ["T043"], "canonical_name": "double fertilization forming a zygote and endosperm", "definition": "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana. [GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C1160473", "aliases": [], "types": ["T043"], "canonical_name": "binding of sperm to zona pellucida", "definition": "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. [GOC:dph, ISBN:0878932437]"}
{"concept_id": "C1160474", "aliases": [], "types": ["T043"], "canonical_name": "egg activation", "definition": "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. [GOC:bf, PMID:9630751]"}
{"concept_id": "C1160475", "aliases": [], "types": ["T043"], "canonical_name": "penetration of zona pellucida", "definition": "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]"}
{"concept_id": "C1160477", "aliases": ["female gametophyte development"], "types": ["T042"], "canonical_name": "embryo sac development", "definition": "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate. [GOC:mtg_plant, GOC:tb]"}
{"concept_id": "C1160478", "aliases": [], "types": ["T043"], "canonical_name": "antipodal cell differentiation", "definition": "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell. [GOC:jid, GOC:mtg_plant]"}
{"concept_id": "C1160479", "aliases": [], "types": ["T043"], "canonical_name": "regulation of antipodal cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of antipodal cell differentiation. [GOC:go_curators, GOC:mtg_plant]"}
{"concept_id": "C1160480", "aliases": ["down-regulation of antipodal cell differentiation", "downregulation of antipodal cell differentiation", "down regulation of antipodal cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of antipodal cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation. [GOC:go_curators, GOC:mtg_plant]"}
{"concept_id": "C1160481", "aliases": ["up regulation of antipodal cell differentiation", "upregulation of antipodal cell differentiation", "up-regulation of antipodal cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of antipodal cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation. [GOC:go_curators, GOC:mtg_plant]"}
{"concept_id": "C1160482", "aliases": ["cellularization of the embryo sac", "female gametophyte cellularization", "megagametophyte cellularization"], "types": ["T043"], "canonical_name": "embryo sac cellularization", "definition": "The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana. [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X]"}
{"concept_id": "C1160483", "aliases": ["embryo sac endosperm mother cell differentiation", "female gametophyte central cell differentiation"], "types": ["T043"], "canonical_name": "embryo sac central cell differentiation", "definition": "The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell. [GOC:jid, GOC:mtg_plant]"}
{"concept_id": "C1160484", "aliases": ["regulation of female gametophyte central cell differentiation"], "types": ["T043"], "canonical_name": "regulation of embryo sac central cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation. [GOC:go_curators, GOC:mtg_plant]"}
{"concept_id": "C1160485", "aliases": ["down regulation of female gametophyte central cell differentiation", "down-regulation of female gametophyte central cell differentiation", "downregulation of female gametophyte central cell differentiation", "negative regulation of female gametophyte central cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of embryo sac central cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation. [GOC:go_curators, GOC:mtg_plant]"}
{"concept_id": "C1160486", "aliases": ["positive regulation of female gametophyte central cell differentiation", "upregulation of female gametophyte central cell differentiation", "up-regulation of female gametophyte central cell differentiation", "up regulation of female gametophyte central cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of embryo sac central cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation. [GOC:go_curators, GOC:mtg_plant]"}
{"concept_id": "C1160487", "aliases": ["female gametophyte egg cell differentiation"], "types": ["T043"], "canonical_name": "embryo sac egg cell differentiation", "definition": "The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana. [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu]"}
{"concept_id": "C1160488", "aliases": ["regulation of female gametophyte egg cell differentiation"], "types": ["T043"], "canonical_name": "regulation of embryo sac egg cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation. [GOC:go_curators, GOC:mtg_plant]"}
{"concept_id": "C1160489", "aliases": ["downregulation of female gametophyte egg cell differentiation", "down regulation of female gametophyte egg cell differentiation", "down-regulation of female gametophyte egg cell differentiation", "negative regulation of female gametophyte egg cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of embryo sac egg cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation. [GOC:go_curators, GOC:mtg_plant]"}
{"concept_id": "C1160490", "aliases": ["up regulation of female gametophyte egg cell differentiation", "positive regulation of female gametophyte egg cell differentiation", "upregulation of female gametophyte egg cell differentiation", "up-regulation of female gametophyte egg cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of embryo sac egg cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation. [GOC:go_curators, GOC:mtg_plant]"}
{"concept_id": "C1160491", "aliases": ["megagametophyte nucleus division", "embryo sac development from the megaspore"], "types": ["T043"], "canonical_name": "megagametogenesis", "definition": "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. [GOC:jl, GOC:mtg_plant]"}
{"concept_id": "C1160492", "aliases": ["female gametophyte nuclear migration", "megagametophyte nuclear migration", "embryo sac nucleus migration", "megagametophyte nucleus migration", "female gametophyte nucleus migration"], "types": ["T043"], "canonical_name": "embryo sac nuclear migration", "definition": "The directed movement of an embryo sac nucleus to the pole or center of the cell. [GOC:jl, GOC:mtg_plant]"}
{"concept_id": "C1160493", "aliases": ["synergid cell differentiation"], "types": ["T043"], "canonical_name": "synergid differentiation", "definition": "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell. [GOC:jid]"}
{"concept_id": "C1160494", "aliases": ["regulation of synergid cell differentiation"], "types": ["T043"], "canonical_name": "regulation of synergid differentiation", "definition": "Any process that modulates the frequency, rate or extent of synergid cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1160495", "aliases": ["downregulation of synergid differentiation", "down-regulation of synergid differentiation", "down regulation of synergid differentiation", "negative regulation of synergid cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of synergid differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1160496", "aliases": ["up regulation of synergid differentiation", "up-regulation of synergid differentiation", "positive regulation of synergid cell differentiation", "upregulation of synergid differentiation"], "types": ["T043"], "canonical_name": "positive regulation of synergid differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of synergid cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1160497", "aliases": ["megasporogenesis", "meiosis of the megasporocyte", "megaspore mother cell meiosis", "meiotic division of the megasporocyte"], "types": ["T043"], "definition": "The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus. [GOC:mtg_plant, GOC:tb]", "canonical_name": "megaspore development"}
{"concept_id": "C1160498", "aliases": ["male gametophyte development", "pollen grain formation", "microgametophyte development", "male gametophyte formation", "formation of generative and vegetative cells"], "types": ["T043"], "canonical_name": "pollen development", "definition": "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates. [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C1160500", "aliases": ["microspore development"], "types": ["T042"], "definition": "The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores. [GOC:mtg_plant, GOC:tb]", "canonical_name": "microsporogenesis"}
{"concept_id": "C1160501", "aliases": ["germ-cell development"], "types": ["T043"], "canonical_name": "germ cell development", "definition": "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. [GOC:go_curators]"}
{"concept_id": "C1160510", "aliases": [], "types": ["T042"], "canonical_name": "insect chorion formation"}
{"concept_id": "C1160515", "aliases": [], "types": ["T043"], "canonical_name": "nurse cell nucleus anchoring", "definition": "Attachment of the nurse cell nucleus to the plasma membrane. [ISBN:0879694238]"}
{"concept_id": "C1160518", "aliases": ["oocyte arrangement"], "types": ["T043"], "canonical_name": "oocyte construction", "definition": "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732]"}
{"concept_id": "C1160520", "aliases": [], "types": ["T043"], "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/]", "canonical_name": "oocyte maturation"}
{"concept_id": "C1160521", "aliases": [], "types": ["T043"], "canonical_name": "pole cell development", "definition": "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1160523", "aliases": [], "types": ["T043"], "canonical_name": "pole cell formation", "definition": "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells. [GOC:bf, PMID:9988212]"}
{"concept_id": "C1160524", "aliases": [], "types": ["T043"], "canonical_name": "primary spermatocyte growth", "definition": "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis. [GOC:jid, ISBN:0879694238]"}
{"concept_id": "C1160526", "aliases": ["acrosome formation"], "types": ["T043"], "canonical_name": "acrosome assembly", "definition": "The formation of the acrosome from the spermatid Golgi. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C1160528", "aliases": [], "types": ["T043"], "canonical_name": "sperm individualization", "definition": "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane. [GOC:bf, PMID:9550716]"}
{"concept_id": "C1160529", "aliases": ["spermatid nuclear differentiation"], "types": ["T043"], "canonical_name": "spermatid nucleus differentiation", "definition": "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. [GOC:bf, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1160530", "aliases": [], "types": ["T043"], "canonical_name": "regulation of spermatid nuclear differentiation", "definition": "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation. [GOC:go_curators]"}
{"concept_id": "C1160531", "aliases": ["down regulation of spermatid nuclear differentiation", "downregulation of spermatid nuclear differentiation", "down-regulation of spermatid nuclear differentiation"], "types": ["T043"], "canonical_name": "negative regulation of spermatid nuclear differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation. [GOC:go_curators]"}
{"concept_id": "C1160532", "aliases": ["upregulation of spermatid nuclear differentiation", "up regulation of spermatid nuclear differentiation", "up-regulation of spermatid nuclear differentiation"], "types": ["T043"], "canonical_name": "positive regulation of spermatid nuclear differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation. [GOC:go_curators]"}
{"concept_id": "C1160533", "aliases": ["spermatid nuclear elongation"], "types": ["T043"], "canonical_name": "spermatid nucleus elongation", "definition": "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation. [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]"}
{"concept_id": "C1160534", "aliases": ["fruit maturation"], "types": ["T038"], "definition": "An developmental maturation process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal. [GOC:lr]", "canonical_name": "fruit ripening"}
{"concept_id": "C1160537", "aliases": [], "types": ["T040"], "canonical_name": "female sex determination", "definition": "The specification of female sex of an individual organism. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1160538", "aliases": ["sex determination, female germ-line determination"], "types": ["T040"], "canonical_name": "female germ-line sex determination", "definition": "The determination of sex and sexual phenotype in a female organism's germ line. [GOC:mah]"}
{"concept_id": "C1160539", "aliases": [], "types": ["T042"], "canonical_name": "female somatic sex determination", "definition": "The determination of sex and sexual phenotypes in a female organism's soma. [GOC:mah]"}
{"concept_id": "C1160540", "aliases": [], "types": ["T042"], "canonical_name": "germ-line sex determination", "definition": "The determination of sex and sexual phenotype in an organism's germ line. [GOC:ems]"}
{"concept_id": "C1160541", "aliases": [], "types": ["T040"], "canonical_name": "germ-line processes downstream of sex determination signal", "definition": "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways. [GOC:ems]"}
{"concept_id": "C1160542", "aliases": [], "types": ["T040"], "canonical_name": "hermaphrodite germ-line sex determination", "definition": "The determination of sex and sexual phenotype in the germ line of a hermaphrodite. [GOC:ems]"}
{"concept_id": "C1160544", "aliases": [], "types": ["T040"], "canonical_name": "feminization of hermaphroditic germ-line", "definition": "The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite. [GOC:ems]"}
{"concept_id": "C1160545", "aliases": [], "types": ["T040"], "canonical_name": "masculinization of hermaphroditic germ-line", "definition": "The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans. [GOC:ems]"}
{"concept_id": "C1160546", "aliases": [], "types": ["T042"], "canonical_name": "male germ-line sex determination", "definition": "The determination of sex and sexual phenotype in a male organism's germ line. [GOC:mah]"}
{"concept_id": "C1160547", "aliases": [], "types": ["T040"], "canonical_name": "primary sex determination, germ-line", "definition": "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line. [GOC:ems]"}
{"concept_id": "C1160549", "aliases": ["sex determination, somatic/gonadal interaction"], "types": ["T040"], "canonical_name": "sex determination, somatic-gonadal interaction", "definition": "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism. [GOC:isa_complete]"}
{"concept_id": "C1160550", "aliases": [], "types": ["T040"], "canonical_name": "male sex determination", "definition": "The specification of male sex of an individual organism. [GOC:mah]"}
{"concept_id": "C1160551", "aliases": [], "types": ["T042"], "canonical_name": "male somatic sex determination", "definition": "The determination of sex and sexual phenotypes in a male organism's soma. [GOC:mah]"}
{"concept_id": "C1160552", "aliases": [], "types": ["T040"], "canonical_name": "mating type determination", "definition": "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms. [http://www.biology-text.com/]"}
{"concept_id": "C1160553", "aliases": [], "types": ["T045"], "canonical_name": "mating type switching and recombination"}
{"concept_id": "C1160554", "aliases": [], "types": ["T043"], "definition": "The process that determines which donor locus a cell uses, in preference to another, in mating type switching. [GOC:mah, PMID:9928492]", "canonical_name": "donor selection"}
{"concept_id": "C1160555", "aliases": [], "types": ["T043"], "canonical_name": "activation of recombination (HML)", "definition": "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. [GOC:mah, PMID:9928492]"}
{"concept_id": "C1160556", "aliases": [], "types": ["T043"], "canonical_name": "inactivation of recombination (HML)", "definition": "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. [GOC:mah, PMID:9928492]"}
{"concept_id": "C1160557", "aliases": [], "types": ["T040"], "canonical_name": "primary sex determination", "definition": "The sex determination process that results in the initial specification of sexual status of an individual organism. [GOC:mah]"}
{"concept_id": "C1160558", "aliases": [], "types": ["T040"], "canonical_name": "primary sex determination, soma", "definition": "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma. [GOC:ems]"}
{"concept_id": "C1160559", "aliases": [], "types": ["T040"], "canonical_name": "sex determination, establishment of X:A ratio", "definition": "The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it. [GOC:isa_complete, GOC:mr, PMID:20622855, Wikipedia:XY_sex-determination_system]"}
{"concept_id": "C1160560", "aliases": [], "types": ["T040"], "canonical_name": "sex determination, primary response to X:A ratio", "definition": "The developmental process in which an organism interprets its X to autosomal chromosomal complement. [GOC:isa_complete]"}
{"concept_id": "C1160561", "aliases": [], "types": ["T040"], "canonical_name": "processes downstream of sex determination signal", "definition": "The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways. [GOC:mah]"}
{"concept_id": "C1160562", "aliases": [], "types": ["T040"], "canonical_name": "somatic processes downstream of sex determination signal", "definition": "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways. [GOC:ems]"}
{"concept_id": "C1160563", "aliases": [], "types": ["T042"], "canonical_name": "somatic sex determination", "definition": "The determination of sex and sexual phenotypes in an organism's soma. [GOC:ems]"}
{"concept_id": "C1160564", "aliases": [], "types": ["T040"], "canonical_name": "hermaphrodite somatic sex determination", "definition": "The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans. [GOC:ems]"}
{"concept_id": "C1160566", "aliases": [], "types": ["T040"], "canonical_name": "feminization of hermaphrodite soma", "definition": "Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans. [GOC:ems]"}
{"concept_id": "C1160567", "aliases": [], "types": ["T040"], "canonical_name": "masculinization of hermaphrodite soma", "definition": "Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans. [GOC:ems]"}
{"concept_id": "C1160568", "aliases": [], "types": ["T040"], "canonical_name": "development of primary sexual characteristics", "definition": "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. [GOC:ai]"}
{"concept_id": "C1160569", "aliases": [], "types": ["T040"], "canonical_name": "development of primary female sexual characteristics", "definition": "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. [GOC:ai]"}
{"concept_id": "C1160570", "aliases": [], "types": ["T040"], "canonical_name": "development of primary male sexual characteristics", "definition": "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion. [GOC:ai]"}
{"concept_id": "C1160571", "aliases": [], "types": ["T040"], "canonical_name": "development of secondary sexual characteristics", "definition": "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion. [GOC:ai]"}
{"concept_id": "C1160572", "aliases": [], "types": ["T040"], "canonical_name": "development of secondary female sexual characteristics", "definition": "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion. [GOC:ai]"}
{"concept_id": "C1160573", "aliases": [], "types": ["T040"], "canonical_name": "development of secondary male sexual characteristics", "definition": "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion. [GOC:ai]"}
{"concept_id": "C1160574", "aliases": [], "types": ["T040"], "canonical_name": "female sex differentiation", "definition": "The establishment of the sex of a female organism by physical differentiation. [GOC:bf]"}
{"concept_id": "C1160575", "aliases": [], "types": ["T040"], "canonical_name": "male sex differentiation", "definition": "The establishment of the sex of a male organism by physical differentiation. [GOC:bf]"}
{"concept_id": "C1160576", "aliases": [], "types": ["T040"], "canonical_name": "maintenance of pluripotency"}
{"concept_id": "C1160577", "aliases": [], "types": ["T043"], "definition": "The controlled release of acid by a cell or a tissue. [GOC:ai]", "canonical_name": "acid secretion"}
{"concept_id": "C1160578", "aliases": ["citrate secretion"], "types": ["T043"], "canonical_name": "citric acid secretion", "definition": "The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1160579", "aliases": ["formate secretion"], "types": ["T043"], "canonical_name": "formic acid secretion", "definition": "The controlled release of formic acid, HCOOH, by a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1160580", "aliases": [], "types": ["T042"], "canonical_name": "acetylcholine-induced gastric acid secretion", "definition": "The regulated release of gastric acid by parietal cells in response to acetylcholine. [GOC:hjd]"}
{"concept_id": "C1160581", "aliases": [], "types": ["T042"], "canonical_name": "gastrin-induced gastric acid secretion", "definition": "The regulated release of gastric acid induced by the interaction of gastrin with its receptor. [GOC:hjd]"}
{"concept_id": "C1160582", "aliases": [], "types": ["T042"], "canonical_name": "histamine-induced gastric acid secretion", "definition": "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP. [GOC:hjd]"}
{"concept_id": "C1160583", "aliases": ["lactate secretion"], "types": ["T043"], "canonical_name": "lactic acid secretion", "definition": "The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1160584", "aliases": ["hydroxysuccinic acid secretion", "malate secretion"], "types": ["T043"], "canonical_name": "malic acid secretion", "definition": "The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1160585", "aliases": ["oxalate secretion"], "types": ["T043"], "canonical_name": "oxalic acid secretion", "definition": "The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1160586", "aliases": [], "types": ["T040"], "canonical_name": "regulation of bone resorption", "definition": "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). [GOC:ai]"}
{"concept_id": "C1160587", "aliases": ["downregulation of bone resorption", "down-regulation of bone resorption", "down regulation of bone resorption"], "types": ["T040"], "canonical_name": "negative regulation of bone resorption", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. [GOC:go_curators]"}
{"concept_id": "C1160588", "aliases": ["upregulation of bone resorption", "up regulation of bone resorption", "up-regulation of bone resorption"], "types": ["T040"], "canonical_name": "positive regulation of bone resorption", "definition": "Any process that activates or increases the frequency, rate or extent of bone resorption. [GOC:go_curators]"}
{"concept_id": "C1160589", "aliases": [], "types": ["T043"], "canonical_name": "carbohydrate utilization", "definition": "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism. [GOC:mah, GOC:mcc2, GOC:mlg]"}
{"concept_id": "C1160590", "aliases": ["down-regulation of blood pressure", "downregulation of blood pressure", "down regulation of blood pressure"], "types": ["T040"], "canonical_name": "negative regulation of blood pressure", "definition": "Any process in which the force of blood traveling through the circulatory system is decreased. [GOC:go_curators, GOC:mtg_cardio]"}
{"concept_id": "C1160591", "aliases": ["upregulation of blood pressure", "up regulation of blood pressure", "up-regulation of blood pressure"], "types": ["T040"], "canonical_name": "positive regulation of blood pressure", "definition": "Any process in which the force of blood traveling through the circulatory system is increased. [GOC:go_curators, GOC:mtg_cardio]"}
{"concept_id": "C1160592", "aliases": ["regulation of heart contraction", "regulation of heart contraction rate", "cardiac chronotropy", "regulation of cardiac contraction", "regulation of heart rate"], "types": ["T039"], "definition": "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. [GOC:dph, GOC:go_curators, GOC:tb]", "canonical_name": "regulation of rate of heart contraction"}
{"concept_id": "C1160593", "aliases": ["down regulation of heart contraction", "downregulation of heart contraction", "down-regulation of heart contraction"], "types": ["T039"], "canonical_name": "negative regulation of heart contraction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. [GOC:go_curators]"}
{"concept_id": "C1160594", "aliases": ["positive regulation of cardiac contraction", "up-regulation of heart contraction", "upregulation of heart contraction", "up regulation of heart contraction"], "types": ["T039"], "canonical_name": "positive regulation of heart contraction", "definition": "Any process that activates or increases the frequency, rate or extent of heart contraction. [GOC:go_curators]"}
{"concept_id": "C1160595", "aliases": [], "types": ["T040"], "canonical_name": "regulation of vasoconstriction", "definition": "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. [GOC:jl]"}
{"concept_id": "C1160596", "aliases": ["downregulation of vasoconstriction", "down regulation of vasoconstriction", "down-regulation of vasoconstriction"], "types": ["T040"], "canonical_name": "negative regulation of vasoconstriction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction. [GOC:go_curators]"}
{"concept_id": "C1160597", "aliases": ["upregulation of vasoconstriction", "up regulation of vasoconstriction", "up-regulation of vasoconstriction"], "types": ["T040"], "canonical_name": "positive regulation of vasoconstriction", "definition": "Any process that activates or increases the frequency, rate or extent of vasoconstriction. [GOC:go_curators]"}
{"concept_id": "C1160601", "aliases": [], "types": ["T042"], "canonical_name": "anther dehiscence", "definition": "The dehiscence of an anther to release the pollen grains contained within it. [GOC:tb]"}
{"concept_id": "C1160606", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of gastrointestinal epithelium", "definition": "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. [GOC:mah]"}
{"concept_id": "C1160607", "aliases": [], "types": ["T042"], "canonical_name": "pancreatic juice secretion", "definition": "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1160609", "aliases": ["extracellular matrix organization and biogenesis", "extracellular matrix organisation"], "types": ["T043"], "canonical_name": "extracellular matrix organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. [GOC:mah]"}
{"concept_id": "C1160610", "aliases": ["collagen fibril organisation", "fibrillar collagen organization"], "types": ["T042"], "canonical_name": "collagen fibril organization", "definition": "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1160611", "aliases": [], "types": ["T044"], "canonical_name": "blood coagulation, extrinsic pathway", "definition": "A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X. [GOC:add, GOC:mah, GOC:pde]"}
{"concept_id": "C1160612", "aliases": [], "types": ["T044"], "canonical_name": "blood coagulation, intrinsic pathway", "definition": "A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. [GOC:add, GOC:mah, GOC:pde]"}
{"concept_id": "C1160613", "aliases": [], "types": ["T040"], "canonical_name": "regulation of blood coagulation", "definition": "Any process that modulates the frequency, rate or extent of blood coagulation. [GOC:mah]"}
{"concept_id": "C1160614", "aliases": ["downregulation of blood coagulation", "down regulation of blood coagulation", "down-regulation of blood coagulation"], "types": ["T040"], "canonical_name": "negative regulation of blood coagulation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation. [GOC:mah]"}
{"concept_id": "C1160615", "aliases": ["up regulation of blood coagulation", "up-regulation of blood coagulation", "upregulation of blood coagulation"], "types": ["T040"], "canonical_name": "positive regulation of blood coagulation", "definition": "Any process that activates or increases the frequency, rate or extent of blood coagulation. [GOC:mah]"}
{"concept_id": "C1160618", "aliases": [], "types": ["T040"], "canonical_name": "molting cycle", "definition": "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1160621", "aliases": [], "types": ["T042"], "canonical_name": "chitin-based cuticle attachment to epithelium", "definition": "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1160622", "aliases": [], "types": ["T042"], "canonical_name": "collagen and cuticulin-based cuticle attachment to epithelium", "definition": "Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans. [GOC:ems, GOC:mtg_sensu]"}
{"concept_id": "C1160624", "aliases": [], "types": ["T040"], "canonical_name": "ecdysis, chitin-based cuticle", "definition": "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1160625", "aliases": [], "types": ["T040"], "canonical_name": "ecdysis, collagen and cuticulin-based cuticle", "definition": "The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1160626", "aliases": ["chitin-based cuticle molting cycle"], "types": ["T040"], "canonical_name": "molting cycle, chitin-based cuticle", "definition": "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1160627", "aliases": [], "types": ["T040"], "definition": "The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells. [GOC:jl]", "canonical_name": "apolysis"}
{"concept_id": "C1160628", "aliases": ["puparial glue"], "types": ["T040"], "canonical_name": "puparial adhesion", "definition": "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation. [GOC:ma]"}
{"concept_id": "C1160629", "aliases": ["collagen and cuticulin-based cuticle molting cycle"], "types": ["T040"], "canonical_name": "molting cycle, collagen and cuticulin-based cuticle", "definition": "The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1160630", "aliases": ["nodule development", "nodule formation"], "types": ["T042"], "definition": "The formation of nitrogen-fixing root nodules on plant roots. [PMID:21856632, PMID:33317178]", "canonical_name": "nodulation"}
{"concept_id": "C1160632", "aliases": ["response to nutrients"], "types": ["T043"], "canonical_name": "response to nutrient", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:go_curators]"}
{"concept_id": "C1160635", "aliases": [], "types": ["T043"], "canonical_name": "pollen tube growth", "definition": "Growth of pollen via tip extension of the intine wall. [ISBN:0943088399]"}
{"concept_id": "C1160636", "aliases": ["respiratory gaseous exchange", "breathing", "respiratory system process"], "types": ["T038"], "definition": "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. [GOC:dph, GOC:mtg_cardio, GOC:tb]", "canonical_name": "respiration"}
{"concept_id": "C1160637", "aliases": ["regulation of osmotic pressure"], "types": ["T040"], "canonical_name": "water homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of water within an organism or cell. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1160638", "aliases": ["viral infectious cycle"], "types": ["T038"], "definition": "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. [ISBN:1555811272]", "canonical_name": "viral life cycle"}
{"concept_id": "C1160639", "aliases": ["lysogenic commitment"], "types": ["T038"], "canonical_name": "establishment of viral latency", "definition": "A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects. [GOC:jl]"}
{"concept_id": "C1160640", "aliases": ["provirus maintenance", "prophage maintenance", "latent virus maintenance"], "types": ["T043"], "canonical_name": "maintenance of viral latency", "definition": "The perpetuation of a latent state, generally by repressing the viruses own lytic genes expression and ensuring expression of viral genes which function to keep the viral genome from being detected by the host defense mechanisms. [GOC:jl]"}
{"concept_id": "C1160641", "aliases": [], "types": ["T043"], "canonical_name": "latent virus replication", "definition": "Any process required for latent viral replication in a cell. [ISBN:0781702534]"}
{"concept_id": "C1160643", "aliases": ["regulation of viral protein levels"], "types": ["T043"], "canonical_name": "regulation by virus of viral protein levels in host cell", "definition": "Any virus-mediated process that modulates the levels of viral proteins in a cell. [GOC:ai]"}
{"concept_id": "C1160644", "aliases": ["downregulation of viral protein levels in host cell", "down-regulation of viral protein levels in host cell", "negative regulation of viral protein levels", "down regulation of viral protein levels in host cell"], "types": ["T043"], "canonical_name": "negative regulation by virus of viral protein levels in host cell", "definition": "Any process where the infecting virus reduces the levels of viral proteins in a cell. [GOC:ai]"}
{"concept_id": "C1160645", "aliases": ["positive regulation of viral protein levels", "up regulation of viral protein levels in host cell", "up-regulation of viral protein levels in host cell", "upregulation of viral protein levels in host cell"], "types": ["T043"], "canonical_name": "positive regulation by virus of viral protein levels in host cell", "definition": "Any process where the infecting virus increases the levels of viral proteins in a cell. [GOC:ai]"}
{"concept_id": "C1160649", "aliases": ["virion attachment to host cell surface receptor", "viral absorption", "viral attachment to host cell"], "types": ["T043"], "canonical_name": "virion attachment to host cell", "definition": "The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection. [GOC:bf, GOC:jl, UniProtKB-KW:KW-1161, VZ:956]"}
{"concept_id": "C1160650", "aliases": ["virion attachment, binding of host cell surface coreceptor"], "types": ["T038"], "canonical_name": "coreceptor-mediated virion attachment to host cell", "definition": "The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface. [ISBN:0879694971]"}
{"concept_id": "C1160651", "aliases": ["virion attachment, binding of host cell surface receptor"], "types": ["T038"], "canonical_name": "receptor-mediated virion attachment to host cell", "definition": "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface. [ISBN:0879694971]"}
{"concept_id": "C1160657", "aliases": ["viral uncoating"], "types": ["T043"], "definition": "The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome. [GOC:plm, ISBN:0781702534, PMID:8162442]", "canonical_name": "uncoating of virus"}
{"concept_id": "C1160658", "aliases": [], "types": ["T043"], "canonical_name": "viral assembly, maturation, egress, and release"}
{"concept_id": "C1160663", "aliases": ["ER membrane viral budding", "endoplasmic reticulum membrane viral budding", "ER membrane viral budding during viral capsid envelopment", "viral budding from ER membrane", "virus budding from ER membrane", "virus budding from ER membrane during viral capsid envelopment", "viral budding from ER membrane during viral capsid envelopment", "endoplasmic reticulum membrane viral budding during viral capsid envelopment", "virus budding from ER membrane by viral capsid envelopment"], "types": ["T043"], "canonical_name": "viral budding from endoplasmic reticulum membrane", "definition": "A viral budding that starts with formation of a membrane curvature in the host ER membrane. [GOC:bf, GOC:jl, ISBN:0072370319, VZ:1947]"}
{"concept_id": "C1160668", "aliases": ["virus budding from Golgi membrane during viral capsid envelopment", "virus budding from Golgi membrane", "Golgi membrane viral budding during viral capsid envelopment", "viral budding from Golgi membrane by viral capsid envelopment", "virus budding from Golgi membrane by viral capsid envelopment", "Golgi membrane viral budding", "viral budding from Golgi membrane during viral capsid envelopment"], "types": ["T043"], "canonical_name": "viral budding from Golgi membrane", "definition": "A viral budding that starts with formation of a membrane curvature in the host Golgi membrane. [GOC:bf, ISBN:0072370319, VZ:1947]"}
{"concept_id": "C1160669", "aliases": ["virus budding from nuclear membrane by viral capsid envelopment", "virus budding from nuclear membrane", "viral budding from nuclear membrane during viral capsid envelopment", "nuclear membrane viral budding", "nuclear membrane viral budding during viral capsid envelopment", "virus budding from nuclear membrane during viral capsid envelopment"], "types": ["T043"], "canonical_name": "viral budding from nuclear membrane", "definition": "A viral budding that starts with formation of a membrane curvature in the host nuclear membrane. [GOC:bf, ISBN:0072370319]"}
{"concept_id": "C1160671", "aliases": ["virus budding from inner nuclear membrane during viral capsid envelopment", "viral budding from inner nuclear membrane during viral capsid envelopment"], "types": ["T043"], "canonical_name": "inner nuclear membrane viral budding during viral capsid envelopment"}
{"concept_id": "C1160672", "aliases": ["viral budding from outer nuclear membrane during viral capsid envelopment", "virus budding from outer nuclear membrane during viral capsid envelopment"], "types": ["T043"], "canonical_name": "outer nuclear membrane viral budding during viral capsid envelopment"}
{"concept_id": "C1160678", "aliases": ["plasma membrane viral budding", "viral budding from plasma membrane during viral capsid envelopment", "virus budding from plasma membrane by viral capsid envelopment", "virus budding from plasma membrane during viral capsid envelopment", "plasma membrane viral budding during viral capsid envelopment", "virus budding from plasma membrane"], "types": ["T038"], "canonical_name": "viral budding from plasma membrane", "definition": "A viral budding that starts with formation of a membrane curvature in the host plasma membrane. [GOC:bf, ISBN:0072370319, PMID:9394621, VZ:1947]"}
{"concept_id": "C1160680", "aliases": ["viral budding from plasma membrane during viral capsid re-envelopment", "virus budding from plasma membrane during viral capsid re-envelopment"], "types": ["T043"], "canonical_name": "plasma membrane viral budding during viral capsid re-envelopment"}
{"concept_id": "C1160682", "aliases": [], "types": ["T043"], "canonical_name": "viral capsid assembly", "definition": "The assembly of a virus capsid from its protein subunits. [ISBN:0781702534, UniProtKB-KW:KW-0118]"}
{"concept_id": "C1160683", "aliases": [], "types": ["T043"], "canonical_name": "viral capsid envelopment"}
{"concept_id": "C1160684", "aliases": ["virus budding from ER membrane during viral capsid re-envelopment", "virus budding from Golgi membrane by viral capsid re-envelopment", "virus budding from ER membrane by viral capsid re-envelopment", "viral budding from nuclear membrane by viral capsid re-envelopment", "virus budding from nuclear membrane by viral capsid re-envelopment", "viral budding from outer nuclear membrane by viral capsid re-envelopment", "viral budding from ER membrane by viral capsid re-envelopment", "viral budding from outer nuclear membrane during viral capsid re-envelopment", "nuclear membrane viral budding during viral capsid re-envelopment", "virus budding from inner nuclear membrane during viral capsid re-envelopment", "outer nuclear membrane viral budding during viral capsid re-envelopment", "viral budding from Golgi membrane by viral capsid re-envelopment", "ER membrane viral budding during viral capsid re-envelopment", "viral budding from inner nuclear membrane by viral capsid re-envelopment", "viral capsid re-envelopment", "viral budding from inner nuclear membrane during viral capsid re-envelopment", "virus budding from outer nuclear membrane by viral capsid re-envelopment", "inner nuclear membrane viral budding during viral capsid re-envelopment", "endoplasmic reticulum membrane viral budding during viral capsid re-envelopment", "viral budding from ER membrane during viral capsid re-envelopment", "virus budding from inner nuclear membrane by viral capsid re-envelopment", "viral budding from plasma membrane by viral capsid re-envelopment"], "types": ["T043"], "canonical_name": "viral capsid secondary envelopment", "definition": "The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope. [ISBN:0072370319, ISBN:0781718325, PMID:11533156]"}
{"concept_id": "C1160685", "aliases": ["viral capsid maturation", "capsid maturation"], "types": ["T038"], "canonical_name": "viral procapsid maturation", "definition": "The refolding and structural rearrangements of individual capsid subunits to transition from the intermediate procapsid, to the more stable capsid structure. [GOC:bf, PMID:10627558, PMID:19204733]"}
{"concept_id": "C1160686", "aliases": [], "types": ["T038"], "canonical_name": "viral scaffold assembly and maintenance", "definition": "The assembly and maintenance of the viral scaffold around which the viral capsid is constructed. [ISBN:0072370319]"}
{"concept_id": "C1160687", "aliases": [], "types": ["T043"], "canonical_name": "viral genome maturation", "definition": "The processes involved in creating a mature, stable viral genome. Begins after genome replication with a newly synthesized nucleic acid and ends when the genome is ready to be packaged. Includes the addition of proteins to the newly synthesized genome, and DNA repair processes. [GOC:pk, PMID:21490093]"}
{"concept_id": "C1160689", "aliases": [], "types": ["T045"], "definition": "The encapsulation of the viral genome within the capsid. [ISBN:0121585336]", "canonical_name": "viral genome packaging"}
{"concept_id": "C1160690", "aliases": [], "types": ["T043"], "canonical_name": "viral RNA genome packaging", "definition": "The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid. [ISBN:0781718325]"}
{"concept_id": "C1160691", "aliases": ["intracellular transport of viral material", "viral genome transport in host cell", "egress of virus within host cell", "intracellular transport of virus"], "types": ["T043"], "definition": "The directed movement of a virus, or part of a virus, within the host cell. [GOC:ai, GOC:bf, GOC:jl, PMID:11733033]", "canonical_name": "movement of virus within host cell"}
{"concept_id": "C1160692", "aliases": ["virus maturation"], "types": ["T043"], "definition": "The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release. [ISBN:0781718325]", "canonical_name": "viral maturation"}
{"concept_id": "C1160693", "aliases": ["viral exit", "viral release", "viral shedding", "viral release from host cell", "release of virus from host"], "types": ["T043"], "definition": "The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane. [GOC:jl]", "canonical_name": "virus exit from host cell"}
{"concept_id": "C1160697", "aliases": [], "types": ["T043"], "canonical_name": "non-lytic viral release", "definition": "The exit of a viral particle from a cell that does not involve cell lysis. [GOC:bf, GOC:jl, ISBN:0072370319]"}
{"concept_id": "C1160698", "aliases": [], "types": ["T043"], "canonical_name": "viral budding", "definition": "A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. [ISBN:0781718325, VZ:1947]"}
{"concept_id": "C1160699", "aliases": [], "types": ["T043"], "canonical_name": "viral exocytosis", "definition": "The exit of enveloped or unenveloped virion particles from the host cell by exocytosis, without causing cell lysis. [ISBN:0072370319]"}
{"concept_id": "C1160700", "aliases": ["viral genome expression"], "types": ["T043"], "canonical_name": "viral gene expression", "definition": "A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation. [GOC:bf, GOC:jl, ISBN:0121585336]"}
{"concept_id": "C1160701", "aliases": [], "types": ["T043"], "canonical_name": "viral genome replication", "definition": "Any process involved directly in viral genome replication, including viral nucleotide metabolism. [ISBN:0781702534]"}
{"concept_id": "C1160702", "aliases": [], "types": ["T038"], "canonical_name": "genome retention in viral capsid", "definition": "Any process in which the viral genome is retained within the capsid during genome cleavage and packaging. [PMID:9696839]"}
{"concept_id": "C1160703", "aliases": [], "types": ["T043"], "canonical_name": "regulation of viral genome replication", "definition": "Any process that modulates the frequency, rate or extent of viral genome replication. [GOC:ai]"}
{"concept_id": "C1160704", "aliases": ["downregulation of viral genome replication", "down regulation of viral genome replication", "down-regulation of viral genome replication"], "types": ["T045"], "canonical_name": "negative regulation of viral genome replication", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. [GOC:go_curators]"}
{"concept_id": "C1160705", "aliases": ["up regulation of viral genome replication", "upregulation of viral genome replication", "up-regulation of viral genome replication"], "types": ["T045"], "canonical_name": "positive regulation of viral genome replication", "definition": "Any process that activates or increases the frequency, rate or extent of viral genome replication. [GOC:ai]"}
{"concept_id": "C1160706", "aliases": ["viral ssRNA replication via dsDNA intermediate", "retroviral genome replication"], "types": ["T045"], "canonical_name": "single stranded viral RNA replication via double stranded DNA intermediate", "definition": "A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II. [GOC:bf, GOC:jl, ISBN:0198506732, VZ:1937]"}
{"concept_id": "C1160707", "aliases": ["regulation of single stranded viral RNA replication via double stranded DNA intermediate"], "types": ["T040"], "definition": "Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate. [GOC:go_curators]", "canonical_name": "regulation of retroviral genome replication"}
{"concept_id": "C1160708", "aliases": ["down regulation of retroviral genome replication", "down-regulation of retroviral genome replication", "downregulation of retroviral genome replication", "negative regulation of retroviral genome replication"], "types": ["T045"], "canonical_name": "negative regulation of single stranded viral RNA replication via double stranded DNA intermediate", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate. [GOC:go_curators]"}
{"concept_id": "C1160709", "aliases": ["upregulation of retroviral genome replication", "up regulation of retroviral genome replication", "up-regulation of retroviral genome replication", "positive regulation of retroviral genome replication"], "types": ["T045"], "canonical_name": "positive regulation of single stranded viral RNA replication via double stranded DNA intermediate", "definition": "Any process that activates or increases the frequency, rate or extent of retroviral genome replication. [GOC:go_curators]"}
{"concept_id": "C1160710", "aliases": [], "types": ["T043"], "canonical_name": "viral replication complex formation and maintenance", "definition": "The process of organizing and assembling viral replication proteins in preparation for viral replication. [ISBN:0781718325]"}
{"concept_id": "C1160712", "aliases": ["viral spread within host, cell to cell", "cell to cell spread of virus within host", "intercellular virus transport", "spread of virus in host, cell to cell", "spread of virus within host, cell to cell"], "types": ["T040"], "canonical_name": "transport of virus in host, cell to cell", "definition": "The transport of a virus between adjacent cells in a multicellular organism. [GOC:bf, GOC:jl, ISBN:0781718325]"}
{"concept_id": "C1160714", "aliases": ["immortalization of host cell", "host cell transformation", "viral transformation of host cell", "viral immortalization", "host cell immortalization", "transformation of host cell", "viral transformation"], "types": ["T043"], "canonical_name": "transformation of host cell by virus", "definition": "A virus-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication. [ISBN:0781702534, PMID:11119620, PMID:18366075, PMID:24373315]"}
{"concept_id": "C1160715", "aliases": [], "types": ["T043"], "canonical_name": "immortalization of host cell by virus"}
{"concept_id": "C1166607", "aliases": ["cellular component", "cell or subcellular entity"], "types": ["T026"], "canonical_name": "cellular_component", "definition": "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). [GOC:pdt, NIF_Subcellular:sao1337158144]"}
{"concept_id": "C1166608", "aliases": ["ascus lipid particle"], "types": ["T026"], "canonical_name": "ascus lipid droplet", "definition": "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins. [GOC:mah, PMID:12702293]"}
{"concept_id": "C1166609", "aliases": ["FSM", "forespore membrane", "prospore membrane"], "types": ["T026"], "definition": "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe. [ISBN:0879693649]", "canonical_name": "ascospore-type prospore membrane"}
{"concept_id": "C1166610", "aliases": ["fungal-type spore wall"], "types": ["T026"], "canonical_name": "ascospore wall", "definition": "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi. [GOC:vw, ISBN:0879693568]"}
{"concept_id": "C1166611", "aliases": [], "types": ["T026"], "canonical_name": "chitosan layer of spore wall", "definition": "The second outermost layer of the spore wall, as described in Saccharomyces. [ISBN:0879693568]"}
{"concept_id": "C1166612", "aliases": [], "types": ["T026"], "canonical_name": "dityrosine layer of spore wall", "definition": "The outermost layer of the spore wall, as described in Saccharomyces. [ISBN:0879693568]"}
{"concept_id": "C1166613", "aliases": [], "types": ["T026"], "canonical_name": "inner layer of spore wall", "definition": "Either of the two innermost layers of the spore wall, as described in Saccharomyces. [ISBN:0879693568]"}
{"concept_id": "C1166616", "aliases": ["cellular bud neck contractile ring"], "types": ["T026"], "definition": "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae. [GOC:krc, PMID:16009555]", "canonical_name": "neck ring"}
{"concept_id": "C1166617", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud neck septin ring", "definition": "A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange. [GOC:krc, PMID:16009555]"}
{"concept_id": "C1166618", "aliases": [], "types": ["T026"], "canonical_name": "polarisome", "definition": "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p. [PMID:14734532, PMID:14998522, PMID:9632790]"}
{"concept_id": "C1166629", "aliases": ["flagellin-based flagellum"], "types": ["T026"], "canonical_name": "bacterial-type flagellum", "definition": "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060]"}
{"concept_id": "C1166630", "aliases": ["flagellin-based flagellum basal body"], "types": ["T026"], "canonical_name": "bacterial-type flagellum basal body", "definition": "One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192, PMID:24697492]"}
{"concept_id": "C1166631", "aliases": ["flagellin-based flagellum basal body, C ring", "flagellar basal body, C ring"], "types": ["T026"], "canonical_name": "bacterial-type flagellum basal body, C ring", "definition": "Cytoplasmic ring located at the base of the bacterial-type flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]"}
{"concept_id": "C1166632", "aliases": ["flagellar basal body, distal rod", "flagellin-based flagellum basal body, distal rod"], "types": ["T026"], "canonical_name": "bacterial-type flagellum basal body, distal rod", "definition": "The portion of the central rod of the bacterial-type flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]"}
{"concept_id": "C1166633", "aliases": ["flagellin-based flagellum basal body, distal rod, L ring", "flagellar basal body, distal rod, L ring"], "types": ["T026"], "canonical_name": "bacterial-type flagellum basal body, distal rod, L ring", "definition": "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the outer membrane. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]"}
{"concept_id": "C1166634", "aliases": ["flagellin-based flagellum basal body, distal rod, P ring"], "types": ["T026"], "canonical_name": "bacterial-type flagellum basal body, distal rod, P ring", "definition": "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the peptidoglycan layer. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]"}
{"concept_id": "C1166636", "aliases": ["flagellin-based flagellum basal body, MS ring", "flagellar basal body, MS ring"], "types": ["T026"], "canonical_name": "bacterial-type flagellum basal body, MS ring", "definition": "One of the rings of the bacterial-type flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]"}
{"concept_id": "C1166637", "aliases": ["flagellin-based flagellum basal body, proximal rod", "flagellar basal body, proximal rod"], "types": ["T026"], "canonical_name": "bacterial-type flagellum basal body, proximal rod", "definition": "The portion of the central rod of the bacterial-type flagellar basal body that is proximal to the cell membrane; the proximal rod connects the distal rod to the flagellar motor. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]"}
{"concept_id": "C1166638", "aliases": ["flagellar filament", "flagellin-based flagellum filament"], "types": ["T026"], "canonical_name": "bacterial-type flagellum filament", "definition": "The long (approximately 20 nm), thin external structure of the bacterial-type flagellum, which acts as a propeller. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]"}
{"concept_id": "C1166639", "aliases": ["flagellar filament cap", "flagellin-based flagellum filament cap"], "types": ["T026"], "canonical_name": "bacterial-type flagellum filament cap", "definition": "The proteinaceous structure at the distal tip of the bacterial-type flagellar filament. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]"}
{"concept_id": "C1166640", "aliases": ["flagellin-based flagellum hook", "flagellar hook"], "types": ["T026"], "canonical_name": "bacterial-type flagellum hook", "definition": "The portion of the bacterial-type flagellum that connects the filament to the basal body. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192]"}
{"concept_id": "C1166641", "aliases": ["flagellar hook-filament junction"], "types": ["T026"], "canonical_name": "bacterial-type flagellum hook-filament junction", "definition": "The region of the bacterial-type flagellum where the hook and filament meet. [GOC:cilia, GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192]"}
{"concept_id": "C1166644", "aliases": ["cilium pocket membrane", "cilial pocket membrane", "flagellar pocket membrane"], "types": ["T026"], "canonical_name": "ciliary pocket membrane", "definition": "That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket). [GOC:cilia, GOC:mb]"}
{"concept_id": "C1166645", "aliases": ["cilium pocket", "flagellar pocket", "cilial pocket"], "types": ["T026"], "canonical_name": "ciliary pocket", "definition": "Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes. [GOC:cilia, GOC:mb]"}
{"concept_id": "C1166646", "aliases": ["apical part of cell"], "types": ["T026"], "definition": "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. [GOC:mah, ISBN:0815316194]", "canonical_name": "apical region of cell"}
{"concept_id": "C1166647", "aliases": ["apical complex location"], "types": ["T026"], "canonical_name": "apical complex", "definition": "A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation. [GOC:giardia, GOC:mb, PMID:16518471]"}
{"concept_id": "C1166648", "aliases": ["lower polar ring of apical complex", "preconoidal ring of apical complex", "lower polar ring of apical complex location", "posterior polar ring of apical complex", "posterior polar ring of apical complex location", "preconoidal ring of apical complex location", "basal ring of apical complex location"], "types": ["T026"], "canonical_name": "basal ring of apical complex", "definition": "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite. [GOC:mah, PMID:16518471]"}
{"concept_id": "C1166649", "aliases": [], "types": ["T026"], "definition": "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules. [GOC:expert_dr, PMID:11901169, PMID:16518471]", "canonical_name": "conoid"}
{"concept_id": "C1166650", "aliases": ["sarconeme"], "types": ["T026"], "definition": "A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell. [ISBN:0521664470, PMID:11801218]", "canonical_name": "microneme"}
{"concept_id": "C1166651", "aliases": ["upper polar ring of apical complex", "anterior polar ring of apical complex location", "upper polar ring of apical complex location", "anterior polar ring of apical complex", "polar ring of apical complex location"], "types": ["T026"], "canonical_name": "polar ring of apical complex", "definition": "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite. [GOC:mb, PMID:16518471]"}
{"concept_id": "C1166652", "aliases": [], "types": ["T026"], "canonical_name": "rhoptry", "definition": "A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole. [ISBN:0521664470, PMID:11801218, PMID:16002398]"}
{"concept_id": "C1166653", "aliases": [], "types": ["T026"], "canonical_name": "subpellicular microtubule", "definition": "Singlet microtubule that lie underneath the inner membrane pellicle complex and emanate from the basal ring of the conoid. [GOC:mb, PMID:24800253]"}
{"concept_id": "C1166654", "aliases": [], "types": ["T026"], "canonical_name": "apical cortex", "definition": "The region that lies just beneath the plasma membrane on the apical edge of a cell. [GOC:bf]"}
{"concept_id": "C1166656", "aliases": [], "types": ["T026"], "canonical_name": "basal cortex", "definition": "The region that lies just beneath the plasma membrane on the basal edge of a cell. [GOC:bf]"}
{"concept_id": "C1166657", "aliases": [], "types": ["T026"], "canonical_name": "cell cortex", "definition": "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1166658", "aliases": [], "types": ["T026"], "canonical_name": "actin cap", "definition": "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae. [GOC:mah, PMID:21494665]"}
{"concept_id": "C1166660", "aliases": ["actin patch"], "types": ["T026"], "canonical_name": "actin cortical patch", "definition": "An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae. [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963]"}
{"concept_id": "C1166662", "aliases": ["nematocyst"], "types": ["T026"], "definition": "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. [DOI:10.1139/z02-135, GOC:jl]", "canonical_name": "cnidocyst"}
{"concept_id": "C1166663", "aliases": ["actomyosin contractile ring", "actomyosin ring", "CAR", "constriction ring"], "types": ["T026"], "definition": "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis. [GOC:expert_jrp, GOC:sgd_curators, GOC:vw, ISBN:0805319409, ISBN:0815316194, PMID:28914606]", "canonical_name": "contractile actomyosin ring"}
{"concept_id": "C1166666", "aliases": ["exocyst complex location", "exocyst complex", "Sec6/8 complex", "Sec6/8 complex location"], "types": ["T026"], "canonical_name": "exocyst", "definition": "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]"}
{"concept_id": "C1166667", "aliases": [], "types": ["T026"], "canonical_name": "septin ring", "definition": "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244]"}
{"concept_id": "C1166668", "aliases": [], "types": ["T026"], "definition": "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. [GOC:curators, ISBN:0815316194]", "canonical_name": "spectrin"}
{"concept_id": "C1166669", "aliases": ["transcriptionally active chromatin"], "types": ["T026"], "definition": "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. [PMID:32017156]", "canonical_name": "euchromatin"}
{"concept_id": "C1166670", "aliases": ["pericentric heterochromatin", "centric heterochromatin"], "types": ["T026"], "definition": "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). [PMID:12019236, PMID:20206496, PMID:22729156, PMID:9413993]", "canonical_name": "centromeric heterochromatin"}
{"concept_id": "C1166671", "aliases": [], "types": ["T026"], "definition": "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization. [PMID:8878678]", "canonical_name": "alpha-heterochromatin"}
{"concept_id": "C1166672", "aliases": [], "types": ["T026"], "definition": "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization. [PMID:11404334, PMID:8878678]", "canonical_name": "beta-heterochromatin"}
{"concept_id": "C1166673", "aliases": [], "types": ["T026"], "canonical_name": "intercalary heterochromatin", "definition": "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes. [PMID:14579245]"}
{"concept_id": "C1166675", "aliases": [], "types": ["T026"], "definition": "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:elh]", "canonical_name": "nucleosome"}
{"concept_id": "C1166676", "aliases": [], "types": ["T026"], "canonical_name": "perichromatin fibrils", "definition": "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts. [PMID:14731598]"}
{"concept_id": "C1166679", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A chromosome found in the cytoplasm during mitosis. [GOC:mah]", "canonical_name": "cytoplasmic mitotic chromosome"}
{"concept_id": "C1166680", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently. [GOC:ai, ISBN:0815316194]", "canonical_name": "interphase chromosome"}
{"concept_id": "C1166681", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A chromosome found in the nucleus during interphase. [GOC:mah]", "canonical_name": "nuclear interphase chromosome"}
{"concept_id": "C1166682", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A chromosome involved in the process of meiosis. [GOC:ai]", "canonical_name": "meiotic chromosome"}
{"concept_id": "C1166683", "aliases": [], "types": ["T026"], "canonical_name": "recombination nodule", "definition": "An electron dense structure that is associated with meiotic chromosomes. [GOC:elh]"}
{"concept_id": "C1166684", "aliases": [], "types": ["T026"], "canonical_name": "early recombination nodule", "definition": "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I. [GOC:elh]"}
{"concept_id": "C1166685", "aliases": [], "types": ["T026"], "canonical_name": "late recombination nodule", "definition": "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I. [GOC:elh]"}
{"concept_id": "C1166687", "aliases": [], "types": ["T026"], "definition": "A chromosome found in the mitochondrion of a eukaryotic cell. [GOC:mah]", "canonical_name": "mitochondrial chromosome"}
{"concept_id": "C1166688", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A chromosome involved in the process of mitosis. [GOC:ai]", "canonical_name": "mitotic chromosome"}
{"concept_id": "C1166689", "aliases": ["SMC/kleisin ring complex", "SMC/kleisin ring complex location", "cohesin complex location"], "types": ["T026"], "canonical_name": "cohesin complex", "definition": "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). [GOC:jl, GOC:sp, GOC:vw, PMID:9887095]"}
{"concept_id": "C1166690", "aliases": [], "types": ["T026"], "canonical_name": "cohesin core heterodimer"}
{"concept_id": "C1166693", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins. [GOC:ai]", "canonical_name": "metaphase chromosome"}
{"concept_id": "C1166694", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A chromosome found in the nucleus during mitosis. [GOC:mah]", "canonical_name": "nuclear mitotic chromosome"}
{"concept_id": "C1166695", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A chromosome found in the cell during prophase. [GOC:ai]", "canonical_name": "prophase chromosome"}
{"concept_id": "C1166696", "aliases": [], "types": ["T026"], "definition": "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. [GOC:dph, GOC:mah]", "canonical_name": "nuclear chromosome"}
{"concept_id": "C1166697", "aliases": [], "types": ["T026"], "canonical_name": "plastid chromosome", "definition": "A circular DNA molecule containing plastid encoded genes. [ISBN:0943088399]"}
{"concept_id": "C1166698", "aliases": [], "types": ["T026"], "definition": "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible. [ISBN:0198506732]", "canonical_name": "polytene chromosome"}
{"concept_id": "C1166699", "aliases": [], "types": ["T026"], "canonical_name": "polytene chromosome band", "definition": "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band. [GOC:bf, PMID:11361342]"}
{"concept_id": "C1166700", "aliases": ["polytene chromosome chromocentre"], "types": ["T026"], "canonical_name": "polytene chromosome chromocenter", "definition": "A region at which the centric regions of polytene chromosomes are joined together. [GOC:bf, ISBN:0120649012]"}
{"concept_id": "C1166701", "aliases": ["polytene chromosome ectopic fibre"], "types": ["T026"], "canonical_name": "polytene chromosome ectopic fiber", "definition": "A thread-like connection joining two regions of ectopically paired polytene chromosomes. [GOC:bf, ISBN:0120649012]"}
{"concept_id": "C1166702", "aliases": [], "types": ["T026"], "canonical_name": "polytene chromosome interband", "definition": "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands. [GOC:bf, PMID:11361342]"}
{"concept_id": "C1166703", "aliases": [], "types": ["T026"], "canonical_name": "polytene chromosome puff", "definition": "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription. [GOC:bf, ISBN:0120649012]"}
{"concept_id": "C1166704", "aliases": [], "types": ["T026"], "definition": "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization. [GOC:bf, ISBN:0120649012]", "canonical_name": "polytene chromosome weak point"}
{"concept_id": "C1166705", "aliases": ["telomerase holoenzyme complex location"], "types": ["T026"], "canonical_name": "telomerase holoenzyme complex", "definition": "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. [PMID:11884619]"}
{"concept_id": "C1166706", "aliases": ["telomerase catalytic core complex location"], "types": ["T026"], "canonical_name": "telomerase catalytic core complex", "definition": "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. [GOC:BHF-UCL, PMID:11884619, PMID:1808260]"}
{"concept_id": "C1166708", "aliases": ["axonemal dynein complex location"], "types": ["T026"], "canonical_name": "axonemal dynein complex", "definition": "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]"}
{"concept_id": "C1166710", "aliases": ["outer dense fibre"], "types": ["T026"], "canonical_name": "outer dense fiber", "definition": "A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins. [GOC:cilia, GOC:krc, ISBN:0824072820, PMID:10381817, PMID:21586547, PMID:25361759]"}
{"concept_id": "C1166712", "aliases": [], "types": ["T026"], "canonical_name": "radial spoke stalk", "definition": "Globular portion of the radial spoke that projects towards the central pair of microtubules. [GOC:hjd]"}
{"concept_id": "C1166713", "aliases": ["radial spokehead"], "types": ["T026"], "canonical_name": "radial spoke head", "definition": "Protein complex forming part of eukaryotic flagellar apparatus. [GOC:cilia, GOC:hjd, GOC:krc]"}
{"concept_id": "C1166714", "aliases": ["CDK holoenzyme", "cyclin-dependent protein kinase holoenzyme complex"], "types": ["T026"], "definition": "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. [GOC:krc, PMID:11602261]", "canonical_name": "cyclin-dependent protein kinase holoenzyme complex location"}
{"concept_id": "C1166715", "aliases": ["cytoplasmic cyclin-dependent protein kinase holoenzyme complex location"], "types": ["T026"], "definition": "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm. [GOC:krc]", "canonical_name": "cytoplasmic cyclin-dependent protein kinase holoenzyme complex"}
{"concept_id": "C1166716", "aliases": ["nuclear cyclin-dependent protein kinase holoenzyme complex"], "types": ["T026"], "definition": "Cyclin-dependent protein kinase (CDK) complex found in the nucleus. [GOC:krc]", "canonical_name": "nuclear cyclin-dependent protein kinase holoenzyme complex location"}
{"concept_id": "C1166718", "aliases": [], "types": ["T026"], "definition": "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells. [ISBN:0198547684]", "canonical_name": "cell plate"}
{"concept_id": "C1166719", "aliases": ["cytoplasmic exosome (ribonuclease complex)", "cytoplasmic exosome (ribonuclease complex location)", "prokaryotic exosome multienzyme ribonuclease complex location", "cytoplasmic exosome multienzyme ribonuclease complex location", "prokaryotic exosome multienzyme ribonuclease complex", "cytoplasmic exosome (RNase complex location)", "cytoplasmic exosome multienzyme ribonuclease complex"], "types": ["T026"], "canonical_name": "cytoplasmic exosome (RNase complex)", "definition": "A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. [PMID:17174896, PMID:20531386, PMID:26726035]"}
{"concept_id": "C1166720", "aliases": ["cytoplasmic ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "cytoplasmic ubiquitin ligase complex", "definition": "A ubiquitin ligase complex found in the cytoplasm. [GOC:mah]"}
{"concept_id": "C1166721", "aliases": ["SCF complex location", "CDL1 complex location", "CRL1 complex", "Skp1/Cul1/F-box protein complex location", "cullin-RING ligase 1", "SCF ubiquitin ligase complex location", "CRL1 complex location", "Cul1-RING ubiquitin ligase complex", "Cul1-RING ubiquitin ligase complex location", "CDL1 complex", "Skp1/Cul1/F-box protein complex", "SCF complex"], "types": ["T026"], "canonical_name": "SCF ubiquitin ligase complex", "definition": "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1166722", "aliases": [], "types": ["T026"], "canonical_name": "chitosome", "definition": "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum. [ISBN:0198506732, PMID:8970154]"}
{"concept_id": "C1166723", "aliases": [], "types": ["T026"], "canonical_name": "chitosome membrane", "definition": "The lipid bilayer surrounding a chitosome. [GOC:mah]"}
{"concept_id": "C1166724", "aliases": ["clathrin coated vesicle membrane"], "types": ["T026"], "canonical_name": "clathrin-coated vesicle membrane", "definition": "The lipid bilayer surrounding a clathrin-coated vesicle. [GOC:mah]"}
{"concept_id": "C1166725", "aliases": [], "types": ["T026"], "canonical_name": "clathrin-coated endocytic vesicle membrane", "definition": "The lipid bilayer surrounding a clathrin-coated endocytic vesicle. [GOC:mah]"}
{"concept_id": "C1166726", "aliases": [], "types": ["T026"], "canonical_name": "clathrin-coated phagocytic vesicle membrane", "definition": "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle. [GOC:mah]"}
{"concept_id": "C1166727", "aliases": ["trans-Golgi network constitutive secretory pathway transport vesicle membrane", "TGN transport vesicle membrane"], "types": ["T026"], "canonical_name": "trans-Golgi network transport vesicle membrane", "definition": "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. [GOC:ai]"}
{"concept_id": "C1166728", "aliases": [], "types": ["T026"], "canonical_name": "clathrin vesicle coat", "definition": "A clathrin coat found on a vesicle. [GOC:mah]"}
{"concept_id": "C1166729", "aliases": ["clathrin coat of endocytotic vesicle"], "types": ["T026"], "canonical_name": "clathrin coat of endocytic vesicle", "definition": "A clathrin coat found on an endocytic vesicle. [GOC:mah]"}
{"concept_id": "C1166730", "aliases": ["AP-2 adaptor complex", "HA2", "AP-2 adaptor complex location"], "types": ["T026"], "definition": "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426]", "canonical_name": "HA2 clathrin adaptor"}
{"concept_id": "C1166731", "aliases": [], "types": ["T026"], "canonical_name": "clathrin coat of synaptic vesicle", "definition": "A clathrin coat found on a synaptic vesicle. [GOC:mah]"}
{"concept_id": "C1166732", "aliases": ["clathrin coat of TGN vesicle"], "types": ["T026"], "canonical_name": "clathrin coat of trans-Golgi network vesicle", "definition": "A clathrin coat found on a vesicle of the trans-Golgi network. [GOC:mah]"}
{"concept_id": "C1166734", "aliases": [], "types": ["T026"], "canonical_name": "clathrin-coated endocytic vesicle", "definition": "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. [GOC:go_curators]"}
{"concept_id": "C1166735", "aliases": ["clathrin-coated phagosome"], "types": ["T026"], "canonical_name": "clathrin-coated phagocytic vesicle", "definition": "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1166736", "aliases": [], "types": ["T026"], "canonical_name": "synaptic vesicle membrane", "definition": "The lipid bilayer surrounding a synaptic vesicle. [GOC:mah]"}
{"concept_id": "C1166737", "aliases": ["integral to synaptic vesicle membrane"], "types": ["T026"], "canonical_name": "integral component of synaptic vesicle membrane", "definition": "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:go_curators]"}
{"concept_id": "C1166738", "aliases": ["trans-Golgi network constitutive secretory pathway transport vesicle", "TGN transport vesicle"], "types": ["T026"], "canonical_name": "trans-Golgi network transport vesicle", "definition": "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. [GOC:mah]"}
{"concept_id": "C1166739", "aliases": [], "types": ["T026"], "canonical_name": "coated vesicle membrane", "definition": "The lipid bilayer surrounding a coated vesicle. [GOC:mah]"}
{"concept_id": "C1166740", "aliases": ["COPI coated vesicle membrane"], "types": ["T026"], "canonical_name": "COPI-coated vesicle membrane", "definition": "The lipid bilayer surrounding a COPI-coated vesicle. [GOC:mah]"}
{"concept_id": "C1166741", "aliases": ["Golgi-ER transport vesicle membrane", "Golgi to ER constitutive secretory pathway transport vesicle membrane", "Golgi-endoplasmic reticulum transport vesicle membrane", "Golgi to endoplasmic reticulum transport vesicle membrane"], "types": ["T026"], "canonical_name": "Golgi to ER transport vesicle membrane", "definition": "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER. [GOC:ai]"}
{"concept_id": "C1166742", "aliases": ["inter-Golgi transport constitutive secretory pathway transport vesicle membrane"], "types": ["T026"], "canonical_name": "inter-Golgi transport vesicle membrane", "definition": "The lipid bilayer surrounding a vesicle transporting substances within the Golgi. [GOC:ai]"}
{"concept_id": "C1166744", "aliases": ["COPII coated vesicle membrane", "ER to Golgi constitutive secretory pathway transport vesicle membrane", "endoplasmic reticulum to Golgi transport vesicle membrane", "ER-Golgi transport vesicle membrane", "endoplasmic reticulum-Golgi transport vesicle membrane"], "types": ["T026"], "canonical_name": "ER to Golgi transport vesicle membrane", "definition": "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C1166745", "aliases": ["retrograde transport vesicle", "Golgi to ER constitutive secretory pathway transport vesicle", "Golgi-ER transport vesicle", "Golgi-endoplasmic reticulum transport vesicle", "Golgi to endoplasmic reticulum transport vesicle"], "types": ["T026"], "canonical_name": "COPI-coated Golgi to ER transport vesicle", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1166746", "aliases": ["inter-Golgi transport constitutive secretory pathway transport vesicle"], "types": ["T026"], "canonical_name": "COPI-coated inter-Golgi transport vesicle", "definition": "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack). [GOC:mah]"}
{"concept_id": "C1166747", "aliases": [], "types": ["T026"], "definition": "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]", "canonical_name": "COPII vesicle coat"}
{"concept_id": "C1166748", "aliases": [], "types": ["T026"], "canonical_name": "COPII vesicle", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1166749", "aliases": [], "types": ["T026"], "canonical_name": "vesicle coat", "definition": "A membrane coat found on a coated vesicle. [GOC:mah]"}
{"concept_id": "C1166750", "aliases": [], "types": ["T026"], "definition": "The lipid bilayer surrounding a cytoplasmic vesicle. [GOC:mah]", "canonical_name": "cytoplasmic vesicle membrane"}
{"concept_id": "C1166752", "aliases": ["phagosome membrane"], "types": ["T026"], "canonical_name": "phagocytic vesicle membrane", "definition": "The lipid bilayer surrounding a phagocytic vesicle. [GOC:mah]"}
{"concept_id": "C1166753", "aliases": [], "types": ["T026"], "canonical_name": "Golgi vesicle membrane"}
{"concept_id": "C1166754", "aliases": [], "types": ["T026"], "definition": "The lipid bilayer surrounding a secretory granule. [GOC:mah]", "canonical_name": "secretory granule membrane"}
{"concept_id": "C1166756", "aliases": ["constitutive secretory pathway transport vesicle membrane"], "types": ["T026"], "definition": "The lipid bilayer surrounding a transport vesicle. [GOC:mah]", "canonical_name": "transport vesicle membrane"}
{"concept_id": "C1166757", "aliases": ["dense body"], "types": ["T026"], "definition": "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell. [GOC:mb, GOC:mtg_sensu]", "canonical_name": "merozoite dense granule"}
{"concept_id": "C1166762", "aliases": ["actin capping protein of dynactin complex location"], "types": ["T026"], "canonical_name": "actin capping protein of dynactin complex", "definition": "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex. [GOC:jl, PMID:18221362, PMID:18544499]"}
{"concept_id": "C1166763", "aliases": ["Arp2/3 protein complex location"], "types": ["T026"], "canonical_name": "Arp2/3 protein complex", "definition": "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. [GOC:jl, GOC:vw, PMID:12479800]"}
{"concept_id": "C1166764", "aliases": ["cytoplasmic dynein complex location"], "types": ["T026"], "canonical_name": "cytoplasmic dynein complex", "definition": "Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]"}
{"concept_id": "C1166769", "aliases": [], "types": ["T026"], "canonical_name": "non-muscle myosin"}
{"concept_id": "C1166774", "aliases": [], "types": ["T026"], "canonical_name": "muscle thin filament tropomyosin", "definition": "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments. [ISBN:0815316194]"}
{"concept_id": "C1166775", "aliases": ["troponin complex"], "types": ["T026"], "definition": "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction. [ISBN:0815316194]", "canonical_name": "troponin complex location"}
{"concept_id": "C1166776", "aliases": [], "types": ["T026"], "canonical_name": "cornified envelope", "definition": "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139]"}
{"concept_id": "C1166777", "aliases": [], "types": ["T026"], "definition": "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. [ISBN:0716731363]", "canonical_name": "intermediate filament cytoskeleton"}
{"concept_id": "C1166778", "aliases": [], "types": ["T026"], "definition": "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. [ISBN:0716731363]", "canonical_name": "keratin filament"}
{"concept_id": "C1166781", "aliases": [], "types": ["T026"], "definition": "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172]", "canonical_name": "microtubule cytoskeleton"}
{"concept_id": "C1166782", "aliases": [], "types": ["T026"], "canonical_name": "nuclear microtubule", "definition": "Any microtubule in the nucleus of a cell. [GOC:mah]"}
{"concept_id": "C1166783", "aliases": [], "types": ["T026"], "definition": "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. [ISBN:0815316194]", "canonical_name": "spindle microtubule"}
{"concept_id": "C1166784", "aliases": [], "types": ["T026"], "canonical_name": "astral microtubule", "definition": "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. [ISBN:0815316194]"}
{"concept_id": "C1166785", "aliases": ["pole-to-kinetochore microtubule"], "types": ["T026"], "canonical_name": "kinetochore microtubule", "definition": "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. [ISBN:0815316194]"}
{"concept_id": "C1166786", "aliases": ["pole-to-pole microtubule"], "types": ["T026"], "canonical_name": "polar microtubule", "definition": "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart. [ISBN:0815316194]"}
{"concept_id": "C1166788", "aliases": ["microtubule associated complex location"], "types": ["T026"], "canonical_name": "microtubule associated complex", "definition": "Any multimeric complex connected to a microtubule. [GOC:jl]"}
{"concept_id": "C1166789", "aliases": ["dynein complex location"], "types": ["T026"], "definition": "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. [ISBN:0815316194]", "canonical_name": "dynein complex"}
{"concept_id": "C1166790", "aliases": ["kinesin complex location"], "types": ["T026"], "canonical_name": "kinesin complex", "definition": "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]"}
{"concept_id": "C1166791", "aliases": ["kinesin I complex location"], "types": ["T026"], "canonical_name": "kinesin I complex", "definition": "A complex of two kinesin heavy chains and two kinesin light chains. [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]"}
{"concept_id": "C1166792", "aliases": ["kinesin II complex location"], "types": ["T026"], "canonical_name": "kinesin II complex", "definition": "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes. [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]"}
{"concept_id": "C1166793", "aliases": ["minus-end kinesin complex location"], "types": ["T026"], "canonical_name": "minus-end kinesin complex", "definition": "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule. [GOC:mah]"}
{"concept_id": "C1166794", "aliases": ["plus-end kinesin complex location"], "types": ["T026"], "canonical_name": "plus-end kinesin complex", "definition": "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule. [GOC:mah]"}
{"concept_id": "C1166795", "aliases": [], "types": ["T026"], "definition": "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. [ISBN:0198547684]", "canonical_name": "spindle"}
{"concept_id": "C1166797", "aliases": [], "types": ["T026"], "canonical_name": "central plaque of spindle pole body", "definition": "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope. [ISBN:0879693568]"}
{"concept_id": "C1166798", "aliases": [], "types": ["T026"], "canonical_name": "half bridge of spindle pole body", "definition": "Structure adjacent to the plaques of the spindle pole body. [ISBN:0879693568]"}
{"concept_id": "C1166799", "aliases": [], "types": ["T026"], "canonical_name": "inner plaque of spindle pole body", "definition": "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus. [ISBN:0879693568]"}
{"concept_id": "C1166800", "aliases": [], "types": ["T026"], "canonical_name": "intermediate layer of spindle pole body", "definition": "Structure between the central and outer plaques of the spindle pole body. [PMID:9215630]"}
{"concept_id": "C1166801", "aliases": [], "types": ["T026"], "canonical_name": "outer plaque of spindle pole body", "definition": "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm. [ISBN:0879693568]"}
{"concept_id": "C1166802", "aliases": [], "types": ["T026"], "canonical_name": "subpellicular network", "definition": "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton. [PMID:11420112]"}
{"concept_id": "C1166803", "aliases": ["1-phosphatidylinositol 3-kinase complex", "phosphatidylinositol 3-kinase complex location", "PI3K complex location", "phosphoinositide 3-kinase complex", "phosphoinositide 3-kinase complex location", "PI3K complex", "1-phosphatidylinositol 3-kinase complex location"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex", "definition": "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. [GOC:bf, PMID:24587488]"}
{"concept_id": "C1166804", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin group. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome. [PMID:10410804]", "canonical_name": "26S proteasome"}
{"concept_id": "C1166808", "aliases": ["proteasome core complex location", "20S proteasome", "proteasome core complex"], "types": ["T026"], "definition": "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. [GOC:rb, PMID:10806206]", "canonical_name": "macropain"}
{"concept_id": "C1166811", "aliases": ["proteasome activator complex", "PA28"], "types": ["T026"], "definition": "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex. [GOC:rb]", "canonical_name": "proteasome activator complex location"}
{"concept_id": "C1166812", "aliases": ["6-phosphofructokinase complex location"], "types": ["T026"], "canonical_name": "6-phosphofructokinase complex", "definition": "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. [GOC:mah, GOC:vw, ISBN:0198506732]"}
{"concept_id": "C1166813", "aliases": ["chaperonin ATPase complex location"], "types": ["T026"], "canonical_name": "chaperonin ATPase complex", "definition": "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts. [EC:3.6.4.9]"}
{"concept_id": "C1166814", "aliases": ["chaperonin-containing T-complex", "TriC", "chaperonin-containing T-complex location"], "types": ["T026"], "definition": "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor. [GOC:sgd_curators, PMID:11580267]", "canonical_name": "CCT particle"}
{"concept_id": "C1166815", "aliases": [], "types": ["T026"], "canonical_name": "70S ribosome"}
{"concept_id": "C1166821", "aliases": ["cytosolic FAS complex location", "cytosolic fatty acid synthase complex", "cytosolic type I fatty acid synthase complex location", "FAS complex", "fatty acid synthase complex", "cytosolic fatty acid synthase complex location", "fatty acid synthetase complex location", "FAS complex location", "cytosolic type I FAS complex", "cytosolic type I FAS complex location", "fatty acid synthase complex location", "fatty acid synthetase complex", "cytosolic type I fatty acid synthase complex"], "types": ["T026"], "definition": "A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. [GOC:pde, GOC:sgd_curators, ISBN:0716746840]", "canonical_name": "cytosolic FAS complex"}
{"concept_id": "C1166822", "aliases": ["fatty acid elongase complex location"], "types": ["T026"], "canonical_name": "fatty acid elongase complex", "definition": "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids. [GOC:tb]"}
{"concept_id": "C1166823", "aliases": ["fatty acyl CoA synthase complex", "fatty-acyl-CoA synthase complex location", "fatty acyl CoA synthase complex location"], "types": ["T026"], "canonical_name": "fatty-acyl-CoA synthase complex", "definition": "A protein complex that possesses fatty-acyl-CoA synthase activity. [BRENDA:2.3.1.86, GOC:mah]"}
{"concept_id": "C1166824", "aliases": ["haemoglobin complex location", "haemoglobin complex", "hemoglobin complex location"], "types": ["T026"], "canonical_name": "hemoglobin complex", "definition": "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1166825", "aliases": ["trimeric IKK complex", "IkappaB kinase complex", "IKK complex", "trimeric IKK complex location", "IKK complex location", "IkappaB kinase complex location", "heterotrimeric IKK complex"], "types": ["T026"], "definition": "A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. [GOC:bf, GOC:ma, PMID:12055104, PMID:20300203]", "canonical_name": "heterotrimeric IKK complex location"}
{"concept_id": "C1166826", "aliases": ["phosphopyruvate hydratase complex location", "enolase complex location", "enolase complex"], "types": ["T026"], "canonical_name": "phosphopyruvate hydratase complex", "definition": "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1166827", "aliases": ["prefoldin complex location"], "types": ["T026"], "canonical_name": "prefoldin complex", "definition": "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics. [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]"}
{"concept_id": "C1166828", "aliases": ["steroid hormone aporeceptor complex location"], "types": ["T026"], "canonical_name": "steroid hormone aporeceptor complex", "definition": "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand. [PMID:7493981]"}
{"concept_id": "C1166829", "aliases": ["dystrophin-associated glycoprotein complex location", "DGC", "dystrophin glycoprotein complex location", "dystrophin glycoprotein complex"], "types": ["T026"], "canonical_name": "dystrophin-associated glycoprotein complex", "definition": "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase. [PMID:15117830, PMID:16710609]"}
{"concept_id": "C1166830", "aliases": ["dystrobrevin complex location"], "types": ["T026"], "canonical_name": "dystrobrevin complex", "definition": "A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex. [PMID:15117830, PMID:16710609]"}
{"concept_id": "C1166831", "aliases": ["dystroglycan complex location"], "types": ["T026"], "canonical_name": "dystroglycan complex", "definition": "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin. [PMID:15117830, PMID:16710609]"}
{"concept_id": "C1166833", "aliases": ["sarcoglycan complex location", "sarcoglycan complex", "sarcoglycan-sarcospan complex location"], "types": ["T026"], "definition": "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex. [PMID:15117830, PMID:16710609]", "canonical_name": "sarcoglycan-sarcospan complex"}
{"concept_id": "C1166834", "aliases": ["syntrophin complex location"], "types": ["T026"], "canonical_name": "syntrophin complex", "definition": "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase. [http://www.dmd.nl/DGC.html#syn]"}
{"concept_id": "C1166835", "aliases": ["cytosolic electron transfer flavoprotein complex location"], "types": ["T026"], "canonical_name": "cytosolic electron transfer flavoprotein complex", "definition": "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors. [GOC:mtg_sensu, ISBN:0198506732]"}
{"concept_id": "C1166837", "aliases": ["endoplasmic reticulum lumen", "ER lumen", "cisternal lumen", "ER cisterna"], "types": ["T026"], "definition": "The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]", "canonical_name": "endoplasmic reticulum cisterna"}
{"concept_id": "C1166839", "aliases": ["integral to endoplasmic reticulum membrane", "integral to ER membrane", "ER integral membrane protein"], "types": ["T026"], "canonical_name": "integral component of endoplasmic reticulum membrane", "definition": "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1166840", "aliases": ["oligosaccharyltransferase complex location", "OST complex", "oligosaccharyl transferase complex location", "oligosaccharyl transferase complex", "OST complex location"], "types": ["T026"], "canonical_name": "oligosaccharyltransferase complex", "definition": "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected. [ISBN:0879695595, PMID:15835887]"}
{"concept_id": "C1166841", "aliases": ["serine C-palmitoyltransferase complex location"], "types": ["T026"], "canonical_name": "serine C-palmitoyltransferase complex", "definition": "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine. [EC:2.3.1.50]"}
{"concept_id": "C1166842", "aliases": ["plasmodesmatal ER"], "types": ["T026"], "canonical_name": "plasmodesmatal endoplasmic reticulum", "definition": "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells. [GOC:ai, PMID:29880547]"}
{"concept_id": "C1166844", "aliases": ["docking protein complex location"], "types": ["T026"], "canonical_name": "docking protein complex"}
{"concept_id": "C1166845", "aliases": ["signal peptidase complex location"], "types": ["T026"], "canonical_name": "signal peptidase complex", "definition": "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. [GOC:sgd_curators, PMID:1846444, PMID:7615509]"}
{"concept_id": "C1166846", "aliases": ["SRP", "signal sequence receptor complex location", "signal recognition particle, endoplasmic reticulum targeting"], "types": ["T026"], "definition": "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. [GOC:mtg_sensu, ISBN:0198506732]", "canonical_name": "signal sequence receptor complex"}
{"concept_id": "C1166848", "aliases": ["prevacuolar compartment", "late endosome"], "types": ["T026"], "definition": "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]", "canonical_name": "PVC"}
{"concept_id": "C1166850", "aliases": ["eukaryotic 43S pre-initiation complex", "eukaryotic 43S preinitiation complex location", "eukaryotic 43S pre-initiation complex location"], "types": ["T026"], "canonical_name": "eukaryotic 43S preinitiation complex", "definition": "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA. [GOC:hjd, PMID:15145049]"}
{"concept_id": "C1166851", "aliases": ["eukaryotic translation initiation factor 2 complex location", "eIF2", "eukaryotic translation initiation factor 2 complex"], "types": ["T026"], "definition": "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. [PMID:10216940]", "canonical_name": "eIF-2"}
{"concept_id": "C1166852", "aliases": ["eukaryotic translation initiation factor 3 complex location", "eIF3", "eukaryotic translation initiation factor 3 complex"], "types": ["T026"], "definition": "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. [PMID:15904532]", "canonical_name": "eIF-3"}
{"concept_id": "C1166854", "aliases": ["eukaryotic translation elongation factor 1 complex location"], "types": ["T026"], "canonical_name": "eukaryotic translation elongation factor 1 complex", "definition": "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. [GOC:jl, PMID:10216950]"}
{"concept_id": "C1166855", "aliases": ["eIF-2B", "eukaryotic translation initiation factor 2B complex location", "eukaryotic translation initiation factor 2B complex"], "types": ["T026"], "definition": "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. [PMID:9438375]", "canonical_name": "eif2B"}
{"concept_id": "C1166856", "aliases": ["eIF-4F", "eukaryotic translation initiation factor 4F complex location"], "types": ["T026"], "definition": "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. [GOC:hb, PMID:8449919]", "canonical_name": "eukaryotic translation initiation factor 4F complex"}
{"concept_id": "C1166857", "aliases": [], "types": ["T026"], "canonical_name": "fusome", "definition": "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle. [GOC:bf, PMID:12655376]"}
{"concept_id": "C1166858", "aliases": ["Golgi cis-face", "forming face"], "types": ["T026"], "canonical_name": "Golgi cis face"}
{"concept_id": "C1166859", "aliases": ["TRAPP1", "TRAPP complex", "transport protein particle complex", "TRAPP2", "TRAPP complex location", "transport protein particle complex location"], "types": ["T026"], "definition": "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active. [GOC:bhm, GOC:vw, PMID:22669257]", "canonical_name": "transport protein particle"}
{"concept_id": "C1166860", "aliases": [], "types": ["T026"], "canonical_name": "Golgi lumen", "definition": "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. [GOC:mah]"}
{"concept_id": "C1166861", "aliases": ["Golgi integral membrane protein", "integral to Golgi membrane"], "types": ["T026"], "canonical_name": "integral component of Golgi membrane", "definition": "The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:go_curators]"}
{"concept_id": "C1166863", "aliases": [], "types": ["T026"], "canonical_name": "Golgi cis cisterna", "definition": "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. [ISBN:0815316194]"}
{"concept_id": "C1166864", "aliases": ["mannosyltransferase complex location"], "types": ["T026"], "canonical_name": "mannosyltransferase complex", "definition": "A complex that posseses mannosyltransferase activity. [GOC:mah]"}
{"concept_id": "C1166865", "aliases": [], "types": ["T026"], "canonical_name": "Golgi medial cisterna", "definition": "The middle Golgi cisterna (or cisternae). [ISBN:0815316194]"}
{"concept_id": "C1166866", "aliases": [], "types": ["T026"], "canonical_name": "Golgi trans cisterna", "definition": "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. [ISBN:0815316194]"}
{"concept_id": "C1166868", "aliases": ["Sec34/35 complex location"], "types": ["T026"], "canonical_name": "Sec34/35 complex"}
{"concept_id": "C1166869", "aliases": [], "types": ["T026"], "canonical_name": "hydrogenosome", "definition": "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation. [GOC:jl, PMID:11197234, PMID:11293569]"}
{"concept_id": "C1166870", "aliases": ["spherosome", "monolayer-surrounded lipid storage body", "oilbody", "oil body"], "types": ["T026"], "definition": "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins. [GOC:mtg_sensu, ISBN:0943088372]", "canonical_name": "oleosome"}
{"concept_id": "C1166871", "aliases": [], "types": ["T026"], "canonical_name": "membrane coat", "definition": "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. [GOC:mah]"}
{"concept_id": "C1166872", "aliases": ["clathrin cage"], "types": ["T026"], "canonical_name": "clathrin coat", "definition": "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. [GOC:mah, PMID:11252894, PMID:9531549]"}
{"concept_id": "C1166873", "aliases": ["clathrin adaptor complex location"], "types": ["T026"], "canonical_name": "clathrin adaptor complex", "definition": "A membrane coat adaptor complex that links clathrin to a membrane. [GOC:mah]"}
{"concept_id": "C1166874", "aliases": [], "types": ["T026"], "canonical_name": "clathrin coat of coated pit", "definition": "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. [GOC:mah]"}
{"concept_id": "C1166876", "aliases": ["AP-3 adaptor complex location"], "types": ["T026"], "canonical_name": "AP-3 adaptor complex", "definition": "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). [GOC:mah, PMID:10611976, PMID:21097499]"}
{"concept_id": "C1166877", "aliases": ["AP-4 adaptor complex location"], "types": ["T026"], "canonical_name": "AP-4 adaptor complex", "definition": "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo. [GOC:mah, PMID:10611976]"}
{"concept_id": "C1166878", "aliases": ["gamma-tubulin ring complex"], "types": ["T026"], "definition": "A complex comprised of gamma tubulin and other proteins that can act as a scaffold for the nucleation of microtubules.", "canonical_name": "gamma-tubulin ring complex location"}
{"concept_id": "C1166879", "aliases": ["gammaTuSC", "gamma-tubulin small complex location"], "types": ["T026"], "canonical_name": "gamma-tubulin small complex", "definition": "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. [PMID:11297925, PMID:12134075]"}
{"concept_id": "C1166881", "aliases": [], "types": ["T026"], "definition": "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. [GOC:clt, ISBN:0815316194]", "canonical_name": "pericentriolar material"}
{"concept_id": "C1166882", "aliases": ["mtEXO"], "types": ["T026"], "definition": "A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer. [PMID:10397341, PMID:9829834]", "canonical_name": "mitochondrial degradosome"}
{"concept_id": "C1166883", "aliases": [], "types": ["T026"], "canonical_name": "mitochondrial derivative", "definition": "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation. [GOC:ma]"}
{"concept_id": "C1166884", "aliases": [], "types": ["T026"], "canonical_name": "major mitochondrial derivative", "definition": "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative. [GOC:mah, PMID:17123504, PMID:24211517, PMID:30802236]"}
{"concept_id": "C1166885", "aliases": [], "types": ["T026"], "canonical_name": "minor mitochondrial derivative", "definition": "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation. [GOC:mah, PMID:17123504, PMID:24211517, PMID:30802236]"}
{"concept_id": "C1166887", "aliases": ["branched-chain alpha-ketoacid dehydrogenase complex", "branched-chain alpha-ketoacid dehydrogenase complex location", "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex location", "BCADH"], "types": ["T026"], "canonical_name": "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex", "definition": "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate. [EC:1.2.4.4]"}
{"concept_id": "C1166888", "aliases": ["mitochondrial electron transfer flavoprotein complex location"], "types": ["T026"], "canonical_name": "mitochondrial electron transfer flavoprotein complex", "definition": "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system. [GOC:mtg_sensu, ISBN:0198506732]"}
{"concept_id": "C1166889", "aliases": ["fatty acid beta-oxidation multienzyme complex location"], "types": ["T026"], "definition": "A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT). [GOC:imk, PMID:12115060, PMID:16472743]", "canonical_name": "fatty acid beta-oxidation multienzyme complex"}
{"concept_id": "C1166891", "aliases": ["mitochondrial endopeptidase Clp complex location"], "types": ["T026"], "canonical_name": "mitochondrial endopeptidase Clp complex", "definition": "A Clp endopeptidase complex located in the mitochondrion. [GOC:mah]"}
{"concept_id": "C1166892", "aliases": ["mitochondrial processing peptidase complex location"], "types": ["T026"], "canonical_name": "mitochondrial processing peptidase complex", "definition": "A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion. [GOC:mah]"}
{"concept_id": "C1166893", "aliases": [], "types": ["T026"], "definition": "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. [GOC:mah, ISBN:0198506732]", "canonical_name": "mitochondrial ribosome"}
{"concept_id": "C1166894", "aliases": [], "types": ["T026"], "canonical_name": "mitochondrial large ribosomal subunit", "definition": "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). [GOC:mcc]"}
{"concept_id": "C1166895", "aliases": ["mitochondrial ribosomal SSU complex", "mitochondrial ribosomal small subunit complex", "mitochondrial ribosomal SSU complex location", "mitochondrial ribosomal small subunit complex location"], "types": ["T026"], "canonical_name": "mitochondrial small ribosomal subunit", "definition": "The smaller of the two subunits of a mitochondrial ribosome. [GOC:mcc]"}
{"concept_id": "C1166896", "aliases": ["mitochondrial oxoglutarate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "mitochondrial oxoglutarate dehydrogenase complex", "definition": "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus. [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975]"}
{"concept_id": "C1166900", "aliases": ["mitochondrial alpha-ketoglutarate dehydrogenase complex"], "types": ["T026"], "definition": "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity. [GOC:mah, GOC:mtg_sensu]", "canonical_name": "mitochondrial alpha-ketoglutarate dehydrogenase complex location"}
{"concept_id": "C1166901", "aliases": ["mitochondrial isocitrate dehydrogenase complex location (NAD+)"], "types": ["T026"], "canonical_name": "mitochondrial isocitrate dehydrogenase complex (NAD+)", "definition": "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1166904", "aliases": ["m-AAA complex location"], "types": ["T026"], "canonical_name": "m-AAA complex", "definition": "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria. [GOC:mcc, PMID:12417197, PMID:21147776]"}
{"concept_id": "C1166906", "aliases": ["mitochondrial respiratory chain complex I"], "types": ["T026"], "definition": "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. [GOC:mtg_sensu, ISBN:0198547684]", "canonical_name": "mitochondrial respiratory chain complex I location"}
{"concept_id": "C1166908", "aliases": ["mitochondrial fumarate reductase complex", "mitochondrial respiratory chain complex II, succinate dehydrogenase complex location (ubiquinone)", "mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)"], "types": ["T026"], "definition": "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. [GOC:mtg_sensu, GOC:vw, ISBN:0198547684]", "canonical_name": "mitochondrial fumarate reductase complex location"}
{"concept_id": "C1166911", "aliases": ["mitochondrial coenzyme Q-cytochrome c reductase complex", "mitochondrial cytochrome bc1 complex location", "mitochondrial complex III location", "mitochondrial ubiquinol-cytochrome c oxidoreductase complex location", "mitochondrial ubiquinol-cytochrome-c reductase complex location", "mitochondrial cytochrome bc(1) complex location", "mitochondrial respiratory chain complex III", "mitochondrial coenzyme Q-cytochrome c reductase complex location", "mitochondrial cytochrome bc(1) complex", "mitochondrial cytochrome bc1 complex", "mitochondrial ubiquinol-cytochrome c oxidoreductase complex", "mitochondrial ubiquinol-cytochrome-c reductase complex", "mitochondrial complex III", "mitochondrial respiratory chain complex III location", "mitochondrial coenzyme Q-cytochrome c oxidoreductase complex location", "mitochondrial electron transport complex III", "mitochondrial electron transport complex III location"], "types": ["T026"], "definition": "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. [GOC:mtg_sensu, ISBN:0198547684]", "canonical_name": "mitochondrial coenzyme Q-cytochrome c oxidoreductase complex"}
{"concept_id": "C1166913", "aliases": ["mitochondrial respiratory chain complex IV location"], "types": ["T026"], "definition": "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). [GOC:mtg_sensu, ISBN:0198547684]", "canonical_name": "mitochondrial respiratory chain complex IV"}
{"concept_id": "C1166915", "aliases": ["mitochondrial respiratory chain complex V location", "mitochondrial proton-transporting ATP synthase complex location", "mitochondrial respiratory chain complex V"], "types": ["T026"], "definition": "A proton-transporting ATP synthase complex found in the mitochondrial membrane. [GOC:mah, GOC:mtg_sensu]", "canonical_name": "mitochondrial proton-transporting ATP synthase complex"}
{"concept_id": "C1166916", "aliases": ["mitochondrial proton-transporting ATP synthase complex location, catalytic sector F(1)"], "types": ["T026"], "definition": "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. [GOC:mtg_sensu, PMID:10838056]", "canonical_name": "mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)"}
{"concept_id": "C1166917", "aliases": [], "types": ["T026"], "canonical_name": "mitochondrial proton-transporting ATP synthase, catalytic core", "definition": "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. [GOC:mtg_sensu, PMID:10838056]"}
{"concept_id": "C1166918", "aliases": [], "types": ["T026"], "canonical_name": "mitochondrial proton-transporting ATP synthase, central stalk", "definition": "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis. [GOC:mtg_sensu, PMID:10838056]"}
{"concept_id": "C1166919", "aliases": ["mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)"], "types": ["T026"], "definition": "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. [GOC:mtg_sensu, PMID:10838056]", "canonical_name": "mitochondrial proton-transporting ATP synthase complex location, coupling factor F(o)"}
{"concept_id": "C1166922", "aliases": ["mitochondrial outer membrane translocase complex location", "mitochondrion outer membrane translocase complex", "mitochondrion outer membrane translocase complex location"], "types": ["T026"], "definition": "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments. [PMID:12581629]", "canonical_name": "mitochondrial outer membrane translocase complex"}
{"concept_id": "C1166924", "aliases": ["editosome", "mRNA editing complex location"], "types": ["T026"], "canonical_name": "mRNA editing complex", "definition": "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes. [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607, PMID:24316715]"}
{"concept_id": "C1166925", "aliases": [], "types": ["T026"], "canonical_name": "Nebenkern", "definition": "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme. [GOC:ma, PMID:25265054]"}
{"concept_id": "C1166926", "aliases": ["mRNA cap complex location"], "types": ["T026"], "canonical_name": "mRNA cap complex"}
{"concept_id": "C1166927", "aliases": [], "types": ["T026"], "definition": "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils. [GOC:mtg_muscle, ISBN:0815316194]", "canonical_name": "striated muscle myosin thick filament"}
{"concept_id": "C1166930", "aliases": [], "types": ["T026"], "canonical_name": "smooth muscle dense body", "definition": "Electron-dense region associated with a smooth muscle contractile fiber. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1166931", "aliases": ["NAC", "nascent polypeptide-associated complex location", "NACA"], "types": ["T026"], "definition": "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. [PMID:12475173, PMID:7568149]", "canonical_name": "nascent polypeptide-associated complex"}
{"concept_id": "C1166932", "aliases": ["cytosolic oxoglutarate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "cytosolic oxoglutarate dehydrogenase complex", "definition": "A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). [GOC:mtg_sensu, PMID:10848975]"}
{"concept_id": "C1166933", "aliases": [], "types": ["T026"], "definition": "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms. [PMID:10629216]", "canonical_name": "P1 peroxisome"}
{"concept_id": "C1166934", "aliases": [], "types": ["T026"], "definition": "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed. [PMID:10629216]", "canonical_name": "P2 peroxisome"}
{"concept_id": "C1166935", "aliases": [], "types": ["T026"], "definition": "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content. [PMID:10629216]", "canonical_name": "P3 peroxisome"}
{"concept_id": "C1166936", "aliases": [], "types": ["T026"], "definition": "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content. [PMID:10629216]", "canonical_name": "P4 peroxisome"}
{"concept_id": "C1166937", "aliases": [], "types": ["T026"], "definition": "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content. [PMID:10629216]", "canonical_name": "P5 peroxisome"}
{"concept_id": "C1166938", "aliases": [], "types": ["T026"], "definition": "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes. [PMID:10629216]", "canonical_name": "P6 peroxisome"}
{"concept_id": "C1166939", "aliases": ["peroxisomal lumen"], "types": ["T026"], "canonical_name": "peroxisomal matrix", "definition": "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. [GOC:curators, ISBN:0815316194]"}
{"concept_id": "C1166941", "aliases": ["integral to peroxisomal membrane"], "types": ["T026"], "canonical_name": "integral component of peroxisomal membrane", "definition": "The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:mah]"}
{"concept_id": "C1166942", "aliases": ["extrinsic to intraperoxisomal membrane"], "types": ["T026"], "canonical_name": "extrinsic component of intraperoxisomal membrane", "definition": "The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:jl, GOC:mah]"}
{"concept_id": "C1166945", "aliases": ["phosphoenolpyruvate-dependent sugar phosphotransferase complex location"], "types": ["T026"], "canonical_name": "phosphoenolpyruvate-dependent sugar phosphotransferase complex", "definition": "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system). [GOC:ma]"}
{"concept_id": "C1166946", "aliases": [], "types": ["T026"], "canonical_name": "phragmoplast", "definition": "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules. [ISBN:0471245208]"}
{"concept_id": "C1166947", "aliases": [], "types": ["T026"], "canonical_name": "phragmosome", "definition": "A flattened membranous vesicle containing cell wall components. [ISBN:0943088399]"}
{"concept_id": "C1166948", "aliases": [], "types": ["T026"], "definition": "A plastid whose main function is to synthesize and store starch. [ISBN:0140514031]", "canonical_name": "amyloplast"}
{"concept_id": "C1166949", "aliases": ["amyloplast starch granule"], "types": ["T026"], "canonical_name": "amyloplast starch grain", "definition": "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. [GOC:jl, PMID:11217978]"}
{"concept_id": "C1166950", "aliases": [], "types": ["T026"], "definition": "The plastid organelle found in apicomplexans. [ISBN:0521664470]", "canonical_name": "apicoplast"}
{"concept_id": "C1166951", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast envelope", "definition": "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. [GOC:tb]"}
{"concept_id": "C1166952", "aliases": ["chloroplast inner envelope"], "types": ["T026"], "canonical_name": "chloroplast inner membrane", "definition": "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. [GOC:tb]"}
{"concept_id": "C1166953", "aliases": ["chloroplast outer envelope"], "types": ["T026"], "canonical_name": "chloroplast outer membrane", "definition": "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. [GOC:tb]"}
{"concept_id": "C1166954", "aliases": ["chloroplast starch granule"], "types": ["T026"], "canonical_name": "chloroplast starch grain", "definition": "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1166955", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast stroma", "definition": "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. [ISBN:0198547684]"}
{"concept_id": "C1166956", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast stromal thylakoid", "definition": "Unstacked thylakoids that connect the grana stacks through the stroma. [ISBN:0943088399]"}
{"concept_id": "C1166957", "aliases": ["chloroplastic endopeptidase Clp complex location"], "types": ["T026"], "canonical_name": "chloroplastic endopeptidase Clp complex", "definition": "A Clp endopeptidase complex located in the chloroplast. [GOC:mah]"}
{"concept_id": "C1166958", "aliases": ["RubisCO complex location", "RubisCO complex", "ribulose bisphosphate carboxylase complex", "ribulose bisphosphate carboxylase complex location"], "types": ["T026"], "canonical_name": "ribulose bisphosphate carboxylase complex", "definition": "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. [GOC:mlg]"}
{"concept_id": "C1166959", "aliases": ["ferredoxin-thioredoxin reductase complex location", "ferredoxin:thioredoxin reductase complex location", "ferredoxin:thioredoxin reductase complex"], "types": ["T026"], "canonical_name": "ferredoxin-thioredoxin reductase complex", "definition": "A protein complex that possesses ferredoxin-thioredoxin reductase activity. [GOC:mah]"}
{"concept_id": "C1166960", "aliases": ["chloroplast stacked thylakoid"], "types": ["T026"], "canonical_name": "granal stacked thylakoid", "definition": "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II. [GOC:lr]"}
{"concept_id": "C1166961", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast thylakoid", "definition": "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana. [GOC:mtg_sensu, ISBN:0943088399]"}
{"concept_id": "C1166962", "aliases": ["chloroplast ATP synthase complex location"], "types": ["T026"], "canonical_name": "chloroplast ATP synthase complex", "definition": "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts. [ISBN:0198547684]"}
{"concept_id": "C1166963", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast thylakoid lumen", "definition": "The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana. [GOC:mtg_sensu, ISBN:0943088399]"}
{"concept_id": "C1166964", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast thylakoid membrane", "definition": "The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. [GOC:lr, GOC:mtg_sensu]"}
{"concept_id": "C1166965", "aliases": ["chloroplast hydrogen-translocating F-type ATPase complex location", "chloroplast hydrogen-translocating F-type ATPase complex", "chloroplast proton-transporting F-type ATPase complex", "chloroplast proton-transporting ATP synthase complex location", "chloroplast proton-transporting F-type ATPase complex location"], "types": ["T026"], "canonical_name": "chloroplast proton-transporting ATP synthase complex", "definition": "A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation. [GOC:mtg_sensu, GOC:pj, ISBN:0716743663]"}
{"concept_id": "C1166966", "aliases": ["thylakoid light-harvesting complex location"], "types": ["T026"], "canonical_name": "thylakoid light-harvesting complex", "definition": "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana. [GOC:mtg_sensu, ISBN:0198547684]"}
{"concept_id": "C1166967", "aliases": ["LHCI", "PSI associated light-harvesting complex I location"], "types": ["T026"], "canonical_name": "PSI associated light-harvesting complex I", "definition": "Protein-pigment complex associated with photosystem I. [GOC:lr]"}
{"concept_id": "C1166968", "aliases": ["PSI associated light-harvesting complex I, LHCIa subcomplex location"], "types": ["T026"], "canonical_name": "PSI associated light-harvesting complex I, LHCIa subcomplex", "definition": "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm. [PMID:8825475]"}
{"concept_id": "C1166969", "aliases": ["PSI associated light-harvesting complex I, LHCIb subcomplex location"], "types": ["T026"], "canonical_name": "PSI associated light-harvesting complex I, LHCIb subcomplex", "definition": "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm. [PMID:8825475]"}
{"concept_id": "C1166970", "aliases": ["LHCII", "PSII associated light-harvesting complex II location"], "types": ["T026"], "canonical_name": "PSII associated light-harvesting complex II", "definition": "Protein-pigment complex associated with photosystem II. [GOC:lr, ISBN:0582227089]"}
{"concept_id": "C1166971", "aliases": ["PSII associated light-harvesting complex II, core complex location"], "types": ["T026"], "canonical_name": "PSII associated light-harvesting complex II, core complex", "definition": "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center. [GOC:lr]"}
{"concept_id": "C1166974", "aliases": ["PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex", "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex location", "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex location", "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex location", "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex"], "types": ["T026"], "canonical_name": "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1166975", "aliases": ["PSII associated light-harvesting complex II, peripheral complex location"], "types": ["T026"], "canonical_name": "PSII associated light-harvesting complex II, peripheral complex", "definition": "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light. [GOC:lr]"}
{"concept_id": "C1166976", "aliases": ["PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex location"], "types": ["T026"], "canonical_name": "PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex", "definition": "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides. [PMID:8825475]"}
{"concept_id": "C1166978", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast photosystem II", "definition": "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1166979", "aliases": [], "types": ["T026"], "canonical_name": "chromoplast stroma", "definition": "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material. [GOC:jl]"}
{"concept_id": "C1166980", "aliases": ["muroplast", "cyanoplast"], "types": ["T026"], "canonical_name": "cyanelle", "definition": "A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a double membrane with a peptidoglycan layer in the intermembrane space between the two envelope membranes. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid. [ISBN:0521316871, ISBN:1402001894]"}
{"concept_id": "C1166981", "aliases": [], "types": ["T026"], "canonical_name": "cyanelle thylakoid", "definition": "A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria. [GOC:lr, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1166982", "aliases": ["plasma membrane photosystem I"], "types": ["T026"], "canonical_name": "plasma membrane-derived photosystem I", "definition": "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1166983", "aliases": ["plasma membrane photosystem II"], "types": ["T026"], "canonical_name": "plasma membrane-derived thylakoid photosystem II", "definition": "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1166985", "aliases": [], "types": ["T026"], "canonical_name": "elaioplast", "definition": "A leucoplast in which oil is stored. [ISBN:0140514031]"}
{"concept_id": "C1166986", "aliases": [], "types": ["T026"], "canonical_name": "elaioplast stroma", "definition": "The space enclosed by the double membrane of an elaioplast. [GOC:mah]"}
{"concept_id": "C1166987", "aliases": [], "types": ["T026"], "definition": "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions. [ISBN:0943088399]", "canonical_name": "etioplast"}
{"concept_id": "C1166988", "aliases": [], "types": ["T026"], "canonical_name": "etioplast prolamellar body", "definition": "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast. [ISBN:0140514031]"}
{"concept_id": "C1166989", "aliases": [], "types": ["T026"], "canonical_name": "etioplast stroma", "definition": "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA. [GOC:jl]"}
{"concept_id": "C1166990", "aliases": [], "types": ["T026"], "definition": "A colorless plastid involved in the synthesis of monoterpenes. [ISBN:0943088399]", "canonical_name": "leucoplast"}
{"concept_id": "C1166991", "aliases": [], "types": ["T026"], "canonical_name": "leucoplast stroma", "definition": "The space enclosed by the double membrane of a leucoplast. [GOC:mah]"}
{"concept_id": "C1166992", "aliases": [], "types": ["T026"], "canonical_name": "plastid envelope", "definition": "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space. [GOC:jy]"}
{"concept_id": "C1166993", "aliases": [], "types": ["T026"], "canonical_name": "plastid membrane", "definition": "Either of the lipid bilayers that surround a plastid and form the plastid envelope. [GOC:mah]"}
{"concept_id": "C1166994", "aliases": [], "types": ["T026"], "canonical_name": "plastid inner membrane", "definition": "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma. [GOC:lr]"}
{"concept_id": "C1166995", "aliases": ["plastid envelope lumen"], "types": ["T026"], "canonical_name": "plastid intermembrane space", "definition": "The region between the inner and outer lipid bilayers of the plastid envelope. [GOC:lr]"}
{"concept_id": "C1166996", "aliases": [], "types": ["T026"], "canonical_name": "plastid outer membrane", "definition": "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope. [GOC:lr]"}
{"concept_id": "C1166997", "aliases": [], "types": ["T026"], "canonical_name": "plastid stroma", "definition": "The proteinaceous ground substance of plastids. [ISBN:0943088399]"}
{"concept_id": "C1166998", "aliases": [], "types": ["T026"], "canonical_name": "plastid ribosome", "definition": "A ribosome contained within a plastid. [GOC:tair_curators]"}
{"concept_id": "C1166999", "aliases": [], "types": ["T026"], "canonical_name": "plastid large ribosomal subunit", "definition": "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). [GOC:mcc]"}
{"concept_id": "C1167000", "aliases": [], "types": ["T026"], "canonical_name": "plastid small ribosomal subunit", "definition": "The smaller of the two subunits of a plastid ribosome. [GOC:mcc]"}
{"concept_id": "C1167001", "aliases": [], "types": ["T026"], "canonical_name": "proplastid stroma", "definition": "The space enclosed by the double membrane of a proplastid. [GOC:jl]"}
{"concept_id": "C1167002", "aliases": [], "types": ["T026"], "canonical_name": "proplastid", "definition": "The precursor of other plastids. [ISBN:0943088399]"}
{"concept_id": "C1167003", "aliases": ["polar plasm"], "types": ["T026"], "canonical_name": "pole plasm", "definition": "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. [GOC:kmv, PMID:17113380]"}
{"concept_id": "C1167005", "aliases": [], "types": ["T026"], "canonical_name": "preprophase band", "definition": "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs. [ISBN:0198506732]"}
{"concept_id": "C1167007", "aliases": ["cytosolic pyruvate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "cytosolic pyruvate dehydrogenase complex", "definition": "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094]"}
{"concept_id": "C1167008", "aliases": ["large ribosomal subunit"], "types": ["T026"], "definition": "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). [ISBN:0198506732]", "canonical_name": "ribosomal large subunit"}
{"concept_id": "C1167009", "aliases": [], "types": ["T026"], "canonical_name": "organellar large ribosomal subunit", "definition": "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). [GOC:mcc]"}
{"concept_id": "C1167010", "aliases": [], "types": ["T026"], "canonical_name": "organellar ribosome", "definition": "A ribosome contained within a subcellular membrane-bounded organelle. [GOC:mah, GOC:mcc]"}
{"concept_id": "C1167011", "aliases": [], "types": ["T026"], "canonical_name": "organellar small ribosomal subunit", "definition": "The smaller of the two subunits of an organellar ribosome. [GOC:mcc]"}
{"concept_id": "C1167012", "aliases": ["small ribosomal subunit"], "types": ["T026"], "definition": "The smaller of the two subunits of a ribosome. [GOC:mah]", "canonical_name": "ribosomal small subunit"}
{"concept_id": "C1167015", "aliases": ["snRNA cap binding complex location"], "types": ["T026"], "canonical_name": "snRNA cap binding complex"}
{"concept_id": "C1167016", "aliases": [], "types": ["T026"], "canonical_name": "spectrosome", "definition": "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome. [GOC:bf]"}
{"concept_id": "C1167017", "aliases": ["cytosolic tricarboxylic acid cycle enzyme complex location"], "types": ["T026"], "canonical_name": "cytosolic tricarboxylic acid cycle enzyme complex", "definition": "Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1167018", "aliases": ["cytosolic alpha-ketoglutarate dehydrogenase complex"], "types": ["T026"], "definition": "Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity. [GOC:mah, GOC:mtg_sensu]", "canonical_name": "cytosolic alpha-ketoglutarate dehydrogenase complex location"}
{"concept_id": "C1167019", "aliases": ["cytosolic isocitrate dehydrogenase complex location (NAD+)"], "types": ["T026"], "canonical_name": "cytosolic isocitrate dehydrogenase complex (NAD+)", "definition": "Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1167021", "aliases": [], "types": ["T026"], "canonical_name": "contractile vacuole", "definition": "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. One of its functions is osmoregulatory. [GOC:jl, PMID:10503189, PMID:23890380]"}
{"concept_id": "C1167022", "aliases": [], "types": ["T026"], "canonical_name": "lytic vacuole", "definition": "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. [GOC:krc]"}
{"concept_id": "C1167024", "aliases": ["digestive vacuole"], "types": ["T026"], "canonical_name": "food vacuole", "definition": "Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa. [GOC:mb]"}
{"concept_id": "C1167026", "aliases": ["lysosomal proton-transporting V-type ATPase complex location", "lysosomal hydrogen-translocating V-type ATPase complex", "lysosomal hydrogen-translocating V-type ATPase complex location"], "types": ["T026"], "canonical_name": "lysosomal proton-transporting V-type ATPase complex", "definition": "A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen. [GOC:mah, ISBN:0716743663, PMID:16449553]"}
{"concept_id": "C1167029", "aliases": [], "types": ["T026"], "canonical_name": "lytic vacuole within protein storage vacuole", "definition": "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole. [PMID:11739490]"}
{"concept_id": "C1167030", "aliases": ["vacuole, cell cycle-correlated morphology"], "types": ["T026"], "canonical_name": "fungal-type vacuole", "definition": "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. [GOC:mah, GOC:mtg_sensu, ISBN:0879693649]"}
{"concept_id": "C1167032", "aliases": ["fungal-type vacuolar membrane", "membrane of vacuole with cell cycle-correlated morphology"], "types": ["T026"], "canonical_name": "fungal-type vacuole membrane", "definition": "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. [GOC:krc, GOC:mtg_sensu]"}
{"concept_id": "C1167033", "aliases": ["SCV", "parasitophorous vacuole"], "types": ["T026"], "canonical_name": "symbiont-containing vacuole", "definition": "Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont. [GOC:jl, GOC:mb]"}
{"concept_id": "C1167034", "aliases": ["parasitophorous vacuolar membrane"], "types": ["T026"], "canonical_name": "symbiont-containing vacuole membrane", "definition": "The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont. [GOC:jl, GOC:mb]"}
{"concept_id": "C1167035", "aliases": ["parasitophorous vacuolar membrane network", "symbiont-containing vacuole membrane network"], "types": ["T026"], "canonical_name": "symbiont-containing vacuolar membrane network", "definition": "Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm. [GOC:jl, PMID:3528173]"}
{"concept_id": "C1167036", "aliases": ["parasitophorous vacuolar space"], "types": ["T026"], "canonical_name": "symbiont-containing vacuolar space", "definition": "The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane. [GOC:jl, GOC:mb]"}
{"concept_id": "C1167037", "aliases": [], "types": ["T026"], "canonical_name": "storage vacuole", "definition": "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules. [GOC:krc]"}
{"concept_id": "C1167038", "aliases": [], "types": ["T026"], "canonical_name": "protein storage vacuole", "definition": "A storage vacuole that contains a lytic vacuole; identified in plants. [PMID:11739409]"}
{"concept_id": "C1167039", "aliases": [], "types": ["T026"], "canonical_name": "vacuolar lumen", "definition": "The volume enclosed within the vacuolar membrane. [ISBN:0198506732]"}
{"concept_id": "C1167040", "aliases": ["lumen of vacuole with cell cycle-independent morphology"], "types": ["T026"], "canonical_name": "plant-type vacuole lumen", "definition": "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana. [GOC:krc, GOC:mtg_sensu]"}
{"concept_id": "C1167041", "aliases": ["vacuolar membrane"], "types": ["T026"], "canonical_name": "vacuolar membrane", "definition": "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. [GOC:ai]"}
{"concept_id": "C1167042", "aliases": ["extrinsic to vacuolar membrane"], "types": ["T026"], "canonical_name": "extrinsic component of vacuolar membrane", "definition": "The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:jl, GOC:mah]"}
{"concept_id": "C1167044", "aliases": ["vacuolar hydrogen ion-transporting ATPase V0 domain"], "types": ["T026"], "canonical_name": "vacuolar proton-transporting V-type ATPase, V0 domain", "definition": "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. [GOC:mah, PMID:16449553]"}
{"concept_id": "C1167045", "aliases": ["vacuolar hydrogen ion-transporting ATPase V1 domain"], "types": ["T026"], "canonical_name": "vacuolar proton-transporting V-type ATPase, V1 domain", "definition": "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. [GOC:mah, PMID:16449553]"}
{"concept_id": "C1167046", "aliases": ["membrane of vacuole with cell cycle-independent morphology", "tonoplast"], "types": ["T026"], "canonical_name": "plant-type vacuole membrane", "definition": "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana. [GOC:mtg_sensu, ISBN:0471245208]"}
{"concept_id": "C1167048", "aliases": ["electron transfer flavoprotein complex location", "ETF complex", "ETF complex location"], "types": ["T026"], "canonical_name": "electron transfer flavoprotein complex", "definition": "A protein complex facilitating the electron transfer from an acyl-CoA molecule to ubiquinone via its flavin adenine dinucleotide (FAD) cofactor. Usually contains an alpha and a beta subunit and the structural cofactor adenosine monophosphate (AMP). Part of a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the electron transport system. [GOC:bhm, ISBN:0198506732]"}
{"concept_id": "C1167049", "aliases": ["endopeptidase Clp complex location"], "types": ["T026"], "canonical_name": "endopeptidase Clp complex", "definition": "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form. [GOC:mah, PMID:11352464]"}
{"concept_id": "C1167051", "aliases": ["nuclear exosome multienzyme ribonuclease complex", "eukaryotic exosome multienzyme ribonuclease complex location", "nuclear exosome (ribonuclease complex)", "eukaryotic exosome multienzyme ribonuclease complex", "nuclear exosome multienzyme ribonuclease complex location", "nuclear exosome (ribonuclease complex location)", "nuclear exosome (RNase complex location)"], "types": ["T026"], "canonical_name": "nuclear exosome (RNase complex)", "definition": "A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. [PMID:17174896, PMID:20531386, PMID:26726035]"}
{"concept_id": "C1167052", "aliases": ["extrachromosomal circular DNA location"], "types": ["T026"], "definition": "Circular DNA structures that are not part of a chromosome. [GOC:ai]", "canonical_name": "extrachromosomal circular DNA"}
{"concept_id": "C1167053", "aliases": ["2-micrometer circle DNA location"], "types": ["T026"], "canonical_name": "2-micrometer circle DNA", "definition": "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies. [PMID:12073320]"}
{"concept_id": "C1167054", "aliases": ["extrachromosomal ribosomal DNA circle"], "types": ["T026"], "canonical_name": "extrachromosomal rDNA circle", "definition": "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats. [GOC:mah, PMID:12044934]"}
{"concept_id": "C1167055", "aliases": ["fimbrial shaft"], "types": ["T026"], "canonical_name": "pilus shaft", "definition": "The long, slender, mid section of a pilus. [GOC:jl]"}
{"concept_id": "C1167056", "aliases": ["fimbrial tip"], "types": ["T026"], "canonical_name": "pilus tip", "definition": "The pointed extremity furthest from the cell of a pilus. [GOC:jl]"}
{"concept_id": "C1167059", "aliases": [], "types": ["T026"], "definition": "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. [PMID:11121744]", "canonical_name": "aggresome"}
{"concept_id": "C1167060", "aliases": [], "types": ["T026"], "definition": "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. [GOC:bm, GOC:ma, ISBN:3540076689]", "canonical_name": "nucleoid"}
{"concept_id": "C1167063", "aliases": ["CDK-activating kinase complex", "CAK complex", "cyclin-dependent protein kinase activating kinase holoenzyme complex location", "CAK complex location", "CDK-activating kinase complex location"], "types": ["T026"], "canonical_name": "cyclin-dependent protein kinase activating kinase holoenzyme complex", "definition": "A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. [GOC:bhm, PMID:8752210]"}
{"concept_id": "C1167064", "aliases": ["dosage compensation complex", "dosage compensation complex location"], "types": ["T026"], "canonical_name": "dosage compensation complex", "definition": "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes. [GOC:kmv, GOC:mah]"}
{"concept_id": "C1167066", "aliases": ["female germ-cell nucleus"], "types": ["T026"], "canonical_name": "female germ cell nucleus", "definition": "The nucleus of the female germ cell, a reproductive cell in females. [CL:0000021, GOC:hjd]"}
{"concept_id": "C1167068", "aliases": ["male germ cell nucleus", "male germ-cell nucleus", "sperm cell nucleus"], "types": ["T026"], "canonical_name": "male germ cell nucleus", "definition": "The nucleus of a male germ cell, a reproductive cell in males. [CL:0000015, GOC:hjd, GOC:mtg_sensu]"}
{"concept_id": "C1167069", "aliases": ["nucleus inner membrane", "nuclear inner membrane"], "types": ["T026"], "definition": "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. [GOC:ma]", "canonical_name": "inner nuclear membrane"}
{"concept_id": "C1167070", "aliases": ["integral to nuclear inner membrane"], "types": ["T026"], "canonical_name": "integral component of nuclear inner membrane", "definition": "The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:go_curators]"}
{"concept_id": "C1167072", "aliases": ["nucleus outer envelope", "nuclear outer membrane"], "types": ["T026"], "definition": "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. [ISBN:0198547684]", "canonical_name": "perinuclear membrane"}
{"concept_id": "C1167074", "aliases": ["NLS-dependent protein nuclear import complex location"], "types": ["T026"], "canonical_name": "NLS-dependent protein nuclear import complex", "definition": "A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore. [GOC:jl, PMID:9323123, PMID:9323134, Wikipedia:Importin]"}
{"concept_id": "C1167075", "aliases": ["RNA nuclear export complex location"], "types": ["T026"], "canonical_name": "RNA nuclear export complex", "definition": "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore. [GOC:jl, PMID:9323123]"}
{"concept_id": "C1167076", "aliases": ["nuclear ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "nuclear ubiquitin ligase complex", "definition": "A ubiquitin ligase complex found in the nucleus. [GOC:mah]"}
{"concept_id": "C1167077", "aliases": [], "types": ["T026"], "canonical_name": "dense fibrillar component", "definition": "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins. [PMID:10754561]"}
{"concept_id": "C1167078", "aliases": ["DNA-directed RNA polymerase I complex", "DNA-directed RNA polymerase I complex location", "RNA polymerase I complex location"], "types": ["T026"], "canonical_name": "RNA polymerase I complex", "definition": "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. [GOC:krc, GOC:mtg_sensu]"}
{"concept_id": "C1167079", "aliases": ["fibrillar centre"], "types": ["T026"], "canonical_name": "fibrillar center", "definition": "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]"}
{"concept_id": "C1167080", "aliases": [], "types": ["T026"], "canonical_name": "granular component", "definition": "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm. [PMID:10754561]"}
{"concept_id": "C1167081", "aliases": ["nucleolus organizer complex location"], "types": ["T026"], "canonical_name": "nucleolus organizer complex"}
{"concept_id": "C1167082", "aliases": ["ribonuclease MRP complex location", "RNase MRP complex location", "ribonuclease mitochondrial RNA processing complex location", "RNase MRP complex", "ribonuclease mitochondrial RNA processing complex"], "types": ["T026"], "canonical_name": "ribonuclease MRP complex", "definition": "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714]"}
{"concept_id": "C1167084", "aliases": ["RNA polymerase I transcription factor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase I transcription factor complex"}
{"concept_id": "C1167086", "aliases": ["small nucleolar ribonucleoprotein complex", "sRNP", "sno(s)RNA-containing ribonucleoprotein complex", "small nucleolar ribonucleoprotein", "small nucleolar ribonucleoprotein complex location", "snoRNP"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA. [GOC:krc, GOC:mah, ISBN:0879695897, PMID:17284456]", "canonical_name": "sno(s)RNA-containing ribonucleoprotein complex location"}
{"concept_id": "C1167088", "aliases": ["chromatin accessibility complex", "CHRAC"], "types": ["T026"], "definition": "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair. [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192]", "canonical_name": "chromatin accessibility complex location"}
{"concept_id": "C1167090", "aliases": ["ACF complex", "ATP-utilizing chromatin assembly and remodeling factor complex", "ACF complex location"], "types": ["T026"], "definition": "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair. [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179]", "canonical_name": "ATP-utilizing chromatin assembly and remodeling factor complex location"}
{"concept_id": "C1167091", "aliases": ["chromatin silencing complex location"], "types": ["T026"], "canonical_name": "chromatin silencing complex", "definition": "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing. [GOC:mah]"}
{"concept_id": "C1167092", "aliases": ["PBAF complex", "Polybromo- and BAF containing complex location", "PBAF complex location", "RSC-type complex", "SWI/SNF complex B location", "Polybromo- and BAF containing complex", "SWI/SNF complex B"], "types": ["T026"], "definition": "A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. [GOC:bhm, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231]", "canonical_name": "RSC-type complex location"}
{"concept_id": "C1167093", "aliases": ["SWI/SNF complex location", "SWI-SNF complex location", "SWI-SNF complex"], "types": ["T026"], "canonical_name": "SWI/SNF complex", "definition": "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. [GOC:bhm, PMID:12672490]"}
{"concept_id": "C1167094", "aliases": ["DNA-directed RNA polymerase II, holoenzyme"], "types": ["T026"], "canonical_name": "RNA polymerase II, holoenzyme", "definition": "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters. [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii]"}
{"concept_id": "C1167096", "aliases": ["mediator complex", "L mediator complex", "Srb-mediator complex", "Srb-mediator complex location", "mediator complex location"], "types": ["T026"], "definition": "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. [PMID:11454195, PMID:16168358, PMID:17870225]", "canonical_name": "L mediator complex location"}
{"concept_id": "C1167097", "aliases": ["Paf1 complex location", "Paf1p complex", "Cdc73/Paf1 complex location", "Paf1 complex", "Paf1p complex location"], "types": ["T026"], "canonical_name": "Cdc73/Paf1 complex", "definition": "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p. [PMID:11884586]"}
{"concept_id": "C1167099", "aliases": ["transcription factor TFIIA complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIA complex", "definition": "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12). [GOC:jl, PMID:17560669]"}
{"concept_id": "C1167100", "aliases": ["transcription factor TFIIE complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIE complex", "definition": "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH. [GOC:jl, PMID:16547462]"}
{"concept_id": "C1167101", "aliases": ["transcription factor TFIIF complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIF complex", "definition": "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. [GOC:jl, PMID:7597077]"}
{"concept_id": "C1167104", "aliases": ["RNA polymerase III complex location", "DNA-directed RNA polymerase III complex", "DNA-directed RNA polymerase III complex location"], "types": ["T026"], "canonical_name": "RNA polymerase III complex", "definition": "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. [GOC:krc, GOC:mtg_sensu]"}
{"concept_id": "C1167105", "aliases": ["mRNA cleavage and polyadenylation specificity factor complex location"], "types": ["T026"], "canonical_name": "mRNA cleavage and polyadenylation specificity factor complex", "definition": "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. [PMID:14749727]"}
{"concept_id": "C1167106", "aliases": ["mRNA cleavage factor complex location"], "types": ["T026"], "canonical_name": "mRNA cleavage factor complex", "definition": "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. [GOC:mah, PMID:10357856]"}
{"concept_id": "C1167107", "aliases": ["mRNA cleavage stimulating factor complex location"], "types": ["T026"], "canonical_name": "mRNA cleavage stimulating factor complex", "definition": "A protein complex required for mRNA cleavage but not for poly(A) addition. [GOC:mah, PMID:10357856]"}
{"concept_id": "C1167108", "aliases": [], "types": ["T026"], "canonical_name": "speckle domain"}
{"concept_id": "C1167109", "aliases": [], "types": ["T026"], "definition": "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei. [GOC:jl, PMID:11790299]", "canonical_name": "paraspeckles"}
{"concept_id": "C1167110", "aliases": ["PML nuclear body", "PML NB", "PML body"], "types": ["T026"], "definition": "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. [GOC:ma, PMID:10944585]", "canonical_name": "ND10"}
{"concept_id": "C1167111", "aliases": ["TAP-p15 complex location", "NXF1-NXT1 complex location", "NXF1-NXT1 complex", "Mex67-Mtr2 complex", "TAP-p15 complex", "nuclear RNA export factor complex location", "Mex67-Mtr2 complex location"], "types": ["T026"], "canonical_name": "nuclear RNA export factor complex", "definition": "A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm. [PMID:11780633]"}
{"concept_id": "C1167115", "aliases": ["nucleosome remodeling factor complex", "NURF complex location", "nucleosome remodeling factor complex location"], "types": ["T026"], "canonical_name": "NURF complex", "definition": "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters. [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]"}
{"concept_id": "C1167116", "aliases": ["nuclear pre-replicative complex", "pre-replicative complex location", "nuclear pre-replicative complex location", "eukaryotic pre-replicative complex", "pre-replicative complex", "eukaryotic pre-replicative complex location"], "types": ["T026"], "definition": "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins. [PMID:15222894]", "canonical_name": "pre-RC"}
{"concept_id": "C1167117", "aliases": [], "types": ["T026"], "canonical_name": "replication fork", "definition": "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1167118", "aliases": ["primosome", "primosome complex location"], "types": ["T026"], "canonical_name": "primosome complex", "definition": "Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. [GOC:bhm, GOC:mah, PMID:21856207]"}
{"concept_id": "C1167119", "aliases": ["delta DNA polymerase complex location", "delta-DNA polymerase complex location", "delta-DNA polymerase complex"], "types": ["T026"], "canonical_name": "delta DNA polymerase complex", "definition": "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair. [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]"}
{"concept_id": "C1167121", "aliases": ["DNA replication factor A complex location", "replication protein A", "DNA replication factor A complex"], "types": ["T026"], "definition": "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. [PMID:9242902]", "canonical_name": "RPA"}
{"concept_id": "C1167122", "aliases": ["RFC complex location", "DNA replication factor C complex location", "RFC complex", "activator 1 complex location", "activator 1 complex"], "types": ["T026"], "canonical_name": "DNA replication factor C complex", "definition": "A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides. [PMID:14614842, PMID:14646196, PMID:16172520]"}
{"concept_id": "C1167123", "aliases": ["epsilon DNA polymerase complex location", "DNA polymerase epsilon complex location", "DNA polymerase epsilon complex"], "types": ["T026"], "canonical_name": "epsilon DNA polymerase complex", "definition": "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair. [PMID:15814431, PMID:9745046]"}
{"concept_id": "C1167124", "aliases": ["mini-chromosome maintenance complex", "mini-chromosome maintenance complex location", "MCM complex location"], "types": ["T026"], "canonical_name": "MCM complex", "definition": "A hexameric protein complex required for the initiation and regulation of DNA replication. [GOC:jl, PMID:11282021]"}
{"concept_id": "C1167125", "aliases": ["origin recognition complex location", "origin of replication recognition complex location", "ORC", "origin recognition complex"], "types": ["T026"], "definition": "A multisubunit complex that is located at the replication origins of a chromosome. [GOC:elh]", "canonical_name": "origin of replication recognition complex"}
{"concept_id": "C1167126", "aliases": ["transcription elongation factor complex location"], "types": ["T026"], "canonical_name": "transcription elongation factor complex", "definition": "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. [GOC:jl]"}
{"concept_id": "C1167128", "aliases": ["transcription factor complex location"], "types": ["T026"], "canonical_name": "transcription factor complex"}
{"concept_id": "C1167129", "aliases": ["CCAAT-binding factor complex location"], "types": ["T026"], "canonical_name": "CCAAT-binding factor complex", "definition": "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. [GOC:bhm, PMID:7828851]"}
{"concept_id": "C1167130", "aliases": ["CCR4-NOT complex location"], "types": ["T026"], "canonical_name": "CCR4-NOT complex", "definition": "The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]"}
{"concept_id": "C1167131", "aliases": ["CCR4-NOT core complex location"], "types": ["T026"], "canonical_name": "CCR4-NOT core complex", "definition": "The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p. [GOC:sart, PMID:11113136]"}
{"concept_id": "C1167132", "aliases": ["CBF complex", "CBF complex location", "core-binding factor complex location"], "types": ["T026"], "canonical_name": "core-binding factor complex", "definition": "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit. [PMID:15156179, PMID:8497254]"}
{"concept_id": "C1167133", "aliases": ["ecdysone receptor holocomplex location"], "types": ["T026"], "canonical_name": "ecdysone receptor holocomplex", "definition": "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes. [GOC:bf, PMID:14592980]"}
{"concept_id": "C1167134", "aliases": ["activator ecdysone receptor holocomplex location"], "types": ["T026"], "canonical_name": "activator ecdysone receptor holocomplex"}
{"concept_id": "C1167135", "aliases": ["repressor ecdysone receptor holocomplex location"], "types": ["T026"], "canonical_name": "repressor ecdysone receptor holocomplex"}
{"concept_id": "C1167136", "aliases": ["histone acetyltransferase complex location", "histone acetylase complex location", "histone acetylase complex"], "types": ["T026"], "canonical_name": "histone acetyltransferase complex", "definition": "A protein complex that possesses histone acetyltransferase activity. [GOC:mah]"}
{"concept_id": "C1167137", "aliases": ["KAT2B-containing ATAC complex location", "ADA2A-containing complex", "KAT2A-containing ATAC complex", "Ada-Two-A-containing complex", "Ada Two-A containing complex location", "Ada two A containing complex location", "ADA2A-containing complex location", "KAT2B-containing ATAC complex", "Ada Two-A containing complex", "G-ATAC complex", "Ada two A containing complex", "KAT2A-containing ATAC complex location", "ATAC complex location", "Ada-Two-A-containing complex location", "G-ATAC complex location"], "types": ["T026"], "canonical_name": "ATAC complex", "definition": "A chromatin remodelling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation. [GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424]"}
{"concept_id": "C1167139", "aliases": ["SAGA complex location", "Spt-Ada-Gcn5-acetyltransferase complex location", "Spt-Ada-Gcn5-acetyltransferase complex"], "types": ["T026"], "canonical_name": "SAGA complex", "definition": "A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]"}
{"concept_id": "C1167140", "aliases": ["SALSA complex", "SLIK/SALSA complex location", "SAGA (alt) complex location", "SAGA (alt) complex", "SALSA complex location", "SLIK (SAGA-like) complex location", "SLIK/SALSA complex"], "types": ["T026"], "canonical_name": "SLIK (SAGA-like) complex", "definition": "A SAGA-type histone acetyltransferase complex that contains a smaller form of Spt7 (lacking the SPT8 binding region) than the fungal SAGA complex, and consequently lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction. [PMID:33864814]"}
{"concept_id": "C1167141", "aliases": ["transcription factor TFIIIC complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIIC complex", "definition": "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions. [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097]"}
{"concept_id": "C1167142", "aliases": ["histone deacetylase complex location", "HDAC complex location", "histone deacetylase complex"], "types": ["T026"], "definition": "A protein complex that possesses histone deacetylase activity. [GOC:mah]", "canonical_name": "HDAC complex"}
{"concept_id": "C1167143", "aliases": ["NuRD complex location", "nucleosome remodeling and histone deacetylation complex", "NuRD complex", "NRD complex location", "nucleosome remodeling and histone deacetylation complex location", "Mi-2 complex", "NRD complex"], "types": ["T026"], "definition": "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. [PMID:10589671, PMID:11743021, PMID:17289569]", "canonical_name": "Mi-2 complex location"}
{"concept_id": "C1167144", "aliases": ["Sin3 complex location"], "types": ["T026"], "definition": "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. [PMID:10589671, PMID:11743021, PMID:12865422]", "canonical_name": "Sin3 complex"}
{"concept_id": "C1167145", "aliases": ["insulin control element activator complex location", "ICE activator complex location", "ICE activator complex"], "types": ["T026"], "canonical_name": "insulin control element activator complex", "definition": "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription. [PMID:7935390]"}
{"concept_id": "C1167146", "aliases": ["selectivity factor SL1 complex", "TIF-IB", "RNA polymerase transcription factor SL1 complex location", "selectivity factor SL1 complex location"], "types": ["T026"], "canonical_name": "RNA polymerase transcription factor SL1 complex", "definition": "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48. [PMID:15691654]"}
{"concept_id": "C1167147", "aliases": ["snRNA-activating protein complex location", "SNAPc"], "types": ["T026"], "canonical_name": "snRNA-activating protein complex", "definition": "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters. [PMID:7715707, PMID:9003788]"}
{"concept_id": "C1167148", "aliases": ["transcription factor TFIIIB complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIIB complex", "definition": "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF. [GOC:mah, PMID:11433012]"}
{"concept_id": "C1167149", "aliases": ["transcriptional repressor complex location", "transcriptional repressor complex", "transcription factor inhibitor complex location", "transcription repressor complex location", "transcription factor inhibitor complex"], "types": ["T026"], "canonical_name": "transcription repressor complex", "definition": "A protein complex that possesses activity that prevents or downregulates transcription. [GOC:mah]"}
{"concept_id": "C1167150", "aliases": ["negative cofactor 2 complex location"], "types": ["T026"], "canonical_name": "negative cofactor 2 complex", "definition": "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. [PMID:15574413]"}
{"concept_id": "C1167151", "aliases": ["zeta DNA polymerase complex location"], "types": ["T026"], "canonical_name": "zeta DNA polymerase complex", "definition": "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer. [PMID:16631579, PMID:16971464]"}
{"concept_id": "C1167152", "aliases": ["nucleotide-excision repair complex location"], "types": ["T026"], "definition": "Any complex formed of proteins that act in nucleotide-excision repair. [PMID:10915862]", "canonical_name": "nucleotide-excision repair complex"}
{"concept_id": "C1167153", "aliases": ["XPA-ERCC1-ERCC4 complex", "nucleotide-excision repair factor 1 complex location", "NEF1 complex location", "NEF1 complex", "XPA-ERCC1-ERCC4 complex location"], "types": ["T026"], "canonical_name": "nucleotide-excision repair factor 1 complex", "definition": "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively. [PMID:10915862]"}
{"concept_id": "C1167154", "aliases": ["NEF2 complex location", "NEF2 complex", "nucleotide-excision repair factor 2 complex location"], "types": ["T026"], "canonical_name": "nucleotide-excision repair factor 2 complex", "definition": "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p. [PMID:10915862]"}
{"concept_id": "C1167155", "aliases": ["NEF3 complex", "nucleotide-excision repair factor 3 complex location", "NEF3 complex location"], "types": ["T026"], "canonical_name": "nucleotide-excision repair factor 3 complex", "definition": "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p). [GOC:ew, PMID:10915862, PMID:14500720, PMID:7813015]"}
{"concept_id": "C1167156", "aliases": ["nucleotide-excision repair factor 4 complex location", "NEF4 complex location", "NEF4 complex"], "types": ["T026"], "canonical_name": "nucleotide-excision repair factor 4 complex", "definition": "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p. [PMID:10915862]"}
{"concept_id": "C1167158", "aliases": [], "types": ["T026"], "definition": "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. [ISBN:0198506732]", "canonical_name": "pronucleus"}
{"concept_id": "C1167159", "aliases": ["replication compartment"], "types": ["T026"], "definition": "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously. [PMID:9499108, VZ:1951]", "canonical_name": "RC"}
{"concept_id": "C1167160", "aliases": [], "types": ["T026"], "canonical_name": "signalosome"}
{"concept_id": "C1167161", "aliases": ["ssDNA-dependent ATP-dependent DNA helicase complex", "single-stranded DNA-dependent ATP-dependent DNA helicase complex location", "ssDNA-dependent ATP-dependent DNA helicase complex location"], "types": ["T026"], "canonical_name": "single-stranded DNA-dependent ATP-dependent DNA helicase complex", "definition": "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity. [GOC:mah]"}
{"concept_id": "C1167162", "aliases": ["small nuclear ribonucleoprotein complex", "small nuclear ribonucleoprotein", "snRNP", "snRNP location"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs. [GOC:krc, GOC:mah, ISBN:0879695897]", "canonical_name": "small nuclear ribonucleoprotein complex location"}
{"concept_id": "C1167163", "aliases": ["U1 snRNP location", "snRNP U1", "U1 snRNP"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "canonical_name": "snRNP U1 location"}
{"concept_id": "C1167164", "aliases": ["snRNP U11 location", "snRNP U11", "U11 snRNP location"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains small nuclear RNA U11, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U11 snRNP, most of which remain associated with the U11 snRNA both while the U11 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "canonical_name": "U11 snRNP"}
{"concept_id": "C1167165", "aliases": ["snRNP U12 location", "U12 snRNP", "snRNP U12"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains small nuclear RNA U12, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U12 snRNP, most of which remain associated with the U12 snRNA both while the U12 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "canonical_name": "U12 snRNP location"}
{"concept_id": "C1167166", "aliases": ["U2 snRNP location", "snRNP U2 location", "snRNP U2"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "canonical_name": "U2 snRNP"}
{"concept_id": "C1167167", "aliases": ["U4 snRNP", "U4 snRNP location", "snRNP U4 location"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "canonical_name": "snRNP U4"}
{"concept_id": "C1167168", "aliases": ["snRNP U4atac", "snRNP U4atac location", "U4atac snRNP location"], "types": ["T026"], "canonical_name": "U4atac snRNP", "definition": "A ribonucleoprotein complex that contains small nuclear RNA U4atac, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4atac snRNP, most of which remain associated with the U4atac snRNA both while the U4atac snRNP is free or assembled into the U4atac/U6atac complex or into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]"}
{"concept_id": "C1167169", "aliases": ["U5 snRNP location", "snRNP U5", "snRNP U5 location"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "canonical_name": "U5 snRNP"}
{"concept_id": "C1167170", "aliases": ["snRNP U6 location", "U6 snRNP", "snRNP U6"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "canonical_name": "U6 snRNP location"}
{"concept_id": "C1167171", "aliases": ["U6atac snRNP location", "snRNP U6atac", "snRNP U6atac location"], "types": ["T026"], "canonical_name": "U6atac snRNP", "definition": "A ribonucleoprotein complex that contains small nuclear RNA U6atac, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6atac snRNP, most of which remain associated with the U6atac snRNA both while the U6atac snRNP is free or assembled into the U4atac/U6atac snRNP or into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]"}
{"concept_id": "C1167172", "aliases": ["U7 snRNP", "snRNP U7 location", "U7 snRNP location"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs. [PMID:12872004]", "canonical_name": "snRNP U7"}
{"concept_id": "C1167173", "aliases": ["U4/U6.U5 snRNP complex", "U4/U6.U5 snRNP complex location", "U4/U6 x U5 tri-snRNP complex location"], "types": ["T026"], "canonical_name": "U4/U6 x U5 tri-snRNP complex", "definition": "A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]"}
{"concept_id": "C1167175", "aliases": ["commitment complex location"], "types": ["T026"], "canonical_name": "commitment complex", "definition": "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript. [GOC:krc, ISBN:0879695897, PMID:9150140]"}
{"concept_id": "C1167176", "aliases": [], "types": ["T026"], "canonical_name": "GT-AG spliceosome"}
{"concept_id": "C1167178", "aliases": ["SEN complex location", "tRNA splicing endonuclease complex location", "tRNA splicing endonuclease complex", "SEN complex", "tRNA-intron endonuclease complex location"], "types": ["T026"], "canonical_name": "tRNA-intron endonuclease complex", "definition": "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. [PMID:22391451]"}
{"concept_id": "C1167179", "aliases": ["viral replication complex location"], "types": ["T026"], "canonical_name": "viral replication complex", "definition": "Specific locations and structures in the virus infected cell involved in replicating the viral genome. [ISBN:0781718325]"}
{"concept_id": "C1167180", "aliases": ["oxoglutarate dehydrogenase complex location", "dihydrolipoamide S-succinyltransferase complex", "dihydrolipoamide S-succinyltransferase complex location"], "types": ["T026"], "canonical_name": "oxoglutarate dehydrogenase complex", "definition": "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). [MetaCyc:CPLX66-42, PMID:10848975]"}
{"concept_id": "C1167181", "aliases": ["1,3-beta-glucan synthase complex", "(1->3)-beta-glucan synthase complex", "(1->3)-beta-glucan synthase complex location", "1,3-beta-D-glucan synthase complex location", "1,3-beta-glucan synthase complex location"], "types": ["T026"], "canonical_name": "1,3-beta-D-glucan synthase complex", "definition": "A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain. [EC:2.4.1.34]"}
{"concept_id": "C1167182", "aliases": [], "types": ["T026"], "definition": "The region of the plasma membrane located at the apical end of the cell. [GOC:curators]", "canonical_name": "apical plasma membrane"}
{"concept_id": "C1167183", "aliases": ["apical lateral plasma membrane"], "types": ["T026"], "definition": "The apical end of the lateral plasma membrane of epithelial cells. [GOC:hb]", "canonical_name": "apicolateral plasma membrane"}
{"concept_id": "C1167184", "aliases": ["B lymphocyte receptor complex location", "B cell receptor complex", "B lymphocyte receptor complex", "B-lymphocyte receptor complex", "B-cell receptor complex location", "B-cell receptor complex", "immunoglobulin complex location, membrane bound", "B cell receptor complex location", "BCR complex", "BCR complex location", "immunoglobulin complex, membrane bound"], "types": ["T026"], "definition": "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. [GOC:add, ISBN:0781735149]", "canonical_name": "B-lymphocyte receptor complex location"}
{"concept_id": "C1167191", "aliases": [], "types": ["T026"], "definition": "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes. [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910]", "canonical_name": "fascia adherens"}
{"concept_id": "C1167192", "aliases": [], "types": ["T030"], "canonical_name": "nephrocyte junction"}
{"concept_id": "C1167193", "aliases": [], "types": ["T026"], "canonical_name": "pleated septate junction", "definition": "A septate junction in which regular arrays of electron-dense septae span the intermembrane space. [PMID:11700298]"}
{"concept_id": "C1167194", "aliases": ["zonula continua"], "types": ["T026"], "canonical_name": "smooth septate junction", "definition": "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions. [PMID:11700298]"}
{"concept_id": "C1167195", "aliases": ["punctum adherens"], "types": ["T026"], "canonical_name": "spot adherens junction", "definition": "A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens. [PMID:11700298]"}
{"concept_id": "C1167197", "aliases": ["plasmodesmatal cytoplasmic annulus"], "types": ["T026"], "canonical_name": "plasmodesmatal cytoplasmic sleeve", "definition": "The space between the plasma membrane and the desmotubule of a plasmodesma. [PMID:29880547]"}
{"concept_id": "C1167198", "aliases": [], "types": ["T026"], "canonical_name": "plasmodesmatal desmotubule", "definition": "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell. [PMID:29880547]"}
{"concept_id": "C1167199", "aliases": [], "types": ["T026"], "canonical_name": "desmotubule central rod"}
{"concept_id": "C1167200", "aliases": [], "types": ["T026"], "canonical_name": "plasmodesmatal plasma membrane", "definition": "The portion of the plasma membrane surrounding a plasmodesma. [GOC:mah]"}
{"concept_id": "C1167201", "aliases": ["simple plasmodesma"], "types": ["T026"], "canonical_name": "primary plasmodesma", "definition": "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis. [PMID:15012255]"}
{"concept_id": "C1167202", "aliases": [], "types": ["T026"], "canonical_name": "secondary plasmodesma", "definition": "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata. [PMID:15012255]"}
{"concept_id": "C1167203", "aliases": ["T-cell receptor complex location", "T cell receptor complex", "T-cell receptor complex", "T lymphocyte receptor complex location", "T-lymphocyte receptor complex", "TCR complex location", "T-lymphocyte receptor complex location", "TCR", "T lymphocyte receptor complex", "T cell receptor complex location"], "types": ["T026"], "definition": "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. [GOC:mah, ISBN:0781735149]", "canonical_name": "TCR complex"}
{"concept_id": "C1167204", "aliases": ["alpha-beta T-lymphocyte receptor complex location", "alpha-beta TCR complex", "alpha-beta T lymphocyte receptor complex location", "alpha-beta T lymphocyte receptor complex", "alpha-beta T-cell receptor complex", "alpha-beta T-lymphocyte receptor complex", "alpha-beta TCR complex location", "alpha-beta T cell receptor complex location", "alpha-beta T-cell receptor complex location"], "types": ["T026"], "canonical_name": "alpha-beta T cell receptor complex", "definition": "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein. [GOC:mah, ISBN:0781735149]"}
{"concept_id": "C1167205", "aliases": ["gamma-delta T-cell receptor complex location", "gamma-delta T lymphocyte receptor complex", "gamma-delta T-cell receptor complex", "gamma-delta TCR complex location", "gamma-delta T-lymphocyte receptor complex location", "gamma-delta T lymphocyte receptor complex location", "gamma-delta T cell receptor complex location", "gamma-delta TCR complex", "gamma-delta T-lymphocyte receptor complex"], "types": ["T026"], "canonical_name": "gamma-delta T cell receptor complex", "definition": "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein. [GOC:mah, ISBN:0781735149]"}
{"concept_id": "C1167206", "aliases": ["auxin efflux carrier complex location"], "types": ["T026"], "canonical_name": "auxin efflux carrier complex", "definition": "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell. [PMID:9843496]"}
{"concept_id": "C1167207", "aliases": [], "types": ["T026"], "definition": "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]", "canonical_name": "basal plasma membrane"}
{"concept_id": "C1167208", "aliases": [], "types": ["T026"], "definition": "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]", "canonical_name": "basolateral plasma membrane"}
{"concept_id": "C1167209", "aliases": [], "types": ["T026"], "canonical_name": "caveolar membrane"}
{"concept_id": "C1167210", "aliases": ["flotillin complex location"], "types": ["T026"], "canonical_name": "flotillin complex", "definition": "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae. [PMID:17206938, PMID:17600709]"}
{"concept_id": "C1167211", "aliases": ["clathrin-coated pit"], "types": ["T026"], "definition": "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]", "canonical_name": "coated pit"}
{"concept_id": "C1167212", "aliases": ["outer surface of cytoplasmic membrane", "external side of plasma membrane"], "types": ["T026"], "definition": "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]", "canonical_name": "external leaflet of plasma membrane"}
{"concept_id": "C1167213", "aliases": ["peripheral plasma membrane protein", "extrinsic to plasma membrane"], "types": ["T026"], "definition": "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:curators, GOC:dos]", "canonical_name": "extrinsic component of plasma membrane"}
{"concept_id": "C1167214", "aliases": ["catenin complex location"], "types": ["T026"], "canonical_name": "catenin complex", "definition": "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. [ISBN:0198599323]"}
{"concept_id": "C1167216", "aliases": ["heterotrimeric G-protein complex"], "types": ["T026"], "definition": "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein. [ISBN:0198547684]", "canonical_name": "heterotrimeric G-protein complex location"}
{"concept_id": "C1167217", "aliases": ["inaD signalling complex", "inaD signalling complex location", "inaD signaling complex location"], "types": ["T026"], "canonical_name": "inaD signaling complex", "definition": "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD. [GOC:hb, PMID:9010208, PMID:9796815]"}
{"concept_id": "C1167220", "aliases": ["integral to plasma membrane"], "types": ["T026"], "canonical_name": "integral component of plasma membrane", "definition": "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:go_curators]"}
{"concept_id": "C1167221", "aliases": ["ATP-sensitive potassium channel complex location", "ATP-sensitive potassium channel complex", "inward rectifying K+ channel"], "types": ["T026"], "canonical_name": "inward rectifying potassium channel", "definition": "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity. [GOC:bhm, PMID:16308567, PMID:16956886]"}
{"concept_id": "C1167222", "aliases": ["glycine-gated chloride channel complex location"], "types": ["T026"], "canonical_name": "glycine-gated chloride channel complex", "definition": "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts. [GOC:mah]"}
{"concept_id": "C1167223", "aliases": ["GM-CSF receptor complex location", "granulocyte macrophage colony stimulating factor receptor complex location", "granulocyte macrophage colony-stimulating factor receptor complex location", "granulocyte macrophage colony stimulating factor receptor complex", "GM-CSF receptor complex"], "types": ["T026"], "canonical_name": "granulocyte macrophage colony-stimulating factor receptor complex", "definition": "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor. [GOC:mah]"}
{"concept_id": "C1167224", "aliases": ["histamine-gated chloride channel complex location"], "types": ["T026"], "canonical_name": "histamine-gated chloride channel complex", "definition": "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts. [GOC:mah]"}
{"concept_id": "C1167225", "aliases": ["hydrogen:potassium-exchanging ATPase complex", "hydrogen/potassium-exchanging ATPase complex location", "potassium:proton exchanging ATPase complex location", "hydrogen:potassium-exchanging ATPase complex location", "potassium:proton exchanging ATPase complex"], "types": ["T026"], "definition": "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present. [PMID:11756431]", "canonical_name": "hydrogen/potassium-exchanging ATPase complex"}
{"concept_id": "C1167226", "aliases": ["insulin receptor complex location"], "types": ["T026"], "canonical_name": "insulin receptor complex", "definition": "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain. [ISBN:0198506732]"}
{"concept_id": "C1167227", "aliases": ["integrin complex location"], "types": ["T026"], "canonical_name": "integrin complex", "definition": "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. [PMID:17543136]"}
{"concept_id": "C1167228", "aliases": ["IL-1 receptor complex", "interleukin-1 receptor complex location", "IL-1 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-1 receptor complex", "definition": "A protein complex that binds interleukin-1; comprises an alpha and a beta subunit. [GOC:mah, InterPro:IPR004075]"}
{"concept_id": "C1167229", "aliases": ["interleukin-12 receptor complex location", "IL-12 receptor complex", "IL-12 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-12 receptor complex", "definition": "A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits. [GOC:ebc, GOC:mah, PMID:10971505]"}
{"concept_id": "C1167230", "aliases": ["interleukin-13 receptor complex location", "IL-13 receptor complex location", "IL-13 receptor complex"], "types": ["T026"], "canonical_name": "interleukin-13 receptor complex", "definition": "A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain. [PMID:8552669, PMID:9013879]"}
{"concept_id": "C1167231", "aliases": ["IL-18 receptor complex location", "interleukin-18 receptor complex location", "IL-18 receptor complex"], "types": ["T026"], "canonical_name": "interleukin-18 receptor complex", "definition": "A protein complex that binds interleukin-18; comprises an alpha and a beta subunit. [GOC:mah, PMID:12759435]"}
{"concept_id": "C1167232", "aliases": ["IL-2 receptor complex", "IL-2 receptor complex location", "interleukin-2 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-2 receptor complex", "definition": "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits. [GOC:mah, PMID:3116143, PMID:8266078]"}
{"concept_id": "C1167233", "aliases": ["interleukin-3 receptor complex location", "IL-3 receptor complex", "IL-3 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-3 receptor complex", "definition": "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5. [PMID:11839579]"}
{"concept_id": "C1167234", "aliases": ["IL-4 receptor complex", "interleukin-4 receptor complex location", "IL-4 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-4 receptor complex", "definition": "A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor. [PMID:10358772]"}
{"concept_id": "C1167235", "aliases": ["interleukin-5 receptor complex location", "IL-5 receptor complex location", "IL-5 receptor complex"], "types": ["T026"], "canonical_name": "interleukin-5 receptor complex", "definition": "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3. [GOC:mah, PMID:11312115, PMID:11839579]"}
{"concept_id": "C1167236", "aliases": ["IL-6 receptor complex location", "interleukin-6 receptor complex location", "IL-6 receptor complex"], "types": ["T026"], "canonical_name": "interleukin-6 receptor complex", "definition": "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130. [PMID:8083235]"}
{"concept_id": "C1167237", "aliases": ["IL-9 receptor complex", "IL-9 receptor complex location", "interleukin-9 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-9 receptor complex", "definition": "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins. [GOC:mah, PMID:10642536]"}
{"concept_id": "C1167238", "aliases": ["ionotropic glutamate receptor complex location"], "types": ["T026"], "canonical_name": "ionotropic glutamate receptor complex", "definition": "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]"}
{"concept_id": "C1167239", "aliases": ["NMDA-selective glutamate receptor", "N-methyl-D-aspartate selective glutamate receptor complex", "NMDA selective glutamate receptor complex location", "N-methyl-D-aspartate selective glutamate receptor complex location"], "types": ["T026"], "canonical_name": "NMDA selective glutamate receptor complex", "definition": "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]"}
{"concept_id": "C1167240", "aliases": ["acetylcholine-gated channel complex location", "nicotinic acetylcholine-gated receptor-channel complex location", "acetylcholine-gated channel complex"], "types": ["T026"], "definition": "A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]", "canonical_name": "nicotinic acetylcholine-gated receptor-channel complex"}
{"concept_id": "C1167241", "aliases": ["oncostatin-M receptor complex location"], "types": ["T026"], "canonical_name": "oncostatin-M receptor complex", "definition": "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta. [GOC:jl, PMID:8999038]"}
{"concept_id": "C1167243", "aliases": ["sodium:potassium-exchanging ATPase complex location", "sodium:potassium-exchanging ATPase complex", "sodium/potassium-exchanging ATPase complex location"], "types": ["T026"], "definition": "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732]", "canonical_name": "sodium/potassium-exchanging ATPase complex"}
{"concept_id": "C1167244", "aliases": ["voltage-sensitive calcium channel complex location", "voltage-dependent calcium channel complex location", "voltage-gated calcium channel complex location", "voltage gated calcium channel complex location", "voltage-sensitive calcium channel complex", "voltage-dependent calcium channel complex", "voltage gated calcium channel complex"], "types": ["T026"], "canonical_name": "voltage-gated calcium channel complex", "definition": "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah]"}
{"concept_id": "C1167245", "aliases": ["light-activated voltage-sensitive calcium channel complex", "light-activated voltage-gated calcium channel complex location", "light-activated voltage-sensitive calcium channel complex location", "light-activated voltage-dependent calcium channel complex location", "light-activated voltage-dependent calcium channel complex", "light-activated voltage gated calcium channel complex location", "light-activated voltage gated calcium channel complex"], "types": ["T026"], "canonical_name": "light-activated voltage-gated calcium channel complex", "definition": "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus. [GOC:mah, PMID:9223679]"}
{"concept_id": "C1167246", "aliases": ["voltage-sensitive potassium channel complex location", "voltage gated potassium channel complex", "voltage-gated potassium channel complex location", "voltage gated potassium channel complex location", "voltage-sensitive potassium channel complex", "voltage-dependent potassium channel complex", "voltage-dependent potassium channel complex location"], "types": ["T026"], "canonical_name": "voltage-gated potassium channel complex", "definition": "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah]"}
{"concept_id": "C1167247", "aliases": ["voltage gated sodium channel complex location", "voltage-gated sodium channel complex location", "voltage gated sodium channel complex", "voltage-sensitive sodium channel complex", "voltage-dependent sodium channel complex location", "voltage-dependent sodium channel complex", "voltage-sensitive sodium channel complex location"], "types": ["T026"], "canonical_name": "voltage-gated sodium channel complex", "definition": "A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732]"}
{"concept_id": "C1167248", "aliases": ["internal leaflet of plasma membrane", "internal side of plasma membrane"], "types": ["T026"], "definition": "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]", "canonical_name": "cytoplasmic side of plasma membrane"}
{"concept_id": "C1167249", "aliases": [], "types": ["T026"], "definition": "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr]", "canonical_name": "lateral plasma membrane"}
{"concept_id": "C1167250", "aliases": ["membrane raft"], "types": ["T026"], "definition": "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]", "canonical_name": "lipid raft"}
{"concept_id": "C1167253", "aliases": ["plasma membrane proton-transporting ATP synthase complex location, catalytic core F(1)"], "types": ["T026"], "definition": "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species. [GOC:mah, GOC:mtg_sensu, PMID:10838056]", "canonical_name": "plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)"}
{"concept_id": "C1167254", "aliases": [], "types": ["T026"], "canonical_name": "plasma membrane proton-transporting ATP synthase, catalytic core", "definition": "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species. [GOC:mtg_sensu, PMID:10838056]"}
{"concept_id": "C1167255", "aliases": [], "types": ["T026"], "canonical_name": "plasma membrane proton-transporting ATP synthase, central stalk", "definition": "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species. [GOC:mtg_sensu, PMID:10838056]"}
{"concept_id": "C1167256", "aliases": ["plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)", "hydrogen-transporting ATP synthase, coupling factor CF(0)", "hydrogen-transporting ATP synthase, F0 sector", "hydrogen-transporting ATP synthase complex, coupling factor F(o)", "proton-transporting ATP synthase complex, coupling factor F(o)", "proton-transporting ATP synthase complex location, coupling factor F(0)", "plasma membrane proton-transporting ATP synthase complex location, coupling factor F(o)", "proton-transporting ATP synthase complex location, coupling factor F(o)", "hydrogen-transporting ATP synthase complex location, coupling factor F(o)"], "types": ["T026"], "definition": "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. [PMID:10838056]", "canonical_name": "proton-transporting ATP synthase complex, coupling factor F(0)"}
{"concept_id": "C1167258", "aliases": ["plasma membrane respiratory chain complex I"], "types": ["T026"], "definition": "A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species. [GOC:mtg_sensu, ISBN:0198547684]", "canonical_name": "plasma membrane respiratory chain complex I location"}
{"concept_id": "C1167260", "aliases": ["plasma membrane respiratory chain complex II location"], "types": ["T026"], "definition": "A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species. [GOC:mtg_sensu, ISBN:0198547684]", "canonical_name": "plasma membrane respiratory chain complex II"}
{"concept_id": "C1167261", "aliases": ["plasma membrane fumarate reductase complex location"], "types": ["T026"], "canonical_name": "plasma membrane fumarate reductase complex", "definition": "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in bacterial species. [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224]"}
{"concept_id": "C1167262", "aliases": ["plasma membrane succinate dehydrogenase complex"], "types": ["T026"], "definition": "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species. [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701]", "canonical_name": "plasma membrane succinate dehydrogenase complex location"}
{"concept_id": "C1167263", "aliases": ["plasma membrane coenzyme Q-cytochrome c oxidoreductase complex location", "plasma membrane ubiquinol-cytochrome-c reductase complex location", "plasma membrane coenzyme Q-cytochrome c reductase complex location", "plasma membrane respiratory chain complex III location", "plasma membrane coenzyme Q-cytochrome c oxidoreductase complex", "plasma membrane cytochrome bc1 complex", "plasma membrane cytochrome bc1 complex location", "plasma membrane ubiquinol-cytochrome-c reductase complex", "plasma membrane coenzyme Q-cytochrome c reductase complex"], "types": ["T026"], "definition": "A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species. [GOC:mtg_sensu, ISBN:0198547684]", "canonical_name": "plasma membrane respiratory chain complex III"}
{"concept_id": "C1167265", "aliases": ["plasma membrane respiratory chain complex IV location"], "types": ["T026"], "canonical_name": "plasma membrane respiratory chain complex IV", "definition": "A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in bacterial species. [GOC:mtg_sensu, ISBN:0198547684]"}
{"concept_id": "C1167266", "aliases": [], "types": ["T026"], "canonical_name": "rhabdomere", "definition": "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction. [GOC:hb, GOC:sart, PMID:8646774]"}
{"concept_id": "C1167267", "aliases": ["SMC", "subrhabdomeral cisterna"], "types": ["T026"], "definition": "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase. [PMID:11707492, PMID:8646774]", "canonical_name": "submicrovillar cisterna"}
{"concept_id": "C1167268", "aliases": [], "types": ["T026"], "definition": "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. [ISBN:0124325653]", "canonical_name": "ruffle"}
{"concept_id": "C1167269", "aliases": ["plasma membrane succinate dehydrogenase complex location (ubiquinone)"], "types": ["T026"], "canonical_name": "plasma membrane succinate dehydrogenase complex (ubiquinone)", "definition": "The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration. [GOC:kd, GOC:mtg_sensu, ISBN:0198547684]"}
{"concept_id": "C1167271", "aliases": ["plasma membrane-derived thylakoid"], "types": ["T026"], "canonical_name": "bacterial thylakoid", "definition": "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1167273", "aliases": ["light-harvesting complex, core complex location"], "types": ["T026"], "canonical_name": "light-harvesting complex, core complex", "definition": "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria. [GOC:lr]"}
{"concept_id": "C1167274", "aliases": ["LH1 complex location", "B875 antenna complex location", "LH1 complex", "light harvesting complex I location", "light harvesting complex I"], "types": ["T026"], "canonical_name": "B875 antenna complex", "definition": "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm. [GOC:kd]"}
{"concept_id": "C1167275", "aliases": ["light-harvesting complex, peripheral complex location"], "types": ["T026"], "canonical_name": "light-harvesting complex, peripheral complex", "definition": "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center. [GOC:lr]"}
{"concept_id": "C1167276", "aliases": ["LH3 complex", "B800-820 antenna complex location", "LH3 complex location", "light harvesting complex III", "light harvesting complex III location"], "types": ["T026"], "canonical_name": "B800-820 antenna complex", "definition": "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex. [GOC:kd, GOC:lr]"}
{"concept_id": "C1167277", "aliases": ["light harvesting complex II location", "B800-850 antenna complex location", "light harvesting complex II", "LH2 complex", "LH2 complex location"], "types": ["T026"], "canonical_name": "B800-850 antenna complex", "definition": "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex. [GOC:kd, GOC:lr]"}
{"concept_id": "C1167279", "aliases": ["type I protein secretion system complex location"], "types": ["T026"], "canonical_name": "type I protein secretion system complex", "definition": "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space. [PMID:9618447]"}
{"concept_id": "C1167281", "aliases": ["T3SS complex location", "T3SS complex", "TTSS complex", "TTSS complex location", "type III protein secretion system complex location"], "types": ["T026"], "canonical_name": "type III protein secretion system complex", "definition": "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase. [PMID:9618447]"}
{"concept_id": "C1167282", "aliases": ["proton-transporting ATP synthase complex location", "plasma membrane proton-transporting ATP synthase complex", "plasma membrane proton-transporting ATP synthase complex location", "plasma membrane hydrogen-translocating F-type ATPase complex location", "hydrogen-transporting ATP synthase complex", "F1-F0 complex location", "hydrogen-translocating F-type ATPase complex location", "plasma membrane hydrogen-translocating F-type ATPase complex", "proton-transporting ATP synthase complex", "hydrogen-transporting ATP synthase complex location", "hydrogen-translocating F-type ATPase complex", "F1-F0 complex"], "types": ["T026"], "definition": "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. [ISBN:0198547684, ISBN:0716743663]", "canonical_name": "hydrogen-transporting ATP synthase"}
{"concept_id": "C1167284", "aliases": ["proton-transporting ATP synthase, catalytic core", "hydrogen-transporting ATP synthase, catalytic core"], "types": ["T026"], "canonical_name": "proton-transporting ATP synthase, catalytic core", "definition": "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. [PMID:10838056]"}
{"concept_id": "C1167285", "aliases": ["proton-transporting ATP synthase, central stalk", "hydrogen-transporting ATP synthase, central stalk"], "types": ["T026"], "canonical_name": "proton-transporting ATP synthase, central stalk", "definition": "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis. [PMID:10838056]"}
{"concept_id": "C1167287", "aliases": ["hydrogen-transporting ATP synthase, stator stalk", "proton-transporting ATP synthase location, stator stalk", "hydrogen-transporting ATP synthase location, stator stalk", "proton-transporting ATP synthase, stator stalk"], "types": ["T026"], "canonical_name": "proton-transporting ATP synthase, stator stalk", "definition": "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core. [PMID:10838056]"}
{"concept_id": "C1167288", "aliases": ["pyruvate dehydrogenase (lipoamide) phosphatase complex location"], "types": ["T026"], "canonical_name": "pyruvate dehydrogenase (lipoamide) phosphatase complex", "definition": "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. [PMID:9395502]"}
{"concept_id": "C1167289", "aliases": ["pyruvate dehydrogenase complex location", "pyruvate dehydrogenase complex location (lipoamide)", "pyruvate dehydrogenase complex (lipoamide)"], "types": ["T026"], "definition": "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). [ISBN:0716720094]", "canonical_name": "pyruvate dehydrogenase complex"}
{"concept_id": "C1167290", "aliases": ["NADH dehydrogenase (ubiquinone) complex", "NADH dehydrogenase (ubiquinone) complex location", "electron transport complex I location", "NADH dehydrogenase complex (ubiquinone)", "NADH-Q oxidoreductase complex location", "NADH dehydrogenase complex location (ubiquinone)", "respiratory chain complex I location", "NADH-Q oxidoreductase complex", "respiratory chain complex I"], "types": ["T026"], "definition": "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. [GOC:imk, GOC:jid, ISBN:0716749556]", "canonical_name": "electron transport complex I"}
{"concept_id": "C1167292", "aliases": ["electron transport complex II location", "respiratory chain complex II", "electron transport complex II"], "types": ["T026"], "definition": "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. [ISBN:0198547684]", "canonical_name": "respiratory chain complex II location"}
{"concept_id": "C1167293", "aliases": ["fumarate reductase complex location"], "types": ["T026"], "definition": "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). [InterPro:IPR003418, InterPro:IPR004224]", "canonical_name": "fumarate reductase complex"}
{"concept_id": "C1167294", "aliases": ["succinate dehydrogenase complex location"], "types": ["T026"], "definition": "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones. [GOC:kd, InterPro:IPR000701]", "canonical_name": "succinate dehydrogenase complex"}
{"concept_id": "C1167295", "aliases": ["electron transport complex III", "ubiquinol-cytochrome-c reductase complex", "cytochrome bc1 complex", "complex III", "electron transport complex III location", "cytochrome bc(1) complex", "ubiquinol-cytochrome-c reductase complex location", "ubiquinol-cytochrome c oxidoreductase complex location", "cytochrome bc(1) complex location", "ubiquinol-cytochrome c oxidoreductase complex", "cytochrome bc1 complex location", "respiratory chain complex III location", "complex III location"], "types": ["T026"], "definition": "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. [PMID:16228398, PMID:16352458, PMID:17200733]", "canonical_name": "respiratory chain complex III"}
{"concept_id": "C1167297", "aliases": ["electron transport complex IV", "respiratory chain complex IV", "electron transport complex IV location", "cytochrome c oxidase complex", "respiratory chain complex IV location"], "types": ["T026"], "definition": "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). [ISBN:0198547684]", "canonical_name": "cytochrome c oxidase complex location"}
{"concept_id": "C1167298", "aliases": ["RNP", "RNA-protein complex location", "protein-RNA complex location", "protein-RNA complex", "RNA-protein complex", "ribonucleoprotein complex"], "types": ["T026"], "definition": "A macromolecular complex that contains both RNA and protein molecules. [GOC:krc, GOC:vesicles]", "canonical_name": "ribonucleoprotein complex location"}
{"concept_id": "C1167299", "aliases": ["succinate dehydrogenase complex location (ubiquinone)"], "types": ["T026"], "canonical_name": "succinate dehydrogenase complex (ubiquinone)", "definition": "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration. [GOC:kd, ISBN:0198547684]"}
{"concept_id": "C1167300", "aliases": ["TCA cycle enzyme complex", "TCA cycle enzyme complex location", "tricarboxylic acid cycle enzyme complex location", "tricarboxylic acid cycle enzyme complex"], "types": ["T026"], "canonical_name": "tricarboxylic acid cycle enzyme complex", "definition": "Any of the heteromeric enzymes that act in the TCA cycle. [GOC:mah]"}
{"concept_id": "C1167302", "aliases": ["isocitrate dehydrogenase complex (NAD+)", "isocitrate dehydrogenase complex location (NAD+)"], "types": ["T026"], "canonical_name": "isocitrate dehydrogenase complex (NAD+)", "definition": "Complex that possesses isocitrate dehydrogenase (NAD+) activity. [GOC:mah]"}
{"concept_id": "C1167303", "aliases": ["succinate-CoA ligase complex location (GDP-forming)", "succinyl-CoA synthetase, GDP-forming"], "types": ["T026"], "canonical_name": "succinate-CoA ligase complex (GDP-forming)", "definition": "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP. [GOC:jl, PMID:27487822]"}
{"concept_id": "C1167304", "aliases": ["antenna complex location"], "types": ["T026"], "canonical_name": "antenna complex"}
{"concept_id": "C1167305", "aliases": ["plasma membrane light-harvesting complex location"], "types": ["T026"], "canonical_name": "plasma membrane light-harvesting complex", "definition": "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1167307", "aliases": ["cytochrome b6-f complex", "cyt b(6)f complex location", "cyt b6f complex", "cytochrome b(6)f complex", "cytochrome b6f complex location", "cyt b6-f complex", "cytochrome b6-f complex location", "cyt b6f complex location", "cyt b(6)f complex", "cytochrome b(6)f complex location", "cyt b6/f complex", "cyt b6/f complex location", "cytochrome b6f complex", "cytochrome b6/f complex location", "cytochrome b6/f complex"], "types": ["T026"], "definition": "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. [ISBN:0943088399, PMID:16228398, PMID:16352458]", "canonical_name": "cyt b6-f complex location"}
{"concept_id": "C1167308", "aliases": ["photosystem I antenna complex location"], "types": ["T026"], "canonical_name": "photosystem I antenna complex", "definition": "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs). [GOC:jid, ISBN:0716731363]"}
{"concept_id": "C1167309", "aliases": ["photosystem I reaction centre"], "types": ["T026"], "definition": "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin. [GOC:kd, ISBN:0943088399]", "canonical_name": "photosystem I reaction center"}
{"concept_id": "C1167310", "aliases": ["oxygen evolving complex", "photosystem II oxygen evolving complex location", "OEC (PSII) complex location", "OEC (PSII) complex", "oxygen evolving complex location"], "types": ["T026"], "canonical_name": "photosystem II oxygen evolving complex", "definition": "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). [GOC:cjm, InterPro:IPR002683]"}
{"concept_id": "C1167311", "aliases": ["photosystem II antenna complex location"], "types": ["T026"], "canonical_name": "photosystem II antenna complex", "definition": "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs). [GOC:jid, ISBN:0716731363]"}
{"concept_id": "C1167312", "aliases": ["photosystem II reaction center"], "types": ["T026"], "definition": "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone. [GOC:kd, ISBN:0943088399]", "canonical_name": "photosystem II reaction centre"}
{"concept_id": "C1167313", "aliases": ["ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "ubiquitin ligase complex", "definition": "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. [GOC:jh2, PMID:9529603]"}
{"concept_id": "C1167314", "aliases": [], "types": ["T026"], "canonical_name": "virion transport vesicle", "definition": "A vesicle used to transport the partial or complete virion between cellular compartments. [GOC:vesicles, PMID:7933124]"}
{"concept_id": "C1167315", "aliases": [], "types": ["T026"], "canonical_name": "endomembrane system", "definition": "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. [GOC:lh]"}
{"concept_id": "C1167316", "aliases": ["NE-ER continuum", "nuclear envelope-ER network", "nuclear envelope-endoplasmic reticulum continuum", "NE-ER network"], "types": ["T026"], "canonical_name": "nuclear envelope-endoplasmic reticulum network"}
{"concept_id": "C1167317", "aliases": [], "types": ["T026"], "canonical_name": "vesicle membrane", "definition": "The lipid bilayer surrounding any membrane-bounded vesicle in the cell. [GOC:mah, GOC:vesicle]"}
{"concept_id": "C1167320", "aliases": ["extrinsic to membrane", "peripheral membrane protein"], "types": ["T026"], "canonical_name": "extrinsic component of membrane", "definition": "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:jl, GOC:mah]"}
{"concept_id": "C1167322", "aliases": ["integral component of membrane", "integral to membrane"], "types": ["T026"], "definition": "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:go_curators]", "canonical_name": "transmembrane"}
{"concept_id": "C1167323", "aliases": ["hydrogen-transporting two-sector ATPase complex location", "hydrogen-transporting two-sector ATPase complex", "proton-transporting two-sector ATPase complex location"], "types": ["T026"], "canonical_name": "proton-transporting two-sector ATPase complex", "definition": "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. [GOC:mah, ISBN:0716743663, PMID:16691483]"}
{"concept_id": "C1167325", "aliases": ["intracellular cyclic nucleotide activated cation channel complex location"], "types": ["T026"], "canonical_name": "intracellular cyclic nucleotide activated cation channel complex", "definition": "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts. [GOC:mah]"}
{"concept_id": "C1167326", "aliases": ["LPS receptor complex location", "LPS receptor complex", "lipopolysaccharide receptor complex location"], "types": ["T026"], "canonical_name": "lipopolysaccharide receptor complex", "definition": "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens. [PMID:11706042, PMID:9665271]"}
{"concept_id": "C1167327", "aliases": ["PABA peptide hydrolase complex location", "meprin A complex location", "PABA peptide hydrolase complex"], "types": ["T026"], "canonical_name": "meprin A complex", "definition": "A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues. [GOC:mah, MEROPS_fam:M12]"}
{"concept_id": "C1167328", "aliases": ["sodium-transporting two-sector ATPase complex", "sodium-transporting two-sector ATPase complex location", "sodium ion-transporting two-sector ATPase complex location"], "types": ["T026"], "canonical_name": "sodium ion-transporting two-sector ATPase complex", "definition": "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis. [GOC:mah, PMID:14656431]"}
{"concept_id": "C1167329", "aliases": ["sodium ion-transporting F-type ATPase complex location", "sodium-translocating F-type ATPase complex location", "sodium-translocating F-type ATPase complex"], "types": ["T026"], "canonical_name": "sodium ion-transporting F-type ATPase complex", "definition": "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism. [GOC:mah, PMID:14656431]"}
{"concept_id": "C1167330", "aliases": ["sodium-translocating V-type ATPase complex", "sodium-translocating V-type ATPase complex location", "sodium ion-transporting V-type ATPase complex location"], "types": ["T026"], "canonical_name": "sodium ion-transporting V-type ATPase complex", "definition": "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. [GOC:mah, PMID:15802565]"}
{"concept_id": "C1167331", "aliases": [], "types": ["T026"], "definition": "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. [GOC:go_curators]", "canonical_name": "outer membrane"}
{"concept_id": "C1167332", "aliases": [], "types": ["T026"], "definition": "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. [ISBN:0815316194]", "canonical_name": "midbody"}
{"concept_id": "C1167334", "aliases": ["shmoo tip", "mating projection", "conjugation tube"], "types": ["T026"], "definition": "The projection formed by unicellular fungi in response to mating pheromone. [GOC:mcc]", "canonical_name": "shmoo"}
{"concept_id": "C1167335", "aliases": [], "types": ["T026"], "canonical_name": "site of polarized growth", "definition": "Any part of a cell where non-isotropic growth takes place. [GOC:mah]"}
{"concept_id": "C1167339", "aliases": [], "types": ["T026"], "canonical_name": "peptidoglycan"}
{"concept_id": "C1167340", "aliases": ["outer membrane-enclosed periplasmic space", "outer membrane bounded periplasmic space"], "types": ["T026"], "definition": "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. [GOC:mlg, GOC:mtg_sensu]", "canonical_name": "outer membrane-bounded periplasmic space"}
{"concept_id": "C1167341", "aliases": [], "types": ["T026"], "definition": "A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. [GOC:mlg, ISBN:0815108893]", "canonical_name": "peptidoglycan-based cell wall"}
{"concept_id": "C1167342", "aliases": ["20-80nm peptidoglycan-based cell wall", "Gram-positive-bacterium-type cell wall"], "types": ["T026"], "definition": "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria. [GOC:mlg, ISBN:0815108893]", "canonical_name": "cell wall of Gram-positive Bacteria"}
{"concept_id": "C1167343", "aliases": [], "types": ["T026"], "canonical_name": "fungal-type cell wall", "definition": "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure. [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422]"}
{"concept_id": "C1167345", "aliases": [], "types": ["T026"], "canonical_name": "hyphal cell wall", "definition": "The cell wall surrounding a fungal hypha. [GOC:mah]"}
{"concept_id": "C1167347", "aliases": [], "types": ["T026"], "canonical_name": "yeast-form cell wall", "definition": "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form. [GOC:mah, GOC:mcc]"}
{"concept_id": "C1167348", "aliases": ["cellulose and pectin-containing cell wall"], "types": ["T026"], "canonical_name": "plant-type cell wall", "definition": "A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. [ISBN:0471245208]"}
{"concept_id": "C1167349", "aliases": [], "types": ["T026"], "canonical_name": "primary cell wall", "definition": "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present. [GOC:jid, PMID:9442872]"}
{"concept_id": "C1167350", "aliases": [], "types": ["T026"], "canonical_name": "cellulose microfibril", "definition": "A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell. [GOC:jid, ISBN:0943088399]"}
{"concept_id": "C1167351", "aliases": [], "types": ["T026"], "canonical_name": "secondary cell wall", "definition": "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin. [GOC:jid, ISBN:0943088399]"}
{"concept_id": "C1167352", "aliases": [], "types": ["T026"], "canonical_name": "S-layer", "definition": "A crystalline protein layer surrounding some bacteria. [GOC:mlg, ISBN:0815108893]"}
{"concept_id": "C1167353", "aliases": [], "types": ["T026"], "canonical_name": "slime layer", "definition": "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids. [GOC:mlg, Wikipedia:Slime_layer]"}
{"concept_id": "C1167358", "aliases": ["laminin-121 complex", "laminin-3 complex location", "laminin-121 complex location"], "types": ["T026"], "canonical_name": "laminin-3 complex", "definition": "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains. [MEDLINE:95005761]"}
{"concept_id": "C1167359", "aliases": ["laminin-4 complex location", "laminin-221 complex location", "laminin-221 complex"], "types": ["T026"], "canonical_name": "laminin-4 complex", "definition": "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1167363", "aliases": [], "types": ["T026"], "definition": "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. [ISBN:0721639976, PMID:19693541, PMID:21421911]", "canonical_name": "collagen type IV trimer"}
{"concept_id": "C1167364", "aliases": [], "types": ["T026"], "definition": "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]", "canonical_name": "collagen trimer"}
{"concept_id": "C1167365", "aliases": [], "types": ["T026"], "definition": "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils. [ISBN:0721639976, PMID:19693541, PMID:21421911]", "canonical_name": "collagen type VI trimer"}
{"concept_id": "C1167366", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin. [ISBN:0721639976, PMID:19693541]", "canonical_name": "collagen type VII trimer"}
{"concept_id": "C1167367", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane. [GOC:bhm, GOC:dos, ISBN:0721639976]", "canonical_name": "collagen type XIII trimer"}
{"concept_id": "C1167368", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils. [PMID:11158616, PMID:11937714, PMID:21421911]", "canonical_name": "collagen type XV trimer"}
{"concept_id": "C1167369", "aliases": [], "types": ["T026"], "definition": "A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences. [ISBN:0198599587, PMID:21421911]", "canonical_name": "FACIT collagen trimer"}
{"concept_id": "C1167370", "aliases": [], "types": ["T026"], "definition": "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils. [ISBN:0721639976]", "canonical_name": "collagen type IX trimer"}
{"concept_id": "C1167371", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures. [ISBN:0721639976]", "canonical_name": "collagen type XII trimer"}
{"concept_id": "C1167372", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures. [ISBN:0721639976]", "canonical_name": "collagen type XIV trimer"}
{"concept_id": "C1167373", "aliases": [], "types": ["T026"], "definition": "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils. [GOC:mah, PMID:12782140]", "canonical_name": "collagen type XVI trimer"}
{"concept_id": "C1167374", "aliases": [], "types": ["T026"], "definition": "Any triple helical collagen trimer that forms fibrils. [GOC:mah, ISBN:0721639976, PMID:21421911]", "canonical_name": "fibrillar collagen trimer"}
{"concept_id": "C1167375", "aliases": [], "types": ["T026"], "definition": "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils. [GOC:mah, GOC:sl, ISBN:0721639976]", "canonical_name": "collagen type I trimer"}
{"concept_id": "C1167376", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. [ISBN:0721639976]", "canonical_name": "collagen type II trimer"}
{"concept_id": "C1167377", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils. [ISBN:0721639976]", "canonical_name": "collagen type III trimer"}
{"concept_id": "C1167378", "aliases": [], "types": ["T026"], "definition": "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils. [ISBN:0721639976]", "canonical_name": "collagen type V trimer"}
{"concept_id": "C1167379", "aliases": [], "types": ["T026"], "definition": "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils. [ISBN:0721639976]", "canonical_name": "collagen type XI trimer"}
{"concept_id": "C1167380", "aliases": [], "types": ["T026"], "definition": "Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils. [ISBN:0198599587]", "canonical_name": "short-chain collagen trimer"}
{"concept_id": "C1167381", "aliases": [], "types": ["T026"], "definition": "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets. [ISBN:0721639976, PMID:21421911]", "canonical_name": "collagen type VIII trimer"}
{"concept_id": "C1167382", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets). [ISBN:0721639976, PMID:21421911]", "canonical_name": "collagen type X trimer"}
{"concept_id": "C1167383", "aliases": ["terminal complement complex", "TCC", "MAC", "terminal complement complex location", "membrane attack complex location"], "types": ["T026"], "definition": "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow. [GOC:add, ISBN:0198547684, ISBN:068340007X, ISBN:0781735149]", "canonical_name": "membrane attack complex"}
{"concept_id": "C1167384", "aliases": ["post-synaptic membrane"], "types": ["T026"], "definition": "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]", "canonical_name": "postsynaptic membrane"}
{"concept_id": "C1167385", "aliases": ["classical-complement-pathway C3/C5 convertase complex location"], "types": ["T026"], "canonical_name": "classical-complement-pathway C3/C5 convertase complex", "definition": "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone. [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html]"}
{"concept_id": "C1167386", "aliases": ["complement component C1q complex", "C1q", "complement component C1q complex location"], "types": ["T026"], "definition": "A protein-containing complex composed of six subunits of each of the three homologous polypeptide chains C1QA, C1QB, and C1QB. It is a subunit of the complement C1 complex. In addition to complement activation, C1q appears to have roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning. [PMID:29449492]", "canonical_name": "Complement 1q"}
{"concept_id": "C1167389", "aliases": ["insulin-like growth factor binding protein complex location", "IGF binding protein complex location", "IGF binding protein complex"], "types": ["T026"], "canonical_name": "insulin-like growth factor binding protein complex", "definition": "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development. [GOC:jl]"}
{"concept_id": "C1167390", "aliases": ["IGF binary complex", "IGF binary complex location", "insulin-like growth factor binary complex location"], "types": ["T026"], "canonical_name": "insulin-like growth factor binary complex", "definition": "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development. [GOC:jl, PMID:12239079]"}
{"concept_id": "C1167391", "aliases": ["IGF ternary complex", "insulin-like growth factor ternary complex location", "IGF ternary complex location"], "types": ["T026"], "canonical_name": "insulin-like growth factor ternary complex", "definition": "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development. [GOC:jl, PMID:12239079]"}
{"concept_id": "C1167392", "aliases": ["larval serum protein complex location"], "types": ["T026"], "canonical_name": "larval serum protein complex", "definition": "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins. [GOC:jl, PMID:6781759]"}
{"concept_id": "C1167393", "aliases": [], "types": ["T026"], "canonical_name": "middle lamella", "definition": "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells. [ISBN:0471245208]"}
{"concept_id": "C1167394", "aliases": ["fibrinogen complex location", "fibrinogen complex"], "types": ["T026"], "definition": "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. [ISBN:0198547684]", "canonical_name": "fibrinogen"}
{"concept_id": "C1167395", "aliases": ["host cellular component"], "types": ["T001"], "definition": "An organism that nourishes and supports another but does not benefit by the association; recipient of transplanted tissue or organ from a donor.", "canonical_name": "host organism"}
{"concept_id": "C1167396", "aliases": [], "types": ["T026"], "canonical_name": "host cell nucleus", "definition": "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C1167397", "aliases": [], "types": ["T026"], "canonical_name": "host cell plasma membrane", "definition": "The plasma membrane surrounding a host cell. [GOC:mb]"}
{"concept_id": "C1167398", "aliases": ["viral outside membrane"], "types": ["T026"], "definition": "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins. [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]", "canonical_name": "viral envelope"}
{"concept_id": "C1167399", "aliases": [], "types": ["T026"], "canonical_name": "host cell cytoplasm", "definition": "The cytoplasm of a host cell. [GOC:mah]"}
{"concept_id": "C1167400", "aliases": [], "types": ["T026"], "canonical_name": "infected host cell surface knob", "definition": "Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species. [GOC:mb]"}
{"concept_id": "C1167401", "aliases": ["Maurers cleft"], "types": ["T026"], "canonical_name": "Maurer's cleft", "definition": "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton. [PMID:16705161]"}
{"concept_id": "C1167402", "aliases": [], "types": ["T026"], "canonical_name": "intercellular bridge", "definition": "A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. [PMID:9635420]"}
{"concept_id": "C1167404", "aliases": [], "types": ["T026"], "canonical_name": "interstitial matrix", "definition": "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. [PMID:8450001]"}
{"concept_id": "C1167405", "aliases": [], "types": ["T026"], "canonical_name": "viral assembly intermediate", "definition": "Specific locations and structures in the virus infected cell involved in assembling new virions. [ISBN:0781718325]"}
{"concept_id": "C1167406", "aliases": ["pre-integration complex", "pre-integration complex location", "viral integration complex", "PIC"], "types": ["T026"], "definition": "A nucleoprotein complex containing viral genetic material and the viral integrase, required for genome integration into the host's genome. May contain other proteins. [PMID:21037296, PMID:2721960, PMID:29900498]", "canonical_name": "viral integration complex location"}
{"concept_id": "C1167407", "aliases": ["viral transcriptional complex location"], "types": ["T026"], "canonical_name": "viral transcriptional complex", "definition": "Specific locations and structures in the virus infected cell involved in transcribing the viral genome. [ISBN:0781718325]"}
{"concept_id": "C1167408", "aliases": ["immunoglobulin complex", "antibody"], "types": ["T026"], "definition": "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, GOC:jl, ISBN:0781765196]", "canonical_name": "immunoglobulin complex location"}
{"concept_id": "C1167410", "aliases": ["class IA PI3K complex location", "1-phosphatidylinositol-4-phosphate kinase, class IA complex location", "1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex location", "1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex", "phosphatidylinositol 3-kinase complex location, class IA", "phosphoinositide 3-kinase complex, class IA", "1-phosphatidylinositol-4-phosphate kinase, class IA complex", "class IA PI3K complex", "phosphoinositide 3-kinase complex location, class IA"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex, class IA", "definition": "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways. [PMID:9255069, PMID:9759495]"}
{"concept_id": "C1167411", "aliases": ["1-phosphatidylinositol-4-phosphate kinase, class IB complex location"], "types": ["T026"], "canonical_name": "1-phosphatidylinositol-4-phosphate kinase, class IB complex"}
{"concept_id": "C1167412", "aliases": ["platelet-activating factor acetylhydrolase complex", "platelet-activating factor acetylhydrolase complex location", "2-acetyl-1-alkylglycerophosphocholine esterase complex", "1-alkyl-2-acetylglycerophosphocholine esterase complex location", "2-acetyl-1-alkylglycerophosphocholine esterase complex location"], "types": ["T026"], "canonical_name": "1-alkyl-2-acetylglycerophosphocholine esterase complex", "definition": "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF). [GOC:jl, PMID:10542206]"}
{"concept_id": "C1167413", "aliases": ["isopropylmalate isomerase complex", "isopropylmalate isomerase complex location", "3-isopropylmalate dehydratase complex location"], "types": ["T026"], "canonical_name": "3-isopropylmalate dehydratase complex", "definition": "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. [BRENDA:4.2.1.33, GOC:jl, MetaCyc:3-ISOPROPYLMALISOM-CPLX, PMID:7026530]"}
{"concept_id": "C1167414", "aliases": ["3-phenylpropionate dioxygenase complex location"], "types": ["T026"], "canonical_name": "3-phenylpropionate dioxygenase complex", "definition": "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol). [GOC:jl, MetaCyc:HCAMULTI-CPLX, PMID:9603882]"}
{"concept_id": "C1167415", "aliases": ["acetate CoA-transferase complex location"], "types": ["T026"], "canonical_name": "acetate CoA-transferase complex", "definition": "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA. [GOC:jl, PMID:2719476, PMID:8423010]"}
{"concept_id": "C1167416", "aliases": ["acetohydroxyacid synthase complex", "acetohydroxyacid synthase complex location", "acetolactate synthase complex location"], "types": ["T026"], "canonical_name": "acetolactate synthase complex", "definition": "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate. [BRENDA:2.2.1.6, GOC:jl, PMID:16458324, PMID:8756689]"}
{"concept_id": "C1167417", "aliases": ["ACCase complex location", "ACCase complex", "acetyl-CoA carboxylase complex location"], "types": ["T026"], "canonical_name": "acetyl-CoA carboxylase complex", "definition": "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. [GOC:jl, GOC:mah, PMID:12121720]"}
{"concept_id": "C1167418", "aliases": ["alkyl hydroperoxide reductase complex location"], "types": ["T026"], "canonical_name": "alkyl hydroperoxide reductase complex", "definition": "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides. [GOC:jl, PMID:2649484]"}
{"concept_id": "C1167419", "aliases": ["UDP-glucose-glucosephosphate glucosyltransferase complex", "trehalose-6-phosphate synthase complex location", "UDP-glucose-glucosephosphate glucosyltransferase complex location", "trehalose-6-phosphate synthase/phosphatase", "alpha,alpha-trehalose-phosphate synthase complex location (UDP-forming)", "trehalose-6-phosphate synthase complex"], "types": ["T026"], "canonical_name": "alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)", "definition": "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present. [PMID:9837904]"}
{"concept_id": "C1167421", "aliases": ["aminoacyl-tRNA synthetase multienzyme complex location", "multisynthetase complex", "aminoacyl-tRNA synthetase complex", "aminoacyl-tRNA synthetase complex location", "multisynthetase complex location"], "types": ["T026"], "canonical_name": "aminoacyl-tRNA synthetase multienzyme complex", "definition": "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates. [GOC:jl, PMID:16169847]"}
{"concept_id": "C1167423", "aliases": ["anthranilate synthase complex location"], "types": ["T026"], "canonical_name": "anthranilate synthase complex", "definition": "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine. [EC:4.1.3.27, MetaCyc:ANTHRANSYN-CPLX, PMID:4886290]"}
{"concept_id": "C1167424", "aliases": ["aspartate carbamoyltransferase complex location"], "types": ["T026"], "canonical_name": "aspartate carbamoyltransferase complex", "definition": "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides. [PMID:10447693]"}
{"concept_id": "C1167425", "aliases": ["beta-galactosidase complex location"], "types": ["T026"], "canonical_name": "beta-galactosidase complex", "definition": "A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. [PMID:15950161]"}
{"concept_id": "C1167426", "aliases": ["biotin carboxylase complex location"], "types": ["T026"], "canonical_name": "biotin carboxylase complex", "definition": "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2). [EC:6.3.4.14]"}
{"concept_id": "C1167427", "aliases": ["CAAX-protein geranylgeranyltransferase complex location"], "types": ["T026"], "canonical_name": "CAAX-protein geranylgeranyltransferase complex", "definition": "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane. [PMID:9781874]"}
{"concept_id": "C1167428", "aliases": ["calcium/calmodulin-dependent protein kinase complex location", "calcium- and calmodulin-dependent protein kinase complex", "calcium- and calmodulin-dependent protein kinase complex location", "CAMK2"], "types": ["T026"], "definition": "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins. [EC:2.7.11.17]", "canonical_name": "calcium/calmodulin-dependent protein kinase complex"}
{"concept_id": "C1167429", "aliases": ["3',5' cAMP-dependent protein kinase complex", "3',5' cAMP-dependent protein kinase complex location", "PKA", "cAMP-dependent protein kinase complex location", "adenosine 3',5'-cyclophosphate-dependent protein kinase complex", "cyclic AMP-dependent protein kinase complex location", "cyclic AMP-dependent protein kinase complex", "cAMP-dependent protein kinase complex", "adenosine 3',5'-cyclophosphate-dependent protein kinase complex location", "3',5'-cAMP-dependent protein kinase complex"], "types": ["T026"], "definition": "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. [EC:2.7.11.11, ISBN:0198506732]", "canonical_name": "3',5'-cAMP-dependent protein kinase complex location"}
{"concept_id": "C1167430", "aliases": ["carbamoyl phosphate synthase complex", "carbamoyl phosphate synthase complex location", "carbamoyl-phosphate synthase complex location"], "types": ["T026"], "canonical_name": "carbamoyl-phosphate synthase complex", "definition": "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events. [PMID:8626695]"}
{"concept_id": "C1167431", "aliases": ["cysteine-type endopeptidase complex", "cysteine-type endopeptidase complex location", "caspase complex location"], "types": ["T026"], "canonical_name": "caspase complex", "definition": "A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes. [GOC:cna, GOC:mtg_apoptosis, PMID:15569692]"}
{"concept_id": "C1167432", "aliases": ["citrate lyase complex"], "types": ["T026"], "canonical_name": "citrate lyase complex location"}
{"concept_id": "C1167433", "aliases": ["cysteine synthase complex location"], "types": ["T026"], "canonical_name": "cysteine synthase complex", "definition": "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A. [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX]"}
{"concept_id": "C1167434", "aliases": ["cytochrome o ubiquinol oxidase complex location"], "types": ["T026"], "canonical_name": "cytochrome o ubiquinol oxidase complex", "definition": "A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups. [GOC:mah, MetaCyc:CYT-O-UBIOX-CPLX, PMID:11017202, PMID:3052268]"}
{"concept_id": "C1167435", "aliases": ["D-amino-acid dehydrogenase complex location"], "types": ["T026"], "canonical_name": "D-amino-acid dehydrogenase complex", "definition": "A protein complex that possesses D-amino-acid dehydrogenase activity. [GOC:mah]"}
{"concept_id": "C1167436", "aliases": ["2-oxoglutarate dehydrogenase complex", "alpha-ketoglutarate dehydrogenase complex", "dihydrolipoyl dehydrogenase complex", "alpha-ketoglutarate dehydrogenase complex location", "2-oxoglutarate dehydrogenase complex location"], "types": ["T026"], "definition": "A protein complex that possesses alpha-ketoglutarate dehydrogenase activity. [GOC:mah]", "canonical_name": "dihydrolipoyl dehydrogenase complex location"}
{"concept_id": "C1167439", "aliases": ["dimethyl sulphoxide reductase complex", "dimethyl sulphoxide reductase complex location", "dimethyl sulfoxide reductase complex location"], "types": ["T026"], "canonical_name": "dimethyl sulfoxide reductase complex", "definition": "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide. [UM-BBD_enzymeID:e0188]"}
{"concept_id": "C1167440", "aliases": ["DNA polymerase III holoenzyme complex", "DNA polymerase III holoenzyme complex location", "DNA polymerase III complex location"], "types": ["T026"], "canonical_name": "DNA polymerase III complex", "definition": "The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. [PMID:11525729, PMID:12940977, UniProt:P06710]"}
{"concept_id": "C1167441", "aliases": ["DNA polymerase V complex location"], "types": ["T026"], "canonical_name": "DNA polymerase V complex", "definition": "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis. [PMID:10430871, PMID:10542196]"}
{"concept_id": "C1167442", "aliases": ["DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex location"], "types": ["T026"], "canonical_name": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex", "definition": "Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity. [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:Type_II_topoisomerase]"}
{"concept_id": "C1167443", "aliases": ["DNA topoisomerase IV complex location"], "types": ["T026"], "canonical_name": "DNA topoisomerase IV complex", "definition": "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA. [GOC:jl, PMID:7783632]"}
{"concept_id": "C1167445", "aliases": ["enterochelin synthetase complex location", "enterobactin synthetase complex location", "enterochelin synthetase complex"], "types": ["T026"], "canonical_name": "enterobactin synthetase complex", "definition": "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway. [MetaCyc:ENTMULTI-CPLX, PMID:9485415]"}
{"concept_id": "C1167446", "aliases": ["ethanolamine ammonia-lyase complex location"], "types": ["T026"], "canonical_name": "ethanolamine ammonia-lyase complex", "definition": "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. [EC:4.3.1.7]"}
{"concept_id": "C1167447", "aliases": ["excinuclease ABC complex", "excinuclease repair complex location", "excinuclease ABC complex location", "UvrABC excinuclease complex", "UvrABC excinuclease complex location"], "types": ["T026"], "canonical_name": "excinuclease repair complex", "definition": "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap. [GOC:mah, GOC:mlg, PMID:12145219, PMID:15192705]"}
{"concept_id": "C1167448", "aliases": ["exodeoxyribonuclease V complex location"], "types": ["T026"], "canonical_name": "exodeoxyribonuclease V complex", "definition": "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. [EC:3.1.11.5]"}
{"concept_id": "C1167449", "aliases": ["exodeoxyribonuclease VII complex location"], "types": ["T026"], "canonical_name": "exodeoxyribonuclease VII complex", "definition": "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. [EC:3.1.11.6]"}
{"concept_id": "C1167452", "aliases": ["FSH complex location", "follicle stimulating hormone complex location", "follicle-stimulating hormone complex location", "FSH complex", "follicle stimulating hormone complex"], "types": ["T026"], "canonical_name": "follicle-stimulating hormone complex", "definition": "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity. [ISBN:0198547684]"}
{"concept_id": "C1167453", "aliases": ["formate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "formate dehydrogenase complex", "definition": "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2). [PMID:1504073, PMID:8566699]"}
{"concept_id": "C1167454", "aliases": ["glutamate synthase complex location (NADPH)"], "types": ["T026"], "canonical_name": "glutamate synthase complex (NADPH)", "definition": "A complex that possesses glutamate synthase (NADPH) activity. [EC:1.4.1.13, GOC:mah]"}
{"concept_id": "C1167455", "aliases": ["gamma-glutamylcysteine synthetase complex location", "glutamate-cysteine ligase complex location", "gamma-glutamylcysteine synthetase complex"], "types": ["T026"], "canonical_name": "glutamate-cysteine ligase complex", "definition": "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine. [EC:6.3.2.2]"}
{"concept_id": "C1167456", "aliases": ["glutamate-tRNA ligase complex location"], "types": ["T026"], "canonical_name": "glutamate-tRNA ligase complex", "definition": "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu). [EC:6.1.1.17]"}
{"concept_id": "C1167457", "aliases": ["glycerol-3-phosphate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "glycerol-3-phosphate dehydrogenase complex", "definition": "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. [EC:1.1.5.3]"}
{"concept_id": "C1167460", "aliases": ["glycine-tRNA ligase complex location", "glycine-tRNA synthetase complex", "glycine-tRNA synthetase complex location"], "types": ["T026"], "canonical_name": "glycine-tRNA ligase complex", "definition": "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly). [EC:6.1.1.14, GOC:jl, PMID:15733854]"}
{"concept_id": "C1167461", "aliases": ["glycolate oxidase complex location"], "types": ["T026"], "canonical_name": "glycolate oxidase complex", "definition": "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN). [EC:1.1.3.15]"}
{"concept_id": "C1167462", "aliases": ["guanylate cyclase complex location, soluble"], "types": ["T026"], "canonical_name": "guanylate cyclase complex, soluble", "definition": "Complex that possesses guanylate cyclase activity and is not bound to a membrane. [GOC:mah]"}
{"concept_id": "C1167463", "aliases": ["Holliday junction helicase complex location"], "types": ["T026"], "canonical_name": "Holliday junction helicase complex", "definition": "A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA. [PMID:16935884, PMID:9442895]"}
{"concept_id": "C1167464", "aliases": ["holo-[acyl-carrier-protein] synthase complex location"], "types": ["T026"], "canonical_name": "holo-[acyl-carrier-protein] synthase complex", "definition": "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]. [EC:2.7.8.7]"}
{"concept_id": "C1167465", "aliases": ["ClpYQ protease complex location", "ClpYQ protease complex", "HslUV protease complex location"], "types": ["T026"], "canonical_name": "HslUV protease complex", "definition": "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. [GOC:bhm, PMID:12670962, UniProt:P0A6H5]"}
{"concept_id": "C1167466", "aliases": ["hydrogenase complex location"], "types": ["T026"], "canonical_name": "hydrogenase complex"}
{"concept_id": "C1167467", "aliases": ["imidazoleglycerol phosphate synthase complex location", "imidazoleglycerol phosphate synthase complex", "imidazoleglycerol-phosphate synthase complex location"], "types": ["T026"], "canonical_name": "imidazoleglycerol-phosphate synthase complex", "definition": "Complex that possesses imidazoleglycerol-phosphate synthase activity. [GOC:mah]"}
{"concept_id": "C1167468", "aliases": ["magnesium-dependent protein serine/threonine phosphatase complex location"], "types": ["T026"], "canonical_name": "magnesium-dependent protein serine/threonine phosphatase complex", "definition": "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase. [PMID:17517611, PMID:22343722]"}
{"concept_id": "C1167469", "aliases": ["methane monooxygenase complex location"], "types": ["T026"], "canonical_name": "methane monooxygenase complex", "definition": "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized. [BRENDA:1.14.13.25, GOC:mah]"}
{"concept_id": "C1167470", "aliases": ["methionyl glutamyl tRNA synthetase complex location"], "types": ["T026"], "canonical_name": "methionyl glutamyl tRNA synthetase complex", "definition": "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers. [GOC:mcc, PMID:11069915]"}
{"concept_id": "C1167471", "aliases": ["molybdopterin synthase complex location", "molybdopterin converting factor complex", "molybdopterin converting factor complex location"], "types": ["T026"], "canonical_name": "molybdopterin synthase complex", "definition": "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. [GOC:mah, PMID:12571227, PMID:15709772]"}
{"concept_id": "C1167473", "aliases": ["NAD(P)+ transhydrogenase complex location (AB-specific)"], "types": ["T026"], "canonical_name": "NAD(P)+ transhydrogenase complex (AB-specific)", "definition": "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified. [BRENDA:1.6.1.2, GOC:mah]"}
{"concept_id": "C1167475", "aliases": ["nitrate reductase complex location"], "types": ["T026"], "canonical_name": "nitrate reductase complex", "definition": "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. [EC:1.7.99.4]"}
{"concept_id": "C1167476", "aliases": ["nitrite reductase complex location [NAD(P)H]"], "types": ["T026"], "canonical_name": "nitrite reductase complex [NAD(P)H]", "definition": "Complex that possesses nitrite reductase [NAD(P)H] activity. [GOC:mah]"}
{"concept_id": "C1167477", "aliases": ["nitrogenase complex location"], "types": ["T026"], "canonical_name": "nitrogenase complex", "definition": "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen. [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525]"}
{"concept_id": "C1167478", "aliases": ["iron-iron nitrogenase complex location"], "types": ["T026"], "canonical_name": "iron-iron nitrogenase complex", "definition": "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen. [EC:1.18.6.1, GOC:jl, PMID:11848850]"}
{"concept_id": "C1167479", "aliases": ["molybdenum-iron nitrogenase complex location"], "types": ["T026"], "canonical_name": "molybdenum-iron nitrogenase complex", "definition": "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer. [EC:1.18.6.1]"}
{"concept_id": "C1167480", "aliases": ["vanadium-iron nitrogenase complex location"], "types": ["T026"], "canonical_name": "vanadium-iron nitrogenase complex", "definition": "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer. [EC:1.18.6.1, PMID:3474027]"}
{"concept_id": "C1167481", "aliases": ["ornithine carbamoyltransferase complex location"], "types": ["T026"], "canonical_name": "ornithine carbamoyltransferase complex", "definition": "A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. [EC:2.1.3.3, GOC:mah]"}
{"concept_id": "C1167482", "aliases": ["p-aminobenzoate synthetase complex location"], "types": ["T026"], "canonical_name": "p-aminobenzoate synthetase complex"}
{"concept_id": "C1167483", "aliases": ["phenylalanine-tRNA ligase complex location"], "types": ["T026"], "canonical_name": "phenylalanine-tRNA ligase complex", "definition": "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe). [EC:6.1.1.20]"}
{"concept_id": "C1167484", "aliases": ["phosphoribosylaminoimidazole carboxylase complex location"], "types": ["T026"], "canonical_name": "phosphoribosylaminoimidazole carboxylase complex", "definition": "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity. [GOC:mah]"}
{"concept_id": "C1167485", "aliases": ["phosphorylase kinase complex location"], "types": ["T026"], "canonical_name": "phosphorylase kinase complex", "definition": "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. [EC:2.7.11.19]"}
{"concept_id": "C1167486", "aliases": ["photoreceptor cyclic-nucleotide phosphodiesterase complex location"], "types": ["T026"], "canonical_name": "photoreceptor cyclic-nucleotide phosphodiesterase complex"}
{"concept_id": "C1167487", "aliases": ["polyphosphate kinase complex location"], "types": ["T026"], "canonical_name": "polyphosphate kinase complex", "definition": "A protein complex that possesses polyphosphate kinase activity. [GOC:mah]"}
{"concept_id": "C1167489", "aliases": ["procollagen-proline, 2-oxoglutarate-4-dioxygenase complex location", "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex", "procollagen-proline 4-dioxygenase complex location"], "types": ["T026"], "canonical_name": "procollagen-proline 4-dioxygenase complex", "definition": "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase. [PMID:14500733, PMID:7753822]"}
{"concept_id": "C1167490", "aliases": ["protein farnesyltransferase complex location"], "types": ["T026"], "canonical_name": "protein farnesyltransferase complex", "definition": "A protein complex that possesses protein farnesyltransferase activity. [GOC:mah]"}
{"concept_id": "C1167491", "aliases": ["protein histidine kinase complex location"], "types": ["T026"], "canonical_name": "protein histidine kinase complex", "definition": "A complex that possesses protein histidine kinase activity. [GOC:mah]"}
{"concept_id": "C1167492", "aliases": ["casein kinase II complex location", "casein kinase II complex", "protein kinase CK2 complex location"], "types": ["T026"], "canonical_name": "protein kinase CK2 complex", "definition": "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. [GOC:mah, PMID:10994779]"}
{"concept_id": "C1167493", "aliases": ["protein serine/threonine phosphatase complex location"], "types": ["T026"], "canonical_name": "protein serine/threonine phosphatase complex", "definition": "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. [GOC:bf]"}
{"concept_id": "C1167494", "aliases": ["calcium-dependent protein serine/threonine phosphatase complex location"], "types": ["T026"], "canonical_name": "calcium-dependent protein serine/threonine phosphatase complex"}
{"concept_id": "C1167495", "aliases": ["myosin phosphatase complex location"], "types": ["T026"], "canonical_name": "myosin phosphatase complex", "definition": "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. Composed of a PP1 catalytic subunit (PP1c/PPP1CB) and a myosin phosphatase targeting subunit (MYPT1/PPP1R12A). [PMID:30076859]"}
{"concept_id": "C1167496", "aliases": ["protein phosphatase 4 complex location"], "types": ["T026"], "canonical_name": "protein phosphatase 4 complex", "definition": "A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits. [GOC:bhm, PMID:10026142]"}
{"concept_id": "C1167497", "aliases": ["protein phosphatase type 1 complex location"], "types": ["T026"], "canonical_name": "protein phosphatase type 1 complex", "definition": "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. [GOC:mah, GOC:ssd]"}
{"concept_id": "C1167498", "aliases": ["protein phosphatase type 2A complex location", "PP2A complex", "PP2A-pi", "PP2A complex location"], "types": ["T026"], "canonical_name": "protein phosphatase type 2A complex", "definition": "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. [GOC:mah, ISBN:0198547684, PMID:17245430]"}
{"concept_id": "C1167499", "aliases": ["protein-N(PI)-phosphohistidine-sugar phosphotransferase complex location"], "types": ["T026"], "canonical_name": "protein-N(PI)-phosphohistidine-sugar phosphotransferase complex", "definition": "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system. [EC:2.7.1.69]"}
{"concept_id": "C1167502", "aliases": ["Rab-protein geranylgeranyltransferase complex location", "GGTase-II complex", "GGTase-II complex location", "Rab geranylgeranyltransferase complex location", "RabGGTase complex", "RabGGTase complex location", "Rab geranylgeranyltransferase complex"], "types": ["T026"], "canonical_name": "Rab-protein geranylgeranyltransferase complex", "definition": "An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein). [GOC:jl, PMID:11886217]"}
{"concept_id": "C1167503", "aliases": ["riboflavin synthase complex location"], "types": ["T026"], "canonical_name": "riboflavin synthase complex", "definition": "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine. [EC:2.5.1.9]"}
{"concept_id": "C1167504", "aliases": ["ribonucleotide reductase complex", "ribonucleoside-diphosphate reductase complex location", "RNR complex", "ribonucleotide reductase complex location", "RNR complex location"], "types": ["T026"], "canonical_name": "ribonucleoside-diphosphate reductase complex", "definition": "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. [BRENDA:1.17.4.1]"}
{"concept_id": "C1167506", "aliases": ["RISC complex", "RISC complex location", "RNA-induced silencing complex"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. [PMID:10749213, PMID:15145345]", "canonical_name": "RNA-induced silencing complex location"}
{"concept_id": "C1167507", "aliases": ["serine-pyruvate aminotransferase, type 1 complex location"], "types": ["T026"], "canonical_name": "serine-pyruvate aminotransferase, type 1 complex"}
{"concept_id": "C1167508", "aliases": ["serine-pyruvate aminotransferase, type 2B complex location"], "types": ["T026"], "canonical_name": "serine-pyruvate aminotransferase, type 2B complex"}
{"concept_id": "C1167509", "aliases": ["succinyl-CoA synthetase, ADP-forming", "succinate-CoA ligase complex location (ADP-forming)"], "types": ["T026"], "canonical_name": "succinate-CoA ligase complex (ADP-forming)", "definition": "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP. [GOC:jl, PMID:9874242]"}
{"concept_id": "C1167510", "aliases": ["sulphate adenylyltransferase complex location (ATP)", "sulfate adenylyltransferase complex location (ATP)", "sulphate adenylyltransferase complex (ATP)"], "types": ["T026"], "canonical_name": "sulfate adenylyltransferase complex (ATP)", "definition": "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP. [EC:2.7.7.4]"}
{"concept_id": "C1167511", "aliases": ["sulphite reductase complex location (NADPH)", "sulfite reductase complex location (NADPH)", "sulphite reductase complex (NADPH)"], "types": ["T026"], "canonical_name": "sulfite reductase complex (NADPH)", "definition": "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide. [BRENDA:1.8.1.2, GOC:jl]"}
{"concept_id": "C1167512", "aliases": ["translation release factor complex location", "eukaryotic peptide chain release factor"], "types": ["T026"], "canonical_name": "translation release factor complex", "definition": "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome. [ISBN:0198547684]"}
{"concept_id": "C1167513", "aliases": ["trimethylamine-N-oxide reductase complex location"], "types": ["T026"], "canonical_name": "trimethylamine-N-oxide reductase complex", "definition": "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine. [GOC:curators]"}
{"concept_id": "C1167514", "aliases": ["type I site-specific deoxyribonuclease complex location", "type I restriction enzyme complex location", "type I restriction enzyme complex"], "types": ["T026"], "canonical_name": "type I site-specific deoxyribonuclease complex", "definition": "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell. [PMID:12654995, PMID:15788748]"}
{"concept_id": "C1167515", "aliases": ["type II site-specific deoxyribonuclease complex location", "type II restriction enzyme complex location", "type II restriction enzyme complex"], "types": ["T026"], "canonical_name": "type II site-specific deoxyribonuclease complex", "definition": "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell. [PMID:12654995]"}
{"concept_id": "C1167516", "aliases": ["type III site-specific deoxyribonuclease complex location", "type III restriction enzyme complex location", "type III restriction enzyme complex"], "types": ["T026"], "canonical_name": "type III site-specific deoxyribonuclease complex", "definition": "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell. [PMID:12654995]"}
{"concept_id": "C1167517", "aliases": ["UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase", "protein N-acetylglucosaminyltransferase complex location", "O-GlcNAc transferase complex location", "O-GlcNAc transferase complex"], "types": ["T026"], "canonical_name": "protein N-acetylglucosaminyltransferase complex", "definition": "A protein complex capable of protein N-acetylglucosaminyltransferase activity, the addition of nucleotide-activated sugars onto the polypeptide according to reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. The complex has different compositions in different species: In mammals it is often a homotrimer, in bacteria a heterotetramer of 2 different subunits. [PMID:15247246]"}
{"concept_id": "C1167518", "aliases": ["core", "nucleocapsid"], "types": ["T026"], "definition": "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle. [ISBN:0781702534]", "canonical_name": "viral nucleocapsid"}
{"concept_id": "C1167519", "aliases": [], "types": ["T026"], "canonical_name": "viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. [GOC:mtg_sensu, ISBN:0198506732]"}
{"concept_id": "C1167520", "aliases": ["capsomer"], "types": ["T026"], "canonical_name": "capsomere", "definition": "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses. [ISBN:0198506732]"}
{"concept_id": "C1167521", "aliases": [], "types": ["T026"], "canonical_name": "helical viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure. [ISBN:071673706X, UniProtKB-KW:KW-1139, VZ:885]"}
{"concept_id": "C1167522", "aliases": ["quasispherical viral capsid"], "types": ["T026"], "canonical_name": "icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. Tobacco satellite necrosis virus has such a capsid structure. [GOC:bm, ISBN:0198506732, ISBN:071673706X, VZ:885, Wikipedia:Capsid]"}
{"concept_id": "C1167524", "aliases": ["viral portal complex location"], "types": ["T026"], "canonical_name": "viral portal complex", "definition": "A multimeric ring of proteins through which the DNA enters and exits the viral capsid. [PMID:11602732]"}
{"concept_id": "C1167525", "aliases": [], "types": ["T026"], "canonical_name": "viral scaffold", "definition": "A complex of proteins that form a scaffold around which the viral capsid is constructed. [ISBN:0072370319]"}
{"concept_id": "C1167538", "aliases": [], "types": ["T026"], "canonical_name": "viral procapsid", "definition": "A stable empty viral capsid produced during the assembly of viruses. [ISBN:0072370319, ISBN:1555811272]"}
{"concept_id": "C1167539", "aliases": [], "types": ["T026"], "canonical_name": "viral tegument", "definition": "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically. [ISBN:0721662544]"}
{"concept_id": "C1167621", "aliases": ["ethanol breakdown", "ethanol catabolism", "ethanol degradation"], "types": ["T044"], "canonical_name": "ethanol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1167622", "aliases": [], "types": ["T044"], "definition": "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. [GOC:ceb, GOC:mah, ISBN:0198506732]", "canonical_name": "binding"}
{"concept_id": "C1171312", "aliases": ["nephrogenesis"], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]", "canonical_name": "kidney development"}
{"concept_id": "C1171348", "aliases": ["immunological synapse", "supramolecular activation cluster"], "types": ["T026"], "definition": "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [GOC:mgi_curators, PMID:11244041, PMID:11376300]", "canonical_name": "c-SMAC"}
{"concept_id": "C1171356", "aliases": [], "types": ["T040"], "canonical_name": "metacyclogenesis", "definition": "The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania. [PMID:12152483, PMID:21514274, PMID:2659372, PMID:29091711, PMID:29409544]"}
{"concept_id": "C1176286", "aliases": ["cyclosome", "anaphase-promoting complex location", "anaphase-promoting complex", "anaphase promoting complex", "APC"], "types": ["T026"], "definition": "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]", "canonical_name": "anaphase promoting complex location"}
{"concept_id": "C1176301", "aliases": [], "types": ["T045"], "definition": "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts. [GOC:bf, GOC:krc, GOC:mah, PMID:18775984, PMID:27383794, PMID:29681497, PMID:30353673]", "canonical_name": "RNA capping"}
{"concept_id": "C1177283", "aliases": ["taxis"], "types": ["T038"], "definition": "The directed movement of a motile cell or organism in response to an external stimulus. [GOC:jl, ISBN:0192801023]", "canonical_name": "directed movement in response to stimulus"}
{"concept_id": "C1177284", "aliases": [], "types": ["T040"], "definition": "The controlled shedding of a body part. [ISBN:0140514031]", "canonical_name": "abscission"}
{"concept_id": "C1178982", "aliases": [], "types": ["T026"], "definition": "Any of the smaller branches of an axon that emanate from the main axon cylinder. [NIF_Subcellular:sao1470140754]", "canonical_name": "axon collateral"}
{"concept_id": "C1179067", "aliases": ["rod spherule", "rod photoreceptor spherule"], "types": ["T026"], "definition": "A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body. [PMID:26930660]", "canonical_name": "rod cell spherule"}
{"concept_id": "C1179068", "aliases": ["cone cell pedicle"], "types": ["T026"], "definition": "A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL). [PMID:10939333]", "canonical_name": "cone pedicle"}
{"concept_id": "C1179093", "aliases": [], "types": ["T026"], "definition": "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules. [ISBN:0124325653, PMID:9450971]", "canonical_name": "radial spoke"}
{"concept_id": "C1179097", "aliases": ["cilium rootlet", "ciliary rootlet"], "types": ["T026"], "definition": "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm. [GOC:cilia, PMID:12427867]", "canonical_name": "cilial rootlet"}
{"concept_id": "C1179120", "aliases": [], "types": ["T026"], "definition": "A myofilament composed of myosin.", "canonical_name": "thick filament"}
{"concept_id": "C1179121", "aliases": [], "types": ["T026"], "definition": "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils. [ISBN:0815316194]", "canonical_name": "striated muscle thin filament"}
{"concept_id": "C1179122", "aliases": ["T-tubule", "transverse tubule"], "types": ["T026"], "definition": "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. [GOC:mtg_muscle, ISBN:0815316194]", "canonical_name": "triad"}
{"concept_id": "C1179146", "aliases": [], "types": ["T026"], "canonical_name": "triad junction"}
{"concept_id": "C1179490", "aliases": ["Schmidt-Lanterman cleft"], "types": ["T026"], "definition": "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. [GOC:dgh]", "canonical_name": "Schmidt-Lanterman incisure"}
{"concept_id": "C1179626", "aliases": [], "types": ["T024"], "definition": "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). [GOC:dos, PMID:21421911]", "canonical_name": "banded collagen fibril"}
{"concept_id": "C1179869", "aliases": ["Gray's type I synapse"], "types": ["T030"], "definition": "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory. [GOC:dgh, GOC:ef]", "canonical_name": "asymmetric synapse"}
{"concept_id": "C1179874", "aliases": ["synaptic ribbon", "ribbon synapse"], "types": ["T030"], "definition": "Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm. [NIF_Subcellular:sao1884931180, PMID:15626493]", "canonical_name": "synapsis fasciolaris"}
{"concept_id": "C1179878", "aliases": ["cis Golgi network"], "types": ["T026"], "definition": "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. [ISBN:0198506732, ISBN:0815316194]", "canonical_name": "cis-Golgi network"}
{"concept_id": "C1179884", "aliases": [], "types": ["T026"], "definition": "Specialized junctions between NEURONS which connect the cytoplasm of one neuron to another allowing direct passage of an ion current.", "canonical_name": "electrical synapse"}
{"concept_id": "C1179889", "aliases": ["mitochondrial envelope lumen", "mitochondrial membrane lumen"], "types": ["T026"], "definition": "The region between the inner and outer lipid bilayers of the mitochondrial envelope. [GOC:mah]", "canonical_name": "mitochondrial intermembrane space"}
{"concept_id": "C1179890", "aliases": ["Golgi cisterna membrane"], "types": ["T026"], "definition": "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. [GOC:ecd, GOC:mah]", "canonical_name": "Golgi stack membrane"}
{"concept_id": "C1179900", "aliases": [], "types": ["T030"], "definition": "The volume enclosed by the nuclear inner membrane. [GOC:mah, GOC:pz]", "canonical_name": "nuclear lumen"}
{"concept_id": "C1179904", "aliases": ["peroxisome membrane"], "types": ["T026"], "definition": "The lipid bilayer surrounding a peroxisome. [GOC:mah]", "canonical_name": "peroxisomal membrane"}
{"concept_id": "C1179907", "aliases": ["endosomal membrane"], "types": ["T026"], "definition": "The lipid bilayer surrounding an endosome. [GOC:mah]", "canonical_name": "endosome membrane"}
{"concept_id": "C1179919", "aliases": [], "types": ["T026"], "definition": "The volume enclosed by the membrane of an endosome. [GOC:mah]", "canonical_name": "endosome lumen"}
{"concept_id": "C1179931", "aliases": [], "types": ["T026"], "canonical_name": "membrane bound ribosome"}
{"concept_id": "C1179933", "aliases": [], "types": ["T026"], "definition": "A ribosome that is not associated with the membrane of the rough endoplasmic reticulum.", "canonical_name": "free ribosome"}
{"concept_id": "C1179936", "aliases": ["cilial membrane", "cilium membrane"], "types": ["T026"], "definition": "The portion of the plasma membrane surrounding a cilium. [GOC:cilia, GOC:dph, GOC:rph]", "canonical_name": "ciliary membrane"}
{"concept_id": "C1179949", "aliases": ["axonal membrane"], "types": ["T026"], "definition": "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653]", "canonical_name": "axolemma"}
{"concept_id": "C1179956", "aliases": ["lamin filament"], "types": ["T026"], "definition": "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C. [ISBN:0198547684]", "canonical_name": "type V intermediate filament"}
{"concept_id": "C1179972", "aliases": [], "types": ["T026"], "definition": "A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia. [GOC:cilia, GOC:dph, PMID:15882574]", "canonical_name": "kinocilium"}
{"concept_id": "C1179983", "aliases": [], "types": ["T030"], "definition": "The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space. [NIF_Subcellular:sao508958414]", "canonical_name": "mitochondrial intracristal space"}
{"concept_id": "C1179989", "aliases": ["initial segment"], "types": ["T026"], "definition": "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097]", "canonical_name": "axon initial segment"}
{"concept_id": "C1179999", "aliases": ["anchoring junction"], "types": ["T030"], "definition": "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. [ISBN:0815332181]", "canonical_name": "anchoring cell junction"}
{"concept_id": "C1180015", "aliases": [], "types": ["T026"], "definition": "A subcompartment of the smooth endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity. [GOC:sl, PMID:12112448]", "canonical_name": "smooth endoplasmic reticulum cisterna"}
{"concept_id": "C1180016", "aliases": [], "types": ["T026"], "definition": "A subcompartment of the rough endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity. [GOC:sl, PMID:12112448]", "canonical_name": "rough endoplasmic reticulum cisterna"}
{"concept_id": "C1180021", "aliases": ["growing microtubule plus end", "microtubule plus-end"], "types": ["T026"], "definition": "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]", "canonical_name": "microtubule plus end"}
{"concept_id": "C1180022", "aliases": ["microtubule minus end"], "types": ["T026"], "definition": "The end of a microtubule that does not preferentially grow (polymerize). [GOC:lb, PMID:23169647]", "canonical_name": "microtubule minus-end"}
{"concept_id": "C1180038", "aliases": ["cilial tip", "ciliary tip"], "types": ["T026"], "definition": "Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. [GOC:cilia, PMID:23970417]", "canonical_name": "cilium tip"}
{"concept_id": "C1180042", "aliases": ["flagellum shaft", "ciliary shaft", "cilial shaft", "cilium shaft"], "types": ["T026"], "definition": "The mid part of a cilium between the ciliary base and ciliary tip that extends into the extracellular space. [GOC:cilia, GOC:krc, PMID:19866682]", "canonical_name": "flagellar shaft"}
{"concept_id": "C1180045", "aliases": ["cilial basal body", "ciliary basal body", "kinetosome", "microtubule basal body"], "types": ["T026"], "definition": "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. [GOC:cilia, GOC:clt, PMID:21750193]", "canonical_name": "cilium basal body"}
{"concept_id": "C1180047", "aliases": ["cilium axoneme"], "types": ["T026"], "canonical_name": "ciliary axoneme"}
{"concept_id": "C1180051", "aliases": ["flagellum tip"], "types": ["T026"], "canonical_name": "flagellar tip"}
{"concept_id": "C1180063", "aliases": ["flagellum axoneme"], "types": ["T026"], "canonical_name": "flagellar axoneme"}
{"concept_id": "C1180077", "aliases": [], "types": ["T026"], "definition": "A ribosome located in the cytosol. [GOC:mtg_sensu]", "canonical_name": "cytosolic ribosome"}
{"concept_id": "C1180291", "aliases": ["flagellar membrane"], "types": ["T026"], "canonical_name": "flagellum membrane"}
{"concept_id": "C1180298", "aliases": [], "types": ["T026"], "definition": "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. [GOC:cilia, ISBN:0815316194]", "canonical_name": "axonemal microtubule"}
{"concept_id": "C1183489", "aliases": [], "types": ["T026"], "definition": "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. [GOC:dos]", "canonical_name": "cytoplasmic region"}
{"concept_id": "C1183503", "aliases": [], "types": ["T026"], "definition": "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. [GOC:mah, ISBN:0815316194]", "canonical_name": "basal part of cell"}
{"concept_id": "C1186712", "aliases": ["endocytic vesicle membrane"], "types": ["T026"], "definition": "The lipid bilayer surrounding an endocytic vesicle. [GOC:mah]", "canonical_name": "early endosome membrane"}
{"concept_id": "C1186713", "aliases": [], "types": ["T026"], "definition": "The lipid bilayer surrounding a late endosome. [GOC:pz]", "canonical_name": "late endosome membrane"}
{"concept_id": "C1235665", "aliases": [], "types": ["T024"], "definition": "An electron dense layer within the basement membrane.", "canonical_name": "lamina densa"}
{"concept_id": "C1254043", "aliases": [], "types": ["T042"], "definition": "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall). [GOC:isa_complete, GOC:sart]", "canonical_name": "muscle attachment"}
{"concept_id": "C1256369", "aliases": [], "types": ["T043"], "definition": "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. [GOC:mah, ISBN:0198506732]", "canonical_name": "insulin secretion"}
{"concept_id": "C1257756", "aliases": ["RNA catabolism", "RNA breakdown", "RNA degradation"], "types": ["T045"], "definition": "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. [ISBN:0198506732]", "canonical_name": "RNA catabolic process"}
{"concept_id": "C1257758", "aliases": [], "types": ["T045"], "canonical_name": "mRNA decay"}
{"concept_id": "C1257759", "aliases": ["mRNA catabolism", "mRNA catabolic process", "mRNA degradation"], "types": ["T045"], "definition": "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. [ISBN:0198506732]", "canonical_name": "mRNA breakdown"}
{"concept_id": "C1257789", "aliases": ["lymph vessel formation"], "types": ["T039"], "definition": "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. [GOC:dph, PMID:11596157]", "canonical_name": "lymphangiogenesis"}
{"concept_id": "C1257924", "aliases": [], "types": ["T026"], "definition": "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose. [GOC:jl, PMID:11601609, PMID:15197390, PMID:20373916]", "canonical_name": "cellulosome"}
{"concept_id": "C1257985", "aliases": ["cross-priming"], "types": ["T043"], "definition": "Class I-restricted activation of CD8-POSITIVE LYMPHOCYTES resulting from ANTIGEN PRESENTATION of exogenous ANTIGENS (cross-presentation). This is in contrast to normal activation of these lymphocytes (direct-priming) which results from presentation of endogenous antigens.", "canonical_name": "cross priming"}
{"concept_id": "C1257986", "aliases": ["cross-presentation"], "types": ["T043"], "definition": "Transfer of exogenous ANTIGEN to the ANTIGEN-PRESENTING CELLS for presentation to naive CD8-POSITIVE LYMPHOCYTES.", "canonical_name": "cross presentation"}
{"concept_id": "C1258078", "aliases": ["establishment of chromosome localisation", "establishment of chromosome localization"], "types": ["T043"], "definition": "The directed movement of a chromosome to a specific location. [GOC:ai]", "canonical_name": "chromosome positioning"}
{"concept_id": "C1260875", "aliases": [], "types": ["T040"], "definition": "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. [GOC:jl, ISBN:0387520546]", "canonical_name": "mating"}
{"concept_id": "C1261468", "aliases": ["cell fusion", "cell cell fusion"], "types": ["T043"], "definition": "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. [Wikipedia:Cell_fusion]", "canonical_name": "cell-cell fusion"}
{"concept_id": "C1263424", "aliases": ["LANDs"], "types": ["T026"], "definition": "A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies. [PMID:10921892, PMID:8695863]", "canonical_name": "LYSP100-associated nuclear domain"}
{"concept_id": "C1263425", "aliases": [], "types": ["T040"], "definition": "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it. [ISBN:0879015322]", "canonical_name": "dehiscence"}
{"concept_id": "C1265877", "aliases": ["mineralization", "biomineralisation", "mineralisation"], "types": ["T046"], "definition": "The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products. [GOC:aa, PMID:24395694, PMID:28229486]", "canonical_name": "biomineralization"}
{"concept_id": "C1268449", "aliases": [], "types": ["T026"], "canonical_name": "parabasal body"}
{"concept_id": "C1276849", "aliases": ["OGC", "2-oxoglutarate carboxylase activity", "oxalosuccinate synthetase activity"], "types": ["T038"], "definition": "Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H(+) + oxalosuccinate + phosphate. [EC:6.4.1.7, RHEA:20425]", "canonical_name": "CFI"}
{"concept_id": "C1276855", "aliases": [], "types": ["T043"], "definition": "The movement of a monocyte in response to an external stimulus. [GOC:add, PMID:11696603, PMID:15173832]", "canonical_name": "monocyte chemotaxis"}
{"concept_id": "C1291704", "aliases": [], "types": ["T033"], "definition": "The beginning of development of the breasts in the female. [GOC:curators, PMID:19117864]", "canonical_name": "thelarche"}
{"concept_id": "C1299959", "aliases": ["territorial aggression"], "types": ["T055"], "definition": "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics. [GOC:hjd]", "canonical_name": "territorial aggressive behavior"}
{"concept_id": "C1318418", "aliases": [], "types": ["T026"], "definition": "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. [GOC:sl, ISBN:0815316194]", "canonical_name": "brush border"}
{"concept_id": "C1318468", "aliases": [], "types": ["T043"], "canonical_name": "cell-mediated immune response"}
{"concept_id": "C1321502", "aliases": [], "types": ["T044"], "canonical_name": "motor activity"}
{"concept_id": "C1323235", "aliases": ["acyl binding"], "types": ["T044"], "canonical_name": "acyl binding", "definition": "Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. [GOC:curators, ISBN:0198506732]"}
{"concept_id": "C1323236", "aliases": [], "types": ["T044"], "canonical_name": "lipid antigen binding", "definition": "Binding to a lipid antigen. [PMID:14500461]"}
{"concept_id": "C1323237", "aliases": [], "types": ["T044"], "canonical_name": "endogenous lipid antigen binding", "definition": "Binding to an endogenous cellular lipid antigen. [PMID:14500461]"}
{"concept_id": "C1323238", "aliases": [], "types": ["T044"], "canonical_name": "exogenous lipid antigen binding", "definition": "Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids). [PMID:14500461]"}
{"concept_id": "C1323239", "aliases": [], "types": ["T044"], "canonical_name": "peptide antigen binding", "definition": "Binding to an antigen peptide. [GOC:add, GOC:jl, GOC:rv]"}
{"concept_id": "C1323240", "aliases": [], "types": ["T044"], "canonical_name": "endogenous peptide antigen binding"}
{"concept_id": "C1323241", "aliases": [], "types": ["T044"], "canonical_name": "exogenous peptide antigen binding"}
{"concept_id": "C1323242", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan binding", "definition": "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. [GOC:go_curators, PMID:14698226]"}
{"concept_id": "C1323243", "aliases": [], "types": ["T044"], "canonical_name": "calcium oxalate binding", "definition": "Binding to calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi. [ISBN:0721662544]"}
{"concept_id": "C1323244", "aliases": [], "types": ["T044"], "canonical_name": "galacturonan binding", "definition": "Binding to a simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins. [GOC:jid]"}
{"concept_id": "C1323245", "aliases": [], "types": ["T044"], "canonical_name": "disaccharide binding", "definition": "Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units. [GOC:jid]"}
{"concept_id": "C1323246", "aliases": [], "types": ["T044"], "canonical_name": "monosaccharide binding", "definition": "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. [GOC:jid]"}
{"concept_id": "C1323247", "aliases": [], "types": ["T044"], "canonical_name": "fucose binding", "definition": "Binding to fucose, the pentose 6-deoxygalactose. [ISBN:0582227089]"}
{"concept_id": "C1323248", "aliases": ["galacturonic acid binding"], "types": ["T044"], "canonical_name": "galacturonate binding", "definition": "Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. [GOC:jid]"}
{"concept_id": "C1323249", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylgalactosamine binding", "definition": "Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine. [GOC:ai, PMID:18384150]"}
{"concept_id": "C1323250", "aliases": [], "types": ["T044"], "canonical_name": "trisaccharide binding", "definition": "Binding to a trisaccharide. Trisaccharides are sugars composed of three monosaccharide units. [GOC:jid]"}
{"concept_id": "C1323253", "aliases": ["flavine-adenine dinucleotide binding", "FAD or FADH2 binding"], "types": ["T044"], "canonical_name": "flavin adenine dinucleotide binding", "definition": "Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]"}
{"concept_id": "C1323254", "aliases": ["flavin mononucleotide binding"], "types": ["T044"], "canonical_name": "FMN binding", "definition": "Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:tb]"}
{"concept_id": "C1323255", "aliases": ["nicotinamide adenine dinucleotide phosphate binding"], "types": ["T044"], "definition": "Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai]", "canonical_name": "NADP binding"}
{"concept_id": "C1323256", "aliases": [], "types": ["T044"], "canonical_name": "quinone binding", "definition": "Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. [ISBN:0198506732]"}
{"concept_id": "C1323257", "aliases": ["coenzyme Q binding"], "types": ["T044"], "canonical_name": "ubiquinone binding", "definition": "Binding to ubiquinone, a quinone derivative with a tail of isoprene units. [GOC:jid, ISBN:0582227089]"}
{"concept_id": "C1323258", "aliases": ["Valium binding"], "types": ["T044"], "canonical_name": "diazepam binding", "definition": "Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium. [ISBN:0198506732]"}
{"concept_id": "C1323259", "aliases": [], "types": ["T044"], "canonical_name": "N-1-naphthylphthalamic acid binding", "definition": "Binding to N-1-naphthylphthalamic acid, an auxin transport inhibitor. [GOC:sm]"}
{"concept_id": "C1323260", "aliases": ["extracellular matrix constituent binding"], "types": ["T044"], "canonical_name": "extracellular matrix binding", "definition": "Binding to a component of the extracellular matrix. [GOC:ai]"}
{"concept_id": "C1323261", "aliases": [], "types": ["T044"], "definition": "Binding to auxin, a plant hormone that regulates aspects of plant growth. [GOC:sm]", "canonical_name": "auxin binding"}
{"concept_id": "C1323262", "aliases": ["ETH receptor"], "types": ["T044"], "canonical_name": "ecdysis-triggering hormone receptor activity", "definition": "Combining with ecdysis-triggering hormone to initiate a change in cell activity. [GOC:ma]"}
{"concept_id": "C1323263", "aliases": [], "types": ["T044"], "canonical_name": "ecdysone binding", "definition": "Binding to 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting. [GOC:bf, ISBN:0198506732, ISBN:0582227089]"}
{"concept_id": "C1323264", "aliases": ["hydroxylapatite binding"], "types": ["T044"], "canonical_name": "hydroxyapatite binding", "definition": "Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin. [PMID:2438276]"}
{"concept_id": "C1323265", "aliases": [], "types": ["T044"], "canonical_name": "3,4-didehydroretinal binding", "definition": "Binding to 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod). [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1323266", "aliases": ["eicosanoid binding"], "types": ["T044"], "canonical_name": "icosanoid binding", "definition": "Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids. [ISBN:0198506732]"}
{"concept_id": "C1323267", "aliases": ["eicosatetraenoic acid binding"], "types": ["T044"], "canonical_name": "icosatetraenoic acid binding", "definition": "Binding to icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule. [ISBN:0198506732]"}
{"concept_id": "C1323268", "aliases": ["5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding"], "types": ["T044"], "canonical_name": "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "definition": "Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. [GOC:ai]"}
{"concept_id": "C1323269", "aliases": ["5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding"], "types": ["T044"], "canonical_name": "5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "definition": "Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. [GOC:ai]"}
{"concept_id": "C1323270", "aliases": ["5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding"], "types": ["T044"], "canonical_name": "5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "definition": "Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. [GOC:ai]"}
{"concept_id": "C1323271", "aliases": ["arachidonate binding"], "types": ["T044"], "canonical_name": "arachidonic acid binding", "definition": "Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [GOC:ai]"}
{"concept_id": "C1323272", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylserine binding", "definition": "Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. [ISBN:0198506732, PMID:12000961]"}
{"concept_id": "C1323274", "aliases": ["metal binding"], "types": ["T044"], "definition": "Binding to a metal ion. [GOC:ai]", "canonical_name": "metal ion binding"}
{"concept_id": "C1323275", "aliases": [], "types": ["T044"], "canonical_name": "transition metal ion binding", "definition": "Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [ISBN:0198506732]"}
{"concept_id": "C1323276", "aliases": ["cadmium binding", "Cd ion binding"], "types": ["T044"], "canonical_name": "cadmium ion binding", "definition": "Binding to a cadmium ion (Cd). [GOC:ai]"}
{"concept_id": "C1323277", "aliases": ["cobalt binding", "Co ion binding"], "types": ["T044"], "canonical_name": "cobalt ion binding", "definition": "Binding to a cobalt ion (Co). [GOC:ai]"}
{"concept_id": "C1323278", "aliases": [], "types": ["T044"], "canonical_name": "microfibril binding", "definition": "Binding to a microfibril, any small fibril occurring in biological material. [GOC:ai]"}
{"concept_id": "C1323280", "aliases": ["telomeric ssDNA binding"], "types": ["T045"], "canonical_name": "single-stranded telomeric DNA binding", "definition": "Binding to single-stranded telomere-associated DNA. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1323281", "aliases": [], "types": ["T045"], "canonical_name": "5S rRNA binding", "definition": "Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1323282", "aliases": [], "types": ["T045"], "canonical_name": "5S rRNA primary transcript binding", "definition": "Binding to an unprocessed 5S ribosomal RNA transcript. [GOC:jl]"}
{"concept_id": "C1323283", "aliases": [], "types": ["T045"], "canonical_name": "BRE binding", "definition": "Binding to a BRE RNA element (Bruno response element). [PMID:10893231]"}
{"concept_id": "C1323284", "aliases": ["mRNA 5' UTR binding"], "types": ["T045"], "canonical_name": "mRNA 5'-UTR binding", "definition": "Binding to an mRNA molecule at its 5' untranslated region. [GOC:jid]"}
{"concept_id": "C1323285", "aliases": ["pre-mRNA 3' splice site binding"], "types": ["T045"], "canonical_name": "pre-mRNA 3'-splice site binding", "definition": "Binding to a pre-mRNA 3' splice site sequence. [GOC:jl]"}
{"concept_id": "C1323286", "aliases": ["pre-mRNA 5' splice site binding"], "types": ["T045"], "canonical_name": "pre-mRNA 5'-splice site binding", "definition": "Binding to a pre-mRNA 5' splice site sequence. [GOC:jl]"}
{"concept_id": "C1323287", "aliases": [], "types": ["T045"], "canonical_name": "pre-mRNA branch point binding", "definition": "Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site. [PMID:11691992, PMID:9722632]"}
{"concept_id": "C1323288", "aliases": ["adenosine 3'-phosphate 5'-phosphosulfate binding", "3'-phosphoadenylyl-sulfate binding", "phosphoadenosine phosphosulfate binding", "3'-phosphoadenosine 5'-phosphosulphate binding", "PAPS binding"], "types": ["T044"], "canonical_name": "3'-phosphoadenosine 5'-phosphosulfate binding", "definition": "Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [GOC:ai]"}
{"concept_id": "C1323289", "aliases": [], "types": ["T044"], "canonical_name": "adenyl-nucleotide exchange factor activity", "definition": "Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. [GOC:kd]"}
{"concept_id": "C1323290", "aliases": [], "types": ["T044"], "canonical_name": "neuropeptide binding", "definition": "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]"}
{"concept_id": "C1323291", "aliases": ["NMU binding"], "types": ["T044"], "canonical_name": "neuromedin U binding", "definition": "Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses. [GOC:jl, PMID:12584108]"}
{"concept_id": "C1323292", "aliases": [], "types": ["T044"], "canonical_name": "myosuppressin receptor activity", "definition": "Combining with the peptide myosuppressin to initiate a change in cell activity. [GOC:bf]"}
{"concept_id": "C1323293", "aliases": [], "types": ["T044"], "definition": "Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. [GOC:ai]", "canonical_name": "signal sequence binding"}
{"concept_id": "C1323294", "aliases": ["endoplasmic reticulum retention sequence binding"], "types": ["T044"], "canonical_name": "ER retention sequence binding", "definition": "Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. [GOC:ai]"}
{"concept_id": "C1323295", "aliases": [], "types": ["T044"], "canonical_name": "vacuolar sorting signal binding", "definition": "Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole. [GOC:mah]"}
{"concept_id": "C1323296", "aliases": ["capZ binding", "beta-actinin binding"], "types": ["T044"], "canonical_name": "actinin binding", "definition": "Binding to actinin, any member of a family of proteins that crosslink F-actin. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1323297", "aliases": [], "types": ["T044"], "canonical_name": "activin binding", "definition": "Binding to activin, a dimer of inhibin-beta subunits. [GOC:jid, GOC:mah]"}
{"concept_id": "C1323298", "aliases": [], "types": ["T044"], "canonical_name": "inhibin beta-A binding"}
{"concept_id": "C1323299", "aliases": [], "types": ["T044"], "canonical_name": "inhibin beta-B binding"}
{"concept_id": "C1323300", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent protein binding", "definition": "Binding to a protein or protein complex using energy from ATP hydrolysis. [GOC:jl]"}
{"concept_id": "C1323301", "aliases": [], "types": ["T044"], "canonical_name": "beta-2-microglobulin binding", "definition": "Binding to beta-2-microglobulin. [GOC:mah]"}
{"concept_id": "C1323303", "aliases": ["TGFbeta binding", "TGF-beta binding"], "types": ["T044"], "canonical_name": "transforming growth factor beta binding", "definition": "Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. [ISBN:0198506732]"}
{"concept_id": "C1323304", "aliases": ["tumor necrosis factor binding"], "types": ["T044"], "definition": "Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. [GOC:jl, http://lookwayup.com/]", "canonical_name": "tumor necrosis factor"}
{"concept_id": "C1323306", "aliases": ["alpha tubulin binding"], "types": ["T044"], "canonical_name": "alpha-tubulin binding", "definition": "Binding to the microtubule constituent protein alpha-tubulin. [GOC:jl]"}
{"concept_id": "C1323307", "aliases": ["gamma tubulin binding"], "types": ["T044"], "canonical_name": "gamma-tubulin binding", "definition": "Binding to the microtubule constituent protein gamma-tubulin. [GOC:jl]"}
{"concept_id": "C1323308", "aliases": [], "types": ["T044"], "canonical_name": "GTP cyclohydrolase I binding"}
{"concept_id": "C1323309", "aliases": ["histone acetylase binding"], "types": ["T044"], "canonical_name": "histone acetyltransferase binding", "definition": "Binding to an histone acetyltransferase. [GOC:bf]"}
{"concept_id": "C1323310", "aliases": [], "types": ["T044"], "canonical_name": "histone deacetylase binding", "definition": "Binding to histone deacetylase. [GOC:jl]"}
{"concept_id": "C1323311", "aliases": ["MAPK p38 binding"], "types": ["T044"], "canonical_name": "mitogen-activated protein kinase p38 binding", "definition": "Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. [GOC:curators, PMID:17827184]"}
{"concept_id": "C1323315", "aliases": ["neurotrophin binding", "NT-4/5 binding", "neurotrophin-4/5 binding", "neurotrophic factor binding", "neurotrophin 4/5 binding", "neurotrophin"], "types": ["T044"], "definition": "Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. [GOC:jl]", "canonical_name": "NT 4/5 binding"}
{"concept_id": "C1323316", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin receptor activity", "definition": "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]"}
{"concept_id": "C1323317", "aliases": [], "types": ["T044"], "canonical_name": "GTP-dependent protein binding", "definition": "Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state. [GOC:go_curators, GOC:krc]"}
{"concept_id": "C1323318", "aliases": [], "types": ["T044"], "canonical_name": "methylated histone binding", "definition": "Binding to a histone in which a residue has been modified by methylation. [GOC:bf, PMID:14585615]"}
{"concept_id": "C1323319", "aliases": [], "types": ["T044"], "canonical_name": "IgM binding", "definition": "Binding to an immunoglobulin of the IgM isotype. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1323320", "aliases": [], "types": ["T044"], "canonical_name": "IgM receptor activity", "definition": "Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1323321", "aliases": [], "types": ["T044"], "canonical_name": "polymeric immunoglobulin receptor activity", "definition": "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1323322", "aliases": [], "types": ["T044"], "canonical_name": "polymeric immunoglobulin binding", "definition": "Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1323323", "aliases": [], "types": ["T044"], "canonical_name": "phosphoserine binding"}
{"concept_id": "C1323324", "aliases": [], "types": ["T044"], "canonical_name": "phosphothreonine binding"}
{"concept_id": "C1323325", "aliases": [], "types": ["T044"], "canonical_name": "phosphotyrosine binding"}
{"concept_id": "C1323326", "aliases": ["protein binding, bridging"], "types": ["T044"], "canonical_name": "protein-macromolecule adaptor activity", "definition": "The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]"}
{"concept_id": "C1323327", "aliases": [], "types": ["T044"], "canonical_name": "protein dimerization activity", "definition": "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. [ISBN:0198506732]"}
{"concept_id": "C1323328", "aliases": [], "types": ["T044"], "canonical_name": "protein heterodimerization activity", "definition": "Binding to a nonidentical protein to form a heterodimer. [GOC:ai]"}
{"concept_id": "C1323329", "aliases": [], "types": ["T044"], "canonical_name": "dimerization activity"}
{"concept_id": "C1323330", "aliases": [], "types": ["T044"], "canonical_name": "AF-1 domain binding", "definition": "Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor. [PMID:9682036]"}
{"concept_id": "C1323331", "aliases": [], "types": ["T044"], "canonical_name": "AF-2 domain binding", "definition": "Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. [PMID:9682036]"}
{"concept_id": "C1323332", "aliases": [], "types": ["T044"], "canonical_name": "CARD domain binding", "definition": "Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. [PMID:12054670]"}
{"concept_id": "C1323333", "aliases": ["DBD binding"], "types": ["T044"], "canonical_name": "DNA binding domain binding", "definition": "Binding to a protein's DNA binding domain (DBD). [PMID:9682036]"}
{"concept_id": "C1323334", "aliases": ["ligand binding domain binding"], "types": ["T044"], "canonical_name": "LBD domain binding", "definition": "Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. [PMID:9682036]"}
{"concept_id": "C1323335", "aliases": [], "types": ["T044"], "canonical_name": "PH domain binding", "definition": "Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. [GOC:jl, Pfam:PF00169]"}
{"concept_id": "C1323336", "aliases": [], "types": ["T044"], "canonical_name": "RS domain binding", "definition": "Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. [PMID:11684676, PMID:12215544]"}
{"concept_id": "C1323337", "aliases": [], "types": ["T044"], "canonical_name": "WW domain binding", "definition": "Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. [PMID:14531730]"}
{"concept_id": "C1323338", "aliases": ["N-terminal end binding", "N-terminal binding"], "types": ["T044"], "canonical_name": "protein N-terminus binding", "definition": "Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. [ISBN:0198506732]"}
{"concept_id": "C1323339", "aliases": [], "types": ["T044"], "canonical_name": "protein homopolymerization"}
{"concept_id": "C1323340", "aliases": [], "types": ["T044"], "canonical_name": "protein homooligomerization activity", "definition": "OBSOLETE. Interacting selectively with identical proteins to form a homooligomer. [GOC:jl]"}
{"concept_id": "C1323341", "aliases": [], "types": ["T044"], "canonical_name": "S100 alpha binding"}
{"concept_id": "C1323342", "aliases": [], "types": ["T044"], "canonical_name": "S100 beta binding"}
{"concept_id": "C1323343", "aliases": [], "types": ["T044"], "canonical_name": "syntaxin-6 binding"}
{"concept_id": "C1323344", "aliases": [], "types": ["T044"], "canonical_name": "TAP binding", "definition": "Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2. [PMID:11133832]"}
{"concept_id": "C1323345", "aliases": [], "types": ["T044"], "canonical_name": "TAP1 binding", "definition": "Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein. [PMID:11133832]"}
{"concept_id": "C1323346", "aliases": [], "types": ["T044"], "canonical_name": "TAP2 binding", "definition": "Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein. [PMID:11133832]"}
{"concept_id": "C1323347", "aliases": ["TAP binding protein binding"], "types": ["T044"], "canonical_name": "tapasin binding", "definition": "Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules. [PMID:12594855]"}
{"concept_id": "C1323348", "aliases": [], "types": ["T044"], "canonical_name": "tau protein binding", "definition": "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]"}
{"concept_id": "C1323349", "aliases": ["X11L binding"], "types": ["T044"], "canonical_name": "X11-like protein binding", "definition": "Binding to X11-like protein, a neuron-specific adaptor protein. [GOC:jl, PMID:12780348]"}
{"concept_id": "C1323350", "aliases": ["androgen receptor binding", "AR binding"], "types": ["T044"], "canonical_name": "nuclear androgen receptor binding", "definition": "Binding to a nuclear androgen receptor. [GOC:ai]"}
{"concept_id": "C1323351", "aliases": [], "types": ["T044"], "canonical_name": "apolipoprotein E receptor binding", "definition": "OBSOLETE. Interacting selectively with an apolipoprotein E receptor. [GOC:ai]"}
{"concept_id": "C1323352", "aliases": ["CD40L binding"], "types": ["T044"], "canonical_name": "CD154 receptor binding", "definition": "Binding to CD154, a receptor found on the surface of some activated lymphocytes. [GOC:jl, ISBN:0120781859]"}
{"concept_id": "C1323353", "aliases": [], "types": ["T044"], "canonical_name": "CD4 receptor binding", "definition": "Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages. [GOC:jl, MSH:D015704]"}
{"concept_id": "C1323354", "aliases": ["CD27L binding"], "types": ["T044"], "canonical_name": "CD70 receptor binding", "definition": "Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells. [GOC:jl, ISBN:0120781859]"}
{"concept_id": "C1323355", "aliases": [], "types": ["T044"], "canonical_name": "CD8 receptor binding", "definition": "Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. [GOC:jl, MSH:D016827]"}
{"concept_id": "C1323356", "aliases": [], "types": ["T044"], "canonical_name": "CD27 receptor binding", "definition": "Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells. [GOC:jl, ISBN:0120781859]"}
{"concept_id": "C1323357", "aliases": [], "types": ["T044"], "canonical_name": "CD40 receptor binding", "definition": "Binding to CD40, a receptor found on the surface of all B-lymphocytes. [GOC:jl, ISBN:0120781859]"}
{"concept_id": "C1323358", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin TRK receptor ligand"}
{"concept_id": "C1323359", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin TRKA receptor binding", "definition": "Binding to a neurotrophin TRKA receptor. [GOC:ai]"}
{"concept_id": "C1323360", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin TRKB receptor ligand"}
{"concept_id": "C1323361", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin TRKC receptor ligand"}
{"concept_id": "C1323362", "aliases": ["platelet-derived growth factor", "PDGFR binding", "PDGF receptor binding", "PDGF"], "types": ["T044"], "definition": "Binding to a platelet-derived growth factor receptor. [GOC:ai]", "canonical_name": "platelet-derived growth factor receptor binding"}
{"concept_id": "C1323363", "aliases": ["TNF receptor binding"], "types": ["T044"], "definition": "Binding to a tumor necrosis factor receptor. [GOC:ai]", "canonical_name": "tumor necrosis factor receptor binding"}
{"concept_id": "C1323364", "aliases": ["vascular endothelial growth factor receptor binding", "VEGF receptor binding"], "types": ["T044"], "definition": "Binding to a vascular endothelial growth factor receptor. [GOC:ai]", "canonical_name": "VEGFR binding"}
{"concept_id": "C1323365", "aliases": [], "types": ["T044"], "canonical_name": "dopamine receptor binding", "definition": "Binding to a dopamine receptor. [GOC:ai]"}
{"concept_id": "C1323366", "aliases": ["ephrin receptor binding", "Eph receptor binding"], "types": ["T044"], "definition": "Binding to an ephrin receptor. [GOC:ai]", "canonical_name": "ephrin"}
{"concept_id": "C1323367", "aliases": ["TGF-alpha receptor binding", "EGF receptor binding", "epidermal growth factor receptor binding", "TGFalpha receptor binding", "EGFR binding", "transforming growth factor alpha receptor binding", "EGF"], "types": ["T044"], "definition": "Binding to an epidermal growth factor receptor. [GOC:ai]", "canonical_name": "epidermal growth factor"}
{"concept_id": "C1323368", "aliases": [], "types": ["T044"], "canonical_name": "CXCR3 chemokine receptor binding", "definition": "Binding to a CXCR3 chemokine receptor. [GOC:jid, PMID:10556837]"}
{"concept_id": "C1323370", "aliases": [], "types": ["T044"], "canonical_name": "glial cell line-derived neurotrophic factor receptor ligand"}
{"concept_id": "C1323371", "aliases": ["LDL receptor binding", "low-density lipoprotein receptor binding"], "types": ["T044"], "canonical_name": "low-density lipoprotein particle receptor binding", "definition": "Binding to a low-density lipoprotein receptor. [GOC:ai]"}
{"concept_id": "C1323372", "aliases": ["major histocompatibility complex class I binding"], "types": ["T044"], "canonical_name": "MHC class I protein binding", "definition": "Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]"}
{"concept_id": "C1323373", "aliases": ["major histocompatibility complex class II binding"], "types": ["T044"], "canonical_name": "MHC class II protein binding", "definition": "Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]"}
{"concept_id": "C1323374", "aliases": ["major histocompatibility complex class II protein binding, via antigen binding groove"], "types": ["T044"], "canonical_name": "MHC class II protein binding, via antigen binding groove", "definition": "Binding to the antigen binding groove of major histocompatibility complex class II molecules. [GOC:jl]"}
{"concept_id": "C1323375", "aliases": ["major histocompatibility complex class II protein binding, via lateral surface"], "types": ["T044"], "canonical_name": "MHC class II protein binding, via lateral surface", "definition": "Binding to the lateral surface of major histocompatibility complex class II molecules. [GOC:jl]"}
{"concept_id": "C1323376", "aliases": [], "types": ["T044"], "canonical_name": "neuromedin U receptor binding", "definition": "Binding to one or more specific sites on a neuromedin U receptor. [GOC:jl, PMID:10899166]"}
{"concept_id": "C1323377", "aliases": ["PPAR binding"], "types": ["T044"], "canonical_name": "peroxisome proliferator activated receptor binding", "definition": "Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma. [GOC:jl, PMID:12769781]"}
{"concept_id": "C1323378", "aliases": [], "types": ["T044"], "canonical_name": "mating pheromone activity", "definition": "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted. [GOC:clt, GOC:elh]"}
{"concept_id": "C1323379", "aliases": ["advanced glycation end-product receptor binding"], "types": ["T044"], "canonical_name": "RAGE receptor binding", "definition": "Binding to a RAGE receptor, the receptor for advanced glycation end-products. [GOC:ai]"}
{"concept_id": "C1323380", "aliases": [], "types": ["T044"], "canonical_name": "chemokine receptor antagonist activity", "definition": "Interacts with chemokine receptors to reduce the action of a chemokine. [GOC:ai, ISBN:0781718325]"}
{"concept_id": "C1323381", "aliases": ["retinoic acid receptor binding", "RAR binding"], "types": ["T044"], "canonical_name": "nuclear retinoic acid receptor binding", "definition": "Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. [GOC:jl, PMID:12476796]"}
{"concept_id": "C1323382", "aliases": ["retinoid X receptor binding", "RXR binding"], "types": ["T044"], "canonical_name": "nuclear retinoid X receptor binding", "definition": "Binding to a nuclear retinoid X receptor. [GOC:ai]"}
{"concept_id": "C1323383", "aliases": ["TCR binding", "T lymphocyte receptor binding", "T-cell receptor binding", "T-lymphocyte receptor binding"], "types": ["T044"], "canonical_name": "T cell receptor binding", "definition": "Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. [GOC:jl]"}
{"concept_id": "C1323384", "aliases": [], "types": ["T044"], "canonical_name": "thyroid hormone receptor binding"}
{"concept_id": "C1323385", "aliases": ["toxin receptor binding"], "types": ["T044"], "definition": "Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom. [GOC:pt]", "canonical_name": "toxin activity"}
{"concept_id": "C1323386", "aliases": ["transforming growth factor beta receptor binding", "TGF-beta receptor binding"], "types": ["T044"], "definition": "Binding to a transforming growth factor beta receptor. [GOC:ai]", "canonical_name": "TGFbeta receptor binding"}
{"concept_id": "C1323387", "aliases": ["vitamin D receptor binding", "VDR binding", "calciferol receptor binding"], "types": ["T044"], "canonical_name": "nuclear vitamin D receptor binding", "definition": "Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. [GOC:jl, PMID:12637589]"}
{"concept_id": "C1323388", "aliases": ["RNP binding", "protein-RNA complex binding", "ribonucleoprotein binding"], "types": ["T044"], "canonical_name": "ribonucleoprotein complex binding", "definition": "Binding to a complex of RNA and protein. [GOC:bf, GOC:go_curators, GOC:vk]"}
{"concept_id": "C1323389", "aliases": [], "types": ["T044"], "canonical_name": "ribosomal large subunit binding", "definition": "Binding to a large ribosomal subunit. [GOC:go_curators]"}
{"concept_id": "C1323390", "aliases": [], "types": ["T044"], "canonical_name": "ribosomal small subunit binding", "definition": "Binding to a small ribosomal subunit. [GOC:go_curators]"}
{"concept_id": "C1323391", "aliases": [], "types": ["T044"], "canonical_name": "ribosome binding", "definition": "Binding to a ribosome. [GOC:go_curators]"}
{"concept_id": "C1323392", "aliases": [], "types": ["T044"], "canonical_name": "tetrapyrrole binding", "definition": "Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. [GOC:curators, ISBN:0198506732]"}
{"concept_id": "C1323394", "aliases": ["ice crystal binding"], "types": ["T044"], "canonical_name": "ice binding", "definition": "Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. [GOC:curators]"}
{"concept_id": "C1323395", "aliases": [], "types": ["T044"], "canonical_name": "adenylate forming enzyme activity", "definition": "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate. [PMID:12084835]"}
{"concept_id": "C1323396", "aliases": [], "types": ["T044"], "canonical_name": "cyclase activity", "definition": "Catalysis of a ring closure reaction. [ISBN:0198547684]"}
{"concept_id": "C1323397", "aliases": [], "types": ["T044"], "canonical_name": "tocopherol cyclase activity", "definition": "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol). [PMID:12213958]"}
{"concept_id": "C1323398", "aliases": ["D1-pyrroline-5-carboxylate synthetase activity"], "types": ["T044"], "canonical_name": "delta1-pyrroline-5-carboxylate synthetase activity", "definition": "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate. [MetaCyc:PROLINE-MULTI]"}
{"concept_id": "C1323399", "aliases": ["D-lactate dehydratase", "(R)-lactate hydro-lyase"], "types": ["T044"], "canonical_name": "glyoxalase III activity", "definition": "Catalysis of the reaction: methylglyoxal + H2O = D-lactate. [GOC:mcc, PMID:21696459, PMID:7848303, RHEA:27754]"}
{"concept_id": "C1323400", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement", "definition": "OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance. [EC:3.6.5.-, GOC:ai]"}
{"concept_id": "C1323401", "aliases": ["ATP-dependent transmembrane transporter activity", "ATPase activity, coupled to transmembrane movement of substances", "ATP-coupled transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled transmembrane transporter activity", "definition": "Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1323402", "aliases": ["antimonite-transporting ATPase activity", "ATP-dependent antimonite transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled antimonite transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out). [EC:7.3.2.7]"}
{"concept_id": "C1323403", "aliases": [], "types": ["T044"], "canonical_name": "D-ribose-importing ATPase activity"}
{"concept_id": "C1323404", "aliases": [], "types": ["T044"], "canonical_name": "D-xylose-importing ATPase activity"}
{"concept_id": "C1323405", "aliases": ["L-arabinose porter activity", "L-arabinose-importing ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type L-arabinose transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in). [RHEA:30007]"}
{"concept_id": "C1323407", "aliases": ["phosphonate transporting ATPase activity", "organic phosphonate transmembrane-transporting ATPase activity", "ATP phosphohydrolase (phosphonate-transporting)", "phosphonate-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled organic phosphonate transmembrane transporter activity"}
{"concept_id": "C1323408", "aliases": ["ATPase activity, coupled to transmembrane movement of ions", "ATPase coupled ion transmembrane transporter activity", "ATP-dependent ion transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled ion transmembrane transporter activity", "definition": "Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1323409", "aliases": ["proton-exporting ATPase activity, phosphorylative mechanism", "proton-translocating ATPase activity", "H+-exporting ATPase activity", "proton transport ATPase activity", "hydrogen exporting ATPase activity, phosphorylative mechanism", "proton-transporting ATPase activity", "hydrogen-exporting ATPase activity, phosphorylative mechanism"], "types": ["T044"], "canonical_name": "P-type proton-exporting transporter activity", "definition": "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle. [RHEA:20852]"}
{"concept_id": "C1323410", "aliases": ["Na(+)-transporting ATPase activity", "Na+-exporting ATPase activity", "Na(+)-exporting ATPase activity", "Na+-transporting ATPase activity"], "types": ["T044"], "canonical_name": "sodium-exporting ATPase activity"}
{"concept_id": "C1323411", "aliases": ["hydrogen ion transporting ATPase activity, rotational mechanism", "H+-transporting ATPase activity", "H(+)-transporting ATP synthase activity", "proton-transporting ATPase activity, rotational mechanism", "H(+)-transporting ATPase activity", "hydrogen ion transporting two-sector ATPase activity", "hydrogen ion translocating F-type ATPase activity"], "types": ["T044"], "definition": "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. [RHEA:57721]", "canonical_name": "ATP phosphohydrolase (H+-transporting) activity"}
{"concept_id": "C1323412", "aliases": ["ATP synthase, sodium ion specific activity", "Na(+)-transporting two-sector ATPase activity", "ATP phosphohydrolase (Na+-transporting) activity", "Na(+)-translocating ATPase activity", "Na+-translocating ATPase activity", "sodium transporting ATPase activity, rotational mechanism"], "types": ["T044"], "canonical_name": "sodium-transporting ATPase activity, rotational mechanism", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism. [PMID:30791207, RHEA:58157]"}
{"concept_id": "C1323413", "aliases": ["5'-acylphosphoadenosine acylhydrolase activity", "5-phosphoadenosine hydrolase activity"], "types": ["T044"], "canonical_name": "5'-acylphosphoadenosine hydrolase activity", "definition": "Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate. [EC:3.6.1.20, MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN]"}
{"concept_id": "C1323414", "aliases": ["adenosine-tetraphosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "adenosine-tetraphosphatase activity", "definition": "Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate. [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN]"}
{"concept_id": "C1323415", "aliases": ["adenosine diphosphoribose pyrophosphatase activity", "ADP-ribose ribophosphohydrolase activity", "ADP-ribose pyrophosphatase activity", "ADPribose diphosphatase activity", "ADPR-PPase activity", "ADP-ribose phosphohydrolase activity", "ADPribose pyrophosphatase activity"], "types": ["T044"], "canonical_name": "ADP-ribose diphosphatase activity", "definition": "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN]"}
{"concept_id": "C1323416", "aliases": ["adenosine triphosphate pyrophosphatase activity", "ATP diphosphohydrolase", "ATP pyrophosphatase activity", "ATP diphosphohydrolase (diphosphate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + H2O = AMP + diphosphate. [RHEA:14245]", "canonical_name": "ATP diphosphatase activity"}
{"concept_id": "C1323419", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent ATPase activity", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+). [GOC:mah]"}
{"concept_id": "C1323421", "aliases": ["diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity", "1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity", "P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity", "diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity", "diadenosine 5,5-P1,P3-triphosphatase activity", "dinucleosidetriphosphatase activity", "AP3A hydrolase activity", "AP3Aase activity", "AP(3)A hydrolase activity", "AP(3)Aase activity"], "types": ["T044"], "canonical_name": "bis(5'-adenosyl)-triphosphatase activity", "definition": "Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+). [EC:3.6.1.29, RHEA:13893]"}
{"concept_id": "C1323422", "aliases": ["CDPglycerol phosphoglycerohydrolase activity", "cytidine diphosphoglycerol pyrophosphatase activity", "CDP-glycerol phosphoglycerohydrolase activity", "CDP-glycerol pyrophosphatase activity", "CDPglycerol diphosphatase activity", "CDPglycerol pyrophosphatase activity"], "types": ["T044"], "canonical_name": "CDP-glycerol diphosphatase activity", "definition": "Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+). [EC:3.6.1.16, RHEA:21692]"}
{"concept_id": "C1323423", "aliases": ["dCTP nucleotidohydrolase activity", "deoxycytidine-triphosphatase activity", "deoxy-CTPase activity", "deoxycytidine triphosphatase activity", "dCTPase activity", "dCTP pyrophosphatase activity"], "types": ["T044"], "canonical_name": "dCTP diphosphatase activity", "definition": "Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate. [RHEA:22636]"}
{"concept_id": "C1323424", "aliases": ["dolichyl pyrophosphatase activity", "dolichol diphosphatase activity", "dolichyl-diphosphate phosphohydrolase activity", "dolichyl diphosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "dolichyldiphosphatase activity", "definition": "Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate. [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN]"}
{"concept_id": "C1323425", "aliases": ["FAD pyrophosphatase activity", "riboflavine adenine dinucleotide pyrophosphatase activity", "FAD nucleotidohydrolase activity", "flavin adenine dinucleotide pyrophosphatase activity", "flavine adenine dinucleotide pyrophosphatase activity", "FAD pyrophosphohydrolase activity", "riboflavin adenine dinucleotide pyrophosphatase activity"], "types": ["T044"], "canonical_name": "FAD diphosphatase activity", "definition": "Catalysis of the reaction: FAD + H2O = AMP + FMN. [EC:3.6.1.18, MetaCyc:FAD-PYROPHOSPHATASE-RXN]"}
{"concept_id": "C1323426", "aliases": ["7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity", "m7G(5')pppN pyrophosphatase activity", "M(7)G(5')pppN pyrophosphatase activity"], "types": ["T044"], "canonical_name": "m7G(5')pppN diphosphatase activity", "definition": "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. [EC:3.6.1.30, MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN]"}
{"concept_id": "C1323427", "aliases": ["nucleoside-triphosphate diphosphohydrolase activity", "nucleoside-triphosphate pyrophosphatase activity"], "types": ["T044"], "canonical_name": "nucleoside-triphosphate diphosphatase activity", "definition": "Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. [MetaCyc:3.6.1.19-RXN]"}
{"concept_id": "C1323428", "aliases": ["oligosaccharide-diphosphodolichol pyrophosphatase activity", "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity"], "types": ["T044"], "canonical_name": "oligosaccharide-diphosphodolichol diphosphatase activity", "definition": "Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate. [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN]"}
{"concept_id": "C1323429", "aliases": ["diacylglycerol diphosphate phosphatase activity", "DGPP phosphatase activity", "DGPP phosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate. [GOC:kad, PMID:8567632, PMID:9452443]", "canonical_name": "diacylglycerol pyrophosphate phosphatase activity"}
{"concept_id": "C1323430", "aliases": ["thiamine-triphosphate phosphohydrolase activity", "thiamine-triphosphatase activity", "ThTPase activity"], "types": ["T044"], "canonical_name": "thiamin-triphosphatase activity", "definition": "Catalysis of the reaction: H(2)O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate. [EC:3.6.1.28, RHEA:11744]"}
{"concept_id": "C1323431", "aliases": ["thymidine triphosphate nucleotidohydrolase activity", "dTTP nucleotidohydrolase activity", "deoxythymidine-5'-triphosphatase activity", "dTTPase activity"], "types": ["T044"], "canonical_name": "thymidine-triphosphatase activity", "definition": "Catalysis of the reaction: dTTP + H2O = dTDP + phosphate. [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN]"}
{"concept_id": "C1323432", "aliases": ["inorganic trimetaphosphatase activity", "trimetaphosphate hydrolase activity"], "types": ["T044"], "canonical_name": "trimetaphosphatase activity", "definition": "Catalysis of the reaction: H(2)O + trimetaphosphate = 2 H(+) + triphosphate. [EC:3.6.1.2, RHEA:11088]"}
{"concept_id": "C1323433", "aliases": ["inorganic triphosphatase activity", "tripolyphosphatase activity", "triphosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "triphosphatase activity", "definition": "Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate. [EC:3.6.1.25, RHEA:14157]"}
{"concept_id": "C1323434", "aliases": ["isoprenyl pyrophosphatase activity", "C55-isoprenyl diphosphatase activity", "C(55)-isoprenyl diphosphatase activity", "C(55)-isoprenyl pyrophosphatase activity", "undecaprenyl-diphosphate phosphohydrolase activity", "C55-isoprenyl pyrophosphatase activity"], "types": ["T044"], "canonical_name": "undecaprenyl-diphosphatase activity", "definition": "Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate. [PMID:18411271, RHEA:28094]"}
{"concept_id": "C1323435", "aliases": ["adenosine 5-phosphosulfate sulfohydrolase activity", "adenylylsulfate sulfohydrolase activity", "adenylylsulphatase activity"], "types": ["T044"], "canonical_name": "adenylylsulfatase activity", "definition": "Catalysis of the reaction: 5'-adenylyl sulfate + H(2)O = AMP + 2 H(+) + sulfate. [EC:3.6.2.1, RHEA:17041]"}
{"concept_id": "C1323436", "aliases": ["3-phosphoadenylyl sulfatase activity", "3-phosphoadenosine 5-phosphosulfate sulfatase activity", "PAPS sulfatase activity", "phosphoadenylylsulphatase activity", "3'-phosphoadenylylsulfate sulfohydrolase activity"], "types": ["T044"], "canonical_name": "phosphoadenylylsulfatase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate. [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN]"}
{"concept_id": "C1323437", "aliases": ["3-acylpyruvate acylhydrolase activity"], "types": ["T044"], "canonical_name": "acylpyruvate hydrolase activity", "definition": "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate. [EC:3.7.1.5, MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN]"}
{"concept_id": "C1323438", "aliases": ["oxidized PVA hydrolase activity", "b-diketone hydrolase activity", "nonane-4,6-dione acylhydrolase activity"], "types": ["T044"], "canonical_name": "beta-diketone hydrolase activity", "definition": "Catalysis of the reaction: H(2)O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one. [EC:3.7.1.7, RHEA:11908]"}
{"concept_id": "C1323439", "aliases": ["cyclohexane-1,3-dione acylhydrolase (decyclizing)", "1,3-cyclohexanedione hydrolase activity"], "types": ["T044"], "canonical_name": "cyclohexane-1,3-dione hydrolase activity", "definition": "Catalysis of the reaction: cyclohexane-1,3-dione + H(2)O = 5-oxohexanoate + H(+). [EC:3.7.1.10, RHEA:16473]"}
{"concept_id": "C1323440", "aliases": ["2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity"], "types": ["T044"], "canonical_name": "phloretin hydrolase activity", "definition": "Catalysis of the reaction: H(2)O + phloretin = H(+) + phloretate + phloroglucinol. [EC:3.7.1.4, RHEA:23396]"}
{"concept_id": "C1323441", "aliases": ["2-phosphonoacetylaldehyde phosphonohydrolase activity", "2-oxoethylphosphonate phosphonohydrolase activity", "phosphonatase activity", "phosphonoacetylaldehyde phosphonohydrolase activity"], "types": ["T044"], "canonical_name": "phosphonoacetaldehyde hydrolase activity", "definition": "Catalysis of the reaction: H(2)O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate. [EC:3.11.1.1, RHEA:18905]"}
{"concept_id": "C1323442", "aliases": ["phosphonoacetate phosphonohydrolase activity"], "types": ["T044"], "canonical_name": "phosphonoacetate hydrolase activity", "definition": "Catalysis of the reaction: H(2)O + phosphonoacetate = acetate + H(+) + phosphate. [EC:3.11.1.2, RHEA:16749]"}
{"concept_id": "C1323443", "aliases": ["halobenzoate dehalogenase activity", "4-chlorobenzoate chlorohydrolase activity"], "types": ["T044"], "canonical_name": "4-chlorobenzoate dehalogenase activity", "definition": "Catalysis of the reaction: 4-chlorobenzoate + H(2)O = 4-hydroxybenzoate + chloride + H(+). [EC:3.8.1.6, RHEA:23440]"}
{"concept_id": "C1323444", "aliases": ["haloalkane halidohydrolase activity", "alkyl-halide halidohydrolase activity"], "types": ["T044"], "canonical_name": "alkylhalidase activity", "definition": "Catalysis of the reaction: bromochloromethane + H(2)O = bromide + chloride + formaldehyde + 2 H(+). [RHEA:13765]"}
{"concept_id": "C1323446", "aliases": ["phosphamide hydrolase activity", "creatine phosphatase activity"], "types": ["T044"], "canonical_name": "phosphoamidase activity", "definition": "Catalysis of the reaction: N-phosphocreatine + H(2)O = creatine + phosphate. [EC:3.9.1.1, RHEA:12977]"}
{"concept_id": "C1323447", "aliases": ["trithionate thiosulfohydrolase activity"], "types": ["T044"], "canonical_name": "trithionate hydrolase activity", "definition": "Catalysis of the reaction: H(2)O + trithionate = H(+) + sulfate + thiosulfate. [EC:3.12.1.1, RHEA:21884]"}
{"concept_id": "C1323448", "aliases": ["cyclo(glycylglycine) hydrolase activity", "2,5-dioxopiperazine amidohydrolase activity", "cyclo(Gly-Gly) hydrolase activity"], "types": ["T044"], "canonical_name": "2,5-dioxopiperazine hydrolase activity", "definition": "Catalysis of the reaction: 2,5-dioxopiperazine + H(2)O = glycylglycine. [EC:3.5.2.13, RHEA:21808]"}
{"concept_id": "C1323449", "aliases": ["barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)"], "types": ["T044"], "canonical_name": "barbiturase activity", "definition": "Catalysis of the reaction: barbiturate + H2O = malonate + urea. [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN]"}
{"concept_id": "C1323450", "aliases": ["hydantoin hydrolase activity", "L-5-carboxymethylhydantoin amidohydrolase activity"], "types": ["T044"], "canonical_name": "carboxymethylhydantoinase activity", "definition": "Catalysis of the reaction: L-5-carboxymethylhydantoin + H(2)O = N-carbamoyl-L-aspartate + H(+). [EC:3.5.2.4, RHEA:12028]"}
{"concept_id": "C1323451", "aliases": ["creatinine hydrolase", "creatinine amidohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: creatinine + H(2)O = creatine. [EC:3.5.2.10, RHEA:14533]", "canonical_name": "creatininase activity"}
{"concept_id": "C1323452", "aliases": ["4(5)-imidazolone-5(4)-propionic acid hydrolase activity", "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity", "imidazolone-5-propionate hydrolase activity", "imidazolone propionic acid hydrolase activity"], "types": ["T044"], "canonical_name": "imidazolonepropionase activity", "definition": "Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+). [EC:3.5.2.7, RHEA:23660]"}
{"concept_id": "C1323453", "aliases": ["L-lysinamidase activity", "L-alpha-aminocaprolactam hydrolase activity", "L-lysine-1,6-lactam lactamhydrolase activity"], "types": ["T044"], "canonical_name": "L-lysine-lactamase activity", "definition": "Catalysis of the reaction: L-2-aminohexano-6-lactam + H(2)O = L-lysine. [EC:3.5.2.11, RHEA:21388]"}
{"concept_id": "C1323454", "aliases": ["cyclic-imide amidohydrolase (decyclizing)", "cyclic imide hydrolase activity", "cyclic-imide amidohydrolase (decyclicizing)"], "types": ["T044"], "canonical_name": "maleimide hydrolase activity", "definition": "Catalysis of the reaction: H(2)O + maleimide = H(+) + maleamate. [EC:3.5.2.16, RHEA:24476]"}
{"concept_id": "C1323455", "aliases": ["methylhydantoin amidase activity", "N-methylhydantoinase (ATP-hydrolysing)", "N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)", "N-methylhydantoinase activity", "N-methylhydantoin hydrolase activity", "N-methylhydantoin amidohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-methylhydantoin + ATP + 2 H(2)O = N-carbamoylsarcosine + ADP + 3 H(+) + phosphate. [EC:3.5.2.14, RHEA:11720]", "canonical_name": "N-methylhydantoinase (ATP-hydrolyzing) activity"}
{"concept_id": "C1323456", "aliases": ["1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)", "HPC deaminase activity"], "types": ["T044"], "canonical_name": "1-pyrroline-4-hydroxy-2-carboxylate deaminase activity", "definition": "Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H(2)O + H(+) = 2,5-dioxopentanoate + NH(4)(+). [EC:3.5.4.22, RHEA:10560]"}
{"concept_id": "C1323457", "aliases": ["adenosine (phosphate) deaminase activity", "adenine nucleotide deaminase activity", "adenosine-phosphate aminohydrolase activity"], "types": ["T044"], "canonical_name": "adenosine-phosphate deaminase activity", "definition": "Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP. [EC:3.5.4.17, GOC:bf, MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN]"}
{"concept_id": "C1323458", "aliases": ["ADP aminohydrolase activity", "adenosinepyrophosphate deaminase activity", "adenosine diphosphate deaminase activity"], "types": ["T044"], "canonical_name": "ADP deaminase activity", "definition": "Catalysis of the reaction: ADP + H2O = IDP + NH3. [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN]"}
{"concept_id": "C1323459", "aliases": ["4-aminoimidazole aminohydrolase activity", "4-aminoimidazole hydrolase activity"], "types": ["T044"], "canonical_name": "aminoimidazolase activity", "definition": "Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH(3). [RHEA:22348]"}
{"concept_id": "C1323460", "aliases": ["ATP aminohydrolase activity", "adenosine triphosphate deaminase activity"], "types": ["T044"], "canonical_name": "ATP deaminase activity", "definition": "Catalysis of the reaction: ATP + H2O = ITP + NH3. [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN]"}
{"concept_id": "C1323461", "aliases": ["blasticidin-S aminohydrolase activity"], "types": ["T044"], "canonical_name": "blasticidin-S deaminase activity", "definition": "Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3. [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN]"}
{"concept_id": "C1323462", "aliases": ["creatinine desiminase activity", "creatinine iminohydrolase activity"], "types": ["T044"], "canonical_name": "creatinine deaminase activity", "definition": "Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3. [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN]"}
{"concept_id": "C1323463", "aliases": ["deoxyadenosine deaminase reaction"], "types": ["T044"], "canonical_name": "2'-deoxyadenosine deaminase activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1323464", "aliases": ["deoxycytidine aminohydrolase activity"], "types": ["T044"], "canonical_name": "deoxycytidine deaminase activity", "definition": "Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3. [EC:3.5.4.14, MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN]"}
{"concept_id": "C1323465", "aliases": ["guanosine aminase activity", "guanosine aminohydrolase activity"], "types": ["T044"], "canonical_name": "guanosine deaminase activity", "definition": "Catalysis of the reaction: guanosine + H2O = xanthosine + NH3. [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN]"}
{"concept_id": "C1323466", "aliases": ["2-amino-4-hydroxypteridine aminohydrolase activity", "acrasinase activity"], "types": ["T044"], "canonical_name": "pterin deaminase activity", "definition": "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3. [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN]"}
{"concept_id": "C1323467", "aliases": ["1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity"], "types": ["T044"], "canonical_name": "pyrithiamine deaminase activity", "definition": "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3. [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN]"}
{"concept_id": "C1323468", "aliases": ["S-adenosyl-L-homocysteine aminohydrolase activity", "adenosylhomocysteine deaminase activity"], "types": ["T044"], "canonical_name": "S-adenosylhomocysteine deaminase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-homocysteine + H(2)O + H(+) = S-inosyl-L-homocysteine + NH(4)(+). [EC:3.5.4.28, RHEA:20716]"}
{"concept_id": "C1323469", "aliases": ["sepiapterin aminohydrolase activity"], "types": ["T044"], "canonical_name": "sepiapterin deaminase activity", "definition": "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3. [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN]"}
{"concept_id": "C1323470", "aliases": ["(S)-N-acetyl-1-phenylethylamine amidohydrolase activity", "(S)-N-acetylphenylethylamine:H2O hydrolase activity"], "types": ["T044"], "canonical_name": "(S)-N-acetyl-1-phenylethylamine hydrolase activity", "definition": "Catalysis of the reaction: N-acetylphenylethylamine + H(2)O = acetate + phenylethylamine. [EC:3.5.1.85, RHEA:23952]"}
{"concept_id": "C1323471", "aliases": ["alpha-(N-acetylaminomethylene)succinic acid hydrolase activity", "2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)"], "types": ["T044"], "canonical_name": "2-(acetamidomethylene)succinate hydrolase activity", "definition": "Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate. [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN]"}
{"concept_id": "C1323472", "aliases": ["alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity", "2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)", "compound B hydrolase activity"], "types": ["T044"], "canonical_name": "2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity", "definition": "Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H(2)O + H(+) = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO(2) + NH(4)(+). [EC:3.5.1.66, RHEA:17677]"}
{"concept_id": "C1323473", "aliases": ["4-methylene-L-glutamine amidohydrolase activity", "4-methyleneglutamine amidohydrolase activity", "4-methyleneglutamine deamidase activity"], "types": ["T044"], "canonical_name": "4-methyleneglutaminase activity", "definition": "Catalysis of the reaction: 4-methylene-L-glutamine + H(2)O = 4-methylene-L-glutamate + NH(4)(+). [EC:3.5.1.67, RHEA:14741]"}
{"concept_id": "C1323474", "aliases": ["5-aminonorvaleramidase activity", "5-aminovaleramidase activity", "5-aminopentanamide amidohydrolase activity"], "types": ["T044"], "canonical_name": "5-aminopentanamidase activity", "definition": "Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3. [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN]"}
{"concept_id": "C1323475", "aliases": ["N6-acyl-L-lysine amidohydrolase activity", "6-N-acyl-L-lysine amidohydrolase activity", "epsilon-lysine acylase activity"], "types": ["T044"], "canonical_name": "acyl-lysine deacylase activity", "definition": "Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate. [EC:3.5.1.17]"}
{"concept_id": "C1323476", "aliases": ["acylagmatine amidohydrolase activity", "acylagmatine deacylase activity", "benzoylagmatine amidohydrolase activity"], "types": ["T044"], "canonical_name": "acylagmatine amidase activity", "definition": "Catalysis of the reaction: N(4)-benzoylagmatine + H(2)O = agmatine + benzoate. [EC:3.5.1.40, RHEA:15065]"}
{"concept_id": "C1323477", "aliases": ["N-methylhexanamide amidohydrolase activity"], "types": ["T044"], "canonical_name": "alkylamidase activity", "definition": "Catalysis of the reaction: N-methylhexanamide + H(2)O = hexanoate + methylammonium. [EC:3.5.1.39, RHEA:20081]"}
{"concept_id": "C1323478", "aliases": ["pseudocholinesterase (associated with arylacylamidase)", "AAA-1", "aryl-acylamide amidohydrolase activity", "brain acetylcholinesterase (is associated with AAA-2)", "AAA-2"], "types": ["T044"], "canonical_name": "aryl-acylamidase activity", "definition": "Catalysis of the reaction: anilide + H(2)O = a carboxylate + aniline + H(+). [EC:3.5.1.13, RHEA:20297]"}
{"concept_id": "C1323479", "aliases": ["N-acetylarylalkylamine amidohydrolase activity", "aralkyl acylamidase activity"], "types": ["T044"], "canonical_name": "arylalkyl acylamidase activity", "definition": "Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine. [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN]"}
{"concept_id": "C1323480", "aliases": ["biotin-amide amidohydrolase activity", "amidohydrolase biotinidase activity"], "types": ["T044"], "canonical_name": "biotinidase activity", "definition": "Catalysis of the reaction: biotin amide + H2O = biotin + NH3. [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN]"}
{"concept_id": "C1323481", "aliases": ["carnitine amidase activity", "L-carnitine amidase activity", "L-carnitinamidase activity", "L-carnitinamide amidohydrolase activity"], "types": ["T044"], "canonical_name": "carnitinamidase activity", "definition": "Catalysis of the reaction: (R)-carnitinamide + H(2)O = (R)-carnitine + NH(4)(+). [EC:3.5.1.73, RHEA:17537]"}
{"concept_id": "C1323482", "aliases": ["chenodeoxycholoyltaurine amidohydrolase activity"], "types": ["T044"], "canonical_name": "chenodeoxycholoyltaurine hydrolase activity", "definition": "Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine. [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN]"}
{"concept_id": "C1323483", "aliases": ["citrulline ureidase activity", "citrulline hydrolase activity", "L-citrulline N5-carbamoyldihydrolase activity", "L-citrulline 5-N-carbamoyldihydrolase activity"], "types": ["T044"], "canonical_name": "citrullinase activity", "definition": "Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine. [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN]"}
{"concept_id": "C1323484", "aliases": ["D-BAPA-ase activity", "benzoyl-D-arginine arylamidase activity", "N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity"], "types": ["T044"], "canonical_name": "D-benzoylarginine-4-nitroanilide amidase activity", "definition": "Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H(2)O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H(+). [EC:3.5.1.72, RHEA:14421]"}
{"concept_id": "C1323485", "aliases": ["D-glutamine amidohydrolase activity"], "types": ["T044"], "canonical_name": "D-glutaminase activity", "definition": "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate. [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN]"}
{"concept_id": "C1323486", "aliases": ["4-acetamidobutanoate amidohydrolase activity"], "types": ["T044"], "canonical_name": "4-acetamidobutyrate deacetylase activity", "definition": "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate. [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN]"}
{"concept_id": "C1323487", "aliases": ["deacetylase-thiolesterase activity", "aminobutyryl-CoA thiolesterase activity", "4-acetamidobutanoyl-CoA amidohydrolase activity"], "types": ["T044"], "canonical_name": "4-acetamidobutyryl-CoA deacetylase activity", "definition": "Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H(2)O = 4-aminobutanoyl-CoA + acetate. [EC:3.5.1.51, RHEA:22928]"}
{"concept_id": "C1323488", "aliases": ["N-acetylputrescine acetylhydrolase activity"], "types": ["T044"], "canonical_name": "acetylputrescine deacetylase activity", "definition": "Catalysis of the reaction: N-acetylputrescine + H(2)O = acetate + putrescine. [EC:3.5.1.62, RHEA:23412]"}
{"concept_id": "C1323489", "aliases": ["N8-acetylspermidine deacetylase activity", "N8-acetylspermidine amidohydrolase activity", "N(1)-acetylspermidine amidohydrolase activity", "8-N-acetylspermidine amidohydrolase activity", "N1-acetylspermidine amidohydrolase activity", "N(8)-acetylspermidine amidohydrolase activity", "N8-monoacetylspermidine deacetylase activity"], "types": ["T044"], "canonical_name": "acetylspermidine deacetylase activity", "definition": "Catalysis of the reaction: N(8)-acetylspermidine + H(2)O = acetate + spermidine. [EC:3.5.1.48, RHEA:23928]"}
{"concept_id": "C1323490", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent histone deacetylase activity (H3-K9 specific)", "definition": "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. [PMID:28450737]"}
{"concept_id": "C1323491", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent histone deacetylase activity (H4-K16 specific)", "definition": "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. [GOC:vw, PMID:28450737]"}
{"concept_id": "C1323492", "aliases": ["N-acetyl-beta-alanine amidohydrolase activity"], "types": ["T044"], "canonical_name": "N-acetyl-beta-alanine deacetylase activity", "definition": "Catalysis of the reaction: N-acetyl-beta-alanine + H(2)O = beta-alanine + acetate. [EC:3.5.1.21, RHEA:23212]"}
{"concept_id": "C1323493", "aliases": ["6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity", "N-acetyl-LL-diaminopimelate deacylase activity", "N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity", "N-acetyl-L-diaminopimelic acid deacylase activity"], "types": ["T044"], "canonical_name": "N-acetyldiaminopimelate deacetylase activity", "definition": "Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + acetate. [EC:3.5.1.47, RHEA:20405]"}
{"concept_id": "C1323494", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylgalactosamine-6-phosphate deacetylase activity", "definition": "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate. [EC:3.5.1.25, MetaCyc:3.5.1.80-RXN]"}
{"concept_id": "C1323495", "aliases": ["N-acetyl-D-glucosaminyl N-deacetylase activity", "N-acetyl-D-glucosamine amidohydrolase activity", "acetylaminodeoxyglucose acetylhydrolase activity"], "types": ["T044"], "canonical_name": "N-acetylglucosamine deacetylase activity", "definition": "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate. [EC:3.5.1.33, RHEA:20593]"}
{"concept_id": "C1323496", "aliases": [], "types": ["T044"], "canonical_name": "tubulin deacetylase activity", "definition": "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. [PMID:12024216, PMID:12486003]"}
{"concept_id": "C1323497", "aliases": ["formylaspartic formylase (formylase I, formylase II)", "N-formyl-L-aspartate amidohydrolase activity"], "types": ["T044"], "canonical_name": "formylaspartate deformylase activity", "definition": "Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate. [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN]"}
{"concept_id": "C1323498", "aliases": ["L-glutamine(L-asparagine) amidohydrolase activity", "glutaminase-asparaginase activity", "L-asparagine/L-glutamine amidohydrolase activity", "glutaminase-(asparagin-)ase activity", "L-ASNase/L-GLNase activity"], "types": ["T044"], "canonical_name": "glutamin-(asparagin-)ase activity", "definition": "Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate. [EC:3.5.1.38, MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN]"}
{"concept_id": "C1323499", "aliases": ["hippuricase activity", "benzoylglycine amidohydrolase activity", "N-benzoylamino-acid amidohydrolase activity"], "types": ["T044"], "canonical_name": "hippurate hydrolase activity", "definition": "Catalysis of the reaction: N-benzoylglycine + H(2)O = benzoate + glycine. [EC:3.5.1.32, RHEA:10424]"}
{"concept_id": "C1323500", "aliases": ["mandelamide hydrolase activity", "Pseudomonas mandelamide hydrolase activity"], "types": ["T044"], "canonical_name": "mandelamide amidase activity", "definition": "Catalysis of the reaction: (R)-mandelamide + H(2)O = (R)-mandelate + NH(4)(+). [EC:3.5.1.86, RHEA:22876]"}
{"concept_id": "C1323501", "aliases": ["mimosine amidohydrolase activity"], "types": ["T044"], "canonical_name": "mimosinase activity", "definition": "Catalysis of the reaction: L-mimosine + H(2)O = 3-hydroxy-4H-pyrid-4-one + L-serine. [EC:3.5.1.61, RHEA:13373]"}
{"concept_id": "C1323502", "aliases": ["nalpha-benzyloxycarbonylleucine hydrolase activity", "nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity", "alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity", "benzyloxycarbonylleucine hydrolase activity"], "types": ["T044"], "canonical_name": "N(alpha)-benzyloxycarbonylleucine hydrolase activity", "definition": "Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H(2)O + H(+) = L-leucine + benzyl alcohol + CO(2). [EC:3.5.1.64, RHEA:18901]"}
{"concept_id": "C1323503", "aliases": ["dimethylformamidase activity", "N,N-dimethylformamide amidohydrolase activity", "DMFase activity"], "types": ["T044"], "canonical_name": "N,N-dimethylformamidase activity", "definition": "Catalysis of the reaction: N,N-dimethylformamide + H(2)O = dimethylamine + formate. [EC:3.5.1.56, RHEA:19517]"}
{"concept_id": "C1323504", "aliases": ["acylethanolamine amidase activity", "N-(long-chain-acyl)ethanolamine amidohydrolase activity", "N-acylethanolamine amidohydrolase activity"], "types": ["T044"], "canonical_name": "N-(long-chain-acyl)ethanolamine deacylase activity", "definition": "Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid. [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN]"}
{"concept_id": "C1323505", "aliases": ["N-acyl-D-amino acid amidohydrolase activity", "D-aminoacylase activity"], "types": ["T044"], "canonical_name": "N-acyl-D-amino-acid deacylase activity", "definition": "Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid. [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN]"}
{"concept_id": "C1323506", "aliases": ["N-acyl-D-aspartate amidohydrolase activity"], "types": ["T044"], "canonical_name": "N-acyl-D-aspartate deacylase activity", "definition": "Catalysis of the reaction: N-acyl-D-aspartate + H(2)O = D-aspartate + a carboxylate. [EC:3.5.1.83, RHEA:18285]"}
{"concept_id": "C1323507", "aliases": ["N-acyl-D-glutamate amidohydrolase activity"], "types": ["T044"], "canonical_name": "N-acyl-D-glutamate deacylase activity", "definition": "Catalysis of the reaction: N-acyl-D-glutamate + H(2)O = D-glutamate + a carboxylate. [EC:3.5.1.82, RHEA:12833]"}
{"concept_id": "C1323508", "aliases": ["N-benzyloxycarbonylglycine urethanehydrolase activity", "nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity", "nalpha-carbobenzoxyamino acid amidohydrolase activity", "benzyloxycarbonylglycine hydrolase activity"], "types": ["T044"], "canonical_name": "N-benzyloxycarbonylglycine hydrolase activity", "definition": "Catalysis of the reaction: N-benzyloxycarbonylglycine + H(2)O + H(+) = benzyl alcohol + CO(2) + glycine. [EC:3.5.1.58, RHEA:20900]"}
{"concept_id": "C1323509", "aliases": ["N-carbamoyl-D-amino acid amidohydrolase activity"], "types": ["T044"], "canonical_name": "N-carbamoyl-D-amino acid hydrolase activity", "definition": "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid. [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN]"}
{"concept_id": "C1323510", "aliases": ["N-carbamoyl-L-amino acid amidohydrolase activity", "L-carbamoylase activity"], "types": ["T044"], "canonical_name": "N-carbamoyl-L-amino-acid hydrolase activity", "definition": "Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate. [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN]"}
{"concept_id": "C1323511", "aliases": ["N-carbamoylputrescine amidohydrolase activity", "NCP", "carbamoylputrescine hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-carbamoylputrescine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + putrescine. [EC:3.5.1.53, RHEA:22284]", "canonical_name": "N-carbamoylputrescine amidase activity"}
{"concept_id": "C1323512", "aliases": ["carbamoylsarcosine amidase activity", "N-carbamoylsarcosine amidohydrolase activity", "CSHase activity"], "types": ["T044"], "canonical_name": "N-carbamoylsarcosine amidase activity", "definition": "Catalysis of the reaction: N-carbamoylsarcosine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + sarcosine. [EC:3.5.1.59, RHEA:20057]"}
{"concept_id": "C1323513", "aliases": ["N-feruloylglycine hydrolase activity", "N-feruloylglycine amidohydrolase activity"], "types": ["T044"], "canonical_name": "N-feruloylglycine deacylase activity", "definition": "Catalysis of the reaction: N-feruloylglycine + H(2)O = ferulate + glycine. [EC:3.5.1.71, RHEA:10484]"}
{"concept_id": "C1323514", "aliases": ["beta-citryl-L-glutamate amidase activity", "beta-citryl-L-glutamate hydrolase activity", "beta-citrylglutamate amidase activity", "N-formylglutamate hydrolase activity", "beta-citryl-L-glutamate amidohydrolase activity", "N-formyl-L-glutamate amidohydrolase activity", "formylglutamate deformylase activity"], "types": ["T044"], "canonical_name": "N-formylglutamate deformylase activity", "definition": "Catalysis of the reaction: N-formyl-L-glutamate + H(2)O = L-glutamate + formate. [EC:3.5.1.68, RHEA:12476]"}
{"concept_id": "C1323515", "aliases": ["N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity"], "types": ["T044"], "canonical_name": "N-formylmethionylaminoacyl-tRNA deformylase activity", "definition": "Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate. [MetaCyc:3.5.1.27-RXN]"}
{"concept_id": "C1323516", "aliases": ["N-methyl-2-oxoglutaramate methylamidohydrolase activity", "5-hydroxy-N-methylpyroglutamate synthase activity"], "types": ["T044"], "canonical_name": "N-methyl-2-oxoglutaramate hydrolase activity", "definition": "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H(2)O = 2-oxoglutarate + methylammonium. [EC:3.5.1.36, RHEA:24108]"}
{"concept_id": "C1323517", "aliases": ["w-amidase activity", "alpha-keto acid-omega-amidase activity", "omega-amidodicarboxylate amidohydrolase activity"], "types": ["T044"], "canonical_name": "omega-amidase activity", "definition": "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3. [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN]"}
{"concept_id": "C1323518", "aliases": ["valeramidase activity", "pentanamide amidohydrolase activity"], "types": ["T044"], "canonical_name": "pentanamidase activity", "definition": "Catalysis of the reaction: H(2)O + pentanamide = NH(4)(+) + valerate. [EC:3.5.1.50, RHEA:10000]"}
{"concept_id": "C1323519", "aliases": ["polypeptide deformylase activity", "formyl-L-methionyl peptide amidohydrolase activity", "PDF activity"], "types": ["T044"], "canonical_name": "peptide deformylase activity", "definition": "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. [EC:3.5.1.88, GOC:jl]"}
{"concept_id": "C1323520", "aliases": ["peptidoglutaminase activity", "peptidyl-L-glutamine amidohydrolase activity", "peptideglutaminase activity"], "types": ["T044"], "canonical_name": "peptidyl-glutaminase activity", "definition": "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3. [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN]"}
{"concept_id": "C1323521", "aliases": ["phthalyl-amide amidohydrolase activity"], "types": ["T044"], "canonical_name": "phthalyl amidase activity", "definition": "Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine. [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN]"}
{"concept_id": "C1323522", "aliases": ["glutaminylpeptide glutaminase activity", "destabilase activity", "protein-L-glutamine amidohydrolase activity", "glutaminyl-peptide glutaminase activity"], "types": ["T044"], "canonical_name": "protein-glutamine glutaminase activity", "definition": "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3. [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN]"}
{"concept_id": "C1323523", "aliases": ["5-N-ethyl-L-glutamine amidohydrolase activity", "N5-ethyl-L-glutamine amidohydrolase activity", "L-theanine amidohydrolase activity"], "types": ["T044"], "canonical_name": "theanine hydrolase activity", "definition": "Catalysis of the reaction: N(5)-ethyl-L-glutamine + H(2)O = L-glutamate + ethylamine. [EC:3.5.1.65, RHEA:18013]"}
{"concept_id": "C1323524", "aliases": ["L-tryptophanamide amidohydrolase activity"], "types": ["T044"], "canonical_name": "tryptophanamidase activity", "definition": "Catalysis of the reaction: L-tryptophanamide + H(2)O = L-tryptophan + NH(4)(+). [EC:3.5.1.57, RHEA:11012]"}
{"concept_id": "C1323525", "aliases": ["N-carbamoyl-L-aspartate amidohydrolase activity"], "types": ["T044"], "canonical_name": "ureidosuccinase activity", "definition": "Catalysis of the reaction: N-carbamoyl-L-aspartate + H(2)O + 2 H(+) = L-aspartate + CO(2) + NH(4)(+). [EC:3.5.1.7, RHEA:14365]"}
{"concept_id": "C1323526", "aliases": ["urethane amidohydrolase (decarboxylating)", "urethane hydrolase activity"], "types": ["T044"], "canonical_name": "urethanase activity", "definition": "Catalysis of the reaction: H(2)O + H(+) + urethane = CO(2) + ethanol + NH(4)(+). [EC:3.5.1.75, RHEA:21372]"}
{"concept_id": "C1323527", "aliases": ["agmatine iminohydrolase activity"], "types": ["T044"], "canonical_name": "agmatine deiminase activity", "definition": "Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3. [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN]"}
{"concept_id": "C1323528", "aliases": ["allantoate amidohydrolase activity", "allantoate amidinohydrolase (decarboxylating)"], "types": ["T044"], "canonical_name": "allantoate deiminase activity", "definition": "Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine. [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN]"}
{"concept_id": "C1323529", "aliases": ["N-amidino-L-aspartate amidinohydrolase activity", "amidinoaspartic amidinohydrolase activity"], "types": ["T044"], "canonical_name": "amidinoaspartase activity", "definition": "Catalysis of the reaction: N-amidino-L-aspartate + H(2)O = L-aspartate + urea. [EC:3.5.3.14, RHEA:14849]"}
{"concept_id": "C1323530", "aliases": ["D-arginine amidinohydrolase activity"], "types": ["T044"], "canonical_name": "D-arginase activity", "definition": "Catalysis of the reaction: D-arginine + H(2)O = D-ornithine + urea. [EC:3.5.3.10, RHEA:12901]"}
{"concept_id": "C1323531", "aliases": ["1,4-diguanidinobutane amidinohydrolase activity"], "types": ["T044"], "canonical_name": "diguanidinobutanase activity", "definition": "Catalysis of the reaction: 1,4-diguanidinobutane + H(2)O = agmatine + urea. [EC:3.5.3.20, RHEA:13597]"}
{"concept_id": "C1323532", "aliases": ["formiminoaspartate deiminase activity", "N-formimidoyl-L-aspartate iminohydrolase activity"], "types": ["T044"], "canonical_name": "formimidoylaspartate deiminase activity", "definition": "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3. [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN]"}
{"concept_id": "C1323533", "aliases": ["formiminoglutamate hydrolase activity", "N-formimidoyl-L-glutamate formimidoylhydrolase activity", "N-formimino-L-glutamate formiminohydrolase activity", "formiminoglutamase activity", "N-formiminoglutamate hydrolase activity"], "types": ["T044"], "canonical_name": "formimidoylglutamase activity", "definition": "Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide. [EC:3.5.3.8, RHEA:22492]"}
{"concept_id": "C1323534", "aliases": ["formiminoglutamate deiminase activity", "N-formimidoyl-L-glutamate iminohydrolase activity", "formiminoglutamic iminohydrolase activity"], "types": ["T044"], "canonical_name": "formimidoylglutamate deiminase activity", "definition": "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3. [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN]"}
{"concept_id": "C1323535", "aliases": ["glycocyaminase activity", "guanidinoacetate amidinohydrolase activity"], "types": ["T044"], "canonical_name": "guanidinoacetase activity", "definition": "Catalysis of the reaction: guanidinoacetate + H(2)O = glycine + urea. [EC:3.5.3.2, RHEA:23268]"}
{"concept_id": "C1323536", "aliases": ["guanidinobutyrate ureahydrolase activity", "G-base activity", "4-guanidinobutanoate amidinohydrolase activity", "guanidinobutyrase activity", "gamma-guanidinobutyrate amidinohydrolase activity", "4-guanidinobutyrate amidinobutyrase activity", "gamma-guanidobutyrase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-guanidinobutanoate + H(2)O = 4-aminobutanoate + urea. [EC:3.5.3.7, RHEA:19501]", "canonical_name": "GBH"}
{"concept_id": "C1323537", "aliases": ["GPH", "guanidinopropionase activity", "GPase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-guanidinopropanoate + H(2)O = beta-alanine + urea. [EC:3.5.3.17, RHEA:16029]", "canonical_name": "3-guanidinopropanoate amidinopropionase activity"}
{"concept_id": "C1323538", "aliases": ["methylenediurease activity", "methylenediurea aminohydrolase activity"], "types": ["T044"], "canonical_name": "methylenediurea deaminase activity", "definition": "Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea. [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN, RHEA:15929]"}
{"concept_id": "C1323539", "aliases": ["methylguanidine amidinohydrolase activity", "methylguanidine hydrolase activity"], "types": ["T044"], "canonical_name": "methylguanidinase activity", "definition": "Catalysis of the reaction: H(2)O + methylguanidine = methylammonium + urea. [EC:3.5.3.16, RHEA:11764]"}
{"concept_id": "C1323540", "aliases": ["arylacetonitrile aminohydrolase activity"], "types": ["T044"], "canonical_name": "arylacetonitrilase activity", "definition": "Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3. [EC:3.5.5.5, MetaCyc:3.5.5.5-RXN]"}
{"concept_id": "C1323541", "aliases": ["beta-cyanoalanine nitrilase activity", "3-cyano-L-alanine aminohydrolase activity"], "types": ["T044"], "canonical_name": "cyanoalanine nitrilase activity", "definition": "Catalysis of the reaction: 3-cyano-L-alanine + 2 H(2)O + H(+) = L-aspartate + NH(4)(+). [EC:3.5.5.4, RHEA:11188]"}
{"concept_id": "C1323542", "aliases": ["ricinine aminohydrolase activity"], "types": ["T044"], "canonical_name": "ricinine nitrilase activity", "definition": "Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone. [EC:3.5.5.2, MetaCyc:3.5.5.2-RXN]"}
{"concept_id": "C1323543", "aliases": ["2-aminomuconate aminohydrolase activity"], "types": ["T044"], "canonical_name": "2-aminomuconate deaminase activity", "definition": "Catalysis of the reaction: 2-aminomuconate + H(2)O + H(+) = (Z)-5-oxohex-2-enedioate + NH(4)(+). [EC:3.5.99.5, RHEA:20996]"}
{"concept_id": "C1323544", "aliases": ["riboflavin hydrolase activity"], "types": ["T044"], "canonical_name": "riboflavinase activity", "definition": "Catalysis of the reaction: H(2)O + H(+) + riboflavin = D-ribitol + lumichrome. [EC:3.5.99.1, RHEA:11408]"}
{"concept_id": "C1323545", "aliases": [], "types": ["T044"], "canonical_name": "thiaminase activity", "definition": "Catalysis of the reaction: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+). [EC:3.5.99.2, RHEA:17509]"}
{"concept_id": "C1323546", "aliases": [], "types": ["T044"], "canonical_name": "IAA-amino acid conjugate hydrolase activity", "definition": "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid. [GOC:tb]"}
{"concept_id": "C1323547", "aliases": [], "types": ["T044"], "canonical_name": "IAA-Ala conjugate hydrolase activity", "definition": "Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine. [MetaCyc:RXN-2981]"}
{"concept_id": "C1323548", "aliases": ["gamma-lactonase activity", "1,4-lactone hydroxyacylhydrolase activity"], "types": ["T044"], "canonical_name": "1,4-lactonase activity", "definition": "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid. [EC:3.1.1.25, MetaCyc:14-LACTONASE-RXN]"}
{"concept_id": "C1323549", "aliases": ["11-cis-retinyl-palmitate acylhydrolase activity", "RPH", "11-cis-retinol palmitate esterase activity"], "types": ["T044"], "canonical_name": "11-cis-retinyl-palmitate hydrolase activity", "definition": "Catalysis of the reaction: 11-cis-retinyl palmitate + H(2)O = 11-cis-retinol + H(+) + palmitate. [EC:3.1.1.63, RHEA:19697]"}
{"concept_id": "C1323550", "aliases": ["2-pyrone-4,6-dicarboxylate lactonohydrolase activity"], "types": ["T044"], "canonical_name": "2-pyrone-4,6-dicarboxylate lactonase activity", "definition": "Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H(2)O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H(+). [EC:3.1.1.57, RHEA:10644]"}
{"concept_id": "C1323551", "aliases": ["carboxymethylbutenolide lactonase activity", "3-ketoadipate enol-lactonase activity", "beta-ketoadipic enol-lactone hydrolase activity", "4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity", "3-oxoadipic enol-lactone hydrolase activity", "beta-ketoadipate enol-lactone hydrolase activity"], "types": ["T044"], "canonical_name": "3-oxoadipate enol-lactonase activity", "definition": "Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate. [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN]"}
{"concept_id": "C1323552", "aliases": ["oxaloacetate-4-methyl-ester oxaloacetohydrolase activity"], "types": ["T044"], "canonical_name": "4-methyloxaloacetate esterase activity", "definition": "Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H(2)O = H(+) + methanol + oxaloacetate. [EC:3.1.1.44, RHEA:10564]"}
{"concept_id": "C1323553", "aliases": ["4-pyridoxolactone lactonohydrolase activity"], "types": ["T044"], "canonical_name": "4-pyridoxolactonase activity", "definition": "Catalysis of the reaction: 4-pyridoxolactone + H(2)O = 4-pyridoxate + H(+). [EC:3.1.1.27, RHEA:14301]"}
{"concept_id": "C1323554", "aliases": ["5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity", "diacetoxybutynylbithiophene acetate esterase activity", "3,4-diacetoxybutinylbithiophene:4-acetate esterase activity"], "types": ["T044"], "canonical_name": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity", "definition": "Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+). [EC:3.1.1.66, RHEA:16313]"}
{"concept_id": "C1323555", "aliases": ["6-acetyl-D-glucose acetylhydrolase activity", "6-O-acetylglucose deacetylase activity"], "types": ["T044"], "canonical_name": "6-acetylglucose deacetylase activity", "definition": "Catalysis of the reaction: 6-acetyl-D-glucose + H(2)O = D-glucose + acetate + H(+). [EC:3.1.1.33, RHEA:18485]"}
{"concept_id": "C1323556", "aliases": ["5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity", "5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity", "acetoxybutynylbithiophene esterase activity"], "types": ["T044"], "canonical_name": "acetoxybutynylbithiophene deacetylase activity", "definition": "Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+). [EC:3.1.1.54, RHEA:11548]"}
{"concept_id": "C1323557", "aliases": ["2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity", "alkylacetylglycerol acetylhydrolase activity"], "types": ["T044"], "canonical_name": "acetylalkylglycerol acetylhydrolase activity", "definition": "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H(2)O = 1-alkyl-sn-glycerol + acetate + H(+). [EC:3.1.1.71, RHEA:11552]"}
{"concept_id": "C1323558", "aliases": ["aspirin esterase activity", "aspirin hydrolase activity", "acetylsalicylate O-acetylhydrolase activity", "acetylsalicylic acid esterase activity"], "types": ["T044"], "canonical_name": "acetylsalicylate deacetylase activity", "definition": "Catalysis of the reaction: acetylsalicylate + H(2)O = acetate + H(+) + salicylate. [EC:3.1.1.55, RHEA:11752]"}
{"concept_id": "C1323559", "aliases": ["actinomycin lactonohydrolase activity"], "types": ["T044"], "canonical_name": "actinomycin lactonase activity", "definition": "Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone. [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN]"}
{"concept_id": "C1323560", "aliases": ["O-acylcarnitine acylhydrolase activity", "palmitoyl carnitine hydrolase activity", "carnitine ester hydrolase activity", "HACH", "palmitoylcarnitine hydrolase activity", "high activity acylcarnitine hydrolase activity", "palmitoyl-L-carnitine hydrolase activity", "long-chain acyl-L-carnitine hydrolase activity"], "types": ["T044"], "canonical_name": "acylcarnitine hydrolase activity", "definition": "Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine. [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN]"}
{"concept_id": "C1323561", "aliases": ["monoacylglycerolipase activity", "monoglyceridase activity", "fatty acyl monoester lipase activity", "monoglyceride lipase activity", "monoacylglycerol lipase activity", "monoacylglycerol hydrolase activity", "monoglyceride hydrolase activity", "monoglyceridyllipase activity", "glycerol-ester acylhydrolase activity"], "types": ["T044"], "canonical_name": "acylglycerol lipase activity", "definition": "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]"}
{"concept_id": "C1323562", "aliases": [], "types": ["T044"], "canonical_name": "acyloxyacyl hydrolase activity", "definition": "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid. [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN]"}
{"concept_id": "C1323563", "aliases": ["all-trans-retinyl-palmitate hydrolase activity"], "types": ["T044"], "canonical_name": "all-trans-retinyl-palmitate hydrolase activity"}
{"concept_id": "C1323564", "aliases": ["a-amino-acid esterase activity", "alpha-amino-acid ester hydrolase activity", "alpha-amino-acid-ester aminoacylhydrolase activity", "alpha-amino acid ester hydrolase activity"], "types": ["T044"], "canonical_name": "alpha-amino-acid esterase activity", "definition": "Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol. [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN]"}
{"concept_id": "C1323565", "aliases": ["bis(2-ethylhexyl)phthalate acylhydrolase activity", "DEHP esterase activity"], "types": ["T044"], "canonical_name": "bis(2-ethylhexyl)phthalate esterase activity", "definition": "Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H(2)O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+). [EC:3.1.1.60, RHEA:15529]"}
{"concept_id": "C1323566", "aliases": ["cephalosporin C acetylesterase activity", "cephalosporin C acetyl-esterase activity", "cephalosporin-C acetylhydrolase activity", "cephalosporin C acetylase activity", "cephalosporin acetylesterase activity", "cephalosporin C acetyl-hydrolase activity", "cephalosporin C deacetylase activity"], "types": ["T044"], "canonical_name": "cephalosporin-C deacetylase activity", "definition": "Catalysis of the reaction: cephalosporin C + H(2)O = acetate + deacetylcephalosporin C + H(+). [EC:3.1.1.41, RHEA:22596]"}
{"concept_id": "C1323567", "aliases": ["cetraxate-benzyl-ester benzylhydrolase activity"], "types": ["T044"], "canonical_name": "cetraxate benzylesterase activity", "definition": "Catalysis of the reaction: benzyl cetraxate + H(2)O = benzyl alcohol + cetraxate + H(+). [EC:3.1.1.70, RHEA:23460]"}
{"concept_id": "C1323568", "aliases": ["chlorogenic acid esterase activity", "chlorogenase activity"], "types": ["T044"], "canonical_name": "chlorogenate hydrolase activity", "definition": "Catalysis of the reaction: chlorogenate + H(2)O = (-)-quinate + cis-caffeate + H(+). [EC:3.1.1.42, RHEA:20689]"}
{"concept_id": "C1323569", "aliases": ["chlorophyll chlorophyllidohydrolase activity"], "types": ["T044"], "canonical_name": "chlorophyllase activity", "definition": "Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide. [EC:3.1.1.14, MetaCyc:CHLOROPHYLLASE-RXN]"}
{"concept_id": "C1323570", "aliases": ["cutin hydrolase activity"], "types": ["T044"], "canonical_name": "cutinase activity", "definition": "Catalysis of the reaction: cutin + H2O = cutin monomers. [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN]"}
{"concept_id": "C1323571", "aliases": ["D-arabinono-1,4-lactone lactonohydrolase activity"], "types": ["T044"], "canonical_name": "D-arabinonolactonase activity", "definition": "Catalysis of the reaction: D-arabinono-1,4-lactone + H(2)O = D-arabinonate + H(+). [EC:3.1.1.30, RHEA:23108]"}
{"concept_id": "C1323572", "aliases": ["deoxylimonate A-ring-lactonohydrolase activity"], "types": ["T044"], "canonical_name": "deoxylimonate A-ring-lactonase activity", "definition": "Catalysis of the reaction: deoxylimonoate + H(2)O = deoxylimononate D-ring-lactone + H(+). [EC:3.1.1.46, RHEA:14997]"}
{"concept_id": "C1323573", "aliases": ["dihydrocoumarin lipase activity", "dihydrocoumarin lactonohydrolase activity"], "types": ["T044"], "canonical_name": "dihydrocoumarin hydrolase activity", "definition": "Catalysis of the reaction: 3,4-dihydrocoumarin + H(2)O = 3-(2-hydroxyphenyl)propanoate + H(+). [EC:3.1.1.35, RHEA:10360]"}
{"concept_id": "C1323574", "aliases": ["ornithine esterase activity", "N5-acyl-L-ornithine-ester hydrolase activity", "5-N-acyl-L-ornithine-ester hydrolase activity"], "types": ["T044"], "canonical_name": "fusarinine-C ornithinesterase activity", "definition": "Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol. [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN]"}
{"concept_id": "C1323575", "aliases": ["galactolipid lipase activity", "polygalactolipase activity", "galactolipid acylhydrolase activity", "1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity"], "types": ["T044"], "canonical_name": "galactolipase activity", "definition": "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates. [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN]"}
{"concept_id": "C1323576", "aliases": ["D-(-)-3-hydroxybutyrate-dimer hydrolase activity", "(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity"], "types": ["T044"], "canonical_name": "hydroxybutyrate-dimer hydrolase activity", "definition": "Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H(2)O = 2 (R)-3-hydroxybutanoate + H(+). [EC:3.1.1.22, RHEA:10172]"}
{"concept_id": "C1323577", "aliases": ["L-arabinono-1,4-lactone lactonohydrolase activity"], "types": ["T044"], "canonical_name": "L-arabinonolactonase activity", "definition": "Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+). [EC:3.1.1.15, RHEA:16217]"}
{"concept_id": "C1323578", "aliases": ["L-rhamno-gamma-lactonase activity", "L-rhamnono-gamma-lactonase activity", "L-rhamnono-1,4-lactone lactonohydrolase activity"], "types": ["T044"], "canonical_name": "L-rhamnono-1,4-lactonase activity", "definition": "Catalysis of the reaction: L-rhamnono-1,4-lactone + H(2)O = L-rhamnonate + H(+). [EC:3.1.1.65, RHEA:10288]"}
{"concept_id": "C1323579", "aliases": ["limonin lactone hydrolase activity", "limonin-D-ring-lactone hydrolase activity", "limonoate-D-ring-lactone lactonohydrolase activity"], "types": ["T044"], "canonical_name": "limonin-D-ring-lactonase activity", "definition": "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate. [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN]"}
{"concept_id": "C1323580", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent phospholipase A2 activity", "definition": "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. [EC:3.1.1.4]"}
{"concept_id": "C1323581", "aliases": [], "types": ["T044"], "canonical_name": "calcium-independent phospholipase A2 activity", "definition": "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. [EC:3.1.1.4]"}
{"concept_id": "C1323582", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent phospholipase C activity", "definition": "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+. [EC:3.1.4.3]"}
{"concept_id": "C1323583", "aliases": ["4-methylumbelliferyl-acetate acylhydrolase activity"], "types": ["T044"], "canonical_name": "methylumbelliferyl-acetate deacetylase activity", "definition": "Catalysis of the reaction: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate + H(+). [EC:3.1.1.56, RHEA:12208]"}
{"concept_id": "C1323584", "aliases": ["polysaccharide deacetylase activity", "N-acetyl galactosaminoglycan deacetylase activity", "N-acetyl-D-galactosaminoglycan acetylhydrolase activity", "Vi-polysaccharide deacetylase activity"], "types": ["T044"], "canonical_name": "N-acetylgalactosaminoglycan deacetylase activity", "definition": "Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan. [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN]"}
{"concept_id": "C1323585", "aliases": ["lecanorate hydrolase activity"], "types": ["T044"], "canonical_name": "orsellinate-depside hydrolase activity", "definition": "Catalysis of the reaction: H(2)O + orsellinate depside = 2 o-orsellinate + H(+). [EC:3.1.1.40, RHEA:19549]"}
{"concept_id": "C1323586", "aliases": ["diacylphorbate 12-hydrolase activity", "PDEH", "phorbol-12,13-diester 12-ester hydrolase activity", "12,13-diacylphorbate 12-acylhydrolase activity"], "types": ["T044"], "canonical_name": "phorbol-diester hydrolase activity", "definition": "Catalysis of the reaction: H(2)O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate. [EC:3.1.1.51, RHEA:21316]"}
{"concept_id": "C1323587", "aliases": ["1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity", "phosphatidylinositol phospholipase A2 activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol deacylase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H(2)O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H(+). [EC:3.1.1.52, RHEA:18001]"}
{"concept_id": "C1323588", "aliases": ["PHB depolymerase activity", "poly(HASCL) depolymerase activity", "poly(3HB) depolymerase activity", "poly(HA(SCL)) depolymerase activity", "poly[(R)-3-hydroxybutyrate] hydrolase activity"], "types": ["T044"], "canonical_name": "poly(3-hydroxybutyrate) depolymerase activity", "definition": "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5. [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN]"}
{"concept_id": "C1323589", "aliases": ["poly((R)-3-hydroxyoctanoate) hydrolase activity", "PHO depolymerase activity", "poly(HAMCL) depolymerase activity", "poly(HA(MCL)) depolymerase activity", "poly(3HO) depolymerase activity", "poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity", "poly[(R)-3-hydroxyoctanoate] hydrolase activity"], "types": ["T044"], "canonical_name": "poly(3-hydroxyoctanoate) depolymerase activity", "definition": "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5. [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN]"}
{"concept_id": "C1323590", "aliases": ["PNAE activity", "polyneuridine aldehyde hydrolase (decarboxylating)", "polyneuridine aldehyde esterase activity"], "types": ["T044"], "canonical_name": "polyneuridine-aldehyde esterase activity", "definition": "Catalysis of the reaction: H(2)O + polyneuridine aldehyde = 16-epivellosimine + CO(2) + methanol. [EC:3.1.1.78, RHEA:17501]"}
{"concept_id": "C1323591", "aliases": ["retinyl ester hydrolase activity", "retinyl palmitate hydrolase activity", "retinyl-palmitate palmitohydrolase activity", "retinyl palmitate hydrolyase activity"], "types": ["T044"], "canonical_name": "retinyl-palmitate esterase activity", "definition": "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+. [RHEA:21508]"}
{"concept_id": "C1323592", "aliases": ["sinapoylcholine sinapohydrolase activity", "aromatic choline esterase activity"], "types": ["T044"], "canonical_name": "sinapine esterase activity", "definition": "Catalysis of the reaction: O-sinapoylcholine + H(2)O = choline + H(+) + sinapate. [EC:3.1.1.49, RHEA:10016]"}
{"concept_id": "C1323593", "aliases": ["testololactone lactonohydrolase activity"], "types": ["T044"], "canonical_name": "steroid-lactonase activity", "definition": "Catalysis of the reaction: H(2)O + testololactone = H(+) + testolate. [EC:3.1.1.37, RHEA:13721]"}
{"concept_id": "C1323594", "aliases": ["tannin acetylhydrolase activity", "tannin acylhydrolase activity"], "types": ["T044"], "canonical_name": "tannase activity", "definition": "Catalysis of the reaction: digallate + H(2)O = 2 gallate + H(+). [EC:3.1.1.20, RHEA:16365]"}
{"concept_id": "C1323595", "aliases": ["triacetic acid lactone hydrolase activity", "TAL hydrolase activity", "triacetic lactone hydrolase activity", "triacetate lactone hydrolase activity", "triacetolactone lactonohydrolase activity"], "types": ["T044"], "canonical_name": "triacetate-lactonase activity", "definition": "Catalysis of the reaction: H(2)O + triacetate lactone = triacetate. [EC:3.1.1.38, RHEA:22260]"}
{"concept_id": "C1323596", "aliases": ["atropinase activity", "atropine esterase activity", "atropinesterase activity", "atropine acylhydrolase activity", "tropine esterase activity"], "types": ["T044"], "canonical_name": "tropinesterase activity", "definition": "Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine. [EC:3.1.1.10, RHEA:23304]"}
{"concept_id": "C1323597", "aliases": ["glucuronolactonase activity", "D-glucurono-6,2-lactone lactonohydrolase activity"], "types": ["T044"], "canonical_name": "uronolactonase activity", "definition": "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate. [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN]"}
{"concept_id": "C1323598", "aliases": ["WEH", "wax-ester acylhydrolase activity"], "types": ["T044"], "canonical_name": "wax-ester hydrolase activity", "definition": "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate. [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN]"}
{"concept_id": "C1323599", "aliases": ["xylonolactonase activity", "xylono-g-lactonase activity", "D-xylono-1,4-lactone lactonohydrolase activity"], "types": ["T044"], "canonical_name": "xylono-1,4-lactonase activity", "definition": "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate. [EC:3.1.1.68, MetaCyc:XYLONO-14-LACTONASE-RXN]"}
{"concept_id": "C1323600", "aliases": ["bornyl pyrophosphate hydrolase activity", "bornyl diphosphate hydrolase activity", "monoterpenyl-diphosphate diphosphohydrolase activity", "monoterpenyl-pyrophosphatase activity"], "types": ["T044"], "canonical_name": "monoterpenyl-diphosphatase activity", "definition": "Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate. [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN]"}
{"concept_id": "C1323601", "aliases": ["prenyl-pyrophosphatase activity", "prenol pyrophosphatase activity", "prenyl-diphosphate diphosphohydrolase activity", "prenylphosphatase activity"], "types": ["T044"], "canonical_name": "prenyl-diphosphatase activity", "definition": "Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate. [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN]"}
{"concept_id": "C1323602", "aliases": [], "types": ["T045"], "canonical_name": "flap endonuclease activity", "definition": "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. [GOC:jid]"}
{"concept_id": "C1323603", "aliases": ["3' flap endonuclease activity"], "types": ["T045"], "canonical_name": "3'-flap endonuclease activity", "definition": "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis. [GOC:jid, PMID:10635319]"}
{"concept_id": "C1323604", "aliases": ["tRNA 3' endonuclease activity", "3 tRNase activity", "3' tRNase activity", "3' tRNA processing endoribonuclease activity", "tRNA 3 endonuclease activity"], "types": ["T044"], "canonical_name": "3'-tRNA processing endoribonuclease activity", "definition": "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. [PMID:12032089, PMID:21208191]"}
{"concept_id": "C1323605", "aliases": [], "types": ["T044"], "canonical_name": "phosphoric ester hydrolase activity", "definition": "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. [GOC:jl]"}
{"concept_id": "C1323606", "aliases": ["cyclic GMP phosphodiesterase activity", "cyclic 3',5'-GMP phosphodiesterase activity", "cGMP-specific phosphodiesterase activity", "cyclic guanosine 3',5'-phosphate phosphodiesterase activity", "3',5' cyclic-GMP phosphodiesterase activity", "guanosine cyclic 3',5'-phosphate phosphodiesterase activity", "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity", "cGMP phosphodiesterase activity", "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity"], "types": ["T044"], "canonical_name": "3',5'-cyclic-GMP phosphodiesterase activity", "definition": "Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. [RHEA:16957]"}
{"concept_id": "C1323607", "aliases": ["adenylyl-[glutamate-ammonia ligase] hydrolase activity", "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity", "adenylyl-glutamate-ammonia ligase hydrolase activity", "adenylyl-glutamine-synthetasehydrolase activity", "adenylyl(glutamine synthetase) hydrolase activity"], "types": ["T044"], "canonical_name": "[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase", "definition": "Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)]. [MetaCyc:3.1.4.15-RXN]"}
{"concept_id": "C1323608", "aliases": ["1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity"], "types": ["T044"], "canonical_name": "alkylglycerophosphoethanolamine phosphodiesterase activity", "definition": "Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate. [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN]"}
{"concept_id": "C1323609", "aliases": ["cytidine monophosphate-N-acetylneuraminic acid hydrolase activity", "CMP-sialate hydrolase activity", "CMP-sialic acid hydrolase activity", "cytidine monophosphosialate hydrolase activity", "cytidine monophosphosialic hydrolase activity", "CMP-N-acylneuraminic acid hydrolase activity", "CMP-N-acetylneuraminate hydrolase activity", "CMP-N-acylneuraminate N-acylneuraminohydrolase activity"], "types": ["T044"], "canonical_name": "CMP-N-acylneuraminate phosphodiesterase activity", "definition": "Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP. [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN]"}
{"concept_id": "C1323610", "aliases": ["calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity", "calcium- and calmodulin-regulated cGMP phosphodiesterase activity", "calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity", "calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity", "calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity"], "types": ["T044"], "canonical_name": "calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity", "definition": "Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin. [GOC:jid]"}
{"concept_id": "C1323611", "aliases": ["dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity", "dolichol phosphoglucose phosphodiesterase activity", "Dol-P-Glc phosphodiesterase activity", "dolichyl-phosphate-glucose phosphodiesterase activity"], "types": ["T044"], "canonical_name": "dolichylphosphate-glucose phosphodiesterase activity", "definition": "Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose. [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN]"}
{"concept_id": "C1323612", "aliases": ["dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity", "mannosylphosphodolichol phosphodiesterase activity"], "types": ["T044"], "canonical_name": "dolichylphosphate-mannose phosphodiesterase activity", "definition": "Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose. [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN]"}
{"concept_id": "C1323613", "aliases": ["6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity", "alpha-glucose-1-phosphate phosphodiesterase activity"], "types": ["T044"], "canonical_name": "glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity", "definition": "Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate. [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN]"}
{"concept_id": "C1323614", "aliases": ["rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity", "rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity"], "types": ["T044"], "canonical_name": "glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity", "definition": "Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H(2)O = glycerol 1-phosphate + H(+). [EC:3.1.4.42, RHEA:16493]"}
{"concept_id": "C1323615", "aliases": ["L-3-glycerylphosphinicocholine cholinephosphohydrolase activity", "sn-glycero-3-phosphocholine cholinephosphohydrolase activity"], "types": ["T044"], "canonical_name": "glycerophosphocholine cholinephosphodiesterase activity", "definition": "Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+). [EC:3.1.4.38, RHEA:19545]"}
{"concept_id": "C1323616", "aliases": ["sn-glycero-3-phosphocholine glycerophosphohydrolase activity", "glycerolphosphorylcholine phosphodiesterase activity", "glycerylphosphorylcholinediesterase activity", "sn-glycero-3-phosphorylcholine diesterase activity", "glycerophosphinicocholine diesterase activity", "glycerophosphohydrolase activity"], "types": ["T044"], "canonical_name": "glycerophosphocholine phosphodiesterase activity", "definition": "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline. [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN]"}
{"concept_id": "C1323617", "aliases": ["sn-glycero(3)phosphoinositol glycerophosphohydrolase activity", "sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity", "1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity"], "types": ["T044"], "canonical_name": "glycerophosphoinositol glycerophosphodiesterase activity", "definition": "Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+). [EC:3.1.4.44, RHEA:16501]"}
{"concept_id": "C1323618", "aliases": ["D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity", "D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity", "1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity", "inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity", "D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity", "1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity", "1,2-cyclic-inositol-phosphate phosphodiesterase activity"], "types": ["T044"], "canonical_name": "glycerophosphoinositol inositolphosphodiesterase activity", "definition": "Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol. [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN]"}
{"concept_id": "C1323619", "aliases": ["serine-phosphoethanolamine ethanolaminephosphohydrolase activity", "serine ethanolamine phosphodiester phosphodiesterase activity", "SEP diesterase activity"], "types": ["T044"], "canonical_name": "serine-ethanolaminephosphate phosphodiesterase activity", "definition": "Catalysis of the reaction: H(2)O + serine phosphoethanolamine = H(+) + phosphoethanolamine + serine. [EC:3.1.4.13, RHEA:17113]"}
{"concept_id": "C1323620", "aliases": ["sphingomyelinase D", "sphingomyelin phosphodiesterase D activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+). [EC:3.1.4.41, RHEA:20984]", "canonical_name": "sphingomyelin ceramide-phosphohydrolase activity"}
{"concept_id": "C1323621", "aliases": ["2-carboxyarabinitol 1-phosphatase activity", "2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity", "2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "2-carboxy-D-arabinitol-1-phosphatase activity", "definition": "Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H(2)O = 2-carboxy-D-arabinitol + phosphate. [EC:3.1.3.63, RHEA:17837]"}
{"concept_id": "C1323622", "aliases": ["(R)-2-phospho-3-sulfolactate phosphohydrolase activity", "2-phosphosulpholactate phosphatase activity", "(2R)-phosphosulfolactate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "2-phosphosulfolactate phosphatase activity", "definition": "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H(2)O = (R)-3-sulfolactate + phosphate. [EC:3.1.3.71, RHEA:23416]"}
{"concept_id": "C1323623", "aliases": ["3-PGA phosphatase activity", "D-3-phosphoglycerate phosphatase activity", "D-glycerate-3-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "3-phosphoglycerate phosphatase activity", "definition": "Catalysis of the reaction: 3-phospho-D-glycerate + H(2)O = D-glycerate + phosphate. [EC:3.1.3.38, RHEA:12412]"}
{"concept_id": "C1323624", "aliases": ["myo-inositol-hexakisphosphate 5-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "5-phytase activity", "definition": "Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate. [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN]"}
{"concept_id": "C1323625", "aliases": ["3-(ADP)-2-phosphoglycerate phosphohydrolase activity", "adenosine diphosphate phosphoglycerate phosphatase activity", "ADPphosphoglycerate phosphatase activity"], "types": ["T044"], "canonical_name": "ADP-phosphoglycerate phosphatase activity", "definition": "Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H(2)O = 3-ADP-glycerate + phosphate. [EC:3.1.3.28, RHEA:15861]"}
{"concept_id": "C1323626", "aliases": ["1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity", "alkylacetylglycerophosphate phosphatase activity", "1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "alkylacetylglycerophosphatase activity", "definition": "Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H(2)O = 2-acetyl-1-alkyl-sn-glycerol + phosphate. [EC:3.1.3.59, RHEA:18221]"}
{"concept_id": "C1323627", "aliases": ["SMP-I", "smooth muscle caldesmon phosphatase activity", "caldesmon-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "caldesmon-phosphatase activity", "definition": "Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate. [EC:3.1.3.55, MetaCyc:CALDESMON-PHOSPHATASE-RXN]"}
{"concept_id": "C1323628", "aliases": ["3'-deoxynucleotidase activity", "3'-deoxyribonucleotidase activity", "deoxyribonucleotide 3'-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "deoxynucleotide 3'-phosphatase activity", "definition": "Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate. [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN]"}
{"concept_id": "C1323629", "aliases": ["polyisoprenyl phosphate phosphatase activity", "dolichol phosphatase activity", "dolichyl phosphate phosphatase activity", "dolichol phosphate phosphatase activity", "dolichyl pyrophosphate phosphatase activity", "dolichyl-phosphate phosphohydrolase activity", "Dol-P-P phosphohydrolase activity", "polyprenylphosphate phosphatase activity", "dolichol monophosphatase activity", "Dol-P phosphatase activity", "dolichyl monophosphate phosphatase activity"], "types": ["T044"], "canonical_name": "dolichyl-phosphatase activity", "definition": "Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate. [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN]"}
{"concept_id": "C1323630", "aliases": ["D-fructose-2,6-bisphosphate 6-phosphohydrolase activity", "fructose-2,6-bisphosphate 6-phosphohydrolase activity", "fructose 2,6-bisphosphate-6-phosphohydrolase activity", "beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "fructose-2,6-bisphosphate 6-phosphatase activity", "definition": "Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H(2)O = beta-D-fructofuranose 2-phosphate + phosphate. [EC:3.1.3.54, RHEA:13333]"}
{"concept_id": "C1323631", "aliases": ["StpA", "2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity", "salt tolerance protein A"], "types": ["T044"], "canonical_name": "glucosylglycerol 3-phosphatase activity", "definition": "Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H(2)O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate. [EC:3.1.3.69, RHEA:22652]"}
{"concept_id": "C1323632", "aliases": ["2-glycerophosphatase activity", "beta-glycerophosphate phosphatase activity", "beta-glycerophosphatase activity", "glycerol-2-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "glycerol-2-phosphatase activity", "definition": "Catalysis of the reaction: glycerol 2-phosphate + H(2)O = glycerol + phosphate. [EC:3.1.3.19, RHEA:13105]"}
{"concept_id": "C1323633", "aliases": ["1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity", "1-guanidino-scyllo-inositol 4-phosphatase activity", "1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity"], "types": ["T044"], "canonical_name": "guanidinodeoxy-scyllo-inositol-4-phosphatase activity", "definition": "Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H(2)O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate. [EC:3.1.3.40, RHEA:15777]"}
{"concept_id": "C1323634", "aliases": ["MIPP activity"], "types": ["T044"], "canonical_name": "multiple inositol-polyphosphate phosphatase activity"}
{"concept_id": "C1323635", "aliases": [], "types": ["T044"], "canonical_name": "lipid phosphatase activity", "definition": "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. [GOC:jl]"}
{"concept_id": "C1323636", "aliases": ["D-mannitol-1-phosphate phosphohydrolase activity", "mannitol-1-phosphate phosphatase activity"], "types": ["T044"], "canonical_name": "mannitol-1-phosphatase activity", "definition": "Catalysis of the reaction: D-mannitol 1-phosphate + H(2)O = D-mannitol + 2 H(+) + phosphate. [EC:3.1.3.22, RHEA:19537]"}
{"concept_id": "C1323637", "aliases": ["alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "mannosyl-3-phosphoglycerate phosphatase activity", "definition": "Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate. [EC:3.1.3.70, RHEA:19309]"}
{"concept_id": "C1323638", "aliases": ["S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity", "methylthiophosphoglycerate phosphatase activity"], "types": ["T044"], "canonical_name": "methylphosphothioglycerate phosphatase activity", "definition": "Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H(2)O = S-methyl-1-thio-D-glycerate + phosphate. [EC:3.1.3.14, RHEA:16081]"}
{"concept_id": "C1323639", "aliases": ["myosin-light-chain phosphatase activity", "myosin light chain kinase phosphatase activity", "myosin light-chain kinase phosphatase activity", "[Myosin light-chain]-phosphatase activity", "myosin-light-chain-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "myosin-light-chain-phosphatase activity", "definition": "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN]"}
{"concept_id": "C1323640", "aliases": ["N-acylneuraminic acid 9-phosphate phosphatase activity", "acylneuraminate 9-phosphatase activity", "N-acylneuraminate-9-phosphate phosphohydrolase activity", "N-acylneuraminic (sialic) acid 9-phosphatase activity"], "types": ["T044"], "canonical_name": "N-acylneuraminate-9-phosphatase activity", "definition": "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate. [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN]"}
{"concept_id": "C1323641", "aliases": ["GMP 5' nucleotidase activity"], "types": ["T044"], "canonical_name": "GMP 5'-nucleotidase activity", "definition": "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate. [GOC:ai]"}
{"concept_id": "C1323642", "aliases": ["IMP 5' nucleotidase activity"], "types": ["T044"], "canonical_name": "IMP 5'-nucleotidase activity", "definition": "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate. [GOC:ai]"}
{"concept_id": "C1323643", "aliases": ["PEP phosphatase activity", "phosphoenolpyruvate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "phosphoenolpyruvate phosphatase activity", "definition": "Catalysis of the reaction: H(2)O + phosphoenolpyruvate = phosphate + pyruvate. [EC:3.1.3.60, RHEA:19997]"}
{"concept_id": "C1323644", "aliases": ["D-glycerate-2-phosphate phosphohydrolase activity", "glycerophosphate phosphatase activity", "D-2-phosphoglycerate phosphatase activity"], "types": ["T044"], "canonical_name": "phosphoglycerate phosphatase activity", "definition": "Catalysis of the reaction: 2-phospho-D-glycerate + H(2)O = D-glycerate + phosphate. [EC:3.1.3.20, RHEA:21156]"}
{"concept_id": "C1323645", "aliases": ["sedoheptulose bisphosphatase activity", "sedoheptulose 1,7-diphosphate phosphatase activity", "sedoheptulose 1,7-bisphosphatase activity", "SBPase activity", "sedoheptulose-1,7-bisphosphatase activity", "sedoheptulose 1,7-diphosphatase activity", "sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity", "sedoheptulose diphosphatase activity"], "types": ["T044"], "canonical_name": "sedoheptulose-bisphosphatase activity", "definition": "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate. [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN]"}
{"concept_id": "C1323646", "aliases": ["sorbitol-6-phosphate phosphohydrolase activity", "sorbitol-6-phosphate phosphatase activity"], "types": ["T044"], "canonical_name": "sorbitol-6-phosphatase activity", "definition": "Catalysis of the reaction: D-glucitol 6-phosphate + H(2)O = D-glucitol + phosphate. [EC:3.1.3.50, RHEA:24580]"}
{"concept_id": "C1323647", "aliases": ["streptomycin-6-phosphate phosphohydrolase activity", "streptomycin-6-P phosphohydrolase activity", "streptomycin 6-phosphate phosphohydrolase activity", "streptomycin 6-phosphate phosphatase activity"], "types": ["T044"], "canonical_name": "streptomycin-6-phosphatase activity", "definition": "Catalysis of the reaction: H(2)O + streptomycin 6-phosphate = phosphate + streptomycin. [EC:3.1.3.39, RHEA:10688]"}
{"concept_id": "C1323649", "aliases": ["sugar-phosphate phosphohydrolase activity", "sugar-phosphate phosphatase activity"], "types": ["T044"], "canonical_name": "sugar-phosphatase activity", "definition": "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN]"}
{"concept_id": "C1323650", "aliases": ["sugar-omega-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "sugar-terminal-phosphatase activity", "definition": "Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate. [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN]"}
{"concept_id": "C1323651", "aliases": ["thymidylate 5'-phosphohydrolase activity", "deoxythymidylic 5'-nucleotidase activity", "deoxythymidylate phosphohydrolase activity", "thymidylate 5' phosphatase activity", "dTMPase activity", "deoxythymidylate 5'-nucleotidase activity", "thymidylate nucleotidase activity", "thymidylate 5'-nucleotidase activity"], "types": ["T044"], "canonical_name": "thymidylate 5'-phosphatase activity", "definition": "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate. [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN]"}
{"concept_id": "C1323652", "aliases": ["3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity", "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity", "branched-chain alpha-keto acid dehydrogenase phosphatase", "branched-chain 2-keto acid dehydrogenase phosphatase activity", "branched-chain oxo-acid dehydrogenase phosphatase activity"], "types": ["T044"], "canonical_name": "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity", "definition": "Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]. [EC:3.1.3.52, MetaCyc:3.1.3.52-RXN]"}
{"concept_id": "C1323653", "aliases": ["acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity", "acetyl-CoA carboxylase-phosphatase activity"], "types": ["T044"], "canonical_name": "[acetyl-CoA carboxylase]-phosphatase activity", "definition": "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate. [EC:3.1.3.44, MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN]"}
{"concept_id": "C1323654", "aliases": ["glycogen-synthase-D phosphatase activity", "UDP-glycogen glucosyltransferase phosphatase activity", "glycogen glucosyltransferase phosphatase activity", "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity", "glycogen synthase phosphatase activity", "UDPglucose-glycogen glucosyltransferase phosphatase activity", "glycogen synthase D phosphatase activity", "Mg2+ dependent glycogen synthase phosphatase activity", "uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity", "UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity", "glycogen synthetase phosphatase activity"], "types": ["T044"], "canonical_name": "[glycogen-synthase-D] phosphatase activity", "definition": "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate. [EC:3.1.3.42, MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN]"}
{"concept_id": "C1323655", "aliases": ["hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity", "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity", "definition": "Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]. [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN]"}
{"concept_id": "C1323656", "aliases": ["phosphorylase a phosphatase activity", "protein phosphatase type 1 activity", "phosphorylase a phosphohydrolase activity", "glycogen phosphorylase phosphatase activity", "type 1 protein phosphatase activity", "phosphorylase phosphatase activity"], "types": ["T044"], "canonical_name": "[phosphorylase] phosphatase activity", "definition": "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate. [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN]"}
{"concept_id": "C1323657", "aliases": ["pyruvate kinase phosphatase activity", "pyruvate kinase-phosphatase activity", "ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "[pyruvate kinase]-phosphatase activity", "definition": "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate. [EC:3.1.3.49, MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN]"}
{"concept_id": "C1323658", "aliases": ["somanase activity", "OPAA activity", "organophosphate acid anhydrase activity", "diisopropyl phosphorofluoridate hydrolase activity", "OPA anhydrase activity", "DFPase activity", "diisopropylphosphofluoridase activity", "dialkylfluorophosphatase activity", "diisopropyl-fluorophosphate fluorohydrolase activity", "isopropylphosphorofluoridase activity", "tabunase activity", "diisopropylfluorophosphonate dehalogenase activity", "organophosphorus acid anhydrolase activity"], "types": ["T044"], "canonical_name": "diisopropyl-fluorophosphatase activity", "definition": "Catalysis of the reaction: diisopropyl fluorophosphate + H(2)O = diisopropyl phosphate + 2 H(+) + hydrogen fluoride. [EC:3.1.8.2, RHEA:24100]"}
{"concept_id": "C1323659", "aliases": ["choline-sulfate sulfohydrolase activity", "choline-sulphatase activity"], "types": ["T044"], "canonical_name": "choline-sulfatase activity", "definition": "Catalysis of the reaction: choline sulfate + H(2)O = choline + H(+) + sulfate. [EC:3.1.6.6, RHEA:20820]"}
{"concept_id": "C1323660", "aliases": ["(S)-2-O-sulfolactate 2-sulfohydrolase activity", "D-lactate-2-sulphatase activity"], "types": ["T044"], "canonical_name": "D-lactate-2-sulfatase activity", "definition": "Catalysis of the reaction: (R)-2-O-sulfolactate + H(2)O = (R)-lactate + H(+) + sulfate. [EC:3.1.6.17, RHEA:20337]"}
{"concept_id": "C1323661", "aliases": ["N-sulfoglucosamine-6-sulfatase activity", "N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity", "6,N-disulfoglucosamine 6-O-sulfohydrolase activity", "disulphoglucosamine-6-sulphatase activity"], "types": ["T044"], "canonical_name": "disulfoglucosamine-6-sulfatase activity", "definition": "Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H(2)O = N-sulfo-D-glucosamine + H(+) + sulfate. [EC:3.1.6.11, RHEA:15517]"}
{"concept_id": "C1323662", "aliases": ["glucosulfatase activity", "sugar-sulfate sulfohydrolase activity", "glycosulphatase activity"], "types": ["T044"], "canonical_name": "glycosulfatase activity", "definition": "Catalysis of the reaction: D-glucose 6-sulfate + H(2)O = D-glucose + H(+) + sulfate. [EC:3.1.6.3, RHEA:19145]"}
{"concept_id": "C1323663", "aliases": ["monomethyl-sulfate sulfohydrolase activity", "monomethyl-sulphatase activity"], "types": ["T044"], "canonical_name": "monomethyl-sulfatase activity", "definition": "Catalysis of the reaction: H(2)O + monomethyl sulfate = H(+) + methanol + sulfate. [EC:3.1.6.16, RHEA:14221]"}
{"concept_id": "C1323664", "aliases": ["D-methylmalonyl-coenzyme A hydrolase activity"], "types": ["T044"], "canonical_name": "(S)-methylmalonyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: (S)-methylmalonyl-CoA + H(2)O = CoA + H(+) + methylmalonate. [EC:3.1.2.17, RHEA:17345]"}
{"concept_id": "C1323665", "aliases": ["acetoacetyl coenzyme A deacylase activity", "acetoacetyl coenzyme A hydrolase activity", "acetoacetyl CoA deacylase activity"], "types": ["T044"], "canonical_name": "acetoacetyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: acetoacetyl-CoA + H(2)O = acetoacetate + CoA + H(+). [EC:3.1.2.11, RHEA:15673]"}
{"concept_id": "C1323666", "aliases": ["acyl-CoA thioesterase activity", "acyl coenzyme A hydrolase activity", "acyl-CoA thiolesterase activity", "acyl coenzyme A thioesterase activity"], "types": ["T044"], "canonical_name": "acyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. [RHEA:16781]"}
{"concept_id": "C1323667", "aliases": ["acyl-[acyl-carrier protein] hydrolase activity", "S-acyl fatty acid synthase thioesterase activity", "acyl-ACP-hydrolase activity", "acyl-ACP hydrolase activity", "acyl-acyl carrier protein hydrolase activity", "acyl-acyl-carrier-protein hydrolase activity", "acyl-ACP thioesterase activity"], "types": ["T044"], "canonical_name": "acyl-[acyl-carrier-protein] hydrolase activity", "definition": "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid. [EC:3.1.2.14, MetaCyc:RXN-7902]"}
{"concept_id": "C1323668", "aliases": ["lauroyl-ACP hydrolase activity", "lauryl-[acyl-carrier protein] hydrolase activity", "dodecanoyl-ACP hydrolase activity", "lauroyl-[acyl-carrier-protein] hydrolase activity", "dodecanoyl-[acyl-carrier protein] hydrolase activity", "lauryl-acyl-carrier protein hydrolase activity", "lauryl-acyl-carrier-protein hydrolase activity", "dodecanoyl-acyl-carrier-protein hydrolase activity", "dodecyl-[acyl-carrier protein] hydrolase activity"], "types": ["T044"], "canonical_name": "dodecanoyl-[acyl-carrier-protein] hydrolase activity", "definition": "Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]. [EC:3.1.2.21, MetaCyc:3.1.2.21-RXN]"}
{"concept_id": "C1323669", "aliases": ["ADP-dependent medium-chain hydrolase activity", "ADP-dependent medium-chain acyl-thioester hydrolase activity", "ADP-dependent medium-chain acyl-CoA hydrolase activity", "ADP-dependent-medium-chain-acyl-CoA hydrolase activity", "ADP-dependent medium-chain acyl coenzyme A hydrolase activity"], "types": ["T044"], "canonical_name": "ADP-dependent medium-chain-acyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP. [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN]"}
{"concept_id": "C1323670", "aliases": ["ADP-dependent short-chain acyl-CoA thioesterase activity", "ADP-dependent short-chain acyl-CoA hydrolase activity", "ADP-dependent-short-chain-acyl-CoA hydrolase activity", "ADP-dependent short-chain acyl coenzyme A hydrolase activity"], "types": ["T044"], "canonical_name": "ADP-dependent short-chain-acyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA. [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN]"}
{"concept_id": "C1323671", "aliases": ["formyl coenzyme A hydrolase activity"], "types": ["T044"], "canonical_name": "formyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: formyl-CoA + H(2)O = CoA + formate + H(+). [EC:3.1.2.10, RHEA:19741]"}
{"concept_id": "C1323672", "aliases": ["citryl-glutathione thioesterhydrolase activity", "S-acylglutathione hydrolase activity", "glutathione thioesterase activity"], "types": ["T044"], "canonical_name": "glutathione thiolesterase activity", "definition": "Catalysis of the reaction: S-acylglutathione + H(2)O = a carboxylate + glutathione + H(+). [EC:3.1.2.7, RHEA:22708]"}
{"concept_id": "C1323673", "aliases": ["hydroxymethylglutaryl coenzyme A deacylase activity", "(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity", "hydroxymethylglutaryl coenzyme A hydrolase activity", "beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity", "3-hydroxy-3-methylglutaryl-CoA hydrolase activity", "beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity"], "types": ["T044"], "canonical_name": "hydroxymethylglutaryl-CoA hydrolase activity", "definition": "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H(2)O = 3-hydroxy-3-methylglutarate + CoA + H(+). [EC:3.1.2.5, RHEA:16305]"}
{"concept_id": "C1323674", "aliases": [], "types": ["T044"], "canonical_name": "S-succinylglutathione hydrolase activity", "definition": "Catalysis of the reaction: S-succinylglutathione + H(2)O = glutathione + H(+) + succinate. [EC:3.1.2.13, RHEA:16713]"}
{"concept_id": "C1323675", "aliases": ["citrate (pro-3S)-lyase thiolesterase activity", "citrate-(pro-3S)-lyase thiolesterase activity", "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity", "[citrate-(pro-3S)-lyase] thioesterase activity", "citrate lyase deacetylase activity", "citrate-(pro-3S)-lyase thioesterase activity"], "types": ["T044"], "canonical_name": "[citrate-(pro-3S)-lyase] thiolesterase activity", "definition": "Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate. [EC:3.1.2.16, MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN]"}
{"concept_id": "C1323676", "aliases": ["1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity", "lysoplasmalogenase activity"], "types": ["T044"], "canonical_name": "alkenylglycerophosphocholine hydrolase activity", "definition": "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde. [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN]"}
{"concept_id": "C1323677", "aliases": ["1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity"], "types": ["T044"], "canonical_name": "alkenylglycerophosphoethanolamine hydrolase activity", "definition": "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde. [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN]"}
{"concept_id": "C1323678", "aliases": ["hepoxilin epoxide hydrolase activity", "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity", "hepoxilin A3 hydrolase activity"], "types": ["T044"], "canonical_name": "hepoxilin-epoxide hydrolase activity", "definition": "Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate. [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN]"}
{"concept_id": "C1323679", "aliases": ["trans-2,3-epoxysuccinate hydrolase activity", "trans-epoxysuccinate hydratase activity", "tartrate epoxydase activity"], "types": ["T044"], "canonical_name": "trans-epoxysuccinate hydrolase activity", "definition": "Catalysis of the reaction: trans-2,3-epoxysuccinate + H(2)O = (2R,3S)-tartrate. [EC:3.3.2.4, RHEA:20740]"}
{"concept_id": "C1323680", "aliases": ["adenosyl methionine hydrolase activity", "adenosylmethionine lyase activity", "methylmethionine-sulfonium-salt hydrolase activity", "S-adenosylmethionine cleaving enzyme activity", "S-adenosyl-L-methionine hydrolase activity"], "types": ["T044"], "canonical_name": "adenosylmethionine hydrolase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O = S-methyl-5'-thioadenosine + L-homoserine + H(+). [EC:3.3.1.2, RHEA:14645]"}
{"concept_id": "C1323681", "aliases": ["1-methyladenosine ribohydrolase activity", "1-methyladenosine hydrolase activity"], "types": ["T044"], "canonical_name": "1-methyladenosine nucleosidase activity", "definition": "Catalysis of the reaction: 1-methyladenosine + H(2)O = 1-methyladenine + ribofuranose. [EC:3.2.2.13, RHEA:12865]"}
{"concept_id": "C1323682", "aliases": ["adenosine ribohydrolase activity", "adenosinase activity", "adenosine hydrolase activity", "N-ribosyladenine ribohydrolase activity", "ANase activity"], "types": ["T044"], "canonical_name": "adenosine nucleosidase activity", "definition": "Catalysis of the reaction: adenosine + H2O = D-ribose + adenine. [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN]"}
{"concept_id": "C1323683", "aliases": ["dinitrogenase reductase activating glycohydrolase activity", "ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity", "azoferredoxin glycosidase activity", "dinitrogenase reductase-activating glycohydrolase activity", "ADP-ribosyl-dinitrogen reductase hydrolase activity", "ADP-ribosyl glycohydrolase activity"], "types": ["T044"], "canonical_name": "ADP-ribosyl-[dinitrogen reductase] hydrolase activity", "definition": "Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]. [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN]"}
{"concept_id": "C1323684", "aliases": ["beta-aspartylacetylglucosaminidase activity", "1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity"], "types": ["T044"], "canonical_name": "beta-aspartyl-N-acetylglucosaminidase activity", "definition": "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-D-glucosamine + L-asparagine. [EC:3.2.2.11, RHEA:12324]"}
{"concept_id": "C1323685", "aliases": ["5'-inosinate phosphoribohydrolase activity"], "types": ["T044"], "canonical_name": "inosinate nucleosidase activity", "definition": "Catalysis of the reaction: H(2)O + IMP = D-ribose 5-phosphate + hypoxanthine. [EC:3.2.2.12, RHEA:20469]"}
{"concept_id": "C1323686", "aliases": ["inosine-guanosine nucleosidase activity", "inosinase activity", "inosine ribohydrolase activity"], "types": ["T044"], "canonical_name": "inosine nucleosidase activity", "definition": "Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine. [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN]"}
{"concept_id": "C1323687", "aliases": ["NAD(P)+ glycohydrolase activity", "NAD(P)ase activity", "triphosphopyridine nucleotidase activity", "nicotinamide adenine dinucleotide (phosphate) nucleosidase activity", "NAD(P)(+) nucleosidase activity", "nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity", "NAD(P) nucleosidase activity"], "types": ["T044"], "canonical_name": "NAD(P)+ nucleosidase activity", "definition": "Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide. [EC:3.2.2.6, MetaCyc:NADP+-NUCLEOSIDASE-RXN]"}
{"concept_id": "C1323688", "aliases": ["pyrimidine nucleotide N-ribosidase activity", "Pyr5N activity", "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity"], "types": ["T044"], "canonical_name": "pyrimidine-5'-nucleotide nucleosidase activity", "definition": "Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine. [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN]"}
{"concept_id": "C1323689", "aliases": ["pyrimidine-nucleoside ribohydrolase activity", "pyrimidine nucleosidase activity", "N-ribosylpyrimidine ribohydrolase activity", "RihB", "N-ribosylpyrimidine nucleosidase activity", "YeiK"], "types": ["T044"], "canonical_name": "ribosylpyrimidine nucleosidase activity", "definition": "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine. [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN]"}
{"concept_id": "C1323690", "aliases": ["almond emulsin fucosidase activity", "2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity", "alpha-(1->2)-L-fucosidase activity"], "types": ["T044"], "canonical_name": "1,2-alpha-L-fucosidase activity", "definition": "Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside. [EC:3.2.1.63, MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN]"}
{"concept_id": "C1323691", "aliases": ["2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity", "2-deoxy-alpha-D-glucosidase activity", "2-deoxy-alpha-glucosidase activity"], "types": ["T044"], "canonical_name": "2-deoxyglucosidase activity", "definition": "Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol. [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN]"}
{"concept_id": "C1323692", "aliases": ["3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity", "alpha-Kdo-ase activity"], "types": ["T044"], "canonical_name": "3-deoxyoctulosonase activity", "definition": "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide. [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN]"}
{"concept_id": "C1323693", "aliases": ["amygdalin glucosidase activity", "amygdalin b-glucosidase activity", "(R)-amygdalin beta-glucosidase activity", "amygdalin hydrolase activity", "amygdalin beta-D-glucohydrolase activity"], "types": ["T044"], "canonical_name": "amygdalin beta-glucosidase activity", "definition": "Catalysis of the reaction: (R)-amygdalin + H(2)O = (R)-prunasin + D-glucose. [EC:3.2.1.117, RHEA:14177]"}
{"concept_id": "C1323694", "aliases": ["endo-alpha-1,5-arabanase activity", "endo-1,5-alpha-L-arabinanase activity", "1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity", "endo-arabanase activity"], "types": ["T044"], "canonical_name": "arabinan endo-1,5-alpha-L-arabinosidase activity", "definition": "Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans. [EC:3.2.1.99]"}
{"concept_id": "C1323695", "aliases": ["b-L-arabinosidase activity", "vicianosidase activity", "beta-L-arabinoside arabinohydrolase activity"], "types": ["T044"], "canonical_name": "beta-L-arabinosidase activity", "definition": "Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol. [EC:3.2.1.88, MetaCyc:BETA-L-ARABINOSIDASE-RXN]"}
{"concept_id": "C1323696", "aliases": ["6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity", "b-primeverosidase activity"], "types": ["T044"], "canonical_name": "beta-primeverosidase activity", "definition": "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol. [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN]"}
{"concept_id": "C1323697", "aliases": ["coniferin b-glucosidase activity", "coniferin beta-D-glucosidase activity", "coniferin-hydrolyzing beta-glucosidase activity"], "types": ["T044"], "canonical_name": "coniferin beta-glucosidase activity", "definition": "Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol. [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN]"}
{"concept_id": "C1323698", "aliases": ["cycloheptaglucanase activity", "cyclomaltodextrin dextrin-hydrolase (decyclizing)", "cyclodextrinase activity", "cyclohexaglucanase activity"], "types": ["T044"], "canonical_name": "cyclomaltodextrinase activity", "definition": "Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin. [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN]"}
{"concept_id": "C1323699", "aliases": ["bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity", "inulobiose hydrolase activity"], "types": ["T044"], "canonical_name": "difructose-anhydride synthase activity", "definition": "Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose. [EC:3.2.1.134, MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN]"}
{"concept_id": "C1323700", "aliases": ["oligoglycosylglucosylceramide glycohydrolase activity", "EGCase activity", "endo-glucosylceramidase activity", "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity", "endoglycoceramidase activity"], "types": ["T044"], "canonical_name": "endoglycosylceramidase activity", "definition": "Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose. [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN]"}
{"concept_id": "C1323701", "aliases": ["exo-D-galacturonase activity", "poly(galacturonate) hydrolase activity", "exo-polygalacturonase activity", "exopolygalacturonase activity", "galacturan 1,4-alpha-galacturonidase activity", "exopoly-D-galacturonase activity", "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity", "exo-D-galacturonanase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate. [EC:3.2.1.67, MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN]", "canonical_name": "galacturan alpha-1,4-galacturonidase activity"}
{"concept_id": "C1323702", "aliases": ["guanosine diphosphoglucosidase activity", "guanosine diphosphate D-glucose glucohydrolase activity", "GDP-glucose glucohydrolase activity", "GDPglucosidase activity", "GDPglucose glucohydrolase activity"], "types": ["T044"], "canonical_name": "GDP-glucosidase activity", "definition": "Catalysis of the reaction: GDP-D-glucose + H(2)O = D-glucose + GDP + H(+). [EC:3.2.1.42, RHEA:15049]"}
{"concept_id": "C1323703", "aliases": ["1,3-beta-D-glucan glucanohydrolase activity", "kitalase activity", "(1->3)-beta-glucan 3-glucanohydrolase activity", "callase activity", "(1->3)-beta-glucan endohydrolase activity", "1,3-beta-D-glucan 3-glucanohydrolase activity"], "types": ["T044"], "canonical_name": "glucan endo-1,3-beta-D-glucosidase activity", "definition": "Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans. [EC:3.2.1.39]"}
{"concept_id": "C1323704", "aliases": ["glucuronosyl-disulphoglucosamine glucuronidase activity", "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity", "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity"], "types": ["T044"], "canonical_name": "glucuronosyl-disulfoglucosamine glucuronidase activity", "definition": "Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine. [EC:3.2.1.56, MetaCyc:3.2.1.56-RXN]"}
{"concept_id": "C1323705", "aliases": ["glycyrrhizinate b-glucuronidase activity", "glycyrrhizin beta-hydrolase activity", "glycyrrhizinic acid hydrolase activity", "glycyrrhizin hydrolase activity", "glycyrrhizinate glucuronosylhydrolase activity"], "types": ["T044"], "canonical_name": "glycyrrhizinate beta-glucuronidase activity", "definition": "Catalysis of the reaction: glycyrrhizate + H(2)O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate. [EC:3.2.1.128, RHEA:17369]"}
{"concept_id": "C1323706", "aliases": [], "types": ["T044"], "canonical_name": "lacto-N-biosidase activity", "definition": "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc. [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN]"}
{"concept_id": "C1323707", "aliases": ["lichenase activity", "1,3;1,4-beta-glucan endohydrolase activity", "endo-beta-1,3-1,4 glucanase activity", "1,3;1,4-beta-glucan 4-glucanohydrolase activity", "1,3-1,4-beta-D-glucan 4-glucanohydrolase activity", "1,3-(1,4)-beta-D-glucan 4-glucanohydrolase activity", "1,3-1,4-beta-glucan 4-glucanohydrolase activity", "beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity", "glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group"], "types": ["T044"], "canonical_name": "licheninase activity", "definition": "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds. [EC:3.2.1.73]"}
{"concept_id": "C1323708", "aliases": ["maltose-6'-phosphate 6-phosphoglucohydrolase activity", "phospho-alpha-glucosidase activity"], "types": ["T044"], "canonical_name": "maltose-6'-phosphate glucosidase activity", "definition": "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate. [EC:3.2.1.122, MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN]"}
{"concept_id": "C1323709", "aliases": ["D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity"], "types": ["T044"], "canonical_name": "mucinaminylserine mucinaminidase activity", "definition": "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine. [MetaCyc:3.2.1.110-RXN]"}
{"concept_id": "C1323710", "aliases": ["protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity", "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity"], "types": ["T044"], "canonical_name": "protein-glucosylgalactosylhydroxylysine glucosidase activity", "definition": "Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins. [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN]"}
{"concept_id": "C1323711", "aliases": ["prunasin b-glucosidase activity", "prunasin beta-D-glucohydrolase activity", "prunasin hydrolase activity"], "types": ["T044"], "canonical_name": "prunasin beta-glucosidase activity", "definition": "Catalysis of the reaction: (R)-prunasin + H(2)O = D-glucose + mandelonitrile. [EC:3.2.1.118, RHEA:16489]"}
{"concept_id": "C1323712", "aliases": ["quercitrin 3-L-rhamnohydrolase activity"], "types": ["T044"], "canonical_name": "quercitrinase activity", "definition": "Catalysis of the reaction: H(2)O + quercitrin = L-rhamnose + quercetin. [EC:3.2.1.66, RHEA:17465]"}
{"concept_id": "C1323713", "aliases": ["raucaffricine beta-D-glucohydrolase activity", "raucaffricine glucosidase activity", "raucaffricine beta-D-glucosidase activity", "raucaffricine b-glucosidase activity"], "types": ["T044"], "canonical_name": "raucaffricine beta-glucosidase activity", "definition": "Catalysis of the reaction: H(2)O + raucaffricine = D-glucose + vomilenine. [EC:3.2.1.125, RHEA:14557]"}
{"concept_id": "C1323714", "aliases": ["cholesteryl-beta-D-glucoside glucohydrolase activity", "steryl-b-glucosidase activity"], "types": ["T044"], "canonical_name": "steryl-beta-glucosidase activity", "definition": "Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol. [EC:3.2.1.104, RHEA:11956]"}
{"concept_id": "C1323715", "aliases": ["strictosidine b-glucosidase activity", "strictosidine beta-D-glucohydrolase activity"], "types": ["T044"], "canonical_name": "strictosidine beta-glucosidase activity", "definition": "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = D-glucose + strictosidine aglycone. [EC:3.2.1.105, RHEA:12917]"}
{"concept_id": "C1323716", "aliases": ["vicianin b-glucosidase activity", "vicianin hydrolase activity", "(R)-vicianin beta-D-glucohydrolase activity"], "types": ["T044"], "canonical_name": "vicianin beta-glucosidase activity", "definition": "Catalysis of the reaction: (R)-vicianin + H(2)O = mandelonitrile + vicianose. [EC:3.2.1.119, RHEA:14041]"}
{"concept_id": "C1323717", "aliases": [], "types": ["T044"], "canonical_name": "elastase activity", "definition": "OBSOLETE. Catalysis of the hydrolysis of elastin. [ISBN:0198506732]"}
{"concept_id": "C1323726", "aliases": ["chlorodienelactone isomerase activity", "2-chlorocarboxymethylenebutenolide isomerase activity", "2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity"], "types": ["T044"], "canonical_name": "2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity", "definition": "Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide. [EC:5.2.1.10, RHEA:10924]"}
{"concept_id": "C1323727", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetaldehyde-oxime isomerase activity", "definition": "Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime. [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN]"}
{"concept_id": "C1323728", "aliases": ["farnesol isomerase activity", "2-trans,6-trans-farnesol 2-cis-trans-isomerase activity"], "types": ["T044"], "canonical_name": "farnesol 2-isomerase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol. [EC:5.2.1.9, RHEA:13401]"}
{"concept_id": "C1323729", "aliases": ["2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity"], "types": ["T044"], "canonical_name": "furylfuramide isomerase activity", "definition": "Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide. [EC:5.2.1.6, RHEA:21848]"}
{"concept_id": "C1323730", "aliases": ["linoleate delta12-cis-delta11-trans-isomerase activity", "linoleic acid isomerase activity"], "types": ["T044"], "canonical_name": "linoleate isomerase activity", "definition": "Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate. [EC:5.2.1.5, RHEA:17381]"}
{"concept_id": "C1323731", "aliases": ["maleate cis-trans-isomerase activity"], "types": ["T044"], "canonical_name": "maleate isomerase activity", "definition": "Catalysis of the reaction: maleate = fumarate. [EC:5.2.1.1, RHEA:13169]"}
{"concept_id": "C1323732", "aliases": ["3-maleylpyruvate cis-trans-isomerase activity"], "types": ["T044"], "canonical_name": "maleylpyruvate isomerase activity", "definition": "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate. [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN]"}
{"concept_id": "C1323733", "aliases": ["retinol isomerase activity", "all-trans-retinol 11-cis-trans-isomerase activity", "all-trans-retinol isomerase activity"], "types": ["T044"], "canonical_name": "retinol isomerase activity", "definition": "Catalysis of the reaction: all-trans-retinol = 11-cis-retinol. [GOC:pde, RHEA:19141]"}
{"concept_id": "C1323734", "aliases": ["D-lyxose aldose-ketose-isomerase activity", "D-lyxose isomerase activity"], "types": ["T044"], "canonical_name": "D-lyxose ketol-isomerase activity", "definition": "Catalysis of the reaction: D-lyxose = D-xylulose. [EC:5.3.1.15, RHEA:14201]"}
{"concept_id": "C1323735", "aliases": ["D-galactose-6-phosphate aldose-ketose-isomerase activity", "D-galactose-6-phosphate ketol-isomerase activity"], "types": ["T044"], "canonical_name": "galactose-6-phosphate isomerase activity", "definition": "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate. [EC:5.3.1.26, RHEA:13033]"}
{"concept_id": "C1323736", "aliases": ["D-mannose aldose-ketose-isomerase activity", "D-mannose ketol-isomerase activity", "D-mannose isomerase activity"], "types": ["T044"], "canonical_name": "mannose isomerase activity", "definition": "Catalysis of the reaction: D-mannose = D-fructose. [EC:5.3.1.7, RHEA:22604]"}
{"concept_id": "C1323737", "aliases": ["D-ribose ketol-isomerase activity", "D-ribose aldose-ketose-isomerase activity", "D-ribose isomerase activity"], "types": ["T044"], "canonical_name": "ribose isomerase activity", "definition": "Catalysis of the reaction: ribofuranose = D-ribulose. [EC:5.3.1.20, RHEA:20796]"}
{"concept_id": "C1323738", "aliases": ["oxaloacetate keto-enol-isomerase activity", "oxalacetic keto-enol isomerase activity", "oxaloacetate keto-enol tautomerase activity"], "types": ["T044"], "canonical_name": "oxaloacetate tautomerase activity", "definition": "Catalysis of the reaction: oxaloacetate = <stereo>enol</stereo>-oxaloacetate. [EC:5.3.2.2, RHEA:16021]"}
{"concept_id": "C1323739", "aliases": ["phenylpyruvate keto--enol tautomerase activity", "phenylpyruvic keto--enol isomerase activity", "phenylpyruvate keto-enol-isomerase activity"], "types": ["T044"], "canonical_name": "phenylpyruvate tautomerase activity", "definition": "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate. [RHEA:17097]"}
{"concept_id": "C1323740", "aliases": ["(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity", "prostaglandin R-prostaglandin E isomerase activity", "PGE2 isomerase activity", "prostaglandin-H2 E-isomerase activity", "Prostaglandin-H(2) E-isomerase activity", "prostaglandin H-E isomerase activity", "PGH-PGE isomerase activity", "endoperoxide isomerase activity", "prostaglandin endoperoxide E isomerase activity", "PGE isomerase activity", "prostaglandin endoperoxide E2 isomerase activity"], "types": ["T044"], "canonical_name": "prostaglandin-E synthase activity", "definition": "Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2). [EC:5.3.99.3, RHEA:12893]"}
{"concept_id": "C1323741", "aliases": ["aconitate D-isomerase activity", "aconitate delta2-delta3-isomerase activity"], "types": ["T044"], "canonical_name": "aconitate delta-isomerase activity", "definition": "Catalysis of the reaction: trans-aconitate = cis-aconitate. [RHEA:17265]"}
{"concept_id": "C1323742", "aliases": ["delta7-cholestenol delta7-delta8-isomerase activity", "cholestenol D-isomerase activity"], "types": ["T044"], "canonical_name": "cholestenol delta-isomerase activity", "definition": "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. [RHEA:15281]"}
{"concept_id": "C1323743", "aliases": [], "types": ["T044"], "canonical_name": "delta5-delta2,4-dienoyl-CoA isomerase activity"}
{"concept_id": "C1323744", "aliases": ["isopiperitenone D-isomerase activity", "isopiperitenone delta8-delta4-isomerase activity"], "types": ["T044"], "canonical_name": "isopiperitenone delta-isomerase activity", "definition": "Catalysis of the reaction: isopiperitenone = piperitenone. [RHEA:21516]"}
{"concept_id": "C1323745", "aliases": ["methylitaconate D-isomerase activity", "methylitaconate isomerase activity", "methylitaconate delta2-delta3-isomerase activity"], "types": ["T044"], "canonical_name": "methylitaconate delta-isomerase activity", "definition": "Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate. [RHEA:23480]"}
{"concept_id": "C1323746", "aliases": ["prostaglandin A isomerase activity", "prostaglandin-A1 D-isomerase activity", "(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity"], "types": ["T044"], "canonical_name": "prostaglandin-A1 delta-isomerase activity", "definition": "Catalysis of the reaction: prostaglandin A1 = prostaglandin C1. [RHEA:10460]"}
{"concept_id": "C1323747", "aliases": ["vinylacetyl coenzyme A isomerase activity", "vinylacetyl-CoA D-isomerase activity", "vinylacetyl-CoA delta3-delta2-isomerase activity", "vinylacetyl coenzyme A delta-isomerase activity"], "types": ["T044"], "canonical_name": "vinylacetyl-CoA delta-isomerase activity", "definition": "Catalysis of the reaction: vinylacetyl-CoA = (2E)-butenoyl-CoA. [RHEA:10572]"}
{"concept_id": "C1323748", "aliases": ["CMLE activity", "3-carboxymuconolactone hydrolase activity", "beta-carboxymuconate lactonizing enzyme activity", "3-carboxymuconate lactonizing enzyme activity"], "types": ["T044"], "canonical_name": "3-carboxy-cis,cis-muconate cycloisomerase activity", "definition": "Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+). [PMID:15301541, PMID:17054713, RHEA:23656]"}
{"concept_id": "C1323749", "aliases": ["3-carboxy-cis,cis-muconate lactonizing enzyme activity", "3-carboxymuconate cyclase activity", "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)"], "types": ["T044"], "canonical_name": "carboxy-cis,cis-muconate cyclase activity", "definition": "Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate. [EC:5.5.1.5, RHEA:14977]"}
{"concept_id": "C1323750", "aliases": ["(+)-copalyl-diphosphate lyase (decyclizing)"], "types": ["T044"], "canonical_name": "copalyl diphosphate synthase activity", "definition": "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate. [EC:5.5.1.12, RHEA:24316]"}
{"concept_id": "C1323751", "aliases": ["cycloeucalenol-obtusifoliol isomerase activity", "cycloeucalenol lyase (cyclopropane-decyclizing)", "cycloeucalenol--obtusifoliol isomerase activity"], "types": ["T044"], "canonical_name": "cycloeucalenol cycloisomerase activity", "definition": "Catalysis of the reaction: cycloeucalenol = obtusifoliol. [EC:5.5.1.9, RHEA:22800]"}
{"concept_id": "C1323752", "aliases": ["(+)-bornylpyrophosphate cyclase activity", "bornyl pyrophosphate synthase activity", "bornyl pyrophosphate synthetase activity", "(+)-bornyl-diphosphate lyase (decyclizing)", "bornyl diphosphate synthase activity"], "types": ["T044"], "canonical_name": "geranyl-diphosphate cyclase activity", "definition": "Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate. [EC:5.5.1.8, RHEA:18209]"}
{"concept_id": "C1323753", "aliases": ["tetrahydroxypteridine lyase (isomerizing)"], "types": ["T044"], "canonical_name": "tetrahydroxypteridine cycloisomerase activity", "definition": "Catalysis of the reaction: tetrahydroxypteridine = H(+) + xanthine-8-carboxylate. [EC:5.5.1.3, RHEA:18097]"}
{"concept_id": "C1323754", "aliases": ["phosphoenolpyruvate phosphomutase activity", "PEP phosphomutase activity", "phosphoenolpyruvate 2,3-phosphonomutase activity", "PEPPM", "PEP mutase activity", "phosphoenolpyruvate-phosphonopyruvate phosphomutase activity"], "types": ["T044"], "canonical_name": "phosphoenolpyruvate mutase activity", "definition": "Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate. [EC:5.4.2.9, RHEA:17013]"}
{"concept_id": "C1323755", "aliases": ["alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)", "glucose-1-phosphate phosphotransferase activity"], "types": ["T044"], "canonical_name": "phosphoglucomutase (glucose-cofactor) activity", "definition": "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor. [EC:5.4.2.5, MetaCyc:5.4.2.5-RXN]"}
{"concept_id": "C1323756", "aliases": [], "types": ["T044"], "canonical_name": "6,7-dimethyl-8-ribityllumazine synthase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. [PMID:7559556]"}
{"concept_id": "C1323757", "aliases": ["lysolecithin 2,3-acylmutase activity"], "types": ["T044"], "canonical_name": "lysolecithin acylmutase activity", "definition": "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine. [EC:5.4.1.1, RHEA:24356]"}
{"concept_id": "C1323758", "aliases": ["(3S)-3,6-diaminohexanoate 5,6-aminomutase activity", "L-beta-lysine 5,6-aminomutase activity", "b-lysine 5,6-aminomutase activity", "beta-lysine mutase activity"], "types": ["T044"], "canonical_name": "beta-lysine 5,6-aminomutase activity", "definition": "Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate. [EC:5.4.3.3, RHEA:21736]"}
{"concept_id": "C1323759", "aliases": ["adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity", "D-alpha-lysine mutase activity", "D-2,6-diaminohexanoate 5,6-aminomutase activity"], "types": ["T044"], "canonical_name": "D-lysine 5,6-aminomutase activity", "definition": "Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate. [EC:5.4.3.4, RHEA:18241]"}
{"concept_id": "C1323760", "aliases": ["D-ornithine aminomutase activity", "D-alpha-ornithine 5,4-aminomutase activity"], "types": ["T044"], "canonical_name": "D-ornithine 4,5-aminomutase activity", "definition": "Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate. [EC:5.4.3.5, RHEA:14893]"}
{"concept_id": "C1323761", "aliases": ["(2S)-alpha-leucine 2,3-aminomutase activity"], "types": ["T044"], "canonical_name": "leucine 2,3-aminomutase activity", "definition": "Catalysis of the reaction: L-leucine = (3R)-beta-leucine. [EC:5.4.3.7, RHEA:10284]"}
{"concept_id": "C1323762", "aliases": ["L-lysine 2,3-aminomutase activity"], "types": ["T044"], "canonical_name": "lysine 2,3-aminomutase activity", "definition": "Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate. [EC:5.4.3.2, RHEA:19177]"}
{"concept_id": "C1323763", "aliases": ["tyrosine alpha,beta-mutase activity", "L-tyrosine 2,3-aminomutase activity"], "types": ["T044"], "canonical_name": "tyrosine 2,3-aminomutase activity", "definition": "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate. [EC:5.4.3.6, RHEA:15781]"}
{"concept_id": "C1323764", "aliases": [], "types": ["T044"], "canonical_name": "intramolecular transferase activity, transferring hydroxy groups", "definition": "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule. [GOC:mah]"}
{"concept_id": "C1323765", "aliases": ["malto-oligosyltrehalose synthase activity", "maltodextrin alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity", "definition": "Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside. [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN]"}
{"concept_id": "C1323766", "aliases": ["2-acetolactate methylmutase activity", "acetolactate mutase activity"], "types": ["T044"], "canonical_name": "2-acetolactate mutase activity", "definition": "Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate. [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN]"}
{"concept_id": "C1323767", "aliases": ["alpha-methyleneglutarate mutase activity", "2-methyleneglutarate carboxy-methylenemethylmutase activity"], "types": ["T044"], "canonical_name": "2-methyleneglutarate mutase activity", "definition": "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate. [EC:5.4.99.4, RHEA:13793]"}
{"concept_id": "C1323768", "aliases": ["4-methyl-2-enelactone methyl-isomerase activity", "4-methylmuconolactone methylisomerase activity", "4-methyl-2-enelactone isomerase activity", "4-methyl-3-enelactone methyl isomerase activity", "4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity"], "types": ["T044"], "canonical_name": "4-carboxymethyl-4-methylbutenolide mutase activity", "definition": "Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide. [EC:5.4.99.14, RHEA:19237]"}
{"concept_id": "C1323769", "aliases": ["isobutyryl coenzyme A mutase activity", "2-methylpropanoyl-CoA CoA-carbonylmutase activity", "butyryl-CoA:isobutyryl-CoA mutase activity"], "types": ["T044"], "canonical_name": "isobutyryl-CoA mutase activity", "definition": "Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA. [EC:5.4.99.13, RHEA:13141]"}
{"concept_id": "C1323770", "aliases": ["isomaltulose synthetase activity", "trehalulose synthase activity", "sucrose alpha-glucosyltransferase activity", "sucrose glucosylmutase activity"], "types": ["T044"], "canonical_name": "isomaltulose synthase activity", "definition": "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose. [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN]"}
{"concept_id": "C1323771", "aliases": ["maltose glucosylmutase activity", "trehalose synthase activity", "maltose alpha-D-glucosylmutase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: maltose = trehalose. [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN]", "canonical_name": "maltose alpha-D-glucosyltransferase activity"}
{"concept_id": "C1323772", "aliases": ["glutamic acid mutase activity", "glutamic acid isomerase activity", "glutamic mutase activity", "glutamate mutase activity", "glutamic isomerase activity", "b-methylaspartate-glutamate mutase activity", "methylaspartic acid mutase activity", "glutamate isomerase activity", "beta-methylaspartate-glutamate mutase activity", "L-threo-3-methylaspartate carboxy-aminomethylmutase activity"], "types": ["T044"], "canonical_name": "methylaspartate mutase activity", "definition": "Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate. [EC:5.4.99.1, RHEA:12857]"}
{"concept_id": "C1323773", "aliases": [], "types": ["T044"], "canonical_name": "pseudouridine synthase activity", "definition": "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [GOC:mah]"}
{"concept_id": "C1323774", "aliases": ["isothiocyanate isomerase activity", "benzyl-thiocyanate isomerase activity"], "types": ["T044"], "canonical_name": "thiocyanate isomerase activity", "definition": "Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate. [EC:5.99.1.1, RHEA:10004]"}
{"concept_id": "C1323775", "aliases": ["alpha-amino-epsilon-caprolactam racemase activity", "2-amino-hexano-6-lactam racemase activity"], "types": ["T044"], "canonical_name": "2-aminohexano-6-lactam racemase activity", "definition": "Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam. [EC:5.1.1.15, RHEA:14813]"}
{"concept_id": "C1323776", "aliases": ["hydroxyproline epimerase activity", "hydroxyproline 2-epimerase activity", "L-hydroxyproline epimerase activity", "4-hydroxyproline 2-epimerase activity"], "types": ["T044"], "canonical_name": "4-hydroxyproline epimerase activity", "definition": "Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline. [EC:5.1.1.8, RHEA:21152]"}
{"concept_id": "C1323777", "aliases": ["L-amino acid racemase activity"], "types": ["T044"], "canonical_name": "amino-acid racemase activity", "definition": "Catalysis of the reaction: an L-amino acid = a D-amino acid. [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN]"}
{"concept_id": "C1323778", "aliases": [], "types": ["T044"], "canonical_name": "arginine racemase activity", "definition": "Catalysis of the reaction: L-arginine = D-arginine. [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN]"}
{"concept_id": "C1323779", "aliases": ["D-aspartate racemase activity"], "types": ["T044"], "canonical_name": "aspartate racemase activity", "definition": "Catalysis of the reaction: L-aspartate = D-aspartate. [EC:5.1.1.13, RHEA:14973]"}
{"concept_id": "C1323780", "aliases": ["isonocardicin A epimerase activity"], "types": ["T044"], "canonical_name": "nocardicin-A epimerase activity", "definition": "Catalysis of the reaction: isonocardicin A = nocardicin A. [EC:5.1.1.14, RHEA:22792]"}
{"concept_id": "C1323781", "aliases": [], "types": ["T044"], "canonical_name": "ornithine racemase activity", "definition": "Catalysis of the reaction: L-ornithine = D-ornithine. [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN]"}
{"concept_id": "C1323782", "aliases": ["phenylalanine racemase (ATP-hydrolysing)", "phenylalanine racemase (adenosine triphosphate-hydrolysing)", "phenylalanine racemase (ATP-hydrolyzing) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+). [EC:5.1.1.11, RHEA:20201]", "canonical_name": "phenylalanine racemase activity"}
{"concept_id": "C1323783", "aliases": ["CDP-D-abequose 2-epimerase activity", "cytidine diphosphoabequose epimerase activity", "CDP-3,6-dideoxy-D-glucose 2-epimerase activity", "CDP-paratose 2-epimerase activity", "CDP-paratose epimerase activity", "cytidine diphosphoparatose epimerase activity", "cytidine diphosphodideoxyglucose epimerase activity", "CDP-tyvelose 2-epimerase activity", "cytidine diphosphate paratose-2-epimerase activity"], "types": ["T044"], "canonical_name": "CDP-abequose epimerase activity", "definition": "Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose. [EC:5.1.3.10, RHEA:21656]"}
{"concept_id": "C1323784", "aliases": ["cellobiose 2-epimerase activity"], "types": ["T044"], "canonical_name": "cellobiose epimerase activity", "definition": "Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose. [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN]"}
{"concept_id": "C1323785", "aliases": ["chondroitin D-glucuronosyl 5-epimerase activity", "urunosyl C-5 epimerase activity", "dermatan-sulfate 5-epimerase activity", "chondroitin-D-glucuronate 5-epimerase activity"], "types": ["T044"], "canonical_name": "chondroitin-glucuronate 5-epimerase activity", "definition": "Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate. [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN]"}
{"concept_id": "C1323786", "aliases": ["guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity", "GDP-D-mannose:GDP-L-galactose epimerase activity", "GDPmannose 3,5-epimerase activity"], "types": ["T044"], "canonical_name": "GDP-mannose 3,5-epimerase activity", "definition": "Catalysis of the reaction: GDP-mannose = GDP-L-galactose. [EC:5.1.3.18]"}
{"concept_id": "C1323787", "aliases": ["D-glucose-6-phosphate 1-epimerase activity", "glucose-6 phosphate 1-epimerase activity"], "types": ["T044"], "canonical_name": "glucose-6-phosphate 1-epimerase activity", "definition": "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN]"}
{"concept_id": "C1323789", "aliases": ["maltose 1-epimerase activity"], "types": ["T044"], "canonical_name": "maltose epimerase activity", "definition": "Catalysis of the reaction: alpha-maltose = beta-maltose. [EC:5.1.3.21, RHEA:21228]"}
{"concept_id": "C1323790", "aliases": ["N-acyl-D-glucosamine 2-epimerase activity", "N-acetylglucosamine 2-epimerase activity", "N-acetyl-D-glucosamine 2-epimerase activity", "GlcNAc 2-epimerase activity", "acylglucosamine 2-epimerase activity"], "types": ["T044"], "canonical_name": "N-acylglucosamine 2-epimerase activity", "definition": "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine. [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN]"}
{"concept_id": "C1323791", "aliases": ["N-acetylmannosamine-6-phosphate 2-epimerase activity", "acylglucosamine phosphate 2-epimerase activity", "N-acyl-D-glucosamine-6-phosphate 2-epimerase activity", "acylglucosamine-6-phosphate 2-epimerase activity", "acylmannosamine phosphate 2-epimerase activity", "N-acetylglucosmamine 6-phosphate 2-epimerase activity"], "types": ["T044"], "canonical_name": "N-acylglucosamine-6-phosphate 2-epimerase activity", "definition": "Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN]"}
{"concept_id": "C1323792", "aliases": ["UDP arabinose epimerase activity", "uridine diphosphoarabinose epimerase activity", "uridine 5'-diphosphate-D-xylose 4-epimerase activity", "UDP-L-arabinose 4-epimerase activity", "UDP-D-xylose-4-epimerase activity", "UDP-D-xylose 4-epimerase activity", "UDParabinose 4-epimerase activity"], "types": ["T044"], "canonical_name": "UDP-arabinose 4-epimerase activity", "definition": "Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose. [EC:5.1.3.5, RHEA:11320]"}
{"concept_id": "C1323793", "aliases": ["UDPglucosamine 4-epimerase activity", "UDP-glucosamine epimerase activity"], "types": ["T044"], "canonical_name": "UDP-glucosamine 4-epimerase activity", "definition": "Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine. [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN]"}
{"concept_id": "C1323794", "aliases": ["uridine diphosphoglucuronate epimerase activity", "UDPglucuronate 4-epimerase activity", "UDP glucuronic epimerase activity", "UDP-galacturonate 4-epimerase activity", "UDP-D-galacturonic acid 4-epimerase activity", "uridine diphosphoglucuronic epimerase activity"], "types": ["T044"], "canonical_name": "UDP-glucuronate 4-epimerase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate. [EC:5.1.3.6, RHEA:11404]"}
{"concept_id": "C1323795", "aliases": ["uridine diphosphoglucuronate 5'-epimerase activity", "D-glucuronyl C-5 epimerase activity", "UDP-glucuronic acid 5'-epimerase activity", "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity", "UDP-glucuronic acid epimerase activity", "UDPglucuronate 5'-epimerase activity", "C-5-uronosyl epimerase activity", "heparosan-N-sulfate-glucuronate 5-epimerase activity", "heparosan epimerase activity", "C-5 uronosyl epimerase activity", "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity", "heparosan-N-sulphate-glucuronate 5-epimerase activity", "UDP-glucuronate 5' epimerase activity", "polyglucuronate epimerase activity"], "types": ["T044"], "canonical_name": "UDP-glucuronate 5'-epimerase activity", "definition": "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate. [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN]"}
{"concept_id": "C1323796", "aliases": ["acetylmethylcarbinol racemase activity"], "types": ["T044"], "canonical_name": "acetoin racemase activity", "definition": "Catalysis of the reaction: (S)-acetoin = (R)-acetoin. [EC:5.1.2.4, RHEA:12092]"}
{"concept_id": "C1323797", "aliases": ["(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity"], "types": ["T044"], "canonical_name": "isocitrate epimerase activity", "definition": "Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate. [EC:5.1.2.6, RHEA:10820]"}
{"concept_id": "C1323798", "aliases": ["lactic acid racemase activity", "hydroxyacid racemase activity", "lacticoracemase activity"], "types": ["T044"], "canonical_name": "lactate racemase activity", "definition": "Catalysis of the reaction: (S)-lactate = (R)-lactate. [EC:5.1.2.1, RHEA:10960]"}
{"concept_id": "C1323799", "aliases": ["tartaric racemase activity"], "types": ["T044"], "canonical_name": "tartrate epimerase activity", "definition": "Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate. [EC:5.1.2.5, RHEA:22212]"}
{"concept_id": "C1323800", "aliases": ["16-hydroxysteroid 16-epimerase activity"], "types": ["T044"], "canonical_name": "16-hydroxysteroid epimerase activity", "definition": "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid. [EC:5.1.99.2, MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN]"}
{"concept_id": "C1323801", "aliases": [], "types": ["T044"], "canonical_name": "allantoin racemase activity", "definition": "Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin. [EC:5.1.99.3, RHEA:10804]"}
{"concept_id": "C1323803", "aliases": ["phosphoinositide 3-kinase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase activity", "definition": "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. [GOC:bf, PMID:10209156, PMID:9255069]"}
{"concept_id": "C1323804", "aliases": ["phosphatidylinositol-3,4-bisphosphate 5-kinase activity", "ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity", "ATP:1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 5-phosphotransferase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol-4,5-bisphosphate 3-kinase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). [EC:2.7.1.153, RHEA:21292]"}
{"concept_id": "C1323805", "aliases": ["reduced diphosphopyridine nucleotide kinase activity", "reduced nicotinamide adenine dinucleotide kinase (phosphorylating)", "DPNH kinase activity", "ATP:NADH 2'-phosphotransferase activity"], "types": ["T044"], "canonical_name": "NADH kinase activity", "definition": "Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH. [EC:2.7.1.86, RHEA:12260]"}
{"concept_id": "C1323806", "aliases": ["GTP:AMP phosphotransferase", "nucleoside-triphosphate:AMP phosphotransferase activity", "nucleoside triphosphate-adenosine monophosphate transphosphorylase activity", "nucleoside triphosphate adenylate kinase activity", "nucleoside-triphosphate-adenylate kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP. [EC:2.7.4.10]", "canonical_name": "isozyme 3 of adenylate kinase activity"}
{"concept_id": "C1323807", "aliases": ["JUNKKKK activity"], "types": ["T044"], "canonical_name": "JUN kinase kinase kinase kinase activity", "definition": "Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs). [GOC:bf]"}
{"concept_id": "C1323809", "aliases": ["geranyl-CoA carboxylase activity", "geranoyl-CoA:carbon-dioxide ligase (ADP-forming)", "geranoyl coenzyme A carboxylase activity"], "types": ["T044"], "canonical_name": "geranoyl-CoA carboxylase activity", "definition": "Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H(+) + phosphate. [EC:6.4.1.5, RHEA:17701]"}
{"concept_id": "C1323810", "aliases": ["methylcrotonyl coenzyme A carboxylase activity", "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)", "MCCC activity", "beta-methylcrotonyl coenzyme A carboxylase activity", "beta-methylcrotonyl CoA carboxylase activity", "methylcrotonyl-CoA carboxylase activity", "beta-methylcrotonyl-CoA carboxylase activity"], "types": ["T044"], "canonical_name": "methylcrotonoyl-CoA carboxylase activity", "definition": "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate. [EC:6.4.1.4, RHEA:13589]"}
{"concept_id": "C1323811", "aliases": ["4-methylene-L-glutamate:ammonia ligase (AMP-forming)", "4-methyleneglutamine synthetase activity"], "types": ["T044"], "canonical_name": "4-methyleneglutamate-ammonia ligase activity", "definition": "Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH(4)(+) = 4-methylene-L-glutamine + AMP + diphosphate + 2 H(+). [EC:6.3.1.7, RHEA:13853]"}
{"concept_id": "C1323812", "aliases": ["asparagine synthetase (adenosine diphosphate-forming)", "L-aspartate:ammonia ligase (ADP-forming)", "asparagine synthetase (ADP-forming) activity"], "types": ["T044"], "canonical_name": "aspartate-ammonia ligase (ADP-forming) activity", "definition": "Catalysis of the reaction: L-aspartate + ATP + NH(4)(+) = L-asparagine + ADP + 2 H(+) + phosphate. [EC:6.3.1.4, RHEA:14197]"}
{"concept_id": "C1323813", "aliases": ["N5-ethyl-L-glutamine synthetase activity", "N(5)-ethyl-L-glutamine synthetase activity", "L-glutamate:ethylamine ligase (ADP-forming)", "N5-ethylglutamine synthetase activity", "theanine synthetase activity"], "types": ["T044"], "canonical_name": "glutamate-ethylamine ligase activity", "definition": "Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H(+) + phosphate. [EC:6.3.1.6, RHEA:20525]"}
{"concept_id": "C1323814", "aliases": ["nicotinamide adenine dinucleotide synthetase activity", "diphosphopyridine nucleotide synthetase activity", "NAD+ synthetase activity", "deamido-NAD+:ammonia ligase (AMP-forming)", "NAD synthase activity", "NAD+ synthase activity", "NAD synthase (AMP-forming)", "NAD(+) synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. [EC:6.3.1.5]", "canonical_name": "NAD synthetase activity"}
{"concept_id": "C1323815", "aliases": ["TSR synthetase activity", "glutathionylspermidine:glutathione ligase (ADP-forming)"], "types": ["T044"], "canonical_name": "trypanothione synthase activity", "definition": "Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate. [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN]"}
{"concept_id": "C1323816", "aliases": ["N-(2,3-dihydroxybenzoyl)-serine synthetase activity", "2,3-dihydroxybenzoate:L-serine ligase activity", "2,3-dihydroxybenzoylserine synthetase activity"], "types": ["T044"], "canonical_name": "2,3-dihydroxybenzoate-serine ligase activity", "definition": "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine. [EC:6.3.2.14, MetaCyc:1,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN]"}
{"concept_id": "C1323817", "aliases": ["citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)", "citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)"], "types": ["T044"], "canonical_name": "aerobactin synthase activity", "definition": "Catalysis of the reaction: 2 N(6)-acetyl-N(6)-hydroxy-L-lysine + 4 ATP + citrate + 2 H(2)O = 4 ADP + aerobactin + 8 H(+) + 4 phosphate. [RHEA:11760]"}
{"concept_id": "C1323818", "aliases": ["carnosine-homocarnosine synthetase activity", "L-histidine:beta-alanine ligase (AMP-forming)", "carnosine-anserine synthetase activity", "carnosine synthetase activity", "homocarnosine-carnosine synthetase activity"], "types": ["T044"], "canonical_name": "carnosine synthase activity", "definition": "Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine. [EC:6.3.2.11, MetaCyc:CARNOSINE-SYNTHASE-RXN]"}
{"concept_id": "C1323819", "aliases": ["D-alanylalanylpoly(phosphoglycerol) synthetase activity", "D-alanine-membrane acceptor-ligase activity", "D-alanine [D-alanyl carrier protein] ligase activity", "D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity", "D-alanine:membrane-acceptor ligase activity", "D-alanine-D-alanyl carrier protein ligase activity", "D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)"], "types": ["T044"], "canonical_name": "D-alanine-alanyl-poly(glycerolphosphate) ligase activity", "definition": "Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP. [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN]"}
{"concept_id": "C1323820", "aliases": ["g-glutamylhistamine synthase activity", "gamma-glutaminylhistamine synthetase activity", "L-glutamate:histamine ligase activity", "gamma-GHA synthetase activity"], "types": ["T044"], "canonical_name": "gamma-glutamylhistamine synthase activity", "definition": "Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown. [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN]"}
{"concept_id": "C1323821", "aliases": ["beta-alanine specific hGSH synthetase activity", "gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)", "homoglutathione synthetase activity"], "types": ["T044"], "canonical_name": "homoglutathione synthase activity", "definition": "Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H(+) + phosphate. [EC:6.3.2.23, RHEA:17993]"}
{"concept_id": "C1323822", "aliases": ["indoleacetate-lysine ligase activity", "(indol-3-yl)acetate:L-lysine ligase (ADP-forming)", "IAA-lysine synthetase activity", "indoleacetate:L-lysine ligase (ADP-forming)", "N-(indole-3-acetyl)-L-lysine synthetase activity"], "types": ["T044"], "canonical_name": "indoleacetate-lysine synthetase activity", "definition": "Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H(+) + phosphate. [EC:6.3.2.20, RHEA:14857]"}
{"concept_id": "C1323823", "aliases": ["L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity", "L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)", "L-alpha-aminoadipyl-cysteinyl-valine synthetase activity"], "types": ["T044"], "canonical_name": "N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity", "definition": "Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H(2)O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H(+). [EC:6.3.2.26, RHEA:23196]"}
{"concept_id": "C1323824", "aliases": ["4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity", "SAICAR synthase activity", "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)", "PurC", "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity", "SAICARs activity", "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity", "phosphoribosylaminoimidazole-succinocarboxamide synthase activity", "SAICAR synthetase activity", "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity", "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity", "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity"], "types": ["T044"], "canonical_name": "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity", "definition": "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate. [EC:6.3.2.6, RHEA:22628]"}
{"concept_id": "C1323825", "aliases": ["kyotorphin-synthesizing enzyme activity", "kyotorphin synthase activity", "L-tyrosine:L-arginine ligase (AMP-forming)", "tyrosyl-arginine synthase activity", "kyotorphin synthetase activity"], "types": ["T044"], "canonical_name": "tyrosine-arginine ligase activity", "definition": "Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+). [EC:6.3.2.24, RHEA:15345]"}
{"concept_id": "C1323827", "aliases": ["UDP-N-acetylmuramyl:L-alanine ligase activity", "UDP-N-acetylmuramoylalanine synthetase activity", "UDP-MurNAc:L-alanine ligase activity", "uridine diphosphate N-acetylmuramate:L-alanine ligase activity", "UDPMurNAc-L-alanine synthetase activity", "UDP-acetylmuramyl-L-alanine synthetase activity", "UDP-N-acetylmuramoyl-L-alanine synthetase activity", "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)", "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity", "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity", "uridine diphospho-N-acetylmuramoylalanine synthetase activity"], "types": ["T044"], "canonical_name": "UDP-N-acetylmuramate-L-alanine ligase activity", "definition": "Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine. [EC:6.3.2.8, RHEA:23372]"}
{"concept_id": "C1323828", "aliases": ["UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity", "uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity", "UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity", "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)"], "types": ["T044"], "canonical_name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity", "definition": "Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine. [EC:6.3.2.7, RHEA:17969]"}
{"concept_id": "C1323829", "aliases": ["UDPacetylmuramoylpentapeptide synthetase activity", "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity", "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity", "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity", "UDP-MurNAc-pentapeptide synthetase activity", "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity", "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)", "uridine diphosphoacetylmuramoylpentapeptide synthetase activity", "UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity", "UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity", "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity", "UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity"], "types": ["T044"], "canonical_name": "UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity", "definition": "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP. [EC:6.3.2.10, MetaCyc:6.3.2.10-RXN]"}
{"concept_id": "C1323830", "aliases": ["aspartyl-tRNA(Asn) amidotransferase activity", "aspartyl-tRNAAsn amidotransferase activity", "Asp-tRNA(Asn) amidotransferase activity", "asparaginyl-tRNA synthase (glutamine-hydrolysing)", "aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)", "Asp-tRNAAsn amidotransferase activity", "Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)", "Asp-AdT activity"], "types": ["T044"], "canonical_name": "asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity", "definition": "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP. [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN]"}
{"concept_id": "C1323832", "aliases": ["dihydrofolate formyltransferase activity", "formate:dihydrofolate ligase (ADP-forming)", "formyl dihydrofolate synthase activity"], "types": ["T044"], "canonical_name": "formate-dihydrofolate ligase activity", "definition": "Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H(+) + phosphate. [EC:6.3.4.17, RHEA:24328]"}
{"concept_id": "C1323833", "aliases": ["L-glutamate:methylamine ligase (ADP-forming)", "gamma-glutamylmethylamide synthetase activity"], "types": ["T044"], "canonical_name": "glutamate-methylamine ligase activity", "definition": "Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H(+) + phosphate. [EC:6.3.4.12, RHEA:17117]"}
{"concept_id": "C1323834", "aliases": ["imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)", "5-phosphoribosylimidazoleacetate synthetase activity"], "types": ["T044"], "canonical_name": "imidazoleacetate-phosphoribosyldiphosphate ligase activity", "definition": "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H(+) + phosphate. [EC:6.3.4.8, RHEA:16485]"}
{"concept_id": "C1323835", "aliases": ["ribose-5-phosphate:ammonia ligase (ADP-forming)", "5-phosphoribosylamine synthetase activity", "ribose 5-phosphate aminotransferase activity", "ammonia-ribose 5-phosphate aminotransferase activity"], "types": ["T044"], "canonical_name": "ribose-5-phosphate-ammonia ligase activity", "definition": "Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH(4)(+) = 5-phospho-D-ribosylamine + ADP + 2 H(+) + phosphate. [EC:6.3.4.7, RHEA:13777]"}
{"concept_id": "C1323836", "aliases": ["L-aspartate:tRNAAsx ligase (AMP-forming)", "aspartate-tRNAAsn ligase activity"], "types": ["T044"], "canonical_name": "aspartate-tRNA(Asn) ligase activity", "definition": "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP. [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN]"}
{"concept_id": "C1323838", "aliases": ["L-glutamate:tRNAGlx ligase (AMP-forming)", "glutamate-tRNAGln ligase activity"], "types": ["T044"], "canonical_name": "glutamate-tRNA(Gln) ligase activity", "definition": "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP. [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN]"}
{"concept_id": "C1323839", "aliases": ["L-lysine:tRNAPyl ligase (AMP-forming)", "lysine-tRNAPyl ligase activity"], "types": ["T044"], "canonical_name": "lysine-tRNA(Pyl) ligase activity", "definition": "Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP. [MetaCyc:6.1.1.25-RXN]"}
{"concept_id": "C1323840", "aliases": ["2-furoate:CoA ligase (AMP-forming)", "2-furoyl coenzyme A synthetase activity"], "types": ["T044"], "canonical_name": "2-furoate-CoA ligase activity", "definition": "Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H(+). [EC:6.2.1.31, RHEA:19269]"}
{"concept_id": "C1323842", "aliases": ["3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)", "3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity", "3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity", "DHCA-CoA ligase activity"], "types": ["T044"], "canonical_name": "3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity", "definition": "Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP. [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN]"}
{"concept_id": "C1323843", "aliases": ["acetoacetyl-CoA synthetase activity", "acetoacetate:CoA ligase (AMP-forming)"], "types": ["T044"], "canonical_name": "acetoacetate-CoA ligase activity", "definition": "Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+). [EC:6.2.1.16, RHEA:16117]"}
{"concept_id": "C1323844", "aliases": ["acid:CoA ligase (GDP-forming)", "acyl-CoA synthetase (GDP-forming) activity", "acyl coenzyme A synthetase (guanosine diphosphate forming)"], "types": ["T044"], "canonical_name": "acid-CoA ligase (GDP-forming) activity", "definition": "Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H(+) + phosphate. [RHEA:10968]"}
{"concept_id": "C1323845", "aliases": ["arachidonate:CoA ligase (AMP-forming)", "arachidonoyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "arachidonate-CoA ligase activity", "definition": "Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). [RHEA:19713]"}
{"concept_id": "C1323846", "aliases": ["biotin CoA synthetase activity", "biotinyl-CoA synthetase activity", "biotin:CoA ligase (AMP-forming)", "biotinyl coenzyme A synthetase activity"], "types": ["T044"], "canonical_name": "biotin-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA. [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN]"}
{"concept_id": "C1323847", "aliases": ["L-(+)-3-hydroxybutyryl CoA ligase activity", "short-chain acyl-CoA synthetase activity", "fatty acyl coenzyme A synthetase activity", "butanoate:CoA ligase (AMP-forming)", "medium chain acyl-CoA synthetase activity", "butyrate-CoA ligase activity", "butyryl-coenzyme A synthetase activity", "acyl-activating enzyme activity", "fatty acid thiokinase (medium chain) activity", "fatty acid activating enzyme"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA. [EC:6.2.1.2, MetaCyc:BUTYRATE--COA-LIGASE-RXN]", "canonical_name": "butyryl-CoA synthetase activity"}
{"concept_id": "C1323848", "aliases": ["3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity", "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity", "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity", "choloyl-CoA synthetase activity", "cholate thiokinase activity", "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity", "choloyl coenzyme A synthetase activity", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity", "cholate:CoA ligase (AMP-forming)", "cholyl-CoA synthetase activity", "cholic acid:CoA ligase activity", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity", "cholic thiokinase activity", "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity", "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity"], "types": ["T044"], "canonical_name": "cholate-CoA ligase activity", "definition": "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. [EC:6.2.1.7]"}
{"concept_id": "C1323849", "aliases": ["citrate thiokinase activity", "citryl-CoA synthetase activity", "citrate:CoA ligase activity", "citrate:CoA ligase (ADP-forming)"], "types": ["T044"], "canonical_name": "citrate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H(+) + phosphate. [EC:6.2.1.18, RHEA:21472]"}
{"concept_id": "C1323850", "aliases": ["omega-dicarboxylate:CoA ligase (AMP-forming)", "carboxylyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "dicarboxylate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA. [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN]"}
{"concept_id": "C1323851", "aliases": ["glutaryl-CoA synthetase activity", "glutaryl coenzyme A synthetase activity", "glutarate:CoA ligase (ADP-forming)"], "types": ["T044"], "canonical_name": "glutarate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H(+) + phosphate. [EC:6.2.1.6, RHEA:14169]"}
{"concept_id": "C1323853", "aliases": ["malate:CoA ligase (ADP-forming)", "malyl-CoA synthetase activity", "malyl coenzyme A synthetase activity"], "types": ["T044"], "canonical_name": "malate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA. [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN]"}
{"concept_id": "C1323854", "aliases": ["oxalyl coenzyme A synthetase activity", "oxalyl-CoA synthetase activity", "oxalate:CoA ligase (AMP-forming)"], "types": ["T044"], "canonical_name": "oxalate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA. [RHEA:18293]"}
{"concept_id": "C1323855", "aliases": ["phenylacetyl-CoA ligase activity", "phenylacetyl-CoA ligase (AMP-forming)", "phenacyl coenzyme A synthetase activity", "phenylacetate:CoA ligase (AMP-forming)", "PA-CoA ligase activity"], "types": ["T044"], "canonical_name": "phenylacetate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H(+) + phenylacetyl-CoA. [EC:6.2.1.30, RHEA:20956]"}
{"concept_id": "C1323856", "aliases": ["phytanate:CoA ligase (AMP-forming)", "phytanoyl-CoA ligase activity"], "types": ["T044"], "canonical_name": "phytanate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA. [EC:6.2.1.24, RHEA:21380]"}
{"concept_id": "C1323857", "aliases": ["propionyl-CoA synthetase activity", "propanoate:CoA ligase (AMP-forming)"], "types": ["T044"], "canonical_name": "propionate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA. [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN]"}
{"concept_id": "C1323858", "aliases": ["trans-ferulate:CoASH ligase (ATP-hydrolysing)", "trans-feruloyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "trans-feruloyl-CoA synthase activity", "definition": "Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate. [PMID:22649270]"}
{"concept_id": "C1323859", "aliases": ["17alpha-hydroxyprogesterone acetaldehyde-lyase activity", "17alpha-hydroxyprogesterone aldolase activity", "17-alpha-hydroxyprogesterone acetaldehyde-lyase activity", "17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)", "C-17/C-20 lyase activity"], "types": ["T044"], "canonical_name": "17-alpha-hydroxyprogesterone aldolase activity", "definition": "Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. [EC:4.1.2.30, MetaCyc:4.1.2.30-RXN]"}
{"concept_id": "C1323860", "aliases": ["2-keto-3-deoxy-D-pentonate aldolase activity", "2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-D-pentonate aldolase activity", "definition": "Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate. [EC:4.1.2.28, RHEA:20609]"}
{"concept_id": "C1323861", "aliases": ["2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)", "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity", "2-keto-3-deoxy-D-xylonate aldolase activity", "2-keto-3-deoxy-L-pentonate aldolase activity"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-L-pentonate aldolase activity", "definition": "Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate. [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN]"}
{"concept_id": "C1323862", "aliases": ["2-dehydropantoate formaldehyde-lyase activity", "2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)", "ketopantoaldolase activity"], "types": ["T044"], "canonical_name": "2-dehydropantoate aldolase activity", "definition": "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde. [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN]"}
{"concept_id": "C1323863", "aliases": ["3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)", "KDOaldolase activity", "2-keto-3-deoxyoctonate aldolase activity", "3-deoxyoctulosonic aldolase activity", "2-keto-3-deoxyoctonic aldolase activity", "3-deoxy-D-manno-octulosonate D-arabinose-lyase activity", "3-deoxy-D-manno-octulosonic aldolase activity"], "types": ["T044"], "canonical_name": "3-deoxy-D-manno-octulosonate aldolase activity", "definition": "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate. [EC:4.1.2.23, RHEA:23340]"}
{"concept_id": "C1323864", "aliases": ["phospho-5-keto-2-deoxygluconate aldolase activity", "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity", "phospho-5-dehydro-2-deoxygluconate aldolase activity", "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)"], "types": ["T044"], "canonical_name": "5-dehydro-2-deoxyphosphogluconate aldolase activity", "definition": "Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate. [EC:4.1.2.29, RHEA:13177]"}
{"concept_id": "C1323866", "aliases": ["benzaldehyde lyase activity", "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)", "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity", "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity", "diphenylethanone benzaldehyde-lyase activity"], "types": ["T044"], "canonical_name": "benzoin aldolase activity", "definition": "Catalysis of the reaction: benzoin = 2 benzaldehyde. [EC:4.1.2.38, RHEA:21460]"}
{"concept_id": "C1323867", "aliases": ["N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)", "N,N-dimethylaniline-N-oxide formaldehyde-lyase activity", "microsomal N-oxide dealkylase activity"], "types": ["T044"], "canonical_name": "dimethylaniline-N-oxide aldolase activity", "definition": "Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde. [EC:4.1.2.24, RHEA:19321]"}
{"concept_id": "C1323868", "aliases": ["D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity", "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)"], "types": ["T044"], "canonical_name": "fructose-6-phosphate phosphoketolase activity", "definition": "Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O. [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN]"}
{"concept_id": "C1323869", "aliases": ["(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)", "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity"], "types": ["T044"], "canonical_name": "fucosterol-epoxide lyase activity", "definition": "Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol. [EC:4.1.2.33, RHEA:10884]"}
{"concept_id": "C1323870", "aliases": ["(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)", "sorghum hydroxynitrile lyase activity", "(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity"], "types": ["T044"], "canonical_name": "hydroxymandelonitrile lyase activity", "definition": "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate. [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN]"}
{"concept_id": "C1323871", "aliases": ["2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)", "hydroxynitrile lyase activity", "acetone-cyanhydrin lyase activity", "(S)-acetone-cyanohydrin lyase activity", "2-hydroxyisobutyronitrile acetone-lyase activity", "acetone-cyanohydrin lyase activity", "alpha-hydroxynitrile lyase activity", "acetone-cyanohydrin acetone-lyase activity", "oxynitrilase activity", "acetone-cyanohydrin acetone-lyase (cyanide-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone. [GOC:mah, PMID:3377504]", "canonical_name": "hydroxynitrilase activity"}
{"concept_id": "C1323872", "aliases": ["erythrose-1-phosphate synthase activity", "phosphoketotetrose aldolase activity", "erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)", "erythrulose-1-phosphate synthetase activity", "erythrulose-1-phosphate formaldehyde-lyase activity"], "types": ["T044"], "canonical_name": "ketotetrose-phosphate aldolase activity", "definition": "Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate. [EC:4.1.2.2, RHEA:20932]"}
{"concept_id": "C1323873", "aliases": ["(S)-lactate acetaldehyde-lyase activity", "lactate synthase activity", "(S)-lactate acetaldehyde-lyase (formate-forming)"], "types": ["T044"], "canonical_name": "lactate aldolase activity", "definition": "Catalysis of the reaction: (S)-lactate = acetaldehyde + formate. [EC:4.1.2.36, RHEA:17909]"}
{"concept_id": "C1323874", "aliases": ["L-threo-3-phenylserine benzaldehyde-lyase activity", "L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)"], "types": ["T044"], "canonical_name": "phenylserine aldolase activity", "definition": "Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine. [EC:4.1.2.26, RHEA:21712]"}
{"concept_id": "C1323875", "aliases": ["D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)", "xylulose-5-phosphate phosphoketolase activity", "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity"], "types": ["T044"], "canonical_name": "phosphoketolase activity", "definition": "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O. [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN]"}
{"concept_id": "C1323876", "aliases": ["4-hydroxy-3-hexanone propanal-lyase activity", "4-hydroxy-3-hexanone propanal-lyase (propanal-forming)", "4-hydroxy-3-hexanone aldolase activity"], "types": ["T044"], "canonical_name": "propioin synthase activity", "definition": "Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal. [EC:4.1.2.35, RHEA:11100]"}
{"concept_id": "C1323877", "aliases": ["trimethylamine N-oxide formaldehyde-lyase activity", "trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)", "trimethylamine N-oxide aldolase activity", "trimethylamine-N-oxide formaldehyde-lyase activity", "trimethylamine N-oxide demethylase activity"], "types": ["T044"], "canonical_name": "trimethylamine-oxide aldolase activity", "definition": "Catalysis of the reaction: H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde. [EC:4.1.2.32, RHEA:20217]"}
{"concept_id": "C1323878", "aliases": ["3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)", "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)"], "types": ["T044"], "canonical_name": "vanillin synthase activity", "definition": "Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin. [RHEA:18725]"}
{"concept_id": "C1323879", "aliases": ["4-hydroxy-2-oxovalerate aldolase activity", "DmpG", "4-hydroxy-2-ketovalerate aldolase activity", "4-hydroxy-2-oxopentanoate pyruvate-lyase activity", "4-hydroxy-2-oxovalerate pyruvate-lyase activity", "HOA"], "types": ["T044"], "definition": "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. [EC:4.1.3.39, RHEA:22624]", "canonical_name": "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity"}
{"concept_id": "C1323880", "aliases": ["L-alanine-alpha-ketobutyrate aminotransferase activity", "2,2-dialkylglycine carboxy-lyase (amino-transferring)", "alpha-dialkyl amino acid transaminase activity", "2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)", "dialkylamino-acid decarboxylase (pyruvate)", "dialkyl amino acid (pyruvate) decarboxylase activity", "2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "2,2-dialkylglycine decarboxylase (pyruvate) activity", "definition": "Catalysis of the reaction: 2,2-dialkylglycine + H(+) + pyruvate = L-alanine + CO(2) + dialkyl ketone. [EC:4.1.1.64, RHEA:16073]"}
{"concept_id": "C1323881", "aliases": ["3,4-dihydroxyphthalate 2-decarboxylase activity", "3,4-dihydroxyphthalate carboxy-lyase activity", "3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)"], "types": ["T044"], "canonical_name": "3,4-dihydroxyphthalate decarboxylase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO(2). [EC:4.1.1.69, RHEA:18601]"}
{"concept_id": "C1323882", "aliases": ["3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)", "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity"], "types": ["T044"], "canonical_name": "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity", "definition": "Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 5-hydroxy-6-methylpyridine-3-carboxylate + CO(2). [EC:4.1.1.51, RHEA:13669]"}
{"concept_id": "C1323883", "aliases": ["beta-ketolaurate decarboxylase activity", "3-oxododecanoate carboxy-lyase (2-undecanone-forming)", "3-oxododecanoate carboxy-lyase activity", "beta-ketoacyl decarboxylase activity"], "types": ["T044"], "canonical_name": "3-oxolaurate decarboxylase activity", "definition": "Catalysis of the reaction: 3-oxolaurate + H(+) = 2-undecanone + CO(2). [EC:4.1.1.56, RHEA:13385]"}
{"concept_id": "C1323884", "aliases": ["4-carboxymuconolactone carboxy-lyase activity", "4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)", "4-carboxymonolactone carboxy-lyase activity", "gamma-4-carboxymuconolactone decarboxylase activity"], "types": ["T044"], "canonical_name": "4-carboxymuconolactone decarboxylase activity", "definition": "Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = 5-oxo-4,5-dihydro-2-furylacetate + CO(2). [EC:4.1.1.44, RHEA:23348]"}
{"concept_id": "C1323885", "aliases": ["4-hydroxyphenylpyruvate carboxy-lyase activity", "4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)"], "types": ["T044"], "canonical_name": "4-hydroxyphenylpyruvate decarboxylase activity", "definition": "Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO(2). [EC:4.1.1.80, RHEA:18697]"}
{"concept_id": "C1323886", "aliases": ["4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)", "4-oxalocrotonate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "4-oxalocrotonate decarboxylase activity", "definition": "Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate. [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN]"}
{"concept_id": "C1323887", "aliases": ["2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity", "2-oxo-5-guanidinopentanoate decarboxylase activity", "2-oxo-5-guanidinopentanoate carboxy-lyase activity", "alpha-ketoarginine decarboxylase activity", "2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)"], "types": ["T044"], "canonical_name": "5-guanidino-2-oxopentanoate decarboxylase activity", "definition": "Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO(2). [EC:4.1.1.75, RHEA:11340]"}
{"concept_id": "C1323888", "aliases": ["6-methylsalicylate carboxy-lyase activity", "6-methylsalicylate carboxy-lyase (3-cresol-forming)", "6-MSA decarboxylase activity", "6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity"], "types": ["T044"], "canonical_name": "6-methylsalicylate decarboxylase activity", "definition": "Catalysis of the reaction: 6-methylsalicylate + H(+) = 3-cresol + CO(2). [EC:4.1.1.52, RHEA:23112]"}
{"concept_id": "C1323889", "aliases": ["acetoacetate carboxy-lyase (acetone-forming)", "acetoacetate carboxy-lyase activity", "acetoacetic acid decarboxylase activity"], "types": ["T044"], "canonical_name": "acetoacetate decarboxylase activity", "definition": "Catalysis of the reaction: acetoacetate + H(+) = acetone + CO(2). [EC:4.1.1.4, RHEA:19729]"}
{"concept_id": "C1323890", "aliases": ["alpha-acetolactate decarboxylase activity", "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "acetolactate decarboxylase activity", "definition": "Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2. [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN]"}
{"concept_id": "C1323891", "aliases": ["acetylenedicarboxylate carboxy-lyase (pyruvate-forming)", "acetylenedicarboxylate hydrase activity", "acetylenedicarboxylate hydratase activity", "acetylenedicarboxylate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "acetylenedicarboxylate decarboxylase activity", "definition": "Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate. [EC:4.1.1.78]"}
{"concept_id": "C1323892", "aliases": ["cis-aconitic decarboxylase activity", "cis-aconitate carboxy-lyase activity", "aconitate decarboxylase activity", "CAD activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate. [EC:4.1.1.6, RHEA:15253]", "canonical_name": "cis-aconitate carboxy-lyase (itaconate-forming)"}
{"concept_id": "C1323893", "aliases": ["aminobenzoate carboxy-lyase (aniline-forming)", "aminobenzoate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "aminobenzoate decarboxylase activity", "definition": "Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2. [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN]"}
{"concept_id": "C1323894", "aliases": ["2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity", "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity", "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)", "ACMSD activity", "picolinic acid decarboxylase activity", "picolinic acid carboxylase activity", "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity", "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity"], "types": ["T044"], "canonical_name": "aminocarboxymuconate-semialdehyde decarboxylase activity", "definition": "Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2). [EC:4.1.1.45, RHEA:16557]"}
{"concept_id": "C1323895", "aliases": ["AMDase activity", "2-aryl-2-methylmalonate carboxy-lyase activity", "arylmalonate decarboxylase activity", "2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO(2). [EC:4.1.1.76, RHEA:20513]", "canonical_name": "AMDASE"}
{"concept_id": "C1323896", "aliases": ["aminomalonic decarboxylase activity", "L-aspartate beta-decarboxylase activity", "L-aspartate 4-carboxy-lyase activity", "desulfinase activity", "aspartate beta-decarboxylase activity", "aspartic beta-decarboxylase activity", "aspartate omega-decarboxylase activity", "cysteine sulfinic desulfinase activity", "L-aspartate 4-carboxy-lyase (L-alanine-forming)", "L-cysteine sulfinate acid desulfinase activity", "aspartic omega-decarboxylase activity"], "types": ["T044"], "canonical_name": "aspartate 4-decarboxylase activity", "definition": "Catalysis of the reaction: L-aspartate = L-alanine + CO2. [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN]"}
{"concept_id": "C1323897", "aliases": ["benzoylformate carboxy-lyase (benzaldehyde-forming)", "benzoylformate carboxy-lyase activity", "phenylglyoxylate decarboxylase activity"], "types": ["T044"], "canonical_name": "benzoylformate decarboxylase activity", "definition": "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2. [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN]"}
{"concept_id": "C1323898", "aliases": ["BCKA", "(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity", "branched-chain keto acid decarboxylase activity", "(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)", "branched-chain alpha-keto acid decarboxylase activity", "branched-chain oxo acid decarboxylase activity"], "types": ["T044"], "canonical_name": "branched-chain-2-oxoacid decarboxylase activity", "definition": "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2). [EC:4.1.1.72, RHEA:21108]"}
{"concept_id": "C1323899", "aliases": ["carnitine carboxy-lyase (2-methylcholine-forming)", "carnitine carboxy-lyase activity"], "types": ["T044"], "canonical_name": "carnitine decarboxylase activity", "definition": "Catalysis of the reaction: carnitine + H(+) = 2-methylcholine + CO(2). [EC:4.1.1.42, RHEA:21576]"}
{"concept_id": "C1323900", "aliases": ["3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)", "3-dehydro-L-gulonate carboxy-lyase activity", "3-keto-L-gulonate decarboxylase activity", "keto-L-gulonate decarboxylase activity"], "types": ["T044"], "canonical_name": "dehydro-L-gulonate decarboxylase activity", "definition": "Catalysis of the reaction: 3-dehydro-L-gulonate + H(+) = L-xylulose + CO(2). [EC:4.1.1.34, RHEA:11084]"}
{"concept_id": "C1323901", "aliases": ["dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)", "dihydroxyfumarate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "dihydroxyfumarate decarboxylase activity", "definition": "Catalysis of the reaction: dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2). [EC:4.1.1.54, RHEA:13845]"}
{"concept_id": "C1323902", "aliases": ["2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)", "gentisate carboxy-lyase activity", "2,5-dihydroxybenzoate decarboxylase activity"], "types": ["T044"], "canonical_name": "gentisate decarboxylase activity", "definition": "Catalysis of the reaction: 2,5-dihydroxybenzoate + H(+) = CO(2) + hydroquinone. [EC:4.1.1.62, RHEA:21312]"}
{"concept_id": "C1323903", "aliases": ["3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)", "3-hydroxy-L-glutamate 1-carboxy-lyase activity"], "types": ["T044"], "canonical_name": "hydroxyglutamate decarboxylase activity", "definition": "Catalysis of the reaction: 3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO(2). [EC:4.1.1.16, RHEA:14073]"}
{"concept_id": "C1323904", "aliases": ["hydroxypyruvate carboxy-lyase activity", "hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)"], "types": ["T044"], "canonical_name": "hydroxypyruvate decarboxylase activity", "definition": "Catalysis of the reaction: 3-hydroxypyruvate + H(+) = CO(2) + glycolaldehyde. [EC:4.1.1.40, RHEA:20561]"}
{"concept_id": "C1323905", "aliases": ["3-(indol-3-yl)pyruvate carboxy-lyase activity", "indol-3-yl-pyruvate carboxy-lyase activity", "indole-3-pyruvate decarboxylase activity"], "types": ["T044"], "canonical_name": "indolepyruvate decarboxylase activity", "definition": "Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde. [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN]"}
{"concept_id": "C1323906", "aliases": ["malonyl-CoA carboxy-lyase (acetyl-CoA-forming)", "malonyl coenzyme A decarboxylase activity", "malonyl-CoA carboxy-lyase activity"], "types": ["T044"], "canonical_name": "malonyl-CoA decarboxylase activity", "definition": "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN]"}
{"concept_id": "C1323907", "aliases": ["L-methionine decarboxylase activity", "L-methionine carboxy-lyase activity", "L-methionine carboxy-lyase (3-methylthiopropanamine-forming)"], "types": ["T044"], "canonical_name": "methionine decarboxylase activity", "definition": "Catalysis of the reaction: L-methionine + H(+) = 3-methylthiopropanamine + CO(2). [EC:4.1.1.57, RHEA:17757]"}
{"concept_id": "C1323908", "aliases": ["2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)", "2,3-DHBA decarboxylase activity", "2,3-dihydroxybenzoate decarboxylase activity", "o-pyrocatechuate decarboxylase activity", "2,3-dihydroxybenzoate carboxy-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-dihydroxybenzoate + H(+) = catechol + CO(2). [EC:4.1.1.46, RHEA:21492]", "canonical_name": "2,3-dihydroxybenzoic acid decarboxylase activity"}
{"concept_id": "C1323909", "aliases": ["orsellinate carboxy-lyase (orcinol-forming)", "orsellinate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "orsellinate decarboxylase activity", "definition": "Catalysis of the reaction: o-orsellinate + H(+) = CO(2) + orcinol. [EC:4.1.1.58, RHEA:16733]"}
{"concept_id": "C1323910", "aliases": ["N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity", "pantothenylcysteine decarboxylase activity", "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)", "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity"], "types": ["T044"], "canonical_name": "pantothenoylcysteine decarboxylase activity", "definition": "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H(+) = (R)-pantetheine + CO(2). [EC:4.1.1.30, RHEA:15077]"}
{"concept_id": "C1323912", "aliases": ["phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)", "phenylpyruvate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "phenylpyruvate decarboxylase activity", "definition": "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2. [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN]"}
{"concept_id": "C1323913", "aliases": ["protocatechuate carboxy-lyase activity", "3,4-dihydroxybenzoate decarboxylase activity", "3,4-dihydrobenzoate decarboxylase activity", "3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)"], "types": ["T044"], "canonical_name": "protocatechuate decarboxylase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxybenzoate + H(+) = catechol + CO(2). [EC:4.1.1.63, RHEA:22416]"}
{"concept_id": "C1323914", "aliases": ["stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)", "stipitatonate carboxy-lyase (decyclizing)"], "types": ["T044"], "canonical_name": "stipitatonate decarboxylase activity", "definition": "Catalysis of the reaction: H(2)O + stipitatonate = CO(2) + H(+) + stipitatate. [EC:4.1.1.60, RHEA:13885]"}
{"concept_id": "C1323915", "aliases": ["sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)", "sulphopyruvate decarboxylase activity", "sulfopyruvate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "sulfopyruvate decarboxylase activity", "definition": "Catalysis of the reaction: 3-sulfopyruvate + H(+) = CO(2) + sulfoacetaldehyde. [EC:4.1.1.79, RHEA:20948]"}
{"concept_id": "C1323916", "aliases": ["(R,R)-tartrate carboxy-lyase activity", "(R,R)-tartrate carboxy-lyase (D-glycerate-forming)"], "types": ["T044"], "canonical_name": "tartrate decarboxylase activity", "definition": "Catalysis of the reaction: L-tartrate + H(+) = D-glycerate + CO(2). [EC:4.1.1.73, RHEA:13317]"}
{"concept_id": "C1323917", "aliases": ["UDP-galacturonic acid decarboxylase activity", "UDP-D-galacturonate carboxy-lyase activity", "UDPGalUA carboxy lyase activity", "UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)", "UDPgalacturonate decarboxylase activity"], "types": ["T044"], "canonical_name": "UDP-galacturonate decarboxylase activity", "definition": "Catalysis of the reaction: H(+) + UDP-alpha-D-galacturonate = CO(2) + UDP-L-arabinose. [EC:4.1.1.67, RHEA:19725]"}
{"concept_id": "C1323918", "aliases": ["UDP-glucuronic acid decarboxylase activity", "UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)", "UDPglucuronate decarboxylase activity", "uridine-diphosphoglucuronate decarboxylase activity", "UDP-D-glucuronate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "UDP-glucuronate decarboxylase activity", "definition": "Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose. [EC:4.1.1.35, RHEA:23916]"}
{"concept_id": "C1323919", "aliases": ["uracil-5-carboxylate carboxy-lyase (uracil-forming)", "uracil-5-carboxylic acid decarboxylase activity", "uracil-5-carboxylate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "uracil-5-carboxylate decarboxylase activity", "definition": "Catalysis of the reaction: H(+) + uracil 5-carboxylate = CO(2) + uracil. [EC:4.1.1.66, RHEA:17685]"}
{"concept_id": "C1323920", "aliases": ["L-valine carboxy-lyase (2-methylpropanamine-forming)", "leucine decarboxylase activity", "L-valine carboxy-lyase activity"], "types": ["T044"], "canonical_name": "valine decarboxylase activity", "definition": "Catalysis of the reaction: L-valine + H(+) = 2-methylpropanamine + CO(2). [EC:4.1.1.14, RHEA:18989]"}
{"concept_id": "C1323921", "aliases": ["beta-tyrosinase activity", "L-tyrosine phenol-lyase (deaminating; pyruvate-forming)", "tyrosine phenol-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-tyrosine + H(2)O = NH(4)(+) + phenol + pyruvate. [EC:4.1.99.2, RHEA:21704]", "canonical_name": "L-tyrosine phenol-lyase (deaminating)"}
{"concept_id": "C1323922", "aliases": ["(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity", "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)"], "types": ["T044"], "canonical_name": "(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity", "definition": "Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone. [EC:4.1.3.35, RHEA:23868]"}
{"concept_id": "C1323923", "aliases": ["(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)", "(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity", "2,3-dimethylmalate pyruvate-lyase activity"], "types": ["T044"], "canonical_name": "2,3-dimethylmalate lyase activity", "definition": "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate. [EC:4.1.3.32, RHEA:10472]"}
{"concept_id": "C1323924", "aliases": ["3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity", "hydroxyisohexenylglutaryl-CoA:acetatelyase activity", "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)", "beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity", "3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity", "3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity"], "types": ["T044"], "canonical_name": "3-hydroxy-3-isohexenylglutaryl-CoA lyase activity", "definition": "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H(+) = 7-methyl-3-oxooct-6-enoyl-CoA + acetate. [EC:4.1.3.26, RHEA:23084]"}
{"concept_id": "C1323925", "aliases": ["erythro-beta-hydroxyaspartate glycine-lyase activity", "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity", "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity", "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)", "erythro-beta-hydroxyaspartate aldolase activity"], "types": ["T044"], "canonical_name": "3-hydroxyaspartate aldolase activity", "definition": "Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate. [EC:4.1.3.14, RHEA:14377]"}
{"concept_id": "C1323926", "aliases": ["ADC synthase activity", "4-amino-4-deoxychorismate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. [EC:2.6.1.85, RHEA:11672]", "canonical_name": "chorismate:L-glutamine amido-ligase activity"}
{"concept_id": "C1323927", "aliases": ["4-hydroxy-4-methyl-2-ketoglutarate aldolase activity", "gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity", "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)", "pyruvate aldolase activity", "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity"], "types": ["T044"], "canonical_name": "4-hydroxy-4-methyl-2-oxoglutarate aldolase activity", "definition": "Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. [EC:4.1.3.17, MetaCyc:4.1.3.17-RXN]"}
{"concept_id": "C1323928", "aliases": ["(3S)-citramalate pyruvate-lyase (acetate-forming)", "(+)-citramalate pyruvate-lyase activity", "citramalic synthase activity", "citramalate synthetase activity", "(3S)-citramalate pyruvate-lyase activity", "citramalate pyruvate lyase activity", "(S)-citramalate lyase activity", "citramalate pyruvate-lyase activity"], "types": ["T044"], "canonical_name": "citramalate lyase activity", "definition": "Catalysis of the reaction: S-citramalate = acetate + pyruvate. [EC:4.1.3.22, RHEA:15545]"}
{"concept_id": "C1323929", "aliases": ["(3S)-citramalyl-CoA pyruvate-lyase activity", "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)", "(3S)-citramalyl-CoA lyase activity", "citramalyl-CoA lyase activity", "citramalyl coenzyme A lyase activity", "(+)-CMA-CoA lyase activity"], "types": ["T044"], "canonical_name": "(S)-citramalyl-CoA lyase activity", "definition": "Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate. [EC:4.1.3.25, RHEA:22612]"}
{"concept_id": "C1323930", "aliases": ["malyl-coenzyme A lyase activity", "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)", "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity"], "types": ["T044"], "canonical_name": "malyl-CoA lyase activity", "definition": "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate. [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN]"}
{"concept_id": "C1323931", "aliases": ["3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)", "3-oxalomalate glyoxylate-lyase activity"], "types": ["T044"], "canonical_name": "oxalomalate lyase activity", "definition": "Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate. [EC:4.1.3.13, RHEA:22032]"}
{"concept_id": "C1323932", "aliases": ["L-2-amino-4-chloro-4-pentenoate dehalogenase activity", "L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)", "L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)"], "types": ["T044"], "canonical_name": "L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity", "definition": "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H(2)O = 2-oxopent-4-enoate + chloride + H(+) + NH(4)(+). [EC:4.5.1.4, RHEA:11620]"}
{"concept_id": "C1323933", "aliases": ["S-carboxymethyl-L-cysteine synthase activity", "3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)", "3-chloro-L-alanine chloride-lyase (adding thioglycolate)"], "types": ["T044"], "canonical_name": "S-carboxymethylcysteine synthase activity", "definition": "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H(+). [EC:4.5.1.5, RHEA:22868]"}
{"concept_id": "C1323934", "aliases": ["DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)", "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)", "DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)"], "types": ["T044"], "canonical_name": "purine imidazole-ring cyclase activity", "definition": "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O. [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN]"}
{"concept_id": "C1323935", "aliases": ["(S)-ureidoglycolate urea-lyase (glyoxylate-forming)", "(S)-ureidoglycolate urea-lyase activity"], "types": ["T044"], "canonical_name": "ureidoglycolate lyase activity", "definition": "Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea. [EC:4.3.2.3, RHEA:11304]"}
{"concept_id": "C1323936", "aliases": ["3-ketovalidoxylamine A C-N-lyase activity", "p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity", "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity"], "types": ["T044"], "canonical_name": "3-ketovalidoxylamine C-N-lyase activity", "definition": "Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H(+). [EC:4.3.3.1, RHEA:22768]"}
{"concept_id": "C1323937", "aliases": ["deacetylipecoside dopamine-lyase activity", "deacetylipecoside dopamine-lyase (secologanin-forming)"], "types": ["T044"], "canonical_name": "deacetylipecoside synthase activity", "definition": "Catalysis of the reaction: deacetylipecoside + H(2)O = dopamine + secologanin. [EC:4.3.3.4, RHEA:12296]"}
{"concept_id": "C1323938", "aliases": ["deacetylisoipecoside dopamine-lyase activity", "deacetylisoipecoside dopamine-lyase (secologanin-forming)"], "types": ["T044"], "canonical_name": "deacetylisoipecoside synthase activity", "definition": "Catalysis of the reaction: deacetylisoipecoside + H(2)O = dopamine + secologanin. [EC:4.3.3.3, RHEA:21756]"}
{"concept_id": "C1323939", "aliases": ["L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)", "L-3-aminobutyryl-CoA deaminase activity", "L-3-aminobutyryl-CoA ammonia-lyase activity"], "types": ["T044"], "canonical_name": "3-aminobutyryl-CoA ammonia-lyase activity", "definition": "Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH(4)(+). [EC:4.3.1.14, RHEA:10056]"}
{"concept_id": "C1323941", "aliases": ["b-alanyl-CoA ammonia-lyase activity", "beta-alanyl coenzyme A ammonia-lyase activity", "beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)"], "types": ["T044"], "canonical_name": "beta-alanyl-CoA ammonia-lyase activity", "definition": "Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3. [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN]"}
{"concept_id": "C1323942", "aliases": ["O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)", "O-carbamoyl-L-serine deaminase activity", "O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)", "carbamoylserine deaminase activity"], "types": ["T044"], "canonical_name": "carbamoyl-serine ammonia-lyase activity", "definition": "Catalysis of the reaction: O-carbamoyl-L-serine + H(2)O + H(+) = CO(2) + 2 NH(4)(+) + pyruvate. [EC:4.3.1.13, RHEA:15445]"}
{"concept_id": "C1323944", "aliases": ["erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)", "erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)", "erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity", "erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity", "erythro-3-hydroxyaspartate dehydratase activity", "erythro-beta-hydroxyaspartate dehydratase activity"], "types": ["T044"], "canonical_name": "erythro-3-hydroxyaspartate ammonia-lyase activity", "definition": "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid. [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN]"}
{"concept_id": "C1323945", "aliases": ["D-glucosaminic acid dehydrase activity", "aminodeoxygluconate dehydratase activity", "acetylenemonocarboxylic acid hydrase activity", "D-glucosaminate dehydratase activity", "2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity", "D-glucosaminate ammonia-lyase activity", "aminodeoxygluconate ammonia-lyase activity", "D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)", "2-amino-2-deoxy-D-gluconate ammonia-lyase activity", "glucosaminic dehydrase activity"], "types": ["T044"], "canonical_name": "glucosaminate ammonia-lyase activity", "definition": "Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3. [EC:4.3.1.9, MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN]"}
{"concept_id": "C1323946", "aliases": ["L-threo-3-methylaspartate ammonia-lyase activity", "L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)", "beta-methylaspartase activity", "3-methylaspartase activity"], "types": ["T044"], "canonical_name": "methylaspartate ammonia-lyase activity", "definition": "Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH(4)(+). [EC:4.3.1.2, RHEA:12829]"}
{"concept_id": "C1323947", "aliases": ["L-serine-O-sulfate ammonia-lyase (pyruvate-forming)", "serine-sulphate ammonia-lyase activity", "(L-SOS)lyase activity"], "types": ["T044"], "canonical_name": "serine-sulfate ammonia-lyase activity", "definition": "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate. [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN]"}
{"concept_id": "C1323948", "aliases": ["threo-3-hydroxyaspartate dehydratase activity", "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)", "threo-3-hydroxy-L-aspartate ammonia-lyase activity", "L-threo-3-hydroxyaspartate dehydratase activity"], "types": ["T044"], "canonical_name": "threo-3-hydroxyaspartate ammonia-lyase activity", "definition": "Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate. [EC:4.3.1.16, RHEA:12424]"}
{"concept_id": "C1323949", "aliases": ["D-cadinene synthase activity", "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)"], "types": ["T044"], "canonical_name": "(+)-delta-cadinene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene. [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN]"}
{"concept_id": "C1323950", "aliases": ["(-)-endo-fenchol cyclase activity", "geranyl pyrophosphate:(-)-endo-fenchol cyclase activity"], "types": ["T044"], "canonical_name": "(-)-endo-fenchol synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate + H(2)O = (-)-endo-fenchol + diphosphate. [EC:4.2.3.10, RHEA:20565]"}
{"concept_id": "C1323951", "aliases": ["(-)-(4S)-limonene synthase activity", "4S-(-)-limonene synthase activity", "geranyldiphosphate diphosphate lyase (limonene forming)"], "types": ["T044"], "canonical_name": "(4S)-limonene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate. [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN]"}
{"concept_id": "C1323952", "aliases": ["abietadiene cyclase activity", "copalyl-diphosphate diphosphate-lyase (cyclizing)", "(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)"], "types": ["T044"], "canonical_name": "abietadiene synthase activity", "definition": "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate. [EC:4.2.3.18, RHEA:13873]"}
{"concept_id": "C1323953", "aliases": ["geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)", "casbene synthetase activity", "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)"], "types": ["T044"], "canonical_name": "casbene synthase activity", "definition": "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate. [EC:4.2.3.8, RHEA:14901]"}
{"concept_id": "C1323954", "aliases": ["O-phosphoethanolamine-phospholyase activity", "O-phosphorylethanol-amine phospho-lyase activity", "ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)", "ethanolamine-phosphate phospho-lyase (deaminating)"], "types": ["T044"], "canonical_name": "ethanolamine-phosphate phospho-lyase activity", "definition": "Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate. [EC:4.2.3.2, RHEA:17889]"}
{"concept_id": "C1323955", "aliases": ["geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity"], "types": ["T044"], "canonical_name": "myrcene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene. [EC:4.2.3.15, RHEA:16965]"}
{"concept_id": "C1323956", "aliases": ["2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)", "pentalenene synthetase activity", "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)"], "types": ["T044"], "canonical_name": "pentalenene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene. [EC:4.2.3.7, RHEA:18081]"}
{"concept_id": "C1323958", "aliases": ["sabinene hydrate cyclase activity", "geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)"], "types": ["T044"], "canonical_name": "sabinene-hydrate synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate + H(2)O = diphosphate + sabinene hydrate. [EC:4.2.3.11, RHEA:19565]"}
{"concept_id": "C1323959", "aliases": ["geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)", "taxa-4(5),11(12)-diene synthase activity", "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)"], "types": ["T044"], "canonical_name": "taxadiene synthase activity", "definition": "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene. [EC:4.2.3.17, RHEA:20912]"}
{"concept_id": "C1323960", "aliases": [], "types": ["T044"], "canonical_name": "chondroitin ABC lyase activity", "definition": "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. [GOC:hjd]"}
{"concept_id": "C1323961", "aliases": ["exo-alpha-1,4-glucan lyase activity", "alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity", "alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity", "(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)", "exo-(1->4)-alpha-D-glucan lyase activity", "alpha-1,4-glucan exo-lyase activity"], "types": ["T044"], "canonical_name": "exo-(1,4)-alpha-D-glucan lyase activity", "definition": "Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose. [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN]"}
{"concept_id": "C1323962", "aliases": ["heparinase activity"], "types": ["T044"], "canonical_name": "heparin lyase activity", "definition": "Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends. [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN]"}
{"concept_id": "C1323963", "aliases": ["oligogalacturonate lyase activity", "OGTE", "unsaturated oligogalacturonate transeliminase activity"], "types": ["T044"], "canonical_name": "oligogalacturonide lyase activity", "definition": "Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate. [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN]"}
{"concept_id": "C1323964", "aliases": ["exopolygalacturonate lyase activity", "exopectate lyase activity", "pectate exo-lyase activity", "Exo-PATE activity", "PATE activity", "exopolygalacturonic acid-trans-eliminase activity", "exopectic acid transeliminase activity", "Exo-PGL activity", "(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity"], "types": ["T044"], "canonical_name": "pectate disaccharide-lyase activity", "definition": "Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin. [EC:4.2.2.9]"}
{"concept_id": "C1323965", "aliases": ["PL activity", "PMGL activity", "pectin methyltranseliminase activity", "(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity", "PNL activity", "pectolyase activity", "endo-pectin lyase activity", "polymethylgalacturonic transeliminase activity"], "types": ["T044"], "canonical_name": "pectin lyase activity", "definition": "Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends. [EC:4.2.2.10]"}
{"concept_id": "C1323966", "aliases": ["guluronate lyase activity", "polyguluronate-specific alginate lyase activity", "poly-alpha-L-guluronate lyase activity", "L-guluronate lyase activity", "poly(alpha-L-1,4-guluronide) exo-lyase activity", "L-guluronan lyase activity"], "types": ["T044"], "canonical_name": "poly(alpha-L-guluronate) lyase activity", "definition": "Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends. [EC:4.2.2.11]"}
{"concept_id": "C1323967", "aliases": [], "types": ["T044"], "canonical_name": "xanthan lyase activity", "definition": "Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain. [EC:4.2.2.12]"}
{"concept_id": "C1323968", "aliases": ["(R)-2-methylmalate hydro-lyase activity", "citramalate hydro-lyase activity", "citraconase activity", "(-)-citramalate hydro-lyase activity", "citraconate hydratase activity", "(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)"], "types": ["T044"], "canonical_name": "(R)-2-methylmalate dehydratase activity", "definition": "Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H(2)O. [EC:4.2.1.35, RHEA:22332]"}
{"concept_id": "C1323969", "aliases": ["mesaconate hydratase activity", "(+)-citramalic hydro-lyase activity", "(+)-citramalate hydro-lyase activity", "L-citramalate hydrolase activity", "(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)", "citramalate dehydratase activity", "(S)-2-methylmalate hydro-lyase activity", "mesaconate mesaconase activity", "mesaconase activity"], "types": ["T044"], "canonical_name": "(S)-2-methylmalate dehydratase activity", "definition": "Catalysis of the reaction: S-citramalate = H(2)O + mesaconate. [EC:4.2.1.34, RHEA:13529]"}
{"concept_id": "C1323970", "aliases": ["(S)-norlaudanosoline synthase activity", "4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)"], "types": ["T044"], "canonical_name": "(S)-norcoclaurine synthase activity", "definition": "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O. [EC:4.2.1.78]"}
{"concept_id": "C1323972", "aliases": ["16alpha-dehydroxylase activity", "16alpha-hydroxyprogesterone hydro-lyase activity", "16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)", "16-alpha-dehydroxylase activity", "16alpha-hydroxyprogesterone dehydratase activity", "hydroxyprogesterone dehydroxylase activity", "16alpha-hydroxyprogesterone dehydroxylase activity", "16-alpha-hydroxyprogesterone dehydroxylase activity"], "types": ["T044"], "canonical_name": "16-alpha-hydroxyprogesterone dehydratase activity", "definition": "Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone. [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN]"}
{"concept_id": "C1323973", "aliases": [], "types": ["T044"], "canonical_name": "16-dehydroprogesterone hydratase activity"}
{"concept_id": "C1323974", "aliases": ["2-keto-3-deoxy-L-arabinonate dehydratase activity", "2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)", "2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-L-arabinonate dehydratase activity", "definition": "Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O. [EC:4.2.1.43, RHEA:17201]"}
{"concept_id": "C1323975", "aliases": ["prpD", "2-methylcitrate hydro-lyase activity", "2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity"], "types": ["T044"], "canonical_name": "2-methylcitrate dehydratase activity", "definition": "Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O. [EC:4.2.1.79, RHEA:17725]"}
{"concept_id": "C1323976", "aliases": ["(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity"], "types": ["T044"], "canonical_name": "2-methylisocitrate dehydratase activity", "definition": "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H(2)O. [EC:4.2.1.99, RHEA:17941]"}
{"concept_id": "C1323977", "aliases": ["L-asparagine hydro-lyase activity", "beta-CNA nitrilase activity", "L-asparagine hydro-lyase (3-cyanoalanine-forming)", "beta-cyanoalanine hydratase activity", "beta-CNAla hydrolase activity", "beta-cyanoalanine hydrolase activity"], "types": ["T044"], "canonical_name": "3-cyanoalanine hydratase activity", "definition": "Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H(2)O + H(+). [EC:4.2.1.65, RHEA:15385]"}
{"concept_id": "C1323978", "aliases": ["3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity", "3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity", "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)", "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity", "beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity", "D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity", "beta-hydroxyoctanoyl thioester dehydratase activity", "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity", "3-hydroxyoctanoyl-ACP dehydratase activity", "beta-hydroxyoctanoyl-ACP-dehydrase activity", "D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity"], "types": ["T044"], "canonical_name": "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity", "definition": "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]. [PMID:8910376, RHEA:41844]"}
{"concept_id": "C1323979", "aliases": ["4-carboxy-2-oxohexenedioate hydratase activity", "gamma-oxalmesaconate hydratase activity", "4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity", "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity", "oxalmesaconate hydratase activity"], "types": ["T044"], "canonical_name": "4-oxalmesaconate hydratase activity", "definition": "Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(2)O. [EC:4.2.1.83, RHEA:17401]"}
{"concept_id": "C1323980", "aliases": ["5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity", "5alpha-hydroxysteroid dehydratase activity", "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)"], "types": ["T044"], "canonical_name": "5-alpha-hydroxysteroid dehydratase activity", "definition": "Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H(2)O. [EC:4.2.1.62, RHEA:22064]"}
{"concept_id": "C1323981", "aliases": ["D-4-deoxy-5-ketoglucarate hydro-lyase activity", "5-keto-4-deoxy-glucarate dehydratase activity", "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)", "deoxyketoglucarate dehydratase activity", "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)"], "types": ["T044"], "canonical_name": "5-dehydro-4-deoxyglucarate dehydratase activity", "definition": "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO(2) + H(2)O. [EC:4.2.1.41, RHEA:24608]"}
{"concept_id": "C1323983", "aliases": ["HPI"], "types": ["T044"], "definition": "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O. [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849]", "canonical_name": "allene oxide synthase activity"}
{"concept_id": "C1323984", "aliases": ["D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)", "D-arabinonate hydro-lyase activity"], "types": ["T044"], "canonical_name": "arabinonate dehydratase activity", "definition": "Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O. [EC:4.2.1.5, RHEA:21836]"}
{"concept_id": "C1323985", "aliases": ["(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)", "ATP-dependent H(4)NAD(P)OH dehydratase activity", "ATP-dependent H4NAD(P)OH dehydratase activity"], "types": ["T044"], "canonical_name": "ATP-dependent NAD(P)H-hydrate dehydratase activity", "definition": "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate. [PMID:3061454, RHEA:19017]"}
{"concept_id": "C1323986", "aliases": ["L-arogenate hydro-lyase (decarboxylating)", "carboxycyclohexadienyl dehydratase activity", "L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)"], "types": ["T044"], "canonical_name": "arogenate dehydratase activity", "definition": "Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2. [EC:4.2.1.91, MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN]"}
{"concept_id": "C1323987", "aliases": ["CDP-glucose 4,6-hydro-lyase activity", "CDPglucose 4,6-dehydratase activity", "CDPglucose 4,6-hydro-lyase activity", "cytidine diphosphoglucose oxidoreductase activity", "CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)"], "types": ["T044"], "canonical_name": "CDP-glucose 4,6-dehydratase activity", "definition": "Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O. [EC:4.2.1.45, RHEA:17153]"}
{"concept_id": "C1323988", "aliases": ["citrate hydro-lyase (cis-aconitate-forming) activity", "citrate hydro-lyase (cis-aconitate-forming)"], "types": ["T044"], "canonical_name": "citrate dehydratase activity", "definition": "Catalysis of the reaction: citrate = cis-aconitate + H2O. [EC:4.2.1.3]"}
{"concept_id": "C1323989", "aliases": ["beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity", "enoyl acyl carrier protein hydrase activity", "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity", "crotonoyl-[acyl-carrier protein] hydratase activity", "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity", "3-hydroxybutyryl acyl carrier protein dehydratase activity", "crotonoyl-acyl-carrier-protein hydratase activity", "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)", "beta-hydroxybutyryl acyl carrier protein dehydrase activity", "crotonoyl-ACP hydratase activity", "crotonyl acyl carrier protein hydratase activity"], "types": ["T044"], "canonical_name": "crotonoyl-[acyl-carrier-protein] hydratase activity", "definition": "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]. [EC:4.2.1.58, MetaCyc:4.2.1.58-RXN]"}
{"concept_id": "C1323990", "aliases": ["N-cyclohexylformamide hydro-lyase activity", "N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)", "isonitrile hydratase activity"], "types": ["T044"], "canonical_name": "cyclohexyl-isocyanide hydratase activity", "definition": "Catalysis of the reaction: N-cyclohexylformamide + H(+) = cyclohexyl isocyanide + H(2)O. [EC:4.2.1.103, RHEA:18197]"}
{"concept_id": "C1323991", "aliases": ["(S,S)-tartrate hydro-lyase activity", "D-tartrate dehydratase activity", "(S,S)-tartrate hydro-lyase (oxaloacetate-forming)"], "types": ["T044"], "canonical_name": "D(-)-tartrate dehydratase activity", "definition": "Catalysis of the reaction: D-tartrate = H(2)O + oxaloacetate. [EC:4.2.1.81, RHEA:18289]"}
{"concept_id": "C1323992", "aliases": ["D-fuconate hydratase activity", "D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)", "D-fuconate hydro-lyase activity"], "types": ["T044"], "canonical_name": "D-fuconate dehydratase activity", "definition": "Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H(2)O. [EC:4.2.1.67, RHEA:12949]"}
{"concept_id": "C1323993", "aliases": ["D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)", "D-glutamate hydro-lyase (cyclizing)"], "types": ["T044"], "canonical_name": "D-glutamate cyclase activity", "definition": "Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H(2)O. [EC:4.2.1.48, RHEA:22360]"}
{"concept_id": "C1323994", "aliases": ["(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)", "(2R,3S)-2,3-dimethylmalate hydro-lyase activity"], "types": ["T044"], "canonical_name": "dimethylmaleate hydratase activity", "definition": "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H(2)O. [EC:4.2.1.85, RHEA:20253]"}
{"concept_id": "C1323995", "aliases": ["D-gluconate hydro-lyase activity", "D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)", "D-gluconate dehydratase activity"], "types": ["T044"], "canonical_name": "gluconate dehydratase activity", "definition": "Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. [EC:4.2.1.39, RHEA:21612]"}
{"concept_id": "C1323997", "aliases": ["indole-3-acetaldoxime hydro-lyase activity", "indoleacetaldoxime hydro-lyase activity", "3-indoleacetaldoxime hydro-lyase activity", "indole-3-acetaldehyde-oxime hydro-lyase activity", "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity"], "types": ["T044"], "canonical_name": "indoleacetaldoxime dehydratase activity", "definition": "Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H(2)O. [RHEA:23156]"}
{"concept_id": "C1323998", "aliases": ["3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity", "beta-isohexenylglutaconyl-CoA-hydratase activity", "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity", "isohexenylglutaconyl coenzyme A hydratase activity"], "types": ["T044"], "canonical_name": "isohexenylglutaconyl-CoA hydratase activity", "definition": "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H(2)O. [EC:4.2.1.57, RHEA:24144]"}
{"concept_id": "C1323999", "aliases": ["citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)", "citramalyl-CoA hydro-lyase activity", "itaconyl coenzyme A hydratase activity"], "types": ["T044"], "canonical_name": "itaconyl-CoA hydratase activity", "definition": "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O. [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN]"}
{"concept_id": "C1324000", "aliases": ["kievitone-hydrate hydro-lyase (kievitone-forming)", "KHase activity", "kievitone-hydrate hydro-lyase activity"], "types": ["T044"], "canonical_name": "kievitone hydratase activity", "definition": "Catalysis of the reaction: kievitone hydrate = H(2)O + H(+) + kievitone. [EC:4.2.1.95, RHEA:23604]"}
{"concept_id": "C1324001", "aliases": ["L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)", "L-arabonate dehydratase activity", "L-arabinonate hydro-lyase activity", "L-arabonate dehydrase activity"], "types": ["T044"], "canonical_name": "L-arabinonate dehydratase activity", "definition": "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O. [EC:4.2.1.25, RHEA:20968]"}
{"concept_id": "C1324002", "aliases": ["L-fuconate hydratase activity", "L-fuconate hydro-lyase activity", "L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)"], "types": ["T044"], "canonical_name": "L-fuconate dehydratase activity", "definition": "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O. [EC:4.2.1.68, RHEA:22772]"}
{"concept_id": "C1324003", "aliases": ["L-rhamnonate hydro-lyase activity", "L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)"], "types": ["T044"], "canonical_name": "L-rhamnonate dehydratase activity", "definition": "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O. [EC:4.2.1.90, RHEA:23080]"}
{"concept_id": "C1324004", "aliases": ["(R)-malate hydro-lyase activity", "(R)-malate hydro-lyase (maleate-forming)", "D-malate hydro-lyase activity", "malease activity"], "types": ["T044"], "canonical_name": "maleate hydratase activity", "definition": "Catalysis of the reaction: (R)-malate = H(2)O + maleate. [EC:4.2.1.31, RHEA:23692]"}
{"concept_id": "C1324005", "aliases": ["3-oxopropanoate hydro-lyase activity", "malonate-semialdehyde dehydratase activity", "acetylenecarboxylate hydratase activity, producing malonate-semialdehyde", "3-oxopropanoate hydro-lyase (propynoate-forming)", "acetylmonocarboxylic acid hydrase activity", "acetylenecarboxylate hydratase activity", "acetylenemonocarboxylate hydrase activity"], "types": ["T044"], "canonical_name": "acetylenecarboxylate hydratase activity, producing 3-oxopropanoate", "definition": "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O. [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN]"}
{"concept_id": "C1324006", "aliases": ["ketoinositol dehydratase activity", "inosose 2,3-dehydratase activity", "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)", "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity"], "types": ["T044"], "canonical_name": "myo-inosose-2 dehydratase activity", "definition": "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O. [EC:4.2.1.44, RHEA:14065]"}
{"concept_id": "C1324007", "aliases": ["octopamine hydrolyase activity", "octopamine hydro-lyase (deaminating)"], "types": ["T044"], "canonical_name": "octopamine dehydratase activity", "definition": "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH(4)(+). [EC:4.2.1.87, RHEA:18173]"}
{"concept_id": "C1324008", "aliases": ["(R)-10-hydroxystearate 10-hydro-lyase activity", "(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)"], "types": ["T044"], "canonical_name": "oleate hydratase activity", "definition": "Catalysis of the reaction: (R)-10-hydroxystearate = H(2)O + oleate. [EC:4.2.1.53, RHEA:21852]"}
{"concept_id": "C1324009", "aliases": ["phaseollidin-hydrate hydro-lyase (phaseollidin-forming)", "phaseollidin-hydrate hydro-lyase activity"], "types": ["T044"], "canonical_name": "phaseollidin hydratase activity", "definition": "Catalysis of the reaction: phaseollidin hydrate = H(2)O + phaseollidin. [EC:4.2.1.97, RHEA:19769]"}
{"concept_id": "C1324010", "aliases": ["propane-1,2-diol hydro-lyase activity", "adenosylcobalamin-dependent diol dehydratase activity", "coenzyme B12-dependent diol dehydrase activity", "propanediol dehydrase activity", "1,2-propanediol dehydratase activity", "dioldehydratase activity", "diol dehydrase activity", "meso-2,3-butanediol dehydrase activity", "DL-1,2-propanediol hydro-lyase activity", "propane-1,2-diol hydro-lyase (propanal-forming)", "diol dehydratase activity"], "types": ["T044"], "canonical_name": "propanediol dehydratase activity", "definition": "Catalysis of the reaction: propane-1,2-diol = H(2)O + propanal. [EC:4.2.1.28, RHEA:14569]"}
{"concept_id": "C1324011", "aliases": ["protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)", "protoaphin dehydratase activity", "protoaphin dehydratase (cyclizing)", "protoaphin-aglucone hydro-lyase (cyclizing)"], "types": ["T044"], "canonical_name": "protoaphin-aglucone dehydratase (cyclizing) activity", "definition": "Catalysis of the reaction: protoaphin aglucone = H(2)O + xanthoaphin. [EC:4.2.1.73, RHEA:23876]"}
{"concept_id": "C1324012", "aliases": ["beta-pyrazolylalaninase activity", "L-serine hydro-lyase (adding pyrazole)"], "types": ["T044"], "canonical_name": "pyrazolylalanine synthase activity", "definition": "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H(2)O. [EC:4.2.1.50, RHEA:24512]"}
{"concept_id": "C1324013", "aliases": ["1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)"], "types": ["T044"], "canonical_name": "synephrine dehydratase activity", "definition": "Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium. [EC:4.2.1.88, RHEA:32203]"}
{"concept_id": "C1324014", "aliases": ["4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)", "trans-feruloyl-CoA hydro-lyase activity"], "types": ["T044"], "canonical_name": "trans-feruloyl-CoA hydratase activity", "definition": "Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA. [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN]"}
{"concept_id": "C1324015", "aliases": ["trans-L-3-hydroxyproline hydro-lyase activity", "trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)"], "types": ["T044"], "canonical_name": "trans-L-3-hydroxyproline dehydratase activity", "definition": "Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+). [EC:4.2.1.77, RHEA:10320]"}
{"concept_id": "C1324016", "aliases": ["UDPglucose 4,6-dehydratase activity", "UDPglucose 4,6-hydro-lyase activity", "UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)", "UDP-D-glucose oxidoreductase activity", "UDP-D-glucose-4,6-hydrolyase activity", "UDP-glucose 4,6-hydro-lyase activity"], "types": ["T044"], "canonical_name": "UDP-glucose 4,6-dehydratase activity", "definition": "Catalysis of the reaction: UDP-D-glucose = H(2)O + UDP-4-dehydro-6-deoxy-D-glucose. [EC:4.2.1.76, RHEA:21500]"}
{"concept_id": "C1324017", "aliases": ["D-xylo-aldonate dehydratase activity", "D-xylonate dehydratase activity", "D-xylonate hydro-lyase activity", "D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)"], "types": ["T044"], "canonical_name": "xylonate dehydratase activity", "definition": "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O. [EC:4.2.1.82, RHEA:19157]"}
{"concept_id": "C1324018", "aliases": ["(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)", "EaCoMT activity", "(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)", "epoxyalkane:2-mercaptoethanesulfonate transferase activity", "epoxyalkane:CoM transferase activity", "epoxypropane:coenzyme M transferase activity", "coenzyme M-epoxyalkane ligase activity", "epoxyalkyl:CoM transferase activity", "epoxyalkane:coenzyme M transferase activity", "2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)", "epoxypropyl:CoM transferase activity"], "types": ["T044"], "canonical_name": "2-hydroxypropyl-CoM lyase activity", "definition": "Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane. [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN]"}
{"concept_id": "C1324019", "aliases": ["carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)", "carboxymethyloxysuccinate glycolate-lyase activity"], "types": ["T044"], "canonical_name": "carboxymethyloxysuccinate lyase activity", "definition": "Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate. [EC:4.2.99.12, RHEA:12336]"}
{"concept_id": "C1324020", "aliases": ["cysteine sulfoxide lyase activity", "L-cysteine sulfoxide lyase activity", "alliin alkyl-sulfenate-lyase activity", "alkylcysteine sulfoxide lyase activity", "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)", "S-alkylcysteine sulfoxide lyase activity", "cysteine sulphoxide lyase activity", "alliinase activity"], "types": ["T044"], "canonical_name": "alliin lyase activity", "definition": "Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate. [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN]"}
{"concept_id": "C1324021", "aliases": ["L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)", "L-cysteine hydrogen-sulfide-lyase (adding sulfite)", "cysteine (sulfite) lyase activity"], "types": ["T044"], "canonical_name": "cysteine lyase activity", "definition": "Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide. [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN]"}
{"concept_id": "C1324022", "aliases": ["L-cysteine-S-conjugate thiol-lyase (deaminating) activity", "cysteine-S-conjugate b-lyase activity", "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)", "cysteine conjugate beta-lyase activity", "glutamine transaminase K/cysteine conjugate beta-lyase activity"], "types": ["T044"], "canonical_name": "cysteine-S-conjugate beta-lyase activity", "definition": "Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate. [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN]"}
{"concept_id": "C1324023", "aliases": ["S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity", "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)", "desulfhydrase activity"], "types": ["T044"], "canonical_name": "dimethylpropiothetin dethiomethylase activity", "definition": "Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+). [EC:4.4.1.3, RHEA:19965]"}
{"concept_id": "C1324024", "aliases": ["homocysteine desulfurase activity", "L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)", "L-homocysteine hydrogen-sulfide-lyase (deaminating)"], "types": ["T044"], "canonical_name": "homocysteine desulfhydrase activity", "definition": "Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate. [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN]"}
{"concept_id": "C1324025", "aliases": ["beta-cyano-L-alanine synthase activity", "L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)", "beta-cyanoalanine synthase activity", "beta-cyanoalanine synthetase activity", "L-cysteine hydrogen-sulfide-lyase (adding HCN)"], "types": ["T044"], "canonical_name": "L-3-cyanoalanine synthase activity", "definition": "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine. [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN]"}
{"concept_id": "C1324026", "aliases": ["alkyl cysteine lyase activity", "S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity", "S-alkyl-L-cysteinase activity", "alkylcysteine lyase activity", "S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)", "S-alkyl-L-cysteine lyase activity", "S-alkyl-L-cysteine sulfoxide lyase activity", "S-alkylcysteinase activity"], "types": ["T044"], "canonical_name": "S-alkylcysteine lyase activity", "definition": "Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate. [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN]"}
{"concept_id": "C1324027", "aliases": ["sulphoacetaldehyde lyase activity"], "types": ["T044"], "canonical_name": "sulfoacetaldehyde lyase activity", "definition": "Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite. [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN]"}
{"concept_id": "C1324029", "aliases": ["cytidyl cyclase activity", "CTP diphosphate-lyase (cyclizing)", "3'5'-cyclic-CMP synthase activity", "CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)", "cytidylyl cyclase activity", "3',5'-cyclic-CMP synthase activity"], "types": ["T044"], "canonical_name": "cytidylate cyclase activity", "definition": "Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+). [EC:4.6.1.6, RHEA:14737]"}
{"concept_id": "C1324030", "aliases": ["variant-surface-glycoprotein phospholipase C activity", "GPI-PLC activity", "GPI-specific phospholipase C activity", "(glycosyl)phosphatidylinositol-specific phospholipase C activity", "glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity", "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity", "VSG-lipase activity", "glycosylphosphatidylinositol-specific phospholipase C activity"], "types": ["T044"], "canonical_name": "glycosylphosphatidylinositol diacylglycerol-lyase activity", "definition": "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate. [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN]"}
{"concept_id": "C1324032", "aliases": ["acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)"], "types": ["T044"], "canonical_name": "glycine reductase activity", "definition": "Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin. [EC:1.21.4.2, RHEA:12232]"}
{"concept_id": "C1324033", "aliases": ["4-hydroxyphenylacetate,FADH:oxygen oxidoreductase (3-hydroxylating) activity", "p-hydroxyphenylacetate hydroxylase (FAD) activity", "p-hydroxyphenylacetate 3-hydroxylase (FAD) activity"], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetate 3-monooxygenase activity", "definition": "Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(+) + H(2)O. [RHEA:30595]"}
{"concept_id": "C1324034", "aliases": ["lysine N(6)-hydroxylase activity", "L-lysine 6-monooxygenase (NADPH) activity", "L-lysine 6-monooxygenase activity", "lysine N6-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-lysine + NADPH + O(2) = N(6)-hydroxy-L-lysine + H(2)O + NADP(+). [EC:1.14.13.59, RHEA:23228]", "canonical_name": "L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)"}
{"concept_id": "C1324035", "aliases": [], "types": ["T044"], "canonical_name": "ecdysteroid 2-hydroxylase activity", "definition": "Catalysis of the hydroxylation of an ecdysteroid at carbon position 2. [PMID:12177427]"}
{"concept_id": "C1324036", "aliases": [], "types": ["T044"], "canonical_name": "ecdysteroid 22-hydroxylase activity", "definition": "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22. [PMID:12177427]"}
{"concept_id": "C1324037", "aliases": [], "types": ["T044"], "canonical_name": "steroid 22-alpha hydroxylase activity", "definition": "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O. [GOC:tb]"}
{"concept_id": "C1324038", "aliases": ["testosterone 6b-hydroxylase activity"], "types": ["T044"], "canonical_name": "testosterone 6-beta-hydroxylase activity", "definition": "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. [GOC:ai, PMID:11726664]"}
{"concept_id": "C1324039", "aliases": ["(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "D-lactate dehydrogenase (cytochrome c-553) activity", "definition": "Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate. [RHEA:16465]"}
{"concept_id": "C1324040", "aliases": ["D-mannitol:ferricytochrome-c 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "mannitol dehydrogenase (cytochrome) activity", "definition": "Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+. [RHEA:17597]"}
{"concept_id": "C1324041", "aliases": ["vitamin K 2,3-epoxide reductase activity"], "types": ["T044"], "canonical_name": "vitamin-K-epoxide reductase (warfarin-insensitive) activity", "definition": "Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. [RHEA:21560]"}
{"concept_id": "C1324042", "aliases": ["phylloquinone epoxide reductase activity"], "types": ["T044"], "canonical_name": "vitamin-K-epoxide reductase (warfarin-sensitive) activity", "definition": "Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues. [RHEA:57744]"}
{"concept_id": "C1324043", "aliases": ["bicyclic monoterpenol dehydrogenase activity", "(+)-borneol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(+)-borneol dehydrogenase activity", "definition": "Catalysis of the reaction: (+)-borneol + NAD(+) = (1R, 4R)-camphor + H(+) + NADH. [EC:1.1.1.198, RHEA:17329]"}
{"concept_id": "C1324044", "aliases": ["(+)-neomenthol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(+)-neomenthol dehydrogenase activity", "definition": "Catalysis of the reaction: (+)-neomenthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH. [EC:1.1.1.208, RHEA:23812]"}
{"concept_id": "C1324045", "aliases": ["(+)-cis-sabinol:NAD+ oxidoreductase activity", "(+)-cis-sabinol dehydrogenase activity"], "types": ["T044"], "canonical_name": "(+)-sabinol dehydrogenase activity", "definition": "Catalysis of the reaction: (+)-cis-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH. [EC:1.1.1.228, RHEA:18329]"}
{"concept_id": "C1324046", "aliases": ["(-)-borneol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(-)-borneol dehydrogenase activity", "definition": "Catalysis of the reaction: (-)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH. [EC:1.1.1.227, RHEA:22128]"}
{"concept_id": "C1324047", "aliases": ["(-)-menthol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(-)-menthol dehydrogenase activity", "definition": "Catalysis of the reaction: (-)-menthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH. [EC:1.1.1.207, RHEA:13917]"}
{"concept_id": "C1324049", "aliases": ["(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity", "(R)-sulfolactate:NAD(P)+ oxidoreductase activity", "L-sulfolactate dehydrogenase activity", "(R)-sulfolactate:NAD(P)(+) oxidoreductase activity"], "types": ["T044"], "canonical_name": "(R)-2-hydroxyacid dehydrogenase activity", "definition": "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+. [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN]"}
{"concept_id": "C1324050", "aliases": ["3-oxo ester (R)-reductase activity", "ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity", "(R)-3-hydroxyacid ester dehydrogenase activity"], "types": ["T044"], "canonical_name": "(R)-3-hydroxyacid-ester dehydrogenase activity", "definition": "Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH. [EC:1.1.1.279, RHEA:24352]"}
{"concept_id": "C1324051", "aliases": [], "types": ["T044"], "canonical_name": "(R)-4-hydroxyphenyllactate dehydrogenase (NADPH) activity", "definition": "Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate. [RHEA:52692]"}
{"concept_id": "C1324053", "aliases": ["3-oxo ester (S)-reductase activity", "ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity", "(S)-3-hydroxyacid ester dehydrogenase activity"], "types": ["T044"], "canonical_name": "(S)-3-hydroxyacid-ester dehydrogenase activity", "definition": "Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH. [EC:1.1.1.280, RHEA:18269]"}
{"concept_id": "C1324054", "aliases": ["(S)-carnitine:NAD+ oxidoreductase activity", "D-carnitine dehydrogenase activity"], "types": ["T044"], "canonical_name": "(S)-carnitine 3-dehydrogenase activity", "definition": "Catalysis of the reaction: (S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH. [EC:1.1.1.254, RHEA:11556]"}
{"concept_id": "C1324055", "aliases": ["L-usnic acid dehydrogenase activity", "reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)"], "types": ["T044"], "canonical_name": "(S)-usnate reductase activity", "definition": "Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH. [EC:1.1.1.199, RHEA:21876]"}
{"concept_id": "C1324056", "aliases": ["L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)", "L-butanediol dehydrogenase activity", "L-BDH", "(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(S,S)-butanediol dehydrogenase activity", "definition": "Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD(+) = acetoin + H(+) + NADH. [EC:1.1.1.76, RHEA:12184]"}
{"concept_id": "C1324057", "aliases": ["1,3-propanediol:NAD+ oxidoreductase activity", "1,3-PD:NAD+ oxidoreductase activity", "3-hydroxypropionaldehyde reductase activity", "propane-1,3-diol:NAD+ 1-oxidoreductase activity", "1,3-propanediol oxidoreductase activity"], "types": ["T044"], "canonical_name": "1,3-propanediol dehydrogenase activity", "definition": "Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+. [EC:1.1.1.202, MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324058", "aliases": ["1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity", "AF reductase activity"], "types": ["T044"], "canonical_name": "1,5-anhydro-D-fructose reductase activity", "definition": "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH. [EC:1.1.1.263, RHEA:20665]"}
{"concept_id": "C1324059", "aliases": ["15-hydroxyeicosatetraenoate dehydrogenase activity", "(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity"], "types": ["T044"], "canonical_name": "15-hydroxyicosatetraenoate dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate. [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN]"}
{"concept_id": "C1324060", "aliases": ["type II 15-hydroxyprostaglandin dehydrogenase activity", "(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity"], "types": ["T044"], "canonical_name": "15-hydroxyprostaglandin dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH. [EC:1.1.1.197, RHEA:11636]"}
{"concept_id": "C1324061", "aliases": ["15-hydroxyprostaglandin dehydrogenase (NADP)", "dehydrogenase, prostaglandin D2", "dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)", "NADP-linked prostaglandin D2 dehydrogenase activity", "prostaglandin-D 15-dehydrogenase (NADP)", "prostaglandin-D 15-dehydrogenase (NADP(+)) activity", "(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity", "prostaglandin-D 15-dehydrogenase (NADP+) activity", "15-hydroxy PGD2 dehydrogenase activity", "prostaglandin D2 dehydrogenase activity", "NADP-PGD2 dehydrogenase activity"], "types": ["T044"], "canonical_name": "15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate. [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN]"}
{"concept_id": "C1324062", "aliases": ["PG I2 dehydrogenase activity", "prostacyclin dehydrogenase activity", "NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity", "(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity", "NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity"], "types": ["T044"], "canonical_name": "15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: NADP(+) + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H(+) + NADPH. [EC:1.1.1.231, RHEA:21420]"}
{"concept_id": "C1324063", "aliases": ["2,5-diketo-D-gluconate reductase activity", "2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2,5-didehydrogluconate reductase activity", "definition": "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+. [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN]"}
{"concept_id": "C1324064", "aliases": ["2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity", "2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-(R)-hydroxypropyl-CoM dehydrogenase activity", "definition": "Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH. [EC:1.1.1.268, RHEA:13249]"}
{"concept_id": "C1324065", "aliases": ["2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity", "2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-(S)-hydroxypropyl-CoM dehydrogenase activity", "definition": "Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH. [EC:1.1.1.269, RHEA:21052]"}
{"concept_id": "C1324066", "aliases": ["2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-alkyn-1-ol dehydrogenase activity", "definition": "Catalysis of the reaction: 2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH. [EC:1.1.1.165, RHEA:19101]"}
{"concept_id": "C1324067", "aliases": ["2-keto-3-deoxygluconate dehydrogenase activity", "2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity", "2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity", "2-keto-3-deoxygluconate 5-dehydrogenase activity", "2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity", "definition": "Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate. [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN]"}
{"concept_id": "C1324068", "aliases": ["2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity", "2-keto-3-deoxy-D-gluconate dehydrogenase activity"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity", "definition": "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH. [EC:1.1.1.126, RHEA:15109]"}
{"concept_id": "C1324069", "aliases": ["(R)-pantolactone:NADP+ oxidoreductase (A-specific)", "2-dehydropantoyl-lactone reductase (A-specific) activity"], "types": ["T044"], "canonical_name": "2-dehydropantolactone reductase (A-specific) activity", "definition": "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+. [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN]"}
{"concept_id": "C1324070", "aliases": ["alpha-ketoadipate reductase activity", "2-hydroxyadipate:NAD+ 2-oxidoreductase activity", "2-ketoadipate reductase activity"], "types": ["T044"], "canonical_name": "2-oxoadipate reductase activity", "definition": "Catalysis of the reaction: 2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH. [EC:1.1.1.172, RHEA:14793]"}
{"concept_id": "C1324071", "aliases": ["etiocholanolone 3alpha-dehydrogenase activity", "3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity", "etiocholanolone 3-alpha-dehydrogenase activity", "3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity", "3alpha-hydroxy-5beta-steroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity", "definition": "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione. [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN]"}
{"concept_id": "C1324072", "aliases": ["3alpha-hydroxycholanate dehydrogenase activity", "alpha-hydroxy-cholanate dehydrogenase activity", "3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "3-alpha-hydroxycholanate dehydrogenase activity", "definition": "Catalysis of the reaction: lithocholate + NAD(+) = 3-oxo-5beta-cholanate + H(+) + NADH. [EC:1.1.1.52, RHEA:19585]"}
{"concept_id": "C1324073", "aliases": ["3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity", "3alpha-hydroxyglycyrrhetinate dehydrogenase activity"], "types": ["T044"], "canonical_name": "3-alpha-hydroxyglycyrrhetinate dehydrogenase activity", "definition": "Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH. [EC:1.1.1.230, RHEA:20816]"}
{"concept_id": "C1324074", "aliases": ["3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity", "2-hydroxy-3-carboxyadipate dehydrogenase activity", "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)", "homoisocitric dehydrogenase activity", "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity", "3-carboxy-2-hydroxyadipate dehydrogenase activity", "3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)", "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "homoisocitrate dehydrogenase activity", "definition": "Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate. [EC:1.1.1.155, EC:1.1.1.87, MetaCyc:1.1.1.87-RXN]"}
{"concept_id": "C1324075", "aliases": ["3-keto-L-gulonate dehydrogenase activity", "3-ketogulonate dehydrogenase activity", "3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity", "2,3-diketo-L-gulonate reductase activity"], "types": ["T044"], "canonical_name": "3-dehydro-L-gulonate 2-dehydrogenase activity", "definition": "Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+. [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324076", "aliases": ["D-3-dehydrosphinganine reductase activity", "3-ketosphinganine reductase activity", "3-oxosphinganine:NADPH oxidoreductase activity", "D-3-oxosphinganine:B-NADPH oxidoreductase activity", "3-oxosphinganine reductase activity", "D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity", "DSR activity", "D-3-oxosphinganine reductase activity"], "types": ["T044"], "canonical_name": "3-dehydrosphinganine reductase activity", "definition": "Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH. [EC:1.1.1.102, RHEA:22640]"}
{"concept_id": "C1324077", "aliases": ["2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity", "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity", "2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity", "2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity"], "types": ["T044"], "canonical_name": "3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA. [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN]"}
{"concept_id": "C1324078", "aliases": ["3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity", "m-hydroxybenzylalcohol dehydrogenase activity", "m-hydroxybenzyl alcohol (NADP) dehydrogenase activity", "m-hydroxybenzyl alcohol dehydrogenase activity"], "types": ["T044"], "canonical_name": "3-hydroxybenzyl-alcohol dehydrogenase activity", "definition": "Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH. [EC:1.1.1.97, RHEA:22340]"}
{"concept_id": "C1324081", "aliases": [], "types": ["T044"], "canonical_name": "3-ketoglucose-reductase activity", "definition": "Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose. [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN]"}
{"concept_id": "C1324082", "aliases": ["3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity", "3-oxoacyl-acyl-carrier-protein reductase (NADH)", "(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity", "3-oxoacyl-ACP reductase (NADH) activity", "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity"], "types": ["T044"], "canonical_name": "3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity", "definition": "Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]. [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN]"}
{"concept_id": "C1324083", "aliases": ["gamma-hydroxybutyrate dehydrogenase activity", "4-hydroxybutanoate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "4-hydroxybutyrate dehydrogenase activity", "definition": "Catalysis of the reaction: 4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde. [EC:1.1.1.61, RHEA:23948]"}
{"concept_id": "C1324084", "aliases": ["trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity", "trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity"], "types": ["T044"], "canonical_name": "4-hydroxycyclohexanecarboxylate dehydrogenase activity", "definition": "Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD(+) = 4-oxocyclohexanecarboxylate + H(+) + NADH. [EC:1.1.1.226, RHEA:17429]"}
{"concept_id": "C1324085", "aliases": ["4-(phosphohydroxy)-L-threonine dehydrogenase activity", "L-threonine 4-phosphate dehydrogenase activity", "PdxA", "NAD+-dependent threonine 4-phosphate dehydrogenase activity", "4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity", "NAD(+)-dependent threonine 4-phosphate dehydrogenase activity"], "types": ["T044"], "canonical_name": "4-hydroxythreonine-4-phosphate dehydrogenase activity", "definition": "Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+. [EC:1.1.1.262, RHEA:32275]"}
{"concept_id": "C1324086", "aliases": ["6-pyruvoyltetrahydropterin reductase activity", "6-pyruvoyl-tetrahydropterin 2'-reductase activity", "6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity", "6PPH4(2'-oxo) reductase activity", "6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity", "pyruvoyl-tetrahydropterin reductase activity"], "types": ["T044"], "canonical_name": "6-pyruvoyltetrahydropterin 2'-reductase activity", "definition": "Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin. [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN]"}
{"concept_id": "C1324087", "aliases": ["8-ketodeoxycoformycin reductase activity", "coformycin:NADP+ 8-oxidoreductase activity"], "types": ["T044"], "canonical_name": "8-oxocoformycin reductase activity", "definition": "Catalysis of the reaction: coformycin + NADP(+) = 8-oxocoformycin + 2 H(+) + NADPH. [EC:1.1.1.235, RHEA:23168]"}
{"concept_id": "C1324088", "aliases": ["alcohol:NAD(P)+ oxidoreductase activity", "aldehyde reductase (NADPH/NADH)"], "types": ["T044"], "canonical_name": "alcohol dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+. [EC:1.1.1.71]"}
{"concept_id": "C1324089", "aliases": ["dehydrogenase, D-aldohexose", "aldose dehydrogenase activity", "D-aldose:NAD+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "aldose 1-dehydrogenase activity", "definition": "Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH. [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324090", "aliases": ["aldose-6-phosphate reductase activity", "A6PR", "NADP-dependent aldose 6-phosphate reductase activity", "aldose 6-phosphate reductase activity", "NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity", "alditol 6-phosphate:NADP 1-oxidoreductase activity", "D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity", "aldose-6-P reductase activity"], "types": ["T044"], "canonical_name": "aldose-6-phosphate reductase (NADPH) activity", "definition": "Catalysis of the reaction: D-glucitol 6-phosphate + NADP(+) = D-glucose 6-phosphate + H(+) + NADPH. [EC:1.1.1.200, RHEA:20037]"}
{"concept_id": "C1324091", "aliases": ["allyl-alcohol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "allyl-alcohol dehydrogenase activity", "definition": "Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH. [EC:1.1.1.54, RHEA:12168]"}
{"concept_id": "C1324092", "aliases": ["D-apiitol reductase activity", "D-apiitol:NAD+ 1-oxidoreductase activity", "D-apiose reductase activity"], "types": ["T044"], "canonical_name": "apiose 1-reductase activity", "definition": "Catalysis of the reaction: D-apiitol + NAD(+) = D-apiose + H(+) + NADH. [EC:1.1.1.114, RHEA:15301]"}
{"concept_id": "C1324093", "aliases": ["aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)", "NADPH-linked benzaldehyde reductase activity", "aryl-alcohol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "aryl-alcohol dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH. [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN]"}
{"concept_id": "C1324094", "aliases": ["benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity", "benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity"], "types": ["T044"], "canonical_name": "benzyl-2-methyl-hydroxybutyrate dehydrogenase activity", "definition": "Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH. [EC:1.1.1.217, RHEA:16405]"}
{"concept_id": "C1324095", "aliases": ["carnitine:NAD+ 3-oxidoreductase activity"], "types": ["T044"], "canonical_name": "carnitine 3-dehydrogenase activity", "definition": "Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH. [EC:1.1.1.108, RHEA:19265]"}
{"concept_id": "C1324096", "aliases": ["chlordecone-alcohol:NADP+ 2-oxidoreductase activity", "CDR activity"], "types": ["T044"], "canonical_name": "chlordecone reductase activity", "definition": "Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH. [EC:1.1.1.225, RHEA:14401]"}
{"concept_id": "C1324097", "aliases": ["cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity", "cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity", "3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity"], "types": ["T044"], "canonical_name": "cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity", "definition": "Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one. [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN]"}
{"concept_id": "C1324098", "aliases": ["5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity", "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity", "cholestanetetrol 26-dehydrogenase activity", "TEHC-NAD oxidoreductase activity"], "types": ["T044"], "canonical_name": "cholestanetetraol 26-dehydrogenase activity", "definition": "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH. [RHEA:34631]"}
{"concept_id": "C1324099", "aliases": ["codeine:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "codeinone reductase (NADPH) activity", "definition": "Catalysis of the reaction: codeine + NADP(+) = codeinone + H(+) + NADPH. [EC:1.1.1.247, RHEA:19209]"}
{"concept_id": "C1324100", "aliases": ["coniferyl-alcohol dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH. [EC:1.1.1.194, MetaCyc:RXN-1107]", "canonical_name": "coniferyl-alcohol:NADP+ oxidoreductase activity"}
{"concept_id": "C1324101", "aliases": ["trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "cyclohexane-1,2-diol dehydrogenase activity", "definition": "Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH. [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324102", "aliases": ["D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)", "D-arabinitol 2-dehydrogenase (ribulose-forming) activity"], "types": ["T044"], "canonical_name": "D-arabinitol 2-dehydrogenase activity", "definition": "Catalysis of the reaction: D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH. [EC:1.1.1.250, RHEA:17389]"}
{"concept_id": "C1324103", "aliases": [], "types": ["T044"], "canonical_name": "D-arabinitol 4-dehydrogenase activity", "definition": "Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH. [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324105", "aliases": [], "types": ["T044"], "canonical_name": "D-iditol 2-dehydrogenase activity", "definition": "Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH. [EC:1.1.1.15, MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324106", "aliases": ["5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity", "1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "D-pinitol dehydrogenase activity", "definition": "Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH. [EC:1.1.1.142, RHEA:20437]"}
{"concept_id": "C1324107", "aliases": ["dehydrogenase, L-fucose", "D-threo-aldose:NAD+ 1-oxidoreductase activity", "(2S,3R)-aldose dehydrogenase activity", "L-fucose (D-arabinose) dehydrogenase activity", "L-fucose dehydrogenase activity"], "types": ["T044"], "canonical_name": "D-threo-aldose 1-dehydrogenase activity", "definition": "Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH. [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324108", "aliases": ["D-xylose-NADP dehydrogenase activity", "D-xylose:NADP+ 1-oxidoreductase activity", "D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity", "D-xylose:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "D-xylose 1-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH. [EC:1.1.1.179, RHEA:22000]"}
{"concept_id": "C1324110", "aliases": ["diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity"], "types": ["T044"], "canonical_name": "diethyl 2-methyl-3-oxosuccinate reductase activity", "definition": "Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH. [EC:1.1.1.229, RHEA:21008]"}
{"concept_id": "C1324111", "aliases": ["bunolol reductase activity", "(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "dihydrobunolol dehydrogenase activity", "definition": "Catalysis of the reaction: dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH. [EC:1.1.1.160, RHEA:15925]"}
{"concept_id": "C1324112", "aliases": ["KAR", "diiodophenylpyruvate reductase activity", "aromatic alpha-keto acid", "(2R)-hydroxycarboxylate-viologen-oxidoreductase activity", "2-oxo acid reductase activity", "(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity", "HVOR", "2-oxoacid reductase activity", "3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH. [EC:1.1.1.96, RHEA:20293]", "canonical_name": "2-oxo-acid reductase activity"}
{"concept_id": "C1324113", "aliases": ["(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)", "beta,beta-dimethylmalate dehydrogenase activity"], "types": ["T044"], "canonical_name": "dimethylmalate dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO(2) + NADH. [EC:1.1.1.84, RHEA:13321]"}
{"concept_id": "C1324114", "aliases": ["dTDP-4-keto-6-deoxyglucose reductase activity", "dTDP-D-fucose:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "dTDP-4-dehydro-6-deoxyglucose reductase activity", "definition": "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH. [EC:1.1.1.266, RHEA:36583]"}
{"concept_id": "C1324115", "aliases": ["TDP-6-deoxy-L-talose dehydrogenase activity", "thymidine diphospho-6-deoxy-L-talose dehydrogenase activity", "dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity", "dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)"], "types": ["T044"], "canonical_name": "dTDP-6-deoxy-L-talose 4-dehydrogenase activity", "definition": "Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH. [EC:1.1.1.134, RHEA:23648]"}
{"concept_id": "C1324116", "aliases": ["erythritol:NADP+ oxidoreductase activity", "D-erythrulose reductase activity"], "types": ["T044"], "canonical_name": "erythrulose reductase activity", "definition": "Catalysis of the reaction: D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH. [EC:1.1.1.162, RHEA:18005]"}
{"concept_id": "C1324117", "aliases": ["farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity", "NADP-farnesol dehydrogenase activity", "2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "farnesol dehydrogenase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH. [EC:1.1.1.216, RHEA:14697]"}
{"concept_id": "C1324118", "aliases": ["(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity", "flavonone 4-reductase activity"], "types": ["T044"], "canonical_name": "flavanone 4-reductase activity", "definition": "Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH. [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN]"}
{"concept_id": "C1324119", "aliases": ["5-ketofructose reductase (NADP+) activity", "D-fructose:NADP+ 5-oxidoreductase activity", "5-ketofructose reductase (NADP)", "5-ketofructose reductase (NADP(+)) activity", "D-(-)fructose:(NADP+) 5-oxidoreductase activity", "5-keto-D-fructose reductase (NADP+)", "fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH. [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN]", "canonical_name": "fructose 5-dehydrogenase (NADP+) activity"}
{"concept_id": "C1324120", "aliases": [], "types": ["T044"], "canonical_name": "galactitol 2-dehydrogenase activity", "definition": "Catalysis of the reaction: galactitol + NAD(+) = D-tagatose + H(+) + NADH. [EC:1.1.1.16, RHEA:20685]"}
{"concept_id": "C1324121", "aliases": ["D-galactose dehydrogenase (NADP+)", "D-galactose:NADP+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "galactose 1-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH. [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN]"}
{"concept_id": "C1324122", "aliases": ["GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity", "guanosine diphospho-6-deoxy-D-talose dehydrogenase activity"], "types": ["T044"], "canonical_name": "GDP-6-deoxy-D-talose 4-dehydrogenase activity", "definition": "Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+. [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324123", "aliases": ["GDP-fucose synthetase activity", "GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity", "GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)"], "types": ["T044"], "canonical_name": "GDP-L-fucose synthase activity", "definition": "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+. [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]"}
{"concept_id": "C1324124", "aliases": ["GDP-D-mannose:NAD+ 6-oxidoreductase activity", "GDPmannose 6-dehydrogenase activity", "GDP mannose dehydrogenase activity", "guanosine diphosphomannose dehydrogenase activity", "guanosine diphospho-D-mannose dehydrogenase activity"], "types": ["T044"], "canonical_name": "GDP-mannose 6-dehydrogenase activity", "definition": "Catalysis of the reaction: GDP-alpha-D-mannose + H(2)O + 2 NAD(+) = GDP-D-mannuronate + 3 H(+) + 2 NADH. [EC:1.1.1.132, RHEA:21728]"}
{"concept_id": "C1324125", "aliases": ["geraniol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "geraniol dehydrogenase activity", "definition": "Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH. [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324127", "aliases": ["D-glucose:NAD+ 1-oxidoreductase activity", "D-glucose:NAD oxidoreductase activity", "D-aldohexose dehydrogenase activity"], "types": ["T044"], "canonical_name": "glucose 1-dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH. [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN]"}
{"concept_id": "C1324128", "aliases": ["NADP-linked aldohexose dehydrogenase activity", "NADP-dependent glucose dehydrogenase activity", "D-glucose:NADP+ 1-oxidoreductase activity", "nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity"], "types": ["T044"], "canonical_name": "glucose 1-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH. [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN]"}
{"concept_id": "C1324129", "aliases": [], "types": ["T044"], "canonical_name": "glucuronolactone reductase activity", "definition": "Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH. [EC:1.1.1.20, RHEA:18925]"}
{"concept_id": "C1324130", "aliases": ["dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "glycerol:NADP+ 2-oxidoreductase (glycerone-forming)", "dihydroxyacetone reductase (NADPH)", "dihydroxyacetone reductase activity", "DHA oxidoreductase activity"], "types": ["T044"], "canonical_name": "glycerol 2-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: glycerol + NADP(+) = glycerone + H(+) + NADPH. [EC:1.1.1.156, RHEA:12753]"}
{"concept_id": "C1324131", "aliases": ["glycerol dehydrogenase (NADP+) activity", "glycerol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "glycerol dehydrogenase [NADP+] activity", "definition": "Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH. [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN]"}
{"concept_id": "C1324132", "aliases": ["sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "glycerol-1-phosphate dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate. [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN]"}
{"concept_id": "C1324134", "aliases": ["glycerol-3-phosphate dehydrogenase (NAD(P)+) activity", "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity", "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity", "glycerol-3-phosphate dehydrogenase [NADP+] activity", "sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "glycerol-3-phosphate dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+. [EC:1.1.1.94]"}
{"concept_id": "C1324135", "aliases": ["glyoxylic acid reductase activity", "NADH-dependent glyoxylate reductase activity"], "types": ["T044"], "canonical_name": "glycolate reductase activity"}
{"concept_id": "C1324136", "aliases": ["hexadecanol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "hexadecanol dehydrogenase activity", "definition": "Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH. [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324138", "aliases": ["dihydroxycyclohexanecarboxylate dehydrogenase activity", "(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity", "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydroxycyclohexanecarboxylate dehydrogenase activity", "definition": "Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH. [EC:1.1.1.166, RHEA:10516]"}
{"concept_id": "C1324139", "aliases": ["hydroxymalonate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydroxymalonate dehydrogenase activity", "definition": "Catalysis of the reaction: hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate. [EC:1.1.1.167, RHEA:11284]"}
{"concept_id": "C1324140", "aliases": ["HPRP", "hydroxyphenylpyruvate reductase activity", "4-hydroxyphenyllactate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydroxyphenylpyruvate reductase activity", "definition": "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH. [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN, RHEA:10780]"}
{"concept_id": "C1324141", "aliases": ["indan-1-ol:NAD(P)+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "indanol dehydrogenase activity", "definition": "Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324142", "aliases": ["indoleacetaldehyde reductase activity", "(indol-3-yl)ethanol:NAD+ oxidoreductase activity", "indole-3-ethanol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "indole-3-acetaldehyde reductase (NADH) activity", "definition": "Catalysis of the reaction: indole-3-ethanol + NAD(+) = (indol-3-yl)acetaldehyde + H(+) + NADH. [EC:1.1.1.190, RHEA:14873]"}
{"concept_id": "C1324143", "aliases": ["(indol-3-yl)ethanol:NADP+ oxidoreductase activity", "indole-3-ethanol:NADP+ oxidoreductase activity", "indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity"], "types": ["T044"], "canonical_name": "indole-3-acetaldehyde reductase (NADPH) activity", "definition": "Catalysis of the reaction: indole-3-ethanol + NADP(+) = (indol-3-yl)acetaldehyde + H(+) + NADPH. [EC:1.1.1.191, RHEA:17037]"}
{"concept_id": "C1324144", "aliases": ["indolelactate:NAD+ oxidoreductase activity", "(indol-3-yl)lactate:NAD+ oxidoreductase activity", "indole-3-lactate dehydrogenase activity"], "types": ["T044"], "canonical_name": "indolelactate dehydrogenase (NADH) activity", "definition": "Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD(+) = 3-(indol-3-yl)pyruvate + H(+) + NADH. [RHEA:20133]"}
{"concept_id": "C1324145", "aliases": ["inositol:NAD 2-dehydrogenase activity", "myo-inositol 2-dehydrogenase activity"], "types": ["T044"], "canonical_name": "inositol 2-dehydrogenase activity", "definition": "Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH. [EC:1.1.1.18, RHEA:16949]"}
{"concept_id": "C1324146", "aliases": ["propan-2-ol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "isopropanol dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: NADP(+) + propan-2-ol = acetone + H(+) + NADPH. [EC:1.1.1.80, RHEA:21792]"}
{"concept_id": "C1324147", "aliases": ["L-arabinitol 2-dehydrogenase (ribulose forming) activity"], "types": ["T044"], "canonical_name": "L-arabinitol 2-dehydrogenase activity", "definition": "Catalysis of the reaction: L-arabinitol + NAD(+) = L-ribulose + H(+) + NADH. [EC:1.1.1.13, RHEA:21356]"}
{"concept_id": "C1324148", "aliases": [], "types": ["T044"], "canonical_name": "L-arabinitol 4-dehydrogenase activity", "definition": "Catalysis of the reaction: L-arabinitol + NAD(+) = L-xylulose + H(+) + NADH. [EC:1.1.1.12, RHEA:16381]"}
{"concept_id": "C1324149", "aliases": ["L-arabinose 1-dehydrogenase activity", "L-arabinose:NAD+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "L-arabinose 1-dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH. [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324150", "aliases": ["TPN-L-gulonate dehydrogenase activity", "glucuronate dehydrogenase activity", "NADP-L-gulonate dehydrogenase activity", "glucuronate reductase activity", "D-glucuronate dehydrogenase activity"], "types": ["T044"], "canonical_name": "L-glucuronate reductase activity", "definition": "Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH. [EC:1.1.1.19, RHEA:14909]"}
{"concept_id": "C1324151", "aliases": ["glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity", "L-(+)-glycol:NAD(P) oxidoreductase activity", "L-glycol:NAD(P) dehydrogenase activity", "L-glycol:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "L-glycol dehydrogenase activity", "definition": "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+. [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324152", "aliases": ["L-gulonic acid dehydrogenase activity", "L-3-aldonate dehydrogenase activity", "L-beta-hydroxy-acid-NAD-oxidoreductase activity", "L-gulonate:NAD+ 3-oxidoreductase activity", "L-beta-hydroxyacid dehydrogenase activity", "L-3-aldonic dehydrogenase activity", "L-3-hydroxyacid dehydrogenase activity"], "types": ["T044"], "canonical_name": "L-gulonate 3-dehydrogenase activity", "definition": "Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH. [EC:1.1.1.45, RHEA:12889]"}
{"concept_id": "C1324154", "aliases": ["L-idonate:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "L-idonate 5-dehydrogenase activity", "definition": "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+. [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN]"}
{"concept_id": "C1324155", "aliases": ["L-rhamnofuranose:NAD+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "L-rhamnose 1-dehydrogenase activity", "definition": "Catalysis of the reaction: L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + H(+) + NADH. [EC:1.1.1.173, RHEA:12649]"}
{"concept_id": "C1324156", "aliases": ["threonate dehydrogenase activity", "L-threonate:NAD+ 3-oxidoreductase activity", "L-threonic acid dehydrogenase activity"], "types": ["T044"], "canonical_name": "L-threonate 3-dehydrogenase activity", "definition": "Catalysis of the reaction: L-threonate + NAD(+) = 3-dehydro-L-threonate + H(+) + NADH. [EC:1.1.1.129, RHEA:23376]"}
{"concept_id": "C1324157", "aliases": ["L-xylose:NADP+ 1-oxidoreductase activity", "L-xylose dehydrogenase activity", "NADPH-xylose reductase activity"], "types": ["T044"], "canonical_name": "L-xylose 1-dehydrogenase activity", "definition": "Catalysis of the reaction: aldehydo-L-xylose + NADP(+) = L-xylono-1,4-lactone + H(+) + NADPH. [EC:1.1.1.113, RHEA:15789]"}
{"concept_id": "C1324158", "aliases": ["L-xylulose reductase activity"], "types": ["T044"], "canonical_name": "L-xylulose reductase (NADP+) activity", "definition": "Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH. [EC:1.1.1.10, RHEA:17025]"}
{"concept_id": "C1324159", "aliases": ["1,2-propanediol:NADP+ oxidoreductase activity", "propanediol dehydrogenase activity", "lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "NADP-1,2-propanediol dehydrogenase activity", "propane-1,2-diol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "lactaldehyde reductase (NADPH) activity", "definition": "Catalysis of the reaction: NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH. [EC:1.1.1.55, RHEA:15885]"}
{"concept_id": "C1324160", "aliases": ["long-chain alcohol dehydrogenase activity", "fatty alcohol oxidoreductase activity", "long-chain-alcohol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "long-chain-alcohol dehydrogenase activity", "definition": "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH. [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324161", "aliases": ["D-mannitol:NADP+ 2-oxidoreductase activity", "NADP-dependent mannitol dehydrogenase activity"], "types": ["T044"], "canonical_name": "mannitol 2-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH. [EC:1.1.1.138, RHEA:16765]"}
{"concept_id": "C1324162", "aliases": ["D-mannitol dehydrogenase activity", "D-mannitol:NAD+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "mannitol 2-dehydrogenase activity", "definition": "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH. [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324163", "aliases": ["mannose-6-phosphate reductase activity", "NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity", "NADPH-dependent mannose 6-phosphate reductase activity", "D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity", "6-phosphomannose reductase activity", "NADPH-dependent M6P reductase activity", "NADPH-mannose-6-P reductase activity"], "types": ["T044"], "canonical_name": "mannose-6-phosphate 6-reductase activity", "definition": "Catalysis of the reaction: D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + 3 H(+) + NADPH. [EC:1.1.1.224, RHEA:14925]"}
{"concept_id": "C1324164", "aliases": ["D-mannonate:NAD(P)+ 6-oxidoreductase activity", "D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))", "mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity", "mannonate dehydrogenase activity", "mannonate dehydrogenase (NAD(P)+)"], "types": ["T044"], "canonical_name": "mannuronate reductase activity", "definition": "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+. [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN]"}
{"concept_id": "C1324165", "aliases": ["methanol dehydrogenase activity"], "types": ["T044"], "canonical_name": "methanol dehydrogenase activity", "definition": "Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH. [EC:1.1.1.244, RHEA:19401]"}
{"concept_id": "C1324166", "aliases": ["morphine:NAD(P)+ 6-oxidoreductase activity", "naloxone reductase activity", "reductase, naloxone"], "types": ["T044"], "canonical_name": "morphine 6-dehydrogenase activity", "definition": "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+. [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324167", "aliases": ["N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity", "N-acetyl-D-hexosamine dehydrogenase activity", "N-acetylhexosamine dehydrogenase activity"], "types": ["T044"], "canonical_name": "N-acetylhexosamine 1-dehydrogenase activity", "definition": "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + NAD(+) = N-acetyl-D-glucosaminate + 2 H(+) + NADH. [EC:1.1.1.240, RHEA:23144]"}
{"concept_id": "C1324168", "aliases": ["N-acetyl-D-mannosamine dehydrogenase activity", "N-acyl-D-mannosamine dehydrogenase activity", "N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity", "N-acylmannosamine dehydrogenase activity"], "types": ["T044"], "canonical_name": "N-acylmannosamine 1-dehydrogenase activity", "definition": "Catalysis of the reaction: N-acyl-D-mannosamine + NAD(+) = N-acyl-D-mannosaminolactone + H(+) + NADH. [EC:1.1.1.233, RHEA:11540]"}
{"concept_id": "C1324169", "aliases": ["10-hydroxydecanoate:NAD+ 10-oxidoreductase activity", "w-hydroxydecanoate dehydrogenase activity"], "types": ["T044"], "canonical_name": "omega-hydroxydecanoate dehydrogenase activity", "definition": "Catalysis of the reaction: 10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH. [EC:1.1.1.66, RHEA:20880]"}
{"concept_id": "C1324170", "aliases": ["D-glycerate:NAD(P)+ oxidoreductase (carboxylating)"], "types": ["T044"], "canonical_name": "oxaloglycolate reductase (decarboxylating) activity", "definition": "Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate. [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN]"}
{"concept_id": "C1324171", "aliases": ["D-pantoate:NAD+ 4-oxidoreductase activity", "(R)-pantoate:NAD+ 4-oxidoreductase activity", "pantoate dehydrogenase activity", "panthothenase activity"], "types": ["T044"], "canonical_name": "pantoate 4-dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH. [EC:1.1.1.106, RHEA:23000]"}
{"concept_id": "C1324172", "aliases": [], "types": ["T044"], "canonical_name": "propanediol-phosphate dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH. [EC:1.1.1.7, RHEA:21584]"}
{"concept_id": "C1324173", "aliases": ["(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity", "PGE-9-ketoreductase activity", "9-ketoprostaglandin reductase activity", "PGE(2) 9-oxoreductase activity", "prostaglandin-E2 9-oxoreductase activity", "PGE(2) 9-ketoreductase activity", "PGE2 9-ketoreductase activity", "prostaglandin-E(2) 9-oxoreductase activity", "PGE2-9-ketoreductase activity", "9-keto-prostaglandin E(2) reductase activity", "prostaglandin E 9-ketoreductase activity", "9-keto-prostaglandin E2 reductase activity", "prostaglandin E2-9-oxoreductase activity", "PGE2 9-oxoreductase activity", "reductase, 15-hydroxy-9-oxoprostaglandin"], "types": ["T044"], "canonical_name": "prostaglandin-E2 9-reductase activity", "definition": "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN]"}
{"concept_id": "C1324174", "aliases": ["prostaglandin-D(2) ketoreductase activity", "PGD2 11-ketoreductase activity", "prostaglandin 11-keto reductase activity", "prostaglandin 11-ketoreductase activity", "prostaglandin D2-ketoreductase activity", "prostaglandin-D(2) 11-reductase activity", "prostaglandin F synthetase activity", "PGF2alpha synthetase activity", "synthetase, prostaglandin F2alpha", "prostaglandin-F synthase activity", "PGD2 11-ketoreductase", "prostaglandin-F synthetase activity", "prostaglandin-D2 ketoreductase activity", "NADPH-dependent prostaglandin D2 11-keto reductase activity", "prostaglandin 11-keto reductase", "prostaglandin-D2 11-reductase activity", "prostaglandin F synthase activity", "prostaglandin-D(2) 11-ketoreductase activity", "PGD(2) 11-ketoreductase activity", "prostaglandin-D2 11-ketoreductase activity", "PGF synthetase activity", "reductase, 15-hydroxy-11-oxoprostaglandin", "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity"], "types": ["T044"], "canonical_name": "prostaglandin D2 11-ketoreductase activity", "definition": "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate. [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN]"}
{"concept_id": "C1324175", "aliases": ["pterocarpan synthase activity", "medicarpin:NADP+ 2'-oxidoreductase activity"], "types": ["T044"], "canonical_name": "pterocarpin synthase activity", "definition": "Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH. [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN]"}
{"concept_id": "C1324176", "aliases": ["pyridoxal dehydrogenase activity", "pyridoxal:NAD+ 4-oxidoreductase activity"], "types": ["T044"], "canonical_name": "pyridoxal 4-dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH. [EC:1.1.1.107, RHEA:21336]"}
{"concept_id": "C1324178", "aliases": ["adonitol dehydrogenase activity", "ribitol:NAD+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "ribitol 2-dehydrogenase activity", "definition": "Catalysis of the reaction: D-ribitol + NAD(+) = D-ribulose + H(+) + NADH. [EC:1.1.1.56, RHEA:20053]"}
{"concept_id": "C1324179", "aliases": ["D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity", "dehydrogenase, ribitol 5-phosphate"], "types": ["T044"], "canonical_name": "ribitol-5-phosphate 2-dehydrogenase activity", "definition": "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+. [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324180", "aliases": ["NADP-pentose-dehydrogenase activity", "D-ribose:NADP+ 1-oxidoreductase activity", "D-ribose dehydrogenase (NADP+)"], "types": ["T044"], "canonical_name": "ribose 1-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: H(2)O + NADP(+) + ribofuranose = D-ribonate + 2 H(+) + NADPH. [EC:1.1.1.115, RHEA:11676]"}
{"concept_id": "C1324181", "aliases": ["salutaridinol:NADP+ 7-oxidoreductase activity"], "types": ["T044"], "canonical_name": "salutaridine reductase (NADPH) activity", "definition": "Catalysis of the reaction: (7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine. [EC:1.1.1.248, RHEA:10108]"}
{"concept_id": "C1324182", "aliases": ["5-O-methyl-myo-inositol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "sequoyitol dehydrogenase activity", "definition": "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH. [EC:1.1.1.143, RHEA:11300]"}
{"concept_id": "C1324184", "aliases": ["L-sorbose:NADP+ 5-oxidoreductase activity", "5-keto-D-fructose reductase activity", "reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity", "5-ketofructose reductase activity", "sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity"], "types": ["T044"], "canonical_name": "sorbose 5-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH. [EC:1.1.1.123, RHEA:15001]"}
{"concept_id": "C1324185", "aliases": ["12alpha-hydroxy steroid dehydrogenase activity", "12alpha-hydroxysteroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "12-alpha-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C1324186", "aliases": ["12beta-hydroxysteroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "12-beta-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C1324187", "aliases": ["16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity", "16alpha-hydroxy steroid dehydrogenase activity", "16alpha-hydroxysteroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "16-alpha-hydroxysteroid dehydrogenase activity", "definition": "Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid. [EC:1.1.1.147, MetaCyc:1.1.1.147-RXN]"}
{"concept_id": "C1324188", "aliases": ["20alpha-HSD", "20alpha-hydroxysteroid dehydrogenase"], "types": ["T044"], "canonical_name": "20alpha-HSDH"}
{"concept_id": "C1324189", "aliases": [], "types": ["T044"], "canonical_name": "21-hydroxysteroid dehydrogenase (NAD+) activity"}
{"concept_id": "C1324190", "aliases": ["NADP-21-hydroxysteroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "21-hydroxysteroid dehydrogenase (NADP+) activity"}
{"concept_id": "C1324191", "aliases": ["3(or 17)alpha-hydroxysteroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "3(or 17)-alpha-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C1324192", "aliases": ["3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)"], "types": ["T044"], "canonical_name": "3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity"}
{"concept_id": "C1324193", "aliases": ["3alpha(or 20beta)-hydroxysteroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C1324194", "aliases": ["3alpha-hydroxysteroid dehydrogenase (A-specific)"], "types": ["T044"], "canonical_name": "3-alpha-hydroxysteroid dehydrogenase (A-specific) activity"}
{"concept_id": "C1324196", "aliases": ["3beta(or 20alpha)-hydroxysteroid dehydrogenase activity"], "types": ["T044"], "canonical_name": "3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C1324197", "aliases": ["NADP-dependent 7beta-hydroxysteroid dehydrogenase activity", "7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity", "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity", "7-beta-hydroxysteroid dehydrogenase (NADP+) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid. [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN]", "canonical_name": "7beta-hydroxysteroid dehydrogenase (NADP+)"}
{"concept_id": "C1324198", "aliases": ["17alpha-hydroxysteroid oxidoreductase activity", "estradiol 17a-dehydrogenase activity", "estradiol 17alpha-oxidoreductase activity", "17alpha-hydroxy steroid oxidoreductase activity", "estradiol 17alpha-dehydrogenase activity", "17alpha-hydroxy steroid dehydrogenase activity", "17alpha-estradiol dehydrogenase activity", "17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity"], "types": ["T044"], "canonical_name": "estradiol 17-alpha-dehydrogenase activity", "definition": "Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+. [EC:1.1.1.148, MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324199", "aliases": ["NADP-dependent testosterone-17beta-oxidoreductase activity", "17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity", "testosterone 17beta-dehydrogenase (NADP+)"], "types": ["T044"], "definition": "Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN]", "canonical_name": "testosterone 17-beta-dehydrogenase (NADP+) activity"}
{"concept_id": "C1324201", "aliases": ["3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity"], "types": ["T044"], "canonical_name": "sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity", "definition": "Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one. [EC:1.1.1.170, MetaCyc:1.1.1.170-RXN]"}
{"concept_id": "C1324202", "aliases": ["sulcatol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "sulcatone reductase activity", "definition": "Catalysis of the reaction: NAD(+) + sulcatol = H(+) + NADH + sulcatone. [EC:1.1.1.260, RHEA:24484]"}
{"concept_id": "C1324203", "aliases": ["T4HN reductase activity", "scytalone:NADP+ delta5-oxidoreductase activity"], "types": ["T044"], "canonical_name": "tetrahydroxynaphthalene reductase activity", "definition": "Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol. [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN]"}
{"concept_id": "C1324204", "aliases": ["tropine:NADP+ 3alpha-oxidoreductase activity"], "types": ["T044"], "canonical_name": "tropine dehydrogenase activity", "definition": "Catalysis of the reaction: NADP(+) + tropine = H(+) + NADPH + tropinone. [EC:1.1.1.206, RHEA:18357]"}
{"concept_id": "C1324205", "aliases": ["tropinone (psi-tropine-forming) reductase activity", "pseudotropine:NADP+ 3-oxidoreductase activity", "pseudotropine forming tropinone reductase activity"], "types": ["T044"], "canonical_name": "tropinone reductase activity", "definition": "Catalysis of the reaction: NADP(+) + pseudotropine = H(+) + NADPH + tropinone. [EC:1.1.1.236, RHEA:24244]"}
{"concept_id": "C1324206", "aliases": ["UDP-GLcNAc dehydrogenase activity", "UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity", "uridine diphosphoacetylglucosamine dehydrogenase activity", "UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity", "UDPacetylglucosamine dehydrogenase activity"], "types": ["T044"], "canonical_name": "UDP-N-acetylglucosamine 6-dehydrogenase activity", "definition": "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate. [EC:1.1.1.136, RHEA:13325]"}
{"concept_id": "C1324207", "aliases": ["uronate: NAD-oxidoreductase activity", "uronic acid dehydrogenase activity", "uronate:NAD+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "uronate dehydrogenase activity", "definition": "Catalysis of the reaction: D-galacturonate + H(2)O + NAD(+) = galactarate + 2 H(+) + NADH. [EC:1.1.1.203, RHEA:22404]"}
{"concept_id": "C1324208", "aliases": ["10-deoxysarpagine:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "vellosimine dehydrogenase activity", "definition": "Catalysis of the reaction: 10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine. [EC:1.1.1.273, RHEA:20029]"}
{"concept_id": "C1324209", "aliases": ["vomifoliol:NAD+ 4'-oxidoreductase activity"], "types": ["T044"], "canonical_name": "vomifoliol 4'-dehydrogenase activity", "definition": "Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH. [EC:1.1.1.221, RHEA:22804]"}
{"concept_id": "C1324210", "aliases": ["(R)-pantoyllactone dehydrogenase (flavin) activity", "2-dehydropantoyl-lactone reductase (flavin) activity", "2-dehydropantolactone reductase (flavin) activity", "(R)-pantolactone:acceptor oxidoreductase (flavin-containing)"], "types": ["T044"], "canonical_name": "(R)-pantolactone dehydrogenase (flavin) activity", "definition": "Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2). [EC:1.1.99.27, RHEA:21004]"}
{"concept_id": "C1324211", "aliases": ["(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase", "alpha-hydroxyglutarate oxidoreductase activity", "hydroxyglutaric dehydrogenase activity", "L-alpha-hydroxyglutarate dehydrogenase activity", "alpha-hydroxyglutarate dehydrogenase activity", "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase"], "types": ["T044"], "canonical_name": "2-hydroxyglutarate dehydrogenase activity", "definition": "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324212", "aliases": ["3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "3-hydroxycyclohexanone dehydrogenase activity", "definition": "Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione. [EC:1.1.99.26, RHEA:15905]"}
{"concept_id": "C1324213", "aliases": ["alkan-1-ol:(acceptor) oxidoreductase activity", "alkan-1-ol:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "alkan-1-ol dehydrogenase (acceptor) activity", "definition": "Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor. [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN]"}
{"concept_id": "C1324214", "aliases": ["cellobiose dehydrogenase activity", "cellobiose oxidase activity", "cellobiose oxidoreductase activity", "CBOR activity", "cellobiose:(acceptor) 1-oxidoreductase activity", "cellobiose:acceptor 1-oxidoreductase activity", "cellobiose:oxygen 1-oxidoreductase activity", "phanerochaete chrysosporium cellobiose oxidoreductase activity"], "types": ["T044"], "canonical_name": "cellobiose dehydrogenase (acceptor) activity", "definition": "Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor. [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN]"}
{"concept_id": "C1324215", "aliases": ["2-hydroxy acid dehydrogenase activity", "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "D-2-hydroxy-acid dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate. [EC:1.1.99.6, RHEA:15089]"}
{"concept_id": "C1324216", "aliases": ["D-sorbitol:acceptor 1-oxidoreductase activity", "D-sorbitol:(acceptor) 1-oxidoreductase activity", "D-sorbitol dehydrogenase activity"], "types": ["T044"], "canonical_name": "D-sorbitol dehydrogenase (acceptor) activity", "definition": "Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor. [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324217", "aliases": ["2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity", "ketogluconate dehydrogenase activity", "alpha-ketogluconate dehydrogenase activity", "2-keto-D-gluconate dehydrogenase activity", "2-oxogluconate dehydrogenase activity"], "types": ["T044"], "canonical_name": "dehydrogluconate dehydrogenase activity", "definition": "Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2). [EC:1.1.99.4, RHEA:12368]"}
{"concept_id": "C1324218", "aliases": ["D-fructose:(acceptor) 5-oxidoreductase activity", "fructose 5-dehydrogenase (acceptor)", "D-fructose:acceptor 5-oxidoreductase activity", "D-fructose dehydrogenase activity"], "types": ["T044"], "canonical_name": "fructose 5-dehydrogenase activity", "definition": "Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2). [EC:1.1.99.11, RHEA:22304]"}
{"concept_id": "C1324219", "aliases": ["D-glucose:D-fructose oxidoreductase activity"], "types": ["T044"], "canonical_name": "glucose-fructose oxidoreductase activity", "definition": "Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone. [EC:1.1.99.28, RHEA:20637]"}
{"concept_id": "C1324220", "aliases": ["glycerol:(acceptor) 1-oxidoreductase activity", "glycerol:acceptor 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "glycerol dehydrogenase (acceptor) activity", "definition": "Catalysis of the reaction: A + glycerol = AH(2) + glycerone. [EC:1.1.99.22, RHEA:17493]"}
{"concept_id": "C1324221", "aliases": ["transhydrogenase, hydroxy acid-oxo acid", "(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydroxyacid-oxoacid transhydrogenase activity", "definition": "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN]"}
{"concept_id": "C1324222", "aliases": ["(S)-lactate:oxaloacetate oxidoreductase activity", "malate-lactate transhydrogenase activity"], "types": ["T044"], "canonical_name": "lactate-malate transhydrogenase activity", "definition": "Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate. [EC:1.1.99.7, RHEA:10984]"}
{"concept_id": "C1324223", "aliases": [], "types": ["T044"], "canonical_name": "PVA dehydrogenase activity"}
{"concept_id": "C1324224", "aliases": ["pyridoxal-5-dehydrogenase activity", "pyridoxine 5'-dehydrogenase activity", "pyridoxine:(acceptor) 5-oxidoreductase activity", "pyridoxine:acceptor 5-oxidoreductase activity", "pyridoxol 5-dehydrogenase activity", "pyridoxin 5-dehydrogenase activity"], "types": ["T044"], "canonical_name": "pyridoxine 5-dehydrogenase activity", "definition": "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor. [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324226", "aliases": ["L-sorbose:(acceptor) 5-oxidoreductase activity", "L-sorbose:acceptor 5-oxidoreductase activity"], "types": ["T044"], "canonical_name": "sorbose dehydrogenase activity", "definition": "Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2). [EC:1.1.99.12, RHEA:14713]"}
{"concept_id": "C1324227", "aliases": [], "types": ["T044"], "canonical_name": "uracil dehydrogenase activity", "definition": "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor. [RHEA:22752]"}
{"concept_id": "C1324228", "aliases": ["(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity", "L-4-hydroxymandelate oxidase (decarboxylating)"], "types": ["T044"], "canonical_name": "4-hydroxymandelate oxidase activity", "definition": "Catalysis of the reaction: (S)-4-hydroxymandelate + H(+) + O(2) = 4-hydroxybenzaldehyde + CO(2) + H(2)O(2). [EC:1.1.3.19, RHEA:15833]"}
{"concept_id": "C1324229", "aliases": ["AOX activity", "alcohol:oxygen oxidoreductase activity", "ethanol oxidase activity"], "types": ["T044"], "canonical_name": "alcohol oxidase activity", "definition": "Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2. [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN]"}
{"concept_id": "C1324230", "aliases": ["aryl-alcohol:oxygen oxidoreductase activity", "aryl alcohol oxidase activity", "arom. alcohol oxidase activity"], "types": ["T044"], "canonical_name": "aryl-alcohol oxidase activity", "definition": "Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2. [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN]"}
{"concept_id": "C1324231", "aliases": ["catechol:oxygen oxidoreductase (dimerizing)"], "types": ["T044"], "canonical_name": "catechol oxidase (dimerizing) activity", "definition": "Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O. [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN]"}
{"concept_id": "C1324233", "aliases": ["mannitol:oxygen oxidoreductase (cyclizing)", "D-arabitol oxidase activity", "mannitol oxidase activity"], "types": ["T044"], "canonical_name": "D-mannitol oxidase activity", "definition": "Catalysis of the reaction: mannitol + O2 = mannose + H2O2. [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN]"}
{"concept_id": "C1324234", "aliases": ["ecdysone:oxygen 3-oxidoreductase activity", "beta-ecdysone oxidase activity"], "types": ["T044"], "canonical_name": "ecdysone oxidase activity", "definition": "Catalysis of the reaction: Ecdysone + O(2) = 3-dehydroecdysone + H(2)O(2). [EC:1.1.3.16, RHEA:11796]"}
{"concept_id": "C1324235", "aliases": ["D-hexose:oxygen 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "hexose oxidase activity", "definition": "Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202. [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN]"}
{"concept_id": "C1324236", "aliases": [], "types": ["T044"], "canonical_name": "hydroxyphytanate oxidase activity", "definition": "Catalysis of the reaction: (2S)-2-hydroxyphytanate + O(2) = 2-oxophytanate + H(2)O(2). [EC:1.1.3.27, RHEA:21680]"}
{"concept_id": "C1324237", "aliases": ["L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity", "L-xylono-1,4-lactone oxidase activity", "L-galactono-1,4-lactone oxidase activity"], "types": ["T044"], "canonical_name": "L-galactonolactone oxidase activity", "definition": "Catalysis of the reaction: L-galactono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2) + H(+). [EC:1.3.3.12, RHEA:20617]"}
{"concept_id": "C1324238", "aliases": ["L-gulono-gamma-lactone:O2 oxidoreductase activity", "L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity", "L-gulono-gamma-lactone oxidase activity", "GLO activity", "L-gulono-gamma-lactone:oxidoreductase activity"], "types": ["T044"], "canonical_name": "L-gulonolactone oxidase activity", "definition": "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2. [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN, RHEA:32363]"}
{"concept_id": "C1324239", "aliases": ["L-sorbose:oxygen 5-oxidoreductase activity"], "types": ["T044"], "canonical_name": "L-sorbose oxidase activity", "definition": "Catalysis of the reaction: L-sorbose + O(2) = 5-dehydro-D-fructose + H(2)O(2). [EC:1.1.3.11, RHEA:17853]"}
{"concept_id": "C1324240", "aliases": ["N-acyl-D-hexosamine oxidase activity", "N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity", "N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "N-acylhexosamine oxidase activity", "definition": "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + O(2) = N-acetyl-D-glucosaminate + H(2)O(2) + H(+). [EC:1.1.3.29, RHEA:13029]"}
{"concept_id": "C1324241", "aliases": ["polyvinyl alcohol oxidase activity", "secondary-alcohol oxidase activity", "polyvinyl-alcohol:oxygen oxidoreductase activity", "secondary alcohol oxidase activity", "secondary-alcohol:oxygen oxidoreductase activity", "PVA oxidase activity", "dehydrogenase, polyvinyl alcohol"], "types": ["T044"], "canonical_name": "polyvinyl-alcohol oxidase activity", "definition": "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2. [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN]"}
{"concept_id": "C1324242", "aliases": ["pyranose-2-oxidase activity", "pyranose:oxygen 2-oxidoreductase activity", "glucose 2-oxidase activity"], "types": ["T044"], "canonical_name": "pyranose oxidase activity", "definition": "Catalysis of the reaction: D-glucose + O(2) = 2-dehydro-D-glucose + H(2)O(2). [EC:1.1.3.10, RHEA:10552]"}
{"concept_id": "C1324243", "aliases": ["pyridoxol 4-oxidase activity", "pyridoxine:oxygen 4-oxidoreductase activity", "pyridoxin 4-oxidase activity"], "types": ["T044"], "canonical_name": "pyridoxine 4-oxidase activity", "definition": "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2. [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN]"}
{"concept_id": "C1324245", "aliases": ["xylitol:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "xylitol oxidase activity", "definition": "Catalysis of the reaction: xylitol + O2 = xylose + H2O2. [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN]"}
{"concept_id": "C1324246", "aliases": ["CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity", "CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity", "CDP-4-keto-6-deoxyglucose reductase activity", "CDP-4-keto-deoxy-glucose reductase activity", "cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity", "cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity", "NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity"], "types": ["T044"], "canonical_name": "CDP-4-dehydro-6-deoxyglucose reductase activity", "definition": "Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose. [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN]"}
{"concept_id": "C1324247", "aliases": ["2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)"], "types": ["T044"], "canonical_name": "pteridine oxidase activity", "definition": "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown. [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN]"}
{"concept_id": "C1324248", "aliases": ["L-ascorbate:ferricytochrome-b5 oxidoreductase activity", "L-ascorbate-cytochrome-b5 reductase activity", "ascorbate-cytochrome b5 reductase activity"], "types": ["T044"], "canonical_name": "transmembrane ascorbate ferrireductase activity", "definition": "Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction. [PMID:16911521, PMID:24449903, RHEA:30403]"}
{"concept_id": "C1324249", "aliases": ["trans-1,2-acenaphthenediol dehydrogenase activity", "(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "trans-acenaphthene-1,2-diol dehydrogenase activity", "definition": "Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH. [EC:1.10.1.1, RHEA:22184]"}
{"concept_id": "C1324250", "aliases": ["3-hydroxyanthranilate:oxygen oxidoreductase activity", "3-hydroxyanthranilic acid oxidase activity"], "types": ["T044"], "canonical_name": "3-hydroxyanthranilate oxidase activity", "definition": "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H(2)O(2). [EC:1.10.3.5, RHEA:17245]"}
{"concept_id": "C1324251", "aliases": ["o-aminophenol:O2 oxidoreductase activity", "2-aminophenol:O2 oxidoreductase activity", "isophenoxazine synthase activity", "GriF", "o-aminophenol oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O. [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN]", "canonical_name": "2-aminophenol:oxygen oxidoreductase activity"}
{"concept_id": "C1324252", "aliases": ["rifamycin-B:oxygen oxidoreductase activity", "rifamycin-B-oxidase activity", "rifamycin B oxidase activity"], "types": ["T044"], "canonical_name": "rifamycin-B oxidase activity", "definition": "Catalysis of the reaction: 2 H(+) + O(2) + rifamycin B = H(2)O(2) + rifamycin O. [EC:1.10.3.6, RHEA:11292]"}
{"concept_id": "C1324253", "aliases": ["ferrocytochrome:nitrate oxidoreductase activity", "benzyl viologen-nitrate reductase activity"], "types": ["T044"], "canonical_name": "nitrate reductase (cytochrome) activity", "definition": "Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite. [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN]"}
{"concept_id": "C1324254", "aliases": ["ferrocytochrome-c:Fe3+ oxidoreductase activity", "iron-cytochrome c reductase activity"], "types": ["T044"], "canonical_name": "iron-cytochrome-c reductase activity", "definition": "Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+. [EC:1.9.98.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN]"}
{"concept_id": "C1324255", "aliases": ["H(2):ferricytochrome c3 oxidoreductase activity", "hydrogen:ferricytochrome-c3 oxidoreductase activity", "cytochrome c3 reductase activity", "H2:ferricytochrome c3 oxidoreductase activity"], "types": ["T044"], "canonical_name": "cytochrome-c3 hydrogenase activity", "definition": "Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3. [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN]"}
{"concept_id": "C1324256", "aliases": ["hydrogen:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydrogen dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: NADP+ + H2 = NADPH + H+. [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN]"}
{"concept_id": "C1324257", "aliases": ["H(2):NAD(+) oxidoreductase activity", "NAD-linked hydrogenase activity", "H2:NAD+ oxidoreductase activity", "hydrogen:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydrogen dehydrogenase activity", "definition": "Catalysis of the reaction: H2 + NAD+ = H+ + NADH. [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324258", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound. [GOC:jl]"}
{"concept_id": "C1324259", "aliases": ["hydrogen:menaquinone oxidoreductase activity", "hydrogen-ubiquinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydrogen:quinone oxidoreductase activity", "definition": "Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone. [EC:1.12.5.1, RHEA:18641]"}
{"concept_id": "C1324260", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on hydrogen as donor, with other known acceptors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound. [GOC:ai]"}
{"concept_id": "C1324261", "aliases": ["hydrogen:coenzyme F420 oxidoreductase activity", "coenzyme F420-dependent hydrogenase activity", "8-hydroxy-5-deazaflavin-reducing hydrogenase activity", "F420-reducing hydrogenase activity"], "types": ["T044"], "canonical_name": "coenzyme F420 hydrogenase activity", "definition": "Catalysis of the reaction: coenzyme F420 + H(2) + H(+) = reduced coenzyme F420. [EC:1.12.98.1, RHEA:23760]"}
{"concept_id": "C1324262", "aliases": ["hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity", "N5,N10-methylenetetrahydromethanopterin dehydrogenase activity", "hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity", "H(2)-dependent methylene-H(4)MPT dehydrogenase activity", "H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity", "N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity", "5,10-methenyltetrahydromethanopterin hydrogenase activity", "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity", "hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity", "H2-dependent methylene-H4MPT dehydrogenase activity"], "types": ["T044"], "canonical_name": "N5,N10-methenyltetrahydromethanopterin hydrogenase activity", "definition": "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H(+). [EC:1.12.98.2, RHEA:20017]"}
{"concept_id": "C1324263", "aliases": ["cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)", "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)", "NADPH:ferricytochrome-c2 oxidoreductase activity"], "types": ["T044"], "canonical_name": "NADPH-cytochrome-c2 reductase activity", "definition": "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2. [EC:1.6.2.5]"}
{"concept_id": "C1324264", "aliases": ["reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity", "D-diaphorase activity", "NADH:(quinone-acceptor) oxidoreductase activity", "NADH-quinone oxidoreductase activity", "DPNH-menadione reductase activity"], "types": ["T044"], "canonical_name": "NADH dehydrogenase (quinone) activity", "definition": "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. [EC:1.6.5.11, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN]"}
{"concept_id": "C1324265", "aliases": ["1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity", "2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity", "NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity", "hydroxybenzoquinone reductase activity", "1,2,4-trihydroxybenzene:NAD oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-hydroxy-1,4-benzoquinone reductase activity", "definition": "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+). [EC:1.6.5.7, RHEA:12428]"}
{"concept_id": "C1324266", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor"}
{"concept_id": "C1324268", "aliases": ["[nitrite reductase (cytochrome)]", "cytochrome c-551:O2, NO2+ oxidoreductase activity", "nitrite reductase (cytochrome; NO-forming) activity", "NO-forming nitrite reductase (cytochrome) activity", "nitrite reductase (NO-forming) activity", "NO-forming nitrite reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+. [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN]", "canonical_name": "nitric-oxide:ferricytochrome-c oxidoreductase activity"}
{"concept_id": "C1324269", "aliases": ["TOR activity", "TMAO reductase activity", "trimethylamine:cytochrome c oxidoreductase activity"], "types": ["T044"], "canonical_name": "trimethylamine-N-oxide reductase (cytochrome c) activity", "definition": "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+. [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN]"}
{"concept_id": "C1324270", "aliases": ["nitrate (ferredoxin) reductase activity", "nitrite:ferredoxin oxidoreductase activity", "assimilatory ferredoxin-nitrate reductase activity"], "types": ["T044"], "canonical_name": "ferredoxin-nitrate reductase activity", "definition": "Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin. [EC:1.7.7.2, MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN]"}
{"concept_id": "C1324271", "aliases": ["ammonia:(acceptor) oxidoreductase activity", "hydroxylamine (acceptor) reductase activity", "ammonia:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydroxylamine reductase activity", "definition": "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor. [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN]"}
{"concept_id": "C1324272", "aliases": ["nitrogen:acceptor oxidoreductase (N2O-forming)", "nitrous oxide reductase activity", "N2O reductase activity", "nitrogen:(acceptor) oxidoreductase (N2O-forming)"], "types": ["T044"], "canonical_name": "nitrous-oxide reductase activity", "definition": "Catalysis of the reaction: H(2)O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide. [EC:1.7.2.4, MetaCyc:RXN-12130]"}
{"concept_id": "C1324273", "aliases": ["3-aci-nitropropanoate:oxygen oxidoreductase activity", "propionate-3-nitronate oxidase activity"], "types": ["T044"], "canonical_name": "3-aci-nitropropanoate oxidase activity", "definition": "Catalysis of the reaction: 3-aci-nitropropanoate + H(2)O + O(2) = 3-oxopropanoate + H(2)O(2) + nitrite. [EC:1.7.3.5, RHEA:22372]"}
{"concept_id": "C1324274", "aliases": ["N-acetylindoxyl:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "acetylindoxyl oxidase activity", "definition": "Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown. [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN]"}
{"concept_id": "C1324275", "aliases": ["HAO", "hydroxylamine oxidoreductase", "hydroxylamine oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: hydroxylamine + O(2) = H(2)O + H(+) + nitrite. [RHEA:19969]", "canonical_name": "hydroxylamine:oxygen oxidoreductase activity"}
{"concept_id": "C1324276", "aliases": ["nitroethane:oxygen oxidoreductase activity", "nitroethane reductase activity"], "types": ["T044"], "canonical_name": "nitroethane oxidase activity", "definition": "Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2. [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN]"}
{"concept_id": "C1324277", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]"}
{"concept_id": "C1324278", "aliases": ["NADPH-dependent DMAB N-oxide reductase activity", "NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity", "4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity", "N,N-dimethyl-p-aminoazobenzene oxide reductase activity", "NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity", "dimethylaminoazobenzene N-oxide reductase activity"], "types": ["T044"], "canonical_name": "4-(dimethylamino)phenylazoxybenzene reductase activity", "definition": "Catalysis of the reaction: 4-(dimethylamino)azobenzene + H(2)O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH. [EC:1.7.1.11, RHEA:19789]"}
{"concept_id": "C1324279", "aliases": ["NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity", "NADPH2-dependent azoreductase activity", "p-aminoazobenzene reductase activity", "N,N-dimethyl-4-phenylazoaniline azoreductase activity", "N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity", "NADPH:4-(dimethylamino)azobenzene oxidoreductase activity", "NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity", "p-dimethylaminoazobenzene azoreductase activity", "dibromopropylaminophenylazobenzoic azoreductase activity", "nicotinamide adenine dinucleotide (phosphate) azoreductase activity", "dimethylaminobenzene reductase activity"], "types": ["T044"], "canonical_name": "azobenzene reductase activity", "definition": "Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+. [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN]"}
{"concept_id": "C1324280", "aliases": ["NADH:hydroxylamine oxidoreductase activity", "ammonium:NAD+ oxidoreductase activity", "NADH2:hydroxylamine oxidoreductase activity", "hydroxylamine reductase (NADH2)", "N-hydroxy amine reductase activity", "ammonium dehydrogenase activity", "NADH-hydroxylamine reductase activity"], "types": ["T044"], "canonical_name": "hydroxylamine reductase (NADH) activity", "definition": "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+. [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN]"}
{"concept_id": "C1324281", "aliases": ["hydroxylamine:NAD+ oxidoreductase activity", "NADH:hyponitrite oxidoreductase activity", "NADH2:hyponitrite oxidoreductase activity"], "types": ["T044"], "canonical_name": "hyponitrite reductase activity", "definition": "Catalysis of the reaction: 2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH. [EC:1.7.1.5, RHEA:19337]"}
{"concept_id": "C1324282", "aliases": ["N-hydroxy-2-acetylaminofluorene reductase activity", "2-acetamidofluorene:NAD(P)+ oxidoreductase activity", "NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity", "NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity"], "types": ["T044"], "canonical_name": "N-hydroxy-2-acetamidofluorene reductase activity", "definition": "Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+. [EC:1.7.1.12, MetaCyc:1.7.1.12-RXN]"}
{"concept_id": "C1324284", "aliases": ["NAD(P)H bispecific nitrate reductase activity", "assimilatory NADPH-nitrate reductase activity", "triphosphopyridine nucleotide-nitrate reductase activity", "NADPH:nitrate oxidoreductase activity", "nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity", "assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity", "NADPH-nitrate reductase activity", "nitrite:NAD(P)+ oxidoreductase activity", "NAD(P)H2:nitrate oxidoreductase activity", "nitrate reductase (NADPH(2)) activity", "NAD(P)H-nitrate reductase activity", "nitrate reductase (NADPH) activity", "NAD(P)H:nitrate oxidoreductase activity", "NADPH:nitrate reductase activity", "nitrate reductase NAD(P)H activity", "nitrate reductase (NADPH2)", "nitrite:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "nitrate reductase [NAD(P)H] activity", "definition": "Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+. [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN]"}
{"concept_id": "C1324285", "aliases": ["nitrite reductase NADPH activity", "NADH-nitrite oxidoreductase activity", "NAD(P)H:nitrite oxidoreductase activity", "nitrite reductase [NAD(P)H] activity", "NAD(P)H2:nitrite oxidoreductase activity", "NADPH-nitrite reductase activity", "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+. [EC:1.7.1.4, PMID:31961593]", "canonical_name": "ammonium-hydroxide:NAD(P)+ oxidoreductase activity"}
{"concept_id": "C1324286", "aliases": ["NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity", "4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity", "4-nitroquinoline 1-oxide reductase activity", "4NQO reductase activity", "NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity"], "types": ["T044"], "canonical_name": "nitroquinoline-N-oxide reductase activity", "definition": "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+. [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN]"}
{"concept_id": "C1324287", "aliases": ["TCE-reductive dehalogenase activity", "1,1,2-trichloroethylene reductive dehalogenase activity"], "types": ["T044"], "canonical_name": "1,1,2-trichloroethene reductive dehalogenase activity", "definition": "Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene. [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271]"}
{"concept_id": "C1324288", "aliases": ["chlorite:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "chlorate reductase activity", "definition": "Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H(2)O + H(+). [EC:1.97.1.1, RHEA:16349]"}
{"concept_id": "C1324289", "aliases": ["2,4,6-TCP reductive dehalogenase activity", "2,4,6-trichlorophenol reductive dehalogenase activity"], "types": ["T044"], "canonical_name": "ortho-trichlorophenol reductive dehalogenase activity", "definition": "Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl. [GOC:ai, PMID:12697029]"}
{"concept_id": "C1324290", "aliases": ["tetrachloroethene reductase activity", "acceptor:trichloroethene oxidoreductase (chlorinating)"], "types": ["T044"], "canonical_name": "tetrachloroethene reductive dehalogenase activity", "definition": "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor. [EC:1.21.99.5, MetaCyc:1.97.1.8-RXN]"}
{"concept_id": "C1324291", "aliases": [], "types": ["T044"], "canonical_name": "2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity", "definition": "Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2. [UM-BBD_reactionID:r0274]"}
{"concept_id": "C1324292", "aliases": ["6beta-hydroxyhyoscyamine epoxidase activity", "hydroxyhyoscyamine dioxygenase activity", "(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)"], "types": ["T044"], "canonical_name": "6-beta-hydroxyhyoscyamine epoxidase activity", "definition": "Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O(2) = CO(2) + H(2)O + H(+) + scopolamine + succinate. [EC:1.14.20.13, RHEA:12797]"}
{"concept_id": "C1324293", "aliases": ["desacetoxyvindoline-4-hydroxylase activity", "desacetyoxyvindoline-17-hydroxylase activity", "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity", "deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)", "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)", "D17H activity"], "types": ["T044"], "canonical_name": "desacetoxyvindoline 4-hydroxylase activity", "definition": "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2. [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN]"}
{"concept_id": "C1324294", "aliases": ["oxygenase, gibberellin A44 oxidase activity", "(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity", "gibberellin A44 oxidase activity", "(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "gibberellin-44 dioxygenase activity", "definition": "Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2. [EC:1.14.11.12, MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN]"}
{"concept_id": "C1324295", "aliases": ["hyoscyamine 6-hydroxylase activity", "hyoscyamine (6S)-hydroxylase activity", "L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)", "hyoscyamine 6beta-dioxygenase activity", "hyoscyamine 6beta-hydroxylase activity", "hyoscyamine 6-beta-hydroxylase activity"], "types": ["T044"], "canonical_name": "hyoscyamine (6S)-dioxygenase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O(2) = (6S)-6-hydroxyhyoscyamine + CO(2) + succinate. [EC:1.14.11.11, RHEA:12629]"}
{"concept_id": "C1324297", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine-deoxynucleoside 1'-dioxygenase activity"}
{"concept_id": "C1324298", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine-deoxynucleoside 2'-dioxygenase activity"}
{"concept_id": "C1324299", "aliases": ["sulfonate/alpha-ketoglutarate dioxygenase activity", "sulphonate dioxygenase activity"], "types": ["T044"], "canonical_name": "sulfonate dioxygenase activity", "definition": "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2. [GOC:clt, PMID:10482536]"}
{"concept_id": "C1324300", "aliases": ["2-aminoethanesulfonate dioxygenase activity", "alpha-ketoglutarate-dependent taurine dioxygenase activity", "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)"], "types": ["T044"], "canonical_name": "taurine dioxygenase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite. [EC:1.14.11.17, RHEA:15909]"}
{"concept_id": "C1324301", "aliases": ["5-hydroxy-methyluracil dioxygenase activity", "5-hydroxymethyluracil oxygenase activity", "thymine,2-oxoglutarate dioxygenase activity", "thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)", "thymine 7-hydroxylase activity"], "types": ["T044"], "canonical_name": "thymine dioxygenase activity", "definition": "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2. [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN]"}
{"concept_id": "C1324302", "aliases": ["TML hydroxylase activity", "TML dioxygenase activity", "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity", "trimethyllysine alpha-ketoglutarate dioxygenase activity", "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)", "TMLD activity", "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)", "TML-alpha-ketoglutarate dioxygenase activity", "trimethyllysine,2-oxoglutarate dioxygenase activity"], "types": ["T044"], "canonical_name": "trimethyllysine dioxygenase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate. [EC:1.14.11.8, RHEA:14181]"}
{"concept_id": "C1324303", "aliases": ["2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)", "2-hydroxypyridine oxygenase activity"], "types": ["T044"], "canonical_name": "2-hydroxypyridine 5-monooxygenase activity", "definition": "Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O(2) = 2,5-dihydroxypyridine + A + H(2)O. [EC:1.14.99.26, RHEA:16973]"}
{"concept_id": "C1324304", "aliases": ["3-HBA-2-hydroxylase activity", "3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)", "3-hydroxybenzoate 2-hydroxylase activity"], "types": ["T044"], "canonical_name": "3-hydroxybenzoate 2-monooxygenase activity", "definition": "Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O(2) = 2,3-dihydroxybenzoate + A + H(2)O. [EC:1.14.99.23, RHEA:14193]"}
{"concept_id": "C1324305", "aliases": ["androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)", "androstene-3,17-dione hydroxylase activity", "androst-4-ene-3,17-dione hydroxylase activity", "androstenedione monooxygenase activity", "androst-4-ene-3,17-dione 17-oxidoreductase activity", "4-androstene-3,17-dione monooxygenase activity"], "types": ["T044"], "canonical_name": "androst-4-ene-3,17-dione monooxygenase activity", "definition": "Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O(2) = A + H(2)O + testololactone. [EC:1.14.99.12, RHEA:22696]"}
{"concept_id": "C1324306", "aliases": ["estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)", "estradiol 6-beta-hydroxylase activity", "estradiol 6b-monooxygenase activity", "estradiol 6b-hydroxylase activity", "estradiol 6beta-monooxygenase activity", "estradiol 6beta-hydroxylase activity"], "types": ["T044"], "canonical_name": "estradiol 6-beta-monooxygenase activity", "definition": "Catalysis of the reaction: AH(2) + estradiol-17beta + O(2) = 6beta-hydroxyestradiol-17beta + A + H(2)O. [EC:1.14.99.11, RHEA:19137]"}
{"concept_id": "C1324307", "aliases": ["juglone hydroxylase activity", "5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)", "naphthoquinone hydroxylase activity", "juglone 3-monooxygenase activity"], "types": ["T044"], "canonical_name": "juglone 3-hydroxylase activity", "definition": "Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+. [PMID:4041238, RHEA:18745]"}
{"concept_id": "C1324308", "aliases": ["kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)", "kynurenate 7,8-hydroxylase activity", "kynurenic hydroxylase activity", "kynurenic acid hydroxylase activity"], "types": ["T044"], "canonical_name": "kynurenine 7,8-hydroxylase activity", "definition": "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor. [EC:1.14.99.2, MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN]"}
{"concept_id": "C1324309", "aliases": ["Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)", "luciferase (Latia luciferin)", "Latia luciferin monooxygenase (demethylating)"], "types": ["T044"], "canonical_name": "Latia-luciferin monooxygenase (demethylating) activity", "definition": "Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin. [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN]"}
{"concept_id": "C1324310", "aliases": ["3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating)"], "types": ["T044"], "canonical_name": "linalool 8-monooxygenase activity", "definition": "Catalysis of the reaction: AH(2) + linalool + O(2) = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H(2)O. [EC:1.14.14.84, RHEA:32635]"}
{"concept_id": "C1324312", "aliases": [], "types": ["T044"], "canonical_name": "myristoyl-CoA 11-(E) desaturase activity", "definition": "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O. [RHEA:46396]"}
{"concept_id": "C1324313", "aliases": [], "types": ["T044"], "canonical_name": "myristoyl-CoA 11-(Z) desaturase activity", "definition": "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O. [RHEA:25852]"}
{"concept_id": "C1324314", "aliases": [], "types": ["T044"], "canonical_name": "16:0 monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule. [GOC:mah, MetaCyc:RXN-1728, MetaCyc:RXN-8304, MetaCyc:RXN-8307]"}
{"concept_id": "C1324315", "aliases": ["phylloquinone epoxidase activity", "vitamin K 2,3-epoxidase activity", "vitamin K epoxidase activity", "vitamin K1 epoxidase activity", "phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)"], "types": ["T044"], "canonical_name": "phylloquinone monooxygenase (2,3-epoxidizing) activity", "definition": "Catalysis of the reaction: AH(2) + O(2) + phylloquinone = 2,3-epoxyphylloquinone + A + H(2)O. [EC:1.14.99.20, RHEA:16745]"}
{"concept_id": "C1324316", "aliases": ["O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity", "alkylacylglycerophosphoethanolamine desaturase activity", "1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity", "dehydrogenase, alkyl-acylglycerophosphorylethanolamine", "plasmenylethanolamine desaturase activity", "1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity", "alkylacylglycero-phosphorylethanolamine dehydrogenase activity"], "types": ["T044"], "canonical_name": "plasmanylethanolamine desaturase activity", "definition": "Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O. [RHEA:22956]"}
{"concept_id": "C1324317", "aliases": ["progesterone 11alpha-monooxygenase activity", "progesterone 11alpha-hydroxylase activity", "progesterone 11a-monooxygenase activity", "progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)", "progesterone 11-alpha-hydroxylase activity"], "types": ["T044"], "canonical_name": "progesterone 11-alpha-monooxygenase activity", "definition": "Catalysis of the reaction: AH(2) + O(2) + progesterone = 11alpha-hydroxyprogesterone + A + H(2)O. [EC:1.14.99.14, RHEA:18205]"}
{"concept_id": "C1324318", "aliases": ["progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)", "progesterone hydroxylase activity"], "types": ["T044"], "canonical_name": "progesterone monooxygenase activity", "definition": "Catalysis of the reaction: AH(2) + O(2) + progesterone = A + H(2)O + testosterone acetate. [EC:1.14.99.4, RHEA:11984]"}
{"concept_id": "C1324319", "aliases": ["steroid 9alpha-monooxygenase activity", "steroid 9-alpha-hydroxylase activity", "steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)", "steroid 9alpha-hydroxylase activity", "steroid 9a-monooxygenase activity"], "types": ["T044"], "canonical_name": "steroid 9-alpha-monooxygenase activity", "definition": "Catalysis of the reaction: AH(2) + O(2) + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H(2)O. [EC:1.14.99.24, RHEA:19557]"}
{"concept_id": "C1324320", "aliases": ["taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)", "taxadiene 5alpha-hydroxylase activity", "taxadiene 5a-hydroxylase activity"], "types": ["T044"], "canonical_name": "taxadiene 5-alpha-hydroxylase activity", "definition": "Catalysis of the reaction: AH(2) + O(2) + taxa-4,11-diene = A + H(2)O + taxa-4(20),11-dien-5alpha-ol. [RHEA:14049]"}
{"concept_id": "C1324321", "aliases": ["thiophene-2-carboxyl-CoA dehydrogenase activity", "thiophene-2-carboxyl-CoA hydroxylase activity", "thiophene-2-carboxyl-CoA monooxygenase activity", "thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "thiophene-2-carbonyl-CoA monooxygenase activity", "definition": "Catalysis of the reaction: AH(2) + O(2) + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(2)O + H(+). [EC:1.14.99.35, RHEA:18929]"}
{"concept_id": "C1324322", "aliases": ["(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)", "l-menthol monooxygenase activity"], "types": ["T044"], "canonical_name": "(-)-menthol monooxygenase activity", "definition": "Catalysis of the reaction: (-)-menthol + H(+) + NADPH + O(2) = 1,4-menthane-3,8-diol + H(2)O + NADP(+). [EC:1.14.13.46, RHEA:11648]"}
{"concept_id": "C1324323", "aliases": ["2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)"], "types": ["T044"], "canonical_name": "2-hydroxybiphenyl 3-monooxygenase activity", "definition": "Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+). [RHEA:11996]"}
{"concept_id": "C1324324", "aliases": ["2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)"], "types": ["T044"], "canonical_name": "2-hydroxycyclohexanone 2-monooxygenase activity", "definition": "Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O(2) = 6-oxohexanoate + H(2)O + NADP(+). [EC:1.14.13.66, RHEA:33283]"}
{"concept_id": "C1324325", "aliases": ["2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)", "2-nitrophenol oxygenase activity"], "types": ["T044"], "canonical_name": "2-nitrophenol 2-monooxygenase activity", "definition": "Catalysis of the reaction: 2-nitrophenol + 2 H(+) + 2 NADPH + O(2) = catechol + H(2)O + 2 NADP(+) + nitrite. [EC:1.14.13.31, RHEA:19457]"}
{"concept_id": "C1324326", "aliases": ["27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)", "27-hydroxycholesterol 7a-hydroxylase activity", "27-hydroxycholesterol 7-alpha-hydroxylase activity", "27-hydroxycholesterol 7alpha-hydroxylase activity", "27-hydroxycholesterol 7alpha-monooxygenase activity"], "types": ["T044"], "canonical_name": "27-hydroxycholesterol 7-alpha-monooxygenase activity", "definition": "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol. [RHEA:24308]"}
{"concept_id": "C1324327", "aliases": ["3,9-dihydroxypterocarpan 6a-hydroxylase activity", "(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)"], "types": ["T044"], "canonical_name": "3,9-dihydroxypterocarpan 6a-monooxygenase activity", "definition": "Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H(+) + NADPH + O(2) = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(2)O + NADP(+). (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol. [EC:1.14.14.93, RHEA:15321]"}
{"concept_id": "C1324328", "aliases": ["3-hydroxyphenylacetate 6-monooxygenase activity", "3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)"], "types": ["T044"], "canonical_name": "3-hydroxyphenylacetate 6-hydroxylase activity", "definition": "Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate. [EC:1.14.13.63, MetaCyc:1.14.13.63-RXN]"}
{"concept_id": "C1324329", "aliases": ["4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity", "cytochrome P450II-dependent monooxygenase activity", "cytochrome P450-II-dependent monooxygenase activity", "(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity", "4-hydroxybenzeneacetaldehyde oxime monooxygenase activity", "NADPH-cytochrome P450 reductase (CYP71E1)"], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetaldehyde oxime monooxygenase activity", "definition": "Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+). [EC:1.14.14.37, RHEA:18401]"}
{"concept_id": "C1324330", "aliases": ["quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)", "1-H-4-oxoquinoline 3-monooxygenase activity", "quinolin-4(1H)-one 3-monooxygenase activity"], "types": ["T044"], "canonical_name": "4-hydroxyquinoline 3-monooxygenase activity", "definition": "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-4-ol = H(2)O + NAD(+) + quinoline-3,4-diol. [EC:1.14.13.62, RHEA:19325]"}
{"concept_id": "C1324331", "aliases": ["5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity", "trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)", "coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity"], "types": ["T044"], "canonical_name": "5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity", "definition": "Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate. [EC:1.14.14.96, MetaCyc:1.14.13.36-RXN]"}
{"concept_id": "C1324332", "aliases": ["6-oxocineole,NADPH:oxygen oxidoreductase activity", "6-oxocineole oxygenase activity"], "types": ["T044"], "canonical_name": "6-oxocineole dehydrogenase activity", "definition": "Catalysis of the reaction: 6-oxocineole + H(+) + NADPH + O(2) = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H(2)O + NADP(+). [EC:1.14.13.51, RHEA:24324]"}
{"concept_id": "C1324333", "aliases": ["7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)"], "types": ["T044"], "canonical_name": "7-deoxyloganin 7-hydroxylase activity", "definition": "Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O. [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN]"}
{"concept_id": "C1324334", "aliases": ["albendazole sulfoxidase activity", "albendazole oxidase activity", "albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)"], "types": ["T044"], "canonical_name": "albendazole monooxygenase activity", "definition": "Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+). [EC:1.14.13.32, RHEA:10796]"}
{"concept_id": "C1324335", "aliases": ["anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)", "ATC oxygenase activity", "anhydrotetracycline oxygenase activity"], "types": ["T044"], "canonical_name": "anhydrotetracycline monooxygenase activity", "definition": "Catalysis of the reaction: anhydrotetracycline + H(+) + NADPH + O(2) = 12-dehydrotetracycline + H(2)O + NADP(+). [EC:1.14.13.38, RHEA:11976]"}
{"concept_id": "C1324336", "aliases": ["benzoyl-CoA 3-hydroxylase activity", "benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)"], "types": ["T044"], "canonical_name": "benzoyl-CoA 3-monooxygenase activity", "definition": "Catalysis of the reaction: benzoyl-CoA + H(+) + NADPH + O(2) = 3-hydroxybenzoyl-CoA + H(2)O + NADP(+). [EC:1.14.13.58, RHEA:23216]"}
{"concept_id": "C1324337", "aliases": ["5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)", "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity", "5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity", "CYP27A", "cholestanetriol 26-hydroxylase activity", "5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity", "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity"], "types": ["T044"], "canonical_name": "cholestanetriol 26-monooxygenase activity", "definition": "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O. [EC:1.14.15.15, MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN]"}
{"concept_id": "C1324338", "aliases": ["cyclopentanone oxygenase activity", "cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)", "cyclopentanone 1,2-monooxygenase activity"], "types": ["T044"], "canonical_name": "cyclopentanone monooxygenase activity", "definition": "Catalysis of the reaction: cyclopentanone + H(+) + NADPH + O(2) = 5-valerolactone + H(2)O + NADP(+). [EC:1.14.13.16, RHEA:15737]"}
{"concept_id": "C1324339", "aliases": ["dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)", "dihydrochelirubine 12-hydroxylase activity"], "types": ["T044"], "canonical_name": "dihydrochelirubine 12-monooxygenase activity", "definition": "Catalysis of the reaction: dihydrochelirubine + H(+) + NADPH + O(2) = 12-hydroxydihydrochelirubine + H(2)O + NADP(+). [EC:1.14.14.101, RHEA:10156]"}
{"concept_id": "C1324340", "aliases": ["dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)", "dihydrosanguinarine 10-hydroxylase activity"], "types": ["T044"], "canonical_name": "dihydrosanguinarine 10-monooxygenase activity", "definition": "Catalysis of the reaction: dihydrosanguinarine + H(+) + NADPH + O(2) = 10-hydroxydihydrosanguinarine + H(2)O + NADP(+). [EC:1.14.14.100, RHEA:10528]"}
{"concept_id": "C1324341", "aliases": ["4-hydroxyphenylacetonitrile hydroxylase activity", "4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)", "4-hydroxyphenylacetonitrile monooxygenase activity"], "types": ["T044"], "canonical_name": "hydroxyphenylacetonitrile 2-monooxygenase activity", "definition": "Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H(+) + NADPH + O(2) = 4-hydroxymandelonitrile + H(2)O + NADP(+). [RHEA:50732]"}
{"concept_id": "C1324342", "aliases": ["imidazoleacetate hydroxylase activity", "imidazoleacetic hydroxylase activity", "4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)", "imidazoleacetic monooxygenase activity"], "types": ["T044"], "canonical_name": "imidazoleacetate 4-monooxygenase activity", "definition": "Catalysis of the reaction: H(+) + imidazol-4-ylacetate + NADH + O(2) = 5-hydroxyimidazole-4-acetate + H(2)O + NAD(+). [EC:1.14.13.5, RHEA:19425]"}
{"concept_id": "C1324343", "aliases": [], "types": ["T044"], "canonical_name": "isoflavone 2'-hydroxylase activity", "definition": "Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [RHEA:18849]"}
{"concept_id": "C1324344", "aliases": ["isoflavone 3'-monooxygenase activity", "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)"], "types": ["T044"], "canonical_name": "isoflavone 3'-hydroxylase activity", "definition": "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O. [EC:1.14.14.88, MetaCyc:ISOFLAVONE-3'-HYDROXYLASE-RXN]"}
{"concept_id": "C1324345", "aliases": ["steroid-ketone monooxygenase activity", "progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)", "androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)", "17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)", "ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)"], "types": ["T044"], "canonical_name": "ketosteroid monooxygenase activity", "definition": "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN]"}
{"concept_id": "C1324346", "aliases": ["leukotriene-B4 20-hydroxylase activity", "LTB(4) 20-hydroxylase activity", "LTB(4) omega-hydroxylase activity", "LTB4 omega-hydroxylase activity", "LTB4 20-hydroxylase activity", "leukotriene-B4 omega-hydroxylase activity"], "types": ["T044"], "canonical_name": "leukotriene-B4 20-monooxygenase activity", "definition": "Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [PMID:11461919, PMID:15364545, PMID:8486631, PMID:9675028, RHEA:22176]"}
{"concept_id": "C1324347", "aliases": ["leukotriene-E(4) omega-hydroxylase activity", "leukotriene-E4 w-hydroxylase activity", "(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)", "leukotriene-E4 omega-hydroxylase activity"], "types": ["T044"], "canonical_name": "leukotriene-E4 20-monooxygenase activity", "definition": "Catalysis of the reaction: H(+) + leukotriene E(4) + NADPH + O(2) = 20-hydroxy-leukotriene E(4) + H(2)O + NADP(+). [EC:1.14.13.34, RHEA:24120]"}
{"concept_id": "C1324348", "aliases": ["melilotic hydroxylase activity", "3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)", "2-hydroxyphenylpropionic hydroxylase activity", "2-hydroxyphenylpropionate hydroxylase activity", "melilotate hydroxylase activity"], "types": ["T044"], "canonical_name": "melilotate 3-monooxygenase activity", "definition": "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+). [EC:1.14.13.4, RHEA:17669]"}
{"concept_id": "C1324349", "aliases": ["methyltetrahydroprotoberberine 14-hydroxylase activity", "(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)", "(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity", "(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity"], "types": ["T044"], "canonical_name": "methyltetrahydroprotoberberine 14-monooxygenase activity", "definition": "Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine. [EC:1.14.14.97, MetaCyc:1.14.13.37-RXN]"}
{"concept_id": "C1324350", "aliases": ["cytochrome P450 80B1 activity", "(S)-N-methylcoclaurine 3'-hydroxylase activity", "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)", "N-methylcoclaurine 3'-hydroxylase activity"], "types": ["T044"], "canonical_name": "N-methylcoclaurine 3'-monooxygenase activity", "definition": "Catalysis of the reaction: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+). [EC:1.14.14.102, RHEA:16649]"}
{"concept_id": "C1324351", "aliases": ["oleate delta12-hydroxylase activity", "oleate D12-hydroxylase activity", "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)", "ricinoleic acid synthase activity", "oleate delta12-monooxygenase activity", "oleate Delta(12)-hydroxylase activity"], "types": ["T044"], "canonical_name": "phosphatidylcholine 12-monooxygenase activity", "definition": "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O(2) = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H(2)O + NAD(+). [RHEA:46360]"}
{"concept_id": "C1324352", "aliases": ["protopine 6-hydroxylase activity", "protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)"], "types": ["T044"], "canonical_name": "protopine 6-monooxygenase activity", "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + protopine = 6-hydroxyprotopine + H(2)O + NADP(+). [EC:1.14.14.98, RHEA:22644]"}
{"concept_id": "C1324353", "aliases": ["questin oxygenase activity", "questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)"], "types": ["T044"], "canonical_name": "questin monooxygenase activity", "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + questin = demethylsulochrin + NADP(+). [EC:1.14.13.43, RHEA:10836]"}
{"concept_id": "C1324354", "aliases": ["quinine,NADPH:oxygen oxidoreductase activity", "quinine 3-hydroxylase activity", "nifedipine oxidase activity"], "types": ["T044"], "canonical_name": "quinine 3-monooxygenase activity", "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). [EC:1.14.14.55, RHEA:20149]"}
{"concept_id": "C1324355", "aliases": ["sterol 14-alpha-demethylase activity", "sterol 14-demethylase activity", "lanosterol 14alpha-demethylase activity", "sterol 14alpha-demethylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]. [RHEA:54028]", "canonical_name": "lanosterol 14-alpha-demethylase activity"}
{"concept_id": "C1324356", "aliases": ["tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)"], "types": ["T044"], "canonical_name": "tabersonine 16-hydroxylase activity", "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+). [EC:1.14.14.103, RHEA:14133]"}
{"concept_id": "C1324357", "aliases": ["taxane 10b-hydroxylase activity", "5-alpha-taxadienol-10-beta-hydroxylase activity", "taxane 10beta-hydroxylase activity", "taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)"], "types": ["T044"], "canonical_name": "taxane 10-beta-hydroxylase activity", "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+). [EC:1.14.14.105, RHEA:15241]"}
{"concept_id": "C1324358", "aliases": ["taxane 13alpha-hydroxylase activity", "taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)", "taxane 13a-hydroxylase activity"], "types": ["T044"], "canonical_name": "taxane 13-alpha-hydroxylase activity", "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol. [EC:1.14.14.106, RHEA:18949]"}
{"concept_id": "C1324359", "aliases": ["taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)", "taxifolin hydroxylase activity"], "types": ["T044"], "canonical_name": "taxifolin 8-monooxygenase activity", "definition": "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O. [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN]"}
{"concept_id": "C1324360", "aliases": ["cinnamate 2-monooxygenase activity", "cinnamate 2-hydroxylase activity", "cinnamic acid 2-hydroxylase activity", "cinnamic 2-hydroxylase activity", "trans-cinnamic acid 2-hydroxylase activity", "trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)"], "types": ["T044"], "canonical_name": "trans-cinnamate 2-monooxygenase activity", "definition": "Catalysis of the reaction: trans-cinnamate + H(+) + NADPH + O(2) = 2-coumarate + H(2)O + NADP(+). [EC:1.14.13.14, RHEA:10956]"}
{"concept_id": "C1324361", "aliases": ["tyrosine N-hydroxylase activity", "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)"], "types": ["T044"], "canonical_name": "tyrosine N-monooxygenase activity", "definition": "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O. [MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN]"}
{"concept_id": "C1324362", "aliases": ["vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)"], "types": ["T044"], "canonical_name": "vinorine hydroxylase activity", "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + vinorine = H(2)O + NADP(+) + vomilenine. [EC:1.14.14.104, RHEA:17257]"}
{"concept_id": "C1324363", "aliases": ["2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity", "3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)", "methylhydroxypyridine carboxylate dioxygenase activity", "3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity", "methylhydroxypyridinecarboxylate oxidase activity"], "types": ["T044"], "canonical_name": "3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity", "definition": "Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate. [EC:1.14.13.242, MetaCyc:1.14.12.4-RXN]"}
{"concept_id": "C1324364", "aliases": ["5-pyridoxate oxidase activity"], "types": ["T044"], "canonical_name": "5-pyridoxate dioxygenase activity", "definition": "Catalysis of the reaction: 5-pyridoxate + NADPH + O(2) = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate) + NADP(+). [RHEA:11152]"}
{"concept_id": "C1324365", "aliases": ["vibrio fischeri luciferase activity", "alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)", "bacterial luciferase activity"], "types": ["T044"], "canonical_name": "alkanal monooxygenase (FMN-linked) activity", "definition": "Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light. [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN]"}
{"concept_id": "C1324366", "aliases": [], "types": ["T044"], "canonical_name": "unspecific monooxygenase activity"}
{"concept_id": "C1324367", "aliases": ["corticosterone 18-hydroxylase activity", "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)"], "types": ["T044"], "canonical_name": "corticosterone 18-monooxygenase activity", "definition": "Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O. [EC:1.14.15.5, MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN]"}
{"concept_id": "C1324369", "aliases": ["glyceryl ether oxygenase activity", "O-alkylglycerol monooxygenase activity", "alkylglycerol monooxygenase activity", "1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity", "glyceryl-ether cleaving enzyme activity", "glyceryl etherase activity"], "types": ["T044"], "canonical_name": "glyceryl-ether monooxygenase activity", "definition": "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine). [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN]"}
{"concept_id": "C1324370", "aliases": ["mandelic acid 4-hydroxylase activity", "(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)", "L-mandelate 4-hydroxylase activity"], "types": ["T044"], "canonical_name": "mandelate 4-monooxygenase activity", "definition": "Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O(2) = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H(2)O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate. [EC:1.14.16.6, RHEA:21716]"}
{"concept_id": "C1324371", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated. [GOC:mah]"}
{"concept_id": "C1324374", "aliases": ["(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity", "(S)-tetrahydroberberine synthase activity"], "types": ["T044"], "canonical_name": "(S)-canadine synthase activity", "definition": "Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:21456]"}
{"concept_id": "C1324375", "aliases": ["(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)", "(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity"], "types": ["T044"], "canonical_name": "(S)-cheilanthifoline synthase activity", "definition": "Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:20485]"}
{"concept_id": "C1324376", "aliases": ["(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)", "(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity"], "types": ["T044"], "canonical_name": "(S)-stylopine synthase activity", "definition": "Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:13773]"}
{"concept_id": "C1324377", "aliases": [], "types": ["T044"], "canonical_name": "berbamunine synthase activity", "definition": "Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 <=> berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:23576]"}
{"concept_id": "C1324378", "aliases": ["(R)-reticuline oxidase (C-C phenol-coupling) activity"], "types": ["T044"], "canonical_name": "salutaridine synthase activity", "definition": "Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [RHEA:17713]"}
{"concept_id": "C1324380", "aliases": ["triphosphopyridine nucleotide peroxidase activity", "NADPH:hydrogen-peroxide oxidoreductase activity", "nicotinamide adenine dinucleotide phosphate peroxidase activity", "TPN peroxidase activity", "NADP peroxidase activity", "TPNH peroxidase activity"], "types": ["T044"], "canonical_name": "NADPH peroxidase activity", "definition": "Catalysis of the reaction: H(2)O(2) + H(+) + NADPH = 2 H(2)O + NADP(+). [EC:1.11.1.2, RHEA:15173]"}
{"concept_id": "C1324381", "aliases": ["glutathione:lipid-hydroperoxide oxidoreductase activity", "peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)", "PHGPX", "phospholipid-hydroperoxide glutathione peroxidase activity", "hydroperoxide glutathione peroxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione. [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN]", "canonical_name": "phospholipid hydroperoxide glutathione peroxidase activity"}
{"concept_id": "C1324382", "aliases": ["glutathione:methylarsonate oxidoreductase activity", "MMA(V) reductase activity"], "types": ["T044"], "canonical_name": "methylarsonate reductase activity", "definition": "Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid. [EC:1.20.4.2, RHEA:15969]"}
{"concept_id": "C1324383", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H. [GOC:mah]"}
{"concept_id": "C1324384", "aliases": ["phosphonate:NAD+ oxidoreductase activity", "NAD:phosphite oxidoreductase activity", "phosphite dehydrogenase activity", "NAD-dependent phosphite dehydrogenas activity"], "types": ["T044"], "canonical_name": "phosphonate dehydrogenase activity", "definition": "Catalysis of the reaction: H(2)O + NAD(+) + phosphonate = 2 H(+) + NADH + phosphate. [EC:1.20.1.1, RHEA:13173]"}
{"concept_id": "C1324385", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP. [GOC:ai]"}
{"concept_id": "C1324386", "aliases": ["arsenate:(acceptor) oxidoreductase activity", "arsenate:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "arsenate reductase (donor) activity", "definition": "Catalysis of the reaction: A + arsenite + H(2)O = AH(2) + arsenate + 2 H(+). [EC:1.20.99.1, RHEA:18449]"}
{"concept_id": "C1324387", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP. [GOC:ai]"}
{"concept_id": "C1324389", "aliases": ["reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)"], "types": ["T044"], "canonical_name": "nitrogenase (flavodoxin) activity", "definition": "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate. [EC:1.19.6.1, MetaCyc:NITROGENASE-FLAVODOXIN-RXN]"}
{"concept_id": "C1324390", "aliases": ["8'-apo-beta-carotenol:O2 oxidoreductase activity", "apo-b-carotenoid-14',13'-dioxygenase activity"], "types": ["T044"], "canonical_name": "apo-beta-carotenoid-14',13'-dioxygenase activity", "definition": "Catalysis of the reaction: 8'-apo-beta-carotenol + O(2) = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal. [EC:1.13.11.67, RHEA:26023]"}
{"concept_id": "C1324391", "aliases": ["arginine monooxygenase activity", "arginine oxygenase (decarboxylating) activity", "arginine decarboxy-oxidase activity", "L-arginine:oxygen 2-oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "arginine 2-monooxygenase activity", "definition": "Catalysis of the reaction: L-arginine + O(2) = 4-guanidinobutanamide + CO(2) + H(2)O. [EC:1.13.12.1, RHEA:10548]"}
{"concept_id": "C1324392", "aliases": ["Cypridina luciferase activity", "Cypridina-type luciferase activity", "Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)", "luciferase (Cypridina luciferin)"], "types": ["T044"], "canonical_name": "Cypridina-luciferin 2-monooxygenase activity", "definition": "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light. [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN]"}
{"concept_id": "C1324393", "aliases": ["lactate oxygenase activity", "lactate oxidase activity", "(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)", "lactic oxidase activity", "lactate monooxygenase activity", "lactate oxidative decarboxylase activity", "L-lactate monooxygenase activity", "lactic oxygenase activity", "L-lactate-2-monooxygenase activity"], "types": ["T044"], "canonical_name": "lactate 2-monooxygenase activity", "definition": "Catalysis of the reaction: (S)-lactate + O(2) = acetate + CO(2) + H(2)O. [EC:1.13.12.4, RHEA:16513]"}
{"concept_id": "C1324394", "aliases": ["lysine monooxygenase activity", "L-lysine-2-monooxygenase activity", "L-lysine:oxygen 2-oxidoreductase (decarboxylating)", "lysine oxygenase activity"], "types": ["T044"], "canonical_name": "lysine 2-monooxygenase activity", "definition": "Catalysis of the reaction: L-lysine + O(2) = 5-aminopentanamide + CO(2) + H(2)O. [EC:1.13.12.2, RHEA:14601]"}
{"concept_id": "C1324396", "aliases": ["L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)", "phenylalanine (deaminating, decarboxylating)oxidase activity", "phenylalanine (deaminating, decarboxylating) oxidase activity", "L-phenylalanine oxidase (deaminating and decarboxylating)", "l-phenylalanine oxidase (deaminating and decarboxylating) activity"], "types": ["T044"], "canonical_name": "phenylalanine 2-monooxygenase activity", "definition": "Catalysis of the reaction: L-phenylalanine + O(2) = 2-phenylacetamide + CO(2) + H(2)O. [EC:1.13.12.9, RHEA:10712]"}
{"concept_id": "C1324397", "aliases": ["firefly luciferin luciferase activity", "Photinus pyralis luciferase activity", "Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity", "Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)", "firefly luciferase activity", "luciferase (firefly luciferin)", "Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)"], "types": ["T044"], "definition": "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin. [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN]", "canonical_name": "Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)"}
{"concept_id": "C1324398", "aliases": ["luciferase (Renilla luciferin)", "Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)", "Renilla-type luciferase activity"], "types": ["T044"], "canonical_name": "Renilla-luciferin 2-monooxygenase activity", "definition": "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light. [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN]"}
{"concept_id": "C1324399", "aliases": ["L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "tryptophan 2-monooxygenase activity", "definition": "Catalysis of the reaction: L-tryptophan + O(2) = CO(2) + H(2)O + indole-3-acetamide. [EC:1.13.12.3, RHEA:16165]"}
{"concept_id": "C1324400", "aliases": ["Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)", "Watasenia-type luciferase activity"], "types": ["T044"], "canonical_name": "Watasenia-luciferin 2-monooxygenase activity", "definition": "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light. [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN]"}
{"concept_id": "C1324401", "aliases": ["2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)", "2,3-dihydroxybenzoate 2,3-oxygenase activity"], "types": ["T044"], "canonical_name": "2,3-dihydroxybenzoate 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-carboxy-cis,cis-muconate + 2 H(+). [EC:1.13.11.28, RHEA:15369]"}
{"concept_id": "C1324402", "aliases": ["2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity"], "types": ["T044"], "canonical_name": "2,3-dihydroxyindole 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: 2,3-dihydroxyindole + O(2) = anthranilate + CO(2) + H(+). [EC:1.13.11.23, RHEA:19445]"}
{"concept_id": "C1324403", "aliases": ["(4-hydroxybenzoyl)methanol oxygenase activity", "2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)"], "types": ["T044"], "canonical_name": "2,4'-dihydroxyacetophenone dioxygenase activity", "definition": "Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O(2) = 4-hydroxybenzoate + formate + 2 H(+). [EC:1.13.11.41, RHEA:24416]"}
{"concept_id": "C1324404", "aliases": ["pyridine-2,5-diol dioxygenase activity", "2,5-dihydroxypyridine oxygenase activity", "2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2,5-dihydroxypyridine 5,6-dioxygenase activity", "definition": "Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate. [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN]"}
{"concept_id": "C1324405", "aliases": ["3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)", "3-alkylcatechol 2,3-dioxygenase activity"], "types": ["T044"], "canonical_name": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+). [EC:1.13.11.25, RHEA:21352]"}
{"concept_id": "C1324406", "aliases": ["3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)", "2,3-dihydroxy-beta-phenylpropionic dioxygenase activity", "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity", "2,3-dihydroxy-beta-phenylpropionate oxygenase activity"], "types": ["T044"], "canonical_name": "3-carboxyethylcatechol 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN]"}
{"concept_id": "C1324407", "aliases": ["1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity", "(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity", "1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity", "3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity", "3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)"], "types": ["T044"], "canonical_name": "3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity", "definition": "Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H(+) + O(2) = N-acetylanthranilate + CO. [EC:1.13.11.48, RHEA:21572]"}
{"concept_id": "C1324408", "aliases": ["3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity", "1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity", "3-hydroxy-4(1H)-one, 2,4-dioxygenase activity", "(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity", "3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)", "quinoline-3,4-diol 2,4-dioxygenase activity"], "types": ["T044"], "canonical_name": "3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity", "definition": "Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate. [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN]"}
{"concept_id": "C1324409", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxycatechol 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate. [RHEA:35595]"}
{"concept_id": "C1324410", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxymandelate synthase activity", "definition": "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2. [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN]"}
{"concept_id": "C1324411", "aliases": ["7,8-dihydroxykynurenate oxygenase activity", "7,8-dihydroxykynurenate:oxygen 8,8alpha-oxidoreductase (decyclizing)", "7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)", "7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity"], "types": ["T044"], "canonical_name": "7,8-dihydroxykynurenate 8,8a-dioxygenase activity", "definition": "Catalysis of the reaction: 7,8-dihydroxykynurenate + O(2) = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+). [EC:1.13.11.10, RHEA:23400]"}
{"concept_id": "C1324412", "aliases": ["arachidonate omega6 lipoxygenase activity", "arachidonate:oxygen 15-oxidoreductase activity", "linoleic acid omega6-lipoxygenase activity", "15-lipoxygenase activity", "arachidonate omega(6) lipoxygenase activity", "omega6 lipoxygenase activity"], "types": ["T044"], "canonical_name": "arachidonate 15-lipoxygenase activity", "definition": "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. [EC:1.13.11.33]"}
{"concept_id": "C1324413", "aliases": ["arachidonate 8-lipoxygenase activity", "arachidonate:oxygen 8-oxidoreductase activity", "8(R)-lipoxygenase activity"], "types": ["T044"], "canonical_name": "arachidonate 8(R)-lipoxygenase activity", "definition": "Catalysis of the reaction: arachidonate + O(2) = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. [EC:1.13.11.40, RHEA:14985]"}
{"concept_id": "C1324415", "aliases": ["3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)"], "types": ["T044"], "canonical_name": "caffeate 3,4-dioxygenase activity", "definition": "Catalysis of the reaction: trans-caffeate + O(2) = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+). [EC:1.13.11.22, RHEA:22216]"}
{"concept_id": "C1324416", "aliases": ["5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)"], "types": ["T044"], "canonical_name": "chloridazon-catechol dioxygenase activity", "definition": "Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O(2) = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+). [EC:1.13.11.36, RHEA:20449]"}
{"concept_id": "C1324418", "aliases": ["cysteamine:oxygen oxidoreductase activity", "2-aminoethanethiol:oxygen oxidoreductase activity", "cysteamine oxygenase activity"], "types": ["T044"], "canonical_name": "cysteamine dioxygenase activity", "definition": "Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine. [EC:1.13.11.19, RHEA:14409]"}
{"concept_id": "C1324419", "aliases": [], "types": ["T044"], "canonical_name": "1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity", "definition": "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid. [UM-BBD_reactionID:r0422]"}
{"concept_id": "C1324420", "aliases": [], "types": ["T044"], "canonical_name": "3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid. [UM-BBD_reactionID:r0415]"}
{"concept_id": "C1324421", "aliases": ["gentisate oxygenase activity", "gentisic acid oxidase activity", "gentisate dioxygenase activity", "2,5-dihydroxybenzoate dioxygenase activity", "gentisate:oxygen 1,2-oxidoreductase (decyclizing)"], "types": ["T044"], "canonical_name": "gentisate 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: 2,5-dihydroxybenzoate + O(2) = 3-maleylpyruvate + H(+). [EC:1.13.11.4, RHEA:18237]"}
{"concept_id": "C1324422", "aliases": ["indole-oxygen 2,3-oxidoreductase (decyclizing)", "indole:oxygen 2,3-oxidoreductase (decyclizing)", "IDO", "indole oxidase activity", "indole:O2 oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: indole + O(2) = 2-formamidobenzaldehyde. [EC:1.13.11.17, RHEA:11212]", "canonical_name": "indole 2,3-dioxygenase activity"}
{"concept_id": "C1324423", "aliases": ["lignostilbene ab-dioxygenase activity", "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)", "lignostilbene alphabeta-dioxygenase activity"], "types": ["T044"], "canonical_name": "lignostilbene alpha beta-dioxygenase activity", "definition": "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin. [EC:1.13.11.43, RHEA:21340]"}
{"concept_id": "C1324424", "aliases": ["linoleate:oxygen 11S-oxidoreductase activity", "linoleate dioxygenase activity", "manganese lipoxygenase activity"], "types": ["T044"], "canonical_name": "linoleate 11-lipoxygenase activity", "definition": "Catalysis of the reaction: linoleate + O(2) = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate. [EC:1.13.11.45, RHEA:18993]"}
{"concept_id": "C1324425", "aliases": ["peptidyltryptophan 2,3-dioxygenase activity", "tryptophan pyrrolooxygenase activity", "peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)", "pyrrolooxygenase activity"], "types": ["T044"], "canonical_name": "peptide-tryptophan 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine. [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN, PMID:4403729]"}
{"concept_id": "C1324426", "aliases": ["1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)", "pyrogallol 1,2-dioxygenase activity"], "types": ["T044"], "canonical_name": "pyrogallol 1,2-oxygenase activity", "definition": "Catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+). [EC:1.13.11.35, RHEA:19673]"}
{"concept_id": "C1324427", "aliases": ["3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)"], "types": ["T044"], "canonical_name": "stizolobate synthase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN]"}
{"concept_id": "C1324428", "aliases": ["3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)"], "types": ["T044"], "canonical_name": "stizolobinate synthase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN]"}
{"concept_id": "C1324429", "aliases": ["sulphur dioxygenase activity", "S-sulfanylglutathione:oxygen oxidoreductase activity", "sulfur:oxygen oxidoreductase activity", "sulfur oxygenase activity"], "types": ["T044"], "canonical_name": "sulfur dioxygenase activity", "definition": "Catalysis of the reaction: sulfur + O2 + H2O = sulfite. [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN]"}
{"concept_id": "C1324430", "aliases": ["myo-inositol oxygenase activity", "meso-inositol oxygenase activity", "MOO activity", "myo-inositol:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "inositol oxygenase activity", "definition": "Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+). [RHEA:23696]"}
{"concept_id": "C1324431", "aliases": ["L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)", "tryptophan side chain oxidase II", "TSO activity", "tryptophan side-chain alpha,beta-oxidase activity", "indolyl-3-alkan alpha-hydroxylase activity", "tryptophan side-chain oxidase activity", "tryptophan side chain oxidase activity", "TSO II", "TSO I", "tryptophan side chain oxidase type I", "indole-3-alkane alpha-hydroxylase activity"], "types": ["T044"], "canonical_name": "tryptophan 2'-dioxygenase activity", "definition": "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3. [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN]"}
{"concept_id": "C1324432", "aliases": ["sulfite cytochrome c reductase activity", "sulfite-cytochrome c oxidoreductase activity", "sulphite dehydrogenase activity", "sulfite:ferricytochrome-c oxidoreductase activity"], "types": ["T044"], "canonical_name": "sulfite dehydrogenase activity", "definition": "Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c. [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324433", "aliases": ["thiosulfate-acceptor oxidoreductase activity", "thiosulfate oxidase activity", "thiosulfate:ferricytochrome-c oxidoreductase activity", "tetrathionate synthase activity", "thiosulphate dehydrogenase activity"], "types": ["T044"], "canonical_name": "thiosulfate dehydrogenase activity", "definition": "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c. [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324434", "aliases": ["thiol:disulfide oxidoreductase activity", "glutathione-dependent thiol:disulfide oxidoreductase activity", "xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity", "thiol:disulphide oxidoreductase activity", "enzyme-thiol transhydrogenase (oxidized-glutathione) activity", "enzyme-thiol transhydrogenase (glutathione-disulphide) activity", "xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity", "[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity"], "types": ["T044"], "canonical_name": "enzyme-thiol transhydrogenase (glutathione-disulfide) activity", "definition": "Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase. [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN]"}
{"concept_id": "C1324435", "aliases": ["glutathione:coenzyme A-glutathione transhydrogenase activity", "CoA:glutathione-disulfide oxidoreductase activity", "glutathione coenzyme A-glutathione transhydrogenase activity", "coenzyme A:glutathione-disulfide oxidoreductase activity", "glutathione-coenzyme A glutathione disulfide transhydrogenase activity", "coenzyme A:oxidized-glutathione oxidoreductase activity"], "types": ["T044"], "canonical_name": "glutathione-CoA-glutathione transhydrogenase activity", "definition": "Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione. [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN]"}
{"concept_id": "C1324436", "aliases": ["GSH-cystine transhydrogenase", "NADPH-dependent GSH-cystine transhydrogenase", "glutathione:cystine oxidoreductase"], "types": ["T044"], "canonical_name": "glutathione-cystine transhydrogenase activity", "definition": "Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine. [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN]"}
{"concept_id": "C1324437", "aliases": ["glutathione:homocystine oxidoreductase activity"], "types": ["T044"], "canonical_name": "glutathione-homocystine transhydrogenase activity", "definition": "Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine. [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN]"}
{"concept_id": "C1324438", "aliases": ["hydrogen-sulfide:ferredoxin oxidoreductase activity", "ferredoxin-sulfite reductase activity", "sulphite reductase (ferredoxin) activity"], "types": ["T044"], "canonical_name": "sulfite reductase (ferredoxin) activity", "definition": "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin. [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN]"}
{"concept_id": "C1324439", "aliases": ["NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity", "NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity", "2-KPCC activity", "2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "2-oxopropyl-CoM reductase (carboxylating) activity", "definition": "Catalysis of the reaction: acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO(2) + NADPH. [EC:1.8.1.5, RHEA:16977]"}
{"concept_id": "C1324440", "aliases": ["3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity", "asparagusate reductase (NADH2)", "asparagusate reductase (NADH) activity", "asparagusate dehydrogenase activity", "NADH2:asparagusate oxidoreductase activity", "NADH:asparagusate oxidoreductase activity", "asparagusic dehydrogenase activity"], "types": ["T044"], "canonical_name": "asparagusate reductase activity", "definition": "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD(+) = asparagusate + H(+) + NADH. [RHEA:14881]"}
{"concept_id": "C1324442", "aliases": ["NADH2:CoA-disulfide oxidoreductase activity", "CoA-disulfide reductase (NADH2)", "CoA-disulfide reductase (NADH) activity", "NADH:CoA-disulfide oxidoreductase activity", "CoA:NAD+ oxidoreductase activity", "CoA:NAD(P)+ oxidoreductase activity", "CoA-disulphide reductase activity", "coenzyme A disulfide reductase activity", "CoADR activity"], "types": ["T044"], "canonical_name": "CoA-disulfide reductase activity", "definition": "Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+. [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN]"}
{"concept_id": "C1324443", "aliases": ["coenzyme A glutathione disulfide reductase activity", "glutathione:NADP+ oxidoreductase (CoA-acylating)", "NADPH-dependent coenzyme A-SS-glutathione reductase activity", "NADPH2:CoA-glutathione oxidoreductase activity", "CoA-glutathione reductase (NADPH) activity", "coenzyme A disulfide-glutathione reductase activity", "NADPH:CoA-glutathione oxidoreductase activity"], "types": ["T044"], "canonical_name": "CoA-glutathione reductase activity", "definition": "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+. [RHEA:14617]"}
{"concept_id": "C1324444", "aliases": ["NADH2:L-cystine oxidoreductase", "cystine reductase (NADH) activity", "L-cysteine:NAD+ oxidoreductase", "cystine reductase (NADH2)", "NADH-dependent cystine reductase activity", "NADH:L-cystine oxidoreductase activity"], "types": ["T044"], "canonical_name": "cystine reductase activity", "definition": "Catalysis of the reaction: 2 L-cysteine + NAD(+) = L-cystine + H(+) + NADH. [EC:1.8.1.6, RHEA:20597]"}
{"concept_id": "C1324445", "aliases": ["hypotaurine:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "hypotaurine dehydrogenase activity", "definition": "Catalysis of the reaction: H(2)O + hypotaurine + NAD(+) = H(+) + NADH + taurine. [RHEA:17385]"}
{"concept_id": "C1324446", "aliases": ["mycothiol-disulfide reductase activity", "mycothiol:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "mycothione reductase activity", "definition": "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione. [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN]"}
{"concept_id": "C1324448", "aliases": ["APS reductase activity", "adenylyl-sulphate reductase activity", "adenosine 5'-phosphosulfate reductase", "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)", "APS-reductase", "adenosine phosphosulfate reductase activity", "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)"], "types": ["T044"], "canonical_name": "adenylyl-sulfate reductase activity", "definition": "Catalysis of the reaction: AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor. [EC:1.8.99.2, PMID:5421934]"}
{"concept_id": "C1324449", "aliases": ["glutathione:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "glutathione oxidase activity", "definition": "Catalysis of the reaction: 2 glutathione + O(2) = glutathione disulfide + H(2)O(2). [EC:1.8.3.3, RHEA:24112]"}
{"concept_id": "C1324450", "aliases": ["S-prenyl-L-cysteine:oxygen oxidoreductase activity", "prenylcysteine oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2. [GOC:hjd, RHEA:53892]", "canonical_name": "prenylcysteine lyase activity"}
{"concept_id": "C1324451", "aliases": ["rubredoxin:superoxide oxidoreductase activity"], "types": ["T044"], "canonical_name": "superoxide reductase activity", "definition": "Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin. [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN]"}
{"concept_id": "C1324452", "aliases": ["formate:ferricytochrome-b1 oxidoreductase activity", "formate:cytochrome b1 oxidoreductase activity"], "types": ["T044"], "canonical_name": "formate dehydrogenase (cytochrome) activity", "definition": "Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1. [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN]"}
{"concept_id": "C1324453", "aliases": ["formate dehydrogenase (cytochrome c-553)", "formate:ferricytochrome-c-553 oxidoreductase activity"], "types": ["T044"], "canonical_name": "formate dehydrogenase (cytochrome-c-553) activity", "definition": "Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2. [EC:1.17.2.3, MetaCyc:1.2.2.3-RXN]"}
{"concept_id": "C1324454", "aliases": ["2-ketoglutarate ferredoxin oxidoreductase activity", "KGOR activity", "2-oxoglutarate ferredoxin oxidoreductase activity", "alpha-ketoglutarate-ferredoxin oxidoreductase activity", "2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)", "alpha-ketoglutarate synthase activity", "2-oxoglutarate:ferredoxin oxidoreductase activity", "2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "2-oxoglutarate synthase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin. [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN]"}
{"concept_id": "C1324455", "aliases": ["D-aldopantoate dehydrogenase activity", "D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity", "(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity"], "types": ["T044"], "canonical_name": "(R)-dehydropantoate dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-4-dehydropantoate + H(2)O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH. [EC:1.2.1.33, RHEA:19349]"}
{"concept_id": "C1324457", "aliases": ["2-oxoaldehyde:NAD+ 2-oxidoreductase activity", "NAD-dependent alpha-ketoaldehyde dehydrogenase activity", "2-oxoaldehyde dehydrogenase (NAD+) activity", "NAD-linked alpha-ketoaldehyde dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+. [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN]", "canonical_name": "2-oxoaldehyde dehydrogenase (NAD+)"}
{"concept_id": "C1324458", "aliases": ["NADP-linked alpha-ketoaldehyde dehydrogenase activity", "NADP-dependent alpha-ketoaldehyde dehydrogenase activity", "2-oxoaldehyde:NADP+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-oxoaldehyde dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+. [EC:1.2.1.49, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN]"}
{"concept_id": "C1324459", "aliases": ["2-oxoisovalerate dehydrogenase activity", "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)"], "types": ["T044"], "canonical_name": "2-oxoisovalerate dehydrogenase (acylating) activity", "definition": "Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA. [EC:1.2.1.25, MetaCyc:1.2.1.25-RXN]"}
{"concept_id": "C1324460", "aliases": ["THAL-NAD oxidoreductase activity", "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity", "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity", "cholestanetriol-26-al 26-dehydrogenase activity", "trihydroxydeoxycoprostanal dehydrogenase activity", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity", "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity"], "types": ["T044"], "canonical_name": "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity", "definition": "Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate. [PMID:8496170, RHEA:34627]"}
{"concept_id": "C1324462", "aliases": ["4-HPAL dehydrogenase activity", "4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate. [EC:1.2.1.53, MetaCyc:1.2.1.53-RXN]"}
{"concept_id": "C1324463", "aliases": ["4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity", "4-trimethylaminobutyraldehyde dehydrogenase activity", "4-N-trimethylaminobutyraldehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "4-trimethylammoniobutyraldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate. [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN]"}
{"concept_id": "C1324464", "aliases": ["2-hydroxymuconic semialdehyde dehydrogenase activity", "2-aminomuconate semialdehyde dehydrogenase activity", "2-hydroxymuconate semialdehyde dehydrogenase activity", "alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity", "2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity", "2-hydroxymuconic acid semialdehyde dehydrogenase activity", "alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "aminomuconate-semialdehyde dehydrogenase activity", "definition": "Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate. [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN]"}
{"concept_id": "C1324465", "aliases": ["aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)", "aromatic acid reductase activity"], "types": ["T044"], "canonical_name": "aryl-aldehyde dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP. [EC:1.2.1.30, MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN]"}
{"concept_id": "C1324466", "aliases": ["butanal:NAD(P)+ oxidoreductase (CoA-acylating)"], "types": ["T044"], "canonical_name": "butanal dehydrogenase activity", "definition": "Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+. [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324467", "aliases": ["coniferyl aldehyde:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "coniferyl-aldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+. [EC:1.2.1.68, MetaCyc:RXN-1241]"}
{"concept_id": "C1324468", "aliases": ["NADP-dependent formate dehydrogenase activity", "formate:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "formate dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: formate + NADP(+) = CO(2) + NADPH. [EC:1.17.1.10, RHEA:12000]"}
{"concept_id": "C1324469", "aliases": ["4-guanidinobutanal:NAD+ 1-oxidoreductase activity", "GBAL dehydrogenase activity", "alpha-guanidinobutyraldehyde dehydrogenase activity", "4-guanidinobutyraldehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "gamma-guanidinobutyraldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 4-guanidinobutanal + H(2)O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH. [EC:1.2.1.54, RHEA:14381]"}
{"concept_id": "C1324470", "aliases": ["glutarate semialdehyde dehydrogenase (NAD+) activity", "glutarate-semialdehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "glutarate-semialdehyde dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH. [EC:1.2.1.20, MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324471", "aliases": ["NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity", "triosephosphate dehydrogenase (NADP+) activity", "triosephosphate dehydrogenase (NADP)", "triosephosphate dehydrogenase (NADP(+)) activity", "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)", "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)", "NADP-dependent glyceraldehyde phosphate dehydrogenase activity", "glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)", "NADP-triose phosphate dehydrogenase activity"], "types": ["T044"], "canonical_name": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity", "definition": "Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate. [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN]"}
{"concept_id": "C1324472", "aliases": ["glycolaldehyde:NAD+ oxidoreductase activity", "glycol aldehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "glycolaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: glycolaldehyde + H(2)O + NAD(+) = glycolate + 2 H(+) + NADH. [EC:1.2.1.21, RHEA:20001]"}
{"concept_id": "C1324474", "aliases": ["hexadecanal:NAD+ oxidoreductase (CoA-acylating)"], "types": ["T044"], "canonical_name": "hexadecanal dehydrogenase (acylating) activity", "definition": "Catalysis of the reaction: CoA + NAD(+) + palmitaldehyde = H(+) + NADH + palmitoyl-CoA. [EC:1.2.1.42, RHEA:19705]"}
{"concept_id": "C1324475", "aliases": ["long-chain fatty aldehyde dehydrogenase activity", "fatty aldehyde:NAD+ oxidoreductase activity", "long-chain aliphatic aldehyde dehydrogenase activity", "long-chain-aldehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "long-chain-aldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons. [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324476", "aliases": ["long-chain fatty acyl CoA reductase activity", "acyl coenzyme A reductase activity", "long-chain fatty acyl-CoA reductase activity", "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)"], "types": ["T044"], "canonical_name": "long-chain-fatty-acyl-CoA reductase activity", "definition": "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH. [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]"}
{"concept_id": "C1324477", "aliases": ["formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)", "NAD/factor-dependent formaldehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "mycothiol-dependent formaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+. [EC:1.1.1.306, MetaCyc:1.2.1.66-RXN]"}
{"concept_id": "C1324478", "aliases": ["2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)"], "types": ["T044"], "canonical_name": "oxoglutarate dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP(+) = CO(2) + NADPH + succinyl-CoA. [EC:1.2.1.52, RHEA:21400]"}
{"concept_id": "C1324479", "aliases": ["phenylglyoxylate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "phenylglyoxylate dehydrogenase (acylating) activity", "definition": "Catalysis of the reaction: CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO(2) + NADH. [EC:1.2.1.58, RHEA:10372]"}
{"concept_id": "C1324480", "aliases": ["pyruvate:NADP+ oxidoreductase activity", "pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)", "pyruvate:NADP(+) oxidoreductase activity"], "types": ["T044"], "canonical_name": "pyruvate dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: CoA + NADP(+) + pyruvate = acetyl-CoA + CO(2) + NADPH. [EC:1.2.1.51, RHEA:17425]"}
{"concept_id": "C1324481", "aliases": ["retinal:NAD+ oxidoreductase activity", "cytosolic retinal dehydrogenase activity"], "types": ["T044"], "canonical_name": "retinal dehydrogenase activity", "definition": "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. [EC:1.2.1.36]"}
{"concept_id": "C1324482", "aliases": ["vanillin:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "vanillin dehydrogenase activity", "definition": "Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate. [EC:1.2.1.67, RHEA:13309]"}
{"concept_id": "C1324483", "aliases": ["aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity", "aldehyde dehydrogenase (acceptor) activity"], "types": ["T044"], "canonical_name": "aldehyde dehydrogenase (quinone) activity", "definition": "Catalysis of the reaction: an aldehyde + a quinone + H2O = a carboxylate + a quinol. [EC:1.2.5.2, MetaCyc:1.2.99.3-RXN]"}
{"concept_id": "C1324484", "aliases": ["aldehyde:acceptor oxidoreductase activity", "carboxylic acid reductase activity", "aldehyde:(acceptor) oxidoreductase activity"], "types": ["T044"], "canonical_name": "carboxylate reductase activity", "definition": "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor. [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN]"}
{"concept_id": "C1324485", "aliases": ["cannizzanase activity", "formaldehyde:formaldehyde oxidoreductase activity", "aldehyde dismutase activity", "nicotinoprotein aldehyde dismutase"], "types": ["T044"], "canonical_name": "formaldehyde dismutase activity", "definition": "Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate. [EC:1.2.98.1, MetaCyc:FORMALDEHYDE-DISMUTASE-RXN]"}
{"concept_id": "C1324487", "aliases": ["glyoxylate:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "glyoxylate oxidase activity", "definition": "Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate. [EC:1.2.3.5, RHEA:14837]"}
{"concept_id": "C1324488", "aliases": ["IAA oxidase activity", "indole-3-acetaldehyde oxidase activity", "AO1", "IAAld oxidase activity", "(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity", "indoleacetaldehyde oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (indol-3-yl)acetaldehyde + H(2)O + O(2) = (indol-3-yl)acetate + H(2)O(2) + H(+). [EC:1.2.3.7, RHEA:16277]", "canonical_name": "indole-3-acetaldehyde:oxygen oxidoreductase activity"}
{"concept_id": "C1324489", "aliases": ["oxalate:oxygen oxidoreductase activity", "aero-oxalo dehydrogenase activity", "oxalic acid oxidase activity"], "types": ["T044"], "canonical_name": "oxalate oxidase activity", "definition": "Catalysis of the reaction: 2 H(+) + O(2) + oxalate = 2 CO(2) + H(2)O(2). [RHEA:21880]"}
{"concept_id": "C1324490", "aliases": ["pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)"], "types": ["T044"], "canonical_name": "pyruvate oxidase (CoA-acetylating) activity", "definition": "Catalysis of the reaction: CoA + H(+) + O(2) + pyruvate = acetyl-CoA + CO(2) + H(2)O(2). [EC:1.2.3.6, RHEA:21912]"}
{"concept_id": "C1324491", "aliases": ["phosphate-dependent pyruvate oxidase activity", "pyruvate:oxygen 2-oxidoreductase (phosphorylating)", "pyruvic oxidase activity"], "types": ["T044"], "canonical_name": "pyruvate oxidase activity", "definition": "Catalysis of the reaction: H(+) + O(2) + phosphate + pyruvate = acetyl phosphate + CO(2) + H(2)O(2). [EC:1.2.3.3, RHEA:20848]"}
{"concept_id": "C1324493", "aliases": ["15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN]", "canonical_name": "PebA"}
{"concept_id": "C1324494", "aliases": ["HNA reductase activity", "1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity", "6-oxotetrahydro-nicotinate dehydrogenase activity", "6-oxotetrahydronicotinate dehydrogenase activity", "6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity", "6-hydroxynicotinic reductase activity"], "types": ["T044"], "canonical_name": "6-hydroxynicotinate reductase activity", "definition": "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin. [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN]"}
{"concept_id": "C1324495", "aliases": ["(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity"], "types": ["T044"], "canonical_name": "phycocyanobilin:ferredoxin oxidoreductase activity", "definition": "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN]"}
{"concept_id": "C1324496", "aliases": ["(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity", "PebB"], "types": ["T044"], "canonical_name": "phycoerythrobilin:ferredoxin oxidoreductase activity", "definition": "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin. [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN]"}
{"concept_id": "C1324497", "aliases": ["phytochromobilin synthase activity", "PPhiB synthase activity", "HY2", "phytochromobilin:ferredoxin oxidoreductase activity", "PFB synthase activity", "(3Z)-phytochromobilin:ferredoxin oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN]", "canonical_name": "P-Phi-B synthase activity"}
{"concept_id": "C1324498", "aliases": ["dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity", "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)", "terephthalate 1,2-cis-dihydrodiol dehydrogenase activity", "(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity", "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity", "definition": "Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO(2) + NADH. [EC:1.3.1.53, RHEA:10744]"}
{"concept_id": "C1324499", "aliases": ["17-O-acetylnorajmaline:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "1,2-dihydrovomilenine reductase activity", "definition": "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + H(+) + NADPH. [EC:1.3.1.73, RHEA:12320]"}
{"concept_id": "C1324500", "aliases": ["DHB dehydrogenase activity", "3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity", "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity", "3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity", "dihydrodihydroxybenzoate dehydrogenase activity", "DHBDH activity", "2-hydro-1,2-dihydroxybenzoate dehydrogenase activity", "(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)", "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity", "definition": "Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol. [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN]"}
{"concept_id": "C1324501", "aliases": ["(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity"], "types": ["T044"], "canonical_name": "15-oxoprostaglandin 13-oxidase activity", "definition": "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+. [EC:1.3.1.48, KEGG_REACTION:R04556, KEGG_REACTION:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN]"}
{"concept_id": "C1324502", "aliases": ["2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity", "HDR activity", "NADPH:2'-hydroxydaidzein oxidoreductase activity", "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity", "2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2'-hydroxydaidzein reductase activity", "definition": "Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+. [EC:1.3.1.51, MetaCyc:2'-HYDROXYDAIDZEIN-REDUCTASE-RXN]"}
{"concept_id": "C1324503", "aliases": ["2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity", "NADPH:2'-hydroxyisoflavone oxidoreductase activity", "isoflavone reductase activity", "vestitone:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "2'-hydroxyisoflavone reductase activity", "definition": "Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+. [EC:1.3.1.45, MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN]"}
{"concept_id": "C1324504", "aliases": ["3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity", "melilotate dehydrogenase activity", "coumarate reductase activity"], "types": ["T044"], "canonical_name": "2-coumarate reductase activity", "definition": "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD(+) = trans-2-coumarate + H(+) + NADH. [EC:1.3.1.11, RHEA:21444]"}
{"concept_id": "C1324505", "aliases": ["butanoate:NAD+ delta2-oxidoreductase activity", "enoate reductase activity"], "types": ["T044"], "canonical_name": "2-enoate reductase activity", "definition": "Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+. [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN]"}
{"concept_id": "C1324506", "aliases": ["hexadecanal:NADP+ delta2-oxidoreductase activity", "hexadecanal: NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-hexadecenal reductase activity", "definition": "Catalysis of the reaction: NADP(+) + palmitaldehyde = trans-hexadec-2-enal + H(+) + NADPH. [EC:1.3.1.27, RHEA:12444]"}
{"concept_id": "C1324507", "aliases": ["2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity", "definition": "Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH. [EC:1.3.1.40, RHEA:24268]"}
{"concept_id": "C1324508", "aliases": ["2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-methyl-branched-chain-enoyl-CoA reductase activity", "definition": "Catalysis of the reaction: 2-methylbutanoyl-CoA + NAD(+) = 2-methylbut-2-enoyl-CoA + H(+) + NADH. [PMID:10989435, PMID:6401712, RHEA:43780]"}
{"concept_id": "C1324509", "aliases": ["3-methyloxindole:NADP+ oxidoreductase activity", "3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "3-methyleneoxindole reductase activity", "definition": "Catalysis of the reaction: 3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH. [EC:1.3.1.17, RHEA:20257]"}
{"concept_id": "C1324510", "aliases": ["sterol delta7 reductase activity", "7-dehydrocholesterol reductase activity", "sterol Delta(7)-reductase activity", "sterol delta-7 reductase activity", "cholesterol:NADP+ delta7-oxidoreductase activity", "sterol delta7-reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol. [ISBN:0943088399]", "canonical_name": "7-DHC reductase activity"}
{"concept_id": "C1324512", "aliases": ["a-santonin 1,2-reductase activity", "1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "alpha-santonin 1,2-reductase activity", "definition": "Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+. [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN]"}
{"concept_id": "C1324513", "aliases": ["b-nitroacrylate reductase activity", "3-nitropropanoate:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "beta-nitroacrylate reductase activity", "definition": "Catalysis of the reaction: 3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH. [EC:1.3.1.16, RHEA:23892]"}
{"concept_id": "C1324514", "aliases": ["dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "biochanin-A reductase activity", "definition": "Catalysis of the reaction: dihydrobiochanin A + NADP(+) = biochanin A + H(+) + NADPH. [EC:1.3.1.46, RHEA:12817]"}
{"concept_id": "C1324515", "aliases": ["cholestenone 5alpha-reductase activity", "cholestenone 5a-reductase activity", "delta4-3-ketosteroid 5alpha-oxidoreductase activity", "reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity", "testosterone delta4-hydrogenase activity", "3-oxosteroid 5alpha-reductase activity", "4-ene-5alpha-reductase activity", "cholest-4-en-3-one 5alpha-reductase activity", "steroid 5alpha-hydrogenase activity", "4-ene-3-oxosteroid 5alpha-reductase activity", "testosterone delta4-5alpha-reductase activity", "3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity"], "types": ["T044"], "canonical_name": "cholestenone 5-alpha-reductase activity", "definition": "Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH. [EC:1.3.1.22, RHEA:24552]"}
{"concept_id": "C1324517", "aliases": ["reductase, cis-2-enoyl coenzyme A", "NADPH-dependent cis-enoyl-CoA reductase activity", "acyl-CoA:NADP+ cis-2-oxidoreductase activity", "cis-2-enoyl-coenzyme A reductase activity"], "types": ["T044"], "canonical_name": "cis-2-enoyl-CoA reductase (NADPH) activity", "definition": "Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH. [EC:1.3.1.37, MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN]"}
{"concept_id": "C1324519", "aliases": ["5-beta-reductase activity", "delta4-5beta-reductase activity", "cholestenone 5beta-reductase activity", "5beta-reductase activity", "3-oxo-Delta(4)-steroid 5-beta-reductase activity", "steroid 5-beta-reductase activity", "delta4-hydrogenase activity", "cholestenone 5b-reductase activity", "androstenedione 5-beta-reductase activity", "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity", "delta(4)-5-beta-reductase activity", "delta4-3-oxosteroid 5-beta-reductase activity", "androstenedione 5beta-reductase activity", "cortisone 5-beta-reductase activity", "cortisone delta4-5beta-reductase activity", "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity", "cortisone delta(4)-5-beta-reductase activity", "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity", "delta(4)-3-ketosteroid 5-beta-reductase activity", "cortisone b-reductase activity", "testosterone 5beta-reductase activity", "cholestenone 5-beta-reductase activity", "testosterone 5-beta-reductase activity", "delta4-3-ketosteroid 5beta-reductase activity", "3-oxo-delta4-steroid 5beta-reductase activity", "delta(4)-hydrogenase activity", "cortisone beta-reductase activity", "cortisone 5beta-reductase activity", "steroid 5beta-reductase activity"], "types": ["T044"], "canonical_name": "delta4-3-oxosteroid 5beta-reductase activity", "definition": "Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+. [EC:1.3.1.3, MetaCyc:CORTISONE-BETA-REDUCTASE-RXN]"}
{"concept_id": "C1324520", "aliases": ["NAD(P)H: cucurbitacin B delta23-oxidoreductase activity", "23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity", "cucurbitacin delta(23) reductase activity", "cucurbitacin D23-reductase activity"], "types": ["T044"], "canonical_name": "cucurbitacin delta23-reductase activity", "definition": "Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+. [EC:1.3.1.5, MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN]"}
{"concept_id": "C1324521", "aliases": ["L-arogenate:NAD+ oxidoreductase activity", "arogenate dehydrogenase activity", "pretyrosine dehydrogenase activity", "L-arogenate:NAD(+) oxidoreductase activity", "arogenic dehydrogenase activity", "L-arogenate:NAD+ oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "cyclohexadienyl dehydrogenase activity", "definition": "Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2. [EC:1.3.1.43, MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324523", "aliases": ["lanosterol delta24-reductase activity", "sterol:NADP+ delta24-oxidoreductase activity", "D24-sterol reductase activity"], "types": ["T044"], "canonical_name": "delta24-sterol reductase activity", "definition": "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN]"}
{"concept_id": "C1324525", "aliases": ["geissoschizine:NADP+ 4,21-oxidoreductase activity"], "types": ["T044"], "canonical_name": "geissoschizine dehydrogenase activity", "definition": "Catalysis of the reaction: geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + H(+) + NADPH. [EC:1.3.1.36, RHEA:11376]"}
{"concept_id": "C1324526", "aliases": ["7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity", "7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity", "7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity"], "types": ["T044"], "canonical_name": "kynurenate-7,8-dihydrodiol dehydrogenase activity", "definition": "Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH. [EC:1.3.1.18, RHEA:22248]"}
{"concept_id": "C1324527", "aliases": ["meso-tartrate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "meso-tartrate dehydrogenase activity", "definition": "Catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH. [EC:1.3.1.7, RHEA:18553]"}
{"concept_id": "C1324528", "aliases": ["L-5,6-dihydro-orotate:NAD oxidoreductase activity", "dihydro-orotic dehydrogenase activity", "(S)-dihydroorotate:NADP+ oxidoreductase activity", "orotate reductase activity"], "types": ["T044"], "canonical_name": "orotate reductase (NADPH) activity", "definition": "Catalysis of the reaction: (S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate. [EC:1.3.1.15, RHEA:14861]"}
{"concept_id": "C1324529", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine desaturase activity", "definition": "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + H(+) + NADH. [RHEA:12564]"}
{"concept_id": "C1324530", "aliases": ["progesterone 5a-reductase activity", "5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity", "delta4-steroid 5alpha-reductase (progesterone)", "progesterone 5alpha-reductase activity"], "types": ["T044"], "canonical_name": "progesterone 5-alpha-reductase activity", "definition": "Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH. [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN]"}
{"concept_id": "C1324531", "aliases": ["dihydrodiol dehydrogenase activity", "trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity", "definition": "Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol. [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN]"}
{"concept_id": "C1324532", "aliases": ["acyl-CoA:NAD+ trans-2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "trans-2-enoyl-CoA reductase (NAD+) activity", "definition": "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH. [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN]"}
{"concept_id": "C1324533", "aliases": ["5,12-dihydroxanthommatin:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "xanthommatin reductase activity", "definition": "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin. [EC:1.3.1.41, RHEA:13417]"}
{"concept_id": "C1324534", "aliases": ["dihydrozeatin:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "zeatin reductase activity", "definition": "Catalysis of the reaction: dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin. [EC:1.3.1.69, RHEA:12757]"}
{"concept_id": "C1324535", "aliases": ["2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)", "furoyl-CoA hydroxylase activity", "2-furoyl coenzyme A dehydrogenase activity", "2-furoyl coenzyme A hydroxylase activity", "2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)"], "types": ["T044"], "canonical_name": "2-furoyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 2-furoyl-CoA + A + H(2)O = 5-hydroxy-2-furoyl-CoA + AH(2) + H(+). [EC:1.3.99.8, RHEA:21480]"}
{"concept_id": "C1324536", "aliases": ["3-oxo-5beta-steroid 4-dehydrogenase activity", "3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity", "delta4-3-ketosteroid 5-beta-reductase activity", "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity"], "types": ["T044"], "canonical_name": "3-oxo-5-beta-steroid 4-dehydrogenase activity", "definition": "Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor. [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324537", "aliases": ["3-oxosteroid delta1-dehydrogenase activity", "3-ketosteroid-1-en-dehydrogenase activity", "delta1-steroid reductase activity", "4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity", "3-oxosteroid:(acceptor) delta1-oxidoreductase activity", "3-oxosteroid:acceptor delta1-oxidoreductase activity", "1-ene-dehydrogenase activity", "3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity", "3-ketosteroid-delta1-dehydrogenase activity", "delta1-dehydrogenase activity"], "types": ["T044"], "canonical_name": "3-oxosteroid 1-dehydrogenase activity", "definition": "Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor. [EC:1.3.99.4, MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324538", "aliases": ["cyclohexanone:acceptor 2-oxidoreductase activity", "cyclohexanone:(acceptor) 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "cyclohexanone dehydrogenase activity", "definition": "Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone. [EC:1.3.99.14, RHEA:21780]"}
{"concept_id": "C1324539", "aliases": ["isoquinoline:acceptor 1-oxidoreductase (hydroxylating)"], "types": ["T044"], "canonical_name": "isoquinoline 1-oxidoreductase activity", "definition": "Catalysis of the reaction: A + H(2)O + isoquinoline = AH(2) + isoquinolin-1(2H)-one. [EC:1.3.99.16, RHEA:11588]"}
{"concept_id": "C1324540", "aliases": ["quinaldic acid 4-oxidoreductase activity", "quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)"], "types": ["T044"], "canonical_name": "quinaldate 4-oxidoreductase activity", "definition": "Catalysis of the reaction: A + H(2)O + quinaldate = AH(2) + kynurenate. [EC:1.3.99.18, RHEA:16697]"}
{"concept_id": "C1324541", "aliases": ["quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)", "quinoline-4-carboxylic acid 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "quinoline-4-carboxylate 2-oxidoreductase activity", "definition": "Catalysis of the reaction: A + H(2)O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2). [EC:1.3.99.19, RHEA:14949]"}
{"concept_id": "C1324542", "aliases": ["b,b-carotene-9',10'-dioxygenase activity"], "types": ["T044"], "canonical_name": "beta,beta-carotene-9',10'-dioxygenase activity", "definition": "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone. [PMID:11278918]"}
{"concept_id": "C1324543", "aliases": ["bilirubin:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "bilirubin oxidase activity", "definition": "Catalysis of the reaction: 2 bilirubin + O(2) = 2 biliverdin + 2 H(2)O. [EC:1.3.3.5, RHEA:20980]"}
{"concept_id": "C1324544", "aliases": ["5,6-dihydrouracil:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "dihydrouracil oxidase activity", "definition": "Catalysis of the reaction: 5,6-dihydrouracil + O(2) = H(2)O(2) + uracil. [EC:1.3.3.7, RHEA:12384]"}
{"concept_id": "C1324545", "aliases": ["lathosterol 5-desaturase activity", "delta7-sterol delta5-dehydrogenase activity", "delta7-sterol-C5(6)-desaturase activity", "lathosterol oxidase activity", "delta7-sterol 5-desaturase activity", "5-DES"], "types": ["T044"], "canonical_name": "delta7-sterol 5(6)-desaturase activity", "definition": "Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O. [RHEA:46556]"}
{"concept_id": "C1324546", "aliases": ["loganin:oxygen oxidoreductase (ring-cleaving)"], "types": ["T044"], "canonical_name": "secologanin synthase activity", "definition": "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O. [EC:1.14.19.62, MetaCyc:1.3.3.9-RXN]"}
{"concept_id": "C1324547", "aliases": ["(S)-tetrahydroberberine:oxygen oxidoreductase activity", "THB oxidase activity", "(S)-THB oxidase activity"], "types": ["T044"], "canonical_name": "tetrahydroberberine oxidase activity", "definition": "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2. [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN]"}
{"concept_id": "C1324548", "aliases": ["L-tryptophan:oxygen alpha,beta-oxidoreductase activity", "tryptophan a,b-oxidase activity", "L-tryptophan alpha,beta-dehydrogenase activity", "L-tryptophan 2',3'-oxidase activity"], "types": ["T044"], "canonical_name": "tryptophan alpha,beta-oxidase activity", "definition": "Catalysis of the reaction: L-tryptophan + O(2) = alpha,beta-didehydrotryptophan + H(2)O(2) + H(+). [EC:1.3.3.10, RHEA:19901]"}
{"concept_id": "C1324549", "aliases": ["1,2-dehydroreticulinium ion reductase activity", "(R)-reticuline:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "1,2-dehydroreticulinium reductase (NADPH) activity", "definition": "Catalysis of the reaction: (R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH. [EC:1.5.1.27, RHEA:17569]"}
{"concept_id": "C1324550", "aliases": ["alanopine:NAD oxidoreductase activity", "meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity", "2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)", "alanopine dehydrogenase activity", "alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity", "ADH", "ALPDH"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,2'-iminodipropanoate + H(2)O + NAD(+) = L-alanine + H(+) + NADH + pyruvate. [EC:1.5.1.17, RHEA:17589]", "canonical_name": "alanopine: NAD oxidoreductase activity"}
{"concept_id": "C1324551", "aliases": ["(R)-canadine synthase activity", "(R)-tetrahydroberberine:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "berberine reductase activity", "definition": "Catalysis of the reaction: (R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH. [EC:1.5.1.31, RHEA:21268]"}
{"concept_id": "C1324552", "aliases": ["b-alanopine dehydrogenase activity", "N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)"], "types": ["T044"], "canonical_name": "beta-alanopine dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-beta-alanopine + H(2)O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate. [EC:1.5.1.26, RHEA:21684]"}
{"concept_id": "C1324553", "aliases": ["D(+)-lysopine dehydrogenase activity", "lysopine dehydrogenase activity", "N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)", "D-lysopine synthase activity", "2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)"], "types": ["T044"], "canonical_name": "D-lysopine dehydrogenase activity", "definition": "Catalysis of the reaction: D-lysopine + H(2)O + NADP(+) = L-lysine + H(+) + NADPH + pyruvate. [EC:1.5.1.16, RHEA:17625]"}
{"concept_id": "C1324555", "aliases": ["octopine dehydrogenase activity", "ODH activity", "2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)", "octopine:NAD oxidoreductase activity", "N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)", "D-octopine synthase activity"], "types": ["T044"], "canonical_name": "D-octopine dehydrogenase activity", "definition": "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH. [EC:1.5.1.11, MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324556", "aliases": ["P2C reductase activity", "L-pipecolate:NADP+ 2-oxidoreductase activity", "1,2-didehydropipecolate reductase activity", "1,2-didehydropipecolic reductase activity", "delta 1-piperideine-2-carboxylate reductase activity", "D1-piperideine-2-carboxylate reductase activity"], "types": ["T044"], "canonical_name": "delta1-piperideine-2-carboxylate reductase activity", "definition": "Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate. [EC:1.5.1.21]"}
{"concept_id": "C1324557", "aliases": ["(-)-ephedrine:NAD+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "ephedrine dehydrogenase activity", "definition": "Catalysis of the reaction: (1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH. [EC:1.5.1.18, RHEA:16289]"}
{"concept_id": "C1324558", "aliases": [], "types": ["T044"], "canonical_name": "flavin reductase activity"}
{"concept_id": "C1324560", "aliases": ["N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)", "5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)"], "types": ["T044"], "canonical_name": "N5-(carboxyethyl)ornithine synthase activity", "definition": "Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H(2)O + NADP(+) = L-ornithine + H(+) + NADPH + pyruvate. [EC:1.5.1.24, RHEA:18661]"}
{"concept_id": "C1324561", "aliases": ["nicotinic acid hydroxylase activity", "nicotinate:NADP+ 6-oxidoreductase (hydroxylating)", "nicotinate hydroxylase activity"], "types": ["T044"], "canonical_name": "nicotinate dehydrogenase activity", "definition": "Catalysis of the reaction: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH. [EC:1.17.1.5, RHEA:12236]"}
{"concept_id": "C1324562", "aliases": ["(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)", "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)"], "types": ["T044"], "canonical_name": "opine dehydrogenase activity", "definition": "Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H(2)O + NAD(+) = L-2-aminopentanoate + H(+) + NADH + pyruvate. [EC:1.5.1.28, RHEA:21592]"}
{"concept_id": "C1324563", "aliases": ["5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity", "PTR1", "ptr1 activity"], "types": ["T044"], "canonical_name": "pteridine reductase activity", "definition": "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 H(+) + 2 NADPH. [EC:1.5.1.33, RHEA:19509]"}
{"concept_id": "C1324564", "aliases": ["delta1-pyrroline-2-carboxylate reductase activity", "L-proline:NAD(P)+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "pyrroline-2-carboxylate reductase activity", "definition": "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+. [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN]"}
{"concept_id": "C1324565", "aliases": ["N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)", "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)", "NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)", "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)", "aminoadipic semialdehyde synthase activity", "saccharopin dehydrogenase activity"], "types": ["T044"], "canonical_name": "saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity", "definition": "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH. [EC:1.5.1.9, RHEA:24520]"}
{"concept_id": "C1324566", "aliases": ["6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)", "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)", "saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity", "L-lysine-alpha-ketoglutarate reductase activity", "lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)"], "types": ["T044"], "canonical_name": "saccharopine dehydrogenase (NADP+, L-lysine-forming) activity", "definition": "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH. [EC:1.5.1.8, RHEA:19373]"}
{"concept_id": "C1324567", "aliases": ["N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)", "strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity", "N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "strombine dehydrogenase activity", "definition": "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H(2)O + NAD(+) = glycine + H(+) + NADH + pyruvate. [EC:1.5.1.22, RHEA:14061]"}
{"concept_id": "C1324568", "aliases": ["N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)", "2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)"], "types": ["T044"], "canonical_name": "tauropine dehydrogenase activity", "definition": "Catalysis of the reaction: H(2)O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine. [EC:1.5.1.23, RHEA:12580]"}
{"concept_id": "C1324569", "aliases": ["ketimine reductase activity", "thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity"], "types": ["T044"], "canonical_name": "thiomorpholine-carboxylate dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate. [EC:1.5.1.25, MetaCyc:1.5.1.25-RXN]"}
{"concept_id": "C1324570", "aliases": ["1,2-dihydrovomilenine:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "vomilenine reductase activity", "definition": "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine. [EC:1.5.1.32, RHEA:16409]"}
{"concept_id": "C1324571", "aliases": ["N,N-dimethylglycine oxidase activity", "N,N-dimethylglycine:acceptor oxidoreductase (demethylating)", "N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)"], "types": ["T044"], "canonical_name": "dimethylglycine dehydrogenase activity", "definition": "Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein. [EC:1.5.8.4, RHEA:52856]"}
{"concept_id": "C1324572", "aliases": ["L-pipecolate:(acceptor) 1,6-oxidoreductase activity", "L-pipecolate:acceptor 1,6-oxidoreductase activity"], "types": ["T044"], "canonical_name": "L-pipecolate dehydrogenase activity", "definition": "Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324573", "aliases": ["N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)", "N-methylglutamate dehydrogenase activity", "N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)"], "types": ["T044"], "canonical_name": "methylglutamate dehydrogenase activity", "definition": "Catalysis of the reaction: N-methyl-L-glutamate + A + H(2)O = L-glutamate + AH(2) + formaldehyde. [EC:1.5.99.5, RHEA:22572]"}
{"concept_id": "C1324574", "aliases": ["spermidine dehydrogenase activity", "spermidine:acceptor oxidoreductase activity", "spermidine:(acceptor) oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor. [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN]", "canonical_name": "spermidine dehydrogenase"}
{"concept_id": "C1324575", "aliases": ["dihydrobenzophenanthridine:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "dihydrobenzophenanthridine oxidase activity", "definition": "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine. [EC:1.5.3.12, MetaCyc:1.5.3.12-RXN]"}
{"concept_id": "C1324576", "aliases": ["N,N-dimethylglycine:oxygen oxidoreductase (demethylating)"], "types": ["T044"], "canonical_name": "dimethylglycine oxidase activity", "definition": "Catalysis of the reaction: N,N-dimethylglycine + H(2)O + O(2) = formaldehyde + H(2)O(2) + sarcosine. [EC:1.5.3.10, RHEA:17077]"}
{"concept_id": "C1324577", "aliases": ["L-pipecolic acid oxidase activity", "L-pipecolate:oxygen 1,6-oxidoreductase activity"], "types": ["T044"], "canonical_name": "L-pipecolate oxidase activity", "definition": "Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. [EC:1.5.3.7, RHEA:11992]"}
{"concept_id": "C1324578", "aliases": ["N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)", "N-methylamino acid oxidase activity"], "types": ["T044"], "canonical_name": "N-methyl-L-amino-acid oxidase activity", "definition": "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2. [EC:1.5.3.2, MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN]"}
{"concept_id": "C1324579", "aliases": ["epsilon-alkyl-L-lysine:oxygen oxidoreductase activity", "N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)", "N6-methyllysine oxidase activity", "epsilon-alkyllysinase activity", "6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)", "N(6)-methyllysine oxidase activity", "epsilon-N-methyllysine demethylase activity"], "types": ["T044"], "canonical_name": "N6-methyl-lysine oxidase activity", "definition": "Catalysis of the reaction: N(6)-methyl-L-lysine + H(2)O + O(2) = L-lysine + formaldehyde + H(2)O(2). [EC:1.5.3.4, RHEA:23200]"}
{"concept_id": "C1324580", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin. [GOC:jl]"}
{"concept_id": "C1324581", "aliases": ["DMADh activity", "dimethylamine:electron-transferring flavoprotein oxidoreductase activity"], "types": ["T044"], "canonical_name": "dimethylamine dehydrogenase activity", "definition": "Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine. [EC:1.5.8.1, MetaCyc:1.5.8.1-RXN]"}
{"concept_id": "C1324582", "aliases": ["trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)", "TMADh activity"], "types": ["T044"], "canonical_name": "trimethylamine dehydrogenase activity", "definition": "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein. [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN]"}
{"concept_id": "C1324583", "aliases": ["glycine-cytochrome c reductase activity", "glycine:ferricytochrome-c oxidoreductase (deaminating)", "reductase, glycine-cytochrome c"], "types": ["T044"], "canonical_name": "glycine dehydrogenase (cytochrome) activity", "definition": "Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c. [EC:1.4.2.1, MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN]"}
{"concept_id": "C1324584", "aliases": ["2,4-diaminopentanoic acid C4 dehydrogenase activity", "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "2,4-diaminopentanoate dehydrogenase activity", "definition": "Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+. [EC:1.4.1.12, MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324585", "aliases": ["meso-diaminopimelate dehydrogenase activity", "meso-diaminopimelate D-dehydrogenase activity", "meso-alpha,epsilon-diaminopimelate dehydrogenase activity", "meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "diaminopimelate dehydrogenase activity", "definition": "Catalysis of the reaction: meso-2,6-diaminopimelate + H(2)O + NADP(+) = L-2-amino-6-oxopimelate + H(+) + NADPH + NH(4)(+). [EC:1.4.1.16, RHEA:13561]"}
{"concept_id": "C1324586", "aliases": ["glycine:NAD+ oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "glycine dehydrogenase activity", "definition": "Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH. [EC:1.4.1.10, MetaCyc:GLYCINE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324587", "aliases": ["L-amino-acid:NAD+ oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "L-amino-acid dehydrogenase activity", "definition": "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH. [EC:1.4.1.5, MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324588", "aliases": ["L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)", "L-3,5-diaminohexanoate dehydrogenase activity"], "types": ["T044"], "canonical_name": "L-erythro-3,5-diaminohexanoate dehydrogenase activity", "definition": "Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H(2)O + NAD(+) = (S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH(4)(+). [EC:1.4.1.11, RHEA:19633]"}
{"concept_id": "C1324589", "aliases": ["L-leucine:NAD+ oxidoreductase, deaminating", "L-leucine dehydrogenase activity", "LeuDH activity", "L-leucine:NAD+ oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "leucine dehydrogenase activity", "definition": "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH. [EC:1.4.1.9, MetaCyc:LEUCINE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324590", "aliases": ["L-lysine:NAD+ 6-oxidoreductase (deaminating)", "LysDH activity", "L-lysine 6-dehydrogenase activity", "L-lysine epsilon-dehydrogenase activity"], "types": ["T044"], "canonical_name": "lysine 6-dehydrogenase activity", "definition": "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine. [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN, RHEA:12408]"}
{"concept_id": "C1324591", "aliases": ["L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)"], "types": ["T044"], "canonical_name": "lysine dehydrogenase activity", "definition": "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH. [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324592", "aliases": ["N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)"], "types": ["T044"], "canonical_name": "N-methylalanine dehydrogenase activity", "definition": "Catalysis of the reaction: N-methyl-L-alanine + H(2)O + NADP(+) = H(+) + methylammonium + NADPH + pyruvate. [EC:1.4.1.17, RHEA:21768]"}
{"concept_id": "C1324593", "aliases": ["phenylalanine dehydrogenase activity", "PHD", "L-phenylalanine dehydrogenase activity", "PheDH activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH. [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN]", "canonical_name": "L-phenylalanine:NAD+ oxidoreductase (deaminating)"}
{"concept_id": "C1324594", "aliases": ["L-serine:NAD oxidoreductase (deaminating) activity", "serine dehydrogenase activity", "L-serine:NAD+ 2-oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "serine 2-dehydrogenase activity", "definition": "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH. [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1324595", "aliases": ["TDH", "L-tryptophan dehydrogenase activity", "L-tryptophan:NAD(P)+ oxidoreductase (deaminating)", "tryptophan dehydrogenase activity", "NAD(P)+-L-tryptophan dehydrogenase activity", "TrpDH activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+. [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN]", "canonical_name": "L-Trp-dehydrogenase activity"}
{"concept_id": "C1324596", "aliases": ["valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)", "valine dehydrogenase (NADP+) activity", "L-valine:NADP+ oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "valine dehydrogenase (NADP) activity", "definition": "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH. [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN]"}
{"concept_id": "C1324597", "aliases": ["HCN synthase activity", "glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)", "hydrogen cyanide synthase activity"], "types": ["T044"], "canonical_name": "glycine dehydrogenase (cyanide-forming) activity", "definition": "Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2. [EC:1.4.99.5, MetaCyc:1.4.99.5-RXN]"}
{"concept_id": "C1324598", "aliases": ["taurine:acceptor oxidoreductase (deaminating)", "taurine:(acceptor) oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "taurine dehydrogenase activity", "definition": "Catalysis of the reaction: A + H(2)O + taurine = AH(2) + NH(4)(+) + sulfoacetaldehyde. [EC:1.4.99.2, RHEA:18709]"}
{"concept_id": "C1324599", "aliases": ["D-glutamic oxidase activity", "D-glutamate:oxygen oxidoreductase (deaminating)", "D-glutamic acid oxidase activity"], "types": ["T044"], "canonical_name": "D-glutamate oxidase activity", "definition": "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2. [EC:1.4.3.7, MetaCyc:D-GLUTAMATE-OXIDASE-RXN]"}
{"concept_id": "C1324600", "aliases": ["D-monoaminodicarboxylic acid oxidase activity", "D-glutamic-aspartic oxidase activity", "D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "D-glutamate(D-aspartate) oxidase activity", "definition": "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2, and D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2. [EC:1.4.3.15, MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN]"}
{"concept_id": "C1324601", "aliases": ["ethanolamine:oxygen oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "ethanolamine oxidase activity", "definition": "Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2. [EC:1.4.3.8, MetaCyc:ETHANOLAMINE-OXIDASE-RXN]"}
{"concept_id": "C1324602", "aliases": ["L-glutamic acid oxidase activity", "glutamic acid oxidase activity", "glutamate (acceptor) dehydrogenase activity", "glutamic dehydrogenase (acceptor)", "L-glutamate:oxygen oxidoreductase (deaminating)", "glutamate oxidase activity"], "types": ["T044"], "canonical_name": "L-glutamate oxidase activity", "definition": "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2. [EC:1.4.3.11, MetaCyc:L-GLUTAMATE-OXIDASE-RXN]"}
{"concept_id": "C1324603", "aliases": ["L-lysine alpha-oxidase activity", "L-lysyl-alpha-oxidase activity", "L-lysine:oxygen 2-oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "L-lysine oxidase activity", "definition": "Catalysis of the reaction: L-lysine + H(2)O + O(2) = 6-amino-2-oxohexanoate + H(2)O(2) + NH(4)(+). [EC:1.4.3.14, RHEA:14437]"}
{"concept_id": "C1324604", "aliases": ["putrescine:oxygen oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "putrescine oxidase activity", "definition": "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2. [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN]"}
{"concept_id": "C1324605", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y. [GOC:ai]"}
{"concept_id": "C1324606", "aliases": ["oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide. [GOC:ai]"}
{"concept_id": "C1324607", "aliases": ["5-aminopentanoate:lipoate oxidoreductase (cyclizing)"], "types": ["T044"], "canonical_name": "D-proline reductase (dithiol) activity", "definition": "Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline. [EC:1.21.4.1, MetaCyc:D-PROLINE-REDUCTASE-(DITHIOL)-RXN]"}
{"concept_id": "C1324608", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors", "definition": "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen. [GOC:ai]"}
{"concept_id": "C1324609", "aliases": ["beta-cyclopiazonic oxidocyclase activity", "beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)", "beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)", "beta-cyclopiazonate oxidocyclase activity", "b-cyclopiazonate dehydrogenase activity"], "types": ["T044"], "canonical_name": "beta-cyclopiazonate dehydrogenase activity", "definition": "Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2). [RHEA:14525]"}
{"concept_id": "C1324610", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen. [GOC:ai]"}
{"concept_id": "C1324611", "aliases": ["columbamine:oxygen oxidoreductase (cyclizing)", "berberine synthase activity"], "types": ["T044"], "canonical_name": "columbamine oxidase activity", "definition": "Catalysis of the reaction: 2 columbamine + O(2) = 2 berberine + 2 H(2)O. [RHEA:23564]"}
{"concept_id": "C1324612", "aliases": ["(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)", "berberine bridge enzyme activity", "tetrahydroprotoberberine synthase activity", "BBE", "berberine-bridge-forming enzyme activity"], "types": ["T044"], "canonical_name": "reticuline oxidase activity", "definition": "Catalysis of the reaction: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2) + H(+). [RHEA:19885]"}
{"concept_id": "C1324613", "aliases": ["sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity", "sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)"], "types": ["T044"], "definition": "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H(2)O. [EC:1.21.3.4, RHEA:24092]", "canonical_name": "sulochrin oxidase activity"}
{"concept_id": "C1324614", "aliases": ["sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity", "sulochrin oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H(2)O. [EC:1.21.3.5, RHEA:22616]", "canonical_name": "sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)"}
{"concept_id": "C1324617", "aliases": ["NADH2:cob(II)alamin oxidoreductase activity", "B(12r) reductase activity", "cob(I)alamin:NAD+ oxidoreductase activity", "B12r reductase activity", "vitamin B12r reductase activity", "NADH:cob(II)alamin oxidoreductase activity", "vitamin B(12r) reductase activity", "vitamin B12 reductase activity"], "types": ["T044"], "canonical_name": "cob(II)alamin reductase activity", "definition": "Catalysis of the reaction: 2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH. [RHEA:17481]"}
{"concept_id": "C1324618", "aliases": ["NADH diferric transferrin reductase activity", "diferric transferrin reductase activity", "transferrin reductase activity", "transferrin[Fe(II)]2:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "diferric-transferrin reductase activity", "definition": "Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH. [RHEA:13841]"}
{"concept_id": "C1324619", "aliases": ["phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)", "phytanoyl-CoA hydroxylase activity", "phytanoyl-CoA 2 oxoglutarate dioxygenase activity", "phytanoyl-CoA 2-hydroxylase activity", "phytanoyl-CoA alpha-hydroxylase activity"], "types": ["T044"], "canonical_name": "phytanoyl-CoA dioxygenase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate. [EC:1.14.11.18, RHEA:16065]"}
{"concept_id": "C1324620", "aliases": ["phytoene synthase activity"], "types": ["T044"], "canonical_name": "phytoene synthase activity"}
{"concept_id": "C1324621", "aliases": [], "types": ["T044"], "canonical_name": "quinolinate synthetase A activity", "definition": "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate. [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN]"}
{"concept_id": "C1324623", "aliases": [], "types": ["T045"], "definition": "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon. [GOC:krc, ISBN:0879695897]", "canonical_name": "first spliceosomal transesterification activity"}
{"concept_id": "C1324626", "aliases": [], "types": ["T045"], "definition": "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. [GOC:krc, ISBN:0879695897]", "canonical_name": "second spliceosomal transesterification activity"}
{"concept_id": "C1324629", "aliases": [], "types": ["T044"], "canonical_name": "pyruvyltransferase activity", "definition": "Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another. [GOC:ai]"}
{"concept_id": "C1324630", "aliases": ["acyltransferase, acyl groups converted into alkyl on transfer", "transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"], "types": ["T044"], "canonical_name": "acyltransferase activity, acyl groups converted into alkyl on transfer", "definition": "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. [GOC:jl]"}
{"concept_id": "C1324631", "aliases": ["propylmalic synthase activity", "acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)", "(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity", "propylmalate synthase activity", "2-ethylmalate-3-hydroxybutanedioate synthase activity"], "types": ["T044"], "canonical_name": "2-ethylmalate synthase activity", "definition": "Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H(2)O = (R)-2-ethylmalate + CoA + H(+). [RHEA:23040]"}
{"concept_id": "C1324632", "aliases": ["propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)", "2-methylcitrate oxaloacetate-lyase activity", "methylcitrate synthetase activity", "methylcitrate synthase activity", "MCS activity"], "types": ["T044"], "canonical_name": "2-methylcitrate synthase activity", "definition": "Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+). [RHEA:23780]"}
{"concept_id": "C1324633", "aliases": ["3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity", "2-ethyl-3-hydroxybutanedioate synthase activity", "butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)"], "types": ["T044"], "canonical_name": "3-ethylmalate synthase activity", "definition": "Catalysis of the reaction: butanoyl-CoA + glyoxylate + H(2)O = 3-ethylmalate + CoA + H(+). [RHEA:10500]"}
{"concept_id": "C1324634", "aliases": ["3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity", "3-(n-propyl)-malate synthase activity", "beta-n-propylmalate synthase activity", "N-propylmalate synthase activity", "pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)"], "types": ["T044"], "canonical_name": "3-propylmalate synthase activity", "definition": "Catalysis of the reaction: glyoxylate + H(2)O + pentanoyl-CoA = 3-propylmalate + CoA + H(+). [RHEA:14457]"}
{"concept_id": "C1324635", "aliases": ["(R)-citrate synthase activity", "Re-citrate-synthase activity", "citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity"], "types": ["T044"], "canonical_name": "citrate (Re)-synthase activity", "definition": "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group. [PMID:17400742]"}
{"concept_id": "C1324636", "aliases": ["2-decylcitrate synthase activity", "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)", "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity", "dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)"], "types": ["T044"], "canonical_name": "decylcitrate synthase activity", "definition": "Catalysis of the reaction: H(2)O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+). [RHEA:16605]"}
{"concept_id": "C1324637", "aliases": ["dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)", "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity", "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)", "2-decylhomocitrate synthase activity"], "types": ["T044"], "canonical_name": "decylhomocitrate synthase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + H(2)O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+). [RHEA:10364]"}
{"concept_id": "C1324638", "aliases": [], "types": ["T044"], "canonical_name": "methylthioalkylmalate synthase activity"}
{"concept_id": "C1324639", "aliases": ["acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)", "sulphoacetaldehyde acetyltransferase activity"], "types": ["T044"], "canonical_name": "sulfoacetaldehyde acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde. [RHEA:24204]"}
{"concept_id": "C1324640", "aliases": ["(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity", "agaritine g-glutamyltransferase activity", "(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity"], "types": ["T044"], "canonical_name": "agaritine gamma-glutamyltransferase activity", "definition": "Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor. [EC:2.3.2.9, MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN]"}
{"concept_id": "C1324641", "aliases": ["L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity", "O-alanylphosphatidylglycerol synthase activity", "alanyl phosphatidylglycerol synthetase activity"], "types": ["T044"], "canonical_name": "alanylphosphatidylglycerol synthase activity", "definition": "Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol. [EC:2.3.2.11, MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN]"}
{"concept_id": "C1324642", "aliases": ["beta-aspartyl transferase activity", "aspartotransferase activity", "L-asparagine:hydroxylamine gamma-aspartyltransferase activity"], "types": ["T044"], "canonical_name": "aspartyltransferase activity", "definition": "Catalysis of the reaction: L-asparagine + H(+) + hydroxylamine = beta-L-aspartylhydroxamate + NH(4)(+). [EC:2.3.2.7, RHEA:11252]"}
{"concept_id": "C1324643", "aliases": ["L-glutamine:D-alanine gamma-glutamyltransferase activity", "D-alanine g-glutamyltransferase activity"], "types": ["T044"], "canonical_name": "D-alanine gamma-glutamyltransferase activity", "definition": "Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH(4)(+). [EC:2.3.2.14, RHEA:23556]"}
{"concept_id": "C1324644", "aliases": ["glutamine:D-glutamyl-peptide 5-glutamyltransferase activity", "D-gamma-glutamyl transpeptidase activity", "D-glutamyl transpeptidase activity"], "types": ["T044"], "canonical_name": "D-glutamyltransferase activity", "definition": "Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide. [EC:2.3.2.1, MetaCyc:D-GLUTAMYLTRANSFERASE-RXN]"}
{"concept_id": "C1324646", "aliases": ["L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity", "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity"], "types": ["T044"], "canonical_name": "lysyltransferase activity", "definition": "Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol. [EC:2.3.2.3, MetaCyc:LYSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324647", "aliases": ["uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity", "alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity", "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity", "uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity", "UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity", "UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity", "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity"], "types": ["T044"], "canonical_name": "UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA. [EC:2.3.2.10, MetaCyc:2.3.2.10-RXN]"}
{"concept_id": "C1324648", "aliases": ["13-hydroxylupanine acyltransferase activity", "(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity", "tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity"], "types": ["T044"], "canonical_name": "13-hydroxylupinine O-tigloyltransferase activity", "definition": "Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA. [RHEA:12360]"}
{"concept_id": "C1324649", "aliases": ["ODAP synthase activity", "oxalyldiaminopropionic synthase activity", "oxalyldiaminopropionate synthase activity", "oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity", "oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity", "oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity"], "types": ["T044"], "canonical_name": "2,3-diaminopropionate N-oxalyltransferase activity", "definition": "Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA. [RHEA:13465]"}
{"concept_id": "C1324650", "aliases": ["2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity", "benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity", "benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity", "2alpha-hydroxytaxane 2-O-benzoyltransferase activity", "2a-hydroxytaxane 2-O-benzoyltransferase activity", "benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity"], "types": ["T044"], "canonical_name": "2-alpha-hydroxytaxane 2-O-benzoyltransferase activity", "definition": "Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA. [RHEA:18741]"}
{"concept_id": "C1324651", "aliases": ["acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)", "6-MSAS activity", "MSAS activity"], "types": ["T044"], "canonical_name": "6-methylsalicylic acid synthase activity", "definition": "Catalysis of the reaction: acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO(2) + 4 CoA + H(2)O + NADP(+). [EC:2.3.1.165, RHEA:12240]"}
{"concept_id": "C1324652", "aliases": ["malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)"], "types": ["T044"], "canonical_name": "acridone synthase activity", "definition": "Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H(+) + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO(2) + 4 CoA + H(2)O. [EC:2.3.1.159, RHEA:22224]"}
{"concept_id": "C1324654", "aliases": ["histone lysine acetyltransferase activity (H4-K16 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H4-K16 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4. [EC:2.3.1.48]"}
{"concept_id": "C1324656", "aliases": [], "types": ["T044"], "canonical_name": "azetidine-2-carboxylic acid acetyltransferase activity", "definition": "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid. [PMID:12761200]"}
{"concept_id": "C1324657", "aliases": ["acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "cysteine-S-conjugate N-acetyltransferase activity", "definition": "Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H(+). [EC:2.3.1.80, RHEA:19213]"}
{"concept_id": "C1324658", "aliases": ["D-amino acid acetyltransferase activity", "D-amino acid-alpha-N-acetyltransferase activity", "acetyl-CoA:D-amino-acid N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "D-amino-acid N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid. [EC:2.3.1.36, MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN]"}
{"concept_id": "C1324659", "aliases": ["acetyl-CoA:D-tryptophan N-acetyltransferase activity", "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity", "D-tryptophan acetyltransferase activity"], "types": ["T044"], "canonical_name": "D-tryptophan N-acetyltransferase activity", "definition": "Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H(+). [EC:2.3.1.34, RHEA:10060]"}
{"concept_id": "C1324660", "aliases": ["gentamicin 2'-N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "gentamycin 2'-N-acetyltransferase activity"}
{"concept_id": "C1324661", "aliases": ["glucosamine acetyltransferase activity", "glucosamine acetylase activity", "acetyl-CoA:D-glucosamine N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "glucosamine N-acetyltransferase activity", "definition": "Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H(+). [EC:2.3.1.3, RHEA:21332]"}
{"concept_id": "C1324662", "aliases": ["histidine acetyltransferase activity", "acetylhistidine synthetase activity", "acetyl-CoA:L-histidine N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "histidine N-acetyltransferase activity", "definition": "Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H(+). [EC:2.3.1.33, RHEA:24596]"}
{"concept_id": "C1324663", "aliases": ["acetyl-CoA:imidazole N-acetyltransferase activity", "imidazole acetyltransferase activity", "imidazole acetylase activity"], "types": ["T044"], "canonical_name": "imidazole N-acetyltransferase activity", "definition": "Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA. [EC:2.3.1.2, RHEA:15813]"}
{"concept_id": "C1324664", "aliases": ["leucine acetyltransferase activity", "acetyl-CoA:L-leucine N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "leucine N-acetyltransferase activity", "definition": "Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H(+). [EC:2.3.1.66, RHEA:20089]"}
{"concept_id": "C1324665", "aliases": ["arylhydroxamate N,O-acetyltransferase activity", "acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity", "N-hydroxy-2-aminofluorene-O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "N-hydroxyarylamine O-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine. [EC:2.3.1.118, MetaCyc:2.3.1.118-RXN]"}
{"concept_id": "C1324666", "aliases": ["acetyl-CoA:L-phenylalanine N-acetyltransferase activity", "acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "phenylalanine N-acetyltransferase activity", "definition": "Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H(+). [EC:2.3.1.53, RHEA:17801]"}
{"concept_id": "C1324667", "aliases": ["acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity", "acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity", "tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity", "acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity", "tetrahydrodipicolinate acetylase activity"], "types": ["T044"], "canonical_name": "tetrahydrodipicolinate N-acetyltransferase activity", "definition": "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H(2)O = L-2-acetamido-6-oxopimelate + CoA. [EC:2.3.1.89, RHEA:13085]"}
{"concept_id": "C1324668", "aliases": ["acetyl-CoA:lyso-PAF acetyltransferase activity", "1-alkyl-2-lysolecithin acetyltransferase activity", "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity", "1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity", "acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity", "lysopaf:acetyl CoA acetyltransferase activity", "acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "1-alkylglycerophosphocholine O-acetyltransferase activity", "definition": "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA. [EC:2.3.1.67, MetaCyc:2.3.1.67-RXN]"}
{"concept_id": "C1324669", "aliases": [], "types": ["T044"], "canonical_name": "10-deacetylbaccatin III 10-O-acetyltransferase activity", "definition": "Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA. [EC:2.3.1.167, RHEA:20137]"}
{"concept_id": "C1324670", "aliases": ["acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity", "acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "10-hydroxytaxane O-acetyltransferase activity", "definition": "Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C. [EC:2.3.1.163, RHEA:18837]"}
{"concept_id": "C1324671", "aliases": ["DAT activity", "deacetylvindoline acetyltransferase activity", "acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity", "deacetylvindoline O-acetyltransferase activity", "17-O-deacetylvindoline-17-O-acetyltransferase activity", "acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity", "acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity", "acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity", "acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity", "acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "17-O-deacetylvindoline O-acetyltransferase activity", "definition": "Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA. [EC:2.3.1.107, RHEA:24496]"}
{"concept_id": "C1324672", "aliases": ["alkyllyso-GP:acetyl-CoA acetyltransferase activity", "acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "alkylglycerophosphate 2-O-acetyltransferase activity", "definition": "Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA. [EC:2.3.1.105, RHEA:18557]"}
{"concept_id": "C1324673", "aliases": ["N,O-acetyltransferase activity", "aromatic hydroxylamine acetyltransferase activity", "arylhydroxamate acyltransferase activity", "arylhydroxamic acyltransferase activity", "N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity", "arylhydroxamic acid N,O-acetyltransferase activity", "N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "aromatic-hydroxylamine O-acetyltransferase activity", "definition": "Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl. [EC:2.3.1.56, MetaCyc:2.3.1.56-RXN]"}
{"concept_id": "C1324674", "aliases": ["acetyl-CoA:cortisol O-acetyltransferase activity", "corticosteroid acetyltransferase activity", "corticosteroid-21-O-acetyltransferase activity", "cortisol acetyltransferase activity"], "types": ["T044"], "canonical_name": "cortisol O-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate. [EC:2.3.1.27, RHEA:17073]"}
{"concept_id": "C1324675", "aliases": ["acetyl-CoA:monoterpenol O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "monoterpenol O-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester. [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN]"}
{"concept_id": "C1324676", "aliases": ["acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetylneuraminate 4-O-acetyltransferase activity", "definition": "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA. [EC:2.3.1.44, RHEA:18305]"}
{"concept_id": "C1324677", "aliases": ["acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity", "acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity", "N-acetylneuraminate 7,8-O-acetyltransferase activity", "glycoprotein 7(9)-O-acetyltransferase activity", "acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity", "acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity", "N-acetylneuraminate 7(8)-O-acetyltransferase activity", "N-acetylneuraminate O7-(or O9-)acetyltransferase activity", "acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity", "definition": "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA. [EC:2.3.1.45, MetaCyc:2.3.1.45-RXN]"}
{"concept_id": "C1324678", "aliases": ["acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity", "N6-hydroxylysine:acetyl CoA N6-transacetylase activity", "N(6)-hydroxylysine acetylase activity", "acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity", "N6-hydroxylysine acetylase activity"], "types": ["T044"], "canonical_name": "N6-hydroxylysine O-acetyltransferase activity", "definition": "Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA. [EC:2.3.1.102, RHEA:22388]"}
{"concept_id": "C1324679", "aliases": ["polysialic-acid O-acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9. [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN]", "canonical_name": "acetyl-CoA:polysialic-acid O-acetyltransferase activity"}
{"concept_id": "C1324680", "aliases": ["acetyl-CoA:salutaridinol 7-O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "salutaridinol 7-O-acetyltransferase activity", "definition": "Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA. [EC:2.3.1.150, RHEA:22856]"}
{"concept_id": "C1324681", "aliases": ["acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity", "taxadien-5a-ol O-acetyltransferase activity", "taxadienol acetyltransferase activity", "acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity", "taxadien-5alpha-ol O-acetyltransferase activity", "taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity", "acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "taxadien-5-alpha-ol O-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate. [EC:2.3.1.162, RHEA:22028]"}
{"concept_id": "C1324682", "aliases": ["PAF acetyltransferase activity", "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity"], "types": ["T044"], "canonical_name": "platelet-activating factor acetyltransferase activity", "definition": "Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid. [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN]"}
{"concept_id": "C1324683", "aliases": ["deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity", "deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity", "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity", "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity"], "types": ["T044"], "canonical_name": "deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity", "definition": "Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate. [EC:2.3.1.49, MetaCyc:2.3.1.49-RXN]"}
{"concept_id": "C1324684", "aliases": ["hydrogen-sulfide acetyltransferase activity", "hydrogen-sulphide S-acetyltransferase activity", "acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity"], "types": ["T044"], "canonical_name": "hydrogen-sulfide S-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate. [EC:2.3.1.10, RHEA:16625]"}
{"concept_id": "C1324685", "aliases": ["acetyl-CoA:thioethanolamine S-acetyltransferase activity", "acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity", "thioethanolamine acetyltransferase activity", "thioltransacetylase B activity"], "types": ["T044"], "canonical_name": "thioethanolamine S-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA. [EC:2.3.1.11, RHEA:23280]"}
{"concept_id": "C1324686", "aliases": ["hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity"], "types": ["T044"], "canonical_name": "anthocyanin 5-aromatic acyltransferase activity", "definition": "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA. [EC:2.3.1.153, MetaCyc:2.3.1.153-RXN]"}
{"concept_id": "C1324687", "aliases": ["3-oxopalmitoyl-CoA hydrolase activity", "myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity", "3-oxopalmitoyl-CoA-CoA acetyltransferase activity", "myristoyl-CoA C-acetyltransferase activity"], "types": ["T044"], "canonical_name": "acetyl-CoA C-myristoyltransferase activity", "definition": "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA. [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN]"}
{"concept_id": "C1324688", "aliases": ["1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)"], "types": ["T044"], "canonical_name": "glycerophospholipid acyltransferase (CoA-dependent) activity", "definition": "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine. [EC:2.3.1.148, MetaCyc:2.3.1.148-RXN]"}
{"concept_id": "C1324689", "aliases": [], "types": ["T044"], "canonical_name": "hydroxycinnamoyltransferase activity", "definition": "Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule. [GOC:ai]"}
{"concept_id": "C1324690", "aliases": [], "types": ["T044"], "canonical_name": "O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1324691", "aliases": ["chlorogenate:glucarate caffeoyltransferase activity", "chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity", "chlorogenic acid:glucaric acid O-caffeoyltransferase activity"], "types": ["T044"], "canonical_name": "chlorogenate-glucarate O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate. [EC:2.3.1.98, RHEA:23204]"}
{"concept_id": "C1324692", "aliases": ["galacturate hydroxycinnamoyltransferase activity", "feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity"], "types": ["T044"], "canonical_name": "galactarate O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA. [EC:2.3.1.130, RHEA:12997]"}
{"concept_id": "C1324693", "aliases": ["sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity"], "types": ["T044"], "canonical_name": "glucarate O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA. [EC:2.3.1.131, RHEA:23308]"}
{"concept_id": "C1324694", "aliases": ["sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity"], "types": ["T044"], "canonical_name": "glucarolactone O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA. [EC:2.3.1.132, MetaCyc:2.3.1.132-RXN]"}
{"concept_id": "C1324695", "aliases": ["hydroxycinnamoyl coenzyme A-quinate transferase activity", "feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity"], "types": ["T044"], "canonical_name": "quinate O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA. [EC:2.3.1.99, MetaCyc:2.3.1.99-RXN]"}
{"concept_id": "C1324696", "aliases": ["shikimate hydroxycinnamoyltransferase activity", "4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity"], "types": ["T044"], "canonical_name": "shikimate O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA. [EC:2.3.1.133, MetaCyc:2.3.1.133-RXN]"}
{"concept_id": "C1324697", "aliases": ["sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity", "hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity", "tartronate sinapoyltransferase activity"], "types": ["T044"], "canonical_name": "tartronate O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate. [EC:2.3.1.106, RHEA:10952]"}
{"concept_id": "C1324698", "aliases": ["PHT", "putrescine N-hydroxycinnamoyltransferase activity", "putrescine hydroxycinnamoyl transferase activity", "caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity", "hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity", "caffeoyl-CoA putrescine N-caffeoyl transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H(+). [EC:2.3.1.138, RHEA:12436]", "canonical_name": "putrescine hydroxycinnamoyltransferase activity"}
{"concept_id": "C1324699", "aliases": [], "types": ["T044"], "canonical_name": "N-malonyltransferase activity", "definition": "Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1324700", "aliases": ["malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity"], "types": ["T044"], "canonical_name": "3,4-dichloroaniline N-malonyltransferase activity", "definition": "Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA. [EC:2.3.1.114, RHEA:21060]"}
{"concept_id": "C1324701", "aliases": ["malonyl-CoA:anthranilate N-malonyltransferase activity"], "types": ["T044"], "canonical_name": "anthranilate N-malonyltransferase activity", "definition": "Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA. [EC:2.3.1.113, RHEA:17557]"}
{"concept_id": "C1324702", "aliases": ["malonyl-CoA:D-tryptophan N-malonyltransferase activity"], "types": ["T044"], "canonical_name": "D-tryptophan N-malonyltransferase activity", "definition": "Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H(+). [EC:2.3.1.112, RHEA:23320]"}
{"concept_id": "C1324703", "aliases": [], "types": ["T044"], "canonical_name": "O-malonyltransferase activity", "definition": "Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule. [GOC:ai]"}
{"concept_id": "C1324704", "aliases": ["malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity", "MAT-3", "malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity", "flavonol 3-O-glucoside malonyltransferase activity"], "types": ["T044"], "canonical_name": "flavonol-3-O-beta-glucoside O-malonyltransferase activity", "definition": "Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA. [EC:2.3.1.116, MetaCyc:2.3.1.116-RXN]"}
{"concept_id": "C1324705", "aliases": ["flavone (flavonol) 7-O-glycoside malonyltransferase activity", "malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity", "malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity", "malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity", "malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity", "flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity", "MAT-7"], "types": ["T044"], "canonical_name": "isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity", "definition": "Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA. [EC:2.3.1.115, MetaCyc:2.3.1.115-RXN]"}
{"concept_id": "C1324707", "aliases": ["acyl-CoA:L-glutamine N-acyltransferase activity"], "types": ["T044"], "canonical_name": "glutamine N-acyltransferase activity", "definition": "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine. [EC:2.3.1.68, MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN]"}
{"concept_id": "C1324708", "aliases": ["glycine acyltransferase activity", "acyl-CoA:glycine N-acyltransferase activity", "glycine-N-acylase activity"], "types": ["T044"], "canonical_name": "glycine N-acyltransferase activity", "definition": "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN]"}
{"concept_id": "C1324710", "aliases": ["THDP N-succinyltransferase activity", "tetrahydrodipicolinate N-succinyltransferase activity", "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity", "tetrahydropicolinate succinylase activity", "tetrahydrodipicolinate succinyltransferase activity", "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity", "tetrahydrodipicolinate succinylase activity", "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"], "types": ["T044"], "canonical_name": "2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity", "definition": "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H(2)O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA. [EC:2.3.1.117, RHEA:17325]"}
{"concept_id": "C1324711", "aliases": ["dihydroceramide synthase activity", "sphingosine acyltransferase activity", "sphingosine N-acyltransferase activity", "acyl-CoA:sphingosine N-acyltransferase activity", "ceramide synthetase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]", "canonical_name": "ceramide synthase activity"}
{"concept_id": "C1324712", "aliases": ["lysophosphatidylcholine acyltransferase activity", "acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity", "acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity", "1-acylglycerophosphocholine O-acyltransferase activity", "1-acyl-sn-glycero-3-phosphocholine acyltransferase activity", "lysolecithin acyltransferase activity", "acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]", "canonical_name": "lysophosphatide acyltransferase activity"}
{"concept_id": "C1324713", "aliases": ["acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity"], "types": ["T044"], "canonical_name": "1-alkenylglycerophosphocholine O-acyltransferase activity", "definition": "Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA. [EC:2.3.1.104, MetaCyc:2.3.1.104-RXN]"}
{"concept_id": "C1324714", "aliases": ["acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity"], "types": ["T044"], "canonical_name": "1-alkenylglycerophosphoethanolamine O-acyltransferase activity", "definition": "Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA. [EC:2.3.1.121, MetaCyc:2.3.1.121-RXN]"}
{"concept_id": "C1324715", "aliases": ["1-hexadecyl-2-acetylglycerol acyltransferase activity", "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity"], "types": ["T044"], "canonical_name": "1-alkyl-2-acetylglycerol O-acyltransferase activity", "definition": "Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA. [EC:2.3.1.125, MetaCyc:2.3.1.125-RXN]"}
{"concept_id": "C1324716", "aliases": ["acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity"], "types": ["T044"], "canonical_name": "1-alkylglycerophosphocholine O-acyltransferase activity", "definition": "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA. [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN]"}
{"concept_id": "C1324717", "aliases": ["2-acylglycerophosphate acyltransferase activity", "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity"], "types": ["T044"], "canonical_name": "2-acylglycerol-3-phosphate O-acyltransferase activity", "definition": "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA. [GOC:ab, RHEA:14233]"}
{"concept_id": "C1324718", "aliases": ["2-acylglycerophosphocholine acyltransferase activity", "acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity", "2-acylglycerol-3-phosphorylcholine acyltransferase activity"], "types": ["T044"], "canonical_name": "2-acylglycerophosphocholine O-acyltransferase activity", "definition": "Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA. [RHEA:10332]"}
{"concept_id": "C1324719", "aliases": ["1,2-diacyl-sn-glycerol:sterol acyl transferase activity", "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity"], "types": ["T044"], "canonical_name": "diacylglycerol-sterol O-acyltransferase activity", "definition": "Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol. [EC:2.3.1.73, MetaCyc:2.3.1.73-RXN]"}
{"concept_id": "C1324720", "aliases": ["palmitoyl-CoA:dolichol O-palmitoyltransferase activity", "acyl-CoA:dolichol acyltransferase activity"], "types": ["T044"], "canonical_name": "dolichol O-acyltransferase activity", "definition": "Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate. [EC:2.3.1.123, MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN]"}
{"concept_id": "C1324721", "aliases": ["mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity", "galactolipid:galactolipid acyltransferase activity"], "types": ["T044"], "canonical_name": "galactolipid O-acyltransferase activity", "definition": "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol. [EC:2.3.1.134, MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN]"}
{"concept_id": "C1324722", "aliases": ["acyl-ACP:lyso-MGDG acyltransferase activity", "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity", "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity"], "types": ["T044"], "canonical_name": "galactosylacylglycerol O-acyltransferase activity", "definition": "Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]. [EC:2.3.1.141, MetaCyc:2.3.1.141-RXN]"}
{"concept_id": "C1324724", "aliases": ["indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity", "1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity", "1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity"], "types": ["T044"], "canonical_name": "indoleacetylglucose-inositol O-acyltransferase activity", "definition": "Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose. [EC:2.3.1.72, RHEA:21180]"}
{"concept_id": "C1324725", "aliases": ["wax ester synthase activity", "wax-ester synthase activity", "acyl-CoA:long-chain-alcohol O-acyltransferase activity"], "types": ["T044"], "canonical_name": "long-chain-alcohol O-fatty-acyltransferase activity", "definition": "Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA. [EC:2.3.1.75, MetaCyc:2.3.1.75-RXN]"}
{"concept_id": "C1324726", "aliases": ["fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity", "protein acyltransferase activity"], "types": ["T044"], "canonical_name": "glycoprotein O-fatty-acyltransferase activity", "definition": "Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein. [EC:2.3.1.142, MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN]"}
{"concept_id": "C1324727", "aliases": ["palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity", "myelin PLP acyltransferase activity", "[myelin-proteolipid] O-palmitoyltransferase activity"], "types": ["T044"], "canonical_name": "myelin-proteolipid O-palmitoyltransferase activity", "definition": "Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA. [PMID:3818589]"}
{"concept_id": "C1324728", "aliases": ["sinapine synthase activity", "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity"], "types": ["T044"], "canonical_name": "sinapoylglucose-choline O-sinapoyltransferase activity", "definition": "Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose. [EC:2.3.1.91, RHEA:12024]"}
{"concept_id": "C1324729", "aliases": ["1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity", "hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity", "1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity"], "types": ["T044"], "canonical_name": "sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity", "definition": "Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose. [EC:2.3.1.103, RHEA:22664]"}
{"concept_id": "C1324730", "aliases": ["3-sn-phosphatidylcholine:dolichol O-acyltransferase activity"], "types": ["T044"], "canonical_name": "phosphatidylcholine-dolichol O-acyltransferase activity", "definition": "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol. [EC:2.3.1.83, RHEA:19285]"}
{"concept_id": "C1324731", "aliases": ["phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity", "lecithin--retinol acyltransferase activity", "phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity"], "types": ["T044"], "canonical_name": "phosphatidylcholine-retinol O-acyltransferase activity", "definition": "Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine. [EC:2.3.1.135, MetaCyc:2.3.1.135-RXN]"}
{"concept_id": "C1324732", "aliases": ["retinol fatty-acyltransferase activity", "retinol acyltransferase activity", "acyl-CoA:retinol O-acyltransferase activity"], "types": ["T044"], "canonical_name": "retinol O-fatty-acyltransferase activity", "definition": "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester. [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN]"}
{"concept_id": "C1324733", "aliases": ["triacylglycerol-sterol O-acyltransferase activity", "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity", "triacylglycerol:sterol acyltransferase activity"], "types": ["T044"], "canonical_name": "triglyceride-sterol O-acyltransferase activity", "definition": "Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol. [EC:2.3.1.77, MetaCyc:2.3.1.77-RXN]"}
{"concept_id": "C1324734", "aliases": ["4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity", "4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity", "p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity", "agmatine coumaroyltransferase activity"], "types": ["T044"], "canonical_name": "agmatine N4-coumaroyltransferase activity", "definition": "Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H(+). [EC:2.3.1.64, RHEA:13405]"}
{"concept_id": "C1324735", "aliases": ["1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity"], "types": ["T044"], "canonical_name": "alcohol O-cinnamoyltransferase activity", "definition": "Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate. [EC:2.3.1.152, MetaCyc:2.3.1.152-RXN]"}
{"concept_id": "C1324736", "aliases": [], "types": ["T044"], "canonical_name": "anthranilate N-benzoyltransferase activity", "definition": "Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA. [EC:2.3.1.144, RHEA:21600]"}
{"concept_id": "C1324737", "aliases": ["malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity"], "types": ["T044"], "canonical_name": "tetrahydroxybenzophenone synthase activity", "definition": "Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A. [EC:2.3.1.151, MetaCyc:2.3.1.151-RXN]"}
{"concept_id": "C1324738", "aliases": ["1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity"], "types": ["T044"], "canonical_name": "beta-glucogallin O-galloyltransferase activity", "definition": "Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose. [EC:2.3.1.90, RHEA:11416]"}
{"concept_id": "C1324739", "aliases": ["beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity", "beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity", "1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity", "beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity"], "types": ["T044"], "canonical_name": "beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity", "definition": "Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose. [EC:2.3.1.143, RHEA:19109]"}
{"concept_id": "C1324741", "aliases": ["erythronolide condensing enzyme activity", "malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)"], "types": ["T044"], "canonical_name": "erythronolide synthase activity", "definition": "Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B. [EC:2.3.1.94, MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN]"}
{"concept_id": "C1324742", "aliases": ["phenylacetyl-CoA:L-glutamine N-acetyltransferase activity", "glutamine phenylacetyltransferase activity", "phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity"], "types": ["T044"], "canonical_name": "glutamine N-phenylacetyltransferase activity", "definition": "Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine. [EC:2.3.1.14, MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN]"}
{"concept_id": "C1324743", "aliases": ["1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)", "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)"], "types": ["T044"], "canonical_name": "glycerophospholipid arachidonoyl-transferase (CoA-independent) activity", "definition": "Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine. [EC:2.3.1.147, MetaCyc:2.3.1.147-RXN]"}
{"concept_id": "C1324744", "aliases": ["benzoyl CoA-amino acid N-acyltransferase activity", "benzoyl-CoA:glycine N-acyltransferase activity", "benzoyl-CoA:glycine N-benzoyltransferase activity"], "types": ["T044"], "canonical_name": "glycine N-benzoyltransferase activity", "definition": "Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+). [EC:2.3.1.71, RHEA:18493]"}
{"concept_id": "C1324745", "aliases": ["BACAT activity", "bile acid-CoA:amino acid N-acyltransferase activity", "cholyl-CoA:taurine N-acyltransferase activity", "cholyl-CoA glycine-taurine N-acyltransferase activity", "BAT activity", "amino acid N-choloyltransferase activity", "glycine--taurine N-acyltransferase activity", "choloyl-CoA:glycine N-choloyltransferase activity"], "types": ["T044"], "canonical_name": "glycine N-choloyltransferase activity", "definition": "Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate. [EC:2.3.1.65, MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN]"}
{"concept_id": "C1324746", "aliases": ["caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity"], "types": ["T044"], "canonical_name": "isocitrate O-dihydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA. [EC:2.3.1.126, RHEA:20756]"}
{"concept_id": "C1324748", "aliases": ["mycocerosic acid synthase activity", "acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)"], "types": ["T044"], "canonical_name": "mycocerosate synthase activity", "definition": "Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+). [EC:2.3.1.111, RHEA:10588]"}
{"concept_id": "C1324749", "aliases": ["ornithine N-acyltransferase activity", "benzoyl-CoA:L-ornithine N-benzoyltransferase activity"], "types": ["T044"], "canonical_name": "ornithine N-benzoyltransferase activity", "definition": "Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H(+). [EC:2.3.1.127, RHEA:16929]"}
{"concept_id": "C1324750", "aliases": ["3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity", "valerophenone synthase activity", "isovaleryl-CoA:malonyl-CoA acyltransferase activity"], "types": ["T044"], "canonical_name": "phloroisovalerophenone synthase activity", "definition": "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one. [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN]"}
{"concept_id": "C1324751", "aliases": ["phosphotransbutyrylase activity", "butanoyl-CoA:phosphate butanoyltransferase activity"], "types": ["T044"], "canonical_name": "phosphate butyryltransferase activity", "definition": "Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA. [EC:2.3.1.19, RHEA:20892]"}
{"concept_id": "C1324752", "aliases": ["pine stilbene synthase activity", "malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)"], "types": ["T044"], "canonical_name": "pinosylvin synthase activity", "definition": "Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO(2) + 4 CoA + pinosylvin. [EC:2.3.1.146, RHEA:12552]"}
{"concept_id": "C1324753", "aliases": ["piperidine piperoyltransferase activity", "piperoyl-CoA:piperidine N-piperoyltransferase activity", "(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity"], "types": ["T044"], "canonical_name": "piperidine N-piperoyltransferase activity", "definition": "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H(+). [EC:2.3.1.145, RHEA:14561]"}
{"concept_id": "C1324754", "aliases": ["O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity", "1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity", "lysoplasmenylcholine acyltransferase activity", "acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity"], "types": ["T044"], "canonical_name": "plasmalogen synthase activity", "definition": "Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine. [EC:2.3.1.25, MetaCyc:PLASMALOGEN-SYNTHASE-RXN]"}
{"concept_id": "C1324755", "aliases": ["4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity", "propionyl-CoA C(2)-trimethyltridecanoyltransferase activity", "SCPx", "propionyl-CoA C2-trimethyltridecanoyltransferase activity", "3-oxopristanoyl-CoA thiolase activity", "oxopristanoyl-CoA thiolase activity", "3-oxopristanoyl-CoA hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA. [EC:2.3.1.176, RHEA:10408]", "canonical_name": "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity"}
{"concept_id": "C1324756", "aliases": ["4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity", "caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity", "caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity", "rosmarinic acid synthase activity"], "types": ["T044"], "canonical_name": "rosmarinate synthase activity", "definition": "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate. [EC:2.3.1.140, MetaCyc:ROSMARINATE-SYNTHASE-RXN]"}
{"concept_id": "C1324757", "aliases": ["alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity", "alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity"], "types": ["T044"], "canonical_name": "trehalose O-mycolyltransferase activity", "definition": "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose. [EC:2.3.1.122, RHEA:23472]"}
{"concept_id": "C1324758", "aliases": ["resveratrol synthase activity"], "types": ["T044"], "canonical_name": "trihydroxystilbene synthase activity", "definition": "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. [EC:2.3.1.95, MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN]"}
{"concept_id": "C1324759", "aliases": ["feruloyltyramine synthase activity", "tyramine N-feruloyl-CoA transferase activity", "feruloyl-CoA tyramine N-feruloyl-CoA transferase activity", "tyramine feruloyltransferase activity", "feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity"], "types": ["T044"], "canonical_name": "tyramine N-feruloyltransferase activity", "definition": "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine. [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN]"}
{"concept_id": "C1324760", "aliases": ["acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)"], "types": ["T044"], "canonical_name": "vinorine synthase activity", "definition": "Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine. [EC:2.3.1.160, RHEA:24016]"}
{"concept_id": "C1324761", "aliases": ["oxoglutarate:glyoxylate carboligase activity", "2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity", "oxoglutarate: glyoxylate carboligase activity", "alpha-ketoglutaric-glyoxylic carboligase activity", "2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)", "2-hydroxy-3-oxoadipate synthetase activity"], "types": ["T044"], "canonical_name": "2-hydroxy-3-oxoadipate synthase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2). [EC:2.2.1.5, RHEA:14341]"}
{"concept_id": "C1324762", "aliases": ["1-deoxy-D-altro-heptulose-7-phosphate synthase activity", "3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity", "1-deoxy-D-altro-heptulose-7-phosphate synthetase activity", "3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity"], "types": ["T044"], "canonical_name": "acetoin-ribose-5-phosphate transaldolase activity", "definition": "Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde. [RHEA:21504]"}
{"concept_id": "C1324763", "aliases": ["dihydroxyacetone synthase activity", "DHAS activity", "glycerone synthase activity", "D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity"], "types": ["T044"], "canonical_name": "formaldehyde transketolase activity", "definition": "Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone. [EC:2.2.1.3, MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN]"}
{"concept_id": "C1324764", "aliases": ["p-hydroxybenzoic-polyprenyl transferase activity", "nonaprenyl-4-hydroxybenzoate transferase activity", "4-hydroxybenzoate transferase activity", "p-hydroxybenzoate polyprenyltransferase activity", "p-hydroxybenzoate dimethylallyltransferase activity", "p-hydroxybenzoic acid-polyprenyl transferase activity", "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity"], "types": ["T044"], "canonical_name": "4-hydroxybenzoate nonaprenyltransferase activity", "definition": "Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate. [EC:2.5.1.39, MetaCyc:2.5.1.39-RXN]"}
{"concept_id": "C1324765", "aliases": ["adenosyl methionine cyclotransferase activity", "S-adenosyl-L-methionine alkyltransferase (cyclizing)", "adenosylmethioninase activity"], "types": ["T044"], "canonical_name": "adenosylmethionine cyclotransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone. [EC:2.5.1.4, RHEA:21932]"}
{"concept_id": "C1324766", "aliases": ["dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity", "dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity"], "types": ["T044"], "canonical_name": "aspulvinone dimethylallyltransferase activity", "definition": "Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate. [EC:2.5.1.35, RHEA:13809]"}
{"concept_id": "C1324767", "aliases": ["pyrazolylalaninase activity", "beta-(1-pyrazolyl)alanine synthase activity", "O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity", "beta-pyrazolylalanine synthase (acetylserine) activity", "BPA-synthase activity", "pyrazolealanine synthase activity", "beta-pyrazolealanine synthase activity", "O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity", "O3-acetyl-L-serine acetate-lyase (adding pyrazole)", "3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity"], "types": ["T044"], "canonical_name": "beta-pyrazolylalanine synthase activity", "definition": "Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+). [EC:2.5.1.51, RHEA:13117]"}
{"concept_id": "C1324768", "aliases": ["dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity", "neryl-diphosphate synthase activity"], "types": ["T044"], "canonical_name": "dimethylallylcistransferase activity", "definition": "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate. [EC:2.5.1.28, RHEA:11328]"}
{"concept_id": "C1324769", "aliases": ["S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity", "discadenine synthetase activity"], "types": ["T044"], "canonical_name": "discadenine synthase activity", "definition": "Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H(+). [EC:2.5.1.24, RHEA:19581]"}
{"concept_id": "C1324770", "aliases": ["geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity", "geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity"], "types": ["T044"], "canonical_name": "geranylgeranylglycerol-phosphate geranylgeranyltransferase activity", "definition": "Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate. [EC:2.5.1.42, RHEA:18109]"}
{"concept_id": "C1324771", "aliases": ["spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)"], "types": ["T044"], "canonical_name": "homospermidine synthase (spermidine-specific) activity", "definition": "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine. [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN]"}
{"concept_id": "C1324772", "aliases": ["putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)"], "types": ["T044"], "canonical_name": "homospermidine synthase activity", "definition": "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine. [EC:2.5.1.44, MetaCyc:2.5.1.44-RXN]"}
{"concept_id": "C1324773", "aliases": ["nocardicin aminocarboxypropyltransferase activity", "S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity"], "types": ["T044"], "canonical_name": "isonocardicin synthase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H(+) + isonocardicin A. [EC:2.5.1.38, RHEA:19845]"}
{"concept_id": "C1324774", "aliases": ["3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity", "O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity", "O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)", "O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity"], "types": ["T044"], "canonical_name": "L-mimosine synthase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate. [EC:2.5.1.52, RHEA:12693]"}
{"concept_id": "C1324775", "aliases": ["N-acetylneuraminic acid synthase activity", "NeuAc synthase activity", "N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity", "(NANA)condensing enzyme activity", "phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)"], "types": ["T044"], "canonical_name": "N-acetylneuraminate synthase activity", "definition": "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate. [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN]"}
{"concept_id": "C1324776", "aliases": ["N-acylneuraminate-9-phosphate synthase activity", "N-acetylneuraminate 9-phosphate synthetase activity", "N-acetylneuraminate 9-phosphate lyase activity", "sialic acid 9-phosphate synthetase activity", "N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity", "N-acetylneuraminic acid phosphate synthase activity", "N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate. [EC:2.5.1.57, MetaCyc:4.1.3.20-RXN]", "canonical_name": "phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity"}
{"concept_id": "C1324777", "aliases": ["geranylgeranyl-transferase activity", "geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity", "glycerol phosphate geranylgeranyltransferase activity"], "types": ["T044"], "canonical_name": "phosphoglycerol geranylgeranyltransferase activity", "definition": "Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate. [EC:2.5.1.41, RHEA:23404]"}
{"concept_id": "C1324778", "aliases": [], "types": ["T044"], "canonical_name": "homogentisate phytyltransferase activity", "definition": "Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol. [MetaCyc:RXN-2541, PMID:14512521]"}
{"concept_id": "C1324779", "aliases": ["cis-prenyl transferase activity", "rubber polymerase activity", "isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity", "rubber prenyltransferase activity", "poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity", "rubber allyltransferase activity"], "types": ["T044"], "canonical_name": "rubber cis-polyprenylcistransferase activity", "definition": "Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit. [EC:2.5.1.20, MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN]"}
{"concept_id": "C1324780", "aliases": ["S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity"], "types": ["T044"], "canonical_name": "sym-norspermidine synthase activity", "definition": "Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H(+). [EC:2.5.1.23, RHEA:23244]"}
{"concept_id": "C1324782", "aliases": ["solanesyl-diphosphate synthase activity", "nonaprenyl pyrophosphate synthetase activity", "solanesyl pyrophosphate synthetase activity", "all-trans-nonaprenyl-diphosphate synthase activity", "solanesyl diphosphate synthase activity", "SPP synthase activity", "(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity", "terpenoidallyltransferase activity", "polyprenylpyrophosphate synthetase activity", "terpenyl pyrophosphate synthetase activity", "SPP-synthase activity", "trans-prenyltransferase activity"], "types": ["T044"], "canonical_name": "trans-octaprenyltranstransferase activity", "definition": "Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate. [RHEA:11324]"}
{"concept_id": "C1324783", "aliases": ["(all-trans)-hexaprenyl-diphosphate synthase activity", "hexaprenyl diphosphate synthase activity", "hexaprenyl pyrophosphate synthetase activity"], "types": ["T044"], "canonical_name": "hexaprenyl pyrophosphate synthetase activity", "definition": "OBSOLETE. Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate. [GOC:curators]"}
{"concept_id": "C1324784", "aliases": ["dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity", "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity", "dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity", "dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity"], "types": ["T044"], "canonical_name": "trihydroxypterocarpan dimethylallyltransferase activity", "definition": "Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate. [EC:2.5.1.36, MetaCyc:2.5.1.36-RXN]"}
{"concept_id": "C1324785", "aliases": ["dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity", "dimethylallyltryptophan synthetase activity", "DMAT synthetase activity", "dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity", "4-(gamma,gamma-dimethylallyl)tryptophan synthase activity", "dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity"], "types": ["T044"], "canonical_name": "tryptophan dimethylallyltransferase activity", "definition": "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan. [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN]"}
{"concept_id": "C1324786", "aliases": ["O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity", "isowillardiine synthase activity", "3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity", "O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity", "O3-acetyl-L-serine acetate-lyase (adding uracil)", "Willardiine synthase activity"], "types": ["T044"], "canonical_name": "uracilylalanine synthase activity", "definition": "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate. [RHEA:11496]"}
{"concept_id": "C1324787", "aliases": ["beta-(9-cytokinin)-alanine synthase activity", "O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity", "O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity", "lupinic acid synthetase activity", "beta-(9-cytokinin)alanine synthase activity", "lupinic acid synthase activity", "3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity", "lupinate synthetase activity", "O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)"], "types": ["T044"], "canonical_name": "zeatin 9-aminocarboxyethyltransferase activity", "definition": "Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H(+). [EC:2.5.1.50, RHEA:17333]"}
{"concept_id": "C1324788", "aliases": ["trihexose diphospholipid abequosyltransferase activity", "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity"], "types": ["T044"], "canonical_name": "abequosyltransferase activity", "definition": "Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid. [EC:2.4.1.60, MetaCyc:ABEQUOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324789", "aliases": ["globoside synthetase activity", "galactosylgalactosylglucosylceramide beta-D- activity", "UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity", "UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity", "uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity", "globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity", "globoside synthase activity", "UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity", "beta-3GalNAc-T1 activity", "UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity", "globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity"], "types": ["T044"], "canonical_name": "galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide. [EC:2.4.1.79, MetaCyc:2.4.1.79-RXN]"}
{"concept_id": "C1324790", "aliases": ["Forssman synthase activity", "globoside acetylgalactosaminyltransferase activity", "UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity", "uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity"], "types": ["T044"], "canonical_name": "globoside alpha-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. [EC:2.4.1.88, MetaCyc:2.4.1.88-RXN]"}
{"concept_id": "C1324792", "aliases": ["UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity", "glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity", "N-acetylgalactosaminyltransferase II activity", "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "chondroitin synthase activity", "glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity"], "types": ["T044"], "canonical_name": "glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN]"}
{"concept_id": "C1324793", "aliases": ["glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity", "N-acetylgalactosaminyltransferase I activity", "UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity", "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity"], "types": ["T044"], "canonical_name": "glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP. [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN]"}
{"concept_id": "C1324794", "aliases": ["UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity", "uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. [EC:2.4.1.165, MetaCyc:2.4.1.165-RXN]"}
{"concept_id": "C1324795", "aliases": ["uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity", "core 3beta-GlcNAc-transferase activity", "mucin core 3 beta3-GlcNAc-transferase activity", "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity", "core 3-beta-GlcNAc-transferase activity"], "types": ["T044"], "canonical_name": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP. [EC:2.4.1.147, MetaCyc:2.4.1.147-RXN]"}
{"concept_id": "C1324796", "aliases": ["UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity", "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity", "core 4 beta6-GalNAc-transferase activity"], "types": ["T044"], "canonical_name": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP. [EC:2.4.1.148, MetaCyc:2.4.1.148-RXN]"}
{"concept_id": "C1324798", "aliases": ["UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity", "elongation 3beta-GalNAc-transferase activity", "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity", "elongation 3-beta-GalNAc-transferase activity", "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)"], "types": ["T044"], "canonical_name": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP. [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN]"}
{"concept_id": "C1324799", "aliases": ["UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids. [GOC:bf, PMID:12130631, PMID:12130651]"}
{"concept_id": "C1324800", "aliases": ["N-acetylglucosaminyltransferase III activity", "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity", "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity", "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity", "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity", "GnTIII activity", "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R. [EC:2.4.1.144]"}
{"concept_id": "C1324801", "aliases": ["UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide. [EC:2.4.1.149]"}
{"concept_id": "C1324802", "aliases": ["UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP. [EC:2.4.1.164, MetaCyc:2.4.1.164-RXN]"}
{"concept_id": "C1324803", "aliases": ["glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity", "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity", "alpha-N-acetylglucosaminyltransferase II activity", "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP. [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN]"}
{"concept_id": "C1324804", "aliases": ["lactosylceramide beta-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity", "LA2 synthase activity", "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity", "beta1->3-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "definition": "Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. [EC:2.4.1.206, MetaCyc:2.4.1.206-RXN]"}
{"concept_id": "C1324805", "aliases": ["UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity", "alpha-N-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP. [EC:2.4.1.138, MetaCyc:2.4.1.138-RXN]"}
{"concept_id": "C1324806", "aliases": ["uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity", "UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP. [EC:2.4.1.70, MetaCyc:2.4.1.70-RXN]"}
{"concept_id": "C1324807", "aliases": ["UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity", "hydroxy steroid acetylglucosaminyltransferase activity", "steroid acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "steroid N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H(+) + UDP. [EC:2.4.1.39, RHEA:14153]"}
{"concept_id": "C1324808", "aliases": ["UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity", "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity", "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity", "UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity"], "types": ["T044"], "canonical_name": "undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP. [EC:2.4.1.227, MetaCyc:2.4.1.227-RXN]"}
{"concept_id": "C1324809", "aliases": ["GDP-D-mannuronate:alginate D-mannuronyltransferase activity", "mannuronosyl transferase activity"], "types": ["T044"], "canonical_name": "alginate synthase activity", "definition": "Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1). [EC:2.4.1.33, MetaCyc:ALGINATE-SYNTHASE-RXN]"}
{"concept_id": "C1324810", "aliases": ["GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity", "GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity", "GDP-glucose-glucosephosphate glucosyltransferase activity", "guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity", "GDPglucose-glucose-phosphate glucosyltransferase activity", "trehalose phosphate synthase (GDP-forming) activity"], "types": ["T044"], "canonical_name": "alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity", "definition": "Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP. [EC:2.4.1.36, MetaCyc:2.4.1.36-RXN]"}
{"concept_id": "C1324811", "aliases": ["uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity", "1,3-alpha-D-glucan synthase activity", "UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity", "UDP-glucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity", "a-1,3-glucan synthase activity", "1,3-alpha-glucan synthase activity"], "types": ["T044"], "canonical_name": "alpha-1,3-glucan synthase activity", "definition": "Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1. [EC:2.4.1.183, MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN]"}
{"concept_id": "C1324812", "aliases": ["ADPglucose:protein glucosyltransferase activity", "ADP-glucose:protein 4-alpha-D-glucosyltransferase activity", "adenosine diphosphoglucose-protein glucosyltransferase activity", "ADPglucose:protein 4-alpha-D-glucosyltransferase activity", "1,4alpha-glucan-protein synthase (ADP-forming) activity"], "types": ["T044"], "canonical_name": "alpha-1,4-glucan-protein synthase (ADP-forming) activity", "definition": "Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP. [EC:2.4.1.113, MetaCyc:2.4.1.113-RXN]"}
{"concept_id": "C1324814", "aliases": ["sucrose-1,4-alpha-glucan glucosyltransferase activity", "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity", "sucrose-glucan glucosyltransferase activity"], "types": ["T044"], "canonical_name": "amylosucrase activity", "definition": "Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1). [EC:2.4.1.4, MetaCyc:AMYLOSUCRASE-RXN]"}
{"concept_id": "C1324815", "aliases": ["CEP", "sucrose 6-glucosyltransferase activity", "sucrose-1,6-alpha-glucan glucosyltransferase activity", "SGE", "sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1). [EC:2.4.1.5, MetaCyc:DEXTRANSUCRASE-RXN]", "canonical_name": "dextransucrase activity"}
{"concept_id": "C1324816", "aliases": ["1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity", "dextrin 6-glucosyltransferase activity", "dextran dextrinase activity"], "types": ["T044"], "canonical_name": "dextrin dextranase activity", "definition": "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1). [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN]"}
{"concept_id": "C1324817", "aliases": ["monoglucosyl diacylglycerol (1->2) glucosyltransferase activity", "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity", "DGlcDAG synthase activity", "diglucosyl diacylglycerol (DGlcDAG) synthase activity", "MGlcDAG (1->2) glucosyltransferase activity"], "types": ["T044"], "canonical_name": "diglucosyl diacylglycerol synthase activity", "definition": "Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol. [EC:2.4.1.208, MetaCyc:2.4.1.208-RXN]"}
{"concept_id": "C1324818", "aliases": ["UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity", "UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity", "uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity"], "types": ["T044"], "canonical_name": "flavonol-3-O-glucoside L-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP. [EC:2.4.1.159, MetaCyc:2.4.1.159-RXN]"}
{"concept_id": "C1324819", "aliases": [], "types": ["T044"], "canonical_name": "fructosyltransferase activity", "definition": "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]"}
{"concept_id": "C1324820", "aliases": ["1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity", "2,1-fructan:2,1-fructan 1-fructosyltransferase activity", "2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity", "fructan:fructan fructosyl transferase activity", "1,2-beta-D-fructan 1F-fructosyltransferase activity", "FFT activity", "1,2-beta-D-fructan 1(F)-fructosyltransferase activity", "1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity", "1,2-beta-fructan 1(F)-fructosyltransferase activity"], "types": ["T044"], "canonical_name": "1,2-beta-fructan 1F-fructosyltransferase activity", "definition": "Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1). [EC:2.4.1.100, MetaCyc:2.4.1.100-RXN]"}
{"concept_id": "C1324821", "aliases": ["aldose b-D-fructosyltransferase activity", "alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity"], "types": ["T044"], "canonical_name": "aldose beta-D-fructosyltransferase activity", "definition": "Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside. [EC:2.4.1.162, MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324822", "aliases": ["sucrose:sucrose 1'-beta-D-fructosyltransferase activity", "SST activity", "sucrose-sucrose 1-fructosyltransferase activity", "sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity", "sucrose:sucrose fructosyltransferase activity", "sucrose 1(F)-fructosyltransferase activity", "sucrose:sucrose 1-fructosyltransferase activity", "sucrose:sucrose 1F-beta-D-fructosyltransferase activity"], "types": ["T044"], "canonical_name": "sucrose 1F-fructosyltransferase activity", "definition": "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose. [EC:2.4.1.99, MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324823", "aliases": ["alpha(1,3)-fucosyltransferase activity", "alpha-(1,3)-fucosyltransferase activity", "alpha-1,3-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "alpha-(1->3)-fucosyltransferase activity", "definition": "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage. [GOC:ai]"}
{"concept_id": "C1324824", "aliases": ["alpha-1,6-fucosyltransferase activity", "alpha-(1,6)-fucosyltransferase activity", "alpha(1,6)-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "alpha-(1->6)-fucosyltransferase activity", "definition": "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage. [GOC:ai]"}
{"concept_id": "C1324825", "aliases": ["GDP-L-fucose:polypeptide fucosyltransferase activity", "GDP-fucose:polypeptide fucosyltransferase activity", "GDP-fucose protein O-fucosyltransferase activity", "GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "peptide-O-fucosyltransferase activity", "definition": "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor. [EC:2.4.1.221]"}
{"concept_id": "C1324826", "aliases": ["stachyose synthetase activity", "alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity"], "types": ["T044"], "canonical_name": "galactinol-raffinose galactosyltransferase activity", "definition": "Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol. [EC:2.4.1.67, MetaCyc:2.4.1.67-RXN]"}
{"concept_id": "C1324827", "aliases": ["raffinose synthase activity", "1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity", "galactosyltransferase, galactinol-sucrose", "alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity", "galactinol-sucrose galactosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol. [EC:2.4.1.82, MetaCyc:2.4.1.82-RXN]", "canonical_name": "galactinol:sucrose 6-galactosyl transferase activity"}
{"concept_id": "C1324828", "aliases": ["UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity", "1,6-D-galactosyltransferase activity", "galactogen 6beta-galactosyltransferase activity", "beta-(1,6)-D-galactosyltransferase activity", "UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity", "uridine diphosphogalactose-galactogen galactosyltransferase activity"], "types": ["T044"], "canonical_name": "galactogen 6-beta-galactosyltransferase activity", "definition": "Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP. [EC:2.4.1.205, MetaCyc:2.4.1.205-RXN]"}
{"concept_id": "C1324829", "aliases": ["uridine diphosphogalactose-galactosylxylose galactosyltransferase activity", "UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity", "UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "galactosylxylosylprotein 3-beta-galactosyltransferase activity", "definition": "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP. [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN]"}
{"concept_id": "C1324831", "aliases": ["glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity", "paragloboside synthase activity", "UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity", "GalT-4", "uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. [EC:2.4.1.86, MetaCyc:2.4.1.86-RXN]", "canonical_name": "UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity"}
{"concept_id": "C1324832", "aliases": ["UDPgalactose:glycosaminoglycan D-galactosyltransferase activity", "UDP-galactose:glycosaminoglycan D-galactosyltransferase activity", "uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity"], "types": ["T044"], "canonical_name": "glycosaminoglycan galactosyltransferase activity", "definition": "Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP. [EC:2.4.1.74, MetaCyc:2.4.1.74-RXN]"}
{"concept_id": "C1324833", "aliases": ["UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity", "UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity", "indol-3-ylacetyl-myo-inositol galactoside synthase activity", "uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity"], "types": ["T044"], "canonical_name": "indolylacetyl-myo-inositol galactosyltransferase activity", "definition": "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP. [EC:2.4.1.156, RHEA:21148]"}
{"concept_id": "C1324834", "aliases": ["galactinol synthase activity", "UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity", "uridine diphosphogalactose-inositol galactosyltransferase activity", "UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity", "inositol 1-alpha-galactosyltransferase activity", "UDP-D-galactose:inositol galactosyltransferase activity", "UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "inositol 3-alpha-galactosyltransferase activity", "definition": "Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP. [EC:2.4.1.123, MetaCyc:2.4.1.123-RXN]"}
{"concept_id": "C1324835", "aliases": ["UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity", "lactosylceramide 4-a-galactosyltransferase activity", "Gal-beta-1,4-Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity", "Gal-beta-(1,4)-Glc-beta-1-Cer alpha-(1,4)-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "lactosylceramide 4-alpha-galactosyltransferase activity", "definition": "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP. [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN]"}
{"concept_id": "C1324836", "aliases": ["UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity", "UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity", "uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "lactosylceramide beta-1,3-galactosyltransferase activity", "definition": "Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H(+) + UDP. [EC:2.4.1.179, RHEA:18413]"}
{"concept_id": "C1324837", "aliases": ["UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity", "beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity", "N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity", "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity", "N-acetyllactosaminide alpha-1,3-galactosyltransferase activity", "UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity", "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity", "uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity", "uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity", "beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity", "uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity", "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity", "UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity", "UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity", "glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity", "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity", "UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity", "UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP. [EC:2.4.1.87, MetaCyc:2.4.1.87-RXN, RHEA:13013]", "canonical_name": "UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity"}
{"concept_id": "C1324838", "aliases": ["UDP galactose-N-acylsphingosine galactosyltransferase activity", "UDP-galactose:N-acylsphingosine D-galactosyltransferase activity", "UDPgalactose:N-acylsphingosine D-galactosyltransferase activity", "uridine diphosphogalactose-acylsphingosine galactosyltransferase activity"], "types": ["T044"], "canonical_name": "N-acylsphingosine galactosyltransferase activity", "definition": "Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP. [EC:2.4.1.47, MetaCyc:2.4.1.47-RXN]"}
{"concept_id": "C1324839", "aliases": ["collagen hydroxylysyl galactosyltransferase activity", "UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity", "collagen galactosyltransferase activity", "UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity", "hydroxylysine galactosyltransferase activity", "UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity", "uridine diphosphogalactose-collagen galactosyltransferase activity", "UDP galactose-collagen galactosyltransferase activity"], "types": ["T044"], "canonical_name": "procollagen galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine. [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324840", "aliases": ["raffinose-raffinose a-galactosyltransferase activity", "raffinose:raffinose alpha-galactosyltransferase activity", "raffinose-raffinose alpha-galactosyltransferase activity", "raffinose:raffinose alpha-D-galactosyltransferase activity", "raffinose (raffinose donor) galactosyltransferase activity"], "types": ["T044"], "canonical_name": "raffinose-raffinose alpha-galactotransferase activity", "definition": "Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose. [EC:2.4.1.166, MetaCyc:2.4.1.166-RXN]"}
{"concept_id": "C1324841", "aliases": ["UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity", "UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity", "isofloridoside-phosphate synthase activity", "uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity", "UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity", "glycerol 3-phosphate 1alpha-galactosyltransferase activity", "UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity"], "types": ["T044"], "canonical_name": "sn-glycerol-3-phosphate 1-galactosyltransferase activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP. [EC:2.4.1.96, RHEA:20341]"}
{"concept_id": "C1324842", "aliases": ["UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity", "sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity", "floridoside-phosphate synthase activity", "UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity", "FPS", "UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity", "floridoside phosphate synthetase activity", "floridoside phosphate synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP. [EC:2.4.1.137, RHEA:14285]", "canonical_name": "UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity"}
{"concept_id": "C1324843", "aliases": ["galactosyl-sphingosine transferase activity", "UDP-galactose:sphingosine 1-beta-galactotransferase activity", "UDPgalactose:sphingosine O-galactosyl transferase activity", "psychosine-uridine diphosphate galactosyltransferase activity", "UDPgalactose:sphingosine 1-beta-galactotransferase activity", "psychosine-UDP galactosyltransferase activity", "uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "sphingosine beta-galactosyltransferase activity", "definition": "Catalysis of the reaction: sphingosine + UDP-D-galactose = H(+) + psychosine + UDP. [EC:2.4.1.23, RHEA:19485]"}
{"concept_id": "C1324844", "aliases": ["UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity", "uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity", "UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity", "sucrose 6(F)-alpha-galactosyltransferase activity", "sucrose 6F-alpha-galactosyltransferase activity", "UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "sucrose 6F-alpha-galactotransferase activity", "definition": "Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP. [EC:2.4.1.167, MetaCyc:2.4.1.167-RXN]"}
{"concept_id": "C1324845", "aliases": ["UDP-glucose-diacylglycerol glucosyltransferase activity", "uridine diphosphoglucose-diacylglycerol glucosyltransferase activity", "UDP-glucose:1,2-diacylglycerol glucosyltransferase activity", "UDPglucose:diacylglycerol glucosyltransferase activity", "UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity", "UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "1,2-diacylglycerol 3-glucosyltransferase activity", "definition": "Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP. [EC:2.4.1.157, MetaCyc:2.4.1.157-RXN]"}
{"concept_id": "C1324846", "aliases": ["UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity", "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity", "13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity", "UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity", "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "13-hydroxydocosanoate 13-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP. [EC:2.4.1.158, MetaCyc:2.4.1.158-RXN]"}
{"concept_id": "C1324847", "aliases": ["UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity", "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity", "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP. [EC:2.4.1.202, MetaCyc:2.4.1.202-RXN]"}
{"concept_id": "C1324848", "aliases": ["UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-o-coumarate glucosyltransferase activity", "UDPG:o-coumaric acid O-glucosyltransferase activity", "UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "2-coumarate O-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H(+) + UDP. [EC:2.4.1.114, RHEA:10236]"}
{"concept_id": "C1324849", "aliases": ["HBA glucosyltransferase activity", "UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity", "UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity", "p-hydroxybenzoate glucosyltransferase activity", "UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity", "PHB-O-glucosyltransferase activity", "PHB glucosyltransferase activity"], "types": ["T044"], "canonical_name": "4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP. [EC:2.4.1.194, RHEA:15153]"}
{"concept_id": "C1324850", "aliases": ["uridine diphosphoglucose-alizarin glucosyltransferase activity", "UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity", "UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity", "alizarin 2-b-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "alizarin 2-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP. [EC:2.4.1.103, RHEA:20677]"}
{"concept_id": "C1324851", "aliases": ["UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity", "UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity", "UDP-glucose:cyanidin-3-O-glucosyltransferase activity", "3-GT activity", "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity", "UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "anthocyanidin 3-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP. [EC:2.4.1.115, MetaCyc:2.4.1.115-RXN]"}
{"concept_id": "C1324852", "aliases": ["UDP glucose-arylamine glucosyltransferase activity", "UDPglucose:arylamine N-D-glucosyltransferase activity", "uridine diphosphoglucose-arylamine glucosyltransferase activity", "UDP-glucose:arylamine N-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "arylamine glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine. [EC:2.4.1.71, MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324853", "aliases": ["UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity", "uridine diphosphoglucose-cinnamate glucosyltransferase activity", "cinnamate b-D-glucosyltransferase activity", "cinnamate glucosyltransferase activity", "UDPG:t-cinnamate glucosyltransferase activity", "UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "cinnamate beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP. [EC:2.4.1.177, RHEA:13437]"}
{"concept_id": "C1324854", "aliases": ["UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "cis-p-coumarate glucosyltransferase activity", "definition": "Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP. [EC:2.4.1.209, RHEA:13129]"}
{"concept_id": "C1324855", "aliases": ["cis-zeatin O-b-D-glucosyltransferase activity", "UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity", "UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "cis-zeatin O-beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H(+) + UDP. [EC:2.4.1.215, RHEA:20681]"}
{"concept_id": "C1324856", "aliases": ["UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity", "UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity", "UDP-glucose coniferyl alcohol glucosyltransferase activity", "uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity"], "types": ["T044"], "canonical_name": "coniferyl-alcohol glucosyltransferase activity", "definition": "Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP. [EC:2.4.1.111, MetaCyc:2.4.1.111-RXN]"}
{"concept_id": "C1324857", "aliases": ["UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity", "UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity", "cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity", "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP. [EC:2.4.1.116, MetaCyc:2.4.1.116-RXN]"}
{"concept_id": "C1324858", "aliases": ["uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity", "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity", "UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity", "UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity", "UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity", "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity", "UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity", "cyanohydrin b-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "cyanohydrin beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside. [EC:2.4.1.85, MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324859", "aliases": ["cytokinin 7-b-glucosyltransferase activity", "uridine diphosphoglucose-zeatin 7-glucosyltransferase activity", "cytokinin 7-glucosyltransferase activity", "UDP-glucose:zeatin 7-glucosyltransferase activity", "UDP-glucose-zeatin 7-glucosyltransferase activity", "UDPglucose:zeatin 7-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "cytokinin 7-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event. [EC:2.4.1.118, MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324860", "aliases": [], "types": ["T044"], "canonical_name": "ecdysteroid UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid. [GOC:ai, PMID:10073711]"}
{"concept_id": "C1324861", "aliases": ["hesperetin 7-O-glucosyl-transferase activity", "UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity", "naringenin 7-O-glucosyltransferase activity", "uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity", "UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "flavanone 7-O-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP. [EC:2.4.1.185, MetaCyc:2.4.1.185-RXN]"}
{"concept_id": "C1324862", "aliases": ["UDP-glucose-apigenin beta-glucosyltransferase activity", "UDP-glucose-luteolin beta-D-glucosyltransferase activity", "UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity", "UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity", "flavone 7-O-b-glucosyltransferase activity", "UDPglucose-luteolin beta-D-glucosyltransferase activity", "uridine diphosphoglucose-luteolin glucosyltransferase activity", "UDPglucose-apigenin beta-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "flavone 7-O-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone. [EC:2.4.1.81, MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324863", "aliases": ["uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity", "UDP-glucose:flavonol 3-O-glucosyltransferase activity", "UDP-glucose flavonol 3-O-glucosyltransferase activity", "UDPG:flavonoid-3-O-glucosyltransferase activity", "UDPglucose:flavonol 3-O-D-glucosyltransferase activity", "UDP-glucose:flavonol 3-O-D-glucosyltransferase activity", "GTI"], "types": ["T044"], "canonical_name": "flavonol 3-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside. [EC:2.4.1.91, MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324864", "aliases": ["UDP-glucose:gallate beta-D-glucosyltransferase activity", "UDPglucose:gallate glucosyltransferase activity", "UDPglucose:vanillate 1-O-glucosyltransferase activity", "gallate 1-b-glucosyltransferase activity", "UDPglucose-vanillate 1-glucosyltransferase activity", "UDP-glucose-vanillate 1-glucosyltransferase activity", "UDPglucose:gallate beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "gallate 1-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP. [EC:2.4.1.136, RHEA:15249]"}
{"concept_id": "C1324865", "aliases": ["gibberellin b-glucosyltransferase activity", "uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity", "UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity", "UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "gibberellin beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside. [EC:2.4.1.176, MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324866", "aliases": ["UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity", "arbutin synthase activity", "hydroquinone:O-glucosyltransferase activity", "UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "hydroquinone glucosyltransferase activity", "definition": "Catalysis of the reaction: hydroquinone + UDP-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP. [EC:2.4.1.218, RHEA:12560]"}
{"concept_id": "C1324867", "aliases": ["UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity", "UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity", "uridine diphosphoglucose-anthraquinone glucosyltransferase activity", "anthraquinone-specific glucosyltransferase activity"], "types": ["T044"], "canonical_name": "hydroxyanthraquinone glucosyltransferase activity", "definition": "Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP. [EC:2.4.1.181, MetaCyc:2.4.1.181-RXN]"}
{"concept_id": "C1324868", "aliases": ["UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity", "hydroxycinnamoyl glucosyltransferase activity", "UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity", "UDP-glucose-hydroxycinnamate glucosyltransferase activity"], "types": ["T044"], "canonical_name": "hydroxycinnamate 4-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP. [EC:2.4.1.126, MetaCyc:2.4.1.126-RXN]"}
{"concept_id": "C1324869", "aliases": ["UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity", "cyanohydrin glucosyltransferase activity", "UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity"], "types": ["T044"], "canonical_name": "hydroxymandelonitrile glucosyltransferase activity", "definition": "Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H(+) + taxiphyllin + UDP. [EC:2.4.1.178, RHEA:15961]"}
{"concept_id": "C1324870", "aliases": ["IAA-glucose synthase activity", "IAA-Glu synthetase activity", "UDP-glucose:indol-3-ylacetate glucosyl-transferase activity", "UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity", "uridine diphosphoglucose-indoleacetate glucosyltransferase activity", "UDP-glucose:indol-3-acetic acid glucosyltransferase activity", "UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity", "indol-3-ylacetylglucose synthase activity", "UDPG-indol-3-ylacetyl glucosyl transferase activity", "UDP-glucose:indol-3-ylacetate glucosyltransferase activity", "IAGlu synthase activity"], "types": ["T044"], "canonical_name": "indole-3-acetate beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP. [EC:2.4.1.121, RHEA:14921]"}
{"concept_id": "C1324871", "aliases": ["UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity", "indoxyl-UDPG-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "indoxyl-UDPG glucosyltransferase activity", "definition": "Catalysis of the reaction: indoxyl + UDP-D-glucose = H(+) + indican + UDP. [EC:2.4.1.220, RHEA:12004]"}
{"concept_id": "C1324872", "aliases": ["UDPglucose-flavonoid 7-O-glucosyltransferase activity", "UDPglucose:isoflavone 7-O-glucosyltransferase activity", "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity", "UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity", "UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "isoflavone 7-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside. [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324873", "aliases": ["uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity", "isovitexin b-glucosyltransferase activity", "UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity", "UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "isovitexin beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: isovitexin + UDP-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP. [EC:2.4.1.106, RHEA:19529]"}
{"concept_id": "C1324874", "aliases": ["limonoid UDP-glucosyltransferase activity", "uridine diphosphoglucose-limonoid glucosyltransferase activity", "LGTase activity"], "types": ["T044"], "canonical_name": "limonoid glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP. [EC:2.4.1.210]"}
{"concept_id": "C1324875", "aliases": ["UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity", "uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity", "UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity", "LPS glucosyltransferase II activity"], "types": ["T044"], "canonical_name": "lipopolysaccharide glucosyltransferase II activity", "definition": "Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP. [EC:2.4.1.73, GOC:mr, GOC:pr, MetaCyc:2.4.1.73-RXN]"}
{"concept_id": "C1324876", "aliases": ["uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity", "UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity", "cycasin synthase activity", "UDPglucose-methylazoxymethanol glucosyltransferase activity", "methyl-ONN-azoxymethanol glucosyltransferase activity"], "types": ["T044"], "canonical_name": "methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP. [EC:2.4.1.171, MetaCyc:2.4.1.171-RXN]"}
{"concept_id": "C1324877", "aliases": ["UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-monoterpenol glucosyltransferase activity", "UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity", "UDPglucose:monoterpenol glucosyltransferase activity"], "types": ["T044"], "canonical_name": "monoterpenol beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP. [EC:2.4.1.127, RHEA:11520]"}
{"concept_id": "C1324878", "aliases": ["UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity", "UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity", "UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity", "definition": "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP. [EC:2.4.1.188, MetaCyc:2.4.1.188-RXN]"}
{"concept_id": "C1324879", "aliases": ["UDP-glucose:nicotinic acid-N-glucosyltransferase activity", "nicotinate glucosyltransferase activity", "uridine diphosphoglucose-nicotinate N-glucosyltransferase activity", "UDPglucose:nicotinate N-glucosyltransferase activity", "UDP-glucose:nicotinate N-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "nicotinate-N-glucosyltransferase activity", "definition": "Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP. [EC:2.4.1.196, RHEA:19437]"}
{"concept_id": "C1324880", "aliases": ["UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity", "UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity", "nuatigenin 3beta-glucosyltransferase activity", "uridine diphosphoglucose-nuatigenin glucosyltransferase activity"], "types": ["T044"], "canonical_name": "nuatigenin 3-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: nuatigenin + UDP-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP. [EC:2.4.1.192, RHEA:19329]"}
{"concept_id": "C1324881", "aliases": ["UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity", "UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity", "UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity", "uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "o-dihydroxycoumarin 7-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H(+) + UDP. [EC:2.4.1.104, RHEA:14325]"}
{"concept_id": "C1324882", "aliases": ["UDP-glucosyltransferase activity", "UDPglucosyltransferase activity", "uridine diphosphoglucosyltransferase activity", "phenol-beta-D-glucosyltransferase activity", "UDP-glucose glucosyltransferase activity", "phenol b-glucosyltransferase activity", "UDPglucose:phenol beta-D-glucosyltransferase activity", "UDP-glucose:phenol beta-D-glucosyltransferase activity", "UDP glucosyltransferase activity"], "types": ["T044"], "canonical_name": "phenol beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside. [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324883", "aliases": ["uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity", "UDPglucose:polyprenol monophosphate glucosyltransferase activity", "UDP-glucose:phosphopolyprenol D-glucosyltransferase activity", "UDPglucose:phosphopolyprenol D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "phosphopolyprenol glucosyltransferase activity", "definition": "Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP. [EC:2.4.1.78, MetaCyc:2.4.1.78-RXN]"}
{"concept_id": "C1324884", "aliases": ["UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity", "UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity", "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity", "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "poly(glycerol-phosphate) alpha-glucosyltransferase activity", "definition": "Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP. [EC:2.4.1.52, MetaCyc:2.4.1.52-RXN]"}
{"concept_id": "C1324885", "aliases": ["UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity", "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity", "UDP-D-glucose polyribitol phosphate glucosyl transferase activity", "UDP-D-glucose:polyribitol phosphate glucosyl transferase activity", "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity", "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "poly(ribitol-phosphate) beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP. [EC:2.4.1.53, MetaCyc:2.4.1.53-RXN]"}
{"concept_id": "C1324886", "aliases": ["UDP-glucose-pyridoxine glucosyltransferase activity", "UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity", "uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity", "UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity", "UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "pyridoxine 5'-O-beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP. [EC:2.4.1.160, RHEA:20177]"}
{"concept_id": "C1324887", "aliases": ["UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity", "UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity", "salicyl-alcohol glucosyltransferase activity", "salicyl-alcohol b-D-glucosyltransferase activity", "UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity", "uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "salicyl-alcohol beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H(+) + salicin + UDP. [EC:2.4.1.172, RHEA:11512]"}
{"concept_id": "C1324888", "aliases": ["UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-sarsapogenin glucosyltransferase activity", "sarsapogenin 3beta-glucosyltransferase activity", "UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "sarsapogenin 3-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP. [EC:2.4.1.193, RHEA:14461]"}
{"concept_id": "C1324889", "aliases": ["uridine diphosphoglucose-scopoletin glucosyltransferase activity", "SGTase activity", "UDPglucose:scopoletin O-beta-D-glucosyltransferase activity", "UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity", "UDPglucose:scopoletin glucosyltransferase activity"], "types": ["T044"], "canonical_name": "scopoletin glucosyltransferase activity", "definition": "Catalysis of the reaction: scopoletin + UDP-D-glucose = H(+) + scopolin + UDP. [EC:2.4.1.128, RHEA:20453]"}
{"concept_id": "C1324890", "aliases": ["UDPglucose:sinapate D-glucosyltransferase activity", "UDP-glucose:sinapate D-glucosyltransferase activity", "UDPglucose:sinapic acid glucosyltransferase activity", "uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity", "uridine diphosphoglucose-sinapate glucosyltransferase activity"], "types": ["T044"], "canonical_name": "sinapate 1-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose. [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324891", "aliases": ["GTF-S", "sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity", "sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity", "definition": "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose. [EC:2.4.1.125, MetaCyc:2.4.1.125-RXN]"}
{"concept_id": "C1324892", "aliases": ["desulfoglucosinolate-uridine diphosphate glucosyltransferase activity", "thiohydroximate S-glucosyltransferase activity", "N-hydroxythioamide S-beta-glucosyltransferase activity", "uridine diphosphoglucose-thiohydroximate glucosyltransferase activity", "thiohydroximate glucosyltransferase activity", "UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity", "UDPG:thiohydroximate glucosyltransferase activity", "UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "thiohydroximate beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP. [EC:2.4.1.195, MetaCyc:2.4.1.195-RXN]"}
{"concept_id": "C1324893", "aliases": ["zeatin O-beta-D-glucosyltransferase activity", "UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity", "zeatin O-b-D-glucosyltransferase activity", "UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-zeatin O-glucosyltransferase activity", "zeatin O-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "trans-zeatin O-beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H(+) + UDP. [EC:2.4.1.203, RHEA:23224]"}
{"concept_id": "C1324894", "aliases": ["UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity", "uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity", "UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity", "vitexin b-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "vitexin beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside. [EC:2.4.1.105, RHEA:21956]"}
{"concept_id": "C1324895", "aliases": ["UDPG:vomilenine 21-beta-D-glucosyltransferase activity", "UDPG:vomilenine 21beta-D-glucosyltransferase activity", "vomilenine-glucosyltransferase activity", "UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "vomilenine glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-D-glucose + vomilenine = H(+) + raucaffricine + UDP. [EC:2.4.1.219, RHEA:19385]"}
{"concept_id": "C1324896", "aliases": [], "types": ["T044"], "canonical_name": "asioloorosomucoid beta-1,3-glucuronosyltransferase activity", "definition": "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid. [GOC:bf, PMID:12511570]"}
{"concept_id": "C1324897", "aliases": ["bilirubin glucuronoside glucuronosyltransferase activity", "bilirubin monoglucuronide transglucuronidase activity", "bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "bilirubin-glucuronoside glucuronosyltransferase activity", "definition": "Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside. [RHEA:16885]"}
{"concept_id": "C1324899", "aliases": [], "types": ["T044"], "canonical_name": "galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity", "definition": "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids. [GOC:bf, PMID:12511570]"}
{"concept_id": "C1324900", "aliases": ["uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity", "UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity", "UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity", "luteolin 7-O-glucoronosyltransferase activity", "LGT"], "types": ["T044"], "canonical_name": "luteolin 7-O-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP. [EC:2.4.1.189, RHEA:10568]"}
{"concept_id": "C1324901", "aliases": ["UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity", "LDT", "luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity", "UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity", "uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity", "UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP. [EC:2.4.1.191, RHEA:22116]", "canonical_name": "UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity"}
{"concept_id": "C1324902", "aliases": ["UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity", "luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity", "uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity", "LMT activity", "UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP. [EC:2.4.1.190, RHEA:14149]"}
{"concept_id": "C1324903", "aliases": ["N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity", "chondroitin glucuronyltransferase II activity", "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN]"}
{"concept_id": "C1324904", "aliases": ["N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity", "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity", "heparan glucuronyltransferase II activity", "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN]"}
{"concept_id": "C1324905", "aliases": ["galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetyllactosamine beta-1,3-glucuronosyltransferase activity", "definition": "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine). [GOC:bf, PMID:12511570]"}
{"concept_id": "C1324906", "aliases": ["spHAS", "seHAS", "HAS activity", "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1,4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity", "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "hyaluronan synthase activity", "definition": "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP. [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN]"}
{"concept_id": "C1324907", "aliases": ["sucrose 1-fructosyltransferase activity", "sucrose 1-fructosyl transferase activity", "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity"], "types": ["T044"], "canonical_name": "inulosucrase activity", "definition": "Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1). [EC:2.4.1.9, MetaCyc:INULOSUCRASE-RXN]"}
{"concept_id": "C1324908", "aliases": ["sucrose 6-fructosyl transferase activity", "beta-2,6-fructan:D-glucose 1-fructosyltransferase activity", "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity", "beta-2,6-fructosyltransferase activity", "sucrose 6-fructosyltransferase activity"], "types": ["T044"], "canonical_name": "levansucrase activity", "definition": "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1). [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN]"}
{"concept_id": "C1324909", "aliases": ["UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity", "UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity", "uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity", "uridine diphosphoglucose-ketone glucosyltransferase activity", "UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity", "UDP glucose ketone cyanohydrin glucosyltransferase activity", "uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity"], "types": ["T044"], "canonical_name": "linamarin synthase activity", "definition": "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin. [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN]"}
{"concept_id": "C1324910", "aliases": ["uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity", "LPS N-acetylmannosaminouronosyltransferase activity", "UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity", "ManNAcA transferase activity"], "types": ["T044"], "canonical_name": "lipopolysaccharide N-acetylmannosaminouronosyltransferase activity", "definition": "Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP. [RHEA:28366]"}
{"concept_id": "C1324911", "aliases": ["alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)"], "types": ["T044"], "canonical_name": "maltose synthase activity", "definition": "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate. [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN]"}
{"concept_id": "C1324912", "aliases": ["GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity", "MPG synthase activity"], "types": ["T044"], "canonical_name": "mannosyl-3-phosphoglycerate synthase activity", "definition": "Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+). [EC:2.4.1.217, RHEA:13537]"}
{"concept_id": "C1324913", "aliases": ["mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity", "beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity"], "types": ["T044"], "canonical_name": "beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity", "definition": "Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate. [EC:2.4.1.199, MetaCyc:2.4.1.199-RXN]"}
{"concept_id": "C1324914", "aliases": ["guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity", "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity", "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity"], "types": ["T044"], "canonical_name": "chitobiosyldiphosphodolichol beta-mannosyltransferase activity", "definition": "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol. [EC:2.4.1.142]"}
{"concept_id": "C1324915", "aliases": ["GDP-man-beta-mannan mannosyltransferase activity", "GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity", "glucomannan 4-b-mannosyltransferase activity", "glucomannan-synthase activity"], "types": ["T044"], "canonical_name": "glucomannan 4-beta-mannosyltransferase activity", "definition": "Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP. [EC:2.4.1.32, MetaCyc:2.4.1.32-RXN]"}
{"concept_id": "C1324916", "aliases": ["guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity", "GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity", "heteropolysaccharide alpha-mannosyltransferase activity", "GDP mannose alpha-mannosyltransferase activity"], "types": ["T044"], "canonical_name": "heteroglycan alpha-mannosyltransferase activity", "definition": "Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP. [EC:2.4.1.48]"}
{"concept_id": "C1324917", "aliases": ["GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity", "GDP mannose-undecaprenyl phosphate mannosyltransferase activity", "GDP-D-mannose:lipid phosphate transmannosylase activity", "guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity"], "types": ["T044"], "canonical_name": "undecaprenyl-phosphate mannosyltransferase activity", "definition": "Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol. [EC:2.4.1.54]"}
{"concept_id": "C1324918", "aliases": ["UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity", "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity", "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity", "N-acetylmannosaminyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity", "definition": "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP. [EC:2.4.1.187, MetaCyc:2.4.1.187-RXN]"}
{"concept_id": "C1324919", "aliases": ["laminarin phosphoryltransferase activity", "1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity", "1,3-beta-glucan phosphorylase activity", "1,3-beta-D-glucan:orthophosphate glucosyltransferase activity"], "types": ["T044"], "canonical_name": "1,3-beta-D-glucan phosphorylase activity", "definition": "Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin. [EC:2.4.1.97, MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN]"}
{"concept_id": "C1324920", "aliases": ["beta-1,3-galactosyl-N-acetylhexosamine phosphorylase activity", "beta-D-galactopyranosyl-(1,3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity", "beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity"], "types": ["T044"], "canonical_name": "1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity", "definition": "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate. [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN]"}
{"concept_id": "C1324921", "aliases": ["beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity", "beta-1,3-oligoglucan phosphorylase activity", "1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "1,3-beta-oligoglucan phosphorylase activity", "definition": "Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate. [EC:2.4.1.30, MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN]"}
{"concept_id": "C1324922", "aliases": ["a,a-trehalose phosphorylase activity", "trehalose phosphorylase", "alpha,alpha-trehalose phosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate. [EC:2.4.1.64, MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN]", "canonical_name": "alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity"}
{"concept_id": "C1324923", "aliases": ["cellobiose:phosphate alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "cellobiose phosphorylase activity", "definition": "Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose. [EC:2.4.1.20, MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN]"}
{"concept_id": "C1324924", "aliases": ["1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity", "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity"], "types": ["T044"], "canonical_name": "cellodextrin phosphorylase activity", "definition": "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN]"}
{"concept_id": "C1324925", "aliases": ["3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "laminaribiose phosphorylase activity", "definition": "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate. [EC:2.4.1.31, MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN]"}
{"concept_id": "C1324926", "aliases": ["maltose:phosphate 1-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "maltose phosphorylase activity", "definition": "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate. [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN]"}
{"concept_id": "C1324927", "aliases": ["trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "trehalose 6-phosphate phosphorylase activity", "definition": "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate. [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN]"}
{"concept_id": "C1324928", "aliases": ["UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity", "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity", "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity"], "types": ["T044"], "canonical_name": "polygalacturonate 4-alpha-galacturonosyltransferase activity", "definition": "Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP. [EC:2.4.1.43, MetaCyc:2.4.1.43-RXN]"}
{"concept_id": "C1324931", "aliases": ["CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity"], "types": ["T044"], "canonical_name": "galactosyldiacylglycerol alpha-2,3-sialyltransferase activity", "definition": "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+). [EC:2.4.99.5, RHEA:11664]"}
{"concept_id": "C1324932", "aliases": ["CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity", "GM3 synthetase activity", "lactosylceramide alpha-2,6-N-sialyltransferase activity", "GM3 synthase activity", "lactosylceramide alpha-2,3-sialyltransferase activity", "cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity", "CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity", "CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity", "CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity", "ganglioside GM3 synthase activity", "ganglioside GM3 synthetase activity", "SAT 1", "CMP-sialic acid:lactosylceramide-sialyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3. [EC:2.4.99.9, MetaCyc:2.4.99.9-RXN]", "canonical_name": "CMP-sialic acid:lactosylceramide sialyltransferase activity"}
{"concept_id": "C1324934", "aliases": ["CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity"], "types": ["T044"], "canonical_name": "monosialoganglioside sialyltransferase activity", "definition": "Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP. [EC:2.4.99.2, MetaCyc:2.4.99.2-RXN]"}
{"concept_id": "C1324935", "aliases": ["1,4-beta-xylan synthase activity", "UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity", "xylan synthase activity", "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity", "xylan synthetase activity"], "types": ["T044"], "canonical_name": "1,4-beta-D-xylan synthase activity", "definition": "Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1). [EC:2.4.2.24, MetaCyc:1,4-BETA-D-XYLAN-SYNTHASE-RXN]"}
{"concept_id": "C1324936", "aliases": ["deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity", "2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity", "deoxyuridine:phosphate deoxy-D-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "deoxyuridine phosphorylase activity", "definition": "Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate. [EC:2.4.2.23, MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN]"}
{"concept_id": "C1324937", "aliases": ["dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity", "2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity", "dioxotetrahydropyrimidine phosphoribosyl transferase activity", "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity", "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity"], "types": ["T044"], "canonical_name": "dioxotetrahydropyrimidine phosphoribosyltransferase activity", "definition": "Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine. [EC:2.4.2.20, MetaCyc:2.4.2.20-RXN]"}
{"concept_id": "C1324938", "aliases": ["dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity", "dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity", "thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity"], "types": ["T044"], "canonical_name": "dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity", "definition": "Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H(+). [EC:2.4.2.27, RHEA:24392]"}
{"concept_id": "C1324939", "aliases": ["UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity", "uridine diphosphoapiose-flavone apiosyltransferase activity", "UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity"], "types": ["T044"], "canonical_name": "flavone apiosyltransferase activity", "definition": "Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone. [EC:2.4.2.25, MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324940", "aliases": ["guanosine:phosphate alpha-D-ribosyltransferase activity", "guanosine:phosphate D-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "guanosine phosphorylase activity", "definition": "Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate. [EC:2.4.2.15, MetaCyc:GUANPHOSPHOR-RXN]"}
{"concept_id": "C1324941", "aliases": ["UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity", "arabinosylindolylacetylinositol synthase activity", "UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity"], "types": ["T044"], "canonical_name": "indolylacetylinositol arabinosyltransferase activity", "definition": "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP. [EC:2.4.2.34, RHEA:19505]"}
{"concept_id": "C1324942", "aliases": ["NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity", "NAD--azoferredoxin (ADP-ribose)transferase activity", "NAD-azoferredoxin (ADPribose)transferase activity", "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity"], "types": ["T044"], "canonical_name": "NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity", "definition": "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]. [EC:2.4.2.37]"}
{"concept_id": "C1324943", "aliases": ["NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity", "NAD-diphthamide ADP-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "NAD+-diphthamide ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide. [EC:2.4.2.36]"}
{"concept_id": "C1324944", "aliases": ["NMN pyrophosphorylase activity", "nicotinamide mononucleotide pyrophosphorylase activity", "nicotinamide mononucleotide synthetase activity", "NMN synthetase activity", "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity", "NMN diphosphorylase activity"], "types": ["T044"], "canonical_name": "nicotinamide phosphoribosyltransferase activity", "definition": "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide. [RHEA:16149]"}
{"concept_id": "C1324945", "aliases": ["purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity", "nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity", "deoxyribose transferase activity", "trans-deoxyribosylase activity", "trans-N-deoxyribosylase activity", "trans-N-glycosidase activity", "nucleoside trans-N-deoxyribosylase activity"], "types": ["T044"], "canonical_name": "nucleoside deoxyribosyltransferase activity", "definition": "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1. [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324946", "aliases": ["nucleoside:purine(pyrimidine) D-ribosyltransferase activity", "nucleoside N-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "nucleoside ribosyltransferase activity", "definition": "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1. [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN]"}
{"concept_id": "C1324947", "aliases": ["UAR phosphorylase activity", "urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity", "urate-ribonucleotide:phosphate D-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "urate-ribonucleotide phosphorylase activity", "definition": "Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H(+) + urate. [EC:2.4.2.16, RHEA:13909]"}
{"concept_id": "C1324948", "aliases": ["UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity"], "types": ["T044"], "canonical_name": "dolichyl-phosphate D-xylosyltransferase activity", "definition": "Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP. [EC:2.4.2.32, MetaCyc:2.4.2.32-RXN]"}
{"concept_id": "C1324949", "aliases": ["dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity"], "types": ["T044"], "canonical_name": "dolichyl-xylosyl-phosphate-protein xylosyltransferase activity", "definition": "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein. [EC:2.4.2.33, MetaCyc:2.4.2.33-RXN]"}
{"concept_id": "C1324950", "aliases": ["UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity"], "types": ["T044"], "canonical_name": "flavonol-3-O-glycoside xylosyltransferase activity", "definition": "Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP. [EC:2.4.2.35, MetaCyc:2.4.2.35-RXN]"}
{"concept_id": "C1324951", "aliases": ["beta-1,2-xylosyltransferase activity", "glycoprotein 2-b-D-xylosyltransferase activity", "1,2-beta-xylosyltransferase activity"], "types": ["T044"], "canonical_name": "glycoprotein 2-beta-D-xylosyltransferase activity", "definition": "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H(+) + UDP. [EC:2.4.2.38, RHEA:10612]"}
{"concept_id": "C1324952", "aliases": ["zeatin O-b-D-xylosyltransferase activity", "zeatin O-xylosyltransferase activity", "UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity", "uridine diphosphoxylose-zeatin xylosyltransferase activity"], "types": ["T044"], "canonical_name": "zeatin O-beta-D-xylosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H(+) + UDP. [EC:2.4.2.40, RHEA:14721]"}
{"concept_id": "C1324953", "aliases": ["oximase activity", "pyruvate-acetone oximinotransferase activity", "oximinotransferase activity", "transoximinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate. [RHEA:11624]", "canonical_name": "transoximase activity"}
{"concept_id": "C1324955", "aliases": ["D-3-aminoisobutyrate--pyruvate aminotransferase activity", "D-3-aminoisobutyrate-pyruvate transaminase activity", "(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity", "D-beta-aminoisobutyrate:pyruvate aminotransferase activity", "beta-aminoisobutyrate--pyruvate transaminase activity", "(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity", "D-3-aminoisobutyrate--pyruvate transaminase activity", "beta-aminoisobutyrate-pyruvate aminotransferase activity", "(R)-3-amino-2-methylpropanoate transaminase activity", "(R)-3-amino-2-methylpropanoate aminotransferase activity", "D-AIBAT activity", "(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity", "(R)-3-amino-2-methylpropionate transaminase activity"], "types": ["T044"], "canonical_name": "(R)-3-amino-2-methylpropionate-pyruvate transaminase activity", "definition": "Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine. [EC:2.6.1.40, RHEA:18393]"}
{"concept_id": "C1324956", "aliases": ["beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity", "L-3-aminoisobutyrate transaminase activity", "(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity", "L-3-aminoisobutyric aminotransferase activity", "(S)-3-amino-2-methylpropionate aminotransferase activity", "L-AIBAT activity", "L-3-aminoisobutyrate aminotransferase activity", "beta-aminobutyric transaminase activity"], "types": ["T044"], "canonical_name": "(S)-3-amino-2-methylpropionate transaminase activity", "definition": "Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate. [EC:2.6.1.22, RHEA:13993]"}
{"concept_id": "C1324957", "aliases": ["guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity", "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity", "L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity", "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity"], "types": ["T044"], "canonical_name": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity", "definition": "Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine. [EC:2.6.1.56, RHEA:15497]"}
{"concept_id": "C1324958", "aliases": ["diamino acid aminotransferase activity", "2,5-diaminovalerate aminotransferase activity", "2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity", "diamino-acid transaminase activity", "diamino-acid aminotransferase activity"], "types": ["T044"], "canonical_name": "2,5-diaminovalerate transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + ornithine = 5-amino-2-oxopentanoate + L-glutamate. [EC:2.6.1.8, RHEA:16017]"}
{"concept_id": "C1324959", "aliases": ["2-aminoadipic aminotransferase activity", "alpha-aminoadipate aminotransferase activity", "L-2-aminoadipate:2-oxoglutarate aminotransferase activity", "glutamate-alpha-ketoadipate transaminase activity", "2-aminoadipate aminotransferase activity", "glutamic-ketoadipic transaminase activity"], "types": ["T044"], "canonical_name": "2-aminoadipate transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate. [EC:2.6.1.39, RHEA:12601]"}
{"concept_id": "C1324960", "aliases": ["2-aminoethylphosphonate--pyruvate aminotransferase activity", "(2-aminoethyl)phosphonic acid aminotransferase activity", "(2-aminoethyl)phosphonate transaminase activity", "(2-aminoethyl)phosphonate aminotransferase activity", "2-aminoethylphosphonate-pyruvate aminotransferase activity", "(2-aminoethyl)phosphonate--pyruvate aminotransferase activity", "2-aminoethylphosphonate aminotransferase activity", "(2-aminoethyl)phosphonate:pyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "2-aminoethylphosphonate-pyruvate transaminase activity", "definition": "Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde. [EC:2.6.1.37, RHEA:17021]"}
{"concept_id": "C1324961", "aliases": ["norleucine (leucine) aminotransferase activity", "norleucine aminotransferase activity", "norleucine transaminase activity", "2-aminohexanoate aminotransferase activity", "leucine L-norleucine: 2-oxoglutarate aminotransferase activity", "L-2-aminohexanoate:2-oxoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "2-aminohexanoate transaminase activity", "definition": "Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate. [EC:2.6.1.67, MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN]"}
{"concept_id": "C1324962", "aliases": ["4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity", "4-hydroxyglutamate aminotransferase activity"], "types": ["T044"], "canonical_name": "4-hydroxyglutamate transaminase activity", "definition": "Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate. [EC:2.6.1.23, MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN]"}
{"concept_id": "C1324963", "aliases": ["5-aminopentanoate:2-oxoglutarate aminotransferase activity", "delta-aminovalerate transaminase activity", "5-aminovalerate aminotransferase activity", "delta-aminovalerate aminotransferase activity"], "types": ["T044"], "canonical_name": "5-aminovalerate transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate. [EC:2.6.1.48, RHEA:10212]"}
{"concept_id": "C1324964", "aliases": ["alanine-keto acid aminotransferase activity", "alanine-oxo acid aminotransferase activity", "L-alanine-alpha-keto acid aminotransferase activity", "alanine--oxo-acid aminotransferase activity", "alanine-oxo-acid aminotransferase activity", "L-alanine:2-oxo-acid aminotransferase activity", "leucine-alanine transaminase activity"], "types": ["T044"], "canonical_name": "alanine-oxo-acid transaminase activity", "definition": "Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid. [EC:2.6.1.12, MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN]"}
{"concept_id": "C1324965", "aliases": ["alanine--oxomalonate aminotransferase activity", "L-alanine-ketomalonate transaminase activity", "alanine-ketomalonate (mesoxalate) transaminase activity", "alanine-oxomalonate aminotransferase activity", "L-alanine:oxomalonate aminotransferase activity"], "types": ["T044"], "canonical_name": "alanine-oxomalonate transaminase activity", "definition": "Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate. [EC:2.6.1.47, RHEA:18809]"}
{"concept_id": "C1324966", "aliases": ["4,5-dioxovaleric transaminase activity", "alanine-dioxovalerate aminotransferase activity", "aminolevulinate aminotransferase activity", "DOVA transaminase activity", "alanine-gamma,delta-dioxovalerate aminotransferase activity", "L-alanine:dioxovalerate transaminase activity", "gamma,delta-dioxovaleric acid transaminase activity", "L-alanine-4,5-dioxovalerate aminotransferase activity", "5-aminolevulinate:pyruvate aminotransferase activity", "4,5-dioxovaleric acid aminotransferase activity", "L-alanine:4,5-dioxovaleric acid transaminase activity", "gamma,delta-dioxovalerate aminotransferase activity", "dioxovalerate transaminase activity", "4,5-dioxovaleric acid transaminase activity", "5-aminolevulinic acid transaminase activity", "4,5-dioxovalerate aminotransferase activity", "aminolevulinic acid transaminase activity", "alanine:4,5-dioxovalerate aminotransferase activity"], "types": ["T044"], "canonical_name": "aminolevulinate transaminase activity", "definition": "Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine. [EC:2.6.1.43, RHEA:12480]"}
{"concept_id": "C1324967", "aliases": ["aromatic-amino-acid:glyoxylate aminotransferase activity", "aromatic-amino-acid-glyoxylate aminotransferase activity", "aromatic-amino-acid--glyoxylate aminotransferase activity"], "types": ["T044"], "canonical_name": "aromatic-amino-acid-glyoxylate transaminase activity", "definition": "Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid. [EC:2.6.1.60, MetaCyc:2.6.1.60-RXN]"}
{"concept_id": "C1324968", "aliases": ["asparagine-keto acid aminotransferase activity", "asparagine--oxo-acid aminotransferase activity", "asparagine-oxo-acid aminotransferase activity", "L-asparagine:2-oxo-acid aminotransferase activity"], "types": ["T044"], "canonical_name": "asparagine-oxo-acid transaminase activity", "definition": "Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate. [EC:2.6.1.14, MetaCyc:2.6.1.14-RXN]"}
{"concept_id": "C1324969", "aliases": ["aspartate--phenylpyruvate aminotransferase activity", "aspartate-phenylpyruvate aminotransferase activity", "L-aspartate:phenylpyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "aspartate-phenylpyruvate transaminase activity", "definition": "Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate. [EC:2.6.1.70, RHEA:14097]"}
{"concept_id": "C1324970", "aliases": ["L-alanine:cephalosporin-C aminotransferase activity", "cephalosporin C aminotransferase activity", "cephalosporin-C:2-oxoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "cephalosporin-C transaminase activity", "definition": "Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C. [EC:2.6.1.74, RHEA:14553]"}
{"concept_id": "C1324972", "aliases": ["cysteine conjugate aminotransferase activity", "cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)", "S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "cysteine-conjugate transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate. [EC:2.6.1.75, RHEA:13485]"}
{"concept_id": "C1324973", "aliases": ["D-hydroxyphenylglycine aminotransferase activity", "D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity", "D-4-hydroxyphenylglycine aminotransferase activity"], "types": ["T044"], "canonical_name": "D-4-hydroxyphenylglycine transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate. [EC:2.6.1.72, RHEA:15589]"}
{"concept_id": "C1324975", "aliases": ["D-methionine transaminase activity", "D-methionine--pyruvate aminotransferase activity", "D-methionine-pyruvate aminotransferase activity", "D-methionine aminotransferase activity", "D-methionine:pyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "D-methionine-pyruvate transaminase activity", "definition": "Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine. [EC:2.6.1.41, RHEA:23836]"}
{"concept_id": "C1324976", "aliases": ["diaminobutyrate--pyruvate aminotransferase activity", "L-diaminobutyric acid transaminase activity", "L-2,4-diaminobutanoate:pyruvate aminotransferase activity", "diaminobutyrate-pyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "diaminobutyrate-pyruvate transaminase activity", "definition": "Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde. [EC:2.6.1.46, RHEA:12380]"}
{"concept_id": "C1324977", "aliases": ["L-dopa transaminase activity", "glutamate-DOPP transaminase (GDT)", "aspartate-DOPP transaminase (ADT)", "phenylalanine-DOPP transaminase (PDT)", "DOPA aminotransferase activity", "3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity", "dopa transaminase activity", "dihydroxyphenylalanine aminotransferase activity"], "types": ["T044"], "canonical_name": "dihydroxyphenylalanine transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate. [EC:2.6.1.49, RHEA:15273]"}
{"concept_id": "C1324978", "aliases": ["3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity", "diiodotyrosine aminotransferase activity", "halogenated tyrosine transaminase activity", "halogenated tyrosine aminotransferase activity"], "types": ["T044"], "canonical_name": "diiodotyrosine transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate. [EC:2.6.1.24, RHEA:19781]"}
{"concept_id": "C1324979", "aliases": ["glucosamine-6-phosphate synthase activity", "hexosephosphate aminotransferase activity", "D-fructose-6-phosphate amidotransferase activity", "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)", "glucosamine 6-phosphate synthase activity", "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity", "GlcN6P synthase activity", "glucosamine-6-phosphate isomerase (glutamine-forming) activity", "L-glutamine-D-fructose-6-phosphate amidotransferase activity"], "types": ["T044"], "canonical_name": "glutamine-fructose-6-phosphate transaminase (isomerizing) activity", "definition": "Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. [EC:2.6.1.16, RHEA:13237]"}
{"concept_id": "C1324980", "aliases": ["glutamine-phenylpyruvate aminotransferase activity", "glutamine--phenylpyruvate aminotransferase activity", "L-glutamine:phenylpyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "glutamine-phenylpyruvate transaminase activity", "definition": "Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine. [EC:2.6.1.64, RHEA:17593]"}
{"concept_id": "C1324981", "aliases": ["glutamine--pyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "glutamine-pyruvate transaminase activity"}
{"concept_id": "C1324982", "aliases": ["glutamine-scyllo-inosose aminotransferase activity", "glutamine-scyllo-inosose transaminase activity", "glutamine--scyllo-inosose aminotransferase activity", "L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity", "glutamine--scyllo-inosose transaminase activity", "L-glutamine-keto-scyllo-inositol aminotransferase activity", "glutamine scyllo-inosose aminotransferase activity", "L-glutamine-scyllo-inosose transaminase activity"], "types": ["T044"], "canonical_name": "glutamine-scyllo-inositol transaminase activity", "definition": "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate. [EC:2.6.1.50, RHEA:22920]"}
{"concept_id": "C1324983", "aliases": ["glycine aminotransferase activity"], "types": ["T044"], "canonical_name": "glycine transaminase activity"}
{"concept_id": "C1324984", "aliases": ["glycine--oxaloacetate aminotransferase activity", "glycine:oxaloacetate aminotransferase activity", "glycine-oxaloacetate aminotransferase activity", "glycine-oxalacetate aminotransferase activity"], "types": ["T044"], "canonical_name": "glycine-oxaloacetate transaminase activity", "definition": "Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate. [EC:2.6.1.35, RHEA:17141]"}
{"concept_id": "C1324985", "aliases": ["kynurenine-glyoxylate aminotransferase activity", "kynurenine--glyoxylate aminotransferase activity", "L-kynurenine:glyoxylate aminotransferase (cyclizing)"], "types": ["T044"], "canonical_name": "kynurenine-glyoxylate transaminase activity", "definition": "Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine. [EC:2.6.1.63, RHEA:19249]"}
{"concept_id": "C1324986", "aliases": ["leucine aminotransferase activity"], "types": ["T044"], "canonical_name": "leucine transaminase activity"}
{"concept_id": "C1324987", "aliases": ["Lys-AT", "lysine-pyruvate aminotransferase activity", "lysine--pyruvate 6-aminotransferase activity", "L-lysine:pyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "lysine-pyruvate 6-transaminase activity", "definition": "Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine. [EC:2.6.1.71, RHEA:19393]"}
{"concept_id": "C1324988", "aliases": ["methionine-glyoxylate aminotransferase activity", "L-methionine:glyoxylate aminotransferase activity", "MGAT activity"], "types": ["T044"], "canonical_name": "methionine-glyoxylate transaminase activity", "definition": "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine. [EC:2.6.1.73, RHEA:22884]"}
{"concept_id": "C1324990", "aliases": ["epsilon-acetyl-beta-lysine aminotransferase activity", "6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity", "N(6)-acetyl-beta-lysine aminotransferase activity", "N6-acetyl-beta-lysine aminotransferase activity"], "types": ["T044"], "canonical_name": "N6-acetyl-beta-lysine transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate. [EC:2.6.1.65, MetaCyc:2.6.1.65-RXN]"}
{"concept_id": "C1324991", "aliases": ["ornithine(lysine) aminotransferase activity", "L-ornithine:2-oxoglutarate-aminotransferase activity", "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity", "lysine/ornithine:2-oxoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "ornithine(lysine) transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate. [MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN]"}
{"concept_id": "C1324993", "aliases": ["pyridoxamine--pyruvate aminotransferase activity", "pyridoxamineu-pyruvic transaminase activity", "pyridoxamine-pyruvate aminotransferase activity", "pyridoxamine:pyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "pyridoxamine-pyruvate transaminase activity", "definition": "Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal. [EC:2.6.1.30, RHEA:12841]"}
{"concept_id": "C1324994", "aliases": ["L-serine:glyoxylate aminotransferase activity", "serine--glyoxylate aminotransferase activity", "SGAT activity"], "types": ["T044"], "canonical_name": "serine-glyoxylate transaminase activity", "definition": "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine. [EC:2.6.1.45, MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN]"}
{"concept_id": "C1324995", "aliases": ["taurine aminotransferase activity", "taurine--glutamate transaminase activity", "taurine--alpha-ketoglutarate aminotransferase activity", "taurine:2-oxoglutarate aminotransferase activity", "taurine transaminase activity"], "types": ["T044"], "canonical_name": "taurine-2-oxoglutarate transaminase activity", "definition": "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate. [EC:2.6.1.55, MetaCyc:RXN-2301]"}
{"concept_id": "C1324997", "aliases": ["tryptophan--phenylpyruvate aminotransferase activity", "L-tryptophan:phenylpyruvate aminotransferase activity", "L-tryptophan-alpha-ketoisocaproate aminotransferase activity", "tryptophan-phenylpyruvate aminotransferase activity"], "types": ["T044"], "canonical_name": "tryptophan-phenylpyruvate transaminase activity", "definition": "Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine. [EC:2.6.1.28, RHEA:13741]"}
{"concept_id": "C1324998", "aliases": ["UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity", "uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity", "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity", "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose. [PMID:16286454, RHEA:31663]"}
{"concept_id": "C1324999", "aliases": ["valine--3-methyl-2-oxovalerate aminotransferase activity", "valine-2-keto-methylvalerate aminotransferase activity", "valine-3-methyl-2-oxovalerate aminotransferase activity", "valine--isoleucine transaminase activity", "valine--isoleucine aminotransferase activity", "L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity"], "types": ["T044"], "canonical_name": "valine-3-methyl-2-oxovalerate transaminase activity", "definition": "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine. [EC:2.6.1.32, RHEA:11468]"}
{"concept_id": "C1325000", "aliases": ["dATP(dGTP)--DNA purine transferase activity", "dATP(dGTP):depurinated-DNA purine transferase activity"], "types": ["T044"], "canonical_name": "dATP(dGTP)-DNA purinetransferase activity", "definition": "Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA. [EC:2.6.99.1, MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN]"}
{"concept_id": "C1325001", "aliases": ["3'-hydroxymethylcephem-O-carbamoyltransferase activity", "carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity"], "types": ["T044"], "canonical_name": "3-hydroxymethylcephem carbamoyltransferase activity", "definition": "Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem. [EC:2.1.3.7, MetaCyc:2.1.3.7-RXN]"}
{"concept_id": "C1325002", "aliases": ["lysine transcarbamylase activity", "carbamoyl-phosphate:L-lysine carbamoyltransferase activity"], "types": ["T044"], "canonical_name": "lysine carbamoyltransferase activity", "definition": "Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H(+) + phosphate. [EC:2.1.3.8, RHEA:17121]"}
{"concept_id": "C1325003", "aliases": ["(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity", "methylmalonyl coenzyme A carboxyltransferase activity", "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity", "methylmalonyl-CoA transcarboxylase activity", "(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity", "oxalacetic transcarboxylase activity", "methylmalonyl-CoA carboxyltransferase activity"], "types": ["T044"], "canonical_name": "methylmalonyl-CoA carboxytransferase activity", "definition": "Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA. [EC:2.1.3.1, MetaCyc:2.1.3.1-RXN]"}
{"concept_id": "C1325004", "aliases": ["oxamic transcarbamylase activity", "carbamoyl-phosphate:oxamate carbamoyltransferase activity"], "types": ["T044"], "canonical_name": "oxamate carbamoyltransferase activity", "definition": "Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate. [EC:2.1.3.5, RHEA:22984]"}
{"concept_id": "C1325005", "aliases": ["PTCase activity", "carbamoyl-phosphate:putrescine carbamoyltransferase activity", "putrescine synthase activity", "putrescine transcarbamylase activity"], "types": ["T044"], "canonical_name": "putrescine carbamoyltransferase activity", "definition": "Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H(+) + phosphate. [EC:2.1.3.6, RHEA:21936]"}
{"concept_id": "C1325006", "aliases": ["5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria. [GOC:hjd, ISBN:1555811337]", "canonical_name": "RUMT"}
{"concept_id": "C1325007", "aliases": ["FDTS activity", "flavin dependent thymidylate synthase activity", "Thy1 activity", "5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity", "ThyX activity"], "types": ["T044"], "canonical_name": "thymidylate synthase (FAD) activity", "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+. [EC:2.1.1.148]"}
{"concept_id": "C1325008", "aliases": [], "types": ["T044"], "canonical_name": "5-methyltetrahydrofolate-dependent methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate. [GOC:ai]"}
{"concept_id": "C1325009", "aliases": ["dCMP methyltransferase activity", "5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity", "deoxycytidylate methyltransferase activity"], "types": ["T044"], "canonical_name": "deoxycytidylate C-methyltransferase activity", "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate. [EC:2.1.1.54, RHEA:11568]"}
{"concept_id": "C1325010", "aliases": ["S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity"], "types": ["T044"], "canonical_name": "corydaline synthase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP(+). [EC:2.1.1.147, RHEA:14773]"}
{"concept_id": "C1325011", "aliases": ["5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity", "2-methylserine hydroxymethyltransferase activity", "D-alanine hydroxymethyltransferase activity"], "types": ["T044"], "canonical_name": "D-alanine 2-hydroxymethyltransferase activity", "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine. [EC:2.1.2.7, RHEA:10064]"}
{"concept_id": "C1325012", "aliases": ["dCMP hydroxymethylase activity", "deoxycytidylate hydroxymethyltransferase activity", "5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity", "deoxyCMP hydroxymethylase activity", "deoxycytidylic hydroxymethylase activity", "deoxycytidylate hydroxymethylase activity", "d-cytidine 5'-monophosphate hydroxymethylase activity"], "types": ["T044"], "canonical_name": "deoxycytidylate 5-hydroxymethyltransferase activity", "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate. [EC:2.1.2.8, RHEA:11280]"}
{"concept_id": "C1325013", "aliases": [], "types": ["T044"], "canonical_name": "juvenile hormone acid methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to juvenile hormone acid. [GOC:bf]"}
{"concept_id": "C1325014", "aliases": ["methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity", "methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity", "methyltransferase 1", "MT1", "MtaB", "methanol-corrinoid protein Co-methyltransferase", "methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity", "methanol:corrinoid methyltransferase activity", "methanol cobalamin methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide. [PMID:6438059, RHEA:45204]", "canonical_name": "MT 1"}
{"concept_id": "C1325015", "aliases": ["5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity", "5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity", "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity", "folate-dependent ribothymidyl synthase activity", "methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity"], "types": ["T044"], "canonical_name": "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity", "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+. [EC:2.1.1.74, MetaCyc:2.1.1.74-RXN]"}
{"concept_id": "C1325016", "aliases": ["histone methylase activity (H3-K56 specific)", "histone lysine N-methyltransferase activity (H3-K27 specific)", "histone methylase activity (H3-K27 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-K27 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein. [GOC:ai]"}
{"concept_id": "C1325017", "aliases": ["histone lysine N-methyltransferase activity (H3-K36 specific)", "histone methylase activity (H3-K36 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-K36 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein. [GOC:ai]"}
{"concept_id": "C1325018", "aliases": ["histone methylase activity (H3-K4 specific)", "histone lysine N-methyltransferase activity (H3-K4 specific)", "histone H3 lysine 4-specific methyltransferase activity"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-K4 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. [PMID:12086618]"}
{"concept_id": "C1325019", "aliases": ["histone lysine N-methyltransferase activity (H3-K9 specific)", "histone methylase activity (H3-K9 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-K9 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein. [GOC:ai]"}
{"concept_id": "C1325020", "aliases": ["histone H4 lysine 20-specific methyltransferase activity", "histone methylase activity (H4-K20 specific)", "histone lysine N-methyltransferase activity (H4-K20 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H4-K20 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein. [PMID:12086618]"}
{"concept_id": "C1325021", "aliases": ["N-methylglutamate synthase activity", "methylamine:L-glutamate N-methyltransferase activity", "methylamine-glutamate methyltransferase activity"], "types": ["T044"], "canonical_name": "methylamine-glutamate N-methyltransferase activity", "definition": "Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH(4)(+). [EC:2.1.1.21, RHEA:15837]"}
{"concept_id": "C1325022", "aliases": ["PLMT", "phosphatidyl-N-methylethanolamine methyltransferase activity", "phospholipid methyltransferase activity", "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity", "phosphatidylmonomethylethanolamine methyltransferase activity", "phosphatidyl-N-monomethylethanolamine methyltransferase activity"], "types": ["T044"], "canonical_name": "phosphatidyl-N-methylethanolamine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine. [EC:2.1.1.71]"}
{"concept_id": "C1325023", "aliases": ["trimethylsulfonium-tetrahydrofolate methyltransferase activity", "trimethylsulphonium-tetrahydrofolate N-methyltransferase activity", "trimethylsulfonium:tetrahydrofolate N-methyltransferase activity"], "types": ["T044"], "canonical_name": "trimethylsulfonium-tetrahydrofolate N-methyltransferase activity", "definition": "Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+). [EC:2.1.1.19, RHEA:13693]"}
{"concept_id": "C1325024", "aliases": ["isoeugenol O-methyltransferase activity", "S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity"], "types": ["T044"], "canonical_name": "(iso)eugenol O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol. [EC:2.1.1.146, MetaCyc:2.1.1.146-RXN]"}
{"concept_id": "C1325025", "aliases": ["S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity", "caffeate 3-O-methyltransferase activity", "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity", "caffeate methyltransferase activity"], "types": ["T044"], "canonical_name": "caffeate O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate. [EC:2.1.1.68, MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN]"}
{"concept_id": "C1325026", "aliases": ["demethylsterigmatocystin methyltransferase activity", "S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "demethylsterigmatocystin 6-O-methyltransferase activity", "definition": "Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine. [EC:2.1.1.109, MetaCyc:2.1.1.109-RXN]"}
{"concept_id": "C1325027", "aliases": ["sterigmatocystin methyltransferase activity", "S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity", "sterigmatocystin 8-O-methyltransferase activity", "S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "sterigmatocystin 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine. [EC:2.1.1.110, MetaCyc:2.1.1.110-RXN]"}
{"concept_id": "C1325028", "aliases": ["S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity", "gamma-tocopherol methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol. [EC:2.1.1.95, MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN]", "canonical_name": "tocopherol O-methyltransferase activity"}
{"concept_id": "C1325029", "aliases": [], "types": ["T045"], "canonical_name": "mRNA (N6-adenosine)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U. [GOC:hjd]"}
{"concept_id": "C1325030", "aliases": ["S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity", "rRNA adenosine 2'-methylase activity", "ribosomal ribonucleate adenosine 2'-methyltransferase activity"], "types": ["T045"], "canonical_name": "rRNA (adenosine-2'-O-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine. [EC:2.1.1.230]"}
{"concept_id": "C1325032", "aliases": ["transfer RNA uracil 5-methyltransferase activity", "M5U-methyltransferase activity", "RUMT activity", "tRNA uracil 5-methyltransferase activity", "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity", "tRNA (m5U54) methyltransferase activity", "tRNA:m(5)U54-methyltransferase activity", "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity", "tRNA (uracil-5-)-methyltransferase activity", "RUMT", "transfer RNA uracil methylase activity", "tRNA:m5U54-methyltransferase activity"], "types": ["T045"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes. [GOC:hjd, ISBN:1555811337]", "canonical_name": "S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity"}
{"concept_id": "C1325033", "aliases": ["S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity", "norreticuline N-methyltransferase activity", "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity"], "types": ["T044"], "canonical_name": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline. [EC:2.1.1.115]"}
{"concept_id": "C1325034", "aliases": ["S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "(RS)-norcoclaurine 6-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine. [EC:2.1.1.128]"}
{"concept_id": "C1325035", "aliases": ["S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity"], "types": ["T044"], "canonical_name": "(S)-coclaurine-N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine. [EC:2.1.1.140]"}
{"concept_id": "C1325036", "aliases": ["S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity", "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "(S)-scoulerine 9-O-methyltransferase activity", "definition": "Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.117, RHEA:23808]"}
{"concept_id": "C1325037", "aliases": ["S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity", "tetrahydroprotoberberine cis-N-methyltransferase activity"], "types": ["T044"], "canonical_name": "(S)-tetrahydroprotoberberine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine. [EC:2.1.1.122]"}
{"concept_id": "C1325038", "aliases": ["S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "10-hydroxydihydrosanguinarine 10-O-methyltransferase activity", "definition": "Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+). [EC:2.1.1.119, RHEA:18541]"}
{"concept_id": "C1325039", "aliases": ["11-demethyl-17-deacetylvindoline 11-methyltransferase activity", "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity", "tabersonine 16-O-methyltransferase activity", "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline. [EC:2.1.1.94]"}
{"concept_id": "C1325040", "aliases": ["S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "12-hydroxydihydrochelirubine 12-O-methyltransferase activity", "definition": "Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+). [EC:2.1.1.120, RHEA:21092]"}
{"concept_id": "C1325041", "aliases": ["16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity", "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity", "NMT activity", "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity", "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity"], "types": ["T044"], "canonical_name": "16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity", "definition": "Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+). [EC:2.1.1.99, RHEA:11336]"}
{"concept_id": "C1325042", "aliases": ["24-methylenelophenol C-241-methyltransferase activity", "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity", "SMT2", "24-methylenelophenol C-24(1)-methyltransferase activity"], "types": ["T044"], "canonical_name": "24-methylenesterol C-methyltransferase activity", "definition": "Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.143, RHEA:21044]"}
{"concept_id": "C1325043", "aliases": ["S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity", "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity", "staurosporine synthase activity"], "types": ["T044"], "canonical_name": "3'-demethylstaurosporine O-methyltransferase activity", "definition": "Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine. [EC:2.1.1.139, RHEA:11696]"}
{"concept_id": "C1325044", "aliases": ["S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline. [EC:2.1.1.116]"}
{"concept_id": "C1325045", "aliases": ["3,7-dimethylquercetin 4'-O-methyltransferase activity", "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity", "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "3,7-dimethylquercitin 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.83, RHEA:21832]"}
{"concept_id": "C1325046", "aliases": ["S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity", "3-hydroxyanthranilate 4-methyltransferase activity"], "types": ["T044"], "canonical_name": "3-hydroxyanthranilate 4-C-methyltransferase activity", "definition": "Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.97, RHEA:17833]"}
{"concept_id": "C1325047", "aliases": ["S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity", "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity", "3-methylquercetin 7-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "3-methylquercitin 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine. [EC:2.1.1.82, RHEA:16181]"}
{"concept_id": "C1325048", "aliases": ["S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity", "bergaptol O-methyltransferase activity", "furanocoumarin 5-O-methyltransferase activity", "BMT activity", "furanocoumarin 5-methyltransferase activity", "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity", "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity", "bergaptol methyltransferase activity", "bergaptol 5-O-methyltransferase activity", "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity"], "types": ["T044"], "canonical_name": "5-hydroxyfuranocoumarin 5-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin. [EC:2.1.1.69]"}
{"concept_id": "C1325049", "aliases": ["6-hydroxymellein methyltransferase activity", "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "6-hydroxymellein O-methyltransferase activity", "definition": "Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.108, RHEA:15201]"}
{"concept_id": "C1325050", "aliases": ["S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "6-O-methylnorlaudanosoline 5'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline. [EC:2.1.1.121]"}
{"concept_id": "C1325051", "aliases": ["S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity", "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity", "XMT activity", "furanocoumarin 8-O-methyl-transferase activity", "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity", "xanthotoxol O-methyltransferase activity", "xanthotoxol methyltransferase activity", "xanthotoxol 8-O-methyltransferase activity", "furanocoumarin 8-methyltransferase activity"], "types": ["T044"], "canonical_name": "8-hydroxyfuranocoumarin 8-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin. [EC:2.1.1.70]"}
{"concept_id": "C1325052", "aliases": ["8-hydroxyquercetin 8-O-methyltransferase activity", "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity", "flavonol 8-methyltransferase activity"], "types": ["T044"], "canonical_name": "8-hydroxyquercitin 8-O-methyltransferase activity", "definition": "Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.88, RHEA:16593]"}
{"concept_id": "C1325053", "aliases": ["S-adenosyl-L-methionine:amine N-methyltransferase activity"], "types": ["T044"], "canonical_name": "amine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. [EC:2.1.1.49]"}
{"concept_id": "C1325054", "aliases": ["S-adenosyl-L-methionine:anthranilate N-methyltransferase activity", "anthranilic acid N-methyltransferase activity"], "types": ["T044"], "canonical_name": "anthranilate N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.111, RHEA:12180]"}
{"concept_id": "C1325055", "aliases": ["S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity", "flavonoid methyltransferase activity"], "types": ["T044"], "canonical_name": "apigenin 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone. [EC:2.1.1.75]"}
{"concept_id": "C1325056", "aliases": ["S-adenosyl-L-methionine:arsenite As-methyltransferase activity", "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity", "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity"], "types": ["T044"], "canonical_name": "arsenite methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate. [EC:2.1.1.137]"}
{"concept_id": "C1325058", "aliases": ["S-adenosyl-L-methionine:carnosine N-methyltransferase activity"], "types": ["T044"], "canonical_name": "carnosine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+). [EC:2.1.1.22, RHEA:14205]"}
{"concept_id": "C1325059", "aliases": ["S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity", "trichlorophenol O-methyltransferase activity"], "types": ["T044"], "canonical_name": "chlorophenol O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole. [EC:2.1.1.136]"}
{"concept_id": "C1325060", "aliases": ["S-adenosyl-L-methionine:columbamine O-methyltransferase activity"], "types": ["T044"], "canonical_name": "columbamine O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine. [EC:2.1.1.118, RHEA:15373]"}
{"concept_id": "C1325061", "aliases": ["S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity"], "types": ["T044"], "canonical_name": "cycloartenol 24-C-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.142, RHEA:13137]"}
{"concept_id": "C1325062", "aliases": ["S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity", "demethylmacrocin methyltransferase activity"], "types": ["T044"], "canonical_name": "demethylmacrocin O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin. [EC:2.1.1.102, RHEA:17573]"}
{"concept_id": "C1325063", "aliases": ["dimethylhistidine methyltransferase activity", "S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity", "S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity"], "types": ["T044"], "canonical_name": "dimethylhistidine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine. [EC:2.1.1.44]"}
{"concept_id": "C1325065", "aliases": ["S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "glucuronoxylan 4-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate. [EC:2.1.1.112]"}
{"concept_id": "C1325066", "aliases": ["S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity", "methionine-guanidinoacetic transmethylase activity", "guanidinoacetate transmethylase activity", "guanidinoacetate methyltransferase activity", "GA methylpherase activity", "guanidoacetate methyltransferase activity"], "types": ["T044"], "canonical_name": "guanidinoacetate N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+). [EC:2.1.1.2, RHEA:10656]"}
{"concept_id": "C1325067", "aliases": ["indolepyruvate 3-methyltransferase activity", "indolepyruvate methyltransferase activity", "indolepyruvic acid methyltransferase activity", "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity", "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity"], "types": ["T044"], "canonical_name": "indolepyruvate C-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate. [EC:2.1.1.47]"}
{"concept_id": "C1325068", "aliases": ["inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)", "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity", "inositol D-1-methyltransferase activity", "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "inositol 1-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.40, RHEA:17565]"}
{"concept_id": "C1325069", "aliases": ["myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)", "inositol L-1-methyltransferase activity", "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity", "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity", "S-adenosylmethionine:myo-inositol 1-methyltransferase activity"], "types": ["T044"], "canonical_name": "inositol 3-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.39, RHEA:18877]"}
{"concept_id": "C1325070", "aliases": ["myo-inositol 4-O-methyltransferase activity", "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity", "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity"], "types": ["T044"], "canonical_name": "inositol 4-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.129, RHEA:23248]"}
{"concept_id": "C1325071", "aliases": ["S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity"], "types": ["T044"], "canonical_name": "iodophenol O-methyltransferase activity", "definition": "Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.26, RHEA:14313]"}
{"concept_id": "C1325072", "aliases": ["aldoxime methyltransferase activity", "aldoxime O-methyltransferase activity", "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity", "S-adenosylmethionine:aldoxime O-methyltransferase activity"], "types": ["T044"], "canonical_name": "isobutyraldoxime O-methyltransferase activity", "definition": "Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.91, RHEA:10996]"}
{"concept_id": "C1325073", "aliases": ["isoflavone O-methyltransferase activity", "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity", "4'-hydroxyisoflavone methyltransferase activity", "isoflavone methyltransferase activity"], "types": ["T044"], "canonical_name": "isoflavone 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone. [EC:2.1.1.46]"}
{"concept_id": "C1325074", "aliases": ["isoorientin 3'-methyltransferase activity", "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "isoorientin 3'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin. [EC:2.1.1.78, RHEA:24096]"}
{"concept_id": "C1325075", "aliases": ["jasmonic acid carboxyl methyltransferase activity", "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity", "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity"], "types": ["T044"], "canonical_name": "methyl jasmonate methylesterase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonate = S-adenosyl-L-homocysteine + a methyljasmonate. [RHEA:13349]"}
{"concept_id": "C1325076", "aliases": ["S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "licodione 2'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.65, RHEA:18521]"}
{"concept_id": "C1325077", "aliases": ["loganate methyltransferase activity", "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity", "S-adenosyl-L-methionine:loganic acid methyltransferase activity"], "types": ["T044"], "canonical_name": "loganate O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin. [EC:2.1.1.50]"}
{"concept_id": "C1325078", "aliases": ["S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity", "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity", "luteolin methyltransferase activity", "luteolin 3'-O-methyltransferase activity", "o-dihydric phenol meta-O-methyltransferase activity", "o-dihydric phenol methyltransferase activity", "o-diphenol m-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "luteolin O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.42, RHEA:14589]"}
{"concept_id": "C1325079", "aliases": ["S-adenosyl-L-methionine-macrocin O-methyltransferase activity", "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity", "macrocin methyltransferase activity"], "types": ["T044"], "canonical_name": "macrocin O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin. [EC:2.1.1.101, RHEA:17269]"}
{"concept_id": "C1325080", "aliases": ["S-adenosylmethionine-methionine methyltransferase activity", "S-adenosylmethionine transmethylase activity", "S-adenosyl methionine:methionine methyl transferase activity", "methionine methyltransferase activity", "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity"], "types": ["T044"], "canonical_name": "methionine S-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine. [EC:2.1.1.12]"}
{"concept_id": "C1325081", "aliases": [], "types": ["T044"], "canonical_name": "methylarsonite methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate. [EC:2.1.1.138]"}
{"concept_id": "C1325082", "aliases": ["S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity", "flavonol 6-methyltransferase activity", "6-OMT"], "types": ["T044"], "canonical_name": "methylquercetagetin 6-O-methyltransferase activity", "definition": "Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.84, RHEA:18717]"}
{"concept_id": "C1325083", "aliases": ["S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity", "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity"], "types": ["T044"], "canonical_name": "N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity", "definition": "Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.105, RHEA:17405]"}
{"concept_id": "C1325084", "aliases": ["S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity", "O-demethylpuromycin methyltransferase activity"], "types": ["T044"], "canonical_name": "O-demethylpuromycin O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin. [EC:2.1.1.38]"}
{"concept_id": "C1325085", "aliases": ["S-adenosyl-L-methionine:phenol O-methyltransferase activity", "PMT"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+). [EC:2.1.1.25, RHEA:14809]", "canonical_name": "phenol O-methyltransferase activity"}
{"concept_id": "C1325086", "aliases": ["polysaccharide methyltransferase activity", "acylpolysacharide 6-methyltransferase activity", "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "polysaccharide O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units. [EC:2.1.1.18]"}
{"concept_id": "C1325087", "aliases": ["S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity", "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity"], "types": ["T044"], "canonical_name": "precorrin-2 C20-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A. [EC:2.1.1.130, RHEA:16841]"}
{"concept_id": "C1325088", "aliases": ["precorrin-3 methyltransferase activity", "CobJ", "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity", "precorrin-3 methylase activity"], "types": ["T044"], "canonical_name": "precorrin-3B C17-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4. [EC:2.1.1.131]"}
{"concept_id": "C1325089", "aliases": ["S-adenosyl-L-methionine:putrescine N-methyltransferase activity", "putrescine methyltransferase activity"], "types": ["T044"], "canonical_name": "putrescine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.53, RHEA:15037]"}
{"concept_id": "C1325090", "aliases": ["S-adenosyl-L-methionine:pyridine N-methyltransferase activity", "pyridine methyltransferase activity"], "types": ["T044"], "canonical_name": "pyridine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine. [EC:2.1.1.87, RHEA:16893]"}
{"concept_id": "C1325091", "aliases": ["flavonoid 3-methyltransferase activity", "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "quercetin 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone. [EC:2.1.1.76]"}
{"concept_id": "C1325092", "aliases": ["S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity", "tetrahydrocolumbamine methyltransferase activity"], "types": ["T044"], "canonical_name": "tetrahydrocolumbamine 2-O-methyltransferase activity", "definition": "Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine. [EC:2.1.1.89, RHEA:22536]"}
{"concept_id": "C1325093", "aliases": ["S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "trans-aconitate 2-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine. [EC:2.1.1.144, RHEA:14969]"}
{"concept_id": "C1325094", "aliases": ["tryptophan 2-methyltransferase activity", "S-adenosylmethionine:tryptophan 2-methyltransferase activity", "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity"], "types": ["T044"], "canonical_name": "tryptophan 2-C-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+). [EC:2.1.1.106, RHEA:17321]"}
{"concept_id": "C1325095", "aliases": ["S-adenosyl-L-methionine:tyramine N-methyltransferase activity", "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)", "tyramine methylpherase activity", "S-adenosyl-methionine:tyramine N-methyltransferase activity"], "types": ["T044"], "canonical_name": "tyramine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.27, RHEA:14865]"}
{"concept_id": "C1325097", "aliases": ["S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity", "cytochrome c-methionine S-methyltransferase activity"], "types": ["T044"], "canonical_name": "[cytochrome c]-methionine S-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine. [EC:2.1.1.123]"}
{"concept_id": "C1325098", "aliases": ["S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity", "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity", "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity", "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity", "RuBisCO LSMT activity", "RuBisCO methyltransferase activity", "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity"], "types": ["T044"], "canonical_name": "[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine. [EC:2.1.1.127]"}
{"concept_id": "C1325099", "aliases": ["betaine-homocysteine transmethylase activity", "betaine-homocysteine methyltransferase activity", "trimethylammonioacetate:L-homocysteine S-methyltransferase activity"], "types": ["T044"], "canonical_name": "betaine-homocysteine S-methyltransferase activity", "definition": "Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine. [EC:2.1.1.5, RHEA:22336]"}
{"concept_id": "C1325100", "aliases": ["dimethylthetin-homocysteine methyltransferase activity", "dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity", "thetin-homocysteine methylpherase activity"], "types": ["T044"], "canonical_name": "thetin-homocysteine S-methyltransferase activity", "definition": "Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H(+). [EC:2.1.1.3, RHEA:22788]"}
{"concept_id": "C1325101", "aliases": ["nucleotide pyrophosphokinase activity", "ATP:nucleoside-5'-phosphate diphosphotransferase activity", "nucleotide 3'-pyrophosphokinase activity", "ATP nucleotide 3'-pyrophosphokinase activity", "ATP:nucleotide pyrophosphotransferase activity"], "types": ["T044"], "canonical_name": "nucleotide diphosphokinase activity", "definition": "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate. [EC:2.7.6.4, MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN]"}
{"concept_id": "C1325102", "aliases": ["MEP cytidylyltransferase activity", "4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity", "CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity", "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity"], "types": ["T044"], "canonical_name": "2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity", "definition": "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate. [EC:2.7.7.60, RHEA:13429]"}
{"concept_id": "C1325103", "aliases": ["APSAT", "adenylylsulfate:ammonia adenylyltransferase activity", "adenylylsulphate-ammonia adenylyltransferase activity"], "types": ["T044"], "canonical_name": "adenylylsulfate-ammonia adenylyltransferase activity", "definition": "Catalysis of the reaction: 5'-adenylyl sulfate + NH(4)(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate. [EC:2.7.7.51, RHEA:19197]"}
{"concept_id": "C1325104", "aliases": ["ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity", "adenosine diphosphate glucose:orthophosphate adenylyltransferase activity", "adenosine diphosphosugar phosphorylase activity", "ADP sugar phosphorylase activity", "ADP:aldose-1-phosphate adenylyltransferase activity", "ADP-sugar phosphorylase activity", "ADPaldose phosphorylase activity", "ADP-aldose phosphorylase activity"], "types": ["T044"], "canonical_name": "aldose-1-phosphate adenylyltransferase activity", "definition": "Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose. [EC:2.7.7.36, MetaCyc:2.7.7.36-RXN]"}
{"concept_id": "C1325105", "aliases": ["NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity", "nucleoside diphosphosugar phosphorylase activity", "NDP-aldose phosphorylase activity", "NDP sugar phosphorylase activity", "NDP-sugar phosphorylase activity", "glucose 1-phosphate inosityltransferase activity", "sugar nucleotide phosphorylase activity", "sugar phosphate nucleotidyltransferase activity", "NDP:aldose-1-phosphate nucleotidyltransferase activity", "NDPaldose phosphorylase activity", "nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity"], "types": ["T044"], "canonical_name": "aldose-1-phosphate nucleotidyltransferase activity", "definition": "Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose. [EC:2.7.7.37, MetaCyc:2.7.7.37-RXN]"}
{"concept_id": "C1325106", "aliases": ["ATP:anthranilate adenylyltransferase activity", "ATP:anthranilate N-adenylyltransferase activity", "anthranilic acid adenylyltransferase activity"], "types": ["T044"], "canonical_name": "anthranilate adenylyltransferase activity", "definition": "Catalysis of the reaction: anthranilate + ATP = N-adenylylanthranilate + diphosphate + H(+). [PMID:2995633, RHEA:35091]"}
{"concept_id": "C1325107", "aliases": ["CTP:D-ribitol-5-phosphate cytidylyltransferase activity", "cytidine diphosphoribitol pyrophosphorylase activity", "CDP-ribitol diphosphorylase activity", "cytidine diphosphate ribitol pyrophosphorylase activity", "CDP ribitol pyrophosphorylase activity", "ribitol 5-phosphate cytidylyltransferase activity", "CDP-ribitol pyrophosphorylase activity"], "types": ["T044"], "canonical_name": "D-ribitol-5-phosphate cytidylyltransferase activity", "definition": "Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate. [EC:2.7.7.40, RHEA:12456]"}
{"concept_id": "C1325108", "aliases": ["guanosine diphosphate L-fucose pyrophosphorylase activity", "GDP-fucose diphosphorylase activity", "GDP-L-fucose pyrophosphorylase activity", "GDP fucose pyrophosphorylase activity", "GTP:L-fucose-1-phosphate guanylyltransferase activity", "GDP-fucose pyrophosphorylase activity", "GTP:fucose-1-phosphate guanylyltransferase activity", "GTP:beta-L-fucose-1-phosphate guanylyltransferase activity"], "types": ["T044"], "canonical_name": "fucose-1-phosphate guanylyltransferase activity", "definition": "Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose. [EC:2.7.7.30, RHEA:13549]"}
{"concept_id": "C1325109", "aliases": ["dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity", "dTDP galactose pyrophosphorylase activity", "dTDP-galactose pyrophosphorylase activity", "thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity", "dTDP-galactose diphosphorylase activity", "thymidine diphosphogalactose pyrophosphorylase activity", "galactose 1-phosphate thymidylyl transferase activity"], "types": ["T044"], "canonical_name": "galactose-1-phosphate thymidylyltransferase activity", "definition": "Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose. [EC:2.7.7.32, RHEA:17165]"}
{"concept_id": "C1325110", "aliases": ["cytidine diphosphate-D-glucose pyrophosphorylase activity", "cytidine diphosphoglucose pyrophosphorylase activity", "CTP:glucose-1-phosphate cytidylyltransferase activity", "CTP:D-glucose-1-phosphate cytidylyltransferase activity", "cytidine diphosphate glucose pyrophosphorylase activity", "CDP glucose pyrophosphorylase activity", "CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity", "CDP-glucose diphosphorylase activity", "CDP-glucose pyrophosphorylase activity"], "types": ["T044"], "canonical_name": "glucose-1-phosphate cytidylyltransferase activity", "definition": "Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate. [EC:2.7.7.33, RHEA:18213]"}
{"concept_id": "C1325111", "aliases": ["GDP-glucose diphosphorylase activity", "GTP:glucose-1-phosphate guanylyltransferase activity", "GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity", "guanosine diphosphoglucose pyrophosphorylase activity", "GDP-glucose pyrophosphorylase activity", "GDP glucose pyrophosphorylase activity"], "types": ["T044"], "canonical_name": "glucose-1-phosphate guanylyltransferase activity", "definition": "Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose. [EC:2.7.7.34, RHEA:10708]"}
{"concept_id": "C1325112", "aliases": ["UDP-glucuronic acid pyrophosphorylase activity", "UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity", "UTP:glucuronate-1-phosphate uridylyltransferase activity", "UDP-D-glucuronic acid pyrophosphorylase activity", "UDP-glucuronate pyrophosphorylase activity", "uridine diphosphoglucuronic pyrophosphorylase activity"], "types": ["T044"], "canonical_name": "glucuronate-1-phosphate uridylyltransferase activity", "definition": "Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate. [EC:2.7.7.44, RHEA:16325]"}
{"concept_id": "C1325113", "aliases": ["CDP-glycerol diphosphorylase activity", "CTP:glycerol-3-phosphate cytidylyltransferase activity", "CTP:sn-glycerol-3-phosphate cytidylyltransferase activity", "cytidine diphosphoglycerol pyrophosphorylase activity", "CTP:glycerol 3-phosphate cytidylyltransferase activity", "cytidine diphosphate glycerol pyrophosphorylase activity", "CDP-glycerol pyrophosphorylase activity"], "types": ["T044"], "canonical_name": "glycerol-3-phosphate cytidylyltransferase activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate. [EC:2.7.7.39, RHEA:13361]"}
{"concept_id": "C1325114", "aliases": [], "types": ["T044"], "canonical_name": "guanosine-triphosphate guanylyltransferase activity", "definition": "Catalysis of the reaction: 2 GTP = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H(+). [EC:2.7.7.45, RHEA:18153]"}
{"concept_id": "C1325117", "aliases": ["monomethylethanolamine phosphate cytidylyltransferase activity", "CTP:N-methylphosphoethanolamine cytidylyltransferase activity", "CTP:N-methylethanolamine-phosphate cytidylyltransferase activity", "CTP:P-MEA cytidylyltransferase activity"], "types": ["T044"], "canonical_name": "N-methylphosphoethanolamine cytidylyltransferase activity", "definition": "Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate. [EC:2.7.7.57, RHEA:10576]"}
{"concept_id": "C1325118", "aliases": ["NDP-hexose pyrophosphorylase activity", "hexose 1-phosphate guanylyltransferase activity", "NDP hexose pyrophosphorylase activity", "NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity", "NDP-hexose diphosphorylase activity", "nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity", "nucleoside diphosphohexose pyrophosphorylase activity", "hexose 1-phosphate nucleotidyltransferase activity", "NTP:hexose-1-phosphate nucleotidyltransferase activity", "hexose-1-phosphate guanylyltransferase activity", "hexose nucleotidylating enzyme activity"], "types": ["T044"], "canonical_name": "nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity", "definition": "Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate. [EC:2.7.7.28, MetaCyc:2.7.7.28-RXN]"}
{"concept_id": "C1325119", "aliases": ["ATP:phenylalanine adenylyltransferase activity", "L-phenylalanine adenylyltransferase activity", "ATP:L-phenylalanine adenylyltransferase activity"], "types": ["T044"], "canonical_name": "phenylalanine adenylyltransferase activity", "definition": "Catalysis of the reaction: L-phenylalanine + ATP = N-adenylyl-L-phenylalanine + diphosphate + 2 H(+). [EC:2.7.7.54, RHEA:17189]"}
{"concept_id": "C1325120", "aliases": ["ADP:ribose-5-phosphate adenylyltransferase activity", "ADP:D-ribose-5-phosphate adenylyltransferase activity", "ADP ribose phosphorylase activity", "ADP-ribose phosphorylase activity", "adenosine diphosphoribose phosphorylase activity"], "types": ["T044"], "canonical_name": "ribose-5-phosphate adenylyltransferase activity", "definition": "Catalysis of the reaction: D-ribose 5-phosphate + ADP + H(+) = ADP-ribose + phosphate. [EC:2.7.7.35, RHEA:14529]"}
{"concept_id": "C1325121", "aliases": ["TUT activity", "poly(U) polymerase activity", "terminal uridylyltransferase activity", "polynucleotide uridylyltransferase activity", "UTP:RNA uridylyltransferase activity"], "types": ["T044"], "canonical_name": "RNA uridylyltransferase activity", "definition": "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1). [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN]"}
{"concept_id": "C1325122", "aliases": ["xylose-1-phosphate uridylyltransferase activity", "UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity", "uridine diphosphoxylose pyrophosphorylase activity", "xylose 1-phosphate uridylyltransferase activity", "UDP-xylose pyrophosphorylase activity", "uridylyltransferase, xylose 1-phosphate", "UTP-xylose-1-phosphate uridylyltransferase activity"], "types": ["T044"], "canonical_name": "UTP:xylose-1-phosphate uridylyltransferase activity", "definition": "Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate. [EC:2.7.7.11, MetaCyc:2.7.7.11-RXN]"}
{"concept_id": "C1325123", "aliases": ["CDP-ME kinase activity", "4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity", "4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity", "ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity"], "types": ["T044"], "canonical_name": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity", "definition": "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H(+). [EC:2.7.1.148, RHEA:18437]"}
{"concept_id": "C1325124", "aliases": ["5-keto-2-deoxyglucono kinase (phosphorylating)", "ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity", "DKH kinase activity", "5-keto-2-deoxygluconokinase activity"], "types": ["T044"], "canonical_name": "5-dehydro-2-deoxygluconokinase activity", "definition": "Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. [EC:2.7.1.92, MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN]"}
{"concept_id": "C1325125", "aliases": ["acyl-phosphate:D-hexose phosphotransferase activity", "hexose phosphate:hexose phosphotransferase activity"], "types": ["T044"], "canonical_name": "acyl-phosphate-hexose phosphotransferase activity", "definition": "Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid. [EC:2.7.1.61, MetaCyc:2.7.1.61-RXN]"}
{"concept_id": "C1325126", "aliases": ["monoacylglycerol kinase (phosphorylating)", "ATP:acylglycerol 3-phosphotransferase activity", "MGK", "monoacylglycerol kinase activity", "sn-2-monoacylglycerol kinase activity", "monoglyceride kinase activity", "monoglyceride phosphokinase activity"], "types": ["T044"], "canonical_name": "acylglycerol kinase activity", "definition": "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate. [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN]"}
{"concept_id": "C1325127", "aliases": ["ADP:dThd phosphotransferase activity", "adenosine diphosphate-thymidine phosphotransferase activity", "ADP:thymidine 5'-phosphotransferase activity"], "types": ["T044"], "canonical_name": "ADP-thymidine kinase activity", "definition": "Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate. [EC:2.7.1.118, MetaCyc:ADP--THYMIDINE-KINASE-RXN]"}
{"concept_id": "C1325128", "aliases": ["ATP:1-alkyl-sn-glycerol phosphotransferase activity", "alkylglycerol phosphotransferase activity", "ATP-alkylglycerol phosphotransferase activity", "ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity", "1-alkylglycerol kinase (phosphorylating)"], "types": ["T044"], "canonical_name": "alkylglycerol kinase activity", "definition": "Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H(+). [EC:2.7.1.93, RHEA:16937]"}
{"concept_id": "C1325129", "aliases": ["alkyldihydroxyacetone kinase (phosphorylating)", "ATP:O-alkylglycerone phosphotransferase activity", "alkyldihydroxyacetone kinase activity"], "types": ["T044"], "canonical_name": "alkylglycerone kinase activity", "definition": "Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H(+). [EC:2.7.1.84, RHEA:23088]"}
{"concept_id": "C1325130", "aliases": ["thymidine phosphotransferase activity", "adenylic acid:deoxythymidine 5'-phosphotransferase activity", "adenylate-nucleoside phosphotransferase activity", "AMP:thymidine 5'-phosphotransferase activity", "AMP:deoxythymidine kinase activity", "AMP:dThd kinase activity", "AMP:deoxythymidine 5'-phosphotransferase activity"], "types": ["T044"], "canonical_name": "AMP-thymidine kinase activity", "definition": "Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate. [EC:2.7.1.114, MetaCyc:AMP--THYMIDINE-KINASE-RXN]"}
{"concept_id": "C1325131", "aliases": ["STK15", "BARK1", "ADRBK1", "beta-adrenergic-receptor kinase (phosphorylating) activity", "GRK3", "beta-adrenoceptor kinase activity", "beta-AR kinase activity", "beta-ARK", "beta-adrenergic receptor-specific kinase activity", "beta-receptor kinase activity", "beta-adrenergic-receptor kinase activity", "[b-adrenergic-receptor] kinase activity", "beta-adrenergic receptor kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor. [EC:2.7.11.15, MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN]", "canonical_name": "GRK2"}
{"concept_id": "C1325132", "aliases": ["beta-D-glucoside kinase (phosphorylating)", "ATP:cellobiose 6-phosphotransferase activity", "b-glucoside kinase activity"], "types": ["T044"], "canonical_name": "beta-glucoside kinase activity", "definition": "Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose. [EC:2.7.1.85, MetaCyc:BETA-GLUCOSIDE-KINASE-RXN]"}
{"concept_id": "C1325134", "aliases": ["D-arabinokinase (phosphorylating)", "ATP:D-arabinose 5-phosphotransferase activity"], "types": ["T044"], "canonical_name": "D-arabinokinase activity", "definition": "Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP. [EC:2.7.1.54, RHEA:24588]"}
{"concept_id": "C1325135", "aliases": ["dehydogluconokinase activity", "ATP:2-dehydro-D-gluconate 6-phosphotransferase activity", "ketogluconokinase (phosphorylating)", "ketogluconokinase activity", "2-ketogluconokinase activity", "2-ketogluconate kinase activity"], "types": ["T044"], "canonical_name": "dehydrogluconokinase activity", "definition": "Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H(+). [EC:2.7.1.13, RHEA:10788]"}
{"concept_id": "C1325136", "aliases": ["STK30", "AMP-activated kinase activity", "dephospho-reductase kinase kinase activity", "ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity", "dephospho-[reductase kinase] kinase activity", "hydroxymethylglutaryl coenzyme A reductase kinase kinase activity", "reductase kinase kinase activity", "hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]. [EC:2.7.11.3, MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN]", "canonical_name": "AMP-activated protein kinase kinase activity"}
{"concept_id": "C1325137", "aliases": ["dihydrostreptomycin-6-phosphate 3'alpha-kinase activity", "dihydrostreptomycin 6-phosphate kinase (phosphorylating)", "ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity", "ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity"], "types": ["T044"], "canonical_name": "dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity", "definition": "Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H(+). [EC:2.7.1.88, RHEA:16281]"}
{"concept_id": "C1325138", "aliases": ["pyrophosphate-dependent phosphofructo-1-kinase activity", "6-phosphofructokinase (diphosphate) activity", "diphosphate-dependent 6-phosphofructose-1-kinase activity", "inorganic pyrophosphate-phosphofructokinase activity", "diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity", "inorganic pyrophosphate-dependent phosphofructokinase activity", "6-phosphofructokinase (pyrophosphate) activity", "pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity", "pyrophosphate-fructose 6-phosphate phosphotransferase activity", "pyrophosphate-dependent 6-phosphofructose-1-kinase activity"], "types": ["T044"], "canonical_name": "diphosphate-fructose-6-phosphate 1-phosphotransferase activity", "definition": "Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate. [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN]"}
{"concept_id": "C1325139", "aliases": ["PPi-glycerol phosphotransferase activity", "diphosphate:glycerol 1-phosphotransferase activity", "pyrophosphate--glycerol phosphotransferase activity"], "types": ["T044"], "canonical_name": "diphosphate-glycerol phosphotransferase activity", "definition": "Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H(+) + phosphate. [EC:2.7.1.79, RHEA:13689]"}
{"concept_id": "C1325140", "aliases": ["pyrophosphate-protein phosphotransferase activity", "pyrophosphate:protein phosphotransferase activity", "triphosphate-protein phosphotransferase activity", "DiPPT", "triphosphate:microsomal-membrane-protein phosphotransferase activity"], "types": ["T044"], "canonical_name": "diphosphate-protein phosphotransferase activity", "definition": "Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein. [EC:2.7.99.1, MetaCyc:2.7.99.1-RXN]"}
{"concept_id": "C1325141", "aliases": ["diphosphate:L-serine O-phosphotransferase activity", "pyrophosphate--serine phosphotransferase activity", "pyrophosphate-L-serine phosphotransferase activity"], "types": ["T044"], "canonical_name": "diphosphate-serine phosphotransferase activity", "definition": "Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H(+) + phosphate. [EC:2.7.1.80, RHEA:23764]"}
{"concept_id": "C1325142", "aliases": ["ATP:erythritol 4-phosphotransferase activity", "erythritol kinase (phosphorylating)"], "types": ["T044"], "canonical_name": "erythritol kinase activity", "definition": "Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H(+). [EC:2.7.1.27, RHEA:20708]"}
{"concept_id": "C1325143", "aliases": ["ATP:6-deoxy-L-galactose 1-phosphotransferase activity", "fucose kinase activity", "L-fucokinase activity", "ATP:beta-L-fucose 1-phosphotransferase activity", "fucokinase (phosphorylating) activity", "L-fucose kinase activity"], "types": ["T044"], "canonical_name": "fucokinase activity", "definition": "Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+). [EC:2.7.1.52, RHEA:13241]"}
{"concept_id": "C1325144", "aliases": ["ATP:D-galacturonate 1-phosphotransferase activity", "galacturonokinase (phosphorylating) D-galacturonic acid kinase activity"], "types": ["T044"], "canonical_name": "galacturonokinase activity", "definition": "Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H(+). [EC:2.7.1.44, RHEA:12965]"}
{"concept_id": "C1325145", "aliases": ["glucosamine kinase (phosphorylating)", "ATP:D-glucosamine phosphotransferase activity", "aminodeoxyglucose kinase activity", "ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity"], "types": ["T044"], "canonical_name": "glucosamine kinase activity", "definition": "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate. [EC:2.7.1.8, MetaCyc:GLUCOSAMINE-KINASE-RXN]"}
{"concept_id": "C1325146", "aliases": ["glucose-1,6-bisphosphate synthetase activity", "glucose 1,6-diphosphate synthase activity", "3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity", "3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity"], "types": ["T044"], "canonical_name": "glucose-1,6-bisphosphate synthase activity", "definition": "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H(+). [EC:2.7.1.106, RHEA:16769]"}
{"concept_id": "C1325147", "aliases": ["glucose 1-phosphate transphosphorylase activity", "phosphodismutase activity", "D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity"], "types": ["T044"], "canonical_name": "glucose-1-phosphate phosphodismutase activity", "definition": "Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate. [EC:2.7.1.41, MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN]"}
{"concept_id": "C1325148", "aliases": ["glucuronokinase (phosphorylating)", "glucurono-glucuronokinase activity", "ATP:D-glucuronate 1-phosphotransferase activity"], "types": ["T044"], "canonical_name": "glucuronokinase activity", "definition": "Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H(+). [EC:2.7.1.43, RHEA:17005]"}
{"concept_id": "C1325149", "aliases": ["sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity"], "types": ["T044"], "canonical_name": "glycerol-3-phosphate-glucose phosphotransferase activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol. [EC:2.7.1.142, RHEA:21288]"}
{"concept_id": "C1325150", "aliases": ["ATP/hamamelose 2'-phosphotransferase activity", "hamamelose kinase (phosphorylating)", "ATP:D-hamamelose 2'-phosphotransferase activity", "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)"], "types": ["T044"], "canonical_name": "hamamelose kinase activity", "definition": "Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H(+). [EC:2.7.1.102, RHEA:22796]"}
{"concept_id": "C1325151", "aliases": ["GTP:5-hydroxy-L-lysine O-phosphotransferase activity", "guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity", "hydroxylysine kinase (phosphorylating)"], "types": ["T044"], "canonical_name": "hydroxylysine kinase activity", "definition": "Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H(+). [EC:2.7.1.81, RHEA:19049]"}
{"concept_id": "C1325152", "aliases": ["inositol polyphosphate multikinase activity", "IpmK", "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+). [MetaCyc:2.7.1.151-RXN]", "canonical_name": "inositol-1,4,5-trisphosphate 6-kinase activity"}
{"concept_id": "C1325153", "aliases": ["1D-myo-inositol-tetrakisphosphate 1-kinase activity", "inositol tetrakisphosphate 1-kinase activity", "inositol-tetrakisphosphate 1-kinase activity", "inositol 3,4,5,6-tetrakisphosphate 1-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN]", "canonical_name": "ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity"}
{"concept_id": "C1325154", "aliases": ["ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity", "inositol-tetrakisphosphate 5-kinase activity", "inositol tetrakisphosphate 5-kinase activity", "inositol 1,3,4,6-tetrakisphosphate 5-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN]", "canonical_name": "1D-myo-inositol-tetrakisphosphate 5-kinase activity"}
{"concept_id": "C1325156", "aliases": ["ATP:macrolide 2'-O-phosphotransferase activity"], "types": ["T044"], "canonical_name": "macrolide 2'-kinase activity", "definition": "Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H(+) + oleandomycin 2'-O-phosphate. [EC:2.7.1.136, RHEA:18333]"}
{"concept_id": "C1325157", "aliases": ["nucleotide:nucleoside 5'-phosphotransferase activity", "nucleotide:2'-nucleoside 5'-phosphotransferase activity", "nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity", "nonspecific nucleoside phosphotransferase activity"], "types": ["T044"], "canonical_name": "nucleoside phosphotransferase activity", "definition": "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate. [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN]"}
{"concept_id": "C1325158", "aliases": ["pantetheine kinase (phosphorylating)", "ATP:pantetheine 4'-phosphotransferase activity"], "types": ["T044"], "canonical_name": "pantetheine kinase activity", "definition": "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate. [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN]"}
{"concept_id": "C1325159", "aliases": ["phosphoenolpyruvate:glycerone phosphotransferase activity"], "types": ["T044"], "canonical_name": "phosphoenolpyruvate-glycerone phosphotransferase activity", "definition": "Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate. [EC:2.7.1.121, RHEA:18381]"}
{"concept_id": "C1325160", "aliases": ["glucose-phosphate kinase activity", "phosphoglucokinase (phosphorylating)", "ATP:D-glucose-1-phosphate 6-phosphotransferase activity", "ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity"], "types": ["T044"], "canonical_name": "phosphoglucokinase activity", "definition": "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H(+). [EC:2.7.1.10, RHEA:13377]"}
{"concept_id": "C1325161", "aliases": ["phosphoramidate:hexose 1-phosphotransferase activity", "phosphoramidic-hexose transphosphorylase activity", "phosphoramidate-hexose transphosphorylase activity"], "types": ["T044"], "canonical_name": "phosphoramidate-hexose phosphotransferase activity", "definition": "Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3. [EC:2.7.1.62, MetaCyc:2.7.1.62-RXN]"}
{"concept_id": "C1325162", "aliases": ["ATP:D-ribose-5-phosphate 1-phosphotransferase activity", "phosphoribokinase (phosphorylating)"], "types": ["T044"], "canonical_name": "phosphoribokinase activity", "definition": "Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H(+). [EC:2.7.1.18, RHEA:21216]"}
{"concept_id": "C1325163", "aliases": ["polyphosphate-D-(+)-glucose-6-phosphotransferase activity", "polyphosphate:D-glucose 6-phosphotransferase activity", "polyphosphate-glucose 6-phosphotransferase activity", "polyphosphate glucokinase activity"], "types": ["T044"], "canonical_name": "polyphosphate-glucose phosphotransferase activity", "definition": "Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate. [EC:2.7.1.63, MetaCyc:2.7.1.63-RXN]"}
{"concept_id": "C1325164", "aliases": [], "types": ["T044"], "canonical_name": "protamine kinase activity"}
{"concept_id": "C1325165", "aliases": ["ATP:pseudouridine 5'-phosphotransferase activity", "pseudouridine kinase (phosphorylating)"], "types": ["T044"], "canonical_name": "pseudouridine kinase activity", "definition": "Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H(+) + pseudouridine 5'-phosphate. [EC:2.7.1.83, RHEA:22448]"}
{"concept_id": "C1325166", "aliases": ["opsin kinase activity", "opsin kinase (phosphorylating) activity", "STK14", "rhodopsin kinase activity", "GRK7", "ATP:rhodopsin phosphotransferase activity", "rhodopsin kinase (phosphorylating) activity", "GRK1"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin. [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]", "canonical_name": "RK"}
{"concept_id": "C1325167", "aliases": ["G-1-P phosphotransferase activity", "alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity", "riboflavine phosphotransferase activity", "D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity"], "types": ["T044"], "canonical_name": "riboflavin phosphotransferase activity", "definition": "Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN. [EC:2.7.1.42, RHEA:20409]"}
{"concept_id": "C1325168", "aliases": ["nicotinamide riboside kinase activity", "ribosylnicotinamide kinase (phosphorylating)", "ATP:N-ribosylnicotinamide 5'-phosphotransferase activity"], "types": ["T044"], "canonical_name": "ribosylnicotinamide kinase activity", "definition": "Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide. [EC:2.7.1.22, PMID:17914902, RHEA:14017]"}
{"concept_id": "C1325169", "aliases": ["ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity", "scyllo-inosamine kinase (phosphorylating)", "scyllo-inosamine kinase activity", "ATP:inosamine phosphotransferase activity"], "types": ["T044"], "canonical_name": "scyllo-inosamine 4-kinase activity", "definition": "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H(+). [EC:2.7.1.65, RHEA:18605]"}
{"concept_id": "C1325170", "aliases": ["ATP:sedoheptulose 7-phosphotransferase activity", "sedoheptulokinase (phosphorylating)", "heptulokinase activity"], "types": ["T044"], "canonical_name": "sedoheptulokinase activity", "definition": "Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate. [EC:2.7.1.14, RHEA:23844]"}
{"concept_id": "C1325171", "aliases": ["streptomycin 3''-phosphotransferase activity", "ATP:streptomycin 3''-phosphotransferase activity", "streptomycin 3''-kinase (phosphorylating)"], "types": ["T044"], "canonical_name": "streptomycin 3''-kinase activity", "definition": "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 3''-phosphate. [EC:2.7.1.87, RHEA:18377]"}
{"concept_id": "C1325172", "aliases": ["SM 6-kinase activity"], "types": ["T044"], "canonical_name": "streptomycin 6-kinase activity"}
{"concept_id": "C1325173", "aliases": ["ATP:D-tagatose 6-phosphotransferase activity", "D-tagatose 6-phosphate kinase activity", "tagatose 6-phosphate kinase (phosphorylating)"], "types": ["T044"], "canonical_name": "tagatose kinase activity", "definition": "Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H(+). [EC:2.7.1.101, RHEA:15513]"}
{"concept_id": "C1325174", "aliases": ["[Tau protein] kinase activity", "glycogen synthase kinase-3beta activity", "tau kinase activity", "GSK", "STK31", "tau-protein kinase activity", "TPK I", "TTK", "protein tau kinase activity", "TPK", "tau protein kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]", "canonical_name": "TPK II"}
{"concept_id": "C1325175", "aliases": ["ATP:D-glyceraldehyde 3-phosphotransferase activity", "triose kinase activity", "trio triose kinase (phosphorylating)", "D-triokinase activity"], "types": ["T044"], "canonical_name": "triokinase activity", "definition": "Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+). [EC:2.7.1.28, RHEA:13941]"}
{"concept_id": "C1325176", "aliases": ["tropomyosin kinase (phosphorylating) activity", "ATP:tropomyosin O-phosphotransferase activity", "STK"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin. [EC:2.7.11.28, MetaCyc:TROPOMYOSIN-KINASE-RXN]", "canonical_name": "tropomyosin kinase activity"}
{"concept_id": "C1325177", "aliases": ["viomycin phosphotransferase activity", "capreomycin phosphotransferase activity", "ATP:viomycin O-phosphotransferase activity"], "types": ["T044"], "canonical_name": "viomycin kinase activity", "definition": "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin. [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN]"}
{"concept_id": "C1325178", "aliases": ["xylitol phosphotransferase activity", "ATP:xylitol 5-phosphotransferase activity"], "types": ["T044"], "canonical_name": "xylitol kinase activity", "definition": "Catalysis of the reaction: ATP + xylitol = ADP + 2 H(+) + xylitol 5-phosphate. [EC:2.7.1.122, RHEA:20209]"}
{"concept_id": "C1325179", "aliases": ["BCKD kinase activity", "ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity", "branched-chain 2-oxo acid dehydrogenase kinase activity", "BCK", "STK2", "BCODH kinase activity", "branched-chain keto acid dehydrogenase kinase activity", "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity", "branched-chain alpha-ketoacid dehydrogenase kinase activity", "3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity", "branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate. [EC:2.7.11.4]", "canonical_name": "[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity"}
{"concept_id": "C1325180", "aliases": ["ACK2", "acetyl-CoA carboxylase kinase activity", "ATP:acetyl-CoA carboxylase phosphotransferase activity", "acetyl coenzyme A carboxylase kinase (phosphorylating) activity", "acetyl-CoA carboxylase kinase (AMP-activated) activity", "[acetyl-CoA carboxylase] kinase activity", "ACK3", "acetyl-CoA carboxylase kinase (cAMP-independent) activity", "STK5", "acetyl-coenzyme A carboxylase kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate. [EC:2.7.11.27, MetaCyc:[ACETYL-COA-CARBOXYLASE]-KINASE-RXN]", "canonical_name": "AMPK"}
{"concept_id": "C1325181", "aliases": ["ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity", "hydroxymethylglutaryl coenzyme A reductase kinase activity", "STK29", "[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity", "AMPK", "HMG-CoA reductase kinase activity", "beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity", "3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity", "hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity", "hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity", "hydroxymethylglutaryl-CoA reductase kinase activity", "3-hydroxy-3-methylglutaryl-CoA reductase kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP. [EC:2.7.11.31, MetaCyc:2.7.1.109-RXN]", "canonical_name": "hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity"}
{"concept_id": "C1325182", "aliases": ["pheochromocytoma tyrosine hydroxylase-associated kinase activity", "[tyrosine 3-monooxygenase] kinase activity", "tyrosine 3-monooxygenase kinase activity", "STK4", "ATP:tyrosine-3-monoxygenase phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]. [EC:2.7.11.6, MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN]", "canonical_name": "tyrosine 3-monooxygenase kinase (phosphorylating) activity"}
{"concept_id": "C1325183", "aliases": ["acetate kinase (pyrophosphate) activity", "diphosphate:acetate phosphotransferase activity", "pyrophosphate-acetate phosphotransferase activity"], "types": ["T044"], "canonical_name": "acetate kinase (diphosphate) activity", "definition": "Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate. [EC:2.7.2.12, RHEA:24276]"}
{"concept_id": "C1325184", "aliases": ["branched-chain fatty acid kinase activity"], "types": ["T044"], "canonical_name": "branched-chain-fatty-acid kinase activity"}
{"concept_id": "C1325185", "aliases": ["ATP:butanoate 1-phosphotransferase activity"], "types": ["T044"], "canonical_name": "butyrate kinase activity", "definition": "Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H(+). [EC:2.7.2.7, RHEA:13585]"}
{"concept_id": "C1325186", "aliases": ["ATP:formate phosphotransferase activity"], "types": ["T044"], "canonical_name": "formate kinase activity", "definition": "Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H(+). [EC:2.7.2.6, RHEA:16009]"}
{"concept_id": "C1325188", "aliases": ["GTP:3-phospho-D-glycerate 1-phosphotransferase activity"], "types": ["T044"], "canonical_name": "phosphoglycerate kinase (GTP) activity", "definition": "Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H(+). [EC:2.7.2.10, RHEA:23332]"}
{"concept_id": "C1325189", "aliases": ["CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity", "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity"], "types": ["T044"], "canonical_name": "1-alkenyl-2-acylglycerol choline phosphotransferase activity", "definition": "Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP. [EC:2.7.8.22, MetaCyc:2.7.8.22-RXN]"}
{"concept_id": "C1325190", "aliases": ["CGPTase activity", "teichoic acid glycerol transferase activity", "glycerophosphate synthetase activity", "poly(glycerol phosphate) polymerase activity", "CDPglycerol glycerophosphotransferase activity", "CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity", "cytidine diphosphoglycerol glycerophosphotransferase activity"], "types": ["T044"], "canonical_name": "CDP-glycerol glycerophosphotransferase activity", "definition": "Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP. [EC:2.7.8.12, MetaCyc:2.7.8.12-RXN]"}
{"concept_id": "C1325191", "aliases": ["CDPribitol ribitolphosphotransferase activity", "polyribitol phosphate polymerase activity", "CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity", "teichoate synthase activity", "poly(ribitol phosphate) synthetase activity", "polyribitol phosphate synthetase activity", "teichoate synthetase activity"], "types": ["T044"], "canonical_name": "CDP-ribitol ribitolphosphotransferase activity", "definition": "Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP. [EC:2.7.8.14, MetaCyc:2.7.8.14-RXN]"}
{"concept_id": "C1325192", "aliases": ["CDP-choline:N-acylsphingosine cholinephosphotransferase activity", "phosphorylcholine-ceramide transferase activity"], "types": ["T044"], "canonical_name": "ceramide cholinephosphotransferase activity", "definition": "Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin. [EC:2.7.8.3, RHEA:16273]"}
{"concept_id": "C1325193", "aliases": ["membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity"], "types": ["T044"], "canonical_name": "membrane-oligosaccharide glycerophosphotransferase activity", "definition": "Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another. [EC:2.7.8.21]"}
{"concept_id": "C1325194", "aliases": ["CDPdiglyceride-choline O-phosphatidyltransferase activity", "PC synthase activity", "CDP-diglyceride-choline O-phosphatidyltransferase activity", "CDP-diacylglycerol:choline O-phosphatidyltransferase activity"], "types": ["T044"], "canonical_name": "phosphatidylcholine synthase activity", "definition": "Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+). [EC:2.7.8.24, RHEA:14597]"}
{"concept_id": "C1325195", "aliases": ["GDP-mannose:phosphomannan mannose phosphotransferase activity"], "types": ["T044"], "canonical_name": "phosphomannan mannosephosphotransferase activity", "definition": "Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP. [EC:2.7.8.9, MetaCyc:2.7.8.9-RXN]"}
{"concept_id": "C1325196", "aliases": ["serine ethanolaminephosphotransferase activity", "serine ethanolamine phosphate synthetase activity", "serinephosphoethanolamine synthase activity", "CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity", "serine ethanolamine phosphodiester synthase activity", "serine-phosphinico-ethanolamine synthase activity"], "types": ["T044"], "canonical_name": "serine-phosphoethanolamine synthase activity", "definition": "Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H(+). [EC:2.7.8.4, RHEA:22656]"}
{"concept_id": "C1325197", "aliases": ["sphingosine choline phosphotransferase activity", "cytidine diphosphocholine-sphingosine cholinephosphotransferase activity", "CDP-choline-sphingosine cholinephosphotransferase activity", "CDP-choline:sphingosine cholinephosphotransferase activity", "phosphorylcholine-sphingosine transferase activity"], "types": ["T044"], "canonical_name": "sphingosine cholinephosphotransferase activity", "definition": "Catalysis of the reaction: CDP-choline + sphingosine = CMP + H(+) + sphingosyl-phosphocholine. [EC:2.7.8.10, RHEA:21224]"}
{"concept_id": "C1325198", "aliases": ["CitG activity", "ATP:dephospho-CoA 5-triphosphoribosyl transferase activity", "ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity", "2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity"], "types": ["T044"], "canonical_name": "triphosphoribosyl-dephospho-CoA synthase activity", "definition": "Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. [EC:2.4.2.52]"}
{"concept_id": "C1325199", "aliases": ["galactose-1-phosphotransferase activity", "UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity", "UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity", "uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity", "galactosyl phosphotransferase activity", "UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity"], "types": ["T044"], "canonical_name": "UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H(+) + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP. [EC:2.7.8.18, RHEA:22440]"}
{"concept_id": "C1325200", "aliases": ["UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity", "GlcPTase activity", "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity", "UDPglucose-glycoprotein glucose phosphotransferase activity", "Glc-phosphotransferase activity", "UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity", "UDP-glucose:glycoprotein glucose-1-phosphotransferase activity"], "types": ["T044"], "canonical_name": "UDP-glucose-glycoprotein glucose phosphotransferase activity", "definition": "Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP. [EC:2.7.8.19, MetaCyc:2.7.8.19-RXN]"}
{"concept_id": "C1325201", "aliases": ["poly(isoprenyl)phosphate galactosephosphatetransferase activity", "poly(isoprenol)-phosphate galactosephosphotransferase activity", "UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity", "undecaprenyl phosphate galactosyl-1-phosphate transferase activity", "poly(isoprenol)-phosphate galactose phosphotransferase activity"], "types": ["T044"], "canonical_name": "undecaprenyl-phosphate galactose phosphotransferase activity", "definition": "Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP. [EC:2.7.8.6, RHEA:11652]"}
{"concept_id": "C1325202", "aliases": ["ATP:agmatine 4-N-phosphotransferase activity", "ATP:agmatine N4-phosphotransferase activity"], "types": ["T044"], "canonical_name": "agmatine kinase activity", "definition": "Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H(+). [EC:2.7.3.10, RHEA:15953]"}
{"concept_id": "C1325203", "aliases": ["phosphoramidate-adenosine diphosphate phosphotransferase activity", "ATP:ammonia phosphotransferase activity", "phosphoramidate-ADP-phosphotransferase activity"], "types": ["T044"], "canonical_name": "ammonia kinase activity", "definition": "Catalysis of the reaction: ATP + NH(4)(+) = ADP + 3 H(+) + phosphoramidate. [EC:2.7.3.8, RHEA:11024]"}
{"concept_id": "C1325204", "aliases": ["ATP:guanidinoacetate N-phosphotransferase activity", "glycocyamine kinase activity", "guanidoacetate kinase activity"], "types": ["T044"], "canonical_name": "guanidinoacetate kinase activity", "definition": "Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H(+) + phosphoguanidinoacetate. [EC:2.7.3.1, RHEA:14145]"}
{"concept_id": "C1325205", "aliases": ["ATP:hypotaurocyamine N-phosphotransferase activity"], "types": ["T044"], "canonical_name": "hypotaurocyamine kinase activity", "definition": "Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H(+). [EC:2.7.3.6, RHEA:24008]"}
{"concept_id": "C1325206", "aliases": ["ATP:lombricine N-phosphotransferase activity"], "types": ["T044"], "canonical_name": "lombricine kinase activity", "definition": "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine. [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN]"}
{"concept_id": "C1325207", "aliases": ["ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity"], "types": ["T044"], "canonical_name": "opheline kinase activity", "definition": "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H(+). [EC:2.7.3.7, RHEA:17553]"}
{"concept_id": "C1325208", "aliases": ["phosphopyruvate--protein phosphotransferase activity", "phosphoenolpyruvate-protein phosphotransferase activity", "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity", "enzyme I of the phosphotransferase system", "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity", "phosphoenolpyruvate sugar phosphotransferase enzyme I activity", "phosphoenolpyruvate--protein phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine. [EC:2.7.3.9]", "canonical_name": "phosphopyruvate--protein factor phosphotransferase activity"}
{"concept_id": "C1325209", "aliases": ["ATP:taurocyamine N-phosphotransferase activity", "ATP:taurocyamine phosphotransferase activity", "taurocyamine phosphotransferase activity"], "types": ["T044"], "canonical_name": "taurocyamine kinase activity", "definition": "Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H(+). [EC:2.7.3.4, RHEA:22516]"}
{"concept_id": "C1325210", "aliases": ["a-glucan, water dikinase activity", "starch-related R1 protein activity", "alpha-glucan,water dikinase activity", "ATP:alpha-glucan, water phosphotransferase activity", "GWD"], "types": ["T044"], "canonical_name": "alpha-glucan, water dikinase activity", "definition": "Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate. [EC:2.7.9.4, MetaCyc:2.7.9.4-RXN]"}
{"concept_id": "C1325212", "aliases": ["ATP:(d)AMP phosphotransferase activity"], "types": ["T044"], "canonical_name": "(deoxy)adenylate kinase activity", "definition": "Catalysis of the reaction: ATP + dAMP = ADP + dADP. [EC:2.7.4.11, MetaCyc:DEOXYADENYLATE-KINASE-RXN]"}
{"concept_id": "C1325213", "aliases": ["deoxynucleoside-5'-monophosphate kinase activity", "deoxynucleoside monophosphate kinase activity", "ATP:deoxynucleoside-phosphate phosphotransferase activity", "deoxyribonucleoside monophosphokinase activity"], "types": ["T044"], "canonical_name": "(deoxy)nucleoside-phosphate kinase activity", "definition": "Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate. [EC:2.7.4.13, MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN]"}
{"concept_id": "C1325214", "aliases": ["3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity", "diphosphoglycerate-polyphosphate phosphotransferase activity", "1,3-diphosphoglycerate-polyphosphate phosphotransferase activity"], "types": ["T044"], "canonical_name": "3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity", "definition": "Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate. [EC:2.7.4.17, MetaCyc:2.7.4.17-RXN]"}
{"concept_id": "C1325215", "aliases": ["ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity"], "types": ["T044"], "canonical_name": "5-methyldeoxycytidine-5'-phosphate kinase activity", "definition": "Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H(+). [EC:2.7.4.19, RHEA:11396]"}
{"concept_id": "C1325216", "aliases": ["dolichylpyrophosphate:polyphosphate phosphotransferase activity", "dolichyl-diphosphate:polyphosphate phosphotransferase activity"], "types": ["T044"], "canonical_name": "dolichyl-diphosphate-polyphosphate phosphotransferase activity", "definition": "Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate. [EC:2.7.4.20, MetaCyc:2.7.4.20-RXN]"}
{"concept_id": "C1325217", "aliases": ["ATP:farnesyl-diphosphate phosphotransferase activity", "farnesyl pyrophosphate kinase activity", "farnesyl-diphosphate kinase activity"], "types": ["T044"], "canonical_name": "farnesyl diphosphate kinase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP. [RHEA:21544]"}
{"concept_id": "C1325218", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown. [GOC:elh, GOC:vw, PMID:16429326]", "canonical_name": "inositol hexakisphosphate kinase activity"}
{"concept_id": "C1325219", "aliases": ["nucleoside-phosphate kinase activity", "ATP:nucleoside-phosphate phosphotransferase activity", "NMP-kinase activity"], "types": ["T044"], "canonical_name": "nucleoside monophosphate kinase activity", "definition": "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1325220", "aliases": ["ATP:(d)NMP phosphotransferase activity"], "types": ["T044"], "canonical_name": "T2-induced deoxynucleotide kinase activity", "definition": "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP. [EC:2.7.4.12, MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN]"}
{"concept_id": "C1325222", "aliases": ["beta-ketoadipate:succinyl-CoA transferase activity", "3-oxoadipate succinyl-CoA transferase activity", "succinyl-CoA:3-oxoadipate CoA-transferase activity", "3-oxoadipate coenzyme A-transferase activity"], "types": ["T044"], "canonical_name": "3-oxoadipate CoA-transferase activity", "definition": "Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA. [EC:2.8.3.6, MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN]"}
{"concept_id": "C1325223", "aliases": ["5-hydroxyvalerate CoA-transferase activity", "acetyl-CoA:5-hydroxypentanoate CoA-transferase activity", "5-hydroxyvalerate coenzyme A transferase activity"], "types": ["T044"], "canonical_name": "5-hydroxypentanoate CoA-transferase activity", "definition": "Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate. [EC:2.8.3.14, RHEA:23496]"}
{"concept_id": "C1325224", "aliases": ["butyryl coenzyme A-acetoacetate coenzyme A-transferase activity", "butyryl-CoA-acetoacetate CoA-transferase activity", "butanoyl-CoA:acetoacetate CoA-transferase activity"], "types": ["T044"], "canonical_name": "butyrate-acetoacetate CoA-transferase activity", "definition": "Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate. [EC:2.8.3.9, RHEA:12961]"}
{"concept_id": "C1325225", "aliases": ["acetyl-CoA:citramalate CoA-transferase activity"], "types": ["T044"], "canonical_name": "citramalate CoA-transferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA. [EC:2.8.3.11, MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN]"}
{"concept_id": "C1325226", "aliases": ["acetyl-CoA:malonate CoA-transferase activity", "malonate coenzyme A-transferase activity"], "types": ["T044"], "canonical_name": "malonate CoA-transferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA. [EC:2.8.3.3, RHEA:18817]"}
{"concept_id": "C1325227", "aliases": ["oxalate coenzyme A-transferase activity", "succinyl-CoA:oxalate CoA-transferase activity", "oxalate CoA-transferase activity", "succinyl-beta-ketoacyl-CoA transferase activity"], "types": ["T044"], "canonical_name": "succinyl-CoA:oxalate CoA-transferase", "definition": "Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate. [EC:2.8.3.2, RHEA:23588]"}
{"concept_id": "C1325228", "aliases": ["citramalate coenzyme A-transferase activity", "itaconate CoA-transferase activity", "succinyl coenzyme A-citramalyl coenzyme A transferase activity", "succinyl-CoA:citramalate CoA-transferase activity"], "types": ["T044"], "canonical_name": "succinate-citramalate CoA-transferase activity", "definition": "Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate. [PMID:16547052, RHEA:38287]"}
{"concept_id": "C1325229", "aliases": ["hydroxymethylglutarate coenzyme A-transferase activity", "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity", "dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity"], "types": ["T044"], "canonical_name": "succinate-hydroxymethylglutarate CoA-transferase activity", "definition": "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate. [EC:2.8.3.13, MetaCyc:2.8.3.13-RXN]"}
{"concept_id": "C1325230", "aliases": ["amine N-sulfotransferase activity", "amine sulphotransferase activity", "arylamine sulfotransferase activity", "3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity"], "types": ["T044"], "canonical_name": "amine sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate. [EC:2.8.2.3, MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN]"}
{"concept_id": "C1325231", "aliases": ["arylsulphate sulphotransferase activity", "ASST", "arylsulfate-phenol sulfotransferase activity", "arylsulfate:phenol sulfotransferase activity"], "types": ["T044"], "canonical_name": "arylsulfate sulfotransferase activity", "definition": "Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate. [EC:2.8.2.22, MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN]"}
{"concept_id": "C1325232", "aliases": ["3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity", "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity", "bile-salt sulphotransferase activity", "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity"], "types": ["T044"], "canonical_name": "bile-salt sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate. [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN]"}
{"concept_id": "C1325233", "aliases": ["choline sulphokinase activity", "choline sulphotransferase activity", "3'-phosphoadenylyl-sulfate:choline sulfotransferase activity"], "types": ["T044"], "canonical_name": "choline sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H(+). [EC:2.8.2.6, RHEA:21984]"}
{"concept_id": "C1325234", "aliases": ["3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity", "chondroitin 4-sulphotransferase activity"], "types": ["T044"], "canonical_name": "chondroitin 4-sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate. [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN]"}
{"concept_id": "C1325235", "aliases": ["3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity", "cortisol sulphotransferase activity", "glucocorticoid sulfotransferase activity"], "types": ["T044"], "canonical_name": "cortisol sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H(+). [EC:2.8.2.18, RHEA:11884]"}
{"concept_id": "C1325236", "aliases": ["3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity", "desulphoglucosinolate sulphotransferase activity", "PAPS-desulfoglucosinolate sulfotransferase activity", "3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity"], "types": ["T044"], "canonical_name": "desulfoglucosinolate sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H(+). [EC:2.8.2.24, RHEA:20281]"}
{"concept_id": "C1325238", "aliases": ["Gal-3-O-sulfotransferase activity", "galactose 3-O-sulphotransferase activity"], "types": ["T044"], "canonical_name": "galactose 3-O-sulfotransferase activity", "definition": "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc. [GOC:ai, PMID:11323440, PMID:11356829]"}
{"concept_id": "C1325239", "aliases": ["3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity", "galactocerebroside sulfotransferase activity", "glycosphingolipid sulfotransferase activity", "GSase", "cerebroside sulfotransferase activity", "galactosylceramide sulphotransferase activity", "galactolipid sulfotransferase activity", "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity", "glycolipid sulfotransferase activity"], "types": ["T044"], "canonical_name": "galactosylceramide sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate. [EC:2.8.2.11, PMID:10727929, RHEA:20613]"}
{"concept_id": "C1325240", "aliases": ["N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity", "GalNAc4S-6ST"], "types": ["T044"], "definition": "Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. [EC:2.8.2.33]", "canonical_name": "3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity"}
{"concept_id": "C1325241", "aliases": ["3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity", "psychosine sulphotransferase activity", "3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity", "PAPS:psychosine sulphotransferase activity"], "types": ["T044"], "canonical_name": "psychosine sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate. [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN]"}
{"concept_id": "C1325242", "aliases": ["7-sulfotransferase activity", "flavonol 7-sulfotransferase activity", "quercetin-3,3'-bissulphate 7-sulphotransferase activity", "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity", "PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity"], "types": ["T044"], "canonical_name": "quercetin-3,3'-bissulfate 7-sulfotransferase activity", "definition": "Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate. [EC:2.8.2.28, MetaCyc:2.8.2.28-RXN]"}
{"concept_id": "C1325243", "aliases": ["quercetin-3-sulphate 3'-sulphotransferase activity", "flavonol 3-sulfotransferase activity", "3'-sulfotransferase activity", "flavonol 3-sulphotransferase activity", "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity", "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity", "flavonol 3'-sulfotransferase activity", "PAPS:flavonol 3-sulfate 3'-sulfotransferase activity"], "types": ["T044"], "canonical_name": "quercetin-3-sulfate 3'-sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,3'-disulfate. [EC:2.8.2.26, RHEA:22504]"}
{"concept_id": "C1325244", "aliases": ["flavonol 4'-sulfotransferase activity", "PAPS:flavonol 3-sulfate 4'-sulfotransferase activity", "quercetin-3-sulphate 4'-sulphotransferase activity", "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity"], "types": ["T044"], "canonical_name": "quercetin-3-sulfate 4'-sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,4'-disulfate. [EC:2.8.2.27, RHEA:17205]"}
{"concept_id": "C1325245", "aliases": ["3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity", "Renilla-luciferin sulphotransferase activity", "luciferin sulfokinase activity", "luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)"], "types": ["T044"], "canonical_name": "Renilla-luciferin sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H(+) + luciferyl sulfate. [EC:2.8.2.10, RHEA:20481]"}
{"concept_id": "C1325246", "aliases": ["3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity", "steroid sulphotransferase activity"], "types": ["T044"], "canonical_name": "steroid sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN]"}
{"concept_id": "C1325247", "aliases": ["triglucosylalkylacylglycerol sulphotransferase activity", "triglucosylmonoalkylmonoacyl sulfotransferase activity", "3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity"], "types": ["T044"], "canonical_name": "triglucosylalkylacylglycerol sulfotransferase activity", "definition": "Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate. [EC:2.8.2.19, MetaCyc:2.8.2.19-RXN]"}
{"concept_id": "C1325248", "aliases": ["3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity", "uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity", "UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity", "uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity"], "types": ["T044"], "canonical_name": "UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H(+) + UDP-N-acetyl-D-galactosamine 4,6-disulfate. [EC:2.8.2.7, RHEA:14337]"}
{"concept_id": "C1325249", "aliases": ["thiosulfate reductase activity", "thiosulfate:dithioerythritol sulfurtransferase activity", "thiosulfate-dithiol sulfurtransferase activity", "thiosulphate-dithiol sulphurtransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite. [EC:2.8.1.5, MetaCyc:2.8.1.5-RXN]", "canonical_name": "TSR"}
{"concept_id": "C1325250", "aliases": ["thiosulphate-thiol sulphurtransferase activity", "thiosulfate:thiol sulfurtransferase activity", "sulfane reductase activity", "glutathione-dependent thiosulfate reductase activity", "sulfane sulfurtransferase activity"], "types": ["T044"], "canonical_name": "thiosulfate-thiol sulfurtransferase activity", "definition": "Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide. [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN]"}
{"concept_id": "C1325251", "aliases": ["transferase activity, transferring alkylthio groups"], "types": ["T044"], "canonical_name": "alkylthioltransferase activity", "definition": "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor). [GOC:ai]"}
{"concept_id": "C1325252", "aliases": ["methyl-coenzyme-M reductase activity", "2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity", "methyl-CoM reductase activity", "coenzyme-B sulphoethylthiotransferase activity", "methyl coenzyme M reductase activity"], "types": ["T044"], "canonical_name": "coenzyme-B sulfoethylthiotransferase activity", "definition": "Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB. [EC:2.8.4.1, RHEA:12532]"}
{"concept_id": "C1325253", "aliases": [], "types": ["T044"], "canonical_name": "caspase regulator activity"}
{"concept_id": "C1325254", "aliases": [], "types": ["T044"], "canonical_name": "caspase inhibitor activity"}
{"concept_id": "C1325255", "aliases": ["Rac GAP activity"], "types": ["T044"], "canonical_name": "Rac GTPase activator activity"}
{"concept_id": "C1325256", "aliases": [], "types": ["T044"], "canonical_name": "L-ornithine carboxy-lyase activator activity"}
{"concept_id": "C1325257", "aliases": ["rubisco activase activity", "ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity", "ribulose-bisphosphate carboxylase activase activity", "rubisco activator"], "types": ["T044"], "definition": "Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate. [PMID:10430961, PMID:10965036, PMID:2404515]", "canonical_name": "ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity"}
{"concept_id": "C1325258", "aliases": [], "types": ["T044"], "canonical_name": "pectinesterase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of pectinesterase. [GOC:ai, PMID:10880981]"}
{"concept_id": "C1325259", "aliases": [], "types": ["T044"], "canonical_name": "GTPase regulator activity", "definition": "Binds to and modulates the activity of a GTPase. [GOC:mah]"}
{"concept_id": "C1325261", "aliases": ["histone acetylase regulator activity"], "types": ["T044"], "canonical_name": "histone acetyltransferase regulator activity", "definition": "Binds to and modulates the activity of histone acetyltransferase. [GOC:bf]"}
{"concept_id": "C1325262", "aliases": [], "types": ["T044"], "canonical_name": "histone deacetylase regulator activity", "definition": "Binds to and modulates the activity of histone deacetylase. [GOC:bf]"}
{"concept_id": "C1325263", "aliases": ["PI3K regulator activity", "phosphoinositide 3-kinase regulator activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase regulator activity", "definition": "Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. [GOC:bf, PMID:9255069]"}
{"concept_id": "C1325264", "aliases": ["1-phosphatidylinositol 3-kinase regulator activity"], "types": ["T044"], "canonical_name": "1-phosphatidylinositol-3-kinase regulator activity", "definition": "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity. [GOC:ai]"}
{"concept_id": "C1325265", "aliases": ["MAT regulator activity"], "types": ["T044"], "canonical_name": "methionine adenosyltransferase regulator activity", "definition": "Binds to and modulates the activity of methionine adenosyltransferase. [GOC:jid, PMID:10644686]"}
{"concept_id": "C1325266", "aliases": [], "types": ["T044"], "canonical_name": "ornithine decarboxylase regulator activity", "definition": "Binds to and modulates the activity of the enzyme ornithine decarboxylase. [GOC:jl]"}
{"concept_id": "C1325270", "aliases": [], "types": ["T044"], "canonical_name": "1-phosphatidylinositol-4-phosphate kinase, class IA", "definition": "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events. [PMID:11050418]"}
{"concept_id": "C1325271", "aliases": [], "types": ["T044"], "canonical_name": "1-phosphatidylinositol-4-phosphate kinase, class IB", "definition": "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins. [PMID:11050418]"}
{"concept_id": "C1325272", "aliases": [], "types": ["T044"], "canonical_name": "1-phosphatidylinositol-5-phosphate kinase", "definition": "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide. [GOC:curators]"}
{"concept_id": "C1325273", "aliases": [], "types": ["T044"], "canonical_name": "aa3-type cytochrome c oxidase", "definition": "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. [EC:1.9.3.1]"}
{"concept_id": "C1325275", "aliases": ["adhesive extracellular matrix constituent"], "types": ["T026"], "canonical_name": "adhesive extracellular matrix constituent", "definition": "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1325281", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "apolipoprotein"}
{"concept_id": "C1325283", "aliases": [], "types": ["T044"], "canonical_name": "ba3-type cytochrome c oxidase", "definition": "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. [EC:1.9.3.1]"}
{"concept_id": "C1325286", "aliases": [], "types": ["T044"], "canonical_name": "caa3-type cytochrome c oxidase", "definition": "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. [EC:1.9.3.1]"}
{"concept_id": "C1325287", "aliases": [], "types": ["T044"], "canonical_name": "cbb3-type cytochrome c oxidase", "definition": "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. [EC:1.9.3.1]"}
{"concept_id": "C1325288", "aliases": [], "types": ["T043"], "canonical_name": "cell cycle regulator", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:krc]"}
{"concept_id": "C1325303", "aliases": ["cyclophilin"], "types": ["T044"], "definition": "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity. [EC:5.2.1.8, ISBN:0198506732]", "canonical_name": "cyclophilin activity"}
{"concept_id": "C1325304", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom. [PMID:1655423]", "canonical_name": "cytochrome"}
{"concept_id": "C1325306", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis. [ISBN:0198547684]", "canonical_name": "cytochrome b/b6"}
{"concept_id": "C1325308", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c. [PMID:1655423]", "canonical_name": "cytochrome c1"}
{"concept_id": "C1325315", "aliases": ["DNA repair enzyme activity"], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:elh]", "canonical_name": "DNA repair enzyme"}
{"concept_id": "C1325316", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:elh]", "canonical_name": "DNA repair protein"}
{"concept_id": "C1325319", "aliases": [], "types": ["T044"], "canonical_name": "DNA replication inhibitor", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325320", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "DNA unwinding factor"}
{"concept_id": "C1325323", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "enterobactin synthetase"}
{"concept_id": "C1325325", "aliases": [], "types": ["T044"], "canonical_name": "extracellular matrix glycoprotein", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]"}
{"concept_id": "C1325326", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome. [ISBN:0198506732]", "canonical_name": "fibrillin"}
{"concept_id": "C1325329", "aliases": [], "types": ["T044"], "canonical_name": "glycopeptide hormone", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1325332", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "GPI-linked ephrin"}
{"concept_id": "C1325336", "aliases": ["heterotrimeric G-protein GTPase, alpha-subunit"], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase, alpha-subunit", "definition": "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1325337", "aliases": ["heterotrimeric G-protein GTPase, beta-subunit"], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase, beta-subunit", "definition": "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1325338", "aliases": ["heterotrimeric G-protein GTPase, gamma-subunit"], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase, gamma-subunit", "definition": "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit. [GOC:mah, ISBN:0198547684]"}
{"concept_id": "C1325342", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin. [ISBN:0198506732]", "canonical_name": "immunophilin"}
{"concept_id": "C1325348", "aliases": [], "types": ["T044"], "canonical_name": "intracellular copper ion transporter", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1325351", "aliases": [], "types": ["T044"], "canonical_name": "lipopeptide hormone", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1325355", "aliases": [], "types": ["T044"], "canonical_name": "lysosomal cysteine-type endopeptidase", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1325361", "aliases": [], "types": ["T044"], "canonical_name": "Mn, Fe superoxide dismutase", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1325364", "aliases": ["binding to mRNA cap", "mRNA cap binding"], "types": ["T045"], "canonical_name": "mRNA cap binding", "definition": "Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule. [GOC:dos]"}
{"concept_id": "C1325366", "aliases": [], "types": ["T044"], "canonical_name": "neuroligin", "definition": "OBSOLETE. A class of ligands for neurexins. [GOC:ai]"}
{"concept_id": "C1325368", "aliases": ["para-aminobenzoic acid synthase", "p-aminobenzoate synthetase", "para-aminobenzoic acid synthase activity"], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:krc]", "canonical_name": "para-aminobenzoic acid (PABA) synthase"}
{"concept_id": "C1325369", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin. [ISBN:0198506732]", "canonical_name": "parvulin"}
{"concept_id": "C1325371", "aliases": [], "types": ["T044"], "canonical_name": "peptide antigen stabilization activity", "definition": "OBSOLETE. Strengthening of a bond with a peptide antigen; a fragment of a foreign protein derived by proteolysis within the cell. [GOC:jid]"}
{"concept_id": "C1325372", "aliases": [], "types": ["T044"], "canonical_name": "peptide stabilization activity", "definition": "OBSOLETE. Strengthening of a bond between peptides. Peptides are compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:jid]"}
{"concept_id": "C1325378", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "polyubiquitin"}
{"concept_id": "C1325387", "aliases": [], "types": ["T044"], "canonical_name": "RNA-directed DNA polymerase, group II intron encoded", "definition": "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo. [EC:2.7.7.49]"}
{"concept_id": "C1325388", "aliases": [], "types": ["T044"], "canonical_name": "RNA-directed DNA polymerase, transposon encoded", "definition": "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo. [EC:2.7.7.49]"}
{"concept_id": "C1325391", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins. [ISBN:0124325653]", "canonical_name": "selectin"}
{"concept_id": "C1325398", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "carrier"}
{"concept_id": "C1325399", "aliases": [], "types": ["T045"], "canonical_name": "snRNA cap binding", "definition": "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule. [GOC:mah]"}
{"concept_id": "C1325401", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "storage protein"}
{"concept_id": "C1325408", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane ephrin", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1325410", "aliases": [], "types": ["T043"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "tumor suppressor"}
{"concept_id": "C1325411", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin"}
{"concept_id": "C1325415", "aliases": [], "types": ["T044"], "canonical_name": "vacuolar carboxypeptidase Y", "definition": "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity. [EC:3.4.16.5]"}
{"concept_id": "C1325417", "aliases": ["vesicle transport", "vesicular transport"], "types": ["T043"], "canonical_name": "vesicle-mediated transport", "definition": "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. [GOC:ai, GOC:mah, ISBN:08789310662000]"}
{"concept_id": "C1325418", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "yolk protein"}
{"concept_id": "C1325419", "aliases": ["RAGE activity", "AGE receptor activity"], "types": ["T044"], "canonical_name": "advanced glycation end-product receptor activity", "definition": "Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins). [GOC:signaling, PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812, Wikipedia:RAGE_(receptor)]"}
{"concept_id": "C1325420", "aliases": ["PGJ receptor activity", "PGJ(2) receptor activity"], "types": ["T044"], "canonical_name": "prostaglandin J receptor activity", "definition": "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. [PMID:12878180]"}
{"concept_id": "C1325422", "aliases": [], "types": ["T044"], "canonical_name": "extracellular matrix structural constituent", "definition": "The action of a molecule that contributes to the structural integrity of the extracellular matrix. [GOC:mah]"}
{"concept_id": "C1325423", "aliases": [], "types": ["T044"], "canonical_name": "extracellular matrix constituent conferring elasticity", "definition": "A component of the extracellular matrix that enables the matrix to recoil after transient stretching. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1325424", "aliases": [], "types": ["T044"], "canonical_name": "extracellular matrix structural constituent conferring compression resistance", "definition": "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1325425", "aliases": [], "types": ["T044"], "canonical_name": "extracellular matrix structural constituent conferring tensile strength", "definition": "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1325426", "aliases": [], "types": ["T044"], "canonical_name": "amide transmembrane transporter activity", "definition": "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1325427", "aliases": [], "types": ["T044"], "canonical_name": "L-aspartate transporter activity"}
{"concept_id": "C1325428", "aliases": [], "types": ["T044"], "canonical_name": "L-glutamate transporter activity"}
{"concept_id": "C1325429", "aliases": [], "types": ["T044"], "canonical_name": "L-serine permease activity"}
{"concept_id": "C1325430", "aliases": [], "types": ["T044"], "canonical_name": "L-threonine permease activity"}
{"concept_id": "C1325431", "aliases": ["L-tryptophan permease activity"], "types": ["T044"], "canonical_name": "L-tryptophan transmembrane transporter activity", "definition": "Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1325432", "aliases": ["L-tyrosine permease activity"], "types": ["T044"], "canonical_name": "L-tyrosine transmembrane transporter activity", "definition": "Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1325433", "aliases": [], "types": ["T044"], "canonical_name": "L-proline permease activity"}
{"concept_id": "C1325434", "aliases": [], "types": ["T044"], "canonical_name": "L-phenylalanine transporter activity"}
{"concept_id": "C1325435", "aliases": [], "types": ["T044"], "canonical_name": "L-tryptophan transporter activity"}
{"concept_id": "C1325436", "aliases": [], "types": ["T044"], "canonical_name": "L-tyrosine transporter activity"}
{"concept_id": "C1325437", "aliases": [], "types": ["T044"], "canonical_name": "L-glutamine transmembrane transporter activity", "definition": "Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1325438", "aliases": [], "types": ["T044"], "canonical_name": "L-histidine transporter activity"}
{"concept_id": "C1325439", "aliases": [], "types": ["T044"], "canonical_name": "L-lysine transmembrane transporter activity", "definition": "Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1325440", "aliases": [], "types": ["T044"], "canonical_name": "D-amino acid transporter activity"}
{"concept_id": "C1325441", "aliases": [], "types": ["T044"], "canonical_name": "D-alanine transporter activity"}
{"concept_id": "C1325442", "aliases": [], "types": ["T044"], "canonical_name": "D-serine transporter activity"}
{"concept_id": "C1325443", "aliases": [], "types": ["T044"], "canonical_name": "L-alanine transporter activity"}
{"concept_id": "C1325444", "aliases": [], "types": ["T044"], "canonical_name": "L-cystine transporter activity"}
{"concept_id": "C1325445", "aliases": [], "types": ["T044"], "canonical_name": "L-diaminopimelate transporter activity"}
{"concept_id": "C1325446", "aliases": ["4-aminobutanoate transporter activity", "GABA transporter activity", "gamma-aminobutyric acid transmembrane transporter activity"], "types": ["T044"], "definition": "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]", "canonical_name": "4-aminobutyrate transporter activity"}
{"concept_id": "C1325447", "aliases": [], "types": ["T044"], "canonical_name": "L-isoleucine transporter activity"}
{"concept_id": "C1325448", "aliases": [], "types": ["T044"], "canonical_name": "L-leucine transporter activity"}
{"concept_id": "C1325449", "aliases": [], "types": ["T044"], "canonical_name": "L-methionine transporter activity"}
{"concept_id": "C1325450", "aliases": [], "types": ["T044"], "canonical_name": "L-ornithine transporter activity"}
{"concept_id": "C1325451", "aliases": [], "types": ["T044"], "canonical_name": "L-proline transporter activity"}
{"concept_id": "C1325452", "aliases": [], "types": ["T044"], "canonical_name": "L-serine transporter activity"}
{"concept_id": "C1325453", "aliases": [], "types": ["T044"], "canonical_name": "L-threonine transporter activity"}
{"concept_id": "C1325454", "aliases": [], "types": ["T044"], "canonical_name": "L-valine transporter activity"}
{"concept_id": "C1325455", "aliases": [], "types": ["T044"], "canonical_name": "beta-alanine transporter activity"}
{"concept_id": "C1325456", "aliases": [], "types": ["T044"], "canonical_name": "homoserine transporter activity"}
{"concept_id": "C1325457", "aliases": [], "types": ["T044"], "canonical_name": "sphingosine transmembrane transporter activity"}
{"concept_id": "C1325458", "aliases": [], "types": ["T044"], "canonical_name": "arbutin transmembrane transporter activity", "definition": "Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, PMID:19965875]"}
{"concept_id": "C1325460", "aliases": [], "types": ["T044"], "canonical_name": "D-galactarate transmembrane transporter activity"}
{"concept_id": "C1325461", "aliases": [], "types": ["T044"], "canonical_name": "D-glucarate transmembrane transporter activity", "definition": "Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1325463", "aliases": [], "types": ["T044"], "canonical_name": "D-galactonate transmembrane transporter activity", "definition": "Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1325464", "aliases": [], "types": ["T044"], "canonical_name": "D-glucuronate transmembrane transporter activity", "definition": "Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1325465", "aliases": [], "types": ["T044"], "canonical_name": "galactose uniporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in). [GOC:ai, TC:2.A.1.1.6]"}
{"concept_id": "C1325466", "aliases": [], "types": ["T044"], "canonical_name": "glucoside transmembrane transporter activity", "definition": "Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1325467", "aliases": [], "types": ["T044"], "canonical_name": "salicin transmembrane transporter activity", "definition": "Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1325468", "aliases": [], "types": ["T044"], "canonical_name": "arabinose transmembrane transporter activity", "definition": "Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1325469", "aliases": [], "types": ["T044"], "canonical_name": "arabinan transmembrane transporter activity", "definition": "Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1325470", "aliases": [], "types": ["T044"], "canonical_name": "L-arabinose transmembrane transporter activity", "definition": "Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1325471", "aliases": ["L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity", "definition": "OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out). [TC:2.A.1.2.15]"}
{"concept_id": "C1325472", "aliases": [], "types": ["T044"], "canonical_name": "D-ribose transmembrane transporter activity", "definition": "Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1325473", "aliases": [], "types": ["T044"], "canonical_name": "D-xylose transmembrane transporter activity", "definition": "Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C1325474", "aliases": ["D-xylose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "D-xylose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in). [TC:2.A.1.1.3]"}
{"concept_id": "C1325475", "aliases": [], "types": ["T044"], "canonical_name": "dextrin transmembrane transporter activity", "definition": "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other. [GOC:jl, GOC:vk]"}
{"concept_id": "C1325476", "aliases": [], "types": ["T044"], "canonical_name": "maltodextrin transmembrane transporter activity", "definition": "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other. [GOC:jl, PMID:15034926]"}
{"concept_id": "C1325477", "aliases": [], "types": ["T044"], "canonical_name": "antimonite porter activity"}
{"concept_id": "C1325478", "aliases": ["acridine:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "acridine:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out). [PMID:10735876]"}
{"concept_id": "C1325479", "aliases": ["concentrative nucleoside transporter activity"], "types": ["T044"], "canonical_name": "nucleoside transmembrane transporter activity, against a concentration gradient", "definition": "Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient. [GOC:tb]"}
{"concept_id": "C1325480", "aliases": ["equilibrative nucleoside transporter activity"], "types": ["T044"], "canonical_name": "nucleoside transmembrane transporter activity, down a concentration gradient", "definition": "Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient. [PMID:10353709, PMID:11749958, PMID:12446811]"}
{"concept_id": "C1325481", "aliases": [], "types": ["T044"], "canonical_name": "depolarization-activated calcium channel"}
{"concept_id": "C1325483", "aliases": [], "types": ["T044"], "canonical_name": "chloramphenicol transporter activity"}
{"concept_id": "C1325484", "aliases": [], "types": ["T044"], "canonical_name": "fosmidomycin transporter activity"}
{"concept_id": "C1325485", "aliases": [], "types": ["T044"], "canonical_name": "polymyxin transporter activity"}
{"concept_id": "C1325487", "aliases": ["HCA transporter activity", "3-phenylpropionate acid transporter activity", "hydrocinnamic acid transporter activity"], "types": ["T044"], "canonical_name": "3-phenylpropionic acid transmembrane transporter activity", "definition": "Enables the transfer of 3-phenylpropionic acid from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C1325488", "aliases": [], "types": ["T044"], "canonical_name": "pyruvate transmembrane transporter activity", "definition": "Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1325490", "aliases": ["high affinity copper ion transmembrane transporter activity", "high affinity copper transporter activity"], "types": ["T044"], "canonical_name": "high-affinity copper ion transmembrane transporter activity", "definition": "Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [TC:9.A.11.1.1]"}
{"concept_id": "C1325491", "aliases": ["low affinity iron ion transmembrane transporter activity", "low affinity iron transporter activity"], "types": ["T044"], "canonical_name": "low-affinity ferric iron ion transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [TC:9.A.9.1.1]"}
{"concept_id": "C1325494", "aliases": ["potassium transporter activity"], "types": ["T044"], "canonical_name": "potassium ion transmembrane transporter activity", "definition": "Enables the transfer of potassium ions (K+) from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1325495", "aliases": ["silver transporter activity"], "types": ["T044"], "canonical_name": "silver ion transmembrane transporter activity", "definition": "Enables the transfer of silver (Ag) ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1325496", "aliases": ["sodium transporter activity"], "types": ["T044"], "canonical_name": "sodium ion transmembrane transporter activity", "definition": "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. [GOC:ai, GOC:BHF]"}
{"concept_id": "C1325499", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum ion transmembrane transporter activity", "definition": "Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1325500", "aliases": [], "types": ["T044"], "canonical_name": "transition metal ion transmembrane transporter activity", "definition": "Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [ISBN:0198506732]"}
{"concept_id": "C1325502", "aliases": [], "types": ["T044"], "canonical_name": "glycolipid transporter activity"}
{"concept_id": "C1325503", "aliases": [], "types": ["T044"], "canonical_name": "xanthine transmembrane transporter activity", "definition": "Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. [GOC:jl]"}
{"concept_id": "C1325504", "aliases": ["adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity", "3'-phosphoadenosine 5'-phosphosulphate transporter activity", "PAPS transporter activity"], "types": ["T044"], "canonical_name": "3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity", "definition": "Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other. [ISBN:0198506732]"}
{"concept_id": "C1325505", "aliases": [], "types": ["T044"], "canonical_name": "carboxylic acid transmembrane transporter activity", "definition": "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). [GOC:ai]"}
{"concept_id": "C1325507", "aliases": [], "types": ["T044"], "canonical_name": "tripeptide transporter activity"}
{"concept_id": "C1325509", "aliases": [], "types": ["T044"], "canonical_name": "group A colicin transmembrane transporter activity", "definition": "Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417]"}
{"concept_id": "C1325513", "aliases": [], "types": ["T044"], "canonical_name": "achromobactin transporter activity"}
{"concept_id": "C1325514", "aliases": [], "types": ["T044"], "canonical_name": "chrysobactin transporter activity"}
{"concept_id": "C1325515", "aliases": ["enterobactin transporter activity", "enterochelin transporter activity"], "types": ["T044"], "canonical_name": "enterobactin transmembrane transporter activity", "definition": "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C1325516", "aliases": [], "types": ["T044"], "canonical_name": "ferrichrome transporter activity"}
{"concept_id": "C1325517", "aliases": [], "types": ["T044"], "canonical_name": "xenobiotic transporter activity"}
{"concept_id": "C1325518", "aliases": ["m-hydroxyphenylpropionic acid transporter activity", "3-(3-hydroxyphenyl)propionic acid transporter activity", "3-hydroxyphenylpropionic acid transporter activity"], "types": ["T044"], "canonical_name": "3-hydroxyphenylpropionic acid transmembrane transporter activity", "definition": "Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C1325519", "aliases": [], "types": ["T044"], "canonical_name": "acridine transporter activity"}
{"concept_id": "C1325520", "aliases": ["alkanesulphonate transporter activity", "alkanesulfonate transporter activity"], "types": ["T044"], "canonical_name": "alkanesulfonate transmembrane transporter activity", "definition": "Enables the directed movement of alkanesulfonate from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C1325521", "aliases": [], "types": ["T044"], "canonical_name": "benzoate transporter activity"}
{"concept_id": "C1325523", "aliases": ["cellular projection"], "types": ["T026"], "canonical_name": "cell projection", "definition": "A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]"}
{"concept_id": "C1325525", "aliases": [], "types": ["T026"], "definition": "The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304]", "canonical_name": "photoreceptor outer segment"}
{"concept_id": "C1325526", "aliases": [], "types": ["T026"], "canonical_name": "photoreceptor outer segment membrane", "definition": "The membrane surrounding the outer segment of a vertebrate photoreceptor. [GOC:jl]"}
{"concept_id": "C1325527", "aliases": ["flagellar basal body, rod", "flagellin-based flagellum basal body, rod"], "types": ["T026"], "canonical_name": "bacterial-type flagellum basal body, rod", "definition": "The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings. [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]"}
{"concept_id": "C1325529", "aliases": [], "types": ["T026"], "canonical_name": "giant axon", "definition": "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses. [GOC:jl, PMID:9705477]"}
{"concept_id": "C1325530", "aliases": [], "types": ["T026"], "canonical_name": "external encapsulating structure", "definition": "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. [GOC:go_curators]"}
{"concept_id": "C1325531", "aliases": [], "types": ["T026"], "definition": "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication. [GOC:mlg]", "canonical_name": "capsule"}
{"concept_id": "C1325534", "aliases": ["outer membrane of cell"], "types": ["T026"], "canonical_name": "cell outer membrane", "definition": "A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. [GOC:md, GOC:mtg_sensu, ISBN:0135712254]"}
{"concept_id": "C1325535", "aliases": ["integral to outer membrane", "integral to cell outer membrane", "integral to external membrane"], "types": ["T026"], "canonical_name": "integral component of cell outer membrane", "definition": "The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1325536", "aliases": ["extensin"], "types": ["T026"], "definition": "An extracellular matrix part that consists of cross-linked glycoproteins. [GOC:mah, PMID:18508691, PMID:7048321]", "canonical_name": "glycoprotein network"}
{"concept_id": "C1325537", "aliases": [], "types": ["T026"], "canonical_name": "hemicellulose network", "definition": "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan. [DOI:10.1016/j.foodchem.2008.11.065, GOC:jid]"}
{"concept_id": "C1325538", "aliases": [], "types": ["T026"], "canonical_name": "pectic matrix", "definition": "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls. [GOC:jid, PMID:11554482]"}
{"concept_id": "C1325539", "aliases": [], "types": ["T026"], "canonical_name": "Casparian strip", "definition": "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants. [GOC:jid]"}
{"concept_id": "C1325540", "aliases": [], "types": ["T026"], "canonical_name": "lignin network", "definition": "An extracellular matrix part that consists of lignin in the form of a three-dimensional polymeric network. Lignins are complex racemic aromatic heteropolymers derived from a variety of phenylpropane monomers coupled together by an assortment of carbon-carbon and ether linkages. Lignin is crucial for structural integrity of the cell wall and stiffness and strength of the stem. In addition, lignin waterproofs the cell wall, enabling transport of water and solutes through the vascular system, and plays a role in protecting plants against pathogens. [GOC:jid, GOC:mah, PMID:14503002, PMID:16662709]"}
{"concept_id": "C1325541", "aliases": [], "types": ["T026"], "canonical_name": "suberin network", "definition": "An extracellular matrix part that consists of fatty acid-derived polymers, including both aromatic and aliphatic components. The suberin network is found in specialized plant cell walls, where it is laid down between the primary wall and plasma membrane, forms protective and wound-healing layers, and provides a water-impermeable diffusion barrier. [GOC:jid, GOC:mah, PMID:18440267, PMID:7706282]"}
{"concept_id": "C1325544", "aliases": [], "types": ["T026"], "canonical_name": "forespore"}
{"concept_id": "C1325546", "aliases": [], "types": ["T026"], "definition": "The portion of the cytoskeleton that lies just beneath the plasma membrane. [GOC:mah]", "canonical_name": "cortical cytoskeleton"}
{"concept_id": "C1325547", "aliases": [], "types": ["T026"], "definition": "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. [GOC:mah]", "canonical_name": "cortical actin cytoskeleton"}
{"concept_id": "C1325548", "aliases": [], "types": ["T026"], "canonical_name": "cortical microtubule, transverse to long axis", "definition": "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition. [ISBN:0943088399]"}
{"concept_id": "C1325549", "aliases": [], "types": ["T026"], "canonical_name": "chlorosome", "definition": "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate. [ISBN:0198506732, PMID:14729689, PMID:15298919]"}
{"concept_id": "C1325550", "aliases": [], "types": ["T026"], "definition": "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]", "canonical_name": "chromatin"}
{"concept_id": "C1325551", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic chromatin"}
{"concept_id": "C1325552", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic nucleosome"}
{"concept_id": "C1325553", "aliases": [], "types": ["T026"], "canonical_name": "nuclear euchromatin"}
{"concept_id": "C1325554", "aliases": [], "types": ["T026"], "canonical_name": "nuclear heterochromatin"}
{"concept_id": "C1325556", "aliases": [], "types": ["T026"], "canonical_name": "XY body", "definition": "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. [GOC:hjd, GOC:mr, PMID:20622855, Wikipedia:XY_sex-determination_system]"}
{"concept_id": "C1325557", "aliases": [], "types": ["T026"], "canonical_name": "nuclear chromatin"}
{"concept_id": "C1325558", "aliases": [], "types": ["T026"], "canonical_name": "nuclear nucleosome"}
{"concept_id": "C1325559", "aliases": [], "types": ["T026"], "canonical_name": "nucleolar chromatin", "definition": "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA. [GOC:mah]"}
{"concept_id": "C1325560", "aliases": ["ribosomal DNA protrusion"], "types": ["T026"], "canonical_name": "rDNA protrusion", "definition": "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining. [PMID:1629244]"}
{"concept_id": "C1325561", "aliases": [], "types": ["T026"], "canonical_name": "chromosome, pericentric region"}
{"concept_id": "C1325562", "aliases": [], "types": ["T026"], "canonical_name": "condensed chromosome, pericentric region"}
{"concept_id": "C1325563", "aliases": ["condensed chromosome kinetochore", "condensed nuclear chromosome kinetochore"], "types": ["T026"], "definition": "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:elh]", "canonical_name": "kinetochore"}
{"concept_id": "C1325565", "aliases": ["Dam1 complex location", "Duo1p-Dam1p-Dad1p complex location", "DDD complex", "condensed nuclear chromosome kinetochore-associated DASH complex location", "condensed nuclear chromosome kinetochore-associated DASH complex", "DASH complex location", "Duo1p-Dam1p-Dad1p complex", "DDD complex location", "Dam1 complex"], "types": ["T026"], "canonical_name": "DASH complex", "definition": "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. [GOC:jl, GOC:vw, PMID:11782438, PMID:11799062, PMID:15632076, PMID:15640796]"}
{"concept_id": "C1325566", "aliases": ["inner kinetochore of condensed chromosome", "inner kinetochore of condensed nuclear chromosome", "inner kinetochore", "condensed nuclear chromosome inner kinetochore"], "types": ["T026"], "definition": "The region of a kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome. [GOC:clt, PMID:10619130, PMID:11483983]", "canonical_name": "condensed chromosome inner kinetochore"}
{"concept_id": "C1325567", "aliases": ["outer kinetochore of condensed chromosome", "outer kinetochore of condensed nuclear chromosome", "condensed nuclear chromosome outer kinetochore", "condensed chromosome outer kinetochore"], "types": ["T026"], "definition": "The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. [GOC:clt, PMID:11483983]", "canonical_name": "outer kinetochore"}
{"concept_id": "C1325568", "aliases": [], "types": ["T026"], "canonical_name": "inner kinetochore plate"}
{"concept_id": "C1325571", "aliases": [], "types": ["T026"], "definition": "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh]", "canonical_name": "chromosome, telomeric region"}
{"concept_id": "C1325573", "aliases": ["nuclear telomere cap complex location"], "types": ["T026"], "canonical_name": "nuclear telomere cap complex", "definition": "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. [GOC:elh]"}
{"concept_id": "C1325575", "aliases": ["telomere cap complex location"], "types": ["T026"], "definition": "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. [GOC:elh]", "canonical_name": "telomere cap complex"}
{"concept_id": "C1325576", "aliases": [], "types": ["T026"], "definition": "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. [GOC:elh]", "canonical_name": "condensed chromosome"}
{"concept_id": "C1325577", "aliases": ["meiotic cohesin complex location"], "types": ["T026"], "canonical_name": "meiotic cohesin complex", "definition": "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex. [GOC:mah, PMID:12750522]"}
{"concept_id": "C1325578", "aliases": ["mitotic cohesin complex location"], "types": ["T026"], "canonical_name": "mitotic cohesin complex", "definition": "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. [GOC:mah, PMID:12750522]"}
{"concept_id": "C1325579", "aliases": ["nuclear cohesin complex location"], "types": ["T026"], "canonical_name": "nuclear cohesin complex", "definition": "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus. [GOC:elh]"}
{"concept_id": "C1325580", "aliases": [], "types": ["T026"], "definition": "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. [GOC:elh]", "canonical_name": "condensed nuclear chromosome"}
{"concept_id": "C1325581", "aliases": ["Rad9-Hus1-Rad1 (9-1-1) clamp complex", "CCC", "checkpoint clamp complex", "Rad9-Hus1-Rad1 (9-1-1) clamp complex location"], "types": ["T026"], "definition": "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. [PMID:12531008]", "canonical_name": "checkpoint clamp complex location"}
{"concept_id": "C1325583", "aliases": [], "types": ["T026"], "canonical_name": "central element", "definition": "A structural unit of the synaptonemal complex found between the lateral elements. [GOC:elh]"}
{"concept_id": "C1325584", "aliases": ["axial element"], "types": ["T026"], "canonical_name": "lateral element", "definition": "A proteinaceous core found between sister chromatids during meiotic prophase. [GOC:elh]"}
{"concept_id": "C1325585", "aliases": [], "types": ["T026"], "canonical_name": "transverse filament", "definition": "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them. [GOC:elh]"}
{"concept_id": "C1325586", "aliases": ["condensin complex location"], "types": ["T026"], "definition": "A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis. [GOC:elh, PMID:17268547, PMID:21795393]", "canonical_name": "condensin complex"}
{"concept_id": "C1325587", "aliases": [], "types": ["T026"], "canonical_name": "prokaryotic ORC"}
{"concept_id": "C1325588", "aliases": ["Go, Ichi, Ni and San complex", "GINS complex", "GINS complex location"], "types": ["T026"], "definition": "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks. [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]", "canonical_name": "Go, Ichi, Ni and San complex location"}
{"concept_id": "C1325589", "aliases": ["nuclear ORC", "eukaryotic ORC", "nuclear origin of replication recognition complex location"], "types": ["T026"], "canonical_name": "nuclear origin of replication recognition complex", "definition": "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus. [GOC:elh]"}
{"concept_id": "C1325591", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast chromosome", "definition": "A circular DNA molecule containing chloroplast encoded genes. [GOC:jl]"}
{"concept_id": "C1325592", "aliases": [], "types": ["T026"], "canonical_name": "replisome", "definition": "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. [GOC:mah, GOC:vw]"}
{"concept_id": "C1325593", "aliases": [], "types": ["T026"], "canonical_name": "W chromosome", "definition": "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females. [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855]"}
{"concept_id": "C1325594", "aliases": [], "types": ["T026"], "canonical_name": "Z chromosome", "definition": "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females. [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855]"}
{"concept_id": "C1325595", "aliases": ["Axin-APC-beta-catenin-GSK3B complex location", "beta-catenin destruction complex", "Axin-APC-beta-catenin-GSK3B complex", "beta-catenin degradation complex", "BDC", "APC-Axin-1-beta-catenin complex", "beta-catenin destruction complex location", "APC-Axin-1-beta-catenin complex location"], "types": ["T026"], "definition": "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. [PMID:14600025]", "canonical_name": "beta-catenin degradation complex location"}
{"concept_id": "C1325596", "aliases": ["P body", "cytoplasmic mRNA processing body"], "types": ["T026"], "definition": "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. [GOC:clt, PMID:12730603]", "canonical_name": "P-body"}
{"concept_id": "C1325597", "aliases": ["von Hippel-Lindau tumor suppressor complex location", "VHL complex", "VHL complex location", "von Hippel-Lindau tumor suppressor complex", "VCB complex location", "pVHL-elongin C-elongin B complex", "pVHL-elongin C-elongin B complex location"], "types": ["T026"], "canonical_name": "VCB complex", "definition": "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1. [GOC:mah, PMID:11865071]"}
{"concept_id": "C1325599", "aliases": [], "types": ["T026"], "canonical_name": "merozoite dense granule membrane", "definition": "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1325600", "aliases": [], "types": ["T026"], "canonical_name": "chromaffin granule membrane", "definition": "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. [GOC:jl]"}
{"concept_id": "C1325601", "aliases": [], "types": ["T026"], "canonical_name": "zymogen granule membrane", "definition": "The lipid bilayer surrounding a zymogen granule. [GOC:jl]"}
{"concept_id": "C1325602", "aliases": ["Vps fifty three tethering complex", "VFT tethering complex", "VFT tethering complex location", "Vps fifty three tethering complex location", "GARP complex location", "Golgi associated retrograde protein complex location", "Golgi associated retrograde protein complex"], "types": ["T026"], "canonical_name": "GARP complex", "definition": "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles. [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]"}
{"concept_id": "C1325603", "aliases": ["primary granule"], "types": ["T026"], "definition": "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:jl, PMID:17152095]", "canonical_name": "azurophil granule"}
{"concept_id": "C1325604", "aliases": ["platelet dense body", "platelet dense granule"], "types": ["T026"], "definition": "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. [GOC:jl, PMID:10403682, PMID:11487378]", "canonical_name": "bull's eye body"}
{"concept_id": "C1325605", "aliases": ["secondary granule"], "types": ["T026"], "canonical_name": "specific granule", "definition": "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:jl, ISBN:0721662544, PMID:7334549]"}
{"concept_id": "C1325607", "aliases": ["actomyosin complex location", "actomyosin complex", "actomyosin"], "types": ["T026"], "definition": "Any complex of actin, myosin, and accessory proteins. [GOC:go_curators]", "canonical_name": "actomyosin structure"}
{"concept_id": "C1325608", "aliases": ["actomyosin, myosin complex location part"], "types": ["T026"], "canonical_name": "actomyosin, myosin complex part", "definition": "The myosin part of any complex of actin, myosin, and accessory proteins. [GOC:go_curators]"}
{"concept_id": "C1325609", "aliases": ["F-actin capping protein complex location"], "types": ["T026"], "canonical_name": "F-actin capping protein complex", "definition": "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. [GOC:go_curators, ISBN:0198599560]"}
{"concept_id": "C1325618", "aliases": ["class IB PI3K complex location", "1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex", "class IB PI3K complex", "1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex location", "phosphoinositide 3-kinase complex, class IB", "phosphatidylinositol 3-kinase complex location, class IB", "phosphoinositide 3-kinase complex location, class IB"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex, class IB", "definition": "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks. [PMID:9255069, PMID:9759495]"}
{"concept_id": "C1325619", "aliases": ["phosphatidylinositol 3-kinase complex location, class III", "class III PI3K complex location", "phosphoinositide 3-kinase complex location, class III", "class III PI3K complex", "phosphoinositide 3-kinase complex, class III"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex, class III", "definition": "A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI). [GOC:bf, PMID:9255069]"}
{"concept_id": "C1325620", "aliases": ["proteasome", "proteasome complex location"], "types": ["T026"], "definition": "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. [GOC:rb, Wikipedia:Proteasome]", "canonical_name": "proteasome complex"}
{"concept_id": "C1325621", "aliases": ["proteasome core complex, alpha-subunit complex location"], "types": ["T026"], "canonical_name": "proteasome core complex, alpha-subunit complex", "definition": "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]"}
{"concept_id": "C1325622", "aliases": ["proteasome core complex, beta-subunit complex location"], "types": ["T026"], "canonical_name": "proteasome core complex, beta-subunit complex", "definition": "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus. [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]"}
{"concept_id": "C1325623", "aliases": ["PA700-dependent proteasome activator"], "types": ["T026"], "definition": "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex. [GOC:mtg_sensu, GOC:rb]", "canonical_name": "proteasome regulatory particle"}
{"concept_id": "C1325624", "aliases": ["proteasome regulatory particle, base subcomplex location"], "types": ["T026"], "canonical_name": "proteasome regulatory particle, base subcomplex", "definition": "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. [GOC:mtg_sensu, GOC:rb]"}
{"concept_id": "C1325625", "aliases": ["proteasome regulatory particle, lid subcomplex location"], "types": ["T026"], "canonical_name": "proteasome regulatory particle, lid subcomplex", "definition": "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. [GOC:rb]"}
{"concept_id": "C1325628", "aliases": ["DNA polymerase complex location"], "types": ["T026"], "canonical_name": "DNA polymerase complex", "definition": "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. [GOC:jl, PMID:12045093]"}
{"concept_id": "C1325629", "aliases": ["RER lumen", "rough ER lumen"], "types": ["T026"], "definition": "The volume enclosed by the membranes of the rough endoplasmic reticulum. [GOC:jid]", "canonical_name": "rough endoplasmic reticulum lumen"}
{"concept_id": "C1325630", "aliases": ["SER lumen", "smooth endoplasmic reticulum lumen"], "types": ["T026"], "definition": "The volume enclosed by the membranes of the smooth endoplasmic reticulum. [GOC:jid]", "canonical_name": "smooth ER lumen"}
{"concept_id": "C1325631", "aliases": ["extrinsic to ER membrane", "extrinsic to endoplasmic reticulum membrane"], "types": ["T026"], "canonical_name": "extrinsic component of endoplasmic reticulum membrane", "definition": "The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:curators, GOC:dos]"}
{"concept_id": "C1325632", "aliases": ["GPIT complex location", "GPI-anchor transamidase complex location", "GPIT complex"], "types": ["T026"], "canonical_name": "GPI-anchor transamidase complex", "definition": "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor. [GOC:jl, GOC:rb, PMID:12802054]"}
{"concept_id": "C1325633", "aliases": ["rough ER membrane", "rough endoplasmic reticulum membrane"], "types": ["T026"], "definition": "The lipid bilayer surrounding the rough endoplasmic reticulum. [GOC:mah]", "canonical_name": "RER membrane"}
{"concept_id": "C1325635", "aliases": ["peptide-loading complex", "peptide-loading complex location", "MHC class I peptide loading complex location", "PLC"], "types": ["T026"], "definition": "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. [GOC:jl, PMID:10631934]", "canonical_name": "MHC class I peptide loading complex"}
{"concept_id": "C1325636", "aliases": ["transporter associated with antigen presentation", "TAP complex location"], "types": ["T026"], "canonical_name": "TAP complex", "definition": "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum. [GOC:jl, PMID:10618487, PMID:10631934]"}
{"concept_id": "C1325637", "aliases": ["external leaflet of endosome membrane", "external side of endosome membrane"], "types": ["T026"], "canonical_name": "cytoplasmic side of endosome membrane", "definition": "The side (leaflet) of the endosome membrane that faces the cytoplasm. [GOC:lr]"}
{"concept_id": "C1325638", "aliases": ["endoplasmic reticulum body"], "types": ["T026"], "canonical_name": "ER body", "definition": "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species. [PMID:11577182]"}
{"concept_id": "C1325639", "aliases": ["glycine cleavage system", "glycine synthase complex", "glycine decarboxylase complex location", "glycine cleavage complex", "glycine cleavage complex location", "glycine dehydrogenase complex location (decarboxylating)", "glycine decarboxylase complex", "glycine dehydrogenase complex (decarboxylating)", "glycine dehydrogenase (decarboxylating) complex location", "glycine synthase complex location"], "types": ["T026"], "definition": "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. [GOC:mah, MetaCyc:GCVMULTI-CPLX]", "canonical_name": "glycine dehydrogenase (decarboxylating) complex"}
{"concept_id": "C1325640", "aliases": ["glycine reductase complex location"], "types": ["T026"], "canonical_name": "glycine reductase complex", "definition": "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C. [GOC:mah, PMID:2018775]"}
{"concept_id": "C1325641", "aliases": ["glycogen particle"], "types": ["T026"], "canonical_name": "glycogen granule", "definition": "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface. [GOC:jl, PMID:12179957]"}
{"concept_id": "C1325642", "aliases": [], "types": ["T026"], "canonical_name": "glycosome membrane", "definition": "The lipid bilayer surrounding a glycosome. [GOC:ai]"}
{"concept_id": "C1325643", "aliases": ["hydrogenosome membrane"], "types": ["T026"], "canonical_name": "hydrogenosomal membrane", "definition": "The lipid bilayer surrounding a hydrogenosome. [GOC:ai]"}
{"concept_id": "C1325644", "aliases": ["glyoxysome membrane"], "types": ["T026"], "canonical_name": "glyoxysomal membrane", "definition": "The lipid bilayer surrounding a glyoxysome. [GOC:ai]"}
{"concept_id": "C1325645", "aliases": [], "types": ["T026"], "canonical_name": "mannosome", "definition": "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction. [GOC:jl, PMID:11912051, PMID:9799531]"}
{"concept_id": "C1325646", "aliases": ["equatorial microtubule organising centre", "EMTOC"], "types": ["T026"], "canonical_name": "equatorial microtubule organizing center", "definition": "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis. [PMID:11792817]"}
{"concept_id": "C1325647", "aliases": ["gamma-tubulin complex location"], "types": ["T026"], "canonical_name": "gamma-tubulin complex", "definition": "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. [GOC:clt, PMID:12134075]"}
{"concept_id": "C1325648", "aliases": ["gamma-tubulin large complex location"], "types": ["T026"], "canonical_name": "gamma-tubulin large complex", "definition": "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe. [GOC:mtg_sensu, PMID:12134075, PMID:17021256]"}
{"concept_id": "C1325649", "aliases": ["mitochondrial intermembrane space protein transporter complex location"], "types": ["T026"], "canonical_name": "mitochondrial intermembrane space protein transporter complex", "definition": "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. [PMID:12581629]"}
{"concept_id": "C1325650", "aliases": ["gamma DNA polymerase complex location"], "types": ["T026"], "canonical_name": "gamma DNA polymerase complex", "definition": "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA. [GOC:jl, PMID:12045093]"}
{"concept_id": "C1325651", "aliases": [], "types": ["T026"], "definition": "The region of a mitochondrion to which the DNA is confined. [GOC:jl]", "canonical_name": "mitochondrial nucleoid"}
{"concept_id": "C1325652", "aliases": ["mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex location"], "types": ["T026"], "canonical_name": "mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex", "definition": "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus. [GOC:mtg_sensu, PMID:9395502]"}
{"concept_id": "C1325653", "aliases": ["respirasome", "respiratory chain", "mitochondrial respiratory supercomplex", "mitochondrial respiratory chain supercomplex", "membrane electron transport chain", "mitochondrial electron transport chain", "mitochondrial respirasome"], "types": ["T026"], "definition": "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. [GOC:curators, GOC:ecd, ISBN:0198547684]", "canonical_name": "mitochondrial respiratory chain"}
{"concept_id": "C1325654", "aliases": ["mitochondrial respiratory chain complex I, membrane segment location"], "types": ["T026"], "canonical_name": "mitochondrial respiratory chain complex I, membrane segment", "definition": "The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. [GOC:jid, GOC:mtg_sensu, ISBN:0716749556]"}
{"concept_id": "C1325655", "aliases": ["mitochondrial respiratory chain complex I, peripheral segment location"], "types": ["T026"], "canonical_name": "mitochondrial respiratory chain complex I, peripheral segment", "definition": "The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. [GOC:jid, GOC:mtg_sensu, ISBN:0716749556]"}
{"concept_id": "C1325656", "aliases": ["pre-sequence translocase-associated import motor", "mitochondrial import motor", "PAM complex location, Tim23 associated import motor", "PAM complex location", "presequence translocase-associated import motor", "PAM complex"], "types": ["T026"], "canonical_name": "PAM complex, Tim23 associated import motor", "definition": "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix. [GOC:mcc, GOC:vw, PMID:14517234, PMID:14638855]"}
{"concept_id": "C1325657", "aliases": ["Tim22 complex", "mitochondrial inner membrane protein insertion complex", "TIM22 mitochondrial import inner membrane insertion complex location", "Tim22 complex location", "mitochondrial inner membrane protein insertion complex location"], "types": ["T026"], "canonical_name": "TIM22 mitochondrial import inner membrane insertion complex", "definition": "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12. [PMID:12191765, PMID:27554484]"}
{"concept_id": "C1325658", "aliases": ["mitochondrial proton-transporting ATP synthase, peripheral stalk", "mitochondrial proton-transporting ATP synthase location, stator stalk"], "types": ["T026"], "canonical_name": "mitochondrial proton-transporting ATP synthase, stator stalk", "definition": "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. [GOC:mtg_sensu, PMID:10838056]"}
{"concept_id": "C1325659", "aliases": ["TOB complex", "mitochondrial sorting and assembly machinery complex location", "mitochondrial sorting and assembly machinery complex", "SAM complex location", "TOB complex location"], "types": ["T026"], "definition": "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex. [PMID:12891361]", "canonical_name": "SAM complex"}
{"concept_id": "C1325660", "aliases": ["mitochondrial RNase P complex location", "mitochondrial ribonuclease P complex location", "mitochondrial RNase P complex"], "types": ["T026"], "canonical_name": "mitochondrial ribonuclease P complex", "definition": "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans. [GOC:mah, PMID:12045094, PMID:27187488]"}
{"concept_id": "C1325661", "aliases": [], "types": ["T026"], "definition": "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378]", "canonical_name": "costamere"}
{"concept_id": "C1325662", "aliases": ["myrosinase complex location", "thioglucosidase complex location", "myrosinase complex"], "types": ["T026"], "canonical_name": "thioglucosidase complex", "definition": "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds. [PMID:10682349]"}
{"concept_id": "C1325663", "aliases": ["Toc complex location"], "types": ["T026"], "canonical_name": "Toc complex", "definition": "Protein translocon complex at the chloroplast outer membrane. [PMID:10646606]"}
{"concept_id": "C1325664", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast nucleoid", "definition": "The region of a chloroplast to which the DNA is confined. [GOC:jl]"}
{"concept_id": "C1325665", "aliases": ["magnesium chelatase complex location"], "types": ["T026"], "canonical_name": "magnesium chelatase complex", "definition": "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner. [PMID:11842180]"}
{"concept_id": "C1325666", "aliases": [], "types": ["T026"], "canonical_name": "chromoplast membrane", "definition": "Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope. [GOC:ai, GOC:mah]"}
{"concept_id": "C1325667", "aliases": ["cyanelle RNase P complex", "cyanelle RNase P complex location", "cyanelle ribonuclease P complex location"], "types": ["T026"], "canonical_name": "cyanelle ribonuclease P complex", "definition": "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. [GOC:mah, PMID:12045094]"}
{"concept_id": "C1325668", "aliases": [], "types": ["T026"], "canonical_name": "prothylakoid", "definition": "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light. [GOC:jl, PMID:11532175]"}
{"concept_id": "C1325669", "aliases": [], "types": ["T026"], "canonical_name": "prothylakoid membrane", "definition": "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. [GOC:jl, PMID:11532175]"}
{"concept_id": "C1325670", "aliases": [], "types": ["T026"], "canonical_name": "plastid nucleoid", "definition": "The region of a plastid to which the DNA is confined. [GOC:jl]"}
{"concept_id": "C1325671", "aliases": [], "types": ["T026"], "canonical_name": "proplastid nucleoid", "definition": "The region of a proplastid to which the DNA is confined. [GOC:jl]"}
{"concept_id": "C1325672", "aliases": ["plastid-encoded plastid RNA polymerase complex A location", "PEP-A"], "types": ["T026"], "canonical_name": "plastid-encoded plastid RNA polymerase complex A", "definition": "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex. [PMID:10946105]"}
{"concept_id": "C1325673", "aliases": ["PEP-B", "plastid-encoded plastid RNA polymerase complex B location"], "types": ["T026"], "canonical_name": "plastid-encoded plastid RNA polymerase complex B", "definition": "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation. [PMID:10946105]"}
{"concept_id": "C1325674", "aliases": ["starch grain"], "types": ["T026"], "definition": "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. [GOC:jl, PMID:11217978]", "canonical_name": "starch granule"}
{"concept_id": "C1325675", "aliases": [], "types": ["T026"], "definition": "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. [PMID:10567516]", "canonical_name": "preribosome"}
{"concept_id": "C1325676", "aliases": [], "types": ["T026"], "definition": "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis. [PMID:10567516]", "canonical_name": "nucleolar preribosome"}
{"concept_id": "C1325677", "aliases": [], "types": ["T026"], "definition": "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]", "canonical_name": "90S preribosome"}
{"concept_id": "C1325678", "aliases": ["Noc1p-Noc2p complex location"], "types": ["T026"], "canonical_name": "Noc1p-Noc2p complex", "definition": "A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis. [PMID:12446671]"}
{"concept_id": "C1325679", "aliases": ["Noc4p-Nop14p complex location", "Nop7 subcomplex", "Nop7 complex", "Nop7 complex location", "Nop7 subcomplex location"], "types": ["T026"], "canonical_name": "Noc4p-Nop14p complex", "definition": "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis. [PMID:12446671]"}
{"concept_id": "C1325680", "aliases": [], "types": ["T026"], "canonical_name": "66S preribosome"}
{"concept_id": "C1325681", "aliases": ["Noc2p-Noc3p complex location"], "types": ["T026"], "canonical_name": "Noc2p-Noc3p complex", "definition": "A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis. [PMID:12446671]"}
{"concept_id": "C1325682", "aliases": [], "types": ["T026"], "canonical_name": "43S preribosome"}
{"concept_id": "C1325683", "aliases": [], "types": ["T026"], "canonical_name": "protein body", "definition": "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins. [GOC:jl, PMID:7704047]"}
{"concept_id": "C1325684", "aliases": ["cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex location"], "types": ["T026"], "canonical_name": "cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex", "definition": "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. [GOC:mtg_sensu, PMID:9395502]"}
{"concept_id": "C1325689", "aliases": ["succinate-CoA ligase complex location"], "types": ["T026"], "canonical_name": "succinate-CoA ligase complex", "definition": "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP. [GOC:jl, PMID:10671455]"}
{"concept_id": "C1325690", "aliases": [], "types": ["T026"], "canonical_name": "mast cell granule", "definition": "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. [GOC:jl, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215]"}
{"concept_id": "C1325691", "aliases": ["HOPS complex location"], "types": ["T026"], "canonical_name": "HOPS complex", "definition": "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. [PMID:10944212, PMID:23645161]"}
{"concept_id": "C1325692", "aliases": ["central vacuole"], "types": ["T026"], "canonical_name": "central vacuole", "definition": "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination. [ISBN:9780815341116, Wikipedia:Vacuole]"}
{"concept_id": "C1325693", "aliases": [], "types": ["T026"], "canonical_name": "yolk granule", "definition": "Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed. [GOC:jl, PMID:18046696, PMID:6337890]"}
{"concept_id": "C1325694", "aliases": ["extrachromosomal DNA"], "types": ["T026"], "definition": "DNA structures that are not part of a chromosome. [GOC:ai]", "canonical_name": "extrachromosomal DNA location"}
{"concept_id": "C1325695", "aliases": ["MAT complex location", "MAT complex", "methionine adenosyltransferase complex location"], "types": ["T026"], "canonical_name": "methionine adenosyltransferase complex", "definition": "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules. [EC:2.5.1.6, GOC:jid, PMID:10644686]"}
{"concept_id": "C1325696", "aliases": ["apoB mRNA editing enzyme complex location", "APOBEC", "apoB mRNA editing enzyme complex", "apolipoprotein B mRNA editing enzyme complex location"], "types": ["T026"], "canonical_name": "apolipoprotein B mRNA editing enzyme complex", "definition": "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP). [PMID:10781591]"}
{"concept_id": "C1325697", "aliases": [], "types": ["T026"], "canonical_name": "dense nuclear body", "definition": "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously. [PMID:10233976]"}
{"concept_id": "C1325698", "aliases": ["X chromosome located dosage compensation complex location, transcription activating"], "types": ["T026"], "canonical_name": "X chromosome located dosage compensation complex, transcription activating", "definition": "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster. [GOC:ma, GOC:mr, GOC:mtg_sensu, PMID:20622855, Wikipedia:XY_sex-determination_system]"}
{"concept_id": "C1325699", "aliases": ["FACT complex", "Facilitates chromatin transcription complex location", "Facilitates chromatin transcription complex"], "types": ["T026"], "definition": "A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage. [PMID:12934006, PMID:12934007, PMID:16678108, PMID:34731638]", "canonical_name": "FACT complex location"}
{"concept_id": "C1325700", "aliases": ["germ-cell nucleus"], "types": ["T026"], "canonical_name": "germ cell nucleus", "definition": "The nucleus of a germ cell, a reproductive cell in multicellular organisms. [CL:0000586, GOC:go_curators]"}
{"concept_id": "C1325702", "aliases": ["primary oocyte nucleus"], "types": ["T026"], "canonical_name": "germinal vesicle", "definition": "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity. [GOC:jl, GOC:mtg_sensu, PMID:19019837]"}
{"concept_id": "C1325703", "aliases": ["megaspore mother cell nucleus"], "types": ["T026"], "canonical_name": "megasporocyte nucleus", "definition": "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents. [GOC:jl, ISBN:0618254153]"}
{"concept_id": "C1325704", "aliases": [], "types": ["T026"], "canonical_name": "antipodal cell nucleus", "definition": "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents. [CL:0000537, GOC:jl]"}
{"concept_id": "C1325705", "aliases": [], "types": ["T026"], "canonical_name": "megagametophyte egg cell nucleus", "definition": "The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1325706", "aliases": [], "types": ["T026"], "canonical_name": "polar nucleus", "definition": "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus. [ISBN:0618254153]"}
{"concept_id": "C1325708", "aliases": ["microspore mother cell nucleus", "pollen mother cell nucleus"], "types": ["T026"], "canonical_name": "microsporocyte nucleus", "definition": "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte. [GOC:tair_curators, ISBN:047186840X]"}
{"concept_id": "C1325709", "aliases": [], "types": ["T026"], "canonical_name": "generative cell nucleus", "definition": "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells. [GOC:tair_curators]"}
{"concept_id": "C1325710", "aliases": ["Rad50 complex location", "Rad50 complex", "MRX complex", "Rad50-Rad32-Nbs1 complex", "MRN complex location", "Rad50-Rad32-Nbs1 complex location", "Mre11 complex location", "RMX complex location", "RMX complex", "RAD50-MRE11-NBN complex", "RAD50-MRE11-NBN complex location", "MRX complex location", "MRN complex"], "types": ["T026"], "canonical_name": "Mre11 complex", "definition": "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]"}
{"concept_id": "C1325711", "aliases": ["Noc complex location"], "types": ["T026"], "canonical_name": "Noc complex", "definition": "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis. [PMID:12446671]"}
{"concept_id": "C1325712", "aliases": ["nucleolar RNase P complex", "nucleolar RNase P complex location", "nucleolar ribonuclease P complex location"], "types": ["T026"], "canonical_name": "nucleolar ribonuclease P complex", "definition": "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. [GOC:mah, PMID:12045094]"}
{"concept_id": "C1325713", "aliases": ["BRM complex location", "brahma complex location", "BRM complex"], "types": ["T026"], "canonical_name": "brahma complex", "definition": "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof. [GOC:bhm, PMID:10809665, PMID:12482982]"}
{"concept_id": "C1325714", "aliases": ["RENT complex location"], "types": ["T026"], "canonical_name": "RENT complex", "definition": "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit. [PMID:12196389]"}
{"concept_id": "C1325715", "aliases": ["Set1C", "Set1C/COMPASS complex location", "Set1/COMPASS complex location", "COMPASS complex location", "COMPASS complex", "Set1/COMPASS complex"], "types": ["T026"], "canonical_name": "Set1C/COMPASS complex", "definition": "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]"}
{"concept_id": "C1325716", "aliases": ["Lid2 complex location"], "types": ["T026"], "canonical_name": "Lid2 complex", "definition": "A protein complex involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid2, Ash2, Jmj3, Snt2, and Sdc1. [PMID:12488447]"}
{"concept_id": "C1325717", "aliases": ["replication-coupling assembly factor complex", "replication-coupling assembly factor complex location", "RCAF complex location"], "types": ["T026"], "canonical_name": "RCAF complex", "definition": "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4. [GOC:bf, PMID:10591219]"}
{"concept_id": "C1325718", "aliases": ["DNA-directed RNA polymerase II, core complex", "RNA polymerase II, core complex location", "DNA-directed RNA polymerase II, core complex location"], "types": ["T026"], "canonical_name": "RNA polymerase II, core complex", "definition": "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. [GOC:krc, GOC:mtg_sensu]"}
{"concept_id": "C1325719", "aliases": ["transcription factor TFIID complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIID complex", "definition": "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]"}
{"concept_id": "C1325720", "aliases": ["histone methyltransferase complex location"], "types": ["T026"], "canonical_name": "histone methyltransferase complex", "definition": "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. [GOC:bf]"}
{"concept_id": "C1325721", "aliases": ["ESC/E(Z) complex location", "PRC2 complex", "Extra Sex Combs/Enhancer of Zeste complex", "PRC2 complex location", "Extra Sex Combs/Enhancer of Zeste complex location"], "types": ["T026"], "canonical_name": "ESC/E(Z) complex", "definition": "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]"}
{"concept_id": "C1325722", "aliases": [], "types": ["T026"], "definition": "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs). [GOC:bf, PMID:10984439]", "canonical_name": "omega speckle"}
{"concept_id": "C1325723", "aliases": ["Mlu1-box binding factor", "DSC1 transcription factor complex", "MBF transcription complex", "DSC1 transcription factor complex location", "MBF"], "types": ["T026"], "definition": "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p. [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385]", "canonical_name": "MBF transcription complex location"}
{"concept_id": "C1325724", "aliases": ["Polycomb repressive complex location 1", "PRC1 complex location", "Polycomb repressive complex 1"], "types": ["T026"], "definition": "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. [GOC:bf, PMID:10412979]", "canonical_name": "PRC1 complex"}
{"concept_id": "C1325725", "aliases": ["retrotransposon nucleocapsid", "Virus-like particle"], "types": ["T026"], "definition": "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog. [GOC:clt, PMID:10861903]", "canonical_name": "VLP"}
{"concept_id": "C1325726", "aliases": ["transcription export complex location", "TREX complex", "TREX complex location"], "types": ["T026"], "canonical_name": "transcription export complex", "definition": "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. [GOC:krc, PMID:11979277]"}
{"concept_id": "C1325727", "aliases": ["THO complex location"], "types": ["T026"], "canonical_name": "THO complex", "definition": "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits. [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]"}
{"concept_id": "C1325728", "aliases": ["plasma membrane proton-transporting ATP synthase location, stator stalk"], "types": ["T026"], "canonical_name": "plasma membrane proton-transporting ATP synthase, stator stalk", "definition": "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species. [GOC:mtg_sensu, PMID:10838056]"}
{"concept_id": "C1325729", "aliases": ["miRNP complex location", "miRNP complex", "micro-ribonucleoprotein complex location"], "types": ["T026"], "canonical_name": "micro-ribonucleoprotein complex"}
{"concept_id": "C1325730", "aliases": ["RNase P complex", "RNase P complex location", "ribonuclease P complex location"], "types": ["T026"], "canonical_name": "ribonuclease P complex", "definition": "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. [GOC:mah, PMID:12045094]"}
{"concept_id": "C1325733", "aliases": ["RNA polymerase complex location", "multisubunit RNA polymerase"], "types": ["T026"], "canonical_name": "RNA polymerase complex", "definition": "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. [GOC:mah]"}
{"concept_id": "C1325734", "aliases": ["retromer complex location"], "types": ["T026"], "canonical_name": "retromer complex", "definition": "A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157]"}
{"concept_id": "C1325735", "aliases": ["retromer, cargo recognition complex", "cargo-selective retromer subcomplex", "retromer complex location, inner shell", "retromer, cargo recognition complex location", "cargo-selective retromer subcomplex location", "retromer, cargo-selective complex location", "retromer complex, inner shell", "retromer CSC", "retromer, CRC"], "types": ["T026"], "canonical_name": "retromer, cargo-selective complex", "definition": "The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals. [GOC:bf, PMID:11102511, PMID:26220253, PMID:9700157]"}
{"concept_id": "C1325736", "aliases": ["retromer, tubulation complex location", "heterodimeric membrane-deforming retromer subcomplex location", "retromer complex, outer shell", "heterodimeric membrane-deforming retromer subcomplex", "SNX-BAR dimer", "retromer complex location, outer shell"], "types": ["T026"], "canonical_name": "retromer, tubulation complex", "definition": "The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6. [GOC:bf, PMID:26220253, PMID:9700157]"}
{"concept_id": "C1325737", "aliases": ["activin receptor complex location"], "types": ["T026"], "canonical_name": "activin receptor complex", "definition": "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed. [PMID:8307945, PMID:8622651]"}
{"concept_id": "C1325738", "aliases": ["IL-20 receptor complex", "interleukin-20 receptor complex location", "IL-20 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-20 receptor complex", "definition": "A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits. [PMID:12351624]"}
{"concept_id": "C1325739", "aliases": ["NADPH oxidase complex"], "types": ["T026"], "definition": "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. [GOC:jl, PMID:11483596, PMID:12440767]", "canonical_name": "NADPH oxidase complex location"}
{"concept_id": "C1325740", "aliases": ["plasma membrane hydrogen ion-transporting ATPase V0 domain"], "types": ["T026"], "canonical_name": "plasma membrane proton-transporting V-type ATPase, V0 domain", "definition": "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane. [GOC:mah]"}
{"concept_id": "C1325741", "aliases": ["plasma membrane hydrogen ion-transporting ATPase V1 domain"], "types": ["T026"], "canonical_name": "plasma membrane proton-transporting V-type ATPase, V1 domain", "definition": "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane. [GOC:mah]"}
{"concept_id": "C1325742", "aliases": ["pore complex location", "pore"], "types": ["T026"], "definition": "A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. [ISBN:0198506732]", "canonical_name": "pore complex"}
{"concept_id": "C1325744", "aliases": ["subapical complex", "subapical complex location"], "types": ["T026"], "definition": "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells. [PMID:11752566, PMID:12500938]", "canonical_name": "SAC"}
{"concept_id": "C1325745", "aliases": ["MHC protein complex location"], "types": ["T026"], "canonical_name": "MHC protein complex", "definition": "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]"}
{"concept_id": "C1325746", "aliases": ["MHC class I protein complex location"], "types": ["T026"], "canonical_name": "MHC class I protein complex", "definition": "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149]"}
{"concept_id": "C1325747", "aliases": ["MHC class II protein complex location"], "types": ["T026"], "canonical_name": "MHC class II protein complex", "definition": "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]"}
{"concept_id": "C1325748", "aliases": ["presynaptic membrane", "pre-synaptic membrane"], "types": ["T026"], "definition": "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]", "canonical_name": "presynaptic plasma membrane"}
{"concept_id": "C1325749", "aliases": [], "types": ["T026"], "canonical_name": "adventitious septum", "definition": "A cell septum whose formation is independent of nuclear division. [GOC:clt, ISBN:0471940526]"}
{"concept_id": "C1325750", "aliases": ["divison septum", "complete septum"], "types": ["T026"], "canonical_name": "division septum", "definition": "A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments. [GOC:clt, GOC:vw]"}
{"concept_id": "C1325751", "aliases": [], "types": ["T026"], "canonical_name": "porous cell septum", "definition": "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments. [GOC:clt]"}
{"concept_id": "C1325752", "aliases": [], "types": ["T026"], "canonical_name": "dolipore septum", "definition": "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome). [GOC:clt]"}
{"concept_id": "C1325753", "aliases": [], "types": ["T026"], "canonical_name": "primary septum"}
{"concept_id": "C1325754", "aliases": [], "types": ["T026"], "canonical_name": "mating projection base", "definition": "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone. [GOC:mcc]"}
{"concept_id": "C1325756", "aliases": [], "types": ["T026"], "canonical_name": "apoplast", "definition": "The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. [GOC:jid]"}
{"concept_id": "C1325757", "aliases": ["activin complex location"], "types": ["T026"], "canonical_name": "activin complex", "definition": "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit. [GOC:go_curators]"}
{"concept_id": "C1325758", "aliases": ["activin A complex", "activin A complex location"], "types": ["T026"], "definition": "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A). [GOC:go_curators]", "canonical_name": "inhibin beta-A"}
{"concept_id": "C1325759", "aliases": ["activin AB complex"], "types": ["T026"], "definition": "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B. [GOC:go_curators]", "canonical_name": "activin AB complex location"}
{"concept_id": "C1325760", "aliases": ["activin B complex location", "activin B complex"], "types": ["T026"], "definition": "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B). [GOC:go_curators]", "canonical_name": "inhibin beta-B"}
{"concept_id": "C1325761", "aliases": [], "types": ["T026"], "definition": "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. [GOC:jl, GOC:rl, PMID:10580165]", "canonical_name": "chylomicron"}
{"concept_id": "C1325762", "aliases": ["isoamylase complex location"], "types": ["T026"], "definition": "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. [GOC:jl, PMID:10333591]", "canonical_name": "isoamylase complex"}
{"concept_id": "C1325763", "aliases": [], "types": ["T026"], "canonical_name": "germline ring canal", "definition": "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells. [GOC:mtg_sensu, PMID:9635420, PMID:9655801]"}
{"concept_id": "C1325765", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A type of intermediate filament. [ISBN:0716731363, ISBN:0815316194]", "canonical_name": "acidic keratin"}
{"concept_id": "C1325766", "aliases": [], "types": ["T044"], "canonical_name": "axonemal dynein heavy chain", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325767", "aliases": [], "types": ["T044"], "canonical_name": "axonemal dynein intermediate chain", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325768", "aliases": [], "types": ["T044"], "canonical_name": "axonemal dynein intermediate light chain", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325769", "aliases": [], "types": ["T044"], "canonical_name": "axonemal dynein light chain", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325770", "aliases": ["B cell receptor accessory molecule complex location"], "types": ["T026"], "canonical_name": "B cell receptor accessory molecule complex", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325771", "aliases": [], "types": ["T026"], "canonical_name": "basic/neutral keratin", "definition": "OBSOLETE. A type of intermediate filament. [ISBN:0716731363, ISBN:0815316194]"}
{"concept_id": "C1325774", "aliases": ["Gram-negative-bacterium-type cell wall", "cell wall inner membrane"], "types": ["T026"], "definition": "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. [GOC:mlg, ISBN:0815108893]", "canonical_name": "1-2nm peptidoglycan-based cell wall"}
{"concept_id": "C1325776", "aliases": [], "types": ["T044"], "canonical_name": "cytoplasmic dynein heavy chain", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325777", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "cytoplasmic dynein intermediate chain"}
{"concept_id": "C1325778", "aliases": [], "types": ["T044"], "canonical_name": "cytoplasmic dynein intermediate light chain", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325779", "aliases": [], "types": ["T044"], "canonical_name": "cytoplasmic dynein light chain", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325780", "aliases": [], "types": ["T026"], "definition": "The large subunit of a ribosome located in the cytosol. [GOC:mtg_sensu]", "canonical_name": "cytosolic large ribosomal subunit"}
{"concept_id": "C1325782", "aliases": [], "types": ["T026"], "definition": "The small subunit of a ribosome located in the cytosol. [GOC:mtg_sensu]", "canonical_name": "cytosolic small ribosomal subunit"}
{"concept_id": "C1325784", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "debranching enzyme activity"}
{"concept_id": "C1325785", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A type of intermediate filament. [ISBN:0815316194]", "canonical_name": "desmin"}
{"concept_id": "C1325788", "aliases": ["eukaryotic translation initiation factor 4 complex"], "types": ["T026"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "eukaryotic translation initiation factor 4 complex location"}
{"concept_id": "C1325790", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "fibrinogen alpha chain"}
{"concept_id": "C1325791", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "fibrinogen beta chain"}
{"concept_id": "C1325792", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "fibrinogen gamma chain"}
{"concept_id": "C1325793", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes. [ISBN:0716731363]", "canonical_name": "glial fibrillary acidic protein"}
{"concept_id": "C1325794", "aliases": ["Golgi-plasma membrane transport vesicle", "Golgi to plasma membrane constitutive secretory pathway transport vesicle"], "types": ["T026"], "canonical_name": "Golgi to plasma membrane transport vesicle", "definition": "A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. [GOC:kad, GOC:mah]"}
{"concept_id": "C1325795", "aliases": ["Golgi-vacuole transport vesicle"], "types": ["T026"], "canonical_name": "Golgi to vacuole transport vesicle", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1325796", "aliases": ["AP-1 adaptor complex location", "HA1 clathrin adaptor", "AP-1 adaptor complex"], "types": ["T026"], "definition": "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). [GOC:mah, PMID:10611976, PMID:21097499]", "canonical_name": "HA1"}
{"concept_id": "C1325803", "aliases": [], "types": ["T044"], "canonical_name": "intermediate filament associated protein", "definition": "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks. [GOC:ajp, PMID:9484600]"}
{"concept_id": "C1325804", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "laminin receptor protein"}
{"concept_id": "C1325806", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "lysosomal membrane hydrogen-transporting ATPase"}
{"concept_id": "C1325807", "aliases": ["membrane attack complex location protein alphaM chain"], "types": ["T026"], "canonical_name": "membrane attack complex protein alphaM chain", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325808", "aliases": ["membrane attack complex location protein beta2 chain"], "types": ["T026"], "canonical_name": "membrane attack complex protein beta2 chain", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325812", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall. [GOC:mah, PMID:9529891]", "canonical_name": "murein sacculus"}
{"concept_id": "C1325815", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system. [ISBN:0716731363]", "canonical_name": "peripherin"}
{"concept_id": "C1325817", "aliases": ["Ran-binding protein"], "types": ["T044"], "canonical_name": "Ran protein binding", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325821", "aliases": ["SCF complex location substrate recognition subunit"], "types": ["T026"], "canonical_name": "SCF complex substrate recognition subunit", "definition": "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex. [PMID:11790542, PMID:9857172]"}
{"concept_id": "C1325822", "aliases": ["secretory vesicle membrane"], "types": ["T026"], "canonical_name": "secretory vesicle membrane", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1325828", "aliases": [], "types": ["T044"], "canonical_name": "type I intermediate filament associated protein", "definition": "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates. [GOC:ajp, PMID:9484600]"}
{"concept_id": "C1325829", "aliases": [], "types": ["T044"], "canonical_name": "type II intermediate filament associated protein", "definition": "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks. [GOC:ajp, PMID:9484600]"}
{"concept_id": "C1325830", "aliases": [], "types": ["T044"], "canonical_name": "type III intermediate filament associated protein", "definition": "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane. [GOC:ajp, PMID:9484600]"}
{"concept_id": "C1325832", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "vacuolar hydrogen-transporting ATPase"}
{"concept_id": "C1325833", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. A type of intermediate filament. [ISBN:0716731363]", "canonical_name": "vimentin"}
{"concept_id": "C1325834", "aliases": [], "types": ["T026"], "canonical_name": "viral glycoprotein", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1325835", "aliases": ["glucose-1-phosphate adenylyltransferase complex location"], "types": ["T026"], "canonical_name": "glucose-1-phosphate adenylyltransferase complex", "definition": "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits. [GOC:tb, PMID:12748181]"}
{"concept_id": "C1325836", "aliases": ["behavioural response to cocaine"], "types": ["T055"], "canonical_name": "behavioral response to cocaine", "definition": "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. [GOC:jid]"}
{"concept_id": "C1325837", "aliases": ["behavioural response to ethanol"], "types": ["T055"], "canonical_name": "behavioral response to ethanol", "definition": "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus. [GOC:jid]"}
{"concept_id": "C1325838", "aliases": ["behavioural response to ether"], "types": ["T055"], "canonical_name": "behavioral response to ether", "definition": "Any process that results in a change in the behavior of an organism as a result of an ether stimulus. [GOC:jid]"}
{"concept_id": "C1325839", "aliases": ["behavioural response to nicotine"], "types": ["T055"], "canonical_name": "behavioral response to nicotine", "definition": "Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. [GOC:bf, ISBN:0198506732]"}
{"concept_id": "C1325840", "aliases": ["behavioural response to pain"], "types": ["T055"], "canonical_name": "behavioral response to pain", "definition": "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid]"}
{"concept_id": "C1325841", "aliases": ["behavioral response to drought", "behavioral response to thirst", "behavioural response to water deprivation"], "types": ["T055"], "canonical_name": "behavioral response to water deprivation", "definition": "Any process that results in a change in the behavior of an organism as a result of deprivation of water. [GOC:jl]"}
{"concept_id": "C1325842", "aliases": ["behavioural response to starvation"], "types": ["T039"], "canonical_name": "behavioral response to starvation", "definition": "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment. [GOC:go_curators]"}
{"concept_id": "C1325844", "aliases": [], "types": ["T039"], "canonical_name": "pumping behavior"}
{"concept_id": "C1325845", "aliases": [], "types": ["T039"], "canonical_name": "regulation of pharyngeal pumping", "definition": "Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes. [GOC:cab1, PMID:2181052]"}
{"concept_id": "C1325846", "aliases": ["unconditional response"], "types": ["T041"], "canonical_name": "nonassociative learning", "definition": "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment. [ISBN:0582227089]"}
{"concept_id": "C1325847", "aliases": [], "types": ["T040"], "definition": "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched. [ISBN:0582227089]", "canonical_name": "sensitization"}
{"concept_id": "C1325851", "aliases": [], "types": ["T040"], "canonical_name": "backward locomotion", "definition": "Posterior movement of an organism, e.g. following the direction of the tail of an animal. [GOC:go_curators]"}
{"concept_id": "C1325852", "aliases": [], "types": ["T040"], "canonical_name": "regulation of backward locomotion", "definition": "Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism. [GOC:go_curators]"}
{"concept_id": "C1325853", "aliases": [], "types": ["T040"], "canonical_name": "forward locomotion", "definition": "Anterior movement of an organism, following the direction of the head of the animal. [GOC:go_curators]"}
{"concept_id": "C1325854", "aliases": [], "types": ["T040"], "canonical_name": "regulation of forward locomotion", "definition": "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism. [GOC:go_curators]"}
{"concept_id": "C1325858", "aliases": ["regulation of behaviour"], "types": ["T055"], "canonical_name": "regulation of behavior", "definition": "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. [GOC:go_curators, GOC:pr]"}
{"concept_id": "C1325859", "aliases": [], "types": ["T038"], "canonical_name": "regulation of circadian rhythm", "definition": "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C1325860", "aliases": ["downregulation of circadian rhythm", "down-regulation of circadian rhythm", "down regulation of circadian rhythm"], "types": ["T039"], "canonical_name": "negative regulation of circadian rhythm", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. [GOC:go_curators]"}
{"concept_id": "C1325861", "aliases": ["upregulation of circadian rhythm", "up-regulation of circadian rhythm", "up regulation of circadian rhythm"], "types": ["T039"], "canonical_name": "positive regulation of circadian rhythm", "definition": "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. [GOC:go_curators]"}
{"concept_id": "C1325862", "aliases": [], "types": ["T038"], "canonical_name": "regulation of circadian sleep/wake cycle", "definition": "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. [GOC:jl]"}
{"concept_id": "C1325863", "aliases": [], "types": ["T040"], "canonical_name": "regulation of post-mating oviposition"}
{"concept_id": "C1325865", "aliases": ["male courtship behavior, licking", "male courtship behaviour, proboscis-mediated licking", "male courtship behaviour, licking"], "types": ["T054"], "canonical_name": "male courtship behavior, proboscis-mediated licking", "definition": "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11092827]"}
{"concept_id": "C1325866", "aliases": ["male courtship behaviour, orientation prior to leg tapping and wing vibration"], "types": ["T054"], "canonical_name": "male courtship behavior, orientation prior to leg tapping and wing vibration", "definition": "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster. [GOC:sensu, PMID:11092827]"}
{"concept_id": "C1325867", "aliases": ["male courtship behaviour, tapping to detect pheromone", "male courtship behaviour, tapping", "male courtship behavior, tapping"], "types": ["T054"], "canonical_name": "male courtship behavior, tapping to detect pheromone", "definition": "The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11092827]"}
{"concept_id": "C1325868", "aliases": ["male courtship behavior, wing extension", "male courtship behaviour, wing extension", "male courtship behaviour, veined wing extension"], "types": ["T054"], "canonical_name": "male courtship behavior, veined wing extension", "definition": "The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1325869", "aliases": ["male courtship behaviour, wing vibration", "male courtship behaviour, veined wing vibration", "male courtship behavior, wing vibration"], "types": ["T054"], "canonical_name": "male courtship behavior, veined wing vibration", "definition": "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11092827]"}
{"concept_id": "C1325871", "aliases": [], "types": ["T040"], "canonical_name": "sperm ejaculation", "definition": "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]"}
{"concept_id": "C1325872", "aliases": ["mating behaviour, sex discrimination"], "types": ["T040"], "canonical_name": "mating behavior, sex discrimination", "definition": "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner. [GOC:jid, GOC:pr, PMID:12486700]"}
{"concept_id": "C1325873", "aliases": ["copulatory plug biosynthesis", "copulatory plug formation", "copulatory plug deposition", "mating plug deposition"], "types": ["T054"], "canonical_name": "mating plug formation", "definition": "The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males. [GOC:jl, PMID:11267893]"}
{"concept_id": "C1325874", "aliases": [], "types": ["T040"], "canonical_name": "circadian sleep/wake cycle", "definition": "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. [GOC:jl, http://www.sleepquest.com]"}
{"concept_id": "C1325875", "aliases": [], "types": ["T040"], "canonical_name": "circadian sleep/wake cycle, sleep", "definition": "The part of the circadian sleep/wake cycle where the organism is asleep. [GOC:ai]"}
{"concept_id": "C1325876", "aliases": [], "types": ["T040"], "canonical_name": "circadian sleep/wake cycle, non-REM sleep", "definition": "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions. [GOC:jl, http://www.sleepquest.com]"}
{"concept_id": "C1325877", "aliases": [], "types": ["T040"], "canonical_name": "circadian sleep/wake cycle, REM sleep", "definition": "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity. [GOC:jl, ISBN:0395825172]"}
{"concept_id": "C1325878", "aliases": [], "types": ["T040"], "canonical_name": "circadian sleep/wake cycle, wakefulness", "definition": "The part of the circadian sleep/wake cycle where the organism is not asleep. [GOC:jl, PMID:12575468]"}
{"concept_id": "C1325880", "aliases": ["cellular physiological process", "cellular process"], "types": ["T043"], "definition": "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators, GOC:isa_complete]", "canonical_name": "cell physiology"}
{"concept_id": "C1325881", "aliases": [], "types": ["T043"], "canonical_name": "biofilm formation", "definition": "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. [GOC:di, PMID:11932229]"}
{"concept_id": "C1325882", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell recognition", "definition": "Cell recognition between cells. May involve the formation of specialized cell junctions. [ISBN:0824072820]"}
{"concept_id": "C1325883", "aliases": [], "types": ["T043"], "canonical_name": "cell-matrix recognition", "definition": "Cell recognition that involves the interaction of the cell with the extracellular matrix. [ISBN:0824072820]"}
{"concept_id": "C1325884", "aliases": [], "types": ["T043"], "canonical_name": "contact guidance", "definition": "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells. [ISBN:0824072820]"}
{"concept_id": "C1325885", "aliases": [], "types": ["T043"], "canonical_name": "leukocyte activation-dependent arrest", "definition": "The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation. [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]"}
{"concept_id": "C1325886", "aliases": [], "types": ["T043"], "canonical_name": "leukocyte tethering or rolling", "definition": "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). [GOC:bf, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538, Wikipedia:Leukocyte_extravasation]"}
{"concept_id": "C1325887", "aliases": ["focal adhesion formation"], "types": ["T043"], "canonical_name": "focal adhesion assembly", "definition": "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. [GOC:jid, GOC:mah]"}
{"concept_id": "C1325888", "aliases": ["adrenaline secretion"], "types": ["T043"], "canonical_name": "epinephrine secretion", "definition": "The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system. [GOC:ef, GOC:jid]"}
{"concept_id": "C1325889", "aliases": ["follitropin secretion", "follicle stimulating hormone secretion", "FSH secretion"], "types": ["T043"], "canonical_name": "follicle-stimulating hormone secretion", "definition": "The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. [ISBN:0198506732]"}
{"concept_id": "C1325890", "aliases": ["regulation of follicle stimulating hormone secretion", "regulation of FSH secretion"], "types": ["T043"], "canonical_name": "regulation of follicle-stimulating hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone. [GOC:ai]"}
{"concept_id": "C1325891", "aliases": ["downregulation of follicle-stimulating hormone secretion", "down-regulation of follicle-stimulating hormone secretion", "negative regulation of follicle stimulating hormone secretion", "down regulation of follicle-stimulating hormone secretion"], "types": ["T043"], "canonical_name": "negative regulation of follicle-stimulating hormone secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone. [GOC:ai]"}
{"concept_id": "C1325892", "aliases": ["upregulation of follicle-stimulating hormone secretion", "up-regulation of follicle-stimulating hormone secretion", "positive regulation of follicle stimulating hormone secretion", "up regulation of follicle-stimulating hormone secretion"], "types": ["T043"], "canonical_name": "positive regulation of follicle-stimulating hormone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone. [GOC:ai]"}
{"concept_id": "C1325893", "aliases": [], "types": ["T043"], "canonical_name": "histamine secretion", "definition": "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems. [GOC:mah, ISBN:0198506732, ISBN:0781735149]"}
{"concept_id": "C1325894", "aliases": ["noradrenaline secretion"], "types": ["T043"], "canonical_name": "norepinephrine secretion", "definition": "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. [GOC:ef, GOC:jid]"}
{"concept_id": "C1325895", "aliases": [], "types": ["T043"], "canonical_name": "regulation of insulin secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of insulin. [GOC:ai]"}
{"concept_id": "C1325897", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. [GOC:ai]"}
{"concept_id": "C1325898", "aliases": ["down-regulation of hormone secretion", "downregulation of hormone secretion", "down regulation of hormone secretion"], "types": ["T043"], "canonical_name": "negative regulation of hormone secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. [GOC:ai]"}
{"concept_id": "C1325899", "aliases": ["upregulation of hormone secretion", "up-regulation of hormone secretion", "up regulation of hormone secretion"], "types": ["T043"], "canonical_name": "positive regulation of hormone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. [GOC:ai]"}
{"concept_id": "C1325900", "aliases": ["5-hydroxytryptamine secretion", "5-HT secretion"], "types": ["T043"], "canonical_name": "serotonin secretion", "definition": "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. [GOC:ef, ISBN:0198506732, ISBN:0781735149]"}
{"concept_id": "C1325901", "aliases": [], "types": ["T043"], "canonical_name": "catecholamine secretion", "definition": "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:ai, GOC:ef]"}
{"concept_id": "C1325902", "aliases": [], "types": ["T043"], "canonical_name": "regulation of catecholamine secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. [GOC:ai]"}
{"concept_id": "C1325903", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neurotransmitter secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. [GOC:ai]"}
{"concept_id": "C1325904", "aliases": ["downregulation of neurotransmitter secretion", "down regulation of neurotransmitter secretion", "down-regulation of neurotransmitter secretion"], "types": ["T043"], "canonical_name": "negative regulation of neurotransmitter secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. [GOC:ai]"}
{"concept_id": "C1325905", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synapse structure or activity", "definition": "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai]"}
{"concept_id": "C1325906", "aliases": ["regulation of synapse organisation", "regulation of synapse organization and biogenesis", "regulation of synapse structure"], "types": ["T042"], "canonical_name": "regulation of synapse organization", "definition": "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1325907", "aliases": ["regulation of synaptic transmission", "modulation of synaptic transmission", "regulation of chemical synaptic transmission"], "types": ["T042"], "canonical_name": "modulation of chemical synaptic transmission", "definition": "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. [GOC:ai]"}
{"concept_id": "C1325908", "aliases": ["down-regulation of synaptic transmission", "downregulation of synaptic transmission", "down regulation of synaptic transmission"], "types": ["T042"], "canonical_name": "negative regulation of synaptic transmission", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. [GOC:ai]"}
{"concept_id": "C1325909", "aliases": ["up regulation of synaptic transmission", "up-regulation of synaptic transmission", "upregulation of synaptic transmission"], "types": ["T042"], "canonical_name": "positive regulation of synaptic transmission", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. [GOC:ai]"}
{"concept_id": "C1325910", "aliases": ["evasion of host defence response"], "types": ["T040"], "canonical_name": "evasion or tolerance of host defense response"}
{"concept_id": "C1325911", "aliases": [], "types": ["T040"], "canonical_name": "active evasion of host immune response"}
{"concept_id": "C1325914", "aliases": ["active immune evasion via regulation of host cytokine network", "active evasion of host immune response via regulation of host cytokine network", "active immune evasion via modulation of host cytokine network"], "types": ["T040"], "canonical_name": "evasion of host immune response via regulation of host cytokine network", "definition": "Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction. [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation]"}
{"concept_id": "C1325915", "aliases": [], "types": ["T040"], "canonical_name": "passive evasion of host immune response"}
{"concept_id": "C1325917", "aliases": ["induction of an organ"], "types": ["T042"], "canonical_name": "organ induction", "definition": "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. [ISBN:0878932437]"}
{"concept_id": "C1325918", "aliases": [], "types": ["T043"], "canonical_name": "response to extracellular stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. [GOC:go_curators]"}
{"concept_id": "C1325919", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to iron ion starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions. [GOC:mg]"}
{"concept_id": "C1325920", "aliases": ["cellular response to sulphate starvation"], "types": ["T043"], "canonical_name": "cellular response to sulfate starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate. [GOC:sm]"}
{"concept_id": "C1325921", "aliases": ["cellular response to drought"], "types": ["T043"], "canonical_name": "cellular response to water deprivation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water. [GOC:go_curators]"}
{"concept_id": "C1325922", "aliases": ["glutamine sensing", "glutamine perception", "glutamine detection"], "types": ["T043"], "canonical_name": "detection of glutamine", "definition": "The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1325923", "aliases": ["antigen receptor-mediated signalling pathway"], "types": ["T044"], "canonical_name": "antigen receptor-mediated signaling pathway", "definition": "The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. [GOC:add]"}
{"concept_id": "C1325924", "aliases": ["B cell receptor signaling pathway", "B lymphocyte receptor signalling pathway", "B lymphocyte receptor signaling pathway", "B-lymphocyte receptor signaling pathway", "B-cell receptor signalling pathway", "B-cell receptor signaling pathway", "B-lymphocyte receptor signalling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. [GOC:add]", "canonical_name": "B cell receptor signalling pathway"}
{"concept_id": "C1325925", "aliases": ["regulation of B lymphocyte receptor signalling pathway", "regulation of B-cell receptor signaling pathway", "regulation of B lymphocyte receptor signaling pathway", "regulation of B-lymphocyte receptor signalling pathway", "regulation of B-lymphocyte receptor signaling pathway", "regulation of B-cell receptor signalling pathway", "regulation of B cell receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of B cell receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. [GOC:ai]"}
{"concept_id": "C1325926", "aliases": ["negative regulation of B-cell receptor signaling pathway", "downregulation of B cell receptor signaling pathway", "negative regulation of B-cell receptor signalling pathway", "negative regulation of B-lymphocyte receptor signalling pathway", "negative regulation of B lymphocyte receptor signaling pathway", "negative regulation of B cell receptor signalling pathway", "down regulation of B cell receptor signaling pathway", "negative regulation of B-lymphocyte receptor signaling pathway", "down-regulation of B cell receptor signaling pathway", "negative regulation of B lymphocyte receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of B cell receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. [GOC:ai]"}
{"concept_id": "C1325927", "aliases": ["positive regulation of B lymphocyte receptor signaling pathway", "positive regulation of B lymphocyte receptor signalling pathway", "positive regulation of B-cell receptor signalling pathway", "positive regulation of B cell receptor signalling pathway", "upregulation of B cell receptor signaling pathway", "up regulation of B cell receptor signaling pathway", "positive regulation of B-lymphocyte receptor signaling pathway", "positive regulation of B-lymphocyte receptor signalling pathway", "positive regulation of B-cell receptor signaling pathway", "up-regulation of B cell receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of B cell receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. [GOC:ai]"}
{"concept_id": "C1325928", "aliases": ["regulation of antigen receptor mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of antigen receptor-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. [GOC:ai]"}
{"concept_id": "C1325929", "aliases": ["downregulation of antigen receptor-mediated signaling pathway", "negative regulation of antigen receptor mediated signalling pathway", "down regulation of antigen receptor-mediated signaling pathway", "down-regulation of antigen receptor-mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of antigen receptor-mediated signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. [GOC:ai]"}
{"concept_id": "C1325930", "aliases": ["negative regulation of T lymphocyte receptor signalling pathway", "negative regulation of T cell receptor signalling pathway", "negative regulation of T-cell receptor signaling pathway", "negative regulation of T-lymphocyte receptor signalling pathway", "downregulation of T cell receptor signaling pathway", "negative regulation of T-lymphocyte receptor signaling pathway", "down regulation of T cell receptor signaling pathway", "down-regulation of T cell receptor signaling pathway", "negative regulation of TCR signaling pathway", "negative regulation of T lymphocyte receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of T cell receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]"}
{"concept_id": "C1325931", "aliases": ["upregulation of antigen receptor-mediated signaling pathway", "up regulation of antigen receptor-mediated signaling pathway", "up-regulation of antigen receptor-mediated signaling pathway", "positive regulation of antigen receptor mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of antigen receptor-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. [GOC:ai]"}
{"concept_id": "C1325932", "aliases": ["up-regulation of T cell receptor signaling pathway", "positive regulation of TCR signaling pathway", "positive regulation of T cell receptor signalling pathway", "positive regulation of T-lymphocyte receptor signaling pathway", "positive regulation of T lymphocyte receptor signalling pathway", "upregulation of T cell receptor signaling pathway", "positive regulation of T-lymphocyte receptor signalling pathway", "positive regulation of T-cell receptor signaling pathway", "positive regulation of T lymphocyte receptor signaling pathway", "up regulation of T cell receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of T cell receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]"}
{"concept_id": "C1325933", "aliases": ["regulation of T-cell receptor signalling pathway", "regulation of T-lymphocyte receptor signalling pathway", "regulation of TCR signaling pathway", "regulation of T-cell receptor signaling pathway", "regulation of T lymphocyte receptor signalling pathway", "regulation of T lymphocyte receptor signaling pathway", "regulation of T-lymphocyte receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of T cell receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]"}
{"concept_id": "C1325934", "aliases": ["T-lymphocyte receptor signaling pathway", "T lymphocyte receptor signalling pathway", "T lymphocyte receptor signaling pathway", "T-lymphocyte receptor signalling pathway", "T-cell receptor signaling pathway", "TCR signaling pathway", "T cell receptor signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. [GOC:add]", "canonical_name": "T-cell receptor signalling pathway"}
{"concept_id": "C1325935", "aliases": ["dpp receptor signalling pathway", "decapentaplegic receptor signalling pathway", "dpp receptor signaling pathway"], "types": ["T044"], "canonical_name": "decapentaplegic receptor signaling pathway"}
{"concept_id": "C1325936", "aliases": [], "types": ["T044"], "canonical_name": "receptor clustering", "definition": "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]"}
{"concept_id": "C1325937", "aliases": ["follicle stimulating hormone signaling pathway", "follicle stimulating hormone signalling pathway", "follicle-stimulating hormone signalling pathway"], "types": ["T044"], "canonical_name": "follicle-stimulating hormone signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by follicle-stimulating hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:dph]"}
{"concept_id": "C1325938", "aliases": ["inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway"], "types": ["T044"], "canonical_name": "phospholipase C inhibition"}
{"concept_id": "C1325941", "aliases": ["sugar mediated signalling"], "types": ["T044"], "canonical_name": "sugar mediated signaling pathway", "definition": "The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes. [PMID:9014361]"}
{"concept_id": "C1325942", "aliases": ["chloroplast-nucleus signalling pathway"], "types": ["T044"], "canonical_name": "chloroplast-nucleus signaling pathway", "definition": "The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis. [PMID:8972595]"}
{"concept_id": "C1325943", "aliases": ["defence response signaling pathway, resistance gene-independent", "defence response signalling pathway, resistance gene-independent"], "types": ["T044"], "canonical_name": "defense response signaling pathway, resistance gene-independent"}
{"concept_id": "C1325944", "aliases": ["regulation of ethene mediated signalling pathway", "regulation of ethylene mediated signalling pathway", "regulation of ethene mediated signaling pathway", "regulation of ethylene mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of ethylene-activated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of ethylene (ethene) signal transduction. [GOC:tb]"}
{"concept_id": "C1325945", "aliases": ["negative regulation of ethene mediated signaling pathway", "down-regulation of ethylene mediated signaling pathway", "negative regulation of ethylene mediated signalling pathway", "negative regulation of ethylene mediated signaling pathway", "negative regulation of ethene mediated signalling pathway", "down regulation of ethylene mediated signaling pathway", "downregulation of ethylene mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of ethylene-activated signaling pathway", "definition": "Any process that stops or prevents ethylene (ethene) signal transduction. [GOC:tb]"}
{"concept_id": "C1325946", "aliases": ["ecdysone receptor-mediated signalling pathway"], "types": ["T044"], "canonical_name": "ecdysone receptor-mediated signaling pathway", "definition": "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex. [GOC:bf]"}
{"concept_id": "C1325947", "aliases": ["glucocorticoid receptor signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by glucocorticoid binding to its receptor. [GOC:mah]", "canonical_name": "glucocorticoid receptor signalling pathway"}
{"concept_id": "C1325948", "aliases": ["progesterone receptor signalling pathway"], "types": ["T044"], "canonical_name": "progesterone receptor signaling pathway", "definition": "The series of molecular signals initiated by progesterone binding to its receptor in the cytoplasm. [GOC:ai, GOC:mah, PMID:14744870]"}
{"concept_id": "C1325953", "aliases": ["red or far-red light signal transduction", "red or far red light signaling pathway", "red/far red light signaling pathway", "red or far-red light signalling pathway"], "types": ["T044"], "canonical_name": "red or far-red light signaling pathway", "definition": "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. [GOC:lr, GOC:mtg_far_red, GOC:sm]"}
{"concept_id": "C1325954", "aliases": ["far red light signalling pathway", "far red signaling pathway", "far-red light signal transduction"], "types": ["T044"], "canonical_name": "far-red light signaling pathway", "definition": "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. [GOC:lr, GOC:mtg_far_red, GOC:sm]"}
{"concept_id": "C1325955", "aliases": ["red light signal transduction", "red light signalling pathway", "red light phototransduction"], "types": ["T044"], "canonical_name": "red light signaling pathway", "definition": "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. [GOC:mtg_far_red, GOC:sm]"}
{"concept_id": "C1325957", "aliases": ["regulation of calcium-mediated signalling"], "types": ["T044"], "canonical_name": "regulation of calcium-mediated signaling", "definition": "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. [GOC:ai]"}
{"concept_id": "C1325958", "aliases": ["down-regulation of calcium-mediated signaling", "negative regulation of calcium-mediated signalling", "down regulation of calcium-mediated signaling", "downregulation of calcium-mediated signaling"], "types": ["T044"], "canonical_name": "negative regulation of calcium-mediated signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. [GOC:ai, PMID:11696592]"}
{"concept_id": "C1325959", "aliases": ["positive regulation of calcium-mediated signalling", "upregulation of calcium-mediated signaling", "up regulation of calcium-mediated signaling", "up-regulation of calcium-mediated signaling"], "types": ["T044"], "canonical_name": "positive regulation of calcium-mediated signaling", "definition": "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. [GOC:ai]"}
{"concept_id": "C1325960", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Rac protein signal transduction", "definition": "Any process that modulates the frequency, rate or extent of Rac protein signal transduction. [GOC:bf]"}
{"concept_id": "C1325961", "aliases": ["downregulation of Rac protein signal transduction", "down-regulation of Rac protein signal transduction", "down regulation of Rac protein signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of Rac protein signal transduction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction. [GOC:bf]"}
{"concept_id": "C1325962", "aliases": ["upregulation of Rac protein signal transduction", "up-regulation of Rac protein signal transduction", "up regulation of Rac protein signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of Rac protein signal transduction", "definition": "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction. [GOC:bf]"}
{"concept_id": "C1325963", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Rho protein signal transduction", "definition": "Any process that modulates the frequency, rate or extent of Rho protein signal transduction. [GOC:bf]"}
{"concept_id": "C1325964", "aliases": ["down-regulation of Rho protein signal transduction", "down regulation of Rho protein signal transduction", "downregulation of Rho protein signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of Rho protein signal transduction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. [GOC:bf]"}
{"concept_id": "C1325965", "aliases": ["up regulation of Rho protein signal transduction", "upregulation of Rho protein signal transduction", "up-regulation of Rho protein signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of Rho protein signal transduction", "definition": "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. [GOC:bf]"}
{"concept_id": "C1325966", "aliases": [], "types": ["T044"], "canonical_name": "regulation of signal transduction", "definition": "Any process that modulates the frequency, rate or extent of signal transduction. [GOC:sm]"}
{"concept_id": "C1325967", "aliases": ["downregulation of signal transduction", "down-regulation of signal transduction", "down regulation of signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of signal transduction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. [GOC:sm]"}
{"concept_id": "C1325968", "aliases": ["upregulation of signal transduction", "up regulation of signal transduction", "up-regulation of signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of signal transduction", "definition": "Any process that activates or increases the frequency, rate or extent of signal transduction. [GOC:sm]"}
{"concept_id": "C1325969", "aliases": ["brown adipocyte cell differentiation", "brown adipocyte differentiation"], "types": ["T043"], "canonical_name": "brown fat cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [PMID:12588810]"}
{"concept_id": "C1325970", "aliases": ["white adipocyte differentiation", "white adipocyte cell differentiation"], "types": ["T043"], "canonical_name": "white fat cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. [PMID:12508945]"}
{"concept_id": "C1325972", "aliases": ["cardioblast cell differentiation", "cardiac precursor cell differentiation"], "types": ["T043"], "canonical_name": "cardioblast differentiation", "definition": "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:go_curators]"}
{"concept_id": "C1325973", "aliases": [], "types": ["T043"], "canonical_name": "dorsal vessel aortic cell fate commitment", "definition": "The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu, PMID:12397110]"}
{"concept_id": "C1325974", "aliases": [], "types": ["T043"], "canonical_name": "cardioblast cell fate commitment", "definition": "The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:go_curators]"}
{"concept_id": "C1325975", "aliases": [], "types": ["T043"], "canonical_name": "cardioblast cell fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:go_curators]"}
{"concept_id": "C1325976", "aliases": [], "types": ["T043"], "canonical_name": "cardioblast cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:go_curators]"}
{"concept_id": "C1325978", "aliases": ["down-regulation of cardioblast cell fate specification", "suppression of cardioblast cell fate", "down regulation of cardioblast cell fate specification", "downregulation of cardioblast cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of cardioblast cell fate specification", "definition": "Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:go_curators]"}
{"concept_id": "C1325979", "aliases": [], "types": ["T043"], "canonical_name": "dorsal vessel heart proper cell fate commitment", "definition": "The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu, PMID:12397110]"}
{"concept_id": "C1325980", "aliases": [], "types": ["T043"], "canonical_name": "pericardial cell differentiation"}
{"concept_id": "C1325983", "aliases": [], "types": ["T043"], "canonical_name": "retinal cone cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators]"}
{"concept_id": "C1325984", "aliases": [], "types": ["T043"], "canonical_name": "glial cell fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1325986", "aliases": [], "types": ["T043"], "canonical_name": "leading edge cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:bf]"}
{"concept_id": "C1325987", "aliases": [], "types": ["T043"], "canonical_name": "dorsal closure, leading edge cell fate determination", "definition": "The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:bf, GOC:go_curators, PMID:12147138]"}
{"concept_id": "C1325988", "aliases": [], "types": ["T043"], "canonical_name": "muscle cell fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. [CL:0000187, GOC:go_curators]"}
{"concept_id": "C1325989", "aliases": [], "types": ["T043"], "canonical_name": "myoblast fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators]"}
{"concept_id": "C1325990", "aliases": ["oocyte cell fate determination"], "types": ["T043"], "canonical_name": "oocyte fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators]"}
{"concept_id": "C1325992", "aliases": [], "types": ["T043"], "canonical_name": "pole cell fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators]"}
{"concept_id": "C1325993", "aliases": ["tracheal epithelial cell fate determination"], "types": ["T043"], "canonical_name": "epithelial cell fate determination, open tracheal system", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11063940]"}
{"concept_id": "C1325994", "aliases": ["branch cell fate determination"], "types": ["T043"], "canonical_name": "branched duct epithelial cell fate determination, open tracheal system", "definition": "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode. [GOC:mtg_sensu, PMID:10684581]"}
{"concept_id": "C1325996", "aliases": [], "types": ["T043"], "canonical_name": "abaxial cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:mg]"}
{"concept_id": "C1326003", "aliases": ["suppression of retina cone cell fate", "downregulation of retinal cone cell fate specification", "suppression of retinal cone cell fate", "down regulation of retinal cone cell fate specification", "down-regulation of retinal cone cell fate specification", "negative regulation of retina cone cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of retinal cone cell fate specification", "definition": "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell. [GOC:go_curators]"}
{"concept_id": "C1326004", "aliases": [], "types": ["T043"], "canonical_name": "regulation of retinal cone cell fate specification", "definition": "Any process that mediates the specification of a cell into a retinal cone cell. [GOC:go_curators]"}
{"concept_id": "C1326005", "aliases": [], "types": ["T043"], "canonical_name": "retinal cone cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:go_curators]"}
{"concept_id": "C1326006", "aliases": ["regulation of ectoderm cell fate specification"], "types": ["T043"], "canonical_name": "regulation of ectodermal cell fate specification", "definition": "Any process that mediates the specification of a cell into an ectoderm cell. [GOC:go_curators]"}
{"concept_id": "C1326007", "aliases": ["down regulation of ectodermal cell fate specification", "down-regulation of ectodermal cell fate specification", "downregulation of ectodermal cell fate specification", "suppression of ectodermal cell fate", "suppression of ectoderm cell fate", "negative regulation of ectoderm cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of ectodermal cell fate specification", "definition": "Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell. [GOC:go_curators]"}
{"concept_id": "C1326008", "aliases": ["regulation of endoderm cell fate specification"], "types": ["T043"], "canonical_name": "regulation of endodermal cell fate specification", "definition": "Any process that mediates the specification of a cell into an endoderm cell. [GOC:go_curators]"}
{"concept_id": "C1326009", "aliases": ["suppression of endoderm cell fate", "down-regulation of endodermal cell fate specification", "downregulation of endodermal cell fate specification", "down regulation of endodermal cell fate specification", "suppression of endodermal cell fate", "negative regulation of endoderm cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of endodermal cell fate specification", "definition": "Any process that restricts, stops or prevents a cell from specifying into an endoderm cell. [GOC:go_curators]"}
{"concept_id": "C1326010", "aliases": [], "types": ["T043"], "canonical_name": "epidermal cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:mtg_sensu, GOC:sm]"}
{"concept_id": "C1326013", "aliases": ["suppression of hair cell fate", "suppression of auditory receptor cell fate", "negative regulation of auditory hair cell fate specification", "down regulation of auditory receptor cell fate specification", "downregulation of auditory receptor cell fate specification", "down-regulation of auditory receptor cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of auditory receptor cell fate specification", "definition": "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell. [GOC:go_curators]"}
{"concept_id": "C1326016", "aliases": [], "types": ["T043"], "canonical_name": "muscle cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [CL:0000187, GOC:go_curators]"}
{"concept_id": "C1326018", "aliases": ["down regulation of cell fate specification", "down-regulation of cell fate specification", "downregulation of cell fate specification", "suppression of cell fate"], "types": ["T043"], "canonical_name": "negative regulation of cell fate specification", "definition": "Any process that restricts, stops or prevents a cell from adopting a specific cell fate. [GOC:go_curators]"}
{"concept_id": "C1326021", "aliases": [], "types": ["T043"], "canonical_name": "inner cell mass cell fate commitment", "definition": "The cell fate commitment of precursor cells that will become inner cell mass cells. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326022", "aliases": [], "types": ["T043"], "canonical_name": "leading edge cell fate commitment", "definition": "The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet. [GOC:bf]"}
{"concept_id": "C1326023", "aliases": [], "types": ["T043"], "canonical_name": "dorsal closure, leading edge cell fate commitment", "definition": "The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis. [GOC:bf]"}
{"concept_id": "C1326024", "aliases": [], "types": ["T043"], "canonical_name": "muscle cell fate commitment", "definition": "The process in which the cellular identity of muscle cells is acquired and determined. [CL:0000187, GOC:go_curators]"}
{"concept_id": "C1326025", "aliases": [], "types": ["T043"], "canonical_name": "eye photoreceptor cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. [GOC:mtg_sensu]"}
{"concept_id": "C1326028", "aliases": ["trophectoderm cell fate commitment"], "types": ["T043"], "canonical_name": "trophectodermal cell fate commitment", "definition": "The cell fate commitment of precursor cells that will become trophectoderm cells. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326029", "aliases": [], "types": ["T043"], "canonical_name": "inner cell mass cellular morphogenesis", "definition": "The morphogenesis of cells in the inner cell mass. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326034", "aliases": ["photoreceptor development"], "types": ["T043"], "canonical_name": "photoreceptor cell morphogenesis", "definition": "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. [GOC:jid, GOC:mah]"}
{"concept_id": "C1326035", "aliases": ["trophectoderm cellular morphogenesis"], "types": ["T043"], "canonical_name": "trophectodermal cellular morphogenesis", "definition": "The morphogenesis of trophectoderm cells. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326038", "aliases": [], "types": ["T043"], "canonical_name": "retinal cone cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. [GOC:go_curators]"}
{"concept_id": "C1326039", "aliases": [], "types": ["T043"], "canonical_name": "guard cell differentiation", "definition": "The process in which a guard mother cell acquires the specialized features of a guard cell. [GOC:expert_db, GOC:tb]"}
{"concept_id": "C1326040", "aliases": ["trichome cell differentiation"], "types": ["T043"], "canonical_name": "trichome differentiation", "definition": "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana. [GOC:mtg_sensu, PMID:9367433]"}
{"concept_id": "C1326042", "aliases": ["trichome cell morphogenesis during differentiation"], "types": ["T043"], "canonical_name": "trichome morphogenesis", "definition": "The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana. [GOC:mtg_sensu, GOC:tair_curators]"}
{"concept_id": "C1326043", "aliases": [], "types": ["T043"], "canonical_name": "trichome branching", "definition": "Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana. [GOC:mtg_sensu, GOC:tair_curators]"}
{"concept_id": "C1326046", "aliases": [], "types": ["T043"], "canonical_name": "root epidermal cell differentiation", "definition": "The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast. [GOC:tb]"}
{"concept_id": "C1326047", "aliases": [], "types": ["T043"], "canonical_name": "atrichoblast differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair. [GOC:tb]"}
{"concept_id": "C1326048", "aliases": [], "types": ["T043"], "canonical_name": "atrichoblast fate specification", "definition": "The process involved in the specification of an atrichoblast. [GOC:tb]"}
{"concept_id": "C1326050", "aliases": ["down-regulation of atrichoblast fate", "downregulation of atrichoblast fate", "down regulation of atrichoblast fate"], "types": ["T043"], "canonical_name": "negative regulation of atrichoblast fate specification", "definition": "Any process that suppresses atrichoblast fate specification. [GOC:tb]"}
{"concept_id": "C1326051", "aliases": ["up-regulation of atrichoblast fate", "upregulation of atrichoblast fate", "up regulation of atrichoblast fate"], "types": ["T043"], "canonical_name": "positive regulation of atrichoblast fate specification", "definition": "Any process that induces or promotes atrichoblast fate specification. [GOC:tb]"}
{"concept_id": "C1326052", "aliases": ["trichoblast cell differentiation"], "types": ["T043"], "canonical_name": "trichoblast differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair. [GOC:tb]"}
{"concept_id": "C1326053", "aliases": [], "types": ["T043"], "canonical_name": "trichoblast fate specification", "definition": "The process involved in the specification of a trichoblast. [GOC:tb]"}
{"concept_id": "C1326055", "aliases": ["downregulation of trichoblast fate", "down regulation of trichoblast fate", "down-regulation of trichoblast fate"], "types": ["T043"], "canonical_name": "negative regulation of trichoblast fate specification", "definition": "Any process that suppresses trichoblast fate specification. [GOC:tb]"}
{"concept_id": "C1326056", "aliases": ["up-regulation of trichoblast fate", "upregulation of trichoblast fate", "up regulation of trichoblast fate"], "types": ["T043"], "canonical_name": "positive regulation of trichoblast fate specification", "definition": "Any process that induces or promotes trichoblast fate specification. [GOC:tb]"}
{"concept_id": "C1326057", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751]"}
{"concept_id": "C1326058", "aliases": [], "types": ["T043"], "canonical_name": "leading edge cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet. [GOC:bf]"}
{"concept_id": "C1326059", "aliases": [], "types": ["T043"], "canonical_name": "dorsal closure, leading edge cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure. [GOC:ai, PMID:12147138]"}
{"concept_id": "C1326060", "aliases": [], "types": ["T043"], "canonical_name": "polarized epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. [GOC:mah]"}
{"concept_id": "C1326061", "aliases": [], "types": ["T043"], "canonical_name": "regulation of polarized epithelial cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation. [GOC:mah]"}
{"concept_id": "C1326062", "aliases": ["down regulation of polarized epithelial cell differentiation", "downregulation of polarized epithelial cell differentiation", "down-regulation of polarized epithelial cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of polarized epithelial cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation. [GOC:mah]"}
{"concept_id": "C1326063", "aliases": ["up-regulation of polarized epithelial cell differentiation", "upregulation of polarized epithelial cell differentiation", "up regulation of polarized epithelial cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of polarized epithelial cell differentiation", "definition": "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation. [GOC:mah]"}
{"concept_id": "C1326064", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of epithelial cell differentiation. [GOC:mah]"}
{"concept_id": "C1326065", "aliases": ["down-regulation of epithelial cell differentiation", "downregulation of epithelial cell differentiation", "down regulation of epithelial cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of epithelial cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. [GOC:mah]"}
{"concept_id": "C1326066", "aliases": ["up regulation of epithelial cell differentiation", "upregulation of epithelial cell differentiation", "up-regulation of epithelial cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of epithelial cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. [GOC:mah]"}
{"concept_id": "C1326068", "aliases": ["mucilage metabolism"], "types": ["T044"], "canonical_name": "mucilage metabolic process", "definition": "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants. [GOC:sm]"}
{"concept_id": "C1326069", "aliases": ["mucilage synthesis", "mucilage anabolism", "mucilage biosynthesis", "mucilage formation"], "types": ["T044"], "canonical_name": "mucilage biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants. [GOC:sm]"}
{"concept_id": "C1326070", "aliases": [], "types": ["T040"], "canonical_name": "regulation of seed germination", "definition": "Any process that modulates the frequency, rate or extent of seed germination. [GOC:sm]"}
{"concept_id": "C1326071", "aliases": ["downregulation of seed germination", "down regulation of seed germination", "down-regulation of seed germination"], "types": ["T040"], "canonical_name": "negative regulation of seed germination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination. [GOC:tb]"}
{"concept_id": "C1326072", "aliases": ["up-regulation of seed germination", "up regulation of seed germination", "upregulation of seed germination"], "types": ["T040"], "canonical_name": "positive regulation of seed germination", "definition": "Any process that activates or increase the rate of seed germination. [GOC:sm]"}
{"concept_id": "C1326073", "aliases": ["neuroglia differentiation", "glia cell differentiation"], "types": ["T043"], "canonical_name": "glial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1326074", "aliases": [], "types": ["T043"], "canonical_name": "crystal cell differentiation", "definition": "The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]"}
{"concept_id": "C1326075", "aliases": [], "types": ["T043"], "canonical_name": "regulation of crystal cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of crystal cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1326076", "aliases": ["down regulation of crystal cell differentiation", "downregulation of crystal cell differentiation", "down-regulation of crystal cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of crystal cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1326077", "aliases": ["up regulation of crystal cell differentiation", "up-regulation of crystal cell differentiation", "upregulation of crystal cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of crystal cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1326078", "aliases": [], "types": ["T043"], "canonical_name": "inner cell mass cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326079", "aliases": ["NK cell differentiation"], "types": ["T043"], "canonical_name": "natural killer cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1326080", "aliases": [], "types": ["T043"], "canonical_name": "muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. [CL:0000187, GOC:go_curators]"}
{"concept_id": "C1326082", "aliases": ["granulocyte cell differentiation"], "types": ["T043"], "definition": "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm]", "canonical_name": "granulocyte differentiation"}
{"concept_id": "C1326083", "aliases": [], "types": ["T043"], "canonical_name": "regulation of granulocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of granulocyte differentiation. [GOC:mah]"}
{"concept_id": "C1326084", "aliases": ["down-regulation of granulocyte differentiation", "downregulation of granulocyte differentiation", "down regulation of granulocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of granulocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation. [GOC:mah]"}
{"concept_id": "C1326085", "aliases": ["up-regulation of granulocyte differentiation", "upregulation of granulocyte differentiation", "up regulation of granulocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of granulocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation. [GOC:mah]"}
{"concept_id": "C1326086", "aliases": ["oenocyte cell differentiation"], "types": ["T043"], "canonical_name": "oenocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments. [GOC:go_curators]"}
{"concept_id": "C1326087", "aliases": ["oocyte cell differentiation"], "types": ["T043"], "canonical_name": "oocyte differentiation", "definition": "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1326088", "aliases": [], "types": ["T043"], "canonical_name": "germarium-derived oocyte differentiation", "definition": "The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1326089", "aliases": [], "types": ["T042"], "canonical_name": "eye photoreceptor cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. [GOC:go_curators]"}
{"concept_id": "C1326095", "aliases": ["pigmented cell differentiation", "chromatophore differentiation"], "types": ["T043"], "canonical_name": "pigment cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. [GOC:dgh]"}
{"concept_id": "C1326096", "aliases": ["iridophore cell differentiation"], "types": ["T043"], "canonical_name": "iridophore differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance. [GOC:jid, GOC:mh, PMID:11858836]"}
{"concept_id": "C1326097", "aliases": [], "types": ["T043"], "canonical_name": "regulation of iridophore differentiation", "definition": "Any process that modulates the frequency, rate or extent of iridophore differentiation. [GOC:ai]"}
{"concept_id": "C1326098", "aliases": ["down-regulation of iridophore differentiation", "downregulation of iridophore differentiation", "down regulation of iridophore differentiation"], "types": ["T043"], "canonical_name": "negative regulation of iridophore differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation. [GOC:ai]"}
{"concept_id": "C1326099", "aliases": ["up-regulation of iridophore differentiation", "up regulation of iridophore differentiation", "upregulation of iridophore differentiation"], "types": ["T043"], "canonical_name": "positive regulation of iridophore differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of iridophore differentiation. [GOC:ai]"}
{"concept_id": "C1326100", "aliases": ["early stripe melanophore differentiation", "early stripe melanocyte cell differentiation"], "types": ["T043"], "canonical_name": "early stripe melanocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development). [PMID:11858836]"}
{"concept_id": "C1326101", "aliases": ["regulation of early stripe melanophore differentiation"], "types": ["T043"], "canonical_name": "regulation of early stripe melanocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation. [GOC:ai]"}
{"concept_id": "C1326102", "aliases": ["down regulation of early stripe melanocyte differentiation", "negative regulation of early stripe melanophore differentiation", "down-regulation of early stripe melanocyte differentiation", "downregulation of early stripe melanocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of early stripe melanocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of early stripe melanocyte differentiation. [GOC:ai]"}
{"concept_id": "C1326103", "aliases": ["upregulation of early stripe melanocyte differentiation", "positive regulation of early stripe melanophore differentiation", "up regulation of early stripe melanocyte differentiation", "up-regulation of early stripe melanocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of early stripe melanocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation. [GOC:ai]"}
{"concept_id": "C1326104", "aliases": ["late stripe melanophore differentiation", "late stripe melanocyte cell differentiation"], "types": ["T043"], "canonical_name": "late stripe melanocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development). [PMID:11858836]"}
{"concept_id": "C1326105", "aliases": ["regulation of late stripe melanophore differentiation"], "types": ["T043"], "canonical_name": "regulation of late stripe melanocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation. [GOC:ai]"}
{"concept_id": "C1326106", "aliases": ["negative regulation of late stripe melanophore differentiation", "down regulation of late stripe melanocyte differentiation", "down-regulation of late stripe melanocyte differentiation", "downregulation of late stripe melanocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of late stripe melanocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of late stripe melanocyte differentiation. [GOC:ai]"}
{"concept_id": "C1326107", "aliases": ["up regulation of late stripe melanocyte differentiation", "upregulation of late stripe melanocyte differentiation", "up-regulation of late stripe melanocyte differentiation", "positive regulation of late stripe melanophore differentiation"], "types": ["T043"], "canonical_name": "positive regulation of late stripe melanocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation. [GOC:ai]"}
{"concept_id": "C1326108", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pigment cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of pigmented cell differentiation. [GOC:ai]"}
{"concept_id": "C1326109", "aliases": ["down-regulation of pigment cell differentiation", "down regulation of pigment cell differentiation", "downregulation of pigment cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of pigment cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. [GOC:ai]"}
{"concept_id": "C1326110", "aliases": ["downregulation of xanthophore differentiation", "down regulation of xanthophore differentiation", "down-regulation of xanthophore differentiation"], "types": ["T043"], "canonical_name": "negative regulation of xanthophore differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of xanthophore differentiation. [GOC:ai]"}
{"concept_id": "C1326111", "aliases": ["up-regulation of pigment cell differentiation", "upregulation of pigment cell differentiation", "up regulation of pigment cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of pigment cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. [GOC:ai]"}
{"concept_id": "C1326112", "aliases": ["upregulation of xanthophore differentiation", "up-regulation of xanthophore differentiation", "up regulation of xanthophore differentiation"], "types": ["T043"], "canonical_name": "positive regulation of xanthophore differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation. [GOC:ai]"}
{"concept_id": "C1326113", "aliases": [], "types": ["T043"], "canonical_name": "regulation of xanthophore differentiation", "definition": "Any process that modulates the frequency, rate or extent of xanthophore differentiation. [GOC:ai]"}
{"concept_id": "C1326114", "aliases": ["xanthophore cell differentiation"], "types": ["T043"], "canonical_name": "xanthophore differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance. [GOC:jid, GOC:mh, PMID:11858836]"}
{"concept_id": "C1326115", "aliases": [], "types": ["T043"], "canonical_name": "sperm axoneme assembly", "definition": "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement. [GOC:bf, GOC:cilia, ISBN:0198547684]"}
{"concept_id": "C1326116", "aliases": ["sperm chromatin condensation"], "types": ["T045"], "canonical_name": "sperm DNA condensation", "definition": "The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication. [GOC:bf, PMID:11735001]"}
{"concept_id": "C1326118", "aliases": ["trophectoderm cell differentiation"], "types": ["T043"], "canonical_name": "trophectodermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326120", "aliases": [], "types": ["T043"], "definition": "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:mgi_curators]", "canonical_name": "cell activation"}
{"concept_id": "C1326121", "aliases": [], "types": ["T043"], "canonical_name": "astrocyte activation", "definition": "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813]"}
{"concept_id": "C1326122", "aliases": [], "types": ["T043"], "canonical_name": "myeloid dendritic cell activation", "definition": "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]"}
{"concept_id": "C1326123", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myeloid dendritic cell activation", "definition": "Any process that modulates the frequency or rate of myeloid dendritic cell activation. [GOC:mah]"}
{"concept_id": "C1326124", "aliases": ["down regulation of myeloid dendritic cell activation", "down-regulation of myeloid dendritic cell activation", "downregulation of myeloid dendritic cell activation"], "types": ["T043"], "canonical_name": "negative regulation of myeloid dendritic cell activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation. [GOC:mah]"}
{"concept_id": "C1326125", "aliases": ["upregulation of myeloid dendritic cell activation", "up regulation of myeloid dendritic cell activation", "up-regulation of myeloid dendritic cell activation"], "types": ["T043"], "canonical_name": "positive regulation of myeloid dendritic cell activation", "definition": "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation. [GOC:mah]"}
{"concept_id": "C1326126", "aliases": ["leukocyte adhesive triggering"], "types": ["T043"], "canonical_name": "leukocyte adhesive activation", "definition": "The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation. [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]"}
{"concept_id": "C1326127", "aliases": ["regulation of B-lymphocyte proliferation", "regulation of B lymphocyte proliferation", "regulation of B-cell proliferation"], "types": ["T043"], "canonical_name": "regulation of B cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of B cell proliferation. [GOC:mah]"}
{"concept_id": "C1326128", "aliases": ["negative regulation of B-lymphocyte proliferation", "downregulation of B cell proliferation", "negative regulation of B lymphocyte proliferation", "down regulation of B cell proliferation", "down-regulation of B cell proliferation", "negative regulation of B-cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of B cell proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of B cell proliferation. [GOC:mah]"}
{"concept_id": "C1326129", "aliases": ["positive regulation of B-cell proliferation", "positive regulation of B lymphocyte proliferation", "upregulation of B cell proliferation", "positive regulation of B-lymphocyte proliferation", "up-regulation of B cell proliferation", "up regulation of B cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of B cell proliferation", "definition": "Any process that activates or increases the rate or extent of B cell proliferation. [GOC:mah]"}
{"concept_id": "C1326130", "aliases": ["establishment of B-lymphocyte polarity", "establishment of B lymphocyte polarity", "B cell polarization", "establishment of B-cell polarity", "B lymphocyte polarization", "B-cell polarization"], "types": ["T043"], "canonical_name": "establishment of B cell polarity", "definition": "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell. [GOC:mgi_curators, PMID:12615889, PMID:9692889]"}
{"concept_id": "C1326131", "aliases": ["isotype switch recombination to IgA isotypes", "class switching to IgA isotypes"], "types": ["T045"], "canonical_name": "isotype switching to IgA isotypes", "definition": "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus. [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]"}
{"concept_id": "C1326132", "aliases": ["regulation of class switch recombination to IgA isotypes", "regulation of class switching to IgA isotypes", "regulation of isotype switch recombination to IgA isotypes"], "types": ["T045"], "canonical_name": "regulation of isotype switching to IgA isotypes", "definition": "Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes. [GOC:jid]"}
{"concept_id": "C1326133", "aliases": ["down-regulation of isotype switching to IgA isotypes", "downregulation of isotype switching to IgA isotypes", "negative regulation of isotype switch recombination to IgA isotypes", "negative regulation of class switching to IgA isotypes", "negative regulation of class switch recombination to IgA isotypes", "down regulation of isotype switching to IgA isotypes"], "types": ["T044"], "canonical_name": "negative regulation of isotype switching to IgA isotypes", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgA isotypes. [GOC:jid]"}
{"concept_id": "C1326134", "aliases": ["positive regulation of class switching to IgA isotypes", "up-regulation of isotype switching to IgA isotypes", "positive regulation of class switch recombination to IgA isotypes", "up regulation of isotype switching to IgA isotypes", "positive regulation of isotype switch recombination to IgA isotypes", "upregulation of isotype switching to IgA isotypes"], "types": ["T045"], "canonical_name": "positive regulation of isotype switching to IgA isotypes", "definition": "Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes. [GOC:jid]"}
{"concept_id": "C1326135", "aliases": ["class switching to IgD isotypes", "isotype switch recombination to IgD isotypes"], "types": ["T045"], "canonical_name": "isotype switching to IgD isotypes", "definition": "The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus. [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]"}
{"concept_id": "C1326136", "aliases": ["regulation of isotype switch recombination to IgD isotypes", "regulation of class switch recombination to IgD isotypes", "regulation of class switching to IgD isotypes"], "types": ["T045"], "canonical_name": "regulation of isotype switching to IgD isotypes", "definition": "Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes. [GOC:jid]"}
{"concept_id": "C1326137", "aliases": ["negative regulation of class switch recombination to IgD isotypes", "down regulation of isotype switching to IgD isotypes", "down-regulation of isotype switching to IgD isotypes", "negative regulation of isotype switch recombination to IgD isotypes", "downregulation of isotype switching to IgD isotypes", "negative regulation of class switching to IgD isotypes"], "types": ["T045"], "canonical_name": "negative regulation of isotype switching to IgD isotypes", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgD isotypes. [GOC:jid]"}
{"concept_id": "C1326138", "aliases": ["up regulation of isotype switching to IgD isotypes", "positive regulation of class switching to IgD isotypes", "upregulation of isotype switching to IgD isotypes", "up-regulation of isotype switching to IgD isotypes", "positive regulation of isotype switch recombination to IgD isotypes", "positive regulation of class switch recombination to IgD isotypes"], "types": ["T045"], "canonical_name": "positive regulation of isotype switching to IgD isotypes", "definition": "Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes. [GOC:jid]"}
{"concept_id": "C1326139", "aliases": ["class switching to IgE isotypes", "isotype switch recombination to IgE isotypes", "class switch recombination to IgE isotypes"], "types": ["T045"], "canonical_name": "isotype switching to IgE isotypes", "definition": "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus. [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]"}
{"concept_id": "C1326140", "aliases": ["regulation of isotype switch recombination to IgE isotypes", "regulation of class switch recombination to IgE isotypes", "regulation of class switching to IgE isotypes"], "types": ["T045"], "canonical_name": "regulation of isotype switching to IgE isotypes", "definition": "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes. [GOC:jid]"}
{"concept_id": "C1326141", "aliases": ["negative regulation of isotype switch recombination to IgE isotypes", "negative regulation of class switching to IgE isotypes", "down-regulation of isotype switching to IgE isotypes", "downregulation of isotype switching to IgE isotypes", "down regulation of isotype switching to IgE isotypes", "negative regulation of class switch recombination to IgE isotypes"], "types": ["T044"], "canonical_name": "negative regulation of isotype switching to IgE isotypes", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes. [GOC:jid]"}
{"concept_id": "C1326142", "aliases": ["up-regulation of isotype switching to IgE isotypes", "positive regulation of class switching to IgE isotypes", "upregulation of isotype switching to IgE isotypes", "up regulation of isotype switching to IgE isotypes", "positive regulation of class switch recombination to IgE isotypes", "positive regulation of isotype switch recombination to IgE isotypes"], "types": ["T045"], "canonical_name": "positive regulation of isotype switching to IgE isotypes", "definition": "Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes. [GOC:jid]"}
{"concept_id": "C1326143", "aliases": ["class switching to IgG isotypes", "isotype switch recombination to IgG isotypes"], "types": ["T045"], "canonical_name": "isotype switching to IgG isotypes", "definition": "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus. [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]"}
{"concept_id": "C1326144", "aliases": ["regulation of isotype switch recombination to IgG isotypes", "regulation of class switching to IgG isotypes", "regulation of class switch recombination to IgG isotypes"], "types": ["T044"], "canonical_name": "regulation of isotype switching to IgG isotypes", "definition": "Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes. [GOC:jid]"}
{"concept_id": "C1326145", "aliases": ["negative regulation of class switching to IgG isotypes", "down-regulation of isotype switching to IgG isotypes", "negative regulation of isotype switch recombination to IgG isotypes", "downregulation of isotype switching to IgG isotypes", "negative regulation of class switch recombination to IgG isotypes", "down regulation of isotype switching to IgG isotypes"], "types": ["T045"], "canonical_name": "negative regulation of isotype switching to IgG isotypes", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgG isotypes. [GOC:jid]"}
{"concept_id": "C1326146", "aliases": ["up-regulation of isotype switching to IgG isotypes", "upregulation of isotype switching to IgG isotypes", "positive regulation of class switch recombination to IgG isotypes", "positive regulation of class switching to IgG isotypes", "up regulation of isotype switching to IgG isotypes", "positive regulation of isotype switch recombination to IgG isotypes"], "types": ["T045"], "canonical_name": "positive regulation of isotype switching to IgG isotypes", "definition": "Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes. [GOC:jid]"}
{"concept_id": "C1326147", "aliases": ["regulation of B-cell activation", "regulation of B lymphocyte activation", "regulation of B-lymphocyte activation"], "types": ["T043"], "canonical_name": "regulation of B cell activation", "definition": "Any process that modulates the frequency, rate or extent of B cell activation. [GOC:ai]"}
{"concept_id": "C1326148", "aliases": ["down regulation of B cell activation", "negative regulation of B lymphocyte activation", "negative regulation of B-cell activation", "downregulation of B cell activation", "negative regulation of B-lymphocyte activation", "down-regulation of B cell activation"], "types": ["T043"], "canonical_name": "negative regulation of B cell activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. [GOC:ai]"}
{"concept_id": "C1326149", "aliases": ["positive regulation of B lymphocyte activation", "up-regulation of B cell activation", "up regulation of B cell activation", "positive regulation of B-cell activation", "upregulation of B cell activation", "positive regulation of B-lymphocyte activation"], "types": ["T043"], "canonical_name": "positive regulation of B cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of B cell activation. [GOC:ai]"}
{"concept_id": "C1326150", "aliases": ["lymphocyte polarization"], "types": ["T043"], "canonical_name": "establishment of lymphocyte polarity", "definition": "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell. [GOC:mgi_curators, PMID:11244041, PMID:12615889]"}
{"concept_id": "C1326151", "aliases": ["NK cell polarization", "natural killer cell polarization", "establishment of NK cell polarity"], "types": ["T043"], "canonical_name": "establishment of natural killer cell polarity", "definition": "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands. [GOC:mgi_curators, PMID:12615886, PMID:9759849]"}
{"concept_id": "C1326152", "aliases": ["T lymphocyte polarization", "establishment of T-cell polarity", "T cell polarization", "establishment of T lymphocyte polarity", "establishment of T-lymphocyte polarity", "T-cell polarization"], "types": ["T043"], "canonical_name": "establishment of T cell polarity", "definition": "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. [GOC:mgi_curators, PMID:11244041, PMID:12615889]"}
{"concept_id": "C1326153", "aliases": ["formation of immunological synapse"], "types": ["T043"], "canonical_name": "immunological synapse formation", "definition": "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [GOC:mgi_curators, PMID:11244041, PMID:11376330]"}
{"concept_id": "C1326154", "aliases": ["NK cell proliferation"], "types": ["T043"], "canonical_name": "natural killer cell proliferation", "definition": "The expansion of a natural killer cell population by cell division. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1326155", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lymphocyte proliferation", "definition": "Any process that modulates the frequency, rate or extent of lymphocyte proliferation. [GOC:ai]"}
{"concept_id": "C1326156", "aliases": ["downregulation of lymphocyte proliferation", "down regulation of lymphocyte proliferation", "down-regulation of lymphocyte proliferation"], "types": ["T043"], "canonical_name": "negative regulation of lymphocyte proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. [GOC:ai]"}
{"concept_id": "C1326157", "aliases": ["up regulation of lymphocyte proliferation", "upregulation of lymphocyte proliferation", "up-regulation of lymphocyte proliferation"], "types": ["T043"], "canonical_name": "positive regulation of lymphocyte proliferation", "definition": "Any process that activates or increases the rate or extent of lymphocyte proliferation. [GOC:ai]"}
{"concept_id": "C1326158", "aliases": ["up-regulation of epithelial cell proliferation", "up regulation of epithelial cell proliferation", "upregulation of epithelial cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of epithelial cell proliferation", "definition": "Any process that activates or increases the rate or extent of epithelial cell proliferation. [GOC:ai]"}
{"concept_id": "C1326159", "aliases": ["up-regulation of urothelial cell proliferation", "up regulation of urothelial cell proliferation", "upregulation of urothelial cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of urothelial cell proliferation", "definition": "Any process that activates or increases the rate or extent of urothelial cell proliferation. [GOC:ai]"}
{"concept_id": "C1326160", "aliases": ["activated T-cell proliferation", "proliferation of activated T cells", "activated T lymphocyte proliferation", "activated T-lymphocyte proliferation"], "types": ["T043"], "canonical_name": "activated T cell proliferation", "definition": "The expansion of a T cell population following activation by an antigenic stimulus. [GOC:add, GOC:dph]"}
{"concept_id": "C1326161", "aliases": ["resting T cell proliferation", "T-lymphocyte homeostatic proliferation", "resting T-cell proliferation", "T lymphocyte homeostatic proliferation", "T-cell homeostatic proliferation"], "types": ["T043"], "canonical_name": "T cell homeostatic proliferation", "definition": "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus. [GOC:mgi_curators, ISBN:0781735149]"}
{"concept_id": "C1326162", "aliases": ["alpha-beta T-cell activation by superantigen", "alpha-beta T lymphocyte activation by superantigen", "alpha-beta T-lymphocyte activation by superantigen"], "types": ["T043"], "canonical_name": "alpha-beta T cell activation by superantigen", "definition": "The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region. [GOC:jl]"}
{"concept_id": "C1326163", "aliases": ["regulation of T-cell activation", "regulation of T lymphocyte activation", "regulation of T-lymphocyte activation"], "types": ["T043"], "canonical_name": "regulation of T cell activation", "definition": "Any process that modulates the frequency, rate or extent of T cell activation. [GOC:ai]"}
{"concept_id": "C1326164", "aliases": ["negative regulation of T-lymphocyte activation", "downregulation of T cell activation", "down-regulation of T cell activation", "down regulation of T cell activation", "negative regulation of T-cell activation", "negative regulation of T lymphocyte activation"], "types": ["T043"], "canonical_name": "negative regulation of T cell activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. [GOC:ai]"}
{"concept_id": "C1326165", "aliases": ["positive regulation of T lymphocyte activation", "up-regulation of T cell activation", "positive regulation of T-lymphocyte activation", "upregulation of T cell activation", "up regulation of T cell activation", "positive regulation of T-cell activation"], "types": ["T043"], "canonical_name": "positive regulation of T cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of T cell activation. [GOC:ai]"}
{"concept_id": "C1326166", "aliases": ["regulation of macrophage polarization"], "types": ["T043"], "canonical_name": "regulation of macrophage activation", "definition": "Any process that modulates the frequency or rate of macrophage activation. [GOC:jl]"}
{"concept_id": "C1326167", "aliases": ["down regulation of macrophage activation", "down-regulation of macrophage activation", "downregulation of macrophage activation", "negative regulation of macrophage polarization"], "types": ["T043"], "canonical_name": "negative regulation of macrophage activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. [GOC:jl]"}
{"concept_id": "C1326168", "aliases": ["up regulation of macrophage activation", "upregulation of macrophage activation", "up-regulation of macrophage activation", "positive regulation of macrophage polarization"], "types": ["T043"], "canonical_name": "positive regulation of macrophage activation", "definition": "Any process that stimulates, induces or increases the rate of macrophage activation. [GOC:jl]"}
{"concept_id": "C1326169", "aliases": [], "types": ["T043"], "canonical_name": "microglial cell activation", "definition": "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949]"}
{"concept_id": "C1326170", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell activation", "definition": "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:ai]"}
{"concept_id": "C1326171", "aliases": ["downregulation of cell activation", "down regulation of cell activation", "down-regulation of cell activation"], "types": ["T043"], "canonical_name": "negative regulation of cell activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. [GOC:ai]"}
{"concept_id": "C1326172", "aliases": ["upregulation of cell activation", "up regulation of cell activation", "up-regulation of cell activation"], "types": ["T043"], "canonical_name": "positive regulation of cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of activation. [GOC:ai]"}
{"concept_id": "C1326197", "aliases": ["regulation of antibody-dependent cell killing", "regulation of antibody-dependent cell death", "regulation of antibody dependent cell death", "regulation of antibody dependent cell killing"], "types": ["T043"], "canonical_name": "regulation of antibody-dependent cellular cytotoxicity", "definition": "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1326198", "aliases": ["down regulation of antibody-dependent cellular cytotoxicity", "negative regulation of antibody dependent cell killing", "downregulation of antibody-dependent cellular cytotoxicity", "down-regulation of antibody-dependent cellular cytotoxicity", "negative regulation of antibody-dependent cell killing", "negative regulation of antibody-dependent cell death", "negative regulation of antibody dependent cell death"], "types": ["T043"], "canonical_name": "negative regulation of antibody-dependent cellular cytotoxicity", "definition": "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1326199", "aliases": ["positive regulation of antibody dependent cell killing", "positive regulation of antibody-dependent cell killing", "positive regulation of antibody-dependent cell death", "up regulation of antibody-dependent cellular cytotoxicity", "upregulation of antibody-dependent cellular cytotoxicity", "positive regulation of antibody dependent cell death", "up-regulation of antibody-dependent cellular cytotoxicity"], "types": ["T043"], "canonical_name": "positive regulation of antibody-dependent cellular cytotoxicity", "definition": "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1326200", "aliases": [], "types": ["T043"], "canonical_name": "release of cytochrome c from mitochondria", "definition": "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217]"}
{"concept_id": "C1326202", "aliases": ["B lymphocyte apoptosis", "programmed cell death, B lymphocytes", "apoptosis of B-lymphocytes", "programmed cell death of B-lymphocytes by apoptosis", "programmed cell death of B cells by apoptosis", "apoptosis of B-cells", "B cell programmed cell death by apoptosis", "B-cell programmed cell death by apoptosis", "programmed cell death, B cells", "B-cell apoptosis", "B-lymphocyte apoptosis", "programmed cell death of B lymphocytes by apoptosis", "B cell apoptosis", "apoptosis of B cells", "programmed cell death of B-cells by apoptosis", "B-lymphocyte programmed cell death by apoptosis", "apoptosis of B lymphocytes", "B lymphocyte programmed cell death by apoptosis", "programmed cell death, B-cells", "programmed cell death, B-lymphocytes"], "types": ["T043"], "canonical_name": "B cell apoptotic process", "definition": "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]"}
{"concept_id": "C1326205", "aliases": ["up regulation of apoptosis", "positive regulation of apoptotic process", "induction of apoptosis", "up-regulation of apoptosis", "upregulation of apoptosis"], "types": ["T043"], "definition": "Any cellular process that increases the frequency, rate or extent of cell death by apoptosis.", "canonical_name": "positive regulation of apoptosis"}
{"concept_id": "C1326206", "aliases": [], "types": ["T044"], "canonical_name": "DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C1326207", "aliases": ["programmed cell death by autophagy", "type II programmed cell death", "non-apoptotic programmed cell death", "autophagic death", "autophagic cell death"], "types": ["T043"], "definition": "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells. [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517]", "canonical_name": "programmed cell death by macroautophagy"}
{"concept_id": "C1326208", "aliases": ["programmed cell death of larval midgut cells", "larval midgut cell death"], "types": ["T043"], "canonical_name": "larval midgut cell programmed cell death", "definition": "The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ. [GOC:bf, GOC:mtg_apoptosis]"}
{"concept_id": "C1326209", "aliases": [], "types": ["T043"], "canonical_name": "regulation of non-apoptotic programmed cell death"}
{"concept_id": "C1326210", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of non-apoptotic programmed cell death"}
{"concept_id": "C1326211", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of non-apoptotic programmed cell death"}
{"concept_id": "C1326212", "aliases": ["programmed cell death of neutrophils by apoptosis", "neutrophil programmed cell death by apoptosis", "apoptosis of neutrophils", "programmed cell death, neutrophils", "neutrophil apoptosis"], "types": ["T043"], "canonical_name": "neutrophil apoptotic process", "definition": "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266]"}
{"concept_id": "C1326213", "aliases": [], "types": ["T043"], "canonical_name": "regulation of programmed cell death", "definition": "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. [GOC:jl]"}
{"concept_id": "C1326214", "aliases": ["down-regulation of programmed cell death", "downregulation of programmed cell death", "down regulation of programmed cell death"], "types": ["T043"], "canonical_name": "negative regulation of programmed cell death", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. [GOC:jl]"}
{"concept_id": "C1326215", "aliases": ["upregulation of programmed cell death", "up-regulation of programmed cell death", "up regulation of programmed cell death"], "types": ["T043"], "canonical_name": "positive regulation of programmed cell death", "definition": "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. [GOC:jl]"}
{"concept_id": "C1326216", "aliases": [], "types": ["T043"], "canonical_name": "induction of programmed cell death by hormones", "definition": "Any process induced by hormones that directly activates any of the steps required for programmed cell death. [GOC:bf]"}
{"concept_id": "C1326217", "aliases": [], "types": ["T043"], "canonical_name": "induction of programmed cell death by ecdysone", "definition": "Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death. [GOC:bf]"}
{"concept_id": "C1326219", "aliases": ["programmed cell death of salivary gland cells by autophagy", "salivary gland cell programmed cell death by autophagy", "salivary gland cell death", "autophagic cell death of salivary gland cells"], "types": ["T043"], "canonical_name": "salivary gland cell autophagic cell death", "definition": "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis. [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]"}
{"concept_id": "C1326220", "aliases": ["synergid cell death", "synergid degeneration"], "types": ["T043"], "canonical_name": "synergid death", "definition": "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles. [GOC:isa_complete, GOC:sm, PMID:12215516]"}
{"concept_id": "C1326221", "aliases": ["bipolar growth", "bipolar cell elongation"], "types": ["T043"], "canonical_name": "bipolar cell growth", "definition": "The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell. [GOC:vw]"}
{"concept_id": "C1326222", "aliases": [], "types": ["T043"], "canonical_name": "monopolar cell growth", "definition": "Polarized growth from one end of a cell. [GOC:vw]"}
{"concept_id": "C1326223", "aliases": ["polar cell elongation"], "types": ["T043"], "canonical_name": "polar cell elongation", "definition": "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion. [PMID:11978864]"}
{"concept_id": "C1326224", "aliases": [], "types": ["T043"], "canonical_name": "oocyte growth in germarium-derived egg chamber", "definition": "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1326226", "aliases": [], "types": ["T043"], "canonical_name": "cellular transition metal ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1326227", "aliases": ["immune cell homeostasis", "leucocyte homeostasis"], "types": ["T043"], "canonical_name": "leukocyte homeostasis", "definition": "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1326228", "aliases": ["B-cell homeostasis", "B-lymphocyte homeostasis", "B lymphocyte homeostasis"], "types": ["T043"], "canonical_name": "B cell homeostasis", "definition": "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, ISBN:0781735149, PMID:12956429]"}
{"concept_id": "C1326229", "aliases": [], "types": ["T043"], "canonical_name": "neutrophil homeostasis", "definition": "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, GOC:pr, PMID:12752675, PMID:12960266]"}
{"concept_id": "C1326230", "aliases": ["T-lymphocyte homeostasis", "T lymphocyte homeostasis", "T-cell homeostasis"], "types": ["T043"], "canonical_name": "T cell homeostasis", "definition": "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:mgi_curators, ISBN:0781735149]"}
{"concept_id": "C1326231", "aliases": [], "types": ["T043"], "canonical_name": "cellular osmoregulation"}
{"concept_id": "C1326232", "aliases": [], "types": ["T043"], "canonical_name": "axoneme biogenesis"}
{"concept_id": "C1326233", "aliases": [], "types": ["T043"], "canonical_name": "cilium axoneme biogenesis"}
{"concept_id": "C1326235", "aliases": [], "types": ["T043"], "canonical_name": "sensory cilium biogenesis"}
{"concept_id": "C1326236", "aliases": ["filopodia formation", "filopodium formation", "filopodia biosynthesis"], "types": ["T043"], "canonical_name": "filopodium assembly", "definition": "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]"}
{"concept_id": "C1326238", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of apical/basal cell polarity", "definition": "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. [GOC:bf, GOC:mah, PMID:10934483]"}
{"concept_id": "C1326239", "aliases": [], "types": ["T043"], "canonical_name": "establishment of apical/basal cell polarity", "definition": "The specification and formation of the polarity of a cell along its apical/basal axis. [GOC:bf]"}
{"concept_id": "C1326240", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of apical/basal cell polarity", "definition": "Retaining the established polarization of a cell along its apical/basal axis. [GOC:bf]"}
{"concept_id": "C1326241", "aliases": [], "types": ["T043"], "canonical_name": "invasive growth in response to glucose limitation", "definition": "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae. [GOC:mcc, PMID:9728395]"}
{"concept_id": "C1326242", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction during filamentous growth"}
{"concept_id": "C1326243", "aliases": ["clathrin cage assembly"], "types": ["T043"], "canonical_name": "clathrin coat assembly", "definition": "The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549]"}
{"concept_id": "C1326244", "aliases": ["clathrin coating of Golgi-derived vesicle"], "types": ["T043"], "canonical_name": "clathrin coating of Golgi vesicle", "definition": "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326245", "aliases": ["regulation of actin depolymerization"], "types": ["T043"], "canonical_name": "regulation of actin filament depolymerization", "definition": "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament. [GOC:mah]"}
{"concept_id": "C1326246", "aliases": ["negative regulation of actin depolymerization", "down regulation of actin filament depolymerization", "down-regulation of actin filament depolymerization", "downregulation of actin filament depolymerization", "actin filament stabilization"], "types": ["T043"], "canonical_name": "negative regulation of actin filament depolymerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. [GOC:mah]"}
{"concept_id": "C1326247", "aliases": ["upregulation of actin filament depolymerization", "positive regulation of actin depolymerization", "up-regulation of actin filament depolymerization", "actin filament destabilization", "up regulation of actin filament depolymerization"], "types": ["T043"], "canonical_name": "positive regulation of actin filament depolymerization", "definition": "Any process that activates or increases the frequency, rate or extent of actin depolymerization. [GOC:mah]"}
{"concept_id": "C1326248", "aliases": ["regulation of actin polymerization"], "types": ["T043"], "canonical_name": "regulation of actin filament polymerization", "definition": "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. [GOC:mah]"}
{"concept_id": "C1326249", "aliases": ["negative regulation of actin polymerization", "down regulation of actin filament polymerization", "downregulation of actin filament polymerization", "down-regulation of actin filament polymerization"], "types": ["T043"], "canonical_name": "negative regulation of actin filament polymerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. [GOC:mah]"}
{"concept_id": "C1326250", "aliases": ["retention of actin monomers", "actin monomer sequestration", "actin monomer sequestering", "actin monomer storage", "actin monomer retention", "sequestration of actin monomers", "storage of actin monomers"], "types": ["T043"], "canonical_name": "sequestering of actin monomers", "definition": "The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers. [GOC:go_curators]"}
{"concept_id": "C1326251", "aliases": ["upregulation of actin filament polymerization", "up-regulation of actin filament polymerization", "positive regulation of actin polymerization", "up regulation of actin filament polymerization"], "types": ["T043"], "canonical_name": "positive regulation of actin filament polymerization", "definition": "Any process that activates or increases the frequency, rate or extent of actin polymerization. [GOC:mah]"}
{"concept_id": "C1326252", "aliases": ["cortical actin cytoskeleton organisation", "actin cortex stabilization", "cortical actin cytoskeleton stabilization", "cortical actin cytoskeleton organization and biogenesis"], "types": ["T043"], "canonical_name": "cortical actin cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. [GOC:dph, GOC:jl, GOC:mah, GOC:pf]"}
{"concept_id": "C1326254", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament length", "definition": "Any process that controls the length of actin filaments in a cell. [GOC:dph, GOC:mah]"}
{"concept_id": "C1326255", "aliases": ["cortical cytoskeleton organization and biogenesis", "cortical cytoskeleton organisation"], "types": ["T043"], "canonical_name": "cortical cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1326256", "aliases": [], "types": ["T043"], "canonical_name": "establishment of planar cell polarity"}
{"concept_id": "C1326260", "aliases": ["establishment of wing hair orientation"], "types": ["T042"], "canonical_name": "establishment of imaginal disc-derived wing hair orientation", "definition": "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction. [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]"}
{"concept_id": "C1326261", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intermediate filament depolymerization", "definition": "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament. [GOC:mah]"}
{"concept_id": "C1326262", "aliases": ["downregulation of intermediate filament depolymerization", "down regulation of intermediate filament depolymerization", "down-regulation of intermediate filament depolymerization"], "types": ["T043"], "canonical_name": "negative regulation of intermediate filament depolymerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization. [GOC:mah]"}
{"concept_id": "C1326263", "aliases": ["up regulation of intermediate filament depolymerization", "up-regulation of intermediate filament depolymerization", "upregulation of intermediate filament depolymerization"], "types": ["T043"], "canonical_name": "positive regulation of intermediate filament depolymerization", "definition": "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization. [GOC:mah]"}
{"concept_id": "C1326264", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intermediate filament polymerization", "definition": "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament. [GOC:mah]"}
{"concept_id": "C1326265", "aliases": ["down regulation of intermediate filament polymerization", "downregulation of intermediate filament polymerization", "down-regulation of intermediate filament polymerization"], "types": ["T043"], "canonical_name": "negative regulation of intermediate filament polymerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization. [GOC:mah]"}
{"concept_id": "C1326266", "aliases": ["up regulation of intermediate filament polymerization", "upregulation of intermediate filament polymerization", "up-regulation of intermediate filament polymerization"], "types": ["T043"], "canonical_name": "positive regulation of intermediate filament polymerization", "definition": "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization. [GOC:mah]"}
{"concept_id": "C1326267", "aliases": [], "types": ["T043"], "canonical_name": "anastral spindle assembly involved in male meiosis", "definition": "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells. [GOC:tb, PMID:11973272]"}
{"concept_id": "C1326270", "aliases": [], "types": ["T043"], "canonical_name": "sperm aster formation", "definition": "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1326271", "aliases": ["mitochondrial migration along microtubule", "mitochondrial transport along microtubule"], "types": ["T043"], "canonical_name": "mitochondrion transport along microtubule", "definition": "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins. [GOC:ecd]"}
{"concept_id": "C1326272", "aliases": ["microtubule-based vesicle localization"], "types": ["T043"], "canonical_name": "vesicle transport along microtubule", "definition": "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. [GOC:ecd, GOC:rl]"}
{"concept_id": "C1326273", "aliases": ["ovarian fusome organisation", "ovarian fusome organization and biogenesis"], "types": ["T043"], "canonical_name": "ovarian fusome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions. [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]"}
{"concept_id": "C1326274", "aliases": ["testicular fusome organization and biogenesis", "testicular fusome organisation"], "types": ["T043"], "canonical_name": "testicular fusome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome. [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]"}
{"concept_id": "C1326275", "aliases": ["regulation of transport across mitochondrial membrane"], "types": ["T043"], "canonical_name": "regulation of mitochondrial membrane permeability", "definition": "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. [GOC:bf]"}
{"concept_id": "C1326276", "aliases": [], "types": ["T043"], "canonical_name": "organelle fission", "definition": "The creation of two or more organelles by division of one organelle. [GOC:jid]"}
{"concept_id": "C1326277", "aliases": [], "types": ["T043"], "canonical_name": "organelle fusion", "definition": "The creation of a single organelle from two or more organelles. [GOC:jid]"}
{"concept_id": "C1326278", "aliases": [], "types": ["T043"], "canonical_name": "nuclear membrane fusion during karyogamy"}
{"concept_id": "C1326279", "aliases": ["membrane raft formation", "lipid raft assembly", "lipid raft formation"], "types": ["T043"], "canonical_name": "membrane raft assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes. [PMID:12648772, PMID:12803918, PMID:16645198]"}
{"concept_id": "C1326280", "aliases": ["membrane polarization", "lipid raft polarization"], "types": ["T043"], "canonical_name": "membrane raft polarization", "definition": "The clustering and aggregation of a membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. [PMID:12615889]"}
{"concept_id": "C1326281", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane repair", "definition": "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. [GOC:add, PMID:12925704]"}
{"concept_id": "C1326282", "aliases": ["chloroplast division"], "types": ["T043"], "canonical_name": "chloroplast fission", "definition": "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis. [GOC:lr]"}
{"concept_id": "C1326283", "aliases": [], "types": ["T043"], "canonical_name": "chloroplast elongation", "definition": "Expansion of the chloroplast that usually precedes division. [GOC:lr]"}
{"concept_id": "C1326284", "aliases": ["glyoxysome organization and biogenesis", "glyoxysome organisation"], "types": ["T043"], "canonical_name": "glyoxysome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway. [GOC:tb]"}
{"concept_id": "C1326285", "aliases": ["thylakoid membrane organization and biogenesis", "thylakoid membrane organisation"], "types": ["T043"], "canonical_name": "thylakoid membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane. [GOC:dph, GOC:jl, GOC:mah, GOC:tb]"}
{"concept_id": "C1326286", "aliases": ["polar granule organization and biogenesis", "polar granule organisation"], "types": ["T043"], "canonical_name": "P granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes. [PMID:10851135, PMID:770367]"}
{"concept_id": "C1326288", "aliases": ["spectrosome organization and biogenesis", "spectrosome organisation"], "types": ["T043"], "canonical_name": "spectrosome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome. [PMID:11131529]"}
{"concept_id": "C1326289", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein", "definition": "The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan. [RESID:AA0345]"}
{"concept_id": "C1326290", "aliases": ["teichuronic acid synthesis", "teichuronic acid formation", "teichuronic acid biosynthesis", "teichuronic acid anabolism"], "types": ["T044"], "canonical_name": "teichuronic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria. [ISBN:0815108893]"}
{"concept_id": "C1326291", "aliases": [], "types": ["T043"], "canonical_name": "male pronuclear envelope synthesis", "definition": "Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation. [GOC:bf, PMID:11735001]"}
{"concept_id": "C1326292", "aliases": ["pore biosynthesis", "pore complex biogenesis", "pore formation"], "types": ["T043"], "canonical_name": "pore complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. [GOC:jl, GOC:mah]"}
{"concept_id": "C1326294", "aliases": [], "types": ["T045"], "canonical_name": "regulation of histone acetylation", "definition": "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein. [GOC:bf]"}
{"concept_id": "C1326295", "aliases": ["downregulation of histone acetylation", "down regulation of histone acetylation", "down-regulation of histone acetylation"], "types": ["T045"], "canonical_name": "negative regulation of histone acetylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. [GOC:bf]"}
{"concept_id": "C1326296", "aliases": ["up-regulation of histone acetylation", "upregulation of histone acetylation", "up regulation of histone acetylation"], "types": ["T045"], "canonical_name": "positive regulation of histone acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. [GOC:bf]"}
{"concept_id": "C1326300", "aliases": ["sperm chromatin decondensation"], "types": ["T043"], "canonical_name": "sperm DNA decondensation", "definition": "Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus. [GOC:bf, PMID:11735001]"}
{"concept_id": "C1326301", "aliases": ["sperm-specific histone exchange", "sperm-specific histone replacement"], "types": ["T043"], "canonical_name": "fertilization, exchange of chromosomal proteins", "definition": "Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity. [GOC:bf, PMID:11735001]"}
{"concept_id": "C1326302", "aliases": [], "types": ["T043"], "canonical_name": "oocyte karyosome formation", "definition": "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome. [PMID:11700288, PMID:18039935]"}
{"concept_id": "C1326303", "aliases": [], "types": ["T045"], "canonical_name": "polytene chromosome puffing", "definition": "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals. [GOC:bf, PMID:12543962]"}
{"concept_id": "C1326304", "aliases": [], "types": ["T043"], "canonical_name": "ecdysone-mediated polytene chromosome puffing", "definition": "The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation. [GOC:bf, PMID:12543962]"}
{"concept_id": "C1326305", "aliases": [], "types": ["T043"], "canonical_name": "heat shock-mediated polytene chromosome puffing", "definition": "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus. [GOC:bf, PMID:12543962]"}
{"concept_id": "C1326306", "aliases": ["ribosomal DNA maintenance", "rDNA maintenance"], "types": ["T045"], "canonical_name": "maintenance of rDNA", "definition": "Any process involved in sustaining the fidelity and copy number of rDNA repeats. [GOC:vw, PMID:14528010]"}
{"concept_id": "C1326307", "aliases": ["down regulation of telomeric recombination at telomere", "negative regulation of telomeric recombination at telomere", "downregulation of telomeric recombination at telomere", "suppression of telomeric recombination at telomere", "down-regulation of telomeric recombination at telomere"], "types": ["T043"], "canonical_name": "negative regulation of DNA recombination at telomere", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere. [GOC:jid, PMID:9635193]"}
{"concept_id": "C1326308", "aliases": [], "types": ["T043"], "canonical_name": "female pronucleus assembly", "definition": "Assembly of the haploid nucleus of the unfertilized egg. [GOC:bf, ISBN:0582227089]"}
{"concept_id": "C1326309", "aliases": ["nuclear speck organization and biogenesis", "nuclear speckle assembly", "nuclear speck organisation", "nuclear speckle organization"], "types": ["T043"], "canonical_name": "nuclear speck organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized. [GOC:bf, GOC:curators]"}
{"concept_id": "C1326314", "aliases": ["chromosome condensation involved in meiotic cell cycle"], "types": ["T043"], "canonical_name": "meiotic chromosome condensation", "definition": "Compaction of chromatin structure prior to meiosis in eukaryotic cells. [PMID:10072401]"}
{"concept_id": "C1326315", "aliases": ["negative regulation of DNA replication at replication fork barrier", "replication fork blocking", "replication fork stalling"], "types": ["T045"], "canonical_name": "replication fork arrest", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected. [GOC:jl, GOC:pr, PMID:14645529]"}
{"concept_id": "C1326316", "aliases": ["mtDNA replication", "replication of mitochondrial DNA"], "types": ["T045"], "canonical_name": "mitochondrial DNA replication", "definition": "The process in which new strands of DNA are synthesized in the mitochondrion. [GOC:ai]"}
{"concept_id": "C1326317", "aliases": [], "types": ["T045"], "canonical_name": "replication of extrachromosomal circular DNA", "definition": "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication. [GOC:jh, PMID:33867825]"}
{"concept_id": "C1326319", "aliases": ["down regulation of exit from mitosis", "downregulation of exit from mitosis", "down-regulation of exit from mitosis"], "types": ["T043"], "canonical_name": "negative regulation of exit from mitosis", "definition": "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). [GOC:rn]"}
{"concept_id": "C1326320", "aliases": [], "types": ["T043"], "canonical_name": "meiotic metaphase I plate congression", "definition": "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I. [GOC:cab1, PMID:10809666]"}
{"concept_id": "C1326321", "aliases": [], "types": ["T043"], "canonical_name": "meiotic metaphase II plate congression", "definition": "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II. [GOC:cab1, PMID:10809666]"}
{"concept_id": "C1326322", "aliases": ["positive regulation of cell cycle arrest by p53-mediated DNA damage response"], "types": ["T043"], "canonical_name": "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest", "definition": "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle. [GOC:go_curators]"}
{"concept_id": "C1326323", "aliases": ["germarium-derived cystoblast cell division"], "types": ["T043"], "canonical_name": "germarium-derived cystoblast division", "definition": "The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster. [GOC:jid, GOC:mtg_sensu, PMID:11131529]"}
{"concept_id": "C1326325", "aliases": ["female germ-line stem cell renewal"], "types": ["T043"], "canonical_name": "female germ-line stem cell asymmetric division", "definition": "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1326327", "aliases": ["male germ-line stem cell renewal"], "types": ["T043"], "canonical_name": "male germ-line stem cell asymmetric division", "definition": "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes. [GOC:jid]"}
{"concept_id": "C1326328", "aliases": [], "types": ["T043"], "canonical_name": "zygote asymmetric cytokinesis"}
{"concept_id": "C1326329", "aliases": [], "types": ["T043"], "canonical_name": "zygote asymmetric cytokinesis in embryo sac", "definition": "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana. [GOC:mtg_sensu, GOC:tb, ISBN:0865427429]"}
{"concept_id": "C1326330", "aliases": ["division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle", "division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle", "formation of division septum involved in mitotic cell cycle", "septation", "mitotic division septum assembly", "division septum formation", "formation of division septum", "division septum formation involved in cell cycle cytokinesis", "division septum formation involved in mitotic cell cycle", "division septum assembly"], "types": ["T043"], "definition": "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. [GOC:mtg_cell_cycle]", "canonical_name": "division septum assembly involved in cell cycle cytokinesis"}
{"concept_id": "C1326331", "aliases": ["selection of site for division septum formation", "selection of site for barrier cell septum formation", "septum positioning", "selection of site for barrier cell septum biosynthesis"], "types": ["T043"], "canonical_name": "division septum site selection", "definition": "The process of marking the site where a division septum will form. [GOC:clt]"}
{"concept_id": "C1326332", "aliases": ["prokaryotic fission", "prokaryote-type cytokinesis"], "types": ["T043"], "canonical_name": "cytokinesis by binary fission"}
{"concept_id": "C1326333", "aliases": [], "types": ["T043"], "canonical_name": "cytokinetic cell separation"}
{"concept_id": "C1326334", "aliases": [], "types": ["T043"], "canonical_name": "cell plate formation"}
{"concept_id": "C1326335", "aliases": ["phragmoplast formation"], "types": ["T043"], "canonical_name": "phragmoplast assembly", "definition": "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles). [GOC:clt]"}
{"concept_id": "C1326336", "aliases": [], "types": ["T043"], "canonical_name": "preprophase band formation"}
{"concept_id": "C1326337", "aliases": ["contractile ring contraction involved in cell cycle cytokinesis", "cytokinesis, contractile ring contraction", "actomyosin contractile ring constriction", "cytokinesis, actomyosin ring contraction"], "types": ["T043"], "canonical_name": "actomyosin contractile ring contraction", "definition": "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle. [GOC:clt, GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1326338", "aliases": ["formation of actomyosin apparatus involved in cytokinesis", "cytokinesis, formation of actomyosin apparatus", "actomyosin apparatus assembly involved in cytokinesis"], "types": ["T043"], "canonical_name": "assembly of actomyosin apparatus involved in cytokinesis", "definition": "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1326339", "aliases": [], "types": ["T043"], "canonical_name": "constriction ring assembly"}
{"concept_id": "C1326340", "aliases": [], "types": ["T043"], "canonical_name": "septin ring assembly", "definition": "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex. [GOC:clt]"}
{"concept_id": "C1326341", "aliases": [], "types": ["T043"], "definition": "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. [ISBN:0721662544]", "canonical_name": "epithelial cell proliferation"}
{"concept_id": "C1326342", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of epithelial cell proliferation. [GOC:ai]"}
{"concept_id": "C1326343", "aliases": ["downregulation of epithelial cell proliferation", "down regulation of epithelial cell proliferation", "down-regulation of epithelial cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of epithelial cell proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. [GOC:ai]"}
{"concept_id": "C1326344", "aliases": ["downregulation of urothelial cell proliferation", "down-regulation of urothelial cell proliferation", "down regulation of urothelial cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of urothelial cell proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation. [GOC:ai]"}
{"concept_id": "C1326345", "aliases": [], "types": ["T043"], "canonical_name": "regulation of urothelial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of urothelial cell proliferation. [GOC:ai]"}
{"concept_id": "C1326346", "aliases": [], "types": ["T043"], "canonical_name": "urothelial cell proliferation", "definition": "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria. [ISBN:0721662544]"}
{"concept_id": "C1326347", "aliases": [], "types": ["T043"], "canonical_name": "fibroblast proliferation", "definition": "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. [GOC:jid]"}
{"concept_id": "C1326348", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fibroblast proliferation", "definition": "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]"}
{"concept_id": "C1326349", "aliases": ["down regulation of fibroblast proliferation", "downregulation of fibroblast proliferation", "down-regulation of fibroblast proliferation"], "types": ["T043"], "canonical_name": "negative regulation of fibroblast proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]"}
{"concept_id": "C1326350", "aliases": ["up-regulation of fibroblast proliferation", "upregulation of fibroblast proliferation", "up regulation of fibroblast proliferation"], "types": ["T043"], "canonical_name": "positive regulation of fibroblast proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]"}
{"concept_id": "C1326351", "aliases": [], "types": ["T043"], "canonical_name": "inner cell mass cell proliferation", "definition": "The proliferation of cells in the inner cell mass. [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326352", "aliases": ["somatic stem cell renewal"], "types": ["T043"], "canonical_name": "somatic stem cell division", "definition": "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. [GOC:jid, ISBN:0582227089]"}
{"concept_id": "C1326353", "aliases": ["trophectoderm cell proliferation"], "types": ["T043"], "canonical_name": "trophectodermal cell proliferation", "definition": "The proliferation of cells in the trophectoderm. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326354", "aliases": ["plant spore formation"], "types": ["T043"], "canonical_name": "plant-type sporogenesis", "definition": "The formation of plant spores derived from the products of meiosis. The spore gives rise to gametophytes. [GOC:tb]"}
{"concept_id": "C1326355", "aliases": [], "types": ["T043"], "canonical_name": "amide transport", "definition": "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1326356", "aliases": ["amino acid uptake"], "types": ["T043"], "canonical_name": "amino acid import", "definition": "The directed movement of amino acids into a cell or organelle. [GOC:jl]"}
{"concept_id": "C1326359", "aliases": [], "types": ["T043"], "canonical_name": "D-amino acid transport", "definition": "The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C1326360", "aliases": [], "types": ["T043"], "canonical_name": "D-alanine transport", "definition": "The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C1326361", "aliases": [], "types": ["T043"], "canonical_name": "D-serine transport", "definition": "The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C1326362", "aliases": [], "types": ["T043"], "canonical_name": "L-cysteine transport"}
{"concept_id": "C1326363", "aliases": [], "types": ["T043"], "canonical_name": "beta-alanine transport", "definition": "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:hjd]"}
{"concept_id": "C1326364", "aliases": [], "types": ["T043"], "canonical_name": "homoserine transport", "definition": "The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1326365", "aliases": [], "types": ["T043"], "canonical_name": "arbutin transport", "definition": "The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, PMID:19965875]"}
{"concept_id": "C1326366", "aliases": [], "types": ["T043"], "canonical_name": "aldarate transport"}
{"concept_id": "C1326367", "aliases": [], "types": ["T043"], "canonical_name": "D-galactarate transport"}
{"concept_id": "C1326368", "aliases": [], "types": ["T043"], "canonical_name": "D-glucarate transport"}
{"concept_id": "C1326369", "aliases": [], "types": ["T043"], "canonical_name": "aldonate transport"}
{"concept_id": "C1326370", "aliases": [], "types": ["T043"], "canonical_name": "D-galactonate transport"}
{"concept_id": "C1326371", "aliases": [], "types": ["T043"], "canonical_name": "D-glucuronate transport"}
{"concept_id": "C1326372", "aliases": [], "types": ["T043"], "canonical_name": "glucoside transport", "definition": "The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1326373", "aliases": [], "types": ["T043"], "canonical_name": "salicin transport", "definition": "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1326374", "aliases": [], "types": ["T043"], "canonical_name": "arabinan transport"}
{"concept_id": "C1326375", "aliases": [], "types": ["T043"], "canonical_name": "L-arabinose transport"}
{"concept_id": "C1326376", "aliases": [], "types": ["T043"], "canonical_name": "D-ribose transport"}
{"concept_id": "C1326377", "aliases": [], "types": ["T043"], "canonical_name": "D-xylose transport"}
{"concept_id": "C1326378", "aliases": [], "types": ["T043"], "canonical_name": "dextrin transport", "definition": "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1326379", "aliases": [], "types": ["T043"], "canonical_name": "maltodextrin transport"}
{"concept_id": "C1326381", "aliases": [], "types": ["T043"], "canonical_name": "chloramphenicol transport"}
{"concept_id": "C1326382", "aliases": [], "types": ["T043"], "canonical_name": "fosmidomycin transport", "definition": "The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, PMID:12543685]"}
{"concept_id": "C1326383", "aliases": [], "types": ["T043"], "canonical_name": "microcin transport", "definition": "The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, PMID:11292337]"}
{"concept_id": "C1326384", "aliases": [], "types": ["T043"], "canonical_name": "microcin B17 transport", "definition": "The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, PMID:11292337]"}
{"concept_id": "C1326385", "aliases": [], "types": ["T043"], "canonical_name": "polymyxin transport", "definition": "The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1326386", "aliases": [], "types": ["T043"], "canonical_name": "transpiration", "definition": "Release of water by the plant into the air as water vapor mainly through leaves. [GOC:sm, ISBN:0879015322]"}
{"concept_id": "C1326387", "aliases": ["adrenaline transport"], "types": ["T043"], "canonical_name": "epinephrine transport", "definition": "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jid]"}
{"concept_id": "C1326388", "aliases": ["plasma membrane ATP synthesis coupled proton transport"], "types": ["T044"], "canonical_name": "proton motive force-driven plasma membrane ATP synthesis", "definition": "The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. [GOC:mtg_sensu, ISBN:0716731363]"}
{"concept_id": "C1326389", "aliases": ["mitochondrial ATP synthesis coupled proton transport"], "types": ["T044"], "canonical_name": "proton motive force-driven mitochondrial ATP synthesis", "definition": "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. [GOC:mtg_sensu, ISBN:0716731363]"}
{"concept_id": "C1326390", "aliases": [], "types": ["T044"], "canonical_name": "regulation of proton transport", "definition": "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:sm]"}
{"concept_id": "C1326391", "aliases": [], "types": ["T043"], "canonical_name": "cytoskeleton-dependent intracellular transport", "definition": "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. [GOC:mah]"}
{"concept_id": "C1326392", "aliases": ["cytosol to ER transport"], "types": ["T043"], "canonical_name": "cytosol to endoplasmic reticulum transport", "definition": "The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell. [GOC:ai]"}
{"concept_id": "C1326393", "aliases": ["Golgi-derived vesicle transport"], "types": ["T043"], "canonical_name": "Golgi vesicle transport", "definition": "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326395", "aliases": ["COPI coating of Golgi-derived vesicle"], "types": ["T043"], "canonical_name": "COPI coating of Golgi vesicle", "definition": "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326396", "aliases": ["Golgi-derived vesicle budding"], "types": ["T043"], "canonical_name": "Golgi vesicle budding", "definition": "The evagination of the Golgi membrane, resulting in formation of a vesicle. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326397", "aliases": ["formation of Golgi membrane priming complex"], "types": ["T043"], "canonical_name": "Golgi membrane priming complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326398", "aliases": ["dictyosome membrane bud coat oligomerisation", "Golgi membrane bud coat oligomerisation"], "types": ["T043"], "canonical_name": "dictyosome membrane binding by cytosolic coat proteins"}
{"concept_id": "C1326399", "aliases": ["Golgi-derived vesicle bud deformation and release"], "types": ["T043"], "canonical_name": "Golgi vesicle bud deformation and release", "definition": "The process in which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326400", "aliases": ["Golgi vesicle targeting"], "types": ["T043"], "canonical_name": "vesicle targeting, to, from or within Golgi", "definition": "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326401", "aliases": ["cis-Golgi to rough endoplasmic reticulum targeting", "vesicle targeting, cis-Golgi to rough ER", "cis-Golgi to rough ER targeting"], "types": ["T043"], "canonical_name": "vesicle targeting, cis-Golgi to rough endoplasmic reticulum", "definition": "The process in which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326402", "aliases": [], "types": ["T043"], "canonical_name": "Golgi transport vesicle coating", "definition": "The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326404", "aliases": ["inter-Golgi cisterna targeting"], "types": ["T043"], "canonical_name": "vesicle targeting, inter-Golgi cisterna", "definition": "The process in which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326405", "aliases": ["regulation of Golgi vesicle targeting"], "types": ["T043"], "canonical_name": "regulation of vesicle targeting, to, from or within Golgi", "definition": "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326406", "aliases": ["rough ER to cis-Golgi targeting", "rough endoplasmic reticulum to cis-Golgi targeting", "vesicle targeting, rough endoplasmic reticulum to cis-Golgi"], "types": ["T043"], "canonical_name": "vesicle targeting, rough ER to cis-Golgi", "definition": "The process in which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326407", "aliases": ["trans-Golgi to endosome targeting"], "types": ["T043"], "canonical_name": "vesicle targeting, trans-Golgi to endosome", "definition": "The process in which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326408", "aliases": ["Golgi-derived vesicle fusion to target membrane"], "types": ["T043"], "canonical_name": "Golgi vesicle fusion to target membrane", "definition": "The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326409", "aliases": ["Golgi vesicle coat protein depolymerization", "Golgi vesicle coat depolymerization", "Golgi-derived vesicle uncoating"], "types": ["T043"], "canonical_name": "Golgi vesicle uncoating", "definition": "The process in which Golgi vesicle coat proteins are depolymerized, and released for reuse. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326410", "aliases": ["Golgi vesicle to membrane docking", "Golgi-derived vesicle docking", "Golgi vesicle docking with target membrane"], "types": ["T043"], "canonical_name": "Golgi vesicle docking", "definition": "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326411", "aliases": ["Golgi-derived vesicle prefusion complex stabilization", "Golgi vesicle prefusion complex assembly"], "types": ["T043"], "canonical_name": "Golgi vesicle prefusion complex stabilization", "definition": "The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326412", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Golgi vesicle fusion to target membrane", "definition": "Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326413", "aliases": ["down-regulation of Golgi vesicle fusion to target membrane", "down regulation of Golgi vesicle fusion to target membrane", "downregulation of Golgi vesicle fusion to target membrane"], "types": ["T043"], "canonical_name": "negative regulation of Golgi vesicle fusion to target membrane", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326414", "aliases": ["up regulation of Golgi vesicle fusion to target membrane", "upregulation of Golgi vesicle fusion to target membrane", "up-regulation of Golgi vesicle fusion to target membrane"], "types": ["T043"], "canonical_name": "positive regulation of Golgi vesicle fusion to target membrane", "definition": "Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane. [GOC:jid, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326415", "aliases": ["inter-Golgi cisterna transport"], "types": ["T043"], "canonical_name": "inter-Golgi cisterna vesicle-mediated transport", "definition": "The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326416", "aliases": [], "types": ["T043"], "canonical_name": "Golgi to plasma membrane protein transport", "definition": "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. [ISBN:0716731363]"}
{"concept_id": "C1326417", "aliases": ["Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport"], "types": ["T043"], "canonical_name": "Golgi to plasma membrane CFTR protein transport", "definition": "The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. [GOC:jl]"}
{"concept_id": "C1326418", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Golgi to plasma membrane CFTR protein transport", "definition": "Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. [GOC:jl]"}
{"concept_id": "C1326419", "aliases": ["down regulation of Golgi to plasma membrane CFTR protein transport", "downregulation of Golgi to plasma membrane CFTR protein transport", "down-regulation of Golgi to plasma membrane CFTR protein transport"], "types": ["T043"], "canonical_name": "negative regulation of Golgi to plasma membrane CFTR protein transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. [GOC:jl]"}
{"concept_id": "C1326420", "aliases": ["cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein", "maintenance of CFTR protein location in cytoplasm", "sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm", "cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)", "storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm", "retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm", "sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm", "cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein", "cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein"], "types": ["T043"], "canonical_name": "cytoplasmic sequestering of CFTR protein", "definition": "The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane. [GOC:jl]"}
{"concept_id": "C1326421", "aliases": ["upregulation of Golgi to plasma membrane CFTR protein transport", "up-regulation of Golgi to plasma membrane CFTR protein transport", "up regulation of Golgi to plasma membrane CFTR protein transport"], "types": ["T043"], "canonical_name": "positive regulation of Golgi to plasma membrane CFTR protein transport", "definition": "Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. [GOC:jl]"}
{"concept_id": "C1326422", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Golgi to plasma membrane protein transport", "definition": "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. [GOC:jl]"}
{"concept_id": "C1326423", "aliases": ["down-regulation of Golgi to plasma membrane protein transport", "down regulation of Golgi to plasma membrane protein transport", "downregulation of Golgi to plasma membrane protein transport"], "types": ["T043"], "canonical_name": "negative regulation of Golgi to plasma membrane protein transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. [GOC:jl]"}
{"concept_id": "C1326424", "aliases": ["up regulation of Golgi to plasma membrane protein transport", "up-regulation of Golgi to plasma membrane protein transport", "upregulation of Golgi to plasma membrane protein transport"], "types": ["T043"], "canonical_name": "positive regulation of Golgi to plasma membrane protein transport", "definition": "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. [GOC:jl]"}
{"concept_id": "C1326428", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane to endosome transport", "definition": "Transport of a vesicle from the plasma membrane to the endosome. [GOC:jid]"}
{"concept_id": "C1326429", "aliases": ["regulation of protein transport from nucleus to cytoplasm", "regulation of protein-nucleus export", "regulation of protein export from cell nucleus", "regulation of protein export out of nucleus"], "types": ["T043"], "canonical_name": "regulation of protein export from nucleus", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. [GOC:bf]"}
{"concept_id": "C1326430", "aliases": ["down regulation of protein export from nucleus", "downregulation of protein export from nucleus", "negative regulation of protein transport from nucleus to cytoplasm", "negative regulation of protein-nucleus export", "negative regulation of protein export from cell nucleus", "down-regulation of protein export from nucleus", "negative regulation of protein export out of nucleus"], "types": ["T043"], "canonical_name": "negative regulation of protein export from nucleus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm. [GOC:bf]"}
{"concept_id": "C1326431", "aliases": ["positive regulation of protein-nucleus export", "positive regulation of protein export from cell nucleus", "upregulation of protein export from nucleus", "up-regulation of protein export from nucleus", "positive regulation of protein transport from nucleus to cytoplasm", "up regulation of protein export from nucleus", "positive regulation of protein export out of nucleus"], "types": ["T043"], "canonical_name": "positive regulation of protein export from nucleus", "definition": "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. [GOC:bf]"}
{"concept_id": "C1326435", "aliases": ["sequestering of transcription factor in cytoplasm", "cytoplasmic sequestration of transcription factor", "cytoplasmic retention of transcription factor", "storage of transcription factor in cytoplasm", "sequestration of transcription factor in cytoplasm", "cytoplasmic storage of transcription factor", "transcription factor binding, cytoplasmic sequestering", "maintenance of transcription factor protein location in cytoplasm", "retention of transcription factor in cytoplasm"], "types": ["T043"], "canonical_name": "cytoplasmic sequestering of transcription factor", "definition": "The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. [GOC:jl]"}
{"concept_id": "C1326439", "aliases": ["mitochondrial iron transport", "mitochondrial iron cation transmembrane transport", "mitochondrial iron ion transport"], "types": ["T043"], "canonical_name": "iron import into the mitochondrion", "definition": "The process in which iron is transported from the cytosol into the mitochondrial matrix. [GOC:jid, PMID:12006577]"}
{"concept_id": "C1326440", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nucleocytoplasmic transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. [GOC:bf]"}
{"concept_id": "C1326441", "aliases": ["downregulation of nucleocytoplasmic transport", "down-regulation of nucleocytoplasmic transport", "down regulation of nucleocytoplasmic transport"], "types": ["T043"], "canonical_name": "negative regulation of nucleocytoplasmic transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. [GOC:bf]"}
{"concept_id": "C1326442", "aliases": ["down regulation of RNA export from nucleus", "negative regulation of RNA export out of nucleus", "negative regulation of RNA transport from nucleus to cytoplasm", "negative regulation of RNA export from cell nucleus", "negative regulation of RNA-nucleus export", "downregulation of RNA export from nucleus", "down-regulation of RNA export from nucleus"], "types": ["T043"], "canonical_name": "negative regulation of RNA export from nucleus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm. [GOC:bf]"}
{"concept_id": "C1326443", "aliases": ["down regulation of RNA import into nucleus", "negative regulation of RNA-nucleus import", "negative regulation of RNA transport from cytoplasm to nucleus", "downregulation of RNA import into nucleus", "negative regulation of RNA import into cell nucleus", "down-regulation of RNA import into nucleus"], "types": ["T043"], "canonical_name": "negative regulation of RNA import into nucleus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus. [GOC:bf]"}
{"concept_id": "C1326444", "aliases": ["up-regulation of nucleocytoplasmic transport", "upregulation of nucleocytoplasmic transport", "up regulation of nucleocytoplasmic transport"], "types": ["T043"], "canonical_name": "positive regulation of nucleocytoplasmic transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. [GOC:bf]"}
{"concept_id": "C1326445", "aliases": ["positive regulation of RNA export out of nucleus", "up-regulation of RNA export from nucleus", "upregulation of RNA export from nucleus", "up regulation of RNA export from nucleus", "positive regulation of RNA transport from nucleus to cytoplasm", "positive regulation of RNA export from cell nucleus", "positive regulation of RNA-nucleus export"], "types": ["T043"], "canonical_name": "positive regulation of RNA export from nucleus", "definition": "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm. [GOC:bf]"}
{"concept_id": "C1326446", "aliases": ["up regulation of RNA import into nucleus", "positive regulation of RNA transport from cytoplasm to nucleus", "upregulation of RNA import into nucleus", "up-regulation of RNA import into nucleus", "positive regulation of RNA import into cell nucleus", "positive regulation of RNA-nucleus import"], "types": ["T043"], "canonical_name": "positive regulation of RNA import into nucleus", "definition": "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus. [GOC:bf]"}
{"concept_id": "C1326447", "aliases": ["regulation of RNA export out of nucleus", "regulation of RNA transport from nucleus to cytoplasm", "regulation of RNA-nucleus export", "regulation of RNA export from cell nucleus"], "types": ["T043"], "canonical_name": "regulation of RNA export from nucleus", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm. [GOC:bf]"}
{"concept_id": "C1326448", "aliases": ["regulation of RNA import into cell nucleus", "regulation of RNA transport from cytoplasm to nucleus", "regulation of RNA-nucleus import"], "types": ["T043"], "canonical_name": "regulation of RNA import into nucleus", "definition": "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus. [GOC:bf]"}
{"concept_id": "C1326449", "aliases": ["3-phenylpropionate transport", "HCA transport", "hydrocinnamic acid transport"], "types": ["T043"], "canonical_name": "3-phenylpropionic acid transport", "definition": "The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1326452", "aliases": ["potassium import", "potassium ion uptake"], "types": ["T043"], "canonical_name": "potassium ion import"}
{"concept_id": "C1326453", "aliases": [], "types": ["T043"], "canonical_name": "isoprenoid transport", "definition": "The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [GOC:ai]"}
{"concept_id": "C1326454", "aliases": [], "types": ["T043"], "canonical_name": "terpenoid transport", "definition": "The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups. [GOC:ai]"}
{"concept_id": "C1326455", "aliases": [], "types": ["T043"], "canonical_name": "tetraterpenoid transport", "definition": "The directed movement of tetraterpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units. [GOC:ai]"}
{"concept_id": "C1326456", "aliases": [], "types": ["T043"], "canonical_name": "carotenoid transport", "definition": "The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. [GOC:ai]"}
{"concept_id": "C1326458", "aliases": [], "types": ["T043"], "canonical_name": "glycolipid transport", "definition": "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1326459", "aliases": [], "types": ["T043"], "canonical_name": "nucleic acid transport", "definition": "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1326460", "aliases": [], "types": ["T043"], "canonical_name": "cytokinin transport", "definition": "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:lr]"}
{"concept_id": "C1326461", "aliases": ["xanthine transmembrane transport"], "types": ["T043"], "canonical_name": "xanthine transport", "definition": "The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. [GOC:jl]"}
{"concept_id": "C1326462", "aliases": ["PAPS transport", "adenosine 3'-phosphate 5'-phosphosulfate transport", "3'-phosphoadenosine 5'-phosphosulphate transport"], "types": ["T043"], "canonical_name": "3'-phosphoadenosine 5'-phosphosulfate transport", "definition": "The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732]"}
{"concept_id": "C1326463", "aliases": [], "types": ["T043"], "canonical_name": "organic acid transport", "definition": "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732]"}
{"concept_id": "C1326464", "aliases": [], "types": ["T043"], "canonical_name": "carboxylic acid transport", "definition": "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). [GOC:ai]"}
{"concept_id": "C1326465", "aliases": [], "types": ["T043"], "canonical_name": "dipeptide transport", "definition": "The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1326466", "aliases": [], "types": ["T043"], "canonical_name": "peptide antigen transport", "definition": "The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1326467", "aliases": [], "types": ["T043"], "canonical_name": "tripeptide transport", "definition": "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1326468", "aliases": [], "types": ["T043"], "canonical_name": "colicin transport", "definition": "The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1. [GOC:jl, PMID:17347522]"}
{"concept_id": "C1326469", "aliases": [], "types": ["T043"], "canonical_name": "group A colicin transport", "definition": "The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, PMID:9171417]"}
{"concept_id": "C1326470", "aliases": [], "types": ["T043"], "canonical_name": "lipoprotein transport", "definition": "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1326471", "aliases": ["protein uptake"], "types": ["T043"], "definition": "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. [GOC:ai]", "canonical_name": "protein import"}
{"concept_id": "C1326473", "aliases": [], "types": ["T043"], "canonical_name": "vesicle docking during exocytosis"}
{"concept_id": "C1326474", "aliases": [], "types": ["T043"], "canonical_name": "vesicle fusion", "definition": "Fusion of the membrane of a transport vesicle with its target membrane. [GOC:jid]"}
{"concept_id": "C1326475", "aliases": [], "types": ["T043"], "canonical_name": "vesicle targeting", "definition": "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. [GOC:mah, PMID:17335816]"}
{"concept_id": "C1326476", "aliases": ["plasma membrane to endosome targeting"], "types": ["T043"], "canonical_name": "vesicle targeting, plasma membrane to endosome", "definition": "The process in which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1326477", "aliases": [], "types": ["T043"], "canonical_name": "achromobactin transport", "definition": "The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, PMID:10928541]"}
{"concept_id": "C1326478", "aliases": [], "types": ["T043"], "canonical_name": "chrysobactin transport", "definition": "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, PMID:8837459]"}
{"concept_id": "C1326479", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phagocytosis", "definition": "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. [GOC:ai]"}
{"concept_id": "C1326480", "aliases": ["down regulation of phagocytosis", "downregulation of phagocytosis", "down-regulation of phagocytosis"], "types": ["T043"], "canonical_name": "negative regulation of phagocytosis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. [GOC:ai]"}
{"concept_id": "C1326481", "aliases": ["upregulation of phagocytosis", "up-regulation of phagocytosis", "up regulation of phagocytosis"], "types": ["T043"], "canonical_name": "positive regulation of phagocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of phagocytosis. [GOC:ai]"}
{"concept_id": "C1326482", "aliases": ["regulation of receptor mediated endocytosis"], "types": ["T043"], "canonical_name": "regulation of receptor-mediated endocytosis", "definition": "Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1326483", "aliases": ["downregulation of receptor mediated endocytosis", "negative regulation of receptor mediated endocytosis", "down regulation of receptor mediated endocytosis", "down-regulation of receptor mediated endocytosis"], "types": ["T043"], "canonical_name": "negative regulation of receptor-mediated endocytosis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. [GOC:go_curators]"}
{"concept_id": "C1326484", "aliases": ["up regulation of receptor mediated endocytosis", "up-regulation of receptor mediated endocytosis", "positive regulation of receptor mediated endocytosis", "upregulation of receptor mediated endocytosis"], "types": ["T043"], "canonical_name": "positive regulation of receptor-mediated endocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1326485", "aliases": ["vesicle budding"], "types": ["T043"], "canonical_name": "nonselective vesicle assembly"}
{"concept_id": "C1326486", "aliases": [], "types": ["T043"], "canonical_name": "vesicle coat assembly"}
{"concept_id": "C1326487", "aliases": ["enterochelin transport"], "types": ["T043"], "canonical_name": "enterobactin transport", "definition": "The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1326488", "aliases": [], "types": ["T043"], "canonical_name": "ferrichrome transport"}
{"concept_id": "C1326489", "aliases": ["vesicle to membrane docking"], "types": ["T043"], "canonical_name": "vesicle docking", "definition": "The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. [GOC:ai, GOC:jid]"}
{"concept_id": "C1326491", "aliases": ["vesicle fusion with ER"], "types": ["T043"], "canonical_name": "vesicle fusion with endoplasmic reticulum", "definition": "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum. [GOC:jid]"}
{"concept_id": "C1326492", "aliases": [], "types": ["T043"], "canonical_name": "vesicle fusion with Golgi apparatus", "definition": "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. [GOC:jid]"}
{"concept_id": "C1326493", "aliases": [], "types": ["T043"], "canonical_name": "xenobiotic transport", "definition": "The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]"}
{"concept_id": "C1326494", "aliases": ["m-hydroxyphenylpropionic acid transport", "3-(3-hydroxyphenyl)propionic acid transport", "3-hydroxyphenylpropionic acid transport"], "types": ["T043"], "canonical_name": "3-hydroxyphenylpropionic acid transmembrane transport", "definition": "The directed movement of 3-hydroxyphenylpropionic acid across a lipid bilayer, from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C1326495", "aliases": [], "types": ["T043"], "canonical_name": "acridine transport", "definition": "The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, Wikipedia:Acridine]"}
{"concept_id": "C1326496", "aliases": ["alkanesulphonate transport"], "types": ["T043"], "canonical_name": "alkanesulfonate transport", "definition": "The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical. [GOC:jl]"}
{"concept_id": "C1326497", "aliases": [], "types": ["T043"], "canonical_name": "benzoate transport", "definition": "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, ISBN:0721662544]"}
{"concept_id": "C1326498", "aliases": [], "types": ["T043"], "canonical_name": "dorsal closure, spreading of leading edge cells", "definition": "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa. [GOC:bf, PMID:12147138]"}
{"concept_id": "C1326500", "aliases": ["immune cell migration", "leukocyte migration", "leucocyte migration", "leukocyte trafficking", "leucocyte trafficking"], "types": ["T043"], "definition": "The movement of a leukocyte within or between different tissues and organs of the body. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]", "canonical_name": "immune cell trafficking"}
{"concept_id": "C1326501", "aliases": [], "types": ["T043"], "canonical_name": "eosinophil chemotaxis", "definition": "The movement of an eosinophil in response to an external stimulus. [GOC:jid, PMID:11292027, PMID:12391252]"}
{"concept_id": "C1326502", "aliases": [], "types": ["T043"], "canonical_name": "macrophage chemotaxis", "definition": "The movement of a macrophage in response to an external stimulus. [GOC:jid]"}
{"concept_id": "C1326503", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell migration", "definition": "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]"}
{"concept_id": "C1326504", "aliases": ["neuron chemotaxis", "neuronal migration"], "types": ["T043"], "definition": "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. [CL:0000540, GOC:go_curators]", "canonical_name": "neuron migration"}
{"concept_id": "C1326505", "aliases": ["TFP-dependent movement", "TFP-dependent motility", "type four pilus-dependent motility", "type 4 pilus-dependent motility"], "types": ["T043"], "canonical_name": "type IV pilus-dependent motility", "definition": "Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility. [GOC:go_curators, PMID:12704238]"}
{"concept_id": "C1326507", "aliases": [], "types": ["T046"], "canonical_name": "regulation of type IV hypersensitivity", "definition": "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1326508", "aliases": ["downregulation of type IV hypersensitivity", "down regulation of type IV hypersensitivity", "down-regulation of type IV hypersensitivity"], "types": ["T040"], "canonical_name": "negative regulation of type IV hypersensitivity", "definition": "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1326509", "aliases": ["up regulation of type IV hypersensitivity", "up-regulation of type IV hypersensitivity", "upregulation of type IV hypersensitivity"], "types": ["T040"], "canonical_name": "positive regulation of type IV hypersensitivity", "definition": "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1326510", "aliases": ["regulation of cellular defence response"], "types": ["T043"], "canonical_name": "regulation of cellular defense response", "definition": "Any process that modulates the frequency, rate or extent of cellular defense response. [GOC:sm]"}
{"concept_id": "C1326511", "aliases": ["upregulation of cellular defense response", "up regulation of cellular defense response", "up-regulation of cellular defense response", "positive regulation of cellular defence response"], "types": ["T043"], "canonical_name": "positive regulation of cellular defense response", "definition": "Any process that activates or increases the frequency, rate or extent of cellular defense response. [GOC:sm]"}
{"concept_id": "C1326513", "aliases": ["elastin fiber assembly", "elastic fibre assembly", "elastin fibre assembly"], "types": ["T043"], "canonical_name": "elastic fiber assembly", "definition": "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. [GOC:jid, PMID:10841810, PMID:12615674]"}
{"concept_id": "C1326514", "aliases": ["synapse development", "synapse organization and biogenesis", "synapse organisation"], "types": ["T043"], "canonical_name": "synapse organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai, GOC:pr]"}
{"concept_id": "C1326515", "aliases": [], "types": ["T042"], "canonical_name": "regulation of long-term neuronal synaptic plasticity", "definition": "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. [GOC:jid, PMID:11891290]"}
{"concept_id": "C1326516", "aliases": ["down-regulation of long-term neuronal synaptic plasticity", "downregulation of long-term neuronal synaptic plasticity", "down regulation of long-term neuronal synaptic plasticity"], "types": ["T042"], "canonical_name": "negative regulation of long-term neuronal synaptic plasticity", "definition": "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. [GOC:jid, PMID:11891290]"}
{"concept_id": "C1326517", "aliases": ["up regulation of long-term neuronal synaptic plasticity", "up-regulation of long-term neuronal synaptic plasticity", "upregulation of long-term neuronal synaptic plasticity"], "types": ["T042"], "canonical_name": "positive regulation of long-term neuronal synaptic plasticity", "definition": "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. [GOC:jid, PMID:11891290]"}
{"concept_id": "C1326518", "aliases": [], "types": ["T044"], "canonical_name": "regulation of photosynthesis, dark reaction", "definition": "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction. [GOC:sm]"}
{"concept_id": "C1326519", "aliases": [], "types": ["T044"], "canonical_name": "photosystem II repair", "definition": "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition. [GOC:sm]"}
{"concept_id": "C1326520", "aliases": [], "types": ["T044"], "canonical_name": "photoinhibition", "definition": "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II. [GOC:mtg_electron_transport, PMID:12068126]"}
{"concept_id": "C1326521", "aliases": [], "types": ["T044"], "canonical_name": "photosystem II assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on the thylakoid membrane. The photosystem II complex consists of at least 20 polypeptides and around 80 cofactors in most organisms. [GOC:aa, GOC:pz]"}
{"concept_id": "C1326522", "aliases": [], "types": ["T039"], "canonical_name": "regulation of photosynthesis", "definition": "Any process that modulates the frequency, rate or extent of photosynthesis. [GOC:sm]"}
{"concept_id": "C1326523", "aliases": [], "types": ["T043"], "canonical_name": "pilus retraction", "definition": "The process of withdrawing a pilus back into a cell. [GOC:go_curators, PMID:17355871]"}
{"concept_id": "C1326524", "aliases": [], "types": ["T039"], "canonical_name": "stomatal movement", "definition": "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata). [GOC:sm]"}
{"concept_id": "C1326525", "aliases": [], "types": ["T039"], "canonical_name": "regulation of stomatal movement", "definition": "Any process that modulates the frequency, rate or extent of stomatal movement. [GOC:sm]"}
{"concept_id": "C1326526", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fusion of sperm to egg plasma membrane", "definition": "Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane. [GOC:jl, PMID:11483596]"}
{"concept_id": "C1326527", "aliases": ["inhibition of sperm-oocyte fusion"], "types": ["T043"], "canonical_name": "negative regulation of sperm-oocyte fusion"}
{"concept_id": "C1326528", "aliases": ["regulation of cellular physiological process"], "types": ["T043"], "canonical_name": "regulation of cellular process", "definition": "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators]"}
{"concept_id": "C1326530", "aliases": [], "types": ["T040"], "definition": "The last stage of leaf development during which programmed degradation of macromolecules and nutrient recycling take place. [ISBN:0387987819, PMID:17177638, PMID:34938309]", "canonical_name": "leaf senescence"}
{"concept_id": "C1326531", "aliases": [], "types": ["T039"], "canonical_name": "blastocyst development", "definition": "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326532", "aliases": [], "types": ["T039"], "canonical_name": "blastocyst formation", "definition": "The initial formation of a blastocyst from a solid ball of cells known as a morula. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326533", "aliases": [], "types": ["T040"], "canonical_name": "blastocyst growth", "definition": "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326534", "aliases": [], "types": ["T039"], "canonical_name": "blastocyst hatching", "definition": "The hatching of the cellular blastocyst from the zona pellucida. [GOC:dph, ISBN:0124020607, ISBN:0198542771]"}
{"concept_id": "C1326535", "aliases": [], "types": ["T045"], "canonical_name": "DNA methylation involved in embryo development", "definition": "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression. [GOC:go_curators, PMID:12138111]"}
{"concept_id": "C1326536", "aliases": [], "types": ["T040"], "canonical_name": "chordate embryonic development", "definition": "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. [GOC:mtg_sensu]"}
{"concept_id": "C1326538", "aliases": ["optic placode formation in camera-type eye", "optic placode formation involved in camera-type eye formation", "optic placode formation involved in camera-style eye"], "types": ["T040"], "canonical_name": "lens placode formation involved in camera-type eye formation", "definition": "Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles. [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C1326539", "aliases": ["formation of mesodermal clusters"], "types": ["T040"], "canonical_name": "somitogenesis", "definition": "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. [ISBN:0721662544]"}
{"concept_id": "C1326540", "aliases": [], "types": ["T040"], "canonical_name": "somite specification", "definition": "The process in which individual somites establish identity during embryogenesis. [GOC:dph]"}
{"concept_id": "C1326541", "aliases": ["deuterostomic gastrulation"], "types": ["T040"], "canonical_name": "gastrulation with mouth forming second", "definition": "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1326544", "aliases": [], "types": ["T040"], "canonical_name": "gastrulation involving germ band extension", "definition": "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1326545", "aliases": [], "types": ["T040"], "canonical_name": "embryonic root morphogenesis", "definition": "The process in which the anatomical structures of the embryonic root are generated and organized. [GOC:tb]"}
{"concept_id": "C1326546", "aliases": ["primary shoot system morphogenesis"], "types": ["T040"], "canonical_name": "embryonic shoot morphogenesis", "definition": "The process in which the anatomical structures of embryonic shoot are generated and organized. [GOC:tb]"}
{"concept_id": "C1326547", "aliases": ["embryo shoot apical meristem specification"], "types": ["T040"], "canonical_name": "primary shoot apical meristem specification", "definition": "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers. [GOC:ascb_2009, GOC:dph, GOC:tair_curators, GOC:tb]"}
{"concept_id": "C1326548", "aliases": [], "types": ["T040"], "canonical_name": "root meristem specification", "definition": "The specification of a meristem which will give rise to a primary or lateral root. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C1326549", "aliases": ["primary meristem histogenesis"], "types": ["T040"], "canonical_name": "primary meristem tissue development", "definition": "The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium. [GOC:tb, ISBN:0471245208]"}
{"concept_id": "C1326550", "aliases": [], "types": ["T040"], "canonical_name": "ground meristem histogenesis", "definition": "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues. [GOC:tb, ISBN:0471245208]"}
{"concept_id": "C1326551", "aliases": [], "types": ["T040"], "canonical_name": "procambium histogenesis", "definition": "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue. [GOC:tb, ISBN:0471245208]"}
{"concept_id": "C1326552", "aliases": [], "types": ["T040"], "canonical_name": "protoderm histogenesis", "definition": "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis. [GOC:tb, ISBN:0471245208]"}
{"concept_id": "C1326553", "aliases": [], "types": ["T040"], "canonical_name": "seed dormancy"}
{"concept_id": "C1326554", "aliases": [], "types": ["T042"], "canonical_name": "antennal joint development", "definition": "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments. [GOC:jid]"}
{"concept_id": "C1326555", "aliases": [], "types": ["T042"], "canonical_name": "elongation of arista core", "definition": "The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions. [GOC:bf, PMID:11404081]"}
{"concept_id": "C1326556", "aliases": [], "types": ["T042"], "canonical_name": "elongation of arista lateral", "definition": "The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions. [GOC:bf, PMID:11404081]"}
{"concept_id": "C1326557", "aliases": [], "types": ["T042"], "canonical_name": "otic placode formation", "definition": "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain. [GOC:go_curators, PMID:12668634]"}
{"concept_id": "C1326558", "aliases": [], "types": ["T040"], "canonical_name": "embryonic body morphogenesis", "definition": "The process in which the anatomical structures of the embryonic soma are generated and organized. [GOC:ems]"}
{"concept_id": "C1326559", "aliases": ["embryonic eye morphogenesis"], "types": ["T042"], "canonical_name": "embryonic eye morphogenesis", "definition": "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. [GOC:jid]"}
{"concept_id": "C1326561", "aliases": ["optic lobe and Bolwig's organ precursor formation", "optic lobe placode formation"], "types": ["T042"], "canonical_name": "insect visual primordium formation", "definition": "Establishment of the optic lobe placode. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system. [GOC:mtg_sensu, PMID:8402833]"}
{"concept_id": "C1326563", "aliases": [], "types": ["T040"], "canonical_name": "notochord development", "definition": "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. [GOC:dgh]"}
{"concept_id": "C1326564", "aliases": [], "types": ["T042"], "canonical_name": "optic placode formation"}
{"concept_id": "C1326565", "aliases": ["down-regulation of growth rate", "downregulation of growth rate", "down regulation of growth rate"], "types": ["T040"], "canonical_name": "negative regulation of growth rate", "definition": "Any process that reduces the rate of growth of all or part of an organism. [GOC:mah]"}
{"concept_id": "C1326566", "aliases": ["up regulation of growth rate", "up-regulation of growth rate", "upregulation of growth rate"], "types": ["T040"], "canonical_name": "positive regulation of growth rate", "definition": "Any process that increases the rate of growth of all or part of an organism. [GOC:mah]"}
{"concept_id": "C1326567", "aliases": [], "types": ["T040"], "canonical_name": "regulation of growth rate", "definition": "Any process that modulates the rate of growth of all or part of an organism. [GOC:mah]"}
{"concept_id": "C1326572", "aliases": ["regulation of cuticle tanning"], "types": ["T038"], "canonical_name": "regulation of chitin-based cuticle tanning", "definition": "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning. [GOC:go_curators, GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1326573", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of cuticle hardening"}
{"concept_id": "C1326574", "aliases": ["upregulation of cuticle tanning", "up-regulation of cuticle tanning", "positive regulation of cuticle tanning", "up regulation of cuticle tanning"], "types": ["T038"], "canonical_name": "positive regulation of chitin-based cuticle tanning", "definition": "Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning. [GOC:go_curators, GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1326575", "aliases": ["larval midgut regression"], "types": ["T042"], "canonical_name": "larval midgut histolysis", "definition": "The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly. [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683]"}
{"concept_id": "C1326576", "aliases": ["salivary gland regression"], "types": ["T042"], "canonical_name": "salivary gland histolysis", "definition": "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly. [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683]"}
{"concept_id": "C1326577", "aliases": ["puparium biosynthesis", "puparium formation"], "types": ["T040"], "canonical_name": "pupariation", "definition": "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis. [GOC:bf, ISBN:0879694238, PMID:9409683]"}
{"concept_id": "C1326578", "aliases": ["prepupal-pupal transition", "head eversion"], "types": ["T040"], "canonical_name": "pupation", "definition": "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period. [GOC:bf, ISBN:0582227089, ISBN:0879694238]"}
{"concept_id": "C1326579", "aliases": [], "types": ["T040"], "canonical_name": "response to ecdysone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus. [GOC:bf]"}
{"concept_id": "C1326580", "aliases": [], "types": ["T039"], "canonical_name": "meristem maintenance", "definition": "Any process involved in maintaining the identity, size and shape of a meristem. [GOC:tb]"}
{"concept_id": "C1326581", "aliases": ["meristem cell maintenance", "maintenance of meristem cell identity"], "types": ["T039"], "canonical_name": "maintenance of meristem identity", "definition": "The process in which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. [GOC:tb]"}
{"concept_id": "C1326582", "aliases": [], "types": ["T039"], "canonical_name": "maintenance of floral meristem identity", "definition": "The process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. [GOC:dph, GOC:tb]"}
{"concept_id": "C1326583", "aliases": [], "types": ["T039"], "canonical_name": "maintenance of inflorescence meristem identity", "definition": "The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. [GOC:dph, GOC:tb]"}
{"concept_id": "C1326584", "aliases": [], "types": ["T040"], "canonical_name": "maintenance of root meristem identity", "definition": "The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. [GOC:dph, GOC:tb]"}
{"concept_id": "C1326585", "aliases": [], "types": ["T039"], "canonical_name": "maintenance of vegetative meristem identity", "definition": "The process in which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. [GOC:dph, GOC:tb]"}
{"concept_id": "C1326586", "aliases": [], "types": ["T039"], "canonical_name": "meristem determinacy", "definition": "The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate). [GOC:lr]"}
{"concept_id": "C1326587", "aliases": ["regulation of meristem size"], "types": ["T039"], "canonical_name": "regulation of meristem growth", "definition": "Any process involved in maintaining the size and shape of a meristem. [GOC:tb]"}
{"concept_id": "C1326588", "aliases": ["regulation of floral meristem size"], "types": ["T039"], "canonical_name": "regulation of floral meristem growth", "definition": "Any process involved in maintaining the size and shape of a floral meristem. [GOC:tb]"}
{"concept_id": "C1326589", "aliases": ["regulation of inflorescence meristem size"], "types": ["T039"], "canonical_name": "regulation of inflorescence meristem growth", "definition": "Any process involved in maintaining the size and shape of an inflorescence meristem. [GOC:tb]"}
{"concept_id": "C1326590", "aliases": ["regulation of root meristem size"], "types": ["T040"], "canonical_name": "regulation of root meristem growth", "definition": "Any process involved in maintaining the size and shape of a root meristem. [GOC:tb]"}
{"concept_id": "C1326591", "aliases": ["regulation of vegetative meristem size"], "types": ["T039"], "canonical_name": "regulation of vegetative meristem growth", "definition": "Any process involved in maintaining the size and shape of a vegetative meristem. [GOC:tb]"}
{"concept_id": "C1326592", "aliases": [], "types": ["T042"], "canonical_name": "meristem initiation", "definition": "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue. [GOC:sm]"}
{"concept_id": "C1326593", "aliases": [], "types": ["T040"], "canonical_name": "body morphogenesis", "definition": "The process in which the anatomical structures of the soma are generated and organized. [GOC:ems, ISBN:0140512888]"}
{"concept_id": "C1326594", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic body morphogenesis", "definition": "The process in which the anatomical structures of the post-embryonic soma are generated and organized. [GOC:ems, ISBN:0140512888]"}
{"concept_id": "C1326596", "aliases": ["primary tracheal branching"], "types": ["T042"], "canonical_name": "primary branching, open tracheal system", "definition": "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:29844090]"}
{"concept_id": "C1326597", "aliases": ["secondary tracheal branching"], "types": ["T042"], "canonical_name": "secondary branching, open tracheal system", "definition": "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:29844090]"}
{"concept_id": "C1326598", "aliases": ["terminal branching of trachea, cytoplasmic projection extension"], "types": ["T042"], "canonical_name": "terminal branching, open tracheal system", "definition": "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:29844090]"}
{"concept_id": "C1326599", "aliases": [], "types": ["T040"], "canonical_name": "inflorescence morphogenesis", "definition": "The process in which the anatomical structures of inflorescences are generated and organized. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers. [GOC:jid]"}
{"concept_id": "C1326600", "aliases": [], "types": ["T040"], "canonical_name": "determinate inflorescence morphogenesis", "definition": "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can only produce a predetermined number of floral meristems. [GOC:jid, PMID:9553044]"}
{"concept_id": "C1326601", "aliases": [], "types": ["T040"], "canonical_name": "indeterminate inflorescence morphogenesis", "definition": "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can produce an undefined number of floral meristems. [GOC:jid]"}
{"concept_id": "C1326602", "aliases": ["epithelial polarization"], "types": ["T042"], "canonical_name": "morphogenesis of a polarized epithelium", "definition": "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. [GOC:dph]"}
{"concept_id": "C1326603", "aliases": ["anterior/posterior axis determination, follicular epithelium"], "types": ["T042"], "canonical_name": "anterior/posterior axis specification, follicular epithelium", "definition": "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis. [GOC:bf]"}
{"concept_id": "C1326604", "aliases": ["dorsal-ventral axis specification, ovarian follicular epithelium", "dorsal/ventral axis determination, ovarian follicular epithelium", "dorsoventral axis specification, ovarian follicular epithelium"], "types": ["T042"], "canonical_name": "dorsal/ventral axis specification, ovarian follicular epithelium", "definition": "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster. [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C1326605", "aliases": ["maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded", "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded", "maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded"], "types": ["T042"], "canonical_name": "maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded", "definition": "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1326606", "aliases": [], "types": ["T042"], "canonical_name": "female germ-line cyst encapsulation", "definition": "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad. [GOC:jid]"}
{"concept_id": "C1326607", "aliases": [], "types": ["T042"], "canonical_name": "germarium-derived female germ-line cyst encapsulation", "definition": "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11591336]"}
{"concept_id": "C1326608", "aliases": [], "types": ["T042"], "canonical_name": "germ-line cyst encapsulation", "definition": "Formation of a single follicular epithelium around the germ-line derived cells of a cyst. [GOC:jid]"}
{"concept_id": "C1326609", "aliases": [], "types": ["T042"], "canonical_name": "male germ-line cyst encapsulation", "definition": "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad. [GOC:jid, PMID:11591336]"}
{"concept_id": "C1326610", "aliases": ["organ boundary specification"], "types": ["T042"], "definition": "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. [GOC:dph, GOC:isa_complete, PMID:9611175]", "canonical_name": "formation of animal organ boundary"}
{"concept_id": "C1326611", "aliases": [], "types": ["T042"], "canonical_name": "endosperm development", "definition": "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo. [GOC:sm]"}
{"concept_id": "C1326615", "aliases": [], "types": ["T042"], "canonical_name": "Bolwig's organ morphogenesis", "definition": "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain. [PMID:6185380]"}
{"concept_id": "C1326618", "aliases": ["post-embryonic eye morphogenesis"], "types": ["T042"], "canonical_name": "post-embryonic eye morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight. [GOC:jid, GOC:sensu]"}
{"concept_id": "C1326619", "aliases": [], "types": ["T042"], "canonical_name": "uterine wall growth", "definition": "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels. [GOC:jl]"}
{"concept_id": "C1326620", "aliases": ["luteinizing hormone signalling pathway"], "types": ["T042"], "canonical_name": "luteinizing hormone signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by luteinizing hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:dph]"}
{"concept_id": "C1326621", "aliases": [], "types": ["T042"], "canonical_name": "ovulation from ovarian follicle", "definition": "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus. [GOC:mtg_sensu, https://www.ncbi.nlm.nih.gov/books/NBK279054/]"}
{"concept_id": "C1326622", "aliases": [], "types": ["T042"], "canonical_name": "embryonic heart tube development", "definition": "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. [GOC:go_curators]"}
{"concept_id": "C1326624", "aliases": ["vascular tissue histogenesis"], "types": ["T042"], "canonical_name": "phloem or xylem histogenesis", "definition": "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana. [GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C1326625", "aliases": ["phloem histogenesis"], "types": ["T042"], "canonical_name": "phloem development", "definition": "The formation of the principal food-conducting tissue of a vascular plant. [GOC:tb, ISBN:0471245208]"}
{"concept_id": "C1326626", "aliases": ["xylem histogenesis"], "types": ["T042"], "canonical_name": "xylem development", "definition": "The formation of the principal water-conducting tissue of a vascular plant. [GOC:tb, ISBN:0471245208]"}
{"concept_id": "C1326627", "aliases": [], "types": ["T042"], "canonical_name": "wing disc anterior/posterior pattern formation", "definition": "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing. [GOC:jid, PMID:10625531]"}
{"concept_id": "C1326628", "aliases": [], "types": ["T042"], "canonical_name": "anterior/posterior lineage restriction, imaginal disc", "definition": "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment. [GOC:jid, PMID:10625531, PMID:9374402]"}
{"concept_id": "C1326629", "aliases": ["wing disc dorsal-ventral pattern formation", "wing disc dorsoventral pattern formation"], "types": ["T042"], "canonical_name": "wing disc dorsal/ventral pattern formation", "definition": "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing. [GOC:jid]"}
{"concept_id": "C1326630", "aliases": [], "types": ["T042"], "canonical_name": "leaf morphogenesis", "definition": "The process in which the anatomical structures of the leaf are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1326631", "aliases": ["mammogenesis"], "types": ["T042"], "canonical_name": "mammary gland development", "definition": "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. [PMID:9576833]"}
{"concept_id": "C1326632", "aliases": [], "types": ["T042"], "canonical_name": "regulation of axonogenesis", "definition": "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. [GOC:ai]"}
{"concept_id": "C1326633", "aliases": ["down-regulation of axonogenesis", "downregulation of axonogenesis", "down regulation of axonogenesis"], "types": ["T042"], "canonical_name": "negative regulation of axonogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. [GOC:ai]"}
{"concept_id": "C1326634", "aliases": ["up regulation of axonogenesis", "up-regulation of axonogenesis", "upregulation of axonogenesis"], "types": ["T042"], "canonical_name": "positive regulation of axonogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of axonogenesis. [GOC:ai]"}
{"concept_id": "C1326635", "aliases": ["central body development"], "types": ["T042"], "canonical_name": "central complex development", "definition": "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli. [PMID:12490252]"}
{"concept_id": "C1326636", "aliases": ["prosencephalon development"], "types": ["T042"], "canonical_name": "forebrain development", "definition": "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain]"}
{"concept_id": "C1326637", "aliases": ["rhombencephalon development"], "types": ["T042"], "canonical_name": "hindbrain development", "definition": "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain]"}
{"concept_id": "C1326638", "aliases": ["mesencephalon development"], "types": ["T042"], "canonical_name": "midbrain development", "definition": "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain]"}
{"concept_id": "C1326639", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic plasticity", "definition": "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]"}
{"concept_id": "C1326640", "aliases": [], "types": ["T042"], "canonical_name": "regulation of neuronal synaptic plasticity", "definition": "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:jid, PMID:11891290]"}
{"concept_id": "C1326641", "aliases": [], "types": ["T042"], "canonical_name": "regulation of short-term neuronal synaptic plasticity", "definition": "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. [GOC:jid, PMID:11891290]"}
{"concept_id": "C1326642", "aliases": ["down-regulation of short-term neuronal synaptic plasticity", "down regulation of short-term neuronal synaptic plasticity", "downregulation of short-term neuronal synaptic plasticity"], "types": ["T042"], "canonical_name": "negative regulation of short-term neuronal synaptic plasticity", "definition": "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. [GOC:jid, PMID:11891290]"}
{"concept_id": "C1326643", "aliases": ["upregulation of short-term neuronal synaptic plasticity", "up-regulation of short-term neuronal synaptic plasticity", "up regulation of short-term neuronal synaptic plasticity"], "types": ["T042"], "canonical_name": "positive regulation of short-term neuronal synaptic plasticity", "definition": "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. [GOC:jid, PMID:11891290]"}
{"concept_id": "C1326644", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendrite development", "definition": "Any process that modulates the frequency, rate or extent of dendrite development. [GOC:ai]"}
{"concept_id": "C1326645", "aliases": ["down-regulation of dendrite morphogenesis", "down regulation of dendrite morphogenesis", "downregulation of dendrite morphogenesis"], "types": ["T043"], "canonical_name": "negative regulation of dendrite morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]"}
{"concept_id": "C1326646", "aliases": ["up regulation of dendrite morphogenesis", "upregulation of dendrite morphogenesis", "up-regulation of dendrite morphogenesis"], "types": ["T043"], "canonical_name": "positive regulation of dendrite morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]"}
{"concept_id": "C1326647", "aliases": [], "types": ["T042"], "canonical_name": "regulation of neurogenesis", "definition": "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. [GOC:ai]"}
{"concept_id": "C1326648", "aliases": ["downregulation of neurogenesis", "down-regulation of neurogenesis", "down regulation of neurogenesis"], "types": ["T042"], "canonical_name": "negative regulation of neurogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. [GOC:ai]"}
{"concept_id": "C1326649", "aliases": ["upregulation of neurogenesis", "up-regulation of neurogenesis", "up regulation of neurogenesis"], "types": ["T042"], "canonical_name": "positive regulation of neurogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. [GOC:ai]"}
{"concept_id": "C1326650", "aliases": [], "types": ["T042"], "canonical_name": "regulation of odontogenesis of calcareous or chitinous tooth"}
{"concept_id": "C1326651", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of odontogenesis of calcareous or chitinous tooth"}
{"concept_id": "C1326652", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of odontogenesis of calcareous or chitinous tooth"}
{"concept_id": "C1326653", "aliases": ["alveologenesis", "alveolarization"], "types": ["T042"], "canonical_name": "lung alveolus development", "definition": "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. [GOC:mtg_lung, PMID:9751757]"}
{"concept_id": "C1326654", "aliases": [], "types": ["T042"], "canonical_name": "specification of animal organ axis polarity", "definition": "The process in which the polarity of an animal organ axis is specified. [GOC:tb]"}
{"concept_id": "C1326655", "aliases": [], "types": ["T040"], "canonical_name": "polarity specification of proximal/distal axis", "definition": "Any process resulting in the establishment of polarity along the proximal/distal axis. [GOC:tb]"}
{"concept_id": "C1326656", "aliases": [], "types": ["T042"], "canonical_name": "specification of animal organ identity", "definition": "The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tb]"}
{"concept_id": "C1326657", "aliases": [], "types": ["T042"], "canonical_name": "specification of floral organ identity", "definition": "The process in which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tb]"}
{"concept_id": "C1326658", "aliases": [], "types": ["T042"], "canonical_name": "specification of carpel identity", "definition": "The process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tair_curators]"}
{"concept_id": "C1326659", "aliases": [], "types": ["T042"], "canonical_name": "specification of petal identity", "definition": "The process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tair_curators]"}
{"concept_id": "C1326660", "aliases": [], "types": ["T042"], "canonical_name": "specification of sepal identity", "definition": "The process in which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tair_curators]"}
{"concept_id": "C1326661", "aliases": [], "types": ["T042"], "canonical_name": "specification of stamen identity", "definition": "The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tair_curators]"}
{"concept_id": "C1326662", "aliases": [], "types": ["T040"], "canonical_name": "specification of animal organ position", "definition": "The regionalization process in which information that determines the correct position at which animal organ primordia are formed is generated and perceived resulting in correct positioning of the new animal organ. [GOC:curators]"}
{"concept_id": "C1326663", "aliases": [], "types": ["T040"], "canonical_name": "suspensor development", "definition": "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm. [GOC:tb, ISBN:0471245208]"}
{"concept_id": "C1326664", "aliases": [], "types": ["T042"], "canonical_name": "thyroid gland development", "definition": "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. [GOC:dgh]"}
{"concept_id": "C1326665", "aliases": [], "types": ["T042"], "canonical_name": "dorsal trunk growth"}
{"concept_id": "C1326666", "aliases": ["tracheal liquid clearance"], "types": ["T042"], "canonical_name": "liquid clearance, open tracheal system", "definition": "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system. [GOC:mtg_sensu, PMID:12571352]"}
{"concept_id": "C1326667", "aliases": [], "types": ["T042"], "canonical_name": "tracheal outgrowth, open tracheal system", "definition": "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1326668", "aliases": ["Wolffian body development"], "types": ["T042"], "canonical_name": "mesonephros development", "definition": "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314]"}
{"concept_id": "C1326669", "aliases": ["prostate development"], "types": ["T042"], "canonical_name": "prostate gland development", "definition": "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. [PMID:11839751]"}
{"concept_id": "C1326670", "aliases": [], "types": ["T040"], "canonical_name": "fruit morphogenesis", "definition": "The process in which the anatomical structures of a fruit are generated and organized. A fruit is a reproductive body of a seed plant. [GOC:sm]"}
{"concept_id": "C1326671", "aliases": [], "types": ["T040"], "canonical_name": "regulation of photomorphogenesis", "definition": "Any process that modulates the rate or extent of photomorphogenesis. [GOC:tb]"}
{"concept_id": "C1326672", "aliases": ["down-regulation of photomorphogenesis", "down regulation of photomorphogenesis", "downregulation of photomorphogenesis"], "types": ["T040"], "canonical_name": "negative regulation of photomorphogenesis", "definition": "Any process that stops, reduces or prevents photomorphogenesis. [GOC:tb]"}
{"concept_id": "C1326673", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic root morphogenesis", "definition": "The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed. [GOC:tb]"}
{"concept_id": "C1326674", "aliases": [], "types": ["T040"], "canonical_name": "lateral root morphogenesis", "definition": "The process in which the anatomical structures of a lateral root are generated and organized. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper. [GOC:tair_curators]"}
{"concept_id": "C1326675", "aliases": [], "types": ["T043"], "canonical_name": "sporocyte morphogenesis", "definition": "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores. [PMID:10465788]"}
{"concept_id": "C1326676", "aliases": [], "types": ["T040"], "definition": "The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support. [GOC:sm, ISBN:0877797099]", "canonical_name": "root morphogenesis"}
{"concept_id": "C1326677", "aliases": ["shoot morphogenesis"], "types": ["T040"], "canonical_name": "shoot system morphogenesis", "definition": "The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground. [GOC:sm, ISBN:0877797099]"}
{"concept_id": "C1326678", "aliases": [], "types": ["T040"], "canonical_name": "stomatal complex morphogenesis", "definition": "The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells. [GOC:tair_curators]"}
{"concept_id": "C1326693", "aliases": [], "types": ["T042"], "canonical_name": "cuticle pattern formation", "definition": "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle. [GOC:bf]"}
{"concept_id": "C1326694", "aliases": ["adult cuticle pattern formation"], "types": ["T042"], "canonical_name": "adult chitin-based cuticle pattern formation", "definition": "The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1326696", "aliases": ["determination of adaxial identity"], "types": ["T040"], "canonical_name": "determination of dorsal identity", "definition": "Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:jid]"}
{"concept_id": "C1326697", "aliases": ["determination of abaxial identity"], "types": ["T040"], "canonical_name": "determination of ventral identity", "definition": "The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:dph, GOC:isa_complete, GOC:jid]"}
{"concept_id": "C1326698", "aliases": ["determination of left/right asymmetry"], "types": ["T040"], "canonical_name": "determination of left/right symmetry", "definition": "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. [GOC:dph, GOC:jid]"}
{"concept_id": "C1326699", "aliases": [], "types": ["T040"], "canonical_name": "chorion-containing eggshell pattern formation", "definition": "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1326701", "aliases": ["vascular tissue pattern formation"], "types": ["T040"], "canonical_name": "xylem and phloem pattern formation", "definition": "The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana. [GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C1326703", "aliases": [], "types": ["T042"], "canonical_name": "cuticle pigmentation", "definition": "Establishment of a pattern of pigment in the cuticle of an organism. [GOC:jid]"}
{"concept_id": "C1326708", "aliases": [], "types": ["T042"], "canonical_name": "regulation of cuticle pigmentation", "definition": "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. [GOC:jid]"}
{"concept_id": "C1326709", "aliases": ["downregulation of cuticle pigmentation", "down-regulation of cuticle pigmentation", "down regulation of cuticle pigmentation"], "types": ["T042"], "canonical_name": "negative regulation of cuticle pigmentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. [GOC:jid]"}
{"concept_id": "C1326710", "aliases": ["up regulation of cuticle pigmentation", "up-regulation of cuticle pigmentation", "upregulation of cuticle pigmentation"], "types": ["T042"], "canonical_name": "positive regulation of cuticle pigmentation", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. [GOC:jid]"}
{"concept_id": "C1326711", "aliases": [], "types": ["T042"], "canonical_name": "eye pigmentation", "definition": "Establishment of a pattern of pigment in the eye of an organism. [GOC:jid]"}
{"concept_id": "C1326716", "aliases": [], "types": ["T042"], "canonical_name": "regulation of eye pigmentation", "definition": "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism. [GOC:jid]"}
{"concept_id": "C1326717", "aliases": ["down regulation of eye pigmentation", "inhibition of eye pigmentation", "negative regulation of eye pigmentation", "downregulation of eye pigmentation", "down-regulation of eye pigmentation"], "types": ["T042"], "canonical_name": "negative regulation of eye pigmentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism. [GOC:jid]"}
{"concept_id": "C1326718", "aliases": ["upregulation of eye pigmentation", "up regulation of eye pigmentation", "positive regulation of eye pigmentation", "activation of eye pigmentation", "up-regulation of eye pigmentation", "stimulation of eye pigmentation"], "types": ["T042"], "canonical_name": "positive regulation of eye pigmentation", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism. [GOC:jid]"}
{"concept_id": "C1326719", "aliases": ["heme O formation", "heme O biosynthesis", "haem O biosynthetic process", "heme O synthesis", "haem O biosynthesis", "heme O anabolism"], "types": ["T044"], "canonical_name": "heme O biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. [GOC:jid]"}
{"concept_id": "C1326720", "aliases": ["heme O catabolism", "haem O catabolism", "haem O catabolic process", "heme O degradation", "heme O breakdown"], "types": ["T044"], "canonical_name": "heme O catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. [GOC:jid]"}
{"concept_id": "C1326721", "aliases": ["haem O metabolism", "haem O metabolic process", "heme O metabolism"], "types": ["T044"], "canonical_name": "heme O metabolic process", "definition": "The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. [GOC:jid]"}
{"concept_id": "C1326722", "aliases": ["regulation of melanin anabolism", "regulation of melanin formation", "regulation of melanin synthesis", "regulation of melanin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of melanin biosynthetic process", "definition": "Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin. [GOC:jid]"}
{"concept_id": "C1326723", "aliases": ["down regulation of melanin biosynthetic process", "negative regulation of melanin biosynthesis", "down-regulation of melanin biosynthetic process", "downregulation of melanin biosynthetic process", "negative regulation of melanin formation", "negative regulation of melanin synthesis", "negative regulation of melanin anabolism"], "types": ["T044"], "canonical_name": "negative regulation of melanin biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin. [GOC:jid]"}
{"concept_id": "C1326724", "aliases": ["positive regulation of melanin synthesis", "positive regulation of melanin anabolism", "positive regulation of melanin biosynthesis", "up regulation of melanin biosynthetic process", "positive regulation of melanin formation", "upregulation of melanin biosynthetic process", "up-regulation of melanin biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of melanin biosynthetic process", "definition": "Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin. [GOC:jid]"}
{"concept_id": "C1326725", "aliases": ["melanization defence response"], "types": ["T046"], "canonical_name": "melanization defense response", "definition": "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin. [GOC:bf, PMID:12408809]"}
{"concept_id": "C1326726", "aliases": [], "types": ["T046"], "canonical_name": "melanotic encapsulation of foreign target", "definition": "Formation of a multilayered, melanized sheath of cells around a foreign invader. [GOC:bf]"}
{"concept_id": "C1326727", "aliases": ["regulation of melanization defence response"], "types": ["T046"], "canonical_name": "regulation of melanization defense response", "definition": "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion. [GOC:bf]"}
{"concept_id": "C1326728", "aliases": ["down-regulation of melanization defense response", "down regulation of melanization defense response", "negative regulation of melanization defence response", "downregulation of melanization defense response"], "types": ["T046"], "canonical_name": "negative regulation of melanization defense response", "definition": "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection. [GOC:bf, PMID:12408809]"}
{"concept_id": "C1326729", "aliases": ["upregulation of melanization defense response", "positive regulation of melanization defence response", "up-regulation of melanization defense response", "up regulation of melanization defense response"], "types": ["T040"], "canonical_name": "positive regulation of melanization defense response", "definition": "Any process that increases the rate or extent of the melanization defense response during injury or invasion. [GOC:bf]"}
{"concept_id": "C1326732", "aliases": ["downregulation of female pigmentation", "down regulation of female pigmentation", "down-regulation of female pigmentation"], "types": ["T040"], "canonical_name": "negative regulation of female pigmentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in females. [GOC:jid]"}
{"concept_id": "C1326733", "aliases": ["downregulation of male pigmentation", "down regulation of male pigmentation", "down-regulation of male pigmentation"], "types": ["T040"], "canonical_name": "negative regulation of male pigmentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males. [GOC:jid]"}
{"concept_id": "C1326735", "aliases": ["up regulation of female pigmentation", "up-regulation of female pigmentation", "upregulation of female pigmentation"], "types": ["T040"], "canonical_name": "positive regulation of female pigmentation", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females. [GOC:jid]"}
{"concept_id": "C1326736", "aliases": ["up regulation of male pigmentation", "up-regulation of male pigmentation", "upregulation of male pigmentation"], "types": ["T040"], "canonical_name": "positive regulation of male pigmentation", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males. [GOC:jid]"}
{"concept_id": "C1326737", "aliases": [], "types": ["T040"], "canonical_name": "regulation of female pigmentation", "definition": "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females. [GOC:jid]"}
{"concept_id": "C1326738", "aliases": [], "types": ["T040"], "canonical_name": "regulation of male pigmentation", "definition": "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males. [GOC:jid]"}
{"concept_id": "C1326739", "aliases": [], "types": ["T040"], "canonical_name": "sex-specific pigmentation", "definition": "Establishment of a pattern of pigment in one sex that is not observed in the other sex. [GOC:jid]"}
{"concept_id": "C1326740", "aliases": [], "types": ["T040"], "canonical_name": "female pigmentation", "definition": "Establishment of a pattern of pigment in females. [GOC:jid]"}
{"concept_id": "C1326741", "aliases": [], "types": ["T040"], "canonical_name": "male pigmentation", "definition": "Establishment of a pattern of pigment in males. [GOC:jid]"}
{"concept_id": "C1326742", "aliases": [], "types": ["T040"], "canonical_name": "acquisition of reproductive competence"}
{"concept_id": "C1326743", "aliases": [], "types": ["T040"], "canonical_name": "flower development", "definition": "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem. [GOC:tb, ISBN:0879015322]"}
{"concept_id": "C1326746", "aliases": [], "types": ["T042"], "canonical_name": "uterine wall breakdown", "definition": "The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels. [GOC:dph]"}
{"concept_id": "C1326747", "aliases": [], "types": ["T040"], "canonical_name": "vegetative phase change", "definition": "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development. [GOC:tb]"}
{"concept_id": "C1326749", "aliases": [], "types": ["T045"], "canonical_name": "DNA methylation involved in gamete generation", "definition": "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. [GOC:go_curators, PMID:12138111]"}
{"concept_id": "C1326750", "aliases": [], "types": ["T045"], "canonical_name": "dosage compensation complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes. [GOC:jl, PMID:11102361, PMID:12672493]"}
{"concept_id": "C1326751", "aliases": [], "types": ["T045"], "canonical_name": "dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome"}
{"concept_id": "C1326752", "aliases": [], "types": ["T045"], "canonical_name": "dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome"}
{"concept_id": "C1326754", "aliases": [], "types": ["T040"], "canonical_name": "sporocarp development involved in asexual reproduction", "definition": "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction. [GOC:clt, GOC:mtg_sensu]"}
{"concept_id": "C1326755", "aliases": [], "types": ["T040"], "canonical_name": "sporocarp development involved in sexual reproduction", "definition": "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi. [GOC:clt, GOC:mtg_sensu]"}
{"concept_id": "C1326756", "aliases": [], "types": ["T043"], "canonical_name": "centrosomal and pronuclear rotation", "definition": "The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion. [GOC:bf, ISBN:087969307X, PMID:10085292]"}
{"concept_id": "C1326757", "aliases": [], "types": ["T043"], "canonical_name": "male pronucleus formation"}
{"concept_id": "C1326758", "aliases": [], "types": ["T043"], "canonical_name": "sperm nuclear envelope removal", "definition": "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus. [GOC:bf, PMID:11735001]"}
{"concept_id": "C1326759", "aliases": [], "types": ["T043"], "canonical_name": "pronuclear migration", "definition": "The directed movement of the male and female pronuclei towards each other prior to their fusion. [GOC:bf, PMID:9199363]"}
{"concept_id": "C1326760", "aliases": [], "types": ["T043"], "canonical_name": "sperm entry", "definition": "An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur. [GOC:bf, PMID:9630751]"}
{"concept_id": "C1326761", "aliases": ["sperm plasma membrane breakdown", "sperm plasma membrane degradation", "sperm plasma membrane catabolism"], "types": ["T043"], "canonical_name": "sperm plasma membrane disassembly", "definition": "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1326762", "aliases": [], "types": ["T043"], "canonical_name": "sperm-egg recognition", "definition": "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. [GOC:bf]"}
{"concept_id": "C1326763", "aliases": ["female gamete generation"], "types": ["T043"], "canonical_name": "female gamete generation", "definition": "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. [GOC:dph, ISBN:0198506732]"}
{"concept_id": "C1326764", "aliases": ["eggshell formation"], "types": ["T042"], "canonical_name": "eggshell formation", "definition": "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration. [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261]"}
{"concept_id": "C1326765", "aliases": [], "types": ["T042"], "canonical_name": "chorion-containing eggshell formation", "definition": "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1326766", "aliases": [], "types": ["T042"], "canonical_name": "dorsal appendage formation", "definition": "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration. [ISBN:0879694238]"}
{"concept_id": "C1326767", "aliases": [], "types": ["T042"], "canonical_name": "chorion micropyle formation", "definition": "Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization. [ISBN:0879694238]"}
{"concept_id": "C1326768", "aliases": ["vitelline membrane formation in chorion-containing eggshell"], "types": ["T042"], "canonical_name": "vitelline membrane formation involved in chorion-containing eggshell formation", "definition": "Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1326769", "aliases": [], "types": ["T042"], "canonical_name": "vitelline membrane formation", "definition": "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg. [ISBN:0879694238]"}
{"concept_id": "C1326771", "aliases": ["female germline cyst formation"], "types": ["T042"], "canonical_name": "female germ-line cyst formation", "definition": "Formation of a group of interconnected cells derived from a single female gonial founder cell. [GOC:jid, PMID:10370240]"}
{"concept_id": "C1326772", "aliases": ["germarium-derived female germline cyst formation"], "types": ["T042"], "canonical_name": "germarium-derived female germ-line cyst formation", "definition": "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:10370240, PMID:9442902]"}
{"concept_id": "C1326775", "aliases": [], "types": ["T042"], "canonical_name": "germarium-derived egg chamber formation", "definition": "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1326778", "aliases": [], "types": ["T042"], "canonical_name": "ovarian ring canal formation"}
{"concept_id": "C1326779", "aliases": ["egg chamber growth"], "types": ["T042"], "canonical_name": "growth of a germarium-derived egg chamber", "definition": "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1326780", "aliases": [], "types": ["T042"], "canonical_name": "ovarian nurse cell to oocyte transport", "definition": "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C1326781", "aliases": [], "types": ["T042"], "canonical_name": "ovarian ring canal stabilization"}
{"concept_id": "C1326782", "aliases": [], "types": ["T042"], "canonical_name": "ovarian follicle cell development", "definition": "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:10822261]"}
{"concept_id": "C1326783", "aliases": [], "types": ["T044"], "canonical_name": "border follicle cell delamination", "definition": "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration. [PMID:10822261]"}
{"concept_id": "C1326784", "aliases": [], "types": ["T038"], "canonical_name": "regulation of border cell delamination"}
{"concept_id": "C1326785", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of border cell delamination"}
{"concept_id": "C1326786", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of border cell delamination"}
{"concept_id": "C1326787", "aliases": ["ovarian follicle cell adhesion", "follicle cell adhesion"], "types": ["T043"], "canonical_name": "ovarian follicle cell-cell adhesion", "definition": "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu, PMID:12642496]"}
{"concept_id": "C1326790", "aliases": ["mammalian oogenesis stage 7"], "types": ["T042"], "canonical_name": "distinct antral spaces stage", "definition": "The stage in oogenesis when the antral spaces become distinct and the first polar body forms. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]"}
{"concept_id": "C1326791", "aliases": ["mammalian oogenesis stage 4"], "types": ["T042"], "canonical_name": "double layer follicle stage", "definition": "The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]"}
{"concept_id": "C1326792", "aliases": ["mammalian oogenesis stage 8"], "types": ["T042"], "canonical_name": "fused antrum stage", "definition": "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]"}
{"concept_id": "C1326793", "aliases": ["mammalian oogenesis stage 9"], "types": ["T042"], "canonical_name": "mature follicle stage", "definition": "The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]"}
{"concept_id": "C1326794", "aliases": ["mammalian oogenesis stage 5"], "types": ["T042"], "canonical_name": "multi-layer follicle stage", "definition": "The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]"}
{"concept_id": "C1326795", "aliases": ["mammalian oogenesis stage 1"], "types": ["T042"], "canonical_name": "oogonium stage", "definition": "The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]"}
{"concept_id": "C1326796", "aliases": ["mammalian oogenesis stage 3"], "types": ["T042"], "canonical_name": "primary follicle stage", "definition": "The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]"}
{"concept_id": "C1326797", "aliases": ["mammalian oogenesis stage 2"], "types": ["T042"], "canonical_name": "primary oocyte stage", "definition": "The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]"}
{"concept_id": "C1326798", "aliases": ["mammalian oogenesis stage 6"], "types": ["T042"], "canonical_name": "scattered antral spaces stage", "definition": "The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]"}
{"concept_id": "C1326800", "aliases": [], "types": ["T042"], "canonical_name": "polar nucleus fusion", "definition": "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized. [GOC:mtg_plant, GOC:sm]"}
{"concept_id": "C1326803", "aliases": [], "types": ["T042"], "canonical_name": "pollen maturation", "definition": "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains. [PMID:11595796]"}
{"concept_id": "C1326804", "aliases": ["pollen wall formation"], "types": ["T042"], "canonical_name": "pollen wall assembly", "definition": "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine. [PMID:11743117]"}
{"concept_id": "C1326805", "aliases": ["germline cyst formation"], "types": ["T042"], "canonical_name": "germ-line cyst formation", "definition": "Formation of a group of interconnected cells derived from a single gonial founder cell. [GOC:jid, PMID:10370240, PMID:21681920]"}
{"concept_id": "C1326806", "aliases": ["male germline cyst formation"], "types": ["T042"], "canonical_name": "male germ-line cyst formation", "definition": "Formation of a group of interconnected cells derived from a single male gonial founder cell. [GOC:jid, PMID:10370240]"}
{"concept_id": "C1326807", "aliases": ["spermatocyte cell division"], "types": ["T043"], "canonical_name": "spermatocyte division", "definition": "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids. [GOC:jid, GOC:pr, ISBN:0879694238]"}
{"concept_id": "C1326808", "aliases": ["male gamete generation"], "types": ["T043"], "canonical_name": "male gamete generation", "definition": "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. [GOC:dph, GOC:jid]"}
{"concept_id": "C1326809", "aliases": [], "types": ["T042"], "canonical_name": "testicular ring canal formation"}
{"concept_id": "C1326810", "aliases": ["gametophyte development"], "types": ["T040"], "definition": "The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. An example of this process is found in Arabidopsis thaliana. [GOC:jid, PO:0009004]", "canonical_name": "gametogenesis"}
{"concept_id": "C1326813", "aliases": [], "types": ["T040"], "canonical_name": "germ-line stem cell population maintenance", "definition": "Any process by which an organism or tissue maintains a population of germ-line stem cells. [ISBN:0879694238]"}
{"concept_id": "C1326814", "aliases": [], "types": ["T040"], "canonical_name": "somatic stem cell population maintenance", "definition": "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. [GOC:bf, ISBN:0582227089]"}
{"concept_id": "C1326829", "aliases": ["actin cytoskeleton remodeling", "actin cytoskeleton reorganisation"], "types": ["T043"], "canonical_name": "actin cytoskeleton reorganization", "definition": "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:ecd, GOC:mah]"}
{"concept_id": "C1326841", "aliases": ["adenine, hypoxanthine and their nucleoside salvage"], "types": ["T044"], "canonical_name": "adenine, hypoxanthine and their nucleoside salvage", "definition": "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis. [GOC:pz]"}
{"concept_id": "C1326843", "aliases": [], "types": ["T044"], "canonical_name": "alanine racemization", "definition": "OBSOLETE. (Was not defined before being made obsolete). [RESID:AA0191]"}
{"concept_id": "C1326844", "aliases": ["allantoin/allantoate transport"], "types": ["T043"], "canonical_name": "allantoin/allantoate transport", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326847", "aliases": ["anaerobic toluene formation", "anaerobic toluene biosynthesis", "anaerobic toluene synthesis", "anaerobic toluene anabolism"], "types": ["T044"], "canonical_name": "anaerobic toluene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen. [GOC:ai, PMID:8573493]"}
{"concept_id": "C1326848", "aliases": [], "types": ["T043"], "canonical_name": "antibiotic susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326849", "aliases": [], "types": ["T044"], "canonical_name": "arsenate sensitivity/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326851", "aliases": [], "types": ["T043"], "canonical_name": "bacteriocin susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326857", "aliases": [], "types": ["T038"], "canonical_name": "cadmium sensitivity/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326858", "aliases": [], "types": ["T043"], "canonical_name": "carbamate resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326859", "aliases": [], "types": ["T038"], "canonical_name": "carbamate susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326862", "aliases": [], "types": ["T038"], "canonical_name": "chromate sensitivity/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326864", "aliases": [], "types": ["T038"], "canonical_name": "copper sensitivity/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326866", "aliases": [], "types": ["T043"], "canonical_name": "cyclodiene resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326867", "aliases": [], "types": ["T038"], "canonical_name": "cyclodiene susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326868", "aliases": [], "types": ["T043"], "canonical_name": "DDT resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326869", "aliases": [], "types": ["T038"], "canonical_name": "DDT susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1326870", "aliases": [], "types": ["T038"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "drought tolerance"}
{"concept_id": "C1326871", "aliases": [], "types": ["T040"], "canonical_name": "drug susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1326872", "aliases": ["embryogenesis and morphogenesis"], "types": ["T042"], "canonical_name": "embryogenesis and morphogenesis", "definition": "OBSOLETE. Formation and development of an embryo and its organized structures. [GOC:ems, ISBN:0070524300, ISBN:0140512888]"}
{"concept_id": "C1326875", "aliases": ["freezing tolerance"], "types": ["T038"], "canonical_name": "freezing tolerance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326877", "aliases": ["GPI/GSI anchor biosynthesis", "GPI/GSI anchor biosynthetic process"], "types": ["T044"], "canonical_name": "GPI/GSI anchor biosynthesis", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1326878", "aliases": ["GPI/GSI anchor metabolism"], "types": ["T044"], "canonical_name": "GPI/GSI anchor metabolism"}
{"concept_id": "C1326879", "aliases": ["guanine, xanthine and their nucleoside salvage"], "types": ["T044"], "canonical_name": "guanine, xanthine and their nucleoside salvage", "definition": "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis. [GOC:pz]"}
{"concept_id": "C1326880", "aliases": [], "types": ["T043"], "canonical_name": "heavy metal sensitivity/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326881", "aliases": [], "types": ["T038"], "canonical_name": "herbicide susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326882", "aliases": ["histogenesis and organogenesis"], "types": ["T042"], "canonical_name": "histogenesis and organogenesis", "definition": "OBSOLETE. The generation of organized tissues or of whole organs. [GOC:ems]"}
{"concept_id": "C1326886", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis by p53", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326887", "aliases": ["inositol phospholipid-mediated signaling"], "types": ["T044"], "canonical_name": "inositol phospholipid-mediated signaling", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ceb]"}
{"concept_id": "C1326888", "aliases": [], "types": ["T038"], "canonical_name": "insecticide susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326893", "aliases": ["lytic viral life cycle"], "types": ["T043"], "canonical_name": "lytic viral life cycle", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326898", "aliases": [], "types": ["T038"], "canonical_name": "mercuric sensitivity/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326899", "aliases": ["methionine and threonine metabolism"], "types": ["T044"], "canonical_name": "methionine and threonine metabolism"}
{"concept_id": "C1326901", "aliases": [], "types": ["T043"], "canonical_name": "microtubule depolymerization during nuclear congression", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:elh]"}
{"concept_id": "C1326902", "aliases": [], "types": ["T043"], "canonical_name": "mitotic sister-chromatid adhesion release", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1326903", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of crystal formation", "definition": "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the spontaneous (nonenzymatic) formation of crystals in a solution, for example, calcium oxalate crystals in urine. [GOC:ai]"}
{"concept_id": "C1326904", "aliases": ["neurotransmitter biosynthetic process and storage"], "types": ["T044"], "definition": "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules. [GOC:go_curators, ISBN:0123668387]", "canonical_name": "neurotransmitter biosynthesis and storage"}
{"concept_id": "C1326913", "aliases": [], "types": ["T043"], "canonical_name": "organophosphorus resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326914", "aliases": [], "types": ["T038"], "canonical_name": "organophosphorus susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326915", "aliases": [], "types": ["T044"], "canonical_name": "other pathways of electron transport", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326918", "aliases": ["peptidyl-aspartic acid/asparagine hydroxylation"], "types": ["T044"], "canonical_name": "peptidyl-aspartic acid/asparagine hydroxylation", "definition": "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine. [GOC:ai]"}
{"concept_id": "C1326919", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-prolyl isomerase B reaction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326922", "aliases": [], "types": ["T043"], "canonical_name": "phototransduction, visible light, light adaptation", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1326923", "aliases": [], "types": ["T044"], "canonical_name": "phototrophin mediated phototransduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326927", "aliases": [], "types": ["T043"], "canonical_name": "pyrethroid resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326928", "aliases": [], "types": ["T038"], "canonical_name": "pyrethroid susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326930", "aliases": ["pyrimidine-dimer repair, DNA damage recognition"], "types": ["T045"], "canonical_name": "pyrimidine-dimer repair, DNA damage recognition", "definition": "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers. [ISBN:0815316194]"}
{"concept_id": "C1326935", "aliases": [], "types": ["T043"], "canonical_name": "resistance to pathogenic protozoa", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326936", "aliases": [], "types": ["T038"], "canonical_name": "shmoo orientation", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:elh]"}
{"concept_id": "C1326937", "aliases": [], "types": ["T040"], "canonical_name": "sigma virus replication", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326939", "aliases": ["sodium/potassium transport"], "types": ["T043"], "canonical_name": "sodium/potassium transport", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326940", "aliases": [], "types": ["T038"], "canonical_name": "streptomycin susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326942", "aliases": [], "types": ["T038"], "canonical_name": "tellurium sensitivity/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326946", "aliases": ["toluene formation", "toluene anabolism", "toluene biosynthesis", "toluene synthesis"], "types": ["T044"], "canonical_name": "toluene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products. [GOC:ai, PMID:6508079]"}
{"concept_id": "C1326948", "aliases": [], "types": ["T046"], "canonical_name": "toxin susceptibility/resistance", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1326954", "aliases": ["regulation of clotting"], "types": ["T039"], "canonical_name": "regulation of coagulation", "definition": "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. [GOC:ai]"}
{"concept_id": "C1326956", "aliases": ["positive regulation of clotting", "up regulation of coagulation", "up-regulation of coagulation", "upregulation of coagulation"], "types": ["T039"], "canonical_name": "positive regulation of coagulation", "definition": "Any process that activates or increases the frequency, rate or extent of coagulation. [GOC:ai]"}
{"concept_id": "C1326957", "aliases": ["extracellular structure organisation", "extracellular structure organization and biogenesis"], "types": ["T039"], "canonical_name": "extracellular structure organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1326958", "aliases": ["intercellular bridge organization and biogenesis", "intercellular bridge organisation"], "types": ["T039"], "canonical_name": "intercellular bridge organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another. [GOC:jid]"}
{"concept_id": "C1326959", "aliases": [], "types": ["T042"], "canonical_name": "ring canal formation"}
{"concept_id": "C1326960", "aliases": [], "types": ["T039"], "definition": "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]", "canonical_name": "cholesterol homeostasis"}
{"concept_id": "C1326961", "aliases": [], "types": ["T039"], "definition": "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]", "canonical_name": "glucose homeostasis"}
{"concept_id": "C1326962", "aliases": [], "types": ["T039"], "canonical_name": "ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of ions within an organism or cell. [GOC:ai]"}
{"concept_id": "C1326963", "aliases": [], "types": ["T040"], "canonical_name": "body fluid osmoregulation"}
{"concept_id": "C1326964", "aliases": ["regulation of surface tension of a liquid"], "types": ["T039"], "canonical_name": "regulation of liquid surface tension", "definition": "Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid. [ISBN:0198506732]"}
{"concept_id": "C1326965", "aliases": ["glycol synthesis", "glycol anabolism", "glycol biosynthesis", "glycol formation"], "types": ["T044"], "canonical_name": "glycol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent. [GOC:curators]"}
{"concept_id": "C1326966", "aliases": ["D-ribose biosynthesis", "D-ribose synthesis", "D-ribose formation", "D-ribose anabolism"], "types": ["T044"], "canonical_name": "D-ribose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose). [ISBN:0198506732]"}
{"concept_id": "C1326967", "aliases": ["eugenol anabolism", "4-allyl-2-methoxyphenol biosynthesis", "eugenol biosynthesis", "eugenic acid biosynthesis", "4-allyl-2-methoxyphenol biosynthetic process", "eugenic acid biosynthetic process", "eugenol synthesis", "eugenol formation"], "types": ["T044"], "canonical_name": "eugenol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil. [GOC:jl]"}
{"concept_id": "C1326968", "aliases": ["glycol breakdown", "glycol degradation", "glycol catabolism"], "types": ["T044"], "canonical_name": "glycol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent. [Wikipedia:Ethylene_glycol]"}
{"concept_id": "C1326969", "aliases": ["D-ribose degradation", "D-ribose catabolism", "D-ribose breakdown"], "types": ["T044"], "canonical_name": "D-ribose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose). [ISBN:0198506732]"}
{"concept_id": "C1326970", "aliases": ["glycol metabolism"], "types": ["T044"], "canonical_name": "glycol metabolic process", "definition": "The chemical reactions and pathways involving glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent. [PMID:9851711]"}
{"concept_id": "C1326971", "aliases": ["L-sorbose biosynthesis", "L-sorbose synthesis", "L-sorbose anabolism", "L-sorbose formation"], "types": ["T044"], "canonical_name": "L-sorbose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol. [ISBN:0198506732]"}
{"concept_id": "C1326972", "aliases": ["L-sorbose catabolism", "L-sorbose degradation", "L-sorbose breakdown"], "types": ["T044"], "canonical_name": "L-sorbose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. [GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1326973", "aliases": ["sorbose anabolism", "sorbose formation", "sorbose synthesis", "sorbose biosynthesis"], "types": ["T044"], "canonical_name": "sorbose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. [ISBN:0198506732]"}
{"concept_id": "C1326974", "aliases": ["sorbose degradation", "sorbose breakdown", "sorbose catabolism"], "types": ["T044"], "canonical_name": "sorbose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. [ISBN:0198506732]"}
{"concept_id": "C1326975", "aliases": ["D-ribose metabolism"], "types": ["T044"], "canonical_name": "D-ribose metabolic process", "definition": "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. [ISBN:0198506732]"}
{"concept_id": "C1326976", "aliases": ["D-xylose metabolism"], "types": ["T044"], "canonical_name": "D-xylose metabolic process", "definition": "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide. [ISBN:0198506732]"}
{"concept_id": "C1326977", "aliases": ["D-xylose formation", "D-xylose anabolism", "D-xylose synthesis", "D-xylose biosynthesis"], "types": ["T044"], "canonical_name": "D-xylose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide. [ISBN:0198506732]"}
{"concept_id": "C1326978", "aliases": ["D-xylose breakdown", "D-xylose catabolism", "D-xylose degradation"], "types": ["T044"], "canonical_name": "D-xylose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide. [ISBN:0198506732]"}
{"concept_id": "C1326979", "aliases": ["4-allyl-2-methoxyphenol metabolism", "eugenic acid metabolism", "eugenol metabolism", "eugenic acid metabolic process", "4-allyl-2-methoxyphenol metabolic process"], "types": ["T044"], "canonical_name": "eugenol metabolic process", "definition": "The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil. [GOC:jl]"}
{"concept_id": "C1326980", "aliases": ["eugenol breakdown", "eugenic acid catabolism", "4-allyl-2-methoxyphenol catabolic process", "eugenic acid catabolic process", "eugenol degradation", "eugenol catabolism", "4-allyl-2-methoxyphenol catabolism"], "types": ["T044"], "canonical_name": "eugenol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil. [GOC:jl]"}
{"concept_id": "C1326981", "aliases": ["L-phenylalanine synthesis", "L-phenylalanine formation", "L-phenylalanine biosynthesis", "L-phenylalanine anabolism"], "types": ["T044"], "canonical_name": "L-phenylalanine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. [GOC:jsg, GOC:mah]"}
{"concept_id": "C1326982", "aliases": ["hydroxylysine biosynthesis", "hydroxylysine anabolism", "hydroxylysine formation", "hydroxylysine synthesis"], "types": ["T044"], "canonical_name": "hydroxylysine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. [ISBN:0198506732]"}
{"concept_id": "C1326983", "aliases": ["L-alanine formation", "L-alanine synthesis", "L-alanine anabolism", "L-alanine biosynthesis"], "types": ["T044"], "canonical_name": "L-alanine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C1326984", "aliases": ["L-alanine formation from pyruvate", "L-alanine synthesis from pyruvate", "L-alanine anabolism from pyruvate"], "types": ["T044"], "canonical_name": "L-alanine biosynthetic process from pyruvate", "definition": "The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate. [GOC:go_curators]"}
{"concept_id": "C1326985", "aliases": ["L-alanine synthesis via ornithine", "L-alanine formation via ornithine", "L-alanine anabolism via ornithine"], "types": ["T044"], "canonical_name": "L-alanine biosynthetic process via ornithine", "definition": "The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine. [GOC:go_curators]"}
{"concept_id": "C1326986", "aliases": ["L-serine synthesis", "L-serine biosynthesis", "L-serine formation", "L-serine anabolism"], "types": ["T044"], "canonical_name": "L-serine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg]"}
{"concept_id": "C1326987", "aliases": ["hydroxylysine catabolism", "hydroxylysine degradation", "hydroxylysine breakdown"], "types": ["T044"], "canonical_name": "hydroxylysine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. [ISBN:0198506732]"}
{"concept_id": "C1326988", "aliases": ["arginine degradation to alanine via ornithine", "arginine breakdown to alanine via ornithine"], "types": ["T044"], "canonical_name": "arginine catabolic process to alanine via ornithine", "definition": "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine. [GOC:pz]"}
{"concept_id": "C1326989", "aliases": ["arginine breakdown to proline via ornithine", "arginine degradation to proline via ornithine"], "types": ["T044"], "canonical_name": "arginine catabolic process to proline via ornithine", "definition": "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine. [GOC:pz]"}
{"concept_id": "C1326990", "aliases": ["proline degradation to glutamate", "proline breakdown to glutamate"], "types": ["T044"], "canonical_name": "proline catabolic process to glutamate", "definition": "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate. [GOC:pz]"}
{"concept_id": "C1326992", "aliases": ["L-alanine catabolism", "L-alanine degradation", "L-alanine breakdown"], "types": ["T044"], "canonical_name": "L-alanine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C1326993", "aliases": ["L-alanine breakdown, by transamination", "L-alanine degradation, by transamination"], "types": ["T044"], "canonical_name": "L-alanine catabolic process, by transamination", "definition": "The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination. [GOC:go_curators]"}
{"concept_id": "C1326994", "aliases": ["L-alanine fermentation"], "types": ["T044"], "canonical_name": "anaerobic L-alanine catabolic process", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP. [GOC:jl]"}
{"concept_id": "C1326996", "aliases": [], "types": ["T044"], "canonical_name": "L-alanine oxidation to pyruvate via D-alanine", "definition": "The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate. [MetaCyc:ALADEG-PWY]"}
{"concept_id": "C1326997", "aliases": ["L-serine catabolism", "L-serine degradation", "L-serine breakdown"], "types": ["T044"], "canonical_name": "L-serine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg]"}
{"concept_id": "C1326998", "aliases": [], "types": ["T045"], "canonical_name": "nonribosomal amino acid activation"}
{"concept_id": "C1326999", "aliases": ["amino acid adenylation by nonribosomal peptide synthase", "amino acid adenylation by NRPS"], "types": ["T045"], "canonical_name": "amino acid adenylylation by nonribosomal peptide synthase", "definition": "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor. [GOC:jl, PMID:9250661, PMID:9712910]"}
{"concept_id": "C1327000", "aliases": ["tRNA aminoacylation for nonribosomal peptide formation", "tRNA aminoacylation for nonribosomal peptide synthesis", "tRNA aminoacylation for nonribosomal peptide biosynthesis", "tRNA aminoacylation for nonribosomal peptide anabolism"], "types": ["T045"], "canonical_name": "tRNA aminoacylation for nonribosomal peptide biosynthetic process", "definition": "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis. [GOC:jl]"}
{"concept_id": "C1327001", "aliases": ["aminoacyl-tRNA biosynthesis", "aminoacyl-tRNA biosynthetic process", "tRNA aminoacylation"], "types": ["T045"], "definition": "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]", "canonical_name": "tRNA charging"}
{"concept_id": "C1327002", "aliases": [], "types": ["T045"], "definition": "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. [GOC:ma]", "canonical_name": "tRNA aminoacylation for protein translation"}
{"concept_id": "C1327003", "aliases": [], "types": ["T044"], "canonical_name": "amino acid salvage", "definition": "Any process which produces an amino acid from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1327004", "aliases": ["L-phenylalanine metabolic process", "phenylalanine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. [GOC:jsg, GOC:mah]", "canonical_name": "L-phenylalanine metabolism"}
{"concept_id": "C1327005", "aliases": ["hydroxylysine metabolism"], "types": ["T044"], "canonical_name": "hydroxylysine metabolic process", "definition": "The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases. [ISBN:0198506732, PubChem_Compound:1029]"}
{"concept_id": "C1327006", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine racemization", "definition": "The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine. [PMID:12696888]"}
{"concept_id": "C1327007", "aliases": ["L-alanine metabolism"], "types": ["T044"], "canonical_name": "L-alanine metabolic process", "definition": "The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C1327008", "aliases": ["L-serine metabolism"], "types": ["T044"], "canonical_name": "L-serine metabolic process", "definition": "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg]"}
{"concept_id": "C1327009", "aliases": ["Hcy metabolism", "homocysteine metabolism", "Hcy metabolic process"], "types": ["T044"], "canonical_name": "homocysteine metabolic process", "definition": "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. [ISBN:0198506732]"}
{"concept_id": "C1327010", "aliases": ["regulation of Hcy metabolic process", "regulation of Hcy metabolism", "regulation of homocysteine metabolism"], "types": ["T044"], "canonical_name": "regulation of homocysteine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. [GOC:ai]"}
{"concept_id": "C1327011", "aliases": ["negative regulation of Hcy metabolism", "downregulation of homocysteine metabolic process", "negative regulation of Hcy metabolic process", "negative regulation of homocysteine metabolism", "down regulation of homocysteine metabolic process", "down-regulation of homocysteine metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of homocysteine metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine. [GOC:ai]"}
{"concept_id": "C1327012", "aliases": ["positive regulation of Hcy metabolism", "up-regulation of homocysteine metabolic process", "up regulation of homocysteine metabolic process", "positive regulation of Hcy metabolic process", "upregulation of homocysteine metabolic process", "positive regulation of homocysteine metabolism"], "types": ["T044"], "canonical_name": "positive regulation of homocysteine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine. [GOC:ai]"}
{"concept_id": "C1327013", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine sulfation", "definition": "The sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine. [RESID:AA0361]"}
{"concept_id": "C1327015", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine sulfation", "definition": "The sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine. [RESID:AA0362]"}
{"concept_id": "C1327017", "aliases": ["proanthocyanidin biosynthesis", "proanthocyanidin synthesis", "proanthocyanidin anabolism", "proanthocyanidin formation"], "types": ["T044"], "canonical_name": "proanthocyanidin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of proanthocyanidin. [GOC:lm]"}
{"concept_id": "C1327018", "aliases": ["regulation of flavonoid synthesis", "regulation of flavonoid formation", "regulation of flavonoid biosynthesis", "regulation of flavonoid anabolism"], "types": ["T044"], "canonical_name": "regulation of flavonoid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. [GOC:tb]"}
{"concept_id": "C1327019", "aliases": ["negative regulation of flavonoid anabolism", "down-regulation of flavonoid biosynthetic process", "negative regulation of flavonoid biosynthesis", "negative regulation of flavonoid formation", "downregulation of flavonoid biosynthetic process", "negative regulation of flavonoid synthesis", "down regulation of flavonoid biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of flavonoid biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. [GOC:tb]"}
{"concept_id": "C1327020", "aliases": ["positive regulation of flavonoid biosynthesis", "positive regulation of flavonoid synthesis", "positive regulation of flavonoid anabolism", "upregulation of flavonoid biosynthetic process", "up-regulation of flavonoid biosynthetic process", "up regulation of flavonoid biosynthetic process", "positive regulation of flavonoid formation"], "types": ["T044"], "canonical_name": "positive regulation of flavonoid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. [GOC:tb]"}
{"concept_id": "C1327021", "aliases": ["S-adenosylmethionine breakdown", "S-adenosylmethionine catabolism", "S-adenosylmethionine degradation", "SAM catabolic process", "S-adenosyl methionine catabolic process", "S-adenosyl methionine catabolism"], "types": ["T044"], "canonical_name": "S-adenosylmethionine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. [GOC:ai]"}
{"concept_id": "C1327022", "aliases": [], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide", "definition": "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide. [RESID:AA0356]"}
{"concept_id": "C1327023", "aliases": ["anaerobic cyclohexane-1-carboxylate breakdown", "anaerobic cyclohexane-1-carboxylate degradation", "anaerobic cyclohexane-1-carboxylate catabolism"], "types": ["T044"], "canonical_name": "anaerobic cyclohexane-1-carboxylate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen. [GOC:pz]"}
{"concept_id": "C1327024", "aliases": [], "types": ["T044"], "canonical_name": "ortho-cleavage pathway"}
{"concept_id": "C1327025", "aliases": ["phenylacetate catabolism", "phenylacetate breakdown", "phenylacetate degradation"], "types": ["T044"], "canonical_name": "phenylacetate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phenylacetate. [GOC:pz]"}
{"concept_id": "C1327026", "aliases": ["anaerobic benzoate catabolic process", "anaerobic benzoate breakdown", "anaerobic benzoate catabolism", "anaerobic benzoate degradation"], "types": ["T044"], "canonical_name": "benzoate catabolic process via CoA ligation", "definition": "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway. [GOC:pz]"}
{"concept_id": "C1327027", "aliases": ["anaerobic ethylbenzene catabolism", "anaerobic ethylbenzene breakdown", "anaerobic ethylbenzene degradation"], "types": ["T044"], "canonical_name": "anaerobic ethylbenzene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen. [GOC:pz]"}
{"concept_id": "C1327028", "aliases": ["tetrahydrofolyl-[Glu](n) biosynthetic process", "THF polyglutamylation", "tetrahydrofolylpolyglutamate anabolism", "tetrahydrofolyl-[Glu](n) biosynthesis", "tetrahydrofolylpolyglutamate formation", "tetrahydrofolate polyglutamylation", "tetrahydrofolylpolyglutamate biosynthesis", "tetrahydrofolylpolyglutamate synthesis"], "types": ["T044"], "canonical_name": "tetrahydrofolylpolyglutamate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues. [GOC:ai]"}
{"concept_id": "C1327029", "aliases": ["tetrahydrofolyl-[Glu](n) metabolism", "tetrahydrofolyl-[Glu](n) metabolic process", "tetrahydrofolylpolyglutamate metabolism"], "types": ["T044"], "canonical_name": "tetrahydrofolylpolyglutamate metabolic process", "definition": "The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues. [GOC:ai]"}
{"concept_id": "C1327030", "aliases": ["camalexin synthesis", "camalexin formation", "camalexin biosynthesis", "camalexin anabolism"], "types": ["T044"], "canonical_name": "camalexin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin. [GOC:pz]"}
{"concept_id": "C1327031", "aliases": [], "types": ["T044"], "canonical_name": "hypoxanthine salvage", "definition": "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1327032", "aliases": ["purine base salvage"], "types": ["T044"], "canonical_name": "purine nucleobase salvage", "definition": "Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1327033", "aliases": ["pyrimidine base salvage"], "types": ["T044"], "canonical_name": "pyrimidine nucleobase salvage", "definition": "Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1327034", "aliases": ["epothilone anabolism", "epothilone synthesis", "epothilone biosynthesis", "epothilone formation"], "types": ["T044"], "canonical_name": "epothilone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer. [GOC:ai]"}
{"concept_id": "C1327035", "aliases": ["paclitaxel biosynthesis", "paclitaxel anabolism", "paclitaxel formation", "paclitaxel synthesis"], "types": ["T044"], "canonical_name": "paclitaxel biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. [GOC:jl, GOC:krc]"}
{"concept_id": "C1327036", "aliases": ["cocaine formation", "cocaine anabolism", "cocaine biosynthesis", "cocaine synthesis"], "types": ["T044"], "canonical_name": "cocaine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic. [GOC:ai]"}
{"concept_id": "C1327037", "aliases": ["acyl-CoA formation", "acyl-CoA synthesis", "acyl-CoA anabolism", "acyl-CoA biosynthesis"], "types": ["T044"], "canonical_name": "acyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. [GOC:cjk]"}
{"concept_id": "C1327038", "aliases": ["regulation of acyl-CoA synthesis", "regulation of acyl-CoA formation", "regulation of acyl-CoA biosynthesis", "regulation of acyl-CoA anabolism"], "types": ["T044"], "canonical_name": "regulation of acyl-CoA biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. [GOC:ai]"}
{"concept_id": "C1327039", "aliases": ["pyridoxal phosphate anabolism", "pyridoxal phosphate formation", "pyridoxal phosphate biosynthesis", "pyridoxal phosphate biosynthetic process", "pyridoxal phosphate synthesis", "active vitamin B6 biosynthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. [GOC:jl]", "canonical_name": "active vitamin B6 biosynthetic process"}
{"concept_id": "C1327040", "aliases": ["pyridoxal phosphate synthesis from pyridoxamine", "vitamin B6 biosynthesis from pyridoxamine", "pyridoxal phosphate anabolism from pyridoxamine", "pyridoxal 5'-phosphate salvage from pyridoxamine", "vitamin B6 biosynthetic process from pyridoxamine", "pyridoxal phosphate formation from pyridoxamine"], "types": ["T044"], "canonical_name": "pyridoxal phosphate biosynthetic process from pyridoxamine", "definition": "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine. [GOC:pz]"}
{"concept_id": "C1327041", "aliases": ["mycothiol synthesis", "mycothiol anabolism", "mycothiol biosynthesis", "mycothiol formation"], "types": ["T044"], "canonical_name": "mycothiol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione. [GOC:pz]"}
{"concept_id": "C1327042", "aliases": ["phytochromobilin synthesis", "phytochromobilin formation", "phytochromobilin biosynthesis", "phytochromobilin anabolism"], "types": ["T044"], "canonical_name": "phytochromobilin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha. [PMID:11402195]"}
{"concept_id": "C1327043", "aliases": ["achromobactin formation", "achromobactin anabolism", "achromobactin synthesis", "achromobactin biosynthesis"], "types": ["T044"], "canonical_name": "achromobactin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore. [GOC:jl, PMID:10928541]"}
{"concept_id": "C1327044", "aliases": ["chrysobactin synthesis", "chrysobactin biosynthesis", "chrysobactin formation", "chrysobactin anabolism"], "types": ["T044"], "canonical_name": "chrysobactin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). [GOC:jl, PMID:8837459]"}
{"concept_id": "C1327045", "aliases": ["pyochelin synthesis", "pyochelin anabolism", "pyochelin formation", "pyochelin biosynthesis"], "types": ["T044"], "canonical_name": "pyochelin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). [GOC:jl, PMID:6794030]"}
{"concept_id": "C1327048", "aliases": ["depsipeptide biosynthesis", "depsipeptide synthesis", "depsipeptide formation", "depsipeptide anabolism"], "types": ["T044"], "canonical_name": "depsipeptide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively. [GOC:go_curators]"}
{"concept_id": "C1327049", "aliases": ["4-amino-3-isothiazolidinone anabolism", "4-amino-3-isothiazolidinone biosynthesis", "4-amino-3-isothiazolidinone formation", "4-amino-3-isothiazolidinone synthesis"], "types": ["T044"], "canonical_name": "4-amino-3-isothiazolidinone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively. [GOC:jid]"}
{"concept_id": "C1327050", "aliases": ["poly(3-hydroxyalkanoate) synthesis", "poly(3-hydroxyalkanoate) anabolism", "poly(3-hydroxyalkanoate) formation", "poly(3-hydroxyalkanoate) biosynthesis"], "types": ["T044"], "canonical_name": "poly(3-hydroxyalkanoate) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. [GOC:jl, PMID:9925580]"}
{"concept_id": "C1327051", "aliases": ["regulation of hormone anabolism", "regulation of hormone biosynthesis", "regulation of hormone formation", "regulation of hormone synthesis"], "types": ["T044"], "canonical_name": "regulation of hormone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. [GOC:ai]"}
{"concept_id": "C1327052", "aliases": ["up regulation of hormone biosynthetic process", "positive regulation of hormone biosynthesis", "up-regulation of hormone biosynthetic process", "positive regulation of hormone synthesis", "positive regulation of hormone formation", "positive regulation of hormone anabolism", "upregulation of hormone biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of hormone biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. [GOC:ai]"}
{"concept_id": "C1327053", "aliases": ["ketone body biosynthesis", "ketone body synthesis", "ketone body formation", "ketone body anabolism"], "types": ["T044"], "canonical_name": "ketone body biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA. [ISBN:0198506732]"}
{"concept_id": "C1327054", "aliases": ["dhurrin biosynthesis", "dhurrin synthesis", "dhurrin formation", "dhurrin anabolism"], "types": ["T044"], "canonical_name": "dhurrin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound. [GOC:pz]"}
{"concept_id": "C1327055", "aliases": ["fructan biosynthesis", "fructan anabolism", "levan biosynthesis", "levan biosynthetic process", "fructan formation", "fructan synthesis"], "types": ["T044"], "canonical_name": "fructan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues. [GOC:pz]"}
{"concept_id": "C1327056", "aliases": ["amylopectin synthesis", "amylopectin formation", "amylopectin biosynthesis", "amylopectin anabolism"], "types": ["T044"], "canonical_name": "amylopectin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages. [ISBN:0943088399]"}
{"concept_id": "C1327057", "aliases": ["xyloglucan formation", "xyloglucan biosynthesis", "xyloglucan synthesis", "xyloglucan anabolism"], "types": ["T044"], "canonical_name": "xyloglucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of (1->4)-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants. [GOC:sm]"}
{"concept_id": "C1327058", "aliases": ["chondroitin sulfate proteoglycan synthesis", "chondroitin sulphate proteoglycan biosynthetic process", "chondroitin sulfate proteoglycan formation", "chondroitin sulphate proteoglycan biosynthesis", "chondroitin sulfate proteoglycan anabolism", "chondroitin sulfate proteoglycan biosynthesis"], "types": ["T044"], "canonical_name": "chondroitin sulfate proteoglycan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. [GOC:ai]"}
{"concept_id": "C1327059", "aliases": ["chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis", "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process", "chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis", "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis", "chondroitin sulfate proteoglycan formation, polysaccharide chain formation", "chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism", "chondroitin sulfate proteoglycan chain elongation"], "types": ["T044"], "canonical_name": "chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process", "definition": "The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate. [GOC:ai, PMID:11788602]"}
{"concept_id": "C1327060", "aliases": ["dermatan sulphate proteoglycan biosynthetic process", "dermatan sulphate proteoglycan biosynthesis", "dermatan sulfate proteoglycan biosynthesis", "chondroitin sulfate B proteoglycan biosynthetic process", "dermatan sulfate proteoglycan formation", "dermatan sulfate proteoglycan anabolism", "chondroitin sulfate B proteoglycan biosynthesis", "dermatan sulfate proteoglycan synthesis"], "types": ["T044"], "canonical_name": "dermatan sulfate proteoglycan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. [GOC:ai]"}
{"concept_id": "C1327061", "aliases": ["dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process", "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process", "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis", "dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis", "dermatan sulfate proteoglycan formation, polysaccharide chain formation", "dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism", "dermatan sulfate proteoglycan chain elongation", "dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis", "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis", "chondroitin sulfate B proteoglycan chain elongation"], "types": ["T044"], "canonical_name": "dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process", "definition": "The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate. [GOC:ai, PMID:11788602]"}
{"concept_id": "C1327062", "aliases": ["cutin formation", "cutin anabolism", "cutin biosynthesis", "cutin synthesis"], "types": ["T044"], "canonical_name": "cutin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants. [ISBN:0028623819]"}
{"concept_id": "C1327063", "aliases": ["long-chain fatty acid anabolism", "long-chain fatty acid synthesis", "long-chain fatty acid formation", "long-chain fatty acid biosynthesis"], "types": ["T044"], "canonical_name": "long-chain fatty acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22. [PMID:18390550]"}
{"concept_id": "C1327064", "aliases": ["very-long-chain fatty acid biosynthetic process", "very-long-chain fatty acid formation", "very-long-chain fatty acid biosynthesis", "very-long-chain fatty acid anabolism", "very-long-chain fatty acid synthesis"], "types": ["T044"], "canonical_name": "very long-chain fatty acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22. [PMID:7744868]"}
{"concept_id": "C1327065", "aliases": ["wax synthesis", "wax anabolism", "wax formation", "wax biosynthesis"], "types": ["T044"], "canonical_name": "wax biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids. [ISBN:0943088399]"}
{"concept_id": "C1327066", "aliases": ["DPP biosynthesis", "dimethylallyl diphosphate biosynthesis", "dimethylallyl diphosphate anabolism", "dimethylallyl diphosphate formation", "dimethylallyl diphosphate synthesis", "dimethylallyl pyrophosphate biosynthesis", "dimethylallyl pyrophosphate biosynthetic process", "DPP biosynthetic process"], "types": ["T044"], "canonical_name": "dimethylallyl diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate. [GOC:ai]"}
{"concept_id": "C1327068", "aliases": ["regulation of abscisic acid biosynthesis", "regulation of abscisic acid synthesis", "regulation of abscisic acid formation", "regulation of abscisic acid anabolism"], "types": ["T044"], "canonical_name": "regulation of abscisic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. [GOC:sm]"}
{"concept_id": "C1327069", "aliases": ["positive regulation of abscisic acid synthesis", "up-regulation of abscisic acid biosynthetic process", "positive regulation of abscisic acid biosynthesis", "upregulation of abscisic acid biosynthetic process", "positive regulation of abscisic acid anabolism", "up regulation of abscisic acid biosynthetic process", "positive regulation of abscisic acid formation"], "types": ["T044"], "canonical_name": "positive regulation of abscisic acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. [GOC:sm]"}
{"concept_id": "C1327070", "aliases": ["dolichyl monophosphate formation", "dolichyl monophosphate anabolism", "dolichyl monophosphate biosynthesis", "dolichyl monophosphate synthesis"], "types": ["T044"], "canonical_name": "dolichyl monophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative. [GOC:jl]"}
{"concept_id": "C1327071", "aliases": ["GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine", "GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine", "GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine"], "types": ["T044"], "canonical_name": "GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. [RESID:AA0165]"}
{"concept_id": "C1327072", "aliases": ["GPI anchor formation via N-threonyl-glycosylphosphatidylinositolethanolamine", "GPI anchor anabolism via N-threonyl-glycosylphosphatidylinositolethanolamine", "GPI anchor synthesis via N-threonyl-glycosylphosphatidylinositolethanolamine"], "types": ["T044"], "canonical_name": "GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. [RESID:AA0164]"}
{"concept_id": "C1327073", "aliases": ["regulation of lipid biosynthesis", "regulation of lipid synthesis", "regulation of lipid formation", "regulation of lipid anabolism", "regulation of lipogenesis"], "types": ["T044"], "canonical_name": "regulation of lipid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. [GOC:ai]"}
{"concept_id": "C1327074", "aliases": ["up regulation of lipid biosynthetic process", "upregulation of lipid biosynthetic process", "positive regulation of lipid biosynthesis", "positive regulation of lipid synthesis", "positive regulation of lipid formation", "positive regulation of lipid biosynthetic process", "up-regulation of lipid biosynthetic process", "positive regulation of lipogenesis"], "types": ["T044"], "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. [GOC:ai]", "canonical_name": "positive regulation of lipid anabolism"}
{"concept_id": "C1327075", "aliases": ["regulation of steroid formation", "regulation of steroidogenesis", "regulation of steroid anabolism", "regulation of steroid biosynthesis", "regulation of steroid synthesis"], "types": ["T044"], "canonical_name": "regulation of steroid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [GOC:ai]"}
{"concept_id": "C1327085", "aliases": ["3'-phosphoadenylyl-sulfate biosynthetic process", "3'-phosphoadenosine 5'-phosphosulfate biosynthesis", "phosphoadenosine phosphosulfate biosynthesis", "phosphoadenosine phosphosulfate biosynthetic process", "3'-phosphoadenosine 5'-phosphosulfate synthesis", "3'-phosphoadenosine 5'-phosphosulphate biosynthesis", "PAPS biosynthesis", "3'-phosphoadenosine 5'-phosphosulfate anabolism", "3'-phosphoadenosine 5'-phosphosulfate formation", "PAPS biosynthetic process", "3'-phosphoadenylyl-sulfate biosynthesis", "adenosine 3'-phosphate 5'-phosphosulfate biosynthetic process", "3'-phosphoadenosine 5'-phosphosulphate biosynthetic process", "adenosine 3'-phosphate 5'-phosphosulfate biosynthesis"], "types": ["T044"], "canonical_name": "3'-phosphoadenosine 5'-phosphosulfate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [ISBN:0198506732]"}
{"concept_id": "C1327086", "aliases": ["regulation of nucleotide anabolism", "regulation of nucleotide biosynthesis", "regulation of nucleotide synthesis", "regulation of nucleotide formation"], "types": ["T044"], "canonical_name": "regulation of nucleotide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. [GOC:mah]"}
{"concept_id": "C1327087", "aliases": ["negative regulation of nucleotide biosynthesis", "downregulation of nucleotide biosynthetic process", "down-regulation of nucleotide biosynthetic process", "negative regulation of nucleotide synthesis", "negative regulation of nucleotide anabolism", "down regulation of nucleotide biosynthetic process", "negative regulation of nucleotide formation"], "types": ["T044"], "canonical_name": "negative regulation of nucleotide biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. [GOC:mah]"}
{"concept_id": "C1327088", "aliases": ["up-regulation of nucleotide biosynthetic process", "positive regulation of nucleotide formation", "upregulation of nucleotide biosynthetic process", "up regulation of nucleotide biosynthetic process", "positive regulation of nucleotide biosynthesis", "positive regulation of nucleotide synthesis", "positive regulation of nucleotide anabolism"], "types": ["T044"], "canonical_name": "positive regulation of nucleotide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. [GOC:mah]"}
{"concept_id": "C1327090", "aliases": ["biotin carboxyl carrier protein anabolism", "BCCP biosynthetic process", "biotin carboxyl carrier protein biosynthesis", "biotin carboxyl carrier protein formation", "BCCP biosynthesis", "biotin carboxyl carrier protein synthesis"], "types": ["T044"], "canonical_name": "biotin carboxyl carrier protein biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase. [GOC:go_curators, PMID:8102363]"}
{"concept_id": "C1327111", "aliases": ["amyloid precursor protein formation", "APP biosynthetic process", "amyloid precursor protein biosynthesis", "APP biosynthesis", "amyloid precursor protein anabolism", "amyloid precursor protein synthesis"], "types": ["T044"], "canonical_name": "amyloid precursor protein biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators]"}
{"concept_id": "C1327112", "aliases": ["regulation of amyloid precursor protein formation", "regulation of amyloid precursor protein synthesis", "regulation of amyloid precursor protein biosynthesis", "regulation of APP biosynthetic process", "regulation of amyloid precursor protein anabolism", "regulation of APP biosynthesis"], "types": ["T044"], "canonical_name": "regulation of amyloid precursor protein biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. [GOC:go_curators]"}
{"concept_id": "C1327113", "aliases": ["negative regulation of amyloid precursor protein anabolism", "down-regulation of amyloid precursor protein biosynthetic process", "negative regulation of amyloid precursor protein formation", "downregulation of amyloid precursor protein biosynthetic process", "negative regulation of amyloid precursor protein synthesis", "negative regulation of amyloid precursor protein biosynthesis", "negative regulation of APP biosynthetic process", "down regulation of amyloid precursor protein biosynthetic process", "negative regulation of APP biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of amyloid precursor protein biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. [GOC:go_curators]"}
{"concept_id": "C1327114", "aliases": ["positive regulation of APP biosynthetic process", "positive regulation of amyloid precursor protein formation", "up regulation of amyloid precursor protein biosynthetic process", "positive regulation of amyloid precursor protein synthesis", "upregulation of amyloid precursor protein biosynthetic process", "positive regulation of amyloid precursor protein anabolism", "positive regulation of APP biosynthesis", "up-regulation of amyloid precursor protein biosynthetic process", "positive regulation of amyloid precursor protein biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of amyloid precursor protein biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. [GOC:go_curators]"}
{"concept_id": "C1327115", "aliases": ["regulation of hemoglobin formation", "regulation of hemoglobin anabolism", "regulation of haemoglobin biosynthetic process", "regulation of hemoglobin biosynthesis", "regulation of hemoglobin synthesis", "regulation of haemoglobin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of hemoglobin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:ai]"}
{"concept_id": "C1327116", "aliases": ["downregulation of hemoglobin biosynthetic process", "negative regulation of hemoglobin biosynthesis", "negative regulation of hemoglobin synthesis", "down regulation of hemoglobin biosynthetic process", "negative regulation of haemoglobin biosynthetic process", "negative regulation of hemoglobin anabolism", "down-regulation of hemoglobin biosynthetic process", "negative regulation of hemoglobin formation", "negative regulation of haemoglobin biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of hemoglobin biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:ai]"}
{"concept_id": "C1327117", "aliases": ["up-regulation of hemoglobin biosynthetic process", "positive regulation of hemoglobin formation", "positive regulation of haemoglobin biosynthesis", "positive regulation of haemoglobin biosynthetic process", "upregulation of hemoglobin biosynthetic process", "positive regulation of hemoglobin biosynthesis", "up regulation of hemoglobin biosynthetic process", "positive regulation of hemoglobin anabolism", "positive regulation of hemoglobin synthesis"], "types": ["T044"], "canonical_name": "positive regulation of hemoglobin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:ai]"}
{"concept_id": "C1327118", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glycine N-palmitoylation", "definition": "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine. [RESID:AA0339]"}
{"concept_id": "C1327127", "aliases": ["miRNA biosynthetic process", "miRNA biogenesis", "microRNA biogenesis", "production of microRNAs involved in gene silencing by microRNA", "miRNA-mediated gene silencing, production of miRNAs", "microRNA processing", "miRNA processing", "production of miRNAs involved in gene silencing by miRNA", "microRNA-mediated gene silencing, production of microRNAs", "miRNA maturation", "gene silencing by miRNA, production of miRNAs", "microRNA biosynthetic process"], "types": ["T045"], "definition": "A process that begins with the synthesis of a pri-miRNA from a DNA template by RNA Polymerase II, which is then enzymatically processed to produce a pre-miRNA intermediate by the microprocessor complex, and ends with the release of the mature miRNA from the pre-miRNA catalyzed by the enzyme Dicer.", "canonical_name": "microRNA biosynthesis"}
{"concept_id": "C1327128", "aliases": ["D-galactarate anabolism", "D-galactarate biosynthetic process", "D-galactarate synthesis", "D-galactarate formation"], "types": ["T044"], "canonical_name": "D-galactarate biosynthesis"}
{"concept_id": "C1327129", "aliases": ["saccharate biosynthetic process", "saccharate biosynthesis", "D-glucarate biosynthesis", "D-glucarate synthesis", "D-glucarate anabolism", "D-glucarate formation"], "types": ["T044"], "canonical_name": "D-glucarate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate. [GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1327130", "aliases": ["poly-hydroxybutyrate formation", "PHB biosynthetic process", "poly-hydroxybutyrate biosynthesis", "poly-hydroxybutyrate synthesis", "PHB biosynthesis", "poly-hydroxybutyrate anabolism"], "types": ["T044"], "canonical_name": "poly-hydroxybutyrate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells. [GOC:jl, PMID:18640095]"}
{"concept_id": "C1327131", "aliases": ["D-glucuronate biosynthesis", "D-glucuronate formation", "D-glucuronate synthesis", "D-glucuronate anabolism"], "types": ["T044"], "canonical_name": "D-glucuronate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C1327132", "aliases": ["quinolinate biosynthesis", "quinolinate formation", "quinolinate anabolism", "quinolinate synthesis"], "types": ["T044"], "canonical_name": "quinolinate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. [GOC:ai]"}
{"concept_id": "C1327133", "aliases": ["peptide biosynthetic process", "peptide biosynthesis", "peptide synthesis", "peptide anabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. [GOC:dph, GOC:jl]", "canonical_name": "peptide formation"}
{"concept_id": "C1327134", "aliases": ["pheromone anabolism", "pheromone formation", "pheromone synthesis", "pheromone biosynthesis"], "types": ["T044"], "canonical_name": "pheromone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. [ISBN:0198506732]"}
{"concept_id": "C1327135", "aliases": ["tocopherol biosynthesis", "tocopherol biosynthetic process", "vitamin E synthesis", "vitamin E anabolism", "vitamin E biosynthesis", "vitamin E formation"], "types": ["T044"], "canonical_name": "vitamin E biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. [GOC:mg]"}
{"concept_id": "C1327136", "aliases": ["vitamin B6 biosynthesis", "vitamin B6 biosynthetic process", "vitamin B6 synthesis", "vitamin B6 formation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]", "canonical_name": "vitamin B6 anabolism"}
{"concept_id": "C1327137", "aliases": ["pyridoxal formation", "pyridoxal anabolism", "pyridoxal synthesis", "pyridoxal biosynthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. [GOC:jl, http://www.mblab.gla.ac.uk/]", "canonical_name": "pyridoxal biosynthetic process"}
{"concept_id": "C1327139", "aliases": ["levan catabolic process", "fructan degradation", "levan catabolism", "fructan catabolism", "fructan breakdown"], "types": ["T044"], "canonical_name": "fructan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues. [GOC:pz]"}
{"concept_id": "C1327140", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate phosphorylation", "definition": "The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. [ISBN:0198506732]"}
{"concept_id": "C1327141", "aliases": [], "types": ["T044"], "canonical_name": "inositol and derivative phosphorylation"}
{"concept_id": "C1327142", "aliases": [], "types": ["T044"], "canonical_name": "phosphorylated carbohydrate dephosphorylation", "definition": "The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it. [ISBN:0198506732]"}
{"concept_id": "C1327143", "aliases": [], "types": ["T044"], "canonical_name": "inositol phosphate dephosphorylation", "definition": "The process of removing a phosphate group from any mono- or polyphosphorylated inositol. [ISBN:0198506732]"}
{"concept_id": "C1327144", "aliases": ["levan metabolic process", "fructan metabolism"], "types": ["T044"], "canonical_name": "fructan metabolic process", "definition": "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues. [GOC:sm]"}
{"concept_id": "C1327145", "aliases": ["chondroitin sulphate proteoglycan metabolic process", "chondroitin sulfate proteoglycan metabolism", "chondroitin sulphate proteoglycan metabolism"], "types": ["T044"], "canonical_name": "chondroitin sulfate proteoglycan metabolic process", "definition": "The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. [GOC:ai]"}
{"concept_id": "C1327146", "aliases": ["chondroitin sulfate B proteoglycan metabolism", "dermatan sulphate proteoglycan metabolic process", "dermatan sulphate proteoglycan metabolism", "chondroitin sulfate B proteoglycan metabolic process", "dermatan sulfate proteoglycan metabolism"], "types": ["T044"], "canonical_name": "dermatan sulfate proteoglycan metabolic process", "definition": "The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. [GOC:ai]"}
{"concept_id": "C1327147", "aliases": ["endogenous antibiotic catabolism", "endogenous antibiotic degradation", "endogenous antibiotic breakdown"], "types": ["T044"], "canonical_name": "endogenous antibiotic catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism. [GOC:jl]"}
{"concept_id": "C1327148", "aliases": ["exogenous antibiotic breakdown", "exogenous antibiotic degradation", "exogenous antibiotic catabolism"], "types": ["T044"], "canonical_name": "exogenous antibiotic catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism. [GOC:jl]"}
{"concept_id": "C1327149", "aliases": ["achromobactin catabolism", "achromobactin breakdown", "achromobactin degradation"], "types": ["T044"], "canonical_name": "achromobactin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore. [GOC:jl, PMID:10928541]"}
{"concept_id": "C1327150", "aliases": ["chrysobactin breakdown", "chrysobactin degradation", "chrysobactin catabolism"], "types": ["T044"], "canonical_name": "chrysobactin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). [GOC:jl, PMID:8837459]"}
{"concept_id": "C1327151", "aliases": ["pyochelin breakdown", "pyochelin degradation", "pyochelin catabolism"], "types": ["T044"], "canonical_name": "pyochelin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). [GOC:jl, PMID:6794030]"}
{"concept_id": "C1327152", "aliases": ["depsipeptide breakdown", "depsipeptide degradation", "depsipeptide catabolism"], "types": ["T044"], "canonical_name": "depsipeptide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively. [GOC:go_curators]"}
{"concept_id": "C1327153", "aliases": ["assembly of extrachromosomal circular DNA"], "types": ["T045"], "canonical_name": "formation of extrachromosomal circular DNA", "definition": "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats. [GOC:jh, PMID:12044938]"}
{"concept_id": "C1327155", "aliases": ["cocaine catabolism", "cocaine breakdown", "cocaine degradation"], "types": ["T044"], "canonical_name": "cocaine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic. [ISBN:0198506732]"}
{"concept_id": "C1327158", "aliases": ["ketone body catabolism", "ketone body degradation", "ketolysis", "ketone body breakdown", "utilization of ketone bodies"], "types": ["T044"], "canonical_name": "ketone body catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA. [ISBN:0198506732]"}
{"concept_id": "C1327159", "aliases": ["long-chain fatty acid breakdown", "long-chain fatty acid catabolism", "long-chain fatty acid degradation"], "types": ["T044"], "canonical_name": "long-chain fatty acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22. [PMID:20043225]"}
{"concept_id": "C1327160", "aliases": ["very-long-chain fatty acid catabolic process", "very-long-chain fatty acid catabolism", "very-long-chain fatty acid degradation", "very-long-chain fatty acid breakdown"], "types": ["T044"], "canonical_name": "very long-chain fatty acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22. [PMID:7744868]"}
{"concept_id": "C1327161", "aliases": ["amyloid precursor protein degradation", "APP catabolism", "amyloid precursor protein breakdown", "APP catabolic process", "amyloid precursor protein catabolism"], "types": ["T044"], "canonical_name": "amyloid precursor protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators]"}
{"concept_id": "C1327164", "aliases": [], "types": ["T044"], "canonical_name": "cytidine deamination", "definition": "The removal of amino group in the presence of water. [GOC:sm]"}
{"concept_id": "C1327171", "aliases": ["regulation of cyclic nucleotide degradation", "regulation of cyclic nucleotide catabolism", "regulation of cyclic nucleotide breakdown"], "types": ["T044"], "canonical_name": "regulation of cyclic nucleotide catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides. [GOC:mah]"}
{"concept_id": "C1327174", "aliases": ["regulation of nucleotide breakdown", "regulation of nucleotide catabolism", "regulation of nucleotide degradation"], "types": ["T044"], "canonical_name": "regulation of nucleotide catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. [GOC:mah]"}
{"concept_id": "C1327175", "aliases": ["negative regulation of nucleotide breakdown", "down-regulation of nucleotide catabolic process", "negative regulation of nucleotide degradation", "down regulation of nucleotide catabolic process", "downregulation of nucleotide catabolic process", "negative regulation of nucleotide catabolism"], "types": ["T044"], "canonical_name": "negative regulation of nucleotide catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. [GOC:mah]"}
{"concept_id": "C1327176", "aliases": ["positive regulation of nucleotide degradation", "positive regulation of nucleotide catabolism", "up-regulation of nucleotide catabolic process", "up regulation of nucleotide catabolic process", "positive regulation of nucleotide breakdown", "upregulation of nucleotide catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of nucleotide catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. [GOC:mah]"}
{"concept_id": "C1327177", "aliases": ["initiation of acetate catabolism", "initiation of acetate breakdown", "initiation of acetate degradation"], "types": ["T044"], "canonical_name": "initiation of acetate catabolic process", "definition": "The activation of the chemical reactions and pathways resulting in the breakdown of acetate. [GOC:jl]"}
{"concept_id": "C1327178", "aliases": ["saccharate catabolism", "saccharate catabolic process", "D-glucarate catabolism", "D-glucarate degradation", "D-glucarate breakdown"], "types": ["T044"], "canonical_name": "D-glucarate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate. [GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1327179", "aliases": ["D-glucuronate breakdown", "D-glucuronate degradation", "D-glucuronate catabolism"], "types": ["T044"], "canonical_name": "D-glucuronate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C1327180", "aliases": ["pheromone catabolism", "pheromone degradation", "pheromone breakdown", "pheromone catabolic process"], "types": ["T040"], "canonical_name": "pheromone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. [ISBN:0198506732]"}
{"concept_id": "C1327181", "aliases": ["vitamin B6 catabolism", "vitamin B6 breakdown", "vitamin B6 degradation"], "types": ["T044"], "canonical_name": "vitamin B6 catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]"}
{"concept_id": "C1327182", "aliases": ["trichloroethylene degradation", "trichloroethylene breakdown", "trichloroethylene catabolism", "trichloroethene catabolism", "trichloroethene catabolic process"], "types": ["T044"], "canonical_name": "trichloroethylene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent. [GOC:ai]"}
{"concept_id": "C1327183", "aliases": ["active vitamin B6 metabolism", "pyridoxal phosphate metabolic process", "active vitamin B6 metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. [GOC:jl]", "canonical_name": "pyridoxal phosphate metabolism"}
{"concept_id": "C1327184", "aliases": ["mycothiol metabolism"], "types": ["T044"], "canonical_name": "mycothiol metabolic process", "definition": "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione. [GOC:pz]"}
{"concept_id": "C1327185", "aliases": ["achromobactin metabolism"], "types": ["T044"], "canonical_name": "achromobactin metabolic process", "definition": "The chemical reactions and pathways involving achromobactin, a citrate siderophore. [GOC:jl, PMID:10928541]"}
{"concept_id": "C1327186", "aliases": ["chrysobactin metabolism"], "types": ["T044"], "canonical_name": "chrysobactin metabolic process", "definition": "The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). [GOC:jl, PMID:8837459]"}
{"concept_id": "C1327187", "aliases": ["pyochelin metabolism"], "types": ["T044"], "canonical_name": "pyochelin metabolic process", "definition": "The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). [GOC:jl, PMID:6794030]"}
{"concept_id": "C1327188", "aliases": ["depsipeptide metabolism"], "types": ["T044"], "canonical_name": "depsipeptide metabolic process", "definition": "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively. [GOC:go_curators]"}
{"concept_id": "C1327189", "aliases": ["cocaine metabolism"], "types": ["T044"], "canonical_name": "cocaine metabolic process", "definition": "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic. [ISBN:0198506732]"}
{"concept_id": "C1327190", "aliases": [], "types": ["T044"], "canonical_name": "ATP synthesis coupled electron transport", "definition": "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. [ISBN:0716731363]"}
{"concept_id": "C1327191", "aliases": [], "types": ["T044"], "canonical_name": "plasma membrane ATP synthesis coupled electron transport", "definition": "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane. [GOC:mtg_sensu, ISBN:0716731363]"}
{"concept_id": "C1327192", "aliases": [], "types": ["T044"], "canonical_name": "organelle ATP synthesis coupled electron transport"}
{"concept_id": "C1327193", "aliases": [], "types": ["T044"], "canonical_name": "complex IV (reduction of O2)"}
{"concept_id": "C1327194", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial electron transport, ubiquinol to cytochrome c", "definition": "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. [ISBN:0716731363]"}
{"concept_id": "C1327195", "aliases": ["acetate fermentation to butyrate, ethanol, acetone and butanol"], "types": ["T044"], "canonical_name": "acetate catabolic process to butyrate, ethanol, acetone and butanol", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol. [GOC:pz]"}
{"concept_id": "C1327196", "aliases": ["paclitaxel metabolism"], "types": ["T044"], "canonical_name": "paclitaxel metabolic process", "definition": "The chemical reactions and pathways involving paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. [GOC:jl, GOC:krc]"}
{"concept_id": "C1327197", "aliases": ["poly(3-hydroxyalkanoate) metabolism"], "types": ["T044"], "canonical_name": "poly(3-hydroxyalkanoate) metabolic process", "definition": "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. [GOC:jl, PMID:9925580]"}
{"concept_id": "C1327198", "aliases": ["vitamin A1 acid metabolism", "vitamin A1 acid metabolic process", "retinoic acid metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]", "canonical_name": "retinoic acid metabolism"}
{"concept_id": "C1327199", "aliases": ["9-cis-retinoic acid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative. [GOC:jl, PMID:11279029]", "canonical_name": "9-cis-retinoic acid metabolic process"}
{"concept_id": "C1327200", "aliases": ["9-cis-retinoic acid formation", "9-cis-retinoic acid biosynthetic process", "9-cis-retinoic acid synthesis", "9-cis-retinoic acid anabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative. [GOC:jl, PMID:11279029]", "canonical_name": "9-cis-retinoic acid biosynthesis"}
{"concept_id": "C1327201", "aliases": ["vitamin A1 metabolism", "vitamin A1 alcohol metabolic process", "vitamin A1 metabolic process", "vitamin A1 alcohol metabolism", "retinol metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]", "canonical_name": "retinol metabolism"}
{"concept_id": "C1327202", "aliases": ["cellular ketone body metabolism"], "types": ["T044"], "canonical_name": "cellular ketone body metabolic process", "definition": "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism. [ISBN:0198506732]"}
{"concept_id": "C1327203", "aliases": ["lauric acid metabolism", "n-dodecanoic acid metabolism", "n-dodecanoic acid metabolic process"], "types": ["T044"], "canonical_name": "lauric acid metabolic process", "definition": "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources. [GOC:jid, PMID:15555597]"}
{"concept_id": "C1327204", "aliases": ["wax metabolism"], "types": ["T044"], "canonical_name": "wax metabolic process", "definition": "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids. [GOC:sm]"}
{"concept_id": "C1327205", "aliases": ["dimethylallyl pyrophosphate metabolic process", "DPP metabolic process", "dimethylallyl diphosphate metabolism", "DPP metabolism", "dimethylallyl pyrophosphate metabolism"], "types": ["T044"], "canonical_name": "dimethylallyl diphosphate metabolic process", "definition": "The chemical reactions and pathways involving dimethylallyl diphosphate. [GOC:ai]"}
{"concept_id": "C1327206", "aliases": [], "types": ["T044"], "canonical_name": "xanthophyll cycle", "definition": "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II. [ISBN:0122146743]"}
{"concept_id": "C1327207", "aliases": [], "types": ["T044"], "canonical_name": "lipid phosphorylation", "definition": "The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. [GOC:bf, ISBN:0198506732]"}
{"concept_id": "C1327209", "aliases": [], "types": ["T044"], "canonical_name": "phospholipid dephosphorylation", "definition": "The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. [ISBN:0198506732]"}
{"concept_id": "C1327210", "aliases": ["phosphoinositide dephosphorylation"], "types": ["T044"], "canonical_name": "phosphatidylinositol dephosphorylation", "definition": "The process of removing one or more phosphate groups from a phosphatidylinositol. [ISBN:0198506732]"}
{"concept_id": "C1327211", "aliases": ["sequestration of triacylglycerol", "triglyceride retention", "triglyceride sequestration", "storage of triglyceride", "sequestration of triglyceride", "triglyceride storage", "sequestering of triacylglycerol", "triacylglycerol sequestering", "triacylglycerol storage", "triacylglycerol sequestration", "retention of triglyceride", "triacylglycerol retention", "retention of triacylglycerol", "storage of triacylglycerol", "triglyceride sequestering"], "types": ["T043"], "canonical_name": "sequestering of triglyceride", "definition": "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1327214", "aliases": [], "types": ["T044"], "canonical_name": "purine deoxyribonucleoside salvage", "definition": "Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1327215", "aliases": [], "types": ["T044"], "canonical_name": "purine ribonucleoside salvage", "definition": "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1327216", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleotide salvage", "definition": "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis. [GOC:pz]"}
{"concept_id": "C1327217", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine nucleoside salvage", "definition": "Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1327218", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside salvage", "definition": "Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1327219", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine ribonucleotide salvage", "definition": "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis. [GOC:pz]"}
{"concept_id": "C1327220", "aliases": ["epothilone metabolism"], "types": ["T044"], "canonical_name": "epothilone metabolic process", "definition": "The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer. [ISBN:0198506732]"}
{"concept_id": "C1327221", "aliases": ["nitrile metabolism"], "types": ["T044"], "canonical_name": "nitrile metabolic process", "definition": "The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile. [PMID:18987211]"}
{"concept_id": "C1327222", "aliases": ["nitrile breakdown", "nitrile catabolism", "nitrile degradation"], "types": ["T044"], "canonical_name": "nitrile catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom. [ISBN:0721662544]"}
{"concept_id": "C1327223", "aliases": ["ureide metabolism"], "types": ["T044"], "canonical_name": "ureide metabolic process", "definition": "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants. [GOC:pz]"}
{"concept_id": "C1327224", "aliases": ["ureide anabolism", "ureide synthesis", "ureide formation", "ureide biosynthesis"], "types": ["T044"], "canonical_name": "ureide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots. [GOC:pz]"}
{"concept_id": "C1327225", "aliases": ["ureide degradation", "ureide catabolism", "ureide breakdown"], "types": ["T044"], "canonical_name": "ureide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium. [GOC:pz]"}
{"concept_id": "C1327235", "aliases": ["3'-phosphoadenosine 5'-phosphosulphate metabolism", "phosphoadenosine phosphosulfate metabolic process", "3'-phosphoadenylyl-sulfate metabolic process", "adenosine 3'-phosphate 5'-phosphosulfate metabolic process", "3'-phosphoadenylyl-sulfate metabolism", "3'-phosphoadenosine 5'-phosphosulphate metabolic process", "3'-phosphoadenosine 5'-phosphosulfate metabolism", "phosphoadenosine phosphosulfate metabolism", "PAPS metabolic process", "PAPS metabolism", "adenosine 3'-phosphate 5'-phosphosulfate metabolism"], "types": ["T044"], "canonical_name": "3'-phosphoadenosine 5'-phosphosulfate metabolic process", "definition": "The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [ISBN:0198506732]"}
{"concept_id": "C1327236", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside monophosphate phosphorylation", "definition": "The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside. [GOC:ai]"}
{"concept_id": "C1327237", "aliases": [], "types": ["T044"], "canonical_name": "nucleotide phosphorylation", "definition": "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. [GOC:ai]"}
{"concept_id": "C1327238", "aliases": ["small nucleolar RNA localization", "snoRNA localisation", "establishment and maintenance of snoRNA localization"], "types": ["T043"], "canonical_name": "snoRNA localization", "definition": "Any process in which small nucleolar RNA is transported to, or maintained in, a specific location. [ISBN:0716731363]"}
{"concept_id": "C1327239", "aliases": ["antisense RNA metabolism"], "types": ["T045"], "canonical_name": "antisense RNA metabolic process", "definition": "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis. [GOC:jl]"}
{"concept_id": "C1327240", "aliases": [], "types": ["T045"], "canonical_name": "microRNA metabolism"}
{"concept_id": "C1327242", "aliases": ["alternative mRNA splicing, via spliceosome", "alternative nuclear mRNA splicing, via spliceosome"], "types": ["T045"], "definition": "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. [GOC:krc, PMID:12110900]", "canonical_name": "splice site selection"}
{"concept_id": "C1327243", "aliases": ["intergenic nuclear mRNA trans splicing"], "types": ["T045"], "canonical_name": "intergenic mRNA trans splicing", "definition": "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing. [GOC:krc, PMID:11726664, PMID:12110900]"}
{"concept_id": "C1327244", "aliases": ["splice site selection", "regulation of alternative nuclear mRNA splicing, via spliceosome"], "types": ["T045"], "definition": "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. [GOC:krc]", "canonical_name": "regulation of alternative mRNA splicing, via spliceosome"}
{"concept_id": "C1327245", "aliases": ["spliceosomal tri-snRNP U4atac/U6atac.U5 assembly"], "types": ["T045"], "canonical_name": "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5"}
{"concept_id": "C1327246", "aliases": [], "types": ["T045"], "canonical_name": "cis assembly of U12-type pre-catalytic spliceosome"}
{"concept_id": "C1327247", "aliases": [], "types": ["T045"], "canonical_name": "formation of catalytic U12-type spliceosome for second transesterification step"}
{"concept_id": "C1327248", "aliases": [], "types": ["T045"], "canonical_name": "U12-type catalytic spliceosome formation for first transesterification step"}
{"concept_id": "C1327249", "aliases": [], "types": ["T045"], "canonical_name": "U12-type nuclear mRNA 3'-splice site recognition"}
{"concept_id": "C1327250", "aliases": ["U12-type nuclear mRNA 5'-splice site recognition"], "types": ["T045"], "canonical_name": "U12-type nuclear mRNA 5' splice site recognition"}
{"concept_id": "C1327251", "aliases": [], "types": ["T045"], "canonical_name": "U12-type nuclear mRNA branch site recognition"}
{"concept_id": "C1327252", "aliases": [], "types": ["T045"], "canonical_name": "U12-type spliceosome conformational change to release U4atac and U11"}
{"concept_id": "C1327254", "aliases": ["spliceosomal tri-snRNP U4/U6.U5 assembly"], "types": ["T045"], "canonical_name": "assembly of spliceosomal tri-snRNP U4/U6.U5"}
{"concept_id": "C1327255", "aliases": [], "types": ["T045"], "canonical_name": "formation of catalytic U2-type spliceosome for second transesterification step"}
{"concept_id": "C1327257", "aliases": [], "types": ["T045"], "canonical_name": "cis assembly of U2-type pre-catalytic spliceosome"}
{"concept_id": "C1327258", "aliases": ["U2-type nuclear mRNA 5'-splice site recognition"], "types": ["T045"], "canonical_name": "U2-type nuclear mRNA 5' splice site recognition"}
{"concept_id": "C1327259", "aliases": [], "types": ["T045"], "canonical_name": "nuclear mRNA trans splicing, via U2-type spliceosome"}
{"concept_id": "C1327260", "aliases": ["nuclear mRNA trans splicing, SL addition", "nuclear mRNA trans splicing, spliced leader addition"], "types": ["T045"], "canonical_name": "mRNA trans splicing, SL addition", "definition": "The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body. [GOC:krc, ISBN:0879695897, PMID:2675423]"}
{"concept_id": "C1327261", "aliases": [], "types": ["T045"], "canonical_name": "formation of quadruple SL/U4/U5/U6 snRNP", "definition": "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA. [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1327262", "aliases": ["trans assembly of spliced leader-containing precatalytic spliceosome"], "types": ["T045"], "canonical_name": "trans assembly of SL-containing precatalytic spliceosome", "definition": "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA. [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]"}
{"concept_id": "C1327263", "aliases": [], "types": ["T045"], "canonical_name": "regulation of nuclear mRNA splicing via U2-type spliceosome"}
{"concept_id": "C1327264", "aliases": ["down-regulation of nuclear mRNA splicing via U2-type spliceosome", "down regulation of nuclear mRNA splicing via U2-type spliceosome", "downregulation of nuclear mRNA splicing via U2-type spliceosome"], "types": ["T045"], "canonical_name": "negative regulation of nuclear mRNA splicing via U2-type spliceosome"}
{"concept_id": "C1327265", "aliases": ["up-regulation of nuclear mRNA splicing via U2-type spliceosome", "up regulation of nuclear mRNA splicing via U2-type spliceosome", "upregulation of nuclear mRNA splicing via U2-type spliceosome"], "types": ["T045"], "canonical_name": "positive regulation of nuclear mRNA splicing via U2-type spliceosome"}
{"concept_id": "C1327266", "aliases": [], "types": ["T045"], "canonical_name": "U2-type catalytic spliceosome formation for first transesterification step"}
{"concept_id": "C1327267", "aliases": [], "types": ["T045"], "canonical_name": "U2-type nuclear mRNA 3'-splice site recognition"}
{"concept_id": "C1327268", "aliases": [], "types": ["T045"], "canonical_name": "U2-type nuclear mRNA branch site recognition"}
{"concept_id": "C1327271", "aliases": [], "types": ["T045"], "canonical_name": "regulation of pre-mRNA splicing"}
{"concept_id": "C1327272", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of pre-mRNA splicing"}
{"concept_id": "C1327273", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of pre-mRNA splicing"}
{"concept_id": "C1327274", "aliases": [], "types": ["T045"], "canonical_name": "spliceosomal conformational changes to generate catalytic conformation", "definition": "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. [GOC:krc]"}
{"concept_id": "C1327275", "aliases": ["formation of catalytic spliceosome for first transesterification step"], "types": ["T045"], "canonical_name": "generation of catalytic spliceosome for first transesterification step", "definition": "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1327276", "aliases": ["formation of catalytic spliceosome for second transesterification step"], "types": ["T045"], "canonical_name": "generation of catalytic spliceosome for second transesterification step", "definition": "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1327277", "aliases": [], "types": ["T045"], "canonical_name": "spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)", "definition": "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11). [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1327278", "aliases": [], "types": ["T045"], "canonical_name": "spliceosomal snRNP biogenesis"}
{"concept_id": "C1327279", "aliases": [], "types": ["T045"], "canonical_name": "cis assembly of pre-catalytic spliceosome", "definition": "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner. [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]"}
{"concept_id": "C1327280", "aliases": ["nuclear mRNA 3'-splice site recognition"], "types": ["T045"], "canonical_name": "mRNA 3'-splice site recognition", "definition": "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome. [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1327281", "aliases": ["nuclear mRNA 5'-splice site recognition", "nuclear mRNA 5' splice site recognition"], "types": ["T045"], "canonical_name": "mRNA 5'-splice site recognition", "definition": "Recognition of the intron 5'-splice site by components of the assembling spliceosome. [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1327282", "aliases": ["nuclear mRNA branch site recognition"], "types": ["T045"], "canonical_name": "mRNA branch site recognition", "definition": "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome. [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1327284", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA processing", "definition": "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. [GOC:ai]"}
{"concept_id": "C1327285", "aliases": ["down regulation of mRNA processing", "down-regulation of mRNA processing", "downregulation of mRNA processing"], "types": ["T045"], "canonical_name": "negative regulation of mRNA processing", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing. [GOC:ai]"}
{"concept_id": "C1327286", "aliases": ["up-regulation of mRNA processing", "up regulation of mRNA processing", "upregulation of mRNA processing"], "types": ["T045"], "canonical_name": "positive regulation of mRNA processing", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA processing. [GOC:ai]"}
{"concept_id": "C1327287", "aliases": [], "types": ["T045"], "canonical_name": "mRNA stabilization", "definition": "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules. [GOC:jid]"}
{"concept_id": "C1327288", "aliases": [], "types": ["T045"], "canonical_name": "RNA destabilization", "definition": "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. [GOC:ai]"}
{"concept_id": "C1327289", "aliases": [], "types": ["T045"], "canonical_name": "RNA splicing, via endonucleolytic cleavage and ligation", "definition": "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1327290", "aliases": [], "types": ["T045"], "canonical_name": "RNA exon ligation", "definition": "The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction. [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1327291", "aliases": [], "types": ["T045"], "canonical_name": "tRNA-type intron splice site recognition and cleavage", "definition": "RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs. [GOC:krc, GOC:mah, ISBN:0879695897]"}
{"concept_id": "C1327292", "aliases": ["spliceosomal catalysis", "RNA splicing factor activity, transesterification mechanism"], "types": ["T045"], "canonical_name": "RNA splicing, via transesterification reactions", "definition": "Splicing of RNA via a series of two transesterification reactions. [GOC:krc]"}
{"concept_id": "C1327293", "aliases": [], "types": ["T045"], "canonical_name": "RNA splicing, via transesterification reactions with bulged adenosine as nucleophile", "definition": "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure. [GOC:krc, PMID:11377794]"}
{"concept_id": "C1327294", "aliases": [], "types": ["T045"], "canonical_name": "Group II intron splicing", "definition": "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. [GOC:krc, PMID:11377794]"}
{"concept_id": "C1327295", "aliases": [], "types": ["T045"], "canonical_name": "Group III intron splicing", "definition": "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved. [GOC:krc, PMID:11377794]"}
{"concept_id": "C1327296", "aliases": [], "types": ["T045"], "canonical_name": "RNA splicing, via transesterification reactions with guanosine as nucleophile", "definition": "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile. [GOC:krc, PMID:11377794]"}
{"concept_id": "C1327297", "aliases": [], "types": ["T045"], "canonical_name": "Group I intron splicing", "definition": "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize). [GOC:krc, PMID:11377794]"}
{"concept_id": "C1327298", "aliases": ["tRNA 3' processing"], "types": ["T045"], "canonical_name": "tRNA 3'-end processing", "definition": "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA. [GOC:go_curators]"}
{"concept_id": "C1327299", "aliases": ["removal of tRNA 3'-trailer sequence", "tRNA 3'-end cleavage"], "types": ["T045"], "canonical_name": "tRNA 3'-trailer cleavage", "definition": "Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. [GOC:go_curators]"}
{"concept_id": "C1327300", "aliases": [], "types": ["T045"], "canonical_name": "tRNA end turnover", "definition": "The process in which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA. [GOC:go_curators]"}
{"concept_id": "C1327302", "aliases": ["up regulation of viral transcription", "up-regulation of viral transcription", "upregulation of viral transcription"], "types": ["T045"], "canonical_name": "positive regulation of viral transcription", "definition": "Any process that activates or increases the frequency, rate or extent of viral transcription. [GOC:ai]"}
{"concept_id": "C1327303", "aliases": ["mRNA transcription from RNA polymerase II promoter", "mRNA transcription from Pol II promoter"], "types": ["T045"], "canonical_name": "mRNA transcription by RNA polymerase II", "definition": "The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1327304", "aliases": ["5S class rRNA transcription from RNA polymerase III type 1 promoter", "5S rRNA transcription"], "types": ["T045"], "canonical_name": "5S class rRNA transcription by RNA polymerase III", "definition": "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter. [GOC:jl, GOC:txnOH, ISBN:0321000382, PMID:12381659]"}
{"concept_id": "C1327305", "aliases": ["rRNA transcription from mitochondrial promoter"], "types": ["T045"], "canonical_name": "mitochondrial rRNA transcription", "definition": "The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template. [GOC:jl, PMID:23632312]"}
{"concept_id": "C1327306", "aliases": ["rRNA transcription from plastid promoter"], "types": ["T045"], "canonical_name": "plastid rRNA transcription", "definition": "The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1327307", "aliases": ["transcription of nucleolar large rRNA by RNA polymerase I", "transcription of nuclear rRNA large Pol I transcript", "transcription of nuclear large rRNA transcript from RNA polymerase I promoter"], "types": ["T045"], "canonical_name": "nucleolar large rRNA transcription by RNA polymerase I", "definition": "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I. [GOC:jl, GOC:txnOH, ISBN:0321000382]"}
{"concept_id": "C1327308", "aliases": ["snRNA transcription from RNA polymerase II promoter", "snRNA transcription from Pol II promoter"], "types": ["T045"], "canonical_name": "snRNA transcription by RNA polymerase II", "definition": "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1327309", "aliases": ["snRNA transcription from RNA polymerase III promoter", "snRNA transcription from Pol III promoter"], "types": ["T045"], "canonical_name": "snRNA transcription by RNA polymerase III", "definition": "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1327310", "aliases": ["transcription from plastid promoter"], "types": ["T045"], "canonical_name": "plastid transcription", "definition": "The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1327311", "aliases": ["transcription termination from Pol II promoter, poly(A) coupled"], "types": ["T045"], "canonical_name": "transcription termination from Pol II promoter, RNA polymerase(A) coupled"}
{"concept_id": "C1327313", "aliases": ["tRNA transcription from Pol III promoter", "tRNA transcription from RNA polymerase III promoter"], "types": ["T045"], "canonical_name": "tRNA transcription by RNA polymerase III", "definition": "The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter. [GOC:jl, ISBN:0321000382]"}
{"concept_id": "C1327314", "aliases": ["D-glucarate metabolism", "saccharate metabolic process", "saccharate metabolism"], "types": ["T044"], "canonical_name": "D-glucarate metabolic process", "definition": "The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose. [GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1327315", "aliases": ["PHB metabolic process", "PHB metabolism", "poly-hydroxybutyrate metabolism"], "types": ["T044"], "canonical_name": "poly-hydroxybutyrate metabolic process", "definition": "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells. [GOC:jl, PMID:18640095]"}
{"concept_id": "C1327316", "aliases": ["pyruvate synthesis", "pyruvate anabolism", "pyruvate formation", "pyruvate biosynthesis"], "types": ["T044"], "canonical_name": "pyruvate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate. [GOC:go_curators]"}
{"concept_id": "C1327317", "aliases": ["pyruvate breakdown", "pyruvate catabolism", "pyruvate degradation"], "types": ["T044"], "canonical_name": "pyruvate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate. [GOC:go_curators]"}
{"concept_id": "C1327318", "aliases": ["quinolinate metabolism"], "types": ["T044"], "canonical_name": "quinolinate metabolic process", "definition": "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. [GOC:ai]"}
{"concept_id": "C1327319", "aliases": ["trisporic acid metabolism"], "types": ["T044"], "canonical_name": "trisporic acid metabolic process", "definition": "The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota. [GOC:ai]"}
{"concept_id": "C1327320", "aliases": ["trisporic acid anabolism", "trisporic acid formation", "trisporic acid biosynthesis", "trisporic acid synthesis"], "types": ["T044"], "canonical_name": "trisporic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of trisporic acid. [GOC:ai]"}
{"concept_id": "C1327321", "aliases": ["D-glucuronate metabolism"], "types": ["T044"], "canonical_name": "D-glucuronate metabolic process", "definition": "The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C1327322", "aliases": ["teichuronic acid metabolism"], "types": ["T044"], "canonical_name": "teichuronic acid metabolic process", "definition": "The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria. [ISBN:0815108893]"}
{"concept_id": "C1327323", "aliases": ["hydrogen peroxide metabolism", "H2O2 metabolic process"], "types": ["T044"], "canonical_name": "hydrogen peroxide metabolic process", "definition": "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:jl, PMID:21734470]"}
{"concept_id": "C1327324", "aliases": ["hydrogen peroxide biosynthesis", "H2O2 biosynthetic process", "hydrogen peroxide generation", "hydrogen peroxide anabolism", "hydrogen peroxide synthesis", "hydrogen peroxide formation"], "types": ["T044"], "canonical_name": "hydrogen peroxide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:ai]"}
{"concept_id": "C1327325", "aliases": ["hydrogen peroxide degradation", "H2O2 catabolic process", "hydrogen peroxide catabolism", "hydrogen peroxide breakdown"], "types": ["T044"], "canonical_name": "hydrogen peroxide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). [GOC:jl]"}
{"concept_id": "C1327327", "aliases": ["peptide stabilisation"], "types": ["T044"], "canonical_name": "peptide stabilization", "definition": "Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded. [GOC:ai]"}
{"concept_id": "C1327328", "aliases": [], "types": ["T044"], "canonical_name": "peptide antigen stabilization", "definition": "Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded. [GOC:ai]"}
{"concept_id": "C1327329", "aliases": ["phytochelatin metabolism"], "types": ["T044"], "canonical_name": "phytochelatin metabolic process", "definition": "The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. [ISBN:0198506732]"}
{"concept_id": "C1327330", "aliases": ["phytochelatin anabolism", "phytochelatin biosynthesis", "phytochelatin synthesis", "phytochelatin formation", "cadystin biosynthetic process"], "types": ["T044"], "canonical_name": "phytochelatin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. [ISBN:0198506732]"}
{"concept_id": "C1327331", "aliases": ["pheromone metabolism"], "types": ["T044"], "canonical_name": "pheromone metabolic process", "definition": "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. [ISBN:0198506732]"}
{"concept_id": "C1327333", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine phosphorylation", "definition": "The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine. [RESID:AA0034]"}
{"concept_id": "C1327334", "aliases": [], "types": ["T044"], "canonical_name": "regulation of peptidyl-tyrosine phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai]"}
{"concept_id": "C1327335", "aliases": ["down regulation of peptidyl-tyrosine phosphorylation", "downregulation of peptidyl-tyrosine phosphorylation", "down-regulation of peptidyl-tyrosine phosphorylation"], "types": ["T044"], "canonical_name": "negative regulation of peptidyl-tyrosine phosphorylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai]"}
{"concept_id": "C1327336", "aliases": ["up-regulation of peptidyl-tyrosine phosphorylation", "up regulation of peptidyl-tyrosine phosphorylation", "upregulation of peptidyl-tyrosine phosphorylation"], "types": ["T044"], "canonical_name": "positive regulation of peptidyl-tyrosine phosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai]"}
{"concept_id": "C1327339", "aliases": ["beta-amyloid metabolism", "amyloid-beta metabolism", "beta-amyloid metabolic process"], "types": ["T044"], "canonical_name": "amyloid-beta metabolic process", "definition": "The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). [GOC:ai]"}
{"concept_id": "C1327340", "aliases": ["amyloid precursor protein metabolism", "APP metabolic process", "APP metabolism"], "types": ["T044"], "canonical_name": "amyloid precursor protein metabolic process", "definition": "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators]"}
{"concept_id": "C1327341", "aliases": ["regulation of lipoprotein metabolism"], "types": ["T044"], "canonical_name": "regulation of lipoprotein metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. [GOC:ai]"}
{"concept_id": "C1327342", "aliases": ["down regulation of lipoprotein metabolic process", "negative regulation of lipoprotein metabolism", "downregulation of lipoprotein metabolic process", "down-regulation of lipoprotein metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of lipoprotein metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. [GOC:ai]"}
{"concept_id": "C1327343", "aliases": ["up regulation of lipoprotein metabolic process", "up-regulation of lipoprotein metabolic process", "upregulation of lipoprotein metabolic process", "positive regulation of lipoprotein metabolism"], "types": ["T044"], "canonical_name": "positive regulation of lipoprotein metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. [GOC:ai]"}
{"concept_id": "C1327344", "aliases": ["cytochrome b6f complex biogenesis"], "types": ["T044"], "canonical_name": "cytochrome b6f complex assembly", "definition": "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents. [GOC:tb]"}
{"concept_id": "C1327346", "aliases": [], "types": ["T044"], "canonical_name": "copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide", "definition": "The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide. [RESID:AA0355]"}
{"concept_id": "C1327347", "aliases": [], "types": ["T044"], "canonical_name": "iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation", "definition": "The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase. [RESID:AA0334]"}
{"concept_id": "C1327348", "aliases": [], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide", "definition": "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide. [RESID:AA0357]"}
{"concept_id": "C1327349", "aliases": ["iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide"], "types": ["T044"], "canonical_name": "iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide", "definition": "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide. [RESID:AA0331]"}
{"concept_id": "C1327350", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide", "definition": "The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide. [RESID:AA0355]"}
{"concept_id": "C1327351", "aliases": [], "types": ["T044"], "canonical_name": "isopeptide cross-linking via N-(L-isoglutamyl)-glycine", "definition": "The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25. [PMID:14531691, RESID:AA0360]"}
{"concept_id": "C1327352", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine", "definition": "The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine. [PMID:12696888, RESID:AA0342]"}
{"concept_id": "C1327353", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine", "definition": "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine. [PMID:12696888, RESID:AA0341]"}
{"concept_id": "C1327354", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine", "definition": "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine. [PMID:12696888, RESID:AA0340]"}
{"concept_id": "C1327355", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 4-amino-3-isothiazolidinone", "definition": "The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue. [GOC:jid, GOC:jsg]"}
{"concept_id": "C1327356", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine", "definition": "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water. [GOC:jid, PMID:12802338, PMID:12802339, RESID:AA0344]"}
{"concept_id": "C1327357", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-cysteinyl-5-imidazolinone glycine", "definition": "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water. [RESID:AA0188]"}
{"concept_id": "C1327358", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via L-cysteinyl-L-selenocysteine", "definition": "The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P. [RESID:AA0358]"}
{"concept_id": "C1327359", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium", "definition": "The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium. [RESID:AA0348]"}
{"concept_id": "C1327360", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-arginine acetylation", "definition": "The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase. [GOC:jsg, PMID:12883043, RESID:AA0354]"}
{"concept_id": "C1327361", "aliases": ["N-terminal protein amino acid carbamylation"], "types": ["T044"], "canonical_name": "N-terminal protein amino acid carbamoylation", "definition": "The carbamoylation of the N-terminal amino acid of proteins. [GOC:ai]"}
{"concept_id": "C1327362", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-alanine N-carbamoylation", "definition": "The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine. [RESID:AA0343]"}
{"concept_id": "C1327363", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid carboxylation", "definition": "The carboxylation of the N-terminal amino acid of proteins. [GOC:ai]"}
{"concept_id": "C1327364", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-methionine carboxylation", "definition": "The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine. [RESID:AA0363]"}
{"concept_id": "C1327365", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-isoleucine methylation", "definition": "The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine. [RESID:AA0336]"}
{"concept_id": "C1327366", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-leucine methylation", "definition": "The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine. [RESID:AA0337]"}
{"concept_id": "C1327367", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-tyrosine methylation", "definition": "The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine. [RESID:AA0338]"}
{"concept_id": "C1327368", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine S-carbamoylation", "definition": "The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine. [RESID:AA0332]"}
{"concept_id": "C1327369", "aliases": ["formation of peptidyl-S-cyanocysteine", "formation of peptidyl-serine thiocyanate ester"], "types": ["T044"], "canonical_name": "peptidyl-S-carbamoyl-L-cysteine dehydration", "definition": "The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine. [PMID:12586941, RESID:AA0333]"}
{"concept_id": "C1327370", "aliases": ["peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine", "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine", "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine"], "types": ["T044"], "canonical_name": "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine", "definition": "The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide. [PMID:10411887, RESID:AA0347]"}
{"concept_id": "C1327371", "aliases": ["peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine", "peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine", "peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine"], "types": ["T044"], "canonical_name": "peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine", "definition": "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine. [RESID:AA0346]"}
{"concept_id": "C1327372", "aliases": ["peptidyl trimethyl lysine hydroxylase activity", "peptidyl-trimethyl-lysine hydroxylase activity"], "types": ["T044"], "canonical_name": "peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine", "definition": "The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine. [RESID:AA0359]"}
{"concept_id": "C1327374", "aliases": ["peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process", "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation", "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis", "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis", "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism"], "types": ["T044"], "canonical_name": "peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine", "definition": "The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine. [PSI-MOD:00292]"}
{"concept_id": "C1327375", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-selenocysteine modification", "definition": "The modification of peptidyl-selenocysteine. [GOC:ai]"}
{"concept_id": "C1327377", "aliases": ["protein carbamoylation"], "types": ["T044"], "definition": "The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2. [GOC:ai]", "canonical_name": "protein amino acid carbamoylation"}
{"concept_id": "C1327378", "aliases": ["sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway", "sterol depletion response, SREBP cleavage", "SREBP cleavage"], "types": ["T044"], "canonical_name": "sterol regulatory element binding protein cleavage", "definition": "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids. [GOC:bf, GOC:vw, PMID:12923525]"}
{"concept_id": "C1327379", "aliases": [], "types": ["T044"], "canonical_name": "protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine", "definition": "The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine. [PMID:8611516, RESID:AA0352]"}
{"concept_id": "C1327380", "aliases": [], "types": ["T044"], "canonical_name": "protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine", "definition": "The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine. [RESID:AA0353]"}
{"concept_id": "C1327381", "aliases": [], "types": ["T044"], "canonical_name": "protein-FMN linkage via O3-riboflavin phosphoryl-L-serine", "definition": "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine. [RESID:AA0350]"}
{"concept_id": "C1327382", "aliases": [], "types": ["T044"], "canonical_name": "protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine", "definition": "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine. [RESID:AA0349]"}
{"concept_id": "C1327383", "aliases": [], "types": ["T044"], "canonical_name": "protein-FMN linkage via S-(4a-FMN)-L-cysteine", "definition": "The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine. [RESID:AA0351]"}
{"concept_id": "C1327384", "aliases": ["protein monoubiquitylation", "protein monoubiquitinylation"], "types": ["T044"], "canonical_name": "protein monoubiquitination", "definition": "Addition of a single ubiquitin group to a protein. [GOC:ai]"}
{"concept_id": "C1327385", "aliases": ["protein polyubiquitylation", "protein polyubiquitinylation"], "types": ["T044"], "canonical_name": "protein polyubiquitination", "definition": "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. [ISBN:0815316194]"}
{"concept_id": "C1327386", "aliases": ["positive regulation of protein stability", "protein stabilisation"], "types": ["T044"], "definition": "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]", "canonical_name": "protein stabilization"}
{"concept_id": "C1327387", "aliases": ["receptor metabolism"], "types": ["T044"], "canonical_name": "receptor metabolic process", "definition": "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:jl]"}
{"concept_id": "C1327388", "aliases": ["regulation of sulfur metabolism", "regulation of sulphur metabolic process", "regulation of sulphur metabolism"], "types": ["T044"], "canonical_name": "regulation of sulfur metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. [GOC:go_curators]"}
{"concept_id": "C1327389", "aliases": ["sulphate assimilation via adenylyl sulphate reduction"], "types": ["T044"], "canonical_name": "sulfate assimilation via adenylyl sulfate reduction", "definition": "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase. [EC:1.8.99.2]"}
{"concept_id": "C1327390", "aliases": ["retinaldehyde metabolism", "retinal metabolism", "retinal metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. [ISBN:0198506732]", "canonical_name": "retinaldehyde metabolic process"}
{"concept_id": "C1327391", "aliases": ["vitamin B1 and derivative metabolism", "thiamin and derivative metabolic process", "vitamin B1 and derivative metabolic process", "thiamin-containing compound metabolic process", "thiamine-containing compound metabolism", "thiamine and derivative metabolism", "thiamin and derivative metabolism", "thiamine and derivative metabolic process"], "types": ["T044"], "canonical_name": "thiamine-containing compound metabolic process", "definition": "The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it. [GOC:jl]"}
{"concept_id": "C1327392", "aliases": ["vitamin B1 and derivative biosynthetic process", "vitamin B1 and derivative biosynthesis", "thiamine and derivative biosynthetic process", "thiamine-containing compound formation", "thiamin and derivative biosynthesis", "thiamine-containing compound anabolism", "thiamin-containing compound biosynthetic process", "thiamine-containing compound biosynthesis", "thiamine and derivative biosynthesis", "thiamine-containing compound synthesis", "thiamin and derivative biosynthetic process"], "types": ["T044"], "canonical_name": "thiamine-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds. [GOC:jl]"}
{"concept_id": "C1327393", "aliases": ["thiamin and derivative catabolism", "thiamine-containing compound catabolism", "thiamin-containing compound catabolic process", "vitamin B1 and derivative catabolism", "thiamin and derivative catabolic process", "thiamine and derivative catabolic process", "thiamine and derivative catabolism", "vitamin B1 and derivative catabolic process", "thiamine-containing compound degradation", "thiamine-containing compound breakdown"], "types": ["T044"], "canonical_name": "thiamine-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it. [GOC:jl]"}
{"concept_id": "C1327394", "aliases": ["riboflavin and derivative metabolic process", "vitamin B2 and derivative metabolism", "vitamin B2 and derivative metabolic process"], "types": ["T044"], "canonical_name": "riboflavin and derivative metabolism"}
{"concept_id": "C1327395", "aliases": ["vitamin B2 and derivative biosynthetic process", "riboflavin and derivative biosynthetic process", "vitamin B2 and derivative biosynthesis"], "types": ["T044"], "canonical_name": "riboflavin and derivative biosynthesis"}
{"concept_id": "C1327396", "aliases": ["vitamin B2 and derivative catabolic process", "vitamin B2 and derivative catabolism", "riboflavin and derivative catabolic process"], "types": ["T044"], "canonical_name": "riboflavin and derivative catabolism"}
{"concept_id": "C1327397", "aliases": ["vitamin B6 metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]", "canonical_name": "vitamin B6 metabolic process"}
{"concept_id": "C1327398", "aliases": ["pyridoxal metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. [GOC:jl, http://www.mblab.gla.ac.uk/]", "canonical_name": "pyridoxal metabolism"}
{"concept_id": "C1327399", "aliases": ["pyridoxamine metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. [GOC:jl]", "canonical_name": "pyridoxamine metabolic process"}
{"concept_id": "C1327400", "aliases": ["organismal physiological process"], "types": ["T038"], "canonical_name": "multicellular organismal process", "definition": "Any biological process, occurring at the level of a multicellular organism, pertinent to its function. [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]"}
{"concept_id": "C1327401", "aliases": [], "types": ["T039"], "canonical_name": "regulation of bone remodeling", "definition": "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. [GOC:ai]"}
{"concept_id": "C1327402", "aliases": ["downregulation of bone remodeling", "down regulation of bone remodeling", "down-regulation of bone remodeling"], "types": ["T039"], "canonical_name": "negative regulation of bone remodeling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. [GOC:ai]"}
{"concept_id": "C1327403", "aliases": ["up regulation of bone remodeling", "up-regulation of bone remodeling", "upregulation of bone remodeling"], "types": ["T039"], "canonical_name": "positive regulation of bone remodeling", "definition": "Any process that activates or increases the frequency, rate or extent of bone remodeling. [GOC:ai]"}
{"concept_id": "C1327404", "aliases": [], "types": ["T042"], "canonical_name": "regulation of blood vessel size"}
{"concept_id": "C1327405", "aliases": [], "types": ["T039"], "canonical_name": "regulation of vascular permeability", "definition": "Any process that modulates the extent to which blood vessels can be pervaded by fluid. [GOC:jl]"}
{"concept_id": "C1327406", "aliases": ["down-regulation of vascular permeability", "down regulation of vascular permeability", "downregulation of vascular permeability"], "types": ["T039"], "canonical_name": "negative regulation of vascular permeability", "definition": "Any process that reduces the extent to which blood vessels can be pervaded by fluid. [GOC:jl]"}
{"concept_id": "C1327407", "aliases": ["upregulation of vascular permeability", "up-regulation of vascular permeability", "up regulation of vascular permeability"], "types": ["T039"], "canonical_name": "positive regulation of vascular permeability", "definition": "Any process that increases the extent to which blood vessels can be pervaded by fluid. [GOC:jl]"}
{"concept_id": "C1327408", "aliases": [], "types": ["T039"], "canonical_name": "circumnutation", "definition": "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth. [GOC:mtg_MIT_16mar07, ISBN:0192801023]"}
{"concept_id": "C1327409", "aliases": [], "types": ["T042"], "canonical_name": "regulation of saliva secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1327410", "aliases": ["up-regulation of saliva secretion", "up regulation of saliva secretion", "upregulation of saliva secretion"], "types": ["T042"], "canonical_name": "positive regulation of saliva secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva. [GOC:ai]"}
{"concept_id": "C1327411", "aliases": ["exogenous peptide antigen processing and presentation via MHC class I", "antigen presentation, exogenous antigen via major histocompatibility complex class I", "antigen presentation, exogenous antigen via MHC class I"], "types": ["T043"], "canonical_name": "antigen processing and presentation of exogenous peptide antigen via MHC class I", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1327412", "aliases": [], "types": ["T043"], "canonical_name": "antigen presentation, exogenous antigen via MHC class II"}
{"concept_id": "C1327413", "aliases": [], "types": ["T040"], "definition": "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]", "canonical_name": "cytokine production"}
{"concept_id": "C1327430", "aliases": ["regulation of cytokine anabolism", "regulation of cytokine formation", "regulation of cytokine biosynthesis", "regulation of cytokine synthesis"], "types": ["T040"], "canonical_name": "regulation of cytokine production", "definition": "Any process that modulates the frequency, rate, or extent of production of a cytokine. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327431", "aliases": ["negative regulation of cytokine formation", "downregulation of cytokine biosynthetic process", "downregulation of cytokine production", "down-regulation of cytokine production", "down-regulation of cytokine biosynthetic process", "down regulation of cytokine production", "down regulation of cytokine biosynthetic process", "negative regulation of cytokine anabolism", "negative regulation of cytokine synthesis", "negative regulation of cytokine biosynthesis"], "types": ["T040"], "canonical_name": "negative regulation of cytokine production", "definition": "Any process that stops, prevents, or reduces the rate of production of a cytokine. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327432", "aliases": ["up-regulation of cytokine production", "up regulation of cytokine production", "upregulation of cytokine production"], "types": ["T040"], "canonical_name": "positive regulation of cytokine production", "definition": "Any process that activates or increases the frequency, rate or extent of production of a cytokine. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327433", "aliases": [], "types": ["T046"], "canonical_name": "encapsulation of foreign target", "definition": "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization. [GO_REF:0000022, GOC:bf, PMID:11846478, PMID:12225920]"}
{"concept_id": "C1327440", "aliases": [], "types": ["T046"], "canonical_name": "regulation of inflammatory response", "definition": "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai]"}
{"concept_id": "C1327441", "aliases": ["down-regulation of inflammatory response", "down regulation of inflammatory response", "anti-inflammatory response", "downregulation of inflammatory response"], "types": ["T040"], "canonical_name": "negative regulation of inflammatory response", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]"}
{"concept_id": "C1327442", "aliases": ["up-regulation of inflammatory response", "upregulation of inflammatory response", "up regulation of inflammatory response"], "types": ["T040"], "canonical_name": "positive regulation of inflammatory response", "definition": "Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai]"}
{"concept_id": "C1327443", "aliases": [], "types": ["T046"], "canonical_name": "regulation of type I hypersensitivity", "definition": "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response. [ISBN:0781735149]"}
{"concept_id": "C1327444", "aliases": ["down regulation of type I hypersensitivity", "downregulation of type I hypersensitivity", "down-regulation of type I hypersensitivity"], "types": ["T040"], "canonical_name": "negative regulation of type I hypersensitivity", "definition": "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327445", "aliases": ["up-regulation of type I hypersensitivity", "upregulation of type I hypersensitivity", "up regulation of type I hypersensitivity"], "types": ["T040"], "canonical_name": "positive regulation of type I hypersensitivity", "definition": "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327446", "aliases": [], "types": ["T046"], "definition": "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell. [GOC:add, ISBN:0781735149]", "canonical_name": "type IIa hypersensitivity"}
{"concept_id": "C1327447", "aliases": [], "types": ["T046"], "canonical_name": "regulation of type IIa hypersensitivity", "definition": "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327448", "aliases": ["down-regulation of type IIa hypersensitivity", "downregulation of type IIa hypersensitivity", "down regulation of type IIa hypersensitivity"], "types": ["T040"], "canonical_name": "negative regulation of type IIa hypersensitivity", "definition": "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327449", "aliases": ["up-regulation of type IIa hypersensitivity", "upregulation of type IIa hypersensitivity", "up regulation of type IIa hypersensitivity"], "types": ["T040"], "canonical_name": "positive regulation of type IIa hypersensitivity", "definition": "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327450", "aliases": ["type IIb hypersensitivity"], "types": ["T046"], "definition": "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors. [GOC:add, ISBN:0781735149]", "canonical_name": "type V hypersensitivity"}
{"concept_id": "C1327451", "aliases": [], "types": ["T046"], "canonical_name": "regulation of type IIb hypersensitivity", "definition": "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327452", "aliases": ["down-regulation of type IIb hypersensitivity", "downregulation of type IIb hypersensitivity", "down regulation of type IIb hypersensitivity"], "types": ["T040"], "canonical_name": "negative regulation of type IIb hypersensitivity", "definition": "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327453", "aliases": ["up-regulation of type IIb hypersensitivity", "up regulation of type IIb hypersensitivity", "upregulation of type IIb hypersensitivity"], "types": ["T040"], "canonical_name": "positive regulation of type IIb hypersensitivity", "definition": "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327454", "aliases": [], "types": ["T046"], "definition": "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue. [GOC:add, ISBN:0781735149]", "canonical_name": "type III hypersensitivity"}
{"concept_id": "C1327455", "aliases": [], "types": ["T046"], "canonical_name": "regulation of type III hypersensitivity", "definition": "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327456", "aliases": ["downregulation of type III hypersensitivity", "down regulation of type III hypersensitivity", "down-regulation of type III hypersensitivity"], "types": ["T040"], "canonical_name": "negative regulation of type III hypersensitivity", "definition": "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327457", "aliases": ["upregulation of type III hypersensitivity", "up regulation of type III hypersensitivity", "up-regulation of type III hypersensitivity"], "types": ["T040"], "canonical_name": "positive regulation of type III hypersensitivity", "definition": "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1327458", "aliases": [], "types": ["T040"], "canonical_name": "regulation of immune response", "definition": "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]"}
{"concept_id": "C1327459", "aliases": ["downregulation of immune response", "down-regulation of immune response", "down regulation of immune response"], "types": ["T040"], "canonical_name": "negative regulation of immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]"}
{"concept_id": "C1327460", "aliases": ["up-regulation of immune response", "upregulation of immune response", "up regulation of immune response"], "types": ["T040"], "canonical_name": "positive regulation of immune response", "definition": "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]"}
{"concept_id": "C1327461", "aliases": [], "types": ["T040"], "canonical_name": "hair cycle", "definition": "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. [GOC:go_curators, PMID:12230507]"}
{"concept_id": "C1327462", "aliases": [], "types": ["T040"], "canonical_name": "hair regression"}
{"concept_id": "C1327463", "aliases": [], "types": ["T040"], "canonical_name": "hair shedding"}
{"concept_id": "C1327464", "aliases": [], "types": ["T040"], "canonical_name": "regulation of hair cycle", "definition": "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. [GOC:go_curators, PMID:12230507]"}
{"concept_id": "C1327465", "aliases": ["downregulation of hair cycle", "down regulation of hair cycle", "down-regulation of hair cycle"], "types": ["T040"], "canonical_name": "negative regulation of hair cycle", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. [GOC:go_curators, PMID:12230507]"}
{"concept_id": "C1327466", "aliases": ["up-regulation of hair cycle", "upregulation of hair cycle", "up regulation of hair cycle"], "types": ["T040"], "canonical_name": "positive regulation of hair cycle", "definition": "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. [GOC:go_curators, PMID:12230507]"}
{"concept_id": "C1327471", "aliases": ["neurophysiological process", "neurological system process"], "types": ["T040"], "canonical_name": "nervous system process", "definition": "A organ system process carried out by any of the organs or tissues of neurological system. [GOC:ai, GOC:mtg_cardio]"}
{"concept_id": "C1327472", "aliases": ["sensory detection of mechanical stimulus during echolocation", "sensory transduction of mechanical stimulus during echolocation", "echolocation, sensory transduction of mechanical stimulus", "echolocation, detection of mechanical stimulus", "echolocation, sensory detection of mechanical stimulus"], "types": ["T042"], "canonical_name": "detection of mechanical stimulus involved in echolocation", "definition": "The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327473", "aliases": ["neuromotor process", "neuromuscular physiological process"], "types": ["T040"], "canonical_name": "neuromuscular process", "definition": "Any process pertaining to the functions of the nervous and muscular systems of an organism. [GOC:ai]"}
{"concept_id": "C1327474", "aliases": ["sensory perception of orientation with respect to gravity"], "types": ["T040"], "canonical_name": "equilibrioception", "definition": "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion. [http://www.medterms.com]"}
{"concept_id": "C1327475", "aliases": ["sensory detection of mechanical stimulus during equilibrioception", "equilibrioception, sensory transduction of mechanical stimulus", "equilibrioception, detection of mechanical stimulus", "sensory transduction of mechanical stimulus during equilibrioception", "equilibrioception, sensory detection of mechanical stimulus"], "types": ["T042"], "canonical_name": "detection of mechanical stimulus involved in equilibrioception", "definition": "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327476", "aliases": ["visual perception, detection of light stimulus", "sensory detection of light stimulus during visual perception", "detection of light stimulus involved in visual perception", "visual perception, sensory transduction of light stimulus", "sensory transduction of light during visual perception", "sensory detection of light during visual perception", "visual perception, sensory transduction during perception of light"], "types": ["T042"], "definition": "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]", "canonical_name": "sensory transduction of light stimulus during visual perception"}
{"concept_id": "C1327477", "aliases": ["sensory perception of magnetic field", "magnetoception"], "types": ["T040"], "canonical_name": "magnetoreception", "definition": "The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light. [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]"}
{"concept_id": "C1327478", "aliases": ["magnetoreception through chemical stimulus", "magnetoreception, using chemical stimulus", "magnetoreception by chemical stimulus", "magnetoreception, sensory perception of chemical stimulus"], "types": ["T042"], "canonical_name": "magnetoreception by sensory perception of chemical stimulus", "definition": "The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli. [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]"}
{"concept_id": "C1327479", "aliases": ["magnetoreception, sensory detection of chemical stimulus", "sensory detection of chemical stimulus during magnetoreception", "magnetoreception, sensory transduction of chemical stimulus", "magnetoreception, detection of chemical stimulus", "magnetoception, sensory transduction of chemical stimulus", "sensory transduction of chemical stimulus during magnetoreception"], "types": ["T039"], "canonical_name": "detection of chemical stimulus involved in magnetoreception", "definition": "The series of events involved in magnetoception in which a chemical stimulus is received and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327480", "aliases": ["magnetoreception, sensory perception of electrical stimulus", "magnetoreception by electrical stimulus", "magnetoreception, using electrical stimulus", "magnetoreception through electrical stimulus"], "types": ["T042"], "canonical_name": "magnetoreception by sensory perception of electrical stimulus", "definition": "The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish. [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]"}
{"concept_id": "C1327481", "aliases": ["magnetoception, sensory transduction of electrical stimulus", "magnetoreception, sensory transduction of electrical stimulus", "magnetoreception, detection of electrical stimulus", "magnetoreception, sensory detection of electrical stimulus"], "types": ["T039"], "canonical_name": "detection of electrical stimulus involved in magnetoreception", "definition": "The series of events that contribute to magnetoception in which an electrical stimulus is received and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field. [GOC:ai, GOC:dos, GOC:dph, GOC:tb, PMID:15886990, Wikipedia:Magnetoception]"}
{"concept_id": "C1327483", "aliases": ["magnetoreception, sensory transduction of mechanical stimulus", "magnetoreception, detection of mechanical stimulus", "sensory transduction of mechanical stimulus during magnetoreception", "magnetoception, sensory transduction of mechanical stimulus", "magnetoreception, sensory detection of mechanical stimulus", "sensory detection of mechanical stimulus during magnetoreception"], "types": ["T039"], "canonical_name": "detection of mechanical stimulus involved in magnetoreception", "definition": "The series of events involved in magnetoception in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327485", "aliases": ["sensory detection of chemical stimulus during perception of pain", "perception of pain, sensory detection of chemical stimulus", "perception of pain, detection of chemical stimulus", "sensory transduction of chemical stimulus during perception of pain", "perception of pain, sensory transduction of chemical stimulus"], "types": ["T039"], "canonical_name": "detection of chemical stimulus involved in sensory perception of pain", "definition": "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. [GOC:ai]"}
{"concept_id": "C1327486", "aliases": ["perception of pain, sensory detection of electrical stimulus", "perception of pain, detection of electrical stimulus", "perception of pain, sensory transduction of electrical stimulus"], "types": ["T039"], "canonical_name": "detection of electrical stimulus involved in sensory perception of pain", "definition": "The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]"}
{"concept_id": "C1327487", "aliases": ["perception of pain, detection of mechanical stimulus", "perception of pain, sensory detection of mechanical stimulus", "sensory detection of mechanical stimulus during perception of pain", "sensory transduction of mechanical stimulus during perception of pain", "perception of pain, sensory transduction of mechanical stimulus"], "types": ["T039"], "canonical_name": "detection of mechanical stimulus involved in sensory perception of pain", "definition": "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327489", "aliases": ["perception of smell, sensory transduction of chemical stimulus", "sensory detection of scent", "sensory detection of smell", "sensory detection of chemical stimulus during perception of smell", "sensory transduction of chemical stimulus during perception of smell", "perception of smell, sensory detection of chemical stimulus", "sensory transduction of scent", "sensory transduction of smell", "perception of smell, detection of chemical stimulus"], "types": ["T039"], "canonical_name": "detection of chemical stimulus involved in sensory perception of smell", "definition": "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. [GOC:ai]"}
{"concept_id": "C1327490", "aliases": ["sensory transduction of bitter taste", "perception of bitter taste, detection of chemical stimulus", "perception of bitter taste, sensory transduction of chemical stimulus", "sensory transduction of chemical stimulus during perception of bitter taste", "bitter taste detection", "sensory detection of chemical stimulus during perception of bitter taste", "sensory detection of bitter taste"], "types": ["T043"], "canonical_name": "detection of chemical stimulus involved in sensory perception of bitter taste", "definition": "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. [GOC:go_curators]"}
{"concept_id": "C1327491", "aliases": ["sensory transduction of chemical stimulus during perception of salty taste", "sensory detection of chemical stimulus during perception of salty taste", "perception of salty taste, sensory transduction of chemical stimulus", "sensory transduction of salty taste", "sensory detection of salty taste", "perception of salty taste, detection of chemical stimulus", "salty taste detection"], "types": ["T043"], "canonical_name": "detection of chemical stimulus involved in sensory perception of salty taste", "definition": "The series of events required for a salty taste stimulus to be received and converted to a molecular signal. [GOC:go_curators]"}
{"concept_id": "C1327492", "aliases": ["sensory detection of sour taste", "sensory detection of chemical stimulus during perception of sour taste", "perception of sour taste, detection of chemical stimulus", "sensory transduction of chemical stimulus during perception of sour taste", "sour taste detection", "sensory transduction of sour taste", "perception of sour taste, sensory transduction of chemical stimulus"], "types": ["T043"], "canonical_name": "detection of chemical stimulus involved in sensory perception of sour taste", "definition": "The series of events required for a sour taste stimulus to be received and converted to a molecular signal. [GOC:go_curators]"}
{"concept_id": "C1327493", "aliases": ["sensory detection of sweet taste", "perception of sweet taste, sensory transduction of chemical stimulus", "sensory transduction of sweet taste", "sensory transduction of chemical stimulus during perception of sweet taste", "sensory detection of chemical stimulus during perception of sweet taste", "sweet taste detection", "perception of sweet taste, detection of chemical stimulus"], "types": ["T043"], "canonical_name": "detection of chemical stimulus involved in sensory perception of sweet taste", "definition": "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal. [GOC:go_curators]"}
{"concept_id": "C1327494", "aliases": ["sensory transduction of chemical stimulus during perception of taste", "perception of taste, sensory detection of chemical stimulus", "sensory transduction of taste", "perception of taste, detection of chemical stimulus", "sensory detection of taste", "sensory detection of chemical stimulus during perception of taste", "perception of taste, sensory transduction of chemical stimulus"], "types": ["T039"], "canonical_name": "detection of chemical stimulus involved in sensory perception of taste", "definition": "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. [GOC:ai]"}
{"concept_id": "C1327495", "aliases": ["umami taste detection", "sensory transduction of chemical stimulus during perception of umami taste", "perception of umami taste, sensory transduction of chemical stimulus", "sensory detection of chemical stimulus during perception of umami taste", "sensory transduction of umami taste", "sensory detection of umami taste", "perception of umami taste, detection of chemical stimulus"], "types": ["T040"], "canonical_name": "detection of chemical stimulus involved in sensory perception of umami taste", "definition": "The series of events required for a umami taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. [GOC:ai, GOC:dos, PMID:11894099]"}
{"concept_id": "C1327496", "aliases": ["sensory detection of chemical stimulus", "sensory transduction of chemical stimulus during sensory perception", "sensory transduction of chemical stimulus", "sensory detection of chemical stimulus during sensory perception", "sensory perception, sensory detection of chemical stimulus", "sensory perception, sensory transduction of chemical stimulus"], "types": ["T039"], "canonical_name": "detection of chemical stimulus involved in sensory perception", "definition": "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327497", "aliases": [], "types": ["T039"], "canonical_name": "sensory perception of electrical stimulus", "definition": "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]"}
{"concept_id": "C1327498", "aliases": ["electroceptive sense", "electroception sense"], "types": ["T040"], "canonical_name": "electroception", "definition": "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. [GOC:ai, PMID:10210663, Wikipedia:Electroreception]"}
{"concept_id": "C1327499", "aliases": ["electroception, sensory detection of electrical stimulus", "electroception, sensory transduction of electrical stimulus", "electroception, detection of electrical stimulus", "electroception, sensory transduction"], "types": ["T039"], "canonical_name": "detection of electrical stimulus involved in electroception", "definition": "The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327500", "aliases": ["sensory transduction of electrical stimulus", "sensory transduction of electrical stimulus during sensory perception", "sensory perception, sensory detection of electrical stimulus", "sensory perception, sensory transduction of electrical stimulus", "sensory detection of electrical stimulus", "sensory detection of electrical stimulus during sensory perception"], "types": ["T039"], "canonical_name": "detection of electrical stimulus involved in sensory perception", "definition": "The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327503", "aliases": ["perception of mechanical stimulus", "mechanosensory perception"], "types": ["T042"], "canonical_name": "sensory perception of mechanical stimulus", "definition": "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]"}
{"concept_id": "C1327506", "aliases": ["sensory transduction of mechanical stimulus during perception of touch", "perception of touch, detection of mechanical stimulus", "tactition, sensory detection of mechanical stimulus", "perception of touch, sensory detection of mechanical stimulus", "perception of touch, sensory transduction of mechanical stimulus", "sensory detection of mechanical stimulus during perception of touch"], "types": ["T042"], "canonical_name": "detection of mechanical stimulus involved in sensory perception of touch", "definition": "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327507", "aliases": ["sensory detection of mechanical stimulus", "sensory perception, sensory transduction of mechanical stimulus", "sensory transduction of mechanical stimulus", "sensory detection of mechanical stimulus during sensory perception", "sensory transduction of mechanical stimulus during sensory perception", "sensory perception, sensory detection of mechanical stimulus"], "types": ["T039"], "canonical_name": "detection of mechanical stimulus involved in sensory perception", "definition": "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327511", "aliases": [], "types": ["T042"], "definition": "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect. [GOC:dph, ISBN:0721662544]", "canonical_name": "sensory processing"}
{"concept_id": "C1327512", "aliases": [], "types": ["T042"], "canonical_name": "determination of affect", "definition": "Any process in which an emotional response is associated with a particular sensory stimulation. [GOC:ai, GOC:dph, ISBN:0721662544]"}
{"concept_id": "C1327513", "aliases": [], "types": ["T042"], "canonical_name": "determination of sensory modality", "definition": "The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain. [ISBN:0721619908]"}
{"concept_id": "C1327514", "aliases": [], "types": ["T042"], "canonical_name": "determination of stimulus intensity", "definition": "The determination of the perceived strength of a sensory stimulus. [ISBN:0721619908]"}
{"concept_id": "C1327515", "aliases": [], "types": ["T042"], "canonical_name": "determination of stimulus location", "definition": "The determination of where on the body surface, within the body or in the environment a stimulus originates. [ISBN:0721619908]"}
{"concept_id": "C1327517", "aliases": [], "types": ["T040"], "definition": "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. [GOC:dph]", "canonical_name": "musculoskeletal movement"}
{"concept_id": "C1327518", "aliases": [], "types": ["T040"], "canonical_name": "musculoskeletal movement, spinal reflex action", "definition": "Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord. [GOC:dph]"}
{"concept_id": "C1327519", "aliases": [], "types": ["T040"], "canonical_name": "regulation of balance"}
{"concept_id": "C1327520", "aliases": ["regulation of posture"], "types": ["T040"], "canonical_name": "neuromuscular process controlling posture", "definition": "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. [GOC:dph, GOC:tb]"}
{"concept_id": "C1327521", "aliases": [], "types": ["T040"], "canonical_name": "voluntary musculoskeletal movement", "definition": "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will. [GOC:dph]"}
{"concept_id": "C1327524", "aliases": [], "types": ["T040"], "canonical_name": "fruit dehiscence", "definition": "The process leading to the spontaneous opening of the fruit permitting the escape of seeds. [GOC:tb, ISBN:0471245208]"}
{"concept_id": "C1327525", "aliases": [], "types": ["T042"], "canonical_name": "pollen tube guidance", "definition": "The process in which the growth of pollen tube is directed towards the female gametophyte. [GOC:lr]"}
{"concept_id": "C1327526", "aliases": ["response to circadian rhythm"], "types": ["T040"], "canonical_name": "circadian response"}
{"concept_id": "C1327530", "aliases": [], "types": ["T043"], "canonical_name": "response to chitin", "definition": "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus. [GOC:sm]"}
{"concept_id": "C1327532", "aliases": ["DNA damage response, signal transduction", "response to DNA damage stimulus by intracellular signaling cascade"], "types": ["T043"], "canonical_name": "signal transduction in response to DNA damage", "definition": "A cascade of processes induced by the detection of DNA damage within a cell. [GOC:go_curators]"}
{"concept_id": "C1327533", "aliases": [], "types": ["T044"], "canonical_name": "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "definition": "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage. [PMID:10967424]"}
{"concept_id": "C1327534", "aliases": [], "types": ["T045"], "canonical_name": "DNA damage response, signal transduction resulting in transcription", "definition": "A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. [GOC:go_curators]"}
{"concept_id": "C1327535", "aliases": [], "types": ["T043"], "canonical_name": "response to 1-aminocyclopropane-1-carboxylic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus. [GOC:jl]"}
{"concept_id": "C1327536", "aliases": [], "types": ["T039"], "canonical_name": "detection of electrical stimulus", "definition": "The series of events by which an electrical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327537", "aliases": [], "types": ["T039"], "canonical_name": "detection of mechanical stimulus", "definition": "The series of events by which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]"}
{"concept_id": "C1327538", "aliases": ["chemorepulsion", "chemoaversion"], "types": ["T043"], "canonical_name": "negative chemotaxis", "definition": "The directed movement of a motile cell or organism towards a lower concentration of a chemical. [GOC:ai, GOC:bf, GOC:isa_complete]"}
{"concept_id": "C1327539", "aliases": [], "types": ["T043"], "canonical_name": "regulation of negative chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. [GOC:ai]"}
{"concept_id": "C1327540", "aliases": ["down-regulation of negative chemotaxis", "down regulation of negative chemotaxis", "downregulation of negative chemotaxis"], "types": ["T043"], "canonical_name": "negative regulation of negative chemotaxis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. [GOC:ai]"}
{"concept_id": "C1327541", "aliases": ["up regulation of negative chemotaxis", "upregulation of negative chemotaxis", "up-regulation of negative chemotaxis"], "types": ["T043"], "canonical_name": "positive regulation of negative chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. [GOC:ai]"}
{"concept_id": "C1327542", "aliases": [], "types": ["T043"], "canonical_name": "induction of negative chemotaxis", "definition": "Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. [GOC:ai]"}
{"concept_id": "C1327543", "aliases": ["chemoattraction"], "types": ["T043"], "canonical_name": "positive chemotaxis", "definition": "The directed movement of a motile cell or organism towards a higher concentration of a chemical. [GOC:ai, GOC:bf, GOC:isa_complete]"}
{"concept_id": "C1327544", "aliases": [], "types": ["T043"], "canonical_name": "regulation of positive chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai]"}
{"concept_id": "C1327545", "aliases": ["down regulation of positive chemotaxis", "downregulation of positive chemotaxis", "down-regulation of positive chemotaxis"], "types": ["T043"], "canonical_name": "negative regulation of positive chemotaxis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai]"}
{"concept_id": "C1327546", "aliases": ["upregulation of positive chemotaxis", "up regulation of positive chemotaxis", "up-regulation of positive chemotaxis"], "types": ["T043"], "canonical_name": "positive regulation of positive chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai]"}
{"concept_id": "C1327547", "aliases": [], "types": ["T043"], "canonical_name": "induction of positive chemotaxis", "definition": "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai]"}
{"concept_id": "C1327548", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]"}
{"concept_id": "C1327549", "aliases": ["down regulation of chemotaxis", "downregulation of chemotaxis", "down-regulation of chemotaxis"], "types": ["T043"], "canonical_name": "negative regulation of chemotaxis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]"}
{"concept_id": "C1327550", "aliases": ["up regulation of chemotaxis", "up-regulation of chemotaxis", "upregulation of chemotaxis"], "types": ["T043"], "canonical_name": "positive regulation of chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]"}
{"concept_id": "C1327551", "aliases": [], "types": ["T043"], "canonical_name": "soluble molecule recognition", "definition": "The recognition of soluble molecules in the environment. [GOC:go_curators]"}
{"concept_id": "C1327552", "aliases": ["response to actidione"], "types": ["T040"], "canonical_name": "response to cycloheximide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes. [GOC:ef, ISBN:0198506732]"}
{"concept_id": "C1327553", "aliases": [], "types": ["T040"], "canonical_name": "response to nicotine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]"}
{"concept_id": "C1327554", "aliases": [], "types": ["T043"], "canonical_name": "response to inorganic substance", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm]"}
{"concept_id": "C1327555", "aliases": ["response to boron"], "types": ["T043"], "canonical_name": "response to boron-containing substance", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron-containing substance stimulus. [GOC:sm]"}
{"concept_id": "C1327556", "aliases": [], "types": ["T043"], "canonical_name": "response to carbon dioxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus. [GOC:sm]"}
{"concept_id": "C1327557", "aliases": [], "types": ["T043"], "canonical_name": "response to chlorate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus. [GOC:sm]"}
{"concept_id": "C1327558", "aliases": ["response to metal"], "types": ["T043"], "canonical_name": "response to metal ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. [GOC:sm]"}
{"concept_id": "C1327559", "aliases": ["response to aluminium ion", "response to aluminum"], "types": ["T043"], "canonical_name": "response to aluminum ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus. [GOC:sm]"}
{"concept_id": "C1327560", "aliases": ["response to cesium"], "types": ["T043"], "canonical_name": "response to cesium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus. [GOC:sm]"}
{"concept_id": "C1327561", "aliases": ["response to iron"], "types": ["T043"], "canonical_name": "response to iron ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. [GOC:sm]"}
{"concept_id": "C1327562", "aliases": ["response to iron(II)"], "types": ["T043"], "canonical_name": "response to iron(II) ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. [GOC:sm]"}
{"concept_id": "C1327563", "aliases": ["response to iron(III)"], "types": ["T043"], "canonical_name": "response to iron(III) ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus. [GOC:sm]"}
{"concept_id": "C1327564", "aliases": ["response to manganese"], "types": ["T043"], "canonical_name": "response to manganese ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. [GOC:sm]"}
{"concept_id": "C1327565", "aliases": [], "types": ["T043"], "canonical_name": "detoxification of mercury ion", "definition": "Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0]). [PMID:10774920]"}
{"concept_id": "C1327566", "aliases": ["sequestration of mercury (Hg) ion", "mercury (Hg2+) ion retention", "mercuric ion (Hg2+) sequestering", "storage of mercury (Hg2+) ion", "sequestering of mercury (Hg) ion", "sequestration of mercuric ion (Hg2+)", "mercury (Hg) ion sequestering", "mercury (Hg) ion sequestration", "mercury (Hg2+) ion storage", "sequestering of mercuric ion (Hg2+)", "mercuric ion (Hg2+) sequestration", "retention of mercury (Hg2+) ion"], "types": ["T043"], "canonical_name": "sequestering of mercury", "definition": "The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system. [PMID:10774920]"}
{"concept_id": "C1327567", "aliases": ["response to nickel"], "types": ["T043"], "canonical_name": "response to nickel cation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. [GOC:sm]"}
{"concept_id": "C1327568", "aliases": ["response to zinc"], "types": ["T043"], "canonical_name": "response to zinc ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. [GOC:sm]"}
{"concept_id": "C1327569", "aliases": [], "types": ["T043"], "canonical_name": "response to nitrate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus. [GOC:sm]"}
{"concept_id": "C1327570", "aliases": [], "types": ["T043"], "canonical_name": "response to organic substance", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. [GOC:sm, PMID:23356676]"}
{"concept_id": "C1327571", "aliases": [], "types": ["T043"], "canonical_name": "response to acetate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. [GOC:sm]"}
{"concept_id": "C1327572", "aliases": [], "types": ["T040"], "canonical_name": "response to acid"}
{"concept_id": "C1327573", "aliases": [], "types": ["T044"], "canonical_name": "mycothiol-dependent detoxification of alkylating agent"}
{"concept_id": "C1327574", "aliases": [], "types": ["T043"], "canonical_name": "response to microbial phytotoxin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants. [GOC:sm]"}
{"concept_id": "C1327575", "aliases": [], "types": ["T043"], "canonical_name": "response to mycotoxin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi. [GOC:sm]"}
{"concept_id": "C1327576", "aliases": ["negative geotactic behaviour", "negative gravitactic behavior", "negative geotactic behavior", "negative gravitactic behaviour", "negative taxis in response to gravitytaxis in response to gravitational stimulus", "negative taxis in response to gravity"], "types": ["T043"], "canonical_name": "negative gravitaxis", "definition": "The directed movement of a motile cell or organism away from the source of gravity. [GOC:jid]"}
{"concept_id": "C1327577", "aliases": ["positive taxis in response to gravitytaxis in response to gravitational stimulus", "positive gravitactic behavior", "positive geotactic behaviour", "positive geotactic behavior", "positive gravitactic behaviour", "positive taxis in response to gravity"], "types": ["T043"], "canonical_name": "positive gravitaxis", "definition": "The directed movement of a motile cell or organism towards the source of gravity. [GOC:jid]"}
{"concept_id": "C1327578", "aliases": [], "types": ["T039"], "canonical_name": "shoot gravitropism"}
{"concept_id": "C1327579", "aliases": [], "types": ["T039"], "canonical_name": "positive gravitropism", "definition": "The orientation of plant parts towards gravity. [GOC:sm]"}
{"concept_id": "C1327580", "aliases": [], "types": ["T043"], "canonical_name": "regulation of response to osmotic stress", "definition": "Any process that modulates the rate or extent of the response to osmotic stress. [GOC:ai]"}
{"concept_id": "C1327581", "aliases": [], "types": ["T040"], "canonical_name": "response to ozone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus. [GOC:sm]"}
{"concept_id": "C1327582", "aliases": [], "types": ["T040"], "canonical_name": "nonphotochemical quenching", "definition": "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage. [PMID:10667783, PMID:10938857]"}
{"concept_id": "C1327583", "aliases": ["negative taxis in response to light", "negative phototactic behavior", "negative phototactic behaviour"], "types": ["T043"], "canonical_name": "negative phototaxis", "definition": "The directed movement of a cell or organism away from a source of light. [GOC:ai]"}
{"concept_id": "C1327584", "aliases": ["positive phototactic behaviour", "positive phototactic behavior", "positive taxis in response to light"], "types": ["T043"], "canonical_name": "positive phototaxis", "definition": "The directed movement of a cell or organism towards a source of light. [GOC:ai]"}
{"concept_id": "C1327585", "aliases": ["response to red light stimulus"], "types": ["T039"], "canonical_name": "response to red light", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. [GOC:mtg_far_red, GOC:sm]"}
{"concept_id": "C1327589", "aliases": ["response to X-ray radiation stimulus"], "types": ["T040"], "canonical_name": "response to X-ray", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). [GOC:sm, Wikipedia:X-ray]"}
{"concept_id": "C1327590", "aliases": [], "types": ["T040"], "canonical_name": "response to freezing", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. [GOC:jl]"}
{"concept_id": "C1327591", "aliases": [], "types": ["T040"], "canonical_name": "vernalization response", "definition": "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures. [GOC:tair_curators, ISBN:0521591392]"}
{"concept_id": "C1327592", "aliases": ["defence response to bacterium", "defence response to bacteria", "defense response to bacteria"], "types": ["T040"], "canonical_name": "defense response to bacterium", "definition": "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl]"}
{"concept_id": "C1327593", "aliases": ["defence response to Gram-negative bacteria", "defense response to Gram-negative bacteria", "defence response to Gram-negative bacterium"], "types": ["T046"], "canonical_name": "defense response to Gram-negative bacterium", "definition": "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. [GOC:ai]"}
{"concept_id": "C1327594", "aliases": ["defence response to Gram-positive bacterium", "defense response to Gram-positive bacteria", "defence response to Gram-positive bacteria"], "types": ["T046"], "canonical_name": "defense response to Gram-positive bacterium", "definition": "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai]"}
{"concept_id": "C1327596", "aliases": ["male-specific defense response to bacteria", "male-specific defence response to bacteria", "male-specific defence response to bacterium"], "types": ["T046"], "canonical_name": "male-specific defense response to bacterium", "definition": "A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:ai]"}
{"concept_id": "C1327597", "aliases": ["defence response to fungus", "defence response to fungi", "defense response to fungi"], "types": ["T046"], "canonical_name": "defense response to fungus", "definition": "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. [GOC:ai]"}
{"concept_id": "C1327599", "aliases": [], "types": ["T040"], "canonical_name": "regulation of systemic acquired resistance", "definition": "Any process that modulates the frequency, rate or extent of systemic acquired resistance. [GOC:sm]"}
{"concept_id": "C1327600", "aliases": ["downregulation of systemic acquired resistance", "down regulation of systemic acquired resistance", "down-regulation of systemic acquired resistance"], "types": ["T040"], "canonical_name": "negative regulation of systemic acquired resistance", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of systemic acquired resistance. [GOC:sm]"}
{"concept_id": "C1327604", "aliases": ["defense response to protozoa", "defense response to pathogenic protozoa", "defense response to protozoon", "defence response to protozoa", "defence response to pathogenic protozoa", "defence response to protozoon"], "types": ["T046"], "canonical_name": "defense response to protozoan", "definition": "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism. [GOC:jl]"}
{"concept_id": "C1327606", "aliases": ["regulation of antiviral response"], "types": ["T040"], "canonical_name": "regulation of defense response to virus", "definition": "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. [GOC:ai]"}
{"concept_id": "C1327607", "aliases": ["down-regulation of antiviral response", "down regulation of antiviral response", "negative regulation of antiviral response", "downregulation of antiviral response"], "types": ["T040"], "canonical_name": "negative regulation of defense response to virus", "definition": "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. [GOC:ai]"}
{"concept_id": "C1327608", "aliases": ["negative regulation of antiviral response by host", "negative regulation by host of antiviral response", "downregulation of antiviral response by host", "down regulation of antiviral response by host", "down-regulation of antiviral response by host"], "types": ["T040"], "canonical_name": "negative regulation of defense response to virus by host", "definition": "Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1327609", "aliases": ["regulation by host of antiviral response", "host regulation of antiviral response", "regulation of antiviral response by host"], "types": ["T040"], "canonical_name": "regulation of defense response to virus by host", "definition": "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. [GOC:ai, GOC:dph]"}
{"concept_id": "C1327611", "aliases": [], "types": ["T040"], "canonical_name": "response to starvation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. [GOC:go_curators]"}
{"concept_id": "C1327612", "aliases": ["taxis in response to temperature stimulus"], "types": ["T038"], "definition": "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature. [GOC:cab1, WB_REF:cgc467]", "canonical_name": "thermotaxis"}
{"concept_id": "C1327613", "aliases": ["physiological fear response"], "types": ["T039"], "canonical_name": "fear response", "definition": "The response of an organism to a perceived external threat. [GOC:go_curators]"}
{"concept_id": "C1327614", "aliases": ["response to pain"], "types": ["T039"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain]", "canonical_name": "physiological response to pain"}
{"concept_id": "C1327616", "aliases": ["secretion by cell", "secretion"], "types": ["T043"], "definition": "The controlled release of a substance by a cell or a tissue. [GOC:ai]", "canonical_name": "cellular secretion"}
{"concept_id": "C1327617", "aliases": [], "types": ["T043"], "canonical_name": "arachidonic acid secretion", "definition": "The controlled release of arachidonic acid from a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1327618", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein secretion", "definition": "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai]"}
{"concept_id": "C1327619", "aliases": ["downregulation of protein secretion", "down regulation of protein secretion", "down-regulation of protein secretion"], "types": ["T043"], "canonical_name": "negative regulation of protein secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai]"}
{"concept_id": "C1327620", "aliases": ["up-regulation of protein secretion", "upregulation of protein secretion", "up regulation of protein secretion"], "types": ["T043"], "canonical_name": "positive regulation of protein secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai]"}
{"concept_id": "C1327621", "aliases": ["autotransporter system", "protein secretion by the autotransporter system", "protein secretion by the type V protein secretion system", "type V protein secretion system"], "types": ["T043"], "canonical_name": "protein secretion by the type V secretion system", "definition": "The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway. [GOC:pamgo_curators]"}
{"concept_id": "C1327622", "aliases": ["regulation", "regulation of biological process"], "types": ["T038"], "definition": "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:ai, GOC:go_curators]", "canonical_name": "regulation of physiological process"}
{"concept_id": "C1327623", "aliases": ["regulation of enzyme activity"], "types": ["T044"], "canonical_name": "regulation of catalytic activity", "definition": "Any process that modulates the activity of an enzyme. [GOC:ai, GOC:ebc, GOC:vw]"}
{"concept_id": "C1327624", "aliases": ["down-regulation of metalloenzyme activity", "down regulation of enzyme activity", "downregulation of enzyme activity", "down regulation of metalloenzyme activity", "down-regulation of enzyme activity", "negative regulation of enzyme activity", "downregulation of metalloenzyme activity"], "types": ["T044"], "canonical_name": "negative regulation of catalytic activity", "definition": "Any process that stops or reduces the activity of an enzyme. [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]"}
{"concept_id": "C1327625", "aliases": ["down-regulation of GTP cyclohydrolase I activity", "down regulation of GTP cyclohydrolase I activity", "downregulation of GTP cyclohydrolase I activity"], "types": ["T044"], "canonical_name": "negative regulation of GTP cyclohydrolase I activity", "definition": "Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I. [GOC:jl]"}
{"concept_id": "C1327626", "aliases": ["up-regulation of enzyme activity", "up regulation of enzyme activity", "upregulation of enzyme activity", "positive regulation of enzyme activity"], "types": ["T044"], "canonical_name": "positive regulation of catalytic activity", "definition": "Any process that activates or increases the activity of an enzyme. [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]"}
{"concept_id": "C1327627", "aliases": ["up-regulation of Cdc42 GTPase activity", "upregulation of Cdc42 GTPase activity", "up regulation of Cdc42 GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of Cdc42 GTPase activity"}
{"concept_id": "C1327628", "aliases": ["up-regulation of GTP cyclohydrolase I activity", "upregulation of GTP cyclohydrolase I activity", "up regulation of GTP cyclohydrolase I activity"], "types": ["T044"], "canonical_name": "positive regulation of GTP cyclohydrolase I activity", "definition": "Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I. [GOC:jl]"}
{"concept_id": "C1327629", "aliases": [], "types": ["T044"], "canonical_name": "regulation of GTP cyclohydrolase I activity", "definition": "Any process that modulates the activity of the enzyme GTP cyclohydrolase I. [GOC:jl]"}
{"concept_id": "C1327630", "aliases": [], "types": ["T044"], "canonical_name": "regulation of GTPase activity", "definition": "Any process that modulates the rate of GTP hydrolysis by a GTPase. [GOC:jl, GOC:mah]"}
{"concept_id": "C1327631", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Cdc42 GTPase activity"}
{"concept_id": "C1327632", "aliases": ["regulation of viral life cycle", "regulation of viral reproduction"], "types": ["T038"], "canonical_name": "regulation of viral process", "definition": "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts. [GOC:go_curators, GOC:tb]"}
{"concept_id": "C1327633", "aliases": ["bacteriophage assembly"], "types": ["T040"], "canonical_name": "phage assembly"}
{"concept_id": "C1327634", "aliases": ["spread of virus in host, tissue to tissue", "spread of virus within host, tissue to tissue", "viral spread within host, tissue to tissue", "tissue to tissue spread of virus within host"], "types": ["T040"], "canonical_name": "transport of virus in host, tissue to tissue", "definition": "The transport of a virus between tissues in a multicellular organism. [GOC:bf, GOC:jl, ISBN:0781718325]"}
{"concept_id": "C1327693", "aliases": ["perception of gravity"], "types": ["T043"], "canonical_name": "detection of gravity", "definition": "The series of events in which a gravitational stimulus is received and converted into a molecular signal. [GOC:dos, GOC:hb]"}
{"concept_id": "C1327694", "aliases": ["hearing, sensory transduction of sound", "perception of sound, detection of mechanical stimulus", "detection of mechanical stimulus involved in sensory perception of sound", "perception of sound, sensory transduction of mechanical stimulus", "sensory transduction of mechanical stimulus during perception of sound", "perception of sound, sensory detection of mechanical stimulus", "sensory transduction of sound", "detection of sound"], "types": ["T039"], "definition": "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. [GOC:ai]", "canonical_name": "sensory detection of mechanical stimulus during perception of sound"}
{"concept_id": "C1327698", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase. [GOC:kd]", "canonical_name": "glutaredoxin"}
{"concept_id": "C1327704", "aliases": [], "types": ["T044"], "canonical_name": "photosystem II inhibition"}
{"concept_id": "C1327708", "aliases": [], "types": ["T044"], "canonical_name": "raffinose porin"}
{"concept_id": "C1327729", "aliases": ["septum", "cross wall"], "types": ["T026"], "definition": "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. [GOC:clt, ISBN:0471940526]", "canonical_name": "cell septum"}
{"concept_id": "C1328256", "aliases": ["mitochondrial inner membrane peptidase complex location", "mitochondrion inner membrane peptidase complex location", "mitochondrial inner membrane peptidase complex", "mitochondrion inner membrane peptidase complex"], "types": ["T026"], "definition": "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space. [PMID:10821182, PMID:12191769]", "canonical_name": "IMP"}
{"concept_id": "C1328656", "aliases": [], "types": ["T043"], "canonical_name": "myeloid dendritic cell differentiation", "definition": "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. [CL:0000782, GOC:jl]"}
{"concept_id": "C1328723", "aliases": ["coagulation"], "types": ["T039"], "definition": "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass. [ISBN:0198506732]", "canonical_name": "clotting"}
{"concept_id": "C1328798", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]", "canonical_name": "elastin"}
{"concept_id": "C1328949", "aliases": [], "types": ["T045"], "definition": "The cellular metabolic process in which a cell duplicates one or more molecules of RNA. [GOC:bf, GOC:jl]", "canonical_name": "RNA replication"}
{"concept_id": "C1332873", "aliases": [], "types": ["T033"], "canonical_name": "cementum formation"}
{"concept_id": "C1333380", "aliases": [], "types": ["T033"], "canonical_name": "enamel formation"}
{"concept_id": "C1335464", "aliases": ["pre-replication complex location", "pre-replicative complex location", "pre-replication complex", "pre-replicative complex"], "types": ["T026"], "definition": "A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. [GOC:bf, GOC:bhm, GOC:jh2, Wikipedia:Pre-replication_complex]", "canonical_name": "pre-RC"}
{"concept_id": "C1366839", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "gp130"}
{"concept_id": "C1366904", "aliases": [], "types": ["T026"], "definition": "An intranuclear focus at which aggregated proteins have been sequestered. [GOC:jl]", "canonical_name": "nuclear inclusion body"}
{"concept_id": "C1367884", "aliases": [], "types": ["T026"], "definition": "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores. [GOC:clt]", "canonical_name": "aster"}
{"concept_id": "C1367886", "aliases": [], "types": ["T038"], "definition": "Any process that establishes and transmits the specification of sexual status of an individual organism. [ISBN:0198506732]", "canonical_name": "sex determination"}
{"concept_id": "C1367887", "aliases": [], "types": ["T040"], "definition": "Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. [ISBN:0192801023]", "canonical_name": "homoiothermy"}
{"concept_id": "C1368474", "aliases": ["rosetting"], "types": ["T043"], "canonical_name": "modulation by symbiont of host erythrocyte aggregation", "definition": "Any process in which a symbiont organism modulates the frequency, rate or extent of erythrocyte aggregation in its host organism, e.g. the binding of parasite-infected erythrocytes to uninfected erythrocytes. [GOC:add, GOC:dgh, GOC:mb, GOC:pr, PMID:19467172, PMID:21305024]"}
{"concept_id": "C1383501", "aliases": [], "types": ["T026"], "definition": "Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.", "canonical_name": "cytosol"}
{"concept_id": "C1383609", "aliases": [], "types": ["T044"], "canonical_name": "L-asparagine transporter activity"}
{"concept_id": "C1384314", "aliases": [], "types": ["T026"], "definition": "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over. [ISBN:0198506732]", "canonical_name": "chiasma"}
{"concept_id": "C1442854", "aliases": [], "types": ["T044"], "canonical_name": "transcarboxylase activity"}
{"concept_id": "C1442866", "aliases": ["hydrolase activity, acting on glycosyl bonds"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of any glycosyl bond. [GOC:jl]", "canonical_name": "glycosidase activity"}
{"concept_id": "C1449568", "aliases": ["cotranslational protein modification", "co-translational protein modification", "cotranslational modification"], "types": ["T044"], "definition": "The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome. [GOC:jsg]", "canonical_name": "co-translational modification"}
{"concept_id": "C1450044", "aliases": ["M-phase of mitotic cell cycle", "mitotic M phase"], "types": ["T043"], "definition": "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]", "canonical_name": "M phase of mitotic cell cycle"}
{"concept_id": "C1450045", "aliases": ["meiotic M phase"], "types": ["T043"], "definition": "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle. [GOC:mtg_cell_cycle]", "canonical_name": "M phase of meiotic cell cycle"}
{"concept_id": "C1456459", "aliases": ["chromatin assembly"], "types": ["T045"], "definition": "The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. [PMID:20404130]", "canonical_name": "establishment of chromatin architecture"}
{"concept_id": "C1456768", "aliases": [], "types": ["T026"], "definition": "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell. [GOC:ns]", "canonical_name": "macronucleus"}
{"concept_id": "C1510421", "aliases": ["mitochondrial matrix"], "types": ["T026"], "definition": "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]", "canonical_name": "mitochondrial lumen"}
{"concept_id": "C1510659", "aliases": ["response to osmotic stress", "osmotic stress response", "osmoregulation"], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:jl]", "canonical_name": "osmotic response"}
{"concept_id": "C1510872", "aliases": ["aminophosphonate metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group. [GOC:mah]", "canonical_name": "aminophosphonate metabolism"}
{"concept_id": "C1510884", "aliases": ["down regulation of angiogenesis", "down-regulation of angiogenesis", "negative regulation of angiogenesis", "downregulation of angiogenesis"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. [GOC:go_curators]", "canonical_name": "inhibition of angiogenesis"}
{"concept_id": "C1510891", "aliases": [], "types": ["T044"], "definition": "Binding to an angiotensin receptor. [GOC:mah, GOC:nln]", "canonical_name": "angiotensin receptor binding"}
{"concept_id": "C1511002", "aliases": ["B cell differentiation", "B lymphocyte differentiation", "B-lymphocyte differentiation"], "types": ["T043"], "definition": "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [GO_REF:0000022, GOC:mah]", "canonical_name": "B-cell differentiation"}
{"concept_id": "C1511042", "aliases": ["Balbiani body"], "types": ["T026"], "definition": "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material. [PMID:6541166]", "canonical_name": "mitochondrial cloud"}
{"concept_id": "C1511061", "aliases": [], "types": ["T018"], "definition": "The ventral region of the embryological neural tube, which is comprised mostly of motor neurons.", "canonical_name": "basal plate"}
{"concept_id": "C1511460", "aliases": ["C-X-C chemokine receptor CXCR4 signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]", "canonical_name": "CXCR4 signaling pathway"}
{"concept_id": "C1511570", "aliases": ["cyanoamino acid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group. [GOC:mah, PMID:11575729]", "canonical_name": "cyanoamino acid metabolic process"}
{"concept_id": "C1511616", "aliases": ["hematopoietin/interferon-class (D200-domain) cytokine receptor binding"], "types": ["T044"], "definition": "Binding to a cytokine receptor. [GOC:mah, GOC:vw]", "canonical_name": "cytokine receptor binding"}
{"concept_id": "C1511621", "aliases": [], "types": ["T043"], "definition": "Any process that decreases the frequency, rate or extent of cytolysis.", "canonical_name": "inhibition of cytolysis"}
{"concept_id": "C1511679", "aliases": [], "types": ["T044"], "definition": "DNA Methylation Inhibition involves interference with, or restraint of, the process by which methyl groups are added to genomic DNA nucleotides.", "canonical_name": "inhibition of DNA methylation"}
{"concept_id": "C1511680", "aliases": [], "types": ["T044"], "definition": "Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. [GOC:jl]", "canonical_name": "regulation of DNA methylation"}
{"concept_id": "C1511688", "aliases": [], "types": ["T045"], "definition": "DNA Repair Inhibition involves interference with, or restraint of, the enzymatic restoration of a continuous two-stranded DNA molecule without mismatch from a molecule that contains regions damaged by chemical or radiation exposure or by spontaneous damage.", "canonical_name": "inhibition of DNA repair"}
{"concept_id": "C1511692", "aliases": [], "types": ["T045"], "definition": "DNA Replication Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in the process by which the two strands of a DNA double helix separate and each strand acts as a template for the synthesis of a complementary strand by specific base pairing.", "canonical_name": "inhibition of DNA replication"}
{"concept_id": "C1511806", "aliases": [], "types": ["T042"], "definition": "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. [GOC:isa_complete]", "canonical_name": "developmental process"}
{"concept_id": "C1512128", "aliases": ["receptor tyrosine-protein kinase erbB-2 signaling pathway", "ERBB2 signaling pathway", "HER2 signaling pathway", "ERBB2 signalling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. [GOC:jc, PMID:16460914, Reactome:R-HSA-1227986]", "canonical_name": "NEU signaling"}
{"concept_id": "C1512177", "aliases": ["icosanoid breakdown", "icosanoid catabolic process", "icosanoid degradation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of icosanoid. [GOC:pr, GOC:TermGenie]", "canonical_name": "icosanoid catabolism"}
{"concept_id": "C1512202", "aliases": [], "types": ["T044"], "definition": "Binding to a glucagon receptor. [GOC:mah, GOC:nln]", "canonical_name": "glucagon receptor binding"}
{"concept_id": "C1512207", "aliases": [], "types": ["T039"], "definition": "Gluconeogenesis Inhibition involves interference with, or restraint of, the biosynthesis of glucose from 3-carbon non-carbohydrate precursors, including amino acids.", "canonical_name": "inhibition of gluconeogenesis"}
{"concept_id": "C1512232", "aliases": [], "types": ["T039"], "definition": "Glycolysis Inhibition involves interference with, or restraint of, the activities of the pathway by which glucose is catabolized into two molecules of pyruvic acid with the generation of ATP.", "canonical_name": "inhibition of glycolysis"}
{"concept_id": "C1512467", "aliases": ["histamine breakdown", "histamine degradation", "histamine catabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:jl, ISBN:0395825172]", "canonical_name": "histamine catabolic process"}
{"concept_id": "C1512644", "aliases": ["leukocyte apoptotic process"], "types": ["T043"], "definition": "Any apoptotic process that is observed in leukocytes.", "canonical_name": "leukocyte apoptosis"}
{"concept_id": "C1512646", "aliases": ["downregulation of leukocyte activation", "down-regulation of leukocyte activation", "negative regulation of leukocyte activation", "down regulation of leukocyte activation", "negative regulation of leucocyte activation"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. [GOC:add]", "canonical_name": "negative regulation of immune cell activation"}
{"concept_id": "C1512772", "aliases": ["negative regulation of apoptotic process", "downregulation of apoptosis", "down regulation of apoptosis", "inhibition of apoptosis", "down-regulation of apoptosis", "anti-apoptosis"], "types": ["T043"], "definition": "Any cellular process that decreases the frequency, rate or extent of cell death by apoptosis.", "canonical_name": "negative regulation of apoptosis"}
{"concept_id": "C1512777", "aliases": [], "types": ["T026"], "definition": "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. [GOC:dph, GOC:ef]", "canonical_name": "inhibitory synapse"}
{"concept_id": "C1512795", "aliases": ["inositol phosphate metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:jl]", "canonical_name": "inositol phosphate metabolism"}
{"concept_id": "C1512810", "aliases": ["cell adhesion mediated by integrin complex"], "types": ["T043"], "definition": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. [GOC:add, PMID:12213832, PMID:14754902]", "canonical_name": "cell adhesion mediated by integrin"}
{"concept_id": "C1513087", "aliases": ["positive regulation of meiotic nuclear division", "up-regulation of meiosis", "up regulation of meiosis", "positive regulation of meiosis"], "types": ["T043"], "definition": "Meiosis Induction involves the initiation of activities involved in the special method of cell division, occurring in maturation of the germ cells, by which each daughter nucleus receives half the number of chromosomes characteristic of the somatic cells of the species.", "canonical_name": "upregulation of meiosis"}
{"concept_id": "C1513088", "aliases": ["negative regulation of meiosis", "negative regulation of meiotic nuclear division", "downregulation of meiosis", "inhibition of meiosis", "down regulation of meiosis"], "types": ["T043"], "definition": "Meiosis Inhibition involves interference with, or restraint of, the activities involved in the special method of cell division, occurring in maturation of the germ cells, by which each daughter nucleus receives half the number of chromosomes characteristic of the somatic cells of the species.", "canonical_name": "down-regulation of meiosis"}
{"concept_id": "C1513284", "aliases": ["negative regulation of microtubule polymerization", "downregulation of microtubule polymerization", "down-regulation of microtubule polymerization"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. [GOC:mah]", "canonical_name": "down regulation of microtubule polymerization"}
{"concept_id": "C1513285", "aliases": ["down regulation of microtubule depolymerization", "negative regulation of microtubule depolymerization", "downregulation of microtubule depolymerization", "down-regulation of microtubule depolymerization", "negative regulation of microtubule catastrophe", "negative regulation of microtubule disassembly"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. [GOC:mah, ISBN:0815316194]", "canonical_name": "microtubule stabilization"}
{"concept_id": "C1513351", "aliases": ["positive regulation of mitosis", "upregulation of mitosis", "up regulation of mitosis", "up-regulation of mitosis"], "types": ["T043"], "definition": "Mitosis Induction involves the initiation of activities involved in division of the eukaryotic cell nucleus to produce two daughter nuclei that contain the same chromosome and DNA content as that of the parent cell.", "canonical_name": "positive regulation of mitotic nuclear division"}
{"concept_id": "C1513352", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitosis"}
{"concept_id": "C1513788", "aliases": ["apoptosis of myeloid cells", "myeloid cell apoptosis"], "types": ["T043"], "definition": "Any apoptotic process occurring in a neutrophil, eosinophil or basophil.", "canonical_name": "myeloid cell apoptotic process"}
{"concept_id": "C1513789", "aliases": ["down regulation of myeloid cell apoptosis", "down-regulation of myeloid cell apoptosis", "downregulation of myeloid cell apoptosis"], "types": ["T043"], "definition": "Any process that decreases the frequency, rate or extent of apoptosis in neutrophils, eosinophils or basophils.", "canonical_name": "negative regulation of myeloid cell apoptotic process"}
{"concept_id": "C1514472", "aliases": [], "types": ["T039"], "definition": "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta. [GOC:jl, ISBN:0395825172]", "canonical_name": "progesterone secretion"}
{"concept_id": "C1514501", "aliases": ["prostaglandin catabolism", "prostaglandin catabolic process", "prostaglandin breakdown"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of prostaglandin. [GO_REF:0000068, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25290914]", "canonical_name": "prostaglandin degradation"}
{"concept_id": "C1514525", "aliases": [], "types": ["T044"], "definition": "Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation. [GOC:mah]", "canonical_name": "proteasome binding"}
{"concept_id": "C1514632", "aliases": ["quinone metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving quinone. [GOC:go_curators, GOC:pr, GOC:TermGenie]", "canonical_name": "quinone metabolic process"}
{"concept_id": "C1514664", "aliases": [], "types": ["T045"], "definition": "The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure. [GOC:mah, PMID:10393192]", "canonical_name": "RNA folding"}
{"concept_id": "C1514672", "aliases": [], "types": ["T045"], "definition": "RNA Synthesis Inhibition involves interference with, or restraint of, the activities involved in the polymeric linkage of ribose purine and pyrimidine nucleotides together by phosphate groups attached to their 5-prime and 3-prime sugar hydroxyls.", "canonical_name": "inhibition of RNA synthesis"}
{"concept_id": "C1514825", "aliases": ["regulation of peptidolysis"], "types": ["T044"], "definition": "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:mah]", "canonical_name": "regulation of proteolysis"}
{"concept_id": "C1514916", "aliases": [], "types": ["T044"], "definition": "Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. [GOC:hjd]", "canonical_name": "retinoic acid binding"}
{"concept_id": "C1514925", "aliases": ["Class I transposition", "retrotransposition", "transposition, RNA-mediated", "RNA-mediated transposition"], "types": ["T045"], "definition": "Any process involved in a type of transpositional recombination which occurs via an RNA intermediate. [GOC:jp, ISBN:1555812090]", "canonical_name": "retrotransposon transposition"}
{"concept_id": "C1514932", "aliases": [], "types": ["T045"], "definition": "Reverse Transcription Inhibition involves interference with, or restraint of, activities involved in copying RNA into DNA by reverse transcriptase.", "canonical_name": "inhibition of reverse transcription"}
{"concept_id": "C1514964", "aliases": [], "types": ["T043"], "definition": "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [CL:0000034, GOC:isa_complete]", "canonical_name": "stem cell differentiation"}
{"concept_id": "C1515126", "aliases": [], "types": ["T043"], "definition": "Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction. Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells. (NCI/OSP)", "canonical_name": "T cell development"}
{"concept_id": "C1515331", "aliases": [], "types": ["T042"], "definition": "Testosterone Secretion Induction consists of initiation of activities involved in release into the bloodstream by testicular interstitial (Leydig's) cells of the major androgenic steroid hormone (testosterone) produced in response to adenohypophyseal luteinizing hormone that regulates gonadotropic secretion; Wolffian duct differentiation into epididymis, vas deferens, and seminal vesicle; spermatogenesis after peripheral conversion to dihydrotestosterone by 5a-reductase; and skeletal muscle and bone tissue. Alteration of positive or negative feedback mechanisms can affect hormone release.", "canonical_name": "testosterone secretion"}
{"concept_id": "C1515432", "aliases": ["T cell differentiation in thymus", "thymocyte differentiation", "thymic T cell differentiation"], "types": ["T043"], "definition": "The progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery.", "canonical_name": "thymocyte cell differentiation"}
{"concept_id": "C1515433", "aliases": ["thymic T lymphocyte selection", "thymic T cell selection", "thymic T-lymphocyte selection"], "types": ["T043"], "definition": "The process of T cell selection that occurs in the thymus. [ISBN:0781735149, PMID:12414722]", "canonical_name": "thymic T-cell selection"}
{"concept_id": "C1516010", "aliases": [], "types": ["T044"], "definition": "Binding to a vasopressin receptor. [GOC:mah, GOC:nln]", "canonical_name": "vasopressin receptor binding"}
{"concept_id": "C1516294", "aliases": ["cardiac muscle contraction"], "types": ["T042"], "definition": "Muscle contraction of cardiac muscle tissue. [GOC:dph]", "canonical_name": "heart muscle contraction"}
{"concept_id": "C1516323", "aliases": ["down regulation of cell-cell adhesion", "negative regulation of cell-cell adhesion", "downregulation of cell-cell adhesion", "down-regulation of cell-cell adhesion"], "types": ["T043"], "definition": "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. [GOC:isa_complete]", "canonical_name": "inhibition of cell-cell adhesion"}
{"concept_id": "C1516324", "aliases": ["inhibition of cell-matrix adhesion", "down-regulation of cell-matrix adhesion", "downregulation of cell-matrix adhesion", "down regulation of cell-matrix adhesion"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix. [GOC:hjd]", "canonical_name": "negative regulation of cell-matrix adhesion"}
{"concept_id": "C1516326", "aliases": [], "types": ["T043"], "definition": "Any cellular process that reduces the frequency, rate or extent of cell adhesion.", "canonical_name": "inhibition of cell adhesion"}
{"concept_id": "C1516332", "aliases": ["down regulation of progression through cell cycle", "negative regulation of cell cycle progression", "negative regulation of progression through cell cycle", "downregulation of progression through cell cycle", "down-regulation of progression through cell cycle"], "types": ["T043"], "definition": "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]", "canonical_name": "negative regulation of cell cycle"}
{"concept_id": "C1516337", "aliases": [], "types": ["T043"], "definition": "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. [GOC:mtg_cell_cycle]", "canonical_name": "cell cycle phase"}
{"concept_id": "C1516338", "aliases": [], "types": ["T043"], "definition": "Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. [GOC:dph, GOC:tb]", "canonical_name": "positive regulation of cell death"}
{"concept_id": "C1516339", "aliases": ["negative regulation of necroptotic process", "negative regulation of cell death", "negative regulation of necroptosis"], "types": ["T043"], "definition": "Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. [GOC:BHF, GOC:dph, GOC:tb]", "canonical_name": "negative regulation of necrotic cell death"}
{"concept_id": "C1516343", "aliases": ["up regulation of cell differentiation", "up-regulation of cell differentiation", "upregulation of cell differentiation"], "types": ["T043"], "definition": "Any process that activates or increases the frequency, rate or extent of cell differentiation. [GOC:go_curators]", "canonical_name": "positive regulation of cell differentiation"}
{"concept_id": "C1516344", "aliases": ["down-regulation of cell differentiation", "down regulation of cell differentiation", "negative regulation of cell differentiation", "inhibition of cell differentiation"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. [GOC:go_curators]", "canonical_name": "downregulation of cell differentiation"}
{"concept_id": "C1516349", "aliases": [], "types": ["T043"], "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. [GOC:go_curators]", "canonical_name": "cell maturation"}
{"concept_id": "C1516374", "aliases": [], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mah]", "canonical_name": "cellular response to stress"}
{"concept_id": "C1516467", "aliases": [], "types": ["T043"], "definition": "Chemotaxis Inhibition involves interference with, or restraint of, characteristic movement or orientation of an organism or cell along a chemical concentration gradient either toward or away from the chemical stimulus.", "canonical_name": "inhibition of chemotaxis"}
{"concept_id": "C1516543", "aliases": [], "types": ["T043"], "definition": "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]", "canonical_name": "mitotic sister chromatid cohesion"}
{"concept_id": "C1516743", "aliases": [], "types": ["T043"], "definition": "Cell killing caused by the membrane attack complex formed following complement activation. [GOC:add, GOC:rv]", "canonical_name": "complement-dependent cytotoxicity"}
{"concept_id": "C1516746", "aliases": ["negative regulation of complement cascade", "downregulation of complement activation", "negative regulation of complement activation", "down regulation of complement activation"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation. [GOC:go_curators]", "canonical_name": "down-regulation of complement activation"}
{"concept_id": "C1516851", "aliases": [], "types": ["T043"], "definition": "Endocytosis Inhibition involves interference with, or restraint of, cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles by invagination of the plasma membrane.", "canonical_name": "inhibition of endocytosis"}
{"concept_id": "C1516926", "aliases": [], "types": ["T039"], "definition": "Epinephrine Secretion Inhibition consists of interference with, or restraint of, activities involved in release across the cell membrane into the bloodstream from the adrenal medulla of a sympathomimetic hormone (epinephrine) that stimulates the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. Alteration of positive or negative feedback mechanisms can affect hormone release.", "canonical_name": "inhibition of epinephrine secretion"}
{"concept_id": "C1516975", "aliases": ["estrogen secretion"], "types": ["T042"], "definition": "Estrogen Secretion Induction consists of the initiation of activities involved in release into the bloodstream by the ovaries of a class of steroid substances (estrogens) that have a specific regulatory effect on the activity of cells involved in development and maintenance of secondary female sex characteristics and control of the cyclical changes in the reproductive cycle, as well as pregnancy maintenance and an anabolic effect on protein metabolism and water retention. Alteration of positive or negative feedback mechanisms can affect hormone release.", "canonical_name": "oestrogen secretion"}
{"concept_id": "C1516988", "aliases": [], "types": ["T026"], "definition": "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. [GOC:dph, GOC:ef]", "canonical_name": "excitatory synapse"}
{"concept_id": "C1516997", "aliases": [], "types": ["T043"], "definition": "Exocytosis Inhibition involves interference with, or restraint of, the cellular release of secretory products granules.", "canonical_name": "inhibition of exocytosis"}
{"concept_id": "C1517080", "aliases": [], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. [GOC:jid, GOC:jl]", "canonical_name": "eye development"}
{"concept_id": "C1517338", "aliases": ["maintenance of G0 arrest", "maintenance of G0 phase", "maintenance of cell quiescence", "negative regulation of G0 to G1 transition"], "types": ["T043"], "definition": "A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase. [GOC:mah]", "canonical_name": "maintenance of cell cycle quiescence"}
{"concept_id": "C1517340", "aliases": ["G1/S transition checkpoint"], "types": ["T043"], "definition": "The point in G1 at which cells become committed to enter S phase and initiate DNA replication.", "canonical_name": "G1/S checkpoint"}
{"concept_id": "C1517349", "aliases": ["gamma-aminobutyric acid receptor binding", "4-aminobutanoate receptor binding", "4-aminobutyrate receptor binding"], "types": ["T044"], "definition": "Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. [GOC:ai]", "canonical_name": "GABA receptor binding"}
{"concept_id": "C1517369", "aliases": ["G-protein coupled receptor protein signaling pathway", "GPCR signalling pathway", "G-protein coupled receptor signalling pathway", "G protein coupled receptor protein signaling pathway", "G protein coupled receptor protein signalling pathway", "G-protein coupled receptor protein signal transduction", "GPCR signaling pathway", "G protein-coupled receptor signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]", "canonical_name": "G-protein-coupled receptor protein signalling pathway"}
{"concept_id": "C1517553", "aliases": ["glia proliferation"], "types": ["T043"], "definition": "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. [GOC:ef, ISBN:0878932585]", "canonical_name": "glial cell proliferation"}
{"concept_id": "C1517596", "aliases": ["ionophore activity"], "types": ["T044"], "definition": "Any cellular process involved in the translocation of charged macromolecules, solutes and solvents into or out of a cell.", "canonical_name": "ionophore"}
{"concept_id": "C1517825", "aliases": ["leukotriene breakdown", "leukotriene catabolism", "leukotriene degradation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:yaf]", "canonical_name": "leukotriene catabolic process"}
{"concept_id": "C1517827", "aliases": [], "types": ["T044"], "definition": "Binding to a leukotriene receptor. [GOC:mah, GOC:nln]", "canonical_name": "leukotriene receptor binding"}
{"concept_id": "C1517884", "aliases": ["limb development"], "types": ["T042"], "definition": "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. [GOC:dgh, GOC:dph, PMID:11487378]", "canonical_name": "paired limb/fin development"}
{"concept_id": "C1518060", "aliases": ["lymphocyte apoptosis"], "types": ["T043"], "definition": "Any apoptotic process occurring in a B cell, T cell or natural killer cell.", "canonical_name": "lymphocyte apoptotic process"}
{"concept_id": "C1518061", "aliases": ["downregulation of lymphocyte apoptosis", "down-regulation of lymphocyte apoptosis", "down regulation of lymphocyte apoptosis"], "types": ["T043"], "definition": "Any process that decreases the frequency, rate or extent of apoptosis in B cells, T cells or natural killer cells.", "canonical_name": "negative regulation of lymphocyte apoptotic process"}
{"concept_id": "C1518065", "aliases": ["down regulation of lymphocyte activation", "downregulation of lymphocyte activation", "negative regulation of lymphocyte activation"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. [GOC:ai]", "canonical_name": "down-regulation of lymphocyte activation"}
{"concept_id": "C1518147", "aliases": ["down regulation of mitosis", "downregulation of mitosis", "negative regulation of mitotic nuclear division", "negative regulation of mitosis"], "types": ["T043"], "definition": "A process that consists of interference with, or restraint of, activities that regulate the cellular capacity to transit the last cell cycle stage during which replicated daughter chromosomes separate into separate nuclei and cytokinesis occurs to produce separate daughter cells.", "canonical_name": "down-regulation of mitosis"}
{"concept_id": "C1518158", "aliases": ["malate:aspartate shuttle", "malate/aspartate shuttle", "malate-aspartate shuttle"], "types": ["T044"], "definition": "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle. [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]", "canonical_name": "malate aspartate shuttle"}
{"concept_id": "C1518387", "aliases": ["non-stop decay", "nuclear-transcribed mRNA breakdown, non-stop decay", "non-stop mRNA decay", "nuclear-transcribed mRNA catabolism, non-stop decay", "nuclear-transcribed mRNA catabolic process, non-stop decay", "nonstop mRNA decay"], "types": ["T045"], "definition": "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon. [PMID:11910110]", "canonical_name": "nuclear-transcribed mRNA degradation, non-stop decay"}
{"concept_id": "C1518406", "aliases": ["double-strand break repair via nonhomologous end joining"], "types": ["T045"], "definition": "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. [GOC:rph, PMID:10827453, PMID:24837021]", "canonical_name": "NHEJ"}
{"concept_id": "C1518433", "aliases": [], "types": ["T043"], "definition": "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. [GOC:ai]", "canonical_name": "regulation of nuclear division"}
{"concept_id": "C1518451", "aliases": [], "types": ["T026"], "definition": "A thread-like complex of ribosomal components including ribosomal RNA, in various stages of transcription, and associated proteins.", "canonical_name": "pars fibrosa"}
{"concept_id": "C1518452", "aliases": [], "types": ["T026"], "definition": "A collection of preribosomes in the nucleolus.", "canonical_name": "pars granulosa"}
{"concept_id": "C1518587", "aliases": [], "types": ["T026"], "definition": "The cytoplasm of an ovum. [PMID:19022436]", "canonical_name": "ooplasm"}
{"concept_id": "C1518591", "aliases": [], "types": ["T044"], "definition": "Binding to an opioid receptor. [GOC:nln]", "canonical_name": "opioid receptor binding"}
{"concept_id": "C1518774", "aliases": [], "types": ["T026"], "definition": "Ubiquitinated proteins are degraded by a 26S ATP-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules. The multi-subunit PA700 complex binds two sites of the 20S proteasome and is composed of at least six related ATPases and approximately fifteen non-ATPase polypeptides. Each of the ATPases, PSMC1-6, contains an AAA (ATPases associated with diverse cellular activities) domain. A protein complex containing p42 and p50 enhances PA700 activation of the proteasome.", "canonical_name": "19S regulatory particle"}
{"concept_id": "C1518892", "aliases": [], "types": ["T044"], "definition": "Binding to a parathyroid hormone receptor. [GOC:mah, GOC:nln]", "canonical_name": "parathyroid hormone receptor binding"}
{"concept_id": "C1519017", "aliases": [], "types": ["T029"], "definition": "The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane). [GOC:dos]", "canonical_name": "perivitelline space"}
{"concept_id": "C1519020", "aliases": ["peroxisome proliferation", "peroxisome division"], "types": ["T043"], "definition": "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. [GOC:mah, PMID:11687502, PMID:14754507]", "canonical_name": "peroxisome fission"}
{"concept_id": "C1519027", "aliases": [], "types": ["T043"], "definition": "Phagocytosis Inhibition involves interference with, or restraint of, the process of endocytosis of particulate material by phagocytes, such as microorganisms or cellular fragments and debris, into membranous phagosomes that fuse with lysosmes and result in digestion of the ingested material; an important defense against infection. (NCI)", "canonical_name": "inhibition of phagocytosis"}
{"concept_id": "C1519062", "aliases": [], "types": ["T044"], "definition": "Phosphorylation Inhibition involves interference with, or restraint of, the enzymatic creation of a phosphate derivative of an organic molecule; often by transfer of a phosphate group from ATP via the action of a kinase.", "canonical_name": "inhibition of phosphorylation"}
{"concept_id": "C1519257", "aliases": [], "types": ["T043"], "definition": "Any process in which the monoamine neurotransmitter serotonin is released or retained in the synaptic cleft, resulting in induced or sustained neurotransmission. Serotonin release can be upregulated in the presence of the empathogen MDMA. Monoamine oxidase inhibitors similarly increase steady state levels of serotonin in the brain by reducing its degradation within synapses. This process is involved in numerous functions, including regulation of mood, appetite, sleep, muscle contraction, and some cognitive functions including memory and learning.", "canonical_name": "positive regulation of serotonin release"}
{"concept_id": "C1519259", "aliases": ["serotonin degradation", "serotonin catabolism", "serotonin catabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:jl, ISBN:0198506732]", "canonical_name": "serotonin breakdown"}
{"concept_id": "C1519312", "aliases": [], "types": ["T043"], "definition": "Any feature of a cellular signaling process which negatively regulates the further transduction of cell signaling.", "canonical_name": "inhibition of signal transduction"}
{"concept_id": "C1519473", "aliases": [], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. [GOC:add, ISBN:0781735149]", "canonical_name": "spleen development"}
{"concept_id": "C1519613", "aliases": ["biopolymerisation", "translation initiation", "translational initiation"], "types": ["T045"], "definition": "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [ISBN:019879276X]", "canonical_name": "biopolymerization"}
{"concept_id": "C1519624", "aliases": ["membrane transport"], "types": ["T043"], "definition": "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]", "canonical_name": "transmembrane transport"}
{"concept_id": "C1519751", "aliases": ["protein ubiquitinylation", "protein ubiquitylation"], "types": ["T044"], "definition": "The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]", "canonical_name": "protein ubiquitination"}
{"concept_id": "C1519877", "aliases": ["V-D-J recombination", "V-J joining", "V-J recombination", "V(D)J recombination", "V-D-J joining"], "types": ["T045"], "definition": "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). [GOC:add, ISBN:0781700221, ISBN:0781735149]", "canonical_name": "V(D)J joining"}
{"concept_id": "C1519906", "aliases": ["protein targeting to vacuole", "protein vacuolar targeting", "vacuolar protein sorting", "protein-vacuole targeting"], "types": ["T044"], "definition": "The process of directing proteins towards the vacuole, usually using signals contained within the protein. [GOC:curators]", "canonical_name": "protein-vacuolar targeting"}
{"concept_id": "C1519989", "aliases": [], "types": ["T026"], "definition": "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments. [ISBN:0716731363]", "canonical_name": "type III intermediate filament"}
{"concept_id": "C1520113", "aliases": ["frizzled signalling pathway", "Wingless signaling pathway", "Wg signaling pathway", "Wnt receptor signalling pathway", "Wingless signalling pathway", "frizzled signaling pathway", "Wg signalling pathway", "Wnt receptor signaling pathway"], "types": ["T044"], "definition": "A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.", "canonical_name": "Wnt signaling pathway"}
{"concept_id": "C1521754", "aliases": ["protein acetylation"], "types": ["T044"], "definition": "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]", "canonical_name": "protein amino acid acetylation"}
{"concept_id": "C1522436", "aliases": [], "types": ["T043"], "canonical_name": "resting phase"}
{"concept_id": "C1522608", "aliases": [], "types": ["T026"], "definition": "A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. [GOC:cjm, Wikipedia:Lamellar_granule]", "canonical_name": "alveolar lamellar body"}
{"concept_id": "C1522733", "aliases": ["meiotic spindle organization and biogenesis", "meiotic spindle organisation", "spindle organization during meiosis"], "types": ["T043"], "canonical_name": "meiotic spindle organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle. [GOC:go_curators, GOC:mah]"}
{"concept_id": "C1522734", "aliases": ["4-methylsterol oxidase activity"], "types": ["T044"], "canonical_name": "C-4 methylsterol oxidase activity", "definition": "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O. [PMID:9811880, RHEA:55220]"}
{"concept_id": "C1522735", "aliases": ["Swr1 complex location", "SWR-C"], "types": ["T026"], "canonical_name": "Swr1 complex", "definition": "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820]"}
{"concept_id": "C1522736", "aliases": ["ESCRT I complex"], "types": ["T026"], "definition": "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. [GOC:rb, PMID:12892785, PMID:12900393]", "canonical_name": "ESCRT I complex location"}
{"concept_id": "C1522737", "aliases": ["ESCRT II complex location"], "types": ["T026"], "definition": "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes. [GOC:rb, PMID:12892785, PMID:12900393]", "canonical_name": "ESCRT II complex"}
{"concept_id": "C1522738", "aliases": ["ESCRT III complex"], "types": ["T026"], "definition": "A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission). [PMID:17556548, PMID:22361144, PMID:28242692, PMID:31132588, PMID:32243490, PMID:34449766]", "canonical_name": "ESCRT III complex location"}
{"concept_id": "C1522740", "aliases": ["Ctf19p-Okp1p-Mcm1p-Ame1p complex location", "COMA complex location", "Ctf19p-Okp1p-Mcm1p-Ame1p complex"], "types": ["T026"], "canonical_name": "COMA complex", "definition": "A kinetochore multiprotein complex that bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. In yeast, consists of Ctf19p, Okp1p, Mcm21p, and Ame1p. [GOC:se, PMID:14633972]"}
{"concept_id": "C1522741", "aliases": ["MIND complex location", "nuclear MIS12/MIND complex location", "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex", "MIND complex", "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex location"], "types": ["T026"], "canonical_name": "nuclear MIS12/MIND complex", "definition": "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1. [GOC:krc, GOC:se, PMID:14633972]"}
{"concept_id": "C1522742", "aliases": [], "types": ["T045"], "canonical_name": "sister chromatid segregation", "definition": "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. [GOC:ai, GOC:elh]"}
{"concept_id": "C1522746", "aliases": [], "types": ["T044"], "canonical_name": "glycerophosphodiester transmembrane transporter activity", "definition": "Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. [GOC:mcc, PMID:12912892]"}
{"concept_id": "C1522747", "aliases": [], "types": ["T043"], "canonical_name": "glycerophosphodiester transmembrane transport", "definition": "The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. [GOC:mcc, PMID:12912892]"}
{"concept_id": "C1522748", "aliases": [], "types": ["T043"], "canonical_name": "guanine nucleotide transport", "definition": "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mcc]"}
{"concept_id": "C1522749", "aliases": [], "types": ["T044"], "canonical_name": "guanine nucleotide transmembrane transporter activity", "definition": "Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other. [GOC:mcc]"}
{"concept_id": "C1522751", "aliases": [], "types": ["T026"], "canonical_name": "hyphal tip", "definition": "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation. [GOC:mcc]"}
{"concept_id": "C1522752", "aliases": [], "types": ["T043"], "canonical_name": "exocyst assembly", "definition": "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex. [GOC:hjd, PMID:9700152, Wikipedia:Exocyst]"}
{"concept_id": "C1522753", "aliases": [], "types": ["T043"], "canonical_name": "regulation of exocyst assembly", "definition": "Any process that modulates the frequency, rate or extent of exocyst assembly. [GOC:hjd]"}
{"concept_id": "C1522754", "aliases": ["down regulation of exocyst assembly", "down-regulation of exocyst assembly", "downregulation of exocyst assembly"], "types": ["T043"], "canonical_name": "negative regulation of exocyst assembly", "definition": "Any process that stops, prevents, or reduces the rate or extent of exocyst assembly. [GOC:hjd]"}
{"concept_id": "C1522755", "aliases": ["up-regulation of exocyst assembly", "up regulation of exocyst assembly", "upregulation of exocyst assembly"], "types": ["T043"], "canonical_name": "positive regulation of exocyst assembly", "definition": "Any process that increases the rate or extent of exocyst assembly. [GOC:hjd]"}
{"concept_id": "C1522756", "aliases": ["regulation of protein amino acid phosphorylation"], "types": ["T044"], "canonical_name": "regulation of protein phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. [GOC:hjd]"}
{"concept_id": "C1522762", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication, synthesis of RNA primer", "definition": "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. [PMID:11395402]"}
{"concept_id": "C1522763", "aliases": ["nitrogen compound metabolism"], "types": ["T040"], "canonical_name": "nitrogen compound metabolic process", "definition": "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1522764", "aliases": ["recognition of phagocytosed substance by phagocytic cell"], "types": ["T043"], "canonical_name": "phagocytosis, recognition", "definition": "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. [GOC:curators, ISBN:0781735149]"}
{"concept_id": "C1522765", "aliases": ["spindle organization and biogenesis", "spindle organisation"], "types": ["T043"], "canonical_name": "spindle organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. [GOC:go_curators, GOC:mah]"}
{"concept_id": "C1522766", "aliases": ["mitotic spindle organization and biogenesis", "mitotic spindle organisation", "spindle organization and biogenesis during mitosis"], "types": ["T043"], "canonical_name": "mitotic spindle organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. [GOC:go_curators, GOC:mah]"}
{"concept_id": "C1522774", "aliases": [], "types": ["T042"], "canonical_name": "progression of morphogenetic furrow during compound eye morphogenesis"}
{"concept_id": "C1522779", "aliases": [], "types": ["T042"], "canonical_name": "epidermis development", "definition": "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. [GOC:go_curators, UBERON:0001003]"}
{"concept_id": "C1522780", "aliases": [], "types": ["T043"], "canonical_name": "mystery cell differentiation", "definition": "The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster. [ISBN:0632030488, PMID:1295747]"}
{"concept_id": "C1522781", "aliases": ["MECP synthase activity", "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)", "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)", "MECDP-synthase activity"], "types": ["T044"], "canonical_name": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity", "definition": "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP. [EC:4.6.1.12, RHEA:23864]"}
{"concept_id": "C1522782", "aliases": ["chloroplast ribulose bisphosphate carboxylase complex location", "chloroplast RubisCO complex", "chloroplast RubisCO complex location"], "types": ["T026"], "canonical_name": "chloroplast ribulose bisphosphate carboxylase complex", "definition": "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana. [GOC:mlg, GOC:mtg_sensu]"}
{"concept_id": "C1522786", "aliases": [], "types": ["T040"], "definition": "The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion. [GOC:tb, PMID:10973091]", "canonical_name": "pollination"}
{"concept_id": "C1522787", "aliases": [], "types": ["T044"], "canonical_name": "amino-terminal vacuolar sorting propeptide binding", "definition": "Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles. [GOC:sm, PMID:10871276]"}
{"concept_id": "C1522788", "aliases": [], "types": ["T044"], "canonical_name": "IAA-Phe conjugate hydrolase activity", "definition": "Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine. [GOC:syr]"}
{"concept_id": "C1522789", "aliases": [], "types": ["T044"], "canonical_name": "IAA-Leu conjugate hydrolase activity", "definition": "Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine. [MetaCyc:RXN-2982]"}
{"concept_id": "C1522790", "aliases": ["response to ionizing radiation stimulus", "response to ionising radiation"], "types": ["T040"], "canonical_name": "response to ionizing radiation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. [PMID:12509526]"}
{"concept_id": "C1522791", "aliases": ["light-independent DNA repair"], "types": ["T045"], "canonical_name": "non-photoreactive DNA repair", "definition": "A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated. [GOC:syr]"}
{"concept_id": "C1522792", "aliases": [], "types": ["T039"], "canonical_name": "seed coat development", "definition": "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1522793", "aliases": ["cellulose microfibril organisation"], "types": ["T043"], "canonical_name": "cellulose microfibril organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall. [GOC:mah, PMID:12468730]"}
{"concept_id": "C1522794", "aliases": [], "types": ["T045"], "canonical_name": "maintenance of DNA methylation", "definition": "Any process involved in maintaining the methylation state of a nucleotide sequence. [PMID:11898023]"}
{"concept_id": "C1522795", "aliases": ["aluminum ion homeostasis"], "types": ["T043"], "definition": "Any process involved in the maintenance of an internal steady state of aluminum ions within an organism or cell. [GOC:jid, GOC:lr, GOC:mah]", "canonical_name": "aluminium ion homeostasis"}
{"concept_id": "C1522796", "aliases": ["response to far red light stimulus"], "types": ["T039"], "canonical_name": "response to far red light", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. [GOC:mtg_far_red, GOC:tb]"}
{"concept_id": "C1522797", "aliases": [], "types": ["T040"], "canonical_name": "regulation of vernalization response", "definition": "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures. [GOC:sm]"}
{"concept_id": "C1522798", "aliases": ["up-regulation of vernalization response", "up regulation of vernalization response", "upregulation of vernalization response"], "types": ["T040"], "canonical_name": "positive regulation of vernalization response", "definition": "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures. [GOC:sm]"}
{"concept_id": "C1522799", "aliases": ["down-regulation of vernalization response", "down regulation of vernalization response", "downregulation of vernalization response"], "types": ["T040"], "canonical_name": "negative regulation of vernalization response", "definition": "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures. [GOC:sm]"}
{"concept_id": "C1522800", "aliases": [], "types": ["T040"], "canonical_name": "stem vascular tissue pattern formation", "definition": "Vascular tissue pattern formation as it occurs in the stem of vascular plants. [GOC:tb]"}
{"concept_id": "C1522801", "aliases": ["axillary shoot system formation"], "types": ["T040"], "canonical_name": "secondary shoot formation", "definition": "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs. [GOC:tb, PMID:12815068]"}
{"concept_id": "C1522802", "aliases": ["response to medium wave ultraviolet radiation stimulus", "response to UVB light stimulus", "response to UVB radiation stimulus", "response to UV-B light stimulus", "response to medium wave ultraviolet light stimulus", "response to UV-B radiation stimulus"], "types": ["T040"], "canonical_name": "response to UV-B", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. [GOC:tb]"}
{"concept_id": "C1522803", "aliases": ["response to UV-C light stimulus", "response to UV-C radiation stimulus", "response to shortwave ultraviolet radiation stimulus", "response to UVC radiation stimulus", "response to shortwave ultraviolet light stimulus", "response to UVC light stimulus", "response to germicidal ultraviolet light stimulus", "response to germicidal ultraviolet radiation stimulus"], "types": ["T040"], "canonical_name": "response to UV-C", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. [GOC:tb]"}
{"concept_id": "C1522804", "aliases": [], "types": ["T040"], "canonical_name": "response to lithium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. [GOC:tb]"}
{"concept_id": "C1522805", "aliases": [], "types": ["T040"], "canonical_name": "floral organ abscission", "definition": "The controlled shedding of floral organs. [GOC:PO_curators, PMID:12972671, PO:0025395]"}
{"concept_id": "C1522807", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle docking during exocytosis"}
{"concept_id": "C1522808", "aliases": [], "types": ["T043"], "canonical_name": "second mitotic wave during compound eye morphogenesis"}
{"concept_id": "C1522809", "aliases": ["intein"], "types": ["T044"], "definition": "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. [GOC:ma, http://www.neb.com/neb/inteins.html]", "canonical_name": "intein-mediated protein splicing"}
{"concept_id": "C1522810", "aliases": ["Isw1 complex location"], "types": ["T026"], "canonical_name": "Isw1 complex", "definition": "A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure. [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]"}
{"concept_id": "C1522811", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]"}
{"concept_id": "C1522812", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen. [GOC:jl]"}
{"concept_id": "C1522814", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine", "definition": "The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine. [RESID:AA0215]"}
{"concept_id": "C1522818", "aliases": ["regulation of epidermal development"], "types": ["T042"], "canonical_name": "regulation of epidermis development", "definition": "Any process that modulates the frequency, rate or extent of epidermis development. [GOC:go_curators]"}
{"concept_id": "C1522819", "aliases": ["negative regulation of epidermal development", "down regulation of epidermis development", "downregulation of epidermis development", "down-regulation of epidermis development"], "types": ["T042"], "canonical_name": "negative regulation of epidermis development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. [GOC:go_curators]"}
{"concept_id": "C1522820", "aliases": ["upregulation of epidermis development", "up-regulation of epidermis development", "up regulation of epidermis development", "positive regulation of epidermal development"], "types": ["T042"], "canonical_name": "positive regulation of epidermis development", "definition": "Any process that activates or increases the frequency, rate or extent of epidermis development. [GOC:go_curators]"}
{"concept_id": "C1522821", "aliases": ["pH reduction"], "types": ["T043"], "definition": "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. [GOC:go_curators]", "canonical_name": "acidification"}
{"concept_id": "C1522822", "aliases": [], "types": ["T043"], "canonical_name": "pH elevation", "definition": "Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. [GOC:go_curators]"}
{"concept_id": "C1522823", "aliases": ["negative regulation of hedgehog signaling pathway", "downregulation of smoothened signaling pathway", "negative regulation of smoothened signalling pathway", "down regulation of smoothened signaling pathway", "negative regulation of hh signaling pathway", "down-regulation of smoothened signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of smoothened signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. [GOC:go_curators]"}
{"concept_id": "C1522824", "aliases": ["positive regulation of smoothened signalling pathway", "up-regulation of smoothened signaling pathway", "upregulation of smoothened signaling pathway", "up regulation of smoothened signaling pathway", "positive regulation of hh signaling pathway", "positive regulation of hedgehog signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of smoothened signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of smoothened signaling. [GOC:go_curators]"}
{"concept_id": "C1522827", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic centrosome separation", "definition": "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis. [GOC:ai]"}
{"concept_id": "C1522828", "aliases": ["downregulation of mitotic centrosome separation", "down regulation of mitotic centrosome separation", "down-regulation of mitotic centrosome separation"], "types": ["T043"], "canonical_name": "negative regulation of mitotic centrosome separation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of centrosome separation. [GOC:ai]"}
{"concept_id": "C1522829", "aliases": ["upregulation of mitotic centrosome separation", "up regulation of mitotic centrosome separation", "up-regulation of mitotic centrosome separation"], "types": ["T043"], "canonical_name": "positive regulation of mitotic centrosome separation", "definition": "Any process that activates or increases the frequency, rate or extent of centrosome separation. [GOC:ai]"}
{"concept_id": "C1522835", "aliases": ["response to arsenic"], "types": ["T043"], "canonical_name": "response to arsenic-containing substance", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. [GOC:hjd, ISBN:0721662544]"}
{"concept_id": "C1522836", "aliases": ["SIAT7", "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity", "cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity", "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity", "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity", "(alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity", "CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP. [EC:2.4.99.7, RHEA:53896]", "canonical_name": "ST6GALNAC activity"}
{"concept_id": "C1522840", "aliases": [], "types": ["T043"], "canonical_name": "R1/R6 development", "definition": "The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster. [GOC:jid]"}
{"concept_id": "C1522842", "aliases": [], "types": ["T043"], "canonical_name": "R2/R5 development", "definition": "The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster. [GOC:jid]"}
{"concept_id": "C1522844", "aliases": [], "types": ["T043"], "canonical_name": "R3/R4 development", "definition": "The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster. [GOC:jid]"}
{"concept_id": "C1522846", "aliases": [], "types": ["T042"], "canonical_name": "compound eye pigmentation", "definition": "Establishment of a pattern of pigment in the compound eye. [GOC:jid]"}
{"concept_id": "C1522847", "aliases": [], "types": ["T042"], "canonical_name": "regulation of compound eye pigmentation", "definition": "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye. [GOC:jid]"}
{"concept_id": "C1522848", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of compound eye pigmentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye. [GOC:jid]"}
{"concept_id": "C1522849", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of compound eye pigmentation", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye. [GOC:jid]"}
{"concept_id": "C1522850", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent protein binding", "definition": "Binding to a protein or protein complex in the presence of calcium. [GOC:jid, PMID:10485905]"}
{"concept_id": "C1522851", "aliases": ["ammonia:ferredoxin oxidoreductase activity"], "types": ["T044"], "canonical_name": "ferredoxin-nitrite reductase activity", "definition": "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+. [EC:1.7.7.1, GOC:jid]"}
{"concept_id": "C1522852", "aliases": [], "types": ["T043"], "canonical_name": "organelle inheritance", "definition": "The partitioning of organelles between daughter cells at cell division. [GOC:jid]"}
{"concept_id": "C1522853", "aliases": ["ER inheritance"], "types": ["T043"], "canonical_name": "endoplasmic reticulum inheritance", "definition": "The partitioning of endoplasmic reticulum between daughter cells at cell division. [GOC:jid]"}
{"concept_id": "C1522855", "aliases": ["mitochondrial distribution", "distribution of mitochondria"], "types": ["T043"], "canonical_name": "mitochondrion distribution", "definition": "Any process that establishes the spatial arrangement of mitochondria between and within cells. [GOC:jid]"}
{"concept_id": "C1522856", "aliases": ["mitochondrion positioning within cell", "mitochondria positioning within cell"], "types": ["T043"], "canonical_name": "intracellular distribution of mitochondria", "definition": "Any process that establishes the spatial arrangement of mitochondria within the cell. [GOC:jid]"}
{"concept_id": "C1522857", "aliases": ["Golgi division", "Golgi partitioning"], "types": ["T043"], "canonical_name": "Golgi inheritance", "definition": "The partitioning of Golgi apparatus between daughter cells at cell division. [GOC:jid, PMID:12851069]"}
{"concept_id": "C1522858", "aliases": ["female gametophyte morphogenesis"], "types": ["T040"], "canonical_name": "embryo sac morphogenesis", "definition": "The process in which the anatomical structures of the embryo sac are generated and organized. The embryo sac develops from the megaspore in heterosporous plants. [GOC:jid, GOC:mtg_plant, http://www.bio.uu.nl]"}
{"concept_id": "C1522859", "aliases": ["conidia formation", "conidia biosynthesis"], "types": ["T043"], "canonical_name": "conidium formation", "definition": "The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. [GOC:di, ISBN:0963117211, PMID:2524423, PMID:9529886]"}
{"concept_id": "C1522860", "aliases": [], "types": ["T039"], "canonical_name": "seed development", "definition": "The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves. [GOC:jid, PO:0009010]"}
{"concept_id": "C1522861", "aliases": [], "types": ["T040"], "canonical_name": "seed morphogenesis", "definition": "The process in which the anatomical structures of the seed are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522862", "aliases": [], "types": ["T042"], "canonical_name": "axial mesoderm development", "definition": "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. [GOC:dgh]"}
{"concept_id": "C1522863", "aliases": [], "types": ["T042"], "canonical_name": "axial mesoderm morphogenesis", "definition": "The process in which the anatomical structures of the axial mesoderm are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522864", "aliases": [], "types": ["T042"], "canonical_name": "axial mesoderm formation", "definition": "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:dgh]"}
{"concept_id": "C1522865", "aliases": ["axial mesoderm cell differentiation"], "types": ["T043"], "canonical_name": "axial mesodermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an axial mesoderm cell. [GOC:dgh]"}
{"concept_id": "C1522866", "aliases": ["axial mesoderm cell fate commitment"], "types": ["T043"], "canonical_name": "axial mesodermal cell fate commitment", "definition": "The process in which a cell becomes committed to become an axial mesoderm cell. [GOC:dgh]"}
{"concept_id": "C1522867", "aliases": ["axial mesoderm cell fate determination"], "types": ["T043"], "canonical_name": "axial mesodermal cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:dgh]"}
{"concept_id": "C1522871", "aliases": ["axial mesoderm cell fate specification"], "types": ["T043"], "canonical_name": "axial mesodermal cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:dgh]"}
{"concept_id": "C1522875", "aliases": ["axial mesoderm structural organisation"], "types": ["T042"], "canonical_name": "axial mesoderm structural organization", "definition": "The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure. [GOC:dgh]"}
{"concept_id": "C1522876", "aliases": [], "types": ["T042"], "canonical_name": "mesoderm morphogenesis", "definition": "The process in which the anatomical structures of the mesoderm are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522877", "aliases": ["mesoderm cell differentiation"], "types": ["T043"], "canonical_name": "mesodermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. [GOC:dgh]"}
{"concept_id": "C1522882", "aliases": ["mesoderm structural organisation"], "types": ["T042"], "canonical_name": "mesoderm structural organization", "definition": "The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure. [GOC:dgh]"}
{"concept_id": "C1522883", "aliases": [], "types": ["T042"], "canonical_name": "paraxial mesoderm development", "definition": "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. [GOC:dgh]"}
{"concept_id": "C1522884", "aliases": [], "types": ["T042"], "canonical_name": "paraxial mesoderm morphogenesis", "definition": "The process in which the anatomical structures of the paraxial mesoderm are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522885", "aliases": [], "types": ["T042"], "canonical_name": "paraxial mesoderm formation", "definition": "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:dgh]"}
{"concept_id": "C1522896", "aliases": ["paraxial mesoderm structural organisation"], "types": ["T042"], "canonical_name": "paraxial mesoderm structural organization", "definition": "The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure. [GOC:dgh]"}
{"concept_id": "C1522897", "aliases": [], "types": ["T026"], "canonical_name": "primary endosperm nucleus", "definition": "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac. [ISBN:0471245208]"}
{"concept_id": "C1522898", "aliases": ["mucilage synthesis during seed coat development", "mucilage formation during seed coat development", "mucilage anabolism during seed coat development"], "types": ["T044"], "canonical_name": "mucilage biosynthetic process involved in seed coat development", "definition": "The chemical reactions and pathways resulting in the formation of mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development. [GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1522899", "aliases": ["root cap mucilage formation", "root cap mucilage anabolism", "root cap mucilage biosynthesis", "root cap mucilage synthesis"], "types": ["T044"], "canonical_name": "root cap mucilage biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth. [GOC:jid]"}
{"concept_id": "C1522900", "aliases": ["root epithelial mucilage anabolism", "root epithelial mucilage biosynthesis", "root epithelial mucilage synthesis", "root epithelial mucilage formation"], "types": ["T044"], "canonical_name": "root epithelial mucilage biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth. [GOC:jid]"}
{"concept_id": "C1522901", "aliases": ["pedicel mucilage synthesis", "pedicel mucilage formation", "pedicel mucilage anabolism", "pedicel mucilage biosynthesis"], "types": ["T044"], "canonical_name": "pedicel mucilage biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem. [GOC:jid]"}
{"concept_id": "C1522902", "aliases": ["mucilage pectin anabolism", "mucilage pectin biosynthesis", "mucilage pectin formation", "mucilage pectin synthesis"], "types": ["T044"], "canonical_name": "mucilage pectin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the pectin component of mucilage. [GOC:jid]"}
{"concept_id": "C1522903", "aliases": ["mucilage metabolism during seed coat development"], "types": ["T044"], "canonical_name": "mucilage metabolic process involved in seed coat development", "definition": "The chemical reactions and pathways involving mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development. [GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1522904", "aliases": ["root cap mucilage metabolism"], "types": ["T044"], "canonical_name": "root cap mucilage metabolic process", "definition": "The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth. [GOC:jid]"}
{"concept_id": "C1522905", "aliases": ["root epithelial mucilage metabolism"], "types": ["T044"], "canonical_name": "root epithelial mucilage metabolic process", "definition": "The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth. [GOC:jid]"}
{"concept_id": "C1522906", "aliases": ["pedicel mucilage metabolism"], "types": ["T044"], "canonical_name": "pedicel mucilage metabolic process", "definition": "The chemical reactions and pathways involving mucilage that occur in the flower stem. [GOC:jid]"}
{"concept_id": "C1522907", "aliases": ["mucilage pectin metabolism"], "types": ["T044"], "canonical_name": "mucilage pectin metabolic process", "definition": "The chemical reactions and pathways involving the pectin component of mucilage. [GOC:jid]"}
{"concept_id": "C1522909", "aliases": [], "types": ["T039"], "canonical_name": "leaf development", "definition": "The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1522910", "aliases": ["shoot development"], "types": ["T042"], "canonical_name": "shoot system development", "definition": "The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1522911", "aliases": ["lateral plate mesoderm development"], "types": ["T042"], "canonical_name": "lateral mesoderm development", "definition": "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1522912", "aliases": ["lateral plate mesoderm morphogenesis"], "types": ["T042"], "canonical_name": "lateral mesoderm morphogenesis", "definition": "The process in which the anatomical structures of the lateral mesoderm are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522913", "aliases": ["lateral plate mesoderm biosynthesis", "lateral plate mesoderm formation"], "types": ["T042"], "canonical_name": "lateral mesoderm formation", "definition": "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:jid]"}
{"concept_id": "C1522914", "aliases": ["lateral plate mesodermal cell differentiation", "lateral plate mesoderm cell differentiation", "lateral mesoderm cell differentiation"], "types": ["T043"], "canonical_name": "lateral mesodermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell. [GOC:jid]"}
{"concept_id": "C1522915", "aliases": ["lateral mesoderm cell fate commitment", "lateral plate mesoderm cell fate commitment", "lateral plate mesodermal cell fate commitment"], "types": ["T043"], "canonical_name": "lateral mesodermal cell fate commitment", "definition": "The process in which a cell becomes committed to become a lateral mesoderm cell. [GOC:jid]"}
{"concept_id": "C1522916", "aliases": ["lateral plate mesodermal cell fate determination", "lateral mesoderm cell fate determination", "lateral plate mesoderm cell fate determination"], "types": ["T043"], "canonical_name": "lateral mesodermal cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:jid]"}
{"concept_id": "C1522917", "aliases": ["regulation of lateral plate mesodermal cell fate determination", "regulation of lateral plate mesoderm cell fate determination", "regulation of lateral mesoderm cell fate determination"], "types": ["T043"], "canonical_name": "regulation of lateral mesodermal cell fate determination", "definition": "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination. [GOC:jid]"}
{"concept_id": "C1522920", "aliases": ["lateral plate mesoderm cell fate specification", "lateral plate mesodermal cell fate specification", "lateral mesoderm cell fate specification"], "types": ["T043"], "canonical_name": "lateral mesodermal cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:jid]"}
{"concept_id": "C1522924", "aliases": ["lateral mesoderm structural organisation", "lateral plate mesoderm structural organization"], "types": ["T042"], "canonical_name": "lateral mesoderm structural organization", "definition": "The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure. [GOC:jid]"}
{"concept_id": "C1522925", "aliases": [], "types": ["T042"], "canonical_name": "mesendoderm development", "definition": "The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues. [GOC:jid]"}
{"concept_id": "C1522926", "aliases": [], "types": ["T042"], "canonical_name": "mesectoderm development", "definition": "The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues. [GOC:jid]"}
{"concept_id": "C1522927", "aliases": ["retinoic acid receptor signalling pathway", "RAR signaling pathway"], "types": ["T044"], "canonical_name": "retinoic acid receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh]"}
{"concept_id": "C1522928", "aliases": ["regulation of retinoic acid receptor signalling pathway", "regulation of RAR signaling pathway"], "types": ["T044"], "canonical_name": "regulation of retinoic acid receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. [GOC:dgh]"}
{"concept_id": "C1522929", "aliases": ["up-regulation of retinoic acid receptor signaling pathway", "positive regulation of RAR signaling pathway", "up regulation of retinoic acid receptor signaling pathway", "positive regulation of retinoic acid receptor signalling pathway", "upregulation of retinoic acid receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of retinoic acid receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity. [GOC:dgh]"}
{"concept_id": "C1522930", "aliases": ["downregulation of retinoic acid receptor signaling pathway", "negative regulation of retinoic acid receptor signalling pathway", "negative regulation of RAR signaling pathway", "down regulation of retinoic acid receptor signaling pathway", "down-regulation of retinoic acid receptor signaling pathway", "negative regulation of RAR signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of retinoic acid receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. [GOC:dgh]"}
{"concept_id": "C1522931", "aliases": [], "types": ["T044"], "canonical_name": "endosomal lumen acidification", "definition": "Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion. [GOC:jid]"}
{"concept_id": "C1522932", "aliases": [], "types": ["T042"], "canonical_name": "intermediate mesoderm development", "definition": "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. [GOC:dgh]"}
{"concept_id": "C1522933", "aliases": [], "types": ["T042"], "canonical_name": "intermediate mesoderm morphogenesis", "definition": "The process in which the anatomical structures of the intermediate mesoderm are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522934", "aliases": [], "types": ["T042"], "canonical_name": "intermediate mesoderm formation", "definition": "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:dgh]"}
{"concept_id": "C1522935", "aliases": ["intermediate mesoderm cell differentiation"], "types": ["T043"], "canonical_name": "intermediate mesodermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell. [GOC:dgh]"}
{"concept_id": "C1522936", "aliases": ["intermediate mesoderm cell fate commitment"], "types": ["T043"], "canonical_name": "intermediate mesodermal cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell. [GOC:dgh]"}
{"concept_id": "C1522937", "aliases": ["intermediate mesoderm cell fate determination"], "types": ["T043"], "canonical_name": "intermediate mesodermal cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:dgh]"}
{"concept_id": "C1522941", "aliases": ["intermediate mesoderm cell fate specification"], "types": ["T043"], "canonical_name": "intermediate mesodermal cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:dgh]"}
{"concept_id": "C1522945", "aliases": ["intermediate mesoderm structural organisation"], "types": ["T042"], "canonical_name": "intermediate mesoderm structural organization", "definition": "The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure. [GOC:dgh]"}
{"concept_id": "C1522946", "aliases": ["BDNF binding"], "types": ["T044"], "canonical_name": "brain-derived neurotrophic factor binding", "definition": "Binding to brain-derived neurotrophic factor. [GOC:dgh]"}
{"concept_id": "C1522947", "aliases": ["NT-3 binding", "neurotrophin-3 binding", "NT3 binding"], "types": ["T044"], "canonical_name": "neurotrophin 3 binding"}
{"concept_id": "C1522949", "aliases": ["NGF binding", "beta-nerve growth factor binding"], "types": ["T044"], "canonical_name": "nerve growth factor binding", "definition": "Binding to nerve growth factor (NGF). [GOC:dgh]"}
{"concept_id": "C1522950", "aliases": ["platelet-derived growth factor binding"], "types": ["T044"], "definition": "Binding to platelet-derived growth factor. [GOC:dgh]", "canonical_name": "PDGF binding"}
{"concept_id": "C1522951", "aliases": ["EGF binding"], "types": ["T044"], "canonical_name": "epidermal growth factor binding", "definition": "Binding to epidermal growth factor. [GOC:dgh]"}
{"concept_id": "C1522952", "aliases": [], "types": ["T038"], "canonical_name": "floral organ development", "definition": "The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure. [GOC:go_curators, GOC:PO_curators, PO:0025395]"}
{"concept_id": "C1522953", "aliases": [], "types": ["T038"], "canonical_name": "floral whorl development", "definition": "The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant. [GOC:dph, GOC:go_curators, GOC:PO_curators, GOC:tb, PO:0025023]"}
{"concept_id": "C1522954", "aliases": [], "types": ["T038"], "canonical_name": "flower morphogenesis", "definition": "The process in which the anatomical structures of the flower are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522955", "aliases": [], "types": ["T038"], "canonical_name": "carpel development", "definition": "The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style. [GOC:go_curators]"}
{"concept_id": "C1522956", "aliases": [], "types": ["T038"], "canonical_name": "petal development", "definition": "The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1522957", "aliases": [], "types": ["T038"], "canonical_name": "sepal development", "definition": "The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1522958", "aliases": [], "types": ["T040"], "canonical_name": "stamen development", "definition": "The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1522959", "aliases": [], "types": ["T038"], "canonical_name": "floral organ morphogenesis", "definition": "The process in which the anatomical structures of the floral organ are generated and organized. [GOC:go_curators, GOC:PO_curators, PO:0025395]"}
{"concept_id": "C1522960", "aliases": [], "types": ["T038"], "canonical_name": "carpel morphogenesis", "definition": "The process in which the anatomical structures of the carpel are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522961", "aliases": [], "types": ["T038"], "canonical_name": "petal morphogenesis", "definition": "The process in which the anatomical structures of the petal are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522962", "aliases": [], "types": ["T038"], "canonical_name": "sepal morphogenesis", "definition": "The process in which the anatomical structures of the sepal are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522963", "aliases": [], "types": ["T038"], "canonical_name": "stamen morphogenesis", "definition": "The process in which the anatomical structures of the stamen are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1522964", "aliases": [], "types": ["T038"], "canonical_name": "floral organ formation", "definition": "The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts. [GOC:jid, GOC:PO_curators, PO:0025395]"}
{"concept_id": "C1522965", "aliases": ["floral organ structural organisation"], "types": ["T038"], "canonical_name": "floral organ structural organization", "definition": "The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure. [GOC:jid, GOC:PO_curators, PO:0025395]"}
{"concept_id": "C1522966", "aliases": [], "types": ["T038"], "canonical_name": "petal formation", "definition": "The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts. [GOC:jid]"}
{"concept_id": "C1522967", "aliases": ["petal structural organisation"], "types": ["T038"], "canonical_name": "petal structural organization", "definition": "The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure. [GOC:jid]"}
{"concept_id": "C1522968", "aliases": [], "types": ["T038"], "canonical_name": "sepal formation", "definition": "The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts. [GOC:jid]"}
{"concept_id": "C1522969", "aliases": ["sepal structural organisation"], "types": ["T038"], "canonical_name": "sepal structural organization", "definition": "The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure. [GOC:jid]"}
{"concept_id": "C1522970", "aliases": [], "types": ["T038"], "canonical_name": "stamen formation", "definition": "The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts. [GOC:jid]"}
{"concept_id": "C1522971", "aliases": ["stamen structural organisation"], "types": ["T038"], "canonical_name": "stamen structural organization", "definition": "The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure. [GOC:jid]"}
{"concept_id": "C1522972", "aliases": [], "types": ["T038"], "canonical_name": "floral whorl morphogenesis", "definition": "The process in which the anatomical structures of the floral whorl are generated and organized. [GOC:go_curators, GOC:PO_curators, PO:0025023]"}
{"concept_id": "C1522973", "aliases": [], "types": ["T038"], "canonical_name": "floral whorl formation", "definition": "The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts. [GOC:jid, GOC:PO_curators, PO:0025023]"}
{"concept_id": "C1522974", "aliases": ["floral whorl structural organisation"], "types": ["T038"], "canonical_name": "floral whorl structural organization", "definition": "The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure. [GOC:jid, GOC:PO_curators, PO:0025023]"}
{"concept_id": "C1522975", "aliases": [], "types": ["T038"], "canonical_name": "flower formation", "definition": "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts. [GOC:jid]"}
{"concept_id": "C1522976", "aliases": ["flower structural organisation"], "types": ["T038"], "canonical_name": "flower structural organization", "definition": "The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure. [GOC:jid]"}
{"concept_id": "C1522977", "aliases": [], "types": ["T038"], "canonical_name": "carpel formation", "definition": "The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts. [GOC:jid]"}
{"concept_id": "C1522978", "aliases": ["carpel structural organisation"], "types": ["T038"], "canonical_name": "carpel structural organization", "definition": "The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure. [GOC:jid]"}
{"concept_id": "C1522980", "aliases": [], "types": ["T038"], "canonical_name": "corolla development", "definition": "The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1522981", "aliases": ["pistil development"], "types": ["T038"], "canonical_name": "gynoecium development", "definition": "The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower. [GOC:go_curators, PO:0008062]"}
{"concept_id": "C1522984", "aliases": ["L-threonine-O-3-phosphate decarboxylase activity", "L-threonine O-3-phosphate carboxy-lyase activity", "CobD"], "types": ["T044"], "canonical_name": "threonine-phosphate decarboxylase activity", "definition": "Catalysis of the reaction: O-phospho-L-threonine + H(+) = (R)-1-aminopropan-2-yl phosphate + CO(2). [EC:4.1.1.81, RHEA:11492]"}
{"concept_id": "C1522985", "aliases": [], "types": ["T043"], "canonical_name": "D-methionine transport", "definition": "The directed movement of D-methionine into, out of, within, or between cells. [GOC:mlg, PMID:12169620]"}
{"concept_id": "C1522987", "aliases": [], "types": ["T026"], "canonical_name": "coated membrane", "definition": "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. [GOC:jid]"}
{"concept_id": "C1522988", "aliases": ["Holliday junction resolvase complex location", "resolvasome"], "types": ["T026"], "canonical_name": "Holliday junction resolvase complex", "definition": "An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated. [PMID:11207366, PMID:12374758]"}
{"concept_id": "C1522989", "aliases": ["replication fork stabilization"], "types": ["T043"], "canonical_name": "replication fork maintenance"}
{"concept_id": "C1522990", "aliases": [], "types": ["T038"], "canonical_name": "style development", "definition": "The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma. [GOC:jid, PO:0009074]"}
{"concept_id": "C1522991", "aliases": [], "types": ["T038"], "canonical_name": "stigma development", "definition": "The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky. [GOC:jid, PO:0009073]"}
{"concept_id": "C1522992", "aliases": [], "types": ["T038"], "canonical_name": "plant ovule development", "definition": "The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. [GOC:tb]"}
{"concept_id": "C1522993", "aliases": [], "types": ["T038"], "canonical_name": "plant ovule morphogenesis", "definition": "The process in which the anatomical structures of the ovule are generated and organized. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. [GOC:tb]"}
{"concept_id": "C1522994", "aliases": [], "types": ["T042"], "canonical_name": "autonomic nervous system development", "definition": "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. [FMA:9905, GOC:jid, GOC:sr]"}
{"concept_id": "C1522995", "aliases": [], "types": ["T042"], "canonical_name": "enteric nervous system development", "definition": "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. [FMA:66070, GOC:jid, GOC:sr]"}
{"concept_id": "C1522996", "aliases": [], "types": ["T042"], "canonical_name": "sympathetic nervous system development", "definition": "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. [FMA:9906, GOC:jid, GOC:sr]"}
{"concept_id": "C1522997", "aliases": [], "types": ["T042"], "canonical_name": "parasympathetic nervous system development", "definition": "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. [FMA:9907, GOC:jid, GOC:sr]"}
{"concept_id": "C1522998", "aliases": ["beta tubulin binding"], "types": ["T044"], "canonical_name": "beta-tubulin binding", "definition": "Binding to the microtubule constituent protein beta-tubulin. [GOC:krc]"}
{"concept_id": "C1523000", "aliases": ["retrograde axonal transport of synaptic vesicle"], "types": ["T043"], "canonical_name": "retrograde synaptic vesicle transport", "definition": "The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body. [GOC:jid, GOC:lmg, PMID:24762653]"}
{"concept_id": "C1523001", "aliases": ["plasma membrane ribulose bisphosphate carboxylase complex", "plasma membrane ribulose bisphosphate carboxylase complex location", "plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex location"], "types": ["T026"], "canonical_name": "plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex", "definition": "A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. [GOC:mlg, GOC:mtg_sensu]"}
{"concept_id": "C1523002", "aliases": ["chromatophore ribulose bisphosphate carboxylase complex location"], "types": ["T026"], "canonical_name": "chromatophore ribulose bisphosphate carboxylase complex", "definition": "A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. [GOC:mlg, GOC:mtg_sensu]"}
{"concept_id": "C1523003", "aliases": [], "types": ["T044"], "canonical_name": "Roundabout binding", "definition": "Binding to Roundabout (ROBO) receptor, a transmembrane receptor. [GOC:ecd, PMID:10102268, PMID:10197527]"}
{"concept_id": "C1523004", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of animal organ identity", "definition": "The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tb]"}
{"concept_id": "C1523005", "aliases": [], "types": ["T040"], "canonical_name": "maintenance of floral organ identity", "definition": "The process in which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:PO_curators, GOC:tair_curators, PMID:9090883, PO:0025395]"}
{"concept_id": "C1523006", "aliases": [], "types": ["T040"], "canonical_name": "establishment of petal orientation", "definition": "The process that determines the orientation of petals with reference to the central axis. [GOC:tb, PMID:10572040]"}
{"concept_id": "C1523007", "aliases": ["synaptic vesicle membrane organization and biogenesis", "synaptic vesicle membrane organisation"], "types": ["T043"], "canonical_name": "synaptic vesicle membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle. [GOC:dph, GOC:jl, GOC:mah, PMID:10620806]"}
{"concept_id": "C1523008", "aliases": [], "types": ["T026"], "canonical_name": "signal recognition particle, plasma membrane targeting", "definition": "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane. [GOC:mlg, GOC:mtg_sensu]"}
{"concept_id": "C1523009", "aliases": ["ATP-dependent thiamine transmembrane transporter activity", "thiamine-transporting ATPase activity", "thiamin-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled thiamine transmembrane transporter activity"}
{"concept_id": "C1523010", "aliases": ["glycosylphosphatidylinositol binding"], "types": ["T044"], "canonical_name": "GPI anchor binding", "definition": "Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. [GOC:vw]"}
{"concept_id": "C1523011", "aliases": [], "types": ["T042"], "canonical_name": "regulation of timing of animal organ formation", "definition": "Any process that modulates the rate, frequency or extent of animal organ formation at a consistent predetermined time point during development. [GOC:bf, GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1523012", "aliases": [], "types": ["T038"], "canonical_name": "regulation of timing of cell differentiation", "definition": "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. [GOC:bf, GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1523013", "aliases": [], "types": ["T038"], "canonical_name": "regulation of timing of meristematic phase transition", "definition": "Any process that modulates the rate, frequency or extent of a change in identity of a meristem at a characteristic predetermined time point. [GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1523014", "aliases": [], "types": ["T038"], "canonical_name": "meristem development", "definition": "The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1523015", "aliases": [], "types": ["T038"], "canonical_name": "embryonic meristem development", "definition": "The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1523016", "aliases": [], "types": ["T038"], "canonical_name": "regulation of meristem development", "definition": "Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1523018", "aliases": ["rhythmic process"], "types": ["T039"], "definition": "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. [GOC:jid]", "canonical_name": "rhythm"}
{"concept_id": "C1523019", "aliases": ["circadian rhythm behavior"], "types": ["T040"], "canonical_name": "circadian behavior", "definition": "The specific behavior of an organism that recurs with a regularity of approximately 24 hours. [GOC:bf, GOC:go_curators, GOC:pr]"}
{"concept_id": "C1523021", "aliases": [], "types": ["T042"], "canonical_name": "blood vessel morphogenesis", "definition": "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. [GOC:jid]"}
{"concept_id": "C1523022", "aliases": ["regulation of lipid degradation", "regulation of lipid catabolism", "regulation of lipid breakdown"], "types": ["T044"], "canonical_name": "regulation of lipid catabolic process", "definition": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]"}
{"concept_id": "C1523023", "aliases": ["negative regulation of lipid catabolism", "down-regulation of lipid catabolic process", "negative regulation of lipid degradation", "down regulation of lipid catabolic process", "negative regulation of lipid breakdown", "downregulation of lipid catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of lipid catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]"}
{"concept_id": "C1523024", "aliases": ["positive regulation of lipid catabolism", "positive regulation of lipid breakdown", "upregulation of lipid catabolic process", "positive regulation of lipid degradation", "up regulation of lipid catabolic process", "up-regulation of lipid catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of lipid catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]"}
{"concept_id": "C1523025", "aliases": ["quaternary amine binding"], "types": ["T044"], "canonical_name": "quaternary ammonium group binding", "definition": "Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [GOC:ai]"}
{"concept_id": "C1523026", "aliases": ["positive regulation of NOS activity", "up regulation of nitric-oxide synthase activity", "nitric-oxide synthase activator", "upregulation of nitric-oxide synthase activity", "up-regulation of nitric-oxide synthase activity", "NOS activator"], "types": ["T044"], "canonical_name": "positive regulation of nitric-oxide synthase activity", "definition": "Any process that activates or increases the activity of the enzyme nitric-oxide synthase. [GOC:ai]"}
{"concept_id": "C1523027", "aliases": [], "types": ["T044"], "canonical_name": "ligase activity, forming nitrogen-metal bonds", "definition": "Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.6.-.-, GOC:mah]"}
{"concept_id": "C1523028", "aliases": [], "types": ["T044"], "canonical_name": "ligase activity, forming nitrogen-metal bonds, forming coordination complexes", "definition": "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex. [EC:6.6.1.-]"}
{"concept_id": "C1523029", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lipoprotein lipase activity", "definition": "Any process that modulates the activity of the enzyme lipoprotein lipase. [GOC:ai]"}
{"concept_id": "C1523030", "aliases": ["down-regulation of lipoprotein lipase activity", "downregulation of lipoprotein lipase activity", "down regulation of lipoprotein lipase activity"], "types": ["T044"], "canonical_name": "negative regulation of lipoprotein lipase activity", "definition": "Any process that stops or reduces the activity of the enzyme lipoprotein lipase. [GOC:ai]"}
{"concept_id": "C1523031", "aliases": ["up-regulation of lipoprotein lipase activity", "up regulation of lipoprotein lipase activity", "upregulation of lipoprotein lipase activity"], "types": ["T044"], "canonical_name": "positive regulation of lipoprotein lipase activity", "definition": "Any process that activates or increases the activity of the enzyme lipoprotein lipase. [GOC:ai]"}
{"concept_id": "C1523032", "aliases": ["squalene:hopene cyclase activity", "squalene mutase (cyclizing)"], "types": ["T044"], "canonical_name": "squalene-hopene cyclase activity", "definition": "Catalysis of the reaction: squalene = hop-22(29)-ene. [EC:5.4.99.17]"}
{"concept_id": "C1523033", "aliases": [], "types": ["T044"], "canonical_name": "Hsp27 protein binding", "definition": "Binding to Hsp27 proteins, a lightweight heat shock protein. [GOC:ai]"}
{"concept_id": "C1523034", "aliases": [], "types": ["T044"], "canonical_name": "O-acetylhomoserine sulfhydrylase activity", "definition": "Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate. [MetaCyc:ACETYLHOMOSER-CYS-RXN, RHEA:27822]"}
{"concept_id": "C1523035", "aliases": [], "types": ["T044"], "canonical_name": "microtubule plus-end binding", "definition": "Binding to the plus end of a microtubule. [GOC:ai, PMID:14557818, PMID:14614826]"}
{"concept_id": "C1523036", "aliases": [], "types": ["T044"], "canonical_name": "microtubule minus-end binding", "definition": "Binding to the minus end of a microtubule. [GOC:ai, PMID:14557818, PMID:14614826]"}
{"concept_id": "C1523037", "aliases": ["microtubule translocation"], "types": ["T043"], "canonical_name": "microtubule sliding", "definition": "The movement of one microtubule along another microtubule. [PMID:14557818, PMID:14614826]"}
{"concept_id": "C1523038", "aliases": [], "types": ["T043"], "canonical_name": "microtubule severing", "definition": "The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends. [GOC:ai, PMID:27037673]"}
{"concept_id": "C1523039", "aliases": ["actin filament severing", "F-actin severing", "actin depolymerizing activity"], "types": ["T043"], "definition": "The process in which an actin filament is broken down into smaller filaments. [GOC:ai, PMID:14657234]", "canonical_name": "actin filament severing activity"}
{"concept_id": "C1523040", "aliases": ["F-actin binding"], "types": ["T044"], "canonical_name": "actin filament binding", "definition": "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732]"}
{"concept_id": "C1523041", "aliases": ["actin filament capping", "F-actin capping activity", "plus-end F-actin capping activity", "plus-end actin filament capping activity", "barbed-end actin capping activity", "barbed-end F-actin capping activity", "actin capping activity"], "types": ["T044"], "canonical_name": "barbed-end actin filament capping", "definition": "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. [ISBN:071673706X]"}
{"concept_id": "C1523043", "aliases": ["PKA binding"], "types": ["T044"], "canonical_name": "protein kinase A binding", "definition": "Binding to a protein kinase A. [GOC:ai]"}
{"concept_id": "C1523044", "aliases": ["MAPK binding", "MAP kinase binding"], "types": ["T044"], "canonical_name": "mitogen-activated protein kinase binding", "definition": "Binding to a mitogen-activated protein kinase. [GOC:ai]"}
{"concept_id": "C1523045", "aliases": [], "types": ["T044"], "canonical_name": "GTPase binding", "definition": "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP. [GOC:ai]"}
{"concept_id": "C1523046", "aliases": ["GDI binding"], "types": ["T044"], "canonical_name": "GDP-dissociation inhibitor binding", "definition": "Binding to a GDP-dissociation inhibitor protein. [GOC:ai]"}
{"concept_id": "C1523047", "aliases": ["Rho GDI binding"], "types": ["T044"], "canonical_name": "Rho GDP-dissociation inhibitor binding", "definition": "Binding to a Rho GDP-dissociation inhibitor protein. [GOC:ai]"}
{"concept_id": "C1523048", "aliases": [], "types": ["T043"], "canonical_name": "regulation of immunoglobulin secretion"}
{"concept_id": "C1523052", "aliases": [], "types": ["T043"], "canonical_name": "DNA transport", "definition": "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523053", "aliases": [], "types": ["T043"], "canonical_name": "mRNA transport", "definition": "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523054", "aliases": [], "types": ["T043"], "canonical_name": "rRNA transport", "definition": "The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523055", "aliases": [], "types": ["T043"], "canonical_name": "snRNA transport", "definition": "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523056", "aliases": [], "types": ["T043"], "canonical_name": "tRNA transport", "definition": "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523057", "aliases": [], "types": ["T045"], "canonical_name": "nucleic acid transmembrane transporter activity", "definition": "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information. [GOC:ai]"}
{"concept_id": "C1523058", "aliases": [], "types": ["T045"], "canonical_name": "RNA transmembrane transporter activity", "definition": "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1523059", "aliases": [], "types": ["T045"], "canonical_name": "tRNA transmembrane transporter activity", "definition": "Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1523060", "aliases": [], "types": ["T044"], "canonical_name": "DNA transmembrane transporter activity", "definition": "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1523062", "aliases": ["regulation of transcription, meiotic", "meiotic regulation of transcription"], "types": ["T045"], "canonical_name": "regulation of transcription involved in meiotic cell cycle", "definition": "Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle. [GOC:go_curators]"}
{"concept_id": "C1523063", "aliases": ["negative regulation of transcription, meiotic", "downregulation of transcription during meiosis", "meiotic repression of transcription", "down-regulation of transcription during meiosis", "down regulation of transcription during meiosis", "negative regulation of meiotic transcription"], "types": ["T045"], "canonical_name": "negative regulation of transcription involved in meiotic cell cycle", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle. [GOC:ai]"}
{"concept_id": "C1523064", "aliases": ["up regulation of transcription during meiosis", "upregulation of transcription during meiosis", "up-regulation of transcription during meiosis", "positive regulation of transcription, meiotic", "positive regulation of meiotic transcription"], "types": ["T045"], "canonical_name": "positive regulation of transcription involved in meiotic cell cycle", "definition": "Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle. [GOC:ai]"}
{"concept_id": "C1523065", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium-independent cell-cell adhesion", "definition": "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. [GOC:ai]"}
{"concept_id": "C1523066", "aliases": ["up regulation of calcium-independent cell-cell adhesion", "upregulation of calcium-independent cell-cell adhesion", "up-regulation of calcium-independent cell-cell adhesion"], "types": ["T043"], "canonical_name": "positive regulation of calcium-independent cell-cell adhesion", "definition": "Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion. [GOC:ai]"}
{"concept_id": "C1523067", "aliases": ["downregulation of calcium-independent cell-cell adhesion", "down-regulation of calcium-independent cell-cell adhesion", "down regulation of calcium-independent cell-cell adhesion"], "types": ["T043"], "canonical_name": "negative regulation of calcium-independent cell-cell adhesion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion. [GOC:ai]"}
{"concept_id": "C1523068", "aliases": [], "types": ["T044"], "canonical_name": "regulation of membrane protein ectodomain proteolysis", "definition": "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). [GOC:ai]"}
{"concept_id": "C1523069", "aliases": ["up regulation of membrane protein ectodomain proteolysis", "up-regulation of membrane protein ectodomain proteolysis", "upregulation of membrane protein ectodomain proteolysis"], "types": ["T043"], "canonical_name": "positive regulation of membrane protein ectodomain proteolysis", "definition": "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. [GOC:ai]"}
{"concept_id": "C1523070", "aliases": ["down regulation of membrane protein ectodomain proteolysis", "down-regulation of membrane protein ectodomain proteolysis", "downregulation of membrane protein ectodomain proteolysis"], "types": ["T043"], "canonical_name": "negative regulation of membrane protein ectodomain proteolysis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis. [GOC:ai]"}
{"concept_id": "C1523071", "aliases": [], "types": ["T043"], "canonical_name": "regulation of secretion", "definition": "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1523072", "aliases": ["upregulation of secretion", "up regulation of secretion", "up-regulation of secretion"], "types": ["T043"], "canonical_name": "positive regulation of secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1523073", "aliases": ["downregulation of secretion", "down-regulation of secretion", "down regulation of secretion"], "types": ["T043"], "canonical_name": "negative regulation of secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. [GOC:ai]"}
{"concept_id": "C1523074", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523075", "aliases": ["upregulation of transport", "up regulation of transport", "up-regulation of transport"], "types": ["T043"], "canonical_name": "positive regulation of transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523076", "aliases": ["down regulation of transport", "down-regulation of transport", "downregulation of transport"], "types": ["T043"], "canonical_name": "negative regulation of transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523077", "aliases": ["regulation of DNA metabolism"], "types": ["T045"], "canonical_name": "regulation of DNA metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. [GOC:ai]"}
{"concept_id": "C1523078", "aliases": ["down regulation of DNA metabolic process", "negative regulation of DNA metabolism", "down-regulation of DNA metabolic process", "downregulation of DNA metabolic process"], "types": ["T045"], "canonical_name": "negative regulation of DNA metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. [GOC:ai]"}
{"concept_id": "C1523079", "aliases": ["positive regulation of DNA metabolism", "up-regulation of DNA metabolic process", "upregulation of DNA metabolic process", "up regulation of DNA metabolic process"], "types": ["T045"], "canonical_name": "positive regulation of DNA metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. [GOC:ai]"}
{"concept_id": "C1523080", "aliases": ["down-regulation of lipid biosynthetic process", "negative regulation of lipid synthesis", "downregulation of lipid biosynthetic process", "negative regulation of lipid anabolism", "inhibition of lipid biosynthetic process", "negative regulation of lipogenesis", "negative regulation of lipid biosynthesis", "negative regulation of lipid formation", "down regulation of lipid biosynthetic process"], "types": ["T040"], "canonical_name": "negative regulation of lipid biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. [GOC:ai]"}
{"concept_id": "C1523081", "aliases": ["regulation of small GTPase-mediated signal transduction"], "types": ["T044"], "canonical_name": "regulation of small GTPase mediated signal transduction", "definition": "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:go_curators]"}
{"concept_id": "C1523082", "aliases": ["up-regulation of small GTPase mediated signal transduction", "up regulation of small GTPase mediated signal transduction", "upregulation of small GTPase mediated signal transduction", "positive regulation of small GTPase-mediated signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of small GTPase mediated signal transduction", "definition": "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:ai]"}
{"concept_id": "C1523083", "aliases": ["downregulation of small GTPase mediated signal transduction", "negative regulation of small GTPase-mediated signal transduction", "down-regulation of small GTPase mediated signal transduction", "down regulation of small GTPase mediated signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of small GTPase mediated signal transduction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:ai]"}
{"concept_id": "C1523084", "aliases": [], "types": ["T045"], "canonical_name": "NF-kappaB binding", "definition": "Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. [GOC:ai]"}
{"concept_id": "C1523085", "aliases": [], "types": ["T044"], "canonical_name": "ADP reductase activity", "definition": "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin. [MetaCyc:ADPREDUCT-RXN]"}
{"concept_id": "C1523086", "aliases": [], "types": ["T044"], "canonical_name": "UDP reductase activity", "definition": "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin. [MetaCyc:UDPREDUCT-RXN]"}
{"concept_id": "C1523087", "aliases": [], "types": ["T044"], "canonical_name": "CDP reductase activity", "definition": "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin. [MetaCyc:CDPREDUCT-RXN]"}
{"concept_id": "C1523088", "aliases": [], "types": ["T044"], "canonical_name": "TTP reductase activity", "definition": "Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. [MetaCyc:1.17.4.2-RXN]"}
{"concept_id": "C1523089", "aliases": [], "types": ["T044"], "canonical_name": "CTP reductase activity", "definition": "Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. [MetaCyc:1.17.4.2-RXN]"}
{"concept_id": "C1523090", "aliases": ["dihydropterin metabolism", "dihydropterin metabolic process"], "types": ["T044"], "canonical_name": "dihydrobiopterin metabolic process", "definition": "The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions. [PMID:2557335]"}
{"concept_id": "C1523091", "aliases": ["6,7-dihydropteridine metabolic process", "dihydropteridine metabolism"], "types": ["T044"], "canonical_name": "dihydropteridine metabolic process", "definition": "The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4. [PMID:2557335]"}
{"concept_id": "C1523092", "aliases": ["dihydrothioctamide metabolism", "dihydrolipoamide metabolism", "dihydrothioctamide metabolic process"], "types": ["T044"], "canonical_name": "dihydrolipoamide metabolic process", "definition": "The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor. [ISBN:0721601464]"}
{"concept_id": "C1523093", "aliases": ["galactomannan metabolism"], "types": ["T044"], "canonical_name": "galactomannan metabolic process", "definition": "The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units. [http://www.els.net/els/public/glossary/]"}
{"concept_id": "C1523094", "aliases": ["galactomannan formation", "galactomannan anabolism", "galactomannan biosynthesis", "galactomannan synthesis"], "types": ["T044"], "canonical_name": "galactomannan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units. [GOC:ai]"}
{"concept_id": "C1523095", "aliases": ["4,6-pyruvylated galactose residue metabolism", "PvGal metabolism", "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism", "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process", "PvGal metabolic process"], "types": ["T044"], "canonical_name": "4,6-pyruvylated galactose residue metabolic process", "definition": "The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain. [GOC:ai, PMID:15173185]"}
{"concept_id": "C1523096", "aliases": ["4,6-pyruvylated galactose residue synthesis", "4,6-pyruvylated galactose residue biosynthesis", "4,6-pyruvylated galactose residue anabolism", "PvGal biosynthetic process", "4,6-pyruvylated galactose residue formation", "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis", "PvGal biosynthesis", "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process"], "types": ["T044"], "canonical_name": "4,6-pyruvylated galactose residue biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain. [GOC:ai, PMID:15173185]"}
{"concept_id": "C1523097", "aliases": ["adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity", "cobalamin synthase activity", "cobalamin-5'-phosphate synthase activity", "cobalamin 5'-phosphate synthase activity", "cobalamin (5'-phosphate) synthase activity", "CobS"], "types": ["T044"], "canonical_name": "adenosylcobinamide-GDP ribazoletransferase activity", "definition": "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP. [MetaCyc:COBALAMIN5PSYN-RXN]"}
{"concept_id": "C1523099", "aliases": ["S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity"], "types": ["T044"], "canonical_name": "S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity", "definition": "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA. [PMID:12731872]"}
{"concept_id": "C1523101", "aliases": ["secondary septum"], "types": ["T026"], "canonical_name": "secondary cell septum", "definition": "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum. [GOC:mtg_sensu, PMID:15194814]"}
{"concept_id": "C1523102", "aliases": ["meiotic nuclear envelope degradation", "meiotic nuclear envelope catabolism", "meiotic nuclear envelope breakdown"], "types": ["T043"], "canonical_name": "meiotic nuclear envelope disassembly"}
{"concept_id": "C1523103", "aliases": ["meiosis I nuclear envelope degradation", "meiosis I nuclear envelope catabolism", "meiosis I nuclear envelope breakdown"], "types": ["T043"], "canonical_name": "meiosis I nuclear envelope disassembly"}
{"concept_id": "C1523104", "aliases": ["meiosis II nuclear envelope degradation", "meiosis II nuclear envelope breakdown", "meiosis II nuclear envelope catabolism"], "types": ["T043"], "canonical_name": "meiosis II nuclear envelope disassembly"}
{"concept_id": "C1523105", "aliases": ["nuclear envelope disassembly", "nuclear envelope catabolism", "nuclear membrane disassembly", "nuclear envelope breakdown"], "types": ["T043"], "definition": "The controlled breakdown of the nuclear membranes, for example during cellular division. [GOC:ai]", "canonical_name": "nuclear envelope degradation"}
{"concept_id": "C1523106", "aliases": [], "types": ["T044"], "canonical_name": "unfolded protein binding", "definition": "Binding to an unfolded protein. [GOC:ai]"}
{"concept_id": "C1523107", "aliases": ["multidomain protein assembly", "'de novo' co-translational protein folding", "nascent polypeptide association"], "types": ["T044"], "canonical_name": "'de novo' cotranslational protein folding", "definition": "The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated. [GOC:rb]"}
{"concept_id": "C1523109", "aliases": ["chaperone mediated protein folding requiring cofactor", "chaperone cofactor-dependent 'de novo' protein folding", "chaperone cofactor-dependent protein folding"], "types": ["T044"], "canonical_name": "chaperone co-factor-dependent protein folding"}
{"concept_id": "C1523110", "aliases": ["chaperone cofactor-independent protein folding"], "types": ["T044"], "canonical_name": "chaperone mediated protein folding independent of cofactor", "definition": "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release. [GOC:rb]"}
{"concept_id": "C1523111", "aliases": ["chaperone protein binding"], "types": ["T044"], "canonical_name": "chaperone binding", "definition": "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]"}
{"concept_id": "C1523113", "aliases": [], "types": ["T044"], "canonical_name": "constitutive protein ectodomain proteolysis", "definition": "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands. [PMID:12714508]"}
{"concept_id": "C1523114", "aliases": ["regulation of transcription factor activity"], "types": ["T045"], "canonical_name": "regulation of transcription factor activity"}
{"concept_id": "C1523115", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription factor activity"}
{"concept_id": "C1523116", "aliases": ["NF-kappaB activation", "activation of NF-kappaB", "activation of NF-kappaB transcription factor"], "types": ["T043"], "canonical_name": "positive regulation of NF-kappaB transcription factor activity", "definition": "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]"}
{"concept_id": "C1523119", "aliases": [], "types": ["T044"], "canonical_name": "regulation of helicase activity", "definition": "Any process that modulates the frequency, rate or extent of helicase activity. [GOC:ai]"}
{"concept_id": "C1523120", "aliases": ["up regulation of helicase activity", "up-regulation of helicase activity", "upregulation of helicase activity"], "types": ["T044"], "canonical_name": "positive regulation of helicase activity", "definition": "Any process that activates or increases the activity of a helicase. [GOC:ai]"}
{"concept_id": "C1523121", "aliases": ["down regulation of helicase activity", "down-regulation of helicase activity", "downregulation of helicase activity"], "types": ["T044"], "canonical_name": "negative regulation of helicase activity", "definition": "Any process that stops or reduces the activity of a helicase. [GOC:ai]"}
{"concept_id": "C1523122", "aliases": [], "types": ["T044"], "canonical_name": "regulation of binding", "definition": "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. [GOC:ai]"}
{"concept_id": "C1523123", "aliases": ["up regulation of binding", "upregulation of binding", "up-regulation of binding"], "types": ["T044"], "canonical_name": "positive regulation of binding", "definition": "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. [GOC:ai]"}
{"concept_id": "C1523124", "aliases": ["downregulation of binding", "down-regulation of binding", "down regulation of binding"], "types": ["T044"], "canonical_name": "negative regulation of binding", "definition": "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. [GOC:ai]"}
{"concept_id": "C1523125", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA binding", "definition": "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1523126", "aliases": [], "types": ["T045"], "canonical_name": "DNA ligation during DNA recombination"}
{"concept_id": "C1523127", "aliases": [], "types": ["T045"], "canonical_name": "DNA ligation during DNA repair"}
{"concept_id": "C1523128", "aliases": [], "types": ["T045"], "canonical_name": "DNA ligation during DNA-dependent DNA replication"}
{"concept_id": "C1523129", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA ligation", "definition": "Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. [GOC:ai]"}
{"concept_id": "C1523130", "aliases": ["upregulation of DNA ligation", "up-regulation of DNA ligation", "up regulation of DNA ligation"], "types": ["T045"], "canonical_name": "positive regulation of DNA ligation", "definition": "Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. [GOC:ai]"}
{"concept_id": "C1523131", "aliases": ["down-regulation of DNA ligation", "down regulation of DNA ligation", "downregulation of DNA ligation"], "types": ["T045"], "canonical_name": "negative regulation of DNA ligation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. [GOC:ai]"}
{"concept_id": "C1523132", "aliases": ["carnitine synthetase activity"], "types": ["T044"], "canonical_name": "carnitine-CoA ligase activity", "definition": "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA. [MetaCyc:DCARNCOALIG-RXN]"}
{"concept_id": "C1523133", "aliases": ["crotonobetaine-CoA synthase activity"], "types": ["T044"], "canonical_name": "crotonobetaine-CoA ligase activity", "definition": "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA. [MetaCyc:CROTCOALIG-RXN]"}
{"concept_id": "C1523134", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine", "definition": "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine). [RESID:AA0372]"}
{"concept_id": "C1523135", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine adenylylation", "definition": "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine). [RESID:AA0371]"}
{"concept_id": "C1523136", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine", "definition": "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine). [RESID:AA0371]"}
{"concept_id": "C1523138", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine uridylylation", "definition": "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine). [RESID:AA0372]"}
{"concept_id": "C1523140", "aliases": ["hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)", "hydrogenobyrinic acid a,c-diamide cobaltochelatase activity", "CobN-CobST", "CobNST"], "types": ["T044"], "canonical_name": "cobaltochelatase activity", "definition": "Catalysis of the reaction: ATP + Co(2+) + H(2)O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H(+) + phosphate. [EC:6.6.1.2, RHEA:15341]"}
{"concept_id": "C1523141", "aliases": [], "types": ["T044"], "canonical_name": "ATPase binding", "definition": "Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]"}
{"concept_id": "C1523142", "aliases": ["cariogenanase activity", "cariogenase activity", "1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity", "endo-1,3-alpha-D-glucanase activity", "endo-(1->3)-alpha-glucanase activity", "endo-1,3-alpha-glucanase activity", "mutanase activity"], "types": ["T044"], "canonical_name": "glucan endo-1,3-alpha-glucosidase activity", "definition": "Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran. [EC:3.2.1.59]"}
{"concept_id": "C1523144", "aliases": [], "types": ["T044"], "canonical_name": "hepoxilin A3 synthase activity", "definition": "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3. [PMID:15123652]"}
{"concept_id": "C1523145", "aliases": ["hepoxilin metabolism"], "types": ["T044"], "canonical_name": "hepoxilin metabolic process", "definition": "The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology. [PMID:15123652]"}
{"concept_id": "C1523146", "aliases": ["hepoxilin anabolism", "hepoxilin biosynthesis", "hepoxilin formation", "hepoxilin synthesis"], "types": ["T044"], "canonical_name": "hepoxilin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology. [GOC:ai]"}
{"concept_id": "C1523147", "aliases": ["transcriptional preinitiation complex formation", "transcription PIC biosynthesis"], "types": ["T045"], "canonical_name": "transcription PIC formation"}
{"concept_id": "C1523148", "aliases": [], "types": ["T042"], "canonical_name": "synaptic growth at neuromuscular junction"}
{"concept_id": "C1523149", "aliases": [], "types": ["T044"], "canonical_name": "regulation of actin nucleation", "definition": "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. [GOC:ai]"}
{"concept_id": "C1523150", "aliases": ["down-regulation of actin nucleation", "down regulation of actin nucleation", "downregulation of actin nucleation"], "types": ["T044"], "canonical_name": "negative regulation of actin nucleation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. [GOC:ai]"}
{"concept_id": "C1523151", "aliases": ["up regulation of actin nucleation", "up-regulation of actin nucleation", "upregulation of actin nucleation"], "types": ["T044"], "canonical_name": "positive regulation of actin nucleation", "definition": "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. [GOC:ai]"}
{"concept_id": "C1523152", "aliases": ["regulation of cellular component organisation", "regulation of cell organization", "regulation of cell organisation", "regulation of cellular component organization and biogenesis"], "types": ["T043"], "canonical_name": "regulation of cellular component organization", "definition": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. [GOC:ai]"}
{"concept_id": "C1523153", "aliases": ["negative regulation of cellular component organization and biogenesis", "inhibition of cell organization", "negative regulation of cell organisation", "down-regulation of cell organization", "down regulation of cell organization", "downregulation of cell organization"], "types": ["T043"], "canonical_name": "negative regulation of cellular component organization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. [GOC:ai]"}
{"concept_id": "C1523154", "aliases": ["positive regulation of cell organisation", "up regulation of cell organization", "activation of cell organization", "up-regulation of cell organization", "positive regulation of cellular component organization and biogenesis", "upregulation of cell organization", "stimulation of cell organization"], "types": ["T043"], "canonical_name": "positive regulation of cellular component organization", "definition": "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. [GOC:ai]"}
{"concept_id": "C1523156", "aliases": ["natural killer T cell activation", "NK T-lymphocyte activation", "NK T lymphocyte activation", "NKT cell activation", "natural T cell activation", "NK T-cell activation", "NT cell activation"], "types": ["T043"], "canonical_name": "NK T cell activation", "definition": "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523157", "aliases": ["regulation of NKT cell activation", "regulation of NK T-lymphocyte activation", "regulation of NK T lymphocyte activation", "regulation of NT cell activation", "regulation of NK T-cell activation", "regulation of natural killer T cell activation", "regulation of natural T cell activation"], "types": ["T043"], "canonical_name": "regulation of NK T cell activation", "definition": "Any process that modulates the frequency, rate or extent of natural killer T cell activation. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523158", "aliases": ["negative regulation of NK T lymphocyte activation", "negative regulation of NK T-lymphocyte activation", "negative regulation of NT cell activation", "down regulation of NK T cell activation", "down-regulation of NK T cell activation", "negative regulation of NK T-cell activation", "negative regulation of natural killer T cell activation", "negative regulation of natural T cell activation", "negative regulation of NKT cell activation", "downregulation of NK T cell activation"], "types": ["T043"], "canonical_name": "negative regulation of NK T cell activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523159", "aliases": ["positive regulation of natural T cell activation", "positive regulation of NK T lymphocyte activation", "positive regulation of natural killer T cell activation", "positive regulation of NK T-cell activation", "positive regulation of NKT cell activation", "up regulation of NK T cell activation", "upregulation of NK T cell activation", "up-regulation of NK T cell activation", "positive regulation of NK T-lymphocyte activation", "positive regulation of NT cell activation"], "types": ["T043"], "canonical_name": "positive regulation of NK T cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523160", "aliases": ["regulation of NT cell differentiation", "regulation of NK T lymphocyte differentiation", "regulation of NK T-cell differentiation", "regulation of natural killer T cell differentiation", "regulation of NKT cell differentiation", "regulation of NK T-lymphocyte differentiation", "regulation of natural T cell differentiation"], "types": ["T043"], "canonical_name": "regulation of NK T cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523161", "aliases": ["negative regulation of NK T-cell differentiation", "negative regulation of natural T cell differentiation", "negative regulation of NK T-lymphocyte differentiation", "downregulation of NK T cell differentiation", "negative regulation of NK T lymphocyte differentiation", "negative regulation of NT cell differentiation", "down regulation of NK T cell differentiation", "negative regulation of natural killer T cell differentiation", "negative regulation of NKT cell differentiation", "down-regulation of NK T cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of NK T cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523162", "aliases": ["positive regulation of natural T cell differentiation", "positive regulation of NT cell differentiation", "up-regulation of NK T cell differentiation", "positive regulation of NKT cell differentiation", "positive regulation of NK T lymphocyte differentiation", "positive regulation of NK T-lymphocyte differentiation", "upregulation of NK T cell differentiation", "positive regulation of NK T-cell differentiation", "positive regulation of natural killer T cell differentiation", "up regulation of NK T cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of NK T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523163", "aliases": ["metal ion:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "metal ion:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). [GOC:mlg]"}
{"concept_id": "C1523164", "aliases": ["regulation of NK T-lymphocyte proliferation", "regulation of NK T lymphocyte proliferation", "regulation of natural killer T cell proliferation", "regulation of NK T-cell proliferation", "regulation of natural T cell proliferation", "regulation of NKT cell proliferation", "regulation of NT cell proliferation"], "types": ["T043"], "canonical_name": "regulation of NK T cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523165", "aliases": ["negative regulation of NT cell proliferation", "downregulation of NK T cell proliferation", "negative regulation of NK T-lymphocyte proliferation", "negative regulation of NK T-cell proliferation", "down regulation of NK T cell proliferation", "negative regulation of natural killer T cell proliferation", "down-regulation of NK T cell proliferation", "negative regulation of NK T lymphocyte proliferation", "negative regulation of natural T cell proliferation", "negative regulation of NKT cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of NK T cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523166", "aliases": ["positive regulation of NK T-lymphocyte proliferation", "positive regulation of natural killer T cell proliferation", "positive regulation of NT cell proliferation", "upregulation of NK T cell proliferation", "up-regulation of NK T cell proliferation", "positive regulation of NK T-cell proliferation", "positive regulation of natural T cell proliferation", "positive regulation of NK T lymphocyte proliferation", "positive regulation of NKT cell proliferation", "up regulation of NK T cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of NK T cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation. [ISBN:0781735149, PMID:12154375, PMID:9133426]"}
{"concept_id": "C1523167", "aliases": ["propylene glycol metabolism", "propanediol metabolism", "1,2-dihydroxypropane metabolic process", "1,2-dihydroxypropane metabolism", "propylene glycol metabolic process"], "types": ["T044"], "canonical_name": "propanediol metabolic process", "definition": "The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items. [PMID:15995211]"}
{"concept_id": "C1523168", "aliases": ["propanediol degradation", "propanediol catabolism", "propanediol breakdown", "propylene glycol catabolism", "1,2-dihydroxypropane catabolism", "propylene glycol catabolic process", "1,2-dihydroxypropane catabolic process"], "types": ["T044"], "canonical_name": "propanediol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH. [GOC:ai]"}
{"concept_id": "C1523169", "aliases": ["nonstriated muscle cell differentiation"], "types": ["T043"], "canonical_name": "smooth muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. [CL:0000192, GOC:ai]"}
{"concept_id": "C1523170", "aliases": [], "types": ["T043"], "canonical_name": "voluntary muscle cell differentiation"}
{"concept_id": "C1523171", "aliases": [], "types": ["T043"], "canonical_name": "regulation of muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of muscle cell differentiation. [CL:0000187, GOC:ai]"}
{"concept_id": "C1523172", "aliases": ["downregulation of muscle cell differentiation", "down regulation of muscle cell differentiation", "down-regulation of muscle cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of muscle cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. [CL:0000187, GOC:ai]"}
{"concept_id": "C1523173", "aliases": ["up-regulation of muscle cell differentiation", "up regulation of muscle cell differentiation", "upregulation of muscle cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. [CL:0000187, GOC:ai]"}
{"concept_id": "C1523174", "aliases": [], "types": ["T043"], "canonical_name": "regulation of smooth muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. [CL:0000192, GOC:ai]"}
{"concept_id": "C1523175", "aliases": ["down-regulation of smooth muscle cell differentiation", "downregulation of smooth muscle cell differentiation", "down regulation of smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of smooth muscle cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. [CL:0000192, GOC:ai]"}
{"concept_id": "C1523176", "aliases": ["up-regulation of smooth muscle cell differentiation", "up regulation of smooth muscle cell differentiation", "upregulation of smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of smooth muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. [CL:0000192, GOC:ai]"}
{"concept_id": "C1523177", "aliases": [], "types": ["T043"], "canonical_name": "regulation of striated muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. [CL:0000737, GOC:ai]"}
{"concept_id": "C1523178", "aliases": ["down-regulation of striated muscle cell differentiation", "down regulation of striated muscle cell differentiation", "downregulation of striated muscle cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of striated muscle cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. [CL:0000737, GOC:ai]"}
{"concept_id": "C1523179", "aliases": ["upregulation of striated muscle cell differentiation", "up regulation of striated muscle cell differentiation", "up-regulation of striated muscle cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of striated muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. [CL:0000737, GOC:ai]"}
{"concept_id": "C1523180", "aliases": ["glucose 6-phosphate utilization", "glucose 6-phosphate metabolism"], "types": ["T044"], "canonical_name": "glucose 6-phosphate metabolic process", "definition": "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. [GOC:ai]"}
{"concept_id": "C1523181", "aliases": ["arabitol catabolism", "arabitol breakdown", "arabitol utilization", "arabitol degradation"], "types": ["T044"], "canonical_name": "arabitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1523182", "aliases": ["L-arabitol breakdown", "L-arabitol degradation", "L-arabitol catabolism"], "types": ["T044"], "canonical_name": "L-arabitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1523183", "aliases": ["D-arabitol catabolism", "D-arabitol degradation", "D-arabitol breakdown"], "types": ["T044"], "canonical_name": "D-arabitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. [ISBN:0198506732]"}
{"concept_id": "C1523184", "aliases": ["L-xylitol breakdown", "L-xylitol degradation", "L-xylitol catabolism"], "types": ["T044"], "canonical_name": "L-xylitol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. [GOC:ai]"}
{"concept_id": "C1523185", "aliases": ["arabitol metabolism"], "types": ["T044"], "canonical_name": "arabitol metabolic process", "definition": "The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1523186", "aliases": ["L-arabitol metabolism"], "types": ["T044"], "canonical_name": "L-arabitol metabolic process", "definition": "The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. [ISBN:0198506732]"}
{"concept_id": "C1523187", "aliases": ["D-arabitol metabolism"], "types": ["T044"], "canonical_name": "D-arabitol metabolic process", "definition": "The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. [ISBN:0198506732]"}
{"concept_id": "C1523188", "aliases": ["L-xylitol metabolism"], "types": ["T044"], "canonical_name": "L-xylitol metabolic process", "definition": "The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets. [GOC:ai]"}
{"concept_id": "C1523189", "aliases": ["2,5-dihydroxypyridine metabolism", "pyridine-2,5-diol metabolic process"], "types": ["T044"], "canonical_name": "2,5-dihydroxypyridine metabolic process", "definition": "The chemical reactions and pathways involving 2,5-dihydroxypyridine. [GOC:ai]"}
{"concept_id": "C1523190", "aliases": ["pyridine-2,5-diol catabolic process", "2,5-dihydroxypyridine breakdown", "2,5-dihydroxypyridine catabolism", "2,5-dihydroxypyridine degradation"], "types": ["T044"], "canonical_name": "2,5-dihydroxypyridine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine. [GOC:ai]"}
{"concept_id": "C1523191", "aliases": ["D-xylulose-5-phosphate metabolic process", "D-xylulose 5-phosphate metabolism", "D-xylulose 5-phosphate metabolic process", "D-xylulose-5-phosphate metabolism", "xylulose-5-phosphate metabolic process", "xylulose-5-phosphate metabolism", "xylulose 5-phosphate metabolism"], "types": ["T044"], "canonical_name": "xylulose 5-phosphate metabolic process", "definition": "The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway. [ISBN:0721662544]"}
{"concept_id": "C1523192", "aliases": ["regulation of nitrogen metabolism", "regulation of nitrogen metabolic process"], "types": ["T044"], "canonical_name": "regulation of nitrogen compound metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. [GOC:ai, GOC:tb]"}
{"concept_id": "C1523193", "aliases": ["down-regulation of nitrogen metabolic process", "negative regulation of nitrogen metabolism", "downregulation of nitrogen metabolic process", "negative regulation of nitrogen metabolic process", "down regulation of nitrogen metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of nitrogen compound metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. [GOC:ai, GOC:tb]"}
{"concept_id": "C1523194", "aliases": ["up regulation of nitrogen metabolic process", "upregulation of nitrogen metabolic process", "positive regulation of nitrogen metabolism", "up-regulation of nitrogen metabolic process", "positive regulation of nitrogen metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of nitrogen compound metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. [GOC:ai, GOC:tb]"}
{"concept_id": "C1523195", "aliases": ["regulation of phosphorus metabolism"], "types": ["T044"], "canonical_name": "regulation of phosphorus metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. [GOC:ai]"}
{"concept_id": "C1523196", "aliases": ["downregulation of sulfur metabolic process", "down-regulation of sulfur metabolic process", "negative regulation of sulphur metabolic process", "negative regulation of sulfur metabolism", "down regulation of sulfur metabolic process", "negative regulation of sulphur metabolism"], "types": ["T044"], "canonical_name": "negative regulation of sulfur metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. [GOC:ai]"}
{"concept_id": "C1523197", "aliases": ["upregulation of sulfur metabolic process", "positive regulation of sulfur metabolism", "positive regulation of sulphur metabolism", "up regulation of sulfur metabolic process", "up-regulation of sulfur metabolic process", "positive regulation of sulphur metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of sulfur metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. [GOC:ai]"}
{"concept_id": "C1523198", "aliases": [], "types": ["T043"], "canonical_name": "meiotic sister chromatid cohesion", "definition": "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis. [GOC:ai]"}
{"concept_id": "C1523200", "aliases": [], "types": ["T043"], "canonical_name": "vitamin transport", "definition": "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]"}
{"concept_id": "C1523209", "aliases": ["prosthetic group metabolism"], "types": ["T044"], "canonical_name": "prosthetic group metabolic process", "definition": "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. [GOC:ai]"}
{"concept_id": "C1523210", "aliases": ["prosthetic group catabolism", "prosthetic group breakdown", "prosthetic group degradation"], "types": ["T044"], "canonical_name": "prosthetic group catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. [GOC:ai]"}
{"concept_id": "C1523211", "aliases": ["prosthetic group biosynthesis", "prosthetic group synthesis", "prosthetic group anabolism", "prosthetic group formation"], "types": ["T044"], "canonical_name": "prosthetic group biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. [GOC:ai]"}
{"concept_id": "C1523212", "aliases": [], "types": ["T044"], "canonical_name": "prosthetic group binding", "definition": "Binding to a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. [GOC:ai, GOC:vw]"}
{"concept_id": "C1523222", "aliases": ["phytochromobilin metabolism"], "types": ["T044"], "canonical_name": "phytochromobilin metabolic process", "definition": "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity. [PMID:11500553]"}
{"concept_id": "C1523223", "aliases": ["peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde", "peptidyl-aspartic acid reduction to form L-beta-formylalanine"], "types": ["T044"], "canonical_name": "peptidyl-aspartic acid reduction to form L-aspartyl aldehyde", "definition": "The reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein. [PMID:15237995, RESID:AA0373]"}
{"concept_id": "C1523224", "aliases": ["localization of protein in mitochondrial membrane", "protein insertion into mitochondrion membrane", "protein-mitochondrial membrane insertion", "positioning of protein in mitochondrial membrane", "protein-mitochondrion membrane insertion", "integral mitochondrial membrane protein positioning", "integral mitochondrial membrane protein localization"], "types": ["T043"], "canonical_name": "protein insertion into mitochondrial membrane", "definition": "The process that results in the incorporation of a protein into a mitochondrial membrane. [GOC:ai]"}
{"concept_id": "C1523225", "aliases": ["integral membrane protein localization", "membrane protein positioning", "integral membrane protein positioning", "membrane protein localization", "protein-membrane insertion"], "types": ["T043"], "canonical_name": "protein insertion into membrane", "definition": "The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. [GOC:ai]"}
{"concept_id": "C1523226", "aliases": ["silicate metabolism"], "types": ["T044"], "canonical_name": "silicate metabolic process", "definition": "The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. [GOC:ai]"}
{"concept_id": "C1523228", "aliases": ["retention of calcium ion (Ca2+)", "calcium ion (Ca2+) storage", "storage of calcium ion (Ca2+)", "sequestering of calcium ion (Ca2+)", "calcium ion (Ca2+) sequestration", "calcium ion (Ca2+) retention", "calcium ion (Ca2+) sequestering", "sequestration of calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "sequestering of calcium ion", "definition": "The process of binding or confining calcium ions such that they are separated from other components of a biological system. [GOC:ai]"}
{"concept_id": "C1523229", "aliases": [], "types": ["T043"], "canonical_name": "uniform cell growth"}
{"concept_id": "C1523230", "aliases": ["non-isotropic cell growth"], "types": ["T043"], "canonical_name": "anisotropic cell growth", "definition": "The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell. [GOC:ai]"}
{"concept_id": "C1523231", "aliases": ["V ion binding"], "types": ["T044"], "canonical_name": "vanadium ion binding", "definition": "Binding to a vanadium ion (V). [GOC:ai]"}
{"concept_id": "C1523232", "aliases": [], "types": ["T044"], "definition": "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]", "canonical_name": "dioxygenase activity"}
{"concept_id": "C1523233", "aliases": ["RNA VIGS", "RNA virus induced gene silencing", "RNA virus-induced PTGS", "RNA virus-induced gene silencing"], "types": ["T045"], "canonical_name": "RNAi-mediated antiviral immunity against RNA virus", "definition": "An RNAi-mediated post-transcriptional gene silencing pathway induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or inhibition of translation. In plants, DCL4 is the primary Dicer to detect RNA viruses. [PMID:15165191, PMID:17693253]"}
{"concept_id": "C1523234", "aliases": ["DNA virus-induced gene silencing", "DNA virus induced gene silencing", "DNA virus-induced PTGS", "DNA VIGS"], "types": ["T045"], "canonical_name": "RNAi-mediated antiviral immunity against DNA virus", "definition": "An RNAi-mediated post-transcriptional gene silencing pathway induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or inhibition of translation. In plants, DCL3 is the primary Dicer to detect DNA viruses. [PMID:15165191, PMID:17693253, PMID:23151511]"}
{"concept_id": "C1523235", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)", "definition": "The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide). [PDB:1Q16, PMID:12910261, RESID:AA0375]"}
{"concept_id": "C1523236", "aliases": [], "types": ["T044"], "canonical_name": "tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)", "definition": "The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide). [PDB:1HOH, PMID:12220497, RESID:AA0376]"}
{"concept_id": "C1523237", "aliases": ["phosphorylated protein binding"], "types": ["T044"], "canonical_name": "phosphoprotein binding", "definition": "Binding to a phosphorylated protein. [GOC:ai]"}
{"concept_id": "C1523238", "aliases": ["cytoplasmic sequestration of protein", "cytoplasmic storage of protein", "sequestering of protein in cytoplasm", "retention of protein in cytoplasm", "maintenance of protein location in cytoplasm", "storage of protein in cytoplasm", "sequestration of protein in cytoplasm", "cytoplasmic retention of protein"], "types": ["T043"], "canonical_name": "cytoplasmic sequestering of protein", "definition": "The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. [GOC:ai]"}
{"concept_id": "C1523239", "aliases": ["tungsten incorporation into metallo-sulphur cluster"], "types": ["T044"], "canonical_name": "tungsten incorporation into metallo-sulfur cluster", "definition": "The incorporation of tungsten into a metallo-sulfur cluster. [GOC:ai]"}
{"concept_id": "C1523240", "aliases": ["upregulation of protein transport", "up regulation of protein transport", "up-regulation of protein transport"], "types": ["T043"], "canonical_name": "positive regulation of protein transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523241", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523242", "aliases": ["down regulation of protein transport", "down-regulation of protein transport", "downregulation of protein transport"], "types": ["T043"], "canonical_name": "negative regulation of protein transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1523243", "aliases": ["spindle breakdown during mitosis", "mitotic spindle catabolism", "mitotic spindle degradation", "mitotic spindle breakdown", "spindle degradation during mitosis", "spindle disassembly during mitosis"], "types": ["T043"], "canonical_name": "mitotic spindle disassembly", "definition": "The controlled breakdown of the spindle during a mitotic cell cycle. [GOC:ai]"}
{"concept_id": "C1523244", "aliases": ["meiotic spindle degradation", "spindle breakdown during meiosis", "meiotic spindle breakdown", "spindle disassembly during meiosis", "meiotic spindle catabolism", "spindle degradation during meiosis"], "types": ["T043"], "canonical_name": "meiotic spindle disassembly", "definition": "The controlled breakdown of the spindle during a meiotic cell cycle. [GOC:ai]"}
{"concept_id": "C1523245", "aliases": ["spindle catabolism", "spindle breakdown", "spindle degradation"], "types": ["T043"], "canonical_name": "spindle disassembly", "definition": "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. [GOC:ai]"}
{"concept_id": "C1523246", "aliases": [], "types": ["T043"], "canonical_name": "spindle elongation", "definition": "The cell cycle process in which the distance is lengthened between poles of the spindle. [GOC:ai]"}
{"concept_id": "C1523247", "aliases": ["spindle elongation during meiosis"], "types": ["T043"], "canonical_name": "meiotic spindle elongation", "definition": "The lengthening of the distance between poles of the spindle during a meiotic cell cycle. [GOC:ai]"}
{"concept_id": "C1523248", "aliases": ["spindle equator", "central spindle"], "types": ["T026"], "canonical_name": "spindle midzone", "definition": "The area in the center of the spindle where the spindle microtubules from opposite poles overlap. [GOC:ai, PMID:15296749]"}
{"concept_id": "C1523249", "aliases": ["establishment of localisation"], "types": ["T043"], "canonical_name": "establishment of localization", "definition": "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos]"}
{"concept_id": "C1523250", "aliases": ["RNA recruitment", "RNA positioning", "establishment of RNA localisation"], "types": ["T043"], "canonical_name": "establishment of RNA localization", "definition": "The directed movement of RNA to a specific location. [GOC:ai]"}
{"concept_id": "C1523251", "aliases": ["RNA retention", "maintenance of RNA localization"], "types": ["T045"], "canonical_name": "maintenance of RNA location", "definition": "Any process in which RNA is maintained in a location and prevented from moving elsewhere. [GOC:ai]"}
{"concept_id": "C1523252", "aliases": ["metal ion retention", "retention of metal ion", "storage of metal ion", "metal ion storage", "sequestration of metal ion", "metal ion sequestering", "metal ion sequestration"], "types": ["T038"], "canonical_name": "sequestering of metal ion", "definition": "The process of binding or confining metal ions such that they are separated from other components of a biological system. [GOC:ai]"}
{"concept_id": "C1523259", "aliases": ["down regulation of cellular defense response", "negative regulation of cellular defence response", "down-regulation of cellular defense response", "downregulation of cellular defense response"], "types": ["T043"], "canonical_name": "negative regulation of cellular defense response", "definition": "Any process that stops, prevents, or reduces the rate of the cellular defense response. [GOC:ai]"}
{"concept_id": "C1523260", "aliases": ["regulation of protein metabolism"], "types": ["T044"], "canonical_name": "regulation of protein metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. [GOC:ai]"}
{"concept_id": "C1523261", "aliases": ["up-regulation of cellular protein metabolic process", "up regulation of cellular protein metabolic process", "up regulation of protein metabolic process", "upregulation of protein metabolic process", "positive regulation of protein metabolism", "upregulation of cellular protein metabolic process", "up-regulation of protein metabolic process", "positive regulation of cellular protein metabolic process", "positive regulation of cellular protein metabolism"], "types": ["T044"], "canonical_name": "positive regulation of protein metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. [GOC:ai]"}
{"concept_id": "C1523262", "aliases": ["down-regulation of protein metabolic process", "negative regulation of cellular protein metabolism", "negative regulation of protein metabolism", "negative regulation of cellular protein metabolic process", "down regulation of protein metabolic process", "downregulation of protein metabolic process", "downregulation of cellular protein metabolic process", "down-regulation of cellular protein metabolic process", "down regulation of cellular protein metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of protein metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. [GOC:ai]"}
{"concept_id": "C1523263", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lymphocyte activation", "definition": "Any process that modulates the frequency, rate or extent of lymphocyte activation. [GOC:ai]"}
{"concept_id": "C1523265", "aliases": ["upregulation of lymphocyte activation", "up-regulation of lymphocyte activation", "up regulation of lymphocyte activation"], "types": ["T043"], "canonical_name": "positive regulation of lymphocyte activation", "definition": "Any process that activates or increases the frequency, rate or extent of lymphocyte activation. [GOC:ai]"}
{"concept_id": "C1523266", "aliases": ["regulation of RNA metabolism"], "types": ["T045"], "canonical_name": "regulation of RNA metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. [GOC:ai]"}
{"concept_id": "C1523267", "aliases": ["downregulation of RNA metabolic process", "negative regulation of RNA metabolism", "down-regulation of RNA metabolic process", "down regulation of RNA metabolic process"], "types": ["T045"], "canonical_name": "negative regulation of RNA metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. [GOC:ai]"}
{"concept_id": "C1523268", "aliases": ["up regulation of RNA metabolic process", "positive regulation of RNA metabolism", "up-regulation of RNA metabolic process", "upregulation of RNA metabolic process"], "types": ["T045"], "canonical_name": "positive regulation of RNA metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. [GOC:ai]"}
{"concept_id": "C1523269", "aliases": ["spindle midzone biogenesis", "spindle midzone formation", "spindle midzone biosynthesis"], "types": ["T043"], "canonical_name": "spindle midzone assembly", "definition": "The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. [GOC:ai, PMID:15296749]"}
{"concept_id": "C1523270", "aliases": ["mitotic spindle midzone biosynthesis", "spindle midzone biogenesis involved in mitosis", "spindle midzone formation involved in mitosis", "mitotic spindle midzone formation", "mitotic spindle midzone biogenesis", "spindle midzone assembly involved in mitosis"], "types": ["T043"], "canonical_name": "mitotic spindle midzone assembly", "definition": "The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone. [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120]"}
{"concept_id": "C1523271", "aliases": ["meiotic spindle midzone biosynthesis", "meiotic spindle midzone formation", "spindle midzone formation involved in meiosis", "spindle midzone assembly involved in meiosis", "spindle midzone biosynthesis involved in meiosis", "meiotic spindle midzone biogenesis", "spindle midzone biogenesis involved in meiosis"], "types": ["T043"], "canonical_name": "meiotic spindle midzone assembly", "definition": "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis. [GOC:ai, GOC:expert_rg, GOC:tb]"}
{"concept_id": "C1523272", "aliases": ["protein polymer biosynthesis", "protein polymer biosynthetic process", "protein polymer formation"], "types": ["T044"], "canonical_name": "protein polymerization", "definition": "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. [GOC:ai]"}
{"concept_id": "C1523273", "aliases": ["protein oligomer assembly", "protein oligomerization", "protein oligomer formation"], "types": ["T044"], "canonical_name": "protein complex oligomerization", "definition": "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai, PMID:18293929]"}
{"concept_id": "C1523274", "aliases": ["protein homooligomer formation", "protein homooligomer biosynthesis", "protein homooligomer biosynthetic process", "protein homooligomer assembly"], "types": ["T044"], "canonical_name": "protein homooligomerization", "definition": "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai]"}
{"concept_id": "C1523275", "aliases": ["protein polymer catabolism", "protein polymer breakdown", "protein polymer degradation", "protein polymer catabolic process"], "types": ["T044"], "canonical_name": "protein depolymerization", "definition": "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. [GOC:ai]"}
{"concept_id": "C1523276", "aliases": ["protein tetramer formation", "protein tetramer assembly", "protein tetramer biosynthesis", "protein tetramer biosynthetic process"], "types": ["T044"], "canonical_name": "protein tetramerization", "definition": "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. [GOC:ecd]"}
{"concept_id": "C1523277", "aliases": ["microcin E492 formation by siderophore ester modification of peptidyl-serine", "microcin E492 synthesis by siderophore ester modification of peptidyl-serine", "microcin E492 anabolism by siderophore ester modification of peptidyl-serine"], "types": ["T044"], "canonical_name": "microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine", "definition": "The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain. [RESID:AA0374]"}
{"concept_id": "C1523278", "aliases": ["monooleoylglycerol transacylase activity", "acyl-CoA-independent mono-olein transacylation", "monooleoylglycerol O-acyltransferase activity", "MOG transacylation", "mono-oleoylglycerol transacylase activity", "monoolein transacylation", "mono-oleoylglycerol O-acyltransferase activity"], "types": ["T044"], "canonical_name": "mono-olein transacylation activity", "definition": "Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol. [GOC:ai, PMID:15364929]"}
{"concept_id": "C1523279", "aliases": ["dioleoylglycerol transacylase activity", "DOG transacylation", "acyl-CoA-independent diolein transacylation", "dioleoylglycerol O-acyltransferase activity"], "types": ["T044"], "canonical_name": "diolein transacylation activity", "definition": "Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein. [GOC:ai, PMID:15364929]"}
{"concept_id": "C1523280", "aliases": ["sirohydrochlorin ferrochelatase activity", "sirohydrochlorin ferro-lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. [RHEA:24360]", "canonical_name": "siroheme ferro-lyase (sirohydrochlorin-forming)"}
{"concept_id": "C1523282", "aliases": [], "types": ["T044"], "canonical_name": "alpha-keto amide reductase activity", "definition": "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic. [GOC:ai, PMID:15564669]"}
{"concept_id": "C1523283", "aliases": [], "types": ["T044"], "canonical_name": "alpha-keto ester reductase activity", "definition": "Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic. [GOC:ai, PMID:15564669]"}
{"concept_id": "C1523287", "aliases": ["beta-glucan metabolism"], "types": ["T044"], "canonical_name": "beta-glucan metabolic process", "definition": "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds. [GOC:ai]"}
{"concept_id": "C1523288", "aliases": ["beta-glucan synthesis", "beta-glucan anabolism", "beta-glucan biosynthesis", "beta-glucan formation"], "types": ["T044"], "canonical_name": "beta-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-glucans. [GOC:ai]"}
{"concept_id": "C1523289", "aliases": ["beta-glucan catabolism", "beta-glucan degradation", "beta-glucan breakdown"], "types": ["T044"], "canonical_name": "beta-glucan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of beta-glucans. [GOC:ai]"}
{"concept_id": "C1523292", "aliases": ["GPI-N-acetylglucosaminyltransferase complex", "GPI-GlcNAc transferase complex", "glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex location", "GPI-N-acetylglucosaminyltransferase complex location", "GPI-GnT complex", "GPI-GlcNAc transferase complex location", "GPI-GnT complex location"], "types": ["T026"], "canonical_name": "glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex", "definition": "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast. [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411]"}
{"concept_id": "C1523293", "aliases": ["insect-type retina morphogenesis"], "types": ["T042"], "canonical_name": "compound eye morphogenesis", "definition": "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. [GOC:dph, GOC:mtg_sensu]"}
{"concept_id": "C1523294", "aliases": ["optic lobe placode development", "optic lobe and Bolwig's organ precursor development"], "types": ["T042"], "canonical_name": "insect visual primordium development", "definition": "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:8402833]"}
{"concept_id": "C1523297", "aliases": [], "types": ["T043"], "canonical_name": "compound eye photoreceptor fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. [GOC:mtg_sensu]"}
{"concept_id": "C1523298", "aliases": ["epithelial-mesenchymal transition", "EMT", "mesenchymal cell differentiation from epithelial cell"], "types": ["T043"], "definition": "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:dph, PMID:14701881]", "canonical_name": "epithelial to mesenchymal transition"}
{"concept_id": "C1523299", "aliases": [], "types": ["T042"], "canonical_name": "embryonic epithelial tube formation", "definition": "The morphogenesis of an embryonic epithelium into a tube-shaped structure. [GOC:dph, ISBN:0824072820]"}
{"concept_id": "C1523300", "aliases": [], "types": ["T042"], "canonical_name": "neural plate morphogenesis", "definition": "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. [GOC:dph, ISBN:0878932437]"}
{"concept_id": "C1523302", "aliases": [], "types": ["T042"], "canonical_name": "neural fold formation", "definition": "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. [GOC:dph, ISBN:0878932437]"}
{"concept_id": "C1523303", "aliases": [], "types": ["T042"], "canonical_name": "neural tube closure", "definition": "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. [GOC:dph, ISBN:0878932437]"}
{"concept_id": "C1523305", "aliases": ["phagolysosome formation"], "types": ["T043"], "canonical_name": "phagolysosome assembly", "definition": "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523306", "aliases": [], "types": ["T044"], "canonical_name": "opsonin binding", "definition": "Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523307", "aliases": [], "types": ["T044"], "canonical_name": "opsonin receptor activity", "definition": "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1523308", "aliases": [], "types": ["T044"], "canonical_name": "complement binding", "definition": "Binding to a component or product of the complement cascade. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523309", "aliases": [], "types": ["T044"], "canonical_name": "complement component C1q complex binding", "definition": "Binding to a C1q complex, a component of the classical complement cascade. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523310", "aliases": [], "types": ["T044"], "canonical_name": "complement component C3a binding", "definition": "Binding to a C3a product of the complement cascade. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523311", "aliases": [], "types": ["T044"], "canonical_name": "complement component C3b binding", "definition": "Binding to a C3b product of the complement cascade. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523312", "aliases": [], "types": ["T044"], "canonical_name": "complement component iC3b binding", "definition": "Binding to a iC3b product of the complement cascade. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523313", "aliases": [], "types": ["T044"], "canonical_name": "complement component C3dg binding", "definition": "Binding to a C3dg product of the complement cascade. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523314", "aliases": [], "types": ["T044"], "canonical_name": "complement component C3d binding", "definition": "Binding to a C3d product of the complement cascade. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523315", "aliases": [], "types": ["T044"], "canonical_name": "complement component C4b binding", "definition": "Binding to a C4b product of the classical complement cascade. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523316", "aliases": [], "types": ["T044"], "canonical_name": "complement component C5a binding", "definition": "Binding to a C5a product of the complement cascade. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523317", "aliases": [], "types": ["T044"], "canonical_name": "complement component C1q receptor activity", "definition": "Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1523318", "aliases": [], "types": ["T044"], "canonical_name": "complement component iC3b receptor activity", "definition": "Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1523319", "aliases": [], "types": ["T044"], "canonical_name": "complement component C3dg receptor activity", "definition": "Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1523320", "aliases": [], "types": ["T044"], "canonical_name": "complement component C3d receptor activity", "definition": "Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1523321", "aliases": [], "types": ["T044"], "canonical_name": "complement component C4b receptor activity", "definition": "Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1523322", "aliases": [], "types": ["T044"], "canonical_name": "collectin binding", "definition": "Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523323", "aliases": [], "types": ["T044"], "canonical_name": "collectin receptor activity", "definition": "Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1523324", "aliases": [], "types": ["T044"], "canonical_name": "pentraxin binding", "definition": "Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523325", "aliases": ["NK T-cell differentiation", "NK T-lymphocyte differentiation", "NK T lymphocyte differentiation", "natural T cell differentiation", "NKT cell differentiation", "NT cell differentiation", "natural killer T cell differentiation"], "types": ["T043"], "canonical_name": "NK T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a NK T cell. [GOC:add, ISBN:0781735149, PMID:10704459]"}
{"concept_id": "C1523326", "aliases": ["NK T-cell proliferation", "NK T lymphocyte proliferation", "natural T cell proliferation", "NK T-lymphocyte proliferation", "NKT cell proliferation", "NT cell proliferation", "natural killer T cell proliferation"], "types": ["T043"], "canonical_name": "NK T cell proliferation", "definition": "The expansion of a NK T cell population by cell division. [GOC:add, ISBN:0781735149, PMID:10704459]"}
{"concept_id": "C1523327", "aliases": ["complement cascade, lectin pathway"], "types": ["T044"], "canonical_name": "complement activation, lectin pathway", "definition": "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523328", "aliases": ["regulation of complement cascade, lectin pathway"], "types": ["T043"], "canonical_name": "regulation of complement activation, lectin pathway", "definition": "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523329", "aliases": ["down regulation of complement activation, lectin pathway", "downregulation of complement activation, lectin pathway", "negative regulation of complement cascade, lectin pathway", "down-regulation of complement activation, lectin pathway"], "types": ["T043"], "canonical_name": "negative regulation of complement activation, lectin pathway", "definition": "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523330", "aliases": ["positive regulation of complement cascade, lectin pathway", "upregulation of complement activation, lectin pathway", "up-regulation of complement activation, lectin pathway", "up regulation of complement activation, lectin pathway"], "types": ["T043"], "canonical_name": "positive regulation of complement activation, lectin pathway", "definition": "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523332", "aliases": [], "types": ["T044"], "canonical_name": "zymosan binding"}
{"concept_id": "C1523333", "aliases": [], "types": ["T044"], "canonical_name": "polysaccharide receptor activity"}
{"concept_id": "C1523334", "aliases": [], "types": ["T044"], "canonical_name": "zymosan receptor activity"}
{"concept_id": "C1523335", "aliases": ["lipopolysaccharide receptor activity", "LPS receptor activity"], "types": ["T044"], "canonical_name": "lipopolysaccharide immune receptor activity", "definition": "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. [PMID:14609719, PMID:15379975]"}
{"concept_id": "C1523336", "aliases": ["LAM binding"], "types": ["T044"], "canonical_name": "lipoarabinomannan binding", "definition": "Binding to lipoarabinomannan. [PMID:10586073]"}
{"concept_id": "C1523337", "aliases": ["LAM receptor activity", "lipoarabinomannan receptor activity"], "types": ["T044"], "canonical_name": "lipoarabinomannan immune receptor activity", "definition": "Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response. [PMID:10586073]"}
{"concept_id": "C1523338", "aliases": [], "types": ["T040"], "canonical_name": "response to yeast", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. [PMID:14707091]"}
{"concept_id": "C1523339", "aliases": [], "types": ["T040"], "canonical_name": "Mullerian duct regression", "definition": "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos. [GOC:dph, PMID:12368913]"}
{"concept_id": "C1523340", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside binding", "definition": "Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. [GOC:hjd]"}
{"concept_id": "C1523341", "aliases": [], "types": ["T044"], "canonical_name": "purine nucleoside binding", "definition": "Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. [GOC:hjd]"}
{"concept_id": "C1523342", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine nucleoside binding", "definition": "Binding to a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose. [GOC:hjd]"}
{"concept_id": "C1523343", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell development", "definition": "The progression of an endothelial cell over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C1523344", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell morphogenesis", "definition": "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C1523345", "aliases": ["selenium compound metabolism", "selenium metabolic process", "selenium metabolism"], "types": ["T044"], "canonical_name": "selenium compound metabolic process", "definition": "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine. [PMID:12730456]"}
{"concept_id": "C1523346", "aliases": ["alpha-N-acetylglucosaminyltransferase I activity", "alpha-1,4-N-acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity", "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "alpha1,4-N-acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan. [EC:2.4.1.223, RHEA:16221]", "canonical_name": "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"}
{"concept_id": "C1523347", "aliases": [], "types": ["T038"], "canonical_name": "liver development", "definition": "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. [GOC:add, ISBN:068340007X]"}
{"concept_id": "C1523348", "aliases": [], "types": ["T026"], "canonical_name": "phagocytic cup", "definition": "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. [PMID:10358769]"}
{"concept_id": "C1523349", "aliases": ["fetal placenta development"], "types": ["T038"], "canonical_name": "embryonic placenta development", "definition": "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X]"}
{"concept_id": "C1523350", "aliases": ["decidua development"], "types": ["T038"], "canonical_name": "maternal placenta development", "definition": "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X]"}
{"concept_id": "C1523351", "aliases": [], "types": ["T040"], "canonical_name": "tissue homeostasis", "definition": "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. [GOC:add, GOC:isa_complete]"}
{"concept_id": "C1523358", "aliases": ["regulation of cytolysis in other organism", "regulation of cytolysis of cells of another organism"], "types": ["T043"], "canonical_name": "regulation of cytolysis in another organism", "definition": "Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism. [GOC:ai]"}
{"concept_id": "C1523361", "aliases": ["activation of membrane attack complex", "membrane attack complex formation", "MAC assembly", "MAC formation", "activation of MAC"], "types": ["T043"], "definition": "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis. [GOC:add, ISBN:0781735149]", "canonical_name": "membrane attack complex assembly"}
{"concept_id": "C1523363", "aliases": ["killing of cells of other organism"], "types": ["T040"], "canonical_name": "killing of cells of another organism", "definition": "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. [GOC:add]"}
{"concept_id": "C1523364", "aliases": ["immune cell mediated cytotoxicity", "immune cell mediated cell killing", "leucocyte mediated cytotoxicity", "immune cell mediated cell death"], "types": ["T043"], "canonical_name": "leukocyte mediated cytotoxicity", "definition": "The directed killing of a target cell by a leukocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:11911826]"}
{"concept_id": "C1523365", "aliases": ["regulation of immune cell mediated cell killing", "regulation of leucocyte mediated cytotoxicity", "regulation of immune cell mediated cytotoxicity", "regulation of immune cell mediated cell death"], "types": ["T043"], "canonical_name": "regulation of leukocyte mediated cytotoxicity", "definition": "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. [GOC:add, ISBN:0781735149, PMID:11911826]"}
{"concept_id": "C1523366", "aliases": ["downregulation of leukocyte mediated cytotoxicity", "down regulation of leukocyte mediated cytotoxicity", "negative regulation of leucocyte mediated cytotoxicity", "down-regulation of leukocyte mediated cytotoxicity", "negative regulation of immune cell mediated cytotoxicity"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte mediated cytotoxicity", "definition": "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity. [GOC:add, ISBN:0781735149, PMID:11911826]"}
{"concept_id": "C1523367", "aliases": ["up-regulation of leukocyte mediated cytotoxicity", "up regulation of leukocyte mediated cytotoxicity", "positive regulation of immune cell mediated cytotoxicity", "upregulation of leukocyte mediated cytotoxicity", "positive regulation of leucocyte mediated cytotoxicity"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte mediated cytotoxicity", "definition": "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity. [GOC:add, ISBN:0781735149, PMID:11911826]"}
{"concept_id": "C1523368", "aliases": ["T-lymphocyte mediated cytotoxicity", "T-cell mediated cell killing", "T-cell mediated cell death", "T cell mediated cell death", "T-cell mediated apoptosis", "T cell mediated apoptosis", "T lymphocyte mediated cytotoxicity", "T-cell mediated cytotoxicity", "T cell mediated cell killing"], "types": ["T043"], "canonical_name": "T cell mediated cytotoxicity", "definition": "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826]"}
{"concept_id": "C1523369", "aliases": ["regulation of T-cell mediated cell killing", "regulation of T-lymphocyte mediated cytotoxicity", "regulation of T cell mediated apoptosis", "regulation of T-cell mediated apoptosis", "regulation of T cell mediated cell killing", "regulation of T lymphocyte mediated cytotoxicity", "regulation of T-cell mediated cell death", "regulation of T-cell mediated cytotoxicity", "regulation of T cell mediated cell death"], "types": ["T043"], "canonical_name": "regulation of T cell mediated cytotoxicity", "definition": "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523370", "aliases": ["down regulation of T cell mediated cytotoxicity", "negative regulation of T-lymphocyte mediated cytotoxicity", "downregulation of T cell mediated cytotoxicity", "negative regulation of T-cell mediated cell death", "negative regulation of T cell mediated cell killing", "negative regulation of T cell mediated cell death", "negative regulation of T-cell mediated cytotoxicity", "negative regulation of T-cell mediated cell killing", "down-regulation of T cell mediated cytotoxicity", "negative regulation of T cell mediated apoptosis", "negative regulation of T lymphocyte mediated cytotoxicity", "negative regulation of T-cell mediated apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of T cell mediated cytotoxicity", "definition": "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523371", "aliases": ["positive regulation of T-cell mediated cytotoxicity", "positive regulation of T cell mediated cell death", "positive regulation of T-cell mediated cell killing", "positive regulation of T-cell mediated cell death", "positive regulation of T-cell mediated apoptosis", "up regulation of T cell mediated cytotoxicity", "up-regulation of T cell mediated cytotoxicity", "positive regulation of T lymphocyte mediated cytotoxicity", "positive regulation of T cell mediated cell killing", "positive regulation of T-lymphocyte mediated cytotoxicity", "upregulation of T cell mediated cytotoxicity", "positive regulation of T cell mediated apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of T cell mediated cytotoxicity", "definition": "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523372", "aliases": [], "types": ["T026"], "definition": "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. [GOC:add, PMID:12019563]", "canonical_name": "photoreceptor inner segment"}
{"concept_id": "C1523373", "aliases": [], "types": ["T044"], "canonical_name": "farnesylated protein binding", "definition": "Binding to a farnesylated protein. [GOC:add, PMID:14555765]"}
{"concept_id": "C1523374", "aliases": [], "types": ["T043"], "canonical_name": "regulation of receptor recycling", "definition": "Any process that modulates the frequency, rate, or extent of receptor recycling. [GOC:add]"}
{"concept_id": "C1523375", "aliases": ["down-regulation of receptor recycling", "down regulation of receptor recycling", "downregulation of receptor recycling"], "types": ["T044"], "canonical_name": "negative regulation of receptor recycling", "definition": "Any process that stops, prevents, or reduces the rate of receptor recycling. [GOC:add]"}
{"concept_id": "C1523376", "aliases": ["up regulation of receptor recycling", "up-regulation of receptor recycling", "upregulation of receptor recycling"], "types": ["T044"], "canonical_name": "positive regulation of receptor recycling", "definition": "Any process that activates or increases the frequency, rate or extent of receptor recycling. [GOC:add]"}
{"concept_id": "C1523377", "aliases": ["B-1 B lymphocyte homeostasis", "B-1 B-cell homeostasis", "B-1 B-lymphocyte homeostasis"], "types": ["T043"], "canonical_name": "B-1 B cell homeostasis", "definition": "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523378", "aliases": ["B-1 B lymphocyte differentiation", "B-1 B-cell differentiation", "B-1 B-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "B-1 B cell differentiation", "definition": "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523379", "aliases": ["regulation of B-1 B lymphocyte differentiation", "regulation of B-1 B-cell differentiation", "regulation of B-1 B-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of B-1 B cell differentiation", "definition": "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523380", "aliases": ["downregulation of B-1 B cell differentiation", "down-regulation of B-1 B cell differentiation", "negative regulation of B-1 B-lymphocyte differentiation", "negative regulation of B-1 B lymphocyte differentiation", "down regulation of B-1 B cell differentiation", "negative regulation of B-1 B-cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of B-1 B cell differentiation", "definition": "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523381", "aliases": ["positive regulation of B-1 B lymphocyte differentiation", "up-regulation of B-1 B cell differentiation", "up regulation of B-1 B cell differentiation", "positive regulation of B-1 B-cell differentiation", "positive regulation of B-1 B-lymphocyte differentiation", "upregulation of B-1 B cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of B-1 B cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1523382", "aliases": [], "types": ["T044"], "canonical_name": "complement component C5a receptor activity", "definition": "Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1523383", "aliases": ["HER2 receptor ligand", "Neu receptor ligand"], "types": ["T044"], "canonical_name": "ErbB-2 class receptor ligand"}
{"concept_id": "C1523385", "aliases": ["mitochondrial pyruvate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "mitochondrial pyruvate dehydrogenase complex", "definition": "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094]"}
{"concept_id": "C1523386", "aliases": [], "types": ["T044"], "canonical_name": "patched ligand processing"}
{"concept_id": "C1523388", "aliases": ["ribitol degradation to xylulose 5-phosphate", "ribitol breakdown to xylulose 5-phosphate"], "types": ["T044"], "canonical_name": "ribitol catabolic process to xylulose 5-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate. [MetaCyc:RIBITOLUTIL-PWY]"}
{"concept_id": "C1523389", "aliases": ["mitochondrial tricarboxylic acid cycle enzyme complex location"], "types": ["T026"], "canonical_name": "mitochondrial tricarboxylic acid cycle enzyme complex", "definition": "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1523390", "aliases": [], "types": ["T040"], "canonical_name": "embryonic limb morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. [GOC:bf, GOC:jl, ISBN:0395825172]"}
{"concept_id": "C1523391", "aliases": ["embryonic genital morphogenesis"], "types": ["T040"], "canonical_name": "embryonic genitalia morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized. [GOC:bf]"}
{"concept_id": "C1523392", "aliases": ["ubiquitin-dependent SMAD protein degradation", "ubiquitin-dependent SMAD protein catabolism", "ubiquitin-dependent SMAD protein breakdown"], "types": ["T044"], "canonical_name": "ubiquitin-dependent SMAD protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome. [GOC:go_curators]"}
{"concept_id": "C1523393", "aliases": [], "types": ["T045"], "canonical_name": "non-intein-mediated protein splicing", "definition": "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins. [GOC:mah]"}
{"concept_id": "C1523394", "aliases": [], "types": ["T040"], "canonical_name": "olfactory placode formation", "definition": "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. [GOC:dgh]"}
{"concept_id": "C1523395", "aliases": ["tetratricopeptide repeat domain binding"], "types": ["T044"], "canonical_name": "TPR domain binding", "definition": "Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. [GOC:mah]"}
{"concept_id": "C1523396", "aliases": [], "types": ["T040"], "canonical_name": "response to deep water", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle. [GOC:mah]"}
{"concept_id": "C1523397", "aliases": ["paranodal junction formation", "paranodal junction biosynthesis", "paranodal axoglial junction formation"], "types": ["T043"], "canonical_name": "paranodal junction assembly", "definition": "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier. [PMID:14715942]"}
{"concept_id": "C1523399", "aliases": ["Smc5-Smc6 complex location"], "types": ["T026"], "canonical_name": "Smc5-Smc6 complex", "definition": "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152]"}
{"concept_id": "C1523400", "aliases": ["otocyst biosynthesis", "otocyst formation"], "types": ["T042"], "canonical_name": "otic vesicle formation", "definition": "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear. [GOC:dgh]"}
{"concept_id": "C1523401", "aliases": ["MHB development", "isthmic organizer development", "midbrain-hindbrain orgainizer development", "isthmomesencephalic boundary development", "isthmus development"], "types": ["T042"], "canonical_name": "midbrain-hindbrain boundary development", "definition": "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. [GOC:dgh]"}
{"concept_id": "C1523402", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine O-acetylation", "definition": "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine. [PMID:489587, PMID:7309355, RESID:AA0364]"}
{"concept_id": "C1523403", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine acetylation", "definition": "The acetylation of peptidyl-serine. [GOC:mah]"}
{"concept_id": "C1523404", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine", "definition": "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues. [PMID:9631087, RESID:AA0183]"}
{"concept_id": "C1523405", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine", "definition": "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues. [PMID:12623015, RESID:AA0365]"}
{"concept_id": "C1523406", "aliases": [], "types": ["T044"], "canonical_name": "metal incorporation into metallo-oxygen cluster", "definition": "The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate. [GOC:jsg]"}
{"concept_id": "C1523407", "aliases": [], "types": ["T044"], "canonical_name": "manganese incorporation into metallo-oxygen cluster", "definition": "The incorporation of manganese into a metallo-oxygen cluster. [GOC:jsg]"}
{"concept_id": "C1523408", "aliases": [], "types": ["T044"], "canonical_name": "calcium incorporation into metallo-oxygen cluster", "definition": "The incorporation of calcium into a metallo-oxygen cluster. [GOC:jsg]"}
{"concept_id": "C1523409", "aliases": [], "types": ["T044"], "canonical_name": "calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide", "definition": "The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site. [PMID:14764885, RESID:AA0366]"}
{"concept_id": "C1523410", "aliases": [], "types": ["T044"], "canonical_name": "manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide", "definition": "The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site. [PMID:14764885, RESID:AA0366]"}
{"concept_id": "C1523412", "aliases": ["ADPG pyrophosphorylase complex location"], "types": ["T026"], "canonical_name": "ADPG pyrophosphorylase complex", "definition": "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits. [GOC:tb, PMID:9680965]"}
{"concept_id": "C1523413", "aliases": ["homotetrameric ADPG pyrophosphorylase complex location"], "types": ["T026"], "canonical_name": "homotetrameric ADPG pyrophosphorylase complex", "definition": "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1523414", "aliases": ["heterotetrameric ADPG pyrophosphorylase complex location"], "types": ["T026"], "canonical_name": "heterotetrameric ADPG pyrophosphorylase complex", "definition": "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1523415", "aliases": ["amyloplast ADPG pyrophosphorylase complex location"], "types": ["T026"], "canonical_name": "amyloplast ADPG pyrophosphorylase complex", "definition": "An ADPG pyrophosphorylase complex found in the amyloplast. [GOC:mah]"}
{"concept_id": "C1523416", "aliases": ["chloroplast ADPG pyrophosphorylase complex location"], "types": ["T026"], "canonical_name": "chloroplast ADPG pyrophosphorylase complex", "definition": "An ADPG pyrophosphorylase complex found in the chloroplast. [GOC:mah]"}
{"concept_id": "C1523417", "aliases": ["connecting collagen", "anchoring collagen complex location", "linking collagen"], "types": ["T026"], "canonical_name": "anchoring collagen complex", "definition": "Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures. [ISBN:0721639976]"}
{"concept_id": "C1523418", "aliases": ["hexagonal network-forming collagen"], "types": ["T026"], "definition": "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers assemble into a sheet. [PMID:7188361]", "canonical_name": "sheet-forming collagen trimer"}
{"concept_id": "C1523419", "aliases": ["MACIT"], "types": ["T026"], "canonical_name": "transmembrane collagen trimer", "definition": "Any collagen trimer that passes through a lipid bilayer membrane. [ISBN:0721639976]"}
{"concept_id": "C1523420", "aliases": [], "types": ["T040"], "canonical_name": "response to long-day photoperiod", "definition": "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark. [GOC:pj]"}
{"concept_id": "C1523421", "aliases": [], "types": ["T040"], "canonical_name": "response to short-day photoperiod", "definition": "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light. [GOC:pj]"}
{"concept_id": "C1523422", "aliases": [], "types": ["T044"], "canonical_name": "chloroplast targeting sequence binding", "definition": "Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast. [GOC:mah]"}
{"concept_id": "C1523423", "aliases": ["ER signal peptide binding"], "types": ["T044"], "canonical_name": "endoplasmic reticulum signal peptide binding", "definition": "Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C1523424", "aliases": ["mitochondrial targeting sequence binding"], "types": ["T044"], "canonical_name": "mitochondrion targeting sequence binding", "definition": "Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion. [GOC:mah]"}
{"concept_id": "C1523425", "aliases": [], "types": ["T044"], "canonical_name": "DDEL sequence binding", "definition": "Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C1523426", "aliases": [], "types": ["T044"], "canonical_name": "protein tyrosine phosphatase activity, via thiol-phosphate intermediate", "definition": "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate. [GOC:hjd]"}
{"concept_id": "C1523427", "aliases": [], "types": ["T044"], "canonical_name": "protein tyrosine phosphatase activity, metal-dependent", "definition": "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions. [GOC:mah]"}
{"concept_id": "C1523428", "aliases": ["regulation of vascular endothelial growth factor receptor signalling pathway", "regulation of VEGF receptor signalling pathway", "regulation of VEGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of vascular endothelial growth factor receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. [GOC:dgh]"}
{"concept_id": "C1523429", "aliases": ["negative regulation of vascular endothelial growth factor receptor signalling pathway", "down regulation of vascular endothelial growth factor receptor signaling pathway", "down-regulation of vascular endothelial growth factor receptor signaling pathway", "negative regulation of VEGF receptor signaling pathway", "downregulation of vascular endothelial growth factor receptor signaling pathway", "negative regulation of VEGF receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of vascular endothelial growth factor receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. [GOC:dgh]"}
{"concept_id": "C1523430", "aliases": ["up regulation of vascular endothelial growth factor receptor signaling pathway", "positive regulation of vascular endothelial growth factor receptor signalling pathway", "positive regulation of VEGF receptor signaling pathway", "positive regulation of VEGF receptor signalling pathway", "up-regulation of vascular endothelial growth factor receptor signaling pathway", "upregulation of vascular endothelial growth factor receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of vascular endothelial growth factor receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. [GOC:dgh]"}
{"concept_id": "C1523431", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of actin cytoskeleton polarity", "definition": "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures. [GOC:mah]"}
{"concept_id": "C1523432", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of microtubule cytoskeleton polarity", "definition": "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. [GOC:mah]"}
{"concept_id": "C1523433", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of cytoskeleton polarity", "definition": "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. [GOC:mah]"}
{"concept_id": "C1523434", "aliases": ["astral microtubule organization and biogenesis", "astral microtubule organisation"], "types": ["T043"], "canonical_name": "astral microtubule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles. [GOC:mah]"}
{"concept_id": "C1523436", "aliases": ["K ion binding"], "types": ["T044"], "canonical_name": "potassium ion binding", "definition": "Binding to a potassium ion (K+). [GOC:mah]"}
{"concept_id": "C1523437", "aliases": ["GatCAB", "GatFAB", "AdT", "glutamyl-tRNA(Gln) amidotransferase complex location"], "types": ["T026"], "definition": "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms. [GOC:mlg]", "canonical_name": "glutamyl-tRNA(Gln) amidotransferase complex"}
{"concept_id": "C1523438", "aliases": [], "types": ["T045"], "canonical_name": "Tat protein binding", "definition": "Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. [GOC:mah, PMID:9094689]"}
{"concept_id": "C1523439", "aliases": ["RITS complex location"], "types": ["T026"], "canonical_name": "RITS complex", "definition": "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing. [PMID:14704433]"}
{"concept_id": "C1523440", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine", "definition": "The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link. [RESID:AA0367]"}
{"concept_id": "C1523441", "aliases": [], "types": ["T044"], "canonical_name": "peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine", "definition": "The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link. [PDB:1NGK, PMID:12719529, RESID:AA0368]"}
{"concept_id": "C1523442", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine", "definition": "The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine. [PMID:10978343, RESID:AA0369]"}
{"concept_id": "C1523443", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine", "definition": "The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine. [PMID:10978343, RESID:AA0370]"}
{"concept_id": "C1523445", "aliases": [], "types": ["T044"], "canonical_name": "plasma membrane electron transport, NADH to quinone", "definition": "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase. [GOC:mah, GOC:sd]"}
{"concept_id": "C1523450", "aliases": ["retrograde protein transport, endoplasmic reticulum to cytosol", "protein dislocation from ER", "protein retrotranslocation, ER to cytosol"], "types": ["T043"], "canonical_name": "retrograde protein transport, ER to cytosol", "definition": "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. [PMID:11994744]"}
{"concept_id": "C1523451", "aliases": [], "types": ["T044"], "canonical_name": "receptor tyrosine kinase binding", "definition": "Binding to a receptor that possesses protein tyrosine kinase activity. [GOC:mah]"}
{"concept_id": "C1523453", "aliases": ["MoO4 ion binding"], "types": ["T044"], "canonical_name": "molybdate ion binding", "definition": "Binding to a molybdate ion (MoO4 2-). [GOC:mlg]"}
{"concept_id": "C1523454", "aliases": ["TPP transport", "thiamin diphosphate transport", "thiamin pyrophosphate transport", "thiamine diphosphate transport", "thiamine pyrophosphate transport"], "types": ["T043"], "canonical_name": "thiamine pyrophosphate transmembrane transport", "definition": "The process in which thiamine pyrophosphate is transported across a membrane. [GOC:mlg]"}
{"concept_id": "C1523455", "aliases": ["vitamin B1 binding", "thiamin binding"], "types": ["T044"], "canonical_name": "thiamine binding", "definition": "Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:mlg]"}
{"concept_id": "C1523456", "aliases": ["thiamin pyrophosphate binding", "TPP binding", "diphosphothiamin binding", "aneurine pyrophosphate binding", "cocarboxylase binding"], "types": ["T044"], "canonical_name": "thiamine pyrophosphate binding", "definition": "Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. [GOC:mlg]"}
{"concept_id": "C1523457", "aliases": [], "types": ["T044"], "canonical_name": "taurine binding", "definition": "Binding to taurine. [GOC:mlg]"}
{"concept_id": "C1523458", "aliases": ["alpha-glucan metabolism"], "types": ["T044"], "canonical_name": "alpha-glucan metabolic process", "definition": "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds. [GOC:mah]"}
{"concept_id": "C1523459", "aliases": ["alpha-glucan biosynthesis", "alpha-glucan formation", "alpha-glucan synthesis", "alpha-glucan anabolism"], "types": ["T044"], "canonical_name": "alpha-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds. [GOC:mah]"}
{"concept_id": "C1523460", "aliases": ["alpha-glucan degradation", "alpha-glucan breakdown", "alpha-glucan catabolism"], "types": ["T044"], "canonical_name": "alpha-glucan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alpha-glucans. [GOC:mah]"}
{"concept_id": "C1523461", "aliases": [], "types": ["T026"], "canonical_name": "cortical microtubule cytoskeleton", "definition": "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane. [GOC:mah]"}
{"concept_id": "C1523462", "aliases": ["adventurous gliding movement"], "types": ["T043"], "canonical_name": "adventurous gliding motility", "definition": "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime. [GOC:mlg, PMID:11967173]"}
{"concept_id": "C1523463", "aliases": ["mispair binding", "mispaired DNA binding"], "types": ["T045"], "canonical_name": "mismatched DNA binding", "definition": "Binding to a double-stranded DNA region containing one or more mismatches. [GOC:mah]"}
{"concept_id": "C1523464", "aliases": [], "types": ["T044"], "canonical_name": "kininogen binding", "definition": "Binding to a kininogen, a kinin precursor. [GOC:mah, PMID:9520414]"}
{"concept_id": "C1523465", "aliases": ["HMW kininogen binding", "HK binding"], "types": ["T044"], "canonical_name": "high molecular weight kininogen binding", "definition": "Binding to a kininogen of high molecular mass. [GOC:mah, PMID:9520414]"}
{"concept_id": "C1523466", "aliases": ["LK binding", "LMW kininogen binding"], "types": ["T044"], "canonical_name": "low molecular weight kininogen binding", "definition": "Binding to a kininogen of low molecular mass. [GOC:mah, PMID:9520414]"}
{"concept_id": "C1523467", "aliases": [], "types": ["T044"], "canonical_name": "high molecular weight kininogen receptor binding", "definition": "Binding to a high molecular weight kininogen receptor. [GOC:mah]"}
{"concept_id": "C1523468", "aliases": ["high molecular weight kininogen receptor complex location"], "types": ["T026"], "canonical_name": "high molecular weight kininogen receptor complex", "definition": "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins. [GOC:mah, PMID:11290596]"}
{"concept_id": "C1523469", "aliases": ["horsetail movement", "HNM", "horsetail nuclear movement"], "types": ["T043"], "definition": "Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein. [GOC:vw, PMID:16111942, PMID:9572142]", "canonical_name": "dynein-driven meiotic oscillatory nuclear movement"}
{"concept_id": "C1523470", "aliases": ["intraflagellar transport particle", "intraflagellar transport complex location", "intraflagellar transport complex"], "types": ["T026"], "canonical_name": "intraciliary transport particle", "definition": "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166]"}
{"concept_id": "C1523471", "aliases": ["intraflagellar transport complex A location", "intraflagellar transport complex A", "intraflagellar transport particle A"], "types": ["T026"], "canonical_name": "intraciliary transport particle A", "definition": "The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa. [GOC:cilia, GOC:kmv, PMID:14570576]"}
{"concept_id": "C1523472", "aliases": ["intraflagellar transport particle B", "intraflagellar transport complex B location", "intraflagellar transport complex B", "IFT complex B location", "IFT B complex location", "IFT complex B", "IFT B complex"], "types": ["T026"], "canonical_name": "intraciliary transport particle B", "definition": "The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. [GOC:cilia, GOC:kmv, PMID:14570576, PMID:19253336]"}
{"concept_id": "C1523473", "aliases": ["axonemal heterotrimeric kinesin-II complex location"], "types": ["T026"], "canonical_name": "axonemal heterotrimeric kinesin-II complex", "definition": "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme. [GOC:kmv, PMID:14570576]"}
{"concept_id": "C1523474", "aliases": ["hydrolysis of primary cell septum", "primary cell septum hydrolysis"], "types": ["T043"], "canonical_name": "primary cell septum disassembly", "definition": "Dissolution of the primary septum during cell separation. [PMID:12665550]"}
{"concept_id": "C1523475", "aliases": ["hydrolysis of edging of cell septum", "hydrolysis of cell septum edging", "cell septum edging hydrolysis"], "types": ["T043"], "canonical_name": "cell septum edging catabolic process", "definition": "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation. [GOC:mah, PMID:15194814]"}
{"concept_id": "C1523477", "aliases": [], "types": ["T043"], "canonical_name": "regulation of centriole-centriole cohesion", "definition": "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker. [PMID:11076968]"}
{"concept_id": "C1523478", "aliases": [], "types": ["T026"], "canonical_name": "linear element", "definition": "A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex. [DOI:10.2323/jgam.28.263, GOC:jb, PMID:12665553, PMID:30640914]"}
{"concept_id": "C1523479", "aliases": [], "types": ["T043"], "canonical_name": "linear element formation"}
{"concept_id": "C1523480", "aliases": [], "types": ["T040"], "canonical_name": "response to caffeine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. [GOC:ef, GOC:mah]"}
{"concept_id": "C1523481", "aliases": [], "types": ["T043"], "canonical_name": "response to brefeldin A", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus. [GOC:mah]"}
{"concept_id": "C1523482", "aliases": [], "types": ["T026"], "canonical_name": "actin rod", "definition": "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Actin rod structures are found in diverse organisms, having been observed in spores of Dictyostelium discoideum, Drosophila melanogaster oocytes, as well as in numerous animal cells under stress conditions. [GOC:kp, GOC:krc, PMID:11858703, PMID:19459188, PMID:22623727, PMID:24813767, PMID:27535426, PMID:7820870]"}
{"concept_id": "C1523483", "aliases": [], "types": ["T026"], "canonical_name": "actin tubule", "definition": "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together. [GOC:kp]"}
{"concept_id": "C1523484", "aliases": ["potassium ion-transporting ATPase complex location", "Kdp system complex", "Kdp system complex location"], "types": ["T026"], "canonical_name": "potassium ion-transporting ATPase complex", "definition": "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex. [PMID:10608856, PMID:9858692]"}
{"concept_id": "C1523485", "aliases": ["filamin C binding", "filamin B binding", "filamin-B binding", "filamin-C binding"], "types": ["T044"], "canonical_name": "filamin binding", "definition": "Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. [GOC:mah, PMID:11336782]"}
{"concept_id": "C1523486", "aliases": ["alpha-filamin binding", "ABP-280 binding"], "types": ["T044"], "canonical_name": "filamin-1 binding"}
{"concept_id": "C1523489", "aliases": ["plastid ADPG pyrophosphorylase complex location"], "types": ["T026"], "canonical_name": "plastid ADPG pyrophosphorylase complex", "definition": "An ADPG pyrophosphorylase complex found in a plastid. [GOC:mah]"}
{"concept_id": "C1523491", "aliases": ["Ino80 complex", "INO80 chromatin remodeling complex", "Ino80 complex location"], "types": ["T026"], "definition": "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity. [GOC:jh, GOC:rb, PMID:19355820]", "canonical_name": "INO80 chromatin remodeling complex location"}
{"concept_id": "C1523492", "aliases": [], "types": ["T044"], "canonical_name": "troponin I binding", "definition": "Binding to troponin I, the inhibitory subunit of the troponin complex. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1523493", "aliases": [], "types": ["T044"], "canonical_name": "troponin T binding", "definition": "Binding to troponin T, the tropomyosin-binding subunit of the troponin complex. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C1523495", "aliases": [], "types": ["T038"], "canonical_name": "pancreas development", "definition": "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. [GOC:cvs]"}
{"concept_id": "C1523496", "aliases": [], "types": ["T038"], "canonical_name": "exocrine pancreas development", "definition": "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. [GOC:cvs]"}
{"concept_id": "C1523497", "aliases": [], "types": ["T038"], "canonical_name": "endocrine pancreas development", "definition": "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. [GOC:cvs]"}
{"concept_id": "C1523498", "aliases": ["mitochondrial mRNA editing complex location", "mitochondrial editosome"], "types": ["T026"], "canonical_name": "mitochondrial mRNA editing complex", "definition": "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates. [GOC:mah, PMID:12139607]"}
{"concept_id": "C1523499", "aliases": ["plastid mRNA editing complex location", "plastid editosome"], "types": ["T026"], "canonical_name": "plastid mRNA editing complex", "definition": "An mRNA editing complex found in a plastid. [GOC:mah]"}
{"concept_id": "C1523500", "aliases": ["interphase MTOC", "iMTOC", "interphase microtubule organising center"], "types": ["T026"], "canonical_name": "interphase microtubule organizing center", "definition": "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus. [PMID:15068790]"}
{"concept_id": "C1523501", "aliases": ["nuclear migration, microfilament-mediated"], "types": ["T043"], "canonical_name": "nuclear migration along microfilament", "definition": "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. [GOC:mah]"}
{"concept_id": "C1523502", "aliases": ["microtubule organising center organisation", "microtubule organizing center organization and biogenesis"], "types": ["T043"], "canonical_name": "microtubule organizing center organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1523503", "aliases": ["interphase microtubule organizing centre assembly", "interphase microtubule organising center formation", "interphase microtubule organizing center biogenesis", "interphase microtubule organising center biosynthesis"], "types": ["T043"], "canonical_name": "interphase microtubule organizing center assembly", "definition": "The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center. [GOC:mah, PMID:15068790]"}
{"concept_id": "C1523504", "aliases": ["equatorial microtubule organising center disassembly"], "types": ["T043"], "canonical_name": "equatorial microtubule organizing center disassembly", "definition": "The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis. [GOC:mah, PMID:15068790]"}
{"concept_id": "C1523505", "aliases": ["glutamate synthase complex location"], "types": ["T026"], "canonical_name": "glutamate synthase complex", "definition": "A complex that possesses glutamate synthase activity. [GOC:mah]"}
{"concept_id": "C1523506", "aliases": ["glutamate synthase complex location (NADH)"], "types": ["T026"], "canonical_name": "glutamate synthase complex (NADH)", "definition": "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity. [GOC:jl, PMID:7047525]"}
{"concept_id": "C1523507", "aliases": ["regulation of septation initiation network", "regulation of septation initiation signalling", "regulation of septation initiation signaling cascade"], "types": ["T044"], "canonical_name": "regulation of septation initiation signaling", "definition": "Any process that modulates the frequency, rate or extent of septation initiation signaling. [GOC:mah]"}
{"concept_id": "C1523510", "aliases": ["actomyosin structure organisation", "actomyosin organization", "actomyosin structure organization and biogenesis"], "types": ["T043"], "canonical_name": "actomyosin structure organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1523511", "aliases": [], "types": ["T043"], "canonical_name": "myosin polymerization or depolymerization"}
{"concept_id": "C1523512", "aliases": [], "types": ["T043"], "canonical_name": "myosin polymerization"}
{"concept_id": "C1523513", "aliases": [], "types": ["T043"], "canonical_name": "myosin depolymerization"}
{"concept_id": "C1523514", "aliases": [], "types": ["T043"], "canonical_name": "myosin II polymerization"}
{"concept_id": "C1523515", "aliases": [], "types": ["T043"], "canonical_name": "myosin II depolymerization"}
{"concept_id": "C1523516", "aliases": [], "types": ["T043"], "canonical_name": "myosin II polymerization or depolymerization"}
{"concept_id": "C1523517", "aliases": [], "types": ["T044"], "canonical_name": "O-glycan processing, core 5", "definition": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc. [GOC:mah, GOC:pr, PMID:10580130]"}
{"concept_id": "C1523518", "aliases": [], "types": ["T044"], "canonical_name": "O-glycan processing, core 6", "definition": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc. [GOC:mah, GOC:pr, PMID:10580130]"}
{"concept_id": "C1523519", "aliases": [], "types": ["T044"], "canonical_name": "O-glycan processing, core 7", "definition": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc. [GOC:mah, GOC:pr, PMID:10580130]"}
{"concept_id": "C1523520", "aliases": [], "types": ["T044"], "canonical_name": "O-glycan processing, core 8", "definition": "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc. [GOC:mah, GOC:pr, PMID:10580130]"}
{"concept_id": "C1523523", "aliases": ["RNA-mediated gene silencing"], "types": ["T045"], "canonical_name": "gene silencing by RNA", "definition": "A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. [PMID:15020054]"}
{"concept_id": "C1523524", "aliases": ["RNAi-like chromatin silencing", "small RNA-mediated heterochromatic silencing", "RNA interference-like chromatin silencing", "RNA-mediated chromatin silencing", "chromatin silencing by small RNA", "RNA-mediated transcriptional silencing", "RNAi-directed chromatin silencing"], "types": ["T045"], "canonical_name": "heterochromatin assembly by small RNA", "definition": "Assembly of heterochromatin, directed by small RNAs sharing sequence identity to the repressed region. [GOC:dph, GOC:mtg_lung, GOC:ns, PMID:19239886]"}
{"concept_id": "C1523525", "aliases": [], "types": ["T044"], "canonical_name": "programmed DNA elimination", "definition": "A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing. [GOC:mah, GOC:ns, PMID:18708581, PMID:24886889, PMID:32986476]"}
{"concept_id": "C1523528", "aliases": ["pri-miRNA processing", "primary miRNA modification", "primary microRNA processing"], "types": ["T045"], "canonical_name": "primary miRNA processing", "definition": "A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. [GOC:sl, PMID:15211354, PMID:25799998]"}
{"concept_id": "C1523529", "aliases": ["pre-microRNA processing"], "types": ["T045"], "canonical_name": "pre-miRNA processing", "definition": "A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. [GOC:sl, PMID:15211354]"}
{"concept_id": "C1523530", "aliases": [], "types": ["T045"], "canonical_name": "chromatin remodeling at centromere", "definition": "Dynamic structural changes in centromeric DNA. [GOC:mah]"}
{"concept_id": "C1523531", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone modification", "definition": "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone. [GOC:mah]"}
{"concept_id": "C1523532", "aliases": ["down regulation of histone modification", "downregulation of histone modification", "down-regulation of histone modification"], "types": ["T044"], "canonical_name": "negative regulation of histone modification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone. [GOC:mah]"}
{"concept_id": "C1523533", "aliases": ["upregulation of histone modification", "up regulation of histone modification", "up-regulation of histone modification"], "types": ["T044"], "canonical_name": "positive regulation of histone modification", "definition": "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone. [GOC:mah]"}
{"concept_id": "C1523534", "aliases": [], "types": ["T044"], "canonical_name": "histone deacetylation at centromere", "definition": "The removal of acetyl groups from histones in centromeric DNA. [GOC:mah]"}
{"concept_id": "C1523535", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone methylation", "definition": "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. [GOC:mah]"}
{"concept_id": "C1523536", "aliases": ["down-regulation of histone methylation", "downregulation of histone methylation", "down regulation of histone methylation"], "types": ["T044"], "canonical_name": "negative regulation of histone methylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones. [GOC:mah]"}
{"concept_id": "C1523537", "aliases": ["up regulation of histone methylation", "up-regulation of histone methylation", "upregulation of histone methylation"], "types": ["T044"], "canonical_name": "positive regulation of histone methylation", "definition": "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. [GOC:mah]"}
{"concept_id": "C1523538", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone deacetylation", "definition": "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. [GOC:mah]"}
{"concept_id": "C1523539", "aliases": ["down regulation of histone deacetylation", "down-regulation of histone deacetylation", "downregulation of histone deacetylation"], "types": ["T044"], "canonical_name": "negative regulation of histone deacetylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones. [GOC:mah]"}
{"concept_id": "C1523540", "aliases": ["up-regulation of histone deacetylation", "up regulation of histone deacetylation", "upregulation of histone deacetylation"], "types": ["T044"], "canonical_name": "positive regulation of histone deacetylation", "definition": "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. [GOC:mah]"}
{"concept_id": "C1523541", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone deacetylation at centromere", "definition": "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA. [GOC:mah]"}
{"concept_id": "C1523542", "aliases": ["down-regulation of histone deacetylation at centromere", "down regulation of histone deacetylation at centromere", "downregulation of histone deacetylation at centromere"], "types": ["T044"], "canonical_name": "negative regulation of histone deacetylation at centromere", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA. [GOC:mah]"}
{"concept_id": "C1523543", "aliases": ["upregulation of histone deacetylation at centromere", "up regulation of histone deacetylation at centromere", "up-regulation of histone deacetylation at centromere"], "types": ["T044"], "canonical_name": "positive regulation of histone deacetylation at centromere", "definition": "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA. [GOC:mah]"}
{"concept_id": "C1523544", "aliases": [], "types": ["T040"], "canonical_name": "hair follicle morphogenesis", "definition": "The process in which the anatomical structures of the hair follicle are generated and organized. [GOC:ln]"}
{"concept_id": "C1523545", "aliases": [], "types": ["T045"], "canonical_name": "intronic snoRNA processing", "definition": "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA. [GOC:vw]"}
{"concept_id": "C1523546", "aliases": [], "types": ["T044"], "canonical_name": "heat shock protein binding", "definition": "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. [GOC:mah, GOC:vw]"}
{"concept_id": "C1523547", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol 26-hydroxylase activity", "definition": "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol. [GOC:mah, PMID:950499]"}
{"concept_id": "C1523548", "aliases": ["nucleocytoplasmic shuttling complex location"], "types": ["T026"], "canonical_name": "nucleocytoplasmic shuttling complex"}
{"concept_id": "C1523550", "aliases": [], "types": ["T042"], "canonical_name": "embryonic camera-type eye morphogenesis", "definition": "The process in which the anatomical structures of the eye are generated and organized during embryonic development. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1523551", "aliases": ["post-embryonic camera-style eye morphogenesis"], "types": ["T042"], "canonical_name": "post-embryonic camera-type eye morphogenesis", "definition": "The process in which the anatomical structures of the eye are generated and organized during post-embryonic development. [GOC:jid, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1523552", "aliases": [], "types": ["T044"], "canonical_name": "histone deacetylase activity (H3-K14 specific)", "definition": "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. [PMID:28450737]"}
{"concept_id": "C1523554", "aliases": ["Nup84 complex", "Nup107-160 complex", "Nup107-120 complex", "Nup84 complex location", "Nup107-120 complex location", "Nup107-160 complex location"], "types": ["T026"], "canonical_name": "nuclear pore outer ring", "definition": "A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates). [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]"}
{"concept_id": "C1523556", "aliases": ["BLOC complex location", "BLOC-1 related complex location", "BLOC-1 related complex"], "types": ["T026"], "canonical_name": "BLOC complex", "definition": "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. [PMID:15102850, PMID:15261680]"}
{"concept_id": "C1523557", "aliases": ["BLOC-1 complex location"], "types": ["T026"], "canonical_name": "BLOC-1 complex", "definition": "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. [PMID:15102850]"}
{"concept_id": "C1523558", "aliases": ["BLOC-2 complex location"], "types": ["T026"], "canonical_name": "BLOC-2 complex", "definition": "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru. [PMID:12548288, PMID:14718540, PMID:15031569]"}
{"concept_id": "C1523559", "aliases": ["BLOC-3 complex location"], "types": ["T026"], "canonical_name": "BLOC-3 complex", "definition": "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins. [PMID:12756248]"}
{"concept_id": "C1523560", "aliases": ["nuclear mRNA catabolic process, deadenylation-independent decay", "mRNA catabolism, deadenylation-independent", "mRNA catabolic process, deadenylation-independent", "deadenylation-independent mRNA decay", "mRNA breakdown, deadenylation-independent decay", "mRNA catabolic process, deadenylylation-independent", "deadenylylation-independent mRNA decay", "mRNA degradation, deadenylation-independent decay", "mRNA catabolism, deadenylylation-independent", "mRNA catabolism, deadenylation-independent decay"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, deadenylation-independent decay", "definition": "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability. [GOC:krc, PMID:15225542, PMID:15225544]"}
{"concept_id": "C1523561", "aliases": ["deadenylylation-independent decapping"], "types": ["T045"], "canonical_name": "deadenylation-independent decapping of nuclear-transcribed mRNA", "definition": "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening. [GOC:krc, PMID:15225542, PMID:15225544]"}
{"concept_id": "C1523562", "aliases": ["hemocyte cell migration", "arthropod blood cell migration"], "types": ["T043"], "canonical_name": "hemocyte migration", "definition": "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo. [GOC:bf, GOC:mtg_sensu, PMID:12885551]"}
{"concept_id": "C1523563", "aliases": [], "types": ["T040"], "canonical_name": "appendage morphogenesis", "definition": "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. [ISBN:0582227089]"}
{"concept_id": "C1523565", "aliases": [], "types": ["T040"], "canonical_name": "embryonic appendage morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. [ISBN:0582227089]"}
{"concept_id": "C1523566", "aliases": [], "types": ["T040"], "canonical_name": "imaginal disc-derived appendage morphogenesis", "definition": "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism. [GOC:mtg_sensu, ISBN:0582227089]"}
{"concept_id": "C1523567", "aliases": [], "types": ["T040"], "canonical_name": "embryonic forelimb morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. [ISBN:0198612001]"}
{"concept_id": "C1523568", "aliases": [], "types": ["T040"], "canonical_name": "embryonic hindlimb morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. [ISBN:0198612001]"}
{"concept_id": "C1523569", "aliases": [], "types": ["T040"], "canonical_name": "embryonic arm morphogenesis"}
{"concept_id": "C1523570", "aliases": [], "types": ["T040"], "canonical_name": "embryonic pectoral fin morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. [GOC:dgh]"}
{"concept_id": "C1523571", "aliases": [], "types": ["T040"], "canonical_name": "embryonic pelvic fin morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. [GOC:dgh]"}
{"concept_id": "C1523572", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic appendage morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. [ISBN:0582227089]"}
{"concept_id": "C1523574", "aliases": ["embryonic unpaired fin morphogenesis"], "types": ["T040"], "canonical_name": "embryonic medial fin morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. [GOC:dgh]"}
{"concept_id": "C1523575", "aliases": [], "types": ["T040"], "canonical_name": "embryonic dorsal fin morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. [GOC:dgh]"}
{"concept_id": "C1523576", "aliases": [], "types": ["T040"], "canonical_name": "embryonic caudal fin morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion. [GOC:dgh]"}
{"concept_id": "C1523577", "aliases": [], "types": ["T040"], "canonical_name": "embryonic anal fin morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. [GOC:dgh]"}
{"concept_id": "C1523578", "aliases": ["post-embryonic genital morphogenesis"], "types": ["T040"], "canonical_name": "post-embryonic genitalia morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized. [GOC:bf]"}
{"concept_id": "C1523579", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic limb morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. [ISBN:0395825172]"}
{"concept_id": "C1523580", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic forelimb morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism. [GOC:bf]"}
{"concept_id": "C1523581", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic hindlimb morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized. [GOC:bf]"}
{"concept_id": "C1523582", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic pectoral fin morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. [GOC:dgh]"}
{"concept_id": "C1523583", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic pelvic fin morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. [GOC:dgh]"}
{"concept_id": "C1523584", "aliases": ["post-embryonic unpaired fin morphogenesis"], "types": ["T040"], "canonical_name": "post-embryonic medial fin morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. [GOC:dgh]"}
{"concept_id": "C1523585", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic caudal fin morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion. [GOC:dgh]"}
{"concept_id": "C1523586", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic dorsal fin morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. [GOC:dgh]"}
{"concept_id": "C1523587", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic anal fin morphogenesis", "definition": "The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. [GOC:dgh]"}
{"concept_id": "C1523588", "aliases": [], "types": ["T040"], "canonical_name": "forelimb morphogenesis", "definition": "The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. [GOC:go_curators]"}
{"concept_id": "C1523589", "aliases": [], "types": ["T040"], "canonical_name": "hindlimb morphogenesis", "definition": "The process in which the anatomical structures of the hindlimb are generated and organized. [GOC:go_curators]"}
{"concept_id": "C1523590", "aliases": [], "types": ["T040"], "canonical_name": "pectoral fin morphogenesis", "definition": "The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. [GOC:dgh]"}
{"concept_id": "C1523591", "aliases": [], "types": ["T040"], "canonical_name": "pelvic fin morphogenesis", "definition": "The process in which the anatomical structures of the pelvic fin are generated and organized. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. [GOC:dgh]"}
{"concept_id": "C1523592", "aliases": [], "types": ["T040"], "canonical_name": "arm morphogenesis"}
{"concept_id": "C1523593", "aliases": ["median fin morphogenesis", "unpaired fin morphogenesis"], "types": ["T040"], "canonical_name": "medial fin morphogenesis", "definition": "The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. [GOC:dgh]"}
{"concept_id": "C1523594", "aliases": [], "types": ["T040"], "canonical_name": "dorsal fin morphogenesis", "definition": "The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. [GOC:dgh]"}
{"concept_id": "C1523595", "aliases": [], "types": ["T040"], "canonical_name": "caudal fin morphogenesis", "definition": "The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion. [GOC:dgh]"}
{"concept_id": "C1523596", "aliases": [], "types": ["T040"], "canonical_name": "anal fin morphogenesis", "definition": "The process in which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. [GOC:dgh]"}
{"concept_id": "C1523597", "aliases": [], "types": ["T042"], "canonical_name": "tube fusion", "definition": "The joining of specific branches of a tubular system to form a continuous network. [GOC:bf]"}
{"concept_id": "C1523598", "aliases": ["tracheal branch fusion"], "types": ["T042"], "canonical_name": "branch fusion, open tracheal system", "definition": "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint. [GOC:mtg_sensu, PMID:14570584]"}
{"concept_id": "C1523599", "aliases": [], "types": ["T040"], "canonical_name": "lumen formation in an anatomical structure"}
{"concept_id": "C1523600", "aliases": ["tracheal lumen formation"], "types": ["T042"], "canonical_name": "lumen formation, open tracheal system", "definition": "Creation of the central hole of a tube in an open tracheal system through which gases flow. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1523601", "aliases": [], "types": ["T040"], "canonical_name": "regulation of tube size", "definition": "Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes. [PMID:10887083]"}
{"concept_id": "C1523602", "aliases": ["regulation of tracheal tube size"], "types": ["T042"], "canonical_name": "regulation of tube size, open tracheal system", "definition": "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape. [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]"}
{"concept_id": "C1523603", "aliases": ["regulation of tracheal tube architecture"], "types": ["T042"], "canonical_name": "regulation of tube architecture, open tracheal system", "definition": "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network. [GOC:mtg_sensu, PMID:14570584]"}
{"concept_id": "C1523604", "aliases": ["tracheal epithelial cell type specification"], "types": ["T043"], "canonical_name": "epithelial cell type specification, open tracheal system", "definition": "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions. [GOC:mtg_sensu, PMID:10684581, PMID:11063940]"}
{"concept_id": "C1523605", "aliases": ["terminal cell fate specification"], "types": ["T043"], "canonical_name": "terminal cell fate specification, open tracheal system", "definition": "The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange. [GOC:mtg_sensu, PMID:10684581, PMID:11063940]"}
{"concept_id": "C1523606", "aliases": ["downregulation of terminal cell fate specification", "down-regulation of terminal cell fate specification", "down regulation of terminal cell fate specification", "negative regulation of terminal cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of terminal cell fate specification, open tracheal system", "definition": "Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates. [GOC:mtg_sensu, PMID:10684581]"}
{"concept_id": "C1523607", "aliases": [], "types": ["T043"], "canonical_name": "fusion cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion. [PMID:11063940]"}
{"concept_id": "C1523608", "aliases": ["downregulation of fusion cell fate specification", "down regulation of fusion cell fate specification", "down-regulation of fusion cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of fusion cell fate specification", "definition": "Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates. [PMID:10684581]"}
{"concept_id": "C1523609", "aliases": ["tracheal tube expansion"], "types": ["T042"], "canonical_name": "tracheal tube dilation"}
{"concept_id": "C1523610", "aliases": ["regulation of tracheal tube length"], "types": ["T042"], "canonical_name": "regulation of tube length, open tracheal system", "definition": "Ensuring that a tube in an open tracheal system is of the correct length. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1523611", "aliases": ["maintenance of tracheal epithelial integrity"], "types": ["T042"], "canonical_name": "maintenance of epithelial integrity, open tracheal system", "definition": "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process. [GOC:mtg_sensu, PMID:10694415, PMID:14681183]"}
{"concept_id": "C1523612", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc lineage restriction", "definition": "Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment. [GOC:bf, PMID:10625531, PMID:9374402]"}
{"concept_id": "C1523613", "aliases": ["embryonic hematopoiesis", "embryonic haematopoiesis", "embryonic haemopoiesis"], "types": ["T042"], "canonical_name": "embryonic hemopoiesis", "definition": "The stages of blood cell formation that take place within the embryo. [GOC:bf]"}
{"concept_id": "C1523614", "aliases": ["embryonic hemocyte cell differentiation", "embryonic arthropod blood cell differentiation"], "types": ["T043"], "canonical_name": "embryonic hemocyte differentiation", "definition": "The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. [GOC:bf, GOC:mtg_sensu, PMID:14602069]"}
{"concept_id": "C1523615", "aliases": ["embryonic plasmatocyte cell differentiation"], "types": ["T043"], "canonical_name": "embryonic plasmatocyte differentiation", "definition": "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte. [GOC:bf, PMID:11921077, PMID:8174791]"}
{"concept_id": "C1523616", "aliases": [], "types": ["T043"], "canonical_name": "embryonic crystal cell differentiation", "definition": "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]"}
{"concept_id": "C1523617", "aliases": ["post-embryonic haemopoiesis"], "types": ["T040"], "canonical_name": "post-embryonic hemopoiesis", "definition": "The stages of blood cell formation that take place after completion of embryonic development. [GOC:bf]"}
{"concept_id": "C1523619", "aliases": ["larval lymph gland arthropod blood cell differentiation"], "types": ["T042"], "canonical_name": "larval lymph gland hemocyte differentiation", "definition": "The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu, PMID:14602069]"}
{"concept_id": "C1523620", "aliases": ["lymph gland plasmatocyte cell differentiation"], "types": ["T043"], "canonical_name": "lymph gland plasmatocyte differentiation", "definition": "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte. [GOC:bf, PMID:11921077, PMID:8174791]"}
{"concept_id": "C1523621", "aliases": [], "types": ["T043"], "canonical_name": "lymph gland crystal cell differentiation", "definition": "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]"}
{"concept_id": "C1523622", "aliases": ["lamellocyte cell differentiation"], "types": ["T040"], "canonical_name": "lamellocyte differentiation", "definition": "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. [GOC:bf, PMID:14734104]"}
{"concept_id": "C1523623", "aliases": ["arthropod blood cell proliferation"], "types": ["T043"], "canonical_name": "hemocyte proliferation", "definition": "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1523624", "aliases": [], "types": ["T044"], "canonical_name": "histone kinase activity", "definition": "Catalysis of the transfer of a phosphate group to a histone. [GOC:bf]"}
{"concept_id": "C1523625", "aliases": ["histone-serine kinase activity"], "types": ["T044"], "canonical_name": "histone serine kinase activity", "definition": "Catalysis of the transfer of a phosphate group to a serine residue of a histone. [GOC:bf]"}
{"concept_id": "C1523626", "aliases": ["histone serine kinase activity (H3-S10 specific)", "histone-serine kinase activity (H3-S10 specific)", "histone kinase activity (H3-S3 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H3-S10 specific)", "definition": "Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3. [GOC:bf, PMID:15041176]"}
{"concept_id": "C1523627", "aliases": ["larval foraging behaviour"], "types": ["T055"], "canonical_name": "larval foraging behavior", "definition": "The movement of a larva through a feeding substrate whilst feeding on food. [PMID:12848927]"}
{"concept_id": "C1523628", "aliases": ["turning behaviour"], "types": ["T055"], "canonical_name": "turning behavior", "definition": "Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source. [PMID:10880478]"}
{"concept_id": "C1523629", "aliases": ["larval turning behaviour"], "types": ["T055"], "canonical_name": "larval turning behavior", "definition": "Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source. [PMID:10880478]"}
{"concept_id": "C1523630", "aliases": ["larval wandering behaviour"], "types": ["T055"], "canonical_name": "larval wandering behavior", "definition": "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction. [PMID:12848927, PMID:12956960]"}
{"concept_id": "C1523631", "aliases": ["larval burrowing behaviour"], "types": ["T055"], "canonical_name": "larval burrowing behavior", "definition": "Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation. [PMID:12848927, PMID:12848939]"}
{"concept_id": "C1523634", "aliases": ["histone-threonine kinase activity"], "types": ["T044"], "canonical_name": "histone threonine kinase activity", "definition": "Catalysis of the transfer of a phosphate group to a threonine residue of a histone. [GOC:bf]"}
{"concept_id": "C1523635", "aliases": [], "types": ["T043"], "canonical_name": "preblastoderm mitotic cell cycle", "definition": "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. [ISBN:0879694238]"}
{"concept_id": "C1523636", "aliases": [], "types": ["T043"], "canonical_name": "syncytial blastoderm mitotic cell cycle", "definition": "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively. [ISBN:0879694238]"}
{"concept_id": "C1523637", "aliases": ["hatching behaviour"], "types": ["T055"], "canonical_name": "hatching behavior", "definition": "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell. [GOC:pr, PMID:10436051]"}
{"concept_id": "C1523638", "aliases": ["retinoblastoma-E2F complex location", "Rb-E2F complex location", "retinoblastoma-E2F complex"], "types": ["T026"], "canonical_name": "Rb-E2F complex", "definition": "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression. [PMID:14616073]"}
{"concept_id": "C1523639", "aliases": [], "types": ["T040"], "canonical_name": "syncytial nuclear migration", "definition": "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. [GOC:bf, ISBN:0879694238, PMID:8314839]"}
{"concept_id": "C1523640", "aliases": ["nucleus distribution along anterior-posterior axis", "nuclear distribution along anterior-posterior axis"], "types": ["T040"], "canonical_name": "nuclear axial expansion", "definition": "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex. [PMID:8314839]"}
{"concept_id": "C1523641", "aliases": [], "types": ["T040"], "canonical_name": "nuclear cortical migration", "definition": "The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo. [PMID:8314839]"}
{"concept_id": "C1523642", "aliases": ["CNS metamorphosis", "central nervous system metamorphosis"], "types": ["T042"], "canonical_name": "larval central nervous system remodeling", "definition": "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster. [GOC:sensu, PMID:9647692]"}
{"concept_id": "C1523644", "aliases": ["gene silencing by microRNA", "microRNA-mediated gene silencing", "gene silencing by miRNA"], "types": ["T045"], "canonical_name": "miRNA-mediated gene silencing", "definition": "A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. [GOC:aruk, GOC:bc, GOC:rl, PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154, PMID:23985560, PMID:28379604]"}
{"concept_id": "C1523646", "aliases": ["small interfering RNA binding"], "types": ["T045"], "canonical_name": "siRNA binding", "definition": "Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. [PMID:15066275, PMID:15066283]"}
{"concept_id": "C1523647", "aliases": ["microRNA binding"], "types": ["T045"], "canonical_name": "miRNA binding", "definition": "Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. [PMID:15066283]"}
{"concept_id": "C1523648", "aliases": [], "types": ["T055"], "canonical_name": "salt aversion", "definition": "The specific avoidance actions or reactions of an organism in response to the perception of salt. [GOC:bf]"}
{"concept_id": "C1523649", "aliases": [], "types": ["T042"], "canonical_name": "leg disc anterior/posterior pattern formation", "definition": "The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc. [GOC:bf]"}
{"concept_id": "C1523650", "aliases": [], "types": ["T042"], "canonical_name": "leg disc anterior/posterior lineage restriction", "definition": "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment. [GOC:bf]"}
{"concept_id": "C1523651", "aliases": [], "types": ["T042"], "canonical_name": "tracheal sac formation"}
{"concept_id": "C1523652", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lamellocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. [PMID:14734104]"}
{"concept_id": "C1523653", "aliases": ["down-regulation of lamellocyte differentiation", "downregulation of lamellocyte differentiation", "down regulation of lamellocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of lamellocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. [PMID:14734104]"}
{"concept_id": "C1523654", "aliases": ["up regulation of lamellocyte differentiation", "up-regulation of lamellocyte differentiation", "upregulation of lamellocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of lamellocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. [PMID:14734104]"}
{"concept_id": "C1523655", "aliases": ["regulation of arthropod blood cell proliferation"], "types": ["T043"], "canonical_name": "regulation of hemocyte proliferation", "definition": "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1523656", "aliases": ["downregulation of hemocyte proliferation", "negative regulation of arthropod blood cell proliferation", "down regulation of hemocyte proliferation", "down-regulation of hemocyte proliferation"], "types": ["T043"], "canonical_name": "negative regulation of hemocyte proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1523657", "aliases": ["up-regulation of hemocyte proliferation", "upregulation of hemocyte proliferation", "up regulation of hemocyte proliferation", "positive regulation of arthropod blood cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of hemocyte proliferation", "definition": "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1523658", "aliases": [], "types": ["T039"], "canonical_name": "pupal development", "definition": "The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1523659", "aliases": [], "types": ["T039"], "canonical_name": "prepupal development", "definition": "The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation. [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm]"}
{"concept_id": "C1523660", "aliases": [], "types": ["T038"], "canonical_name": "spermathecum morphogenesis", "definition": "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk. [PMID:12679097]"}
{"concept_id": "C1523661", "aliases": [], "types": ["T040"], "canonical_name": "cell competition in a multicellular organism", "definition": "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells. [GOC:bf, PMID:1116643, PMID:15066286]"}
{"concept_id": "C1523662", "aliases": ["development of structures derived from the clypeo-labral disc"], "types": ["T042"], "canonical_name": "clypeo-labral disc development", "definition": "The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1523663", "aliases": [], "types": ["T042"], "canonical_name": "eye-antennal disc development", "definition": "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1523664", "aliases": [], "types": ["T042"], "canonical_name": "genital disc development", "definition": "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia. [GOC:bf, ISBN:0879694238, PMID:11494318]"}
{"concept_id": "C1523665", "aliases": [], "types": ["T042"], "canonical_name": "haltere disc development", "definition": "Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1523666", "aliases": [], "types": ["T042"], "canonical_name": "labial disc development", "definition": "Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1523667", "aliases": [], "types": ["T042"], "canonical_name": "leg disc development", "definition": "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1523668", "aliases": [], "types": ["T042"], "canonical_name": "prothoracic disc development", "definition": "Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1523669", "aliases": [], "types": ["T042"], "canonical_name": "wing disc development", "definition": "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C1523670", "aliases": [], "types": ["T042"], "canonical_name": "genital disc pattern formation", "definition": "The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc. [GOC:bf]"}
{"concept_id": "C1523671", "aliases": [], "types": ["T042"], "canonical_name": "wing disc pattern formation", "definition": "The process giving rise to the pattern of cell differentiation in the wing imaginal disc. [GOC:bf]"}
{"concept_id": "C1523672", "aliases": [], "types": ["T042"], "canonical_name": "leg disc pattern formation", "definition": "The process that gives rise to the patterns of cell differentiation in the leg imaginal disc. [GOC:bf]"}
{"concept_id": "C1523673", "aliases": [], "types": ["T042"], "canonical_name": "genital disc anterior/posterior pattern formation", "definition": "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium). [PMID:11494318]"}
{"concept_id": "C1523674", "aliases": [], "types": ["T042"], "canonical_name": "determination of genital disc primordium", "definition": "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two. [GOC:bf, PMID:11494318]"}
{"concept_id": "C1523675", "aliases": [], "types": ["T044"], "canonical_name": "glutamate-cysteine ligase catalytic subunit binding", "definition": "Binding to the catalytic subunit of glutamate-cysteine ligase. [PMID:12954617]"}
{"concept_id": "C1523676", "aliases": [], "types": ["T044"], "canonical_name": "regulation of glutamate-cysteine ligase activity", "definition": "Any process that modulates the activity of glutamate-cysteine ligase. [GOC:bf]"}
{"concept_id": "C1523677", "aliases": ["down-regulation of glutamate-cysteine ligase activity", "down regulation of glutamate-cysteine ligase activity", "downregulation of glutamate-cysteine ligase activity"], "types": ["T044"], "canonical_name": "negative regulation of glutamate-cysteine ligase activity", "definition": "Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase. [GOC:bf]"}
{"concept_id": "C1523678", "aliases": ["up regulation of glutamate-cysteine ligase activity", "upregulation of glutamate-cysteine ligase activity", "up-regulation of glutamate-cysteine ligase activity"], "types": ["T044"], "canonical_name": "positive regulation of glutamate-cysteine ligase activity", "definition": "Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate. [PMID:12954617]"}
{"concept_id": "C1523679", "aliases": ["membrane nanotube"], "types": ["T026"], "canonical_name": "cytoneme", "definition": "A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um. [PMID:10367889, PMID:10675901]"}
{"concept_id": "C1523680", "aliases": [], "types": ["T043"], "canonical_name": "cytoneme biogenesis"}
{"concept_id": "C1523681", "aliases": [], "types": ["T043"], "canonical_name": "germ cell attraction", "definition": "The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target. [PMID:12885551]"}
{"concept_id": "C1523682", "aliases": [], "types": ["T043"], "canonical_name": "germ cell repulsion", "definition": "The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue. [PMID:12885551]"}
{"concept_id": "C1523683", "aliases": ["programmed cell death, ectopic germ cells", "programmed cell death of ectopic germ cells"], "types": ["T043"], "canonical_name": "ectopic germ cell programmed cell death", "definition": "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. [PMID:12814944]"}
{"concept_id": "C1523684", "aliases": ["ionotropic glutamate receptor signalling pathway"], "types": ["T044"], "canonical_name": "ionotropic glutamate receptor signaling pathway", "definition": "The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:0198506732]"}
{"concept_id": "C1523685", "aliases": [], "types": ["T044"], "canonical_name": "proctolin receptor activity", "definition": "Combining with the neuropeptide proctolin, to initiate a change in cell activity. [GOC:bf]"}
{"concept_id": "C1523686", "aliases": [], "types": ["T044"], "canonical_name": "corazonin receptor activity", "definition": "Combining with the neuropeptide corazonin to initiate a change in cell activity. [GOC:bf]"}
{"concept_id": "C1523687", "aliases": ["vitamin A biosynthesis", "vitamin A anabolism", "vitamin A biosynthetic process", "vitamin A synthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids. [PMID:11158606]", "canonical_name": "vitamin A formation"}
{"concept_id": "C1523688", "aliases": [], "types": ["T040"], "canonical_name": "tube morphogenesis", "definition": "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. [GOC:bf, PMID:14624839]"}
{"concept_id": "C1523689", "aliases": [], "types": ["T044"], "canonical_name": "dopamine binding", "definition": "Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. [ISBN:0198506732]"}
{"concept_id": "C1523690", "aliases": [], "types": ["T044"], "canonical_name": "protein-arginine omega-N monomethyltransferase activity", "definition": "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine. [EC:2.1.1.321, PMID:14705965, RESID:AA0069]"}
{"concept_id": "C1523691", "aliases": [], "types": ["T044"], "canonical_name": "protein-arginine omega-N asymmetric methyltransferase activity", "definition": "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. [PMID:14705965, RESID:AA0068, RESID:AA0069, RHEA:48096]"}
{"concept_id": "C1523692", "aliases": [], "types": ["T044"], "canonical_name": "protein-arginine omega-N symmetric methyltransferase activity", "definition": "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues. [EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069]"}
{"concept_id": "C1523693", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine C-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. [GOC:bf]"}
{"concept_id": "C1523694", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine C-methylation", "definition": "The addition of a methyl group onto a carbon atom of an arginine residue in a protein. [GOC:bf]"}
{"concept_id": "C1523695", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine N-methylation", "definition": "The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein. [GOC:bf]"}
{"concept_id": "C1523696", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine omega-N-methylation", "definition": "The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein. [PMID:14705965, RESID:AA0067, RESID:AA0068, RESID:AA0069]"}
{"concept_id": "C1523697", "aliases": ["alpha-1,4-GalNAc transferase activity"], "types": ["T044"], "canonical_name": "alpha-1,4-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage. [PMID:15130086]"}
{"concept_id": "C1523698", "aliases": ["glutamatergic synaptic transmission"], "types": ["T043"], "canonical_name": "synaptic transmission, glutamatergic", "definition": "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos]"}
{"concept_id": "C1523699", "aliases": [], "types": ["T044"], "canonical_name": "UDP-galactosyltransferase activity", "definition": "Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. [PMID:19858195]"}
{"concept_id": "C1523701", "aliases": [], "types": ["T044"], "canonical_name": "UDP-xylosyltransferase activity", "definition": "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. [PMID:30127001]"}
{"concept_id": "C1523703", "aliases": [], "types": ["T044"], "canonical_name": "glutamate receptor binding", "definition": "Binding to a glutamate receptor. [GOC:bf]"}
{"concept_id": "C1523704", "aliases": [], "types": ["T044"], "canonical_name": "ionotropic glutamate receptor binding", "definition": "Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. [GOC:bf, ISBN:0198506732]"}
{"concept_id": "C1523708", "aliases": [], "types": ["T044"], "canonical_name": "glucocorticoid receptor binding"}
{"concept_id": "C1523709", "aliases": [], "types": ["T042"], "canonical_name": "internal genitalia morphogenesis", "definition": "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. [http://www.ndif.org/Terms/genitalia.html]"}
{"concept_id": "C1523710", "aliases": [], "types": ["T042"], "canonical_name": "external genitalia morphogenesis", "definition": "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. [http://www.ndif.org/Terms/genitalia.html]"}
{"concept_id": "C1523711", "aliases": [], "types": ["T042"], "canonical_name": "gonad morphogenesis", "definition": "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. [ISBN:0198612001]"}
{"concept_id": "C1523712", "aliases": [], "types": ["T042"], "canonical_name": "genital disc sexually dimorphic development", "definition": "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed. [PMID:11290302, PMID:11494318, PMID:11702781]"}
{"concept_id": "C1523713", "aliases": [], "types": ["T040"], "canonical_name": "organ growth", "definition": "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. [GOC:bf, ISBN:0471245208, ISBN:0721662544]"}
{"concept_id": "C1523714", "aliases": [], "types": ["T040"], "canonical_name": "meristem growth", "definition": "The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation. [GOC:bf, ISBN:0198547684]"}
{"concept_id": "C1523715", "aliases": ["NuA4 histone acetyltransferase complex location", "TIP60 histone acetylase complex", "TIP60 histone acetyltransferase complex", "TIP60 histone acetyltransferase complex location", "TIP60 histone acetylase complex location"], "types": ["T026"], "canonical_name": "NuA4 histone acetyltransferase complex", "definition": "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). [GOC:ecd, PMID:10966108, PMID:14966270]"}
{"concept_id": "C1523716", "aliases": ["protein amino acid mannosylation"], "types": ["T044"], "canonical_name": "protein mannosylation", "definition": "The addition of a mannose residue to a protein acceptor molecule. [GOC:bf, GOC:pr]"}
{"concept_id": "C1523717", "aliases": ["protein amino acid O-linked mannosylation"], "types": ["T044"], "canonical_name": "protein O-linked mannosylation", "definition": "The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. [GOC:bf, PMID:9878797]"}
{"concept_id": "C1523718", "aliases": [], "types": ["T038"], "canonical_name": "endocrine system development", "definition": "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. [GOC:bf, Wikipedia:Development_of_the_endocrine_system]"}
{"concept_id": "C1523719", "aliases": [], "types": ["T038"], "canonical_name": "ring gland development", "definition": "Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones. [GOC:bf, PMID:11223816, PMID:9584098]"}
{"concept_id": "C1523720", "aliases": [], "types": ["T038"], "canonical_name": "exocrine system development", "definition": "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. [GOC:bf, Wikipedia:Exocrine_gland]"}
{"concept_id": "C1523721", "aliases": [], "types": ["T044"], "canonical_name": "phthalate binding", "definition": "Binding to a phthalate, any ester or salt of phthalic acid. [http://umbbd.ahc.umn.edu/pth/pth_map.html]"}
{"concept_id": "C1523722", "aliases": ["DPP binding"], "types": ["T044"], "canonical_name": "diphenyl phthalate binding", "definition": "Binding to diphenyl phthalate, C(20)H(14)O(4). [http://www.sigmaaldrich.com]"}
{"concept_id": "C1523723", "aliases": ["phthalic acid dibutyl ester binding", "DBP binding"], "types": ["T044"], "canonical_name": "dibutyl phthalate binding", "definition": "Binding to dibutyl phthalate, C(16)H(22)O(4). [http://www.sigmaaldrich.com]"}
{"concept_id": "C1523724", "aliases": [], "types": ["T044"], "canonical_name": "ethanol binding", "definition": "Binding to ethanol, CH(3)-CH(2)-OH. [ISBN:0198506732]"}
{"concept_id": "C1523725", "aliases": ["spiracle morphogenesis"], "types": ["T042"], "canonical_name": "spiracle morphogenesis, open tracheal system", "definition": "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk. [GOC:mtg_sensu, PMID:10491268]"}
{"concept_id": "C1523726", "aliases": [], "types": ["T043"], "canonical_name": "miRNA-mediated gene silencing, negative regulation of translation"}
{"concept_id": "C1523727", "aliases": ["gene silencing by miRNA, mRNA cleavage", "mRNA cleavage involved in gene silencing by miRNA", "miRNA-mediated gene silencing, mRNA cleavage", "mRNA destabilization-mediated gene silencing by miRNA", "mRNA cleavage involved in gene silencing by microRNA"], "types": ["T045"], "canonical_name": "miRNA-mediated gene silencing by mRNA destabilization", "definition": "An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism. [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554]"}
{"concept_id": "C1523730", "aliases": [], "types": ["T042"], "canonical_name": "central nervous system segmentation", "definition": "Division of the central nervous system into a series of semi-repetitive parts or segments. [GOC:bf]"}
{"concept_id": "C1523731", "aliases": [], "types": ["T042"], "canonical_name": "brain segmentation", "definition": "Division of the brain into a series of semi-repetitive parts or segments. [GOC:bf]"}
{"concept_id": "C1523732", "aliases": [], "types": ["T040"], "canonical_name": "appendage segmentation", "definition": "Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented. [PMID:10357895]"}
{"concept_id": "C1523734", "aliases": [], "types": ["T040"], "canonical_name": "head segmentation", "definition": "Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial). [PMID:10477305, PMID:7915837]"}
{"concept_id": "C1523735", "aliases": [], "types": ["T040"], "canonical_name": "procephalic segmentation"}
{"concept_id": "C1523736", "aliases": [], "types": ["T040"], "canonical_name": "posterior head segmentation", "definition": "Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains. [PMID:15382136]"}
{"concept_id": "C1523737", "aliases": [], "types": ["T040"], "canonical_name": "trunk segmentation", "definition": "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. [PMID:1360402]"}
{"concept_id": "C1523738", "aliases": [], "types": ["T040"], "canonical_name": "specification of segmental identity, intercalary segment", "definition": "The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [ISBN:0878932437, PMID:10477305]"}
{"concept_id": "C1523739", "aliases": [], "types": ["T040"], "canonical_name": "specification of segmental identity, trunk", "definition": "The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [PMID:1360402]"}
{"concept_id": "C1523740", "aliases": [], "types": ["T044"], "canonical_name": "chitin-based larval cuticle pattern formation", "definition": "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1523741", "aliases": [], "types": ["T042"], "canonical_name": "determination of wing disc primordium", "definition": "Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc. [ISBN:0879694238]"}
{"concept_id": "C1523742", "aliases": [], "types": ["T039"], "canonical_name": "tube development", "definition": "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. [PMID:12526790]"}
{"concept_id": "C1523743", "aliases": [], "types": ["T040"], "canonical_name": "regulation of tube diameter", "definition": "Any process that modulates the diameter of a tube. [GOC:bf]"}
{"concept_id": "C1523744", "aliases": [], "types": ["T042"], "canonical_name": "regulation of Malpighian tubule diameter", "definition": "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells. [PMID:9286684]"}
{"concept_id": "C1523745", "aliases": [], "types": ["T042"], "canonical_name": "regulation of Malpighian tubule size", "definition": "Ensuring that a Malpighian tubule is the correct length and diameter. [GOC:bf]"}
{"concept_id": "C1523746", "aliases": ["IP5 2-kinase activity", "inositol-pentakisphosphate 2-kinase activity", "Ins(1,3,4,5,6)P5 2-kinase activity", "Gsl1p", "Ipk1p", "ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity", "inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity", "inositol polyphosphate kinase activity"], "types": ["T044"], "canonical_name": "inositol pentakisphosphate 2-kinase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+). [RHEA:20313]"}
{"concept_id": "C1523748", "aliases": ["Hedgehog signaling complex location", "Hedgehog signalling complex location", "Hedgehog signalling complex", "Hedgehog signaling complex"], "types": ["T026"], "definition": "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila). [PMID:10825151, PMID:15057936]", "canonical_name": "HSC"}
{"concept_id": "C1523749", "aliases": [], "types": ["T044"], "canonical_name": "ecdysteroid 25-hydroxylase activity", "definition": "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods. [ISBN:0198506732, PMID:15350618]"}
{"concept_id": "C1523750", "aliases": [], "types": ["T043"], "canonical_name": "compound eye photoreceptor development", "definition": "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure. [GOC:bf]"}
{"concept_id": "C1523751", "aliases": ["establishment of ommatidial polarity"], "types": ["T043"], "canonical_name": "establishment of ommatidial planar polarity", "definition": "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part. [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]"}
{"concept_id": "C1523752", "aliases": ["arthropod blood cell differentiation"], "types": ["T042"], "canonical_name": "hemocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723]"}
{"concept_id": "C1523753", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell fate specification", "definition": "Any process that mediates the adoption of a specific fate by a cell. [GOC:go_curators]"}
{"concept_id": "C1523754", "aliases": ["up-regulation of cell fate specification", "upregulation of cell fate specification", "up regulation of cell fate specification"], "types": ["T043"], "canonical_name": "positive regulation of cell fate specification", "definition": "Any process that activates or enables a cell to adopt a specific fate. [GOC:go_curators]"}
{"concept_id": "C1523756", "aliases": ["auditory hair cell fate specification"], "types": ["T043"], "canonical_name": "auditory receptor cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:go_curators]"}
{"concept_id": "C1523757", "aliases": ["auditory hair cell fate determination"], "types": ["T043"], "canonical_name": "auditory receptor cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:go_curators]"}
{"concept_id": "C1523758", "aliases": ["regulation of auditory hair cell fate specification"], "types": ["T043"], "canonical_name": "regulation of inner ear auditory receptor cell fate specification", "definition": "Any process that mediates the specification of a cell into an auditory hair cell. [GOC:go_curators]"}
{"concept_id": "C1523765", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardioblast cell fate specification", "definition": "Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:go_curators]"}
{"concept_id": "C1523766", "aliases": [], "types": ["T040"], "canonical_name": "embryonic digit morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. [GOC:bf, GOC:jl, UBERON:0002544]"}
{"concept_id": "C1523768", "aliases": ["dihydrosirohydrochlorin dehydrogenase activity", "1,3-dimethyluroporphyrinogen III dehydrogenase activity", "precorrin-2 oxidase activity", "precorrin-2:NAD+ oxidoreductase activity", "precorrin-2 dehydrogenase activity", "SirC", "CysG"], "types": ["T044"], "definition": "Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin. [EC:1.3.1.76, RHEA:15613]", "canonical_name": "Met8p"}
{"concept_id": "C1523769", "aliases": ["regulation of I-kappaB kinase/NF-kappaB cascade"], "types": ["T044"], "canonical_name": "regulation of I-kappaB kinase/NF-kappaB signaling", "definition": "Any process that modulates I-kappaB kinase/NF-kappaB signaling. [GOC:jl, PMID:12773372]"}
{"concept_id": "C1523770", "aliases": ["up-regulation of I-kappaB kinase/NF-kappaB cascade", "positive regulation of I-kappaB kinase/NF-kappaB cascade", "upregulation of I-kappaB kinase/NF-kappaB cascade", "up regulation of I-kappaB kinase/NF-kappaB cascade"], "types": ["T044"], "canonical_name": "positive regulation of I-kappaB kinase/NF-kappaB signaling", "definition": "Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. [GOC:jl]"}
{"concept_id": "C1523771", "aliases": ["down regulation of I-kappaB kinase/NF-kappaB cascade", "down-regulation of I-kappaB kinase/NF-kappaB cascade", "downregulation of I-kappaB kinase/NF-kappaB cascade", "negative regulation of I-kappaB kinase/NF-kappaB cascade"], "types": ["T044"], "canonical_name": "negative regulation of I-kappaB kinase/NF-kappaB signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. [GOC:jl]"}
{"concept_id": "C1523772", "aliases": ["HER3 receptor binding"], "types": ["T044"], "canonical_name": "ErbB-3 class receptor binding", "definition": "Binding to the protein-tyrosine kinase receptor ErbB-3/HER3. [GOC:jl]"}
{"concept_id": "C1523773", "aliases": ["regulation of PI4K activity"], "types": ["T044"], "canonical_name": "regulation of 1-phosphatidylinositol 4-kinase activity", "definition": "Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase. [GOC:jl]"}
{"concept_id": "C1523774", "aliases": ["negative regulation of PI4K activity", "down regulation of 1-phosphatidylinositol 4-kinase activity", "downregulation of 1-phosphatidylinositol 4-kinase activity", "down-regulation of 1-phosphatidylinositol 4-kinase activity"], "types": ["T044"], "canonical_name": "negative regulation of 1-phosphatidylinositol 4-kinase activity", "definition": "Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase. [GOC:jl]"}
{"concept_id": "C1523775", "aliases": ["up-regulation of 1-phosphatidylinositol 4-kinase activity", "positive regulation of PI4K activity", "up regulation of 1-phosphatidylinositol 4-kinase activity", "upregulation of 1-phosphatidylinositol 4-kinase activity"], "types": ["T044"], "canonical_name": "positive regulation of 1-phosphatidylinositol 4-kinase activity", "definition": "Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase. [GOC:jl]"}
{"concept_id": "C1523776", "aliases": [], "types": ["T040"], "canonical_name": "surfactant homeostasis", "definition": "Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli. [PMID:9751757]"}
{"concept_id": "C1523777", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin binding", "definition": "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. [GOC:ecd]"}
{"concept_id": "C1523778", "aliases": ["reduced nicotinamide adenine dinucleotide transport", "oxidized NAD transport", "NADH transport", "nicotinamide adenine dinucleotide transport", "oxidized nicotinamide adenine dinucleotide transport", "NAD (reduced) transport", "NAD (oxidized) transport", "reduced NAD transport"], "types": ["T043"], "canonical_name": "NAD transport", "definition": "The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH. [GOC:jl]"}
{"concept_id": "C1523779", "aliases": [], "types": ["T042"], "canonical_name": "hindgut contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. [GOC:jl, GOC:mtg_muscle, UBERON:0001046]"}
{"concept_id": "C1523780", "aliases": [], "types": ["T042"], "canonical_name": "regulation of hindgut contraction", "definition": "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. [GOC:jl, UBERON:0001046]"}
{"concept_id": "C1523781", "aliases": ["PRPP pyrophosphatase activity"], "types": ["T044"], "canonical_name": "5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity", "definition": "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+. [MetaCyc:RXN-10969, PMID:12370170]"}
{"concept_id": "C1523783", "aliases": ["Okazaki initiator RNA removal"], "types": ["T045"], "canonical_name": "DNA replication, removal of RNA primer", "definition": "Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease. [GOC:jl, PMID:12424238]"}
{"concept_id": "C1523784", "aliases": ["ATP-dependent 3' to 5' DNA helicase activity", "ATP-dependent 3'-5' DNA helicase activity", "3' to 5' DNA helicase activity"], "types": ["T045"], "canonical_name": "3'-5' DNA helicase activity", "definition": "Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. [GOC:jl]"}
{"concept_id": "C1523785", "aliases": ["ATP-dependent 5'-3' DNA helicase activity", "5' to 3' DNA helicase activity", "ATP-dependent 5' to 3' DNA helicase activity"], "types": ["T045"], "canonical_name": "5'-3' DNA helicase activity", "definition": "Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis. [GOC:jl]"}
{"concept_id": "C1523789", "aliases": ["establishment and maintenance of translational protein localization", "translational machinery localization", "regulation of translation by machinery localisation", "translational protein localization", "establishment and maintenance of translational machinery localization"], "types": ["T043"], "canonical_name": "regulation of translation by machinery localization", "definition": "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. [GOC:jl]"}
{"concept_id": "C1523790", "aliases": [], "types": ["T045"], "canonical_name": "sno(s)RNA processing", "definition": "Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea). [GOC:go_curators, GOC:krc, PMID:12773397]"}
{"concept_id": "C1523791", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA 3'-end cleavage"}
{"concept_id": "C1523792", "aliases": [], "types": ["T043"], "canonical_name": "spindle stabilization"}
{"concept_id": "C1523793", "aliases": [], "types": ["T043"], "canonical_name": "meiotic spindle stabilization"}
{"concept_id": "C1523794", "aliases": [], "types": ["T043"], "canonical_name": "mitotic spindle stabilization"}
{"concept_id": "C1523795", "aliases": ["stress fibre biosynthesis", "stress fibre formation"], "types": ["T043"], "canonical_name": "stress fiber assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. [GOC:go_curators, GOC:mah, PMID:16651381]"}
{"concept_id": "C1523796", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis during double-strand break repair via homologous recombination"}
{"concept_id": "C1523797", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis during double-strand break repair via single-strand annealing"}
{"concept_id": "C1523798", "aliases": [], "types": ["T046"], "canonical_name": "induction of bacterial agglutination", "definition": "Any process in which infecting bacteria are clumped together by a host organism. [GOC:jl]"}
{"concept_id": "C1523799", "aliases": ["photoentrainment of circadian clock"], "types": ["T040"], "canonical_name": "entrainment of circadian clock by photoperiod", "definition": "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). [GOC:jl]"}
{"concept_id": "C1523801", "aliases": ["down regulation of photosynthesis, light reaction", "downregulation of photosynthesis, light reaction", "down-regulation of photosynthesis, light reaction"], "types": ["T043"], "canonical_name": "negative regulation of photosynthesis, light reaction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis. [GOC:jl]"}
{"concept_id": "C1523803", "aliases": [], "types": ["T043"], "canonical_name": "response to cation stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment. [GOC:jl, PMID:14762213]"}
{"concept_id": "C1523804", "aliases": ["heterocyst biosynthesis", "heterocyst formation", "heterocyst cell differentiation"], "types": ["T043"], "canonical_name": "heterocyst differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen. [GOC:jl]"}
{"concept_id": "C1523805", "aliases": [], "types": ["T026"], "canonical_name": "acrosomal matrix", "definition": "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction. [GOC:jl, PMID:8949900, PMID:9139729]"}
{"concept_id": "C1523806", "aliases": [], "types": ["T026"], "canonical_name": "acrosomal lumen", "definition": "The volume enclosed within the acrosome membrane. [GOC:go_curators]"}
{"concept_id": "C1523807", "aliases": ["proteasomal ubiquitin-dependent protein breakdown", "proteasomal pathway", "proteasomal ubiquitin-dependent protein catabolism", "proteasomal ubiquitin-dependent protein degradation", "proteasomal ubiquitin-dependent protein catabolic process"], "types": ["T044"], "canonical_name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:go_curators]"}
{"concept_id": "C1523808", "aliases": ["ubiquitin-dependent protein catabolism via the MVB pathway", "ubiquitin-dependent protein breakdown via the multivesicular body pathway", "ubiquitin-dependent protein degradation via the multivesicular body pathway", "ubiquitin-dependent protein catabolic process via the MVB pathway"], "types": ["T044"], "canonical_name": "ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. [GOC:jl, PMID:11511343]"}
{"concept_id": "C1523809", "aliases": ["cell envelope organisation", "cell envelope organization and biogenesis"], "types": ["T043"], "canonical_name": "cell envelope organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present. [GOC:jl]"}
{"concept_id": "C1523810", "aliases": ["1-2nm peptidoglycan-based cell wall biogenesis"], "types": ["T043"], "canonical_name": "Gram-negative-bacterium-type cell wall biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. [GOC:jl, GOC:mtg_sensu, ISBN:0815108893]"}
{"concept_id": "C1523811", "aliases": [], "types": ["T043"], "canonical_name": "cell outer membrane biogenesis"}
{"concept_id": "C1523812", "aliases": [], "types": ["T044"], "canonical_name": "H4/H2 histone acetyltransferase activity"}
{"concept_id": "C1523813", "aliases": [], "types": ["T044"], "canonical_name": "atom binding"}
{"concept_id": "C1523814", "aliases": [], "types": ["T044"], "canonical_name": "anion binding", "definition": "Binding to an anion, a charged atom or group of atoms with a net negative charge. [GOC:jl]"}
{"concept_id": "C1523815", "aliases": [], "types": ["T044"], "canonical_name": "cation binding", "definition": "Binding to a cation, a charged atom or group of atoms with a net positive charge. [GOC:jl]"}
{"concept_id": "C1523816", "aliases": ["macromolecule metabolism", "biopolymer metabolic process", "organismal macromolecule metabolism"], "types": ["T044"], "canonical_name": "macromolecule metabolic process", "definition": "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:mah]"}
{"concept_id": "C1523817", "aliases": ["peptide degradation", "peptide catabolism", "peptide breakdown"], "types": ["T044"], "canonical_name": "peptide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:jl]"}
{"concept_id": "C1523819", "aliases": [], "types": ["T043"], "canonical_name": "nucleotide salvage", "definition": "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1523820", "aliases": [], "types": ["T043"], "canonical_name": "nucleoside salvage", "definition": "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. [GOC:jl]"}
{"concept_id": "C1523821", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase core enzyme binding", "definition": "Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. [GOC:jl, GOC:txnOH]"}
{"concept_id": "C1523822", "aliases": [], "types": ["T044"], "canonical_name": "amine binding", "definition": "Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group. [GOC:jl]"}
{"concept_id": "C1523823", "aliases": [], "types": ["T044"], "canonical_name": "organic acid binding", "definition": "Binding to an organic acid, any acidic compound containing carbon in covalent linkage. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1523824", "aliases": [], "types": ["T044"], "canonical_name": "alcohol binding", "definition": "Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1523825", "aliases": [], "types": ["T043"], "canonical_name": "rhythmic excitation", "definition": "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit. [GOC:go_curators, ISBN:0195088433]"}
{"concept_id": "C1523826", "aliases": [], "types": ["T043"], "canonical_name": "rhythmic inhibition", "definition": "Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit. [GOC:go_curators]"}
{"concept_id": "C1523827", "aliases": ["sequestering in vacuole", "sequestration in vacuole", "vacuolar retention", "vacuolar sequestration", "retention in vacuole", "vacuolar storage", "storage in vacuole"], "types": ["T043"], "canonical_name": "vacuolar sequestering", "definition": "The process of transporting a substance into, and confining within, a vacuole. [GOC:jl]"}
{"concept_id": "C1523828", "aliases": ["vacuolar sodium ion (Na+) storage", "vacuolar sodium ion (Na+) retention", "sodium ion (Na+) storage in vacuole", "sequestering of sodium ion (Na+) in vacuole", "vacuolar sequestering of sodium ion (Na+)", "vacuolar sequestration of sodium ion (Na+)", "sodium ion (Na+) retention in vacuole", "sequestration of sodium ion (Na+) in vacuole"], "types": ["T043"], "canonical_name": "vacuolar sequestering of sodium ion", "definition": "The process of transporting sodium ions into, and confining within, a vacuole. [GOC:jl]"}
{"concept_id": "C1523829", "aliases": ["VEGFR 1 binding", "VEGF receptor 1 binding", "Flt-1 binding"], "types": ["T044"], "canonical_name": "vascular endothelial growth factor receptor 1 binding", "definition": "Binding to a vascular endothelial growth factor receptor 1. [GOC:st]"}
{"concept_id": "C1523830", "aliases": ["VEGF receptor 2 binding", "VEGFR 2 binding", "kinase domain region binding", "Flk-1 binding"], "types": ["T044"], "canonical_name": "vascular endothelial growth factor receptor 2 binding", "definition": "Binding to a vascular endothelial growth factor receptor 2. [GOC:st]"}
{"concept_id": "C1523831", "aliases": ["VEGFR 3 binding", "fms-like-tyrosine kinase (Flt)-4 binding", "VEGF receptor 3 binding"], "types": ["T044"], "canonical_name": "vascular endothelial growth factor receptor 3 binding", "definition": "Binding to a vascular endothelial growth factor receptor 3. [GOC:st]"}
{"concept_id": "C1523832", "aliases": ["nuage", "polar granule"], "types": ["T026"], "definition": "A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. [GOC:dph, GOC:kmv, PMID:11262230]", "canonical_name": "P granule"}
{"concept_id": "C1523834", "aliases": [], "types": ["T026"], "canonical_name": "cell septum edging", "definition": "The cell wall material that surrounds the septum in fungal cells. [GOC:vw]"}
{"concept_id": "C1523835", "aliases": ["H4/H2A histone acetyltransferase complex location", "H4/H2A HAT complex location", "H4/H2A HAT complex"], "types": ["T026"], "canonical_name": "H4/H2A histone acetyltransferase complex", "definition": "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A. [GOC:mah, GOC:rb]"}
{"concept_id": "C1523836", "aliases": ["ATP-binding cassette (ABC) transporter complex location"], "types": ["T026"], "canonical_name": "ATP-binding cassette (ABC) transporter complex", "definition": "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]"}
{"concept_id": "C1523842", "aliases": ["dendritic shaft"], "types": ["T026"], "definition": "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. [GOC:nln]", "canonical_name": "trunk"}
{"concept_id": "C1523843", "aliases": [], "types": ["T044"], "canonical_name": "sulfate binding", "definition": "Binding to sulfate, SO4(2-), a negatively charged small molecule. [GOC:mlg]"}
{"concept_id": "C1523844", "aliases": ["response to amino acid stimulus"], "types": ["T040"], "canonical_name": "response to amino acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:ef, GOC:mlg]"}
{"concept_id": "C1523845", "aliases": [], "types": ["T040"], "canonical_name": "response to leucine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus. [GOC:mlg]"}
{"concept_id": "C1523846", "aliases": [], "types": ["T026"], "canonical_name": "lysosomal lumen", "definition": "The volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228]"}
{"concept_id": "C1523847", "aliases": ["fibril organisation"], "types": ["T043"], "canonical_name": "fibril organization"}
{"concept_id": "C1523848", "aliases": [], "types": ["T040"], "canonical_name": "response to external biotic stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. [GOC:go_curators]"}
{"concept_id": "C1523849", "aliases": [], "types": ["T044"], "canonical_name": "glycosphingolipid binding", "definition": "Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [GOC:jl]"}
{"concept_id": "C1523850", "aliases": [], "types": ["T044"], "canonical_name": "alkanesulfonate binding", "definition": "Binding to alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. [GOC:mlg]"}
{"concept_id": "C1523851", "aliases": ["ATP-dependent carbohydrate transmembrane transporter activity", "carbohydrate-transporting ATPase activity", "ATPase-coupled carbohydrate transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type carbohydrate transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane. [GOC:mlg]"}
{"concept_id": "C1523852", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate-exporting ATPase activity"}
{"concept_id": "C1523853", "aliases": [], "types": ["T043"], "canonical_name": "bacteriocin transport", "definition": "The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain. [GOC:mlg]"}
{"concept_id": "C1523854", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled bacteriocin transmembrane transporter activity"}
{"concept_id": "C1523855", "aliases": [], "types": ["T043"], "canonical_name": "daunorubicin transport", "definition": "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, GOC:mlg]"}
{"concept_id": "C1523857", "aliases": [], "types": ["T042"], "canonical_name": "myelin maintenance", "definition": "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. [GOC:dgh]"}
{"concept_id": "C1523858", "aliases": [], "types": ["T026"], "canonical_name": "compact myelin", "definition": "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. [GOC:dgh, NIF_Subcellular:sao1123256993]"}
{"concept_id": "C1523859", "aliases": [], "types": ["T026"], "canonical_name": "lateral loop", "definition": "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode. [GOC:dgh]"}
{"concept_id": "C1523862", "aliases": ["cytoplasmic Skp1/Cul1/F-box protein complex", "cytoplasmic SCF complex", "cytoplasmic Skp1/Cul1/F-box protein complex location", "cytoplasmic SCF complex location", "cytoplasmic SCF ubiquitin ligase complex location", "cytoplasmic cullin complex", "cytoplasmic cullin complex location"], "types": ["T026"], "canonical_name": "cytoplasmic SCF ubiquitin ligase complex", "definition": "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1523863", "aliases": ["nuclear SCF ubiquitin ligase complex location", "nuclear Skp1/Cul1/F-box protein complex", "nuclear Skp1/Cul1/F-box protein complex location", "nuclear SCF complex location", "nuclear SCF complex", "nuclear cullin complex", "nuclear cullin complex location"], "types": ["T026"], "canonical_name": "nuclear SCF ubiquitin ligase complex", "definition": "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1523864", "aliases": ["anion-transporting ATPase activity", "ATP-dependent anion transmembrane transporter activity", "ATPase-coupled anion transmembrane transporter activity", "anion transmembrane-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled inorganic anion transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in). [GOC:mlg]"}
{"concept_id": "C1523865", "aliases": ["membrane-enclosed organelle"], "types": ["T026"], "canonical_name": "membrane-bounded organelle", "definition": "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]"}
{"concept_id": "C1523866", "aliases": ["non-membrane-enclosed organelle"], "types": ["T026"], "canonical_name": "non-membrane-bounded organelle", "definition": "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. [GOC:go_curators]"}
{"concept_id": "C1523867", "aliases": [], "types": ["T026"], "canonical_name": "intracellular organelle", "definition": "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:go_curators]"}
{"concept_id": "C1523868", "aliases": [], "types": ["T026"], "canonical_name": "extracellular organelle", "definition": "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. [GOC:jl, PMID:9914479]"}
{"concept_id": "C1523869", "aliases": ["intracellular membrane-enclosed organelle"], "types": ["T026"], "canonical_name": "intracellular membrane-bounded organelle", "definition": "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]"}
{"concept_id": "C1523870", "aliases": ["intracellular non-membrane-enclosed organelle"], "types": ["T026"], "canonical_name": "intracellular non-membrane-bounded organelle", "definition": "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. [GOC:go_curators]"}
{"concept_id": "C1523871", "aliases": [], "types": ["T026"], "canonical_name": "organelle lumen", "definition": "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. [GOC:jl, GOC:mah]"}
{"concept_id": "C1523872", "aliases": ["protein complex"], "types": ["T026"], "canonical_name": "protein complex location"}
{"concept_id": "C1523873", "aliases": ["receptor complex location"], "types": ["T026"], "canonical_name": "receptor complex", "definition": "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]"}
{"concept_id": "C1523874", "aliases": [], "types": ["T044"], "canonical_name": "laminin binding", "definition": "Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells. [GOC:ecd]"}
{"concept_id": "C1523875", "aliases": ["laminin-111 binding"], "types": ["T044"], "canonical_name": "laminin-1 binding", "definition": "Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. [GOC:go_curators]"}
{"concept_id": "C1523876", "aliases": [], "types": ["T044"], "canonical_name": "laminin-2 binding"}
{"concept_id": "C1523877", "aliases": [], "types": ["T044"], "canonical_name": "laminin-4 binding"}
{"concept_id": "C1523878", "aliases": ["FA core complex location", "FA complex", "FA core complex", "Fanconi anaemia complex", "FA nuclear complex", "Fanconi anaemia nuclear complex location", "FA nuclear complex location", "FA complex location", "Fanconi anaemia complex location"], "types": ["T026"], "canonical_name": "Fanconi anaemia nuclear complex", "definition": "A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. [GOC:jl, PMID:12093742]"}
{"concept_id": "C1523879", "aliases": ["protein complex disassembly"], "types": ["T043"], "canonical_name": "protein-containing complex disassembly", "definition": "The disaggregation of a protein-containing macromolecular complex into its constituent components. [GOC:mah]"}
{"concept_id": "C1523880", "aliases": ["downregulation of protein complex disassembly", "down-regulation of protein complex disassembly", "negative regulation of protein complex disassembly", "down regulation of protein complex disassembly"], "types": ["T044"], "canonical_name": "negative regulation of protein-containing complex disassembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. [GOC:jl]"}
{"concept_id": "C1523881", "aliases": ["up-regulation of protein complex disassembly", "up regulation of protein complex disassembly", "upregulation of protein complex disassembly", "positive regulation of protein complex disassembly"], "types": ["T044"], "canonical_name": "positive regulation of protein-containing complex disassembly", "definition": "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. [GOC:jl]"}
{"concept_id": "C1523882", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein complex disassembly"}
{"concept_id": "C1523883", "aliases": [], "types": ["T026"], "canonical_name": "extraorganismal space", "definition": "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms. [GOC:jl]"}
{"concept_id": "C1523884", "aliases": [], "types": ["T026"], "canonical_name": "megasome", "definition": "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex. [PMID:11206117, PMID:1999020]"}
{"concept_id": "C1523885", "aliases": ["DNA damage response, telomere maintenance"], "types": ["T045"], "canonical_name": "telomere maintenance in response to DNA damage", "definition": "Any process that occur in response to the presence of critically short or damaged telomeres. [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:15279784]"}
{"concept_id": "C1523886", "aliases": ["proteasome maturation", "proteasome complex assembly"], "types": ["T044"], "canonical_name": "proteasome assembly", "definition": "The aggregation, arrangement and bonding together of a mature, active proteasome complex. [GOC:go_curators, PMID:10872471]"}
{"concept_id": "C1523887", "aliases": ["red blood cell maturation", "RBC maturation"], "types": ["T043"], "canonical_name": "erythrocyte maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. [GOC:devbiol, GOC:jl]"}
{"concept_id": "C1523888", "aliases": [], "types": ["T044"], "canonical_name": "sodium-dependent organic anion transmembrane transporter activity", "definition": "Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner. [GOC:go_curators]"}
{"concept_id": "C1523889", "aliases": [], "types": ["T043"], "canonical_name": "sodium-dependent organic anion transport", "definition": "The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]"}
{"concept_id": "C1523890", "aliases": [], "types": ["T043"], "canonical_name": "sodium-independent organic anion transport", "definition": "The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]"}
{"concept_id": "C1523891", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast ribosome", "definition": "A ribosome contained within a chloroplast. [GOC:ecd]"}
{"concept_id": "C1523892", "aliases": [], "types": ["T040"], "canonical_name": "regulation of protein complex assembly"}
{"concept_id": "C1523893", "aliases": ["regulation of carbohydrate synthesis", "regulation of carbohydrate biosynthesis", "regulation of carbohydrate anabolism", "regulation of carbohydrate formation"], "types": ["T043"], "canonical_name": "regulation of carbohydrate biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. [GOC:jl]"}
{"concept_id": "C1523894", "aliases": ["laminin complex location"], "types": ["T026"], "canonical_name": "laminin complex", "definition": "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes. [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354]"}
{"concept_id": "C1523897", "aliases": ["ATP diphosphohydrolase activity", "ATP-diphosphatase activity", "adenosine diphosphatase activity", "adenosine-diphosphatase activity", "ADPase"], "types": ["T044"], "definition": "Catalysis of the reaction: ADP + H2O = AMP + phosphate. [EC:3.6.1.5, PMID:1470606]", "canonical_name": "ADPase activity"}
{"concept_id": "C1523898", "aliases": ["extracellular non-membrane-enclosed organelle"], "types": ["T026"], "canonical_name": "extracellular non-membrane-bounded organelle", "definition": "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. [GOC:jl]"}
{"concept_id": "C1523899", "aliases": ["regulation of potassium ion transport", "regulation of K+ transport"], "types": ["T043"], "definition": "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "canonical_name": "regulation of potassium transport"}
{"concept_id": "C1523900", "aliases": ["negative regulation of K+ transport", "downregulation of potassium ion transport", "down regulation of potassium ion transport", "negative regulation of potassium ion transport", "down-regulation of potassium ion transport"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "canonical_name": "negative regulation of potassium transport"}
{"concept_id": "C1523901", "aliases": ["upregulation of potassium ion transport", "positive regulation of K+ transport", "up-regulation of potassium ion transport", "positive regulation of potassium transport", "up regulation of potassium ion transport"], "types": ["T043"], "canonical_name": "positive regulation of potassium ion transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1523902", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ion transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1523903", "aliases": ["up-regulation of ion transport", "upregulation of ion transport", "up regulation of ion transport"], "types": ["T043"], "canonical_name": "positive regulation of ion transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1523904", "aliases": ["down-regulation of ion transport", "downregulation of ion transport", "down regulation of ion transport"], "types": ["T043"], "canonical_name": "negative regulation of ion transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C1523905", "aliases": ["ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance", "ethylene formation during jasmonic acid and ethylene-dependent systemic resistance", "ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance"], "types": ["T044"], "canonical_name": "ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance"}
{"concept_id": "C1523906", "aliases": ["cytidine triphosphatase activity"], "types": ["T044"], "canonical_name": "CTPase activity", "definition": "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction. [GOC:go_curators]"}
{"concept_id": "C1523907", "aliases": [], "types": ["T044"], "canonical_name": "phospholipase binding", "definition": "Binding to a phospholipase. [GOC:jl]"}
{"concept_id": "C1523908", "aliases": ["programmed cell clearance", "efferocytosis", "apoptotic cell removal"], "types": ["T043"], "canonical_name": "apoptotic cell clearance", "definition": "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. [GOC:rk, PMID:14685684]"}
{"concept_id": "C1523909", "aliases": [], "types": ["T040"], "canonical_name": "response to morphine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. [GOC:ef, GOC:jl]"}
{"concept_id": "C1523910", "aliases": [], "types": ["T040"], "canonical_name": "response to alkaloid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. [GOC:jl]"}
{"concept_id": "C1523911", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of caspase activity"}
{"concept_id": "C1523912", "aliases": [], "types": ["T044"], "canonical_name": "regulation of caspase activation"}
{"concept_id": "C1523913", "aliases": [], "types": ["T042"], "canonical_name": "pharyngeal muscle development", "definition": "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx. [GOC:go_curators]"}
{"concept_id": "C1523917", "aliases": ["regulation of PHA", "regulation of poly(3-hydroxyalkanoate) biosynthesis", "regulation of poly(3-hydroxyalkanoate) synthesis", "regulation of poly(3-hydroxyalkanoate) anabolism", "regulation of poly(3-hydroxyalkanoate) formation"], "types": ["T044"], "canonical_name": "regulation of poly(3-hydroxyalkanoate) biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. [GOC:jl]"}
{"concept_id": "C1523918", "aliases": ["PHA binding"], "types": ["T044"], "canonical_name": "poly(3-hydroxyalkanoate) binding", "definition": "Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. [GOC:jl]"}
{"concept_id": "C1523919", "aliases": ["apo carotenoid metabolic process", "apocarotenoid metabolism"], "types": ["T044"], "canonical_name": "apocarotenoid metabolic process", "definition": "The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid. [GOC:jl]"}
{"concept_id": "C1523920", "aliases": ["apocarotenoid synthesis", "apocarotenoid anabolism", "apocarotenoid biosynthesis", "apocarotenoid formation", "apo carotenoid biosynthetic process"], "types": ["T044"], "canonical_name": "apocarotenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid. [GOC:jl, PMID:27485225]"}
{"concept_id": "C1523921", "aliases": ["apocarotenoid degradation", "apo carotenoid catabolic process", "apocarotenoid breakdown", "apocarotenoid catabolism"], "types": ["T044"], "canonical_name": "apocarotenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid. [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]"}
{"concept_id": "C1523922", "aliases": ["RAVE complex location"], "types": ["T026"], "canonical_name": "RAVE complex", "definition": "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme. [PMID:11283612, PMID:11844802]"}
{"concept_id": "C1523925", "aliases": ["primary metabolism"], "types": ["T040"], "canonical_name": "primary metabolic process", "definition": "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. [GOC:go_curators, http://www.metacyc.org]"}
{"concept_id": "C1523928", "aliases": [], "types": ["T040"], "canonical_name": "lipid digestion", "definition": "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. [GOC:go_curators]"}
{"concept_id": "C1523929", "aliases": ["cellular lipid breakdown", "cellular lipid degradation", "cellular lipid catabolism"], "types": ["T043"], "canonical_name": "cellular lipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1523932", "aliases": [], "types": ["T040"], "canonical_name": "polysaccharide digestion", "definition": "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism. [GOC:go_curators]"}
{"concept_id": "C1523934", "aliases": ["cellular polysaccharide breakdown", "cellular polysaccharide catabolism", "cellular polysaccharide degradation"], "types": ["T043"], "canonical_name": "cellular polysaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1523935", "aliases": ["cellular catabolism", "cellular degradation", "cellular breakdown"], "types": ["T043"], "canonical_name": "cellular catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1523936", "aliases": ["cellular synthesis", "cellular anabolism", "cellular formation", "cellular biosynthesis"], "types": ["T043"], "canonical_name": "cellular biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1523942", "aliases": ["cellular lipid metabolism"], "types": ["T043"], "canonical_name": "cellular lipid metabolic process", "definition": "The chemical reactions and pathways involving lipids, as carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1523943", "aliases": [], "types": ["T040"], "definition": "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism. [GOC:go_curators]", "canonical_name": "protein digestion"}
{"concept_id": "C1523945", "aliases": ["intestinal lipid breakdown", "intestinal lipid catabolism", "intestinal lipid degradation"], "types": ["T040"], "canonical_name": "intestinal lipid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. [GOC:jl, http://www.emc.maricopa.edu/]"}
{"concept_id": "C1523947", "aliases": ["cellular macromolecule metabolism", "cellular biopolymer metabolic process"], "types": ["T043"], "canonical_name": "cellular macromolecule metabolic process", "definition": "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. [GOC:mah]"}
{"concept_id": "C1523949", "aliases": ["cellular carbohydrate metabolism"], "types": ["T043"], "canonical_name": "cellular carbohydrate metabolic process", "definition": "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1523951", "aliases": ["cellular glycan metabolism", "cellular polysaccharide metabolism", "cellular glycan metabolic process"], "types": ["T043"], "canonical_name": "cellular polysaccharide metabolic process", "definition": "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1523952", "aliases": ["cellular macromolecule degradation", "cellular macromolecule catabolism", "cellular biopolymer catabolic process", "cellular macromolecule breakdown"], "types": ["T043"], "canonical_name": "cellular macromolecule catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1523956", "aliases": ["glycerol ether degradation", "glycerol ether breakdown", "glycerol ether catabolism"], "types": ["T044"], "canonical_name": "glycerol ether catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. [GOC:jl]"}
{"concept_id": "C1523957", "aliases": [], "types": ["T044"], "canonical_name": "cellular nitrogen compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1523958", "aliases": [], "types": ["T044"], "canonical_name": "cellular nitrogen compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1523959", "aliases": ["sulfur compound anabolism", "sulfur compound synthesis", "sulfur compound formation", "sulfur compound biosynthesis"], "types": ["T044"], "canonical_name": "sulfur compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. [GOC:jl]"}
{"concept_id": "C1523960", "aliases": ["sulfur compound catabolism", "sulfur compound degradation", "sulfur compound breakdown"], "types": ["T044"], "canonical_name": "sulfur compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. [GOC:jl]"}
{"concept_id": "C1523962", "aliases": ["cellular carbohydrate catabolism", "cellular carbohydrate degradation", "cellular carbohydrate breakdown"], "types": ["T043"], "canonical_name": "cellular carbohydrate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1523964", "aliases": ["protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence", "protein insertion into ER membrane, N-terminal cleaved signal sequence mediated", "protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence", "protein-ER insertion by N-terminal cleaved signal sequence", "N-terminal cleaved signal sequence mediated protein insertion into ER membrane"], "types": ["T043"], "canonical_name": "protein insertion into ER membrane by N-terminal cleaved signal sequence", "definition": "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER. [ISBN:0716731363]"}
{"concept_id": "C1523965", "aliases": ["stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane", "protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence", "protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated", "protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence", "protein-ER insertion by stop-transfer membrane-anchor sequence"], "types": ["T043"], "canonical_name": "protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "definition": "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix. [ISBN:0716731363]"}
{"concept_id": "C1523966", "aliases": ["protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence", "internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane", "protein-ER insertion by internal uncleaved signal-anchor sequence", "protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated", "protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence"], "types": ["T043"], "canonical_name": "protein insertion into ER membrane by internal uncleaved signal-anchor sequence", "definition": "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences. [ISBN:0716731363]"}
{"concept_id": "C1523967", "aliases": ["protein-ER insertion by GPI attachment sequence", "GPI attachment sequence mediated protein insertion into ER membrane", "protein-endoplasmic reticulum insertion by GPI attachment sequence", "protein insertion into endoplasmic reticulum membrane by GPI attachment sequence", "protein insertion into ER membrane, GPI attachment sequence mediated"], "types": ["T043"], "canonical_name": "protein insertion into ER membrane by GPI attachment sequence", "definition": "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule. [ISBN:0716731363]"}
{"concept_id": "C1523968", "aliases": [], "types": ["T043"], "canonical_name": "regulation of compound eye photoreceptor development", "definition": "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development. [GOC:bf]"}
{"concept_id": "C1523969", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of compound eye photoreceptor development", "definition": "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development. [GOC:bf]"}
{"concept_id": "C1523970", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of compound eye photoreceptor development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development. [GOC:bf]"}
{"concept_id": "C1524026", "aliases": ["cellular metabolic process"], "types": ["T043"], "definition": "The chemical reactions and pathways by which individual cells transform chemical substances. [GOC:go_curators]", "canonical_name": "cellular metabolism"}
{"concept_id": "C1524058", "aliases": [], "types": ["T043"], "definition": "Cell Migration Inhibition involves interference with, or restraint of, active directed translocation of a whole cell, or cell body, from one site to another in response to a gradient. (NCI)", "canonical_name": "inhibition of cell migration"}
{"concept_id": "C1524108", "aliases": ["septation initiation signaling cascade", "septation initiation network", "SIN", "septation initiation signaling"], "types": ["T043"], "definition": "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis. [GOC:mah, GOC:vw, PMID:16775007]", "canonical_name": "septation initiation signalling"}
{"concept_id": "C1524109", "aliases": [], "types": ["T038"], "definition": "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. [PMID:10611687, PMID:9706689]", "canonical_name": "segmentation"}
{"concept_id": "C1524120", "aliases": [], "types": ["T040"], "definition": "The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. [GOC:jid, PO:0009005]", "canonical_name": "root development"}
{"concept_id": "C1526984", "aliases": [], "types": ["T040"], "canonical_name": "detection of yeast", "definition": "The series of events in which a stimulus from a yeast is received and converted into a molecular signal. [PMID:14707091]"}
{"concept_id": "C1526985", "aliases": ["exon junction complex location", "exon-exon junction complex", "exon-exon junction complex location", "EJC"], "types": ["T026"], "definition": "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. [PMID:11532962, PMID:11743026]", "canonical_name": "exon junction complex"}
{"concept_id": "C1526987", "aliases": [], "types": ["T043"], "definition": "The process in which nucleated precursor cells lose their nucleus. [GOC:tb]", "canonical_name": "enucleation"}
{"concept_id": "C1526988", "aliases": ["regulation of nitric-oxide synthase activity", "regulation of NOS activity", "NOS regulator"], "types": ["T044"], "definition": "Any process that modulates the activity of the enzyme nitric-oxide synthase. [GOC:ai]", "canonical_name": "nitric-oxide synthase regulator"}
{"concept_id": "C1526989", "aliases": ["nuclear transport"], "types": ["T043"], "definition": "The directed movement of substances into, out of, or within the nucleus. [GOC:ai]", "canonical_name": "nucleus transport"}
{"concept_id": "C1527009", "aliases": [], "types": ["T026"], "definition": "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. [GOC:nln]", "canonical_name": "varicosity"}
{"concept_id": "C1527023", "aliases": ["down regulation of nitric-oxide synthase activity", "negative regulation of nitric-oxide synthase activity", "negative regulation of NOS activity", "downregulation of nitric-oxide synthase activity"], "types": ["T044"], "definition": "Any process that stops or reduces the activity of the enzyme nitric-oxide synthase. [GOC:ai]", "canonical_name": "down-regulation of nitric-oxide synthase activity"}
{"concept_id": "C1527040", "aliases": ["cell growth in three dimensions"], "types": ["T043"], "canonical_name": "multidimensional cell growth", "definition": "The process in which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes. [ISBN:0943088399]"}
{"concept_id": "C1527042", "aliases": [], "types": ["T043"], "canonical_name": "cell growth in two dimensions"}
{"concept_id": "C1527107", "aliases": ["NOS binding"], "types": ["T044"], "definition": "Binding to nitric-oxide synthase. [GOC:ai]", "canonical_name": "nitric-oxide synthase binding"}
{"concept_id": "C1527268", "aliases": [], "types": ["T026"], "definition": "A complex of protein and RNA which facilitates translocation of proteins across membranes. [GOC:mlg]", "canonical_name": "signal recognition particle"}
{"concept_id": "C1527269", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin. [ISBN:0721639976, PMID:19693541, PMID:21421911]", "canonical_name": "collagen type XVII trimer"}
{"concept_id": "C1527274", "aliases": [], "types": ["T026"], "definition": "A collagen homotrimer of alpha1(XVIII) chains. [ISBN:0721639976, PMID:21421911]", "canonical_name": "collagen type XVIII trimer"}
{"concept_id": "C1533692", "aliases": [], "types": ["T042"], "definition": "The emergence of a tooth from within its follicle in the ALVEOLAR PROCESS of the MAXILLA or MANDIBLE into the ORAL CAVITY. (Boucher's Clinical Dental Terminology, 4th ed)", "canonical_name": "tooth eruption"}
{"concept_id": "C1533729", "aliases": [], "types": ["T045"], "canonical_name": "transcription activator activity", "definition": "OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription. [GOC:jl, ISBN:0124325653]"}
{"concept_id": "C1533730", "aliases": ["sodium/neurotransmitter symporter activity"], "types": ["T044"], "canonical_name": "neurotransmitter:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). [TC:2.A.22.-.-]"}
{"concept_id": "C1533731", "aliases": [], "types": ["T044"], "canonical_name": "calcium activated cation channel activity", "definition": "Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. [GOC:dph, GOC:mtg_transport]"}
{"concept_id": "C1536403", "aliases": ["cytolysis"], "types": ["T043"], "definition": "The rupture of cell membranes and the loss of cytoplasm. [UniProtKB-KW:KW-0204]", "canonical_name": "lysis"}
{"concept_id": "C1563744", "aliases": ["lipogenesis", "lipid formation", "lipid biosynthesis", "lipid biosynthetic process", "lipid synthesis"], "types": ["T040"], "definition": "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]", "canonical_name": "lipid anabolism"}
{"concept_id": "C1566300", "aliases": [], "types": ["T043"], "canonical_name": "bacterial conjugation"}
{"concept_id": "C1571130", "aliases": ["D-threo-tetrahydrobiopterin", "tetrahydrodictyopterin binding"], "types": ["T044"], "definition": "Binding to tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one. [GOC:mah, GOC:vw]", "canonical_name": "DH4 binding"}
{"concept_id": "C1608376", "aliases": ["erythrocyte aggregation", "RBC aggregation"], "types": ["T043"], "definition": "The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules. [GOC:add, PMID:14631543]", "canonical_name": "red blood cell aggregation"}
{"concept_id": "C1621259", "aliases": ["ribosomal DNA binding"], "types": ["T045"], "canonical_name": "rDNA binding", "definition": "Binding to a DNA sequence encoding a ribosomal RNA. [GOC:mah]"}
{"concept_id": "C1621261", "aliases": ["spliceosomal commitment complex formation"], "types": ["T045"], "canonical_name": "spliceosomal commitment complex formation"}
{"concept_id": "C1621266", "aliases": ["3',5' cAMP receptor activity", "3',5'-cAMP receptor activity", "cyclic AMP receptor activity", "adenosine 3',5'-cyclophosphate receptor activity"], "types": ["T044"], "canonical_name": "cAMP receptor activity", "definition": "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:pg]"}
{"concept_id": "C1621267", "aliases": ["class E G protein coupled receptor", "class E G-protein coupled receptor"], "types": ["T044"], "canonical_name": "class E GPCR"}
{"concept_id": "C1621269", "aliases": ["up regulation of endothelial cell proliferation", "up-regulation of endothelial cell proliferation", "upregulation of endothelial cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of endothelial cell proliferation", "definition": "Any process that activates or increases the rate or extent of endothelial cell proliferation. [GOC:add]"}
{"concept_id": "C1621270", "aliases": ["vascular system development"], "types": ["T042"], "canonical_name": "vasculature development", "definition": "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. [GOC:dph, UBERON:0002409]"}
{"concept_id": "C1621273", "aliases": ["down regulation of endothelial cell proliferation", "down-regulation of endothelial cell proliferation", "downregulation of endothelial cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell proliferation", "definition": "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. [GOC:add]"}
{"concept_id": "C1621275", "aliases": [], "types": ["T042"], "canonical_name": "blood vessel maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. [GOC:dph]"}
{"concept_id": "C1621276", "aliases": [], "types": ["T044"], "canonical_name": "fibronectin binding", "definition": "Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. [GOC:hjd]"}
{"concept_id": "C1621277", "aliases": ["regulation of membrane attack complex assembly", "regulation of MAC assembly", "regulation of activation of MAC", "regulation of membrane attack complex formation", "regulation of MAC formation"], "types": ["T043"], "canonical_name": "regulation of activation of membrane attack complex", "definition": "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. [GOC:hjd]"}
{"concept_id": "C1621278", "aliases": ["upregulation of cell-matrix adhesion", "up-regulation of cell-matrix adhesion", "up regulation of cell-matrix adhesion"], "types": ["T026"], "canonical_name": "positive regulation of cell-matrix adhesion", "definition": "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. [GOC:hjd]"}
{"concept_id": "C1621280", "aliases": [], "types": ["T039"], "canonical_name": "detection of renal blood flow", "definition": "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal. [ISBN:0721643949]"}
{"concept_id": "C1621281", "aliases": ["secretion of vasopressin during fast regulation of systemic arterial blood pressure"], "types": ["T043"], "canonical_name": "secretion of vasopressin during fast control of blood pressure"}
{"concept_id": "C1621284", "aliases": ["negative control of heart contraction rate in baroreceptor response to increased blood pressure", "downregulation of heart contraction rate in baroreceptor response to increased blood pressure", "down regulation of heart contraction rate in baroreceptor response to increased blood pressure", "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure", "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure"], "types": ["T039"], "canonical_name": "negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure. [ISBN:0721643949]"}
{"concept_id": "C1621285", "aliases": [], "types": ["T040"], "canonical_name": "angiotensin maturation", "definition": "The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood. [ISBN:0721643949]"}
{"concept_id": "C1621286", "aliases": [], "types": ["T039"], "canonical_name": "aldosterone mediated control of body fluids"}
{"concept_id": "C1621287", "aliases": [], "types": ["T044"], "canonical_name": "antibody"}
{"concept_id": "C1621290", "aliases": [], "types": ["T039"], "canonical_name": "reduction of food intake in response to dietary excess", "definition": "An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients. [GOC:pg, GOC:pr, PMID:12161655, PMID:12840200]"}
{"concept_id": "C1621291", "aliases": ["class D G-protein coupled receptor activity", "class D G protein coupled receptor activity", "class D G-protein-coupled receptor activity", "class D GPCR activity"], "types": ["T044"], "canonical_name": "class D GPCR activity"}
{"concept_id": "C1621293", "aliases": ["arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway", "desensitization of G-protein coupled receptor protein signaling pathway by arrestin", "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway", "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway"], "types": ["T043"], "canonical_name": "desensitization of G protein-coupled receptor signaling pathway by arrestin", "definition": "The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins. [GOC:dph, GOC:tb, PMID:8396717]"}
{"concept_id": "C1621296", "aliases": [], "types": ["T044"], "canonical_name": "receptor ligand"}
{"concept_id": "C1621302", "aliases": ["valine/tyrosine/tryptophan permease activity"], "types": ["T044"], "canonical_name": "valine/tyrosine/tryptophan permease activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1621314", "aliases": ["CPF complex location"], "types": ["T026"], "canonical_name": "CPF complex"}
{"concept_id": "C1621315", "aliases": [], "types": ["T044"], "canonical_name": "purine metabolism"}
{"concept_id": "C1621319", "aliases": ["spliceosomal E complex formation"], "types": ["T045"], "canonical_name": "spliceosomal E complex formation"}
{"concept_id": "C1621321", "aliases": [], "types": ["T044"], "canonical_name": "receptor shedding"}
{"concept_id": "C1621323", "aliases": ["membrane protein solubilization"], "types": ["T044"], "canonical_name": "membrane protein solubilization"}
{"concept_id": "C1621325", "aliases": ["protein amino acid O-linked glycosylation"], "types": ["T044"], "canonical_name": "protein O-linked glycosylation", "definition": "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]"}
{"concept_id": "C1621326", "aliases": ["sesquiterpene metabolism"], "types": ["T044"], "canonical_name": "sesquiterpene metabolic process", "definition": "The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. [GOC:ai]"}
{"concept_id": "C1621327", "aliases": [], "types": ["T044"], "definition": "Compounds that bind to and inhibit the action of ADENYLYL CYCLASES.", "canonical_name": "adenylate cyclase inhibitor"}
{"concept_id": "C1621328", "aliases": [], "types": ["T045"], "canonical_name": "nuclear genome maintenance"}
{"concept_id": "C1621331", "aliases": ["ocellus pigment granule organisation", "ocellus pigment granule organization and biogenesis"], "types": ["T043"], "canonical_name": "ocellus pigment granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm]"}
{"concept_id": "C1621333", "aliases": ["response to thermal stimulus"], "types": ["T038"], "canonical_name": "response to temperature stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. [GOC:hb]"}
{"concept_id": "C1621334", "aliases": ["phytochrome signaling pathway"], "types": ["T044"], "canonical_name": "phytochrome signaling pathway"}
{"concept_id": "C1621335", "aliases": ["GABA catabolism", "4-aminobutyrate catabolic process", "4-aminobutyrate catabolism", "gamma-aminobutyric acid catabolism", "4-aminobutanoate catabolic process", "gamma-aminobutyric acid breakdown", "gamma-aminobutyric acid degradation", "GABA catabolic process", "4-aminobutanoate catabolism"], "types": ["T044"], "canonical_name": "gamma-aminobutyric acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [GOC:ai]"}
{"concept_id": "C1621343", "aliases": [], "types": ["T044"], "canonical_name": "NADH dehydrogenase complex (plastoquinone) assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I. [PMID:15608332]"}
{"concept_id": "C1621345", "aliases": ["S-methylmethionine synthesis", "S-methylmethionine formation", "S-methylmethionine biosynthesis", "S-methylmethionine anabolism"], "types": ["T044"], "canonical_name": "S-methylmethionine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle. [PMID:12692340]"}
{"concept_id": "C1621350", "aliases": ["nitrate ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type nitrate transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in). [RHEA:13181]"}
{"concept_id": "C1621351", "aliases": ["taurine ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type taurine transporter transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in). [RHEA:14613]"}
{"concept_id": "C1621354", "aliases": ["isopentenyl diphosphate synthesis, mevalonate pathway", "isopentenyl diphosphate biosynthetic process via mevalonate", "acetate-mevalonate pathway", "isopentenyl diphosphate formation, mevalonate pathway", "Ac-MVA pathway", "isopentenyl diphosphate anabolism, mevalonate pathway"], "types": ["T044"], "canonical_name": "isopentenyl diphosphate biosynthetic process, mevalonate pathway", "definition": "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates. [GOC:go_curators, MetaCyc:PWY-922]"}
{"concept_id": "C1621356", "aliases": [], "types": ["T044"], "canonical_name": "arsenite ABC transporter"}
{"concept_id": "C1621357", "aliases": [], "types": ["T043"], "canonical_name": "phloem transport", "definition": "The directed movement of substances, into, out of or within the phloem during long distance transport between source and sink tissues. [GOC:sm, PMID:19025382]"}
{"concept_id": "C1621360", "aliases": [], "types": ["T044"], "canonical_name": "heme ABC transporter"}
{"concept_id": "C1621361", "aliases": ["guard mother cell division"], "types": ["T043"], "canonical_name": "guard mother cell cytokinesis", "definition": "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells. [GOC:tb]"}
{"concept_id": "C1621363", "aliases": [], "types": ["T044"], "canonical_name": "long-chain fatty acid delta(6)-desaturase activity"}
{"concept_id": "C1621365", "aliases": [], "types": ["T044"], "canonical_name": "tetraterpene metabolism"}
{"concept_id": "C1621367", "aliases": ["cytoplasmic membrane-enclosed vesicle", "cytoplasmic, membrane-bounded vesicle"], "types": ["T026"], "canonical_name": "cytoplasmic membrane bounded vesicle"}
{"concept_id": "C1621370", "aliases": ["protein amino acid O-linked glycosylation via hydroxyproline"], "types": ["T044"], "canonical_name": "protein O-linked glycosylation via hydroxyproline", "definition": "The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline. [RESID:AA0212]"}
{"concept_id": "C1621371", "aliases": ["protein amino acid O-linked glycosylation via threonine"], "types": ["T044"], "canonical_name": "protein O-linked glycosylation via threonine", "definition": "The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine. [RESID:AA0155]"}
{"concept_id": "C1621376", "aliases": [], "types": ["T044"], "canonical_name": "methylglyoxal detoxification"}
{"concept_id": "C1621377", "aliases": [], "types": ["T044"], "canonical_name": "ribitol utilization"}
{"concept_id": "C1621380", "aliases": [], "types": ["T044"], "canonical_name": "D-arabitol utilization"}
{"concept_id": "C1621384", "aliases": ["cytoadherence to microvasculature, mediated by parasite protein", "adhesion of symbiont to microvasculature", "parasite-protein-mediated cytoadherence to microvasculature", "symbiont-protein-mediated cytoadherence to microvasculature"], "types": ["T044"], "definition": "The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte. [GOC:mb, PMID:10362584]", "canonical_name": "cytoadherence to microvasculature, mediated by symbiont protein"}
{"concept_id": "C1621385", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-17E receptor ligand"}
{"concept_id": "C1621386", "aliases": [], "types": ["T042"], "canonical_name": "ovarian follicle cell stalk formation", "definition": "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:10822261]"}
{"concept_id": "C1621393", "aliases": [], "types": ["T042"], "canonical_name": "fin regeneration", "definition": "The regrowth of fin tissue following its loss or destruction. [GOC:dgh]"}
{"concept_id": "C1621395", "aliases": ["SAPK signalling pathway", "SAPK signaling pathway", "stress-activated protein kinase signalling pathway", "stress-activated protein kinase signaling pathway"], "types": ["T044"], "canonical_name": "stress-activated protein kinase signaling cascade", "definition": "The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal. [GOC:mah]"}
{"concept_id": "C1621396", "aliases": ["JNK signalling pathway"], "types": ["T044"], "canonical_name": "JNK signaling pathway"}
{"concept_id": "C1621397", "aliases": [], "types": ["T026"], "canonical_name": "platelet dense granule lumen", "definition": "The volume enclosed by the membrane of the platelet dense granule. [GOC:mah]"}
{"concept_id": "C1621398", "aliases": [], "types": ["T043"], "canonical_name": "microtubule polymerization or depolymerization", "definition": "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. [GOC:mah]"}
{"concept_id": "C1621399", "aliases": ["proteasome localisation", "establishment and maintenance of proteasome localization"], "types": ["T043"], "canonical_name": "proteasome localization", "definition": "Any process in which the proteasome is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C1621400", "aliases": ["up regulation of microtubule polymerization", "upregulation of microtubule polymerization", "up-regulation of microtubule polymerization"], "types": ["T043"], "canonical_name": "positive regulation of microtubule polymerization", "definition": "Any process that activates or increases the frequency, rate or extent of microtubule polymerization. [GOC:mah]"}
{"concept_id": "C1621401", "aliases": ["equatorial microtubule organization and biogenesis", "equatorial microtubule organisation"], "types": ["T043"], "canonical_name": "equatorial microtubule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell. [GOC:mah, GOC:vw]"}
{"concept_id": "C1621402", "aliases": [], "types": ["T043"], "canonical_name": "creation of an inductive signal", "definition": "The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter. [GOC:mah]"}
{"concept_id": "C1621403", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA 3'-end processing"}
{"concept_id": "C1621404", "aliases": [], "types": ["T043"], "canonical_name": "reception of an inductive signal", "definition": "The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change. [GOC:mah]"}
{"concept_id": "C1621405", "aliases": [], "types": ["T043"], "canonical_name": "induction of conjugation upon nutrient starvation", "definition": "The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients. [GOC:mah]"}
{"concept_id": "C1621406", "aliases": [], "types": ["T044"], "canonical_name": "siderophore biosynthetic process, peptide modification"}
{"concept_id": "C1621407", "aliases": [], "types": ["T044"], "canonical_name": "ferrichrome biosynthetic process, peptide modification"}
{"concept_id": "C1621408", "aliases": ["anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process", "APC-dependent proteasomal ubiquitin-dependent protein catabolism", "APC-dependent proteasomal ubiquitin-dependent protein catabolic process", "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown", "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation", "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism"], "types": ["T044"], "canonical_name": "anaphase-promoting complex-dependent catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. [GOC:mah, PMID:15380083, PMID:15840442]"}
{"concept_id": "C1621409", "aliases": ["ferrichrome metabolism"], "types": ["T044"], "canonical_name": "ferrichrome metabolic process", "definition": "The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1621412", "aliases": ["contractile vacuole membrane"], "types": ["T026"], "canonical_name": "contractile vacuolar membrane", "definition": "The lipid bilayer surrounding the contractile vacuole. [GOC:pg]"}
{"concept_id": "C1621414", "aliases": [], "types": ["T044"], "canonical_name": "pyochelin biosynthetic process, peptide formation"}
{"concept_id": "C1621415", "aliases": [], "types": ["T040"], "canonical_name": "regulation of sorocarp development", "definition": "Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum. [GOC:mah, GOC:mtg_sensu, PMID:4332228]"}
{"concept_id": "C1621417", "aliases": ["2,6-beta-D-fructan fructanohydrolase activity", "levan hydrolase activity"], "types": ["T044"], "canonical_name": "levanase activity", "definition": "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units. [EC:3.2.1.65, GOC:mlg]"}
{"concept_id": "C1621418", "aliases": ["RSF complex location", "remodeling and spacing factor complex", "remodeling and spacing factor complex location"], "types": ["T026"], "canonical_name": "RSF complex", "definition": "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters). [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179]"}
{"concept_id": "C1621420", "aliases": ["ferricrocin synthesis", "ferricrocin anabolism", "ferricrocin biosynthesis", "ferricrocin formation"], "types": ["T044"], "canonical_name": "ferricrocin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3. [GOC:mah, PMID:12828635]"}
{"concept_id": "C1621421", "aliases": ["endoplasmic reticulum Sec complex location"], "types": ["T026"], "canonical_name": "endoplasmic reticulum Sec complex", "definition": "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex. [GOC:mtg_sensu, PMID:14617809]"}
{"concept_id": "C1621422", "aliases": [], "types": ["T044"], "canonical_name": "maltodextrin phosphorylase activity", "definition": "Catalysis of the reaction: maltodextrin = glucose-1-phosphate. [GOC:mlg, PMID:10348846]"}
{"concept_id": "C1621424", "aliases": ["auditory behaviour", "behavioral response to sound", "behavioural response to sound"], "types": ["T038"], "canonical_name": "auditory behavior", "definition": "The behavior of an organism in response to a sound. [GOC:pr, GOC:rc]"}
{"concept_id": "C1621426", "aliases": [], "types": ["T043"], "canonical_name": "actin rod formation"}
{"concept_id": "C1621427", "aliases": ["intrinsic to periplasmic side of plasma membrane", "intrinsic to external leaflet of plasma membrane, in periplasmic space"], "types": ["T026"], "canonical_name": "intrinsic component of periplasmic side of plasma membrane", "definition": "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1621428", "aliases": ["intrinsic to nuclear inner membrane"], "types": ["T026"], "canonical_name": "intrinsic component of nuclear inner membrane", "definition": "The component of the nuclear inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1621429", "aliases": ["negative regulation of cellular formation", "down regulation of cellular biosynthetic process", "negative regulation of cellular biosynthesis", "down-regulation of cellular biosynthetic process", "negative regulation of cellular anabolism", "negative regulation of cellular synthesis", "downregulation of cellular biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of cellular biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. [GOC:mah]"}
{"concept_id": "C1621432", "aliases": ["trailing edge", "back of cell"], "types": ["T026"], "canonical_name": "cell trailing edge", "definition": "The area of a motile cell opposite to the direction of movement. [GOC:pg]"}
{"concept_id": "C1621433", "aliases": ["leading edge of cell", "front of cell"], "types": ["T026"], "canonical_name": "cell leading edge", "definition": "The area of a motile cell closest to the direction of movement. [GOC:pg]"}
{"concept_id": "C1621434", "aliases": [], "types": ["T026"], "canonical_name": "lamellipodium membrane", "definition": "The portion of the plasma membrane surrounding a lamellipodium. [GOC:mah]"}
{"concept_id": "C1621435", "aliases": [], "types": ["T043"], "canonical_name": "pseudopodium retraction", "definition": "The myosin-based contraction and retraction of a pseudopodium. [GOC:pg]"}
{"concept_id": "C1621437", "aliases": ["Ndc80 complex location", "Nuf2-Ndc80 complex", "Nuf2-Ndc80 complex location"], "types": ["T026"], "canonical_name": "Ndc80 complex", "definition": "An outer kinetochore protein complex that is part of the KMN kinetochore network (also known as the NMS complex) providing the platform with which the plus ends of spindle microtubules directly interact to form stable kinetochore-microtubule attachments. A common subunit nomenclature is used from yeast to human: Ndc80, Nuf2, Spc24, and Spc25. [GOC:krc, GOC:vw, PMID:15509863, PMID:15661517, PMID:28502666]"}
{"concept_id": "C1621438", "aliases": [], "types": ["T043"], "canonical_name": "lateral pseudopodium formation"}
{"concept_id": "C1621439", "aliases": ["pseudopodium organization and biogenesis", "pseudopodium organisation"], "types": ["T043"], "canonical_name": "pseudopodium organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. [GOC:pg]"}
{"concept_id": "C1621443", "aliases": ["death receptor-induced signaling complex location", "death-inducing signalling complex location", "death-inducing signaling complex", "DISC protein complex location", "death receptor-induced signaling complex", "death receptor-induced signalling complex", "DISC protein complex", "death receptor-induced signalling complex location", "DISC", "death-inducing signaling complex location"], "types": ["T026"], "definition": "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. [GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815]", "canonical_name": "death-inducing signalling complex"}
{"concept_id": "C1621444", "aliases": ["upregulation of guanylate cyclase activity", "up regulation of guanylate cyclase activity", "up-regulation of guanylate cyclase activity"], "types": ["T044"], "canonical_name": "positive regulation of guanylate cyclase activity", "definition": "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. [GOC:mah]"}
{"concept_id": "C1621445", "aliases": [], "types": ["T044"], "canonical_name": "actin phosphorylation", "definition": "The transfer of one or more phosphate groups to an actin molecule. [GOC:mah]"}
{"concept_id": "C1621450", "aliases": ["TRAP transporter complex", "TRAP-T transporter complex location", "TRAP transporter complex location", "TRAP-T transporter complex", "tripartite ATP-independent periplasmic transporter complex location"], "types": ["T026"], "canonical_name": "tripartite ATP-independent periplasmic transporter complex", "definition": "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients. [GOC:mlg]"}
{"concept_id": "C1621451", "aliases": ["extrinsic to mitochondrial outer membrane"], "types": ["T026"], "canonical_name": "extrinsic component of mitochondrial outer membrane", "definition": "The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]"}
{"concept_id": "C1621452", "aliases": ["intrinsic to nuclear outer membrane"], "types": ["T026"], "canonical_name": "intrinsic component of nuclear outer membrane", "definition": "The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1621453", "aliases": ["Swi1-Swi3 complex location"], "types": ["T026"], "canonical_name": "Swi1-Swi3 complex"}
{"concept_id": "C1621454", "aliases": ["integral to mitochondrial inner membrane"], "types": ["T026"], "canonical_name": "integral component of mitochondrial inner membrane", "definition": "The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1621455", "aliases": ["integral to organelle membrane"], "types": ["T026"], "canonical_name": "integral component of organelle membrane", "definition": "The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1621456", "aliases": ["down regulation of vesicle fusion", "downregulation of vesicle fusion", "down-regulation of vesicle fusion"], "types": ["T043"], "canonical_name": "negative regulation of vesicle fusion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. [GOC:mah]"}
{"concept_id": "C1621457", "aliases": ["integral to plastid inner membrane"], "types": ["T026"], "canonical_name": "integral component of plastid inner membrane", "definition": "The component of the plastid inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1621458", "aliases": ["regulation of cell projection organization and biogenesis", "regulation of cell projection organisation"], "types": ["T043"], "canonical_name": "regulation of cell projection organization", "definition": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. [GOC:mah]"}
{"concept_id": "C1621459", "aliases": [], "types": ["T040"], "canonical_name": "regulation of defense response", "definition": "Any process that modulates the frequency, rate or extent of a defense response. [GOC:mah]"}
{"concept_id": "C1621460", "aliases": ["up-regulation of cell killing", "up regulation of cell killing", "upregulation of cell killing"], "types": ["T043"], "canonical_name": "positive regulation of cell killing", "definition": "Any process that activates or increases the frequency, rate or extent of cell killing. [GOC:mah]"}
{"concept_id": "C1621461", "aliases": ["ubiquitin conjugating enzyme complex location"], "types": ["T026"], "canonical_name": "ubiquitin conjugating enzyme complex", "definition": "Any complex that possesses ubiquitin conjugating enzyme activity. [GOC:mah]"}
{"concept_id": "C1621463", "aliases": [], "types": ["T043"], "canonical_name": "regulation of initiation of mating projection growth", "definition": "Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi. [PMID:14734532]"}
{"concept_id": "C1621467", "aliases": ["Ctf18-RFC", "Ctf18 RFC-like complex location", "Ctf18-RLC", "RFC (Ctf18)"], "types": ["T026"], "canonical_name": "Ctf18 RFC-like complex", "definition": "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. [PMID:14614842]"}
{"concept_id": "C1621468", "aliases": ["integral to chloroplast outer membrane"], "types": ["T026"], "canonical_name": "integral component of chloroplast outer membrane", "definition": "The component of the chloroplast outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1621469", "aliases": [], "types": ["T044"], "definition": "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]", "canonical_name": "regulation of protein ubiquitination"}
{"concept_id": "C1621471", "aliases": ["Na+ ion binding"], "types": ["T044"], "canonical_name": "sodium ion binding", "definition": "Binding to a sodium ion (Na+). [GOC:mah]"}
{"concept_id": "C1621473", "aliases": [], "types": ["T044"], "canonical_name": "carboxylic acid binding", "definition": "Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-). [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1621475", "aliases": ["vitamin B12 binding"], "types": ["T044"], "canonical_name": "cobalamin binding", "definition": "Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. [GOC:mah]"}
{"concept_id": "C1621476", "aliases": [], "types": ["T026"], "canonical_name": "invertasome", "definition": "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts. [PMID:11114897, PMID:9732277]"}
{"concept_id": "C1621478", "aliases": ["MAPKK binding"], "types": ["T044"], "canonical_name": "mitogen-activated protein kinase kinase binding", "definition": "Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase. [GOC:mah]"}
{"concept_id": "C1621479", "aliases": ["upregulation of mRNA cleavage", "up regulation of mRNA cleavage", "up-regulation of mRNA cleavage"], "types": ["T045"], "canonical_name": "positive regulation of mRNA cleavage", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA cleavage. [GOC:mah]"}
{"concept_id": "C1621480", "aliases": ["down-regulation of mRNA 3'-end processing", "down regulation of mRNA 3'-end processing", "downregulation of mRNA 3'-end processing"], "types": ["T045"], "canonical_name": "negative regulation of mRNA 3'-end processing", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing. [GOC:mah]"}
{"concept_id": "C1621486", "aliases": ["down-regulation of mRNA cleavage", "down regulation of mRNA cleavage", "downregulation of mRNA cleavage"], "types": ["T045"], "canonical_name": "negative regulation of mRNA cleavage", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage. [GOC:mah]"}
{"concept_id": "C1621489", "aliases": ["Cul3-RING ubiquitin ligase complex location", "cullin-RING ligase 3", "CDL3 complex location", "BCR3 complex", "BC3B complex location", "CRL3 complex location", "BCR3 complex location", "CDL3 complex", "CRL3 complex", "BC3B complex"], "types": ["T026"], "canonical_name": "Cul3-RING ubiquitin ligase complex", "definition": "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1621491", "aliases": [], "types": ["T044"], "canonical_name": "betaine ABC transporter"}
{"concept_id": "C1621492", "aliases": ["VBC complex location"], "types": ["T026"], "canonical_name": "VBC complex"}
{"concept_id": "C1621493", "aliases": ["polyhedral organelle", "MCP", "BMC", "BAC"], "types": ["T026"], "definition": "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy. [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081, PMID:34058518, PMID:34340100]", "canonical_name": "bacterial microcompartment"}
{"concept_id": "C1621494", "aliases": ["menthol formation", "menthol biosynthesis", "menthol anabolism", "menthol synthesis"], "types": ["T044"], "canonical_name": "menthol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol. [GOC:mah]"}
{"concept_id": "C1621496", "aliases": [], "types": ["T044"], "canonical_name": "myosin V binding", "definition": "Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1621497", "aliases": ["SCF3 complex location"], "types": ["T026"], "canonical_name": "SCF3 complex"}
{"concept_id": "C1621498", "aliases": [], "types": ["T044"], "canonical_name": "polyubiquitin modification-dependent protein binding", "definition": "Binding to a protein upon poly-ubiquitination of the target protein. [GOC:pg]"}
{"concept_id": "C1621499", "aliases": ["nuclear proteasome complex location"], "types": ["T026"], "canonical_name": "nuclear proteasome complex", "definition": "A proteasome found in the nucleus of a cell. [GOC:mah]"}
{"concept_id": "C1621500", "aliases": ["'plasma membrane, cell tip'"], "types": ["T026"], "canonical_name": "plasma membrane of cell tip", "definition": "The portion of the plasma membrane surrounding the cell tip. [GOC:mah]"}
{"concept_id": "C1621501", "aliases": ["Snf1 serine/threonine protein kinase complex location", "Snf1 serine/threonine protein kinase complex", "Snf1 kinase complex location"], "types": ["T026"], "canonical_name": "Snf1 kinase complex"}
{"concept_id": "C1621502", "aliases": [], "types": ["T043"], "canonical_name": "minus-end directed microtubule sliding", "definition": "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules. [GOC:mah, GOC:vw]"}
{"concept_id": "C1621503", "aliases": ["positive regulation of anthocyanin metabolism", "up-regulation of anthocyanin metabolic process", "upregulation of anthocyanin metabolic process", "up regulation of anthocyanin metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of anthocyanin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. [GOC:mah]"}
{"concept_id": "C1621504", "aliases": ["positive regulation of anthocyanin synthesis", "up regulation of anthocyanin biosynthetic process", "positive regulation of anthocyanin formation", "up-regulation of anthocyanin biosynthetic process", "positive regulation of anthocyanin anabolism", "positive regulation of anthocyanin biosynthesis", "upregulation of anthocyanin biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of anthocyanin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins. [GOC:mah]"}
{"concept_id": "C1621505", "aliases": [], "types": ["T044"], "canonical_name": "HIF-type prolyl 4-hydroxylase"}
{"concept_id": "C1621506", "aliases": ["signal transduction involved in DNA integrity checkpoint", "DNA integrity checkpoint"], "types": ["T043"], "canonical_name": "DNA integrity checkpoint signaling", "definition": "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1621507", "aliases": ["SOC", "mitotic spindle orientation checkpoint signaling", "mitotic spindle orientation checkpoint", "signal transduction involved in mitotic cell cycle spindle orientation checkpoint", "mitotic cell cycle spindle orientation checkpoint", "spindle position checkpoint"], "types": ["T043"], "definition": "A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected. [GOC:mtg_cell_cycle, PMID:14616062]", "canonical_name": "SPOC"}
{"concept_id": "C1621509", "aliases": ["yW metabolic process", "wybutosine metabolism", "yW metabolism"], "types": ["T044"], "canonical_name": "wybutosine metabolic process", "definition": "The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules. [GOC:mah, RNAmods:037]"}
{"concept_id": "C1621510", "aliases": ["GnRH receptor binding", "gonadotrophin-releasing hormone receptor binding"], "types": ["T044"], "canonical_name": "gonadotropin-releasing hormone receptor binding", "definition": "Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. [GOC:pr, PMID:15196882]"}
{"concept_id": "C1621511", "aliases": ["2,3-oxidosqualene cyclase activity"], "types": ["T044"], "canonical_name": "oxidosqualene cyclase activity", "definition": "Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene. [GOC:ct]"}
{"concept_id": "C1621512", "aliases": ["mitotic cell cycle cell size control checkpoint"], "types": ["T043"], "canonical_name": "mitotic cell size control checkpoint"}
{"concept_id": "C1621513", "aliases": ["mitotic cell cycle G1/S transition size control checkpoint", "mitotic G1 cell size control checkpoint", "G1 cell size control checkpoint"], "types": ["T043"], "canonical_name": "mitotic G1 cell size control checkpoint signaling", "definition": "A signal transduction process that contributes to a cell size control checkpoint during the G1/S transition of the cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1621514", "aliases": [], "types": ["T043"], "canonical_name": "hemidesmosome assembly", "definition": "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. [GOC:dgh, PMID:15983403]"}
{"concept_id": "C1621515", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-proline dioxygenase activity", "definition": "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]"}
{"concept_id": "C1621516", "aliases": [], "types": ["T044"], "canonical_name": "red light photoreceptor activity", "definition": "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation. [GOC:nln]"}
{"concept_id": "C1621517", "aliases": ["yW biosynthetic process", "yW biosynthesis"], "types": ["T045"], "canonical_name": "wybutosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules. [GOC:hjd, GOC:mah, RNAmods:037]"}
{"concept_id": "C1621520", "aliases": ["Mis6 centromere subcomplex location"], "types": ["T026"], "canonical_name": "Mis6 centromere subcomplex"}
{"concept_id": "C1621521", "aliases": ["motile primary cilia"], "types": ["T026"], "canonical_name": "motile primary cilium"}
{"concept_id": "C1621522", "aliases": ["protein O-mannosyltransferase complex", "protein O-mannosyltransferase complex location", "dolichyl-phosphate-mannose-protein mannosyltransferase complex location"], "types": ["T026"], "canonical_name": "dolichyl-phosphate-mannose-protein mannosyltransferase complex", "definition": "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies. [GOC:mah, GOC:pr, PMID:15948957]"}
{"concept_id": "C1621523", "aliases": ["protein complex localisation", "protein complex localization", "establishment and maintenance of protein complex localization"], "types": ["T043"], "canonical_name": "protein-containing complex localization", "definition": "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C1621524", "aliases": ["transcriptional gene silencing", "establishment of heterochromatin architecture", "chromatin-mediated silencing", "heterochromatin assembly", "heterochromatin formation", "chromatin silencing"], "types": ["T045"], "definition": "An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. [GOC:mah, PMID:25192661, PMID:33827924]", "canonical_name": "TGS"}
{"concept_id": "C1621525", "aliases": ["Sim4 complex location", "Mis6-Mal2-Sim4 centromere complex location", "Mis6-Sim4 complex location", "Sim4 complex", "Mis6-Mal2-Sim4 centromere complex"], "types": ["T026"], "canonical_name": "Mis6-Sim4 complex", "definition": "A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. [GOC:vw, PMID:12719471, PMID:15897182]"}
{"concept_id": "C1621527", "aliases": ["nuclear proteasome core complex, alpha-subunit complex location"], "types": ["T026"], "canonical_name": "nuclear proteasome core complex, alpha-subunit complex", "definition": "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell. [GOC:mah]"}
{"concept_id": "C1621528", "aliases": ["synaptic vesicle fusion to presynaptic membrane", "synaptic vesicle fusion to pre-synaptic membrane"], "types": ["T043"], "canonical_name": "synaptic vesicle fusion to presynaptic active zone membrane", "definition": "Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]"}
{"concept_id": "C1621530", "aliases": ["nuclear proteasome regulatory particle, base subcomplex location"], "types": ["T026"], "canonical_name": "nuclear proteasome regulatory particle, base subcomplex", "definition": "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell. [GOC:mah]"}
{"concept_id": "C1621533", "aliases": ["t-loop biosynthesis", "t-loop formation", "T loop biosynthesis", "T loop formation"], "types": ["T045"], "canonical_name": "telomeric loop formation", "definition": "The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region. [GOC:vw, PMID:10338214]"}
{"concept_id": "C1621535", "aliases": ["negative regulation of synaptic vesicle fusion to presynaptic active zone membrane", "down-regulation of synaptic vesicle fusion to presynaptic active zone membrane", "downregulation of synaptic vesicle fusion to presynaptic active zone membrane", "negative regulation of synaptic vesicle fusion to pre-synaptic active zone membrane"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. [GOC:mah]", "canonical_name": "down regulation of synaptic vesicle fusion to presynaptic active zone membrane"}
{"concept_id": "C1621536", "aliases": ["cytosolic proteasome regulatory particle, lid subcomplex location"], "types": ["T026"], "canonical_name": "cytosolic proteasome regulatory particle, lid subcomplex", "definition": "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1621537", "aliases": ["homologous chromosome orientation during meiosis"], "types": ["T043"], "canonical_name": "homologous chromosome orientation during meiosis I"}
{"concept_id": "C1621538", "aliases": ["neurotrophin-induced neuronal synaptic plasticity"], "types": ["T042"], "canonical_name": "regulation of neuronal synaptic plasticity in response to neurotrophin", "definition": "The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:mah, PMID:8703078]"}
{"concept_id": "C1621540", "aliases": [], "types": ["T026"], "canonical_name": "spindle pole centrosome", "definition": "A centrosome from which one pole of a mitotic or meiotic spindle is organized. [GOC:mah]"}
{"concept_id": "C1621541", "aliases": ["regulation of pyrexia"], "types": ["T040"], "canonical_name": "regulation of fever generation", "definition": "Any process that modulates the rate or extent of fever generation. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C1621546", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nutrient", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:mah]"}
{"concept_id": "C1621547", "aliases": ["up regulation of neurological process", "upregulation of neurological process", "positive regulation of neurophysiological process", "positive regulation of neurological system process", "up-regulation of neurological process", "positive regulation of neurological process"], "types": ["T040"], "canonical_name": "positive regulation of nervous system process", "definition": "Any process that activates or increases the frequency, rate or extent of a neurophysiological process. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1621549", "aliases": ["regulation of neurological process", "regulation of neurophysiological process", "regulation of neurological system process"], "types": ["T040"], "canonical_name": "regulation of nervous system process", "definition": "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1621550", "aliases": ["regulation of LPS-mediated signaling pathway", "regulation of lipopolysaccharide-mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of lipopolysaccharide-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. [GOC:mah]"}
{"concept_id": "C1621552", "aliases": ["G-beta/G-gamma complex", "G-protein beta/gamma-subunit complex location", "G-beta/G-gamma complex location"], "types": ["T026"], "canonical_name": "G-protein beta/gamma-subunit complex", "definition": "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange. [GOC:mah]"}
{"concept_id": "C1621553", "aliases": [], "types": ["T040"], "canonical_name": "regulation of heat dissipation", "definition": "Any process that modulates the rate or extent of heat dissipation. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1621554", "aliases": ["up regulation of heat dissipation", "upregulation of heat dissipation", "up-regulation of heat dissipation"], "types": ["T040"], "canonical_name": "positive regulation of heat dissipation", "definition": "Any process that activates or increases the rate or extent of heat dissipation. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1621555", "aliases": ["LPS-mediated signaling pathway", "lipopolysaccharide-mediated signalling pathway"], "types": ["T044"], "canonical_name": "lipopolysaccharide-mediated signaling pathway", "definition": "The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. [GOC:mah, GOC:signaling, PMID:15379975]"}
{"concept_id": "C1621556", "aliases": ["positive regulation of LPS-mediated signaling pathway", "up regulation of lipopolysaccharide-mediated signaling pathway", "positive regulation of lipopolysaccharide-mediated signalling pathway", "up-regulation of lipopolysaccharide-mediated signaling pathway", "upregulation of lipopolysaccharide-mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of lipopolysaccharide-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. [GOC:mah]"}
{"concept_id": "C1621558", "aliases": ["vitamin A binding"], "types": ["T044"], "canonical_name": "vitamin A binding"}
{"concept_id": "C1621559", "aliases": [], "types": ["T045"], "canonical_name": "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity"}
{"concept_id": "C1621560", "aliases": [], "types": ["T044"], "canonical_name": "ferric-hydroxamate porter activity"}
{"concept_id": "C1621561", "aliases": ["proton pump"], "types": ["T044"], "canonical_name": "proton pump activity"}
{"concept_id": "C1621562", "aliases": [], "types": ["T044"], "canonical_name": "alpha-2B adrenergic receptor binding", "definition": "Binding to an alpha-2B adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621564", "aliases": [], "types": ["T044"], "canonical_name": "IL-17E"}
{"concept_id": "C1621565", "aliases": [], "types": ["T044"], "canonical_name": "adenosine receptor ligand"}
{"concept_id": "C1621567", "aliases": [], "types": ["T044"], "canonical_name": "alpha-2C adrenergic receptor ligand"}
{"concept_id": "C1621568", "aliases": [], "types": ["T044"], "canonical_name": "A3 adenosine receptor ligand"}
{"concept_id": "C1621572", "aliases": ["TNF receptor activity, type II"], "types": ["T044"], "canonical_name": "tumor necrosis factor receptor activity, type II"}
{"concept_id": "C1621573", "aliases": [], "types": ["T044"], "canonical_name": "active transporter"}
{"concept_id": "C1621574", "aliases": [], "types": ["T044"], "canonical_name": "exchanger"}
{"concept_id": "C1621575", "aliases": ["calciol synthesis", "vitamin D3 synthesis", "cholecalciferol biosynthetic process", "calciol formation", "calciol biosynthesis", "vitamin D3 biosynthesis", "cholecalciferol biosynthesis", "vitamin D3 anabolism", "calciol anabolism", "calciol biosynthetic process", "vitamin D3 formation"], "types": ["T044"], "canonical_name": "vitamin D3 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of vitamin D3. [GOC:TermGenie, GOC:yaf, Unipathway:UPA00955]"}
{"concept_id": "C1621576", "aliases": ["hemoglobin hydrolysis"], "types": ["T044"], "canonical_name": "haemoglobin hydrolysis"}
{"concept_id": "C1621577", "aliases": [], "types": ["T043"], "canonical_name": "pole granule RNA localization"}
{"concept_id": "C1621578", "aliases": ["monocyte chemoattractant protein 1 receptor binding"], "types": ["T044"], "canonical_name": "CCR2 chemokine receptor binding", "definition": "Binding to a CCR2 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621579", "aliases": [], "types": ["T044"], "canonical_name": "bombesin receptor ligand"}
{"concept_id": "C1621580", "aliases": [], "types": ["T044"], "canonical_name": "adrenomedullin receptor binding", "definition": "Binding to an adrenomedullin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621581", "aliases": ["AT2 receptor binding"], "types": ["T044"], "canonical_name": "type 2 angiotensin receptor binding", "definition": "Binding to a type 2 angiotensin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621582", "aliases": [], "types": ["T044"], "canonical_name": "subtype 3 bombesin receptor ligand"}
{"concept_id": "C1621586", "aliases": [], "types": ["T044"], "canonical_name": "B2 bradykinin receptor binding", "definition": "Binding to a B2 bradykinin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621587", "aliases": [], "types": ["T044"], "canonical_name": "bradykinin receptor binding", "definition": "Binding to a bradykinin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621588", "aliases": [], "types": ["T044"], "canonical_name": "B1 bradykinin receptor ligand"}
{"concept_id": "C1621589", "aliases": [], "types": ["T044"], "canonical_name": "neuromedin B receptor binding", "definition": "Binding to a neuromedin B receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621590", "aliases": [], "types": ["T044"], "canonical_name": "calcitonin receptor binding", "definition": "Binding to a calcitonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621591", "aliases": [], "types": ["T044"], "canonical_name": "type 1 cannabinoid receptor ligand"}
{"concept_id": "C1621592", "aliases": [], "types": ["T026"], "canonical_name": "14S cohesin"}
{"concept_id": "C1621593", "aliases": [], "types": ["T044"], "canonical_name": "CCR5 chemokine receptor ligand"}
{"concept_id": "C1621594", "aliases": ["neurokinin-A receptor binding"], "types": ["T044"], "canonical_name": "substance K receptor binding", "definition": "Binding to a substance K receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621595", "aliases": ["pancreatic polypeptide receptor binding"], "types": ["T044"], "canonical_name": "type 4 neuropeptide Y receptor binding", "definition": "Binding to a type 4 neuropeptide Y receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621596", "aliases": ["prostanoid EP2 receptor binding"], "types": ["T044"], "canonical_name": "EP2 subtype prostaglandin E2 receptor binding", "definition": "Binding to an EP2 subtype prostaglandin E2 receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621597", "aliases": ["prostanoid EP3 receptor binding"], "types": ["T044"], "canonical_name": "EP3 subtype prostaglandin E2 receptor binding", "definition": "Binding to an EP3 subtype prostaglandin E2 receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621598", "aliases": [], "types": ["T044"], "canonical_name": "type 2 metabotropic GABA receptor ligand"}
{"concept_id": "C1621599", "aliases": [], "types": ["T044"], "canonical_name": "M1 muscarinic acetylcholine receptor binding"}
{"concept_id": "C1621600", "aliases": [], "types": ["T044"], "canonical_name": "muscarinic acetylcholine receptor ligand"}
{"concept_id": "C1621601", "aliases": [], "types": ["T044"], "canonical_name": "melatonin receptor ligand"}
{"concept_id": "C1621602", "aliases": [], "types": ["T044"], "canonical_name": "type 1 neuropeptide Y receptor binding", "definition": "Binding to a type 1 neuropeptide Y receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621603", "aliases": [], "types": ["T044"], "canonical_name": "type 5 neuropeptide Y receptor binding", "definition": "Binding to a type 5 neuropeptide Y receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621604", "aliases": [], "types": ["T044"], "canonical_name": "oxytocin receptor ligand"}
{"concept_id": "C1621605", "aliases": [], "types": ["T044"], "canonical_name": "neuromedin K receptor ligand"}
{"concept_id": "C1621606", "aliases": [], "types": ["T044"], "canonical_name": "mu-type opioid receptor binding", "definition": "Binding to a mu-type opioid receptor. [GOC:mah, GOC:nln, GOC:sl]"}
{"concept_id": "C1621607", "aliases": [], "types": ["T044"], "canonical_name": "pituitary adenylate cyclase-activating peptide receptor ligand"}
{"concept_id": "C1621608", "aliases": ["maintenance of wing hair orientation"], "types": ["T042"], "canonical_name": "maintenance of imaginal disc-derived wing hair orientation", "definition": "Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity. [GOC:mtg_sensu, PMID:15501220]"}
{"concept_id": "C1621610", "aliases": [], "types": ["T040"], "canonical_name": "dauer larval development", "definition": "The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. [GOC:ems, ISBN:087969307X]"}
{"concept_id": "C1621611", "aliases": [], "types": ["T044"], "canonical_name": "CCR9 chemokine receptor ligand"}
{"concept_id": "C1621612", "aliases": [], "types": ["T044"], "canonical_name": "neurokinin receptor binding", "definition": "Binding to a neurokinin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621613", "aliases": ["haptoglobin-hemoglobin complex location"], "types": ["T026"], "definition": "A protein complex formed by the stable binding of a haptoglobin to hemoglobin. [GOC:mah]", "canonical_name": "haptoglobin-hemoglobin complex"}
{"concept_id": "C1621614", "aliases": [], "types": ["T044"], "canonical_name": "nociceptin receptor ligand"}
{"concept_id": "C1621615", "aliases": ["telomere 3'-end processing"], "types": ["T045"], "canonical_name": "telomeric 3' overhang formation", "definition": "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans. [PMID:16096639]"}
{"concept_id": "C1621616", "aliases": [], "types": ["T044"], "canonical_name": "type 1 neurotensin receptor ligand"}
{"concept_id": "C1621617", "aliases": ["protection from NHEJ-mediated telomere fusion"], "types": ["T045"], "canonical_name": "protection from non-homologous end joining at telomere", "definition": "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse. [GOC:mah]"}
{"concept_id": "C1621618", "aliases": ["type 2 PACAP receptor binding"], "types": ["T044"], "canonical_name": "type 1 vasoactive intestinal polypeptide receptor binding", "definition": "Binding to a type 1 vasoactive intestinal polypeptide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621620", "aliases": [], "types": ["T026"], "canonical_name": "chromoplast envelope", "definition": "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. [GOC:pz]"}
{"concept_id": "C1621621", "aliases": [], "types": ["T044"], "canonical_name": "secretin receptor ligand"}
{"concept_id": "C1621622", "aliases": [], "types": ["T044"], "canonical_name": "type 1 member 1 taste receptor ligand"}
{"concept_id": "C1621623", "aliases": [], "types": ["T044"], "canonical_name": "thromboxane A2 receptor ligand"}
{"concept_id": "C1621624", "aliases": [], "types": ["T044"], "canonical_name": "type 2 proteinase activated receptor ligand"}
{"concept_id": "C1621625", "aliases": ["oocyte axis determination, oocyte nucleus anchoring", "oocyte axis determination, maintenance of oocyte nucleus position", "oocyte nucleus anchoring during oocyte axis determination", "oocyte axis determination, maintenance of oocyte nucleus localization", "maintenance of oocyte nucleus position during oocyte axis determination"], "types": ["T043"], "canonical_name": "maintenance of oocyte nucleus localization during oocyte axis determination"}
{"concept_id": "C1621626", "aliases": [], "types": ["T044"], "canonical_name": "CCR11 chemokine receptor ligand"}
{"concept_id": "C1621627", "aliases": ["LPA2 receptor binding"], "types": ["T044"], "canonical_name": "Edg-4 lysophosphatidic acid receptor binding", "definition": "Binding to an Edg-4 lysophosphatidic acid receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621628", "aliases": ["N-formyl peptide receptor binding"], "types": ["T044"], "canonical_name": "fMet-Leu-Phe receptor binding", "definition": "Binding to a fMet-Leu-Phe receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621629", "aliases": [], "types": ["T044"], "canonical_name": "Edg-6 sphingosine 1-phosphate receptor ligand"}
{"concept_id": "C1621630", "aliases": [], "types": ["T044"], "canonical_name": "prostacyclin receptor ligand"}
{"concept_id": "C1621631", "aliases": [], "types": ["T044"], "canonical_name": "type 2 metabotropic glutamate receptor binding", "definition": "Binding to a type 2 metabotropic glutamate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621632", "aliases": [], "types": ["T044"], "canonical_name": "type 7 metabotropic glutamate receptor binding", "definition": "Binding to a type 7 metabotropic glutamate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621635", "aliases": ["protein amino acid phosphate-linked glycosylation via serine"], "types": ["T044"], "canonical_name": "protein phosphate-linked glycosylation via serine", "definition": "The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues. [GOC:mah]"}
{"concept_id": "C1621636", "aliases": ["TOR signal transduction", "target of rapamycin signaling pathway", "target of rapamycin signalling pathway", "TOR signaling cascade", "TOR signaling pathway", "TOR signalling pathway"], "types": ["T044"], "canonical_name": "TOR signaling", "definition": "The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. [PMID:12372295]"}
{"concept_id": "C1621637", "aliases": [], "types": ["T026"], "canonical_name": "proteinoplast", "definition": "A leucoplast in which protein is stored. [GOC:pz]"}
{"concept_id": "C1621638", "aliases": ["IL-28 receptor complex location", "IL-28 receptor complex", "interleukin-28 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-28 receptor complex", "definition": "A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1). [GOC:rph]"}
{"concept_id": "C1621639", "aliases": [], "types": ["T044"], "canonical_name": "H4 histamine receptor binding", "definition": "Binding to a H4 histamine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621642", "aliases": [], "types": ["T044"], "canonical_name": "endothelial differentiation G-protein coupled receptor ligand"}
{"concept_id": "C1621643", "aliases": ["1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity", "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "1,4-alpha-glucan 6-alpha-glucosyltransferase activity", "definition": "Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan. [EC:2.4.1.24]"}
{"concept_id": "C1621644", "aliases": ["i-AAA complex location"], "types": ["T026"], "canonical_name": "i-AAA complex", "definition": "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases. [PMID:16247555, PMID:16267274]"}
{"concept_id": "C1621645", "aliases": [], "types": ["T044"], "canonical_name": "P2Y2 nucleotide receptor ligand"}
{"concept_id": "C1621646", "aliases": [], "types": ["T044"], "canonical_name": "type 8 metabotropic glutamate receptor ligand"}
{"concept_id": "C1621647", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxal transporter activity"}
{"concept_id": "C1621648", "aliases": ["regulation of glucocorticoid metabolism"], "types": ["T044"], "canonical_name": "regulation of glucocorticoid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. [GOC:mah]"}
{"concept_id": "C1621649", "aliases": [], "types": ["T044"], "canonical_name": "T-enzyme"}
{"concept_id": "C1621651", "aliases": ["upregulation of glucocorticoid metabolic process", "up-regulation of glucocorticoid metabolic process", "positive regulation of glucocorticoid metabolism", "up regulation of glucocorticoid metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of glucocorticoid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. [GOC:mah]"}
{"concept_id": "C1621654", "aliases": [], "types": ["T044"], "canonical_name": "type 4 melanocortin receptor binding", "definition": "Binding to a type 4 melanocortin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621655", "aliases": [], "types": ["T026"], "canonical_name": "mating-type region heterochromatin", "definition": "Heterochromatic regions of the chromosome found at silenced mating-type loci. [GOC:mah]"}
{"concept_id": "C1621656", "aliases": [], "types": ["T044"], "canonical_name": "type 3 galanin receptor ligand"}
{"concept_id": "C1621657", "aliases": [], "types": ["T044"], "canonical_name": "type 1 melanin-concentrating hormone receptor binding", "definition": "Binding to a type 1 melanin-concentrating hormone receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621658", "aliases": ["downregulation of dephosphorylation", "down regulation of dephosphorylation", "down-regulation of dephosphorylation"], "types": ["T043"], "canonical_name": "negative regulation of dephosphorylation", "definition": "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. [GOC:bf]"}
{"concept_id": "C1621659", "aliases": [], "types": ["T043"], "canonical_name": "wound healing, spreading of epidermal cells", "definition": "The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. [GOC:bf, PMID:15269788]"}
{"concept_id": "C1621660", "aliases": ["G-protein coupled serotonin receptor binding", "metabotropic 5-hydroxytryptamine receptor binding", "metabotropic serotonin receptor binding"], "types": ["T044"], "canonical_name": "G protein-coupled serotonin receptor binding", "definition": "Binding to a metabotropic serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621661", "aliases": [], "types": ["T044"], "canonical_name": "P2Y9 nucleotide receptor ligand"}
{"concept_id": "C1621662", "aliases": [], "types": ["T044"], "canonical_name": "lutropin-choriogonadotropic hormone receptor binding", "definition": "Binding to a lutropin-choriogonadotropic hormone receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621663", "aliases": [], "types": ["T044"], "canonical_name": "type 3 melanocortin receptor binding", "definition": "Binding to a type 3 melanocortin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621664", "aliases": ["ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity", "Ins(1,3,4)P3 6-kinase activity", "ins(1,3,4)P(3) 6-kinase activity", "inositol 1,3,4-trisphosphate 6-kinase activity"], "types": ["T044"], "canonical_name": "inositol-1,3,4-trisphosphate 6-kinase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+). [EC:2.7.1.134]"}
{"concept_id": "C1621665", "aliases": ["up regulation of dephosphorylation", "up-regulation of dephosphorylation", "upregulation of dephosphorylation"], "types": ["T043"], "canonical_name": "positive regulation of dephosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. [GOC:bf]"}
{"concept_id": "C1621667", "aliases": ["5-hydroxytryptamine 2A receptor binding"], "types": ["T044"], "canonical_name": "type 2A serotonin receptor binding", "definition": "Binding to a type 2A serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1621668", "aliases": ["negative regulation of protein amino acid dephosphorylation", "down regulation of protein amino acid dephosphorylation", "downregulation of protein amino acid dephosphorylation", "down-regulation of protein amino acid dephosphorylation"], "types": ["T044"], "canonical_name": "negative regulation of protein dephosphorylation", "definition": "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein. [GOC:bf]"}
{"concept_id": "C1621669", "aliases": ["non-sensory hair organization and biogenesis"], "types": ["T043"], "canonical_name": "non-sensory hair organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis. [GOC:mtg_sensu, PMID:11064425]"}
{"concept_id": "C1621670", "aliases": ["regulation of protein amino acid dephosphorylation"], "types": ["T044"], "canonical_name": "regulation of protein dephosphorylation", "definition": "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein. [GOC:bf]"}
{"concept_id": "C1621671", "aliases": [], "types": ["T045"], "canonical_name": "5'-3' exodeoxyribonuclease activity", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. [ISBN:0198547684]"}
{"concept_id": "C1621672", "aliases": ["naphthoquinone metabolism"], "types": ["T044"], "canonical_name": "naphthoquinone metabolism"}
{"concept_id": "C1621673", "aliases": [], "types": ["T044"], "canonical_name": "major histocompatibility complex class II ligand"}
{"concept_id": "C1621713", "aliases": ["protein amino acid N-linked glycosylation via arginine"], "types": ["T044"], "canonical_name": "protein N-linked glycosylation via arginine", "definition": "The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine. [RESID:AA0327]"}
{"concept_id": "C1621717", "aliases": ["down regulation of mesodermal cell fate specification", "down-regulation of mesodermal cell fate specification", "downregulation of mesodermal cell fate specification", "suppression of mesodermal cell fate"], "types": ["T043"], "canonical_name": "negative regulation of mesodermal cell fate specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification. [GOC:go_curators]"}
{"concept_id": "C1621723", "aliases": ["up regulation of eosinophil degranulation", "upregulation of eosinophil degranulation", "up-regulation of eosinophil degranulation", "positive regulation of eosinophil granule exocytosis"], "types": ["T043"], "canonical_name": "positive regulation of eosinophil degranulation", "definition": "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation. [ISBN:0781735149]"}
{"concept_id": "C1621749", "aliases": ["5HT uptake", "serotonin import", "serotonin uptake", "5-hydroxytryptamine uptake"], "types": ["T044"], "definition": "The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. [GOC:ai]", "canonical_name": "5-HT uptake"}
{"concept_id": "C1621750", "aliases": [], "types": ["T044"], "canonical_name": "taxol biosynthesis"}
{"concept_id": "C1621758", "aliases": [], "types": ["T040"], "canonical_name": "active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism involved in symbiotic interaction"}
{"concept_id": "C1621762", "aliases": ["response to exogenous double-stranded RNA"], "types": ["T040"], "canonical_name": "response to exogenous dsRNA", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. [GOC:go_curators]"}
{"concept_id": "C1621765", "aliases": ["pigment metabolic process during developmental pigmentation"], "types": ["T043"], "canonical_name": "pigment metabolism during developmental pigmentation"}
{"concept_id": "C1621767", "aliases": ["up regulation of leukocyte degranulation", "up-regulation of leukocyte degranulation", "positive regulation of immune cell degranulation", "positive regulation of leucocyte degranulation", "upregulation of leukocyte degranulation"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte degranulation", "definition": "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1621768", "aliases": ["positive regulation of memory T-cell differentiation", "positive regulation of memory T-lymphocyte differentiation", "upregulation of memory T cell differentiation", "positive regulation of memory T lymphocyte differentiation", "up-regulation of memory T cell differentiation", "up regulation of memory T cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of memory T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation. [ISBN:0781735149]"}
{"concept_id": "C1621771", "aliases": ["regulation of CD8-positive, alpha beta T-cell differentiation", "regulation of CD8-positive T-cell differentiation", "regulation of CD8-positive T-lymphocyte differentiation", "regulation of CD8-positive, alpha beta T-lymphocyte differentiation", "regulation of CD8-positive T lymphocyte differentiation", "regulation of CD8-positive, alpha beta T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of CD8-positive, alpha-beta T cell differentiation", "definition": "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1621773", "aliases": [], "types": ["T043"], "canonical_name": "beta selection", "definition": "The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell. [ISBN:0781735149, PMID:12220932]"}
{"concept_id": "C1621774", "aliases": ["response to double-stranded RNA"], "types": ["T043"], "canonical_name": "response to dsRNA", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. [GOC:jl]"}
{"concept_id": "C1621775", "aliases": ["positive T-lymphocyte selection", "positive T-cell selection", "positive T lymphocyte selection"], "types": ["T043"], "canonical_name": "positive T cell selection", "definition": "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. [ISBN:0781735149, PMID:12414722]"}
{"concept_id": "C1621778", "aliases": ["nucleate red blood cell differentiation", "nucleate RBC differentiation"], "types": ["T043"], "canonical_name": "nucleate erythrocyte differentiation", "definition": "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. [GOC:jl]"}
{"concept_id": "C1621779", "aliases": ["immune cell degranulation", "immune cell granule exocytosis", "leukocyte granule exocytosis", "leucocyte degranulation"], "types": ["T043"], "canonical_name": "leukocyte degranulation", "definition": "The regulated exocytosis of secretory granules by a leukocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1621781", "aliases": ["memory T lymphocyte differentiation", "memory T-lymphocyte differentiation", "memory T-cell differentiation"], "types": ["T043"], "canonical_name": "memory T cell differentiation", "definition": "The process in which a newly activated T cell acquires specialized features of a memory T cell. [ISBN:0781735149]"}
{"concept_id": "C1621786", "aliases": ["2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. [GOC:kd, PMID:9045837]", "canonical_name": "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity"}
{"concept_id": "C1621787", "aliases": [], "types": ["T044"], "canonical_name": "CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity", "definition": "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol. [GOC:jl]"}
{"concept_id": "C1621788", "aliases": ["down-regulation of DNA binding", "down regulation of DNA binding", "downregulation of DNA binding"], "types": ["T045"], "canonical_name": "negative regulation of DNA binding", "definition": "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C1621789", "aliases": [], "types": ["T044"], "canonical_name": "proteoglycan binding", "definition": "Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [ISBN:0198506732]"}
{"concept_id": "C1621790", "aliases": [], "types": ["T044"], "canonical_name": "heparan sulfate proteoglycan binding", "definition": "Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. [ISBN:0198506732]"}
{"concept_id": "C1621795", "aliases": [], "types": ["T044"], "canonical_name": "aflatoxin B metabolic process"}
{"concept_id": "C1621799", "aliases": ["stimulation of MAPK cascade", "stimulation of MAPKKK cascade", "positive regulation of mitogen activated protein kinase kinase kinase cascade", "up-regulation of MAPKKK cascade", "positive regulation of MAP kinase cascade", "upregulation of MAPKKK cascade", "positive regulation of MAP kinase kinase kinase cascade", "up regulation of MAPKKK cascade", "up-regulation of MAPK cascade", "upregulation of MAPK cascade", "positive regulation of mitogen-activated protein kinase cascade", "positive regulation of mitogen-activated protein kinase kinase kinase cascade", "positive regulation of MAPKKK cascade"], "types": ["T044"], "canonical_name": "positive regulation of MAPK cascade", "definition": "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]"}
{"concept_id": "C1621804", "aliases": [], "types": ["T042"], "canonical_name": "tongue development", "definition": "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. [GOC:jl, UBERON:0001723]"}
{"concept_id": "C1621805", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin. [PMID:1655423]", "canonical_name": "cytochrome f"}
{"concept_id": "C1621807", "aliases": ["host cell shutoff"], "types": ["T046"], "canonical_name": "host cell protein synthesis shutoff"}
{"concept_id": "C1621812", "aliases": [], "types": ["T043"], "definition": "The phase of cell nucleus division following PROMETAPHASE, in which the CHROMOSOMES line up across the equatorial plane of the SPINDLE APPARATUS prior to separation.", "canonical_name": "metaphase"}
{"concept_id": "C1621823", "aliases": ["SMC complex", "SMC complex location"], "types": ["T026"], "canonical_name": "SMC complex"}
{"concept_id": "C1621827", "aliases": ["postsynaptic membrane organisation", "post-synaptic membrane organization"], "types": ["T043"], "canonical_name": "postsynaptic membrane organization", "definition": "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). [GOC:dph, GOC:pr]"}
{"concept_id": "C1621828", "aliases": ["positive regulation of cytokine mediated signaling pathway", "up-regulation of cytokine mediated signaling pathway", "positive regulation of cytokine and chemokine mediated signaling pathway", "positive regulation of cytokine mediated signalling pathway", "upregulation of cytokine mediated signaling pathway", "up regulation of cytokine mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of cytokine-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway. [GOC:hjd]"}
{"concept_id": "C1621829", "aliases": [], "types": ["T040"], "canonical_name": "response to amphetamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:dph, GOC:ef]"}
{"concept_id": "C1621830", "aliases": [], "types": ["T040"], "canonical_name": "renal blood volume control of blood pressure"}
{"concept_id": "C1621832", "aliases": ["stereotaxis", "taxis in response to touch stimulus"], "types": ["T040"], "definition": "The directed movement of an animal in response to touch. [GOC:dph]", "canonical_name": "thigmotaxis"}
{"concept_id": "C1621833", "aliases": [], "types": ["T026"], "canonical_name": "regulation of cell-matrix adhesion", "definition": "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. [GOC:hjd]"}
{"concept_id": "C1621835", "aliases": ["negative regulation of MAC formation", "negative regulation of membrane attack complex formation", "negative regulation of MAC assembly", "negative regulation of membrane attack complex assembly", "downregulation of activation of membrane attack complex", "negative regulation of activation of MAC", "down-regulation of activation of membrane attack complex", "down regulation of activation of membrane attack complex"], "types": ["T043"], "canonical_name": "negative regulation of activation of membrane attack complex", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. [GOC:hjd]"}
{"concept_id": "C1621836", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of heart contraction rate by epinephrine-norepinephrine"}
{"concept_id": "C1621837", "aliases": [], "types": ["T044"], "canonical_name": "protease binding", "definition": "Binding to a protease or a peptidase. [GOC:hjd]"}
{"concept_id": "C1621838", "aliases": ["renin release into blood stream"], "types": ["T043"], "canonical_name": "renin secretion into blood stream", "definition": "The regulated release of renin into the blood stream by juxtoglomerular cells. [ISBN:0721643949]"}
{"concept_id": "C1621841", "aliases": ["regulation of blood angiotensin level"], "types": ["T040"], "canonical_name": "regulation of angiotensin levels in blood", "definition": "The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation. [GOC:rl, PMID:21951628, Wikipedia:Angiotensin]"}
{"concept_id": "C1621842", "aliases": ["excitation of vasomotor center by chemoreceptor signalling"], "types": ["T040"], "canonical_name": "excitation of vasomotor center by chemoreceptor signaling", "definition": "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure. [GOC:dph]"}
{"concept_id": "C1621843", "aliases": [], "types": ["T039"], "canonical_name": "baroreceptor detection of arterial stretch", "definition": "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal. [GOC:mtg_cardio, ISBN:0721643949]"}
{"concept_id": "C1621844", "aliases": ["up regulation of heart contraction rate in baroreceptor response to decreased blood pressure", "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure", "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure", "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure", "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure", "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure", "activation of heart contraction rate in baroreceptor response to decreased blood pressure", "positive control of heart contraction rate in baroreceptor response to decreased blood pressure"], "types": ["T039"], "canonical_name": "positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure. [ISBN:0721643949]"}
{"concept_id": "C1621846", "aliases": [], "types": ["T044"], "canonical_name": "immunoglobulin"}
{"concept_id": "C1621850", "aliases": ["regulation of sodium transport", "regulation of Na+ transport"], "types": ["T043"], "canonical_name": "regulation of sodium ion transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph]"}
{"concept_id": "C1621852", "aliases": [], "types": ["T044"], "canonical_name": "beta-fructosidase activity"}
{"concept_id": "C1621855", "aliases": ["PTS1 receptor", "PEX5"], "types": ["T044"], "canonical_name": "peroxisome targeting signal-1 receptor"}
{"concept_id": "C1621859", "aliases": [], "types": ["T045"], "canonical_name": "plasmid binding", "definition": "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms. [ISBN:0198506732]"}
{"concept_id": "C1621861", "aliases": ["G-protein coupled receptor internalization"], "types": ["T043"], "canonical_name": "G protein-coupled receptor internalization", "definition": "The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle. [PMID:8396717]"}
{"concept_id": "C1621882", "aliases": ["CstF complex location"], "types": ["T026"], "canonical_name": "CstF complex"}
{"concept_id": "C1621883", "aliases": ["CPSF complex location"], "types": ["T026"], "canonical_name": "CPSF complex"}
{"concept_id": "C1621884", "aliases": [], "types": ["T026"], "canonical_name": "peripheral cytoplasm"}
{"concept_id": "C1621892", "aliases": ["ER translocation"], "types": ["T043"], "canonical_name": "ER translocation"}
{"concept_id": "C1621894", "aliases": [], "types": ["T045"], "canonical_name": "intrastrand cross-link repair"}
{"concept_id": "C1621896", "aliases": ["adenylate cyclase activator"], "types": ["T044"], "canonical_name": "adenylate cyclase activator"}
{"concept_id": "C1621897", "aliases": [], "types": ["T042"], "canonical_name": "ectodermal gut development"}
{"concept_id": "C1621898", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme Q6 biosynthesis"}
{"concept_id": "C1621899", "aliases": ["oocyte nuclear migration during oocyte axis determination", "oocyte axis determination, oocyte nuclear migration", "oocyte axis determination, oocyte nucleus migration", "oocyte nucleus migration during oocyte axis determination"], "types": ["T043"], "canonical_name": "oocyte nucleus migration involved in oocyte dorsal/ventral axis specification", "definition": "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster. [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C1621901", "aliases": ["eye pigment granule organisation", "eye pigment granule organization and biogenesis"], "types": ["T043"], "canonical_name": "eye pigment granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye. [PMID:9303295]"}
{"concept_id": "C1621907", "aliases": [], "types": ["T044"], "canonical_name": "DNA methylase"}
{"concept_id": "C1621908", "aliases": [], "types": ["T045"], "canonical_name": "chromosome inactivation"}
{"concept_id": "C1621910", "aliases": ["desiccation tolerance"], "types": ["T043"], "canonical_name": "response to desiccation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. [GOC:jl]"}
{"concept_id": "C1621911", "aliases": [], "types": ["T026"], "canonical_name": "50S ribosomal subunit"}
{"concept_id": "C1621914", "aliases": ["allantoin catabolic process via ureidoglycolate", "allantoin catabolism via ureidoglycolate"], "types": ["T044"], "canonical_name": "allantoin assimilation pathway", "definition": "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP. [MetaCyc:PWY0-41]"}
{"concept_id": "C1621915", "aliases": ["4-aminobutyrate biosynthesis", "gamma-aminobutyric acid synthesis", "4-aminobutanoate biosynthesis", "gamma-aminobutyric acid formation", "GABA biosynthesis", "4-aminobutanoate biosynthetic process", "gamma-aminobutyric acid anabolism", "GABA biosynthetic process", "4-aminobutyrate biosynthetic process", "gamma-aminobutyric acid biosynthesis"], "types": ["T044"], "canonical_name": "gamma-aminobutyric acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [GOC:ai]"}
{"concept_id": "C1621919", "aliases": ["endomembrane system organisation", "endomembrane organization"], "types": ["T043"], "canonical_name": "endomembrane system organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. [GOC:mah, GOC:sm]"}
{"concept_id": "C1621921", "aliases": [], "types": ["T040"], "canonical_name": "fruit development", "definition": "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant. [GOC:sm]"}
{"concept_id": "C1621922", "aliases": [], "types": ["T040"], "canonical_name": "somatic embryogenesis", "definition": "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes. [GOC:sm, PMID:9611173]"}
{"concept_id": "C1621925", "aliases": [], "types": ["T044"], "canonical_name": "amino acid ABC transporter"}
{"concept_id": "C1621926", "aliases": [], "types": ["T044"], "canonical_name": "polar-amino acid ABC transporter"}
{"concept_id": "C1621927", "aliases": [], "types": ["T044"], "canonical_name": "polyamine ABC transporter"}
{"concept_id": "C1621928", "aliases": [], "types": ["T044"], "canonical_name": "oligopeptide ABC transporter"}
{"concept_id": "C1621930", "aliases": ["molybdate ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type molybdate transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in). [RHEA:22020]"}
{"concept_id": "C1621932", "aliases": [], "types": ["T043"], "canonical_name": "response to low fluence blue light"}
{"concept_id": "C1621933", "aliases": ["plastoquinone formation", "plastoquinone anabolism", "plastoquinone biosynthesis", "plastoquinone synthesis"], "types": ["T044"], "canonical_name": "plastoquinone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast. [GOC:sm]"}
{"concept_id": "C1621935", "aliases": ["GABA transport", "4-aminobutanoate transport", "4-aminobutyrate transport"], "types": ["T043"], "canonical_name": "gamma-aminobutyric acid transport", "definition": "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C1621936", "aliases": ["tapetal cell fate specification"], "types": ["T043"], "canonical_name": "anther wall tapetum cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:mg]"}
{"concept_id": "C1621937", "aliases": [], "types": ["T040"], "canonical_name": "inflorescence development", "definition": "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure. [GOC:tb]"}
{"concept_id": "C1621939", "aliases": [], "types": ["T044"], "canonical_name": "delta(6)-desaturase activity"}
{"concept_id": "C1621941", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid deamination, from amino carbon", "definition": "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol. [RESID:AA0127, RESID:AA0128, RESID:AA0129]"}
{"concept_id": "C1621946", "aliases": ["protein amino acid S-linked glycosylation via cysteine"], "types": ["T044"], "canonical_name": "protein S-linked glycosylation via cysteine", "definition": "The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine. [RESID:AA0152]"}
{"concept_id": "C1621947", "aliases": ["protein amino acid C-linked glycosylation via tryptophan"], "types": ["T044"], "canonical_name": "protein C-linked glycosylation via tryptophan", "definition": "The glycosylation of a carbon atom of a peptidyl-tryptophan residue. [GOC:ai]"}
{"concept_id": "C1621948", "aliases": ["alpha-glucosidase II complex location"], "types": ["T026"], "canonical_name": "alpha-glucosidase II complex"}
{"concept_id": "C1621950", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase methyltransferase activity"}
{"concept_id": "C1621951", "aliases": ["D-lactate synthesis from methylglyoxal via (R)-lactaldehyde", "D-lactate formation from methylglyoxal via (R)-lactaldehyde", "D-lactate anabolism from methylglyoxal via (R)-lactaldehyde"], "types": ["T044"], "canonical_name": "D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde", "definition": "The chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde. [GOC:dph, GOC:go_curators, MetaCyc:MGLDLCTANA-PWY]"}
{"concept_id": "C1621957", "aliases": ["glycine betaine synthesis from glycine", "glycine betaine anabolism from glycine", "N-trimethylglycine biosynthesis from glycine", "glycine betaine formation from glycine", "N-trimethylglycine biosynthetic process from glycine"], "types": ["T044"], "canonical_name": "glycine betaine biosynthetic process from glycine", "definition": "The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine. [GOC:go_curators]"}
{"concept_id": "C1621963", "aliases": ["acetyl-CoA catabolism to 2-ketoglutarate", "acetyl-CoA catabolic process to 2-ketoglutarate", "acetyl-CoA catabolism to alpha-ketoglutarate", "acetyl-CoA catabolism to 2-oxoglutarate", "acetyl-CoA catabolic process to 2-oxoglutarate", "acetyl-CoA catabolic process to alpha-oxoglutarate", "acetyl-CoA catabolism to alpha-oxoglutarate", "acetyl-CoA catabolic process to alpha-ketoglutarate"], "types": ["T044"], "canonical_name": "acetyl-CoA assimilation pathway", "definition": "The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell. [MetaCyc:P22-PWY]"}
{"concept_id": "C1621965", "aliases": ["Moco metabolism", "molybdopterin cofactor metabolism", "Moco metabolic process"], "types": ["T044"], "canonical_name": "molybdopterin cofactor metabolic process", "definition": "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. [ISSN:09498257]"}
{"concept_id": "C1621968", "aliases": [], "types": ["T043"], "definition": "The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.", "canonical_name": "cell movement"}
{"concept_id": "C1621969", "aliases": [], "types": ["T044"], "canonical_name": "protein-protein adaptor"}
{"concept_id": "C1621970", "aliases": ["oocyte localisation involved in germarium-derived egg chamber formation", "oocyte localization during oogenesis", "oogenesis, oocyte localization", "establishment and maintenance of oocyte localization in egg chamber", "establishment and maintenance of oocyte position during oogenesis", "oogenesis, establishment and maintenance of oocyte localization"], "types": ["T038"], "canonical_name": "oocyte localization involved in germarium-derived egg chamber formation", "definition": "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. [GOC:mtg_sensu, PMID:10449356]"}
{"concept_id": "C1621972", "aliases": ["embryonic eye development"], "types": ["T042"], "canonical_name": "embryonic camera-type eye development", "definition": "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1621975", "aliases": [], "types": ["T026"], "canonical_name": "organelle membrane", "definition": "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. [GOC:dos, GOC:mah]"}
{"concept_id": "C1621976", "aliases": ["platelet alpha-granule"], "types": ["T026"], "canonical_name": "platelet alpha granule", "definition": "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). [PMID:8467233]"}
{"concept_id": "C1621977", "aliases": [], "types": ["T026"], "canonical_name": "platelet dense tubular network membrane", "definition": "The lipid bilayer surrounding the platelet dense tubular network. [GOC:mah, PMID:1322202]"}
{"concept_id": "C1621978", "aliases": [], "types": ["T042"], "canonical_name": "neurite regeneration"}
{"concept_id": "C1621979", "aliases": ["regulation of microtubule disassembly"], "types": ["T043"], "canonical_name": "regulation of microtubule depolymerization", "definition": "Any process that modulates the frequency, rate or extent of microtubule depolymerization. [GOC:mah]"}
{"concept_id": "C1621980", "aliases": [], "types": ["T042"], "canonical_name": "axon regeneration", "definition": "The regrowth of axons following their loss or damage. [GOC:dgh, GOC:dph, GOC:tb]"}
{"concept_id": "C1621981", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microtubule polymerization or depolymerization", "definition": "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. [GOC:mah]"}
{"concept_id": "C1621982", "aliases": ["up regulation of microtubule depolymerization", "positive regulation of microtubule disassembly", "upregulation of microtubule depolymerization", "microtubule destabilization", "up-regulation of microtubule depolymerization"], "types": ["T043"], "canonical_name": "positive regulation of microtubule depolymerization", "definition": "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. [GOC:mah]"}
{"concept_id": "C1621984", "aliases": ["sister kinetochore biorientation", "chromosome biorientation"], "types": ["T043"], "canonical_name": "sister chromatid biorientation", "definition": "The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. [PMID:15309047]"}
{"concept_id": "C1621986", "aliases": [], "types": ["T042"], "canonical_name": "regulation of axon diameter", "definition": "Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1621987", "aliases": ["down-regulation of conjugation with cellular fusion", "down regulation of conjugation with cellular fusion", "downregulation of conjugation with cellular fusion"], "types": ["T043"], "canonical_name": "negative regulation of conjugation with cellular fusion", "definition": "Any process that decreases the rate or frequency of conjugation with cellular fusion. [GOC:mah]"}
{"concept_id": "C1621988", "aliases": ["up regulation of conjugation with cellular fusion", "upregulation of conjugation with cellular fusion", "up-regulation of conjugation with cellular fusion"], "types": ["T043"], "canonical_name": "positive regulation of conjugation with cellular fusion", "definition": "Any process that increases the rate or frequency of conjugation with cellular fusion. [GOC:mah]"}
{"concept_id": "C1621989", "aliases": ["DIF-1 metabolic process", "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism", "DIF-1 metabolism"], "types": ["T044"], "canonical_name": "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process", "definition": "The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells. [GOC:mah, PMID:10706822]"}
{"concept_id": "C1621990", "aliases": ["stalk cell differentiation"], "types": ["T043"], "canonical_name": "sorocarp stalk cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum. [GOC:mah, GOC:mtg_sensu, ISBN:0521583640, PMID:4338436]"}
{"concept_id": "C1621992", "aliases": [], "types": ["T044"], "canonical_name": "chrysobactin biosynthetic process, peptide formation"}
{"concept_id": "C1621994", "aliases": ["slug development during fruiting body development", "pseudoplasmodium biosynthesis", "pseudoplasmodium formation"], "types": ["T040"], "canonical_name": "slug development involved in sorocarp development", "definition": "The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development. [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]"}
{"concept_id": "C1621995", "aliases": ["spore wall", "spore coat"], "types": ["T026"], "canonical_name": "spore wall", "definition": "The specialized envelope lying outside the cell membrane of a spore. [GOC:mah, GOC:pg]"}
{"concept_id": "C1621996", "aliases": ["pullulan 4-D-glucanohydrolase (panose-forming)", "pullulanase II activity"], "types": ["T044"], "canonical_name": "neopullulanase activity", "definition": "Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose). [EC:3.2.1.135, GOC:mlg]"}
{"concept_id": "C1622000", "aliases": ["posttranslational protein targeting to membrane, translocation", "posttranslational protein membrane targeting, translocation", "protein translocation during posttranslational protein targeting to membrane"], "types": ["T043"], "canonical_name": "post-translational protein targeting to membrane, translocation", "definition": "The process in which a protein translocates through the ER membrane posttranslationally. [PMID:12518317, PMID:8707814]"}
{"concept_id": "C1622001", "aliases": ["ferricrocin metabolism"], "types": ["T044"], "canonical_name": "ferricrocin metabolic process", "definition": "The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3. [GOC:mah, PMID:12828635]"}
{"concept_id": "C1622002", "aliases": [], "types": ["T044"], "canonical_name": "phosphopantetheine binding", "definition": "Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). [GOC:mah, GOC:vw]"}
{"concept_id": "C1622003", "aliases": ["BTB domain", "POZ domain binding"], "types": ["T044"], "definition": "Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors. [PMID:7958847]", "canonical_name": "broad-complex, tramtrack, and bric-a-brac domain binding"}
{"concept_id": "C1622004", "aliases": ["arabinan metabolism"], "types": ["T044"], "canonical_name": "arabinan metabolic process", "definition": "The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues. [GOC:mlg, ISBN:0198506732]"}
{"concept_id": "C1622005", "aliases": ["endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity", "beta-1,4-xylanase activity", "1,4-beta-xylan xylanohydrolase activity", "endo-beta-1,4-xylanase activity", "1,4-beta-D-xylan xylanohydrolase activity", "endo-1,4-xylanase activity", "beta-D-xylanase activity", "endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity", "beta-1,4-xylan xylanohydrolase activity", "endo-1,4-beta-D-xylanase activity", "beta-xylanase activity"], "types": ["T044"], "canonical_name": "endo-1,4-beta-xylanase activity", "definition": "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. [EC:3.2.1.8]"}
{"concept_id": "C1622007", "aliases": ["intrinsic to internal side of outer membrane", "intrinsic to internal leaflet of cell outer membrane", "intrinsic to internal side of cell outer membrane"], "types": ["T026"], "canonical_name": "intrinsic component of periplasmic side of cell outer membrane", "definition": "The component of the cell outer membrane consisting of the gene products that that penetrate the periplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor. [GOC:dos, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622009", "aliases": ["intrinsic to membrane"], "types": ["T026"], "canonical_name": "intrinsic component of membrane", "definition": "The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. [GOC:mah]"}
{"concept_id": "C1622010", "aliases": ["anchored to membrane"], "types": ["T026"], "canonical_name": "anchored component of membrane", "definition": "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622011", "aliases": ["intrinsic to internal leaflet of plasma membrane", "intrinsic to internal side of plasma membrane"], "types": ["T026"], "canonical_name": "intrinsic component of the cytoplasmic side of the plasma membrane", "definition": "The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622012", "aliases": [], "types": ["T044"], "canonical_name": "denatured protein binding", "definition": "Binding to a denatured protein. [GOC:mlg]"}
{"concept_id": "C1622013", "aliases": ["extrinsic to external side of outer membrane", "extrinsic to external side of cell outer membrane", "extrinsic to external leaflet of cell outer membrane"], "types": ["T026"], "canonical_name": "extrinsic component of external side of cell outer membrane", "definition": "The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622014", "aliases": [], "types": ["T044"], "canonical_name": "hexitol dehydrogenase activity", "definition": "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor. [GOC:mah]"}
{"concept_id": "C1622015", "aliases": [], "types": ["T043"], "canonical_name": "ascospore-type prospore-specific spindle pole body modification"}
{"concept_id": "C1622016", "aliases": ["regulation of cellular metabolism"], "types": ["T040"], "canonical_name": "regulation of cellular metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. [GOC:mah]"}
{"concept_id": "C1622017", "aliases": [], "types": ["T026"], "canonical_name": "leading edge membrane", "definition": "The portion of the plasma membrane surrounding the leading edge of a motile cell. [GOC:mah]"}
{"concept_id": "C1622019", "aliases": ["regulation of pseudopodium formation"], "types": ["T043"], "canonical_name": "regulation of pseudopodium assembly", "definition": "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. [GOC:pg]"}
{"concept_id": "C1622022", "aliases": ["DDK", "Dbf4-dependent protein kinase complex"], "types": ["T026"], "definition": "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins. [PMID:12045100]", "canonical_name": "Dbf4-dependent protein kinase complex location"}
{"concept_id": "C1622023", "aliases": ["positive regulation of cellular formation", "up-regulation of cellular biosynthetic process", "upregulation of cellular biosynthetic process", "positive regulation of cellular anabolism", "positive regulation of cellular biosynthesis", "up regulation of cellular biosynthetic process", "positive regulation of cellular synthesis"], "types": ["T044"], "canonical_name": "positive regulation of cellular biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. [GOC:mah]"}
{"concept_id": "C1622024", "aliases": ["pseudopodium formation", "pseudopodium extension"], "types": ["T043"], "canonical_name": "pseudopodium assembly", "definition": "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane. [GOC:dph, GOC:mah, GOC:pg, GOC:tb]"}
{"concept_id": "C1622025", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1,2-galactosyltransferase activity", "definition": "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage. [PMID:7522655]"}
{"concept_id": "C1622026", "aliases": [], "types": ["T040"], "canonical_name": "sorocarp morphogenesis", "definition": "The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum. [GOC:kp, GOC:mtg_sensu, PMID:4332228]"}
{"concept_id": "C1622027", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cyclase activity", "definition": "Any process that modulates the frequency, rate or extent of cyclase activity. [GOC:mah]"}
{"concept_id": "C1622028", "aliases": ["CD95 death-inducing signaling complex location", "CD95 DISC", "Fas death-inducing signaling complex", "Fas death-inducing signaling complex location", "CD95 death-inducing signalling complex", "CD95 death-inducing signalling complex location"], "types": ["T026"], "canonical_name": "CD95 death-inducing signaling complex", "definition": "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor. [PMID:12628743, PMID:12655293]"}
{"concept_id": "C1622029", "aliases": ["down-regulation of cyclase activity", "down regulation of cyclase activity", "downregulation of cyclase activity"], "types": ["T044"], "canonical_name": "negative regulation of cyclase activity", "definition": "Any process that stops or reduces the activity of a cyclase. [GOC:mah]"}
{"concept_id": "C1622033", "aliases": ["intrinsic to endosome membrane"], "types": ["T026"], "canonical_name": "intrinsic component of endosome membrane", "definition": "The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622034", "aliases": ["extrinsic to endosome membrane"], "types": ["T026"], "canonical_name": "extrinsic component of endosome membrane", "definition": "The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622035", "aliases": ["up-regulation of protein complex assembly", "positive regulation of protein complex assembly", "up regulation of protein complex assembly", "upregulation of protein complex assembly"], "types": ["T043"], "canonical_name": "positive regulation of protein-containing complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of protein complex assembly. [GOC:mah]"}
{"concept_id": "C1622036", "aliases": ["Elg1-RFC", "Elg1 RFC-like complex location", "Elg1-RLC", "RFC (Elg1)"], "types": ["T026"], "canonical_name": "Elg1 RFC-like complex", "definition": "A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. [PMID:14614842, PMID:23499004, PMID:27664980]"}
{"concept_id": "C1622037", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-glutamine deamination", "definition": "The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein. [GOC:mah]"}
{"concept_id": "C1622038", "aliases": ["UBC13-MMS2 complex location"], "types": ["T026"], "canonical_name": "UBC13-MMS2 complex", "definition": "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p. [GOC:mah, PMID:15772086]"}
{"concept_id": "C1622039", "aliases": ["eIF4G binding"], "types": ["T044"], "canonical_name": "eukaryotic initiation factor 4G binding", "definition": "Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation. [GOC:mah]"}
{"concept_id": "C1622040", "aliases": ["down regulation of defense response", "down-regulation of defense response", "downregulation of defense response"], "types": ["T040"], "canonical_name": "negative regulation of defense response", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. [GOC:mah]"}
{"concept_id": "C1622041", "aliases": ["down-regulation of cell killing", "down regulation of cell killing", "downregulation of cell killing"], "types": ["T043"], "canonical_name": "negative regulation of cell killing", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing. [GOC:mah]"}
{"concept_id": "C1622044", "aliases": ["negative regulation of prostaglandin synthesis", "down-regulation of prostaglandin biosynthetic process", "negative regulation of prostaglandin formation", "down regulation of prostaglandin biosynthetic process", "downregulation of prostaglandin biosynthetic process", "negative regulation of prostaglandin biosynthesis", "negative regulation of prostaglandin anabolism"], "types": ["T044"], "canonical_name": "negative regulation of prostaglandin biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. [GOC:mah]"}
{"concept_id": "C1622045", "aliases": ["intrinsic to plastid outer membrane"], "types": ["T026"], "canonical_name": "intrinsic component of plastid outer membrane", "definition": "The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622046", "aliases": ["RNA-directed RNA polymerase complex location"], "types": ["T026"], "canonical_name": "RNA-directed RNA polymerase complex", "definition": "A protein complex that possesses RNA-directed RNA polymerase activity. [GOC:mah]"}
{"concept_id": "C1622047", "aliases": [], "types": ["T044"], "canonical_name": "organic acid phosphorylation", "definition": "The process of introducing one or more phosphate groups into an organic acid. [GOC:mah]"}
{"concept_id": "C1622048", "aliases": ["anchored to external side of plasma membrane", "anchored to external leaflet of plasma membrane"], "types": ["T026"], "canonical_name": "anchored component of external side of plasma membrane", "definition": "The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622049", "aliases": ["positive regulation of prostaglandin synthesis", "up-regulation of prostaglandin biosynthetic process", "positive regulation of prostaglandin anabolism", "upregulation of prostaglandin biosynthetic process", "positive regulation of prostaglandin formation", "up regulation of prostaglandin biosynthetic process", "positive regulation of prostaglandin biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of prostaglandin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. [GOC:mah]"}
{"concept_id": "C1622052", "aliases": ["Li+ ion binding"], "types": ["T044"], "canonical_name": "lithium ion binding", "definition": "Binding to a lithium ion (Li+). [GOC:mah]"}
{"concept_id": "C1622053", "aliases": ["up-regulation of protein ubiquitination", "upregulation of protein ubiquitination", "up regulation of protein ubiquitination"], "types": ["T044"], "canonical_name": "positive regulation of protein ubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]"}
{"concept_id": "C1622054", "aliases": ["viral RNA-directed RNA polymerase complex location"], "types": ["T026"], "canonical_name": "viral RNA-directed RNA polymerase complex", "definition": "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus. [GOC:mah, PMID:15574411, PMID:15613301]"}
{"concept_id": "C1622055", "aliases": [], "types": ["T044"], "canonical_name": "lipoic acid binding", "definition": "Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1622056", "aliases": ["L-ascorbate binding", "vitamin C binding"], "types": ["T044"], "canonical_name": "L-ascorbic acid binding", "definition": "Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. [GOC:mah]"}
{"concept_id": "C1622057", "aliases": ["box H/ACA small nucleolar ribonucleoprotein complex", "box H/ACA snoRNP complex location", "box H/ACA snoRNP pseudouridylase complex", "box H/ACA snoRNP pseudouridylase complex location", "box H/ACA small nucleolar ribonucleoprotein complex location"], "types": ["T026"], "canonical_name": "box H/ACA snoRNP complex", "definition": "A box H/ACA RNP complex that is located in the nucleolus. [GOC:vw, ISBN:0879695897, PMID:17284456, PMID:20227365]"}
{"concept_id": "C1622058", "aliases": ["box C/D snoRNP ribose-2'-O-methyltransferase complex location", "box C/D small nucleolar ribonucleoprotein complex location", "box C/D snoRNP ribose 2'-O methylase complex", "box C/D small nucleolar ribonucleoprotein complex", "box C/D snoRNP ribose-2'-O-methyltransferase complex", "box C/D snoRNP ribose 2'-O methylase complex location", "box C/D RNP complex location"], "types": ["T026"], "canonical_name": "box C/D RNP complex", "definition": "A ribonucleoprotein complex containing a box C/D type RNA that can carry out ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya. [ISBN:0879695897, PMID:11842104, PMID:17284456]"}
{"concept_id": "C1622059", "aliases": [], "types": ["T044"], "canonical_name": "alkali metal ion binding", "definition": "Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. [GOC:mah]"}
{"concept_id": "C1622060", "aliases": [], "types": ["T045"], "canonical_name": "polycistronic mRNA processing", "definition": "The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules. [GOC:mah]"}
{"concept_id": "C1622061", "aliases": [], "types": ["T044"], "canonical_name": "pigment binding", "definition": "Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin. [GOC:mah]"}
{"concept_id": "C1622062", "aliases": ["oxylipin formation", "oxylipin anabolism", "oxylipin biosynthesis", "oxylipin synthesis"], "types": ["T044"], "canonical_name": "oxylipin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. [GOC:mah, PMID:11960741]"}
{"concept_id": "C1622063", "aliases": ["glycine betaine formation", "N-trimethylglycine biosynthesis", "glycine betaine anabolism", "glycine betaine biosynthesis", "N-trimethylglycine biosynthetic process", "glycine betaine synthesis"], "types": ["T044"], "canonical_name": "glycine betaine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine. [GOC:mah]"}
{"concept_id": "C1622064", "aliases": ["NAT complex", "N-terminal protein acetyltransferase complex location", "NAT complex location"], "types": ["T026"], "canonical_name": "N-terminal protein acetyltransferase complex", "definition": "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. [GOC:mah]"}
{"concept_id": "C1622065", "aliases": ["MAPKKK binding"], "types": ["T044"], "canonical_name": "mitogen-activated protein kinase kinase kinase binding", "definition": "Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. [GOC:bf]"}
{"concept_id": "C1622066", "aliases": ["buoyancy regulation"], "types": ["T039"], "canonical_name": "regulation of buoyancy", "definition": "Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases. [GOC:mah, PATO:0001420]"}
{"concept_id": "C1622067", "aliases": [], "types": ["T026"], "canonical_name": "gas vesicle", "definition": "An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations. [PMID:22147705, PMID:8177173]"}
{"concept_id": "C1622068", "aliases": ["ATP-dependent betaine transporter activity", "ABC-type betaine transmembrane transporter activity", "betaine-transporting ATPase activity", "ATPase-coupled betaine transporter activity"], "types": ["T044"], "canonical_name": "ABC-type betaine transporter activity", "definition": "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in). [GOC:mlg]"}
{"concept_id": "C1622069", "aliases": ["SCF2 complex location"], "types": ["T026"], "canonical_name": "SCF2 complex"}
{"concept_id": "C1622070", "aliases": ["Cul2-RING ubiquitin ligase complex location", "cullin-RING ligase 2", "CRL2 complex", "CDL2 complex", "CDL2 complex location", "CRL2 complex location"], "types": ["T026"], "canonical_name": "Cul2-RING ubiquitin ligase complex", "definition": "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1622071", "aliases": ["ECS complex location"], "types": ["T026"], "canonical_name": "ECS complex"}
{"concept_id": "C1622073", "aliases": [], "types": ["T043"], "canonical_name": "nuclear envelope reassembly"}
{"concept_id": "C1622074", "aliases": [], "types": ["T026"], "canonical_name": "propanediol degradation polyhedral organelle", "definition": "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase. [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081]"}
{"concept_id": "C1622075", "aliases": [], "types": ["T044"], "canonical_name": "myosin III binding", "definition": "Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain. [GOC:mah]"}
{"concept_id": "C1622078", "aliases": ["DCX complex location", "CRL4 complex", "CDL4 complex location", "Cul4A-RING E3 ubiquitin ligase complex location", "CRL4 complex location", "cullin-RING ligase 4A", "DCX complex", "CDL4 complex"], "types": ["T026"], "canonical_name": "Cul4A-RING E3 ubiquitin ligase complex", "definition": "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1622079", "aliases": ["SCF5 complex location"], "types": ["T026"], "canonical_name": "SCF5 complex"}
{"concept_id": "C1622080", "aliases": ["menthol metabolism"], "types": ["T044"], "canonical_name": "menthol metabolic process", "definition": "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol. [GOC:mah]"}
{"concept_id": "C1622081", "aliases": ["Myeloblastosis proto-oncogene protein complex location", "Myeloblastosis proto-oncogene protein complex", "Myb complex location"], "types": ["T026"], "canonical_name": "Myb complex", "definition": "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression. [PMID:12490953, PMID:15545624]"}
{"concept_id": "C1622086", "aliases": [], "types": ["T026"], "canonical_name": "filopodium membrane", "definition": "The portion of the plasma membrane surrounding a filopodium. [GOC:mah]"}
{"concept_id": "C1622087", "aliases": ["ruffle organization and biogenesis", "ruffle organisation"], "types": ["T043"], "canonical_name": "ruffle organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. [GOC:mah, PMID:10036235]"}
{"concept_id": "C1622088", "aliases": ["negative regulation of anthocyanin anabolism", "negative regulation of anthocyanin formation", "downregulation of anthocyanin biosynthetic process", "down-regulation of anthocyanin biosynthetic process", "down regulation of anthocyanin biosynthetic process", "negative regulation of anthocyanin synthesis", "negative regulation of anthocyanin biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of anthocyanin biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins. [GOC:mah]"}
{"concept_id": "C1622089", "aliases": ["negative regulation of BDNF receptor signaling pathway", "negative regulation of BDNF receptor signalling pathway", "downregulation of brain-derived neurotrophic factor receptor signaling pathway", "down regulation of brain-derived neurotrophic factor receptor signaling pathway", "negative regulation of brain-derived neurotrophic factor receptor signalling pathway", "down-regulation of brain-derived neurotrophic factor receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of brain-derived neurotrophic factor receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C1622091", "aliases": ["transcriptional readthrough"], "types": ["T045"], "canonical_name": "transcription antitermination", "definition": "Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s). [ISBN:0198577788, PMID:12456320]"}
{"concept_id": "C1622093", "aliases": ["up-regulation of IP3 receptor activity", "up regulation of IP3 receptor activity", "positive regulation of IP3 receptor activity", "positive regulation of inositol-1,4,5-trisphosphate receptor activity", "upregulation of IP3 receptor activity"], "types": ["T044"], "canonical_name": "positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. [GOC:dph, GOC:mah, GOC:signaling]"}
{"concept_id": "C1622094", "aliases": ["BDNF receptor binding"], "types": ["T044"], "canonical_name": "brain-derived neurotrophic factor receptor binding", "definition": "Binding to a brain-derived neurotrophic factor receptor. [GOC:mah]"}
{"concept_id": "C1622097", "aliases": ["lipid raft distribution"], "types": ["T043"], "canonical_name": "membrane raft distribution", "definition": "The process that establishes the spatial arrangement of membrane rafts within a cellular membrane. [GOC:mah]"}
{"concept_id": "C1622098", "aliases": ["up regulation of brain-derived neurotrophic factor receptor signaling pathway", "up-regulation of brain-derived neurotrophic factor receptor signaling pathway", "positive regulation of BDNF receptor signalling pathway", "positive regulation of BDNF receptor signaling pathway", "upregulation of brain-derived neurotrophic factor receptor signaling pathway", "positive regulation of brain-derived neurotrophic factor receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of brain-derived neurotrophic factor receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C1622099", "aliases": [], "types": ["T026"], "canonical_name": "hyphal tip polarisome", "definition": "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha. [PMID:15976451]"}
{"concept_id": "C1622100", "aliases": ["plasma membrane Sec complex location"], "types": ["T026"], "canonical_name": "plasma membrane Sec complex"}
{"concept_id": "C1622101", "aliases": ["tRNA (m1A) methyltransferase complex location"], "types": ["T026"], "canonical_name": "tRNA (m1A) methyltransferase complex", "definition": "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer. [PMID:10779558, PMID:14739239]"}
{"concept_id": "C1622103", "aliases": ["TRAMP4 complex", "Trf4 complex location", "Trf4 poly(A) polymerase complex", "TRAMP5 complex location", "Trf4 poly(A) polymerase complex location", "TRAMP4 complex location", "Trf4p-Air2p-Mtr4p polyadenylation complex location", "Trf4 complex", "TRAMP complex location", "Trf4p-Air2p-Mtr4p polyadenylation complex", "TRAMP5 complex"], "types": ["T026"], "canonical_name": "TRAMP complex", "definition": "A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control. [PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137]"}
{"concept_id": "C1622106", "aliases": ["fungal-type cell wall organization and biogenesis"], "types": ["T043"], "canonical_name": "fungal-type cell wall organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall. [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622107", "aliases": ["centromere chromatin silencing", "centromeric silencing", "centric heterochromatin formation", "centromeric heterochromatin formation", "centromeric heterochromatin biosynthesis", "chromatin silencing at centromere", "heterochromatic silencing at centromere"], "types": ["T045"], "canonical_name": "pericentric heterochromatin assembly", "definition": "The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA. [GOC:mah, PMID:20206496, PMID:22729156]"}
{"concept_id": "C1622108", "aliases": ["cytosolic proteasome core complex location"], "types": ["T026"], "canonical_name": "cytosolic proteasome core complex", "definition": "The core complex of a proteasome located in the cytosol of a cell. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622109", "aliases": [], "types": ["T044"], "canonical_name": "beta-endorphin binding", "definition": "Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin. [GOC:nln, PMID:6267560]"}
{"concept_id": "C1622111", "aliases": ["nuclear proteasome core complex, beta-subunit complex location"], "types": ["T026"], "canonical_name": "nuclear proteasome core complex, beta-subunit complex", "definition": "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell. [GOC:mah]"}
{"concept_id": "C1622113", "aliases": ["nuclear proteasome regulatory particle, lid subcomplex location"], "types": ["T026"], "canonical_name": "nuclear proteasome regulatory particle, lid subcomplex", "definition": "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell. [GOC:mah]"}
{"concept_id": "C1622115", "aliases": ["ubiquitin ligase binding"], "types": ["T044"], "canonical_name": "ubiquitin protein ligase binding", "definition": "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]"}
{"concept_id": "C1622116", "aliases": ["zymogen activation by proteolytic cleavage"], "types": ["T044"], "canonical_name": "zymogen activation", "definition": "The proteolytic processing of an inactive enzyme to an active form. [GOC:hjd]"}
{"concept_id": "C1622119", "aliases": ["up-regulation of myelination", "up regulation of myelination", "upregulation of myelination"], "types": ["T043"], "canonical_name": "positive regulation of myelination", "definition": "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah]"}
{"concept_id": "C1622120", "aliases": ["protein destabilisation", "negative regulation of protein stability"], "types": ["T043"], "canonical_name": "protein destabilization", "definition": "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. [GOC:mah]"}
{"concept_id": "C1622121", "aliases": ["NADH:plastoquinone reductase complex location", "NADH:plastoquinone reductase complex", "NADH dehydrogenase complex (plastoquinone)", "NADH dehydrogenase complex location (plastoquinone)"], "types": ["T026"], "canonical_name": "NADH dehydrogenase complex (plastoquinone)", "definition": "An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids. [DOI:10.1078/0176-1617-00593, GOC:mah]"}
{"concept_id": "C1622123", "aliases": ["plasma membrane thylakoid membrane"], "types": ["T026"], "canonical_name": "plasma membrane-derived thylakoid membrane", "definition": "The pigmented membrane of a plasma membrane-derived thylakoid. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622124", "aliases": ["G-beta protein subunit binding"], "types": ["T044"], "canonical_name": "G-protein beta-subunit binding", "definition": "Binding to a G-protein beta subunit. [GOC:mah]"}
{"concept_id": "C1622125", "aliases": [], "types": ["T044"], "canonical_name": "G-protein beta/gamma-subunit complex binding", "definition": "Binding to a complex of G-protein beta/gamma subunits. [GOC:nln, GOC:vw]"}
{"concept_id": "C1622126", "aliases": [], "types": ["T044"], "canonical_name": "TCP binding"}
{"concept_id": "C1622128", "aliases": [], "types": ["T044"], "canonical_name": "ferric-enterobactin porter activity"}
{"concept_id": "C1622129", "aliases": ["kinesin activity"], "types": ["T044"], "canonical_name": "kinesin"}
{"concept_id": "C1622130", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nutrient levels", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah]"}
{"concept_id": "C1622132", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1B adrenergic receptor ligand"}
{"concept_id": "C1622133", "aliases": [], "types": ["T044"], "canonical_name": "A1 adenosine receptor binding", "definition": "Binding to an A1 adenosine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622134", "aliases": ["heme catalase activity"], "types": ["T044"], "canonical_name": "haem catalase activity"}
{"concept_id": "C1622135", "aliases": [], "types": ["T044"], "canonical_name": "cofactor-free chloroperoxidase activity"}
{"concept_id": "C1622139", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament localization"}
{"concept_id": "C1622140", "aliases": [], "types": ["T044"], "canonical_name": "aromatic hydrocarbon catabolism"}
{"concept_id": "C1622141", "aliases": [], "types": ["T044"], "canonical_name": "beta-1 adrenergic receptor ligand"}
{"concept_id": "C1622142", "aliases": [], "types": ["T044"], "canonical_name": "A2B adenosine receptor ligand"}
{"concept_id": "C1622143", "aliases": ["endothelin-1 receptor binding"], "types": ["T044"], "canonical_name": "endothelin A receptor binding", "definition": "Binding to an endothelin A receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622144", "aliases": ["AT1 receptor binding"], "types": ["T044"], "canonical_name": "type 1 angiotensin receptor binding", "definition": "Binding to a type 1 angiotensin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622146", "aliases": [], "types": ["T044"], "canonical_name": "C5a anaphylatoxin chemotactic receptor ligand"}
{"concept_id": "C1622148", "aliases": [], "types": ["T044"], "canonical_name": "cannabinoid receptor ligand"}
{"concept_id": "C1622149", "aliases": [], "types": ["T044"], "canonical_name": "haptoglobin binding", "definition": "Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1622150", "aliases": [], "types": ["T044"], "canonical_name": "type 2 cannabinoid receptor ligand"}
{"concept_id": "C1622151", "aliases": ["type 1 EBV-induced G-protein coupled receptor binding", "MIP-3 beta receptor binding"], "types": ["T044"], "canonical_name": "CCR7 chemokine receptor binding", "definition": "Binding to a CCR7 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622152", "aliases": ["eosinophil eotaxin receptor binding"], "types": ["T044"], "canonical_name": "CCR3 chemokine receptor binding", "definition": "Binding to a CCR3 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622153", "aliases": [], "types": ["T044"], "canonical_name": "type 4 serotonin receptor ligand"}
{"concept_id": "C1622154", "aliases": [], "types": ["T044"], "canonical_name": "type 5B serotonin receptor ligand"}
{"concept_id": "C1622155", "aliases": [], "types": ["T044"], "canonical_name": "H9 melatonin receptor ligand"}
{"concept_id": "C1622156", "aliases": [], "types": ["T044"], "canonical_name": "M4 muscarinic acetylcholine receptor binding"}
{"concept_id": "C1622157", "aliases": [], "types": ["T044"], "canonical_name": "type 1 metabotropic GABA receptor binding", "definition": "Binding to a type 1 metabotropic GABA receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622158", "aliases": [], "types": ["T044"], "canonical_name": "type 5 melanocortin receptor ligand"}
{"concept_id": "C1622160", "aliases": [], "types": ["T044"], "canonical_name": "type 2 neuromedin U receptor binding", "definition": "Binding to a type 2 neuromedin U receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622161", "aliases": [], "types": ["T044"], "canonical_name": "prostanoid receptor ligand"}
{"concept_id": "C1622162", "aliases": ["5-hydroxytryptamine 2C receptor binding"], "types": ["T044"], "canonical_name": "type 2C serotonin receptor binding", "definition": "Binding to a type 2C serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622163", "aliases": ["wing hair elongation"], "types": ["T043"], "canonical_name": "imaginal disc-derived wing hair elongation", "definition": "Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles. [GOC:mtg_sensu, PMID:11832234]"}
{"concept_id": "C1622164", "aliases": [], "types": ["T042"], "canonical_name": "prehair localization"}
{"concept_id": "C1622165", "aliases": [], "types": ["T044"], "canonical_name": "taste receptor ligand"}
{"concept_id": "C1622166", "aliases": ["sweet taste receptor binding"], "types": ["T044"], "canonical_name": "type 1 member 3 taste receptor binding", "definition": "Binding to a type 1 member 3 taste receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622167", "aliases": [], "types": ["T044"], "canonical_name": "type 3 somatostatin receptor binding", "definition": "Binding to a type 3 somatostatin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622168", "aliases": [], "types": ["T044"], "canonical_name": "proteinase activated receptor ligand"}
{"concept_id": "C1622169", "aliases": [], "types": ["T044"], "canonical_name": "type 2 somatostatin receptor ligand"}
{"concept_id": "C1622171", "aliases": ["LPA1 receptor binding"], "types": ["T044"], "canonical_name": "Edg-2 lysophosphatidic acid receptor binding", "definition": "Binding to an Edg-2 lysophosphatidic acid receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622172", "aliases": [], "types": ["T044"], "canonical_name": "Edg-3 sphingosine 1-phosphate receptor binding", "definition": "Binding to an Edg-3 sphingosine 1-phosphate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622173", "aliases": ["Tic complex location", "chloroplast inner membrane translocase complex location", "chloroplast inner membrane translocase complex"], "types": ["T026"], "canonical_name": "Tic complex", "definition": "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane. [PMID:12180471, PMID:12393016]"}
{"concept_id": "C1622174", "aliases": [], "types": ["T026"], "canonical_name": "chromoplast outer membrane", "definition": "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope. [GOC:pz]"}
{"concept_id": "C1622176", "aliases": [], "types": ["T044"], "canonical_name": "type 4 metabotropic glutamate receptor binding", "definition": "Binding to a type 4 metabotropic glutamate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622177", "aliases": [], "types": ["T044"], "canonical_name": "type 1 cysteinyl leukotriene receptor binding", "definition": "Binding to a type 1 cysteinyl leukotriene receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622178", "aliases": [], "types": ["T044"], "canonical_name": "cysteinyl leukotriene receptor ligand"}
{"concept_id": "C1622179", "aliases": [], "types": ["T044"], "canonical_name": "somatostatin receptor ligand"}
{"concept_id": "C1622182", "aliases": [], "types": ["T026"], "canonical_name": "organelle outer membrane", "definition": "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. [GOC:mah]"}
{"concept_id": "C1622183", "aliases": ["downregulation of fatty acid beta-oxidation", "down regulation of fatty acid beta-oxidation", "down-regulation of fatty acid beta-oxidation"], "types": ["T043"], "canonical_name": "negative regulation of fatty acid beta-oxidation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation. [GOC:mah]"}
{"concept_id": "C1622184", "aliases": ["down regulation of synaptic plasticity", "down-regulation of synaptic plasticity", "downregulation of synaptic plasticity"], "types": ["T042"], "canonical_name": "negative regulation of synaptic plasticity", "definition": "A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:mah]"}
{"concept_id": "C1622185", "aliases": ["up-regulation of synaptic plasticity", "upregulation of synaptic plasticity", "up regulation of synaptic plasticity"], "types": ["T042"], "canonical_name": "positive regulation of synaptic plasticity", "definition": "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:mah]"}
{"concept_id": "C1622186", "aliases": ["F-actin"], "types": ["T026"], "definition": "A two-stranded helical polymer of the protein actin. [GOC:mah]", "canonical_name": "filamentous actin"}
{"concept_id": "C1622188", "aliases": [], "types": ["T043"], "canonical_name": "pyridoxine transport", "definition": "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. [GOC:mah]"}
{"concept_id": "C1622189", "aliases": ["short-chain-fatty-acid-CoA ligase activity", "short-chain fatty-acid-CoA ligase activity"], "types": ["T044"], "canonical_name": "short-chain fatty acid-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6. [GOC:mah, PMID:34904027]"}
{"concept_id": "C1622190", "aliases": [], "types": ["T044"], "canonical_name": "D2 dopamine receptor ligand"}
{"concept_id": "C1622191", "aliases": ["chloroplast envelope lumen"], "types": ["T026"], "canonical_name": "chloroplast intermembrane space", "definition": "The region between the inner and outer lipid bilayers of a chloroplast envelope. [GOC:mah]"}
{"concept_id": "C1622192", "aliases": [], "types": ["T044"], "canonical_name": "medium-chain fatty acid activation"}
{"concept_id": "C1622193", "aliases": [], "types": ["T044"], "canonical_name": "light transducer activity", "definition": "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell. [GOC:mah, GOC:mlg]"}
{"concept_id": "C1622194", "aliases": [], "types": ["T026"], "canonical_name": "glyoxysomal lumen", "definition": "The volume enclosed by the membranes of a glyoxysome. [GOC:mah]"}
{"concept_id": "C1622195", "aliases": [], "types": ["T044"], "canonical_name": "vitamin B6 transporter activity"}
{"concept_id": "C1622196", "aliases": [], "types": ["T044"], "canonical_name": "very-long-chain fatty acid activation"}
{"concept_id": "C1622197", "aliases": [], "types": ["T044"], "canonical_name": "cortisol receptor activity"}
{"concept_id": "C1622199", "aliases": ["IGF-II binding"], "types": ["T044"], "canonical_name": "insulin-like growth factor II binding", "definition": "Binding to insulin-like growth factor II. [GOC:mah]"}
{"concept_id": "C1622200", "aliases": [], "types": ["T026"], "canonical_name": "cytostome", "definition": "Stable, specialized structure for the ingestion of food by the cell into phagosomes. [PMID:10503189]"}
{"concept_id": "C1622201", "aliases": ["upregulation of synaptic metaplasticity", "up regulation of synaptic metaplasticity", "up-regulation of synaptic metaplasticity"], "types": ["T042"], "canonical_name": "positive regulation of synaptic metaplasticity", "definition": "A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. [GOC:mah, PMID:8658594]"}
{"concept_id": "C1622202", "aliases": [], "types": ["T044"], "canonical_name": "D-glucosyltransferase"}
{"concept_id": "C1622203", "aliases": ["corticosteroid receptor signalling pathway"], "types": ["T044"], "canonical_name": "corticosteroid receptor signaling pathway", "definition": "The series of molecular signals initiated by corticosteroid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, PMID:11027914, PMID:12606724]"}
{"concept_id": "C1622204", "aliases": ["envelope"], "types": ["T026"], "canonical_name": "envelope", "definition": "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. [GOC:mah, GOC:pz]"}
{"concept_id": "C1622205", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal myristoylation domain binding", "definition": "Binding to the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin. [GOC:dl, GOC:jsg, PMID:15632291]"}
{"concept_id": "C1622206", "aliases": ["G-protein coupled histamine receptor binding", "metabotropic histamine receptor binding"], "types": ["T044"], "canonical_name": "G protein-coupled histamine receptor binding", "definition": "Binding to a G protein-coupled (metabotropic) histamine receptor. [GOC:mah, GOC:nln, PMID:12679144]"}
{"concept_id": "C1622207", "aliases": [], "types": ["T044"], "canonical_name": "H1 histamine receptor binding", "definition": "Binding to a H1 histamine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622210", "aliases": ["type 2 orexin receptor binding"], "types": ["T044"], "canonical_name": "type 2 hypocretin receptor binding", "definition": "Binding to a type 2 hypocretin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622211", "aliases": ["ACTH receptor binding", "adrenocorticotropin hormone receptor binding", "corticotropin receptor binding", "adrenocorticotropin receptor binding"], "types": ["T044"], "canonical_name": "corticotropin hormone receptor binding", "definition": "Binding to a corticotropin hormone receptor. [GOC:dph, GOC:mah, GOC:nln]"}
{"concept_id": "C1622212", "aliases": [], "types": ["T044"], "canonical_name": "galanin receptor binding", "definition": "Binding to a galanin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622213", "aliases": [], "types": ["T040"], "canonical_name": "scab formation", "definition": "Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection. [GOC:bf, PMID:15269788]"}
{"concept_id": "C1622214", "aliases": ["FSH receptor binding", "follicle stimulating hormone receptor binding"], "types": ["T044"], "canonical_name": "follicle-stimulating hormone receptor binding", "definition": "Binding to a follicle-stimulating hormone receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622215", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dephosphorylation", "definition": "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. [GOC:bf]"}
{"concept_id": "C1622256", "aliases": [], "types": ["T026"], "canonical_name": "endospore-forming forespore", "definition": "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions. [GOC:jl, GOC:mtg_sensu, ISBN:0697286029]"}
{"concept_id": "C1622259", "aliases": ["cytotoxic T lymphocyte degranulation", "cytotoxic T-cell degranulation", "cytotoxic T-lymphocyte granule exocytosis", "cytotoxic T-lymphocyte degranulation", "cytotoxic T cell granule exocytosis", "cytotoxic T-cell granule exocytosis", "cytotoxic T lymphocyte granule exocytosis"], "types": ["T043"], "canonical_name": "cytotoxic T cell degranulation", "definition": "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell. [ISBN:0781735149]"}
{"concept_id": "C1622260", "aliases": ["regulation of cytotoxic T-cell granule exocytosis", "regulation of cytotoxic T lymphocyte degranulation", "regulation of cytotoxic T-lymphocyte degranulation", "regulation of cytotoxic T lymphocyte granule exocytosis", "regulation of cytotoxic T-cell degranulation", "regulation of cytotoxic T-lymphocyte granule exocytosis", "regulation of cytotoxic T cell granule exocytosis"], "types": ["T043"], "canonical_name": "regulation of cytotoxic T cell degranulation", "definition": "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622261", "aliases": ["negative regulation of cytotoxic T-cell degranulation", "downregulation of cytotoxic T cell degranulation", "negative regulation of cytotoxic T-lymphocyte granule exocytosis", "negative regulation of cytotoxic T lymphocyte degranulation", "negative regulation of cytotoxic T-lymphocyte degranulation", "negative regulation of cytotoxic T-cell granule exocytosis", "negative regulation of cytotoxic T cell granule exocytosis", "down regulation of cytotoxic T cell degranulation", "negative regulation of cytotoxic T lymphocyte granule exocytosis", "down-regulation of cytotoxic T cell degranulation"], "types": ["T043"], "canonical_name": "negative regulation of cytotoxic T cell degranulation", "definition": "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622263", "aliases": ["debranching enzyme complex location"], "types": ["T026"], "canonical_name": "debranching enzyme complex"}
{"concept_id": "C1622264", "aliases": ["exit from nematode dormancy"], "types": ["T040"], "canonical_name": "dauer exit", "definition": "Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development. [GOC:cab1, PMID:12620986]"}
{"concept_id": "C1622265", "aliases": ["positive regulation of cytotoxic T lymphocyte granule exocytosis", "positive regulation of cytotoxic T-cell degranulation", "positive regulation of cytotoxic T-lymphocyte degranulation", "positive regulation of cytotoxic T cell granule exocytosis", "positive regulation of cytotoxic T-cell granule exocytosis", "positive regulation of cytotoxic T-lymphocyte granule exocytosis", "up regulation of cytotoxic T cell degranulation", "up-regulation of cytotoxic T cell degranulation", "upregulation of cytotoxic T cell degranulation", "positive regulation of cytotoxic T lymphocyte degranulation"], "types": ["T043"], "canonical_name": "positive regulation of cytotoxic T cell degranulation", "definition": "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622266", "aliases": ["positive regulation of neutrophil granule exocytosis", "up-regulation of neutrophil degranulation", "up regulation of neutrophil degranulation", "upregulation of neutrophil degranulation"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil degranulation", "definition": "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622271", "aliases": ["neutrophil granule exocytosis"], "types": ["T039"], "canonical_name": "neutrophil degranulation", "definition": "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil. [ISBN:0781735149]"}
{"concept_id": "C1622273", "aliases": ["maintenance of dormancy in the nematode"], "types": ["T040"], "canonical_name": "maintenance of dauer", "definition": "Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development. [GOC:cab1, WB_REF:wm2003ab740]"}
{"concept_id": "C1622281", "aliases": ["chemotaxis to cyclic AMP", "chemotaxis to 3',5'-cAMP", "chemotaxis to adenosine 3',5'-cyclophosphate", "chemotaxis to 3',5' cAMP"], "types": ["T043"], "canonical_name": "chemotaxis to cAMP", "definition": "The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP. [GOC:go_curators]"}
{"concept_id": "C1622285", "aliases": ["regulation of eosinophil granule exocytosis"], "types": ["T043"], "canonical_name": "regulation of eosinophil degranulation", "definition": "Any process that modulates the frequency, rate, or extent of eosinophil degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622296", "aliases": ["positive regulation of NK cell degranulation", "positive regulation of natural killer cell granule exocytosis", "upregulation of natural killer cell degranulation", "up regulation of natural killer cell degranulation", "positive regulation of NK cell granule exocytosis", "up-regulation of natural killer cell degranulation"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell degranulation", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622297", "aliases": ["NK cell granule exocytosis", "natural killer cell granule exocytosis", "NK cell degranulation"], "types": ["T043"], "canonical_name": "natural killer cell degranulation", "definition": "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell. [ISBN:0781735149]"}
{"concept_id": "C1622299", "aliases": [], "types": ["T043"], "canonical_name": "dictyosome vesicle budding"}
{"concept_id": "C1622302", "aliases": [], "types": ["T044"], "canonical_name": "PHA biosynthesis"}
{"concept_id": "C1622314", "aliases": [], "types": ["T043"], "canonical_name": "chemotaxis to folate", "definition": "The directed movement of a motile cell or organism in response to the presence of folate. [GOC:go_curators]"}
{"concept_id": "C1622316", "aliases": ["nematode entry into dormancy"], "types": ["T040"], "canonical_name": "dauer entry", "definition": "Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development. [GOC:cab1, GOC:kmv, PMID:10077613]"}
{"concept_id": "C1622320", "aliases": ["mitochondrial glutamate synthase complex location (NADH)"], "types": ["T026"], "canonical_name": "mitochondrial glutamate synthase complex (NADH)", "definition": "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity. [GOC:jl, PMID:7047525]"}
{"concept_id": "C1622323", "aliases": ["enucleate red blood cell differentiation", "enucleate RBC differentiation"], "types": ["T043"], "canonical_name": "enucleate erythrocyte differentiation", "definition": "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus. [GOC:go_curators]"}
{"concept_id": "C1622324", "aliases": [], "types": ["T044"], "canonical_name": "catalysis of free radical formation"}
{"concept_id": "C1622325", "aliases": ["downregulation of leukocyte degranulation", "down-regulation of leukocyte degranulation", "negative regulation of immune cell degranulation", "negative regulation of leucocyte degranulation", "down regulation of leukocyte degranulation"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte degranulation", "definition": "Any process that stops, prevents, or reduces the rate of leukocyte degranulation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1622326", "aliases": [], "types": ["T026"], "canonical_name": "conjugation tube tip"}
{"concept_id": "C1622329", "aliases": ["negative regulation of CD8-positive T lymphocyte differentiation", "down regulation of CD8-positive, alpha-beta T cell differentiation", "negative regulation of CD8-positive T-lymphocyte differentiation", "negative regulation of CD8-positive T-cell differentiation", "negative regulation of CD8-positive, alpha beta T lymphocyte differentiation", "down-regulation of CD8-positive, alpha-beta T cell differentiation", "negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation", "negative regulation of CD8-positive, alpha beta T-cell differentiation", "downregulation of CD8-positive, alpha-beta T cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of CD8-positive, alpha-beta T cell differentiation", "definition": "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1622330", "aliases": ["2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity"], "types": ["T044"], "canonical_name": "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "definition": "Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. [GOC:kd, PMID:9083048]"}
{"concept_id": "C1622331", "aliases": ["apical cell junction complex", "apical junction complex location", "apical junction", "apical cell junction complex location"], "types": ["T026"], "canonical_name": "apical junction complex", "definition": "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]"}
{"concept_id": "C1622332", "aliases": ["nucleate red blood cell maturation", "nucleate RBC maturation"], "types": ["T043"], "canonical_name": "nucleate erythrocyte maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. [GOC:devbiol, GOC:jl]"}
{"concept_id": "C1622334", "aliases": ["mycotoxin anabolism", "mycotoxin synthesis", "mycotoxin formation", "mycotoxin biosynthesis"], "types": ["T044"], "canonical_name": "mycotoxin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus. [GOC:jl]"}
{"concept_id": "C1622335", "aliases": ["mycotoxin breakdown", "mycotoxin catabolism", "mycotoxin degradation"], "types": ["T044"], "canonical_name": "mycotoxin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus. [GOC:jl]"}
{"concept_id": "C1622336", "aliases": ["mycotoxin metabolism"], "types": ["T044"], "canonical_name": "mycotoxin metabolic process", "definition": "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus. [GOC:jl]"}
{"concept_id": "C1622339", "aliases": [], "types": ["T044"], "canonical_name": "aflatoxin B2 metabolic process"}
{"concept_id": "C1622340", "aliases": ["hydrocortisone secretion"], "types": ["T042"], "canonical_name": "cortisol secretion", "definition": "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. [PMID:11027914]"}
{"concept_id": "C1622342", "aliases": ["upregulation of MAPK activity", "up regulation of MAPK activity", "up-regulation of MAPK activity", "positive regulation of mitogen activated protein kinase activity", "positive regulation of mitogen-activated protein kinase activity"], "types": ["T044"], "canonical_name": "positive regulation of MAP kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]"}
{"concept_id": "C1622343", "aliases": ["NT5 binding"], "types": ["T044"], "canonical_name": "NT-5 binding"}
{"concept_id": "C1622344", "aliases": [], "types": ["T043"], "canonical_name": "SLMV biogenesis"}
{"concept_id": "C1622347", "aliases": ["migration within host"], "types": ["T040"], "canonical_name": "migration in host", "definition": "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1622352", "aliases": [], "types": ["T026"], "canonical_name": "endospore cortex", "definition": "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan. [GOC:mlg]"}
{"concept_id": "C1622353", "aliases": ["cytoplasmic DNA replication factor C complex location", "cytoplasmic clamp loader", "cytoplasmic RFC"], "types": ["T026"], "canonical_name": "cytoplasmic DNA replication factor C complex", "definition": "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species. [GOC:mtg_sensu, PMID:14646196, PMID:16172520]"}
{"concept_id": "C1622355", "aliases": ["PTS receptor"], "types": ["T044"], "canonical_name": "peroxisome targeting signal receptor"}
{"concept_id": "C1622368", "aliases": ["spliceosome complex disassembly"], "types": ["T045"], "canonical_name": "spliceosomal complex disassembly", "definition": "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure. [GOC:krc, ISBN:0879695897]"}
{"concept_id": "C1622370", "aliases": ["base of shmoo tip"], "types": ["T026"], "canonical_name": "conjugation tube base"}
{"concept_id": "C1622372", "aliases": ["membrane ruffle"], "types": ["T026"], "definition": "The portion of the plasma membrane surrounding a ruffle. [GOC:mah]", "canonical_name": "ruffle membrane"}
{"concept_id": "C1622373", "aliases": [], "types": ["T042"], "canonical_name": "compound eye photoreceptor cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. [GOC:go_curators]"}
{"concept_id": "C1622374", "aliases": ["branching morphogenesis"], "types": ["T040"], "canonical_name": "morphogenesis of a branching structure", "definition": "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. [ISBN:0721662544]"}
{"concept_id": "C1622375", "aliases": [], "types": ["T042"], "canonical_name": "lymph vessel development", "definition": "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. [GOC:dph, UBERON:0001473]"}
{"concept_id": "C1622376", "aliases": ["regulation of cytokine mediated signalling pathway", "regulation of cytokine mediated signaling pathway", "regulation of cytokine and chemokine mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of cytokine-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway. [GOC:hjd]"}
{"concept_id": "C1622377", "aliases": ["down-regulation of cytokine mediated signaling pathway", "negative regulation of cytokine mediated signaling pathway", "negative regulation of cytokine and chemokine mediated signaling pathway", "downregulation of cytokine mediated signaling pathway", "down regulation of cytokine mediated signaling pathway", "negative regulation of cytokine mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of cytokine-mediated signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway. [GOC:hjd]"}
{"concept_id": "C1622378", "aliases": ["sebocytes differentiation"], "types": ["T042"], "definition": "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell. [GOC:mgi_curators, PMID:15737203]", "canonical_name": "sebaceous gland cell differentiation"}
{"concept_id": "C1622379", "aliases": [], "types": ["T044"], "canonical_name": "isoglobotriaosylceramide synthase"}
{"concept_id": "C1622380", "aliases": ["G-alpha protein subunit binding"], "types": ["T044"], "canonical_name": "G-protein alpha-subunit binding", "definition": "Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. [GOC:hjd]"}
{"concept_id": "C1622381", "aliases": [], "types": ["T040"], "canonical_name": "hair follicle development", "definition": "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. [GOC:dph, UBERON:0002073]"}
{"concept_id": "C1622382", "aliases": [], "types": ["T040"], "canonical_name": "fast control of arterial pressure"}
{"concept_id": "C1622383", "aliases": [], "types": ["T042"], "canonical_name": "blood vessel remodeling", "definition": "The reorganization or renovation of existing blood vessels. [GOC:hjd]"}
{"concept_id": "C1622384", "aliases": ["adenosine receptor signaling pathway", "adenosine receptor signaling pathway, G-protein coupled", "P1 receptor signaling pathway", "adenosine receptor signalling pathway"], "types": ["T044"], "canonical_name": "G protein-coupled adenosine receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. [GOC:dph]"}
{"concept_id": "C1622385", "aliases": ["nursing behavior"], "types": ["T038"], "canonical_name": "suckling behavior", "definition": "Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. [GOC:dph, GOC:pr]"}
{"concept_id": "C1622386", "aliases": ["renin-angiotensin blood pressure control", "circulatory renin-angiotensin control of blood pressure"], "types": ["T038"], "canonical_name": "control of blood pressure by circulatory renin-angiotensin"}
{"concept_id": "C1622387", "aliases": [], "types": ["T039"], "canonical_name": "vasopressin control of blood pressure"}
{"concept_id": "C1622390", "aliases": ["positive regulation of membrane attack complex formation", "positive regulation of activation of MAC", "upregulation of activation of membrane attack complex", "positive regulation of MAC formation", "positive regulation of MAC assembly", "up-regulation of activation of membrane attack complex", "positive regulation of membrane attack complex assembly", "up regulation of activation of membrane attack complex"], "types": ["T043"], "canonical_name": "positive regulation of activation of membrane attack complex", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. [GOC:hjd]"}
{"concept_id": "C1622391", "aliases": [], "types": ["T039"], "canonical_name": "norepinephrine-epinephrine blood pressure control"}
{"concept_id": "C1622396", "aliases": [], "types": ["T043"], "canonical_name": "detection of carbon dioxide by vasomotor center", "definition": "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system. [ISBN:0721643949]"}
{"concept_id": "C1622397", "aliases": [], "types": ["T039"], "canonical_name": "angiotensin mediated control of renal output"}
{"concept_id": "C1622398", "aliases": [], "types": ["T040"], "canonical_name": "diet induced thermogenesis", "definition": "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system. [PMID:12161655]"}
{"concept_id": "C1622399", "aliases": [], "types": ["T040"], "canonical_name": "detection of dietary excess", "definition": "The neurological process in which the brain senses excessive caloric intake. [PMID:12161655]"}
{"concept_id": "C1622400", "aliases": ["cardiac inotropy", "heart inotropy"], "types": ["T039"], "canonical_name": "regulation of the force of heart contraction", "definition": "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. [GOC:dph, GOC:tb, PMID:10358008]"}
{"concept_id": "C1622402", "aliases": ["norepinephrine-epinephrine vasodilation during blood pressure regulation", "vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure", "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure"], "types": ["T039"], "canonical_name": "norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure", "definition": "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change. [GOC:mtg_cardio, PMID:10358008]"}
{"concept_id": "C1622403", "aliases": [], "types": ["T044"], "canonical_name": "long-chain fatty acid activation"}
{"concept_id": "C1622405", "aliases": ["inhibitory G-protein coupled receptor phosphorylation"], "types": ["T044"], "canonical_name": "inhibitory G protein-coupled receptor phosphorylation", "definition": "The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site. [PMID:8396717]"}
{"concept_id": "C1622406", "aliases": ["renin-angiotensin regulation of blood vessel size"], "types": ["T039"], "canonical_name": "regulation of blood vessel size by renin-angiotensin"}
{"concept_id": "C1622409", "aliases": [], "types": ["T044"], "canonical_name": "death receptor ligand"}
{"concept_id": "C1622418", "aliases": [], "types": ["T026"], "definition": "Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]", "canonical_name": "vesicle"}
{"concept_id": "C1622421", "aliases": [], "types": ["T026"], "definition": "The large subunit of the 80s ribosome of eukaryotes. It is composed of the 28S RIBOSOMAL RNA, the 5.8S RIBOSOMAL RNA, the 5S RIBOSOMAL RNA, and about 50 different RIBOSOMAL PROTEINS.", "canonical_name": "60S ribosomal subunit"}
{"concept_id": "C1622430", "aliases": ["protein amino acid N-linked glycosylation"], "types": ["T044"], "canonical_name": "protein N-linked glycosylation", "definition": "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]"}
{"concept_id": "C1622435", "aliases": [], "types": ["T044"], "canonical_name": "triterpene metabolism"}
{"concept_id": "C1622437", "aliases": [], "types": ["T042"], "canonical_name": "haltere development", "definition": "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings. [GOC:jid, http://www.earthlife.net]"}
{"concept_id": "C1622438", "aliases": [], "types": ["T044"], "canonical_name": "activation of APC-Cdc20 complex activity"}
{"concept_id": "C1622441", "aliases": ["regulation of progression through syncytial blastoderm mitotic cell cycle", "modulation of syncytial blastoderm cell cycle progression", "regulation of syncytial blastoderm cell cycle progression", "syncytial blastoderm cell cycle regulation", "regulation of syncytial blastoderm cell cycle", "syncytial blastoderm cell cycle modulation"], "types": ["T043"], "canonical_name": "regulation of syncytial blastoderm mitotic cell cycle", "definition": "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1622443", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome bc1 complex"}
{"concept_id": "C1622444", "aliases": ["guanine ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type guanine transporter activity", "definition": "Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in). [RHEA:20832]"}
{"concept_id": "C1622445", "aliases": ["rRNA biosynthesis"], "types": ["T045"], "canonical_name": "rRNA synthesis"}
{"concept_id": "C1622448", "aliases": [], "types": ["T039"], "canonical_name": "response to light stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. [GOC:go_curators, ISBN:0582227089]"}
{"concept_id": "C1622452", "aliases": ["diterpene cyclase activity"], "types": ["T044"], "canonical_name": "diterpene cyclase activity"}
{"concept_id": "C1622453", "aliases": ["glucose mediated signalling"], "types": ["T044"], "canonical_name": "glucose mediated signaling pathway", "definition": "The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes. [GOC:sm]"}
{"concept_id": "C1622458", "aliases": ["farnesyl diphosphate anabolism, mevalonate pathway", "isoprenoid pathway", "farnesyl diphosphate synthesis, mevalonate pathway", "farnesyl diphosphate formation, mevalonate pathway"], "types": ["T044"], "canonical_name": "farnesyl diphosphate biosynthetic process, mevalonate pathway", "definition": "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols. [GOC:pz, MetaCyc:PWY-922]"}
{"concept_id": "C1622461", "aliases": [], "types": ["T044"], "canonical_name": "phosphate ABC transporter"}
{"concept_id": "C1622462", "aliases": [], "types": ["T044"], "canonical_name": "manganese ABC transporter"}
{"concept_id": "C1622463", "aliases": ["oligosaccharide ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type oligosaccharide transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in). [EC:7.5.2.2]"}
{"concept_id": "C1622465", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of transmembrane electrochemical gradient", "definition": "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. [GOC:mah, GOC:sm]"}
{"concept_id": "C1622466", "aliases": [], "types": ["T043"], "canonical_name": "radial microtubular system formation", "definition": "Formation of radial microtubular systems during male meiotic cytokinesis in plants. [GOC:syr]"}
{"concept_id": "C1622467", "aliases": ["phosphonate ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type phosphonate transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). [RHEA:18065]"}
{"concept_id": "C1622468", "aliases": [], "types": ["T044"], "canonical_name": "monosaccharide ABC transporter"}
{"concept_id": "C1622471", "aliases": ["transition from vegetative to reproductive phase"], "types": ["T042"], "canonical_name": "vegetative to reproductive phase transition of meristem", "definition": "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence. [GOC:tb]"}
{"concept_id": "C1622472", "aliases": [], "types": ["T044"], "canonical_name": "peptide antigen ABC transporter"}
{"concept_id": "C1622473", "aliases": [], "types": ["T044"], "canonical_name": "capsular-polysaccharide ABC transporter"}
{"concept_id": "C1622474", "aliases": ["beta-glucan ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type beta-glucan transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out). [RHEA:18453]"}
{"concept_id": "C1622475", "aliases": ["rhamnogalacturonan I formation", "rhamnogalacturonan I synthesis", "rhamnogalacturonan I anabolism", "rhamnogalacturonan I biosynthesis"], "types": ["T044"], "canonical_name": "rhamnogalacturonan I biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide. [GOC:pz]"}
{"concept_id": "C1622477", "aliases": [], "types": ["T044"], "canonical_name": "ferric-hydroxamate ABC transporter"}
{"concept_id": "C1622478", "aliases": [], "types": ["T044"], "canonical_name": "delta(6)-acyl CoA desaturase activity"}
{"concept_id": "C1622479", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid delta(6)-desaturase activity"}
{"concept_id": "C1622481", "aliases": [], "types": ["T044"], "canonical_name": "diterpene metabolism"}
{"concept_id": "C1622482", "aliases": [], "types": ["T044"], "canonical_name": "linoleate desaturase activity"}
{"concept_id": "C1622483", "aliases": [], "types": ["T044"], "canonical_name": "diterpene biosynthesis"}
{"concept_id": "C1622484", "aliases": [], "types": ["T044"], "canonical_name": "triterpene biosynthesis"}
{"concept_id": "C1622486", "aliases": [], "types": ["T044"], "canonical_name": "1-phosphatidylinositol-4-phosphate kinase activity"}
{"concept_id": "C1622487", "aliases": ["protein amino acid O-linked glycosylation via tyrosine"], "types": ["T044"], "canonical_name": "protein O-linked glycosylation via tyrosine", "definition": "The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen. [RESID:AA0157]"}
{"concept_id": "C1622488", "aliases": ["protein amino acid O-linked glycosylation via hydroxylysine"], "types": ["T044"], "canonical_name": "protein O-linked glycosylation via hydroxylysine", "definition": "The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine. [RESID:AA0153]"}
{"concept_id": "C1622491", "aliases": [], "types": ["T040"], "canonical_name": "sensory perception of fast pain", "definition": "The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds. [http://www.spine-health.com/]"}
{"concept_id": "C1622499", "aliases": [], "types": ["T043"], "definition": "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. [GOC:add, ISBN:0781735149]", "canonical_name": "myeloid cell differentiation"}
{"concept_id": "C1622501", "aliases": [], "types": ["T043"], "definition": "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]", "canonical_name": "cell migration"}
{"concept_id": "C1622508", "aliases": [], "types": ["T044"], "canonical_name": "protein membrane anchor"}
{"concept_id": "C1622512", "aliases": [], "types": ["T026"], "canonical_name": "platelet dense granule membrane", "definition": "The lipid bilayer surrounding the platelet dense granule. [GOC:mah]"}
{"concept_id": "C1622513", "aliases": ["platelet alpha-granule membrane"], "types": ["T026"], "canonical_name": "platelet alpha granule membrane", "definition": "The lipid bilayer surrounding the platelet alpha granule. [GOC:mah, PMID:8467233]"}
{"concept_id": "C1622515", "aliases": ["holo-[acyl-carrier-protein] synthesis", "holo-[acyl-carrier protein] biosynthesis", "holo-[acyl-carrier-protein] formation", "holo-[acyl-carrier-protein] anabolism", "holo-[acyl-carrier-protein] biosynthesis"], "types": ["T044"], "canonical_name": "holo-[acyl-carrier-protein] biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]. [GOC:mlg]"}
{"concept_id": "C1622516", "aliases": [], "types": ["T043"], "canonical_name": "septin ring disassembly", "definition": "The controlled breakdown of a septin ring. [GOC:mah]"}
{"concept_id": "C1622517", "aliases": [], "types": ["T043"], "canonical_name": "dendrite regeneration", "definition": "The regrowth of dendrites in response to their loss or damage. [GOC:dgh, GOC:dph, GOC:tb]"}
{"concept_id": "C1622518", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microtubule polymerization", "definition": "Any process that modulates the frequency, rate or extent of microtubule polymerization. [GOC:mah]"}
{"concept_id": "C1622519", "aliases": ["septin complex location"], "types": ["T026"], "canonical_name": "septin complex", "definition": "A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric. [GOC:mah, PMID:15385632]"}
{"concept_id": "C1622520", "aliases": ["down-regulation of microtubule polymerization or depolymerization", "downregulation of microtubule polymerization or depolymerization", "down regulation of microtubule polymerization or depolymerization"], "types": ["T043"], "canonical_name": "negative regulation of microtubule polymerization or depolymerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. [GOC:mah]"}
{"concept_id": "C1622521", "aliases": ["septin ring organisation"], "types": ["T043"], "canonical_name": "septin ring organization", "definition": "Control of the formation, spatial distribution, and breakdown of the septin ring. [GOC:mah]"}
{"concept_id": "C1622525", "aliases": ["juxtamembrane"], "types": ["T026"], "canonical_name": "juxtamembrane"}
{"concept_id": "C1622526", "aliases": [], "types": ["T043"], "canonical_name": "regulation of conjugation with cellular fusion", "definition": "Any process that modulates the rate or frequency of conjugation with cellular fusion. [GOC:mah]"}
{"concept_id": "C1622527", "aliases": [], "types": ["T044"], "canonical_name": "rhizobactin 1021 biosynthetic process, peptide modification"}
{"concept_id": "C1622528", "aliases": [], "types": ["T043"], "canonical_name": "induction of conjugation upon nitrogen starvation", "definition": "The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation. [GOC:mah]"}
{"concept_id": "C1622530", "aliases": [], "types": ["T045"], "canonical_name": "snRNA pseudouridine synthesis", "definition": "The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. [GOC:mah]"}
{"concept_id": "C1622531", "aliases": ["SCF-dependent proteasomal ubiquitin-dependent protein breakdown", "SCF-dependent proteasomal ubiquitin-dependent protein catabolism", "SCF-dependent proteasomal ubiquitin-dependent protein degradation"], "types": ["T044"], "canonical_name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. [PMID:15380083]"}
{"concept_id": "C1622532", "aliases": [], "types": ["T044"], "canonical_name": "ferrichrome biosynthetic process, peptide formation"}
{"concept_id": "C1622533", "aliases": ["1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation", "DIF-1 biosynthesis", "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis", "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism", "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis", "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process"], "types": ["T044"], "canonical_name": "DIF-1 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells. [GOC:mah, PMID:10706822]"}
{"concept_id": "C1622535", "aliases": [], "types": ["T044"], "canonical_name": "chrysobactin biosynthetic process, peptide modification"}
{"concept_id": "C1622536", "aliases": [], "types": ["T040"], "canonical_name": "regulation of aggregation during fruiting body formation"}
{"concept_id": "C1622537", "aliases": ["SNARE complex location"], "types": ["T026"], "canonical_name": "SNARE complex", "definition": "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]"}
{"concept_id": "C1622538", "aliases": ["regulation of fruiting body formation", "regulation of fruiting body development"], "types": ["T040"], "canonical_name": "regulation of reproductive fruiting body development", "definition": "Any process that modulates the frequency, rate or extent of reproductive fruiting body development. [GOC:mah]"}
{"concept_id": "C1622539", "aliases": ["WAVE complex location", "WRC", "WAVE regulatory complex location", "WAVE regulatory complex", "SCAR complex location", "WAVE complex"], "types": ["T026"], "canonical_name": "SCAR complex", "definition": "A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction. [GOC:hla, GOC:pg, PMID:12181570, PMID:24036345, PMID:24630101]"}
{"concept_id": "C1622541", "aliases": ["arabinogalactanase activity", "endo-1,4-beta-galactanase activity", "galactanase activity", "arabinogalactan 4-beta-D-galactanohydrolase activity"], "types": ["T044"], "canonical_name": "arabinogalactan endo-1,4-beta-galactosidase activity", "definition": "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans. [EC:3.2.1.89, GOC:mlg]"}
{"concept_id": "C1622542", "aliases": ["protein docking during posttranslational protein targeting to membrane", "Sec-translated protein complex assembly", "posttranslational protein targeting to membrane, docking", "posttranslational protein membrane targeting, docking"], "types": ["T043"], "canonical_name": "post-translational protein targeting to membrane, docking", "definition": "The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex. [PMID:12518217, PMID:8707814]"}
{"concept_id": "C1622543", "aliases": [], "types": ["T044"], "canonical_name": "siderophore biosynthetic process, peptide formation"}
{"concept_id": "C1622544", "aliases": [], "types": ["T042"], "canonical_name": "shell calcification", "definition": "The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell. [GOC:mah, PMID:15132736]"}
{"concept_id": "C1622545", "aliases": ["Sec62/63 complex location", "ER protein translocation subcomplex", "Sec62/Sec63 complex location", "ER protein translocation subcomplex location", "Sec62/63 complex"], "types": ["T026"], "canonical_name": "Sec62/Sec63 complex", "definition": "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p. [PMID:12518317, PMID:14617809]"}
{"concept_id": "C1622546", "aliases": ["palmitoyltransferase complex location"], "types": ["T026"], "canonical_name": "palmitoyltransferase complex", "definition": "A protein complex with palmitoyltransferase activity. [GOC:hjd]"}
{"concept_id": "C1622549", "aliases": ["ferrichrome biosynthesis", "ferrichrome formation", "ferrichrome anabolism", "ferrichrome synthesis"], "types": ["T044"], "canonical_name": "ferrichrome biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1622550", "aliases": ["intrinsic to external leaflet of cell outer membrane", "intrinsic to external side of outer membrane", "intrinsic to external side of cell outer membrane"], "types": ["T026"], "canonical_name": "intrinsic component of external side of cell outer membrane", "definition": "The component of the cell outer membrane consisting of the gene products and protein complexes that penetrate the external side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor. [GOC:dos, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622551", "aliases": ["poly(A) nuclease complex location", "PAN complex location", "poly(A) nuclease complex"], "types": ["T026"], "canonical_name": "PAN complex", "definition": "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces. [PMID:9774670]"}
{"concept_id": "C1622552", "aliases": ["protein acetyltransferase complex location"], "types": ["T026"], "canonical_name": "protein acetyltransferase complex", "definition": "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule. [GOC:bf]"}
{"concept_id": "C1622553", "aliases": ["internal leaflet of cell outer membrane", "internal side of outer membrane", "internal side of cell outer membrane"], "types": ["T026"], "canonical_name": "periplasmic side of cell outer membrane", "definition": "The side (leaflet) of the outer membrane that faces the periplasm of the cell. [GOC:mlg, GOC:mtg_sensu]"}
{"concept_id": "C1622554", "aliases": ["intrinsic to endoplasmic reticulum membrane"], "types": ["T026"], "canonical_name": "intrinsic component of endoplasmic reticulum membrane", "definition": "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622555", "aliases": ["intrinsic to peroxisomal membrane"], "types": ["T026"], "canonical_name": "intrinsic component of peroxisomal membrane", "definition": "The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622556", "aliases": ["extrinsic to external side of plasma membrane, in periplasmic space"], "types": ["T026"], "canonical_name": "extrinsic component of periplasmic side of plasma membrane", "definition": "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622557", "aliases": ["ascospore-type prospore formation"], "types": ["T043"], "canonical_name": "ascospore-type prospore assembly", "definition": "During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane. [GOC:mah, PMID:14702385]"}
{"concept_id": "C1622558", "aliases": ["regulation of cellular formation", "regulation of cellular biosynthesis", "regulation of cellular anabolism", "regulation of cellular synthesis"], "types": ["T044"], "canonical_name": "regulation of cellular biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. [GOC:mah]"}
{"concept_id": "C1622559", "aliases": ["uropodium membrane"], "types": ["T026"], "canonical_name": "uropod membrane", "definition": "The portion of the plasma membrane surrounding a uropod. [GOC:mah]"}
{"concept_id": "C1622560", "aliases": ["trailing edge membrane"], "types": ["T026"], "canonical_name": "cell trailing edge membrane", "definition": "The portion of the plasma membrane surrounding the trailing edge of a motile cell. [GOC:mah]"}
{"concept_id": "C1622561", "aliases": [], "types": ["T025"], "canonical_name": "lateral part of motile cell", "definition": "The area of a motile cell perpendicular to the direction of movement. [GOC:pg, GOC:pr]"}
{"concept_id": "C1622564", "aliases": ["TRAIL death-inducing signalling complex location", "TRAIL death-inducing signalling complex", "TRAIL death-inducing signaling complex location", "TRAIL DISC"], "types": ["T026"], "canonical_name": "TRAIL death-inducing signaling complex", "definition": "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor. [PMID:12628743, PMID:12655293]"}
{"concept_id": "C1622567", "aliases": ["lymphocyte co-stimulation"], "types": ["T043"], "canonical_name": "lymphocyte costimulation", "definition": "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. [ISBN:0781735149]"}
{"concept_id": "C1622568", "aliases": [], "types": ["T026"], "canonical_name": "pseudopodium membrane", "definition": "The portion of the plasma membrane surrounding a pseudopodium. [GOC:mah]"}
{"concept_id": "C1622569", "aliases": ["down-regulation of stalk cell differentiation", "downregulation of stalk cell differentiation", "down regulation of stalk cell differentiation", "negative regulation of stalk cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of sorocarp stalk cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum. [GOC:kp, GOC:mtg_sensu, PMID:4338436]"}
{"concept_id": "C1622570", "aliases": [], "types": ["T044"], "canonical_name": "Ran protein signal transduction", "definition": "The series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state. [GOC:mah]"}
{"concept_id": "C1622571", "aliases": [], "types": ["T044"], "canonical_name": "regulation of guanylate cyclase activity", "definition": "Any process that modulates the frequency, rate or extent of guanylate cyclase activity. [GOC:mah]"}
{"concept_id": "C1622572", "aliases": ["T lymphocyte costimulation", "T-cell costimulation", "T-cell co-stimulation", "T-lymphocyte costimulation", "T cell co-stimulation"], "types": ["T043"], "canonical_name": "T cell costimulation", "definition": "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. [ISBN:0781735149]"}
{"concept_id": "C1622573", "aliases": ["B-cell costimulation", "B-lymphocyte co-stimulation", "B lymphocyte costimulation", "B cell co-stimulation", "B-cell co-stimulation", "B-lymphocyte costimulation", "B lymphocyte co-stimulation"], "types": ["T043"], "canonical_name": "B cell costimulation", "definition": "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation. [ISBN:0781735149]"}
{"concept_id": "C1622574", "aliases": ["negative regulation of cellular degradation", "negative regulation of cellular catabolism", "down-regulation of cellular catabolic process", "down regulation of cellular catabolic process", "downregulation of cellular catabolic process", "negative regulation of cellular breakdown"], "types": ["T044"], "canonical_name": "negative regulation of cellular catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. [GOC:mah]"}
{"concept_id": "C1622575", "aliases": [], "types": ["T044"], "canonical_name": "membrane protein intracellular domain proteolysis", "definition": "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. [PMID:12808018]"}
{"concept_id": "C1622576", "aliases": ["retinal ganglion cell axon pathfinding"], "types": ["T043"], "canonical_name": "retinal ganglion cell axon guidance", "definition": "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:ejs]"}
{"concept_id": "C1622577", "aliases": ["folate detection", "folic acid detection", "folic acid sensing", "folate sensing", "detection of folate"], "types": ["T043"], "canonical_name": "detection of folic acid", "definition": "The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal. [GOC:pg]"}
{"concept_id": "C1622579", "aliases": ["intrinsic to vacuolar membrane"], "types": ["T026"], "canonical_name": "intrinsic component of vacuolar membrane", "definition": "The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622582", "aliases": ["integral to nuclear outer membrane"], "types": ["T026"], "canonical_name": "integral component of nuclear outer membrane", "definition": "The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622583", "aliases": ["extrinsic to nuclear outer membrane"], "types": ["T026"], "canonical_name": "extrinsic component of nuclear outer membrane", "definition": "The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622584", "aliases": ["downregulation of sulfur amino acid metabolic process", "down-regulation of sulfur amino acid metabolic process", "down regulation of sulfur amino acid metabolic process", "negative regulation of sulfur amino acid metabolism"], "types": ["T043"], "canonical_name": "negative regulation of sulfur amino acid metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. [GOC:mah]"}
{"concept_id": "C1622585", "aliases": ["down regulation of protein complex assembly", "downregulation of protein complex assembly", "negative regulation of protein complex assembly", "down-regulation of protein complex assembly"], "types": ["T043"], "canonical_name": "negative regulation of protein-containing complex assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. [GOC:mah]"}
{"concept_id": "C1622586", "aliases": ["RNAi effector complex location"], "types": ["T026"], "canonical_name": "RNAi effector complex", "definition": "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. [GOC:mah, PMID:14704433]"}
{"concept_id": "C1622587", "aliases": ["E2 complex location"], "types": ["T026"], "canonical_name": "E2 complex"}
{"concept_id": "C1622589", "aliases": ["up-regulation of sulfur amino acid metabolic process", "up regulation of sulfur amino acid metabolic process", "upregulation of sulfur amino acid metabolic process", "positive regulation of sulfur amino acid metabolism"], "types": ["T043"], "canonical_name": "positive regulation of sulfur amino acid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. [GOC:mah]"}
{"concept_id": "C1622590", "aliases": [], "types": ["T044"], "canonical_name": "translation initiation factor binding", "definition": "Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. [GOC:mah]"}
{"concept_id": "C1622591", "aliases": ["up regulation of cell projection organization", "positive regulation of cell projection organisation", "upregulation of cell projection organization", "positive regulation of cell projection organization and biogenesis", "up-regulation of cell projection organization"], "types": ["T043"], "canonical_name": "positive regulation of cell projection organization", "definition": "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. [GOC:mah]"}
{"concept_id": "C1622592", "aliases": ["intrinsic to plastid inner membrane"], "types": ["T026"], "canonical_name": "intrinsic component of plastid inner membrane", "definition": "The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622593", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell killing", "definition": "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism. [GOC:mah]"}
{"concept_id": "C1622594", "aliases": [], "types": ["T043"], "canonical_name": "regulation of termination of mating projection growth", "definition": "Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi. [PMID:14734532]"}
{"concept_id": "C1622596", "aliases": ["Rad17-RLC", "RFC (Rad17)", "Rad24p RFC-like complex", "Rad17 RFC-like complex location", "Rad17-RFC", "Rad24p RFC-like complex location"], "types": ["T026"], "canonical_name": "Rad17 RFC-like complex", "definition": "A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. [PMID:14614842]"}
{"concept_id": "C1622597", "aliases": ["integral to plastid outer membrane"], "types": ["T026"], "canonical_name": "integral component of plastid outer membrane", "definition": "The component of the plastid outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622598", "aliases": ["integral to chloroplast inner membrane"], "types": ["T026"], "canonical_name": "integral component of chloroplast inner membrane", "definition": "The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622599", "aliases": ["intrinsic to chloroplast outer membrane"], "types": ["T026"], "canonical_name": "intrinsic component of chloroplast outer membrane", "definition": "The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622600", "aliases": ["intrinsic to chloroplast inner membrane"], "types": ["T026"], "canonical_name": "intrinsic component of chloroplast inner membrane", "definition": "The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1622601", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid deamination, from side chain", "definition": "The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein. [GOC:mah]"}
{"concept_id": "C1622602", "aliases": ["Rdr1 complex location"], "types": ["T026"], "canonical_name": "Rdr1 complex"}
{"concept_id": "C1622604", "aliases": ["downregulation of protein modification", "down-regulation of protein modification", "down regulation of protein modification"], "types": ["T044"], "canonical_name": "negative regulation of protein modification process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. [GOC:mah, GOC:tb]"}
{"concept_id": "C1622605", "aliases": ["N-terminal acetyltransferase C complex", "NatC complex location", "N-terminal acetyltransferase C complex location"], "types": ["T026"], "canonical_name": "NatC complex", "definition": "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p. [PMID:12890471]"}
{"concept_id": "C1622606", "aliases": ["N-terminal acetyltransferase B complex location", "N-terminal acetyltransferase B complex", "NatB complex location"], "types": ["T026"], "canonical_name": "NatB complex", "definition": "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p. [PMID:12890471]"}
{"concept_id": "C1622607", "aliases": ["N-terminal acetyltransferase A complex", "N-terminal acetyltransferase A complex location", "NatA complex location"], "types": ["T026"], "canonical_name": "NatA complex", "definition": "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins. [PMID:12890471]"}
{"concept_id": "C1622609", "aliases": [], "types": ["T044"], "canonical_name": "hexon binding", "definition": "Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus. [GOC:mah, PMID:12915569]"}
{"concept_id": "C1622610", "aliases": ["BRCA1-BARD1 complex location"], "types": ["T026"], "canonical_name": "BRCA1-BARD1 complex", "definition": "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage. [PMID:12787778]"}
{"concept_id": "C1622611", "aliases": ["Hsk1-Dfp1 kinase complex location"], "types": ["T026"], "canonical_name": "Hsk1-Dfp1 kinase complex"}
{"concept_id": "C1622612", "aliases": ["Cdc7-Dbf4 complex location"], "types": ["T026"], "canonical_name": "Cdc7-Dbf4 complex"}
{"concept_id": "C1622613", "aliases": ["upregulation of mRNA 3'-end processing", "up-regulation of mRNA 3'-end processing", "up regulation of mRNA 3'-end processing"], "types": ["T045"], "canonical_name": "positive regulation of mRNA 3'-end processing", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. [GOC:mah]"}
{"concept_id": "C1622614", "aliases": [], "types": ["T044"], "canonical_name": "titin binding", "definition": "Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. [GOC:mah, PMID:10481174]"}
{"concept_id": "C1622615", "aliases": ["cullin complex", "cullin-RING ubiquitin ligase complex location", "cullin-RING ligase", "CRL complex", "CRL complex location", "cullin complex location"], "types": ["T026"], "canonical_name": "cullin-RING ubiquitin ligase complex", "definition": "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1622616", "aliases": ["ATPase-coupled glycine betaine transporter activity", "N-trimethylglycine-transporting ATPase activity", "ATP-dependent glycine betaine transporter activity", "glycine betaine-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type glycine betaine transporter activity", "definition": "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in). [GOC:mlg, RHEA:32783]"}
{"concept_id": "C1622618", "aliases": ["downregulation of mating type switching", "down-regulation of mating type switching", "down regulation of mating type switching"], "types": ["T043"], "canonical_name": "negative regulation of mating type switching", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching. [GOC:mah]"}
{"concept_id": "C1622619", "aliases": ["Cul4B-RING E3 ubiquitin ligase complex location", "cullin-RING ligase 4B"], "types": ["T026"], "canonical_name": "Cul4B-RING E3 ubiquitin ligase complex", "definition": "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits. [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1622620", "aliases": ["CRL7 complex location", "CDL7 complex location", "cullin-RING ligase 7", "SCF7 complex", "SCF7 complex location", "CDL7 complex", "Cul7-RING ubiquitin ligase complex location", "CRL7 complex"], "types": ["T026"], "canonical_name": "Cul7-RING ubiquitin ligase complex", "definition": "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein. [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1622624", "aliases": ["CRL5 complex", "CDL5 complex", "CDL5 complex location", "Cul5-RING ubiquitin ligase complex location", "cullin-RING ligase 5", "CRL5 complex location"], "types": ["T026"], "canonical_name": "Cul5-RING ubiquitin ligase complex", "definition": "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. [PMID:15571813, PMID:15688063]"}
{"concept_id": "C1622625", "aliases": ["VDC complex location"], "types": ["T026"], "canonical_name": "VDC complex"}
{"concept_id": "C1622628", "aliases": ["regulation of BDNF receptor activity", "regulation of brain-derived neurotrophic factor receptor activity"], "types": ["T044"], "canonical_name": "regulation of brain-derived neurotrophic factor-activated receptor activity", "definition": "Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity. [GOC:mah]"}
{"concept_id": "C1622630", "aliases": ["nuclear proteasome core complex location"], "types": ["T026"], "canonical_name": "nuclear proteasome core complex", "definition": "The core complex of a proteasome located in the nucleus of a cell. [GOC:mah]"}
{"concept_id": "C1622631", "aliases": ["prolyl 4-hydroxylase"], "types": ["T044"], "canonical_name": "prolyl 4-hydroxylase activity"}
{"concept_id": "C1622632", "aliases": ["down regulation of brain-derived neurotrophic factor receptor activity", "downregulation of brain-derived neurotrophic factor receptor activity", "negative regulation of BDNF receptor activity", "down-regulation of brain-derived neurotrophic factor receptor activity", "negative regulation of brain-derived neurotrophic factor receptor activity"], "types": ["T044"], "canonical_name": "negative regulation of brain-derived neurotrophic factor-activated receptor activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity. [GOC:mah]"}
{"concept_id": "C1622635", "aliases": ["intracellular signaling cascade involved in G1/S DNA damage checkpoint", "intracellular signal transduction involved in G1 DNA damage checkpoint", "mitotic cell cycle G1/S transition DNA damage checkpoint", "intracellular signaling pathway involved in G1 DNA damage checkpoint", "intracellular signaling chain involved in G1 DNA damage checkpoint", "intracellular signaling pathway involved in G1/S DNA damage checkpoint", "intracellular signaling cascade involved in G1 DNA damage checkpoint", "signal transmission via intracellular cascade involved in G1 DNA damage checkpoint", "intracellular signal transduction pathway involved in G1/S DNA damage checkpoint", "mitotic G1 DNA damage checkpoint", "intracellular signal transduction pathway involved in G1 DNA damage checkpoint", "intracellular signaling chain involved in G1/S DNA damage checkpoint", "signal transduction via intracellular signaling cascade involved in G1/S DNA damage checkpoint", "signal transduction via intracellular signaling cascade involved in G1 DNA damage checkpoint", "intracellular signal transduction involved in G1/S DNA damage checkpoint"], "types": ["T043"], "canonical_name": "mitotic G1 DNA damage checkpoint signaling", "definition": "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1622636", "aliases": ["regulation of IP3 receptor activity", "regulation of inositol-1,4,5-triphosphate receptor activity"], "types": ["T044"], "canonical_name": "regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity", "definition": "Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. [GOC:dph, GOC:mah, GOC:signaling]"}
{"concept_id": "C1622637", "aliases": [], "types": ["T043"], "canonical_name": "cell-substrate adhesion", "definition": "The attachment of a cell to the underlying substrate via adhesion molecules. [GOC:mah, GOC:pf]"}
{"concept_id": "C1622638", "aliases": ["5'-AMP-activated protein kinase complex location", "AMP-activated protein kinase complex location", "5'-AMP-activated protein kinase complex"], "types": ["T026"], "canonical_name": "AMP-activated protein kinase complex"}
{"concept_id": "C1622639", "aliases": ["down regulation of anthocyanin metabolic process", "downregulation of anthocyanin metabolic process", "negative regulation of anthocyanin metabolism", "down-regulation of anthocyanin metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of anthocyanin metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. [GOC:mah]"}
{"concept_id": "C1622640", "aliases": ["BDNF signalling pathway", "BDNF receptor signaling pathway", "brain-derived neurotrophic factor receptor signalling pathway"], "types": ["T044"], "canonical_name": "brain-derived neurotrophic factor receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands. [GOC:mah]"}
{"concept_id": "C1622642", "aliases": ["signal transduction involved in S-M checkpoint", "mitotic cell cycle DNA replication checkpoint", "S-M checkpoint", "S-M DNA replication checkpoint", "mitotic DNA replication checkpoint"], "types": ["T043"], "canonical_name": "mitotic DNA replication checkpoint signaling", "definition": "A signal transduction process that contributes to a mitotic DNA replication checkpoint. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1622646", "aliases": ["cytosolic proteasome complex location"], "types": ["T026"], "canonical_name": "cytosolic proteasome complex", "definition": "A proteasome complex found in the cytosol of a cell. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622648", "aliases": ["CBF3 complex location"], "types": ["T026"], "canonical_name": "CBF3 complex", "definition": "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p. [PMID:13679521, PMID:9407032]"}
{"concept_id": "C1622650", "aliases": [], "types": ["T026"], "canonical_name": "motile secondary cilium"}
{"concept_id": "C1622651", "aliases": [], "types": ["T026"], "canonical_name": "cytosolic proteasome regulatory particle", "definition": "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622653", "aliases": [], "types": ["T026"], "canonical_name": "centrosomal corona", "definition": "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin. [GOC:kp, GOC:mah]"}
{"concept_id": "C1622655", "aliases": ["PMT family mannosyltransferase complex location"], "types": ["T026"], "canonical_name": "PMT family mannosyltransferase complex"}
{"concept_id": "C1622656", "aliases": ["cell wall glycoprotein synthesis", "cell wall glycoprotein biosynthesis", "cell wall glycoprotein anabolism", "cell wall glycoprotein formation"], "types": ["T043"], "canonical_name": "cell wall glycoprotein biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues. [GOC:mah]"}
{"concept_id": "C1622657", "aliases": ["SUMO activating enzyme complex", "SUMO E1 activator enzyme complex", "SAE", "SUMO E1 activator enzyme complex location"], "types": ["T026"], "definition": "A conserved heterodimeric complex with SUMO activating enzyme activity. [PMID:15601841]", "canonical_name": "SUMO activating enzyme complex location"}
{"concept_id": "C1622662", "aliases": ["rDNA spacer replication fork barrier binding", "RFB binding"], "types": ["T045"], "canonical_name": "replication fork barrier binding", "definition": "Binding to replication fork barriers, sites that inhibit the progress of replication forks. [GOC:mah]"}
{"concept_id": "C1622663", "aliases": ["opioid receptor, adenylate cyclase inhibiting pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-inhibiting opioid receptor signaling pathway", "definition": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C1622666", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin conjugating enzyme binding", "definition": "Binding to a ubiquitin conjugating enzyme, any of the E2 proteins. [GOC:vp]"}
{"concept_id": "C1622667", "aliases": ["cleavage of plasminogen to plasmin"], "types": ["T044"], "canonical_name": "plasminogen activation", "definition": "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide. [PMID:9548733]"}
{"concept_id": "C1622670", "aliases": ["down-regulation of heat generation", "down regulation of heat generation", "downregulation of heat generation"], "types": ["T040"], "canonical_name": "negative regulation of heat generation", "definition": "Any process that stops, prevents, or reduces the rate or extent of heat generation. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1622671", "aliases": ["downregulation of myelination", "down-regulation of myelination", "down regulation of myelination"], "types": ["T043"], "canonical_name": "negative regulation of myelination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah]"}
{"concept_id": "C1622672", "aliases": ["NADH:plastoquinone reductase activity"], "types": ["T044"], "canonical_name": "NADH dehydrogenase (plastoquinone) activity", "definition": "Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol. [EC:1.6.99.6, GOC:mah]"}
{"concept_id": "C1622673", "aliases": ["G-gamma protein subunit binding"], "types": ["T044"], "canonical_name": "G-protein gamma-subunit binding", "definition": "Binding to a G-protein gamma subunit. [GOC:mah]"}
{"concept_id": "C1622674", "aliases": ["DNA glycosylase/AP-lyase", "DNA glycosylase/beta-lyase"], "types": ["T045"], "canonical_name": "bifunctional DNA glycosylase"}
{"concept_id": "C1622675", "aliases": [], "types": ["T044"], "canonical_name": "thiamin pyrophosphate porter activity"}
{"concept_id": "C1622676", "aliases": [], "types": ["T044"], "canonical_name": "calcium efflux ATPase"}
{"concept_id": "C1622677", "aliases": [], "types": ["T044"], "canonical_name": "dynein"}
{"concept_id": "C1622679", "aliases": [], "types": ["T044"], "canonical_name": "SNF1A/AMP-activated protein kinase activity"}
{"concept_id": "C1622680", "aliases": [], "types": ["T046"], "canonical_name": "detoxification response"}
{"concept_id": "C1622682", "aliases": ["heme chloroperoxidase activity"], "types": ["T044"], "canonical_name": "haem chloroperoxidase activity"}
{"concept_id": "C1622683", "aliases": [], "types": ["T044"], "canonical_name": "oxygenase"}
{"concept_id": "C1622684", "aliases": ["ergocalciferol biosynthesis"], "types": ["T044"], "canonical_name": "ergocalciferol biosynthesis"}
{"concept_id": "C1622685", "aliases": ["TNF receptor activity, type I"], "types": ["T044"], "canonical_name": "tumor necrosis factor receptor activity, type I"}
{"concept_id": "C1622686", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome b566"}
{"concept_id": "C1622689", "aliases": ["type 1 Burkitt's lymphoma receptor binding"], "types": ["T044"], "canonical_name": "CXCR5 chemokine receptor binding", "definition": "Binding to a CXCR5 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622690", "aliases": [], "types": ["T044"], "canonical_name": "endothelin B receptor binding", "definition": "Binding to an endothelin B receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622691", "aliases": ["bonzo receptor binding", "STRL33 receptor binding"], "types": ["T044"], "canonical_name": "CXCR6 chemokine receptor binding", "definition": "Binding to a CXCR6 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622693", "aliases": [], "types": ["T044"], "canonical_name": "C5L2 anaphylatoxin chemotactic receptor ligand"}
{"concept_id": "C1622694", "aliases": [], "types": ["T044"], "canonical_name": "hemoglobin alpha binding", "definition": "Binding to a hemoglobin alpha chain. [GOC:mah]"}
{"concept_id": "C1622697", "aliases": [], "types": ["T044"], "canonical_name": "motilin receptor ligand"}
{"concept_id": "C1622698", "aliases": ["neurokinin-1 receptor binding"], "types": ["T044"], "canonical_name": "substance P receptor binding", "definition": "Binding to a substance P receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622699", "aliases": [], "types": ["T044"], "canonical_name": "type 1 parathyroid hormone receptor binding", "definition": "Binding to a type 1 parathyroid hormone receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622700", "aliases": [], "types": ["T044"], "canonical_name": "delta-type opioid receptor binding", "definition": "Binding to a delta-type opioid receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622701", "aliases": [], "types": ["T044"], "canonical_name": "M2 muscarinic acetylcholine receptor binding"}
{"concept_id": "C1622702", "aliases": [], "types": ["T044"], "canonical_name": "CCR4 chemokine receptor ligand"}
{"concept_id": "C1622703", "aliases": [], "types": ["T044"], "canonical_name": "CCR10 chemokine receptor ligand"}
{"concept_id": "C1622704", "aliases": [], "types": ["T044"], "canonical_name": "type 2 neuropeptide Y receptor binding", "definition": "Binding to a type 2 neuropeptide Y receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622705", "aliases": [], "types": ["T044"], "canonical_name": "platelet activating factor receptor binding", "definition": "Binding to a platelet activating factor receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622706", "aliases": [], "types": ["T044"], "canonical_name": "prolactin-releasing peptide receptor ligand"}
{"concept_id": "C1622707", "aliases": [], "types": ["T044"], "canonical_name": "olfactory receptor ligand"}
{"concept_id": "C1622708", "aliases": [], "types": ["T044"], "canonical_name": "V2 vasopressin receptor binding", "definition": "Binding to a V2 vasopressin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622709", "aliases": [], "types": ["T044"], "canonical_name": "type 4 somatostatin receptor ligand"}
{"concept_id": "C1622710", "aliases": [], "types": ["T044"], "canonical_name": "type 2 vasoactive intestinal polypeptide receptor ligand"}
{"concept_id": "C1622711", "aliases": ["prostanoid FP receptor binding"], "types": ["T044"], "canonical_name": "prostaglandin F2-alpha receptor binding", "definition": "Binding to a prostaglandin F2-alpha receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622712", "aliases": [], "types": ["T044"], "canonical_name": "urotensin receptor ligand"}
{"concept_id": "C1622714", "aliases": [], "types": ["T044"], "canonical_name": "attractant"}
{"concept_id": "C1622715", "aliases": ["D1B dopamine receptor binding"], "types": ["T044"], "canonical_name": "D5 dopamine receptor binding", "definition": "Binding to a D5 dopamine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622716", "aliases": ["LPA3 receptor binding"], "types": ["T044"], "canonical_name": "Edg-7 lysophosphatidic acid receptor binding", "definition": "Binding to an Edg-7 lysophosphatidic acid receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622717", "aliases": [], "types": ["T044"], "canonical_name": "type 6 metabotropic glutamate receptor binding", "definition": "Binding to a type 6 metabotropic glutamate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622718", "aliases": ["lipid particle transport along microtubule", "lipid body transport along microtubule", "adiposome transport along microtubule"], "types": ["T043"], "canonical_name": "lipid droplet transport along microtubule", "definition": "The directed movement of a lipid droplet along a microtubule, mediated by motor proteins. [PMID:9491895]"}
{"concept_id": "C1622719", "aliases": [], "types": ["T044"], "canonical_name": "V1A vasopressin receptor ligand"}
{"concept_id": "C1622720", "aliases": [], "types": ["T044"], "canonical_name": "type 1 member 2 taste receptor ligand"}
{"concept_id": "C1622721", "aliases": [], "types": ["T044"], "canonical_name": "V1B vasopressin receptor ligand"}
{"concept_id": "C1622722", "aliases": [], "types": ["T044"], "canonical_name": "type 3 proteinase activated receptor ligand"}
{"concept_id": "C1622724", "aliases": ["lymphotactin receptor binding"], "types": ["T044"], "canonical_name": "XCR1 chemokine receptor binding", "definition": "Binding to a XCR1 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622725", "aliases": [], "types": ["T044"], "canonical_name": "type 3 metabotropic glutamate receptor ligand"}
{"concept_id": "C1622726", "aliases": [], "types": ["T044"], "canonical_name": "type 5 metabotropic glutamate receptor binding", "definition": "Binding to a type 5 metabotropic glutamate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622727", "aliases": [], "types": ["T043"], "canonical_name": "pyridoxal transport", "definition": "The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. [GOC:mah]"}
{"concept_id": "C1622729", "aliases": [], "types": ["T026"], "canonical_name": "thylakoid lumen", "definition": "The volume enclosed by a thylakoid membrane. [GOC:mah, GOC:pz]"}
{"concept_id": "C1622730", "aliases": ["regulation of protein amino acid autophosphorylation"], "types": ["T044"], "canonical_name": "regulation of protein autophosphorylation", "definition": "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. [GOC:mah]"}
{"concept_id": "C1622731", "aliases": ["response to corticosteroid stimulus"], "types": ["T043"], "canonical_name": "response to corticosteroid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. [GOC:mah, PMID:11027914]"}
{"concept_id": "C1622732", "aliases": ["plasma membrane thylakoid lumen"], "types": ["T026"], "canonical_name": "plasma membrane-derived thylakoid lumen", "definition": "The volume enclosed by a plasma membrane-derived thylakoid. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1622733", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic metaplasticity", "definition": "A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. [GOC:mah, PMID:8658594]"}
{"concept_id": "C1622735", "aliases": [], "types": ["T044"], "canonical_name": "H2 histamine receptor binding", "definition": "Binding to a H2 histamine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622736", "aliases": [], "types": ["T044"], "canonical_name": "type 2 cysteinyl leukotriene receptor ligand"}
{"concept_id": "C1622737", "aliases": [], "types": ["T044"], "canonical_name": "type A cholecystokinin receptor ligand"}
{"concept_id": "C1622738", "aliases": ["fractalkine receptor binding"], "types": ["T044"], "canonical_name": "CX3C chemokine receptor binding", "definition": "Binding to a CX3C chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622739", "aliases": [], "types": ["T044"], "canonical_name": "D3 dopamine receptor binding", "definition": "Binding to a D3 dopamine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622740", "aliases": ["positive regulation of protein amino acid autophosphorylation", "up regulation of protein amino acid autophosphorylation", "upregulation of protein amino acid autophosphorylation", "up-regulation of protein amino acid autophosphorylation"], "types": ["T044"], "canonical_name": "positive regulation of protein autophosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. [GOC:mah]"}
{"concept_id": "C1622741", "aliases": ["locomotion during locomotory behaviour"], "types": ["T038"], "canonical_name": "locomotion involved in locomotory behavior", "definition": "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. [GOC:mah]"}
{"concept_id": "C1622742", "aliases": ["IL-28"], "types": ["T044"], "canonical_name": "interleukin-28 receptor binding", "definition": "Binding to an interleukin-28 receptor. [GOC:rph]"}
{"concept_id": "C1622743", "aliases": ["membrane-enclosed vesicle"], "types": ["T026"], "canonical_name": "membrane-bounded vesicle"}
{"concept_id": "C1622744", "aliases": [], "types": ["T044"], "canonical_name": "mineralocorticoid receptor binding"}
{"concept_id": "C1622745", "aliases": ["bombesin receptor signalling pathway"], "types": ["T044"], "canonical_name": "bombesin receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by a bombesin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah]"}
{"concept_id": "C1622746", "aliases": ["chromoplast envelope lumen"], "types": ["T026"], "canonical_name": "chromoplast intermembrane space", "definition": "The region between the inner and outer lipid bilayers of a chromoplast envelope. [GOC:mah]"}
{"concept_id": "C1622747", "aliases": ["down regulation of glucocorticoid metabolic process", "negative regulation of glucocorticoid metabolism", "down-regulation of glucocorticoid metabolic process", "downregulation of glucocorticoid metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of glucocorticoid metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. [GOC:mah]"}
{"concept_id": "C1622748", "aliases": [], "types": ["T043"], "canonical_name": "vitamin B6 transport", "definition": "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1622749", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxine transporter activity"}
{"concept_id": "C1622752", "aliases": ["metastin receptor binding", "G-protein coupled receptor 54 binding", "hOT7T175 receptor binding", "hypogonadotropin-1 receptor binding", "KiSS-1 receptor binding"], "types": ["T044"], "canonical_name": "kisspeptin receptor binding", "definition": "Binding to a kisspeptin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622753", "aliases": ["type 1 growth hormone secretagogue GH-releasing peptide receptor binding"], "types": ["T044"], "canonical_name": "ghrelin receptor binding", "definition": "Binding to a ghrelin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622754", "aliases": [], "types": ["T044"], "canonical_name": "gastric inhibitory polypeptide receptor binding", "definition": "Binding to a gastric inhibitory polypeptide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622755", "aliases": ["5-hydroxytryptamine 1E receptor binding"], "types": ["T044"], "canonical_name": "type 1E serotonin receptor binding", "definition": "Binding to a type 1E serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622756", "aliases": [], "types": ["T044"], "canonical_name": "P2Y11 nucleotide receptor binding", "definition": "Binding to a P2Y11 nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622757", "aliases": ["5-hydroxytryptamine 1B receptor binding"], "types": ["T044"], "canonical_name": "type 1B serotonin receptor binding", "definition": "Binding to a type 1B serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622758", "aliases": [], "types": ["T044"], "canonical_name": "melanin-concentrating hormone receptor binding", "definition": "Binding to a melanin-concentrating hormone receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622759", "aliases": [], "types": ["T044"], "canonical_name": "P2Y4 nucleotide receptor binding", "definition": "Binding to a P2Y4 nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1622760", "aliases": [], "types": ["T044"], "canonical_name": "P2Y6 nucleotide receptor ligand"}
{"concept_id": "C1622761", "aliases": [], "types": ["T044"], "canonical_name": "P2Y8 nucleotide receptor ligand"}
{"concept_id": "C1622762", "aliases": [], "types": ["T042"], "canonical_name": "hair cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a hair cell. [GOC:bf]"}
{"concept_id": "C1622763", "aliases": [], "types": ["T043"], "canonical_name": "notum cell fate specification", "definition": "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment. [PMID:10860999]"}
{"concept_id": "C1622823", "aliases": ["downregulation of eosinophil degranulation", "down regulation of eosinophil degranulation", "down-regulation of eosinophil degranulation", "negative regulation of eosinophil granule exocytosis"], "types": ["T043"], "canonical_name": "negative regulation of eosinophil degranulation", "definition": "Any process that stops, prevents, or reduces the rate of eosinophil degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622824", "aliases": ["regulation of neutrophil granule exocytosis"], "types": ["T043"], "canonical_name": "regulation of neutrophil degranulation", "definition": "Any process that modulates the frequency, rate, or extent of neutrophil degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622844", "aliases": ["eosinophil granule exocytosis"], "types": ["T043"], "canonical_name": "eosinophil degranulation", "definition": "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil. [ISBN:0781735149]"}
{"concept_id": "C1622853", "aliases": ["down-regulation of neutrophil degranulation", "down regulation of neutrophil degranulation", "negative regulation of neutrophil granule exocytosis", "downregulation of neutrophil degranulation"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil degranulation", "definition": "Any process that stops, prevents, or reduces the rate of neutrophil degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622855", "aliases": ["regulation of NK cell granule exocytosis", "regulation of NK cell degranulation", "regulation of natural killer cell granule exocytosis"], "types": ["T043"], "canonical_name": "regulation of natural killer cell degranulation", "definition": "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622856", "aliases": [], "types": ["T045"], "canonical_name": "ribosomal protein"}
{"concept_id": "C1622857", "aliases": ["pullulan alpha-1,6-glucanohydrolase activity", "pullulanase activity", "amylopectin 6-glucanohydrolase activity", "pullulan 6-glucanohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen. [EC:3.2.1.41]", "canonical_name": "alpha-dextrin endo-1,6-alpha-glucosidase activity"}
{"concept_id": "C1622858", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis signaling"}
{"concept_id": "C1622860", "aliases": [], "types": ["T043"], "canonical_name": "dictyosome vesicle coat depolymerization"}
{"concept_id": "C1622861", "aliases": [], "types": ["T043"], "canonical_name": "dictyosome vesicle docking to target membrane"}
{"concept_id": "C1622876", "aliases": [], "types": ["T044"], "canonical_name": "anion ABC transporter"}
{"concept_id": "C1622877", "aliases": ["up regulation of mast cell degranulation", "up-regulation of mast cell degranulation", "upregulation of mast cell degranulation", "positive regulation of mast cell granule exocytosis"], "types": ["T043"], "canonical_name": "positive regulation of mast cell degranulation", "definition": "Any process that activates or increases the frequency, rate or extent of mast cell degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622879", "aliases": ["regulation of leucocyte degranulation", "regulation of immune cell degranulation", "regulation of leukocyte granule exocytosis", "regulation of immune cell granule exocytosis"], "types": ["T043"], "canonical_name": "regulation of leukocyte degranulation", "definition": "Any process that modulates the frequency, rate, or extent of leukocyte degranulation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1622880", "aliases": [], "types": ["T043"], "canonical_name": "eosinophil activation", "definition": "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1622883", "aliases": ["negative regulation of mast cell granule exocytosis", "downregulation of mast cell degranulation", "down-regulation of mast cell degranulation", "down regulation of mast cell degranulation"], "types": ["T043"], "canonical_name": "negative regulation of mast cell degranulation", "definition": "Any process that stops, prevents, or reduces the rate of mast cell degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622886", "aliases": ["sporangia development", "sporangium development"], "types": ["T043"], "canonical_name": "sporangium development", "definition": "The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores. [GOC:jl, Wikipedia:Sporagium]"}
{"concept_id": "C1622887", "aliases": [], "types": ["T044"], "canonical_name": "CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase"}
{"concept_id": "C1622888", "aliases": ["regulation of memory T lymphocyte differentiation", "regulation of memory T-lymphocyte differentiation", "regulation of memory T-cell differentiation"], "types": ["T043"], "canonical_name": "regulation of memory T cell differentiation", "definition": "Any process that modulates the frequency, rate, or extent of memory T cell differentiation. [ISBN:0781735149]"}
{"concept_id": "C1622890", "aliases": ["site-specific telomere resolvase activity", "ResT"], "types": ["T044"], "definition": "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases. [GOC:jl, PMID:11804598]", "canonical_name": "TelN"}
{"concept_id": "C1622891", "aliases": ["mast cell granule exocytosis"], "types": ["T043"], "definition": "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. [ISBN:0781735149]", "canonical_name": "mast cell degranulation"}
{"concept_id": "C1622894", "aliases": ["regulation of mast cell granule exocytosis"], "types": ["T043"], "canonical_name": "regulation of mast cell degranulation", "definition": "Any process that modulates the frequency, rate, or extent of mast cell degranulation. [ISBN:0781735149]"}
{"concept_id": "C1622895", "aliases": [], "types": ["T044"], "canonical_name": "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity", "definition": "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol. [GOC:jl, PMID:10960477, RHEA:25690]"}
{"concept_id": "C1622898", "aliases": ["CRH secretion", "CRF secretion", "corticotropin-releasing factor secretion"], "types": ["T042"], "canonical_name": "corticotropin-releasing hormone secretion", "definition": "The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle. [GOC:go_curators, PMID:11027914]"}
{"concept_id": "C1622906", "aliases": ["glucocorticoid mediated signalling"], "types": ["T044"], "canonical_name": "glucocorticoid mediated signaling pathway", "definition": "The series of molecular signals mediated by the detection of a glucocorticoid hormone. [PMID:15240347]"}
{"concept_id": "C1622911", "aliases": [], "types": ["T043"], "definition": "The phase of cell nucleus division following METAPHASE, in which the CHROMATIDS separate and migrate to opposite poles of the spindle.", "canonical_name": "anaphase"}
{"concept_id": "C1622917", "aliases": ["spindle checkpoint signaling", "spindle checkpoint"], "types": ["T043"], "definition": "A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle. [GOC:mtg_cell_cycle]", "canonical_name": "signal transduction involved in spindle checkpoint"}
{"concept_id": "C1622918", "aliases": ["alpha-1,6-mannosyltransferase complex", "mannan polymerase complex location", "alpha-1,6-mannosyltransferase complex location"], "types": ["T026"], "canonical_name": "mannan polymerase complex", "definition": "A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins. [GOC:mcc, PMID:10037752, PMID:11095735, PMID:18083825]"}
{"concept_id": "C1622922", "aliases": [], "types": ["T045"], "canonical_name": "A/G-specific adenine DNA glycosylase activity"}
{"concept_id": "C1622923", "aliases": [], "types": ["T042"], "definition": "Replacement ossification wherein bone tissue replaces cartilage. [GO_REF:0000034, ISBN:0878932437]", "canonical_name": "endochondral ossification"}
{"concept_id": "C1622924", "aliases": [], "types": ["T026"], "canonical_name": "female pronucleus", "definition": "The pronucleus originating from the ovum that is being fertilized. [GOC:hjd, ISBN:0198506732]"}
{"concept_id": "C1622925", "aliases": ["up-regulation of neurotransmitter secretion", "upregulation of neurotransmitter secretion", "up regulation of neurotransmitter secretion"], "types": ["T043"], "canonical_name": "positive regulation of neurotransmitter secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. [GOC:hjd]"}
{"concept_id": "C1622926", "aliases": [], "types": ["T026"], "canonical_name": "male pronucleus", "definition": "The pronucleus originating from the spermatozoa that was involved in fertilization. [GOC:hjd, ISBN:0198506732]"}
{"concept_id": "C1622927", "aliases": ["cardiac looping"], "types": ["T042"], "canonical_name": "heart looping", "definition": "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. [GOC:dph, PMID:12094232]"}
{"concept_id": "C1622929", "aliases": ["hormonal regulation of blood pressure", "blood pressure regulation by hormone"], "types": ["T038"], "canonical_name": "regulation of systemic arterial blood pressure by hormone", "definition": "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. [GOC:mtg_cardio, ISBN:0721643949]"}
{"concept_id": "C1622930", "aliases": ["angiotensin mediated vasoconstriction during blood pressure regulation", "angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure"], "types": ["T042"], "canonical_name": "angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure", "definition": "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream. [GOC:mtg_cardio, GOC:pr, ISBN:0721643949]"}
{"concept_id": "C1622931", "aliases": ["noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure", "norepinephrine-epinephrine vasoconstriction during blood pressure regulation"], "types": ["T042"], "canonical_name": "norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure", "definition": "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure. [GOC:mtg_cardio, ISBN:0721643949]"}
{"concept_id": "C1622934", "aliases": [], "types": ["T039"], "canonical_name": "increased inotropy by epinephrine-norepinephrine"}
{"concept_id": "C1622935", "aliases": [], "types": ["T040"], "canonical_name": "baroreceptor response to decreased systemic arterial blood pressure", "definition": "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels. [GOC:dph, GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]"}
{"concept_id": "C1622937", "aliases": [], "types": ["T040"], "canonical_name": "atrial control of blood pressure"}
{"concept_id": "C1622938", "aliases": ["excitation of vasomotor center by baroreceptor signalling"], "types": ["T040"], "canonical_name": "excitation of vasomotor center by baroreceptor signaling", "definition": "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure. [GOC:dph]"}
{"concept_id": "C1622940", "aliases": [], "types": ["T039"], "canonical_name": "renin-angiotensin regulation of aldosterone production", "definition": "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone. [ISBN:0721643949]"}
{"concept_id": "C1622942", "aliases": [], "types": ["T044"], "canonical_name": "O-glycoside mannosyltransferase"}
{"concept_id": "C1622944", "aliases": [], "types": ["T040"], "canonical_name": "response to dietary excess", "definition": "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. [GOC:pg, GOC:pr, PMID:12161655]"}
{"concept_id": "C1622945", "aliases": [], "types": ["T044"], "canonical_name": "invertase activity"}
{"concept_id": "C1622947", "aliases": [], "types": ["T044"], "canonical_name": "invertin activity"}
{"concept_id": "C1622949", "aliases": [], "types": ["T040"], "canonical_name": "brain renin-angiotensin system", "definition": "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system. [PMID:2909574]"}
{"concept_id": "C1622951", "aliases": ["PCNA loading complex activity"], "types": ["T045"], "canonical_name": "PCNA loading activity"}
{"concept_id": "C1622952", "aliases": ["desensitisation of G-protein coupled receptor protein signalling pathway", "desensitization of G-protein coupled receptor protein signaling pathway"], "types": ["T043"], "canonical_name": "desensitization of G protein-coupled receptor signaling pathway", "definition": "The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway. [PMID:8396717]"}
{"concept_id": "C1622954", "aliases": ["ribosomal RNA location"], "types": ["T026"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:mah]", "canonical_name": "ribosomal RNA"}
{"concept_id": "C1622966", "aliases": ["CFII complex location"], "types": ["T026"], "canonical_name": "CFII complex"}
{"concept_id": "C1622967", "aliases": ["cell periphery"], "types": ["T026"], "canonical_name": "cell periphery", "definition": "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. [GOC:mah]"}
{"concept_id": "C1622976", "aliases": ["stress-activated protein kinase cascade", "SAPK cascade"], "types": ["T044"], "canonical_name": "SAPK cascade"}
{"concept_id": "C1622977", "aliases": [], "types": ["T045"], "canonical_name": "chromosome transmission"}
{"concept_id": "C1622979", "aliases": [], "types": ["T040"], "canonical_name": "egg laying"}
{"concept_id": "C1622983", "aliases": [], "types": ["T044"], "canonical_name": "DNA adenine methylase"}
{"concept_id": "C1622984", "aliases": ["mRNA biosynthesis"], "types": ["T045"], "canonical_name": "mRNA synthesis"}
{"concept_id": "C1622985", "aliases": ["tRNA biosynthesis"], "types": ["T045"], "canonical_name": "tRNA synthesis"}
{"concept_id": "C1622988", "aliases": [], "types": ["T044"], "canonical_name": "photosynthetic NADP+ reduction", "definition": "An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions. [GOC:jid, ISBN:0716746840, ISBN:0816017360]"}
{"concept_id": "C1622990", "aliases": [], "types": ["T045"], "canonical_name": "pre-mRNA splicing"}
{"concept_id": "C1622992", "aliases": [], "types": ["T042"], "canonical_name": "animal organ morphogenesis", "definition": "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]"}
{"concept_id": "C1622997", "aliases": [], "types": ["T040"], "canonical_name": "nectary development", "definition": "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure. [GOC:lr]"}
{"concept_id": "C1622998", "aliases": [], "types": ["T044"], "canonical_name": "NADH dehydrogenase complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. [GOC:sm]"}
{"concept_id": "C1622999", "aliases": ["UDP-rhamnose formation", "UDP-rhamnose biosynthesis", "UDP-rhamnose anabolism", "UDP-rhamnose synthesis"], "types": ["T044"], "canonical_name": "UDP-rhamnose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate. [PMID:15134748]"}
{"concept_id": "C1623001", "aliases": ["heavy metal ion porter activity"], "types": ["T044"], "canonical_name": "heavy metal ion porter activity", "definition": "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane. [GOC:ai]"}
{"concept_id": "C1623002", "aliases": [], "types": ["T044"], "canonical_name": "auxin homeostasis", "definition": "A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation. [PMID:22504182]"}
{"concept_id": "C1623005", "aliases": [], "types": ["T039"], "canonical_name": "response to low fluence red light stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec. [GOC:mtg_far_red, GOC:sm]"}
{"concept_id": "C1623006", "aliases": ["sulfate ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type sulfate transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). [RHEA:10192]"}
{"concept_id": "C1623008", "aliases": ["photosynthetic water oxidation"], "types": ["T044"], "canonical_name": "oxygen evolving activity", "definition": "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle. [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862]"}
{"concept_id": "C1623009", "aliases": ["phosphate ion detection"], "types": ["T043"], "canonical_name": "detection of phosphate ion", "definition": "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal. [GOC:sm]"}
{"concept_id": "C1623010", "aliases": [], "types": ["T044"], "canonical_name": "alternative respiration", "definition": "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa. [ISBN:0943088399]"}
{"concept_id": "C1623011", "aliases": ["response to organic nitrogen"], "types": ["T043"], "canonical_name": "response to organonitrogen compound", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. [PMID:9869419]"}
{"concept_id": "C1623012", "aliases": [], "types": ["T040"], "canonical_name": "response to proline", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus. [GOC:sm]"}
{"concept_id": "C1623013", "aliases": [], "types": ["T044"], "canonical_name": "ent-kaurene oxidase activity", "definition": "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol. [MetaCyc:1.14.13.78-RXN]"}
{"concept_id": "C1623014", "aliases": [], "types": ["T043"], "canonical_name": "vascular transport", "definition": "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane. [GOC:sm]"}
{"concept_id": "C1623015", "aliases": [], "types": ["T044"], "canonical_name": "diterpene catabolism"}
{"concept_id": "C1623016", "aliases": [], "types": ["T044"], "canonical_name": "linoleic desaturase activity"}
{"concept_id": "C1623017", "aliases": [], "types": ["T044"], "canonical_name": "delta(6)-fatty acyl-CoA desaturase activity"}
{"concept_id": "C1623019", "aliases": [], "types": ["T026"], "canonical_name": "conventional myosin"}
{"concept_id": "C1623024", "aliases": ["protein amino acid C-linked glycosylation"], "types": ["T044"], "canonical_name": "protein C-linked glycosylation", "definition": "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom. [GOC:pr, PMID:7947762, RESID:AA0217]"}
{"concept_id": "C1623026", "aliases": ["protein amino acid N-linked glycosylation via tryptophan"], "types": ["T044"], "canonical_name": "protein N-linked glycosylation via tryptophan", "definition": "The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue. [RESID:AA0156]"}
{"concept_id": "C1623027", "aliases": ["protein amino acid O-linked glycosylation via serine"], "types": ["T044"], "canonical_name": "protein O-linked glycosylation via serine", "definition": "The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine. [RESID:AA0154]"}
{"concept_id": "C1623028", "aliases": ["protein amino acid N-linked glycosylation via asparagine"], "types": ["T044"], "canonical_name": "protein N-linked glycosylation via asparagine", "definition": "The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]"}
{"concept_id": "C1623029", "aliases": ["protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan", "protein amino acid C-linked mannosylation"], "types": ["T044"], "canonical_name": "protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan", "definition": "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring. [PMID:7947762, PMID:9450955, RESID:AA0217]"}
{"concept_id": "C1623032", "aliases": [], "types": ["T040"], "canonical_name": "sensory perception of slow pain", "definition": "The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction. [http://www.people.vcu.edu/~mikuleck/ssspain/, http://www.spine-health.com/]"}
{"concept_id": "C1623033", "aliases": [], "types": ["T044"], "canonical_name": "glyoxalase system"}
{"concept_id": "C1623036", "aliases": ["cellular protein degradation", "protein catabolic process", "protein breakdown", "cellular protein catabolism", "cellular protein catabolic process", "cellular protein breakdown", "protein degradation"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]", "canonical_name": "protein catabolism"}
{"concept_id": "C1623042", "aliases": [], "types": ["T044"], "canonical_name": "cation ABC transporter"}
{"concept_id": "C1623043", "aliases": [], "types": ["T026"], "canonical_name": "organelle inner membrane", "definition": "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. [GOC:mah]"}
{"concept_id": "C1623047", "aliases": [], "types": ["T042"], "definition": "The regrowth of lost or destroyed tissues. [GOC:curators]", "canonical_name": "tissue regeneration"}
{"concept_id": "C1623053", "aliases": ["platelet alpha-granule lumen"], "types": ["T026"], "canonical_name": "platelet alpha granule lumen", "definition": "The volume enclosed by the membrane of the platelet alpha granule. [GOC:mah, PMID:8467233]"}
{"concept_id": "C1623054", "aliases": ["post-embryonic camera-style eye development"], "types": ["T042"], "canonical_name": "post-embryonic camera-type eye development", "definition": "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1623055", "aliases": [], "types": ["T026"], "canonical_name": "platelet dense tubular network lumen", "definition": "The volume enclosed by the membranes of the platelet dense tubular network. [GOC:mah, PMID:1322202]"}
{"concept_id": "C1623057", "aliases": ["mRNA 3' end processing"], "types": ["T045"], "canonical_name": "mRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of an mRNA molecule. [GOC:mah]"}
{"concept_id": "C1623058", "aliases": ["rRNA 3' end processing"], "types": ["T045"], "canonical_name": "rRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of an rRNA molecule. [GOC:mah]"}
{"concept_id": "C1623060", "aliases": ["cytoplasmic microtubule organization and biogenesis", "cytoplasmic microtubule organisation"], "types": ["T043"], "canonical_name": "cytoplasmic microtubule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. [GOC:mah]"}
{"concept_id": "C1623063", "aliases": [], "types": ["T044"], "canonical_name": "rhizobactin 1021 biosynthetic process, peptide formation"}
{"concept_id": "C1623064", "aliases": [], "types": ["T044"], "canonical_name": "enterobactin biosynthetic process, peptide modification"}
{"concept_id": "C1623065", "aliases": [], "types": ["T044"], "canonical_name": "vibriobactin biosynthetic process, peptide formation"}
{"concept_id": "C1623066", "aliases": [], "types": ["T043"], "canonical_name": "induction of conjugation upon carbon starvation", "definition": "The process in which a cell initiates conjugation with cellular fusion upon carbon starvation. [GOC:mah]"}
{"concept_id": "C1623068", "aliases": ["histone methylase activity (H3-K79 specific)", "histone lysine N-methyltransferase activity (H3-K79 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-K79 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein. [GOC:mah, PMID:15371351]"}
{"concept_id": "C1623069", "aliases": ["sorophore development"], "types": ["T040"], "canonical_name": "sorocarp stalk development", "definition": "The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum. [GOC:mtg_sensu, ISBN:0521583640, PMID:4338436]"}
{"concept_id": "C1623070", "aliases": [], "types": ["T044"], "canonical_name": "vibriobactin biosynthetic process, peptide modification"}
{"concept_id": "C1623071", "aliases": [], "types": ["T044"], "canonical_name": "ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C1623072", "aliases": ["integral to vacuolar membrane"], "types": ["T026"], "canonical_name": "integral component of vacuolar membrane", "definition": "The component of the vacuolar membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. [GOC:dos, GOC:mah]"}
{"concept_id": "C1623073", "aliases": ["phosphatidylinositol degradation", "PtdIns catabolism", "PtdIns catabolic process", "phosphatidylinositol catabolism", "phosphatidylinositol breakdown"], "types": ["T044"], "canonical_name": "phosphatidylinositol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [GOC:mah]"}
{"concept_id": "C1623074", "aliases": [], "types": ["T044"], "canonical_name": "ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C1623076", "aliases": [], "types": ["T045"], "canonical_name": "rRNA methylation", "definition": "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. [GOC:mah]"}
{"concept_id": "C1623077", "aliases": ["metallo-sulphur cluster assembly", "metal-sulfur cluster assembly"], "types": ["T044"], "canonical_name": "metallo-sulfur cluster assembly", "definition": "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. [GOC:jl, GOC:mah, GOC:pde, GOC:vw]"}
{"concept_id": "C1623078", "aliases": ["sulphur incorporation into metallo-sulphur cluster"], "types": ["T044"], "canonical_name": "sulfur incorporation into metallo-sulfur cluster", "definition": "The incorporation of exogenous sulfur into a metallo-sulfur cluster. [GOC:mah]"}
{"concept_id": "C1623080", "aliases": [], "types": ["T044"], "canonical_name": "pyochelin biosynthetic process, peptide modification"}
{"concept_id": "C1623082", "aliases": ["arabinan degradation", "arabinan breakdown", "arabinan catabolism"], "types": ["T044"], "canonical_name": "arabinan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues. [GOC:mlg, ISBN:0198506732]"}
{"concept_id": "C1623085", "aliases": [], "types": ["T044"], "canonical_name": "enterobactin biosynthetic process, peptide formation"}
{"concept_id": "C1623086", "aliases": [], "types": ["T044"], "canonical_name": "peptide modification", "definition": "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide. [GOC:mah]"}
{"concept_id": "C1623087", "aliases": ["extrinsic to cell outer membrane"], "types": ["T026"], "canonical_name": "extrinsic component of cell outer membrane", "definition": "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1623088", "aliases": [], "types": ["T026"], "canonical_name": "external side of outer membrane"}
{"concept_id": "C1623089", "aliases": ["intrinsic to external leaflet of plasma membrane", "intrinsic to external side of plasma membrane"], "types": ["T026"], "canonical_name": "intrinsic component of external side of plasma membrane", "definition": "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. [GOC:dos, GOC:mah]"}
{"concept_id": "C1623090", "aliases": ["anaerobic ribonucleoside-triphosphate reductase complex location"], "types": ["T026"], "canonical_name": "anaerobic ribonucleoside-triphosphate reductase complex", "definition": "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit. [GOC:mlg]"}
{"concept_id": "C1623091", "aliases": ["detection of adenosine 3',5'-cyclophosphate", "detection of cyclic AMP", "cAMP detection", "detection of 3',5'-cAMP", "cAMP sensing", "3',5'-cAMP detection", "cyclic AMP detection", "3',5'-cAMP sensing", "detection of 3',5' cAMP"], "types": ["T043"], "canonical_name": "detection of cAMP", "definition": "The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP. [GOC:pg]"}
{"concept_id": "C1623092", "aliases": ["positive regulation of cellular metabolism", "up regulation of cellular metabolic process", "up-regulation of cellular metabolic process", "upregulation of cellular metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of cellular metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. [GOC:mah]"}
{"concept_id": "C1623096", "aliases": ["negative regulation of pseudopodium formation", "down regulation of pseudopodium formation", "inhibition of pseudopodium formation", "downregulation of pseudopodium formation", "down-regulation of pseudopodium formation"], "types": ["T043"], "canonical_name": "negative regulation of pseudopodium assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia. [GOC:pg]"}
{"concept_id": "C1623100", "aliases": ["DNA replication preinitiation complex location", "pre-IC"], "types": ["T026"], "canonical_name": "DNA replication preinitiation complex", "definition": "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184]"}
{"concept_id": "C1623102", "aliases": ["upregulation of cyclase activity", "up regulation of cyclase activity", "up-regulation of cyclase activity"], "types": ["T044"], "canonical_name": "positive regulation of cyclase activity", "definition": "Any process that activates or increases the activity of a cyclase. [GOC:mah]"}
{"concept_id": "C1623103", "aliases": ["upregulation of stalk cell differentiation", "up regulation of stalk cell differentiation", "up-regulation of stalk cell differentiation", "positive regulation of stalk cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of sorocarp stalk cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum. [GOC:kp, GOC:mtg_sensu, PMID:4338436]"}
{"concept_id": "C1623106", "aliases": ["regulation of stalk cell differentiation"], "types": ["T043"], "canonical_name": "regulation of sorocarp stalk cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum. [GOC:kp, GOC:mtg_sensu, PMID:4338436]"}
{"concept_id": "C1623108", "aliases": ["regulation of cellular breakdown", "regulation of cellular catabolism", "regulation of cellular degradation"], "types": ["T044"], "canonical_name": "regulation of cellular catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. [GOC:mah]"}
{"concept_id": "C1623109", "aliases": ["integral to mitochondrial outer membrane"], "types": ["T026"], "canonical_name": "integral component of mitochondrial outer membrane", "definition": "The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1623111", "aliases": ["positive regulation of cellular degradation", "upregulation of cellular catabolic process", "positive regulation of cellular breakdown", "up-regulation of cellular catabolic process", "up regulation of cellular catabolic process", "positive regulation of cellular catabolism"], "types": ["T044"], "canonical_name": "positive regulation of cellular catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. [GOC:mah]"}
{"concept_id": "C1623115", "aliases": ["extrinsic to organelle membrane"], "types": ["T026"], "canonical_name": "extrinsic component of organelle membrane", "definition": "The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]"}
{"concept_id": "C1623116", "aliases": ["recovery from replication fork stalling", "collapsed replication fork processing", "recovery from replication fork arrest"], "types": ["T045"], "canonical_name": "replication fork processing", "definition": "The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes. [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]"}
{"concept_id": "C1623117", "aliases": ["Tpa", "taurine:pyruvate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde. [EC:2.6.1.77, RHEA:10420]", "canonical_name": "taurine-pyruvate aminotransferase activity"}
{"concept_id": "C1623118", "aliases": ["intrinsic to organelle membrane"], "types": ["T026"], "canonical_name": "intrinsic component of organelle membrane", "definition": "The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1623119", "aliases": ["integral to endosome membrane"], "types": ["T026"], "canonical_name": "integral component of endosome membrane", "definition": "The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1623120", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vesicle fusion", "definition": "Any process that modulates the frequency, rate or extent of vesicle fusion. [GOC:mah]"}
{"concept_id": "C1623121", "aliases": ["intrinsic to mitochondrial outer membrane"], "types": ["T026"], "canonical_name": "intrinsic component of mitochondrial outer membrane", "definition": "The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1623122", "aliases": ["replisome progression complex", "replication fork protection complex location", "replisome progression complex location"], "types": ["T026"], "canonical_name": "replication fork protection complex", "definition": "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. [PMID:15367656]"}
{"concept_id": "C1623123", "aliases": ["regulation of sulfur amino acid metabolism"], "types": ["T044"], "canonical_name": "regulation of sulfur amino acid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. [GOC:mah]"}
{"concept_id": "C1623126", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid modification", "definition": "The alteration of the N-terminal amino acid residue in a protein. [GOC:mah]"}
{"concept_id": "C1623127", "aliases": ["upregulation of vesicle fusion", "up regulation of vesicle fusion", "up-regulation of vesicle fusion"], "types": ["T043"], "canonical_name": "positive regulation of vesicle fusion", "definition": "Any process that activates or increases the frequency, rate or extent of vesicle fusion. [GOC:mah]"}
{"concept_id": "C1623128", "aliases": ["intrinsic to plastid membrane"], "types": ["T026"], "canonical_name": "intrinsic component of plastid membrane", "definition": "The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1623129", "aliases": ["up regulation of defense response", "up-regulation of defense response", "upregulation of defense response"], "types": ["T040"], "canonical_name": "positive regulation of defense response", "definition": "Any process that activates or increases the frequency, rate or extent of a defense response. [GOC:mah]"}
{"concept_id": "C1623130", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mating projection biogenesis"}
{"concept_id": "C1623131", "aliases": ["regulation of prostaglandin formation", "regulation of prostaglandin synthesis", "regulation of prostaglandin anabolism", "regulation of prostaglandin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of prostaglandin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. [GOC:mah]"}
{"concept_id": "C1623132", "aliases": ["MPF complex location"], "types": ["T026"], "canonical_name": "MPF complex", "definition": "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC). [PMID:12045216]"}
{"concept_id": "C1623134", "aliases": ["nuclear RNA-directed RNA polymerase complex location", "RDRC"], "types": ["T026"], "definition": "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain. [GOC:vw, PMID:15607976]", "canonical_name": "nuclear RNA-directed RNA polymerase complex"}
{"concept_id": "C1623136", "aliases": ["bursicon neuropeptide hormone complex location"], "types": ["T026"], "canonical_name": "bursicon neuropeptide hormone complex", "definition": "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits. [GOC:rc]"}
{"concept_id": "C1623138", "aliases": ["chloride binding", "Cl- ion binding"], "types": ["T044"], "canonical_name": "chloride ion binding", "definition": "Binding to a chloride ion (Cl-). [GOC:mah]"}
{"concept_id": "C1623140", "aliases": ["RecQ helicase-Topo III complex", "RecQ family helicase-topoisomerase III complex location", "RecQ helicase-Topo III complex location"], "types": ["T026"], "canonical_name": "RecQ family helicase-topoisomerase III complex", "definition": "A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human. [GOC:bhm, GOC:krc, PMID:15889139]"}
{"concept_id": "C1623141", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA cleavage", "definition": "Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. [GOC:mah]"}
{"concept_id": "C1623142", "aliases": ["Sgs1-Top3 complex location"], "types": ["T026"], "canonical_name": "Sgs1-Top3 complex"}
{"concept_id": "C1623143", "aliases": [], "types": ["T045"], "canonical_name": "chloroplast RNA processing", "definition": "The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules. [GOC:mah]"}
{"concept_id": "C1623145", "aliases": [], "types": ["T040"], "canonical_name": "response to methotrexate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase. [GOC:ef, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1623147", "aliases": ["N-trimethylglycine metabolism", "glycine betaine metabolism", "N-trimethylglycine metabolic process"], "types": ["T044"], "canonical_name": "glycine betaine metabolic process", "definition": "The chemical reactions and pathways involving glycine betaine, N-trimethylglycine. [GOC:mah]"}
{"concept_id": "C1623149", "aliases": [], "types": ["T044"], "canonical_name": "telethonin binding", "definition": "Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. [GOC:mah, PMID:10481174]"}
{"concept_id": "C1623150", "aliases": ["N-trimethylglycine catabolism", "N-trimethylglycine catabolic process", "glycine betaine catabolism", "glycine betaine degradation", "glycine betaine breakdown"], "types": ["T044"], "canonical_name": "glycine betaine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine. [GOC:mah]"}
{"concept_id": "C1623152", "aliases": ["gas vesicle organisation", "gas vesicle biosynthesis", "gas vesicle organization and biogenesis", "gas vesicle formation"], "types": ["T043"], "canonical_name": "gas vesicle organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. [GOC:mah]"}
{"concept_id": "C1623153", "aliases": ["CBC complex location"], "types": ["T026"], "canonical_name": "CBC complex"}
{"concept_id": "C1623154", "aliases": [], "types": ["T044"], "canonical_name": "glycine betaine ABC transporter"}
{"concept_id": "C1623156", "aliases": ["EC2S complex location", "EC2S complex"], "types": ["T026"], "canonical_name": "EC2S complex"}
{"concept_id": "C1623158", "aliases": [], "types": ["T045"], "canonical_name": "chromatin DNA binding", "definition": "Binding to DNA that is assembled into chromatin. [GOC:mah]"}
{"concept_id": "C1623159", "aliases": [], "types": ["T045"], "canonical_name": "nucleosome binding", "definition": "Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:mah]"}
{"concept_id": "C1623160", "aliases": [], "types": ["T026"], "canonical_name": "ethanolamine degradation polyhedral organelle", "definition": "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase. [GOC:js, PMID:11844753]"}
{"concept_id": "C1623161", "aliases": [], "types": ["T045"], "canonical_name": "nucleosomal DNA binding", "definition": "Binding to the DNA portion of a nucleosome. [GOC:mah]"}
{"concept_id": "C1623164", "aliases": [], "types": ["T040"], "canonical_name": "regulation of mating type switching", "definition": "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus. [GOC:mah]"}
{"concept_id": "C1623165", "aliases": ["regulation of brain-derived neurotrophic factor receptor signalling pathway", "regulation of BDNF receptor signaling pathway", "regulation of BDNF receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of brain-derived neurotrophic factor receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C1623166", "aliases": [], "types": ["T026"], "canonical_name": "spitzenkorper", "definition": "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments. [PMID:15701784, PMID:15976451]"}
{"concept_id": "C1623168", "aliases": ["mRNA cap methyltransferase complex location", "mRNA (guanine-N7) methyltransferase complex location", "mRNA (guanine-N7) methyltransferase complex", "mRNA capping enzyme complex location", "mRNA capping enzyme complex"], "types": ["T026"], "canonical_name": "mRNA cap methyltransferase complex", "definition": "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping. [GOC:vw, PMID:10347220]"}
{"concept_id": "C1623169", "aliases": ["regulation of anthocyanin anabolism", "regulation of anthocyanin formation", "regulation of anthocyanin biosynthesis", "regulation of anthocyanin synthesis"], "types": ["T044"], "canonical_name": "regulation of anthocyanin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins. [GOC:mah]"}
{"concept_id": "C1623170", "aliases": ["G-protein signalling, phospholipase D activating pathway", "activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway", "phospholipase D-activating G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "phospholipase D-activating G protein-coupled receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase D (PLD) and a subsequent increase in the intracellular concentration of phosphatidic acid (PA). [GOC:mah, GOC:signaling, PMID:11812783, PMID:15924269]"}
{"concept_id": "C1623171", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of IP3 receptor activity"}
{"concept_id": "C1623172", "aliases": [], "types": ["T044"], "canonical_name": "thyrotropin-releasing hormone receptor ligand"}
{"concept_id": "C1623173", "aliases": [], "types": ["T043"], "canonical_name": "plus-end directed microtubule sliding", "definition": "The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules. [GOC:mah, GOC:vw]"}
{"concept_id": "C1623174", "aliases": ["up regulation of exit from mitosis", "up-regulation of exit from mitosis", "upregulation of exit from mitosis"], "types": ["T043"], "canonical_name": "positive regulation of exit from mitosis", "definition": "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). [GOC:mah]"}
{"concept_id": "C1623175", "aliases": ["up-regulation of brain-derived neurotrophic factor receptor activity", "up regulation of brain-derived neurotrophic factor receptor activity", "upregulation of brain-derived neurotrophic factor receptor activity", "positive regulation of brain-derived neurotrophic factor receptor activity", "positive regulation of BDNF receptor activity"], "types": ["T044"], "canonical_name": "positive regulation of brain-derived neurotrophic factor-activated receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity. [GOC:mah]"}
{"concept_id": "C1623176", "aliases": ["regulation of transcription termination, DNA-dependent", "regulation of termination of DNA-dependent transcription", "regulation of DNA-dependent transcription, termination"], "types": ["T045"], "canonical_name": "regulation of DNA-templated transcription, termination", "definition": "Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. [GOC:mlg, GOC:txnOH]"}
{"concept_id": "C1623178", "aliases": ["membrane raft organisation", "lipid raft organization", "membrane raft organization and biogenesis"], "types": ["T043"], "canonical_name": "membrane raft organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1623179", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional attenuation", "definition": "Regulation of transcription through variation in where transcription termination occurs. [GOC:dh, GOC:mlg, ISBN:0198542682]"}
{"concept_id": "C1623183", "aliases": [], "types": ["T026"], "canonical_name": "mating projection tip polarisome", "definition": "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone. [PMID:14734532]"}
{"concept_id": "C1623186", "aliases": ["Tea1 cell-end complex location"], "types": ["T026"], "canonical_name": "Tea1 cell-end complex", "definition": "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity. [PMID:15936270]"}
{"concept_id": "C1623187", "aliases": ["peptidoglycan-based cell wall organisation", "peptidoglycan-based cell wall organization and biogenesis"], "types": ["T043"], "canonical_name": "peptidoglycan-based cell wall organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall. [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1623188", "aliases": ["telomeric heterochromatin formation"], "types": ["T045"], "canonical_name": "telomeric heterochromatin assembly"}
{"concept_id": "C1623193", "aliases": ["cytosolic proteasome regulatory particle, base subcomplex location"], "types": ["T026"], "canonical_name": "cytosolic proteasome regulatory particle, base subcomplex", "definition": "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1623194", "aliases": ["cytosolic proteasome core complex, beta-subunit complex location"], "types": ["T026"], "canonical_name": "cytosolic proteasome core complex, beta-subunit complex", "definition": "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1623195", "aliases": ["regulation of synaptic vesicle fusion to presynaptic membrane", "regulation of synaptic vesicle fusion to pre-synaptic membrane"], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle fusion to presynaptic active zone membrane", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. [GOC:mah]"}
{"concept_id": "C1623198", "aliases": ["Ndc80-MIND-Spc7 complex location", "KNL-1-Mis12-Ndc80", "NMS complex location", "KMN kinetochore network", "Ndc80-MIND-Spc7 complex"], "types": ["T026"], "canonical_name": "NMS complex", "definition": "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes. [PMID:16079914]"}
{"concept_id": "C1623199", "aliases": [], "types": ["T026"], "canonical_name": "xanthophore", "definition": "A chromatophore containing yellow pigment. [ISBN:0395825172]"}
{"concept_id": "C1623205", "aliases": ["downregulation of neurological process", "down regulation of neurological process", "down-regulation of neurological process", "negative regulation of neurophysiological process", "negative regulation of neurological system process", "negative regulation of neurological process"], "types": ["T040"], "canonical_name": "negative regulation of nervous system process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1623206", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein stability", "definition": "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1623208", "aliases": [], "types": ["T040"], "canonical_name": "regulation of heat generation", "definition": "Any process that modulates the rate or extent of heat generation. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1623210", "aliases": [], "types": ["T040"], "canonical_name": "heat generation", "definition": "Any homeostatic process in which an organism produces heat, thereby raising its internal temperature. [GOC:mah]"}
{"concept_id": "C1623212", "aliases": ["plastid NADH dehydrogenase complex location (plastoquinone)"], "types": ["T026"], "canonical_name": "plastid NADH dehydrogenase complex (plastoquinone)"}
{"concept_id": "C1623213", "aliases": ["up-regulation of heat generation", "upregulation of heat generation", "up regulation of heat generation"], "types": ["T040"], "canonical_name": "positive regulation of heat generation", "definition": "Any process that activates or increases the rate or extent of heat generation. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1623214", "aliases": ["down regulation of heat dissipation", "down-regulation of heat dissipation", "downregulation of heat dissipation"], "types": ["T040"], "canonical_name": "negative regulation of heat dissipation", "definition": "Any process that stops, prevents, or reduces the rate or extent of heat dissipation. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1623215", "aliases": [], "types": ["T044"], "canonical_name": "peptide antigen transporter activity"}
{"concept_id": "C1623218", "aliases": [], "types": ["T044"], "canonical_name": "IL-17"}
{"concept_id": "C1623219", "aliases": [], "types": ["T044"], "canonical_name": "A2A adenosine receptor ligand"}
{"concept_id": "C1623220", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1D adrenergic receptor binding", "definition": "Binding to an alpha-1D adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623221", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to extracellular stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. [GOC:mah]"}
{"concept_id": "C1623222", "aliases": ["negative regulation of lipopolysaccharide-mediated signalling pathway", "down-regulation of lipopolysaccharide-mediated signaling pathway", "negative regulation of LPS-mediated signaling pathway", "downregulation of lipopolysaccharide-mediated signaling pathway", "down regulation of lipopolysaccharide-mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of lipopolysaccharide-mediated signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. [GOC:mah]"}
{"concept_id": "C1623224", "aliases": [], "types": ["T044"], "canonical_name": "alpha-2A adrenergic receptor ligand"}
{"concept_id": "C1623225", "aliases": [], "types": ["T044"], "canonical_name": "adrenergic receptor ligand"}
{"concept_id": "C1623226", "aliases": ["flavin-heme chloroperoxidase activity"], "types": ["T044"], "canonical_name": "flavin-haem chloroperoxidase activity"}
{"concept_id": "C1623228", "aliases": [], "types": ["T043"], "canonical_name": "cell envelope biosynthesis"}
{"concept_id": "C1623229", "aliases": [], "types": ["T043"], "definition": "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances. [GOC:jid]", "canonical_name": "growth pattern"}
{"concept_id": "C1623230", "aliases": [], "types": ["T044"], "canonical_name": "beta-2 adrenergic receptor ligand"}
{"concept_id": "C1623231", "aliases": [], "types": ["T044"], "canonical_name": "monocarboxylate carrier"}
{"concept_id": "C1623232", "aliases": [], "types": ["T044"], "canonical_name": "aromatic hydrocarbon biosynthesis"}
{"concept_id": "C1623233", "aliases": [], "types": ["T044"], "canonical_name": "beta-3 adrenergic receptor ligand"}
{"concept_id": "C1623234", "aliases": [], "types": ["T044"], "canonical_name": "protein-ligand-dependent protein catabolism"}
{"concept_id": "C1623235", "aliases": [], "types": ["T044"], "canonical_name": "apelin receptor ligand"}
{"concept_id": "C1623238", "aliases": [], "types": ["T044"], "canonical_name": "CXCR4 chemokine receptor ligand"}
{"concept_id": "C1623239", "aliases": [], "types": ["T044"], "canonical_name": "hemoglobin beta binding", "definition": "Binding to a hemoglobin beta chain. [GOC:mah]"}
{"concept_id": "C1623240", "aliases": ["macrophage inflammatory protein-1 alpha receptor binding"], "types": ["T044"], "canonical_name": "CCR1 chemokine receptor binding", "definition": "Binding to a CCR1 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623241", "aliases": [], "types": ["T026"], "canonical_name": "prokaryotic large ribosomal subunit"}
{"concept_id": "C1623242", "aliases": [], "types": ["T044"], "canonical_name": "CCR8 chemokine receptor binding", "definition": "Binding to a CCR8 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623243", "aliases": ["LARC receptor binding"], "types": ["T044"], "canonical_name": "CCR6 chemokine receptor binding", "definition": "Binding to a CCR6 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623244", "aliases": [], "types": ["T044"], "canonical_name": "type 1B melatonin receptor ligand"}
{"concept_id": "C1623245", "aliases": [], "types": ["T044"], "canonical_name": "type 1 metabotropic glutamate receptor binding", "definition": "Binding to a type 1 metabotropic glutamate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623246", "aliases": [], "types": ["T044"], "canonical_name": "type 6 serotonin receptor ligand"}
{"concept_id": "C1623247", "aliases": ["5-hydroxytryptamine 7 receptor binding"], "types": ["T044"], "canonical_name": "type 7 serotonin receptor binding", "definition": "Binding to a type 7 serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623248", "aliases": [], "types": ["T044"], "canonical_name": "kappa-type opioid receptor ligand"}
{"concept_id": "C1623249", "aliases": ["prostanoid EP1 receptor binding"], "types": ["T044"], "canonical_name": "EP1 subtype prostaglandin E2 receptor binding", "definition": "Binding to an EP1 subtype prostaglandin E2 receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623250", "aliases": [], "types": ["T044"], "canonical_name": "neurotensin receptor ligand"}
{"concept_id": "C1623251", "aliases": ["5-hydroxytryptamine 5A receptor binding"], "types": ["T044"], "canonical_name": "type 5A serotonin receptor binding", "definition": "Binding to a type 5A serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623253", "aliases": ["transport of peptides or proteins into host"], "types": ["T043"], "canonical_name": "translocation of peptides or proteins into host", "definition": "The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1623254", "aliases": ["wing trichome organization and biogenesis", "wing hair organization and biogenesis", "wing hair organisation", "imaginal disc-derived wing hair organization and biogenesis"], "types": ["T042"], "canonical_name": "imaginal disc-derived wing hair organization", "definition": "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11064425, PMID:12540853]"}
{"concept_id": "C1623255", "aliases": [], "types": ["T044"], "canonical_name": "M5 muscarinic acetylcholine receptor binding"}
{"concept_id": "C1623256", "aliases": ["metabotropic GABA receptor binding", "GABAB receptor binding", "G-protein coupled GABA receptor binding"], "types": ["T044"], "canonical_name": "G protein-coupled GABA receptor binding", "definition": "Binding to a G protein-coupled (metabotropic) GABA receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623257", "aliases": [], "types": ["T044"], "canonical_name": "type 1A melatonin receptor ligand"}
{"concept_id": "C1623259", "aliases": [], "types": ["T044"], "canonical_name": "neuropeptide Y receptor ligand"}
{"concept_id": "C1623260", "aliases": [], "types": ["T044"], "canonical_name": "type 1 neuromedin U receptor ligand"}
{"concept_id": "C1623261", "aliases": ["5-hydroxytryptamine 2B receptor binding"], "types": ["T044"], "canonical_name": "type 2B serotonin receptor binding", "definition": "Binding to a type 2B serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623263", "aliases": [], "types": ["T044"], "canonical_name": "prostaglandin D2 receptor ligand"}
{"concept_id": "C1623264", "aliases": [], "types": ["T044"], "canonical_name": "orexigenic neuropeptide QRFP receptor ligand"}
{"concept_id": "C1623265", "aliases": [], "types": ["T044"], "canonical_name": "M3 muscarinic acetylcholine receptor binding"}
{"concept_id": "C1623266", "aliases": [], "types": ["T042"], "canonical_name": "wing prehair outgrowth"}
{"concept_id": "C1623268", "aliases": [], "types": ["T044"], "canonical_name": "type 1 somatostatin receptor ligand"}
{"concept_id": "C1623269", "aliases": [], "types": ["T044"], "canonical_name": "type 4 proteinase activated receptor binding", "definition": "Binding to a type 4 proteinase activated receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623270", "aliases": [], "types": ["T044"], "canonical_name": "type 5 somatostatin receptor ligand"}
{"concept_id": "C1623273", "aliases": [], "types": ["T044"], "canonical_name": "type B gastrin/cholecystokinin receptor binding", "definition": "Binding to a type B gastrin/cholecystokinin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623274", "aliases": ["prostanoid EP4 receptor binding"], "types": ["T044"], "canonical_name": "EP4 subtype prostaglandin E2 receptor binding", "definition": "Binding to an EP4 subtype prostaglandin E2 receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623275", "aliases": [], "types": ["T044"], "canonical_name": "vasopressin receptor ligand"}
{"concept_id": "C1623276", "aliases": ["VIP receptor binding"], "types": ["T044"], "canonical_name": "vasoactive intestinal polypeptide receptor binding", "definition": "Binding to a vasoactive intestinal polypeptide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623277", "aliases": [], "types": ["T026"], "canonical_name": "late endosome lumen", "definition": "The volume enclosed by the membrane of a late endosome. [GOC:mah]"}
{"concept_id": "C1623278", "aliases": ["thrombin receptor binding"], "types": ["T044"], "canonical_name": "type 1 proteinase activated receptor binding", "definition": "Binding to a type 1 proteinase activated receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623279", "aliases": [], "types": ["T044"], "canonical_name": "Edg-5 sphingosine 1-phosphate receptor binding", "definition": "Binding to an Edg-5 sphingosine 1-phosphate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623280", "aliases": ["mineralocorticoid receptor signalling pathway"], "types": ["T044"], "canonical_name": "mineralocorticoid receptor signaling pathway", "definition": "The series of molecular signals initiated by mineralocorticoid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, PMID:11027914, PMID:12606724]"}
{"concept_id": "C1623281", "aliases": [], "types": ["T026"], "canonical_name": "plastid thylakoid", "definition": "Any thylakoid within a plastid. [GOC:pz]"}
{"concept_id": "C1623283", "aliases": [], "types": ["T043"], "canonical_name": "pyridoxamine transport", "definition": "The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. [GOC:mah]"}
{"concept_id": "C1623286", "aliases": [], "types": ["T044"], "canonical_name": "cholecystokinin receptor ligand"}
{"concept_id": "C1623287", "aliases": ["D1A dopamine receptor binding"], "types": ["T044"], "canonical_name": "D1 dopamine receptor binding", "definition": "Binding to a D1 dopamine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623288", "aliases": [], "types": ["T044"], "canonical_name": "Edg-1 sphingosine 1-phosphate receptor ligand"}
{"concept_id": "C1623289", "aliases": [], "types": ["T044"], "canonical_name": "P2Y1 nucleotide receptor ligand"}
{"concept_id": "C1623291", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast membrane", "definition": "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope. [GOC:mah, GOC:pz]"}
{"concept_id": "C1623293", "aliases": ["up regulation of fatty acid beta-oxidation", "upregulation of fatty acid beta-oxidation", "up-regulation of fatty acid beta-oxidation"], "types": ["T043"], "canonical_name": "positive regulation of fatty acid beta-oxidation", "definition": "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation. [GOC:mah]"}
{"concept_id": "C1623294", "aliases": [], "types": ["T026"], "canonical_name": "microbody lumen", "definition": "The volume enclosed by the membranes of a microbody. [GOC:mah]"}
{"concept_id": "C1623295", "aliases": ["organelle intermembrane space"], "types": ["T026"], "canonical_name": "organelle envelope lumen", "definition": "The region between the inner and outer lipid bilayers of an organelle envelope. [GOC:mah]"}
{"concept_id": "C1623296", "aliases": [], "types": ["T044"], "canonical_name": "cortisol receptor binding"}
{"concept_id": "C1623297", "aliases": ["photon capture"], "types": ["T044"], "canonical_name": "light harvesting activity"}
{"concept_id": "C1623300", "aliases": [], "types": ["T044"], "canonical_name": "D4 dopamine receptor ligand"}
{"concept_id": "C1623303", "aliases": ["IGF-I binding"], "types": ["T044"], "canonical_name": "insulin-like growth factor I binding", "definition": "Binding to insulin-like growth factor I. [GOC:mah]"}
{"concept_id": "C1623304", "aliases": ["down regulation of synaptic metaplasticity", "downregulation of synaptic metaplasticity", "down-regulation of synaptic metaplasticity"], "types": ["T042"], "canonical_name": "negative regulation of synaptic metaplasticity", "definition": "A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. [GOC:mah, PMID:8658594]"}
{"concept_id": "C1623306", "aliases": ["carcinine hydrolase activity"], "types": ["T044"], "canonical_name": "beta-alanyl-histamine hydrolase activity", "definition": "Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine. [GOC:rc, PMID:16299587]"}
{"concept_id": "C1623307", "aliases": [], "types": ["T026"], "canonical_name": "membrane-enclosed lumen", "definition": "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. [GOC:add, GOC:mah]"}
{"concept_id": "C1623308", "aliases": ["suborganelle compartment"], "types": ["T026"], "canonical_name": "organelle subcompartment", "definition": "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. [GOC:mah, GOC:pz]"}
{"concept_id": "C1623309", "aliases": ["thiolesterase binding"], "types": ["T044"], "canonical_name": "thioesterase binding", "definition": "Binding to a thioesterase. [GOC:dl]"}
{"concept_id": "C1623310", "aliases": ["P2Y receptor binding", "G-protein coupled nucleotide receptor binding", "metabotropic nucleotide receptor binding"], "types": ["T044"], "canonical_name": "G protein-coupled nucleotide receptor binding", "definition": "Binding to a G protein-coupled (metabotropic) nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623311", "aliases": [], "types": ["T026"], "canonical_name": "oral apparatus", "definition": "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems. [PMID:10503189]"}
{"concept_id": "C1623312", "aliases": [], "types": ["T026"], "canonical_name": "contractile vacuole pore", "definition": "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium. [PMID:10503189]"}
{"concept_id": "C1623315", "aliases": [], "types": ["T026"], "canonical_name": "organelle envelope", "definition": "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. [GOC:mah, GOC:pz]"}
{"concept_id": "C1623316", "aliases": [], "types": ["T044"], "canonical_name": "growth hormone-releasing hormone receptor binding", "definition": "Binding to a growth hormone-releasing hormone receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623317", "aliases": ["type 1 orexin receptor binding"], "types": ["T044"], "canonical_name": "type 1 hypocretin receptor binding", "definition": "Binding to a type 1 hypocretin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623318", "aliases": [], "types": ["T044"], "canonical_name": "H3 histamine receptor ligand"}
{"concept_id": "C1623319", "aliases": [], "types": ["T044"], "canonical_name": "type 2 melanin-concentrating hormone receptor ligand"}
{"concept_id": "C1623320", "aliases": [], "types": ["T044"], "canonical_name": "type 1 galanin receptor ligand"}
{"concept_id": "C1623321", "aliases": [], "types": ["T044"], "canonical_name": "melanocortin receptor ligand"}
{"concept_id": "C1623322", "aliases": [], "types": ["T044"], "canonical_name": "type 2 galanin receptor ligand"}
{"concept_id": "C1623323", "aliases": [], "types": ["T044"], "canonical_name": "P2Y5 nucleotide receptor ligand"}
{"concept_id": "C1623324", "aliases": [], "types": ["T044"], "canonical_name": "P2Y10 nucleotide receptor ligand"}
{"concept_id": "C1623325", "aliases": ["5-hydroxytryptamine 1F receptor binding"], "types": ["T044"], "canonical_name": "type 1F serotonin receptor binding", "definition": "Binding to a type 1F serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623326", "aliases": ["Ins(1,3,4)P3 5-kinase activity", "inositol 1,3,4-trisphosphate 5-kinase activity", "ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity", "inositol-1,3,4-trisphosphate 5-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). [EC:2.7.1.134]", "canonical_name": "ins(1,3,4)P(3) 5-kinase activity"}
{"concept_id": "C1623327", "aliases": ["ecdysone-mediated induction of autophagic cell death of salivary gland cells", "ecdysone-mediated induction of programmed cell death of salivary gland cells by autophagy", "ecdysone-mediated induction of salivary gland cell programmed cell death by autophagy"], "types": ["T043"], "canonical_name": "ecdysone-mediated induction of salivary gland cell autophagic cell death", "definition": "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis. [GOC:bf]"}
{"concept_id": "C1623328", "aliases": ["larval lymph gland haematopoiesis", "larval lymph gland hematopoiesis", "larval lymph gland haemopoiesis"], "types": ["T040"], "canonical_name": "larval lymph gland hemopoiesis", "definition": "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. [GOC:bf, GOC:mtg_sensu, PMID:12445385]"}
{"concept_id": "C1623329", "aliases": ["5-hydroxytryptamine 1D receptor binding"], "types": ["T044"], "canonical_name": "type 1D serotonin receptor binding", "definition": "Binding to a type 1D serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1623330", "aliases": [], "types": ["T043"], "canonical_name": "wing cell fate specification", "definition": "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment. [PMID:10860999]"}
{"concept_id": "C1623337", "aliases": [], "types": ["T044"], "canonical_name": "major histocompatibility complex class I ligand"}
{"concept_id": "C1623343", "aliases": [], "types": ["T043"], "canonical_name": "neuron maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. [GOC:dph, GOC:jl]"}
{"concept_id": "C1623348", "aliases": [], "types": ["T042"], "canonical_name": "regulation of mesodermal cell fate specification", "definition": "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification. [GOC:go_curators]"}
{"concept_id": "C1623394", "aliases": ["protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway", "protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway", "protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway", "protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway", "protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway", "protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway", "protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway", "protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway", "protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway"], "types": ["T044"], "canonical_name": "protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "definition": "The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. [GOC:jl, PMID:11511343]"}
{"concept_id": "C1623405", "aliases": ["downregulation of natural killer cell degranulation", "down regulation of natural killer cell degranulation", "negative regulation of natural killer cell granule exocytosis", "negative regulation of NK cell degranulation", "down-regulation of natural killer cell degranulation", "negative regulation of NK cell granule exocytosis"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell degranulation", "definition": "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation. [ISBN:0781735149]"}
{"concept_id": "C1623410", "aliases": [], "types": ["T043"], "canonical_name": "dictyosome vesicle bud deformation"}
{"concept_id": "C1623415", "aliases": ["RNA synthesis", "RNA anabolism", "RNA biosynthetic process", "RNA biosynthesis"], "types": ["T045"], "definition": "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. [GOC:mah, GOC:txnOH]", "canonical_name": "RNA formation"}
{"concept_id": "C1623431", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate ABC transporter"}
{"concept_id": "C1623432", "aliases": ["bacteriocin ABC transporter", "ABC-type bacteriocin transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type bacteriocin transporter activity", "definition": "Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. [GOC:mlg, PMID:33040342]"}
{"concept_id": "C1623433", "aliases": ["pre-TCR complex location", "pre-T lymphocyte receptor complex", "pre-TCR complex", "pre-T-lymphocyte receptor complex location", "pre-T-cell receptor complex", "pre-T cell receptor complex location", "pre-T lymphocyte receptor complex location", "pre-T-lymphocyte receptor complex", "pre-T-cell receptor complex location"], "types": ["T026"], "canonical_name": "pre-T cell receptor complex", "definition": "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins. [ISBN:0781735149, PMID:12220932]"}
{"concept_id": "C1623435", "aliases": ["negative T-lymphocyte selection", "negative T lymphocyte selection", "negative T-cell selection"], "types": ["T043"], "canonical_name": "negative T cell selection", "definition": "The process of elimination of immature T cells which react strongly with self-antigens. [ISBN:0781735149, PMID:12414722]"}
{"concept_id": "C1623437", "aliases": ["negative regulation of memory T lymphocyte differentiation", "down regulation of memory T cell differentiation", "down-regulation of memory T cell differentiation", "downregulation of memory T cell differentiation", "negative regulation of memory T-cell differentiation", "negative regulation of memory T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of memory T cell differentiation", "definition": "Any process that stops, prevents, or reduces the rate of memory T cell differentiation. [ISBN:0781735149]"}
{"concept_id": "C1623438", "aliases": ["enucleate red blood cell maturation", "enucleate RBC maturation"], "types": ["T043"], "canonical_name": "enucleate erythrocyte maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus. [GOC:go_curators]"}
{"concept_id": "C1623440", "aliases": [], "types": ["T044"], "canonical_name": "formate-C-acetyltransferase-activating enzyme"}
{"concept_id": "C1623443", "aliases": [], "types": ["T044"], "canonical_name": "glutathione binding", "definition": "Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine. [GOC:bf, ISBN:0198506732]"}
{"concept_id": "C1623444", "aliases": ["positive regulation of CD8-positive T-cell differentiation", "positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation", "up-regulation of CD8-positive, alpha-beta T cell differentiation", "positive regulation of CD8-positive T-lymphocyte differentiation", "positive regulation of CD8-positive, alpha beta T lymphocyte differentiation", "positive regulation of CD8-positive, alpha beta T-cell differentiation", "upregulation of CD8-positive, alpha-beta T cell differentiation", "positive regulation of CD8-positive T lymphocyte differentiation", "up regulation of CD8-positive, alpha-beta T cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of CD8-positive, alpha-beta T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1623445", "aliases": ["regulation of CD4-positive T-lymphocyte differentiation", "regulation of CD4-positive, alpha beta T-lymphocyte differentiation", "regulation of CD4-positive T-cell differentiation", "regulation of CD4-positive, alpha beta T cell differentiation", "regulation of CD4-positive T lymphocyte differentiation", "regulation of CD4-positive, alpha beta T-cell differentiation", "regulation of CD4-positive, alpha beta T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of CD4-positive, alpha-beta T cell differentiation", "definition": "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. [GOC:add, GOC:pr, ISBN:0781735149]"}
{"concept_id": "C1623451", "aliases": ["up regulation of DNA binding", "up-regulation of DNA binding", "upregulation of DNA binding"], "types": ["T044"], "canonical_name": "positive regulation of DNA binding", "definition": "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C1623454", "aliases": ["Regulation of MAPK activity", "regulation of mitogen activated protein kinase activity", "regulation of mitogen-activated protein kinase activity"], "types": ["T043"], "canonical_name": "regulation of MAP kinase activity", "definition": "Any process that modulates the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]"}
{"concept_id": "C1623456", "aliases": ["regulation of K+ conductance", "regulation of potassium conductance"], "types": ["T044"], "canonical_name": "regulation of potassium ion conductance"}
{"concept_id": "C1623460", "aliases": [], "types": ["T026"], "canonical_name": "outer endospore membrane", "definition": "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat. [GOC:mlg]"}
{"concept_id": "C1623464", "aliases": ["NT4 binding"], "types": ["T044"], "canonical_name": "NT-4 binding"}
{"concept_id": "C1623466", "aliases": ["endospore wall", "peptidoglycan-based spore wall"], "types": ["T026"], "canonical_name": "endospore external encapsulating structure", "definition": "The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer. [GOC:go_curators, PMID:15035041]"}
{"concept_id": "C1623471", "aliases": [], "types": ["T043"], "canonical_name": "single-species biofilm formation", "definition": "A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. [GOC:cc, GOC:di, GOC:tb]"}
{"concept_id": "C1623473", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic replication fork", "definition": "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1623474", "aliases": [], "types": ["T026"], "definition": "The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid. [GOC:mlg]", "canonical_name": "exosporium"}
{"concept_id": "C1623476", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA stability", "definition": "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. [GOC:jl]"}
{"concept_id": "C1623478", "aliases": ["regulation of pentose phosphate shunt", "regulation of pentose phosphate pathway", "regulation of pentose-phosphate pathway"], "types": ["T044"], "canonical_name": "regulation of pentose-phosphate shunt", "definition": "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis. [GOC:jl]"}
{"concept_id": "C1623479", "aliases": [], "types": ["T044"], "canonical_name": "IgD binding", "definition": "Binding to an immunoglobulin of a D isotype. [PMID:12886015]"}
{"concept_id": "C1623480", "aliases": ["pigment metabolic process during pigment accumulation"], "types": ["T043"], "canonical_name": "pigment metabolism during pigment accumulation"}
{"concept_id": "C1623481", "aliases": ["phosphatidylinositol-3-phosphate-dependent protein kinase binding"], "types": ["T044"], "canonical_name": "3-phosphoinositide-dependent protein kinase binding", "definition": "Binding to a 3-phosphoinositide-dependent protein kinase. [GOC:jl]"}
{"concept_id": "C1623482", "aliases": ["keto acid metabolism", "oxo acid metabolic process", "oxo acid metabolism", "ketoacid metabolism", "ketoacid metabolic process", "keto acid metabolic process", "oxoacid metabolism"], "types": ["T044"], "canonical_name": "oxoacid metabolic process", "definition": "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). [Wikipedia:Oxyacid]"}
{"concept_id": "C1623483", "aliases": ["alkene anabolism", "alkene biosynthesis", "alkene synthesis", "alkene formation"], "types": ["T043"], "canonical_name": "alkene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n. [GOC:jl, Wikipedia:Alkene]"}
{"concept_id": "C1623484", "aliases": ["AKT signaling cascade", "protein kinase B signalling cascade", "AKT signal transduction", "PKB signal transduction", "AKT signaling", "AKT signalling cascade", "PKB signaling cascade", "protein kinase B signaling cascade", "PKB signalling cascade", "PKB signaling", "protein kinase B signal transduction"], "types": ["T044"], "canonical_name": "protein kinase B signaling", "definition": "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. [GOC:bf, PMID:20517722]"}
{"concept_id": "C1623485", "aliases": ["up-regulation of DNA damage response, signal transduction by p53 class mediator", "upregulation of DNA damage response, signal transduction by p53 class mediator", "positive regulation of p53 induced by DNA damage response", "up regulation of DNA damage response, signal transduction by p53 class mediator"], "types": ["T045"], "canonical_name": "positive regulation of DNA damage response, signal transduction by p53 class mediator", "definition": "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:jl]"}
{"concept_id": "C1623486", "aliases": ["2-aminobenzoate metabolism", "2-aminobenzoate metabolic process", "anthranilate metabolism"], "types": ["T044"], "canonical_name": "anthranilate metabolic process", "definition": "The chemical reactions and pathways involving anthranilate (2-aminobenzoate). [GOC:jl]"}
{"concept_id": "C1623487", "aliases": ["downregulation of MAPK activity", "down-regulation of MAPK activity", "negative regulation of mitogen-activated protein kinase activity", "negative regulation of mitogen activated protein kinase activity", "down regulation of MAPK activity"], "types": ["T043"], "canonical_name": "negative regulation of MAP kinase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]"}
{"concept_id": "C1623490", "aliases": ["leucine zipper binding"], "types": ["T044"], "canonical_name": "leucine zipper domain binding", "definition": "Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. [GOC:jl, InterPro:IPR002158]"}
{"concept_id": "C1623493", "aliases": [], "types": ["T044"], "canonical_name": "HLH domain binding", "definition": "Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. [GOC:go_curators, Prosite:PDOC0038]"}
{"concept_id": "C1623494", "aliases": ["regulation of mitogen activated protein kinase cascade", "regulation of mitogen activated protein kinase kinase kinase cascade", "regulation of mitogen-activated protein kinase kinase kinase cascade", "regulation of MAP kinase kinase kinase cascade", "regulation of MAP kinase cascade", "regulation of MAPKKK cascade", "regulation of mitogen-activated protein kinase cascade"], "types": ["T044"], "canonical_name": "regulation of MAPK cascade", "definition": "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. [GOC:go_curators]"}
{"concept_id": "C1623495", "aliases": ["alkyne metabolism"], "types": ["T043"], "canonical_name": "cellular alkyne metabolic process", "definition": "The chemical reactions and pathways involving an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells. [GOC:jl, GOC:krc, Wikipedia:Alkyne]"}
{"concept_id": "C1623496", "aliases": ["2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity"], "types": ["T044"], "canonical_name": "2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "definition": "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. [GOC:jl, PMID:11583838]"}
{"concept_id": "C1623498", "aliases": ["F-type ATPase complex assembly"], "types": ["T044"], "canonical_name": "proton-transporting ATP synthase complex assembly", "definition": "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/]"}
{"concept_id": "C1623499", "aliases": ["malate fermentation"], "types": ["T044"], "canonical_name": "L-malate fermentation"}
{"concept_id": "C1623500", "aliases": ["inhibin A complex location"], "types": ["T026"], "canonical_name": "inhibin A complex", "definition": "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit. [GOC:jl]"}
{"concept_id": "C1623502", "aliases": ["urea breakdown", "urea decomposition", "urea degradation", "urea catabolism"], "types": ["T044"], "canonical_name": "urea catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. [GOC:jl]"}
{"concept_id": "C1623503", "aliases": [], "types": ["T044"], "canonical_name": "ortho-aminobenzoic acid metabolism"}
{"concept_id": "C1623504", "aliases": ["anthranilate breakdown", "anthranilate catabolism", "2-aminobenzoate degradation", "2-aminobenzoate catabolism", "2-aminobenzoate breakdown", "2-aminobenzoate catabolic process", "anthranilate degradation"], "types": ["T044"], "canonical_name": "anthranilate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate). [GOC:jl]"}
{"concept_id": "C1623505", "aliases": [], "types": ["T045"], "canonical_name": "MRF binding", "definition": "Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. [PMID:10966875]"}
{"concept_id": "C1623506", "aliases": [], "types": ["T043"], "canonical_name": "cellular pigment accumulation", "definition": "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. [GOC:jl]"}
{"concept_id": "C1623507", "aliases": [], "types": ["T045"], "canonical_name": "regulation of RNA splicing", "definition": "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. [GOC:jl]"}
{"concept_id": "C1623508", "aliases": ["regulation of secondary metabolism"], "types": ["T040"], "canonical_name": "regulation of secondary metabolic process", "definition": "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. [GOC:jl]"}
{"concept_id": "C1623509", "aliases": ["positive regulation of IGF receptor signaling pathway", "up regulation of insulin-like growth factor receptor signaling pathway", "upregulation of insulin-like growth factor receptor signaling pathway", "positive regulation of IGF receptor signalling pathway", "up-regulation of insulin-like growth factor receptor signaling pathway", "positive regulation of insulin-like growth factor receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of insulin-like growth factor receptor signaling pathway", "definition": "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]"}
{"concept_id": "C1623513", "aliases": ["translational stress response"], "types": ["T043"], "canonical_name": "regulation of translation in response to stress", "definition": "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:jl]"}
{"concept_id": "C1623514", "aliases": ["up regulation of GTPase activity", "upregulation of GTPase activity", "up-regulation of GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of GTPase activity", "definition": "Any process that activates or increases the activity of a GTPase. [GOC:jl, GOC:mah]"}
{"concept_id": "C1623515", "aliases": ["up-regulation of phosphatidylinositol 3-kinase activity", "positive regulation of phosphoinositide 3-kinase activity", "upregulation of phosphatidylinositol 3-kinase activity", "up regulation of phosphatidylinositol 3-kinase activity"], "types": ["T044"], "canonical_name": "positive regulation of phosphatidylinositol 3-kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity. [GOC:bf]"}
{"concept_id": "C1623516", "aliases": [], "types": ["T043"], "canonical_name": "regulation of translation in response to osmotic stress", "definition": "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:jl]"}
{"concept_id": "C1623517", "aliases": [], "types": ["T044"], "canonical_name": "insulin binding", "definition": "Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [ISBN:0198506732]"}
{"concept_id": "C1623518", "aliases": ["IRS [protein] binding", "insulin receptor substrate [protein] binding", "IRS binding"], "types": ["T044"], "canonical_name": "insulin receptor substrate binding", "definition": "Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. [PMID:12829233]"}
{"concept_id": "C1623519", "aliases": ["structure-specific DNA binding"], "types": ["T045"], "canonical_name": "structure specific DNA binding"}
{"concept_id": "C1623521", "aliases": ["Moco binding"], "types": ["T044"], "canonical_name": "molybdopterin cofactor binding", "definition": "Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. [ISSN:09498257]"}
{"concept_id": "C1623523", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nitrogen levels", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. [GOC:jl]"}
{"concept_id": "C1624013", "aliases": ["regulation of CRH secretion", "regulation of CRF secretion", "regulation of corticotropin-releasing factor secretion"], "types": ["T043"], "canonical_name": "regulation of corticotropin-releasing hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion. [GOC:go_curators, PMID:11027914]"}
{"concept_id": "C1624015", "aliases": [], "types": ["T026"], "canonical_name": "nuclear replisome", "definition": "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1624016", "aliases": [], "types": ["T044"], "canonical_name": "regulation of myosin II filament assembly or disassembly"}
{"concept_id": "C1624017", "aliases": ["acetoacetate metabolic process", "3-oxobutanoic acid metabolism", "3-oxobutanoate metabolic process", "acetoacetic acid metabolism", "diacetic acid metabolic process", "3-oxobutanoate metabolism", "3-oxobutanoic acid metabolic process", "beta-ketobutyric acid metabolic process", "beta ketobutyric acid metabolism", "diacetic acid metabolism", "beta-ketobutyric acid metabolism", "beta ketobutyric acid metabolic process", "acetoacetate metabolism"], "types": ["T044"], "canonical_name": "acetoacetic acid metabolic process", "definition": "The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH. [Wikipedia:Acetoacetic_acid]"}
{"concept_id": "C1624018", "aliases": ["alkene metabolism"], "types": ["T043"], "canonical_name": "cellular alkene metabolic process", "definition": "The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells. [GOC:jl, Wikipedia:Alkene]"}
{"concept_id": "C1624019", "aliases": ["regulation of ATPase activity", "regulation of adenosinetriphosphatase activity"], "types": ["T044"], "canonical_name": "regulation of ATP-dependent activity", "definition": "Any process that modulates the rate of an ATP-dependent activity. [GOC:jl]"}
{"concept_id": "C1624020", "aliases": ["Akt binding", "PKB binding"], "types": ["T044"], "canonical_name": "protein kinase B binding", "definition": "Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. [GOC:jl, http://www.heartandmetabolism.org/]"}
{"concept_id": "C1624022", "aliases": ["histone replacement"], "types": ["T045"], "canonical_name": "histone exchange", "definition": "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. [GOC:jl, PMID:11735001, PMID:15066277]"}
{"concept_id": "C1624023", "aliases": ["histidine kinase binding", "histidine-protein kinase binding", "protein-histidine kinase binding"], "types": ["T044"], "canonical_name": "protein histidine kinase binding", "definition": "Binding to a protein histidine kinase. [GOC:jl]"}
{"concept_id": "C1624024", "aliases": ["initiator tRNA phosphoribosyl-transferase activity"], "types": ["T044"], "canonical_name": "tRNA A64-2'-O-ribosylphosphate transferase activity", "definition": "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA. [GOC:jl, PMID:7954819]"}
{"concept_id": "C1624025", "aliases": ["CRF receptor activity", "CRH receptor activity", "adrenocorticotropin-releasing hormone receptor activity", "corticotropin-releasing factor receptor activity"], "types": ["T044"], "canonical_name": "corticotropin-releasing hormone receptor activity", "definition": "Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity. [GOC:signaling, ISBN:0838577016, PMID:11027914, PMID:15134857]"}
{"concept_id": "C1624026", "aliases": ["regulation of rhamnose catabolism", "regulation of rhamnose degradation", "regulation of rhamnose breakdown"], "types": ["T044"], "canonical_name": "regulation of rhamnose catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. [GOC:jl]"}
{"concept_id": "C1624027", "aliases": [], "types": ["T045"], "definition": "Prevention of degradation of RNA molecules. [GOC:go_curators]", "canonical_name": "RNA stabilization"}
{"concept_id": "C1624028", "aliases": ["homocysteine degradation", "homocysteine catabolism", "homocysteine breakdown"], "types": ["T044"], "canonical_name": "homocysteine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. [GOC:jl]"}
{"concept_id": "C1624030", "aliases": ["alkene breakdown", "alkene catabolism", "alkene degradation"], "types": ["T043"], "canonical_name": "alkene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n. [GOC:jl, Wikipedia:Alkene]"}
{"concept_id": "C1624031", "aliases": ["alkyne breakdown", "alkyne catabolism", "alkyne degradation"], "types": ["T043"], "canonical_name": "alkyne catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2. [GOC:jl, GOC:krc, Wikipedia:Alkyne]"}
{"concept_id": "C1624032", "aliases": ["ethanol synthesis during fermentation", "ethanol formation during fermentation"], "types": ["T040"], "canonical_name": "ethanol anabolism during fermentation"}
{"concept_id": "C1624033", "aliases": ["regulation of programmed cell death, neurons", "regulation of apoptosis of neuronal cells", "regulation of neuron apoptosis", "regulation of apoptosis of neurons", "regulation of neuronal cell programmed cell death", "regulation of neuron programmed cell death", "regulation of programmed cell death of neuronal cells"], "types": ["T043"], "canonical_name": "regulation of neuron apoptotic process", "definition": "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]"}
{"concept_id": "C1624034", "aliases": ["2-octaprenyl-6-hydroxy phenol methylase activity", "3-demethylubiquinone-9 3-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine. [GOC:jl, PMID:11583838, PMID:1479344]", "canonical_name": "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity"}
{"concept_id": "C1624035", "aliases": ["response to CRF stimulus", "response to corticotropin-releasing factor stimulus", "response to corticotropin-releasing hormone stimulus", "response to CRH stimulus", "response to corticoliberin stimulus"], "types": ["T043"], "canonical_name": "response to corticotropin-releasing hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response. [PMID:11027914, PMID:15134857, Wikipedia:Corticotropin-releasing_hormone]"}
{"concept_id": "C1624040", "aliases": [], "types": ["T045"], "canonical_name": "bHLH transcription factor binding", "definition": "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. [PMID:9144210]"}
{"concept_id": "C1624041", "aliases": ["2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity"], "types": ["T044"], "canonical_name": "2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "definition": "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. [GOC:jl, PMID:11583838]"}
{"concept_id": "C1624042", "aliases": ["organismal pigment accumulation"], "types": ["T040"], "canonical_name": "pigment accumulation in tissues", "definition": "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus. [GOC:jl]"}
{"concept_id": "C1624043", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial DNA repair", "definition": "The process of restoring mitochondrial DNA after damage. [PMID:12565799, PMID:15189144, PMID:16050976]"}
{"concept_id": "C1624045", "aliases": ["maintenance of clustered regularly interspaced short palindromic repeat elements"], "types": ["T045"], "canonical_name": "maintenance of CRISPR repeat elements", "definition": "Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences. [PMID:16292354]"}
{"concept_id": "C1624046", "aliases": [], "types": ["T043"], "canonical_name": "leucoplast fission", "definition": "The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes. [GOC:jl]"}
{"concept_id": "C1624047", "aliases": ["adenosine 5' monophosphoramidase activity", "adenosine 5'-monophosphoramidate hydrolase activity"], "types": ["T044"], "canonical_name": "adenosine 5'-monophosphoramidase activity", "definition": "Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester. [PMID:11805111, RHEA:67916]"}
{"concept_id": "C1624048", "aliases": [], "types": ["T043"], "canonical_name": "blood vessel endothelial cell migration", "definition": "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. [PMID:11166264]"}
{"concept_id": "C1624049", "aliases": ["6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex location"], "types": ["T026"], "canonical_name": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex"}
{"concept_id": "C1624050", "aliases": ["GET complex location"], "types": ["T026"], "canonical_name": "GET complex", "definition": "An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins. [GOC:krc, GOC:vw, PMID:16269340, PMID:18724936, PMID:32910895]"}
{"concept_id": "C1624051", "aliases": ["down-regulation of phosphatidylinositol 3-kinase activity", "negative regulation of PI3K activity", "negative regulation of phosphoinositide 3-kinase activity", "down regulation of phosphatidylinositol 3-kinase activity", "downregulation of phosphatidylinositol 3-kinase activity"], "types": ["T044"], "canonical_name": "negative regulation of phosphatidylinositol 3-kinase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity. [GOC:bf]"}
{"concept_id": "C1624052", "aliases": [], "types": ["T043"], "canonical_name": "regulation of translation in response to oxidative stress", "definition": "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl]"}
{"concept_id": "C1624053", "aliases": ["UDP-N-acetylglucosamine transferase complex location"], "types": ["T026"], "canonical_name": "UDP-N-acetylglucosamine transferase complex", "definition": "A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis. [GOC:rn, PMID:19129246]"}
{"concept_id": "C1624054", "aliases": ["tRNA methyltransferase complex location"], "types": ["T026"], "canonical_name": "tRNA methyltransferase complex", "definition": "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA. [GOC:jl, PMID:24904644, PMID:9851972]"}
{"concept_id": "C1624055", "aliases": [], "types": ["T043"], "canonical_name": "regulation of blood vessel endothelial cell migration", "definition": "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]"}
{"concept_id": "C1624565", "aliases": [], "types": ["T044"], "canonical_name": "aflatoxin B1 metabolic process"}
{"concept_id": "C1624566", "aliases": [], "types": ["T026"], "canonical_name": "nuclear replication fork", "definition": "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1624567", "aliases": ["prokaryotic replisome"], "types": ["T026"], "canonical_name": "cytoplasmic replisome", "definition": "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins. [GOC:jl, GOC:mtg_sensu]"}
{"concept_id": "C1624569", "aliases": [], "types": ["T026"], "canonical_name": "endospore coat", "definition": "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination. [GOC:mlg]"}
{"concept_id": "C1624575", "aliases": [], "types": ["T040"], "canonical_name": "acquisition of nutrients from host", "definition": "The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc, GOC:jl]"}
{"concept_id": "C1624576", "aliases": [], "types": ["T042"], "canonical_name": "skin morphogenesis", "definition": "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. [GOC:jl, UBERON:0002097]"}
{"concept_id": "C1624577", "aliases": [], "types": ["T026"], "canonical_name": "bacterial nucleoid", "definition": "The region of a bacterial cell to which the DNA is confined. [GOC:jl]"}
{"concept_id": "C1624578", "aliases": ["nitrate disassimilation", "nitrate dissimilation"], "types": ["T044"], "canonical_name": "nitrate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid. [GOC:jl]"}
{"concept_id": "C1624579", "aliases": ["nuclear DNA replication factor C complex location", "nuclear RFC"], "types": ["T026"], "canonical_name": "nuclear DNA replication factor C complex", "definition": "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species. [GOC:mtg_sensu, PMID:14614842]"}
{"concept_id": "C1624580", "aliases": [], "types": ["T044"], "canonical_name": "regulation of carbon utilization", "definition": "Any process that modulates the frequency, rate, or extent of carbon utilization. [GOC:jl]"}
{"concept_id": "C1624581", "aliases": [], "types": ["T044"], "canonical_name": "anchoring"}
{"concept_id": "C1624582", "aliases": ["alkane synthesis", "alkane biosynthesis", "alkane formation", "alkane anabolism"], "types": ["T043"], "canonical_name": "alkane biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2. [GOC:jl, Wikipedia:Alkane]"}
{"concept_id": "C1624583", "aliases": ["alkyne anabolism", "alkyne synthesis", "alkyne formation", "alkyne biosynthesis"], "types": ["T043"], "canonical_name": "alkyne biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2. [GOC:jl, GOC:krc, Wikipedia:Alkyne]"}
{"concept_id": "C1624584", "aliases": ["pigment accumulation in response to external stimulus"], "types": ["T040"], "canonical_name": "pigment accumulation", "definition": "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. [GOC:jl]"}
{"concept_id": "C1624585", "aliases": ["phage terminase complex location"], "types": ["T026"], "canonical_name": "phage terminase complex"}
{"concept_id": "C1624586", "aliases": [], "types": ["T044"], "canonical_name": "ortho-aminobenzoic acid catabolism"}
{"concept_id": "C1624588", "aliases": ["regulation of p53 induced by DNA damage response"], "types": ["T044"], "canonical_name": "regulation of DNA damage response, signal transduction by p53 class mediator", "definition": "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:jl]"}
{"concept_id": "C1624589", "aliases": ["alkane catabolism", "alkane breakdown", "alkane degradation"], "types": ["T043"], "canonical_name": "alkane catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2. [GOC:jl, Wikipedia:Alkane]"}
{"concept_id": "C1624590", "aliases": [], "types": ["T040"], "canonical_name": "pigment accumulation in tissues in response to UV light", "definition": "The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus. [GOC:jl]"}
{"concept_id": "C1624593", "aliases": ["centromere specific nucleosome", "centromeric nucleosome"], "types": ["T026"], "canonical_name": "centromere-specific nucleosome"}
{"concept_id": "C1624594", "aliases": ["acetoacetic acid catabolism", "acetoacetic acid degradation", "acetoacetic acid breakdown"], "types": ["T044"], "canonical_name": "acetoacetic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH. [GOC:jl]"}
{"concept_id": "C1624595", "aliases": ["dimethyl ketone metabolism", "propan-2-one metabolism", "2-propanone metabolism", "dimethyl ketone metabolic process", "2-propanone metabolic process", "propan-2-one metabolic process", "acetone metabolism"], "types": ["T044"], "canonical_name": "acetone metabolic process", "definition": "The chemical reactions and pathways involving acetone, propan-2-one. [GOC:jl]"}
{"concept_id": "C1624596", "aliases": ["up-regulation of neuron apoptosis", "positive regulation of programmed cell death, neurons", "positive regulation of neuron apoptosis", "up regulation of neuron apoptosis", "upregulation of neuron apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of neuron apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. [GOC:go_curators, GOC:mtg_apoptosis]"}
{"concept_id": "C1624598", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription factor activity"}
{"concept_id": "C1624600", "aliases": [], "types": ["T040"], "canonical_name": "pigment accumulation in response to UV light", "definition": "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus. [GOC:jl]"}
{"concept_id": "C1624603", "aliases": [], "types": ["T044"], "canonical_name": "regulation of fermentation", "definition": "Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP). [GOC:jl]"}
{"concept_id": "C1624604", "aliases": ["regulation of insulin-like growth factor receptor signalling pathway", "regulation of IGF receptor signalling pathway", "regulation of IGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of insulin-like growth factor receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]"}
{"concept_id": "C1624605", "aliases": ["Ku70:Ku80 heterodimer", "Ku70:Ku80 complex location"], "types": ["T026"], "canonical_name": "Ku70:Ku80 complex", "definition": "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK. [PMID:12518983]"}
{"concept_id": "C1624606", "aliases": ["nuclear matrix organisation", "nucleoskeleton organization", "nuclear matrix organization and biogenesis"], "types": ["T043"], "canonical_name": "nuclear matrix organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1624607", "aliases": ["elaioplast organisation", "elaioplast organization and biogenesis"], "types": ["T043"], "canonical_name": "elaioplast organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored. [GOC:jl]"}
{"concept_id": "C1624608", "aliases": ["periplasmic space organisation", "periplasmic space organization and biogenesis"], "types": ["T043"], "canonical_name": "periplasmic space organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1624609", "aliases": ["sequence specific DNA binding"], "types": ["T045"], "canonical_name": "sequence-specific DNA binding", "definition": "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl]"}
{"concept_id": "C1624610", "aliases": ["IP4 binding", "InsP4 binding"], "types": ["T044"], "canonical_name": "inositol 1,3,4,5 tetrakisphosphate binding", "definition": "Binding to inositol 1,3,4,5 tetrakisphosphate. [GOC:go_curators]"}
{"concept_id": "C1624611", "aliases": [], "types": ["T043"], "canonical_name": "peroxisomal transport", "definition": "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. [GOC:jl]"}
{"concept_id": "C1624612", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell migration", "definition": "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:go_curators]"}
{"concept_id": "C1624613", "aliases": [], "types": ["T044"], "canonical_name": "lipoamide binding", "definition": "Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group. [GOC:go_curators]"}
{"concept_id": "C1624614", "aliases": ["tRNA (m2G10) methyltransferase complex location"], "types": ["T026"], "canonical_name": "tRNA (m2G10) methyltransferase complex", "definition": "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p. [PMID:15899842]"}
{"concept_id": "C1625121", "aliases": ["lingua morphogenesis"], "types": ["T042"], "canonical_name": "tongue morphogenesis", "definition": "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. [GOC:jl, UBERON:0001723]"}
{"concept_id": "C1625122", "aliases": ["formamide metabolism"], "types": ["T044"], "canonical_name": "formamide metabolic process", "definition": "The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid. [GOC:jl]"}
{"concept_id": "C1625123", "aliases": [], "types": ["T043"], "canonical_name": "regulation of carbohydrate utilization", "definition": "Any process that modulates the frequency, rate or extent of carbohydrate utilization. [GOC:jl]"}
{"concept_id": "C1625124", "aliases": ["inhibin B complex location"], "types": ["T026"], "canonical_name": "inhibin B complex", "definition": "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit. [GOC:jl]"}
{"concept_id": "C1625125", "aliases": ["down-regulation of DNA damage response, signal transduction by p53 class mediator", "downregulation of DNA damage response, signal transduction by p53 class mediator", "down regulation of DNA damage response, signal transduction by p53 class mediator", "negative regulation of p53 induced by DNA damage response"], "types": ["T044"], "canonical_name": "negative regulation of DNA damage response, signal transduction by p53 class mediator", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:jl]"}
{"concept_id": "C1625126", "aliases": ["response to peptide hormone stimulus", "response to polypeptide hormone stimulus"], "types": ["T043"], "canonical_name": "response to peptide hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]"}
{"concept_id": "C1625127", "aliases": ["2-propanone catabolic process", "2-propanone catabolism", "acetone degradation", "dimethyl ketone catabolic process", "acetone catabolism", "propan-2-one catabolism", "dimethyl ketone catabolism", "acetone breakdown", "propan-2-one catabolic process"], "types": ["T044"], "canonical_name": "acetone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one. [GOC:jl]"}
{"concept_id": "C1625129", "aliases": [], "types": ["T044"], "canonical_name": "regulation of myosin II filament assembly", "definition": "Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules. [GOC:jl]"}
{"concept_id": "C1625130", "aliases": ["acetoacetic acid formation", "acetoacetic acid anabolism", "acetoacetic acid biosynthesis", "acetoacetic acid synthesis"], "types": ["T044"], "canonical_name": "acetoacetic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH. [GOC:jl]"}
{"concept_id": "C1625131", "aliases": ["propan-2-one biosynthetic process", "2-propanone biosynthetic process", "dimethyl ketone biosynthetic process", "acetone anabolism", "dimethyl ketone biosynthesis", "acetone synthesis", "acetone biosynthesis", "propan-2-one biosynthesis", "acetone formation", "2-propanone biosynthesis"], "types": ["T044"], "canonical_name": "acetone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of acetone, propan-2-one. [GOC:jl]"}
{"concept_id": "C1625132", "aliases": [], "types": ["T040"], "canonical_name": "anthocyanin accumulation in tissues in response to UV light", "definition": "The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus. [GOC:jl]"}
{"concept_id": "C1625133", "aliases": ["p40", "p35", "interleukin-12 complex location", "IL-12 complex", "interleukin-12 complex", "IL12B", "IL12A"], "types": ["T026"], "definition": "A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space. [GOC:add, GOC:ebc, GOC:mah, PMID:12948519, PMID:1381512]", "canonical_name": "IL-12 complex location"}
{"concept_id": "C1625134", "aliases": [], "types": ["T044"], "canonical_name": "regulation of myosin II filament disassembly", "definition": "Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules. [GOC:jl]"}
{"concept_id": "C1625135", "aliases": ["3-hydroxypropionate pathway", "hydroxypropionate cycle", "hydroxypropionate pathway", "3-hydroxypropionate cycle"], "types": ["T044"], "canonical_name": "carbon fixation by 3-hydroxypropionate cycle", "definition": "An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product. [GOC:jl, PMID:11418572, PMID:15838028]"}
{"concept_id": "C1625136", "aliases": ["steroid hormone mediated signalling"], "types": ["T044"], "canonical_name": "steroid hormone mediated signaling pathway", "definition": "The series of molecular signals mediated by a steroid hormone binding to a receptor. [PMID:12606724]"}
{"concept_id": "C1625137", "aliases": ["malo-lactate fermentation", "malolactate fermentation"], "types": ["T044"], "canonical_name": "malolactic fermentation", "definition": "The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP. [PMID:10427020, PMID:8808948]"}
{"concept_id": "C1625140", "aliases": [], "types": ["T045"], "canonical_name": "regulation of RNA stability", "definition": "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. [GOC:jl]"}
{"concept_id": "C1625141", "aliases": [], "types": ["T040"], "canonical_name": "skeletal muscle plasticity"}
{"concept_id": "C1625142", "aliases": ["skeletal muscle fiber plasticity", "skeletal myofiber plasticity", "skeletal myofibre plasticity", "skeletal muscle fibre plasticity"], "types": ["T042"], "canonical_name": "skeletal muscle fiber adaptation", "definition": "Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]"}
{"concept_id": "C1625143", "aliases": ["regulation of JUNK activity"], "types": ["T043"], "canonical_name": "regulation of JUN kinase activity", "definition": "Any process that modulates the frequency, rate or extent of JUN kinase activity. [GOC:jl]"}
{"concept_id": "C1625145", "aliases": ["inhibin complex location"], "types": ["T026"], "canonical_name": "inhibin complex", "definition": "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B. [GOC:jl]"}
{"concept_id": "C1625146", "aliases": ["2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity"], "types": ["T044"], "canonical_name": "2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "definition": "Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. [GOC:jl, PMID:11583838]"}
{"concept_id": "C1625147", "aliases": ["down-regulation of neuron apoptosis", "negative regulation of programmed cell death, neurons", "down regulation of neuron apoptosis", "downregulation of neuron apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of neuron apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]"}
{"concept_id": "C1625148", "aliases": ["pigment metabolic process during pigmentation"], "types": ["T043"], "canonical_name": "pigment metabolism during pigmentation"}
{"concept_id": "C1625149", "aliases": [], "types": ["T040"], "canonical_name": "muscle plasticity"}
{"concept_id": "C1625152", "aliases": ["down-regulation of insulin-like growth factor receptor signaling pathway", "down regulation of insulin-like growth factor receptor signaling pathway", "negative regulation of IGF receptor signaling pathway", "negative regulation of IGF receptor signalling pathway", "negative regulation of insulin-like growth factor receptor signalling pathway", "downregulation of insulin-like growth factor receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of insulin-like growth factor receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]"}
{"concept_id": "C1625153", "aliases": [], "types": ["T045"], "canonical_name": "maintenance of DNA repeat elements", "definition": "Any process involved in sustaining the fidelity and copy number of DNA repeat elements. [GOC:jl]"}
{"concept_id": "C1625154", "aliases": ["adenosine 5'-diphosphate binding", "adenosine diphosphate binding"], "types": ["T044"], "canonical_name": "ADP binding", "definition": "Binding to ADP, adenosine 5'-diphosphate. [GOC:jl]"}
{"concept_id": "C1625155", "aliases": [], "types": ["T044"], "canonical_name": "angiostatin binding", "definition": "Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis. [PMID:16043488]"}
{"concept_id": "C1625156", "aliases": ["down regulation of blood vessel endothelial cell migration", "down-regulation of blood vessel endothelial cell migration", "downregulation of blood vessel endothelial cell migration"], "types": ["T043"], "canonical_name": "negative regulation of blood vessel endothelial cell migration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]"}
{"concept_id": "C1625157", "aliases": ["protein ser/thr kinase activator activity"], "types": ["T044"], "canonical_name": "protein serine/threonine kinase activator activity", "definition": "Binds to and increases the activity of a protein serine/threonine kinase. [GOC:go_curators]"}
{"concept_id": "C1625159", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lipid kinase activity", "definition": "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. [GOC:bf]"}
{"concept_id": "C1625160", "aliases": [], "types": ["T043"], "canonical_name": "aerobic respiration, using arsenite as electron donor", "definition": "The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems. [GOC:mlg]"}
{"concept_id": "C1625161", "aliases": ["PI3K binding", "phosphoinositide 3-kinase binding"], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase binding", "definition": "Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. [PMID:10209156, PMID:9255069]"}
{"concept_id": "C1625162", "aliases": [], "types": ["T044"], "canonical_name": "regulation of kinase activity", "definition": "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:bf]"}
{"concept_id": "C1654617", "aliases": [], "types": ["T038"], "canonical_name": "regulation of timing of transition from vegetative to reproductive phase", "definition": "The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs. [GOC:jid, PMID:8974397]"}
{"concept_id": "C1654620", "aliases": ["up regulation of biological process", "upregulation of biological process", "positive regulation of physiological process", "up-regulation of biological process"], "types": ["T039"], "canonical_name": "positive regulation of biological process", "definition": "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:jid]"}
{"concept_id": "C1654621", "aliases": ["wing expansion", "wing inflation"], "types": ["T042"], "canonical_name": "imaginal disc-derived wing expansion", "definition": "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing. [GOC:mtg_sensu, GOC:rc]"}
{"concept_id": "C1654622", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic root development", "definition": "The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure. [GOC:tb]"}
{"concept_id": "C1654624", "aliases": ["reduction of pH in cell", "cell pH reduction", "reduction of cellular pH", "cellular acidification"], "types": ["T043"], "canonical_name": "intracellular pH reduction", "definition": "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion. [GOC:ai]"}
{"concept_id": "C1654625", "aliases": ["protein sequestration in nucleus"], "types": ["T043"], "canonical_name": "sequestration of protein in nucleus"}
{"concept_id": "C1654626", "aliases": ["protein storage in nucleus"], "types": ["T043"], "canonical_name": "storage of protein in nucleus"}
{"concept_id": "C1654627", "aliases": ["delta3,5-delta2,4-dienoyl-CoA isomerase activity", "delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase activity"], "types": ["T044"], "canonical_name": "delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity", "definition": "Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA. [PMID:11278886, PMID:16040662, RHEA:45240]"}
{"concept_id": "C1654628", "aliases": [], "types": ["T043"], "canonical_name": "meiotic sister chromatid arm separation", "definition": "The cell cycle process in which sister chromatid arms are physically detached from each other during meiosis. [GOC:ai]"}
{"concept_id": "C1654629", "aliases": ["meiosis I, homologous chromosome movement towards spindle pole"], "types": ["T043"], "canonical_name": "homologous chromosome movement towards spindle pole in meiosis I anaphase", "definition": "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I anaphase. [GOC:ai]"}
{"concept_id": "C1654630", "aliases": ["meiosis II, sister chromosome movement towards spindle pole"], "types": ["T043"], "canonical_name": "sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation", "definition": "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II. [GOC:ai]"}
{"concept_id": "C1654631", "aliases": ["meiotic sister chromatid cohesion along arms", "sister chromatid cohesion along arms at meiosis I"], "types": ["T043"], "canonical_name": "meiotic sister chromatid cohesion, arms", "definition": "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis. [PMID:14730319, PMID:16325576]"}
{"concept_id": "C1654632", "aliases": ["actin crosslinking", "formation of actin crosslink"], "types": ["T043"], "canonical_name": "actin crosslink formation", "definition": "The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. [GOC:ai]"}
{"concept_id": "C1654755", "aliases": ["mucosal-associated lymphoid tissue development"], "types": ["T042"], "canonical_name": "mucosa-associated lymphoid tissue development", "definition": "The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1654756", "aliases": [], "types": ["T042"], "canonical_name": "Peyer's patch development", "definition": "The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1654757", "aliases": ["phytochrome chromophore anabolism", "phytochrome chromophore formation", "phytochrome chromophore synthesis", "phytochrome chromophore biosynthesis"], "types": ["T044"], "canonical_name": "phytochrome chromophore biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form. [GOC:pj, PMID:2909515]"}
{"concept_id": "C1654758", "aliases": [], "types": ["T043"], "canonical_name": "recognition or rejection of self pollen"}
{"concept_id": "C1654759", "aliases": ["self-incompatibility"], "types": ["T043"], "canonical_name": "self incompatibility"}
{"concept_id": "C1654760", "aliases": ["up regulation of pinocytosis", "upregulation of pinocytosis", "up-regulation of pinocytosis"], "types": ["T043"], "canonical_name": "positive regulation of pinocytosis", "definition": "Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. [GOC:go_curators]"}
{"concept_id": "C1654761", "aliases": ["up regulation of cortisol secretion", "upregulation of cortisol secretion", "up-regulation of cortisol secretion"], "types": ["T043"], "canonical_name": "positive regulation of cortisol secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell. [GOC:ai]"}
{"concept_id": "C1654762", "aliases": ["down regulation of corticotropin-releasing hormone secretion", "down-regulation of corticotropin-releasing hormone secretion", "negative regulation of CRH secretion", "downregulation of corticotropin-releasing hormone secretion", "negative regulation of CRF secretion", "negative regulation of corticotropin-releasing factor secretion"], "types": ["T043"], "canonical_name": "negative regulation of corticotropin-releasing hormone secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell. [GOC:ai]"}
{"concept_id": "C1654763", "aliases": ["upregulation of corticotropin-releasing hormone secretion", "positive regulation of CRH secretion", "positive regulation of corticotropin-releasing factor secretion", "up-regulation of corticotropin-releasing hormone secretion", "up regulation of corticotropin-releasing hormone secretion", "positive regulation of CRF secretion"], "types": ["T043"], "canonical_name": "positive regulation of corticotropin-releasing hormone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell. [GOC:ai]"}
{"concept_id": "C1654764", "aliases": [], "types": ["T043"], "canonical_name": "detection of glucocorticoid hormone stimulus", "definition": "The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:ai]"}
{"concept_id": "C1654765", "aliases": [], "types": ["T043"], "canonical_name": "vesicle fusion with vacuole", "definition": "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. [GOC:ai]"}
{"concept_id": "C1654766", "aliases": [], "types": ["T044"], "canonical_name": "ectoine transmembrane transporter activity"}
{"concept_id": "C1654767", "aliases": [], "types": ["T044"], "canonical_name": "glucosylglycerol transport"}
{"concept_id": "C1654768", "aliases": ["mannosylglycerate formation", "mannosylglycerate anabolism", "mannosylglycerate synthesis", "mannosylglycerate biosynthesis"], "types": ["T044"], "canonical_name": "mannosylglycerate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms. [GOC:ai]"}
{"concept_id": "C1654769", "aliases": ["redox sensing"], "types": ["T043"], "canonical_name": "detection of redox state", "definition": "The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. [GOC:mah, PMID:15131240, PMID:16987039]"}
{"concept_id": "C1654770", "aliases": ["up regulation of nuclear division", "upregulation of nuclear division", "up-regulation of nuclear division"], "types": ["T039"], "canonical_name": "positive regulation of nuclear division", "definition": "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. [GOC:ai]"}
{"concept_id": "C1654771", "aliases": ["medium chain fatty acid biosynthetic process", "medium-chain fatty acid formation", "medium-chain fatty acid synthesis", "medium-chain fatty acid biosynthesis", "medium-chain fatty acid anabolism", "medium chain fatty acid biosynthesis"], "types": ["T044"], "canonical_name": "medium-chain fatty acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any fatty acid with a chain length of between C6 and C12. [Wikipedia:Fatty_acid_metabolism]"}
{"concept_id": "C1654772", "aliases": ["intrinsic to Golgi membrane"], "types": ["T026"], "canonical_name": "intrinsic component of Golgi membrane", "definition": "The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1654773", "aliases": ["integral to thylakoid membrane"], "types": ["T026"], "canonical_name": "integral component of thylakoid membrane", "definition": "The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1654774", "aliases": ["SCF4 complex location"], "types": ["T026"], "canonical_name": "SCF4 complex"}
{"concept_id": "C1654775", "aliases": [], "types": ["T044"], "canonical_name": "regulation of SAPK cascade"}
{"concept_id": "C1654926", "aliases": ["embryonic gut morphogenesis"], "types": ["T042"], "canonical_name": "embryonic digestive tract morphogenesis", "definition": "The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:go_curators]"}
{"concept_id": "C1654927", "aliases": ["response to long-night", "response to short-day", "long-night photoperiodism"], "types": ["T040"], "canonical_name": "short-day photoperiodism", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1654928", "aliases": ["long-day photoperiodic control of flowering", "long-day photoperiodic control of flowering time", "response to short-night, flowering", "response to long-day, flowering", "short-night photoperiodism, flowering", "long-day photoperiodic control of inflorescence development"], "types": ["T040"], "canonical_name": "long-day photoperiodism, flowering", "definition": "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1654929", "aliases": [], "types": ["T044"], "canonical_name": "terpene biosynthesis, mevalonate-dependent"}
{"concept_id": "C1654934", "aliases": ["immune evasion"], "types": ["T040"], "definition": "Methods used by pathogenic organisms to evade a host's immune system.", "canonical_name": "evasion of host immune response"}
{"concept_id": "C1654936", "aliases": [], "types": ["T040"], "canonical_name": "active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction"}
{"concept_id": "C1654937", "aliases": [], "types": ["T043"], "canonical_name": "induction of tumor, nodule, or growth in other organism during symbiotic interaction"}
{"concept_id": "C1654938", "aliases": ["negative regulation of calcium mobilization", "negative regulation of release of sequestered calcium ion (Ca2+)", "negative regulation of calcium ion (Ca2+) mobilization"], "types": ["T043"], "canonical_name": "negative regulation of release of stored calcium ion (Ca2+)"}
{"concept_id": "C1654939", "aliases": ["regulation of calcium ion (Ca2+) storage", "regulation of calcium ion (Ca2+) retention", "regulation of sequestering of calcium ion (Ca2+)", "regulation of sequestration of calcium ion (Ca2+)", "regulation of calcium ion (Ca2+) sequestration", "regulation of retention of calcium ion (Ca2+)", "regulation of storage of calcium ion (Ca2+)", "regulation of calcium ion (Ca2+) sequestering"], "types": ["T043"], "canonical_name": "regulation of sequestering of calcium ion", "definition": "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. [GOC:ai]"}
{"concept_id": "C1654940", "aliases": ["perception of orientation with respect to gravity by visual perception"], "types": ["T040"], "canonical_name": "visual perception involved in equilibrioception", "definition": "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity. [GOC:ai]"}
{"concept_id": "C1654942", "aliases": [], "types": ["T026"], "canonical_name": "SCF complex regulator"}
{"concept_id": "C1654943", "aliases": ["meiotic cell cycle modulation", "meiotic cell cycle regulation", "regulation of progression through meiotic cell cycle", "modulation of meiotic cell cycle progression", "regulation of meiotic cell cycle progression"], "types": ["T044"], "canonical_name": "regulation of meiotic cell cycle", "definition": "Any process that modulates the rate or extent of progression through the meiotic cell cycle. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1655046", "aliases": [], "types": ["T044"], "canonical_name": "luciferase monooxygenase activity"}
{"concept_id": "C1655047", "aliases": ["downregulation of biological process", "down-regulation of biological process", "negative regulation of physiological process", "down regulation of biological process"], "types": ["T039"], "canonical_name": "negative regulation of biological process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:jid]"}
{"concept_id": "C1655048", "aliases": ["positive regulation of viral reproduction", "up regulation of viral life cycle", "upregulation of viral life cycle", "positive regulation of viral life cycle", "up-regulation of viral life cycle"], "types": ["T038"], "canonical_name": "positive regulation of viral process", "definition": "Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. [GOC:bf, GOC:jl]"}
{"concept_id": "C1655049", "aliases": [], "types": ["T040"], "canonical_name": "lateral root development", "definition": "The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper. [GOC:tb]"}
{"concept_id": "C1655050", "aliases": ["Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity", "magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)", "Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity"], "types": ["T044"], "canonical_name": "magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity", "definition": "Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. [EC:1.14.13.81, RHEA:33235]"}
{"concept_id": "C1655051", "aliases": [], "types": ["T043"], "canonical_name": "myoblast migration", "definition": "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ai, GOC:mtg_muscle]"}
{"concept_id": "C1655052", "aliases": ["cellular pH regulation", "regulation of cell pH", "regulation of intracellular pH", "cell pH regulation"], "types": ["T040"], "definition": "Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. [GOC:ai, GOC:dph, GOC:tb]", "canonical_name": "pH regulation in cell"}
{"concept_id": "C1655053", "aliases": ["nuclear protein sequestering"], "types": ["T043"], "canonical_name": "nuclear protein sequestration"}
{"concept_id": "C1655054", "aliases": ["regulation of ACTH secretion", "regulation of adrenocorticotropic hormone secretion", "regulation of adrenotropin hormone secretion", "regulation of adrenocorticotropin secretion", "regulation of adrenotropin secretion", "regulation of corticotropic hormone secretion"], "types": ["T043"], "canonical_name": "regulation of corticotropin secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell. [GOC:ai, GOC:dph]"}
{"concept_id": "C1655055", "aliases": ["IAA carboxyl methyltransferase activity"], "types": ["T044"], "canonical_name": "indole acetic acid carboxyl methyltransferase activity", "definition": "Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine. [PMID:16169896]"}
{"concept_id": "C1655056", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1,4-mannosyltransferase activity", "definition": "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage. [PMID:15772281]"}
{"concept_id": "C1655057", "aliases": ["nitric-oxide synthase (type II) biosynthetic process", "nitric-oxide synthase-2 biosynthetic process", "NOS2 synthase biosynthetic process", "nitric-oxide synthase (type II) biosynthesis", "NOS2 synthase biosynthesis", "nitric-oxide synthase 2 biosynthetic process", "nitric-oxide synthase (type 2) biosynthetic process"], "types": ["T044"], "canonical_name": "nitric-oxide synthase (type 2) biosynthesis"}
{"concept_id": "C1655058", "aliases": ["regulation of NOS biosynthesis", "regulation of NO synthase biosynthesis", "regulation of NOS biosynthetic process", "regulation of NO synthase biosynthetic process"], "types": ["T044"], "canonical_name": "regulation of nitric-oxide synthase biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. [GOC:ai]"}
{"concept_id": "C1655060", "aliases": [], "types": ["T044"], "canonical_name": "regulation of actin phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule. [GOC:go_curators]"}
{"concept_id": "C1655061", "aliases": [], "types": ["T043"], "canonical_name": "detection of osmotic stimulus", "definition": "The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal. [GOC:jl]"}
{"concept_id": "C1655065", "aliases": [], "types": ["T043"], "definition": "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. [GOC:mlg]", "canonical_name": "protein unfolding"}
{"concept_id": "C1655066", "aliases": ["protein amino acid acylation"], "types": ["T044"], "canonical_name": "protein acylation", "definition": "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. [GOC:jl]"}
{"concept_id": "C1655223", "aliases": [], "types": ["T043"], "canonical_name": "regulation of compound eye retinal cell programmed cell death", "definition": "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. [GOC:ai]"}
{"concept_id": "C1655224", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of compound eye retinal cell programmed cell death", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. [GOC:ai]"}
{"concept_id": "C1655225", "aliases": [], "types": ["T044"], "canonical_name": "beta-1,3-galactosyltransferase activity", "definition": "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. [PMID:11551958]"}
{"concept_id": "C1655228", "aliases": ["glucosylglycerol metabolism"], "types": ["T044"], "canonical_name": "glucosylglycerol metabolic process", "definition": "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. [GOC:ai]"}
{"concept_id": "C1655230", "aliases": ["regulation of calcium ion concentration in cytoplasm", "cytoplasmic calcium ion concentration regulation"], "types": ["T043"], "canonical_name": "regulation of cytoplasmic calcium ion concentration"}
{"concept_id": "C1655231", "aliases": ["redox signal response"], "types": ["T043"], "canonical_name": "response to redox state", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. [GOC:mah, PMID:15131240, PMID:16987039]"}
{"concept_id": "C1655232", "aliases": ["up regulation of cell division", "up-regulation of cell division", "upregulation of cell division"], "types": ["T039"], "canonical_name": "positive regulation of cell division", "definition": "Any process that activates or increases the frequency, rate or extent of cell division. [GOC:ai]"}
{"concept_id": "C1655234", "aliases": ["downregulation of nuclear division", "down-regulation of nuclear division", "down regulation of nuclear division"], "types": ["T039"], "canonical_name": "negative regulation of nuclear division", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. [GOC:ai]"}
{"concept_id": "C1655235", "aliases": [], "types": ["T044"], "canonical_name": "misfolded protein binding", "definition": "Binding to a misfolded protein. [GOC:ai]"}
{"concept_id": "C1655236", "aliases": ["medium chain fatty acid metabolism", "medium-chain fatty acid metabolism", "medium chain fatty acid metabolic process"], "types": ["T044"], "canonical_name": "medium-chain fatty acid metabolic process", "definition": "The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain length of between C6 and C12. [Wikipedia:Fatty_acid_metabolisms]"}
{"concept_id": "C1655237", "aliases": ["medium-chain fatty acid breakdown", "medium chain fatty acid catabolism", "medium-chain fatty acid catabolism", "medium chain fatty acid catabolic process", "medium-chain fatty acid degradation"], "types": ["T044"], "canonical_name": "medium-chain fatty acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any fatty acid with a chain length of between C6 and C12. [Wikipedia:Fatty_acid_metabolism]"}
{"concept_id": "C1655238", "aliases": ["down regulation of guanylate cyclase activity", "down-regulation of guanylate cyclase activity", "downregulation of guanylate cyclase activity"], "types": ["T044"], "canonical_name": "negative regulation of guanylate cyclase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity. [GOC:mah]"}
{"concept_id": "C1655239", "aliases": ["intrinsic to contractile vacuolar membrane"], "types": ["T026"], "canonical_name": "intrinsic component of contractile vacuolar membrane", "definition": "The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1655240", "aliases": ["positive regulation of progression through preblastoderm mitotic cell cycle", "upregulation of progression through preblastoderm mitotic cell cycle", "positive regulation of preblastoderm mitotic cell cycle progression", "up-regulation of progression through preblastoderm mitotic cell cycle", "up regulation of progression through preblastoderm mitotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of preblastoderm mitotic cell cycle", "definition": "Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1655249", "aliases": [], "types": ["T038"], "canonical_name": "establishment of floral organ orientation", "definition": "The process that determines the orientation of the floral organs with reference to the central axis of the flower. [GOC:jid]"}
{"concept_id": "C1655250", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic animal organ morphogenesis", "definition": "Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:jid]"}
{"concept_id": "C1655251", "aliases": ["cytosolic calcium ion concentration reduction", "reduction of cytosolic calcium ion concentration", "reduction of calcium ion concentration in cytosol"], "types": ["T043"], "canonical_name": "negative regulation of cytosolic calcium ion concentration", "definition": "Any process that decreases the concentration of calcium ions in the cytosol. [GOC:ai]"}
{"concept_id": "C1655252", "aliases": ["mevalonate-independent terpene biosynthesis"], "types": ["T044"], "canonical_name": "terpene biosynthesis, mevalonate-independent"}
{"concept_id": "C1655253", "aliases": ["isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation", "isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis", "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process", "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis"], "types": ["T044"], "canonical_name": "isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism"}
{"concept_id": "C1655254", "aliases": [], "types": ["T040"], "canonical_name": "regulation of catagen"}
{"concept_id": "C1655256", "aliases": [], "types": ["T044"], "canonical_name": "PTEN activity"}
{"concept_id": "C1655259", "aliases": ["regulation of synaptic structural plasticity"], "types": ["T042"], "canonical_name": "regulation of synapse structural plasticity", "definition": "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane. [PMID:11063967, PMID:14976517, PMID:9884123]"}
{"concept_id": "C1655260", "aliases": ["protein heterotetramer formation", "protein heterotetramer biosynthetic process", "protein heterotetramer assembly", "protein heterotetramer biosynthesis"], "types": ["T044"], "canonical_name": "protein heterotetramerization", "definition": "The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. [GOC:go_curators]"}
{"concept_id": "C1655262", "aliases": [], "types": ["T044"], "canonical_name": "phosphodiesterase activator"}
{"concept_id": "C1655263", "aliases": ["5-hydroxytryptamine binding"], "types": ["T044"], "canonical_name": "serotonin binding", "definition": "Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:ai]"}
{"concept_id": "C1655264", "aliases": ["down-regulation of nerve growth factor receptor activity", "negative regulation of NGF receptor activity", "down regulation of nerve growth factor receptor activity", "downregulation of nerve growth factor receptor activity"], "types": ["T044"], "canonical_name": "negative regulation of nerve growth factor receptor activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor. [GOC:ai]"}
{"concept_id": "C1655265", "aliases": ["stress-activated MAPK signaling pathway", "stress-activated MAPK signalling pathway", "stress-activated MAPKKK cascade", "stress-activated MAPKKK signalling pathway", "stress-activated MAPKKK signaling pathway"], "types": ["T044"], "canonical_name": "stress-activated MAPK cascade", "definition": "The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. [GOC:ai, PMID:15936270]"}
{"concept_id": "C1655267", "aliases": ["reduction of calcium ion concentration in smooth endoplasmic reticulum", "reduction of smooth endoplasmic reticulum calcium ion concentration", "smooth endoplasmic reticulum calcium ion concentration reduction", "reduction of calcium ion concentration in smooth ER", "reduction of smooth ER calcium ion concentration", "smooth ER calcium ion concentration reduction"], "types": ["T043"], "canonical_name": "negative regulation of smooth endoplasmic reticulum calcium ion concentration", "definition": "Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum. [GOC:ai]"}
{"concept_id": "C1655268", "aliases": ["regulation of calcium ion (Ca2+) mobilization", "regulation of release of stored calcium ion (Ca2+) into cytosol", "regulation of cytoplasmic release of stored calcium ion (Ca2+)", "regulation of calcium mobilization", "regulation of release of stored calcium ion (Ca2+) into cytoplasm", "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "regulation of release of sequestered calcium ion into cytosol", "definition": "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai, GOC:tb]"}
{"concept_id": "C1655394", "aliases": ["passive viral induction of innate immune response in host", "passive viral activation of innate immune response in host", "passive induction of host innate immune response by virus"], "types": ["T043"], "canonical_name": "passive induction of innate immune response in host by virus"}
{"concept_id": "C1655395", "aliases": ["down regulation of long-day photoperiodism, flowering", "down-regulation of long-day photoperiodism, flowering", "downregulation of long-day photoperiodism, flowering"], "types": ["T039"], "canonical_name": "negative regulation of long-day photoperiodism, flowering", "definition": "Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1655396", "aliases": ["FGF 6 binding"], "types": ["T044"], "canonical_name": "fibroblast growth factor 6 binding"}
{"concept_id": "C1655397", "aliases": [], "types": ["T042"], "canonical_name": "post-embryonic foregut morphogenesis", "definition": "The process in which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase. [GOC:jid, GOC:rc]"}
{"concept_id": "C1655398", "aliases": ["up regulation of cytoskeleton organization", "positive regulation of cytoskeleton organization and biogenesis", "positive regulation of cytoskeleton organisation", "up-regulation of cytoskeleton organization", "upregulation of cytoskeleton organization", "stimulation of cytoskeleton organization", "activation of cytoskeleton organization"], "types": ["T043"], "canonical_name": "positive regulation of cytoskeleton organization", "definition": "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:ai]"}
{"concept_id": "C1655399", "aliases": ["diterpene phytoalexin anabolism", "diterpene phytoalexin biosynthesis", "diterpene phytoalexin synthesis", "diterpene phytoalexin formation"], "types": ["T044"], "canonical_name": "diterpene phytoalexin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses. [GOC:ai]"}
{"concept_id": "C1655400", "aliases": ["downregulation of synapse structural plasticity", "down regulation of synapse structural plasticity", "down-regulation of synapse structural plasticity"], "types": ["T042"], "canonical_name": "negative regulation of synapse structural plasticity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse structural plasticity. [GOC:ai]"}
{"concept_id": "C1655407", "aliases": ["sensory perception of thermal stimulus"], "types": ["T042"], "canonical_name": "sensory perception of temperature stimulus", "definition": "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]"}
{"concept_id": "C1655408", "aliases": ["sensory transduction of light stimulus", "sensory perception, sensory transduction of light stimulus", "sensory transduction of light stimulus during sensory perception", "sensory perception, sensory detection of light stimulus", "sensory detection of light stimulus", "sensory detection of light stimulus during sensory perception"], "types": ["T043"], "canonical_name": "detection of light stimulus involved in sensory perception", "definition": "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. [GOC:ai, GOC:dos]"}
{"concept_id": "C1655409", "aliases": ["cytosolic release of sequestered calcium ion (Ca2+)", "release of stored calcium ion (Ca2+) into cytosol", "cytosolic release of stored calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "release of sequestered calcium ion into cytosol", "definition": "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]"}
{"concept_id": "C1655411", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein binding", "definition": "Any process that modulates the frequency, rate or extent of protein binding. [GOC:go_curators]"}
{"concept_id": "C1655741", "aliases": ["down regulation of oxidoreductase activity", "oxidoreductase inhibitor", "downregulation of oxidoreductase activity", "down-regulation of oxidoreductase activity"], "types": ["T044"], "definition": "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. [GOC:ai]", "canonical_name": "negative regulation of oxidoreductase activity"}
{"concept_id": "C1655746", "aliases": ["down-regulation of behavior", "down regulation of behavior", "downregulation of behavior"], "types": ["T040"], "canonical_name": "negative regulation of behavior", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. [GOC:jid, GOC:pr]"}
{"concept_id": "C1655747", "aliases": ["negative regulation of cellular physiological process", "down-regulation of cellular process", "down regulation of cellular process", "downregulation of cellular process"], "types": ["T043"], "canonical_name": "negative regulation of cellular process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:jid]"}
{"concept_id": "C1655748", "aliases": ["negative regulation of viral reproduction", "down-regulation of viral life cycle", "negative regulation of viral life cycle", "down regulation of viral life cycle", "downregulation of viral life cycle"], "types": ["T038"], "canonical_name": "negative regulation of viral process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. [GOC:bf, GOC:jl]"}
{"concept_id": "C1655749", "aliases": ["magnetoreception, sensory transduction of light stimulus", "sensory transduction of light stimulus during magnetoreception", "magnetoreception, sensory detection of light stimulus", "magnetoreception, detection of light stimulus", "sensory detection of light stimulus during magnetoreception"], "types": ["T040"], "canonical_name": "detection of light stimulus involved in magnetoreception", "definition": "The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field. [GOC:ai, GOC:dos, PMID:15886990, Wikipedia:Magnetoception]"}
{"concept_id": "C1655751", "aliases": ["intracellular alkalinization", "elevation of cellular pH", "cellular alkalinization", "pH elevation in cell", "cell pH elevation"], "types": ["T043"], "canonical_name": "intracellular pH elevation", "definition": "Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion. [GOC:ai]"}
{"concept_id": "C1655752", "aliases": ["maintenance of nuclear protein localization", "maintenance of protein location in cell nucleus", "maintenance of protein localization in nucleus"], "types": ["T043"], "canonical_name": "maintenance of protein location in nucleus", "definition": "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. [GOC:ai]"}
{"concept_id": "C1655753", "aliases": ["adrenocorticotropic hormone secretion", "adrenotropic hormone secretion", "ACTH secretion", "adrenotropin secretion", "corticotropic hormone secretion"], "types": ["T042"], "canonical_name": "corticotropin secretion", "definition": "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus. [GOC:cjm, PMID:11027914]"}
{"concept_id": "C1655754", "aliases": ["meiotic sister chromatid resolution"], "types": ["T043"], "canonical_name": "meiotic sister chromatid separation", "definition": "The process in which sister chromatids are physically detached from each other during meiosis. [GOC:ai, PMID:14730319, PMID:16325576]"}
{"concept_id": "C1655755", "aliases": [], "types": ["T044"], "canonical_name": "inositol tetrakisphosphate kinase activity", "definition": "Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP. [GOC:ai]"}
{"concept_id": "C1655756", "aliases": [], "types": ["T044"], "canonical_name": "inositol trisphosphate kinase activity", "definition": "Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. [GOC:ai]"}
{"concept_id": "C1655757", "aliases": ["NOS biosynthesis", "NO synthase biosynthetic process", "NO synthase biosynthesis", "NOS biosynthetic process"], "types": ["T044"], "canonical_name": "nitric-oxide synthase biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. [EC:1.14.13.39, GOC:ai]"}
{"concept_id": "C1655758", "aliases": ["upregulation of nitric-oxide synthase biosynthetic process", "positive regulation of NOS biosynthetic process", "positive regulation of NO synthase biosynthesis", "up regulation of nitric-oxide synthase biosynthetic process", "up-regulation of nitric-oxide synthase biosynthetic process", "positive regulation of NOS biosynthesis", "positive regulation of NO synthase biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of nitric-oxide synthase biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. [GOC:ai]"}
{"concept_id": "C1655760", "aliases": ["animal skin development"], "types": ["T042"], "canonical_name": "skin development", "definition": "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. [GOC:jl, UBERON:0002097]"}
{"concept_id": "C1655792", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of compound eye retinal cell programmed cell death", "definition": "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. [GOC:ai]"}
{"concept_id": "C1655793", "aliases": [], "types": ["T043"], "canonical_name": "sporocyte differentiation", "definition": "The process in which a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores. [GOC:tair_curators]"}
{"concept_id": "C1655794", "aliases": ["BALT development"], "types": ["T042"], "canonical_name": "bronchial-associated lymphoid tissue development"}
{"concept_id": "C1655795", "aliases": ["gut-associated lymphoid tissue development", "GALT development"], "types": ["T042"], "canonical_name": "GALT development"}
{"concept_id": "C1655796", "aliases": ["nasopharyngeal-associated lymphoid tissue development"], "types": ["T042"], "canonical_name": "NALT development"}
{"concept_id": "C1655797", "aliases": [], "types": ["T042"], "canonical_name": "thymus development", "definition": "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1655798", "aliases": [], "types": ["T044"], "canonical_name": "regulation of metalloenzyme activity"}
{"concept_id": "C1655799", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of metalloenzyme activity"}
{"concept_id": "C1655801", "aliases": ["positive regulation of adrenotropin secretion", "positive regulation of adrenotropic hormone secretion", "positive regulation of adrenocorticotropic hormone secretion", "positive regulation of corticotropic hormone secretion", "upregulation of adrenocorticotropin secretion", "up-regulation of adrenocorticotropin secretion", "positive regulation of adrenocorticotropin secretion", "positive regulation of ACTH secretion", "up regulation of adrenocorticotropin secretion"], "types": ["T043"], "canonical_name": "positive regulation of corticotropin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell. [GOC:ai]"}
{"concept_id": "C1655802", "aliases": ["regulation of calcium ion concentration in cytosol", "cytosolic calcium ion concentration regulation", "calcium ion homeostasis in cytosol"], "types": ["T043"], "canonical_name": "regulation of cytosolic calcium ion concentration", "definition": "Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. [GOC:ai, GOC:mah, GOC:rph]"}
{"concept_id": "C1655803", "aliases": ["negative regulation of nitric-oxide synthase (type II) biosynthesis", "negative regulation of nitric-oxide synthase (type 2) biosynthetic process", "negative regulation of nitric-oxide synthase (type II) biosynthetic process", "negative regulation of nitric-oxide synthase (type 2) biosynthesis", "negative regulation of nitric-oxide synthase 2 biosynthetic process", "negative regulation of NOS2 synthase biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of NOS2 synthase biosynthesis"}
{"concept_id": "C1655804", "aliases": ["GA12-aldehyde oxidase activity"], "types": ["T044"], "canonical_name": "gibberellin 12-aldehyde oxidase activity", "definition": "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). [EC:1.14.13.79, MetaCyc:RXN1F-161]"}
{"concept_id": "C1655805", "aliases": ["short-chain fatty acid synthesis", "short-chain fatty acid biosynthesis", "short-chain fatty acid formation", "short-chain fatty acid anabolism", "short chain fatty acid biosynthetic process", "short chain fatty acid biosynthesis"], "types": ["T044"], "canonical_name": "short-chain fatty acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than C6. [Wikipedia:Fatty_acid_metabolism]"}
{"concept_id": "C1655806", "aliases": [], "types": ["T026"], "canonical_name": "microvillus membrane", "definition": "The portion of the plasma membrane surrounding a microvillus. [GOC:mah]"}
{"concept_id": "C1655807", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell proliferation", "definition": "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1655808", "aliases": [], "types": ["T040"], "canonical_name": "baroreceptor response to increased systemic arterial blood pressure", "definition": "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels. [GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]"}
{"concept_id": "C1655937", "aliases": [], "types": ["T042"], "canonical_name": "establishment of animal organ orientation", "definition": "The process that determines the orientation of an animal organ or tissue with reference to an axis. [GOC:jid]"}
{"concept_id": "C1655938", "aliases": ["embryonic organogenesis"], "types": ["T042"], "canonical_name": "embryonic organ development", "definition": "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:jid]"}
{"concept_id": "C1655939", "aliases": [], "types": ["T040"], "canonical_name": "notochord morphogenesis", "definition": "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. [GOC:jid]"}
{"concept_id": "C1655940", "aliases": ["response to night length, flowering", "photoperiodic control of flowering time", "response to day length, flowering", "photoperiodic control of inflorescence development", "response to photoperiod, flowering"], "types": ["T040"], "canonical_name": "photoperiodism, flowering", "definition": "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1655941", "aliases": ["short-day photoperiodic control of inflorescence development", "short-day photoperiodic control of flowering", "response to short-day, flowering", "long-night photoperiodism, flowering", "response to long-night, flowering", "short-day photoperiodic control of flowering time"], "types": ["T040"], "canonical_name": "short-day photoperiodism, flowering", "definition": "A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1655942", "aliases": ["reduction of calcium ion concentration in cytoplasm", "cytoplasmic calcium ion concentration reduction"], "types": ["T043"], "canonical_name": "reduction of cytoplasmic calcium ion concentration"}
{"concept_id": "C1655943", "aliases": ["elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)"], "types": ["T044"], "canonical_name": "elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)"}
{"concept_id": "C1655944", "aliases": ["elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)"], "types": ["T043"], "canonical_name": "elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)"}
{"concept_id": "C1655945", "aliases": ["upregulation of catagen", "up-regulation of catagen", "up regulation of catagen"], "types": ["T040"], "canonical_name": "positive regulation of catagen"}
{"concept_id": "C1655946", "aliases": ["downregulation of catagen", "down-regulation of catagen", "down regulation of catagen"], "types": ["T040"], "canonical_name": "negative regulation of catagen"}
{"concept_id": "C1655948", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity", "definition": "Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate. [GOC:bf, PMID:9811831]"}
{"concept_id": "C1655949", "aliases": ["evasion or tolerance of defense response of other organism involved in symbiotic interaction"], "types": ["T040"], "canonical_name": "evasion or tolerance of defense response of other organism during symbiotic interaction"}
{"concept_id": "C1655952", "aliases": ["type 2 corticotropin releasing factor receptor binding", "CRHR2 binding", "type 2 corticotropin-releasing factor receptor binding"], "types": ["T044"], "canonical_name": "corticotropin-releasing hormone receptor 2 binding", "definition": "Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery. [PMID:15134857]"}
{"concept_id": "C1655953", "aliases": ["anaphase promoting complex activator"], "types": ["T026"], "canonical_name": "anaphase-promoting complex activator"}
{"concept_id": "C1655954", "aliases": ["perception of stimulus"], "types": ["T044"], "canonical_name": "stimulus sensing"}
{"concept_id": "C1655955", "aliases": ["establishment of meiotic spindle localisation", "spindle positioning during meiosis", "spindle positioning involved in meiotic cell cycle", "meiotic spindle positioning"], "types": ["T043"], "canonical_name": "establishment of meiotic spindle localization", "definition": "The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs. [GOC:ai]"}
{"concept_id": "C1656263", "aliases": ["anterograde axonal transport of synaptic vesicle"], "types": ["T043"], "canonical_name": "anterograde synaptic vesicle transport", "definition": "The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. [GOC:jid, GOC:lmg]"}
{"concept_id": "C1656265", "aliases": ["magnetoreception, sensory perception of mechanical stimulus", "magnetoreception, using mechanical stimulus", "magnetoreception through mechanical stimulus"], "types": ["T042"], "canonical_name": "magnetoreception by sensory perception of mechanical stimulus", "definition": "The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field. [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]"}
{"concept_id": "C1656266", "aliases": ["attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation", "attachment of spindle microtubules to kinetochore involved in meiosis I", "monopolar attachment", "sister kinetochore mono-orientation"], "types": ["T043"], "canonical_name": "monopolar spindle attachment to meiosis I kinetochore", "definition": "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs. [GOC:ai, GOC:clt, GOC:dph, GOC:tb]"}
{"concept_id": "C1656371", "aliases": ["protein retention in nucleus", "nuclear protein retention"], "types": ["T043"], "canonical_name": "protein-nuclear retention"}
{"concept_id": "C1656372", "aliases": ["negative regulation of ACTH secretion", "negative regulation of adrenocorticotropic hormone secretion", "downregulation of adrenocorticotropin secretion", "negative regulation of adrenocorticotropin secretion", "down regulation of adrenocorticotropin secretion", "negative regulation of corticotropic hormone secretion", "negative regulation of adrenotropin secretion", "down-regulation of adrenocorticotropin secretion", "negative regulation of adrenotropic hormone secretion"], "types": ["T043"], "canonical_name": "negative regulation of corticotropin secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell. [GOC:ai]"}
{"concept_id": "C1656373", "aliases": ["UTP-monosaccharide-1-phosphate uridylyltransferase activity", "UDP-monosaccharide pyrophosphorylase activity", "USP", "UDP-monosaccharide diphosphorylase activity", "UDP-sugar pyrophosphorylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide. [EC:2.7.7.64, PMID:15326166]", "canonical_name": "PsUSP"}
{"concept_id": "C1656374", "aliases": ["phosphoglucan, water dikinase activity", "PWD", "OK1"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate. [EC:2.7.9.5, PMID:15618411]", "canonical_name": "ATP:phospho-alpha-glucan, water phosphotransferase activity"}
{"concept_id": "C1656375", "aliases": ["mannan beta-1,4-mannosyltransferase activity"], "types": ["T044"], "canonical_name": "mannan synthase activity", "definition": "Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan. [PMID:14726589]"}
{"concept_id": "C1656376", "aliases": [], "types": ["T044"], "canonical_name": "galactomannan beta-1,4-mannosyltransferase activity"}
{"concept_id": "C1656377", "aliases": ["centromeric meiotic sister chromatin cohesion", "meiotic sister chromatid cohesion at centromere", "sister chromatid cohesion at centromere at meiosis I"], "types": ["T043"], "canonical_name": "meiotic sister chromatid cohesion, centromeric", "definition": "The cell cycle process in which centromeres of sister chromatids are joined during meiosis. [PMID:14730319, PMID:16325576]"}
{"concept_id": "C1656378", "aliases": [], "types": ["T043"], "canonical_name": "meiotic sister chromatid centromere separation", "definition": "The cell cycle process in which the centromeres of sister chromatids are physically detached from each other during meiosis. [GOC:ai, PMID:14730319, PMID:16325576]"}
{"concept_id": "C1656379", "aliases": [], "types": ["T043"], "canonical_name": "actin bundling"}
{"concept_id": "C1656380", "aliases": ["negative regulation of NO synthase biosynthetic process", "negative regulation of NOS biosynthetic process", "negative regulation of NOS biosynthesis", "downregulation of nitric-oxide synthase biosynthetic process", "down regulation of nitric-oxide synthase biosynthetic process", "down-regulation of nitric-oxide synthase biosynthetic process", "negative regulation of NO synthase biosynthesis"], "types": ["T043"], "canonical_name": "negative regulation of nitric-oxide synthase biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. [GOC:ai]"}
{"concept_id": "C1656381", "aliases": ["regulation of nitric-oxide synthase (type II) biosynthetic process", "regulation of nitric-oxide synthase (type 2) biosynthesis", "regulation of nitric-oxide synthase (type II) biosynthesis", "regulation of NOS2 synthase biosynthetic process", "regulation of nitric-oxide synthase 2 biosynthetic process", "regulation of nitric-oxide synthase (type 2) biosynthetic process"], "types": ["T043"], "canonical_name": "regulation of NOS2 synthase biosynthesis"}
{"concept_id": "C1656382", "aliases": ["upregulation of microtubule polymerization or depolymerization", "up-regulation of microtubule polymerization or depolymerization", "up regulation of microtubule polymerization or depolymerization"], "types": ["T043"], "canonical_name": "positive regulation of microtubule polymerization or depolymerization", "definition": "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. [GOC:mah]"}
{"concept_id": "C1656383", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,4-bisphosphate binding", "definition": "Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. [GOC:bf, GOC:go_curators]"}
{"concept_id": "C1656384", "aliases": ["pyrimidine fermentation", "pyrimidine base fermentation"], "types": ["T044"], "canonical_name": "pyrimidine nucleobase fermentation", "definition": "The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP. [GOC:jl]"}
{"concept_id": "C1656385", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular respiration", "definition": "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. [GOC:jl]"}
{"concept_id": "C1656386", "aliases": [], "types": ["T042"], "canonical_name": "regulation of muscle plasticity"}
{"concept_id": "C1656387", "aliases": ["amide metabolism"], "types": ["T044"], "canonical_name": "cellular amide metabolic process", "definition": "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. [GOC:curators]"}
{"concept_id": "C1656388", "aliases": [], "types": ["T043"], "canonical_name": "single-species biofilm formation on inanimate substrate", "definition": "A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. [GOC:cc]"}
{"concept_id": "C1656399", "aliases": ["anchored to plasma membrane"], "types": ["T026"], "canonical_name": "anchored component of plasma membrane", "definition": "The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos, GOC:mah]"}
{"concept_id": "C1656400", "aliases": [], "types": ["T043"], "canonical_name": "compound eye retinal cell programmed cell death", "definition": "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. [PMID:12006672]"}
{"concept_id": "C1656401", "aliases": [], "types": ["T043"], "canonical_name": "induction of compound eye retinal cell programmed cell death"}
{"concept_id": "C1656403", "aliases": ["response to steroid hormone stimulus"], "types": ["T043"], "canonical_name": "response to steroid hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. [GOC:go_curators]"}
{"concept_id": "C1656404", "aliases": ["gut morphogenesis", "alimentary canal morphogenesis", "gastrointestinal tract morphogenesis", "digestive tube morphogenesis", "intestinal morphogenesis"], "types": ["T042"], "canonical_name": "digestive tract morphogenesis", "definition": "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:dph, GOC:go_curators, PMID:12618131]"}
{"concept_id": "C1656405", "aliases": ["down-regulation of pinocytosis", "down regulation of pinocytosis", "downregulation of pinocytosis"], "types": ["T043"], "canonical_name": "negative regulation of pinocytosis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. [GOC:go_curators]"}
{"concept_id": "C1656406", "aliases": [], "types": ["T044"], "canonical_name": "metalloenzyme inhibitor activity"}
{"concept_id": "C1656407", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cortisol secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell. [GOC:ai]"}
{"concept_id": "C1656408", "aliases": [], "types": ["T043"], "canonical_name": "detection of steroid hormone stimulus", "definition": "The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal. [GOC:ai]"}
{"concept_id": "C1656409", "aliases": [], "types": ["T043"], "canonical_name": "ectoine transport", "definition": "The directed movement of ectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria. [GOC:ai]"}
{"concept_id": "C1656410", "aliases": ["glucosylglycerol anabolism", "glucosylglycerol biosynthesis", "glucosylglycerol formation", "glucosylglycerol synthesis"], "types": ["T044"], "canonical_name": "glucosylglycerol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. [GOC:ai]"}
{"concept_id": "C1656411", "aliases": [], "types": ["T044"], "canonical_name": "mannosylglycerate transport"}
{"concept_id": "C1656413", "aliases": ["mannosylglycerate metabolism"], "types": ["T043"], "canonical_name": "mannosylglycerate metabolic process", "definition": "The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms. [GOC:ai, PMID:11562374]"}
{"concept_id": "C1656414", "aliases": ["cytoplasmic calcium ion homeostasis"], "types": ["T043"], "canonical_name": "calcium ion homeostasis in cytoplasm"}
{"concept_id": "C1656415", "aliases": ["positive regulation of NOS2 synthase biosynthetic process", "stimulation of nitric-oxide synthase 2 biosynthetic process", "positive regulation of nitric-oxide synthase (type 2) biosynthesis", "activation of nitric-oxide synthase 2 biosynthetic process", "positive regulation of nitric-oxide synthase (type 2) biosynthetic process", "positive regulation of nitric-oxide synthase (type II) biosynthetic process", "positive regulation of nitric-oxide synthase 2 biosynthetic process", "positive regulation of nitric-oxide synthase (type II) biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of NOS2 synthase biosynthesis"}
{"concept_id": "C1656416", "aliases": ["ent-kaurenoic acid oxidase activity", "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity"], "types": ["T044"], "canonical_name": "ent-kaurenoate oxidase activity", "definition": "Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). [EC:1.14.13.79, MetaCyc:RXN1F-159]"}
{"concept_id": "C1656417", "aliases": ["behavioural response to nutrient"], "types": ["T040"], "canonical_name": "behavioral response to nutrient", "definition": "Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus. [GOC:ai]"}
{"concept_id": "C1656418", "aliases": ["down regulation of cell division", "downregulation of cell division", "down-regulation of cell division"], "types": ["T039"], "canonical_name": "negative regulation of cell division", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. [GOC:ai]"}
{"concept_id": "C1656419", "aliases": ["all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity", "RetSat activity", "all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity", "(13,14)-all-trans-retinol saturase activity", "retinol saturase activity"], "types": ["T044"], "canonical_name": "all-trans-retinol 13,14-reductase activity", "definition": "Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction. [EC:1.3.99.23, RHEA:19193]"}
{"concept_id": "C1656420", "aliases": [], "types": ["T039"], "canonical_name": "response to misfolded protein", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. [GOC:go_curators]"}
{"concept_id": "C1656421", "aliases": ["hearing organ development"], "types": ["T042"], "canonical_name": "ear development", "definition": "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. [GOC:jl, ISBN:0192801023]"}
{"concept_id": "C1656422", "aliases": [], "types": ["T040"], "canonical_name": "single-species biofilm formation in or on host organism", "definition": "A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1656424", "aliases": ["replication fork blocking at rDNA repeats", "replication fork arrest at ribosomal DNA repeats"], "types": ["T045"], "canonical_name": "replication fork arrest at rDNA repeats", "definition": "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer. [GOC:mah, GOC:vw]"}
{"concept_id": "C1656555", "aliases": ["virus entry into host cell", "virion penetration", "viral penetration", "entry of virus into host cell", "phage translocation", "virion penetration into host cell"], "types": ["T043"], "canonical_name": "viral entry into host cell", "definition": "The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. [GOC:jl]"}
{"concept_id": "C1656556", "aliases": ["activation of host immune response by virus"], "types": ["T043"], "canonical_name": "induction by virus of host immune response", "definition": "The induction by a virus of an immune response in the host organism. [GOC:jl]"}
{"concept_id": "C1656557", "aliases": [], "types": ["T042"], "canonical_name": "embryonic organ morphogenesis", "definition": "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:jid]"}
{"concept_id": "C1656558", "aliases": [], "types": ["T044"], "canonical_name": "photosystem I assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane. [GOC:go_curators]"}
{"concept_id": "C1656559", "aliases": ["gut development", "intestine development", "intestinal development"], "types": ["T042"], "canonical_name": "digestive tract development", "definition": "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:go_curators]"}
{"concept_id": "C1656560", "aliases": ["post-embryonic animal organogenesis"], "types": ["T042"], "canonical_name": "post-embryonic animal organ development", "definition": "Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:jid]"}
{"concept_id": "C1656561", "aliases": ["short-night photoperiodism", "response to long-day", "response to short-night"], "types": ["T040"], "canonical_name": "long-day photoperiodism", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1656562", "aliases": ["upregulation of short-day photoperiodism, flowering", "up-regulation of short-day photoperiodism, flowering", "up regulation of short-day photoperiodism, flowering"], "types": ["T039"], "canonical_name": "positive regulation of short-day photoperiodism, flowering", "definition": "Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1656563", "aliases": ["terpenoid formation, mevalonate-independent", "terpenoid synthesis, mevalonate-independent", "terpenoid anabolism, mevalonate-independent", "mevalonate-independent terpenoid biosynthetic process", "mevalonate-independent terpenoid biosynthesis"], "types": ["T044"], "canonical_name": "terpenoid biosynthetic process, mevalonate-independent", "definition": "The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate. [GOC:ai]"}
{"concept_id": "C1656564", "aliases": ["terpenoid anabolism, mevalonate-dependent", "terpenoid synthesis, mevalonate-dependent", "terpenoid formation, mevalonate-dependent"], "types": ["T044"], "canonical_name": "terpenoid biosynthetic process, mevalonate-dependent", "definition": "The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates. [GOC:ai]"}
{"concept_id": "C1656565", "aliases": ["isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process", "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation", "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis", "isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis"], "types": ["T044"], "canonical_name": "isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism"}
{"concept_id": "C1656571", "aliases": ["MTOC-mediated microtubule nucleation", "microtubule nucleation by microtubule organising centre", "microtubule nucleation by MTOC", "microtubule organizing center-mediated microtubule nucleation"], "types": ["T043"], "canonical_name": "microtubule nucleation by microtubule organizing center", "definition": "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center. [GOC:ai]"}
{"concept_id": "C1656573", "aliases": ["down regulation of cortisol secretion", "down-regulation of cortisol secretion", "downregulation of cortisol secretion"], "types": ["T043"], "canonical_name": "negative regulation of cortisol secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell. [GOC:ai]"}
{"concept_id": "C1656574", "aliases": [], "types": ["T043"], "canonical_name": "adenine nucleotide transport", "definition": "The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1656575", "aliases": ["benzalcoumaran-3-one metabolism", "benzalcoumaran-3-one metabolic process", "aurone metabolism"], "types": ["T044"], "canonical_name": "aurone metabolic process", "definition": "The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides. [PMID:20035037]"}
{"concept_id": "C1656576", "aliases": ["calcium ion homeostasis in smooth ER", "regulation of calcium ion concentration in smooth ER", "calcium ion homeostasis in smooth endoplasmic reticulum", "regulation of calcium ion concentration in smooth endoplasmic reticulum", "smooth endoplasmic reticulum calcium ion concentration regulation", "smooth ER calcium ion concentration regulation", "regulation of smooth ER calcium ion concentration", "regulation of smooth endoplasmic reticulum calcium ion concentration", "smooth ER calcium ion homeostasis"], "types": ["T043"], "canonical_name": "smooth endoplasmic reticulum calcium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings. [GOC:ai, GOC:mah]"}
{"concept_id": "C1656577", "aliases": ["response to pyruvaldehyde"], "types": ["T043"], "canonical_name": "response to methylglyoxal", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal. [GOC:ai]"}
{"concept_id": "C1656578", "aliases": ["thiamin pyrophosphate ABC transporter", "thiamine ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type thiamine transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in). [PMID:12175925, PMID:9535878, RHEA:29811]"}
{"concept_id": "C1656579", "aliases": ["positive regulation of sequestration of calcium ion (Ca2+)", "positive regulation of calcium ion (Ca2+) sequestration", "upregulation of sequestering of calcium ion", "up-regulation of sequestering of calcium ion", "positive regulation of calcium ion (Ca2+) storage", "positive regulation of sequestering of calcium ion (Ca2+)", "positive regulation of storage of calcium ion (Ca2+)", "positive regulation of calcium ion (Ca2+) sequestering", "up regulation of sequestering of calcium ion", "positive regulation of calcium ion (Ca2+) retention", "positive regulation of retention of calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "positive regulation of sequestering of calcium ion", "definition": "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. [GOC:ai]"}
{"concept_id": "C1656580", "aliases": ["meiotic spindle orientation", "establishment of spindle orientation involved in meiotic cell cycle", "orienting of meiotic spindle", "establishment of spindle orientation during meiosis"], "types": ["T043"], "canonical_name": "establishment of meiotic spindle orientation", "definition": "Any process that set the alignment of meiotic spindle relative to other cellular structures. [GOC:ai]"}
{"concept_id": "C1656581", "aliases": ["spindle pole body maturation", "SPB organization", "spindle pole body organization and biogenesis", "SPB maturation", "spindle pole body organisation"], "types": ["T043"], "canonical_name": "spindle pole body organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1656595", "aliases": ["passive viral activation of cell-mediated immune response in host", "passive viral induction of cell-mediated immune response in host", "passive induction of host cell-mediated immune response by virus"], "types": ["T043"], "canonical_name": "passive induction of cell-mediated immune response in host by virus"}
{"concept_id": "C1656596", "aliases": ["down regulation of short-day photoperiodism, flowering", "down-regulation of short-day photoperiodism, flowering", "downregulation of short-day photoperiodism, flowering"], "types": ["T039"], "canonical_name": "negative regulation of short-day photoperiodism, flowering", "definition": "Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1656597", "aliases": ["up-regulation of long-day photoperiodism, flowering", "up regulation of long-day photoperiodism, flowering", "upregulation of long-day photoperiodism, flowering"], "types": ["T039"], "canonical_name": "positive regulation of long-day photoperiodism, flowering", "definition": "Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1656598", "aliases": ["downregulation of post-embryonic development", "down regulation of post-embryonic development", "down-regulation of post-embryonic development"], "types": ["T039"], "canonical_name": "negative regulation of post-embryonic development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. [GOC:jid]"}
{"concept_id": "C1656599", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to stimulus", "definition": "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. [GOC:jid]"}
{"concept_id": "C1656600", "aliases": ["upregulation of response to stimulus", "up regulation of response to stimulus", "up-regulation of response to stimulus"], "types": ["T039"], "canonical_name": "positive regulation of response to stimulus", "definition": "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. [GOC:jid]"}
{"concept_id": "C1656601", "aliases": [], "types": ["T043"], "canonical_name": "oocyte fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte. [GOC:go_curators]"}
{"concept_id": "C1656602", "aliases": ["embryonic ectodermal gut development"], "types": ["T042"], "canonical_name": "embryonic ectodermal digestive tract development", "definition": "The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. [GOC:jid, GOC:rc]"}
{"concept_id": "C1656603", "aliases": [], "types": ["T042"], "canonical_name": "post-embryonic anterior midgut (ectodermal) morphogenesis", "definition": "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase. [GOC:jid, GOC:rc]"}
{"concept_id": "C1656604", "aliases": ["regulation of filopodia formation", "regulation of filopodium formation", "regulation of filopodia biosynthesis"], "types": ["T043"], "canonical_name": "regulation of filopodium assembly", "definition": "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1656606", "aliases": ["regulation of stress fibre formation", "regulation of stress fibre biosynthesis"], "types": ["T043"], "canonical_name": "regulation of stress fiber assembly", "definition": "Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai]"}
{"concept_id": "C1656607", "aliases": ["positive regulation of stress fibre formation"], "types": ["T043"], "canonical_name": "positive regulation of stress fibre biosynthesis"}
{"concept_id": "C1656608", "aliases": [], "types": ["T044"], "canonical_name": "D-aminoacyl-tRNA deacylase activity", "definition": "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA. [PMID:14527667]"}
{"concept_id": "C1656617", "aliases": ["active induction of cell-mediated immune response in host by virus", "active viral induction of cell-mediated immune response in host"], "types": ["T043"], "canonical_name": "induction of cell-mediated immune response in host by virus", "definition": "The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection. [GOC:jl]"}
{"concept_id": "C1656618", "aliases": ["active induction of innate immune response in host by virus", "active viral induction of innate immune response in host"], "types": ["T043"], "canonical_name": "induction of innate immune response in host by virus", "definition": "The intentional, virally-encoded stimulation of an innate host defense response to viral infection. [GOC:jl]"}
{"concept_id": "C1656619", "aliases": ["developmental growth of a unicellular organism"], "types": ["T043"], "canonical_name": "developmental cell growth", "definition": "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. [GOC:go_curators, GOC:isa_complete]"}
{"concept_id": "C1656620", "aliases": [], "types": ["T040"], "canonical_name": "non-developmental growth"}
{"concept_id": "C1656621", "aliases": ["non-developmental cell growth"], "types": ["T043"], "canonical_name": "non-developmental growth of a unicellular organism"}
{"concept_id": "C1656622", "aliases": ["oocyte morphogenesis during differentiation"], "types": ["T043"], "canonical_name": "oocyte morphogenesis", "definition": "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. [GOC:go_curators]"}
{"concept_id": "C1656623", "aliases": ["FGF 1 binding"], "types": ["T044"], "canonical_name": "fibroblast growth factor 1 binding"}
{"concept_id": "C1656624", "aliases": ["FGF 3 binding"], "types": ["T044"], "canonical_name": "fibroblast growth factor 3 binding"}
{"concept_id": "C1656625", "aliases": ["FGF 4 binding"], "types": ["T044"], "canonical_name": "fibroblast growth factor 4 binding"}
{"concept_id": "C1656626", "aliases": ["FGF 5 binding"], "types": ["T044"], "canonical_name": "fibroblast growth factor 5 binding"}
{"concept_id": "C1656627", "aliases": ["post-embryonic ectodermal gut development"], "types": ["T042"], "canonical_name": "post-embryonic ectodermal digestive tract development", "definition": "The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. [GOC:jid, GOC:rc]"}
{"concept_id": "C1656628", "aliases": ["embryonic ectodermal gut morphogenesis"], "types": ["T042"], "canonical_name": "embryonic ectodermal digestive tract morphogenesis", "definition": "The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized. [GOC:jid, GOC:rc]"}
{"concept_id": "C1656629", "aliases": [], "types": ["T042"], "canonical_name": "embryonic anterior midgut (ectodermal) morphogenesis", "definition": "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase. [GOC:jid, GOC:rc]"}
{"concept_id": "C1656630", "aliases": [], "types": ["T042"], "canonical_name": "embryonic foregut morphogenesis", "definition": "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase. [GOC:jid, GOC:rc]"}
{"concept_id": "C1656634", "aliases": ["regulation of cytoskeleton organization and biogenesis", "regulation of cytoskeleton organisation"], "types": ["T043"], "canonical_name": "regulation of cytoskeleton organization", "definition": "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:ai]"}
{"concept_id": "C1656635", "aliases": ["negative regulation of stress fibre formation"], "types": ["T043"], "canonical_name": "negative regulation of stress fibre biosynthesis"}
{"concept_id": "C1656636", "aliases": [], "types": ["T044"], "canonical_name": "syn-copalyl diphosphate synthase activity", "definition": "Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate. [MetaCyc:RXN-8528]"}
{"concept_id": "C1656637", "aliases": ["diterpene phytoalexin metabolism"], "types": ["T044"], "canonical_name": "diterpene phytoalexin metabolic process", "definition": "The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units. [GOC:ai, ISBN:0721662544]"}
{"concept_id": "C1656638", "aliases": [], "types": ["T040"], "canonical_name": "recognition of other organism during symbiotic interaction"}
{"concept_id": "C1656641", "aliases": ["up-regulation of synapse structural plasticity", "up regulation of synapse structural plasticity", "upregulation of synapse structural plasticity"], "types": ["T042"], "canonical_name": "positive regulation of synapse structural plasticity", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity. [GOC:ai]"}
{"concept_id": "C1656643", "aliases": ["transport of peptides or proteins into symbiont"], "types": ["T043"], "canonical_name": "translocation of peptides or proteins into symbiont", "definition": "The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1656644", "aliases": [], "types": ["T043"], "canonical_name": "acquisition of nutrients from symbiont", "definition": "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1656745", "aliases": [], "types": ["T042"], "canonical_name": "post-embryonic hindgut morphogenesis", "definition": "The process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase. [GOC:jid, GOC:rc]"}
{"concept_id": "C1656746", "aliases": ["pre-harvest sprouting", "non-vegetative vivipary"], "types": ["T040"], "canonical_name": "seed germination on parent plant", "definition": "The process in which a seed germinates before being shed from the parent plant. [GOC:go_curators]"}
{"concept_id": "C1656747", "aliases": [], "types": ["T043"], "canonical_name": "myoblast fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:dph, GOC:mtg_muscle]"}
{"concept_id": "C1656751", "aliases": [], "types": ["T067"], "canonical_name": "polyphenic determination, influence by genetic factors", "definition": "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues. [GOC:jid]"}
{"concept_id": "C1656752", "aliases": [], "types": ["T038"], "canonical_name": "anther development", "definition": "The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure. [GOC:jid, GOC:sm]"}
{"concept_id": "C1656753", "aliases": [], "types": ["T038"], "canonical_name": "differentiation of tapetal layer"}
{"concept_id": "C1656754", "aliases": ["NFATc1 binding", "NFATc binding"], "types": ["T045"], "canonical_name": "NFAT2 protein binding"}
{"concept_id": "C1656756", "aliases": [], "types": ["T042"], "canonical_name": "regulation of anagen"}
{"concept_id": "C1656757", "aliases": ["up regulation of exogen", "upregulation of exogen", "up-regulation of exogen"], "types": ["T040"], "canonical_name": "positive regulation of exogen"}
{"concept_id": "C1656759", "aliases": ["negative regulation of adrenaline uptake", "down regulation of epinephrine uptake", "down-regulation of epinephrine uptake", "negative regulation of epinephrine import", "downregulation of epinephrine uptake"], "types": ["T043"], "canonical_name": "negative regulation of epinephrine uptake", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell. [GOC:ai]"}
{"concept_id": "C1656760", "aliases": ["germline initiation of meiotic cell cycle", "germline entry into meiotic cell cycle", "germline conversion to meiotic cell cycle"], "types": ["T043"], "canonical_name": "germline cell cycle switching, mitotic to meiotic cell cycle", "definition": "The process in which a germline cell switches cell cycle mode from mitotic to meiotic division. [GOC:ai]"}
{"concept_id": "C1656761", "aliases": ["GTP-dependent polynucleotide 5'-hydroxyl-kinase activity", "GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity"], "types": ["T044"], "canonical_name": "GTP-dependent polynucleotide kinase activity", "definition": "Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. [GOC:curators]"}
{"concept_id": "C1656763", "aliases": ["apical junction complex assembly"], "types": ["T043"], "canonical_name": "apical junction assembly", "definition": "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]"}
{"concept_id": "C1656764", "aliases": ["up-regulation of nerve growth factor receptor activity", "positive regulation of NGF receptor activity", "up regulation of nerve growth factor receptor activity", "upregulation of nerve growth factor receptor activity"], "types": ["T044"], "canonical_name": "positive regulation of nerve growth factor receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor. [GOC:ai]"}
{"concept_id": "C1656765", "aliases": ["endo-1,4-beta-xylanase inhibitor"], "types": ["T044"], "canonical_name": "xylanase inhibitor"}
{"concept_id": "C1656766", "aliases": ["down regulation of lateral mesodermal cell fate specification", "negative regulation of lateral plate mesodermal cell fate specification", "down-regulation of lateral mesodermal cell fate specification", "downregulation of lateral mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of lateral mesodermal cell fate specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate specification. [GOC:jid]"}
{"concept_id": "C1656767", "aliases": [], "types": ["T043"], "canonical_name": "sporocyte development"}
{"concept_id": "C1656769", "aliases": ["embryonic braincase morphogenesis", "embryonic chondrocranium morphogenesis"], "types": ["T040"], "canonical_name": "embryonic neurocranium morphogenesis", "definition": "The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain. [GOC:dsf, GOC:jid, PMID:16049113]"}
{"concept_id": "C1656770", "aliases": [], "types": ["T042"], "canonical_name": "labrum development", "definition": "The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure. [GOC:rc]"}
{"concept_id": "C1656932", "aliases": ["tapetal layer development", "tapetum development"], "types": ["T039"], "canonical_name": "anther wall tapetum development", "definition": "The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure. [GOC:jid, GOC:sm, GOC:tb]"}
{"concept_id": "C1656933", "aliases": ["regulation of SMC proliferation"], "types": ["T043"], "canonical_name": "regulation of smooth muscle cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]"}
{"concept_id": "C1656934", "aliases": [], "types": ["T043"], "canonical_name": "neuron fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [GOC:dph]"}
{"concept_id": "C1656935", "aliases": ["axon extension involved in development"], "types": ["T042"], "canonical_name": "axon extension", "definition": "Long distance growth of a single axon process involved in cellular development. [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]"}
{"concept_id": "C1656936", "aliases": [], "types": ["T042"], "canonical_name": "regulation of axon regeneration", "definition": "Any process that modulates the frequency, rate or extent of axon regeneration. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1656937", "aliases": ["down regulation of collateral sprouting of intact axon in response to injury", "downregulation of collateral sprouting of intact axon in response to injury", "down-regulation of collateral sprouting of intact axon in response to injury"], "types": ["T043"], "canonical_name": "negative regulation of collateral sprouting of intact axon in response to injury", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1656938", "aliases": [], "types": ["T043"], "canonical_name": "regulation of collateral sprouting in absence of injury", "definition": "Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1656939", "aliases": ["down regulation of collateral sprouting in the absence of injury", "downregulation of collateral sprouting in the absence of injury", "down-regulation of collateral sprouting in the absence of injury"], "types": ["T043"], "canonical_name": "negative regulation of collateral sprouting in absence of injury", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting in the absence of injury. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1656940", "aliases": ["acquisition of desiccation tolerance"], "types": ["T038"], "canonical_name": "acquisition of desiccation tolerance", "definition": "The process in which tolerance to severe drying is acquired, before entering into a dry, either dormant or quiescent state. [GOC:PO_curators]"}
{"concept_id": "C1656941", "aliases": ["negative regulation of release of stored calcium ion (Ca2+) into cytosol", "downregulation of release of sequestered calcium ion into cytosol", "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)", "negative regulation of cytosolic release of stored calcium ion (Ca2+)", "down-regulation of release of sequestered calcium ion into cytosol", "down regulation of release of sequestered calcium ion into cytosol"], "types": ["T043"], "canonical_name": "negative regulation of release of sequestered calcium ion into cytosol", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai]"}
{"concept_id": "C1656942", "aliases": ["iron sulfur cluster binding", "Fe/S binding", "iron sulphur cluster binding", "iron-sulphur cluster binding"], "types": ["T044"], "canonical_name": "iron-sulfur cluster binding", "definition": "Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. [GOC:ai]"}
{"concept_id": "C1656943", "aliases": ["2 Fe 2 S cluster binding", "iron-sulfur cluster 2Fe-2S binding", "diiron disulphide cluster binding", "2Fe-2S cluster binding", "2 iron, 2 sulphur cluster binding", "iron-sulphur cluster 2Fe-2S binding", "diiron disulfide cluster binding"], "types": ["T044"], "canonical_name": "2 iron, 2 sulfur cluster binding", "definition": "Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]"}
{"concept_id": "C1656945", "aliases": [], "types": ["T043"], "canonical_name": "keratinocyte migration", "definition": "The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another. [ISBN:0721662544]"}
{"concept_id": "C1656946", "aliases": ["up-regulation of keratinocyte migration", "upregulation of keratinocyte migration", "up regulation of keratinocyte migration"], "types": ["T043"], "canonical_name": "positive regulation of keratinocyte migration", "definition": "Any process that activates or increases the frequency, rate or extent of keratinocyte migration. [GOC:ai]"}
{"concept_id": "C1656947", "aliases": ["flavone metabolism"], "types": ["T044"], "canonical_name": "flavone metabolic process", "definition": "The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). [PMID:18567791]"}
{"concept_id": "C1656949", "aliases": ["phosphotyrosine-interacting domain binding"], "types": ["T044"], "canonical_name": "PTB domain binding", "definition": "Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain. [Pfam:PF02174.5, PMID:15924411]"}
{"concept_id": "C1656952", "aliases": [], "types": ["T043"], "canonical_name": "attachment of spindle microtubules to kinetochore during meiosis II"}
{"concept_id": "C1656953", "aliases": ["regulation of noradrenaline uptake", "regulation of levarterenol uptake", "regulation of norepinephrine import"], "types": ["T043"], "canonical_name": "regulation of norepinephrine uptake", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. [GOC:ai]"}
{"concept_id": "C1656954", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of centrosome localization"}
{"concept_id": "C1656956", "aliases": ["pigment granule organization and biogenesis", "pigment granule organisation"], "types": ["T043"], "canonical_name": "pigment granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. [GOC:rc]"}
{"concept_id": "C1656970", "aliases": ["penetration into host", "host invasion", "invasion of host", "host penetration", "invasion into host"], "types": ["T038"], "canonical_name": "entry into host", "definition": "Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:vw]"}
{"concept_id": "C1656971", "aliases": ["embryonic pharyngeal skeleton morphogenesis"], "types": ["T040"], "canonical_name": "embryonic viscerocranium morphogenesis", "definition": "The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. [GOC:dsf, GOC:jid, PMID:16049113]"}
{"concept_id": "C1656972", "aliases": [], "types": ["T043"], "canonical_name": "oligodendrocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. [GOC:vp, PMID:15139015]"}
{"concept_id": "C1656973", "aliases": ["downregulation of astrocyte differentiation", "down-regulation of astrocyte differentiation", "down regulation of astrocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of astrocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. [GOC:vp, PMID:15139015]"}
{"concept_id": "C1656974", "aliases": [], "types": ["T042"], "canonical_name": "clypeus morphogenesis", "definition": "The process in which the anatomical structures of the clypeus are generated and organized. [GOC:rc]"}
{"concept_id": "C1656975", "aliases": [], "types": ["T042"], "canonical_name": "gland development", "definition": "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. [GOC:jid]"}
{"concept_id": "C1656976", "aliases": ["heart muscle development"], "types": ["T042"], "canonical_name": "cardiac muscle tissue development", "definition": "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. [GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1656977", "aliases": ["cell cortex of cell end"], "types": ["T026"], "canonical_name": "cell cortex of cell tip", "definition": "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell. [GOC:ai]"}
{"concept_id": "C1656978", "aliases": ["cell end"], "types": ["T026"], "canonical_name": "cell tip", "definition": "The region at the end of the longest axis of a cylindrical or elongated cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C1656979", "aliases": ["leucoanthocyanidin metabolism"], "types": ["T044"], "canonical_name": "leucoanthocyanidin metabolic process", "definition": "The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids. [GOC:ai]"}
{"concept_id": "C1656980", "aliases": ["anthocyanidin 3-glucoside-rhamnosyltransferase activity"], "types": ["T044"], "canonical_name": "anthocyanidin-3-glucoside rhamnosyltransferase activity", "definition": "Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP. [PMID:8130800]"}
{"concept_id": "C1656981", "aliases": ["histone lysine H3 K9 methylation", "histone H3K9me", "histone H3 K9 methylation"], "types": ["T044"], "canonical_name": "histone H3-K9 methylation", "definition": "The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone. [GOC:ai, GOC:pr]"}
{"concept_id": "C1656982", "aliases": [], "types": ["T042"], "canonical_name": "lifelong otolith mineralization", "definition": "The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added. [GOC:dsf, PMID:15581873]"}
{"concept_id": "C1656984", "aliases": ["kinetochore formation", "centromere/kinetochore complex maturation", "centromere and kinetochore complex maturation", "chromosome-kinetochore attachment"], "types": ["T044"], "canonical_name": "kinetochore assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:ai]"}
{"concept_id": "C1657113", "aliases": ["down-regulation by symbiont of host defense response", "negative regulation by organism of defense response of other organism involved in symbiotic interaction", "negative regulation of host defenses", "suppression of host defense response", "downregulation by symbiont of host defense response", "suppression of defense response of other organism", "negative regulation by symbiont of host defense response", "down regulation by symbiont of host defense response"], "types": ["T040"], "canonical_name": "suppression of host defenses by symbiont", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1657114", "aliases": ["establishment and maintenance of chromosome position", "chromosome localisation", "establishment and maintenance of chromosome localization"], "types": ["T038"], "canonical_name": "chromosome localization", "definition": "Any process in which a chromosome is transported to, or maintained in, a specific location. [GOC:ai]"}
{"concept_id": "C1657115", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell division", "definition": "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. [GOC:go_curators]"}
{"concept_id": "C1657116", "aliases": ["meiotic chromosome resolution", "chromosome separation during meiosis"], "types": ["T043"], "canonical_name": "meiotic chromosome separation", "definition": "The process in which chromosomes are physically detached from each other during meiosis. [GOC:ai]"}
{"concept_id": "C1657117", "aliases": ["chromosome separation during male meiosis", "male meiosis chromosome resolution"], "types": ["T043"], "canonical_name": "male meiosis chromosome separation", "definition": "The process in which paired chromosomes are physically detached from each other during male meiosis. [GOC:ai]"}
{"concept_id": "C1657118", "aliases": ["female meiosis chromosome resolution", "chromosome separation during female meiosis"], "types": ["T043"], "canonical_name": "female meiosis chromosome separation", "definition": "The process in which paired chromosomes are physically detached from each other during female meiosis. [GOC:ai]"}
{"concept_id": "C1657119", "aliases": ["metaphase plate congression during meiosis"], "types": ["T043"], "canonical_name": "meiotic metaphase plate congression", "definition": "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis. [GOC:ai]"}
{"concept_id": "C1657121", "aliases": [], "types": ["T045"], "canonical_name": "spindle-chromosome interaction"}
{"concept_id": "C1657122", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H3-K9 methylation", "definition": "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. [GOC:ai]"}
{"concept_id": "C1657123", "aliases": ["down-regulation of histone H3-K4 methylation", "down regulation of histone H3-K4 methylation", "downregulation of histone H3-K4 methylation"], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K4 methylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. [GOC:mah]"}
{"concept_id": "C1657124", "aliases": [], "types": ["T045"], "canonical_name": "Mrf4 binding"}
{"concept_id": "C1657127", "aliases": ["upregulation of neurotransmitter transport", "up regulation of neurotransmitter transport", "up-regulation of neurotransmitter transport"], "types": ["T043"], "canonical_name": "positive regulation of neurotransmitter transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1657128", "aliases": ["response to Ca2+ ion"], "types": ["T043"], "canonical_name": "response to calcium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:ai]"}
{"concept_id": "C1657129", "aliases": ["cellular response to folate", "cellular response to vitamin B9"], "types": ["T040"], "canonical_name": "response to folic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. [GOC:ai]"}
{"concept_id": "C1657130", "aliases": ["response to MeHg+", "response to CH3-Hg+"], "types": ["T043"], "canonical_name": "response to methylmercury", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. [GOC:ai]"}
{"concept_id": "C1657131", "aliases": ["up regulation of epinephrine uptake", "positive regulation of adrenaline uptake", "positive regulation of epinephrine import", "up-regulation of epinephrine uptake", "upregulation of epinephrine uptake"], "types": ["T043"], "canonical_name": "positive regulation of epinephrine uptake", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell. [GOC:ai]"}
{"concept_id": "C1657132", "aliases": ["regulation of killing of cells of other organism"], "types": ["T043"], "canonical_name": "regulation of killing of cells of another organism", "definition": "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism. [GOC:ai]"}
{"concept_id": "C1657133", "aliases": ["interphase microtubule nucleation by interphase microtubule organizing center", "microtubule nucleation during interphase by interphase microtubule organizing center", "interphase microtubule organizing center-mediated microtubule nucleation during interphase", "IMTOC-mediated microtubule nucleation during interphase", "interphase microtubule nucleation by interphase microtubule organising centre", "microtubule nucleation during interphase by IMTOC"], "types": ["T079"], "canonical_name": "microtubule nucleation by interphase microtubule organizing center", "definition": "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation. [GOC:ai]"}
{"concept_id": "C1657143", "aliases": [], "types": ["T043"], "canonical_name": "attachment of spindle microtubules to kinetochore during mitosis"}
{"concept_id": "C1657144", "aliases": ["premeiotic S-phase", "S-phase of meiotic cell cycle", "S phase of meiotic cell cycle"], "types": ["T045"], "canonical_name": "meiotic S phase", "definition": "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1657145", "aliases": ["ligase regulator"], "types": ["T044"], "canonical_name": "regulation of ligase activity", "definition": "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. [GOC:ai]"}
{"concept_id": "C1657146", "aliases": ["3',5'-cyclic-AMP phosphodiesterase activator"], "types": ["T044"], "canonical_name": "cAMP phosphodiesterase activator"}
{"concept_id": "C1657226", "aliases": ["post-embryonic gut morphogenesis"], "types": ["T040"], "canonical_name": "post-embryonic digestive tract morphogenesis", "definition": "The process, occurring during the post-embryonic phase, by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:jid, GOC:rc]"}
{"concept_id": "C1657227", "aliases": [], "types": ["T043"], "canonical_name": "myoblast development", "definition": "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:dph, GOC:mtg_muscle]"}
{"concept_id": "C1657228", "aliases": ["trichome distribution", "trichome pattern specification", "trichome spacing", "trichome pattern formation", "trichome pattern biosynthesis"], "types": ["T040"], "canonical_name": "trichome patterning", "definition": "The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes. [GOC:jid, GOC:mtg_sensu, GOC:sm, GOC:tb, ISBN:0865427429, PMID:10368181]"}
{"concept_id": "C1657229", "aliases": [], "types": ["T040"], "canonical_name": "regulation of developmental growth", "definition": "Any process that modulates the frequency, rate or extent of developmental growth. [GOC:go_curators]"}
{"concept_id": "C1657230", "aliases": [], "types": ["T044"], "canonical_name": "stigmasterol UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol. [GOC:ai, RHEA:61828]"}
{"concept_id": "C1657231", "aliases": ["upregulation of unidimensional cell growth", "up-regulation of unidimensional cell growth", "up regulation of unidimensional cell growth"], "types": ["T043"], "canonical_name": "positive regulation of unidimensional cell growth", "definition": "Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis. [GOC:ai]"}
{"concept_id": "C1657232", "aliases": [], "types": ["T043"], "canonical_name": "regulation of bipolar cell growth", "definition": "Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. [GOC:ai]"}
{"concept_id": "C1657233", "aliases": [], "types": ["T043"], "canonical_name": "activation of bipolar cell growth", "definition": "Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell. [GOC:ai]"}
{"concept_id": "C1657234", "aliases": [], "types": ["T043"], "canonical_name": "termination of bipolar cell growth", "definition": "Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell. [GOC:ai]"}
{"concept_id": "C1657235", "aliases": ["NFAT binding", "nuclear factor of activated T cell protein binding"], "types": ["T045"], "canonical_name": "NFAT protein binding", "definition": "Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. [PMID:15928679]"}
{"concept_id": "C1657236", "aliases": ["NFATx binding"], "types": ["T045"], "canonical_name": "NFAT4 protein binding"}
{"concept_id": "C1657240", "aliases": [], "types": ["T044"], "canonical_name": "glycolipid binding", "definition": "Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. [PMID:19635802]"}
{"concept_id": "C1657241", "aliases": ["up-regulation of anagen", "up regulation of anagen", "upregulation of anagen"], "types": ["T040"], "canonical_name": "positive regulation of anagen"}
{"concept_id": "C1657243", "aliases": ["down regulation of protein kinase B signaling cascade", "down-regulation of protein kinase B signaling cascade", "negative regulation of protein kinase B signalling cascade", "downregulation of protein kinase B signaling cascade", "negative regulation of AKT signaling cascade", "negative regulation of PKB signaling cascade", "negative regulation of protein kinase B signaling cascade", "negative regulation of PKB signalling cascade", "negative regulation of AKT signalling cascade"], "types": ["T044"], "canonical_name": "negative regulation of protein kinase B signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. [GOC:ai]"}
{"concept_id": "C1657244", "aliases": ["mitochondria localization", "establishment and maintenance of mitochondria localization", "mitochondrion localisation", "localization of mitochondria", "localization of mitochondrion", "establishment and maintenance of mitochondrion localization", "mitochondrial localization"], "types": ["T038"], "canonical_name": "mitochondrion localization", "definition": "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. [GOC:ai]"}
{"concept_id": "C1657246", "aliases": ["protein poly(ADP-ribose) degradation", "protein poly(ADP-ribose) catabolism", "protein poly(ADP-ribose) hydrolysis", "poly(ADP-ribose) removal from protein", "protein poly(ADP-ribose) catabolic process", "removal of ADP-ribose from protein", "protein amino acid de-ADP-ribosylation"], "types": ["T044"], "canonical_name": "protein de-ADP-ribosylation", "definition": "The process of removing one or more ADP-ribose residues from a protein. [GOC:ai]"}
{"concept_id": "C1657247", "aliases": [], "types": ["T044"], "canonical_name": "thalianol synthase activity", "definition": "Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol). [PMID:15125655, RHEA:26160]"}
{"concept_id": "C1657248", "aliases": [], "types": ["T026"], "definition": "Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.", "canonical_name": "apoptosome"}
{"concept_id": "C1657249", "aliases": ["movement of symbiont within host", "movement within host", "movement of symbiont in host", "symbiont movement in host", "symbiont movement within host"], "types": ["T040"], "canonical_name": "movement in host", "definition": "The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1657250", "aliases": ["up regulation of bipolar cell growth", "up-regulation of bipolar cell growth", "upregulation of bipolar cell growth"], "types": ["T043"], "canonical_name": "positive regulation of bipolar cell growth", "definition": "Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. [GOC:ai]"}
{"concept_id": "C1657251", "aliases": ["downregulation of intermediate mesodermal cell fate determination", "down regulation of intermediate mesodermal cell fate determination", "down-regulation of intermediate mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "negative regulation of intermediate mesodermal cell fate determination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1657252", "aliases": ["positive regulation of SMC proliferation", "up-regulation of smooth muscle cell proliferation", "upregulation of smooth muscle cell proliferation", "up regulation of smooth muscle cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of smooth muscle cell proliferation", "definition": "Any process that activates or increases the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]"}
{"concept_id": "C1657253", "aliases": ["upregulation of sprouting of injured axon", "up regulation of sprouting of injured axon", "up-regulation of sprouting of injured axon"], "types": ["T042"], "canonical_name": "positive regulation of sprouting of injured axon", "definition": "Any process that activates, maintains or increases the rate of sprouting of an injured axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657277", "aliases": ["nasus morphogenesis"], "types": ["T042"], "canonical_name": "nose morphogenesis", "definition": "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). [GOC:jl]"}
{"concept_id": "C1657278", "aliases": ["protein amino acid autophosphorylation"], "types": ["T044"], "canonical_name": "protein autophosphorylation", "definition": "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]"}
{"concept_id": "C1657279", "aliases": [], "types": ["T044"], "canonical_name": "cell surface receptor ligand"}
{"concept_id": "C1657280", "aliases": ["tapetal cell differentiation"], "types": ["T043"], "canonical_name": "anther wall tapetum cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an anther cell wall tapetum cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. [GOC:jid, GOC:sm]"}
{"concept_id": "C1657281", "aliases": ["negative regulation of SMC proliferation", "down-regulation of smooth muscle cell proliferation", "down regulation of smooth muscle cell proliferation", "downregulation of smooth muscle cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of smooth muscle cell proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]"}
{"concept_id": "C1657282", "aliases": [], "types": ["T043"], "canonical_name": "collateral sprouting", "definition": "The process in which outgrowths develop from the shafts of existing axons. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657283", "aliases": ["up regulation of collateral sprouting", "upregulation of collateral sprouting", "up-regulation of collateral sprouting"], "types": ["T043"], "canonical_name": "positive regulation of collateral sprouting", "definition": "Any process that activates or increases the frequency, rate or extent of collateral sprouting. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657285", "aliases": [], "types": ["T040"], "canonical_name": "response to axon injury", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657286", "aliases": [], "types": ["T042"], "canonical_name": "sprouting of injured axon", "definition": "The process involved in sprouting of an injured axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657287", "aliases": ["up regulation of collateral sprouting of intact axon in response to injury", "upregulation of collateral sprouting of intact axon in response to injury", "up-regulation of collateral sprouting of intact axon in response to injury"], "types": ["T043"], "canonical_name": "positive regulation of collateral sprouting of intact axon in response to injury", "definition": "Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657289", "aliases": ["positive regulation of calcium ion (Ca2+) mobilization", "positive regulation of calcium mobilization", "positive regulation of release of sequestered calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "positive regulation of release of stored calcium ion (Ca2+)"}
{"concept_id": "C1657290", "aliases": ["4Fe-4S cluster binding", "tetrairon tetrasulphide cluster binding", "iron-sulphur cluster 4Fe-4S binding", "tetrairon tetrasulfide cluster binding", "iron-sulfur cluster 4Fe-4S binding", "4 Fe 4 S cluster binding", "4 iron, 4 sulphur cluster binding"], "types": ["T044"], "canonical_name": "4 iron, 4 sulfur cluster binding", "definition": "Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]"}
{"concept_id": "C1657291", "aliases": ["elastin metabolism"], "types": ["T044"], "canonical_name": "elastin metabolic process", "definition": "The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue. [GOC:curators]"}
{"concept_id": "C1657293", "aliases": [], "types": ["T043"], "canonical_name": "regulation of keratinocyte migration", "definition": "Any process that modulates the frequency, rate or extent of keratinocyte migration. [GOC:ai]"}
{"concept_id": "C1657294", "aliases": ["hydrolase inhibitor", "down-regulation of hydrolase activity", "downregulation of hydrolase activity", "negative regulation of hydrolase activity"], "types": ["T044"], "definition": "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. [GOC:ai]", "canonical_name": "down regulation of hydrolase activity"}
{"concept_id": "C1657295", "aliases": ["up-regulation of lyase activity", "upregulation of lyase activity", "lyase activator", "up regulation of lyase activity"], "types": ["T044"], "canonical_name": "positive regulation of lyase activity", "definition": "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:ai]"}
{"concept_id": "C1657296", "aliases": ["tRNA cytidine N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "tRNA N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA. [PMID:15037780]"}
{"concept_id": "C1657297", "aliases": [], "types": ["T039"], "canonical_name": "response to nitrosative stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. [PMID:15925705]"}
{"concept_id": "C1657298", "aliases": [], "types": ["T044"], "canonical_name": "BH2 domain binding", "definition": "Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01258]"}
{"concept_id": "C1657300", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid 6-desaturase activity"}
{"concept_id": "C1657301", "aliases": ["maintenance of Golgi body localization", "maintenance of Golgi localization", "maintenance of Golgi apparatus localization"], "types": ["T043"], "canonical_name": "maintenance of Golgi location", "definition": "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1657348", "aliases": ["passive viral activation of humoral immune response in host", "passive viral induction of humoral immune response in host", "passive induction of host humoral immune response by virus"], "types": ["T043"], "canonical_name": "passive induction of humoral immune response in host by virus"}
{"concept_id": "C1657350", "aliases": ["down-regulation of axial mesodermal cell fate specification", "downregulation of axial mesodermal cell fate specification", "down regulation of axial mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of axial mesodermal cell fate specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1657433", "aliases": ["embryonic skeletal morphogenesis"], "types": ["T040"], "canonical_name": "embryonic skeletal system morphogenesis", "definition": "The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]"}
{"concept_id": "C1657434", "aliases": [], "types": ["T040"], "canonical_name": "instar larval or pupal morphogenesis", "definition": "The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized. [GOC:mtg_sensu, GOC:rc]"}
{"concept_id": "C1657435", "aliases": [], "types": ["T043"], "canonical_name": "astrocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. [GOC:vp, PMID:15139015]"}
{"concept_id": "C1657436", "aliases": ["up-regulation of astrocyte differentiation", "upregulation of astrocyte differentiation", "up regulation of astrocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of astrocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. [GOC:vp, PMID:15139015]"}
{"concept_id": "C1657437", "aliases": [], "types": ["T043"], "canonical_name": "regulation of oligodendrocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. [GOC:vp, PMID:15139015]"}
{"concept_id": "C1657438", "aliases": [], "types": ["T042"], "canonical_name": "fish trap bristle morphogenesis"}
{"concept_id": "C1657439", "aliases": [], "types": ["T042"], "canonical_name": "anterior cibarial plate development", "definition": "The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure. [GOC:rc]"}
{"concept_id": "C1657441", "aliases": [], "types": ["T042"], "canonical_name": "posterior cibarial plate development", "definition": "The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure. [GOC:rc]"}
{"concept_id": "C1657442", "aliases": [], "types": ["T042"], "canonical_name": "tissue morphogenesis", "definition": "The process in which the anatomical structures of a tissue are generated and organized. [GOC:dph, GOC:jid]"}
{"concept_id": "C1657443", "aliases": [], "types": ["T040"], "canonical_name": "imaginal disc-derived appendage development", "definition": "The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism. [GOC:jid, GOC:mtg_sensu, GOC:rc]"}
{"concept_id": "C1657444", "aliases": ["regulation of skeletal myofiber development", "regulation of skeletal muscle fibre development", "regulation of skeletal myofibre development"], "types": ["T042"], "canonical_name": "regulation of skeletal muscle fiber development", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm]"}
{"concept_id": "C1657445", "aliases": ["protein homotetramer assembly", "protein homotetramer formation", "protein homotetramer biosynthetic process", "protein homotetramer biosynthesis"], "types": ["T044"], "canonical_name": "protein homotetramerization", "definition": "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators]"}
{"concept_id": "C1657446", "aliases": ["protein heterooligomer assembly", "protein heterooligomer biosynthetic process", "protein heterooligomer biosynthesis", "protein heterooligomer formation"], "types": ["T044"], "canonical_name": "protein heterooligomerization", "definition": "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai]"}
{"concept_id": "C1657447", "aliases": ["nuclear pore complex biogenesis", "nuclear pore assembly", "nuclear pore biosynthesis", "NPC assembly", "nuclear pore formation", "nuclear pore complex formation", "nuclear pore complex biosynthesis", "nuclear pore biogenesis"], "types": ["T043"], "canonical_name": "nuclear pore complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. [GOC:ai, GOC:mah]"}
{"concept_id": "C1657448", "aliases": [], "types": ["T044"], "canonical_name": "2-phenylchromone metabolism"}
{"concept_id": "C1657450", "aliases": ["phlobaphene metabolism"], "types": ["T044"], "canonical_name": "phlobaphene metabolic process", "definition": "The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols. [PMID:11402179]"}
{"concept_id": "C1657451", "aliases": ["extrinsic to internal side of cell outer membrane", "extrinsic to internal side of outer membrane", "extrinsic to periplasmic side of cell outer membrane"], "types": ["T026"], "canonical_name": "extrinsic component of periplasmic side of cell outer membrane", "definition": "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1657453", "aliases": ["extrinsic to mitochondrial inner membrane"], "types": ["T026"], "canonical_name": "extrinsic component of mitochondrial inner membrane", "definition": "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]"}
{"concept_id": "C1657454", "aliases": ["regulation of phosphoinositide 3-kinase activity"], "types": ["T044"], "canonical_name": "regulation of phosphatidylinositol 3-kinase activity", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. [GOC:bf]"}
{"concept_id": "C1657456", "aliases": ["positive regulation of cellular physiological process", "up-regulation of cellular process", "upregulation of cellular process", "up regulation of cellular process"], "types": ["T043"], "canonical_name": "positive regulation of cellular process", "definition": "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:jid]"}
{"concept_id": "C1657457", "aliases": [], "types": ["T040"], "canonical_name": "establishment of anatomical structure orientation", "definition": "The process that determines the orientation of an anatomical structure with reference to an axis. [GOC:jid]"}
{"concept_id": "C1657458", "aliases": [], "types": ["T042"], "canonical_name": "sensory perception of light stimulus", "definition": "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]"}
{"concept_id": "C1657459", "aliases": ["positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity", "upregulation of cyclic nucleotide phosphodiesterase activity", "up regulation of cyclic nucleotide phosphodiesterase activity", "positive regulation of cyclic nucleotide phosphodiesterase activity", "up-regulation of cyclic nucleotide phosphodiesterase activity", "3',5' cyclic nucleotide phosphodiesterase activator"], "types": ["T044"], "canonical_name": "positive regulation of cyclic-nucleotide phosphodiesterase activity", "definition": "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. [GOC:ai, GOC:tb]"}
{"concept_id": "C1657574", "aliases": [], "types": ["T040"], "canonical_name": "entry into host through host barriers"}
{"concept_id": "C1657575", "aliases": ["transport of DNA into host"], "types": ["T043"], "canonical_name": "translocation of DNA into host", "definition": "The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1657578", "aliases": [], "types": ["T042"], "canonical_name": "sieve cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. [GOC:jid, PO:0025415, POC:curators]"}
{"concept_id": "C1657579", "aliases": ["spindle positioning", "establishment of spindle localisation"], "types": ["T043"], "canonical_name": "establishment of spindle localization", "definition": "The directed movement of the spindle to a specific location in the cell. [GOC:ai]"}
{"concept_id": "C1657580", "aliases": ["orienting of spindle", "spindle orientation"], "types": ["T043"], "canonical_name": "establishment of spindle orientation", "definition": "Any process that set the alignment of spindle relative to other cellular structures. [GOC:ai]"}
{"concept_id": "C1657581", "aliases": ["sister chromatid separation during mitosis", "mitotic sister chromatid resolution"], "types": ["T043"], "canonical_name": "mitotic sister chromatid separation", "definition": "The process in which sister chromatids are physically detached from each other during mitosis. [GOC:ai]"}
{"concept_id": "C1657582", "aliases": ["chromosome separation during mitosis"], "types": ["T043"], "canonical_name": "mitotic chromosome separation"}
{"concept_id": "C1657583", "aliases": [], "types": ["T045"], "canonical_name": "microtubule and chromosome interaction"}
{"concept_id": "C1657584", "aliases": ["up-regulation of histone H3-K4 methylation", "up regulation of histone H3-K4 methylation", "upregulation of histone H3-K4 methylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K4 methylation", "definition": "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. [GOC:mah]"}
{"concept_id": "C1657585", "aliases": ["up regulation of histone H3-K9 methylation", "up-regulation of histone H3-K9 methylation", "upregulation of histone H3-K9 methylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K9 methylation", "definition": "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. [GOC:ai]"}
{"concept_id": "C1657586", "aliases": ["up-regulation of neurotransmitter uptake", "up regulation of neurotransmitter uptake", "upregulation of neurotransmitter uptake", "positive regulation of neurotransmitter import"], "types": ["T043"], "canonical_name": "positive regulation of neurotransmitter uptake", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C1657587", "aliases": [], "types": ["T043"], "canonical_name": "dopamine uptake", "definition": "The directed movement of dopamine into a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C1657588", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neurotransmitter transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1657589", "aliases": ["response to cyclic AMP", "response to 3',5' cAMP", "response to 3',5'-cAMP", "response to adenosine 3',5'-cyclophosphate"], "types": ["T043"], "canonical_name": "response to cAMP", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:ai]"}
{"concept_id": "C1657590", "aliases": [], "types": ["T026"], "canonical_name": "plasma membrane, GPI-anchored"}
{"concept_id": "C1657592", "aliases": ["establishment and maintenance of vesicle localization", "cytoplasmic vesicle localization", "vesicle localisation"], "types": ["T038"], "canonical_name": "vesicle localization", "definition": "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. [GOC:ai]"}
{"concept_id": "C1657605", "aliases": ["meiotic cell cycle"], "types": ["T043"], "definition": "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. [GOC:ai]", "canonical_name": "meiosis"}
{"concept_id": "C1657606", "aliases": ["interphase of mitotic cell cycle"], "types": ["T043"], "canonical_name": "mitotic interphase", "definition": "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1657607", "aliases": ["G2 phase of meiotic cell cycle"], "types": ["T043"], "canonical_name": "meiotic G2 phase", "definition": "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1657608", "aliases": [], "types": ["T043"], "canonical_name": "meiotic nuclear envelope reassembly"}
{"concept_id": "C1657609", "aliases": ["hydrolase regulator"], "types": ["T044"], "canonical_name": "regulation of hydrolase activity", "definition": "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. [GOC:ai]"}
{"concept_id": "C1657610", "aliases": ["positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity"], "types": ["T044"], "canonical_name": "positive regulation of cAMP phosphodiesterase activity"}
{"concept_id": "C1657611", "aliases": ["response to static fluid pressure"], "types": ["T039"], "canonical_name": "response to hydrostatic pressure", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. [Wikipedia:Hydrostatic_pressure]"}
{"concept_id": "C1657613", "aliases": ["establishment and maintenance of exocyst localization", "exocyst localisation"], "types": ["T043"], "canonical_name": "exocyst localization", "definition": "Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. [GOC:ai]"}
{"concept_id": "C1657614", "aliases": ["stimulus detection"], "types": ["T044"], "canonical_name": "detection of stimulus", "definition": "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. [GOC:add, GOC:ai, GOC:dph, GOC:mah]"}
{"concept_id": "C1657615", "aliases": [], "types": ["T043"], "canonical_name": "histamine transport", "definition": "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]"}
{"concept_id": "C1657616", "aliases": ["positive regulation of 5-HT uptake", "positive regulation of 5HT uptake", "up regulation of serotonin uptake", "upregulation of serotonin uptake", "up-regulation of serotonin uptake", "positive regulation of serotonin import", "positive regulation of 5-hydroxytryptamine uptake"], "types": ["T043"], "canonical_name": "positive regulation of serotonin uptake", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell. [GOC:ai]"}
{"concept_id": "C1657617", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myelination", "definition": "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah]"}
{"concept_id": "C1657618", "aliases": ["sensory perception of pain, sensory detection of thermal stimulus", "sensory perception of pain, sensory transduction of thermal stimulus", "sensory detection of thermal stimulus during sensory perception of pain", "perception of pain, sensory transduction of temperature stimulus", "perception of pain, detection of temperature stimulus", "perception of pain, sensory detection of temperature stimulus", "sensory transduction of thermal stimulus during sensory perception of pain", "sensory detection of temperature stimulus during perception of pain", "sensory transduction of temperature stimulus during perception of pain"], "types": ["T040"], "canonical_name": "detection of temperature stimulus involved in sensory perception of pain", "definition": "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]"}
{"concept_id": "C1657619", "aliases": ["down regulation of lyase activity", "down-regulation of lyase activity", "downregulation of lyase activity", "lyase inhibitor"], "types": ["T044"], "canonical_name": "negative regulation of lyase activity", "definition": "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:ai]"}
{"concept_id": "C1657726", "aliases": ["active viral induction of humoral immune response in host", "active induction of humoral immune response in host by virus"], "types": ["T043"], "canonical_name": "induction of humoral immune response in host by virus", "definition": "The intentional, virally-encoded stimulation of a host humoral defense response to viral infection. [GOC:jl]"}
{"concept_id": "C1657727", "aliases": ["up-regulation of post-embryonic development", "up regulation of post-embryonic development", "upregulation of post-embryonic development"], "types": ["T039"], "canonical_name": "positive regulation of post-embryonic development", "definition": "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. [GOC:jid]"}
{"concept_id": "C1657728", "aliases": ["down regulation of response to stimulus", "down-regulation of response to stimulus", "downregulation of response to stimulus"], "types": ["T039"], "canonical_name": "negative regulation of response to stimulus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. [GOC:jid]"}
{"concept_id": "C1657729", "aliases": [], "types": ["T040"], "canonical_name": "regulation of long-day photoperiodism, flowering", "definition": "Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1657730", "aliases": [], "types": ["T040"], "canonical_name": "regulation of short-day photoperiodism, flowering", "definition": "Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]"}
{"concept_id": "C1657731", "aliases": [], "types": ["T043"], "canonical_name": "oocyte development", "definition": "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. [GOC:go_curators]"}
{"concept_id": "C1657732", "aliases": ["FGF 2 binding"], "types": ["T044"], "canonical_name": "fibroblast growth factor 2 binding"}
{"concept_id": "C1657733", "aliases": [], "types": ["T040"], "canonical_name": "reproductive structure development", "definition": "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. [GOC:dph, GOC:isa_complete, GOC:jid]"}
{"concept_id": "C1657735", "aliases": ["post-embryonic ectodermal gut morphogenesis"], "types": ["T042"], "canonical_name": "post-embryonic ectodermal digestive tract morphogenesis", "definition": "The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. [GOC:jid, GOC:rc]"}
{"concept_id": "C1657736", "aliases": [], "types": ["T026"], "canonical_name": "APC activator"}
{"concept_id": "C1657737", "aliases": ["down regulation of cytoskeleton organization", "negative regulation of cytoskeleton organisation", "downregulation of cytoskeleton organization", "inhibition of cytoskeleton organization", "negative regulation of cytoskeleton organization and biogenesis", "down-regulation of cytoskeleton organization"], "types": ["T043"], "canonical_name": "negative regulation of cytoskeleton organization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:ai]"}
{"concept_id": "C1657738", "aliases": [], "types": ["T044"], "canonical_name": "D-tyrosyl-tRNA(Tyr) deacylase activity", "definition": "Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA. [PMID:14527667]"}
{"concept_id": "C1657739", "aliases": ["diterpene phytoalexin precursor formation pathway", "diterpene phytoalexin precursor synthesis pathway", "diterpene phytoalexin precursor anabolism pathway"], "types": ["T044"], "canonical_name": "diterpene phytoalexin precursor biosynthetic process pathway", "definition": "A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins. [MetaCyc:PWY-2981]"}
{"concept_id": "C1657740", "aliases": [], "types": ["T040"], "canonical_name": "entry into other organism involved in symbiotic interaction"}
{"concept_id": "C1657749", "aliases": ["sensory perception, sensory detection of heat stimulus"], "types": ["T038"], "canonical_name": "sensory detection of heat stimulus during sensory perception"}
{"concept_id": "C1657777", "aliases": [], "types": ["T042"], "canonical_name": "embryonic hindgut morphogenesis", "definition": "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase. [GOC:jid, GOC:rc]"}
{"concept_id": "C1657779", "aliases": [], "types": ["T043"], "canonical_name": "myoblast fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:dph, GOC:mtg_muscle]"}
{"concept_id": "C1657780", "aliases": [], "types": ["T043"], "canonical_name": "myoblast maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:dph, GOC:mtg_muscle]"}
{"concept_id": "C1657784", "aliases": ["up-regulation of developmental growth", "upregulation of developmental growth", "up regulation of developmental growth"], "types": ["T040"], "canonical_name": "positive regulation of developmental growth", "definition": "Any process that activates, maintains or increases the rate of developmental growth. [GOC:go_curators]"}
{"concept_id": "C1657786", "aliases": [], "types": ["T038"], "canonical_name": "anther morphogenesis", "definition": "The process in which the anatomical structures of the anther are generated and organized. [GOC:jid, GOC:sm]"}
{"concept_id": "C1657787", "aliases": ["tapetal layer formation", "tapetum formation"], "types": ["T039"], "canonical_name": "anther wall tapetum formation", "definition": "The process that gives rise to the anther wall tapetum. This process pertains to the initial formation of a structure from unspecified parts. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. [GOC:jid, GOC:sm, GOC:tb]"}
{"concept_id": "C1657788", "aliases": ["addition of ethanolamine phosphate to mannose of GPI precursor CP2", "gpi7 activity", "CP2 EtN-P transferase activity", "CP2 phosphoethanolamine transferase activity"], "types": ["T044"], "canonical_name": "CP2 mannose-ethanolamine phosphotransferase activity", "definition": "Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2. [PMID:14985347, PMID:15452134]"}
{"concept_id": "C1657790", "aliases": [], "types": ["T044"], "canonical_name": "beta-sitosterol UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol. [GOC:ai, RHEA:61832]"}
{"concept_id": "C1657791", "aliases": [], "types": ["T044"], "canonical_name": "tomatidine UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + tomatidine = UDP + O-glucosyl-tomatidine. [GOC:ai]"}
{"concept_id": "C1657792", "aliases": ["down regulation of unidimensional cell growth", "downregulation of unidimensional cell growth", "down-regulation of unidimensional cell growth"], "types": ["T043"], "canonical_name": "negative regulation of unidimensional cell growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis. [GOC:ai]"}
{"concept_id": "C1657793", "aliases": [], "types": ["T043"], "canonical_name": "regulation of monopolar cell growth", "definition": "Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. [GOC:ai]"}
{"concept_id": "C1657794", "aliases": ["downregulation of bipolar cell growth", "down-regulation of bipolar cell growth", "down regulation of bipolar cell growth"], "types": ["T043"], "canonical_name": "negative regulation of bipolar cell growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. [GOC:ai]"}
{"concept_id": "C1657795", "aliases": [], "types": ["T043"], "canonical_name": "activation of monopolar cell growth", "definition": "Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell. [GOC:ai]"}
{"concept_id": "C1657796", "aliases": ["NFATc2 binding", "NFATp binding"], "types": ["T045"], "canonical_name": "NFAT1 protein binding"}
{"concept_id": "C1657797", "aliases": ["NFATc4 binding"], "types": ["T045"], "canonical_name": "NFAT3 protein binding"}
{"concept_id": "C1657942", "aliases": [], "types": ["T045"], "canonical_name": "NFATc3 binding"}
{"concept_id": "C1657943", "aliases": ["NFAT5 protein binding"], "types": ["T045"], "canonical_name": "non-calcium-regulated NFAT protein binding"}
{"concept_id": "C1657946", "aliases": ["up-regulation of cardioblast differentiation", "upregulation of cardioblast differentiation", "up regulation of cardioblast differentiation"], "types": ["T043"], "canonical_name": "positive regulation of cardioblast differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:ai]"}
{"concept_id": "C1657947", "aliases": ["downregulation of cardioblast differentiation", "down-regulation of cardioblast differentiation", "down regulation of cardioblast differentiation"], "types": ["T043"], "canonical_name": "negative regulation of cardioblast differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:ai]"}
{"concept_id": "C1657948", "aliases": ["regulation of AKT signalling cascade", "regulation of PKB signaling cascade", "regulation of PKB signalling cascade", "regulation of AKT signaling cascade", "regulation of protein kinase B signalling cascade", "regulation of protein kinase B signaling cascade"], "types": ["T044"], "canonical_name": "regulation of protein kinase B signaling", "definition": "Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. [GOC:ai]"}
{"concept_id": "C1657949", "aliases": ["positive regulation of AKT signaling cascade", "positive regulation of PKB signaling cascade", "positive regulation of protein kinase B signalling cascade", "upregulation of protein kinase B signaling cascade", "up regulation of protein kinase B signaling cascade", "positive regulation of protein kinase B signaling cascade", "positive regulation of PKB signalling cascade", "positive regulation of AKT signalling cascade", "up-regulation of protein kinase B signaling cascade"], "types": ["T044"], "canonical_name": "positive regulation of protein kinase B signaling", "definition": "Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. [GOC:ai]"}
{"concept_id": "C1657950", "aliases": ["plus-end F-actin uncapping", "barbed-end F-actin uncapping", "plus-end actin filament uncapping", "plus end F-actin uncapping", "plus end actin filament uncapping", "barbed end actin filament uncapping", "barbed end F-actin uncapping"], "types": ["T043"], "canonical_name": "barbed-end actin filament uncapping", "definition": "The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. [GOC:pf]"}
{"concept_id": "C1657954", "aliases": [], "types": ["T044"], "canonical_name": "regulation of generation of precursor metabolites and energy", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. [GOC:jl]"}
{"concept_id": "C1657984", "aliases": ["nasus development"], "types": ["T042"], "canonical_name": "nose development", "definition": "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). [GOC:jl]"}
{"concept_id": "C1657986", "aliases": [], "types": ["T043"], "canonical_name": "neuron fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:dph]"}
{"concept_id": "C1657987", "aliases": [], "types": ["T043"], "canonical_name": "neuron development", "definition": "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dph]"}
{"concept_id": "C1657989", "aliases": [], "types": ["T043"], "canonical_name": "regulation of collateral sprouting", "definition": "Any process that modulates the frequency, rate or extent of collateral sprouting. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657990", "aliases": [], "types": ["T042"], "canonical_name": "collateral sprouting of intact axon in response to injury", "definition": "The process in which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input. [GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1657991", "aliases": ["down-regulation of axon regeneration", "down regulation of axon regeneration", "downregulation of axon regeneration"], "types": ["T042"], "canonical_name": "negative regulation of axon regeneration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657993", "aliases": [], "types": ["T043"], "canonical_name": "regulation of collateral sprouting of injured axon", "definition": "Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657994", "aliases": ["up regulation of collateral sprouting of injured axon", "up-regulation of collateral sprouting of injured axon", "upregulation of collateral sprouting of injured axon"], "types": ["T043"], "canonical_name": "positive regulation of collateral sprouting of injured axon", "definition": "Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657995", "aliases": ["downregulation of collateral sprouting of injured axon", "down regulation of collateral sprouting of injured axon", "down-regulation of collateral sprouting of injured axon"], "types": ["T043"], "canonical_name": "negative regulation of collateral sprouting of injured axon", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an injured axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657996", "aliases": ["upregulation of collateral sprouting in the absence of injury", "up regulation of collateral sprouting in the absence of injury", "up-regulation of collateral sprouting in the absence of injury"], "types": ["T043"], "canonical_name": "positive regulation of collateral sprouting in absence of injury", "definition": "Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1657997", "aliases": ["embryonic cranium morphogenesis"], "types": ["T040"], "canonical_name": "embryonic cranial skeleton morphogenesis", "definition": "The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. [GOC:dsf, GOC:jid, PMID:16049113]"}
{"concept_id": "C1657998", "aliases": ["cell wall polysaccharide anabolism", "chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process", "fungal-type cell wall polysaccharide biosynthetic process", "cell wall polysaccharide synthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall. [GOC:ai, GOC:mtg_sensu]", "canonical_name": "cell wall polysaccharide formation"}
{"concept_id": "C1657999", "aliases": ["negative regulation of cytoplasmic release of stored calcium ion (Ca2+)", "negative regulation of release of sequestered calcium ion into cytoplasm", "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm"}
{"concept_id": "C1658000", "aliases": ["negative regulation of calcium ion (Ca2+) retention", "negative regulation of calcium ion (Ca2+) sequestering", "negative regulation of calcium ion (Ca2+) sequestration", "downregulation of sequestering of calcium ion", "down-regulation of sequestering of calcium ion", "negative regulation of retention of calcium ion (Ca2+)", "negative regulation of calcium ion (Ca2+) storage", "down regulation of sequestering of calcium ion", "negative regulation of sequestering of calcium ion (Ca2+)", "negative regulation of storage of calcium ion (Ca2+)", "negative regulation of sequestration of calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "negative regulation of sequestering of calcium ion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. [GOC:ai]"}
{"concept_id": "C1658001", "aliases": [], "types": ["T044"], "canonical_name": "syntaxin-5 binding"}
{"concept_id": "C1658002", "aliases": [], "types": ["T044"], "canonical_name": "metal cluster binding", "definition": "Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. [GOC:jsg]"}
{"concept_id": "C1658004", "aliases": ["benzalcoumaran-3-one biosynthetic process", "benzalcoumaran-3-one biosynthesis"], "types": ["T044"], "canonical_name": "aurone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments. [GOC:ai, PMID:20035037]"}
{"concept_id": "C1658005", "aliases": [], "types": ["T044"], "canonical_name": "2-phenyl-4H-1-benzopyran-4-one metabolism"}
{"concept_id": "C1658006", "aliases": ["coenzyme Q6 metabolism", "coenzyme Q6 metabolic process", "ubiquinone-6 metabolism"], "types": ["T044"], "canonical_name": "ubiquinone-6 metabolic process", "definition": "The chemical reactions and pathways involving ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2. [GOC:al, GOC:TermGenie, PMID:1409592]"}
{"concept_id": "C1658008", "aliases": ["G1 phase of meiotic cell cycle"], "types": ["T079"], "canonical_name": "meiotic G1 phase", "definition": "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1658009", "aliases": ["calsarcin 1 binding", "filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle", "calsarcin binding", "FATZ 2 binding", "calsarcin 2 binding", "calsarcin 3 binding", "FATZ 3 binding", "FATZ 1 binding"], "types": ["T044"], "canonical_name": "FATZ binding", "definition": "Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. [PMID:10984498, PMID:11699871]"}
{"concept_id": "C1658010", "aliases": ["polypeptide hormone receptor binding"], "types": ["T044"], "canonical_name": "peptide hormone receptor binding", "definition": "Binding to a receptor for a peptide hormone. [GOC:ai]"}
{"concept_id": "C1658011", "aliases": ["glucose detection"], "types": ["T043"], "canonical_name": "detection of glucose", "definition": "The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal. [GOC:ai]"}
{"concept_id": "C1658012", "aliases": ["polynucleotide 5'-hydroxyl kinase (phosphorylating) activity", "5'-hydroxyl polynucleotide kinase activity", "PNK", "polynucleotide 5'-hydroxy-kinase activity", "5'-dephosphopolynucleotide kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. [GOC:curators]", "canonical_name": "polynucleotide 5'-hydroxyl-kinase activity"}
{"concept_id": "C1658108", "aliases": ["down-regulation of oligodendrocyte differentiation", "down regulation of oligodendrocyte differentiation", "downregulation of oligodendrocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of oligodendrocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. [GOC:vp, PMID:15139015]"}
{"concept_id": "C1658109", "aliases": [], "types": ["T042"], "canonical_name": "labrum morphogenesis", "definition": "The process in which the anatomical structures of labrum are generated and organized. [GOC:rc]"}
{"concept_id": "C1658110", "aliases": [], "types": ["T042"], "canonical_name": "anterior cibarial plate morphogenesis", "definition": "The process in which the anatomical structures of the anterior cibarial plate are generated and organized. [GOC:rc]"}
{"concept_id": "C1658111", "aliases": [], "types": ["T042"], "canonical_name": "epistomal sclerite morphogenesis", "definition": "The process in which the anatomical structures of the epistomal sclerite are generated and organized. [GOC:rc]"}
{"concept_id": "C1658112", "aliases": [], "types": ["T040"], "canonical_name": "appendage development", "definition": "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. [GOC:jid, GOC:rc]"}
{"concept_id": "C1658113", "aliases": ["nicotinamide adenine dinucleotide binding"], "types": ["T044"], "definition": "Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai]", "canonical_name": "NAD binding"}
{"concept_id": "C1658115", "aliases": [], "types": ["T044"], "canonical_name": "2-phenylchromone biosynthesis"}
{"concept_id": "C1658117", "aliases": ["down regulation of cell projection organization", "downregulation of cell projection organization", "negative regulation of cell projection organisation", "negative regulation of cell projection organization and biogenesis", "inhibition of cell projection organization", "down-regulation of cell projection organization"], "types": ["T043"], "canonical_name": "negative regulation of cell projection organization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. [GOC:mah]"}
{"concept_id": "C1658118", "aliases": ["intrinsic to thylakoid membrane"], "types": ["T026"], "canonical_name": "intrinsic component of thylakoid membrane", "definition": "The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1658119", "aliases": [], "types": ["T044"], "canonical_name": "GTP:hexose-1-phosphate guanylyltransferase activity"}
{"concept_id": "C1658120", "aliases": [], "types": ["T043"], "canonical_name": "plastid fission", "definition": "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. [GOC:jl]"}
{"concept_id": "C1658121", "aliases": ["regulation of lateral plate mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "regulation of lateral mesodermal cell fate specification", "definition": "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification. [GOC:jid]"}
{"concept_id": "C1658122", "aliases": ["chromosome congression"], "types": ["T045"], "canonical_name": "metaphase plate congression", "definition": "The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle. [GOC:ai]"}
{"concept_id": "C1658123", "aliases": ["ligase activator", "up regulation of ligase activity", "upregulation of ligase activity", "up-regulation of ligase activity"], "types": ["T044"], "canonical_name": "positive regulation of ligase activity", "definition": "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. [GOC:ai]"}
{"concept_id": "C1658136", "aliases": ["avoidance of host defences"], "types": ["T040"], "canonical_name": "avoidance of host defenses"}
{"concept_id": "C1658138", "aliases": ["transport of molecules into host"], "types": ["T043"], "canonical_name": "translocation of molecules into host", "definition": "The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1658139", "aliases": ["up regulation of skeletal muscle fiber development", "upregulation of skeletal muscle fiber development", "up-regulation of skeletal muscle fiber development", "positive regulation of skeletal muscle fibre development", "positive regulation of skeletal myofibre development", "positive regulation of skeletal myofiber development"], "types": ["T040"], "canonical_name": "positive regulation of skeletal muscle fiber development", "definition": "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]"}
{"concept_id": "C1658140", "aliases": ["negative regulation of skeletal muscle fibre development", "down regulation of skeletal muscle fiber development", "negative regulation of skeletal myofiber development", "down-regulation of skeletal muscle fiber development", "negative regulation of skeletal myofibre development", "downregulation of skeletal muscle fiber development"], "types": ["T040"], "canonical_name": "negative regulation of skeletal muscle fiber development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]"}
{"concept_id": "C1658141", "aliases": ["insect-type retina development"], "types": ["T042"], "canonical_name": "compound eye development", "definition": "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]"}
{"concept_id": "C1658142", "aliases": ["embryonic semicircular canal morphogenesis"], "types": ["T042"], "canonical_name": "semicircular canal morphogenesis", "definition": "The process in which the anatomical structures of the semicircular canals are generated and organized. [GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1658143", "aliases": [], "types": ["T042"], "canonical_name": "tubulogenesis"}
{"concept_id": "C1658144", "aliases": [], "types": ["T042"], "canonical_name": "branching morphogenesis of a nerve", "definition": "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). [GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1658145", "aliases": [], "types": ["T045"], "canonical_name": "chromosome separation", "definition": "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243]"}
{"concept_id": "C1658146", "aliases": ["chromosome migration to spindle pole", "chromosome movement to spindle pole"], "types": ["T045"], "canonical_name": "chromosome movement towards spindle pole", "definition": "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes. [GOC:ai]"}
{"concept_id": "C1658147", "aliases": ["down regulation of histone H3-K9 methylation", "downregulation of histone H3-K9 methylation", "down-regulation of histone H3-K9 methylation"], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K9 methylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. [GOC:ai]"}
{"concept_id": "C1658148", "aliases": [], "types": ["T044"], "canonical_name": "dRPase activity"}
{"concept_id": "C1658149", "aliases": ["negative regulation of neurotransmitter import", "down regulation of neurotransmitter uptake", "down-regulation of neurotransmitter uptake", "downregulation of neurotransmitter uptake"], "types": ["T043"], "canonical_name": "negative regulation of neurotransmitter uptake", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C1658150", "aliases": ["glucose perception"], "types": ["T043"], "canonical_name": "glucose sensing"}
{"concept_id": "C1658151", "aliases": ["down-regulation of protein ubiquitination", "downregulation of protein ubiquitination", "down regulation of protein ubiquitination"], "types": ["T044"], "canonical_name": "negative regulation of protein ubiquitination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]"}
{"concept_id": "C1658152", "aliases": [], "types": ["T045"], "canonical_name": "myogenin binding"}
{"concept_id": "C1658153", "aliases": ["positive regulation of acetylcholine import", "up-regulation of acetylcholine uptake", "upregulation of acetylcholine uptake", "up regulation of acetylcholine uptake"], "types": ["T043"], "canonical_name": "positive regulation of acetylcholine uptake", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell. [GOC:ai]"}
{"concept_id": "C1658154", "aliases": ["establishment of vesicle localisation"], "types": ["T043"], "canonical_name": "establishment of vesicle localization", "definition": "The directed movement of a vesicle to a specific location. [GOC:ai]"}
{"concept_id": "C1658155", "aliases": [], "types": ["T043"], "canonical_name": "positioning within membrane"}
{"concept_id": "C1658400", "aliases": ["vegetative vivipary"], "types": ["T040"], "canonical_name": "plantlet formation on parent plant", "definition": "The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed. [GOC:go_curators]"}
{"concept_id": "C1658406", "aliases": [], "types": ["T067"], "canonical_name": "polyphenic determination", "definition": "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues. [GOC:jid]"}
{"concept_id": "C1658407", "aliases": [], "types": ["T067"], "canonical_name": "caste determination", "definition": "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. [GOC:jid]"}
{"concept_id": "C1658408", "aliases": [], "types": ["T067"], "canonical_name": "caste determination, influence by genetic factors", "definition": "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. [GOC:jid]"}
{"concept_id": "C1658409", "aliases": [], "types": ["T067"], "canonical_name": "caste determination, influence by environmental factors", "definition": "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. [GOC:jid]"}
{"concept_id": "C1658410", "aliases": [], "types": ["T067"], "canonical_name": "polyphenic determination, influence by environmental factors", "definition": "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues. [GOC:jid]"}
{"concept_id": "C1658411", "aliases": ["tapetal layer morphogenesis", "tapetum morphogenesis"], "types": ["T039"], "canonical_name": "anther wall tapetum morphogenesis", "definition": "The process in which the anatomical structures of the anther wall tapetum are generated and organized. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. [GOC:jid, GOC:sm, GOC:tb]"}
{"concept_id": "C1658412", "aliases": ["ethanolamine phosphate transferase activity", "EtN-P transferase activity", "phosphoethanolamine transferase activity", "addition of ethanolamine phosphate to mannose of GPI precursor", "CP2 ethanolamine phosphate transferase activity"], "types": ["T044"], "canonical_name": "mannose-ethanolamine phosphotransferase activity", "definition": "Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor. [PMID:15632136]"}
{"concept_id": "C1658413", "aliases": [], "types": ["T044"], "canonical_name": "ergosterol UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + ergosterol = UDP + O-glucosyl-ergosterol. [GOC:ai, RHEA:61836]"}
{"concept_id": "C1658414", "aliases": [], "types": ["T043"], "canonical_name": "regulation of unidimensional cell growth", "definition": "Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis. [GOC:ai]"}
{"concept_id": "C1658415", "aliases": ["up regulation of monopolar cell growth", "upregulation of monopolar cell growth", "up-regulation of monopolar cell growth"], "types": ["T043"], "canonical_name": "positive regulation of monopolar cell growth", "definition": "Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. [GOC:ai]"}
{"concept_id": "C1658417", "aliases": [], "types": ["T043"], "canonical_name": "termination of monopolar cell growth", "definition": "Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell. [GOC:ai]"}
{"concept_id": "C1658418", "aliases": [], "types": ["T043"], "canonical_name": "cell growth mode switching, monopolar to bipolar", "definition": "The process in which a cell switches from monopolar cell growth to bipolar cell growth. [GOC:ai]"}
{"concept_id": "C1658421", "aliases": ["transport of molecules into symbiont"], "types": ["T044"], "canonical_name": "translocation of molecules into symbiont", "definition": "The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1658423", "aliases": ["downregulation of anagen", "down-regulation of anagen", "down regulation of anagen"], "types": ["T040"], "canonical_name": "negative regulation of anagen"}
{"concept_id": "C1658424", "aliases": [], "types": ["T040"], "canonical_name": "regulation of exogen"}
{"concept_id": "C1658425", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardioblast differentiation", "definition": "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:ai]"}
{"concept_id": "C1658426", "aliases": ["inhibition of 5-hydroxytryptamine uptake", "inhibition of 5-HT uptake", "inhibition of serotonin import", "inhibition of 5HT uptake"], "types": ["T043"], "canonical_name": "inhibition of serotonin uptake", "definition": "Any process that prevents the activation of the directed movement of serotonin into a cell. [GOC:ai]"}
{"concept_id": "C1658427", "aliases": ["establishment of mitochondria localization", "mitochondrion positioning", "establishment of mitochondrion localisation", "positioning of mitochondria", "mitochondria positioning", "mitochondrial migration"], "types": ["T043"], "canonical_name": "establishment of mitochondrion localization", "definition": "The directed movement of the mitochondrion to a specific location. [GOC:ai]"}
{"concept_id": "C1658428", "aliases": ["polysaccharide beta-fructofuranosidase activity", "exo-beta-D-fructosidase activity", "fructan exohydrolase activity", "fructanase activity", "beta-D-fructan fructohydrolase activity", "exo-beta-fructosidase activity", "fructan b-fructosidase activity"], "types": ["T044"], "canonical_name": "fructan beta-fructosidase activity", "definition": "Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans. [EC:3.2.1.80]"}
{"concept_id": "C1658429", "aliases": ["minus-end actin filament capping activity", "pointed-end F-actin capping activity", "pointed-end actin capping activity", "minus-end F-actin capping activity"], "types": ["T043"], "canonical_name": "pointed-end actin filament capping", "definition": "The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. [ISBN:071673706X]"}
{"concept_id": "C1658431", "aliases": ["up regulation of blood vessel endothelial cell migration", "upregulation of blood vessel endothelial cell migration", "up-regulation of blood vessel endothelial cell migration"], "types": ["T043"], "canonical_name": "positive regulation of blood vessel endothelial cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]"}
{"concept_id": "C1658433", "aliases": ["thyrotropin releasing hormone binding"], "types": ["T044"], "canonical_name": "thyrotropin-releasing hormone binding", "definition": "Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system. [GOC:ai]"}
{"concept_id": "C1658434", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pinocytosis", "definition": "Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. [GOC:go_curators]"}
{"concept_id": "C1658435", "aliases": [], "types": ["T042"], "canonical_name": "animal organ formation", "definition": "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. [GOC:dph, GOC:jid]"}
{"concept_id": "C1658578", "aliases": ["SMC proliferation"], "types": ["T043"], "canonical_name": "smooth muscle cell proliferation", "definition": "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. [CL:0000192, GOC:ebc, PMID:1840698]"}
{"concept_id": "C1658579", "aliases": ["neuron lineage restriction", "neuronal lineage restriction"], "types": ["T043"], "canonical_name": "neuron fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. [GOC:dph]"}
{"concept_id": "C1658580", "aliases": [], "types": ["T043"], "canonical_name": "collateral sprouting in absence of injury", "definition": "The process in which outgrowths develop from the axons of intact undamaged neurons. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1658581", "aliases": ["down regulation of collateral sprouting", "down-regulation of collateral sprouting", "downregulation of collateral sprouting"], "types": ["T043"], "canonical_name": "negative regulation of collateral sprouting", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1658583", "aliases": ["downregulation of sprouting of injured axon", "down-regulation of sprouting of injured axon", "down regulation of sprouting of injured axon"], "types": ["T042"], "canonical_name": "negative regulation of sprouting of injured axon", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sprouting of an injured axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1658585", "aliases": ["regulation of release of sequestered calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "regulation of release of stored calcium ion (Ca2+)"}
{"concept_id": "C1658586", "aliases": ["positive regulation of release of stored calcium ion (Ca2+) into cytosol", "up regulation of release of sequestered calcium ion into cytosol", "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)", "up-regulation of release of sequestered calcium ion into cytosol", "upregulation of release of sequestered calcium ion into cytosol", "positive regulation of cytosolic release of stored calcium ion (Ca2+)"], "types": ["T043"], "canonical_name": "positive regulation of release of sequestered calcium ion into cytosol", "definition": "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai]"}
{"concept_id": "C1658587", "aliases": ["positive regulation of cytoplasmic release of stored calcium ion (Ca2+)", "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)", "positive regulation of release of sequestered calcium ion into cytoplasm"], "types": ["T043"], "canonical_name": "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm"}
{"concept_id": "C1658589", "aliases": ["3 Fe 4 S cluster binding", "iron-sulphur cluster 3Fe-4S binding", "triiron tetrasulfide cluster binding", "3 iron, 4 sulphur cluster binding", "triiron tetrasulphide cluster binding", "iron-sulfur cluster 3Fe-4S binding", "3Fe-4S cluster binding"], "types": ["T044"], "canonical_name": "3 iron, 4 sulfur cluster binding", "definition": "Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]"}
{"concept_id": "C1658591", "aliases": ["down-regulation of keratinocyte migration", "downregulation of keratinocyte migration", "down regulation of keratinocyte migration"], "types": ["T043"], "canonical_name": "negative regulation of keratinocyte migration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration. [GOC:ai]"}
{"concept_id": "C1658592", "aliases": [], "types": ["T044"], "canonical_name": "alpha-actinin 2 binding"}
{"concept_id": "C1658594", "aliases": ["calcium ion homeostasis in mitochondrion", "calcium ion homeostasis in mitochondria", "regulation of calcium ion concentration in mitochondrion", "regulation of calcium ion concentration in mitochondria", "regulation of mitochondrial calcium ion concentration", "mitochondrial calcium ion concentration regulation"], "types": ["T043"], "canonical_name": "mitochondrial calcium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. [GOC:ai, GOC:mah]"}
{"concept_id": "C1658595", "aliases": ["histone H3K4me", "histone lysine H3 K4 methylation", "histone H3 K4 methylation"], "types": ["T044"], "canonical_name": "histone H3-K4 methylation", "definition": "The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. [GOC:ai, GOC:pr]"}
{"concept_id": "C1658596", "aliases": ["actin gel biosynthesis", "actin gel formation"], "types": ["T043"], "canonical_name": "actin filament network formation", "definition": "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments. [GOC:ai]"}
{"concept_id": "C1658597", "aliases": ["minus end F-actin uncapping", "minus-end actin filament uncapping", "pointed end F-actin uncapping", "pointed-end F-actin uncapping", "minus-end F-actin uncapping", "pointed end actin filament uncapping", "minus end actin filament uncapping"], "types": ["T043"], "canonical_name": "pointed-end actin filament uncapping", "definition": "The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. [GOC:pf]"}
{"concept_id": "C1658609", "aliases": [], "types": ["T040"], "canonical_name": "multi-species biofilm formation", "definition": "A process in which planktonically growing microorganisms of different species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. [GOC:cc, GOC:di, GOC:tb]"}
{"concept_id": "C1658611", "aliases": ["recognition of host"], "types": ["T040"], "canonical_name": "detection of host", "definition": "The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1658612", "aliases": ["adhesion to other organism involved in symbiotic interaction", "host adhesion", "adhesion to host"], "types": ["T040"], "canonical_name": "adhesion of symbiont to host", "definition": "The attachment of a symbiont to its host via either adhesion molecules, general stickiness, or other mechanisms. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:bf, GOC:cc, GOC:dos, GOC:jl]"}
{"concept_id": "C1658613", "aliases": ["skeletal morphogenesis"], "types": ["T040"], "canonical_name": "skeletal system morphogenesis", "definition": "The process in which the anatomical structures of the skeleton are generated and organized. [GOC:dph, GOC:dsf, GOC:jid, GOC:tb]"}
{"concept_id": "C1658614", "aliases": ["embryonic skeletal development"], "types": ["T040"], "canonical_name": "embryonic skeletal system development", "definition": "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]"}
{"concept_id": "C1658615", "aliases": [], "types": ["T043"], "canonical_name": "regulation of astrocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of astrocyte differentiation. [GOC:vp, PMID:15139015]"}
{"concept_id": "C1658616", "aliases": ["upregulation of oligodendrocyte differentiation", "up-regulation of oligodendrocyte differentiation", "up regulation of oligodendrocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of oligodendrocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. [GOC:vp, PMID:15139015]"}
{"concept_id": "C1658617", "aliases": [], "types": ["T042"], "canonical_name": "epistomal sclerite development", "definition": "The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure. [GOC:rc]"}
{"concept_id": "C1658618", "aliases": ["skeletal myofiber development", "skeletal myofibre development", "skeletal muscle fibre development"], "types": ["T042"], "canonical_name": "skeletal muscle fiber development", "definition": "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle]"}
{"concept_id": "C1658619", "aliases": [], "types": ["T044"], "canonical_name": "2-phenyl-4H-1-benzopyran-4-one biosynthesis"}
{"concept_id": "C1658620", "aliases": ["flavonol metabolism"], "types": ["T044"], "canonical_name": "flavonol metabolic process", "definition": "The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities. [PMID:11402179]"}
{"concept_id": "C1658622", "aliases": ["elevation of calcium ion concentration in mitochondrion", "elevation of calcium ion concentration in mitochondria", "elevation of mitochondrial calcium ion concentration", "mitochondrial calcium ion concentration elevation"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial calcium ion concentration", "definition": "Any process that increases the concentration of calcium ions in mitochondria. [GOC:ai]"}
{"concept_id": "C1658623", "aliases": ["reduction of mitochondrial calcium ion concentration", "reduction of calcium ion concentration in mitochondrion", "reduction of calcium ion concentration in mitochondria", "mitochondrial calcium ion concentration reduction"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial calcium ion concentration", "definition": "Any process that decreases the concentration of calcium ions in mitochondria. [GOC:ai]"}
{"concept_id": "C1658624", "aliases": ["elevation of smooth ER calcium ion concentration", "elevation of calcium ion concentration in smooth endoplasmic reticulum", "elevation of smooth endoplasmic reticulum calcium ion concentration", "smooth endoplasmic reticulum calcium ion concentration elevation"], "types": ["T043"], "canonical_name": "positive regulation of smooth endoplasmic reticulum calcium ion concentration", "definition": "Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum. [GOC:ai]"}
{"concept_id": "C1658625", "aliases": [], "types": ["T044"], "canonical_name": "3RT activity"}
{"concept_id": "C1658626", "aliases": [], "types": ["T044"], "canonical_name": "small GTPase binding", "definition": "Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]"}
{"concept_id": "C1658627", "aliases": [], "types": ["T044"], "canonical_name": "kinetochore binding", "definition": "Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached. [GOC:jl]"}
{"concept_id": "C1658628", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myeloid cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of myeloid cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1658629", "aliases": [], "types": ["T040"], "canonical_name": "regulation of post-embryonic development", "definition": "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. [GOC:jid]"}
{"concept_id": "C1658753", "aliases": ["transferase inhibitor", "down regulation of transferase activity", "negative regulation of transferase activity", "down-regulation of transferase activity"], "types": ["T044"], "definition": "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. [GOC:ai]", "canonical_name": "downregulation of transferase activity"}
{"concept_id": "C1658769", "aliases": [], "types": ["T043"], "canonical_name": "R8 cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor. [PMID:11880339]"}
{"concept_id": "C1658770", "aliases": [], "types": ["T043"], "canonical_name": "R7 cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor. [PMID:11880339]"}
{"concept_id": "C1658772", "aliases": [], "types": ["T042"], "canonical_name": "compound eye corneal lens morphogenesis", "definition": "The process in which the anatomical structures of the compound eye corneal lens are generated and organized. [GOC:jid]"}
{"concept_id": "C1658773", "aliases": ["centrosome replication"], "types": ["T043"], "canonical_name": "centrosome duplication", "definition": "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. [GOC:ai]"}
{"concept_id": "C1658774", "aliases": [], "types": ["T043"], "canonical_name": "centrosome separation", "definition": "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. [GOC:ai]"}
{"concept_id": "C1658776", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H3-K4 methylation", "definition": "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. [GOC:ai]"}
{"concept_id": "C1658777", "aliases": ["5'-deoxyribose phosphate activity"], "types": ["T044"], "canonical_name": "5'-deoxyribose-5-phosphate lyase activity", "definition": "Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. [PMID:11251121, PMID:16120966]"}
{"concept_id": "C1658778", "aliases": [], "types": ["T044"], "canonical_name": "dRP lyase activity"}
{"concept_id": "C1658779", "aliases": ["regulation of neurotransmitter import", "regulation of neurotransmitter reuptake"], "types": ["T043"], "canonical_name": "regulation of neurotransmitter uptake", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C1658780", "aliases": ["down-regulation of monopolar cell growth", "downregulation of monopolar cell growth", "down regulation of monopolar cell growth"], "types": ["T043"], "canonical_name": "negative regulation of monopolar cell growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. [GOC:ai]"}
{"concept_id": "C1658783", "aliases": [], "types": ["T040"], "canonical_name": "response to electrical stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. [GOC:ai]"}
{"concept_id": "C1658784", "aliases": [], "types": ["T044"], "canonical_name": "peptidolysis during protein maturation"}
{"concept_id": "C1658785", "aliases": ["epinephrine import", "adrenaline reuptake", "epinephrine reuptake", "adrenaline uptake"], "types": ["T043"], "canonical_name": "epinephrine uptake", "definition": "The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:ai]"}
{"concept_id": "C1658786", "aliases": ["actin cortical patch localisation", "establishment and maintenance of actin cortical patch localization"], "types": ["T043"], "canonical_name": "actin cortical patch localization", "definition": "Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells. [GOC:mah]"}
{"concept_id": "C1658787", "aliases": ["maintenance of ER localization", "maintenance of endoplasmic reticulum localization"], "types": ["T043"], "canonical_name": "maintenance of ER location", "definition": "Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1658789", "aliases": [], "types": ["T042"], "canonical_name": "posterior cibarial plate morphogenesis", "definition": "The process in which the anatomical structures of the posterior cibarial plate are generated and organized. [GOC:rc]"}
{"concept_id": "C1658933", "aliases": ["signal transduction involved in meiotic recombination checkpoint", "pachytene checkpoint", "meiotic recombination checkpoint"], "types": ["T043"], "canonical_name": "meiotic recombination checkpoint signaling", "definition": "A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes. [PMID:14718568]"}
{"concept_id": "C1658934", "aliases": ["regulation of endocytosis by exocyst localisation", "relocation of endocytosis", "regulation of site selection of endocytosis", "spatial regulation of endocytosis"], "types": ["T043"], "canonical_name": "regulation of endocytosis by exocyst localization", "definition": "Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1658935", "aliases": ["proteolysis during cellular protein catabolic process", "proteolysis involved in cellular protein catabolic process", "peptidolysis during cellular protein catabolism", "peptidolysis involved in cellular protein catabolic process", "proteolysis during cellular protein catabolism", "peptidolysis involved in cellular protein catabolism", "peptidolysis during cellular protein catabolic process"], "types": ["T044"], "canonical_name": "proteolysis involved in protein catabolic process", "definition": "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1658936", "aliases": ["inhibition of neurotransmitter import"], "types": ["T043"], "canonical_name": "inhibition of neurotransmitter uptake", "definition": "Any process that prevents the activation of the directed movement of a neurotransmitter into a cell. [GOC:ai]"}
{"concept_id": "C1658937", "aliases": ["regulation of serotonin import", "regulation of 5-HT uptake", "regulation of 5-hydroxytryptamine uptake", "regulation of 5HT uptake"], "types": ["T043"], "canonical_name": "regulation of serotonin uptake", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell. [GOC:ai]"}
{"concept_id": "C1658938", "aliases": ["histamine import"], "types": ["T043"], "canonical_name": "histamine uptake", "definition": "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]"}
{"concept_id": "C1658939", "aliases": ["quaternary-ammonium-compound ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type quaternary ammonium compound transporting activity", "definition": "Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H(+) + phosphate + quaternary ammonium(in). [GOC:pz, RHEA:11036]"}
{"concept_id": "C1658941", "aliases": ["up regulation of mating type switching", "upregulation of mating type switching", "up-regulation of mating type switching"], "types": ["T043"], "canonical_name": "positive regulation of mating type switching", "definition": "Any process that activates or increases the frequency, rate or extent of mating type switching. [GOC:mah]"}
{"concept_id": "C1658943", "aliases": ["thermoception, sensory transduction of temperature stimulus", "sensory transduction of thermal stimulus during thermoception", "thermoception, sensory detection of temperature stimulus", "sensory detection of thermal stimulus during thermoception", "sensory detection of temperature stimulus during thermoception", "thermoception, sensory detection of thermal stimulus", "thermoception, sensory transduction of thermal stimulus", "sensory transduction of temperature stimulus during thermoception"], "types": ["T040"], "canonical_name": "detection of temperature stimulus involved in thermoception", "definition": "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception. [GOC:ai, GOC:dos]"}
{"concept_id": "C1658944", "aliases": ["interphase of meiotic cell cycle"], "types": ["T079"], "canonical_name": "meiotic interphase", "definition": "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1658945", "aliases": ["downregulation of neurotransmitter transport", "down-regulation of neurotransmitter transport", "down regulation of neurotransmitter transport"], "types": ["T043"], "canonical_name": "negative regulation of neurotransmitter transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1658946", "aliases": [], "types": ["T039"], "canonical_name": "response to biomechanical stress"}
{"concept_id": "C1658947", "aliases": ["establishment and maintenance of spindle localization", "spindle localisation"], "types": ["T038"], "canonical_name": "spindle localization", "definition": "Any process in which is the spindle is transported to, and/or maintained in, a specific location. [GOC:ai]"}
{"concept_id": "C1658965", "aliases": ["hydrolase activator", "up-regulation of hydrolase activity", "upregulation of hydrolase activity", "up regulation of hydrolase activity"], "types": ["T044"], "canonical_name": "positive regulation of hydrolase activity", "definition": "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. [GOC:ai]"}
{"concept_id": "C1658966", "aliases": ["up regulation of oxidoreductase activity", "upregulation of oxidoreductase activity", "up-regulation of oxidoreductase activity", "oxidoreductase activator"], "types": ["T044"], "canonical_name": "positive regulation of oxidoreductase activity", "definition": "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. [GOC:ai]"}
{"concept_id": "C1658968", "aliases": ["positive regulation of histamine import", "up-regulation of histamine uptake", "up regulation of histamine uptake", "upregulation of histamine uptake"], "types": ["T043"], "canonical_name": "positive regulation of histamine uptake", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell. [GOC:ai]"}
{"concept_id": "C1658969", "aliases": ["negative regulation of levarterenol uptake", "down regulation of norepinephrine uptake", "negative regulation of noradrenaline uptake", "downregulation of norepinephrine uptake", "negative regulation of norepinephrine import", "down-regulation of norepinephrine uptake"], "types": ["T043"], "canonical_name": "negative regulation of norepinephrine uptake", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. [GOC:ai]"}
{"concept_id": "C1658970", "aliases": ["up regulation of norepinephrine uptake", "positive regulation of noradrenaline uptake", "upregulation of norepinephrine uptake", "positive regulation of levarterenol uptake", "up-regulation of norepinephrine uptake", "positive regulation of norepinephrine import"], "types": ["T043"], "canonical_name": "positive regulation of norepinephrine uptake", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. [GOC:ai]"}
{"concept_id": "C1658971", "aliases": ["regulation of adrenaline uptake", "regulation of epinephrine import"], "types": ["T043"], "canonical_name": "regulation of epinephrine uptake", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell. [GOC:ai]"}
{"concept_id": "C1658973", "aliases": ["phytase activity"], "types": ["T044"], "canonical_name": "phytase activity"}
{"concept_id": "C1658974", "aliases": ["mitochondrial signalling pathway", "retrograde response", "mitochondrial signaling pathway", "mitochondria-nucleus signal transduction"], "types": ["T043"], "canonical_name": "mitochondria-nucleus signaling pathway", "definition": "The series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function. [GOC:jh, PMID:15068799]"}
{"concept_id": "C1658975", "aliases": [], "types": ["T042"], "canonical_name": "wing and notum subfield formation", "definition": "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures. [PMID:10860999]"}
{"concept_id": "C1658978", "aliases": [], "types": ["T042"], "canonical_name": "formation of growth cone in injured axon", "definition": "The formation of a growth cone in an injured axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1658979", "aliases": ["localization to membrane", "establishment and maintenance of position in membrane", "establishment and maintenance of localization in membrane", "localisation within membrane"], "types": ["T043"], "canonical_name": "localization within membrane", "definition": "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. [GOC:ai]"}
{"concept_id": "C1658980", "aliases": ["ATP-dependent RNA 5'-hydroxyl-kinase activity", "ATP-dependent RNA kinase activity", "ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity", "ATP-dependent polyribonucleotide kinase activity"], "types": ["T044"], "canonical_name": "polyribonucleotide 5'-hydroxyl-kinase activity", "definition": "Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA. [EC:2.7.1.78]"}
{"concept_id": "C1658981", "aliases": [], "types": ["T044"], "canonical_name": "ent-7-alpha-hydroxykaurenoate oxidase activity", "definition": "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). [EC:1.14.13.79, MetaCyc:RXN1F-160]"}
{"concept_id": "C1659083", "aliases": ["regulation of pigmentation during development"], "types": ["T040"], "canonical_name": "regulation of developmental pigmentation", "definition": "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. [GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1659084", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine decanoylation", "definition": "The decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin. [GOC:jsg, PMID:11546772, RESID:AA0387]"}
{"concept_id": "C1659085", "aliases": [], "types": ["T044"], "canonical_name": "muscle alpha-actinin binding", "definition": "Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. [PMID:10984498, PMID:11699871, PMID:15014165]"}
{"concept_id": "C1659086", "aliases": ["establishment and maintenance of plastid localization", "plastid localisation"], "types": ["T038"], "canonical_name": "plastid localization", "definition": "Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]"}
{"concept_id": "C1659087", "aliases": ["cell nucleus localization", "establishment and maintenance of nucleus localization", "nucleus localisation", "localization of nucleus"], "types": ["T038"], "canonical_name": "nucleus localization", "definition": "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]"}
{"concept_id": "C1659088", "aliases": [], "types": ["T044"], "canonical_name": "syncytial blastoderm cell cycle regulator"}
{"concept_id": "C1659089", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1,3-galactosyltransferase activity", "definition": "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage. [GOC:hjd, PMID:10854427]"}
{"concept_id": "C1659090", "aliases": ["calponin homology domain binding"], "types": ["T044"], "canonical_name": "CH domain binding", "definition": "Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins. [PMID:11911887, Prosite:PDOC50021]"}
{"concept_id": "C1659103", "aliases": [], "types": ["T044"], "canonical_name": "electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity", "definition": "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II. [GOC:ai, ISBN:0716731363]"}
{"concept_id": "C1659105", "aliases": [], "types": ["T045"], "canonical_name": "tRNA acetylation", "definition": "The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]"}
{"concept_id": "C1659109", "aliases": ["centrosome positioning", "establishment of centrosome localisation"], "types": ["T043"], "canonical_name": "establishment of centrosome localization", "definition": "The directed movement of the centrosome to a specific location. [GOC:ai]"}
{"concept_id": "C1659110", "aliases": ["establishment and maintenance of nuclear pore localization", "nuclear pore localisation"], "types": ["T043"], "canonical_name": "nuclear pore localization", "definition": "Any process in which nuclear pores are transported to, or maintained in, a specific location. [GOC:ai]"}
{"concept_id": "C1659111", "aliases": ["exoinulinase activity", "inulase activity", "2,1-beta-D-fructan fructanohydrolase activity", "endo-inulinase activity", "indoinulinase activity"], "types": ["T044"], "canonical_name": "inulinase activity", "definition": "Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin. [EC:3.2.1.7]"}
{"concept_id": "C1659113", "aliases": ["inductive cell-cell signalling"], "types": ["T043"], "canonical_name": "inductive cell-cell signaling", "definition": "Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate. [GOC:mah]"}
{"concept_id": "C1659114", "aliases": ["intrinsic to plasma membrane"], "types": ["T026"], "canonical_name": "intrinsic component of plasma membrane", "definition": "The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1659116", "aliases": ["up regulation of protein modification", "up-regulation of protein modification", "upregulation of protein modification"], "types": ["T044"], "canonical_name": "positive regulation of protein modification process", "definition": "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. [GOC:mah, GOC:tb]"}
{"concept_id": "C1659117", "aliases": [], "types": ["T043"], "canonical_name": "response to nutrient levels", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah]"}
{"concept_id": "C1659118", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1A adrenergic receptor ligand"}
{"concept_id": "C1659119", "aliases": [], "types": ["T042"], "canonical_name": "bone marrow development", "definition": "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1659121", "aliases": [], "types": ["T045"], "canonical_name": "Myf5 binding"}
{"concept_id": "C1659137", "aliases": [], "types": ["T044"], "canonical_name": "glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out). [GOC:ai]"}
{"concept_id": "C1659138", "aliases": ["isopanose metabolism", "6-alpha-maltosylglucose metabolism", "isopanose metabolic process"], "types": ["T043"], "canonical_name": "6-alpha-maltosylglucose metabolic process", "definition": "The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose. [GOC:ai, LIGAND:C03367, PubChem_Compound:439991]"}
{"concept_id": "C1659140", "aliases": ["establishment of Golgi localisation", "establishment of Golgi body localization", "establishment of Golgi apparatus localization"], "types": ["T043"], "canonical_name": "establishment of Golgi localization", "definition": "The directed movement of the Golgi to a specific location. [GOC:ai]"}
{"concept_id": "C1659141", "aliases": ["F-actin uncapping"], "types": ["T043"], "canonical_name": "actin filament uncapping", "definition": "The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. [GOC:pf]"}
{"concept_id": "C1659142", "aliases": [], "types": ["T044"], "canonical_name": "far-red light photoreceptor activity", "definition": "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation. [GOC:nln]"}
{"concept_id": "C1659143", "aliases": [], "types": ["T043"], "canonical_name": "regulation of axial mesodermal cell fate determination", "definition": "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1659144", "aliases": ["upregulation of axial mesodermal cell fate specification", "up regulation of axial mesodermal cell fate specification", "up-regulation of axial mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "positive regulation of axial mesodermal cell fate specification", "definition": "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1659145", "aliases": ["down-regulation of exogen", "down regulation of exogen", "downregulation of exogen"], "types": ["T040"], "canonical_name": "negative regulation of exogen"}
{"concept_id": "C1659156", "aliases": ["cell-cell junction organisation", "cell-cell junction assembly and maintenance", "intercellular junction assembly and maintenance"], "types": ["T043"], "canonical_name": "cell-cell junction organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1659157", "aliases": ["downregulation of proteolysis", "negative regulation of peptidolysis", "down-regulation of proteolysis", "down regulation of proteolysis"], "types": ["T044"], "canonical_name": "negative regulation of proteolysis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:go_curators]"}
{"concept_id": "C1659158", "aliases": ["positive regulation of peptidolysis", "upregulation of proteolysis", "up-regulation of proteolysis", "up regulation of proteolysis"], "types": ["T044"], "canonical_name": "positive regulation of proteolysis", "definition": "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:go_curators]"}
{"concept_id": "C1659159", "aliases": ["up-regulation of endo-1,4-beta-xylanase activity", "upregulation of endo-1,4-beta-xylanase activity", "up regulation of endo-1,4-beta-xylanase activity"], "types": ["T044"], "canonical_name": "positive regulation of endo-1,4-beta-xylanase activity", "definition": "Any process that activates or increases the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. [EC:3.2.1.8, GOC:ai]"}
{"concept_id": "C1659164", "aliases": ["negative regulation of killing of cells of other organism", "down regulation of killing of cells of another organism", "down-regulation of killing of cells of another organism", "downregulation of killing of cells of another organism"], "types": ["T043"], "canonical_name": "negative regulation of killing of cells of another organism", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism. [GOC:ai]"}
{"concept_id": "C1659165", "aliases": ["cytolysis of cells of another organism", "cytolysis in other organism"], "types": ["T043"], "canonical_name": "cytolysis in another organism", "definition": "The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm. [GOC:ai]"}
{"concept_id": "C1659166", "aliases": [], "types": ["T045"], "canonical_name": "DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA). [EC:2.1.1.37, PMID:15689527]"}
{"concept_id": "C1659167", "aliases": [], "types": ["T045"], "canonical_name": "DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN. [EC:2.1.1.37, PMID:15689527]"}
{"concept_id": "C1659168", "aliases": [], "types": ["T045"], "canonical_name": "DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG. [EC:2.1.1.37, PMID:15689527]"}
{"concept_id": "C1659169", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase methylesterase activity"}
{"concept_id": "C1659172", "aliases": [], "types": ["T042"], "canonical_name": "clypeus development", "definition": "The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head. [GOC:rc]"}
{"concept_id": "C1659173", "aliases": ["protein amino acid S-linked glycosylation"], "types": ["T044"], "canonical_name": "protein S-linked glycosylation", "definition": "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine. [GOC:ai, GOC:jsg, GOC:pr]"}
{"concept_id": "C1659174", "aliases": ["intrinsic to cell outer membrane"], "types": ["T026"], "canonical_name": "intrinsic component of cell outer membrane", "definition": "The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1659182", "aliases": ["down regulation of mesodermal cell fate determination", "downregulation of mesodermal cell fate determination", "down-regulation of mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "negative regulation of mesodermal cell fate determination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1659183", "aliases": [], "types": ["T043"], "canonical_name": "paraxial mesodermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell. [GOC:dgh]"}
{"concept_id": "C1659184", "aliases": ["up-regulation of paraxial mesodermal cell fate determination", "upregulation of paraxial mesodermal cell fate determination", "up regulation of paraxial mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "positive regulation of paraxial mesodermal cell fate determination", "definition": "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1659185", "aliases": [], "types": ["T042"], "canonical_name": "regulation of paraxial mesodermal cell fate specification", "definition": "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1659186", "aliases": ["down-regulation of paraxial mesodermal cell fate specification", "downregulation of paraxial mesodermal cell fate specification", "down regulation of paraxial mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of paraxial mesodermal cell fate specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1659195", "aliases": [], "types": ["T038"], "canonical_name": "response to viral dsRNA"}
{"concept_id": "C1659196", "aliases": ["alkane metabolism"], "types": ["T043"], "canonical_name": "cellular alkane metabolic process", "definition": "The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells. [GOC:jl, Wikipedia:Alkane]"}
{"concept_id": "C1659197", "aliases": [], "types": ["T043"], "canonical_name": "endosome to pigment granule transport", "definition": "The directed movement of substances from endosomes to pigment granules. [GOC:jl]"}
{"concept_id": "C1659198", "aliases": [], "types": ["T026"], "canonical_name": "cytoproct", "definition": "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium. [PMID:10503189, PMID:23317460, PMID:27889663]"}
{"concept_id": "C1659199", "aliases": [], "types": ["T044"], "canonical_name": "regulation of fatty acid beta-oxidation", "definition": "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. [GOC:mah]"}
{"concept_id": "C1659200", "aliases": [], "types": ["T043"], "canonical_name": "pyridoxal phosphate transport", "definition": "The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6. [GOC:mah]"}
{"concept_id": "C1659432", "aliases": ["upregulation of transferase activity", "transferase activator", "up regulation of transferase activity", "up-regulation of transferase activity"], "types": ["T044"], "canonical_name": "positive regulation of transferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. [GOC:ai]"}
{"concept_id": "C1659433", "aliases": [], "types": ["T040"], "canonical_name": "equilibrioception by visual perception"}
{"concept_id": "C1659436", "aliases": ["levarterenol uptake", "norepinephrine reuptake", "noradrenaline uptake", "norepinephrine import", "levarterenol reuptake", "noradrenaline reuptake"], "types": ["T043"], "canonical_name": "norepinephrine uptake", "definition": "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. [GOC:ai]"}
{"concept_id": "C1659437", "aliases": ["inhibition of adrenaline uptake", "inhibition of epinephrine import"], "types": ["T043"], "canonical_name": "inhibition of epinephrine uptake", "definition": "Any process that prevents the activation of the directed movement of epinephrine into a cell. [GOC:ai]"}
{"concept_id": "C1659438", "aliases": ["regulation of acetylcholine import"], "types": ["T043"], "canonical_name": "regulation of acetylcholine uptake", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell. [GOC:ai]"}
{"concept_id": "C1659439", "aliases": ["down-regulation of acetylcholine uptake", "negative regulation of acetylcholine import", "downregulation of acetylcholine uptake", "down regulation of acetylcholine uptake"], "types": ["T043"], "canonical_name": "negative regulation of acetylcholine uptake", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell. [GOC:ai]"}
{"concept_id": "C1659440", "aliases": ["inhibition of acetylcholine import"], "types": ["T043"], "canonical_name": "inhibition of acetylcholine uptake", "definition": "Any process that prevents the activation of the directed movement of acetylcholine into a cell. [GOC:ai]"}
{"concept_id": "C1659442", "aliases": ["up regulation of cytolysis of cells of another organism", "upregulation of cytolysis of cells of another organism", "positive regulation of cytolysis of cells of another organism", "up-regulation of cytolysis of cells of another organism", "positive regulation of cytolysis in other organism"], "types": ["T043"], "canonical_name": "positive regulation of cytolysis in another organism", "definition": "Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism. [GOC:ai]"}
{"concept_id": "C1659443", "aliases": ["conversion to meiosis", "entry into meiosis", "initiation of meiosis"], "types": ["T043"], "canonical_name": "meiotic entry"}
{"concept_id": "C1659455", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme Q6 binding"}
{"concept_id": "C1659456", "aliases": [], "types": ["T042"], "canonical_name": "R2/R5 cell differentiation", "definition": "The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster. [GOC:jid]"}
{"concept_id": "C1659457", "aliases": ["pigmentation during development"], "types": ["T040"], "canonical_name": "developmental pigmentation", "definition": "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. [ISBN:0582227089]"}
{"concept_id": "C1659459", "aliases": [], "types": ["T044"], "canonical_name": "histamine binding", "definition": "Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]"}
{"concept_id": "C1659460", "aliases": ["response to mineralocorticoid stimulus"], "types": ["T043"], "canonical_name": "response to mineralocorticoid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. [GOC:ai, PMID:9884123]"}
{"concept_id": "C1659461", "aliases": ["endoplasmic reticulum localisation", "establishment and maintenance of ER localization", "ER localization"], "types": ["T038"], "canonical_name": "endoplasmic reticulum localization", "definition": "Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]"}
{"concept_id": "C1659462", "aliases": ["establishment of intracellular localization", "establishment of localization within cell"], "types": ["T043"], "canonical_name": "positioning within cell"}
{"concept_id": "C1659463", "aliases": [], "types": ["T043"], "canonical_name": "cellular sequestering"}
{"concept_id": "C1659464", "aliases": [], "types": ["T043"], "canonical_name": "cellular storage"}
{"concept_id": "C1659465", "aliases": ["intracellular retention"], "types": ["T043"], "canonical_name": "retention within cell"}
{"concept_id": "C1659466", "aliases": ["intracellular storage"], "types": ["T043"], "canonical_name": "storage within cell"}
{"concept_id": "C1659467", "aliases": ["maintenance of intracellular localization"], "types": ["T043"], "canonical_name": "maintenance of localization within cell"}
{"concept_id": "C1659468", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of chromosome localization"}
{"concept_id": "C1659469", "aliases": ["auxin conjugate metabolism"], "types": ["T044"], "canonical_name": "auxin conjugate metabolic process", "definition": "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin. [GOC:sm]"}
{"concept_id": "C1659470", "aliases": ["cadmium ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type cadmium transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole). [PMID:12455987]"}
{"concept_id": "C1659471", "aliases": ["corticoliberin binding", "CRF binding", "CRH binding", "corticotropin-releasing factor binding"], "types": ["T044"], "canonical_name": "corticotropin-releasing hormone binding", "definition": "Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. [PMID:7556876]"}
{"concept_id": "C1659474", "aliases": [], "types": ["T044"], "canonical_name": "tetraterpene biosynthesis"}
{"concept_id": "C1659548", "aliases": ["downregulation of myeloid cell differentiation", "down regulation of myeloid cell differentiation", "down-regulation of myeloid cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of myeloid cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1659549", "aliases": ["upregulation of myeloid cell differentiation", "up regulation of myeloid cell differentiation", "up-regulation of myeloid cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of myeloid cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. [GOC:go_curators]"}
{"concept_id": "C1659551", "aliases": ["positive regulation of nerve growth factor receptor signaling pathway", "up-regulation of nerve growth factor receptor signaling pathway", "positive regulation of NGF receptor signalling pathway", "positive regulation of NGF receptor signaling pathway", "positive regulation of nerve growth factor receptor signalling pathway", "up regulation of nerve growth factor receptor signaling pathway", "upregulation of nerve growth factor receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of neurotrophin TRK receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. [GOC:ai]"}
{"concept_id": "C1659554", "aliases": ["maintenance of mitochondrion localization", "maintenance of mitochondria localization"], "types": ["T043"], "canonical_name": "maintenance of mitochondrion location", "definition": "Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1659555", "aliases": ["establishment of plastid localisation"], "types": ["T043"], "canonical_name": "establishment of plastid localization", "definition": "The directed movement of a plastid to a specific location in the cell. [GOC:ai]"}
{"concept_id": "C1659558", "aliases": ["signal transduction involved in intra-S DNA damage checkpoint", "intra-S DNA damage checkpoint", "mitotic intra-S DNA damage checkpoint"], "types": ["T043"], "canonical_name": "mitotic intra-S DNA damage checkpoint signaling", "definition": "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. [GOC:vw]"}
{"concept_id": "C1659559", "aliases": [], "types": ["T026"], "canonical_name": "nuclear proteasome regulatory particle", "definition": "The regulatory subcomplex of a proteasome located in the nucleus of a cell. [GOC:mah]"}
{"concept_id": "C1659572", "aliases": [], "types": ["T040"], "canonical_name": "nitric oxide (NO) detoxification"}
{"concept_id": "C1659573", "aliases": ["response to corticosterone stimulus"], "types": ["T043"], "canonical_name": "response to corticosterone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. [PMID:15240347]"}
{"concept_id": "C1659576", "aliases": [], "types": ["T044"], "canonical_name": "regulation of endo-1,4-beta-xylanase activity", "definition": "Any process that modulates the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. [EC:3.2.1.8, GOC:ai]"}
{"concept_id": "C1659577", "aliases": ["pullulan metabolism"], "types": ["T044"], "canonical_name": "pullulan metabolic process", "definition": "The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. [PMID:15013381]"}
{"concept_id": "C1659578", "aliases": ["cellular oligosaccharide degradation", "cellular oligosaccharide catabolism", "cellular oligosaccharide breakdown"], "types": ["T044"], "canonical_name": "cellular oligosaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells. [GOC:ai]"}
{"concept_id": "C1659579", "aliases": [], "types": ["T042"], "canonical_name": "R3/R4 cell differentiation", "definition": "The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster. [GOC:jid]"}
{"concept_id": "C1659580", "aliases": ["up-regulation of mesodermal cell fate determination", "up regulation of mesodermal cell fate determination", "upregulation of mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "positive regulation of mesodermal cell fate determination", "definition": "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1659583", "aliases": [], "types": ["T045"], "canonical_name": "chloroplast mRNA processing", "definition": "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs. [GOC:tb, PMID:9648738]"}
{"concept_id": "C1659584", "aliases": [], "types": ["T044"], "canonical_name": "globin binding"}
{"concept_id": "C1659594", "aliases": ["positive regulation of progression through cell cycle", "upregulation of progression through cell cycle", "up regulation of progression through cell cycle", "positive regulation of cell cycle progression", "up-regulation of progression through cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of cell cycle", "definition": "Any process that activates or increases the rate or extent of progression through the cell cycle. [GOC:go_curators]"}
{"concept_id": "C1659596", "aliases": ["ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "ATP-dependent DNA 5'-hydroxyl-kinase activity", "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity", "ATP-dependent DNA kinase activity"], "types": ["T044"], "canonical_name": "polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "definition": "Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. [RHEA:15669]"}
{"concept_id": "C1659597", "aliases": ["ATP:5'-dephosphopolynucleotide 5'-phosphatase activity", "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity", "polynucleotide kinase activity", "ATP-dependent polynucleotide kinase activity", "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity"], "types": ["T044"], "canonical_name": "polynucleotide kinase activity", "definition": "Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. [RHEA:54580]"}
{"concept_id": "C1659598", "aliases": ["down regulation of endo-1,4-beta-xylanase activity", "down-regulation of endo-1,4-beta-xylanase activity", "downregulation of endo-1,4-beta-xylanase activity"], "types": ["T044"], "canonical_name": "negative regulation of endo-1,4-beta-xylanase activity", "definition": "Any process that stops or reduces the rate of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. [EC:3.2.1.8, GOC:ai]"}
{"concept_id": "C1659599", "aliases": ["endo-1,4-beta-xylanase activator"], "types": ["T044"], "canonical_name": "xylanase activator"}
{"concept_id": "C1659600", "aliases": [], "types": ["T044"], "canonical_name": "BH3 domain binding", "definition": "Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259]"}
{"concept_id": "C1659604", "aliases": [], "types": ["T044"], "canonical_name": "SAX activity"}
{"concept_id": "C1659605", "aliases": ["interaction with host"], "types": ["T043"], "canonical_name": "biological process involved in interaction with host", "definition": "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. [GOC:cc]"}
{"concept_id": "C1659606", "aliases": [], "types": ["T043"], "canonical_name": "intracellular protein transport in other organism during symbiotic interaction"}
{"concept_id": "C1659608", "aliases": [], "types": ["T039"], "canonical_name": "cellular response to stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. [GOC:bf, GOC:jl]"}
{"concept_id": "C1659609", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 2A binding", "definition": "Binding to protein phosphatase 2A. [GOC:ai]"}
{"concept_id": "C1659610", "aliases": [], "types": ["T026"], "canonical_name": "vesicle lumen", "definition": "The volume enclosed by the membrane or protein that forms a vesicle. [GOC:mah, GOC:vesicles]"}
{"concept_id": "C1659612", "aliases": ["down-regulation of developmental growth", "down regulation of developmental growth", "downregulation of developmental growth"], "types": ["T040"], "canonical_name": "negative regulation of developmental growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. [GOC:go_curators]"}
{"concept_id": "C1659613", "aliases": [], "types": ["T042"], "canonical_name": "collateral sprouting of injured axon", "definition": "The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process in which outgrowths develop from the shafts of existing axons. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1659614", "aliases": ["up regulation of axon regeneration", "upregulation of axon regeneration", "up-regulation of axon regeneration"], "types": ["T042"], "canonical_name": "positive regulation of axon regeneration", "definition": "Any process that activates, maintains or increases the rate of axon regeneration. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1659615", "aliases": [], "types": ["T042"], "canonical_name": "regulation of sprouting of injured axon", "definition": "Any process that modulates the frequency, rate or extent of sprouting of an injured axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1659753", "aliases": [], "types": ["T042"], "canonical_name": "regulation of mesodermal cell fate determination", "definition": "Any process that modulates the frequency, rate or extent of mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1659754", "aliases": [], "types": ["T042"], "canonical_name": "paraxial mesodermal cell fate commitment", "definition": "The process in which a cell becomes committed to become a paraxial mesoderm cell. [GOC:dgh]"}
{"concept_id": "C1659755", "aliases": [], "types": ["T042"], "canonical_name": "paraxial mesodermal cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:dgh]"}
{"concept_id": "C1659756", "aliases": ["sensory perception, sensory transduction of thermal stimulus", "sensory detection of thermal stimulus during sensory perception", "sensory detection of temperature stimulus during sensory perception", "sensory perception, sensory detection of thermal stimulus", "sensory transduction of thermal stimulus during sensory perception", "sensory perception, sensory transduction of temperature stimulus", "sensory detection of temperature stimulus", "sensory transduction of temperature stimulus during sensory perception", "sensory transduction of temperature stimulus", "sensory perception, sensory detection of temperature stimulus"], "types": ["T038"], "canonical_name": "detection of temperature stimulus involved in sensory perception", "definition": "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. [GOC:ai, GOC:dos]"}
{"concept_id": "C1659757", "aliases": [], "types": ["T026"], "canonical_name": "APC regulator"}
{"concept_id": "C1659766", "aliases": ["GTP-dependent polyribonucleotide kinase activity", "GTP-dependent RNA 5'-hydroxyl-kinase activity", "GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity", "GTP-dependent RNA kinase activity"], "types": ["T044"], "canonical_name": "GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "definition": "Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA. [EC:2.7.1.78, PMID:8428918]"}
{"concept_id": "C1659767", "aliases": [], "types": ["T026"], "canonical_name": "mitochondrial envelope", "definition": "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. [GOC:ai, GOC:pz]"}
{"concept_id": "C1659771", "aliases": ["downregulation of protein amino acid autophosphorylation", "down-regulation of protein amino acid autophosphorylation", "negative regulation of protein amino acid autophosphorylation", "down regulation of protein amino acid autophosphorylation"], "types": ["T044"], "canonical_name": "negative regulation of protein autophosphorylation", "definition": "Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. [GOC:mah]"}
{"concept_id": "C1659997", "aliases": [], "types": ["T043"], "canonical_name": "attachment of spindle microtubules to kinetochore during meiotic chromosome segregation"}
{"concept_id": "C1659999", "aliases": ["transferase regulator"], "types": ["T044"], "canonical_name": "regulation of transferase activity", "definition": "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. [GOC:ai]"}
{"concept_id": "C1660000", "aliases": ["oxidoreductase regulator"], "types": ["T044"], "canonical_name": "regulation of oxidoreductase activity", "definition": "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:ai]"}
{"concept_id": "C1660001", "aliases": ["regulation of cyclic nucleotide phosphodiesterase activity", "regulation of 3',5' cyclic nucleotide phosphodiesterase activity", "3',5' cyclic nucleotide phosphodiesterase regulator"], "types": ["T044"], "canonical_name": "regulation of cyclic-nucleotide phosphodiesterase activity", "definition": "Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. [EC:3.1.4.17, GOC:ai, GOC:tb]"}
{"concept_id": "C1660003", "aliases": [], "types": ["T043"], "canonical_name": "protein maturation", "definition": "Any process leading to the attainment of the full functional capacity of a protein. [GOC:ai]"}
{"concept_id": "C1660004", "aliases": ["downregulation of histamine uptake", "negative regulation of histamine import", "down regulation of histamine uptake", "down-regulation of histamine uptake"], "types": ["T043"], "canonical_name": "negative regulation of histamine uptake", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell. [GOC:ai]"}
{"concept_id": "C1660005", "aliases": ["cytosolic proteasome core complex, alpha-subunit complex location"], "types": ["T026"], "canonical_name": "cytosolic proteasome core complex, alpha-subunit complex", "definition": "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex. [GOC:mah, GOC:mtg_sensu]"}
{"concept_id": "C1660007", "aliases": [], "types": ["T045"], "canonical_name": "MyoD binding"}
{"concept_id": "C1660008", "aliases": ["establishment and maintenance of Golgi localization", "Golgi body localization", "Golgi localisation", "Golgi apparatus localization"], "types": ["T043"], "canonical_name": "Golgi localization", "definition": "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]"}
{"concept_id": "C1660142", "aliases": ["perception of orientation with respect to gravity by proprioception", "equilibrioception by proprioception"], "types": ["T041"], "canonical_name": "proprioception involved in equilibrioception", "definition": "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity. [GOC:ai]"}
{"concept_id": "C1660145", "aliases": ["inhibition of histamine import"], "types": ["T043"], "canonical_name": "inhibition of histamine uptake", "definition": "Any process that prevents the activation of the directed movement of histamine into a cell. [GOC:ai]"}
{"concept_id": "C1660146", "aliases": ["acetylcholine import"], "types": ["T043"], "canonical_name": "acetylcholine uptake", "definition": "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. [GOC:ai]"}
{"concept_id": "C1660148", "aliases": [], "types": ["T044"], "canonical_name": "tetraterpene catabolism"}
{"concept_id": "C1660150", "aliases": [], "types": ["T026"], "canonical_name": "bridging actin filaments"}
{"concept_id": "C1660152", "aliases": [], "types": ["T040"], "canonical_name": "developmental growth", "definition": "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. [GOC:go_curators]"}
{"concept_id": "C1660153", "aliases": ["cell localization", "establishment and maintenance of cell localization", "establishment and maintenance of localization of cell", "localisation of cell"], "types": ["T038"], "canonical_name": "localization of cell", "definition": "Any process in which a cell is transported to, and/or maintained in, a specific location. [GOC:ai]"}
{"concept_id": "C1660154", "aliases": ["NAD transporter activity", "nicotinamide adenine dinucleotide transmembrane transporter activity", "oxidized nicotinamide adenine dinucleotide transmembrane transporter activity", "oxidized NAD transporter activity", "reduced NAD transporter activity", "NAD+ transporter activity", "NADH transporter activity", "NAD (reduced) transporter activity", "NAD (oxidized) transporter activity", "reduced nicotinamide adenine dinucleotide transmembrane transporter activity"], "types": ["T044"], "canonical_name": "NAD transmembrane transporter activity", "definition": "Enables the transfer of NAD from one side of a membrane to the other. [GOC:TermGenie]"}
{"concept_id": "C1660155", "aliases": ["germline initiation of meiosis", "germline conversion to meiosis", "germline entry into meiosis"], "types": ["T043"], "canonical_name": "germline meiotic entry"}
{"concept_id": "C1660165", "aliases": ["protein amino acid decanoylation"], "types": ["T044"], "canonical_name": "protein decanoylation", "definition": "The modification of a protein amino acid by formation of an ester or amide with decanoic acid. [GOC:jsg]"}
{"concept_id": "C1660166", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine octanoylation", "definition": "The octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin. [GOC:jsg, PMID:11546772, RESID:AA0387]"}
{"concept_id": "C1660167", "aliases": [], "types": ["T044"], "canonical_name": "alpha-actinin 3 binding"}
{"concept_id": "C1660168", "aliases": ["adrenaline binding"], "types": ["T044"], "canonical_name": "epinephrine binding", "definition": "Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:ai]"}
{"concept_id": "C1660169", "aliases": ["noradrenaline binding"], "types": ["T044"], "canonical_name": "norepinephrine binding", "definition": "Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. [GOC:ai]"}
{"concept_id": "C1660170", "aliases": ["kinetochore organisation", "kinetochore organization and biogenesis"], "types": ["T045"], "canonical_name": "kinetochore organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1660171", "aliases": ["response to glucocorticoid stimulus"], "types": ["T043"], "canonical_name": "response to glucocorticoid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:ai, PMID:9884123]"}
{"concept_id": "C1660172", "aliases": ["regulation of NGF receptor signaling pathway", "regulation of nerve growth factor receptor signalling pathway", "regulation of NGF receptor signalling pathway", "regulation of nerve growth factor receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of neurotrophin TRK receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. [GOC:ai]"}
{"concept_id": "C1660173", "aliases": [], "types": ["T043"], "canonical_name": "establishment of cellular localization"}
{"concept_id": "C1660174", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of cellular localization"}
{"concept_id": "C1660175", "aliases": [], "types": ["T043"], "canonical_name": "meiosis II nuclear envelope reassembly"}
{"concept_id": "C1660202", "aliases": [], "types": ["T044"], "canonical_name": "alpha-actinin binding", "definition": "Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. [PMID:10984498, PMID:11699871, PMID:15014165]"}
{"concept_id": "C1660203", "aliases": ["regulation of NGF receptor activity"], "types": ["T044"], "canonical_name": "regulation of nerve growth factor receptor activity", "definition": "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor. [GOC:ai]"}
{"concept_id": "C1660204", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of vesicle localization"}
{"concept_id": "C1660205", "aliases": ["establishment of organelle localisation"], "types": ["T043"], "canonical_name": "establishment of organelle localization", "definition": "The directed movement of an organelle to a specific location. [GOC:ai]"}
{"concept_id": "C1660206", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of organelle localization"}
{"concept_id": "C1660209", "aliases": ["membrane disruption in other organism"], "types": ["T043"], "canonical_name": "membrane disruption in another organism", "definition": "The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism. [GOC:ai]"}
{"concept_id": "C1660210", "aliases": ["extrinsic to external side of plasma membrane", "extrinsic to external leaflet of plasma membrane"], "types": ["T026"], "canonical_name": "extrinsic component of external side of plasma membrane", "definition": "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]"}
{"concept_id": "C1660211", "aliases": ["downregulation of cellular metabolic process", "negative regulation of cellular metabolism", "down-regulation of cellular metabolic process", "down regulation of cellular metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of cellular metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. [GOC:mah]"}
{"concept_id": "C1660212", "aliases": [], "types": ["T043"], "canonical_name": "mating projection biogenesis"}
{"concept_id": "C1660216", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of spindle localization"}
{"concept_id": "C1660217", "aliases": [], "types": ["T043"], "canonical_name": "interaction with symbiont"}
{"concept_id": "C1660218", "aliases": ["induction by virus of host apoptosis", "activation by virus of host apoptosis", "induction by virus of host apoptotic programmed cell death", "activation of apoptosis in host by virus", "induction of apoptosis in host by virus", "activation by virus of host apoptotic programmed cell death"], "types": ["T043"], "canonical_name": "induction by virus of host apoptotic process", "definition": "The set of viral processes that induce an apoptotic process in infected host cells, facilitating release and spread of progeny virions. [GOC:mtg_apoptosis, ISBN:0781718325]"}
{"concept_id": "C1660228", "aliases": [], "types": ["T044"], "canonical_name": "protein retention"}
{"concept_id": "C1660229", "aliases": ["SPB-mediated microtubule nucleation", "spindle pole body-mediated microtubule nucleation", "microtubule nucleation by SPB"], "types": ["T043"], "canonical_name": "microtubule nucleation by spindle pole body", "definition": "The 'de novo' formation of a microtubule, mediated by the spindle pole body. [GOC:ai]"}
{"concept_id": "C1660230", "aliases": ["pullulan 4-glucanohydrolase (isopanose-forming) activity"], "types": ["T044"], "canonical_name": "isopullulanase activity", "definition": "Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose). [EC:3.2.1.57]"}
{"concept_id": "C1660231", "aliases": ["isopanose biosynthetic process", "isopanose biosynthesis"], "types": ["T044"], "canonical_name": "6-alpha-maltosylglucose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose. [GOC:ai]"}
{"concept_id": "C1660233", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-proline 3-dioxygenase activity", "definition": "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2. [GOC:mah]"}
{"concept_id": "C1660248", "aliases": ["up-regulation of axial mesodermal cell fate determination", "up regulation of axial mesodermal cell fate determination", "upregulation of axial mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "positive regulation of axial mesodermal cell fate determination", "definition": "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1660249", "aliases": [], "types": ["T044"], "canonical_name": "PID binding"}
{"concept_id": "C1660250", "aliases": [], "types": ["T044"], "canonical_name": "hormone receptor binding", "definition": "Binding to a receptor for a hormone. [GOC:ai]"}
{"concept_id": "C1660251", "aliases": ["corticotropin-releasing factor receptor binding", "CRHR binding", "CRF receptor binding", "CRH receptor binding", "corticotropin releasing factor receptor binding"], "types": ["T044"], "canonical_name": "corticotropin-releasing hormone receptor binding", "definition": "Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. [GOC:ai]"}
{"concept_id": "C1660252", "aliases": ["type 1 corticotropin releasing factor receptor binding", "CRHR1 binding", "type 1 corticotropin releasing factor receptor ligand", "type 1 corticotropin-releasing factor receptor binding"], "types": ["T044"], "canonical_name": "corticotropin-releasing hormone receptor 1 binding", "definition": "Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system. [PMID:15134857]"}
{"concept_id": "C1660253", "aliases": [], "types": ["T044"], "canonical_name": "BH1 domain binding", "definition": "Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01080]"}
{"concept_id": "C1660254", "aliases": [], "types": ["T044"], "canonical_name": "BH4 domain binding", "definition": "Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein. [InterPro:IPR003093, PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01260, Prosite:PS50063]"}
{"concept_id": "C1660257", "aliases": [], "types": ["T044"], "canonical_name": "protein delipidation", "definition": "The breakage of covalent bonds to detach lipid groups from a protein. [GOC:ai]"}
{"concept_id": "C1660259", "aliases": ["down regulation of cytolysis of cells of another organism", "negative regulation of cytolysis of cells of another organism", "negative regulation of cytolysis in other organism", "downregulation of cytolysis of cells of another organism", "down-regulation of cytolysis of cells of another organism"], "types": ["T043"], "canonical_name": "negative regulation of cytolysis in another organism", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cytolysis of cells in another organism. [GOC:ai]"}
{"concept_id": "C1660261", "aliases": [], "types": ["T044"], "canonical_name": "protein C-terminal methylesterase activity", "definition": "Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol. [PMID:10318862, PMID:8650216]"}
{"concept_id": "C1660262", "aliases": ["PME activity", "protein carboxyl methylesterase activity", "protein methyl-esterase activity", "protein carboxylic ester hydrolase activity"], "types": ["T044"], "canonical_name": "protein methylesterase activity", "definition": "Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol. [GOC:ai]"}
{"concept_id": "C1660263", "aliases": [], "types": ["T026"], "canonical_name": "early endosome lumen", "definition": "The volume enclosed by the membrane of an early endosome. [GOC:mah]"}
{"concept_id": "C1660265", "aliases": [], "types": ["T026"], "canonical_name": "plastid thylakoid lumen", "definition": "The volume enclosed by a plastid thylakoid membrane. [GOC:mah]"}
{"concept_id": "C1660266", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine binding", "definition": "Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1660267", "aliases": ["activation of pseudopodium formation", "upregulation of pseudopodium formation", "up-regulation of pseudopodium formation", "positive regulation of pseudopodium formation", "stimulation of pseudopodium formation", "up regulation of pseudopodium formation"], "types": ["T043"], "canonical_name": "positive regulation of pseudopodium assembly", "definition": "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. [GOC:pg]"}
{"concept_id": "C1660268", "aliases": ["intrinsic to mitochondrial inner membrane"], "types": ["T026"], "canonical_name": "intrinsic component of mitochondrial inner membrane", "definition": "The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1660269", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA 3'-end processing", "definition": "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. [GOC:mah]"}
{"concept_id": "C1660610", "aliases": [], "types": ["T043"], "canonical_name": "attachment of spindle microtubules to kinetochore during meiosis"}
{"concept_id": "C1660612", "aliases": [], "types": ["T043"], "canonical_name": "meiosis I nuclear envelope reassembly"}
{"concept_id": "C1660613", "aliases": ["lyase regulator"], "types": ["T044"], "canonical_name": "regulation of lyase activity", "definition": "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [GOC:ai]"}
{"concept_id": "C1660614", "aliases": ["3',5'-cyclic-AMP phosphodiesterase regulator"], "types": ["T044"], "canonical_name": "cAMP phosphodiesterase regulator"}
{"concept_id": "C1660615", "aliases": ["regulation of 3',5'-cyclic-AMP phosphodiesterase activity"], "types": ["T044"], "canonical_name": "regulation of cAMP phosphodiesterase activity"}
{"concept_id": "C1660616", "aliases": [], "types": ["T044"], "canonical_name": "phosphodiesterase regulator"}
{"concept_id": "C1660618", "aliases": [], "types": ["T040"], "canonical_name": "response to electricity"}
{"concept_id": "C1660619", "aliases": ["negative regulation of 5HT uptake", "down-regulation of serotonin uptake", "negative regulation of 5-hydroxytryptamine uptake", "down regulation of serotonin uptake", "downregulation of serotonin uptake", "negative regulation of serotonin import", "negative regulation of 5-HT uptake"], "types": ["T043"], "canonical_name": "negative regulation of serotonin uptake", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell. [GOC:ai]"}
{"concept_id": "C1660620", "aliases": ["regulation of histamine import"], "types": ["T043"], "canonical_name": "regulation of histamine uptake", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell. [GOC:ai]"}
{"concept_id": "C1660621", "aliases": ["N-trimethylglycine transport"], "types": ["T043"], "canonical_name": "glycine betaine transport", "definition": "The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1660622", "aliases": ["down-regulation of nerve growth factor receptor signaling pathway", "downregulation of nerve growth factor receptor signaling pathway", "negative regulation of NGF receptor signaling pathway", "negative regulation of NGF receptor signalling pathway", "negative regulation of nerve growth factor receptor signalling pathway", "negative regulation of nerve growth factor receptor signaling pathway", "down regulation of nerve growth factor receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of neurotrophin TRK receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. [GOC:ai]"}
{"concept_id": "C1660623", "aliases": ["inhibition of norepinephrine import", "inhibition of levarterenol uptake", "inhibition of noradrenaline uptake"], "types": ["T043"], "canonical_name": "inhibition of norepinephrine uptake", "definition": "Any process that prevents the activation of the directed movement of norepinephrine into a cell. [GOC:ai]"}
{"concept_id": "C1660638", "aliases": ["3',5' cyclic nucleotide phosphodiesterase inhibitor", "negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity", "downregulation of cyclic nucleotide phosphodiesterase activity", "negative regulation of cyclic nucleotide phosphodiesterase activity", "down-regulation of cyclic nucleotide phosphodiesterase activity", "down regulation of cyclic nucleotide phosphodiesterase activity"], "types": ["T044"], "canonical_name": "negative regulation of cyclic-nucleotide phosphodiesterase activity", "definition": "Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. [GOC:ai, GOC:tb]"}
{"concept_id": "C1660639", "aliases": ["ligase inhibitor", "down-regulation of ligase activity", "downregulation of ligase activity", "down regulation of ligase activity"], "types": ["T044"], "canonical_name": "negative regulation of ligase activity", "definition": "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. [GOC:ai]"}
{"concept_id": "C1660640", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein", "definition": "The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan. [PMID:8163519, PMID:9086265, RESID:AA0383]"}
{"concept_id": "C1660641", "aliases": ["organelle localisation", "establishment and maintenance of organelle localization"], "types": ["T038"], "canonical_name": "organelle localization", "definition": "Any process in which an organelle is transported to, and/or maintained in, a specific location. [GOC:ai]"}
{"concept_id": "C1660642", "aliases": ["establishment and maintenance of localization in cell or cell membrane", "establishment and maintenance of cellular localization", "cellular localisation"], "types": ["T043"], "canonical_name": "cellular localization", "definition": "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. [GOC:tb, GOC:vw]"}
{"concept_id": "C1660644", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-17 receptor ligand"}
{"concept_id": "C1660645", "aliases": [], "types": ["T044"], "canonical_name": "linoleic acid desaturase activity"}
{"concept_id": "C1660646", "aliases": ["MPBQ methyltransferase activity"], "types": ["T044"], "canonical_name": "2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity", "definition": "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine. [MetaCyc:RXN-2542]"}
{"concept_id": "C1660648", "aliases": [], "types": ["T043"], "canonical_name": "regulation of collateral sprouting of intact axon in response to injury", "definition": "Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1660649", "aliases": [], "types": ["T042"], "canonical_name": "epidermis morphogenesis", "definition": "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. [GOC:jid, UBERON:0001003]"}
{"concept_id": "C1660739", "aliases": [], "types": ["T042"], "canonical_name": "R1/R6 cell differentiation", "definition": "The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster. [GOC:jid]"}
{"concept_id": "C1660740", "aliases": [], "types": ["T042"], "canonical_name": "compound eye corneal lens development", "definition": "The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells. [GOC:jid]"}
{"concept_id": "C1660741", "aliases": ["protein sequestering"], "types": ["T044"], "canonical_name": "protein sequestering"}
{"concept_id": "C1660742", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-proline N-formylation", "definition": "The formylation of the N-terminal proline of proteins to form the derivative N-formylproline. [PMID:12051774, PMID:5464655, RESID:AA0384]"}
{"concept_id": "C1660743", "aliases": ["cellular response to potassium starvation", "cellular response to potassium ion deprivation", "cellular response to K+ ion starvation", "cellular response to K+ ion deprivation"], "types": ["T043"], "canonical_name": "cellular response to potassium ion starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions. [GOC:sm]"}
{"concept_id": "C1660744", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine decanoylation", "definition": "The decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin. [GOC:jsg, PMID:12630926, RESID:AA0385]"}
{"concept_id": "C1660745", "aliases": ["alpha-actinin 4 binding"], "types": ["T044"], "canonical_name": "nonmuscle alpha-actinin binding"}
{"concept_id": "C1660746", "aliases": [], "types": ["T044"], "canonical_name": "alpha-actinin 1 binding"}
{"concept_id": "C1660749", "aliases": ["intracellular localization"], "types": ["T043"], "canonical_name": "localization within cell"}
{"concept_id": "C1660750", "aliases": ["centrosome localisation", "establishment and maintenance of centrosome localization"], "types": ["T038"], "canonical_name": "centrosome localization", "definition": "Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]"}
{"concept_id": "C1660751", "aliases": [], "types": ["T043"], "canonical_name": "cellular retention"}
{"concept_id": "C1660752", "aliases": ["intracellular sequestering"], "types": ["T043"], "canonical_name": "sequestering within cell"}
{"concept_id": "C1660753", "aliases": ["peptide ABC transporter"], "types": ["T044"], "canonical_name": "ABC-type peptide transporter activity", "definition": "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria. [RHEA:14429]"}
{"concept_id": "C1660767", "aliases": [], "types": ["T043"], "canonical_name": "neuronal ion channel clustering", "definition": "The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. [PMID:11456440]"}
{"concept_id": "C1660770", "aliases": ["Bcl-2 homology domain binding"], "types": ["T044"], "canonical_name": "BH domain binding", "definition": "Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409]"}
{"concept_id": "C1660771", "aliases": ["neuronal cell programmed cell death by apoptosis", "programmed cell death, neurons", "apoptosis of neurons", "neuron apoptotic process", "neuron programmed cell death by apoptosis", "neuron apoptosis", "neuronal cell apoptosis", "programmed cell death of neurons by apoptosis", "programmed cell death, neuronal cells", "programmed cell death of neuronal cells by apoptosis"], "types": ["T043"], "definition": "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis, MeSH:A.08.663]", "canonical_name": "apoptosis of neuronal cells"}
{"concept_id": "C1660772", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of nucleus localization"}
{"concept_id": "C1660773", "aliases": ["lipid raft localization", "membrane raft localisation", "establishment and maintenance of membrane raft localization"], "types": ["T043"], "canonical_name": "membrane raft localization", "definition": "Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. [GOC:ai, PMID:16645198]"}
{"concept_id": "C1660776", "aliases": [], "types": ["T026"], "canonical_name": "platelet dense tubular network", "definition": "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. [PMID:1322202]"}
{"concept_id": "C1660777", "aliases": [], "types": ["T045"], "canonical_name": "rRNA pseudouridine synthesis", "definition": "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule. [GOC:mah]"}
{"concept_id": "C1660778", "aliases": ["integral to plastid membrane"], "types": ["T026"], "canonical_name": "integral component of plastid membrane", "definition": "The component of the plastid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C1660779", "aliases": ["oxylipin metabolism"], "types": ["T044"], "canonical_name": "oxylipin metabolic process", "definition": "The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. [GOC:mah, PMID:11960741]"}
{"concept_id": "C1660780", "aliases": [], "types": ["T026"], "canonical_name": "midline"}
{"concept_id": "C1660781", "aliases": ["upregulation of synaptic vesicle fusion to presynaptic membrane", "positive regulation of synaptic vesicle fusion to pre-synaptic membrane", "up-regulation of synaptic vesicle fusion to presynaptic active zone membrane", "positive regulation of synaptic vesicle fusion to presynaptic active zone membrane", "up regulation of synaptic vesicle fusion to presynaptic membrane", "up regulation of synaptic vesicle fusion to presynaptic active zone membrane"], "types": ["T043"], "definition": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. [GOC:mah]", "canonical_name": "up-regulation of synaptic vesicle fusion to presynaptic membrane"}
{"concept_id": "C1660782", "aliases": ["up-regulation of behavior", "upregulation of behavior", "up regulation of behavior"], "types": ["T040"], "canonical_name": "positive regulation of behavior", "definition": "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. [GOC:jid, GOC:pr]"}
{"concept_id": "C1660783", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of metalloenzyme activity"}
{"concept_id": "C1660784", "aliases": [], "types": ["T044"], "canonical_name": "triterpene catabolism"}
{"concept_id": "C1660799", "aliases": ["dihydroxyacetone-phosphate:inorganic phosphate antiporter activity"], "types": ["T044"], "canonical_name": "glycerone phosphate:inorganic phosphate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out). [GOC:ai]"}
{"concept_id": "C1660800", "aliases": ["detoxification of nitrogenous compound"], "types": ["T040"], "canonical_name": "detoxification of nitrogen compound", "definition": "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. [GOC:ai]"}
{"concept_id": "C1660801", "aliases": ["response to cortisone stimulus"], "types": ["T043"], "canonical_name": "response to cortisone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues. [ISBN:0721662544, PMID:11276391]"}
{"concept_id": "C1660802", "aliases": ["response to hydrocortisone stimulus", "response to cortisol stimulus"], "types": ["T043"], "canonical_name": "response to cortisol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions. [ISBN:0721662544, PMID:11276391]"}
{"concept_id": "C1660804", "aliases": [], "types": ["T038"], "canonical_name": "cytolysis, by membrane disruption, in other organism"}
{"concept_id": "C1660806", "aliases": ["isopanose catabolic process", "isopanose catabolism"], "types": ["T043"], "canonical_name": "6-alpha-maltosylglucose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose. [GOC:ai]"}
{"concept_id": "C1660807", "aliases": ["establishment of ER localisation", "establishment of endoplasmic reticulum localization"], "types": ["T043"], "definition": "The directed movement of the endoplasmic reticulum to a specific location. [GOC:ai]", "canonical_name": "establishment of ER localization"}
{"concept_id": "C1660808", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of plastid localization"}
{"concept_id": "C1660809", "aliases": ["cellular oligosaccharide metabolism"], "types": ["T044"], "canonical_name": "cellular oligosaccharide metabolic process", "definition": "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells. [GOC:ai]"}
{"concept_id": "C1660823", "aliases": [], "types": ["T044"], "canonical_name": "adenylate cyclase regulator"}
{"concept_id": "C1660824", "aliases": ["downregulation of axial mesodermal cell fate determination", "down regulation of axial mesodermal cell fate determination", "down-regulation of axial mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "negative regulation of axial mesodermal cell fate determination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1660825", "aliases": [], "types": ["T043"], "canonical_name": "regulation of axial mesodermal cell fate specification", "definition": "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1660826", "aliases": ["endo-1,4-beta-xylanase regulator"], "types": ["T044"], "canonical_name": "xylanase regulator"}
{"concept_id": "C1660832", "aliases": [], "types": ["T044"], "canonical_name": "saccharopine oxidase activity", "definition": "Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2. [PMID:16233628]"}
{"concept_id": "C1660833", "aliases": [], "types": ["T044"], "canonical_name": "proline oxidase activity", "definition": "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2. [MetaCyc:RXN-821]"}
{"concept_id": "C1660834", "aliases": ["FAOD activity"], "types": ["T044"], "canonical_name": "fructosyl-amino acid oxidase activity", "definition": "Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2. [PMID:16233628]"}
{"concept_id": "C1660835", "aliases": ["intraspecies interaction between organisms", "intraspecies interaction with other organisms"], "types": ["T038"], "canonical_name": "biological process involved in intraspecies interaction between organisms", "definition": "Any process in which an organism has an effect on an organism of the same species. [GOC:ai]"}
{"concept_id": "C1660837", "aliases": [], "types": ["T040"], "canonical_name": "response to other organism", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. [GOC:ai]"}
{"concept_id": "C1660838", "aliases": ["inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity", "inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity", "inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity"], "types": ["T044"], "canonical_name": "inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity", "definition": "Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. [GOC:bf, MetaCyc:3.1.3.62-RXN]"}
{"concept_id": "C1660839", "aliases": [], "types": ["T043"], "canonical_name": "Mad2-dependent checkpoint"}
{"concept_id": "C1660840", "aliases": [], "types": ["T026"], "canonical_name": "chromoplast inner membrane", "definition": "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma. [GOC:pz]"}
{"concept_id": "C1660842", "aliases": ["L-ornithine 5-monooxygenase activity"], "types": ["T044"], "canonical_name": "ornithine N5-monooxygenase activity", "definition": "Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O. [MetaCyc:RXN-11128, PMID:12828635]"}
{"concept_id": "C1661191", "aliases": ["negative regulation of syncytial blastoderm cell cycle progression", "negative regulation of progression through syncytial blastoderm mitotic cell cycle", "down regulation of progression through syncytial blastoderm mitotic cell cycle", "down-regulation of progression through syncytial blastoderm mitotic cell cycle", "downregulation of progression through syncytial blastoderm mitotic cell cycle"], "types": ["T043"], "canonical_name": "negative regulation of syncytial blastoderm mitotic cell cycle", "definition": "Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1661193", "aliases": ["down regulation of ubiquitin transferase activity", "down-regulation of ubiquitin transferase activity", "downregulation of ubiquitin transferase activity", "negative regulation of ubiquitin transferase activity"], "types": ["T044"], "canonical_name": "negative regulation of ubiquitin-protein transferase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity. [GOC:ai, GOC:tb]"}
{"concept_id": "C1661194", "aliases": [], "types": ["T026"], "canonical_name": "APC inhibitor"}
{"concept_id": "C1661197", "aliases": ["MSBQ methyltransferase activity"], "types": ["T044"], "canonical_name": "2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity", "definition": "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine. [MetaCyc:RXN-2762]"}
{"concept_id": "C1661198", "aliases": ["RCC reductase activity"], "types": ["T044"], "canonical_name": "red chlorophyll catabolite reductase activity", "definition": "Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence. [PMID:10743659]"}
{"concept_id": "C1661199", "aliases": ["integral to contractile vacuolar membrane"], "types": ["T026"], "canonical_name": "integral component of contractile vacuolar membrane", "definition": "The component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer. [GOC:dos, GOC:pg]"}
{"concept_id": "C1661200", "aliases": [], "types": ["T026"], "canonical_name": "carboxysome", "definition": "An organelle consisting of a proteinaceous coat and enzymes for the fixation of CO(2). It augments the concentration of CO(2) in the vicinity of RuBisCO to increase the efficiency of CO(2) fixation under atmospheric conditions. [GOC:js, PMID:28934381, PMID:8157606, PMID:8491708]"}
{"concept_id": "C1661774", "aliases": ["up-regulation of lateral mesodermal cell fate determination", "positive regulation of lateral plate mesodermal cell fate determination", "up regulation of lateral mesodermal cell fate determination", "upregulation of lateral mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "positive regulation of lateral mesodermal cell fate determination", "definition": "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination. [GOC:jid]"}
{"concept_id": "C1661775", "aliases": ["up regulation of lateral mesodermal cell fate specification", "positive regulation of lateral plate mesodermal cell fate specification", "upregulation of lateral mesodermal cell fate specification", "up-regulation of lateral mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "positive regulation of lateral mesodermal cell fate specification", "definition": "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification. [GOC:jid]"}
{"concept_id": "C1661776", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intermediate mesodermal cell fate specification", "definition": "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1662128", "aliases": [], "types": ["T043"], "canonical_name": "APC inhibition"}
{"concept_id": "C1662129", "aliases": [], "types": ["T026"], "canonical_name": "SCF complex inhibitor"}
{"concept_id": "C1662130", "aliases": ["anaphase promoting complex inhibition"], "types": ["T043"], "canonical_name": "anaphase-promoting complex inhibition"}
{"concept_id": "C1662131", "aliases": ["GnRH binding", "gonadotrophin releasing hormone binding"], "types": ["T044"], "canonical_name": "gonadotropin-releasing hormone binding", "definition": "Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. [GOC:pr, PMID:1984190]"}
{"concept_id": "C1662132", "aliases": ["GTP-dependent DNA 5'-hydroxyl-kinase activity", "GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity", "GTP-dependent polydeoxyribonucleotide kinase activity", "GTP-dependent DNA kinase activity"], "types": ["T044"], "canonical_name": "GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "definition": "Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA. [EC:2.7.1.78, PMID:8428918]"}
{"concept_id": "C1662133", "aliases": [], "types": ["T044"], "canonical_name": "3,8-divinyl protochlorophyllide a 8-vinyl reductase activity", "definition": "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+. [MetaCyc:RXN1F-72]"}
{"concept_id": "C1662134", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelial cell proliferation", "definition": "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. [GOC:add]"}
{"concept_id": "C1662135", "aliases": [], "types": ["T039"], "canonical_name": "regulation of respiratory gaseous exchange", "definition": "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. [GOC:jl]"}
{"concept_id": "C1662203", "aliases": [], "types": ["T042"], "canonical_name": "paraxial mesodermal cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:dgh]"}
{"concept_id": "C1662204", "aliases": [], "types": ["T042"], "canonical_name": "regulation of paraxial mesodermal cell fate determination", "definition": "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1662205", "aliases": ["up regulation of paraxial mesodermal cell fate specification", "upregulation of paraxial mesodermal cell fate specification", "up-regulation of paraxial mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "positive regulation of paraxial mesodermal cell fate specification", "definition": "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1662206", "aliases": ["regulation of ubiquitin transferase activity"], "types": ["T044"], "canonical_name": "regulation of ubiquitin-protein transferase activity", "definition": "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity. [GOC:ai, GOC:tb]"}
{"concept_id": "C1662216", "aliases": [], "types": ["T044"], "canonical_name": "potassium ABC transporter"}
{"concept_id": "C1662217", "aliases": ["regulation of anthocyanin metabolism"], "types": ["T044"], "canonical_name": "regulation of anthocyanin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. [GOC:mah]"}
{"concept_id": "C1662575", "aliases": ["positive regulation of progression through syncytial blastoderm mitotic cell cycle", "up regulation of progression through syncytial blastoderm mitotic cell cycle", "positive regulation of syncytial blastoderm cell cycle progression", "upregulation of progression through syncytial blastoderm mitotic cell cycle", "up-regulation of progression through syncytial blastoderm mitotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of syncytial blastoderm mitotic cell cycle", "definition": "Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1662577", "aliases": ["down-regulation of lateral mesodermal cell fate determination", "down regulation of lateral mesodermal cell fate determination", "negative regulation of lateral plate mesodermal cell fate determination", "downregulation of lateral mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "negative regulation of lateral mesodermal cell fate determination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate determination. [GOC:jid]"}
{"concept_id": "C1662578", "aliases": ["down-regulation of intermediate mesodermal cell fate specification", "downregulation of intermediate mesodermal cell fate specification", "down regulation of intermediate mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of intermediate mesodermal cell fate specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1662580", "aliases": ["up-regulation of progression through meiotic cell cycle", "upregulation of progression through meiotic cell cycle", "up regulation of progression through meiotic cell cycle", "positive regulation of progression through meiotic cell cycle", "positive regulation of meiotic cell cycle progression"], "types": ["T044"], "canonical_name": "positive regulation of meiotic cell cycle", "definition": "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1662581", "aliases": [], "types": ["T043"], "canonical_name": "myoblast proliferation", "definition": "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ai, GOC:mtg_muscle]"}
{"concept_id": "C1662582", "aliases": ["5'-hydroxyl RNA kinase activity", "RNA kinase activity", "RNA 5'-hydroxyl kinase activity", "5'-hydroxyl polyribonucleotide kinase activity"], "types": ["T044"], "canonical_name": "polyribonucleotide kinase activity", "definition": "Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA. [GOC:curators]"}
{"concept_id": "C1662583", "aliases": [], "types": ["T040"], "canonical_name": "taxis in response to mechanical stimulus"}
{"concept_id": "C1662584", "aliases": [], "types": ["T045"], "canonical_name": "tRNA pseudouridine synthesis", "definition": "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. [GOC:mah]"}
{"concept_id": "C1662585", "aliases": ["extrinsic to internal leaflet of plasma membrane", "extrinsic to internal side of plasma membrane"], "types": ["T026"], "canonical_name": "extrinsic component of cytoplasmic side of plasma membrane", "definition": "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. [GOC:mah]"}
{"concept_id": "C1662586", "aliases": [], "types": ["T044"], "canonical_name": "active protein retrieval"}
{"concept_id": "C1662963", "aliases": ["down regulation of progression through embryonic mitotic cell cycle", "negative regulation of embryonic mitotic cell cycle", "negative regulation of progression through embryonic mitotic cell cycle", "downregulation of progression through embryonic mitotic cell cycle", "down-regulation of progression through embryonic mitotic cell cycle", "negative regulation of embryonic mitotic cell cycle progression"], "types": ["T043"], "canonical_name": "negative regulation of mitotic cell cycle, embryonic", "definition": "Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1662964", "aliases": ["up-regulation of mesodermal cell fate specification", "upregulation of mesodermal cell fate specification", "up regulation of mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "positive regulation of mesodermal cell fate specification", "definition": "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1662965", "aliases": ["down-regulation of paraxial mesodermal cell fate determination", "down regulation of paraxial mesodermal cell fate determination", "downregulation of paraxial mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "negative regulation of paraxial mesodermal cell fate determination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1662966", "aliases": [], "types": ["T026"], "canonical_name": "anaphase-promoting complex regulator"}
{"concept_id": "C1662973", "aliases": [], "types": ["T042"], "canonical_name": "sebaceous gland development", "definition": "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1662975", "aliases": [], "types": ["T040"], "canonical_name": "heat dissipation", "definition": "Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature. [GOC:mah]"}
{"concept_id": "C1664962", "aliases": ["down-regulation of progression through preblastoderm mitotic cell cycle", "negative regulation of preblastoderm mitotic cell cycle progression", "negative regulation of progression through preblastoderm mitotic cell cycle", "down regulation of progression through preblastoderm mitotic cell cycle", "downregulation of progression through preblastoderm mitotic cell cycle"], "types": ["T043"], "canonical_name": "negative regulation of preblastoderm mitotic cell cycle", "definition": "Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C1664963", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intermediate mesodermal cell fate determination", "definition": "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1664964", "aliases": ["upregulation of intermediate mesodermal cell fate determination", "up regulation of intermediate mesodermal cell fate determination", "up-regulation of intermediate mesodermal cell fate determination"], "types": ["T043"], "canonical_name": "positive regulation of intermediate mesodermal cell fate determination", "definition": "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination. [GOC:dgh]"}
{"concept_id": "C1664965", "aliases": ["up regulation of intermediate mesodermal cell fate specification", "up-regulation of intermediate mesodermal cell fate specification", "upregulation of intermediate mesodermal cell fate specification"], "types": ["T043"], "canonical_name": "positive regulation of intermediate mesodermal cell fate specification", "definition": "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification. [GOC:dgh]"}
{"concept_id": "C1664966", "aliases": [], "types": ["T026"], "canonical_name": "SCF complex activator"}
{"concept_id": "C1664969", "aliases": ["anaphase promoting complex inhibitor"], "types": ["T026"], "canonical_name": "anaphase-promoting complex inhibitor"}
{"concept_id": "C1664970", "aliases": [], "types": ["T026"], "canonical_name": "meiotic cell cycle regulator"}
{"concept_id": "C1664971", "aliases": ["down-regulation of progression through meiotic cell cycle", "down regulation of progression through meiotic cell cycle", "negative regulation of progression through meiotic cell cycle", "negative regulation of meiotic cell cycle progression", "downregulation of progression through meiotic cell cycle"], "types": ["T044"], "canonical_name": "negative regulation of meiotic cell cycle", "definition": "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1664972", "aliases": ["DNA kinase activity", "DNA 5'-hydroxyl kinase activity"], "types": ["T044"], "canonical_name": "polydeoxyribonucleotide kinase activity", "definition": "Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA. [GOC:curators]"}
{"concept_id": "C1664973", "aliases": [], "types": ["T044"], "canonical_name": "xanthophyll binding", "definition": "Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen. [ISBN:0122146743]"}
{"concept_id": "C1664974", "aliases": ["ethene binding"], "types": ["T044"], "canonical_name": "ethylene binding", "definition": "Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. [GOC:ai]"}
{"concept_id": "C1664975", "aliases": ["isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity", "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity"], "types": ["T044"], "canonical_name": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity", "definition": "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. [EC:1.17.7.4]"}
{"concept_id": "C1664976", "aliases": ["DNA demethylase activity"], "types": ["T044"], "canonical_name": "DNA demethylase activity", "definition": "Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule. [GOC:bf]"}
{"concept_id": "C1707313", "aliases": [], "types": ["T044"], "definition": "Any apoptotic process that does not involve pathways that activate intracellular proteolytic caspases.", "canonical_name": "caspase-independent apoptosis"}
{"concept_id": "C1709317", "aliases": [], "types": ["T043"], "definition": "A cellular process characteristic of necrotic cell death, resulting in swelling of the cell body.", "canonical_name": "oncosis"}
{"concept_id": "C1711228", "aliases": [], "types": ["T043"], "definition": "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. [GOC:dph, GOC:tb]", "canonical_name": "regulation of cell death"}
{"concept_id": "C1720892", "aliases": [], "types": ["T042"], "definition": "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]", "canonical_name": "digestive system process"}
{"concept_id": "C1744604", "aliases": [], "types": ["T038"], "definition": "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. [GOC:dph, GOC:jid]", "canonical_name": "system development"}
{"concept_id": "C1744639", "aliases": ["interferon-alpha/beta receptor binding"], "types": ["T044"], "canonical_name": "type I interferon receptor binding", "definition": "Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). [GOC:ai, GOC:signaling, PMID:17502368]"}
{"concept_id": "C1744640", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-11 receptor. [GOC:ai]", "canonical_name": "interleukin-11 receptor binding"}
{"concept_id": "C1744641", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-12 receptor. [GOC:ai]", "canonical_name": "interleukin-12 receptor binding"}
{"concept_id": "C1744642", "aliases": [], "types": ["T044"], "definition": "Binding to an interleukin-13 receptor. [GOC:ai]", "canonical_name": "interleukin-13 receptor binding"}
{"concept_id": "C1744643", "aliases": [], "types": ["T044"], "definition": "Binding to an oncostatin-M receptor. [GOC:ai]", "canonical_name": "oncostatin-M receptor binding"}
{"concept_id": "C1744644", "aliases": [], "types": ["T044"], "canonical_name": "prolactin"}
{"concept_id": "C1744645", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-1, type I receptor binding", "definition": "Binding to a Type I interleukin-1 receptor. [GOC:ai]"}
{"concept_id": "C1744646", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-1, type II receptor binding", "definition": "Binding to a Type II interleukin-1 receptor. [GOC:ai]"}
{"concept_id": "C1744647", "aliases": ["1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity", "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity", "diadenosine P1,P4-tetraphosphatase activity", "dinucleoside tetraphosphatase activity", "dinucleosidetetraphosphatase (asymmetrical) activity", "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity", "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity"], "types": ["T044"], "canonical_name": "bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity", "definition": "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate. [EC:3.6.1.17, PMID:4955726]"}
{"concept_id": "C1744648", "aliases": [], "types": ["T044"], "canonical_name": "myosin phosphatase regulator activity", "definition": "Binds to and modulates of the activity of myosin phosphatase. [GOC:ai, PMID:10491107]"}
{"concept_id": "C1744649", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 2A regulator activity"}
{"concept_id": "C1744650", "aliases": [], "types": ["T044"], "canonical_name": "[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity", "definition": "Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase. [EC:3.1.3.43, GOC:ai]"}
{"concept_id": "C1744651", "aliases": [], "types": ["T044"], "canonical_name": "protein tyrosine/serine/threonine phosphatase activity", "definition": "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]"}
{"concept_id": "C1744652", "aliases": [], "types": ["T044"], "canonical_name": "APG8-specific protease activity"}
{"concept_id": "C1744656", "aliases": [], "types": ["T044"], "canonical_name": "phosphorylase kinase regulator activity", "definition": "Modulation of the activity of the enzyme phosphorylase kinase. [GOC:curators]"}
{"concept_id": "C1744657", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-dependent protein kinase activating kinase regulator activity", "definition": "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase. [GOC:ai]"}
{"concept_id": "C1744658", "aliases": [], "types": ["T044"], "canonical_name": "protein threonine/tyrosine kinase activity"}
{"concept_id": "C1744659", "aliases": ["(R)-oxynitrilase activity", "mandelonitrile benzaldehyde-lyase activity", "mandelonitrile benzaldehyde-lyase (cyanide-forming)", "D-oxynitrilase activity", "D-alpha-hydroxynitrile lyase activity"], "types": ["T044"], "canonical_name": "mandelonitrile lyase activity", "definition": "Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde. [EC:4.1.2.10]"}
{"concept_id": "C1744661", "aliases": ["hydrogenase (ferredoxin) activity", "[Fe] hydrogenase activity", "hydrogen:ferredoxin oxidoreductase activity"], "types": ["T044"], "canonical_name": "ferredoxin hydrogenase activity", "definition": "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2. [EC:1.12.7.2]"}
{"concept_id": "C1744662", "aliases": [], "types": ["T044"], "canonical_name": "copper, zinc superoxide dismutase activity"}
{"concept_id": "C1744663", "aliases": ["UBE1L"], "types": ["T044"], "definition": "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:mah]", "canonical_name": "ISG15 activating enzyme activity"}
{"concept_id": "C1744666", "aliases": ["cell-cell adhesion during conjugation with cellular fusion", "cell-cell adhesion during mating"], "types": ["T043"], "canonical_name": "agglutination involved in conjugation with cellular fusion", "definition": "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation with cellular fusion of a unicellular organism. An example of this process is agglutination in Saccharomyces cerevisiae. [GOC:elh]"}
{"concept_id": "C1744668", "aliases": ["L-arabitol breakdown to xylulose 5-phosphate", "L-arabitol degradation to xylulose 5-phosphate"], "types": ["T044"], "canonical_name": "L-arabitol catabolic process to xylulose 5-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate. [MetaCyc:LARABITOLUTIL-PWY]"}
{"concept_id": "C1744669", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis during DNA repair"}
{"concept_id": "C1744671", "aliases": ["SR complex location", "signal recognition particle receptor complex location", "signal recognition particle receptor complex"], "types": ["T026"], "definition": "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex. [ISBN:0198506732]", "canonical_name": "SR complex"}
{"concept_id": "C1744672", "aliases": ["conserved oligomeric Golgi complex", "conserved oligomeric Golgi complex location", "COG complex", "Golgi transport complex location", "COG complex location"], "types": ["T026"], "canonical_name": "Golgi transport complex", "definition": "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8. [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]"}
{"concept_id": "C1744673", "aliases": ["TIM23 mitochondrial import inner membrane translocase complex location", "mitochondrial inner membrane translocase complex", "Tim23 complex", "TIM23 mitochondrial import inner membrane translocase complex", "mitochondrial inner membrane presequence translocase complex location", "Tim23 complex location", "mitochondrial inner membrane translocase complex location", "mitochondrial inner membrane pre-sequence translocase complex", "mitochondrial inner membrane presequence translocase complex"], "types": ["T026"], "definition": "The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. [EC:7.4.2.3, PMID:27554484, PMID:8851659]", "canonical_name": "mitochondrial inner membrane pre-sequence translocase complex location"}
{"concept_id": "C1744674", "aliases": ["RNA polymerase I upstream activating factor complex location", "RNA polymerase I upstream activating factor complex", "RNA polymerase I upstream activation factor complex", "RNA polymerase I upstream activation factor complex location"], "types": ["T026"], "definition": "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p. [PMID:11500378]", "canonical_name": "UAF"}
{"concept_id": "C1744675", "aliases": ["DNA polymerase alpha:primase complex", "alpha DNA polymerase:primase complex location", "DNA polymerase alpha:primase complex location", "heterotetrameric polymerase alpha holoenzyme"], "types": ["T026"], "canonical_name": "alpha DNA polymerase:primase complex", "definition": "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis. [GOC:mah, PMID:11395402, PMID:26975377]"}
{"concept_id": "C1744676", "aliases": ["light-harvesting complex location"], "types": ["T026"], "canonical_name": "light-harvesting complex", "definition": "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. [GOC:lr]"}
{"concept_id": "C1744677", "aliases": ["ferredoxin hydrogenase complex location"], "types": ["T026"], "canonical_name": "ferredoxin hydrogenase complex", "definition": "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances. [EC:1.12.7.2]"}
{"concept_id": "C1744684", "aliases": [], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor ligand"}
{"concept_id": "C1744691", "aliases": ["localization", "establishment and maintenance of substance location", "localisation", "establishment and maintenance of localization", "establishment and maintenance of position", "establishment and maintenance of cellular component location"], "types": ["T038"], "definition": "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. [GOC:ai, GOC:dos]", "canonical_name": "establishment and maintenance of substrate location"}
{"concept_id": "C1744692", "aliases": ["nitric oxide synthase inhibitor activity", "nitric-oxide synthase inhibitor", "NOS inhibitor activity", "nitric-oxide synthase inhibitor activity"], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of nitric oxide synthase. [GOC:BHF, GOC:rl, PMID:17242280]", "canonical_name": "NOS inhibitor"}
{"concept_id": "C1748457", "aliases": [], "types": ["T045"], "canonical_name": "pyrimidine-dimer repair by photolyase"}
{"concept_id": "C1748459", "aliases": [], "types": ["T043"], "canonical_name": "nuclear migration during conjugation with cellular fusion"}
{"concept_id": "C1748461", "aliases": ["conjugation with cellular fusion"], "types": ["T043"], "definition": "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae. [GOC:elh]", "canonical_name": "mating"}
{"concept_id": "C1748467", "aliases": [], "types": ["T043"], "canonical_name": "a-factor export"}
{"concept_id": "C1748468", "aliases": [], "types": ["T026"], "canonical_name": "condensed chromosome, centromere"}
{"concept_id": "C1748473", "aliases": ["cytoplasmic ORC", "cytoplasmic origin of replication recognition complex location"], "types": ["T026"], "canonical_name": "cytoplasmic origin of replication recognition complex", "definition": "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm. [GOC:elh]"}
{"concept_id": "C1748478", "aliases": ["haploid fruiting", "homokaryotic fruiting"], "types": ["T040"], "canonical_name": "monokaryotic fruiting"}
{"concept_id": "C1748480", "aliases": ["cytokinesis, actomyosin ring biosynthesis"], "types": ["T043"], "canonical_name": "cytokinesis, actomyosin ring formation"}
{"concept_id": "C1748484", "aliases": [], "types": ["T026"], "canonical_name": "porous septum"}
{"concept_id": "C1748485", "aliases": [], "types": ["T026"], "canonical_name": "primary cell septum", "definition": "A cell septum that forms following nuclear division. [GOC:clt, ISBN:0471940526]"}
{"concept_id": "C1748487", "aliases": [], "types": ["T026"], "canonical_name": "outer kinetochore plate"}
{"concept_id": "C1748488", "aliases": [], "types": ["T044"], "canonical_name": "serine exchange enzyme"}
{"concept_id": "C1748490", "aliases": [], "types": ["T044"], "canonical_name": "aminophospholipid-transporting ATPase"}
{"concept_id": "C1748496", "aliases": ["proteoglycan sulphotransferase activity"], "types": ["T044"], "canonical_name": "proteoglycan sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans. [EC:2.8.2.-, GOC:ai]"}
{"concept_id": "C1748499", "aliases": ["cell adhesion receptor activity"], "types": ["T044"], "canonical_name": "cell adhesion receptor activity", "definition": "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins. [GOC:BHF-UCL, Wikipedia:Cell_adhesion]"}
{"concept_id": "C1748500", "aliases": ["sensory transduction of heat stimulus during thermoception", "thermoception, sensory transduction of heat stimulus", "sensory detection of heat stimulus during thermoception", "sensory detection of hot stimulus during thermoception", "thermoception, sensory transduction of hot stimulus", "sensory transduction of hot stimulus during thermoception", "thermoception, sensory detection of hot stimulus", "thermoception, sensory detection of heat stimulus"], "types": ["T040"], "canonical_name": "detection of hot stimulus involved in thermoception", "definition": "The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception. [PMID:21335241]"}
{"concept_id": "C1748503", "aliases": ["sensory transduction of heat stimulus during sensory perception"], "types": ["T038"], "canonical_name": "sensory perception, sensory transduction of heat stimulus"}
{"concept_id": "C1748504", "aliases": ["deoxyhypusine synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+. [GOC:pde, RHEA:33299]", "canonical_name": "eIF-5A-deoxyhypusine synthase activity"}
{"concept_id": "C1748509", "aliases": [], "types": ["T043"], "canonical_name": "striated muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. [CL:0000737, GOC:ai]"}
{"concept_id": "C1748513", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of calcium ion (Ca2+) transport"}
{"concept_id": "C1748514", "aliases": [], "types": ["T043"], "canonical_name": "isotropic cell growth", "definition": "The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth. [GOC:ai, GOC:jid]"}
{"concept_id": "C1748519", "aliases": [], "types": ["T044"], "canonical_name": "3',5'-cyclic-AMP phosphodiesterase inhibitor"}
{"concept_id": "C1748520", "aliases": [], "types": ["T044"], "canonical_name": "cAMP phosphodiesterase inhibitor"}
{"concept_id": "C1748521", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity"}
{"concept_id": "C1748522", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cAMP phosphodiesterase activity"}
{"concept_id": "C1748524", "aliases": ["positive regulation of ubiquitin transferase activity", "upregulation of ubiquitin transferase activity", "up-regulation of ubiquitin transferase activity"], "types": ["T044"], "canonical_name": "positive regulation of ubiquitin-protein transferase activity", "definition": "Any process that activates, maintains or increases the rate of ubiquitin transferase activity. [GOC:ai, GOC:tb]"}
{"concept_id": "C1748600", "aliases": ["G-CSF binding", "granulocyte colony-stimulating factor binding", "granulocyte colony-stimulating factor"], "types": ["T044"], "definition": "Binding to granulocyte colony-stimulating factor, G-CSF. [GOC:ai]", "canonical_name": "granulocyte colony stimulating factor binding"}
{"concept_id": "C1749308", "aliases": ["endotoxin binding"], "types": ["T044"], "canonical_name": "endotoxin binding"}
{"concept_id": "C1749309", "aliases": [], "types": ["T042"], "canonical_name": "ovarian cumulus growth"}
{"concept_id": "C1749317", "aliases": ["G-protein coupled receptor binding", "G protein coupled receptor binding"], "types": ["T044"], "canonical_name": "G protein-coupled receptor binding", "definition": "Binding to a G protein-coupled receptor. [GOC:ceb, GOC:dph]"}
{"concept_id": "C1749318", "aliases": [], "types": ["T042"], "canonical_name": "establishment of planar polarity", "definition": "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates. [GOC:dph]"}
{"concept_id": "C1749323", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP27B"}
{"concept_id": "C1749325", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP11B1"}
{"concept_id": "C1749326", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP11B2"}
{"concept_id": "C1749327", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP17"}
{"concept_id": "C1749328", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP21A1"}
{"concept_id": "C1749340", "aliases": [], "types": ["T044"], "canonical_name": "endotoxin receptor activity"}
{"concept_id": "C1749346", "aliases": [], "types": ["T043"], "canonical_name": "activation of TCC"}
{"concept_id": "C1749347", "aliases": [], "types": ["T043"], "canonical_name": "activation of the terminal complement cascade"}
{"concept_id": "C1749349", "aliases": [], "types": ["T043"], "canonical_name": "T cell mediated cytolysis"}
{"concept_id": "C1749350", "aliases": ["regulation of T-cell mediated cytolysis"], "types": ["T043"], "canonical_name": "regulation of T cell mediated cytolysis"}
{"concept_id": "C1749351", "aliases": ["negative regulation of T-cell mediated cytolysis"], "types": ["T043"], "canonical_name": "negative regulation of T cell mediated cytolysis"}
{"concept_id": "C1749352", "aliases": ["positive regulation of T-cell mediated cytolysis"], "types": ["T043"], "canonical_name": "positive regulation of T cell mediated cytolysis"}
{"concept_id": "C1749358", "aliases": [], "types": ["T038"], "canonical_name": "baroreceptor feedback control of blood pressure"}
{"concept_id": "C1749360", "aliases": [], "types": ["T040"], "canonical_name": "chemoreceptor control of blood pressure"}
{"concept_id": "C1749362", "aliases": [], "types": ["T040"], "canonical_name": "ischemic control of blood pressure"}
{"concept_id": "C1749375", "aliases": ["transforming growth factor beta ligand binding to type II receptor"], "types": ["T044"], "canonical_name": "transforming growth factor beta ligand binding to type II receptor", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1749376", "aliases": [], "types": ["T044"], "canonical_name": "leader sequence binding"}
{"concept_id": "C1749377", "aliases": [], "types": ["T044"], "canonical_name": "protein signal sequence binding"}
{"concept_id": "C1749378", "aliases": [], "types": ["T044"], "canonical_name": "signal sequence receptor"}
{"concept_id": "C1749384", "aliases": ["fibroblast growth factor receptor ligand"], "types": ["T044"], "canonical_name": "FGFR ligand"}
{"concept_id": "C1749385", "aliases": ["fz ligand"], "types": ["T044"], "canonical_name": "frizzled ligand"}
{"concept_id": "C1749387", "aliases": ["FGFR2 binding", "heartless binding"], "types": ["T044"], "canonical_name": "type 2 fibroblast growth factor receptor binding", "definition": "Binding to a type 2 fibroblast growth factor receptor (FGFR2). [GOC:fb_curators]"}
{"concept_id": "C1749388", "aliases": ["Notch ligand"], "types": ["T044"], "canonical_name": "N ligand"}
{"concept_id": "C1749389", "aliases": ["ptc ligand"], "types": ["T044"], "canonical_name": "patched ligand"}
{"concept_id": "C1749390", "aliases": [], "types": ["T044"], "canonical_name": "punt binding"}
{"concept_id": "C1749391", "aliases": ["saxophone binding"], "types": ["T044"], "canonical_name": "sax binding"}
{"concept_id": "C1749392", "aliases": [], "types": ["T044"], "canonical_name": "SE20 receptor binding"}
{"concept_id": "C1749393", "aliases": ["wishful thinking ligand"], "types": ["T044"], "canonical_name": "Wit ligand"}
{"concept_id": "C1749394", "aliases": ["sev binding"], "types": ["T044"], "canonical_name": "sevenless binding", "definition": "Binding to a sevenless (sev) protein, a receptor tyrosine kinase. [GOC:ceb, PMID:3151175]"}
{"concept_id": "C1749396", "aliases": [], "types": ["T044"], "canonical_name": "Toll ligand"}
{"concept_id": "C1749397", "aliases": ["torso ligand"], "types": ["T044"], "canonical_name": "tor ligand"}
{"concept_id": "C1749399", "aliases": [], "types": ["T044"], "canonical_name": "scavenger receptor binding", "definition": "Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. [GOC:ceb]"}
{"concept_id": "C1749400", "aliases": [], "types": ["T044"], "canonical_name": "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand"}
{"concept_id": "C1749401", "aliases": [], "types": ["T044"], "canonical_name": "ciliary neurotrophic factor receptor ligand"}
{"concept_id": "C1749404", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-3 receptor ligand"}
{"concept_id": "C1749405", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-5 receptor ligand"}
{"concept_id": "C1749406", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-6 receptor ligand"}
{"concept_id": "C1749407", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-7 receptor ligand"}
{"concept_id": "C1749408", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-10 receptor ligand"}
{"concept_id": "C1749409", "aliases": ["EGF receptor ligand"], "types": ["T044"], "canonical_name": "epidermal growth factor receptor ligand"}
{"concept_id": "C1749411", "aliases": [], "types": ["T044"], "canonical_name": "transforming growth factor alpha receptor ligand"}
{"concept_id": "C1749412", "aliases": ["M-CSF receptor binding", "macrophage colony stimulating factor receptor binding"], "types": ["T044"], "canonical_name": "macrophage colony-stimulating factor receptor binding", "definition": "Binding to a macrophage colony-stimulating factor receptor. [GOC:ai]"}
{"concept_id": "C1749413", "aliases": [], "types": ["T044"], "canonical_name": "insulin receptor ligand"}
{"concept_id": "C1749414", "aliases": [], "types": ["T044"], "canonical_name": "insulin-like growth factor receptor ligand"}
{"concept_id": "C1749415", "aliases": [], "types": ["T044"], "canonical_name": "nerve growth factor receptor ligand"}
{"concept_id": "C1749416", "aliases": [], "types": ["T044"], "canonical_name": "tumor necrosis factor receptor ligand"}
{"concept_id": "C1749417", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin p75 receptor ligand"}
{"concept_id": "C1749418", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin TRK receptor binding", "definition": "Binding to a neurotrophin TRK receptor. [GOC:ai]"}
{"concept_id": "C1749419", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin TRKA receptor ligand"}
{"concept_id": "C1749420", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin TRKB receptor binding", "definition": "Binding to a neurotrophin TRKB receptor. [GOC:ai]"}
{"concept_id": "C1749421", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin TRKC receptor binding", "definition": "Binding to a neurotrophin TRKC receptor. [GOC:ai]"}
{"concept_id": "C1749422", "aliases": [], "types": ["T044"], "canonical_name": "hepatocyte growth factor"}
{"concept_id": "C1749423", "aliases": [], "types": ["T044"], "canonical_name": "hepatocyte growth factor receptor ligand"}
{"concept_id": "C1749424", "aliases": [], "types": ["T044"], "canonical_name": "vascular endothelial growth factor receptor ligand"}
{"concept_id": "C1749425", "aliases": ["stem cell factor", "SCF"], "types": ["T044"], "canonical_name": "KIT binding"}
{"concept_id": "C1749426", "aliases": [], "types": ["T044"], "canonical_name": "stem cell factor receptor ligand"}
{"concept_id": "C1749427", "aliases": ["Neu receptor binding", "HER2 receptor binding"], "types": ["T044"], "canonical_name": "ErbB-2 class receptor binding", "definition": "Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2. [GOC:jl]"}
{"concept_id": "C1749428", "aliases": [], "types": ["T044"], "canonical_name": "integrin ligand"}
{"concept_id": "C1749430", "aliases": [], "types": ["T044"], "canonical_name": "volume-regulated channel"}
{"concept_id": "C1749431", "aliases": [], "types": ["T044"], "canonical_name": "intracellular calcium-activated potassium channel"}
{"concept_id": "C1749432", "aliases": [], "types": ["T044"], "canonical_name": "polycystin"}
{"concept_id": "C1749433", "aliases": [], "types": ["T044"], "canonical_name": "intercellular channel"}
{"concept_id": "C1749434", "aliases": [], "types": ["T044"], "canonical_name": "allantoin/allantoate transporter"}
{"concept_id": "C1749438", "aliases": [], "types": ["T044"], "canonical_name": "sodium/chloride-dependent creatine transporter"}
{"concept_id": "C1749440", "aliases": [], "types": ["T044"], "canonical_name": "sodium/phosphate cotransporter activity"}
{"concept_id": "C1749443", "aliases": [], "types": ["T044"], "canonical_name": "sodium/chloride-dependent organic acid cotransporter activity"}
{"concept_id": "C1749448", "aliases": ["myo-inositol:hydrogen symporter activity", "hydrogen/myo-inositol transporter activity"], "types": ["T044"], "canonical_name": "myo-inositol:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in). [TC:2.A.1.1.8]"}
{"concept_id": "C1749451", "aliases": [], "types": ["T044"], "canonical_name": "calcium pump"}
{"concept_id": "C1749452", "aliases": [], "types": ["T044"], "canonical_name": "sodium pump"}
{"concept_id": "C1749455", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen/oligopeptide symporter"}
{"concept_id": "C1749457", "aliases": [], "types": ["T044"], "canonical_name": "ligand"}
{"concept_id": "C1749469", "aliases": [], "types": ["T026"], "canonical_name": "inner envelope"}
{"concept_id": "C1749471", "aliases": [], "types": ["T026"], "canonical_name": "nuclear membrane lumen"}
{"concept_id": "C1749472", "aliases": [], "types": ["T026"], "canonical_name": "replication focus"}
{"concept_id": "C1749475", "aliases": [], "types": ["T026"], "canonical_name": "intra-peroxisomal peripheral membrane"}
{"concept_id": "C1749476", "aliases": ["translocon complex location", "Sec complex-associated translocon complex location", "translocon complex"], "types": ["T026"], "definition": "A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins. [GOC:mah, PMID:10611978, PMID:18166647, PMID:8612571]", "canonical_name": "Sec complex-associated translocon complex"}
{"concept_id": "C1749477", "aliases": [], "types": ["T026"], "canonical_name": "Golgi ribbon"}
{"concept_id": "C1749478", "aliases": [], "types": ["T026"], "canonical_name": "maturing face"}
{"concept_id": "C1749482", "aliases": [], "types": ["T026"], "canonical_name": "80S ribosome"}
{"concept_id": "C1749483", "aliases": ["20S core complex location"], "types": ["T026"], "canonical_name": "20S core complex"}
{"concept_id": "C1749486", "aliases": [], "types": ["T026"], "canonical_name": "bacterial inner membrane"}
{"concept_id": "C1749487", "aliases": [], "types": ["T026"], "canonical_name": "nicotinic acetylcholine receptor"}
{"concept_id": "C1749488", "aliases": [], "types": ["T026"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]", "canonical_name": "clathrin adaptor"}
{"concept_id": "C1749490", "aliases": [], "types": ["T026"], "canonical_name": "pleated desmosome"}
{"concept_id": "C1749493", "aliases": ["calcineurin complex location", "protein phosphatase type 2B complex location", "protein phosphatase type 2B complex"], "types": ["T026"], "canonical_name": "calcineurin complex", "definition": "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin. [PMID:26794871]"}
{"concept_id": "C1749495", "aliases": ["inositol metabolic process", "vitamin Bh metabolic process", "myo-inositol metabolic process", "vitamin Bh metabolism", "myo-inositol metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. [ISBN:0198547684]", "canonical_name": "inositol metabolism"}
{"concept_id": "C1749496", "aliases": [], "types": ["T044"], "canonical_name": "energy pathways"}
{"concept_id": "C1749497", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gluconeogenesis", "definition": "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. [GOC:go_curators]"}
{"concept_id": "C1749499", "aliases": [], "types": ["T044"], "canonical_name": "complex I (NADH to ubiquinone)"}
{"concept_id": "C1749500", "aliases": [], "types": ["T044"], "canonical_name": "complex III (ubiquinone to cytochrome c)"}
{"concept_id": "C1749501", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial electron transport, cytochrome c to oxygen", "definition": "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. [ISBN:0716731363]"}
{"concept_id": "C1749503", "aliases": [], "types": ["T044"], "canonical_name": "'de novo' purine biosynthesis"}
{"concept_id": "C1749509", "aliases": [], "types": ["T045"], "canonical_name": "DNA underwinding"}
{"concept_id": "C1749515", "aliases": ["endonucleolytic DNA catabolic process involved in apoptosis", "DNA catabolic process during apoptosis", "DNA catabolism during apoptosis", "DNA fragmentation involved in apoptotic nuclear change"], "types": ["T045"], "canonical_name": "apoptotic DNA fragmentation", "definition": "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]"}
{"concept_id": "C1749521", "aliases": [], "types": ["T045"], "canonical_name": "splicing GT-AG intron"}
{"concept_id": "C1749522", "aliases": [], "types": ["T045"], "canonical_name": "nuclear mRNA splicing via U12-type spliceosome"}
{"concept_id": "C1749524", "aliases": [], "types": ["T045"], "canonical_name": "mRNA processing", "definition": "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. [GOC:mah]"}
{"concept_id": "C1749525", "aliases": [], "types": ["T045"], "canonical_name": "protein synthesis elongation"}
{"concept_id": "C1749526", "aliases": [], "types": ["T045"], "canonical_name": "protein synthesis termination"}
{"concept_id": "C1749527", "aliases": [], "types": ["T045"], "canonical_name": "translational readthrough", "definition": "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons. [GOC:jsg, PMID:11179232]"}
{"concept_id": "C1749531", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine catabolism"}
{"concept_id": "C1749534", "aliases": [], "types": ["T044"], "canonical_name": "indolamine metabolism"}
{"concept_id": "C1749537", "aliases": [], "types": ["T044"], "canonical_name": "aromatic hydrocarbon metabolism"}
{"concept_id": "C1749546", "aliases": [], "types": ["T044"], "canonical_name": "niacin metabolism"}
{"concept_id": "C1749548", "aliases": [], "types": ["T044"], "canonical_name": "vitamin B3 metabolism"}
{"concept_id": "C1749549", "aliases": [], "types": ["T043"], "canonical_name": "potassium conductance"}
{"concept_id": "C1749550", "aliases": ["K+ conductance"], "types": ["T044"], "canonical_name": "potassium ion conductance"}
{"concept_id": "C1749551", "aliases": [], "types": ["T043"], "canonical_name": "sodium:solute transport"}
{"concept_id": "C1749552", "aliases": [], "types": ["T043"], "canonical_name": "sodium:dicarboxylate transport"}
{"concept_id": "C1749553", "aliases": [], "types": ["T043"], "canonical_name": "sodium:neurotransmitter transport"}
{"concept_id": "C1749556", "aliases": [], "types": ["T043"], "canonical_name": "nonselective vesicle endocytosis"}
{"concept_id": "C1749557", "aliases": ["vesicle biosynthesis", "membrane evagination", "vesicle formation"], "types": ["T043"], "definition": "The evagination of a membrane, resulting in formation of a vesicle. [GOC:jid, GOC:tb]", "canonical_name": "vesicle budding from membrane"}
{"concept_id": "C1749558", "aliases": [], "types": ["T043"], "canonical_name": "vesicle coating", "definition": "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. [GOC:jid]"}
{"concept_id": "C1749562", "aliases": [], "types": ["T043"], "canonical_name": "viral-induced membrane fusion"}
{"concept_id": "C1749564", "aliases": ["unfolded protein response, up-regulation of target gene transcription", "unfolded protein response, upregulation of target gene transcription", "positive regulation of transcription of target genes involved in unfolded protein response", "unfolded protein response, positive regulation of target gene transcription", "unfolded protein response, up regulation of target gene transcription"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response", "definition": "The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response. [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763]"}
{"concept_id": "C1749565", "aliases": [], "types": ["T043"], "canonical_name": "nuclear morphology"}
{"concept_id": "C1749567", "aliases": [], "types": ["T043"], "canonical_name": "mitotic chromosome movement"}
{"concept_id": "C1749569", "aliases": ["site selection involved in cell cycle cytokinesis", "site selection involved in cytokinesis"], "types": ["T043"], "canonical_name": "cytokinesis, site selection", "definition": "The process of marking the place where cytokinesis will occur. [GOC:mtg_cell_cycle]"}
{"concept_id": "C1749571", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell budding", "definition": "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds. [GOC:mah]"}
{"concept_id": "C1749572", "aliases": [], "types": ["T043"], "canonical_name": "bud growth"}
{"concept_id": "C1749573", "aliases": [], "types": ["T043"], "canonical_name": "budding cell apical bud growth", "definition": "Growth at the tip of a bud, in a cell that reproduces by budding. [GOC:go_curators]"}
{"concept_id": "C1749574", "aliases": [], "types": ["T043"], "canonical_name": "isotropic bud growth"}
{"concept_id": "C1749575", "aliases": [], "types": ["T043"], "canonical_name": "axial budding"}
{"concept_id": "C1749576", "aliases": [], "types": ["T043"], "canonical_name": "bipolar budding"}
{"concept_id": "C1749577", "aliases": [], "types": ["T043"], "canonical_name": "polar budding"}
{"concept_id": "C1749578", "aliases": [], "types": ["T043"], "canonical_name": "female meiotic recombination"}
{"concept_id": "C1749579", "aliases": [], "types": ["T044"], "canonical_name": "Hedgehog protein processing"}
{"concept_id": "C1749580", "aliases": [], "types": ["T038"], "canonical_name": "hormonal control of blood pressure"}
{"concept_id": "C1749581", "aliases": ["circulatory renin-angiotensin regulation of blood pressure", "circulatory renin-angiotensin blood pressure regulation"], "types": ["T038"], "canonical_name": "regulation of systemic arterial blood pressure by circulatory renin-angiotensin", "definition": "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. [ISBN:0721643949]"}
{"concept_id": "C1749582", "aliases": ["blood pressure regulation by vasopressin"], "types": ["T039"], "canonical_name": "regulation of systemic arterial blood pressure by vasopressin", "definition": "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport. [GOC:mtg_cardio, ISBN:0721643949]"}
{"concept_id": "C1749583", "aliases": ["norepinephrine-epinephrine blood pressure regulation"], "types": ["T039"], "canonical_name": "regulation of systemic arterial blood pressure by norepinephrine-epinephrine", "definition": "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system. [ISBN:0721643949]"}
{"concept_id": "C1749584", "aliases": ["norepinephrine-epinephrine vasoconstriction during control of blood pressure"], "types": ["T044"], "canonical_name": "norepinephrine-epinephrine vasoconstriction during blood pressure control"}
{"concept_id": "C1749587", "aliases": [], "types": ["T038"], "canonical_name": "increased chronotropy by epinephrine-norepinephrine"}
{"concept_id": "C1749588", "aliases": [], "types": ["T038"], "canonical_name": "positive control of heart contraction rate by epinephrine-norepinephrine"}
{"concept_id": "C1749590", "aliases": ["angiotensin mediated vasoconstriction during control of blood pressure"], "types": ["T038"], "canonical_name": "angiotensin mediated vasoconstriction during blood pressure control"}
{"concept_id": "C1749591", "aliases": [], "types": ["T038"], "canonical_name": "renal response to blood flow during renin-angiotensin control of blood pressure"}
{"concept_id": "C1749592", "aliases": ["control of blood angiotensin level"], "types": ["T040"], "canonical_name": "control of angiotensin levels in blood"}
{"concept_id": "C1749596", "aliases": [], "types": ["T038"], "canonical_name": "renin-angiotensin control of body fluid levels"}
{"concept_id": "C1749598", "aliases": [], "types": ["T039"], "canonical_name": "renin-angiotensin control of aldosterone production"}
{"concept_id": "C1749599", "aliases": ["angiotensin-mediated regulation of renal output", "angiotensin mediated regulation of renal output"], "types": ["T038"], "canonical_name": "regulation of renal output by angiotensin", "definition": "The process in which angiotensin directly modulates the rate of urine output by the kidney. [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]"}
{"concept_id": "C1749719", "aliases": ["acquired immune response", "adaptive immune response"], "types": ["T040"], "definition": "An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]", "canonical_name": "immune memory response"}
{"concept_id": "C1749769", "aliases": ["border cell migration"], "types": ["T043"], "canonical_name": "border follicle cell migration", "definition": "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:10822261]"}
{"concept_id": "C1749775", "aliases": [], "types": ["T043"], "canonical_name": "fusion of sperm to egg plasma membrane involved in single fertilization", "definition": "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head. [GOC:dph, GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]"}
{"concept_id": "C1749776", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cell cycle regulator"}
{"concept_id": "C1749777", "aliases": [], "types": ["T043"], "canonical_name": "preblastoderm mitotic cell cycle regulator"}
{"concept_id": "C1749784", "aliases": [], "types": ["T042"], "canonical_name": "axon growth"}
{"concept_id": "C1749786", "aliases": [], "types": ["T042"], "canonical_name": "defasciculation of neuron"}
{"concept_id": "C1749797", "aliases": ["heart formation", "cardiogenesis"], "types": ["T042"], "definition": "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]", "canonical_name": "heart development"}
{"concept_id": "C1749800", "aliases": [], "types": ["T045"], "canonical_name": "mating type switching", "definition": "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus. [PMID:9928492]"}
{"concept_id": "C1749801", "aliases": [], "types": ["T043"], "canonical_name": "donor preference"}
{"concept_id": "C1749802", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cuticle hardening"}
{"concept_id": "C1749803", "aliases": [], "types": ["T043"], "canonical_name": "nutritional response pathway"}
{"concept_id": "C1749809", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP8A1"}
{"concept_id": "C1749810", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP7A1"}
{"concept_id": "C1749812", "aliases": ["COP9 complex", "CSN", "COP9 complex location"], "types": ["T026"], "canonical_name": "COP9 signalosome", "definition": "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. [PMID:11019806, PMID:12186635, PMID:14570571]"}
{"concept_id": "C1749813", "aliases": [], "types": ["T044"], "canonical_name": "potassium-dependent sodium/calcium exchanger"}
{"concept_id": "C1749814", "aliases": [], "types": ["T026"], "canonical_name": "9S cohesin"}
{"concept_id": "C1749815", "aliases": ["Smc1-Smc3 complex location"], "types": ["T026"], "canonical_name": "Smc1-Smc3 complex"}
{"concept_id": "C1749816", "aliases": ["mRNA positioning, intracellular"], "types": ["T043"], "canonical_name": "intracellular mRNA positioning"}
{"concept_id": "C1749817", "aliases": [], "types": ["T044"], "canonical_name": "gurken receptor ligand"}
{"concept_id": "C1749820", "aliases": [], "types": ["T043"], "canonical_name": "primordial germ cell migration"}
{"concept_id": "C1749821", "aliases": ["asymmetrical cytokinesis"], "types": ["T043"], "canonical_name": "asymmetric cytokinesis"}
{"concept_id": "C1749825", "aliases": [], "types": ["T044"], "canonical_name": "steroid 7-alpha-hydroxylase activity", "definition": "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O. [GOC:mah]"}
{"concept_id": "C1749827", "aliases": [], "types": ["T044"], "canonical_name": "testosterone 16-alpha-hydroxylase activity", "definition": "Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O. [GOC:ai]"}
{"concept_id": "C1749829", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2J5"}
{"concept_id": "C1749830", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2J6"}
{"concept_id": "C1749833", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP51"}
{"concept_id": "C1749834", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP261"}
{"concept_id": "C1749836", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2C29"}
{"concept_id": "C1749837", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2C39"}
{"concept_id": "C1749838", "aliases": [], "types": ["T044"], "canonical_name": "arachidonic acid 11,12-epoxygenase activity", "definition": "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, RHEA:51480]"}
{"concept_id": "C1749844", "aliases": [], "types": ["T044"], "canonical_name": "reduced folate transporter"}
{"concept_id": "C1749845", "aliases": [], "types": ["T044"], "canonical_name": "L-ascorbate:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in). [GOC:mah, GOC:yaf, PMID:18094143]"}
{"concept_id": "C1749846", "aliases": ["deoxyribonucleate glycosidase activity", "Fapy-DNA glycosylase activity", "DNA-formamidopyrimidine glycosylase activity", "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity", "formamidopyrimidine-DNA glycosylase activity", "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity", "oxidized purine base lesion DNA N-glycosylase activity"], "types": ["T045"], "canonical_name": "oxidized purine nucleobase lesion DNA N-glycosylase activity", "definition": "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. [GOC:elh, PMID:11554296]"}
{"concept_id": "C1749847", "aliases": ["cytochrome c oxidase complex assembly"], "types": ["T044"], "canonical_name": "respiratory chain complex IV assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]"}
{"concept_id": "C1749862", "aliases": ["microtubule anchoring at kinetochore", "attachment of spindle microtubules to chromosome", "spindle kinetochore attachment", "spindle chromosome attachment", "kinetochore-microtubule attachment"], "types": ["T045"], "canonical_name": "attachment of spindle microtubules to kinetochore", "definition": "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. [GOC:vw, PMID:10322137]"}
{"concept_id": "C1749863", "aliases": ["ISW2 complex location"], "types": ["T026"], "canonical_name": "ISW2 complex"}
{"concept_id": "C1749865", "aliases": [], "types": ["T043"], "canonical_name": "carbohydrate transport", "definition": "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. [GOC:ai]"}
{"concept_id": "C1749868", "aliases": [], "types": ["T044"], "canonical_name": "Holliday junction resolvase activity"}
{"concept_id": "C1749870", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine biosynthesis"}
{"concept_id": "C1749873", "aliases": [], "types": ["T044"], "canonical_name": "siderochrome metabolism"}
{"concept_id": "C1749876", "aliases": [], "types": ["T026"], "canonical_name": "30S ribosomal subunit"}
{"concept_id": "C1749877", "aliases": [], "types": ["T026"], "canonical_name": "prokaryotic small ribosomal subunit"}
{"concept_id": "C1749878", "aliases": ["cellular DNA import during transformation", "DNA transport into cell during transformation"], "types": ["T043"], "canonical_name": "DNA import into cell involved in transformation", "definition": "The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell. [GOC:ai]"}
{"concept_id": "C1749881", "aliases": [], "types": ["T045"], "canonical_name": "genetic exchange"}
{"concept_id": "C1749882", "aliases": ["fimbriae assembly"], "types": ["T043"], "canonical_name": "fimbria assembly"}
{"concept_id": "C1749883", "aliases": ["fimbria biogenesis"], "types": ["T043"], "canonical_name": "fimbriae biogenesis"}
{"concept_id": "C1749884", "aliases": ["fimbrium assembly"], "types": ["T043"], "canonical_name": "fimbrial assembly"}
{"concept_id": "C1749885", "aliases": [], "types": ["T043"], "canonical_name": "fimbrium biogenesis"}
{"concept_id": "C1749889", "aliases": [], "types": ["T045"], "canonical_name": "DNA restriction"}
{"concept_id": "C1749890", "aliases": [], "types": ["T044"], "canonical_name": "PTS system"}
{"concept_id": "C1749891", "aliases": [], "types": ["T039"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:lr]", "canonical_name": "response to heat"}
{"concept_id": "C1749892", "aliases": [], "types": ["T044"], "canonical_name": "methylglyoxal bypass"}
{"concept_id": "C1749893", "aliases": [], "types": ["T044"], "canonical_name": "methylglyoxal pathway"}
{"concept_id": "C1749894", "aliases": [], "types": ["T044"], "canonical_name": "allantoin degradation pathway"}
{"concept_id": "C1749896", "aliases": [], "types": ["T040"], "canonical_name": "skotomorphogenesis", "definition": "The control of plant growth, development, and differentiation in response to growth in darkness. [http://www.plantphys.net/article.php?ch=t&id=63, PMID:15012288]"}
{"concept_id": "C1749899", "aliases": [], "types": ["T044"], "canonical_name": "high affinity potassium transporter"}
{"concept_id": "C1749901", "aliases": [], "types": ["T044"], "canonical_name": "energy dissipation"}
{"concept_id": "C1749903", "aliases": ["ethylene-forming enzyme"], "types": ["T044"], "canonical_name": "ethene-forming enzyme"}
{"concept_id": "C1749904", "aliases": [], "types": ["T043"], "canonical_name": "cell elongation"}
{"concept_id": "C1749906", "aliases": [], "types": ["T043"], "canonical_name": "high-fluence-rate response"}
{"concept_id": "C1749907", "aliases": [], "types": ["T043"], "canonical_name": "low-fluence-rate response"}
{"concept_id": "C1749909", "aliases": [], "types": ["T042"], "canonical_name": "anterior/posterior pattern specification", "definition": "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]"}
{"concept_id": "C1749910", "aliases": [], "types": ["T042"], "canonical_name": "proximal/distal pattern specification"}
{"concept_id": "C1749911", "aliases": [], "types": ["T043"], "canonical_name": "adaxial/abaxial pattern specification", "definition": "The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure. [GOC:dph, GOC:isa_complete, GOC:tb]"}
{"concept_id": "C1749912", "aliases": [], "types": ["T042"], "canonical_name": "radial pattern formation", "definition": "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur. [GOC:dph, GOC:go_curators, GOC:isa_complete]"}
{"concept_id": "C1749913", "aliases": [], "types": ["T039"], "canonical_name": "root gravitropism"}
{"concept_id": "C1749914", "aliases": [], "types": ["T039"], "canonical_name": "negative gravitropism", "definition": "The orientation of plant parts away from gravity. [GOC:sm]"}
{"concept_id": "C1749916", "aliases": [], "types": ["T043"], "canonical_name": "cardiomyocyte generation"}
{"concept_id": "C1749917", "aliases": [], "types": ["T044"], "canonical_name": "auxin receptor"}
{"concept_id": "C1749918", "aliases": [], "types": ["T043"], "canonical_name": "zygote asymmetric cell division", "definition": "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. [GOC:tb]"}
{"concept_id": "C1749920", "aliases": [], "types": ["T044"], "canonical_name": "mycothiol-dependent detoxification", "definition": "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell. [GOC:pz]"}
{"concept_id": "C1749922", "aliases": [], "types": ["T044"], "canonical_name": "alpha-tocopherol biosynthesis"}
{"concept_id": "C1749926", "aliases": [], "types": ["T038"], "canonical_name": "phosphate ion perception"}
{"concept_id": "C1749927", "aliases": [], "types": ["T038"], "canonical_name": "phosphate ion sensing"}
{"concept_id": "C1750079", "aliases": ["[heparan sulphate]-glucosamine N-sulphotransferase activity", "N-heparan sulfate sulfotransferase activity", "N-desulfoheparin sulfotransferase activity", "heparan sulfate N-sulfotransferase activity", "heparin-glucosamine N-sulfotransferase activity", "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity", "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity", "heparitin N-sulfotransferase activity", "heparitin sulfotransferase activity", "heparan sulfate N-deacetylase/N-sulfotransferase activity", "N-HSST activity", "PAPS:N-desulfoheparin sulfotransferase activity", "heparan sulfate 2-N-sulfotransferase activity", "heparin N-sulfotransferase activity", "PAPS:DSH sulfotransferase activity", "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity", "heparitin N-sulphotransferase activity", "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity", "desulfoheparin sulfotransferase activity", "glucosaminyl N-deacetylase/N-sulfotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine. [EC:2.8.2.8]", "canonical_name": "[heparan sulfate]-glucosamine N-sulfotransferase activity"}
{"concept_id": "C1750080", "aliases": [], "types": ["T043"], "canonical_name": "enzyme transport"}
{"concept_id": "C1750185", "aliases": [], "types": ["T044"], "canonical_name": "ligand-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C1750187", "aliases": [], "types": ["T044"], "canonical_name": "innexin"}
{"concept_id": "C1750188", "aliases": [], "types": ["T044"], "canonical_name": "sialate transporter activity"}
{"concept_id": "C1750189", "aliases": [], "types": ["T044"], "canonical_name": "siderochrome-iron transporter activity"}
{"concept_id": "C1750190", "aliases": [], "types": ["T044"], "canonical_name": "siderochrome-iron (ferrioxamine) uptake transporter"}
{"concept_id": "C1750191", "aliases": [], "types": ["T044"], "canonical_name": "bilitranslocase"}
{"concept_id": "C1750193", "aliases": ["sodium:hydrogen exchanger", "pH-dependent sodium:proton antiporter activity", "sodium:hydrogen antiporter activity", "sodium:hydrogen exchange activity", "sodium/hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "sodium:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). [TC:2.A.35.1.1, TC:2.A.36.-.-]"}
{"concept_id": "C1750196", "aliases": [], "types": ["T044"], "canonical_name": "conjugate transporter activity"}
{"concept_id": "C1750204", "aliases": [], "types": ["T044"], "canonical_name": "D-ribose porter activity"}
{"concept_id": "C1750205", "aliases": [], "types": ["T044"], "canonical_name": "D-xylose porter activity"}
{"concept_id": "C1750226", "aliases": [], "types": ["T043"], "canonical_name": "amine/polyamine transport"}
{"concept_id": "C1750227", "aliases": [], "types": ["T043"], "canonical_name": "siderochrome transport"}
{"concept_id": "C1750228", "aliases": [], "types": ["T043"], "canonical_name": "iron-siderochrome transport"}
{"concept_id": "C1750246", "aliases": [], "types": ["T044"], "canonical_name": "thyroid NADPH oxidase activity"}
{"concept_id": "C1750248", "aliases": [], "types": ["T044"], "canonical_name": "neutrophil cytosol factor 2"}
{"concept_id": "C1750249", "aliases": ["malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O. [EC:2.3.1.170]", "canonical_name": "6'-deoxychalcone synthase activity"}
{"concept_id": "C1750252", "aliases": ["GIM complex location"], "types": ["T026"], "canonical_name": "GIM complex"}
{"concept_id": "C1750253", "aliases": [], "types": ["T043"], "canonical_name": "meiotic chromosome movement"}
{"concept_id": "C1750254", "aliases": [], "types": ["T043"], "canonical_name": "female meiotic chromosome movement"}
{"concept_id": "C1750255", "aliases": [], "types": ["T043"], "canonical_name": "male meiotic chromosome movement"}
{"concept_id": "C1750262", "aliases": [], "types": ["T026"], "canonical_name": "trifunctional enzyme"}
{"concept_id": "C1750265", "aliases": [], "types": ["T043"], "canonical_name": "peroxisome receptor docking"}
{"concept_id": "C1750266", "aliases": [], "types": ["T043"], "canonical_name": "peroxisome receptor translocation"}
{"concept_id": "C1750267", "aliases": [], "types": ["T043"], "canonical_name": "peroxisome receptor recycling"}
{"concept_id": "C1750268", "aliases": [], "types": ["T043"], "canonical_name": "PTS receptor recycling"}
{"concept_id": "C1750269", "aliases": [], "types": ["T026"], "canonical_name": "nuclear dot"}
{"concept_id": "C1750270", "aliases": ["splicing speckle", "nuclear speckles", "nuclear speck"], "types": ["T026"], "definition": "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]", "canonical_name": "nuclear speckle"}
{"concept_id": "C1750276", "aliases": ["sirohydrochlorin cobaltochelatase activity", "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)", "sirohydrochlorin cobalt-lyase activity", "cobaltochelatase"], "types": ["T044"], "definition": "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+. [RHEA:15893]", "canonical_name": "anaerobic cobalt chelatase activity"}
{"concept_id": "C1750279", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome complex assembly", "definition": "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. [GOC:jl, GOC:mah]"}
{"concept_id": "C1750284", "aliases": [], "types": ["T044"], "canonical_name": "sulfonylurea receptor ligand"}
{"concept_id": "C1750285", "aliases": [], "types": ["T044"], "canonical_name": "deoxycytidyl transferase activity", "definition": "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA. [PMID:10535901]"}
{"concept_id": "C1750288", "aliases": [], "types": ["T026"], "canonical_name": "peptide chain release factor"}
{"concept_id": "C1750293", "aliases": ["viral envelope fusion"], "types": ["T043"], "canonical_name": "viral envelope fusion"}
{"concept_id": "C1750294", "aliases": [], "types": ["T043"], "canonical_name": "virus particle maturation"}
{"concept_id": "C1750296", "aliases": ["immediate early viral mRNA transcription"], "types": ["T045"], "canonical_name": "early viral transcription", "definition": "The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell. [GOC:bf, GOC:jh2, GOC:jl]"}
{"concept_id": "C1750465", "aliases": [], "types": ["T044"], "canonical_name": "siderochrome biosynthesis"}
{"concept_id": "C1750467", "aliases": ["anaerobic respiration, using ammonium as electron donor"], "types": ["T038"], "definition": "The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2. [MetaCyc:P303-PWY]", "canonical_name": "anammox"}
{"concept_id": "C1750468", "aliases": [], "types": ["T040"], "canonical_name": "aerobic respiration, using nitrite as electron donor", "definition": "The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species. [MetaCyc:P282-PWY]"}
{"concept_id": "C1750469", "aliases": [], "types": ["T044"], "canonical_name": "homocysteine-cysteine interconversion"}
{"concept_id": "C1750470", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen oxidation"}
{"concept_id": "C1750471", "aliases": [], "types": ["T044"], "canonical_name": "acetate utilization"}
{"concept_id": "C1750474", "aliases": [], "types": ["T044"], "canonical_name": "2,5-dihydroxypyridine utilization"}
{"concept_id": "C1750475", "aliases": [], "types": ["T044"], "canonical_name": "methionine recycling"}
{"concept_id": "C1750476", "aliases": [], "types": ["T044"], "canonical_name": "methionine regeneration"}
{"concept_id": "C1750482", "aliases": [], "types": ["T044"], "canonical_name": "L-arabitol utilization"}
{"concept_id": "C1750483", "aliases": [], "types": ["T044"], "canonical_name": "ribulose monophosphate cycle"}
{"concept_id": "C1750484", "aliases": [], "types": ["T044"], "canonical_name": "Stickland reaction"}
{"concept_id": "C1750485", "aliases": ["L-arabitol and xylitol degradation"], "types": ["T044"], "canonical_name": "L-arabitol and xylitol degradation"}
{"concept_id": "C1750486", "aliases": [], "types": ["T044"], "canonical_name": "L-xylitol utilization"}
{"concept_id": "C1750489", "aliases": ["peroxisome vesicle"], "types": ["T026"], "canonical_name": "peroxisome vesicle"}
{"concept_id": "C1751127", "aliases": [], "types": ["T043"], "canonical_name": "actin filament-based process", "definition": "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. [GOC:mah]"}
{"concept_id": "C1751128", "aliases": [], "types": ["T043"], "canonical_name": "cell surface structure organization and biogenesis"}
{"concept_id": "C1751129", "aliases": [], "types": ["T044"], "canonical_name": "glial cell line-derived neurotrophic factor receptor binding"}
{"concept_id": "C1751130", "aliases": [], "types": ["T044"], "canonical_name": "benzodiazepine receptor ligand"}
{"concept_id": "C1751133", "aliases": [], "types": ["T044"], "canonical_name": "semaphorin receptor binding", "definition": "Binding to a semaphorin receptor. [GOC:ceb, PMID:12001990]"}
{"concept_id": "C1751136", "aliases": ["junctional membrane complex location"], "types": ["T026"], "canonical_name": "junctional membrane complex", "definition": "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules). [PMID:11535622]"}
{"concept_id": "C1751137", "aliases": [], "types": ["T043"], "canonical_name": "DNA damage response, signal transduction by p53 class mediator", "definition": "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:go_curators]"}
{"concept_id": "C1751138", "aliases": ["intercellular adhesion molecule-3 receptor ligand"], "types": ["T044"], "canonical_name": "ICAM-3 receptor ligand"}
{"concept_id": "C1751139", "aliases": ["high molecular weight B-lymphocyte growth factor receptor binding", "high molecular weight B-cell growth factor receptor binding", "high molecular weight B lymphocyte growth factor receptor binding"], "types": ["T044"], "canonical_name": "high molecular weight B cell growth factor receptor binding", "definition": "Binding to a high molecular weight B cell growth factor receptor. [GOC:ai]"}
{"concept_id": "C1751140", "aliases": ["heterochromatic silencing at silent mating-type cassette", "chromatin silencing at silent mating-type cassette", "silent mating-type cassette chromatin silencing"], "types": ["T045"], "canonical_name": "silent mating-type cassette heterochromatin assembly", "definition": "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin. [GOC:mcc]"}
{"concept_id": "C1751145", "aliases": [], "types": ["T043"], "canonical_name": "nuclear movement, microtubule-mediated"}
{"concept_id": "C1751148", "aliases": [], "types": ["T043"], "canonical_name": "ascospore wall assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae. [GOC:mcc, PMID:14702385]"}
{"concept_id": "C1751154", "aliases": [], "types": ["T026"], "canonical_name": "Golgi-associated vesicle membrane", "definition": "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. [GOC:mah]"}
{"concept_id": "C1751159", "aliases": [], "types": ["T044"], "canonical_name": "border cell delamination"}
{"concept_id": "C1751160", "aliases": [], "types": ["T038"], "canonical_name": "regulation of border follicle cell delamination", "definition": "Any process that regulates the frequency, rate or extent of border cell delamination. [PMID:10822261]"}
{"concept_id": "C1751161", "aliases": ["upregulation of border follicle cell delamination", "up regulation of border follicle cell delamination", "up-regulation of border follicle cell delamination"], "types": ["T044"], "canonical_name": "positive regulation of border follicle cell delamination", "definition": "Any process that increases the frequency, rate or extent of border cell delamination. [PMID:10822261]"}
{"concept_id": "C1751162", "aliases": ["down-regulation of border follicle cell delamination", "downregulation of border follicle cell delamination", "down regulation of border follicle cell delamination"], "types": ["T044"], "canonical_name": "negative regulation of border follicle cell delamination", "definition": "Any process that decreases the frequency, rate or extent of border cell delamination. [PMID:10822261]"}
{"concept_id": "C1751163", "aliases": [], "types": ["T042"], "canonical_name": "oocyte positioning during oogenesis"}
{"concept_id": "C1751164", "aliases": [], "types": ["T043"], "canonical_name": "primary septum hydrolysis"}
{"concept_id": "C1751165", "aliases": [], "types": ["T043"], "canonical_name": "septum edging hydrolysis"}
{"concept_id": "C1751168", "aliases": [], "types": ["T044"], "canonical_name": "beta-filamin binding"}
{"concept_id": "C1751173", "aliases": ["karyopherin docking complex location"], "types": ["T026"], "canonical_name": "karyopherin docking complex", "definition": "OBSOLETE. A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p. [PMID:11867631, PMID:9864357]"}
{"concept_id": "C1751174", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament assembly or disassembly"}
{"concept_id": "C1751175", "aliases": [], "types": ["T044"], "canonical_name": "myosin filament assembly", "definition": "The aggregation, arrangement and bonding together of a filament composed of myosin molecules. [GOC:mah]"}
{"concept_id": "C1751176", "aliases": [], "types": ["T044"], "canonical_name": "myosin filament disassembly", "definition": "The disassembly of a filament composed of myosin molecules. [GOC:mah]"}
{"concept_id": "C1751177", "aliases": [], "types": ["T043"], "canonical_name": "myosin II filament assembly", "definition": "The formation of a bipolar filament composed of myosin II molecules. [GOC:mah]"}
{"concept_id": "C1751178", "aliases": [], "types": ["T043"], "canonical_name": "myosin II filament disassembly", "definition": "The disassembly of a bipolar filament composed of myosin II molecules. [GOC:mah]"}
{"concept_id": "C1751179", "aliases": [], "types": ["T043"], "canonical_name": "myosin II filament assembly or disassembly"}
{"concept_id": "C1751180", "aliases": [], "types": ["T045"], "canonical_name": "RNA-mediated TGS"}
{"concept_id": "C1751191", "aliases": [], "types": ["T040"], "canonical_name": "maltose hydrolysis"}
{"concept_id": "C1751194", "aliases": ["signal transduction involved in DNA damage checkpoint", "DNA damage checkpoint"], "types": ["T045"], "canonical_name": "DNA damage checkpoint signaling", "definition": "A signal transduction process that contributes to a DNA damage checkpoint. [GOC:mah]"}
{"concept_id": "C1751367", "aliases": ["thyrotropin releasing hormone receptor binding"], "types": ["T044"], "canonical_name": "thyrotropin-releasing hormone receptor binding", "definition": "Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary. [PMID:8592728]"}
{"concept_id": "C1751368", "aliases": [], "types": ["T044"], "canonical_name": "brain-derived neurotrophic factor ligand"}
{"concept_id": "C1751372", "aliases": [], "types": ["T044"], "canonical_name": "adenosine receptor binding", "definition": "Binding to an adenosine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751373", "aliases": [], "types": ["T044"], "canonical_name": "A1 adenosine receptor ligand"}
{"concept_id": "C1751374", "aliases": [], "types": ["T044"], "canonical_name": "A2A adenosine receptor binding", "definition": "Binding to an A2A adenosine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751375", "aliases": [], "types": ["T044"], "canonical_name": "A2B adenosine receptor binding", "definition": "Binding to an A2B adenosine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751376", "aliases": [], "types": ["T044"], "canonical_name": "A3 adenosine receptor binding", "definition": "Binding to an A3 adenosine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751377", "aliases": [], "types": ["T044"], "canonical_name": "adrenergic receptor binding", "definition": "Binding to an adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751378", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1A adrenergic receptor binding", "definition": "Binding to an alpha-1A adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751379", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1B adrenergic receptor binding", "definition": "Binding to an alpha-1B adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751380", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1D adrenergic receptor ligand"}
{"concept_id": "C1751381", "aliases": [], "types": ["T044"], "canonical_name": "alpha-2A adrenergic receptor binding", "definition": "Binding to an alpha-2A adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751382", "aliases": [], "types": ["T044"], "canonical_name": "alpha-2B adrenergic receptor ligand"}
{"concept_id": "C1751383", "aliases": [], "types": ["T044"], "canonical_name": "alpha-2C adrenergic receptor binding", "definition": "Binding to an alpha-2C adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751384", "aliases": [], "types": ["T044"], "canonical_name": "beta-1 adrenergic receptor binding", "definition": "Binding to a beta-1 adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751385", "aliases": [], "types": ["T044"], "canonical_name": "beta-2 adrenergic receptor binding", "definition": "Binding to a beta-2 adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751386", "aliases": [], "types": ["T044"], "canonical_name": "beta-3 adrenergic receptor binding", "definition": "Binding to a beta-3 adrenergic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751387", "aliases": [], "types": ["T044"], "canonical_name": "adrenomedullin receptor ligand"}
{"concept_id": "C1751388", "aliases": [], "types": ["T044"], "canonical_name": "type 1 angiotensin receptor ligand"}
{"concept_id": "C1751389", "aliases": [], "types": ["T044"], "canonical_name": "type 2 angiotensin receptor ligand"}
{"concept_id": "C1751390", "aliases": [], "types": ["T044"], "canonical_name": "bombesin receptor binding", "definition": "Binding to a bombesin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751391", "aliases": [], "types": ["T044"], "canonical_name": "subtype 3 bombesin receptor binding", "definition": "Binding to a subtype 3 bombesin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751392", "aliases": [], "types": ["T044"], "canonical_name": "endothelin A receptor ligand"}
{"concept_id": "C1751393", "aliases": [], "types": ["T044"], "canonical_name": "endothelin B receptor ligand"}
{"concept_id": "C1751394", "aliases": ["gastrin-releasing peptide receptor ligand", "GRP receptor binding"], "types": ["T044"], "canonical_name": "gastrin-releasing peptide receptor binding", "definition": "Binding to a gastrin-releasing peptide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751395", "aliases": [], "types": ["T044"], "canonical_name": "neuromedin B receptor ligand"}
{"concept_id": "C1751396", "aliases": [], "types": ["T044"], "canonical_name": "bradykinin receptor ligand"}
{"concept_id": "C1751397", "aliases": [], "types": ["T044"], "canonical_name": "B1 bradykinin receptor binding", "definition": "Binding to a B1 bradykinin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751398", "aliases": [], "types": ["T044"], "canonical_name": "B2 bradykinin receptor ligand"}
{"concept_id": "C1751399", "aliases": [], "types": ["T044"], "canonical_name": "C5a anaphylatoxin chemotactic receptor binding", "definition": "Binding to a C5a anaphylatoxin chemotactic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751400", "aliases": [], "types": ["T044"], "canonical_name": "C5L2 anaphylatoxin chemotactic receptor binding", "definition": "Binding to a C5L2 anaphylatoxin chemotactic receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751401", "aliases": [], "types": ["T044"], "canonical_name": "calcitonin receptor ligand"}
{"concept_id": "C1751402", "aliases": [], "types": ["T044"], "canonical_name": "cannabinoid receptor binding", "definition": "Binding to a cannabinoid receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751403", "aliases": [], "types": ["T044"], "canonical_name": "type 1 cannabinoid receptor binding", "definition": "Binding to a type 1 cannabinoid receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751404", "aliases": [], "types": ["T044"], "canonical_name": "type 2 cannabinoid receptor binding", "definition": "Binding to a type 2 cannabinoid receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751405", "aliases": ["stromal cell-derived factor 1 receptor binding"], "types": ["T044"], "canonical_name": "CXCR4 chemokine receptor binding", "definition": "Binding to a CXCR4 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751406", "aliases": [], "types": ["T044"], "canonical_name": "CXCR5 chemokine receptor ligand"}
{"concept_id": "C1751407", "aliases": [], "types": ["T044"], "canonical_name": "CXCR6 chemokine receptor ligand"}
{"concept_id": "C1751408", "aliases": [], "types": ["T044"], "canonical_name": "CCR1 chemokine receptor ligand"}
{"concept_id": "C1751409", "aliases": [], "types": ["T044"], "canonical_name": "CCR2 chemokine receptor ligand"}
{"concept_id": "C1751410", "aliases": [], "types": ["T044"], "canonical_name": "CCR3 chemokine receptor ligand"}
{"concept_id": "C1751411", "aliases": [], "types": ["T044"], "canonical_name": "CCR4 chemokine receptor binding", "definition": "Binding to a CCR4 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751412", "aliases": [], "types": ["T044"], "canonical_name": "CCR5 chemokine receptor binding", "definition": "Binding to a CCR5 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751413", "aliases": [], "types": ["T044"], "canonical_name": "CCR6 chemokine receptor ligand"}
{"concept_id": "C1751414", "aliases": [], "types": ["T044"], "canonical_name": "CCR7 chemokine receptor ligand"}
{"concept_id": "C1751415", "aliases": [], "types": ["T044"], "canonical_name": "CCR8 chemokine receptor ligand"}
{"concept_id": "C1751416", "aliases": [], "types": ["T044"], "canonical_name": "CCR9 chemokine receptor binding", "definition": "Binding to a CCR9 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751417", "aliases": [], "types": ["T044"], "canonical_name": "CCR10 chemokine receptor binding", "definition": "Binding to a CCR10 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751418", "aliases": [], "types": ["T044"], "canonical_name": "CCR11 chemokine receptor binding", "definition": "Binding to a CCR11 chemokine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751419", "aliases": [], "types": ["T044"], "canonical_name": "CX3C chemokine receptor ligand"}
{"concept_id": "C1751420", "aliases": [], "types": ["T044"], "canonical_name": "XCR1 chemokine receptor ligand"}
{"concept_id": "C1751421", "aliases": [], "types": ["T044"], "canonical_name": "cholecystokinin receptor binding", "definition": "Binding to a cholecystokinin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751422", "aliases": [], "types": ["T044"], "canonical_name": "type A cholecystokinin receptor binding", "definition": "Binding to a type A cholecystokinin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751423", "aliases": [], "types": ["T044"], "canonical_name": "type B gastrin/cholecystokinin receptor ligand"}
{"concept_id": "C1751424", "aliases": [], "types": ["T044"], "canonical_name": "corticotropin releasing factor receptor ligand"}
{"concept_id": "C1751426", "aliases": [], "types": ["T044"], "canonical_name": "type 2 corticotropin releasing factor receptor ligand"}
{"concept_id": "C1751427", "aliases": [], "types": ["T044"], "canonical_name": "cysteinyl leukotriene receptor binding", "definition": "Binding to a cysteinyl leukotriene receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751428", "aliases": [], "types": ["T044"], "canonical_name": "type 1 cysteinyl leukotriene receptor ligand"}
{"concept_id": "C1751429", "aliases": [], "types": ["T044"], "canonical_name": "type 2 cysteinyl leukotriene receptor binding", "definition": "Binding to a type 2 cysteinyl leukotriene receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751430", "aliases": [], "types": ["T044"], "canonical_name": "D1 dopamine receptor ligand"}
{"concept_id": "C1751431", "aliases": [], "types": ["T044"], "canonical_name": "D2 dopamine receptor binding", "definition": "Binding to a D2 dopamine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751432", "aliases": [], "types": ["T044"], "canonical_name": "D3 dopamine receptor ligand"}
{"concept_id": "C1751433", "aliases": [], "types": ["T044"], "canonical_name": "D4 dopamine receptor binding", "definition": "Binding to a D4 dopamine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751434", "aliases": [], "types": ["T044"], "canonical_name": "D5 dopamine receptor ligand"}
{"concept_id": "C1751435", "aliases": ["endothelial differentiation G-protein coupled receptor binding"], "types": ["T044"], "canonical_name": "endothelial differentiation G protein-coupled receptor binding", "definition": "Binding to an endothelial differentiation G protein-coupled receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751436", "aliases": [], "types": ["T044"], "canonical_name": "Edg-1 sphingosine 1-phosphate receptor binding", "definition": "Binding to an Edg-1 sphingosine 1-phosphate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751437", "aliases": [], "types": ["T044"], "canonical_name": "Edg-2 lysophosphatidic acid receptor ligand"}
{"concept_id": "C1751438", "aliases": [], "types": ["T044"], "canonical_name": "Edg-3 sphingosine 1-phosphate receptor ligand"}
{"concept_id": "C1751439", "aliases": [], "types": ["T044"], "canonical_name": "Edg-4 lysophosphatidic acid receptor ligand"}
{"concept_id": "C1751440", "aliases": [], "types": ["T044"], "canonical_name": "Edg-5 sphingosine 1-phosphate receptor ligand"}
{"concept_id": "C1751441", "aliases": [], "types": ["T044"], "canonical_name": "Edg-6 sphingosine 1-phosphate receptor binding", "definition": "Binding to an Edg-6 sphingosine 1-phosphate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751442", "aliases": [], "types": ["T044"], "canonical_name": "Edg-7 lysophosphatidic acid receptor ligand"}
{"concept_id": "C1751443", "aliases": [], "types": ["T044"], "canonical_name": "fMet-Leu-Phe receptor ligand"}
{"concept_id": "C1751444", "aliases": [], "types": ["T044"], "canonical_name": "follicle stimulating hormone receptor ligand"}
{"concept_id": "C1751445", "aliases": [], "types": ["T044"], "canonical_name": "galanin receptor ligand"}
{"concept_id": "C1751446", "aliases": [], "types": ["T044"], "canonical_name": "type 1 galanin receptor binding", "definition": "Binding to a type 1 galanin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751447", "aliases": [], "types": ["T044"], "canonical_name": "type 2 galanin receptor binding", "definition": "Binding to a type 2 galanin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751448", "aliases": [], "types": ["T044"], "canonical_name": "type 3 galanin receptor binding", "definition": "Binding to a type 3 galanin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751449", "aliases": [], "types": ["T044"], "canonical_name": "gastric inhibitory polypeptide receptor ligand"}
{"concept_id": "C1751450", "aliases": [], "types": ["T044"], "canonical_name": "ghrelin receptor ligand"}
{"concept_id": "C1751451", "aliases": [], "types": ["T044"], "canonical_name": "glucagon receptor ligand"}
{"concept_id": "C1751452", "aliases": [], "types": ["T044"], "canonical_name": "growth hormone-releasing hormone receptor ligand"}
{"concept_id": "C1751453", "aliases": [], "types": ["T044"], "canonical_name": "type 1 hypocretin receptor ligand"}
{"concept_id": "C1751454", "aliases": [], "types": ["T044"], "canonical_name": "type 2 hypocretin receptor ligand"}
{"concept_id": "C1751455", "aliases": [], "types": ["T044"], "canonical_name": "kisspeptin receptor ligand"}
{"concept_id": "C1751456", "aliases": [], "types": ["T044"], "canonical_name": "leukotriene receptor ligand"}
{"concept_id": "C1751457", "aliases": [], "types": ["T044"], "canonical_name": "lutropin-choriogonadotropic hormone receptor ligand"}
{"concept_id": "C1751458", "aliases": [], "types": ["T044"], "canonical_name": "melanin-concentrating hormone receptor ligand"}
{"concept_id": "C1751459", "aliases": [], "types": ["T044"], "canonical_name": "type 1 melanin-concentrating hormone receptor ligand"}
{"concept_id": "C1751460", "aliases": [], "types": ["T044"], "canonical_name": "type 2 melanin-concentrating hormone receptor binding", "definition": "Binding to a type 2 melanin-concentrating hormone receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751461", "aliases": [], "types": ["T044"], "canonical_name": "melanocortin receptor binding", "definition": "Binding to a melanocortin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751462", "aliases": [], "types": ["T044"], "canonical_name": "adrenocorticotropic hormone receptor ligand"}
{"concept_id": "C1751463", "aliases": [], "types": ["T044"], "canonical_name": "type 3 melanocortin receptor ligand"}
{"concept_id": "C1751464", "aliases": [], "types": ["T044"], "canonical_name": "type 4 melanocortin receptor ligand"}
{"concept_id": "C1751465", "aliases": [], "types": ["T044"], "canonical_name": "type 5 melanocortin receptor binding", "definition": "Binding to a type 5 melanocortin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751466", "aliases": [], "types": ["T044"], "canonical_name": "melatonin receptor binding", "definition": "Binding to a melatonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751467", "aliases": [], "types": ["T044"], "canonical_name": "type 1A melatonin receptor binding", "definition": "Binding to a type 1A melatonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751468", "aliases": [], "types": ["T044"], "canonical_name": "type 1B melatonin receptor binding", "definition": "Binding to a type 1B melatonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751469", "aliases": [], "types": ["T044"], "canonical_name": "H9 melatonin receptor binding", "definition": "Binding to a H9 melatonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751470", "aliases": [], "types": ["T044"], "canonical_name": "motilin receptor binding", "definition": "Binding to a motilin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751477", "aliases": [], "types": ["T044"], "canonical_name": "metabotropic GABA receptor ligand"}
{"concept_id": "C1751478", "aliases": [], "types": ["T044"], "canonical_name": "type 1 metabotropic GABA receptor ligand"}
{"concept_id": "C1751479", "aliases": [], "types": ["T044"], "canonical_name": "type 2 metabotropic GABA receptor binding", "definition": "Binding to a type 2 metabotropic GABA receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751480", "aliases": [], "types": ["T044"], "canonical_name": "type 1 metabotropic glutamate receptor ligand"}
{"concept_id": "C1751481", "aliases": [], "types": ["T044"], "canonical_name": "type 2 metabotropic glutamate receptor ligand"}
{"concept_id": "C1751482", "aliases": [], "types": ["T044"], "canonical_name": "type 3 metabotropic glutamate receptor binding", "definition": "Binding to a type 3 metabotropic glutamate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751483", "aliases": [], "types": ["T044"], "canonical_name": "type 4 metabotropic glutamate receptor ligand"}
{"concept_id": "C1751484", "aliases": [], "types": ["T044"], "canonical_name": "type 5 metabotropic glutamate receptor ligand"}
{"concept_id": "C1751485", "aliases": [], "types": ["T044"], "canonical_name": "type 6 metabotropic glutamate receptor ligand"}
{"concept_id": "C1751486", "aliases": [], "types": ["T044"], "canonical_name": "type 7 metabotropic glutamate receptor ligand"}
{"concept_id": "C1751487", "aliases": [], "types": ["T044"], "canonical_name": "type 8 metabotropic glutamate receptor binding", "definition": "Binding to a type 8 metabotropic glutamate receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751488", "aliases": [], "types": ["T044"], "canonical_name": "metabotropic histamine receptor ligand"}
{"concept_id": "C1751489", "aliases": [], "types": ["T044"], "canonical_name": "H1 histamine receptor ligand"}
{"concept_id": "C1751490", "aliases": [], "types": ["T044"], "canonical_name": "H2 histamine receptor ligand"}
{"concept_id": "C1751491", "aliases": [], "types": ["T044"], "canonical_name": "H3 histamine receptor binding", "definition": "Binding to a H3 histamine receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751492", "aliases": [], "types": ["T044"], "canonical_name": "H4 histamine receptor ligand"}
{"concept_id": "C1751493", "aliases": [], "types": ["T044"], "canonical_name": "metabotropic nucleotide receptor ligand"}
{"concept_id": "C1751494", "aliases": [], "types": ["T044"], "canonical_name": "P2Y1 nucleotide receptor binding", "definition": "Binding to a P2Y1 nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751495", "aliases": [], "types": ["T044"], "canonical_name": "P2Y2 nucleotide receptor binding", "definition": "Binding to a P2Y2 nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751496", "aliases": [], "types": ["T044"], "canonical_name": "P2Y4 nucleotide receptor ligand"}
{"concept_id": "C1751497", "aliases": [], "types": ["T044"], "canonical_name": "P2Y5 nucleotide receptor binding", "definition": "Binding to a P2Y5 nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751498", "aliases": [], "types": ["T044"], "canonical_name": "P2Y6 nucleotide receptor binding", "definition": "Binding to a P2Y6 nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751499", "aliases": [], "types": ["T044"], "canonical_name": "P2Y8 nucleotide receptor binding", "definition": "Binding to a P2Y8 nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751500", "aliases": [], "types": ["T044"], "canonical_name": "P2Y9 nucleotide receptor binding", "definition": "Binding to a P2Y9 nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751501", "aliases": [], "types": ["T044"], "canonical_name": "P2Y10 nucleotide receptor binding", "definition": "Binding to a P2Y10 nucleotide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751502", "aliases": [], "types": ["T044"], "canonical_name": "P2Y11 nucleotide receptor ligand"}
{"concept_id": "C1751503", "aliases": [], "types": ["T044"], "canonical_name": "metabotropic serotonin receptor ligand"}
{"concept_id": "C1751504", "aliases": [], "types": ["T044"], "canonical_name": "type 1B serotonin receptor ligand"}
{"concept_id": "C1751505", "aliases": [], "types": ["T044"], "canonical_name": "type 1D serotonin receptor ligand"}
{"concept_id": "C1751506", "aliases": [], "types": ["T044"], "canonical_name": "type 1E serotonin receptor ligand"}
{"concept_id": "C1751507", "aliases": [], "types": ["T044"], "canonical_name": "type 1F serotonin receptor ligand"}
{"concept_id": "C1751508", "aliases": [], "types": ["T044"], "canonical_name": "type 2A serotonin receptor ligand"}
{"concept_id": "C1751509", "aliases": [], "types": ["T044"], "canonical_name": "type 2B serotonin receptor ligand"}
{"concept_id": "C1751510", "aliases": [], "types": ["T044"], "canonical_name": "type 2C serotonin receptor ligand"}
{"concept_id": "C1751511", "aliases": ["5-hydroxytryptamine 4 receptor binding"], "types": ["T044"], "canonical_name": "type 4 serotonin receptor binding", "definition": "Binding to a type 4 serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751512", "aliases": [], "types": ["T044"], "canonical_name": "type 5A serotonin receptor ligand"}
{"concept_id": "C1751513", "aliases": ["5-hydroxytryptamine 5B receptor binding"], "types": ["T044"], "canonical_name": "type 5B serotonin receptor binding", "definition": "Binding to a type 5B serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751514", "aliases": ["5-hydroxytryptamine 6 receptor binding"], "types": ["T044"], "canonical_name": "type 6 serotonin receptor binding", "definition": "Binding to a type 6 serotonin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751515", "aliases": [], "types": ["T044"], "canonical_name": "type 7 serotonin receptor ligand"}
{"concept_id": "C1751516", "aliases": [], "types": ["T044"], "canonical_name": "neurokinin receptor ligand"}
{"concept_id": "C1751517", "aliases": [], "types": ["T044"], "canonical_name": "substance P receptor ligand"}
{"concept_id": "C1751518", "aliases": ["neurokinin-B receptor binding"], "types": ["T044"], "canonical_name": "neuromedin K receptor binding", "definition": "Binding to a neuromedin K receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751519", "aliases": [], "types": ["T044"], "canonical_name": "substance K receptor ligand"}
{"concept_id": "C1751520", "aliases": [], "types": ["T044"], "canonical_name": "type 1 neuromedin U receptor binding", "definition": "Binding to a type 1 neuromedin U receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751521", "aliases": [], "types": ["T044"], "canonical_name": "type 2 neuromedin U receptor ligand"}
{"concept_id": "C1751522", "aliases": ["NPY receptor binding"], "types": ["T044"], "canonical_name": "neuropeptide Y receptor binding", "definition": "Binding to a neuropeptide Y receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751523", "aliases": [], "types": ["T044"], "canonical_name": "type 1 neuropeptide Y receptor ligand"}
{"concept_id": "C1751524", "aliases": [], "types": ["T044"], "canonical_name": "type 2 neuropeptide Y receptor ligand"}
{"concept_id": "C1751525", "aliases": [], "types": ["T044"], "canonical_name": "type 4 neuropeptide Y receptor ligand"}
{"concept_id": "C1751526", "aliases": [], "types": ["T044"], "canonical_name": "type 5 neuropeptide Y receptor ligand"}
{"concept_id": "C1751527", "aliases": [], "types": ["T044"], "canonical_name": "neurotensin receptor binding", "definition": "Binding to a neurotensin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751528", "aliases": [], "types": ["T044"], "canonical_name": "type 1 neurotensin receptor binding", "definition": "Binding to a type 1 neurotensin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751529", "aliases": [], "types": ["T044"], "canonical_name": "olfactory receptor binding", "definition": "Binding to an olfactory receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751530", "aliases": [], "types": ["T044"], "canonical_name": "delta-type opioid receptor ligand"}
{"concept_id": "C1751531", "aliases": [], "types": ["T044"], "canonical_name": "kappa-type opioid receptor binding", "definition": "Binding to a kappa-type opioid receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751532", "aliases": [], "types": ["T044"], "canonical_name": "mu-type opioid receptor ligand"}
{"concept_id": "C1751533", "aliases": [], "types": ["T044"], "canonical_name": "nociceptin receptor binding", "definition": "Binding to a nociceptin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751534", "aliases": [], "types": ["T044"], "canonical_name": "orexigenic neuropeptide QRFP receptor binding", "definition": "Binding to an orexigenic neuropeptide QRFP receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751535", "aliases": [], "types": ["T044"], "canonical_name": "oxytocin receptor binding", "definition": "Binding to an oxytocin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751536", "aliases": [], "types": ["T044"], "canonical_name": "parathyroid hormone receptor ligand"}
{"concept_id": "C1751537", "aliases": [], "types": ["T044"], "canonical_name": "type 1 parathyroid hormone receptor ligand"}
{"concept_id": "C1751538", "aliases": ["PACAP receptor binding", "pituitary adenylate cyclase activating peptide receptor binding"], "types": ["T044"], "canonical_name": "pituitary adenylate cyclase-activating polypeptide receptor binding", "definition": "Binding to a pituitary adenylate cyclase-activating polypeptide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751539", "aliases": [], "types": ["T044"], "canonical_name": "platelet activating factor receptor ligand"}
{"concept_id": "C1751540", "aliases": [], "types": ["T044"], "canonical_name": "prolactin-releasing peptide receptor binding", "definition": "Binding to a prolactin-releasing peptide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751541", "aliases": [], "types": ["T044"], "canonical_name": "prostanoid receptor binding", "definition": "Binding to a prostanoid receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751542", "aliases": ["prostanoid DP receptor binding"], "types": ["T044"], "canonical_name": "prostaglandin D2 receptor binding", "definition": "Binding to a prostaglandin D2 receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751548", "aliases": ["prostanoid IP receptor binding"], "types": ["T044"], "canonical_name": "prostacyclin receptor binding", "definition": "Binding to a prostacyclin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751549", "aliases": ["prostanoid TP receptor binding"], "types": ["T044"], "canonical_name": "thromboxane A2 receptor binding", "definition": "Binding to a thromboxane A2 receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751550", "aliases": [], "types": ["T044"], "canonical_name": "proteinase activated receptor binding", "definition": "Binding to a proteinase activated receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751551", "aliases": [], "types": ["T044"], "canonical_name": "type 1 proteinase activated receptor ligand"}
{"concept_id": "C1751552", "aliases": [], "types": ["T044"], "canonical_name": "type 2 proteinase activated receptor binding", "definition": "Binding to a type 2 proteinase activated receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751553", "aliases": [], "types": ["T044"], "canonical_name": "type 3 proteinase activated receptor binding", "definition": "Binding to a type 3 proteinase activated receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751554", "aliases": [], "types": ["T044"], "canonical_name": "type 4 proteinase activated receptor ligand"}
{"concept_id": "C1751555", "aliases": [], "types": ["T044"], "canonical_name": "secretin receptor binding", "definition": "Binding to a secretin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751556", "aliases": [], "types": ["T044"], "canonical_name": "somatostatin receptor binding", "definition": "Binding to a somatostatin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751557", "aliases": [], "types": ["T044"], "canonical_name": "type 1 somatostatin receptor binding", "definition": "Binding to a type 1 somatostatin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751558", "aliases": [], "types": ["T044"], "canonical_name": "type 2 somatostatin receptor binding", "definition": "Binding to a type 2 somatostatin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751559", "aliases": [], "types": ["T044"], "canonical_name": "type 3 somatostatin receptor ligand"}
{"concept_id": "C1751560", "aliases": [], "types": ["T044"], "canonical_name": "type 4 somatostatin receptor binding", "definition": "Binding to a type 4 somatostatin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751561", "aliases": [], "types": ["T044"], "canonical_name": "type 5 somatostatin receptor binding", "definition": "Binding to a type 5 somatostatin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751562", "aliases": [], "types": ["T044"], "canonical_name": "taste receptor binding", "definition": "Binding to a taste receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751563", "aliases": [], "types": ["T044"], "canonical_name": "type 1 member 1 taste receptor binding", "definition": "Binding to a type 1 member 1 taste receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751564", "aliases": [], "types": ["T044"], "canonical_name": "type 1 member 2 taste receptor binding", "definition": "Binding to a type 1 member 2 taste receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751565", "aliases": [], "types": ["T044"], "canonical_name": "type 1 member 3 taste receptor ligand"}
{"concept_id": "C1751566", "aliases": [], "types": ["T044"], "canonical_name": "urotensin receptor binding", "definition": "Binding to a urotensin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751567", "aliases": [], "types": ["T044"], "canonical_name": "vasoactive intestinal polypeptide receptor ligand"}
{"concept_id": "C1751568", "aliases": [], "types": ["T044"], "canonical_name": "type 1 vasoactive intestinal polypeptide receptor ligand"}
{"concept_id": "C1751569", "aliases": ["type 3 PACAP receptor binding"], "types": ["T044"], "canonical_name": "type 2 vasoactive intestinal polypeptide receptor binding", "definition": "Binding to a type 2 vasoactive intestinal polypeptide receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751571", "aliases": [], "types": ["T044"], "canonical_name": "V1A vasopressin receptor binding", "definition": "Binding to a V1A vasopressin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751572", "aliases": [], "types": ["T044"], "canonical_name": "V1B vasopressin receptor binding", "definition": "Binding to a V1B vasopressin receptor. [GOC:mah, GOC:nln]"}
{"concept_id": "C1751573", "aliases": [], "types": ["T044"], "canonical_name": "V2 vasopressin receptor ligand"}
{"concept_id": "C1751580", "aliases": [], "types": ["T044"], "canonical_name": "short-chain fatty acid activation"}
{"concept_id": "C1751581", "aliases": ["medium-chain-fatty-acid-CoA ligase activity", "medium-chain fatty-acid-CoA ligase activity"], "types": ["T044"], "canonical_name": "medium-chain fatty acid-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12. [GOC:mah, RHEA:48340]"}
{"concept_id": "C1751582", "aliases": ["very-long-chain fatty acid-CoA ligase activity", "very-long-chain-fatty-acid-CoA ligase activity"], "types": ["T044"], "canonical_name": "very long-chain fatty acid-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22. [GOC:mah, PMID:18024425]"}
{"concept_id": "C1751583", "aliases": [], "types": ["T044"], "canonical_name": "energy transducer activity", "definition": "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell. [GOC:go_curators]"}
{"concept_id": "C1751585", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-28 receptor ligand"}
{"concept_id": "C1752410", "aliases": [], "types": ["T045"], "canonical_name": "spermatogenesis, exchange of chromosomal proteins", "definition": "The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin. [GOC:bf, PMID:11735001]"}
{"concept_id": "C1752411", "aliases": [], "types": ["T045"], "canonical_name": "sterol regulatory element binding protein target gene transcriptional activation"}
{"concept_id": "C1752412", "aliases": [], "types": ["T043"], "canonical_name": "tracheal cell type specification"}
{"concept_id": "C1752413", "aliases": ["regulation of tracheal tube diameter"], "types": ["T040"], "canonical_name": "regulation of tube diameter, open tracheal system", "definition": "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size. [GOC:mtg_sensu, PMID:14570584]"}
{"concept_id": "C1752414", "aliases": [], "types": ["T042"], "canonical_name": "tracheal tube elongation"}
{"concept_id": "C1752417", "aliases": [], "types": ["T055"], "canonical_name": "behavioral response to salt"}
{"concept_id": "C1752418", "aliases": [], "types": ["T042"], "canonical_name": "tracheal placode invagination"}
{"concept_id": "C1752420", "aliases": [], "types": ["T042"], "canonical_name": "anterior head segmentation", "definition": "Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments. [PMID:15382136]"}
{"concept_id": "C1752421", "aliases": [], "types": ["T040"], "canonical_name": "gnathal segmentation"}
{"concept_id": "C1752422", "aliases": ["wing hair outgrowth"], "types": ["T044"], "canonical_name": "imaginal disc-derived wing hair outgrowth", "definition": "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair. [GOC:mtg_sensu, PMID:11064425, PMID:8947551]"}
{"concept_id": "C1752423", "aliases": [], "types": ["T044"], "canonical_name": "wing prehair extension"}
{"concept_id": "C1752424", "aliases": ["wing hair site selection"], "types": ["T043"], "canonical_name": "imaginal disc-derived wing hair site selection", "definition": "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally. [GOC:mtg_transport, ISBN:0815340729, PMID:8947551]"}
{"concept_id": "C1752425", "aliases": ["regulation of body size", "regulation of body growth"], "types": ["T040"], "canonical_name": "regulation of multicellular organism growth", "definition": "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. [GOC:dph, GOC:ems, GOC:tb]"}
{"concept_id": "C1752426", "aliases": [], "types": ["T040"], "canonical_name": "developmental timing"}
{"concept_id": "C1752433", "aliases": ["Rad51-mediated strand invasion"], "types": ["T045"], "canonical_name": "strand invasion", "definition": "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. [GOC:elh, PMID:10357855]"}
{"concept_id": "C1752435", "aliases": [], "types": ["T043"], "canonical_name": "killer activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1752436", "aliases": ["natural killer-cell mediated cytolysis", "NK cell mediated cytolysis"], "types": ["T043"], "canonical_name": "natural killer cell mediated cytolysis"}
{"concept_id": "C1752437", "aliases": ["regulation of NK cell mediated cytolysis", "regulation of natural killer-cell mediated cytolysis"], "types": ["T043"], "canonical_name": "regulation of natural killer cell mediated cytolysis"}
{"concept_id": "C1752438", "aliases": ["protection from NK cell mediated cytolysis"], "types": ["T043"], "canonical_name": "protection from natural killer cell mediated cytolysis"}
{"concept_id": "C1752442", "aliases": ["error-free PRR"], "types": ["T045"], "canonical_name": "error-free postreplication DNA repair", "definition": "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate. [GOC:elh, GOC:jl, PMID:11459630]"}
{"concept_id": "C1752443", "aliases": ["mutagenic postreplication DNA repair", "error-prone postreplication DNA repair", "mutagenic PRR"], "types": ["T045"], "canonical_name": "error-prone translesion synthesis", "definition": "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. [GOC:elh, GOC:jl, PMID:11485998]"}
{"concept_id": "C1752445", "aliases": [], "types": ["T044"], "canonical_name": "major histocompatibility complex ligand"}
{"concept_id": "C1752446", "aliases": ["orexin receptor ligand"], "types": ["T044"], "canonical_name": "hypocretin receptor ligand"}
{"concept_id": "C1752449", "aliases": [], "types": ["T044"], "canonical_name": "cholecalciferol metabolism"}
{"concept_id": "C1752451", "aliases": [], "types": ["T044"], "canonical_name": "ergocalciferol metabolism"}
{"concept_id": "C1752453", "aliases": [], "types": ["T044"], "canonical_name": "alpha-tocopherol metabolism"}
{"concept_id": "C1752457", "aliases": [], "types": ["T044"], "canonical_name": "chemokine receptor binding", "definition": "Binding to a chemokine receptor. [GOC:ai]"}
{"concept_id": "C1752459", "aliases": ["detection of Lpp"], "types": ["T044"], "canonical_name": "perception of Lpp"}
{"concept_id": "C1752460", "aliases": [], "types": ["T040"], "definition": "The ability of organisms to sense and adapt to high concentrations of salt in their growth environment.", "canonical_name": "salt tolerance"}
{"concept_id": "C1752463", "aliases": [], "types": ["T044"], "canonical_name": "taxol metabolism"}
{"concept_id": "C1752466", "aliases": [], "types": ["T044"], "canonical_name": "PHA metabolism"}
{"concept_id": "C1752468", "aliases": [], "types": ["T040"], "canonical_name": "catagen", "definition": "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced. [PMID:12535193]"}
{"concept_id": "C1752469", "aliases": [], "types": ["T040"], "canonical_name": "exogen", "definition": "The shedding phase of the hair cycle. [PMID:12230507]"}
{"concept_id": "C1752470", "aliases": ["hair resting phase"], "types": ["T040"], "canonical_name": "telogen", "definition": "The resting phase of hair cycle. [PMID:12230507]"}
{"concept_id": "C1752472", "aliases": [], "types": ["T044"], "canonical_name": "ecdysis-triggering hormone binding"}
{"concept_id": "C1752474", "aliases": ["Tim9-Tim10 complex location"], "types": ["T026"], "canonical_name": "Tim9-Tim10 complex"}
{"concept_id": "C1752476", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen peroxide removal"}
{"concept_id": "C1752477", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial electron transport"}
{"concept_id": "C1752478", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial proton transport"}
{"concept_id": "C1752480", "aliases": ["RNase Z activity"], "types": ["T044"], "canonical_name": "ribonuclease Z activity"}
{"concept_id": "C1752485", "aliases": [], "types": ["T026"], "canonical_name": "active ribosome"}
{"concept_id": "C1752487", "aliases": [], "types": ["T044"], "canonical_name": "protein homodimerization activity", "definition": "Binding to an identical protein to form a homodimer. [GOC:jl]"}
{"concept_id": "C1752488", "aliases": [], "types": ["T043"], "canonical_name": "monopolar cell elongation"}
{"concept_id": "C1752489", "aliases": [], "types": ["T043"], "canonical_name": "monopolar growth"}
{"concept_id": "C1752491", "aliases": [], "types": ["T044"], "canonical_name": "dihydric alcohol metabolism"}
{"concept_id": "C1752492", "aliases": [], "types": ["T044"], "canonical_name": "dihydric alcohol biosynthesis"}
{"concept_id": "C1752495", "aliases": [], "types": ["T044"], "canonical_name": "dihydric alcohol catabolism"}
{"concept_id": "C1752504", "aliases": [], "types": ["T044"], "canonical_name": "methylsterol hydroxylase activity"}
{"concept_id": "C1752505", "aliases": [], "types": ["T044"], "canonical_name": "methylsterol monooxygenase activity"}
{"concept_id": "C1752508", "aliases": ["proton-transporting ATP synthase complex, catalytic core F(1)", "proton-transporting ATP synthase complex location, catalytic core F(1)"], "types": ["T026"], "definition": "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. [GOC:mah, PMID:10838056]", "canonical_name": "hydrogen-transporting ATP synthase, F1 sector"}
{"concept_id": "C1752714", "aliases": [], "types": ["T044"], "canonical_name": "beta-ketoadipate pathway", "definition": "A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. [GOC:jl, PMID:8905091]"}
{"concept_id": "C1752715", "aliases": [], "types": ["T044"], "canonical_name": "acridine efflux pump activity"}
{"concept_id": "C1752716", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of JAK2 protein"}
{"concept_id": "C1752717", "aliases": [], "types": ["T044"], "canonical_name": "ornithine decarboxylase activator activity", "definition": "Binds to and increases ornithine decarboxylase activity. [GOC:jl]"}
{"concept_id": "C1752719", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sperm-oocyte fusion"}
{"concept_id": "C1752720", "aliases": ["down regulation of fusion of sperm to egg plasma membrane", "downregulation of fusion of sperm to egg plasma membrane", "down-regulation of fusion of sperm to egg plasma membrane"], "types": ["T043"], "canonical_name": "negative regulation of fusion of sperm to egg plasma membrane", "definition": "Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane. [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]"}
{"concept_id": "C1752721", "aliases": ["de novo DNA methylation"], "types": ["T045"], "canonical_name": "de novo DNA methylation"}
{"concept_id": "C1752722", "aliases": [], "types": ["T039"], "canonical_name": "pharyngeal pumping", "definition": "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes. [GOC:cab1, PMID:2181052]"}
{"concept_id": "C1752723", "aliases": [], "types": ["T043"], "canonical_name": "social gliding motility"}
{"concept_id": "C1752724", "aliases": [], "types": ["T043"], "canonical_name": "twitching motility"}
{"concept_id": "C1752725", "aliases": ["regulation of smoothened activity"], "types": ["T044"], "canonical_name": "regulation of smoothened by patched"}
{"concept_id": "C1752726", "aliases": [], "types": ["T044"], "canonical_name": "proteasomal processing"}
{"concept_id": "C1752727", "aliases": [], "types": ["T044"], "canonical_name": "proteasome pathway"}
{"concept_id": "C1752728", "aliases": [], "types": ["T044"], "canonical_name": "ion binding", "definition": "Binding to an ion, a charged atoms or groups of atoms. [GOC:jl]"}
{"concept_id": "C1752729", "aliases": [], "types": ["T044"], "canonical_name": "KDR binding"}
{"concept_id": "C1752738", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of potassium ion conductance"}
{"concept_id": "C1752739", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of K+ conductance"}
{"concept_id": "C1752740", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of potassium conductance"}
{"concept_id": "C1752741", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of potassium ion conductance"}
{"concept_id": "C1752742", "aliases": [], "types": ["T044"], "canonical_name": "regulation of caspase activity"}
{"concept_id": "C1752743", "aliases": [], "types": ["T026"], "canonical_name": "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes"}
{"concept_id": "C1752744", "aliases": ["contractile fibre"], "types": ["T026"], "canonical_name": "contractile fiber", "definition": "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. [GOC:go_curators, ISBN:0815316194]"}
{"concept_id": "C1752745", "aliases": [], "types": ["T026"], "canonical_name": "mating projection tip", "definition": "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth. [GOC:mcc]"}
{"concept_id": "C1752752", "aliases": [], "types": ["T044"], "canonical_name": "anthranilic acid metabolism"}
{"concept_id": "C1752755", "aliases": [], "types": ["T044"], "canonical_name": "anthranilic acid catabolism"}
{"concept_id": "C1752766", "aliases": [], "types": ["T045"], "canonical_name": "CRISPR element metabolism"}
{"concept_id": "C1752767", "aliases": [], "types": ["T042"], "canonical_name": "glossa development"}
{"concept_id": "C1752768", "aliases": [], "types": ["T042"], "canonical_name": "lingua development"}
{"concept_id": "C1752769", "aliases": [], "types": ["T042"], "canonical_name": "glossa morphogenesis"}
{"concept_id": "C1752770", "aliases": [], "types": ["T026"], "canonical_name": "epispore"}
{"concept_id": "C1752771", "aliases": [], "types": ["T026"], "canonical_name": "exospore"}
{"concept_id": "C1752851", "aliases": [], "types": ["T044"], "canonical_name": "sulfur biosynthesis"}
{"concept_id": "C1752854", "aliases": [], "types": ["T044"], "canonical_name": "sulfur catabolism"}
{"concept_id": "C1752856", "aliases": [], "types": ["T040"], "definition": "The interactions between a host and a pathogen, usually resulting in disease.", "canonical_name": "host-pathogen interaction"}
{"concept_id": "C1752857", "aliases": [], "types": ["T040"], "canonical_name": "symbiotic interaction between host and organism"}
{"concept_id": "C1752902", "aliases": ["SDSA"], "types": ["T045"], "canonical_name": "double-strand break repair via synthesis-dependent strand annealing", "definition": "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. [PMID:10357855]"}
{"concept_id": "C1752904", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane fusion", "definition": "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. [GOC:elh, GOC:mtg_muscle]"}
{"concept_id": "C1752908", "aliases": [], "types": ["T043"], "canonical_name": "bouquet formation"}
{"concept_id": "C1752909", "aliases": [], "types": ["T044"], "canonical_name": "antisigma factor antagonist activity"}
{"concept_id": "C1752913", "aliases": ["alpha chemokine receptor binding"], "types": ["T044"], "canonical_name": "CXCR chemokine receptor binding", "definition": "Binding to a chemokine receptor in the CXCR family. [GOC:ceb, PMID:11910892]"}
{"concept_id": "C1752914", "aliases": [], "types": ["T044"], "canonical_name": "CXCR1 chemokine receptor ligand"}
{"concept_id": "C1752915", "aliases": [], "types": ["T044"], "canonical_name": "CXCR2 chemokine receptor ligand"}
{"concept_id": "C1752917", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphorylated amino acid binding", "definition": "Binding to a phosphorylated amino acid residue within a protein. [GOC:go_curators]"}
{"concept_id": "C1752918", "aliases": ["leucocyanidin oxygenase activity", "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O. [EC:1.14.20.4, MetaCyc:1.14.11.19-RXN]", "canonical_name": "leucoanthocyanidin dioxygenase activity"}
{"concept_id": "C1752923", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-22 receptor ligand"}
{"concept_id": "C1752924", "aliases": ["interleukin-27 receptor binding"], "types": ["T044"], "definition": "Binding to an interleukin-27 receptor. [GOC:go_curators]", "canonical_name": "IL-27"}
{"concept_id": "C1752925", "aliases": ["negative regulation of cyclin-dependent protein serine/threonine kinase activity", "down regulation of cyclin-dependent protein kinase activity", "down-regulation of cyclin-dependent protein kinase activity", "negative regulation of cyclin-dependent protein kinase activity"], "types": ["T043"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr]", "canonical_name": "downregulation of cyclin-dependent protein kinase activity"}
{"concept_id": "C1752926", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of budding"}
{"concept_id": "C1752927", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of budding"}
{"concept_id": "C1752928", "aliases": ["negative regulation of cuticle tanning", "downregulation of cuticle tanning", "down-regulation of cuticle tanning", "down regulation of cuticle tanning"], "types": ["T038"], "canonical_name": "negative regulation of chitin-based cuticle tanning", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of chitin-based cuticular tanning. [GOC:go_curators, GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1752929", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of cuticle hardening"}
{"concept_id": "C1752930", "aliases": [], "types": ["T043"], "canonical_name": "mitogenic activity"}
{"concept_id": "C1752931", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of smoothened activity"}
{"concept_id": "C1752933", "aliases": ["negative regulation of NK cell mediated cytolysis"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell mediated cytolysis"}
{"concept_id": "C1752934", "aliases": ["positive regulation of NK cell mediated cytolysis"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell mediated cytolysis"}
{"concept_id": "C1752949", "aliases": [], "types": ["T045"], "canonical_name": "lariat RNA formation"}
{"concept_id": "C1752950", "aliases": [], "types": ["T045"], "canonical_name": "U2-type spliceosome conformational change to release U4 and U1"}
{"concept_id": "C1752995", "aliases": [], "types": ["T045"], "canonical_name": "meiotic strand invasion", "definition": "The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis. [GOC:elh, PMID:10915877]"}
{"concept_id": "C1753022", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP98A3"}
{"concept_id": "C1753023", "aliases": [], "types": ["T044"], "canonical_name": "sulfolipid synthase"}
{"concept_id": "C1753028", "aliases": [], "types": ["T044"], "canonical_name": "KLRC4 receptor binding"}
{"concept_id": "C1753029", "aliases": [], "types": ["T044"], "canonical_name": "NKG2D receptor binding"}
{"concept_id": "C1753032", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphorylation"}
{"concept_id": "C1753034", "aliases": [], "types": ["T044"], "canonical_name": "porphyrin binding"}
{"concept_id": "C1753035", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein. [GOC:jl, ISBN:0124325653]", "canonical_name": "heavy metal chelation"}
{"concept_id": "C1753037", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-alanine N-carbamylation"}
{"concept_id": "C1753044", "aliases": ["beta chemokine receptor ligand"], "types": ["T044"], "canonical_name": "CCR chemokine receptor ligand"}
{"concept_id": "C1753045", "aliases": ["regulation of nuclear mRNA splicing, via spliceosome"], "types": ["T045"], "canonical_name": "regulation of mRNA splicing, via spliceosome", "definition": "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. [GOC:jid]"}
{"concept_id": "C1753048", "aliases": [], "types": ["T044"], "canonical_name": "polygalacturonide binding"}
{"concept_id": "C1753051", "aliases": [], "types": ["T043"], "canonical_name": "formation of dictyosome membrane priming complex"}
{"concept_id": "C1753052", "aliases": [], "types": ["T043"], "canonical_name": "Golgi membrane coat protein complex assembly", "definition": "The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]"}
{"concept_id": "C1753053", "aliases": [], "types": ["T043"], "canonical_name": "dictyosome vesicle targeting"}
{"concept_id": "C1753054", "aliases": [], "types": ["T043"], "canonical_name": "vesicle targeting, to, from or within dictyosome"}
{"concept_id": "C1753055", "aliases": [], "types": ["T043"], "canonical_name": "dictyosome transport vesicle coating"}
{"concept_id": "C1753056", "aliases": [], "types": ["T043"], "canonical_name": "dictyosome vesicle fusion to target membrane"}
{"concept_id": "C1753057", "aliases": [], "types": ["T043"], "canonical_name": "dictyosome vesicle prefusion complex stabilisation"}
{"concept_id": "C1753058", "aliases": ["male gametophyte sperm cell differentiation", "sperm cell differentiation"], "types": ["T043"], "canonical_name": "pollen sperm cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte. [CL:0000366, GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1753059", "aliases": [], "types": ["T040"], "canonical_name": "androecium development", "definition": "The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C1753060", "aliases": ["Mus81-Eme1 complex", "Mus81-Eme1 complex location"], "types": ["T026"], "canonical_name": "Mus81-Eme1 complex"}
{"concept_id": "C1753061", "aliases": [], "types": ["T043"], "canonical_name": "replication fork protection", "definition": "Any process that prevents the collapse of stalled replication forks. [GOC:vw, PMID:14560029]"}
{"concept_id": "C1753062", "aliases": [], "types": ["T044"], "canonical_name": "Roundabout receptor binding"}
{"concept_id": "C1753064", "aliases": [], "types": ["T042"], "canonical_name": "timing of organ formation"}
{"concept_id": "C1753065", "aliases": [], "types": ["T038"], "canonical_name": "timing of cell differentiation"}
{"concept_id": "C1753077", "aliases": [], "types": ["T038"], "canonical_name": "proboscis development", "definition": "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure. [GOC:rc]"}
{"concept_id": "C1753129", "aliases": ["neurite biosynthesis", "neurite morphogenesis", "neurite growth", "neurite formation"], "types": ["T043"], "canonical_name": "neuron projection morphogenesis", "definition": "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. [GOC:mah]"}
{"concept_id": "C1753263", "aliases": ["vitamin B12 reduction"], "types": ["T044"], "canonical_name": "vitamin B12 reduction", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1753269", "aliases": [], "types": ["T044"], "canonical_name": "nuclear hormone receptor"}
{"concept_id": "C1753271", "aliases": ["transforming growth factor beta ligand binding to type I receptor"], "types": ["T044"], "canonical_name": "transforming growth factor beta ligand binding to type I receptor", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1753272", "aliases": [], "types": ["T026"], "canonical_name": "septate desmosome"}
{"concept_id": "C1753273", "aliases": [], "types": ["T026"], "canonical_name": "sodium pump"}
{"concept_id": "C1753274", "aliases": [], "types": ["T044"], "canonical_name": "aquaporin"}
{"concept_id": "C1753275", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I. [ISBN:0198547684]", "canonical_name": "plastocyanin"}
{"concept_id": "C1753276", "aliases": [], "types": ["T026"], "canonical_name": "Golgi-associated vesicle", "definition": "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. [GOC:mah]"}
{"concept_id": "C1753277", "aliases": [], "types": ["T045"], "canonical_name": "strand transferase"}
{"concept_id": "C1753279", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2G1"}
{"concept_id": "C1753283", "aliases": ["GH activity", "growth hormone activity"], "types": ["T044"], "definition": "The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth. [GOC:BHF, GOC:mah, PMID:11445442]", "canonical_name": "growth hormone"}
{"concept_id": "C1753284", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 1, intrinsic regulator activity"}
{"concept_id": "C1753285", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 2B, intrinsic regulator activity"}
{"concept_id": "C1753286", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 4, intrinsic regulator activity"}
{"concept_id": "C1753289", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome c reductase activity"}
{"concept_id": "C1753290", "aliases": ["P450 nitric oxide reductase activity"], "types": ["T044"], "canonical_name": "P450nor"}
{"concept_id": "C1753292", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome bc nitric oxide reductase activity"}
{"concept_id": "C1753294", "aliases": [], "types": ["T044"], "canonical_name": "G1/S-specific cyclin"}
{"concept_id": "C1753295", "aliases": [], "types": ["T044"], "canonical_name": "G2/M-specific cyclin"}
{"concept_id": "C1753296", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-dependent protein kinase, intrinsic regulator activity"}
{"concept_id": "C1753297", "aliases": [], "types": ["T044"], "canonical_name": "L-ornithine carboxy-lyase activity"}
{"concept_id": "C1753298", "aliases": [], "types": ["T044"], "canonical_name": "L-hydroxyaminoacid dehydratase activity"}
{"concept_id": "C1753299", "aliases": [], "types": ["T044"], "canonical_name": "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity"}
{"concept_id": "C1753300", "aliases": [], "types": ["T044"], "canonical_name": "nicotinic acid mononucleotide adenylyltransferase"}
{"concept_id": "C1753302", "aliases": [], "types": ["T044"], "canonical_name": "surface antigen variation"}
{"concept_id": "C1753303", "aliases": [], "types": ["T040"], "canonical_name": "control of blood pressure"}
{"concept_id": "C1753304", "aliases": [], "types": ["T040"], "canonical_name": "blood pressure homeostasis"}
{"concept_id": "C1753307", "aliases": [], "types": ["T044"], "canonical_name": "neoxanthin cleavage enzyme"}
{"concept_id": "C1753308", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2A5"}
{"concept_id": "C1753309", "aliases": [], "types": ["T044"], "canonical_name": "glycine receptor"}
{"concept_id": "C1753310", "aliases": [], "types": ["T045"], "canonical_name": "snRNP recycling"}
{"concept_id": "C1753311", "aliases": [], "types": ["T044"], "canonical_name": "platelet-derived growth factor receptor ligand"}
{"concept_id": "C1753312", "aliases": [], "types": ["T044"], "canonical_name": "prolactin receptor ligand"}
{"concept_id": "C1753313", "aliases": [], "types": ["T044"], "canonical_name": "angiotensin receptor ligand"}
{"concept_id": "C1753314", "aliases": [], "types": ["T026"], "canonical_name": "storage"}
{"concept_id": "C1753315", "aliases": [], "types": ["T043"], "canonical_name": "retention"}
{"concept_id": "C1753316", "aliases": [], "types": ["T043"], "canonical_name": "sequestering"}
{"concept_id": "C1753319", "aliases": [], "types": ["T026"], "definition": "The small subunit of the 80s ribosome of eukaryotes. It is composed of the 18S RIBOSOMAL RNA and 32 different RIBOSOMAL PROTEINS.", "canonical_name": "40S ribosomal subunit"}
{"concept_id": "C1753322", "aliases": ["TRAP complex"], "types": ["T026"], "canonical_name": "TRAP complex location"}
{"concept_id": "C1753326", "aliases": [], "types": ["T044"], "canonical_name": "G10D receptor"}
{"concept_id": "C1753327", "aliases": [], "types": ["T044"], "canonical_name": "biogenic amine receptor"}
{"concept_id": "C1753328", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome b561"}
{"concept_id": "C1753329", "aliases": [], "types": ["T044"], "canonical_name": "carnitine O-acetyltransferase I activity"}
{"concept_id": "C1753330", "aliases": [], "types": ["T044"], "canonical_name": "carnitine O-acetyltransferase II activity"}
{"concept_id": "C1753331", "aliases": [], "types": ["T044"], "canonical_name": "BLT receptor"}
{"concept_id": "C1753332", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2F2"}
{"concept_id": "C1753333", "aliases": [], "types": ["T044"], "canonical_name": "NMN amidohydrolase"}
{"concept_id": "C1753334", "aliases": ["phosphodiesterase"], "types": ["T044"], "canonical_name": "phosphodiesterase activity"}
{"concept_id": "C1753335", "aliases": [], "types": ["T044"], "canonical_name": "ryanodine receptor"}
{"concept_id": "C1753336", "aliases": [], "types": ["T044"], "canonical_name": "caffeine-sensitive calcium-release channel"}
{"concept_id": "C1753337", "aliases": ["acid sphingomyelin phosphodiesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in an acidic environment. [GOC:dph, PMID:26493087]", "canonical_name": "acid sphingomyelinase"}
{"concept_id": "C1753339", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP8B1"}
{"concept_id": "C1753340", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP5"}
{"concept_id": "C1753341", "aliases": [], "types": ["T026"], "canonical_name": "flavocytochrome b558"}
{"concept_id": "C1753345", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-15 receptor ligand"}
{"concept_id": "C1753348", "aliases": [], "types": ["T043"], "canonical_name": "nonselective vesicle exocytosis"}
{"concept_id": "C1753351", "aliases": [], "types": ["T044"], "canonical_name": "peptide:N-glycanase"}
{"concept_id": "C1753352", "aliases": [], "types": ["T044"], "canonical_name": "vitamin A receptor activity"}
{"concept_id": "C1753353", "aliases": [], "types": ["T044"], "canonical_name": "P-glycoprotein"}
{"concept_id": "C1753356", "aliases": [], "types": ["T044"], "canonical_name": "Cyp11a1"}
{"concept_id": "C1753357", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-26 receptor ligand"}
{"concept_id": "C1753358", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-25 receptor ligand"}
{"concept_id": "C1753359", "aliases": [], "types": ["T044"], "canonical_name": "insulin-like growth factor"}
{"concept_id": "C1755592", "aliases": ["type 1 fibroblast growth factor receptor ligand", "breathless ligand"], "types": ["T044"], "canonical_name": "FGFR1 ligand"}
{"concept_id": "C1755593", "aliases": [], "types": ["T044"], "canonical_name": "erythropoietin receptor ligand"}
{"concept_id": "C1755594", "aliases": [], "types": ["T044"], "canonical_name": "erythropoietin"}
{"concept_id": "C1755598", "aliases": [], "types": ["T044"], "canonical_name": "interferon-alpha/beta receptor ligand"}
{"concept_id": "C1755599", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-2 receptor ligand"}
{"concept_id": "C1755600", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-21 receptor ligand"}
{"concept_id": "C1755601", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-4 receptor ligand"}
{"concept_id": "C1755602", "aliases": [], "types": ["T044"], "canonical_name": "ARS binding"}
{"concept_id": "C1755603", "aliases": [], "types": ["T044"], "canonical_name": "bile acid-exporting ATPase activity"}
{"concept_id": "C1755604", "aliases": [], "types": ["T044"], "canonical_name": "xenobiotic ABC transporter"}
{"concept_id": "C1755605", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-24 receptor binding", "definition": "Binding to an interleukin-24 receptor. [GOC:go_curators]"}
{"concept_id": "C1755606", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-9 receptor ligand"}
{"concept_id": "C1755607", "aliases": [], "types": ["T044"], "canonical_name": "oncostatin-M receptor ligand"}
{"concept_id": "C1755608", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-1 receptor ligand"}
{"concept_id": "C1755609", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-1, type I receptor ligand"}
{"concept_id": "C1755610", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-1, type II receptor ligand"}
{"concept_id": "C1755611", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-16 receptor ligand"}
{"concept_id": "C1755612", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-18 receptor ligand"}
{"concept_id": "C1755613", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-19 receptor ligand"}
{"concept_id": "C1755614", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-20 receptor ligand"}
{"concept_id": "C1755615", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-23 receptor ligand"}
{"concept_id": "C1755616", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-8 receptor ligand"}
{"concept_id": "C1755617", "aliases": [], "types": ["T044"], "canonical_name": "neurotrophin receptor ligand"}
{"concept_id": "C1755618", "aliases": ["Ror ligand"], "types": ["T044"], "canonical_name": "receptor tyrosine kinase-like orphan receptor ligand"}
{"concept_id": "C1755619", "aliases": [], "types": ["T044"], "canonical_name": "plexin ligand"}
{"concept_id": "C1755620", "aliases": [], "types": ["T044"], "canonical_name": "semaphorin receptor ligand"}
{"concept_id": "C1755622", "aliases": ["nuclear mRNA splicing, via spliceosome"], "types": ["T045"], "canonical_name": "mRNA splicing, via spliceosome", "definition": "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. [GOC:krc, ISBN:0198506732, ISBN:0879695897]"}
{"concept_id": "C1755625", "aliases": [], "types": ["T044"], "canonical_name": "DNA damage response, activation of p53"}
{"concept_id": "C1759998", "aliases": [], "types": ["T044"], "canonical_name": "lipopolysaccharide-alpha-1,3-D-galactosyltransferase"}
{"concept_id": "C1760004", "aliases": [], "types": ["T044"], "canonical_name": "C3 photosynthesis"}
{"concept_id": "C1760008", "aliases": [], "types": ["T045"], "canonical_name": "mitotic gene conversion"}
{"concept_id": "C1760017", "aliases": [], "types": ["T043"], "canonical_name": "glycoprotein secretion"}
{"concept_id": "C1760018", "aliases": [], "types": ["T043"], "canonical_name": "protein secretion during cell fate commitment"}
{"concept_id": "C1760019", "aliases": [], "types": ["T043"], "canonical_name": "protein secretion resulting in cell fate commitment"}
{"concept_id": "C1760021", "aliases": [], "types": ["T042"], "canonical_name": "dorsal/ventral pattern specification"}
{"concept_id": "C1760025", "aliases": [], "types": ["T026"], "canonical_name": "constriction"}
{"concept_id": "C1760026", "aliases": [], "types": ["T026"], "canonical_name": "speckle focus"}
{"concept_id": "C1760028", "aliases": [], "types": ["T044"], "canonical_name": "docking protein"}
{"concept_id": "C1760029", "aliases": [], "types": ["T044"], "canonical_name": "signal recognition particle receptor"}
{"concept_id": "C1760030", "aliases": [], "types": ["T044"], "canonical_name": "vascular endothelial growth factor"}
{"concept_id": "C1760031", "aliases": [], "types": ["T044"], "canonical_name": "transforming growth factor alpha"}
{"concept_id": "C1760033", "aliases": [], "types": ["T044"], "canonical_name": "aminodeoxychorismate synthase activity"}
{"concept_id": "C1760034", "aliases": ["inner centromere core complex location"], "types": ["T026"], "canonical_name": "inner centromere core complex"}
{"concept_id": "C1760035", "aliases": [], "types": ["T026"], "canonical_name": "PA700 proteasome activator"}
{"concept_id": "C1760037", "aliases": [], "types": ["T043"], "canonical_name": "cytokinesis, contractile ring assembly"}
{"concept_id": "C1761527", "aliases": [], "types": ["T044"], "canonical_name": "pol-prim"}
{"concept_id": "C1761529", "aliases": ["GIP complex location"], "types": ["T026"], "canonical_name": "GIP complex"}
{"concept_id": "C1761530", "aliases": [], "types": ["T044"], "canonical_name": "respiratory-burst oxidase"}
{"concept_id": "C1761536", "aliases": [], "types": ["T044"], "canonical_name": "leukemia inhibitory factor receptor ligand"}
{"concept_id": "C1761537", "aliases": [], "types": ["T044"], "canonical_name": "leukemia inhibitory factor"}
{"concept_id": "C1809504", "aliases": [], "types": ["T044"], "canonical_name": "sphingolipid activator protein activity", "definition": "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase. [ISBN:0198506732]"}
{"concept_id": "C1812594", "aliases": [], "types": ["T044"], "canonical_name": "complex II (succinate to ubiquinone)"}
{"concept_id": "C1816375", "aliases": [], "types": ["T045"], "canonical_name": "telomere maintenance via recombination", "definition": "Any recombinational process that contributes to the maintenance of proper telomeric length. [GOC:elh, PMID:11850777]"}
{"concept_id": "C1816377", "aliases": [], "types": ["T043"], "canonical_name": "response to pheromone during conjugation with cellular fusion"}
{"concept_id": "C1816382", "aliases": [], "types": ["T026"], "canonical_name": "chromosome scaffold"}
{"concept_id": "C1816384", "aliases": ["septin assembly and septum biosynthesis"], "types": ["T043"], "canonical_name": "septin assembly and septum biosynthesis"}
{"concept_id": "C1816385", "aliases": [], "types": ["T045"], "canonical_name": "O6-alkylguanine-DNA alkyltransferase"}
{"concept_id": "C1816386", "aliases": ["alcohol dehydrogenase activity", "NADH-aldehyde dehydrogenase", "NADH-alcohol dehydrogenase", "NAD-specific aromatic alcohol dehydrogenase", "ADH", "alcohol:NAD+ oxidoreductase", "alcohol dehydrogenase (NAD+) activity", "NAD-dependent alcohol dehydrogenase"], "types": ["T044"], "definition": "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. [EC:1.1.1.1]", "canonical_name": "aldo-keto reductase (NAD) activity"}
{"concept_id": "C1816387", "aliases": [], "types": ["T044"], "canonical_name": "3-chloroallyl aldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. [UM-BBD_enzymeID:e0432]"}
{"concept_id": "C1816388", "aliases": [], "types": ["T044"], "canonical_name": "aldose mutarotase activity"}
{"concept_id": "C1816389", "aliases": [], "types": ["T038"], "canonical_name": "regulation of developmental process", "definition": "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:go_curators]"}
{"concept_id": "C1816391", "aliases": ["down-regulation of developmental process", "down regulation of developmental process", "downregulation of developmental process"], "types": ["T039"], "canonical_name": "negative regulation of developmental process", "definition": "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:ai]"}
{"concept_id": "C1816392", "aliases": ["up regulation of developmental process", "up-regulation of developmental process", "upregulation of developmental process"], "types": ["T039"], "canonical_name": "positive regulation of developmental process", "definition": "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:ai]"}
{"concept_id": "C1816393", "aliases": [], "types": ["T042"], "canonical_name": "cholinergic synaptogenesis"}
{"concept_id": "C1816396", "aliases": [], "types": ["T038"], "canonical_name": "regulation of multicellular organismal process", "definition": "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C1816397", "aliases": ["upregulation of multicellular organismal process", "up-regulation of multicellular organismal process", "up regulation of multicellular organismal process"], "types": ["T039"], "canonical_name": "positive regulation of multicellular organismal process", "definition": "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. [GOC:ai]"}
{"concept_id": "C1816398", "aliases": ["downregulation of multicellular organismal process", "down regulation of multicellular organismal process", "down-regulation of multicellular organismal process"], "types": ["T039"], "canonical_name": "negative regulation of multicellular organismal process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. [GOC:ai]"}
{"concept_id": "C1816400", "aliases": ["terpene biosynthetic process, mevalonate-independent"], "types": ["T044"], "canonical_name": "mevalonate-independent terpene biosynthetic process"}
{"concept_id": "C1816401", "aliases": [], "types": ["T044"], "canonical_name": "terpene biosynthetic process, mevalonate-dependent"}
{"concept_id": "C1816402", "aliases": [], "types": ["T044"], "canonical_name": "elastin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries. [GOC:ai]"}
{"concept_id": "C1816403", "aliases": [], "types": ["T043"], "canonical_name": "regulation of elastin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin. [GOC:ai]"}
{"concept_id": "C1816404", "aliases": ["upregulation of elastin biosynthetic process", "up-regulation of elastin biosynthetic process", "up regulation of elastin biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of elastin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin. [GOC:ai]"}
{"concept_id": "C1816405", "aliases": ["down regulation of elastin biosynthetic process", "down-regulation of elastin biosynthetic process", "downregulation of elastin biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of elastin biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin. [GOC:ai]"}
{"concept_id": "C1816406", "aliases": [], "types": ["T044"], "canonical_name": "2-phenyl-4H-1-benzopyran-4-one metabolic process"}
{"concept_id": "C1816407", "aliases": [], "types": ["T044"], "canonical_name": "2-phenylchromone metabolic process"}
{"concept_id": "C1816408", "aliases": [], "types": ["T044"], "canonical_name": "flavone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). [GOC:ai, PMID:18567791]"}
{"concept_id": "C1816409", "aliases": ["2-phenylchromone biosynthetic process"], "types": ["T044"], "canonical_name": "2-phenyl-4H-1-benzopyran-4-one biosynthetic process"}
{"concept_id": "C1816410", "aliases": [], "types": ["T044"], "canonical_name": "flavonol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities. [GOC:ai]"}
{"concept_id": "C1816411", "aliases": [], "types": ["T044"], "canonical_name": "leucoanthocyanidin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids. [GOC:ai]"}
{"concept_id": "C1816412", "aliases": [], "types": ["T044"], "canonical_name": "phlobaphene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols. [PMID:11402179]"}
{"concept_id": "C1816414", "aliases": [], "types": ["T044"], "canonical_name": "pullulan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. [GOC:ai]"}
{"concept_id": "C1816415", "aliases": [], "types": ["T044"], "canonical_name": "pullulan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. [GOC:ai]"}
{"concept_id": "C1816416", "aliases": [], "types": ["T043"], "canonical_name": "galactomannan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units. [GOC:ai]"}
{"concept_id": "C1816417", "aliases": [], "types": ["T044"], "canonical_name": "sesquiterpene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. [GOC:ai]"}
{"concept_id": "C1816418", "aliases": [], "types": ["T044"], "canonical_name": "sesquiterpene synthase activity", "definition": "Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons. [EC:4.2.3.-, GOC:tair_curators]"}
{"concept_id": "C1816419", "aliases": [], "types": ["T038"], "canonical_name": "regulation of hair follicle development", "definition": "Any process that modulates the frequency, rate or extent of hair follicle development. [GOC:ai]"}
{"concept_id": "C1816420", "aliases": ["up-regulation of hair follicle development", "upregulation of hair follicle development", "up regulation of hair follicle development"], "types": ["T039"], "canonical_name": "positive regulation of hair follicle development", "definition": "Any process that activates or increases the frequency, rate or extent of hair follicle development. [GOC:ai]"}
{"concept_id": "C1816421", "aliases": ["down-regulation of hair follicle development", "downregulation of hair follicle development", "down regulation of hair follicle development"], "types": ["T039"], "canonical_name": "negative regulation of hair follicle development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development. [GOC:ai]"}
{"concept_id": "C1816422", "aliases": [], "types": ["T040"], "canonical_name": "active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction"}
{"concept_id": "C1816423", "aliases": [], "types": ["T040"], "canonical_name": "regulation of morphology of other organism"}
{"concept_id": "C1816425", "aliases": [], "types": ["T040"], "canonical_name": "regulation of physiology of other organism"}
{"concept_id": "C1816429", "aliases": [], "types": ["T043"], "canonical_name": "cytolysis by host of symbiont cells", "definition": "The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:add]"}
{"concept_id": "C1816430", "aliases": [], "types": ["T040"], "canonical_name": "regulation by host of cytolysis of symbiont cells", "definition": "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:add]"}
{"concept_id": "C1816431", "aliases": ["down regulation by host of cytolysis of symbiont cells", "down-regulation by host of cytolysis of symbiont cells", "downregulation by host of cytolysis of symbiont cells"], "types": ["T043"], "canonical_name": "negative regulation by host of cytolysis of symbiont cells", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:add]"}
{"concept_id": "C1816432", "aliases": ["upregulation by host of cytolysis of symbiont cells", "up-regulation by host of cytolysis of symbiont cells", "up regulation by host of cytolysis of symbiont cells"], "types": ["T043"], "canonical_name": "positive regulation by host of cytolysis of symbiont cells", "definition": "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:add]"}
{"concept_id": "C1816434", "aliases": [], "types": ["T043"], "canonical_name": "disruption by host of symbiont cells"}
{"concept_id": "C1816437", "aliases": ["histone demethylase activity (H3-K36 specific)", "histone-lysine(H3-K36) demethylase activity", "histone-lysine demethylase activity (H3-K36 specific)", "[histone-H3]-lysine-36 demethylase activity", "histone-lysine (H3-K36) demethylase activity", "histone H3-lysine-36 demethylase activity"], "types": ["T044"], "canonical_name": "histone H3-methyl-lysine-36 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:16362057]"}
{"concept_id": "C1816438", "aliases": ["protein self-ubiquitinylation", "protein autoubiquitinylation", "protein auto-ubiquitinylation", "protein self-ubiquitination", "protein auto-ubiquitination"], "types": ["T044"], "canonical_name": "protein autoubiquitination", "definition": "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. [GOC:ai]"}
{"concept_id": "C1816439", "aliases": ["general adaptation syndrome, behavioral response", "behavioral process during general adaptation syndrome", "general adaptation syndrome, behavioural response", "general adaptation syndrome, behavioural process", "behavioural process during general adaptation syndrome", "behavioral response during general adaptation syndrome", "behavioural response during general adaptation syndrome"], "types": ["T055"], "canonical_name": "general adaptation syndrome, behavioral process", "definition": "The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus. [GOC:ai]"}
{"concept_id": "C1816440", "aliases": [], "types": ["T044"], "canonical_name": "methotrexate binding", "definition": "Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. [GOC:nln]"}
{"concept_id": "C1816441", "aliases": ["DHF binding", "dihydrofolate binding"], "types": ["T044"], "canonical_name": "dihydrofolic acid binding", "definition": "Binding to dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms. [ISBN:0721662544]"}
{"concept_id": "C1816442", "aliases": ["sphing-4-enine catabolic process", "(4E)-sphing-4-enine catabolism", "sphing-4-enine catabolism", "(4E)-sphing-4-enine catabolic process"], "types": ["T044"], "canonical_name": "sphingosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. [GOC:ai]"}
{"concept_id": "C1816443", "aliases": [], "types": ["T043"], "canonical_name": "killing by host of symbiont cells", "definition": "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:add]"}
{"concept_id": "C1816444", "aliases": ["dihydrosphingosine-1-phosphate catabolism", "dihydrosphingosine-1-phosphate catabolic process"], "types": ["T044"], "canonical_name": "sphinganine-1-phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. [GOC:ai]"}
{"concept_id": "C1816445", "aliases": ["pigment granule localisation"], "types": ["T038"], "canonical_name": "pigment granule localization", "definition": "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]"}
{"concept_id": "C1816446", "aliases": [], "types": ["T043"], "canonical_name": "pigment granule dispersal", "definition": "The directed movement of pigment granules within a cell towards the cell periphery. [GOC:mh]"}
{"concept_id": "C1816447", "aliases": [], "types": ["T043"], "canonical_name": "pigment granule aggregation in cell center", "definition": "The directed movement of dispersed pigment granules towards the center of the cell. [GOC:mh]"}
{"concept_id": "C1816448", "aliases": [], "types": ["T043"], "canonical_name": "lateral element assembly", "definition": "The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements. [PMID:11463847]"}
{"concept_id": "C1816449", "aliases": ["Hsp90 class protein binding", "Hsp90 binding"], "types": ["T044"], "canonical_name": "Hsp90 protein binding", "definition": "Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. [GOC:ai]"}
{"concept_id": "C1816450", "aliases": ["G-quartet DNA binding", "G-quartet binding", "G-DNA binding", "G quadruplex DNA binding", "G quartet DNA binding", "quadruplex DNA binding", "G-quadruplex DNA binding", "G quartet binding"], "types": ["T045"], "definition": "Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. [PMID:16142245, PMID:9512530]", "canonical_name": "tetraplex DNA binding"}
{"concept_id": "C1816451", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial membrane potential", "definition": "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:ai]"}
{"concept_id": "C1816452", "aliases": ["mitochondrial depolarisation", "mitochondrial membrane depolarization", "mitochondria depolarization", "mitochondrion depolarization"], "types": ["T043"], "canonical_name": "mitochondrial depolarization", "definition": "The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level. [Wikipedia:Depolarization, Wikipedia:Mitochondrion]"}
{"concept_id": "C1816453", "aliases": [], "types": ["T043"], "canonical_name": "membrane depolarization", "definition": "The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dh, Wikipedia:Depolarization]"}
{"concept_id": "C1816454", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial depolarization", "definition": "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. [GOC:ai]"}
{"concept_id": "C1816455", "aliases": ["up regulation of mitochondrial depolarization", "up-regulation of mitochondrial depolarization", "upregulation of mitochondrial depolarization"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial depolarization", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. [GOC:ai]"}
{"concept_id": "C1816456", "aliases": ["down regulation of mitochondrial depolarization", "down-regulation of mitochondrial depolarization", "downregulation of mitochondrial depolarization"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial depolarization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. [GOC:ai]"}
{"concept_id": "C1816457", "aliases": ["GS-FDH activity", "NAD-linked formaldehyde dehydrogenase activity", "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity", "GD-FALDH activity", "NAD-dependent formaldehyde dehydrogenase activity", "NAD- and glutathione-dependent formaldehyde dehydrogenase activity", "glutathione-dependent formaldehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "S-(hydroxymethyl)glutathione dehydrogenase activity", "definition": "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. [EC:1.1.1.284]"}
{"concept_id": "C1816458", "aliases": ["pigment granule translocation"], "types": ["T043"], "canonical_name": "pigment granule transport", "definition": "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816459", "aliases": ["establishment of pigment granule localisation"], "types": ["T043"], "canonical_name": "establishment of pigment granule localization", "definition": "The directed movement of a pigment granule to a specific location. [GOC:ai]"}
{"concept_id": "C1816460", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of pigment granule localization"}
{"concept_id": "C1816461", "aliases": ["S-(hydroxymethyl)glutathione formaldehyde-lyase activity", "glutathione-dependent formaldehyde-activating enzyme activity", "Gfa", "S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione. [EC:4.4.1.22, RHEA:22488]", "canonical_name": "S-(hydroxymethyl)glutathione synthase activity"}
{"concept_id": "C1816462", "aliases": ["double-stranded DNA specific 5'-3' exodeoxyribonuclease activity"], "types": ["T045"], "canonical_name": "double-stranded DNA 5'-3' exodeoxyribonuclease activity", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule. [GOC:ai]"}
{"concept_id": "C1816463", "aliases": ["3-hydroxypropenoate dehydratase activity"], "types": ["T044"], "canonical_name": "acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate", "definition": "Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O. [MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN]"}
{"concept_id": "C1816464", "aliases": ["hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity", "methylviologen-reducing hydrogenase activity", "methanophenazine hydrogenase activity"], "types": ["T044"], "canonical_name": "Methanosarcina-phenazine hydrogenase activity", "definition": "Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine. [EC:1.12.98.3]"}
{"concept_id": "C1816465", "aliases": ["coenzyme B:coenzyme M:methanophenazine oxidoreductase activity", "coenzyme B--coenzyme M heterodisulfide reductase activity", "CoB-CoM heterodisulfide reductase activity"], "types": ["T044"], "canonical_name": "CoB--CoM heterodisulfide reductase activity", "definition": "Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine. [RHEA:18085]"}
{"concept_id": "C1816467", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic plasticity by chemical substance", "definition": "The process in which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require. [GOC:ai]"}
{"concept_id": "C1816468", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic plasticity by drug"}
{"concept_id": "C1816469", "aliases": ["up-regulation of synaptic plasticity by chemical substance", "upregulation of synaptic plasticity by chemical substance", "up regulation of synaptic plasticity by chemical substance"], "types": ["T042"], "canonical_name": "positive regulation of synaptic plasticity by chemical substance", "definition": "The process in which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require. [GOC:ai]"}
{"concept_id": "C1816470", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of synaptic plasticity by drug"}
{"concept_id": "C1816471", "aliases": ["activation of synaptic plasticity by chemical substance"], "types": ["T042"], "canonical_name": "induction of synaptic plasticity by chemical substance", "definition": "The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require. [GOC:ai]"}
{"concept_id": "C1816472", "aliases": [], "types": ["T042"], "canonical_name": "activation of synaptic plasticity by drug"}
{"concept_id": "C1816473", "aliases": [], "types": ["T042"], "canonical_name": "induction of synaptic plasticity by drug"}
{"concept_id": "C1816474", "aliases": [], "types": ["T042"], "canonical_name": "regulation of fibrinolysis", "definition": "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. [GOC:ai]"}
{"concept_id": "C1816475", "aliases": ["downregulation of fibrinolysis", "down-regulation of fibrinolysis", "down regulation of fibrinolysis"], "types": ["T042"], "canonical_name": "negative regulation of fibrinolysis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. [GOC:ai]"}
{"concept_id": "C1816476", "aliases": ["up-regulation of fibrinolysis", "upregulation of fibrinolysis", "up regulation of fibrinolysis"], "types": ["T042"], "canonical_name": "positive regulation of fibrinolysis", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. [GOC:ai]"}
{"concept_id": "C1816477", "aliases": ["PRDX activity", "Prx activity"], "types": ["T044"], "canonical_name": "peroxiredoxin activity", "definition": "Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. [RHEA:10008]"}
{"concept_id": "C1816478", "aliases": [], "types": ["T044"], "canonical_name": "AhpC activity"}
{"concept_id": "C1816479", "aliases": [], "types": ["T044"], "canonical_name": "alkyl hydroperoxide reductase C22 activity"}
{"concept_id": "C1816480", "aliases": ["TXNPx activity"], "types": ["T044"], "canonical_name": "tryparedoxin peroxidase activity", "definition": "Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O. [GOC:mah, PMID:32388269]"}
{"concept_id": "C1816482", "aliases": ["Ado-cobyric acid synthase [glutamine hydrolyzing] activity", "adenosylcobyric acid synthase (glutamine-hydrolysing) activity", "adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)", "5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity"], "types": ["T044"], "canonical_name": "adenosylcobyric acid synthase (glutamine-hydrolyzing) activity", "definition": "Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H(2)O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H(+) + 4 phosphate. [EC:6.3.5.10, RHEA:23256]"}
{"concept_id": "C1816483", "aliases": [], "types": ["T044"], "canonical_name": "CobQ activity"}
{"concept_id": "C1816484", "aliases": [], "types": ["T044"], "canonical_name": "cobyric acid synthase activity"}
{"concept_id": "C1816485", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate. [PMID:12730293]"}
{"concept_id": "C1816486", "aliases": ["regulation of calcium transport"], "types": ["T043"], "canonical_name": "regulation of calcium ion transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816488", "aliases": ["down regulation of calcium ion transport", "down-regulation of calcium ion transport", "negative regulation of calcium transport", "downregulation of calcium ion transport"], "types": ["T043"], "canonical_name": "negative regulation of calcium ion transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816490", "aliases": ["positive regulation of calcium transport", "up-regulation of calcium ion transport", "upregulation of calcium ion transport", "up regulation of calcium ion transport"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816492", "aliases": [], "types": ["T038"], "canonical_name": "regulation of sensory perception of pain", "definition": "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. [GOC:ai]"}
{"concept_id": "C1816493", "aliases": [], "types": ["T040"], "canonical_name": "regulation of sensory perception", "definition": "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. [GOC:ai]"}
{"concept_id": "C1816494", "aliases": ["synaptic transmission, gamma-aminobutyric acid-ergic", "GABAergic synaptic transmission", "synaptic transmission, gamma-aminobutyric acid mediated", "synaptic transmission, GABA mediated"], "types": ["T043"], "canonical_name": "synaptic transmission, GABAergic", "definition": "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, ISBN:0126603030]"}
{"concept_id": "C1816495", "aliases": [], "types": ["T043"], "canonical_name": "amino acid neurotransmitter reuptake", "definition": "The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]"}
{"concept_id": "C1816496", "aliases": [], "types": ["T043"], "canonical_name": "amino acid neurotransmitter import into glial cell"}
{"concept_id": "C1816497", "aliases": [], "types": ["T043"], "canonical_name": "amino acid neurotransmitter import into neuron"}
{"concept_id": "C1816498", "aliases": [], "types": ["T043"], "canonical_name": "amino acid neurotransmitter recycling"}
{"concept_id": "C1816499", "aliases": ["catecholamine neurotransmitter reuptake"], "types": ["T043"], "canonical_name": "catecholamine uptake involved in synaptic transmission", "definition": "The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]"}
{"concept_id": "C1816500", "aliases": [], "types": ["T043"], "canonical_name": "catecholamine neurotransmitter import into glial cell"}
{"concept_id": "C1816501", "aliases": [], "types": ["T043"], "canonical_name": "catecholamine neurotransmitter import into neuron"}
{"concept_id": "C1816502", "aliases": [], "types": ["T043"], "canonical_name": "catecholamine neurotransmitter recycling"}
{"concept_id": "C1816503", "aliases": ["L-glutamate uptake involved in synaptic transmission", "L-glutamate reuptake"], "types": ["T043"], "canonical_name": "glutamate reuptake", "definition": "The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387, Wikipedia:Glutamate_transporter]"}
{"concept_id": "C1816504", "aliases": [], "types": ["T043"], "canonical_name": "glutamate import into glial cell"}
{"concept_id": "C1816505", "aliases": [], "types": ["T043"], "canonical_name": "glutamate import into neuron"}
{"concept_id": "C1816506", "aliases": [], "types": ["T043"], "canonical_name": "glutamate recycling"}
{"concept_id": "C1816507", "aliases": ["gamma-aminobutyric acid uptake involved in synaptic transmission", "GABA reuptake"], "types": ["T043"], "canonical_name": "gamma-aminobutyric acid reuptake", "definition": "The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]"}
{"concept_id": "C1816511", "aliases": ["GABA import into glial cell"], "types": ["T043"], "canonical_name": "gamma-aminobutyric acid import into glial cell"}
{"concept_id": "C1816512", "aliases": ["GABA import into neuron"], "types": ["T043"], "canonical_name": "gamma-aminobutyric acid import into neuron"}
{"concept_id": "C1816513", "aliases": ["GABA recycling"], "types": ["T043"], "canonical_name": "gamma-aminobutyric acid recycling"}
{"concept_id": "C1816514", "aliases": [], "types": ["T043"], "canonical_name": "catecholamine transport", "definition": "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C1816515", "aliases": ["L-glutamate uptake"], "types": ["T043"], "canonical_name": "L-glutamate import", "definition": "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle. [GOC:ai, GOC:jsg, GOC:mah]"}
{"concept_id": "C1816516", "aliases": ["GABA import", "gamma-aminobutyric acid uptake", "4-aminobutyrate import", "gamma-aminobutyrate import"], "types": ["T043"], "canonical_name": "gamma-aminobutyric acid import", "definition": "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle. [GOC:ai]"}
{"concept_id": "C1816517", "aliases": ["regulation of catecholamine neurotransmitter uptake", "regulation of catecholamine neurotransmitter reuptake"], "types": ["T043"], "canonical_name": "regulation of catecholamine uptake involved in synaptic transmission", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C1816518", "aliases": ["regulation of amino acid neurotransmitter reuptake", "regulation of amino acid neurotransmitter uptake"], "types": ["T043"], "canonical_name": "regulation of amino acid uptake involved in synaptic transmission", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C1816519", "aliases": ["negative regulation of amino acid neurotransmitter uptake", "negative regulation of amino acid neurotransmitter reuptake"], "types": ["T043"], "canonical_name": "negative regulation of amino acid uptake involved in synaptic transmission", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C1816520", "aliases": ["positive regulation of amino acid neurotransmitter uptake", "positive regulation of amino acid neurotransmitter reuptake"], "types": ["T043"], "canonical_name": "positive regulation of amino acid uptake involved in synaptic transmission", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C1816523", "aliases": ["regulation of L-glutamate uptake during transmission of nerve impulse", "regulation of L-glutamate reuptake", "regulation of glutamate uptake involved in conduction of nerve impulse", "regulation of glutamate reuptake"], "types": ["T043"], "canonical_name": "regulation of glutamate uptake involved in transmission of nerve impulse", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C1816524", "aliases": ["regulation of GABA uptake during transmission of nerve impulse", "regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse", "regulation of gamma-aminobutyric acid reuptake", "regulation of 4-aminobutyrate uptake during transmission of nerve impulse", "regulation of GABA reuptake", "regulation of 4-aminobutyrate reuptake"], "types": ["T043"], "canonical_name": "regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C1816529", "aliases": [], "types": ["T044"], "canonical_name": "regulation of amine transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816530", "aliases": ["downregulation of amine transport", "down-regulation of amine transport", "down regulation of amine transport"], "types": ["T044"], "canonical_name": "negative regulation of amine transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816531", "aliases": ["upregulation of amine transport", "up-regulation of amine transport", "up regulation of amine transport"], "types": ["T044"], "canonical_name": "positive regulation of amine transport", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816532", "aliases": [], "types": ["T044"], "canonical_name": "regulation of amino acid transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816533", "aliases": ["negative regulation of amino acid transmembrane transport", "down regulation of amino acid transport", "down-regulation of amino acid transport", "downregulation of amino acid transport"], "types": ["T044"], "canonical_name": "negative regulation of amino acid transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816534", "aliases": ["up regulation of amino acid transport", "upregulation of amino acid transport", "positive regulation of amino acid transmembrane transport", "up-regulation of amino acid transport"], "types": ["T044"], "canonical_name": "positive regulation of amino acid transport", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1816535", "aliases": [], "types": ["T043"], "canonical_name": "methotrexate transport", "definition": "The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. [GOC:ai]"}
{"concept_id": "C1816536", "aliases": [], "types": ["T044"], "canonical_name": "dynein light intermediate chain binding", "definition": "Binding to a light intermediate chain of the dynein complex. [GOC:bf]"}
{"concept_id": "C1816537", "aliases": [], "types": ["T038"], "canonical_name": "regulation of nervous system development", "definition": "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. [GOC:ai]"}
{"concept_id": "C1816538", "aliases": ["down-regulation of nervous system development", "downregulation of nervous system development", "down regulation of nervous system development"], "types": ["T039"], "canonical_name": "negative regulation of nervous system development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. [GOC:ai]"}
{"concept_id": "C1816539", "aliases": ["up-regulation of nervous system development", "upregulation of nervous system development", "up regulation of nervous system development"], "types": ["T039"], "canonical_name": "positive regulation of nervous system development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. [GOC:ai]"}
{"concept_id": "C1816540", "aliases": ["regulation of synaptogenesis", "regulation of synapse biogenesis"], "types": ["T038"], "canonical_name": "regulation of synapse assembly", "definition": "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]"}
{"concept_id": "C1816541", "aliases": ["down regulation of synapse assembly", "down-regulation of synapse assembly", "negative regulation of synapse biogenesis", "negative regulation of synaptogenesis", "downregulation of synapse assembly"], "types": ["T038"], "canonical_name": "negative regulation of synapse assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]"}
{"concept_id": "C1816542", "aliases": ["positive regulation of synaptogenesis", "stimulation of synapse assembly", "up-regulation of synapse assembly", "activation of synapse assembly", "upregulation of synapse assembly", "positive regulation of synapse biogenesis", "up regulation of synapse assembly"], "types": ["T043"], "canonical_name": "positive regulation of synapse assembly", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]"}
{"concept_id": "C1816543", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic transmission, glutamatergic", "definition": "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]"}
{"concept_id": "C1816544", "aliases": ["down-regulation of synaptic transmission, glutamatergic", "down regulation of synaptic transmission, glutamatergic", "downregulation of synaptic transmission, glutamatergic"], "types": ["T042"], "canonical_name": "negative regulation of synaptic transmission, glutamatergic", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]"}
{"concept_id": "C1816545", "aliases": ["up-regulation of synaptic transmission, glutamatergic", "up regulation of synaptic transmission, glutamatergic", "upregulation of synaptic transmission, glutamatergic"], "types": ["T042"], "canonical_name": "positive regulation of synaptic transmission, glutamatergic", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]"}
{"concept_id": "C1816546", "aliases": ["regulation of conduction of nerve impulse"], "types": ["T040"], "canonical_name": "regulation of transmission of nerve impulse", "definition": "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]"}
{"concept_id": "C1816547", "aliases": ["down-regulation of transmission of nerve impulse", "negative regulation of conduction of nerve impulse", "down regulation of transmission of nerve impulse", "downregulation of transmission of nerve impulse"], "types": ["T040"], "canonical_name": "negative regulation of transmission of nerve impulse", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]"}
{"concept_id": "C1816548", "aliases": ["upregulation of transmission of nerve impulse", "up regulation of transmission of nerve impulse", "up-regulation of transmission of nerve impulse", "positive regulation of conduction of nerve impulse"], "types": ["T040"], "canonical_name": "positive regulation of transmission of nerve impulse", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]"}
{"concept_id": "C1816549", "aliases": ["telomerase regulator"], "types": ["T044"], "canonical_name": "regulation of telomerase activity", "definition": "Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. [EC:2.-.-.-, GOC:ai]"}
{"concept_id": "C1816550", "aliases": ["up regulation of telomerase activity", "up-regulation of telomerase activity", "upregulation of telomerase activity"], "types": ["T044"], "canonical_name": "positive regulation of telomerase activity", "definition": "Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). [GOC:ai]"}
{"concept_id": "C1816551", "aliases": [], "types": ["T044"], "canonical_name": "telomerase activator"}
{"concept_id": "C1816552", "aliases": ["down-regulation of telomerase activity", "downregulation of telomerase activity", "down regulation of telomerase activity"], "types": ["T044"], "canonical_name": "negative regulation of telomerase activity", "definition": "Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). [GOC:ai]"}
{"concept_id": "C1816553", "aliases": ["telomerase inhibitor activity"], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of telomerase. [GOC:dph, GOC:krc, GOC:tb]", "canonical_name": "telomerase inhibitor"}
{"concept_id": "C1816554", "aliases": ["lysine biosynthetic process via aminoadipic acid and saccharopine", "lysine biosynthesis via aminoadipic acid and saccharopine"], "types": ["T044"], "canonical_name": "lysine biosynthetic process via alpha-aminoadipate and saccharopine", "definition": "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine. [MetaCyc:LYSINE-AMINOAD-PWY]"}
{"concept_id": "C1816555", "aliases": ["lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate", "lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate"], "types": ["T044"], "canonical_name": "lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate", "definition": "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine. [MetaCyc:PWY-3081]"}
{"concept_id": "C1816556", "aliases": [], "types": ["T043"], "canonical_name": "lysophospholipid transport", "definition": "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids. [GOC:ai]"}
{"concept_id": "C1816557", "aliases": [], "types": ["T044"], "canonical_name": "lysophospholipid transporter activity"}
{"concept_id": "C1816558", "aliases": ["alginate acetylation"], "types": ["T044"], "canonical_name": "alginic acid acetylation", "definition": "The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate. [GOC:mlg]"}
{"concept_id": "C1816559", "aliases": ["Fe-NA chelate transporter activity"], "types": ["T044"], "canonical_name": "iron-nicotianamine transmembrane transporter activity", "definition": "Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other. [GOC:ai, PMID:20625001]"}
{"concept_id": "C1816560", "aliases": [], "types": ["T044"], "canonical_name": "copper chelate transmembrane transporter activity", "definition": "Enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions. [PMID:26512647]"}
{"concept_id": "C1816561", "aliases": ["Cu-NA chelate transporter activity"], "types": ["T044"], "canonical_name": "copper-nicotianamine transmembrane transporter activity", "definition": "Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C1816562", "aliases": [], "types": ["T045"], "canonical_name": "regulation of chromosome segregation", "definition": "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. [GOC:ai]"}
{"concept_id": "C1816563", "aliases": ["up regulation of chromosome segregation", "up-regulation of chromosome segregation", "upregulation of chromosome segregation"], "types": ["T045"], "canonical_name": "positive regulation of chromosome segregation", "definition": "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. [GOC:ai]"}
{"concept_id": "C1816564", "aliases": ["down regulation of chromosome segregation", "downregulation of chromosome segregation", "down-regulation of chromosome segregation"], "types": ["T045"], "canonical_name": "negative regulation of chromosome segregation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. [GOC:ai]"}
{"concept_id": "C1816565", "aliases": ["downregulation of attachment of spindle microtubules to kinetochore", "down regulation of attachment of spindle microtubules to kinetochore", "down-regulation of attachment of spindle microtubules to kinetochore"], "types": ["T043"], "canonical_name": "negative regulation of attachment of spindle microtubules to kinetochore", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. [GOC:ai]"}
{"concept_id": "C1816566", "aliases": ["upregulation of attachment of spindle microtubules to kinetochore", "up-regulation of attachment of spindle microtubules to kinetochore", "up regulation of attachment of spindle microtubules to kinetochore"], "types": ["T043"], "canonical_name": "positive regulation of attachment of spindle microtubules to kinetochore", "definition": "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. [GOC:ai]"}
{"concept_id": "C1816567", "aliases": ["regulation of kinetochore-microtubule attachment"], "types": ["T043"], "canonical_name": "regulation of attachment of spindle microtubules to kinetochore", "definition": "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. [GOC:ai]"}
{"concept_id": "C1816569", "aliases": ["D-2-hydroxyglutarate dehydrogenase activity"], "types": ["T044"], "canonical_name": "(R)-2-hydroxyglutarate dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. [EC:1.1.99.39, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]"}
{"concept_id": "C1816570", "aliases": [], "types": ["T043"], "canonical_name": "type IV pili-dependent aggregation"}
{"concept_id": "C1816571", "aliases": [], "types": ["T043"], "canonical_name": "auto-aggregation"}
{"concept_id": "C1816572", "aliases": [], "types": ["T040"], "canonical_name": "type IV pili-dependent localized adherence to host", "definition": "Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:ml]"}
{"concept_id": "C1816574", "aliases": ["down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "negative modulation by organism of defense-related host SA-mediated signal transduction pathway", "negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "negative regulation of host SA-mediated defense response", "suppression of host SA mediated defense response", "downregulation by symbiont of host salicylic acid-mediated defense response", "downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway", "down regulation by symbiont of host salicylic acid-mediated defense response", "suppression by organism of host salicylic acid-mediated defense response", "down-regulation by symbiont of host salicylic acid-mediated defense response", "negative regulation by symbiont of host salicylic acid-mediated defense response", "negative regulation by organism of defense-related host SA-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "suppression by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816576", "aliases": ["down regulation by symbiont of host ethylene-mediated defense response", "down-regulation by symbiont of host ethylene-mediated defense response", "negative regulation by symbiont of host ethylene-mediated defense response", "suppression by organism of host ethylene-mediated defense response", "downregulation by symbiont of host ethylene-mediated defense response"], "types": ["T040"], "canonical_name": "suppression by symbiont of host ethylene-mediated defense response", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816579", "aliases": ["disassembly by organism of host cellular component", "catabolism of host structural constituent by organism", "degradation of host cellular component by organism", "disassembly by symbiont of host cellular component", "catabolism of host cellular component by organism"], "types": ["T040"], "canonical_name": "disruption by symbiont of host cellular component", "definition": "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [ISBN:0198547684]"}
{"concept_id": "C1816580", "aliases": ["disassembly by symbiont of host cell wall", "disruption by symbiont of host cell envelope"], "types": ["T040"], "canonical_name": "disruption by symbiont of host cell wall", "definition": "A process carried out by a symbiont that breaks down the cell wall of its host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [ISBN:0198547684]"}
{"concept_id": "C1816589", "aliases": ["modulation by symbiont of host RNA levels"], "types": ["T040"], "canonical_name": "modulation by symbiont of RNA levels in host", "definition": "The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816590", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host hormone or growth regulator levels", "definition": "The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816591", "aliases": ["metabolism of host cell wall by organism"], "types": ["T040"], "canonical_name": "modification by symbiont of host cell wall", "definition": "The process in which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. [ISBN:0198547684]"}
{"concept_id": "C1816592", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of ethylene levels in host", "definition": "The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816593", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of jasmonic acid levels in host", "definition": "The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816594", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of salicylic acid levels in host", "definition": "The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816595", "aliases": ["positive modulation of hormone or growth regulator levels in host", "up regulation by symbiont of hormone or growth regulator levels in host", "up-regulation by symbiont of hormone or growth regulator levels in host", "upregulation by symbiont of hormone or growth regulator levels in host"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of hormone or growth regulator levels in host", "definition": "The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816596", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host cell membrane", "definition": "The process in which an organism effects a change in the structure or function of a host cellular membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816597", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host transcription", "definition": "Any process in which an organism modulates the frequency, rate or extent of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816598", "aliases": ["regulation by symbiont of host signal transduction pathway", "modulation by symbiont of host signal transduction", "modulation of host signal transduction by symbiont"], "types": ["T040"], "canonical_name": "modulation by symbiont of host signal transduction pathway", "definition": "Any process in which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816599", "aliases": ["up regulation by symbiont of host signal transduction pathway", "up-regulation by symbiont of host signal transduction pathway", "upregulation by symbiont of host signal transduction pathway", "positive regulation by symbiont of host signal transduction pathway"], "types": ["T040"], "canonical_name": "induction by symbiont of host signal transduction pathway", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816600", "aliases": ["negative modulation by organism of host signal transduction pathway", "downregulation by symbiont of host signal transduction pathway", "down regulation by symbiont of host signal transduction pathway", "down-regulation by symbiont of host signal transduction pathway", "negative regulation by symbiont of host signal transduction pathway"], "types": ["T040"], "canonical_name": "suppression by symbiont of host signal transduction pathway", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816602", "aliases": ["mitigation by symbiont of host defense response"], "types": ["T040"], "canonical_name": "modulation by symbiont of host defense response", "definition": "Any process in which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816603", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host inflammatory response", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816606", "aliases": ["up-regulation by symbiont of host inflammatory response", "upregulation by symbiont of host inflammatory response", "up regulation by symbiont of host inflammatory response"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host inflammatory response", "definition": "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816607", "aliases": ["negative regulation by symbiont of host inflammatory response", "downregulation by symbiont of host inflammatory response", "down-regulation by symbiont of host inflammatory response", "down regulation by symbiont of host inflammatory response"], "types": ["T040"], "canonical_name": "suppression by symbiont of host inflammatory response", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816609", "aliases": ["modulation of host intracellular trafficking"], "types": ["T040"], "canonical_name": "modulation by symbiont of host intracellular transport", "definition": "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816610", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host cytoskeleton"}
{"concept_id": "C1816611", "aliases": ["modulation of host PCD"], "types": ["T040"], "canonical_name": "modulation by symbiont of host programmed cell death", "definition": "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816613", "aliases": ["inhibition of host programmed cell death", "down regulation by symbiont of host programmed cell death", "suppression by symbiont of host PCD", "suppression by symbiont of host programmed cell death", "downregulation by symbiont of host programmed cell death", "down-regulation by symbiont of host programmed cell death"], "types": ["T040"], "canonical_name": "negative regulation by symbiont of host programmed cell death", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816614", "aliases": ["induction by organism of programmed cell death in other organism involved in symbiotic interaction", "enhancement of host programmed cell death by organism", "activation by organism of programmed cell death in other organism during symbiotic interaction", "enhancement of host programmed cell death", "upregulation by symbiont of host programmed cell death", "induction by symbiont of host programmed cell death", "activation by organism of host programmed cell death"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host programmed cell death", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:jl, GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816615", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host cellular component", "definition": "The process in which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816626", "aliases": ["down-regulation by symbiont of host enzyme activity", "down regulation by symbiont of host enzyme activity", "downregulation by symbiont of host enzyme activity", "inhibition of host enzyme activity", "negative regulation by symbiont of host enzyme activity"], "types": ["T040"], "canonical_name": "negative regulation by symbiont of host catalytic activity", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816628", "aliases": ["modification by symbiont of host protein function", "modification by symbiont of host molecular function"], "types": ["T040"], "canonical_name": "modulation by symbiont of host molecular function", "definition": "The process in which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]"}
{"concept_id": "C1816629", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of host protein function"}
{"concept_id": "C1816635", "aliases": ["evasion or tolerance by symbiont of host-produced phytoalexins", "evasion or tolerance of phytoalexins produced by host in response to organism", "evasion or tolerance of phytoalexins"], "types": ["T040"], "canonical_name": "symbiont defense to host-produced phytoalexin", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816636", "aliases": [], "types": ["T040"], "canonical_name": "host phytoalexin detoxification"}
{"concept_id": "C1816637", "aliases": ["activation by organism of host phytoalexin production"], "types": ["T040"], "canonical_name": "induction by symbiont of host phytoalexin production", "definition": "The activation by a symbiont of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816638", "aliases": ["induction by organism of defense-related host NO production", "activation by organism of defense-related host nitric oxide production", "activation by organism of defense-related host NO production"], "types": ["T043"], "canonical_name": "induction by symbiont of defense-related host nitric oxide production", "definition": "The activation by a symbiont of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816639", "aliases": ["activation by symbiont of defense-related host respiratory burst", "induction by symbiont of defense-related host reactive oxidative species production", "activation by symbiont of defense-related host reactive oxygen species production", "induction by symbiont of defense-related host metabolic burst", "activation by symbiont of defense-related host reactive oxygen intermediate production", "activation by symbiont of defense-related host oxidative burst", "activation by symbiont of defense-related host ROS production", "activation by symbiont of defense-related host ROI production", "activation by symbiont of defense-related host reactive oxidative species production", "induction by symbiont of defense-related host oxidative burst", "induction by symbiont of defense-related host active oxygen species production", "induction by symbiont of defense-related host AOS production", "activation by symbiont of defense-related host metabolic burst"], "types": ["T043"], "canonical_name": "induction by symbiont of defense-related host reactive oxygen species production", "definition": "The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816643", "aliases": ["negative regulation by organism of entry into host cell via host phagocytosis", "down-regulation by symbiont of entry into host cell via phagocytosis", "downregulation by symbiont of entry into host cell via phagocytosis", "down regulation by symbiont of entry into host cell via phagocytosis"], "types": ["T040"], "canonical_name": "negative regulation by symbiont of entry into host cell via phagocytosis"}
{"concept_id": "C1816644", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of host jasmonic acid-mediated defense response"}
{"concept_id": "C1816645", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C1816646", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway"}
{"concept_id": "C1816647", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway"}
{"concept_id": "C1816651", "aliases": ["up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "induction by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "definition": "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816652", "aliases": [], "types": ["T040"], "canonical_name": "activation by organism of defense-related host salicylic acid-mediated signal transduction pathway"}
{"concept_id": "C1816653", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of defense-related host salicylic acid-mediated signal transduction pathway"}
{"concept_id": "C1816655", "aliases": [], "types": ["T040"], "canonical_name": "upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway"}
{"concept_id": "C1816656", "aliases": ["positive regulation by organism of defense-related host SA-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "positive regulation by organism of defense-related host SA-mediated signal transduction pathway"}
{"concept_id": "C1816657", "aliases": [], "types": ["T040"], "canonical_name": "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C1816658", "aliases": ["activation by organism of defense-related host SA-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "activation by organism of defense-related host SA-mediated signal transduction pathway"}
{"concept_id": "C1816659", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C1816660", "aliases": ["induction by organism of defense-related host SA-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "induction by organism of defense-related host SA-mediated signal transduction pathway"}
{"concept_id": "C1816661", "aliases": [], "types": ["T040"], "canonical_name": "upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C1816662", "aliases": ["upregulation by organism of defense-related host SA-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "upregulation by organism of defense-related host SA-mediated signal transduction pathway"}
{"concept_id": "C1816663", "aliases": ["upregulation by symbiont of host salicylic acid-mediated defense response", "positive regulation by organism of host SA-mediated defense response", "up-regulation by symbiont of host salicylic acid-mediated defense response", "up regulation by symbiont of host salicylic acid-mediated defense response"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host salicylic acid-mediated defense response", "definition": "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816664", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of host SA-mediated defense response"}
{"concept_id": "C1816665", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of host salicylic acid-mediated defense response"}
{"concept_id": "C1816666", "aliases": ["up regulation by symbiont of host jasmonic acid-mediated defense response", "positive regulation by organism of host JA-mediated defense response", "up-regulation by symbiont of host jasmonic acid-mediated defense response", "upregulation by symbiont of host jasmonic acid-mediated defense response"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host jasmonic acid-mediated defense response", "definition": "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816667", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of host JA-mediated defense response"}
{"concept_id": "C1816668", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of host jasmonic acid-mediated defense response"}
{"concept_id": "C1816669", "aliases": ["up regulation by symbiont of host ethylene-mediated defense response", "up-regulation by symbiont of host ethylene-mediated defense response", "positive regulation by symbiont of host ethylene-mediated defense response", "upregulation by symbiont of host ethylene-mediated defense response"], "types": ["T040"], "canonical_name": "induction by symbiont of host ethylene-mediated defense response", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816673", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway"}
{"concept_id": "C1816674", "aliases": ["negative regulation by organism of defense-related host MAPK-mediated signal transduction pathway", "suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway", "downregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway", "down regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway", "negative regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway", "negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway", "down-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "suppression by symbiont of defense-related host MAP kinase-mediated signal transduction pathway", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816675", "aliases": ["positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway", "positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway", "up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway", "up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway", "positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway", "upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "induction by symbiont of defense-related host MAP kinase-mediated signal transduction pathway", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816676", "aliases": [], "types": ["T040"], "canonical_name": "activation by organism of defense-related host MAP kinase-mediated signal transduction pathway"}
{"concept_id": "C1816677", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of defense-related host MAP kinase-mediated signal transduction pathway"}
{"concept_id": "C1816678", "aliases": [], "types": ["T040"], "canonical_name": "upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway"}
{"concept_id": "C1816679", "aliases": ["modulation of defense-related host MAPK-mediated signal transduction pathway by organism", "modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism", "modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "modulation by symbiont of host innate immune response MAPK kinase signaling", "definition": "Any process in which an organism modulates the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816680", "aliases": ["modulation of defense-related host SA-mediated signal transduction pathway by organism"], "types": ["T040"], "canonical_name": "modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway", "definition": "Any process in which an organism modulates the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816681", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C1816682", "aliases": ["down regulation by symbiont of host cell-mediated immune response", "down-regulation by symbiont of host cell-mediated immune response", "negative regulation by organism of host cell-based immune response", "downregulation by symbiont of host cell-mediated immune response"], "types": ["T040"], "canonical_name": "suppression by symbiont of host cell-mediated immune response", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816683", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host ethylene-mediated defense response", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816684", "aliases": ["down regulation by symbiont of host T-cell mediated immune response", "down-regulation by symbiont of host T-cell mediated immune response", "negative regulation by symbiont of host T-cell mediated immune response", "downregulation by symbiont of host T-cell mediated immune response"], "types": ["T040"], "canonical_name": "suppression by symbiont of host T-cell mediated immune response", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816685", "aliases": ["downregulation by symbiont of host B-cell mediated immune response", "down-regulation by symbiont of host B-cell mediated immune response", "down regulation by symbiont of host B-cell mediated immune response"], "types": ["T040"], "canonical_name": "suppression by symbiont of host B-cell mediated immune response", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816687", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of host JA-mediated defense response"}
{"concept_id": "C1816688", "aliases": ["modulation by organism of host SA-mediated defense response"], "types": ["T040"], "canonical_name": "modulation by symbiont of host salicylic acid-mediated defense response", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816690", "aliases": ["modulation by symbiont of nutrient release from host"], "types": ["T040"], "canonical_name": "modulation of nutrient release by host", "definition": "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816691", "aliases": ["upregulation by symbiont of nutrient release from host", "up regulation by symbiont of nutrient release from host", "promotion of nutrient release from host", "positive regulation by symbiont of nutrient release from host", "up-regulation by symbiont of nutrient release from host"], "types": ["T040"], "canonical_name": "positive regulation of nutrient release by host", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816692", "aliases": ["formation of specialized structure for nutrient acquisition from host", "formation by organism of specialized structure for nutrient acquisition from host", "formation by symbiont of specialized structure for nutrient acquisition from host"], "types": ["T043"], "canonical_name": "formation of specialized structure for nutrient acquisition", "definition": "The assembly of a symbiotic cellular or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816693", "aliases": ["formation by symbiont of haustorium for nutrient acquisition from host", "formation by organism of haustoria for nutrient acquisition from host", "formation by organism of haustorium for nutrient acquisition from host"], "types": ["T043"], "canonical_name": "formation of haustorium for nutrient acquisition", "definition": "The assembly of a haustorium, a projection from a symbiotic cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816696", "aliases": ["formation by symbiont of syncytium involving giant cell for nutrient acquisition from host", "formation by organism of syncytium involving giant cell for nutrient acquisition from host"], "types": ["T043"], "canonical_name": "formation of syncytium involving giant cell for nutrient acquisition", "definition": "The assembly of a syncytium, a multi-nucleate and physiologically active aggregation of fused root cells induced by a symbiotic nematode in a plant host. The syncytium exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C1816698", "aliases": [], "types": ["T043"], "canonical_name": "formation by host of specialized structure for nutrient acquisition from symbiont", "definition": "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816699", "aliases": [], "types": ["T040"], "canonical_name": "acquisition by symbiont of nutrients from host via siderophores"}
{"concept_id": "C1816702", "aliases": ["up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway", "upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway", "positive regulation of defense-related host CDPK pathway by organism", "up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816703", "aliases": ["activation by organism of induced systemic resistance in host", "induction by organism of ISR in host", "induction by symbiont of induced systemic resistance in host", "activation by organism of ISR in host"], "types": ["T040"], "canonical_name": "induction by symbiont of host induced systemic resistance", "definition": "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816704", "aliases": ["activation by organism of systemic acquired resistance in host", "activation by organism of SAR in host", "induction by symbiont of systemic acquired resistance in host", "induction by organism of SAR in host"], "types": ["T040"], "canonical_name": "induction by symbiont of host systemic acquired resistance", "definition": "Any process in which a symbiont activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816713", "aliases": [], "types": ["T040"], "canonical_name": "occlusion by symbiont of host vascular system", "definition": "The process in which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]"}
{"concept_id": "C1816714", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host structure", "definition": "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816715", "aliases": [], "types": ["T040"], "canonical_name": "occlusion by symbiont of host xylem", "definition": "The process in which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816731", "aliases": [], "types": ["T043"], "canonical_name": "positive energy taxis", "definition": "The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816732", "aliases": [], "types": ["T043"], "canonical_name": "negative energy taxis", "definition": "The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816733", "aliases": [], "types": ["T043"], "canonical_name": "negative aerotaxis", "definition": "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen. [GOC:dph, GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816734", "aliases": [], "types": ["T043"], "canonical_name": "positive aerotaxis", "definition": "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen. [GOC:dph, GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816753", "aliases": ["modulation by organism of host apoptotic programmed cell death"], "types": ["T040"], "canonical_name": "modulation by symbiont of host apoptotic process", "definition": "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816754", "aliases": ["upregulation by organism of host apoptotic programmed cell death", "induction by symbiont of host apoptosis", "up regulation by organism of host apoptotic programmed cell death", "activation by organism of host apoptotic programmed cell death", "up-regulation by organism of host apoptotic programmed cell death", "activation by organism of host apoptosis", "upregulation by symbiont of host apoptosis", "up regulation by symbiont of host apoptosis", "induction by organism of host apoptotic programmed cell death", "up-regulation by symbiont of host apoptosis", "positive regulation by organism of host apoptotic programmed cell death"], "types": ["T044"], "canonical_name": "positive regulation by symbiont of host apoptotic process", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:jl, GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816755", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host non-apoptotic programmed cell death"}
{"concept_id": "C1816756", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host non-apoptotic programmed cell death"}
{"concept_id": "C1816757", "aliases": ["regulation by organism of host B-cell mediated immune response"], "types": ["T040"], "canonical_name": "modulation by symbiont of host B-cell mediated immune response", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816758", "aliases": ["modulation by organism of host cell-based immune response"], "types": ["T040"], "canonical_name": "modulation by symbiont of host cell-mediated immune response", "definition": "Any process in which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816759", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host T-cell mediated immune response", "definition": "Any process in which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816761", "aliases": ["modulation by organism of host gene-for-gene resistance", "modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont", "modulation by organism of defense response in host by specific elicitors"], "types": ["T040"], "canonical_name": "modulation by symbiont of host resistance gene-dependent defense response", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816762", "aliases": ["modulation by symbiont of induced systemic resistance in host"], "types": ["T040"], "canonical_name": "modulation by symbiont of host induced systemic resistance", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816763", "aliases": ["modulation by symbiont of systemic acquired resistance in host"], "types": ["T040"], "canonical_name": "modulation by symbiont of host systemic acquired resistance", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816766", "aliases": ["modulation by organism of defense-related host Ca2+ flux"], "types": ["T040"], "canonical_name": "modulation by symbiont of defense-related host calcium ion flux", "definition": "Any process in which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816767", "aliases": ["evasion or tolerance by symbiont of host-produced nitric oxide", "evasion or tolerance of NO produced by host in response to organism", "evasion or tolerance by organism of host nitric oxide", "evasion or tolerance by organism of host-produced nitric oxide", "modulation by organism of defense-related host NO production", "modulation by symbiont of defense-related host nitric oxide production", "evasion or tolerance of nitric oxide produced by host in response to organism", "evasion or tolerance by organism of host-produced NO", "evasion or tolerance by organism of host NO"], "types": ["T040"], "canonical_name": "symbiont defense to host-produced nitric oxide", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the production of nitric oxide as part of the innate immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816768", "aliases": ["evasion or tolerance of defense-related host respiratory burst", "evasion or tolerance of host-produced active oxygen species", "evasion or tolerance of defense-related host metabolic burst", "modulation by symbiont of defense-related host reactive oxygen species production", "modulation by organism of defense-related host reactive oxidative species production", "modulation by organism of defense-related host metabolic burst", "modulation by organism of defense-related host ROS production", "evasion or tolerance of host-produced reactive oxygen intermediates", "modulation by organism of defense-related host AOS production", "evasion or tolerance by symbiont of host-produced reactive oxygen species", "evasion or tolerance by organism of reactive oxygen species produced during host defense response", "evasion or tolerance of host-produced ROS", "evasion or tolerance of host-produced ROIs", "evasion or tolerance of host-produced AOS", "modulation by organism of defense-related host respiratory burst", "modulation by organism of defense-related host oxidative burst", "evasion or tolerance of reactive oxygen species produced by host", "modulation by organism of defense-related host active oxygen species production", "modulation by organism of defense-related host reactive oxygen intermediate production", "evasion or tolerance by organism of host-produced reactive oxygen species", "evasion or tolerance of defense-related host oxidative burst", "modulation by organism of defense-related host ROI production"], "types": ["T040"], "canonical_name": "symbiont defense to host-produced reactive oxygen species", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816769", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host phytoalexin production"}
{"concept_id": "C1816770", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host innate immune response"}
{"concept_id": "C1816773", "aliases": ["modulation of host innate immune response", "modulation by symbiont of host innate immunity"], "types": ["T040"], "canonical_name": "modulation by symbiont of host innate immune response", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816774", "aliases": ["modulation by organism of defense-related host CDPK pathway"], "types": ["T040"], "canonical_name": "modulation by symbiont of defense-related host calcium-dependent protein kinase pathway", "definition": "Any process in which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816776", "aliases": ["negative regulation by symbiont of host innate immunity", "negative regulation by symbiont of host innate immune response", "down-regulation by symbiont of host innate immunity", "negative regulation of host innate immune response", "downregulation by symbiont of host innate immunity", "down regulation by symbiont of host innate immunity"], "types": ["T040"], "canonical_name": "suppression by symbiont of host innate immune response", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816779", "aliases": [], "types": ["T040"], "canonical_name": "response to defenses of other organism during symbiotic interaction"}
{"concept_id": "C1816789", "aliases": [], "types": ["T043"], "canonical_name": "modification by host of symbiont structure", "definition": "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816792", "aliases": [], "types": ["T040"], "canonical_name": "modification by host of symbiont cellular component", "definition": "The process in which an organism effects a change in the structure or function of a symbiont cellular component. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816805", "aliases": [], "types": ["T040"], "canonical_name": "response to host defenses", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816806", "aliases": [], "types": ["T040"], "canonical_name": "response to symbiont defenses", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816857", "aliases": [], "types": ["T043"], "canonical_name": "induction by organism of defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816858", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction"}
{"concept_id": "C1816859", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816860", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816864", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by organism of pathogen-associated molecular pattern-induced innate immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816867", "aliases": [], "types": ["T043"], "canonical_name": "suppression of defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816869", "aliases": [], "types": ["T043"], "canonical_name": "induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction"}
{"concept_id": "C1816870", "aliases": [], "types": ["T043"], "canonical_name": "induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction"}
{"concept_id": "C1816871", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction"}
{"concept_id": "C1816872", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816873", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C1816881", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C1816888", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816891", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816898", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C1816899", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C1816903", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C1816909", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816910", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816915", "aliases": [], "types": ["T043"], "canonical_name": "induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction"}
{"concept_id": "C1816922", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C1816931", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction"}
{"concept_id": "C1816933", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction"}
{"concept_id": "C1816935", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of innate immune response in other organism"}
{"concept_id": "C1816936", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of innate immune response in other organism involved in symbiotic interaction"}
{"concept_id": "C1816937", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C1816939", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of innate immune response in other organism"}
{"concept_id": "C1816944", "aliases": ["phytoalexin metabolism"], "types": ["T043"], "canonical_name": "phytoalexin metabolic process", "definition": "The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response. [Wikipedia:Phytoalexin]"}
{"concept_id": "C1816945", "aliases": ["phytoalexin biosynthesis"], "types": ["T043"], "canonical_name": "phytoalexin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response. [Wikipedia:Phytoalexin]"}
{"concept_id": "C1816946", "aliases": ["phytoalexin catabolism"], "types": ["T043"], "canonical_name": "phytoalexin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response. [GOC:ai]"}
{"concept_id": "C1816947", "aliases": ["camalexin metabolism"], "types": ["T044"], "canonical_name": "camalexin metabolic process", "definition": "The chemical reactions and pathways involving camalexin, an indole phytoalexin. [GOC:ai]"}
{"concept_id": "C1816948", "aliases": ["regulation of phytoalexin metabolism"], "types": ["T044"], "canonical_name": "regulation of phytoalexin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response. [GOC:ai]"}
{"concept_id": "C1816949", "aliases": ["regulation of phytoalexin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of phytoalexin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. [GOC:ai]"}
{"concept_id": "C1816950", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phytoalexin metabolism"}
{"concept_id": "C1816951", "aliases": ["downregulation of phytoalexin metabolism", "down-regulation of phytoalexin metabolism", "negative regulation of phytoalexin metabolism", "down regulation of phytoalexin metabolism"], "types": ["T044"], "canonical_name": "negative regulation of phytoalexin metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins. [GOC:ai]"}
{"concept_id": "C1816952", "aliases": ["upregulation of phytoalexin biosynthesis", "positive regulation of phytoalexin biosynthesis", "up regulation of phytoalexin biosynthesis", "up-regulation of phytoalexin biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of phytoalexin biosynthetic process", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816953", "aliases": ["down regulation of phytoalexin biosynthesis", "negative regulation of phytoalexin biosynthesis", "down-regulation of phytoalexin biosynthesis", "downregulation of phytoalexin biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of phytoalexin biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. [GOC:ai]"}
{"concept_id": "C1816954", "aliases": ["cell wall cellulose biosynthesis"], "types": ["T044"], "canonical_name": "plant-type cell wall cellulose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall. [GOC:ai]"}
{"concept_id": "C1816955", "aliases": [], "types": ["T044"], "canonical_name": "cellulose biosynthesis during cell wall biosynthesis"}
{"concept_id": "C1816956", "aliases": ["cell wall pectin biosynthesis", "pectin biosynthesis during cell wall organization and biogenesis"], "types": ["T044"], "canonical_name": "cell wall pectin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall. [GOC:ai]"}
{"concept_id": "C1816964", "aliases": [], "types": ["T040"], "canonical_name": "modification by host of symbiont cytoskeleton", "definition": "The process in which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816965", "aliases": ["metabolism of symbiont cell wall by organism"], "types": ["T040"], "canonical_name": "modification by host of symbiont cell wall", "definition": "The process in which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [ISBN:0198547684]"}
{"concept_id": "C1816966", "aliases": ["modification by host of symbiont cell membrane"], "types": ["T043"], "canonical_name": "modification by host of symbiont membrane", "definition": "The process in which an organism effects a change in the structure or function of a symbiont cellular membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816967", "aliases": ["degradation of symbiont cell wall by organism", "catabolism of symbiont cell wall by organism", "disassembly by host of symbiont cell wall"], "types": ["T040"], "canonical_name": "disruption by host of symbiont cell wall", "definition": "The chemical reactions and pathways performed by an organism resulting in the breakdown of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [ISBN:0198547684]"}
{"concept_id": "C1816972", "aliases": ["upregulation by symbiont of host phytoalexin production", "up regulation by symbiont of host phytoalexin production", "up-regulation by symbiont of host phytoalexin production"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host phytoalexin production", "definition": "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816974", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of defense-related host nitric oxide production"}
{"concept_id": "C1816975", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction"}
{"concept_id": "C1816991", "aliases": ["disassembly by host of symbiont cellular component", "catabolism of symbiont cellular component by organism", "degradation of symbiont cellular component by organism", "catabolism of symbiont structural constituent by organism"], "types": ["T040"], "canonical_name": "disruption by host of symbiont cellular component", "definition": "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [ISBN:0198547684]"}
{"concept_id": "C1816993", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of defense-related host reactive oxygen species production"}
{"concept_id": "C1816995", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of entry into other organism during symbiotic interaction"}
{"concept_id": "C1816996", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of entry into host", "definition": "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1816997", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by organism of entry into other organism during symbiotic interaction"}
{"concept_id": "C1817001", "aliases": [], "types": ["T040"], "canonical_name": "phytoalexin detoxification"}
{"concept_id": "C1817003", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of entry into host via phagocytosis"}
{"concept_id": "C1817005", "aliases": [], "types": ["T040"], "canonical_name": "evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction"}
{"concept_id": "C1817007", "aliases": [], "types": ["T043"], "canonical_name": "cell wall thickening", "definition": "A type of cell wall modification in which the cell wall is reinforced and made thicker. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817009", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of defense-related host calcium ion flux"}
{"concept_id": "C1817010", "aliases": ["activation by organism of host innate immune response", "upregulation by symbiont of host innate immunity", "induction by symbiont of host innate immunity", "activation by symbiont of host innate immunity", "activation by organism of host innate immunity", "induction of host innate immunity"], "types": ["T040"], "canonical_name": "induction by symbiont of host innate immune response", "definition": "The activation by a symbiont of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817011", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of host innate immune response"}
{"concept_id": "C1817012", "aliases": ["activation by symbiont of defense-related host calcium ion flux", "induction by organism of host Ca2+ flux", "activation by organism of host Ca2+ flux", "activation by organism of host calcium ion flux"], "types": ["T040"], "canonical_name": "induction by symbiont of defense-related host calcium ion flux", "definition": "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817016", "aliases": ["inhibition of symbiont enzyme activity", "down regulation by host of symbiont enzyme activity", "negative regulation by host of symbiont enzyme activity", "down-regulation by host of symbiont enzyme activity", "downregulation by host of symbiont enzyme activity"], "types": ["T043"], "canonical_name": "negative regulation by host of symbiont catalytic activity", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817038", "aliases": [], "types": ["T040"], "canonical_name": "modulation by host of symbiont molecular function"}
{"concept_id": "C1817039", "aliases": [], "types": ["T040"], "canonical_name": "modulation by host of symbiont RNA levels", "definition": "The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817043", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C1817044", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C1817048", "aliases": ["modulation by host of nutrient release from symbiont"], "types": ["T043"], "canonical_name": "modulation of nutrient release by symbiont", "definition": "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817052", "aliases": [], "types": ["T040"], "canonical_name": "modulation by host of symbiont transcription", "definition": "Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817053", "aliases": ["cell wall thickening during defense response"], "types": ["T040"], "canonical_name": "defense response by cell wall thickening", "definition": "A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817055", "aliases": ["inhibition of symbiont programmed cell death", "downregulation by host of symbiont programmed cell death", "down regulation by host of symbiont programmed cell death", "down-regulation by host of symbiont programmed cell death"], "types": ["T040"], "canonical_name": "negative regulation by host of symbiont programmed cell death", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817059", "aliases": [], "types": ["T043"], "canonical_name": "occlusion by host of symbiont vascular system", "definition": "The process in which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]"}
{"concept_id": "C1817061", "aliases": [], "types": ["T043"], "canonical_name": "occlusion by host of symbiont xylem", "definition": "The process in which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817068", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host defense response"}
{"concept_id": "C1817070", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction"}
{"concept_id": "C1817072", "aliases": ["upregulation by host of nutrient release from symbiont", "positive regulation by host of nutrient release from symbiont", "promotion of nutrient release from symbiont", "up-regulation by host of nutrient release from symbiont", "up regulation by host of nutrient release from symbiont"], "types": ["T043"], "canonical_name": "positive regulation of nutrient release by symbiont", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817078", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host resistance gene-dependent defense response"}
{"concept_id": "C1817081", "aliases": ["positive regulation by symbiont of host induced systemic resistance"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of induced systemic resistance in host"}
{"concept_id": "C1817083", "aliases": ["positive regulation by symbiont of host systemic acquired resistance"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of systemic acquired resistance in host"}
{"concept_id": "C1817086", "aliases": ["cell wall cellulose metabolism", "cellulose and pectin-containing cell wall cellulose metabolic process"], "types": ["T044"], "canonical_name": "plant-type cell wall cellulose metabolic process", "definition": "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1817087", "aliases": ["callose localization during defense response", "callose deposition during defense response"], "types": ["T040"], "canonical_name": "defense response by callose deposition", "definition": "Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817088", "aliases": ["callose localization in cell wall", "cell wall callose localization", "cell wall callose deposition"], "types": ["T043"], "canonical_name": "callose deposition in cell wall", "definition": "Any process in which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817089", "aliases": ["cell wall callose deposition during defense response", "callose deposition in cell wall during defense response", "cell wall callose localization during defense response", "callose localization in cell wall during defense response"], "types": ["T040"], "canonical_name": "defense response by callose deposition in cell wall", "definition": "Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817090", "aliases": ["callose localisation"], "types": ["T038"], "canonical_name": "callose localization", "definition": "Any process in which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. [GOC:mtg_pamgo_17jul06, PMID:18397379]"}
{"concept_id": "C1817091", "aliases": ["plant-type cell wall pectin metabolic process", "cell wall pectin metabolism", "pectin metabolism during cell wall biogenesis", "cellulose and pectin-containing cell wall pectin metabolic process"], "types": ["T044"], "canonical_name": "cell wall pectin metabolic process", "definition": "The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall. [GOC:ai]"}
{"concept_id": "C1817092", "aliases": [], "types": ["T044"], "canonical_name": "regulation of peptidase activity", "definition": "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. [GOC:ai]"}
{"concept_id": "C1817093", "aliases": ["peptidase regulator activity"], "types": ["T044"], "canonical_name": "peptidase regulator activity", "definition": "Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. [GOC:dph, GOC:tb]"}
{"concept_id": "C1817095", "aliases": [], "types": ["T044"], "canonical_name": "protease regulator activity"}
{"concept_id": "C1817100", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host immune response", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817102", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host immune response"}
{"concept_id": "C1817104", "aliases": ["upregulation by symbiont of host immune response", "activation by symbiont of host immune response"], "types": ["T040"], "canonical_name": "induction by symbiont of host immune response", "definition": "Any process in which a symbiont activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817106", "aliases": ["downregulation by symbiont of host immune response", "negative regulation by symbiont of host immune response", "down regulation by symbiont of host immune response", "down-regulation by symbiont of host immune response"], "types": ["T040"], "canonical_name": "suppression by symbiont of host immune response", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817108", "aliases": [], "types": ["T040"], "canonical_name": "response to defense-related host nitric oxide production"}
{"concept_id": "C1817109", "aliases": [], "types": ["T040"], "canonical_name": "response to host phytoalexin production"}
{"concept_id": "C1817110", "aliases": [], "types": ["T040"], "canonical_name": "response to defense-related host reactive oxygen species production"}
{"concept_id": "C1817111", "aliases": [], "types": ["T040"], "canonical_name": "response to host immune response", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C1817112", "aliases": ["muscle fiber development", "myofiber development", "myofibre development", "muscle fibre development"], "types": ["T043"], "canonical_name": "muscle cell development", "definition": "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. [CL:0000187, GOC:devbiol]"}
{"concept_id": "C1817113", "aliases": [], "types": ["T043"], "canonical_name": "striated muscle cell development", "definition": "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. [CL:0000737, GOC:devbiol]"}
{"concept_id": "C1817114", "aliases": ["cardiac myofibril morphogenesis", "cardiac myofibril development"], "types": ["T042"], "canonical_name": "cardiac myofibril assembly", "definition": "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. [GOC:devbiol]"}
{"concept_id": "C1817115", "aliases": ["atrial heart myofibril development", "atrial cardiac myofibril development"], "types": ["T042"], "canonical_name": "atrial cardiac myofibril assembly", "definition": "The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. [GOC:devbiol]"}
{"concept_id": "C1817116", "aliases": ["ventricular heart myofibril development", "ventricular cardiac myofibril development"], "types": ["T043"], "canonical_name": "ventricular cardiac myofibril assembly", "definition": "The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. [GOC:devbiol]"}
{"concept_id": "C1817117", "aliases": ["cardiocyte development"], "types": ["T043"], "canonical_name": "cardiac cell development", "definition": "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. [GOC:devbiol]"}
{"concept_id": "C1817118", "aliases": ["cardiomyocyte differentiation", "heart muscle cell differentiation"], "types": ["T043"], "canonical_name": "cardiac muscle cell differentiation", "definition": "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. [GOC:devbiol, GOC:mtg_heart]"}
{"concept_id": "C1817122", "aliases": ["atrial heart muscle cell differentiation", "atrial cardiomyocyte differentiation"], "types": ["T043"], "canonical_name": "atrial cardiac muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ. [GOC:devbiol, GOC:mtg_heart]"}
{"concept_id": "C1817123", "aliases": ["ventricular heart muscle cell differentiation", "ventricular cardiomyocyte differentiation"], "types": ["T043"], "canonical_name": "ventricular cardiac muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. [GOC:devbiol, GOC:mtg_heart]"}
{"concept_id": "C1817124", "aliases": ["heart muscle cell development", "cardiac muscle fiber development", "cardiac muscle fibre development", "cardiomyocyte cell development"], "types": ["T043"], "canonical_name": "cardiac muscle cell development", "definition": "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. [GOC:devbiol, GOC:mtg_heart]"}
{"concept_id": "C1817125", "aliases": ["atrial cardiomyocyte development", "atrial heart muscle development"], "types": ["T043"], "canonical_name": "atrial cardiac muscle cell development", "definition": "The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ. [GOC:devbiol]"}
{"concept_id": "C1817126", "aliases": ["ventricular cardiomyocyte development", "ventricular heart muscle cell development"], "types": ["T043"], "canonical_name": "ventricular cardiac muscle cell development", "definition": "The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. [GOC:devbiol, GOC:mtg_muscle]"}
{"concept_id": "C1817127", "aliases": ["subnotochordal rod development"], "types": ["T042"], "canonical_name": "hypochord development", "definition": "The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta. [GOC:devbiol, GOC:lb]"}
{"concept_id": "C1817129", "aliases": ["regulation of cardiac muscle fibre development", "regulation of heart muscle fiber development"], "types": ["T039"], "canonical_name": "regulation of cardiac muscle fiber development", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. [GOC:vk]"}
{"concept_id": "C1817130", "aliases": ["downregulation of cardiac muscle fiber development", "down regulation of cardiac muscle fiber development", "negative regulation of cardiac muscle fibre development", "down-regulation of cardiac muscle fiber development"], "types": ["T039"], "canonical_name": "negative regulation of cardiac muscle fiber development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. [GOC:vk]"}
{"concept_id": "C1817131", "aliases": ["upregulation of cardiac muscle fiber development", "positive regulation of cardiac muscle fibre development", "up-regulation of cardiac muscle fiber development", "positive regulation of heart muscle fiber development", "up regulation of cardiac muscle fiber development"], "types": ["T039"], "canonical_name": "positive regulation of cardiac muscle fiber development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. [GOC:vk]"}
{"concept_id": "C1817132", "aliases": [], "types": ["T042"], "canonical_name": "regulation of cardiac muscle tissue growth", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle growth. [GOC:vk]"}
{"concept_id": "C1817138", "aliases": ["minus-end directed actin-filament motor activity", "minus-end directed actin filament motor activity", "pointed-end directed actin-filament motor activity"], "types": ["T044"], "canonical_name": "minus-end directed microfilament motor activity", "definition": "A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers. [GOC:dph, PMID:10519557]"}
{"concept_id": "C1817139", "aliases": ["barbed-end directed actin-filament motor activity", "plus-end directed actin-filament motor activity", "plus-end directed actin filament motor activity"], "types": ["T044"], "canonical_name": "plus-end directed microfilament motor activity", "definition": "A motor activity that generates movement along a microfilament towards the plus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers. [GOC:dph, PMID:10519557]"}
{"concept_id": "C1817140", "aliases": ["copper export"], "types": ["T043"], "canonical_name": "copper ion export", "definition": "The directed movement of copper ions out of a cell or organelle. [GOC:dph]"}
{"concept_id": "C1817142", "aliases": [], "types": ["T040"], "canonical_name": "angular vestibuloocular reflex", "definition": "A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. [GOC:dph, PMID:11784757]"}
{"concept_id": "C1817143", "aliases": [], "types": ["T040"], "canonical_name": "linear vestibuloocular reflex", "definition": "A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. [GOC:dph, PMID:11784757]"}
{"concept_id": "C1817144", "aliases": [], "types": ["T043"], "canonical_name": "Sertoli cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. [GOC:dph]"}
{"concept_id": "C1817145", "aliases": [], "types": ["T043"], "canonical_name": "Sertoli cell development", "definition": "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. [GOC:dph]"}
{"concept_id": "C1817146", "aliases": [], "types": ["T043"], "canonical_name": "Sertoli cell fate commitment", "definition": "The process in which the cellular identity of Sertoli cells is acquired and determined. [GOC:dph]"}
{"concept_id": "C1817147", "aliases": [], "types": ["T043"], "canonical_name": "Sertoli cell proliferation", "definition": "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. [GOC:dph]"}
{"concept_id": "C1817148", "aliases": ["glycinergic synaptic transmission"], "types": ["T043"], "canonical_name": "synaptic transmission, glycinergic", "definition": "The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos]"}
{"concept_id": "C1817149", "aliases": [], "types": ["T043"], "canonical_name": "granulosa cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals. [GOC:dph]"}
{"concept_id": "C1817150", "aliases": [], "types": ["T043"], "canonical_name": "granulosa cell fate commitment", "definition": "The cell fate commitment of precursor cells that will become granulosa cells. [GOC:dph]"}
{"concept_id": "C1817151", "aliases": [], "types": ["T043"], "canonical_name": "granulosa cell development", "definition": "The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate. [GOC:dph]"}
{"concept_id": "C1817152", "aliases": [], "types": ["T042"], "canonical_name": "parathyroid gland development", "definition": "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone. [GOC:dph, ISBN:0721662544]"}
{"concept_id": "C1817153", "aliases": [], "types": ["T043"], "canonical_name": "astrocyte fate commitment", "definition": "The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte. [GOC:dph]"}
{"concept_id": "C1817154", "aliases": [], "types": ["T043"], "canonical_name": "radial glial cell differentiation", "definition": "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph]"}
{"concept_id": "C1817155", "aliases": [], "types": ["T043"], "canonical_name": "Bergmann glial cell differentiation", "definition": "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph, PMID:10375501]"}
{"concept_id": "C1817156", "aliases": ["palatum development"], "types": ["T042"], "canonical_name": "roof of mouth development", "definition": "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. [GOC:dph, ISBN:0721662544]"}
{"concept_id": "C1817157", "aliases": ["palatum durum development"], "types": ["T042"], "canonical_name": "hard palate development", "definition": "The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes. [GOC:dph, ISBN:0721662544]"}
{"concept_id": "C1817158", "aliases": ["velum palatum development", "palatum molle development"], "types": ["T042"], "canonical_name": "soft palate development", "definition": "The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate. [GOC:dph, ISBN:0721662544]"}
{"concept_id": "C1817159", "aliases": [], "types": ["T042"], "canonical_name": "rhythmic synaptic transmission", "definition": "Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit. [GOC:dph]"}
{"concept_id": "C1817160", "aliases": [], "types": ["T038"], "canonical_name": "regulation of synaptic activity", "definition": "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C1817161", "aliases": [], "types": ["T042"], "canonical_name": "convergent extension", "definition": "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. [GOC:dgf, GOC:dph, PMID:12062082]"}
{"concept_id": "C1817162", "aliases": [], "types": ["T042"], "canonical_name": "convergent extension involved in gastrulation", "definition": "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. [GOC:dph, PMID:12062082]"}
{"concept_id": "C1817163", "aliases": [], "types": ["T042"], "canonical_name": "convergent extension involved in axis elongation", "definition": "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism. [GOC:dph, PMID:12062082]"}
{"concept_id": "C1817164", "aliases": [], "types": ["T042"], "canonical_name": "convergent extension involved in organogenesis", "definition": "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ. [GOC:dph, PMID:12062082]"}
{"concept_id": "C1817165", "aliases": [], "types": ["T043"], "canonical_name": "dorsal convergence", "definition": "The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement. [GOC:dgf, GOC:dph, PMID:12062082]"}
{"concept_id": "C1817166", "aliases": [], "types": ["T043"], "canonical_name": "mediolateral intercalation", "definition": "The interdigitation of cells along the mediolateral axis during gastrulation. [GOC:dgf, GOC:dph, PMID:12062082]"}
{"concept_id": "C1817167", "aliases": [], "types": ["T042"], "canonical_name": "notochord regression", "definition": "The developmental process in which the stucture of the notochord is destroyed in an embryo. [GOC:dph]"}
{"concept_id": "C1817168", "aliases": [], "types": ["T042"], "canonical_name": "anatomical structure regression", "definition": "The developmental process in which an anatomical stucture is destroyed as a part of its normal progression. [GOC:dph]"}
{"concept_id": "C1817169", "aliases": [], "types": ["T043"], "canonical_name": "notochord cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate. [GOC:dph]"}
{"concept_id": "C1817170", "aliases": [], "types": ["T043"], "canonical_name": "notochord cell development", "definition": "The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:dph]"}
{"concept_id": "C1817171", "aliases": [], "types": ["T043"], "canonical_name": "notochord cell vacuolation", "definition": "The assembly and arrangement of a vacuole within a cell of the notochord. [GOC:cb, GOC:dph, PMID:10964477]"}
{"concept_id": "C1817172", "aliases": [], "types": ["T042"], "canonical_name": "specification of axis polarity", "definition": "The pattern specification process in which the polarity of a body or organ axis is established and maintained. [GOC:mah]"}
{"concept_id": "C1817173", "aliases": ["intracellular protein transport across a membrane", "intracellular membrane translocation of a protein", "intracellular protein membrane transport"], "types": ["T043"], "canonical_name": "intracellular protein transmembrane transport", "definition": "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. [GOC:isa_complete]"}
{"concept_id": "C1817174", "aliases": ["macromolecule complex assembly"], "types": ["T044"], "canonical_name": "macromolecular complex assembly"}
{"concept_id": "C1817175", "aliases": ["DNA-protein complex assembly"], "types": ["T044"], "canonical_name": "protein-DNA complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. [GOC:jl]"}
{"concept_id": "C1817176", "aliases": [], "types": ["T044"], "canonical_name": "protein-lipid complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. [GOC:jl]"}
{"concept_id": "C1817177", "aliases": [], "types": ["T044"], "canonical_name": "protein-carbohydrate complex assembly"}
{"concept_id": "C1817178", "aliases": ["regulation of biological attribute", "regulation of biological characteristic"], "types": ["T038"], "canonical_name": "regulation of biological quality", "definition": "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]"}
{"concept_id": "C1817179", "aliases": ["regulation of a molecular function"], "types": ["T044"], "canonical_name": "regulation of molecular function", "definition": "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. [GOC:isa_complete]"}
{"concept_id": "C1817180", "aliases": ["extracellular membrane-enclosed organelle"], "types": ["T026"], "canonical_name": "extracellular membrane-bounded organelle", "definition": "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. [GOC:isa_complete]"}
{"concept_id": "C1817181", "aliases": [], "types": ["T044"], "canonical_name": "adenosine nucleotide receptor"}
{"concept_id": "C1817182", "aliases": ["deubiquitinase activity", "ubiquitinyl hydrolase activity"], "types": ["T044"], "definition": "An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:mec, PMID:30783221]", "canonical_name": "ubiquitin hydrolase activity"}
{"concept_id": "C1817185", "aliases": [], "types": ["T044"], "canonical_name": "platelet ADP receptor activity"}
{"concept_id": "C1817186", "aliases": ["PLC activating metabotropic glutamate receptor activity", "phospholipase C activating metabotropic glutamate receptor activity", "PLC activating G-protein coupled glutamate receptor activity"], "types": ["T044"], "canonical_name": "PLC activating G protein-coupled glutamate receptor activity", "definition": "A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system. [PMID:9016303]"}
{"concept_id": "C1817189", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome b2"}
{"concept_id": "C1817190", "aliases": [], "types": ["T044"], "canonical_name": "prophenol oxidase activity"}
{"concept_id": "C1817191", "aliases": ["RNase H2 activity"], "types": ["T045"], "canonical_name": "ribonuclease H2 activity"}
{"concept_id": "C1817192", "aliases": ["RNase H3 activity"], "types": ["T045"], "canonical_name": "ribonuclease H3 activity"}
{"concept_id": "C1817196", "aliases": [], "types": ["T045"], "canonical_name": "pre-mRNA 3'-end processing endonuclease"}
{"concept_id": "C1817197", "aliases": [], "types": ["T044"], "canonical_name": "alpha-glucosidase II"}
{"concept_id": "C1817198", "aliases": [], "types": ["T042"], "canonical_name": "neural plate development", "definition": "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]"}
{"concept_id": "C1817199", "aliases": [], "types": ["T043"], "canonical_name": "late phagosome biosynthesis"}
{"concept_id": "C1817200", "aliases": [], "types": ["T043"], "canonical_name": "late phagosome formation"}
{"concept_id": "C1817201", "aliases": [], "types": ["T040"], "canonical_name": "tissue maintenance"}
{"concept_id": "C1817202", "aliases": ["cytolysis by organism of host cells"], "types": ["T043"], "canonical_name": "cytolysis by symbiont of host cells", "definition": "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:add]"}
{"concept_id": "C1817203", "aliases": ["regulation by symbiont of cytolysis of host cells"], "types": ["T040"], "canonical_name": "regulation of cytolysis by symbiont of host cells", "definition": "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C1817204", "aliases": ["downregulation by symbiont of cytolysis of host cells", "down regulation by symbiont of cytolysis of host cells", "negative regulation by symbiont of cytolysis of host cells", "down-regulation by symbiont of cytolysis of host cells"], "types": ["T040"], "canonical_name": "negative regulation of cytolysis by symbiont of host cells", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C1817205", "aliases": ["upregulation by symbiont of cytolysis of host cells", "positive regulation by symbiont of cytolysis of host cells", "up regulation by symbiont of cytolysis of host cells", "up-regulation by symbiont of cytolysis of host cells"], "types": ["T040"], "canonical_name": "positive regulation of cytolysis by symbiont of host cells", "definition": "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C1817206", "aliases": [], "types": ["T043"], "canonical_name": "killing by symbiont of host cells", "definition": "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:add]"}
{"concept_id": "C1817207", "aliases": ["distal pole complex location"], "types": ["T026"], "canonical_name": "distal pole complex"}
{"concept_id": "C1817208", "aliases": [], "types": ["T026"], "canonical_name": "retractile pole"}
{"concept_id": "C1817210", "aliases": [], "types": ["T040"], "canonical_name": "baroreceptor pressure buffer system"}
{"concept_id": "C1817211", "aliases": [], "types": ["T040"], "canonical_name": "CNS ischemic response"}
{"concept_id": "C1817213", "aliases": [], "types": ["T044"], "canonical_name": "non-selenium glutathione peroxidase activity"}
{"concept_id": "C1817216", "aliases": [], "types": ["T044"], "canonical_name": "MEK activity"}
{"concept_id": "C1817217", "aliases": [], "types": ["T044"], "canonical_name": "serine palmitoyltransferase"}
{"concept_id": "C1817218", "aliases": [], "types": ["T044"], "canonical_name": "serine-pyruvate aminotransferase, type 1"}
{"concept_id": "C1817219", "aliases": [], "types": ["T044"], "canonical_name": "serine-pyruvate aminotransferase, type 2A"}
{"concept_id": "C1817220", "aliases": [], "types": ["T044"], "canonical_name": "serine-pyruvate aminotransferase, type 2B"}
{"concept_id": "C1817221", "aliases": [], "types": ["T044"], "canonical_name": "NADPH:sulfite reductase flavoprotein"}
{"concept_id": "C1817222", "aliases": ["aminoacyl-tRNA synthetase activity"], "types": ["T044"], "canonical_name": "aminoacyl-tRNA ligase activity", "definition": "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. [ISBN:0198506732]"}
{"concept_id": "C1817226", "aliases": ["smoothened ligand"], "types": ["T044"], "canonical_name": "smo ligand"}
{"concept_id": "C1817227", "aliases": ["DR binding"], "types": ["T044"], "canonical_name": "death receptor binding", "definition": "Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). [GOC:ceb, GOC:rl, PMID:15654015]"}
{"concept_id": "C1817229", "aliases": [], "types": ["T044"], "canonical_name": "growth hormone receptor ligand"}
{"concept_id": "C1817231", "aliases": [], "types": ["T044"], "canonical_name": "neutral amino acid:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in). [TC:2.A.23.3.1]"}
{"concept_id": "C1817232", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen/proline transporter"}
{"concept_id": "C1817233", "aliases": [], "types": ["T044"], "canonical_name": "dicarboxylate carrier"}
{"concept_id": "C1817235", "aliases": [], "types": ["T044"], "canonical_name": "sodium/chloride-dependent GABA transporter activity"}
{"concept_id": "C1817236", "aliases": [], "types": ["T044"], "canonical_name": "general alpha-glucoside transporter activity"}
{"concept_id": "C1817237", "aliases": ["low-affinity glucose-sodium cotransporter activity"], "types": ["T044"], "canonical_name": "low-affinity glucose:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [TC:2.A.21.3.-]"}
{"concept_id": "C1817239", "aliases": [], "types": ["T044"], "canonical_name": "maltose permease"}
{"concept_id": "C1817240", "aliases": [], "types": ["T044"], "canonical_name": "sodium/chloride-dependent taurine transporter"}
{"concept_id": "C1817242", "aliases": [], "types": ["T044"], "canonical_name": "SNAP-25"}
{"concept_id": "C1817243", "aliases": [], "types": ["T044"], "canonical_name": "cholecalciferol binding"}
{"concept_id": "C1817244", "aliases": [], "types": ["T044"], "canonical_name": "ergocalciferol binding"}
{"concept_id": "C1817245", "aliases": [], "types": ["T044"], "canonical_name": "xanthopsin"}
{"concept_id": "C1817246", "aliases": ["laminin-111 complex", "laminin-111 complex location", "laminin-1 complex location"], "types": ["T026"], "canonical_name": "laminin-1 complex", "definition": "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1817247", "aliases": ["laminin-211 complex location", "laminin-211 complex", "laminin-2 complex location"], "types": ["T026"], "canonical_name": "laminin-2 complex", "definition": "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1817248", "aliases": ["laminin-5A complex location", "laminin-3A32 complex", "laminin-3A32 complex location", "laminin-5A complex", "laminin-5 complex location"], "types": ["T026"], "canonical_name": "laminin-5 complex", "definition": "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1817249", "aliases": ["laminin-6 complex location", "laminin-6A complex location", "laminin-311 complex location", "laminin-311 complex", "laminin-6A complex"], "types": ["T026"], "canonical_name": "laminin-6 complex", "definition": "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1817250", "aliases": ["laminin-7A", "laminin-7 complex location"], "types": ["T026"], "canonical_name": "laminin-7 complex", "definition": "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1817251", "aliases": [], "types": ["T026"], "canonical_name": "mitochondrial stroma"}
{"concept_id": "C1817254", "aliases": ["muscle myosin complex location"], "types": ["T026"], "canonical_name": "muscle myosin complex", "definition": "A filament of myosin found in a muscle cell of any type. [GOC:mah]"}
{"concept_id": "C1817255", "aliases": [], "types": ["T026"], "canonical_name": "non-spindle-associated astral microtubule"}
{"concept_id": "C1817256", "aliases": [], "types": ["T026"], "canonical_name": "dense plaque"}
{"concept_id": "C1817257", "aliases": ["nexin complex location"], "types": ["T026"], "canonical_name": "nexin complex"}
{"concept_id": "C1817259", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glucose biosynthetic process"}
{"concept_id": "C1817260", "aliases": [], "types": ["T044"], "canonical_name": "'de novo' purine biosynthetic process"}
{"concept_id": "C1817261", "aliases": ["pyrimidine metabolic process"], "types": ["T044"], "canonical_name": "pyrimidine metabolic process", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1817262", "aliases": ["DNA biosynthesis", "DNA biosynthetic process", "DNA anabolism", "DNA synthesis"], "types": ["T045"], "definition": "The biosynthetic process resulting in the formation of DNA. [GOC:mah]", "canonical_name": "DNA formation"}
{"concept_id": "C1817263", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial DNA synthesis"}
{"concept_id": "C1817264", "aliases": [], "types": ["T045"], "canonical_name": "mtDNA synthesis"}
{"concept_id": "C1817265", "aliases": ["nuclear pre-replicative complex assembly", "pre-replicative complex assembly", "pre-replicative complex formation"], "types": ["T044"], "definition": "The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation. [GOC:mtg_cell_cycle]", "canonical_name": "pre-replicative complex assembly involved in nuclear cell cycle DNA replication"}
{"concept_id": "C1817266", "aliases": [], "types": ["T045"], "canonical_name": "replication priming"}
{"concept_id": "C1817267", "aliases": [], "types": ["T045"], "canonical_name": "long patch mismatch repair system"}
{"concept_id": "C1817268", "aliases": [], "types": ["T045"], "canonical_name": "mismatch repair, MutL-like pathway"}
{"concept_id": "C1817269", "aliases": [], "types": ["T045"], "canonical_name": "MutS/MutL/MutH pathway"}
{"concept_id": "C1817270", "aliases": ["DNA transposition", "Class II transposition"], "types": ["T045"], "canonical_name": "transposition, DNA-mediated", "definition": "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate. [GOC:jp, ISBN:0198506732, ISBN:1555812090]"}
{"concept_id": "C1817271", "aliases": [], "types": ["T045"], "canonical_name": "P-element excision"}
{"concept_id": "C1817272", "aliases": [], "types": ["T045"], "canonical_name": "P-element transposition"}
{"concept_id": "C1817273", "aliases": [], "types": ["T045"], "canonical_name": "Tc1/mariner transposition"}
{"concept_id": "C1817274", "aliases": [], "types": ["T045"], "canonical_name": "Tc3 transposition"}
{"concept_id": "C1817275", "aliases": ["spliceosomal E complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal E complex biosynthesis"}
{"concept_id": "C1817277", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine metabolic process"}
{"concept_id": "C1817278", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine catabolic process"}
{"concept_id": "C1817280", "aliases": [], "types": ["T044"], "canonical_name": "indolamine metabolic process"}
{"concept_id": "C1817281", "aliases": [], "types": ["T044"], "canonical_name": "triterpene metabolic process"}
{"concept_id": "C1817282", "aliases": [], "types": ["T044"], "canonical_name": "aromatic hydrocarbon metabolic process"}
{"concept_id": "C1817284", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme and prosthetic group metabolic process", "definition": "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups. [GOC:ai]"}
{"concept_id": "C1817286", "aliases": ["coenzyme Q10 biosynthetic process"], "types": ["T044"], "canonical_name": "coenzyme Q10 biosynthesis"}
{"concept_id": "C1817287", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme Q6 biosynthetic process"}
{"concept_id": "C1817288", "aliases": ["coenzyme Q8 biosynthetic process"], "types": ["T044"], "canonical_name": "coenzyme Q8 biosynthesis"}
{"concept_id": "C1817289", "aliases": ["coenzyme Q9 biosynthetic process"], "types": ["T044"], "canonical_name": "coenzyme Q9 biosynthesis"}
{"concept_id": "C1817290", "aliases": [], "types": ["T044"], "canonical_name": "niacin metabolic process"}
{"concept_id": "C1817291", "aliases": [], "types": ["T044"], "canonical_name": "vitamin B3 metabolic process"}
{"concept_id": "C1817292", "aliases": [], "types": ["T043"], "canonical_name": "asparagine transport", "definition": "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817293", "aliases": [], "types": ["T043"], "canonical_name": "glutamine transport", "definition": "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817294", "aliases": [], "types": ["T043"], "canonical_name": "phagosome biosynthesis"}
{"concept_id": "C1817296", "aliases": [], "types": ["T043"], "canonical_name": "endoplasmic reticulum morphology"}
{"concept_id": "C1817297", "aliases": ["noradrenaline-adrenalin catabolic process in blood stream"], "types": ["T044"], "canonical_name": "norepinephrine-epinephrine catabolic process in blood stream", "definition": "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream. [GOC:hjd]"}
{"concept_id": "C1817299", "aliases": [], "types": ["T040"], "canonical_name": "atrial reflex"}
{"concept_id": "C1817300", "aliases": [], "types": ["T044"], "canonical_name": "regulation of L-glutamate transport"}
{"concept_id": "C1817301", "aliases": ["downregulation of L-glutamate transport", "down regulation of L-glutamate transport", "down-regulation of L-glutamate transport"], "types": ["T044"], "canonical_name": "negative regulation of L-glutamate transport"}
{"concept_id": "C1817302", "aliases": ["upregulation of L-glutamate transport", "up regulation of L-glutamate import", "up-regulation of L-glutamate import", "upregulation of L-glutamate import", "up-regulation of L-glutamate transport"], "types": ["T044"], "canonical_name": "up regulation of L-glutamate transport"}
{"concept_id": "C1817303", "aliases": [], "types": ["T044"], "canonical_name": "p53 binding", "definition": "Binding to one of the p53 family of proteins. [GOC:hjd]"}
{"concept_id": "C1817304", "aliases": [], "types": ["T042"], "canonical_name": "sprouting angiogenesis", "definition": "The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. [PMID:16391003, PMID:23031691]"}
{"concept_id": "C1817305", "aliases": [], "types": ["T042"], "canonical_name": "intussusceptive angiogenesis", "definition": "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars. [PMID:16391003]"}
{"concept_id": "C1817307", "aliases": [], "types": ["T043"], "canonical_name": "blood vessel endothelial cell proliferation during sprouting angiogenesis"}
{"concept_id": "C1817310", "aliases": [], "types": ["T044"], "canonical_name": "opsin binding", "definition": "Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception. [GOC:hjd]"}
{"concept_id": "C1817311", "aliases": [], "types": ["T044"], "canonical_name": "phenazine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. [GOC:dph]"}
{"concept_id": "C1817312", "aliases": ["acridizine biosynthetic process"], "types": ["T044"], "canonical_name": "acridizine biosynthesis"}
{"concept_id": "C1817313", "aliases": ["azophenylene biosynthetic process"], "types": ["T044"], "canonical_name": "azophenylene biosynthesis"}
{"concept_id": "C1817314", "aliases": ["dibenzo-p-diazine biosynthetic process"], "types": ["T044"], "canonical_name": "dibenzo-p-diazine biosynthesis"}
{"concept_id": "C1817315", "aliases": ["dibenzopyrazine biosynthetic process"], "types": ["T044"], "canonical_name": "dibenzopyrazine biosynthesis"}
{"concept_id": "C1817316", "aliases": ["pyoverdine metabolism"], "types": ["T044"], "canonical_name": "pyoverdine metabolic process", "definition": "The chemical reactions and pathways involving the siderochrome pyoverdine. [PMID:15317763]"}
{"concept_id": "C1817317", "aliases": [], "types": ["T044"], "canonical_name": "pyoverdine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine. [PMID:15317763]"}
{"concept_id": "C1817318", "aliases": [], "types": ["T044"], "canonical_name": "pyoverdine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine. [PMID:15317763]"}
{"concept_id": "C1817319", "aliases": [], "types": ["T043"], "canonical_name": "osteoblast fate commitment", "definition": "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone. [GOC:dph]"}
{"concept_id": "C1817320", "aliases": ["upregulation of neuroblast proliferation", "up regulation of neuroblast proliferation", "up-regulation of neuroblast proliferation"], "types": ["T043"], "canonical_name": "positive regulation of neuroblast proliferation", "definition": "Any process that activates or increases the rate of neuroblast proliferation. [GOC:dph]"}
{"concept_id": "C1817321", "aliases": ["up regulation of mesenchymal cell proliferation", "upregulation of mesenchymal cell proliferation", "up-regulation of mesenchymal cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal cell proliferation", "definition": "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. [GOC:dph]"}
{"concept_id": "C1817322", "aliases": [], "types": ["T044"], "canonical_name": "nucleobase binding", "definition": "Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases. [GOC:hjd]"}
{"concept_id": "C1817323", "aliases": ["6-aminopurine binding"], "types": ["T044"], "canonical_name": "adenine binding", "definition": "Binding to adenine, a purine base. [GOC:hjd]"}
{"concept_id": "C1817324", "aliases": [], "types": ["T044"], "canonical_name": "cytosine binding", "definition": "Binding to cytosine. [GOC:hjd, GOC:vw]"}
{"concept_id": "C1817325", "aliases": [], "types": ["T044"], "canonical_name": "guanine binding", "definition": "Binding to guanine. [GOC:hjd]"}
{"concept_id": "C1817326", "aliases": [], "types": ["T044"], "canonical_name": "uracil binding", "definition": "Binding to uracil. [GOC:hjd]"}
{"concept_id": "C1817327", "aliases": [], "types": ["T044"], "canonical_name": "thymine binding", "definition": "Binding to thymine. [GOC:hjd]"}
{"concept_id": "C1817328", "aliases": [], "types": ["T044"], "canonical_name": "purine binding"}
{"concept_id": "C1817329", "aliases": ["pyrimidine binding"], "types": ["T044"], "canonical_name": "1,3-diazine binding"}
{"concept_id": "C1817330", "aliases": [], "types": ["T043"], "canonical_name": "chondrocyte differentiation", "definition": "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. [GOC:dph]"}
{"concept_id": "C1817331", "aliases": [], "types": ["T043"], "canonical_name": "chondrocyte development", "definition": "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. [GOC:dph]"}
{"concept_id": "C1817332", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell development", "definition": "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. [GOC:dph]"}
{"concept_id": "C1817333", "aliases": [], "types": ["T043"], "canonical_name": "columnar/cuboidal epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. [GOC:dph]"}
{"concept_id": "C1817334", "aliases": [], "types": ["T043"], "canonical_name": "columnar/cuboidal epithelial cell development", "definition": "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. [GOC:dph]"}
{"concept_id": "C1817335", "aliases": [], "types": ["T043"], "canonical_name": "glandular epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. [GOC:dph]"}
{"concept_id": "C1817336", "aliases": [], "types": ["T043"], "canonical_name": "glandular epithelial cell development", "definition": "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. [GOC:dph]"}
{"concept_id": "C1817337", "aliases": [], "types": ["T043"], "canonical_name": "columnar/cuboidal epithelial cell maturation", "definition": "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. [GOC:dph]"}
{"concept_id": "C1817338", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell maturation", "definition": "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. [GOC:dph]"}
{"concept_id": "C1817339", "aliases": [], "types": ["T043"], "canonical_name": "glandular epithelial cell maturation", "definition": "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. [GOC:dph]"}
{"concept_id": "C1817340", "aliases": ["optic cup morphogenesis involved in camera-style eye development"], "types": ["T042"], "canonical_name": "optic cup morphogenesis involved in camera-type eye development", "definition": "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]"}
{"concept_id": "C1817342", "aliases": [], "types": ["T042"], "canonical_name": "extraocular skeletal muscle development", "definition": "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus. [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982]"}
{"concept_id": "C1817344", "aliases": [], "types": ["T043"], "canonical_name": "osteoblast development", "definition": "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. [GOC:dph]"}
{"concept_id": "C1817345", "aliases": [], "types": ["T044"], "canonical_name": "acrosome matrix dispersal", "definition": "The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane. [GOC:dph, PMID:3886029]"}
{"concept_id": "C1817346", "aliases": ["membrane fusion involved in the acrosomal reaction"], "types": ["T044"], "canonical_name": "membrane fusion involved in acrosome reaction", "definition": "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane. [GOC:dph, PMID:3886029]"}
{"concept_id": "C1817347", "aliases": [], "types": ["T026"], "canonical_name": "inner acrosomal membrane", "definition": "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane. [GOC:dph, PMID:3899643, PMID:8936405]"}
{"concept_id": "C1817348", "aliases": [], "types": ["T026"], "canonical_name": "acrosomal membrane", "definition": "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. [GOC:dph]"}
{"concept_id": "C1817349", "aliases": [], "types": ["T026"], "canonical_name": "outer acrosomal membrane", "definition": "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction. [GOC:dph, PMID:8936405]"}
{"concept_id": "C1817350", "aliases": ["OXPHOS"], "types": ["T044"], "canonical_name": "regulation of oxidative phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. [GOC:dph]"}
{"concept_id": "C1817351", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxybenzoate decaprenyltransferase activity", "definition": "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate. [MetaCyc:RXN-9230]"}
{"concept_id": "C1817352", "aliases": [], "types": ["T044"], "canonical_name": "protein depalmitoylation", "definition": "The removal of palymitoyl groups from a lipoprotein. [GOC:hjd]"}
{"concept_id": "C1817353", "aliases": ["negative regulation of neural plate formation"], "types": ["T038"], "canonical_name": "repression of premature neural plate formation"}
{"concept_id": "C1817354", "aliases": [], "types": ["T042"], "canonical_name": "diaphragm contraction", "definition": "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange. [GOC:dph, GOC:mtg_muscle, PMID:12458206]"}
{"concept_id": "C1817355", "aliases": ["neurological control of breathing", "regulation of respiratory gaseous exchange by neurological system process"], "types": ["T040"], "canonical_name": "regulation of respiratory gaseous exchange by nervous system process", "definition": "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. [GOC:dph, GOC:tb, PMID:12458206]"}
{"concept_id": "C1817356", "aliases": ["lens development in camera-style eye", "lens development"], "types": ["T042"], "canonical_name": "lens development in camera-type eye", "definition": "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. [GOC:dph, ISBN:0582064333]"}
{"concept_id": "C1817357", "aliases": ["lens morphogenesis", "lens morphogenesis in camera-style eye"], "types": ["T040"], "canonical_name": "lens morphogenesis in camera-type eye", "definition": "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. [GOC:dph, GOC:mtg_sensu]"}
{"concept_id": "C1817358", "aliases": [], "types": ["T043"], "canonical_name": "regulation of receptor internalization", "definition": "Any process that modulates the frequency, rate or extent of receptor internalization. [GOC:hjd]"}
{"concept_id": "C1817359", "aliases": ["down-regulation of receptor internalization", "downregulation of receptor internalization", "down regulation of receptor internalization"], "types": ["T043"], "canonical_name": "negative regulation of receptor internalization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization. [GOC:hjd]"}
{"concept_id": "C1817360", "aliases": ["up-regulation of receptor internalization", "up regulation of receptor internalization", "upregulation of receptor internalization"], "types": ["T043"], "canonical_name": "positive regulation of receptor internalization", "definition": "Any process that activates or increases the frequency, rate or extent of receptor internalization. [GOC:hjd]"}
{"concept_id": "C1817361", "aliases": [], "types": ["T043"], "canonical_name": "auditory receptor cell morphogenesis", "definition": "Any process that alters the size or shape of an auditory receptor cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C1817362", "aliases": [], "types": ["T043"], "canonical_name": "hair cell morphogenesis"}
{"concept_id": "C1817363", "aliases": [], "types": ["T044"], "canonical_name": "polyprenyltransferase activity", "definition": "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). [GOC:hjd]"}
{"concept_id": "C1817364", "aliases": ["caveolar macromolecular signalling complex", "caveolar macromolecular signaling complex location", "caveolar macromolecular signalling complex location"], "types": ["T026"], "canonical_name": "caveolar macromolecular signaling complex", "definition": "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3). [PMID:16648270]"}
{"concept_id": "C1817365", "aliases": [], "types": ["T026"], "canonical_name": "polkadots", "definition": "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals. [PMID:14724296, PMID:16495340]"}
{"concept_id": "C1817366", "aliases": [], "types": ["T045"], "canonical_name": "tRNA wobble base modification", "definition": "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C1817367", "aliases": [], "types": ["T045"], "canonical_name": "tRNA wobble uridine modification", "definition": "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C1817368", "aliases": [], "types": ["T045"], "canonical_name": "tRNA wobble guanine modification", "definition": "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C1817369", "aliases": [], "types": ["T045"], "canonical_name": "tRNA wobble adenosine to inosine editing", "definition": "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C1817370", "aliases": [], "types": ["T045"], "canonical_name": "tRNA wobble cytosine modification", "definition": "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C1817371", "aliases": [], "types": ["T038"], "canonical_name": "somatic diversification of immune receptors", "definition": "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]"}
{"concept_id": "C1817372", "aliases": [], "types": ["T038"], "canonical_name": "somatic diversification of DSCAM-based immune receptors", "definition": "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects. [GOC:add, PMID:16261174]"}
{"concept_id": "C1817373", "aliases": [], "types": ["T038"], "canonical_name": "somatic diversification of variable lymphocyte receptors of jawless fish", "definition": "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish. [GOC:add, PMID:16373579]"}
{"concept_id": "C1817374", "aliases": [], "types": ["T044"], "canonical_name": "proteolysis by cytosolic proteases associated with antigen processing and presentation", "definition": "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation. [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]"}
{"concept_id": "C1817375", "aliases": ["somatic recombination of immunoglobulin genes during immune response"], "types": ["T045"], "canonical_name": "somatic recombination of antibody genes during immune response"}
{"concept_id": "C1817376", "aliases": ["somatic hypermutation of immunoglobulin genes during immune response"], "types": ["T045"], "canonical_name": "somatic hypermutation of antibody genes during immune response"}
{"concept_id": "C1817377", "aliases": ["gene conversion of antibody genes"], "types": ["T045"], "canonical_name": "gene conversion of immunoglobulin genes", "definition": "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion. [GOC:add, PMID:14991701]"}
{"concept_id": "C1817378", "aliases": ["gene conversion of immunoglobulin genes during immune response"], "types": ["T045"], "canonical_name": "gene conversion of antibody genes during immune response"}
{"concept_id": "C1817379", "aliases": ["somatic diversification of immunoglobulins during immune response"], "types": ["T043"], "canonical_name": "somatic diversification of antibodies during immune response"}
{"concept_id": "C1817380", "aliases": ["behavioural defense response"], "types": ["T040"], "canonical_name": "behavioral defense response", "definition": "A behavioral response seeking to protect an organism from an a perceived external threat to that organism. [GO_REF:0000022, GOC:add]"}
{"concept_id": "C1817381", "aliases": ["behavioural response to wounding"], "types": ["T055"], "canonical_name": "behavioral response to wounding", "definition": "A behavioral response resulting from wounding. [GO_REF:0000022, GOC:add]"}
{"concept_id": "C1817382", "aliases": ["behavioural defense response to insect"], "types": ["T040"], "canonical_name": "behavioral defense response to insect", "definition": "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism. [GOC:add]"}
{"concept_id": "C1817383", "aliases": ["behavioural defense response to nematode"], "types": ["T040"], "canonical_name": "behavioral defense response to nematode", "definition": "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism. [GOC:add, PMID:14506883]"}
{"concept_id": "C1817384", "aliases": ["physiological defense response to insect"], "types": ["T040"], "canonical_name": "defense response to insect", "definition": "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism. [GOC:add]"}
{"concept_id": "C1817385", "aliases": ["physiological defense response to nematode"], "types": ["T040"], "canonical_name": "defense response to nematode", "definition": "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. [GOC:add, PMID:11516579, PMID:14506883]"}
{"concept_id": "C1817386", "aliases": [], "types": ["T040"], "canonical_name": "activation of innate immune response", "definition": "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]"}
{"concept_id": "C1817388", "aliases": ["innate immune response activating cell surface receptor signalling pathway", "activation of innate immune response by cell surface receptor signaling pathway"], "types": ["T044"], "canonical_name": "innate immune response activating cell surface receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a cell surface receptor that leads to the activation of an innate immune response. [GOC:add, ISBN:0781735149, PMID:15199967]"}
{"concept_id": "C1817389", "aliases": ["PRR signaling pathway", "pathogen receptor signaling pathway", "pathogen receptor signalling pathway", "PAMP receptor signaling pathway"], "types": ["T044"], "canonical_name": "pattern recognition receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]"}
{"concept_id": "C1817390", "aliases": ["stimulatory killer cell immunoglobulin-like receptor signalling pathway", "stimulatory KIR signaling pathway"], "types": ["T044"], "canonical_name": "stimulatory killer cell immunoglobulin-like receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a killer cell immunoglobulin-like receptor capable of cellular activation. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817391", "aliases": ["stimulatory C-type lectin receptor signalling pathway"], "types": ["T044"], "canonical_name": "stimulatory C-type lectin receptor signaling pathway", "definition": "The series of molecular signals initiated by the binding of C-type lectin to its receptor on the surface of a target cell, and resulting in cellular activation. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817392", "aliases": [], "types": ["T044"], "canonical_name": "stimulatory Ly49 family receptor signaling pathway"}
{"concept_id": "C1817393", "aliases": ["toll-like receptor signaling pathway", "TLR signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by a ligand binding to a toll-like receptor on the surface of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]", "canonical_name": "toll-like receptor signalling pathway"}
{"concept_id": "C1817394", "aliases": ["upregulation of antimicrobial peptide production", "antimicrobial peptide induction", "up regulation of antimicrobial peptide production", "up-regulation of antimicrobial peptide production"], "types": ["T039"], "canonical_name": "positive regulation of antimicrobial peptide production", "definition": "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production. [GOC:add, PMID:11807545]"}
{"concept_id": "C1817396", "aliases": [], "types": ["T042"], "canonical_name": "innate immune response in mucosa", "definition": "Any process of the innate immune response that takes place in the mucosal tissues. [GOC:add, PMID:10719665, PMID:15971105]"}
{"concept_id": "C1817397", "aliases": ["NK cell mediated immunity"], "types": ["T046"], "canonical_name": "natural killer cell mediated immunity", "definition": "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817398", "aliases": [], "types": ["T040"], "canonical_name": "defense response to oomycetes", "definition": "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism. [GOC:add, PMID:16497589]"}
{"concept_id": "C1817399", "aliases": ["up regulation of antiviral response by host", "up-regulation of antiviral response by host", "upregulation of antiviral response by host", "positive regulation of antiviral response by host"], "types": ["T040"], "canonical_name": "positive regulation of defense response to virus by host", "definition": "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication. [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]"}
{"concept_id": "C1817400", "aliases": [], "types": ["T043"], "canonical_name": "detection of oomycetes", "definition": "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal. [GOC:add, PMID:15922649]"}
{"concept_id": "C1817401", "aliases": ["leukocyte chemotaxis during inflammatory response", "leucocyte chemotaxis during inflammatory response"], "types": ["T043"], "canonical_name": "immune cell chemotaxis during inflammatory response"}
{"concept_id": "C1817402", "aliases": ["leucocyte chemotaxis during immune response", "immune cell chemotaxis during immune response"], "types": ["T043"], "canonical_name": "leukocyte chemotaxis involved in immune response", "definition": "The movement of an immune cell in response to an external stimulus a part of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817403", "aliases": ["detection of ER overloading"], "types": ["T044"], "canonical_name": "detection of endoplasmic reticulum overloading", "definition": "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal. [GOC:add, PMID:10390516]"}
{"concept_id": "C1817404", "aliases": [], "types": ["T044"], "canonical_name": "detection of unfolded protein", "definition": "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal. [GOC:add, PMID:15226511, PMID:7765470]"}
{"concept_id": "C1817405", "aliases": [], "types": ["T039"], "canonical_name": "detection of misfolded protein", "definition": "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal. [GOC:add, PMID:15226511]"}
{"concept_id": "C1817406", "aliases": ["response to bacterium associated molecule", "response to bacteria associated molecule", "response to bacterial associated molecule"], "types": ["T040"], "canonical_name": "response to molecule of bacterial origin", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. [GOC:rl, GOC:sm]"}
{"concept_id": "C1817407", "aliases": ["response to fungus associated molecule"], "types": ["T040"], "canonical_name": "response to molecule of fungal origin", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide. [GOC:rl, GOC:sm]"}
{"concept_id": "C1817408", "aliases": [], "types": ["T040"], "canonical_name": "response to oomycetes", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes. [GOC:add, PMID:16497589]"}
{"concept_id": "C1817409", "aliases": ["response to oomycetes associated molecule"], "types": ["T040"], "canonical_name": "response to molecule of oomycetes origin", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin. [GOC:rl, GOC:sm]"}
{"concept_id": "C1817410", "aliases": [], "types": ["T040"], "canonical_name": "response to parasitic plant", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant. [GOC:add, PMID:16547862]"}
{"concept_id": "C1817411", "aliases": [], "types": ["T040"], "canonical_name": "defense response to parasitic plant", "definition": "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism. [GOC:add]"}
{"concept_id": "C1817412", "aliases": [], "types": ["T040"], "canonical_name": "detection of parasitic plant", "definition": "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal. [GOC:add, PMID:16547862]"}
{"concept_id": "C1817413", "aliases": ["hemopoietic progenitor cell differentiation", "haematopoietic progenitor cell differentiation", "haemopoietic progenitor cell differentiation"], "types": ["T043"], "canonical_name": "hematopoietic progenitor cell differentiation", "definition": "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]"}
{"concept_id": "C1817414", "aliases": [], "types": ["T040"], "canonical_name": "healing during inflammatory response"}
{"concept_id": "C1817415", "aliases": [], "types": ["T043"], "canonical_name": "clearance of damaged tissue during inflammatory response"}
{"concept_id": "C1817416", "aliases": [], "types": ["T042"], "canonical_name": "connective tissue replacement during inflammatory response"}
{"concept_id": "C1817417", "aliases": [], "types": ["T038"], "canonical_name": "fibrosis during inflammatory response"}
{"concept_id": "C1817418", "aliases": [], "types": ["T038"], "canonical_name": "lymphocyte anergy", "definition": "Any process contributing to lymphocyte anergy, a state of functional inactivation. [GOC:add]"}
{"concept_id": "C1817419", "aliases": ["immune response in organ or tissue"], "types": ["T040"], "canonical_name": "organ or tissue specific immune response", "definition": "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. [GO_REF:0000022, GOC:jal]"}
{"concept_id": "C1817420", "aliases": [], "types": ["T038"], "canonical_name": "immune effector process", "definition": "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817421", "aliases": [], "types": ["T040"], "canonical_name": "activation of immune response", "definition": "Any process that initiates an immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817422", "aliases": [], "types": ["T046"], "canonical_name": "kinin cascade", "definition": "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145]"}
{"concept_id": "C1817423", "aliases": ["glandular kallikrein-kinin cascade"], "types": ["T046"], "canonical_name": "tissue kallikrein-kinin cascade", "definition": "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. [GOC:add, PMID:11842287, PMID:14501145]"}
{"concept_id": "C1817424", "aliases": [], "types": ["T038"], "canonical_name": "regulation of kinin cascade", "definition": "Any process that modulates the frequency, rate, or extent of the kinin cascade. [GOC:jal]"}
{"concept_id": "C1817425", "aliases": ["down-regulation of kinin cascade", "down regulation of kinin cascade", "downregulation of kinin cascade"], "types": ["T039"], "canonical_name": "negative regulation of kinin cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade. [GOC:jal]"}
{"concept_id": "C1817426", "aliases": ["up-regulation of kinin cascade", "up regulation of kinin cascade", "upregulation of kinin cascade"], "types": ["T039"], "canonical_name": "positive regulation of kinin cascade", "definition": "Any process that activates or increases the frequency, rate, or extent of the kinin cascade. [GOC:jal]"}
{"concept_id": "C1817427", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell activation within high endothelial venule during immune response"}
{"concept_id": "C1817428", "aliases": [], "types": ["T043"], "canonical_name": "lymphocyte homeostasis", "definition": "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]"}
{"concept_id": "C1817429", "aliases": [], "types": ["T043"], "canonical_name": "mucosal lymphocyte homeostasis", "definition": "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus. [GOC:add, PMID:15609020]"}
{"concept_id": "C1817430", "aliases": [], "types": ["T043"], "canonical_name": "myeloid cell homeostasis", "definition": "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [CL:0000763, GOC:add]"}
{"concept_id": "C1817431", "aliases": [], "types": ["T043"], "canonical_name": "cell activation during immune response"}
{"concept_id": "C1817432", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell activation during immune response"}
{"concept_id": "C1817433", "aliases": [], "types": ["T043"], "canonical_name": "astrocyte activation during immune response"}
{"concept_id": "C1817434", "aliases": [], "types": ["T043"], "canonical_name": "follicular dendritic cell activation", "definition": "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:add, PMID:15606789]"}
{"concept_id": "C1817435", "aliases": [], "types": ["T043"], "canonical_name": "follicular dendritic cell activation during immune response"}
{"concept_id": "C1817436", "aliases": [], "types": ["T043"], "canonical_name": "follicular dendritic cell differentiation", "definition": "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817437", "aliases": ["leukocyte activation during inflammatory response"], "types": ["T043"], "canonical_name": "immune cell activation during inflammatory response"}
{"concept_id": "C1817438", "aliases": [], "types": ["T043"], "canonical_name": "plasmacytoid dendritic cell activation", "definition": "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:add, PMID:15990333, PMID:16174109]"}
{"concept_id": "C1817439", "aliases": [], "types": ["T043"], "canonical_name": "plasmacytoid dendritic cell activation during immune response"}
{"concept_id": "C1817440", "aliases": [], "types": ["T043"], "canonical_name": "plasmacytoid dendritic cell differentiation during immune response"}
{"concept_id": "C1817441", "aliases": [], "types": ["T043"], "canonical_name": "plasmacytoid dendritic cell differentiation", "definition": "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell. [GOC:add, PMID:15990333, PMID:16174108]"}
{"concept_id": "C1817442", "aliases": ["myeloid leucocyte activation"], "types": ["T043"], "canonical_name": "myeloid leukocyte activation", "definition": "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817443", "aliases": [], "types": ["T043"], "canonical_name": "myeloid cell activation during immune response"}
{"concept_id": "C1817444", "aliases": [], "types": ["T043"], "canonical_name": "basophil activation during immune response"}
{"concept_id": "C1817445", "aliases": [], "types": ["T043"], "canonical_name": "myeloid dendritic cell activation during immune response"}
{"concept_id": "C1817446", "aliases": [], "types": ["T043"], "canonical_name": "eosinophil activation during immune response"}
{"concept_id": "C1817447", "aliases": [], "types": ["T043"], "canonical_name": "mast cell activation during immune response"}
{"concept_id": "C1817448", "aliases": [], "types": ["T043"], "canonical_name": "monocyte activation during immune response"}
{"concept_id": "C1817449", "aliases": [], "types": ["T043"], "canonical_name": "macrophage activation during immune response"}
{"concept_id": "C1817450", "aliases": [], "types": ["T043"], "canonical_name": "microglial cell activation during immune response"}
{"concept_id": "C1817451", "aliases": [], "types": ["T043"], "canonical_name": "neutrophil activation during immune response"}
{"concept_id": "C1817452", "aliases": [], "types": ["T043"], "canonical_name": "myeloid dendritic cell differentiation during immune response"}
{"concept_id": "C1817453", "aliases": [], "types": ["T043"], "canonical_name": "lymphocyte activation during immune response"}
{"concept_id": "C1817454", "aliases": ["T lymphocyte activation during immune response", "T-cell activation during immune response", "T-lymphocyte activation during immune response"], "types": ["T043"], "canonical_name": "T cell activation during immune response"}
{"concept_id": "C1817455", "aliases": ["alpha-beta T-cell activation during immune response", "alpha-beta T-lymphocyte activation during immune response", "alpha-beta T lymphocyte activation during immune response"], "types": ["T043"], "canonical_name": "alpha-beta T cell activation during immune response"}
{"concept_id": "C1817456", "aliases": ["natural killer T-cell activation during immune response", "NK T-lymphocyte activation during immune response", "NK T cell activation during immune response", "NK T lymphocyte activation during immune response", "natural killer T-lymphocyte activation during immune response", "NK T-cell activation during immune response"], "types": ["T043"], "canonical_name": "natural killer T lymphocyte activation during immune response"}
{"concept_id": "C1817457", "aliases": ["NK T-lymphocyte proliferation during immune response", "natural killer T-cell proliferation during immune response", "NK T lymphocyte proliferation during immune response", "NK T cell proliferation during immune response", "NK T-cell proliferation during immune response", "natural killer T-lymphocyte proliferation during immune response"], "types": ["T043"], "canonical_name": "natural killer T lymphocyte proliferation during immune response"}
{"concept_id": "C1817458", "aliases": ["gamma-delta T-cell activation during immune response", "gamma-delta T lymphocyte activation during immune response", "gamma-delta T-lymphocyte activation during immune response"], "types": ["T043"], "canonical_name": "gamma-delta T cell activation during immune response"}
{"concept_id": "C1817459", "aliases": ["T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell"], "types": ["T043"], "canonical_name": "T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "definition": "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817460", "aliases": ["T lymphocyte differentiation during immune response", "T-cell differentiation during immune response", "T-lymphocyte differentiation during immune response"], "types": ["T043"], "canonical_name": "T cell differentiation during immune response"}
{"concept_id": "C1817461", "aliases": ["alpha-beta T-lymphocyte differentiation during immune response", "alpha-beta T-cell differentiation during immune response", "alpha-beta T lymphocyte differentiation during immune response"], "types": ["T043"], "canonical_name": "alpha-beta T cell differentiation during immune response"}
{"concept_id": "C1817462", "aliases": ["CD4-positive, alpha-beta T lymphocyte differentiation during immune response", "CD4-positive, alpha-beta T-cell differentiation during immune response", "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response"], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta T cell differentiation during immune response"}
{"concept_id": "C1817463", "aliases": [], "types": ["T043"], "canonical_name": "ensheathment of neurons", "definition": "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. [GOC:dgh, GOC:dph, GOC:tb]"}
{"concept_id": "C1817464", "aliases": [], "types": ["T042"], "canonical_name": "multicellular organism development", "definition": "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]"}
{"concept_id": "C1817465", "aliases": [], "types": ["T043"], "canonical_name": "primordial germ cell development"}
{"concept_id": "C1817466", "aliases": [], "types": ["T040"], "canonical_name": "zygote biosynthesis"}
{"concept_id": "C1817467", "aliases": [], "types": ["T043"], "canonical_name": "ZPG binding"}
{"concept_id": "C1817468", "aliases": [], "types": ["T042"], "canonical_name": "tripartite regional subdivision", "definition": "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C1817469", "aliases": [], "types": ["T042"], "canonical_name": "pattern specification process", "definition": "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]"}
{"concept_id": "C1817470", "aliases": [], "types": ["T042"], "canonical_name": "pattern biosynthesis"}
{"concept_id": "C1817471", "aliases": [], "types": ["T042"], "canonical_name": "defasciculation of motor neuron axon", "definition": "Separation of a motor axon away from a bundle of axons known as a fascicle. [GOC:dgh]"}
{"concept_id": "C1817472", "aliases": [], "types": ["T040"], "canonical_name": "antennal development", "definition": "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli. [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526]"}
{"concept_id": "C1817473", "aliases": [], "types": ["T042"], "canonical_name": "notum development", "definition": "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1817474", "aliases": [], "types": ["T038"], "canonical_name": "imaginal disc-derived genitalia development", "definition": "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster. [GOC:ai, GOC:sensu]"}
{"concept_id": "C1817475", "aliases": [], "types": ["T038"], "canonical_name": "imaginal disc-derived male genitalia development", "definition": "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster. [GOC:ai, GOC:sensu]"}
{"concept_id": "C1817476", "aliases": [], "types": ["T038"], "canonical_name": "imaginal disc-derived female genitalia development", "definition": "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster. [GOC:ai, GOC:sensu]"}
{"concept_id": "C1817477", "aliases": [], "types": ["T042"], "canonical_name": "analia development", "definition": "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster. [GOC:ai, GOC:mtg_sensu]"}
{"concept_id": "C1817478", "aliases": ["arthropod blood cell development"], "types": ["T043"], "canonical_name": "hemocyte development", "definition": "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C1817479", "aliases": [], "types": ["T040"], "canonical_name": "homeostasis of number of meristem cells", "definition": "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem. [GOC:isa_complete]"}
{"concept_id": "C1817480", "aliases": ["sense organ boundary specification"], "types": ["T040"], "canonical_name": "sensory organ boundary specification", "definition": "The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained. [GO_REF:0000021]"}
{"concept_id": "C1817481", "aliases": [], "types": ["T042"], "canonical_name": "ocellus development", "definition": "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects. [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]"}
{"concept_id": "C1817482", "aliases": [], "types": ["T044"], "canonical_name": "methylase"}
{"concept_id": "C1817483", "aliases": ["katanin complex location"], "types": ["T026"], "canonical_name": "katanin complex", "definition": "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa). [PMID:10910766]"}
{"concept_id": "C1817485", "aliases": ["cellular axon ensheathment"], "types": ["T043"], "canonical_name": "axon ensheathment", "definition": "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. [GOC:jl, ISBN:0878932437]"}
{"concept_id": "C1817486", "aliases": [], "types": ["T043"], "canonical_name": "cellular nerve ensheathment"}
{"concept_id": "C1817487", "aliases": [], "types": ["T044"], "canonical_name": "manganese superoxide oxidoreductase"}
{"concept_id": "C1817488", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2A4"}
{"concept_id": "C1817489", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP2B19"}
{"concept_id": "C1817490", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP7B1"}
{"concept_id": "C1817491", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP24"}
{"concept_id": "C1817492", "aliases": [], "types": ["T044"], "canonical_name": "ubiquinone biosynthesis methyltransferase activity"}
{"concept_id": "C1817493", "aliases": [], "types": ["T044"], "canonical_name": "ubiquinone biosynthetic process methyltransferase activity"}
{"concept_id": "C1817494", "aliases": [], "types": ["T044"], "canonical_name": "alpha-tocopherol binding"}
{"concept_id": "C1817495", "aliases": ["beta3Gal-Ts activity"], "types": ["T044"], "canonical_name": "beta-1,3-GalTase activity"}
{"concept_id": "C1817498", "aliases": ["multidrug-resistance protein"], "types": ["T044"], "canonical_name": "multidrug resistance exporter"}
{"concept_id": "C1817499", "aliases": [], "types": ["T044"], "canonical_name": "protein transport chaperone"}
{"concept_id": "C1817500", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity"}
{"concept_id": "C1817501", "aliases": [], "types": ["T044"], "canonical_name": "cAMP-dependent protein kinase, intrinsic regulator activity"}
{"concept_id": "C1817504", "aliases": [], "types": ["T044"], "canonical_name": "holo-[peptidyl-carrier protein] synthase activity"}
{"concept_id": "C1817505", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine biosynthetic process"}
{"concept_id": "C1817506", "aliases": [], "types": ["T044"], "canonical_name": "siderochrome metabolic process"}
{"concept_id": "C1817507", "aliases": [], "types": ["T043"], "canonical_name": "cell envelope biosynthetic process"}
{"concept_id": "C1817508", "aliases": [], "types": ["T045"], "canonical_name": "mRNA biosynthetic process"}
{"concept_id": "C1817509", "aliases": [], "types": ["T045"], "canonical_name": "rRNA biosynthetic process"}
{"concept_id": "C1817510", "aliases": [], "types": ["T045"], "canonical_name": "tRNA biosynthetic process"}
{"concept_id": "C1817511", "aliases": ["UV resistance"], "types": ["T043"], "canonical_name": "ultraviolet resistance"}
{"concept_id": "C1817512", "aliases": ["UV tolerance"], "types": ["T043"], "canonical_name": "ultraviolet tolerance"}
{"concept_id": "C1817513", "aliases": [], "types": ["T043"], "canonical_name": "growth regulator"}
{"concept_id": "C1817514", "aliases": [], "types": ["T043"], "canonical_name": "embryonic mitotic cell cycle regulator"}
{"concept_id": "C1817515", "aliases": [], "types": ["T040"], "canonical_name": "embryonic pattern biosynthesis"}
{"concept_id": "C1817516", "aliases": [], "types": ["T043"], "canonical_name": "cell tip growth", "definition": "Growth that occurs specifically at the tip of a cell. [GOC:jid]"}
{"concept_id": "C1817517", "aliases": [], "types": ["T043"], "canonical_name": "cell growth and/or maintenance"}
{"concept_id": "C1817518", "aliases": [], "types": ["T044"], "canonical_name": "alpha-tocopherol biosynthetic process"}
{"concept_id": "C1817519", "aliases": [], "types": ["T040"], "canonical_name": "organ boundary specification between lateral organs and the meristem", "definition": "The process in which boundaries between lateral organs and the meristem is established and maintained. [PMID:12068116]"}
{"concept_id": "C1817520", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of seed dormancy", "definition": "Any process that maintains a seed in a dormant state. [ISBN:9781405139830, PMID:9580097]"}
{"concept_id": "C1817521", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organism aging", "definition": "An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). [GOC:PO_curators]"}
{"concept_id": "C1817522", "aliases": ["tricyclic triterpenoid formation", "tricyclic triterpenoid anabolism", "tricyclic triterpenoid biosynthesis", "tricyclic triterpenoid synthesis"], "types": ["T044"], "canonical_name": "tricyclic triterpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings. [GOC:ct]"}
{"concept_id": "C1817523", "aliases": ["phytate biosynthetic process", "myo-inositol hexakisphosphate formation", "phytate biosynthesis", "myo-inositol hexakisphosphate biosynthesis", "myo-inositol hexakisphosphate anabolism", "myo-inositol hexakisphosphate synthesis"], "types": ["T038"], "canonical_name": "myo-inositol hexakisphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds. [PMID:16107538]"}
{"concept_id": "C1817524", "aliases": [], "types": ["T044"], "canonical_name": "SCF complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex. [GOC:pz]"}
{"concept_id": "C1817525", "aliases": ["response to thiamin", "response to thiamine"], "types": ["T043"], "canonical_name": "response to vitamin B1", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus. [GOC:pz]"}
{"concept_id": "C1817526", "aliases": ["primary ta-siRNA processing", "production of ta-siRNAs involved in RNA interference", "RNA interference, production of ta-siRNAs"], "types": ["T045"], "canonical_name": "ta-siRNA processing", "definition": "A process leading to the generation of a functional trans-acting small interfering RNA (ta-siRNA). ta-siRNAs function like miRNAs to guide cleavage of target mRNAs. [GOC:tb, PMID:16129836, PMID:20687832]"}
{"concept_id": "C1817527", "aliases": [], "types": ["T038"], "canonical_name": "brassinosteroid homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of brassinosteroids within an organism or cell. [PMID:15908602]"}
{"concept_id": "C1817528", "aliases": [], "types": ["T043"], "canonical_name": "response to selenium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion. [GOC:mg]"}
{"concept_id": "C1817529", "aliases": ["OEC (PSII) ASSEMBLY"], "types": ["T044"], "canonical_name": "photosystem II oxygen evolving complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on a thylakoid membrane. The OEC protects the calcium-4 manganese-5 oxide cluster which is bound to the D1 and CP43 proteins. The exact protein composition of the OEC varies between cyanobacteria and plants, and in plants consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ. [GOC:aa, PMID:16282331]"}
{"concept_id": "C1817530", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chlorophyll catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll. [PMID:16361392]"}
{"concept_id": "C1817531", "aliases": [], "types": ["T043"], "canonical_name": "response to silver ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus. [PMID:16367966]"}
{"concept_id": "C1817532", "aliases": [], "types": ["T046"], "canonical_name": "detoxification of copper ion", "definition": "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion. [GOC:kmv, PMID:16367966]"}
{"concept_id": "C1817533", "aliases": [], "types": ["T039"], "canonical_name": "hydrotropism", "definition": "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant. [ISBN:0395825172]"}
{"concept_id": "C1817534", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)H dehydrogenase complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool. [GOC:sm]"}
{"concept_id": "C1817535", "aliases": [], "types": ["T044"], "canonical_name": "phytol kinase activity", "definition": "Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+. [RHEA:38055]"}
{"concept_id": "C1817537", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast outer membrane translocon", "definition": "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner. [PMID:11299338]"}
{"concept_id": "C1817538", "aliases": ["IAA amino acid synthetase activity", "IAA amino acid conjugate synthetase activity", "IAA amido synthetase activity"], "types": ["T044"], "canonical_name": "indole-3-acetic acid amido synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate. [PMID:15659623]"}
{"concept_id": "C1817539", "aliases": ["UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity"], "types": ["T044"], "canonical_name": "UDP-L-rhamnose synthase activity", "definition": "Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O. [MetaCyc:RXN-5482, PMID:14701918]"}
{"concept_id": "C1817541", "aliases": ["senescence associated vacuole"], "types": ["T026"], "canonical_name": "senescence-associated vacuole", "definition": "A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast. [PMID:15743448]"}
{"concept_id": "C1817542", "aliases": [], "types": ["T044"], "canonical_name": "pinoresinol reductase activity", "definition": "Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+. [PMID:10066819, PMID:7592828]"}
{"concept_id": "C1817543", "aliases": [], "types": ["T044"], "canonical_name": "lariciresinol reductase activity", "definition": "Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+. [PMID:10066819, PMID:7592828]"}
{"concept_id": "C1817544", "aliases": ["LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity", "LL-diaminopimelate aminotransferase activity", "LL-DAP aminotransferase activity", "LL-diaminopimelate transaminase activity", "LL-DAP-AT activity"], "types": ["T044"], "canonical_name": "L,L-diaminopimelate aminotransferase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H(2)O + H(+). [EC:2.6.1.83, RHEA:23988]"}
{"concept_id": "C1817545", "aliases": [], "types": ["T039"], "canonical_name": "heat acclimation", "definition": "Any process that increases heat tolerance of an organism in response to high temperatures. [GOC:tair_curators]"}
{"concept_id": "C1817546", "aliases": ["PG", "plastoglobuli"], "types": ["T026"], "definition": "A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids. [GOC:tair_curators, PMID:16461379]", "canonical_name": "plastoglobule"}
{"concept_id": "C1817547", "aliases": [], "types": ["T043"], "canonical_name": "response to lead ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. [GOC:tair_curators, PMID:16461380]"}
{"concept_id": "C1817548", "aliases": [], "types": ["T044"], "canonical_name": "homogalacturonan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of (1->4)-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. [PMID:12913136, PMID:16540543]"}
{"concept_id": "C1817550", "aliases": ["carotene beta-ring hydroxylase activity"], "types": ["T044"], "canonical_name": "carotene beta-ring hydroxylase activity", "definition": "Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene. [MetaCyc:MONOMER-12386, PMID:16492736]"}
{"concept_id": "C1817551", "aliases": [], "types": ["T044"], "canonical_name": "GTP:GDP antiporter activity", "definition": "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out). [PMID:10514379, PMID:12553910, PMID:16553903]"}
{"concept_id": "C1817552", "aliases": ["abscisic-aldehyde oxidase activity", "AAO3", "abscisic-aldehyde:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "abscisic aldehyde oxidase activity", "definition": "Catalysis of the reaction: (+)-abscisic aldehyde + H(2)O + O(2) = abscisate + H(2)O(2) + H(+). [EC:1.2.3.14, RHEA:20529]"}
{"concept_id": "C1817553", "aliases": [], "types": ["T044"], "canonical_name": "abscisic acid glucosyltransferase activity", "definition": "Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP. [DOI:10.1016/j.tetasy.2004.11.062]"}
{"concept_id": "C1817554", "aliases": ["ABA 8'-hydroxylase activity", "abscisic acid 8'-hydroxylase activity", "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)", "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity", "(+)-ABA 8'-hydroxylase activity"], "types": ["T044"], "canonical_name": "(+)-abscisic acid 8'-hydroxylase activity", "definition": "Catalysis of the reaction: (+)-abscisate + H(+) + NADPH + O(2) = (+)-8'-hydroxyabscisate + H(2)O + NADP(+). [EC:1.14.14.137, RHEA:12897]"}
{"concept_id": "C1817555", "aliases": [], "types": ["T044"], "canonical_name": "prenylcysteine methylesterase activity", "definition": "Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+. [PMID:16870359, RHEA:48520]"}
{"concept_id": "C1817556", "aliases": ["heteroglycan binding"], "types": ["T044"], "canonical_name": "heteropolysaccharide binding", "definition": "Binding to a heteropolysaccharide, a glycan composed of more than one type of monosaccharide residue. [PMID:16640603]"}
{"concept_id": "C1817557", "aliases": [], "types": ["T044"], "canonical_name": "dihydrocamalexic acid decarboxylase activity", "definition": "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+. [MetaCyc:RXN-8275, PMID:16766671]"}
{"concept_id": "C1817558", "aliases": [], "types": ["T046"], "canonical_name": "detoxification of cobalt ion", "definition": "Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion. [GOC:tair_curators]"}
{"concept_id": "C1817560", "aliases": ["xanthoxin:NAD+ oxidoreductase activity", "xanthoxin oxidase activity", "ABA2"], "types": ["T044"], "canonical_name": "xanthoxin dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(+) + xanthoxin = (+)-abscisic aldehyde + H(+) + NADH. [EC:1.1.1.288, RHEA:12548]"}
{"concept_id": "C1817563", "aliases": [], "types": ["T043"], "canonical_name": "PSII associated light-harvesting complex II catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II. [GOC:mah, PMID:16157880]"}
{"concept_id": "C1817564", "aliases": [], "types": ["T043"], "canonical_name": "LHCII catabolism"}
{"concept_id": "C1817565", "aliases": [], "types": ["T040"], "canonical_name": "leaf vascular tissue pattern formation", "definition": "Vascular tissue pattern formation as it occurs in the leaf of vascular plants. [GOC:tair_curators]"}
{"concept_id": "C1817566", "aliases": [], "types": ["T044"], "canonical_name": "rhamnogalacturonan II biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms. [PMID:12754267]"}
{"concept_id": "C1817567", "aliases": [], "types": ["T044"], "canonical_name": "acetylglutamate kinase regulator activity", "definition": "Modulates the enzyme activity of acetylglutamate kinase. [PMID:16377628]"}
{"concept_id": "C1817568", "aliases": ["E-2 activity", "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)"], "types": ["T044"], "canonical_name": "acireductone dioxygenase (Ni2+-requiring) activity", "definition": "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + CO + formate. [EC:1.13.11.53, RHEA:14161]"}
{"concept_id": "C1817569", "aliases": ["acireductone dioxygenase (Fe2+-requiring) activity", "E-2'", "acireductone dioxygenase [iron(II)-requiring] activity", "ARD1", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity", "ARD'"], "types": ["T044"], "definition": "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+). [EC:1.13.11.54, RHEA:24504]", "canonical_name": "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)"}
{"concept_id": "C1817570", "aliases": ["regulation of hydrogen peroxide metabolism"], "types": ["T040"], "canonical_name": "regulation of hydrogen peroxide metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. [PMID:14765119]"}
{"concept_id": "C1817571", "aliases": ["lateral root primordium development"], "types": ["T040"], "canonical_name": "lateral root formation", "definition": "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper. [GOC:tair_curators, PMID:17259263]"}
{"concept_id": "C1817572", "aliases": [], "types": ["T046"], "canonical_name": "detoxification of zinc ion", "definition": "Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion. [GOC:tair_curators]"}
{"concept_id": "C1817573", "aliases": [], "types": ["T044"], "canonical_name": "phytochrome binding", "definition": "Binding to a phytochrome. [PMID:15486102]"}
{"concept_id": "C1817574", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-5-phosphate binding", "definition": "Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. [GOC:bf, GOC:tair_curators]"}
{"concept_id": "C1817575", "aliases": ["auxin export"], "types": ["T043"], "canonical_name": "auxin efflux"}
{"concept_id": "C1817576", "aliases": ["pyrophosphate-dependent phosphofructokinase complex location"], "types": ["T026"], "canonical_name": "pyrophosphate-dependent phosphofructokinase complex", "definition": "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate. [PMID:2170409]"}
{"concept_id": "C1817577", "aliases": ["PFK complex location"], "types": ["T026"], "canonical_name": "PFK complex"}
{"concept_id": "C1817578", "aliases": ["pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex location"], "types": ["T026"], "canonical_name": "pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex", "definition": "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity. [PMID:2170409]"}
{"concept_id": "C1817579", "aliases": ["PFK complex location, alpha-subunit"], "types": ["T026"], "canonical_name": "PFK complex, alpha-subunit"}
{"concept_id": "C1817580", "aliases": ["pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex location"], "types": ["T026"], "canonical_name": "pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex", "definition": "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity. [PMID:2170409]"}
{"concept_id": "C1817581", "aliases": ["PFK complex location, beta-subunit"], "types": ["T026"], "canonical_name": "PFK complex, beta-subunit"}
{"concept_id": "C1817582", "aliases": [], "types": ["T026"], "canonical_name": "stromule", "definition": "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types. [PMID:15272881, PMID:15699062, PMID:16582010]"}
{"concept_id": "C1817583", "aliases": [], "types": ["T026"], "canonical_name": "Stroma-filled tubule"}
{"concept_id": "C1817585", "aliases": [], "types": ["T040"], "canonical_name": "regulation of vegetative phase change", "definition": "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development. [GOC:tair_curators]"}
{"concept_id": "C1817586", "aliases": ["regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway"], "types": ["T044"], "canonical_name": "regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent). [PMID:16531478]"}
{"concept_id": "C1817587", "aliases": ["down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway", "negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway", "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway", "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway"], "types": ["T044"], "canonical_name": "negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent). [PMID:16531478]"}
{"concept_id": "C1817588", "aliases": [], "types": ["T043"], "canonical_name": "membrane invagination", "definition": "The infolding of a membrane. [GOC:tb]"}
{"concept_id": "C1817589", "aliases": ["raffinose family oligosaccharide biosynthesis"], "types": ["T044"], "canonical_name": "raffinose family oligosaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization). [GOC:tair_curators]"}
{"concept_id": "C1817590", "aliases": [], "types": ["T044"], "canonical_name": "methionine-oxo-acid transaminase activity", "definition": "Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid. [MetaCyc:RXN-2201, PMID:17056707]"}
{"concept_id": "C1817591", "aliases": [], "types": ["T044"], "canonical_name": "acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate. [PMID:17163883]"}
{"concept_id": "C1817592", "aliases": [], "types": ["T044"], "canonical_name": "hexenol acetyltransferase"}
{"concept_id": "C1817594", "aliases": [], "types": ["T044"], "canonical_name": "auxin influx facilitator"}
{"concept_id": "C1817596", "aliases": [], "types": ["T044"], "canonical_name": "auxin efflux carrier"}
{"concept_id": "C1817597", "aliases": [], "types": ["T044"], "canonical_name": "auxin efflux facilitator"}
{"concept_id": "C1817598", "aliases": ["CESA complex location", "cellulose synthase complex location", "CESA complex"], "types": ["T026"], "canonical_name": "cellulose synthase complex", "definition": "A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall. [PMID:12514238, PMID:18485800, PMID:21307367]"}
{"concept_id": "C1817599", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin binding", "definition": "Binding to a gibberellin, a plant hormone that regulates aspects of plant growth. [GOC:tair_curators]"}
{"concept_id": "C1817600", "aliases": [], "types": ["T044"], "canonical_name": "gibberellic acid receptor"}
{"concept_id": "C1817601", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin receptor"}
{"concept_id": "C1817603", "aliases": [], "types": ["T043"], "canonical_name": "sclerenchyma cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable. [CL:0000276, GOC:ef, GOC:jid, PO:0000077]"}
{"concept_id": "C1817604", "aliases": ["astrocyte cell development"], "types": ["T043"], "canonical_name": "astrocyte development", "definition": "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. [GOC:dgh, GOC:ef]"}
{"concept_id": "C1817605", "aliases": ["oligodendrocyte cell development"], "types": ["T043"], "canonical_name": "oligodendrocyte development", "definition": "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. [GOC:dgh, GOC:ef]"}
{"concept_id": "C1817606", "aliases": ["microglial cell differentiation"], "types": ["T043"], "canonical_name": "microglia differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system. [GOC:ef]"}
{"concept_id": "C1817607", "aliases": ["microglial cell development"], "types": ["T043"], "canonical_name": "microglia development", "definition": "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dgh, GOC:ef]"}
{"concept_id": "C1817608", "aliases": ["regulation of microglial cell differentiation"], "types": ["T043"], "canonical_name": "regulation of microglia differentiation", "definition": "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell. [GOC:ef]"}
{"concept_id": "C1817609", "aliases": ["negative regulation of microglial cell differentiation", "downregulation of microglia differentiation", "down regulation of microglia differentiation", "down-regulation of microglia differentiation"], "types": ["T043"], "canonical_name": "negative regulation of microglia differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell. [GOC:ef]"}
{"concept_id": "C1817610", "aliases": ["up regulation of microglia differentiation", "positive regulation of microglial cell differentiation", "up-regulation of microglia differentiation", "upregulation of microglia differentiation"], "types": ["T043"], "canonical_name": "positive regulation of microglia differentiation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell. [GOC:ef]"}
{"concept_id": "C1817611", "aliases": [], "types": ["T043"], "canonical_name": "Schwann cell proliferation", "definition": "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. [GOC:ef, ISBN:0878932585]"}
{"concept_id": "C1817612", "aliases": [], "types": ["T043"], "canonical_name": "Schwann cell proliferation involved in axon regeneration", "definition": "The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system. [GOC:ef, ISBN:0878932585]"}
{"concept_id": "C1817613", "aliases": ["axon regeneration in peripheral nervous system"], "types": ["T042"], "canonical_name": "peripheral nervous system axon regeneration", "definition": "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury. [GOC:ef]"}
{"concept_id": "C1817614", "aliases": [], "types": ["T038"], "canonical_name": "regulation of gliogenesis", "definition": "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. [GOC:ef]"}
{"concept_id": "C1817615", "aliases": ["downregulation of gliogenesis", "down-regulation of gliogenesis", "down regulation of gliogenesis"], "types": ["T039"], "canonical_name": "negative regulation of gliogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. [GOC:ef]"}
{"concept_id": "C1817616", "aliases": ["up regulation of gliogenesis", "upregulation of gliogenesis", "up-regulation of gliogenesis"], "types": ["T039"], "canonical_name": "positive regulation of gliogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. [GOC:ef]"}
{"concept_id": "C1817617", "aliases": [], "types": ["T043"], "canonical_name": "neuroblast differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. [GOC:ef, ISBN:0878932585]"}
{"concept_id": "C1817618", "aliases": [], "types": ["T043"], "canonical_name": "neuroblast fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast. [GOC:ef, ISBN:0878932585]"}
{"concept_id": "C1817619", "aliases": [], "types": ["T043"], "canonical_name": "neuroblast fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [GOC:ef, ISBN:0878932585]"}
{"concept_id": "C1817620", "aliases": [], "types": ["T043"], "canonical_name": "neuroblast development", "definition": "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. [GOC:ef, ISBN:0878932585]"}
{"concept_id": "C1817621", "aliases": ["primary neural tube morphogenesis", "primary neural tube formation"], "types": ["T040"], "definition": "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. [GOC:ef, ISBN:0878932585, PMID:15327780]", "canonical_name": "primary neurulation"}
{"concept_id": "C1817622", "aliases": ["medullary cord formation", "medullary cord biosynthesis", "secondary neurulation", "neural rod formation"], "types": ["T040"], "definition": "The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals. [GOC:ef, ISBN:0878932585, PMID:15327780]", "canonical_name": "secondary neural tube formation"}
{"concept_id": "C1817624", "aliases": [], "types": ["T040"], "canonical_name": "neural plate elongation", "definition": "The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions. [GOC:ef, ISBN:0878932585]"}
{"concept_id": "C1817625", "aliases": [], "types": ["T040"], "definition": "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. [GOC:dh, GOC:ef]", "canonical_name": "neural rod formation"}
{"concept_id": "C1817627", "aliases": [], "types": ["T040"], "canonical_name": "neural keel formation", "definition": "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817629", "aliases": [], "types": ["T040"], "canonical_name": "notochord formation", "definition": "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817630", "aliases": [], "types": ["T043"], "canonical_name": "neural crest formation", "definition": "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817631", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell fate commitment", "definition": "The process in which a cell becomes committed to become a mesenchymal cell. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817632", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell development", "definition": "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817633", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell development", "definition": "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817634", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817635", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell fate commitment", "definition": "The process in which a cell becomes committed to become a neural crest cell. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817636", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817637", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:dh, GOC:ef]"}
{"concept_id": "C1817638", "aliases": [], "types": ["T043"], "canonical_name": "Schwann cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. [GOC:ef]"}
{"concept_id": "C1817639", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Schwann cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of Schwann cell differentiation. [GOC:ef]"}
{"concept_id": "C1817640", "aliases": ["down regulation of Schwann cell differentiation", "down-regulation of Schwann cell differentiation", "downregulation of Schwann cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of Schwann cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation. [GOC:ef]"}
{"concept_id": "C1817641", "aliases": ["up regulation of Schwann cell differentiation", "upregulation of Schwann cell differentiation", "up-regulation of Schwann cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of Schwann cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation. [GOC:ef]"}
{"concept_id": "C1817642", "aliases": [], "types": ["T038"], "canonical_name": "regulation of neuron maturation", "definition": "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. [GOC:ef]"}
{"concept_id": "C1817643", "aliases": ["up regulation of neuron maturation", "up-regulation of neuron maturation", "upregulation of neuron maturation"], "types": ["T039"], "canonical_name": "positive regulation of neuron maturation", "definition": "Any process that activates or increases the frequency, rate or extent of neuron maturation. [GOC:ef]"}
{"concept_id": "C1817644", "aliases": ["down regulation of neuron maturation", "down-regulation of neuron maturation", "downregulation of neuron maturation"], "types": ["T039"], "canonical_name": "negative regulation of neuron maturation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. [GOC:ef]"}
{"concept_id": "C1817645", "aliases": [], "types": ["T043"], "canonical_name": "Schwann cell development", "definition": "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. [GOC:dgh, GOC:ef]"}
{"concept_id": "C1817647", "aliases": [], "types": ["T042"], "canonical_name": "dopamine secretion", "definition": "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone. [GOC:ef]"}
{"concept_id": "C1817648", "aliases": [], "types": ["T043"], "canonical_name": "glutamate secretion", "definition": "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. [GOC:ef]"}
{"concept_id": "C1817649", "aliases": [], "types": ["T038"], "canonical_name": "regulation of glutamate secretion", "definition": "Any process that modulates the frequency, rate or extent of the controlled release of glutamate. [GOC:ef]"}
{"concept_id": "C1817650", "aliases": ["upregulation of glutamate secretion", "up regulation of glutamate secretion", "up-regulation of glutamate secretion"], "types": ["T043"], "canonical_name": "positive regulation of glutamate secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate. [GOC:ef]"}
{"concept_id": "C1817651", "aliases": ["downregulation of glutamate secretion", "down regulation of glutamate secretion", "down-regulation of glutamate secretion"], "types": ["T043"], "canonical_name": "negative regulation of glutamate secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate. [GOC:ef]"}
{"concept_id": "C1817652", "aliases": ["GABA secretion"], "types": ["T043"], "canonical_name": "gamma-aminobutyric acid secretion", "definition": "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues. [GOC:ef]"}
{"concept_id": "C1817653", "aliases": ["regulation of GABA secretion"], "types": ["T043"], "canonical_name": "regulation of gamma-aminobutyric acid secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. [GOC:ef]"}
{"concept_id": "C1817654", "aliases": ["downregulation of gamma-aminobutyric acid secretion", "negative regulation of GABA secretion", "down-regulation of gamma-aminobutyric acid secretion", "down regulation of gamma-aminobutyric acid secretion"], "types": ["T043"], "canonical_name": "negative regulation of gamma-aminobutyric acid secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. [GOC:ef]"}
{"concept_id": "C1817655", "aliases": ["up regulation of gamma-aminobutyric acid secretion", "positive regulation of GABA secretion", "up-regulation of gamma-aminobutyric acid secretion", "upregulation of gamma-aminobutyric acid secretion"], "types": ["T043"], "canonical_name": "positive regulation of gamma-aminobutyric acid secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. [GOC:ef]"}
{"concept_id": "C1817656", "aliases": [], "types": ["T043"], "canonical_name": "acetylcholine secretion, neurotransmission", "definition": "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS). [GOC:ef]"}
{"concept_id": "C1817657", "aliases": [], "types": ["T043"], "canonical_name": "regulation of acetylcholine secretion, neurotransmission", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine. [GOC:ef]"}
{"concept_id": "C1817658", "aliases": ["upregulation of acetylcholine secretion", "up regulation of acetylcholine secretion", "up-regulation of acetylcholine secretion"], "types": ["T043"], "canonical_name": "positive regulation of acetylcholine secretion, neurotransmission", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine. [GOC:ef]"}
{"concept_id": "C1817659", "aliases": ["down regulation of acetylcholine secretion", "down-regulation of acetylcholine secretion", "downregulation of acetylcholine secretion"], "types": ["T043"], "canonical_name": "negative regulation of acetylcholine secretion, neurotransmission", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine. [GOC:ef]"}
{"concept_id": "C1817660", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dopamine secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of dopamine. [GOC:ef]"}
{"concept_id": "C1817661", "aliases": ["regulation of adrenaline secretion"], "types": ["T043"], "canonical_name": "regulation of epinephrine secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine. [GOC:ef]"}
{"concept_id": "C1817662", "aliases": ["regulation of noradrenaline secretion"], "types": ["T043"], "canonical_name": "regulation of norepinephrine secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. [GOC:ef]"}
{"concept_id": "C1817663", "aliases": ["regulation of serotonin release"], "types": ["T043"], "canonical_name": "regulation of serotonin secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of serotonin. [GOC:ef]"}
{"concept_id": "C1817664", "aliases": ["down regulation of serotonin secretion", "down-regulation of serotonin secretion", "downregulation of serotonin secretion"], "types": ["T043"], "canonical_name": "negative regulation of serotonin secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. [GOC:ef]"}
{"concept_id": "C1817665", "aliases": ["up regulation of serotonin secretion", "up-regulation of serotonin secretion", "upregulation of serotonin secretion"], "types": ["T043"], "canonical_name": "positive regulation of serotonin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. [GOC:ef]"}
{"concept_id": "C1817666", "aliases": ["phosphatidylinositol 3-kinase cascade", "phosphoinositide 3-kinase cascade", "PI3K signaling", "PI3K cascade", "phosphatidylinositol 3-kinase signal transduction", "PI 3-kinase cascade", "PI3K signal transduction"], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase signaling", "definition": "A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. [GOC:ef, http://www.biocarta.com, PMID:22525052, Wikipedia:PI3K]"}
{"concept_id": "C1817667", "aliases": ["regulation of phosphatidylinositol 3-kinase cascade", "regulation of phosphoinositide 3-kinase cascade", "regulation of PI3K cascade"], "types": ["T038"], "canonical_name": "regulation of phosphatidylinositol 3-kinase signaling", "definition": "Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. [GOC:ef]"}
{"concept_id": "C1817668", "aliases": [], "types": ["T038"], "canonical_name": "regulation of PI 3-kinase cascade"}
{"concept_id": "C1817669", "aliases": ["negative regulation of PI3K cascade", "down regulation of phosphatidylinositol 3-kinase cascade", "downregulation of phosphatidylinositol 3-kinase cascade", "negative regulation of phosphatidylinositol 3-kinase cascade", "negative regulation of PI 3-kinase cascade", "down-regulation of phosphatidylinositol 3-kinase cascade", "negative regulation of phosphoinositide 3-kinase cascade"], "types": ["T038"], "canonical_name": "negative regulation of phosphatidylinositol 3-kinase signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. [GOC:ef]"}
{"concept_id": "C1817670", "aliases": ["positive regulation of PI3K cascade", "upregulation of phosphatidylinositol 3-kinase cascade", "positive regulation of PI 3-kinase cascade", "positive regulation of phosphoinositide 3-kinase cascade", "up-regulation of phosphatidylinositol 3-kinase cascade", "up regulation of phosphatidylinositol 3-kinase cascade", "positive regulation of phosphatidylinositol 3-kinase cascade"], "types": ["T038"], "canonical_name": "positive regulation of phosphatidylinositol 3-kinase signaling", "definition": "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. [GOC:ef]"}
{"concept_id": "C1817671", "aliases": ["neuronal postsynaptic density", "post-synaptic density", "postsynaptic density"], "types": ["T026"], "definition": "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]", "canonical_name": "post synaptic density"}
{"concept_id": "C1817673", "aliases": ["T-helper cell fate commitment"], "types": ["T043"], "canonical_name": "T-helper cell lineage commitment", "definition": "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817674", "aliases": [], "types": ["T043"], "canonical_name": "Th0 lineage commitment"}
{"concept_id": "C1817675", "aliases": [], "types": ["T043"], "canonical_name": "Thp lineage commitment"}
{"concept_id": "C1817676", "aliases": ["Th1 cell lineage commitment", "Th1 fate commitment", "T-helper 1 cell fate commitment"], "types": ["T043"], "canonical_name": "T-helper 1 cell lineage commitment", "definition": "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817677", "aliases": ["T-helper 2 cell fate commitment", "Th2 fate commitment"], "types": ["T043"], "canonical_name": "T-helper 2 cell lineage commitment", "definition": "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817678", "aliases": ["CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response", "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response", "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response"], "types": ["T043"], "canonical_name": "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response"}
{"concept_id": "C1817679", "aliases": ["alpha-beta intraepithelial T lymphocyte differentiation", "alpha-beta intraepithelial T-lymphocyte differentiation", "alpha-beta intraepithelial T-cell differentiation"], "types": ["T043"], "canonical_name": "alpha-beta intraepithelial T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817680", "aliases": ["CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation", "CD8-positive, alpha-beta intraepithelial T-cell differentiation", "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta intraepithelial T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817681", "aliases": ["CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation", "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation", "CD4-positive, alpha-beta intraepithelial T-cell differentiation"], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta intraepithelial T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817682", "aliases": ["CD8-positive, alpha-beta T-lymphocyte differentiation during immune response", "CD8-positive, alpha-beta T lymphocyte differentiation during immune response", "CD8-positive, alpha-beta T-cell differentiation during immune response"], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta T cell differentiation during immune response"}
{"concept_id": "C1817683", "aliases": ["gamma-delta T-lymphocyte differentiation during immune response", "gamma-delta T lymphocyte differentiation during immune response", "gamma-delta T-cell differentiation during immune response"], "types": ["T043"], "canonical_name": "gamma-delta T cell differentiation during immune response"}
{"concept_id": "C1817684", "aliases": ["gamma-delta intraepithelial T-cell differentiation", "gamma-delta intraepithelial T lymphocyte differentiation", "gamma-delta intraepithelial T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "gamma-delta intraepithelial T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817685", "aliases": ["CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation", "CD8-positive, gamma-delta intraepithelial T-cell differentiation", "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "CD8-positive, gamma-delta intraepithelial T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817686", "aliases": ["CD4-positive, gamma-delta intraepithelial T-cell differentiation", "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation", "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "CD4-positive gamma-delta intraepithelial T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817687", "aliases": ["CD8-positive, alpha-beta regulatory T-cell differentiation", "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation", "CD8-positive, alpha-beta regulatory T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta regulatory T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817688", "aliases": ["CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation", "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation", "CD8-positive, alpha-beta cytotoxic T-cell differentiation"], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta cytotoxic T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817689", "aliases": ["T-lymphocyte proliferation during immune response", "T lymphocyte proliferation during immune response", "T-cell proliferation during immune response"], "types": ["T043"], "canonical_name": "T cell proliferation during immune response"}
{"concept_id": "C1817690", "aliases": ["alpha-beta T-lymphocyte proliferation during immune response", "alpha-beta T lymphocyte proliferation during immune response", "alpha-beta T-cell proliferation during immune response"], "types": ["T043"], "canonical_name": "alpha-beta T cell proliferation during immune response"}
{"concept_id": "C1817691", "aliases": ["gamma-delta T-cell proliferation during immune response", "gamma-delta T lymphocyte proliferation during immune response", "gamma-delta T-lymphocyte proliferation during immune response"], "types": ["T043"], "canonical_name": "gamma-delta T cell proliferation during immune response"}
{"concept_id": "C1817692", "aliases": ["B-lymphocyte activation during immune response", "B lymphocyte activation during immune response", "B-cell activation during immune response"], "types": ["T043"], "canonical_name": "B cell activation during immune response"}
{"concept_id": "C1817693", "aliases": ["mature B-lymphocyte differentiation during immune response", "mature B-cell differentiation during immune response", "mature B lymphocyte differentiation during immune response"], "types": ["T043"], "canonical_name": "mature B cell differentiation during immune response"}
{"concept_id": "C1817694", "aliases": ["germinal center B-cell differentiation", "germinal center B-lymphocyte differentiation", "germinal center B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "germinal center B cell differentiation", "definition": "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA). [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817695", "aliases": ["marginal zone B-lymphocyte differentiation", "marginal zone B-cell differentiation", "marginal zone B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "marginal zone B cell differentiation", "definition": "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817696", "aliases": ["follicular B-cell differentiation", "follicular B lymphocyte differentiation", "follicular B-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "follicular B cell differentiation", "definition": "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817697", "aliases": [], "types": ["T043"], "canonical_name": "plasma cell differentiation", "definition": "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody. [GOC:jal]"}
{"concept_id": "C1817698", "aliases": [], "types": ["T043"], "canonical_name": "myeloid progenitor cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. [GOC:add, PMID:16551264]"}
{"concept_id": "C1817699", "aliases": ["memory B lymphocyte differentiation", "memory B-cell differentiation", "memory B-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "memory B cell differentiation", "definition": "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817700", "aliases": [], "types": ["T043"], "canonical_name": "lymphoid progenitor cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. [GOC:add, PMID:16551251, PMID:16551264]"}
{"concept_id": "C1817701", "aliases": [], "types": ["T043"], "canonical_name": "natural killer cell progenitor differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor. [GOC:add, PMID:16551251, PMID:16551264]"}
{"concept_id": "C1817702", "aliases": ["B-cell proliferation during immune response", "B-lymphocyte proliferation during immune response", "B lymphocyte proliferation during immune response"], "types": ["T043"], "canonical_name": "B cell proliferation during immune response"}
{"concept_id": "C1817703", "aliases": ["NK cell activation during immune response"], "types": ["T043"], "canonical_name": "natural killer cell activation during immune response"}
{"concept_id": "C1817704", "aliases": ["NK cell proliferation during immune response"], "types": ["T043"], "canonical_name": "natural killer cell proliferation during immune response"}
{"concept_id": "C1817705", "aliases": ["NK cell differentiation during immune response"], "types": ["T043"], "canonical_name": "natural killer cell differentiation during immune response"}
{"concept_id": "C1817706", "aliases": ["B-lymphocyte lineage commitment", "B lymphocyte lineage commitment", "B-cell lineage commitment"], "types": ["T043"], "canonical_name": "B cell lineage commitment", "definition": "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817707", "aliases": ["immature B-lymphocyte differentiation", "immature B-cell differentiation", "immature B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "immature B cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of an immature B cell. [GOC:jal, ISBN:0781735149, PMID:16551251]"}
{"concept_id": "C1817708", "aliases": ["pro-B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "pro-B cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817709", "aliases": ["pre-B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "pre-B cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817710", "aliases": [], "types": ["T043"], "canonical_name": "pre-B cell receptor expression", "definition": "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell. [GOC:add, GOC:jal, PMID:15263090, PMID:22949502, PMID:9834086]"}
{"concept_id": "C1817711", "aliases": ["pre-B lymphocyte allelic exclusion"], "types": ["T043"], "canonical_name": "pre-B cell allelic exclusion", "definition": "Expression of a single heavy chain allele during pre-B cell differentiation. [GOC:add, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817712", "aliases": ["transitional stage B-cell differentiation", "transitional stage B-lymphocyte differentiation", "transitional stage B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "transitional stage B cell differentiation", "definition": "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817713", "aliases": ["transitional one stage B-lymphocyte differentiation", "transitional one stage B-cell differentiation", "T1 stage B cell differentiation", "transitional one stage B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "transitional one stage B cell differentiation", "definition": "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817714", "aliases": ["transitional two stage B-cell differentiation", "transitional two stage B-lymphocyte differentiation", "transitional two stage B lymphocyte differentiation", "T2 stage B cell differentiation"], "types": ["T043"], "canonical_name": "transitional two stage B cell differentiation", "definition": "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817715", "aliases": ["mature B lymphocyte differentiation", "mature B-cell differentiation", "mature B-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "mature B cell differentiation", "definition": "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817716", "aliases": ["B-1 B-lymphocyte lineage commitment", "B-1 B-cell lineage commitment", "B-1 B lymphocyte lineage commitment"], "types": ["T043"], "canonical_name": "B-1 B cell lineage commitment", "definition": "The process in which an immature B cell becomes committed to become a B-1 B cell. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817717", "aliases": ["B-1a B lymphocyte differentiation", "B-1a B-cell differentiation", "B-1a B-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "B-1a B cell differentiation", "definition": "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817718", "aliases": ["B-1b B-cell differentiation", "B-1b B lymphocyte differentiation", "B-1b B-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "B-1b B cell differentiation", "definition": "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817719", "aliases": ["B-lymphocyte selection", "B lymphocyte selection", "B-cell selection"], "types": ["T038"], "canonical_name": "B cell selection", "definition": "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival. [GOC:jal]"}
{"concept_id": "C1817720", "aliases": ["central B-cell selection", "central B-lymphocyte selection", "central B lymphocyte selection"], "types": ["T038"], "canonical_name": "central B cell selection", "definition": "Any B cell selection process that occurs in the bone marrow. [GOC:jal]"}
{"concept_id": "C1817721", "aliases": ["central B lymphocyte anergy", "central B-cell anergy", "central B-lymphocyte anergy"], "types": ["T038"], "canonical_name": "central B cell anergy", "definition": "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow. [GOC:jal]"}
{"concept_id": "C1817722", "aliases": ["central B lymphocyte deletion", "central B-cell deletion", "central B-lymphocyte deletion"], "types": ["T043"], "canonical_name": "central B cell deletion", "definition": "The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection. [GOC:add, GOC:jal, GOC:mtg_apoptosis]"}
{"concept_id": "C1817723", "aliases": ["peripheral B-cell selection", "peripheral B lymphocyte selection", "peripheral B-lymphocyte selection"], "types": ["T038"], "canonical_name": "peripheral B cell selection", "definition": "Any B cell selection process that occurs in the periphery. [GOC:jal]"}
{"concept_id": "C1817724", "aliases": ["B-lymphocyte affinity maturation", "B lymphocyte affinity maturation", "B-cell affinity maturation"], "types": ["T038"], "canonical_name": "B cell affinity maturation", "definition": "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817725", "aliases": ["peripheral B-cell receptor editing", "peripheral B lymphocyte receptor editing", "peripheral B-lymphocyte receptor editing"], "types": ["T045"], "canonical_name": "peripheral B cell receptor editing", "definition": "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation. [GOC:jal]"}
{"concept_id": "C1817726", "aliases": ["B-lymphocyte positive selection", "B lymphocyte positive selection", "B-cell positive selection"], "types": ["T038"], "canonical_name": "B cell positive selection", "definition": "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor. [GOC:jal]"}
{"concept_id": "C1817727", "aliases": [], "types": ["T040"], "canonical_name": "response to tumor cell", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C1817728", "aliases": ["central B-cell positive selection", "central B-lymphocyte positive selection", "central B lymphocyte positive selection"], "types": ["T038"], "canonical_name": "central B cell positive selection", "definition": "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors. [GOC:jal]"}
{"concept_id": "C1817730", "aliases": ["peripheral B lymphocyte positive selection", "peripheral B-lymphocyte positive selection", "peripheral B-cell positive selection"], "types": ["T038"], "canonical_name": "peripheral B cell positive selection", "definition": "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors. [GOC:jal]"}
{"concept_id": "C1817732", "aliases": ["B-cell negative selection", "B-lymphocyte negative selection", "B lymphocyte negative selection"], "types": ["T038"], "canonical_name": "B cell negative selection", "definition": "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion. [GOC:jal]"}
{"concept_id": "C1817733", "aliases": [], "types": ["T046"], "canonical_name": "plasma kallikrein-kinin cascade", "definition": "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145]"}
{"concept_id": "C1817734", "aliases": ["central B-lymphocyte negative selection", "central B lymphocyte negative selection", "central B-cell negative selection"], "types": ["T038"], "canonical_name": "central B cell negative selection", "definition": "Any process leading to negative selection of B cells in the bone marrow. [GOC:jal]"}
{"concept_id": "C1817735", "aliases": [], "types": ["T043"], "canonical_name": "detection of tumor cell", "definition": "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C1817736", "aliases": ["peripheral B lymphocyte negative selection", "peripheral B-lymphocyte negative selection", "peripheral B-cell negative selection"], "types": ["T038"], "canonical_name": "peripheral B cell negative selection", "definition": "Any process leading to negative selection of B cells in the periphery. [GOC:jal]"}
{"concept_id": "C1817737", "aliases": [], "types": ["T040"], "canonical_name": "defense response to tumor cell", "definition": "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C1817738", "aliases": ["B-cell homeostatic proliferation", "B-lymphocyte homeostatic proliferation", "B lymphocyte homeostatic proliferation"], "types": ["T043"], "canonical_name": "B cell homeostatic proliferation", "definition": "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus. [GOC:jal]"}
{"concept_id": "C1817739", "aliases": ["B-1 B lymphocyte proliferation", "B-1 B-cell proliferation", "B-1 B-lymphocyte proliferation"], "types": ["T043"], "canonical_name": "B-1 B cell proliferation", "definition": "The expansion of a B-1 B cell by cell division. Follows B cell activation. [GOC:jal]"}
{"concept_id": "C1817740", "aliases": ["T-cell lineage commitment", "T-lymphocyte lineage commitment", "T lymphocyte lineage commitment"], "types": ["T043"], "canonical_name": "T cell lineage commitment", "definition": "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817741", "aliases": ["CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation", "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation", "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation"], "types": ["T043"], "canonical_name": "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell. [GOC:add, PMID:15207821]"}
{"concept_id": "C1817742", "aliases": ["CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment", "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment", "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment"], "types": ["T043"], "canonical_name": "CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment", "definition": "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell. [GOC:add, PMID:15207821]"}
{"concept_id": "C1817743", "aliases": ["alpha-beta T-lymphocyte lineage commitment", "alpha-beta T lymphocyte lineage commitment", "alpha-beta T-cell lineage commitment"], "types": ["T043"], "canonical_name": "alpha-beta T cell lineage commitment", "definition": "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817744", "aliases": ["NK T lymphocyte lineage commitment", "natural killer T-cell lineage commitment", "natural killer T lymphocyte lineage commitment", "natural killer T-lymphocyte lineage commitment", "NK T-lymphocyte lineage commitment", "NK T-cell lineage commitment"], "types": ["T043"], "canonical_name": "NK T cell lineage commitment", "definition": "The process in which a pro-T cell becomes committed to becoming an NK T cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817745", "aliases": ["gamma-delta T-cell lineage commitment", "gamma-delta T-lymphocyte lineage commitment", "gamma-delta T lymphocyte lineage commitment"], "types": ["T043"], "canonical_name": "gamma-delta T cell lineage commitment", "definition": "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817746", "aliases": ["leukocyte activation during immune response", "leucocyte activation during immune response"], "types": ["T043"], "canonical_name": "immune cell activation during immune response"}
{"concept_id": "C1817747", "aliases": [], "types": ["T043"], "canonical_name": "cytokine production during immune response"}
{"concept_id": "C1817748", "aliases": ["B lymphocyte cytokine production", "B-cell cytokine production", "B-lymphocyte cytokine production"], "types": ["T043"], "canonical_name": "B cell cytokine production", "definition": "Any process that contributes to cytokine production by a B cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817749", "aliases": ["T lymphocyte cytokine production", "T-lymphocyte cytokine production", "T-cell cytokine production"], "types": ["T040"], "canonical_name": "T cell cytokine production", "definition": "Any process that contributes to cytokine production by a T cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817750", "aliases": ["NK cell cytokine production"], "types": ["T046"], "canonical_name": "natural killer cell cytokine production", "definition": "Any process that contributes to cytokine production by a natural killer cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817751", "aliases": [], "types": ["T040"], "canonical_name": "dendritic cell cytokine production", "definition": "Any process that contributes to cytokine production by a dendritic cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817752", "aliases": [], "types": ["T040"], "canonical_name": "myeloid dendritic cell cytokine production", "definition": "Any process that contributes to cytokine production by a myeloid dendritic cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817753", "aliases": [], "types": ["T040"], "canonical_name": "plasmacytoid dendritic cell cytokine production", "definition": "Any process that contributes to cytokine production by a plasmacytoid dendritic cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817756", "aliases": [], "types": ["T042"], "definition": "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. [GO_REF:0000022, GOC:add]", "canonical_name": "immune system process"}
{"concept_id": "C1817759", "aliases": ["immunoglobulin production during immune response"], "types": ["T043"], "canonical_name": "antibody production during immune response"}
{"concept_id": "C1817760", "aliases": ["regulation of glandular kallikrein-kinin cascade"], "types": ["T038"], "canonical_name": "regulation of tissue kallikrein-kinin cascade", "definition": "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade. [GOC:add]"}
{"concept_id": "C1817761", "aliases": [], "types": ["T040"], "canonical_name": "immune response in brain or nervous system", "definition": "An immune response taking place in the brain or nervous system. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817762", "aliases": [], "types": ["T040"], "canonical_name": "hepatic immune response", "definition": "An immune response taking place in the liver. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817764", "aliases": ["immune response in GALT"], "types": ["T042"], "canonical_name": "immune response in gut-associated lymphoid tissue", "definition": "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817765", "aliases": [], "types": ["T042"], "canonical_name": "immune response in Peyer's patch", "definition": "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817766", "aliases": [], "types": ["T042"], "canonical_name": "tolerance induction in Peyer's patch", "definition": "Tolerance induction taking place in the Peyer's patches. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817771", "aliases": ["tolerance induction in GALT"], "types": ["T042"], "canonical_name": "tolerance induction in gut-associated lymphoid tissue", "definition": "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT). [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817772", "aliases": ["immune response in NALT"], "types": ["T042"], "canonical_name": "immune response in nasopharyngeal-associated lymphoid tissue", "definition": "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817773", "aliases": [], "types": ["T044"], "canonical_name": "MHC protein complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]"}
{"concept_id": "C1817774", "aliases": [], "types": ["T044"], "canonical_name": "MHC class I protein complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817775", "aliases": [], "types": ["T044"], "canonical_name": "MHC class Ib protein complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules. [GOC:add, PMID:15928678, PMID:15928680]"}
{"concept_id": "C1817776", "aliases": ["ATPase-coupled monosaccharide transmembrane transporter activity", "monosaccharide-transporting ATPase activity", "ATP-dependent monosaccharide transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type monosaccharide transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported. [EC:7.5.2.-]"}
{"concept_id": "C1817777", "aliases": [], "types": ["T044"], "canonical_name": "polyamine-importing ATPase activity"}
{"concept_id": "C1817778", "aliases": [], "types": ["T044"], "canonical_name": "hexuronate (glucuronate/galacturonate) porter activity"}
{"concept_id": "C1817779", "aliases": [], "types": ["T044"], "canonical_name": "putrescine porter activity"}
{"concept_id": "C1817781", "aliases": [], "types": ["T044"], "canonical_name": "glutamine porter activity"}
{"concept_id": "C1817783", "aliases": [], "types": ["T044"], "canonical_name": "glycerol-phosphate porter activity"}
{"concept_id": "C1817784", "aliases": [], "types": ["T044"], "canonical_name": "D-allose porter activity"}
{"concept_id": "C1817787", "aliases": [], "types": ["T044"], "canonical_name": "lactate permease"}
{"concept_id": "C1817789", "aliases": [], "types": ["T043"], "canonical_name": "aspartate transport"}
{"concept_id": "C1817791", "aliases": [], "types": ["T043"], "canonical_name": "histidine transport", "definition": "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817792", "aliases": [], "types": ["T043"], "canonical_name": "isoleucine transport", "definition": "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817793", "aliases": [], "types": ["T044"], "canonical_name": "lysine transport", "definition": "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817794", "aliases": [], "types": ["T043"], "canonical_name": "leucine transport", "definition": "The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817795", "aliases": [], "types": ["T043"], "canonical_name": "methionine transport", "definition": "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817796", "aliases": [], "types": ["T043"], "canonical_name": "ornithine transport", "definition": "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817797", "aliases": [], "types": ["T043"], "canonical_name": "phenylalanine transport", "definition": "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817798", "aliases": [], "types": ["T043"], "canonical_name": "proline transport", "definition": "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817799", "aliases": [], "types": ["T043"], "canonical_name": "threonine transport", "definition": "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817800", "aliases": [], "types": ["T043"], "canonical_name": "tryptophan transport", "definition": "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817801", "aliases": [], "types": ["T043"], "canonical_name": "tyrosine transport", "definition": "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817802", "aliases": [], "types": ["T043"], "canonical_name": "valine transport", "definition": "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C1817803", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan recognition activity"}
{"concept_id": "C1817804", "aliases": ["metabolic process resulting in cell growth"], "types": ["T044"], "canonical_name": "metabolic process resulting in cell growth", "definition": "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell. [GOC:dph]"}
{"concept_id": "C1817805", "aliases": ["monoterpene metabolism"], "types": ["T044"], "canonical_name": "monoterpene metabolic process", "definition": "The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure. [Wikipedia:Monoterpene]"}
{"concept_id": "C1817806", "aliases": ["monoterpene biosynthesis"], "types": ["T044"], "canonical_name": "monoterpene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure. [Wikipedia:Monoterpene]"}
{"concept_id": "C1817807", "aliases": ["monoterpene catabolism"], "types": ["T044"], "canonical_name": "monoterpene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure. [PMID:25076942]"}
{"concept_id": "C1817808", "aliases": [], "types": ["T044"], "canonical_name": "diterpene metabolic process"}
{"concept_id": "C1817809", "aliases": [], "types": ["T044"], "canonical_name": "diterpene biosynthetic process"}
{"concept_id": "C1817810", "aliases": [], "types": ["T044"], "canonical_name": "diterpene catabolic process"}
{"concept_id": "C1817811", "aliases": [], "types": ["T044"], "canonical_name": "triterpene biosynthetic process"}
{"concept_id": "C1817812", "aliases": [], "types": ["T044"], "canonical_name": "triterpene catabolic process"}
{"concept_id": "C1817813", "aliases": [], "types": ["T044"], "canonical_name": "sesquiterpene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. [GOC:ai]"}
{"concept_id": "C1817814", "aliases": [], "types": ["T044"], "canonical_name": "tetraterpene metabolic process"}
{"concept_id": "C1817815", "aliases": [], "types": ["T044"], "canonical_name": "tetraterpene biosynthetic process"}
{"concept_id": "C1817816", "aliases": [], "types": ["T044"], "canonical_name": "tetraterpene catabolic process"}
{"concept_id": "C1817820", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome B-245"}
{"concept_id": "C1817821", "aliases": [], "types": ["T044"], "canonical_name": "Core 1 GalT"}
{"concept_id": "C1817822", "aliases": [], "types": ["T042"], "canonical_name": "dendrite development", "definition": "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]"}
{"concept_id": "C1817823", "aliases": ["somatic diversification of antibodies"], "types": ["T038"], "canonical_name": "somatic diversification of immunoglobulins", "definition": "The somatic process that results in the generation of sequence diversity of immunoglobulins. [GOC:add, GOC:ma, ISBN:0781735149]"}
{"concept_id": "C1817824", "aliases": ["somatic recombination of antibody gene segments"], "types": ["T045"], "canonical_name": "somatic recombination of immunoglobulin gene segments", "definition": "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817825", "aliases": ["myosin complex location"], "types": ["T026"], "canonical_name": "myosin complex", "definition": "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. [GOC:mah, Wikipedia:Myosin]"}
{"concept_id": "C1817826", "aliases": ["myosin II complex location"], "types": ["T026"], "canonical_name": "myosin II complex", "definition": "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. [Wikipedia:Myosin]"}
{"concept_id": "C1817827", "aliases": ["unconventional myosin complex location"], "types": ["T026"], "canonical_name": "unconventional myosin complex", "definition": "A portmanteau term for myosins other than myosin II. [GOC:ma]"}
{"concept_id": "C1817828", "aliases": [], "types": ["T044"], "canonical_name": "latrophilin"}
{"concept_id": "C1817830", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor"}
{"concept_id": "C1817831", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen"}
{"concept_id": "C1817832", "aliases": [], "types": ["T044"], "canonical_name": "glycosylase"}
{"concept_id": "C1817833", "aliases": [], "types": ["T044"], "canonical_name": "N-glycosylase"}
{"concept_id": "C1817834", "aliases": ["aldolase activity"], "types": ["T044"], "canonical_name": "aldolase activity"}
{"concept_id": "C1817835", "aliases": [], "types": ["T044"], "canonical_name": "ligand-dependent nuclear receptor interactor activity"}
{"concept_id": "C1817836", "aliases": [], "types": ["T044"], "canonical_name": "nickel superoxide oxidoreductase"}
{"concept_id": "C1817839", "aliases": ["potassium:amino acid symporter activity"], "types": ["T044"], "canonical_name": "amino acid:potassium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in). [GOC:ai]"}
{"concept_id": "C1817841", "aliases": [], "types": ["T044"], "canonical_name": "benzyl alcohol dehydrogenase activity"}
{"concept_id": "C1817842", "aliases": [], "types": ["T044"], "canonical_name": "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase"}
{"concept_id": "C1817843", "aliases": ["methionine and threonine metabolic process"], "types": ["T044"], "canonical_name": "methionine and threonine metabolic process", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]"}
{"concept_id": "C1817845", "aliases": [], "types": ["T044"], "canonical_name": "glutaredoxin reductase"}
{"concept_id": "C1817846", "aliases": [], "types": ["T044"], "canonical_name": "MHC class II protein complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817847", "aliases": ["tolerance induction in NALT"], "types": ["T042"], "canonical_name": "tolerance induction in nasopharyngeal-associated lymphoid tissue", "definition": "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT). [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817848", "aliases": [], "types": ["T042"], "canonical_name": "nasal tolerance"}
{"concept_id": "C1817849", "aliases": ["tolerance induction in MALT"], "types": ["T042"], "canonical_name": "tolerance induction in mucosal-associated lymphoid tissue", "definition": "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT). [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817850", "aliases": ["B cell tolerance induction in MALT"], "types": ["T043"], "canonical_name": "B cell tolerance induction in mucosal-associated lymphoid tissue", "definition": "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817851", "aliases": ["T cell tolerance induction in MALT"], "types": ["T042"], "canonical_name": "T cell tolerance induction in mucosal-associated lymphoid tissue", "definition": "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells. [GOC:jal, ISBN:0781735149, PMID:16551263]"}
{"concept_id": "C1817852", "aliases": ["antigen sampling in MALT"], "types": ["T038"], "canonical_name": "antigen sampling in mucosal-associated lymphoid tissue", "definition": "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue. [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746]"}
{"concept_id": "C1817853", "aliases": [], "types": ["T038"], "canonical_name": "antigen transport in MALT"}
{"concept_id": "C1817854", "aliases": [], "types": ["T038"], "canonical_name": "antigen transport in mucosal-associated lymphoid tissue"}
{"concept_id": "C1817855", "aliases": ["antigen sampling by dendritic cells in MALT"], "types": ["T038"], "canonical_name": "antigen sampling by dendritic cells in mucosal-associated lymphoid tissue", "definition": "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue. [GOC:jal, PMID:11896763, PMID:15681746]"}
{"concept_id": "C1817856", "aliases": ["antigen sampling by M cells in MALT"], "types": ["T038"], "canonical_name": "antigen sampling by M cells in mucosal-associated lymphoid tissue", "definition": "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue. [GOC:jal, PMID:11896763]"}
{"concept_id": "C1817857", "aliases": [], "types": ["T043"], "canonical_name": "dendritic cell chemotaxis", "definition": "The movement of a dendritic cell in response to an external stimulus. [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]"}
{"concept_id": "C1817858", "aliases": [], "types": ["T043"], "canonical_name": "myeloid dendritic cell chemotaxis", "definition": "The movement of a myeloid dendritic cell in response to an external stimulus. [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]"}
{"concept_id": "C1817859", "aliases": [], "types": ["T043"], "canonical_name": "Langerhans cell chemotaxis", "definition": "The movement of a Langerhans cell in response to an external stimulus. [GOC:add, PMID:16056255, PMID:16387601]"}
{"concept_id": "C1817860", "aliases": [], "types": ["T043"], "canonical_name": "plasmacytoid dendritic cell chemotaxis", "definition": "The movement of a plasmacytoid dendritic cell in response to an external stimulus. [GOC:add, PMID:15159375, PMID:15814331]"}
{"concept_id": "C1817861", "aliases": [], "types": ["T040"], "canonical_name": "T cell tolerance induction to tumor cell", "definition": "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C1817862", "aliases": ["antigen transport by M cells in mucosal-associated lymphoid tissue", "antigen transport by M cells in MALT", "antigen transcytosis by M cells in MALT"], "types": ["T043"], "canonical_name": "antigen transcytosis by M cells in mucosal-associated lymphoid tissue", "definition": "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT. [GOC:jal, ISBN:0781735149, PMID:12843411]"}
{"concept_id": "C1817863", "aliases": [], "types": ["T040"], "canonical_name": "tolerance induction to tumor cell", "definition": "A process of tolerance induction which leads to immunological tolerance of a tumor. [GOC:add]"}
{"concept_id": "C1817864", "aliases": [], "types": ["T043"], "canonical_name": "immunoglobulin transcytosis in epithelial cells", "definition": "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other. [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]"}
{"concept_id": "C1817865", "aliases": ["immunoglobulin transcytosis mediated by pIgR", "antibody transcytosis mediated by pIgR"], "types": ["T043"], "canonical_name": "immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor", "definition": "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa. [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]"}
{"concept_id": "C1817866", "aliases": ["IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor", "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor"], "types": ["T043"], "canonical_name": "IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor", "definition": "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals. [GOC:add, ISBN:0781735149, ISBN:081533642X]"}
{"concept_id": "C1817867", "aliases": ["B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen", "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen", "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen"], "types": ["T043"], "canonical_name": "B cell antigen processing and presentation mediated by B cell receptor uptake of antigen", "definition": "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817868", "aliases": [], "types": ["T040"], "canonical_name": "immune response to tumor cell", "definition": "An immune system process that functions in the response of an organism to a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C1817869", "aliases": ["T-lymphocyte mediated cytotoxicity directed against tumor cell target", "T-cell mediated cytotoxicity directed against tumor cell target", "T lymphocyte mediated cytotoxicity directed against tumor cell target"], "types": ["T043"], "canonical_name": "T cell mediated cytotoxicity directed against tumor cell target", "definition": "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C1817870", "aliases": ["NK cell mediated cytotoxicity directed against tumor cell target"], "types": ["T043"], "canonical_name": "natural killer cell mediated cytotoxicity directed against tumor cell target", "definition": "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C1817871", "aliases": ["B lymphocyte antigen processing and presentation following pinocytosis", "B-cell antigen processing and presentation following pinocytosis", "B-lymphocyte antigen processing and presentation following pinocytosis"], "types": ["T043"], "canonical_name": "B cell antigen processing and presentation following pinocytosis", "definition": "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis. [GOC:add, PMID:7543530]"}
{"concept_id": "C1817873", "aliases": [], "types": ["T046"], "canonical_name": "natural killer cell mediated immune response to tumor cell", "definition": "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C1817874", "aliases": [], "types": ["T040"], "canonical_name": "T cell mediated immune response to tumor cell", "definition": "An immune response mediated by a T cell triggered in response to the presence of a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C1817875", "aliases": [], "types": ["T042"], "canonical_name": "tolerance induction in urogenital tract", "definition": "Tolerance induction taking place in the urogenital tract. [GOC:jal]"}
{"concept_id": "C1817876", "aliases": ["antibody production in mucosal tissue"], "types": ["T038"], "canonical_name": "immunoglobulin production in mucosal tissue", "definition": "The synthesis and release of immunoglobulin in the mucosal tissue. [GOC:jal]"}
{"concept_id": "C1817877", "aliases": [], "types": ["T042"], "canonical_name": "mucosal tolerance induction", "definition": "Tolerance induction taking place in the mucosal tissues. [GOC:jal]"}
{"concept_id": "C1817878", "aliases": ["peptide antigen processing and presentation via MHC class Ib"], "types": ["T043"], "canonical_name": "antigen processing and presentation of peptide antigen via MHC class Ib", "definition": "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family. [GOC:add, PMID:15928678]"}
{"concept_id": "C1817879", "aliases": ["immune response-activating cell surface receptor signalling pathway", "activation of immune response by cell surface receptor signaling pathway"], "types": ["T044"], "canonical_name": "immune response-activating cell surface receptor signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a cell capable of activating or perpetuating an immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817880", "aliases": ["complement receptor mediated signalling pathway"], "types": ["T044"], "canonical_name": "complement receptor mediated signaling pathway", "definition": "The series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817881", "aliases": ["Fc receptor mediated stimulatory signalling pathway", "Fc-receptor mediated stimulatory signaling pathway"], "types": ["T044"], "canonical_name": "Fc receptor mediated stimulatory signaling pathway", "definition": "The series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817882", "aliases": [], "types": ["T038"], "definition": "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic. [GO_REF:0000022, GOC:add, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X]", "canonical_name": "granuloma formation"}
{"concept_id": "C1817884", "aliases": [], "types": ["T038"], "canonical_name": "immune complex clearance", "definition": "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. [GO_REF:0000022, GOC:add, ISBN:068340007X]"}
{"concept_id": "C1817885", "aliases": ["immune complex clearance by red blood cells", "immune complex clearance by RBCs"], "types": ["T038"], "canonical_name": "immune complex clearance by erythrocytes", "definition": "The process of immune complex clearance by erythrocytes. The process often starts with binding of complement receptor 1 (CR1) on the surface of erythrocytes to a complement coated immune complex. The complex bound to erythrocyte CR1 is then transported to the liver or spleen where it is presented to phagocytes. The process ends when the complex is removed from CR1, allowing the erythrocyte to return to general circulation. [GOC:add, PMID:11414352, PMID:24022490]"}
{"concept_id": "C1817886", "aliases": [], "types": ["T038"], "canonical_name": "immune complex clearance by monocytes and macrophages", "definition": "The process of immune complex clearance by monocytes or macrophages. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817887", "aliases": [], "types": ["T046"], "canonical_name": "inflammatory response to antigenic stimulus", "definition": "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817888", "aliases": [], "types": ["T046"], "canonical_name": "acute inflammatory response to antigenic stimulus", "definition": "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817889", "aliases": [], "types": ["T046"], "canonical_name": "chronic inflammatory response to antigenic stimulus", "definition": "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817890", "aliases": [], "types": ["T038"], "canonical_name": "production of molecular mediator of immune response", "definition": "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817891", "aliases": [], "types": ["T038"], "canonical_name": "production of cellular mediator of immune response"}
{"concept_id": "C1817894", "aliases": ["leukocyte immune effector process", "immune cell mediated immunity", "leucocyte mediated immunity", "immune cell effector process", "leucocyte immune effector process"], "types": ["T038"], "canonical_name": "leukocyte mediated immunity", "definition": "Any process involved in the carrying out of an immune response by a leukocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817895", "aliases": ["myeloid leukocyte immune effector process", "myeloid leucocyte immune effector process", "myeloid leucocyte mediated immunity"], "types": ["T038"], "canonical_name": "myeloid leukocyte mediated immunity", "definition": "Any process involved in the carrying out of an immune response by a myeloid leukocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817896", "aliases": [], "types": ["T038"], "canonical_name": "neutrophil mediated immunity", "definition": "Any process involved in the carrying out of an immune response by a neutrophil. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817897", "aliases": [], "types": ["T038"], "canonical_name": "eosinophil mediated immunity", "definition": "Any process involved in the carrying out of an immune response by an eosinophil. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817898", "aliases": [], "types": ["T038"], "canonical_name": "mast cell mediated immunity", "definition": "Any process involved in the carrying out of an immune response by a mast cell. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817899", "aliases": [], "types": ["T038"], "canonical_name": "lymphocyte mediated immunity", "definition": "Any process involved in the carrying out of an immune response by a lymphocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817900", "aliases": ["B-cell antigen processing and presentation", "B-lymphocyte antigen processing and presentation", "B lymphocyte antigen processing and presentation"], "types": ["T043"], "canonical_name": "B cell antigen processing and presentation", "definition": "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817901", "aliases": ["peripheral B lymphocyte tolerance induction", "peripheral B-cell tolerance induction", "peripheral B-lymphocyte tolerance induction"], "types": ["T043"], "canonical_name": "peripheral B cell tolerance induction", "definition": "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817902", "aliases": ["B-lymphocyte receptor editing", "B-cell receptor editing", "B lymphocyte receptor editing"], "types": ["T045"], "canonical_name": "B cell receptor editing", "definition": "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817903", "aliases": ["peripheral B lymphocyte anergy", "peripheral B-cell anergy", "peripheral B-lymphocyte anergy"], "types": ["T038"], "canonical_name": "peripheral B cell anergy", "definition": "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817904", "aliases": ["peripheral B lymphocyte deletion", "peripheral B-cell deletion", "peripheral B-lymphocyte deletion"], "types": ["T043"], "canonical_name": "peripheral B cell deletion", "definition": "The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection. [GOC:add, GOC:jal, GOC:mtg_apoptosis, ISBN:0781735149]"}
{"concept_id": "C1817905", "aliases": ["circulating immunoglobulin mediated immune response", "circulating antibody mediated immune response", "humoral immune response mediated by circulating antibody"], "types": ["T043"], "canonical_name": "humoral immune response mediated by circulating immunoglobulin", "definition": "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817907", "aliases": ["T-lymphocyte mediated immunity", "T-cell mediated immunity", "T lymphocyte mediated immunity"], "types": ["T040"], "canonical_name": "T cell mediated immunity", "definition": "Any process involved in the carrying out of an immune response by a T cell. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817908", "aliases": [], "types": ["T043"], "canonical_name": "cellular immune response"}
{"concept_id": "C1817909", "aliases": ["T-cell antigen processing and presentation", "T lymphocyte antigen processing and presentation", "T-lymphocyte antigen processing and presentation"], "types": ["T043"], "canonical_name": "T cell antigen processing and presentation", "definition": "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, PMID:11417857, PMID:15120183]"}
{"concept_id": "C1817910", "aliases": ["peripheral T-lymphocyte tolerance induction", "peripheral T-cell tolerance induction", "peripheral T lymphocyte tolerance induction"], "types": ["T040"], "canonical_name": "peripheral T cell tolerance induction", "definition": "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817912", "aliases": [], "types": ["T040"], "canonical_name": "adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "definition": "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831]"}
{"concept_id": "C1817913", "aliases": ["immune response-dependent tolerance induction"], "types": ["T040"], "canonical_name": "tolerance induction dependent upon immune response", "definition": "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817914", "aliases": [], "types": ["T040"], "canonical_name": "tolerance induction to nonself antigen", "definition": "Tolerance induction in response to nonself antigens. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817915", "aliases": [], "types": ["T040"], "canonical_name": "central tolerance induction to nonself antigen", "definition": "Tolerance induction to nonself antigens in the central lymphoid organs. [GOC:jal, PMID:12547504]"}
{"concept_id": "C1817916", "aliases": [], "types": ["T040"], "canonical_name": "peripheral tolerance induction to nonself antigen", "definition": "Tolerance induction to nonself antigens in the periphery. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817917", "aliases": [], "types": ["T040"], "canonical_name": "peripheral tolerance induction", "definition": "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817918", "aliases": [], "types": ["T040"], "canonical_name": "peripheral tolerance induction to self antigen", "definition": "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817919", "aliases": [], "types": ["T040"], "canonical_name": "germinal center formation", "definition": "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation. [GO_REF:0000022, GOC:jal, ISBN:081533642X]"}
{"concept_id": "C1817920", "aliases": [], "types": ["T043"], "canonical_name": "dendritic cell antigen processing and presentation", "definition": "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817921", "aliases": [], "types": ["T043"], "canonical_name": "myeloid dendritic cell antigen processing and presentation", "definition": "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817922", "aliases": [], "types": ["T043"], "canonical_name": "plasmacytoid dendritic cell antigen processing and presentation", "definition": "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817923", "aliases": [], "types": ["T043"], "canonical_name": "monocyte antigen processing and presentation", "definition": "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, PMID:11200054]"}
{"concept_id": "C1817924", "aliases": [], "types": ["T043"], "canonical_name": "macrophage antigen processing and presentation", "definition": "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817925", "aliases": [], "types": ["T043"], "canonical_name": "non-professional antigen presenting cell antigen processing and presentation", "definition": "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817926", "aliases": ["peptide antigen processing and presentation via MHC class I"], "types": ["T043"], "canonical_name": "antigen processing and presentation of peptide antigen via MHC class I", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]"}
{"concept_id": "C1817927", "aliases": [], "types": ["T043"], "canonical_name": "antigen processing and presentation via MHC class Ib", "definition": "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. [GOC:add, PMID:15928678, PMID:15928680]"}
{"concept_id": "C1817928", "aliases": ["endogenous peptide antigen processing and presentation via MHC class Ib"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class Ib", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. [GOC:add, PMID:15928678]"}
{"concept_id": "C1817929", "aliases": ["exogenous peptide antigen processing and presentation via MHC class Ib"], "types": ["T043"], "canonical_name": "antigen processing and presentation of exogenous peptide antigen via MHC class Ib", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. [GOC:add, PMID:15928678]"}
{"concept_id": "C1817930", "aliases": ["exogenous peptide antigen processing and presentation"], "types": ["T043"], "canonical_name": "antigen processing and presentation of exogenous peptide antigen", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817931", "aliases": ["TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I", "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I", "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent"], "types": ["T043"], "canonical_name": "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules. [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]"}
{"concept_id": "C1817932", "aliases": ["TAP-independent exogenous peptide antigen processing and presentation via MHC class I", "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I", "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent"], "types": ["T043"], "canonical_name": "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules. [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]"}
{"concept_id": "C1817933", "aliases": ["TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib", "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent", "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib"], "types": ["T043"], "canonical_name": "antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. [GOC:add, PMID:15928678]"}
{"concept_id": "C1817934", "aliases": ["TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib", "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib", "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent"], "types": ["T043"], "canonical_name": "antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. [GOC:add, PMID:15928678]"}
{"concept_id": "C1817935", "aliases": ["endogenous peptide antigen processing and presentation"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817936", "aliases": ["endogenous peptide antigen processing and presentation via MHC class I via ER pathway"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]"}
{"concept_id": "C1817937", "aliases": ["TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway", "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway", "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]"}
{"concept_id": "C1817938", "aliases": ["TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway", "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway", "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules. [GOC:add, PMID:14647477, PMID:15771591]"}
{"concept_id": "C1817939", "aliases": ["endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules. [GOC:add, PMID:10631943]"}
{"concept_id": "C1817940", "aliases": ["endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. [GOC:add, PMID:15928678]"}
{"concept_id": "C1817941", "aliases": ["endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent", "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway", "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. [GOC:add, PMID:15928678]"}
{"concept_id": "C1817942", "aliases": ["TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway", "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent", "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. [GOC:add, PMID:15928678]"}
{"concept_id": "C1817943", "aliases": ["endogenous peptide antigen processing and presentation via MHC class II"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class II", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. [GOC:add, PMID:15531770, PMID:16181338]"}
{"concept_id": "C1817944", "aliases": [], "types": ["T044"], "canonical_name": "peptide antigen assembly with MHC class Ib protein complex", "definition": "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. [GOC:add, PMID:15928678]"}
{"concept_id": "C1817945", "aliases": [], "types": ["T044"], "canonical_name": "lipid antigen assembly with MHC class Ib protein complex", "definition": "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family. [GOC:add, PMID:15928678, PMID:15928680]"}
{"concept_id": "C1817946", "aliases": [], "types": ["T043"], "canonical_name": "lipid antigen transport", "definition": "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:add, PMID:15928678, PMID:15928680]"}
{"concept_id": "C1817947", "aliases": ["peptide antigen processing and presentation via MHC class II"], "types": ["T043"], "canonical_name": "antigen processing and presentation of peptide antigen via MHC class II", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591]"}
{"concept_id": "C1817948", "aliases": [], "types": ["T044"], "canonical_name": "proteolysis associated with antigen processing and presentation", "definition": "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation. [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]"}
{"concept_id": "C1817950", "aliases": ["ER proteolysis associated with antigen processing and presentation", "proteolysis within ER associated with antigen processing and presentation", "endoplasmic reticulum proteolysis associated with antigen processing and presentation"], "types": ["T044"], "canonical_name": "proteolysis within endoplasmic reticulum associated with antigen processing and presentation", "definition": "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation. [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]"}
{"concept_id": "C1817951", "aliases": ["endosomal proteolysis associated with antigen processing and presentation"], "types": ["T044"], "canonical_name": "proteolysis within endosome associated with antigen processing and presentation", "definition": "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817952", "aliases": ["lysosomal proteolysis associated with antigen processing and presentation"], "types": ["T044"], "canonical_name": "proteolysis within lysosome associated with antigen processing and presentation", "definition": "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817953", "aliases": [], "types": ["T044"], "canonical_name": "peptide antigen assembly with MHC protein complex", "definition": "The binding of a peptide to the antigen binding groove of an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817954", "aliases": [], "types": ["T044"], "canonical_name": "peptide antigen assembly with MHC class I protein complex", "definition": "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817955", "aliases": [], "types": ["T044"], "canonical_name": "peptide antigen assembly with MHC class II protein complex", "definition": "The binding of a peptide to the antigen binding groove of an MHC class II protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1817956", "aliases": ["peptide or polysaccharide antigen processing and presentation of via MHC class II"], "types": ["T043"], "canonical_name": "antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "definition": "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240]"}
{"concept_id": "C1817957", "aliases": ["polysaccharide antigen processing and presentation via MHC class II"], "types": ["T043"], "canonical_name": "antigen processing and presentation of polysaccharide antigen via MHC class II", "definition": "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex. [GOC:add, PMID:16153240]"}
{"concept_id": "C1817958", "aliases": [], "types": ["T044"], "canonical_name": "polysaccharide assembly with MHC class II protein complex"}
{"concept_id": "C1817959", "aliases": [], "types": ["T038"], "canonical_name": "tolerance induction", "definition": "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817960", "aliases": [], "types": ["T038"], "canonical_name": "central tolerance induction", "definition": "Tolerance induction in the central lymphoid organs: the thymus and bone marrow. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817961", "aliases": [], "types": ["T038"], "canonical_name": "central tolerance induction to self antigen", "definition": "Tolerance induction in the central lymphoid organs directed at self antigens. [GOC:jal, ISBN:0781735149, PMID:16460922]"}
{"concept_id": "C1817962", "aliases": ["central B lymphocyte tolerance induction", "central B-cell tolerance induction", "central B-lymphocyte tolerance induction"], "types": ["T038"], "canonical_name": "central B cell tolerance induction", "definition": "Tolerance induction of B cells in the bone marrow. [GOC:jal, PMID:16460922]"}
{"concept_id": "C1817963", "aliases": ["central B-lymphocyte receptor editing", "central B-cell receptor editing", "central B lymphocyte receptor editing"], "types": ["T045"], "canonical_name": "central B cell receptor editing", "definition": "Receptor editing occurring in B cells in the bone marrow. [GOC:jal, PMID:16460922]"}
{"concept_id": "C1817964", "aliases": ["central T lymphocyte tolerance induction", "central T-lymphocyte tolerance induction", "central T-cell tolerance induction"], "types": ["T038"], "canonical_name": "central T cell tolerance induction", "definition": "Tolerance induction of T cells in the thymus. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817965", "aliases": [], "types": ["T038"], "canonical_name": "tolerance induction to self antigen", "definition": "Tolerance induction directed at self antigens. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817966", "aliases": ["B-lymphocyte tolerance induction", "B lymphocyte tolerance induction", "B-cell tolerance induction"], "types": ["T038"], "canonical_name": "B cell tolerance induction", "definition": "A process involving any mechanism for tolerance induction in B cells. [GOC:jal, ISBN:0781735149, PMID:16460922]"}
{"concept_id": "C1817967", "aliases": ["B-cell anergy", "B lymphocyte anergy", "B-lymphocyte anergy"], "types": ["T038"], "canonical_name": "B cell anergy", "definition": "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817968", "aliases": ["B lymphocyte deletion", "B-cell deletion", "B-lymphocyte deletion"], "types": ["T043"], "canonical_name": "B cell deletion", "definition": "The apoptotic death of B cells which is part of B cell tolerance induction. [GOC:add, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817969", "aliases": ["T-cell tolerance induction", "T-lymphocyte tolerance induction", "T lymphocyte tolerance induction"], "types": ["T038"], "canonical_name": "T cell tolerance induction", "definition": "A process involving any mechanism for tolerance induction in T cells. [GOC:jal, ISBN:0781735149, PMID:16551263]"}
{"concept_id": "C1817970", "aliases": [], "types": ["T043"], "canonical_name": "lymphocyte chemotaxis across high endothelial venule", "definition": "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus. [GOC:add, ISBN:0781735149, PMID:15122201]"}
{"concept_id": "C1817971", "aliases": ["NK cell tolerance induction"], "types": ["T038"], "canonical_name": "natural killer cell tolerance induction", "definition": "Tolerance induction of natural killer cells. [GOC:jal, PMID:16546094]"}
{"concept_id": "C1817972", "aliases": [], "types": ["T038"], "canonical_name": "immune system development", "definition": "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. [GOC:add, GOC:dph]"}
{"concept_id": "C1817973", "aliases": ["immune cell differentiation", "leukocyte differentiation"], "types": ["T043"], "definition": "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. [CL:0000738, GOC:add, PMID:16551264]", "canonical_name": "leucocyte differentiation"}
{"concept_id": "C1817974", "aliases": ["leucocyte trafficking during immune response", "immune cell trafficking during immune response", "immune cell migration during immune response", "leucocyte migration during immune response", "leukocyte trafficking during immune response"], "types": ["T043"], "canonical_name": "leukocyte migration involved in immune response", "definition": "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]"}
{"concept_id": "C1817975", "aliases": ["leukocyte migration during inflammatory response", "leucocyte migration during inflammatory response", "immune cell trafficking during inflammatory response", "leukocyte trafficking during inflammatory response", "leucocyte trafficking during inflammatory response"], "types": ["T043"], "canonical_name": "immune cell migration during inflammatory response"}
{"concept_id": "C1817976", "aliases": [], "types": ["T046"], "canonical_name": "hypersensitivity response"}
{"concept_id": "C1817977", "aliases": [], "types": ["T046"], "canonical_name": "acute inflammatory response to non-antigenic stimulus", "definition": "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma. [GOC:jal, PMID:16459497, PMID:9073326]"}
{"concept_id": "C1817978", "aliases": [], "types": ["T046"], "canonical_name": "acute inflammatory response", "definition": "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C1817979", "aliases": [], "types": ["T039"], "canonical_name": "vasodilation during acute inflammatory response"}
{"concept_id": "C1817980", "aliases": [], "types": ["T039"], "canonical_name": "regulation of vascular permeability during acute inflammatory response"}
{"concept_id": "C1817981", "aliases": [], "types": ["T038"], "canonical_name": "regulation of plasma kallikrein-kinin cascade", "definition": "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade. [GOC:add]"}
{"concept_id": "C1817982", "aliases": ["regulation of systemic arterial blood pressure during acute phase response"], "types": ["T039"], "canonical_name": "blood pressure regulation during acute phase response"}
{"concept_id": "C1817983", "aliases": [], "types": ["T039"], "canonical_name": "regulation of heart contraction during acute phase response"}
{"concept_id": "C1817985", "aliases": [], "types": ["T046"], "canonical_name": "production of cellular mediator of acute inflammation"}
{"concept_id": "C1817989", "aliases": ["production of reactive oxygen species during acute inflammatory response", "respiratory burst involved in acute inflammatory response"], "types": ["T039"], "canonical_name": "oxidative burst during acute inflammatory response"}
{"concept_id": "C1817995", "aliases": ["Hageman factor activation"], "types": ["T044"], "canonical_name": "Factor XII activation", "definition": "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade. [GOC:jal, ISBN:0721601871]"}
{"concept_id": "C1817996", "aliases": ["activation of clotting cascade"], "types": ["T040"], "canonical_name": "activation of blood coagulation via clotting cascade", "definition": "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817997", "aliases": [], "types": ["T046"], "canonical_name": "chronic inflammatory response", "definition": "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. [GO_REF:0000022, GOC:jal, ISBN:0781735149]"}
{"concept_id": "C1817998", "aliases": [], "types": ["T046"], "canonical_name": "chronic inflammatory response to non-antigenic stimulus", "definition": "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma. [GOC:jal]"}
{"concept_id": "C1817999", "aliases": ["down regulation of tissue kallikrein-kinin cascade", "negative regulation of glandular kallikrein-kinin cascade", "down-regulation of tissue kallikrein-kinin cascade", "downregulation of tissue kallikrein-kinin cascade"], "types": ["T039"], "canonical_name": "negative regulation of tissue kallikrein-kinin cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade. [GOC:add]"}
{"concept_id": "C1818000", "aliases": ["up-regulation of tissue kallikrein-kinin cascade", "positive regulation of glandular kallikrein-kinin cascade", "upregulation of tissue kallikrein-kinin cascade", "up regulation of tissue kallikrein-kinin cascade"], "types": ["T039"], "canonical_name": "positive regulation of tissue kallikrein-kinin cascade", "definition": "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade. [GOC:add]"}
{"concept_id": "C1818001", "aliases": ["down-regulation of plasma kallikrein-kinin cascade", "downregulation of plasma kallikrein-kinin cascade", "down regulation of plasma kallikrein-kinin cascade"], "types": ["T039"], "canonical_name": "negative regulation of plasma kallikrein-kinin cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade. [GOC:add]"}
{"concept_id": "C1818002", "aliases": ["up regulation of plasma kallikrein-kinin cascade", "upregulation of plasma kallikrein-kinin cascade", "up-regulation of plasma kallikrein-kinin cascade"], "types": ["T039"], "canonical_name": "positive regulation of plasma kallikrein-kinin cascade", "definition": "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade. [GOC:add]"}
{"concept_id": "C1818003", "aliases": [], "types": ["T043"], "canonical_name": "mast cell chemotaxis", "definition": "The movement of a mast cell in response to an external stimulus. [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392]"}
{"concept_id": "C1818004", "aliases": [], "types": ["T043"], "canonical_name": "serotonin secretion by mast cell", "definition": "The regulated release of serotonin by a mast cell or group of mast cells. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818005", "aliases": [], "types": ["T043"], "canonical_name": "histamine secretion by mast cell", "definition": "The regulated release of histamine by a mast cell or group of mast cells. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818006", "aliases": [], "types": ["T043"], "canonical_name": "serotonin secretion by platelet", "definition": "The regulated release of serotonin by a platelet or group of platelets. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818007", "aliases": [], "types": ["T043"], "canonical_name": "histamine secretion by platelet", "definition": "The regulated release of histamine by a platelet or group of platelets. [GOC:add, PMID:9117517]"}
{"concept_id": "C1818008", "aliases": [], "types": ["T043"], "canonical_name": "serotonin secretion by basophil", "definition": "The regulated release of serotonin by a basophil or group of basophils. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818009", "aliases": [], "types": ["T043"], "canonical_name": "histamine secretion by basophil", "definition": "The regulated release of histamine by a basophil or group of basophils. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818010", "aliases": [], "types": ["T044"], "canonical_name": "siderochrome biosynthetic process"}
{"concept_id": "C1818011", "aliases": [], "types": ["T044"], "canonical_name": "aromatic hydrocarbon biosynthetic process"}
{"concept_id": "C1818012", "aliases": [], "types": ["T044"], "canonical_name": "aromatic hydrocarbon catabolic process"}
{"concept_id": "C1818015", "aliases": [], "types": ["T044"], "canonical_name": "aerobic glycerol fermentation"}
{"concept_id": "C1818017", "aliases": ["small protein conjugating enzyme activity"], "types": ["T044"], "canonical_name": "small conjugating protein ligase activity"}
{"concept_id": "C1818018", "aliases": ["hemolysis by symbiont of host RBCs", "regulation of cytolysis of host cells by symbiont", "haemolysis in host", "hemolysis by symbiont of host red blood cells"], "types": ["T040"], "canonical_name": "hemolysis by symbiont of host erythrocytes", "definition": "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:add, UniProtKB-KW:KW-0354]"}
{"concept_id": "C1818019", "aliases": ["endogenous peptide antigen processing and presentation via MHC class I"], "types": ["T043"], "canonical_name": "antigen processing and presentation of endogenous peptide antigen via MHC class I", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1818020", "aliases": [], "types": ["T043"], "canonical_name": "antigen presentation, endogenous peptide antigen"}
{"concept_id": "C1818021", "aliases": ["exogenous peptide antigen processing and presentation via MHC class II"], "types": ["T043"], "canonical_name": "antigen processing and presentation of exogenous peptide antigen via MHC class II", "definition": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. [GOC:add, ISBN:0781735149, PMID:15771591]"}
{"concept_id": "C1818022", "aliases": [], "types": ["T044"], "canonical_name": "protein-ligand-dependent protein catabolic process"}
{"concept_id": "C1818023", "aliases": [], "types": ["T026"], "canonical_name": "tubulovesicular network"}
{"concept_id": "C1818024", "aliases": [], "types": ["T040"], "canonical_name": "evasion or tolerance of host immune response"}
{"concept_id": "C1818025", "aliases": [], "types": ["T040"], "canonical_name": "prechordal plate formation", "definition": "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818026", "aliases": [], "types": ["T040"], "canonical_name": "neural fold elevation formation", "definition": "The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]"}
{"concept_id": "C1818027", "aliases": [], "types": ["T040"], "canonical_name": "neural fold bending", "definition": "The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]"}
{"concept_id": "C1818028", "aliases": [], "types": ["T040"], "canonical_name": "neural fold hinge point formation", "definition": "The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586]"}
{"concept_id": "C1818029", "aliases": [], "types": ["T040"], "canonical_name": "neural fold furrowing"}
{"concept_id": "C1818030", "aliases": [], "types": ["T040"], "canonical_name": "neural fold folding", "definition": "The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586]"}
{"concept_id": "C1818031", "aliases": [], "types": ["T040"], "canonical_name": "anterior neuropore closure", "definition": "The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818032", "aliases": [], "types": ["T040"], "canonical_name": "posterior neuropore closure", "definition": "The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818033", "aliases": [], "types": ["T040"], "canonical_name": "floor plate formation", "definition": "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818034", "aliases": [], "types": ["T040"], "canonical_name": "roof plate formation", "definition": "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15936325]"}
{"concept_id": "C1818035", "aliases": [], "types": ["T042"], "canonical_name": "spinal cord development", "definition": "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818036", "aliases": [], "types": ["T042"], "canonical_name": "spinal cord patterning", "definition": "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818037", "aliases": ["spinal cord anterior-posterior patterning"], "types": ["T040"], "canonical_name": "spinal cord anterior/posterior patterning", "definition": "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818038", "aliases": [], "types": ["T040"], "canonical_name": "spinal cord rostrocaudal patterning"}
{"concept_id": "C1818039", "aliases": ["spinal cord dorsal-ventral patterning", "spinal cord dorsoventral patterning"], "types": ["T042"], "canonical_name": "spinal cord dorsal/ventral patterning", "definition": "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818040", "aliases": [], "types": ["T043"], "canonical_name": "ventral spinal cord interneuron differentiation", "definition": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818041", "aliases": [], "types": ["T043"], "canonical_name": "cell differentiation in spinal cord", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818042", "aliases": [], "types": ["T042"], "canonical_name": "dorsal spinal cord development", "definition": "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11179871]"}
{"concept_id": "C1818043", "aliases": [], "types": ["T042"], "canonical_name": "ventral spinal cord development", "definition": "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818044", "aliases": [], "types": ["T043"], "canonical_name": "spinal cord commissural neuron specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818045", "aliases": [], "types": ["T043"], "canonical_name": "spinal cord association neuron specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818046", "aliases": [], "types": ["T043"], "canonical_name": "spinal cord motor neuron cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818047", "aliases": [], "types": ["T043"], "canonical_name": "ventral spinal cord interneuron specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818048", "aliases": [], "types": ["T043"], "canonical_name": "spinal cord motor neuron differentiation", "definition": "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818049", "aliases": [], "types": ["T043"], "canonical_name": "somatic motor neuron differentiation", "definition": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818050", "aliases": [], "types": ["T043"], "canonical_name": "visceral motor neuron differentiation", "definition": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818051", "aliases": [], "types": ["T043"], "canonical_name": "lateral motor column neuron differentiation", "definition": "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818052", "aliases": [], "types": ["T043"], "canonical_name": "medial motor column neuron differentiation", "definition": "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818053", "aliases": ["spinal cord dorsal interneuron differentiation"], "types": ["T043"], "canonical_name": "spinal cord association neuron differentiation", "definition": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818054", "aliases": [], "types": ["T043"], "canonical_name": "commissural neuron differentiation in spinal cord", "definition": "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818055", "aliases": [], "types": ["T043"], "canonical_name": "spinal cord oligodendrocyte cell differentiation", "definition": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818056", "aliases": [], "types": ["T043"], "canonical_name": "spinal cord oligodendrocyte cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818057", "aliases": ["radial glial cell differentiation in spinal cord"], "types": ["T043"], "canonical_name": "spinal cord radial glial cell differentiation", "definition": "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16185248]"}
{"concept_id": "C1818058", "aliases": [], "types": ["T042"], "canonical_name": "neural tube patterning", "definition": "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818059", "aliases": [], "types": ["T043"], "canonical_name": "cell differentiation in hindbrain", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818060", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation in hindbrain", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818061", "aliases": [], "types": ["T043"], "canonical_name": "cell migration in hindbrain", "definition": "The orderly movement of a cell that will reside in the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818062", "aliases": [], "types": ["T042"], "canonical_name": "diencephalon development", "definition": "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818063", "aliases": ["cerebrum development"], "types": ["T042"], "canonical_name": "telencephalon development", "definition": "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818064", "aliases": [], "types": ["T042"], "canonical_name": "epithalamus development", "definition": "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818065", "aliases": [], "types": ["T042"], "canonical_name": "subthalamus development", "definition": "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818066", "aliases": [], "types": ["T042"], "canonical_name": "ventral thalamus development"}
{"concept_id": "C1818067", "aliases": [], "types": ["T042"], "canonical_name": "corpus callosum morphogenesis", "definition": "The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818068", "aliases": [], "types": ["T042"], "canonical_name": "ammon gyrus development", "definition": "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818069", "aliases": [], "types": ["T042"], "canonical_name": "Ammon's horn development"}
{"concept_id": "C1818070", "aliases": [], "types": ["T042"], "canonical_name": "cornu ammonis development"}
{"concept_id": "C1818071", "aliases": [], "types": ["T042"], "canonical_name": "dentate gyrus development", "definition": "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818072", "aliases": [], "types": ["T042"], "canonical_name": "pallium development", "definition": "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818073", "aliases": [], "types": ["T042"], "canonical_name": "subpallium development", "definition": "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818074", "aliases": [], "types": ["T042"], "canonical_name": "cranial nerve development", "definition": "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818075", "aliases": [], "types": ["T042"], "canonical_name": "rhombomere development", "definition": "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818076", "aliases": ["midbrain-hindbrain boundary biosynthesis", "MHB formation", "midbrain-hindbrain boundary formation", "MHB biosynthesis"], "types": ["T042"], "canonical_name": "midbrain-hindbrain boundary initiation", "definition": "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:15541513]"}
{"concept_id": "C1818077", "aliases": ["isthmus formation"], "types": ["T042"], "canonical_name": "isthmus biosynthesis"}
{"concept_id": "C1818078", "aliases": [], "types": ["T042"], "canonical_name": "pons development", "definition": "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818079", "aliases": [], "types": ["T042"], "canonical_name": "cerebellum development", "definition": "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818080", "aliases": [], "types": ["T042"], "canonical_name": "medulla oblongata development", "definition": "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818081", "aliases": [], "types": ["T042"], "canonical_name": "medulla development"}
{"concept_id": "C1818082", "aliases": [], "types": ["T042"], "canonical_name": "myelencephalon development"}
{"concept_id": "C1818083", "aliases": [], "types": ["T040"], "canonical_name": "central nervous system morphogenesis", "definition": "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]"}
{"concept_id": "C1818084", "aliases": ["MHB structural organization", "midbrain-hindbrain boundary structural organisation"], "types": ["T042"], "canonical_name": "midbrain-hindbrain boundary structural organization", "definition": "The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]"}
{"concept_id": "C1818085", "aliases": [], "types": ["T040"], "canonical_name": "isthmus structural organization"}
{"concept_id": "C1818086", "aliases": ["CN 1 development", "cranial nerve I development", "cranial nerve 1 development"], "types": ["T042"], "canonical_name": "olfactory nerve development", "definition": "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818087", "aliases": ["cranial nerve II development", "CN II development", "cranial nerve 2 development"], "types": ["T042"], "canonical_name": "optic nerve development", "definition": "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818088", "aliases": ["isthmus morphogenesis", "MHB morphogenesis"], "types": ["T040"], "canonical_name": "midbrain-hindbrain boundary morphogenesis", "definition": "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]"}
{"concept_id": "C1818089", "aliases": [], "types": ["T040"], "canonical_name": "central nervous system formation", "definition": "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]"}
{"concept_id": "C1818090", "aliases": ["CN III development", "cranial nerve III development", "cranial nerve 3 development"], "types": ["T042"], "canonical_name": "oculomotor nerve development", "definition": "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818091", "aliases": ["cranial nerve IV development", "CN IV development", "cranial nerve 4 development"], "types": ["T042"], "canonical_name": "trochlear nerve development", "definition": "The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818092", "aliases": ["cranial nerve V development", "CN V development", "cranial nerve 5 development"], "types": ["T042"], "canonical_name": "trigeminal nerve development", "definition": "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818093", "aliases": ["cranial nerve 6 development", "cranial nerve VI development", "CN VI development"], "types": ["T042"], "canonical_name": "abducens nerve development", "definition": "The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818094", "aliases": ["cranial nerve VII development", "cranial nerve 7 development", "CN VII development"], "types": ["T042"], "canonical_name": "facial nerve development", "definition": "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818095", "aliases": ["acoustic nerve development", "cranial nerve VIII development", "CN VIII development", "cranial nerve 8 development"], "types": ["T042"], "canonical_name": "vestibulocochlear nerve development", "definition": "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818096", "aliases": ["cranial nerve 9 development", "CN IX development", "cranial nerve IX development"], "types": ["T042"], "canonical_name": "glossopharyngeal nerve development", "definition": "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818097", "aliases": ["cranial nerve X development", "cranial nerve 10 development", "CN X development"], "types": ["T042"], "canonical_name": "vagus nerve development", "definition": "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818098", "aliases": ["CN XI development", "spinal accessory nerve development", "cranial nerve 11 development", "cranial nerve XI development"], "types": ["T042"], "canonical_name": "accessory nerve development", "definition": "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818099", "aliases": ["CN XII development", "cranial nerve 12 development", "cranial nerve XII development"], "types": ["T042"], "canonical_name": "hypoglossal nerve development", "definition": "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818100", "aliases": [], "types": ["T042"], "canonical_name": "rhombomere 1 development", "definition": "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818101", "aliases": [], "types": ["T042"], "canonical_name": "rhombomere 2 development", "definition": "The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818102", "aliases": [], "types": ["T042"], "canonical_name": "rhombomere 3 development", "definition": "The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818103", "aliases": [], "types": ["T042"], "canonical_name": "rhombomere 4 development", "definition": "The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818104", "aliases": [], "types": ["T042"], "canonical_name": "rhombomere 5 development", "definition": "The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818105", "aliases": [], "types": ["T042"], "canonical_name": "rhombomere 6 development", "definition": "The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818106", "aliases": [], "types": ["T042"], "canonical_name": "rhombomere 7 development", "definition": "The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818107", "aliases": [], "types": ["T042"], "canonical_name": "rhombomere 8 development", "definition": "The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818108", "aliases": [], "types": ["T040"], "canonical_name": "hindbrain morphogenesis", "definition": "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818109", "aliases": [], "types": ["T040"], "canonical_name": "rhombencephalon morphogenesis"}
{"concept_id": "C1818110", "aliases": [], "types": ["T040"], "canonical_name": "hindbrain formation", "definition": "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818111", "aliases": ["hindbrain structural organisation"], "types": ["T042"], "canonical_name": "hindbrain structural organization", "definition": "The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818112", "aliases": [], "types": ["T042"], "canonical_name": "hindbrain maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818113", "aliases": [], "types": ["T040"], "canonical_name": "medulla oblongata morphogenesis", "definition": "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818114", "aliases": [], "types": ["T040"], "canonical_name": "medulla morphogenesis"}
{"concept_id": "C1818115", "aliases": [], "types": ["T040"], "canonical_name": "myelencephalon morphogenesis"}
{"concept_id": "C1818116", "aliases": [], "types": ["T040"], "canonical_name": "medulla oblongata formation", "definition": "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818117", "aliases": [], "types": ["T040"], "canonical_name": "medulla biosynthesis"}
{"concept_id": "C1818118", "aliases": [], "types": ["T040"], "canonical_name": "medulla formation"}
{"concept_id": "C1818119", "aliases": [], "types": ["T040"], "canonical_name": "myelencephalon biosynthesis"}
{"concept_id": "C1818120", "aliases": [], "types": ["T040"], "canonical_name": "myelencephalon formation"}
{"concept_id": "C1818121", "aliases": ["medulla oblongata structural organisation", "medulla structural maturation"], "types": ["T040"], "canonical_name": "medulla oblongata structural organization", "definition": "The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818123", "aliases": [], "types": ["T040"], "canonical_name": "myelencephalon structural maturation"}
{"concept_id": "C1818124", "aliases": [], "types": ["T042"], "canonical_name": "medulla oblongata maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818125", "aliases": [], "types": ["T042"], "canonical_name": "medulla maturation"}
{"concept_id": "C1818126", "aliases": [], "types": ["T042"], "canonical_name": "myelencephalon maturation"}
{"concept_id": "C1818127", "aliases": [], "types": ["T040"], "canonical_name": "pons morphogenesis", "definition": "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818128", "aliases": [], "types": ["T040"], "canonical_name": "pons formation", "definition": "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818129", "aliases": ["pons structural organisation"], "types": ["T040"], "canonical_name": "pons structural organization", "definition": "The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818130", "aliases": [], "types": ["T042"], "canonical_name": "pons maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818131", "aliases": [], "types": ["T040"], "canonical_name": "cerebellum morphogenesis", "definition": "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818132", "aliases": [], "types": ["T040"], "canonical_name": "cerebellum formation", "definition": "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818133", "aliases": ["cerebellum structural organisation"], "types": ["T040"], "canonical_name": "cerebellum structural organization", "definition": "The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818134", "aliases": [], "types": ["T042"], "canonical_name": "cerebellum maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818135", "aliases": [], "types": ["T042"], "canonical_name": "ventricular system development", "definition": "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818136", "aliases": [], "types": ["T042"], "canonical_name": "fourth ventricle development", "definition": "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818137", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere morphogenesis", "definition": "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818138", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere formation", "definition": "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818139", "aliases": ["rhombomere structural organisation"], "types": ["T040"], "canonical_name": "rhombomere structural organization", "definition": "The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818140", "aliases": ["central nervous system structural organisation"], "types": ["T040"], "canonical_name": "central nervous system structural organization", "definition": "The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]"}
{"concept_id": "C1818141", "aliases": [], "types": ["T040"], "canonical_name": "abducens nerve morphogenesis", "definition": "The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818142", "aliases": [], "types": ["T040"], "canonical_name": "CN VI biosynthesis"}
{"concept_id": "C1818143", "aliases": ["CN VI formation"], "types": ["T040"], "canonical_name": "abducens nerve formation", "definition": "The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818144", "aliases": ["CN VI structural organization", "abducens nerve structural organisation"], "types": ["T042"], "canonical_name": "abducens nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818145", "aliases": ["CN VI maturation"], "types": ["T042"], "canonical_name": "abducens nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818146", "aliases": [], "types": ["T040"], "canonical_name": "cranial nerve morphogenesis", "definition": "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818147", "aliases": [], "types": ["T040"], "canonical_name": "cranial nerve formation", "definition": "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818148", "aliases": ["cranial nerve structural organisation"], "types": ["T042"], "canonical_name": "cranial nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818149", "aliases": [], "types": ["T042"], "canonical_name": "cranial nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818150", "aliases": ["CN XI maturation"], "types": ["T042"], "canonical_name": "accessory nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818151", "aliases": [], "types": ["T042"], "canonical_name": "spinal accessory nerve maturation"}
{"concept_id": "C1818152", "aliases": ["CN XI morphogenesis"], "types": ["T040"], "canonical_name": "accessory nerve morphogenesis", "definition": "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818153", "aliases": [], "types": ["T040"], "canonical_name": "CN XI biosynthesis"}
{"concept_id": "C1818154", "aliases": ["CN XI formation"], "types": ["T040"], "canonical_name": "accessory nerve formation", "definition": "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818155", "aliases": ["CN XI structural organization", "accessory nerve structural organisation"], "types": ["T042"], "canonical_name": "accessory nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818156", "aliases": ["CN VII morphogenesis"], "types": ["T040"], "canonical_name": "facial nerve morphogenesis", "definition": "The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818157", "aliases": [], "types": ["T040"], "canonical_name": "CN VII biosynthesis"}
{"concept_id": "C1818158", "aliases": ["CN VII formation", "vestibulocochlear nerve formation"], "types": ["T040"], "canonical_name": "facial nerve formation", "definition": "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818159", "aliases": ["facial nerve structural organisation", "vestibulocochlear nerve structural organisation", "vestibulocochlear nerve structural organization", "CN VII structural organization"], "types": ["T042"], "canonical_name": "facial nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818160", "aliases": ["CN VII maturation"], "types": ["T042"], "canonical_name": "facial nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818161", "aliases": ["CN IX maturation"], "types": ["T042"], "canonical_name": "glossopharyngeal nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818162", "aliases": ["CN IX morphogenesis"], "types": ["T040"], "canonical_name": "glossopharyngeal nerve morphogenesis", "definition": "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818163", "aliases": [], "types": ["T040"], "canonical_name": "CN IX biosynthesis"}
{"concept_id": "C1818164", "aliases": ["CN IX formation"], "types": ["T040"], "canonical_name": "glossopharyngeal nerve formation", "definition": "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818165", "aliases": ["CN IX structural organization", "glossopharyngeal nerve structural organisation"], "types": ["T042"], "canonical_name": "glossopharyngeal nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818166", "aliases": ["CN XII morphogenesis"], "types": ["T040"], "canonical_name": "hypoglossal nerve morphogenesis", "definition": "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818167", "aliases": ["CN XII maturation"], "types": ["T042"], "canonical_name": "hypoglossal nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818168", "aliases": [], "types": ["T040"], "canonical_name": "CN XII biosynthesis"}
{"concept_id": "C1818169", "aliases": ["CN XII formation"], "types": ["T040"], "canonical_name": "hypoglossal nerve formation", "definition": "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818170", "aliases": ["CN XII structural organization", "hypoglossal nerve structural organisation"], "types": ["T042"], "canonical_name": "hypoglossal nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818171", "aliases": ["CN III morphogenesis"], "types": ["T040"], "canonical_name": "oculomotor nerve morphogenesis", "definition": "The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818172", "aliases": [], "types": ["T040"], "canonical_name": "CN III biosynthesis"}
{"concept_id": "C1818173", "aliases": ["CN III formation"], "types": ["T040"], "canonical_name": "oculomotor nerve formation", "definition": "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818174", "aliases": ["CN III structural organization", "oculomotor nerve structural organisation"], "types": ["T042"], "canonical_name": "oculomotor nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818175", "aliases": ["CN III maturation"], "types": ["T042"], "canonical_name": "oculomotor nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818176", "aliases": [], "types": ["T042"], "canonical_name": "central nervous system maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]"}
{"concept_id": "C1818177", "aliases": ["CN I morphogenesis"], "types": ["T040"], "canonical_name": "olfactory nerve morphogenesis", "definition": "The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818178", "aliases": [], "types": ["T040"], "canonical_name": "CN I biosynthesis"}
{"concept_id": "C1818179", "aliases": ["CN I formation"], "types": ["T040"], "canonical_name": "olfactory nerve formation", "definition": "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818180", "aliases": ["CN I structural organization", "olfactory nerve structural organisation"], "types": ["T042"], "canonical_name": "olfactory nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818181", "aliases": ["CN I maturation"], "types": ["T042"], "canonical_name": "olfactory nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818182", "aliases": ["CN II morphogenesis"], "types": ["T040"], "canonical_name": "optic nerve morphogenesis", "definition": "The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818183", "aliases": ["CN II maturation"], "types": ["T042"], "canonical_name": "optic nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818184", "aliases": ["optic nerve structural organisation", "CN II structural organization"], "types": ["T042"], "canonical_name": "optic nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818185", "aliases": [], "types": ["T040"], "canonical_name": "CN II biosynthesis"}
{"concept_id": "C1818186", "aliases": ["CN II formation"], "types": ["T040"], "canonical_name": "optic nerve formation", "definition": "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818187", "aliases": ["CN V maturation"], "types": ["T042"], "canonical_name": "trigeminal nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818188", "aliases": ["CN V morphogenesis"], "types": ["T040"], "canonical_name": "trigeminal nerve morphogenesis", "definition": "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818189", "aliases": ["CN V structural organization", "trigeminal nerve structural organisation"], "types": ["T042"], "canonical_name": "trigeminal nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818190", "aliases": [], "types": ["T040"], "canonical_name": "CN V biosynthesis"}
{"concept_id": "C1818191", "aliases": ["CN V formation"], "types": ["T040"], "canonical_name": "trigeminal nerve formation", "definition": "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818192", "aliases": ["CH IV morphogenesis"], "types": ["T040"], "canonical_name": "trochlear nerve morphogenesis", "definition": "The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818193", "aliases": ["CN IV maturation"], "types": ["T042"], "canonical_name": "trochlear nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818194", "aliases": ["CN IV structural organization", "trochlear nerve structural organisation"], "types": ["T042"], "canonical_name": "trochlear nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818195", "aliases": [], "types": ["T040"], "canonical_name": "CN IV biosynthesis"}
{"concept_id": "C1818196", "aliases": ["CN IV formation"], "types": ["T040"], "canonical_name": "trochlear nerve formation", "definition": "The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818197", "aliases": ["CN X maturation"], "types": ["T042"], "canonical_name": "vagus nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818198", "aliases": ["CN X morphogenesis"], "types": ["T040"], "canonical_name": "vagus nerve morphogenesis", "definition": "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818199", "aliases": ["vagus nerve structural organisation", "CN X structural organization"], "types": ["T042"], "canonical_name": "vagus nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818200", "aliases": [], "types": ["T040"], "canonical_name": "CN X biosynthesis"}
{"concept_id": "C1818201", "aliases": ["CN X formation"], "types": ["T040"], "canonical_name": "vagus nerve formation", "definition": "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818202", "aliases": ["CN VIII maturation", "auditory nerve maturation"], "types": ["T042"], "canonical_name": "vestibulocochlear nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818203", "aliases": ["CN VIII morphogenesis"], "types": ["T040"], "canonical_name": "vestibulocochlear nerve morphogenesis", "definition": "The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818206", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 1 morphogenesis", "definition": "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818207", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 1 formation", "definition": "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818208", "aliases": ["rhombomere 1 structural organisation"], "types": ["T042"], "canonical_name": "rhombomere 1 structural organization", "definition": "The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818209", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere boundary formation", "definition": "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818210", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 2 morphogenesis", "definition": "The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818211", "aliases": ["rhombomere 2 structural organisation"], "types": ["T042"], "canonical_name": "rhombomere 2 structural organization", "definition": "The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818212", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 2 formation", "definition": "The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818213", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 3 morphogenesis", "definition": "The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818214", "aliases": ["rhombomere 3 structural organisation"], "types": ["T042"], "canonical_name": "rhombomere 3 structural organization", "definition": "The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818215", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 3 formation", "definition": "The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818216", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 4 morphogenesis", "definition": "The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818217", "aliases": ["rhombomere 4 structural organisation"], "types": ["T042"], "canonical_name": "rhombomere 4 structural organization", "definition": "The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818218", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 4 formation", "definition": "The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818219", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 5 morphogenesis", "definition": "The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818220", "aliases": ["rhombomere 5 structural organisation"], "types": ["T042"], "canonical_name": "rhombomere 5 structural organization", "definition": "The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818221", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 5 formation", "definition": "The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818222", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 6 morphogenesis", "definition": "The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818223", "aliases": ["rhombomere 6 structural organisation"], "types": ["T042"], "canonical_name": "rhombomere 6 structural organization", "definition": "The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818224", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 6 formation", "definition": "The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818225", "aliases": [], "types": ["T042"], "canonical_name": "lateral ventricle development", "definition": "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818226", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 7 morphogenesis", "definition": "The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818227", "aliases": ["rhombomere 7 structural organisation"], "types": ["T042"], "canonical_name": "rhombomere 7 structural organization", "definition": "The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818228", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 7 formation", "definition": "The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818229", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 8 morphogenesis", "definition": "The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818230", "aliases": [], "types": ["T042"], "canonical_name": "nerve development", "definition": "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818231", "aliases": ["rhombomere 8 structural organisation"], "types": ["T042"], "canonical_name": "rhombomere 8 structural organization", "definition": "The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818232", "aliases": [], "types": ["T040"], "canonical_name": "rhombomere 8 formation", "definition": "The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818233", "aliases": [], "types": ["T042"], "canonical_name": "third ventricle development", "definition": "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818234", "aliases": [], "types": ["T042"], "canonical_name": "cerebellar molecular layer development", "definition": "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818235", "aliases": [], "types": ["T042"], "canonical_name": "cerebellar Purkinje cell layer development", "definition": "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818236", "aliases": [], "types": ["T042"], "canonical_name": "cerebellar granular layer development", "definition": "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818237", "aliases": [], "types": ["T042"], "canonical_name": "nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818238", "aliases": [], "types": ["T040"], "canonical_name": "cerebellar granular layer morphogenesis", "definition": "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818239", "aliases": [], "types": ["T040"], "canonical_name": "cerebellar granular layer formation", "definition": "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818240", "aliases": ["cerebellar granular layer structural organisation"], "types": ["T042"], "canonical_name": "cerebellar granular layer structural organization", "definition": "The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818241", "aliases": [], "types": ["T042"], "canonical_name": "cerebellar granular layer maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818242", "aliases": [], "types": ["T040"], "canonical_name": "cerebellar molecular layer morphogenesis", "definition": "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818243", "aliases": [], "types": ["T040"], "canonical_name": "cerebellar molecular layer formation", "definition": "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818244", "aliases": ["cerebellar molecular layer structural organisation"], "types": ["T042"], "canonical_name": "cerebellar molecular layer structural organization", "definition": "The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818245", "aliases": [], "types": ["T042"], "canonical_name": "cerebellar molecular layer maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818246", "aliases": [], "types": ["T040"], "canonical_name": "cerebellar Purkinje cell layer maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818247", "aliases": [], "types": ["T040"], "canonical_name": "cerebellar Purkinje cell layer morphogenesis", "definition": "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818248", "aliases": ["cerebellar Purkinje cell layer structural organisation"], "types": ["T042"], "canonical_name": "cerebellar Purkinje cell layer structural organization", "definition": "The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818249", "aliases": [], "types": ["T040"], "canonical_name": "cerebellar Purkinje cell layer formation", "definition": "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818250", "aliases": [], "types": ["T042"], "canonical_name": "cerebellar cortex development", "definition": "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818251", "aliases": [], "types": ["T040"], "canonical_name": "cerebellar cortex morphogenesis", "definition": "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818252", "aliases": [], "types": ["T040"], "canonical_name": "cerebellar cortex formation", "definition": "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818253", "aliases": ["cerebellar cortex structural organisation"], "types": ["T042"], "canonical_name": "cerebellar cortex structural organization", "definition": "The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818254", "aliases": [], "types": ["T042"], "canonical_name": "cerebellar cortex maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818255", "aliases": [], "types": ["T042"], "canonical_name": "developmental maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818256", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar Golgi cell differentiation", "definition": "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818257", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar Purkinje cell differentiation", "definition": "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818258", "aliases": ["locus coeruleus development", "locus caeruleus development"], "types": ["T042"], "canonical_name": "locus ceruleus development", "definition": "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818259", "aliases": [], "types": ["T040"], "canonical_name": "locus ceruleus morphogenesis", "definition": "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818260", "aliases": [], "types": ["T040"], "canonical_name": "locus ceruleus formation", "definition": "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818261", "aliases": [], "types": ["T042"], "canonical_name": "locus ceruleus maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818262", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar granule cell differentiation", "definition": "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818263", "aliases": [], "types": ["T043"], "canonical_name": "Lugaro cell differentiation", "definition": "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818264", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar basket cell differentiation", "definition": "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818265", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar stellate cell differentiation", "definition": "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818266", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar unipolar brush cell differentiation", "definition": "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818267", "aliases": [], "types": ["T043"], "canonical_name": "candelabrum cell differentiation", "definition": "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818268", "aliases": [], "types": ["T042"], "canonical_name": "inferior olivary nucleus development", "definition": "The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818269", "aliases": [], "types": ["T042"], "canonical_name": "inferior olive development"}
{"concept_id": "C1818270", "aliases": [], "types": ["T040"], "canonical_name": "inferior olivary nucleus morphogenesis", "definition": "The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818271", "aliases": [], "types": ["T040"], "canonical_name": "inferior olive morphogenesis"}
{"concept_id": "C1818272", "aliases": [], "types": ["T040"], "canonical_name": "inferior olivary nucleus formation", "definition": "The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818273", "aliases": [], "types": ["T040"], "canonical_name": "inferior olive biosynthesis"}
{"concept_id": "C1818274", "aliases": [], "types": ["T040"], "canonical_name": "inferior olive formation"}
{"concept_id": "C1818275", "aliases": ["inferior olivary nucleus structural organisation"], "types": ["T042"], "canonical_name": "inferior olivary nucleus structural organization", "definition": "The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818276", "aliases": [], "types": ["T040"], "canonical_name": "inferior olive structural organization"}
{"concept_id": "C1818277", "aliases": [], "types": ["T042"], "canonical_name": "inferior olivary nucleus maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818278", "aliases": [], "types": ["T042"], "canonical_name": "inferior olive maturation"}
{"concept_id": "C1818279", "aliases": [], "types": ["T042"], "canonical_name": "superior olivary nucleus development", "definition": "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818280", "aliases": [], "types": ["T042"], "canonical_name": "superior olive development"}
{"concept_id": "C1818281", "aliases": [], "types": ["T040"], "canonical_name": "superior olivary nucleus morphogenesis", "definition": "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818282", "aliases": [], "types": ["T040"], "canonical_name": "superior olive morphogenesis"}
{"concept_id": "C1818283", "aliases": [], "types": ["T040"], "canonical_name": "superior olivary nucleus formation", "definition": "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818284", "aliases": ["superior olivary nucleus structural organisation"], "types": ["T042"], "canonical_name": "superior olivary nucleus structural organization", "definition": "The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818285", "aliases": [], "types": ["T042"], "canonical_name": "superior olivary nucleus maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1818286", "aliases": [], "types": ["T042"], "canonical_name": "superior olive maturation"}
{"concept_id": "C1818287", "aliases": [], "types": ["T042"], "canonical_name": "rhombencephalic reticular formation development"}
{"concept_id": "C1818288", "aliases": [], "types": ["T042"], "canonical_name": "inferior raphe nucleus development", "definition": "The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, PMID:19003874, ZFA:0000366]"}
{"concept_id": "C1818289", "aliases": [], "types": ["T042"], "canonical_name": "superior raphe nucleus development", "definition": "The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, PMID:19003874, ZFA:0000440]"}
{"concept_id": "C1818290", "aliases": [], "types": ["T042"], "canonical_name": "lateral reticular nucleus development", "definition": "The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818291", "aliases": ["intermediate reticular nucleus development"], "types": ["T042"], "canonical_name": "intermediate reticular formation development", "definition": "The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818292", "aliases": [], "types": ["T042"], "canonical_name": "inferior reticular formation development", "definition": "The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818293", "aliases": [], "types": ["T042"], "canonical_name": "superior reticular formation development", "definition": "The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818294", "aliases": [], "types": ["T042"], "canonical_name": "trigeminal sensory nucleus development", "definition": "The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818295", "aliases": [], "types": ["T042"], "canonical_name": "trigeminal motor nucleus development", "definition": "The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818296", "aliases": [], "types": ["T042"], "canonical_name": "midbrain-hindbrain boundary maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]"}
{"concept_id": "C1818297", "aliases": [], "types": ["T042"], "canonical_name": "isthmus maturation"}
{"concept_id": "C1818298", "aliases": [], "types": ["T042"], "canonical_name": "MHB maturation"}
{"concept_id": "C1818301", "aliases": [], "types": ["T042"], "canonical_name": "dentate nucleus development", "definition": "The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818302", "aliases": [], "types": ["T042"], "canonical_name": "globose nucleus development", "definition": "The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818303", "aliases": [], "types": ["T042"], "canonical_name": "emboliform nucleus development", "definition": "The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818304", "aliases": [], "types": ["T042"], "canonical_name": "fastigial nucleus development", "definition": "The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818305", "aliases": [], "types": ["T042"], "canonical_name": "mesencephalic trigeminal nucleus development", "definition": "The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818306", "aliases": [], "types": ["T042"], "canonical_name": "pontine nucleus development"}
{"concept_id": "C1818307", "aliases": [], "types": ["T042"], "canonical_name": "spinal trigeminal nucleus development", "definition": "The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818308", "aliases": [], "types": ["T042"], "canonical_name": "abducens nucleus development", "definition": "The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818309", "aliases": [], "types": ["T042"], "canonical_name": "hypoglossal nucleus development", "definition": "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818310", "aliases": [], "types": ["T042"], "canonical_name": "dorsal motor nucleus of vagus nerve development", "definition": "The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818311", "aliases": [], "types": ["T042"], "canonical_name": "nucleus ambiguus development", "definition": "The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818312", "aliases": [], "types": ["T042"], "canonical_name": "solitary nucleus development", "definition": "The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818313", "aliases": [], "types": ["T042"], "canonical_name": "cochlear nucleus development", "definition": "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818314", "aliases": [], "types": ["T042"], "canonical_name": "dorsal cochlear nucleus development", "definition": "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818315", "aliases": [], "types": ["T042"], "canonical_name": "ventral cochlear nucleus development", "definition": "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818316", "aliases": [], "types": ["T042"], "canonical_name": "vestibular nucleus development", "definition": "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, PMID:16221589]"}
{"concept_id": "C1818317", "aliases": [], "types": ["T042"], "canonical_name": "salivary nucleus development", "definition": "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818318", "aliases": [], "types": ["T042"], "canonical_name": "inferior salivary nucleus development", "definition": "The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818319", "aliases": [], "types": ["T042"], "canonical_name": "superior salivary nucleus development", "definition": "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818320", "aliases": [], "types": ["T042"], "canonical_name": "facial nucleus development", "definition": "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818321", "aliases": [], "types": ["T043"], "canonical_name": "eurydendroid cell differentiation", "definition": "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15892096]"}
{"concept_id": "C1818322", "aliases": ["neostriatum development", "striate nucleus development"], "types": ["T042"], "canonical_name": "striatum development", "definition": "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818323", "aliases": [], "types": ["T042"], "canonical_name": "caudate nucleus development", "definition": "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818324", "aliases": [], "types": ["T042"], "canonical_name": "putamen development", "definition": "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818325", "aliases": ["pallidum development"], "types": ["T042"], "canonical_name": "globus pallidus development", "definition": "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818326", "aliases": [], "types": ["T042"], "canonical_name": "limbic system development", "definition": "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818327", "aliases": [], "types": ["T042"], "canonical_name": "substantia nigra development", "definition": "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420]"}
{"concept_id": "C1818328", "aliases": [], "types": ["T042"], "canonical_name": "subthalamic nucleus development", "definition": "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818329", "aliases": [], "types": ["T042"], "canonical_name": "corpus luysi development"}
{"concept_id": "C1818330", "aliases": [], "types": ["T042"], "canonical_name": "amygdala development", "definition": "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818331", "aliases": [], "types": ["T042"], "canonical_name": "cingulate gyrus development", "definition": "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818332", "aliases": ["hippocampal formation development"], "types": ["T042"], "canonical_name": "hippocampus development", "definition": "The progression of the hippocampus over time from its initial formation until its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421]"}
{"concept_id": "C1818333", "aliases": [], "types": ["T042"], "canonical_name": "mammillary body development", "definition": "The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818334", "aliases": ["accumbens nucleus development"], "types": ["T042"], "canonical_name": "nucleus accumbens development", "definition": "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818335", "aliases": [], "types": ["T042"], "canonical_name": "ventral striatum development"}
{"concept_id": "C1818336", "aliases": [], "types": ["T042"], "canonical_name": "orbitofrontal cortex development", "definition": "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818337", "aliases": ["LGN development"], "types": ["T042"], "canonical_name": "lateral geniculate nucleus development", "definition": "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818338", "aliases": [], "types": ["T042"], "canonical_name": "olfactory bulb development", "definition": "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818339", "aliases": ["striatal MSN differentiation", "medium-sized spiny neuron differentiation"], "types": ["T043"], "canonical_name": "striatal medium spiny neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818340", "aliases": ["retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification"], "types": ["T044"], "canonical_name": "retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification", "definition": "The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:sdb_2009, GOC:tb, PMID:11262869]"}
{"concept_id": "C1818341", "aliases": ["hedgehog signaling pathway involved in ventral spinal cord interneuron specification", "smoothened signalling pathway involved in ventral spinal cord interneuron specification", "hh signaling pathway involved in ventral spinal cord interneuron specification"], "types": ["T044"], "canonical_name": "smoothened signaling pathway involved in ventral spinal cord interneuron specification", "definition": "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818342", "aliases": ["hh signaling pathway involved in spinal cord motor neuron cell fate specification", "hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification", "smoothened signalling pathway involved in spinal cord motor neuron cell fate specification"], "types": ["T044"], "canonical_name": "smoothened signaling pathway involved in spinal cord motor neuron cell fate specification", "definition": "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15936325]"}
{"concept_id": "C1818344", "aliases": [], "types": ["T043"], "canonical_name": "oligodendrocyte cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818345", "aliases": [], "types": ["T043"], "canonical_name": "oligodendrocyte cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818346", "aliases": [], "types": ["T043"], "canonical_name": "glial cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818347", "aliases": [], "types": ["T043"], "canonical_name": "glial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818348", "aliases": [], "types": ["T043"], "canonical_name": "glial cell development", "definition": "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818349", "aliases": [], "types": ["T042"], "canonical_name": "preganglionic parasympathetic fiber development", "definition": "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion. [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818350", "aliases": [], "types": ["T042"], "canonical_name": "postganglionic parasympathetic fiber development", "definition": "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818351", "aliases": ["BMN axon guidance", "special visceral motor neuron axon guidance", "branchial motor axon guidance"], "types": ["T043"], "canonical_name": "branchiomotor neuron axon guidance", "definition": "The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]"}
{"concept_id": "C1818352", "aliases": [], "types": ["T043"], "canonical_name": "branchiomotor neuron axon guidance in neural tube", "definition": "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]"}
{"concept_id": "C1818353", "aliases": ["negative chemotaxis of branchiomotor neuron axon in neural tube"], "types": ["T043"], "canonical_name": "chemorepulsion of branchiomotor neuron axon in neural tube", "definition": "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]"}
{"concept_id": "C1818354", "aliases": ["positive chemotaxis of branchiomotor neuron axon in neural tube"], "types": ["T043"], "canonical_name": "chemoattraction of branchiomotor neuron axon in neural tube", "definition": "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]"}
{"concept_id": "C1818355", "aliases": [], "types": ["T043"], "canonical_name": "branchiomotor neuron axon guidance in branchial arch mesenchyme", "definition": "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]"}
{"concept_id": "C1818356", "aliases": ["negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme"], "types": ["T043"], "canonical_name": "chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme", "definition": "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]"}
{"concept_id": "C1818357", "aliases": ["positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme"], "types": ["T043"], "canonical_name": "chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme", "definition": "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]"}
{"concept_id": "C1818358", "aliases": ["positive chemotaxis of branchiomotor axon"], "types": ["T043"], "canonical_name": "chemoattraction of branchiomotor axon", "definition": "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]"}
{"concept_id": "C1818359", "aliases": ["negative chemotaxis of branchiomotor axon"], "types": ["T043"], "canonical_name": "chemorepulsion of branchiomotor axon", "definition": "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]"}
{"concept_id": "C1818360", "aliases": [], "types": ["T042"], "canonical_name": "thalamus development", "definition": "The process in which the thalamus changes over time, from its initial formation to its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818361", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex cell migration", "definition": "The orderly movement of cells from one site to another in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818362", "aliases": ["cerebral cortex arealization", "cerebral cortex pattern formation", "cerebral cortex pattern biosynthesis"], "types": ["T042"], "canonical_name": "cerebral cortex regionalization", "definition": "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818364", "aliases": ["forebrain dorsal-ventral pattern formation", "forebrain dorsoventral pattern formation"], "types": ["T042"], "canonical_name": "forebrain dorsal/ventral pattern formation", "definition": "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818366", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex tangential migration", "definition": "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818367", "aliases": ["cerebral cortex radial glia-dependent cell migration", "cerebral cortex radial glia guided migration"], "types": ["T043"], "canonical_name": "cerebral cortex radial glia-guided migration", "definition": "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818368", "aliases": [], "types": ["T043"], "canonical_name": "glial-guided locomotion"}
{"concept_id": "C1818369", "aliases": ["perikaryal translocation of Morest"], "types": ["T043"], "canonical_name": "somal translocation", "definition": "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818370", "aliases": [], "types": ["T043"], "canonical_name": "extension of leading cell process to pial surface", "definition": "The extension of a long process to the pial surface as a cell leaves the ventricular zone. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818371", "aliases": ["downregulation of cell adhesion in ventricular zone", "down regulation of cell adhesion in ventricular zone", "down-regulation of cell adhesion in ventricular zone"], "types": ["T043"], "canonical_name": "negative regulation of cell adhesion in ventricular zone", "definition": "The process that results in the loss of attachments of a cell in the ventricular zone. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818372", "aliases": ["cell motility involved in somal translocation"], "types": ["T043"], "canonical_name": "cell movement involved in somal translocation", "definition": "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818374", "aliases": ["motogenic signalling initiating cell movement in the cerebral cortex"], "types": ["T043"], "canonical_name": "motogenic signaling initiating cell movement in cerebral cortex", "definition": "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818375", "aliases": ["cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration"], "types": ["T043"], "canonical_name": "cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration", "definition": "The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818376", "aliases": ["neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration", "definition": "Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818377", "aliases": ["neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration", "definition": "Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818378", "aliases": ["growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration", "growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration", "definition": "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818381", "aliases": ["cell locomotion involved in cerebral cortex radial glia guided migration", "cell locomotion involved in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "cell motility involved in cerebral cortex radial glia guided migration", "definition": "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818384", "aliases": ["nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration", "nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration", "definition": "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695]"}
{"concept_id": "C1818386", "aliases": [], "types": ["T042"], "canonical_name": "layer formation in cerebral cortex", "definition": "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818387", "aliases": [], "types": ["T040"], "canonical_name": "cerebral cortex lamination"}
{"concept_id": "C1818389", "aliases": ["downregulation of cell-glial cell adhesion involved in cerebral cortex lamination", "down regulation of cell-glial cell adhesion involved in cerebral cortex lamination", "down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination"], "types": ["T043"], "canonical_name": "negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination", "definition": "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818391", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex tangential migration using cell-cell interactions", "definition": "The process in which neurons interact with each other to promote migration along a tangential plane. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818392", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex tangential migration using cell-axon interactions", "definition": "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818393", "aliases": [], "types": ["T043"], "canonical_name": "substrate-dependent cerebral cortex tangential migration", "definition": "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818394", "aliases": [], "types": ["T043"], "canonical_name": "substrate-independent telencephalic tangential migration", "definition": "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818395", "aliases": [], "types": ["T043"], "canonical_name": "postnatal olfactory bulb interneuron migration", "definition": "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818396", "aliases": ["gonadotropin-releasing hormone neuronal migration to the hypothalamus"], "types": ["T043"], "canonical_name": "gonadotrophin-releasing hormone neuronal migration to the hypothalamus", "definition": "The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818397", "aliases": [], "types": ["T043"], "canonical_name": "oligodendrocyte cell migration from the subpallium to the cortex", "definition": "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818398", "aliases": [], "types": ["T043"], "canonical_name": "interneuron migration from the subpallium to the cortex", "definition": "The directed movement of interneurons from the subpallium to the cortex during forebrain development. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818399", "aliases": [], "types": ["T043"], "canonical_name": "embryonic olfactory bulb interneuron precursor migration", "definition": "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818400", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions", "definition": "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818404", "aliases": ["negative chemotaxis involved in postnatal olfactory bulb interneuron migration"], "types": ["T043"], "canonical_name": "chemorepulsion involved in postnatal olfactory bulb interneuron migration", "definition": "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818405", "aliases": ["motogenic signalling involved in postnatal olfactory bulb interneuron migration"], "types": ["T043"], "canonical_name": "motogenic signaling involved in postnatal olfactory bulb interneuron migration", "definition": "The signaling that results in the stimulation of cell movement in the rostral migratory stream. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818406", "aliases": ["motogenic signalling involved in interneuron migration from the subpallium to the cortex"], "types": ["T043"], "canonical_name": "motogenic signaling involved in interneuron migration from the subpallium to the cortex", "definition": "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818407", "aliases": [], "types": ["T043"], "canonical_name": "interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex", "definition": "The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818408", "aliases": [], "types": ["T043"], "canonical_name": "directional guidance of interneurons involved in migration from the subpallium to the cortex", "definition": "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818409", "aliases": ["positive chemotaxis involved in interneuron migration from the subpallium to the cortex"], "types": ["T043"], "canonical_name": "chemoattraction involved in interneuron migration from the subpallium to the cortex", "definition": "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818410", "aliases": ["negative chemotaxis involved in interneuron migration from the subpallium to the cortex"], "types": ["T043"], "canonical_name": "chemorepulsion involved in interneuron migration from the subpallium to the cortex", "definition": "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818411", "aliases": [], "types": ["T043"], "canonical_name": "substrate-independent telencephalic tangential interneuron migration", "definition": "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818412", "aliases": [], "types": ["T043"], "canonical_name": "interneuron sorting involved in substrate-independent cerebral cortex tangential migration", "definition": "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818413", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration", "definition": "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818414", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation in forebrain", "definition": "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818415", "aliases": ["neuroblast division in ventricular zone"], "types": ["T043"], "canonical_name": "ventricular zone neuroblast division", "definition": "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818416", "aliases": ["neuroblast division in the ventral telencephalon"], "types": ["T043"], "canonical_name": "neuroblast division in subpallium", "definition": "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818417", "aliases": [], "types": ["T043"], "canonical_name": "neuroblast division in subventricular zone", "definition": "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818418", "aliases": ["glioblast cell division in subpallium", "glioblast division in ventral telencephalon"], "types": ["T043"], "canonical_name": "subpallium glioblast cell division", "definition": "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818419", "aliases": [], "types": ["T043"], "canonical_name": "neuroblast division in dorsal lateral ganglionic eminence", "definition": "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818420", "aliases": [], "types": ["T043"], "canonical_name": "pyramidal neuron migration"}
{"concept_id": "C1818421", "aliases": [], "types": ["T043"], "canonical_name": "projection neuron migration"}
{"concept_id": "C1818422", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex GABAergic interneuron migration", "definition": "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818423", "aliases": [], "types": ["T042"], "canonical_name": "hypothalamus development", "definition": "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818424", "aliases": [], "types": ["T043"], "canonical_name": "hypothalamus cell migration", "definition": "The directed movement of a cell into the hypothalamus region of the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818425", "aliases": [], "types": ["T043"], "canonical_name": "hypothalamic tangential migration using cell-axon interactions", "definition": "The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818426", "aliases": [], "types": ["T043"], "canonical_name": "GABAergic neuron differentiation in basal ganglia", "definition": "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818427", "aliases": [], "types": ["T043"], "canonical_name": "pyramidal neuron differentiation", "definition": "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818428", "aliases": [], "types": ["T043"], "canonical_name": "projection neuron differentiation"}
{"concept_id": "C1818429", "aliases": [], "types": ["T043"], "canonical_name": "pyramidal neuron development", "definition": "The progression of a pyramidal neuron from its initial formation to its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818430", "aliases": [], "types": ["T043"], "canonical_name": "projection neuron development"}
{"concept_id": "C1818431", "aliases": ["radial glial cell differentiation in forebrain"], "types": ["T043"], "canonical_name": "forebrain radial glial cell differentiation", "definition": "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818432", "aliases": [], "types": ["T043"], "canonical_name": "early neuron differentiation in forebrain", "definition": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818433", "aliases": ["abventricular progenitor cell differentiation", "intermediate progenitor cell differentiation", "non-surface dividing progenitor cell differentiation"], "types": ["T043"], "canonical_name": "forebrain neuroblast differentiation", "definition": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818439", "aliases": [], "types": ["T043"], "canonical_name": "forebrain ventricular zone progenitor cell division", "definition": "The mitotic division of a basal progenitor giving rise to two neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818440", "aliases": [], "types": ["T043"], "canonical_name": "Cajal-Retzius cell differentiation", "definition": "The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818441", "aliases": [], "types": ["T042"], "canonical_name": "forebrain regionalization", "definition": "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818442", "aliases": ["generation of neurons in forebrain"], "types": ["T040"], "canonical_name": "forebrain generation of neurons", "definition": "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818443", "aliases": [], "types": ["T043"], "canonical_name": "forebrain neuroblast division", "definition": "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818444", "aliases": ["Wnt receptor signalling pathway in forebrain neuroblast division", "Wnt-activated signaling pathway involved in forebrain neuroblast division", "Wnt receptor signaling pathway involved in forebrain neuroblast division"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in forebrain neuroblast division", "definition": "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818445", "aliases": ["fibroblast growth factor receptor signalling pathway in forebrain neuroblast division"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818446", "aliases": ["Notch signalling pathway in forebrain neuroblast division"], "types": ["T044"], "canonical_name": "Notch signaling pathway involved in forebrain neuroblast division", "definition": "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818447", "aliases": [], "types": ["T043"], "canonical_name": "forebrain neuron fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818448", "aliases": [], "types": ["T043"], "canonical_name": "forebrain astrocyte fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818449", "aliases": [], "types": ["T043"], "canonical_name": "forebrain neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818450", "aliases": ["Notch signalling pathway involved in forebrain neuron fate commitment"], "types": ["T044"], "canonical_name": "Notch signaling pathway involved in forebrain neuron fate commitment", "definition": "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818451", "aliases": ["Wnt receptor signaling pathway involved in forebrain neuron fate commitment", "Wnt receptor signalling pathway involved in forebrain neuron fate commitment"], "types": ["T044"], "canonical_name": "Wnt-activated signaling pathway involved in forebrain neuron fate commitment", "definition": "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818454", "aliases": [], "types": ["T043"], "canonical_name": "forebrain neuron development", "definition": "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818455", "aliases": [], "types": ["T043"], "canonical_name": "forebrain cell migration", "definition": "The orderly movement of a cell from one site to another at least one of which is located in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818456", "aliases": ["hypothalamus gonadotropin-releasing hormone neuron differentiation"], "types": ["T043"], "canonical_name": "hypothalamus gonadotrophin-releasing hormone neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818457", "aliases": ["hypothalamus gonadotropin-releasing hormone neuron fate commitment"], "types": ["T043"], "canonical_name": "hypothalamus gonadotrophin-releasing hormone neuron fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818458", "aliases": ["hypothalamus gonadotropin-releasing hormone neuron development"], "types": ["T043"], "canonical_name": "hypothalamus gonadotrophin-releasing hormone neuron development", "definition": "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818459", "aliases": [], "types": ["T043"], "canonical_name": "olfactory bulb interneuron differentiation", "definition": "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818460", "aliases": [], "types": ["T043"], "canonical_name": "olfactory bulb interneuron fate commitment", "definition": "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818461", "aliases": [], "types": ["T043"], "canonical_name": "olfactory bulb interneuron development", "definition": "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818462", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex GABAergic interneuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818463", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex GABAergic interneuron fate commitment", "definition": "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818464", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex GABAergic interneuron development", "definition": "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818465", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818466", "aliases": [], "types": ["T043"], "canonical_name": "forebrain astrocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818467", "aliases": [], "types": ["T043"], "canonical_name": "forebrain astrocyte development", "definition": "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818468", "aliases": [], "types": ["T043"], "canonical_name": "commitment of multipotent stem cells to neuronal lineage in forebrain", "definition": "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C1818469", "aliases": ["fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818470", "aliases": [], "types": ["T043"], "canonical_name": "ventricular zone cell fate commitment", "definition": "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818471", "aliases": [], "types": ["T043"], "canonical_name": "early neuron fate commitment in forebrain", "definition": "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818472", "aliases": [], "types": ["T043"], "canonical_name": "commitment of neuronal cell to specific neuron type in forebrain", "definition": "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]"}
{"concept_id": "C1818473", "aliases": [], "types": ["T040"], "canonical_name": "rostrocaudal neural tube patterning", "definition": "The process in which the neural tube is divided into specific regions along the rostrocaudal axis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818474", "aliases": [], "types": ["T040"], "canonical_name": "anterior-posterior neural tube patterning"}
{"concept_id": "C1818475", "aliases": [], "types": ["T042"], "canonical_name": "neocortex development"}
{"concept_id": "C1818476", "aliases": ["dorsoventral neural tube patterning", "dorsal-ventral neural tube patterning"], "types": ["T042"], "canonical_name": "dorsal/ventral neural tube patterning", "definition": "The process in which the neural tube is regionalized in the dorsoventral axis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818477", "aliases": [], "types": ["T042"], "canonical_name": "forebrain-midbrain boundary formation", "definition": "The process whose specific outcome is the creation of the forebrain-midbrain boundary. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818478", "aliases": [], "types": ["T040"], "canonical_name": "hindbrain-spinal cord boundary formation", "definition": "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818479", "aliases": ["fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818480", "aliases": ["retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning"], "types": ["T044"], "canonical_name": "retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation", "definition": "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818482", "aliases": ["smoothened signalling pathway in ventral spinal cord patterning", "hh signaling pathway involved in ventral spinal cord patterning", "hedgehog signaling pathway involved in ventral spinal cord patterning"], "types": ["T044"], "canonical_name": "smoothened signaling pathway involved in ventral spinal cord patterning", "definition": "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:11262869]"}
{"concept_id": "C1818483", "aliases": ["retinoic acid metabolism in spinal cord anterior-posterior patterning"], "types": ["T044"], "canonical_name": "retinoic acid metabolic process in spinal cord anterior-posterior patterning", "definition": "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818487", "aliases": [], "types": ["T042"], "canonical_name": "neural tube development", "definition": "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818488", "aliases": ["inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors"], "types": ["T043"], "canonical_name": "inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors", "definition": "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]"}
{"concept_id": "C1818489", "aliases": [], "types": ["T043"], "canonical_name": "somatic motor neuron fate commitment", "definition": "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818491", "aliases": ["BMP signalling pathway involved in spinal cord dorsal-ventral patterning", "bone morphogenetic protein signalling pathway involved in spinal cord dorsal-ventral patterning", "bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning", "BMP signaling pathway in spinal cord dorsoventral patterning", "BMP signaling pathway involved in spinal cord dorsal-ventral patterning"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in spinal cord dorsal/ventral patterning", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981]"}
{"concept_id": "C1818493", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cell proliferation in dorsal spinal cord", "definition": "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818494", "aliases": ["Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord", "Wnt-activated signaling pathway involved in regulation of cell proliferation in dorsal spinal cord", "Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord", "definition": "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981]"}
{"concept_id": "C1818495", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation in hindbrain ventricular zone", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981, PMID:15157725]"}
{"concept_id": "C1818496", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation in external granule layer", "definition": "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818497", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar Purkinje cell precursor proliferation", "definition": "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818498", "aliases": [], "types": ["T043"], "canonical_name": "Golgi cell precursor proliferation", "definition": "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818499", "aliases": [], "types": ["T043"], "canonical_name": "deep nuclear neuron precursor proliferation", "definition": "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818500", "aliases": [], "types": ["T043"], "canonical_name": "basket cell precursor proliferation", "definition": "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818501", "aliases": [], "types": ["T043"], "canonical_name": "stellate cell precursor proliferation", "definition": "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818502", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar granule cell precursor proliferation", "definition": "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818503", "aliases": [], "types": ["T043"], "canonical_name": "rostral hindbrain neuronal precursor cell proliferation", "definition": "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818504", "aliases": [], "types": ["T043"], "canonical_name": "hindbrain radial glia guided cell migration", "definition": "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818505", "aliases": [], "types": ["T043"], "canonical_name": "radial glia guided migration of cerebellar granule cell", "definition": "The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818506", "aliases": [], "types": ["T043"], "canonical_name": "hindbrain tangential cell migration", "definition": "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818507", "aliases": [], "types": ["T043"], "canonical_name": "hindbrain neurophilic migration"}
{"concept_id": "C1818508", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar granule cell precursor tangential migration", "definition": "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818509", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cerebellar granule cell precursor proliferation", "definition": "The process that modulates the frequency, rate or extent of granule cell precursor proliferation. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818510", "aliases": ["Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation"], "types": ["T043"], "canonical_name": "cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation", "definition": "The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818511", "aliases": ["hedgehog signaling pathway involved in regulation of granule cell precursor cell proliferation", "smoothened signalling pathway in regulation of granule cell precursor cell proliferation", "hh signaling pathway involved in regulation of granule cell precursor cell proliferation"], "types": ["T044"], "canonical_name": "smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation", "definition": "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:15157725]"}
{"concept_id": "C1818512", "aliases": ["extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation"], "types": ["T043"], "canonical_name": "extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation", "definition": "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818513", "aliases": ["up regulation of granule cell precursor proliferation", "up-regulation of granule cell precursor proliferation", "upregulation of granule cell precursor proliferation"], "types": ["T043"], "canonical_name": "positive regulation of cerebellar granule cell precursor proliferation", "definition": "The process that activates or increases the rate or extent of granule cell precursor proliferation. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818514", "aliases": ["down regulation of granule cell precursor proliferation", "down-regulation of granule cell precursor proliferation", "downregulation of granule cell precursor proliferation"], "types": ["T043"], "canonical_name": "negative regulation of cerebellar granule cell precursor proliferation", "definition": "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818515", "aliases": [], "types": ["T043"], "canonical_name": "radial glia guided migration of Purkinje cell", "definition": "The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818516", "aliases": [], "types": ["T043"], "canonical_name": "formation of radial glial scaffolds", "definition": "The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818517", "aliases": ["Bergmann fiber formation"], "types": ["T043"], "canonical_name": "Bergmann fiber biosynthesis"}
{"concept_id": "C1818518", "aliases": [], "types": ["T043"], "canonical_name": "neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration", "definition": "The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818519", "aliases": ["calcium-mediated up-regulation of granule cell migration", "calcium-mediated up regulation of granule cell migration", "calcium-mediated positive regulation of granule cell migration", "calcium-mediated upregulation of granule cell migration"], "types": ["T043"], "canonical_name": "positive regulation of cerebellar granule cell migration by calcium", "definition": "The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:15157725]"}
{"concept_id": "C1818520", "aliases": [], "types": ["T043"], "canonical_name": "deep nuclear neuron cell migration", "definition": "The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818521", "aliases": [], "types": ["T043"], "canonical_name": "outward migration of deep nuclear neurons", "definition": "The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818522", "aliases": [], "types": ["T043"], "canonical_name": "inward migration of deep nuclear neurons", "definition": "The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818523", "aliases": [], "types": ["T043"], "canonical_name": "brainstem precerebellar neuron precursor migration", "definition": "The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818524", "aliases": ["negative chemotaxis involved in precerebellar neuron migration"], "types": ["T043"], "canonical_name": "chemorepulsion involved in precerebellar neuron migration", "definition": "The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818525", "aliases": ["positive chemotaxis involved in precerebellar neuron migration"], "types": ["T043"], "canonical_name": "chemoattraction involved in precerebellar neuron migration", "definition": "The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]"}
{"concept_id": "C1818526", "aliases": [], "types": ["T042"], "canonical_name": "central nervous system projection neuron axonogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818527", "aliases": [], "types": ["T042"], "canonical_name": "central nervous system axon tract development"}
{"concept_id": "C1818528", "aliases": [], "types": ["T043"], "canonical_name": "central nervous system neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818529", "aliases": [], "types": ["T043"], "canonical_name": "central nervous system neuron development", "definition": "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818530", "aliases": [], "types": ["T042"], "canonical_name": "central nervous system neuron axonogenesis", "definition": "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818531", "aliases": [], "types": ["T042"], "canonical_name": "central nervous system interneuron axonogenesis", "definition": "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818532", "aliases": ["CST axonogenesis", "corticospinal tract axonogenesis"], "types": ["T042"], "canonical_name": "corticospinal tract morphogenesis", "definition": "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]"}
{"concept_id": "C1818533", "aliases": ["tract of Goll morphogenesis"], "types": ["T042"], "canonical_name": "gracilis tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12867698]"}
{"concept_id": "C1818534", "aliases": ["tract of Burdach morphogenesis"], "types": ["T042"], "canonical_name": "cuneatus tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12867698]"}
{"concept_id": "C1818535", "aliases": [], "types": ["T042"], "canonical_name": "anterior commissure morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818536", "aliases": [], "types": ["T042"], "canonical_name": "posterior commissure morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818537", "aliases": [], "types": ["T042"], "canonical_name": "vestibulospinal tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818538", "aliases": ["dorsolateral tract of Lissauer morphogenesis"], "types": ["T042"], "canonical_name": "spinothalamic tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818539", "aliases": [], "types": ["T042"], "canonical_name": "rubrospinal tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818540", "aliases": [], "types": ["T042"], "canonical_name": "spinal cord ventral commissure morphogenesis", "definition": "The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818541", "aliases": ["corticospinal neuron axon pathfinding"], "types": ["T043"], "canonical_name": "corticospinal neuron axon guidance", "definition": "The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]"}
{"concept_id": "C1818542", "aliases": ["corticospinal neuron axon pathfinding through the cerebral cortex"], "types": ["T043"], "canonical_name": "corticospinal neuron axon guidance through the cerebral cortex", "definition": "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]"}
{"concept_id": "C1818543", "aliases": ["corticospinal neuron axon pathfinding through the internal capsule"], "types": ["T043"], "canonical_name": "corticospinal neuron axon guidance through the internal capsule", "definition": "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]"}
{"concept_id": "C1818544", "aliases": ["corticospinal neuron axon pathfinding through the cerebral peduncle"], "types": ["T043"], "canonical_name": "corticospinal neuron axon guidance through the cerebral peduncle", "definition": "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]"}
{"concept_id": "C1818545", "aliases": ["corticospinal neuron axon pathfinding through the basilar pons"], "types": ["T043"], "canonical_name": "corticospinal neuron axon guidance through the basilar pons", "definition": "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]"}
{"concept_id": "C1818546", "aliases": ["corticospinal neuron axon pathfinding through the medullary pyramid"], "types": ["T043"], "canonical_name": "corticospinal neuron axon guidance through the medullary pyramid", "definition": "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]"}
{"concept_id": "C1818547", "aliases": ["corticospinal neuron axon pathfinding through spinal cord"], "types": ["T043"], "canonical_name": "corticospinal neuron axon guidance through spinal cord", "definition": "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]"}
{"concept_id": "C1818548", "aliases": [], "types": ["T043"], "canonical_name": "corticospinal neuron axon decussation", "definition": "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]"}
{"concept_id": "C1818549", "aliases": [], "types": ["T042"], "canonical_name": "trigeminothalamic tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]"}
{"concept_id": "C1818550", "aliases": [], "types": ["T042"], "canonical_name": "pons reticulospinal tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818551", "aliases": [], "types": ["T042"], "canonical_name": "medulla reticulospinal tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818552", "aliases": [], "types": ["T042"], "canonical_name": "tectospinal tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818553", "aliases": [], "types": ["T042"], "canonical_name": "telencephalon regionalization", "definition": "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators]"}
{"concept_id": "C1818554", "aliases": [], "types": ["T043"], "canonical_name": "hypothalamus cell differentiation", "definition": "The differentiation of cells that will contribute to the structure and function of the hypothalamus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators]"}
{"concept_id": "C1818555", "aliases": [], "types": ["T043"], "canonical_name": "subpallium cell migration", "definition": "The orderly movement of cells from one site to another in the subpallium. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818556", "aliases": [], "types": ["T043"], "canonical_name": "subpallium radially oriented migration", "definition": "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818557", "aliases": ["epiphysis development"], "types": ["T042"], "canonical_name": "pineal gland development", "definition": "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818558", "aliases": ["hypophysis development"], "types": ["T042"], "canonical_name": "pituitary gland development", "definition": "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818560", "aliases": ["adenophysis development", "anterior pituitary gland development", "anterior pituitary development"], "types": ["T042"], "canonical_name": "adenohypophysis development", "definition": "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818561", "aliases": ["posterior pituitary gland development", "neurophysis development", "posterior pituitary development"], "types": ["T043"], "canonical_name": "neurohypophysis development", "definition": "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818562", "aliases": [], "types": ["T042"], "canonical_name": "habenula development", "definition": "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:9780721601465]"}
{"concept_id": "C1818563", "aliases": [], "types": ["T042"], "canonical_name": "cerebral cortex development", "definition": "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818564", "aliases": [], "types": ["T042"], "canonical_name": "olfactory lobe development", "definition": "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818565", "aliases": [], "types": ["T042"], "canonical_name": "olfactory cortex development", "definition": "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818566", "aliases": [], "types": ["T040"], "canonical_name": "neural plate formation", "definition": "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878932437, ISBN:0878932585, PMID:15806586]"}
{"concept_id": "C1818567", "aliases": [], "types": ["T042"], "canonical_name": "neural plate thickening", "definition": "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]"}
{"concept_id": "C1818568", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in neural plate elongation", "definition": "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586]"}
{"concept_id": "C1818569", "aliases": [], "types": ["T040"], "canonical_name": "initiation of neural tube closure", "definition": "The process in which closure points are established at multiple points and along the neural rostrocaudal axis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818570", "aliases": [], "types": ["T040"], "canonical_name": "progression of neural tube closure", "definition": "The process in which the neural folds are fused extending from the initial closure points. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818571", "aliases": [], "types": ["T040"], "canonical_name": "neuropore closure", "definition": "The process of joining together the neural folds at either end of the neural tube. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818572", "aliases": [], "types": ["T040"], "canonical_name": "lamina terminalis formation", "definition": "The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818574", "aliases": ["neural plate mediolateral pattern formation"], "types": ["T040"], "canonical_name": "neural plate mediolateral regionalization", "definition": "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818576", "aliases": [], "types": ["T043"], "canonical_name": "forebrain induction by the anterior neural ridge", "definition": "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818577", "aliases": ["down regulation of anterior neural cell fate of the neural plate", "negative regulation of anterior neural cell fate of the neural plate", "caudalization of neural plate", "down-regulation of anterior neural cell fate of the neural plate", "downregulation of anterior neural cell fate of the neural plate"], "types": ["T038"], "canonical_name": "negative regulation of anterior neural cell fate commitment of the neural plate", "definition": "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1818578", "aliases": [], "types": ["T038"], "canonical_name": "posteriorization"}
{"concept_id": "C1818579", "aliases": ["negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway", "Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate", "Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate", "Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate", "Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate", "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt-activated signaling pathway", "Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate"], "types": ["T038"], "canonical_name": "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway", "definition": "The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1818580", "aliases": ["fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate", "fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate", "fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate", "fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate", "fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate"], "types": ["T038"], "canonical_name": "negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway", "definition": "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1818581", "aliases": [], "types": ["T042"], "canonical_name": "midbrain-hindbrain boundary maturation during brain development", "definition": "A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]"}
{"concept_id": "C1818582", "aliases": [], "types": ["T042"], "canonical_name": "midbrain-hindbrain boundary maturation during neural plate development", "definition": "A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]"}
{"concept_id": "C1818583", "aliases": ["zli formation", "zli biosynthesis"], "types": ["T040"], "canonical_name": "zona limitans intrathalamica formation", "definition": "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11425897, PMID:16452095]"}
{"concept_id": "C1818584", "aliases": [], "types": ["T043"], "canonical_name": "convergent extension involved in neural plate elongation", "definition": "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586]"}
{"concept_id": "C1818585", "aliases": [], "types": ["T042"], "canonical_name": "central nervous system vasculogenesis", "definition": "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818586", "aliases": ["myelination in central nervous system"], "types": ["T043"], "canonical_name": "central nervous system myelination", "definition": "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818587", "aliases": ["peripheral nervous system myelination"], "types": ["T043"], "canonical_name": "myelination in peripheral nervous system", "definition": "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818588", "aliases": [], "types": ["T043"], "canonical_name": "subpallium cell proliferation in forebrain", "definition": "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818589", "aliases": [], "types": ["T043"], "canonical_name": "pallium cell proliferation in forebrain", "definition": "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818591", "aliases": [], "types": ["T043"], "canonical_name": "radial glial cell division in pallium", "definition": "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818592", "aliases": ["glioblast cell division in pallium"], "types": ["T043"], "canonical_name": "pallium glioblast division", "definition": "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818593", "aliases": [], "types": ["T043"], "canonical_name": "neuroblast division in pallium", "definition": "The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818594", "aliases": [], "types": ["T043"], "canonical_name": "lateral ganglionic eminence cell proliferation", "definition": "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818595", "aliases": [], "types": ["T043"], "canonical_name": "dorsal lateral ganglionic eminence cell proliferation", "definition": "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818596", "aliases": [], "types": ["T043"], "canonical_name": "medial ganglionic eminence cell proliferation", "definition": "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818597", "aliases": [], "types": ["T043"], "canonical_name": "caudal ganglionic eminence cell proliferation", "definition": "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818598", "aliases": ["septum cell proliferation"], "types": ["T043"], "canonical_name": "septal cell proliferation", "definition": "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818599", "aliases": [], "types": ["T043"], "canonical_name": "radial glial cell fate commitment in forebrain", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818600", "aliases": ["bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment", "bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment", "BMP signalling pathway involved in forebrain neuron fate commitment"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in forebrain neuron fate commitment", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818601", "aliases": ["leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment"], "types": ["T044"], "canonical_name": "leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment", "definition": "The series of molecular signals initiated by the binding of leukemia inhibitory factor to its receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:signaling]"}
{"concept_id": "C1818602", "aliases": ["epidermal growth factor signalling pathway involved in forebrain neuron fate commitment"], "types": ["T044"], "canonical_name": "epidermal growth factor signaling pathway involved in forebrain neuron fate commitment", "definition": "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818603", "aliases": [], "types": ["T038"], "canonical_name": "interkinetic nuclear migration", "definition": "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818604", "aliases": ["rostral migratory stream migration"], "types": ["T043"], "canonical_name": "tangential migration from the subventricular zone to the olfactory bulb", "definition": "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818605", "aliases": [], "types": ["T043"], "canonical_name": "telencephalon cell migration", "definition": "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818606", "aliases": [], "types": ["T043"], "canonical_name": "telencephalon glial cell migration", "definition": "The orderly movement of glial cells through the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818607", "aliases": [], "types": ["T043"], "canonical_name": "telencephalon astrocyte cell migration", "definition": "The orderly movement of an astrocyte cell through the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818608", "aliases": [], "types": ["T043"], "canonical_name": "telencephalon oligodendrocyte cell migration", "definition": "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818609", "aliases": [], "types": ["T043"], "canonical_name": "telencephalon microglial cell migration", "definition": "The orderly movement of microglial cells through the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818610", "aliases": [], "types": ["T043"], "canonical_name": "rhombomere cell proliferation", "definition": "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818611", "aliases": [], "types": ["T043"], "canonical_name": "rhombomere cell migration", "definition": "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15629700]"}
{"concept_id": "C1818612", "aliases": [], "types": ["T043"], "canonical_name": "rhombomere cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818613", "aliases": [], "types": ["T042"], "canonical_name": "metencephalon development", "definition": "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818614", "aliases": [], "types": ["T042"], "canonical_name": "corpus callosum development", "definition": "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1818615", "aliases": ["regulation of rhodopsin mediated signalling"], "types": ["T043"], "canonical_name": "regulation of rhodopsin mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. [GOC:mah]"}
{"concept_id": "C1818617", "aliases": [], "types": ["T043"], "definition": "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. [GOC:isa_complete, GOC:mtg_cell_cycle]", "canonical_name": "cell cycle process"}
{"concept_id": "C1818619", "aliases": [], "types": ["T040"], "canonical_name": "molting cycle process", "definition": "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin. [GOC:isa_complete]"}
{"concept_id": "C1818620", "aliases": [], "types": ["T040"], "canonical_name": "hair cycle process", "definition": "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. [GOC:isa_complete]"}
{"concept_id": "C1818621", "aliases": [], "types": ["T043"], "canonical_name": "membrane docking", "definition": "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. [GOC:isa_complete, PMID:27875684]"}
{"concept_id": "C1818622", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell-cell adhesion", "definition": "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. [GOC:isa_complete]"}
{"concept_id": "C1818624", "aliases": ["up regulation of cell-cell adhesion", "up-regulation of cell-cell adhesion", "upregulation of cell-cell adhesion"], "types": ["T043"], "canonical_name": "positive regulation of cell-cell adhesion", "definition": "Any process that activates or increases the rate or extent of cell adhesion to another cell. [GOC:isa_complete]"}
{"concept_id": "C1818625", "aliases": [], "types": ["T040"], "canonical_name": "circadian sleep/wake cycle process", "definition": "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. [GOC:isa_complete]"}
{"concept_id": "C1818627", "aliases": ["reproductive cellular process in multicellular organism"], "types": ["T043"], "canonical_name": "cellular process involved in reproduction in multicellular organism", "definition": "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. [GOC:isa_complete]"}
{"concept_id": "C1818628", "aliases": [], "types": ["T043"], "canonical_name": "reproductive process in single-celled organism", "definition": "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism. [GOC:isa_complete]"}
{"concept_id": "C1818630", "aliases": [], "types": ["T042"], "canonical_name": "bristle development"}
{"concept_id": "C1818631", "aliases": [], "types": ["T044"], "canonical_name": "protein maturation by protein folding", "definition": "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein. [GOC:isa_complete]"}
{"concept_id": "C1818633", "aliases": [], "types": ["T039"], "definition": "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur. [GOC:dph, GOC:isa_complete, GOC:jid]", "canonical_name": "menstrual cycle phase"}
{"concept_id": "C1818634", "aliases": [], "types": ["T040"], "canonical_name": "menstrual cycle process"}
{"concept_id": "C1818635", "aliases": ["regulation of morphogenesis"], "types": ["T038"], "canonical_name": "regulation of anatomical structure morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. [GOC:mah]"}
{"concept_id": "C1818636", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cell morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. [GOC:isa_complete]"}
{"concept_id": "C1818637", "aliases": ["mammalian oogenesis process"], "types": ["T039"], "canonical_name": "mammalian oogenesis stage", "definition": "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell. [GOC:isa_complete, GOC:mtg_sensu]"}
{"concept_id": "C1818638", "aliases": [], "types": ["T043"], "canonical_name": "establishment of proximal/distal cell polarity", "definition": "The specification and formation of the polarity of a cell along its proximal/distal axis. [GOC:isa_complete]"}
{"concept_id": "C1818640", "aliases": [], "types": ["T038"], "canonical_name": "multicellular organism adhesion", "definition": "The attachment of a multicellular organism to a substrate or other organism. [GOC:isa_complete]"}
{"concept_id": "C1818641", "aliases": [], "types": ["T038"], "canonical_name": "multicellular organism adhesion to substrate", "definition": "The attachment of a multicellular organism to a surface or material. [GOC:isa_complete]"}
{"concept_id": "C1818643", "aliases": [], "types": ["T042"], "canonical_name": "dormancy process", "definition": "A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated. [GOC:isa_complete, GOC:PO_curators, PO_REF:00009]"}
{"concept_id": "C1818644", "aliases": [], "types": ["T040"], "canonical_name": "gland morphogenesis", "definition": "The process in which the anatomical structures of a gland are generated and organized. [GOC:isa_complete]"}
{"concept_id": "C1818645", "aliases": ["ribonucleoprotein complex biogenesis and assembly", "RNA-protein complex biogenesis"], "types": ["T043"], "canonical_name": "ribonucleoprotein complex biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. [GOC:isa_complete, GOC:mah]"}
{"concept_id": "C1818646", "aliases": ["membrane-membrane docking"], "types": ["T043"], "canonical_name": "membrane to membrane docking", "definition": "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere. [GOC:isa_complete]"}
{"concept_id": "C1818647", "aliases": ["protein-membrane docking"], "types": ["T043"], "canonical_name": "protein to membrane docking", "definition": "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere. [GOC:isa_complete]"}
{"concept_id": "C1818648", "aliases": [], "types": ["T045"], "canonical_name": "DNA strand elongation", "definition": "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. [GOC:isa_complete, GOC:mah]"}
{"concept_id": "C1818649", "aliases": [], "types": ["T043"], "canonical_name": "extracellular matrix disassembly", "definition": "A process that results in the breakdown of the extracellular matrix. [GOC:jid]"}
{"concept_id": "C1818650", "aliases": ["RNA-protein complex assembly", "protein-RNA complex assembly", "RNP complex assembly"], "types": ["T045"], "canonical_name": "ribonucleoprotein complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. [GOC:jl]"}
{"concept_id": "C1818651", "aliases": [], "types": ["T043"], "canonical_name": "generative cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte. [GOC:isa_complete]"}
{"concept_id": "C1818654", "aliases": [], "types": ["T042"], "canonical_name": "root system development", "definition": "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure. [GOC:isa_complete]"}
{"concept_id": "C1818655", "aliases": [], "types": ["T044"], "canonical_name": "GKAP/Homer scaffold activity"}
{"concept_id": "C1818657", "aliases": ["ABC translocator complex location"], "types": ["T026"], "canonical_name": "ABC translocator complex"}
{"concept_id": "C1818658", "aliases": ["nucleus fragmentation", "apoptotic nuclear fragmentation"], "types": ["T043"], "canonical_name": "nuclear fragmentation involved in apoptotic nuclear change", "definition": "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976]"}
{"concept_id": "C1818659", "aliases": ["male genital development"], "types": ["T038"], "canonical_name": "male genitalia development", "definition": "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. [GOC:ems, ISBN:0140512888]"}
{"concept_id": "C1818660", "aliases": ["female genital development"], "types": ["T038"], "canonical_name": "female genitalia development", "definition": "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. [GOC:mah]"}
{"concept_id": "C1818661", "aliases": ["dimeric RNase P complex", "dimeric RNase P complex location", "dimeric ribonuclease P complex location"], "types": ["T026"], "canonical_name": "dimeric ribonuclease P complex", "definition": "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species. [GOC:mah, PMID:12045094]"}
{"concept_id": "C1818662", "aliases": ["multimeric RNase P complex location", "multimeric RNase P complex", "multimeric ribonuclease P complex location"], "types": ["T026"], "canonical_name": "multimeric ribonuclease P complex", "definition": "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species. [GOC:mah, PMID:11142368, PMID:12045094]"}
{"concept_id": "C1818663", "aliases": ["medial ring"], "types": ["T026"], "canonical_name": "medial cortex", "definition": "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation. [GOC:vw, PMID:15572668, PMID:19474789]"}
{"concept_id": "C1818664", "aliases": ["aggregation during fruiting body development", "aggregate development involved in sorocarp development"], "types": ["T040"], "canonical_name": "aggregation involved in sorocarp development", "definition": "The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]"}
{"concept_id": "C1818665", "aliases": ["culminant development", "culmination during fruiting body development"], "types": ["T040"], "canonical_name": "culmination involved in sorocarp development", "definition": "The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development. [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]"}
{"concept_id": "C1818666", "aliases": [], "types": ["T040"], "canonical_name": "regulation of aggregation during fruiting body biosynthesis"}
{"concept_id": "C1818667", "aliases": ["neuron projection development"], "types": ["T043"], "definition": "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:mah]", "canonical_name": "neurite development"}
{"concept_id": "C1818668", "aliases": ["exo-1,4-beta-glucanase activity", "glucan endo-1,4-beta-glucosidase activity", "endo-1,4-beta-glucanase activity", "exocellulase activity", "exo-beta-1,4-glucosidase activity", "beta-1->4-glucan hydrolase activity", "endo-(1,4)-beta-D-glucanase activity", "exo-1,4-beta-glucosidase activity", "endo-1,4-beta-D-glucanase activity", "endo-(1->4)-beta-D-glucanase activity", "beta-1,4-glucan hydrolase activity", "beta-1,4-glucan 4-glucanohydrolase activity", "beta-1,4-glucanase activity", "endo-beta-1,4-glucanase activity", "exo-beta-1,4-glucanase activity", "1,4-beta-D-glucan glucanohydrolase activity", "exo-1,4-beta-D-glucosidase activity"], "types": ["T044"], "canonical_name": "glucan 1,4-beta-glucosidase activity", "definition": "Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units. [EC:3.2.1.74, GOC:mlg]"}
{"concept_id": "C1818669", "aliases": ["membrane projection"], "types": ["T026"], "canonical_name": "membrane extension"}
{"concept_id": "C1818671", "aliases": [], "types": ["T044"], "canonical_name": "glutamine amidotransferase:cyclase activity"}
{"concept_id": "C1818672", "aliases": [], "types": ["T046"], "canonical_name": "type I hypersensitivity mediated by mast cells", "definition": "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818673", "aliases": [], "types": ["T046"], "canonical_name": "type I hypersensitivity mediated by basophils", "definition": "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818674", "aliases": [], "types": ["T038"], "canonical_name": "basophil mediated immunity", "definition": "Any process involved in the carrying out of an immune response by a basophil. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818675", "aliases": [], "types": ["T043"], "canonical_name": "basophil degranulation", "definition": "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818676", "aliases": [], "types": ["T045"], "canonical_name": "somatic diversification of immune receptors via germline recombination within a single locus", "definition": "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]"}
{"concept_id": "C1818677", "aliases": [], "types": ["T045"], "canonical_name": "somatic diversification of immune receptors via alternate splicing", "definition": "The process in which immune receptor genes are diversified through alternate splicing. [GOC:add, ISBN:0781735149, PMID:16166509]"}
{"concept_id": "C1818678", "aliases": ["alternate splicing of antibody genes"], "types": ["T045"], "canonical_name": "alternate splicing of immunoglobulin genes", "definition": "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons. [ISBN:0781735149, PMID:9185563]"}
{"concept_id": "C1818679", "aliases": [], "types": ["T045"], "canonical_name": "somatic diversification of immune receptors via gene conversion", "definition": "The process in which immune receptor genes are diversified through gene conversion. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818680", "aliases": [], "types": ["T038"], "canonical_name": "somatic diversification of immune receptors via somatic mutation", "definition": "The process in which immune receptor genes are diversified through somatic mutation. [ISBN:0781735149, PMID:16102575]"}
{"concept_id": "C1818681", "aliases": [], "types": ["T038"], "canonical_name": "somatic diversification of FREP-based immune receptors", "definition": "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails. [GOC:add, PMID:16102575]"}
{"concept_id": "C1818682", "aliases": ["somatic diversification of TCR genes"], "types": ["T038"], "canonical_name": "somatic diversification of T cell receptor genes", "definition": "The somatic process that results in the generation of sequence diversity of T cell receptor genes. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818683", "aliases": [], "types": ["T038"], "canonical_name": "somatic diversification of immune receptors by N region addition", "definition": "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818684", "aliases": ["somatic diversification of antibody genes by N region addition"], "types": ["T038"], "canonical_name": "somatic diversification of immunoglobulin genes by N region addition", "definition": "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818685", "aliases": ["somatic diversification of TCR genes by N region addition"], "types": ["T038"], "canonical_name": "somatic diversification of T cell receptor genes by N region addition", "definition": "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818686", "aliases": ["pro-T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "pro-T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818687", "aliases": ["myeloid leucocyte differentiation"], "types": ["T043"], "canonical_name": "myeloid leukocyte differentiation", "definition": "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. [GOC:add, PMID:16551251]"}
{"concept_id": "C1818689", "aliases": [], "types": ["T043"], "canonical_name": "basophil chemotaxis", "definition": "The movement of a basophil in response to an external stimulus. [GOC:add, PMID:11292027]"}
{"concept_id": "C1818690", "aliases": ["platelet exocytosis"], "types": ["T044"], "canonical_name": "platelet degranulation", "definition": "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. [GOC:add]"}
{"concept_id": "C1818691", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818692", "aliases": ["down-regulation of antigen processing and presentation", "downregulation of antigen processing and presentation", "down regulation of antigen processing and presentation"], "types": ["T039"], "canonical_name": "negative regulation of antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818693", "aliases": ["up regulation of antigen processing and presentation", "up-regulation of antigen processing and presentation", "upregulation of antigen processing and presentation"], "types": ["T039"], "canonical_name": "positive regulation of antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818694", "aliases": ["regulation of peptide or polysaccharide antigen processing and presentation via MHC class II"], "types": ["T038"], "canonical_name": "regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "definition": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. [GOC:add]"}
{"concept_id": "C1818695", "aliases": ["negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II", "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"], "types": ["T039"], "canonical_name": "negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. [GOC:add]"}
{"concept_id": "C1818696", "aliases": ["up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II", "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"], "types": ["T039"], "canonical_name": "positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "definition": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. [GOC:add]"}
{"concept_id": "C1818697", "aliases": ["regulation of peptide antigen processing and presentation"], "types": ["T038"], "canonical_name": "regulation of antigen processing and presentation of peptide antigen", "definition": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. [GOC:add]"}
{"concept_id": "C1818698", "aliases": ["down regulation of antigen processing and presentation of peptide antigen", "down-regulation of antigen processing and presentation of peptide antigen", "negative regulation of peptide antigen processing and presentation", "downregulation of antigen processing and presentation of peptide antigen"], "types": ["T039"], "canonical_name": "negative regulation of antigen processing and presentation of peptide antigen", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen. [GOC:add]"}
{"concept_id": "C1818699", "aliases": ["positive regulation of peptide antigen processing and presentation", "up-regulation of antigen processing and presentation of peptide antigen", "upregulation of antigen processing and presentation of peptide antigen", "up regulation of antigen processing and presentation of peptide antigen"], "types": ["T039"], "canonical_name": "positive regulation of antigen processing and presentation of peptide antigen", "definition": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen. [GOC:add]"}
{"concept_id": "C1818700", "aliases": ["regulation of peptide antigen processing and presentation via MHC class II"], "types": ["T038"], "canonical_name": "regulation of antigen processing and presentation of peptide antigen via MHC class II", "definition": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. [GOC:add]"}
{"concept_id": "C1818701", "aliases": ["negative regulation of peptide antigen processing and presentation via MHC class II", "down regulation of antigen processing and presentation of peptide antigen via MHC class II", "down-regulation of antigen processing and presentation of peptide antigen via MHC class II", "downregulation of antigen processing and presentation of peptide antigen via MHC class II"], "types": ["T039"], "canonical_name": "negative regulation of antigen processing and presentation of peptide antigen via MHC class II", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. [GOC:add]"}
{"concept_id": "C1818702", "aliases": ["positive regulation of peptide antigen processing and presentation via MHC class II", "upregulation of antigen processing and presentation of peptide antigen via MHC class II", "up regulation of antigen processing and presentation of peptide antigen via MHC class II", "up-regulation of antigen processing and presentation of peptide antigen via MHC class II"], "types": ["T039"], "canonical_name": "positive regulation of antigen processing and presentation of peptide antigen via MHC class II", "definition": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. [GOC:add]"}
{"concept_id": "C1818703", "aliases": ["regulation of peptide antigen processing and presentation via MHC class I"], "types": ["T038"], "canonical_name": "regulation of antigen processing and presentation of peptide antigen via MHC class I", "definition": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. [GOC:add]"}
{"concept_id": "C1818704", "aliases": ["downregulation of antigen processing and presentation of peptide antigen via MHC class I", "negative regulation of peptide antigen processing and presentation via MHC class I", "down regulation of antigen processing and presentation of peptide antigen via MHC class I", "down-regulation of antigen processing and presentation of peptide antigen via MHC class I"], "types": ["T039"], "canonical_name": "negative regulation of antigen processing and presentation of peptide antigen via MHC class I", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. [GOC:add]"}
{"concept_id": "C1818705", "aliases": ["upregulation of antigen processing and presentation of peptide antigen via MHC class I", "positive regulation of peptide antigen processing and presentation via MHC class I", "up-regulation of antigen processing and presentation of peptide antigen via MHC class I", "up regulation of antigen processing and presentation of peptide antigen via MHC class I"], "types": ["T039"], "canonical_name": "positive regulation of antigen processing and presentation of peptide antigen via MHC class I", "definition": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. [GOC:add]"}
{"concept_id": "C1818706", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antigen processing and presentation via MHC class Ib", "definition": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. [GOC:add]"}
{"concept_id": "C1818707", "aliases": ["down-regulation of antigen processing and presentation via MHC class Ib", "downregulation of antigen processing and presentation via MHC class Ib", "down regulation of antigen processing and presentation via MHC class Ib"], "types": ["T039"], "canonical_name": "negative regulation of antigen processing and presentation via MHC class Ib", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. [GOC:add]"}
{"concept_id": "C1818708", "aliases": ["upregulation of antigen processing and presentation via MHC class Ib", "up-regulation of antigen processing and presentation via MHC class Ib", "up regulation of antigen processing and presentation via MHC class Ib"], "types": ["T039"], "canonical_name": "positive regulation of antigen processing and presentation via MHC class Ib", "definition": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. [GOC:add]"}
{"concept_id": "C1818709", "aliases": ["regulation of peptide antigen processing and presentation via MHC class Ib"], "types": ["T038"], "canonical_name": "regulation of antigen processing and presentation of peptide antigen via MHC class Ib", "definition": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. [GOC:add]"}
{"concept_id": "C1818710", "aliases": ["downregulation of antigen processing and presentation of peptide antigen via MHC class Ib", "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib", "negative regulation of peptide antigen processing and presentation via MHC class Ib", "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib"], "types": ["T039"], "canonical_name": "negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. [GOC:add]"}
{"concept_id": "C1818711", "aliases": ["up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib", "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib", "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib", "positive regulation of peptide antigen processing and presentation via MHC class Ib"], "types": ["T039"], "canonical_name": "positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib", "definition": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. [GOC:add]"}
{"concept_id": "C1818712", "aliases": ["regulation of lipid antigen processing and presentation via MHC class Ib"], "types": ["T038"], "canonical_name": "regulation of antigen processing and presentation of lipid antigen via MHC class Ib", "definition": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. [GOC:add]"}
{"concept_id": "C1818713", "aliases": ["downregulation of antigen processing and presentation of lipid antigen via MHC class Ib", "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib", "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib", "negative regulation of lipid antigen processing and presentation via MHC class Ib"], "types": ["T039"], "canonical_name": "negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. [GOC:add]"}
{"concept_id": "C1818714", "aliases": ["upregulation of antigen processing and presentation of lipid antigen via MHC class Ib", "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib", "positive regulation of lipid antigen processing and presentation via MHC class Ib", "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib"], "types": ["T039"], "canonical_name": "positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib", "definition": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. [GOC:add]"}
{"concept_id": "C1818715", "aliases": ["regulation of polysaccharide antigen processing and presentation via MHC class II"], "types": ["T038"], "canonical_name": "regulation of antigen processing and presentation of polysaccharide antigen via MHC class II", "definition": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. [GOC:add]"}
{"concept_id": "C1818716", "aliases": ["down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II", "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II", "negative regulation of polysaccharide antigen processing and presentation via MHC class II", "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II"], "types": ["T039"], "canonical_name": "negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. [GOC:add]"}
{"concept_id": "C1818717", "aliases": ["positive regulation of polysaccharide antigen processing and presentation via MHC class II", "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II", "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II", "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II"], "types": ["T039"], "canonical_name": "positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II", "definition": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. [GOC:add]"}
{"concept_id": "C1818718", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendritic cell antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818719", "aliases": ["downregulation of dendritic cell antigen processing and presentation", "down-regulation of dendritic cell antigen processing and presentation", "down regulation of dendritic cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "negative regulation of dendritic cell antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818720", "aliases": ["up regulation of dendritic cell antigen processing and presentation", "up-regulation of dendritic cell antigen processing and presentation", "upregulation of dendritic cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "positive regulation of dendritic cell antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818721", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myeloid dendritic cell antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818722", "aliases": ["down-regulation of myeloid dendritic cell antigen processing and presentation", "downregulation of myeloid dendritic cell antigen processing and presentation", "down regulation of myeloid dendritic cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "negative regulation of myeloid dendritic cell antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818723", "aliases": ["upregulation of myeloid dendritic cell antigen processing and presentation", "up regulation of myeloid dendritic cell antigen processing and presentation", "up-regulation of myeloid dendritic cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "positive regulation of myeloid dendritic cell antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818724", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plasmacytoid dendritic cell antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818725", "aliases": ["down-regulation of plasmacytoid dendritic cell antigen processing and presentation", "downregulation of plasmacytoid dendritic cell antigen processing and presentation", "down regulation of plasmacytoid dendritic cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "negative regulation of plasmacytoid dendritic cell antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818726", "aliases": ["up-regulation of plasmacytoid dendritic cell antigen processing and presentation", "upregulation of plasmacytoid dendritic cell antigen processing and presentation", "up regulation of plasmacytoid dendritic cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "positive regulation of plasmacytoid dendritic cell antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818727", "aliases": [], "types": ["T043"], "canonical_name": "regulation of monocyte antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818728", "aliases": ["down-regulation of monocyte antigen processing and presentation", "downregulation of monocyte antigen processing and presentation", "down regulation of monocyte antigen processing and presentation"], "types": ["T043"], "canonical_name": "negative regulation of monocyte antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818729", "aliases": ["up-regulation of monocyte antigen processing and presentation", "up regulation of monocyte antigen processing and presentation", "upregulation of monocyte antigen processing and presentation"], "types": ["T043"], "canonical_name": "positive regulation of monocyte antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818730", "aliases": [], "types": ["T043"], "canonical_name": "regulation of macrophage antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818731", "aliases": ["down regulation of macrophage antigen processing and presentation", "down-regulation of macrophage antigen processing and presentation", "downregulation of macrophage antigen processing and presentation"], "types": ["T043"], "canonical_name": "negative regulation of macrophage antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818732", "aliases": ["up regulation of macrophage antigen processing and presentation", "up-regulation of macrophage antigen processing and presentation", "upregulation of macrophage antigen processing and presentation"], "types": ["T043"], "canonical_name": "positive regulation of macrophage antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818733", "aliases": [], "types": ["T043"], "canonical_name": "regulation of non-professional antigen presenting cell antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818734", "aliases": ["down regulation of non-professional antigen presenting cell antigen processing and presentation", "down-regulation of non-professional antigen presenting cell antigen processing and presentation", "downregulation of non-professional antigen presenting cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "negative regulation of non-professional antigen presenting cell antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818735", "aliases": ["up-regulation of non-professional antigen presenting cell antigen processing and presentation", "up regulation of non-professional antigen presenting cell antigen processing and presentation", "upregulation of non-professional antigen presenting cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "positive regulation of non-professional antigen presenting cell antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818736", "aliases": ["regulation of B lymphocyte antigen processing and presentation", "regulation of B-cell antigen processing and presentation", "regulation of B-lymphocyte antigen processing and presentation"], "types": ["T043"], "canonical_name": "regulation of B cell antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818737", "aliases": ["negative regulation of B lymphocyte antigen processing and presentation", "down-regulation of B cell antigen processing and presentation", "down regulation of B cell antigen processing and presentation", "downregulation of B cell antigen processing and presentation", "negative regulation of B-cell antigen processing and presentation", "negative regulation of B-lymphocyte antigen processing and presentation"], "types": ["T043"], "canonical_name": "negative regulation of B cell antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818738", "aliases": ["positive regulation of B lymphocyte antigen processing and presentation", "upregulation of B cell antigen processing and presentation", "up-regulation of B cell antigen processing and presentation", "positive regulation of B-cell antigen processing and presentation", "positive regulation of B-lymphocyte antigen processing and presentation", "up regulation of B cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "positive regulation of B cell antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818739", "aliases": ["regulation of T-lymphocyte antigen processing and presentation", "regulation of T lymphocyte antigen processing and presentation", "regulation of T-cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "regulation of T cell antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818740", "aliases": ["negative regulation of T lymphocyte antigen processing and presentation", "down regulation of T cell antigen processing and presentation", "down-regulation of T cell antigen processing and presentation", "negative regulation of T-cell antigen processing and presentation", "negative regulation of T-lymphocyte antigen processing and presentation", "downregulation of T cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "negative regulation of T cell antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818741", "aliases": ["up-regulation of T cell antigen processing and presentation", "up regulation of T cell antigen processing and presentation", "positive regulation of T lymphocyte antigen processing and presentation", "positive regulation of T-cell antigen processing and presentation", "positive regulation of T-lymphocyte antigen processing and presentation", "upregulation of T cell antigen processing and presentation"], "types": ["T043"], "canonical_name": "positive regulation of T cell antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818742", "aliases": [], "types": ["T038"], "canonical_name": "regulation of proteolysis associated with antigen processing and presentation", "definition": "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818743", "aliases": ["down-regulation of proteolysis associated with antigen processing and presentation", "downregulation of proteolysis associated with antigen processing and presentation", "down regulation of proteolysis associated with antigen processing and presentation"], "types": ["T039"], "canonical_name": "negative regulation of proteolysis associated with antigen processing and presentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818744", "aliases": ["up regulation of proteolysis associated with antigen processing and presentation", "upregulation of proteolysis associated with antigen processing and presentation", "up-regulation of proteolysis associated with antigen processing and presentation"], "types": ["T039"], "canonical_name": "positive regulation of proteolysis associated with antigen processing and presentation", "definition": "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. [GOC:add]"}
{"concept_id": "C1818745", "aliases": [], "types": ["T038"], "canonical_name": "regulation of granuloma formation", "definition": "Any process that modulates the frequency, rate, or extent of granuloma formation. [GOC:add]"}
{"concept_id": "C1818746", "aliases": ["down-regulation of granuloma formation", "down regulation of granuloma formation", "downregulation of granuloma formation"], "types": ["T039"], "canonical_name": "negative regulation of granuloma formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation. [GOC:add]"}
{"concept_id": "C1818747", "aliases": ["up-regulation of granuloma formation", "upregulation of granuloma formation", "up regulation of granuloma formation"], "types": ["T039"], "canonical_name": "positive regulation of granuloma formation", "definition": "Any process that activates or increases the frequency, rate, or extent of granuloma formation. [GOC:add]"}
{"concept_id": "C1818748", "aliases": [], "types": ["T040"], "canonical_name": "regulation of germinal center formation", "definition": "Any process that modulates the frequency, rate, or extent of germinal center formation. [GOC:add]"}
{"concept_id": "C1818749", "aliases": ["down regulation of germinal center formation", "downregulation of germinal center formation", "down-regulation of germinal center formation"], "types": ["T040"], "canonical_name": "negative regulation of germinal center formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation. [GOC:add]"}
{"concept_id": "C1818750", "aliases": ["up-regulation of germinal center formation", "upregulation of germinal center formation", "up regulation of germinal center formation"], "types": ["T040"], "canonical_name": "positive regulation of germinal center formation", "definition": "Any process that activates or increases the frequency, rate, or extent of germinal center formation. [GOC:add]"}
{"concept_id": "C1818751", "aliases": ["regulation of antibody production"], "types": ["T043"], "canonical_name": "regulation of immunoglobulin production", "definition": "Any process that modulates the frequency, rate, or extent of immunoglobulin production. [GOC:add]"}
{"concept_id": "C1818752", "aliases": ["downregulation of immunoglobulin production", "down regulation of immunoglobulin production", "down-regulation of immunoglobulin production"], "types": ["T040"], "canonical_name": "negative regulation of immunoglobulin production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. [GOC:add]"}
{"concept_id": "C1818753", "aliases": ["up regulation of immunoglobulin production", "upregulation of immunoglobulin production", "up-regulation of immunoglobulin production"], "types": ["T043"], "canonical_name": "positive regulation of immunoglobulin production", "definition": "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. [GOC:add]"}
{"concept_id": "C1818757", "aliases": [], "types": ["T038"], "canonical_name": "regulation of tolerance induction", "definition": "Any process that modulates the frequency, rate, or extent of tolerance induction. [GOC:add]"}
{"concept_id": "C1818758", "aliases": ["downregulation of tolerance induction", "down regulation of tolerance induction", "down-regulation of tolerance induction"], "types": ["T039"], "canonical_name": "negative regulation of tolerance induction", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction. [GOC:add]"}
{"concept_id": "C1818759", "aliases": ["upregulation of tolerance induction", "up regulation of tolerance induction", "up-regulation of tolerance induction"], "types": ["T039"], "canonical_name": "positive regulation of tolerance induction", "definition": "Any process that activates or increases the frequency, rate, or extent of tolerance induction. [GOC:add]"}
{"concept_id": "C1818760", "aliases": [], "types": ["T038"], "canonical_name": "regulation of central tolerance induction", "definition": "Any process that modulates the frequency, rate, or extent of central tolerance induction. [GOC:add]"}
{"concept_id": "C1818761", "aliases": ["down regulation of central tolerance induction", "downregulation of central tolerance induction", "down-regulation of central tolerance induction"], "types": ["T039"], "canonical_name": "negative regulation of central tolerance induction", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction. [GOC:add]"}
{"concept_id": "C1818762", "aliases": ["upregulation of central tolerance induction", "up regulation of central tolerance induction", "up-regulation of central tolerance induction"], "types": ["T039"], "canonical_name": "positive regulation of central tolerance induction", "definition": "Any process that activates or increases the frequency, rate, or extent of central tolerance induction. [GOC:add]"}
{"concept_id": "C1818763", "aliases": [], "types": ["T038"], "canonical_name": "regulation of tolerance induction to self antigen", "definition": "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen. [GOC:add]"}
{"concept_id": "C1818764", "aliases": ["downregulation of tolerance induction to self antigen", "down-regulation of tolerance induction to self antigen", "down regulation of tolerance induction to self antigen"], "types": ["T039"], "canonical_name": "negative regulation of tolerance induction to self antigen", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen. [GOC:add]"}
{"concept_id": "C1818765", "aliases": ["up-regulation of tolerance induction to self antigen", "upregulation of tolerance induction to self antigen", "up regulation of tolerance induction to self antigen"], "types": ["T039"], "canonical_name": "positive regulation of tolerance induction to self antigen", "definition": "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen. [GOC:add]"}
{"concept_id": "C1818766", "aliases": ["regulation of immune response-dependent tolerance induction"], "types": ["T038"], "canonical_name": "regulation of tolerance induction dependent upon immune response", "definition": "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response. [GOC:add]"}
{"concept_id": "C1818767", "aliases": ["downregulation of tolerance induction dependent upon immune response", "negative regulation of immune response-dependent tolerance induction", "down regulation of tolerance induction dependent upon immune response", "down-regulation of tolerance induction dependent upon immune response"], "types": ["T039"], "canonical_name": "negative regulation of tolerance induction dependent upon immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response. [GOC:add]"}
{"concept_id": "C1818768", "aliases": ["up-regulation of tolerance induction dependent upon immune response", "up regulation of tolerance induction dependent upon immune response", "positive regulation of immune response-dependent tolerance induction", "upregulation of tolerance induction dependent upon immune response"], "types": ["T039"], "canonical_name": "positive regulation of tolerance induction dependent upon immune response", "definition": "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response. [GOC:add]"}
{"concept_id": "C1818769", "aliases": [], "types": ["T038"], "canonical_name": "regulation of tolerance induction to nonself antigen", "definition": "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen. [GOC:add]"}
{"concept_id": "C1818770", "aliases": ["down regulation of tolerance induction to nonself antigen", "down-regulation of tolerance induction to nonself antigen", "downregulation of tolerance induction to nonself antigen"], "types": ["T039"], "canonical_name": "negative regulation of tolerance induction to nonself antigen", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen. [GOC:add]"}
{"concept_id": "C1818771", "aliases": ["upregulation of tolerance induction to nonself antigen", "up-regulation of tolerance induction to nonself antigen", "up regulation of tolerance induction to nonself antigen"], "types": ["T039"], "canonical_name": "positive regulation of tolerance induction to nonself antigen", "definition": "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen. [GOC:add]"}
{"concept_id": "C1818772", "aliases": [], "types": ["T038"], "canonical_name": "regulation of peripheral tolerance induction", "definition": "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction. [GOC:add]"}
{"concept_id": "C1818773", "aliases": ["down-regulation of peripheral tolerance induction", "downregulation of peripheral tolerance induction", "down regulation of peripheral tolerance induction"], "types": ["T039"], "canonical_name": "negative regulation of peripheral tolerance induction", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction. [GOC:add]"}
{"concept_id": "C1818774", "aliases": ["up-regulation of peripheral tolerance induction", "upregulation of peripheral tolerance induction", "up regulation of peripheral tolerance induction"], "types": ["T039"], "canonical_name": "positive regulation of peripheral tolerance induction", "definition": "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction. [GOC:add]"}
{"concept_id": "C1818775", "aliases": ["regulation of B-lymphocyte tolerance induction", "regulation of B lymphocyte tolerance induction", "regulation of B-cell tolerance induction"], "types": ["T038"], "canonical_name": "regulation of B cell tolerance induction", "definition": "Any process that modulates the frequency, rate, or extent of B cell tolerance induction. [GOC:add]"}
{"concept_id": "C1818776", "aliases": ["negative regulation of B-lymphocyte tolerance induction", "down-regulation of B cell tolerance induction", "negative regulation of B-cell tolerance induction", "negative regulation of B lymphocyte tolerance induction", "downregulation of B cell tolerance induction", "down regulation of B cell tolerance induction"], "types": ["T039"], "canonical_name": "negative regulation of B cell tolerance induction", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction. [GOC:add]"}
{"concept_id": "C1818777", "aliases": ["up regulation of B cell tolerance induction", "up-regulation of B cell tolerance induction", "upregulation of B cell tolerance induction", "positive regulation of B-cell tolerance induction", "positive regulation of B lymphocyte tolerance induction", "positive regulation of B-lymphocyte tolerance induction"], "types": ["T039"], "canonical_name": "positive regulation of B cell tolerance induction", "definition": "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction. [GOC:add]"}
{"concept_id": "C1818778", "aliases": ["regulation of T-lymphocyte tolerance induction", "regulation of T-cell tolerance induction", "regulation of T lymphocyte tolerance induction"], "types": ["T043"], "canonical_name": "regulation of T cell tolerance induction", "definition": "Any process that modulates the frequency, rate, or extent of T cell tolerance induction. [GOC:add]"}
{"concept_id": "C1818779", "aliases": ["down regulation of T cell tolerance induction", "negative regulation of T lymphocyte tolerance induction", "negative regulation of T-lymphocyte tolerance induction", "negative regulation of T-cell tolerance induction", "down-regulation of T cell tolerance induction", "downregulation of T cell tolerance induction"], "types": ["T039"], "canonical_name": "negative regulation of T cell tolerance induction", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction. [GOC:add]"}
{"concept_id": "C1818780", "aliases": ["up-regulation of T cell tolerance induction", "up regulation of T cell tolerance induction", "positive regulation of T-cell tolerance induction", "positive regulation of T-lymphocyte tolerance induction", "upregulation of T cell tolerance induction", "positive regulation of T lymphocyte tolerance induction"], "types": ["T039"], "canonical_name": "positive regulation of T cell tolerance induction", "definition": "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction. [GOC:add]"}
{"concept_id": "C1818781", "aliases": ["regulation of T lymphocyte anergy", "regulation of T-cell anergy", "regulation of T-lymphocyte anergy"], "types": ["T043"], "canonical_name": "regulation of T cell anergy", "definition": "Any process that modulates the frequency, rate, or extent of T cell anergy. [GOC:add]"}
{"concept_id": "C1818782", "aliases": ["downregulation of T cell anergy", "negative regulation of T-lymphocyte anergy", "negative regulation of T lymphocyte anergy", "down-regulation of T cell anergy", "negative regulation of T-cell anergy", "down regulation of T cell anergy"], "types": ["T043"], "canonical_name": "negative regulation of T cell anergy", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy. [GOC:add]"}
{"concept_id": "C1818783", "aliases": ["up regulation of T cell anergy", "positive regulation of T-cell anergy", "up-regulation of T cell anergy", "positive regulation of T-lymphocyte anergy", "upregulation of T cell anergy", "positive regulation of T lymphocyte anergy"], "types": ["T043"], "canonical_name": "positive regulation of T cell anergy", "definition": "Any process that activates or increases the frequency, rate, or extent of T cell anergy. [GOC:add]"}
{"concept_id": "C1818784", "aliases": ["regulation of B-cell anergy", "regulation of B-lymphocyte anergy", "regulation of B lymphocyte anergy"], "types": ["T043"], "canonical_name": "regulation of B cell anergy", "definition": "Any process that modulates the frequency, rate, or extent of B cell anergy. [GOC:add]"}
{"concept_id": "C1818785", "aliases": ["negative regulation of B-lymphocyte anergy", "negative regulation of B lymphocyte anergy", "negative regulation of B-cell anergy", "down regulation of B cell anergy", "down-regulation of B cell anergy", "downregulation of B cell anergy"], "types": ["T043"], "canonical_name": "negative regulation of B cell anergy", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy. [GOC:add]"}
{"concept_id": "C1818786", "aliases": ["up regulation of B cell anergy", "positive regulation of B-cell anergy", "positive regulation of B lymphocyte anergy", "upregulation of B cell anergy", "positive regulation of B-lymphocyte anergy", "up-regulation of B cell anergy"], "types": ["T043"], "canonical_name": "positive regulation of B cell anergy", "definition": "Any process that activates or increases the frequency, rate, or extent of B cell anergy. [GOC:add]"}
{"concept_id": "C1818787", "aliases": [], "types": ["T046"], "canonical_name": "regulation of acute inflammatory response", "definition": "Any process that modulates the frequency, rate, or extent of an acute inflammatory response. [GOC:add]"}
{"concept_id": "C1818788", "aliases": ["down-regulation of acute inflammatory response", "down regulation of acute inflammatory response", "downregulation of acute inflammatory response"], "types": ["T040"], "canonical_name": "negative regulation of acute inflammatory response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. [GOC:add]"}
{"concept_id": "C1818789", "aliases": ["upregulation of acute inflammatory response", "up regulation of acute inflammatory response", "up-regulation of acute inflammatory response"], "types": ["T040"], "canonical_name": "positive regulation of acute inflammatory response", "definition": "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. [GOC:add]"}
{"concept_id": "C1818790", "aliases": [], "types": ["T046"], "canonical_name": "regulation of chronic inflammatory response", "definition": "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. [GOC:add]"}
{"concept_id": "C1818791", "aliases": ["down-regulation of chronic inflammatory response", "down regulation of chronic inflammatory response", "downregulation of chronic inflammatory response"], "types": ["T040"], "canonical_name": "negative regulation of chronic inflammatory response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response. [GOC:add]"}
{"concept_id": "C1818792", "aliases": ["upregulation of chronic inflammatory response", "up regulation of chronic inflammatory response", "up-regulation of chronic inflammatory response"], "types": ["T040"], "canonical_name": "positive regulation of chronic inflammatory response", "definition": "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response. [GOC:add]"}
{"concept_id": "C1818794", "aliases": ["pro-T cell fate commitment", "pro-T lymphocyte lineage commitment", "pro-T lymphocyte fate commitment"], "types": ["T043"], "canonical_name": "pro-T cell lineage commitment", "definition": "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818795", "aliases": ["somatic recombination of TCR gene segments"], "types": ["T045"], "canonical_name": "somatic recombination of T cell receptor gene segments", "definition": "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1818796", "aliases": [], "types": ["T038"], "canonical_name": "regulation of immune system process", "definition": "Any process that modulates the frequency, rate, or extent of an immune system process. [GOC:add]"}
{"concept_id": "C1818797", "aliases": ["down regulation of immune system process", "downregulation of immune system process", "down-regulation of immune system process"], "types": ["T039"], "canonical_name": "negative regulation of immune system process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. [GOC:add]"}
{"concept_id": "C1818798", "aliases": ["up regulation of immune system process", "upregulation of immune system process", "up-regulation of immune system process"], "types": ["T039"], "canonical_name": "positive regulation of immune system process", "definition": "Any process that activates or increases the frequency, rate, or extent of an immune system process. [GOC:add]"}
{"concept_id": "C1818799", "aliases": ["regulation of leucocyte migration", "regulation of immune cell migration"], "types": ["T043"], "canonical_name": "regulation of leukocyte migration", "definition": "Any process that modulates the frequency, rate, or extent of leukocyte migration. [GOC:add]"}
{"concept_id": "C1818800", "aliases": ["downregulation of leukocyte migration", "down regulation of leukocyte migration", "negative regulation of leucocyte migration", "negative regulation of immune cell migration", "down-regulation of leukocyte migration"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte migration", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. [GOC:add]"}
{"concept_id": "C1818801", "aliases": ["positive regulation of immune cell migration", "up regulation of leukocyte migration", "up-regulation of leukocyte migration", "positive regulation of leucocyte migration", "upregulation of leukocyte migration"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte migration", "definition": "Any process that activates or increases the frequency, rate, or extent of leukocyte migration. [GOC:add]"}
{"concept_id": "C1818802", "aliases": ["regulation of immune cell chemotaxis", "regulation of leucocyte chemotaxis"], "types": ["T043"], "canonical_name": "regulation of leukocyte chemotaxis", "definition": "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]"}
{"concept_id": "C1818803", "aliases": ["downregulation of leukocyte chemotaxis", "down regulation of leukocyte chemotaxis", "down-regulation of leukocyte chemotaxis", "negative regulation of immune cell chemotaxis", "negative regulation of leucocyte chemotaxis"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte chemotaxis", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]"}
{"concept_id": "C1818804", "aliases": ["positive regulation of leucocyte chemotaxis", "up regulation of leukocyte chemotaxis", "positive regulation of immune cell chemotaxis", "up-regulation of leukocyte chemotaxis", "upregulation of leukocyte chemotaxis"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte chemotaxis", "definition": "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]"}
{"concept_id": "C1818805", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular extravasation", "definition": "Any process that modulates the frequency, rate, or extent of cellular extravasation. [GOC:add]"}
{"concept_id": "C1818806", "aliases": ["downregulation of cellular extravasation", "down regulation of cellular extravasation", "down-regulation of cellular extravasation"], "types": ["T043"], "canonical_name": "negative regulation of cellular extravasation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation. [GOC:add]"}
{"concept_id": "C1818807", "aliases": ["up regulation of cellular extravasation", "upregulation of cellular extravasation", "up-regulation of cellular extravasation"], "types": ["T043"], "canonical_name": "positive regulation of cellular extravasation", "definition": "Any process that activates or increases the frequency, rate, or extent of cellular extravasation. [GOC:add]"}
{"concept_id": "C1818808", "aliases": ["regulation of leucocyte activation", "regulation of immune cell activation"], "types": ["T043"], "canonical_name": "regulation of leukocyte activation", "definition": "Any process that modulates the frequency, rate, or extent of leukocyte activation. [GOC:add]"}
{"concept_id": "C1818810", "aliases": ["positive regulation of leucocyte activation", "up-regulation of leukocyte activation", "positive regulation of immune cell activation", "up regulation of leukocyte activation", "upregulation of leukocyte activation"], "types": ["T039"], "canonical_name": "positive regulation of leukocyte activation", "definition": "Any process that activates or increases the frequency, rate, or extent of leukocyte activation. [GOC:add]"}
{"concept_id": "C1818811", "aliases": [], "types": ["T038"], "canonical_name": "regulation of immune effector process", "definition": "Any process that modulates the frequency, rate, or extent of an immune effector process. [GOC:add]"}
{"concept_id": "C1818812", "aliases": ["down regulation of immune effector process", "downregulation of immune effector process", "down-regulation of immune effector process"], "types": ["T039"], "canonical_name": "negative regulation of immune effector process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. [GOC:add]"}
{"concept_id": "C1818813", "aliases": ["up regulation of immune effector process", "upregulation of immune effector process", "up-regulation of immune effector process"], "types": ["T039"], "canonical_name": "positive regulation of immune effector process", "definition": "Any process that activates or increases the frequency, rate, or extent of an immune effector process. [GOC:add]"}
{"concept_id": "C1818814", "aliases": [], "types": ["T038"], "canonical_name": "regulation of production of molecular mediator of immune response", "definition": "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. [GOC:add]"}
{"concept_id": "C1818815", "aliases": ["downregulation of production of molecular mediator of immune response", "down-regulation of production of molecular mediator of immune response", "down regulation of production of molecular mediator of immune response"], "types": ["T039"], "canonical_name": "negative regulation of production of molecular mediator of immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. [GOC:add]"}
{"concept_id": "C1818816", "aliases": ["up regulation of production of molecular mediator of immune response", "upregulation of production of molecular mediator of immune response", "up-regulation of production of molecular mediator of immune response"], "types": ["T039"], "canonical_name": "positive regulation of production of molecular mediator of immune response", "definition": "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. [GOC:add]"}
{"concept_id": "C1818817", "aliases": ["regulation of immune cell mediated immunity", "regulation of leucocyte mediated immunity"], "types": ["T038"], "canonical_name": "regulation of leukocyte mediated immunity", "definition": "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]"}
{"concept_id": "C1818818", "aliases": ["down-regulation of leukocyte mediated immunity", "downregulation of leukocyte mediated immunity", "down regulation of leukocyte mediated immunity", "negative regulation of leucocyte mediated immunity", "negative regulation of immune cell mediated immunity"], "types": ["T039"], "canonical_name": "negative regulation of leukocyte mediated immunity", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]"}
{"concept_id": "C1818819", "aliases": ["positive regulation of leucocyte mediated immunity", "up regulation of leukocyte mediated immunity", "positive regulation of immune cell mediated immunity", "upregulation of leukocyte mediated immunity", "up-regulation of leukocyte mediated immunity"], "types": ["T039"], "canonical_name": "positive regulation of leukocyte mediated immunity", "definition": "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]"}
{"concept_id": "C1818820", "aliases": [], "types": ["T038"], "canonical_name": "regulation of lymphocyte mediated immunity", "definition": "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. [GOC:add]"}
{"concept_id": "C1818821", "aliases": ["downregulation of lymphocyte mediated immunity", "down regulation of lymphocyte mediated immunity", "down-regulation of lymphocyte mediated immunity"], "types": ["T039"], "canonical_name": "negative regulation of lymphocyte mediated immunity", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. [GOC:add]"}
{"concept_id": "C1818822", "aliases": ["up-regulation of lymphocyte mediated immunity", "upregulation of lymphocyte mediated immunity", "up regulation of lymphocyte mediated immunity"], "types": ["T039"], "canonical_name": "positive regulation of lymphocyte mediated immunity", "definition": "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. [GOC:add]"}
{"concept_id": "C1818823", "aliases": ["regulation of T-cell mediated immunity", "regulation of T-lymphocyte mediated immunity", "regulation of T lymphocyte mediated immunity"], "types": ["T038"], "canonical_name": "regulation of T cell mediated immunity", "definition": "Any process that modulates the frequency, rate, or extent of T cell mediated immunity. [GOC:add]"}
{"concept_id": "C1818824", "aliases": ["negative regulation of T-cell mediated immunity", "down regulation of T cell mediated immunity", "down-regulation of T cell mediated immunity", "downregulation of T cell mediated immunity", "negative regulation of T-lymphocyte mediated immunity", "negative regulation of T lymphocyte mediated immunity"], "types": ["T040"], "canonical_name": "negative regulation of T cell mediated immunity", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. [GOC:add]"}
{"concept_id": "C1818825", "aliases": ["positive regulation of T-lymphocyte mediated immunity", "up regulation of T cell mediated immunity", "upregulation of T cell mediated immunity", "positive regulation of T-cell mediated immunity", "positive regulation of T lymphocyte mediated immunity", "up-regulation of T cell mediated immunity"], "types": ["T040"], "canonical_name": "positive regulation of T cell mediated immunity", "definition": "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. [GOC:add]"}
{"concept_id": "C1818826", "aliases": ["ubiquitin-like protein modifier"], "types": ["T044"], "canonical_name": "protein tag", "definition": "A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. [GOC:dos, GOC:go_curators, PMID:19028679, PMID:20054389, PMID:6305978]"}
{"concept_id": "C1818827", "aliases": [], "types": ["T026"], "canonical_name": "ethanolamine metabolosome"}
{"concept_id": "C1818828", "aliases": ["myosin IV complex location"], "types": ["T026"], "canonical_name": "myosin IV complex", "definition": "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV. [Wikipedia:Myosin]"}
{"concept_id": "C1818829", "aliases": ["myosin V complex location"], "types": ["T026"], "canonical_name": "myosin V complex", "definition": "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region. [Wikipedia:Myosin]"}
{"concept_id": "C1818830", "aliases": ["myosin VI complex location"], "types": ["T026"], "canonical_name": "myosin VI complex", "definition": "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818831", "aliases": ["myosin VII complex location"], "types": ["T026"], "canonical_name": "myosin VII complex", "definition": "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818832", "aliases": ["myosin VIII complex location"], "types": ["T026"], "canonical_name": "myosin VIII complex", "definition": "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818833", "aliases": ["myosin IX complex location"], "types": ["T026"], "canonical_name": "myosin IX complex", "definition": "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818834", "aliases": ["myosin X complex location"], "types": ["T026"], "canonical_name": "myosin X complex", "definition": "A myosin complex containing one or more class X myosin heavy chains and associated light chains. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818835", "aliases": ["myosin XI complex location"], "types": ["T026"], "canonical_name": "myosin XI complex", "definition": "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818836", "aliases": ["myosin XII complex location"], "types": ["T026"], "canonical_name": "myosin XII complex", "definition": "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818837", "aliases": ["myosin XIII complex location"], "types": ["T026"], "canonical_name": "myosin XIII complex", "definition": "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818838", "aliases": ["myosin XIV complex location"], "types": ["T026"], "canonical_name": "myosin XIV complex", "definition": "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818839", "aliases": ["myosin XV complex location"], "types": ["T026"], "canonical_name": "myosin XV complex", "definition": "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818840", "aliases": ["myosin XVI complex location"], "types": ["T026"], "canonical_name": "myosin XVI complex", "definition": "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886]"}
{"concept_id": "C1818841", "aliases": ["myosin XVII complex location"], "types": ["T026"], "canonical_name": "myosin XVII complex", "definition": "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains. [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1818842", "aliases": ["myosin XVIII complex location"], "types": ["T026"], "canonical_name": "myosin XVIII complex", "definition": "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain. [PMID:11294886]"}
{"concept_id": "C1818843", "aliases": [], "types": ["T043"], "canonical_name": "primary cell septum biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division. [GOC:jl]"}
{"concept_id": "C1818844", "aliases": [], "types": ["T044"], "canonical_name": "EP1 subtype prostaglandin E2 receptor ligand"}
{"concept_id": "C1818845", "aliases": [], "types": ["T044"], "canonical_name": "EP2 subtype prostaglandin E2 receptor ligand"}
{"concept_id": "C1818846", "aliases": [], "types": ["T044"], "canonical_name": "EP3 subtype prostaglandin E2 receptor ligand"}
{"concept_id": "C1818847", "aliases": [], "types": ["T044"], "canonical_name": "EP4 subtype prostaglandin E2 receptor ligand"}
{"concept_id": "C1818848", "aliases": [], "types": ["T044"], "canonical_name": "prostaglandin F2-alpha receptor ligand"}
{"concept_id": "C1818849", "aliases": [], "types": ["T044"], "canonical_name": "regulation of glucocorticoid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. [GOC:mah]"}
{"concept_id": "C1818850", "aliases": ["down regulation of glucocorticoid biosynthetic process", "down-regulation of glucocorticoid biosynthetic process", "downregulation of glucocorticoid biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of glucocorticoid biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. [GOC:mah]"}
{"concept_id": "C1818851", "aliases": ["up regulation of glucocorticoid biosynthetic process", "upregulation of glucocorticoid biosynthetic process", "up-regulation of glucocorticoid biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of glucocorticoid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. [GOC:mah]"}
{"concept_id": "C1818852", "aliases": [], "types": ["T044"], "canonical_name": "regulation of glucocorticoid catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. [GOC:mah]"}
{"concept_id": "C1818853", "aliases": ["down-regulation of glucocorticoid catabolic process", "down regulation of glucocorticoid catabolic process", "downregulation of glucocorticoid catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of glucocorticoid catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. [GOC:mah]"}
{"concept_id": "C1818854", "aliases": ["upregulation of glucocorticoid catabolic process", "up regulation of glucocorticoid catabolic process", "up-regulation of glucocorticoid catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of glucocorticoid catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. [GOC:mah]"}
{"concept_id": "C1818855", "aliases": ["regulation of target of rapamycin signaling pathway", "regulation of TOR signaling cascade", "regulation of TOR signalling pathway", "regulation of target of rapamycin signalling pathway", "regulation of TOR signaling pathway"], "types": ["T044"], "canonical_name": "regulation of TOR signaling", "definition": "Any process that modulates the frequency, rate or extent of TOR signaling. [GOC:mah]"}
{"concept_id": "C1818856", "aliases": ["negative regulation of TOR signaling pathway", "negative regulation of target of rapamycin signaling pathway", "negative regulation of target of rapamycin signalling pathway", "downregulation of TOR signaling pathway", "negative regulation of TOR signalling pathway", "down-regulation of TOR signaling pathway", "negative regulation of TOR signaling cascade", "down regulation of TOR signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of TOR signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. [GOC:mah]"}
{"concept_id": "C1818858", "aliases": ["early phagocytic vesicle"], "types": ["T026"], "canonical_name": "early phagosome", "definition": "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis. [GOC:mah, PMID:12388753]"}
{"concept_id": "C1818859", "aliases": [], "types": ["T026"], "canonical_name": "late phagocytic vesicle"}
{"concept_id": "C1818860", "aliases": [], "types": ["T026"], "canonical_name": "late phagosome"}
{"concept_id": "C1818861", "aliases": [], "types": ["T044"], "canonical_name": "ARF protein signal transduction", "definition": "The series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state. [GOC:mah]"}
{"concept_id": "C1818862", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ARF protein signal transduction", "definition": "Any process that modulates the frequency, rate or extent of ARF protein signal transduction. [GOC:mah]"}
{"concept_id": "C1818863", "aliases": ["downregulation of ARF protein signal transduction", "down-regulation of ARF protein signal transduction", "down regulation of ARF protein signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of ARF protein signal transduction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction. [GOC:mah]"}
{"concept_id": "C1818864", "aliases": ["upregulation of ARF protein signal transduction", "up regulation of ARF protein signal transduction", "up-regulation of ARF protein signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of ARF protein signal transduction", "definition": "Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction. [GOC:mah]"}
{"concept_id": "C1818865", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Ran protein signal transduction", "definition": "Any process that modulates the frequency, rate or extent of Ran protein signal transduction. [GOC:mah]"}
{"concept_id": "C1818866", "aliases": ["downregulation of Ran protein signal transduction", "down-regulation of Ran protein signal transduction", "down regulation of Ran protein signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of Ran protein signal transduction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction. [GOC:mah]"}
{"concept_id": "C1818867", "aliases": ["upregulation of Ran protein signal transduction", "up-regulation of Ran protein signal transduction", "up regulation of Ran protein signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of Ran protein signal transduction", "definition": "Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction. [GOC:mah]"}
{"concept_id": "C1818868", "aliases": ["2-methylbutanal reductase (NADP) activity", "2-methylbutyraldehyde reductase (NADP) activity"], "types": ["T044"], "canonical_name": "2-methylbutanol:NADP oxidoreductase activity", "definition": "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+. [GOC:mah, PMID:12210903]"}
{"concept_id": "C1818869", "aliases": [], "types": ["T044"], "canonical_name": "ISG15-protein conjugation", "definition": "The covalent addition to a protein of ISG15, a ubiquitin-like protein. [GOC:mah]"}
{"concept_id": "C1818870", "aliases": ["negative elongation factor complex", "NELF complex location", "negative elongation factor complex location"], "types": ["T026"], "definition": "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing. [PMID:12612062]", "canonical_name": "NELF complex"}
{"concept_id": "C1818872", "aliases": ["cleavage of trypsinogen to trypsin"], "types": ["T044"], "canonical_name": "trypsinogen activation", "definition": "The proteolytic processing of trypsinogen to the active form, trypsin. [GOC:mah]"}
{"concept_id": "C1818873", "aliases": ["up-regulation of insulin secretion", "upregulation of insulin secretion", "up regulation of insulin secretion"], "types": ["T043"], "canonical_name": "positive regulation of insulin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]"}
{"concept_id": "C1818874", "aliases": [], "types": ["T043"], "canonical_name": "response to cobalt ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. [GOC:mah]"}
{"concept_id": "C1818875", "aliases": [], "types": ["T043"], "canonical_name": "response to magnesium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah]"}
{"concept_id": "C1818876", "aliases": [], "types": ["T044"], "canonical_name": "myosin light chain binding", "definition": "Binding to a light chain of a myosin complex. [GOC:mah]"}
{"concept_id": "C1818877", "aliases": [], "types": ["T044"], "canonical_name": "myosin head/neck binding", "definition": "Binding to the head/neck region of a myosin heavy chain. [GOC:mah]"}
{"concept_id": "C1818878", "aliases": [], "types": ["T044"], "canonical_name": "myosin tail binding", "definition": "Binding to the tail region of a myosin heavy chain. [GOC:mah]"}
{"concept_id": "C1818879", "aliases": [], "types": ["T044"], "canonical_name": "myosin I light chain binding", "definition": "Binding to a light chain of a myosin I complex. [GOC:mah]"}
{"concept_id": "C1818880", "aliases": [], "types": ["T044"], "canonical_name": "myosin I head/neck binding", "definition": "Binding to the head/neck region of a myosin I heavy chain. [GOC:mah]"}
{"concept_id": "C1818881", "aliases": [], "types": ["T044"], "canonical_name": "myosin I tail binding", "definition": "Binding to the tail region of a myosin I heavy chain. [GOC:mah]"}
{"concept_id": "C1818882", "aliases": [], "types": ["T044"], "canonical_name": "myosin II light chain binding", "definition": "Binding to a light chain of a myosin II complex. [GOC:mah]"}
{"concept_id": "C1818883", "aliases": [], "types": ["T044"], "canonical_name": "myosin II head/neck binding", "definition": "Binding to the head/neck region of a myosin II heavy chain. [GOC:mah]"}
{"concept_id": "C1818884", "aliases": [], "types": ["T044"], "canonical_name": "myosin II tail binding", "definition": "Binding to the tail region of a myosin II heavy chain. [GOC:mah]"}
{"concept_id": "C1818885", "aliases": [], "types": ["T044"], "canonical_name": "myosin heavy chain binding", "definition": "Binding to a heavy chain of a myosin complex. [GOC:mah]"}
{"concept_id": "C1818886", "aliases": [], "types": ["T044"], "canonical_name": "myosin I heavy chain binding", "definition": "Binding to a heavy chain of a myosin I complex. [GOC:mah]"}
{"concept_id": "C1818887", "aliases": [], "types": ["T044"], "canonical_name": "myosin II heavy chain binding", "definition": "Binding to a heavy chain of a myosin II complex. [GOC:mah]"}
{"concept_id": "C1818888", "aliases": ["integrator complex location"], "types": ["T026"], "canonical_name": "integrator complex", "definition": "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. [PMID:16239144]"}
{"concept_id": "C1818889", "aliases": ["small subunit processome", "SSU processome"], "types": ["T026"], "canonical_name": "small-subunit processome", "definition": "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]"}
{"concept_id": "C1818890", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent histone deacetylase activity (H3-K14 specific)", "definition": "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. [PMID:28450737]"}
{"concept_id": "C1818891", "aliases": ["mtDNA metabolic process", "mtDNA metabolism", "mitochondrial DNA metabolism"], "types": ["T045"], "canonical_name": "mitochondrial DNA metabolic process", "definition": "The chemical reactions and pathways involving mitochondrial DNA. [GOC:mah]"}
{"concept_id": "C1818892", "aliases": ["mitochondrial DNA breakdown", "mitochondrial DNA catabolism", "mtDNA catabolism", "mitochondrial DNA degradation", "mtDNA degradation", "mtDNA catabolic process", "mtDNA breakdown"], "types": ["T045"], "canonical_name": "mitochondrial DNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA. [GOC:mah]"}
{"concept_id": "C1818893", "aliases": ["DRB sensitivity inducing factor complex location", "Spt4-Spt5 complex location", "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex", "DSIF complex location", "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex location", "Spt4-Spt5 complex", "Spt5-Spt4 complex location", "DRB sensitivity inducing factor complex", "Spt5-Spt4 complex"], "types": ["T026"], "canonical_name": "DSIF complex", "definition": "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes. [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865]"}
{"concept_id": "C1818894", "aliases": ["guanyl-nucleotide exchange factor complex location"], "types": ["T026"], "canonical_name": "guanyl-nucleotide exchange factor complex", "definition": "A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. [GOC:mah]"}
{"concept_id": "C1818895", "aliases": ["MIPA", "micropexophagic apparatus"], "types": ["T026"], "canonical_name": "micropexophagy-specific membrane apparatus", "definition": "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole. [PMID:15563611]"}
{"concept_id": "C1818896", "aliases": ["crypton"], "types": ["T026"], "canonical_name": "mitosome", "definition": "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria. [GOC:giardia, PMID:10361303, PMID:14614504, PMID:24316280]"}
{"concept_id": "C1818897", "aliases": ["cardiolipin metabolism"], "types": ["T044"], "canonical_name": "cardiolipin metabolic process", "definition": "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. [GOC:mah]"}
{"concept_id": "C1818898", "aliases": [], "types": ["T044"], "canonical_name": "diphosphatidylglycerol metabolic process"}
{"concept_id": "C1818899", "aliases": [], "types": ["T044"], "canonical_name": "diphosphatidylglycerol metabolism"}
{"concept_id": "C1818900", "aliases": [], "types": ["T044"], "canonical_name": "cardiolipin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. [GOC:mah]"}
{"concept_id": "C1818901", "aliases": ["diphosphatidylglycerol biosynthetic process"], "types": ["T044"], "canonical_name": "diphosphatidylglycerol biosynthesis"}
{"concept_id": "C1818902", "aliases": [], "types": ["T044"], "canonical_name": "clathrin heavy chain binding", "definition": "Binding to a clathrin heavy chain. [GOC:mah]"}
{"concept_id": "C1818903", "aliases": [], "types": ["T044"], "canonical_name": "clathrin light chain binding", "definition": "Binding to a clathrin light chain. [GOC:mah]"}
{"concept_id": "C1818904", "aliases": [], "types": ["T044"], "canonical_name": "bile acid binding", "definition": "Binding to a bile acid, a steroid carboxylic acids occurring in bile. [GOC:rph]"}
{"concept_id": "C1818907", "aliases": ["down regulation of translation in response to stress", "downregulation of translation in response to stress", "down-regulation of translation in response to stress"], "types": ["T045"], "canonical_name": "negative regulation of translation in response to stress", "definition": "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress. [GOC:mah]"}
{"concept_id": "C1818908", "aliases": ["upregulation of translation in response to stress", "up-regulation of translation in response to stress", "up regulation of translation in response to stress"], "types": ["T043"], "canonical_name": "positive regulation of translation in response to stress", "definition": "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. [GOC:mah]"}
{"concept_id": "C1818912", "aliases": ["down-regulation of translation in response to osmotic stress", "downregulation of translation in response to osmotic stress", "down regulation of translation in response to osmotic stress"], "types": ["T043"], "canonical_name": "negative regulation of translation in response to osmotic stress", "definition": "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:mah]"}
{"concept_id": "C1818913", "aliases": ["up-regulation of translation in response to osmotic stress", "up regulation of translation in response to osmotic stress", "upregulation of translation in response to osmotic stress"], "types": ["T043"], "canonical_name": "positive regulation of translation in response to osmotic stress", "definition": "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:mah]"}
{"concept_id": "C1818916", "aliases": ["cortical protein anchoring"], "types": ["T043"], "canonical_name": "maintenance of protein location in cell cortex", "definition": "A process in which a protein or protein complex is maintained in a specific location in the cell cortex. [GOC:vw]"}
{"concept_id": "C1818918", "aliases": ["type IV restriction enzyme activity"], "types": ["T045"], "canonical_name": "type IV site-specific deoxyribonuclease activity", "definition": "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated). [PMID:12654995]"}
{"concept_id": "C1818919", "aliases": ["type IV restriction enzyme complex", "type IV restriction enzyme complex location", "type IV site-specific deoxyribonuclease complex location"], "types": ["T026"], "canonical_name": "type IV site-specific deoxyribonuclease complex", "definition": "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation. [PMID:12654995]"}
{"concept_id": "C1818920", "aliases": [], "types": ["T044"], "canonical_name": "regulation of nuclease activity", "definition": "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. [GOC:mah]"}
{"concept_id": "C1818921", "aliases": [], "types": ["T044"], "canonical_name": "nuclease regulator activity"}
{"concept_id": "C1818922", "aliases": [], "types": ["T044"], "canonical_name": "regulation of deoxyribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. [GOC:mah]"}
{"concept_id": "C1818923", "aliases": ["DNase regulator"], "types": ["T044"], "canonical_name": "deoxyribonuclease regulator"}
{"concept_id": "C1818924", "aliases": [], "types": ["T044"], "canonical_name": "regulation of endodeoxyribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. [GOC:mah]"}
{"concept_id": "C1818925", "aliases": [], "types": ["T044"], "canonical_name": "endodeoxyribonuclease regulator"}
{"concept_id": "C1818926", "aliases": [], "types": ["T044"], "canonical_name": "regulation of restriction endodeoxyribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. [GOC:mah]"}
{"concept_id": "C1818927", "aliases": ["down regulation of restriction endodeoxyribonuclease activity", "down-regulation of restriction endodeoxyribonuclease activity", "downregulation of restriction endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of restriction endodeoxyribonuclease activity", "definition": "Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. [GOC:mah]"}
{"concept_id": "C1818928", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of restriction endodeoxyribonuclease activity"}
{"concept_id": "C1818929", "aliases": [], "types": ["T044"], "canonical_name": "restriction endodeoxyribonuclease inhibitor"}
{"concept_id": "C1818930", "aliases": [], "types": ["T044"], "canonical_name": "restriction enzyme inhibitor"}
{"concept_id": "C1818931", "aliases": ["downregulation of nuclease activity", "down regulation of nuclease activity", "down-regulation of nuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of nuclease activity", "definition": "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. [GOC:mah]"}
{"concept_id": "C1818932", "aliases": [], "types": ["T044"], "canonical_name": "nuclease inhibitor"}
{"concept_id": "C1818933", "aliases": ["up-regulation of nuclease activity", "up regulation of nuclease activity", "upregulation of nuclease activity"], "types": ["T044"], "canonical_name": "positive regulation of nuclease activity", "definition": "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. [GOC:mah]"}
{"concept_id": "C1818934", "aliases": [], "types": ["T044"], "canonical_name": "nuclease activator"}
{"concept_id": "C1818935", "aliases": ["down regulation of deoxyribonuclease activity", "downregulation of deoxyribonuclease activity", "down-regulation of deoxyribonuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of deoxyribonuclease activity", "definition": "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. [GOC:mah]"}
{"concept_id": "C1818936", "aliases": ["DNase inhibitor"], "types": ["T044"], "canonical_name": "deoxyribonuclease inhibitor"}
{"concept_id": "C1818937", "aliases": ["up-regulation of deoxyribonuclease activity", "upregulation of deoxyribonuclease activity", "up regulation of deoxyribonuclease activity"], "types": ["T044"], "canonical_name": "positive regulation of deoxyribonuclease activity", "definition": "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. [GOC:mah]"}
{"concept_id": "C1818938", "aliases": ["DNase activator"], "types": ["T044"], "canonical_name": "deoxyribonuclease activator"}
{"concept_id": "C1818939", "aliases": ["downregulation of endodeoxyribonuclease activity", "down regulation of endodeoxyribonuclease activity", "down-regulation of endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of endodeoxyribonuclease activity", "definition": "Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. [GOC:mah]"}
{"concept_id": "C1818940", "aliases": [], "types": ["T044"], "canonical_name": "endodeoxyribonuclease inhibitor"}
{"concept_id": "C1818941", "aliases": ["upregulation of endodeoxyribonuclease activity", "up regulation of endodeoxyribonuclease activity", "up-regulation of endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "positive regulation of endodeoxyribonuclease activity", "definition": "Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. [GOC:mah]"}
{"concept_id": "C1818942", "aliases": [], "types": ["T044"], "canonical_name": "endodeoxyribonuclease activator"}
{"concept_id": "C1818943", "aliases": ["negative regulation of type I restriction endodeoxyribonuclease activity", "down regulation of type I restriction endodeoxyribonuclease activity", "down-regulation of type I restriction endodeoxyribonuclease activity", "downregulation of type I restriction endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of type I site-specific deoxyribonuclease activity", "definition": "Any process that stops or reduces the rate of type I restriction endodeoxyribonuclease activity. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1818944", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of type I restriction endodeoxyribonuclease activity"}
{"concept_id": "C1818945", "aliases": [], "types": ["T044"], "canonical_name": "type I restriction endodeoxyribonuclease inhibitor"}
{"concept_id": "C1818946", "aliases": [], "types": ["T044"], "canonical_name": "type I restriction enzyme inhibitor"}
{"concept_id": "C1818947", "aliases": ["down-regulation of type II restriction endodeoxyribonuclease activity", "downregulation of type II restriction endodeoxyribonuclease activity", "down regulation of type II restriction endodeoxyribonuclease activity", "negative regulation of type II restriction endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of type II site-specific deoxyribonuclease activity", "definition": "Any process that stops or reduces the rate of type II restriction endodeoxyribonuclease activity. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1818948", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of type II restriction endodeoxyribonuclease activity"}
{"concept_id": "C1818949", "aliases": [], "types": ["T044"], "canonical_name": "type II restriction endodeoxyribonuclease inhibitor"}
{"concept_id": "C1818950", "aliases": [], "types": ["T044"], "canonical_name": "type II restriction enzyme inhibitor"}
{"concept_id": "C1818951", "aliases": ["downregulation of type III restriction endodeoxyribonuclease activity", "down-regulation of type III restriction endodeoxyribonuclease activity", "negative regulation of type III restriction endodeoxyribonuclease activity", "down regulation of type III restriction endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of type III site-specific deoxyribonuclease activity", "definition": "Any process that stops or reduces the rate of type III restriction endodeoxyribonuclease activity. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1818952", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of type III restriction endodeoxyribonuclease activity"}
{"concept_id": "C1818953", "aliases": [], "types": ["T044"], "canonical_name": "type III restriction endodeoxyribonuclease inhibitor"}
{"concept_id": "C1818954", "aliases": [], "types": ["T044"], "canonical_name": "type III restriction enzyme inhibitor"}
{"concept_id": "C1818955", "aliases": ["down regulation of type IV restriction endodeoxyribonuclease activity", "down-regulation of type IV restriction endodeoxyribonuclease activity", "downregulation of type IV restriction endodeoxyribonuclease activity", "negative regulation of type IV restriction endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of type IV site-specific deoxyribonuclease activity", "definition": "Any process that stops or reduces the rate of type IV restriction endodeoxyribonuclease activity. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1818956", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of type IV restriction endodeoxyribonuclease activity"}
{"concept_id": "C1818957", "aliases": [], "types": ["T044"], "canonical_name": "type IV restriction endodeoxyribonuclease inhibitor"}
{"concept_id": "C1818958", "aliases": [], "types": ["T044"], "canonical_name": "type IV restriction enzyme inhibitor"}
{"concept_id": "C1818959", "aliases": ["regulation of type I restriction endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "regulation of type I site-specific deoxyribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of a type I restriction endodeoxyribonuclease activity. [GOC:dph, GOC:mah]"}
{"concept_id": "C1818960", "aliases": [], "types": ["T044"], "canonical_name": "type I restriction endodeoxyribonuclease regulator"}
{"concept_id": "C1818961", "aliases": [], "types": ["T044"], "canonical_name": "type I restriction enzyme regulator"}
{"concept_id": "C1818962", "aliases": ["regulation of type II restriction endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "regulation of type II site-specific deoxyribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of a type II restriction endodeoxyribonuclease activity. [GOC:dph, GOC:mah]"}
{"concept_id": "C1818963", "aliases": [], "types": ["T044"], "canonical_name": "type II restriction endodeoxyribonuclease regulator"}
{"concept_id": "C1818964", "aliases": [], "types": ["T044"], "canonical_name": "type II restriction enzyme regulator"}
{"concept_id": "C1818966", "aliases": [], "types": ["T044"], "canonical_name": "type III restriction endodeoxyribonuclease regulator"}
{"concept_id": "C1818967", "aliases": [], "types": ["T044"], "canonical_name": "type III restriction enzyme regulator"}
{"concept_id": "C1818968", "aliases": ["regulation of type IV restriction endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "regulation of type IV site-specific deoxyribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of a type IV restriction endodeoxyribonuclease activity. [GOC:mah]"}
{"concept_id": "C1818969", "aliases": [], "types": ["T044"], "canonical_name": "type IV restriction endodeoxyribonuclease regulator"}
{"concept_id": "C1818970", "aliases": [], "types": ["T044"], "canonical_name": "type IV restriction enzyme regulator"}
{"concept_id": "C1818971", "aliases": ["inhibition of NF-kappaB transcription factor"], "types": ["T043"], "canonical_name": "negative regulation of NF-kappaB transcription factor activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. [GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C1818972", "aliases": [], "types": ["T043"], "canonical_name": "NF-kappaB inhibitor"}
{"concept_id": "C1818973", "aliases": [], "types": ["T044"], "canonical_name": "NACHT domain binding", "definition": "Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs. [GOC:rl]"}
{"concept_id": "C1818974", "aliases": ["DAPIN domain binding", "PAAD domain binding"], "types": ["T044"], "canonical_name": "Pyrin domain binding", "definition": "Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain. [GOC:rl]"}
{"concept_id": "C1818975", "aliases": ["down regulation of protein binding", "down-regulation of protein binding", "downregulation of protein binding"], "types": ["T044"], "canonical_name": "negative regulation of protein binding", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. [GOC:mah]"}
{"concept_id": "C1818976", "aliases": ["up regulation of protein binding", "up-regulation of protein binding", "upregulation of protein binding"], "types": ["T044"], "canonical_name": "positive regulation of protein binding", "definition": "Any process that activates or increases the frequency, rate or extent of protein binding. [GOC:mah]"}
{"concept_id": "C1818977", "aliases": ["Sterile Alpha Motif domain binding"], "types": ["T044"], "canonical_name": "SAM domain binding", "definition": "Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes. [GOC:mcc, PMID:16337230]"}
{"concept_id": "C1818978", "aliases": [], "types": ["T043"], "canonical_name": "response to food", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. [GOC:add, ISBN:0721601464]"}
{"concept_id": "C1818979", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to food", "definition": "Any process that modulates the frequency, rate or extent of a response to a food stimulus. [GOC:add]"}
{"concept_id": "C1818980", "aliases": ["down regulation of response to food", "downregulation of response to food", "down-regulation of response to food"], "types": ["T039"], "canonical_name": "negative regulation of response to food", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. [GOC:add]"}
{"concept_id": "C1818981", "aliases": ["upregulation of response to food", "up regulation of response to food", "up-regulation of response to food"], "types": ["T039"], "canonical_name": "positive regulation of response to food", "definition": "Any process that activates, maintains, or increases the rate of a response to a food stimulus. [GOC:add]"}
{"concept_id": "C1818982", "aliases": [], "types": ["T040"], "canonical_name": "regulation of hunger"}
{"concept_id": "C1818983", "aliases": ["negative regulation of hunger", "down regulation of appetite", "appetite suppression", "down-regulation of appetite", "negative regulation of appetite"], "types": ["T040"], "definition": "Any process that reduces appetite. [GOC:add]", "canonical_name": "downregulation of appetite"}
{"concept_id": "C1818984", "aliases": ["up-regulation of appetite", "up regulation of appetite", "upregulation of appetite"], "types": ["T040"], "canonical_name": "positive regulation of appetite", "definition": "Any process that increases appetite. [GOC:add]"}
{"concept_id": "C1818986", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of hunger"}
{"concept_id": "C1818987", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to external stimulus", "definition": "Any process that modulates the frequency, rate or extent of a response to an external stimulus. [GOC:mah]"}
{"concept_id": "C1818988", "aliases": ["down regulation of response to external stimulus", "downregulation of response to external stimulus", "down-regulation of response to external stimulus"], "types": ["T039"], "canonical_name": "negative regulation of response to external stimulus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. [GOC:mah]"}
{"concept_id": "C1818989", "aliases": ["up regulation of response to external stimulus", "upregulation of response to external stimulus", "up-regulation of response to external stimulus"], "types": ["T039"], "canonical_name": "positive regulation of response to external stimulus", "definition": "Any process that activates, maintains or increases the rate of a response to an external stimulus. [GOC:mah]"}
{"concept_id": "C1818990", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to extracellular stimulus", "definition": "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus. [GOC:mah]"}
{"concept_id": "C1818991", "aliases": ["downregulation of response to extracellular stimulus", "down-regulation of response to extracellular stimulus", "down regulation of response to extracellular stimulus"], "types": ["T039"], "canonical_name": "negative regulation of response to extracellular stimulus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus. [GOC:mah]"}
{"concept_id": "C1818992", "aliases": ["upregulation of response to extracellular stimulus", "up regulation of response to extracellular stimulus", "up-regulation of response to extracellular stimulus"], "types": ["T039"], "canonical_name": "positive regulation of response to extracellular stimulus", "definition": "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus. [GOC:mah]"}
{"concept_id": "C1818993", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to nutrient levels", "definition": "Any process that modulates the frequency, rate or extent of a response to nutrient levels. [GOC:mah]"}
{"concept_id": "C1818994", "aliases": ["down-regulation of response to nutrient levels", "downregulation of response to nutrient levels", "down regulation of response to nutrient levels"], "types": ["T039"], "canonical_name": "negative regulation of response to nutrient levels", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. [GOC:mah]"}
{"concept_id": "C1818995", "aliases": ["upregulation of response to nutrient levels", "up-regulation of response to nutrient levels", "up regulation of response to nutrient levels"], "types": ["T039"], "canonical_name": "positive regulation of response to nutrient levels", "definition": "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels. [GOC:mah]"}
{"concept_id": "C1818996", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein histidine kinase activity", "definition": "Any process that modulates the frequency, rate or extent of protein histidine kinase activity. [GOC:mah]"}
{"concept_id": "C1818997", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein histidine kinase activity", "definition": "Any process that initiates the activity of an inactive protein histidine kinase. [GOC:mah]"}
{"concept_id": "C1818998", "aliases": [], "types": ["T043"], "canonical_name": "protein histidine kinase activator"}
{"concept_id": "C1818999", "aliases": ["downregulation of protein histidine kinase activity", "down regulation of protein histidine kinase activity", "down-regulation of protein histidine kinase activity"], "types": ["T043"], "canonical_name": "negative regulation of protein histidine kinase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity. [GOC:mah]"}
{"concept_id": "C1819000", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein histidine kinase activity"}
{"concept_id": "C1819001", "aliases": [], "types": ["T043"], "canonical_name": "protein histidine kinase inhibitor"}
{"concept_id": "C1819002", "aliases": [], "types": ["T044"], "canonical_name": "regulation of carbohydrate phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate. [GOC:mah]"}
{"concept_id": "C1819003", "aliases": [], "types": ["T044"], "canonical_name": "regulation of glucose-6-phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate. [GOC:kp]"}
{"concept_id": "C1819004", "aliases": ["D-glucitol:NADP+ oxidoreductase activity", "Sou1p"], "types": ["T044"], "canonical_name": "sorbose reductase activity", "definition": "Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction. [EC:1.1.1.289, RHEA:14609]"}
{"concept_id": "C1819005", "aliases": ["cohesin loading complex location"], "types": ["T026"], "canonical_name": "cohesin loading complex"}
{"concept_id": "C1819006", "aliases": ["horsetail-astral microtubule organisation", "horsetail-astral microtubule organization and biogenesis", "horsetail-astral microtubule array organization"], "types": ["T043"], "canonical_name": "horsetail-astral microtubule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis. [GOC:mah]"}
{"concept_id": "C1819007", "aliases": [], "types": ["T038"], "canonical_name": "sequestering of zinc ion", "definition": "The process of binding or confining zinc ions such that they are separated from other components of a biological system. [GOC:mah]"}
{"concept_id": "C1819008", "aliases": ["forespore membrane biosynthesis", "FSM assembly", "FSM formation", "ascospore-type prospore membrane assembly", "FSM biosynthesis", "forespore membrane formation"], "types": ["T043"], "canonical_name": "ascospore-type prospore membrane formation", "definition": "The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed. [GOC:clt, PMID:27630265]"}
{"concept_id": "C1819009", "aliases": [], "types": ["T043"], "canonical_name": "attachment of telomeres to spindle pole body"}
{"concept_id": "C1819010", "aliases": ["oral apparatus organization and biogenesis", "oral apparatus organisation"], "types": ["T043"], "canonical_name": "oral apparatus organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans. [PMID:10503189, PMID:6414830]"}
{"concept_id": "C1819011", "aliases": [], "types": ["T043"], "canonical_name": "oral apparatus morphogenesis"}
{"concept_id": "C1819012", "aliases": [], "types": ["T043"], "canonical_name": "stomatogenesis"}
{"concept_id": "C1819013", "aliases": ["deep fibre"], "types": ["T026"], "canonical_name": "deep fiber", "definition": "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm. [PMID:10503189]"}
{"concept_id": "C1819014", "aliases": ["macronuclear organization and biogenesis", "macronucleus organisation", "macronuclear organization"], "types": ["T043"], "canonical_name": "macronucleus organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus. [GOC:dph, GOC:jl, GOC:mah, PMID:10503190]"}
{"concept_id": "C1819015", "aliases": ["micronucleus organisation", "micronuclear organization and biogenesis", "micronuclear organization"], "types": ["T043"], "canonical_name": "micronucleus organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus. [GOC:dph, GOC:jl, GOC:mah, PMID:10503190]"}
{"concept_id": "C1819016", "aliases": [], "types": ["T026"], "canonical_name": "eisosome", "definition": "A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization. [GOC:al, GOC:vw, PMID:16496001, PMID:22368779]"}
{"concept_id": "C1819017", "aliases": ["dense core vesicle membrane"], "types": ["T026"], "canonical_name": "dense core granule membrane", "definition": "The lipid bilayer surrounding a dense core granule. [GOC:mah]"}
{"concept_id": "C1819018", "aliases": [], "types": ["T043"], "canonical_name": "flocculation via extracellular polymer"}
{"concept_id": "C1819019", "aliases": [], "types": ["T044"], "canonical_name": "histone deacetylase activity (H3-K9 specific)", "definition": "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. [PMID:28450737]"}
{"concept_id": "C1819020", "aliases": [], "types": ["T043"], "canonical_name": "medial membrane band formation"}
{"concept_id": "C1819021", "aliases": [], "types": ["T045"], "canonical_name": "alkylated DNA binding", "definition": "Binding to an alkylated residue in DNA. [GOC:mah]"}
{"concept_id": "C1819022", "aliases": [], "types": ["T045"], "canonical_name": "O6-alkylguanine-DNA binding", "definition": "Binding to an O6-alkylguanine adduct in DNA. [GOC:mah, PMID:16679453]"}
{"concept_id": "C1819023", "aliases": ["chromosome passenger complex location", "chromosomal passenger complex location", "CPC", "CPC complex location", "chromosomal passenger complex", "CPC complex"], "types": ["T026"], "definition": "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin. [GOC:vw, PMID:16824200, PMID:19570910]", "canonical_name": "chromosome passenger complex"}
{"concept_id": "C1819025", "aliases": ["insertion binding"], "types": ["T045"], "canonical_name": "DNA insertion or deletion binding", "definition": "Binding to a double-stranded DNA region containing an insertion or a deletion. [GOC:vk]"}
{"concept_id": "C1819026", "aliases": [], "types": ["T045"], "canonical_name": "DNA insertion binding"}
{"concept_id": "C1819027", "aliases": ["A/C mispair binding", "cytosine/adenine mispair binding", "C/A mispair binding"], "types": ["T045"], "canonical_name": "adenine/cytosine mispair binding", "definition": "Binding to a double-stranded DNA region containing an A/C mispair. [GOC:vk]"}
{"concept_id": "C1819028", "aliases": ["T/G mispair binding", "thymine/guanine mispair binding", "G/T mispair binding"], "types": ["T045"], "canonical_name": "guanine/thymine mispair binding", "definition": "Binding to a double-stranded DNA region containing a G/T mispair. [GOC:vk]"}
{"concept_id": "C1819029", "aliases": [], "types": ["T045"], "canonical_name": "single base insertion or deletion binding", "definition": "Binding to a double-stranded DNA region containing a single base insertion or deletion. [GOC:vk]"}
{"concept_id": "C1819030", "aliases": [], "types": ["T045"], "canonical_name": "single base insertion binding"}
{"concept_id": "C1819031", "aliases": [], "types": ["T045"], "canonical_name": "dinucleotide insertion or deletion binding", "definition": "Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion. [GOC:vk]"}
{"concept_id": "C1819032", "aliases": [], "types": ["T045"], "canonical_name": "dinucleotide insertion binding"}
{"concept_id": "C1819033", "aliases": [], "types": ["T045"], "canonical_name": "single adenine insertion binding", "definition": "Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine. [GOC:mah, GOC:vk]"}
{"concept_id": "C1819034", "aliases": [], "types": ["T045"], "canonical_name": "single cytosine insertion binding", "definition": "Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine. [GOC:mah, GOC:vk]"}
{"concept_id": "C1819035", "aliases": [], "types": ["T045"], "canonical_name": "single guanine insertion binding", "definition": "Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine. [GOC:mah, GOC:vk]"}
{"concept_id": "C1819036", "aliases": [], "types": ["T045"], "canonical_name": "single thymine insertion binding", "definition": "Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine. [GOC:mah, GOC:vk]"}
{"concept_id": "C1819037", "aliases": ["GABA transaminase complex", "GABA-T complex location", "4-aminobutyrate transaminase complex location", "ABAT complex location", "GABA-T complex", "ABAT complex", "GABA transaminase complex location"], "types": ["T026"], "canonical_name": "4-aminobutyrate transaminase complex", "definition": "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity. [GOC:mah, PMID:15528998]"}
{"concept_id": "C1819038", "aliases": ["succinic semialdehyde dehydrogenase binding"], "types": ["T044"], "canonical_name": "succinate-semialdehyde dehydrogenase binding", "definition": "Binding to succinate-semialdehyde dehydrogenase. [GOC:mah]"}
{"concept_id": "C1819040", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein kinase activity", "definition": "Any process that initiates the activity of an inactive protein kinase. [GOC:mah]"}
{"concept_id": "C1819041", "aliases": [], "types": ["T043"], "canonical_name": "protein kinase activation"}
{"concept_id": "C1819042", "aliases": ["protein kinase B activation"], "types": ["T043"], "canonical_name": "activation of protein kinase B activity", "definition": "Any process that initiates the activity of the inactive enzyme protein kinase B. [GOC:pg]"}
{"concept_id": "C1819043", "aliases": ["response to rhamnose stimulus"], "types": ["T043"], "canonical_name": "response to rhamnose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus. [GOC:mlg]"}
{"concept_id": "C1819044", "aliases": [], "types": ["T043"], "canonical_name": "response to L-rhamnose stimulus"}
{"concept_id": "C1819045", "aliases": [], "types": ["T044"], "canonical_name": "ubiquinone biosynthetic process from chorismate", "definition": "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate. [GOC:mah, PMID:11583838]"}
{"concept_id": "C1819046", "aliases": ["mitotic septin complex location"], "types": ["T026"], "canonical_name": "mitotic septin complex", "definition": "A heterooligomeric septin complex that acts during mitotic cell division. [GOC:krc, PMID:16009555]"}
{"concept_id": "C1819047", "aliases": ["meiotic septin complex location"], "types": ["T026"], "canonical_name": "meiotic septin complex", "definition": "A heterooligomeric septin complex that acts during meiotic cell division. [GOC:krc, PMID:16009555]"}
{"concept_id": "C1819048", "aliases": ["cell division plane"], "types": ["T026"], "canonical_name": "cell division site", "definition": "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]"}
{"concept_id": "C1819049", "aliases": [], "types": ["T026"], "canonical_name": "cleavage furrow", "definition": "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm. [GOC:vw, ISBN:0805319409]"}
{"concept_id": "C1819051", "aliases": [], "types": ["T026"], "canonical_name": "septin cytoskeleton", "definition": "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes. [GOC:mah]"}
{"concept_id": "C1819052", "aliases": ["prospore contractile ring"], "types": ["T026"], "definition": "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis. [GOC:krc, PMID:16009555]", "canonical_name": "actomyosin ring"}
{"concept_id": "C1819053", "aliases": [], "types": ["T026"], "canonical_name": "meiotic contractile ring"}
{"concept_id": "C1819054", "aliases": [], "types": ["T026"], "canonical_name": "septin band", "definition": "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously. [GOC:krc, PMID:16151244]"}
{"concept_id": "C1819055", "aliases": [], "types": ["T026"], "canonical_name": "septin cap", "definition": "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. [GOC:krc, PMID:16151244]"}
{"concept_id": "C1819056", "aliases": [], "types": ["T026"], "canonical_name": "septin filament array", "definition": "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans. [GOC:krc, PMID:16151244]"}
{"concept_id": "C1819057", "aliases": [], "types": ["T026"], "canonical_name": "septin bar"}
{"concept_id": "C1819058", "aliases": [], "types": ["T026"], "canonical_name": "cleavage apparatus septin structure", "definition": "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis. [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555]"}
{"concept_id": "C1819059", "aliases": [], "types": ["T026"], "canonical_name": "mating projection septin band", "definition": "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection). [GOC:krc, GOC:mah, PMID:16151244]"}
{"concept_id": "C1819060", "aliases": [], "types": ["T026"], "canonical_name": "hyphal septin band", "definition": "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously. [GOC:krc, GOC:mah, PMID:16151244]"}
{"concept_id": "C1819061", "aliases": [], "types": ["T026"], "canonical_name": "hyphal septin cap", "definition": "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. [GOC:krc, PMID:16151244]"}
{"concept_id": "C1819062", "aliases": [], "types": ["T026"], "canonical_name": "prospore septin filament array", "definition": "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation. [GOC:krc, PMID:16151244]"}
{"concept_id": "C1819063", "aliases": [], "types": ["T026"], "canonical_name": "chlamydospore septin filament array", "definition": "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation. [GOC:krc, PMID:16151244]"}
{"concept_id": "C1819065", "aliases": [], "types": ["T026"], "canonical_name": "hyphal septin ring", "definition": "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins. [GOC:krc, GOC:mah, PMID:16151244]"}
{"concept_id": "C1819066", "aliases": [], "types": ["T026"], "canonical_name": "prospore septin ring", "definition": "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins. [GOC:krc, GOC:mah, PMID:16151244]"}
{"concept_id": "C1819067", "aliases": [], "types": ["T026"], "canonical_name": "pseudohyphal septin ring", "definition": "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins. [GOC:krc, GOC:mah, PMID:16151244]"}
{"concept_id": "C1819068", "aliases": [], "types": ["T026"], "canonical_name": "germ tube septin cap", "definition": "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. [GOC:krc, PMID:16151244]"}
{"concept_id": "C1819069", "aliases": [], "types": ["T026"], "canonical_name": "germ tube septin ring", "definition": "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins. [GOC:krc, PMID:16151244]"}
{"concept_id": "C1819070", "aliases": ["septin hourglass"], "types": ["T026"], "canonical_name": "septin collar", "definition": "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell. [GOC:krc, PMID:16009555, PMID:16151244]"}
{"concept_id": "C1819072", "aliases": [], "types": ["T026"], "canonical_name": "mating projection septin ring", "definition": "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip. [GOC:krc, GOC:mah, PMID:16151244]"}
{"concept_id": "C1819073", "aliases": [], "types": ["T026"], "canonical_name": "split septin rings", "definition": "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well. [GOC:krc, PMID:16009555, PMID:16151244]"}
{"concept_id": "C1819075", "aliases": [], "types": ["T026"], "canonical_name": "medial membrane band", "definition": "A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum. [PMID:15517003]"}
{"concept_id": "C1819076", "aliases": [], "types": ["T026"], "canonical_name": "sterol-rich membrane band"}
{"concept_id": "C1819077", "aliases": [], "types": ["T026"], "canonical_name": "germ tube", "definition": "The slender tubular outgrowth first produced by most spores in germination. [ISBN:0877799148]"}
{"concept_id": "C1819078", "aliases": [], "types": ["T044"], "canonical_name": "ubiquinone biosynthetic process from tyrosine", "definition": "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate. [GOC:mah, PMID:11583838]"}
{"concept_id": "C1819079", "aliases": [], "types": ["T045"], "canonical_name": "dinucleotide repeat insertion binding", "definition": "Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats. [GOC:mah, GOC:vk]"}
{"concept_id": "C1819080", "aliases": ["small conjugating protein binding"], "types": ["T044"], "canonical_name": "ubiquitin-like protein binding", "definition": "Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein. [GOC:mah]"}
{"concept_id": "C1819081", "aliases": [], "types": ["T044"], "canonical_name": "SUMO binding", "definition": "Binding to the small ubiquitin-like protein SUMO. [GOC:mah]"}
{"concept_id": "C1819082", "aliases": [], "types": ["T044"], "canonical_name": "Smt3 binding"}
{"concept_id": "C1819083", "aliases": [], "types": ["T044"], "canonical_name": "Smt3 monomer binding"}
{"concept_id": "C1819084", "aliases": ["Smt3 polymer binding"], "types": ["T044"], "canonical_name": "SUMO polymer binding", "definition": "Binding to a polymer of the small ubiquitin-like protein SUMO. [GOC:mah]"}
{"concept_id": "C1819085", "aliases": ["septin cytoskeleton organization and biogenesis", "septin cytoskeleton organisation"], "types": ["T043"], "canonical_name": "septin cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1819090", "aliases": [], "types": ["T043"], "canonical_name": "cytokinetic ring anchoring"}
{"concept_id": "C1819091", "aliases": [], "types": ["T044"], "canonical_name": "acrosin binding", "definition": "Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. [GOC:mah, PMID:12398221]"}
{"concept_id": "C1819094", "aliases": [], "types": ["T044"], "canonical_name": "ubiquinone biosynthetic process via 2-polyprenylphenol", "definition": "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol. [GOC:mah, PMID:11583838]"}
{"concept_id": "C1819095", "aliases": [], "types": ["T044"], "canonical_name": "ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate", "definition": "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate. [GOC:mah, PMID:11583838]"}
{"concept_id": "C1819096", "aliases": ["post-lysosome", "postlysosome"], "types": ["T026"], "canonical_name": "post-lysosomal vacuole", "definition": "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis. [GOC:pf, PMID:23494323, PMID:9276759, PMID:9394012]"}
{"concept_id": "C1819097", "aliases": [], "types": ["T045"], "canonical_name": "Tf transposition"}
{"concept_id": "C1819098", "aliases": ["Class III transposition"], "types": ["T061"], "canonical_name": "MITE transposition", "definition": "Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs). [GOC:jp, ISBN:1555812090]"}
{"concept_id": "C1819099", "aliases": ["reverse transcription during retrotransposition"], "types": ["T045"], "canonical_name": "reverse transcription involved in RNA-mediated transposition", "definition": "The synthesis of DNA from an RNA transposon intermediate. [GOC:jp, GOC:txnOH, ISBN:1555812090]"}
{"concept_id": "C1819100", "aliases": ["telomere organization and biogenesis", "chromosome organization, telomeric", "organization of chromosome, telomeric region", "telomere organisation"], "types": ["T043"], "canonical_name": "telomere organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1819101", "aliases": [], "types": ["T045"], "canonical_name": "telomere maintenance via semi-conservative replication", "definition": "The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication. [GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:vw, PMID:16598261]"}
{"concept_id": "C1819102", "aliases": [], "types": ["T045"], "canonical_name": "equal telomere replication"}
{"concept_id": "C1819103", "aliases": [], "types": ["T045"], "canonical_name": "telomeric fork progression"}
{"concept_id": "C1819104", "aliases": [], "types": ["T045"], "canonical_name": "telomeric replication fork progression"}
{"concept_id": "C1819105", "aliases": ["telomere formation"], "types": ["T043"], "canonical_name": "telomere assembly", "definition": "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins. [GOC:mah, GOC:ns, PMID:11902675, PMID:8622671]"}
{"concept_id": "C1819106", "aliases": [], "types": ["T043"], "canonical_name": "telomere formation via telomerase", "definition": "A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme. [GOC:cjm, GOC:ns, PMID:11902675, PMID:8622671]"}
{"concept_id": "C1819107", "aliases": [], "types": ["T045"], "canonical_name": "regulation of telomere maintenance", "definition": "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. [GOC:mah]"}
{"concept_id": "C1819108", "aliases": ["downregulation of telomere maintenance", "down regulation of telomere maintenance", "down-regulation of telomere maintenance"], "types": ["T045"], "canonical_name": "negative regulation of telomere maintenance", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. [GOC:mah]"}
{"concept_id": "C1819109", "aliases": ["upregulation of telomere maintenance", "up regulation of telomere maintenance", "up-regulation of telomere maintenance"], "types": ["T045"], "canonical_name": "positive regulation of telomere maintenance", "definition": "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. [GOC:mah]"}
{"concept_id": "C1819110", "aliases": [], "types": ["T045"], "canonical_name": "regulation of telomere maintenance via recombination", "definition": "Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. [GOC:mah]"}
{"concept_id": "C1819111", "aliases": ["down-regulation of telomere maintenance via recombination", "downregulation of telomere maintenance via recombination", "down regulation of telomere maintenance via recombination"], "types": ["T045"], "canonical_name": "negative regulation of telomere maintenance via recombination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. [GOC:mah]"}
{"concept_id": "C1819112", "aliases": ["up regulation of telomere maintenance via recombination", "up-regulation of telomere maintenance via recombination", "upregulation of telomere maintenance via recombination"], "types": ["T045"], "canonical_name": "positive regulation of telomere maintenance via recombination", "definition": "Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. [GOC:mah]"}
{"concept_id": "C1819113", "aliases": [], "types": ["T045"], "canonical_name": "regulation of telomere maintenance via telomerase", "definition": "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah]"}
{"concept_id": "C1819114", "aliases": ["down regulation of telomere maintenance via telomerase activity", "downregulation of telomere maintenance via telomerase activity", "down-regulation of telomere maintenance via telomerase activity"], "types": ["T045"], "canonical_name": "negative regulation of telomere maintenance via telomerase", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah]"}
{"concept_id": "C1819115", "aliases": ["up-regulation of telomere maintenance via telomerase activity", "up regulation of telomere maintenance via telomerase activity", "upregulation of telomere maintenance via telomerase activity"], "types": ["T045"], "canonical_name": "positive regulation of telomere maintenance via telomerase", "definition": "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah]"}
{"concept_id": "C1819116", "aliases": [], "types": ["T045"], "canonical_name": "regulation of telomere maintenance via semi-conservative replication", "definition": "Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA. [GOC:mah]"}
{"concept_id": "C1819117", "aliases": ["down regulation of telomere maintenance via semi-conservative replication", "downregulation of telomere maintenance via semi-conservative replication", "down-regulation of telomere maintenance via semi-conservative replication"], "types": ["T045"], "canonical_name": "negative regulation of telomere maintenance via semi-conservative replication", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA. [GOC:mah]"}
{"concept_id": "C1819118", "aliases": ["up regulation of telomere maintenance via semi-conservative replication", "upregulation of telomere maintenance via semi-conservative replication", "up-regulation of telomere maintenance via semi-conservative replication"], "types": ["T045"], "canonical_name": "positive regulation of telomere maintenance via semi-conservative replication", "definition": "Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA. [GOC:mah]"}
{"concept_id": "C1819119", "aliases": ["glucosaminyl-phosphotidylinositol O-acyltransferase activity"], "types": ["T044"], "canonical_name": "glucosaminyl-phosphatidylinositol O-acyltransferase activity", "definition": "Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA. [Reactome:R-HSA-162683]"}
{"concept_id": "C1819120", "aliases": [], "types": ["T044"], "canonical_name": "GPI-inositol acyltransferase"}
{"concept_id": "C1819121", "aliases": [], "types": ["T044"], "canonical_name": "riboflavin transporter activity"}
{"concept_id": "C1819122", "aliases": [], "types": ["T043"], "canonical_name": "riboflavin transport", "definition": "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. [GOC:rn, PMID:16204239]"}
{"concept_id": "C1819124", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane fusion during cytogamy"}
{"concept_id": "C1819126", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic transmission, cholinergic", "definition": "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. [GOC:mah]"}
{"concept_id": "C1819127", "aliases": ["down-regulation of synaptic transmission, cholinergic", "down regulation of synaptic transmission, cholinergic", "downregulation of synaptic transmission, cholinergic"], "types": ["T042"], "canonical_name": "negative regulation of synaptic transmission, cholinergic", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. [GOC:mah]"}
{"concept_id": "C1819128", "aliases": ["up-regulation of synaptic transmission, cholinergic", "up regulation of synaptic transmission, cholinergic", "upregulation of synaptic transmission, cholinergic"], "types": ["T042"], "canonical_name": "positive regulation of synaptic transmission, cholinergic", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. [GOC:mah]"}
{"concept_id": "C1819129", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic transmission, dopaminergic", "definition": "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. [GOC:mah]"}
{"concept_id": "C1819130", "aliases": ["up regulation of synaptic transmission, dopaminergic", "up-regulation of synaptic transmission, dopaminergic", "upregulation of synaptic transmission, dopaminergic"], "types": ["T042"], "canonical_name": "positive regulation of synaptic transmission, dopaminergic", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. [GOC:mah]"}
{"concept_id": "C1819131", "aliases": ["down regulation of synaptic transmission, dopaminergic", "down-regulation of synaptic transmission, dopaminergic", "downregulation of synaptic transmission, dopaminergic"], "types": ["T042"], "canonical_name": "negative regulation of synaptic transmission, dopaminergic", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. [GOC:mah]"}
{"concept_id": "C1819132", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic transmission, GABAergic", "definition": "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]"}
{"concept_id": "C1819133", "aliases": ["down regulation of synaptic transmission, GABAergic", "downregulation of synaptic transmission, GABAergic", "down-regulation of synaptic transmission, GABAergic"], "types": ["T042"], "canonical_name": "negative regulation of synaptic transmission, GABAergic", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]"}
{"concept_id": "C1819134", "aliases": ["up regulation of synaptic transmission, GABAergic", "up-regulation of synaptic transmission, GABAergic", "upregulation of synaptic transmission, GABAergic"], "types": ["T042"], "canonical_name": "positive regulation of synaptic transmission, GABAergic", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]"}
{"concept_id": "C1819135", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament bundle formation"}
{"concept_id": "C1819141", "aliases": ["activation of store-operated calcium channel activity"], "types": ["T043"], "canonical_name": "activation of store-operated calcium channel activity", "definition": "A process that initiates the activity of an inactive store-operated calcium channel. [GOC:mah]"}
{"concept_id": "C1819142", "aliases": [], "types": ["T043"], "canonical_name": "adenosine transport", "definition": "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819144", "aliases": ["down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport", "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport", "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport", "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport"], "types": ["T044"], "canonical_name": "negative regulation of nucleobase-containing compound transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819145", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport"}
{"concept_id": "C1819146", "aliases": [], "types": ["T044"], "canonical_name": "regulation of nucleoside transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819147", "aliases": ["downregulation of nucleoside transport", "down regulation of nucleoside transport", "down-regulation of nucleoside transport"], "types": ["T044"], "canonical_name": "negative regulation of nucleoside transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819148", "aliases": ["up-regulation of nucleoside transport", "upregulation of nucleoside transport", "up regulation of nucleoside transport"], "types": ["T040"], "canonical_name": "positive regulation of nucleoside transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819149", "aliases": [], "types": ["T044"], "canonical_name": "regulation of purine nucleoside transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819150", "aliases": [], "types": ["T044"], "canonical_name": "regulation of pyrimidine nucleoside transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819151", "aliases": ["downregulation of purine nucleoside transport", "down regulation of purine nucleoside transport", "down-regulation of purine nucleoside transport"], "types": ["T044"], "canonical_name": "negative regulation of purine nucleoside transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819152", "aliases": ["upregulation of purine nucleoside transport", "up-regulation of purine nucleoside transport", "up regulation of purine nucleoside transport"], "types": ["T044"], "canonical_name": "positive regulation of purine nucleoside transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819153", "aliases": [], "types": ["T044"], "canonical_name": "regulation of adenosine transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819154", "aliases": ["downregulation of adenosine transport", "down-regulation of adenosine transport", "down regulation of adenosine transport"], "types": ["T044"], "canonical_name": "negative regulation of adenosine transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819155", "aliases": ["up regulation of adenosine transport", "up-regulation of adenosine transport", "upregulation of adenosine transport"], "types": ["T044"], "canonical_name": "positive regulation of adenosine transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819156", "aliases": ["secretory granule localisation"], "types": ["T038"], "canonical_name": "secretory granule localization", "definition": "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. [GOC:mah]"}
{"concept_id": "C1819157", "aliases": [], "types": ["T038"], "canonical_name": "secretory granule clustering"}
{"concept_id": "C1819158", "aliases": ["dense core vesicle localization", "dense core granule localisation"], "types": ["T038"], "canonical_name": "dense core granule localization", "definition": "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. [GOC:mah]"}
{"concept_id": "C1819159", "aliases": [], "types": ["T038"], "canonical_name": "dense core granule clustering"}
{"concept_id": "C1819160", "aliases": ["establishment of secretory granule localisation"], "types": ["T043"], "canonical_name": "establishment of secretory granule localization", "definition": "The directed movement of a secretory granule to a specific location. [GOC:mah]"}
{"concept_id": "C1819161", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of secretory granule localization"}
{"concept_id": "C1819162", "aliases": ["establishment of dense core granule localisation", "establishment of dense core vesicle localization"], "types": ["T043"], "canonical_name": "establishment of dense core granule localization", "definition": "The directed movement of a dense core granule to a specific location. [GOC:mah]"}
{"concept_id": "C1819163", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of dense core granule localization"}
{"concept_id": "C1819164", "aliases": ["cytoplasm-to-vacuole targeting", "cytoplasm to vacuole targeting"], "types": ["T043"], "canonical_name": "cytoplasm to vacuole targeting"}
{"concept_id": "C1819165", "aliases": [], "types": ["T043"], "canonical_name": "response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance"}
{"concept_id": "C1819166", "aliases": [], "types": ["T044"], "canonical_name": "purine nucleotide salvage", "definition": "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis. [GOC:jp]"}
{"concept_id": "C1819167", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine nucleotide salvage", "definition": "Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis. [GOC:mah]"}
{"concept_id": "C1819168", "aliases": [], "types": ["T044"], "canonical_name": "GMP salvage", "definition": "Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis. [GOC:mah]"}
{"concept_id": "C1819169", "aliases": [], "types": ["T044"], "canonical_name": "IMP salvage", "definition": "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis. [GOC:mah]"}
{"concept_id": "C1819170", "aliases": [], "types": ["T044"], "canonical_name": "XMP salvage", "definition": "Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis. [GOC:mah]"}
{"concept_id": "C1819171", "aliases": ["PtdIns-3-P binding", "phosphatidylinositol 3-phosphate binding"], "types": ["T044"], "canonical_name": "phosphatidylinositol-3-phosphate binding", "definition": "Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]"}
{"concept_id": "C1819173", "aliases": ["regulation of cellular protein metabolism"], "types": ["T044"], "canonical_name": "regulation of cellular protein metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. [GOC:mah]"}
{"concept_id": "C1819176", "aliases": ["regulation of protein polymerisation"], "types": ["T044"], "canonical_name": "regulation of protein polymerization", "definition": "Any process that modulates the frequency, rate or extent of the process of creating protein polymers. [GOC:mah]"}
{"concept_id": "C1819177", "aliases": ["down regulation of protein polymerization", "downregulation of protein polymerization", "down-regulation of protein polymerization"], "types": ["T044"], "canonical_name": "negative regulation of protein polymerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. [GOC:mah]"}
{"concept_id": "C1819178", "aliases": ["up-regulation of protein polymerization", "up regulation of protein polymerization", "upregulation of protein polymerization"], "types": ["T044"], "canonical_name": "positive regulation of protein polymerization", "definition": "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. [GOC:mah]"}
{"concept_id": "C1819179", "aliases": ["gonadotrophin secretion"], "types": ["T042"], "canonical_name": "gonadotropin secretion", "definition": "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone. [GOC:mah, ISBN:0721662544]"}
{"concept_id": "C1819180", "aliases": [], "types": ["T042"], "canonical_name": "luteinizing hormone secretion", "definition": "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. [ISBN:0198506732]"}
{"concept_id": "C1819181", "aliases": ["regulation of gonadotrophin secretion"], "types": ["T043"], "canonical_name": "regulation of gonadotropin secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. [GOC:mah]"}
{"concept_id": "C1819182", "aliases": ["down-regulation of gonadotropin secretion", "downregulation of gonadotropin secretion", "down regulation of gonadotropin secretion", "negative regulation of gonadotrophin secretion"], "types": ["T043"], "canonical_name": "negative regulation of gonadotropin secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin. [GOC:mah]"}
{"concept_id": "C1819183", "aliases": ["upregulation of gonadotropin secretion", "up regulation of gonadotropin secretion", "up-regulation of gonadotropin secretion", "positive regulation of gonadotrophin secretion"], "types": ["T043"], "canonical_name": "positive regulation of gonadotropin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin. [GOC:mah]"}
{"concept_id": "C1819185", "aliases": ["Gray's type II synapse"], "types": ["T030"], "canonical_name": "symmetric synapse", "definition": "A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory. [GOC:dgh, GOC:ef]"}
{"concept_id": "C1819186", "aliases": ["AMPA-selective glutamate receptor complex location", "alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex", "AMPA glutamate receptor complex location", "alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex location", "AMPA-selective glutamate receptor complex"], "types": ["T026"], "canonical_name": "AMPA glutamate receptor complex", "definition": "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. [GOC:ef]"}
{"concept_id": "C1819187", "aliases": [], "types": ["T026"], "canonical_name": "AMPA receptor"}
{"concept_id": "C1819188", "aliases": ["plastid ACCase complex location", "plastid acetyl-CoA carboxylase complex location", "plastid ACCase complex"], "types": ["T026"], "canonical_name": "plastid acetyl-CoA carboxylase complex", "definition": "An acetyl-CoA carboxylase complex located in the stroma of a plastid. [GOC:mah]"}
{"concept_id": "C1819189", "aliases": ["plastid acetate CoA-transferase complex location"], "types": ["T026"], "canonical_name": "plastid acetate CoA-transferase complex", "definition": "An acetate CoA-transferase complex located in the stroma of a plastid. [GOC:mah]"}
{"concept_id": "C1819190", "aliases": ["plastid biotin carboxylase complex location"], "types": ["T026"], "canonical_name": "plastid biotin carboxylase complex", "definition": "A biotin carboxylase complex located in the stroma of a plastid. [GOC:mah]"}
{"concept_id": "C1819191", "aliases": ["ensheathment of non-myelinated axons"], "types": ["T043"], "canonical_name": "non-myelinated axon ensheathment", "definition": "The process in which a non-myelinating glial cell membrane closes around an axon. [GOC:dgh]"}
{"concept_id": "C1819192", "aliases": ["myelin maintenance in central nervous system"], "types": ["T042"], "canonical_name": "central nervous system myelin maintenance", "definition": "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state. [GOC:dgh]"}
{"concept_id": "C1819193", "aliases": ["myelin maintenance in peripheral nervous system"], "types": ["T042"], "canonical_name": "peripheral nervous system myelin maintenance", "definition": "The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state. [GOC:dgh]"}
{"concept_id": "C1819194", "aliases": [], "types": ["T040"], "canonical_name": "myelin formation"}
{"concept_id": "C1819195", "aliases": ["myelin formation in central nervous system"], "types": ["T043"], "canonical_name": "central nervous system myelin formation", "definition": "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system. [GOC:dgh]"}
{"concept_id": "C1819196", "aliases": ["myelin formation in peripheral nervous system"], "types": ["T043"], "canonical_name": "peripheral nervous system myelin formation", "definition": "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system. [GOC:dgh]"}
{"concept_id": "C1819197", "aliases": ["ensheathment of axons in central nervous system"], "types": ["T043"], "canonical_name": "axon ensheathment in central nervous system", "definition": "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. [GOC:dgh]"}
{"concept_id": "C1819198", "aliases": ["ensheathment of axons in peripheral nervous system"], "types": ["T043"], "canonical_name": "peripheral nervous system axon ensheathment", "definition": "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. [GOC:dgh]"}
{"concept_id": "C1819199", "aliases": ["ensheathment of non-myelinated axons in central nervous system"], "types": ["T043"], "canonical_name": "non-myelinated axon ensheathment in central nervous system", "definition": "The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system. [GOC:dgh]"}
{"concept_id": "C1819200", "aliases": ["ensheathment of non-myelinated axons in peripheral nervous system"], "types": ["T043"], "canonical_name": "peripheral nervous system non-myelinated axon ensheathment", "definition": "The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons. [GOC:dgh]"}
{"concept_id": "C1819201", "aliases": [], "types": ["T043"], "canonical_name": "ensheathment of neuronal cell bodies", "definition": "The process in which satellite glial cells isolate neuronal cell bodies. [GOC:dgh]"}
{"concept_id": "C1819202", "aliases": ["dsRNA-specific RNase activity", "double-stranded RNA-specific RNase activity", "dsRNA-specific ribonuclease activity"], "types": ["T045"], "canonical_name": "double-stranded RNA-specific ribonuclease activity", "definition": "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules. [GOC:mah]"}
{"concept_id": "C1819203", "aliases": ["down-regulation of DNA replication initiation", "down regulation of DNA replication initiation", "downregulation of DNA replication initiation", "negative regulation of DNA-dependent DNA replication initiation"], "types": ["T045"], "canonical_name": "negative regulation of DNA-templated DNA replication initiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication. [GOC:mah]"}
{"concept_id": "C1819204", "aliases": ["up-regulation of DNA replication initiation", "positive regulation of DNA-dependent DNA replication initiation", "up regulation of DNA replication initiation", "upregulation of DNA replication initiation"], "types": ["T045"], "canonical_name": "positive regulation of DNA-templated DNA replication initiation", "definition": "Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication. [GOC:mah]"}
{"concept_id": "C1819205", "aliases": ["RNase H2 complex", "ribonuclease H2 complex location", "RNase H2 complex location"], "types": ["T026"], "canonical_name": "ribonuclease H2 complex", "definition": "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p. [GOC:mah, PMID:14734815]"}
{"concept_id": "C1819206", "aliases": ["mismatch repair complex location"], "types": ["T026"], "canonical_name": "mismatch repair complex", "definition": "Any complex formed of proteins that act in mismatch repair. [GOC:mah]"}
{"concept_id": "C1819207", "aliases": ["MSH2/MSH6 complex location", "MSH2/MSH6 complex", "MutSalpha complex location"], "types": ["T026"], "canonical_name": "MutSalpha complex", "definition": "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6. [PMID:11005803]"}
{"concept_id": "C1819208", "aliases": ["MSH2/MSH3 complex", "MutSbeta complex location", "MSH2/MSH3 complex location"], "types": ["T026"], "canonical_name": "MutSbeta complex", "definition": "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. [PMID:11005803]"}
{"concept_id": "C1819209", "aliases": ["regulation of eicosanoid secretion"], "types": ["T043"], "canonical_name": "regulation of icosanoid secretion", "definition": "Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. [GOC:mah]"}
{"concept_id": "C1819210", "aliases": ["negative regulation of eicosanoid secretion", "downregulation of icosanoid secretion", "down-regulation of icosanoid secretion", "down regulation of icosanoid secretion"], "types": ["T043"], "canonical_name": "negative regulation of icosanoid secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell. [GOC:mah]"}
{"concept_id": "C1819211", "aliases": ["positive regulation of eicosanoid secretion", "up-regulation of icosanoid secretion", "up regulation of icosanoid secretion", "upregulation of icosanoid secretion"], "types": ["T043"], "canonical_name": "positive regulation of icosanoid secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell. [GOC:mah]"}
{"concept_id": "C1819212", "aliases": [], "types": ["T043"], "canonical_name": "regulation of prostaglandin secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell. [GOC:mah]"}
{"concept_id": "C1819213", "aliases": [], "types": ["T043"], "canonical_name": "regulation of prostacyclin secretion"}
{"concept_id": "C1819214", "aliases": ["down regulation of prostaglandin secretion", "down-regulation of prostaglandin secretion", "downregulation of prostaglandin secretion"], "types": ["T043"], "canonical_name": "negative regulation of prostaglandin secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell. [GOC:mah]"}
{"concept_id": "C1819215", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of prostacyclin secretion"}
{"concept_id": "C1819216", "aliases": ["up-regulation of prostaglandin secretion", "up regulation of prostaglandin secretion", "upregulation of prostaglandin secretion"], "types": ["T043"], "canonical_name": "positive regulation of prostaglandin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell. [GOC:mah]"}
{"concept_id": "C1819217", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of prostacyclin secretion"}
{"concept_id": "C1819218", "aliases": ["eicosanoid secretion"], "types": ["T043"], "canonical_name": "icosanoid secretion", "definition": "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue. [GOC:mah]"}
{"concept_id": "C1819219", "aliases": [], "types": ["T043"], "canonical_name": "prostaglandin secretion", "definition": "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue. [GOC:mah]"}
{"concept_id": "C1819220", "aliases": [], "types": ["T043"], "canonical_name": "prostacyclin secretion"}
{"concept_id": "C1819221", "aliases": ["angiogenin-PRI complex location", "angiogenin-placental ribonuclease inhibitor complex", "angiogenin-placental ribonuclease inhibitor complex location"], "types": ["T026"], "canonical_name": "angiogenin-PRI complex", "definition": "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis. [PMID:2706246, PMID:3470787]"}
{"concept_id": "C1819222", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ARF GTPase activity"}
{"concept_id": "C1819223", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Rab GTPase activity"}
{"concept_id": "C1819224", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Rac GTPase activity"}
{"concept_id": "C1819225", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Ral GTPase activity"}
{"concept_id": "C1819226", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Ran GTPase activity"}
{"concept_id": "C1819227", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Rap GTPase activity"}
{"concept_id": "C1819228", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Ras GTPase activity"}
{"concept_id": "C1819229", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Rho GTPase activity"}
{"concept_id": "C1819230", "aliases": ["upregulation of Ras GTPase activity", "up-regulation of Ras GTPase activity", "up regulation of Ras GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of Ras GTPase activity"}
{"concept_id": "C1819231", "aliases": ["up-regulation of Rho GTPase activity", "upregulation of Rho GTPase activity", "up regulation of Rho GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of Rho GTPase activity"}
{"concept_id": "C1819232", "aliases": ["ubiquinone breakdown", "ubiquinone catabolism", "ubiquinone degradation"], "types": ["T044"], "canonical_name": "ubiquinone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme. [GOC:mah]"}
{"concept_id": "C1819233", "aliases": ["lipoic acid breakdown", "lipoic acid degradation", "lipoic acid catabolism"], "types": ["T044"], "canonical_name": "lipoate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lipoate. [GOC:mah]"}
{"concept_id": "C1819234", "aliases": ["molybdopterin cofactor anabolism", "molybdopterin cofactor synthesis"], "types": ["T044"], "canonical_name": "molybdopterin cofactor biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. [GOC:mah]"}
{"concept_id": "C1819235", "aliases": ["molybdopterin cofactor formation"], "types": ["T044"], "canonical_name": "molybdopterin cofactor biosynthesis"}
{"concept_id": "C1819236", "aliases": [], "types": ["T044"], "canonical_name": "molybdopterin cofactor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. [GOC:mah]"}
{"concept_id": "C1819237", "aliases": ["Mo-molybdopterin cofactor catabolism", "Mo-molybdopterin cofactor breakdown", "Mo-molybdopterin cofactor degradation"], "types": ["T044"], "canonical_name": "Mo-molybdopterin cofactor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. [GOC:mah]"}
{"concept_id": "C1819238", "aliases": ["Moco catabolic process"], "types": ["T044"], "canonical_name": "Moco catabolic process"}
{"concept_id": "C1819239", "aliases": ["W-molybdopterin cofactor breakdown", "W-molybdopterin cofactor degradation", "W-molybdopterin cofactor catabolism"], "types": ["T044"], "canonical_name": "W-molybdopterin cofactor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. [GOC:mah]"}
{"concept_id": "C1819240", "aliases": ["Moco catabolism"], "types": ["T044"], "canonical_name": "Moco catabolism"}
{"concept_id": "C1819241", "aliases": [], "types": ["T043"], "canonical_name": "alanine transport", "definition": "The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819242", "aliases": [], "types": ["T043"], "canonical_name": "serine transport", "definition": "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819243", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chondrocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of chondrocyte differentiation. [GOC:mah]"}
{"concept_id": "C1819244", "aliases": ["down-regulation of chondrocyte differentiation", "down regulation of chondrocyte differentiation", "downregulation of chondrocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of chondrocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. [GOC:mah]"}
{"concept_id": "C1819245", "aliases": ["up regulation of chondrocyte differentiation", "up-regulation of chondrocyte differentiation", "upregulation of chondrocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of chondrocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. [GOC:mah]"}
{"concept_id": "C1819246", "aliases": [], "types": ["T042"], "canonical_name": "activin secretion", "definition": "The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone. [GOC:mah]"}
{"concept_id": "C1819247", "aliases": [], "types": ["T042"], "canonical_name": "inhibin secretion", "definition": "The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone. [GOC:mah]"}
{"concept_id": "C1819248", "aliases": [], "types": ["T043"], "canonical_name": "regulation of activin secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell. [GOC:mah]"}
{"concept_id": "C1819249", "aliases": ["down-regulation of activin secretion", "downregulation of activin secretion", "down regulation of activin secretion"], "types": ["T043"], "canonical_name": "negative regulation of activin secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell. [GOC:mah]"}
{"concept_id": "C1819250", "aliases": ["up regulation of activin secretion", "up-regulation of activin secretion", "upregulation of activin secretion"], "types": ["T043"], "canonical_name": "positive regulation of activin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell. [GOC:mah]"}
{"concept_id": "C1819251", "aliases": [], "types": ["T043"], "canonical_name": "regulation of inhibin secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell. [GOC:mah]"}
{"concept_id": "C1819252", "aliases": ["down-regulation of inhibin secretion", "down regulation of inhibin secretion", "downregulation of inhibin secretion"], "types": ["T043"], "canonical_name": "negative regulation of inhibin secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell. [GOC:mah]"}
{"concept_id": "C1819253", "aliases": ["upregulation of inhibin secretion", "up-regulation of inhibin secretion", "up regulation of inhibin secretion"], "types": ["T043"], "canonical_name": "positive regulation of inhibin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell. [GOC:mah]"}
{"concept_id": "C1819254", "aliases": ["aldosterone metabolism"], "types": ["T044"], "canonical_name": "aldosterone metabolic process", "definition": "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. [PMID:16527843]"}
{"concept_id": "C1819255", "aliases": [], "types": ["T044"], "canonical_name": "aldosterone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. [PMID:16527843]"}
{"concept_id": "C1819256", "aliases": [], "types": ["T044"], "canonical_name": "aldosterone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. [PMID:16527843]"}
{"concept_id": "C1819257", "aliases": ["regulation of aldosterone metabolism"], "types": ["T043"], "canonical_name": "regulation of aldosterone metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. [GOC:mah]"}
{"concept_id": "C1819258", "aliases": ["downregulation of aldosterone metabolic process", "down regulation of aldosterone metabolic process", "down-regulation of aldosterone metabolic process", "negative regulation of aldosterone metabolism"], "types": ["T043"], "canonical_name": "negative regulation of aldosterone metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. [GOC:mah]"}
{"concept_id": "C1819259", "aliases": ["upregulation of aldosterone metabolic process", "positive regulation of aldosterone metabolism", "up-regulation of aldosterone metabolic process", "up regulation of aldosterone metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of aldosterone metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. [GOC:mah]"}
{"concept_id": "C1819260", "aliases": [], "types": ["T043"], "canonical_name": "regulation of aldosterone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. [GOC:mah]"}
{"concept_id": "C1819261", "aliases": ["down regulation of aldosterone biosynthetic process", "downregulation of aldosterone biosynthetic process", "down-regulation of aldosterone biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of aldosterone biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. [GOC:mah]"}
{"concept_id": "C1819262", "aliases": ["up-regulation of aldosterone biosynthetic process", "upregulation of aldosterone biosynthetic process", "up regulation of aldosterone biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of aldosterone biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. [GOC:mah]"}
{"concept_id": "C1819263", "aliases": ["regulation of hormone metabolism"], "types": ["T043"], "canonical_name": "regulation of hormone metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. [GOC:mah]"}
{"concept_id": "C1819264", "aliases": ["negative regulation of hormone metabolism", "down-regulation of hormone metabolic process", "down regulation of hormone metabolic process", "downregulation of hormone metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of hormone metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone. [GOC:mah]"}
{"concept_id": "C1819265", "aliases": ["upregulation of hormone metabolic process", "up-regulation of hormone metabolic process", "up regulation of hormone metabolic process", "positive regulation of hormone metabolism"], "types": ["T044"], "canonical_name": "positive regulation of hormone metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. [GOC:mah]"}
{"concept_id": "C1819266", "aliases": ["downregulation of hormone biosynthetic process", "down-regulation of hormone biosynthetic process", "down regulation of hormone biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of hormone biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. [GOC:ai]"}
{"concept_id": "C1819267", "aliases": ["response to follicle-stimulating hormone stimulus", "response to FSH stimulus", "response to follicle stimulating hormone stimulus"], "types": ["T043"], "canonical_name": "response to follicle-stimulating hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. [GOC:mah]"}
{"concept_id": "C1819268", "aliases": ["response to E2 stimulus", "response to estradiol stimulus"], "types": ["T043"], "canonical_name": "response to estradiol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123]"}
{"concept_id": "C1819269", "aliases": ["oxidised DNA binding"], "types": ["T045"], "canonical_name": "oxidized DNA binding", "definition": "Binding to a DNA region containing an oxidized residue. [GOC:vk]"}
{"concept_id": "C1819270", "aliases": ["oxidized purine nucleobase DNA binding", "oxidized purine base DNA binding", "oxidised purine DNA binding"], "types": ["T045"], "canonical_name": "oxidized purine DNA binding", "definition": "Binding to a DNA region containing an oxidized purine residue. [GOC:vk]"}
{"concept_id": "C1819271", "aliases": ["oxidized pyrimidine nucleobase DNA binding", "oxidised pyrimidine DNA binding", "oxidized pyrimidine base DNA binding"], "types": ["T045"], "canonical_name": "oxidized pyrimidine DNA binding", "definition": "Binding to a DNA region containing an oxidized pyrimidine residue. [GOC:vk]"}
{"concept_id": "C1819273", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxal phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. [GOC:mah]"}
{"concept_id": "C1819275", "aliases": [], "types": ["T044"], "canonical_name": "FMN catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase. [GOC:mah]"}
{"concept_id": "C1819276", "aliases": [], "types": ["T038"], "canonical_name": "oxygen homeostasis", "definition": "A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell. [GOC:rph]"}
{"concept_id": "C1819277", "aliases": [], "types": ["T043"], "canonical_name": "intracellular lipid transport", "definition": "The directed movement of lipids within cells. [GOC:mah]"}
{"concept_id": "C1819278", "aliases": [], "types": ["T043"], "canonical_name": "intracellular sterol transport", "definition": "The directed movement of sterols within cells. [GOC:mah]"}
{"concept_id": "C1819279", "aliases": [], "types": ["T043"], "canonical_name": "intracellular cholesterol transport", "definition": "The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells. [GOC:mah]"}
{"concept_id": "C1819280", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lipid transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819281", "aliases": ["downregulation of lipid transport", "down regulation of lipid transport", "down-regulation of lipid transport"], "types": ["T044"], "canonical_name": "negative regulation of lipid transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819282", "aliases": ["up regulation of lipid transport", "upregulation of lipid transport", "up-regulation of lipid transport"], "types": ["T044"], "canonical_name": "positive regulation of lipid transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819283", "aliases": [], "types": ["T044"], "canonical_name": "regulation of sterol transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819284", "aliases": ["down-regulation of sterol transport", "down regulation of sterol transport", "downregulation of sterol transport"], "types": ["T044"], "canonical_name": "negative regulation of sterol transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819285", "aliases": ["upregulation of sterol transport", "up regulation of sterol transport", "up-regulation of sterol transport"], "types": ["T044"], "canonical_name": "positive regulation of sterol transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819286", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cholesterol transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819287", "aliases": ["downregulation of cholesterol transport", "down-regulation of cholesterol transport", "down regulation of cholesterol transport"], "types": ["T044"], "canonical_name": "negative regulation of cholesterol transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819288", "aliases": ["up regulation of cholesterol transport", "upregulation of cholesterol transport", "up-regulation of cholesterol transport"], "types": ["T044"], "canonical_name": "positive regulation of cholesterol transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C1819289", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intracellular lipid transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. [GOC:mah]"}
{"concept_id": "C1819290", "aliases": ["downregulation of intracellular lipid transport", "down-regulation of intracellular lipid transport", "down regulation of intracellular lipid transport"], "types": ["T043"], "canonical_name": "negative regulation of intracellular lipid transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. [GOC:mah]"}
{"concept_id": "C1819291", "aliases": ["upregulation of intracellular lipid transport", "up-regulation of intracellular lipid transport", "up regulation of intracellular lipid transport"], "types": ["T043"], "canonical_name": "positive regulation of intracellular lipid transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. [GOC:mah]"}
{"concept_id": "C1819292", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intracellular sterol transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells. [GOC:mah]"}
{"concept_id": "C1819293", "aliases": ["down-regulation of intracellular sterol transport", "down regulation of intracellular sterol transport", "downregulation of intracellular sterol transport"], "types": ["T043"], "canonical_name": "negative regulation of intracellular sterol transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells. [GOC:mah]"}
{"concept_id": "C1819294", "aliases": ["up-regulation of intracellular sterol transport", "up regulation of intracellular sterol transport", "upregulation of intracellular sterol transport"], "types": ["T043"], "canonical_name": "positive regulation of intracellular sterol transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells. [GOC:mah]"}
{"concept_id": "C1819295", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intracellular cholesterol transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells. [GOC:mah]"}
{"concept_id": "C1819296", "aliases": ["down-regulation of intracellular cholesterol transport", "downregulation of intracellular cholesterol transport", "down regulation of intracellular cholesterol transport"], "types": ["T043"], "canonical_name": "negative regulation of intracellular cholesterol transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells. [GOC:mah]"}
{"concept_id": "C1819297", "aliases": ["upregulation of intracellular cholesterol transport", "up-regulation of intracellular cholesterol transport", "up regulation of intracellular cholesterol transport"], "types": ["T043"], "canonical_name": "positive regulation of intracellular cholesterol transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells. [GOC:mah]"}
{"concept_id": "C1819298", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intracellular transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. [GOC:mah]"}
{"concept_id": "C1819299", "aliases": ["down regulation of intracellular transport", "downregulation of intracellular transport", "down-regulation of intracellular transport"], "types": ["T043"], "canonical_name": "negative regulation of intracellular transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. [GOC:mah]"}
{"concept_id": "C1819300", "aliases": ["upregulation of intracellular transport", "up regulation of intracellular transport", "up-regulation of intracellular transport"], "types": ["T043"], "canonical_name": "positive regulation of intracellular transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. [GOC:mah]"}
{"concept_id": "C1819301", "aliases": ["MutL-alpha complex", "MutL-alpha complex location", "MutLalpha complex location", "MLH1/PMS2 complex", "MLH1/PMS2 complex location"], "types": ["T026"], "canonical_name": "MutLalpha complex", "definition": "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. [GOC:vk]"}
{"concept_id": "C1819302", "aliases": ["MutLbeta complex location", "MLH1/PMS1 complex location", "MLH1/PMS1 complex"], "types": ["T026"], "canonical_name": "MutLbeta complex", "definition": "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1. [GOC:vk]"}
{"concept_id": "C1819303", "aliases": ["MMR complex", "MMR complex location"], "types": ["T026"], "canonical_name": "MMR complex"}
{"concept_id": "C1819304", "aliases": [], "types": ["T026"], "definition": "The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone. [GOC:cilia, PMID:15917207, PMID:22653444, PMID:8718680]", "canonical_name": "photoreceptor connecting cilium"}
{"concept_id": "C1819305", "aliases": ["photoreceptor cilium"], "types": ["T026"], "canonical_name": "photoreceptor cell cilium", "definition": "A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment. [GOC:cilia, Wikipedia:Photoreceptor_cell#Histology]"}
{"concept_id": "C1819306", "aliases": [], "types": ["T045"], "canonical_name": "DNA geometric change", "definition": "The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. [GOC:mah]"}
{"concept_id": "C1819307", "aliases": [], "types": ["T044"], "definition": "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149]", "canonical_name": "MHC class I receptor activity"}
{"concept_id": "C1819308", "aliases": [], "types": ["T044"], "canonical_name": "MHC class Ib receptor activity", "definition": "Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1819309", "aliases": [], "types": ["T044"], "canonical_name": "MHC class II receptor activity", "definition": "Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]"}
{"concept_id": "C1819310", "aliases": [], "types": ["T044"], "canonical_name": "inhibitory MHC class I receptor activity", "definition": "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte. [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134]"}
{"concept_id": "C1819311", "aliases": [], "types": ["T044"], "canonical_name": "activating MHC class I receptor activity", "definition": "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte. [GOC:add, PMID:11858820, PMID:9597134]"}
{"concept_id": "C1819312", "aliases": ["MHC class Ib protein complex location"], "types": ["T026"], "canonical_name": "MHC class Ib protein complex", "definition": "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. [GOC:add, ISBN:0781735149, PMID:15928678]"}
{"concept_id": "C1819313", "aliases": [], "types": ["T044"], "canonical_name": "HECT domain binding", "definition": "Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein. [GOC:mah, Pfam:PF00632]"}
{"concept_id": "C1819314", "aliases": ["melanosome localisation"], "types": ["T038"], "canonical_name": "melanosome localization", "definition": "Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell. [GOC:ln]"}
{"concept_id": "C1819315", "aliases": ["establishment of melanosome localisation"], "types": ["T043"], "canonical_name": "establishment of melanosome localization", "definition": "The directed movement of a melanosome to a specific location. [GOC:mah]"}
{"concept_id": "C1819316", "aliases": [], "types": ["T043"], "canonical_name": "melanosome transport", "definition": "The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ln]"}
{"concept_id": "C1819317", "aliases": ["protein complex binding"], "types": ["T044"], "canonical_name": "protein-containing complex binding", "definition": "Binding to a macromolecular complex. [GOC:jl]"}
{"concept_id": "C1819318", "aliases": [], "types": ["T044"], "canonical_name": "mismatch repair complex binding", "definition": "Binding to a mismatch repair complex. [GOC:vk]"}
{"concept_id": "C1819319", "aliases": [], "types": ["T044"], "canonical_name": "MutLalpha complex binding", "definition": "Binding to a MutLalpha mismatch repair complex. [GOC:vk]"}
{"concept_id": "C1819320", "aliases": [], "types": ["T044"], "canonical_name": "MutLbeta complex binding", "definition": "Binding to a MutLbeta mismatch repair complex. [GOC:vk]"}
{"concept_id": "C1819321", "aliases": [], "types": ["T044"], "canonical_name": "MutSalpha complex binding", "definition": "Binding to a MutSalpha mismatch repair complex. [GOC:vk]"}
{"concept_id": "C1819322", "aliases": [], "types": ["T044"], "canonical_name": "MutSbeta complex binding", "definition": "Binding to a MutSbeta mismatch repair complex. [GOC:vk]"}
{"concept_id": "C1819323", "aliases": [], "types": ["T038"], "canonical_name": "regulation of transporter activity", "definition": "Any process that modulates the activity of a transporter. [GOC:mah]"}
{"concept_id": "C1819324", "aliases": ["down regulation of transporter activity", "down-regulation of transporter activity", "downregulation of transporter activity"], "types": ["T039"], "canonical_name": "negative regulation of transporter activity", "definition": "Any process that stops or reduces the activity of a transporter. [GOC:mah]"}
{"concept_id": "C1819325", "aliases": ["up-regulation of transporter activity", "up regulation of transporter activity", "upregulation of transporter activity"], "types": ["T039"], "canonical_name": "positive regulation of transporter activity", "definition": "Any process that activates or increases the activity of a transporter. [GOC:mah]"}
{"concept_id": "C1819326", "aliases": ["regulation of ion transporter activity"], "types": ["T038"], "canonical_name": "regulation of ion transmembrane transporter activity", "definition": "Any process that modulates the activity of an ion transporter. [GOC:mah, GOC:tb]"}
{"concept_id": "C1819327", "aliases": ["downregulation of ion transporter activity", "down-regulation of ion transporter activity", "down regulation of ion transporter activity", "negative regulation of ion transporter activity"], "types": ["T038"], "canonical_name": "negative regulation of ion transmembrane transporter activity", "definition": "Any process that stops or reduces the activity of an ion transporter. [GOC:mah, GOC:tb]"}
{"concept_id": "C1819328", "aliases": ["up-regulation of ion transporter activity", "upregulation of ion transporter activity", "up regulation of ion transporter activity", "positive regulation of ion transporter activity"], "types": ["T038"], "canonical_name": "positive regulation of ion transmembrane transporter activity", "definition": "Any process that activates or increases the activity of an ion transporter. [GOC:mah, GOC:tb]"}
{"concept_id": "C1819329", "aliases": ["regulation of sodium:hydrogen antiporter activity"], "types": ["T038"], "canonical_name": "regulation of sodium:proton antiporter activity", "definition": "Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). [GOC:mah, GOC:mtg_transport]"}
{"concept_id": "C1819330", "aliases": ["down regulation of sodium:hydrogen antiporter activity", "down-regulation of sodium:hydrogen antiporter activity", "downregulation of sodium:hydrogen antiporter activity", "negative regulation of sodium:hydrogen antiporter activity"], "types": ["T039"], "canonical_name": "negative regulation of sodium:proton antiporter activity", "definition": "Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). [GOC:mah]"}
{"concept_id": "C1819331", "aliases": ["up regulation of sodium:hydrogen antiporter activity", "upregulation of sodium:hydrogen antiporter activity", "up-regulation of sodium:hydrogen antiporter activity", "positive regulation of sodium:hydrogen antiporter activity"], "types": ["T039"], "canonical_name": "positive regulation of sodium:proton antiporter activity", "definition": "Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). [GOC:mah]"}
{"concept_id": "C1819332", "aliases": ["lysosome localisation"], "types": ["T038"], "canonical_name": "lysosome localization", "definition": "Any process in which a lysosome is transported to, and/or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C1819333", "aliases": ["extrinsic to lysosomal membrane", "extrinsic to lysosome membrane"], "types": ["T026"], "canonical_name": "extrinsic component of lysosome membrane", "definition": "The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]"}
{"concept_id": "C1819334", "aliases": ["stereocilia bundle"], "types": ["T026"], "canonical_name": "stereocilium bundle", "definition": "A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. [GOC:ecd, PMID:15661519, PMID:7840137]"}
{"concept_id": "C1819335", "aliases": [], "types": ["T045"], "canonical_name": "purine-rich negative regulatory element binding", "definition": "Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes. [GOC:mah, PMID:9819411]"}
{"concept_id": "C1819336", "aliases": [], "types": ["T045"], "canonical_name": "PNR element binding"}
{"concept_id": "C1819337", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mismatch repair", "definition": "Any process that modulates the frequency, rate or extent of mismatch repair. [GOC:vk]"}
{"concept_id": "C1819338", "aliases": ["down regulation of mismatch repair", "downregulation of mismatch repair", "down-regulation of mismatch repair"], "types": ["T045"], "canonical_name": "negative regulation of mismatch repair", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair. [GOC:vk]"}
{"concept_id": "C1819339", "aliases": ["up-regulation of mismatch repair", "up regulation of mismatch repair", "upregulation of mismatch repair"], "types": ["T045"], "canonical_name": "positive regulation of mismatch repair", "definition": "Any process that activates or increases the frequency, rate or extent of mismatch repair. [GOC:vk]"}
{"concept_id": "C1819341", "aliases": [], "types": ["T026"], "canonical_name": "stereocilium tip", "definition": "A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation. [GOC:ecd, GOC:krc, PMID:17021180, PMID:27565685]"}
{"concept_id": "C1819342", "aliases": ["CRIB motif binding", "Cdc42/Rac interactive binding motif binding", "PMD binding", "P21-Rho-binding domain binding"], "types": ["T044"], "canonical_name": "GBD domain binding", "definition": "Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac. [GOC:mah, GOC:pg, PMID:9119069]"}
{"concept_id": "C1819343", "aliases": [], "types": ["T044"], "canonical_name": "beta-N-acetylgalactosaminidase activity", "definition": "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides. [EC:3.2.1.53]"}
{"concept_id": "C1819344", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phospholipase A2 activity", "definition": "Any process that modulates the activity of the enzyme phospholipase A2. [GOC:mah]"}
{"concept_id": "C1819345", "aliases": ["upregulation of phospholipase A2 activity", "up regulation of phospholipase A2 activity", "up-regulation of phospholipase A2 activity"], "types": ["T044"], "canonical_name": "positive regulation of phospholipase A2 activity", "definition": "Any process that activates or increases the activity of the enzyme phospholipase A2. [GOC:mah]"}
{"concept_id": "C1819347", "aliases": ["actin cable"], "types": ["T026"], "canonical_name": "actin filament bundle", "definition": "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. [GOC:mah]"}
{"concept_id": "C1819348", "aliases": [], "types": ["T026"], "canonical_name": "filopodium tip", "definition": "The end of a filopodium distal to the body of the cell. [GOC:mah]"}
{"concept_id": "C1819349", "aliases": [], "types": ["T043"], "canonical_name": "regulation of proteasomal ubiquitin-dependent protein catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]"}
{"concept_id": "C1819350", "aliases": ["down-regulation of proteasomal ubiquitin-dependent protein catabolic process", "downregulation of proteasomal ubiquitin-dependent protein catabolic process", "down regulation of proteasomal ubiquitin-dependent protein catabolic process"], "types": ["T043"], "canonical_name": "negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]"}
{"concept_id": "C1819351", "aliases": ["up-regulation of proteasomal ubiquitin-dependent protein catabolic process", "upregulation of proteasomal ubiquitin-dependent protein catabolic process", "up regulation of proteasomal ubiquitin-dependent protein catabolic process"], "types": ["T043"], "canonical_name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]"}
{"concept_id": "C1819352", "aliases": [], "types": ["T026"], "canonical_name": "cuticular plate", "definition": "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted. [PMID:12485990, PMID:2592408, PMID:8071151]"}
{"concept_id": "C1819353", "aliases": ["melanosome organisation", "melanosome organization and biogenesis"], "types": ["T043"], "canonical_name": "melanosome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. [GOC:vk]"}
{"concept_id": "C1819356", "aliases": [], "types": ["T044"], "canonical_name": "pheophorbide a oxygenase activity", "definition": "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O. [PMID:14657372]"}
{"concept_id": "C1819357", "aliases": ["PCBER activity"], "types": ["T044"], "canonical_name": "phenylcoumaran benzylic ether reductase activity", "definition": "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+. [PMID:11030549, PMID:13129921]"}
{"concept_id": "C1819358", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ergosterol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol. [GOC:mah]"}
{"concept_id": "C1819359", "aliases": ["ARF complex location", "ARF complex", "activin responsive factor complex location"], "types": ["T026"], "canonical_name": "activin responsive factor complex", "definition": "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor. [PMID:12374795, PMID:9288972]"}
{"concept_id": "C1819361", "aliases": [], "types": ["T044"], "canonical_name": "protein modification by small protein conjugation", "definition": "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. [GOC:mah]"}
{"concept_id": "C1819362", "aliases": [], "types": ["T044"], "canonical_name": "protein urmylation", "definition": "Covalent attachment of the ubiquitin-like protein URM1 to another protein. [GOC:vw]"}
{"concept_id": "C1819363", "aliases": [], "types": ["T045"], "canonical_name": "DNA hairpin binding", "definition": "Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1819364", "aliases": ["CARMA1-BCL10-Malt1 complex location", "CARMA1-BCL10-Malt1 complex", "CBM complex location"], "types": ["T026"], "canonical_name": "CBM complex", "definition": "A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation. [PMID:12909454, PMID:30467369]"}
{"concept_id": "C1819365", "aliases": ["maltase activity"], "types": ["T044"], "canonical_name": "maltose alpha-glucosidase activity", "definition": "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose. [MetaCyc:RXN-2141]"}
{"concept_id": "C1819366", "aliases": [], "types": ["T044"], "canonical_name": "demethylase activity", "definition": "Catalysis of the removal of a methyl group from a substrate. [GOC:mah]"}
{"concept_id": "C1819367", "aliases": [], "types": ["T044"], "canonical_name": "histone demethylase activity", "definition": "Catalysis of the removal of a methyl group from a histone. [GOC:mah]"}
{"concept_id": "C1819368", "aliases": ["histone demethylase activity (H3-K4 specific)", "histone H3K4 demethylase activity"], "types": ["T044"], "canonical_name": "histone H3-methyl-lysine-4 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein. [GOC:mah]"}
{"concept_id": "C1819369", "aliases": ["H3K49 demethylase activity", "histone demethylase activity (H3-K9 specific)"], "types": ["T044"], "canonical_name": "histone H3-methyl-lysine-9 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein. [PMID:16362057]"}
{"concept_id": "C1819370", "aliases": ["beta-nerve growth factor processing", "NGF processing"], "types": ["T044"], "canonical_name": "nerve growth factor processing", "definition": "The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor. [GOC:mah, PMID:8615794]"}
{"concept_id": "C1819371", "aliases": ["retrograde transport, endosome to plasma membrane"], "types": ["T043"], "canonical_name": "endocytic recycling", "definition": "The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. [PMID:16473635, PMID:23563491]"}
{"concept_id": "C1819372", "aliases": [], "types": ["T043"], "canonical_name": "retrograde transport of endocytic vesicles"}
{"concept_id": "C1819373", "aliases": ["direct endocytic recycling"], "types": ["T043"], "canonical_name": "fast endocytic recycling", "definition": "The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport. [GOC:ecd, PMID:16473635]"}
{"concept_id": "C1819374", "aliases": [], "types": ["T043"], "canonical_name": "slow endocytic recycling", "definition": "The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport. [GOC:ecd, PMID:16473635]"}
{"concept_id": "C1819375", "aliases": [], "types": ["T040"], "canonical_name": "regulation of protein oligomerization", "definition": "Any process that modulates the frequency, rate or extent of protein oligomerization. [GOC:mah]"}
{"concept_id": "C1819376", "aliases": ["downregulation of protein oligomerization", "down-regulation of protein oligomerization", "down regulation of protein oligomerization"], "types": ["T043"], "canonical_name": "negative regulation of protein oligomerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization. [GOC:mah]"}
{"concept_id": "C1819377", "aliases": ["up regulation of protein oligomerization", "upregulation of protein oligomerization", "up-regulation of protein oligomerization"], "types": ["T043"], "canonical_name": "positive regulation of protein oligomerization", "definition": "Any process that activates or increases the frequency, rate or extent of protein oligomerization. [GOC:mah]"}
{"concept_id": "C1819378", "aliases": [], "types": ["T043"], "canonical_name": "induction of protein oligomerization"}
{"concept_id": "C1819379", "aliases": [], "types": ["T040"], "canonical_name": "regulation of protein homooligomerization", "definition": "Any process that modulates the frequency, rate or extent of protein homooligomerization. [GOC:mah]"}
{"concept_id": "C1819380", "aliases": ["down-regulation of protein homooligomerization", "down regulation of protein homooligomerization", "downregulation of protein homooligomerization"], "types": ["T043"], "canonical_name": "negative regulation of protein homooligomerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization. [GOC:mah]"}
{"concept_id": "C1819381", "aliases": ["up-regulation of protein homooligomerization", "up regulation of protein homooligomerization", "upregulation of protein homooligomerization"], "types": ["T043"], "canonical_name": "positive regulation of protein homooligomerization", "definition": "Any process that activates or increases the frequency, rate or extent of protein homooligomerization. [GOC:mah]"}
{"concept_id": "C1819382", "aliases": [], "types": ["T043"], "canonical_name": "induction of protein homooligomerization"}
{"concept_id": "C1819383", "aliases": ["regulation of cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "regulation of cytokinesis", "definition": "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. [GOC:mah]"}
{"concept_id": "C1819384", "aliases": ["down regulation of cytokinesis", "down-regulation of cytokinesis", "downregulation of cytokinesis", "negative regulation of cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "negative regulation of cytokinesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. [GOC:mah]"}
{"concept_id": "C1819385", "aliases": ["up regulation of cytokinesis", "up-regulation of cytokinesis", "upregulation of cytokinesis"], "types": ["T043"], "canonical_name": "positive regulation of cytokinesis", "definition": "Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. [GOC:mah]"}
{"concept_id": "C1819386", "aliases": ["Golgi calcium ion concentration regulation", "calcium ion homeostasis in Golgi", "regulation of calcium ion concentration in Golgi", "regulation of Golgi calcium ion concentration"], "types": ["T043"], "canonical_name": "Golgi calcium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings. [GOC:mah]"}
{"concept_id": "C1819387", "aliases": ["regulation of endoplasmic reticulum calcium ion concentration", "regulation of calcium ion concentration in endoplasmic reticulum", "calcium ion homeostasis in endoplasmic reticulum", "ER calcium ion homeostasis", "regulation of ER calcium ion concentration", "regulation of calcium ion concentration in ER", "endoplasmic reticulum calcium ion concentration regulation", "ER calcium ion concentration regulation", "calcium ion homeostasis in ER"], "types": ["T043"], "canonical_name": "endoplasmic reticulum calcium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. [GOC:mah]"}
{"concept_id": "C1819388", "aliases": ["elevation of ER calcium ion concentration", "elevation of endoplasmic reticulum calcium ion concentration", "endoplasmic reticulum calcium ion concentration elevation", "elevation of calcium ion concentration in endoplasmic reticulum"], "types": ["T043"], "canonical_name": "positive regulation of endoplasmic reticulum calcium ion concentration", "definition": "Any process that increases the concentration of calcium ions in the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C1819389", "aliases": ["ER calcium ion concentration reduction", "reduction of ER calcium ion concentration", "reduction of calcium ion concentration in ER", "reduction of calcium ion concentration in endoplasmic reticulum", "reduction of endoplasmic reticulum calcium ion concentration", "endoplasmic reticulum calcium ion concentration reduction"], "types": ["T043"], "canonical_name": "negative regulation of endoplasmic reticulum calcium ion concentration", "definition": "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C1819390", "aliases": ["Golgi calcium transport"], "types": ["T043"], "canonical_name": "Golgi calcium ion transport", "definition": "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus. [GOC:mah]"}
{"concept_id": "C1819391", "aliases": ["external leaflet of mitochondrial outer membrane", "external side of mitochondrial outer membrane", "cytosolic side of mitochondrial outer membrane"], "types": ["T026"], "canonical_name": "cytoplasmic side of mitochondrial outer membrane", "definition": "The external (cytoplasmic) face of the mitochondrial outer membrane. [GOC:mah]"}
{"concept_id": "C1819392", "aliases": [], "types": ["T026"], "canonical_name": "external side of mitochondrial envelope"}
{"concept_id": "C1819393", "aliases": [], "types": ["T040"], "canonical_name": "otolith morphogenesis", "definition": "The process in which the anatomical structures of an otolith are generated and organized. [GOC:dgh]"}
{"concept_id": "C1819394", "aliases": [], "types": ["T040"], "canonical_name": "otolith formation", "definition": "The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts. [GOC:dgh]"}
{"concept_id": "C1819395", "aliases": ["decaprenyl diphosphate synthase complex location"], "types": ["T026"], "canonical_name": "decaprenyl diphosphate synthase complex", "definition": "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. [GOC:mah, PMID:14519123]"}
{"concept_id": "C1819396", "aliases": ["homodimeric decaprenyl diphosphate synthase complex location"], "types": ["T026"], "canonical_name": "homodimeric decaprenyl diphosphate synthase complex", "definition": "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. [PMID:14519123]"}
{"concept_id": "C1819397", "aliases": ["heterotetrameric decaprenyl diphosphate synthase complex location"], "types": ["T026"], "canonical_name": "heterotetrameric decaprenyl diphosphate synthase complex", "definition": "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1. [PMID:14519123]"}
{"concept_id": "C1819398", "aliases": ["regulation of type I IFN production"], "types": ["T040"], "canonical_name": "regulation of type I interferon production", "definition": "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:mah]"}
{"concept_id": "C1819399", "aliases": ["negative regulation of type I IFN production", "down-regulation of type I interferon production", "down regulation of type I interferon production", "downregulation of type I interferon production"], "types": ["T040"], "canonical_name": "negative regulation of type I interferon production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:mah]"}
{"concept_id": "C1819400", "aliases": ["up-regulation of type I interferon production", "up regulation of type I interferon production", "upregulation of type I interferon production", "positive regulation of type I IFN production"], "types": ["T040"], "canonical_name": "positive regulation of type I interferon production", "definition": "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:mah]"}
{"concept_id": "C1819401", "aliases": [], "types": ["T044"], "canonical_name": "Rab protein signal transduction", "definition": "The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. [GOC:mah]"}
{"concept_id": "C1819402", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Rab protein signal transduction", "definition": "Any process that modulates the frequency, rate or extent of Rab protein signal transduction. [GOC:mah]"}
{"concept_id": "C1819403", "aliases": [], "types": ["T044"], "canonical_name": "Ral protein signal transduction", "definition": "The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state. [GOC:mah]"}
{"concept_id": "C1819404", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Ral protein signal transduction", "definition": "Any process that modulates the frequency, rate or extent of Ral protein signal transduction. [GOC:mah]"}
{"concept_id": "C1819405", "aliases": [], "types": ["T044"], "canonical_name": "Rap protein signal transduction", "definition": "The series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state. [GOC:mah]"}
{"concept_id": "C1819406", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Rap protein signal transduction", "definition": "Any process that modulates the frequency, rate or extent of Rap protein signal transduction. [GOC:mah]"}
{"concept_id": "C1819407", "aliases": [], "types": ["T044"], "canonical_name": "Cdc42 protein signal transduction", "definition": "The series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state. [GOC:mah, PMID:18558478]"}
{"concept_id": "C1819408", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Cdc42 protein signal transduction", "definition": "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction. [GOC:mah]"}
{"concept_id": "C1819409", "aliases": ["detection of bacterium associated molecule", "detection of bacterial associated molecule", "detection of bacteria associated molecule"], "types": ["T043"], "canonical_name": "detection of molecule of bacterial origin", "definition": "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. [GOC:add, GOC:rl]"}
{"concept_id": "C1819410", "aliases": ["detection of fungal associated molecule", "detection of fungus associated molecule"], "types": ["T043"], "canonical_name": "detection of molecule of fungal origin", "definition": "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal. [GOC:mah, GOC:rl]"}
{"concept_id": "C1819411", "aliases": ["detection of oomycetes associated molecule"], "types": ["T043"], "canonical_name": "detection of molecule of oomycetes origin", "definition": "The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal. [GOC:mah, GOC:rl]"}
{"concept_id": "C1819412", "aliases": [], "types": ["T040"], "canonical_name": "response to bacterial lipoprotein", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus. [GOC:add, PMID:12077222]"}
{"concept_id": "C1819413", "aliases": [], "types": ["T040"], "canonical_name": "response to peptidoglycan", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. [GOC:add, ISBN:0721601464]"}
{"concept_id": "C1819414", "aliases": [], "types": ["T040"], "canonical_name": "response to muramyl dipeptide", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. [GOC:add]"}
{"concept_id": "C1819415", "aliases": ["response to LPS"], "types": ["T040"], "canonical_name": "response to lipopolysaccharide", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]"}
{"concept_id": "C1819416", "aliases": ["detection of LPS"], "types": ["T043"], "canonical_name": "detection of lipopolysaccharide", "definition": "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, PMID:15998797]"}
{"concept_id": "C1819417", "aliases": [], "types": ["T043"], "canonical_name": "detection of muramyl dipeptide", "definition": "The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan. [GOC:rl, PMID:15998797]"}
{"concept_id": "C1819418", "aliases": [], "types": ["T043"], "canonical_name": "detection of peptidoglycan", "definition": "The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule. [GOC:add, ISBN:0721601464]"}
{"concept_id": "C1819419", "aliases": [], "types": ["T044"], "canonical_name": "muramyl dipeptide binding", "definition": "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan. [GOC:rl]"}
{"concept_id": "C1819420", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organism reproduction", "definition": "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. [GOC:isa_complete, GOC:jid]"}
{"concept_id": "C1819421", "aliases": [], "types": ["T040"], "canonical_name": "reproduction of a single-celled organism", "definition": "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. [GOC:isa_complete]"}
{"concept_id": "C1819422", "aliases": [], "types": ["T043"], "canonical_name": "cytokinetic process", "definition": "A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). [GOC:bf, GOC:isa_complete, GOC:mah]"}
{"concept_id": "C1819424", "aliases": ["DNA unwinding", "duplex DNA melting"], "types": ["T045"], "canonical_name": "DNA duplex unwinding", "definition": "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. [GOC:isa_complete, GOC:mah]"}
{"concept_id": "C1819425", "aliases": ["CTGF production", "Fisp12 production", "hypertrophic chondrocyte-specific gene product 24 production", "IGFBP8 production", "CCN2 production", "Hcs24 production"], "types": ["T040"], "canonical_name": "connective tissue growth factor production", "definition": "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819426", "aliases": ["chemokine biosynthesis", "chemokine synthesis", "chemokine formation", "chemokine anabolism"], "types": ["T040"], "canonical_name": "chemokine production", "definition": "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, ISBN:0198506732, PMID:12183377, Wikipedia:Chemokine]"}
{"concept_id": "C1819427", "aliases": ["CX3CL1 production", "ABCD-3 production", "neurotactin production"], "types": ["T040"], "canonical_name": "fractalkine production", "definition": "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:12729461]"}
{"concept_id": "C1819428", "aliases": ["GM-CSF production", "granulocyte macrophage colony stimulating factor production"], "types": ["T040"], "canonical_name": "granulocyte macrophage colony-stimulating factor production", "definition": "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C1819429", "aliases": ["HGF production", "scatter factor production"], "types": ["T040"], "canonical_name": "hepatocyte growth factor production", "definition": "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:1838014]"}
{"concept_id": "C1819430", "aliases": ["type I IFN production", "interferon type I production"], "types": ["T040"], "canonical_name": "type I interferon production", "definition": "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]"}
{"concept_id": "C1819431", "aliases": ["IFN-alpha production", "IFNA production"], "types": ["T040"], "canonical_name": "interferon-alpha production", "definition": "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:15546383]"}
{"concept_id": "C1819432", "aliases": ["IFN-beta production", "IFNB production"], "types": ["T040"], "canonical_name": "interferon-beta production", "definition": "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:15546383]"}
{"concept_id": "C1819433", "aliases": ["type II IFN production", "type II interferon production", "IFNG production"], "types": ["T040"], "canonical_name": "interferon-gamma production", "definition": "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]"}
{"concept_id": "C1819434", "aliases": ["IL-1 alpha production"], "types": ["T040"], "canonical_name": "interleukin-1 alpha production", "definition": "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819435", "aliases": ["IL-1 beta production"], "types": ["T040"], "canonical_name": "interleukin-1 beta production", "definition": "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819436", "aliases": ["IL-1 production"], "types": ["T040"], "canonical_name": "interleukin-1 production", "definition": "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819437", "aliases": ["IL-10 production"], "types": ["T040"], "canonical_name": "interleukin-10 production", "definition": "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819438", "aliases": ["IL-11 production"], "types": ["T040"], "canonical_name": "interleukin-11 production", "definition": "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819439", "aliases": ["IL-12 production"], "types": ["T040"], "canonical_name": "interleukin-12 production", "definition": "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819440", "aliases": ["IL-13 production"], "types": ["T040"], "canonical_name": "interleukin-13 production", "definition": "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819442", "aliases": ["IL-15 production"], "types": ["T040"], "canonical_name": "interleukin-15 production", "definition": "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819443", "aliases": ["pro-interleukin-16 production", "IL-16 production"], "types": ["T040"], "canonical_name": "interleukin-16 production", "definition": "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819444", "aliases": ["IL-17 production", "CTLA-8 production", "Cytotoxic T-lymphocyte-associated antigen 8 production"], "types": ["T040"], "canonical_name": "interleukin-17 production", "definition": "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, GOC:rv, Wikipedia:Interleukin_17]"}
{"concept_id": "C1819445", "aliases": ["IGIF production", "IL-18 production"], "types": ["T040"], "canonical_name": "interleukin-18 production", "definition": "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819446", "aliases": ["IL-19 production"], "types": ["T040"], "canonical_name": "interleukin-19 production", "definition": "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819447", "aliases": ["IL-2 production"], "types": ["T040"], "canonical_name": "interleukin-2 production", "definition": "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819448", "aliases": ["IL-20 production", "ZCYTO10 production"], "types": ["T040"], "canonical_name": "interleukin-20 production", "definition": "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819449", "aliases": ["IL-21 production"], "types": ["T040"], "canonical_name": "interleukin-21 production", "definition": "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819450", "aliases": ["ILTIF production", "IL-22 production", "IL22 production"], "types": ["T040"], "canonical_name": "interleukin-22 production", "definition": "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819451", "aliases": ["IL-23 production"], "types": ["T040"], "canonical_name": "interleukin-23 production", "definition": "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819452", "aliases": ["IL-24 production"], "types": ["T040"], "canonical_name": "interleukin-24 production", "definition": "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819453", "aliases": ["IL-25 production"], "types": ["T040"], "canonical_name": "interleukin-25 production", "definition": "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819454", "aliases": ["IL-26 production"], "types": ["T040"], "canonical_name": "interleukin-26 production", "definition": "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819455", "aliases": ["IL-27 production"], "types": ["T040"], "canonical_name": "interleukin-27 production", "definition": "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819456", "aliases": ["IL-3 production"], "types": ["T040"], "canonical_name": "interleukin-3 production", "definition": "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819457", "aliases": ["IL-4 production"], "types": ["T040"], "canonical_name": "interleukin-4 production", "definition": "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819458", "aliases": ["IL-5 production"], "types": ["T040"], "canonical_name": "interleukin-5 production", "definition": "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819459", "aliases": ["IL-6 production"], "types": ["T040"], "canonical_name": "interleukin-6 production", "definition": "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819460", "aliases": ["IL-7 production"], "types": ["T040"], "canonical_name": "interleukin-7 production", "definition": "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819461", "aliases": ["IL-8 production"], "types": ["T040"], "canonical_name": "interleukin-8 production", "definition": "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819462", "aliases": ["IL-9 production"], "types": ["T040"], "canonical_name": "interleukin-9 production", "definition": "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C1819463", "aliases": [], "types": ["T040"], "canonical_name": "TRAIL production", "definition": "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:9311998]"}
{"concept_id": "C1819464", "aliases": ["TNF production", "cachectin production", "tumor necrosis factor-alpha production", "TNF-alpha production"], "types": ["T040"], "canonical_name": "tumor necrosis factor production", "definition": "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. [GOC:mah, PMID:10891884, PMID:15560120]"}
{"concept_id": "C1819465", "aliases": ["TNF-B production", "LTA production", "lymphotoxin-alpha production", "tumor necrosis factor-beta production", "TNF-beta production"], "types": ["T040"], "canonical_name": "lymphotoxin A production", "definition": "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A. [GOC:jl]"}
{"concept_id": "C1819466", "aliases": [], "types": ["T040"], "canonical_name": "regulation of chemokine production", "definition": "Any process that modulates the frequency, rate, or extent of chemokine production. [GOC:mah]"}
{"concept_id": "C1819467", "aliases": ["regulation of CCN2 production", "regulation of IGFBP8 production", "regulation of hypertrophic chondrocyte-specific gene product 24 production", "regulation of Fisp12 production", "regulation of CTGF production", "regulation of Hcs24 production"], "types": ["T040"], "canonical_name": "regulation of connective tissue growth factor production", "definition": "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production. [GOC:mah]"}
{"concept_id": "C1819468", "aliases": [], "types": ["T040"], "canonical_name": "regulation of fractalkine production", "definition": "Any process that modulates the frequency, rate, or extent of fractalkine production. [GOC:mah]"}
{"concept_id": "C1819469", "aliases": ["regulation of granulocyte macrophage colony stimulating factor production", "regulation of GM-CSF production"], "types": ["T040"], "canonical_name": "regulation of granulocyte macrophage colony-stimulating factor production", "definition": "Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. [GOC:mah]"}
{"concept_id": "C1819470", "aliases": ["regulation of HGF production", "regulation of scatter factor production"], "types": ["T040"], "canonical_name": "regulation of hepatocyte growth factor production", "definition": "Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production. [GOC:mah, PMID:1838014]"}
{"concept_id": "C1819471", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interferon-alpha production", "definition": "Any process that modulates the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383]"}
{"concept_id": "C1819472", "aliases": ["regulation of IFN-beta production"], "types": ["T040"], "canonical_name": "regulation of interferon-beta production", "definition": "Any process that modulates the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383]"}
{"concept_id": "C1819473", "aliases": ["regulation of type II interferon production"], "types": ["T040"], "canonical_name": "regulation of interferon-gamma production", "definition": "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]"}
{"concept_id": "C1819474", "aliases": ["regulation of IL-1 alpha production"], "types": ["T040"], "canonical_name": "regulation of interleukin-1 alpha production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production. [GOC:mah]"}
{"concept_id": "C1819475", "aliases": ["regulation of IL-1 beta production"], "types": ["T040"], "canonical_name": "regulation of interleukin-1 beta production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]"}
{"concept_id": "C1819476", "aliases": ["regulation of IL-1 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-1 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-1 production. [GOC:mah]"}
{"concept_id": "C1819477", "aliases": ["regulation of IL-10 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-10 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-10 production. [GOC:mah]"}
{"concept_id": "C1819478", "aliases": ["regulation of IL-11 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-11 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-11 production. [GOC:mah, PMID:29286137]"}
{"concept_id": "C1819479", "aliases": ["regulation of IL-12 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-12 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-12 production. [GOC:mah]"}
{"concept_id": "C1819480", "aliases": ["regulation of IL-13 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-13 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-13 production. [GOC:mah]"}
{"concept_id": "C1819482", "aliases": ["regulation of IL-15 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-15 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-15 production. [GOC:mah]"}
{"concept_id": "C1819483", "aliases": ["regulation of IL-16 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-16 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-16 production. [GOC:mah]"}
{"concept_id": "C1819484", "aliases": ["regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion", "regulation of IL-17 production", "regulation of CTLA-8 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-17 production", "definition": "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. [GOC:add, GOC:mah, PMID:16482511]"}
{"concept_id": "C1819485", "aliases": ["regulation of IL-18 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-18 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-18 production. [GOC:mah, PMID:23710316]"}
{"concept_id": "C1819486", "aliases": ["regulation of IL-19 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-19 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-19 production. [GOC:mah]"}
{"concept_id": "C1819487", "aliases": ["regulation of IL-2 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-2 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-2 production. [GOC:mah]"}
{"concept_id": "C1819488", "aliases": ["regulation of IL-20 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-20 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-20 production. [GOC:mah]"}
{"concept_id": "C1819489", "aliases": ["regulation of IL-21 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-21 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-21 production. [GOC:mah]"}
{"concept_id": "C1819490", "aliases": ["regulation of IL-22 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-22 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-22 production. [GOC:mah]"}
{"concept_id": "C1819491", "aliases": ["regulation of IL-23 production", "regulation of IL-23 biosynthetic process"], "types": ["T040"], "canonical_name": "regulation of interleukin-23 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-23 production. [GOC:mah]"}
{"concept_id": "C1819492", "aliases": ["regulation of IL-24 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-24 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-24 production. [GOC:mah]"}
{"concept_id": "C1819493", "aliases": ["regulation of IL-25 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-25 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-25 production. [GOC:mah, PMID:27901018]"}
{"concept_id": "C1819494", "aliases": ["regulation of IL-26 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-26 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-26 production. [GOC:mah]"}
{"concept_id": "C1819495", "aliases": ["regulation of IL-27 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-27 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-27 production. [GOC:mah]"}
{"concept_id": "C1819496", "aliases": ["regulation of IL-3 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-3 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-3 production. [GOC:mah]"}
{"concept_id": "C1819497", "aliases": ["regulation of IL-4 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-4 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-4 production. [GOC:mah, PMID:29778524]"}
{"concept_id": "C1819498", "aliases": ["regulation of IL-5 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-5 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-5 production. [GOC:mah]"}
{"concept_id": "C1819499", "aliases": ["regulation of IL-6 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-6 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-6 production. [GOC:mah]"}
{"concept_id": "C1819500", "aliases": ["regulation of IL-7 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-7 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-7 production. [GOC:mah, PMID:25962782]"}
{"concept_id": "C1819501", "aliases": ["regulation of IL-8 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-8 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-8 production. [GOC:mah]"}
{"concept_id": "C1819502", "aliases": ["regulation of IL-9 production"], "types": ["T040"], "canonical_name": "regulation of interleukin-9 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-9 production. [GOC:mah]"}
{"concept_id": "C1819503", "aliases": [], "types": ["T040"], "canonical_name": "regulation of TRAIL production", "definition": "Any process that modulates the frequency, rate, or extent of TRAIL production. [GOC:mah]"}
{"concept_id": "C1819504", "aliases": ["regulation of TNF production", "regulation of TNF-alpha production", "regulation of tumor necrosis factor-alpha production", "regulation of cachectin production"], "types": ["T040"], "canonical_name": "regulation of tumor necrosis factor production", "definition": "Any process that modulates the frequency, rate or extent of tumor necrosis factor production. [GOC:mah, PMID:10891884, PMID:15560120]"}
{"concept_id": "C1819505", "aliases": ["regulation of lymphotoxin-alpha production", "regulation of TNF-beta production", "regulation of LTA production", "regulation of tumor necrosis factor-beta production"], "types": ["T040"], "canonical_name": "regulation of lymphotoxin A production", "definition": "Any process that modulates the frequency, rate, or extent of lymphotoxin A production. [GOC:mah]"}
{"concept_id": "C1819506", "aliases": ["down regulation of chemokine production", "downregulation of chemokine production", "down-regulation of chemokine production"], "types": ["T040"], "canonical_name": "negative regulation of chemokine production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. [GOC:mah]"}
{"concept_id": "C1819507", "aliases": ["negative regulation of CCN2 production", "downregulation of connective tissue growth factor production", "down-regulation of connective tissue growth factor production", "negative regulation of IGFBP8 production", "down regulation of connective tissue growth factor production", "negative regulation of Hcs24 production", "negative regulation of CTGF production", "negative regulation of hypertrophic chondrocyte-specific gene product 24 production", "negative regulation of Fisp12 production"], "types": ["T040"], "canonical_name": "negative regulation of connective tissue growth factor production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production. [GOC:mah]"}
{"concept_id": "C1819508", "aliases": ["downregulation of fractalkine production", "negative regulation of CX3CL1 production", "down-regulation of fractalkine production", "down regulation of fractalkine production"], "types": ["T040"], "canonical_name": "negative regulation of fractalkine production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production. [GOC:mah]"}
{"concept_id": "C1819509", "aliases": ["down-regulation of granulocyte macrophage colony-stimulating factor production", "negative regulation of granulocyte macrophage colony stimulating factor production", "down regulation of granulocyte macrophage colony-stimulating factor production", "downregulation of granulocyte macrophage colony-stimulating factor production", "negative regulation of GM-CSF production"], "types": ["T040"], "canonical_name": "negative regulation of granulocyte macrophage colony-stimulating factor production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. [GOC:mah]"}
{"concept_id": "C1819510", "aliases": ["negative regulation of scatter factor production", "down regulation of hepatocyte growth factor production", "down-regulation of hepatocyte growth factor production", "negative regulation of HGF production", "downregulation of hepatocyte growth factor production"], "types": ["T040"], "canonical_name": "negative regulation of hepatocyte growth factor production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production. [GOC:mah, PMID:1838014]"}
{"concept_id": "C1819511", "aliases": ["downregulation of interferon-alpha production", "down-regulation of interferon-alpha production", "down regulation of interferon-alpha production"], "types": ["T040"], "canonical_name": "negative regulation of interferon-alpha production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383]"}
{"concept_id": "C1819512", "aliases": ["downregulation of interferon-beta production", "negative regulation of IFN-beta production", "down regulation of interferon-beta production", "down-regulation of interferon-beta production"], "types": ["T040"], "canonical_name": "negative regulation of interferon-beta production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383]"}
{"concept_id": "C1819513", "aliases": ["down regulation of interferon-gamma production", "downregulation of interferon-gamma production", "negative regulation of type II interferon production", "down-regulation of interferon-gamma production"], "types": ["T040"], "canonical_name": "negative regulation of interferon-gamma production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]"}
{"concept_id": "C1819514", "aliases": ["downregulation of interleukin-1 alpha production", "down regulation of interleukin-1 alpha production", "down-regulation of interleukin-1 alpha production", "negative regulation of IL-1 alpha production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-1 alpha production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production. [GOC:mah]"}
{"concept_id": "C1819515", "aliases": ["downregulation of interleukin-1 beta production", "negative regulation of IL-1 beta production", "down regulation of interleukin-1 beta production", "down-regulation of interleukin-1 beta production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-1 beta production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]"}
{"concept_id": "C1819516", "aliases": ["down-regulation of interleukin-1 production", "downregulation of interleukin-1 production", "negative regulation of IL-1 production", "down regulation of interleukin-1 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-1 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. [GOC:mah]"}
{"concept_id": "C1819517", "aliases": ["down-regulation of interleukin-10 production", "down regulation of interleukin-10 production", "downregulation of interleukin-10 production", "negative regulation of IL-10 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-10 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. [GOC:mah]"}
{"concept_id": "C1819518", "aliases": ["down regulation of interleukin-11 production", "negative regulation of IL-11 production", "downregulation of interleukin-11 production", "down-regulation of interleukin-11 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-11 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production. [GOC:mah, PMID:29286137]"}
{"concept_id": "C1819519", "aliases": ["downregulation of interleukin-12 production", "down-regulation of interleukin-12 production", "negative regulation of IL-12 production", "down regulation of interleukin-12 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-12 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. [GOC:mah]"}
{"concept_id": "C1819520", "aliases": ["downregulation of interleukin-13 production", "down-regulation of interleukin-13 production", "negative regulation of IL-13 production", "down regulation of interleukin-13 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-13 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production. [GOC:mah]"}
{"concept_id": "C1819522", "aliases": ["down regulation of interleukin-15 production", "negative regulation of IL-15 production", "downregulation of interleukin-15 production", "down-regulation of interleukin-15 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-15 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production. [GOC:mah]"}
{"concept_id": "C1819523", "aliases": ["downregulation of interleukin-16 production", "negative regulation of IL-16 production", "down-regulation of interleukin-16 production", "down regulation of interleukin-16 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-16 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production. [GOC:mah]"}
{"concept_id": "C1819524", "aliases": ["negative regulation of IL-17 production", "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion", "down regulation of interleukin-17 production", "downregulation of interleukin-17 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-17 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. [GOC:add, GOC:mah, PMID:16482511]"}
{"concept_id": "C1819525", "aliases": ["negative regulation of IL-18 production", "downregulation of interleukin-18 production", "down-regulation of interleukin-18 production", "down regulation of interleukin-18 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-18 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production. [GOC:mah, PMID:23710316]"}
{"concept_id": "C1819526", "aliases": ["down-regulation of interleukin-19 production", "negative regulation of IL-19 production", "down regulation of interleukin-19 production", "downregulation of interleukin-19 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-19 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production. [GOC:mah]"}
{"concept_id": "C1819527", "aliases": ["negative regulation of IL-2 production", "down regulation of interleukin-2 production", "down-regulation of interleukin-2 production", "downregulation of interleukin-2 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-2 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. [GOC:mah]"}
{"concept_id": "C1819528", "aliases": ["down regulation of interleukin-20 production", "down-regulation of interleukin-20 production", "downregulation of interleukin-20 production", "negative regulation of IL-20 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-20 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production. [GOC:mah]"}
{"concept_id": "C1819529", "aliases": ["down-regulation of interleukin-21 production", "downregulation of interleukin-21 production", "down regulation of interleukin-21 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-21 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production. [GOC:mah]"}
{"concept_id": "C1819530", "aliases": ["negative regulation of IL-22 production", "down regulation of interleukin-22 production", "downregulation of interleukin-22 production", "down-regulation of interleukin-22 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-22 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production. [GOC:mah]"}
{"concept_id": "C1819531", "aliases": ["downregulation of interleukin-23 production", "down-regulation of interleukin-23 production", "negative regulation of IL-23 production", "down regulation of interleukin-23 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-23 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production. [GOC:mah]"}
{"concept_id": "C1819532", "aliases": ["down regulation of interleukin-24 production", "negative regulation of IL-24 production", "down-regulation of interleukin-24 production", "downregulation of interleukin-24 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-24 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production. [GOC:mah]"}
{"concept_id": "C1819533", "aliases": ["down-regulation of interleukin-25 production", "down regulation of interleukin-25 production", "downregulation of interleukin-25 production", "negative regulation of IL-25 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-25 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production. [GOC:mah]"}
{"concept_id": "C1819534", "aliases": ["down-regulation of interleukin-26 production", "downregulation of interleukin-26 production", "negative regulation of IL-26 production", "down regulation of interleukin-26 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-26 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production. [GOC:mah]"}
{"concept_id": "C1819535", "aliases": ["down regulation of interleukin-27 production", "negative regulation of IL-27 production", "down-regulation of interleukin-27 production", "downregulation of interleukin-27 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-27 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production. [GOC:mah]"}
{"concept_id": "C1819536", "aliases": ["negative regulation of IL-3 production", "downregulation of interleukin-3 production", "down regulation of interleukin-3 production", "down-regulation of interleukin-3 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-3 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production. [GOC:mah]"}
{"concept_id": "C1819537", "aliases": ["down regulation of interleukin-4 production", "negative regulation of IL-4 production", "downregulation of interleukin-4 production", "down-regulation of interleukin-4 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-4 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production. [GOC:mah, PMID:29778524]"}
{"concept_id": "C1819538", "aliases": ["down-regulation of interleukin-5 production", "down regulation of interleukin-5 production", "downregulation of interleukin-5 production", "negative regulation of IL-5 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-5 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production. [GOC:mah]"}
{"concept_id": "C1819539", "aliases": ["down regulation of interleukin-6 production", "negative regulation of IL-6 production", "downregulation of interleukin-6 production", "down-regulation of interleukin-6 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-6 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. [GOC:mah]"}
{"concept_id": "C1819540", "aliases": ["down-regulation of interleukin-7 production", "down regulation of interleukin-7 production", "negative regulation of IL-7 production", "downregulation of interleukin-7 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-7 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production. [GOC:mah, PMID:25962782]"}
{"concept_id": "C1819541", "aliases": ["down regulation of interleukin-8 production", "negative regulation of IL-8 production", "downregulation of interleukin-8 production", "down-regulation of interleukin-8 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-8 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. [GOC:mah]"}
{"concept_id": "C1819542", "aliases": ["down-regulation of interleukin-9 production", "negative regulation of IL-9 production", "downregulation of interleukin-9 production", "down regulation of interleukin-9 production"], "types": ["T040"], "canonical_name": "negative regulation of interleukin-9 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production. [GOC:mah]"}
{"concept_id": "C1819543", "aliases": ["down-regulation of TRAIL production", "downregulation of TRAIL production", "down regulation of TRAIL production"], "types": ["T040"], "canonical_name": "negative regulation of TRAIL production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production. [GOC:mah]"}
{"concept_id": "C1819544", "aliases": ["negative regulation TNF-alpha production", "down-regulation of tumor necrosis factor production", "downregulation of tumor necrosis factor production", "negative regulation TNF production", "down regulation of tumor necrosis factor production", "negative regulation tumor necrosis factor-alpha production"], "types": ["T040"], "canonical_name": "negative regulation of tumor necrosis factor production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. [GOC:mah, PMID:10891884, PMID:15560120]"}
{"concept_id": "C1819545", "aliases": ["negative regulation of tumor necrosis factor-beta production", "down-regulation of lymphotoxin A production", "down regulation of lymphotoxin A production", "negative regulation of LTA production", "negative regulation of TNF-beta production", "negative regulation of lymphotoxin-alpha production", "downregulation of lymphotoxin A production"], "types": ["T040"], "canonical_name": "negative regulation of lymphotoxin A production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production. [GOC:mah]"}
{"concept_id": "C1819546", "aliases": ["up-regulation of chemokine production", "upregulation of chemokine production", "up regulation of chemokine production"], "types": ["T040"], "canonical_name": "positive regulation of chemokine production", "definition": "Any process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah]"}
{"concept_id": "C1819547", "aliases": ["positive regulation of Hcs24 production", "up regulation of connective tissue growth factor production", "positive regulation of CTGF production", "positive regulation of Fisp12 production", "positive regulation of CCN2 production", "up-regulation of connective tissue growth factor production", "positive regulation of IGFBP8 production", "upregulation of connective tissue growth factor production", "positive regulation of hypertrophic chondrocyte-specific gene product 24 production"], "types": ["T040"], "canonical_name": "positive regulation of connective tissue growth factor production", "definition": "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production. [GOC:mah]"}
{"concept_id": "C1819548", "aliases": ["upregulation of fractalkine production", "up regulation of fractalkine production", "up-regulation of fractalkine production"], "types": ["T040"], "canonical_name": "positive regulation of fractalkine production", "definition": "Any process that activates or increases the frequency, rate, or extent of fractalkine production. [GOC:mah]"}
{"concept_id": "C1819549", "aliases": ["upregulation of granulocyte macrophage colony-stimulating factor production", "up regulation of granulocyte macrophage colony-stimulating factor production", "positive regulation of granulocyte macrophage colony stimulating factor production", "positive regulation of GM-CSF production", "up-regulation of granulocyte macrophage colony-stimulating factor production"], "types": ["T040"], "canonical_name": "positive regulation of granulocyte macrophage colony-stimulating factor production", "definition": "Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. [GOC:mah]"}
{"concept_id": "C1819550", "aliases": ["up regulation of hepatocyte growth factor production", "positive regulation of HGF production", "positive regulation of scatter factor production", "up-regulation of hepatocyte growth factor production", "upregulation of hepatocyte growth factor production"], "types": ["T040"], "canonical_name": "positive regulation of hepatocyte growth factor production", "definition": "Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production. [GOC:mah, PMID:1838014]"}
{"concept_id": "C1819551", "aliases": ["up-regulation of interferon-alpha production", "upregulation of interferon-alpha production", "up regulation of interferon-alpha production"], "types": ["T040"], "canonical_name": "positive regulation of interferon-alpha production", "definition": "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383]"}
{"concept_id": "C1819552", "aliases": ["up-regulation of interferon-beta production", "up regulation of interferon-beta production", "positive regulation of IFN-beta production", "upregulation of interferon-beta production"], "types": ["T040"], "canonical_name": "positive regulation of interferon-beta production", "definition": "Any process that activates or increases the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383]"}
{"concept_id": "C1819553", "aliases": ["positive regulation of type II interferon production", "up-regulation of interferon-gamma production", "upregulation of interferon-gamma production", "up regulation of interferon-gamma production"], "types": ["T040"], "canonical_name": "positive regulation of interferon-gamma production", "definition": "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]"}
{"concept_id": "C1819554", "aliases": ["up regulation of interleukin-1 alpha production", "positive regulation of IL-1 alpha production", "up-regulation of interleukin-1 alpha production", "upregulation of interleukin-1 alpha production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-1 alpha production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production. [GOC:mah]"}
{"concept_id": "C1819555", "aliases": ["up-regulation of interleukin-1 beta production", "positive regulation of IL-1 beta production", "upregulation of interleukin-1 beta production", "up regulation of interleukin-1 beta production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-1 beta production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]"}
{"concept_id": "C1819556", "aliases": ["upregulation of interleukin-1 production", "positive regulation of IL-1 production", "up-regulation of interleukin-1 production", "up regulation of interleukin-1 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-1 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. [GOC:mah]"}
{"concept_id": "C1819557", "aliases": ["up-regulation of interleukin-10 production", "up regulation of interleukin-10 production", "positive regulation of IL-10 production", "upregulation of interleukin-10 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-10 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. [GOC:mah]"}
{"concept_id": "C1819558", "aliases": ["up regulation of interleukin-11 production", "upregulation of interleukin-11 production", "up-regulation of interleukin-11 production", "positive regulation of IL-11 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-11 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production. [GOC:mah]"}
{"concept_id": "C1819559", "aliases": ["positive regulation of IL-12 production", "up-regulation of interleukin-12 production", "up regulation of interleukin-12 production", "upregulation of interleukin-12 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-12 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. [GOC:mah]"}
{"concept_id": "C1819560", "aliases": ["upregulation of interleukin-13 production", "up regulation of interleukin-13 production", "up-regulation of interleukin-13 production", "positive regulation of IL-13 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-13 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. [GOC:mah]"}
{"concept_id": "C1819562", "aliases": ["positive regulation of IL-15 production", "up regulation of interleukin-15 production", "upregulation of interleukin-15 production", "up-regulation of interleukin-15 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-15 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production. [GOC:mah]"}
{"concept_id": "C1819563", "aliases": ["upregulation of interleukin-16 production", "up regulation of interleukin-16 production", "up-regulation of interleukin-16 production", "positive regulation of IL-16 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-16 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production. [GOC:mah]"}
{"concept_id": "C1819564", "aliases": ["up regulation of interleukin-17 production", "upregulation of interleukin-17 production", "up-regulation of interleukin-17 production", "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 production", "positive regulation of IL-17 production", "positive regulation of CTLA-8 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-17 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. [GOC:add, GOC:mah, PMID:16482511]"}
{"concept_id": "C1819565", "aliases": ["up-regulation of interleukin-18 production", "positive regulation of IL-18 production", "up regulation of interleukin-18 production", "upregulation of interleukin-18 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-18 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production. [GOC:mah]"}
{"concept_id": "C1819566", "aliases": ["positive regulation of IL-19 production", "upregulation of interleukin-19 production", "up-regulation of interleukin-19 production", "up regulation of interleukin-19 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-19 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production. [GOC:mah]"}
{"concept_id": "C1819567", "aliases": ["positive regulation of IL-2 production", "up regulation of interleukin-2 production", "up-regulation of interleukin-2 production", "upregulation of interleukin-2 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-2 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. [GOC:mah]"}
{"concept_id": "C1819568", "aliases": ["positive regulation of IL-20 production", "up regulation of interleukin-20 production", "upregulation of interleukin-20 production", "up-regulation of interleukin-20 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-20 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production. [GOC:mah]"}
{"concept_id": "C1819569", "aliases": ["upregulation of interleukin-21 production", "positive regulation of IL-21 production", "up-regulation of interleukin-21 production", "up regulation of interleukin-21 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-21 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production. [GOC:mah]"}
{"concept_id": "C1819570", "aliases": ["upregulation of interleukin-22 production", "positive regulation of IL-22 production", "up-regulation of interleukin-22 production", "up regulation of interleukin-22 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-22 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production. [GOC:mah]"}
{"concept_id": "C1819571", "aliases": ["positive regulation of IL-23 production", "upregulation of interleukin-23 production", "up-regulation of interleukin-23 production", "up regulation of interleukin-23 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-23 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production. [GOC:mah]"}
{"concept_id": "C1819572", "aliases": ["up-regulation of interleukin-24 production", "positive regulation of IL-24 production", "up regulation of interleukin-24 production", "upregulation of interleukin-24 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-24 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production. [GOC:mah]"}
{"concept_id": "C1819573", "aliases": ["upregulation of interleukin-25 production", "up regulation of interleukin-25 production", "up-regulation of interleukin-25 production", "positive regulation of IL-25 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-25 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production. [GOC:mah]"}
{"concept_id": "C1819574", "aliases": ["up regulation of interleukin-26 production", "upregulation of interleukin-26 production", "positive regulation of IL-26 production", "up-regulation of interleukin-26 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-26 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production. [GOC:mah]"}
{"concept_id": "C1819575", "aliases": ["up-regulation of interleukin-27 production", "positive regulation of IL-27 production", "upregulation of interleukin-27 production", "up regulation of interleukin-27 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-27 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production. [GOC:mah]"}
{"concept_id": "C1819576", "aliases": ["up-regulation of interleukin-3 production", "upregulation of interleukin-3 production", "up regulation of interleukin-3 production", "positive regulation of IL-3 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-3 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production. [GOC:mah]"}
{"concept_id": "C1819577", "aliases": ["upregulation of interleukin-4 production", "up regulation of interleukin-4 production", "positive regulation of IL-4 production", "up-regulation of interleukin-4 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-4 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. [GOC:mah]"}
{"concept_id": "C1819578", "aliases": ["up-regulation of interleukin-5 production", "positive regulation of IL-5 production", "upregulation of interleukin-5 production", "up regulation of interleukin-5 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-5 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production. [GOC:mah]"}
{"concept_id": "C1819579", "aliases": ["positive regulation of IL-6 production", "up-regulation of interleukin-6 production", "up regulation of interleukin-6 production", "upregulation of interleukin-6 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-6 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]"}
{"concept_id": "C1819580", "aliases": ["up-regulation of interleukin-7 production", "upregulation of interleukin-7 production", "up regulation of interleukin-7 production", "positive regulation of IL-7 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-7 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production. [GOC:mah]"}
{"concept_id": "C1819581", "aliases": ["upregulation of interleukin-8 production", "up-regulation of interleukin-8 production", "positive regulation of IL-8 production", "up regulation of interleukin-8 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-8 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah]"}
{"concept_id": "C1819582", "aliases": ["up-regulation of interleukin-9 production", "up regulation of interleukin-9 production", "upregulation of interleukin-9 production", "positive regulation of IL-9 production"], "types": ["T040"], "canonical_name": "positive regulation of interleukin-9 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production. [GOC:mah]"}
{"concept_id": "C1819583", "aliases": ["upregulation of TRAIL production", "up-regulation of TRAIL production", "up regulation of TRAIL production"], "types": ["T040"], "canonical_name": "positive regulation of TRAIL production", "definition": "Any process that activates or increases the frequency, rate, or extent of TRAIL production. [GOC:mah]"}
{"concept_id": "C1819584", "aliases": ["positive regulation of TNF production", "positive regulation of tumor necrosis factor-alpha production", "positive regulation of TNF-alpha production", "upregulation of tumor necrosis factor production", "up regulation of tumor necrosis factor production", "up-regulation of tumor necrosis factor production"], "types": ["T040"], "canonical_name": "positive regulation of tumor necrosis factor production", "definition": "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]"}
{"concept_id": "C1819585", "aliases": ["up-regulation of lymphotoxin A production", "positive regulation of LTA production", "positive regulation of tumor necrosis factor-beta production", "positive regulation of lymphotoxin-alpha production", "positive regulation of TNF-beta production", "up regulation of lymphotoxin A production", "upregulation of lymphotoxin A production"], "types": ["T040"], "canonical_name": "positive regulation of lymphotoxin A production", "definition": "Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production. [GOC:mah]"}
{"concept_id": "C1819586", "aliases": [], "types": ["T040"], "canonical_name": "mast cell cytokine production", "definition": "Any process that contributes to cytokine production by a mast cell. [GOC:mah]"}
{"concept_id": "C1819590", "aliases": ["NHE3/E3KARP/ACTN4 complex location", "NHE3/E3KARP/alpha-actinin complex location", "NHE3/E3KARP/alpha-actinin complex"], "types": ["T026"], "canonical_name": "NHE3/E3KARP/ACTN4 complex", "definition": "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments. [PMID:11948184]"}
{"concept_id": "C1819591", "aliases": [], "types": ["T044"], "canonical_name": "copper-dependent protein binding", "definition": "Binding to a protein or protein complex, in the presence of copper. [GOC:ecd, PMID:16884690]"}
{"concept_id": "C1819592", "aliases": [], "types": ["T044"], "canonical_name": "regulation of monooxygenase activity", "definition": "Any process that modulates the activity of a monooxygenase. [GOC:mah]"}
{"concept_id": "C1819593", "aliases": ["down regulation of monooxygenase activity", "down-regulation of monooxygenase activity", "downregulation of monooxygenase activity"], "types": ["T044"], "canonical_name": "negative regulation of monooxygenase activity", "definition": "Any process that stops or reduces the activity of a monooxygenase. [GOC:mah]"}
{"concept_id": "C1819594", "aliases": ["upregulation of monooxygenase activity", "up regulation of monooxygenase activity", "up-regulation of monooxygenase activity"], "types": ["T044"], "canonical_name": "positive regulation of monooxygenase activity", "definition": "Any process that activates or increases the activity of a monooxygenase. [GOC:mah]"}
{"concept_id": "C1819595", "aliases": ["regulation of monophenol oxygenase activity", "regulation of monophenol monooxygenase activity"], "types": ["T044"], "canonical_name": "regulation of tyrosinase activity", "definition": "Any process that modulates the activity of a tyrosinase enzyme. [GOC:dph, GOC:mah, GOC:tb, PMID:2494997]"}
{"concept_id": "C1819596", "aliases": ["downregulation of monophenol oxygenase activity", "down-regulation of monophenol oxygenase activity", "negative regulation of monophenol monooxygenase activity", "down regulation of monophenol oxygenase activity", "negative regulation of monophenol oxygenase activity"], "types": ["T044"], "canonical_name": "negative regulation of tyrosinase activity", "definition": "Any process that stops or reduces the activity of a tyrosinase enzyme. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C1819597", "aliases": ["up regulation of monophenol oxygenase activity", "upregulation of monophenol oxygenase activity", "positive regulation of monophenol monooxygenase activity", "up-regulation of monophenol oxygenase activity", "positive regulation of monophenol oxygenase activity"], "types": ["T044"], "canonical_name": "positive regulation of tyrosinase activity", "definition": "Any process that activates or increases the activity of a tyrosinase enzyme monophenol oxygenase. [GOC:dph, GOC:mah, GOC:tb, PMID:2494997]"}
{"concept_id": "C1819598", "aliases": [], "types": ["T045"], "canonical_name": "DNA methylation on adenine", "definition": "The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule. [GOC:pf]"}
{"concept_id": "C1819599", "aliases": [], "types": ["T045"], "canonical_name": "adenine methylation"}
{"concept_id": "C1819600", "aliases": [], "types": ["T045"], "canonical_name": "DNA methylation on cytosine", "definition": "The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule. [GOC:pf]"}
{"concept_id": "C1819601", "aliases": [], "types": ["T045"], "canonical_name": "cytosine methylation"}
{"concept_id": "C1819602", "aliases": ["Piccolo NuA4 histone acetyltransferase complex location"], "types": ["T026"], "canonical_name": "Piccolo NuA4 histone acetyltransferase complex", "definition": "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p. [GOC:rb, PMID:12782659, PMID:15964809]"}
{"concept_id": "C1819603", "aliases": ["cobalt-transporting ATPase activity", "cobalt transporting ATPase activity", "ATP-dependent cobalt transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled cobalt transmembrane transporter activity"}
{"concept_id": "C1819605", "aliases": [], "types": ["T043"], "canonical_name": "copper-induced intracellular protein transport"}
{"concept_id": "C1819606", "aliases": ["down regulation of ATPase activity", "down-regulation of ATPase activity", "negative regulation of adenosinetriphosphatase activity", "downregulation of ATPase activity", "negative regulation of ATPase activity"], "types": ["T044"], "canonical_name": "negative regulation of ATP-dependent activity", "definition": "Any process that stops or reduces the rate of an ATP-dependent activity. [GOC:mah]"}
{"concept_id": "C1819607", "aliases": ["up regulation of ATPase activity", "positive regulation of ATPase activity", "positive regulation of adenosinetriphosphatase activity", "up-regulation of ATPase activity", "upregulation of ATPase activity"], "types": ["T044"], "canonical_name": "positive regulation of ATP-dependent activity", "definition": "Any process that activates or increases the rate of an ATP-dependent activity. [GOC:mah]"}
{"concept_id": "C1819608", "aliases": ["ELL-EAF complex location"], "types": ["T026"], "canonical_name": "ELL-EAF complex"}
{"concept_id": "C1819609", "aliases": [], "types": ["T045"], "canonical_name": "regulation of RNA elongation"}
{"concept_id": "C1819610", "aliases": ["regulation of DNA-dependent transcription, elongation", "regulation of transcription elongation, DNA-dependent"], "types": ["T045"], "canonical_name": "regulation of DNA-templated transcription, elongation", "definition": "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1819611", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcriptional elongation"}
{"concept_id": "C1819612", "aliases": ["negative regulation of DNA-dependent transcription, elongation", "negative regulation of transcription elongation, DNA-dependent"], "types": ["T045"], "canonical_name": "negative regulation of DNA-templated transcription, elongation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1819613", "aliases": ["negative regulation of transcriptional elongation"], "types": ["T045"], "canonical_name": "negative regulation of transcription elongation"}
{"concept_id": "C1819615", "aliases": ["positive regulation of DNA-dependent transcription, elongation", "positive regulation of transcription elongation, DNA-dependent"], "types": ["T045"], "canonical_name": "positive regulation of DNA-templated transcription, elongation", "definition": "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C1819616", "aliases": ["positive regulation of transcriptional elongation"], "types": ["T045"], "canonical_name": "positive regulation of transcription elongation"}
{"concept_id": "C1819617", "aliases": ["monocarboxylic acid metabolism", "monocarboxylate metabolic process"], "types": ["T044"], "canonical_name": "monocarboxylic acid metabolic process", "definition": "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). [GOC:vk]"}
{"concept_id": "C1819618", "aliases": ["saturated monocarboxylic acid metabolism", "saturated monocarboxylate metabolic process"], "types": ["T044"], "canonical_name": "saturated monocarboxylic acid metabolic process", "definition": "The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds. [GOC:mah, GOC:vk]"}
{"concept_id": "C1819619", "aliases": ["unsaturated monocarboxylate metabolic process", "unsaturated monocarboxylic acid metabolism"], "types": ["T044"], "canonical_name": "unsaturated monocarboxylic acid metabolic process", "definition": "The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds. [GOC:mah, GOC:vk]"}
{"concept_id": "C1819620", "aliases": [], "types": ["T044"], "canonical_name": "ribosome disassembly", "definition": "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. [GOC:mah, GOC:vk]"}
{"concept_id": "C1819621", "aliases": [], "types": ["T044"], "canonical_name": "ribosome dissociation factor"}
{"concept_id": "C1819622", "aliases": [], "types": ["T044"], "canonical_name": "lead ion binding", "definition": "Binding to lead (Pb) ions. [GOC:mah]"}
{"concept_id": "C1819623", "aliases": ["inhibition of CREB transcription factor"], "types": ["T043"], "canonical_name": "negative regulation of CREB transcription factor activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB. [GOC:dph, GOC:ecd, GOC:tb]"}
{"concept_id": "C1819624", "aliases": [], "types": ["T043"], "canonical_name": "CREB inhibitor"}
{"concept_id": "C1819625", "aliases": ["activation of CREB transcription factor", "activation of CREB"], "types": ["T043"], "canonical_name": "positive regulation of CREB transcription factor activity", "definition": "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. [GOC:dph, GOC:ecd, GOC:tb]"}
{"concept_id": "C1819626", "aliases": [], "types": ["T043"], "canonical_name": "CREB activator"}
{"concept_id": "C1819627", "aliases": ["GAP binding"], "types": ["T044"], "canonical_name": "GTPase activating protein binding", "definition": "Binding to a GTPase activating protein. [GOC:nln]"}
{"concept_id": "C1819628", "aliases": [], "types": ["T044"], "canonical_name": "heterotrimeric G-protein binding", "definition": "Binding to a heterotrimeric G-protein. [GOC:nln]"}
{"concept_id": "C1819629", "aliases": ["uropod organization and biogenesis", "uropod organisation"], "types": ["T043"], "canonical_name": "uropod organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated. [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750]"}
{"concept_id": "C1819630", "aliases": ["survival motor neuron complex location", "SMN core complex location", "survival motor neuron complex", "SMN core complex", "SMN complex location"], "types": ["T026"], "definition": "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. [PMID:16434402, PMID:17023415]", "canonical_name": "SMN complex"}
{"concept_id": "C1819631", "aliases": ["Swi5-Sfr1 complex location", "Sae3-Mei5 complex", "Sae3-Mei5 complex location"], "types": ["T026"], "canonical_name": "Swi5-Sfr1 complex", "definition": "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces). [PMID:15620352, PMID:16921379]"}
{"concept_id": "C1819632", "aliases": ["Swi5 complex", "Swi5 complex location"], "types": ["T026"], "canonical_name": "Swi5 complex"}
{"concept_id": "C1819633", "aliases": ["low-density lipoprotein receptor metabolism", "low-density lipoprotein receptor metabolic process", "LDL receptor metabolic process"], "types": ["T044"], "canonical_name": "low-density lipoprotein receptor particle metabolic process", "definition": "The chemical reactions and pathways involving low-density lipoprotein receptors. [GOC:vk]"}
{"concept_id": "C1819635", "aliases": ["receptor breakdown", "receptor catabolism", "receptor degradation"], "types": ["T044"], "canonical_name": "receptor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:mah]"}
{"concept_id": "C1819636", "aliases": ["LDL receptor breakdown", "LDL receptor degradation", "low-density lipoprotein receptor catabolic process", "LDL receptor catabolism", "low-density lipoprotein receptor catabolism", "low-density lipoprotein receptor degradation", "low-density lipoprotein receptor breakdown", "LDL receptor catabolic process"], "types": ["T044"], "canonical_name": "low-density lipoprotein particle receptor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:mah]"}
{"concept_id": "C1819637", "aliases": ["regulation of LDLr catabolism", "regulation of low-density lipoprotein receptor breakdown", "regulation of low-density lipoprotein receptor catabolic process", "regulation of low-density lipoprotein receptor catabolism", "regulation of low-density lipoprotein receptor degradation", "regulation of LDLr catabolic process"], "types": ["T043"], "canonical_name": "regulation of low-density lipoprotein particle receptor catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors. [GOC:mah]"}
{"concept_id": "C1819640", "aliases": ["CTDK complex", "carboxy-terminal domain protein kinase complex location", "CTDK complex location"], "types": ["T026"], "canonical_name": "carboxy-terminal domain protein kinase complex", "definition": "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. [PMID:15047695, PMID:16721054, PMID:17079683]"}
{"concept_id": "C1819642", "aliases": ["DNA ligase IV-XRCC4 complex", "DNA ligase IV complex location", "DNA ligase IV-XRCC4 complex location"], "types": ["T026"], "canonical_name": "DNA ligase IV complex", "definition": "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p. [PMID:16314503]"}
{"concept_id": "C1819643", "aliases": [], "types": ["T042"], "canonical_name": "lacrimal gland development", "definition": "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. [GOC:ln]"}
{"concept_id": "C1819645", "aliases": ["SRE binding"], "types": ["T045"], "canonical_name": "sterol response element binding", "definition": "Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism. [GOC:vk, PMID:11994399]"}
{"concept_id": "C1819646", "aliases": ["down regulation of epinephrine secretion", "down-regulation of epinephrine secretion", "downregulation of epinephrine secretion", "negative regulation of adrenaline secretion"], "types": ["T043"], "canonical_name": "negative regulation of epinephrine secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine. [GOC:vk]"}
{"concept_id": "C1819647", "aliases": ["up-regulation of epinephrine secretion", "upregulation of epinephrine secretion", "positive regulation of adrenaline secretion", "up regulation of epinephrine secretion"], "types": ["T043"], "canonical_name": "positive regulation of epinephrine secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine. [GOC:vk]"}
{"concept_id": "C1819648", "aliases": ["TNF receptor superfamily binding"], "types": ["T044"], "canonical_name": "tumor necrosis factor receptor superfamily binding", "definition": "Binding to a member of the tumor necrosis factor receptor superfamily. [GOC:add]"}
{"concept_id": "C1819649", "aliases": ["regulation of NK cell activation"], "types": ["T043"], "canonical_name": "regulation of natural killer cell activation", "definition": "Any process that modulates the frequency, rate or extent of natural killer cell activation. [GOC:mah]"}
{"concept_id": "C1819650", "aliases": ["down-regulation of natural killer cell activation", "downregulation of natural killer cell activation", "negative regulation of NK cell activation", "down regulation of natural killer cell activation"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation. [GOC:mah]"}
{"concept_id": "C1819651", "aliases": ["up regulation of natural killer cell activation", "up-regulation of natural killer cell activation", "positive regulation of NK cell activation", "upregulation of natural killer cell activation"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer cell activation. [GOC:mah]"}
{"concept_id": "C1819652", "aliases": ["regulation of NK cell proliferation"], "types": ["T043"], "canonical_name": "regulation of natural killer cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of natural killer cell proliferation. [GOC:mah]"}
{"concept_id": "C1819653", "aliases": ["down-regulation of natural killer cell proliferation", "negative regulation of NK cell proliferation", "down regulation of natural killer cell proliferation", "downregulation of natural killer cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation. [GOC:mah]"}
{"concept_id": "C1819654", "aliases": ["upregulation of natural killer cell proliferation", "up regulation of natural killer cell proliferation", "positive regulation of NK cell proliferation", "up-regulation of natural killer cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation. [GOC:mah]"}
{"concept_id": "C1819655", "aliases": ["regulation of natural killer cell proliferation during immune response"], "types": ["T043"], "canonical_name": "regulation of NK cell proliferation during immune response"}
{"concept_id": "C1819656", "aliases": ["negative regulation of natural killer cell proliferation during immune response"], "types": ["T043"], "canonical_name": "negative regulation of NK cell proliferation during immune response"}
{"concept_id": "C1819657", "aliases": ["positive regulation of natural killer cell proliferation during immune response"], "types": ["T043"], "canonical_name": "positive regulation of NK cell proliferation during immune response"}
{"concept_id": "C1819658", "aliases": ["regulation of NK cell differentiation"], "types": ["T043"], "canonical_name": "regulation of natural killer cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of natural killer cell differentiation. [GOC:mah]"}
{"concept_id": "C1819659", "aliases": ["downregulation of natural killer cell differentiation", "down regulation of natural killer cell differentiation", "down-regulation of natural killer cell differentiation", "negative regulation of NK cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation. [GOC:mah]"}
{"concept_id": "C1819660", "aliases": ["positive regulation of NK cell differentiation", "up-regulation of natural killer cell differentiation", "up regulation of natural killer cell differentiation", "upregulation of natural killer cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation. [GOC:mah]"}
{"concept_id": "C1819661", "aliases": ["regulation of natural killer cell differentiation during immune response"], "types": ["T043"], "canonical_name": "regulation of NK cell differentiation during immune response"}
{"concept_id": "C1819662", "aliases": ["negative regulation of natural killer cell differentiation during immune response"], "types": ["T043"], "canonical_name": "negative regulation of NK cell differentiation during immune response"}
{"concept_id": "C1819663", "aliases": ["positive regulation of natural killer cell differentiation during immune response"], "types": ["T043"], "canonical_name": "positive regulation of NK cell differentiation during immune response"}
{"concept_id": "C1819664", "aliases": ["regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation", "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation", "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation"], "types": ["T043"], "canonical_name": "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. [GOC:mah]"}
{"concept_id": "C1819665", "aliases": ["down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation", "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation", "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation", "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. [GOC:mah]"}
{"concept_id": "C1819666", "aliases": ["up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation", "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation", "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation", "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. [GOC:mah]"}
{"concept_id": "C1819667", "aliases": ["regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response", "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response", "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response"], "types": ["T043"], "canonical_name": "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response"}
{"concept_id": "C1819668", "aliases": ["negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response", "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response", "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response"], "types": ["T043"], "canonical_name": "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response"}
{"concept_id": "C1819670", "aliases": ["glomerular development"], "types": ["T042"], "canonical_name": "glomerulus development", "definition": "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. [GOC:mah, GOC:mtg_kidney_jan10]"}
{"concept_id": "C1819671", "aliases": [], "types": ["T043"], "canonical_name": "glomerular basement membrane development", "definition": "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration. [GOC:sr]"}
{"concept_id": "C1819672", "aliases": [], "types": ["T043"], "canonical_name": "distributive segregation", "definition": "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a backup mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally. [GOC:expert_rsh, GOC:ma, GOC:sart]"}
{"concept_id": "C1819673", "aliases": [], "types": ["T026"], "canonical_name": "plasma membrane bounded cell projection cytoplasm", "definition": "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. [GOC:krc, GOC:mah]"}
{"concept_id": "C1819674", "aliases": ["dendrite cytoplasm"], "types": ["T026"], "definition": "All of the contents of a dendrite, excluding the surrounding plasma membrane. [GOC:mah]", "canonical_name": "dendritic cytoplasm"}
{"concept_id": "C1819675", "aliases": ["intramolecular proline-rich region binding"], "types": ["T044"], "canonical_name": "intramolecular proline-rich ligand binding", "definition": "Binding to a proline-rich region within the same polypeptide. [GOC:pf]"}
{"concept_id": "C1819676", "aliases": [], "types": ["T044"], "canonical_name": "calcitonin binding", "definition": "Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid. [GOC:ecd]"}
{"concept_id": "C1819679", "aliases": ["microRNA metabolic process"], "types": ["T045"], "canonical_name": "miRNA metabolic process", "definition": "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. [PMID:17993620]"}
{"concept_id": "C1819680", "aliases": [], "types": ["T038"], "canonical_name": "hermaphrodite genitalia development", "definition": "The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures. [GOC:ems, ISBN:0140512888]"}
{"concept_id": "C1819682", "aliases": [], "types": ["T043"], "canonical_name": "glial cell growth", "definition": "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. [GOC:dph, GOC:isa_complete, GOC:jid]"}
{"concept_id": "C1819683", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in gastrulation", "definition": "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437]"}
{"concept_id": "C1819684", "aliases": ["GPI/GSI anchor metabolic process"], "types": ["T044"], "canonical_name": "GPI/GSI anchor metabolic process", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]"}
{"concept_id": "C1819686", "aliases": [], "types": ["T045"], "canonical_name": "D-loop biosynthesis"}
{"concept_id": "C1819687", "aliases": ["ribosomal large subunit biogenesis and assembly"], "types": ["T043"], "canonical_name": "ribosomal large subunit biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. [GOC:jl]"}
{"concept_id": "C1819688", "aliases": ["ribosomal small subunit biogenesis and assembly"], "types": ["T043"], "canonical_name": "ribosomal small subunit biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. [GOC:jl]"}
{"concept_id": "C1819689", "aliases": ["purine metabolic process"], "types": ["T044"], "canonical_name": "purine metabolic process", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C1819690", "aliases": [], "types": ["T044"], "canonical_name": "guiding stereospecific synthesis activity", "definition": "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis. [GOC:ma]"}
{"concept_id": "C1819691", "aliases": ["cholecalciferol metabolic process", "vitamin D3 metabolism", "calciol metabolic process"], "types": ["T044"], "canonical_name": "vitamin D3 metabolic process", "definition": "The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol. [GOC:BHF, GOC:mah]"}
{"concept_id": "C1819693", "aliases": [], "types": ["T044"], "canonical_name": "alpha-tocopherol metabolic process"}
{"concept_id": "C1819695", "aliases": ["ergocalciferol biosynthetic process"], "types": ["T044"], "canonical_name": "ergocalciferol biosynthetic process"}
{"concept_id": "C1819696", "aliases": ["naphthoquinone metabolic process"], "types": ["T044"], "canonical_name": "naphthoquinone metabolic process"}
{"concept_id": "C1819697", "aliases": ["myosin III complex location"], "types": ["T026"], "canonical_name": "myosin III complex", "definition": "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain. [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]"}
{"concept_id": "C1819699", "aliases": [], "types": ["T044"], "canonical_name": "taxol metabolic process"}
{"concept_id": "C1819700", "aliases": [], "types": ["T044"], "canonical_name": "taxol biosynthetic process"}
{"concept_id": "C1819701", "aliases": [], "types": ["T044"], "canonical_name": "PHA metabolic process"}
{"concept_id": "C1819702", "aliases": [], "types": ["T044"], "canonical_name": "PHA biosynthetic process"}
{"concept_id": "C1819703", "aliases": [], "types": ["T040"], "canonical_name": "anagen", "definition": "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair. [PMID:12230507]"}
{"concept_id": "C1819704", "aliases": ["active immune evasion via regulation of host complement system", "active immune evasion via modulation of host complement system", "active evasion of host immune response via regulation of host complement system"], "types": ["T040"], "canonical_name": "evasion of host immune response via regulation of host complement system", "definition": "Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction. [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]"}
{"concept_id": "C1819705", "aliases": ["active immune evasion via modulation of antigen processing/presentation", "active evasion of host immune response via regulation of host antigen processing and presentation", "active immune evasion via modulation of antigen processing and presentation", "active evasion of host immune response via regulation of host antigen processing and presentation pathway", "active immune evasion via regulation of antigen processing and presentation"], "types": ["T040"], "canonical_name": "evasion of host immune response via regulation of host antigen processing and presentation", "definition": "Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:12439615]"}
{"concept_id": "C1819708", "aliases": ["isoform-specific homophilic binding"], "types": ["T044"], "canonical_name": "identical protein binding", "definition": "Binding to an identical protein or proteins. [GOC:jl]"}
{"concept_id": "C1819709", "aliases": ["dihydric alcohol metabolic process", "diol metabolism"], "types": ["T044"], "canonical_name": "diol metabolic process", "definition": "The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. [GOC:curators]"}
{"concept_id": "C1819710", "aliases": ["diol biosynthesis", "diol formation", "dihydric alcohol biosynthetic process", "diol anabolism", "diol synthesis"], "types": ["T044"], "canonical_name": "diol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms. [GOC:mah]"}
{"concept_id": "C1819711", "aliases": ["dihydric alcohol catabolic process", "diol degradation", "diol breakdown", "diol catabolism"], "types": ["T044"], "canonical_name": "diol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms. [GOC:mah]"}
{"concept_id": "C1819712", "aliases": [], "types": ["T043"], "canonical_name": "cysteine transport", "definition": "The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1819714", "aliases": ["two-component system sensor activity"], "types": ["T044"], "canonical_name": "two-component sensor activity"}
{"concept_id": "C1819716", "aliases": [], "types": ["T028"], "definition": "The genetic complement of MITOCHONDRIA as represented in their DNA.", "canonical_name": "mitochondrial genome"}
{"concept_id": "C1819717", "aliases": ["mitochondrial DNA", "mtDNA"], "types": ["T026"], "canonical_name": "mitochondrial DNA location"}
{"concept_id": "C1819718", "aliases": ["regulation of B-lymphocyte mediated immunity", "regulation of B-cell mediated immunity", "regulation of B lymphocyte mediated immunity"], "types": ["T038"], "canonical_name": "regulation of B cell mediated immunity", "definition": "Any process that modulates the frequency, rate, or extent of B cell mediated immunity. [GOC:add]"}
{"concept_id": "C1819719", "aliases": ["down-regulation of B cell mediated immunity", "down regulation of B cell mediated immunity", "downregulation of B cell mediated immunity", "negative regulation of B-lymphocyte mediated immunity", "negative regulation of B-cell mediated immunity", "negative regulation of B lymphocyte mediated immunity"], "types": ["T040"], "canonical_name": "negative regulation of B cell mediated immunity", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity. [GOC:add]"}
{"concept_id": "C1819720", "aliases": ["up-regulation of B cell mediated immunity", "positive regulation of B-cell mediated immunity", "upregulation of B cell mediated immunity", "positive regulation of B-lymphocyte mediated immunity", "up regulation of B cell mediated immunity", "positive regulation of B lymphocyte mediated immunity"], "types": ["T040"], "canonical_name": "positive regulation of B cell mediated immunity", "definition": "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. [GOC:add]"}
{"concept_id": "C1819721", "aliases": ["regulation of NK cell mediated immunity"], "types": ["T038"], "canonical_name": "regulation of natural killer cell mediated immunity", "definition": "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. [GOC:add]"}
{"concept_id": "C1819722", "aliases": [], "types": ["T043"], "canonical_name": "regulation of natural killer cell activity"}
{"concept_id": "C1819723", "aliases": ["downregulation of natural killer cell mediated immunity", "negative regulation of NK cell mediated immunity", "down-regulation of natural killer cell mediated immunity", "down regulation of natural killer cell mediated immunity"], "types": ["T039"], "canonical_name": "negative regulation of natural killer cell mediated immunity", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. [GOC:add]"}
{"concept_id": "C1819724", "aliases": ["negative regulation of NK cell activity"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell activity"}
{"concept_id": "C1819725", "aliases": ["up regulation of natural killer cell mediated immunity", "upregulation of natural killer cell mediated immunity", "up-regulation of natural killer cell mediated immunity", "positive regulation of NK cell mediated immunity"], "types": ["T039"], "canonical_name": "positive regulation of natural killer cell mediated immunity", "definition": "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. [GOC:add]"}
{"concept_id": "C1819726", "aliases": ["positive regulation of NK cell activity"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell activity"}
{"concept_id": "C1819727", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cytokine production during immune response"}
{"concept_id": "C1819728", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cytokine production during immune response"}
{"concept_id": "C1819729", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of cytokine production during immune response"}
{"concept_id": "C1819730", "aliases": ["regulation of B-lymphocyte cytokine production", "regulation of B-cell cytokine production", "regulation of B lymphocyte cytokine production"], "types": ["T043"], "canonical_name": "regulation of B cell cytokine production", "definition": "Any process that modulates the frequency, rate, or extent of B cell cytokine production. [GOC:add]"}
{"concept_id": "C1819731", "aliases": ["downregulation of B cell cytokine production", "negative regulation of B-cell cytokine production", "down-regulation of B cell cytokine production", "negative regulation of B-lymphocyte cytokine production", "negative regulation of B lymphocyte cytokine production", "down regulation of B cell cytokine production"], "types": ["T043"], "canonical_name": "negative regulation of B cell cytokine production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production. [GOC:add]"}
{"concept_id": "C1819732", "aliases": ["positive regulation of B lymphocyte cytokine production", "positive regulation of B-cell cytokine production", "up-regulation of B cell cytokine production", "up regulation of B cell cytokine production", "positive regulation of B-lymphocyte cytokine production", "upregulation of B cell cytokine production"], "types": ["T043"], "canonical_name": "positive regulation of B cell cytokine production", "definition": "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production. [GOC:add]"}
{"concept_id": "C1819733", "aliases": ["regulation of T-cell cytokine production", "regulation of T lymphocyte cytokine production", "regulation of T-lymphocyte cytokine production"], "types": ["T043"], "canonical_name": "regulation of T cell cytokine production", "definition": "Any process that modulates the frequency, rate, or extent of T cell cytokine production. [GOC:add]"}
{"concept_id": "C1819734", "aliases": ["down regulation of T cell cytokine production", "negative regulation of T lymphocyte cytokine production", "negative regulation of T-lymphocyte cytokine production", "downregulation of T cell cytokine production", "down-regulation of T cell cytokine production", "negative regulation of T-cell cytokine production"], "types": ["T043"], "canonical_name": "negative regulation of T cell cytokine production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. [GOC:add]"}
{"concept_id": "C1819735", "aliases": ["positive regulation of T lymphocyte cytokine production", "upregulation of T cell cytokine production", "up regulation of T cell cytokine production", "positive regulation of T-cell cytokine production", "up-regulation of T cell cytokine production", "positive regulation of T-lymphocyte cytokine production"], "types": ["T043"], "canonical_name": "positive regulation of T cell cytokine production", "definition": "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. [GOC:add]"}
{"concept_id": "C1819736", "aliases": ["regulation of NK cell cytokine production"], "types": ["T043"], "canonical_name": "regulation of natural killer cell cytokine production", "definition": "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production. [GOC:add]"}
{"concept_id": "C1819737", "aliases": ["down-regulation of natural killer cell cytokine production", "downregulation of natural killer cell cytokine production", "negative regulation of NK cell cytokine production", "down regulation of natural killer cell cytokine production"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell cytokine production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production. [GOC:add]"}
{"concept_id": "C1819738", "aliases": ["up regulation of natural killer cell cytokine production", "up-regulation of natural killer cell cytokine production", "positive regulation of NK cell cytokine production", "upregulation of natural killer cell cytokine production"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell cytokine production", "definition": "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production. [GOC:add]"}
{"concept_id": "C1819739", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendritic cell cytokine production", "definition": "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production. [GOC:add]"}
{"concept_id": "C1819740", "aliases": ["down-regulation of dendritic cell cytokine production", "downregulation of dendritic cell cytokine production", "down regulation of dendritic cell cytokine production"], "types": ["T043"], "canonical_name": "negative regulation of dendritic cell cytokine production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production. [GOC:add]"}
{"concept_id": "C1819741", "aliases": ["up-regulation of dendritic cell cytokine production", "up regulation of dendritic cell cytokine production", "upregulation of dendritic cell cytokine production"], "types": ["T043"], "canonical_name": "positive regulation of dendritic cell cytokine production", "definition": "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production. [GOC:add]"}
{"concept_id": "C1819742", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myeloid dendritic cell cytokine production", "definition": "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production. [GOC:add]"}
{"concept_id": "C1819743", "aliases": ["down-regulation of myeloid dendritic cell cytokine production", "downregulation of myeloid dendritic cell cytokine production", "down regulation of myeloid dendritic cell cytokine production"], "types": ["T043"], "canonical_name": "negative regulation of myeloid dendritic cell cytokine production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production. [GOC:add]"}
{"concept_id": "C1819744", "aliases": ["up-regulation of myeloid dendritic cell cytokine production", "up regulation of myeloid dendritic cell cytokine production", "upregulation of myeloid dendritic cell cytokine production"], "types": ["T043"], "canonical_name": "positive regulation of myeloid dendritic cell cytokine production", "definition": "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production. [GOC:add]"}
{"concept_id": "C1819745", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plasmacytoid dendritic cell cytokine production", "definition": "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production. [GOC:add]"}
{"concept_id": "C1819746", "aliases": ["down regulation of plasmacytoid dendritic cell cytokine production", "downregulation of plasmacytoid dendritic cell cytokine production", "down-regulation of plasmacytoid dendritic cell cytokine production"], "types": ["T043"], "canonical_name": "negative regulation of plasmacytoid dendritic cell cytokine production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production. [GOC:add]"}
{"concept_id": "C1819747", "aliases": ["upregulation of plasmacytoid dendritic cell cytokine production", "up-regulation of plasmacytoid dendritic cell cytokine production", "up regulation of plasmacytoid dendritic cell cytokine production"], "types": ["T043"], "canonical_name": "positive regulation of plasmacytoid dendritic cell cytokine production", "definition": "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production. [GOC:add]"}
{"concept_id": "C1819754", "aliases": [], "types": ["T043"], "canonical_name": "antigen processing and presentation initiated by receptor mediated uptake of antigen", "definition": "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1819755", "aliases": [], "types": ["T043"], "canonical_name": "antigen processing and presentation following pinocytosis", "definition": "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1819756", "aliases": [], "types": ["T043"], "canonical_name": "antigen processing and presentation following phagocytosis", "definition": "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1819757", "aliases": ["antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen", "antigen processing and presentation initiated by PRR mediated uptake of antigen"], "types": ["T043"], "canonical_name": "antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen", "definition": "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR). [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1819758", "aliases": ["antigen processing and presentation initiated by TLR mediated phagocytosis of antigen"], "types": ["T043"], "canonical_name": "antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen", "definition": "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR). [GOC:add, ISBN:0781735149, PMID:15596122]"}
{"concept_id": "C1819759", "aliases": [], "types": ["T043"], "canonical_name": "antigen processing and presentation following macropinocytosis", "definition": "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis. [GOC:add, PMID:16556257]"}
{"concept_id": "C1819760", "aliases": [], "types": ["T043"], "canonical_name": "antigen processing and presentation following receptor mediated endocytosis", "definition": "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1819761", "aliases": ["cell surface pattern recognition receptor signalling pathway", "cell surface PRR signaling pathway", "cell surface pathogen receptor signaling pathway", "cell surface PAMP receptor signaling pathway"], "types": ["T044"], "canonical_name": "cell surface pattern recognition receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]"}
{"concept_id": "C1819762", "aliases": ["cytoplasmic pattern recognition receptor signalling pathway", "cytoplasmic PAMP receptor signaling pathway", "cytoplasmic PRR signaling pathway", "cytoplasmic pathogen receptor signaling pathway"], "types": ["T044"], "canonical_name": "cytoplasmic pattern recognition receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]"}
{"concept_id": "C1819763", "aliases": ["intracellular vesicle pattern recognition receptor signalling pathway", "intracellular vesicle PAMP receptor signaling pathway", "intracellular vesicle PRR signaling pathway", "intracellular vesicle pathogen receptor signaling pathway"], "types": ["T044"], "canonical_name": "intracellular vesicle pattern recognition receptor signaling pathway"}
{"concept_id": "C1819764", "aliases": ["MyD88-dependent TLR signaling pathway", "MyD88-dependent toll-like receptor signalling pathway"], "types": ["T044"], "canonical_name": "MyD88-dependent toll-like receptor signaling pathway", "definition": "A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]"}
{"concept_id": "C1819765", "aliases": ["MyD88-independent toll-like receptor signalling pathway", "MyD88-independent TLR signaling pathway"], "types": ["T044"], "canonical_name": "MyD88-independent toll-like receptor signaling pathway", "definition": "A toll-like receptor signaling pathway not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate an immune response. [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]"}
{"concept_id": "C1819766", "aliases": [], "types": ["T040"], "canonical_name": "immune response-activating signal transduction", "definition": "The series of molecular signals generated by a ligand binding to its receptor that ultimately lead to the activation or perpetuation of an immune response. [GOC:add]"}
{"concept_id": "C1819768", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antimicrobial humoral response", "definition": "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response. [GOC:add]"}
{"concept_id": "C1819769", "aliases": ["up-regulation of antimicrobial humoral response", "upregulation of antimicrobial humoral response", "up regulation of antimicrobial humoral response"], "types": ["T039"], "canonical_name": "positive regulation of antimicrobial humoral response", "definition": "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response. [GOC:add]"}
{"concept_id": "C1819770", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myeloid leukocyte differentiation", "definition": "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. [GOC:add]"}
{"concept_id": "C1819771", "aliases": ["down regulation of myeloid leukocyte differentiation", "downregulation of myeloid leukocyte differentiation", "down-regulation of myeloid leukocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of myeloid leukocyte differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. [GOC:add]"}
{"concept_id": "C1819772", "aliases": ["up-regulation of myeloid leukocyte differentiation", "up regulation of myeloid leukocyte differentiation", "upregulation of myeloid leukocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of myeloid leukocyte differentiation", "definition": "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. [GOC:add]"}
{"concept_id": "C1819774", "aliases": [], "types": ["T043"], "canonical_name": "immune response-inhibiting signal transduction", "definition": "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1819775", "aliases": [], "types": ["T043"], "canonical_name": "innate immune response-inhibiting signal transduction", "definition": "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response. [GOC:add, ISBN:0781735149, PMID:15771571]"}
{"concept_id": "C1819776", "aliases": ["immune response-inhibiting cell surface receptor signalling pathway"], "types": ["T044"], "canonical_name": "immune response-inhibiting cell surface receptor signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of inhibiting an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]"}
{"concept_id": "C1819777", "aliases": ["immune response-regulating cell surface receptor signalling pathway"], "types": ["T044"], "canonical_name": "immune response-regulating cell surface receptor signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]"}
{"concept_id": "C1819778", "aliases": ["NK cell inhibitory signaling pathway", "natural killer cell inhibitory signalling pathway"], "types": ["T044"], "canonical_name": "natural killer cell inhibitory signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]"}
{"concept_id": "C1819779", "aliases": [], "types": ["T044"], "canonical_name": "inhibitory KIR signaling pathway"}
{"concept_id": "C1819781", "aliases": ["T cell inhibitory signalling pathway", "T lymphocyte inhibitory signaling pathway", "T-cell inhibitory signaling pathway", "T-lymphocyte inhibitory signaling pathway"], "types": ["T044"], "canonical_name": "T cell inhibitory signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response. [GOC:add, PMID:15258309]"}
{"concept_id": "C1819782", "aliases": ["KIR signaling pathway", "killer cell inhibitory receptor signaling pathway", "inhibitory killer cell immunoglobulin-like receptor signalling pathway"], "types": ["T044"], "canonical_name": "inhibitory killer cell immunoglobulin-like receptor signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]"}
{"concept_id": "C1819783", "aliases": ["inhibitory C-type lectin receptor signalling pathway"], "types": ["T044"], "canonical_name": "inhibitory C-type lectin receptor signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]"}
{"concept_id": "C1819784", "aliases": ["Ly49 inhibitory receptor signaling pathway"], "types": ["T044"], "canonical_name": "Ly49 inhibitory receptor signaling pathway"}
{"concept_id": "C1819785", "aliases": ["B-cell inhibitory signaling pathway", "B cell inhibitory signalling pathway", "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway"], "types": ["T044"], "canonical_name": "B cell inhibitory signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response. [GOC:add, PMID:16413920]"}
{"concept_id": "C1819786", "aliases": ["Fc-receptor mediated inhibitory signaling pathway", "Fc receptor mediated inhibitory signalling pathway"], "types": ["T044"], "canonical_name": "Fc receptor mediated inhibitory signaling pathway", "definition": "The series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1819787", "aliases": [], "types": ["T038"], "canonical_name": "antimicrobial peptide production", "definition": "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]"}
{"concept_id": "C1819788", "aliases": [], "types": ["T043"], "canonical_name": "antimicrobial peptide secretion", "definition": "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]"}
{"concept_id": "C1819789", "aliases": [], "types": ["T044"], "canonical_name": "antimicrobial peptide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]"}
{"concept_id": "C1819790", "aliases": [], "types": ["T038"], "canonical_name": "antibacterial peptide production", "definition": "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]"}
{"concept_id": "C1819791", "aliases": [], "types": ["T043"], "canonical_name": "antibacterial peptide secretion", "definition": "The regulated release of an antibacterial peptide from a cell or a tissue. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]"}
{"concept_id": "C1819792", "aliases": [], "types": ["T044"], "canonical_name": "antibacterial peptide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an antibacterial peptide. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]"}
{"concept_id": "C1819793", "aliases": [], "types": ["T038"], "canonical_name": "antifungal peptide production", "definition": "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]"}
{"concept_id": "C1819794", "aliases": [], "types": ["T043"], "canonical_name": "antifungal peptide secretion", "definition": "The regulated release of an antifungal peptide from a cell or a tissue. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]"}
{"concept_id": "C1819795", "aliases": [], "types": ["T044"], "canonical_name": "antifungal peptide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an antifungal peptide. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]"}
{"concept_id": "C1819796", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antimicrobial peptide production", "definition": "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production. [GOC:add]"}
{"concept_id": "C1819797", "aliases": ["down regulation of antimicrobial peptide production", "down-regulation of antimicrobial peptide production", "downregulation of antimicrobial peptide production"], "types": ["T039"], "canonical_name": "negative regulation of antimicrobial peptide production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production. [GOC:add]"}
{"concept_id": "C1819798", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antibacterial peptide production", "definition": "Any process that modulates the frequency, rate, or extent of antibacterial peptide production. [GOC:add]"}
{"concept_id": "C1819799", "aliases": ["down-regulation of antibacterial peptide production", "downregulation of antibacterial peptide production", "down regulation of antibacterial peptide production"], "types": ["T039"], "canonical_name": "negative regulation of antibacterial peptide production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production. [GOC:add]"}
{"concept_id": "C1819800", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antifungal peptide production", "definition": "Any process that modulates the frequency, rate, or extent of antifungal peptide production. [GOC:add]"}
{"concept_id": "C1819801", "aliases": ["down-regulation of antifungal peptide production", "down regulation of antifungal peptide production", "downregulation of antifungal peptide production"], "types": ["T039"], "canonical_name": "negative regulation of antifungal peptide production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production. [GOC:add]"}
{"concept_id": "C1819802", "aliases": [], "types": ["T043"], "canonical_name": "peptide secretion", "definition": "The controlled release of a peptide from a cell or a tissue. [GOC:add]"}
{"concept_id": "C1819803", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peptide secretion", "definition": "Any process that modulates the frequency, rate, or extent of peptide secretion. [GOC:add]"}
{"concept_id": "C1819804", "aliases": ["down regulation of peptide secretion", "downregulation of peptide secretion", "down-regulation of peptide secretion"], "types": ["T043"], "canonical_name": "negative regulation of peptide secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. [GOC:add]"}
{"concept_id": "C1819805", "aliases": ["upregulation of peptide secretion", "up regulation of peptide secretion", "up-regulation of peptide secretion"], "types": ["T043"], "canonical_name": "positive regulation of peptide secretion", "definition": "Any process that activates or increases the frequency, rate, or extent of peptide secretion. [GOC:add]"}
{"concept_id": "C1819806", "aliases": [], "types": ["T043"], "canonical_name": "regulation of antimicrobial peptide secretion", "definition": "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion. [GOC:add]"}
{"concept_id": "C1819807", "aliases": ["down-regulation of antimicrobial peptide secretion", "downregulation of antimicrobial peptide secretion", "down regulation of antimicrobial peptide secretion"], "types": ["T043"], "canonical_name": "negative regulation of antimicrobial peptide secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion. [GOC:add]"}
{"concept_id": "C1819808", "aliases": ["up-regulation of antimicrobial peptide secretion", "upregulation of antimicrobial peptide secretion", "up regulation of antimicrobial peptide secretion"], "types": ["T043"], "canonical_name": "positive regulation of antimicrobial peptide secretion", "definition": "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion. [GOC:add]"}
{"concept_id": "C1819809", "aliases": [], "types": ["T043"], "canonical_name": "regulation of antibacterial peptide secretion", "definition": "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion. [GOC:add]"}
{"concept_id": "C1819810", "aliases": ["downregulation of antibacterial peptide secretion", "down regulation of antibacterial peptide secretion", "down-regulation of antibacterial peptide secretion"], "types": ["T043"], "canonical_name": "negative regulation of antibacterial peptide secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion. [GOC:add]"}
{"concept_id": "C1819811", "aliases": ["up regulation of antibacterial peptide secretion", "up-regulation of antibacterial peptide secretion", "upregulation of antibacterial peptide secretion"], "types": ["T043"], "canonical_name": "positive regulation of antibacterial peptide secretion", "definition": "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion. [GOC:add]"}
{"concept_id": "C1819812", "aliases": [], "types": ["T043"], "canonical_name": "regulation of antifungal peptide secretion", "definition": "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion. [GOC:add]"}
{"concept_id": "C1819813", "aliases": ["downregulation of antifungal peptide secretion", "down-regulation of antifungal peptide secretion", "down regulation of antifungal peptide secretion"], "types": ["T043"], "canonical_name": "negative regulation of antifungal peptide secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion. [GOC:add]"}
{"concept_id": "C1819814", "aliases": ["upregulation of antifungal peptide secretion", "up-regulation of antifungal peptide secretion", "up regulation of antifungal peptide secretion"], "types": ["T043"], "canonical_name": "positive regulation of antifungal peptide secretion", "definition": "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion. [GOC:add]"}
{"concept_id": "C1819815", "aliases": ["upregulation of antibacterial peptide production", "up-regulation of antibacterial peptide production", "up regulation of antibacterial peptide production"], "types": ["T039"], "canonical_name": "positive regulation of antibacterial peptide production", "definition": "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production. [GOC:add]"}
{"concept_id": "C1819816", "aliases": ["up-regulation of antifungal peptide production", "upregulation of antifungal peptide production", "up regulation of antifungal peptide production"], "types": ["T039"], "canonical_name": "positive regulation of antifungal peptide production", "definition": "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production. [GOC:add]"}
{"concept_id": "C1819817", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antimicrobial peptide biosynthetic process", "definition": "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis. [GOC:add]"}
{"concept_id": "C1819818", "aliases": ["down regulation of antimicrobial peptide biosynthetic process", "down-regulation of antimicrobial peptide biosynthetic process", "downregulation of antimicrobial peptide biosynthetic process"], "types": ["T039"], "canonical_name": "negative regulation of antimicrobial peptide biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis. [GOC:add]"}
{"concept_id": "C1819819", "aliases": ["upregulation of antimicrobial peptide biosynthetic process", "up-regulation of antimicrobial peptide biosynthetic process", "up regulation of antimicrobial peptide biosynthetic process"], "types": ["T039"], "canonical_name": "positive regulation of antimicrobial peptide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis. [GOC:add]"}
{"concept_id": "C1819820", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antibacterial peptide biosynthetic process", "definition": "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis. [GOC:add]"}
{"concept_id": "C1819821", "aliases": ["down-regulation of antibacterial peptide biosynthetic process", "down regulation of antibacterial peptide biosynthetic process", "downregulation of antibacterial peptide biosynthetic process"], "types": ["T039"], "canonical_name": "negative regulation of antibacterial peptide biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis. [GOC:add]"}
{"concept_id": "C1819822", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antifungal peptide biosynthetic process", "definition": "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis. [GOC:add]"}
{"concept_id": "C1819823", "aliases": ["down regulation of antifungal peptide biosynthetic process", "downregulation of antifungal peptide biosynthetic process", "down-regulation of antifungal peptide biosynthetic process"], "types": ["T039"], "canonical_name": "negative regulation of antifungal peptide biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis. [GOC:add]"}
{"concept_id": "C1819830", "aliases": ["intracellular defense response"], "types": ["T043"], "canonical_name": "intracellular defence response"}
{"concept_id": "C1819831", "aliases": [], "types": ["T040"], "canonical_name": "regulation of adaptive immune response", "definition": "Any process that modulates the frequency, rate, or extent of an adaptive immune response. [GOC:add]"}
{"concept_id": "C1819832", "aliases": ["downregulation of adaptive immune response", "down-regulation of adaptive immune response", "down regulation of adaptive immune response"], "types": ["T040"], "canonical_name": "negative regulation of adaptive immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. [GOC:add]"}
{"concept_id": "C1819833", "aliases": ["up regulation of adaptive immune response", "upregulation of adaptive immune response", "up-regulation of adaptive immune response"], "types": ["T040"], "canonical_name": "positive regulation of adaptive immune response", "definition": "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. [GOC:add]"}
{"concept_id": "C1819834", "aliases": [], "types": ["T040"], "canonical_name": "regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "definition": "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. [GOC:add, GOC:mtg_sensu]"}
{"concept_id": "C1819835", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. [GOC:add, GOC:mtg_sensu]"}
{"concept_id": "C1819836", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "definition": "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. [GOC:add, GOC:mtg_sensu]"}
{"concept_id": "C1819837", "aliases": [], "types": ["T040"], "canonical_name": "regulation of T-helper 1 type immune response", "definition": "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add]"}
{"concept_id": "C1819838", "aliases": ["downregulation of T-helper 1 type immune response", "down regulation of T-helper 1 type immune response", "down-regulation of T-helper 1 type immune response"], "types": ["T040"], "canonical_name": "negative regulation of T-helper 1 type immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add]"}
{"concept_id": "C1819839", "aliases": ["up-regulation of T-helper 1 type immune response", "upregulation of T-helper 1 type immune response", "up regulation of T-helper 1 type immune response"], "types": ["T040"], "canonical_name": "positive regulation of T-helper 1 type immune response", "definition": "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add]"}
{"concept_id": "C1819840", "aliases": ["regulation of Th2 immune response"], "types": ["T040"], "canonical_name": "regulation of T-helper 2 type immune response"}
{"concept_id": "C1819841", "aliases": ["negative regulation of Th2 immune response"], "types": ["T040"], "canonical_name": "negative regulation of T-helper 2 type immune response"}
{"concept_id": "C1819842", "aliases": ["positive regulation of Th2 immune response"], "types": ["T040"], "canonical_name": "positive regulation of T-helper 2 type immune response"}
{"concept_id": "C1819843", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to biotic stimulus", "definition": "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. [GOC:add]"}
{"concept_id": "C1819844", "aliases": ["down-regulation of response to biotic stimulus", "downregulation of response to biotic stimulus", "down regulation of response to biotic stimulus"], "types": ["T039"], "canonical_name": "negative regulation of response to biotic stimulus", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. [GOC:add]"}
{"concept_id": "C1819845", "aliases": ["up-regulation of response to biotic stimulus", "upregulation of response to biotic stimulus", "up regulation of response to biotic stimulus"], "types": ["T039"], "canonical_name": "positive regulation of response to biotic stimulus", "definition": "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. [GOC:add]"}
{"concept_id": "C1819846", "aliases": ["regulation of response to tumour cell"], "types": ["T039"], "canonical_name": "regulation of response to tumor cell", "definition": "Any process that modulates the frequency, rate, or extent of a response to tumor cell. [GOC:add]"}
{"concept_id": "C1819847", "aliases": ["downregulation of response to tumor cell", "negative regulation of response to tumour cell", "down regulation of response to tumor cell", "down-regulation of response to tumor cell"], "types": ["T039"], "canonical_name": "negative regulation of response to tumor cell", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell. [GOC:add]"}
{"concept_id": "C1819848", "aliases": ["up regulation of response to tumor cell", "positive regulation of response to tumour cell", "upregulation of response to tumor cell", "up-regulation of response to tumor cell"], "types": ["T039"], "canonical_name": "positive regulation of response to tumor cell", "definition": "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. [GOC:add]"}
{"concept_id": "C1819849", "aliases": ["regulation of immune response to tumour cell"], "types": ["T040"], "canonical_name": "regulation of immune response to tumor cell", "definition": "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell. [GOC:add]"}
{"concept_id": "C1819850", "aliases": ["down regulation of immune response to tumor cell", "down-regulation of immune response to tumor cell", "negative regulation of immune response to tumour cell", "downregulation of immune response to tumor cell"], "types": ["T040"], "canonical_name": "negative regulation of immune response to tumor cell", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell. [GOC:add]"}
{"concept_id": "C1819851", "aliases": ["upregulation of immune response to tumor cell", "up regulation of immune response to tumor cell", "up-regulation of immune response to tumor cell", "positive regulation of immune response to tumour cell"], "types": ["T040"], "canonical_name": "positive regulation of immune response to tumor cell", "definition": "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell. [GOC:add]"}
{"concept_id": "C1819852", "aliases": ["regulation of T lymphocyte mediated immune response to tumor cell", "regulation of T-lymphocyte mediated immune response to tumor cell", "regulation of T-cell mediated immune response to tumor cell", "regulation of T cell mediated immune response to tumour cell"], "types": ["T040"], "canonical_name": "regulation of T cell mediated immune response to tumor cell", "definition": "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell. [GOC:add]"}
{"concept_id": "C1819853", "aliases": ["negative regulation of T cell mediated immune response to tumour cell", "down regulation of T cell mediated immune response to tumor cell", "negative regulation of T-lymphocyte mediated immune response to tumor cell", "negative regulation of T-cell mediated immune response to tumor cell", "negative regulation of T lymphocyte mediated immune response to tumor cell", "downregulation of T cell mediated immune response to tumor cell", "down-regulation of T cell mediated immune response to tumor cell"], "types": ["T043"], "canonical_name": "negative regulation of T cell mediated immune response to tumor cell", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell. [GOC:add]"}
{"concept_id": "C1819854", "aliases": ["positive regulation of T-lymphocyte mediated immune response to tumor cell", "positive regulation of T cell mediated immune response to tumour cell", "positive regulation of T-cell mediated immune response to tumor cell", "positive regulation of T lymphocyte mediated immune response to tumor cell", "up regulation of T cell mediated immune response to tumor cell", "up-regulation of T cell mediated immune response to tumor cell", "upregulation of T cell mediated immune response to tumor cell"], "types": ["T040"], "canonical_name": "positive regulation of T cell mediated immune response to tumor cell", "definition": "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell. [GOC:add]"}
{"concept_id": "C1819855", "aliases": ["regulation of tolerance induction to tumour cell"], "types": ["T040"], "canonical_name": "regulation of tolerance induction to tumor cell", "definition": "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell. [GOC:add]"}
{"concept_id": "C1819856", "aliases": ["negative regulation of tolerance induction to tumour cell", "downregulation of tolerance induction to tumor cell", "down regulation of tolerance induction to tumor cell", "down-regulation of tolerance induction to tumor cell"], "types": ["T040"], "canonical_name": "negative regulation of tolerance induction to tumor cell", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell. [GOC:add]"}
{"concept_id": "C1819857", "aliases": ["up regulation of tolerance induction to tumor cell", "up-regulation of tolerance induction to tumor cell", "upregulation of tolerance induction to tumor cell", "positive regulation of tolerance induction to tumour cell"], "types": ["T040"], "canonical_name": "positive regulation of tolerance induction to tumor cell", "definition": "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell. [GOC:add]"}
{"concept_id": "C1819858", "aliases": [], "types": ["T040"], "canonical_name": "regulation of T cell tolerance induction to tumor cell", "definition": "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell. [GOC:add]"}
{"concept_id": "C1819859", "aliases": ["down-regulation of T cell tolerance induction to tumor cell", "down regulation of T cell tolerance induction to tumor cell", "downregulation of T cell tolerance induction to tumor cell"], "types": ["T043"], "canonical_name": "negative regulation of T cell tolerance induction to tumor cell", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell. [GOC:add]"}
{"concept_id": "C1819860", "aliases": ["up-regulation of T cell tolerance induction to tumor cell", "upregulation of T cell tolerance induction to tumor cell", "up regulation of T cell tolerance induction to tumor cell"], "types": ["T040"], "canonical_name": "positive regulation of T cell tolerance induction to tumor cell", "definition": "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell. [GOC:add]"}
{"concept_id": "C1819861", "aliases": [], "types": ["T040"], "canonical_name": "regulation of peripheral T cell tolerance induction", "definition": "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction. [GOC:add]"}
{"concept_id": "C1819862", "aliases": ["down regulation of peripheral T cell tolerance induction", "downregulation of peripheral T cell tolerance induction", "down-regulation of peripheral T cell tolerance induction"], "types": ["T040"], "canonical_name": "negative regulation of peripheral T cell tolerance induction", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction. [GOC:add]"}
{"concept_id": "C1819863", "aliases": ["up-regulation of peripheral T cell tolerance induction", "up regulation of peripheral T cell tolerance induction", "upregulation of peripheral T cell tolerance induction"], "types": ["T040"], "canonical_name": "positive regulation of peripheral T cell tolerance induction", "definition": "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction. [GOC:add]"}
{"concept_id": "C1819864", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T cell mediated cytotoxicity directed against tumor cell target", "definition": "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target. [GOC:add]"}
{"concept_id": "C1819865", "aliases": ["downregulation of T cell mediated cytotoxicity directed against tumor cell target", "down regulation of T cell mediated cytotoxicity directed against tumor cell target", "down-regulation of T cell mediated cytotoxicity directed against tumor cell target"], "types": ["T043"], "canonical_name": "negative regulation of T cell mediated cytotoxicity directed against tumor cell target", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target. [GOC:add]"}
{"concept_id": "C1819866", "aliases": ["upregulation of T cell mediated cytotoxicity directed against tumor cell target", "up-regulation of T cell mediated cytotoxicity directed against tumor cell target", "up regulation of T cell mediated cytotoxicity directed against tumor cell target"], "types": ["T043"], "canonical_name": "positive regulation of T cell mediated cytotoxicity directed against tumor cell target", "definition": "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target. [GOC:add]"}
{"concept_id": "C1819867", "aliases": [], "types": ["T040"], "canonical_name": "regulation of natural killer cell mediated immune response to tumor cell", "definition": "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. [GOC:add]"}
{"concept_id": "C1819868", "aliases": ["down-regulation of natural killer cell mediated immune response to tumor cell", "down regulation of natural killer cell mediated immune response to tumor cell", "downregulation of natural killer cell mediated immune response to tumor cell"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell mediated immune response to tumor cell", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. [GOC:add]"}
{"concept_id": "C1819869", "aliases": ["up-regulation of natural killer cell mediated immune response to tumor cell", "up regulation of natural killer cell mediated immune response to tumor cell", "upregulation of natural killer cell mediated immune response to tumor cell"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell mediated immune response to tumor cell", "definition": "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. [GOC:add]"}
{"concept_id": "C1819870", "aliases": [], "types": ["T043"], "canonical_name": "regulation of natural killer cell mediated cytotoxicity directed against tumor cell target", "definition": "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. [GOC:add]"}
{"concept_id": "C1819871", "aliases": ["down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target", "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target", "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. [GOC:add]"}
{"concept_id": "C1819872", "aliases": ["up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target", "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target", "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target", "definition": "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. [GOC:add]"}
{"concept_id": "C1819873", "aliases": [], "types": ["T046"], "canonical_name": "regulation of inflammatory response to antigenic stimulus", "definition": "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819874", "aliases": ["down-regulation of inflammatory response to antigenic stimulus", "downregulation of inflammatory response to antigenic stimulus", "down regulation of inflammatory response to antigenic stimulus"], "types": ["T040"], "canonical_name": "negative regulation of inflammatory response to antigenic stimulus", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819875", "aliases": ["upregulation of inflammatory response to antigenic stimulus", "up-regulation of inflammatory response to antigenic stimulus", "up regulation of inflammatory response to antigenic stimulus"], "types": ["T040"], "canonical_name": "positive regulation of inflammatory response to antigenic stimulus", "definition": "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819876", "aliases": [], "types": ["T046"], "canonical_name": "regulation of acute inflammatory response to antigenic stimulus", "definition": "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819877", "aliases": ["downregulation of acute inflammatory response to antigenic stimulus", "down regulation of acute inflammatory response to antigenic stimulus", "down-regulation of acute inflammatory response to antigenic stimulus"], "types": ["T040"], "canonical_name": "negative regulation of acute inflammatory response to antigenic stimulus", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819878", "aliases": ["up regulation of acute inflammatory response to antigenic stimulus", "up-regulation of acute inflammatory response to antigenic stimulus", "upregulation of acute inflammatory response to antigenic stimulus"], "types": ["T040"], "canonical_name": "positive regulation of acute inflammatory response to antigenic stimulus", "definition": "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819879", "aliases": ["regulation of B-lymphocyte deletion", "regulation of B-cell deletion", "regulation of B lymphocyte deletion"], "types": ["T043"], "canonical_name": "regulation of B cell deletion", "definition": "Any process that modulates the frequency, rate, or extent of B cell deletion. [GOC:add]"}
{"concept_id": "C1819880", "aliases": ["downregulation of B cell deletion", "negative regulation of B-lymphocyte deletion", "down-regulation of B cell deletion", "negative regulation of B lymphocyte deletion", "negative regulation of B-cell deletion", "down regulation of B cell deletion"], "types": ["T043"], "canonical_name": "negative regulation of B cell deletion", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion. [GOC:add]"}
{"concept_id": "C1819881", "aliases": ["up-regulation of B cell deletion", "upregulation of B cell deletion", "positive regulation of B lymphocyte deletion", "positive regulation of B-cell deletion", "up regulation of B cell deletion", "positive regulation of B-lymphocyte deletion"], "types": ["T043"], "canonical_name": "positive regulation of B cell deletion", "definition": "Any process that activates or increases the frequency, rate, or extent of B cell deletion. [GOC:add]"}
{"concept_id": "C1819882", "aliases": ["T-lymphocyte anergy", "T lymphocyte anergy", "T-cell anergy"], "types": ["T038"], "canonical_name": "T cell anergy", "definition": "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C1819883", "aliases": ["regulation of NK cell tolerance induction"], "types": ["T043"], "canonical_name": "regulation of natural killer cell tolerance induction", "definition": "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction. [GOC:add]"}
{"concept_id": "C1819884", "aliases": ["negative regulation of NK cell tolerance induction", "down-regulation of natural killer cell tolerance induction", "downregulation of natural killer cell tolerance induction", "down regulation of natural killer cell tolerance induction"], "types": ["T039"], "canonical_name": "negative regulation of natural killer cell tolerance induction", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction. [GOC:add]"}
{"concept_id": "C1819885", "aliases": ["upregulation of natural killer cell tolerance induction", "up-regulation of natural killer cell tolerance induction", "positive regulation of NK cell tolerance induction", "up regulation of natural killer cell tolerance induction"], "types": ["T039"], "canonical_name": "positive regulation of natural killer cell tolerance induction", "definition": "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction. [GOC:add]"}
{"concept_id": "C1819886", "aliases": [], "types": ["T046"], "canonical_name": "regulation of chronic inflammatory response to antigenic stimulus", "definition": "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819887", "aliases": ["down regulation of chronic inflammatory response to antigenic stimulus", "down-regulation of chronic inflammatory response to antigenic stimulus", "downregulation of chronic inflammatory response to antigenic stimulus"], "types": ["T040"], "canonical_name": "negative regulation of chronic inflammatory response to antigenic stimulus", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819888", "aliases": ["up-regulation of chronic inflammatory response to antigenic stimulus", "upregulation of chronic inflammatory response to antigenic stimulus", "up regulation of chronic inflammatory response to antigenic stimulus"], "types": ["T040"], "canonical_name": "positive regulation of chronic inflammatory response to antigenic stimulus", "definition": "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819889", "aliases": [], "types": ["T046"], "canonical_name": "regulation of acute inflammatory response to non-antigenic stimulus", "definition": "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819890", "aliases": ["downregulation of acute inflammatory response to non-antigenic stimulus", "down-regulation of acute inflammatory response to non-antigenic stimulus", "down regulation of acute inflammatory response to non-antigenic stimulus"], "types": ["T040"], "canonical_name": "negative regulation of acute inflammatory response to non-antigenic stimulus", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819891", "aliases": ["up-regulation of acute inflammatory response to non-antigenic stimulus", "up regulation of acute inflammatory response to non-antigenic stimulus", "upregulation of acute inflammatory response to non-antigenic stimulus"], "types": ["T040"], "canonical_name": "positive regulation of acute inflammatory response to non-antigenic stimulus", "definition": "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819892", "aliases": [], "types": ["T046"], "canonical_name": "regulation of chronic inflammatory response to non-antigenic stimulus", "definition": "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819893", "aliases": ["down regulation of chronic inflammatory response to non-antigenic stimulus", "downregulation of chronic inflammatory response to non-antigenic stimulus", "down-regulation of chronic inflammatory response to non-antigenic stimulus"], "types": ["T040"], "canonical_name": "negative regulation of chronic inflammatory response to non-antigenic stimulus", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819894", "aliases": ["up regulation of chronic inflammatory response to non-antigenic stimulus", "up-regulation of chronic inflammatory response to non-antigenic stimulus", "upregulation of chronic inflammatory response to non-antigenic stimulus"], "types": ["T040"], "canonical_name": "positive regulation of chronic inflammatory response to non-antigenic stimulus", "definition": "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus. [GOC:add]"}
{"concept_id": "C1819895", "aliases": [], "types": ["T046"], "canonical_name": "regulation of hypersensitivity", "definition": "Any process that modulates the frequency, rate, or extent of hypersensitivity. [GOC:add]"}
{"concept_id": "C1819896", "aliases": ["down-regulation of hypersensitivity", "down regulation of hypersensitivity", "downregulation of hypersensitivity"], "types": ["T040"], "canonical_name": "negative regulation of hypersensitivity", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity. [GOC:add]"}
{"concept_id": "C1819897", "aliases": ["upregulation of hypersensitivity", "up-regulation of hypersensitivity", "up regulation of hypersensitivity"], "types": ["T040"], "canonical_name": "positive regulation of hypersensitivity", "definition": "Any process that activates or increases the frequency, rate, or extent of hypersensitivity. [GOC:add]"}
{"concept_id": "C1819898", "aliases": [], "types": ["T038"], "canonical_name": "regulation of myeloid leukocyte mediated immunity", "definition": "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. [GOC:add]"}
{"concept_id": "C1819899", "aliases": ["downregulation of myeloid leukocyte mediated immunity", "down-regulation of myeloid leukocyte mediated immunity", "down regulation of myeloid leukocyte mediated immunity"], "types": ["T039"], "canonical_name": "negative regulation of myeloid leukocyte mediated immunity", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. [GOC:add]"}
{"concept_id": "C1819900", "aliases": ["upregulation of myeloid leukocyte mediated immunity", "up-regulation of myeloid leukocyte mediated immunity", "up regulation of myeloid leukocyte mediated immunity"], "types": ["T039"], "canonical_name": "positive regulation of myeloid leukocyte mediated immunity", "definition": "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. [GOC:add]"}
{"concept_id": "C1819901", "aliases": [], "types": ["T040"], "canonical_name": "regulation of immunoglobulin mediated immune response", "definition": "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response. [GOC:add]"}
{"concept_id": "C1819902", "aliases": ["downregulation of immunoglobulin mediated immune response", "down-regulation of immunoglobulin mediated immune response", "down regulation of immunoglobulin mediated immune response"], "types": ["T040"], "canonical_name": "negative regulation of immunoglobulin mediated immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response. [GOC:add]"}
{"concept_id": "C1819903", "aliases": ["upregulation of immunoglobulin mediated immune response", "up regulation of immunoglobulin mediated immune response", "up-regulation of immunoglobulin mediated immune response"], "types": ["T040"], "canonical_name": "positive regulation of immunoglobulin mediated immune response", "definition": "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. [GOC:add]"}
{"concept_id": "C1819904", "aliases": [], "types": ["T046"], "canonical_name": "regulation of type II hypersensitivity", "definition": "Any process that modulates the frequency, rate, or extent of type II hypersensitivity. [GOC:add]"}
{"concept_id": "C1819905", "aliases": ["down regulation of type II hypersensitivity", "down-regulation of type II hypersensitivity", "downregulation of type II hypersensitivity"], "types": ["T040"], "canonical_name": "negative regulation of type II hypersensitivity", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity. [GOC:add]"}
{"concept_id": "C1819906", "aliases": ["up-regulation of type II hypersensitivity", "upregulation of type II hypersensitivity", "up regulation of type II hypersensitivity"], "types": ["T040"], "canonical_name": "positive regulation of type II hypersensitivity", "definition": "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity. [GOC:add]"}
{"concept_id": "C1819907", "aliases": [], "types": ["T043"], "canonical_name": "regulation of central B cell tolerance induction", "definition": "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction. [GOC:add]"}
{"concept_id": "C1819908", "aliases": ["down regulation of central B cell tolerance induction", "down-regulation of central B cell tolerance induction", "downregulation of central B cell tolerance induction"], "types": ["T039"], "canonical_name": "negative regulation of central B cell tolerance induction", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction. [GOC:add]"}
{"concept_id": "C1819909", "aliases": ["upregulation of central B cell tolerance induction", "up-regulation of central B cell tolerance induction", "up regulation of central B cell tolerance induction"], "types": ["T039"], "canonical_name": "positive regulation of central B cell tolerance induction", "definition": "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction. [GOC:add]"}
{"concept_id": "C1819910", "aliases": [], "types": ["T043"], "canonical_name": "regulation of central B cell deletion", "definition": "Any process that modulates the frequency, rate, or extent of central B cell deletion. [GOC:add]"}
{"concept_id": "C1819911", "aliases": ["down regulation of central B cell deletion", "downregulation of central B cell deletion", "down-regulation of central B cell deletion"], "types": ["T043"], "canonical_name": "negative regulation of central B cell deletion", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion. [GOC:add]"}
{"concept_id": "C1819912", "aliases": ["up-regulation of central B cell deletion", "upregulation of central B cell deletion", "up regulation of central B cell deletion"], "types": ["T043"], "canonical_name": "positive regulation of central B cell deletion", "definition": "Any process that activates or increases the frequency, rate, or extent of central B cell deletion. [GOC:add]"}
{"concept_id": "C1819913", "aliases": ["programmed cell death of mature B cells by apoptosis", "programmed cell death of mature B-lymphocytes by apoptosis", "apoptosis of mature B lymphocytes", "programmed cell death of mature B-cells by apoptosis", "programmed cell death, mature B cells", "apoptosis of mature B-cells", "apoptosis of mature B-lymphocytes", "mature B cell apoptosis", "mature B cell programmed cell death by apoptosis", "mature B-cell programmed cell death by apoptosis", "mature B-cell apoptosis", "programmed cell death, mature B-lymphocytes", "mature B lymphocyte apoptosis", "mature B-lymphocyte apoptosis", "mature B lymphocyte programmed cell death by apoptosis", "programmed cell death, mature B-cells", "programmed cell death, mature B lymphocytes", "mature B-lymphocyte programmed cell death by apoptosis", "apoptosis of mature B cells", "programmed cell death of mature B lymphocytes by apoptosis"], "types": ["T043"], "canonical_name": "mature B cell apoptotic process", "definition": "Any apoptotic process in a B cell that is mature, having left the bone marrow. [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]"}
{"concept_id": "C1819914", "aliases": ["regulation of B cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of B cell apoptotic process", "definition": "Any process that modulates the frequency, rate, or extent of B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C1819916", "aliases": ["positive regulation of B cell apoptosis", "up-regulation of B cell apoptosis", "up regulation of B cell apoptosis", "upregulation of B cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of B cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C1819917", "aliases": ["regulation of mature B cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of mature B cell apoptotic process", "definition": "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C1819918", "aliases": ["down-regulation of mature B cell apoptosis", "downregulation of mature B cell apoptosis", "negative regulation of mature B cell apoptosis", "down regulation of mature B cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of mature B cell apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C1819919", "aliases": ["up-regulation of mature B cell apoptosis", "up regulation of mature B cell apoptosis", "positive regulation of mature B cell apoptosis", "upregulation of mature B cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of mature B cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C1819920", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peripheral B cell deletion", "definition": "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion. [GOC:add]"}
{"concept_id": "C1819921", "aliases": ["downregulation of peripheral B cell deletion", "down regulation of peripheral B cell deletion", "down-regulation of peripheral B cell deletion"], "types": ["T043"], "canonical_name": "negative regulation of peripheral B cell deletion", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion. [GOC:add]"}
{"concept_id": "C1819922", "aliases": [], "types": ["T042"], "canonical_name": "camera-type eye development", "definition": "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. [GOC:go_curators, GOC:mtg_sensu]"}
{"concept_id": "C1819923", "aliases": [], "types": ["T026"], "canonical_name": "cell soma cytoplasm"}
{"concept_id": "C1819924", "aliases": ["laminin-411 complex location", "laminin-411 complex", "laminin-8 complex location"], "types": ["T026"], "canonical_name": "laminin-8 complex", "definition": "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1819925", "aliases": ["laminin-421 complex location", "laminin-9 complex location", "laminin-421 complex"], "types": ["T026"], "canonical_name": "laminin-9 complex", "definition": "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1819926", "aliases": ["laminin-10 complex location", "laminin-511 complex", "laminin-511 complex location"], "types": ["T026"], "canonical_name": "laminin-10 complex", "definition": "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1819927", "aliases": ["laminin-521 complex location", "laminin-11 complex location", "laminin-521 complex"], "types": ["T026"], "canonical_name": "laminin-11 complex", "definition": "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1819928", "aliases": ["laminin-213 complex", "laminin-12 complex location", "laminin-213 complex location"], "types": ["T026"], "canonical_name": "laminin-12 complex", "definition": "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains. [GOC:jl, PMID:10842354]"}
{"concept_id": "C1819929", "aliases": ["CD4-positive, alpha beta T cell differentiation", "CD4-positive, alpha-beta T lymphocyte differentiation", "CD4-positive, alpha-beta T-lymphocyte differentiation", "CD4-positive, alpha-beta T-cell differentiation"], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta T cell differentiation", "definition": "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. [CL:0000624, ISBN:0781735149]"}
{"concept_id": "C1819930", "aliases": ["CD4-positive/CD8-positive, alpha-beta T cell lineage commitment", "CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment", "CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment", "CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment"], "types": ["T043"], "canonical_name": "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment", "definition": "The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. [ISBN:0781735149]"}
{"concept_id": "C1819931", "aliases": ["CD4-positive, alpha-beta T-lymphocyte lineage commitment", "CD4-positive, alpha-beta T-cell lineage commitment", "CD4-positive, alpha-beta T lymphocyte lineage commitment"], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta T cell lineage commitment", "definition": "The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell. [ISBN:0781735149]"}
{"concept_id": "C1819932", "aliases": ["CD8-positive, alpha-beta T-lymphocyte differentiation", "CD8-positive, alpha-beta T-cell differentiation", "CD8-positive, alpha-beta T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta T cell differentiation", "definition": "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell. [ISBN:0781735149]"}
{"concept_id": "C1819933", "aliases": ["CD8-positive, alpha-beta T lymphocyte lineage commitment", "CD8-positive, alpha-beta T-cell lineage commitment", "CD8-positive, alpha-beta T-lymphocyte lineage commitment", "CD8-positive, alpha-beta T cell fate commitment"], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta T cell lineage commitment", "definition": "The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell. [ISBN:0781735149]"}
{"concept_id": "C1819934", "aliases": [], "types": ["T044"], "canonical_name": "anthranilic acid metabolic process"}
{"concept_id": "C1819935", "aliases": [], "types": ["T044"], "canonical_name": "ortho-aminobenzoic acid metabolic process"}
{"concept_id": "C1819936", "aliases": [], "types": ["T044"], "canonical_name": "anthranilic acid catabolic process"}
{"concept_id": "C1819937", "aliases": [], "types": ["T044"], "canonical_name": "ortho-aminobenzoic acid catabolic process"}
{"concept_id": "C1819938", "aliases": [], "types": ["T044"], "canonical_name": "regulation of fucose catabolic process", "definition": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose. [GOC:mlg]"}
{"concept_id": "C1819939", "aliases": [], "types": ["T044"], "canonical_name": "regulation of D-xylose catabolic process", "definition": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose. [GOC:mlg]"}
{"concept_id": "C1819940", "aliases": [], "types": ["T043"], "canonical_name": "regulation of carbohydrate catabolic process", "definition": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. [GOC:mlg]"}
{"concept_id": "C1819941", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cellular carbohydrate catabolic process", "definition": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. [GOC:jl]"}
{"concept_id": "C1819942", "aliases": [], "types": ["T043"], "canonical_name": "pigment biosynthetic process during pigment accumulation"}
{"concept_id": "C1819943", "aliases": ["anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus", "anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light"], "types": ["T044"], "canonical_name": "anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus"}
{"concept_id": "C1819944", "aliases": [], "types": ["T043"], "canonical_name": "neuron survival"}
{"concept_id": "C1819945", "aliases": [], "types": ["T045"], "canonical_name": "CRISPR element metabolic process"}
{"concept_id": "C1819946", "aliases": [], "types": ["T044"], "canonical_name": "amide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [GOC:curators]"}
{"concept_id": "C1819947", "aliases": [], "types": ["T044"], "canonical_name": "cellular amide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [GOC:curators]"}
{"concept_id": "C1819948", "aliases": [], "types": ["T044"], "canonical_name": "formamide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid. [GOC:jl]"}
{"concept_id": "C1819949", "aliases": [], "types": ["T044"], "canonical_name": "formamide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid. [GOC:jl]"}
{"concept_id": "C1819950", "aliases": ["multifactor translation initiation factor (eIF) complex location", "multi-eIF complex location", "multifactor translation initiation factor (eIF) complex"], "types": ["T026"], "canonical_name": "multi-eIF complex", "definition": "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5. [GOC:krc]"}
{"concept_id": "C1819951", "aliases": ["astrocyte migration", "astrocytic glial cell migration"], "types": ["T043"], "canonical_name": "astrocyte cell migration", "definition": "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord. [CL:0000127, GOC:go_curators]"}
{"concept_id": "C1819952", "aliases": [], "types": ["T043"], "canonical_name": "keratinocyte proliferation", "definition": "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. [CL:0000311]"}
{"concept_id": "C1819953", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to sucrose starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose. [GOC:jl]"}
{"concept_id": "C1819954", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter in response to stress", "definition": "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:jl]"}
{"concept_id": "C1819955", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter in response to oxidative stress", "definition": "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl]"}
{"concept_id": "C1819956", "aliases": ["regulation of DNA-dependent transcription in response to stress"], "types": ["T045"], "canonical_name": "regulation of DNA-templated transcription in response to stress", "definition": "Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:jl, GOC:txnOH]"}
{"concept_id": "C1819957", "aliases": ["intramolecular protein binding", "protein self binding", "protein self association"], "types": ["T044"], "canonical_name": "protein self-association", "definition": "Binding to a domain within the same polypeptide. [GOC:jl]"}
{"concept_id": "C1819958", "aliases": ["cortical microtubule organization and biogenesis", "cortical microtubule organisation", "cortical microtubule cytoskeleton organization"], "types": ["T043"], "canonical_name": "cortical microtubule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell. [GOC:curators, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C1819961", "aliases": ["proliferating cell nuclear antigen complex", "PCNA homotrimer", "proliferating cell nuclear antigen complex location", "PCNA complex location"], "types": ["T026"], "canonical_name": "PCNA complex", "definition": "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. [GOC:jl, PMID:12829735]"}
{"concept_id": "C1819962", "aliases": ["response to oestrogen stimulus", "response to estrogen stimulus"], "types": ["T043"], "canonical_name": "response to estrogen", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C1819963", "aliases": ["ncRNA 3' end processing", "ncRNA 3'-end processing"], "types": ["T045"], "canonical_name": "small regulatory ncRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of small regulatory non-coding RNA molecule. [GOC:jl]"}
{"concept_id": "C1819964", "aliases": ["non-coding RNA polyadenylation"], "types": ["T044"], "canonical_name": "ncRNA polyadenylation", "definition": "The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation. [GOC:dgf, GOC:krc, GOC:rn, PMID:15828860, PMID:15935758, PMID:16374505, PMID:16431988, PMID:18951092]"}
{"concept_id": "C1819965", "aliases": [], "types": ["T045"], "canonical_name": "ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process"}
{"concept_id": "C1819966", "aliases": [], "types": ["T043"], "canonical_name": "modification-dependent macromolecule catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule. [GOC:jl]"}
{"concept_id": "C1819968", "aliases": [], "types": ["T045"], "canonical_name": "polyadenylation-dependent ncRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA. [GOC:dgf, GOC:jl, GOC:krc]"}
{"concept_id": "C1819969", "aliases": [], "types": ["T043"], "canonical_name": "methylnaphthalene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar. [GOC:jl, PMID:16535687]"}
{"concept_id": "C1819970", "aliases": ["1-methylnaphthalene catabolism"], "types": ["T043"], "canonical_name": "1-methylnaphthalene catabolic process"}
{"concept_id": "C1819971", "aliases": ["1-MN catabolism"], "types": ["T043"], "canonical_name": "1-MN catabolic process"}
{"concept_id": "C1819972", "aliases": ["2-methylnaphthalene catabolism"], "types": ["T043"], "canonical_name": "2-methylnaphthalene catabolic process"}
{"concept_id": "C1819973", "aliases": ["2-MN catabolism"], "types": ["T043"], "canonical_name": "2-MN catabolic process"}
{"concept_id": "C1819974", "aliases": ["bisphenol-A catabolism", "bisphenol-A catabolic process"], "types": ["T044"], "canonical_name": "bisphenol A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins. [GOC:jl, Wikipedia:Bisphenol_A]"}
{"concept_id": "C1819975", "aliases": ["puromycin metabolism"], "types": ["T044"], "canonical_name": "puromycin metabolic process", "definition": "The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger. [GOC:jl, PMID:8226694, Wikipedia:Puromycin]"}
{"concept_id": "C1819976", "aliases": [], "types": ["T044"], "canonical_name": "puromycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger. [GOC:jl, Wikipedia:Puromycin]"}
{"concept_id": "C1819977", "aliases": ["benzoate breakdown", "benzoate degradation", "benzoate catabolism"], "types": ["T044"], "canonical_name": "benzoate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. [GOC:jl]"}
{"concept_id": "C1819978", "aliases": ["benzoate degradation via hydroxylation", "benzoate breakdown via hydroxylation"], "types": ["T044"], "canonical_name": "benzoate catabolic process via hydroxylation", "definition": "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol. [GOC:jl, MetaCyc:PWY-2503]"}
{"concept_id": "C1819979", "aliases": ["novobiocin metabolism"], "types": ["T044"], "canonical_name": "novobiocin metabolic process", "definition": "The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase. [GOC:jl]"}
{"concept_id": "C1819980", "aliases": [], "types": ["T044"], "canonical_name": "novobiocin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase. [GOC:jl]"}
{"concept_id": "C1819981", "aliases": ["tetracyclin metabolic process", "tetracyclin metabolism", "tetracycline metabolism"], "types": ["T044"], "canonical_name": "tetracycline metabolic process", "definition": "The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). [GOC:jl, Wikipedia:Tetracycline]"}
{"concept_id": "C1819982", "aliases": ["tetracyclin biosynthetic process", "tetracyclin biosynthesis"], "types": ["T044"], "canonical_name": "tetracycline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). [GOC:jl, Wikipedia:Tetracycline]"}
{"concept_id": "C1819983", "aliases": ["cephalosporin metabolism"], "types": ["T044"], "canonical_name": "cephalosporin metabolic process", "definition": "The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria. [GOC:jl, Wikipedia:Cephalosporin]"}
{"concept_id": "C1819984", "aliases": [], "types": ["T044"], "canonical_name": "cephalosporin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria. [GOC:jl, Wikipedia:Cephalosporin]"}
{"concept_id": "C1819985", "aliases": ["myo-inositol phosphate metabolism"], "types": ["T044"], "canonical_name": "myo-inositol phosphate metabolic process"}
{"concept_id": "C1819986", "aliases": ["dicarboxylate metabolic process", "dicarboxylate metabolism", "dicarboxylic acid metabolism"], "types": ["T044"], "canonical_name": "dicarboxylic acid metabolic process", "definition": "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). [ISBN:0198506732]"}
{"concept_id": "C1819987", "aliases": ["dicarboxylate catabolism", "dicarboxylic acid degradation", "dicarboxylic acid breakdown", "dicarboxylate catabolic process", "dicarboxylic acid catabolism"], "types": ["T044"], "canonical_name": "dicarboxylic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. [ISBN:0198506732]"}
{"concept_id": "C1819988", "aliases": ["dicarboxylic acid synthesis", "dicarboxylic acid anabolism", "dicarboxylate biosynthetic process", "dicarboxylate biosynthesis", "dicarboxylic acid biosynthesis", "dicarboxylic acid formation"], "types": ["T044"], "canonical_name": "dicarboxylic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. [ISBN:0198506732]"}
{"concept_id": "C1819989", "aliases": ["linoleic acid metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. [Wikipedia:Linoleic_Acid]", "canonical_name": "linoleic acid metabolic process"}
{"concept_id": "C1819990", "aliases": ["engulfment of cell corpse", "engulfment of apoptotic cell corpse"], "types": ["T043"], "canonical_name": "engulfment of apoptotic cell", "definition": "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte. [GOC:rk, PMID:15536015]"}
{"concept_id": "C1819991", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial fission during apoptosis"}
{"concept_id": "C1819992", "aliases": ["detection of apoptotic cell", "detection of cell corpse", "recognition of cell corpse", "detection of apoptotic cell corpse", "recognition of apoptotic cell corpse"], "types": ["T043"], "canonical_name": "recognition of apoptotic cell", "definition": "The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis. [GOC:rk, PMID:15536015]"}
{"concept_id": "C1819993", "aliases": ["extracellular space of host"], "types": ["T026"], "canonical_name": "host extracellular space", "definition": "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream. [GOC:cc]"}
{"concept_id": "C1819994", "aliases": ["intracellular region of host", "host intracellular"], "types": ["T026"], "canonical_name": "host intracellular region", "definition": "That space within the plasma membrane of a host cell. [GOC:cc]"}
{"concept_id": "C1819995", "aliases": [], "types": ["T026"], "definition": "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope. [GOC:jl]", "canonical_name": "host cell"}
{"concept_id": "C1819996", "aliases": [], "types": ["T026"], "canonical_name": "host symbiosome", "definition": "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell. [GOC:cc]"}
{"concept_id": "C1819997", "aliases": [], "types": ["T026"], "canonical_name": "symbiosome", "definition": "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane). [GOC:cc]"}
{"concept_id": "C1819998", "aliases": [], "types": ["T026"], "canonical_name": "bacteroid-containing symbiosome", "definition": "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants. [GOC:cc]"}
{"concept_id": "C1819999", "aliases": [], "types": ["T026"], "canonical_name": "peribacteroid membrane", "definition": "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells). [GOC:cc]"}
{"concept_id": "C1820000", "aliases": [], "types": ["T026"], "canonical_name": "peribacteroid fluid", "definition": "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome. [GOC:cc]"}
{"concept_id": "C1820001", "aliases": [], "types": ["T026"], "canonical_name": "host bacteroid-containing symbiosome", "definition": "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell. [GOC:cc]"}
{"concept_id": "C1820002", "aliases": [], "types": ["T026"], "canonical_name": "host peribacteroid membrane", "definition": "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells). [GOC:cc]"}
{"concept_id": "C1820003", "aliases": [], "types": ["T026"], "canonical_name": "host peribacteroid fluid", "definition": "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell. [GOC:cc]"}
{"concept_id": "C1820004", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphoprotein phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. [GOC:jp, PMID:11724821]"}
{"concept_id": "C1820005", "aliases": ["microspore wall"], "types": ["T026"], "canonical_name": "pollen wall", "definition": "The wall surrounding a mature pollen grain; a multilayered structure consisting of a pectocellulosic intine surrounded by a sporopollenin-based exine, which itself contains two layers, the inner nexine and the outer sexine. [GOC:fz, PMID:15131249]"}
{"concept_id": "C1820006", "aliases": [], "types": ["T026"], "canonical_name": "exine", "definition": "The outer layer of the pollen grain wall which is composed primarily of sporopollenin. [http://www.mobot.org/MOBOT/research/APweb/]"}
{"concept_id": "C1820007", "aliases": [], "types": ["T026"], "canonical_name": "ectexine", "definition": "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections. [http://www.mobot.org/MOBOT/research/APweb/]"}
{"concept_id": "C1820008", "aliases": ["nexine 1"], "types": ["T026"], "canonical_name": "foot layer", "definition": "The inner layer of the ectexine. [http://www.mobot.org/MOBOT/research/APweb/]"}
{"concept_id": "C1820009", "aliases": [], "types": ["T026"], "canonical_name": "endexine", "definition": "The inner part of the exine, which stains. [http://www.mobot.org/MOBOT/research/APweb/]"}
{"concept_id": "C1820010", "aliases": [], "types": ["T026"], "canonical_name": "nexine", "definition": "The inner, non-sculptured part of the exine which lies below the sexine. [http://www.mobot.org/MOBOT/research/APweb/]"}
{"concept_id": "C1820011", "aliases": [], "types": ["T026"], "canonical_name": "sexine", "definition": "The outer, sculptured layer of the exine, which lies above the nexine. [http://www.mobot.org/MOBOT/research/APweb/]"}
{"concept_id": "C1820012", "aliases": [], "types": ["T026"], "canonical_name": "sculpture element", "definition": "The third layer of the sexine. [http://www.mobot.org/MOBOT/research/APweb/]"}
{"concept_id": "C1820014", "aliases": [], "types": ["T026"], "canonical_name": "intine", "definition": "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm. [http://www.mobot.org/MOBOT/research/APweb/]"}
{"concept_id": "C1820015", "aliases": [], "types": ["T026"], "canonical_name": "filiform apparatus", "definition": "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells. [ISBN:0471245208]"}
{"concept_id": "C1820017", "aliases": ["copper exporting ATPase activity", "copper-transporting ATPase activity", "Cu2+-exporting ATPase activity", "Cu(2+)-exporting ATPase activity"], "types": ["T044"], "canonical_name": "copper transmembrane transporter activity, phosphorylative mechanism"}
{"concept_id": "C1820018", "aliases": ["type IV fimbria biogenesis", "type IV fimbriae biogenesis", "type IV fimbrium assembly", "type IV fimbria assembly", "type IV fimbrial biogenesis", "type IV fimbrial assembly", "type IV pilus biogenesis", "type IV fimbriae assembly", "type IV fimbrium biogenesis"], "types": ["T043"], "canonical_name": "type IV pilus assembly", "definition": "The assembly from its constituent parts of a type IV pilus. [GOC:jl, GOC:ml, PMID:31784891]"}
{"concept_id": "C1820019", "aliases": ["type IV protein secretion system complex location", "T4SS complex location", "T4SS complex", "type IV secretion system complex location", "type IV protein secretion system complex"], "types": ["T026"], "canonical_name": "type IV secretion system complex", "definition": "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s). [GOC:ml]"}
{"concept_id": "C1820020", "aliases": [], "types": ["T040"], "canonical_name": "disruption by symbiont of host cell"}
{"concept_id": "C1820025", "aliases": [], "types": ["T044"], "canonical_name": "sulfur biosynthetic process"}
{"concept_id": "C1820026", "aliases": [], "types": ["T044"], "canonical_name": "sulfur catabolic process"}
{"concept_id": "C1820029", "aliases": [], "types": ["T040"], "canonical_name": "evasion or tolerance of host defenses"}
{"concept_id": "C1820030", "aliases": ["activation of host defense response", "activation by symbiont of host defense response"], "types": ["T040"], "canonical_name": "induction by symbiont of host defense response", "definition": "The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C1820032", "aliases": ["virion part"], "types": ["T026"], "canonical_name": "virion component", "definition": "Any constituent part of a virion, a complete fully infectious extracellular virus particle. [GOC:jl]"}
{"concept_id": "C1820050", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasm component", "definition": "OBSOLETE. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [GOC:jl]"}
{"concept_id": "C1820070", "aliases": [], "types": ["T044"], "canonical_name": "HDEL sequence binding", "definition": "Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. [PMID:1327759]"}
{"concept_id": "C1820073", "aliases": [], "types": ["T043"], "canonical_name": "bouquet biosynthesis"}
{"concept_id": "C1820074", "aliases": ["myosin I complex location"], "types": ["T026"], "canonical_name": "myosin I complex", "definition": "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839]"}
{"concept_id": "C1820076", "aliases": ["tubulin complex location"], "types": ["T026"], "canonical_name": "tubulin complex", "definition": "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly. [ISBN:0716731363]"}
{"concept_id": "C1820077", "aliases": [], "types": ["T079"], "canonical_name": "circadian locomotor activity rhythm"}
{"concept_id": "C1820078", "aliases": ["germ plasm"], "types": ["T026"], "canonical_name": "germ plasm", "definition": "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line. [GOC:dph]"}
{"concept_id": "C1820079", "aliases": [], "types": ["T042"], "canonical_name": "male analia development", "definition": "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11494318]"}
{"concept_id": "C1820080", "aliases": [], "types": ["T042"], "canonical_name": "female analia development", "definition": "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11494318]"}
{"concept_id": "C1820083", "aliases": ["siderophore breakdown", "siderophore catabolism", "siderophore degradation"], "types": ["T044"], "canonical_name": "siderophore catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. [GOC:ai]"}
{"concept_id": "C1820091", "aliases": ["spliceosomal commitment complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal commitment complex biosynthesis"}
{"concept_id": "C1820094", "aliases": [], "types": ["T045"], "canonical_name": "lariat RNA biosynthesis"}
{"concept_id": "C1820098", "aliases": ["Holliday junction binding"], "types": ["T045"], "canonical_name": "four-way junction DNA binding", "definition": "Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. [GOC:krc, ISBN:0815332181, PMID:15563464]"}
{"concept_id": "C1820099", "aliases": ["open form Holliday junction binding"], "types": ["T045"], "canonical_name": "open form four-way junction DNA binding", "definition": "Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over. [GOC:krc, ISBN:0815332181, PMID:15563464]"}
{"concept_id": "C1820100", "aliases": ["crossed form Holliday junction binding"], "types": ["T045"], "canonical_name": "crossed form four-way junction DNA binding", "definition": "Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands. [GOC:krc, ISBN:0815332181, PMID:15563464]"}
{"concept_id": "C1820101", "aliases": ["splayed Y-form DNA binding"], "types": ["T045"], "canonical_name": "Y-form DNA binding", "definition": "Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. [GOC:elh, PMID:16781730]"}
{"concept_id": "C1820102", "aliases": ["loop DNA binding"], "types": ["T045"], "canonical_name": "heteroduplex DNA loop binding", "definition": "Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. [GOC:elh, PMID:16781730]"}
{"concept_id": "C1820103", "aliases": [], "types": ["T045"], "canonical_name": "bubble DNA binding", "definition": "Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. [GOC:elh, GOC:vw, PMID:16781730]"}
{"concept_id": "C1820104", "aliases": [], "types": ["T045"], "canonical_name": "double-strand/single-strand DNA junction binding", "definition": "Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA. [GOC:elh, PMID:16781730]"}
{"concept_id": "C1820105", "aliases": ["endopeptidase-like kinase chromatin-associated protein complex", "endopeptidase-like kinase chromatin-associated protein complex location", "kinase, putative endopeptidase and other proteins of small size protein complex location", "EKC/KEOPS complex location", "kinase, putative endopeptidase and other proteins of small size protein complex", "KEOPS/EKC complex", "KEOPS/EKC complex location"], "types": ["T026"], "canonical_name": "EKC/KEOPS complex", "definition": "A protein complex involved in t6A tRNA modification. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p. [GOC:elh, GOC:vw, PMID:16564010, PMID:16874308, PMID:21183954, PMID:23945934]"}
{"concept_id": "C1820106", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription by galactose", "definition": "Any process involving galactose that modulates the frequency, rate or extent or transcription. [GOC:go_curators]"}
{"concept_id": "C1820107", "aliases": ["downregulation of transcription by galactose", "down regulation of transcription by galactose", "down-regulation of transcription by galactose"], "types": ["T045"], "canonical_name": "carbon catabolite repression of transcription by galactose", "definition": "A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. [GOC:mah]"}
{"concept_id": "C1820108", "aliases": ["up regulation of transcription by galactose", "up-regulation of transcription by galactose", "upregulation of transcription by galactose"], "types": ["T045"], "canonical_name": "positive regulation of transcription by galactose", "definition": "Any process involving galactose that activates or increases the rate of transcription. [GOC:go_curators]"}
{"concept_id": "C1820109", "aliases": ["histone proline isomerization"], "types": ["T044"], "canonical_name": "histone peptidyl-prolyl isomerization", "definition": "The modification of a histone by cis-trans isomerization of a proline residue. [GOC:krc]"}
{"concept_id": "C1820110", "aliases": ["protein proline isomerization"], "types": ["T044"], "canonical_name": "protein peptidyl-prolyl isomerization", "definition": "The modification of a protein by cis-trans isomerization of a proline residue. [GOC:krc, PMID:16959570]"}
{"concept_id": "C1820111", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H3-K36 methylation", "definition": "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. [GOC:krc]"}
{"concept_id": "C1820112", "aliases": ["downregulation of histone H3-K36 methylation", "down regulation of histone H3-K36 methylation", "down-regulation of histone H3-K36 methylation"], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K36 methylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. [GOC:krc]"}
{"concept_id": "C1820113", "aliases": ["upregulation of histone H3-K36 methylation", "up regulation of histone H3-K36 methylation", "up-regulation of histone H3-K36 methylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K36 methylation", "definition": "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. [GOC:krc]"}
{"concept_id": "C1820114", "aliases": ["HIRA complex location", "HIR complex location", "HIRA complex"], "types": ["T026"], "canonical_name": "HIR complex", "definition": "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p. [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700]"}
{"concept_id": "C1820115", "aliases": ["DNA-directed RNA polymerase IVa complex location", "DNA-directed RNA polymerase IVa complex", "DNA-directed RNA polymerase IV complex location", "DNA-directed RNA polymerase IV complex", "RNA polymerase IV complex location"], "types": ["T026"], "canonical_name": "RNA polymerase IV complex", "definition": "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex. [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459]"}
{"concept_id": "C1820118", "aliases": ["autophagic vacuole membrane"], "types": ["T026"], "canonical_name": "autophagosome membrane", "definition": "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. [GOC:autophagy, GOC:isa_complete]"}
{"concept_id": "C1820119", "aliases": ["macromitophagy", "autophagy of mitochondrion", "mitochondrion autophagy"], "types": ["T043"], "definition": "The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]", "canonical_name": "mitophagy"}
{"concept_id": "C1820121", "aliases": [], "types": ["T043"], "canonical_name": "micromitophagy", "definition": "Degradation of a mitochondrion by lysosomal microautophagy. [PMID:15798367, PMID:27003723]"}
{"concept_id": "C1820123", "aliases": [], "types": ["T043"], "definition": "Degradation of a peroxisome by lysosomal microautophagy. [GOC:autophagy, GOC:pad, PMID:12914914, PMID:15350980, PMID:16973210]", "canonical_name": "micropexophagy"}
{"concept_id": "C1820124", "aliases": ["plastid-encoded plastid RNA polymerase complex location"], "types": ["T026"], "canonical_name": "plastid-encoded plastid RNA polymerase complex", "definition": "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition. [GOC:krc, GOC:mah, GOC:pj]"}
{"concept_id": "C1820125", "aliases": ["DNA-directed RNA polymerase complex location"], "types": ["T026"], "canonical_name": "DNA-directed RNA polymerase complex", "definition": "A protein complex that possesses DNA-directed RNA polymerase activity. [GOC:krc]"}
{"concept_id": "C1820126", "aliases": ["regulation of transcription from RNA polymerase II promoter by carbon catabolites"], "types": ["T045"], "canonical_name": "carbon catabolite regulation of transcription from RNA polymerase II promoter", "definition": "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. [GOC:krc, GOC:mah]"}
{"concept_id": "C1820127", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter by glucose", "definition": "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:krc]"}
{"concept_id": "C1820128", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter by galactose", "definition": "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:krc]"}
{"concept_id": "C1820129", "aliases": ["upregulation of transcription from RNA polymerase II promoter by glucose", "up-regulation of transcription from RNA polymerase II promoter by glucose", "up regulation of transcription from RNA polymerase II promoter by glucose"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter by glucose", "definition": "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter. [GOC:krc]"}
{"concept_id": "C1820130", "aliases": ["down-regulation of transcription from RNA polymerase II promoter by glucose", "down regulation of transcription from RNA polymerase II promoter by glucose", "downregulation of transcription from RNA polymerase II promoter by glucose"], "types": ["T045"], "canonical_name": "carbon catabolite repression of transcription from RNA polymerase II promoter by glucose", "definition": "A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. [GOC:krc]"}
{"concept_id": "C1820131", "aliases": ["down-regulation of transcription from RNA polymerase II promoter by galactose", "downregulation of transcription from RNA polymerase II promoter by galactose", "down regulation of transcription from RNA polymerase II promoter by galactose"], "types": ["T045"], "canonical_name": "carbon catabolite repression of transcription from RNA polymerase II promoter by galactose", "definition": "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. [GOC:krc]"}
{"concept_id": "C1820132", "aliases": ["up regulation of transcription from RNA polymerase II promoter by galactose", "upregulation of transcription from RNA polymerase II promoter by galactose", "up-regulation of transcription from RNA polymerase II promoter by galactose"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter by galactose", "definition": "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter. [GOC:krc]"}
{"concept_id": "C1820133", "aliases": ["positive regulation of transcription from RNA polymerase II promoter by carbon catabolites"], "types": ["T045"], "canonical_name": "carbon catabolite activation of transcription from RNA polymerase II promoter", "definition": "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:krc]"}
{"concept_id": "C1820135", "aliases": [], "types": ["T043"], "canonical_name": "flocculation via cell wall protein-carbohydrate interaction"}
{"concept_id": "C1820138", "aliases": ["oxidized pyrimidine base lesion DNA N-glycosylase activity"], "types": ["T045"], "canonical_name": "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity", "definition": "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. [GOC:elh, PMID:11554296]"}
{"concept_id": "C1820139", "aliases": [], "types": ["T045"], "canonical_name": "meiotic D-loop biosynthesis"}
{"concept_id": "C1820140", "aliases": ["upregulation of peripheral B cell deletion", "up-regulation of peripheral B cell deletion", "up regulation of peripheral B cell deletion"], "types": ["T043"], "canonical_name": "positive regulation of peripheral B cell deletion", "definition": "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion. [GOC:add]"}
{"concept_id": "C1820141", "aliases": [], "types": ["T038"], "canonical_name": "regulation of lymphocyte anergy", "definition": "Any process that modulates the frequency, rate, or extent of lymphocyte anergy. [GOC:add]"}
{"concept_id": "C1820142", "aliases": ["down-regulation of lymphocyte anergy", "downregulation of lymphocyte anergy", "down regulation of lymphocyte anergy"], "types": ["T043"], "canonical_name": "negative regulation of lymphocyte anergy", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy. [GOC:add]"}
{"concept_id": "C1820143", "aliases": ["upregulation of lymphocyte anergy", "up-regulation of lymphocyte anergy", "up regulation of lymphocyte anergy"], "types": ["T043"], "canonical_name": "positive regulation of lymphocyte anergy", "definition": "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy. [GOC:add]"}
{"concept_id": "C1820144", "aliases": [], "types": ["T043"], "canonical_name": "regulation of central B cell anergy", "definition": "Any process that modulates the frequency, rate, or extent of central B cell anergy. [GOC:add]"}
{"concept_id": "C1820145", "aliases": ["downregulation of central B cell anergy", "down regulation of central B cell anergy", "down-regulation of central B cell anergy"], "types": ["T043"], "canonical_name": "negative regulation of central B cell anergy", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy. [GOC:add]"}
{"concept_id": "C1820146", "aliases": ["upregulation of central B cell anergy", "up-regulation of central B cell anergy", "up regulation of central B cell anergy"], "types": ["T043"], "canonical_name": "positive regulation of central B cell anergy", "definition": "Any process that activates or increases the frequency, rate, or extent of central B cell anergy. [GOC:add]"}
{"concept_id": "C1820147", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peripheral B cell anergy", "definition": "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy. [GOC:add]"}
{"concept_id": "C1820148", "aliases": ["downregulation of peripheral B cell anergy", "down-regulation of peripheral B cell anergy", "down regulation of peripheral B cell anergy"], "types": ["T043"], "canonical_name": "negative regulation of peripheral B cell anergy", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy. [GOC:add]"}
{"concept_id": "C1820149", "aliases": ["upregulation of peripheral B cell anergy", "up-regulation of peripheral B cell anergy", "up regulation of peripheral B cell anergy"], "types": ["T043"], "canonical_name": "positive regulation of peripheral B cell anergy", "definition": "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy. [GOC:add]"}
{"concept_id": "C1820150", "aliases": [], "types": ["T040"], "canonical_name": "regulation of humoral immune response", "definition": "Any process that modulates the frequency, rate, or extent of a humoral immune response. [GOC:add]"}
{"concept_id": "C1820151", "aliases": ["down regulation of humoral immune response", "down-regulation of humoral immune response", "downregulation of humoral immune response"], "types": ["T040"], "canonical_name": "negative regulation of humoral immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. [GOC:add]"}
{"concept_id": "C1820152", "aliases": ["up-regulation of humoral immune response", "upregulation of humoral immune response", "up regulation of humoral immune response"], "types": ["T040"], "canonical_name": "positive regulation of humoral immune response", "definition": "Any process that activates or increases the frequency, rate, or extent of a humoral immune response. [GOC:add]"}
{"concept_id": "C1820153", "aliases": [], "types": ["T040"], "canonical_name": "regulation of humoral immune response mediated by circulating immunoglobulin", "definition": "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. [GOC:add]"}
{"concept_id": "C1820154", "aliases": ["down regulation of humoral immune response mediated by circulating immunoglobulin", "down-regulation of humoral immune response mediated by circulating immunoglobulin", "downregulation of humoral immune response mediated by circulating immunoglobulin"], "types": ["T040"], "canonical_name": "negative regulation of humoral immune response mediated by circulating immunoglobulin", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. [GOC:add]"}
{"concept_id": "C1820155", "aliases": ["up-regulation of humoral immune response mediated by circulating immunoglobulin", "up regulation of humoral immune response mediated by circulating immunoglobulin", "upregulation of humoral immune response mediated by circulating immunoglobulin"], "types": ["T040"], "canonical_name": "positive regulation of humoral immune response mediated by circulating immunoglobulin", "definition": "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. [GOC:add]"}
{"concept_id": "C1820158", "aliases": [], "types": ["T042"], "canonical_name": "regionalization", "definition": "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. [GOC:dph, GOC:isa_complete]"}
{"concept_id": "C1820159", "aliases": [], "types": ["T040"], "canonical_name": "follicular fluid formation in ovarian follicle antrum during fused antrum stage"}
{"concept_id": "C1820160", "aliases": [], "types": ["T040"], "canonical_name": "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage"}
{"concept_id": "C1820161", "aliases": [], "types": ["T040"], "canonical_name": "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage"}
{"concept_id": "C1820162", "aliases": ["reproductive developmental process"], "types": ["T039"], "canonical_name": "developmental process involved in reproduction", "definition": "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. [GOC:dph, GOC:isa_complete]"}
{"concept_id": "C1820163", "aliases": ["cardiac morphogenesis"], "types": ["T042"], "canonical_name": "heart morphogenesis", "definition": "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:dph, GOC:isa_complete]"}
{"concept_id": "C1820164", "aliases": [], "types": ["T044"], "canonical_name": "terpene synthase activity", "definition": "Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units. [EC:4.2.3.-, GOC:tair_curators]"}
{"concept_id": "C1820165", "aliases": ["lysosomal hydrogen ion-transporting ATPase V0 domain"], "types": ["T026"], "canonical_name": "lysosomal proton-transporting V-type ATPase, V0 domain", "definition": "The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. [GOC:mah]"}
{"concept_id": "C1820166", "aliases": ["lysosomal hydrogen ion-transporting ATPase V1 domain"], "types": ["T026"], "canonical_name": "lysosomal proton-transporting V-type ATPase, V1 domain", "definition": "The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. [GOC:mah]"}
{"concept_id": "C1820167", "aliases": [], "types": ["T044"], "canonical_name": "efflux-type boron transporter"}
{"concept_id": "C1820169", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen ion translocating A-type ATPase activity"}
{"concept_id": "C1820171", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen ion translocating V-type ATPase activity"}
{"concept_id": "C1820173", "aliases": ["exogenous lipid antigen processing and presentation via MHC class Ib", "antigen presentation, exogenous peptide antigen"], "types": ["T043"], "canonical_name": "antigen processing and presentation, exogenous lipid antigen via MHC class Ib", "definition": "The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]"}
{"concept_id": "C1820176", "aliases": [], "types": ["T040"], "canonical_name": "timing of organ biosynthesis"}
{"concept_id": "C1820177", "aliases": ["spermatid cell differentiation"], "types": ["T043"], "canonical_name": "spermatid differentiation", "definition": "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dph, GOC:jid]"}
{"concept_id": "C1820178", "aliases": ["camera-style eye morphogenesis"], "types": ["T042"], "canonical_name": "camera-type eye morphogenesis", "definition": "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C1820179", "aliases": ["reproductive process in a multicellular organism", "organismal reproductive process"], "types": ["T043"], "canonical_name": "multicellular organismal reproductive process", "definition": "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. [GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C1820182", "aliases": [], "types": ["T042"], "canonical_name": "axon extension involved in regeneration", "definition": "Long distance growth of a single axon process involved in regeneration of the neuron. [GOC:jid]"}
{"concept_id": "C1820183", "aliases": [], "types": ["T038"], "canonical_name": "regulation of axon extension involved in regeneration", "definition": "Any process that modulates the frequency, rate or extent of axon extension involved in regeneration. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1820184", "aliases": ["up-regulation of axon extension involved in regeneration", "up regulation of axon extension involved in regeneration", "upregulation of axon extension involved in regeneration"], "types": ["T039"], "canonical_name": "positive regulation of axon extension involved in regeneration", "definition": "Any process that activates, maintains or increases the rate of axon extension involved in regeneration. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1820185", "aliases": ["down-regulation of axon extension involved in regeneration", "downregulation of axon extension involved in regeneration", "down regulation of axon extension involved in regeneration"], "types": ["T039"], "canonical_name": "negative regulation of axon extension involved in regeneration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C1820186", "aliases": ["neuron generation"], "types": ["T040"], "canonical_name": "generation of neurons", "definition": "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. [GOC:nln]"}
{"concept_id": "C1820187", "aliases": [], "types": ["T042"], "canonical_name": "pigment granule maturation", "definition": "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state. [GOC:dgh, GOC:jid, GOC:mh]"}
{"concept_id": "C1820188", "aliases": [], "types": ["T043"], "canonical_name": "companion cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member. [CL:0000284, GOC:jid]"}
{"concept_id": "C1820189", "aliases": ["vessel element cell differentiation"], "types": ["T043"], "canonical_name": "vessel member cell differentiation"}
{"concept_id": "C1820190", "aliases": ["parenchymal cell differentiation"], "types": ["T043"], "canonical_name": "plant parenchymal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure. [CL:0000668, GOC:jid, ISBN:069716957X, PO:0005421]"}
{"concept_id": "C1820191", "aliases": [], "types": ["T043"], "canonical_name": "collenchyma cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles. [CL:0000330, GOC:jid, PO:0000075]"}
{"concept_id": "C1820192", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. [GOC:dph, GOC:jid]"}
{"concept_id": "C1820193", "aliases": [], "types": ["T044"], "canonical_name": "calcium-induced calcium release activity", "definition": "Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration. [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752]"}
{"concept_id": "C1820194", "aliases": [], "types": ["T043"], "canonical_name": "trichoblast maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state. [GOC:jid]"}
{"concept_id": "C1820195", "aliases": [], "types": ["T043"], "canonical_name": "root hair cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a root hair cell. [GOC:jid]"}
{"concept_id": "C1820196", "aliases": [], "types": ["T043"], "canonical_name": "root hair initiation", "definition": "The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth. [GOC:jid, PMID:12468740]"}
{"concept_id": "C1820197", "aliases": [], "types": ["T043"], "canonical_name": "root hair elongation", "definition": "The process in which the root hair grows longer. [GOC:jid, PMID:12468740]"}
{"concept_id": "C1820198", "aliases": ["root hair tip growth"], "types": ["T043"], "canonical_name": "root hair cell tip growth", "definition": "Localized growth of a plant root hair tip by extension of the cell wall. [GOC:jid, GOC:ki, PMID:12468740]"}
{"concept_id": "C1820199", "aliases": ["myofibril production"], "types": ["T043"], "canonical_name": "sarcomerogenesis", "definition": "The process in which sarcomeres are added in series within a fiber. [GOC:jid, GOC:lm, PMID:15947030]"}
{"concept_id": "C1820200", "aliases": [], "types": ["T026"], "canonical_name": "pigment granule", "definition": "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. [GOC:jid, GOC:mh]"}
{"concept_id": "C1820201", "aliases": [], "types": ["T038"], "canonical_name": "tissue remodeling", "definition": "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. [GOC:ebc]"}
{"concept_id": "C1820202", "aliases": ["leucophore cell differentiation"], "types": ["T043"], "canonical_name": "leucophore differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance. [GOC:jid, GOC:mh]"}
{"concept_id": "C1820203", "aliases": ["erythrophore cell differentiation"], "types": ["T043"], "canonical_name": "erythrophore differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance. [GOC:jid, GOC:mh]"}
{"concept_id": "C1820204", "aliases": ["cyanophore cell differentiation"], "types": ["T043"], "canonical_name": "cyanophore differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes. [GOC:jid, GOC:mh]"}
{"concept_id": "C1820205", "aliases": [], "types": ["T043"], "canonical_name": "regulation of leucophore differentiation", "definition": "Any process that modulates the frequency, rate or extent of leucophore differentiation. [GOC:mh]"}
{"concept_id": "C1820206", "aliases": ["down-regulation of leucophore differentiation", "down regulation of leucophore differentiation", "downregulation of leucophore differentiation"], "types": ["T043"], "canonical_name": "negative regulation of leucophore differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation. [GOC:mh]"}
{"concept_id": "C1820207", "aliases": ["upregulation of leucophore differentiation", "up-regulation of leucophore differentiation", "up regulation of leucophore differentiation"], "types": ["T043"], "canonical_name": "positive regulation of leucophore differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of leucophore differentiation. [GOC:mh]"}
{"concept_id": "C1820208", "aliases": [], "types": ["T043"], "canonical_name": "regulation of erythrophore differentiation", "definition": "Any process that modulates the frequency, rate or extent of erythrophore differentiation. [GOC:mh]"}
{"concept_id": "C1820209", "aliases": ["down regulation of erythrophore differentiation", "downregulation of erythrophore differentiation", "down-regulation of erythrophore differentiation"], "types": ["T043"], "canonical_name": "negative regulation of erythrophore differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrophore differentiation. [GOC:mh]"}
{"concept_id": "C1820210", "aliases": ["up regulation of erythrophore differentiation", "up-regulation of erythrophore differentiation", "upregulation of erythrophore differentiation"], "types": ["T043"], "canonical_name": "positive regulation of erythrophore differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation. [GOC:mh]"}
{"concept_id": "C1820211", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cyanophore differentiation", "definition": "Any process that modulates the frequency, rate or extent of cyanophore differentiation. [GOC:mh]"}
{"concept_id": "C1820212", "aliases": ["down regulation of cyanophore differentiation", "down-regulation of cyanophore differentiation", "downregulation of cyanophore differentiation"], "types": ["T043"], "canonical_name": "negative regulation of cyanophore differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cyanophore differentiation. [GOC:mh]"}
{"concept_id": "C1820213", "aliases": ["upregulation of cyanophore differentiation", "up-regulation of cyanophore differentiation", "up regulation of cyanophore differentiation"], "types": ["T043"], "canonical_name": "positive regulation of cyanophore differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation. [GOC:mh]"}
{"concept_id": "C1820214", "aliases": [], "types": ["T044"], "canonical_name": "pigment biosynthetic process during pigment granule maturation"}
{"concept_id": "C1820215", "aliases": [], "types": ["T042"], "canonical_name": "hatching gland development", "definition": "The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process. [GOC:bf, GOC:dh, GOC:jid]"}
{"concept_id": "C1820216", "aliases": ["pre-synaptic active zone", "presynaptic specialization"], "types": ["T026"], "canonical_name": "presynaptic active zone", "definition": "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]"}
{"concept_id": "C1820217", "aliases": ["active zone presynaptic plasma membrane", "active zone pre-synaptic plasma membrane", "active zone plasma membrane", "pre-synaptic active zone membrane"], "types": ["T026"], "canonical_name": "presynaptic active zone membrane", "definition": "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. [PMID:12812759, PMID:12923177, PMID:3152289]"}
{"concept_id": "C1820220", "aliases": ["cytoskeletal matrix organisation at active zone"], "types": ["T043"], "canonical_name": "cytoskeletal matrix organization at active zone", "definition": "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane. [GOC:dh, GOC:ef, GOC:jid, PMID:12812759]"}
{"concept_id": "C1820221", "aliases": ["maintenance of pre-synaptic active zone structure"], "types": ["T043"], "canonical_name": "maintenance of presynaptic active zone structure", "definition": "A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters. [GOC:curators, GOC:dph, GOC:pr]"}
{"concept_id": "C1820222", "aliases": [], "types": ["T043"], "canonical_name": "calcium ion-regulated exocytosis of neurotransmitter", "definition": "The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. [GOC:curators]"}
{"concept_id": "C1820223", "aliases": ["spontaneous synaptic vesicle exocytosis"], "types": ["T043"], "canonical_name": "spontaneous exocytosis of neurotransmitter", "definition": "The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell. [GOC:curators]"}
{"concept_id": "C1820224", "aliases": ["pronephric kidney development"], "types": ["T042"], "canonical_name": "pronephros development", "definition": "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151]"}
{"concept_id": "C1820225", "aliases": ["gas bladder development"], "types": ["T038"], "canonical_name": "swim bladder development", "definition": "The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. [GOC:mh]"}
{"concept_id": "C1820226", "aliases": ["gas bladder morphogenesis"], "types": ["T042"], "canonical_name": "swim bladder morphogenesis", "definition": "The process in which the anatomical structure of the swim bladder is generated and organized. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. [GOC:mh]"}
{"concept_id": "C1820227", "aliases": ["gas bladder maturation"], "types": ["T042"], "canonical_name": "swim bladder maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. [GOC:devbiol]"}
{"concept_id": "C1820228", "aliases": ["gas bladder biosynthesis", "gas bladder formation"], "types": ["T042"], "canonical_name": "swim bladder formation", "definition": "The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. [GOC:mh]"}
{"concept_id": "C1820229", "aliases": ["gas bladder inflation"], "types": ["T040"], "canonical_name": "swim bladder inflation", "definition": "The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. [GOC:mh]"}
{"concept_id": "C1820230", "aliases": [], "types": ["T042"], "canonical_name": "animal organ maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. [GOC:curators]"}
{"concept_id": "C1820231", "aliases": [], "types": ["T040"], "canonical_name": "antennal joint morphogenesis", "definition": "The process in which the anatomical structures of the antennal joint are generated and organized. [GOC:jid]"}
{"concept_id": "C1820232", "aliases": [], "types": ["T040"], "canonical_name": "notum morphogenesis", "definition": "The process in which the anatomical structures of the dorsal part of the body are generated and organized. [GOC:jid]"}
{"concept_id": "C1820234", "aliases": ["genital development"], "types": ["T038"], "canonical_name": "genitalia development", "definition": "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. [GOC:jid]"}
{"concept_id": "C1820235", "aliases": ["male genital morphogenesis"], "types": ["T042"], "canonical_name": "male genitalia morphogenesis", "definition": "The process in which the anatomical structures of male genitalia are generated and organized. [GOC:ems, ISBN:0140512888]"}
{"concept_id": "C1820236", "aliases": [], "types": ["T040"], "canonical_name": "analia morphogenesis", "definition": "The process in which the anatomical structures of analia are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster. [GOC:ai, GOC:mtg_sensu]"}
{"concept_id": "C1820238", "aliases": [], "types": ["T040"], "canonical_name": "dendrite morphogenesis", "definition": "The process in which the anatomical structures of a dendrite are generated and organized. [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]"}
{"concept_id": "C1820239", "aliases": [], "types": ["T038"], "canonical_name": "regulation of dendrite morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]"}
{"concept_id": "C1820240", "aliases": [], "types": ["T042"], "canonical_name": "hermaphrodite genitalia morphogenesis", "definition": "The process in which the anatomical structures of hermaphrodite genitalia are generated and organized. [GOC:ems, ISBN:0140512888]"}
{"concept_id": "C1820241", "aliases": [], "types": ["T040"], "canonical_name": "ocellus morphogenesis", "definition": "The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects. [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]"}
{"concept_id": "C1820242", "aliases": ["down-regulation of hair follicle maturation", "downregulation of hair follicle maturation", "down regulation of hair follicle maturation"], "types": ["T039"], "canonical_name": "negative regulation of hair follicle maturation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation. [GOC:devbiol]"}
{"concept_id": "C1820243", "aliases": ["upregulation of hair follicle maturation", "up-regulation of hair follicle maturation", "up regulation of hair follicle maturation"], "types": ["T039"], "canonical_name": "positive regulation of hair follicle maturation", "definition": "Any process that activates or increases the frequency, rate or extent of hair follicle maturation. [GOC:devbiol]"}
{"concept_id": "C1820244", "aliases": [], "types": ["T038"], "canonical_name": "regulation of hair follicle maturation", "definition": "Any process that modulates the frequency, rate or extent of hair follicle maturation. [GOC:devbiol]"}
{"concept_id": "C1820245", "aliases": [], "types": ["T042"], "canonical_name": "hair follicle maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state. [GOC:devbiol]"}
{"concept_id": "C1820246", "aliases": ["red blood cell development", "RBC development"], "types": ["T043"], "canonical_name": "erythrocyte development", "definition": "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. [GOC:devbiol]"}
{"concept_id": "C1820247", "aliases": ["enucleate RBC development", "enucleate red blood cell development"], "types": ["T043"], "canonical_name": "enucleate erythrocyte development", "definition": "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:devbiol]"}
{"concept_id": "C1820248", "aliases": ["nucleate red blood cell development", "nucleate RBC development"], "types": ["T043"], "canonical_name": "nucleate erythrocyte development", "definition": "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:devbiol]"}
{"concept_id": "C1820249", "aliases": ["chromatophore precursor differentiation"], "types": ["T043"], "canonical_name": "pigment cell precursor differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a pigment cell precursor. [GOC:dgh, PMID:16499899]"}
{"concept_id": "C1820250", "aliases": [], "types": ["T040"], "canonical_name": "cotyledon development", "definition": "The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling. [GOC:devbiol, GOC:tb, PO:0020030]"}
{"concept_id": "C1820251", "aliases": [], "types": ["T040"], "canonical_name": "cotyledon morphogenesis", "definition": "The process in which the anatomical structures of the cotyledon are generated and organized. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling. [GOC:devbiol, GOC:tb, PO:0020030]"}
{"concept_id": "C1820252", "aliases": ["collective phyllome structure development"], "types": ["T038"], "canonical_name": "phyllome development", "definition": "The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants. [GOC:devbiol, GOC:tb, PO:0006001]"}
{"concept_id": "C1820254", "aliases": [], "types": ["T042"], "canonical_name": "root cap development", "definition": "The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant. [GOC:tb]"}
{"concept_id": "C1820255", "aliases": [], "types": ["T040"], "canonical_name": "adventitious root development", "definition": "The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot. [GOC:tb]"}
{"concept_id": "C1820256", "aliases": ["regulation of shoot development"], "types": ["T038"], "canonical_name": "regulation of shoot system development", "definition": "Any process that modulates the frequency, rate or extent of shoot development. [GOC:tb, PMID:16361392]"}
{"concept_id": "C1820258", "aliases": [], "types": ["T038"], "canonical_name": "specification of floral organ number", "definition": "Any process that modulates the number of floral organs formed in a floral whorl. [GOC:tb]"}
{"concept_id": "C1820259", "aliases": [], "types": ["T038"], "canonical_name": "specification of petal number", "definition": "Any process that modulates the number of petals formed in a flower. [GOC:tb]"}
{"concept_id": "C1820260", "aliases": [], "types": ["T038"], "canonical_name": "specification of decreased petal number", "definition": "Any process that reduces the number of petals produced in a developing flower. [GOC:tb]"}
{"concept_id": "C1820261", "aliases": [], "types": ["T042"], "canonical_name": "specification of increased petal number", "definition": "Any process that increases the number of petals produced in a developing flower. [GOC:tb]"}
{"concept_id": "C1820262", "aliases": ["sorocarp sorus formation", "sorocarp spore head formation"], "types": ["T040"], "canonical_name": "sorocarp sorus development", "definition": "The process whose specific outcome is the progression of the sorocarp sorus over time, from its formation to the mature structure. A sorocarp sorus is the spore containing structure of a sorocarp. [GOC:devbiol, GOC:mtg_sensu, PMID:4332228]"}
{"concept_id": "C1820263", "aliases": [], "types": ["T042"], "canonical_name": "release of seed from dormancy", "definition": "The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release. [GOC:dph, GOC:jid, GOC:tb, ISBN:9781405139830]"}
{"concept_id": "C1820264", "aliases": [], "types": ["T042"], "canonical_name": "inner ear development", "definition": "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. [GOC:sr]"}
{"concept_id": "C1820265", "aliases": [], "types": ["T042"], "canonical_name": "otolith development", "definition": "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure. [GOC:sr]"}
{"concept_id": "C1820266", "aliases": [], "types": ["T043"], "canonical_name": "regulation of axon extension involved in axon guidance", "definition": "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. [GOC:devbiol]"}
{"concept_id": "C1820267", "aliases": ["upregulation of axon extension involved in axon guidance", "up regulation of axon extension involved in axon guidance", "up-regulation of axon extension involved in axon guidance"], "types": ["T043"], "canonical_name": "positive regulation of axon extension involved in axon guidance", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance. [GOC:devbiol]"}
{"concept_id": "C1820268", "aliases": ["down regulation of axon extension involved in axon guidance", "down-regulation of axon extension involved in axon guidance", "downregulation of axon extension involved in axon guidance"], "types": ["T043"], "canonical_name": "negative regulation of axon extension involved in axon guidance", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. [GOC:devbiol]"}
{"concept_id": "C1820269", "aliases": ["arterial morphogenesis", "arteriogenesis"], "types": ["T042"], "canonical_name": "artery morphogenesis", "definition": "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. [GOC:dsf, PMID:16740480]"}
{"concept_id": "C1820270", "aliases": ["venous morphogenesis"], "types": ["T042"], "canonical_name": "venous blood vessel morphogenesis", "definition": "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. [GOC:dsf, PMID:16740480]"}
{"concept_id": "C1820271", "aliases": [], "types": ["T042"], "canonical_name": "vein morphogenesis"}
{"concept_id": "C1820272", "aliases": [], "types": ["T042"], "canonical_name": "axon extension involved in axon guidance", "definition": "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. [GOC:ef, GOC:jid]"}
{"concept_id": "C1820273", "aliases": ["adenophysis biosynthesis", "anterior pituitary gland biosynthesis", "anterior pituitary gland formation", "anterior pituitary formation", "adenophysis formation", "anterior pituitary biosynthesis"], "types": ["T040"], "canonical_name": "adenohypophysis formation", "definition": "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1820274", "aliases": ["posterior pituitary morphogenesis", "posterior pituitary gland morphogenesis", "neurophysis morphogenesis"], "types": ["T040"], "canonical_name": "neurohypophysis morphogenesis", "definition": "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1820275", "aliases": ["neurophysis formation", "posterior pituitary biosynthesis", "posterior pituitary gland formation", "neurophysis biosynthesis", "posterior pituitary formation", "posterior pituitary gland biosynthesis"], "types": ["T040"], "canonical_name": "neurohypophysis formation", "definition": "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1820276", "aliases": ["pituitary gland morphogenesis"], "types": ["T040"], "canonical_name": "hypophysis morphogenesis", "definition": "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1820277", "aliases": ["hypophysis biosynthesis", "pituitary gland formation", "pituitary gland biosynthesis"], "types": ["T040"], "canonical_name": "hypophysis formation", "definition": "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands. [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1820278", "aliases": [], "types": ["T040"], "canonical_name": "diencephalon morphogenesis", "definition": "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]"}
{"concept_id": "C1820279", "aliases": ["prosencephalon morphogenesis"], "types": ["T040"], "canonical_name": "forebrain morphogenesis", "definition": "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1820280", "aliases": [], "types": ["T042"], "canonical_name": "brain morphogenesis", "definition": "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dgh, GOC:jid]"}
{"concept_id": "C1820281", "aliases": ["anterior pituitary gland morphogenesis", "adenophysis morphogenesis", "anterior pituitary morphogenesis"], "types": ["T040"], "canonical_name": "adenohypophysis morphogenesis", "definition": "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C1820282", "aliases": ["development of an anatomical structure"], "types": ["T042"], "canonical_name": "anatomical structure development", "definition": "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GO_REF:0000021]"}
{"concept_id": "C1820283", "aliases": [], "types": ["T042"], "canonical_name": "neural nucleus development", "definition": "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. [GO_REF:0000021]"}
{"concept_id": "C1820284", "aliases": [], "types": ["T040"], "canonical_name": "cell projection morphogenesis", "definition": "The process in which the anatomical structures of a cell projection are generated and organized. [GO_REF:0000021]"}
{"concept_id": "C1820285", "aliases": [], "types": ["T040"], "canonical_name": "formation of anatomical boundary", "definition": "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GO_REF:0000021]"}
{"concept_id": "C1820286", "aliases": [], "types": ["T043"], "canonical_name": "glioblast division", "definition": "The process resulting in the physical partitioning and separation of a glioblast into daughter cells. [GOC:devbiol]"}
{"concept_id": "C1820287", "aliases": ["leukemia inhibitory factor signalling pathway"], "types": ["T044"], "canonical_name": "leukemia inhibitory factor signaling pathway", "definition": "The series of molecular signals initiated by the binding of a leukemia inhibitory factor to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:devbiol, GOC:signaling]"}
{"concept_id": "C1820289", "aliases": [], "types": ["T043"], "canonical_name": "stem cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell. [CL:0000034, GOC:isa_complete]"}
{"concept_id": "C1820290", "aliases": [], "types": ["T043"], "canonical_name": "stem cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [CL:0000034, GOC:isa_complete]"}
{"concept_id": "C1820291", "aliases": [], "types": ["T043"], "canonical_name": "stem cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed. [CL:0000034, GOC:isa_complete]"}
{"concept_id": "C1820292", "aliases": [], "types": ["T039"], "canonical_name": "pollen tube development", "definition": "The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure. [GOC:isa_complete]"}
{"concept_id": "C1820293", "aliases": [], "types": ["T043"], "canonical_name": "cellular developmental process", "definition": "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. [GOC:isa_complete]"}
{"concept_id": "C1820295", "aliases": [], "types": ["T038"], "canonical_name": "multicellular organismal homeostasis", "definition": "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. [GOC:isa_complete]"}
{"concept_id": "C1820296", "aliases": ["cell population homeostasis", "homeostasis of cell number"], "types": ["T038"], "canonical_name": "homeostasis of number of cells", "definition": "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. [GOC:isa_complete]"}
{"concept_id": "C1820297", "aliases": [], "types": ["T040"], "canonical_name": "homeostasis of number of cells within a tissue", "definition": "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. [GOC:isa_complete]"}
{"concept_id": "C1820298", "aliases": [], "types": ["T038"], "canonical_name": "homeostasis of number of cells in a free-living population"}
{"concept_id": "C1820299", "aliases": [], "types": ["T040"], "canonical_name": "chemical homeostasis within a tissue", "definition": "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. [GOC:isa_complete]"}
{"concept_id": "C1820302", "aliases": [], "types": ["T038"], "canonical_name": "chemical homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of a chemical. [GOC:isa_complete]"}
{"concept_id": "C1820303", "aliases": [], "types": ["T042"], "canonical_name": "sensory system development", "definition": "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. [GOC:dgh]"}
{"concept_id": "C1820304", "aliases": ["LL system development"], "types": ["T040"], "canonical_name": "mechanosensory lateral line system development", "definition": "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. [ISBN:0125296509]"}
{"concept_id": "C1820305", "aliases": ["LL development"], "types": ["T042"], "canonical_name": "lateral line development", "definition": "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear. [ISBN:0125296509]"}
{"concept_id": "C1820306", "aliases": ["lateral line primordium migration"], "types": ["T043"], "canonical_name": "neuromast primordium migration", "definition": "The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop. [PMID:15018940, PMID:15832385]"}
{"concept_id": "C1820307", "aliases": [], "types": ["T042"], "canonical_name": "neuromast development", "definition": "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals. [ISBN:0125296509]"}
{"concept_id": "C1820308", "aliases": [], "types": ["T043"], "canonical_name": "neuromast deposition", "definition": "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line. [PMID:15018940]"}
{"concept_id": "C1820309", "aliases": [], "types": ["T043"], "canonical_name": "neuromast hair cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. [CL:0000856, ISBN:0125296509]"}
{"concept_id": "C1820310", "aliases": [], "types": ["T042"], "canonical_name": "cupula development", "definition": "The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. [ISBN:0125296509]"}
{"concept_id": "C1820311", "aliases": [], "types": ["T043"], "canonical_name": "neuromast mantle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. [ISBN:0125296509]"}
{"concept_id": "C1820312", "aliases": [], "types": ["T043"], "canonical_name": "neuromast support cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. [ISBN:0125296509]"}
{"concept_id": "C1820313", "aliases": ["gLL ganglion development"], "types": ["T042"], "canonical_name": "lateral line ganglion development", "definition": "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear. [ISBN:0125296509, ISBN:0387968377]"}
{"concept_id": "C1820314", "aliases": ["gLL neuron differentiation"], "types": ["T043"], "canonical_name": "lateral line ganglion neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron. [PMID:15018940]"}
{"concept_id": "C1820315", "aliases": ["nLL development"], "types": ["T042"], "canonical_name": "lateral line nerve development", "definition": "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. [ISBN:0125296509]"}
{"concept_id": "C1820316", "aliases": [], "types": ["T042"], "canonical_name": "afferent axon development in lateral line nerve", "definition": "The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve. [PMID:15832385]"}
{"concept_id": "C1820317", "aliases": [], "types": ["T042"], "canonical_name": "efferent axon development in a lateral line nerve", "definition": "The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve. [PMID:15832385]"}
{"concept_id": "C1820318", "aliases": [], "types": ["T043"], "canonical_name": "lateral line nerve glial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve. [PMID:12062041]"}
{"concept_id": "C1820319", "aliases": ["glial cell migration in lateral line nerve"], "types": ["T043"], "canonical_name": "lateral line nerve glial cell migration", "definition": "The movement of a glial cell along the axons in a lateral line nerve. [PMID:12062041]"}
{"concept_id": "C1820320", "aliases": [], "types": ["T042"], "canonical_name": "myelination of lateral line nerve axons", "definition": "The formation of compact myelin sheaths around the axons of a lateral line nerve. [PMID:12112375]"}
{"concept_id": "C1820321", "aliases": [], "types": ["T040"], "canonical_name": "anterior lateral line system development", "definition": "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. [ISBN:0125296509, PMID:15018940]"}
{"concept_id": "C1820322", "aliases": [], "types": ["T040"], "canonical_name": "ALL system development"}
{"concept_id": "C1820323", "aliases": ["anterior LL development"], "types": ["T042"], "canonical_name": "anterior lateral line development", "definition": "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear. [ISBN:0125296509]"}
{"concept_id": "C1820324", "aliases": ["ALL neuromast primordium migration"], "types": ["T043"], "canonical_name": "anterior lateral line neuromast primordium migration", "definition": "The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop. [GOC:dgh, PMID:15832385]"}
{"concept_id": "C1820325", "aliases": [], "types": ["T042"], "canonical_name": "anterior lateral line neuromast development", "definition": "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals. [ISBN:0125296509]"}
{"concept_id": "C1820326", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line neuromast deposition", "definition": "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line. [PMID:15832385]"}
{"concept_id": "C1820327", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line neuromast hair cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. [ISBN:0125296509, ISBN:0387968377]"}
{"concept_id": "C1820328", "aliases": [], "types": ["T042"], "canonical_name": "anterior lateral line neuromast cupula development", "definition": "The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. [ISBN:0125296509]"}
{"concept_id": "C1820329", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line neuromast mantle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. [ISBN:0125296509]"}
{"concept_id": "C1820330", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line neuromast support cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. [ISBN:0387968377]"}
{"concept_id": "C1820331", "aliases": ["gALL development"], "types": ["T042"], "canonical_name": "anterior lateral line ganglion development", "definition": "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear. [ISBN:0125296509]"}
{"concept_id": "C1820332", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line ganglion neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion. [PMID:15018940]"}
{"concept_id": "C1820333", "aliases": ["ALLN development", "nALL development", "rostral lateral line nerve development"], "types": ["T042"], "canonical_name": "anterior lateral line nerve development", "definition": "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0125296509]"}
{"concept_id": "C1820334", "aliases": [], "types": ["T042"], "canonical_name": "afferent axon development in anterior lateral line nerve", "definition": "The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve. [PMID:15018940]"}
{"concept_id": "C1820335", "aliases": [], "types": ["T042"], "canonical_name": "efferent axon development in anterior lateral line nerve", "definition": "The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve. [PMID:15018940]"}
{"concept_id": "C1820336", "aliases": [], "types": ["T043"], "canonical_name": "glial cell migration in anterior lateral line nerve", "definition": "The movement of a glial cell along the axons in the anterior lateral line nerve. [PMID:12062041]"}
{"concept_id": "C1820337", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line nerve glial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve. [PMID:15832385]"}
{"concept_id": "C1820338", "aliases": [], "types": ["T042"], "canonical_name": "myelination of anterior lateral line nerve axons", "definition": "The formation of compact myelin sheaths around the axons of the anterior lateral line nerve. [PMID:12112375]"}
{"concept_id": "C1820339", "aliases": ["PLL"], "types": ["T040"], "definition": "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. [ISBN:0125296509, PMID:15018940]", "canonical_name": "posterior lateral line system development"}
{"concept_id": "C1820340", "aliases": ["PLL development"], "types": ["T042"], "canonical_name": "posterior lateral line development", "definition": "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear. [ISBN:0125296509]"}
{"concept_id": "C1820341", "aliases": ["gPLL development"], "types": ["T042"], "canonical_name": "posterior lateral line ganglion development", "definition": "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear. [ISBN:0125296509, ISBN:0387968377]"}
{"concept_id": "C1820342", "aliases": ["PLLN development", "caudal lateral line nerve development"], "types": ["T042"], "canonical_name": "posterior lateral line nerve development", "definition": "The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0125296509]"}
{"concept_id": "C1820343", "aliases": [], "types": ["T042"], "canonical_name": "posterior lateral line neuromast development", "definition": "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals. [ISBN:0125296509]"}
{"concept_id": "C1820344", "aliases": ["PLL neuromast primordium migration"], "types": ["T043"], "canonical_name": "posterior lateral line neuromast primordium migration", "definition": "The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop. [GOC:dgh, PMID:15832385]"}
{"concept_id": "C1820345", "aliases": [], "types": ["T042"], "canonical_name": "posterior lateral line neuromast cupula development", "definition": "The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. [ISBN:0125296509]"}
{"concept_id": "C1820346", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line neuromast deposition", "definition": "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line. [PMID:15832385]"}
{"concept_id": "C1820347", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line neuromast hair cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. [ISBN:0125296509]"}
{"concept_id": "C1820348", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line neuromast mantle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. [ISBN:0125296509]"}
{"concept_id": "C1820349", "aliases": [], "types": ["T042"], "canonical_name": "lateral line system development", "definition": "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear. [GOC:dgh, ISBN:0125296509]"}
{"concept_id": "C1820350", "aliases": [], "types": ["T040"], "canonical_name": "electrosensory lateral line system development", "definition": "The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure. [GOC:dgh]"}
{"concept_id": "C1820351", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line neuromast support cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. [ISBN:0387968377]"}
{"concept_id": "C1820352", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line ganglion neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion. [PMID:15018940]"}
{"concept_id": "C1820353", "aliases": [], "types": ["T042"], "canonical_name": "efferent axon development in posterior lateral line nerve", "definition": "The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve. [PMID:15018940]"}
{"concept_id": "C1820354", "aliases": [], "types": ["T043"], "canonical_name": "glial cell migration in posterior lateral line nerve", "definition": "The movement of a glial cell along the axons in the posterior lateral line nerve. [PMID:12062041]"}
{"concept_id": "C1820355", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line nerve glial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve. [PMID:15832385]"}
{"concept_id": "C1820356", "aliases": [], "types": ["T042"], "canonical_name": "myelination of posterior lateral line nerve axons", "definition": "The formation of compact myelin sheaths around the axons of the posterior lateral line nerve. [PMID:12112375]"}
{"concept_id": "C1820357", "aliases": [], "types": ["T042"], "canonical_name": "afferent axon development in posterior lateral line nerve", "definition": "The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve. [PMID:15018940]"}
{"concept_id": "C1820358", "aliases": [], "types": ["T043"], "canonical_name": "peripheral nervous system neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. [GOC:dgh]"}
{"concept_id": "C1820359", "aliases": [], "types": ["T043"], "canonical_name": "peripheral nervous system neuron development", "definition": "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. [GOC:dgh]"}
{"concept_id": "C1820360", "aliases": [], "types": ["T042"], "canonical_name": "peripheral nervous system neuron axonogenesis", "definition": "Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells. [GOC:dgh]"}
{"concept_id": "C1820361", "aliases": [], "types": ["T043"], "canonical_name": "lateral line nerve glial cell development", "definition": "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dgh]"}
{"concept_id": "C1820363", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line nerve glial cell development", "definition": "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dgh]"}
{"concept_id": "C1820365", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line nerve glial cell development", "definition": "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dgh]"}
{"concept_id": "C1820367", "aliases": ["acetylenemonocarboxylate hydratase activity"], "types": ["T044"], "canonical_name": "acetylenemonocarboxylate hydratase activity"}
{"concept_id": "C1820368", "aliases": ["alkynoate hydratase activity"], "types": ["T044"], "canonical_name": "alkynoate hydratase activity"}
{"concept_id": "C1820369", "aliases": ["tectum"], "types": ["T026"], "definition": "The layer of sexine which forms a roof over the columella, granules or other infratectal elements. [http://www.mobot.org/MOBOT/research/APweb/]", "canonical_name": "sexine 2"}
{"concept_id": "C1820370", "aliases": [], "types": ["T040"], "canonical_name": "flowering"}
{"concept_id": "C1820371", "aliases": [], "types": ["T045"], "definition": "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. [GOC:jp, ISBN:1555812090]", "canonical_name": "transposition"}
{"concept_id": "C1820372", "aliases": ["columella"], "types": ["T026"], "definition": "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella). [http://www.mobot.org/MOBOT/research/APweb/]", "canonical_name": "sexine 1"}
{"concept_id": "C1820373", "aliases": ["PAS"], "types": ["T026"], "canonical_name": "pre-autophagosomal structure"}
{"concept_id": "C1820375", "aliases": ["parahippocampal gyrus development"], "types": ["T042"], "definition": "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]", "canonical_name": "hippocampal gyrus development"}
{"concept_id": "C1820376", "aliases": ["bleb"], "types": ["T026"], "definition": "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]", "canonical_name": "plasma membrane bleb"}
{"concept_id": "C1820377", "aliases": [], "types": ["T046"], "definition": "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors. [GOC:add, ISBN:0781735149]", "canonical_name": "type II hypersensitivity"}
{"concept_id": "C1826983", "aliases": [], "types": ["T044"], "canonical_name": "5-methyltetrahydrofolate-homocysteine methyltransferase reductase"}
{"concept_id": "C1828470", "aliases": ["horsetail-astral microtubule array"], "types": ["T026"], "definition": "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement. [GOC:mah, PMID:16111942]", "canonical_name": "HAA"}
{"concept_id": "C1828471", "aliases": [], "types": ["T044"], "canonical_name": "chain migration"}
{"concept_id": "C1879542", "aliases": [], "types": ["T043"], "definition": "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. [GOC:dph, GOC:tb]", "canonical_name": "acinar cell differentiation"}
{"concept_id": "C1953345", "aliases": ["chromosome region"], "types": ["T026"], "definition": "Any subdivision of a chromosome along its length. [GOC:dos]", "canonical_name": "chromosomal region"}
{"concept_id": "C1955896", "aliases": [], "types": ["T030"], "canonical_name": "electrotonic synapse"}
{"concept_id": "C1956015", "aliases": [], "types": ["T026"], "definition": "The two dissimilar sized ribonucleoprotein complexes that comprise a RIBOSOME - the large ribosomal subunit and the small ribosomal subunit. The eukaryotic 80S ribosome is composed of a 60S large subunit and a 40S small subunit. The bacterial 70S ribosome is composed of a 50S large subunit and a 30S small subunit.", "canonical_name": "ribosomal subunit"}
{"concept_id": "C1979804", "aliases": [], "types": ["T043"], "canonical_name": "serotonin release"}
{"concept_id": "C1980004", "aliases": [], "types": ["T023"], "canonical_name": "tail tip"}
{"concept_id": "C1999107", "aliases": [], "types": ["T039"], "definition": "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. [GOC:mtg_cardio]", "canonical_name": "circulatory system process"}
{"concept_id": "C2243134", "aliases": [], "types": ["T044"], "canonical_name": "15-OH-PGDH"}
{"concept_id": "C2243152", "aliases": ["-C-C-A pyrophosphorylase"], "types": ["T045"], "canonical_name": "-C-C-A pyrophosphorylase"}
{"concept_id": "C2243153", "aliases": ["ATP (CTP):tRNA nucleotidyltransferase", "ATP(CTP)-tRNA nucleotidyltransferase activity", "ATP(CTP):tRNA nucleotidyltransferase activity", "ATP(CTP)-tRNA nucleotidyltransferase"], "types": ["T045"], "canonical_name": "CTP(ATP):tRNA nucleotidyltransferase activity"}
{"concept_id": "C2243154", "aliases": ["ribonucleic cytidylic cytidylic adenylic pyrophosphorylase"], "types": ["T045"], "canonical_name": "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase"}
{"concept_id": "C2243155", "aliases": ["ribonucleic cytidylyltransferase"], "types": ["T045"], "canonical_name": "ribonucleic cytidylyltransferase"}
{"concept_id": "C2243156", "aliases": ["transfer ribonucleate adenylyltransferase"], "types": ["T045"], "canonical_name": "transfer ribonucleate adenylyltransferase"}
{"concept_id": "C2243157", "aliases": ["transfer ribonucleate cytidylyltransferase"], "types": ["T045"], "canonical_name": "transfer ribonucleate cytidylyltransferase"}
{"concept_id": "C2243158", "aliases": ["transfer ribonucleate nucleotidyltransferase"], "types": ["T045"], "canonical_name": "transfer ribonucleate nucleotidyltransferase"}
{"concept_id": "C2243159", "aliases": ["transfer ribonucleic acid nucleotidyl transferase"], "types": ["T045"], "canonical_name": "transfer ribonucleic acid nucleotidyl transferase"}
{"concept_id": "C2243160", "aliases": ["transfer ribonucleic adenylyl (cytidylyl) transferase"], "types": ["T045"], "canonical_name": "transfer ribonucleic adenylyl (cytidylyl) transferase"}
{"concept_id": "C2243161", "aliases": ["transfer ribonucleic-terminal trinucleotide nucleotidyltransferase"], "types": ["T045"], "canonical_name": "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase"}
{"concept_id": "C2243162", "aliases": ["tRNA adenylyl(cytidylyl)transferase"], "types": ["T045"], "canonical_name": "tRNA adenylyl(cytidylyl)transferase"}
{"concept_id": "C2243163", "aliases": ["tRNA CCA-diphosphorylase activity"], "types": ["T045"], "canonical_name": "tRNA CCA-diphosphorylase activity"}
{"concept_id": "C2243164", "aliases": ["tRNA CCA-pyrophosphorylase activity"], "types": ["T045"], "canonical_name": "tRNA CCA-pyrophosphorylase activity"}
{"concept_id": "C2243170", "aliases": ["tRNA-uridine uracilmutase activity", "transfer RNA pseudouridine synthetase activity", "tRNA-uridine isomerase activity", "transfer ribonucleate pseudouridine synthetase activity", "tRNA-pseudouridine synthase activity"], "types": ["T044"], "canonical_name": "tRNA pseudouridine synthase activity", "definition": "Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [PMID:11095668]"}
{"concept_id": "C2243172", "aliases": [], "types": ["T044"], "canonical_name": "P(1B)-type ATPase activity"}
{"concept_id": "C2243180", "aliases": ["vacuolar hydrogen-translocating V-type ATPase complex", "vacuolar hydrogen-translocating V-type ATPase complex location", "vacuolar proton-transporting V-type ATPase complex location"], "types": ["T026"], "canonical_name": "vacuolar proton-transporting V-type ATPase complex", "definition": "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. [GOC:mah, ISBN:0716743663, PMID:16449553]"}
{"concept_id": "C2243181", "aliases": [], "types": ["T043"], "canonical_name": "regulation of embryonic cell shape", "definition": "Any process that modulates the surface configuration of an embryonic cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2243183", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription from RNA polymerase I promoter"}
{"concept_id": "C2243185", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription from RNA polymerase III promoter"}
{"concept_id": "C2243194", "aliases": [], "types": ["T045"], "canonical_name": "mRNA editing"}
{"concept_id": "C2243196", "aliases": ["CDK8-containing TRAP/mediator complex location"], "types": ["T026"], "canonical_name": "CDK8-containing TRAP/mediator complex"}
{"concept_id": "C2243200", "aliases": [], "types": ["T044"], "canonical_name": "glutaminyl-tRNA cyclotransferase activity"}
{"concept_id": "C2243210", "aliases": [], "types": ["T044"], "canonical_name": "NAD-linked malic enzyme"}
{"concept_id": "C2243211", "aliases": [], "types": ["T044"], "canonical_name": "NAD-malic enzyme activity"}
{"concept_id": "C2243212", "aliases": [], "types": ["T044"], "canonical_name": "NAD-specific malic enzyme"}
{"concept_id": "C2243234", "aliases": ["1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity", "1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH. [EC:1.1.1.292, RHEA:24208]", "canonical_name": "AFR"}
{"concept_id": "C2243253", "aliases": [], "types": ["T044"], "canonical_name": "peroxidase-M2"}
{"concept_id": "C2243258", "aliases": [], "types": ["T044"], "canonical_name": "ligninase I activity"}
{"concept_id": "C2243265", "aliases": [], "types": ["T044"], "canonical_name": "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)"}
{"concept_id": "C2243266", "aliases": [], "types": ["T044"], "canonical_name": "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)"}
{"concept_id": "C2243268", "aliases": [], "types": ["T044"], "canonical_name": "CA4H activity"}
{"concept_id": "C2243287", "aliases": [], "types": ["T044"], "canonical_name": "crepenynate synthase activity"}
{"concept_id": "C2243291", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on CH or CH2 groups", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C2243292", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on CH or CH2 groups, other acceptors"}
{"concept_id": "C2243373", "aliases": ["myosin I heavy chain kinase activity"], "types": ["T044"], "canonical_name": "myosin I heavy-chain kinase activity"}
{"concept_id": "C2243374", "aliases": ["myosin II heavy chain kinase activity"], "types": ["T044"], "canonical_name": "myosin II heavy-chain kinase activity"}
{"concept_id": "C2243406", "aliases": [], "types": ["T044"], "canonical_name": "carboxydismutase activity"}
{"concept_id": "C2243419", "aliases": [], "types": ["T044"], "canonical_name": "beta-mannanase activity"}
{"concept_id": "C2243420", "aliases": [], "types": ["T044"], "canonical_name": "beta-mannanase B"}
{"concept_id": "C2243422", "aliases": [], "types": ["T044"], "canonical_name": "endo-1,4-mannanase activity"}
{"concept_id": "C2243423", "aliases": [], "types": ["T044"], "canonical_name": "endo-beta-mannanase activity"}
{"concept_id": "C2243434", "aliases": [], "types": ["T044"], "canonical_name": "hydrogenobyrinic acid-binding protein activity"}
{"concept_id": "C2243443", "aliases": ["alpha-2,8-sialosylhydrolase activity", "endo-N-acylneuraminidase activity", "endosialidase activity", "endo-N-acetylneuraminidase activity", "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity", "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity", "polysialoside (2->8)-alpha-sialosylhydrolase activity", "endoneuraminidase activity"], "types": ["T044"], "canonical_name": "endo-alpha-(2,8)-sialidase activity", "definition": "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids. [EC:3.2.1.129]"}
{"concept_id": "C2243451", "aliases": ["dual-specificity MAP kinase phosphatase activity"], "types": ["T044"], "canonical_name": "MAP kinase tyrosine/serine/threonine phosphatase activity", "definition": "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. [GOC:mah, PMID:12184814]"}
{"concept_id": "C2243480", "aliases": ["(Lea)-dependent (alpha-3/4)-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity"}
{"concept_id": "C2243484", "aliases": [], "types": ["T044"], "canonical_name": "alpha-(1,3/1,4) fucosyltransferase III activity"}
{"concept_id": "C2243485", "aliases": [], "types": ["T044"], "canonical_name": "alpha-4-L-fucosyltransferase activity"}
{"concept_id": "C2243486", "aliases": [], "types": ["T044"], "canonical_name": "beta-acetylglucosaminylsaccharide fucosyltransferase activity"}
{"concept_id": "C2243487", "aliases": [], "types": ["T044"], "canonical_name": "blood group Lewis alpha-4-fucosyltransferase activity"}
{"concept_id": "C2243488", "aliases": [], "types": ["T044"], "canonical_name": "blood-group substance Le(a)-dependent fucosyltransferase activity"}
{"concept_id": "C2243489", "aliases": [], "types": ["T044"], "canonical_name": "blood-group substance Lea-dependent fucosyltransferase"}
{"concept_id": "C2243490", "aliases": [], "types": ["T044"], "canonical_name": "FucT-II activity"}
{"concept_id": "C2243497", "aliases": ["Lewis alpha-(1,3/4)-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "Lewis alpha-(1->3/4)-fucosyltransferase activity"}
{"concept_id": "C2243498", "aliases": ["Lewis blood group alpha-(1,3/4)-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity"}
{"concept_id": "C2243499", "aliases": [], "types": ["T044"], "canonical_name": "Lewis FT activity"}
{"concept_id": "C2243501", "aliases": ["Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity"}
{"concept_id": "C2243510", "aliases": [], "types": ["T044"], "canonical_name": "aryl sulfotransferase IV"}
{"concept_id": "C2243521", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial uncoupling protein activity"}
{"concept_id": "C2243528", "aliases": [], "types": ["T044"], "canonical_name": "plasma alpha-3-fucosyltransferase activity"}
{"concept_id": "C2243537", "aliases": ["Gal-1-P uridylyltransferase activity"], "types": ["T044"], "canonical_name": "Gal-1-P uridylyltransferase activity"}
{"concept_id": "C2243544", "aliases": [], "types": ["T044"], "canonical_name": "inosine 5'-diphosphatase"}
{"concept_id": "C2243549", "aliases": [], "types": ["T044"], "canonical_name": "type B nucleoside diphosphatase"}
{"concept_id": "C2243550", "aliases": [], "types": ["T044"], "canonical_name": "type L nucleoside diphosphatase"}
{"concept_id": "C2243562", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein biosynthetic process"}
{"concept_id": "C2243592", "aliases": [], "types": ["T044"], "canonical_name": "protein methylase 3 activity"}
{"concept_id": "C2243593", "aliases": [], "types": ["T044"], "canonical_name": "protein methylase III activity"}
{"concept_id": "C2243594", "aliases": [], "types": ["T044"], "canonical_name": "protein methyltransferase II activity"}
{"concept_id": "C2243600", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-cysteine deamination", "definition": "The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. [RESID:AA0127]"}
{"concept_id": "C2243603", "aliases": [], "types": ["T044"], "canonical_name": "protein methylase IV activity"}
{"concept_id": "C2243623", "aliases": ["aryl-alcohol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "aryl-alcohol dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+. [EC:1.1.1.90]"}
{"concept_id": "C2243624", "aliases": [], "types": ["T044"], "canonical_name": "p-hydroxybenzyl alcohol dehydrogenase activity"}
{"concept_id": "C2243639", "aliases": ["L(+)-mandelate dehydrogenase activity", "MDH", "(S)-mandelate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor. [EC:1.1.99.31]", "canonical_name": "(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity"}
{"concept_id": "C2243640", "aliases": [], "types": ["T044"], "canonical_name": "primary alcohol dehydrogenase"}
{"concept_id": "C2243659", "aliases": ["4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)"], "types": ["T044"], "canonical_name": "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)"}
{"concept_id": "C2243724", "aliases": [], "types": ["T044"], "canonical_name": "desulfofuscidin activity"}
{"concept_id": "C2243725", "aliases": [], "types": ["T044"], "canonical_name": "desulforubidin activity"}
{"concept_id": "C2243726", "aliases": [], "types": ["T044"], "canonical_name": "desulfoviridin activity"}
{"concept_id": "C2243730", "aliases": [], "types": ["T044"], "canonical_name": "catechase activity"}
{"concept_id": "C2243733", "aliases": [], "types": ["T044"], "canonical_name": "pyrocatechase activity"}
{"concept_id": "C2243739", "aliases": [], "types": ["T044"], "canonical_name": "cato2ase activity"}
{"concept_id": "C2243740", "aliases": [], "types": ["T044"], "canonical_name": "metapyrocatechase activity"}
{"concept_id": "C2243742", "aliases": [], "types": ["T044"], "canonical_name": "protocatechuate oxygenase activity"}
{"concept_id": "C2243755", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxy-2-naphthoate-degrading enzyme activity"}
{"concept_id": "C2243758", "aliases": [], "types": ["T044"], "canonical_name": "2,3-dihydroxybiphenyl dioxygenase activity"}
{"concept_id": "C2243766", "aliases": [], "types": ["T044"], "canonical_name": "anthranilate 1,2-dioxygenase"}
{"concept_id": "C2243768", "aliases": [], "types": ["T044"], "canonical_name": "anthranilate dioxygenase reductase"}
{"concept_id": "C2243769", "aliases": ["anthranilate hydroxylase activity"], "types": ["T044"], "canonical_name": "anthranilate hydroxylase activity"}
{"concept_id": "C2243771", "aliases": [], "types": ["T044"], "canonical_name": "anthranilic acid hydroxylase activity"}
{"concept_id": "C2243772", "aliases": [], "types": ["T044"], "canonical_name": "anthranilic hydroxylase activity"}
{"concept_id": "C2243774", "aliases": [], "types": ["T044"], "canonical_name": "benzene hydroxylase activity"}
{"concept_id": "C2243777", "aliases": [], "types": ["T044"], "canonical_name": "phthalate dioxygenase activity"}
{"concept_id": "C2243779", "aliases": [], "types": ["T044"], "canonical_name": "4-sulfobenzoate 3,4-dioxygenase system"}
{"concept_id": "C2243820", "aliases": [], "types": ["T044"], "canonical_name": "4 HPA 3-hydroxylase activity"}
{"concept_id": "C2243821", "aliases": [], "types": ["T044"], "canonical_name": "p-hydroxyphenylacetate 3-hydroxylase activity"}
{"concept_id": "C2243822", "aliases": [], "types": ["T044"], "canonical_name": "p-hydroxyphenylacetate hydroxylase activity"}
{"concept_id": "C2243859", "aliases": ["(S)-limonene 7-monooxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+). [EC:1.14.14.52, RHEA:23432]", "canonical_name": "(-)-limonene 7-monooxygenase activity"}
{"concept_id": "C2243889", "aliases": ["fatty acid omega-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:krc, PMID:18544608, RHEA:56748]", "canonical_name": "long-chain fatty acid omega-hydroxylase activity"}
{"concept_id": "C2243890", "aliases": [], "types": ["T044"], "canonical_name": "lauric acid omega-hydroxylase activity"}
{"concept_id": "C2243891", "aliases": [], "types": ["T044"], "canonical_name": "omega-hydroxylase activity"}
{"concept_id": "C2243908", "aliases": [], "types": ["T044"], "canonical_name": "transhydroxylase activity"}
{"concept_id": "C2243919", "aliases": [], "types": ["T044"], "canonical_name": "dibenzothiophene desulfurization enzyme B"}
{"concept_id": "C2243971", "aliases": [], "types": ["T044"], "canonical_name": "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity"}
{"concept_id": "C2243973", "aliases": [], "types": ["T044"], "canonical_name": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity"}
{"concept_id": "C2243999", "aliases": [], "types": ["T044"], "canonical_name": "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)"}
{"concept_id": "C2244014", "aliases": [], "types": ["T044"], "canonical_name": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]"}
{"concept_id": "C2244043", "aliases": ["aryl-aldehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "aryl-aldehyde dehydrogenase (NAD) activity", "definition": "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+. [EC:1.2.1.29]"}
{"concept_id": "C2244057", "aliases": [], "types": ["T044"], "canonical_name": "multifunctional deoxynucleoside kinase activity"}
{"concept_id": "C2244058", "aliases": [], "types": ["T044"], "canonical_name": "multispecific deoxynucleoside kinase activity"}
{"concept_id": "C2244059", "aliases": [], "types": ["T044"], "canonical_name": "multisubstrate deoxyribonucleoside kinase activity"}
{"concept_id": "C2244065", "aliases": [], "types": ["T044"], "canonical_name": "inositol 1-kinase activity"}
{"concept_id": "C2244067", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol 1-kinase activity"}
{"concept_id": "C2244068", "aliases": [], "types": ["T044"], "canonical_name": "myoinositol kinase activity"}
{"concept_id": "C2244070", "aliases": ["2-ketopantoyl lactone reductase activity"], "types": ["T044"], "canonical_name": "2-ketopantoyl lactone reductase activity"}
{"concept_id": "C2244071", "aliases": ["ketopantoyl lactone reductase activity"], "types": ["T044"], "canonical_name": "ketopantoyl lactone reductase activity"}
{"concept_id": "C2244114", "aliases": [], "types": ["T044"], "canonical_name": "protein-disulfide interchange enzyme"}
{"concept_id": "C2244151", "aliases": ["thiamin kinase activity", "ATP:thiamin phosphotransferase activity", "thiamin phosphokinase activity", "thiamin kinase (phosphorylating)", "ATP:thiamine phosphotransferase activity"], "types": ["T044"], "canonical_name": "thiamine kinase activity", "definition": "Catalysis of the reaction: ATP + thiamine = ADP + 2 H(+) + thiamine phosphate. [EC:2.7.1.89, RHEA:12012]"}
{"concept_id": "C2244170", "aliases": [], "types": ["T043"], "canonical_name": "neuronal action potential", "definition": "An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb]"}
{"concept_id": "C2244171", "aliases": ["L-methionine anabolism from L-homoserine via cystathionine", "methionine biosynthetic process from L-homoserine via cystathionine", "L-methionine formation from L-homoserine via cystathionine", "L-methionine synthesis from L-homoserine via cystathionine"], "types": ["T044"], "canonical_name": "L-methionine biosynthetic process from L-homoserine via cystathionine", "definition": "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine. [GOC:go_curators]"}
{"concept_id": "C2244172", "aliases": ["L-methionine synthesis from O-phospho-L-homoserine and cystathionine", "methionine biosynthetic process from O-phospho-L-homoserine and cystathionine", "L-methionine anabolism from O-phospho-L-homoserine and cystathionine", "L-methionine formation from O-phospho-L-homoserine and cystathionine"], "types": ["T044"], "canonical_name": "L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine", "definition": "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine. [GOC:go_curators]"}
{"concept_id": "C2244179", "aliases": ["cysteine anabolism via cystathionine", "cysteine formation via cystathionine", "cysteine synthesis via cystathionine"], "types": ["T044"], "canonical_name": "cysteine biosynthetic process via cystathionine", "definition": "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine. [GOC:go_curators]"}
{"concept_id": "C2244213", "aliases": [], "types": ["T044"], "canonical_name": "beta-alanine transmembrane transporter activity", "definition": "Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid. [GOC:hjd]"}
{"concept_id": "C2244218", "aliases": [], "types": ["T044"], "canonical_name": "ferric-vibriobactin transmembrane transporter activity", "definition": "Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C2244219", "aliases": ["sucrose catabolic process to D-glucose", "sucrose degradation, using glucoside 3-dehydrogenase", "sucrose catabolism, using glucoside 3-dehydrogenase", "sucrose catabolic process, using glucoside 3-dehydrogenase", "sucrose breakdown, using glucoside 3-dehydrogenase"], "types": ["T044"], "canonical_name": "sucrose catabolic process via 3'-ketosucrose", "definition": "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3'-ketosucrose. 3'-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose is then be converted to glucose. [GOC:bf, GOC:dgf, MetaCyc:SUCROSEUTIL2-PWY]"}
{"concept_id": "C2244221", "aliases": [], "types": ["T044"], "canonical_name": "anaerobic electron transport chain", "definition": "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient. [GOC:ai, GOC:mtg_electron_transport]"}
{"concept_id": "C2244222", "aliases": [], "types": ["T044"], "canonical_name": "aerobic electron transport chain", "definition": "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient. [GOC:ai, GOC:mtg_electron_transport]"}
{"concept_id": "C2244223", "aliases": [], "types": ["T043"], "canonical_name": "cellular homeostasis", "definition": "Any process involved in the maintenance of an internal steady state at the level of the cell. [GOC:isa_complete, GOC:jl, ISBN:0395825172]"}
{"concept_id": "C2244227", "aliases": [], "types": ["T044"], "canonical_name": "FAT10 transferase activity", "definition": "Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y --> Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages. [GOC:dph, GOC:mah, PMID:12826404]"}
{"concept_id": "C2244236", "aliases": [], "types": ["T044"], "canonical_name": "prolyl 3-hydroxylase activity"}
{"concept_id": "C2244249", "aliases": [], "types": ["T044"], "canonical_name": "acylase II"}
{"concept_id": "C2244250", "aliases": [], "types": ["T044"], "canonical_name": "aminoacylase II activity"}
{"concept_id": "C2244259", "aliases": ["type I IFN binding"], "types": ["T044"], "canonical_name": "type I interferon binding", "definition": "Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]"}
{"concept_id": "C2244260", "aliases": [], "types": ["T044"], "canonical_name": "interferon-alpha binding"}
{"concept_id": "C2244261", "aliases": [], "types": ["T044"], "canonical_name": "interferon-beta binding"}
{"concept_id": "C2244262", "aliases": [], "types": ["T044"], "canonical_name": "interferon-delta binding"}
{"concept_id": "C2244263", "aliases": [], "types": ["T044"], "canonical_name": "interferon-epsilon binding"}
{"concept_id": "C2244264", "aliases": [], "types": ["T044"], "canonical_name": "interferon-kappa binding"}
{"concept_id": "C2244265", "aliases": [], "types": ["T044"], "canonical_name": "interferon-omega binding"}
{"concept_id": "C2244266", "aliases": [], "types": ["T044"], "canonical_name": "interferon-tau binding"}
{"concept_id": "C2244267", "aliases": [], "types": ["T044"], "canonical_name": "interferon-zeta binding"}
{"concept_id": "C2244278", "aliases": [], "types": ["T043"], "canonical_name": "cerebral cortex radially oriented cell migration", "definition": "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C2244281", "aliases": [], "types": ["T043"], "canonical_name": "initiation of movement involved in cerebral cortex radial glia guided migration", "definition": "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C2244282", "aliases": [], "types": ["T043"], "canonical_name": "initiation of movement involved in cerebral cortex glial-mediated radial migration"}
{"concept_id": "C2244283", "aliases": ["neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "neuronal-glial interaction involved in cerebral cortex radial glia guided migration", "definition": "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C2244284", "aliases": ["cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration", "definition": "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C2244285", "aliases": ["modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration", "definition": "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C2244286", "aliases": [], "types": ["T043"], "canonical_name": "extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration", "definition": "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C2244287", "aliases": ["modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration", "definition": "The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C2244288", "aliases": ["extracellular matrix organisation in marginal zone involved in cerebral cortex radial glia guided migration", "organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration"], "types": ["T043"], "canonical_name": "extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration", "definition": "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C2244290", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell-glial cell adhesion involved in cerebral cortex lamination"}
{"concept_id": "C2244291", "aliases": ["down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration", "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration", "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration", "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration", "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration"], "types": ["T043"], "canonical_name": "negative regulation of cell motility involved in cerebral cortex radial glia guided migration", "definition": "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695]"}
{"concept_id": "C2244292", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration"}
{"concept_id": "C2244294", "aliases": ["negative regulation of hh signaling pathway involved in ventral spinal cord patterning", "downregulation of smoothened signaling pathway in ventral spinal cord patterning", "down-regulation of smoothened signaling pathway in ventral spinal cord patterning", "negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning", "down regulation of smoothened signaling pathway in ventral spinal cord patterning", "negative regulation of smoothened signalling pathway in ventral spinal cord patterning"], "types": ["T044"], "canonical_name": "negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:11262869]"}
{"concept_id": "C2244295", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of smoothened signaling pathway in ventral spinal cord patterning"}
{"concept_id": "C2244296", "aliases": [], "types": ["T043"], "canonical_name": "activation of granule cell precursor proliferation"}
{"concept_id": "C2244297", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of granule cell precursor proliferation"}
{"concept_id": "C2244300", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of granule cell precursor proliferation"}
{"concept_id": "C2244301", "aliases": [], "types": ["T043"], "canonical_name": "calcium-mediated activation of granule cell migration"}
{"concept_id": "C2244302", "aliases": [], "types": ["T043"], "canonical_name": "calcium-mediated stimulation of granule cell migration"}
{"concept_id": "C2244303", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of anterior neural cell fate of the neural plate"}
{"concept_id": "C2244304", "aliases": [], "types": ["T044"], "canonical_name": "Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate"}
{"concept_id": "C2244305", "aliases": [], "types": ["T044"], "canonical_name": "fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate"}
{"concept_id": "C2244308", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell-cell adhesion"}
{"concept_id": "C2244309", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell-cell adhesion"}
{"concept_id": "C2244311", "aliases": ["cellular component disassembly at cellular level", "cellular component disassembly"], "types": ["T043"], "definition": "A cellular process that results in the breakdown of a cellular component. [GOC:isa_complete]", "canonical_name": "cell structure disassembly"}
{"concept_id": "C2244312", "aliases": [], "types": ["T040"], "canonical_name": "ovulation cycle process", "definition": "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. [GOC:isa_complete]"}
{"concept_id": "C2244313", "aliases": [], "types": ["T039"], "canonical_name": "estrous cycle process"}
{"concept_id": "C2244314", "aliases": ["cell structure assembly", "cellular component assembly at cellular level"], "types": ["T043"], "canonical_name": "cellular component assembly", "definition": "The aggregation, arrangement and bonding together of a cellular component. [GOC:isa_complete]"}
{"concept_id": "C2244316", "aliases": ["PAN", "proteasome-activating nucleotidase complex"], "types": ["T026"], "definition": "A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner. [GOC:bf, GOC:mtg_sensu, PMID:19363223, PMID:19481528]", "canonical_name": "proteasome-activating nucleotidase complex location"}
{"concept_id": "C2244317", "aliases": ["proteasome accessory complex location"], "types": ["T026"], "canonical_name": "proteasome accessory complex", "definition": "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. [GOC:mtg_sensu]"}
{"concept_id": "C2244319", "aliases": [], "types": ["T026"], "canonical_name": "eukaryotic ribosomal LSU"}
{"concept_id": "C2244322", "aliases": [], "types": ["T026"], "canonical_name": "eukaryotic ribosomal SSU"}
{"concept_id": "C2244323", "aliases": ["chloroplast ribosomal large subunit complex", "chloroplast ribosomal large subunit complex location", "chloroplast ribosomal LSU complex location", "chloroplast ribosomal LSU complex"], "types": ["T026"], "canonical_name": "chloroplast large ribosomal subunit", "definition": "The large subunit of a ribosome contained within a chloroplast. [GOC:mtg_sensu]"}
{"concept_id": "C2244324", "aliases": ["chloroplast ribosomal SSU complex", "chloroplast ribosomal SSU complex location", "chloroplast ribosomal small subunit complex", "chloroplast ribosomal small subunit complex location"], "types": ["T026"], "canonical_name": "chloroplast small ribosomal subunit", "definition": "The small subunit of a ribosome contained within a chloroplast. [GOC:mtg_sensu]"}
{"concept_id": "C2244325", "aliases": [], "types": ["T044"], "canonical_name": "passive transmembrane transporter activity", "definition": "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244326", "aliases": [], "types": ["T044"], "canonical_name": "mobile ion carrier activity", "definition": "Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]"}
{"concept_id": "C2244327", "aliases": ["porter"], "types": ["T044"], "definition": "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. [GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "membrane potential driven uniporter activity"}
{"concept_id": "C2244328", "aliases": [], "types": ["T044"], "definition": "The passive movement of molecules exceeding the rate expected by simple diffusion. No energy is expended in the process. It is achieved by the introduction of passively diffusing molecules to an enviroment or path that is more favorable to the movement of those molecules. Examples of facilitated diffusion are passive transport of hydrophilic substances across a lipid membrane through hydrophilic pores that traverse the membrane, and the sliding of a DNA BINDING PROTEIN along a strand of DNA.", "canonical_name": "facilitated diffusion"}
{"concept_id": "C2244331", "aliases": [], "types": ["T044"], "canonical_name": "sodium ion uniporter activity", "definition": "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244332", "aliases": [], "types": ["T044"], "canonical_name": "potassium ion uniporter activity", "definition": "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244334", "aliases": [], "types": ["T043"], "canonical_name": "potassium ion antiporter activity", "definition": "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244335", "aliases": [], "types": ["T044"], "canonical_name": "transmitter-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244336", "aliases": [], "types": ["T044"], "canonical_name": "phosphorylation-gated channel activity", "definition": "Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244337", "aliases": ["non-gated, wide pore channel activity"], "types": ["T044"], "canonical_name": "wide pore channel activity", "definition": "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244338", "aliases": [], "types": ["T044"], "canonical_name": "gap junction activity"}
{"concept_id": "C2244339", "aliases": ["ion channels"], "types": ["T044"], "definition": "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus. [GOC:mtg_transport, ISBN:0815340729]", "canonical_name": "narrow pore, gated channel activity"}
{"concept_id": "C2244340", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated channel activity", "definition": "Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244342", "aliases": [], "types": ["T044"], "canonical_name": "ligand-gated channel activity", "definition": "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244343", "aliases": ["extracellular substance gated channel activity", "neurotransmitter-gated channel activity"], "types": ["T044"], "canonical_name": "transmitter-gated channel activity", "definition": "Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244344", "aliases": [], "types": ["T044"], "canonical_name": "gated channel activity", "definition": "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. [GOC:mtg_transport]"}
{"concept_id": "C2244345", "aliases": [], "types": ["T044"], "canonical_name": "substrate-specific channel activity"}
{"concept_id": "C2244346", "aliases": [], "types": ["T044"], "canonical_name": "ion gated channel activity", "definition": "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. [GOC:mtg_transport]"}
{"concept_id": "C2244347", "aliases": [], "types": ["T044"], "canonical_name": "leak channel activity", "definition": "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244348", "aliases": [], "types": ["T044"], "canonical_name": "potassium ion leak channel activity", "definition": "Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244349", "aliases": [], "types": ["T044"], "canonical_name": "narrow pore channel activity", "definition": "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244350", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated cation channel activity", "definition": "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244352", "aliases": [], "types": ["T044"], "canonical_name": "glutamate-gated calcium ion channel activity", "definition": "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244353", "aliases": [], "types": ["T044"], "canonical_name": "serotonin-gated cation channel activity"}
{"concept_id": "C2244354", "aliases": [], "types": ["T044"], "canonical_name": "GABA-gated chloride ion channel activity", "definition": "Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244355", "aliases": [], "types": ["T044"], "canonical_name": "glycine-gated chloride ion channel activity", "definition": "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244358", "aliases": ["glucose PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244359", "aliases": ["sorbitol PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244360", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane transporter activity", "definition": "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:jid, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244361", "aliases": [], "types": ["T044"], "canonical_name": "alanine transmembrane transporter activity", "definition": "Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244362", "aliases": [], "types": ["T044"], "canonical_name": "dephosphorylation-gated channel activity", "definition": "Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244366", "aliases": ["lactose PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244367", "aliases": ["mannose PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244368", "aliases": ["sorbose PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, PMID:10613875, RHEA:49296]"}
{"concept_id": "C2244369", "aliases": ["mannitol PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244370", "aliases": ["maltose PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244371", "aliases": ["cellobiose PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244372", "aliases": ["galactitol PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244373", "aliases": ["galactosamine PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244374", "aliases": ["fructose PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244375", "aliases": ["sucrose PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244376", "aliases": ["trehalose PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244377", "aliases": ["N-acetylglucosamine PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244378", "aliases": ["N-acetylgalactosamine PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244379", "aliases": ["beta-glucoside PTS transporter activity"], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244380", "aliases": [], "types": ["T044"], "canonical_name": "macromolecule transmembrane transporter activity", "definition": "Enables the transfer of a macromolecule from one side of a membrane to the other. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244381", "aliases": [], "types": ["T044"], "canonical_name": "bacteriocin transmembrane transporter activity", "definition": "Enables the transfer of a bacteriocin from one side of a membrane to the other. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244382", "aliases": [], "types": ["T044"], "canonical_name": "channel-forming ionophore activity", "definition": "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244383", "aliases": [], "types": ["T044"], "canonical_name": "serine transmembrane transporter activity", "definition": "Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244384", "aliases": [], "types": ["T044"], "canonical_name": "inorganic cation transmembrane transporter activity", "definition": "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244387", "aliases": [], "types": ["T044"], "canonical_name": "low-affinity tryptophan transmembrane transporter activity", "definition": "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2244388", "aliases": [], "types": ["T044"], "canonical_name": "low-affinity tryptophan permease activity"}
{"concept_id": "C2244389", "aliases": ["IK calcium-activated potassium channel activity", "intermdiate conductance KCa channels", "IK KCa channels"], "types": ["T044"], "canonical_name": "Intermediate conductance calcium-activated potassium channel activity", "definition": "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, OMIM:602754]"}
{"concept_id": "C2244390", "aliases": [], "types": ["T044"], "canonical_name": "proton-dependent peptide secondary active transmembrane transporter activity", "definition": "Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. [GOC:mtg_transport]"}
{"concept_id": "C2244391", "aliases": [], "types": ["T039"], "canonical_name": "regulation of transmembrane transporter activity", "definition": "Any process that modulates the frequency, rate or extent of transmembrane transporter activity. [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport]"}
{"concept_id": "C2244392", "aliases": [], "types": ["T044"], "canonical_name": "electron transport chain", "definition": "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. [GOC:mtg_electron_transport]"}
{"concept_id": "C2244393", "aliases": ["respiratory electron transport chain"], "types": ["T044"], "definition": "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. [GOC:mtg_electron_transport, ISBN:0716720094]", "canonical_name": "electron transfer"}
{"concept_id": "C2244394", "aliases": ["nucleus migration to megagametophyte poles", "nucleus migration to female gametophyte poles", "nucleus migration to embryo sac poles", "nuclear migration to female gametophyte poles", "nuclear migration to megagametophyte poles"], "types": ["T043"], "canonical_name": "nuclear migration to embryo sac poles", "definition": "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell. [GOC:jid, GOC:mtg_plant, ISBN:047186840X]"}
{"concept_id": "C2244395", "aliases": ["nucleus migration to the female gametophyte centre", "nuclear migration to the megagametophyte centre", "nucleus migration to the female gametophyte center", "nuclear migration to the female gametophyte centre", "nuclear migration to the female gametophyte center", "nuclear migration to the megagametophyte center", "nuclear migration to the embryo sac centre"], "types": ["T043"], "canonical_name": "nuclear migration to the embryo sac center", "definition": "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell. [GOC:jid, GOC:mtg_plant, ISBN:047186840X]"}
{"concept_id": "C2244396", "aliases": [], "types": ["T043"], "canonical_name": "cellular anion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of anions at the level of a cell. [GOC:ceb, GOC:mah]"}
{"concept_id": "C2244397", "aliases": [], "types": ["T043"], "canonical_name": "cellular potassium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. [GOC:mah]"}
{"concept_id": "C2244411", "aliases": [], "types": ["T043"], "canonical_name": "cellular manganese ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell. [GOC:mah]"}
{"concept_id": "C2244416", "aliases": ["primary-amine dehydrogenase activity"], "types": ["T044"], "canonical_name": "primary-amine dehydrogenase"}
{"concept_id": "C2244433", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast photosystem I", "definition": "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C2244435", "aliases": ["AP-type membrane coat adaptor complex location"], "types": ["T026"], "canonical_name": "AP-type membrane coat adaptor complex", "definition": "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). [GOC:mah, PMID:10611976, PMID:15473838]"}
{"concept_id": "C2244438", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylglucosaminyltransferase V activity"}
{"concept_id": "C2244451", "aliases": [], "types": ["T043"], "canonical_name": "activation of frizzled signaling pathway"}
{"concept_id": "C2244452", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt receptor signaling pathway"}
{"concept_id": "C2244453", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of frizzled signaling pathway"}
{"concept_id": "C2244454", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of Wnt receptor signaling pathway"}
{"concept_id": "C2244459", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of frizzled signaling pathway"}
{"concept_id": "C2244460", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt receptor signaling pathway"}
{"concept_id": "C2244461", "aliases": [], "types": ["T040"], "canonical_name": "activation of blood coagulation"}
{"concept_id": "C2244462", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of blood coagulation"}
{"concept_id": "C2244465", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of blood coagulation"}
{"concept_id": "C2244470", "aliases": ["quinate:NAD 5-oxidoreductase activity", "quinate:NAD(+) 5-oxidoreductase activity", "quinate:NAD(+) 3-oxidoreductase activity", "quinate:NAD 3-oxidoreductase activity"], "types": ["T044"], "canonical_name": "quinate 3-dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+. [EC:1.1.1.24]"}
{"concept_id": "C2244471", "aliases": ["quinic dehydrogenase activity"], "types": ["T044"], "canonical_name": "quinic dehydrogenase activity"}
{"concept_id": "C2244473", "aliases": ["glycolate:NADP+ oxidoreductase activity", "glyoxylate reductase (NADP+)", "glyoxylate reductase (NADP+) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. [RHEA:10992]", "canonical_name": "NADPH-glyoxylate reductase activity"}
{"concept_id": "C2244492", "aliases": [], "types": ["T044"], "canonical_name": "5-formyltetrahydrofolate cyclodehydrase"}
{"concept_id": "C2244497", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of ossification"}
{"concept_id": "C2244501", "aliases": ["cell wall-enclosed periplasmic space", "cell wall bounded periplasmic space", "IWZ"], "types": ["T026"], "canonical_name": "cell wall-bounded periplasmic space", "definition": "The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria. [GOC:mlg, GOC:mtg_sensu]"}
{"concept_id": "C2244505", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell growth"}
{"concept_id": "C2244506", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell growth"}
{"concept_id": "C2244509", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell growth"}
{"concept_id": "C2244511", "aliases": [], "types": ["T043"], "canonical_name": "cellular monovalent inorganic anion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C2244512", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell migration"}
{"concept_id": "C2244513", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell migration"}
{"concept_id": "C2244526", "aliases": [], "types": ["T044"], "canonical_name": "hyaluronidase [but cf. EC:3.2.1.35 (hyalurononglucosaminidase) and EC:3.2.1.36 (hyaluronoglucuronidase)]"}
{"concept_id": "C2244527", "aliases": ["hyaluronidase activity"], "types": ["T044"], "canonical_name": "hyaluronidase activity"}
{"concept_id": "C2244529", "aliases": [], "types": ["T044"], "canonical_name": "spreading factor activity"}
{"concept_id": "C2244533", "aliases": [], "types": ["T044"], "canonical_name": "chondroitinase AC"}
{"concept_id": "C2244551", "aliases": ["mitotic sporulation", "asexual spore formation", "mitotic spore formation", "asexual reproductive sporulation"], "types": ["T043"], "canonical_name": "asexual sporulation", "definition": "The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi. [GOC:mah, PMID:9529886]"}
{"concept_id": "C2244553", "aliases": ["SSU-rRNA maturation"], "types": ["T045"], "canonical_name": "maturation of SSU-rRNA", "definition": "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. [GOC:curators]"}
{"concept_id": "C2244554", "aliases": [], "types": ["T042"], "canonical_name": "activation of bone mineralization"}
{"concept_id": "C2244555", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of bone mineralization"}
{"concept_id": "C2244558", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of bone mineralization"}
{"concept_id": "C2244559", "aliases": [], "types": ["T040"], "canonical_name": "activation of transforming growth factor beta receptor signaling pathway"}
{"concept_id": "C2244560", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of transforming growth factor beta receptor signaling pathway"}
{"concept_id": "C2244563", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of transforming growth factor beta receptor signaling pathway"}
{"concept_id": "C2244564", "aliases": [], "types": ["T043"], "canonical_name": "activation of BMP signaling pathway"}
{"concept_id": "C2244565", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of BMP signaling pathway"}
{"concept_id": "C2244568", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of BMP signaling pathway"}
{"concept_id": "C2244570", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axon extension"}
{"concept_id": "C2244580", "aliases": [], "types": ["T044"], "canonical_name": "pectic lyase activity"}
{"concept_id": "C2244581", "aliases": ["pectin trans-eliminase activity"], "types": ["T044"], "canonical_name": "pectin trans-eliminase activity"}
{"concept_id": "C2244588", "aliases": [], "types": ["T044"], "canonical_name": "cholate catabolic process"}
{"concept_id": "C2244592", "aliases": [], "types": ["T044"], "canonical_name": "PEPCTrP"}
{"concept_id": "C2244597", "aliases": ["phosphoenolpyruvic carboxykinase"], "types": ["T044"], "canonical_name": "phosphoenolpyruvic carboxykinase"}
{"concept_id": "C2244601", "aliases": ["phosphopyruvate carboxykinase"], "types": ["T044"], "canonical_name": "phosphopyruvate carboxykinase"}
{"concept_id": "C2244606", "aliases": [], "types": ["T044"], "canonical_name": "alpha-L-rhamnosidase N"}
{"concept_id": "C2244607", "aliases": [], "types": ["T044"], "canonical_name": "alpha-L-rhamnosidase T"}
{"concept_id": "C2244609", "aliases": [], "types": ["T045"], "canonical_name": "gelonin"}
{"concept_id": "C2244610", "aliases": [], "types": ["T045"], "canonical_name": "mirabilis antiviral protein"}
{"concept_id": "C2244611", "aliases": [], "types": ["T045"], "canonical_name": "momorcochin-S"}
{"concept_id": "C2244612", "aliases": [], "types": ["T045"], "canonical_name": "nigrin b"}
{"concept_id": "C2244616", "aliases": [], "types": ["T045"], "canonical_name": "saporins"}
{"concept_id": "C2244625", "aliases": [], "types": ["T044"], "canonical_name": "hemicellulase accessory"}
{"concept_id": "C2244639", "aliases": [], "types": ["T043"], "canonical_name": "cellular sulfate ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell. [GOC:mah]"}
{"concept_id": "C2244641", "aliases": ["ADP-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "ADP-ribosyltransferase activity"}
{"concept_id": "C2244645", "aliases": [], "types": ["T040"], "canonical_name": "activation of border follicle cell delamination"}
{"concept_id": "C2244646", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of border follicle cell delamination"}
{"concept_id": "C2244649", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of border follicle cell delamination"}
{"concept_id": "C2244650", "aliases": [], "types": ["T043"], "canonical_name": "oocyte localization during germarium-derived egg chamber formation"}
{"concept_id": "C2244666", "aliases": ["fatty acid methyltransferase activity", "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity", "fatty-acid O-methyltransferase activity"], "types": ["T044"], "canonical_name": "fatty acid O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester. [EC:2.1.1.15]"}
{"concept_id": "C2244680", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol 1-methyltransferase activity"}
{"concept_id": "C2244682", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol 1-O-methyltransferase activity"}
{"concept_id": "C2244687", "aliases": [], "types": ["T044"], "canonical_name": "inositol 3-O-methyltransferase activity"}
{"concept_id": "C2244689", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol 3-O-methyltransferase activity"}
{"concept_id": "C2244692", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosylmethionine:myo-inositol 3-methyltransferase activity"}
{"concept_id": "C2244694", "aliases": [], "types": ["T045"], "canonical_name": "RNA-pentose methylase activity"}
{"concept_id": "C2244697", "aliases": [], "types": ["T045"], "canonical_name": "thiostrepton-resistance methylase activity"}
{"concept_id": "C2244706", "aliases": ["histidine-alpha-N-methyltransferase activity"], "types": ["T044"], "canonical_name": "histidine-alpha-N-methyltransferase activity"}
{"concept_id": "C2244718", "aliases": [], "types": ["T044"], "canonical_name": "arylamine N-methyltransferase activity"}
{"concept_id": "C2244719", "aliases": [], "types": ["T044"], "canonical_name": "nicotine N-methyltransferase activity"}
{"concept_id": "C2244721", "aliases": [], "types": ["T044"], "canonical_name": "tryptamine methyltransferase"}
{"concept_id": "C2244722", "aliases": [], "types": ["T044"], "canonical_name": "tryptamine N-methyltransferase activity"}
{"concept_id": "C2244744", "aliases": [], "types": ["T044"], "canonical_name": "flavonoid O-methyltransferase activity"}
{"concept_id": "C2244747", "aliases": [], "types": ["T044"], "canonical_name": "flavonol 3-O-methyltransferase activity"}
{"concept_id": "C2244752", "aliases": [], "types": ["T044"], "canonical_name": "7-OMT activity"}
{"concept_id": "C2244753", "aliases": [], "types": ["T044"], "canonical_name": "flavonol 7-methyltransferase activity"}
{"concept_id": "C2244754", "aliases": [], "types": ["T044"], "canonical_name": "flavonol 7-O-methyltransferase activity"}
{"concept_id": "C2244757", "aliases": [], "types": ["T044"], "canonical_name": "4'-OMT activity"}
{"concept_id": "C2244758", "aliases": [], "types": ["T044"], "canonical_name": "flavonol 4'-methyltransferase activity"}
{"concept_id": "C2244759", "aliases": [], "types": ["T044"], "canonical_name": "flavonol 4'-O-methyltransferase activity"}
{"concept_id": "C2244762", "aliases": [], "types": ["T044"], "canonical_name": "flavonol 6-O-methyltransferase activity"}
{"concept_id": "C2244768", "aliases": [], "types": ["T044"], "canonical_name": "flavonol 8-O-methyltransferase activity"}
{"concept_id": "C2244794", "aliases": ["benzoyl-CoA:anthranilate N-benzoyltransferase"], "types": ["T044"], "canonical_name": "benzoyl-CoA:anthranilate N-benzoyltransferase"}
{"concept_id": "C2244826", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol 6-O-methyltransferase activity"}
{"concept_id": "C2244834", "aliases": [], "types": ["T044"], "canonical_name": "halogenated phenol O-methyltransferase activity"}
{"concept_id": "C2244847", "aliases": [], "types": ["T044"], "canonical_name": "sterol C-methyltransferase activity"}
{"concept_id": "C2244851", "aliases": [], "types": ["T044"], "canonical_name": "SMT(2) activity"}
{"concept_id": "C2244869", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nucleotide biosynthetic process"}
{"concept_id": "C2244870", "aliases": [], "types": ["T040"], "canonical_name": "activation of nucleotide biosynthetic process"}
{"concept_id": "C2244871", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of nucleotide biosynthetic process"}
{"concept_id": "C2244874", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of nucleotide catabolic process"}
{"concept_id": "C2244875", "aliases": [], "types": ["T045"], "canonical_name": "activation of nucleotide catabolic process"}
{"concept_id": "C2244876", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of nucleotide catabolic process"}
{"concept_id": "C2244909", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of actin filament depolymerization"}
{"concept_id": "C2244910", "aliases": [], "types": ["T043"], "canonical_name": "activation of actin filament depolymerization"}
{"concept_id": "C2244911", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of actin filament depolymerization"}
{"concept_id": "C2244914", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of actin filament polymerization"}
{"concept_id": "C2244915", "aliases": [], "types": ["T043"], "canonical_name": "activation of actin filament polymerization"}
{"concept_id": "C2244916", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of actin filament polymerization"}
{"concept_id": "C2244919", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intermediate filament polymerization"}
{"concept_id": "C2244920", "aliases": [], "types": ["T043"], "canonical_name": "activation of intermediate filament polymerization"}
{"concept_id": "C2244921", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of intermediate filament polymerization"}
{"concept_id": "C2244924", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intermediate filament depolymerization"}
{"concept_id": "C2244925", "aliases": [], "types": ["T043"], "canonical_name": "activation of intermediate filament depolymerization"}
{"concept_id": "C2244926", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of intermediate filament depolymerization"}
{"concept_id": "C2244928", "aliases": [], "types": ["T045"], "canonical_name": "termination of RNA polymerase II transcription, poly(A)-coupled", "definition": "The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination. [GOC:txnOH, PMID:12944462, PMID:18679429]"}
{"concept_id": "C2244929", "aliases": ["transcription termination from Pol II promoter, poly(A)-independent", "transcription termination from Pol II promoter, RNA polymerase(A)-independent", "termination of RNA polymerase II transcription, poly(A)-independent"], "types": ["T045"], "canonical_name": "termination of RNA polymerase II transcription, exosome-dependent", "definition": "The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end. [GOC:txnOH, PMID:12944462, PMID:18679429]"}
{"concept_id": "C2244930", "aliases": ["3-hydroxyaspartate dehydratase activity"], "types": ["T044"], "canonical_name": "3-hydroxyaspartate dehydratase activity"}
{"concept_id": "C2244936", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of granulocyte differentiation"}
{"concept_id": "C2244937", "aliases": [], "types": ["T043"], "canonical_name": "activation of granulocyte differentiation"}
{"concept_id": "C2244938", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of granulocyte differentiation"}
{"concept_id": "C2244941", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of epithelial cell differentiation"}
{"concept_id": "C2244942", "aliases": [], "types": ["T043"], "canonical_name": "activation of epithelial cell differentiation"}
{"concept_id": "C2244943", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of epithelial cell differentiation"}
{"concept_id": "C2244946", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of polarized epithelial cell differentiation"}
{"concept_id": "C2244947", "aliases": [], "types": ["T043"], "canonical_name": "activation of polarized epithelial cell differentiation"}
{"concept_id": "C2244948", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of polarized epithelial cell differentiation"}
{"concept_id": "C2244951", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myeloid dendritic cell activation"}
{"concept_id": "C2244952", "aliases": [], "types": ["T043"], "canonical_name": "activation of myeloid dendritic cell activation"}
{"concept_id": "C2244953", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of myeloid dendritic cell activation"}
{"concept_id": "C2244956", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of B cell proliferation"}
{"concept_id": "C2244957", "aliases": [], "types": ["T043"], "canonical_name": "activation of B cell proliferation"}
{"concept_id": "C2244958", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of B cell proliferation"}
{"concept_id": "C2244960", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of type IIa hypersensitivity"}
{"concept_id": "C2244961", "aliases": [], "types": ["T040"], "canonical_name": "activation of type IIa hypersensitivity"}
{"concept_id": "C2244962", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of type IIa hypersensitivity"}
{"concept_id": "C2244965", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of type IIb hypersensitivity"}
{"concept_id": "C2244966", "aliases": [], "types": ["T040"], "canonical_name": "activation of type IIb hypersensitivity"}
{"concept_id": "C2244967", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of type IIb hypersensitivity"}
{"concept_id": "C2244970", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of type III hypersensitivity"}
{"concept_id": "C2244971", "aliases": [], "types": ["T040"], "canonical_name": "activation of type III hypersensitivity"}
{"concept_id": "C2244972", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of type III hypersensitivity"}
{"concept_id": "C2244975", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of type IV hypersensitivity"}
{"concept_id": "C2244976", "aliases": [], "types": ["T040"], "canonical_name": "activation of type IV hypersensitivity"}
{"concept_id": "C2244977", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of type IV hypersensitivity"}
{"concept_id": "C2244980", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of type I hypersensitivity"}
{"concept_id": "C2244981", "aliases": [], "types": ["T040"], "canonical_name": "activation of type I hypersensitivity"}
{"concept_id": "C2244982", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of type I hypersensitivity"}
{"concept_id": "C2244985", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of antibody-dependent cellular cytotoxicity"}
{"concept_id": "C2244986", "aliases": [], "types": ["T043"], "canonical_name": "activation of antibody-dependent cellular cytotoxicity"}
{"concept_id": "C2244987", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of antibody-dependent cellular cytotoxicity"}
{"concept_id": "C2244990", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of cytokine production"}
{"concept_id": "C2244991", "aliases": [], "types": ["T040"], "canonical_name": "activation of cytokine production"}
{"concept_id": "C2244992", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of cytokine production"}
{"concept_id": "C2244995", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of complement activation, lectin pathway"}
{"concept_id": "C2244996", "aliases": [], "types": ["T043"], "canonical_name": "activation of complement activation, lectin pathway"}
{"concept_id": "C2244997", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of complement activation, lectin pathway"}
{"concept_id": "C2245003", "aliases": [], "types": ["T042"], "canonical_name": "retina homeostasis", "definition": "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178]"}
{"concept_id": "C2245004", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of cytolysis of host cells"}
{"concept_id": "C2245005", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of cytolysis of host cells"}
{"concept_id": "C2245006", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of cytolysis of host cells"}
{"concept_id": "C2245008", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of leukocyte mediated cytotoxicity"}
{"concept_id": "C2245009", "aliases": [], "types": ["T043"], "canonical_name": "activation of leukocyte mediated cytotoxicity"}
{"concept_id": "C2245010", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of leukocyte mediated cytotoxicity"}
{"concept_id": "C2245013", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of vascular endothelial growth factor receptor signaling pathway"}
{"concept_id": "C2245014", "aliases": [], "types": ["T044"], "canonical_name": "activation of vascular endothelial growth factor receptor signaling pathway"}
{"concept_id": "C2245015", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of vascular endothelial growth factor receptor signaling pathway"}
{"concept_id": "C2245017", "aliases": ["NADH dehydrogenase complex", "NADH dehydrogenase complex location"], "types": ["T026"], "definition": "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. [GOC:mah]", "canonical_name": "Complex I"}
{"concept_id": "C2245021", "aliases": ["upregulation of sterol regulatory element binding protein target gene transcription", "endoplasmic reticulum to nucleus sterol response pathway", "positive regulation of transcription via sterol regulatory element binding", "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response", "SREBP signalling", "ER-nuclear sterol response pathway", "sterol depletion response, SREBP target gene transcriptional activation", "sterol response element binding protein signaling pathway", "SREBP-mediated signaling pathway", "positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway", "positive regulation of sterol regulatory element binding protein target gene transcription", "endoplasmic reticulum-nuclear sterol response pathway", "up-regulation of sterol regulatory element binding protein target gene transcription", "SREBP-mediated signalling pathway", "SREBP target gene transcriptional activation", "ER to nucleus sterol response pathway", "up regulation of sterol regulatory element binding protein target gene transcription"], "types": ["T045"], "canonical_name": "SREBP signaling pathway", "definition": "The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription. [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871]"}
{"concept_id": "C2245022", "aliases": ["down-regulation of septation initiation signaling", "down regulation of septation initiation signaling", "negative regulation of septation initiation signaling cascade", "negative regulation of septation initiation signalling", "downregulation of septation initiation signaling", "negative regulation of septation initiation network"], "types": ["T044"], "canonical_name": "negative regulation of septation initiation signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling. [GOC:mah]"}
{"concept_id": "C2245023", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of septation initiation signaling"}
{"concept_id": "C2245024", "aliases": [], "types": ["T040"], "canonical_name": "activation of septation initiation signaling"}
{"concept_id": "C2245025", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of septation initiation signaling"}
{"concept_id": "C2245026", "aliases": ["upregulation of septation initiation signaling", "positive regulation of septation initiation signalling", "up-regulation of septation initiation signaling", "positive regulation of septation initiation signaling cascade", "up regulation of septation initiation signaling", "positive regulation of septation initiation network"], "types": ["T044"], "canonical_name": "positive regulation of septation initiation signaling", "definition": "Any process that activates or increases the frequency, rate or extent of septation initiation signaling. [GOC:mah]"}
{"concept_id": "C2245028", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of histone modification"}
{"concept_id": "C2245029", "aliases": [], "types": ["T040"], "canonical_name": "activation of histone modification"}
{"concept_id": "C2245030", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of histone modification"}
{"concept_id": "C2245033", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of histone methylation"}
{"concept_id": "C2245034", "aliases": [], "types": ["T040"], "canonical_name": "activation of histone methylation"}
{"concept_id": "C2245035", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of histone methylation"}
{"concept_id": "C2245038", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of histone deacetylation"}
{"concept_id": "C2245039", "aliases": [], "types": ["T040"], "canonical_name": "activation of histone deacetylation"}
{"concept_id": "C2245040", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of histone deacetylation"}
{"concept_id": "C2245043", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of histone deacetylation at centromere"}
{"concept_id": "C2245044", "aliases": [], "types": ["T040"], "canonical_name": "activation of histone deacetylation at centromere"}
{"concept_id": "C2245045", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of histone deacetylation at centromere"}
{"concept_id": "C2245064", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microtubule polymerization or depolymerization"}
{"concept_id": "C2245065", "aliases": [], "types": ["T043"], "canonical_name": "activation of microtubule polymerization or depolymerization"}
{"concept_id": "C2245066", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of microtubule polymerization or depolymerization"}
{"concept_id": "C2245069", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microtubule polymerization"}
{"concept_id": "C2245070", "aliases": [], "types": ["T043"], "canonical_name": "activation of microtubule polymerization"}
{"concept_id": "C2245071", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of microtubule polymerization"}
{"concept_id": "C2245073", "aliases": [], "types": ["T043"], "canonical_name": "activation of microtubule depolymerization"}
{"concept_id": "C2245074", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of microtubule depolymerization"}
{"concept_id": "C2245076", "aliases": ["L-serine:NADP+ 3-oxidoreductase activity"], "types": ["T043"], "canonical_name": "serine 3-dehydrogenase activity", "definition": "Catalysis of the reaction: L-serine + NADP(+) = L-alpha-formylglycine + 2 H(+) + NADPH. [EC:1.1.1.276, RHEA:21596]"}
{"concept_id": "C2245083", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of conjugation with cellular fusion"}
{"concept_id": "C2245084", "aliases": [], "types": ["T043"], "canonical_name": "activation of conjugation with cellular fusion"}
{"concept_id": "C2245085", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of conjugation with cellular fusion"}
{"concept_id": "C2245087", "aliases": [], "types": ["T042"], "canonical_name": "migratory slug development during sorocarp development"}
{"concept_id": "C2245088", "aliases": [], "types": ["T042"], "canonical_name": "standing slug development during sorocarp development"}
{"concept_id": "C2245089", "aliases": [], "types": ["T039"], "canonical_name": "regulation of aggregate size involved in sorocarp development", "definition": "Any process that modulates the size of the aggregate formed during sorocarp formation. [GOC:mah, GOC:mtg_sensu, GOC:pg, PMID:4338436]"}
{"concept_id": "C2245090", "aliases": ["downregulation of aggregate size", "down regulation of aggregate size", "down-regulation of aggregate size"], "types": ["T039"], "canonical_name": "negative regulation of aggregate size involved in sorocarp development", "definition": "Any process that decreases the size of the aggregate formed during sorocarp formation. [GOC:mah, GOC:mtg_sensu, GOC:pg, PMID:5002049]"}
{"concept_id": "C2245091", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of aggregate size"}
{"concept_id": "C2245092", "aliases": ["upregulation of aggregate size", "up regulation of aggregate size", "up-regulation of aggregate size"], "types": ["T039"], "canonical_name": "positive regulation of aggregate size involved in sorocarp development", "definition": "Any process that increases the size of the aggregate formed during sorocarp formation. [GOC:mah, GOC:pg, PMID:5002049]"}
{"concept_id": "C2245093", "aliases": [], "types": ["T039"], "canonical_name": "activation of aggregate size"}
{"concept_id": "C2245094", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of aggregate size"}
{"concept_id": "C2245095", "aliases": ["otoconia mineralization", "otoconium mineralization"], "types": ["T042"], "canonical_name": "otolith mineralization completed early in development", "definition": "The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear. [GOC:dsf, PMID:15581873]"}
{"concept_id": "C2245104", "aliases": ["xylanase"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues. [GOC:jh2, ISBN:81-7736-269-0]", "canonical_name": "xylanase activity"}
{"concept_id": "C2245107", "aliases": [], "types": ["T044"], "canonical_name": "1,4-beta-D-glucan glucohydrolase activity"}
{"concept_id": "C2245108", "aliases": [], "types": ["T044"], "canonical_name": "beta-1,4-beta-glucanase activity"}
{"concept_id": "C2245116", "aliases": ["external leaflet of cell outer membrane"], "types": ["T026"], "canonical_name": "external side of cell outer membrane", "definition": "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell. [GOC:mlg, GOC:mtg_sensu]"}
{"concept_id": "C2245129", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of cyclase activity"}
{"concept_id": "C2245130", "aliases": [], "types": ["T044"], "canonical_name": "activation of cyclase activity"}
{"concept_id": "C2245131", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of cyclase activity"}
{"concept_id": "C2245134", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of guanylate cyclase activity"}
{"concept_id": "C2245135", "aliases": [], "types": ["T044"], "canonical_name": "activation of guanylate cyclase activity"}
{"concept_id": "C2245136", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of guanylate cyclase activity"}
{"concept_id": "C2245138", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of stalk cell differentiation"}
{"concept_id": "C2245139", "aliases": [], "types": ["T043"], "canonical_name": "activation of stalk cell differentiation"}
{"concept_id": "C2245140", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of stalk cell differentiation"}
{"concept_id": "C2245142", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cellular metabolic process"}
{"concept_id": "C2245143", "aliases": [], "types": ["T044"], "canonical_name": "activation of cellular metabolic process"}
{"concept_id": "C2245144", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of cellular metabolic process"}
{"concept_id": "C2245147", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of cellular biosynthetic process"}
{"concept_id": "C2245148", "aliases": [], "types": ["T040"], "canonical_name": "activation of cellular biosynthetic process"}
{"concept_id": "C2245149", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of cellular biosynthetic process"}
{"concept_id": "C2245152", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of cellular catabolic process"}
{"concept_id": "C2245153", "aliases": [], "types": ["T040"], "canonical_name": "activation of cellular catabolic process"}
{"concept_id": "C2245154", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of cellular catabolic process"}
{"concept_id": "C2245157", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein complex assembly"}
{"concept_id": "C2245158", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein complex assembly"}
{"concept_id": "C2245159", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein complex assembly"}
{"concept_id": "C2245162", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sulfur amino acid metabolic process"}
{"concept_id": "C2245163", "aliases": [], "types": ["T043"], "canonical_name": "activation of sulfur amino acid metabolic process"}
{"concept_id": "C2245164", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of sulfur amino acid metabolic process"}
{"concept_id": "C2245167", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vesicle fusion"}
{"concept_id": "C2245168", "aliases": [], "types": ["T043"], "canonical_name": "activation of vesicle fusion"}
{"concept_id": "C2245169", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of vesicle fusion"}
{"concept_id": "C2245172", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell killing"}
{"concept_id": "C2245173", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell killing"}
{"concept_id": "C2245174", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell killing"}
{"concept_id": "C2245182", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of defense response"}
{"concept_id": "C2245183", "aliases": [], "types": ["T040"], "canonical_name": "activation of defense response"}
{"concept_id": "C2245184", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of defense response"}
{"concept_id": "C2245191", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of prostaglandin biosynthetic process"}
{"concept_id": "C2245192", "aliases": [], "types": ["T044"], "canonical_name": "activation of prostaglandin biosynthetic process"}
{"concept_id": "C2245193", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of prostaglandin biosynthetic process"}
{"concept_id": "C2245196", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein ubiquitination"}
{"concept_id": "C2245197", "aliases": [], "types": ["T040"], "canonical_name": "activation of protein ubiquitination"}
{"concept_id": "C2245198", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of protein ubiquitination"}
{"concept_id": "C2245200", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein modification process", "definition": "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. [GOC:mah, GOC:tb]"}
{"concept_id": "C2245201", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of protein modification"}
{"concept_id": "C2245202", "aliases": [], "types": ["T040"], "canonical_name": "activation of protein modification"}
{"concept_id": "C2245203", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of protein modification"}
{"concept_id": "C2245205", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mRNA cleavage"}
{"concept_id": "C2245206", "aliases": [], "types": ["T045"], "canonical_name": "activation of mRNA cleavage"}
{"concept_id": "C2245207", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of mRNA cleavage"}
{"concept_id": "C2245210", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mRNA 3'-end processing"}
{"concept_id": "C2245211", "aliases": [], "types": ["T045"], "canonical_name": "activation of mRNA 3'-end processing"}
{"concept_id": "C2245212", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of mRNA 3'-end processing"}
{"concept_id": "C2245214", "aliases": ["fast-twitch skeletal fibre contraction", "fast-twitch skeletal fiber contraction", "fast-twitch skeletal myofibre contraction", "fast-twitch skeletal muscle fibre contraction", "fast-twitch skeletal myofiber contraction"], "types": ["T039"], "canonical_name": "fast-twitch skeletal muscle fiber contraction", "definition": "A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability. [GOC:ef, GOC:mah, GOC:mtg_muscle]"}
{"concept_id": "C2245215", "aliases": ["slow-twitch skeletal muscle fibre contraction"], "types": ["T039"], "canonical_name": "slow-twitch skeletal muscle fiber contraction", "definition": "A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue. [GOC:ef, GOC:mah, GOC:mtg_muscle]"}
{"concept_id": "C2245216", "aliases": ["regulation of heterochromatin formation"], "types": ["T043"], "canonical_name": "regulation of heterochromatin assembly", "definition": "Any process that modulates the frequency, rate, extent or location of heterochromatin formation. [GOC:mah]"}
{"concept_id": "C2245217", "aliases": ["regulation of fast-twitch skeletal muscle contraction"], "types": ["T040"], "canonical_name": "regulation of fast-twitch skeletal muscle fiber contraction", "definition": "Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction. [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2245218", "aliases": ["down-regulation of fast-twitch skeletal muscle contraction", "down regulation of fast-twitch skeletal muscle contraction", "negative regulation of fast-twitch skeletal muscle contraction", "downregulation of fast-twitch skeletal muscle contraction"], "types": ["T040"], "canonical_name": "negative regulation of fast-twitch skeletal muscle fiber contraction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction. [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2245219", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of fast-twitch skeletal muscle contraction"}
{"concept_id": "C2245220", "aliases": ["up regulation of fast-twitch skeletal muscle contraction", "upregulation of fast-twitch skeletal muscle contraction", "up-regulation of fast-twitch skeletal muscle contraction", "positive regulation of fast-twitch skeletal muscle contraction"], "types": ["T040"], "canonical_name": "positive regulation of fast-twitch skeletal muscle fiber contraction", "definition": "Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction. [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2245221", "aliases": [], "types": ["T040"], "canonical_name": "activation of fast-twitch skeletal muscle contraction"}
{"concept_id": "C2245222", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of fast-twitch skeletal muscle contraction"}
{"concept_id": "C2245223", "aliases": ["regulation of slow-twitch skeletal muscle contraction"], "types": ["T040"], "canonical_name": "regulation of slow-twitch skeletal muscle fiber contraction", "definition": "Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction. [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2245224", "aliases": ["downregulation of slow-twitch skeletal muscle contraction", "down-regulation of slow-twitch skeletal muscle contraction", "down regulation of slow-twitch skeletal muscle contraction", "negative regulation of slow-twitch skeletal muscle contraction"], "types": ["T040"], "canonical_name": "negative regulation of slow-twitch skeletal muscle fiber contraction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction. [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2245225", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of slow-twitch skeletal muscle contraction"}
{"concept_id": "C2245226", "aliases": ["up-regulation of slow-twitch skeletal muscle contraction", "positive regulation of slow-twitch skeletal muscle contraction", "upregulation of slow-twitch skeletal muscle contraction", "up regulation of slow-twitch skeletal muscle contraction"], "types": ["T040"], "canonical_name": "positive regulation of slow-twitch skeletal muscle fiber contraction", "definition": "Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction. [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2245227", "aliases": [], "types": ["T040"], "canonical_name": "activation of slow-twitch skeletal muscle contraction"}
{"concept_id": "C2245228", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of slow-twitch skeletal muscle contraction"}
{"concept_id": "C2245229", "aliases": ["down regulation of heterochromatin formation", "down-regulation of heterochromatin formation", "downregulation of heterochromatin formation", "negative regulation of heterochromatin formation"], "types": ["T043"], "canonical_name": "negative regulation of heterochromatin assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation. [GOC:mah]"}
{"concept_id": "C2245230", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of heterochromatin formation"}
{"concept_id": "C2245231", "aliases": ["up regulation of heterochromatin formation", "positive regulation of heterochromatin formation", "up-regulation of heterochromatin formation", "upregulation of heterochromatin formation"], "types": ["T043"], "canonical_name": "positive regulation of heterochromatin assembly", "definition": "Any process that activates or increases the frequency, rate or extent of heterochromatin formation. [GOC:mah]"}
{"concept_id": "C2245232", "aliases": [], "types": ["T043"], "canonical_name": "activation of heterochromatin formation"}
{"concept_id": "C2245233", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of heterochromatin formation"}
{"concept_id": "C2245237", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mating type switching"}
{"concept_id": "C2245238", "aliases": [], "types": ["T043"], "canonical_name": "activation of mating type switching"}
{"concept_id": "C2245239", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mating type switching"}
{"concept_id": "C2245241", "aliases": [], "types": ["T043"], "canonical_name": "beta-glucan-containing cell wall organization and biogenesis"}
{"concept_id": "C2245242", "aliases": [], "types": ["T043"], "canonical_name": "chitin- and beta-glucan-containing cell wall organization and biogenesis"}
{"concept_id": "C2245243", "aliases": [], "types": ["T043"], "canonical_name": "chitin-containing cell wall organization and biogenesis"}
{"concept_id": "C2245244", "aliases": [], "types": ["T043"], "canonical_name": "activation of exit from mitosis"}
{"concept_id": "C2245245", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of exit from mitosis"}
{"concept_id": "C2245248", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of anthocyanin metabolic process"}
{"concept_id": "C2245249", "aliases": [], "types": ["T044"], "canonical_name": "activation of anthocyanin metabolic process"}
{"concept_id": "C2245250", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of anthocyanin metabolic process"}
{"concept_id": "C2245253", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of anthocyanin biosynthetic process"}
{"concept_id": "C2245254", "aliases": [], "types": ["T040"], "canonical_name": "activation of anthocyanin biosynthetic process"}
{"concept_id": "C2245255", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of anthocyanin biosynthetic process"}
{"concept_id": "C2245258", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of brain-derived neurotrophic factor receptor signaling pathway"}
{"concept_id": "C2245259", "aliases": [], "types": ["T040"], "canonical_name": "activation of brain-derived neurotrophic factor receptor signaling pathway"}
{"concept_id": "C2245260", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of brain-derived neurotrophic factor receptor signaling pathway"}
{"concept_id": "C2245263", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of brain-derived neurotrophic factor receptor activity"}
{"concept_id": "C2245264", "aliases": [], "types": ["T040"], "canonical_name": "activation of brain-derived neurotrophic factor receptor activity"}
{"concept_id": "C2245265", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of brain-derived neurotrophic factor receptor activity"}
{"concept_id": "C2245267", "aliases": ["ribosome-mediated transcriptional attenuation"], "types": ["T045"], "canonical_name": "transcriptional attenuation by ribosome", "definition": "A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch. [GOC:dh, GOC:mlg, ISBN:0198542682]"}
{"concept_id": "C2245268", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud neck polarisome", "definition": "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis. [PMID:9632790]"}
{"concept_id": "C2245269", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud tip polarisome", "definition": "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud. [PMID:9632790]"}
{"concept_id": "C2245270", "aliases": ["negative regulation of inositol 1,4,5-trisphosphate receptor activity", "down regulation of IP3 receptor activity", "downregulation of IP3 receptor activity", "down-regulation of IP3 receptor activity"], "types": ["T043"], "canonical_name": "negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. [GOC:dph, GOC:mah, GOC:signaling]"}
{"concept_id": "C2245271", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of IP3 receptor activity"}
{"concept_id": "C2245272", "aliases": [], "types": ["T040"], "canonical_name": "activation of IP3 receptor activity"}
{"concept_id": "C2245273", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of IP3 receptor activity"}
{"concept_id": "C2245274", "aliases": ["negative regulation of pyrexia", "down regulation of fever", "downregulation of fever", "down-regulation of fever"], "types": ["T040"], "canonical_name": "negative regulation of fever generation", "definition": "Any process that stops, prevents, or reduces the rate or extent of fever generation. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C2245275", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of fever"}
{"concept_id": "C2245276", "aliases": [], "types": ["T040"], "canonical_name": "activation of fever"}
{"concept_id": "C2245277", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of fever"}
{"concept_id": "C2245278", "aliases": ["upregulation of fever", "up regulation of fever", "positive regulation of pyrexia", "up-regulation of fever"], "types": ["T040"], "canonical_name": "positive regulation of fever generation", "definition": "Any process that activates or increases the frequency, rate, or extent of fever generation. [GOC:add]"}
{"concept_id": "C2245280", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synaptic vesicle fusion to presynaptic membrane"}
{"concept_id": "C2245281", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptic vesicle fusion to presynaptic membrane"}
{"concept_id": "C2245282", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of synaptic vesicle fusion to presynaptic membrane"}
{"concept_id": "C2245285", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myelination"}
{"concept_id": "C2245286", "aliases": [], "types": ["T043"], "canonical_name": "activation of myelination"}
{"concept_id": "C2245287", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of myelination"}
{"concept_id": "C2245289", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of neurological process"}
{"concept_id": "C2245290", "aliases": [], "types": ["T039"], "canonical_name": "activation of neurological process"}
{"concept_id": "C2245291", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of neurological process"}
{"concept_id": "C2245293", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of heat generation"}
{"concept_id": "C2245294", "aliases": [], "types": ["T040"], "canonical_name": "activation of heat generation"}
{"concept_id": "C2245295", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of heat generation"}
{"concept_id": "C2245298", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of heat dissipation"}
{"concept_id": "C2245299", "aliases": [], "types": ["T040"], "canonical_name": "activation of heat dissipation"}
{"concept_id": "C2245300", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of heat dissipation"}
{"concept_id": "C2245314", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of lipopolysaccharide-mediated signaling pathway"}
{"concept_id": "C2245316", "aliases": [], "types": ["T040"], "canonical_name": "activation of lipopolysaccharide-mediated signaling pathway"}
{"concept_id": "C2245318", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of lipopolysaccharide-mediated signaling pathway"}
{"concept_id": "C2245321", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of synaptic plasticity"}
{"concept_id": "C2245322", "aliases": [], "types": ["T042"], "canonical_name": "activation of synaptic plasticity"}
{"concept_id": "C2245323", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of synaptic plasticity"}
{"concept_id": "C2245326", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of synaptic metaplasticity"}
{"concept_id": "C2245327", "aliases": [], "types": ["T042"], "canonical_name": "activation of synaptic metaplasticity"}
{"concept_id": "C2245328", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of synaptic metaplasticity"}
{"concept_id": "C2245330", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxal transmembrane transporter activity", "definition": "Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. [GOC:mah]"}
{"concept_id": "C2245331", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxal phosphate transmembrane transporter activity", "definition": "Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6. [GOC:mah]"}
{"concept_id": "C2245332", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxamine transmembrane transporter activity", "definition": "Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. [GOC:mah]"}
{"concept_id": "C2245333", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxine transmembrane transporter activity", "definition": "Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. [GOC:mah]"}
{"concept_id": "C2245351", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of glucocorticoid metabolic process"}
{"concept_id": "C2245352", "aliases": [], "types": ["T040"], "canonical_name": "activation of glucocorticoid metabolic process"}
{"concept_id": "C2245353", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of glucocorticoid metabolic process"}
{"concept_id": "C2245356", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of glucocorticoid biosynthetic process"}
{"concept_id": "C2245357", "aliases": [], "types": ["T040"], "canonical_name": "activation of glucocorticoid biosynthetic process"}
{"concept_id": "C2245358", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of glucocorticoid biosynthetic process"}
{"concept_id": "C2245361", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of glucocorticoid catabolic process"}
{"concept_id": "C2245362", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucocorticoid catabolic process"}
{"concept_id": "C2245363", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of glucocorticoid catabolic process"}
{"concept_id": "C2245366", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of protein amino acid autophosphorylation"}
{"concept_id": "C2245367", "aliases": [], "types": ["T040"], "canonical_name": "activation of protein amino acid autophosphorylation"}
{"concept_id": "C2245368", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of protein amino acid autophosphorylation"}
{"concept_id": "C2245372", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fatty acid beta-oxidation"}
{"concept_id": "C2245373", "aliases": [], "types": ["T043"], "canonical_name": "activation of fatty acid beta-oxidation"}
{"concept_id": "C2245374", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of fatty acid beta-oxidation"}
{"concept_id": "C2245376", "aliases": [], "types": ["T044"], "canonical_name": "oligoglucan-branching glycosyltransferase activity"}
{"concept_id": "C2245378", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of TOR signaling pathway"}
{"concept_id": "C2245379", "aliases": [], "types": ["T040"], "canonical_name": "activation of TOR signaling pathway"}
{"concept_id": "C2245380", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of TOR signaling pathway"}
{"concept_id": "C2245381", "aliases": ["up regulation of TOR signaling pathway", "up-regulation of TOR signaling pathway", "positive regulation of target of rapamycin signalling pathway", "positive regulation of TOR signaling cascade", "positive regulation of TOR signaling pathway", "positive regulation of target of rapamycin signaling pathway", "positive regulation of TOR signalling pathway", "upregulation of TOR signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of TOR signaling", "definition": "Any process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah]"}
{"concept_id": "C2245383", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of ARF protein signal transduction"}
{"concept_id": "C2245384", "aliases": [], "types": ["T040"], "canonical_name": "activation of ARF protein signal transduction"}
{"concept_id": "C2245385", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of ARF protein signal transduction"}
{"concept_id": "C2245388", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Ran protein signal transduction"}
{"concept_id": "C2245389", "aliases": [], "types": ["T040"], "canonical_name": "activation of Ran protein signal transduction"}
{"concept_id": "C2245390", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of Ran protein signal transduction"}
{"concept_id": "C2245392", "aliases": [], "types": ["T043"], "canonical_name": "activation of insulin secretion"}
{"concept_id": "C2245393", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of insulin secretion"}
{"concept_id": "C2245396", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of translation in response to stress"}
{"concept_id": "C2245397", "aliases": [], "types": ["T045"], "canonical_name": "activation of translation in response to stress"}
{"concept_id": "C2245398", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of translation in response to stress"}
{"concept_id": "C2245400", "aliases": ["downregulation of translation initiation in response to stress", "down regulation of translation initiation in response to stress", "down-regulation of translation initiation in response to stress"], "types": ["T045"], "canonical_name": "negative regulation of translational initiation in response to stress", "definition": "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. [GOC:mah]"}
{"concept_id": "C2245401", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of translation initiation in response to stress"}
{"concept_id": "C2245402", "aliases": ["up-regulation of translation initiation in response to stress", "upregulation of translation initiation in response to stress", "up regulation of translation initiation in response to stress"], "types": ["T043"], "canonical_name": "positive regulation of translational initiation in response to stress", "definition": "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. [GOC:mah]"}
{"concept_id": "C2245403", "aliases": [], "types": ["T045"], "canonical_name": "activation of translation initiation in response to stress"}
{"concept_id": "C2245404", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of translation initiation in response to stress"}
{"concept_id": "C2245406", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of translation in response to osmotic stress"}
{"concept_id": "C2245407", "aliases": [], "types": ["T043"], "canonical_name": "activation of translation in response to osmotic stress"}
{"concept_id": "C2245408", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of translation in response to osmotic stress"}
{"concept_id": "C2245410", "aliases": ["downregulation of translation initiation in response to osmotic stress", "down-regulation of translation initiation in response to osmotic stress", "down regulation of translation initiation in response to osmotic stress"], "types": ["T043"], "canonical_name": "negative regulation of translational initiation in response to osmotic stress", "definition": "Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:mah]"}
{"concept_id": "C2245411", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of translation initiation in response to osmotic stress"}
{"concept_id": "C2245412", "aliases": ["up regulation of translation initiation in response to osmotic stress", "upregulation of translation initiation in response to osmotic stress", "up-regulation of translation initiation in response to osmotic stress"], "types": ["T045"], "canonical_name": "positive regulation of translational initiation in response to osmotic stress", "definition": "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:mah]"}
{"concept_id": "C2245413", "aliases": [], "types": ["T045"], "canonical_name": "activation of translation initiation in response to osmotic stress"}
{"concept_id": "C2245414", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of translation initiation in response to osmotic stress"}
{"concept_id": "C2245417", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of nuclease activity"}
{"concept_id": "C2245418", "aliases": [], "types": ["T045"], "canonical_name": "activation of nuclease activity"}
{"concept_id": "C2245419", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of nuclease activity"}
{"concept_id": "C2245422", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of deoxyribonuclease activity"}
{"concept_id": "C2245423", "aliases": [], "types": ["T045"], "canonical_name": "activation of deoxyribonuclease activity"}
{"concept_id": "C2245424", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of deoxyribonuclease activity"}
{"concept_id": "C2245427", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of endodeoxyribonuclease activity"}
{"concept_id": "C2245428", "aliases": [], "types": ["T040"], "canonical_name": "activation of endodeoxyribonuclease activity"}
{"concept_id": "C2245429", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of endodeoxyribonuclease activity"}
{"concept_id": "C2245431", "aliases": ["regulation of type III restriction endoribonuclease activity"], "types": ["T045"], "canonical_name": "regulation of type III site-specific deoxyribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity. [GOC:dph, GOC:mah]"}
{"concept_id": "C2245433", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of protein binding"}
{"concept_id": "C2245434", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein binding"}
{"concept_id": "C2245435", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of protein binding"}
{"concept_id": "C2245438", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of response to food"}
{"concept_id": "C2245439", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to food"}
{"concept_id": "C2245440", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of response to food"}
{"concept_id": "C2245443", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of appetite"}
{"concept_id": "C2245444", "aliases": [], "types": ["T040"], "canonical_name": "activation of appetite"}
{"concept_id": "C2245447", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of response to external stimulus"}
{"concept_id": "C2245448", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to external stimulus"}
{"concept_id": "C2245449", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of response to external stimulus"}
{"concept_id": "C2245452", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of response to extracellular stimulus"}
{"concept_id": "C2245453", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to extracellular stimulus"}
{"concept_id": "C2245454", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of response to extracellular stimulus"}
{"concept_id": "C2245457", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of response to nutrient levels"}
{"concept_id": "C2245458", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to nutrient levels"}
{"concept_id": "C2245459", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of response to nutrient levels"}
{"concept_id": "C2245463", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud neck septin collar", "definition": "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck. [GOC:krc, PMID:16009555]"}
{"concept_id": "C2245464", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud neck split septin rings", "definition": "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated. [GOC:krc, PMID:16009555]"}
{"concept_id": "C2245465", "aliases": ["cellular bud neck septin ring organisation"], "types": ["T043"], "canonical_name": "cellular bud neck septin ring organization", "definition": "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck. [GOC:mah]"}
{"concept_id": "C2245467", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomere maintenance"}
{"concept_id": "C2245468", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomere maintenance"}
{"concept_id": "C2245469", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of telomere maintenance"}
{"concept_id": "C2245472", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomere maintenance via recombination"}
{"concept_id": "C2245473", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomere maintenance via recombination"}
{"concept_id": "C2245474", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of telomere maintenance via recombination"}
{"concept_id": "C2245477", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomere maintenance via telomerase"}
{"concept_id": "C2245478", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomere maintenance via telomerase"}
{"concept_id": "C2245479", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of telomere maintenance via telomerase"}
{"concept_id": "C2245482", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomere maintenance via semi-conservative replication"}
{"concept_id": "C2245483", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomere maintenance via semi-conservative replication"}
{"concept_id": "C2245484", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of telomere maintenance via semi-conservative replication"}
{"concept_id": "C2245486", "aliases": ["Clr6 histone deacetylase complex II location", "Clr6 histone deacetylase complex II' location", "Rpd3S complex", "Clr6-CII", "Rpd3S complex location", "Rpd3C(S)", "Clr6 histone deacetylase complex II'", "Clr6S complex", "Clr6S complex location", "Rpd3S/Clr6-CII complex location", "Clr6 histone deacetylase complex II"], "types": ["T026"], "canonical_name": "Rpd3S/Clr6-CII complex", "definition": "A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species). [GOC:vw, PMID:12773392, PMID:17450151]"}
{"concept_id": "C2245488", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of synaptic transmission, cholinergic"}
{"concept_id": "C2245489", "aliases": [], "types": ["T042"], "canonical_name": "activation of synaptic transmission, cholinergic"}
{"concept_id": "C2245490", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of synaptic transmission, cholinergic"}
{"concept_id": "C2245492", "aliases": [], "types": ["T042"], "canonical_name": "activation of synaptic transmission, dopaminergic"}
{"concept_id": "C2245493", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of synaptic transmission, dopaminergic"}
{"concept_id": "C2245496", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of synaptic transmission, dopaminergic"}
{"concept_id": "C2245498", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of synaptic transmission, GABAergic"}
{"concept_id": "C2245499", "aliases": [], "types": ["T042"], "canonical_name": "activation of synaptic transmission, GABAergic"}
{"concept_id": "C2245500", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of synaptic transmission, GABAergic"}
{"concept_id": "C2245502", "aliases": ["down regulation of actin filament bundle formation", "downregulation of actin filament bundle formation", "down-regulation of actin filament bundle formation"], "types": ["T043"], "canonical_name": "negative regulation of actin filament bundle assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. [GOC:mah]"}
{"concept_id": "C2245503", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of actin filament bundle formation"}
{"concept_id": "C2245504", "aliases": [], "types": ["T043"], "canonical_name": "activation of actin filament bundle formation"}
{"concept_id": "C2245505", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of actin filament bundle formation"}
{"concept_id": "C2245506", "aliases": ["upregulation of actin filament bundle formation", "up-regulation of actin filament bundle formation", "up regulation of actin filament bundle formation"], "types": ["T043"], "canonical_name": "positive regulation of actin filament bundle assembly", "definition": "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. [GOC:mah]"}
{"concept_id": "C2245507", "aliases": [], "types": ["T043"], "definition": "Any process that modulates the frequency, rate or extent of store-operated calcium channel activity. [GOC:TermGenie]", "canonical_name": "regulation of store-operated calcium channel activity"}
{"concept_id": "C2245516", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport"}
{"concept_id": "C2245517", "aliases": [], "types": ["T045"], "canonical_name": "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport"}
{"concept_id": "C2245518", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport"}
{"concept_id": "C2245519", "aliases": ["up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport", "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport", "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport"], "types": ["T044"], "canonical_name": "positive regulation of nucleobase-containing compound transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2245521", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of nucleoside transport"}
{"concept_id": "C2245522", "aliases": [], "types": ["T040"], "canonical_name": "activation of nucleoside transport"}
{"concept_id": "C2245523", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of nucleoside transport"}
{"concept_id": "C2245526", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of purine nucleoside transport"}
{"concept_id": "C2245527", "aliases": [], "types": ["T040"], "canonical_name": "activation of purine nucleoside transport"}
{"concept_id": "C2245528", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of purine nucleoside transport"}
{"concept_id": "C2245531", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of adenosine transport"}
{"concept_id": "C2245532", "aliases": [], "types": ["T044"], "canonical_name": "activation of adenosine transport"}
{"concept_id": "C2245533", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of adenosine transport"}
{"concept_id": "C2245535", "aliases": ["tRNA(Ile)-lysidine synthetase activity", "tRNA(Ile)-2-lysyl-cytidine synthase activity"], "types": ["T045"], "canonical_name": "tRNA(Ile)-lysidine synthase activity", "definition": "Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine. [PMID:14527414]"}
{"concept_id": "C2245543", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of protein polymerization"}
{"concept_id": "C2245544", "aliases": [], "types": ["T040"], "canonical_name": "activation of protein polymerization"}
{"concept_id": "C2245545", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of protein polymerization"}
{"concept_id": "C2245548", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gonadotropin secretion"}
{"concept_id": "C2245549", "aliases": [], "types": ["T043"], "canonical_name": "activation of gonadotropin secretion"}
{"concept_id": "C2245550", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of gonadotropin secretion"}
{"concept_id": "C2245553", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA replication initiation"}
{"concept_id": "C2245554", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA replication initiation"}
{"concept_id": "C2245555", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of DNA replication initiation"}
{"concept_id": "C2245558", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of icosanoid secretion"}
{"concept_id": "C2245559", "aliases": [], "types": ["T043"], "canonical_name": "activation of icosanoid secretion"}
{"concept_id": "C2245560", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of icosanoid secretion"}
{"concept_id": "C2245563", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of prostaglandin secretion"}
{"concept_id": "C2245564", "aliases": [], "types": ["T043"], "canonical_name": "activation of prostaglandin secretion"}
{"concept_id": "C2245565", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of prostaglandin secretion"}
{"concept_id": "C2245567", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of Ras GTPase activity"}
{"concept_id": "C2245569", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of Rho GTPase activity"}
{"concept_id": "C2245572", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chondrocyte differentiation"}
{"concept_id": "C2245573", "aliases": [], "types": ["T043"], "canonical_name": "activation of chondrocyte differentiation"}
{"concept_id": "C2245574", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of chondrocyte differentiation"}
{"concept_id": "C2245577", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of activin secretion"}
{"concept_id": "C2245578", "aliases": [], "types": ["T043"], "canonical_name": "activation of activin secretion"}
{"concept_id": "C2245579", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of activin secretion"}
{"concept_id": "C2245582", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of inhibin secretion"}
{"concept_id": "C2245583", "aliases": [], "types": ["T043"], "canonical_name": "activation of inhibin secretion"}
{"concept_id": "C2245584", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of inhibin secretion"}
{"concept_id": "C2245587", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of aldosterone metabolic process"}
{"concept_id": "C2245588", "aliases": [], "types": ["T043"], "canonical_name": "activation of aldosterone metabolic process"}
{"concept_id": "C2245589", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of aldosterone metabolic process"}
{"concept_id": "C2245592", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of aldosterone biosynthetic process"}
{"concept_id": "C2245593", "aliases": [], "types": ["T040"], "canonical_name": "activation of aldosterone biosynthetic process"}
{"concept_id": "C2245594", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of aldosterone biosynthetic process"}
{"concept_id": "C2245597", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of hormone metabolic process"}
{"concept_id": "C2245598", "aliases": [], "types": ["T040"], "canonical_name": "activation of hormone metabolic process"}
{"concept_id": "C2245599", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of hormone metabolic process"}
{"concept_id": "C2245602", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hormone biosynthetic process"}
{"concept_id": "C2245604", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of lipid transport"}
{"concept_id": "C2245605", "aliases": [], "types": ["T044"], "canonical_name": "activation of lipid transport"}
{"concept_id": "C2245606", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of lipid transport"}
{"concept_id": "C2245609", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of sterol transport"}
{"concept_id": "C2245610", "aliases": [], "types": ["T044"], "canonical_name": "activation of sterol transport"}
{"concept_id": "C2245611", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of sterol transport"}
{"concept_id": "C2245614", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of cholesterol transport"}
{"concept_id": "C2245615", "aliases": [], "types": ["T040"], "canonical_name": "activation of cholesterol transport"}
{"concept_id": "C2245616", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of cholesterol transport"}
{"concept_id": "C2245619", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intracellular lipid transport"}
{"concept_id": "C2245620", "aliases": [], "types": ["T043"], "canonical_name": "activation of intracellular lipid transport"}
{"concept_id": "C2245621", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of intracellular lipid transport"}
{"concept_id": "C2245624", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intracellular sterol transport"}
{"concept_id": "C2245625", "aliases": [], "types": ["T043"], "canonical_name": "activation of intracellular sterol transport"}
{"concept_id": "C2245626", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of intracellular sterol transport"}
{"concept_id": "C2245629", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intracellular cholesterol transport"}
{"concept_id": "C2245630", "aliases": [], "types": ["T043"], "canonical_name": "activation of intracellular cholesterol transport"}
{"concept_id": "C2245631", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of intracellular cholesterol transport"}
{"concept_id": "C2245634", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intracellular transport"}
{"concept_id": "C2245635", "aliases": [], "types": ["T043"], "canonical_name": "activation of intracellular transport"}
{"concept_id": "C2245636", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of intracellular transport"}
{"concept_id": "C2245639", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of transporter activity"}
{"concept_id": "C2245640", "aliases": [], "types": ["T044"], "canonical_name": "activation of transporter activity"}
{"concept_id": "C2245641", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of transporter activity"}
{"concept_id": "C2245643", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of ion transporter activity"}
{"concept_id": "C2245644", "aliases": [], "types": ["T044"], "canonical_name": "activation of ion transporter activity"}
{"concept_id": "C2245645", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of ion transporter activity"}
{"concept_id": "C2245647", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sodium:hydrogen antiporter activity"}
{"concept_id": "C2245648", "aliases": [], "types": ["T039"], "canonical_name": "activation of sodium:hydrogen antiporter activity"}
{"concept_id": "C2245649", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of sodium:hydrogen antiporter activity"}
{"concept_id": "C2245652", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mismatch repair"}
{"concept_id": "C2245653", "aliases": [], "types": ["T045"], "canonical_name": "activation of mismatch repair"}
{"concept_id": "C2245654", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of mismatch repair"}
{"concept_id": "C2245662", "aliases": ["activation of phospholipase A2 activity", "phospholipase A2 activation"], "types": ["T044"], "canonical_name": "activation of phospholipase A2 activity", "definition": "Any process that initiates the activity of the inactive enzyme phospholipase A2. [GOC:mah]"}
{"concept_id": "C2245663", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of phospholipase A2 activity"}
{"concept_id": "C2245666", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of proteasomal ubiquitin-dependent protein catabolic process"}
{"concept_id": "C2245667", "aliases": [], "types": ["T043"], "canonical_name": "activation of proteasomal ubiquitin-dependent protein catabolic process"}
{"concept_id": "C2245668", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of proteasomal ubiquitin-dependent protein catabolic process"}
{"concept_id": "C2245671", "aliases": ["NAD(P)H-dependent alkenal/one oxidoreductase activity", "n-alkanal:NAD(P)+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-alkenal reductase [NAD(P)+] activity", "definition": "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+. [EC:1.3.1.74, PMID:16299173]"}
{"concept_id": "C2245672", "aliases": ["NADPH:2-alkenal alpha,beta-hydrogenase activity"], "types": ["T044"], "canonical_name": "2-alkenal reductase (NADP+) activity", "definition": "Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+. [GOC:bf, GOC:kad, PMID:16299173]"}
{"concept_id": "C2245674", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein oligomerization"}
{"concept_id": "C2245675", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein oligomerization"}
{"concept_id": "C2245676", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein oligomerization"}
{"concept_id": "C2245679", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein homooligomerization"}
{"concept_id": "C2245680", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein homooligomerization"}
{"concept_id": "C2245681", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein homooligomerization"}
{"concept_id": "C2245684", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytokinesis"}
{"concept_id": "C2245685", "aliases": [], "types": ["T043"], "canonical_name": "activation of cytokinesis"}
{"concept_id": "C2245686", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cytokinesis"}
{"concept_id": "C2245690", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of type I interferon production"}
{"concept_id": "C2245691", "aliases": [], "types": ["T040"], "canonical_name": "activation of type I interferon production"}
{"concept_id": "C2245692", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of type I interferon production"}
{"concept_id": "C2245695", "aliases": ["endosome transport via MVB sorting pathway"], "types": ["T043"], "canonical_name": "endosome transport via multivesicular body sorting pathway", "definition": "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment. [GOC:mah, PMID:12461556, PMID:16689637]"}
{"concept_id": "C2245696", "aliases": ["endosome to lysosome transport via MVB sorting pathway"], "types": ["T043"], "canonical_name": "endosome to lysosome transport via multivesicular body sorting pathway", "definition": "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome. [GOC:mah, PMID:12461556, PMID:16689637]"}
{"concept_id": "C2245697", "aliases": ["endosome to vacuole transport via MVB sorting pathway"], "types": ["T043"], "canonical_name": "late endosome to vacuole transport via multivesicular body sorting pathway", "definition": "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole. [GOC:mah, PMID:12461556, PMID:16689637]"}
{"concept_id": "C2245700", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein phosphatase type 2B activity"}
{"concept_id": "C2245702", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein phosphatase type 2B activity"}
{"concept_id": "C2245703", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of protein phosphatase type 2B activity"}
{"concept_id": "C2245704", "aliases": ["down regulation of phosphoprotein phosphatase activity", "down-regulation of phosphoprotein phosphatase activity", "downregulation of phosphoprotein phosphatase activity"], "types": ["T044"], "canonical_name": "negative regulation of phosphoprotein phosphatase activity", "definition": "Any process that stops or reduces the activity of a phosphoprotein phosphatase. [GOC:mah]"}
{"concept_id": "C2245705", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphoprotein phosphatase activity"}
{"concept_id": "C2245706", "aliases": ["up-regulation of phosphoprotein phosphatase activity", "upregulation of phosphoprotein phosphatase activity", "up regulation of phosphoprotein phosphatase activity"], "types": ["T044"], "canonical_name": "positive regulation of phosphoprotein phosphatase activity", "definition": "Any process that activates or increases the activity of a phosphoprotein phosphatase. [GOC:mah]"}
{"concept_id": "C2245707", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphoprotein phosphatase activity"}
{"concept_id": "C2245708", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of phosphoprotein phosphatase activity"}
{"concept_id": "C2245709", "aliases": ["SOD1-calcineurin complex location"], "types": ["T026"], "canonical_name": "SOD1-calcineurin complex", "definition": "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1. [GOC:mah, PMID:17324120]"}
{"concept_id": "C2245710", "aliases": [], "types": ["T044"], "canonical_name": "amino acid-exporting ATPase activity"}
{"concept_id": "C2245711", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-exporting ATPase activity"}
{"concept_id": "C2245712", "aliases": [], "types": ["T044"], "canonical_name": "cysteine exporter"}
{"concept_id": "C2245713", "aliases": [], "types": ["T044"], "canonical_name": "amino acid-importing ATPase activity"}
{"concept_id": "C2245714", "aliases": [], "types": ["T044"], "canonical_name": "D-methionine-exporting ATPase activity"}
{"concept_id": "C2245715", "aliases": [], "types": ["T044"], "canonical_name": "D-methionine exporter"}
{"concept_id": "C2245716", "aliases": [], "types": ["T044"], "canonical_name": "D-methionine-importing ATPase activity"}
{"concept_id": "C2245717", "aliases": [], "types": ["T044"], "canonical_name": "D-methionine importer"}
{"concept_id": "C2245718", "aliases": ["silicon efflux transporter activity"], "types": ["T044"], "canonical_name": "silicon efflux transmembrane transporter activity", "definition": "Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane. [GOC:mah, PMID:17625566]"}
{"concept_id": "C2245720", "aliases": ["somite rostrocaudal axis specification"], "types": ["T040"], "canonical_name": "somite rostral/caudal axis specification", "definition": "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary. [GOC:bf, PMID:16326386, PMID:17360776]"}
{"concept_id": "C2245721", "aliases": [], "types": ["T040"], "canonical_name": "somite rostrocaudal polarity"}
{"concept_id": "C2245722", "aliases": ["response to vitamin A acid"], "types": ["T043"], "canonical_name": "response to retinoic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:sl]"}
{"concept_id": "C2245723", "aliases": ["protein export from ER", "protein export from endoplasmic reticulum", "protein exit from ER"], "types": ["T043"], "canonical_name": "protein exit from endoplasmic reticulum", "definition": "The directed movement of proteins from the endoplasmic reticulum. [GOC:rb]"}
{"concept_id": "C2245724", "aliases": ["microvillus organisation", "microvillus organization and biogenesis"], "types": ["T043"], "canonical_name": "microvillus organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. [GOC:mah]"}
{"concept_id": "C2245725", "aliases": ["follicle cell microvillus organisation", "follicle cell microvillus organization and biogenesis"], "types": ["T043"], "canonical_name": "follicle cell microvillus organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments. [GOC:sart, PMID:16507588]"}
{"concept_id": "C2245726", "aliases": ["regulation of microvillus organization and biogenesis", "regulation of microvillus organisation"], "types": ["T043"], "canonical_name": "regulation of microvillus organization", "definition": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. [GOC:mah]"}
{"concept_id": "C2245727", "aliases": ["regulation of follicle cell microvillus organisation", "regulation of follicle cell microvillus organization and biogenesis"], "types": ["T043"], "canonical_name": "regulation of follicle cell microvillus organization", "definition": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. [GOC:mah]"}
{"concept_id": "C2245728", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microvillus length", "definition": "A process that modulates the length of a microvillus. [GOC:mah]"}
{"concept_id": "C2245729", "aliases": [], "types": ["T043"], "canonical_name": "regulation of follicle cell microvillus length", "definition": "A process that modulates the length of a microvillus on a follicle cell. [GOC:sart, PMID:16260500]"}
{"concept_id": "C2245730", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microvillus biogenesis"}
{"concept_id": "C2245731", "aliases": [], "types": ["T039"], "canonical_name": "regulation of cellular component size", "definition": "A process that modulates the size of a cellular component. [GOC:mah]"}
{"concept_id": "C2245732", "aliases": [], "types": ["T039"], "canonical_name": "regulation of cell projection size", "definition": "A process that modulates the size of a cell projection. [GOC:mah]"}
{"concept_id": "C2245733", "aliases": ["host-seeking behavior"], "types": ["T055"], "definition": "The specific behavior of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host. [GOC:mah, GOC:pr, PMID:11931033]", "canonical_name": "host-seeking behaviour"}
{"concept_id": "C2245734", "aliases": ["regulation of host-seeking behaviour"], "types": ["T040"], "canonical_name": "regulation of host-seeking behavior", "definition": "Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism. [GOC:mah]"}
{"concept_id": "C2245735", "aliases": ["downregulation of host-seeking behavior", "negative regulation of host-seeking behaviour", "down regulation of host-seeking behavior", "down-regulation of host-seeking behavior"], "types": ["T040"], "canonical_name": "negative regulation of host-seeking behavior", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of any behavior associated with finding a host organism. [GOC:mah]"}
{"concept_id": "C2245736", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of host-seeking behavior"}
{"concept_id": "C2245737", "aliases": ["upregulation of host-seeking behavior", "positive regulation of host-seeking behaviour", "up-regulation of host-seeking behavior", "up regulation of host-seeking behavior"], "types": ["T040"], "canonical_name": "positive regulation of host-seeking behavior", "definition": "Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism. [GOC:mah]"}
{"concept_id": "C2245738", "aliases": [], "types": ["T040"], "canonical_name": "activation of host-seeking behavior"}
{"concept_id": "C2245739", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of host-seeking behavior"}
{"concept_id": "C2245740", "aliases": ["cortical ER"], "types": ["T026"], "canonical_name": "cortical endoplasmic reticulum", "definition": "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. [GOC:se, PMID:10931860, PMID:17686782]"}
{"concept_id": "C2245741", "aliases": ["sulphiredoxin activity", "sulfiredoxin activity", "Srx1"], "types": ["T044"], "definition": "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R. [EC:1.8.98.2, PMID:16102934]", "canonical_name": "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity"}
{"concept_id": "C2245742", "aliases": [], "types": ["T044"], "canonical_name": "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]"}
{"concept_id": "C2245743", "aliases": ["mitochondrial protein biosynthesis", "mitochondrial protein anabolism", "mitochondrial protein synthesis", "mitochondrial protein translation", "mitochondrial protein formation"], "types": ["T045"], "canonical_name": "mitochondrial translation", "definition": "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. [GOC:go_curators]"}
{"concept_id": "C2245744", "aliases": ["plastid protein synthesis", "plastid protein anabolism", "plastid protein translation", "plastid protein formation", "plastid protein biosynthesis"], "types": ["T045"], "canonical_name": "plastid translation", "definition": "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. [GOC:go_curators]"}
{"concept_id": "C2245745", "aliases": ["CURI complex location"], "types": ["T026"], "canonical_name": "CURI complex", "definition": "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p. [PMID:17452446]"}
{"concept_id": "C2245746", "aliases": [], "types": ["T045"], "canonical_name": "deoxyribonucleoside binding", "definition": "Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose. [GOC:mah]"}
{"concept_id": "C2245747", "aliases": [], "types": ["T045"], "canonical_name": "purine deoxyribonucleoside binding", "definition": "Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose. [GOC:mah]"}
{"concept_id": "C2245748", "aliases": [], "types": ["T045"], "canonical_name": "pyrimidine deoxyribonucleoside binding", "definition": "Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose. [GOC:mah]"}
{"concept_id": "C2245749", "aliases": [], "types": ["T044"], "canonical_name": "ribonucleoside binding", "definition": "Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. [GOC:mah]"}
{"concept_id": "C2245750", "aliases": [], "types": ["T045"], "canonical_name": "purine ribonucleoside binding", "definition": "Binding to a purine ribonucleoside, a compound consisting of a purine base linked to ribose. [GOC:mah]"}
{"concept_id": "C2245751", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine ribonucleoside binding", "definition": "Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose. [GOC:mah]"}
{"concept_id": "C2245752", "aliases": [], "types": ["T044"], "canonical_name": "deoxyribonucleotide binding", "definition": "Binding to a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. [GOC:mah]"}
{"concept_id": "C2245753", "aliases": [], "types": ["T044"], "canonical_name": "ribonucleotide binding", "definition": "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. [GOC:mah]"}
{"concept_id": "C2245754", "aliases": [], "types": ["T045"], "canonical_name": "purine deoxyribonucleotide binding", "definition": "Binding to a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. [GOC:mah]"}
{"concept_id": "C2245755", "aliases": [], "types": ["T044"], "canonical_name": "purine ribonucleotide binding", "definition": "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. [GOC:mah]"}
{"concept_id": "C2245756", "aliases": [], "types": ["T045"], "canonical_name": "pyrimidine deoxyribonucleotide binding", "definition": "Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. [GOC:mah]"}
{"concept_id": "C2245757", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine ribonucleotide binding", "definition": "Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. [GOC:mah]"}
{"concept_id": "C2245758", "aliases": [], "types": ["T044"], "canonical_name": "adenyl deoxyribonucleotide binding", "definition": "Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. [GOC:mah]"}
{"concept_id": "C2245759", "aliases": [], "types": ["T044"], "canonical_name": "adenyl ribonucleotide binding", "definition": "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. [GOC:mah]"}
{"concept_id": "C2245760", "aliases": [], "types": ["T045"], "canonical_name": "guanyl deoxyribonucleotide binding", "definition": "Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety. [GOC:mah]"}
{"concept_id": "C2245761", "aliases": [], "types": ["T045"], "canonical_name": "guanyl ribonucleotide binding", "definition": "Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. [GOC:mah]"}
{"concept_id": "C2245762", "aliases": [], "types": ["T044"], "canonical_name": "dAMP binding", "definition": "Binding to dAMP, deoxyadenosine monophosphate. [GOC:mah]"}
{"concept_id": "C2245763", "aliases": [], "types": ["T044"], "canonical_name": "dADP binding", "definition": "Binding to dADP, deoxyadenosine diphosphate. [GOC:mah]"}
{"concept_id": "C2245764", "aliases": [], "types": ["T044"], "canonical_name": "dATP binding", "definition": "Binding to dATP, deoxyadenosine triphosphate. [GOC:mah]"}
{"concept_id": "C2245765", "aliases": [], "types": ["T044"], "canonical_name": "dGMP binding", "definition": "Binding to dGMP, deoxyguanosine monophosphate. [GOC:mah]"}
{"concept_id": "C2245766", "aliases": [], "types": ["T044"], "canonical_name": "dGDP binding", "definition": "Binding to dGDP, deoxyguanosine diphosphate. [GOC:mah]"}
{"concept_id": "C2245767", "aliases": [], "types": ["T044"], "canonical_name": "dGTP binding", "definition": "Binding to dGTP, deoxyguanosine triphosphate. [GOC:mah]"}
{"concept_id": "C2245768", "aliases": [], "types": ["T045"], "canonical_name": "general transcription from RNA polymerase II promoter"}
{"concept_id": "C2245769", "aliases": ["gene-specific transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "specific transcription from RNA polymerase II promoter"}
{"concept_id": "C2245770", "aliases": ["response to progesterone stimulus"], "types": ["T043"], "canonical_name": "response to progesterone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. [GOC:sl]"}
{"concept_id": "C2245771", "aliases": [], "types": ["T043"], "canonical_name": "response to vitamin K", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus. [GOC:sl]"}
{"concept_id": "C2245772", "aliases": ["response to vitamin K2", "response to menatetrenone"], "types": ["T043"], "canonical_name": "response to menaquinone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus. [GOC:sl]"}
{"concept_id": "C2245773", "aliases": ["response to vitamin K1"], "types": ["T043"], "canonical_name": "response to phylloquinone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus. [GOC:sl]"}
{"concept_id": "C2245774", "aliases": ["ATP-dependent 5' to 3' RNA helicase activity", "5' to 3' RNA helicase activity", "ATP-dependent 5'-3' RNA helicase activity"], "types": ["T045"], "canonical_name": "5'-3' RNA helicase activity", "definition": "Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis. [GOC:jp]"}
{"concept_id": "C2245776", "aliases": [], "types": ["T044"], "canonical_name": "O-linoleoyltransferase activity", "definition": "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule. [GOC:cb]"}
{"concept_id": "C2245777", "aliases": ["phosphatidylcholine:cardiolipin linoleoyltransferase"], "types": ["T044"], "canonical_name": "phosphatidylcholine:cardiolipin O-linoleoyltransferase activity", "definition": "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule. [GOC:cb, GOC:mah]"}
{"concept_id": "C2245778", "aliases": [], "types": ["T026"], "canonical_name": "aleurone grain membrane", "definition": "The lipid bilayer surrounding an aleurone grain. [GOC:ecd]"}
{"concept_id": "C2245779", "aliases": [], "types": ["T026"], "canonical_name": "apical lamina of hyaline layer", "definition": "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms. [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331]"}
{"concept_id": "C2245780", "aliases": [], "types": ["T043"], "canonical_name": "ER-dependent peroxisome biogenesis"}
{"concept_id": "C2245783", "aliases": [], "types": ["T045"], "canonical_name": "regulation of gene-specific transcription"}
{"concept_id": "C2245784", "aliases": [], "types": ["T026"], "canonical_name": "growth cone membrane", "definition": "The portion of the plasma membrane surrounding a growth cone. [GOC:mah]"}
{"concept_id": "C2245785", "aliases": ["MVE membrane", "multivesicular endosome membrane", "MVB membrane"], "types": ["T026"], "canonical_name": "multivesicular body membrane", "definition": "The lipid bilayer surrounding a multivesicular body. [GOC:mah]"}
{"concept_id": "C2245786", "aliases": [], "types": ["T026"], "canonical_name": "protein storage vacuole membrane", "definition": "The lipid bilayer surrounding a protein storage vacuole. [GOC:mah]"}
{"concept_id": "C2245787", "aliases": ["trans Golgi network membrane"], "types": ["T026"], "canonical_name": "trans-Golgi network membrane", "definition": "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. [GOC:mah]"}
{"concept_id": "C2245788", "aliases": [], "types": ["T026"], "canonical_name": "Golgi trans face membrane"}
{"concept_id": "C2245789", "aliases": [], "types": ["T026"], "canonical_name": "neuron projection membrane", "definition": "The portion of the plasma membrane surrounding a neuron projection. [GOC:mah]"}
{"concept_id": "C2245790", "aliases": [], "types": ["T026"], "canonical_name": "dendrite membrane", "definition": "The portion of the plasma membrane surrounding a dendrite. [GOC:mah]"}
{"concept_id": "C2245791", "aliases": [], "types": ["T026"], "canonical_name": "dendritic spine membrane", "definition": "The portion of the plasma membrane surrounding a dendritic spine. [GOC:mah]"}
{"concept_id": "C2245792", "aliases": ["integral to mitochondrial membrane"], "types": ["T026"], "canonical_name": "integral component of mitochondrial membrane", "definition": "The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C2245793", "aliases": ["IRC", "GLUT4 storage compartment", "GSC"], "types": ["T026"], "definition": "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2. [PMID:17644329]", "canonical_name": "insulin-responsive compartment"}
{"concept_id": "C2245794", "aliases": ["protein translocation within membrane"], "types": ["T043"], "canonical_name": "protein transport within lipid bilayer", "definition": "The directed movement of a protein from one location to another within a lipid bilayer. [GOC:mah]"}
{"concept_id": "C2245795", "aliases": [], "types": ["T043"], "canonical_name": "receptor translocation within membrane"}
{"concept_id": "C2245796", "aliases": [], "types": ["T043"], "canonical_name": "receptor transport within lipid bilayer"}
{"concept_id": "C2245797", "aliases": ["B cell receptor translocation within membrane", "BCR translocation within membrane", "BCR transport within lipid bilayer"], "types": ["T043"], "canonical_name": "B cell receptor transport within lipid bilayer", "definition": "The directed movement of a B cell receptor within a lipid bilayer. [GOC:mah]"}
{"concept_id": "C2245798", "aliases": ["protein transport into lipid raft", "protein translocation into membrane raft"], "types": ["T043"], "canonical_name": "protein transport into membrane raft", "definition": "The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. [GOC:mah]"}
{"concept_id": "C2245799", "aliases": [], "types": ["T043"], "canonical_name": "receptor translocation into membrane raft"}
{"concept_id": "C2245800", "aliases": [], "types": ["T043"], "canonical_name": "receptor transport into membrane raft"}
{"concept_id": "C2245801", "aliases": ["B cell receptor transport into lipid raft", "B cell receptor translocation into membrane raft", "BCR transport into membrane raft", "BCR translocation into membrane raft"], "types": ["T043"], "canonical_name": "B cell receptor transport into membrane raft", "definition": "The directed movement of a B cell receptor into a membrane raft. [GOC:mah]"}
{"concept_id": "C2245802", "aliases": ["BCR transport into immunological synapse", "BCR translocation into immunological synapse", "B cell receptor translocation into immunological synapse"], "types": ["T043"], "canonical_name": "B cell receptor transport into immunological synapse", "definition": "The directed movement of a B cell receptor into an immunological synapse. [GOC:mah]"}
{"concept_id": "C2245803", "aliases": ["protein transport out of lipid raft", "protein translocation out of membrane raft"], "types": ["T043"], "canonical_name": "protein transport out of membrane raft", "definition": "The directed movement of a protein out of a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. [GOC:mah]"}
{"concept_id": "C2245804", "aliases": [], "types": ["T043"], "canonical_name": "receptor translocation out of membrane raft"}
{"concept_id": "C2245805", "aliases": [], "types": ["T043"], "canonical_name": "receptor transport out of membrane raft"}
{"concept_id": "C2245806", "aliases": ["chemokine receptor transport out of lipid raft", "chemokine receptor translocation out of membrane raft"], "types": ["T043"], "canonical_name": "chemokine receptor transport out of membrane raft", "definition": "The directed movement of a chemokine receptor out of a membrane raft. [GOC:mah]"}
{"concept_id": "C2245810", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of chemokine production"}
{"concept_id": "C2245812", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of connective tissue growth factor production"}
{"concept_id": "C2245814", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of fractalkine production"}
{"concept_id": "C2245816", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of granulocyte macrophage colony-stimulating factor production"}
{"concept_id": "C2245818", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of hepatocyte growth factor production"}
{"concept_id": "C2245820", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interferon-alpha production"}
{"concept_id": "C2245822", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interferon-beta production"}
{"concept_id": "C2245824", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interferon-gamma production"}
{"concept_id": "C2245827", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-1 alpha production"}
{"concept_id": "C2245829", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-1 beta production"}
{"concept_id": "C2245831", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-1 production"}
{"concept_id": "C2245833", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-10 production"}
{"concept_id": "C2245835", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-11 production"}
{"concept_id": "C2245837", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-12 production"}
{"concept_id": "C2245839", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-13 production"}
{"concept_id": "C2245843", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-15 production"}
{"concept_id": "C2245845", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-16 production"}
{"concept_id": "C2245847", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-17 production"}
{"concept_id": "C2245849", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-18 production"}
{"concept_id": "C2245851", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-19 production"}
{"concept_id": "C2245853", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-2 production"}
{"concept_id": "C2245855", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-20 production"}
{"concept_id": "C2245859", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-22 production"}
{"concept_id": "C2245861", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-23 production"}
{"concept_id": "C2245863", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-24 production"}
{"concept_id": "C2245865", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-25 production"}
{"concept_id": "C2245867", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-26 production"}
{"concept_id": "C2245869", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-27 production"}
{"concept_id": "C2245871", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-3 production"}
{"concept_id": "C2245873", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-4 production"}
{"concept_id": "C2245875", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-5 production"}
{"concept_id": "C2245877", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-6 production"}
{"concept_id": "C2245879", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-7 production"}
{"concept_id": "C2245881", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-8 production"}
{"concept_id": "C2245883", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of interleukin-9 production"}
{"concept_id": "C2245885", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of TRAIL production"}
{"concept_id": "C2245886", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of tumor necrosis factor production"}
{"concept_id": "C2245887", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of lymphotoxin A production"}
{"concept_id": "C2245888", "aliases": [], "types": ["T040"], "canonical_name": "activation of chemokine production"}
{"concept_id": "C2245889", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of chemokine production"}
{"concept_id": "C2245891", "aliases": [], "types": ["T040"], "canonical_name": "activation of connective tissue growth factor production"}
{"concept_id": "C2245892", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of connective tissue growth factor production"}
{"concept_id": "C2245894", "aliases": [], "types": ["T040"], "canonical_name": "activation of fractalkine production"}
{"concept_id": "C2245895", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of fractalkine production"}
{"concept_id": "C2245897", "aliases": [], "types": ["T040"], "canonical_name": "activation of granulocyte macrophage colony-stimulating factor production"}
{"concept_id": "C2245898", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of granulocyte macrophage colony-stimulating factor production"}
{"concept_id": "C2245900", "aliases": [], "types": ["T040"], "canonical_name": "activation of hepatocyte growth factor production"}
{"concept_id": "C2245901", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of hepatocyte growth factor production"}
{"concept_id": "C2245903", "aliases": [], "types": ["T040"], "canonical_name": "activation of interferon-alpha production"}
{"concept_id": "C2245904", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interferon-alpha production"}
{"concept_id": "C2245906", "aliases": [], "types": ["T040"], "canonical_name": "activation of interferon-beta production"}
{"concept_id": "C2245907", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interferon-beta production"}
{"concept_id": "C2245909", "aliases": [], "types": ["T040"], "canonical_name": "activation of interferon-gamma production"}
{"concept_id": "C2245911", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interferon-gamma production"}
{"concept_id": "C2245913", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-1 alpha production"}
{"concept_id": "C2245914", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-1 alpha production"}
{"concept_id": "C2245916", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-1 beta production"}
{"concept_id": "C2245917", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-1 beta production"}
{"concept_id": "C2245919", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-1 production"}
{"concept_id": "C2245920", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-1 production"}
{"concept_id": "C2245922", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-10 production"}
{"concept_id": "C2245923", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-10 production"}
{"concept_id": "C2245925", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-11 production"}
{"concept_id": "C2245926", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-11 production"}
{"concept_id": "C2245928", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-12 production"}
{"concept_id": "C2245929", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-12 production"}
{"concept_id": "C2245931", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-13 production"}
{"concept_id": "C2245932", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-13 production"}
{"concept_id": "C2245937", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-15 production"}
{"concept_id": "C2245938", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-15 production"}
{"concept_id": "C2245940", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-16 production"}
{"concept_id": "C2245941", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-16 production"}
{"concept_id": "C2245943", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-17 production"}
{"concept_id": "C2245944", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-17 production"}
{"concept_id": "C2245946", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-18 production"}
{"concept_id": "C2245947", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-18 production"}
{"concept_id": "C2245949", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-19 production"}
{"concept_id": "C2245950", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-19 production"}
{"concept_id": "C2245952", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-2 production"}
{"concept_id": "C2245953", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-2 production"}
{"concept_id": "C2245955", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-20 production"}
{"concept_id": "C2245956", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-20 production"}
{"concept_id": "C2245958", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-21 production"}
{"concept_id": "C2245959", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-21 production"}
{"concept_id": "C2245961", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-22 production"}
{"concept_id": "C2245962", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-22 production"}
{"concept_id": "C2245964", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-23 production"}
{"concept_id": "C2245965", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-23 production"}
{"concept_id": "C2245967", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-24 production"}
{"concept_id": "C2245968", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-24 production"}
{"concept_id": "C2245970", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-25 production"}
{"concept_id": "C2245971", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-25 production"}
{"concept_id": "C2245973", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-26 production"}
{"concept_id": "C2245974", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-26 production"}
{"concept_id": "C2245976", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-27 production"}
{"concept_id": "C2245977", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-27 production"}
{"concept_id": "C2245979", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-3 production"}
{"concept_id": "C2245980", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-3 production"}
{"concept_id": "C2245983", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell mediated cytotoxicity"}
{"concept_id": "C2245984", "aliases": [], "types": ["T043"], "canonical_name": "activation of T cell mediated cytotoxicity"}
{"concept_id": "C2245985", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T cell mediated cytotoxicity"}
{"concept_id": "C2245988", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of receptor recycling"}
{"concept_id": "C2245989", "aliases": [], "types": ["T044"], "canonical_name": "activation of receptor recycling"}
{"concept_id": "C2245990", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of receptor recycling"}
{"concept_id": "C2245993", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of B-1 B cell differentiation"}
{"concept_id": "C2245994", "aliases": [], "types": ["T043"], "canonical_name": "activation of B-1 B cell differentiation"}
{"concept_id": "C2245995", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of B-1 B cell differentiation"}
{"concept_id": "C2245998", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of exocyst assembly"}
{"concept_id": "C2245999", "aliases": [], "types": ["T043"], "canonical_name": "activation of exocyst assembly"}
{"concept_id": "C2246000", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of exocyst assembly"}
{"concept_id": "C2246003", "aliases": ["down regulation of protein amino acid phosphorylation", "downregulation of protein amino acid phosphorylation", "down-regulation of protein amino acid phosphorylation", "negative regulation of protein amino acid phosphorylation"], "types": ["T044"], "canonical_name": "negative regulation of protein phosphorylation", "definition": "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. [GOC:hjd]"}
{"concept_id": "C2246004", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of protein amino acid phosphorylation"}
{"concept_id": "C2246005", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein amino acid phosphorylation"}
{"concept_id": "C2246006", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of protein amino acid phosphorylation"}
{"concept_id": "C2246007", "aliases": ["upregulation of protein amino acid phosphorylation", "positive regulation of protein amino acid phosphorylation", "up regulation of protein amino acid phosphorylation", "up-regulation of protein amino acid phosphorylation"], "types": ["T044"], "canonical_name": "positive regulation of protein phosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]"}
{"concept_id": "C2246009", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelial cell proliferation"}
{"concept_id": "C2246010", "aliases": [], "types": ["T043"], "canonical_name": "activation of endothelial cell proliferation"}
{"concept_id": "C2246011", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of endothelial cell proliferation"}
{"concept_id": "C2246015", "aliases": [], "types": ["T044"], "canonical_name": "activation of cell-matrix adhesion"}
{"concept_id": "C2246016", "aliases": [], "types": ["T026"], "canonical_name": "stimulation of cell-matrix adhesion"}
{"concept_id": "C2246018", "aliases": [], "types": ["T043"], "canonical_name": "activation of neurotransmitter secretion"}
{"concept_id": "C2246019", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neurotransmitter secretion"}
{"concept_id": "C2246026", "aliases": [], "types": ["T043"], "canonical_name": "activation of activation of membrane attack complex"}
{"concept_id": "C2246027", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of activation of membrane attack complex"}
{"concept_id": "C2246030", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of activation of membrane attack complex"}
{"concept_id": "C2246031", "aliases": ["blood pressure regulation by neurological process", "neurological system process involved in regulation of systemic arterial blood pressure", "neurological process involved in regulation of systemic arterial blood pressure"], "types": ["T040"], "canonical_name": "nervous system process involved in regulation of systemic arterial blood pressure", "definition": "The regulation of blood pressure mediated by detection of stimuli and a neurological response. [GOC:mtg_cardio, ISBN:0721643949]"}
{"concept_id": "C2246032", "aliases": [], "types": ["T039"], "canonical_name": "renal system process involved in regulation of blood volume", "definition": "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. [GOC:dph, GOC:tb, ISBN:0721643949]"}
{"concept_id": "C2246033", "aliases": [], "types": ["T039"], "canonical_name": "renal regulation of blood volume"}
{"concept_id": "C2246034", "aliases": ["carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback", "definition": "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control. [GOC:dph, GOC:tb, ISBN:0721643949]"}
{"concept_id": "C2246035", "aliases": ["chemoreceptor regulation of systemic arterial blood pressure", "regulation of systemic arterial blood pressure by chemoreceptor signalling"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by chemoreceptor signaling", "definition": "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. [GOC:dph, GOC:tb, ISBN:0721643949]"}
{"concept_id": "C2246036", "aliases": ["ischemic regulation of systemic arterial blood pressure"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by ischemic conditions", "definition": "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system. [GOC:dph, GOC:tb, ISBN:0721643949]"}
{"concept_id": "C2246038", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of heart contraction rate in baroreceptor response to increased blood pressure"}
{"concept_id": "C2246039", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure"}
{"concept_id": "C2246040", "aliases": ["decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure", "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure"], "types": ["T040"], "canonical_name": "negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure", "definition": "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure. [GOC:mtg_cardio, ISBN:0721643949]"}
{"concept_id": "C2246041", "aliases": [], "types": ["T040"], "canonical_name": "vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure", "definition": "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure. [ISBN:0721643949]"}
{"concept_id": "C2246045", "aliases": ["positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure"], "types": ["T040"], "canonical_name": "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure"}
{"concept_id": "C2246046", "aliases": [], "types": ["T040"], "canonical_name": "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure"}
{"concept_id": "C2246047", "aliases": [], "types": ["T044"], "canonical_name": "noradrenaline-adrenaline regulation of blood pressure"}
{"concept_id": "C2246049", "aliases": ["up regulation of heart contraction rate by epinephrine-norepinephrine", "positive regulation of heart contraction rate by adrenaline-noradrenaline", "positive regulation of cardiac contraction rate by epinephrine-norepinephrine", "upregulation of heart contraction rate by epinephrine-norepinephrine", "up-regulation of heart contraction rate by epinephrine-norepinephrine"], "types": ["T044"], "canonical_name": "positive regulation of heart rate by epinephrine-norepinephrine", "definition": "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction. [GOC:dph]"}
{"concept_id": "C2246050", "aliases": [], "types": ["T044"], "canonical_name": "activation of heart contraction rate by epinephrine-norepinephrine"}
{"concept_id": "C2246051", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of heart contraction rate by epinephrine-norepinephrine"}
{"concept_id": "C2246052", "aliases": ["increased force of heart contraction by adrenaline-noradrenaline", "increased force of heart contraction by epinephrine-norepinephrine", "increased strength of cardiac contraction by epinephrine-norepinephrine"], "types": ["T044"], "canonical_name": "positive regulation of the force of heart contraction by epinephrine-norepinephrine", "definition": "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings. [GOC:dph, GOC:mtg_cardio]"}
{"concept_id": "C2246053", "aliases": ["positive regulation of heart contraction by epinephrine-norepinephrine", "positive regulation of heart contraction by adrenaline-noradrenaline"], "types": ["T044"], "canonical_name": "positive regulation of heart contraction by adrenaline-noradrenaline"}
{"concept_id": "C2246054", "aliases": [], "types": ["T039"], "canonical_name": "renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure", "definition": "The physiological response of the kidneys to a decrease in blood flow. [GOC:dph]"}
{"concept_id": "C2246055", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-4 production"}
{"concept_id": "C2246056", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-4 production"}
{"concept_id": "C2246058", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-5 production"}
{"concept_id": "C2246059", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-5 production"}
{"concept_id": "C2246061", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-6 production"}
{"concept_id": "C2246062", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-6 production"}
{"concept_id": "C2246064", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-7 production"}
{"concept_id": "C2246065", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-7 production"}
{"concept_id": "C2246067", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-8 production"}
{"concept_id": "C2246068", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-8 production"}
{"concept_id": "C2246070", "aliases": [], "types": ["T040"], "canonical_name": "activation of interleukin-9 production"}
{"concept_id": "C2246071", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of interleukin-9 production"}
{"concept_id": "C2246073", "aliases": [], "types": ["T040"], "canonical_name": "activation of TRAIL production"}
{"concept_id": "C2246074", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of TRAIL production"}
{"concept_id": "C2246076", "aliases": [], "types": ["T040"], "canonical_name": "activation of tumor necrosis factor production"}
{"concept_id": "C2246077", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of tumor necrosis factor production"}
{"concept_id": "C2246078", "aliases": [], "types": ["T040"], "canonical_name": "activation of lymphotoxin A production"}
{"concept_id": "C2246079", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of lymphotoxin A production"}
{"concept_id": "C2246080", "aliases": [], "types": ["T040"], "canonical_name": "regulation of mast cell cytokine production", "definition": "Any process that modulates the frequency, rate, or extent of mast cell cytokine production. [GOC:mah]"}
{"concept_id": "C2246081", "aliases": ["downregulation of mast cell cytokine production", "down-regulation of mast cell cytokine production", "down regulation of mast cell cytokine production"], "types": ["T040"], "canonical_name": "negative regulation of mast cell cytokine production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production. [GOC:mah]"}
{"concept_id": "C2246082", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of mast cell cytokine production"}
{"concept_id": "C2246083", "aliases": ["up-regulation of mast cell cytokine production", "upregulation of mast cell cytokine production", "up regulation of mast cell cytokine production"], "types": ["T040"], "canonical_name": "positive regulation of mast cell cytokine production", "definition": "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production. [GOC:mah]"}
{"concept_id": "C2246084", "aliases": [], "types": ["T040"], "canonical_name": "activation of mast cell cytokine production"}
{"concept_id": "C2246085", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of mast cell cytokine production"}
{"concept_id": "C2246087", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of monooxygenase activity"}
{"concept_id": "C2246088", "aliases": [], "types": ["T040"], "canonical_name": "activation of monooxygenase activity"}
{"concept_id": "C2246089", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of monooxygenase activity"}
{"concept_id": "C2246091", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of monophenol oxygenase activity"}
{"concept_id": "C2246092", "aliases": [], "types": ["T040"], "canonical_name": "activation of monophenol oxygenase activity"}
{"concept_id": "C2246093", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of monophenol oxygenase activity"}
{"concept_id": "C2246095", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of ATPase activity"}
{"concept_id": "C2246096", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATPase activity"}
{"concept_id": "C2246097", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of ATPase activity"}
{"concept_id": "C2246099", "aliases": ["down-regulation of RNA elongation", "downregulation of RNA elongation"], "types": ["T045"], "canonical_name": "down regulation of RNA elongation"}
{"concept_id": "C2246100", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of RNA elongation"}
{"concept_id": "C2246101", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA elongation"}
{"concept_id": "C2246102", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of RNA elongation"}
{"concept_id": "C2246103", "aliases": ["upregulation of RNA elongation", "up-regulation of RNA elongation"], "types": ["T045"], "canonical_name": "up regulation of RNA elongation"}
{"concept_id": "C2246104", "aliases": ["negative regulation of low-density lipoprotein receptor catabolism", "down regulation of low-density lipoprotein receptor catabolic process", "negative regulation of low-density lipoprotein receptor degradation", "negative regulation of low-density lipoprotein receptor catabolic process", "negative regulation of low-density lipoprotein receptor breakdown", "downregulation of low-density lipoprotein receptor catabolic process", "down-regulation of low-density lipoprotein receptor catabolic process"], "types": ["T043"], "canonical_name": "negative regulation of low-density lipoprotein particle receptor catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors. [GOC:mah]"}
{"concept_id": "C2246105", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of low-density lipoprotein receptor catabolic process"}
{"concept_id": "C2246106", "aliases": [], "types": ["T043"], "canonical_name": "activation of low-density lipoprotein receptor catabolic process"}
{"concept_id": "C2246107", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of low-density lipoprotein receptor catabolic process"}
{"concept_id": "C2246108", "aliases": ["positive regulation of low-density lipoprotein receptor catabolic process", "upregulation of low-density lipoprotein receptor catabolic process", "positive regulation of low-density lipoprotein receptor degradation", "up-regulation of low-density lipoprotein receptor catabolic process", "positive regulation of low-density lipoprotein receptor breakdown", "up regulation of low-density lipoprotein receptor catabolic process", "positive regulation of low-density lipoprotein receptor catabolism"], "types": ["T043"], "canonical_name": "positive regulation of low-density lipoprotein particle receptor catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors. [GOC:mah]"}
{"concept_id": "C2246110", "aliases": [], "types": ["T043"], "canonical_name": "activation of epinephrine secretion"}
{"concept_id": "C2246111", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of epinephrine secretion"}
{"concept_id": "C2246114", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell activation"}
{"concept_id": "C2246115", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell activation"}
{"concept_id": "C2246116", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell activation"}
{"concept_id": "C2246119", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell proliferation"}
{"concept_id": "C2246120", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell proliferation"}
{"concept_id": "C2246121", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell proliferation"}
{"concept_id": "C2246123", "aliases": ["down-regulation of natural killer cell proliferation during immune response", "downregulation of natural killer cell proliferation during immune response"], "types": ["T043"], "canonical_name": "down regulation of natural killer cell proliferation during immune response"}
{"concept_id": "C2246124", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell proliferation during immune response"}
{"concept_id": "C2246125", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell proliferation during immune response"}
{"concept_id": "C2246126", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell proliferation during immune response"}
{"concept_id": "C2246127", "aliases": ["upregulation of natural killer cell proliferation during immune response", "up-regulation of natural killer cell proliferation during immune response"], "types": ["T043"], "canonical_name": "up regulation of natural killer cell proliferation during immune response"}
{"concept_id": "C2246129", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell differentiation"}
{"concept_id": "C2246130", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell differentiation"}
{"concept_id": "C2246131", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell differentiation"}
{"concept_id": "C2246133", "aliases": ["down-regulation of natural killer cell differentiation during immune response", "downregulation of natural killer cell differentiation during immune response"], "types": ["T043"], "canonical_name": "down regulation of natural killer cell differentiation during immune response"}
{"concept_id": "C2246134", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell differentiation during immune response"}
{"concept_id": "C2246135", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell differentiation during immune response"}
{"concept_id": "C2246136", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell differentiation during immune response"}
{"concept_id": "C2246137", "aliases": ["upregulation of natural killer cell differentiation during immune response", "up-regulation of natural killer cell differentiation during immune response"], "types": ["T043"], "canonical_name": "up regulation of natural killer cell differentiation during immune response"}
{"concept_id": "C2246139", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"}
{"concept_id": "C2246140", "aliases": [], "types": ["T043"], "canonical_name": "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"}
{"concept_id": "C2246141", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"}
{"concept_id": "C2246143", "aliases": ["down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response", "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response"], "types": ["T043"], "canonical_name": "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response"}
{"concept_id": "C2246144", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response"}
{"concept_id": "C2246145", "aliases": ["positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response", "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response", "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response", "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response", "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response", "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response", "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response", "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response", "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response", "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response"], "types": ["T038"], "canonical_name": "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response", "definition": "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response. [GOC:mah]"}
{"concept_id": "C2246154", "aliases": ["regulation of reduction of pH in cell", "regulation of cell pH reduction", "regulation of reduction of cellular pH", "regulation of intracellular pH reduction", "regulation of cellular acidification"], "types": ["T039"], "canonical_name": "regulation of cellular pH reduction", "definition": "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell. [GOC:mah]"}
{"concept_id": "C2246155", "aliases": [], "types": ["T039"], "canonical_name": "regulation of intracellular acidification"}
{"concept_id": "C2246156", "aliases": ["negative regulation of reduction of pH in cell", "negative regulation of intracellular pH reduction", "downregulation of cellular pH reduction", "down regulation of cellular pH reduction", "negative regulation of cellular acidification", "negative regulation of cell pH reduction", "down-regulation of cellular pH reduction", "negative regulation of reduction of cellular pH"], "types": ["T039"], "canonical_name": "negative regulation of cellular pH reduction", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell. [GOC:mah]"}
{"concept_id": "C2246157", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cellular pH reduction"}
{"concept_id": "C2246158", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of intracellular acidification"}
{"concept_id": "C2246159", "aliases": ["positive regulation of intracellular pH reduction", "up regulation of cellular pH reduction", "positive regulation of reduction of pH in cell", "positive regulation of cell pH reduction", "positive regulation of cellular acidification", "upregulation of cellular pH reduction", "up-regulation of cellular pH reduction", "positive regulation of reduction of cellular pH"], "types": ["T039"], "canonical_name": "positive regulation of cellular pH reduction", "definition": "Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell. [GOC:mah]"}
{"concept_id": "C2246160", "aliases": [], "types": ["T039"], "canonical_name": "activation of cellular pH reduction"}
{"concept_id": "C2246161", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of intracellular acidification"}
{"concept_id": "C2246162", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of cellular pH reduction"}
{"concept_id": "C2246163", "aliases": ["up-regulation of ARF GTPase activity", "upregulation of ARF GTPase activity", "up regulation of ARF GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of ARF GTPase activity"}
{"concept_id": "C2246164", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of ARF GTPase activity"}
{"concept_id": "C2246165", "aliases": ["up-regulation of Rab GTPase activity", "up regulation of Rab GTPase activity", "upregulation of Rab GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of Rab GTPase activity"}
{"concept_id": "C2246166", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of Rab GTPase activity"}
{"concept_id": "C2246167", "aliases": ["up regulation of Ral GTPase activity", "upregulation of Ral GTPase activity", "up-regulation of Ral GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of Ral GTPase activity"}
{"concept_id": "C2246168", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of Ral GTPase activity"}
{"concept_id": "C2246169", "aliases": ["up regulation of Ran GTPase activity", "up-regulation of Ran GTPase activity", "upregulation of Ran GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of Ran GTPase activity"}
{"concept_id": "C2246170", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of Ran GTPase activity"}
{"concept_id": "C2246171", "aliases": ["up-regulation of Rap GTPase activity", "up regulation of Rap GTPase activity", "upregulation of Rap GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of Rap GTPase activity"}
{"concept_id": "C2246172", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of Rap GTPase activity"}
{"concept_id": "C2246173", "aliases": ["up-regulation of Rac GTPase activity", "up regulation of Rac GTPase activity", "upregulation of Rac GTPase activity"], "types": ["T044"], "canonical_name": "positive regulation of Rac GTPase activity"}
{"concept_id": "C2246174", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of Rac GTPase activity"}
{"concept_id": "C2246175", "aliases": ["activation of Ras GTPase activity"], "types": ["T044"], "canonical_name": "Ras GTPase activation"}
{"concept_id": "C2246176", "aliases": ["ARF GTPase activation"], "types": ["T044"], "canonical_name": "activation of ARF GTPase activity"}
{"concept_id": "C2246177", "aliases": ["activation of Rab GTPase activity"], "types": ["T044"], "canonical_name": "Rab GTPase activation"}
{"concept_id": "C2246178", "aliases": ["activation of Ral GTPase activity"], "types": ["T044"], "canonical_name": "Ral GTPase activation"}
{"concept_id": "C2246179", "aliases": ["activation of Ran GTPase activity"], "types": ["T044"], "canonical_name": "Ran GTPase activation"}
{"concept_id": "C2246180", "aliases": ["activation of Rap GTPase activity"], "types": ["T044"], "canonical_name": "Rap GTPase activation"}
{"concept_id": "C2246181", "aliases": ["activation of Rho GTPase activity"], "types": ["T044"], "canonical_name": "Rho GTPase activation"}
{"concept_id": "C2246182", "aliases": ["activation of Rac GTPase activity"], "types": ["T044"], "canonical_name": "Rac GTPase activation"}
{"concept_id": "C2246183", "aliases": ["Cdc42 GTPase activation"], "types": ["T044"], "canonical_name": "activation of Cdc42 GTPase activity"}
{"concept_id": "C2246184", "aliases": ["ER-mitochondria encounter structure", "Mdm10/Mdm12/Mmm1 complex location", "Mdm10/Mdm12/Mmm1 complex", "MMM1 complex", "ERMES complex location", "mitochore", "MMM1 complex location"], "types": ["T026"], "canonical_name": "ERMES complex", "definition": "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. [GOC:mcc, PMID:19556461, PMID:29279306]"}
{"concept_id": "C2246185", "aliases": [], "types": ["T044"], "canonical_name": "xylose reductase activity"}
{"concept_id": "C2246186", "aliases": [], "types": ["T044"], "canonical_name": "arabinose reductase activity"}
{"concept_id": "C2246187", "aliases": ["response to insulin stimulus"], "types": ["T043"], "canonical_name": "response to insulin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2246188", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to insulin stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2246189", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to hormone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:mah]"}
{"concept_id": "C2246190", "aliases": [], "types": ["T043"], "canonical_name": "regulation of karyogamy", "definition": "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion. [GOC:mah]"}
{"concept_id": "C2246191", "aliases": ["regulation of stress-activated MAPK signaling pathway", "regulation of stress-activated MAPKKK signaling pathway", "regulation of p38 MAPK signalling", "regulation of stress-activated MAPKKK cascade", "regulation of p38 MAPK signaling", "regulation of stress-activated MAPK signalling pathway", "regulation of stress-activated MAPKKK signalling pathway"], "types": ["T040"], "canonical_name": "regulation of stress-activated MAPK cascade", "definition": "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. [GOC:mah]"}
{"concept_id": "C2246192", "aliases": ["down-regulation of stress-activated MAPK cascade", "negative regulation of p38 MAPK signaling", "negative regulation of stress-activated MAPKKK signalling pathway", "negative regulation of p38 MAPK signalling", "downregulation of stress-activated MAPK cascade", "negative regulation of stress-activated MAPKKK cascade", "negative regulation of stress-activated MAPK signaling pathway", "negative regulation of stress-activated MAPK signalling pathway", "negative regulation of stress-activated MAPKKK signaling pathway", "down regulation of stress-activated MAPK cascade"], "types": ["T040"], "canonical_name": "negative regulation of stress-activated MAPK cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. [GOC:mah]"}
{"concept_id": "C2246193", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of stress-activated MAPK cascade"}
{"concept_id": "C2246194", "aliases": ["positive regulation of stress-activated MAPK signalling pathway", "positive regulation of stress-activated MAPKKK signaling pathway", "up-regulation of stress-activated MAPK cascade", "positive regulation of stress-activated MAPKKK cascade", "positive regulation of stress-activated MAPK signaling pathway", "up regulation of stress-activated MAPK cascade", "positive regulation of p38 MAPK signalling", "upregulation of stress-activated MAPK cascade", "positive regulation of p38 MAPK signaling", "positive regulation of stress-activated MAPKKK signalling pathway"], "types": ["T040"], "canonical_name": "positive regulation of stress-activated MAPK cascade", "definition": "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. [GOC:mah]"}
{"concept_id": "C2246195", "aliases": [], "types": ["T040"], "canonical_name": "activation of stress-activated MAPK cascade"}
{"concept_id": "C2246196", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of stress-activated MAPK cascade"}
{"concept_id": "C2246197", "aliases": ["regulation of DNA re-duplication", "regulation of DNA endoreplication"], "types": ["T045"], "canonical_name": "regulation of DNA endoreduplication", "definition": "Any process that modulates the frequency, rate or extent of DNA endoreduplication. [GOC:mah]"}
{"concept_id": "C2246198", "aliases": ["downregulation of DNA endoreduplication", "down-regulation of DNA endoreduplication", "down regulation of DNA endoreduplication", "negative regulation of DNA endoreplication", "negative regulation of DNA re-duplication"], "types": ["T045"], "canonical_name": "negative regulation of DNA endoreduplication", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication. [GOC:mah]"}
{"concept_id": "C2246199", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of DNA endoreduplication"}
{"concept_id": "C2246200", "aliases": ["upregulation of DNA endoreduplication", "up-regulation of DNA endoreduplication", "positive regulation of DNA re-duplication", "positive regulation of DNA endoreplication", "up regulation of DNA endoreduplication"], "types": ["T045"], "canonical_name": "positive regulation of DNA endoreduplication", "definition": "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication. [GOC:mah]"}
{"concept_id": "C2246201", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA endoreduplication"}
{"concept_id": "C2246202", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of DNA endoreduplication"}
{"concept_id": "C2246203", "aliases": [], "types": ["T039"], "canonical_name": "regulation of establishment or maintenance of cell polarity", "definition": "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. [GOC:mah]"}
{"concept_id": "C2246204", "aliases": ["regulation of localisation"], "types": ["T039"], "canonical_name": "regulation of localization", "definition": "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C2246205", "aliases": ["regulation of protein localisation", "regulation of cellular protein localization", "regulation of cellular protein localisation"], "types": ["T039"], "canonical_name": "regulation of protein localization", "definition": "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2246206", "aliases": [], "types": ["T043"], "canonical_name": "regulation of polysaccharide metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. [GOC:mah]"}
{"concept_id": "C2246207", "aliases": ["regulation of chitin metabolism"], "types": ["T043"], "canonical_name": "regulation of chitin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin. [GOC:mah]"}
{"concept_id": "C2246208", "aliases": ["regulation of chitin formation", "regulation of chitin anabolism", "regulation of chitin biosynthesis", "regulation of chitin synthesis"], "types": ["T043"], "canonical_name": "regulation of chitin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin. [GOC:mah]"}
{"concept_id": "C2246210", "aliases": ["regulation of cell wall chitin formation", "regulation of cell wall chitin anabolism", "regulation of cell wall chitin synthesis", "regulation of cell wall chitin biosynthesis"], "types": ["T043"], "canonical_name": "regulation of cell wall chitin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin. [GOC:mah]"}
{"concept_id": "C2246211", "aliases": [], "types": ["T043"], "canonical_name": "regulation of polysaccharide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. [GOC:mah]"}
{"concept_id": "C2246212", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microtubule-based process", "definition": "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. [GOC:mah]"}
{"concept_id": "C2246213", "aliases": [], "types": ["T043"], "canonical_name": "regulation of spindle elongation", "definition": "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle. [GOC:mah]"}
{"concept_id": "C2246214", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic spindle elongation", "definition": "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle. [GOC:mah]"}
{"concept_id": "C2246215", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vacuole fusion, non-autophagic", "definition": "Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole. [GOC:mah]"}
{"concept_id": "C2246216", "aliases": [], "types": ["T043"], "canonical_name": "regulation of organic acid transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2246217", "aliases": ["downregulation of organic acid transport", "down-regulation of organic acid transport", "down regulation of organic acid transport"], "types": ["T043"], "canonical_name": "negative regulation of organic acid transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2246218", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of organic acid transport"}
{"concept_id": "C2246219", "aliases": ["upregulation of organic acid transport", "up regulation of organic acid transport", "up-regulation of organic acid transport"], "types": ["T043"], "canonical_name": "positive regulation of organic acid transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2246220", "aliases": [], "types": ["T043"], "canonical_name": "activation of organic acid transport"}
{"concept_id": "C2246221", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of organic acid transport"}
{"concept_id": "C2246229", "aliases": ["palmitoyl-CoA delta9-desaturase acitivity"], "types": ["T044"], "canonical_name": "palmitoyl-CoA 9-desaturase activity", "definition": "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O. [GOC:kmv, PMID:16443825]"}
{"concept_id": "C2246230", "aliases": ["downregulation of viral transcription", "down regulation of viral transcription", "down-regulation of viral transcription"], "types": ["T045"], "canonical_name": "negative regulation of viral transcription", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. [GOC:mah]"}
{"concept_id": "C2246231", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of viral transcription"}
{"concept_id": "C2246232", "aliases": [], "types": ["T039"], "canonical_name": "neurotrophin production", "definition": "The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. [GOC:ecd, GOC:mah, GOC:mtg_MIT_16mar07]"}
{"concept_id": "C2246233", "aliases": [], "types": ["T039"], "canonical_name": "regulation of neurotrophin production", "definition": "Any process that modulates the frequency, rate, or extent of production of a neurotrophin. [GOC:mah]"}
{"concept_id": "C2246234", "aliases": ["downregulation of neurotrophin production", "down-regulation of neurotrophin production", "down regulation of neurotrophin production"], "types": ["T039"], "canonical_name": "negative regulation of neurotrophin production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin. [GOC:mah]"}
{"concept_id": "C2246235", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of neurotrophin production"}
{"concept_id": "C2246236", "aliases": ["up regulation of neurotrophin production", "upregulation of neurotrophin production", "up-regulation of neurotrophin production"], "types": ["T039"], "canonical_name": "positive regulation of neurotrophin production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin. [GOC:mah]"}
{"concept_id": "C2246237", "aliases": [], "types": ["T039"], "canonical_name": "activation of neurotrophin production"}
{"concept_id": "C2246238", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of neurotrophin production"}
{"concept_id": "C2246239", "aliases": ["beta-nerve growth factor production", "NGF production"], "types": ["T039"], "canonical_name": "nerve growth factor production", "definition": "The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. [GOC:ecd, GOC:mah]"}
{"concept_id": "C2246240", "aliases": ["regulation of beta-nerve growth factor production", "regulation of NGF production"], "types": ["T039"], "canonical_name": "regulation of nerve growth factor production", "definition": "Any process that modulates the frequency, rate, or extent of production of nerve growth factor (NGF). [GOC:mah]"}
{"concept_id": "C2246241", "aliases": ["downregulation of nerve growth factor production", "down-regulation of nerve growth factor production", "down regulation of nerve growth factor production", "negative regulation of NGF production"], "types": ["T039"], "canonical_name": "negative regulation of nerve growth factor production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF). [GOC:mah]"}
{"concept_id": "C2246242", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of nerve growth factor production"}
{"concept_id": "C2246243", "aliases": ["transforming growth factor-beta1 production", "TGF-B1 production", "TGFB1 production"], "types": ["T044"], "canonical_name": "transforming growth factor beta1 production", "definition": "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C2246244", "aliases": ["transforming growth factor-beta2 production", "TGF-B2 production", "TGFB2 production"], "types": ["T044"], "canonical_name": "transforming growth factor beta2 production", "definition": "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C2246245", "aliases": ["TGF-B3 production", "TGFB3 production", "transforming growth factor-beta3 production"], "types": ["T044"], "canonical_name": "transforming growth factor beta3 production", "definition": "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C2246246", "aliases": ["regulation of TGFB1 production", "regulation of TGF-B1 production", "regulation of transforming growth factor-beta1 production"], "types": ["T040"], "canonical_name": "regulation of transforming growth factor beta1 production", "definition": "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1. [GOC:mah]"}
{"concept_id": "C2246247", "aliases": ["regulation of TGFB2 production", "regulation of TGF-B2 production", "regulation of transforming growth factor-beta2 production"], "types": ["T040"], "canonical_name": "regulation of transforming growth factor beta2 production", "definition": "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2. [GOC:mah]"}
{"concept_id": "C2246248", "aliases": ["regulation of TGFB3 production", "regulation of transforming growth factor-beta3 production", "regulation of TGF-B3 production"], "types": ["T040"], "canonical_name": "regulation of transforming growth factor beta3 production", "definition": "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3. [GOC:mah]"}
{"concept_id": "C2246249", "aliases": ["negative regulation of TGFB1 production", "negative regulation of transforming growth factor-beta1 production", "negative regulation of TGF-B1 production", "down-regulation of transforming growth factor-beta1 production", "downregulation of transforming growth factor-beta1 production", "down regulation of transforming growth factor-beta1 production"], "types": ["T040"], "canonical_name": "negative regulation of transforming growth factor beta1 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1. [GOC:mah]"}
{"concept_id": "C2246250", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of transforming growth factor-beta1 production"}
{"concept_id": "C2246251", "aliases": ["down regulation of transforming growth factor-beta2 production", "negative regulation of TGF-B2 production", "negative regulation of transforming growth factor-beta2 production", "negative regulation of TGFB2 production", "down-regulation of transforming growth factor-beta2 production", "downregulation of transforming growth factor-beta2 production"], "types": ["T040"], "canonical_name": "negative regulation of transforming growth factor beta2 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2. [GOC:mah]"}
{"concept_id": "C2246252", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of transforming growth factor-beta2 production"}
{"concept_id": "C2246253", "aliases": ["down regulation of transforming growth factor-beta3 production", "downregulation of transforming growth factor-beta3 production", "negative regulation of TGF-B3 production", "negative regulation of TGFB3 production", "negative regulation of transforming growth factor-beta3 production", "down-regulation of transforming growth factor-beta3 production"], "types": ["T040"], "canonical_name": "negative regulation of transforming growth factor beta3 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3. [GOC:mah]"}
{"concept_id": "C2246254", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of transforming growth factor-beta3 production"}
{"concept_id": "C2246255", "aliases": ["positive regulation of TGF-B1 production", "up regulation of transforming growth factor-beta1 production", "positive regulation of TGFB1 production", "up-regulation of transforming growth factor-beta1 production", "upregulation of transforming growth factor-beta1 production"], "types": ["T040"], "canonical_name": "positive regulation of transforming growth factor beta1 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1. [GOC:mah]"}
{"concept_id": "C2246256", "aliases": [], "types": ["T040"], "canonical_name": "activation of transforming growth factor-beta1 production"}
{"concept_id": "C2246257", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of transforming growth factor-beta1 production"}
{"concept_id": "C2246258", "aliases": ["positive regulation of transforming growth factor-beta2 production", "up regulation of transforming growth factor-beta2 production", "positive regulation of TGFB2 production", "up-regulation of transforming growth factor-beta2 production", "upregulation of transforming growth factor-beta2 production", "positive regulation of TGF-B2 production"], "types": ["T040"], "canonical_name": "positive regulation of transforming growth factor beta2 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2. [GOC:mah]"}
{"concept_id": "C2246259", "aliases": [], "types": ["T040"], "canonical_name": "activation of transforming growth factor-beta2 production"}
{"concept_id": "C2246260", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of transforming growth factor-beta2 production"}
{"concept_id": "C2246261", "aliases": ["up-regulation of transforming growth factor-beta3 production", "positive regulation of TGFB3 production", "upregulation of transforming growth factor-beta3 production", "up regulation of transforming growth factor-beta3 production", "positive regulation of transforming growth factor-beta3 production", "positive regulation of TGF-B3 production"], "types": ["T040"], "canonical_name": "positive regulation of transforming growth factor beta3 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3. [GOC:mah]"}
{"concept_id": "C2246262", "aliases": [], "types": ["T040"], "canonical_name": "activation of transforming growth factor-beta3 production"}
{"concept_id": "C2246263", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of transforming growth factor-beta3 production"}
{"concept_id": "C2246264", "aliases": [], "types": ["T044"], "canonical_name": "polyamine acetylation", "definition": "The modification of polyamines by addition of acetyl groups. [GOC:mlg]"}
{"concept_id": "C2246265", "aliases": [], "types": ["T044"], "canonical_name": "spermidine acetylation", "definition": "The modification of spermidine by addition of acetyl groups. [GOC:mlg]"}
{"concept_id": "C2246266", "aliases": [], "types": ["T044"], "canonical_name": "spermine acetylation", "definition": "The modification of spermine by addition of acetyl groups. [GOC:mlg]"}
{"concept_id": "C2246267", "aliases": [], "types": ["T044"], "canonical_name": "putrescine acetylation", "definition": "The modification of putrescine by addition of acetyl groups. [GOC:mlg]"}
{"concept_id": "C2246268", "aliases": ["sarcosine oxidase complex location"], "types": ["T026"], "canonical_name": "sarcosine oxidase complex", "definition": "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity. [GOC:mah, GOC:mlg]"}
{"concept_id": "C2246269", "aliases": [], "types": ["T040"], "canonical_name": "circadian regulation of gene expression", "definition": "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. [GOC:mah]"}
{"concept_id": "C2246270", "aliases": [], "types": ["T040"], "canonical_name": "circadian regulation of protein expression"}
{"concept_id": "C2246271", "aliases": [], "types": ["T040"], "canonical_name": "diurnal variation of gene expression"}
{"concept_id": "C2246272", "aliases": [], "types": ["T040"], "canonical_name": "diurnal variation of protein expression"}
{"concept_id": "C2246273", "aliases": ["organophosphonate biosynthetic process"], "types": ["T044"], "canonical_name": "organic phosphonate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. [GOC:js]"}
{"concept_id": "C2246274", "aliases": ["activin receptor signalling pathway"], "types": ["T044"], "canonical_name": "activin receptor signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:rl, GOC:signaling]"}
{"concept_id": "C2246275", "aliases": ["regulation of activin receptor signalling pathway"], "types": ["T040"], "canonical_name": "regulation of activin receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2246276", "aliases": ["regulation of activin signalling pathway"], "types": ["T040"], "canonical_name": "regulation of activin signaling pathway"}
{"concept_id": "C2246277", "aliases": ["downregulation of activin receptor signaling pathway", "negative regulation of activin receptor signalling pathway", "down regulation of activin receptor signaling pathway", "down-regulation of activin receptor signaling pathway"], "types": ["T040"], "canonical_name": "negative regulation of activin receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2246278", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of activin receptor signaling pathway"}
{"concept_id": "C2246279", "aliases": ["negative regulation of activin signalling pathway"], "types": ["T040"], "canonical_name": "negative regulation of activin signaling pathway"}
{"concept_id": "C2246280", "aliases": ["positive regulation of activin receptor signalling pathway", "upregulation of activin receptor signaling pathway", "up regulation of activin receptor signaling pathway", "up-regulation of activin receptor signaling pathway"], "types": ["T040"], "canonical_name": "positive regulation of activin receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2246281", "aliases": [], "types": ["T044"], "canonical_name": "activation of activin receptor signaling pathway"}
{"concept_id": "C2246282", "aliases": ["positive regulation of activin signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of activin signaling pathway"}
{"concept_id": "C2246283", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of activin receptor signaling pathway"}
{"concept_id": "C2246284", "aliases": ["regulation of superoxide release"], "types": ["T040"], "canonical_name": "regulation of superoxide anion generation", "definition": "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell. [GOC:mah]"}
{"concept_id": "C2246286", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of superoxide release"}
{"concept_id": "C2246288", "aliases": [], "types": ["T040"], "canonical_name": "activation of superoxide release"}
{"concept_id": "C2246289", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of superoxide release"}
{"concept_id": "C2246290", "aliases": ["histone lysine N-acetyltransferase activity (H3-K56 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H3-K56 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56). [EC:2.3.1.48]"}
{"concept_id": "C2246291", "aliases": ["astral microtubule stabilization"], "types": ["T043"], "canonical_name": "negative regulation of astral microtubule depolymerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules. [GOC:mah]"}
{"concept_id": "C2246292", "aliases": ["sterol binding"], "types": ["T044"], "definition": "Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. [GOC:mah]", "canonical_name": "sterol carrier activity"}
{"concept_id": "C2246293", "aliases": ["sterol sensing activity"], "types": ["T044"], "canonical_name": "sterol sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol. [GOC:mah]"}
{"concept_id": "C2246294", "aliases": [], "types": ["T044"], "canonical_name": "sterol-sensing domain"}
{"concept_id": "C2246295", "aliases": ["Sre1-Scp1 complex", "SREBP-SCAP complex location", "Sre1-Scp1 complex location"], "types": ["T026"], "canonical_name": "SREBP-SCAP complex", "definition": "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. [PMID:12923525]"}
{"concept_id": "C2246296", "aliases": ["SREBP-SCAP-Insig complex location"], "types": ["T026"], "canonical_name": "SREBP-SCAP-Insig complex", "definition": "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane. [PMID:12923525]"}
{"concept_id": "C2246297", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of translation in response to oxidative stress", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah]"}
{"concept_id": "C2246298", "aliases": ["up-regulation of translation in response to oxidative stress", "up regulation of translation in response to oxidative stress", "upregulation of translation in response to oxidative stress"], "types": ["T043"], "canonical_name": "positive regulation of translation in response to oxidative stress", "definition": "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah]"}
{"concept_id": "C2246299", "aliases": [], "types": ["T045"], "canonical_name": "activation of translation in response to oxidative stress"}
{"concept_id": "C2246300", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of translation in response to oxidative stress"}
{"concept_id": "C2246301", "aliases": ["tissue secretion"], "types": ["T039"], "canonical_name": "secretion by tissue", "definition": "The controlled release of a substance by a tissue. [GOC:mah]"}
{"concept_id": "C2246302", "aliases": ["1D-myo-inositol-tetrakisphosphate 2-kinase activity", "inositol-tetrakisphosphate 2-kinase activity", "inositol 1,3,4,6-tetrakisphosphate 2-kinase activity"], "types": ["T044"], "canonical_name": "inositol tetrakisphosphate 2-kinase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP. [GOC:hf]"}
{"concept_id": "C2246303", "aliases": [], "types": ["T043"], "canonical_name": "mononuclear cell proliferation", "definition": "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. [GOC:add]"}
{"concept_id": "C2246304", "aliases": [], "types": ["T043"], "canonical_name": "PBMC proliferation"}
{"concept_id": "C2246305", "aliases": [], "types": ["T043"], "canonical_name": "peripheral blood mononuclear cell proliferation"}
{"concept_id": "C2246306", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mononuclear cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. [GOC:add]"}
{"concept_id": "C2246307", "aliases": [], "types": ["T043"], "canonical_name": "regulation of PBMC proliferation"}
{"concept_id": "C2246308", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peripheral blood mononuclear cell proliferation"}
{"concept_id": "C2246309", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mononuclear cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. [GOC:add]"}
{"concept_id": "C2246310", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of PBMC proliferation"}
{"concept_id": "C2246311", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of peripheral blood mononuclear cell proliferation"}
{"concept_id": "C2246312", "aliases": ["up-regulation of mononuclear cell proliferation", "up regulation of mononuclear cell proliferation", "upregulation of mononuclear cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of mononuclear cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. [GOC:add]"}
{"concept_id": "C2246313", "aliases": [], "types": ["T043"], "canonical_name": "activation of mononuclear cell proliferation"}
{"concept_id": "C2246314", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of PBMC proliferation"}
{"concept_id": "C2246315", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of peripheral blood mononuclear cell proliferation"}
{"concept_id": "C2246316", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mononuclear cell proliferation"}
{"concept_id": "C2246317", "aliases": [], "types": ["T044"], "canonical_name": "protein-containing complex scaffold activity"}
{"concept_id": "C2246318", "aliases": ["regulation of alpha-glucan metabolism"], "types": ["T040"], "canonical_name": "regulation of alpha-glucan metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans. [GOC:mah]"}
{"concept_id": "C2246319", "aliases": ["regulation of alpha-glucan biosynthesis", "regulation of alpha-glucan formation", "regulation of alpha-glucan anabolism", "regulation of alpha-glucan synthesis"], "types": ["T043"], "canonical_name": "regulation of alpha-glucan biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans. [GOC:mah]"}
{"concept_id": "C2246320", "aliases": ["regulation of beta-glucan metabolism"], "types": ["T040"], "canonical_name": "regulation of beta-glucan metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans. [GOC:mah]"}
{"concept_id": "C2246321", "aliases": ["regulation of beta-glucan synthesis", "regulation of beta-glucan anabolism", "regulation of beta-glucan formation", "regulation of beta-glucan biosynthesis"], "types": ["T043"], "canonical_name": "regulation of beta-glucan biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans. [GOC:mah]"}
{"concept_id": "C2246322", "aliases": ["regulation of 1,3-beta-glucan metabolism", "regulation of (1->3)-beta-D-glucan metabolism", "regulation of 1,3-beta-D-glucan metabolic process"], "types": ["T043"], "canonical_name": "regulation of (1->3)-beta-D-glucan metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans. [GOC:mah]"}
{"concept_id": "C2246323", "aliases": ["regulation of 1,3-beta-glucan synthesis", "regulation of 1,3-beta-glucan biosynthesis", "regulation of 1,3-beta-glucan anabolism", "regulation of 1,3-beta-glucan formation"], "types": ["T043"], "canonical_name": "regulation of (1->3)-beta-D-glucan biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans. [GOC:mah]"}
{"concept_id": "C2246324", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytokinetic process", "definition": "Any process that modulates the frequency, rate or extent of a cytokinetic process. [GOC:mah]"}
{"concept_id": "C2246325", "aliases": ["regulation of division septum formation"], "types": ["T043"], "canonical_name": "regulation of division septum assembly", "definition": "Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806]"}
{"concept_id": "C2246326", "aliases": ["regulation of actin cytoskeleton organization and biogenesis", "regulation of actin cytoskeleton organisation"], "types": ["T043"], "canonical_name": "regulation of actin cytoskeleton organization", "definition": "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:mah]"}
{"concept_id": "C2246327", "aliases": ["IP3 metabolism", "IP3 metabolic process", "inositol trisphosphate metabolism"], "types": ["T044"], "canonical_name": "inositol trisphosphate metabolic process", "definition": "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. [GOC:mah]"}
{"concept_id": "C2246328", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol trisphosphate metabolic process"}
{"concept_id": "C2246329", "aliases": ["inositol phosphate formation", "inositol phosphate anabolism", "inositol phosphate synthesis", "inositol phosphate biosynthesis"], "types": ["T044"], "canonical_name": "inositol phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:mah]"}
{"concept_id": "C2246330", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol phosphate biosynthetic process"}
{"concept_id": "C2246331", "aliases": ["inositol trisphosphate formation", "inositol trisphosphate synthesis", "inositol trisphosphate biosynthesis", "inositol trisphosphate anabolism", "IP3 biosynthetic process", "IP3 biosynthesis"], "types": ["T044"], "canonical_name": "inositol trisphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. [GOC:mah]"}
{"concept_id": "C2246332", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol trisphosphate biosynthetic process"}
{"concept_id": "C2246333", "aliases": ["regulation of IP3 biosynthetic process", "regulation of inositol trisphosphate formation", "regulation of inositol trisphosphate biosynthesis", "regulation of inositol trisphosphate synthesis", "regulation of inositol trisphosphate anabolism", "regulation of IP3 biosynthesis"], "types": ["T040"], "canonical_name": "regulation of inositol trisphosphate biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate. [GOC:mah]"}
{"concept_id": "C2246334", "aliases": [], "types": ["T040"], "canonical_name": "regulation of myo-inositol trisphosphate biosynthesis"}
{"concept_id": "C2246335", "aliases": [], "types": ["T040"], "canonical_name": "regulation of myo-inositol trisphosphate biosynthetic process"}
{"concept_id": "C2246336", "aliases": ["negative regulation of inositol trisphosphate biosynthesis", "negative regulation of IP3 biosynthetic process", "negative regulation of inositol trisphosphate anabolism", "negative regulation of inositol trisphosphate synthesis", "negative regulation of IP3 biosynthesis", "negative regulation of inositol trisphosphate formation"], "types": ["T040"], "canonical_name": "negative regulation of inositol trisphosphate biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate. [GOC:mah]"}
{"concept_id": "C2246337", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of myo-inositol trisphosphate biosynthesis"}
{"concept_id": "C2246338", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of myo-inositol trisphosphate biosynthetic process"}
{"concept_id": "C2246339", "aliases": ["positive regulation of inositol trisphosphate anabolism", "positive regulation of IP3 biosynthetic process", "positive regulation of IP3 biosynthesis", "positive regulation of inositol trisphosphate synthesis", "positive regulation of inositol trisphosphate biosynthesis", "positive regulation of inositol trisphosphate formation"], "types": ["T044"], "canonical_name": "positive regulation of inositol trisphosphate biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate. [GOC:mah]"}
{"concept_id": "C2246340", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of myo-inositol trisphosphate biosynthesis"}
{"concept_id": "C2246341", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of myo-inositol trisphosphate biosynthetic process"}
{"concept_id": "C2246342", "aliases": ["collagen metabolism"], "types": ["T044"], "canonical_name": "collagen metabolic process", "definition": "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2246343", "aliases": ["collagen anabolism", "collagen synthesis", "collagen biosynthesis", "collagen formation"], "types": ["T044"], "canonical_name": "collagen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2246344", "aliases": ["regulation of collagen formation", "regulation of collagen synthesis", "regulation of collagen anabolism", "regulation of collagen biosynthesis"], "types": ["T043"], "canonical_name": "regulation of collagen biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:mah]"}
{"concept_id": "C2246345", "aliases": ["negative regulation of collagen anabolism", "negative regulation of collagen biosynthesis", "negative regulation of collagen synthesis", "negative regulation of collagen formation"], "types": ["T043"], "canonical_name": "negative regulation of collagen biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:mah]"}
{"concept_id": "C2246346", "aliases": ["positive regulation of collagen formation", "positive regulation of collagen biosynthesis", "positive regulation of collagen anabolism", "positive regulation of collagen synthesis"], "types": ["T043"], "canonical_name": "positive regulation of collagen biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:mah]"}
{"concept_id": "C2246347", "aliases": ["positive regulation of RNA elongation from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "positive regulation of transcription elongation from RNA polymerase II promoter", "definition": "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C2246349", "aliases": ["MP1-p14 scaffolding complex", "endosomal adaptor complex location", "MP1-p14 scaffolding complex location", "endosomal adaptor complex", "endosomal scaffold complex location"], "types": ["T026"], "canonical_name": "endosomal scaffold complex", "definition": "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling. [PMID:15263099, PMID:16227978, PMID:17496910]"}
{"concept_id": "C2246350", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament-based process", "definition": "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. [GOC:mah]"}
{"concept_id": "C2246351", "aliases": [], "types": ["T040"], "canonical_name": "regulation of muscle filament sliding", "definition": "Any process that modulates the frequency, rate or extent of muscle filament sliding. [GOC:ecd]"}
{"concept_id": "C2246352", "aliases": [], "types": ["T039"], "canonical_name": "regulation of muscle filament sliding speed", "definition": "Any process that modulates the velocity of muscle filament sliding. [GOC:dph, GOC:ecd, GOC:tb]"}
{"concept_id": "C2246353", "aliases": ["amino acid efflux", "amino acid export"], "types": ["T043"], "canonical_name": "amino acid export across plasma membrane", "definition": "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:jl]"}
{"concept_id": "C2246354", "aliases": ["vacuolar amino acid export", "amino acid efflux from vacuole"], "types": ["T043"], "canonical_name": "amino acid transmembrane export from vacuole", "definition": "The directed movement of amino acids out of the vacuole, across the vacuolar membrane. [GOC:mah]"}
{"concept_id": "C2246355", "aliases": ["vacuolar amino acid import"], "types": ["T043"], "canonical_name": "amino acid transmembrane import into vacuole", "definition": "The directed movement of amino acids into the vacuole across the vacuolar membrane. [GOC:mah]"}
{"concept_id": "C2246356", "aliases": [], "types": ["T043"], "canonical_name": "release of matrix enzymes from mitochondria", "definition": "The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process. [GOC:mah, GOC:mtg_apoptosis, PMID:9843949]"}
{"concept_id": "C2246357", "aliases": [], "types": ["T043"], "canonical_name": "mAST release from mitochondria"}
{"concept_id": "C2246358", "aliases": [], "types": ["T043"], "canonical_name": "release of aspartate aminotransferase from mitochondria"}
{"concept_id": "C2246359", "aliases": [], "types": ["T044"], "canonical_name": "membrane insertase activity", "definition": "Binds transmembrane domain-containing proteins and mediates their integration into a membrane. [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]"}
{"concept_id": "C2246360", "aliases": ["insertion of proteins into membrane from the inner side"], "types": ["T043"], "canonical_name": "protein insertion into membrane from inner side", "definition": "The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side. [PMID:14739936, PMID:15473843]"}
{"concept_id": "C2246361", "aliases": ["protein insertion into mitochondrial inner membrane from matrix side", "insertion of proteins into the mitochondrial membrane from the inner side", "protein insertion into mitochondrial membrane from inner side"], "types": ["T043"], "canonical_name": "protein insertion into mitochondrial inner membrane from matrix", "definition": "The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix. [GOC:vw, PMID:12880202, PMID:15473843]"}
{"concept_id": "C2246362", "aliases": [], "types": ["T043"], "canonical_name": "keratinocyte activation", "definition": "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines. [GOC:mah, PMID:15737202]"}
{"concept_id": "C2246363", "aliases": ["mitochondrial NADH dehydrogenase complex (ubiquinone) assembly", "mitochondrial complex I assembly"], "types": ["T044"], "canonical_name": "mitochondrial respiratory chain complex I assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. [GOC:rph]"}
{"concept_id": "C2246364", "aliases": [], "types": ["T026"], "canonical_name": "myosin filament", "definition": "A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. [GOC:mah]"}
{"concept_id": "C2246365", "aliases": [], "types": ["T026"], "canonical_name": "myosin thick filament"}
{"concept_id": "C2246366", "aliases": ["kainate selective glutamate receptor complex location"], "types": ["T026"], "canonical_name": "kainate selective glutamate receptor complex", "definition": "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits. [GOC:bf, http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html, PMID:18655795]"}
{"concept_id": "C2246367", "aliases": ["cellular macromolecule complex disassembly"], "types": ["T043"], "canonical_name": "macromolecule complex disassembly"}
{"concept_id": "C2246368", "aliases": [], "types": ["T043"], "canonical_name": "protein-carbohydrate complex disassembly", "definition": "The disaggregation of a protein-carbohydrate complex into its constituent components. [GOC:mah]"}
{"concept_id": "C2246369", "aliases": ["DNA-protein complex disassembly"], "types": ["T043"], "canonical_name": "protein-DNA complex disassembly", "definition": "The disaggregation of a protein-DNA complex into its constituent components. [GOC:mah]"}
{"concept_id": "C2246370", "aliases": [], "types": ["T043"], "canonical_name": "protein-lipid complex disassembly", "definition": "The disaggregation of a protein-lipid complex into its constituent components. [GOC:mah]"}
{"concept_id": "C2246371", "aliases": ["protein-RNA complex disassembly", "RNA-protein complex disassembly", "RNP complex disassembly"], "types": ["T043"], "canonical_name": "ribonucleoprotein complex disassembly", "definition": "The disaggregation of a protein-RNA complex into its constituent components. [GOC:mah]"}
{"concept_id": "C2246372", "aliases": ["cellular structure morphogenesis"], "types": ["T040"], "canonical_name": "cellular component morphogenesis", "definition": "The process in which cellular structures, including whole cells or cell parts, are generated and organized. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2246373", "aliases": [], "types": ["T040"], "canonical_name": "cell part morphogenesis", "definition": "The process in which the anatomical structures of a cell part are generated and organized. [GOC:mah]"}
{"concept_id": "C2246374", "aliases": ["macromolecule complex location", "macromolecule complex", "protein containing complex", "macromolecular complex location", "protein-containing complex location", "protein containing complex location", "macromolecular complex"], "types": ["T026"], "canonical_name": "protein-containing complex", "definition": "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]"}
{"concept_id": "C2246375", "aliases": ["protein-carbohydrate complex location"], "types": ["T026"], "canonical_name": "protein-carbohydrate complex", "definition": "A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other. [GOC:mah]"}
{"concept_id": "C2246376", "aliases": ["DNA-protein complex", "protein-DNA complex location", "DNA-protein complex location"], "types": ["T026"], "canonical_name": "protein-DNA complex", "definition": "A macromolecular complex containing both protein and DNA molecules. [GOC:mah]"}
{"concept_id": "C2246377", "aliases": ["protein-lipid complex location"], "types": ["T026"], "canonical_name": "protein-lipid complex", "definition": "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. [GOC:mah]"}
{"concept_id": "C2246378", "aliases": ["regulation of chitin- and beta-glucan-containing cell wall biogenesis"], "types": ["T043"], "canonical_name": "regulation of fungal-type cell wall biogenesis", "definition": "Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2246379", "aliases": ["Bcl3-Bcl10 complex location"], "types": ["T026"], "canonical_name": "Bcl3-Bcl10 complex", "definition": "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus. [PMID:16280327]"}
{"concept_id": "C2246380", "aliases": ["FcR complex", "FcR complex location", "Fc-receptor complex location", "Fc receptor complex location", "Fc-receptor complex"], "types": ["T026"], "canonical_name": "Fc receptor complex", "definition": "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C2246381", "aliases": ["immunoglobulin receptor complex location"], "types": ["T026"], "canonical_name": "immunoglobulin receptor complex"}
{"concept_id": "C2246382", "aliases": ["Fc-epsilon receptor I complex location", "FceRI complex", "FceRI complex location"], "types": ["T026"], "canonical_name": "Fc-epsilon receptor I complex", "definition": "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C2246383", "aliases": ["IgE receptor complex location", "immunoglobulin E receptor complex location", "IgE receptor complex"], "types": ["T026"], "canonical_name": "immunoglobulin E receptor complex"}
{"concept_id": "C2246384", "aliases": ["Fc-alpha receptor I complex location", "FcaRI complex", "FcaRI complex location"], "types": ["T026"], "canonical_name": "Fc-alpha receptor I complex", "definition": "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA. [GOC:add, ISBN:0781735149, PMID:12524384]"}
{"concept_id": "C2246385", "aliases": ["IgA receptor complex", "immunoglobulin A receptor complex location", "IgA receptor complex location"], "types": ["T026"], "canonical_name": "immunoglobulin A receptor complex"}
{"concept_id": "C2246386", "aliases": ["FcgRI complex", "Fc-gamma receptor I complex location", "FcgRI complex location"], "types": ["T026"], "canonical_name": "Fc-gamma receptor I complex", "definition": "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG. [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532]"}
{"concept_id": "C2246387", "aliases": ["immunoglobulin G receptor complex", "IgG receptor complex", "immunoglobulin G receptor complex location", "IgG receptor complex location"], "types": ["T026"], "canonical_name": "immunoglobulin G receptor complex"}
{"concept_id": "C2246388", "aliases": ["FcgRIII complex location", "FcgRIII complex", "Fc-gamma receptor III complex location"], "types": ["T026"], "canonical_name": "Fc-gamma receptor III complex", "definition": "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG. [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532]"}
{"concept_id": "C2246389", "aliases": ["myocyte proliferation"], "types": ["T043"], "canonical_name": "muscle cell proliferation", "definition": "The expansion of a muscle cell population by cell division. [CL:0000187, GOC:mah]"}
{"concept_id": "C2246390", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mast cell activation", "definition": "Any process that modulates the frequency, rate, or extent of mast cell activation. [GOC:mah]"}
{"concept_id": "C2246391", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mast cell activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. [GOC:mah]"}
{"concept_id": "C2246392", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mast cell activation", "definition": "Any process that activates or increases the frequency, rate, or extent of mast cell activation. [GOC:mah]"}
{"concept_id": "C2246393", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mast cell activation during immune response"}
{"concept_id": "C2246394", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mast cell activation during immune response"}
{"concept_id": "C2246395", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mast cell activation during immune response"}
{"concept_id": "C2246396", "aliases": [], "types": ["T026"], "canonical_name": "nucleomorph", "definition": "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively. [PMID:16760254]"}
{"concept_id": "C2246397", "aliases": ["paranodal axoglial junction", "paranodal septate junction", "axoglial septate junction"], "types": ["T030"], "canonical_name": "paranodal junction", "definition": "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. [PMID:11395001, PMID:14630217]"}
{"concept_id": "C2246398", "aliases": [], "types": ["T026"], "canonical_name": "perinuclear theca", "definition": "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins. [PMID:17289678, PMID:8025156]"}
{"concept_id": "C2246399", "aliases": [], "types": ["T026"], "canonical_name": "porosome", "definition": "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles. [PMID:15090256, PMID:16563225]"}
{"concept_id": "C2246400", "aliases": ["tetrapyrrole metabolism"], "types": ["T044"], "canonical_name": "tetrapyrrole metabolic process", "definition": "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. [GOC:mah]"}
{"concept_id": "C2246401", "aliases": ["tetrapyrrole biosynthesis", "tetrapyrrole formation", "tetrapyrrole synthesis", "tetrapyrrole anabolism"], "types": ["T044"], "canonical_name": "tetrapyrrole biosynthetic process", "definition": "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. [GOC:mah]"}
{"concept_id": "C2246402", "aliases": ["tetrapyrrole breakdown", "tetrapyrrole degradation", "tetrapyrrole catabolism"], "types": ["T044"], "canonical_name": "tetrapyrrole catabolic process", "definition": "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. [GOC:mah]"}
{"concept_id": "C2246403", "aliases": [], "types": ["T026"], "canonical_name": "rhoptry membrane", "definition": "The lipid bilayer surrounding a rhoptry. [GOC:mah]"}
{"concept_id": "C2246404", "aliases": [], "types": ["T026"], "canonical_name": "sarcoplasmic reticulum membrane", "definition": "The lipid bilayer surrounding the sarcoplasmic reticulum. [GOC:rph]"}
{"concept_id": "C2246405", "aliases": [], "types": ["T026"], "canonical_name": "sarcoplasmic reticulum lumen", "definition": "The volume enclosed by the membranes of the sarcoplasmic reticulum. [GOC:rph]"}
{"concept_id": "C2246406", "aliases": [], "types": ["T044"], "canonical_name": "5-hydroxyvalerate dehydrogenase activity", "definition": "Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH. [GOC:mlg, PMID:12406764]"}
{"concept_id": "C2246407", "aliases": ["cyclopentanol metabolism"], "types": ["T044"], "canonical_name": "cyclopentanol metabolic process", "definition": "The chemical reactions and pathways involving cyclopentanol. [GOC:mlg, PMID:12406764]"}
{"concept_id": "C2246408", "aliases": ["cyclopentanol synthesis", "cyclopentanol formation", "cyclopentanol anabolism", "cyclopentanol biosynthesis"], "types": ["T044"], "canonical_name": "cyclopentanol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cyclopentanol. [GOC:mah, PMID:12406764]"}
{"concept_id": "C2246409", "aliases": ["cyclopentanol degradation", "cyclopentanol breakdown", "cyclopentanol catabolism"], "types": ["T044"], "canonical_name": "cyclopentanol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cyclopentanol. [GOC:mah, PMID:12406764]"}
{"concept_id": "C2246410", "aliases": [], "types": ["T043"], "canonical_name": "mast cell homeostasis", "definition": "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, PMID:11292031]"}
{"concept_id": "C2246411", "aliases": ["apoptosis of mast cells", "mast cell apoptosis"], "types": ["T043"], "canonical_name": "mast cell apoptotic process", "definition": "Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. [CL:0000097, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:12360215, PMID:16605130]"}
{"concept_id": "C2246412", "aliases": ["regulation of mast cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of mast cell apoptotic process", "definition": "Any process that modulates the frequency, rate, or extent of mast cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C2246414", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mast cell apoptosis"}
{"concept_id": "C2246416", "aliases": [], "types": ["T043"], "canonical_name": "activation of mast cell apoptosis"}
{"concept_id": "C2246417", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mast cell apoptosis"}
{"concept_id": "C2246419", "aliases": ["regulation of neutrophil apoptosis"], "types": ["T043"], "canonical_name": "regulation of neutrophil apoptotic process", "definition": "Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C2246421", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil apoptosis"}
{"concept_id": "C2246423", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil apoptosis"}
{"concept_id": "C2246424", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neutrophil apoptosis"}
{"concept_id": "C2246425", "aliases": ["regulation of myeloid cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of myeloid cell apoptotic process", "definition": "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C2246427", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myeloid cell apoptosis"}
{"concept_id": "C2246429", "aliases": [], "types": ["T043"], "canonical_name": "activation of myeloid cell apoptosis"}
{"concept_id": "C2246430", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of myeloid cell apoptosis"}
{"concept_id": "C2246431", "aliases": [], "types": ["T044"], "canonical_name": "dipyrromethane cofactor binding"}
{"concept_id": "C2246432", "aliases": ["macromolecule localisation"], "types": ["T039"], "canonical_name": "macromolecule localization", "definition": "Any process in which a macromolecule is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C2246433", "aliases": ["polysaccharide localisation"], "types": ["T039"], "canonical_name": "polysaccharide localization", "definition": "Any process in which a polysaccharide is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C2246434", "aliases": [], "types": ["T044"], "canonical_name": "bitter taste receptor activity", "definition": "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. [GOC:mah]"}
{"concept_id": "C2246435", "aliases": [], "types": ["T044"], "canonical_name": "salty taste receptor activity", "definition": "Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste. [GOC:mah]"}
{"concept_id": "C2246436", "aliases": [], "types": ["T044"], "canonical_name": "sour taste receptor activity", "definition": "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste. [GOC:mah]"}
{"concept_id": "C2246437", "aliases": [], "types": ["T044"], "canonical_name": "sweet taste receptor activity", "definition": "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste. [GOC:mah]"}
{"concept_id": "C2246438", "aliases": [], "types": ["T044"], "canonical_name": "umami taste receptor activity", "definition": "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates. [GOC:mah]"}
{"concept_id": "C2246439", "aliases": ["regulation of organelle organisation", "regulation of organelle organization and biogenesis"], "types": ["T043"], "canonical_name": "regulation of organelle organization", "definition": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. [GOC:mah]"}
{"concept_id": "C2246440", "aliases": ["regulation of chromosome organisation", "regulation of chromosome organization and biogenesis"], "types": ["T043"], "canonical_name": "regulation of chromosome organization", "definition": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. [GOC:mah]"}
{"concept_id": "C2246441", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sister chromatid segregation", "definition": "Any process that modulates the frequency, rate or extent of sister chromatid segregation. [GOC:mah]"}
{"concept_id": "C2246442", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of sister chromatid segregation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation. [GOC:mah]"}
{"concept_id": "C2246443", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic sister chromatid segregation", "definition": "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. [GOC:mah]"}
{"concept_id": "C2246444", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic sister chromatid segregation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis. [GOC:mah]"}
{"concept_id": "C2246445", "aliases": ["clavulanic acid metabolism"], "types": ["T044"], "canonical_name": "clavulanic acid metabolic process", "definition": "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. [GOC:mah]"}
{"concept_id": "C2246446", "aliases": ["clavulanic acid anabolism", "clavulanic acid formation", "clavulanic acid biosynthesis", "clavulanic acid synthesis"], "types": ["T044"], "canonical_name": "clavulanic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. [GOC:mah]"}
{"concept_id": "C2246447", "aliases": ["D-glutamine metabolism"], "types": ["T044"], "canonical_name": "D-glutamine metabolic process", "definition": "The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid. [GOC:jsg, GOC:mah]"}
{"concept_id": "C2246448", "aliases": ["D-glutamate metabolism"], "types": ["T044"], "canonical_name": "D-glutamate metabolic process", "definition": "The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid. [GOC:jsg, GOC:mah]"}
{"concept_id": "C2246449", "aliases": ["D-arginine metabolism"], "types": ["T044"], "canonical_name": "D-arginine metabolic process", "definition": "The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid. [GOC:jsg, GOC:mah]"}
{"concept_id": "C2246450", "aliases": ["D-ornithine metabolism"], "types": ["T044"], "canonical_name": "D-ornithine metabolic process", "definition": "The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid. [GOC:jsg, GOC:mah]"}
{"concept_id": "C2246452", "aliases": [], "types": ["T040"], "canonical_name": "directional locomotion", "definition": "Self-propelled movement of a cell or organism from one location to another along an axis. [GOC:mtg_MIT_16mar07]"}
{"concept_id": "C2246453", "aliases": [], "types": ["T043"], "canonical_name": "cellular pigmentation", "definition": "The deposition or aggregation of coloring matter in a cell. [GOC:mtg_MIT_16mar07]"}
{"concept_id": "C2246454", "aliases": [], "types": ["T042"], "canonical_name": "ocellus pigmentation", "definition": "The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates. [GOC:mtg_MIT_16mar07]"}
{"concept_id": "C2246455", "aliases": ["DNA recombinase mediator complex location"], "types": ["T026"], "canonical_name": "DNA recombinase mediator complex", "definition": "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange. [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992, PMID:32414915]"}
{"concept_id": "C2246456", "aliases": ["Rad55-Rad57 complex", "Rad55-Rad57 complex location", "Rhp55-Rhp57 complex location"], "types": ["T026"], "canonical_name": "Rhp55-Rhp57 complex", "definition": "A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces). [GOC:mah, GOC:vw]"}
{"concept_id": "C2246457", "aliases": ["BCDX2 complex", "Rad51B-Rad51C-Rad51D-XRCC2 complex location", "BCDX2 complex location"], "types": ["T026"], "canonical_name": "Rad51B-Rad51C-Rad51D-XRCC2 complex", "definition": "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof. [GOC:mah, PMID:16093548, PMID:17114795]"}
{"concept_id": "C2246458", "aliases": ["DX2 complex location", "DX2 complex", "XRCC2-RAD51D complex location"], "types": ["T026"], "canonical_name": "XRCC2-RAD51D complex", "definition": "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast. [GOC:mah, GOC:vw, PMID:16093548]"}
{"concept_id": "C2246459", "aliases": ["CX3 complex", "Rad51C-XRCC3 complex location", "CX3 complex location"], "types": ["T026"], "canonical_name": "Rad51C-XRCC3 complex", "definition": "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof. [GOC:mah, PMID:16093548, PMID:17114795]"}
{"concept_id": "C2246460", "aliases": ["BC complex location", "BC complex", "Rad51B-Rad51C complex location"], "types": ["T026"], "canonical_name": "Rad51B-Rad51C complex", "definition": "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof. [GOC:mah, PMID:16093548, PMID:17114795]"}
{"concept_id": "C2246461", "aliases": ["macrolide metabolism"], "types": ["T044"], "canonical_name": "macrolide metabolic process", "definition": "The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria. [ISBN:0198506732, PMID:17298179]"}
{"concept_id": "C2246462", "aliases": ["macrolide formation", "macrolide biosynthesis", "macrolide anabolism", "macrolide synthesis"], "types": ["T044"], "canonical_name": "macrolide biosynthetic process", "definition": "The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria. [ISBN:0198506732, PMID:17298179]"}
{"concept_id": "C2246463", "aliases": ["ansamycin metabolism"], "types": ["T044"], "canonical_name": "ansamycin metabolic process", "definition": "The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity. [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm]"}
{"concept_id": "C2246464", "aliases": ["ansamycin biosynthesis", "ansamycin formation", "ansamycin synthesis", "ansamycin anabolism"], "types": ["T044"], "canonical_name": "ansamycin biosynthetic process", "definition": "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity. [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm]"}
{"concept_id": "C2246465", "aliases": ["vancomycin metabolism"], "types": ["T044"], "canonical_name": "vancomycin metabolic process", "definition": "The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria. [GOC:mah]"}
{"concept_id": "C2246466", "aliases": ["vancomycin formation", "vancomycin synthesis", "vancomycin anabolism", "vancomycin biosynthesis"], "types": ["T044"], "canonical_name": "vancomycin biosynthetic process", "definition": "The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria. [GOC:mah]"}
{"concept_id": "C2246467", "aliases": ["pinene metabolism"], "types": ["T044"], "canonical_name": "pinene metabolic process", "definition": "The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane. [GOC:mah, PMID:12623076]"}
{"concept_id": "C2246468", "aliases": ["pinene breakdown", "pinene catabolism", "pinene degradation"], "types": ["T044"], "canonical_name": "pinene catabolic process", "definition": "The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane. [GOC:mah, PMID:11452597]"}
{"concept_id": "C2246469", "aliases": ["isoquinoline alkaloid biosynthetic process", "isoquinoline alkaloid anabolism", "isoquinoline alkaloid formation", "isoquinoline alkaloid biosynthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html]", "canonical_name": "isoquinoline alkaloid synthesis"}
{"concept_id": "C2246470", "aliases": [], "types": ["T044"], "canonical_name": "ipecac alkaloid biosynthesis"}
{"concept_id": "C2246471", "aliases": ["isoquinoline alkaloid metabolism"], "types": ["T044"], "canonical_name": "isoquinoline alkaloid metabolic process", "definition": "The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html]"}
{"concept_id": "C2246472", "aliases": [], "types": ["T044"], "canonical_name": "ipecac alkaloid metabolism"}
{"concept_id": "C2246474", "aliases": [], "types": ["T043"], "canonical_name": "extrathymic T cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C2246475", "aliases": [], "types": ["T043"], "canonical_name": "immature T cell proliferation", "definition": "The expansion of an immature T cell population by cell division. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C2246476", "aliases": ["thymocyte proliferation", "thymic T cell proliferation", "thymocyte cell proliferation"], "types": ["T043"], "canonical_name": "immature T cell proliferation in thymus", "definition": "The expansion of an immature T cell population by cell division in the thymus. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C2246477", "aliases": ["regulation of thymic T cell differentiation", "regulation of thymocyte differentiation", "regulation of thymocyte cell differentiation"], "types": ["T043"], "canonical_name": "regulation of T cell differentiation in thymus", "definition": "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus. [GOC:add, GOC:mah]"}
{"concept_id": "C2246478", "aliases": [], "types": ["T043"], "canonical_name": "regulation of extrathymic T cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation. [GOC:add, GOC:mah]"}
{"concept_id": "C2246479", "aliases": [], "types": ["T043"], "canonical_name": "regulation of immature T cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of immature T cell proliferation. [GOC:add, GOC:mah]"}
{"concept_id": "C2246480", "aliases": ["regulation of thymocyte cell proliferation", "regulation of thymocyte proliferation", "regulation of thymic T cell proliferation"], "types": ["T043"], "canonical_name": "regulation of immature T cell proliferation in thymus", "definition": "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus. [GOC:add, GOC:mah]"}
{"concept_id": "C2246481", "aliases": ["negative regulation of thymocyte differentiation", "negative regulation of thymocyte cell differentiation", "negative regulation of thymic T cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of T cell differentiation in thymus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus. [GOC:add, GOC:mah]"}
{"concept_id": "C2246482", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of extrathymic T cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation. [GOC:add, GOC:mah]"}
{"concept_id": "C2246483", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of immature T cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation. [GOC:add, GOC:mah]"}
{"concept_id": "C2246484", "aliases": ["negative regulation of thymocyte cell proliferation", "negative regulation of thymic T cell proliferation", "negative regulation of thymocyte proliferation"], "types": ["T043"], "canonical_name": "negative regulation of immature T cell proliferation in thymus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus. [GOC:add, GOC:mah]"}
{"concept_id": "C2246485", "aliases": ["positive regulation of thymic T cell differentiation", "positive regulation of thymocyte cell differentiation", "positive regulation of thymocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of T cell differentiation in thymus", "definition": "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. [GOC:add, GOC:mah]"}
{"concept_id": "C2246486", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of extrathymic T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation. [GOC:add, GOC:mah]"}
{"concept_id": "C2246487", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of immature T cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation. [GOC:add, GOC:mah]"}
{"concept_id": "C2246488", "aliases": ["positive regulation of thymocyte cell proliferation", "positive regulation of thymocyte proliferation", "positive regulation of thymic T cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of immature T cell proliferation in thymus", "definition": "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus. [GOC:add, GOC:mah]"}
{"concept_id": "C2246489", "aliases": ["PAT activity", "YgjG", "putrescine-alpha-ketoglutarate transaminase activity", "putrescine:2-oxoglutarate aminotransferase activity", "putrescine aminotransferase activity", "putrescine:alpha-ketoglutarate aminotransferase activity", "putrescine transaminase activity"], "types": ["T044"], "canonical_name": "butane-1,4-diamine:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. [EC:2.6.1.82, GOC:mlg, RHEA:12268]"}
{"concept_id": "C2246490", "aliases": ["aleurone body"], "types": ["T026"], "canonical_name": "aleurone grain", "definition": "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes. [PMID:22452734, Wikipedia:Aleurone]"}
{"concept_id": "C2246491", "aliases": [], "types": ["T026"], "canonical_name": "amyloplast envelope", "definition": "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. [GOC:mah]"}
{"concept_id": "C2246492", "aliases": [], "types": ["T026"], "canonical_name": "amyloplast membrane", "definition": "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope. [GOC:ecd]"}
{"concept_id": "C2246493", "aliases": [], "types": ["T026"], "canonical_name": "amyloplast inner membrane", "definition": "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma. [GOC:ecd]"}
{"concept_id": "C2246494", "aliases": [], "types": ["T026"], "canonical_name": "attachment organelle", "definition": "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division. [PMID:11325545, PMID:12003948]"}
{"concept_id": "C2246495", "aliases": ["NuA3 histone acetyltransferase complex location"], "types": ["T026"], "canonical_name": "NuA3 histone acetyltransferase complex", "definition": "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p. [PMID:10817755, PMID:17157260]"}
{"concept_id": "C2246496", "aliases": ["cellular bud plasma membrane"], "types": ["T026"], "canonical_name": "cellular bud membrane", "definition": "The portion of the plasma membrane surrounding a cellular bud. [GOC:mah]"}
{"concept_id": "C2246497", "aliases": [], "types": ["T026"], "canonical_name": "acidocalcisome membrane", "definition": "The lipid bilayer surrounding an acidocalcisome. [GOC:ecd, PMID:11378195]"}
{"concept_id": "C2246498", "aliases": ["type VI protein secretion system", "protein secretion by the type VI protein secretion system", "protein secretion by the T6SS"], "types": ["T043"], "canonical_name": "protein secretion by the type VI secretion system", "definition": "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence. [GOC:mlg, PMID:16432199, PMID:16763151]"}
{"concept_id": "C2246499", "aliases": ["type VI protein secretion system complex location", "T6SS complex location", "T6SS complex"], "types": ["T026"], "canonical_name": "type VI protein secretion system complex", "definition": "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. [GOC:mlg, PMID:16432199, PMID:16763151]"}
{"concept_id": "C2246500", "aliases": ["chlorosome membrane"], "types": ["T026"], "canonical_name": "chlorosome envelope", "definition": "The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome. [PMID:14507718, PMID:14729689, PMID:17303128]"}
{"concept_id": "C2246501", "aliases": ["cis Golgi network membrane"], "types": ["T026"], "canonical_name": "cis-Golgi network membrane", "definition": "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network. [GOC:mah]"}
{"concept_id": "C2246502", "aliases": [], "types": ["T026"], "canonical_name": "Golgi cis face membrane"}
{"concept_id": "C2246503", "aliases": ["cytoplasm to vacuole targeting vesicle", "cytoplasm-to-vacuole targeting vesicle"], "types": ["T026"], "canonical_name": "Cvt vesicle", "definition": "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p). [GOC:rb, PMID:15138258]"}
{"concept_id": "C2246504", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial respiratory chain complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. [GOC:mah]"}
{"concept_id": "C2246506", "aliases": [], "types": ["T043"], "canonical_name": "cortical resistance"}
{"concept_id": "C2246507", "aliases": ["cytoplasm to vacuole targeting vesicle membrane", "cytoplasm-to-vacuole targeting vesicle membrane"], "types": ["T026"], "canonical_name": "Cvt vesicle membrane", "definition": "Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway. [GOC:ecd, PMID:20065092]"}
{"concept_id": "C2246508", "aliases": [], "types": ["T026"], "canonical_name": "attachment organelle membrane", "definition": "The lipid bilayer surrounding an attachment organelle. This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane. [GOC:ecd]"}
{"concept_id": "C2246509", "aliases": [], "types": ["T026"], "canonical_name": "cyanelle envelope", "definition": "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space. [GOC:mah]"}
{"concept_id": "C2246510", "aliases": [], "types": ["T026"], "canonical_name": "cyanelle membrane", "definition": "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope. [GOC:ecd]"}
{"concept_id": "C2246511", "aliases": [], "types": ["T026"], "canonical_name": "cyanelle thylakoid lumen", "definition": "The volume enclosed by a cyanelle thylakoid membrane. [GOC:mah]"}
{"concept_id": "C2246512", "aliases": [], "types": ["T026"], "canonical_name": "cyanelle thylakoid membrane", "definition": "The lipid bilayer membrane of any thylakoid within a cyanelle. [GOC:mah]"}
{"concept_id": "C2246513", "aliases": ["ER-Golgi intermediate compartment membrane"], "types": ["T026"], "canonical_name": "endoplasmic reticulum-Golgi intermediate compartment membrane", "definition": "The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. [GOC:mah, GOC:pr, PMID:16723730]"}
{"concept_id": "C2246514", "aliases": [], "types": ["T026"], "canonical_name": "esterosome", "definition": "A vesicle filled with crystalline protein that shows sequence similarities with various esterases. [GOC:ecd, PMID:2307702]"}
{"concept_id": "C2246515", "aliases": [], "types": ["T026"], "canonical_name": "esterosome membrane", "definition": "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes. [GOC:ecd, PMID:2307702]"}
{"concept_id": "C2246516", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of RNA splicing", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. [GOC:mah]"}
{"concept_id": "C2246517", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of RNA splicing", "definition": "Any process that activates or increases the frequency, rate or extent of RNA splicing. [GOC:mah]"}
{"concept_id": "C2246518", "aliases": ["regulation of purine nucleotide breakdown", "regulation of purine nucleotide degradation", "regulation of purine nucleotide catabolism"], "types": ["T045"], "canonical_name": "regulation of purine nucleotide catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides. [GOC:mah]"}
{"concept_id": "C2246519", "aliases": ["negative regulation of purine nucleotide breakdown", "negative regulation of purine nucleotide degradation", "negative regulation of purine nucleotide catabolism"], "types": ["T044"], "canonical_name": "negative regulation of purine nucleotide catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides. [GOC:mah]"}
{"concept_id": "C2246520", "aliases": ["positive regulation of purine nucleotide breakdown", "positive regulation of purine nucleotide degradation", "positive regulation of purine nucleotide catabolism"], "types": ["T044"], "canonical_name": "positive regulation of purine nucleotide catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides. [GOC:mah]"}
{"concept_id": "C2246524", "aliases": [], "types": ["T040"], "canonical_name": "regulation of histone phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. [GOC:mah]"}
{"concept_id": "C2246525", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of histone phosphorylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. [GOC:mah]"}
{"concept_id": "C2246526", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of histone phosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. [GOC:mah]"}
{"concept_id": "C2246527", "aliases": [], "types": ["T044"], "definition": "Binding to an acetylcholine receptor. [GOC:mah]", "canonical_name": "acetylcholine receptor binding"}
{"concept_id": "C2246528", "aliases": [], "types": ["T040"], "canonical_name": "regulation of glucokinase activity", "definition": "Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. [GOC:mah]"}
{"concept_id": "C2246529", "aliases": [], "types": ["T044"], "canonical_name": "glucokinase regulator"}
{"concept_id": "C2246530", "aliases": ["down-regulation of glucokinase activity", "downregulation of glucokinase activity", "down regulation of glucokinase activity"], "types": ["T044"], "canonical_name": "negative regulation of glucokinase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. [GOC:mah]"}
{"concept_id": "C2246531", "aliases": [], "types": ["T044"], "canonical_name": "glucokinase inhibitor"}
{"concept_id": "C2246532", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of glucokinase activity"}
{"concept_id": "C2246533", "aliases": ["up-regulation of glucokinase activity", "upregulation of glucokinase activity", "up regulation of glucokinase activity"], "types": ["T040"], "canonical_name": "positive regulation of glucokinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. [GOC:mah]"}
{"concept_id": "C2246534", "aliases": [], "types": ["T044"], "canonical_name": "glucokinase activator"}
{"concept_id": "C2246535", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of glucokinase activity"}
{"concept_id": "C2246536", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin activating enzyme binding", "definition": "Binding to a ubiquitin activating enzyme, any of the E1 proteins. [GOC:mah]"}
{"concept_id": "C2246537", "aliases": [], "types": ["T040"], "canonical_name": "regulation of peptidyl-serine phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]"}
{"concept_id": "C2246538", "aliases": [], "types": ["T044"], "canonical_name": "serine phosphorylation of STAT3 protein"}
{"concept_id": "C2246539", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of peptidyl-serine phosphorylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]"}
{"concept_id": "C2246540", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of peptidyl-serine phosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]"}
{"concept_id": "C2246541", "aliases": [], "types": ["T044"], "canonical_name": "regulation of peptidyl-serine phosphorylation of STAT protein", "definition": "Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:mah]"}
{"concept_id": "C2246542", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of peptidyl-serine phosphorylation of STAT protein", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:mah]"}
{"concept_id": "C2246543", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of peptidyl-serine phosphorylation of STAT protein", "definition": "Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:mah]"}
{"concept_id": "C2246544", "aliases": [], "types": ["T044"], "canonical_name": "progesterone receptor binding"}
{"concept_id": "C2246545", "aliases": ["regulation of steroid hormone receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of steroid hormone receptor signaling pathway"}
{"concept_id": "C2246546", "aliases": ["negative regulation of steroid hormone receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of steroid hormone receptor signaling pathway"}
{"concept_id": "C2246547", "aliases": ["positive regulation of steroid hormone receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of steroid hormone receptor signaling pathway"}
{"concept_id": "C2246548", "aliases": ["regulation of estrogen receptor signaling pathway", "regulation of estrogen receptor signalling pathway"], "types": ["T040"], "canonical_name": "regulation of intracellular estrogen receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C2246549", "aliases": ["negative regulation of estrogen receptor signalling pathway", "negative regulation of estrogen receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of intracellular estrogen receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C2246550", "aliases": ["positive regulation of estrogen receptor signalling pathway"], "types": ["T040"], "canonical_name": "positive regulation of estrogen receptor signaling pathway"}
{"concept_id": "C2246551", "aliases": [], "types": ["T044"], "canonical_name": "FFAT motif binding", "definition": "Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family. [PMID:12727870, PMID:15455074, PMID:16004875]"}
{"concept_id": "C2246552", "aliases": [], "types": ["T026"], "canonical_name": "cytoskeletal calyx", "definition": "A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins. [PMID:12243744, PMID:9184090]"}
{"concept_id": "C2246553", "aliases": ["immunoglobulin V-J joining", "immunoglobulin V(D)J joining", "immunoglobulin V-D-J joining", "immunoglobulin V-D-J recombination", "immunoglobulin V-J recombination", "immunoglobulin V(D)J recombination"], "types": ["T045"], "definition": "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined. [GOC:add, ISBN:0781735149]", "canonical_name": "immunoglobulin heavy chain V-D-J recombination"}
{"concept_id": "C2246554", "aliases": ["T cell receptor V-J joining", "T cell receptor V-J recombination", "T cell receptor V(D)J joining", "T cell receptor V-D-J joining", "TCR V(D)J recombination", "T-cell receptor V(D)J recombination", "T cell receptor V-D-J recombination"], "types": ["T045"], "canonical_name": "T cell receptor V(D)J recombination", "definition": "The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). [GOC:add, ISBN:0781700221]"}
{"concept_id": "C2246557", "aliases": [], "types": ["T043"], "canonical_name": "oligogalacturonide transport", "definition": "The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mlg]"}
{"concept_id": "C2246558", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intracellular protein transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. [GOC:mah]"}
{"concept_id": "C2246562", "aliases": ["MAPKKKK binding"], "types": ["T044"], "canonical_name": "mitogen-activated protein kinase kinase kinase kinase binding", "definition": "Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase. [GOC:mah]"}
{"concept_id": "C2246563", "aliases": [], "types": ["T026"], "canonical_name": "melanosome membrane", "definition": "The lipid bilayer surrounding a melanosome. [GOC:mah]"}
{"concept_id": "C2246564", "aliases": [], "types": ["T026"], "canonical_name": "microneme membrane", "definition": "The lipid bilayer surrounding a microneme. [GOC:mah]"}
{"concept_id": "C2246565", "aliases": ["GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity", "GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase activity", "GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity"], "types": ["T044"], "canonical_name": "initiation-specific alpha-1,6-mannosyltransferase activity"}
{"concept_id": "C2246566", "aliases": [], "types": ["T026"], "canonical_name": "interphotoreceptor matrix", "definition": "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance. [http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html, PMID:1862095, PMID:2194288]"}
{"concept_id": "C2246567", "aliases": [], "types": ["T026"], "canonical_name": "hyaline layer", "definition": "A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms. [http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html, PMID:1721506, PMID:9473317]"}
{"concept_id": "C2246568", "aliases": ["argonaute siRNA chaperone complex location", "ARC complex location", "ARC complex"], "types": ["T026"], "definition": "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA. [GOC:vw, PMID:17310250]", "canonical_name": "argonaute siRNA chaperone complex"}
{"concept_id": "C2246570", "aliases": [], "types": ["T045"], "canonical_name": "histone H3-K9 demethylation", "definition": "The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone. [GOC:mah]"}
{"concept_id": "C2246573", "aliases": ["gas vesicle wall"], "types": ["T026"], "canonical_name": "gas vesicle shell", "definition": "The proteinaceous structure surrounding a gas vesicle. [GOC:ecd]"}
{"concept_id": "C2246574", "aliases": [], "types": ["T026"], "canonical_name": "gas vesicle membrane"}
{"concept_id": "C2246575", "aliases": ["calcineurin-NFAT signalling pathway"], "types": ["T043"], "canonical_name": "calcineurin-NFAT signaling pathway"}
{"concept_id": "C2246576", "aliases": ["chloroplast proton-transporting ATP synthase complex location, catalytic core CF(1)", "chloroplast proton-transporting F-type ATPase complex location, catalytic core CF(1)", "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)"], "types": ["T026"], "canonical_name": "chloroplast proton-transporting ATP synthase complex, catalytic core CF(1)", "definition": "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits. [GOC:mah, GOC:pj, PMID:11032839]"}
{"concept_id": "C2246577", "aliases": ["chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)", "chloroplast proton-transporting F-type ATPase complex location, coupling factor CF(o)", "chloroplast proton-transporting ATP synthase complex location, coupling factor CF(o)", "chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)", "chloroplast proton-transporting ATP synthase complex location, coupling factor CF(0)"], "types": ["T026"], "canonical_name": "chloroplast proton-transporting ATP synthase complex, coupling factor CF(o)", "definition": "All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins. [GOC:mah]"}
{"concept_id": "C2246578", "aliases": ["hydrogen-translocating V-type ATPase complex location", "proton-transporting V-type ATPase complex location", "hydrogen-translocating V-type ATPase complex"], "types": ["T026"], "canonical_name": "proton-transporting V-type ATPase complex", "definition": "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. [GOC:mah, ISBN:0716743663, PMID:16449553]"}
{"concept_id": "C2246579", "aliases": ["proton-transporting two-sector ATPase complex location, proton-transporting domain"], "types": ["T026"], "canonical_name": "proton-transporting two-sector ATPase complex, proton-transporting domain", "definition": "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. [GOC:mah, PMID:10838056]"}
{"concept_id": "C2246580", "aliases": ["proton-transporting two-sector ATPase complex location, catalytic domain"], "types": ["T026"], "canonical_name": "proton-transporting two-sector ATPase complex, catalytic domain", "definition": "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. [GOC:mah, PMID:10838056]"}
{"concept_id": "C2246581", "aliases": [], "types": ["T026"], "canonical_name": "proton-transporting V-type ATPase, V0 domain", "definition": "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. [GOC:mah, ISBN:0716743663, PMID:16449553]"}
{"concept_id": "C2246582", "aliases": [], "types": ["T026"], "canonical_name": "proton-transporting V-type ATPase, V1 domain", "definition": "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. [GOC:mah, ISBN:0716743663, PMID:16449553]"}
{"concept_id": "C2246583", "aliases": ["plasma membrane hydrogen ion-transporting ATPase", "plasma membrane proton-transporting V-type ATPase complex location"], "types": ["T026"], "canonical_name": "plasma membrane proton-transporting V-type ATPase complex", "definition": "A proton-transporting two-sector ATPase complex found in the plasma membrane. [GOC:mah]"}
{"concept_id": "C2246584", "aliases": [], "types": ["T045"], "canonical_name": "regulation of histone ubiquitination", "definition": "Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein. [GOC:mah]"}
{"concept_id": "C2246585", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of histone ubiquitination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of a ubiquitin group to a histone protein. [GOC:mah]"}
{"concept_id": "C2246586", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of histone ubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein. [GOC:mah]"}
{"concept_id": "C2246587", "aliases": ["dolichyl-phosphate beta-D-mannosyltransferase complex", "dolichol-phosphate-mannose synthase complex location", "DPM synthase complex location", "DPM synthase complex", "dolichyl-phosphate beta-D-mannosyltransferase complex location"], "types": ["T026"], "canonical_name": "dolichol-phosphate-mannose synthase complex", "definition": "A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively. [PMID:10835346]"}
{"concept_id": "C2246588", "aliases": ["CAF-1 complex location", "chromatin assembly factor 1 complex", "chromatin assembly factor 1 complex location"], "types": ["T026"], "definition": "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48. [PMID:17065558, PMID:17083276]", "canonical_name": "CAF-1 complex"}
{"concept_id": "C2246590", "aliases": [], "types": ["T043"], "canonical_name": "response to vitamin A", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. [GOC:sl]"}
{"concept_id": "C2246591", "aliases": [], "types": ["T043"], "canonical_name": "response to retinol"}
{"concept_id": "C2246592", "aliases": [], "types": ["T044"], "canonical_name": "solanapyrone synthase activity", "definition": "Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A. [GOC:cb, PMID:9659400]"}
{"concept_id": "C2246593", "aliases": [], "types": ["T044"], "canonical_name": "macrophomate synthase activity", "definition": "Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate. [GOC:cb, PMID:10984474]"}
{"concept_id": "C2246594", "aliases": ["calcium/calmodulin-dependent protein phosphatase activity", "calcium- and calmodulin-dependent protein phosphatase activity"], "types": ["T044"], "canonical_name": "calmodulin-dependent protein phosphatase activity", "definition": "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. [GOC:mah, PMID:15359118]"}
{"concept_id": "C2246595", "aliases": [], "types": ["T044"], "canonical_name": "Ca2+/CaM-dependent protein phosphatase activity"}
{"concept_id": "C2246596", "aliases": ["SAPHIRE complex location", "Swm complex location", "Lsd1/2 complex location", "SAPHIRE complex", "Swm complex"], "types": ["T026"], "canonical_name": "Lsd1/2 complex", "definition": "A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast. [GOC:vw, PMID:17371846, PMID:17434129, PMID:17440621]"}
{"concept_id": "C2246597", "aliases": ["Swm1/2 complex location"], "types": ["T026"], "canonical_name": "Swm1/2 complex"}
{"concept_id": "C2246598", "aliases": [], "types": ["T043"], "canonical_name": "response to hydroperoxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. [GOC:mah]"}
{"concept_id": "C2246599", "aliases": [], "types": ["T043"], "canonical_name": "response to alkyl hydroperoxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group. [GOC:mah]"}
{"concept_id": "C2246600", "aliases": [], "types": ["T043"], "canonical_name": "response to vitamin E", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. [GOC:sl]"}
{"concept_id": "C2246601", "aliases": [], "types": ["T043"], "canonical_name": "response to DL-alpha-tocopherol acetate"}
{"concept_id": "C2246602", "aliases": [], "types": ["T043"], "canonical_name": "response to DL-alpha-tocopheryl acetate"}
{"concept_id": "C2246603", "aliases": [], "types": ["T043"], "canonical_name": "response to O-Acetyl-alpha-tocopherol"}
{"concept_id": "C2246604", "aliases": ["response to adenosine triphosphate", "response to adenosine 5'-triphosphate"], "types": ["T043"], "canonical_name": "response to ATP", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:sl]"}
{"concept_id": "C2246606", "aliases": ["diphosphoinositol-pentakisphosphate 5-kinase activity", "IP7 5-kinase activity"], "types": ["T044"], "canonical_name": "inositol heptakisphosphate 5-kinase activity", "definition": "Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate. [PMID:17412958]"}
{"concept_id": "C2246607", "aliases": ["1,4-alpha-glucan synthase activity"], "types": ["T044"], "canonical_name": "alpha-1,4-glucan synthase activity", "definition": "Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP. [PMID:17472966]"}
{"concept_id": "C2246608", "aliases": ["DNA helicase complex location"], "types": ["T026"], "canonical_name": "DNA helicase complex", "definition": "A protein complex that possesses DNA helicase activity. [GOC:mah]"}
{"concept_id": "C2246609", "aliases": ["DNA helicase A complex location"], "types": ["T026"], "canonical_name": "DNA helicase A complex", "definition": "A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction. [PMID:9341218]"}
{"concept_id": "C2246610", "aliases": ["RNase P RNA binding"], "types": ["T045"], "canonical_name": "ribonuclease P RNA binding", "definition": "Binding to RNA subunit of ribonuclease P. [GOC:pg, PMID:11455963]"}
{"concept_id": "C2246612", "aliases": ["cytokinesis after meiosis"], "types": ["T043"], "canonical_name": "meiotic cytokinesis", "definition": "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells. [GOC:mtg_cell_cycle]"}
{"concept_id": "C2246613", "aliases": ["beta-1,4-GalNAc transferase activity"], "types": ["T044"], "canonical_name": "beta-1,4-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage. [GOC:mah]"}
{"concept_id": "C2246614", "aliases": ["UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity"], "types": ["T044"], "canonical_name": "UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide. [GOC:mah, PMID:12678917, PMID:16024623]"}
{"concept_id": "C2246615", "aliases": [], "types": ["T044"], "canonical_name": "Sda beta 1,4GalNAc transferase"}
{"concept_id": "C2246616", "aliases": ["tumor necrosis factor-mediated signalling pathway"], "types": ["T043"], "canonical_name": "tumor necrosis factor-mediated signaling pathway", "definition": "The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]"}
{"concept_id": "C2246617", "aliases": [], "types": ["T043"], "canonical_name": "adipocytokine signaling pathway"}
{"concept_id": "C2246618", "aliases": ["leptin-mediated signalling pathway"], "types": ["T043"], "canonical_name": "leptin-mediated signaling pathway", "definition": "The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. [GOC:mah, GOC:signaling, GOC:yaf]"}
{"concept_id": "C2246619", "aliases": ["adiponectin-mediated signaling pathway", "adiponectin-mediated signalling pathway"], "types": ["T043"], "canonical_name": "adiponectin-activated signaling pathway", "definition": "The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:20536390]"}
{"concept_id": "C2246620", "aliases": [], "types": ["T043"], "canonical_name": "iron assimilation"}
{"concept_id": "C2246621", "aliases": [], "types": ["T043"], "canonical_name": "iron assimilation by capture and transport"}
{"concept_id": "C2246622", "aliases": ["iron assimilation by chelation and transport"], "types": ["T043"], "canonical_name": "siderophore-dependent iron import into cell", "definition": "A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors. [GOC:mah, PMID:16963626]"}
{"concept_id": "C2246623", "aliases": ["iron assimilation by reduction and transport"], "types": ["T043"], "canonical_name": "reductive iron assimilation", "definition": "A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins. [GOC:cjm, GOC:mah, PMID:16963626]"}
{"concept_id": "C2246624", "aliases": ["ferric iron import", "ferric iron uptake"], "types": ["T043"], "canonical_name": "ferric ion import"}
{"concept_id": "C2246625", "aliases": ["regulation of transcription from RNA polymerase II promoter in response to iron deficiency"], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter in response to iron ion starvation", "definition": "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions. [GOC:mah]"}
{"concept_id": "C2246626", "aliases": [], "types": ["T044"], "canonical_name": "amide binding", "definition": "Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [GOC:mah]"}
{"concept_id": "C2246627", "aliases": [], "types": ["T044"], "canonical_name": "urea binding", "definition": "Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2246629", "aliases": ["urea-transporting ATPase activity", "carbamide-transporting ATPase activity", "ATP-dependent urea transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled urea transmembrane transporter activity", "definition": "Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in). [GOC:mlg]"}
{"concept_id": "C2246630", "aliases": [], "types": ["T044"], "canonical_name": "xylose binding", "definition": "Binding to the D- or L-enantiomer of xylose. [GOC:mah]"}
{"concept_id": "C2246631", "aliases": ["ciliatine transport", "2-phosphonoethylamine transport"], "types": ["T043"], "canonical_name": "2-aminoethylphosphonate transport", "definition": "The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mlg]"}
{"concept_id": "C2246633", "aliases": ["2-aminoethylphosphonate transporting ATPase activity", "2-aminoethylphosphonate-transporting ATPase activity", "ciliatine transportingATPase activity", "ATP-dependent 2-aminoethylphosphonate transporter activity", "2-phosphonoethylamine transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled 2-aminoethylphosphonate transporter activity", "definition": "Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in). [GOC:mlg]"}
{"concept_id": "C2246634", "aliases": ["2-phosphonoethylamine binding", "ciliatine binding"], "types": ["T044"], "canonical_name": "2-aminoethylphosphonate binding", "definition": "Binding to 2-aminoethylphosphonate. [GOC:mlg]"}
{"concept_id": "C2246635", "aliases": [], "types": ["T045"], "canonical_name": "dsRNA transport", "definition": "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2246636", "aliases": [], "types": ["T043"], "canonical_name": "cysteine export"}
{"concept_id": "C2246637", "aliases": [], "types": ["T044"], "canonical_name": "cysteine transmembrane transporter activity", "definition": "Enables the transfer of cysteine from one side of a membrane to the other. [GOC:mah, RHEA:32795]"}
{"concept_id": "C2246638", "aliases": ["ATPase-coupled cysteine transmembrane transporter activity", "ATPase-coupled cysteine transporter activity", "ATP-dependent cysteine transporter activity", "cysteine-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type cysteine transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out). [GOC:mlg, PMID:25837721, PMID:32144203]"}
{"concept_id": "C2246639", "aliases": [], "types": ["T043"], "canonical_name": "carbohydrate export", "definition": "The directed movement of carbohydrates out of a cell or organelle. [GOC:mlg]"}
{"concept_id": "C2246640", "aliases": ["ATP-dependent D-methionine transporter activity", "D-methionine-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled D-methionine transporter activity"}
{"concept_id": "C2246641", "aliases": ["regulation of sumoylation"], "types": ["T040"], "canonical_name": "regulation of protein sumoylation", "definition": "Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein. [GOC:mah]"}
{"concept_id": "C2246642", "aliases": ["negative regulation of sumoylation"], "types": ["T044"], "canonical_name": "negative regulation of protein sumoylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein. [GOC:mah]"}
{"concept_id": "C2246643", "aliases": ["positive regulation of sumoylation"], "types": ["T040"], "canonical_name": "positive regulation of protein sumoylation", "definition": "Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. [GOC:mah]"}
{"concept_id": "C2246644", "aliases": [], "types": ["T044"], "canonical_name": "11-beta-hydroxysteroid dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+. [PMID:15761036, RHEA:53116]"}
{"concept_id": "C2246645", "aliases": ["corticosteroid 11-beta-dehydrogenase activity"], "types": ["T044"], "canonical_name": "11-beta-hydroxysteroid dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+. [RHEA:11388]"}
{"concept_id": "C2246646", "aliases": ["beta-hydroxysteroid dehydrogenase"], "types": ["T044"], "canonical_name": "beta-hydroxysteroid dehydrogenase"}
{"concept_id": "C2246647", "aliases": ["regulation of amine metabolism"], "types": ["T040"], "canonical_name": "regulation of cellular amine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. [GOC:mah]"}
{"concept_id": "C2246648", "aliases": ["negative regulation of amine metabolism"], "types": ["T040"], "canonical_name": "negative regulation of cellular amine metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. [GOC:mah]"}
{"concept_id": "C2246649", "aliases": ["positive regulation of amine metabolism"], "types": ["T040"], "canonical_name": "positive regulation of cellular amine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. [GOC:mah]"}
{"concept_id": "C2246650", "aliases": ["regulation of amine breakdown", "regulation of amine degradation", "regulation of amine catabolism"], "types": ["T040"], "canonical_name": "regulation of cellular amine catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. [GOC:mah]"}
{"concept_id": "C2246651", "aliases": ["negative regulation of amine degradation", "negative regulation of amine catabolism", "negative regulation of amine breakdown"], "types": ["T040"], "canonical_name": "negative regulation of cellular amine catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. [GOC:mah]"}
{"concept_id": "C2246652", "aliases": ["positive regulation of amine degradation", "positive regulation of amine breakdown", "positive regulation of amine catabolism"], "types": ["T040"], "canonical_name": "positive regulation of cellular amine catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. [GOC:mah]"}
{"concept_id": "C2246653", "aliases": ["regulation of penicillin metabolism"], "types": ["T040"], "canonical_name": "regulation of penicillin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:mah]"}
{"concept_id": "C2246654", "aliases": ["negative regulation of penicillin metabolism"], "types": ["T040"], "canonical_name": "negative regulation of penicillin metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:mah]"}
{"concept_id": "C2246655", "aliases": ["positive regulation of penicillin metabolism"], "types": ["T040"], "canonical_name": "positive regulation of penicillin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:mah]"}
{"concept_id": "C2246656", "aliases": ["regulation of penicillin catabolism", "regulation of penicillin breakdown", "regulation of penicillin degradation"], "types": ["T040"], "canonical_name": "regulation of penicillin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:mah]"}
{"concept_id": "C2246657", "aliases": ["negative regulation of penicillin breakdown", "negative regulation of penicillin catabolism", "negative regulation of penicillin degradation"], "types": ["T040"], "canonical_name": "negative regulation of penicillin catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:mah]"}
{"concept_id": "C2246658", "aliases": ["positive regulation of penicillin degradation", "positive regulation of penicillin catabolism", "positive regulation of penicillin breakdown"], "types": ["T044"], "canonical_name": "positive regulation of penicillin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. [GOC:mah]"}
{"concept_id": "C2246659", "aliases": [], "types": ["T044"], "canonical_name": "penicillinase activity", "definition": "Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin. [GOC:mlg]"}
{"concept_id": "C2246660", "aliases": [], "types": ["T044"], "canonical_name": "cephalosporinase activity", "definition": "Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin. [GOC:mlg]"}
{"concept_id": "C2246661", "aliases": [], "types": ["T040"], "canonical_name": "regulation of beta-lactamase activity", "definition": "Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid. [GOC:mah]"}
{"concept_id": "C2246662", "aliases": [], "types": ["T040"], "canonical_name": "regulation of penicillinase activity", "definition": "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of a penicillin to yield a substituted beta-amino acid derivative. [GOC:mah]"}
{"concept_id": "C2246663", "aliases": ["VTC complex location", "VTC complex", "vacuolar transporter chaperone complex location"], "types": ["T026"], "canonical_name": "vacuolar transporter chaperone complex", "definition": "A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p. [PMID:11823419, PMID:17079729]"}
{"concept_id": "C2246664", "aliases": ["SAS-I complex", "SAS acetyltransferase complex location", "SAS-I complex location"], "types": ["T026"], "canonical_name": "SAS acetyltransferase complex", "definition": "A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p. [PMID:11731480, PMID:12626510, PMID:15788653]"}
{"concept_id": "C2246665", "aliases": ["I-kappaB/NF-kappaB complex location"], "types": ["T026"], "canonical_name": "I-kappaB/NF-kappaB complex", "definition": "A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. [GOC:bf, GOC:mah, PMID:9407099]"}
{"concept_id": "C2246666", "aliases": ["Bcl3/NF-kappaB2 complex location", "Bcl3-p52 complex location", "Bcl3-p52 complex"], "types": ["T026"], "canonical_name": "Bcl3/NF-kappaB2 complex", "definition": "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription. [GOC:mah, PMID:9407099]"}
{"concept_id": "C2246667", "aliases": ["Bcl3-NFKB2 complex location"], "types": ["T026"], "canonical_name": "Bcl3-NFKB2 complex"}
{"concept_id": "C2246668", "aliases": ["plastid DNA metabolism"], "types": ["T045"], "canonical_name": "plastid DNA metabolic process", "definition": "The chemical reactions and pathways involving plastid DNA. [GOC:mah]"}
{"concept_id": "C2246669", "aliases": ["replication of plastid DNA"], "types": ["T045"], "canonical_name": "plastid DNA replication", "definition": "The process in which new strands of DNA are synthesized in a plastid. [GOC:mah]"}
{"concept_id": "C2246670", "aliases": [], "types": ["T045"], "canonical_name": "plastid DNA synthesis"}
{"concept_id": "C2246671", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication during S phase"}
{"concept_id": "C2246673", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA replication during S phase"}
{"concept_id": "C2246674", "aliases": ["CORVET complex location"], "types": ["T026"], "canonical_name": "CORVET complex", "definition": "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p. [PMID:17488625]"}
{"concept_id": "C2246676", "aliases": [], "types": ["T044"], "canonical_name": "choline binding", "definition": "Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium. [GOC:mlg]"}
{"concept_id": "C2246677", "aliases": ["ATP-dependent choline transmembrane transporter activity", "choline-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled choline transmembrane transporter activity"}
{"concept_id": "C2246678", "aliases": ["internode"], "types": ["T026"], "canonical_name": "internode region of axon", "definition": "An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath. [GOC:mah, GOC:mh]"}
{"concept_id": "C2246679", "aliases": ["paranode"], "types": ["T026"], "canonical_name": "paranode region of axon", "definition": "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858]"}
{"concept_id": "C2246680", "aliases": [], "types": ["T043"], "canonical_name": "myo-inositol phosphate transport", "definition": "The directed movement of any phosphorylated myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2246681", "aliases": ["phytate transport"], "types": ["T043"], "canonical_name": "myo-inositol hexakisphosphate transport", "definition": "The directed movement of myo-inositol hexakisphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2246682", "aliases": [], "types": ["T043"], "canonical_name": "response to vitamin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. [GOC:sl]"}
{"concept_id": "C2246683", "aliases": ["response to riboflavin"], "types": ["T043"], "canonical_name": "response to vitamin B2", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus. [GOC:sl]"}
{"concept_id": "C2246684", "aliases": [], "types": ["T043"], "canonical_name": "actin-myosin filament sliding", "definition": "The sliding movement of actin thin filaments and myosin thick filaments past each other. [GOC:pf]"}
{"concept_id": "C2246685", "aliases": [], "types": ["T043"], "canonical_name": "actin filament sliding"}
{"concept_id": "C2246686", "aliases": ["transcription factor TFTC complex location"], "types": ["T026"], "canonical_name": "transcription factor TFTC complex", "definition": "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. [PMID:10373431, PMID:9603525]"}
{"concept_id": "C2246687", "aliases": [], "types": ["T043"], "canonical_name": "abortive mitotic cell cycle", "definition": "A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy. [GOC:mah, PMID:9573008]"}
{"concept_id": "C2246688", "aliases": [], "types": ["T043"], "canonical_name": "abortive mitosis"}
{"concept_id": "C2246689", "aliases": ["cell proliferation in mesencephalon"], "types": ["T043"], "canonical_name": "cell proliferation in midbrain", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. [GO_REF:0000021, GOC:dgf]"}
{"concept_id": "C2246690", "aliases": [], "types": ["T043"], "canonical_name": "mesencepahalic cell proliferation"}
{"concept_id": "C2246691", "aliases": ["response to calciferol"], "types": ["T043"], "canonical_name": "response to vitamin D", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. [GOC:sl]"}
{"concept_id": "C2246692", "aliases": [], "types": ["T043"], "canonical_name": "response to cholecalciferol"}
{"concept_id": "C2246693", "aliases": [], "types": ["T043"], "canonical_name": "response to ergocalciferol"}
{"concept_id": "C2246694", "aliases": ["TAT protein translocation system complex location"], "types": ["T026"], "canonical_name": "TAT protein translocation system complex"}
{"concept_id": "C2246695", "aliases": ["PCI-acrosin complex location", "plasma serine protease inhibitor-acrosin complex location", "SERPINA5-acrosin complex location", "PCI-ACR complex", "PCI-ACR complex location", "serpin A5-acrosin complex location", "SERPINA5-acrosin complex", "plasma serine protease inhibitor-acrosin complex", "protein C inhibitor-acrosin complex location", "serpin A5-acrosin complex", "PCI-acrosin complex"], "types": ["T026"], "canonical_name": "protein C inhibitor-acrosin complex", "definition": "A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin. [GOC:pr, PMID:11120760, PMID:7521127]"}
{"concept_id": "C2246696", "aliases": ["ATP-dependent organic acid transmembrane transporter activity", "organic acid-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled organic acid transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out). [GOC:mlg]"}
{"concept_id": "C2246697", "aliases": ["carboxylic acid-transporting ATPase activity", "ATP-dependent carboxylic acid transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled carboxylic acid transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out). [GOC:mlg]"}
{"concept_id": "C2246698", "aliases": ["monocarboxylic acid-transporting ATPase activity", "ATP-dependent monocarboxylic acid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled monocarboxylic acid transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out). [GOC:mlg]"}
{"concept_id": "C2246699", "aliases": ["ATP-dependent ectoine transmembrane transporter activity", "ectoine-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled ectoine transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out). [GOC:mlg, RHEA:32787]"}
{"concept_id": "C2246700", "aliases": [], "types": ["T044"], "canonical_name": "hydroxyectoine transmembrane transporter activity"}
{"concept_id": "C2246701", "aliases": ["ATP-dependent hydroxyectoine transmembrane transporter activity", "hydroxyectoine-transporting ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled hydroxyectoine transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out). [GOC:mlg]"}
{"concept_id": "C2246702", "aliases": [], "types": ["T026"], "canonical_name": "intraconoid microtubule", "definition": "A microtubule located such that it threads through the conoid and projects through the polar ring. [GOC:mah, PMID:11901169, PMID:16518471]"}
{"concept_id": "C2246703", "aliases": ["eukaryotic 48S pre-initiation complex", "eukaryotic 48S pre-initiation complex location", "eukaryotic 48S preinitiation complex location"], "types": ["T026"], "canonical_name": "eukaryotic 48S preinitiation complex", "definition": "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA. [GOC:hjd, PMID:15145049]"}
{"concept_id": "C2246704", "aliases": ["eukaryotic 48S initiation complex location"], "types": ["T026"], "canonical_name": "eukaryotic 48S initiation complex"}
{"concept_id": "C2246705", "aliases": ["eukaryotic 80S initiation complex location"], "types": ["T026"], "canonical_name": "eukaryotic 80S initiation complex", "definition": "A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region. [GOC:hjd, PMID:15145049]"}
{"concept_id": "C2246706", "aliases": ["transverse tubule organization", "T-tubule organization and biogenesis", "T-tubule organisation"], "types": ["T043"], "canonical_name": "T-tubule organization", "definition": "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C2246707", "aliases": [], "types": ["T044"], "canonical_name": "monocarboxylic acid binding", "definition": "Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). [GOC:mah]"}
{"concept_id": "C2246708", "aliases": [], "types": ["T044"], "canonical_name": "ectoine binding", "definition": "Binding to ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. [GOC:mah]"}
{"concept_id": "C2246709", "aliases": [], "types": ["T044"], "canonical_name": "hydroxyectoine binding", "definition": "Binding to hydroxyectoine. [GOC:mlg]"}
{"concept_id": "C2246710", "aliases": [], "types": ["T044"], "canonical_name": "rhamnose binding", "definition": "Binding to the D- or L-enantiomer of rhamnose. [GOC:mah]"}
{"concept_id": "C2246712", "aliases": ["contractile vacuole organization and biogenesis", "contractile vacuole organisation"], "types": ["T043"], "canonical_name": "contractile vacuole organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. [GOC:mah]"}
{"concept_id": "C2246713", "aliases": [], "types": ["T043"], "canonical_name": "secretion of lysosomal enzymes", "definition": "The controlled release of lysosomal enzymes by a cell. [GOC:mah]"}
{"concept_id": "C2246714", "aliases": ["dehydroascorbate transporter activity", "dehydroascorbic acid transporter activity"], "types": ["T044"], "canonical_name": "dehydroascorbic acid transmembrane transporter activity", "definition": "Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C2246715", "aliases": [], "types": ["T043"], "canonical_name": "cell cycle comprising mitosis without cytokinesis", "definition": "A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N). [GOC:expert_vm, GOC:mah]"}
{"concept_id": "C2246716", "aliases": ["quercetin O-glucoside metabolism"], "types": ["T044"], "canonical_name": "quercetin O-glucoside metabolic process", "definition": "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin. [GOC:mah, MetaCyc:PWY-5321]"}
{"concept_id": "C2246717", "aliases": ["quercetin O-glucoside biosynthesis", "quercetin O-glucoside anabolism", "quercetin O-glucoside formation", "quercetin O-glucoside synthesit"], "types": ["T044"], "canonical_name": "quercetin O-glucoside biosynthetic process", "definition": "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin. [GOC:mah, MetaCyc:PWY-5321]"}
{"concept_id": "C2246718", "aliases": ["chlorophyll a metabolism"], "types": ["T044"], "canonical_name": "chlorophyll a metabolic process", "definition": "The chemical reactions and pathways involving chlorophyll a. [GOC:mah]"}
{"concept_id": "C2246719", "aliases": ["chlorophyll a synthesis", "chlorophyll a formation", "chlorophyll a biosynthesis", "chlorophyll a anabolism"], "types": ["T044"], "canonical_name": "chlorophyll a biosynthetic process", "definition": "The chemical reactions and pathways leading to the formation of chlorophyll a. [GOC:mah]"}
{"concept_id": "C2246720", "aliases": ["phytol metabolism"], "types": ["T044"], "canonical_name": "phytol metabolic process", "definition": "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol. [GOC:mah]"}
{"concept_id": "C2246721", "aliases": ["phytol salvage pathway"], "types": ["T044"], "canonical_name": "phytol salvage", "definition": "A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis. [GOC:mah, MetaCyc:PWY-5107]"}
{"concept_id": "C2246722", "aliases": [], "types": ["T043"], "canonical_name": "hydroxyectoine transport", "definition": "The directed movement of hydroxyectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mlg]"}
{"concept_id": "C2246723", "aliases": ["SBF transcription complex location", "SBF complex location", "SBF complex"], "types": ["T026"], "canonical_name": "SBF transcription complex", "definition": "A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi4p and the activator Swi6p, and is associated with additional proteins known as Whi5p and Msa1p. [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:19150335, PMID:7917338]"}
{"concept_id": "C2246724", "aliases": ["chlorophyll a catabolism", "chlorophyll a breakdown", "chlorophyll a degradation"], "types": ["T044"], "canonical_name": "chlorophyll a catabolic process", "definition": "The chemical reactions and pathways leading to the breakdown of chlorophyll a. [GOC:mah]"}
{"concept_id": "C2246725", "aliases": ["chlorophyll a biosynthesis via phytyl diphosphate", "chlorophyll a formation via phytyl chlorophyll a formation via phytyl-PP", "chlorophyll a biosynthetic process via phytyl-PP", "chlorophyll a synthesis via phytyl diphosphate", "chlorophyll a anabolism via phytyl diphosphate"], "types": ["T044"], "canonical_name": "chlorophyll a biosynthetic process via phytyl diphosphate", "definition": "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate phytyl diphosphate. [GOC:mah, MetaCyc:PWY-5086]"}
{"concept_id": "C2246726", "aliases": ["chlorophyll a formation via geranylgeranyl-chlorophyll a", "chlorophyll a anabolism via geranylgeranyl-chlorophyll a", "chlorophyll a biosynthesis via geranylgeranyl-chlorophyll a", "chlorophyll a synthesis via geranylgeranyl-chlorophyll a"], "types": ["T044"], "canonical_name": "chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a", "definition": "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate geranylgeranyl-chlorophyll a. [GOC:mah, MetaCyc:PWY-5064]"}
{"concept_id": "C2246727", "aliases": ["signal transduction involved in meiotic cell cycle checkpoint", "meiotic cell cycle checkpoint"], "types": ["T043"], "canonical_name": "meiotic cell cycle checkpoint signaling", "definition": "A signaling process that contributes to a meiotic cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage. [GOC:mtg_cell_cycle]"}
{"concept_id": "C2246729", "aliases": ["signal transduction involved in meiotic DNA replication checkpoint", "meiotic cell cycle DNA replication checkpoint", "meiotic G2/MI DNA replication checkpoint"], "types": ["T045"], "canonical_name": "meiotic G2/MI DNA replication checkpoint signaling", "definition": "A signal transduction process that controls the G2/M1 transition of the meiotic cell cycle and prevents the initiation of nuclear division until DNA replication is complete. [GOC:mtg_cell_cycle]"}
{"concept_id": "C2246730", "aliases": ["meiotic spindle assembly checkpoint", "signal transduction involved in meiotic spindle assembly checkpoint"], "types": ["T043"], "canonical_name": "meiotic spindle assembly checkpoint signaling", "definition": "A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle. [GOC:mah]"}
{"concept_id": "C2246731", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate biosynthetic process from valine"}
{"concept_id": "C2246732", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate biosynthetic process from 2-dehydropantolactone"}
{"concept_id": "C2246733", "aliases": ["UDP-D-xylose metabolism"], "types": ["T044"], "canonical_name": "UDP-D-xylose metabolic process", "definition": "The chemical reactions and pathways involving UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate. [GOC:mah]"}
{"concept_id": "C2246734", "aliases": ["UDP-D-xylose anabolism", "UDP-D-xylose synthesis", "UDP-D-xylose formation", "UDP-D-xylose biosynthesis"], "types": ["T044"], "canonical_name": "UDP-D-xylose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate. [GOC:mah, MetaCyc:PWY-4821]"}
{"concept_id": "C2246735", "aliases": ["homomethionine metabolism"], "types": ["T044"], "canonical_name": "homomethionine metabolic process", "definition": "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation. [GOC:mah, MetaCyc:PWY-1186]"}
{"concept_id": "C2246736", "aliases": ["homomethionine anabolism", "homomethionine synthesis", "homomethionine biosynthesis", "homomethionine formation"], "types": ["T044"], "canonical_name": "homomethionine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation. [GOC:mah, MetaCyc:PWY-1186]"}
{"concept_id": "C2246737", "aliases": ["choline anabolism via CDP-choline", "choline biosynthesis via CDP-choline", "choline synthesis via CDP-choline", "choline formation via CDP-choline"], "types": ["T044"], "canonical_name": "choline biosynthetic process via CDP-choline", "definition": "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate CDP-choline. [GOC:mah, MetaCyc:PWY-3561]"}
{"concept_id": "C2246738", "aliases": ["choline synthesis via N-monomethylethanolamine", "choline anabolism via N-monomethylethanolamine", "choline formation via N-monomethylethanolamine", "choline biosynthesis via N-monomethylethanolamine"], "types": ["T044"], "canonical_name": "choline biosynthetic process via N-monomethylethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine. [GOC:mah, MetaCyc:PWY-3542]"}
{"concept_id": "C2246739", "aliases": ["choline anabolism via phosphoryl-ethanolamine", "choline synthesis via phosphoryl-ethanolamine", "choline formation via phosphoryl-ethanolamine", "choline biosynthesis via phosphoryl-ethanolamine"], "types": ["T044"], "canonical_name": "choline biosynthetic process via phosphoryl-ethanolamine", "definition": "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate phosphoryl-ethanolamine. [GOC:mah, MetaCyc:PWY-3385]"}
{"concept_id": "C2246740", "aliases": ["CSF secretion"], "types": ["T043"], "canonical_name": "cerebrospinal fluid secretion", "definition": "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces. [GOC:ln, http://users.ahsc.arizona.edu/davis/csf.htm, PMID:10716451]"}
{"concept_id": "C2246741", "aliases": [], "types": ["T043"], "canonical_name": "Leydig cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. [GOC:ln, PMID:12050120]"}
{"concept_id": "C2246742", "aliases": ["PMP targeting signal (mPTS) binding", "mPTS binding", "PMP targeting signal binding", "peroxisomal membrane protein (PMP) targeting signal (mPTS) binding"], "types": ["T044"], "canonical_name": "peroxisome membrane targeting sequence binding", "definition": "Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane. [GOC:rb, PMID:15133130, PMID:17020786]"}
{"concept_id": "C2246743", "aliases": ["kaempferol O-glucoside metabolism"], "types": ["T044"], "canonical_name": "kaempferol O-glucoside metabolic process", "definition": "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol. [GOC:mah, MetaCyc:PWY-5320]"}
{"concept_id": "C2246744", "aliases": ["kaempferol O-glucoside formation", "kaempferol O-glucoside synthesit", "kaempferol O-glucoside anabolism", "kaempferol O-glucoside biosynthesis"], "types": ["T044"], "canonical_name": "kaempferol O-glucoside biosynthetic process", "definition": "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol. [GOC:mah, MetaCyc:PWY-5320]"}
{"concept_id": "C2246745", "aliases": ["ent-kaurene metabolism"], "types": ["T044"], "canonical_name": "ent-kaurene metabolic process", "definition": "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins. [GOC:mah, MetaCyc:PWY-5032, PMID:17064690]"}
{"concept_id": "C2246746", "aliases": ["ent-kaurene biosynthesis", "ent-kaurene synthesis", "ent-kaurene anabolism", "ent-kaurene formation"], "types": ["T044"], "canonical_name": "ent-kaurene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ent-kaurene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins. [GOC:mah, MetaCyc:PWY-5032, PMID:17064690]"}
{"concept_id": "C2246747", "aliases": [], "types": ["T040"], "canonical_name": "fin development", "definition": "The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure. [GOC:dgh]"}
{"concept_id": "C2246748", "aliases": [], "types": ["T040"], "canonical_name": "fin morphogenesis", "definition": "The process in which the anatomical structures of a fin are generated and organized. [GOC:dgh]"}
{"concept_id": "C2246749", "aliases": [], "types": ["T040"], "canonical_name": "anal fin development", "definition": "The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure. [GOC:dgh]"}
{"concept_id": "C2246750", "aliases": [], "types": ["T040"], "canonical_name": "caudal fin development", "definition": "The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure. [GOC:dgh]"}
{"concept_id": "C2246751", "aliases": [], "types": ["T040"], "canonical_name": "dorsal fin development", "definition": "The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure. [GOC:dgh]"}
{"concept_id": "C2246752", "aliases": ["median fin development"], "types": ["T040"], "canonical_name": "medial fin development", "definition": "The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure. [GOC:dgh]"}
{"concept_id": "C2246753", "aliases": [], "types": ["T040"], "canonical_name": "pectoral fin development", "definition": "The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure. [GOC:dgh]"}
{"concept_id": "C2246754", "aliases": [], "types": ["T040"], "canonical_name": "pelvic fin development", "definition": "The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure. [GOC:dgh]"}
{"concept_id": "C2246755", "aliases": [], "types": ["T040"], "canonical_name": "regulation of collagen binding", "definition": "Any process that modulates the frequency, rate or extent of collagen binding. [GOC:mah]"}
{"concept_id": "C2246756", "aliases": ["down regulation of collagen binding", "down-regulation of collagen binding", "downregulation of collagen binding"], "types": ["T040"], "canonical_name": "negative regulation of collagen binding", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding. [GOC:mah]"}
{"concept_id": "C2246757", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of collagen binding"}
{"concept_id": "C2246758", "aliases": ["upregulation of collagen binding", "up regulation of collagen binding", "up-regulation of collagen binding"], "types": ["T040"], "canonical_name": "positive regulation of collagen binding", "definition": "Any process that activates or increases the frequency, rate or extent of collagen binding. [GOC:mah]"}
{"concept_id": "C2246759", "aliases": [], "types": ["T040"], "canonical_name": "activation of collagen binding"}
{"concept_id": "C2246760", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of collagen binding"}
{"concept_id": "C2246761", "aliases": ["cholesterol export"], "types": ["T043"], "canonical_name": "cholesterol efflux", "definition": "The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:sart]"}
{"concept_id": "C2246762", "aliases": [], "types": ["T044"], "canonical_name": "asparagine catabolic process via L-aspartate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate. [GOC:mah]"}
{"concept_id": "C2246763", "aliases": [], "types": ["T044"], "canonical_name": "asparagine catabolic process via 2-oxosuccinamate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate. [GOC:mah, MetaCyc:PWY-4002]"}
{"concept_id": "C2246764", "aliases": ["tetrose metabolism"], "types": ["T044"], "canonical_name": "tetrose metabolic process", "definition": "The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule. [GOC:mah]"}
{"concept_id": "C2246765", "aliases": ["tetrose formation", "tetrose synthesis", "tetrose biosynthesis", "tetrose anabolism"], "types": ["T044"], "canonical_name": "tetrose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule. [GOC:mah]"}
{"concept_id": "C2246766", "aliases": ["apiose metabolism"], "types": ["T044"], "canonical_name": "apiose metabolic process", "definition": "The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose. [GOC:mah]"}
{"concept_id": "C2246767", "aliases": ["apiose anabolism", "apiose biosynthesis", "apiose formation", "apiose synthesis"], "types": ["T044"], "canonical_name": "apiose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose. [GOC:mah]"}
{"concept_id": "C2246768", "aliases": ["UDP-D-apiose metabolism"], "types": ["T044"], "canonical_name": "UDP-D-apiose metabolic process", "definition": "The chemical reactions and pathways involving UDP-D-apiose, uridinediphosphoapiose, a substance composed of apiose in glycosidic linkage with uridine diphosphate. [GOC:mah]"}
{"concept_id": "C2246769", "aliases": ["UDP-D-apiose biosynthesis", "UDP-D-apiose anabolism", "UDP-D-apiose formation", "UDP-D-apiose synthesis"], "types": ["T044"], "canonical_name": "UDP-D-apiose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate. [GOC:mah, MetaCyc:PWY-5113]"}
{"concept_id": "C2246770", "aliases": ["activated methyl cycle", "SAM cycle"], "types": ["T044"], "canonical_name": "S-adenosylmethionine cycle", "definition": "A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine. [GOC:mah, MetaCyc:PWY-5041]"}
{"concept_id": "C2246771", "aliases": [], "types": ["T044"], "canonical_name": "chlorophyll cycle", "definition": "A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates. [GOC:mah, MetaCyc:PWY-5068]"}
{"concept_id": "C2246772", "aliases": [], "types": ["T044"], "canonical_name": "ascorbate glutathione cycle", "definition": "A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH. [GOC:mah, MetaCyc:PWY-2261]"}
{"concept_id": "C2246773", "aliases": ["detoxification of hydrogen peroxide", "hydrogen peroxide detoxification", "detoxification of H2O2"], "types": ["T044"], "canonical_name": "detoxification of hydrogen peroxide", "definition": "Any process that reduces or removes the toxicity of hydrogen peroxide. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration. [GOC:dph]"}
{"concept_id": "C2246774", "aliases": ["UDP-L-arabinose metabolism"], "types": ["T044"], "canonical_name": "UDP-L-arabinose metabolic process", "definition": "The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate. [GOC:mah]"}
{"concept_id": "C2246775", "aliases": ["L-arabinose synthesis", "L-arabinose anabolism", "L-arabinose formation", "L-arabinose biosynthesis"], "types": ["T044"], "canonical_name": "L-arabinose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose. [GOC:mah]"}
{"concept_id": "C2246776", "aliases": ["UDP-L-arabinose anabolism", "UDP-L-arabinose formation", "UDP-L-arabinose synthesis", "UDP-L-arabinose biosynthesis"], "types": ["T044"], "canonical_name": "UDP-L-arabinose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate. [GOC:mah, MetaCyc:PWY-82]"}
{"concept_id": "C2246777", "aliases": ["lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate", "lysine biosynthesis via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate", "lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate", "lysine anabolism via diaminopimelate and N-succinyl-2-amino-6-ketopimelate", "lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate"], "types": ["T044"], "canonical_name": "lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate", "definition": "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps. [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-]"}
{"concept_id": "C2246778", "aliases": ["lysine formation via diaminopimelate and L-2-acetamido-6-oxoheptanedioate", "lysine anabolism via diaminopimelate and L-2-acetamido-6-oxoheptanedioate", "lysine biosynthesis via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate", "lysine biosynthetic process via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate", "lysine synthesis via diaminopimelate and L-2-acetamido-6-oxoheptanedioate"], "types": ["T044"], "canonical_name": "lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate", "definition": "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps. [GOC:mah, MetaCyc:PWY-2941]"}
{"concept_id": "C2246779", "aliases": ["lysine synthesis via diaminopimelate, dehydrogenase pathway", "lysine anabolism via diaminopimelate, dehydrogenase pathway", "lysine formation via diaminopimelate, dehydrogenase pathway", "lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway"], "types": ["T044"], "canonical_name": "lysine biosynthetic process via diaminopimelate, dehydrogenase pathway", "definition": "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step. [GOC:mah, GOC:pr, MetaCyc:PWY-2942]"}
{"concept_id": "C2246780", "aliases": ["lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway", "lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway", "lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway", "lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway"], "types": ["T044"], "canonical_name": "lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway", "definition": "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps. [GOC:mah, GOC:pr, MetaCyc:PWY-5097]"}
{"concept_id": "C2246781", "aliases": ["secretory granule organisation", "secretory granule organization and biogenesis"], "types": ["T043"], "canonical_name": "secretory granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. [GOC:mah]"}
{"concept_id": "C2246782", "aliases": ["mast cell secretory granule organization and biogenesis", "mast cell secretory granule organisation"], "types": ["T043"], "canonical_name": "mast cell secretory granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. [GOC:mah]"}
{"concept_id": "C2246783", "aliases": [], "types": ["T043"], "canonical_name": "mast cell secretory granule maturation"}
{"concept_id": "C2246784", "aliases": ["protein localization in organelle", "protein localisation to organelle"], "types": ["T043"], "canonical_name": "protein localization to organelle", "definition": "A process in which a protein is transported to, or maintained in, a location within an organelle. [GOC:mah]"}
{"concept_id": "C2246785", "aliases": ["protein localization in secretory granule", "protein localisation in secretory granule"], "types": ["T043"], "canonical_name": "protein localization to secretory granule", "definition": "A process in which a protein is transported to, or maintained in, a location within a secretory granule. [GOC:mah]"}
{"concept_id": "C2246786", "aliases": ["protein localisation in mast cell secretory granule", "protein localization in mast cell secretory granule"], "types": ["T043"], "canonical_name": "protein localization to mast cell secretory granule", "definition": "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell. [GOC:mah]"}
{"concept_id": "C2246787", "aliases": ["protease localization in mast cell secretory granule", "protease localisation in mast cell secretory granule"], "types": ["T043"], "canonical_name": "protease localization to mast cell secretory granule", "definition": "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell. [GOC:mah]"}
{"concept_id": "C2246788", "aliases": ["establishment of protein localization in mast cell secretory granule", "establishment of protein localisation in mast cell secretory granule"], "types": ["T043"], "canonical_name": "establishment of protein localization to mast cell secretory granule", "definition": "The directed movement of a protein to a location within a secretory granule in a mast cell. [GOC:mah]"}
{"concept_id": "C2246789", "aliases": ["mast cell protein retention", "maintenance of protein localization in mast cell secretory granule"], "types": ["T043"], "canonical_name": "maintenance of protein location in mast cell secretory granule", "definition": "A process in which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2246790", "aliases": ["T cell secretory granule organization and biogenesis", "T-cell secretory granule organization", "T-lymphocyte secretory granule organization", "T lymphocyte secretory granule organization", "T cell secretory granule organisation"], "types": ["T043"], "canonical_name": "T cell secretory granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. [GOC:mah]"}
{"concept_id": "C2246791", "aliases": [], "types": ["T043"], "canonical_name": "T-lymphocyte secretory granule maturation"}
{"concept_id": "C2246792", "aliases": ["establishment of protease localisation in mast cell secretory granule", "establishment of protease localization in mast cell secretory granule"], "types": ["T043"], "canonical_name": "establishment of protease localization to mast cell secretory granule", "definition": "The directed movement of a protease to a location within a secretory granule in a mast cell. [GOC:mah]"}
{"concept_id": "C2246793", "aliases": ["mast cell protease retention", "maintenance of protease localization in mast cell secretory granule"], "types": ["T043"], "canonical_name": "maintenance of protease location in mast cell secretory granule", "definition": "A process in which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2246794", "aliases": ["protein localisation in T cell secretory granule", "protein localization in T cell secretory granule", "protein localization in T lymphocyte secretory granule", "protein localization in T-lymphocyte secretory granule", "protein localization in T-cell secretory granule"], "types": ["T043"], "canonical_name": "protein localization to T cell secretory granule", "definition": "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell. [GOC:mah]"}
{"concept_id": "C2246795", "aliases": ["protease localization in T lymphocyte secretory granule", "protease localisation in T cell secretory granule", "protease localization in T-cell secretory granule", "protease localization in T-lymphocyte secretory granule", "protease localization in T cell secretory granule"], "types": ["T043"], "canonical_name": "protease localization to T cell secretory granule", "definition": "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell. [GOC:mah]"}
{"concept_id": "C2246796", "aliases": ["establishment of protein localization in T-lymphocyte secretory granule", "establishment of protein localization in T lymphocyte secretory granule", "establishment of protein localisation in T cell secretory granule", "establishment of protein localization in T-cell secretory granule", "establishment of protein localization in T cell secretory granule"], "types": ["T043"], "canonical_name": "establishment of protein localization to T cell secretory granule", "definition": "The directed movement of a protein to a location within a secretory granule in a T cell. [GOC:mah]"}
{"concept_id": "C2246797", "aliases": ["maintenance of protein localization in T-lymphocyte secretory granule", "maintenance of protein localization in T lymphocyte secretory granule", "maintenance of protein localization in T-cell secretory granule", "maintenance of protein localization in T cell secretory granule"], "types": ["T043"], "canonical_name": "maintenance of protein location in T cell secretory granule", "definition": "A process in which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2246798", "aliases": ["establishment of protease localization in T-lymphocyte secretory granule", "establishment of protease localisation in T cell secretory granule", "establishment of protease localization in T lymphocyte secretory granule", "establishment of protease localization in T-cell secretory granule", "establishment of protease localization in T cell secretory granule"], "types": ["T043"], "canonical_name": "establishment of protease localization to T cell secretory granule", "definition": "The directed movement of a protease to a location within a secretory granule in a T cell. [GOC:mah]"}
{"concept_id": "C2246799", "aliases": ["maintenance of protease localization in T-lymphocyte secretory granule", "maintenance of protease localization in T-cell secretory granule", "maintenance of protease localization in T cell secretory granule", "maintenance of protease localization in T lymphocyte secretory granule"], "types": ["T043"], "canonical_name": "maintenance of protease location in T cell secretory granule", "definition": "A process in which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2246800", "aliases": ["granzyme B localization in T lymphocyte secretory granule", "granzyme B localization in T-lymphocyte secretory granule", "granzyme B localization in T cell secretory granule", "granzyme B localization in T-cell secretory granule", "granzyme B localisation in T cell secretory granule"], "types": ["T043"], "canonical_name": "granzyme B localization to T cell secretory granule", "definition": "Any process in which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell. [GOC:mah]"}
{"concept_id": "C2246801", "aliases": ["establishment of granzyme B localization in T-cell secretory granule", "establishment of granzyme B localisation in T cell secretory granule", "establishment of granzyme B localization in T-lymphocyte secretory granule", "establishment of granzyme B localization in T lymphocyte secretory granule", "establishment of granzyme B localization in T cell secretory granule"], "types": ["T043"], "canonical_name": "establishment of granzyme B localization to T cell secretory granule", "definition": "The directed movement of the protease granzyme B to a location within a secretory granule in a T cell. [GOC:mah]"}
{"concept_id": "C2246802", "aliases": [], "types": ["T043"], "canonical_name": "T-lymphocyte secretory granule storage of granzyme B"}
{"concept_id": "C2246803", "aliases": ["maintenance of granzyme B localization in T-cell secretory granule", "maintenance of granzyme B localization in T cell secretory granule", "maintenance of granzyme B localization in T-lymphocyte secretory granule", "maintenance of granzyme B localization in T lymphocyte secretory granule"], "types": ["T043"], "canonical_name": "maintenance of granzyme B location in T cell secretory granule", "definition": "A process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere. [GOC:mah]"}
{"concept_id": "C2246804", "aliases": ["geranyl diphosphate metabolism", "geranyldiphosphate metabolic process"], "types": ["T044"], "canonical_name": "geranyl diphosphate metabolic process", "definition": "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes. [GOC:mah, MetaCyc:PWY-5122]"}
{"concept_id": "C2246805", "aliases": ["geranyl diphosphate formation", "geranyl diphosphate synthesis", "geranyl diphosphate biosynthesis", "geranyldiphosphate biosynthetic process", "geranyl diphosphate anabolism"], "types": ["T044"], "canonical_name": "geranyl diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of geranyl diphosphate. [GOC:mah, MetaCyc:PWY-5122]"}
{"concept_id": "C2246806", "aliases": ["geranylgeranyldiphosphate metabolic process", "geranylgeranyl diphosphate metabolism"], "types": ["T044"], "canonical_name": "geranylgeranyl diphosphate metabolic process", "definition": "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins. [GOC:mah, MetaCyc:PWY-5120]"}
{"concept_id": "C2246807", "aliases": ["geranylgeranyl diphosphate biosynthesis", "geranylgeranyl diphosphate formation", "geranylgeranyl diphosphate synthesis", "geranylgeranyl diphosphate anabolism"], "types": ["T044"], "canonical_name": "geranylgeranyl diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate. [GOC:mah, MetaCyc:PWY-5120]"}
{"concept_id": "C2246808", "aliases": ["putrescine anabolism from ornithine", "putrescine formation from ornithine", "putrescine biosynthesis from ornithine", "putrescine synthesis from ornithine"], "types": ["T044"], "canonical_name": "putrescine biosynthetic process from ornithine", "definition": "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine. [GOC:mah, MetaCyc:PWY-46]"}
{"concept_id": "C2246809", "aliases": ["putrescine anabolism from arginine", "putrescine synthesis from arginine", "putrescine formation from arginine", "putrescine biosynthesis from arginine"], "types": ["T044"], "canonical_name": "putrescine biosynthetic process from arginine", "definition": "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine. [GOC:mah, MetaCyc:PWY-46]"}
{"concept_id": "C2246810", "aliases": ["putrescine biosynthesis from arginine, using agmatinase", "putrescine formation from arginine, using agmatinase", "putrescine anabolism from arginine, using agmatinase", "putrescine synthesis from arginine, using agmatinase"], "types": ["T044"], "canonical_name": "putrescine biosynthetic process from arginine, using agmatinase", "definition": "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step. [GOC:mah, MetaCyc:PWY-40]"}
{"concept_id": "C2246811", "aliases": ["putrescine anabolism from arginine via N-carbamoylputrescine", "putrescine biosynthesis from arginine via N-carbamoylputrescine", "putrescine formation from arginine via N-carbamoylputrescine", "putrescine synthesis from arginine via N-carbamoylputrescine"], "types": ["T044"], "canonical_name": "putrescine biosynthetic process from arginine via N-carbamoylputrescine", "definition": "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps. [GOC:mah, MetaCyc:PWY-43]"}
{"concept_id": "C2246812", "aliases": [], "types": ["T026"], "definition": "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). [PMID:17183363]", "canonical_name": "chromatoid body"}
{"concept_id": "C2246815", "aliases": ["homogalacturonan catabolism", "homogalacturonan breakdown", "homogalacturonan degradation"], "types": ["T044"], "canonical_name": "homogalacturonan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of homogalacturonan, a pectidic polymer, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. [GOC:mah]"}
{"concept_id": "C2246816", "aliases": ["beta-alanine synthesis via 1,3 diaminopropane", "beta-alanine biosynthesis via 1,3 diaminopropane", "beta-alanine anabolism via 1,3 diaminopropane", "beta-alanine formation via 1,3 diaminopropane"], "types": ["T044"], "canonical_name": "beta-alanine biosynthetic process via 1,3 diaminopropane", "definition": "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane. [GOC:mah, MetaCyc:PWY-3981]"}
{"concept_id": "C2246817", "aliases": ["beta-alanine synthesis via 3-hydroxypropionate", "beta-alanine biosynthesis via 3-hydroxypropionate", "beta-alanine formation via 3-hydroxypropionate", "beta-alanine anabolism via 3-hydroxypropionate"], "types": ["T044"], "canonical_name": "beta-alanine biosynthetic process via 3-hydroxypropionate", "definition": "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate. [GOC:mah, MetaCyc:PWY-3941]"}
{"concept_id": "C2246818", "aliases": ["beta-alanine anabolism via 3-ureidopropionate", "beta-alanine synthesis via 3-ureidopropionate", "beta-alanine formation via 3-ureidopropionate"], "types": ["T044"], "canonical_name": "beta-alanine biosynthetic process via 3-ureidopropionate", "definition": "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate. [GOC:mah, MetaCyc:PWY-3982]"}
{"concept_id": "C2246819", "aliases": ["zeatin metabolism"], "types": ["T044"], "canonical_name": "zeatin metabolic process", "definition": "The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. [GOC:mah]"}
{"concept_id": "C2246820", "aliases": ["zeatin anabolism", "zeatin synthesis", "zeatin formation", "zeatin biosynthesis"], "types": ["T044"], "canonical_name": "zeatin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. [GOC:mah]"}
{"concept_id": "C2246821", "aliases": ["cis-zeatin metabolism"], "types": ["T044"], "canonical_name": "cis-zeatin metabolic process", "definition": "The chemical reactions and pathways involving cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. [GOC:mah]"}
{"concept_id": "C2246822", "aliases": ["trans-zeatin metabolism"], "types": ["T044"], "canonical_name": "trans-zeatin metabolic process", "definition": "The chemical reactions and pathways involving trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. [GOC:mah]"}
{"concept_id": "C2246823", "aliases": ["TTT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UUU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UUU codon. [GOC:mah]"}
{"concept_id": "C2246824", "aliases": ["TTC codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UUC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UUC codon. [GOC:mah]"}
{"concept_id": "C2246825", "aliases": ["TTA codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UUA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UUA codon. [GOC:mah]"}
{"concept_id": "C2246826", "aliases": ["TTG codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UUG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UUG codon. [GOC:mah]"}
{"concept_id": "C2246827", "aliases": ["TCT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UCU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UCU codon. [GOC:mah]"}
{"concept_id": "C2246828", "aliases": ["TCC codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UCC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UCC codon. [GOC:mah]"}
{"concept_id": "C2246829", "aliases": ["TCA codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UCA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UCA codon. [GOC:mah]"}
{"concept_id": "C2246830", "aliases": ["TCG codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UCG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UCG codon. [GOC:mah]"}
{"concept_id": "C2246831", "aliases": ["TAT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UAU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UAU codon. [GOC:mah]"}
{"concept_id": "C2246832", "aliases": ["TAC codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UAC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UAC codon. [GOC:mah]"}
{"concept_id": "C2246833", "aliases": ["TAA codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UAA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UAA codon. [GOC:mah]"}
{"concept_id": "C2246834", "aliases": ["TAG codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UAG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UAG codon. [GOC:mah]"}
{"concept_id": "C2246835", "aliases": ["TGT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UGU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UGU codon. [GOC:mah]"}
{"concept_id": "C2246836", "aliases": ["TGC codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UGC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UGC codon. [GOC:mah]"}
{"concept_id": "C2246837", "aliases": ["TGA codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UGA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UGA codon. [GOC:mah]"}
{"concept_id": "C2246838", "aliases": ["TGG codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "UGG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a UGG codon. [GOC:mah]"}
{"concept_id": "C2246839", "aliases": ["CTT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "CUU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CUU codon. [GOC:mah]"}
{"concept_id": "C2246840", "aliases": ["CTC codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "CUC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CUC codon. [GOC:mah]"}
{"concept_id": "C2246841", "aliases": ["CTA codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "CUA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CUA codon. [GOC:mah]"}
{"concept_id": "C2246842", "aliases": ["CTG codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "CUG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CUG codon. [GOC:mah]"}
{"concept_id": "C2246843", "aliases": ["CCT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "CCU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CCU codon. [GOC:mah]"}
{"concept_id": "C2246844", "aliases": [], "types": ["T045"], "canonical_name": "CCC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CCC codon. [GOC:mah]"}
{"concept_id": "C2246845", "aliases": [], "types": ["T045"], "canonical_name": "CCA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CCA codon. [GOC:mah]"}
{"concept_id": "C2246846", "aliases": [], "types": ["T045"], "canonical_name": "CCG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CCG codon. [GOC:mah]"}
{"concept_id": "C2246847", "aliases": ["CAT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "CAU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CAU codon. [GOC:mah]"}
{"concept_id": "C2246848", "aliases": [], "types": ["T045"], "canonical_name": "CAC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CAC codon. [GOC:mah]"}
{"concept_id": "C2246849", "aliases": [], "types": ["T045"], "canonical_name": "CAA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CAA codon. [GOC:mah]"}
{"concept_id": "C2246850", "aliases": [], "types": ["T045"], "canonical_name": "CAG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CAG codon. [GOC:mah]"}
{"concept_id": "C2246851", "aliases": ["CGT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "CGU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CGU codon. [GOC:mah]"}
{"concept_id": "C2246852", "aliases": [], "types": ["T045"], "canonical_name": "CGC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CGC codon. [GOC:mah]"}
{"concept_id": "C2246853", "aliases": [], "types": ["T045"], "canonical_name": "CGA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CGA codon. [GOC:mah]"}
{"concept_id": "C2246854", "aliases": [], "types": ["T045"], "canonical_name": "CGG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a CGG codon. [GOC:mah]"}
{"concept_id": "C2246855", "aliases": ["ATT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "AUU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AUU codon. [GOC:mah]"}
{"concept_id": "C2246856", "aliases": ["ATC codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "AUC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AUC codon. [GOC:mah]"}
{"concept_id": "C2246857", "aliases": ["ATA codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "AUA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AUA codon. [GOC:mah]"}
{"concept_id": "C2246858", "aliases": ["ATG codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "AUG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AUG codon. [GOC:mah]"}
{"concept_id": "C2246859", "aliases": ["ACT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "ACU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an ACU codon. [GOC:mah]"}
{"concept_id": "C2246860", "aliases": [], "types": ["T045"], "canonical_name": "ACC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an ACC codon. [GOC:mah]"}
{"concept_id": "C2246861", "aliases": [], "types": ["T045"], "canonical_name": "ACA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an ACA codon. [GOC:mah]"}
{"concept_id": "C2246862", "aliases": [], "types": ["T045"], "canonical_name": "ACG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an ACG codon. [GOC:mah]"}
{"concept_id": "C2246863", "aliases": ["AAT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "AAU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AAU codon. [GOC:mah]"}
{"concept_id": "C2246864", "aliases": [], "types": ["T045"], "canonical_name": "AAC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AAC codon. [GOC:mah]"}
{"concept_id": "C2246865", "aliases": [], "types": ["T045"], "canonical_name": "AAA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AAA codon. [GOC:mah]"}
{"concept_id": "C2246866", "aliases": [], "types": ["T045"], "canonical_name": "AAG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AAG codon. [GOC:mah]"}
{"concept_id": "C2246867", "aliases": ["AGT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "AGU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AGU codon. [GOC:mah]"}
{"concept_id": "C2246868", "aliases": [], "types": ["T045"], "canonical_name": "AGC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AGC codon. [GOC:mah]"}
{"concept_id": "C2246869", "aliases": [], "types": ["T045"], "canonical_name": "AGA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AGA codon. [GOC:mah]"}
{"concept_id": "C2246870", "aliases": [], "types": ["T045"], "canonical_name": "AGG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes an AGG codon. [GOC:mah]"}
{"concept_id": "C2246871", "aliases": ["GTT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "GUU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GUU codon. [GOC:mah]"}
{"concept_id": "C2246872", "aliases": ["GTC codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "GUC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GUC codon. [GOC:mah]"}
{"concept_id": "C2246873", "aliases": ["GTA codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "GUA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GUA codon. [GOC:mah]"}
{"concept_id": "C2246874", "aliases": ["GTG codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "GUG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GUG codon. [GOC:mah]"}
{"concept_id": "C2246875", "aliases": ["GCT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "GCU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GCU codon. [GOC:mah]"}
{"concept_id": "C2246876", "aliases": [], "types": ["T045"], "canonical_name": "GCC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GCC codon. [GOC:mah]"}
{"concept_id": "C2246877", "aliases": [], "types": ["T045"], "canonical_name": "GCA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GCA codon. [GOC:mah]"}
{"concept_id": "C2246878", "aliases": [], "types": ["T045"], "canonical_name": "GCG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GCG codon. [GOC:mah]"}
{"concept_id": "C2246879", "aliases": ["GAT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "GAU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GAU codon. [GOC:mah]"}
{"concept_id": "C2246880", "aliases": [], "types": ["T045"], "canonical_name": "GAC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GAC codon. [GOC:mah]"}
{"concept_id": "C2246881", "aliases": [], "types": ["T045"], "canonical_name": "GAA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GAA codon. [GOC:mah]"}
{"concept_id": "C2246882", "aliases": [], "types": ["T045"], "canonical_name": "GAG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GAG codon. [GOC:mah]"}
{"concept_id": "C2246883", "aliases": ["GGT codon-amino acid adaptor activity"], "types": ["T045"], "canonical_name": "GGU codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GGU codon. [GOC:mah]"}
{"concept_id": "C2246884", "aliases": [], "types": ["T045"], "canonical_name": "GGC codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GGC codon. [GOC:mah]"}
{"concept_id": "C2246885", "aliases": [], "types": ["T045"], "canonical_name": "GGA codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GGA codon. [GOC:mah]"}
{"concept_id": "C2246886", "aliases": [], "types": ["T045"], "canonical_name": "GGG codon-amino acid adaptor activity", "definition": "A triplet codon-amino acid adaptor activity that recognizes a GGG codon. [GOC:mah]"}
{"concept_id": "C2246887", "aliases": ["cis-zeatin biosynthesis", "cis-zeatin formation", "cis-zeatin anabolism", "cis-zeatin synthesis"], "types": ["T044"], "canonical_name": "cis-zeatin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. [GOC:mah]"}
{"concept_id": "C2246888", "aliases": ["trans-zeatin synthesis", "trans-zeatin biosynthesis", "trans-zeatin formation", "trans-zeatin anabolism"], "types": ["T044"], "canonical_name": "trans-zeatin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. [GOC:mah]"}
{"concept_id": "C2246889", "aliases": ["CMP-ketodeoxyoctanoate metabolic process", "CMP-KDO metabolic process", "CMP-keto-3-deoxy-D-manno-octulosonic acid metabolism"], "types": ["T044"], "canonical_name": "CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process", "definition": "The chemical reactions and pathways involving CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate. [GOC:mah, MetaCyc:PWY-5111]"}
{"concept_id": "C2246890", "aliases": ["CMP-keto-3-deoxy-D-manno-octulosonic acid anabolism", "CMP-keto-3-deoxy-D-manno-octulosonic acid synthesis", "CMP-keto-3-deoxy-D-manno-octulosonic acid formation", "CMP-ketodeoxyoctanoate biosynthetic process", "CMP-KDO biosynthetic process", "CMP-KDO biosynthesis", "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthesis"], "types": ["T044"], "canonical_name": "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate. [GOC:mah, MetaCyc:PWY-5111]"}
{"concept_id": "C2246891", "aliases": ["GA12 metabolic process", "gibberellin 12 metabolism", "gibberellin A12 metabolic process"], "types": ["T044"], "canonical_name": "gibberellin 12 metabolic process", "definition": "The chemical reactions and pathways involving gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid. [GOC:mah]"}
{"concept_id": "C2246892", "aliases": ["gibberellin 12 formation", "gibberellin 12 anabolism", "gibberellin 12 biosynthesis", "gibberellin 12 synthesis", "gibberellin A12 biosynthetic process", "GA12 biosynthetic process"], "types": ["T044"], "canonical_name": "gibberellin 12 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid. [GOC:mah]"}
{"concept_id": "C2246893", "aliases": ["GDP-L-galactose metabolism"], "types": ["T044"], "canonical_name": "GDP-L-galactose metabolic process", "definition": "The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate. [GOC:mah]"}
{"concept_id": "C2246894", "aliases": ["GDP-L-galactose formation", "GDP-L-galactose anabolism", "GDP-L-galactose biosynthesis", "GDP-L-galactose synthesis"], "types": ["T044"], "canonical_name": "GDP-L-galactose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate. [GOC:mah]"}
{"concept_id": "C2246895", "aliases": ["indoleacetic acid conjugate metabolism", "IAA conjugate metabolic process", "indole acetic acid conjugate metabolism", "indole acetic acid conjugate metabolic process"], "types": ["T044"], "canonical_name": "indoleacetic acid conjugate metabolic process", "definition": "The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule. [GOC:mah]"}
{"concept_id": "C2246896", "aliases": ["indoleacetic acid conjugate anabolism", "indoleacetic acid conjugate synthesis", "IAA conjugate biosynthetic process", "indole acetic acid conjugate biosynthesis", "indoleacetic acid conjugate formation", "indoleacetic acid conjugate biosynthesis", "indole acetic acid conjugate biosynthetic process"], "types": ["T044"], "canonical_name": "indoleacetic acid conjugate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule. [GOC:mah]"}
{"concept_id": "C2246897", "aliases": ["indoleacetic acid amide conjugate biosynthesis", "indole acetic acid amide conjugate biosynthetic process", "indole acetic acid amide conjugate biosynthesis", "indoleacetic acid amide conjugate synthesis", "indoleacetic acid amide conjugate anabolism", "IAA amide conjugate biosynthetic process", "indoleacetic acid amide conjugate formation"], "types": ["T044"], "canonical_name": "indoleacetic acid amide conjugate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond. [GOC:mah, MetaCyc:PWY-1782]"}
{"concept_id": "C2246898", "aliases": ["indoleacetic acid ester conjugate synthesis", "indoleacetic acid ester conjugate formation", "indole acetic acid ester conjugate biosynthetic process", "indoleacetic acid ester conjugate biosynthesis", "indole acetic acid ester conjugate biosynthesis", "IAA ester conjugate biosynthetic process", "indoleacetic acid ester conjugate anabolism"], "types": ["T044"], "canonical_name": "indoleacetic acid ester conjugate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond. [GOC:mah, MetaCyc:PWY-1741]"}
{"concept_id": "C2246899", "aliases": ["S-methylmethionine metabolism"], "types": ["T044"], "canonical_name": "S-methylmethionine metabolic process", "definition": "The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle. [GOC:mah, PMID:12692340]"}
{"concept_id": "C2246900", "aliases": ["UDP-rhamnose metabolism"], "types": ["T044"], "canonical_name": "UDP-rhamnose metabolic process", "definition": "The chemical reactions and pathways involving UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate. [GOC:mah, PMID:15134748]"}
{"concept_id": "C2246901", "aliases": ["UDP-D-galacturonate metabolism"], "types": ["T044"], "canonical_name": "UDP-D-galacturonate metabolic process", "definition": "The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate. [GOC:mah]"}
{"concept_id": "C2246902", "aliases": ["UDP-D-galacturonate biosynthesis", "UDP-D-galacturonate synthesis", "UDP-D-galacturonate anabolism", "UDP-D-galacturonate formation"], "types": ["T044"], "canonical_name": "UDP-D-galacturonate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate. [GOC:mah]"}
{"concept_id": "C2246903", "aliases": ["galacturonate anabolism", "galacturonate synthesis", "galacturonate formation", "galacturonate biosynthesis"], "types": ["T044"], "canonical_name": "galacturonate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid. [GOC:mah]"}
{"concept_id": "C2246904", "aliases": ["D-galacturonate formation", "D-galacturonate synthesis", "D-galacturonate anabolism", "D-galacturonate biosynthesis"], "types": ["T044"], "canonical_name": "D-galacturonate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. [GOC:jsg, GOC:mah]"}
{"concept_id": "C2246905", "aliases": [], "types": ["T039"], "canonical_name": "gas homeostasis", "definition": "A homeostatic process involved in the maintenance of an internal steady state of a gas within an organism or cell. [GOC:mah]"}
{"concept_id": "C2246906", "aliases": ["NO homeostasis"], "types": ["T039"], "canonical_name": "nitric oxide homeostasis", "definition": "A homeostatic process involved in the maintenance of an internal steady state of nitric oxide within an organism or cell. [GOC:mah]"}
{"concept_id": "C2246907", "aliases": ["cyanidin 3-O-glucoside formation", "cyanidin 3-O-glucoside synthesis", "cyanidin 3-O-glucoside biosynthesis", "cyanidin 3-O-glucoside anabolism"], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits. [GOC:mah, MetaCyc:PWY-5125]"}
{"concept_id": "C2246908", "aliases": ["delphinidin 3-O-glucoside biosynthesis", "delphinidin 3-O-glucoside synthesis", "delphinidin 3-O-glucoside formation", "delphinidin 3-O-glucoside anabolism"], "types": ["T044"], "canonical_name": "delphinidin 3-O-glucoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits. [GOC:mah, MetaCyc:PWY-5153]"}
{"concept_id": "C2246909", "aliases": ["pelargonidin 3-O-glucoside anabolism", "pelargonidin 3-O-glucoside synthesis", "pelargonidin 3-O-glucoside formation", "pelargonidin 3-O-glucoside biosynthesis"], "types": ["T044"], "canonical_name": "pelargonidin 3-O-glucoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pelargonidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits. [GOC:mah, MetaCyc:PWY-5125]"}
{"concept_id": "C2246910", "aliases": ["cholesterol formation via 24,25-dihydrolanosterol", "cholesterol biosynthesis via 24,25-dihydrolanosterol", "cholesterol synthesis via 24,25-dihydrolanosterol", "cholesterol anabolism via 24,25-dihydrolanosterol"], "types": ["T044"], "canonical_name": "cholesterol biosynthetic process via 24,25-dihydrolanosterol", "definition": "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol. [GOC:mah, MetaCyc:PWY66-3]"}
{"concept_id": "C2246911", "aliases": ["cholesterol formation via desmosterol", "cholesterol anabolism via desmosterol", "cholesterol synthesis via desmosterol", "cholesterol biosynthesis via desmosterol"], "types": ["T044"], "canonical_name": "cholesterol biosynthetic process via desmosterol", "definition": "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol. [GOC:mah, MetaCyc:PWY66-4]"}
{"concept_id": "C2246912", "aliases": ["cholesterol anabolism via lathosterol", "cholesterol synthesis via lathosterol", "cholesterol formation via lathosterol", "cholesterol biosynthesis via lathosterol"], "types": ["T044"], "canonical_name": "cholesterol biosynthetic process via lathosterol", "definition": "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol. [GOC:mah, MetaCyc:PWY66-341]"}
{"concept_id": "C2246913", "aliases": ["coniferin metabolism"], "types": ["T044"], "canonical_name": "coniferin metabolic process", "definition": "The chemical reactions and pathways involving coniferin, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside. [GOC:mah, MetaCyc:PWY-116]"}
{"concept_id": "C2246914", "aliases": ["esculetin metabolism"], "types": ["T044"], "canonical_name": "esculetin metabolic process", "definition": "The chemical reactions and pathways involving esculetin, 6,7-dihydroxycoumarin. [GOC:mah]"}
{"concept_id": "C2246915", "aliases": ["esculetin biosynthesis", "esculetin formation", "esculetin anabolism", "esculetin synthesis"], "types": ["T044"], "canonical_name": "esculetin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of esculetin, 6,7-dihydroxycoumarin. [GOC:mah]"}
{"concept_id": "C2246916", "aliases": ["ferulate metabolism"], "types": ["T044"], "canonical_name": "ferulate metabolic process", "definition": "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate. [GOC:mah]"}
{"concept_id": "C2246917", "aliases": ["ferulate synthesis", "ferulate anabolism", "ferulate biosynthesis", "ferulate formation"], "types": ["T044"], "canonical_name": "ferulate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate. [GOC:mah]"}
{"concept_id": "C2246918", "aliases": ["sinapate metabolism"], "types": ["T044"], "canonical_name": "sinapate metabolic process", "definition": "The chemical reactions and pathways involving sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate. [GOC:mah]"}
{"concept_id": "C2246919", "aliases": ["sinapate anabolism", "sinapate synthesis", "sinapate formation", "sinapate biosynthesis"], "types": ["T044"], "canonical_name": "sinapate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate. [GOC:mah]"}
{"concept_id": "C2246920", "aliases": ["galactose breakdown via D-galactonate", "galactose catabolism via D-galactonate", "galactose degradation via D-galactonate"], "types": ["T044"], "canonical_name": "galactose catabolic process via D-galactonate", "definition": "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate. [GOC:mah, MetaCyc:GALDEG-PWY]"}
{"concept_id": "C2246921", "aliases": ["galactose breakdown via UDP-galactose", "galactose degradation via UDP-galactose", "galactose catabolism via UDP-galactose"], "types": ["T044"], "canonical_name": "galactose catabolic process via UDP-galactose", "definition": "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose. [GOC:mah, MetaCyc:PWY-3821]"}
{"concept_id": "C2246922", "aliases": [], "types": ["T039"], "canonical_name": "carbohydrate homeostasis", "definition": "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. [GOC:mah]"}
{"concept_id": "C2246923", "aliases": [], "types": ["T039"], "canonical_name": "galactose homeostasis", "definition": "A homeostatic process involved in the maintenance of an internal steady state of galactose within an organism or cell. [GOC:mah]"}
{"concept_id": "C2246924", "aliases": ["cell galactose homeostasis"], "types": ["T043"], "canonical_name": "cellular galactose homeostasis", "definition": "A cellular homeostatic process involved in the maintenance of an internal steady state of galactose within a cell or between a cell and its external environment. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2246925", "aliases": ["HULC complex location"], "types": ["T026"], "canonical_name": "HULC complex", "definition": "A ubiquitin ligase complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp6, Shf1, Brl2/Rfp1 and Brl1/Rfp2. [GOC:mah, PMID:17363370, PMID:17374714]"}
{"concept_id": "C2246926", "aliases": [], "types": ["T042"], "canonical_name": "floor plate development", "definition": "The progression of the floor plate over time from its initial formation until its mature state. [GOC:dh]"}
{"concept_id": "C2246927", "aliases": [], "types": ["T042"], "canonical_name": "floor plate morphogenesis", "definition": "The process in which the anatomical structure of the floor plate is generated and organized. [GOC:dh]"}
{"concept_id": "C2246928", "aliases": ["glucosinolate anabolism from homomethionine", "glucosinolate biosynthesis from homomethionine", "glucosinolate synthesis from homomethionine", "glucosinolate formation from homomethionine"], "types": ["T044"], "canonical_name": "glucosinolate biosynthetic process from homomethionine", "definition": "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including homomethionine. [GOC:mah, MetaCyc:PWY-1187]"}
{"concept_id": "C2246929", "aliases": ["glucosinolate anabolism from phenylalanine", "glucosinolate biosynthesis from phenylalanine", "glucosinolate formation from phenylalanine", "glucosinolate synthesis from phenylalanine"], "types": ["T044"], "canonical_name": "glucosinolate biosynthetic process from phenylalanine", "definition": "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including phenylalanine. [GOC:mah, MetaCyc:PWY-2821]"}
{"concept_id": "C2246930", "aliases": ["glutamate breakdown to butyrate", "glutamate degradation to butyrate"], "types": ["T044"], "canonical_name": "glutamate catabolic process to butyrate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate. [GOC:mah, MetaCyc:PWY-5087]"}
{"concept_id": "C2246931", "aliases": ["glutamate degradation to propionate", "glutamate breakdown to propionate"], "types": ["T044"], "canonical_name": "glutamate catabolic process to propionate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including propionate. [GOC:mah, MetaCyc:PWY-5088]"}
{"concept_id": "C2246932", "aliases": ["luteolin metabolism"], "types": ["T044"], "canonical_name": "luteolin metabolic process", "definition": "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one. [GOC:mah]"}
{"concept_id": "C2246933", "aliases": ["luteolin biosynthesis", "luteolin formation", "luteolin synthesis", "luteolin anabolism"], "types": ["T044"], "canonical_name": "luteolin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one. [GOC:mah]"}
{"concept_id": "C2246934", "aliases": ["L-lysine breakdown to acetyl-CoA via saccharopine", "L-lysine degradation to acetyl-CoA via saccharopine"], "types": ["T044"], "canonical_name": "L-lysine catabolic process to acetyl-CoA via saccharopine", "definition": "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine. [GOC:mah, MetaCyc:LYSINE-DEG1-PWY]"}
{"concept_id": "C2246935", "aliases": ["L-lysine breakdown to acetyl-CoA via 5-aminopentanamide", "L-lysine degradation to acetyl-CoA via 5-aminopentanamide"], "types": ["T044"], "canonical_name": "L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide", "definition": "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide. [GOC:mah, MetaCyc:PWY-5280]"}
{"concept_id": "C2246936", "aliases": ["L-lysine breakdown to acetyl-CoA via L-pipecolate", "L-lysine degradation to acetyl-CoA via L-pipecolate"], "types": ["T044"], "canonical_name": "L-lysine catabolic process to acetyl-CoA via L-pipecolate", "definition": "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate. [GOC:mah, MetaCyc:PWY-5283]"}
{"concept_id": "C2246937", "aliases": ["L-lysine breakdown using lysine 6-aminotransferase", "L-lysine degradation using lysine 6-aminotransferase"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase. [GOC:mah, MetaCyc:PWY-5298]", "canonical_name": "L-lysine catabolic process using lysine 6-aminotransferase"}
{"concept_id": "C2246938", "aliases": ["L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine", "L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine", "methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine", "L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine"], "types": ["T044"], "canonical_name": "L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine", "definition": "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine. [GOC:mah, MetaCyc:PWY-702]"}
{"concept_id": "C2246939", "aliases": ["phytate metabolic process", "phytate metabolism", "myo-inositol hexakisphosphate metabolism"], "types": ["T044"], "canonical_name": "myo-inositol hexakisphosphate metabolic process", "definition": "The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds. [PMID:16107538]"}
{"concept_id": "C2246940", "aliases": ["phytate dephosphorylation"], "types": ["T044"], "canonical_name": "myo-inositol hexakisphosphate dephosphorylation", "definition": "The process of removing one or more phosphate group from myo-inositol hexakisphosphate. [GOC:mah]"}
{"concept_id": "C2246941", "aliases": ["phytyl diphosphate metabolism"], "types": ["T044"], "canonical_name": "phytyl diphosphate metabolic process", "definition": "The chemical reactions and pathways involving phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate. [GOC:mah]"}
{"concept_id": "C2246942", "aliases": ["phytol anabolism", "phytol formation", "phytol synthesis", "phytol biosynthesis"], "types": ["T044"], "canonical_name": "phytol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol. [GOC:mah]"}
{"concept_id": "C2246943", "aliases": ["phytyl diphosphate synthesis", "phytyl diphosphate formation", "phytyl diphosphate biosynthesis", "phytyl diphosphate anabolism"], "types": ["T044"], "canonical_name": "phytyl diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate. [GOC:mah]"}
{"concept_id": "C2246944", "aliases": [], "types": ["T044"], "canonical_name": "histone H2A ubiquitination", "definition": "The modification of histone H2A by addition of one or more ubiquitin groups. [GOC:bf, GOC:mah, PMID:15509584, PMID:16473935, PMID:18430235]"}
{"concept_id": "C2246945", "aliases": [], "types": ["T044"], "canonical_name": "histone H2B ubiquitination", "definition": "The modification of histone H2B by addition of ubiquitin groups. [GOC:mah]"}
{"concept_id": "C2246946", "aliases": ["sinapate ester metabolism"], "types": ["T044"], "canonical_name": "sinapate ester metabolic process", "definition": "The chemical reactions and pathways involving ester derivatives of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate. [GOC:mah]"}
{"concept_id": "C2246947", "aliases": ["sinapate ester anabolism", "sinapate ester formation", "sinapate ester synthesis", "sinapate ester biosynthesis"], "types": ["T044"], "canonical_name": "sinapate ester biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate. [GOC:mah]"}
{"concept_id": "C2246948", "aliases": ["tetrapyrrole anabolism from glutamate", "tetrapyrrole biosynthesis from glutamate", "tetrapyrrole synthesis from glutamate", "tetrapyrrole formation from glutamate"], "types": ["T044"], "canonical_name": "tetrapyrrole biosynthetic process from glutamate", "definition": "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate. [GOC:mah, MetaCyc:PWY-5188]"}
{"concept_id": "C2246949", "aliases": ["tetrapyrrole formation from glycine and succinyl-CoA", "tetrapyrrole synthesis from glycine and succinyl-CoA", "tetrapyrrole biosynthesis from glycine and succinyl-CoA", "tetrapyrrole anabolism from glycine and succinyl-CoA"], "types": ["T044"], "canonical_name": "tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "definition": "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA. [GOC:mah, MetaCyc:PWY-5189]"}
{"concept_id": "C2246950", "aliases": [], "types": ["T044"], "canonical_name": "S-methylmethionine cycle", "definition": "A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level. [GOC:mah, MetaCyc:PWY-5441]"}
{"concept_id": "C2246951", "aliases": ["raffinose synthesis", "raffinose formation", "raffinose anabolism", "raffinose biosynthesis"], "types": ["T044"], "canonical_name": "raffinose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. [GOC:mah]"}
{"concept_id": "C2246952", "aliases": ["raffinose metabolism"], "types": ["T044"], "canonical_name": "raffinose metabolic process", "definition": "The chemical reactions and pathways involving raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. [GOC:mah]"}
{"concept_id": "C2246953", "aliases": ["stachyose metabolism"], "types": ["T044"], "canonical_name": "stachyose metabolic process", "definition": "The chemical reactions and pathways involving stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. [GOC:mah]"}
{"concept_id": "C2246954", "aliases": ["stachyose anabolism", "stachyose biosynthesis", "stachyose synthesis", "stachyose formation"], "types": ["T044"], "canonical_name": "stachyose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. [GOC:mah]"}
{"concept_id": "C2246955", "aliases": ["verbascose metabolism"], "types": ["T044"], "canonical_name": "verbascose metabolic process", "definition": "The chemical reactions and pathways involving verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. [GOC:mah, MetaCyc:CPD-8065]"}
{"concept_id": "C2246956", "aliases": ["verbascose formation", "verbascose biosynthesis", "verbascose synthesis", "verbascose anabolism"], "types": ["T044"], "canonical_name": "verbascose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. [GOC:mah, MetaCyc:CPD-8065]"}
{"concept_id": "C2246957", "aliases": ["ajugose metabolism"], "types": ["T044"], "canonical_name": "ajugose metabolic process", "definition": "The chemical reactions and pathways involving ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. [GOC:mah, MetaCyc:CPD-8066]"}
{"concept_id": "C2246958", "aliases": ["ajugose formation", "ajugose biosynthesis", "ajugose anabolism", "ajugose synthesis"], "types": ["T044"], "canonical_name": "ajugose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. [GOC:mah, MetaCyc:CPD-8066]"}
{"concept_id": "C2246959", "aliases": ["ajugose formation using galactinol:raffinose galactosyltransferase", "ajugose anabolism using galactinol:raffinose galactosyltransferase", "ajugose biosynthesis using galactinol:raffinose galactosyltransferase", "ajugose synthesis using galactinol:raffinose galactosyltransferase"], "types": ["T044"], "canonical_name": "ajugose biosynthetic process using galactinol:raffinose galactosyltransferase", "definition": "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide. [GOC:mah, MetaCyc:PWY-5342]"}
{"concept_id": "C2246960", "aliases": ["ajugose synthesis using galactan:galactan galactosyltransferase", "ajugose formation using galactan:galactan galactosyltransferase", "ajugose biosynthesis using galactan:galactan galactosyltransferase", "ajugose anabolism using galactan:galactan galactosyltransferase"], "types": ["T044"], "canonical_name": "ajugose biosynthetic process using galactan:galactan galactosyltransferase", "definition": "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another. [GOC:mah, MetaCyc:PWY-5343]"}
{"concept_id": "C2246961", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid beta-oxidation using acyl-CoA dehydrogenase", "definition": "A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]"}
{"concept_id": "C2246962", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid beta-oxidation using acyl-CoA oxidase", "definition": "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, MetaCyc:PWY-5136]"}
{"concept_id": "C2246963", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid beta-oxidation, unsaturated, odd number", "definition": "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, MetaCyc:PWY-5137]"}
{"concept_id": "C2246964", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid beta-oxidation, unsaturated, even number", "definition": "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, MetaCyc:PWY-5138]"}
{"concept_id": "C2246965", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway", "definition": "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, MetaCyc:PWY-5138]"}
{"concept_id": "C2246966", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid beta-oxidation, unsaturated, even number, epimerase pathway", "definition": "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, MetaCyc:PWY-5138]"}
{"concept_id": "C2246967", "aliases": ["myo-inositol hexakisphosphate synthesis, lipid-dependent", "phytate biosynthetic process, lipid-dependent", "myo-inositol hexakisphosphate formation, lipid-dependent", "phytate biosynthesis, lipid-dependent", "myo-inositol hexakisphosphate anabolism, lipid-dependent", "myo-inositol hexakisphosphate biosynthesis, lipid-dependent"], "types": ["T044"], "canonical_name": "myo-inositol hexakisphosphate biosynthetic process, lipid-dependent", "definition": "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C. [GOC:mah, MetaCyc:PWY-6555]"}
{"concept_id": "C2246968", "aliases": ["phytate biosynthesis, via inositol 1,3,4-trisphosphate", "myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate", "myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate", "myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate", "phytate biosynthetic process, via inositol 1,3,4-trisphosphate", "myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate"], "types": ["T044"], "canonical_name": "myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate", "definition": "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further. [GOC:mah, MetaCyc:PWY-6554]"}
{"concept_id": "C2246970", "aliases": ["phytate biosynthesis, lipid-independent", "myo-inositol hexakisphosphate synthesis, lipid-independent", "myo-inositol hexakisphosphate biosynthesis, lipid-independent", "myo-inositol hexakisphosphate formation, lipid-independent", "myo-inositol hexakisphosphate anabolism, lipid-independent", "phytate biosynthetic process, lipid-independent"], "types": ["T044"], "canonical_name": "myo-inositol hexakisphosphate biosynthetic process, lipid-independent", "definition": "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate. [GOC:mah, MetaCyc:PWY-4661]"}
{"concept_id": "C2246971", "aliases": ["tyrosine-specific MAP kinase phosphatase activity"], "types": ["T044"], "canonical_name": "MAP kinase tyrosine phosphatase activity", "definition": "Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate. [GOC:mah]"}
{"concept_id": "C2246972", "aliases": ["monopolin complex location"], "types": ["T026"], "canonical_name": "monopolin complex", "definition": "A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits. [GOC:mah, GOC:rb, PMID:17627824]"}
{"concept_id": "C2246973", "aliases": ["monopolin subcomplex Csm1/Lrs4 location"], "types": ["T026"], "canonical_name": "monopolin subcomplex Csm1/Lrs4"}
{"concept_id": "C2246974", "aliases": ["Pcs1/Mde4 complex location"], "types": ["T026"], "canonical_name": "Pcs1/Mde4 complex"}
{"concept_id": "C2246975", "aliases": [], "types": ["T043"], "canonical_name": "response to vitamin B3", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus. [GOC:sl]"}
{"concept_id": "C2246976", "aliases": [], "types": ["T043"], "canonical_name": "response to niacin"}
{"concept_id": "C2246977", "aliases": [], "types": ["T043"], "canonical_name": "response to nicotinamide"}
{"concept_id": "C2246978", "aliases": ["ribosomal DNA heterochromatin"], "types": ["T026"], "canonical_name": "rDNA heterochromatin", "definition": "A region of heterochromatin located at the rDNA repeats in a chromosome. [GOC:mah, PMID:20661445]"}
{"concept_id": "C2246979", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organismal response to stress", "definition": "Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mah]"}
{"concept_id": "C2246980", "aliases": ["dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity"], "types": ["T044"], "canonical_name": "dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity", "definition": "Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol. [GOC:mah, PMID:10336995]"}
{"concept_id": "C2246981", "aliases": ["Slx1-Slx4 complex location"], "types": ["T026"], "canonical_name": "Slx1-Slx4 complex", "definition": "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes. [PMID:14528010, PMID:16467377]"}
{"concept_id": "C2246982", "aliases": ["protein deacetylase activity"], "types": ["T044"], "canonical_name": "protein lysine deacetylase activity", "definition": "Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. [PMID:27296530, RHEA:58108]"}
{"concept_id": "C2246983", "aliases": ["unsaturated fatty acid metabolism"], "types": ["T044"], "canonical_name": "unsaturated fatty acid metabolic process", "definition": "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. [GOC:mah]"}
{"concept_id": "C2246984", "aliases": [], "types": ["T044"], "canonical_name": "folate reductase activity", "definition": "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+. [GOC:pde]"}
{"concept_id": "C2246985", "aliases": [], "types": ["T040"], "canonical_name": "regulation of water loss via skin", "definition": "A process that modulates the rate or extent of water loss from an organism via the skin. [GOC:mah]"}
{"concept_id": "C2246986", "aliases": [], "types": ["T042"], "canonical_name": "skin barrier function"}
{"concept_id": "C2246987", "aliases": ["cotranscriptional gene silencing by small RNA", "co-transcriptional gene silencing by small RNA", "small RNA-mediated cotranscriptional gene silencing", "RNAi-mediated CTGS"], "types": ["T045"], "canonical_name": "co-transcriptional gene silencing by RNA interference machinery", "definition": "A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin. [GOC:mah, GOC:vw, PMID:17512405, PMID:21151114, PMID:22431512]"}
{"concept_id": "C2246988", "aliases": ["dorsal/ventral axon pathfinding", "dorsal-ventral axon guidance", "dorsoventral axon guidance"], "types": ["T043"], "canonical_name": "dorsal/ventral axon guidance", "definition": "The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2246989", "aliases": ["anterior-posterior axon guidance", "anterior/posterior axon pathfinding"], "types": ["T043"], "canonical_name": "anterior/posterior axon guidance", "definition": "The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2246990", "aliases": ["Hrs/STAM complex location", "Vps27p-Hse1p complex location", "Hrs/STAM complex", "Vps27p-Hse1p complex", "ESCRT-0 complex location"], "types": ["T026"], "canonical_name": "ESCRT-0 complex", "definition": "A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals. [GOC:rb, PMID:12055639, PMID:17543868]"}
{"concept_id": "C2246991", "aliases": ["establishment and maintenance of gamma-tubulin complex localization", "gamma-tubulin complex localisation"], "types": ["T043"], "canonical_name": "gamma-tubulin complex localization", "definition": "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C2246992", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication, Okazaki fragment processing", "definition": "The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand. [GOC:mah, ISBN:0716720094]"}
{"concept_id": "C2246993", "aliases": [], "types": ["T044"], "canonical_name": "lactoferrin receptor activity", "definition": "Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH. [GOC:bf, GOC:mlg, PMID:16261254]"}
{"concept_id": "C2246994", "aliases": [], "types": ["T044"], "canonical_name": "lactoferrin transmembrane transporter activity", "definition": "Enables the transfer of lactoferrin from one side of a membrane to the other. [GOC:mlg]"}
{"concept_id": "C2246996", "aliases": [], "types": ["T043"], "canonical_name": "lactoferrin transport", "definition": "The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mlg]"}
{"concept_id": "C2246997", "aliases": ["melanotransferrin transport"], "types": ["T043"], "canonical_name": "transferrin transport", "definition": "The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mlg]"}
{"concept_id": "C2246998", "aliases": ["high affinity iron permease complex", "high-affinity iron permease complex location", "high affinity iron permease complex location"], "types": ["T026"], "canonical_name": "high-affinity iron permease complex", "definition": "A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:jp, PMID:16522632, PMID:8599111]"}
{"concept_id": "C2246999", "aliases": ["response to testosterone stimulus"], "types": ["T043"], "canonical_name": "response to testosterone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. [GOC:sl]"}
{"concept_id": "C2247008", "aliases": [], "types": ["T026"], "canonical_name": "rhabdomere membrane", "definition": "The portion of the plasma membrane surrounding the rhabdomere. [GOC:mah]"}
{"concept_id": "C2247009", "aliases": ["tyrosine synthesis from chorismate via L-arogenate", "tyrosine formation from chorismate via L-arogenate", "tyrosine anabolism from chorismate via L-arogenate"], "types": ["T044"], "canonical_name": "tyrosine biosynthetic process from chorismate via L-arogenate", "definition": "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate L-arogenate. [GOC:mah]"}
{"concept_id": "C2247010", "aliases": ["L-phenylalanine anabolism from chorismate via phenylpyruvate", "L-phenylalanine synthesis from chorismate via phenylpyruvate", "L-phenylalanine biosynthesis from chorismate via phenylpyruvate", "L-phenylalanine formation from chorismate via phenylpyruvate"], "types": ["T044"], "canonical_name": "L-phenylalanine biosynthetic process from chorismate via phenylpyruvate", "definition": "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate. [GOC:go_curators]"}
{"concept_id": "C2247011", "aliases": ["L-phenylalanine anabolism from chorismate via L-arogenate", "L-phenylalanine synthesis from chorismate via L-arogenate", "L-phenylalanine biosynthesis from chorismate via L-arogenate", "L-phenylalanine formation from chorismate via L-arogenate"], "types": ["T044"], "canonical_name": "L-phenylalanine biosynthetic process from chorismate via L-arogenate", "definition": "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate. [GOC:go_curators]"}
{"concept_id": "C2247013", "aliases": ["elongator holoenzyme complex location"], "types": ["T026"], "canonical_name": "elongator holoenzyme complex", "definition": "A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA. [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209]"}
{"concept_id": "C2247014", "aliases": ["Elongator core complex location"], "types": ["T026"], "canonical_name": "Elongator core complex"}
{"concept_id": "C2247015", "aliases": ["response to vitamin B12"], "types": ["T043"], "canonical_name": "response to cobalamin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus. [GOC:sl]"}
{"concept_id": "C2247016", "aliases": ["response to L-ascorbate", "response to vitamin C"], "types": ["T043"], "canonical_name": "response to L-ascorbic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus. [GOC:sl]"}
{"concept_id": "C2247017", "aliases": [], "types": ["T043"], "canonical_name": "response to ascorbic acid"}
{"concept_id": "C2247018", "aliases": [], "types": ["T045"], "canonical_name": "RNA strand annealing activity", "definition": "An activity that facilitates the formation of a complementary double-stranded RNA molecule. [GOC:mah, PMID:7543843]"}
{"concept_id": "C2247019", "aliases": ["BRCA2-MAGE-D1 complex location"], "types": ["T026"], "canonical_name": "BRCA2-MAGE-D1 complex", "definition": "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth. [PMID:15930293]"}
{"concept_id": "C2247020", "aliases": [], "types": ["T043"], "canonical_name": "response to hydroxyisoflavone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus. [GOC:mah]"}
{"concept_id": "C2247021", "aliases": [], "types": ["T043"], "canonical_name": "response to genistein", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus. [GOC:mah]"}
{"concept_id": "C2247022", "aliases": ["tuberin-hamartin complex location", "TSC1-TSC2 complex", "tuberin-hamartin complex", "TSC1-TSC2 complex location", "tuberous sclerosis complex location"], "types": ["T026"], "definition": "A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. [PMID:10585443, PMID:17121544, PMID:9580671]", "canonical_name": "tuberous sclerosis complex"}
{"concept_id": "C2247023", "aliases": ["mitotic checkpoint complex", "mitotic checkpoint complex location"], "types": ["T026"], "definition": "A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. [PMID:10704439, PMID:11535616, PMID:11726501, PMID:17650307]", "canonical_name": "MCC"}
{"concept_id": "C2247024", "aliases": [], "types": ["T043"], "canonical_name": "mammary gland epithelial cell proliferation", "definition": "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, GOC:mah]"}
{"concept_id": "C2247025", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mammary gland epithelial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. [GOC:mah]"}
{"concept_id": "C2247026", "aliases": ["down regulation of mammary gland epithelial cell proliferation", "downregulation of mammary gland epithelial cell proliferation", "down-regulation of mammary gland epithelial cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of mammary gland epithelial cell proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation. [GOC:mah]"}
{"concept_id": "C2247027", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mammary gland epithelial cell proliferation"}
{"concept_id": "C2247028", "aliases": ["up regulation of mammary gland epithelial cell proliferation", "upregulation of mammary gland epithelial cell proliferation", "up-regulation of mammary gland epithelial cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of mammary gland epithelial cell proliferation", "definition": "Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation. [GOC:mah]"}
{"concept_id": "C2247029", "aliases": [], "types": ["T043"], "canonical_name": "activation of mammary gland epithelial cell proliferation"}
{"concept_id": "C2247030", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mammary gland epithelial cell proliferation"}
{"concept_id": "C2247031", "aliases": ["downregulation of dopamine secretion", "down-regulation of dopamine secretion", "down regulation of dopamine secretion"], "types": ["T043"], "canonical_name": "negative regulation of dopamine secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine. [GOC:sl]"}
{"concept_id": "C2247032", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dopamine secretion"}
{"concept_id": "C2247033", "aliases": ["up regulation of dopamine secretion", "upregulation of dopamine secretion", "up-regulation of dopamine secretion"], "types": ["T043"], "canonical_name": "positive regulation of dopamine secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine. [GOC:sl]"}
{"concept_id": "C2247034", "aliases": [], "types": ["T043"], "canonical_name": "activation of dopamine secretion"}
{"concept_id": "C2247035", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of dopamine secretion"}
{"concept_id": "C2247036", "aliases": ["down regulation of catecholamine secretion", "downregulation of catecholamine secretion", "down-regulation of catecholamine secretion"], "types": ["T043"], "canonical_name": "negative regulation of catecholamine secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. [GOC:mah]"}
{"concept_id": "C2247037", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of catecholamine secretion"}
{"concept_id": "C2247038", "aliases": ["up-regulation of catecholamine secretion", "up regulation of catecholamine secretion", "upregulation of catecholamine secretion"], "types": ["T043"], "canonical_name": "positive regulation of catecholamine secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. [GOC:mah]"}
{"concept_id": "C2247039", "aliases": [], "types": ["T043"], "canonical_name": "activation of catecholamine secretion"}
{"concept_id": "C2247040", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of catecholamine secretion"}
{"concept_id": "C2247041", "aliases": ["chemokine receptor translocation within membrane"], "types": ["T043"], "canonical_name": "chemokine receptor transport within lipid bilayer", "definition": "The directed movement of a chemokine receptor within a lipid bilayer. [GOC:mah]"}
{"concept_id": "C2247042", "aliases": ["SOD1-Bcl-2 complex location"], "types": ["T026"], "canonical_name": "SOD1-Bcl-2 complex", "definition": "A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway. [PMID:15233914, PMID:16790527]"}
{"concept_id": "C2247043", "aliases": ["formyl-CoA oxalate CoA-transferase activity", "formyl-CoA:oxalate CoA-transferase activity", "formyl-coenzyme A transferase activity"], "types": ["T044"], "canonical_name": "formyl-CoA transferase activity", "definition": "Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA. [EC:2.8.3.16, RHEA:16545]"}
{"concept_id": "C2247044", "aliases": ["oxalate metabolism", "oxalic acid metabolic process", "ethanedioic acid metabolic process", "ethanedioate metabolic process"], "types": ["T044"], "canonical_name": "oxalate metabolic process", "definition": "The chemical reactions and pathways involving oxalate, the organic acid ethanedioate. [GOC:mlg]"}
{"concept_id": "C2247045", "aliases": ["oxalate synthesis", "ethanedioate biosynthetic process", "ethanedioic acid biosynthetic process", "oxalate anabolism", "oxalic acid biosynthetic process", "oxalate biosynthesis", "oxalate formation"], "types": ["T044"], "canonical_name": "oxalate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of oxalate, the organic acid ethanedioate. [GOC:mlg]"}
{"concept_id": "C2247046", "aliases": ["oxalate catabolism", "ethanedioic acid catabolic process", "oxalate degradation", "oxalic acid catabolic process", "oxalate breakdown", "ethanedioate catabolic process"], "types": ["T044"], "canonical_name": "oxalate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate. [GOC:mlg]"}
{"concept_id": "C2247047", "aliases": [], "types": ["T044"], "canonical_name": "receptor serine/threonine kinase binding", "definition": "Binding to a receptor that possesses protein serine/threonine kinase activity. [GOC:mah]"}
{"concept_id": "C2247048", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor protein serine/threonine kinase ligand binding"}
{"concept_id": "C2247050", "aliases": [], "types": ["T044"], "canonical_name": "chloroplast proton-transporting ATP synthase complex assembly", "definition": "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane. [GOC:mah]"}
{"concept_id": "C2247051", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial proton-transporting ATP synthase complex assembly", "definition": "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane. [GOC:mah]"}
{"concept_id": "C2247052", "aliases": [], "types": ["T044"], "canonical_name": "plasma membrane proton-transporting ATP synthase complex assembly", "definition": "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane. [GOC:mah]"}
{"concept_id": "C2247053", "aliases": ["mitochondrial cytochrome c oxidase complex assembly", "mitochondrial respiratory chain complex IV assembly"], "types": ["T044"], "canonical_name": "mitochondrial cytochrome c oxidase assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane. [GOC:mah]"}
{"concept_id": "C2247054", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial cytochrome c oxidase biogenesis"}
{"concept_id": "C2247055", "aliases": ["plasma membrane cytochrome c oxidase complex assembly"], "types": ["T044"], "canonical_name": "plasma membrane respiratory chain complex IV assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane. [GOC:mah]"}
{"concept_id": "C2247056", "aliases": [], "types": ["T044"], "canonical_name": "plasma membrane cytochrome c oxidase biogenesis"}
{"concept_id": "C2247057", "aliases": [], "types": ["T044"], "canonical_name": "membrane protein proteolysis", "definition": "The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. [GOC:pde]"}
{"concept_id": "C2247058", "aliases": ["Mei2 nuclear dot", "Mei2 nuclear dot complex location", "Mei2 dot"], "types": ["T026"], "canonical_name": "Mei2 nuclear dot complex", "definition": "A ribonucleoprotein complex that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I. [GOC:vw, PMID:12808043]"}
{"concept_id": "C2247059", "aliases": ["mRNA degradation, meiosis-specific transcripts", "mRNA catabolism, meiosis-specific transcripts", "mRNA breakdown, meiosis-specific transcripts", "nuclear mRNA catabolic process, meiosis-specific transcripts", "degradation of meiosis-specific transcripts"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts", "definition": "The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein. [PMID:16823445]"}
{"concept_id": "C2247060", "aliases": ["integrin complex assembly", "integrin complex activation"], "types": ["T043"], "canonical_name": "integrin activation", "definition": "The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands. [GOC:add, PMID:12213832, PMID:14754902]"}
{"concept_id": "C2247061", "aliases": ["regulation of integrin complex activation"], "types": ["T040"], "canonical_name": "regulation of integrin activation", "definition": "Any process that modulates the frequency, rate, or extent of integrin activation. [GOC:add]"}
{"concept_id": "C2247062", "aliases": ["negative regulation of integrin complex activation"], "types": ["T040"], "canonical_name": "negative regulation of integrin activation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation. [GOC:add]"}
{"concept_id": "C2247063", "aliases": ["positive regulation of integrin complex activation"], "types": ["T044"], "canonical_name": "positive regulation of integrin activation", "definition": "Any process that activates or increases the frequency, rate, or extent of integrin activation. [GOC:add]"}
{"concept_id": "C2247064", "aliases": ["cell surface receptor linked signal transduction leading to integrin complex activation", "cell surface receptor linked signal transduction leading to integrin activation"], "types": ["T044"], "canonical_name": "positive regulation of integrin activation by cell surface receptor linked signal transduction", "definition": "Any process that activates or increases the frequency, rate, or extent of integrin activation by cell surface receptor linked signal transduction. This can occur by increased affinity of an integrin for its extracellular ligands. [GOC:add, PMID:12213832, PMID:14754902]"}
{"concept_id": "C2247065", "aliases": ["regulation of cell adhesion mediated by integrin complex"], "types": ["T043"], "canonical_name": "regulation of cell adhesion mediated by integrin", "definition": "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]"}
{"concept_id": "C2247066", "aliases": ["negative regulation of cell adhesion mediated by integrin complex"], "types": ["T043"], "canonical_name": "negative regulation of cell adhesion mediated by integrin", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]"}
{"concept_id": "C2247067", "aliases": ["positive regulation of cell adhesion mediated by integrin complex"], "types": ["T043"], "canonical_name": "positive regulation of cell adhesion mediated by integrin", "definition": "Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]"}
{"concept_id": "C2247068", "aliases": ["cell-cell adhesion mediated by integrin complex"], "types": ["T043"], "canonical_name": "cell-cell adhesion mediated by integrin", "definition": "The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. [GOC:add, PMID:12213832, PMID:14754902]"}
{"concept_id": "C2247069", "aliases": ["regulation of cell-cell adhesion mediated by integrin complex"], "types": ["T043"], "canonical_name": "regulation of cell-cell adhesion mediated by integrin", "definition": "Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin. [GOC:add]"}
{"concept_id": "C2247070", "aliases": ["negative regulation of cell-cell adhesion mediated by integrin complex"], "types": ["T043"], "canonical_name": "negative regulation of cell-cell adhesion mediated by integrin", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin. [GOC:add]"}
{"concept_id": "C2247071", "aliases": ["positive regulation of cell-cell adhesion mediated by integrin complex"], "types": ["T043"], "canonical_name": "positive regulation of cell-cell adhesion mediated by integrin", "definition": "Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin. [GOC:add]"}
{"concept_id": "C2247072", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host response to abiotic stimulus", "definition": "Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247073", "aliases": ["modulation by symbiont of host response to thermal stimulus"], "types": ["T040"], "canonical_name": "modulation by symbiont of host response to temperature stimulus", "definition": "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247074", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host response to cold", "definition": "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247075", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host response to heat", "definition": "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247076", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host response to water", "definition": "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247077", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host response to osmotic stress", "definition": "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247078", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host response to pH", "definition": "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247079", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host response to gravitational stimulus", "definition": "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247080", "aliases": [], "types": ["T026"], "canonical_name": "host cell part", "definition": "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247081", "aliases": [], "types": ["T026"], "canonical_name": "host cell membrane", "definition": "Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247082", "aliases": [], "types": ["T026"], "canonical_name": "host cell endomembrane system", "definition": "A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247083", "aliases": ["host cell intracellular part"], "types": ["T026"], "canonical_name": "host intracellular part", "definition": "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247084", "aliases": [], "types": ["T026"], "canonical_name": "host intracellular organelle", "definition": "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247085", "aliases": ["host intracellular membrane-enclosed organelle"], "types": ["T026"], "canonical_name": "host intracellular membrane-bounded organelle", "definition": "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247086", "aliases": ["host mitochondria"], "types": ["T026"], "canonical_name": "host cell mitochondrion", "definition": "A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247087", "aliases": [], "types": ["T026"], "canonical_name": "host cell plastid", "definition": "Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247088", "aliases": [], "types": ["T026"], "canonical_name": "host cell chloroplast", "definition": "A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247089", "aliases": ["host chloroplast component"], "types": ["T026"], "canonical_name": "host cell chloroplast part", "definition": "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247090", "aliases": [], "types": ["T026"], "canonical_name": "host cell chloroplast thylakoid membrane", "definition": "Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247091", "aliases": [], "types": ["T026"], "canonical_name": "host cell cytoplasm part", "definition": "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247092", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host chloroplast", "definition": "The process in which an organism effects a change in the structure or function of host cell chloroplasts. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247093", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host chloroplast part", "definition": "The process in which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247094", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host chloroplast thylakoid", "definition": "The process in which an organism effects a change in the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247095", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host mitochondrion", "definition": "The process in which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247096", "aliases": ["down-regulation by symbiont of host gene-for-gene resistance", "negative regulation by symbiont of host resistance gene-dependent defense response", "downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont", "down regulation by symbiont of defense response in host by specific elicitors"], "types": ["T040"], "canonical_name": "suppression by symbiont of host resistance gene-dependent defense response", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247097", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host resistance gene-dependent defense response"}
{"concept_id": "C2247098", "aliases": ["down-regulation by organism of defense-related host oxidative burst", "negative regulation by organism of defense-related host ROS production", "down regulation by organism of defense-related host metabolic burst", "downregulation by organism of defense-related host AOS production", "negative regulation by organism of defense-related host ROI production", "negative regulation by organism of defense-related host reactive oxygen intermediate production", "negative regulation by symbiont of defense-related host reactive oxygen species production", "negative regulation by organism of defense-related host reactive oxidative species production", "negative regulation by organism of defense-related host respiratory burst"], "types": ["T040"], "canonical_name": "effector-mediated defense to host-produced reactive oxygen species", "definition": "A process mediated by a molecule secreted by a symbiont that results in the suppression of reactive oxygen species produced by the host as part of its innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247099", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by organism of defense-related host active oxygen species production"}
{"concept_id": "C2247110", "aliases": ["down regulation by organism of host apoptotic programmed cell death", "downregulation by organism of host apoptotic programmed cell death", "down-regulation by organism of host apoptotic programmed cell death"], "types": ["T040"], "canonical_name": "negative regulation by symbiont of host apoptotic process", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247111", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by organism of host apoptotic programmed cell death"}
{"concept_id": "C2247112", "aliases": ["regulation of NAD kinase activity"], "types": ["T044"], "canonical_name": "regulation of NAD+ kinase activity", "definition": "Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule. [GOC:mah]"}
{"concept_id": "C2247113", "aliases": [], "types": ["T044"], "canonical_name": "NAD kinase regulator"}
{"concept_id": "C2247114", "aliases": ["down-regulation of NAD+ kinase activity", "down regulation of NAD+ kinase activity", "downregulation of NAD+ kinase activity"], "types": ["T044"], "canonical_name": "negative regulation of NAD+ kinase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule. [GOC:mah]"}
{"concept_id": "C2247115", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of NAD+ kinase activity"}
{"concept_id": "C2247116", "aliases": [], "types": ["T044"], "canonical_name": "NAD+ kinase inhibitor"}
{"concept_id": "C2247117", "aliases": ["upregulation of NAD+ kinase activity", "up-regulation of NAD+ kinase activity", "up regulation of NAD+ kinase activity"], "types": ["T044"], "canonical_name": "positive regulation of NAD+ kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule. [GOC:mah]"}
{"concept_id": "C2247118", "aliases": [], "types": ["T044"], "canonical_name": "NAD+ kinase activator"}
{"concept_id": "C2247119", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of NAD+ kinase activity"}
{"concept_id": "C2247120", "aliases": ["downregulation of kinase activity", "down regulation of kinase activity", "down-regulation of kinase activity"], "types": ["T044"], "canonical_name": "negative regulation of kinase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah]"}
{"concept_id": "C2247121", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of kinase activity"}
{"concept_id": "C2247122", "aliases": ["up-regulation of kinase activity", "upregulation of kinase activity", "up regulation of kinase activity"], "types": ["T044"], "canonical_name": "positive regulation of kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah]"}
{"concept_id": "C2247123", "aliases": [], "types": ["T044"], "canonical_name": "kinase activator"}
{"concept_id": "C2247124", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of kinase activity"}
{"concept_id": "C2247125", "aliases": [], "types": ["T026"], "canonical_name": "pericanalicular vesicle", "definition": "A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes. [PMID:15763347, PMID:9790571]"}
{"concept_id": "C2247127", "aliases": ["ATP-dependent DNA/RNA helicase activity"], "types": ["T045"], "canonical_name": "DNA/RNA helicase activity", "definition": "Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis. [GOC:mah]"}
{"concept_id": "C2247128", "aliases": ["ATP-dependent 5'-3' DNA/RNA helicase activity", "ATP-dependent 5' to 3' DNA/RNA helicase activity", "5' to 3' DNA/RNA helicase activity"], "types": ["T045"], "canonical_name": "5'-3' DNA/RNA helicase activity", "definition": "Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis. [GOC:mah]"}
{"concept_id": "C2247129", "aliases": ["ATP-dependent 3'-5' DNA/RNA helicase activity", "ATP-dependent 3' to 5' DNA/RNA helicase activity", "3' to 5' DNA/RNA helicase activity"], "types": ["T045"], "canonical_name": "3'-5' DNA/RNA helicase activity", "definition": "Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis. [GOC:mah]"}
{"concept_id": "C2247133", "aliases": ["nucleic acid cleavage involved in nucleotide-excision repair", "DNA incision involved in nucleotide-excision repair"], "types": ["T045"], "canonical_name": "nucleotide-excision repair, DNA incision", "definition": "A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. [GOC:elh, PMID:8631896]"}
{"concept_id": "C2247134", "aliases": [], "types": ["T043"], "canonical_name": "regulation of luteinizing hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone. [GOC:mah]"}
{"concept_id": "C2247135", "aliases": ["down regulation of luteinizing hormone secretion", "down-regulation of luteinizing hormone secretion", "downregulation of luteinizing hormone secretion"], "types": ["T043"], "canonical_name": "negative regulation of luteinizing hormone secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone. [GOC:mah]"}
{"concept_id": "C2247136", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of luteinizing hormone secretion"}
{"concept_id": "C2247137", "aliases": ["upregulation of luteinizing hormone secretion", "up regulation of luteinizing hormone secretion", "up-regulation of luteinizing hormone secretion"], "types": ["T043"], "canonical_name": "positive regulation of luteinizing hormone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone. [GOC:mah]"}
{"concept_id": "C2247138", "aliases": [], "types": ["T039"], "canonical_name": "activation of luteinizing hormone secretion"}
{"concept_id": "C2247139", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of luteinizing hormone secretion"}
{"concept_id": "C2247140", "aliases": [], "types": ["T043"], "canonical_name": "osteoblast proliferation", "definition": "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone. [GOC:mah]"}
{"concept_id": "C2247141", "aliases": [], "types": ["T043"], "canonical_name": "regulation of osteoblast proliferation", "definition": "Any process that modulates the frequency, rate or extent of osteoblast proliferation. [GOC:mah]"}
{"concept_id": "C2247142", "aliases": ["downregulation of osteoblast proliferation", "down regulation of osteoblast proliferation", "down-regulation of osteoblast proliferation"], "types": ["T043"], "canonical_name": "negative regulation of osteoblast proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation. [GOC:mah]"}
{"concept_id": "C2247143", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of osteoblast proliferation"}
{"concept_id": "C2247144", "aliases": ["up-regulation of osteoblast proliferation", "upregulation of osteoblast proliferation", "up regulation of osteoblast proliferation"], "types": ["T043"], "canonical_name": "positive regulation of osteoblast proliferation", "definition": "Any process that activates or increases the rate or extent of osteoblast proliferation. [GOC:mah]"}
{"concept_id": "C2247145", "aliases": [], "types": ["T043"], "canonical_name": "activation of osteoblast proliferation"}
{"concept_id": "C2247146", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of osteoblast proliferation"}
{"concept_id": "C2247147", "aliases": [], "types": ["T044"], "canonical_name": "sialic acid binding", "definition": "Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria. [GOC:add, ISBN:9780721601465]"}
{"concept_id": "C2247148", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylneuraminic acid binding"}
{"concept_id": "C2247149", "aliases": ["cellular glycan biosynthetic process", "cellular polysaccharide synthesis", "cellular polysaccharide formation", "cellular glycan biosynthesis", "cellular polysaccharide biosynthesis", "cellular polysaccharide anabolism"], "types": ["T044"], "canonical_name": "cellular polysaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell. [GOC:go_curators]"}
{"concept_id": "C2247150", "aliases": ["NF bundle assembly"], "types": ["T043"], "canonical_name": "neurofilament bundle assembly", "definition": "The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules. [PMID:11034913, PMID:11264295]"}
{"concept_id": "C2247151", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:jl]"}
{"concept_id": "C2247152", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule. [EC:1.17.5.-, GOC:mah]"}
{"concept_id": "C2247153", "aliases": ["negative regulation of extent of heterochromatin formation"], "types": ["T043"], "canonical_name": "negative regulation of extent of heterochromatin assembly"}
{"concept_id": "C2247154", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of heterochromatin boundaries"}
{"concept_id": "C2247155", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of heterochromatin spreading"}
{"concept_id": "C2247158", "aliases": ["Clr6 histone deacetylase complex I/I'", "Rpd3C(L)", "Rpd3L complex location", "Clr6L complex", "Clr6 histone deacetylase complex I/I' location", "Clr6L complex location"], "types": ["T026"], "canonical_name": "Rpd3L complex", "definition": "A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae). [GOC:vw, PMID:17450151]"}
{"concept_id": "C2247159", "aliases": ["DNA 5'-adenylate hydrolase activity"], "types": ["T045"], "canonical_name": "DNA 5'-adenosine monophosphate hydrolase activity", "definition": "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus. [GOC:mah, PMID:16547001, PMID:17276982]"}
{"concept_id": "C2247160", "aliases": [], "types": ["T045"], "canonical_name": "AMP-removal activity"}
{"concept_id": "C2247161", "aliases": [], "types": ["T045"], "canonical_name": "DNA adenylate hydrolysis activity"}
{"concept_id": "C2247162", "aliases": ["DNA deadenylation"], "types": ["T045"], "canonical_name": "DNA de-adenylation"}
{"concept_id": "C2247163", "aliases": ["phospholipid export"], "types": ["T043"], "canonical_name": "phospholipid efflux", "definition": "The directed movement of a phospholipid out of a cell or organelle. [GOC:mah]"}
{"concept_id": "C2247164", "aliases": ["dTDP-D-galactose:NADP+ 6-oxidoreductase activity", "dTDPgalactose 6-dehydrogenase activity", "thymidine-diphosphate-galactose dehydrogenase activity"], "types": ["T044"], "canonical_name": "dTDP-galactose 6-dehydrogenase activity", "definition": "Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+. [EC:1.1.1.186]"}
{"concept_id": "C2247165", "aliases": ["(+)-trans-carveol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(+)-trans-carveol dehydrogenase activity", "definition": "Catalysis of the reaction: (1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH. [EC:1.1.1.275, RHEA:14825]"}
{"concept_id": "C2247166", "aliases": ["3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity", "3beta-hydroxysteroid 5beta-oxidoreductase activity", "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity"], "types": ["T044"], "canonical_name": "3beta-hydroxy-5beta-steroid dehydrogenase activity", "definition": "Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH. [EC:1.1.1.277, RHEA:22944]"}
{"concept_id": "C2247167", "aliases": ["3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity"], "types": ["T044"], "canonical_name": "3beta-hydroxy-5alpha-steroid dehydrogenase activity", "definition": "Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH. [EC:1.1.1.278, RHEA:18137]"}
{"concept_id": "C2247168", "aliases": ["GDP-6-deoxy-D-lyxo-4-hexulose reductase activity", "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity", "Rmd"], "types": ["T044"], "definition": "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. [EC:1.1.1.281]", "canonical_name": "GDP-4-dehydro-6-deoxy-D-mannose reductase activity"}
{"concept_id": "C2247171", "aliases": ["2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity"], "types": ["T044"], "canonical_name": "3''-deamino-3''-oxonicotianamine reductase activity", "definition": "Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+. [EC:1.1.1.285]"}
{"concept_id": "C2247172", "aliases": ["homoisocitrate-isocitrate dehydrogenase activity", "PH1722", "isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity"], "types": ["T044"], "canonical_name": "isocitrate-homoisocitrate dehydrogenase activity", "definition": "Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+. [EC:1.1.1.286]"}
{"concept_id": "C2247173", "aliases": ["D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity", "ARD1p"], "types": ["T044"], "canonical_name": "D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity", "definition": "Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+. [EC:1.1.1.287]"}
{"concept_id": "C2247174", "aliases": ["D-arabinitol dehydrogenase 1 activity"], "types": ["T044"], "canonical_name": "D-arabinitol dehydrogenase 1 activity"}
{"concept_id": "C2247175", "aliases": ["4-O-phosphoerythronate dehydrogenase activity", "4PE dehydrogenase activity", "PdxB", "PdxB 4PE dehydrogenase activity", "erythronate-4-phosphate dehydrogenase activity", "4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "4-phosphoerythronate dehydrogenase activity", "definition": "Catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH. [EC:1.1.1.290, RHEA:18829]"}
{"concept_id": "C2247176", "aliases": [], "types": ["T044"], "canonical_name": "choline:oxygen 1-oxidoreductase activity", "definition": "Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide. [EC:1.1.3.17, RHEA:13505]"}
{"concept_id": "C2247177", "aliases": ["choline oxidase activity"], "types": ["T044"], "canonical_name": "choline oxidase activity"}
{"concept_id": "C2247178", "aliases": ["nucleoside:oxygen 5'-oxidoreductase activity"], "types": ["T044"], "canonical_name": "nucleoside oxidase activity", "definition": "Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O. [EC:1.1.3.28, RHEA:28651]"}
{"concept_id": "C2247179", "aliases": ["nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity"], "types": ["T044"], "canonical_name": "nucleoside oxidase (hydrogen peroxide-forming) activity", "definition": "Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide. [EC:1.1.3.39, RHEA:15489]"}
{"concept_id": "C2247180", "aliases": ["gluconic acid dehydrogenase activity", "gluconate oxidase activity", "D-gluconate dehydrogenase activity", "gluconic dehydrogenase activity", "D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity", "D-gluconate:(acceptor) 2-oxidoreductase activity", "D-gluconate:acceptor 2-oxidoreductase activity"], "types": ["T044"], "canonical_name": "gluconate 2-dehydrogenase (acceptor) activity", "definition": "Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor. [EC:1.1.99.3]"}
{"concept_id": "C2247183", "aliases": ["aldehyde:NADP+ oxidoreductase activity", "NADP-dependent aldehyde dehydrogenase activity", "NADP-acetaldehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "aldehyde dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+. [EC:1.2.1.4]"}
{"concept_id": "C2247184", "aliases": ["malonic semialdehyde dehydrogenase activity", "3-oxopropanoate:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "malonate-semialdehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+. [EC:1.2.1.15]"}
{"concept_id": "C2247185", "aliases": ["fluoroacetaldehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "fluoroacetaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+. [EC:1.2.1.69]"}
{"concept_id": "C2247186", "aliases": ["aldehyde:ferredoxin oxidoreductase activity", "AOR", "tungsten-containing aldehyde ferredoxin oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin. [EC:1.2.7.5]", "canonical_name": "aldehyde ferredoxin oxidoreductase activity"}
{"concept_id": "C2247187", "aliases": ["aldehyde:acceptor oxidoreductase (FAD-independent) activity", "aldehyde dehydrogenase (FAD-independent) activity", "aldehyde oxidoreductase activity", "Mop"], "types": ["T044"], "definition": "Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor. [EC:1.2.99.7]", "canonical_name": "AORDd"}
{"concept_id": "C2247188", "aliases": ["4VCR", "chlorophyllide-a:NADP+ oxidoreductase activity", "[4-vinyl]chlorophyllide a reductase activity"], "types": ["T044"], "canonical_name": "divinyl chlorophyllide a 8-vinyl-reductase activity", "definition": "Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+. [EC:1.3.1.75]"}
{"concept_id": "C2247189", "aliases": ["AtANR", "ANR", "MtANR", "flavan-3-ol:NAD(P)+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "anthocyanidin reductase activity", "definition": "Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+. [EC:1.3.1.77]"}
{"concept_id": "C2247190", "aliases": ["L-arogenate:NADP+ oxidoreductase (decarboxylating) activity", "TyrAa"], "types": ["T044"], "canonical_name": "arogenate dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2. [EC:1.3.1.78]"}
{"concept_id": "C2247193", "aliases": [], "types": ["T044"], "canonical_name": "TyrAAT1"}
{"concept_id": "C2247194", "aliases": [], "types": ["T044"], "canonical_name": "TyrAAT2"}
{"concept_id": "C2247195", "aliases": ["L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity"], "types": ["T044"], "canonical_name": "arogenate dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2. [EC:1.3.1.79]"}
{"concept_id": "C2247196", "aliases": ["PqqC", "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity"], "types": ["T044"], "canonical_name": "pyrroloquinoline-quinone synthase activity", "definition": "Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 2 H(2)O + 2 H(2)O(2) + H(+) + pyrroloquinoline quinone. [EC:1.3.3.11, RHEA:10692]"}
{"concept_id": "C2247197", "aliases": ["BbsG", "(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity", "(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "(R)-benzylsuccinyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein. [EC:1.3.8.3]"}
{"concept_id": "C2247198", "aliases": ["L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity", "NADP+-dependent aspartate dehydrogenase activity", "NAD-dependent aspartate dehydrogenase activity", "NADH2-dependent aspartate dehydrogenase activity"], "types": ["T044"], "canonical_name": "aspartate dehydrogenase activity", "definition": "Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+. [EC:1.4.1.21]"}
{"concept_id": "C2247199", "aliases": ["LodA", "Lod", "L-lysine-epsilon-oxidase activity", "L-lysine:oxygen 6-oxidoreductase (deaminating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-lysine + H(2)O + O(2) = allysine + H(2)O(2) + NH(4)(+). [EC:1.4.3.20, RHEA:22548]", "canonical_name": "L-lysine 6-oxidase activity"}
{"concept_id": "C2247200", "aliases": [], "types": ["T044"], "canonical_name": "marinocine"}
{"concept_id": "C2247201", "aliases": ["gamma-aminobutyraldehyde dehydrogenase activity", "YdcW", "1-pyrroline:NAD+ oxidoreductase activity", "ABALDH"], "types": ["T044"], "canonical_name": "1-pyrroline dehydrogenase activity", "definition": "Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+. [MetaCyc:1.5.1.35-RXN]"}
{"concept_id": "C2247202", "aliases": ["5-methyltetrahydrofolate:ferredoxin oxidoreductase activity"], "types": ["T044"], "canonical_name": "methylenetetrahydrofolate reductase (ferredoxin) activity", "definition": "Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin. [EC:1.5.7.1]"}
{"concept_id": "C2247204", "aliases": ["preQ0 oxidoreductase activity", "preQ0 reductase activity", "7-cyano-7-deazaguanine reductase activity", "YkvM", "QueF", "7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "preQ1 synthase activity", "definition": "Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH. [EC:1.7.1.13, RHEA:13409]"}
{"concept_id": "C2247205", "aliases": ["hydroxylamine:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydroxylamine oxidoreductase activity", "definition": "Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor. [EC:1.7.2.8]"}
{"concept_id": "C2247206", "aliases": ["AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity", "5'-adenylylsulfate reductase activity", "AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity"], "types": ["T044"], "canonical_name": "adenylyl-sulfate reductase (glutathione) activity", "definition": "Catalysis of the reaction: AMP + glutathione disulfide + H(+) + sulfite = 5'-adenylyl sulfate + 2 glutathione. [EC:1.8.4.9, RHEA:14141]"}
{"concept_id": "C2247207", "aliases": [], "types": ["T044"], "canonical_name": "plant-type 5'-adenylylsulfate reductase activity"}
{"concept_id": "C2247208", "aliases": [], "types": ["T044"], "canonical_name": "methionine sulfoxide reductase B activity"}
{"concept_id": "C2247209", "aliases": [], "types": ["T044"], "canonical_name": "selenoprotein R"}
{"concept_id": "C2247211", "aliases": ["free met-R-(o) reductase activity", "L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity", "FRMsr", "free-methionine (R)-S-oxide reductase activity"], "types": ["T044"], "canonical_name": "L-methionine-(R)-S-oxide reductase activity", "definition": "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin. [EC:1.8.4.14]"}
{"concept_id": "C2247212", "aliases": ["histone demethylase activity (H3-R2 specific)", "histone H3R2me demethylase activity"], "types": ["T044"], "canonical_name": "histone H3-methyl-arginine-2 demethylase activity", "definition": "Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:17947579, PMID:22483719, PMID:29233856]"}
{"concept_id": "C2247214", "aliases": ["hydrogen:acceptor oxidoreductase activity", "hydrogen:(acceptor) oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydrogenase (acceptor) activity", "definition": "Catalysis of the reaction: H2 + A = AH2. [EC:1.12.99.6]"}
{"concept_id": "C2247215", "aliases": [], "types": ["T044"], "canonical_name": "H2 producing hydrogenase activity"}
{"concept_id": "C2247216", "aliases": ["hydrogen-lyase activity", "hydrogenlyase activity"], "types": ["T044"], "canonical_name": "hydrogen-lyase activity"}
{"concept_id": "C2247217", "aliases": ["uptake hydrogenase activity"], "types": ["T044"], "canonical_name": "uptake hydrogenase activity"}
{"concept_id": "C2247218", "aliases": ["histone H3R3me demethylase activity", "histone demethylase activity (H4-R3 specific)"], "types": ["T044"], "canonical_name": "histone H3-methyl-arginine-3 demethylase activity", "definition": "Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:17947579]"}
{"concept_id": "C2247219", "aliases": ["ribosome localisation"], "types": ["T039"], "canonical_name": "ribosome localization", "definition": "A process in which a ribosome is transported to, and/or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C2247220", "aliases": ["linoleate diol synthase activity"], "types": ["T044"], "canonical_name": "linoleate diol synthase activity"}
{"concept_id": "C2247221", "aliases": ["acetylacetone dioxygenase activity", "Dke1", "acetylacetone:oxygen oxidoreductase activity", "diketone cleaving dioxygenase activity"], "types": ["T044"], "canonical_name": "acetylacetone-cleaving enzyme activity", "definition": "Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal. [EC:1.13.11.50]"}
{"concept_id": "C2247222", "aliases": [], "types": ["T044"], "canonical_name": "acetylacetone-cleaving enzyme"}
{"concept_id": "C2247223", "aliases": [], "types": ["T044"], "canonical_name": "diketone cleaving enzyme"}
{"concept_id": "C2247225", "aliases": [], "types": ["T044"], "canonical_name": "D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity"}
{"concept_id": "C2247226", "aliases": ["sulphur oxygenase reductase activity", "sulfur oxygenase/reductase activity", "sulphur oxygenase/reductase activity", "sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity", "SOR"], "types": ["T044"], "canonical_name": "sulfur oxygenase reductase activity", "definition": "Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+. [EC:1.13.11.55]"}
{"concept_id": "C2247228", "aliases": ["Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity", "Oplophorus luciferase activity"], "types": ["T044"], "canonical_name": "Oplophorus-luciferin 2-monooxygenase activity", "definition": "Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu. [EC:1.13.12.13]"}
{"concept_id": "C2247229", "aliases": ["glucoside 3-dehydrogenase activity", "D-aldohexoside:(acceptor) 3-oxidoreductase", "D-aldohexopyranoside dehydrogenase", "D-aldohexoside:cytochrome c oxidoreductase", "D-aldohexoside:acceptor 3-oxidoreductase"], "types": ["T044"], "definition": "Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor. [EC:1.1.99.13]", "canonical_name": "hexopyranoside-cytochrome c oxidoreductase"}
{"concept_id": "C2247230", "aliases": ["deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity", "clavaminic acid synthase activity"], "types": ["T044"], "canonical_name": "clavaminate synthase activity", "definition": "Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O. [EC:1.14.11.21]"}
{"concept_id": "C2247231", "aliases": [], "types": ["T044"], "canonical_name": "clavaminate synthase 2 activity"}
{"concept_id": "C2247232", "aliases": ["flavone synthase I activity", "FNS I", "flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity"], "types": ["T044"], "canonical_name": "flavone synthase activity", "definition": "Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O. [EC:1.14.20.5]"}
{"concept_id": "C2247233", "aliases": ["2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity", "IDS3"], "types": ["T044"], "canonical_name": "2'-deoxymugineic-acid 2'-dioxygenase activity", "definition": "Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O(2) = CO(2) + H(+) + mugineate + succinate. [EC:1.14.11.24, RHEA:12200]"}
{"concept_id": "C2247234", "aliases": ["mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity", "mugineic-acid 3-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2. [EC:1.14.11.25]", "canonical_name": "IDS2"}
{"concept_id": "C2247235", "aliases": ["response to glucagon stimulus"], "types": ["T043"], "canonical_name": "response to glucagon", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. [GOC:sl]"}
{"concept_id": "C2247236", "aliases": ["P-3-H", "L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity"], "types": ["T044"], "canonical_name": "proline 3-hydroxylase activity", "definition": "Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2. [EC:1.14.11.28]"}
{"concept_id": "C2247237", "aliases": [], "types": ["T044"], "canonical_name": "steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. [GOC:mah]"}
{"concept_id": "C2247238", "aliases": [], "types": ["T044"], "canonical_name": "steroid dehydrogenase activity, acting on the CH-CH group of donors", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative. [GOC:mah]"}
{"concept_id": "C2247239", "aliases": ["quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity", "2-oxo-1,2-dihydroquinoline 8-monooxygenase activity"], "types": ["T044"], "canonical_name": "2-hydroxyquinoline 8-monooxygenase activity", "definition": "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-2-ol = H(2)O + NAD(+) + quinoline-2,8-diol. [EC:1.14.13.61, RHEA:22080]"}
{"concept_id": "C2247240", "aliases": ["SUMO-targeted ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SUMO-targeted ubiquitin ligase complex", "definition": "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes. [GOC:vw, PMID:17762864, PMID:17762865]"}
{"concept_id": "C2247241", "aliases": ["2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity", "dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity"], "types": ["T044"], "canonical_name": "glyceollin synthase activity", "definition": "Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O. [EC:1.14.13.85]"}
{"concept_id": "C2247242", "aliases": ["apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming) activity", "2-HIS"], "types": ["T044"], "canonical_name": "2-hydroxyisoflavanone synthase activity", "definition": "Catalysis of the reaction: apigenin + 2 NADPH + 2 H+ + O2 = 2-hydroxy-2,3-dihydrogenistein + 2 NADP+ + H2O. [EC:1.14.13.86]"}
{"concept_id": "C2247243", "aliases": ["(2S)-flavanone 2-hydroxylase activity", "liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity"], "types": ["T044"], "canonical_name": "licodione synthase activity", "definition": "Catalysis of the reaction: H(+) + liquiritigenin + NADPH + O(2) = H(2)O + licodione + NADP(+). [EC:1.14.14.140, RHEA:15697]"}
{"concept_id": "C2247244", "aliases": ["F3'5'H", "flavanone,NADPH:oxygen oxidoreductase activity", "F3',5'H"], "types": ["T044"], "canonical_name": "flavonoid 3',5'-hydroxylase activity", "definition": "Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O. [EC:1.14.14.81]"}
{"concept_id": "C2247245", "aliases": [], "types": ["T044"], "canonical_name": "CYP Ge-3"}
{"concept_id": "C2247246", "aliases": [], "types": ["T044"], "canonical_name": "CYP81E1"}
{"concept_id": "C2247247", "aliases": ["isoflavone 2'-monooxygenase activity"], "types": ["T044"], "canonical_name": "isoflavone 2'-monooxygenase activity"}
{"concept_id": "C2247248", "aliases": [], "types": ["T026"], "canonical_name": "basal labyrinth", "definition": "A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane. [GOC:mah, GOC:sart, PMID:11640882]"}
{"concept_id": "C2247249", "aliases": ["DOSH", "10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity"], "types": ["T044"], "canonical_name": "deoxysarpagine hydroxylase activity", "definition": "Catalysis of the reaction: 10-deoxysarpagine + H(+) + NADPH + O(2) = H(2)O + NADP(+) + sarpagine. [EC:1.14.14.136, RHEA:14237]"}
{"concept_id": "C2247250", "aliases": ["PAMO", "phenylacetone,NADPH:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "phenylacetone monooxygenase activity", "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + phenylacetone = benzyl acetate + H(2)O + NADP(+). [EC:1.14.13.92, RHEA:10124]"}
{"concept_id": "C2247251", "aliases": ["lithocholate 6beta-monooxygenase activity", "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity", "cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity"], "types": ["T044"], "canonical_name": "lithocholate 6beta-hydroxylase activity", "definition": "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+). [EC:1.14.14.138, RHEA:18857]"}
{"concept_id": "C2247252", "aliases": [], "types": ["T044"], "canonical_name": "6beta-hydroxylase activity"}
{"concept_id": "C2247253", "aliases": [], "types": ["T044"], "canonical_name": "CYP3A10"}
{"concept_id": "C2247254", "aliases": ["sterol 12alpha-hydroxylase activity"], "types": ["T044"], "canonical_name": "sterol 12alpha-hydroxylase activity"}
{"concept_id": "C2247255", "aliases": ["5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity", "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity", "CYP8B1"], "types": ["T044"], "definition": "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H(+) + NADPH + O(2) = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(2)O + NADP(+). [EC:1.14.14.139, RHEA:15261]", "canonical_name": "5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity"}
{"concept_id": "C2247256", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 8B1"}
{"concept_id": "C2247257", "aliases": ["cholesterol 24S-hydroxylase activity", "CYP46", "cholesterol 24-monooxygenase activity", "cholesterol 24-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+). [EC:1.14.14.25, RHEA:22716]", "canonical_name": "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity"}
{"concept_id": "C2247258", "aliases": [], "types": ["T044"], "canonical_name": "CYP46A1"}
{"concept_id": "C2247259", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 46A1"}
{"concept_id": "C2247260", "aliases": ["24-hydroxycholesterol 7alpha-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [PMID:10748047, PMID:11013305, RHEA:46124]", "canonical_name": "24-hydroxycholesterol 7alpha-monooxygenase activity"}
{"concept_id": "C2247261", "aliases": ["25-hydroxycholesterol 7alpha-hydroxylase activity", "25-hydroxycholesterol 7alpha-monooxygenase activity", "CYP7B1", "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity"], "types": ["T044"], "definition": "Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O. [EC:1.14.14.29]", "canonical_name": "CYP7B1 oxysterol 7alpha-hydroxylase activity"}
{"concept_id": "C2247262", "aliases": ["senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity", "senecionine N-oxygenase activity", "senecionine monooxygenase (N-oxide-forming) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(+) + NADPH + O(2) + senecionine = H(2)O + NADP(+) + senecionine N-oxide. [EC:1.14.13.101, RHEA:11420]", "canonical_name": "SNO"}
{"concept_id": "C2247263", "aliases": ["D-alpha,beta-D-heptose 7-phosphate 1-kinase activity"], "types": ["T044"], "canonical_name": "heptose 7-phosphate kinase activity", "definition": "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP. [RHEA:27473]"}
{"concept_id": "C2247265", "aliases": ["cyanocobalamin reductase (NADPH; CN-eliminating) activity", "NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity", "NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity", "cob(I)alamin, cyanide:NADP+ oxidoreductase activity", "cyanocobalamin reductase (NADPH, cyanide-eliminating) activity", "cyanocobalamin reductase activity"], "types": ["T044"], "canonical_name": "cyanocobalamin reductase (cyanide-eliminating) activity", "definition": "Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP(+) = cyanocob(III)alamin + H(+) + NADPH. [RHEA:16113]"}
{"concept_id": "C2247266", "aliases": ["(2R,3S)-catechin:NADP+ 4-oxidoreductase activity", "leucocyanidin reductase activity"], "types": ["T044"], "canonical_name": "leucoanthocyanidin reductase activity", "definition": "Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+. [EC:1.17.1.3]"}
{"concept_id": "C2247267", "aliases": ["phenylacetyl-CoA:quinone oxidoreductase activity", "phenylacetyl-CoA:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "phenylacetyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 2 1,4-benzoquinone + H(2)O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA. [RHEA:15705]"}
{"concept_id": "C2247268", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethylfurfural reductase activity", "definition": "Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+. [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]"}
{"concept_id": "C2247269", "aliases": ["THCA-CoA oxidase activity", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity", "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity", "THC-CoA oxidase activity", "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity", "trihydroxycoprostanoyl-CoA oxidase activity"], "types": ["T044"], "canonical_name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity", "definition": "Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor. [EC:1.17.99.3]"}
{"concept_id": "C2247270", "aliases": ["bile acid 7-dehydroxylase activity", "cholate 7alpha-dehydroxylase activity", "7alpha-dehydroxylase activity"], "types": ["T044"], "canonical_name": "bile-acid 7alpha-dehydroxylase activity"}
{"concept_id": "C2247271", "aliases": ["2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "aureusidin synthase activity", "definition": "Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O. [EC:1.21.3.6]"}
{"concept_id": "C2247272", "aliases": ["acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity"], "types": ["T044"], "canonical_name": "sarcosine reductase activity", "definition": "Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin. [EC:1.21.4.3]"}
{"concept_id": "C2247273", "aliases": ["acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity"], "types": ["T044"], "canonical_name": "betaine reductase activity", "definition": "Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin. [EC:1.21.4.4]"}
{"concept_id": "C2247274", "aliases": ["(donor):sulfur oxidoreductase activity", "sulphur reductase activity"], "types": ["T044"], "canonical_name": "sulfur reductase activity", "definition": "Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide. [EC:1.12.98.4]"}
{"concept_id": "C2247275", "aliases": ["selenite:reduced acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "selenate reductase activity", "definition": "Catalysis of the reaction: 2 e(-) + 2 H(+) + selenate = H(2)O + selenite. [EC:1.97.1.9, RHEA:14029]"}
{"concept_id": "C2247276", "aliases": ["iodothyronine inner ring monodeiodinase activity", "acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity", "inner ring-deiodinating pathway", "iodothyronine 5-deiodinase activity"], "types": ["T044"], "canonical_name": "thyroxine 5-deiodinase activity", "definition": "Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2. [EC:1.21.99.3]"}
{"concept_id": "C2247278", "aliases": [], "types": ["T044"], "canonical_name": "type III iodothyronine deiodinase activity"}
{"concept_id": "C2247279", "aliases": ["S-adenosyl-L-methionine:myricetin O-methyltransferase activity"], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:myricetin O-methyltransferase activity"}
{"concept_id": "C2247280", "aliases": ["CrCOMT2"], "types": ["T044"], "canonical_name": "CrCOMT2"}
{"concept_id": "C2247281", "aliases": ["S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "isoflavone 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone. [EC:2.1.1.150]"}
{"concept_id": "C2247282", "aliases": ["S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "vitexin 2''-O-rhamnoside 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside. [EC:2.1.1.153]"}
{"concept_id": "C2247283", "aliases": ["CHMT", "isoliquiritigenin 2'-O-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H(+). [EC:2.1.1.154, RHEA:21608]", "canonical_name": "S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity"}
{"concept_id": "C2247284", "aliases": [], "types": ["T044"], "canonical_name": "chalcone OMT"}
{"concept_id": "C2247285", "aliases": ["S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity", "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity"], "types": ["T044"], "canonical_name": "kaempferol 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H(+) + kaempferide. [EC:2.1.1.155, RHEA:15105]"}
{"concept_id": "C2247286", "aliases": [], "types": ["T044"], "canonical_name": "F 4'-OMT"}
{"concept_id": "C2247289", "aliases": ["fluoroacetaldehyde:L-threonine aldehydetransferase activity"], "types": ["T044"], "canonical_name": "fluorothreonine transaldolase activity", "definition": "Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine. [RHEA:11748]"}
{"concept_id": "C2247290", "aliases": ["C18-CoA elongase activity", "acyl-CoA elongase activity", "stearoyl-CoA elongase activity", "stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity"], "types": ["T044"], "canonical_name": "icosanoyl-CoA synthase activity", "definition": "Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+. [EC:2.3.1.119]"}
{"concept_id": "C2247291", "aliases": ["malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity", "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity", "3MaT", "Dv3MaT"], "types": ["T044"], "canonical_name": "anthocyanin 6''-O-malonyltransferase activity", "definition": "Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside). [EC:2.3.1.171]"}
{"concept_id": "C2247292", "aliases": ["malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity"], "types": ["T044"], "canonical_name": "anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity", "definition": "Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin. [EC:2.3.1.172]"}
{"concept_id": "C2247293", "aliases": [], "types": ["T044"], "canonical_name": "Ss5MaT1"}
{"concept_id": "C2247294", "aliases": ["4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity"], "types": ["T044"], "canonical_name": "flavonol-3-O-triglucoside O-coumaroyltransferase activity", "definition": "Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]. [EC:2.3.1.173]"}
{"concept_id": "C2247295", "aliases": ["succinyl-CoA:acetyl-CoA C-succinyltransferase activity"], "types": ["T044"], "canonical_name": "3-oxoadipyl-CoA thiolase activity", "definition": "Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. [EC:2.3.1.174]"}
{"concept_id": "C2247296", "aliases": ["deacetylcephalosporin C acetyltransferase activity", "DAC acetyltransferase activity", "DAC-AT", "acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity", "acetyl-CoA:DAC acetyltransferase activity", "acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity", "acetyl coenzyme A:DAC acetyltransferase activity", "cefG", "CPC acetylhydrolase activity", "acetyl-CoA:DAC O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "deacetylcephalosporin-C acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA. [EC:2.3.1.175, RHEA:23860]"}
{"concept_id": "C2247297", "aliases": ["choloyl-CoA hydrolase activity", "PTE-2", "chenodeoxycholoyl-coenzyme A thioesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA. [EC:3.1.2.27]", "canonical_name": "choloyl-coenzyme A thioesterase activity"}
{"concept_id": "C2247298", "aliases": [], "types": ["T044"], "canonical_name": "peroxisomal thiolase 2 activity"}
{"concept_id": "C2247299", "aliases": [], "types": ["T044"], "canonical_name": "sterol carrier protein-chi"}
{"concept_id": "C2247300", "aliases": [], "types": ["T044"], "canonical_name": "sterol carrier protein-X"}
{"concept_id": "C2247301", "aliases": ["BIS", "biphenyl synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2. [EC:2.3.1.177]", "canonical_name": "malonyl-CoA:benzoyl-CoA malonyltransferase activity"}
{"concept_id": "C2247302", "aliases": ["acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity", "DABA acetyltransferase activity", "acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity", "DABAcT", "EctA", "DAB acetyltransferase activity", "L-2,4-diaminobutanoate acetyltransferase activity", "diaminobutyric acid acetyltransferase activity", "2,4-diaminobutanoate acetyltransferase activity", "L-2,4-diaminobutyrate acetyltransferase activity"], "types": ["T044"], "canonical_name": "diaminobutyrate acetyltransferase activity", "definition": "Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H(+). [EC:2.3.1.178, RHEA:16901]"}
{"concept_id": "C2247304", "aliases": ["acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity", "beta-ketoacyl-acyl carrier protein synthase III activity", "3-oxoacyl:ACP synthase III activity", "3-ketoacyl-acyl carrier protein synthase III activity", "KAS III", "KASIII", "beta-ketoacyl (acyl carrier protein) synthase III activity", "beta-ketoacyl-ACP synthase III activity", "FabH"], "types": ["T044"], "canonical_name": "beta-ketoacyl-acyl-carrier-protein synthase III activity", "definition": "Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2. [EC:2.3.1.180]"}
{"concept_id": "C2247305", "aliases": ["octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity", "octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity", "lipoyl (octanoyl)-acyl carrier protein:protein transferase activity", "lipoyl(octanoyl) transferase activity", "lipoate/octanoate transferase activity", "octanoyl-acyl carrier protein-protein N-octanoyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]. [RHEA:17665]", "canonical_name": "lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity"}
{"concept_id": "C2247306", "aliases": ["UDPglucose-DNA alpha-glucosyltransferase activity", "T6-HMC-alpha-glucosyl transferase activity", "uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity", "T2-HMC-alpha-glucosyl transferase activity", "UDP-glucose:DNA alpha-D-glucosyltransferase activity", "T4-HMC-alpha-glucosyl transferase activity"], "types": ["T044"], "canonical_name": "DNA alpha-glucosyltransferase activity", "definition": "Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA. [EC:2.4.1.26]"}
{"concept_id": "C2247307", "aliases": ["T4 phage beta-glucosyltransferase activity", "T4-HMC-beta-glucosyl transferase activity", "uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity", "T4-beta-glucosyl transferase activity", "UDP glucose-DNA beta-glucosyltransferase activity", "UDPglucose:DNA beta-D-glucosyltransferase activity", "UDP-glucose:DNA beta-D-glucosyltransferase activity"], "types": ["T045"], "canonical_name": "DNA beta-glucosyltransferase activity", "definition": "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA. [EC:2.4.1.27]"}
{"concept_id": "C2247308", "aliases": ["UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity", "T6-glucosyl-HMC-beta-glucosyl transferase activity", "T6-beta-glucosyl transferase activity", "UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity", "uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "glucosyl-DNA beta-glucosyltransferase activity", "definition": "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA. [EC:2.4.1.28]"}
{"concept_id": "C2247309", "aliases": ["UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity", "galactosylhydroxylysine-glucosyltransferase activity", "galactosylhydroxylysyl glucosyltransferase activity", "collagen glucosyltransferase activity", "UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity", "galactosylhydroxylysine glucosyltransferase activity", "collagen hydroxylysyl glucosyltransferase activity", "UDP-glucose-collagenglucosyltransferase activity", "uridine diphosphoglucose-collagen glucosyltransferase activity"], "types": ["T044"], "canonical_name": "procollagen glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen. [EC:2.4.1.66]"}
{"concept_id": "C2247310", "aliases": ["sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity", "sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "alternansucrase activity", "definition": "Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages. [EC:2.4.1.140]"}
{"concept_id": "C2247311", "aliases": [], "types": ["T044"], "canonical_name": "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity"}
{"concept_id": "C2247312", "aliases": ["amylase III activity", "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity", "1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "oligosaccharide 4-alpha-D-glucosyltransferase activity", "definition": "Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides. [EC:2.4.1.161]"}
{"concept_id": "C2247313", "aliases": ["uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity", "xyloglucan 4beta-D-glucosyltransferase activity", "UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity", "UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity", "xyloglucan glucosyltransferase activity"], "types": ["T044"], "canonical_name": "xyloglucan 4-glucosyltransferase activity", "definition": "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage. [EC:2.4.1.168]"}
{"concept_id": "C2247314", "aliases": ["UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity", "acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity", "uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity", "UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum. [EC:2.4.1.197]"}
{"concept_id": "C2247315", "aliases": ["ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity", "GG-phosphate synthase activity", "ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity", "GGPS", "glucosyl-glycerol-phosphate synthase activity"], "types": ["T044"], "canonical_name": "glucosylglycerol-phosphate synthase activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H(+). [EC:2.4.1.213, RHEA:12881]"}
{"concept_id": "C2247316", "aliases": ["O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity", "UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity"], "types": ["T044"], "canonical_name": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. [EC:2.4.1.222]"}
{"concept_id": "C2247317", "aliases": ["UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity", "Skp1-HyPro GlcNAc-transferase activity", "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity", "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity", "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity"], "types": ["T044"], "canonical_name": "Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline. [EC:2.4.1.229]"}
{"concept_id": "C2247318", "aliases": ["2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "kojibiose phosphorylase activity", "definition": "Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose. [EC:2.4.1.230, RHEA:11176]"}
{"concept_id": "C2247319", "aliases": ["alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "alpha,alpha-trehalose phosphorylase (configuration-retaining) activity", "definition": "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate. [EC:2.4.1.231]"}
{"concept_id": "C2247320", "aliases": [], "types": ["T044"], "canonical_name": "trehalose phosphorylase activity"}
{"concept_id": "C2247321", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethylfurfural reductase (NADH) activity", "definition": "Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+. [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]"}
{"concept_id": "C2247322", "aliases": ["UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity", "F3GalTase activity"], "types": ["T044"], "canonical_name": "kaempferol 3-O-galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside. [EC:2.4.1.234]"}
{"concept_id": "C2247323", "aliases": ["UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity", "1->2 UDP-rhamnosyltransferase activity", "UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity"], "types": ["T044"], "canonical_name": "flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]. [EC:2.4.1.236]"}
{"concept_id": "C2247324", "aliases": ["UDP-glucose:flavonol 7-O-glucosyltransferase activity", "UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "flavonol 7-O-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside. [EC:2.4.1.237]"}
{"concept_id": "C2247325", "aliases": ["UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity", "3'GT", "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "anthocyanin 3'-O-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside. [EC:2.4.1.238]"}
{"concept_id": "C2247326", "aliases": ["UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "flavonol-3-O-glucoside glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside. [EC:2.4.1.239]"}
{"concept_id": "C2247327", "aliases": ["UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "flavonol-3-O-glycoside glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside. [EC:2.4.1.240]"}
{"concept_id": "C2247328", "aliases": ["NDPglucose-starch glucosyltransferase activity", "granule-bound starch synthase I activity", "GBSS", "NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity", "granule-bound starch synthase II activity", "GBSSII", "starch synthase II activity", "starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity", "granule-bound starch synthase activity", "GBSSI"], "types": ["T044"], "definition": "Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1. [EC:2.4.1.242]", "canonical_name": "NDP-glucose-starch glucosyltransferase activity"}
{"concept_id": "C2247329", "aliases": [], "types": ["T044"], "canonical_name": "waxy protein"}
{"concept_id": "C2247330", "aliases": ["6G-fructotransferase activity", "fructan:fructan 6G-fructosyltransferase activity", "6G-FT", "1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity", "6G-FFT"], "types": ["T044"], "canonical_name": "6G-fructosyltransferase activity", "definition": "Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0). [EC:2.4.1.243]"}
{"concept_id": "C2247331", "aliases": ["beta1,4-N-acetylgalactosaminyltransferase IV activity", "beta1,4-N-acetylgalactosaminyltransferase activity", "beta1,4-N-acetylgalactosaminyltransferase III activity", "UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group. [EC:2.4.1.244]"}
{"concept_id": "C2247332", "aliases": [], "types": ["T044"], "canonical_name": "beta4GalNAc-T3"}
{"concept_id": "C2247333", "aliases": [], "types": ["T044"], "canonical_name": "beta4GalNAc-T4"}
{"concept_id": "C2247334", "aliases": ["xyloglucan 6-alpha-D-xylosyltransferase activity", "uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity", "UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity"], "types": ["T044"], "canonical_name": "xyloglucan 6-xylosyltransferase activity", "definition": "Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage. [EC:2.4.2.39]"}
{"concept_id": "C2247335", "aliases": ["galactose-6-sulfatase activity", "D-galactose-6-sulfate:alkyltransferase (cyclizing) activity", "galactose 6-sulfatase activity", "porphyran sulfatase activity"], "types": ["T044"], "canonical_name": "galactose-6-sulfurylase activity", "definition": "Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues. [EC:2.5.1.5]"}
{"concept_id": "C2247336", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethylfurfural reductase (NADPH) activity", "definition": "Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+. [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]"}
{"concept_id": "C2247337", "aliases": ["fluorinase activity", "S-adenosyl-L-methionine:fluoride adenosyltransferase activity"], "types": ["T044"], "canonical_name": "adenosyl-fluoride synthase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine. [EC:2.5.1.63]"}
{"concept_id": "C2247338", "aliases": ["O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity", "O-phosphoserine(thiol)-lyase activity"], "types": ["T044"], "canonical_name": "O-phosphoserine sulfhydrylase activity", "definition": "Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate. [EC:2.5.1.65]"}
{"concept_id": "C2247339", "aliases": ["N2-(2-carboxyethyl)arginine synthase activity", "N2-(2-carboxyethyl)arginine synthetase activity", "glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity", "CEA synthetase activity", "CEAS"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H(+) + phosphate. [EC:2.5.1.66, RHEA:10556]", "canonical_name": "glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity"}
{"concept_id": "C2247340", "aliases": ["dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity", "CPPase activity"], "types": ["T044"], "canonical_name": "chrysanthemyl diphosphate synthase activity", "definition": "Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate. [EC:2.5.1.67, RHEA:14009]"}
{"concept_id": "C2247341", "aliases": ["(Z)-farnesyl diphosphate synthase activity", "geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity"], "types": ["T044"], "canonical_name": "Z-farnesyl diphosphate synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate. [EC:2.5.1.68, RHEA:23300]"}
{"concept_id": "C2247342", "aliases": ["FDS-5", "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity"], "types": ["T044"], "canonical_name": "lavandulyl diphosphate synthase activity", "definition": "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate. [EC:2.5.1.69, RHEA:21676]"}
{"concept_id": "C2247343", "aliases": ["3,5-dinitrotyrosine aminotransferase activity", "thyroid-hormone aminotransferase activity", "3,5-dinitrotyrosine transaminase activity", "thyroid hormone aminotransferase activity", "L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "thyroid-hormone transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate. [EC:2.6.1.26, RHEA:19133]"}
{"concept_id": "C2247344", "aliases": ["prephenate aspartate aminotransferase activity", "L-aspartate:prephenate aminotransferase activity", "PAT", "L-arogenate:oxaloacetate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate. [EC:2.6.1.78]", "canonical_name": "aspartate-prephenate aminotransferase activity"}
{"concept_id": "C2247345", "aliases": ["prephenate transaminase activity"], "types": ["T044"], "canonical_name": "prephenate transaminase activity"}
{"concept_id": "C2247346", "aliases": ["PAT", "L-arogenate:2-oxoglutarate aminotransferase activity", "L-glutamate:prephenate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate. [EC:2.6.1.79, RHEA:22880]", "canonical_name": "glutamate-prephenate aminotransferase activity"}
{"concept_id": "C2247347", "aliases": ["nicotianamine:2-oxoglutarate aminotransferase activity", "NAAT", "NAAT-I", "nicotianamine transaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate. [EC:2.6.1.80, RHEA:22104]", "canonical_name": "nicotianamine aminotransferase activity"}
{"concept_id": "C2247348", "aliases": [], "types": ["T044"], "canonical_name": "NAAT-II"}
{"concept_id": "C2247349", "aliases": [], "types": ["T044"], "canonical_name": "NAAT-III"}
{"concept_id": "C2247350", "aliases": ["1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity", "PNP synthase activity", "pyridoxine 5-phosphate phospho lyase activity"], "types": ["T044"], "canonical_name": "pyridoxine 5'-phosphate synthase activity", "definition": "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H(2)O + H(+) + phosphate + pyridoxine 5'-phosphate. [RHEA:15265]"}
{"concept_id": "C2247351", "aliases": [], "types": ["T044"], "canonical_name": "PPIP5K1"}
{"concept_id": "C2247352", "aliases": [], "types": ["T044"], "canonical_name": "PPIP5K2"}
{"concept_id": "C2247353", "aliases": [], "types": ["T044"], "canonical_name": "furaldehyde metabolic process", "definition": "The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass. [GOC:jp, PMID:15338422, PMID:16652391]"}
{"concept_id": "C2247354", "aliases": [], "types": ["T044"], "canonical_name": "regulation of NAD(P)H oxidase activity", "definition": "Any process that modulates the activity of the enzyme NAD(P)H oxidase. [GOC:mah]"}
{"concept_id": "C2247355", "aliases": ["down-regulation of NAD(P)H oxidase activity", "downregulation of NAD(P)H oxidase activity", "down regulation of NAD(P)H oxidase activity"], "types": ["T040"], "canonical_name": "negative regulation of NAD(P)H oxidase activity", "definition": "Any process that stops or reduces the activity of the enzyme NAD(P)H oxidase. [GOC:mah]"}
{"concept_id": "C2247356", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of NAD(P)H oxidase activity"}
{"concept_id": "C2247357", "aliases": ["UMPK", "SmbA", "PyrH", "UMP kinase activity", "uridine monophosphate kinase activity", "ATP:UMP phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + UMP = ADP + UDP. [EC:2.7.4.22]", "canonical_name": "UMP-kinase activity"}
{"concept_id": "C2247358", "aliases": ["PhnN", "ATP:ribose-1,5-bisphosphate phosphotransferase activity", "ribose 1,5-bisphosphokinase activity"], "types": ["T044"], "canonical_name": "ribose 1,5-bisphosphate phosphokinase activity", "definition": "Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H(+). [EC:2.7.4.23, RHEA:20109]"}
{"concept_id": "C2247359", "aliases": ["up-regulation of NAD(P)H oxidase activity", "up regulation of NAD(P)H oxidase activity", "upregulation of NAD(P)H oxidase activity"], "types": ["T040"], "canonical_name": "positive regulation of NAD(P)H oxidase activity", "definition": "Any process that activates or increases the activity of the enzyme NAD(P)H oxidase. [GOC:mah]"}
{"concept_id": "C2247360", "aliases": [], "types": ["T040"], "canonical_name": "activation of NAD(P)H oxidase activity"}
{"concept_id": "C2247361", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of NAD(P)H oxidase activity"}
{"concept_id": "C2247362", "aliases": ["nucleoside bisphosphate metabolism"], "types": ["T044"], "canonical_name": "nucleoside bisphosphate metabolic process", "definition": "The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247363", "aliases": ["nucleoside bisphosphate biosynthesis", "nucleoside bisphosphate anabolism", "nucleoside bisphosphatehate synthesis", "nucleoside bisphosphate formation"], "types": ["T044"], "canonical_name": "nucleoside bisphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247365", "aliases": ["nucleoside bisphosphate catabolism", "nucleoside bisphosphate degradation", "nucleoside bisphosphate breakdown"], "types": ["T045"], "canonical_name": "nucleoside bisphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247366", "aliases": ["3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity", "adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity"], "types": ["T044"], "canonical_name": "thiol sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate. [EC:2.8.2.16]"}
{"concept_id": "C2247368", "aliases": ["heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity", "glucosaminyl 3-O-sulfotransferase 2 activity"], "types": ["T044"], "canonical_name": "[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity", "definition": "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S. [EC:2.8.2.29]"}
{"concept_id": "C2247369", "aliases": ["3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity"], "types": ["T044"], "canonical_name": "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity"}
{"concept_id": "C2247370", "aliases": [], "types": ["T044"], "canonical_name": "3-OST-2"}
{"concept_id": "C2247372", "aliases": ["glucosaminyl 3-O-sulfotransferase activity", "3-OST-1 activity", "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity", "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity"], "types": ["T044"], "canonical_name": "[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity", "definition": "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. [EC:2.8.2.23]"}
{"concept_id": "C2247373", "aliases": [], "types": ["T044"], "canonical_name": "isoform/isozyme 2 (3-OST-2, HS3ST2)"}
{"concept_id": "C2247374", "aliases": ["glucosaminyl 3-O-sulfotransferase 3 activity", "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity", "glucosaminyl 3-O-sulfotransferase 3a, 3b activity", "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity"], "types": ["T044"], "canonical_name": "[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity", "definition": "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. [EC:2.8.2.30]"}
{"concept_id": "C2247375", "aliases": [], "types": ["T044"], "canonical_name": "3-OST-3"}
{"concept_id": "C2247376", "aliases": [], "types": ["T044"], "canonical_name": "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)"}
{"concept_id": "C2247377", "aliases": ["3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity"], "types": ["T044"], "canonical_name": "petromyzonol sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H(+). [EC:2.8.2.31, RHEA:16997]"}
{"concept_id": "C2247378", "aliases": [], "types": ["T044"], "canonical_name": "PZ-SULT"}
{"concept_id": "C2247379", "aliases": [], "types": ["T044"], "canonical_name": "scymnol sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H(+). [EC:2.8.2.32, RHEA:15477]"}
{"concept_id": "C2247380", "aliases": ["ribonucleoside bisphosphate metabolism"], "types": ["T045"], "canonical_name": "ribonucleoside bisphosphate metabolic process", "definition": "The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247381", "aliases": ["BAST", "3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity", "bile acid:PAPS:sulfotransferase activity"], "types": ["T044"], "canonical_name": "glycochenodeoxycholate sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H(+). [EC:2.8.2.34, RHEA:17689]"}
{"concept_id": "C2247383", "aliases": ["succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity", "succinyl-CoA:benzylsuccinate CoA-transferase activity", "benzylsuccinate CoA-transferase activity"], "types": ["T044"], "canonical_name": "succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity", "definition": "Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate. [EC:2.8.3.15, RHEA:16469]"}
{"concept_id": "C2247384", "aliases": ["acetylajmaline esterase activity", "AAE", "acetylajmalan esterase activity", "2beta(R)-17-O-acetylajmalan:acetylesterase activity"], "types": ["T044"], "definition": "Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate. [EC:3.1.1.80]", "canonical_name": "17-O-acetylajmaline O-acetylhydrolase activity"}
{"concept_id": "C2247385", "aliases": ["phenylglyoxylyl-CoA hydrolase activity"], "types": ["T044"], "canonical_name": "phenylacetyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: H(2)O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate. [EC:3.1.2.25, RHEA:15337]"}
{"concept_id": "C2247386", "aliases": [], "types": ["T044"], "canonical_name": "bile-acid-CoA hydrolase activity"}
{"concept_id": "C2247387", "aliases": [], "types": ["T044"], "canonical_name": "peroxisomal acyl-CoA thioesterase 2 activity"}
{"concept_id": "C2247388", "aliases": ["vitamin B6 (pyridoxine) phosphatase activity", "PNP phosphatase activity", "PLP phosphatase activity", "vitamin B6-phosphate phosphatase activity", "pyridoxal-5'-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "pyridoxal phosphatase activity", "definition": "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate. [EC:3.1.3.74]"}
{"concept_id": "C2247389", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate, and phosphocholine + H2O = choline + phosphate. [EC:3.1.3.75]", "canonical_name": "PHOSPHO1"}
{"concept_id": "C2247391", "aliases": ["cellulose-sulfate sulfohydrolase activity"], "types": ["T044"], "canonical_name": "cellulose-polysulfatase activity", "definition": "Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin. [EC:3.1.6.7]"}
{"concept_id": "C2247392", "aliases": ["4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity"], "types": ["T044"], "canonical_name": "chondro-4-sulfatase activity", "definition": "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate. [EC:3.1.6.9, RHEA:11444]"}
{"concept_id": "C2247393", "aliases": ["4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity"], "types": ["T044"], "canonical_name": "chondro-6-sulfatase activity", "definition": "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate. [EC:3.1.6.10, RHEA:10536]"}
{"concept_id": "C2247394", "aliases": ["N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity"], "types": ["T044"], "canonical_name": "N-sulfoglucosamine-3-sulfatase activity", "definition": "Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin. [EC:3.1.6.15]"}
{"concept_id": "C2247395", "aliases": ["RNase D activity"], "types": ["T045"], "canonical_name": "ribonuclease D activity", "definition": "Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides. [EC:3.1.13.5]"}
{"concept_id": "C2247396", "aliases": ["Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity", "Streptomyces glaucescens exocytoplasmic endonuclease activity", "5'-CC-3'-preferring endodeoxyribonuclease activity", "Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity"], "types": ["T045"], "canonical_name": "CC-preferring endodeoxyribonuclease activity", "definition": "Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC. [EC:3.1.21.6]"}
{"concept_id": "C2247397", "aliases": ["T4 endonuclease V activity", "bacteriophage T4 endodeoxyribonuclease V activity", "endodeoxyribonuclease (pyrimidine dimer) activity"], "types": ["T045"], "canonical_name": "deoxyribonuclease (pyrimidine dimer) activity", "definition": "Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate. [EC:3.1.25.1]"}
{"concept_id": "C2247398", "aliases": ["endoribonuclease IV activity"], "types": ["T045"], "canonical_name": "ribonuclease IV activity", "definition": "Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups. [EC:3.1.26.6]"}
{"concept_id": "C2247399", "aliases": [], "types": ["T045"], "canonical_name": "ribonuclease P4 activity", "definition": "Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor. [EC:3.1.26.7]"}
{"concept_id": "C2247400", "aliases": ["ribonuclease (uracil-specific) activity", "uracil-specific RNase activity", "uracil-specific endoribonuclease activity"], "types": ["T045"], "canonical_name": "ribonuclease [poly-(U)-specific] activity", "definition": "Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups. [EC:3.1.26.9]"}
{"concept_id": "C2247401", "aliases": ["poly(U)- and poly(C)-specific endoribonuclease activity"], "types": ["T045"], "canonical_name": "ribonuclease IX activity", "definition": "Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups. [EC:3.1.26.10]"}
{"concept_id": "C2247402", "aliases": ["RNase M activity", "ribonuclease U4 activity", "nonbase-specific RNase activity", "ribonucleate 3'-oligonucleotide hydrolase activity", "non-base specific ribonuclease activity", "RNase T2 activity", "ribonuclease (non-base specific) activity", "RNAase CL activity", "ribonuclease M activity", "Escherichia coli ribonuclease II activity", "RNase Ms activity", "ribonuclease PP3 activity", "ribonuclease N2 activity", "Escherichia coli ribonuclease I' ribonuclease PP2 activity", "RNase (non-base specific) activity", "nonspecific RNase activity", "acid RNase activity", "ribonnuclease (non-base specific) activity", "acid ribonuclease activity", "base-non-specific ribonuclease activity"], "types": ["T045"], "canonical_name": "ribonuclease T2 activity", "definition": "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. [EC:4.6.1.19]"}
{"concept_id": "C2247404", "aliases": ["ribonucleate nucleotido-2'-transferase (cyclizing) activity"], "types": ["T045"], "canonical_name": "ribonucleate nucleotido-2'-transferase (cyclizing) activity"}
{"concept_id": "C2247406", "aliases": ["proteus mirabilis RNase activity"], "types": ["T045"], "canonical_name": "Bacillus subtilis ribonuclease activity", "definition": "Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides. [EC:4.6.1.22]"}
{"concept_id": "C2247407", "aliases": ["purine-specific ribonuclease activity", "ribonuclease (purine) activity", "trichoderma koningi RNase III activity", "purine specific endoribonuclease activity", "purine-specific RNase activity", "pleospora RNase activity", "RNase U2 activity"], "types": ["T045"], "canonical_name": "ribonuclease U2 activity", "definition": "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates. [EC:4.6.1.20]"}
{"concept_id": "C2247408", "aliases": ["ribonuclease F (E. coli) activity", "RNase F activity"], "types": ["T045"], "canonical_name": "ribonuclease F activity", "definition": "Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups. [EC:3.1.27.7]"}
{"concept_id": "C2247409", "aliases": ["endoribonuclease V activity"], "types": ["T045"], "canonical_name": "ribonuclease V activity", "definition": "Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP. [EC:3.1.27.8]"}
{"concept_id": "C2247410", "aliases": [], "types": ["T045"], "canonical_name": "rRNA endonuclease activity", "definition": "Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes. [GOC:curators]"}
{"concept_id": "C2247411", "aliases": [], "types": ["T045"], "canonical_name": "alpha-sarcin"}
{"concept_id": "C2247415", "aliases": ["1,6-alpha-D-glucan 6-glucanohydrolase activity", "alpha-1,6-glucan-6-glucanohydrolase activity", "DL 2", "dextran hydrolase activity", "endo-dextranase activity", "endodextranase activity", "alpha-D-1,6-glucan-6-glucanohydrolase activity"], "types": ["T044"], "canonical_name": "dextranase activity", "definition": "Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran. [EC:3.2.1.11]"}
{"concept_id": "C2247416", "aliases": [], "types": ["T044"], "canonical_name": "dextranase DL 2 activity"}
{"concept_id": "C2247417", "aliases": ["1,3-xylanase activity", "endo-1,3-xylanase activity", "1,3-beta-D-xylan xylanohydrolase activity", "1,3-beta-xylanase activity", "endo-beta-1,3-xylanase activity", "beta-1,3-xylanase activity", "endo-1,3-beta-xylanase activity"], "types": ["T044"], "canonical_name": "xylan endo-1,3-beta-xylosidase activity", "definition": "Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans. [EC:3.2.1.32]"}
{"concept_id": "C2247418", "aliases": ["hyaluronate 3-glycanohydrolase activity", "orgelase activity", "glucuronoglucosaminoglycan hyaluronate lyase activity"], "types": ["T044"], "canonical_name": "hyaluronoglucuronidase activity", "definition": "Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate. [EC:3.2.1.36]"}
{"concept_id": "C2247419", "aliases": ["beta-D-fucoside fucohydrolase activity", "beta-fucosidase activity"], "types": ["T044"], "canonical_name": "beta-D-fucosidase activity", "definition": "Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides. [EC:3.2.1.38]"}
{"concept_id": "C2247420", "aliases": ["beta-L-rhamnoside rhamnohydrolase activity"], "types": ["T044"], "canonical_name": "beta-L-rhamnosidase activity", "definition": "Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides. [EC:3.2.1.43]"}
{"concept_id": "C2247421", "aliases": ["poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity"], "types": ["T044"], "canonical_name": "fucoidanase activity", "definition": "Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate. [PMID:11910806, PMID:6417453]"}
{"concept_id": "C2247422", "aliases": ["G4-amylase activity", "1,4-alpha-D-glucan maltotetraohydrolase activity", "exo-maltotetraohydrolase activity", "glucan 1,4-alpha-maltotetrahydrolase activity", "maltotetraose-forming amylase activity"], "types": ["T044"], "canonical_name": "glucan 1,4-alpha-maltotetraohydrolase activity", "definition": "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends. [EC:3.2.1.60]"}
{"concept_id": "C2247423", "aliases": ["1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity"], "types": ["T044"], "canonical_name": "mycodextranase activity", "definition": "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds. [EC:3.2.1.61]"}
{"concept_id": "C2247424", "aliases": ["2,6-beta-D-fructan 6-levanbiohydrolase activity", "2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity", "2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity", "levanbiose-producing levanase activity", "beta-2,6-fructan-6-levanbiohydrolase activity"], "types": ["T044"], "canonical_name": "2,6-beta-fructan 6-levanbiohydrolase activity", "definition": "Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain. [EC:3.2.1.64]"}
{"concept_id": "C2247425", "aliases": ["endo-(1->2)-beta-D-glucanase activity", "endo-1,2-beta-glucanase activity", "beta-D-1,2-glucanase activity", "1,2-beta-D-glucan glucanohydrolase activity"], "types": ["T044"], "canonical_name": "glucan endo-1,2-beta-glucosidase activity", "definition": "Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans. [EC:3.2.1.71]"}
{"concept_id": "C2247426", "aliases": ["exo-beta-1,3'-xylanase activity", "beta-1,3'-xylanase activity", "1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity", "1,3-beta-D-xylan xylohydrolase activity", "exo-1,3-beta-xylosidase activity"], "types": ["T044"], "canonical_name": "xylan 1,3-beta-xylosidase activity", "definition": "Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans. [EC:3.2.1.72]"}
{"concept_id": "C2247427", "aliases": ["1,2-1,3-alpha-D-mannan mannohydrolase activity", "exo-1,2-1,3-alpha-mannosidase activity"], "types": ["T044"], "canonical_name": "mannan 1,2-(1,3)-alpha-mannosidase activity", "definition": "Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose. [EC:3.2.1.77]"}
{"concept_id": "C2247428", "aliases": ["agarose 4-glycanohydrolase activity", "AgaB", "AgaA"], "types": ["T044"], "canonical_name": "beta-agarase activity", "definition": "Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product. [EC:3.2.1.81]"}
{"concept_id": "C2247429", "aliases": ["agarase activity"], "types": ["T044"], "canonical_name": "agarase activity"}
{"concept_id": "C2247430", "aliases": ["agarose 3-glycanohydrolase activity"], "types": ["T044"], "canonical_name": "agarose 3-glycanohydrolase activity"}
{"concept_id": "C2247431", "aliases": ["exopolygalacturanosidase activity", "exopolygalacturonosidase activity"], "types": ["T044"], "canonical_name": "exo-poly-alpha-galacturonosidase activity", "definition": "Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate. [EC:3.2.1.82]"}
{"concept_id": "C2247432", "aliases": ["kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity", "kappa-carrageenan 4-beta-D-glycanohydrolase activity"], "types": ["T044"], "canonical_name": "kappa-carrageenase activity", "definition": "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans. [EC:3.2.1.83]"}
{"concept_id": "C2247433", "aliases": ["exo-1,3-alpha-glucanase activity", "1,3-alpha-D-glucan 3-glucohydrolase activity"], "types": ["T044"], "canonical_name": "glucan 1,3-alpha-glucosidase activity", "definition": "Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans. [EC:3.2.1.84]"}
{"concept_id": "C2247434", "aliases": ["6-phospho-beta-D-galactosidase activity", "beta-D-phosphogalactoside galactohydrolase activity", "6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity", "phospho-beta-D-galactosidase activity", "phospho-beta-galactosidase activity"], "types": ["T044"], "canonical_name": "6-phospho-beta-galactosidase activity", "definition": "Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. [EC:3.2.1.85]"}
{"concept_id": "C2247435", "aliases": ["polysaccharide depolymerase activity", "aerobacter-capsular-polysaccharide galactohydrolase activity", "capsular polysaccharide galactohydrolase activity"], "types": ["T044"], "canonical_name": "capsular-polysaccharide endo-1,3-alpha-galactosidase activity", "definition": "Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide. [EC:3.2.1.87]"}
{"concept_id": "C2247436", "aliases": ["beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity", "peptidoglycan beta-N-acetylmuramoylexohydrolase activity", "exo-beta-N-acetylmuramidase activity", "exo-beta-acetylmuramidase activity"], "types": ["T044"], "canonical_name": "peptidoglycan beta-N-acetylmuramidase activity", "definition": "Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues. [EC:3.2.1.92]"}
{"concept_id": "C2247437", "aliases": ["isomaltodextranase activity", "exo-isomaltohydrolase activity", "1,6-alpha-D-glucan isomaltohydrolase activity", "isomalto-dextranase activity", "G2-dextranase activity"], "types": ["T044"], "canonical_name": "glucan 1,6-alpha-isomaltosidase activity", "definition": "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains. [EC:3.2.1.94]"}
{"concept_id": "C2247438", "aliases": ["exo-isomaltotriohydrolase activity", "1,6-alpha-D-glucan isomaltotriohydrolase activity"], "types": ["T044"], "canonical_name": "dextran 1,6-alpha-isomaltotriosidase activity", "definition": "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains. [EC:3.2.1.95]"}
{"concept_id": "C2247439", "aliases": ["endo-beta-N-acetylglucosaminidase L activity", "endo-beta-N-acetylglucosaminidase activity", "endo-beta-N-acetylglucosaminidase F activity", "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity", "endo-N-acetyl-beta-D-glucosaminidase activity", "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity", "endoglycosidase S activity", "endo-beta-N-acetylglucosaminidase H activity", "endo-N-acetyl-beta-glucosaminidase activity", "endo-beta-(1->4)-N-acetylglucosaminidase activity", "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity", "endo-beta-acetylglucosaminidase activity", "endoglycosidase H activity", "endo-beta-N-acetylglucosaminidase D activity", "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity", "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity", "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity"], "types": ["T044"], "canonical_name": "mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity", "definition": "Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. [EC:3.2.1.96]"}
{"concept_id": "C2247440", "aliases": ["D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity"], "types": ["T044"], "canonical_name": "glycopeptide alpha-N-acetylgalactosaminidase activity", "definition": "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine in mucin-type glycoproteins. [EC:3.2.1.97, MetaCyc:3.2.1.97-RXN]"}
{"concept_id": "C2247441", "aliases": [], "types": ["T044"], "canonical_name": "endo-alpha-N-acetylgalactosaminidase activity"}
{"concept_id": "C2247442", "aliases": ["exo-maltohexaohydrolase activity", "G6-amylase activity", "1,4-alpha-D-glucan maltohexaohydrolase activity", "maltohexaose-producing amylase activity"], "types": ["T044"], "canonical_name": "glucan 1,4-alpha-maltohexaosidase activity", "definition": "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends. [EC:3.2.1.98]"}
{"concept_id": "C2247443", "aliases": ["exo-beta-mannanase activity", "mannan 1,4-beta-mannobiosidase activity", "exo-1,4-beta-mannobiohydrolase activity"], "types": ["T044"], "canonical_name": "mannan 1,4-mannobiosidase activity", "definition": "Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends. [EC:3.2.1.100]"}
{"concept_id": "C2247444", "aliases": [], "types": ["T044"], "canonical_name": "1,4-beta-D-mannan mannobiohydrolase activity"}
{"concept_id": "C2247445", "aliases": ["blood-group-substance 1,4-beta-D-galactanohydrolase activity"], "types": ["T044"], "canonical_name": "blood-group-substance endo-1,4-beta-galactosidase activity", "definition": "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances. [EC:3.2.1.102]"}
{"concept_id": "C2247446", "aliases": ["endo-beta-galactosidase activity"], "types": ["T044"], "canonical_name": "endo-beta-galactosidase activity"}
{"concept_id": "C2247447", "aliases": ["keratan sulfate endogalactosidase activity", "keratan-sulfate 1,4-beta-D-galactanohydrolase activity", "keratanase activity"], "types": ["T044"], "canonical_name": "keratan-sulfate endo-1,4-beta-galactosidase activity", "definition": "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate. [EC:3.2.1.103]"}
{"concept_id": "C2247448", "aliases": ["galactosaminoglycan glycanohydrolase activity"], "types": ["T044"], "canonical_name": "endogalactosaminidase activity", "definition": "Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine). [EC:3.2.1.109]"}
{"concept_id": "C2247449", "aliases": ["almond emulsin fucosidase I activity", "3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity"], "types": ["T044"], "canonical_name": "1,3-alpha-L-fucosidase activity", "definition": "Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins. [EC:3.2.1.111]"}
{"concept_id": "C2247450", "aliases": ["1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity", "dextran alpha-1,2 debranching enzyme", "dextran 1,2-alpha-glucosidase activity"], "types": ["T044"], "canonical_name": "branched-dextran exo-1,2-alpha-glucosidase activity", "definition": "Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose. [EC:3.2.1.115]"}
{"concept_id": "C2247451", "aliases": ["1,4-alpha-D-glucan maltotriohydrolase activity", "exo-maltotriohydrolase activity", "maltotriohydrolase activity"], "types": ["T044"], "canonical_name": "glucan 1,4-alpha-maltotriohydrolase activity", "definition": "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends. [EC:3.2.1.116]"}
{"concept_id": "C2247452", "aliases": ["oligoxyloglucan xyloglucohydrolase activity", "isoprimeverose-producing oligoxyloglucan hydrolase activity", "oligoxyloglucan hydrolase activity"], "types": ["T044"], "canonical_name": "oligoxyloglucan beta-glycosidase activity", "definition": "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends. [EC:3.2.1.120]"}
{"concept_id": "C2247453", "aliases": ["polymannuronic acid polymerase activity", "poly(mannuronide) mannuronohydrolase activity"], "types": ["T044"], "canonical_name": "polymannuronate hydrolase activity", "definition": "Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate. [EC:3.2.1.121]"}
{"concept_id": "C2247454", "aliases": ["octulofuranosylono hydrolase activity", "octulopyranosylonohydrolase activity", "octulosylono hydrolase activity", "capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity", "2-keto-3-deoxyoctonate hydrolase activity"], "types": ["T044"], "canonical_name": "3-deoxy-2-octulosonidase activity", "definition": "Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides. [EC:3.2.1.124]"}
{"concept_id": "C2247455", "aliases": ["1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity"], "types": ["T044"], "canonical_name": "1,6-alpha-L-fucosidase activity", "definition": "Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin. [EC:3.2.1.127]"}
{"concept_id": "C2247456", "aliases": ["alpha-(1->2)-glucuronidase activity", "xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity", "1,2-alpha-glucuronidase activity"], "types": ["T044"], "canonical_name": "xylan alpha-1,2-glucuronosidase activity", "definition": "Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans. [EC:3.2.1.131]"}
{"concept_id": "C2247457", "aliases": ["endoarabinoxylanase activity", "glucuronoxylanase activity", "feraxanase activity", "glucuronoxylan xylohydrolase activity", "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity", "glucuronoxylan xylanohydrolase activity", "feraxan endoxylanase activity"], "types": ["T044"], "canonical_name": "glucuronoarabinoxylan endo-1,4-beta-xylanase activity", "definition": "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans. [EC:3.2.1.136]"}
{"concept_id": "C2247458", "aliases": ["1,2-1,6-alpha-D-mannan D-mannohydrolase activity", "exo-1,2-1,6-alpha-mannosidase activity"], "types": ["T044"], "canonical_name": "mannan exo-1,2-1,6-alpha-mannosidase activity", "definition": "Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose. [EC:3.2.1.137]"}
{"concept_id": "C2247459", "aliases": ["maltooligosyl trehalose trehalohydrolase activity", "4-alpha-D-{(1,4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity", "malto-oligosyltrehalose trehalohydrolase activity", "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity"], "types": ["T044"], "canonical_name": "4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity", "definition": "Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan. [EC:3.2.1.141]"}
{"concept_id": "C2247460", "aliases": ["galactan (1,3)-beta-D-galactosidase activity", "galactan (1->3)-beta-D-galactosidase activity"], "types": ["T044"], "canonical_name": "galactan 1,3-beta-galactosidase activity", "definition": "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans. [EC:3.2.1.145]"}
{"concept_id": "C2247461", "aliases": ["beta-D-galactofuranoside hydrolase activity", "beta-D-galactofuranosidase activity", "exo-beta-galactofuranosidase activity", "exo-beta-D-galactofuranosidase activity"], "types": ["T044"], "canonical_name": "beta-galactofuranosidase activity", "definition": "Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose. [EC:3.2.1.146]"}
{"concept_id": "C2247462", "aliases": ["oligoxyloglucan reducing end-specific cellobiohydrolase activity", "oligoxyloglucan reducing-end cellobiohydrolase activity"], "types": ["T044"], "canonical_name": "oligoxyloglucan reducing-end-specific cellobiohydrolase activity", "definition": "Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted. [EC:3.2.1.150]"}
{"concept_id": "C2247463", "aliases": ["XEG", "xyloglucanendohydrolase activity", "XH", "xyloglucan-specific endo-beta-1,4-glucanase activity", "xyloglucan endo-beta-1,4-glucanase activity", "[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan. [EC:3.2.1.151]", "canonical_name": "xyloglucanase activity"}
{"concept_id": "C2247464", "aliases": ["endo-beta-mannosidase activity"], "types": ["T044"], "canonical_name": "mannosylglycoprotein endo-beta-mannosidase activity", "definition": "Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences. [EC:3.2.1.152]"}
{"concept_id": "C2247465", "aliases": ["beta-(2,1)-linkage-specific fructan-beta-fructosidase activity", "beta-(2,1)-D-fructan fructohydrolase activity", "1-fructan exohydrolase activity", "beta-(2,1)-fructan exohydrolase activity"], "types": ["T044"], "canonical_name": "fructan beta-(2,1)-fructosidase activity", "definition": "Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans. [EC:3.2.1.153]"}
{"concept_id": "C2247466", "aliases": [], "types": ["T044"], "canonical_name": "1-FEH II"}
{"concept_id": "C2247467", "aliases": [], "types": ["T044"], "canonical_name": "1-FEH w1"}
{"concept_id": "C2247468", "aliases": [], "types": ["T044"], "canonical_name": "1-FEH w2"}
{"concept_id": "C2247469", "aliases": ["beta-(2,6)-D-fructan fructohydrolase activity", "6-FEH", "beta-(2,6)-fructan exohydrolase activity"], "types": ["T044"], "canonical_name": "fructan beta-(2,6)-fructosidase activity", "definition": "Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans. [EC:3.2.1.154]"}
{"concept_id": "C2247470", "aliases": ["[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity", "Cel74A"], "types": ["T044"], "canonical_name": "xyloglucan-specific exo-beta-1,4-glucanase activity", "definition": "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan. [EC:3.2.1.155]"}
{"concept_id": "C2247471", "aliases": ["oligosaccharide reducing-end xylanase activity", "reducing end xylose-releasing exo-oligoxylanase activity", "Rex"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides. [EC:3.2.1.156]", "canonical_name": "beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity"}
{"concept_id": "C2247472", "aliases": ["iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity"], "types": ["T044"], "canonical_name": "iota-carrageenase activity", "definition": "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans. [EC:3.2.1.157]"}
{"concept_id": "C2247473", "aliases": [], "types": ["T044"], "canonical_name": "alpha-agarase activity", "definition": "Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product. [EC:3.2.1.158]"}
{"concept_id": "C2247474", "aliases": [], "types": ["T044"], "canonical_name": "agarase A33 activity"}
{"concept_id": "C2247475", "aliases": ["alpha-neoagarooligosaccharide hydrolase activity", "alpha-NAOS hydrolase activity", "alpha-neoagaro-oligosaccharide 3-glycohydrolase activity"], "types": ["T044"], "canonical_name": "alpha-neoagaro-oligosaccharide hydrolase activity", "definition": "Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose. [EC:3.2.1.159]"}
{"concept_id": "C2247479", "aliases": ["isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity", "furcatin hydrolase activity", "7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity", "isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity"], "types": ["T044"], "canonical_name": "beta-apiosyl-beta-glucosidase activity", "definition": "Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose. [EC:3.2.1.161]"}
{"concept_id": "C2247480", "aliases": ["endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity"], "types": ["T044"], "canonical_name": "lambda-carrageenase activity", "definition": "Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S. [EC:3.2.1.162]"}
{"concept_id": "C2247481", "aliases": ["hypoxanthine-DNA glycosylase activity", "DNA(hypoxanthine) glycohydrolase activity", "deoxyribonucleic acid glycosylase activity", "DNA-deoxyinosine glycosidase activity", "DNA-deoxyinosine deoxyribohydrolase activity"], "types": ["T045"], "canonical_name": "DNA-deoxyinosine glycosylase activity", "definition": "Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine. [EC:3.2.2.15]"}
{"concept_id": "C2247482", "aliases": ["deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity", "T4-induced UV endonuclease activity", "pyrimidine dimer DNA-glycosylase activity", "PD-DNA glycosylase activity", "pyrimidine dimer DNA glycosylase activity", "deoxyribonucleate pyrimidine dimer glycosidase activity"], "types": ["T045"], "canonical_name": "deoxyribodipyrimidine endonucleosidase activity", "definition": "Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue. [EC:3.2.2.17]"}
{"concept_id": "C2247483", "aliases": ["N-methyl nucleoside hydrolase activity", "7-methylxanthosine ribohydrolase activity", "methylpurine nucleosidase activity", "N-MeNase activity", "7-methylxanthosine nucleosidase activity"], "types": ["T044"], "canonical_name": "N-methyl nucleosidase activity", "definition": "Catalysis of the reaction: 7-methylxanthosine + H(2)O = 7-methylxanthine + H(+) + ribofuranose. [EC:3.2.2.25, RHEA:10880]"}
{"concept_id": "C2247484", "aliases": ["mEH", "cis-epoxide hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol. [EC:3.3.2.9]", "canonical_name": "cis-stilbene-oxide hydrolase activity"}
{"concept_id": "C2247485", "aliases": ["arene-oxide hydratase activity"], "types": ["T044"], "canonical_name": "arene-oxide hydratase activity"}
{"concept_id": "C2247486", "aliases": ["aryl epoxide hydrase activity"], "types": ["T044"], "canonical_name": "aryl epoxide hydrase activity"}
{"concept_id": "C2247487", "aliases": [], "types": ["T044"], "canonical_name": "benzo(a)pyrene-4,5-epoxide hydratase activity"}
{"concept_id": "C2247488", "aliases": [], "types": ["T044"], "canonical_name": "benzo[a]pyrene-4,5-oxide hydratase activity"}
{"concept_id": "C2247489", "aliases": ["epoxide hydrase activity"], "types": ["T044"], "canonical_name": "epoxide hydrase activity"}
{"concept_id": "C2247490", "aliases": ["epoxide hydratase activity"], "types": ["T044"], "canonical_name": "epoxide hydratase activity"}
{"concept_id": "C2247491", "aliases": [], "types": ["T044"], "canonical_name": "microsomal epoxide hydrase activity"}
{"concept_id": "C2247492", "aliases": ["microsomal epoxide hydrolase activity"], "types": ["T044"], "canonical_name": "microsomal epoxide hydratase activity"}
{"concept_id": "C2247494", "aliases": ["cytoplasmic mRNA processing body assembly", "P body assembly"], "types": ["T043"], "canonical_name": "P-body assembly", "definition": "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. [GOC:mah, PMID:17429074]"}
{"concept_id": "C2247495", "aliases": [], "types": ["T044"], "canonical_name": "P body biogenesis"}
{"concept_id": "C2247496", "aliases": ["cholesterol-epoxide hydrolase activity", "ChEH", "5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity"], "types": ["T044"], "canonical_name": "cholesterol-5,6-oxide hydrolase activity", "definition": "Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol. [EC:3.3.2.11]"}
{"concept_id": "C2247497", "aliases": ["glycosphingolipid amidohydrolase activity"], "types": ["T044"], "canonical_name": "glycosphingolipid deacylase activity", "definition": "Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives. [EC:3.5.1.69]"}
{"concept_id": "C2247498", "aliases": ["glycosphingolipid ceramide deacylase"], "types": ["T044"], "canonical_name": "glycosphingolipid ceramide deacylase activity"}
{"concept_id": "C2247499", "aliases": ["aculeacin-A amidohydrolase activity", "aculeacin A acylase activity"], "types": ["T044"], "canonical_name": "aculeacin-A deacylase activity", "definition": "Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain. [EC:3.5.1.70]"}
{"concept_id": "C2247500", "aliases": ["NfdA", "N-benzylformamide amidohydrolase activity"], "types": ["T044"], "canonical_name": "N-substituted formamide deformylase activity", "definition": "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine. [EC:3.5.1.91]"}
{"concept_id": "C2247501", "aliases": [], "types": ["T045"], "canonical_name": "box C/D snoRNA metabolic process"}
{"concept_id": "C2247502", "aliases": ["4-(glutamylamino)butanoate amidohydrolase activity", "gamma-glutamyl-GABA hydrolase activity", "PuuD", "YcjL"], "types": ["T044"], "canonical_name": "gamma-glutamyl-gamma-aminobutyrate hydrolase activity", "definition": "Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H(2)O = 4-aminobutanoate + L-glutamate. [EC:3.5.1.94, RHEA:19737]"}
{"concept_id": "C2247503", "aliases": ["ureidomalonase activity", "3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity"], "types": ["T044"], "canonical_name": "N-malonylurea hydrolase activity", "definition": "Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H(2)O = H(+) + malonate + urea. [EC:3.5.1.95, RHEA:17361]"}
{"concept_id": "C2247504", "aliases": ["HIUHase activity", "5-hydroxyisourate hydrolase activity", "5-hydroxyisourate amidohydrolase activity"], "types": ["T044"], "canonical_name": "hydroxyisourate hydrolase activity", "definition": "Catalysis of the reaction: 5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+). [EC:3.5.2.17, RHEA:23736]"}
{"concept_id": "C2247505", "aliases": ["PAH", "proclavaminate amidinohydrolase activity", "proclavaminate amidino hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: amidinoproclavaminate + H(2)O = proclavaminate + urea. [EC:3.5.3.22, RHEA:17001]", "canonical_name": "proclavaminic acid amidino hydrolase activity"}
{"concept_id": "C2247506", "aliases": ["dCTP aminohydrolase (dUMP-forming) activity"], "types": ["T044"], "canonical_name": "dCTP deaminase (dUMP-forming) activity", "definition": "Catalysis of the reaction: dCTP + 2 H(2)O = diphosphate + dUMP + H(+) + NH(4)(+). [EC:3.5.4.30, RHEA:19205]"}
{"concept_id": "C2247507", "aliases": ["nucleoside-5'-phosphoacylate acylhydrolase activity"], "types": ["T044"], "canonical_name": "nucleoside phosphoacylhydrolase activity", "definition": "Catalysis of the hydrolysis of mixed phospho-anhydride bonds. [EC:3.6.1.24]"}
{"concept_id": "C2247508", "aliases": ["D-DEX", "D-2-haloacid dehalogenase activity", "(R)-2-haloacid halidohydrolase activity"], "types": ["T044"], "canonical_name": "(R)-2-haloacid dehalogenase activity", "definition": "Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide. [EC:3.8.1.9]"}
{"concept_id": "C2247509", "aliases": ["DL-2-haloacid halidohydrolase (inversion of configuration) activity", "DL-2-haloacid dehalogenase (inversion of configuration) activity"], "types": ["T044"], "canonical_name": "2-haloacid dehalogenase (configuration-inverting) activity", "definition": "Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide. [GOC:curators]"}
{"concept_id": "C2247510", "aliases": [], "types": ["T044"], "canonical_name": "DL-DEXi"}
{"concept_id": "C2247511", "aliases": [], "types": ["T044"], "canonical_name": "2-haloacid dehalogenase (configuration-retaining) activity", "definition": "Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide. [RHEA:12072]"}
{"concept_id": "C2247512", "aliases": [], "types": ["T044"], "canonical_name": "DL-DEXr"}
{"concept_id": "C2247513", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA snoRNA metabolic process"}
{"concept_id": "C2247514", "aliases": ["3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity", "3-phosphonopyruvate carboxy-lyase activity"], "types": ["T044"], "canonical_name": "phosphonopyruvate decarboxylase activity", "definition": "Catalysis of the reaction: 3-phosphonopyruvate + 2 H(+) = CO(2) + phosphonoacetaldehyde. [EC:4.1.1.82, RHEA:20768]"}
{"concept_id": "C2247515", "aliases": ["D-dopachrome carboxy-lyase activity", "dopachrome decarboxylase activity", "D-tautomerase activity", "phenylpyruvate tautomerase II activity", "D-dopachrome decarboxylase activity", "dopachrome conversion activity", "D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2). [EC:4.1.1.84, RHEA:18441]", "canonical_name": "D-dopachrome tautomerase activity"}
{"concept_id": "C2247516", "aliases": ["UlaD", "3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity", "3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity", "3-keto-L-gulonate 6-phosphate decarboxylase activity", "KGPDC", "SgaH", "SgbH"], "types": ["T044"], "canonical_name": "3-dehydro-L-gulonate-6-phosphate decarboxylase activity", "definition": "Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H(+) = L-xylulose 5-phosphate + CO(2). [EC:4.1.1.85, RHEA:14353]"}
{"concept_id": "C2247517", "aliases": ["DABA DC", "L-2,4-diaminobutyrate decarboxylase activity", "L-2,4-diaminobutanoate carboxy-lyase activity", "L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity"], "types": ["T044"], "canonical_name": "diaminobutyrate decarboxylase activity", "definition": "Catalysis of the reaction: L-2,4-diaminobutyrate + H(+) = 1,3-diaminopropane + CO(2). [EC:4.1.1.86, RHEA:15689]"}
{"concept_id": "C2247518", "aliases": ["indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity", "TSA", "BX1", "indole synthase activity", "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity", "indoleglycerolphosphate aldolase activity", "indole glycerol phosphate hydrolase activity", "indole-3-glycerol phosphate lyase activity", "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity", "IGL"], "types": ["T044"], "definition": "Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate. [EC:4.1.2.8]", "canonical_name": "indole-3-glycerol-phosphate lyase activity"}
{"concept_id": "C2247519", "aliases": [], "types": ["T026"], "canonical_name": "acidocalcisome lumen", "definition": "The volume enclosed by the membranes of an acidocalcisome. [GOC:mah]"}
{"concept_id": "C2247520", "aliases": [], "types": ["T043"], "canonical_name": "response to methanol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus. [GOC:sl]"}
{"concept_id": "C2247521", "aliases": ["2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity", "2,7,4'-trihydroxyisoflavanone hydro-lyase activity"], "types": ["T044"], "canonical_name": "2-hydroxyisoflavanone dehydratase activity", "definition": "Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O. [EC:4.2.1.105]"}
{"concept_id": "C2247522", "aliases": ["7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity", "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity", "BA7 alpha dehydratase activity"], "types": ["T044"], "canonical_name": "bile-acid 7alpha-dehydratase activity", "definition": "Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(2)O. [PMID:26650892, RHEA:10436]"}
{"concept_id": "C2247523", "aliases": ["(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity", "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity", "46 kDa hydratase 2 activity"], "types": ["T044"], "canonical_name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity", "definition": "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O. [EC:4.2.1.107]"}
{"concept_id": "C2247524", "aliases": ["D-3-hydroxyacyl-CoA dehydratase"], "types": ["T044"], "canonical_name": "D-3-hydroxyacyl-CoA dehydratase activity"}
{"concept_id": "C2247525", "aliases": ["4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity", "N-acetyldiaminobutyrate dehydratase activity", "L-ectoine synthase activity", "N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity", "EctC", "N-acetyldiaminobutanoate dehydratase activity"], "types": ["T044"], "canonical_name": "ectoine synthase activity", "definition": "Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H(2)O. [EC:4.2.1.108, RHEA:17281]"}
{"concept_id": "C2247526", "aliases": ["1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity", "AUDH", "1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity", "pyranosone dehydratase activity"], "types": ["T044"], "canonical_name": "aldos-2-ulose dehydratase activity", "definition": "Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one. [EC:4.2.1.110]"}
{"concept_id": "C2247527", "aliases": ["AFDH", "1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity", "1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity", "AF dehydratase activity", "1,5-anhydro-D-fructose 4-dehydratase activity", "1,5-anhydro-D-fructose hydro-lyase activity", "1,5-anhydro-D-fructose hydrolyase activity"], "types": ["T044"], "canonical_name": "1,5-anhydro-D-fructose dehydratase activity", "definition": "Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O. [EC:4.2.1.111]"}
{"concept_id": "C2247528", "aliases": [], "types": ["T043"], "canonical_name": "response to lipid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. [GOC:sl]"}
{"concept_id": "C2247529", "aliases": ["(1,4)-beta-D-glucuronan lyase activity"], "types": ["T044"], "canonical_name": "glucuronan lyase activity", "definition": "Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides. [EC:4.2.2.14]"}
{"concept_id": "C2247530", "aliases": ["anhydroneuraminidase activity", "sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity", "glycoconjugate sialyl-lyase (2,7-cyclizing) activity", "sialidase L activity"], "types": ["T044"], "canonical_name": "anhydrosialidase activity", "definition": "Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate. [EC:4.2.2.15]"}
{"concept_id": "C2247531", "aliases": ["2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity", "levan fructotransferase activity", "2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity"], "types": ["T044"], "canonical_name": "levan fructotransferase (DFA-IV-forming) activity", "definition": "Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide. [EC:4.2.2.16]"}
{"concept_id": "C2247532", "aliases": ["inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity", "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity", "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity", "inulin fructotransferase (DFA-I-producing) activity", "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity"], "types": ["T044"], "canonical_name": "inulin fructotransferase (DFA-I-forming) activity", "definition": "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide. [EC:4.2.2.17]"}
{"concept_id": "C2247533", "aliases": ["inulinase II activity", "inulin fructotransferase (depolymerizing) activity", "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity", "inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity", "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity", "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity", "inulase II activity", "inulin fructotransferase (DFA-III-producing) activity"], "types": ["T044"], "canonical_name": "inulin fructotransferase (DFA-III-forming) activity", "definition": "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide. [EC:4.2.2.18]"}
{"concept_id": "C2247534", "aliases": ["chonB", "ChnB", "chondroitinase B activity", "dermatan sulfate lyase activity"], "types": ["T044"], "canonical_name": "chondroitin B lyase activity", "definition": "Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate. [EC:4.2.2.19]"}
{"concept_id": "C2247535", "aliases": ["ChS ABC lyase I activity", "chondroitin-sulfate-ABC endolyase activity", "chondroitinase ABC activity", "chondroitin sulfate ABC endoeliminase activity"], "types": ["T044"], "definition": "Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides. [EC:4.2.2.20]", "canonical_name": "chondroitin sulfate ABC endolyase activity"}
{"concept_id": "C2247536", "aliases": ["chondroitin ABC eliminase activity"], "types": ["T044"], "canonical_name": "chondroitin ABC eliminase activity"}
{"concept_id": "C2247537", "aliases": ["chondroitin sulfate ABC lyase activity", "ChS ABC lyase activity"], "types": ["T044"], "canonical_name": "chondroitin sulfate ABC lyase activity"}
{"concept_id": "C2247540", "aliases": ["chondroitin sulfate ABC exolyase activity", "ChS ABC lyase II activity", "chondroitin-sulfate-ABC exolyase activity", "chondroitinase ABC activity"], "types": ["T044"], "definition": "Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments. [EC:4.2.2.21]", "canonical_name": "chondroitin sulfate ABC exoeliminase activity"}
{"concept_id": "C2247541", "aliases": ["geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity", "geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity", "(+)-limonene synthase activity"], "types": ["T044"], "canonical_name": "(R)-limonene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate. [EC:4.2.3.20, RHEA:10940]"}
{"concept_id": "C2247542", "aliases": ["pemnaspirodiene synthase activity", "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity", "vetispiradiene cyclase activity", "vetispiradiene synthase activity", "HVS"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene. [EC:4.2.3.21, RHEA:10340]", "canonical_name": "vetispiradiene-forming farnesyl pyrophosphate cyclase activity"}
{"concept_id": "C2247543", "aliases": ["2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity"], "types": ["T044"], "canonical_name": "germacradienol synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate. [EC:4.2.3.22]"}
{"concept_id": "C2247544", "aliases": ["2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity", "amorphadiene synthase activity"], "types": ["T044"], "canonical_name": "amorpha-4,11-diene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate. [EC:4.2.3.24, RHEA:18325]"}
{"concept_id": "C2247545", "aliases": ["geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity", "LIS", "3S-linalool synthase activity"], "types": ["T044"], "canonical_name": "S-linalool synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate + H(2)O = (S)-linalool + diphosphate. [EC:4.2.3.25, RHEA:24116]"}
{"concept_id": "C2247546", "aliases": ["(-)-3R-linalool synthase activity", "geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity", "(3R)-linalool synthase activity"], "types": ["T044"], "canonical_name": "R-linalool synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate + H(2)O = (R)-linalool + diphosphate. [EC:4.2.3.26, RHEA:15809]"}
{"concept_id": "C2247547", "aliases": ["ISPS", "ISPC", "dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity"], "types": ["T044"], "canonical_name": "isoprene synthase activity", "definition": "Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene. [EC:4.2.3.27, RHEA:13369]"}
{"concept_id": "C2247548", "aliases": ["3-sulfolactate bisulfite-lyase activity", "Suy", "SuyAB", "3-sulfolactate bisulfite-lyase (pyruvate-forming) activity"], "types": ["T044"], "canonical_name": "sulfolactate sulfo-lyase activity", "definition": "Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite. [EC:4.4.1.24, RHEA:21428]"}
{"concept_id": "C2247549", "aliases": ["CuyA", "L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity", "L-cysteate sulfo-lyase (deaminating) activity"], "types": ["T044"], "canonical_name": "L-cysteate sulfo-lyase activity", "definition": "Catalysis of the reaction: L-cysteate + H(2)O = NH(4)(+) + pyruvate + sulfite. [EC:4.4.1.25, RHEA:13441]"}
{"concept_id": "C2247550", "aliases": ["FMN cyclase activity", "FAD AMP-lyase (cyclic-FMN-forming) activity", "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity"], "types": ["T044"], "canonical_name": "FAD-AMP lyase (cyclizing) activity", "definition": "Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate. [EC:4.6.1.15]"}
{"concept_id": "C2247551", "aliases": ["aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity", "aliphatic aldoxime hydro-lyase activity", "aliphatic aldoxime dehydratase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O. [EC:4.99.1.5]", "canonical_name": "OxdA"}
{"concept_id": "C2247552", "aliases": ["response to triacylglycerol", "response to triacylglyceride"], "types": ["T043"], "canonical_name": "response to triglyceride", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus. [GOC:sl]"}
{"concept_id": "C2247553", "aliases": ["UlaE", "L-xylulose 5-phosphate 3-epimerase activity", "SgaU"], "types": ["T044"], "canonical_name": "L-ribulose-5-phosphate 3-epimerase activity", "definition": "Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate. [EC:5.1.3.22, RHEA:18497]"}
{"concept_id": "C2247554", "aliases": ["(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity", "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity", "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity", "PFI", "eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity"], "types": ["T044"], "canonical_name": "polyenoic fatty acid isomerase activity", "definition": "Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate. [RHEA:14889]"}
{"concept_id": "C2247556", "aliases": ["ascopyrone isomerase activity", "APTM", "ascopyrone intramolecular oxidoreductase activity", "1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity", "1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity", "ascopyrone P tautomerase activity", "APM tautomerase activity"], "types": ["T044"], "canonical_name": "ascopyrone tautomerase activity", "definition": "Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose. [EC:5.3.2.7]"}
{"concept_id": "C2247557", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reactions: violaxanthin = capsorubin, and antheraxanthin = capsanthin. [EC:5.3.99.8]", "canonical_name": "capsanthin-capsorubin synthase activity"}
{"concept_id": "C2247558", "aliases": ["NSY", "violaxanthin-neoxanthin isomerase (epoxide-opening) activity"], "types": ["T044"], "canonical_name": "neoxanthin synthase activity", "definition": "Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin. [EC:5.3.99.9, RHEA:10128]"}
{"concept_id": "C2247559", "aliases": ["response to silox", "response to silica"], "types": ["T043"], "canonical_name": "response to silicon dioxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus. [GOC:sl]"}
{"concept_id": "C2247560", "aliases": ["3-hydroxylaminophenol mutase activity", "3HAP mutase activity", "3-(hydroxyamino)phenol hydroxymutase activity"], "types": ["T044"], "canonical_name": "3-(hydroxyamino)phenol mutase activity", "definition": "Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone. [EC:5.4.4.3, RHEA:20577]"}
{"concept_id": "C2247561", "aliases": ["5-(carboxyamino)imidazole ribonucleotide mutase activity", "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity", "N5-carboxyaminoimidazole ribonucleotide mutase activity", "PurE"], "types": ["T044"], "definition": "Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. [EC:5.4.99.18]", "canonical_name": "N5-CAIR mutase activity"}
{"concept_id": "C2247562", "aliases": [], "types": ["T044"], "canonical_name": "class I PurE"}
{"concept_id": "C2247563", "aliases": ["L-glutamate:putrescine ligase (ADP-forming) activity", "gamma-glutamylputrescine synthetase activity", "YcjK"], "types": ["T044"], "canonical_name": "glutamate-putrescine ligase activity", "definition": "Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H(+) + phosphate. [EC:6.3.1.11, RHEA:13633]"}
{"concept_id": "C2247564", "aliases": ["aslfm", "D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity", "UDP-MurNAc-pentapeptide:D-aspartate ligase activity"], "types": ["T044"], "canonical_name": "D-aspartate ligase activity", "definition": "Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate. [EC:6.3.1.12]"}
{"concept_id": "C2247565", "aliases": [], "types": ["T044"], "canonical_name": "D-aspartic acid-activating enzyme"}
{"concept_id": "C2247566", "aliases": ["YwfE", "bacilysin synthetase activity", "L-amino acid alpha-ligase activity", "L-amino acid ligase activity"], "types": ["T044"], "canonical_name": "L-amino-acid alpha-ligase activity", "definition": "Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid. [EC:6.3.2.49]"}
{"concept_id": "C2247567", "aliases": ["L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity", "L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity", "beta-lactam synthetase activity"], "types": ["T044"], "canonical_name": "(carboxyethyl)arginine beta-lactam-synthase activity", "definition": "Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H(+). [EC:6.3.3.4, RHEA:23620]"}
{"concept_id": "C2247568", "aliases": ["PurK", "N5-CAIR synthetase activity", "N5-carboxyaminoimidazole ribonucleotide synthetase activity", "5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity"], "types": ["T044"], "canonical_name": "5-(carboxyamino)imidazole ribonucleotide synthase activity", "definition": "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate. [EC:6.3.4.18, RHEA:19317]"}
{"concept_id": "C2247569", "aliases": [], "types": ["T044"], "canonical_name": "carboxylating factor for ICDH"}
{"concept_id": "C2247570", "aliases": ["ribonucleoside bisphosphate biosynthesis", "ribonucleoside bisphosphate formation", "ribonucleoside bisphosphate anabolism", "ribonucleoside bisphosphate synthesis"], "types": ["T044"], "canonical_name": "ribonucleoside bisphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247571", "aliases": ["ribonucleoside bisphosphate degradation", "ribonucleoside bisphosphate catabolism", "ribonucleoside bisphosphate breakdown"], "types": ["T045"], "canonical_name": "ribonucleoside bisphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247572", "aliases": ["purine nucleoside bisphosphate metabolism"], "types": ["T044"], "canonical_name": "purine nucleoside bisphosphate metabolic process", "definition": "The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247573", "aliases": ["purine nucleoside bisphosphate synthesis", "purine nucleoside bisphosphate formation", "purine nucleoside bisphosphate biosynthesis", "purine nucleoside bisphosphate anabolism"], "types": ["T044"], "canonical_name": "purine nucleoside bisphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247574", "aliases": ["purine nucleoside bisphosphate degradation", "purine nucleoside bisphosphate breakdown", "purine nucleoside bisphosphate catabolism"], "types": ["T044"], "canonical_name": "purine nucleoside bisphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247575", "aliases": ["purine ribonucleoside bisphosphate metabolism"], "types": ["T045"], "canonical_name": "purine ribonucleoside bisphosphate metabolic process", "definition": "The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247576", "aliases": ["purine ribonucleoside bisphosphate biosynthesis", "purine ribonucleoside bisphosphate anabolism", "purine ribonucleoside bisphosphate synthesis", "purine ribonucleoside bisphosphate formation"], "types": ["T045"], "canonical_name": "purine ribonucleoside bisphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247577", "aliases": ["purine ribonucleoside bisphosphate breakdown", "purine ribonucleoside bisphosphate catabolism", "purine ribonucleoside bisphosphate degradation"], "types": ["T044"], "canonical_name": "purine ribonucleoside bisphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. [GOC:mah, GOC:pde]"}
{"concept_id": "C2247578", "aliases": ["8-oxoG DNA N-glycosylase activity"], "types": ["T045"], "canonical_name": "8-oxo-7,8-dihydroguanine DNA N-glycosylase activity", "definition": "Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. [GOC:mah, PMID:17641464]"}
{"concept_id": "C2247579", "aliases": [], "types": ["T044"], "canonical_name": "lipid-transporting ATPase activity"}
{"concept_id": "C2247580", "aliases": [], "types": ["T044"], "canonical_name": "sterol-transporting ATPase activity"}
{"concept_id": "C2247581", "aliases": ["5-foU DNA N-glycosylase activity"], "types": ["T045"], "canonical_name": "5-formyluracil DNA N-glycosylase activity", "definition": "Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. [GOC:mah, PMID:17641464]"}
{"concept_id": "C2247582", "aliases": ["5-hmU DNA N-glycosylase activity"], "types": ["T045"], "canonical_name": "5-hydroxymethyluracil DNA N-glycosylase activity", "definition": "Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. [GOC:mah, PMID:17641464]"}
{"concept_id": "C2247583", "aliases": ["exomer complex location"], "types": ["T026"], "canonical_name": "exomer complex", "definition": "A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues. [PMID:16498409, PMID:17000877]"}
{"concept_id": "C2247584", "aliases": ["PAS membrane", "pre-autophagosomal structure membrane"], "types": ["T026"], "canonical_name": "phagophore assembly site membrane", "definition": "A cellular membrane associated with the phagophore assembly site. [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324]"}
{"concept_id": "C2247585", "aliases": ["isolation membrane"], "types": ["T026"], "canonical_name": "isolation membrane"}
{"concept_id": "C2247586", "aliases": ["poly(rG) binding", "poly(G) binding, within an RNA molecule"], "types": ["T045"], "canonical_name": "poly(G) binding", "definition": "Binding to a sequence of guanine residues in an RNA molecule. [GOC:mah]"}
{"concept_id": "C2247588", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein phosphatase type 2A activity"}
{"concept_id": "C2247590", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein phosphatase type 2A activity"}
{"concept_id": "C2247592", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein phosphatase type 2A activity"}
{"concept_id": "C2247593", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of protein phosphatase type 2A activity"}
{"concept_id": "C2247594", "aliases": ["'host programmed cell death induced by symbiont'"], "types": ["T043"], "canonical_name": "programmed cell death induced by symbiont", "definition": "Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules. [GOC:pamgo_curators]"}
{"concept_id": "C2247595", "aliases": ["down-regulation of plant-type hypersensitive response", "negative regulation of plant hypersensitive response", "negative regulation of HR", "negative regulation of HR-PCD", "downregulation of plant-type hypersensitive response", "down regulation of plant-type hypersensitive response"], "types": ["T043"], "canonical_name": "negative regulation of plant-type hypersensitive response", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the hypersensitive response in a plant. [GOC:pamgo_curators]"}
{"concept_id": "C2247596", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of plant-type hypersensitive response"}
{"concept_id": "C2247597", "aliases": ["up-regulation of plant-type hypersensitive response", "up regulation of plant-type hypersensitive response", "positive regulation of plant hypersensitive response", "upregulation of plant-type hypersensitive response", "positive regulation of HR"], "types": ["T043"], "canonical_name": "positive regulation of plant-type hypersensitive response", "definition": "Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant. [GOC:pamgo_curators]"}
{"concept_id": "C2247598", "aliases": [], "types": ["T043"], "canonical_name": "activation of plant-type hypersensitive response"}
{"concept_id": "C2247599", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of HR-PCD"}
{"concept_id": "C2247600", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of plant-type hypersensitive response"}
{"concept_id": "C2247601", "aliases": ["modulation by symbiont of host defense-related PCD"], "types": ["T040"], "canonical_name": "modulation by symbiont of host defense-related programmed cell death", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247602", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host HR"}
{"concept_id": "C2247603", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host hypersensitive response"}
{"concept_id": "C2247604", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of plant HR"}
{"concept_id": "C2247605", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of plant hypersensitive response"}
{"concept_id": "C2247607", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host defense-related PCD"}
{"concept_id": "C2247608", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host defense-related programmed cell death"}
{"concept_id": "C2247609", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of host defense-related PCD"}
{"concept_id": "C2247610", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of HR"}
{"concept_id": "C2247611", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of hypersensitive response"}
{"concept_id": "C2247612", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of plant HR"}
{"concept_id": "C2247613", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of plant hypersensitive response"}
{"concept_id": "C2247614", "aliases": ["negative regulation by symbiont of host defense-related PCD", "negative regulation by symbiont of host defense-related programmed cell death", "down regulation by symbiont of host defense-related programmed cell death", "down-regulation by symbiont of host defense-related programmed cell death", "downregulation by symbiont of host defense-related programmed cell death"], "types": ["T040"], "canonical_name": "suppression by symbiont of host defense-related programmed cell death", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247615", "aliases": [], "types": ["T040"], "canonical_name": "suppression of HR"}
{"concept_id": "C2247616", "aliases": ["positive regulation by symbiont of host defense-related PCD", "positive regulation by symbiont of host defense-related programmed cell death", "upregulation by symbiont of host defense-related programmed cell death", "up-regulation by symbiont of host defense-related programmed cell death", "up regulation by symbiont of host defense-related programmed cell death"], "types": ["T040"], "canonical_name": "effector-mediated induction of programmed cell death in host", "definition": "A symbiont process in which a molecule secreted by the symbiont activates a programmed cell death pathway in the host to suppress the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2247617", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of host defense-related programmed cell death"}
{"concept_id": "C2247623", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host defense-related programmed cell death"}
{"concept_id": "C2247624", "aliases": ["ERE binding"], "types": ["T045"], "canonical_name": "estrogen response element binding", "definition": "Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. [GOC:ecd, PMID:15036253, PMID:17975005]"}
{"concept_id": "C2247625", "aliases": [], "types": ["T045"], "canonical_name": "RNA strand-exchange activity", "definition": "Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity. [GOC:mcc, PMID:9769100]"}
{"concept_id": "C2247626", "aliases": ["endosome vesicle fusion"], "types": ["T043"], "canonical_name": "endosomal vesicle fusion", "definition": "The homotypic fusion of endocytic vesicles to form or add to an early endosome. [PMID:11964142, PMID:9422733]"}
{"concept_id": "C2247627", "aliases": ["response to anoxic stress"], "types": ["T040"], "canonical_name": "response to anoxia", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. [GOC:kmv]"}
{"concept_id": "C2247628", "aliases": [], "types": ["T026"], "canonical_name": "cyanelle stroma", "definition": "The space enclosed by the double membrane of a cyanelle. [GOC:rph]"}
{"concept_id": "C2247629", "aliases": ["DNA nucleotidyltransferase activity", "deoxyribonucleic polymerase activity", "deoxyribonucleic acid polymerase activity", "deoxyribonucleate nucleotidyltransferase activity", "deoxynucleate polymerase activity"], "types": ["T045"], "canonical_name": "DNA polymerase activity", "definition": "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. [EC:2.7.7.7, GOC:mah]"}
{"concept_id": "C2247630", "aliases": ["RNA nucleotidyltransferase activity", "ribonucleic polymerase activity", "ribonucleic acid transcriptase activity", "ribonucleic acid polymerase activity", "5'-3' RNA polymerase activity", "RNA transcriptase activity", "RNA polymerase activity", "ribonucleic transcriptase activity", "ribonucleate polymerase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end. [EC:2.7.7.6, GOC:mah, GOC:pf]", "canonical_name": "ribonucleate nucleotidyltransferase activity"}
{"concept_id": "C2247631", "aliases": ["C ribonucleic acid formation factors"], "types": ["T045"], "canonical_name": "C ribonucleic acid formation factors"}
{"concept_id": "C2247632", "aliases": ["C RNA formation factors"], "types": ["T045"], "canonical_name": "C RNA formation factors"}
{"concept_id": "C2247633", "aliases": [], "types": ["T044"], "canonical_name": "ribonucleic acid nucleotidyltransferase"}
{"concept_id": "C2247634", "aliases": ["SG assembly"], "types": ["T045"], "canonical_name": "stress granule assembly", "definition": "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. [GOC:mah, PMID:17392519]"}
{"concept_id": "C2247635", "aliases": ["Tor2-Mei2-Ste11 complex location"], "types": ["T026"], "canonical_name": "Tor2-Mei2-Ste11 complex", "definition": "A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast. [GOC:vw, PMID:17046992]"}
{"concept_id": "C2247637", "aliases": ["Ric1p-Rgp1p complex location"], "types": ["T026"], "canonical_name": "Ric1p-Rgp1p complex"}
{"concept_id": "C2247638", "aliases": ["protein localization in Golgi apparatus", "protein localisation in Golgi apparatus"], "types": ["T043"], "canonical_name": "protein localization to Golgi apparatus", "definition": "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. [GOC:mah]"}
{"concept_id": "C2247639", "aliases": [], "types": ["T044"], "canonical_name": "aminoglycoside nucleotidyltransferase activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside. [GOC:cb]"}
{"concept_id": "C2247640", "aliases": [], "types": ["T044"], "canonical_name": "aminoglycoside adenylyltransferase activity"}
{"concept_id": "C2247641", "aliases": [], "types": ["T044"], "canonical_name": "streptomycin adenylate synthetase activity"}
{"concept_id": "C2247642", "aliases": [], "types": ["T044"], "canonical_name": "streptomycin adenyltransferase activity"}
{"concept_id": "C2247643", "aliases": [], "types": ["T044"], "canonical_name": "streptomycin adenylylase activity"}
{"concept_id": "C2247644", "aliases": [], "types": ["T044"], "canonical_name": "streptomycin adenylyltransferase activity"}
{"concept_id": "C2247645", "aliases": [], "types": ["T044"], "canonical_name": "streptomycin-spectinomycin adenylyltransferase activity"}
{"concept_id": "C2247646", "aliases": [], "types": ["T044"], "canonical_name": "aminoglycoside N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside. [GOC:cb]"}
{"concept_id": "C2247647", "aliases": [], "types": ["T044"], "canonical_name": "kanamycin acetyltransferase activity"}
{"concept_id": "C2247648", "aliases": [], "types": ["T044"], "canonical_name": "aminoglycoside 1-N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring. [GOC:cb]"}
{"concept_id": "C2247649", "aliases": ["aminoglycoside kinase activity"], "types": ["T044"], "canonical_name": "aminoglycoside phosphotransferase activity", "definition": "Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside. [GOC:cb, GOC:mah]"}
{"concept_id": "C2247650", "aliases": [], "types": ["T044"], "canonical_name": "squalene cyclase activity", "definition": "Catalysis of the reaction: squalene = triterpene. [GOC:cb, PMID:18033581]"}
{"concept_id": "C2247651", "aliases": [], "types": ["T044"], "canonical_name": "tetrahymanol cyclase activity", "definition": "Catalysis of the reaction: squalene = tetrahymanol. [GOC:cb, PMID:18033581]"}
{"concept_id": "C2247652", "aliases": [], "types": ["T044"], "canonical_name": "marneral synthase activity", "definition": "Catalysis of the reaction: oxidosqualene = marneral. [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581]"}
{"concept_id": "C2247653", "aliases": [], "types": ["T044"], "canonical_name": "arabidiol synthase activity", "definition": "Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol). [GOC:cb, PMID:16774269, PMID:17474751]"}
{"concept_id": "C2247654", "aliases": [], "types": ["T044"], "canonical_name": "cucurbitadienol synthase activity", "definition": "Catalysis of the reaction: oxidosqualene = cucurbitadienol. [GOC:cb, PMID:18033581]"}
{"concept_id": "C2247655", "aliases": ["butylene glycol metabolism", "butanediol metabolism", "butylene glycol metabolic process"], "types": ["T044"], "canonical_name": "butanediol metabolic process", "definition": "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3. [ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY]"}
{"concept_id": "C2247656", "aliases": ["butanediol breakdown", "butylene glycol catabolic process", "butylene glycol catabolism", "butanediol catabolism", "butanediol degradation"], "types": ["T044"], "canonical_name": "butanediol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3. [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL]"}
{"concept_id": "C2247657", "aliases": [], "types": ["T044"], "canonical_name": "butanediol utilization"}
{"concept_id": "C2247658", "aliases": ["butylene glycol biosynthesis", "butylene glycol biosynthetic process", "butanediol synthesis", "butanediol biosynthesis", "butanediol anabolism", "butanediol formation"], "types": ["T044"], "canonical_name": "butanediol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3. [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL]"}
{"concept_id": "C2247659", "aliases": ["centromeric DNA replication-independent nucleosome assembly", "CenH3-containing nucleosome assembly at centromere", "CENP-A containing nucleosome assembly at centromere", "DNA replication-independent nucleosome assembly at centromere", "CENP-A containing nucleosome assembly", "centromere-specific histone exchange"], "types": ["T045"], "canonical_name": "CENP-A containing chromatin assembly", "definition": "The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403]"}
{"concept_id": "C2247660", "aliases": ["PKS complex", "PKS complex location", "polyketide synthase complex location", "PKS"], "types": ["T026"], "definition": "A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones. [GOC:mah, PMID:12636085]", "canonical_name": "polyketide synthase complex"}
{"concept_id": "C2247661", "aliases": ["type II PKS complex location", "type II polyketide synthase", "type II PKS", "type II PKS complex", "type II polyketide synthase complex location"], "types": ["T026"], "canonical_name": "type II polyketide synthase complex", "definition": "A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction. [GOC:cb, GOC:mah, PMID:12636085]"}
{"concept_id": "C2247662", "aliases": ["type III PKS", "type III PKS complex location", "type III polyketide synthase complex", "type III polyketide synthase complex location", "type III polyketide synthase"], "types": ["T026"], "definition": "A polyketide synthase complex that consists of two identical ketosynthase polypeptides. [GOC:cb, PMID:12636085]", "canonical_name": "type III PKS complex"}
{"concept_id": "C2247663", "aliases": ["sterol deacetylase activity"], "types": ["T044"], "canonical_name": "steryl deacetylase activity", "definition": "Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol. [GOC:rb, PMID:18034159]"}
{"concept_id": "C2247664", "aliases": [], "types": ["T043"], "canonical_name": "establishment of sister chromatid cohesion", "definition": "The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase. [GOC:jh, GOC:mah, PMID:14623866]"}
{"concept_id": "C2247665", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of sister chromatid cohesion", "definition": "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate. [GOC:mah, PMID:14623866]"}
{"concept_id": "C2247666", "aliases": [], "types": ["T043"], "canonical_name": "establishment of mitotic sister chromatid cohesion", "definition": "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle. [GOC:mah]"}
{"concept_id": "C2247667", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of mitotic sister chromatid cohesion", "definition": "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. [GOC:mah]"}
{"concept_id": "C2247668", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cohesion stability"}
{"concept_id": "C2247669", "aliases": [], "types": ["T043"], "canonical_name": "establishment of meiotic sister chromatid cohesion", "definition": "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle. [GOC:mah]"}
{"concept_id": "C2247670", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of meiotic sister chromatid cohesion", "definition": "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. [GOC:mah]"}
{"concept_id": "C2247671", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maintenance of sister chromatid cohesion", "definition": "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247672", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of maintenance of sister chromatid cohesion", "definition": "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247673", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of maintenance of sister chromatid cohesion", "definition": "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247674", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maintenance of meiotic sister chromatid cohesion", "definition": "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247675", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of maintenance of meiotic sister chromatid cohesion", "definition": "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247676", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of maintenance of meiotic sister chromatid cohesion", "definition": "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247677", "aliases": ["response to cytokine stimulus"], "types": ["T043"], "canonical_name": "response to cytokine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. [GOC:sl]"}
{"concept_id": "C2247678", "aliases": ["Cdc48p-Npl4p-Ufd1p AAA ATPase complex location"], "types": ["T026"], "canonical_name": "Cdc48p-Npl4p-Ufd1p AAA ATPase complex"}
{"concept_id": "C2247679", "aliases": ["luminal surveillance complex location"], "types": ["T026"], "canonical_name": "luminal surveillance complex", "definition": "A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins. [PMID:16873065]"}
{"concept_id": "C2247681", "aliases": ["red blood cell homeostasis", "RBC homeostasis"], "types": ["T039"], "canonical_name": "erythrocyte homeostasis", "definition": "Any process of regulating the production and elimination of erythrocytes within an organism. [GOC:add, PMID:10694114, PMID:14754397]"}
{"concept_id": "C2247682", "aliases": ["red blood cell clearance", "RBC clearance"], "types": ["T039"], "definition": "The selective elimination of erythrocytes from the body by autoregulatory mechanisms. [GOC:add, PMID:12905029, PMID:14754397]", "canonical_name": "erythrocyte clearance"}
{"concept_id": "C2247683", "aliases": [], "types": ["T039"], "canonical_name": "neocytolysis"}
{"concept_id": "C2247684", "aliases": [], "types": ["T039"], "canonical_name": "regulation of tissue remodeling", "definition": "Any process that modulates the frequency, rate, or extent of tissue remodeling. [GOC:add]"}
{"concept_id": "C2247685", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of tissue remodeling", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. [GOC:add]"}
{"concept_id": "C2247686", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of tissue remodeling", "definition": "Any process that activates or increases the frequency, rate, or extent of tissue remodeling. [GOC:add]"}
{"concept_id": "C2247687", "aliases": ["regulation of RBC clearance", "regulation of red blood cell clearance"], "types": ["T039"], "canonical_name": "regulation of erythrocyte clearance", "definition": "Any process that modulates the frequency, rate, or extent of erythrocyte clearance. [GOC:add, PMID:12905029, PMID:14754397]"}
{"concept_id": "C2247688", "aliases": [], "types": ["T039"], "canonical_name": "regulation of neocytolysis"}
{"concept_id": "C2247689", "aliases": ["negative regulation of red blood cell clearance", "negative regulation of RBC clearance"], "types": ["T039"], "canonical_name": "negative regulation of erythrocyte clearance", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance. [GOC:add, PMID:12905029, PMID:14754397]"}
{"concept_id": "C2247690", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of neocytolysis"}
{"concept_id": "C2247691", "aliases": ["positive regulation of RBC clearance", "positive regulation of red blood cell clearance"], "types": ["T039"], "canonical_name": "positive regulation of erythrocyte clearance", "definition": "Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance. [GOC:add, PMID:12905029, PMID:14754397]"}
{"concept_id": "C2247692", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of neocytolysis"}
{"concept_id": "C2247693", "aliases": [], "types": ["T043"], "canonical_name": "homotypic cell-cell adhesion", "definition": "The attachment of a cell to a second cell of the identical type via adhesion molecules. [GOC:add]"}
{"concept_id": "C2247694", "aliases": [], "types": ["T043"], "canonical_name": "regulation of homotypic cell-cell adhesion", "definition": "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion. [GOC:add]"}
{"concept_id": "C2247695", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of homotypic cell-cell adhesion", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion. [GOC:add]"}
{"concept_id": "C2247696", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of homotypic cell-cell adhesion", "definition": "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion. [GOC:add]"}
{"concept_id": "C2247697", "aliases": [], "types": ["T043"], "canonical_name": "heterotypic cell-cell adhesion", "definition": "The attachment of a cell to a cell of a different type via adhesion molecules. [GOC:add]"}
{"concept_id": "C2247698", "aliases": [], "types": ["T043"], "canonical_name": "regulation of heterotypic cell-cell adhesion", "definition": "Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. [GOC:add]"}
{"concept_id": "C2247699", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of heterotypic cell-cell adhesion", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion. [GOC:add]"}
{"concept_id": "C2247700", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of heterotypic cell-cell adhesion", "definition": "Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion. [GOC:add]"}
{"concept_id": "C2247701", "aliases": ["regulation of RBC aggregation", "regulation of red blood cell aggregation"], "types": ["T043"], "canonical_name": "regulation of erythrocyte aggregation", "definition": "Any process that modulates the frequency, rate, or extent of erythrocyte aggregation. [GOC:add]"}
{"concept_id": "C2247702", "aliases": ["negative regulation of red blood cell aggregation", "negative regulation of RBC aggregation"], "types": ["T043"], "canonical_name": "negative regulation of erythrocyte aggregation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte aggregation. [GOC:add]"}
{"concept_id": "C2247703", "aliases": ["positive regulation of red blood cell aggregation", "positive regulation of RBC aggregation"], "types": ["T043"], "canonical_name": "positive regulation of erythrocyte aggregation", "definition": "Any process that activates or increases the frequency, rate, or extent of erythrocyte aggregation. [GOC:add]"}
{"concept_id": "C2247704", "aliases": ["regulation of toll-like receptor signalling pathway", "regulation of TLR signaling pathway"], "types": ["T044"], "canonical_name": "regulation of toll-like receptor signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247705", "aliases": ["negative regulation of toll-like receptor signalling pathway", "negative regulation of TLR signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247706", "aliases": ["positive regulation of toll-like receptor signalling pathway", "positive regulation of TLR signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247707", "aliases": ["regulation ofMyD88-dependent toll-like receptor signalling pathway", "regulation ofMyD88-dependent TLR signaling pathway"], "types": ["T039"], "canonical_name": "regulation of MyD88-dependent toll-like receptor signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247708", "aliases": ["negative regulation of MyD88-dependent toll-like receptor signalling pathway", "negative regulation of MyD88-dependent TLR signaling pathway"], "types": ["T039"], "canonical_name": "negative regulation of MyD88-dependent toll-like receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247709", "aliases": ["positive regulation of MyD88-dependent toll-like receptor signalling pathway", "positive regulation of MyD88-dependent TLR signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of MyD88-dependent toll-like receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247710", "aliases": ["regulation ofMyD88-independent TLR signaling pathway", "regulation ofMyD88-independent toll-like receptor signalling pathway"], "types": ["T039"], "canonical_name": "regulation of MyD88-independent toll-like receptor signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247711", "aliases": ["negative regulation of MyD88-independent toll-like receptor signalling pathway", "negative regulation of MyD88-independent TLR signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of MyD88-independent toll-like receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247712", "aliases": ["positive regulation of MyD88-independent toll-like receptor signalling pathway", "positive regulation of MyD88-independent toll-like receptor", "positive regulation of MyD88-independent TLR signaling pathway"], "types": ["T039"], "canonical_name": "positive regulation of MyD88-independent toll-like receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247713", "aliases": ["TLR1 signaling pathway", "toll-like receptor 1 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 1 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 1. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247714", "aliases": ["regulation of toll-like receptor 1 signalling pathway", "regulation of TLR1 signaling pathway"], "types": ["T039"], "canonical_name": "regulation of toll-like receptor 1 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 1 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247715", "aliases": ["negative regulation of TLR1 signaling pathway", "negative regulation of toll-like receptor 1 signalling pathway"], "types": ["T039"], "canonical_name": "negative regulation of toll-like receptor 1 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 1 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247716", "aliases": ["positive regulation of TLR1 signaling pathway", "positive regulation of toll-like receptor 1 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 1 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 1 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247717", "aliases": ["toll-like receptor 2 signalling pathway", "TLR2 signaling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 2 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 2. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247718", "aliases": ["regulation of toll-like receptor 2 signalling pathway", "regulation of TLR2 signaling pathway"], "types": ["T044"], "canonical_name": "regulation of toll-like receptor 2 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247719", "aliases": ["negative regulation of toll-like receptor 2 signalling pathway", "negative regulation of TLR2 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 2 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247720", "aliases": ["positive regulation of TLR2 signaling pathway", "positive regulation of toll-like receptor 2 signalling pathway"], "types": ["T039"], "canonical_name": "positive regulation of toll-like receptor 2 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247721", "aliases": ["TLR3 signaling pathway", "toll-like receptor 3 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 3 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 3. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247722", "aliases": ["regulation of TLR3 signaling pathway", "regulation of toll-like receptor 3 signalling pathway"], "types": ["T044"], "canonical_name": "regulation of toll-like receptor 3 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247723", "aliases": ["negative regulation of TLR3 signaling pathway", "negative regulation of toll-like receptor 3 signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 3 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247724", "aliases": ["positive regulation of toll-like receptor 3 signalling pathway", "positive regulation of TLR3 signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 3 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247725", "aliases": ["toll-like receptor 4 signalling pathway", "TLR4 signaling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 4 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 4. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247726", "aliases": ["regulation of TLR4 signaling pathway", "regulation of toll-like receptor 4 signalling pathway"], "types": ["T039"], "canonical_name": "regulation of toll-like receptor 4 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247727", "aliases": ["negative regulation of toll-like receptor 4 signalling pathway", "negative regulation of TLR4 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 4 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247728", "aliases": ["positive regulation of toll-like receptor 4 signalling pathway", "positive regulation of TLR4 signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 4 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247729", "aliases": ["TLR5 signaling pathway", "toll-like receptor 5 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 5 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 5. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247730", "aliases": ["regulation of toll-like receptor 5 signalling pathway", "regulation of TLR5 signaling pathway"], "types": ["T039"], "canonical_name": "regulation of toll-like receptor 5 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247731", "aliases": ["negative regulation of toll-like receptor 5 signalling pathway", "negative regulation of TLR5 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 5 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247732", "aliases": ["positive regulation of TLR5 signaling pathway", "positive regulation of toll-like receptor 5 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 5 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247733", "aliases": ["TLR6 signaling pathway", "toll-like receptor 6 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 6 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 6. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247734", "aliases": ["regulation of toll-like receptor 6 signalling pathway", "regulation of TLR6 signaling pathway"], "types": ["T039"], "canonical_name": "regulation of toll-like receptor 6 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 6 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247735", "aliases": ["negative regulation of TLR6 signaling pathway", "negative regulation of toll-like receptor 6 signalling pathway"], "types": ["T039"], "canonical_name": "negative regulation of toll-like receptor 6 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247736", "aliases": ["positive regulation of TLR6 signaling pathway", "positive regulation of toll-like receptor 6 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 6 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247737", "aliases": ["toll-like receptor 7 signalling pathway", "TLR7 signaling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 7 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 7. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247738", "aliases": ["regulation of toll-like receptor 7 signalling pathway", "regulation of TLR7 signaling pathway"], "types": ["T039"], "canonical_name": "regulation of toll-like receptor 7 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247739", "aliases": ["negative regulation of TLR7 signaling pathway", "negative regulation of toll-like receptor 7 signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 7 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247740", "aliases": ["positive regulation of TLR7 signaling pathway", "positive regulation of toll-like receptor 7 signalling pathway"], "types": ["T039"], "canonical_name": "positive regulation of toll-like receptor 7 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247741", "aliases": ["TLR8 signaling pathway", "toll-like receptor 8 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 8 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 8. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247742", "aliases": ["regulation of toll-like receptor 8 signalling pathway", "regulation of TLR8 signaling pathway"], "types": ["T044"], "canonical_name": "regulation of toll-like receptor 8 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 8 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247743", "aliases": ["negative regulation of TLR8 signaling pathway", "negative regulation of toll-like receptor 8 signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 8 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247744", "aliases": ["positive regulation of TLR8 signaling pathway", "positive regulation of toll-like receptor 8 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 8 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247745", "aliases": ["TLR9 signaling pathway", "toll-like receptor 9 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 9 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 9. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247746", "aliases": ["regulation of TLR9 signaling pathway", "regulation of toll-like receptor 9 signalling pathway"], "types": ["T039"], "canonical_name": "regulation of toll-like receptor 9 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247747", "aliases": ["negative regulation of toll-like receptor 9 signalling pathway", "negative regulation of TLR9 signaling pathway"], "types": ["T039"], "canonical_name": "negative regulation of toll-like receptor 9 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247748", "aliases": ["positive regulation of TLR9 signaling pathway", "positive regulation of toll-like receptor 9 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 9 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247749", "aliases": ["TLR10 signaling pathway", "toll-like receptor 10 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 10 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 10. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247750", "aliases": ["regulation of TLR10 signaling pathway", "regulation of toll-like receptor 10 signalling pathway"], "types": ["T044"], "canonical_name": "regulation of toll-like receptor 10 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 10 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247751", "aliases": ["negative regulation of TLR10 signaling pathway", "negative regulation of toll-like receptor 10 signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 10 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247752", "aliases": ["positive regulation of TLR10 signaling pathway", "positive regulation of toll-like receptor 10 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 10 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247753", "aliases": ["toll-like receptor 11 signalling pathway", "TLR11 signaling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 11 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 11. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247754", "aliases": ["regulation of TLR11 signaling pathway", "regulation of toll-like receptor 11 signalling pathway"], "types": ["T039"], "canonical_name": "regulation of toll-like receptor 11 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247755", "aliases": ["negative regulation of toll-like receptor 11 signalling pathway", "negative regulation of TLR11 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 11 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247756", "aliases": ["positive regulation of TLR11 signaling pathway", "positive regulation of toll-like receptor 11 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 11 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247757", "aliases": ["toll-like receptor 12 signalling pathway", "TLR12 signaling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 12 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 12. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247758", "aliases": ["regulation of TLR12 signaling pathway", "regulation of toll-like receptor 12 signalling pathway"], "types": ["T044"], "canonical_name": "regulation of toll-like receptor 12 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 12 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247759", "aliases": ["negative regulation of TLR12 signaling pathway", "negative regulation of toll-like receptor 12 signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 12 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247760", "aliases": ["positive regulation of TLR12 signaling pathway", "positive regulation of toll-like receptor 12 signalling pathway"], "types": ["T039"], "canonical_name": "positive regulation of toll-like receptor 12 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247761", "aliases": ["TLR13 signaling pathway", "toll-like receptor 13 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 13 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 13. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247762", "aliases": ["regulation of toll-like receptor 13 signalling pathway", "regulation of TLR13 signaling pathway"], "types": ["T044"], "canonical_name": "regulation of toll-like receptor 13 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of toll-like receptor 13 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247763", "aliases": ["negative regulation of toll-like receptor 13 signalling pathway", "negative regulation of TLR13 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 13 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247764", "aliases": ["positive regulation of TLR13 signaling pathway", "positive regulation of toll-like receptor 13 signalling pathway"], "types": ["T039"], "canonical_name": "positive regulation of toll-like receptor 13 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]"}
{"concept_id": "C2247765", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maintenance of mitotic sister chromatid cohesion", "definition": "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247766", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of maintenance of mitotic sister chromatid cohesion", "definition": "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247767", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of maintenance of mitotic sister chromatid cohesion", "definition": "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247768", "aliases": [], "types": ["T044"], "canonical_name": "apolipoprotein binding", "definition": "Binding to an apolipoprotein, the protein component of a lipoprotein complex. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2247769", "aliases": [], "types": ["T044"], "canonical_name": "apolipoprotein A-I binding", "definition": "Binding to apolipoprotein A-I. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2247771", "aliases": [], "types": ["T044"], "canonical_name": "apolipoprotein A-I receptor activity", "definition": "Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:BHF, GOC:rl, GOC:signaling, PMID:16443932]"}
{"concept_id": "C2247772", "aliases": ["VLDL binding", "very-low-density lipoprotein binding"], "types": ["T044"], "canonical_name": "very-low-density lipoprotein particle binding", "definition": "Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2247773", "aliases": [], "types": ["T044"], "canonical_name": "apolipoprotein receptor binding", "definition": "Binding to an apolipoprotein receptor. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2247774", "aliases": [], "types": ["T044"], "canonical_name": "apolipoprotein A-I receptor binding", "definition": "Binding to an apolipoprotein A-I receptor. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2247775", "aliases": ["D-galactonate metabolism"], "types": ["T044"], "canonical_name": "D-galactonate metabolic process", "definition": "The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid. [GOC:mah]"}
{"concept_id": "C2247776", "aliases": ["L-galactonate metabolism"], "types": ["T044"], "canonical_name": "L-galactonate metabolic process", "definition": "The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid. [GOC:mah]"}
{"concept_id": "C2247777", "aliases": ["D-galactonate breakdown", "D-galactonate catabolism", "D-galactonate degradation"], "types": ["T044"], "canonical_name": "D-galactonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid. [GOC:ai, GOC:mah]"}
{"concept_id": "C2247778", "aliases": ["L-galactonate catabolism", "L-galactonate breakdown", "L-galactonate degradation"], "types": ["T044"], "canonical_name": "L-galactonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid. [GOC:ai, GOC:mah]"}
{"concept_id": "C2247779", "aliases": ["glyceride transport"], "types": ["T043"], "canonical_name": "acylglycerol transport", "definition": "The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2247780", "aliases": ["triacylglycerol transport"], "types": ["T043"], "canonical_name": "triglyceride transport", "definition": "The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2247781", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to amino acid starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. [GOC:ecd]"}
{"concept_id": "C2247782", "aliases": ["protein kinase A activation"], "types": ["T043"], "canonical_name": "activation of protein kinase A activity", "definition": "Any process that initiates the activity of the inactive enzyme protein kinase A. [GOC:pde]"}
{"concept_id": "C2247784", "aliases": ["response to oleate"], "types": ["T043"], "canonical_name": "response to oleic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus. [GOC:lp]"}
{"concept_id": "C2247785", "aliases": [], "types": ["T044"], "canonical_name": "glycolipid-translocating activity"}
{"concept_id": "C2247786", "aliases": ["flippase activity", "flippase activity (exoplasmic to cytosolic leaftlet)"], "types": ["T044"], "canonical_name": "flippase activity", "definition": "Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:20043909, PMID:25284293, Wikipedia:Flippase]"}
{"concept_id": "C2247787", "aliases": [], "types": ["T043"], "canonical_name": "glycolipid translocation", "definition": "The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. [GOC:go_curators, PMID:11807558]"}
{"concept_id": "C2247788", "aliases": [], "types": ["T043"], "canonical_name": "flippase"}
{"concept_id": "C2247790", "aliases": ["intramembrane lipid transfer"], "types": ["T043"], "canonical_name": "lipid translocation", "definition": "The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. [GOC:mah]"}
{"concept_id": "C2247791", "aliases": ["beta-amyloid polypeptide formation from amyloid precursor protein", "beta-amyloid formation", "beta-amyloid polypeptide formation from APP"], "types": ["T044"], "canonical_name": "amyloid-beta formation", "definition": "The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP). [GOC:mah]"}
{"concept_id": "C2247792", "aliases": [], "types": ["T026"], "canonical_name": "enhanceosome", "definition": "A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation. [PMID:11250145, PMID:17574024]"}
{"concept_id": "C2247793", "aliases": [], "types": ["T044"], "canonical_name": "steroid acetylation", "definition": "The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:mah]"}
{"concept_id": "C2247794", "aliases": [], "types": ["T044"], "canonical_name": "steroid deacetylation", "definition": "The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:mah]"}
{"concept_id": "C2247795", "aliases": [], "types": ["T044"], "canonical_name": "sterol acetylation", "definition": "The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:rb, PMID:18034159]"}
{"concept_id": "C2247796", "aliases": [], "types": ["T044"], "canonical_name": "sterol deacetylation", "definition": "The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:rb, PMID:18034159]"}
{"concept_id": "C2247797", "aliases": [], "types": ["T044"], "canonical_name": "GTP-dependent protein kinase activity", "definition": "GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. [GOC:ecd, PMID:17200152]"}
{"concept_id": "C2247798", "aliases": [], "types": ["T044"], "canonical_name": "peptide N-acetyltransferase activity", "definition": "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. [GOC:mah]"}
{"concept_id": "C2247799", "aliases": ["quinolinate catabolism", "quinolinate degradation", "quinolinate breakdown"], "types": ["T044"], "canonical_name": "quinolinate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. [GOC:mah]"}
{"concept_id": "C2247800", "aliases": ["protein hexamer biosynthetic process", "protein hexamer formation", "protein hexamer assembly", "protein hexamer biosynthesis"], "types": ["T044"], "canonical_name": "protein hexamerization", "definition": "The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits. [GOC:ecd]"}
{"concept_id": "C2247801", "aliases": ["thiamin:proton symporter activity", "thiamin:hydrogen symporter activity", "thiamine:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "thiamine:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). [GOC:mah]"}
{"concept_id": "C2247802", "aliases": ["high-affinity thiamin:proton symporter activity", "high affinity thiamin:hydrogen symporter activity", "high-affinity thiamine:hydrogen symporter activity", "high-affinity thiamin:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "high-affinity thiamine:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mah]"}
{"concept_id": "C2247803", "aliases": ["ascospore wall chitin synthesis", "ascospore wall chitin anabolism", "ascospore wall chitin formation", "ascospore wall chitin biosynthesis"], "types": ["T044"], "canonical_name": "ascospore wall chitin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247804", "aliases": ["ascospore wall chitin metabolism"], "types": ["T044"], "canonical_name": "ascospore wall chitin metabolic process", "definition": "The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores. [GOC:mah, GOC:vw]"}
{"concept_id": "C2247805", "aliases": ["carbohydrate membrane transport", "transmembrane carbohydrate transport"], "types": ["T043"], "canonical_name": "carbohydrate transmembrane transport", "definition": "The process in which a carbohydrate is transported across a membrane. [GOC:mah]"}
{"concept_id": "C2247806", "aliases": ["ion membrane transport", "transmembrane ion transport"], "types": ["T043"], "canonical_name": "ion transmembrane transport", "definition": "A process in which an ion is transported across a membrane. [GOC:mah]"}
{"concept_id": "C2247807", "aliases": ["fungal-type cell wall chitin anabolism", "fungal-type cell wall chitin formation", "fungal-type cell wall chitin biosynthesis", "fungal-type cell wall chitin synthesis"], "types": ["T044"], "canonical_name": "fungal-type cell wall chitin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells. [GOC:mah]"}
{"concept_id": "C2247808", "aliases": ["regulation of cell wall chitin metabolism"], "types": ["T043"], "canonical_name": "regulation of cell wall chitin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall. [GOC:mah]"}
{"concept_id": "C2247809", "aliases": ["regulation of ascospore wall chitin formation", "regulation of ascospore wall chitin biosynthesis", "regulation of ascospore wall chitin anabolism", "regulation of ascospore wall chitin synthesis"], "types": ["T043"], "canonical_name": "regulation of ascospore wall chitin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin. [GOC:mah]"}
{"concept_id": "C2247810", "aliases": ["cellular response to zinc starvation", "cellular response to zinc ion limitation"], "types": ["T043"], "canonical_name": "cellular response to zinc ion starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions. [GOC:mah]"}
{"concept_id": "C2247814", "aliases": ["tRNA thiolation"], "types": ["T045"], "canonical_name": "tRNA thio-modification", "definition": "The addition a sulfur atom to a nucleotide in a tRNA molecule. [GOC:mcc, PMID:12549933, PMID:14722066]"}
{"concept_id": "C2247815", "aliases": ["monoethanolamine transmembrane transporter activity", "ethanolamine permease activity", "2-aminoethanol transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ethanolamine transmembrane transporter activity", "definition": "Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. [GOC:rn, PMID:3514579]"}
{"concept_id": "C2247816", "aliases": ["monoethanolamine transport", "2-aminoethanol transport"], "types": ["T043"], "canonical_name": "ethanolamine transport", "definition": "The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. [GOC:rn, PMID:3514579]"}
{"concept_id": "C2247817", "aliases": ["enkephalin formation", "peptide enkephalin formation", "peptide enkephalin processing"], "types": ["T044"], "canonical_name": "enkephalin processing", "definition": "The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide. [GOC:BHF, GOC:mah, GOC:rl, PMID:8262946]"}
{"concept_id": "C2247818", "aliases": ["IAPP processing", "islet amyloid peptide formation", "IAPP formation", "islet amyloid peptide processing"], "types": ["T044"], "canonical_name": "islet amyloid polypeptide processing", "definition": "The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP). [GOC:BHF, GOC:rl, PMID:15983213, PMID:8262946]"}
{"concept_id": "C2247819", "aliases": [], "types": ["T044"], "canonical_name": "islet amyloid polypeptide formation"}
{"concept_id": "C2247820", "aliases": ["ascospore wall chitin catabolism", "ascospore wall chitin breakdown", "ascospore wall chitin degradation"], "types": ["T044"], "canonical_name": "ascospore wall chitin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores. [GOC:mah]"}
{"concept_id": "C2247821", "aliases": ["regulation of cell wall chitin catabolism", "regulation of cell wall chitin degradation", "regulation of cell wall chitin breakdown"], "types": ["T040"], "canonical_name": "regulation of cell wall chitin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin. [GOC:mah]"}
{"concept_id": "C2247822", "aliases": ["regulation of ascospore wall chitin breakdown", "regulation of ascospore wall chitin degradation", "regulation of ascospore wall chitin catabolism"], "types": ["T044"], "canonical_name": "regulation of ascospore wall chitin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of ascospore wall chitin. [GOC:mah]"}
{"concept_id": "C2247823", "aliases": ["PKA catalytic subunit binding"], "types": ["T044"], "canonical_name": "protein kinase A catalytic subunit binding", "definition": "Binding to one or both of the catalytic subunits of protein kinase A. [GOC:mah]"}
{"concept_id": "C2247824", "aliases": ["PKA regulatory subunit binding"], "types": ["T044"], "canonical_name": "protein kinase A regulatory subunit binding", "definition": "Binding to one or both of the regulatory subunits of protein kinase A. [GOC:mah]"}
{"concept_id": "C2247825", "aliases": [], "types": ["T043"], "canonical_name": "macrophage fusion", "definition": "The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell. [GOC:sl]"}
{"concept_id": "C2247826", "aliases": [], "types": ["T043"], "canonical_name": "regulation of macrophage fusion", "definition": "Any process that modulates the frequency, rate or extent of macrophage fusion. [GOC:mah]"}
{"concept_id": "C2247827", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of macrophage fusion", "definition": "Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion. [GOC:mah]"}
{"concept_id": "C2247828", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of macrophage fusion", "definition": "Any process that activates or increases the frequency, rate or extent of macrophage fusion. [GOC:mah]"}
{"concept_id": "C2247829", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of syncytium formation by plasma membrane fusion", "definition": "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:mah]"}
{"concept_id": "C2247830", "aliases": ["regulation of RNA elongation from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of transcription elongation from RNA polymerase II promoter", "definition": "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C2247832", "aliases": ["negative regulation of RNA elongation from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of transcription elongation from RNA polymerase II promoter", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C2247834", "aliases": ["mitochondrial RNA polymerase holoenzyme complex location", "mitochondrial RNA polymerase holoenzyme complex", "mitochondrial DNA-directed RNA polymerase complex location"], "types": ["T026"], "canonical_name": "mitochondrial DNA-directed RNA polymerase complex", "definition": "A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form. [GOC:krc, GOC:mah, PMID:7929382]"}
{"concept_id": "C2247835", "aliases": ["mitochondrial RNA polymerase complex location"], "types": ["T026"], "canonical_name": "mitochondrial RNA polymerase complex"}
{"concept_id": "C2247837", "aliases": ["mitochondrial sequence-specific DNA-binding transcription factor activity", "mitochondrial sequence-specific DNA binding transcription factor activity", "mitochondrial transcription initiation factor activity", "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity", "mitochondrial polymerase transcription factor activity", "transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding", "mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity", "sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity", "transcription factor activity, mitochondrial proximal promoter sequence-specific binding", "transcription factor activity, mitochondrial RNA polymerase core promoter sequence-specific DNA binding", "mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding", "mitochondrial RNA polymerase binding promoter specificity activity"], "types": ["T045"], "canonical_name": "mitochondrial transcription factor activity", "definition": "Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase. [GOC:txnOH-2018, PMID:18391175]"}
{"concept_id": "C2247838", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA splicing", "definition": "The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA. [GOC:mah]"}
{"concept_id": "C2247839", "aliases": ["regulation of amide metabolism"], "types": ["T040"], "canonical_name": "regulation of cellular amide metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. [GOC:mah]"}
{"concept_id": "C2247840", "aliases": ["negative regulation of amide metabolism"], "types": ["T040"], "canonical_name": "negative regulation of cellular amide metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. [GOC:mah]"}
{"concept_id": "C2247841", "aliases": ["positive regulation of amide metabolism"], "types": ["T044"], "canonical_name": "positive regulation of cellular amide metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. [GOC:mah]"}
{"concept_id": "C2247842", "aliases": ["regulation of amide degradation", "regulation of amide catabolism", "regulation of amide breakdown"], "types": ["T040"], "canonical_name": "regulation of cellular amide catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. [GOC:mah]"}
{"concept_id": "C2247843", "aliases": ["negative regulation of amide catabolism", "negative regulation of amide breakdown"], "types": ["T044"], "canonical_name": "negative regulation of cellular amide catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. [GOC:mah]"}
{"concept_id": "C2247844", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of amide degradation"}
{"concept_id": "C2247845", "aliases": ["positive regulation of amide catabolism", "positive regulation of amide breakdown"], "types": ["T040"], "canonical_name": "positive regulation of cellular amide catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. [GOC:mah]"}
{"concept_id": "C2247846", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of amide degradation"}
{"concept_id": "C2247847", "aliases": ["regulation of urea catabolism", "regulation of urea degradation", "regulation of urea breakdown"], "types": ["T040"], "canonical_name": "regulation of urea catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea. [GOC:mah]"}
{"concept_id": "C2247848", "aliases": ["regulation of urea metabolism"], "types": ["T040"], "canonical_name": "regulation of urea metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea. [GOC:mah]"}
{"concept_id": "C2247849", "aliases": ["chlorophyllide b reductase activity", "Chl b reductase activity", "chlorophyll b reductase activity"], "types": ["T044"], "canonical_name": "chlorophyll(ide) b reductase activity", "definition": "Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+. [EC:1.1.1.294, MetaCyc:RXN-7678]"}
{"concept_id": "C2247851", "aliases": [], "types": ["T043"], "canonical_name": "nicotinamide riboside transport", "definition": "The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:se]"}
{"concept_id": "C2247852", "aliases": ["downregulation of Rho GTPase activity", "negative regulation of Rho GTPase activity", "down-regulation of Rho GTPase activity"], "types": ["T044"], "canonical_name": "down regulation of Rho GTPase activity"}
{"concept_id": "C2247853", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Rho GTPase activity"}
{"concept_id": "C2247854", "aliases": ["downregulation of GTPase activity", "negative regulation of guanosinetriphosphatase activity", "down-regulation of GTPase activity", "down regulation of GTPase activity"], "types": ["T044"], "canonical_name": "negative regulation of GTPase activity", "definition": "Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649]"}
{"concept_id": "C2247855", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of GTPase activity"}
{"concept_id": "C2247856", "aliases": ["negative regulation of Ras GTPase activity", "down-regulation of Ras GTPase activity", "downregulation of Ras GTPase activity"], "types": ["T044"], "canonical_name": "down regulation of Ras GTPase activity"}
{"concept_id": "C2247857", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Ras GTPase activity"}
{"concept_id": "C2247859", "aliases": ["autophagy in response to ER stress", "autophagy in response to endoplasmic reticulum overload"], "types": ["T043"], "canonical_name": "positive regulation of autophagy in response to ER overload", "definition": "The process in which the accumulation of misfolded proteins in the endoplasmic reticulum triggers a response that positively regulates autophagy. [GOC:mah]"}
{"concept_id": "C2247860", "aliases": ["isopentenyl adenine metabolism", "isopentenyladenine metabolic process"], "types": ["T044"], "canonical_name": "isopentenyl adenine metabolic process", "definition": "The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine. [GOC:mah, PMID:18216168]"}
{"concept_id": "C2247861", "aliases": ["isopentenyl adenine formation", "isopentenyl adenine anabolism", "isopentenyl adenine biosynthesis", "isopentenyl adenine synthesis", "isopentenyladenine biosynthetic process"], "types": ["T044"], "canonical_name": "isopentenyl adenine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine. [GOC:mah, PMID:18216168]"}
{"concept_id": "C2247862", "aliases": ["isopentenyladenine catabolic process", "isopentenyl adenine catabolism", "isopentenyl adenine breakdown", "isopentenyl adenine degradation"], "types": ["T044"], "canonical_name": "isopentenyl adenine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine. [GOC:mah, PMID:18216168]"}
{"concept_id": "C2247863", "aliases": ["discadenine metabolism"], "types": ["T044"], "canonical_name": "discadenine metabolic process", "definition": "The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid. [GOC:mah]"}
{"concept_id": "C2247864", "aliases": ["discadenine synthesis", "discadenine anabolism", "discadenine formation", "discadenine biosynthesis"], "types": ["T044"], "canonical_name": "discadenine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid. [GOC:mah]"}
{"concept_id": "C2247865", "aliases": ["discadenine catabolism", "discadenine degradation", "discadenine breakdown"], "types": ["T044"], "canonical_name": "discadenine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid. [GOC:mah]"}
{"concept_id": "C2247866", "aliases": ["cytoplasm to vacuole targeting complex location", "cytoplasm-to-vacuole targeting complex location", "cytoplasm-to-vacuole targeting complex", "cytoplasm to vacuole targeting complex", "Cvt complex location"], "types": ["T026"], "canonical_name": "Cvt complex", "definition": "A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p. [GOC:rb, PMID:15659643]"}
{"concept_id": "C2247868", "aliases": ["phosphatidylinositol 3-kinase complex I location", "PtdIns-3-kinase complex I", "PtdIns-3-kinase complex I location"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex I"}
{"concept_id": "C2247869", "aliases": ["PtdIns-3-kinase complex II location", "phosphatidylinositol 3-kinase complex II location", "PtdIns-3-kinase complex II"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex II"}
{"concept_id": "C2247871", "aliases": ["Atg12-Atg5-Atg16 complex location"], "types": ["T026"], "canonical_name": "Atg12-Atg5-Atg16 complex", "definition": "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p. [GOC:rb, PMID:17986448]"}
{"concept_id": "C2247872", "aliases": ["kynurenic acid metabolism", "4-hydroxyquinoline-2-carboxylic acid metabolic process"], "types": ["T044"], "canonical_name": "kynurenic acid metabolic process", "definition": "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid. [GOC:mah]"}
{"concept_id": "C2247873", "aliases": ["kynurenic acid biosynthesis", "4-hydroxyquinoline-2-carboxylic acid biosynthetic process", "kynurenic acid synthesis", "kynurenic acid anabolism"], "types": ["T044"], "canonical_name": "kynurenic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid. [GOC:mah]"}
{"concept_id": "C2247874", "aliases": [], "types": ["T044"], "canonical_name": "kynurenic acid formation"}
{"concept_id": "C2247875", "aliases": ["ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity"], "types": ["T044"], "canonical_name": "ent-cassa-12,15-diene synthase activity", "definition": "Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate. [EC:4.2.3.28, RHEA:25532]"}
{"concept_id": "C2247876", "aliases": ["9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity"], "types": ["T044"], "canonical_name": "stemar-13-ene synthase activity", "definition": "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate. [RHEA:25552]"}
{"concept_id": "C2247877", "aliases": ["9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity"], "types": ["T044"], "canonical_name": "syn-pimara-7,15-diene synthase activity", "definition": "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate. [RHEA:25560]"}
{"concept_id": "C2247878", "aliases": ["ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity"], "types": ["T044"], "canonical_name": "ent-sandaracopimaradiene synthase activity", "definition": "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate. [RHEA:25536]"}
{"concept_id": "C2247879", "aliases": ["ent-pimaradiene synthase activity"], "types": ["T044"], "canonical_name": "ent-pimaradiene synthase activity"}
{"concept_id": "C2247880", "aliases": [], "types": ["T044"], "canonical_name": "ent-isokaurene synthase activity", "definition": "Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate. [PMID:17141283]"}
{"concept_id": "C2247881", "aliases": ["ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] activity"], "types": ["T044"], "canonical_name": "ent-pimara-8(14),15-diene synthase activity", "definition": "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate. [RHEA:25540]"}
{"concept_id": "C2247882", "aliases": ["9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] activity", "exo-stemodene synthase activity", "syn-stemodene synthase activity", "stemod-13(17)-ene synthase activity", "stemodene synthase activity"], "types": ["T044"], "canonical_name": "syn-stemod-13(17)-ene synthase activity", "definition": "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate. [RHEA:25556]"}
{"concept_id": "C2247883", "aliases": ["response to monosaccharide stimulus"], "types": ["T043"], "canonical_name": "response to monosaccharide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus. [GOC:mah]"}
{"concept_id": "C2247884", "aliases": ["response to disaccharide stimulus"], "types": ["T043"], "canonical_name": "response to disaccharide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus. [GOC:sart]"}
{"concept_id": "C2247885", "aliases": ["response to maltose stimulus"], "types": ["T043"], "canonical_name": "response to maltose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus. [GOC:sart]"}
{"concept_id": "C2247886", "aliases": [], "types": ["T043"], "canonical_name": "detection of monosaccharide stimulus", "definition": "The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal. [GOC:mah]"}
{"concept_id": "C2247887", "aliases": [], "types": ["T043"], "canonical_name": "perception of monosaccharide stimulus"}
{"concept_id": "C2247888", "aliases": [], "types": ["T043"], "canonical_name": "detection of disaccharide stimulus", "definition": "The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal. [GOC:sart]"}
{"concept_id": "C2247889", "aliases": [], "types": ["T043"], "canonical_name": "perception of disaccharide stimulus"}
{"concept_id": "C2247890", "aliases": [], "types": ["T043"], "canonical_name": "detection of maltose stimulus", "definition": "The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal. [GOC:sart]"}
{"concept_id": "C2247891", "aliases": [], "types": ["T043"], "canonical_name": "perception of maltose stimulus"}
{"concept_id": "C2247892", "aliases": [], "types": ["T044"], "canonical_name": "canonical holin activity", "definition": "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell. [GOC:jh2, GOC:mah, PMID:1406491, PMID:25157079]"}
{"concept_id": "C2247893", "aliases": [], "types": ["T044"], "canonical_name": "pinholin activity", "definition": "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting ion channel activity indirectly allows endolysin (murein hydrolyases) to access their cell wall substrate by collapsing the proton motive force (PMF) across the membrane, allowing the endolysin to fold to an active form and hydrolyze bonds in the peptidoglycan cell wall. [GOC:jh2, GOC:mah, PMID:1406491, PMID:25157079]"}
{"concept_id": "C2247894", "aliases": ["meiotic sporulation", "meiotic spore formation", "sexual spore formation"], "types": ["T043"], "canonical_name": "sexual sporulation", "definition": "The formation of spores derived from the products of meiosis. [GOC:mah]"}
{"concept_id": "C2247895", "aliases": ["sexual spore wall formation"], "types": ["T043"], "canonical_name": "sexual spore wall assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis. [GOC:mah]"}
{"concept_id": "C2247896", "aliases": [], "types": ["T043"], "canonical_name": "basidiospore formation", "definition": "The process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium. [GOC:di, GOC:ds, GOC:mah, GOC:mcc, http://www.gsbs.utmb.edu/microbook/ch073.htm, http://www.ilmyco.gen.chicago.il.us/Terms/basid133.html]"}
{"concept_id": "C2247897", "aliases": [], "types": ["T043"], "canonical_name": "zygospore formation", "definition": "The process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away. [GOC:ds, GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/zygos581.html]"}
{"concept_id": "C2247898", "aliases": [], "types": ["T043"], "canonical_name": "oidium formation", "definition": "The process in which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus. [GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/oidiu163.html]"}
{"concept_id": "C2247899", "aliases": ["arthroconidium formation"], "types": ["T043"], "canonical_name": "arthrospore formation", "definition": "The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation. [GOC:mah]"}
{"concept_id": "C2247900", "aliases": ["blastoconidium formation"], "types": ["T043"], "canonical_name": "reproductive blastospore formation", "definition": "The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota. [GOC:mah, https://en.wikipedia.org/wiki/Blastospore]"}
{"concept_id": "C2247901", "aliases": [], "types": ["T043"], "canonical_name": "sporangiospore formation", "definition": "The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. [GOC:ds, GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_n_z.shtml]"}
{"concept_id": "C2247902", "aliases": [], "types": ["T043"], "canonical_name": "endospore formation", "definition": "The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions. [GOC:ds, GOC:mah, ISBN:0470090278]"}
{"concept_id": "C2247903", "aliases": [], "types": ["T043"], "canonical_name": "akinete formation", "definition": "The process in which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria. [GOC:ds, GOC:mah, http://www.msu.edu/course/bot/423/algalglossary.htm#Reproductive, PMID:11948167]"}
{"concept_id": "C2247904", "aliases": [], "types": ["T043"], "canonical_name": "myxospore formation", "definition": "The process in which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, dessication, and UV than vegetative myxobacteria. [GOC:ds, ISBN:0122268008]"}
{"concept_id": "C2247905", "aliases": [], "types": ["T043"], "canonical_name": "actinomycete-type spore formation", "definition": "The process in which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales. [GOC:ds, ISBN:0122268008]"}
{"concept_id": "C2247906", "aliases": ["regulation of mitotic spore formation", "regulation of asexual spore formation", "regulation of mitotic sporulation"], "types": ["T043"], "canonical_name": "regulation of asexual sporulation", "definition": "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis. [GOC:mah]"}
{"concept_id": "C2247907", "aliases": ["regulation of meiotic sporulation", "regulation of meiotic spore formation", "regulation of sexual spore formation"], "types": ["T043"], "canonical_name": "regulation of sexual sporulation", "definition": "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae. [GOC:mah]"}
{"concept_id": "C2247908", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ascospore formation", "definition": "Any process that modulates the frequency, rate or extent of ascospore formation. An example of this process is found in Saccharomyces cerevisiae. [GOC:mah]"}
{"concept_id": "C2247909", "aliases": ["primary alcohol metabolism", "monohydric alcohol metabolic process"], "types": ["T044"], "canonical_name": "primary alcohol metabolic process", "definition": "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. [GOC:mah]"}
{"concept_id": "C2247910", "aliases": ["primary alcohol anabolism", "monohydric alcohol biosynthetic process", "primary alcohol biosynthesis", "primary alcohol synthesis", "primary alcohol formation"], "types": ["T044"], "canonical_name": "primary alcohol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. [GOC:mah]"}
{"concept_id": "C2247911", "aliases": ["primary alcohol catabolism", "primary alcohol breakdown", "primary alcohol degradation", "monohydric alcohol catabolic process"], "types": ["T044"], "canonical_name": "primary alcohol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. [GOC:mah]"}
{"concept_id": "C2247912", "aliases": ["branched actin filament nucleation", "actin filament branch nucleation"], "types": ["T044"], "canonical_name": "Arp2/3 complex-mediated actin nucleation", "definition": "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. [GOC:mah, PMID:16959963, PMID:18640983]"}
{"concept_id": "C2247913", "aliases": [], "types": ["T040"], "canonical_name": "regulation of Arp2/3 complex-mediated actin nucleation", "definition": "Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. [GOC:mah]"}
{"concept_id": "C2247914", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of Arp2/3 complex-mediated actin nucleation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. [GOC:mah, PMID:16959963]"}
{"concept_id": "C2247915", "aliases": [], "types": ["T044"], "canonical_name": "nicotinic acid riboside kinase activity", "definition": "Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide. [PMID:17914902]"}
{"concept_id": "C2247916", "aliases": ["acyl-coenzymeA:alcohol O-acyltransferase activity", "acyl-CoA:alcohol O-acyltransferase activity", "alcohol acyltransferase activity"], "types": ["T044"], "canonical_name": "alcohol O-acyltransferase activity", "definition": "Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule. [GOC:mah]"}
{"concept_id": "C2247917", "aliases": [], "types": ["T044"], "canonical_name": "acyl-CoA:ethanol O-acyltransferase"}
{"concept_id": "C2247918", "aliases": ["AEATase activity"], "types": ["T044"], "canonical_name": "acyl-coenzymeA:ethanol O-acyltransferase activity"}
{"concept_id": "C2247920", "aliases": [], "types": ["T044"], "canonical_name": "alcohol O-butanoyltransferase activity", "definition": "Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester. [GOC:mah, PMID:16361250]"}
{"concept_id": "C2247921", "aliases": [], "types": ["T044"], "canonical_name": "alcohol O-hexanoyltransferase activity", "definition": "Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester. [GOC:mah, PMID:16361250]"}
{"concept_id": "C2247922", "aliases": [], "types": ["T044"], "canonical_name": "alcohol O-octanoyltransferase activity", "definition": "Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester. [GOC:mah, PMID:16361250]"}
{"concept_id": "C2247923", "aliases": [], "types": ["T044"], "canonical_name": "alcohol O-decanoyltransferase activity", "definition": "Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester. [GOC:mah, PMID:16361250]"}
{"concept_id": "C2247924", "aliases": [], "types": ["T044"], "canonical_name": "O-butanoyltransferase activity", "definition": "Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule. [GOC:mah]"}
{"concept_id": "C2247925", "aliases": [], "types": ["T044"], "canonical_name": "O-hexanoyltransferase activity", "definition": "Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule. [GOC:mah]"}
{"concept_id": "C2247926", "aliases": [], "types": ["T044"], "canonical_name": "O-decanoyltransferase activity", "definition": "Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule. [GOC:mah]"}
{"concept_id": "C2247927", "aliases": [], "types": ["T044"], "canonical_name": "butanoyltransferase activity", "definition": "Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule. [GOC:mah]"}
{"concept_id": "C2247928", "aliases": [], "types": ["T044"], "canonical_name": "hexanoyltransferase activity", "definition": "Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule. [GOC:mah]"}
{"concept_id": "C2247929", "aliases": [], "types": ["T044"], "canonical_name": "decanoyltransferase activity", "definition": "Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule. [GOC:mah]"}
{"concept_id": "C2247930", "aliases": [], "types": ["T043"], "canonical_name": "cell junction assembly", "definition": "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. [GOC:mah]"}
{"concept_id": "C2247931", "aliases": ["cell junction organisation", "cell junction assembly and maintenance"], "types": ["T043"], "canonical_name": "cell junction organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C2247932", "aliases": [], "types": ["T043"], "canonical_name": "cell junction maintenance", "definition": "The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C2247933", "aliases": ["adherens junction organisation"], "types": ["T043"], "canonical_name": "adherens junction organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C2247934", "aliases": ["adherens junction formation"], "types": ["T043"], "canonical_name": "adherens junction assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, GOC:mah]"}
{"concept_id": "C2247935", "aliases": [], "types": ["T043"], "canonical_name": "adherens junction maintenance", "definition": "The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, GOC:mah]"}
{"concept_id": "C2247936", "aliases": ["DNA-gyrase activity"], "types": ["T044"], "canonical_name": "DNA gyrase activity"}
{"concept_id": "C2247937", "aliases": [], "types": ["T045"], "canonical_name": "misfolded RNA binding", "definition": "Binding to an RNA molecule that has assumed an incorrect conformation. [GOC:mah, PMID:10393192]"}
{"concept_id": "C2247938", "aliases": ["RNA chaperone"], "types": ["T045"], "canonical_name": "RNA chaperone"}
{"concept_id": "C2247939", "aliases": [], "types": ["T044"], "canonical_name": "short-chain carboxylesterase activity", "definition": "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. [GOC:jp]"}
{"concept_id": "C2247940", "aliases": [], "types": ["T044"], "canonical_name": "butyrate esterase activity"}
{"concept_id": "C2247941", "aliases": [], "types": ["T044"], "canonical_name": "butyryl esterase activity"}
{"concept_id": "C2247942", "aliases": [], "types": ["T044"], "canonical_name": "methylbutyrase activity"}
{"concept_id": "C2247943", "aliases": [], "types": ["T044"], "canonical_name": "methylbutyrate esterase activity"}
{"concept_id": "C2247944", "aliases": [], "types": ["T044"], "canonical_name": "monobutyrase activity"}
{"concept_id": "C2247945", "aliases": [], "types": ["T044"], "canonical_name": "propionyl esterase activity"}
{"concept_id": "C2247946", "aliases": [], "types": ["T044"], "canonical_name": "short-chain esterase activity"}
{"concept_id": "C2247948", "aliases": ["response to type I IFN"], "types": ["T043"], "canonical_name": "response to type I interferon", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]"}
{"concept_id": "C2247949", "aliases": ["response to type II interferon", "response to immune interferon", "response to gamma-interferon", "response to type II IFN"], "types": ["T043"], "canonical_name": "response to interferon-gamma", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. [GOC:add, ISBN:0126896631, PMID:15546383]"}
{"concept_id": "C2247950", "aliases": ["response to interferon-lambda", "response to type III IFN"], "types": ["T043"], "canonical_name": "response to type III interferon", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]"}
{"concept_id": "C2247951", "aliases": ["type III IFN production"], "types": ["T040"], "canonical_name": "type III interferon production", "definition": "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]"}
{"concept_id": "C2247952", "aliases": ["regulation of type III IFN production"], "types": ["T040"], "canonical_name": "regulation of type III interferon production", "definition": "Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]"}
{"concept_id": "C2247953", "aliases": ["down-regulation of type III interferon production", "downregulation of type III interferon production", "negative regulation of type III IFN production", "down regulation of type III interferon production"], "types": ["T040"], "canonical_name": "negative regulation of type III interferon production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]"}
{"concept_id": "C2247954", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of type III interferon production"}
{"concept_id": "C2247955", "aliases": ["upregulation of type III interferon production", "up-regulation of type III interferon production", "up regulation of type III interferon production", "positive regulation of type III IFN production"], "types": ["T040"], "canonical_name": "positive regulation of type III interferon production", "definition": "Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]"}
{"concept_id": "C2247956", "aliases": [], "types": ["T040"], "canonical_name": "activation of type III interferon production"}
{"concept_id": "C2247957", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of type III interferon production"}
{"concept_id": "C2247958", "aliases": ["interferon-lambda binding"], "types": ["T044"], "canonical_name": "type III interferon binding", "definition": "Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]"}
{"concept_id": "C2247959", "aliases": ["interferon-lambda receptor activity"], "types": ["T044"], "canonical_name": "type III interferon receptor activity", "definition": "Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far. [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16734557]"}
{"concept_id": "C2247960", "aliases": ["apoptosis of glia", "programmed cell death, glia", "glia apoptosis", "programmed cell death of glial cells by apoptosis", "programmed cell death of glia by apoptosis", "glia programmed cell death by apoptosis", "apoptosis of glial cells", "glial cell programmed cell death by apoptosis", "glial cell apoptosis", "programmed cell death, glial cells"], "types": ["T043"], "canonical_name": "glial cell apoptotic process", "definition": "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. [CL:0000125, GOC:mtg_apoptosis, GOC:sart]"}
{"concept_id": "C2247961", "aliases": ["regulation of glial cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of glial cell apoptotic process", "definition": "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. [GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C2247962", "aliases": ["down regulation of glial cell apoptosis", "down-regulation of glial cell apoptosis", "negative regulation of glial cell apoptosis", "downregulation of glial cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of glial cell apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. [GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C2247963", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glial cell apoptosis"}
{"concept_id": "C2247965", "aliases": [], "types": ["T043"], "canonical_name": "activation of glial cell apoptosis"}
{"concept_id": "C2247966", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of glial cell apoptosis"}
{"concept_id": "C2247967", "aliases": [], "types": ["T045"], "canonical_name": "RNA pyrophosphohydrolase activity", "definition": "Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end. [GOC:jh2, PMID:17612492, PMID:18202662]"}
{"concept_id": "C2247969", "aliases": ["NAD salvage pathway"], "types": ["T044"], "canonical_name": "NAD salvage", "definition": "Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam). [GOC:mah, PMID:12648681, PMID:27374990]"}
{"concept_id": "C2247970", "aliases": ["NR salvage pathway", "nicotinamide riboside salvage pathway"], "types": ["T044"], "canonical_name": "NAD biosynthesis via nicotinamide riboside salvage pathway", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside. [PMID:17482543]"}
{"concept_id": "C2247971", "aliases": [], "types": ["T040"], "canonical_name": "dorsal trunk growth, open tracheal system", "definition": "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C2247972", "aliases": ["ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity", "phosphatidylinositol-4-phosphate 3-kinase activity"], "types": ["T044"], "canonical_name": "1-phosphatidylinositol-4-phosphate 3-kinase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). [EC:2.7.1.154, RHEA:18373]"}
{"concept_id": "C2247973", "aliases": [], "types": ["T044"], "canonical_name": "C2-domain-containing phosphoinositide 3-kinase activity"}
{"concept_id": "C2247974", "aliases": [], "types": ["T044"], "canonical_name": "type II phosphoinositide 3-kinase activity"}
{"concept_id": "C2247975", "aliases": [], "types": ["T046"], "canonical_name": "activation of melanization defense response"}
{"concept_id": "C2247976", "aliases": [], "types": ["T046"], "canonical_name": "stimulation of melanization defense response"}
{"concept_id": "C2247979", "aliases": [], "types": ["T046"], "canonical_name": "inhibition of melanization defense response"}
{"concept_id": "C2247981", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of Rac protein signal transduction"}
{"concept_id": "C2247982", "aliases": [], "types": ["T044"], "canonical_name": "activation of Rac protein signal transduction"}
{"concept_id": "C2247983", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of Rac protein signal transduction"}
{"concept_id": "C2247986", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Rho protein signal transduction"}
{"concept_id": "C2247987", "aliases": [], "types": ["T040"], "canonical_name": "activation of Rho protein signal transduction"}
{"concept_id": "C2247988", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of Rho protein signal transduction"}
{"concept_id": "C2247990", "aliases": ["heart cell differentiation", "cardiac cell differentiation"], "types": ["T043"], "canonical_name": "cardiocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. [GOC:bf]"}
{"concept_id": "C2247992", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of nuclear mRNA splicing via U2-type spliceosome"}
{"concept_id": "C2247993", "aliases": [], "types": ["T045"], "canonical_name": "activation of nuclear mRNA splicing via U2-type spliceosome"}
{"concept_id": "C2247994", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of nuclear mRNA splicing via U2-type spliceosome"}
{"concept_id": "C2247996", "aliases": ["vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control"], "types": ["T044"], "canonical_name": "vasoconstriction by vasopressin involved in systemic arterial blood pressure control", "definition": "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream. [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]"}
{"concept_id": "C2247997", "aliases": [], "types": ["T040"], "canonical_name": "vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure", "definition": "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. [GOC:dph, GOC:mtg_cardio]"}
{"concept_id": "C2247998", "aliases": [], "types": ["T040"], "canonical_name": "vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure", "definition": "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system. [GOC:mtg_cardio, ISBN:0721643949]"}
{"concept_id": "C2247999", "aliases": ["atrial low pressure baroreceptor regulation of blood pressure", "atrial baroreceptor regulation of systemic arterial blood pressure"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by atrial baroreceptor feedback", "definition": "A process that controls blood pressure by sensing the amount of stretch occurring in the atria. [GOC:dph, GOC:tb]"}
{"concept_id": "C2248000", "aliases": ["renin-angiotensin regulation of blood volume"], "types": ["T039"], "canonical_name": "regulation of blood volume by renin-angiotensin", "definition": "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]"}
{"concept_id": "C2248001", "aliases": ["aldosterone mediated regulation of blood volume", "renal regulation of blood volume by aldosterone"], "types": ["T039"], "canonical_name": "regulation of blood volume by renal aldosterone", "definition": "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume. [GOC:dph, GOC:tb, ISBN:0721643949]"}
{"concept_id": "C2248002", "aliases": ["vasodilation by angiotensin involved in regulation of systemic arterial blood pressure"], "types": ["T044"], "canonical_name": "angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure", "definition": "The process that increases the diameter of a blood vessel via the renin-angiotensin system. [GOC:pr, ISBN:0323031951, PMID:10425188]"}
{"concept_id": "C2248004", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-glutamate transport"}
{"concept_id": "C2248005", "aliases": [], "types": ["T040"], "canonical_name": "activation of L-glutamate transport"}
{"concept_id": "C2248006", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of L-glutamate transport"}
{"concept_id": "C2248008", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuroblast proliferation"}
{"concept_id": "C2248009", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neuroblast proliferation"}
{"concept_id": "C2248011", "aliases": [], "types": ["T043"], "canonical_name": "activation of mesenchymal cell proliferation"}
{"concept_id": "C2248012", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mesenchymal cell proliferation"}
{"concept_id": "C2248014", "aliases": [], "types": ["T042"], "canonical_name": "somitomeric trunk muscle development", "definition": "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus. [GOC:dph, PMID:16638982]"}
{"concept_id": "C2248016", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of receptor internalization"}
{"concept_id": "C2248017", "aliases": [], "types": ["T043"], "canonical_name": "activation of receptor internalization"}
{"concept_id": "C2248018", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of receptor internalization"}
{"concept_id": "C2248020", "aliases": [], "types": ["T026"], "definition": "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. [PMID:12837608, PMID:15890982]", "canonical_name": "podosome"}
{"concept_id": "C2248021", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)", "definition": "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. [GOC:curators]"}
{"concept_id": "C2248022", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)", "definition": "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. [GOC:curators]"}
{"concept_id": "C2248023", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)", "definition": "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. [GOC:curators]"}
{"concept_id": "C2248024", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)", "definition": "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. [GOC:curators]"}
{"concept_id": "C2248025", "aliases": [], "types": ["T045"], "canonical_name": "generation of mature 3'-end of 5S rRNA generated by RNA polymerase III", "definition": "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end. [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357]"}
{"concept_id": "C2248026", "aliases": [], "types": ["T045"], "canonical_name": "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)", "definition": "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2248027", "aliases": [], "types": ["T045"], "canonical_name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)", "definition": "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2248028", "aliases": [], "types": ["T045"], "canonical_name": "cotranscriptional mitochondrial rRNA nucleotide insertion", "definition": "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis. [GOC:curators, ISBN:1555811337, PMID:8306965]"}
{"concept_id": "C2248029", "aliases": ["BRCA2-BRAF35 complex location"], "types": ["T026"], "canonical_name": "BRCA2-BRAF35 complex", "definition": "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis. [GOC:hjd, PMID:11207365]"}
{"concept_id": "C2248030", "aliases": ["interleukin-33 receptor binding", "IL-33"], "types": ["T044"], "definition": "Binding to an interleukin-33 receptor. [GOC:hjd]", "canonical_name": "interleukin-33 receptor ligand"}
{"concept_id": "C2248031", "aliases": ["IL-33 binding"], "types": ["T044"], "canonical_name": "interleukin-33 binding", "definition": "Binding to interleukin-33. [GOC:hjd]"}
{"concept_id": "C2248032", "aliases": ["IL-33R", "IL-33 receptor activity"], "types": ["T044"], "canonical_name": "interleukin-33 receptor activity", "definition": "Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:hjd, GOC:signaling]"}
{"concept_id": "C2248033", "aliases": [], "types": ["T039"], "canonical_name": "activation of antimicrobial peptide production"}
{"concept_id": "C2248034", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antimicrobial peptide production"}
{"concept_id": "C2248036", "aliases": [], "types": ["T039"], "canonical_name": "activation of antiviral response by host"}
{"concept_id": "C2248037", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antiviral response by host"}
{"concept_id": "C2248038", "aliases": [], "types": ["T045"], "canonical_name": "activation of histone acetylation"}
{"concept_id": "C2248039", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of histone acetylation"}
{"concept_id": "C2248042", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of histone acetylation"}
{"concept_id": "C2248043", "aliases": [], "types": ["T044"], "canonical_name": "activation of sterol regulatory element binding protein target gene transcription"}
{"concept_id": "C2248044", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of sterol regulatory element binding protein target gene transcription"}
{"concept_id": "C2248045", "aliases": [], "types": ["T040"], "canonical_name": "limb bud morphogenesis"}
{"concept_id": "C2248046", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of terminal cell fate specification"}
{"concept_id": "C2248048", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fusion cell fate specification"}
{"concept_id": "C2248049", "aliases": [], "types": ["T026"], "canonical_name": "germline ring canal outer rim"}
{"concept_id": "C2248050", "aliases": [], "types": ["T026"], "canonical_name": "germline ring canal inner rim"}
{"concept_id": "C2248052", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lamellocyte differentiation"}
{"concept_id": "C2248053", "aliases": [], "types": ["T043"], "canonical_name": "activation of lamellocyte differentiation"}
{"concept_id": "C2248054", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of lamellocyte differentiation"}
{"concept_id": "C2248060", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of glutamate-cysteine ligase activity"}
{"concept_id": "C2248061", "aliases": [], "types": ["T040"], "canonical_name": "activation of glutamate-cysteine ligase activity"}
{"concept_id": "C2248062", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of glutamate-cysteine ligase activity"}
{"concept_id": "C2248064", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organism growth", "definition": "The increase in size or mass of an entire multicellular organism, as opposed to cell growth. [GOC:bf, GOC:curators, GOC:dph, GOC:tb]"}
{"concept_id": "C2248065", "aliases": ["negative regulation of translation involved in gene silencing by microRNA", "gene silencing by miRNA, negative regulation of translation", "miRNA mediated inhibition of translation", "downregulation of translation involved in gene silencing by miRNA", "down-regulation of translation involved in gene silencing by miRNA", "down regulation of translation involved in gene silencing by miRNA"], "types": ["T045"], "canonical_name": "miRNA-mediated gene silencing by inhibition of translation", "definition": "An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs. [PMID:14744438, PMID:15196554]"}
{"concept_id": "C2248072", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dephosphorylation"}
{"concept_id": "C2248073", "aliases": [], "types": ["T043"], "canonical_name": "activation of dephosphorylation"}
{"concept_id": "C2248074", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of dephosphorylation"}
{"concept_id": "C2248076", "aliases": [], "types": ["T040"], "canonical_name": "activation of protein amino acid dephosphorylation"}
{"concept_id": "C2248077", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of protein amino acid dephosphorylation"}
{"concept_id": "C2248078", "aliases": ["positive regulation of protein amino acid dephosphorylation", "upregulation of protein amino acid dephosphorylation", "up regulation of protein amino acid dephosphorylation", "up-regulation of protein amino acid dephosphorylation"], "types": ["T044"], "canonical_name": "positive regulation of protein dephosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. [GOC:bf]"}
{"concept_id": "C2248080", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of protein amino acid dephosphorylation"}
{"concept_id": "C2248082", "aliases": [], "types": ["T040"], "canonical_name": "activation of growth rate"}
{"concept_id": "C2248083", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of growth rate"}
{"concept_id": "C2248086", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of locomotion"}
{"concept_id": "C2248087", "aliases": [], "types": ["T055"], "canonical_name": "activation of locomotion"}
{"concept_id": "C2248088", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of locomotion"}
{"concept_id": "C2248090", "aliases": [], "types": ["T040"], "canonical_name": "activation of embryonic development"}
{"concept_id": "C2248091", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of embryonic development"}
{"concept_id": "C2248096", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of mRNA translation, ncRNA-mediated"}
{"concept_id": "C2248097", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mRNA translation, ncRNA-mediated"}
{"concept_id": "C2248099", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of fibroblast growth factor receptor signaling pathway"}
{"concept_id": "C2248106", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of epidermal growth factor receptor signaling pathway"}
{"concept_id": "C2248112", "aliases": [], "types": ["T043"], "canonical_name": "activation of T cell proliferation"}
{"concept_id": "C2248113", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T cell proliferation"}
{"concept_id": "C2248115", "aliases": [], "types": ["T043"], "canonical_name": "activation of T cell homeostatic proliferation"}
{"concept_id": "C2248116", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T cell homeostatic proliferation"}
{"concept_id": "C2248118", "aliases": [], "types": ["T043"], "canonical_name": "activation of activated T cell proliferation"}
{"concept_id": "C2248119", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of activated T cell proliferation"}
{"concept_id": "C2248125", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell proliferation"}
{"concept_id": "C2248126", "aliases": ["downregulation of sporulation", "down-regulation of sporulation", "down regulation of sporulation"], "types": ["T043"], "canonical_name": "negative regulation of sporulation resulting in formation of a cellular spore", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation. [GOC:go_curators]"}
{"concept_id": "C2248127", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sporulation"}
{"concept_id": "C2248129", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein catabolic process"}
{"concept_id": "C2248130", "aliases": ["asexual spore wall formation"], "types": ["T043"], "canonical_name": "asexual spore wall assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in Bacterial and Fungal species. [GOC:mah]"}
{"concept_id": "C2248136", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome c552 activity"}
{"concept_id": "C2248144", "aliases": ["hydroxymethylglutaryl coenzyme A reductase activity", "HMG-CoA reductase activity"], "types": ["T044"], "canonical_name": "HMG-CoA reductase activity"}
{"concept_id": "C2248151", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein import into nucleus"}
{"concept_id": "C2248152", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein import into nucleus"}
{"concept_id": "C2248155", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein import into nucleus"}
{"concept_id": "C2248179", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of circadian sleep/wake cycle, sleep"}
{"concept_id": "C2248181", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of circadian sleep/wake cycle, REM sleep"}
{"concept_id": "C2248183", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of circadian sleep/wake cycle, non-REM sleep"}
{"concept_id": "C2248185", "aliases": [], "types": ["T043"], "canonical_name": "activation of phosphorylation"}
{"concept_id": "C2248186", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of phosphorylation"}
{"concept_id": "C2248208", "aliases": [], "types": ["T043"], "canonical_name": "ocellus photoreceptor cell development", "definition": "Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus. [GOC:jl, ISBN:0192800981, PMID:11542766]"}
{"concept_id": "C2248210", "aliases": [], "types": ["T043"], "canonical_name": "activation of eye photoreceptor cell development"}
{"concept_id": "C2248211", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of eye photoreceptor cell development"}
{"concept_id": "C2248214", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of eye photoreceptor cell development"}
{"concept_id": "C2248215", "aliases": ["activation of odontogenesis"], "types": ["T042"], "canonical_name": "activation of odontogenesis"}
{"concept_id": "C2248216", "aliases": ["stimulation of odontogenesis"], "types": ["T042"], "canonical_name": "stimulation of odontogenesis"}
{"concept_id": "C2248219", "aliases": ["inhibition of odontogenesis"], "types": ["T042"], "canonical_name": "inhibition of odontogenesis"}
{"concept_id": "C2248226", "aliases": [], "types": ["T044"], "canonical_name": "activation of tyrosine phosphorylation of Stat1 protein"}
{"concept_id": "C2248227", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of tyrosine phosphorylation of Stat1 protein"}
{"concept_id": "C2248230", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tyrosine phosphorylation of Stat1 protein"}
{"concept_id": "C2248232", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tyrosine phosphorylation of Stat2 protein"}
{"concept_id": "C2248233", "aliases": [], "types": ["T044"], "canonical_name": "activation of tyrosine phosphorylation of Stat2 protein"}
{"concept_id": "C2248234", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of tyrosine phosphorylation of Stat2 protein"}
{"concept_id": "C2248236", "aliases": [], "types": ["T044"], "canonical_name": "activation of tyrosine phosphorylation of Stat3 protein"}
{"concept_id": "C2248237", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of tyrosine phosphorylation of Stat3 protein"}
{"concept_id": "C2248240", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tyrosine phosphorylation of Stat3 protein"}
{"concept_id": "C2248241", "aliases": [], "types": ["T044"], "canonical_name": "activation of tyrosine phosphorylation of Stat4 protein"}
{"concept_id": "C2248242", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of tyrosine phosphorylation of Stat4 protein"}
{"concept_id": "C2248245", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tyrosine phosphorylation of Stat4 protein"}
{"concept_id": "C2248246", "aliases": [], "types": ["T044"], "canonical_name": "activation of tyrosine phosphorylation of Stat5 protein"}
{"concept_id": "C2248247", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of tyrosine phosphorylation of Stat5 protein"}
{"concept_id": "C2248250", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tyrosine phosphorylation of Stat5 protein"}
{"concept_id": "C2248251", "aliases": [], "types": ["T044"], "canonical_name": "activation of tyrosine phosphorylation of Stat6 protein"}
{"concept_id": "C2248252", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of tyrosine phosphorylation of Stat6 protein"}
{"concept_id": "C2248255", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tyrosine phosphorylation of Stat6 protein"}
{"concept_id": "C2248256", "aliases": [], "types": ["T044"], "canonical_name": "activation of tyrosine phosphorylation of Stat7 protein"}
{"concept_id": "C2248257", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of tyrosine phosphorylation of Stat7 protein"}
{"concept_id": "C2248260", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tyrosine phosphorylation of Stat7 protein"}
{"concept_id": "C2248261", "aliases": [], "types": ["T043"], "canonical_name": "activation of tyrosine phosphorylation of STAT protein"}
{"concept_id": "C2248262", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of tyrosine phosphorylation of STAT protein"}
{"concept_id": "C2248265", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of tyrosine phosphorylation of STAT protein"}
{"concept_id": "C2248278", "aliases": [], "types": ["T044"], "canonical_name": "NADPH-specific FMN reductase activity"}
{"concept_id": "C2248283", "aliases": ["riboflavin mononucleotide reductase activity", "riboflavine mononucleotide reductase activity"], "types": ["T044"], "canonical_name": "riboflavin mononucleotide reductase activity"}
{"concept_id": "C2248288", "aliases": [], "types": ["T040"], "canonical_name": "activation of hair cycle"}
{"concept_id": "C2248289", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of hair cycle"}
{"concept_id": "C2248292", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of hair cycle"}
{"concept_id": "C2248293", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell fate specification"}
{"concept_id": "C2248294", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell fate specification"}
{"concept_id": "C2248297", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mesodermal cell fate specification"}
{"concept_id": "C2248299", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endodermal cell fate specification"}
{"concept_id": "C2248301", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ectodermal cell fate specification"}
{"concept_id": "C2248302", "aliases": [], "types": ["T043"], "canonical_name": "compound eye cone cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye. [GOC:mtg_sensu]"}
{"concept_id": "C2248303", "aliases": [], "types": ["T043"], "canonical_name": "compound eye cone cell fate commitment", "definition": "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type. [GOC:mtg_sensu]"}
{"concept_id": "C2248304", "aliases": [], "types": ["T043"], "canonical_name": "compound eye cone cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:mtg_sensu]"}
{"concept_id": "C2248305", "aliases": [], "types": ["T043"], "canonical_name": "compound eye cone cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:mtg_sensu]"}
{"concept_id": "C2248306", "aliases": [], "types": ["T043"], "canonical_name": "regulation of compound eye cone cell fate specification", "definition": "Any process that mediates the specification of a cell into a compound eye cone cell. [GOC:mtg_sensu]"}
{"concept_id": "C2248307", "aliases": ["downregulation of cone cell fate specification", "down regulation of cone cell fate specification", "inhibition of cone cell fate specification", "down-regulation of cone cell fate specification", "suppression of cone cell fate"], "types": ["T043"], "canonical_name": "negative regulation of compound eye cone cell fate specification", "definition": "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell. [GOC:mtg_sensu]"}
{"concept_id": "C2248311", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of crystal cell differentiation"}
{"concept_id": "C2248312", "aliases": [], "types": ["T043"], "canonical_name": "activation of crystal cell differentiation"}
{"concept_id": "C2248313", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of crystal cell differentiation"}
{"concept_id": "C2248315", "aliases": [], "types": ["T040"], "canonical_name": "ovulation cycle", "definition": "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. [ISBN:0721662544]"}
{"concept_id": "C2248320", "aliases": [], "types": ["T039"], "canonical_name": "activation of circadian rhythm"}
{"concept_id": "C2248321", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of circadian rhythm"}
{"concept_id": "C2248324", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of circadian rhythm"}
{"concept_id": "C2248325", "aliases": [], "types": ["T026"], "canonical_name": "intracellular immature spore", "definition": "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants. [GOC:jl, ISBN:0395825172]"}
{"concept_id": "C2248326", "aliases": [], "types": ["T026"], "canonical_name": "ascospore-type prospore", "definition": "An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi. [GOC:go_curators]"}
{"concept_id": "C2248327", "aliases": [], "types": ["T045"], "canonical_name": "tRNAse Z"}
{"concept_id": "C2248329", "aliases": [], "types": ["T044"], "canonical_name": "aldarate transmembrane transporter activity", "definition": "Enables the transfer of aldarate from one side of a membrane to the other. [GOC:go_curators, PMID:15034926]"}
{"concept_id": "C2248330", "aliases": [], "types": ["T044"], "canonical_name": "aldonate transmembrane transporter activity", "definition": "Enables the transfer of aldonate from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2248331", "aliases": [], "types": ["T044"], "canonical_name": "colicin transmembrane transporter activity", "definition": "Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1. [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:17347522]"}
{"concept_id": "C2248332", "aliases": [], "types": ["T044"], "canonical_name": "D-amino acid transmembrane transporter activity", "definition": "Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids. [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2248333", "aliases": [], "types": ["T044"], "canonical_name": "D-alanine transmembrane transporter activity", "definition": "Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2248334", "aliases": ["D-serine permease activity"], "types": ["T044"], "canonical_name": "D-serine transmembrane transporter activity", "definition": "Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid. [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2248335", "aliases": [], "types": ["T044"], "canonical_name": "antimonite secondary active transmembrane transporter activity", "definition": "Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:jl]"}
{"concept_id": "C2248336", "aliases": [], "types": ["T044"], "canonical_name": "homoserine transmembrane transporter activity", "definition": "Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C2248338", "aliases": ["beta-glucanase activity", "beta-D-glucanase activity"], "types": ["T044"], "canonical_name": "beta-glucanase activity", "definition": "Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds. [Wikipedia:Beta-glucan]"}
{"concept_id": "C2248340", "aliases": [], "types": ["T044"], "canonical_name": "mixed linkage beta-glucanase activity"}
{"concept_id": "C2248345", "aliases": [], "types": ["T044"], "canonical_name": "beta-1,3-glucanase"}
{"concept_id": "C2248347", "aliases": ["endo-(1->3)-beta-D-glucanase activity"], "types": ["T044"], "canonical_name": "endo-(1,3)-beta-D-glucanase activity", "definition": "OBSOLETE. Catalysis of the endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. [EC:3.2.1.6]"}
{"concept_id": "C2248348", "aliases": [], "types": ["T044"], "canonical_name": "endo-1,3-beta-D-glucanase"}
{"concept_id": "C2248349", "aliases": [], "types": ["T044"], "canonical_name": "endo-1,3-beta-glucosidase activity"}
{"concept_id": "C2248351", "aliases": [], "types": ["T044"], "canonical_name": "oligo-1,3-glucosidase activity"}
{"concept_id": "C2248353", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amyloid precursor protein biosynthetic process"}
{"concept_id": "C2248354", "aliases": [], "types": ["T040"], "canonical_name": "activation of amyloid precursor protein biosynthetic process"}
{"concept_id": "C2248355", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of amyloid precursor protein biosynthetic process"}
{"concept_id": "C2248363", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Golgi to plasma membrane protein transport"}
{"concept_id": "C2248364", "aliases": [], "types": ["T043"], "canonical_name": "activation of Golgi to plasma membrane protein transport"}
{"concept_id": "C2248365", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of Golgi to plasma membrane protein transport"}
{"concept_id": "C2248368", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Golgi to plasma membrane CFTR protein transport"}
{"concept_id": "C2248369", "aliases": [], "types": ["T043"], "canonical_name": "activation of Golgi to plasma membrane CFTR protein transport"}
{"concept_id": "C2248370", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of Golgi to plasma membrane CFTR protein transport"}
{"concept_id": "C2248373", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fusion of sperm to egg plasma membrane"}
{"concept_id": "C2248378", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of macrophage activation"}
{"concept_id": "C2248379", "aliases": [], "types": ["T043"], "canonical_name": "activation of macrophage activation"}
{"concept_id": "C2248380", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of macrophage activation"}
{"concept_id": "C2248382", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of apoptosis"}
{"concept_id": "C2248385", "aliases": [], "types": ["T043"], "canonical_name": "activation of programmed cell death"}
{"concept_id": "C2248386", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of programmed cell death"}
{"concept_id": "C2248389", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of programmed cell death"}
{"concept_id": "C2248395", "aliases": [], "types": ["T040"], "canonical_name": "activation of enzyme activity"}
{"concept_id": "C2248396", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of enzyme activity"}
{"concept_id": "C2248397", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of enzyme activity"}
{"concept_id": "C2248398", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of Cdc42 GTPase activity"}
{"concept_id": "C2248400", "aliases": [], "types": ["T040"], "canonical_name": "activation of GTP cyclohydrolase I activity"}
{"concept_id": "C2248401", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of GTP cyclohydrolase I activity"}
{"concept_id": "C2248404", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of GTP cyclohydrolase I activity"}
{"concept_id": "C2248408", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of vascular permeability"}
{"concept_id": "C2248409", "aliases": [], "types": ["T039"], "canonical_name": "activation of vascular permeability"}
{"concept_id": "C2248410", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of vascular permeability"}
{"concept_id": "C2248412", "aliases": [], "types": ["T044"], "canonical_name": "activation of I-kappaB kinase/NF-kappaB cascade"}
{"concept_id": "C2248413", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of I-kappaB kinase/NF-kappaB cascade"}
{"concept_id": "C2248416", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of I-kappaB kinase/NF-kappaB cascade"}
{"concept_id": "C2248418", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1-phosphatidylinositol 4-kinase activity"}
{"concept_id": "C2248419", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1-phosphatidylinositol 4-kinase activity"}
{"concept_id": "C2248420", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of 1-phosphatidylinositol 4-kinase activity"}
{"concept_id": "C2248424", "aliases": ["inhibition of caspase activity"], "types": ["T044"], "canonical_name": "inhibition of caspase activity"}
{"concept_id": "C2248426", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of photosynthesis, light reaction"}
{"concept_id": "C2248432", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of protein complex disassembly"}
{"concept_id": "C2248433", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein complex disassembly"}
{"concept_id": "C2248434", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of protein complex disassembly"}
{"concept_id": "C2248441", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of potassium ion transport"}
{"concept_id": "C2248442", "aliases": [], "types": ["T043"], "canonical_name": "activation of potassium ion transport"}
{"concept_id": "C2248443", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of potassium ion transport"}
{"concept_id": "C2248445", "aliases": [], "types": ["T043"], "canonical_name": "activation of ion transport"}
{"concept_id": "C2248446", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of ion transport"}
{"concept_id": "C2248449", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ion transport"}
{"concept_id": "C2248469", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of caspase activity"}
{"concept_id": "C2248470", "aliases": ["up regulation of caspase activity", "up-regulation of caspase activity", "upregulation of caspase activity"], "types": ["T040"], "canonical_name": "positive regulation of cysteine-type endopeptidase activity involved in apoptotic process", "definition": "Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis]"}
{"concept_id": "C2248472", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of leukocyte degranulation"}
{"concept_id": "C2248473", "aliases": [], "types": ["T043"], "canonical_name": "activation of leukocyte degranulation"}
{"concept_id": "C2248474", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of leukocyte degranulation"}
{"concept_id": "C2248477", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mast cell degranulation"}
{"concept_id": "C2248478", "aliases": [], "types": ["T043"], "canonical_name": "activation of mast cell degranulation"}
{"concept_id": "C2248479", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mast cell degranulation"}
{"concept_id": "C2248482", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of eosinophil degranulation"}
{"concept_id": "C2248483", "aliases": [], "types": ["T043"], "canonical_name": "activation of eosinophil degranulation"}
{"concept_id": "C2248484", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of eosinophil degranulation"}
{"concept_id": "C2248486", "aliases": [], "types": ["T039"], "canonical_name": "heterophil degranulation"}
{"concept_id": "C2248488", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil degranulation"}
{"concept_id": "C2248489", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil degranulation"}
{"concept_id": "C2248490", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neutrophil degranulation"}
{"concept_id": "C2248493", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytotoxic T cell degranulation"}
{"concept_id": "C2248494", "aliases": [], "types": ["T043"], "canonical_name": "activation of cytotoxic T cell degranulation"}
{"concept_id": "C2248495", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cytotoxic T cell degranulation"}
{"concept_id": "C2248498", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell degranulation"}
{"concept_id": "C2248499", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell degranulation"}
{"concept_id": "C2248500", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell degranulation"}
{"concept_id": "C2248503", "aliases": ["negative regulation of CD4-positive, alpha beta T-cell differentiation", "negative regulation of CD4-positive T-lymphocyte differentiation", "down regulation of CD4-positive, alpha beta T cell differentiation", "downregulation of CD4-positive, alpha beta T cell differentiation", "negative regulation of CD4-positive T-cell differentiation", "negative regulation of CD4-positive, alpha beta T lymphocyte differentiation", "down-regulation of CD4-positive, alpha beta T cell differentiation", "negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of CD4-positive, alpha-beta T cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. [GOC:add, GOC:pr, ISBN:0781735149]"}
{"concept_id": "C2248504", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of CD4-positive, alpha beta T cell differentiation"}
{"concept_id": "C2248505", "aliases": [], "types": ["T043"], "canonical_name": "activation of CD4-positive, alpha beta T cell differentiation"}
{"concept_id": "C2248506", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of CD4-positive, alpha beta T cell differentiation"}
{"concept_id": "C2248507", "aliases": ["up-regulation of CD4-positive, alpha beta T cell differentiation", "up regulation of CD4-positive, alpha beta T cell differentiation", "positive regulation of CD4-positive T lymphocyte differentiation", "positive regulation of CD4-positive T-cell differentiation", "positive regulation of CD4-positive T-lymphocyte differentiation", "upregulation of CD4-positive, alpha beta T cell differentiation", "positive regulation of CD4-positive, alpha beta T lymphocyte differentiation", "positive regulation of CD4-positive, alpha beta T cell differentiation", "positive regulation of CD4-positive, alpha beta T-cell differentiation", "positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of CD4-positive, alpha-beta T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation. [GOC:add, GOC:pr, ISBN:0781735149]"}
{"concept_id": "C2248509", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of CD8-positive, alpha-beta T cell differentiation"}
{"concept_id": "C2248510", "aliases": [], "types": ["T043"], "canonical_name": "activation of CD8-positive, alpha-beta T cell differentiation"}
{"concept_id": "C2248511", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of CD8-positive, alpha-beta T cell differentiation"}
{"concept_id": "C2248514", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of memory T cell differentiation"}
{"concept_id": "C2248515", "aliases": [], "types": ["T043"], "canonical_name": "activation of memory T cell differentiation"}
{"concept_id": "C2248516", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of memory T cell differentiation"}
{"concept_id": "C2248518", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA binding"}
{"concept_id": "C2248519", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of DNA binding"}
{"concept_id": "C2248522", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA binding"}
{"concept_id": "C2248524", "aliases": [], "types": ["T042"], "canonical_name": "myofiber turnover"}
{"concept_id": "C2248525", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of MAPK activity"}
{"concept_id": "C2248526", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of MAPK activity"}
{"concept_id": "C2248527", "aliases": ["negative regulation of mitogen-activated protein kinase cascade", "down regulation of MAPKKK cascade", "negative regulation of MAP kinase kinase kinase cascade", "down-regulation of MAPK cascade", "down regulation of MAPK cascade", "downregulation of MAPKKK cascade", "negative regulation of mitogen activated protein kinase kinase kinase cascade", "negative regulation of mitogen-activated protein kinase kinase kinase cascade", "negative regulation of mitogen activated protein kinase cascade", "down-regulation of MAPKKK cascade", "negative regulation of MAP kinase cascade", "downregulation of MAPK cascade", "negative regulation of MAPKKK cascade"], "types": ["T044"], "canonical_name": "negative regulation of MAPK cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. [GOC:go_curators]"}
{"concept_id": "C2248528", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of MAPKKK cascade"}
{"concept_id": "C2248529", "aliases": [], "types": ["T040"], "canonical_name": "activation of MAPKKK cascade"}
{"concept_id": "C2248532", "aliases": [], "types": ["T040"], "canonical_name": "activation of skeletal muscle regeneration"}
{"concept_id": "C2248533", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of skeletal muscle regeneration"}
{"concept_id": "C2248534", "aliases": ["up regulation of skeletal muscle regeneration", "upregulation of skeletal muscle regeneration", "up-regulation of skeletal muscle regeneration"], "types": ["T040"], "canonical_name": "positive regulation of skeletal muscle tissue regeneration", "definition": "Any process that activates or increase the rate of skeletal muscle regeneration. [GOC:jl]"}
{"concept_id": "C2248535", "aliases": ["down-regulation of skeletal muscle regeneration", "down regulation of skeletal muscle regeneration", "downregulation of skeletal muscle regeneration"], "types": ["T040"], "canonical_name": "negative regulation of skeletal muscle tissue regeneration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration. [GOC:jl]"}
{"concept_id": "C2248536", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of skeletal muscle regeneration"}
{"concept_id": "C2248542", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription factor activity"}
{"concept_id": "C2248544", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of kinin cascade"}
{"concept_id": "C2248545", "aliases": [], "types": ["T039"], "canonical_name": "activation of kinin cascade"}
{"concept_id": "C2248546", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of kinin cascade"}
{"concept_id": "C2248549", "aliases": [], "types": ["T040"], "canonical_name": "regulation of protein homodimerization activity", "definition": "Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. [GOC:jl, GOC:tb]"}
{"concept_id": "C2248550", "aliases": [], "types": ["T040"], "canonical_name": "regulation of protein heterodimerization activity", "definition": "Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer. [GOC:jl, GOC:tb]"}
{"concept_id": "C2248551", "aliases": [], "types": ["T039"], "canonical_name": "muscle adaptation", "definition": "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]"}
{"concept_id": "C2248552", "aliases": [], "types": ["T039"], "canonical_name": "skeletal muscle adaptation", "definition": "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]"}
{"concept_id": "C2248553", "aliases": [], "types": ["T039"], "canonical_name": "regulation of muscle adaptation", "definition": "Any process that modulates the frequency, rate or extent of muscle adaptation. [GOC:go_curators, GOC:mtg_muscle]"}
{"concept_id": "C2248554", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of JNK activity"}
{"concept_id": "C2248555", "aliases": ["upregulation of JNK activity", "up regulation of JNK activity", "up-regulation of JNK activity", "positive regulation of JUNK activity"], "types": ["T044"], "canonical_name": "positive regulation of JUN kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of JUN kinase activity. [GOC:jl]"}
{"concept_id": "C2248556", "aliases": ["negative regulation of JUNK activity", "down regulation of JNK activity", "down-regulation of JNK activity", "downregulation of JNK activity"], "types": ["T044"], "canonical_name": "negative regulation of JUN kinase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. [GOC:jl]"}
{"concept_id": "C2248557", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of JNK activity"}
{"concept_id": "C2248558", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA damage response, signal transduction by p53 class mediator"}
{"concept_id": "C2248559", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of DNA damage response, signal transduction by p53 class mediator"}
{"concept_id": "C2248562", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA damage response, signal transduction by p53 class mediator"}
{"concept_id": "C2248564", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuron apoptosis"}
{"concept_id": "C2248565", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuron apoptosis"}
{"concept_id": "C2248566", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neuron apoptosis"}
{"concept_id": "C2248569", "aliases": [], "types": ["T043"], "canonical_name": "activation of blood vessel endothelial cell migration"}
{"concept_id": "C2248570", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of blood vessel endothelial cell migration"}
{"concept_id": "C2248573", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of blood vessel endothelial cell migration"}
{"concept_id": "C2248574", "aliases": ["activation of GTPase activity"], "types": ["T044"], "canonical_name": "activation of GTPase activity", "definition": "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2248575", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of GTPase activity"}
{"concept_id": "C2248582", "aliases": ["regulation of translation initiation in response to stress"], "types": ["T043"], "canonical_name": "regulation of translational initiation in response to stress", "definition": "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. [GOC:jl]"}
{"concept_id": "C2248583", "aliases": [], "types": ["T045"], "canonical_name": "regulation of translational initiation in response to osmotic stress", "definition": "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C2248584", "aliases": [], "types": ["T044"], "canonical_name": "activation of insulin-like growth factor receptor signaling pathway"}
{"concept_id": "C2248585", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of insulin-like growth factor receptor signaling pathway"}
{"concept_id": "C2248588", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of insulin-like growth factor receptor signaling pathway"}
{"concept_id": "C2248589", "aliases": [], "types": ["T045"], "canonical_name": "conversion of glutamyl-tRNA to glutaminyl-tRNA", "definition": "The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA. [GOC:jsg, PMID:3340166, PMID:9342308]"}
{"concept_id": "C2248590", "aliases": [], "types": ["T045"], "canonical_name": "conversion of aspartyl-tRNA to asparaginyl-tRNA", "definition": "The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA. [GOC:jsg, PMID:9789001]"}
{"concept_id": "C2248593", "aliases": [], "types": ["T043"], "canonical_name": "reverse cholesterol transport", "definition": "The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. [GOC:ecd, PMID:7751809]"}
{"concept_id": "C2248594", "aliases": [], "types": ["T043"], "canonical_name": "detection of pheromone", "definition": "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal. [GOC:mah]"}
{"concept_id": "C2248595", "aliases": [], "types": ["T043"], "definition": "The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors. [GOC:dph, GOC:pg]", "canonical_name": "dedifferentiation"}
{"concept_id": "C2248596", "aliases": ["reflecting platelet"], "types": ["T026"], "canonical_name": "iridosome", "definition": "A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance. [GOC:mh]"}
{"concept_id": "C2248597", "aliases": ["refractosome"], "types": ["T026"], "canonical_name": "leucosome", "definition": "A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast. [GOC:mh]"}
{"concept_id": "C2248598", "aliases": [], "types": ["T026"], "canonical_name": "pterinosome", "definition": "A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance. [GOC:mh]"}
{"concept_id": "C2248599", "aliases": [], "types": ["T026"], "canonical_name": "cyanosome", "definition": "A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance. [GOC:mh]"}
{"concept_id": "C2248600", "aliases": [], "types": ["T026"], "canonical_name": "carotenoid vesicle", "definition": "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vesicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance. [GOC:mh]"}
{"concept_id": "C2248601", "aliases": [], "types": ["T043"], "canonical_name": "photoreceptor cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:mtg_sensu]"}
{"concept_id": "C2248602", "aliases": [], "types": ["T043"], "canonical_name": "photoreceptor cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [GOC:mtg_sensu]"}
{"concept_id": "C2248603", "aliases": ["multi-L-arginyl-poly(L-aspartic acid) metabolism", "cyanophycin metabolism"], "types": ["T044"], "canonical_name": "cyanophycin metabolic process", "definition": "The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups. [GOC:jl]"}
{"concept_id": "C2248605", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion during single-species biofilm formation in or on host organism"}
{"concept_id": "C2248606", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion during biofilm formation"}
{"concept_id": "C2248607", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion during single-species biofilm formation"}
{"concept_id": "C2248608", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion during multi-species biofilm formation"}
{"concept_id": "C2248609", "aliases": ["pilus organisation", "pilus organization and biogenesis"], "types": ["T043"], "canonical_name": "pilus organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. [GOC:jl]"}
{"concept_id": "C2248610", "aliases": ["(R)-2-hydroxyisocaproate CoA-transferase activity", "(R)-2-hydroxyisocaproate CoA transferase activity"], "types": ["T044"], "canonical_name": "2-hydroxyisocaproate CoA-transferase activity", "definition": "Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate. [PMID:16957230]"}
{"concept_id": "C2248611", "aliases": [], "types": ["T044"], "canonical_name": "(R)-2-hydroxyisocaproate dehydrogenase activity", "definition": "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+. [GOC:jl, PMID:16957230]"}
{"concept_id": "C2248612", "aliases": [], "types": ["T044"], "canonical_name": "(R)-citramalate synthase activity", "definition": "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA. [GOC:jl, PMID:9864346]"}
{"concept_id": "C2248613", "aliases": [], "types": ["T044"], "canonical_name": "citramalate synthase"}
{"concept_id": "C2248614", "aliases": ["MasA", "2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity", "E-1", "DK-MTP-1-P enolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P. [MetaCyc:R82-RXN]", "canonical_name": "mtnW"}
{"concept_id": "C2248615", "aliases": ["HK-MTPenyl-1-P phosphatase activity", "2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity"], "types": ["T044"], "canonical_name": "2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity", "definition": "Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene. [EC:3.1.3.77, MetaCyc:R83-RXN]"}
{"concept_id": "C2248616", "aliases": ["(R)-2-hydroxyglutaryl-CoA dehydratase activity"], "types": ["T044"], "canonical_name": "2-hydroxyglutaryl-CoA dehydratase activity", "definition": "Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA. [MetaCyc:RXN-1083]"}
{"concept_id": "C2248617", "aliases": ["HgD", "(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH. [EC:1.1.1.291, RHEA:15505]", "canonical_name": "2-hydroxymethylglutarate dehydrogenase activity"}
{"concept_id": "C2248619", "aliases": ["3-keto-5-aminohexanoate cleavage enzyme"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate. [MetaCyc:R125-RXN, PMID:13064]", "canonical_name": "3-keto-5-aminohexanoate cleavage activity"}
{"concept_id": "C2248620", "aliases": ["gamma-hydroxybutanoyl-CoA dehydratase activity", "4-hydroxybutanoyl-CoA hydro-lyase", "4-hydroxybutyryl-CoA dehydratase activity", "gamma-hydroxybutyryl-CoA dehydratase activity"], "types": ["T044"], "canonical_name": "4-hydroxybutanoyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O. [EC:4.2.1.120]"}
{"concept_id": "C2248621", "aliases": ["p-hydroxyphenylacetate decarboxylase activity", "4-Hpd activity", "4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)", "4-hydroxyphenylacetate carboxy-lyase activity", "p-Hpd activity"], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetate decarboxylase activity", "definition": "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H(+) = 4-cresol + CO(2). [EC:4.1.1.83, RHEA:22732]"}
{"concept_id": "C2248622", "aliases": ["2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity", "2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia. [MetaCyc:RXN-10058, PMID:11889103]", "canonical_name": "DRAP deaminase activity"}
{"concept_id": "C2248623", "aliases": ["KDGal aldolase activity"], "types": ["T044"], "canonical_name": "2-keto-3-deoxygalactonate aldolase activity", "definition": "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate. [PMID:12824170]"}
{"concept_id": "C2248625", "aliases": ["pyrimidine phosphatase activity"], "types": ["T044"], "canonical_name": "5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity", "definition": "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate. [GOC:jl]"}
{"concept_id": "C2248626", "aliases": [], "types": ["T044"], "canonical_name": "5-amino-4-imidazole carboxylate lyase activity", "definition": "Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate. [GOC:jl]"}
{"concept_id": "C2248627", "aliases": [], "types": ["T044"], "canonical_name": "2-keto-4-methylthiobutyrate aminotransferase activity", "definition": "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine. [GOC:jl]"}
{"concept_id": "C2248628", "aliases": [], "types": ["T044"], "canonical_name": "2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity", "definition": "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+. [RHEA:27282]"}
{"concept_id": "C2248629", "aliases": [], "types": ["T044"], "canonical_name": "5-ureido-4-imidazole carboxylate hydrolase activity", "definition": "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2. [GOC:jl]"}
{"concept_id": "C2248630", "aliases": [], "types": ["T044"], "canonical_name": "6-hydroxynicotinate 3-monooxygenase activity", "definition": "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD. [GOC:jl, PMID:10091591]"}
{"concept_id": "C2248631", "aliases": ["6-hydroxynicotinic acid dehydrogenase activity", "6-hydroxynicotinate:O2 oxidoreductase activity", "6-hydroxynicotinic acid hydroxylase activity", "6-hydroxynicotinate hydroxylase activity"], "types": ["T044"], "canonical_name": "6-hydroxynicotinate dehydrogenase activity", "definition": "Catalysis of the reaction: 6-hydroxynicotinate + H(2)O + O(2) = 2,6-dihydroxynicotinate + H(2)O(2). [EC:1.17.3.3, RHEA:22808]"}
{"concept_id": "C2248632", "aliases": ["MagIII", "Mag III"], "types": ["T045"], "canonical_name": "DNA-3-methylbase glycosylase activity", "definition": "Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site. [PMID:10777493, PMID:14517230]"}
{"concept_id": "C2248633", "aliases": ["DNA-N1-methyladenine dioxygenase activity"], "types": ["T045"], "definition": "Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde. [PMID:19786499]", "canonical_name": "AlkB"}
{"concept_id": "C2248634", "aliases": [], "types": ["T044"], "canonical_name": "alpha-ketoglutarate-dependent dioxygenase"}
{"concept_id": "C2248637", "aliases": ["DNase V activity", "endodeoxyribonuclease V"], "types": ["T045"], "definition": "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate. [EC:3.1.21.7]", "canonical_name": "deoxyribonuclease V activity"}
{"concept_id": "C2248638", "aliases": ["endonuclease V activity"], "types": ["T045"], "canonical_name": "endonuclease V activity"}
{"concept_id": "C2248639", "aliases": [], "types": ["T045"], "canonical_name": "Escherichia coli endodeoxyribonuclease V activity"}
{"concept_id": "C2248640", "aliases": ["F420H2 dehydrogenase activity", "1,5-dihydrocoenzyme F420 dehydrogenase activity"], "types": ["T044"], "canonical_name": "reduced coenzyme F420 dehydrogenase activity", "definition": "Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420. [MetaCyc:RXN-8106]"}
{"concept_id": "C2248641", "aliases": ["MUG", "GU mismatch-specific uracil-DNA glycosylase activity"], "types": ["T044"], "definition": "Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site. [PMID:24739389]", "canonical_name": "G/U mismatch-specific uracil-DNA glycosylase activity"}
{"concept_id": "C2248642", "aliases": [], "types": ["T045"], "canonical_name": "uracil mismatch repair protein"}
{"concept_id": "C2248643", "aliases": ["GTP 8,9-hydrolase (phosphate-forming)", "GTP 8,9-dihydrolase (phosphate-forming)"], "types": ["T044"], "canonical_name": "GTP cyclohydrolase IIa activity", "definition": "Catalysis of the reaction: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H(+) + 2 phosphate. [EC:3.5.4.29, RHEA:22468]"}
{"concept_id": "C2248644", "aliases": [], "types": ["T044"], "canonical_name": "GTP cyclohydrolase III activity"}
{"concept_id": "C2248645", "aliases": [], "types": ["T044"], "canonical_name": "L-2-aminoadipate N-acetyltransferase activity"}
{"concept_id": "C2248646", "aliases": [], "types": ["T044"], "canonical_name": "LPPG:FO 2-phospho-L-lactate transferase activity", "definition": "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP. [PMID:11888293]"}
{"concept_id": "C2248647", "aliases": ["N-acetylaminoadipate kinase activity", "N-acetyl-L-aminoadipate 5-phosphotransferase activity", "acetylaminoadipate kinase activity"], "types": ["T044"], "canonical_name": "N2-acetyl-L-aminoadipate kinase activity", "definition": "Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate. [PMID:25392000, PMID:26966182, RHEA:41944]"}
{"concept_id": "C2248651", "aliases": [], "types": ["T044"], "canonical_name": "O-succinylbenzoate synthase activity", "definition": "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate. [PMID:8335646]"}
{"concept_id": "C2248652", "aliases": ["phenol:water dikinase activity", "ATP:phenol:water phosphotransferase activity", "phenylphosphate synthase activity"], "types": ["T044"], "canonical_name": "phenol, water dikinase activity", "definition": "Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate. [PMID:15547277]"}
{"concept_id": "C2248653", "aliases": ["GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity", "guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity", "GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity", "GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity", "phosphatidyl-myo-inositol alpha-mannosyltransferase activity", "GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol alpha-mannosyltransferase activity", "definition": "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol. [EC:2.4.1.345]"}
{"concept_id": "C2248654", "aliases": ["adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase", "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase", "RTP:adenosylcobinamide phosphotransferase activity", "CobU"], "types": ["T044"], "definition": "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP). [EC:2.7.1.156]", "canonical_name": "adenosylcobinamide kinase activity"}
{"concept_id": "C2248657", "aliases": ["enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity", "dihydrolipoyl transacylase activity", "2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity", "2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity"], "types": ["T044"], "canonical_name": "dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity", "definition": "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine. [EC:2.3.1.168]"}
{"concept_id": "C2248658", "aliases": ["CobC", "alpha-ribazole-5'-P phosphatase activity", "alpha-ribazole-5'-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "alpha-ribazole phosphatase activity", "definition": "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate. [EC:3.1.3.73, RHEA:24456]"}
{"concept_id": "C2248659", "aliases": ["AdoCbi amidohydrolase activity", "AdoCbi hydrolase activity", "adenosylcobinamide amidohydrolase activity", "CbiZ"], "types": ["T044"], "canonical_name": "adenosylcobinamide hydrolase activity", "definition": "Catalysis of the reaction: adenosylcobinamide + H(2)O = (R)-1-aminopropan-2-ol + adenosylcobyrate. [EC:3.5.1.90, RHEA:23504]"}
{"concept_id": "C2248660", "aliases": ["CbiB", "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)", "AdoCbi-P synthase activity"], "types": ["T044"], "canonical_name": "adenosylcobinamide-phosphate synthase activity", "definition": "Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide. [EC:6.3.1.10]"}
{"concept_id": "C2248661", "aliases": ["acetyl-CoA synthetase (ADP-forming) activity", "acetate-CoA ligase (ADP-forming) activity", "acetyl coenzyme A synthetase (adenosine diphosphate-forming)", "acetate--CoA ligase (ADP-forming) activity", "acetate thiokinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA. [RHEA:15081]", "canonical_name": "acetate:CoA ligase (ADP-forming)"}
{"concept_id": "C2248663", "aliases": ["branched-chain acyl-CoA synthetase (ADP-forming) activity", "branched-chain acyl CoA synthetase (ADP-forming) activity", "branched chain acyl CoA synthetase (ADP-forming) activity", "branched chain acyl-CoA synthetase (ADP-forming) activity"], "types": ["T044"], "canonical_name": "methylbutanoate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = AMP + diphosphate + 2-methylbutanoyl-CoA. [RHEA:46180]"}
{"concept_id": "C2248664", "aliases": ["N-acetyl-L,L-diaminopimelate aminotransferase activity", "N-acetyl-diaminopimelate aminotransferase activity"], "types": ["T044"], "canonical_name": "acetyldiaminopimelate aminotransferase activity", "definition": "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate. [PMID:1906065]"}
{"concept_id": "C2248665", "aliases": ["CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity", "CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity"], "types": ["T044"], "canonical_name": "archaetidylserine synthase activity", "definition": "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP. [PMID:12562787]"}
{"concept_id": "C2248667", "aliases": ["UDP-glucose diphosphorylase regulator activity", "glucose-1-phosphate uridylyltransferase regulator activity", "UDP-glucose pyrophosphorylase regulator activity"], "types": ["T044"], "canonical_name": "UTP:glucose-1-phosphate uridylyltransferase regulator activity", "definition": "Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase. [GOC:jl]"}
{"concept_id": "C2248668", "aliases": [], "types": ["T044"], "canonical_name": "UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity"}
{"concept_id": "C2248669", "aliases": [], "types": ["T045"], "canonical_name": "T/G mismatch-specific endonuclease activity", "definition": "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine. [PMID:17651368]"}
{"concept_id": "C2248670", "aliases": [], "types": ["T045"], "canonical_name": "DNA mismatch endonuclease"}
{"concept_id": "C2248671", "aliases": [], "types": ["T045"], "canonical_name": "V.EcoKDcm"}
{"concept_id": "C2248672", "aliases": [], "types": ["T045"], "canonical_name": "very short patch repair protein"}
{"concept_id": "C2248673", "aliases": [], "types": ["T045"], "canonical_name": "Vsr mismatch endonuclease"}
{"concept_id": "C2248674", "aliases": ["Sep-tRNA:Cys-tRNA synthetase activity", "O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity"], "types": ["T044"], "canonical_name": "Sep-tRNA:Cys-tRNA synthase activity", "definition": "Catalysis of the reaction: O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate. [PMID:15790858, PMID:16380427, PMID:17110438]"}
{"concept_id": "C2248675", "aliases": [], "types": ["T044"], "canonical_name": "SepCysS"}
{"concept_id": "C2248676", "aliases": ["PylRS", "pyrrolysine-tRNA ligase activity"], "types": ["T044"], "canonical_name": "pyrrolysyl-tRNA synthetase activity", "definition": "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl). [PMID:15314242, RHEA:19277]"}
{"concept_id": "C2248678", "aliases": [], "types": ["T044"], "canonical_name": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]"}
{"concept_id": "C2248679", "aliases": ["telomere complex location"], "types": ["T026"], "canonical_name": "telomere complex"}
{"concept_id": "C2248680", "aliases": [], "types": ["T044"], "canonical_name": "demethylmenaquinone methyltransferase activity", "definition": "Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine. [PMID:1444716, PMID:9045837]"}
{"concept_id": "C2248681", "aliases": [], "types": ["T044"], "canonical_name": "cytidine kinase activity", "definition": "Catalysis of the reaction: ATP + cytidine = ADP + CMP. [PMID:211379]"}
{"concept_id": "C2248682", "aliases": ["acylphosphate:glycerol-3-phosphate acyltransferase activity", "acyl-phosphate:glycerol-3-phosphate acyltransferase activity", "acylphosphate glycerol-3-phosphate acyltransferase activity"], "types": ["T044"], "canonical_name": "acyl-phosphate glycerol-3-phosphate acyltransferase activity", "definition": "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate. [PMID:17308305]"}
{"concept_id": "C2248683", "aliases": ["F420-0 gamma-glutamyl ligase activity"], "types": ["T044"], "canonical_name": "coenzyme F420-0 gamma-glutamyl ligase activity", "definition": "Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. [PMID:17669425]"}
{"concept_id": "C2248684", "aliases": ["F420-2 alpha-glutamyl ligase activity"], "types": ["T044"], "canonical_name": "coenzyme F420-2 alpha-glutamyl ligase activity", "definition": "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate. [PMID:12909715]"}
{"concept_id": "C2248686", "aliases": ["cobalt-precorrin-6B C5-methyltransferase activity", "precorrin-6 methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7. [MetaCyc:RXN-8766]", "canonical_name": "cobalt-precorrin 6B C5-methyltransferase activity"}
{"concept_id": "C2248687", "aliases": [], "types": ["T044"], "canonical_name": "precorrin-6Y C5,15-methyltransferase (decarboxylating)"}
{"concept_id": "C2248688", "aliases": ["cobalt-precorrin 7 C15-methyltransferase activity"], "types": ["T044"], "canonical_name": "cobalt-precorrin-7 C15-methyltransferase activity", "definition": "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2. [MetaCyc:RXN-8767]"}
{"concept_id": "C2248689", "aliases": ["cobalt-precorrin 8X methylmutase activity", "cobalt-precorrin 8 methylmutase activity", "cobalt-precorrin-8X methylmutase activity"], "types": ["T044"], "canonical_name": "cobalt-precorrin-8 methylmutase activity", "definition": "Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate. [MetaCyc:RXN-8768]"}
{"concept_id": "C2248690", "aliases": ["cobalt-precorrin 5A acetaldehyde-lyase activity"], "types": ["T044"], "canonical_name": "cobalt-precorrin-5A acetaldehyde-lyase activity", "definition": "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde + H+. [RHEA:26281]"}
{"concept_id": "C2248691", "aliases": ["cobalt-precorrin 5B C1-methyltransferase activity"], "types": ["T044"], "canonical_name": "cobalt-precorrin-5B C1-methyltransferase activity", "definition": "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A. [MetaCyc:RXN-8764]"}
{"concept_id": "C2248692", "aliases": ["S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity", "cobalt-precorrin-2 C(20)-methyltransferase activity", "CbiL", "cobalt-factor II C20 methyltransferase activity"], "types": ["T044"], "canonical_name": "cobalt-factor II C20-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III. [EC:2.1.1.151]"}
{"concept_id": "C2248693", "aliases": ["cobalt-precorrin-3B C17-methyltransferase activity", "cobalt-precorrin 3 C17-methyltransferase activity"], "types": ["T044"], "canonical_name": "cobalt-precorrin-3 C17-methyltransferase activity", "definition": "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine. [MetaCyc:RXN-8761]"}
{"concept_id": "C2248694", "aliases": [], "types": ["T044"], "canonical_name": "cobalt-precorrin-3 methylase"}
{"concept_id": "C2248695", "aliases": [], "types": ["T044"], "canonical_name": "cobalt-precorrin-3 methyltransferase"}
{"concept_id": "C2248696", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, oxidizing metal ions with flavin as acceptor"}
{"concept_id": "C2248697", "aliases": ["cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity"], "types": ["T044"], "canonical_name": "cob(II)yrinic acid a,c-diamide reductase activity", "definition": "Catalysis of the reaction: 2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH(2). [RHEA:24300]"}
{"concept_id": "C2248698", "aliases": ["FldA", "(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity"], "types": ["T044"], "canonical_name": "cinnamoyl-CoA:phenyllactate CoA-transferase activity", "definition": "Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate. [EC:2.8.3.17, RHEA:15601]"}
{"concept_id": "C2248699", "aliases": [], "types": ["T044"], "canonical_name": "cinnamate reductase activity", "definition": "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+. [PMID:10849007]"}
{"concept_id": "C2248701", "aliases": ["cardiolipin synthetase 2 activity"], "types": ["T044"], "canonical_name": "cardiolipin synthase 2 activity"}
{"concept_id": "C2248702", "aliases": [], "types": ["T044"], "canonical_name": "diguanylate cyclase activity", "definition": "Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+). [EC:2.7.7.65, RHEA:24898]"}
{"concept_id": "C2248704", "aliases": ["6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity"], "types": ["T044"], "canonical_name": "enamidase activity", "definition": "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H(2)O = 2-formylglutarate + NH(4)(+). [EC:3.5.2.18, RHEA:17209]"}
{"concept_id": "C2248705", "aliases": ["beta-RFAP synthase activity"], "types": ["T044"], "canonical_name": "beta-ribofuranosylaminobenzene 5'-phosphate synthase activity", "definition": "Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate. [GOC:jl, PMID:12142414]"}
{"concept_id": "C2248706", "aliases": ["formate dehydrogenase (F420) activity"], "types": ["T044"], "canonical_name": "formate dehydrogenase (coenzyme F420) activity", "definition": "Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420. [PMID:3801411]"}
{"concept_id": "C2248707", "aliases": [], "types": ["T044"], "canonical_name": "glyceraldehyde oxidoreductase activity", "definition": "Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+). [PMID:10095793, RHEA:36047]"}
{"concept_id": "C2248708", "aliases": [], "types": ["T044"], "canonical_name": "glyceraldehyde dehydrogenase (NADP) activity", "definition": "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+. [EC:1.2.1.89]"}
{"concept_id": "C2248709", "aliases": ["D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity", "GAPOR", "glyceraldehyde-3-phosphate Fd oxidoreductase activity", "glyceraldehyde-3-phosphate ferredoxin reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin. [PMID:11265456, PMID:7721730, RHEA:24148]", "canonical_name": "glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity"}
{"concept_id": "C2248710", "aliases": ["D-glycerate 2-kinase activity"], "types": ["T044"], "canonical_name": "glycerate 2-kinase activity", "definition": "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP. [PMID:14413719, RHEA:27377]"}
{"concept_id": "C2248711", "aliases": ["glycine:oxygen oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "glycine oxidase activity", "definition": "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide. [EC:1.4.3.19]"}
{"concept_id": "C2248712", "aliases": ["HUMPI"], "types": ["T044"], "canonical_name": "hexulose-6-phosphate isomerase activity", "definition": "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate. [MetaCyc:R12-RXN, PMID:11839305]"}
{"concept_id": "C2248713", "aliases": [], "types": ["T044"], "canonical_name": "hexulose-6-phosphate synthase activity", "definition": "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate. [PMID:16075199]"}
{"concept_id": "C2248714", "aliases": ["hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity", "hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity", "hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H(2)O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H(+) + hydrogenobyrinate a,c-diamide + 2 phosphate. [EC:6.3.5.9, RHEA:12544]", "canonical_name": "CobB"}
{"concept_id": "C2248715", "aliases": [], "types": ["T044"], "canonical_name": "hydroxyneurosporene-O-methyltransferase activity", "definition": "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene. [PMID:12664193, PMID:12770713, PMID:7358679, RHEA:30903]"}
{"concept_id": "C2248716", "aliases": [], "types": ["T044"], "canonical_name": "imidazolone hydrolase activity", "definition": "Catalysis of the reaction: N-formimidoylglycine => H2O + imidazol-4-one. [PMID:27286964, RHEA:24935]"}
{"concept_id": "C2248717", "aliases": ["IOR", "3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)", "3-(indol-3-yl)pyruvate synthase (ferredoxin) activity", "indolepyruvate oxidoreductase activity"], "types": ["T044"], "canonical_name": "indolepyruvate ferredoxin oxidoreductase activity", "definition": "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin. [EC:1.2.7.8]"}
{"concept_id": "C2248718", "aliases": ["keto-acid formate lyase activity", "keto-acid formate-lyase activity"], "types": ["T044"], "canonical_name": "keto acid formate lyase activity", "definition": "Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate. [MetaCyc:KETOBUTFORMLY-RXN]"}
{"concept_id": "C2248719", "aliases": ["keto-acid formate acetyltransferase"], "types": ["T044"], "canonical_name": "keto-acid formate acetyltransferase"}
{"concept_id": "C2248720", "aliases": ["3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity", "2-oxoisovalerate ferredoxin reductase activity", "3-methyl-2-oxobutanoate synthase (ferredoxin) activity", "ketoisovalerate ferredoxin reductase activity", "VOR", "keto-valine-ferredoxin oxidoreductase activity", "2-ketoisovalerate ferredoxin reductase activity", "ketoisovalerate oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin. [EC:1.2.7.7]", "canonical_name": "3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)"}
{"concept_id": "C2248721", "aliases": [], "types": ["T044"], "canonical_name": "branched-chain ketoacid ferredoxin reductase activity"}
{"concept_id": "C2248722", "aliases": [], "types": ["T044"], "canonical_name": "branched-chain oxo acid ferredoxin reductase activity"}
{"concept_id": "C2248723", "aliases": [], "types": ["T044"], "canonical_name": "lyso-ornithine lipid acyltransferase activity", "definition": "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]. [PMID:15341653]"}
{"concept_id": "C2248725", "aliases": ["ornithine-acyl[acyl carrier protein] N-acyltransferase activity", "L-ornithine N(alpha)-acyltransferase"], "types": ["T044"], "canonical_name": "ornithine-acyl [acyl carrier protein] N-acyltransferase activity", "definition": "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids. [PMID:15341653, RHEA:20633]"}
{"concept_id": "C2248726", "aliases": [], "types": ["T044"], "canonical_name": "phosphate:acyl-[acyl carrier protein] acyltransferase activity", "definition": "Catalysis of the reaction: a fatty acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]. [RHEA:42292]"}
{"concept_id": "C2248727", "aliases": ["phosphatidylinositol 4-phosphate phosphatase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol-4-phosphate phosphatase activity", "definition": "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate. [PMID:10224048]"}
{"concept_id": "C2248728", "aliases": ["phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate. [PMID:10806194, PMID:16607019]"}
{"concept_id": "C2248729", "aliases": [], "types": ["T044"], "canonical_name": "phospholactate guanylyltransferase activity", "definition": "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate. [PMID:18260642, RHEA:63424]"}
{"concept_id": "C2248730", "aliases": ["GART 2", "5'-phosphoribosylglycinamide transformylase 2", "formate-dependent GAR transformylase activity", "GAR transformylase 2"], "types": ["T044"], "canonical_name": "phosphoribosylglycinamide formyltransferase 2 activity", "definition": "Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate. [EC:2.1.2.2, PMID:8117714]"}
{"concept_id": "C2248731", "aliases": ["O-phosphoseryl-tRNA(Cys) synthetase activity", "phosphoserine-tRNACys ligase activity", "SepRS", "phosphoserine--tRNA(Cys) ligase activity"], "types": ["T045"], "canonical_name": "phosphoserine-tRNA(Cys) ligase activity", "definition": "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys). [PMID:17110438, RHEA:25678]"}
{"concept_id": "C2248732", "aliases": ["(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)", "(2R)-O-phospho-3-sulfolactate sulfo-lyase activity", "PSL synthase activity", "(2R)-phospho-3-sulfolactate synthase activity"], "types": ["T044"], "canonical_name": "phosphosulfolactate synthase activity", "definition": "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite. [EC:4.4.1.19, RHEA:22784]"}
{"concept_id": "C2248733", "aliases": ["precorrin-3X synthase activity", "CobG", "precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)"], "types": ["T044"], "canonical_name": "precorrin-3B synthase activity", "definition": "Catalysis of the reaction: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B. [EC:1.14.13.83, RHEA:17293]"}
{"concept_id": "C2248734", "aliases": ["CobF", "S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)", "precorrin-6X synthase (deacetylating) activity"], "types": ["T044"], "canonical_name": "precorrin-6A synthase (deacetylating) activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H(+) + precorrin-6X. [EC:2.1.1.152, RHEA:18261]"}
{"concept_id": "C2248735", "aliases": [], "types": ["T044"], "canonical_name": "propionyl-CoA dehydrogenase activity", "definition": "Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA. [PMID:12603323]"}
{"concept_id": "C2248736", "aliases": ["propionyl-CoA:succinate CoA transferase activity", "propionyl-CoA succinate CoA-transferase activity"], "types": ["T044"], "canonical_name": "propionyl-CoA:succinate CoA-transferase activity", "definition": "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate. [PMID:10769117]"}
{"concept_id": "C2248737", "aliases": ["RNase M5 activity", "5S ribosomal maturation nuclease activity", "5S ribosomal RNA maturation endonuclease activity"], "types": ["T045"], "canonical_name": "ribonuclease M5 activity", "definition": "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor. [PMID:402365]"}
{"concept_id": "C2248738", "aliases": [], "types": ["T044"], "canonical_name": "spheroidene monooxygenase activity", "definition": "Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O. [PMID:16086104, PMID:16158287]"}
{"concept_id": "C2248739", "aliases": ["AstD", "SGSD", "AruD", "succinylglutamic semialdehyde dehydrogenase activity", "N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity", "N-succinylglutamate 5-semialdehyde dehydrogenase activity", "succinyl glutamate-semialdehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "succinylglutamate-semialdehyde dehydrogenase activity", "definition": "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H(2)O + NAD(+) = N-succinyl-L-glutamate + 2 H(+) + NADH. [EC:1.2.1.71, RHEA:10812]"}
{"concept_id": "C2248740", "aliases": ["succinylornithine aminotransferase activity"], "types": ["T044"], "canonical_name": "succinylornithine aminotransferase activity"}
{"concept_id": "C2248741", "aliases": ["tRNA (adenine-57, 58-N1-) methyltransferase activity", "tRNA (adenine-57, 58 N1-) methyltransferase activity", "TrmI"], "types": ["T045"], "canonical_name": "tRNA (adenine-57, 58-N(1)-) methyltransferase activity", "definition": "Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA. [PMID:14739239]"}
{"concept_id": "C2248742", "aliases": [], "types": ["T045"], "canonical_name": "tRNA (m1A) MTase"}
{"concept_id": "C2248743", "aliases": [], "types": ["T045"], "canonical_name": "tRNA 2-selenouridine synthase activity", "definition": "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA). [PMID:14594807, RHEA:42716]"}
{"concept_id": "C2248744", "aliases": [], "types": ["T044"], "canonical_name": "thiol-driven fumarate reductase activity", "definition": "Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide. [PMID:2509466]"}
{"concept_id": "C2248745", "aliases": ["thiosulphate dehydrogenase (quinone) activity", "TQO", "thiosulphate:quinone oxidoreductase activity", "thiosulfate oxidoreductase, tetrathionate-forming activity", "thiosulfate:quinone oxidoreductase activity", "DoxD", "DoxA", "thiosulfate:6-decylubiquinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "thiosulfate dehydrogenase (quinone) activity", "definition": "Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate. [EC:1.8.5.2, RHEA:10936]"}
{"concept_id": "C2248746", "aliases": ["decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity", "trans-2,cis-3-decenoyl-ACP isomerase activity", "trans-2-decenoyl-ACP isomerase activity", "trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity", "trans-2, cis-3 decenoyl-ACP isomerase activity", "trans-2-cis-3-decenoyl-ACP isomerase activity"], "types": ["T044"], "canonical_name": "trans-2-decenoyl-acyl-carrier-protein isomerase activity", "definition": "Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]. [RHEA:23568]"}
{"concept_id": "C2248748", "aliases": [], "types": ["T044"], "canonical_name": "dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity"}
{"concept_id": "C2248750", "aliases": [], "types": ["T044"], "canonical_name": "monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity"}
{"concept_id": "C2248751", "aliases": [], "types": ["T044"], "canonical_name": "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity"}
{"concept_id": "C2248754", "aliases": ["xanthinase activity"], "types": ["T044"], "canonical_name": "xanthine hydrolase activity", "definition": "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate. [MetaCyc:R127-RXN, PMID:13278326]"}
{"concept_id": "C2248755", "aliases": ["ValDH"], "types": ["T044"], "canonical_name": "valine dehydrogenase (NAD) activity", "definition": "Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH. [PMID:10612726, PMID:2803248]"}
{"concept_id": "C2248756", "aliases": ["EptB"], "types": ["T044"], "canonical_name": "phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity", "definition": "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol. [PMID:15795227]"}
{"concept_id": "C2248757", "aliases": [], "types": ["T044"], "canonical_name": "phosphoethanolamine transferase"}
{"concept_id": "C2248758", "aliases": ["lipid A 1-phosphomethyltransferase activity", "lipid A phosphomethyltransferase activity", "LmtA"], "types": ["T044"], "canonical_name": "lipid A phosphate methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A. [PMID:15994324]"}
{"concept_id": "C2248759", "aliases": [], "types": ["T044"], "canonical_name": "lipid A methyltransferase"}
{"concept_id": "C2248760", "aliases": ["branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity", "branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity", "BCAT"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine. [PMID:12670965]", "canonical_name": "branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity"}
{"concept_id": "C2248761", "aliases": ["lactate 2-kinase activity"], "types": ["T044"], "canonical_name": "(S)-lactate 2-kinase activity", "definition": "Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP. [PMID:11535063]"}
{"concept_id": "C2248762", "aliases": ["3-deoxy-D-manno-octulosonic-acid transferase activity", "kdtA", "WaaA"], "types": ["T044"], "canonical_name": "Kdo transferase activity", "definition": "Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP. [PMID:1577828, PMID:2033061, PMID:9195966]"}
{"concept_id": "C2248763", "aliases": ["ADP:D-glucose 6-phosphotransferase activity", "ADP-dependent glucokinase activity"], "types": ["T044"], "canonical_name": "ADP-specific glucokinase activity", "definition": "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate. [EC:2.7.1.147]"}
{"concept_id": "C2248764", "aliases": ["ADP:D-fructose-6-phosphate 1-phosphotransferase activity", "ADP-dependent phosphofructokinase activity", "ADP-Pfk activity", "ADP-6-phosphofructokinase activity"], "types": ["T044"], "canonical_name": "ADP-specific phosphofructokinase activity", "definition": "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate. [EC:2.7.1.146]"}
{"concept_id": "C2248765", "aliases": ["DNA polymerase III, proof-reading subcomplex", "DNA polymerase III, proof-reading complex location", "DNA polymerase III, proof-reading subcomplex location", "DNA polymerase III, proofreading complex location", "DNA polymerase III, proof-reading complex", "DNA polymerase III, proofreading subcomplex", "DNA polymerase III, proofreading subcomplex location"], "types": ["T026"], "canonical_name": "DNA polymerase III, proofreading complex", "definition": "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity. [PMID:16973612, Wikipedia:Pol_III]"}
{"concept_id": "C2248766", "aliases": ["DNA polymerase III, DnaX complex", "DNA polymerase III, DnaX subcomplex location", "DNA polymerase III, DnaX subcomplex", "DNA polymerase III, DnaX complex location", "DNA polymerase III, clamp loader complex location"], "types": ["T026"], "canonical_name": "DNA polymerase III, clamp loader complex", "definition": "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. [PMID:12940977]"}
{"concept_id": "C2248767", "aliases": ["clamp loader complex location"], "types": ["T026"], "canonical_name": "clamp loader complex"}
{"concept_id": "C2248768", "aliases": ["DNA polymerase III, DnaX complex, chi/psi subcomplex location", "DNA polymerase III, DnaX complex, chi/psi subcomplex", "DNA polymerase III, clamp loader chi/psi subcomplex location"], "types": ["T026"], "canonical_name": "DNA polymerase III, clamp loader chi/psi subcomplex", "definition": "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB). [PMID:12940977]"}
{"concept_id": "C2248771", "aliases": ["ERF2", "Ras palmitoyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins. [PMID:16000296]", "canonical_name": "Ras protein acyltransferase activity"}
{"concept_id": "C2248772", "aliases": [], "types": ["T044"], "canonical_name": "DHHC cysteine-rich domain-containing protein ERF2"}
{"concept_id": "C2248773", "aliases": [], "types": ["T044"], "canonical_name": "palmitoyltransferase ERF2"}
{"concept_id": "C2248774", "aliases": ["RecFOR complex location"], "types": ["T026"], "canonical_name": "RecFOR complex", "definition": "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair. [PMID:12769856]"}
{"concept_id": "C2248776", "aliases": ["monomethylamine:corrinoid methyltransferase activity", "MtmB", "MMAMT"], "types": ["T044"], "canonical_name": "monomethylamine methyltransferase activity", "definition": "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3. [PMID:9195968]"}
{"concept_id": "C2248777", "aliases": ["methanol: coenzyme M methyltransferase complex", "methanol:CoM methyltransferase complex location", "methanol-coenzyme M methyltransferase complex", "methanol: CoM methyltransferase complex", "methanol:coenzyme M methyltransferase complex", "methanol:CoM methyltransferase complex", "methanol: coenzyme M methyltransferase complex location", "methanol-coenzyme M methyltransferase complex location", "methanol-CoM methyltransferase complex location", "methanol:coenzyme M methyltransferase complex location", "methanol: CoM methyltransferase complex location"], "types": ["T026"], "canonical_name": "methanol-CoM methyltransferase complex", "definition": "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol. [PMID:9363780]"}
{"concept_id": "C2248778", "aliases": ["small conductance mechanosensitive ion channel", "MscS", "cyclic nucleotide regulated mechanosensitive ion channel", "cyclic nucleotide-gated mechanosensitive ion channel activity", "cyclic nucleotide-regulated mechanosensitive ion channel"], "types": ["T044"], "definition": "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. [GOC:jl, PMID:22206667]", "canonical_name": "cyclic nucleotide gated mechanosensitive ion channel activity"}
{"concept_id": "C2248779", "aliases": [], "types": ["T044"], "canonical_name": "cyclic nucleotide-regulated small mechanosensitive ion channel"}
{"concept_id": "C2248780", "aliases": ["cyclic nucleotide-activated ion channel activity", "cyclic nucleotide activated ion channel activity", "cyclic nucleotide gated ion channel activity"], "types": ["T044"], "canonical_name": "cyclic nucleotide-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. [GOC:jl]"}
{"concept_id": "C2248781", "aliases": ["anti-anti-sigma factor activity"], "types": ["T045"], "canonical_name": "anti-sigma factor antagonist activity", "definition": "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity. [GOC:jl, GOC:txnOH, PMID:15576799]"}
{"concept_id": "C2248782", "aliases": ["AOTC", "carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity", "acetylornithine transcarbamylase activity", "N-acetylornithine transcarbamylase activity", "carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity"], "types": ["T044"], "canonical_name": "N-acetylornithine carbamoyltransferase activity", "definition": "Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H(+) + phosphate. [EC:2.1.3.9, RHEA:18609]"}
{"concept_id": "C2248783", "aliases": ["arginine/ornithine antiporter activity", "ArcD", "arginine:ornithine antiporter activity"], "types": ["T044"], "definition": "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out). [GOC:jl, PMID:17110979]", "canonical_name": "arginine-ornithine antiporter activity"}
{"concept_id": "C2248785", "aliases": ["cyanophycin synthetase activity"], "types": ["T044"], "definition": "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer). [EC:6.3.2.29, EC:6.3.2.30, GOC:jl]", "canonical_name": "cphA"}
{"concept_id": "C2248786", "aliases": ["agmatine/putrescine antiporter activity", "agmatine-putrescine antiporter activity"], "types": ["T044"], "canonical_name": "agmatine:putrescine antiporter activity", "definition": "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out). [GOC:jl, PMID:17028272]"}
{"concept_id": "C2248787", "aliases": ["lysine:cadaverine antiporter activity", "lysine/cadaverine antiporter activity", "AdiC", "arginine-agmatine exchange transporter activity", "cadaverine:lysine antiporter activity", "lysine-cadaverine antiporter activity", "arginine-agmatine antiporter activity", "arginine/agmatine antiporter activity"], "types": ["T044"], "canonical_name": "arginine:agmatine antiporter activity", "definition": "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out). [GOC:jl, PMID:10986235, TC:2.A.3.2.2]"}
{"concept_id": "C2248788", "aliases": ["HpaI", "HpcH", "HHED aldolase activity", "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity"], "types": ["T044"], "canonical_name": "4-hydroxy-2-ketopimelate aldolase activity", "definition": "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate. [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN]"}
{"concept_id": "C2248789", "aliases": ["indoleacetamide hydrolase activity", "indole acetamide hydrolase activity", "Tms2", "IAH", "IaaH"], "types": ["T044"], "definition": "Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA. [GOC:jl, RHEA:34371]", "canonical_name": "indole-3-acetamide hydrolase activity"}
{"concept_id": "C2248790", "aliases": [], "types": ["T044"], "canonical_name": "methionine transmembrane transporter activity", "definition": "Enables the transfer of methionine from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C2248791", "aliases": ["AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)", "AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)", "thioredoxin-dependent 5'-adenylylsulfate reductase activity"], "types": ["T044"], "canonical_name": "adenylyl-sulfate reductase (thioredoxin) activity", "definition": "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin. [EC:1.8.4.10]"}
{"concept_id": "C2248792", "aliases": ["TgtA", "archaeal tRNA-guanine transglycosylase activity", "archaeosine tRNA-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "7-cyano-7-deazaguanine tRNA-ribosyltransferase activity", "definition": "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine. [PMID:16407303, PMID:7748953]"}
{"concept_id": "C2248794", "aliases": [], "types": ["T044"], "canonical_name": "alpha-aminoadipate acetyltransferase activity", "definition": "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A. [PMID:10613839, PMID:12925802, PMID:29053735]"}
{"concept_id": "C2248796", "aliases": ["N-acetyl-aminoadipate semialdehyde dehydrogenase activity", "ArgC", "AGPR", "N-acetyl-alpha-glutamyl-phosphate reductase activity", "LysY"], "types": ["T044"], "canonical_name": "N-acetyl-gamma-aminoadipyl-phosphate reductase activity", "definition": "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH. [MetaCyc:RXN-5183]"}
{"concept_id": "C2248797", "aliases": ["NAGSA dehydrogenase activity"], "types": ["T044"], "canonical_name": "NAGSA dehydrogenase activity"}
{"concept_id": "C2248798", "aliases": ["PIPOX", "delta1-piperideine-6-carboxylate dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. [MetaCyc:RXN-8162, PMID:16237033]", "canonical_name": "AmaB"}
{"concept_id": "C2248800", "aliases": ["NifJ", "pyruvate:flavodoxin oxidoreductase activity"], "types": ["T044"], "canonical_name": "pyruvate-flavodoxin oxidoreductase activity", "definition": "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin. [PMID:6352705]"}
{"concept_id": "C2248801", "aliases": [], "types": ["T044"], "canonical_name": "E-1 enolase-phosphatase"}
{"concept_id": "C2248802", "aliases": ["TdcE", "KFL"], "types": ["T044"], "canonical_name": "2-ketobutyrate formate-lyase activity", "definition": "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate. [PMID:9484901, RHEA:28054]"}
{"concept_id": "C2248803", "aliases": ["DtaAS", "D-TA", "D-allo-threonine aldolase activity", "D-allo-TA"], "types": ["T044"], "canonical_name": "D-threonine aldolase activity", "definition": "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde. [MetaCyc:4.1.2.42-RXN, PMID:9642221]"}
{"concept_id": "C2248804", "aliases": [], "types": ["T044"], "canonical_name": "low-specificity D-threonine aldolase"}
{"concept_id": "C2248805", "aliases": ["AgaI", "galactosamine-6-phosphate deaminase activity"], "types": ["T044"], "canonical_name": "galactosamine-6-phosphate isomerase activity", "definition": "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3. [PMID:10931310]"}
{"concept_id": "C2248806", "aliases": ["glyceraldehyde-3-phosphate dehydrogenase (NAD) activity", "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)", "glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity", "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity"], "types": ["T044"], "canonical_name": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity", "definition": "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+. [PMID:9497334]"}
{"concept_id": "C2248807", "aliases": ["glcA", "glycolic acid transmembrane transporter activity", "hydroxyacetic acid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "glycolate transmembrane transporter activity", "definition": "Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA). [GOC:jl, RHEA:29447]"}
{"concept_id": "C2248808", "aliases": [], "types": ["T044"], "canonical_name": "glycolate permease"}
{"concept_id": "C2248809", "aliases": ["crotonyl-CoA reductase activity", "CCR"], "types": ["T044"], "definition": "Catalysis of the reduction of crotonyl-CoA to butyryl-CoA. [InterPro:IPR010085, PMID:11162231]", "canonical_name": "crotonyl-coenzyme A reductase activity"}
{"concept_id": "C2248810", "aliases": ["mesaconyl-CoA hydratase activity", "beta-methylmalyl-CoA dehydratase activity", "mch"], "types": ["T044"], "definition": "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA. [PMID:16856935, PMID:16856937]", "canonical_name": "mesaconyl-coenzyme A hydratase activity"}
{"concept_id": "C2248811", "aliases": ["Na+:malate symporter activity", "malate:sodium cotransporter activity", "sodium-dependent malate transporter", "malate Na(+) symporter activity", "sodium/malate symporter activity", "sodium:malate symporter activity", "Na(+)-malate symporter activity", "malate-sodium symporter activity", "malate/sodium cotransporter activity", "malate:Na+ symporter activity", "malate/sodium symporter activity"], "types": ["T044"], "canonical_name": "malate:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in). [GOC:jl, PMID:10903309]"}
{"concept_id": "C2248813", "aliases": ["MleS"], "types": ["T044"], "canonical_name": "malolactic enzyme activity", "definition": "Catalysis of the reaction: malate + H+ = L-lactate + CO2. [MetaCyc:RXN8E-5623, PMID:3139053]"}
{"concept_id": "C2248815", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of carboxysome", "definition": "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO(2). [GOC:jl, PMID:28934381]"}
{"concept_id": "C2248816", "aliases": ["Na+:melibiose symporter activity", "sodium:melibiose symporter activity", "melibiose/Na+ symporter activity", "melibiose-sodium symporter activity", "sodium/melibiose symporter activity", "melibiose-Na+ symporter activity", "Na+/melibiose symporter activity", "melibiose:Na+ symporter activity", "Na+-melibiose symporter activity", "Na+ (Li+)/melibiose symporter activity", "sodium-melibiose symporter activity", "MelB", "melibiose/sodium symporter activity"], "types": ["T044"], "canonical_name": "melibiose:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in). [PMID:1970646]"}
{"concept_id": "C2248817", "aliases": [], "types": ["T044"], "canonical_name": "melibiose carrier protein"}
{"concept_id": "C2248818", "aliases": [], "types": ["T044"], "canonical_name": "thiomethylgalactoside permease II"}
{"concept_id": "C2248819", "aliases": ["2,3-dGGGPS", "DGGGP synthase activity", "DGGGPS", "UbiA"], "types": ["T044"], "canonical_name": "(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity", "definition": "Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate. [PMID:15356000, PMID:16494480]"}
{"concept_id": "C2248820", "aliases": ["(S)-3-O-geranylgeranylglycerylphosphate synthase activity", "(S)-GGGP synthase activity", "GGGPS", "GGGP synthase activity"], "types": ["T044"], "canonical_name": "(S)-3-O-geranylgeranylglyceryl phosphate synthase activity", "definition": "Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate. [PMID:12801917, PMID:17253090, PMID:8408023]"}
{"concept_id": "C2248821", "aliases": ["chondroitinase", "galactose-6-sulfate sulfatase activity", "N-acetylgalactosamine 6-sulfatase activity", "acetylgalactosamine 6-sulfatase activity", "N-acetylgalactosamine-6-sulfate sulfatase activity", "N-acetylgalactosamine-6-sulfatase activity"], "types": ["T044"], "definition": "Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. [EC:3.1.6.4]", "canonical_name": "N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity"}
{"concept_id": "C2248822", "aliases": ["chondroitinsulfatase", "chondroitin sulfatase"], "types": ["T044"], "canonical_name": "chondroitinsulfatase activity"}
{"concept_id": "C2248823", "aliases": ["triosephosphate dehydrogenase (NAD(P)+)", "triosephosphate dehydrogenase (NAD(P))", "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity", "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)", "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+. [EC:1.2.1.59]", "canonical_name": "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity"}
{"concept_id": "C2248824", "aliases": ["lactaldehyde dehydrogenase (NADP+)", "Gre2", "lactaldehyde:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "methylglyoxal reductase (NADPH-dependent) activity", "definition": "Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+. [EC:1.1.1.283]"}
{"concept_id": "C2248825", "aliases": ["cation-acetate symporter activity", "ActP", "cation/acetate symporter activity", "acetate/cation symporter activity", "acetate:cation symporter activity", "cation:acetate symporter activity"], "types": ["T044"], "definition": "Enables the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in). [GOC:jl, PMID:14563880]", "canonical_name": "acetate-cation symporter activity"}
{"concept_id": "C2248826", "aliases": [], "types": ["T044"], "canonical_name": "acetate permease"}
{"concept_id": "C2248827", "aliases": ["Pat"], "types": ["T044"], "canonical_name": "protein acetyltransferase activity"}
{"concept_id": "C2248828", "aliases": ["Pat enzyme"], "types": ["T044"], "canonical_name": "acetyl-CoA synthetase acetyltransferase activity", "definition": "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate. [PMID:15236963]"}
{"concept_id": "C2248829", "aliases": ["cyclodextrin glycosyltransferase", "CGTase", "BMA", "alpha-cyclodextrin glycosyltransferase", "beta-cyclodextrin glycosyltransferase", "cyclomaltodextrin glucanotransferase activity", "Bacillus macerans amylase", "cyclodextrin glucanotransferase"], "types": ["T044"], "definition": "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond. [EC:2.4.1.19]", "canonical_name": "1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)"}
{"concept_id": "C2248830", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1,4-glucan 4-glycosyltransferase, cyclizing"}
{"concept_id": "C2248831", "aliases": [], "types": ["T044"], "canonical_name": "alpha-cyclodextrin glucanotransferase"}
{"concept_id": "C2248832", "aliases": [], "types": ["T044"], "canonical_name": "beta-cyclodextrin glucanotransferase"}
{"concept_id": "C2248833", "aliases": [], "types": ["T044"], "canonical_name": "cyclomaltodextrin glucotransferase"}
{"concept_id": "C2248834", "aliases": [], "types": ["T044"], "canonical_name": "cyclomaltodextrin glycosyltransferase"}
{"concept_id": "C2248835", "aliases": [], "types": ["T044"], "canonical_name": "gamma-cyclodextrin glycosyltransferase"}
{"concept_id": "C2248836", "aliases": [], "types": ["T044"], "canonical_name": "konchizaimu"}
{"concept_id": "C2248837", "aliases": [], "types": ["T044"], "canonical_name": "neutral-cyclodextrin glycosyltransferase"}
{"concept_id": "C2248838", "aliases": ["exo-1,6-alpha-glucosidase activity", "glucan-1,6-alpha-glucosidase activity", "glucan alpha-1,6-D-glucohydrolase activity", "glucodextranase activity"], "types": ["T044"], "canonical_name": "glucan 1,6-alpha-glucosidase activity", "definition": "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides. [EC:3.2.1.70]"}
{"concept_id": "C2248839", "aliases": [], "types": ["T044"], "canonical_name": "exo-1,6-beta-glucosidase"}
{"concept_id": "C2248840", "aliases": [], "types": ["T044"], "canonical_name": "glucodextrinase"}
{"concept_id": "C2248841", "aliases": ["maltogenic alpha-amylase activity", "glucan-1,4-alpha-maltohydrolase activity", "1,4-alpha-D-glucan alpha-maltohydrolase activity"], "types": ["T044"], "canonical_name": "glucan 1,4-alpha-maltohydrolase activity", "definition": "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains. [EC:3.2.1.133]"}
{"concept_id": "C2248842", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host morphology or physiology"}
{"concept_id": "C2248844", "aliases": ["negative regulation of metabolic activity during hibernation", "down-regulation of metabolic activity during hibernation", "inhibition of metabolic activity during hibernation", "downregulation of metabolic activity during hibernation", "down regulation of metabolic activity during hibernation"], "types": ["T040"], "canonical_name": "negative regulation of metabolic activity involved in hibernation", "definition": "The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation. [GOC:jl, Wikipedia:Hibernation]"}
{"concept_id": "C2248848", "aliases": [], "types": ["T043"], "canonical_name": "main pathways of carbohydrate metabolic process"}
{"concept_id": "C2248849", "aliases": [], "types": ["T043"], "canonical_name": "main pathways of carbohydrate metabolism"}
{"concept_id": "C2248856", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription by glucose"}
{"concept_id": "C2248858", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nitric oxide biosynthetic process"}
{"concept_id": "C2248859", "aliases": [], "types": ["T045"], "canonical_name": "activation of viral genome replication"}
{"concept_id": "C2248860", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of viral genome replication"}
{"concept_id": "C2248863", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of viral genome replication"}
{"concept_id": "C2248889", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of innate immune response"}
{"concept_id": "C2248891", "aliases": ["GEM domain"], "types": ["T026"], "canonical_name": "glycolipid-enriched membrane domain"}
{"concept_id": "C2248898", "aliases": ["down-regulation of meiotic recombination", "down regulation of meiotic recombination", "suppression of meiotic recombination", "downregulation of meiotic recombination"], "types": ["T043"], "canonical_name": "negative regulation of reciprocal meiotic recombination", "definition": "Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2248899", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of meiotic recombination"}
{"concept_id": "C2248912", "aliases": [], "types": ["T044"], "canonical_name": "alginase I"}
{"concept_id": "C2248914", "aliases": [], "types": ["T044"], "canonical_name": "alginate lyase I activity"}
{"concept_id": "C2248916", "aliases": [], "types": ["T044"], "canonical_name": "poly(mana) alginate lyase activity"}
{"concept_id": "C2248921", "aliases": [], "types": ["T044"], "canonical_name": "peptidase B"}
{"concept_id": "C2248932", "aliases": [], "types": ["T043"], "canonical_name": "activation of FasL biosynthetic process"}
{"concept_id": "C2248933", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of FasL biosynthetic process"}
{"concept_id": "C2248936", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of FasL biosynthetic process"}
{"concept_id": "C2248937", "aliases": [], "types": ["T043"], "canonical_name": "activation of CD4 biosynthetic process"}
{"concept_id": "C2248938", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of CD4 biosynthetic process"}
{"concept_id": "C2248941", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of CD4 biosynthetic process"}
{"concept_id": "C2248942", "aliases": ["proton-transporting F-type ATPase complex location"], "types": ["T026"], "canonical_name": "proton-transporting F-type ATPase complex"}
{"concept_id": "C2248964", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of MHC class I biosynthetic process"}
{"concept_id": "C2248965", "aliases": [], "types": ["T044"], "canonical_name": "activation of MHC class I biosynthetic process"}
{"concept_id": "C2248966", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of MHC class I biosynthetic process"}
{"concept_id": "C2248969", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of MHC class II biosynthetic process"}
{"concept_id": "C2248970", "aliases": [], "types": ["T044"], "canonical_name": "activation of MHC class II biosynthetic process"}
{"concept_id": "C2248971", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of MHC class II biosynthetic process"}
{"concept_id": "C2249092", "aliases": [], "types": ["T043"], "canonical_name": "activation of nitric oxide biosynthetic process"}
{"concept_id": "C2249093", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of nitric oxide biosynthetic process"}
{"concept_id": "C2249100", "aliases": ["male courtship behaviour, veined wing generated song production", "male courtship behavior, song production", "male courtship behaviour, song production"], "types": ["T054"], "canonical_name": "male courtship behavior, veined wing generated song production", "definition": "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song. [GOC:mtg_sensu, PMID:11092827]"}
{"concept_id": "C2249102", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of female receptivity, post-mating"}
{"concept_id": "C2249103", "aliases": [], "types": ["T044"], "canonical_name": "lycopene cyclase"}
{"concept_id": "C2249107", "aliases": [], "types": ["T043"], "canonical_name": "R8 cell development", "definition": "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium. [PMID:11880339]"}
{"concept_id": "C2249108", "aliases": [], "types": ["T043"], "canonical_name": "R7 cell development", "definition": "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium. [PMID:11880339]"}
{"concept_id": "C2249109", "aliases": [], "types": ["T042"], "canonical_name": "R8 cell spacing in compound eye"}
{"concept_id": "C2249110", "aliases": ["down regulation of R8 spacing", "downregulation of R8 spacing", "down-regulation of R8 spacing"], "types": ["T042"], "canonical_name": "negative regulation of R8 cell spacing in compound eye", "definition": "Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye. [GOC:dph, GOC:tb, PMID:11880339]"}
{"concept_id": "C2249111", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of R8 spacing"}
{"concept_id": "C2249112", "aliases": [], "types": ["T044"], "canonical_name": "beta-galactose oxidase activity"}
{"concept_id": "C2249116", "aliases": ["sesquiterpene cyclase activity"], "types": ["T044"], "canonical_name": "sesquiterpene cyclase activity"}
{"concept_id": "C2249161", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cholesterol biosynthetic process"}
{"concept_id": "C2249162", "aliases": [], "types": ["T043"], "canonical_name": "activation of cholesterol biosynthetic process"}
{"concept_id": "C2249163", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cholesterol biosynthetic process"}
{"concept_id": "C2249165", "aliases": [], "types": ["T044"], "canonical_name": "(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)"}
{"concept_id": "C2249170", "aliases": ["tyrase activity", "TAL activity", "L-tyrosine ammonia-lyase activity"], "types": ["T044"], "canonical_name": "tyrosine ammonia-lyase activity", "definition": "Catalysis of the reaction: L-tyrosine = NH(4)(+) + trans-4-coumarate. [RHEA:24906]"}
{"concept_id": "C2249176", "aliases": [], "types": ["T044"], "canonical_name": "AtNCED3"}
{"concept_id": "C2249178", "aliases": [], "types": ["T044"], "canonical_name": "PvNCED1"}
{"concept_id": "C2249207", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of imaginal disc growth"}
{"concept_id": "C2249208", "aliases": [], "types": ["T040"], "canonical_name": "activation of imaginal disc growth"}
{"concept_id": "C2249209", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of imaginal disc growth"}
{"concept_id": "C2249212", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of B cell differentiation"}
{"concept_id": "C2249213", "aliases": [], "types": ["T043"], "canonical_name": "activation of B cell differentiation"}
{"concept_id": "C2249214", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of B cell differentiation"}
{"concept_id": "C2249217", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell differentiation"}
{"concept_id": "C2249218", "aliases": [], "types": ["T043"], "canonical_name": "activation of T cell differentiation"}
{"concept_id": "C2249219", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T cell differentiation"}
{"concept_id": "C2249222", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytotoxic T cell differentiation"}
{"concept_id": "C2249223", "aliases": [], "types": ["T043"], "canonical_name": "activation of cytotoxic T cell differentiation"}
{"concept_id": "C2249224", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cytotoxic T cell differentiation"}
{"concept_id": "C2249227", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gamma-delta T cell differentiation"}
{"concept_id": "C2249228", "aliases": [], "types": ["T043"], "canonical_name": "activation of gamma-delta T cell differentiation"}
{"concept_id": "C2249229", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of gamma-delta T cell differentiation"}
{"concept_id": "C2249232", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of regulatory T cell differentiation"}
{"concept_id": "C2249233", "aliases": [], "types": ["T043"], "canonical_name": "activation of regulatory T cell differentiation"}
{"concept_id": "C2249234", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of regulatory T cell differentiation"}
{"concept_id": "C2249237", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cumulus cell differentiation"}
{"concept_id": "C2249238", "aliases": [], "types": ["T043"], "canonical_name": "activation of cumulus cell differentiation"}
{"concept_id": "C2249239", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cumulus cell differentiation"}
{"concept_id": "C2249242", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell differentiation"}
{"concept_id": "C2249243", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell differentiation"}
{"concept_id": "C2249246", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fat cell differentiation"}
{"concept_id": "C2249247", "aliases": [], "types": ["T043"], "canonical_name": "activation of fat cell differentiation"}
{"concept_id": "C2249248", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of fat cell differentiation"}
{"concept_id": "C2249251", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelial cell differentiation"}
{"concept_id": "C2249252", "aliases": [], "types": ["T043"], "canonical_name": "activation of endothelial cell differentiation"}
{"concept_id": "C2249253", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of endothelial cell differentiation"}
{"concept_id": "C2249256", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of epidermal cell differentiation"}
{"concept_id": "C2249257", "aliases": [], "types": ["T043"], "canonical_name": "activation of epidermal cell differentiation"}
{"concept_id": "C2249258", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of epidermal cell differentiation"}
{"concept_id": "C2249261", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of auditory receptor cell differentiation"}
{"concept_id": "C2249262", "aliases": [], "types": ["T043"], "canonical_name": "activation of auditory receptor cell differentiation"}
{"concept_id": "C2249263", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of auditory receptor cell differentiation"}
{"concept_id": "C2249266", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hemocyte differentiation"}
{"concept_id": "C2249267", "aliases": [], "types": ["T043"], "canonical_name": "activation of hemocyte differentiation"}
{"concept_id": "C2249268", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of hemocyte differentiation"}
{"concept_id": "C2249271", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of plasmatocyte differentiation"}
{"concept_id": "C2249272", "aliases": [], "types": ["T043"], "canonical_name": "activation of plasmatocyte differentiation"}
{"concept_id": "C2249273", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of plasmatocyte differentiation"}
{"concept_id": "C2249276", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of keratinocyte differentiation"}
{"concept_id": "C2249277", "aliases": [], "types": ["T043"], "canonical_name": "activation of keratinocyte differentiation"}
{"concept_id": "C2249278", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of keratinocyte differentiation"}
{"concept_id": "C2249281", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lymphocyte differentiation"}
{"concept_id": "C2249282", "aliases": [], "types": ["T043"], "canonical_name": "activation of lymphocyte differentiation"}
{"concept_id": "C2249283", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of lymphocyte differentiation"}
{"concept_id": "C2249286", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T-helper cell differentiation"}
{"concept_id": "C2249287", "aliases": [], "types": ["T043"], "canonical_name": "activation of T-helper cell differentiation"}
{"concept_id": "C2249288", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T-helper cell differentiation"}
{"concept_id": "C2249291", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T-helper 1 cell differentiation"}
{"concept_id": "C2249292", "aliases": [], "types": ["T043"], "canonical_name": "activation of T-helper 1 cell differentiation"}
{"concept_id": "C2249293", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T-helper 1 cell differentiation"}
{"concept_id": "C2249296", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T-helper 2 cell differentiation"}
{"concept_id": "C2249297", "aliases": [], "types": ["T043"], "canonical_name": "activation of T-helper 2 cell differentiation"}
{"concept_id": "C2249298", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T-helper 2 cell differentiation"}
{"concept_id": "C2249301", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mechanoreceptor differentiation"}
{"concept_id": "C2249302", "aliases": [], "types": ["T043"], "canonical_name": "activation of mechanoreceptor differentiation"}
{"concept_id": "C2249303", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mechanoreceptor differentiation"}
{"concept_id": "C2249306", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of melanocyte differentiation"}
{"concept_id": "C2249307", "aliases": [], "types": ["T043"], "canonical_name": "activation of melanocyte differentiation"}
{"concept_id": "C2249308", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of melanocyte differentiation"}
{"concept_id": "C2249311", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myeloid cell differentiation"}
{"concept_id": "C2249312", "aliases": [], "types": ["T043"], "canonical_name": "activation of myeloid cell differentiation"}
{"concept_id": "C2249313", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of myeloid cell differentiation"}
{"concept_id": "C2249316", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of basophil differentiation"}
{"concept_id": "C2249317", "aliases": [], "types": ["T043"], "canonical_name": "activation of basophil differentiation"}
{"concept_id": "C2249318", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of basophil differentiation"}
{"concept_id": "C2249321", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of eosinophil differentiation"}
{"concept_id": "C2249322", "aliases": [], "types": ["T043"], "canonical_name": "activation of eosinophil differentiation"}
{"concept_id": "C2249323", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of eosinophil differentiation"}
{"concept_id": "C2249326", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of erythrocyte differentiation"}
{"concept_id": "C2249327", "aliases": ["stimulation of erythrocyte differentiation"], "types": ["T043"], "canonical_name": "activation of erythrocyte differentiation"}
{"concept_id": "C2249331", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of macrophage differentiation"}
{"concept_id": "C2249332", "aliases": [], "types": ["T043"], "canonical_name": "activation of macrophage differentiation"}
{"concept_id": "C2249333", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of macrophage differentiation"}
{"concept_id": "C2249336", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of megakaryocyte differentiation"}
{"concept_id": "C2249337", "aliases": [], "types": ["T043"], "canonical_name": "activation of megakaryocyte differentiation"}
{"concept_id": "C2249338", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of megakaryocyte differentiation"}
{"concept_id": "C2249341", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of monocyte differentiation"}
{"concept_id": "C2249342", "aliases": [], "types": ["T043"], "canonical_name": "activation of monocyte differentiation"}
{"concept_id": "C2249343", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of monocyte differentiation"}
{"concept_id": "C2249346", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil differentiation"}
{"concept_id": "C2249347", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil differentiation"}
{"concept_id": "C2249348", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neutrophil differentiation"}
{"concept_id": "C2249351", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myoblast differentiation"}
{"concept_id": "C2249352", "aliases": [], "types": ["T043"], "canonical_name": "activation of myoblast differentiation"}
{"concept_id": "C2249353", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of myoblast differentiation"}
{"concept_id": "C2249356", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuron differentiation"}
{"concept_id": "C2249357", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuron differentiation"}
{"concept_id": "C2249358", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neuron differentiation"}
{"concept_id": "C2249361", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of osteoblast differentiation"}
{"concept_id": "C2249362", "aliases": [], "types": ["T043"], "canonical_name": "activation of osteoblast differentiation"}
{"concept_id": "C2249363", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of osteoblast differentiation"}
{"concept_id": "C2249366", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of osteoclast differentiation"}
{"concept_id": "C2249367", "aliases": [], "types": ["T043"], "canonical_name": "activation of osteoclast differentiation"}
{"concept_id": "C2249368", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of osteoclast differentiation"}
{"concept_id": "C2249370", "aliases": [], "types": ["T043"], "canonical_name": "regulation of R7 cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of R7 differentiation. [GOC:go_curators]"}
{"concept_id": "C2249371", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of R7 differentiation"}
{"concept_id": "C2249372", "aliases": [], "types": ["T043"], "canonical_name": "activation of R7 differentiation"}
{"concept_id": "C2249373", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of R7 differentiation"}
{"concept_id": "C2249374", "aliases": [], "types": ["T043"], "canonical_name": "regulation of R8 cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of R8 differentiation. [GOC:go_curators]"}
{"concept_id": "C2249375", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of R8 differentiation"}
{"concept_id": "C2249376", "aliases": [], "types": ["T043"], "canonical_name": "activation of R8 differentiation"}
{"concept_id": "C2249377", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of R8 differentiation"}
{"concept_id": "C2249379", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of epidermis development"}
{"concept_id": "C2249380", "aliases": [], "types": ["T042"], "canonical_name": "activation of epidermis development"}
{"concept_id": "C2249381", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of epidermis development"}
{"concept_id": "C2249384", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glial cell differentiation"}
{"concept_id": "C2249385", "aliases": [], "types": ["T043"], "canonical_name": "activation of glial cell differentiation"}
{"concept_id": "C2249386", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of glial cell differentiation"}
{"concept_id": "C2249389", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of antipodal cell differentiation"}
{"concept_id": "C2249390", "aliases": [], "types": ["T043"], "canonical_name": "activation of antipodal cell differentiation"}
{"concept_id": "C2249391", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of antipodal cell differentiation"}
{"concept_id": "C2249393", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of female gametophyte central cell differentiation"}
{"concept_id": "C2249394", "aliases": [], "types": ["T043"], "canonical_name": "activation of female gametophyte central cell differentiation"}
{"concept_id": "C2249395", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of female gametophyte central cell differentiation"}
{"concept_id": "C2249396", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of female gametophyte egg cell differentiation"}
{"concept_id": "C2249397", "aliases": [], "types": ["T043"], "canonical_name": "activation of female gametophyte egg cell differentiation"}
{"concept_id": "C2249398", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of female gametophyte egg cell differentiation"}
{"concept_id": "C2249400", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synergid differentiation"}
{"concept_id": "C2249401", "aliases": [], "types": ["T043"], "canonical_name": "activation of synergid differentiation"}
{"concept_id": "C2249402", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of synergid differentiation"}
{"concept_id": "C2249405", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of spermatid nuclear differentiation"}
{"concept_id": "C2249406", "aliases": [], "types": ["T043"], "canonical_name": "activation of spermatid nuclear differentiation"}
{"concept_id": "C2249407", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of spermatid nuclear differentiation"}
{"concept_id": "C2249409", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of salivary gland determination"}
{"concept_id": "C2249410", "aliases": [], "types": ["T039"], "canonical_name": "activation of salivary gland determination"}
{"concept_id": "C2249411", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of salivary gland determination"}
{"concept_id": "C2249412", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of adult salivary gland determination"}
{"concept_id": "C2249413", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of larval salivary gland determination"}
{"concept_id": "C2249414", "aliases": [], "types": ["T039"], "canonical_name": "activation of adult salivary gland determination"}
{"concept_id": "C2249415", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of adult salivary gland determination"}
{"concept_id": "C2249416", "aliases": [], "types": ["T039"], "canonical_name": "activation of larval salivary gland determination"}
{"concept_id": "C2249417", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of larval salivary gland determination"}
{"concept_id": "C2249424", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fatty acid biosynthetic process"}
{"concept_id": "C2249428", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glycogen biosynthetic process"}
{"concept_id": "C2249430", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of integrin biosynthetic process"}
{"concept_id": "C2249432", "aliases": [], "types": ["T043"], "canonical_name": "activation of gluconeogenesis"}
{"concept_id": "C2249433", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of gluconeogenesis"}
{"concept_id": "C2249435", "aliases": [], "types": ["T043"], "canonical_name": "activation of fatty acid biosynthetic process"}
{"concept_id": "C2249436", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of fatty acid biosynthetic process"}
{"concept_id": "C2249441", "aliases": [], "types": ["T043"], "canonical_name": "activation of glycogen biosynthetic process"}
{"concept_id": "C2249442", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of glycogen biosynthetic process"}
{"concept_id": "C2249444", "aliases": [], "types": ["T043"], "canonical_name": "activation of integrin biosynthetic process"}
{"concept_id": "C2249445", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of integrin biosynthetic process"}
{"concept_id": "C2249447", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein biosynthetic process"}
{"concept_id": "C2249448", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein biosynthetic process"}
{"concept_id": "C2249449", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein catabolic process"}
{"concept_id": "C2249450", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein catabolic process"}
{"concept_id": "C2249453", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cyclin-dependent protein kinase activity"}
{"concept_id": "C2249454", "aliases": ["activation of cyclin-dependent protein kinase activity"], "types": ["T043"], "canonical_name": "activation of cyclin-dependent protein kinase activity"}
{"concept_id": "C2249455", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cyclin-dependent protein kinase activity"}
{"concept_id": "C2249458", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA repair"}
{"concept_id": "C2249459", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of DNA repair"}
{"concept_id": "C2249461", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA replication"}
{"concept_id": "C2249462", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of DNA replication"}
{"concept_id": "C2249464", "aliases": [], "types": ["T040"], "canonical_name": "activation of epidermal growth factor receptor activity"}
{"concept_id": "C2249465", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of epidermal growth factor receptor activity"}
{"concept_id": "C2249466", "aliases": ["up regulation of epidermal growth factor receptor activity", "upregulation of epidermal growth factor receptor activity", "up-regulation of epidermal growth factor receptor activity", "positive regulation of epidermal growth factor receptor activity", "positive regulation of EGFR activity", "positive regulation of EGF receptor activity"], "types": ["T044"], "canonical_name": "positive regulation of epidermal growth factor-activated receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. [GOC:go_curators]"}
{"concept_id": "C2249467", "aliases": [], "types": ["T040"], "canonical_name": "activation of epidermal growth factor receptor signaling pathway"}
{"concept_id": "C2249468", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of epidermal growth factor receptor signaling pathway"}
{"concept_id": "C2249470", "aliases": [], "types": ["T040"], "canonical_name": "activation of fibroblast growth factor receptor signaling pathway"}
{"concept_id": "C2249471", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of fibroblast growth factor receptor signaling pathway"}
{"concept_id": "C2249474", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of G-protein coupled receptor protein signaling pathway"}
{"concept_id": "C2249475", "aliases": [], "types": ["T043"], "canonical_name": "activation of G-protein coupled receptor protein signaling pathway"}
{"concept_id": "C2249476", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of G-protein coupled receptor protein signaling pathway"}
{"concept_id": "C2249479", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of Notch signaling pathway"}
{"concept_id": "C2249480", "aliases": [], "types": ["T040"], "canonical_name": "activation of Notch signaling pathway"}
{"concept_id": "C2249481", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of Notch signaling pathway"}
{"concept_id": "C2249483", "aliases": [], "types": ["T040"], "canonical_name": "activation of R8 spacing"}
{"concept_id": "C2249484", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of R8 spacing"}
{"concept_id": "C2249491", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of Toll signaling pathway"}
{"concept_id": "C2249492", "aliases": [], "types": ["T043"], "canonical_name": "activation of Toll signaling pathway"}
{"concept_id": "C2249493", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of Toll signaling pathway"}
{"concept_id": "C2249496", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of acetate catabolic process"}
{"concept_id": "C2249497", "aliases": [], "types": ["T043"], "canonical_name": "activation of acetate catabolic process"}
{"concept_id": "C2249498", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of acetate catabolic process"}
{"concept_id": "C2249501", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of initiation of acetate catabolic process by acetate"}
{"concept_id": "C2249502", "aliases": [], "types": ["T043"], "canonical_name": "activation of initiation of acetate catabolic process by acetate"}
{"concept_id": "C2249503", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of initiation of acetate catabolic process by acetate"}
{"concept_id": "C2249506", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of action potential"}
{"concept_id": "C2249507", "aliases": [], "types": ["T043"], "canonical_name": "activation of action potential"}
{"concept_id": "C2249508", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of action potential"}
{"concept_id": "C2249510", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of adenylate cyclase activity"}
{"concept_id": "C2249512", "aliases": ["down-regulation of amino acid metabolic process", "negative regulation of amino acid metabolism", "down regulation of amino acid metabolic process", "downregulation of amino acid metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of cellular amino acid metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid. [GOC:go_curators]"}
{"concept_id": "C2249513", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of amino acid metabolic process"}
{"concept_id": "C2249514", "aliases": [], "types": ["T043"], "canonical_name": "activation of amino acid metabolic process"}
{"concept_id": "C2249515", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of amino acid metabolic process"}
{"concept_id": "C2249516", "aliases": ["positive regulation of amino acid metabolism", "up regulation of amino acid metabolic process", "upregulation of amino acid metabolic process", "up-regulation of amino acid metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of cellular amino acid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. [GOC:go_curators]"}
{"concept_id": "C2249517", "aliases": [], "types": ["T040"], "canonical_name": "activation of angiogenesis"}
{"concept_id": "C2249518", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of angiogenesis"}
{"concept_id": "C2249524", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of asymmetric cell division"}
{"concept_id": "C2249525", "aliases": [], "types": ["T043"], "canonical_name": "activation of asymmetric cell division"}
{"concept_id": "C2249526", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of asymmetric cell division"}
{"concept_id": "C2249529", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of autophagic vacuole size"}
{"concept_id": "C2249530", "aliases": [], "types": ["T043"], "canonical_name": "activation of autophagic vacuole size"}
{"concept_id": "C2249531", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of autophagic vacuole size"}
{"concept_id": "C2249533", "aliases": [], "types": ["T043"], "canonical_name": "activation of axon extension"}
{"concept_id": "C2249534", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of axon extension"}
{"concept_id": "C2249537", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of beta 2 integrin biosynthetic process"}
{"concept_id": "C2249538", "aliases": [], "types": ["T043"], "canonical_name": "activation of beta 2 integrin biosynthetic process"}
{"concept_id": "C2249539", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of beta 2 integrin biosynthetic process"}
{"concept_id": "C2249542", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of blood pressure"}
{"concept_id": "C2249543", "aliases": [], "types": ["T040"], "canonical_name": "activation of blood pressure"}
{"concept_id": "C2249544", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of blood pressure"}
{"concept_id": "C2249546", "aliases": [], "types": ["T042"], "canonical_name": "activation of ossification"}
{"concept_id": "C2249547", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of ossification"}
{"concept_id": "C2249550", "aliases": ["adaptive immune response in jawless fish", "adaptive immune response based on somatic recombination of VLR built from LRR domains", "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains"], "types": ["T040"], "canonical_name": "adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains", "definition": "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae). [GOC:add, GOC:mtg_sensu, PMID:16373579]"}
{"concept_id": "C2249551", "aliases": [], "types": ["T040"], "canonical_name": "activation of bone resorption"}
{"concept_id": "C2249554", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell budding"}
{"concept_id": "C2249555", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell budding"}
{"concept_id": "C2249556", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell budding"}
{"concept_id": "C2249558", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell adhesion"}
{"concept_id": "C2249559", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell adhesion"}
{"concept_id": "C2249561", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of progression through cell cycle"}
{"concept_id": "C2249562", "aliases": [], "types": ["T043"], "canonical_name": "activation of progression through cell cycle"}
{"concept_id": "C2249563", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of progression through cell cycle"}
{"concept_id": "C2249565", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell size"}
{"concept_id": "C2249566", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell size"}
{"concept_id": "C2249567", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell size"}
{"concept_id": "C2249570", "aliases": ["downregulation of cholesterol absorption", "inhibition of cholesterol absorption", "down-regulation of cholesterol absorption", "down regulation of cholesterol absorption"], "types": ["T040"], "canonical_name": "negative regulation of intestinal cholesterol absorption", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine. [GOC:go_curators]"}
{"concept_id": "C2249571", "aliases": ["activation of cholesterol absorption", "stimulation of cholesterol absorption", "up regulation of cholesterol absorption", "up-regulation of cholesterol absorption", "upregulation of cholesterol absorption"], "types": ["T040"], "canonical_name": "positive regulation of intestinal cholesterol absorption", "definition": "Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine. [GOC:go_curators]"}
{"concept_id": "C2249579", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cuticle tanning"}
{"concept_id": "C2249580", "aliases": [], "types": ["T039"], "canonical_name": "activation of cuticle tanning"}
{"concept_id": "C2249581", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of cuticle tanning"}
{"concept_id": "C2249583", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of eclosion"}
{"concept_id": "C2249584", "aliases": [], "types": ["T040"], "canonical_name": "activation of eclosion"}
{"concept_id": "C2249585", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of eclosion"}
{"concept_id": "C2249588", "aliases": [], "types": ["T043"], "canonical_name": "activation of endocytosis"}
{"concept_id": "C2249589", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of endocytosis"}
{"concept_id": "C2249592", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of establishment of competence for transformation"}
{"concept_id": "C2249593", "aliases": [], "types": ["T040"], "canonical_name": "activation of establishment of competence for transformation"}
{"concept_id": "C2249594", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of establishment of competence for transformation"}
{"concept_id": "C2249596", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of frizzled-2 signaling pathway"}
{"concept_id": "C2249597", "aliases": [], "types": ["T043"], "canonical_name": "activation of frizzled-2 signaling pathway"}
{"concept_id": "C2249598", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of frizzled-2 signaling pathway"}
{"concept_id": "C2249600", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of gene expression, epigenetic"}
{"concept_id": "C2249601", "aliases": [], "types": ["T045"], "canonical_name": "activation of gene expression, epigenetic"}
{"concept_id": "C2249602", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of gene expression, epigenetic"}
{"concept_id": "C2249604", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of global transcription from RNA polymerase II promoter"}
{"concept_id": "C2249608", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glycogen catabolic process"}
{"concept_id": "C2249609", "aliases": [], "types": ["T043"], "canonical_name": "activation of glycogen catabolic process"}
{"concept_id": "C2249610", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of glycogen catabolic process"}
{"concept_id": "C2249613", "aliases": [], "types": ["T043"], "canonical_name": "activation of glycolysis"}
{"concept_id": "C2249614", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of glycolysis"}
{"concept_id": "C2249617", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of heart contraction"}
{"concept_id": "C2249618", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of cardiac contraction"}
{"concept_id": "C2249619", "aliases": [], "types": ["T039"], "canonical_name": "activation of heart contraction"}
{"concept_id": "C2249621", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of heart contraction"}
{"concept_id": "C2249624", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of innate immune response"}
{"concept_id": "C2249626", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of isoprenoid metabolic process"}
{"concept_id": "C2249627", "aliases": [], "types": ["T043"], "canonical_name": "activation of isoprenoid metabolic process"}
{"concept_id": "C2249628", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of isoprenoid metabolic process"}
{"concept_id": "C2249631", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of isotype switching"}
{"concept_id": "C2249634", "aliases": [], "types": ["T043"], "canonical_name": "activation of isotype switching"}
{"concept_id": "C2249637", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of isotype switching"}
{"concept_id": "C2249640", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of light-activated channel activity"}
{"concept_id": "C2249641", "aliases": [], "types": ["T043"], "canonical_name": "activation of light-activated channel activity"}
{"concept_id": "C2249642", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of light-activated channel activity"}
{"concept_id": "C2249645", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lipid metabolic process"}
{"concept_id": "C2249646", "aliases": [], "types": ["T043"], "canonical_name": "activation of lipid metabolic process"}
{"concept_id": "C2249647", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of lipid metabolic process"}
{"concept_id": "C2249650", "aliases": ["activation of meiosis"], "types": ["T043"], "canonical_name": "activation of meiosis", "definition": "Any process that starts the inactive process of meiosis. [GOC:dph, GOC:tb]"}
{"concept_id": "C2249651", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of meiosis"}
{"concept_id": "C2249654", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane potential"}
{"concept_id": "C2249655", "aliases": [], "types": ["T043"], "canonical_name": "activation of membrane potential"}
{"concept_id": "C2249656", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of membrane potential"}
{"concept_id": "C2249659", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitosis"}
{"concept_id": "C2249660", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mitosis"}
{"concept_id": "C2249663", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic metaphase/anaphase transition"}
{"concept_id": "C2249664", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic metaphase/anaphase transition"}
{"concept_id": "C2249665", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mitotic metaphase/anaphase transition"}
{"concept_id": "C2249668", "aliases": ["inhibition of striated muscle development", "down-regulation of striated muscle development", "downregulation of striated muscle development", "down regulation of striated muscle development"], "types": ["T042"], "canonical_name": "negative regulation of striated muscle tissue development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. [GOC:go_curators]"}
{"concept_id": "C2249669", "aliases": ["up regulation of striated muscle development", "upregulation of striated muscle development", "up-regulation of striated muscle development", "stimulation of striated muscle development", "activation of striated muscle development"], "types": ["T042"], "canonical_name": "positive regulation of striated muscle tissue development", "definition": "Any process that activates or increases the frequency, rate or extent of striated muscle development. [GOC:go_curators]"}
{"concept_id": "C2249673", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nitrogen utilization"}
{"concept_id": "C2249674", "aliases": [], "types": ["T043"], "canonical_name": "activation of nitrogen utilization"}
{"concept_id": "C2249675", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of nitrogen utilization"}
{"concept_id": "C2249677", "aliases": ["negative regulation of nurse cell apoptosis", "down regulation of nurse cell apoptosis", "downregulation of nurse cell apoptosis", "down-regulation of nurse cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of nurse cell apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process. [GOC:go_curators, GOC:mtg_apoptosis]"}
{"concept_id": "C2249678", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nurse cell apoptosis"}
{"concept_id": "C2249679", "aliases": [], "types": ["T043"], "canonical_name": "activation of nurse cell apoptosis"}
{"concept_id": "C2249680", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of nurse cell apoptosis"}
{"concept_id": "C2249683", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of bicoid mRNA localization"}
{"concept_id": "C2249684", "aliases": [], "types": ["T045"], "canonical_name": "activation of bicoid mRNA localization"}
{"concept_id": "C2249685", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of bicoid mRNA localization"}
{"concept_id": "C2249688", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of pole plasm oskar mRNA localization"}
{"concept_id": "C2249689", "aliases": [], "types": ["T045"], "canonical_name": "activation of pole plasm oskar mRNA localization"}
{"concept_id": "C2249690", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of pole plasm oskar mRNA localization"}
{"concept_id": "C2249695", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein kinase activity"}
{"concept_id": "C2249698", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of proteolysis"}
{"concept_id": "C2249699", "aliases": [], "types": ["T044"], "canonical_name": "activation of proteolysis"}
{"concept_id": "C2249700", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of proteolysis"}
{"concept_id": "C2249703", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pteridine metabolic process"}
{"concept_id": "C2249704", "aliases": [], "types": ["T043"], "canonical_name": "activation of pteridine metabolic process"}
{"concept_id": "C2249705", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of pteridine metabolic process"}
{"concept_id": "C2249708", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of retroviral genome replication"}
{"concept_id": "C2249709", "aliases": [], "types": ["T045"], "canonical_name": "activation of retroviral genome replication"}
{"concept_id": "C2249710", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of retroviral genome replication"}
{"concept_id": "C2249716", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sevenless signaling pathway"}
{"concept_id": "C2249717", "aliases": [], "types": ["T044"], "canonical_name": "activation of sevenless signaling pathway"}
{"concept_id": "C2249718", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of sevenless signaling pathway"}
{"concept_id": "C2249721", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sister chromatid cohesion"}
{"concept_id": "C2249722", "aliases": [], "types": ["T043"], "canonical_name": "activation of sister chromatid cohesion"}
{"concept_id": "C2249723", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of sister chromatid cohesion"}
{"concept_id": "C2249726", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of smoothened signaling pathway"}
{"concept_id": "C2249727", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of smoothened receptor activity by patched"}
{"concept_id": "C2249728", "aliases": [], "types": ["T040"], "canonical_name": "activation of smoothened signaling pathway"}
{"concept_id": "C2249729", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of smoothened receptor activity by patched"}
{"concept_id": "C2249730", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of smoothened signaling pathway"}
{"concept_id": "C2249732", "aliases": [], "types": ["T043"], "canonical_name": "activation of sporulation"}
{"concept_id": "C2249733", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of sporulation"}
{"concept_id": "C2249734", "aliases": ["upregulation of sporulation", "up regulation of sporulation", "up-regulation of sporulation"], "types": ["T043"], "canonical_name": "positive regulation of sporulation resulting in formation of a cellular spore", "definition": "Any process that activates or increases the frequency, rate or extent of sporulation. [GOC:go_curators]"}
{"concept_id": "C2249736", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sulfur utilization"}
{"concept_id": "C2249737", "aliases": [], "types": ["T043"], "canonical_name": "activation of sulfur utilization"}
{"concept_id": "C2249738", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of sulfur utilization"}
{"concept_id": "C2249743", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of synaptic growth at neuromuscular junction"}
{"concept_id": "C2249744", "aliases": [], "types": ["T040"], "canonical_name": "activation of synaptic growth at neuromuscular junction"}
{"concept_id": "C2249745", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of synaptic growth at neuromuscular junction"}
{"concept_id": "C2249752", "aliases": ["down regulation of transcription, mating-type specific", "downregulation of transcription, mating-type specific", "down-regulation of transcription, mating-type specific", "negative regulation of mating-type specific transcription, DNA-dependent"], "types": ["T045"], "canonical_name": "negative regulation of mating-type specific transcription, DNA-templated", "definition": "Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C2249753", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription, mating-type specific"}
{"concept_id": "C2249754", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription, mating-type specific"}
{"concept_id": "C2249755", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription, mating-type specific"}
{"concept_id": "C2249756", "aliases": ["positive regulation of mating-type specific transcription, DNA-dependent", "up regulation of transcription, mating-type specific", "up-regulation of transcription, mating-type specific", "upregulation of transcription, mating-type specific"], "types": ["T045"], "canonical_name": "positive regulation of mating-type specific transcription, DNA-templated", "definition": "Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]"}
{"concept_id": "C2249762", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of translational elongation"}
{"concept_id": "C2249763", "aliases": [], "types": ["T045"], "canonical_name": "activation of translational elongation"}
{"concept_id": "C2249764", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of translational elongation"}
{"concept_id": "C2249767", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of translational fidelity"}
{"concept_id": "C2249768", "aliases": [], "types": ["T043"], "canonical_name": "activation of translational fidelity"}
{"concept_id": "C2249769", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of translational fidelity"}
{"concept_id": "C2249772", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of translational termination"}
{"concept_id": "C2249773", "aliases": [], "types": ["T045"], "canonical_name": "activation of translational termination"}
{"concept_id": "C2249774", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of translational termination"}
{"concept_id": "C2249777", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of vasoconstriction"}
{"concept_id": "C2249778", "aliases": [], "types": ["T040"], "canonical_name": "activation of vasoconstriction"}
{"concept_id": "C2249779", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of vasoconstriction"}
{"concept_id": "C2249787", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA recombination"}
{"concept_id": "C2249788", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA recombination"}
{"concept_id": "C2249789", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of DNA recombination"}
{"concept_id": "C2249792", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of carbohydrate metabolic process"}
{"concept_id": "C2249793", "aliases": [], "types": ["T043"], "canonical_name": "activation of carbohydrate metabolic process"}
{"concept_id": "C2249794", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of carbohydrate metabolic process"}
{"concept_id": "C2249797", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of catecholamine metabolic process"}
{"concept_id": "C2249798", "aliases": [], "types": ["T043"], "canonical_name": "activation of catecholamine metabolic process"}
{"concept_id": "C2249799", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of catecholamine metabolic process"}
{"concept_id": "C2249802", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of complement activation"}
{"concept_id": "C2249803", "aliases": [], "types": ["T043"], "canonical_name": "activation of complement activation"}
{"concept_id": "C2249804", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of complement activation"}
{"concept_id": "C2249807", "aliases": [], "types": ["T043"], "canonical_name": "activation of cytolysis"}
{"concept_id": "C2249808", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cytolysis"}
{"concept_id": "C2249811", "aliases": [], "types": ["T043"], "canonical_name": "activation of exocytosis"}
{"concept_id": "C2249812", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of exocytosis"}
{"concept_id": "C2249815", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fatty acid metabolic process"}
{"concept_id": "C2249816", "aliases": [], "types": ["T043"], "canonical_name": "activation of fatty acid metabolic process"}
{"concept_id": "C2249817", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of fatty acid metabolic process"}
{"concept_id": "C2249819", "aliases": [], "types": ["T040"], "canonical_name": "activation of female receptivity"}
{"concept_id": "C2249820", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of female receptivity"}
{"concept_id": "C2249823", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of growth"}
{"concept_id": "C2249824", "aliases": [], "types": ["T040"], "canonical_name": "activation of growth"}
{"concept_id": "C2249825", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of growth"}
{"concept_id": "C2249828", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of juvenile hormone metabolic process"}
{"concept_id": "C2249829", "aliases": [], "types": ["T043"], "canonical_name": "activation of juvenile hormone metabolic process"}
{"concept_id": "C2249830", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of juvenile hormone metabolic process"}
{"concept_id": "C2249832", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of progression through mitotic cell cycle"}
{"concept_id": "C2249833", "aliases": [], "types": ["T043"], "canonical_name": "activation of progression through mitotic cell cycle"}
{"concept_id": "C2249834", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of progression through mitotic cell cycle"}
{"concept_id": "C2249836", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of muscle contraction"}
{"concept_id": "C2249837", "aliases": [], "types": ["T040"], "canonical_name": "activation of muscle contraction"}
{"concept_id": "C2249838", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of muscle contraction"}
{"concept_id": "C2249841", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}
{"concept_id": "C2249842", "aliases": [], "types": ["T043"], "canonical_name": "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}
{"concept_id": "C2249843", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}
{"concept_id": "C2249846", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of phosphate metabolic process"}
{"concept_id": "C2249847", "aliases": [], "types": ["T043"], "canonical_name": "activation of phosphate metabolic process"}
{"concept_id": "C2249848", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of phosphate metabolic process"}
{"concept_id": "C2249850", "aliases": [], "types": ["T040"], "canonical_name": "activation of circadian sleep/wake cycle, sleep"}
{"concept_id": "C2249851", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of circadian sleep/wake cycle, sleep"}
{"concept_id": "C2249854", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of steroid metabolic process"}
{"concept_id": "C2249855", "aliases": [], "types": ["T043"], "canonical_name": "activation of steroid metabolic process"}
{"concept_id": "C2249856", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of steroid metabolic process"}
{"concept_id": "C2249861", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of phosphorus utilization"}
{"concept_id": "C2249862", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription from RNA polymerase I promoter"}
{"concept_id": "C2249863", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription from RNA polymerase I promoter"}
{"concept_id": "C2249868", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription from RNA polymerase III promoter"}
{"concept_id": "C2249869", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription from RNA polymerase III promoter"}
{"concept_id": "C2249872", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of translational initiation"}
{"concept_id": "C2249873", "aliases": [], "types": ["T043"], "canonical_name": "activation of translational initiation"}
{"concept_id": "C2249874", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of translational initiation"}
{"concept_id": "C2249876", "aliases": [], "types": ["T043"], "canonical_name": "activation of phosphorus utilization"}
{"concept_id": "C2249877", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of phosphorus utilization"}
{"concept_id": "C2249880", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic recombination"}
{"concept_id": "C2249881", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic recombination"}
{"concept_id": "C2249882", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mitotic recombination"}
{"concept_id": "C2249885", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell mediated cytotoxicity"}
{"concept_id": "C2249886", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell mediated cytotoxicity"}
{"concept_id": "C2249887", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell mediated cytotoxicity"}
{"concept_id": "C2249890", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcium ion-dependent exocytosis"}
{"concept_id": "C2249891", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium ion-dependent exocytosis"}
{"concept_id": "C2249892", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of calcium ion-dependent exocytosis"}
{"concept_id": "C2249895", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of complement activation, alternative pathway"}
{"concept_id": "C2249896", "aliases": [], "types": ["T043"], "canonical_name": "activation of complement activation, alternative pathway"}
{"concept_id": "C2249897", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of complement activation, alternative pathway"}
{"concept_id": "C2249900", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of complement activation, classical pathway"}
{"concept_id": "C2249901", "aliases": [], "types": ["T043"], "canonical_name": "activation of complement activation, classical pathway"}
{"concept_id": "C2249902", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of complement activation, classical pathway"}
{"concept_id": "C2249905", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of development, heterochronic"}
{"concept_id": "C2249906", "aliases": [], "types": ["T040"], "canonical_name": "activation of development, heterochronic"}
{"concept_id": "C2249907", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of development, heterochronic"}
{"concept_id": "C2249910", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dopamine metabolic process"}
{"concept_id": "C2249911", "aliases": [], "types": ["T043"], "canonical_name": "activation of dopamine metabolic process"}
{"concept_id": "C2249912", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of dopamine metabolic process"}
{"concept_id": "C2249915", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of ecdysteroid metabolic process"}
{"concept_id": "C2249916", "aliases": [], "types": ["T043"], "canonical_name": "activation of ecdysteroid metabolic process"}
{"concept_id": "C2249917", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of ecdysteroid metabolic process"}
{"concept_id": "C2249920", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of growth rate"}
{"concept_id": "C2249922", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of juvenile hormone biosynthetic process"}
{"concept_id": "C2249923", "aliases": [], "types": ["T043"], "canonical_name": "activation of juvenile hormone biosynthetic process"}
{"concept_id": "C2249924", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of juvenile hormone biosynthetic process"}
{"concept_id": "C2249927", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of juvenile hormone catabolic process"}
{"concept_id": "C2249928", "aliases": [], "types": ["T043"], "canonical_name": "activation of juvenile hormone catabolic process"}
{"concept_id": "C2249929", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of juvenile hormone catabolic process"}
{"concept_id": "C2249932", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of juvenile hormone secretion"}
{"concept_id": "C2249933", "aliases": [], "types": ["T043"], "canonical_name": "activation of juvenile hormone secretion"}
{"concept_id": "C2249934", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of juvenile hormone secretion"}
{"concept_id": "C2249936", "aliases": [], "types": ["T045"], "canonical_name": "regulation of translation, ncRNA-mediated", "definition": "Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C2249937", "aliases": ["up regulation of mRNA translation, ncRNA-mediated", "up-regulation of mRNA translation, ncRNA-mediated", "upregulation of mRNA translation, ncRNA-mediated"], "types": ["T045"], "canonical_name": "positive regulation of translation, ncRNA-mediated", "definition": "Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein. [GOC:dph, GOC:go_curators, GOC:tb]"}
{"concept_id": "C2249938", "aliases": [], "types": ["T045"], "canonical_name": "activation of mRNA translation, ncRNA-mediated"}
{"concept_id": "C2249939", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of mRNA translation, ncRNA-mediated"}
{"concept_id": "C2249940", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of progression through embryonic mitotic cell cycle"}
{"concept_id": "C2249941", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic cell cycle, embryonic"}
{"concept_id": "C2249943", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mitotic cell cycle, embryonic"}
{"concept_id": "C2249946", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nucleoside metabolic process"}
{"concept_id": "C2249947", "aliases": [], "types": ["T043"], "canonical_name": "activation of nucleoside metabolic process"}
{"concept_id": "C2249948", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of nucleoside metabolic process"}
{"concept_id": "C2249951", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nucleotide metabolic process"}
{"concept_id": "C2249952", "aliases": [], "types": ["T043"], "canonical_name": "activation of nucleotide metabolic process"}
{"concept_id": "C2249953", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of nucleotide metabolic process"}
{"concept_id": "C2249956", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of purine base metabolic process"}
{"concept_id": "C2249957", "aliases": [], "types": ["T043"], "canonical_name": "activation of purine base metabolic process"}
{"concept_id": "C2249958", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of purine base metabolic process"}
{"concept_id": "C2249961", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pyrimidine base metabolic process"}
{"concept_id": "C2249962", "aliases": [], "types": ["T043"], "canonical_name": "activation of pyrimidine base metabolic process"}
{"concept_id": "C2249963", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of pyrimidine base metabolic process"}
{"concept_id": "C2249966", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of smooth muscle contraction"}
{"concept_id": "C2249967", "aliases": ["smooth muscle relaxation"], "types": ["T042"], "canonical_name": "relaxation of smooth muscle", "definition": "A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. [GOC:jl]"}
{"concept_id": "C2249968", "aliases": [], "types": ["T040"], "canonical_name": "activation of smooth muscle contraction"}
{"concept_id": "C2249969", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of smooth muscle contraction"}
{"concept_id": "C2249972", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of striated muscle contraction"}
{"concept_id": "C2249973", "aliases": [], "types": ["T040"], "canonical_name": "activation of striated muscle contraction"}
{"concept_id": "C2249974", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of striated muscle contraction"}
{"concept_id": "C2249980", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of embryonic development"}
{"concept_id": "C2249982", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of translational initiation by iron"}
{"concept_id": "C2249983", "aliases": [], "types": ["T043"], "canonical_name": "activation of translational initiation by iron"}
{"concept_id": "C2249984", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of translational initiation by iron"}
{"concept_id": "C2249989", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ecdysteroid biosynthetic process"}
{"concept_id": "C2249990", "aliases": [], "types": ["T043"], "canonical_name": "activation of ecdysteroid biosynthetic process"}
{"concept_id": "C2249991", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of ecdysteroid biosynthetic process"}
{"concept_id": "C2249994", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ecdysteroid secretion"}
{"concept_id": "C2249995", "aliases": [], "types": ["T043"], "canonical_name": "activation of ecdysteroid secretion"}
{"concept_id": "C2249996", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of ecdysteroid secretion"}
{"concept_id": "C2249998", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of progression through preblastoderm mitotic cell cycle"}
{"concept_id": "C2249999", "aliases": [], "types": ["T043"], "canonical_name": "activation of progression through preblastoderm mitotic cell cycle"}
{"concept_id": "C2250000", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of progression through preblastoderm mitotic cell cycle"}
{"concept_id": "C2250001", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of progression through syncytial blastoderm mitotic cell cycle"}
{"concept_id": "C2250002", "aliases": [], "types": ["T043"], "canonical_name": "activation of progression through syncytial blastoderm mitotic cell cycle"}
{"concept_id": "C2250003", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of progression through syncytial blastoderm mitotic cell cycle"}
{"concept_id": "C2250004", "aliases": [], "types": ["T040"], "canonical_name": "activation of circadian sleep/wake cycle, REM sleep"}
{"concept_id": "C2250005", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of circadian sleep/wake cycle, REM sleep"}
{"concept_id": "C2250008", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of activated T cell proliferation"}
{"concept_id": "C2250009", "aliases": [], "types": ["T040"], "canonical_name": "activation of female receptivity, post-mating"}
{"concept_id": "C2250010", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of female receptivity, post-mating"}
{"concept_id": "C2250012", "aliases": [], "types": ["T040"], "canonical_name": "activation of circadian sleep/wake cycle, non-REM sleep"}
{"concept_id": "C2250013", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of circadian sleep/wake cycle, non-REM sleep"}
{"concept_id": "C2250015", "aliases": [], "types": ["T045"], "canonical_name": "activation of oskar mRNA translation"}
{"concept_id": "C2250016", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of oskar mRNA translation"}
{"concept_id": "C2250019", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell homeostatic proliferation"}
{"concept_id": "C2250020", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription by glucose"}
{"concept_id": "C2250021", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription by glucose"}
{"concept_id": "C2250034", "aliases": [], "types": ["T044"], "canonical_name": "precorrin-6Y methylase activity"}
{"concept_id": "C2250040", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent mannitol dehydrogenase activity"}
{"concept_id": "C2250041", "aliases": [], "types": ["T043"], "canonical_name": "activation of vitamin metabolic process"}
{"concept_id": "C2250042", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of vitamin metabolic process"}
{"concept_id": "C2250045", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vitamin metabolic process"}
{"concept_id": "C2250051", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glucosylceramide biosynthetic process"}
{"concept_id": "C2250052", "aliases": [], "types": ["T043"], "canonical_name": "activation of glucosylceramide biosynthetic process"}
{"concept_id": "C2250053", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of glucosylceramide biosynthetic process"}
{"concept_id": "C2250055", "aliases": [], "types": ["T043"], "canonical_name": "activation of fatty acid oxidation"}
{"concept_id": "C2250056", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of fatty acid oxidation"}
{"concept_id": "C2250059", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fatty acid oxidation"}
{"concept_id": "C2250061", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glucose import"}
{"concept_id": "C2250062", "aliases": [], "types": ["T043"], "canonical_name": "activation of glucose import"}
{"concept_id": "C2250063", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of glucose import"}
{"concept_id": "C2250066", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of JNK cascade"}
{"concept_id": "C2250067", "aliases": [], "types": ["T043"], "canonical_name": "activation of JNK cascade"}
{"concept_id": "C2250068", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of JNK cascade"}
{"concept_id": "C2250070", "aliases": [], "types": ["T044"], "canonical_name": "3'-aminoglycoside acetyltransferase activity"}
{"concept_id": "C2250071", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA:gentamicin-C N3'-acetyltransferase activity"}
{"concept_id": "C2250072", "aliases": [], "types": ["T044"], "canonical_name": "aminoglycoside acetyltransferase AAC(3)-1"}
{"concept_id": "C2250073", "aliases": [], "types": ["T044"], "canonical_name": "aminoglycoside acetyltransferase AAC(3)-I activity"}
{"concept_id": "C2250074", "aliases": [], "types": ["T044"], "canonical_name": "gentamicin acetyltransferase I activity"}
{"concept_id": "C2250075", "aliases": [], "types": ["T044"], "canonical_name": "gentamycin acetyltransferase I"}
{"concept_id": "C2250103", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of JAK-STAT cascade"}
{"concept_id": "C2250104", "aliases": [], "types": ["T043"], "canonical_name": "activation of JAK-STAT cascade"}
{"concept_id": "C2250105", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of JAK-STAT cascade"}
{"concept_id": "C2250113", "aliases": [], "types": ["T044"], "canonical_name": "interlipid galactosyltransferase activity"}
{"concept_id": "C2250114", "aliases": [], "types": ["T044"], "canonical_name": "plasmalogen metabolic process"}
{"concept_id": "C2250119", "aliases": [], "types": ["T044"], "canonical_name": "1beta-MGDG"}
{"concept_id": "C2250143", "aliases": [], "types": ["T044"], "canonical_name": "galactosyltransferase I activity"}
{"concept_id": "C2250151", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of photoreceptor cell differentiation"}
{"concept_id": "C2250153", "aliases": [], "types": ["T043"], "canonical_name": "activation of photoreceptor cell differentiation"}
{"concept_id": "C2250155", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of photoreceptor cell differentiation"}
{"concept_id": "C2250162", "aliases": [], "types": ["T044"], "canonical_name": "histamine-methylating enzyme"}
{"concept_id": "C2250168", "aliases": [], "types": ["T044"], "canonical_name": "bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)"}
{"concept_id": "C2250215", "aliases": [], "types": ["T044"], "canonical_name": "deoxin-1"}
{"concept_id": "C2250219", "aliases": [], "types": ["T044"], "canonical_name": "microcid"}
{"concept_id": "C2250224", "aliases": ["3-methylbutanal reductase [NAD(P)] activity", "3-methylbutyraldehyde reductase activity", "isoamyl alcohol oxidase activity"], "types": ["T044"], "canonical_name": "3-methylbutanol:NAD(P) oxidoreductase activity", "definition": "Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde. [EC:1.1.1.265]"}
{"concept_id": "C2250230", "aliases": [], "types": ["T043"], "canonical_name": "activation of Ras protein signal transduction"}
{"concept_id": "C2250231", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of Ras protein signal transduction"}
{"concept_id": "C2250234", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Ras protein signal transduction"}
{"concept_id": "C2250235", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium-dependent cell-cell adhesion"}
{"concept_id": "C2250236", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of calcium-dependent cell-cell adhesion"}
{"concept_id": "C2250239", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcium-dependent cell-cell adhesion"}
{"concept_id": "C2250240", "aliases": [], "types": ["T045"], "canonical_name": "Aspergillus oryzae ribonuclease activity"}
{"concept_id": "C2250243", "aliases": [], "types": ["T045"], "canonical_name": "ribonuclease C2"}
{"concept_id": "C2250244", "aliases": [], "types": ["T045"], "canonical_name": "ribonuclease Ch"}
{"concept_id": "C2250247", "aliases": [], "types": ["T045"], "canonical_name": "ribonuclease N3"}
{"concept_id": "C2250248", "aliases": [], "types": ["T045"], "canonical_name": "ribonuclease PP1"}
{"concept_id": "C2250249", "aliases": ["ribonuclease SA"], "types": ["T045"], "canonical_name": "RNase Sa"}
{"concept_id": "C2250250", "aliases": [], "types": ["T045"], "canonical_name": "ribonuclease U1"}
{"concept_id": "C2250251", "aliases": [], "types": ["T045"], "canonical_name": "RNase G"}
{"concept_id": "C2250261", "aliases": ["regulation of viral penetration into host cell"], "types": ["T043"], "canonical_name": "regulation of viral entry into host cell", "definition": "Any process that modulates the frequency, rate or extent of the viral entry into the host cell. [GOC:jl]"}
{"concept_id": "C2250262", "aliases": ["negative regulation of viral penetration into host cell"], "types": ["T043"], "canonical_name": "negative regulation of viral entry into host cell", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell. [GOC:jl]"}
{"concept_id": "C2250264", "aliases": ["positive regulation of viral penetration into host cell"], "types": ["T038"], "canonical_name": "positive regulation of viral entry into host cell", "definition": "Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell. [GOC:jl]"}
{"concept_id": "C2250268", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of centriole replication"}
{"concept_id": "C2250269", "aliases": [], "types": ["T045"], "canonical_name": "activation of centriole replication"}
{"concept_id": "C2250270", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of centriole replication"}
{"concept_id": "C2250273", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic centrosome separation"}
{"concept_id": "C2250274", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic centrosome separation"}
{"concept_id": "C2250275", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mitotic centrosome separation"}
{"concept_id": "C2250278", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of centrosome cycle"}
{"concept_id": "C2250279", "aliases": [], "types": ["T043"], "canonical_name": "activation of centrosome cycle"}
{"concept_id": "C2250280", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of centrosome cycle"}
{"concept_id": "C2250287", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of insulin receptor signaling pathway"}
{"concept_id": "C2250288", "aliases": [], "types": ["T040"], "canonical_name": "activation of insulin receptor signaling pathway"}
{"concept_id": "C2250289", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of insulin receptor signaling pathway"}
{"concept_id": "C2250291", "aliases": [], "types": ["T043"], "canonical_name": "activation of alpha-beta T cell activation"}
{"concept_id": "C2250292", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of alpha-beta T cell activation"}
{"concept_id": "C2250295", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of alpha-beta T cell activation"}
{"concept_id": "C2250296", "aliases": [], "types": ["T043"], "canonical_name": "activation of alpha-beta T cell differentiation"}
{"concept_id": "C2250297", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of alpha-beta T cell differentiation"}
{"concept_id": "C2250300", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of alpha-beta T cell differentiation"}
{"concept_id": "C2250301", "aliases": [], "types": ["T043"], "canonical_name": "activation of alpha-beta T cell proliferation"}
{"concept_id": "C2250302", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of alpha-beta T cell proliferation"}
{"concept_id": "C2250305", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of alpha-beta T cell proliferation"}
{"concept_id": "C2250307", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gamma-delta T cell activation"}
{"concept_id": "C2250308", "aliases": [], "types": ["T043"], "canonical_name": "activation of gamma-delta T cell activation"}
{"concept_id": "C2250309", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of gamma-delta T cell activation"}
{"concept_id": "C2250312", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gamma-delta T cell proliferation"}
{"concept_id": "C2250313", "aliases": [], "types": ["T043"], "canonical_name": "activation of gamma-delta T cell proliferation"}
{"concept_id": "C2250314", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of gamma-delta T cell proliferation"}
{"concept_id": "C2250316", "aliases": [], "types": ["T043"], "canonical_name": "activation of retinal programmed cell death"}
{"concept_id": "C2250317", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of retinal programmed cell death"}
{"concept_id": "C2250318", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of retinal programmed cell death"}
{"concept_id": "C2250323", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of insulin secretion"}
{"concept_id": "C2250325", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of viral protein levels in host cell"}
{"concept_id": "C2250326", "aliases": [], "types": ["T043"], "canonical_name": "activation of viral protein levels in host cell"}
{"concept_id": "C2250327", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of viral protein levels in host cell"}
{"concept_id": "C2250332", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nucleocytoplasmic transport"}
{"concept_id": "C2250333", "aliases": [], "types": ["T043"], "canonical_name": "activation of nucleocytoplasmic transport"}
{"concept_id": "C2250334", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of nucleocytoplasmic transport"}
{"concept_id": "C2250337", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein export from nucleus"}
{"concept_id": "C2250338", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein export from nucleus"}
{"concept_id": "C2250339", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein export from nucleus"}
{"concept_id": "C2250342", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of RNA import into nucleus"}
{"concept_id": "C2250343", "aliases": [], "types": ["T043"], "canonical_name": "activation of RNA import into nucleus"}
{"concept_id": "C2250344", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of RNA import into nucleus"}
{"concept_id": "C2250347", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of RNA export from nucleus"}
{"concept_id": "C2250348", "aliases": [], "types": ["T043"], "canonical_name": "activation of RNA export from nucleus"}
{"concept_id": "C2250349", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of RNA export from nucleus"}
{"concept_id": "C2250352", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of bone remodeling"}
{"concept_id": "C2250353", "aliases": [], "types": ["T040"], "canonical_name": "activation of bone remodeling"}
{"concept_id": "C2250354", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of bone remodeling"}
{"concept_id": "C2250356", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol and derivative phosphorylation"}
{"concept_id": "C2250357", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol phosphate dephosphorylation"}
{"concept_id": "C2250359", "aliases": [], "types": ["T044"], "canonical_name": "metal ion transmembrane transporter activity", "definition": "Enables the transfer of metal ions from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C2250360", "aliases": [], "types": ["T042"], "canonical_name": "activation of saliva secretion"}
{"concept_id": "C2250361", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of saliva secretion"}
{"concept_id": "C2250363", "aliases": [], "types": ["T043"], "canonical_name": "activation of follicle-stimulating hormone secretion"}
{"concept_id": "C2250364", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of follicle-stimulating hormone secretion"}
{"concept_id": "C2250367", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of follicle-stimulating hormone secretion"}
{"concept_id": "C2250369", "aliases": [], "types": ["T040"], "canonical_name": "activation of hormone biosynthetic process"}
{"concept_id": "C2250370", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of hormone biosynthetic process"}
{"concept_id": "C2250372", "aliases": [], "types": ["T043"], "canonical_name": "activation of hormone secretion"}
{"concept_id": "C2250373", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of hormone secretion"}
{"concept_id": "C2250376", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hormone secretion"}
{"concept_id": "C2250377", "aliases": [], "types": ["T040"], "canonical_name": "activation of lipid biosynthetic process"}
{"concept_id": "C2250378", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of lipid biosynthetic process"}
{"concept_id": "C2250380", "aliases": [], "types": ["T044"], "canonical_name": "guanosine triphosphate-adenylate kinase"}
{"concept_id": "C2250392", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neurotransmitter secretion"}
{"concept_id": "C2250394", "aliases": [], "types": ["T044"], "canonical_name": "type I phosphoinositide 3-kinase activity"}
{"concept_id": "C2250396", "aliases": [], "types": ["T044"], "canonical_name": "ATP synthase activity"}
{"concept_id": "C2250398", "aliases": [], "types": ["T044"], "canonical_name": "chloroplast ATPase activity"}
{"concept_id": "C2250400", "aliases": [], "types": ["T044"], "canonical_name": "F(0)F(1)-ATPase activity"}
{"concept_id": "C2250401", "aliases": ["F1-ATPase"], "types": ["T044"], "definition": "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria. [TC:3.A.2.1.1, TC:3.A.2.1.3]", "canonical_name": "F(1)-ATPase activity"}
{"concept_id": "C2250402", "aliases": [], "types": ["T044"], "canonical_name": "F(o)F(1)-ATPase activity"}
{"concept_id": "C2250403", "aliases": [], "types": ["T044"], "canonical_name": "F0F1-ATPase"}
{"concept_id": "C2250404", "aliases": [], "types": ["T044"], "canonical_name": "FoF1-ATPase"}
{"concept_id": "C2250407", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial ATPase activity"}
{"concept_id": "C2250413", "aliases": [], "types": ["T044"], "canonical_name": "Na+-translocating F1Fo-ATPase"}
{"concept_id": "C2250414", "aliases": [], "types": ["T044"], "canonical_name": "Na+-transporting two-sector ATPase"}
{"concept_id": "C2250415", "aliases": [], "types": ["T044"], "canonical_name": "vacuolar-type Na+-ATPase"}
{"concept_id": "C2250416", "aliases": [], "types": ["T044"], "canonical_name": "vacuolar-type Na+-translocating ATPase"}
{"concept_id": "C2250418", "aliases": [], "types": ["T040"], "canonical_name": "activation of hemoglobin biosynthetic process"}
{"concept_id": "C2250419", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of hemoglobin biosynthetic process"}
{"concept_id": "C2250422", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hemoglobin biosynthetic process"}
{"concept_id": "C2250448", "aliases": [], "types": ["T044"], "canonical_name": "20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity"}
{"concept_id": "C2250449", "aliases": [], "types": ["T044"], "canonical_name": "21-hydroxysteroid:NAD+ 21-oxidoreductase activity"}
{"concept_id": "C2250450", "aliases": ["21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity"], "types": ["T044"], "canonical_name": "21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity"}
{"concept_id": "C2250451", "aliases": [], "types": ["T044"], "canonical_name": "21-hydroxy steroid dehydrogenase activity"}
{"concept_id": "C2250452", "aliases": [], "types": ["T044"], "canonical_name": "21-hydroxysteroid:NADP+ 21-oxidoreductase activity"}
{"concept_id": "C2250461", "aliases": [], "types": ["T044"], "canonical_name": "3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity"}
{"concept_id": "C2250462", "aliases": [], "types": ["T044"], "canonical_name": "3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity"}
{"concept_id": "C2250463", "aliases": ["3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)"], "types": ["T044"], "canonical_name": "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)"}
{"concept_id": "C2250464", "aliases": [], "types": ["T044"], "canonical_name": "sterol 4-alpha-carboxylic decarboxylase activity"}
{"concept_id": "C2250465", "aliases": [], "types": ["T044"], "canonical_name": "12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity"}
{"concept_id": "C2250466", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C2250467", "aliases": [], "types": ["T044"], "canonical_name": "NADP-12alpha-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C2250469", "aliases": ["glycerin-3-phosphate dehydrogenase activity", "L-glycerol 3-phosphate:NADP oxidoreductase activity", "NADPH-dependent glycerin-3-phosphate dehydrogenase activity", "glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity", "sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "glycerol-3-phosphate 1-dehydrogenase [NADP+] activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP(+) = D-glyceraldehyde 3-phosphate + H(+) + NADPH. [EC:1.1.1.177, RHEA:19773]"}
{"concept_id": "C2250476", "aliases": ["3beta-hydroxy-delta5-C27-steroid oxidoreductase"], "types": ["T044"], "canonical_name": "3beta-hydroxy-delta5-C27-steroid oxidoreductase"}
{"concept_id": "C2250504", "aliases": ["NADP-dependent 15-hydroxyprostaglandin dehydrogenase"], "types": ["T044"], "canonical_name": "NADP-dependent 15-hydroxyprostaglandin dehydrogenase"}
{"concept_id": "C2250505", "aliases": ["NADP-linked 15-hydroxyprostaglandin dehydrogenase"], "types": ["T044"], "canonical_name": "NADP-linked 15-hydroxyprostaglandin dehydrogenase"}
{"concept_id": "C2250508", "aliases": ["NADP-specific 15-hydroxyprostaglandin dehydrogenase"], "types": ["T044"], "canonical_name": "NADP-specific 15-hydroxyprostaglandin dehydrogenase"}
{"concept_id": "C2250515", "aliases": [], "types": ["T044"], "canonical_name": "3(17)alpha-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C2250516", "aliases": [], "types": ["T044"], "canonical_name": "3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity"}
{"concept_id": "C2250517", "aliases": [], "types": ["T044"], "canonical_name": "3-beta-HSD activity"}
{"concept_id": "C2250518", "aliases": [], "types": ["T044"], "canonical_name": "3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity"}
{"concept_id": "C2250519", "aliases": [], "types": ["T044"], "canonical_name": "3beta,20alpha-hydroxysteroid oxidoreductase activity"}
{"concept_id": "C2250520", "aliases": [], "types": ["T044"], "canonical_name": "dehydrogenase, 3beta,20alpha-hydroxy steroid"}
{"concept_id": "C2250521", "aliases": ["progesterone reductase activity"], "types": ["T044"], "canonical_name": "progesterone reductase activity"}
{"concept_id": "C2250526", "aliases": [], "types": ["T044"], "canonical_name": "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)"}
{"concept_id": "C2250548", "aliases": [], "types": ["T044"], "canonical_name": "3alpha(17beta)-HSD"}
{"concept_id": "C2250550", "aliases": [], "types": ["T044"], "canonical_name": "3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity"}
{"concept_id": "C2250551", "aliases": [], "types": ["T044"], "canonical_name": "3alpha,17beta-hydroxy steroid dehydrogenase activity"}
{"concept_id": "C2250559", "aliases": [], "types": ["T044"], "canonical_name": "pteridine reductase 1 activity"}
{"concept_id": "C2250567", "aliases": ["3alpha-hydroxysteroid dehydrogenase (B-specific)", "androsterone dehydrogenase (B-specific) activity", "sterognost 3alpha", "hydroxyprostaglandin dehydrogenase activity", "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)", "3-alpha-HSD activity", "3-alpha-hydroxysteroid dehydrogenase (B-specific) activity", "3alpha-HSD"], "types": ["T044"], "definition": "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. [EC:1.1.1.50, MetaCyc:1.1.1.50-RXN]", "canonical_name": "3alpha-hydroxysteroid oxidoreductase activity"}
{"concept_id": "C2250571", "aliases": [], "types": ["T044"], "canonical_name": "(R)-20-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C2250572", "aliases": [], "types": ["T044"], "canonical_name": "20beta-HSD"}
{"concept_id": "C2250573", "aliases": [], "types": ["T044"], "canonical_name": "20beta-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C2250574", "aliases": [], "types": ["T044"], "canonical_name": "3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity"}
{"concept_id": "C2250575", "aliases": [], "types": ["T044"], "canonical_name": "3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity"}
{"concept_id": "C2250576", "aliases": [], "types": ["T044"], "canonical_name": "cortisone reductase activity"}
{"concept_id": "C2250577", "aliases": [], "types": ["T044"], "canonical_name": "dehydrogenase, 20beta-hydroxy steroid"}
{"concept_id": "C2250578", "aliases": [], "types": ["T044"], "canonical_name": "delta4-3-ketosteroid hydrogenase activity"}
{"concept_id": "C2250579", "aliases": [], "types": ["T044"], "canonical_name": "NADH-20beta-hydroxysteroid dehydrogenase activity"}
{"concept_id": "C2250580", "aliases": ["17-ketoreductase activity"], "types": ["T044"], "canonical_name": "17-ketoreductase activity"}
{"concept_id": "C2250594", "aliases": ["D-2-hydroxy fatty acid dehydrogenase activity", "(R)-2-hydroxy-fatty-acid dehydrogenase activity", "(R)-2-hydroxystearate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(R)-2-hydroxy-fatty acid dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH. [EC:1.1.1.98, RHEA:15949]"}
{"concept_id": "C2250595", "aliases": ["2-hydroxy fatty acid oxidase"], "types": ["T044"], "canonical_name": "2-hydroxy fatty acid oxidase"}
{"concept_id": "C2250599", "aliases": ["(S)-2-hydroxystearate:NAD+ oxidoreductase activity", "(S)-2-hydroxy-fatty-acid dehydrogenase activity", "dehydrogenase, L-2-hydroxy fatty acid", "L-2-hydroxy fatty acid dehydrogenase activity"], "types": ["T044"], "canonical_name": "(S)-2-hydroxy-fatty acid dehydrogenase activity", "definition": "Catalysis of the reaction: (S)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH. [EC:1.1.1.99, RHEA:11384]"}
{"concept_id": "C2250613", "aliases": [], "types": ["T044"], "canonical_name": "vitamin K1 epoxide reductase activity"}
{"concept_id": "C2250616", "aliases": ["polyvinyl-alcohol:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "polyvinyl-alcohol:(acceptor) oxidoreductase activity"}
{"concept_id": "C2250631", "aliases": [], "types": ["T044"], "canonical_name": "peroxidation-inhibiting protein activity"}
{"concept_id": "C2250635", "aliases": [], "types": ["T044"], "canonical_name": "membrane-bound hydrogenase activity"}
{"concept_id": "C2250636", "aliases": [], "types": ["T044"], "canonical_name": "quinone-reactive Ni/Fe-hydrogenase activity"}
{"concept_id": "C2250646", "aliases": [], "types": ["T044"], "canonical_name": "nonmetal hydrogenase activity"}
{"concept_id": "C2250656", "aliases": [], "types": ["T044"], "canonical_name": "steroid 4,5-dioxygenase activity"}
{"concept_id": "C2250675", "aliases": ["2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)"], "types": ["T044"], "canonical_name": "deoxyuridine 1'-dioxygenase activity", "definition": "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = 2-deoxy-D-ribono-1,4-lactone + CO(2) + succinate + uracil. [EC:1.14.11.10, RHEA:23316]"}
{"concept_id": "C2250678", "aliases": ["deoxyuridine 2'-hydroxylase activity", "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)"], "types": ["T044"], "canonical_name": "deoxyuridine 2'-dioxygenase activity", "definition": "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = CO(2) + succinate + uridine. [EC:1.14.11.3, RHEA:21076]"}
{"concept_id": "C2250683", "aliases": [], "types": ["T044"], "canonical_name": "thymidine 2'-dioxygenase activity"}
{"concept_id": "C2250684", "aliases": [], "types": ["T044"], "canonical_name": "thymidine 2'-hydroxylase activity"}
{"concept_id": "C2250685", "aliases": [], "types": ["T044"], "canonical_name": "thymidine 2-oxoglutarate dioxygenase activity"}
{"concept_id": "C2250686", "aliases": [], "types": ["T044"], "canonical_name": "thymidine dioxygenase activity"}
{"concept_id": "C2250737", "aliases": [], "types": ["T039"], "canonical_name": "regulation of cardiac contraction during acute phase response"}
{"concept_id": "C2250739", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of tissue kallikrein-kinin cascade"}
{"concept_id": "C2250740", "aliases": [], "types": ["T039"], "canonical_name": "activation of tissue kallikrein-kinin cascade"}
{"concept_id": "C2250741", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of tissue kallikrein-kinin cascade"}
{"concept_id": "C2250744", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of plasma kallikrein-kinin cascade"}
{"concept_id": "C2250745", "aliases": [], "types": ["T039"], "canonical_name": "activation of plasma kallikrein-kinin cascade"}
{"concept_id": "C2250746", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of plasma kallikrein-kinin cascade"}
{"concept_id": "C2250749", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antigen processing and presentation"}
{"concept_id": "C2250750", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation"}
{"concept_id": "C2250751", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antigen processing and presentation"}
{"concept_id": "C2250754", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"}
{"concept_id": "C2250755", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"}
{"concept_id": "C2250756", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"}
{"concept_id": "C2250759", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antigen processing and presentation of peptide antigen"}
{"concept_id": "C2250760", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation of peptide antigen"}
{"concept_id": "C2250761", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antigen processing and presentation of peptide antigen"}
{"concept_id": "C2250764", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antigen processing and presentation of peptide antigen via MHC class II"}
{"concept_id": "C2250765", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation of peptide antigen via MHC class II"}
{"concept_id": "C2250766", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antigen processing and presentation of peptide antigen via MHC class II"}
{"concept_id": "C2250769", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antigen processing and presentation of peptide antigen via MHC class I"}
{"concept_id": "C2250770", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation of peptide antigen via MHC class I"}
{"concept_id": "C2250771", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antigen processing and presentation of peptide antigen via MHC class I"}
{"concept_id": "C2250774", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antigen processing and presentation via MHC class Ib"}
{"concept_id": "C2250775", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation via MHC class Ib"}
{"concept_id": "C2250776", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antigen processing and presentation via MHC class Ib"}
{"concept_id": "C2250779", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib"}
{"concept_id": "C2250780", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation of peptide antigen via MHC class Ib"}
{"concept_id": "C2250781", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib"}
{"concept_id": "C2250805", "aliases": [], "types": ["T044"], "canonical_name": "fatty acyl-CoA reductase activity"}
{"concept_id": "C2250861", "aliases": [], "types": ["T044"], "canonical_name": "ketimine-reducing enzyme"}
{"concept_id": "C2250882", "aliases": ["protein disulfide reductase (NAD(P)H) activity", "protein disulfide-oxidoreductase activity", "protein disulphide oxidoreductase activity", "protein disulfide reductase activity", "disulfide reductase activity", "peptide disulphide oxidoreductase activity", "insulin-glutathione transhydrogenase activity", "NAD(P)H:protein-disulfide oxidoreductase activity", "protein-disulfide reductase (NAD(P)) activity", "peptide disulfide oxidoreductase activity", "protein disulfide oxidoreductase activity", "protein-disulphide reductase activity", "protein disulphide reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. [PMID:7559385]", "canonical_name": "protein-disulfide reductase activity"}
{"concept_id": "C2250886", "aliases": ["Bis-gamma-glutamylcystine reductase (NADPH)", "gamma-glutamylcysteine:NADP+ oxidoreductase activity", "NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity", "NADPH:bis-gamma-glutamylcysteine oxidoreductase activity", "bis-g-glutamylcystine reductase (NADPH) activity", "bis-gamma-glutamylcystine reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH. [EC:1.8.1.13, RHEA:11980]", "canonical_name": "bis-gamma-glutamylcystine reductase (NADPH) activity"}
{"concept_id": "C2250922", "aliases": [], "types": ["T044"], "canonical_name": "chlorate reductase C"}
{"concept_id": "C2250927", "aliases": [], "types": ["T044"], "canonical_name": "O-methyltransferase I"}
{"concept_id": "C2250929", "aliases": [], "types": ["T044"], "canonical_name": "O-methyltransferase II activity"}
{"concept_id": "C2250957", "aliases": [], "types": ["T044"], "canonical_name": "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate"}
{"concept_id": "C2250969", "aliases": [], "types": ["T044"], "canonical_name": "acyl-protein synthase activity"}
{"concept_id": "C2251038", "aliases": ["sialate O-acetyltransferase"], "types": ["T044"], "canonical_name": "sialate O-acetyltransferase"}
{"concept_id": "C2251072", "aliases": [], "types": ["T044"], "canonical_name": "blood platelet-activating factor acetyltransferase activity"}
{"concept_id": "C2251073", "aliases": [], "types": ["T044"], "canonical_name": "lyso-GPC:acetyl CoA acetyltransferase activity"}
{"concept_id": "C2251074", "aliases": ["lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity"], "types": ["T044"], "canonical_name": "lyso-platelet activating factor:acetyl-CoA acetyltransferase activity"}
{"concept_id": "C2251076", "aliases": [], "types": ["T044"], "canonical_name": "platelet-activating factor acylhydrolase activity"}
{"concept_id": "C2251077", "aliases": [], "types": ["T044"], "canonical_name": "platelet-activating factor-synthesizing enzyme activity"}
{"concept_id": "C2251086", "aliases": [], "types": ["T044"], "canonical_name": "wax synthase activity"}
{"concept_id": "C2251161", "aliases": [], "types": ["T044"], "canonical_name": "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase"}
{"concept_id": "C2251164", "aliases": [], "types": ["T044"], "canonical_name": "water-soluble-glucan synthase activity"}
{"concept_id": "C2251172", "aliases": [], "types": ["T044"], "canonical_name": "galactosyltransferase II activity"}
{"concept_id": "C2251193", "aliases": [], "types": ["T044"], "canonical_name": "core 6-beta-GalNAc-transferase B activity"}
{"concept_id": "C2251194", "aliases": [], "types": ["T044"], "canonical_name": "core 6beta-GalNAc-transferase B"}
{"concept_id": "C2251197", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B"}
{"concept_id": "C2251219", "aliases": ["uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase"], "types": ["T044"], "canonical_name": "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase"}
{"concept_id": "C2251233", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I"}
{"concept_id": "C2251291", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylglucosaminyltransferase VI activity"}
{"concept_id": "C2251293", "aliases": ["mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity", "UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity", "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity", "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI", "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity", "alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity"], "types": ["T044"], "canonical_name": "alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP. [EC:2.4.1.201, MetaCyc:2.4.1.201-RXN]"}
{"concept_id": "C2251359", "aliases": [], "types": ["T044"], "canonical_name": "beta3GalNAc-T1"}
{"concept_id": "C2251376", "aliases": [], "types": ["T044"], "canonical_name": "alpha-galactosyltransferase activity"}
{"concept_id": "C2251415", "aliases": ["mono(ADP-ribosyl)transferase activity"], "types": ["T044"], "canonical_name": "mono(ADP-ribosyl)transferase activity"}
{"concept_id": "C2251417", "aliases": ["CMP-acetylneuraminate-lactosylceramide-sialyltransferase"], "types": ["T044"], "canonical_name": "CMP-acetylneuraminate-lactosylceramide-sialyltransferase"}
{"concept_id": "C2251421", "aliases": ["cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase"], "types": ["T044"], "canonical_name": "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase"}
{"concept_id": "C2251429", "aliases": [], "types": ["T044"], "canonical_name": "sialyltransferase 3C activity"}
{"concept_id": "C2251430", "aliases": [], "types": ["T044"], "canonical_name": "sialyltransferase 7D activity"}
{"concept_id": "C2251455", "aliases": [], "types": ["T044"], "canonical_name": "geranylgeranyltransferase II"}
{"concept_id": "C2251468", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxamine-pyruvic transaminase"}
{"concept_id": "C2251511", "aliases": ["phenylalanine(histidine):pyruvate aminotransferase activity", "L-phenylalanine:pyruvate transaminase activity", "histidine:pyruvate aminotransferase activity", "L-phenylalanine(L-histidine):pyruvate aminotransferase activity", "L-histidine:pyruvate aminotransferase activity", "phenylalanine (histidine) aminotransferase activity", "phenylalanine(histidine) aminotransferase activity", "phenylalanine(histidine) transaminase activity"], "types": ["T044"], "canonical_name": "L-phenylalanine:pyruvate aminotransferase activity", "definition": "Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine. [EC:2.6.1.58, MetaCyc:2.6.1.58-RXN]"}
{"concept_id": "C2251514", "aliases": [], "types": ["T044"], "canonical_name": "glutamine transaminase K activity"}
{"concept_id": "C2251522", "aliases": [], "types": ["T044"], "canonical_name": "diphosphate:microsomal-membrane-protein O-phosphotransferase activity"}
{"concept_id": "C2251535", "aliases": ["reductase kinase activity"], "types": ["T044"], "canonical_name": "reductase kinase activity"}
{"concept_id": "C2251537", "aliases": ["1D-myo-inositol-trisphosphate 5-kinase activity"], "types": ["T044"], "canonical_name": "1D-myo-inositol-trisphosphate 5-kinase activity"}
{"concept_id": "C2251538", "aliases": ["1D-myo-inositol-trisphosphate 6-kinase activity"], "types": ["T044"], "canonical_name": "1D-myo-inositol-trisphosphate 6-kinase activity"}
{"concept_id": "C2251541", "aliases": ["inositol-trisphosphate 5-kinase activity", "IP3 5-kinase activity"], "types": ["T044"], "canonical_name": "inositol-trisphosphate 5-kinase activity"}
{"concept_id": "C2251542", "aliases": ["inositol trisphosphate 6-kinase activity", "inositol-trisphosphate 6-kinase activity"], "types": ["T044"], "canonical_name": "inositol-trisphosphate 6-kinase activity"}
{"concept_id": "C2251581", "aliases": [], "types": ["T044"], "canonical_name": "GDP hexose pyrophosphorylase activity"}
{"concept_id": "C2251582", "aliases": [], "types": ["T044"], "canonical_name": "GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity"}
{"concept_id": "C2251583", "aliases": [], "types": ["T044"], "canonical_name": "guanosine diphosphohexose pyrophosphorylase activity"}
{"concept_id": "C2251620", "aliases": [], "types": ["T044"], "canonical_name": "sugar-1-phosphate adenylyltransferase activity"}
{"concept_id": "C2251629", "aliases": [], "types": ["T044"], "canonical_name": "sugar-1-phosphate nucleotidyltransferase activity"}
{"concept_id": "C2251635", "aliases": [], "types": ["T044"], "canonical_name": "Gro-PCT"}
{"concept_id": "C2251658", "aliases": ["teichoic-acid synthase activity"], "types": ["T044"], "canonical_name": "teichoic-acid synthase activity"}
{"concept_id": "C2251724", "aliases": [], "types": ["T044"], "canonical_name": "esterase D activity"}
{"concept_id": "C2251728", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-retinyl-palmitate acylhydrolase activity"}
{"concept_id": "C2251735", "aliases": [], "types": ["T044"], "canonical_name": "ADP-dependent propionyl-CoA thioesterase activity"}
{"concept_id": "C2251739", "aliases": ["medium-chain acyl coenzyme A hydrolase activity", "medium-chain-acyl-CoA hydrolase activity", "medium-chain acyl-thioester hydrolase activity", "medium-chain hydrolase activity"], "types": ["T044"], "canonical_name": "medium-chain acyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length. [EC:3.1.2.19]"}
{"concept_id": "C2251743", "aliases": [], "types": ["T044"], "canonical_name": "ADP-dependent myristoyl-CoA thioesterase activity"}
{"concept_id": "C2251745", "aliases": [], "types": ["T044"], "canonical_name": "dodecyl-acyl-carrier protein hydrolase"}
{"concept_id": "C2251750", "aliases": [], "types": ["T044"], "canonical_name": "reductase phosphatase activity"}
{"concept_id": "C2251769", "aliases": [], "types": ["T044"], "canonical_name": "lysophospholipase D activity"}
{"concept_id": "C2251789", "aliases": [], "types": ["T044"], "canonical_name": "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]"}
{"concept_id": "C2251792", "aliases": [], "types": ["T044"], "canonical_name": "glycosylphosphatidylinositol-phospholipase C activity"}
{"concept_id": "C2251807", "aliases": [], "types": ["T044"], "canonical_name": "oligosaccharide lacto-N-biosylhydrolase activity"}
{"concept_id": "C2251818", "aliases": [], "types": ["T044"], "canonical_name": "azoferredoxin-activating enzymes"}
{"concept_id": "C2251828", "aliases": [], "types": ["T044"], "canonical_name": "nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV"}
{"concept_id": "C2251840", "aliases": [], "types": ["T044"], "canonical_name": "o-phthalyl amidase activity"}
{"concept_id": "C2251875", "aliases": [], "types": ["T044"], "canonical_name": "3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]"}
{"concept_id": "C2251891", "aliases": [], "types": ["T044"], "canonical_name": "2-keto-3-deoxy-L-arabonate aldolase activity"}
{"concept_id": "C2251893", "aliases": [], "types": ["T044"], "canonical_name": "3-deoxy-D-pentulosonic acid aldolase"}
{"concept_id": "C2251960", "aliases": [], "types": ["T044"], "canonical_name": "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)"}
{"concept_id": "C2251961", "aliases": ["reduced nicotinamide adenine dinucleotide hydrate dehydratase activity"], "types": ["T044"], "canonical_name": "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity"}
{"concept_id": "C2251968", "aliases": [], "types": ["T044"], "canonical_name": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]"}
{"concept_id": "C2251973", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1,4-glucan lyase activity"}
{"concept_id": "C2251991", "aliases": [], "types": ["T044"], "canonical_name": "gramicidin S synthetase I"}
{"concept_id": "C2252015", "aliases": [], "types": ["T044"], "canonical_name": "(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase"}
{"concept_id": "C2252026", "aliases": [], "types": ["T044"], "canonical_name": "D-alanine-activating enzyme activity"}
{"concept_id": "C2252030", "aliases": [], "types": ["T044"], "canonical_name": "acyl-protein synthetase activity"}
{"concept_id": "C2252031", "aliases": ["long-chain-fatty-acid:protein ligase (AMP-forming)", "long-chain-fatty-acid luciferin component ligase activity", "long-chain-fatty-acid-luciferin-component ligase activity"], "types": ["T044"], "canonical_name": "long-chain fatty acid luciferin component ligase activity", "definition": "Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [EC:6.2.1.19, MetaCyc:6.2.1.19-RXN]"}
{"concept_id": "C2252044", "aliases": [], "types": ["T044"], "canonical_name": "MurF synthetase activity"}
{"concept_id": "C2252058", "aliases": [], "types": ["T044"], "canonical_name": "L-lysine-adding enzyme activity"}
{"concept_id": "C2252059", "aliases": ["MurE synthetase activity"], "types": ["T044"], "canonical_name": "MurE synthetase activity"}
{"concept_id": "C2252068", "aliases": [], "types": ["T044"], "canonical_name": "heparin eliminase activity"}
{"concept_id": "C2252071", "aliases": [], "types": ["T044"], "canonical_name": "exo-PATE"}
{"concept_id": "C2252073", "aliases": [], "types": ["T044"], "canonical_name": "exo-PGL"}
{"concept_id": "C2252089", "aliases": [], "types": ["T044"], "canonical_name": "alginase II activity"}
{"concept_id": "C2252103", "aliases": [], "types": ["T044"], "canonical_name": "periplasmic phosphoglycerotransferase activity"}
{"concept_id": "C2252104", "aliases": [], "types": ["T044"], "canonical_name": "phosphoglycerol cyclase activity"}
{"concept_id": "C2252108", "aliases": ["monoterpenoid dehydrogenase activity"], "types": ["T044"], "canonical_name": "monoterpenoid dehydrogenase activity"}
{"concept_id": "C2252143", "aliases": [], "types": ["T044"], "canonical_name": "almond emulsin fucosidase II activity"}
{"concept_id": "C2252146", "aliases": [], "types": ["T044"], "canonical_name": "laminarin phosphorylase activity"}
{"concept_id": "C2252162", "aliases": ["quinate:quinone 3-oxidoreductase activity", "NAD(P)-independent quinate dehydrogenase activity", "quinate:pyrroloquinoline-quinone 5-oxidoreductase activity"], "types": ["T044"], "canonical_name": "quinate dehydrogenase (quinone) activity", "definition": "Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol. [RHEA:23672]"}
{"concept_id": "C2252167", "aliases": [], "types": ["T044"], "canonical_name": "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity"}
{"concept_id": "C2252168", "aliases": [], "types": ["T044"], "canonical_name": "12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity"}
{"concept_id": "C2252170", "aliases": ["15-oxoprostaglandin 13-reductase activity", "15-ketoprostaglandin delta13-reductase activity", "prostaglandin delta13-reductase activity", "15-oxo-delta13-prostaglandin reductase activity", "prostaglandin 13-reductase activity", "delta13-15-ketoprostaglandin reductase activity"], "types": ["T044"], "canonical_name": "13-prostaglandin reductase activity", "definition": "Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin. [EC:1.3.1.48, GOC:mw, KEGG_REACTION:R04556, KEGG_REACTION:R04557, PMID:17449869]"}
{"concept_id": "C2252198", "aliases": ["2-oxoglutarate semialdehyde dehydrogenase activity", "2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity", "alpha-ketoglutaric semialdehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "2,5-dioxovalerate dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+. [EC:1.2.1.26, MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN]"}
{"concept_id": "C2252202", "aliases": [], "types": ["T044"], "canonical_name": "acetohydroxy acid isomerase activity"}
{"concept_id": "C2252233", "aliases": [], "types": ["T044"], "canonical_name": "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)"}
{"concept_id": "C2252239", "aliases": [], "types": ["T044"], "canonical_name": "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase"}
{"concept_id": "C2252242", "aliases": [], "types": ["T044"], "canonical_name": "(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]"}
{"concept_id": "C2252249", "aliases": [], "types": ["T044"], "canonical_name": "nitrophenol oxygenase activity"}
{"concept_id": "C2252253", "aliases": ["2-ketoaldehyde dehydrogenase"], "types": ["T044"], "canonical_name": "2-ketoaldehyde dehydrogenase"}
{"concept_id": "C2252255", "aliases": ["alpha-ketoaldehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "alpha-ketoaldehyde dehydrogenase activity"}
{"concept_id": "C2252256", "aliases": ["methylglyoxal dehydrogenase activity"], "types": ["T044"], "canonical_name": "methylglyoxal dehydrogenase activity"}
{"concept_id": "C2252271", "aliases": [], "types": ["T044"], "canonical_name": "cGMP-PDE"}
{"concept_id": "C2252295", "aliases": [], "types": ["T044"], "canonical_name": "KTS reductase activity"}
{"concept_id": "C2252305", "aliases": ["3-hydroxypropanoate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "3-hydroxypropionate dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: 3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH. [EC:1.1.1.59, RHEA:13357]"}
{"concept_id": "C2252307", "aliases": [], "types": ["T044"], "canonical_name": "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]"}
{"concept_id": "C2252360", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]"}
{"concept_id": "C2252417", "aliases": [], "types": ["T044"], "canonical_name": "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]"}
{"concept_id": "C2252431", "aliases": [], "types": ["T044"], "canonical_name": "N(8)-acetylspermidine deacetylase activity"}
{"concept_id": "C2252432", "aliases": [], "types": ["T044"], "canonical_name": "N(8)-monoacetylspermidine deacetylase activity"}
{"concept_id": "C2252433", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylspermidine deacetylase activity"}
{"concept_id": "C2252444", "aliases": [], "types": ["T044"], "canonical_name": "aconitate isomerase activity"}
{"concept_id": "C2252451", "aliases": [], "types": ["T044"], "canonical_name": "thioesterase B"}
{"concept_id": "C2252452", "aliases": [], "types": ["T044"], "canonical_name": "thioesterase II"}
{"concept_id": "C2252493", "aliases": ["agmatine amidinohydrolase"], "types": ["T044"], "canonical_name": "agmatine amidinohydrolase"}
{"concept_id": "C2252497", "aliases": [], "types": ["T044"], "canonical_name": "phosphagen phosphokinase activity"}
{"concept_id": "C2252534", "aliases": [], "types": ["T044"], "canonical_name": "polyethylene glycol dehydrogenase activity"}
{"concept_id": "C2252535", "aliases": [], "types": ["T044"], "canonical_name": "aldehyde monooxygenase activity"}
{"concept_id": "C2252553", "aliases": [], "types": ["T044"], "canonical_name": "halogenase activity"}
{"concept_id": "C2252577", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA:kanamycin-B N6'-acetyltransferase activity"}
{"concept_id": "C2252610", "aliases": ["amygdalinase"], "types": ["T044"], "canonical_name": "amygdalinase"}
{"concept_id": "C2252627", "aliases": [], "types": ["T044"], "canonical_name": "8-lipoxygenase activity"}
{"concept_id": "C2252641", "aliases": [], "types": ["T044"], "canonical_name": "veratryl alcohol oxidase activity"}
{"concept_id": "C2252679", "aliases": [], "types": ["T044"], "canonical_name": "adrenergic receptor kinase activity"}
{"concept_id": "C2252680", "aliases": [], "types": ["T044"], "canonical_name": "ATP:beta-adrenergic-receptor phosphotransferase activity"}
{"concept_id": "C2252683", "aliases": [], "types": ["T044"], "canonical_name": "beta-adrenoceptor kinase 1 activity"}
{"concept_id": "C2252684", "aliases": [], "types": ["T044"], "canonical_name": "beta-adrenoceptor kinase 2 activity"}
{"concept_id": "C2252687", "aliases": ["beta-ARK 1"], "types": ["T044"], "canonical_name": "betaARK1"}
{"concept_id": "C2252688", "aliases": [], "types": ["T044"], "canonical_name": "beta-ARK 2"}
{"concept_id": "C2252690", "aliases": [], "types": ["T044"], "canonical_name": "beta2ARK"}
{"concept_id": "C2252706", "aliases": ["BAST I activity"], "types": ["T044"], "canonical_name": "bile acid sulfotransferase I activity"}
{"concept_id": "C2252708", "aliases": [], "types": ["T044"], "canonical_name": "glycolithocholate sulfotransferase activity"}
{"concept_id": "C2252709", "aliases": [], "types": ["T044"], "canonical_name": "bilirubin oxidase M-1"}
{"concept_id": "C2252750", "aliases": [], "types": ["T044"], "canonical_name": "(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]"}
{"concept_id": "C2252795", "aliases": [], "types": ["T044"], "canonical_name": "CDH activity"}
{"concept_id": "C2252796", "aliases": [], "types": ["T044"], "canonical_name": "cellobiose dehydrogenase (quinone) activity"}
{"concept_id": "C2252799", "aliases": [], "types": ["T044"], "canonical_name": "cellobiose-quinone oxidoreductase activity"}
{"concept_id": "C2252825", "aliases": ["bile acid coenzyme A ligase activity", "BAL activity"], "types": ["T044"], "canonical_name": "bile acid CoA ligase activity"}
{"concept_id": "C2252834", "aliases": [], "types": ["T044"], "canonical_name": "THCA-CoA ligase activity"}
{"concept_id": "C2252835", "aliases": [], "types": ["T044"], "canonical_name": "trihydroxycoprostanoyl-CoA synthetase activity"}
{"concept_id": "C2252843", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol 27-hydroxylase activity"}
{"concept_id": "C2252844", "aliases": [], "types": ["T044"], "canonical_name": "CYP27A1"}
{"concept_id": "C2252845", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 27A1' activity"}
{"concept_id": "C2252846", "aliases": [], "types": ["T044"], "canonical_name": "sterol 26-hydroxylase activity"}
{"concept_id": "C2252847", "aliases": [], "types": ["T044"], "canonical_name": "sterol 27-hydroxylase activity"}
{"concept_id": "C2252851", "aliases": ["3-oxosteroid delta4-dehydrogenase"], "types": ["T044"], "canonical_name": "3-oxosteroid delta4-dehydrogenase"}
{"concept_id": "C2252854", "aliases": ["5alpha-reductase"], "types": ["T044"], "canonical_name": "5alpha-reductase"}
{"concept_id": "C2252859", "aliases": ["testosterone 5alpha-reductase"], "types": ["T044"], "canonical_name": "testosterone 5alpha-reductase"}
{"concept_id": "C2252871", "aliases": [], "types": ["T044"], "canonical_name": "polyglucuronate 5-epimerase activity"}
{"concept_id": "C2252873", "aliases": ["ATP:isobutyrate 1-phosphotransferase activity", "ATP:2-methylpropanoate 1-phosphotransferase activity", "ATP:2-methylpropanoate kinase activity", "ATP:branched-chain-fatty-acid 1-phosphotransferase activity"], "types": ["T044"], "canonical_name": "ATP:2-methylpropanoate phosphotransferase activity", "definition": "Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H(+). [EC:2.7.2.14, RHEA:24156]"}
{"concept_id": "C2252874", "aliases": [], "types": ["T044"], "canonical_name": "isobutyrate kinase activity"}
{"concept_id": "C2252919", "aliases": [], "types": ["T044"], "canonical_name": "citramalic-condensing enzyme"}
{"concept_id": "C2252930", "aliases": ["citrate hydro-lyase activity"], "types": ["T044"], "canonical_name": "citrate hydro-lyase activity"}
{"concept_id": "C2252937", "aliases": [], "types": ["T044"], "canonical_name": "corticosterone methyl oxidase activity"}
{"concept_id": "C2252945", "aliases": [], "types": ["T044"], "canonical_name": "glucocorticosteroid sulfotransferase activity"}
{"concept_id": "C2252949", "aliases": [], "types": ["T044"], "canonical_name": "delta4-3-oxosteroid-5alpha-reductase"}
{"concept_id": "C2252964", "aliases": [], "types": ["T044"], "canonical_name": "UGT85B1 activity"}
{"concept_id": "C2252987", "aliases": [], "types": ["T044"], "canonical_name": "persulfurase activity"}
{"concept_id": "C2252989", "aliases": ["L-cysteine transaminase activity", "cysteine transaminase activity", "cysteine aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate. [RHEA:17441]", "canonical_name": "L-cysteine:2-oxoglutarate aminotransferase activity"}
{"concept_id": "C2253006", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome hydrogenase activity"}
{"concept_id": "C2253018", "aliases": ["D-alanine-D-glutamate transaminase activity", "D-alanine transaminase activity", "D-alanine aminotransferase activity"], "types": ["T044"], "canonical_name": "D-alanine:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate. [EC:2.6.1.21, MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN]"}
{"concept_id": "C2253019", "aliases": [], "types": ["T044"], "canonical_name": "D-amino acid aminotransferase activity"}
{"concept_id": "C2253020", "aliases": ["D-amino-acid transaminase activity"], "types": ["T044"], "canonical_name": "D-amino acid transaminase activity"}
{"concept_id": "C2253021", "aliases": [], "types": ["T044"], "canonical_name": "D-aspartate aminotransferase activity"}
{"concept_id": "C2253022", "aliases": [], "types": ["T044"], "canonical_name": "D-aspartate transaminase activity"}
{"concept_id": "C2253023", "aliases": [], "types": ["T044"], "canonical_name": "D-aspartic aminotransferase activity"}
{"concept_id": "C2253033", "aliases": ["D-arabinose:NAD+ 1-oxidoreductase activity", "arabinose(fucose)dehydrogenase activity", "NAD-pentose-dehydrogenase activity"], "types": ["T044"], "canonical_name": "D-arabinose 1-dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH. [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN]"}
{"concept_id": "C2253064", "aliases": ["D-nopaline dehydrogenase activity", "NOS activity", "2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)", "N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)", "D-nopaline synthase activity", "nopaline synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH. [EC:1.5.1.19, MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN]", "canonical_name": "nopaline dehydrogenase activity"}
{"concept_id": "C2253091", "aliases": [], "types": ["T044"], "canonical_name": "NAD-D-xylose"}
{"concept_id": "C2253092", "aliases": ["NAD-linked D-xylose dehydrogenase activity", "(NAD)-linked D-xylose dehydrogenase activity", "D-xylose:NAD+ 1-oxidoreductase activity", "D-xylose dehydrogenase activity", "NAD-D-xylose dehydrogenase activity"], "types": ["T044"], "canonical_name": "D-xylose 1-dehydrogenase (NAD) activity", "definition": "Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH. [EC:1.1.1.175, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN]"}
{"concept_id": "C2253168", "aliases": [], "types": ["T044"], "canonical_name": "microsomal oxidase II"}
{"concept_id": "C2253183", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas"}
{"concept_id": "C2253225", "aliases": ["hexadecanoate:hydrogen-peroxide oxidoreductase activity", "long chain fatty acid peroxidase activity", "fatty-acid peroxidase activity"], "types": ["T044"], "canonical_name": "fatty acid peroxidase activity", "definition": "Catalysis of the reaction: 2 H(2)O(2) + H(+) + palmitate = CO(2) + 3 H(2)O + pentadecanal. [EC:1.11.1.3, RHEA:23960]"}
{"concept_id": "C2253228", "aliases": ["assimilatory nitrate reductase activity"], "types": ["T044"], "canonical_name": "assimilatory nitrate reductase activity"}
{"concept_id": "C2253317", "aliases": [], "types": ["T044"], "canonical_name": "aminoglycoside 2'-N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H(+). This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring. [EC:2.3.1.59, RHEA:24516]"}
{"concept_id": "C2253318", "aliases": ["acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity"], "types": ["T044"], "canonical_name": "acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity"}
{"concept_id": "C2253319", "aliases": [], "types": ["T044"], "canonical_name": "gentamicin acetyltransferase II activity"}
{"concept_id": "C2253320", "aliases": [], "types": ["T044"], "canonical_name": "gentamycin acetyltransferase II"}
{"concept_id": "C2253373", "aliases": ["D-glucose dehydrogenase (NAD(P))", "hexose phosphate dehydrogenase activity", "beta-D-glucose:NAD(P)+ 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "glucose 1-dehydrogenase [NAD(P)] activity", "definition": "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H. [EC:1.1.1.47]"}
{"concept_id": "C2253380", "aliases": [], "types": ["T044"], "canonical_name": "aldehyde reductase II activity"}
{"concept_id": "C2253382", "aliases": [], "types": ["T044"], "canonical_name": "D-glucuronate reductase activity"}
{"concept_id": "C2253397", "aliases": [], "types": ["T044"], "canonical_name": "gamma-glutaminyltransferase activity"}
{"concept_id": "C2253398", "aliases": [], "types": ["T044"], "canonical_name": "glutaminase II activity"}
{"concept_id": "C2253399", "aliases": [], "types": ["T044"], "canonical_name": "glutamine transaminase activity"}
{"concept_id": "C2253400", "aliases": [], "types": ["T044"], "canonical_name": "glutamine transaminase L activity"}
{"concept_id": "C2253401", "aliases": [], "types": ["T044"], "canonical_name": "glutamine--oxo-acid transaminase activity"}
{"concept_id": "C2253402", "aliases": [], "types": ["T044"], "canonical_name": "glutamine-alpha-keto acid transamidase activity"}
{"concept_id": "C2253403", "aliases": [], "types": ["T044"], "canonical_name": "glutamine-alpha-keto acid transaminase activity"}
{"concept_id": "C2253404", "aliases": [], "types": ["T044"], "canonical_name": "glutamine-keto acid aminotransferase activity"}
{"concept_id": "C2253405", "aliases": [], "types": ["T044"], "canonical_name": "glutamine-oxo acid aminotransferase activity"}
{"concept_id": "C2253406", "aliases": [], "types": ["T044"], "canonical_name": "L-glutamine transaminase L"}
{"concept_id": "C2253407", "aliases": [], "types": ["T044"], "canonical_name": "L-glutamine:pyruvate aminotransferase activity", "definition": "Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine. [EC:2.6.1.15, RHEA:10400]"}
{"concept_id": "C2253434", "aliases": ["formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)"], "types": ["T044"], "canonical_name": "4'-methoxyisoflavone 2'-hydroxylase activity", "definition": "Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O. [EC:1.14.14.89, MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN]"}
{"concept_id": "C2253437", "aliases": ["glutamate-glyoxylate transaminase activity", "L-glutamate:glyoxylate aminotransferase activity", "glyoxylate-glutamate aminotransferase activity", "glyoxylate-glutamic transaminase activity", "glutamic-glyoxylic transaminase activity"], "types": ["T044"], "canonical_name": "glycine:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate. [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN]"}
{"concept_id": "C2253468", "aliases": ["glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA. [EC:1.2.1.17, RHEA:21024]", "canonical_name": "glyoxylate dehydrogenase (acylating) activity"}
{"concept_id": "C2253491", "aliases": [], "types": ["T044"], "canonical_name": "hepoxilin A(3) hydrolase activity"}
{"concept_id": "C2253493", "aliases": [], "types": ["T044"], "canonical_name": "hepoxylin hydrolase activity"}
{"concept_id": "C2253508", "aliases": ["bidirectional hydrogenase activity"], "types": ["T044"], "canonical_name": "bidirectional hydrogenase activity"}
{"concept_id": "C2253515", "aliases": [], "types": ["T044"], "canonical_name": "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]"}
{"concept_id": "C2253518", "aliases": [], "types": ["T044"], "canonical_name": "linoleate hydroperoxide isomerase"}
{"concept_id": "C2253519", "aliases": [], "types": ["T044"], "canonical_name": "linoleic acid hydroperoxide isomerase"}
{"concept_id": "C2253538", "aliases": [], "types": ["T044"], "canonical_name": "L-2-hydroxyphytanate:oxygen 2-oxidoreductase"}
{"concept_id": "C2253555", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of melanin biosynthetic process"}
{"concept_id": "C2253556", "aliases": [], "types": ["T044"], "canonical_name": "activation of melanin biosynthetic process"}
{"concept_id": "C2253557", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of melanin biosynthetic process"}
{"concept_id": "C2253559", "aliases": ["downregulation of nuclear mRNA splicing, via spliceosome", "negative regulation of nuclear mRNA splicing, via spliceosome", "down regulation of nuclear mRNA splicing, via spliceosome", "down-regulation of nuclear mRNA splicing, via spliceosome"], "types": ["T045"], "canonical_name": "negative regulation of mRNA splicing, via spliceosome", "definition": "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. [GOC:jid]"}
{"concept_id": "C2253560", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of nuclear mRNA splicing, via spliceosome"}
{"concept_id": "C2253561", "aliases": [], "types": ["T045"], "canonical_name": "activation of nuclear mRNA splicing, via spliceosome"}
{"concept_id": "C2253562", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of nuclear mRNA splicing, via spliceosome"}
{"concept_id": "C2253563", "aliases": ["up-regulation of nuclear mRNA splicing, via spliceosome", "up regulation of nuclear mRNA splicing, via spliceosome", "upregulation of nuclear mRNA splicing, via spliceosome", "positive regulation of nuclear mRNA splicing, via spliceosome"], "types": ["T045"], "canonical_name": "positive regulation of mRNA splicing, via spliceosome", "definition": "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. [GOC:jid]"}
{"concept_id": "C2253579", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of cuticle pigmentation"}
{"concept_id": "C2253580", "aliases": [], "types": ["T042"], "canonical_name": "activation of cuticle pigmentation"}
{"concept_id": "C2253581", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of cuticle pigmentation"}
{"concept_id": "C2253583", "aliases": [], "types": ["T040"], "canonical_name": "regulation of adult chitin-containing cuticle pigmentation", "definition": "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C2253584", "aliases": ["down regulation of adult chitin-containing cuticle pigmentation", "downregulation of adult chitin-containing cuticle pigmentation", "down-regulation of adult chitin-containing cuticle pigmentation"], "types": ["T042"], "canonical_name": "negative regulation of adult chitin-containing cuticle pigmentation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C2253585", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of adult chitin-containing cuticle pigmentation"}
{"concept_id": "C2253586", "aliases": ["upregulation of adult chitin-containing cuticle pigmentation", "up regulation of adult chitin-containing cuticle pigmentation", "up-regulation of adult chitin-containing cuticle pigmentation"], "types": ["T040"], "canonical_name": "positive regulation of adult chitin-containing cuticle pigmentation", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C2253587", "aliases": [], "types": ["T040"], "canonical_name": "activation of adult chitin-containing cuticle pigmentation"}
{"concept_id": "C2253588", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of adult chitin-containing cuticle pigmentation"}
{"concept_id": "C2253589", "aliases": ["adult cuticle pigmentation"], "types": ["T042"], "canonical_name": "adult chitin-containing cuticle pigmentation", "definition": "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster. [GOC:jid, GOC:mtg_sensu]"}
{"concept_id": "C2253591", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of pigmentation"}
{"concept_id": "C2253596", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of female pigmentation"}
{"concept_id": "C2253597", "aliases": [], "types": ["T040"], "canonical_name": "activation of female pigmentation"}
{"concept_id": "C2253598", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of female pigmentation"}
{"concept_id": "C2253601", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of male pigmentation"}
{"concept_id": "C2253602", "aliases": [], "types": ["T040"], "canonical_name": "activation of male pigmentation"}
{"concept_id": "C2253603", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of male pigmentation"}
{"concept_id": "C2253605", "aliases": [], "types": ["T043"], "canonical_name": "activation of fibroblast proliferation"}
{"concept_id": "C2253606", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of fibroblast proliferation"}
{"concept_id": "C2253609", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fibroblast proliferation"}
{"concept_id": "C2253610", "aliases": [], "types": ["T042"], "canonical_name": "activation of long-term neuronal synaptic plasticity"}
{"concept_id": "C2253611", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of long-term neuronal synaptic plasticity"}
{"concept_id": "C2253614", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of long-term neuronal synaptic plasticity"}
{"concept_id": "C2253615", "aliases": [], "types": ["T042"], "canonical_name": "activation of short-term neuronal synaptic plasticity"}
{"concept_id": "C2253616", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of short-term neuronal synaptic plasticity"}
{"concept_id": "C2253619", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of short-term neuronal synaptic plasticity"}
{"concept_id": "C2253625", "aliases": [], "types": ["T043"], "canonical_name": "activation of Golgi vesicle fusion to target membrane"}
{"concept_id": "C2253626", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of Golgi vesicle fusion to target membrane"}
{"concept_id": "C2253629", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Golgi vesicle fusion to target membrane"}
{"concept_id": "C2253635", "aliases": [], "types": ["T044"], "canonical_name": "lactase-phlorizin hydrolase"}
{"concept_id": "C2253641", "aliases": [], "types": ["T044"], "canonical_name": "L-ornithine transmembrane transporter activity", "definition": "Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2253642", "aliases": ["sulphur amino acid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "sulfur amino acid transmembrane transporter activity", "definition": "Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2253643", "aliases": [], "types": ["T044"], "canonical_name": "L-methionine secondary active transmembrane transporter activity", "definition": "Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]"}
{"concept_id": "C2253650", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib"}
{"concept_id": "C2253651", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation of lipid antigen via MHC class Ib"}
{"concept_id": "C2253652", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib"}
{"concept_id": "C2253655", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II"}
{"concept_id": "C2253656", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation of polysaccharide antigen via MHC class II"}
{"concept_id": "C2253657", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II"}
{"concept_id": "C2253660", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dendritic cell antigen processing and presentation"}
{"concept_id": "C2253661", "aliases": [], "types": ["T043"], "canonical_name": "activation of dendritic cell antigen processing and presentation"}
{"concept_id": "C2253662", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of dendritic cell antigen processing and presentation"}
{"concept_id": "C2253665", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myeloid dendritic cell antigen processing and presentation"}
{"concept_id": "C2253666", "aliases": [], "types": ["T043"], "canonical_name": "activation of myeloid dendritic cell antigen processing and presentation"}
{"concept_id": "C2253667", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of myeloid dendritic cell antigen processing and presentation"}
{"concept_id": "C2253670", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of plasmacytoid dendritic cell antigen processing and presentation"}
{"concept_id": "C2253671", "aliases": [], "types": ["T043"], "canonical_name": "activation of plasmacytoid dendritic cell antigen processing and presentation"}
{"concept_id": "C2253672", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of plasmacytoid dendritic cell antigen processing and presentation"}
{"concept_id": "C2253675", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of monocyte antigen processing and presentation"}
{"concept_id": "C2253676", "aliases": [], "types": ["T043"], "canonical_name": "activation of monocyte antigen processing and presentation"}
{"concept_id": "C2253677", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of monocyte antigen processing and presentation"}
{"concept_id": "C2253680", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of macrophage antigen processing and presentation"}
{"concept_id": "C2253681", "aliases": [], "types": ["T043"], "canonical_name": "activation of macrophage antigen processing and presentation"}
{"concept_id": "C2253682", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of macrophage antigen processing and presentation"}
{"concept_id": "C2253685", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of non-professional antigen presenting cell antigen processing and presentation"}
{"concept_id": "C2253686", "aliases": [], "types": ["T043"], "canonical_name": "activation of non-professional antigen presenting cell antigen processing and presentation"}
{"concept_id": "C2253687", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of non-professional antigen presenting cell antigen processing and presentation"}
{"concept_id": "C2253690", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of B cell antigen processing and presentation"}
{"concept_id": "C2253691", "aliases": [], "types": ["T043"], "canonical_name": "activation of B cell antigen processing and presentation"}
{"concept_id": "C2253692", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of B cell antigen processing and presentation"}
{"concept_id": "C2253695", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell antigen processing and presentation"}
{"concept_id": "C2253696", "aliases": [], "types": ["T043"], "canonical_name": "activation of T cell antigen processing and presentation"}
{"concept_id": "C2253697", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T cell antigen processing and presentation"}
{"concept_id": "C2253700", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of proteolysis associated with antigen processing and presentation"}
{"concept_id": "C2253701", "aliases": [], "types": ["T039"], "canonical_name": "activation of proteolysis associated with antigen processing and presentation"}
{"concept_id": "C2253702", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of proteolysis associated with antigen processing and presentation"}
{"concept_id": "C2253705", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of granuloma formation"}
{"concept_id": "C2253706", "aliases": [], "types": ["T039"], "canonical_name": "activation of granuloma formation"}
{"concept_id": "C2253707", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of granuloma formation"}
{"concept_id": "C2253710", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of germinal center formation"}
{"concept_id": "C2253711", "aliases": [], "types": ["T040"], "canonical_name": "activation of germinal center formation"}
{"concept_id": "C2253712", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of germinal center formation"}
{"concept_id": "C2253715", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of immunoglobulin production"}
{"concept_id": "C2253716", "aliases": [], "types": ["T043"], "canonical_name": "activation of immunoglobulin production"}
{"concept_id": "C2253717", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of immunoglobulin production"}
{"concept_id": "C2253725", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of tolerance induction"}
{"concept_id": "C2253726", "aliases": [], "types": ["T039"], "canonical_name": "activation of tolerance induction"}
{"concept_id": "C2253727", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of tolerance induction"}
{"concept_id": "C2253730", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of central tolerance induction"}
{"concept_id": "C2253731", "aliases": [], "types": ["T039"], "canonical_name": "activation of central tolerance induction"}
{"concept_id": "C2253732", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of central tolerance induction"}
{"concept_id": "C2253735", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of tolerance induction to self antigen"}
{"concept_id": "C2253736", "aliases": [], "types": ["T039"], "canonical_name": "activation of tolerance induction to self antigen"}
{"concept_id": "C2253737", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of tolerance induction to self antigen"}
{"concept_id": "C2253740", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomeric recombination at telomere"}
{"concept_id": "C2253746", "aliases": ["high affinity phosphate transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity phosphate transmembrane transporter activity", "definition": "Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:jid, PMID:8709965]"}
{"concept_id": "C2253748", "aliases": [], "types": ["T043"], "canonical_name": "activation of receptor mediated endocytosis"}
{"concept_id": "C2253749", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of receptor mediated endocytosis"}
{"concept_id": "C2253750", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of receptor mediated endocytosis"}
{"concept_id": "C2253759", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of isotype switching to IgE isotypes"}
{"concept_id": "C2253762", "aliases": [], "types": ["T045"], "canonical_name": "activation of isotype switching to IgE isotypes"}
{"concept_id": "C2253765", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of isotype switching to IgE isotypes"}
{"concept_id": "C2253770", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of isotype switching to IgA isotypes"}
{"concept_id": "C2253773", "aliases": [], "types": ["T045"], "canonical_name": "activation of isotype switching to IgA isotypes"}
{"concept_id": "C2253776", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of isotype switching to IgA isotypes"}
{"concept_id": "C2253781", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of isotype switching to IgD isotypes"}
{"concept_id": "C2253784", "aliases": [], "types": ["T045"], "canonical_name": "activation of isotype switching to IgD isotypes"}
{"concept_id": "C2253787", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of isotype switching to IgD isotypes"}
{"concept_id": "C2253792", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isotype switching to IgG isotypes"}
{"concept_id": "C2253795", "aliases": [], "types": ["T045"], "canonical_name": "activation of isotype switching to IgG isotypes"}
{"concept_id": "C2253798", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of isotype switching to IgG isotypes"}
{"concept_id": "C2253803", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axial mesodermal cell fate determination"}
{"concept_id": "C2253804", "aliases": [], "types": ["T043"], "canonical_name": "activation of axial mesodermal cell fate determination"}
{"concept_id": "C2253805", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of axial mesodermal cell fate determination"}
{"concept_id": "C2253808", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axial mesodermal cell fate specification"}
{"concept_id": "C2253809", "aliases": [], "types": ["T043"], "canonical_name": "activation of axial mesodermal cell fate specification"}
{"concept_id": "C2253810", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of axial mesodermal cell fate specification"}
{"concept_id": "C2253813", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mesodermal cell fate determination"}
{"concept_id": "C2253814", "aliases": [], "types": ["T043"], "canonical_name": "activation of mesodermal cell fate determination"}
{"concept_id": "C2253815", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mesodermal cell fate determination"}
{"concept_id": "C2253817", "aliases": [], "types": ["T043"], "canonical_name": "activation of mesodermal cell fate specification"}
{"concept_id": "C2253818", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mesodermal cell fate specification"}
{"concept_id": "C2253820", "aliases": [], "types": ["T043"], "canonical_name": "activation of paraxial mesodermal cell fate determination"}
{"concept_id": "C2253821", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of paraxial mesodermal cell fate determination"}
{"concept_id": "C2253824", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of paraxial mesodermal cell fate determination"}
{"concept_id": "C2253825", "aliases": [], "types": ["T043"], "canonical_name": "activation of paraxial mesodermal cell fate specification"}
{"concept_id": "C2253826", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of paraxial mesodermal cell fate specification"}
{"concept_id": "C2253829", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of paraxial mesodermal cell fate specification"}
{"concept_id": "C2253831", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lateral mesodermal cell fate determination"}
{"concept_id": "C2253832", "aliases": [], "types": ["T043"], "canonical_name": "activation of lateral mesodermal cell fate determination"}
{"concept_id": "C2253833", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of lateral mesodermal cell fate determination"}
{"concept_id": "C2253835", "aliases": [], "types": ["T043"], "canonical_name": "activation of lateral mesodermal cell fate specification"}
{"concept_id": "C2253836", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of lateral mesodermal cell fate specification"}
{"concept_id": "C2253839", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lateral mesodermal cell fate specification"}
{"concept_id": "C2253840", "aliases": [], "types": ["T040"], "canonical_name": "activation of retinoic acid receptor signaling pathway"}
{"concept_id": "C2253841", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of retinoic acid receptor signaling pathway"}
{"concept_id": "C2253844", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of retinoic acid receptor signaling pathway"}
{"concept_id": "C2253846", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intermediate mesodermal cell fate determination"}
{"concept_id": "C2253847", "aliases": [], "types": ["T043"], "canonical_name": "activation of intermediate mesodermal cell fate determination"}
{"concept_id": "C2253848", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of intermediate mesodermal cell fate determination"}
{"concept_id": "C2253850", "aliases": [], "types": ["T043"], "canonical_name": "activation of intermediate mesodermal cell fate specification"}
{"concept_id": "C2253851", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of intermediate mesodermal cell fate specification"}
{"concept_id": "C2253854", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intermediate mesodermal cell fate specification"}
{"concept_id": "C2253855", "aliases": [], "types": ["T026"], "canonical_name": "perinuclear region of cytoplasm", "definition": "Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]"}
{"concept_id": "C2253856", "aliases": [], "types": ["T044"], "canonical_name": "L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]"}
{"concept_id": "C2253861", "aliases": [], "types": ["T039"], "canonical_name": "activation of biological process"}
{"concept_id": "C2253862", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of biological process"}
{"concept_id": "C2253865", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of biological process"}
{"concept_id": "C2253866", "aliases": [], "types": ["T040"], "canonical_name": "activation of behavior"}
{"concept_id": "C2253867", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of behavior"}
{"concept_id": "C2253870", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of behavior"}
{"concept_id": "C2253871", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular process"}
{"concept_id": "C2253872", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cellular process"}
{"concept_id": "C2253875", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular process"}
{"concept_id": "C2253876", "aliases": ["activation of viral life cycle"], "types": ["T039"], "canonical_name": "activation of viral life cycle"}
{"concept_id": "C2253877", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of viral life cycle"}
{"concept_id": "C2253878", "aliases": ["inhibition of viral life cycle"], "types": ["T039"], "canonical_name": "inhibition of viral life cycle"}
{"concept_id": "C2253882", "aliases": [], "types": ["T043"], "canonical_name": "activation of pinocytosis"}
{"concept_id": "C2253883", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of pinocytosis"}
{"concept_id": "C2253886", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pinocytosis"}
{"concept_id": "C2253888", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloenzyme activity"}
{"concept_id": "C2253889", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloenzyme activity"}
{"concept_id": "C2253890", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of metalloenzyme activity"}
{"concept_id": "C2253892", "aliases": [], "types": ["T039"], "canonical_name": "activation of short-day photoperiodism, flowering"}
{"concept_id": "C2253893", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of short-day photoperiodism, flowering"}
{"concept_id": "C2253896", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of short-day photoperiodism, flowering"}
{"concept_id": "C2253897", "aliases": [], "types": ["T039"], "canonical_name": "activation of long-day photoperiodism, flowering"}
{"concept_id": "C2253898", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of long-day photoperiodism, flowering"}
{"concept_id": "C2253901", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of long-day photoperiodism, flowering"}
{"concept_id": "C2253903", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of post-embryonic development"}
{"concept_id": "C2253904", "aliases": [], "types": ["T039"], "canonical_name": "activation of post-embryonic development"}
{"concept_id": "C2253905", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of post-embryonic development"}
{"concept_id": "C2253907", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to stimulus"}
{"concept_id": "C2253908", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of response to stimulus"}
{"concept_id": "C2253911", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of response to stimulus"}
{"concept_id": "C2253913", "aliases": ["inhibition of skeletal muscle growth", "downregulation of skeletal muscle growth", "down-regulation of skeletal muscle growth", "down regulation of skeletal muscle growth"], "types": ["T040"], "canonical_name": "negative regulation of skeletal muscle tissue growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth. [GOC:lm, PMID:15726494, PMID:15907921]"}
{"concept_id": "C2253914", "aliases": ["activation of skeletal muscle growth", "up regulation of skeletal muscle growth", "upregulation of skeletal muscle growth", "up-regulation of skeletal muscle growth"], "types": ["T040"], "canonical_name": "positive regulation of skeletal muscle tissue growth", "definition": "Any process that activates, maintains or increases the rate of skeletal muscle growth. [GOC:lm, PMID:15726494, PMID:15907921]"}
{"concept_id": "C2253915", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of skeletal muscle growth"}
{"concept_id": "C2253918", "aliases": ["down regulation of muscle development", "downregulation of muscle development", "inhibition of muscle development", "down-regulation of muscle development"], "types": ["T040"], "canonical_name": "negative regulation of muscle organ development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. [GOC:go_curators]"}
{"concept_id": "C2253919", "aliases": ["up regulation of muscle development", "upregulation of muscle development", "stimulation of muscle development", "up-regulation of muscle development", "activation of muscle development"], "types": ["T040"], "canonical_name": "positive regulation of muscle organ development", "definition": "Any process that activates, maintains or increases the rate of muscle development. [GOC:go_curators]"}
{"concept_id": "C2253922", "aliases": [], "types": ["T040"], "canonical_name": "activation of developmental growth"}
{"concept_id": "C2253923", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of developmental growth"}
{"concept_id": "C2253926", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of developmental growth"}
{"concept_id": "C2253928", "aliases": ["down regulation of skeletal muscle development", "inhibition of skeletal muscle development", "downregulation of skeletal muscle development", "down-regulation of skeletal muscle development"], "types": ["T040"], "canonical_name": "negative regulation of skeletal muscle tissue development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. [GOC:go_curators]"}
{"concept_id": "C2253929", "aliases": ["stimulation of skeletal muscle development", "activation of skeletal muscle development", "upregulation of skeletal muscle development", "up-regulation of skeletal muscle development", "up regulation of skeletal muscle development"], "types": ["T040"], "canonical_name": "positive regulation of skeletal muscle tissue development", "definition": "Any process that activates, maintains or increases the rate of skeletal muscle tissue development. [GOC:go_curators]"}
{"concept_id": "C2253935", "aliases": [], "types": ["T043"], "canonical_name": "activation of smooth muscle cell proliferation"}
{"concept_id": "C2253936", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of smooth muscle cell proliferation"}
{"concept_id": "C2253939", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of smooth muscle cell proliferation"}
{"concept_id": "C2253941", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of collateral sprouting"}
{"concept_id": "C2253942", "aliases": [], "types": ["T043"], "canonical_name": "activation of collateral sprouting"}
{"concept_id": "C2253943", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of collateral sprouting"}
{"concept_id": "C2253945", "aliases": [], "types": ["T042"], "canonical_name": "activation of axon regeneration"}
{"concept_id": "C2253946", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of axon regeneration"}
{"concept_id": "C2253949", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of axon regeneration"}
{"concept_id": "C2253950", "aliases": [], "types": ["T043"], "canonical_name": "activation of collateral sprouting of intact axon in response to injury"}
{"concept_id": "C2253951", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of collateral sprouting of intact axon in response to injury"}
{"concept_id": "C2253954", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of collateral sprouting of intact axon in response to injury"}
{"concept_id": "C2253955", "aliases": [], "types": ["T042"], "canonical_name": "activation of sprouting of injured axon"}
{"concept_id": "C2253956", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of sprouting of injured axon"}
{"concept_id": "C2253959", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of sprouting of injured axon"}
{"concept_id": "C2253960", "aliases": [], "types": ["T039"], "canonical_name": "activation of axon extension involved in regeneration"}
{"concept_id": "C2253961", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of axon extension involved in regeneration"}
{"concept_id": "C2253964", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of axon extension involved in regeneration"}
{"concept_id": "C2253965", "aliases": [], "types": ["T043"], "canonical_name": "activation of collateral sprouting of injured axon"}
{"concept_id": "C2253966", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of collateral sprouting of injured axon"}
{"concept_id": "C2253969", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of collateral sprouting of injured axon"}
{"concept_id": "C2253970", "aliases": [], "types": ["T043"], "canonical_name": "activation of collateral sprouting in the absence of injury"}
{"concept_id": "C2253971", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of collateral sprouting in the absence of injury"}
{"concept_id": "C2253974", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of collateral sprouting in the absence of injury"}
{"concept_id": "C2253975", "aliases": [], "types": ["T043"], "canonical_name": "activation of astrocyte differentiation"}
{"concept_id": "C2253976", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of astrocyte differentiation"}
{"concept_id": "C2253979", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of astrocyte differentiation"}
{"concept_id": "C2253980", "aliases": [], "types": ["T043"], "canonical_name": "activation of oligodendrocyte differentiation"}
{"concept_id": "C2253981", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of oligodendrocyte differentiation"}
{"concept_id": "C2253984", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of oligodendrocyte differentiation"}
{"concept_id": "C2253988", "aliases": [], "types": ["T040"], "canonical_name": "activation of skeletal muscle fiber development"}
{"concept_id": "C2253990", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of skeletal muscle fiber development"}
{"concept_id": "C2253993", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of skeletal muscle fiber development"}
{"concept_id": "C2253998", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of leucophore differentiation"}
{"concept_id": "C2253999", "aliases": [], "types": ["T043"], "canonical_name": "activation of leucophore differentiation"}
{"concept_id": "C2254000", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of leucophore differentiation"}
{"concept_id": "C2254003", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of erythrophore differentiation"}
{"concept_id": "C2254004", "aliases": [], "types": ["T043"], "canonical_name": "activation of erythrophore differentiation"}
{"concept_id": "C2254005", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of erythrophore differentiation"}
{"concept_id": "C2254008", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cyanophore differentiation"}
{"concept_id": "C2254009", "aliases": [], "types": ["T043"], "canonical_name": "activation of cyanophore differentiation"}
{"concept_id": "C2254010", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cyanophore differentiation"}
{"concept_id": "C2254012", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc-derived male genitalia morphogenesis", "definition": "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc. [GOC:ai, GOC:sensu]"}
{"concept_id": "C2254013", "aliases": [], "types": ["T042"], "canonical_name": "imaginal disc-derived genitalia morphogenesis", "definition": "The process in which the anatomical structures of genitalia are generated and organized from the genital imaginal disc. [GOC:ai, GOC:sensu]"}
{"concept_id": "C2254015", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of hair follicle maturation"}
{"concept_id": "C2254016", "aliases": [], "types": ["T039"], "canonical_name": "activation of hair follicle maturation"}
{"concept_id": "C2254017", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of hair follicle maturation"}
{"concept_id": "C2254019", "aliases": [], "types": ["T042"], "canonical_name": "specification of plant organ number", "definition": "The regionalization process that modulates the quantity of a particular type of plant organ. [GOC:dph, GOC:isa_complete, GOC:tb]"}
{"concept_id": "C2254020", "aliases": [], "types": ["T043"], "canonical_name": "activation of axon extension involved in axon guidance"}
{"concept_id": "C2254021", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of axon extension involved in axon guidance"}
{"concept_id": "C2254024", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axon extension involved in axon guidance"}
{"concept_id": "C2254026", "aliases": [], "types": ["T042"], "canonical_name": "chemical homeostasis within retina", "definition": "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the retina. [GOC:isa_complete]"}
{"concept_id": "C2254027", "aliases": [], "types": ["T040"], "canonical_name": "homeostasis of number of retina cells", "definition": "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina. [GOC:dph, GOC:isa_complete, GOC:tb]"}
{"concept_id": "C2254039", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]"}
{"concept_id": "C2254157", "aliases": ["L-leucine aminotransferase activity"], "types": ["T044"], "canonical_name": "L-leucine transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid. [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN]"}
{"concept_id": "C2254158", "aliases": ["leucine-alpha-ketoglutarate transaminase activity", "leucine 2-oxoglutarate transaminase activity"], "types": ["T044"], "canonical_name": "L-leucine:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate. [EC:2.6.1.6, MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN]"}
{"concept_id": "C2254214", "aliases": [], "types": ["T044"], "canonical_name": "lysolecithin migratase activity"}
{"concept_id": "C2254218", "aliases": [], "types": ["T044"], "canonical_name": "decapase activity"}
{"concept_id": "C2254221", "aliases": [], "types": ["T044"], "canonical_name": "malate thiokinase activity"}
{"concept_id": "C2254253", "aliases": ["polyol dehydrogenase activity"], "types": ["T044"], "canonical_name": "polyol dehydrogenase activity"}
{"concept_id": "C2254321", "aliases": [], "types": ["T044"], "canonical_name": "menthol transacetylase activity"}
{"concept_id": "C2254340", "aliases": ["protein phosphatase-2A activity", "protein phosphatase 2A"], "types": ["T044"], "canonical_name": "protein phosphatase-2A"}
{"concept_id": "C2254370", "aliases": [], "types": ["T044"], "canonical_name": "nalpha-benzyloxycarbonyl amino acid urethane hydrolase I"}
{"concept_id": "C2254382", "aliases": [], "types": ["T044"], "canonical_name": "beta-citryl-L-glutamate-hydrolyzing enzyme"}
{"concept_id": "C2254427", "aliases": ["nitroalkane:oxygen oxidoreductase activity", "NAO activity", "nitroalkane reductase activity"], "types": ["T044"], "canonical_name": "nitroalkane oxidase activity", "definition": "Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2. [EC:1.7.3.1]"}
{"concept_id": "C2254434", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)"}
{"concept_id": "C2254435", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]"}
{"concept_id": "C2254506", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglutaminase I activity"}
{"concept_id": "C2254581", "aliases": [], "types": ["T044"], "canonical_name": "PR-enzyme"}
{"concept_id": "C2254582", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase C"}
{"concept_id": "C2254587", "aliases": ["stilbene synthase activity"], "types": ["T044"], "canonical_name": "stilbene synthase activity"}
{"concept_id": "C2254602", "aliases": [], "types": ["T044"], "canonical_name": "octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]"}
{"concept_id": "C2254641", "aliases": ["steroid 5-alpha-reductase activity"], "types": ["T044"], "canonical_name": "steroid 5-alpha-reductase activity"}
{"concept_id": "C2254680", "aliases": [], "types": ["T044"], "canonical_name": "PGE2-9-OR"}
{"concept_id": "C2254713", "aliases": [], "types": ["T044"], "canonical_name": "L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]"}
{"concept_id": "C2254716", "aliases": ["pyridoxin dehydrogenase activity", "pyridoxine:NADP 4-oxidoreductase activity", "pyridoxal reductase activity", "pyridoxol dehydrogenase activity", "PL reductase activity", "pyridoxine dehydrogenase activity"], "types": ["T044"], "canonical_name": "pyridoxine:NADP 4-dehydrogenase activity", "definition": "Catalysis of the reaction: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal. [EC:1.1.1.65, RHEA:16129]"}
{"concept_id": "C2254732", "aliases": ["pyruvate-phosphate dikinase (phosphorylating)", "orthophosphate dikinase pyruvate", "pyruvic-phosphate dikinase activity", "pyruvate-inorganic phosphate dikinase activity", "pyruvate-phosphate dikinase activity", "pyruvate-phosphate ligase activity", "pyruvate, Pi dikinase activity", "pyruvate, phosphate dikinase activity", "ATP:pyruvate, phosphate phosphotransferase activity", "pyruvic-phosphate ligase activity", "PPDK", "pyruvate,phosphate dikinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H(+) + phosphoenolpyruvate. [EC:2.7.9.1, RHEA:10756]", "canonical_name": "pyruvate,orthophosphate dikinase activity"}
{"concept_id": "C2254748", "aliases": [], "types": ["T044"], "canonical_name": "aequorin activity"}
{"concept_id": "C2254755", "aliases": [], "types": ["T044"], "canonical_name": "luciferin sulfotransferase activity"}
{"concept_id": "C2254768", "aliases": [], "types": ["T044"], "canonical_name": "cone opsin kinase activity"}
{"concept_id": "C2254769", "aliases": [], "types": ["T044"], "canonical_name": "G-protein-coupled receptor kinase 1 activity"}
{"concept_id": "C2254770", "aliases": [], "types": ["T044"], "canonical_name": "GPCR kinase 1 activity"}
{"concept_id": "C2254775", "aliases": [], "types": ["T044"], "canonical_name": "ribitol dehydrogenase A (wild type)"}
{"concept_id": "C2254776", "aliases": [], "types": ["T044"], "canonical_name": "ribitol dehydrogenase B (mutant enzyme with different properties)"}
{"concept_id": "C2254777", "aliases": [], "types": ["T044"], "canonical_name": "ribitol dehydrogenase D (mutant enzyme with different properties)"}
{"concept_id": "C2254798", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside ribohydrolase activity"}
{"concept_id": "C2254814", "aliases": [], "types": ["T044"], "canonical_name": "rubber transferase activity"}
{"concept_id": "C2254877", "aliases": [], "types": ["T044"], "canonical_name": "steroid alcohol sulfotransferase"}
{"concept_id": "C2254886", "aliases": ["APH(6) activity"], "types": ["T044"], "canonical_name": "aminoglycoside 6-kinase activity", "definition": "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 6-phosphate. [EC:2.7.1.72, RHEA:22268]"}
{"concept_id": "C2254887", "aliases": [], "types": ["T044"], "canonical_name": "ATP:streptomycin 6-phosphotransferase activity"}
{"concept_id": "C2254889", "aliases": [], "types": ["T044"], "canonical_name": "streptidine kinase (phosphorylating)"}
{"concept_id": "C2254890", "aliases": [], "types": ["T044"], "canonical_name": "streptidine kinase activity"}
{"concept_id": "C2254891", "aliases": [], "types": ["T044"], "canonical_name": "streptomycin 6-kinase (phosphorylating)"}
{"concept_id": "C2254892", "aliases": [], "types": ["T044"], "canonical_name": "streptomycin 6-O-phosphotransferase activity"}
{"concept_id": "C2254893", "aliases": [], "types": ["T044"], "canonical_name": "streptomycin 6-phosphotransferase activity"}
{"concept_id": "C2254918", "aliases": ["sucrose-6F-phosphate phosphohydrolase activity", "sucrose-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "sucrose-phosphate phosphatase activity", "definition": "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate. [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN]"}
{"concept_id": "C2254925", "aliases": [], "types": ["T044"], "canonical_name": "xylitol-5-phosphatase activity"}
{"concept_id": "C2254938", "aliases": [], "types": ["T044"], "canonical_name": "tannase S"}
{"concept_id": "C2254944", "aliases": [], "types": ["T044"], "canonical_name": "ATP:tau-protein O-phosphotransferase activity"}
{"concept_id": "C2254945", "aliases": [], "types": ["T044"], "canonical_name": "brain protein kinase PK40erk activity"}
{"concept_id": "C2254946", "aliases": [], "types": ["T044"], "canonical_name": "cdk5/p20"}
{"concept_id": "C2254947", "aliases": [], "types": ["T044"], "canonical_name": "CDK5/p23"}
{"concept_id": "C2254950", "aliases": [], "types": ["T044"], "canonical_name": "tau-protein kinase I activity"}
{"concept_id": "C2254951", "aliases": [], "types": ["T044"], "canonical_name": "tau-protein kinase II activity"}
{"concept_id": "C2254952", "aliases": [], "types": ["T044"], "canonical_name": "tau-tubulin kinase activity"}
{"concept_id": "C2254974", "aliases": ["thiamin pyrophosphate kinase activity", "thiamin diphosphate kinase activity", "thiamine diphosphate kinase activity", "thiamin diphosphate phosphotransferase activity", "thiamin-diphosphate kinase activity", "ATP:thiamine-diphosphate phosphotransferase activity", "TDP kinase activity", "ATP:thiamin-diphosphate phosphotransferase activity", "protein bound thiamin diphosphate:ATP phosphoryltransferase activity"], "types": ["T044"], "canonical_name": "thiamine-diphosphate kinase activity", "definition": "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate. [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN]"}
{"concept_id": "C2254977", "aliases": ["thiamin pyridinylase activity", "thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity", "pyrimidine transferase activity", "thiamin pyridinolase activity", "thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity", "thiamin hydrolase activity", "thiamine pyridinolase activity", "thiamine hydrolase activity"], "types": ["T044"], "canonical_name": "thiamine pyridinylase activity", "definition": "Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine. [EC:2.5.1.2, RHEA:17697]"}
{"concept_id": "C2254981", "aliases": [], "types": ["T044"], "canonical_name": "thiaminase I activity"}
{"concept_id": "C2254984", "aliases": [], "types": ["T044"], "canonical_name": "thiaminase II activity"}
{"concept_id": "C2254997", "aliases": [], "types": ["T044"], "canonical_name": "thiosulfate-oxidizing enzyme"}
{"concept_id": "C2255044", "aliases": ["malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)"], "types": ["T044"], "canonical_name": "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)"}
{"concept_id": "C2255075", "aliases": [], "types": ["T044"], "canonical_name": "tropinone reductase II activity"}
{"concept_id": "C2255087", "aliases": [], "types": ["T044"], "canonical_name": "5-hydroxytryptophan-ketoglutaric transaminase activity"}
{"concept_id": "C2255088", "aliases": [], "types": ["T044"], "canonical_name": "hydroxytryptophan aminotransferase activity"}
{"concept_id": "C2255089", "aliases": ["L-tryptophan aminotransferase activity"], "types": ["T044"], "canonical_name": "L-tryptophan aminotransferase activity", "definition": "Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid. [GOC:mah]"}
{"concept_id": "C2255090", "aliases": [], "types": ["T044"], "canonical_name": "L-tryptophan transaminase activity"}
{"concept_id": "C2255091", "aliases": ["tryptophan aminotransferase activity", "tryptophan transaminase activity"], "types": ["T044"], "canonical_name": "L-tryptophan:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate. [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN]"}
{"concept_id": "C2255102", "aliases": [], "types": ["T044"], "canonical_name": "L-tryptophan aminopeptidase"}
{"concept_id": "C2255104", "aliases": [], "types": ["T044"], "canonical_name": "tryptophan aminopeptidase"}
{"concept_id": "C2255120", "aliases": [], "types": ["T044"], "canonical_name": "CYP79A1 activity"}
{"concept_id": "C2255144", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphospho-D-galacturonic acid"}
{"concept_id": "C2255175", "aliases": [], "types": ["T044"], "canonical_name": "ureidoglycolase activity"}
{"concept_id": "C2255176", "aliases": [], "types": ["T044"], "canonical_name": "ureidoglycolatase activity"}
{"concept_id": "C2255203", "aliases": [], "types": ["T044"], "canonical_name": "jojoba wax esterase"}
{"concept_id": "C2255223", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA carboxylase bound kinase activity"}
{"concept_id": "C2255226", "aliases": ["acetyl-CoA carboxylase kinase-2 activity"], "types": ["T044"], "canonical_name": "acetyl-CoA carboxylase kinase 2 activity"}
{"concept_id": "C2255227", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA carboxylase kinase-3 (AMP-activated) activity"}
{"concept_id": "C2255230", "aliases": [], "types": ["T044"], "canonical_name": "I-peptide kinase activity"}
{"concept_id": "C2255236", "aliases": [], "types": ["T044"], "canonical_name": "phosphatase type 2oC"}
{"concept_id": "C2255272", "aliases": [], "types": ["T044"], "canonical_name": "cd-cytochrome nitrite reductase activity"}
{"concept_id": "C2255273", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity"}
{"concept_id": "C2255275", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome cd activity"}
{"concept_id": "C2255276", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome cd1 activity"}
{"concept_id": "C2255277", "aliases": [], "types": ["T044"], "canonical_name": "methyl viologen-nitrite reductase activity"}
{"concept_id": "C2255279", "aliases": [], "types": ["T044"], "canonical_name": "Pseudomonas cytochrome oxidase activity"}
{"concept_id": "C2255281", "aliases": ["thiamine dehydrogenase activity", "thiamin:oxygen 5-oxidoreductase activity", "thiamin dehydrogenase activity", "thiamin oxidase activity", "thiamine:oxygen 5-oxidoreductase activity"], "types": ["T044"], "canonical_name": "thiamine oxidase activity", "definition": "Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2. [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN]"}
{"concept_id": "C2255292", "aliases": [], "types": ["T045"], "canonical_name": "activation of viral transcription"}
{"concept_id": "C2255293", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of viral transcription"}
{"concept_id": "C2255297", "aliases": [], "types": ["T044"], "canonical_name": "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]"}
{"concept_id": "C2255333", "aliases": ["azoreductase activity"], "types": ["T044"], "canonical_name": "azo reductase activity"}
{"concept_id": "C2255334", "aliases": [], "types": ["T044"], "canonical_name": "azo-dye reductase activity"}
{"concept_id": "C2255337", "aliases": [], "types": ["T044"], "canonical_name": "methyl red azoreductase activity"}
{"concept_id": "C2255341", "aliases": [], "types": ["T044"], "canonical_name": "NADPH-dependent azoreductase activity"}
{"concept_id": "C2255345", "aliases": ["New coccine (NC)-reductase activity", "new coccine (NC)-reductase"], "types": ["T044"], "canonical_name": "NC-reductase activity"}
{"concept_id": "C2255349", "aliases": [], "types": ["T044"], "canonical_name": "orange I azoreductase activity"}
{"concept_id": "C2255350", "aliases": [], "types": ["T044"], "canonical_name": "orange II azoreductase activity"}
{"concept_id": "C2255367", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]"}
{"concept_id": "C2255369", "aliases": [], "types": ["T044"], "canonical_name": "citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]"}
{"concept_id": "C2255370", "aliases": [], "types": ["T044"], "canonical_name": "CoA-disulfide reductase (NAD(P)H) activity"}
{"concept_id": "C2255372", "aliases": [], "types": ["T044"], "canonical_name": "CoA-disulfide reductase [NAD(P)H]"}
{"concept_id": "C2255408", "aliases": [], "types": ["T044"], "canonical_name": "amino alcohol O-phosphate phospholyase activity"}
{"concept_id": "C2255428", "aliases": [], "types": ["T044"], "canonical_name": "assimilatory NAD(P)H-nitrate reductase activity"}
{"concept_id": "C2255433", "aliases": [], "types": ["T044"], "canonical_name": "nitrate reductase [NAD(P)H2]"}
{"concept_id": "C2255469", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]"}
{"concept_id": "C2255516", "aliases": [], "types": ["T044"], "canonical_name": "MurG transferase activity"}
{"concept_id": "C2255521", "aliases": [], "types": ["T044"], "canonical_name": "globotriaosylceramide/CD77 synthase activity"}
{"concept_id": "C2255522", "aliases": [], "types": ["T044"], "canonical_name": "histo-blood group P(k) UDP-galactose activity"}
{"concept_id": "C2255523", "aliases": [], "types": ["T044"], "canonical_name": "histo-blood group Pk UDP-galactose"}
{"concept_id": "C2255529", "aliases": [], "types": ["T044"], "canonical_name": "CMK activity"}
{"concept_id": "C2255536", "aliases": [], "types": ["T044"], "canonical_name": "MCT activity"}
{"concept_id": "C2255545", "aliases": ["poly((R)-hydroxyalkanoic acid) depolymerase activity"], "types": ["T044"], "canonical_name": "poly((R)-hydroxyalkanoic acid) depolymerase activity"}
{"concept_id": "C2255548", "aliases": ["poly(HA) depolymerase activity"], "types": ["T044"], "canonical_name": "poly(HA) depolymerase activity"}
{"concept_id": "C2255551", "aliases": ["poly[(R)-hydroxyalkanoic acid] depolymerase"], "types": ["T044"], "canonical_name": "poly[(R)-hydroxyalkanoic acid] depolymerase"}
{"concept_id": "C2255552", "aliases": [], "types": ["T044"], "canonical_name": "PHA depolymerase activity"}
{"concept_id": "C2255565", "aliases": [], "types": ["T044"], "canonical_name": "ComB phosphatase activity"}
{"concept_id": "C2255579", "aliases": [], "types": ["T044"], "canonical_name": "imidase activity"}
{"concept_id": "C2255595", "aliases": ["pinene synthase activity", "(-)-(1S,5S)-pinene synthase activity", "beta-geraniolene synthase activity", "geranyldiphosphate diphosphate lyase (pinene forming)"], "types": ["T044"], "definition": "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate. [EC:4.2.3.14, MetaCyc:4.2.3.14-RXN]", "canonical_name": "geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)"}
{"concept_id": "C2255596", "aliases": [], "types": ["T044"], "canonical_name": "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]"}
{"concept_id": "C2255598", "aliases": [], "types": ["T044"], "canonical_name": "geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]"}
{"concept_id": "C2255621", "aliases": [], "types": ["T044"], "canonical_name": "nondiscriminating aspartyl-tRNA synthetase activity"}
{"concept_id": "C2255623", "aliases": [], "types": ["T044"], "canonical_name": "nondiscriminating glutamyl-tRNA synthetase activity"}
{"concept_id": "C2255649", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglutaminase II activity"}
{"concept_id": "C2255650", "aliases": [], "types": ["T044"], "canonical_name": "peptidylglutaminase II"}
{"concept_id": "C2255666", "aliases": [], "types": ["T044"], "canonical_name": "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase"}
{"concept_id": "C2255676", "aliases": [], "types": ["T044"], "canonical_name": "YqhE reductase"}
{"concept_id": "C2255677", "aliases": [], "types": ["T044"], "canonical_name": "D-arabinitol oxidase activity"}
{"concept_id": "C2255683", "aliases": [], "types": ["T044"], "canonical_name": "NADP-linked hydrogenase activity"}
{"concept_id": "C2255684", "aliases": [], "types": ["T044"], "canonical_name": "NADP-reducing hydrogenase activity"}
{"concept_id": "C2255688", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxyphenylpyruvate dioxygenase II activity"}
{"concept_id": "C2255693", "aliases": ["anthocyanidin synthase activity"], "types": ["T044"], "canonical_name": "anthocyanidin synthase activity", "definition": "Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C2255705", "aliases": [], "types": ["T044"], "canonical_name": "CYP71E1 activity"}
{"concept_id": "C2255718", "aliases": [], "types": ["T044"], "canonical_name": "penicillin N expandase activity"}
{"concept_id": "C2255720", "aliases": [], "types": ["T044"], "canonical_name": "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating]"}
{"concept_id": "C2255721", "aliases": [], "types": ["T044"], "canonical_name": "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(E) desaturating]"}
{"concept_id": "C2255732", "aliases": [], "types": ["T044"], "canonical_name": "desulfoferrodoxin activity"}
{"concept_id": "C2255733", "aliases": [], "types": ["T044"], "canonical_name": "neelaredoxin activity"}
{"concept_id": "C2255738", "aliases": ["4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity", "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP(+) oxidoreductase activity", "alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity", "2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity", "definition": "Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH. [RHEA:29587]"}
{"concept_id": "C2255751", "aliases": [], "types": ["T044"], "canonical_name": "lanosterol Delta(24)-reductase activity"}
{"concept_id": "C2255791", "aliases": [], "types": ["T044"], "canonical_name": "peroxisomal 3-oxoacyl coenzyme A thiolase"}
{"concept_id": "C2255792", "aliases": [], "types": ["T044"], "canonical_name": "peroxisome sterol carrier protein thiolase"}
{"concept_id": "C2255793", "aliases": [], "types": ["T044"], "canonical_name": "sterol carrier protein"}
{"concept_id": "C2255808", "aliases": ["acetyl-CoA:taxan-10beta-ol O-acetyltransferase"], "types": ["T044"], "canonical_name": "acetyl-CoA:taxan-10beta-ol O-acetyltransferase"}
{"concept_id": "C2255822", "aliases": [], "types": ["T040"], "canonical_name": "activation of homocysteine metabolic process"}
{"concept_id": "C2255823", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of homocysteine metabolic process"}
{"concept_id": "C2255826", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of homocysteine metabolic process"}
{"concept_id": "C2255827", "aliases": [], "types": ["T043"], "canonical_name": "activation of lymphocyte proliferation"}
{"concept_id": "C2255828", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of lymphocyte proliferation"}
{"concept_id": "C2255831", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lymphocyte proliferation"}
{"concept_id": "C2255833", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of urothelial cell proliferation"}
{"concept_id": "C2255834", "aliases": [], "types": ["T043"], "canonical_name": "activation of urothelial cell proliferation"}
{"concept_id": "C2255835", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of urothelial cell proliferation"}
{"concept_id": "C2255837", "aliases": [], "types": ["T043"], "canonical_name": "activation of epithelial cell proliferation"}
{"concept_id": "C2255838", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of epithelial cell proliferation"}
{"concept_id": "C2255841", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of epithelial cell proliferation"}
{"concept_id": "C2255842", "aliases": [], "types": ["T045"], "canonical_name": "activation of mRNA processing"}
{"concept_id": "C2255843", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of mRNA processing"}
{"concept_id": "C2255846", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mRNA processing"}
{"concept_id": "C2255847", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antiviral response"}
{"concept_id": "C2255848", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antiviral response by host"}
{"concept_id": "C2255852", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein secretion"}
{"concept_id": "C2255861", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein secretion"}
{"concept_id": "C2255862", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein secretion"}
{"concept_id": "C2255887", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of inflammatory response"}
{"concept_id": "C2255888", "aliases": [], "types": ["T040"], "canonical_name": "activation of inflammatory response"}
{"concept_id": "C2255889", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of inflammatory response"}
{"concept_id": "C2255891", "aliases": [], "types": ["T040"], "canonical_name": "activation of peptidyl-tyrosine phosphorylation"}
{"concept_id": "C2255892", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of peptidyl-tyrosine phosphorylation"}
{"concept_id": "C2255895", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of peptidyl-tyrosine phosphorylation"}
{"concept_id": "C2255896", "aliases": [], "types": ["T040"], "canonical_name": "activation of lipoprotein metabolic process"}
{"concept_id": "C2255897", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of lipoprotein metabolic process"}
{"concept_id": "C2255900", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lipoprotein metabolic process"}
{"concept_id": "C2255912", "aliases": [], "types": ["T043"], "canonical_name": "activation of phagocytosis"}
{"concept_id": "C2255913", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of phagocytosis"}
{"concept_id": "C2255916", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of neurogenesis"}
{"concept_id": "C2255917", "aliases": [], "types": ["T042"], "canonical_name": "activation of neurogenesis"}
{"concept_id": "C2255918", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of neurogenesis"}
{"concept_id": "C2255921", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of axonogenesis"}
{"concept_id": "C2255922", "aliases": [], "types": ["T042"], "canonical_name": "activation of axonogenesis"}
{"concept_id": "C2255923", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of axonogenesis"}
{"concept_id": "C2255926", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dendrite morphogenesis"}
{"concept_id": "C2255927", "aliases": [], "types": ["T043"], "canonical_name": "activation of dendrite morphogenesis"}
{"concept_id": "C2255928", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of dendrite morphogenesis"}
{"concept_id": "C2255931", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of immune response"}
{"concept_id": "C2255932", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of immune response"}
{"concept_id": "C2255937", "aliases": [], "types": ["T040"], "canonical_name": "electrolyte homeostasis"}
{"concept_id": "C2255939", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of synaptic transmission"}
{"concept_id": "C2255940", "aliases": [], "types": ["T042"], "canonical_name": "activation of synaptic transmission"}
{"concept_id": "C2255941", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of synaptic transmission"}
{"concept_id": "C2255943", "aliases": ["succinic dehydrogenase activity"], "types": ["T044"], "canonical_name": "succinic dehydrogenase activity"}
{"concept_id": "C2255950", "aliases": [], "types": ["T026"], "canonical_name": "incipient cellular bud site", "definition": "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence. [GOC:clt]"}
{"concept_id": "C2255954", "aliases": [], "types": ["T045"], "canonical_name": "rRNA editing"}
{"concept_id": "C2255957", "aliases": ["NADH pyrophosphohydrolase activity", "NADH diphosphatase activity"], "types": ["T044"], "canonical_name": "NADH pyrophosphatase activity", "definition": "Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+. [PMID:12399474, PMID:20181750, RHEA:48868]"}
{"concept_id": "C2255958", "aliases": [], "types": ["T044"], "canonical_name": "NADP pyrophosphatase activity"}
{"concept_id": "C2255967", "aliases": [], "types": ["T045"], "canonical_name": "yeast 2'-phosphotransferase activity"}
{"concept_id": "C2255968", "aliases": [], "types": ["T044"], "canonical_name": "glycopeptidase activity"}
{"concept_id": "C2255969", "aliases": [], "types": ["T044"], "canonical_name": "glycopeptide N-glycosidase activity"}
{"concept_id": "C2255970", "aliases": [], "types": ["T044"], "canonical_name": "jack-bean glycopeptidase"}
{"concept_id": "C2255971", "aliases": [], "types": ["T044"], "canonical_name": "N-glycanase activity"}
{"concept_id": "C2255973", "aliases": [], "types": ["T044"], "canonical_name": "N-oligosaccharide glycopeptidase activity"}
{"concept_id": "C2255974", "aliases": [], "types": ["T044"], "canonical_name": "PNGase A"}
{"concept_id": "C2255980", "aliases": [], "types": ["T044"], "canonical_name": "oxaloacetate secondary active transmembrane transporter activity", "definition": "Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]"}
{"concept_id": "C2255983", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of tolerance induction dependent upon immune response"}
{"concept_id": "C2255984", "aliases": [], "types": ["T039"], "canonical_name": "activation of tolerance induction dependent upon immune response"}
{"concept_id": "C2255985", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of tolerance induction dependent upon immune response"}
{"concept_id": "C2255988", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of tolerance induction to nonself antigen"}
{"concept_id": "C2255989", "aliases": [], "types": ["T039"], "canonical_name": "activation of tolerance induction to nonself antigen"}
{"concept_id": "C2255990", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of tolerance induction to nonself antigen"}
{"concept_id": "C2255993", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of peripheral tolerance induction"}
{"concept_id": "C2255994", "aliases": [], "types": ["T039"], "canonical_name": "activation of peripheral tolerance induction"}
{"concept_id": "C2255995", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of peripheral tolerance induction"}
{"concept_id": "C2255998", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of B cell tolerance induction"}
{"concept_id": "C2255999", "aliases": [], "types": ["T039"], "canonical_name": "activation of B cell tolerance induction"}
{"concept_id": "C2256000", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of B cell tolerance induction"}
{"concept_id": "C2256003", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of T cell tolerance induction"}
{"concept_id": "C2256004", "aliases": [], "types": ["T039"], "canonical_name": "activation of T cell tolerance induction"}
{"concept_id": "C2256005", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of T cell tolerance induction"}
{"concept_id": "C2256008", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell anergy"}
{"concept_id": "C2256009", "aliases": [], "types": ["T043"], "canonical_name": "activation of T cell anergy"}
{"concept_id": "C2256010", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T cell anergy"}
{"concept_id": "C2256013", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of B cell anergy"}
{"concept_id": "C2256014", "aliases": [], "types": ["T043"], "canonical_name": "activation of B cell anergy"}
{"concept_id": "C2256015", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of B cell anergy"}
{"concept_id": "C2256018", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of acute inflammatory response"}
{"concept_id": "C2256019", "aliases": [], "types": ["T040"], "canonical_name": "activation of acute inflammatory response"}
{"concept_id": "C2256020", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of acute inflammatory response"}
{"concept_id": "C2256023", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of chronic inflammatory response"}
{"concept_id": "C2256024", "aliases": [], "types": ["T040"], "canonical_name": "activation of chronic inflammatory response"}
{"concept_id": "C2256025", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of chronic inflammatory response"}
{"concept_id": "C2256028", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of immune system process"}
{"concept_id": "C2256029", "aliases": [], "types": ["T039"], "canonical_name": "activation of immune system process"}
{"concept_id": "C2256030", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of immune system process"}
{"concept_id": "C2256033", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of leukocyte migration"}
{"concept_id": "C2256034", "aliases": [], "types": ["T043"], "canonical_name": "activation of leukocyte migration"}
{"concept_id": "C2256035", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of leukocyte migration"}
{"concept_id": "C2256038", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of leukocyte chemotaxis"}
{"concept_id": "C2256039", "aliases": [], "types": ["T043"], "canonical_name": "activation of leukocyte chemotaxis"}
{"concept_id": "C2256040", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of leukocyte chemotaxis"}
{"concept_id": "C2256043", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular extravasation"}
{"concept_id": "C2256044", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular extravasation"}
{"concept_id": "C2256045", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cellular extravasation"}
{"concept_id": "C2256048", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of leukocyte activation"}
{"concept_id": "C2256049", "aliases": [], "types": ["T039"], "canonical_name": "activation of leukocyte activation"}
{"concept_id": "C2256050", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of leukocyte activation"}
{"concept_id": "C2256053", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of immune effector process"}
{"concept_id": "C2256054", "aliases": [], "types": ["T039"], "canonical_name": "activation of immune effector process"}
{"concept_id": "C2256055", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of immune effector process"}
{"concept_id": "C2256058", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of production of molecular mediator of immune response"}
{"concept_id": "C2256059", "aliases": [], "types": ["T039"], "canonical_name": "activation of production of molecular mediator of immune response"}
{"concept_id": "C2256060", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of production of molecular mediator of immune response"}
{"concept_id": "C2256063", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of leukocyte mediated immunity"}
{"concept_id": "C2256064", "aliases": [], "types": ["T039"], "canonical_name": "activation of leukocyte mediated immunity"}
{"concept_id": "C2256065", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of leukocyte mediated immunity"}
{"concept_id": "C2256068", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of lymphocyte mediated immunity"}
{"concept_id": "C2256069", "aliases": [], "types": ["T039"], "canonical_name": "activation of lymphocyte mediated immunity"}
{"concept_id": "C2256070", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of lymphocyte mediated immunity"}
{"concept_id": "C2256073", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of T cell mediated immunity"}
{"concept_id": "C2256074", "aliases": [], "types": ["T040"], "canonical_name": "activation of T cell mediated immunity"}
{"concept_id": "C2256075", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of T cell mediated immunity"}
{"concept_id": "C2256078", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of B cell mediated immunity"}
{"concept_id": "C2256079", "aliases": [], "types": ["T040"], "canonical_name": "activation of B cell mediated immunity"}
{"concept_id": "C2256080", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of B cell mediated immunity"}
{"concept_id": "C2256083", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of natural killer cell mediated immunity"}
{"concept_id": "C2256084", "aliases": [], "types": ["T039"], "canonical_name": "activation of natural killer cell mediated immunity"}
{"concept_id": "C2256085", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of natural killer cell mediated immunity"}
{"concept_id": "C2256088", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of cytokine production during immune response"}
{"concept_id": "C2256089", "aliases": [], "types": ["T040"], "canonical_name": "activation of cytokine production during immune response"}
{"concept_id": "C2256090", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of cytokine production during immune response"}
{"concept_id": "C2256091", "aliases": ["upregulation of cytokine production during immune response", "up-regulation of cytokine production during immune response"], "types": ["T040"], "canonical_name": "up regulation of cytokine production during immune response"}
{"concept_id": "C2256093", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of B cell cytokine production"}
{"concept_id": "C2256094", "aliases": [], "types": ["T043"], "canonical_name": "activation of B cell cytokine production"}
{"concept_id": "C2256095", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of B cell cytokine production"}
{"concept_id": "C2256098", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell cytokine production"}
{"concept_id": "C2256099", "aliases": [], "types": ["T043"], "canonical_name": "activation of T cell cytokine production"}
{"concept_id": "C2256100", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T cell cytokine production"}
{"concept_id": "C2256103", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell cytokine production"}
{"concept_id": "C2256104", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell cytokine production"}
{"concept_id": "C2256105", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell cytokine production"}
{"concept_id": "C2256108", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dendritic cell cytokine production"}
{"concept_id": "C2256109", "aliases": [], "types": ["T043"], "canonical_name": "activation of dendritic cell cytokine production"}
{"concept_id": "C2256110", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of dendritic cell cytokine production"}
{"concept_id": "C2256113", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myeloid dendritic cell cytokine production"}
{"concept_id": "C2256114", "aliases": [], "types": ["T043"], "canonical_name": "activation of myeloid dendritic cell cytokine production"}
{"concept_id": "C2256115", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of myeloid dendritic cell cytokine production"}
{"concept_id": "C2256118", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of plasmacytoid dendritic cell cytokine production"}
{"concept_id": "C2256119", "aliases": [], "types": ["T043"], "canonical_name": "activation of plasmacytoid dendritic cell cytokine production"}
{"concept_id": "C2256120", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of plasmacytoid dendritic cell cytokine production"}
{"concept_id": "C2256132", "aliases": [], "types": ["T039"], "canonical_name": "activation of antimicrobial humoral response"}
{"concept_id": "C2256133", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antimicrobial humoral response"}
{"concept_id": "C2256136", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myeloid leukocyte differentiation"}
{"concept_id": "C2256137", "aliases": [], "types": ["T043"], "canonical_name": "activation of myeloid leukocyte differentiation"}
{"concept_id": "C2256138", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of myeloid leukocyte differentiation"}
{"concept_id": "C2256141", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antimicrobial peptide production"}
{"concept_id": "C2256143", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antibacterial peptide production"}
{"concept_id": "C2256145", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antifungal peptide production"}
{"concept_id": "C2256147", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of peptide secretion"}
{"concept_id": "C2256148", "aliases": [], "types": ["T043"], "canonical_name": "activation of peptide secretion"}
{"concept_id": "C2256149", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of peptide secretion"}
{"concept_id": "C2256152", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of antimicrobial peptide secretion"}
{"concept_id": "C2256153", "aliases": [], "types": ["T043"], "canonical_name": "activation of antimicrobial peptide secretion"}
{"concept_id": "C2256154", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of antimicrobial peptide secretion"}
{"concept_id": "C2256157", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of antibacterial peptide secretion"}
{"concept_id": "C2256158", "aliases": [], "types": ["T043"], "canonical_name": "activation of antibacterial peptide secretion"}
{"concept_id": "C2256159", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of antibacterial peptide secretion"}
{"concept_id": "C2256162", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of antifungal peptide secretion"}
{"concept_id": "C2256163", "aliases": [], "types": ["T043"], "canonical_name": "activation of antifungal peptide secretion"}
{"concept_id": "C2256164", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of antifungal peptide secretion"}
{"concept_id": "C2256166", "aliases": [], "types": ["T039"], "canonical_name": "activation of antibacterial peptide production"}
{"concept_id": "C2256167", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antibacterial peptide production"}
{"concept_id": "C2256169", "aliases": [], "types": ["T039"], "canonical_name": "activation of antifungal peptide production"}
{"concept_id": "C2256170", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antifungal peptide production"}
{"concept_id": "C2256173", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antimicrobial peptide biosynthetic process"}
{"concept_id": "C2256174", "aliases": [], "types": ["T039"], "canonical_name": "activation of antimicrobial peptide biosynthetic process"}
{"concept_id": "C2256175", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of antimicrobial peptide biosynthetic process"}
{"concept_id": "C2256178", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antibacterial peptide biosynthetic process"}
{"concept_id": "C2256180", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antifungal peptide biosynthetic process"}
{"concept_id": "C2256181", "aliases": [], "types": ["T044"], "canonical_name": "biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "definition": "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria. [GOC:add, PMID:11807545]"}
{"concept_id": "C2256182", "aliases": [], "types": ["T039"], "canonical_name": "regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "definition": "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria. [GOC:add]"}
{"concept_id": "C2256183", "aliases": ["down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria"], "types": ["T039"], "canonical_name": "negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria. [GOC:add]"}
{"concept_id": "C2256184", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria"}
{"concept_id": "C2256185", "aliases": [], "types": ["T044"], "canonical_name": "biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "definition": "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria. [GOC:add]"}
{"concept_id": "C2256186", "aliases": [], "types": ["T039"], "canonical_name": "regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "definition": "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria. [GOC:add]"}
{"concept_id": "C2256187", "aliases": ["downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria"], "types": ["T044"], "canonical_name": "negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria. [GOC:add]"}
{"concept_id": "C2256188", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria"}
{"concept_id": "C2256190", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of adaptive immune response"}
{"concept_id": "C2256191", "aliases": [], "types": ["T040"], "canonical_name": "activation of adaptive immune response"}
{"concept_id": "C2256192", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of adaptive immune response"}
{"concept_id": "C2256198", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of T-helper 1 type immune response"}
{"concept_id": "C2256199", "aliases": [], "types": ["T040"], "canonical_name": "activation of T-helper 1 type immune response"}
{"concept_id": "C2256200", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of T-helper 1 type immune response"}
{"concept_id": "C2256208", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of response to biotic stimulus"}
{"concept_id": "C2256209", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to biotic stimulus"}
{"concept_id": "C2256210", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of response to biotic stimulus"}
{"concept_id": "C2256213", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of response to tumor cell"}
{"concept_id": "C2256214", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to tumor cell"}
{"concept_id": "C2256215", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of response to tumor cell"}
{"concept_id": "C2256218", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of immune response to tumor cell"}
{"concept_id": "C2256219", "aliases": [], "types": ["T040"], "canonical_name": "activation of immune response to tumor cell"}
{"concept_id": "C2256220", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of immune response to tumor cell"}
{"concept_id": "C2256223", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell mediated immune response to tumor cell"}
{"concept_id": "C2256224", "aliases": [], "types": ["T040"], "canonical_name": "activation of T cell mediated immune response to tumor cell"}
{"concept_id": "C2256225", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of T cell mediated immune response to tumor cell"}
{"concept_id": "C2256228", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of tolerance induction to tumor cell"}
{"concept_id": "C2256229", "aliases": [], "types": ["T040"], "canonical_name": "activation of tolerance induction to tumor cell"}
{"concept_id": "C2256230", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of tolerance induction to tumor cell"}
{"concept_id": "C2256233", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell tolerance induction to tumor cell"}
{"concept_id": "C2256234", "aliases": [], "types": ["T040"], "canonical_name": "activation of T cell tolerance induction to tumor cell"}
{"concept_id": "C2256235", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of T cell tolerance induction to tumor cell"}
{"concept_id": "C2256238", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of peripheral T cell tolerance induction"}
{"concept_id": "C2256239", "aliases": [], "types": ["T040"], "canonical_name": "activation of peripheral T cell tolerance induction"}
{"concept_id": "C2256240", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of peripheral T cell tolerance induction"}
{"concept_id": "C2256243", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell mediated cytotoxicity directed against tumor cell target"}
{"concept_id": "C2256244", "aliases": [], "types": ["T043"], "canonical_name": "activation of T cell mediated cytotoxicity directed against tumor cell target"}
{"concept_id": "C2256245", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T cell mediated cytotoxicity directed against tumor cell target"}
{"concept_id": "C2256248", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell mediated immune response to tumor cell"}
{"concept_id": "C2256249", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell mediated immune response to tumor cell"}
{"concept_id": "C2256250", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell mediated immune response to tumor cell"}
{"concept_id": "C2256253", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target"}
{"concept_id": "C2256254", "aliases": [], "types": ["T043"], "canonical_name": "activation of natural killer cell mediated cytotoxicity directed against tumor cell target"}
{"concept_id": "C2256255", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target"}
{"concept_id": "C2256258", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of inflammatory response to antigenic stimulus"}
{"concept_id": "C2256259", "aliases": [], "types": ["T040"], "canonical_name": "activation of inflammatory response to antigenic stimulus"}
{"concept_id": "C2256260", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of inflammatory response to antigenic stimulus"}
{"concept_id": "C2256263", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of acute inflammatory response to antigenic stimulus"}
{"concept_id": "C2256264", "aliases": [], "types": ["T040"], "canonical_name": "activation of acute inflammatory response to antigenic stimulus"}
{"concept_id": "C2256265", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of acute inflammatory response to antigenic stimulus"}
{"concept_id": "C2256268", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of B cell deletion"}
{"concept_id": "C2256269", "aliases": [], "types": ["T043"], "canonical_name": "activation of B cell deletion"}
{"concept_id": "C2256270", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of B cell deletion"}
{"concept_id": "C2256273", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of natural killer cell tolerance induction"}
{"concept_id": "C2256274", "aliases": [], "types": ["T039"], "canonical_name": "activation of natural killer cell tolerance induction"}
{"concept_id": "C2256275", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of natural killer cell tolerance induction"}
{"concept_id": "C2256278", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of chronic inflammatory response to antigenic stimulus"}
{"concept_id": "C2256279", "aliases": [], "types": ["T040"], "canonical_name": "activation of chronic inflammatory response to antigenic stimulus"}
{"concept_id": "C2256280", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of chronic inflammatory response to antigenic stimulus"}
{"concept_id": "C2256283", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of acute inflammatory response to non-antigenic stimulus"}
{"concept_id": "C2256284", "aliases": [], "types": ["T040"], "canonical_name": "activation of acute inflammatory response to non-antigenic stimulus"}
{"concept_id": "C2256285", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of acute inflammatory response to non-antigenic stimulus"}
{"concept_id": "C2256288", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of chronic inflammatory response to non-antigenic stimulus"}
{"concept_id": "C2256289", "aliases": [], "types": ["T040"], "canonical_name": "activation of chronic inflammatory response to non-antigenic stimulus"}
{"concept_id": "C2256290", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of chronic inflammatory response to non-antigenic stimulus"}
{"concept_id": "C2256293", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of hypersensitivity"}
{"concept_id": "C2256294", "aliases": [], "types": ["T040"], "canonical_name": "activation of hypersensitivity"}
{"concept_id": "C2256295", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of hypersensitivity"}
{"concept_id": "C2256298", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of myeloid leukocyte mediated immunity"}
{"concept_id": "C2256299", "aliases": [], "types": ["T039"], "canonical_name": "activation of myeloid leukocyte mediated immunity"}
{"concept_id": "C2256300", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of myeloid leukocyte mediated immunity"}
{"concept_id": "C2256303", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of immunoglobulin mediated immune response"}
{"concept_id": "C2256304", "aliases": [], "types": ["T040"], "canonical_name": "activation of immunoglobulin mediated immune response"}
{"concept_id": "C2256305", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of immunoglobulin mediated immune response"}
{"concept_id": "C2256308", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of type II hypersensitivity"}
{"concept_id": "C2256309", "aliases": [], "types": ["T040"], "canonical_name": "activation of type II hypersensitivity"}
{"concept_id": "C2256310", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of type II hypersensitivity"}
{"concept_id": "C2256313", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of central B cell tolerance induction"}
{"concept_id": "C2256314", "aliases": [], "types": ["T039"], "canonical_name": "activation of central B cell tolerance induction"}
{"concept_id": "C2256315", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of central B cell tolerance induction"}
{"concept_id": "C2256318", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of central B cell deletion"}
{"concept_id": "C2256319", "aliases": [], "types": ["T043"], "canonical_name": "activation of central B cell deletion"}
{"concept_id": "C2256320", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of central B cell deletion"}
{"concept_id": "C2256322", "aliases": ["negative regulation of B cell apoptosis", "downregulation of B cell apoptosis", "down regulation of B cell apoptosis", "down-regulation of B cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of B cell apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C2256323", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of B cell apoptosis"}
{"concept_id": "C2256324", "aliases": [], "types": ["T043"], "canonical_name": "activation of B cell apoptosis"}
{"concept_id": "C2256325", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of B cell apoptosis"}
{"concept_id": "C2256328", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mature B cell apoptosis"}
{"concept_id": "C2256329", "aliases": [], "types": ["T043"], "canonical_name": "activation of mature B cell apoptosis"}
{"concept_id": "C2256330", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mature B cell apoptosis"}
{"concept_id": "C2256333", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of peripheral B cell deletion"}
{"concept_id": "C2256334", "aliases": [], "types": ["T043"], "canonical_name": "activation of peripheral B cell deletion"}
{"concept_id": "C2256335", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of peripheral B cell deletion"}
{"concept_id": "C2256338", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lymphocyte anergy"}
{"concept_id": "C2256339", "aliases": [], "types": ["T043"], "canonical_name": "activation of lymphocyte anergy"}
{"concept_id": "C2256340", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of lymphocyte anergy"}
{"concept_id": "C2256343", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of central B cell anergy"}
{"concept_id": "C2256344", "aliases": [], "types": ["T043"], "canonical_name": "activation of central B cell anergy"}
{"concept_id": "C2256345", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of central B cell anergy"}
{"concept_id": "C2256348", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of peripheral B cell anergy"}
{"concept_id": "C2256349", "aliases": [], "types": ["T043"], "canonical_name": "activation of peripheral B cell anergy"}
{"concept_id": "C2256350", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of peripheral B cell anergy"}
{"concept_id": "C2256353", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of humoral immune response"}
{"concept_id": "C2256354", "aliases": [], "types": ["T040"], "canonical_name": "activation of humoral immune response"}
{"concept_id": "C2256355", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of humoral immune response"}
{"concept_id": "C2256358", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of humoral immune response mediated by circulating immunoglobulin"}
{"concept_id": "C2256359", "aliases": [], "types": ["T040"], "canonical_name": "activation of humoral immune response mediated by circulating immunoglobulin"}
{"concept_id": "C2256360", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of humoral immune response mediated by circulating immunoglobulin"}
{"concept_id": "C2256362", "aliases": ["organ system process"], "types": ["T039"], "canonical_name": "system process", "definition": "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. [GOC:mtg_cardio]"}
{"concept_id": "C2256363", "aliases": [], "types": ["T039"], "canonical_name": "voluntary skeletal muscle contraction", "definition": "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control. [GOC:mtg_cardio, GOC:mtg_muscle]"}
{"concept_id": "C2256364", "aliases": [], "types": ["T039"], "canonical_name": "involuntary skeletal muscle contraction", "definition": "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control. [GOC:mtg_cardio, GOC:mtg_muscle]"}
{"concept_id": "C2256365", "aliases": [], "types": ["T039"], "canonical_name": "muscle system process", "definition": "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. [GOC:mtg_cardio]"}
{"concept_id": "C2256366", "aliases": [], "types": ["T039"], "canonical_name": "muscle physiological process"}
{"concept_id": "C2256367", "aliases": ["excretory system process"], "types": ["T039"], "canonical_name": "renal system process", "definition": "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2256368", "aliases": [], "types": ["T039"], "canonical_name": "kidney system process"}
{"concept_id": "C2256369", "aliases": ["heart process"], "types": ["T039"], "definition": "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:mtg_cardio]", "canonical_name": "cardiac process"}
{"concept_id": "C2256371", "aliases": [], "types": ["T039"], "canonical_name": "lymph circulation", "definition": "The flow of lymph through the body of an animal. [GOC:mtg_cardio]"}
{"concept_id": "C2256372", "aliases": ["vasculature process"], "types": ["T039"], "definition": "A circulatory process that occurs at the level of the vasculature. [GOC:mtg_cardio]", "canonical_name": "vascular process in circulatory system"}
{"concept_id": "C2256373", "aliases": [], "types": ["T039"], "canonical_name": "central nervous system control of baroreceptor feedback", "definition": "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris. [GOC:mtg_cardio, ISBN:0323031951]"}
{"concept_id": "C2256377", "aliases": [], "types": ["T040"], "canonical_name": "baroreceptor detection of increased arterial stretch", "definition": "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal. [GOC:mtg_cardio]"}
{"concept_id": "C2256378", "aliases": [], "types": ["T040"], "canonical_name": "baroreceptor detection of decreased arterial stretch", "definition": "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal. [GOC:mtg_cardio]"}
{"concept_id": "C2256379", "aliases": ["baroreceptor regulation of systemic arterial blood pressure"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by baroreceptor feedback", "definition": "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control. [GOC:dph, GOC:mtg_cardio, GOC:tb]"}
{"concept_id": "C2256380", "aliases": ["aortic arch baroreceptor control of systemic arterial blood pressure"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback", "definition": "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control. [GOC:dph, GOC:mtg_cardio, GOC:tb]"}
{"concept_id": "C2256381", "aliases": ["carotid body chemoreceptor response to lowering of systemic arterial blood pressure", "carotid body chemoreceptor regulation of systemic arterial blood pressure", "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling", "definition": "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. [GOC:dph, GOC:mtg_cardio, GOC:tb]"}
{"concept_id": "C2256382", "aliases": [], "types": ["T040"], "canonical_name": "vagal reflex"}
{"concept_id": "C2256383", "aliases": ["aortic body chemoreceptor regulation of systemic arterial blood pressure", "aortic body chemoreceptor response to lowering of systemic arterial blood pressure", "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling", "definition": "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. [GOC:dph, GOC:mtg_cardio, GOC:tb]"}
{"concept_id": "C2256385", "aliases": [], "types": ["T043"], "canonical_name": "detection of hydrogen ion", "definition": "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal. [GOC:mtg_cardio]"}
{"concept_id": "C2256386", "aliases": [], "types": ["T043"], "canonical_name": "detection of carbon dioxide", "definition": "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal. [GOC:mtg_cardio]"}
{"concept_id": "C2256387", "aliases": [], "types": ["T043"], "canonical_name": "detection of oxygen", "definition": "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. [GOC:mtg_cardio]"}
{"concept_id": "C2256395", "aliases": ["excitation of vasomotor center by aortic body chemoreceptor signalling"], "types": ["T044"], "canonical_name": "excitation of vasomotor center by aortic body chemoreceptor signaling", "definition": "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure. [GOC:mtg_cardio]"}
{"concept_id": "C2256396", "aliases": ["excitation of vasomotor center by carotid body chemoreceptor signalling"], "types": ["T040"], "canonical_name": "excitation of vasomotor center by carotid body chemoreceptor signaling", "definition": "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure. [GOC:mtg_cardio]"}
{"concept_id": "C2256397", "aliases": [], "types": ["T040"], "canonical_name": "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure"}
{"concept_id": "C2256398", "aliases": [], "types": ["T040"], "canonical_name": "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure"}
{"concept_id": "C2256399", "aliases": ["blood pressure regulation mediated by a chemical signal"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure mediated by a chemical signal", "definition": "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. [GOC:mtg_cardio]"}
{"concept_id": "C2256400", "aliases": ["blood pressure regulation by physical factors"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by physical factors", "definition": "The regulation of blood pressure mediated by detection of forces within the circulatory system. [GOC:mtg_cardio]"}
{"concept_id": "C2256401", "aliases": ["blood pressure regulation by stress relaxation"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by stress relaxation", "definition": "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs. [GOC:mtg_cardio, ISBN:0721643949]"}
{"concept_id": "C2256402", "aliases": ["regulation of blood pressure by adrenaline"], "types": ["T044"], "canonical_name": "regulation of systemic arterial blood pressure by epinephrine", "definition": "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine. [GOC:mtg_cardio]"}
{"concept_id": "C2256403", "aliases": [], "types": ["T044"], "canonical_name": "blood pressure regulation by epinephrine"}
{"concept_id": "C2256404", "aliases": ["regulation of blood pressure by noradrenaline"], "types": ["T044"], "canonical_name": "regulation of systemic arterial blood pressure by norepinephrine", "definition": "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine. [GOC:mtg_cardio]"}
{"concept_id": "C2256405", "aliases": [], "types": ["T044"], "canonical_name": "blood pressure regulation by norepinephrine"}
{"concept_id": "C2256406", "aliases": ["blood pressure regulation by capillary fluid shift"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by capillary fluid shift", "definition": "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment. [GOC:mtg_cardio, ISBN:0721643949]"}
{"concept_id": "C2256407", "aliases": ["blood pressure regulation by atrial natriuretic peptide"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by atrial natriuretic peptide", "definition": "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide. [GOC:mtg_cardio]"}
{"concept_id": "C2256408", "aliases": [], "types": ["T044"], "canonical_name": "blood pressure regulation by ANP"}
{"concept_id": "C2256409", "aliases": ["angiotensin mediated drinking behavior"], "types": ["T040"], "canonical_name": "angiotensin-mediated drinking behavior", "definition": "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst. [GOC:mtg_cardio]"}
{"concept_id": "C2256410", "aliases": [], "types": ["T040"], "canonical_name": "circadian regulation of systemic arterial blood pressure", "definition": "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256411", "aliases": [], "types": ["T040"], "canonical_name": "circadian regulation of heart rate", "definition": "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256412", "aliases": [], "types": ["T040"], "canonical_name": "circadian regulation of heart contraction rate"}
{"concept_id": "C2256413", "aliases": ["master pacemaker clock regulation of blood pressure", "SCN regulation of blood pressure"], "types": ["T040"], "canonical_name": "circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus", "definition": "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256414", "aliases": ["master pacemaker clock regulation of heart rate", "SCN regulation of heart rate"], "types": ["T042"], "canonical_name": "circadian regulation of heart rate by the suprachiasmatic nucleus", "definition": "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256415", "aliases": [], "types": ["T040"], "canonical_name": "circadian regulation of heart contraction rate by the suprachiasmatic nucleus"}
{"concept_id": "C2256416", "aliases": ["regulation of vascular smooth muscle contraction"], "types": ["T040"], "canonical_name": "regulation of vascular associated smooth muscle contraction", "definition": "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction. [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl]"}
{"concept_id": "C2256417", "aliases": ["chemical cardiac inotropy", "regulation of the force of heart muscle contraction by chemical signal"], "types": ["T040"], "canonical_name": "regulation of the force of heart contraction by chemical signal", "definition": "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256418", "aliases": ["hormonal cardiac inotropy", "hormonal regulation of the force of heart muscle contraction"], "types": ["T040"], "canonical_name": "hormonal regulation of the force of heart contraction", "definition": "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256419", "aliases": ["epinephrine cardiac inotropy", "adrenaline regulation of the strength of heart muscle contraction", "adrenaline cardiac inotropy", "increased force of heart contraction by epinephrine"], "types": ["T044"], "canonical_name": "positive regulation of the force of heart contraction by epinephrine", "definition": "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256420", "aliases": ["positive regulation of heart contraction by adrenaline", "positive regulation of heart contraction by epinephrine"], "types": ["T044"], "canonical_name": "positive regulation of heart contraction by adrenaline"}
{"concept_id": "C2256421", "aliases": ["decreased force of heart contraction by acetylcholine"], "types": ["T044"], "canonical_name": "negative regulation of the force of heart contraction by acetylcholine", "definition": "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256422", "aliases": ["norepinephrine cardiac inotropy", "increased force of heart contraction by norepinephrine", "noradrenaline cardiac inotropy", "noradrenaline regulation of the strength of heart muscle contraction"], "types": ["T044"], "canonical_name": "positive regulation of the force of heart contraction by norepinephrine", "definition": "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256423", "aliases": [], "types": ["T044"], "canonical_name": "increased force of heart contraction by adrenaline"}
{"concept_id": "C2256424", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heart contraction by norepinephrine"}
{"concept_id": "C2256425", "aliases": ["chemical cardiac chronotropy", "chemical signal regulation of heart rate"], "types": ["T040"], "canonical_name": "regulation of heart rate by chemical signal", "definition": "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine. [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb]"}
{"concept_id": "C2256426", "aliases": [], "types": ["T040"], "canonical_name": "chemical signal regulation of heart contraction rate"}
{"concept_id": "C2256427", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of heart rate by acetylcholine", "definition": "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256428", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of heart contraction rate by acetylcholine"}
{"concept_id": "C2256429", "aliases": ["regulation of the rate of heart contraction by hormone", "hormonal cardiac chronotropy"], "types": ["T040"], "canonical_name": "regulation of heart rate by hormone", "definition": "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256430", "aliases": ["adrenaline regulation of the rate of heart muscle contraction", "adrenaline cardiac chronotropy", "noradrenaline cardiac chronotropy", "positive regulation of heart rate by adrenaline", "epinephrine cardiac chronotropy", "positive regulation of heart rate by norepinephrine", "norepinephrine cardiac chronotropy", "noradrenaline regulation of the rate of heart muscle contraction"], "types": ["T044"], "canonical_name": "positive regulation of heart rate by epinephrine", "definition": "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256431", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heart contraction rate by epinephrine"}
{"concept_id": "C2256433", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heart contraction rate by norepinephrine"}
{"concept_id": "C2256434", "aliases": [], "types": ["T040"], "canonical_name": "circadian regulation of systemic arterial blood pressure by hormone", "definition": "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. [GOC:mtg_cardio]"}
{"concept_id": "C2256435", "aliases": ["blood pressure regulation by acetylcholine"], "types": ["T044"], "canonical_name": "regulation of systemic arterial blood pressure by acetylcholine", "definition": "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256436", "aliases": ["vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure"], "types": ["T044"], "canonical_name": "acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure", "definition": "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure. [GOC:mtg_cardio, GOC:rl]"}
{"concept_id": "C2256437", "aliases": [], "types": ["T044"], "canonical_name": "regulation of systemic arterial blood pressure by neurotransmitter", "definition": "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. [GOC:mtg_cardio]"}
{"concept_id": "C2256438", "aliases": ["renal control of blood pressure", "renal regulation of systemic arterial blood pressure"], "types": ["T039"], "canonical_name": "renal system process involved in regulation of systemic arterial blood pressure", "definition": "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, GOC:tb]"}
{"concept_id": "C2256439", "aliases": ["renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence", "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence"], "types": ["T039"], "canonical_name": "renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "definition": "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature. [GOC:mtg_cardio]"}
{"concept_id": "C2256440", "aliases": [], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure", "definition": "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:mtg_cardio]"}
{"concept_id": "C2256442", "aliases": ["renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system"], "types": ["T039"], "canonical_name": "renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure", "definition": "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system. [GOC:mtg_cardio]"}
{"concept_id": "C2256447", "aliases": ["blood pressure regulation by renin-angiotensin"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by renin-angiotensin", "definition": "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. [GOC:mtg_cardio]"}
{"concept_id": "C2256449", "aliases": ["angiotensin-mediated negative regulation of renal output", "angiotensin mediated negative regulation of renal output"], "types": ["T044"], "canonical_name": "negative regulation of renal output by angiotensin", "definition": "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney. [GOC:dph, GOC:mtg_cardio, GOC:tb]"}
{"concept_id": "C2256450", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of systemic arterial blood pressure", "definition": "The process that increases the force with which blood travels through the systemic arterial circulatory system. [GOC:mtg_cardio]"}
{"concept_id": "C2256451", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of systemic arterial blood pressure", "definition": "The process that reduces the force with which blood travels through the systemic arterial circulatory system. [GOC:mtg_cardio]"}
{"concept_id": "C2256452", "aliases": [], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by local renal renin-angiotensin", "definition": "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen. [GOC:mtg_cardio]"}
{"concept_id": "C2256453", "aliases": ["increased force of heart contraction by neuronal epinephrine", "increased force of heart contraction by epinephrine released from the nerve endings"], "types": ["T044"], "canonical_name": "positive regulation of the force of heart contraction by neuronal epinephrine", "definition": "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction. [GOC:mtg_cardio]"}
{"concept_id": "C2256454", "aliases": [], "types": ["T044"], "canonical_name": "increased force of heart contraction by neuronal adrenaline"}
{"concept_id": "C2256455", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heart contraction by neuronal epinephrine"}
{"concept_id": "C2256456", "aliases": ["increased force of heart contraction by epinephrine in the bloodstream"], "types": ["T044"], "canonical_name": "positive regulation of the force of heart contraction by circulating epinephrine", "definition": "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction. [GOC:mtg_cardio]"}
{"concept_id": "C2256457", "aliases": [], "types": ["T044"], "canonical_name": "increased force of heart contraction by circulating adrenaline"}
{"concept_id": "C2256458", "aliases": ["positive regulation of heart contraction by circulating epinephrine"], "types": ["T044"], "canonical_name": "positive regulation of heart contraction by circulating adrenaline"}
{"concept_id": "C2256459", "aliases": ["increased force of heart contraction by circulating epinephrine-norepinephrine", "increased force of heart contraction by epinephrine-norepinephrine in the blood stream", "increased force of heart contraction by circulating adrenaline-noradrenaline"], "types": ["T044"], "canonical_name": "positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine", "definition": "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream. [GOC:mtg_cardio]"}
{"concept_id": "C2256460", "aliases": ["positive regulation of heart contraction by circulating epinephrine-norepinephrine"], "types": ["T044"], "canonical_name": "positive regulation of heart contraction by circulating adrenaline-noradrenaline"}
{"concept_id": "C2256461", "aliases": ["increased force of heart contraction by neuronal adrenaline-noradrenaline", "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings", "increased force of heart contraction by neuronal epinephrine-norepinephrine"], "types": ["T044"], "canonical_name": "positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine", "definition": "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings. [GOC:mtg_cardio]"}
{"concept_id": "C2256462", "aliases": ["water homeostasis by the renal system"], "types": ["T042"], "canonical_name": "renal water homeostasis", "definition": "Renal process involved in the maintenance of an internal steady state of water in the body. [GOC:mtg_cardio]"}
{"concept_id": "C2256463", "aliases": ["negative regulation of renal water excretion"], "types": ["T043"], "canonical_name": "renal water retention", "definition": "The process in which renal water excretion is decreased. [GOC:mtg_cardio]"}
{"concept_id": "C2256464", "aliases": [], "types": ["T039"], "canonical_name": "regulation of glomerular filtration", "definition": "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. [GOC:mtg_cardio]"}
{"concept_id": "C2256465", "aliases": [], "types": ["T039"], "canonical_name": "pressure natriuresis", "definition": "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis). [GOC:mtg_cardio]"}
{"concept_id": "C2256466", "aliases": [], "types": ["T043"], "canonical_name": "renal sodium ion transport", "definition": "The directed movement of sodium ions (Na+) by the renal system. [GOC:mtg_cardio]"}
{"concept_id": "C2256467", "aliases": [], "types": ["T043"], "canonical_name": "renal water transport", "definition": "The directed movement of water (H2O) by the renal system. [GOC:mtg_cardio]"}
{"concept_id": "C2256468", "aliases": [], "types": ["T039"], "canonical_name": "tubuloglomerular feedback", "definition": "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus. [GOC:mtg_cardio]"}
{"concept_id": "C2256469", "aliases": ["positive regulation of the force of heart muscle contraction by chemical signal"], "types": ["T040"], "canonical_name": "positive regulation of the force of heart contraction by chemical signal", "definition": "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. [GOC:mtg_cardio]"}
{"concept_id": "C2256470", "aliases": [], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by endothelin", "definition": "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor. [GOC:mtg_cardio]"}
{"concept_id": "C2256471", "aliases": ["regulation of blood pressure by circulating adrenaline-noradrenaline"], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine", "definition": "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system. [GOC:mtg_cardio]"}
{"concept_id": "C2256474", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of glomerular filtration", "definition": "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. [GOC:mtg_cardio]"}
{"concept_id": "C2256475", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of glomerular filtration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. [GOC:mtg_cardio]"}
{"concept_id": "C2256476", "aliases": ["regulation of glomerular filtration by angiotensin"], "types": ["T044"], "canonical_name": "angiotensin-mediated regulation of glomerular filtration"}
{"concept_id": "C2256478", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of the force of heart contraction by chemical signal", "definition": "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. [GOC:mtg_cardio]"}
{"concept_id": "C2256479", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of the force of heart muscle contraction by chemical signal"}
{"concept_id": "C2256480", "aliases": ["increased force of heart contraction by circulating norepinephrine"], "types": ["T044"], "canonical_name": "positive regulation of the force of heart contraction by circulating norepinephrine", "definition": "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction. [GOC:mtg_cardio]"}
{"concept_id": "C2256481", "aliases": [], "types": ["T044"], "canonical_name": "increased force of heart contraction by circulating noradrenaline"}
{"concept_id": "C2256482", "aliases": ["increased force of heart contraction by neuronal norepinephrine"], "types": ["T044"], "canonical_name": "positive regulation of the force of heart contraction by neuronal norepinephrine", "definition": "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction. [GOC:mtg_cardio]"}
{"concept_id": "C2256483", "aliases": [], "types": ["T044"], "canonical_name": "increased force of heart contraction by neuronal noradrenaline"}
{"concept_id": "C2256484", "aliases": ["positive regulation of heart rate by circulating adrenaline"], "types": ["T044"], "canonical_name": "positive regulation of heart rate by circulating epinephrine", "definition": "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction. [GOC:mtg_cardio]"}
{"concept_id": "C2256485", "aliases": ["positive regulation of heart rate by neuronal adrenaline"], "types": ["T044"], "canonical_name": "positive regulation of heart rate by neuronal epinephrine", "definition": "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction. [GOC:mtg_cardio]"}
{"concept_id": "C2256486", "aliases": ["positive regulation of heart rate by neuronal noradrenaline"], "types": ["T044"], "canonical_name": "positive regulation of heart rate by neuronal norepinephrine", "definition": "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction. [GOC:mtg_cardio]"}
{"concept_id": "C2256487", "aliases": ["positive regulation of heart rate by circulating noradrenaline"], "types": ["T044"], "canonical_name": "positive regulation of heart rate by circulating norepinephrine", "definition": "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction. [GOC:mtg_cardio]"}
{"concept_id": "C2256488", "aliases": [], "types": ["T044"], "canonical_name": "regulation of vasoconstriction by epinephrine", "definition": "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings. [GOC:mtg_cardio]"}
{"concept_id": "C2256489", "aliases": [], "types": ["T044"], "canonical_name": "regulation of vasoconstriction by norepinephrine", "definition": "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings. [GOC:mtg_cardio]"}
{"concept_id": "C2256490", "aliases": ["regulation of vasoconstriction by circulating noradrenaline"], "types": ["T044"], "canonical_name": "regulation of vasoconstriction by circulating norepinephrine", "definition": "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream. [GOC:mtg_cardio]"}
{"concept_id": "C2256491", "aliases": ["regulation of vasoconstriction by neuronal noradrenaline"], "types": ["T044"], "canonical_name": "regulation of vasoconstriction by neuronal norepinephrine", "definition": "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings. [GOC:mtg_cardio]"}
{"concept_id": "C2256492", "aliases": ["regulation of vasoconstriction by neuronal adrenaline"], "types": ["T044"], "canonical_name": "regulation of vasoconstriction by neuronal epinephrine", "definition": "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings. [GOC:mtg_cardio]"}
{"concept_id": "C2256493", "aliases": ["regulation of vasoconstriction by circulating adrenaline"], "types": ["T044"], "canonical_name": "regulation of vasoconstriction by circulating epinephrine", "definition": "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream. [GOC:mtg_cardio]"}
{"concept_id": "C2256494", "aliases": ["regulation of vasodilation by adrenaline"], "types": ["T044"], "canonical_name": "regulation of vasodilation by epinephrine"}
{"concept_id": "C2256495", "aliases": ["regulation of vasodilation by noradrenaline"], "types": ["T044"], "canonical_name": "regulation of vasodilation by norepinephrine"}
{"concept_id": "C2256506", "aliases": [], "types": ["T044"], "canonical_name": "S-S rearrangase activity"}
{"concept_id": "C2256507", "aliases": [], "types": ["T044"], "canonical_name": "globulin G"}
{"concept_id": "C2256508", "aliases": [], "types": ["T044"], "canonical_name": "globulin G1"}
{"concept_id": "C2256509", "aliases": [], "types": ["T044"], "canonical_name": "lysozyme g"}
{"concept_id": "C2256511", "aliases": [], "types": ["T044"], "canonical_name": "PR1-lysozyme"}
{"concept_id": "C2256562", "aliases": [], "types": ["T044"], "canonical_name": "factor XIIIa"}
{"concept_id": "C2256563", "aliases": [], "types": ["T044"], "canonical_name": "fibrin stabilizing factor"}
{"concept_id": "C2256565", "aliases": [], "types": ["T044"], "canonical_name": "polyamine transglutaminase activity"}
{"concept_id": "C2256566", "aliases": ["TGase activity", "glutaminylpeptide gamma-glutamyltransferase activity", "protein-glutamine:amine gamma-glutamyltransferase", "protein-glutamine gamma-glutamyltransferase activity", "transglutaminase activity", "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. [EC:2.3.2.13, RESID:AA0124]", "canonical_name": "fibrinoligase activity"}
{"concept_id": "C2256568", "aliases": [], "types": ["T044"], "canonical_name": "tissue transglutaminase"}
{"concept_id": "C2256614", "aliases": [], "types": ["T044"], "canonical_name": "cytidine monophosphoacetylneuraminate-ganglioside GM3"}
{"concept_id": "C2256621", "aliases": [], "types": ["T044"], "canonical_name": "core 6-beta-GlcNAc-transferase A"}
{"concept_id": "C2256631", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III"}
{"concept_id": "C2256633", "aliases": [], "types": ["T044"], "canonical_name": "GalT activity"}
{"concept_id": "C2256636", "aliases": [], "types": ["T044"], "canonical_name": "thyroid galactosyltransferase activity"}
{"concept_id": "C2256637", "aliases": [], "types": ["T044"], "canonical_name": "thyroid glycoprotein beta-galactosyltransferase"}
{"concept_id": "C2256649", "aliases": ["CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity", "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity"], "types": ["T044"], "canonical_name": "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "definition": "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R. [EC:2.4.99.4]"}
{"concept_id": "C2256656", "aliases": [], "types": ["T044"], "canonical_name": "phytosterol methyltransferase activity"}
{"concept_id": "C2256662", "aliases": [], "types": ["T044"], "canonical_name": "SMT1 activity"}
{"concept_id": "C2256663", "aliases": [], "types": ["T044"], "canonical_name": "zymosterol-24-methyltransferase activity"}
{"concept_id": "C2256681", "aliases": [], "types": ["T044"], "canonical_name": "1-pyrroline dehydrogenase"}
{"concept_id": "C2256694", "aliases": [], "types": ["T044"], "canonical_name": "paramylon synthetase"}
{"concept_id": "C2256707", "aliases": [], "types": ["T044"], "canonical_name": "branching enzyme activity"}
{"concept_id": "C2256709", "aliases": [], "types": ["T044"], "canonical_name": "enzymatic branching factor"}
{"concept_id": "C2256711", "aliases": ["alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity", "Q-enzyme", "starch branching enzyme", "glucosan transglycosylase activity", "amylo-(1,4->1,6)-transglycosylase activity", "1,4-glucan-6-(1,4-glucano)-transferase activity", "glycogen branching enzyme activity", "enzyme Q", "branching glycosyltransferase activity", "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity", "amylo-(1,4 to 1,6)transglucosidase activity", "alpha-glucan-branching glycosyltransferase activity", "amylose isomerase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. [EC:2.4.1.18]", "canonical_name": "1,4-alpha-glucan branching enzyme activity"}
{"concept_id": "C2256712", "aliases": [], "types": ["T044"], "canonical_name": "plant branching enzyme"}
{"concept_id": "C2256713", "aliases": [], "types": ["T044"], "canonical_name": "corticosteroid 11beta-dehydrogenase"}
{"concept_id": "C2256723", "aliases": ["LDL-PLA(2) activity", "LDL-associated phospholipase A2"], "types": ["T044"], "canonical_name": "LDL-associated phospholipase A(2) activity"}
{"concept_id": "C2256725", "aliases": [], "types": ["T044"], "canonical_name": "LDL-PLA2"}
{"concept_id": "C2256726", "aliases": [], "types": ["T044"], "canonical_name": "PAF 2-acylhydrolase activity"}
{"concept_id": "C2256727", "aliases": [], "types": ["T044"], "canonical_name": "PAF acetylhydrolase activity"}
{"concept_id": "C2256728", "aliases": [], "types": ["T044"], "canonical_name": "platelet-activating factor acetylhydrolase activity"}
{"concept_id": "C2256741", "aliases": [], "types": ["T044"], "canonical_name": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate"}
{"concept_id": "C2256745", "aliases": [], "types": ["T044"], "canonical_name": "D-erythrose-4-phosphate-lyase activity"}
{"concept_id": "C2256748", "aliases": [], "types": ["T044"], "canonical_name": "DS-Co activity"}
{"concept_id": "C2256749", "aliases": [], "types": ["T044"], "canonical_name": "DS-Mn activity"}
{"concept_id": "C2256775", "aliases": [], "types": ["T044"], "canonical_name": "branched-chain acyl-CoA dehydrogenase activity"}
{"concept_id": "C2256777", "aliases": [], "types": ["T044"], "canonical_name": "3beta-HSDH"}
{"concept_id": "C2256805", "aliases": [], "types": ["T044"], "canonical_name": "beta-hydroxybutyrylcoenzyme A dehydrogenase activity"}
{"concept_id": "C2256815", "aliases": ["enoyl coenzyme A hydrase (D)"], "types": ["T044"], "canonical_name": "enoyl coenzyme A hydrase (D)"}
{"concept_id": "C2256827", "aliases": [], "types": ["T044"], "canonical_name": "beta-isopropylmalic enzyme"}
{"concept_id": "C2256841", "aliases": [], "types": ["T044"], "canonical_name": "BCOAD activity"}
{"concept_id": "C2256842", "aliases": ["BCKDH activity", "branched-chain ketoacid dehydrogenase activity", "branched-chain keto acid dehydrogenase activity"], "types": ["T044"], "canonical_name": "branched chain keto acid dehydrogenase activity"}
{"concept_id": "C2256843", "aliases": [], "types": ["T044"], "canonical_name": "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity"}
{"concept_id": "C2256844", "aliases": [], "types": ["T044"], "canonical_name": "branched-chain 2-keto acid dehydrogenase activity"}
{"concept_id": "C2256845", "aliases": [], "types": ["T044"], "canonical_name": "branched-chain 2-oxo acid dehydrogenase activity"}
{"concept_id": "C2256846", "aliases": ["dehydrogenase, branched chain alpha-keto acid activity"], "types": ["T044"], "canonical_name": "branched-chain alpha-keto acid dehydrogenase activity"}
{"concept_id": "C2256847", "aliases": [], "types": ["T044"], "canonical_name": "branched-chain alpha-oxo acid dehydrogenase activity"}
{"concept_id": "C2256868", "aliases": ["4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity", "GABA-2-oxoglutarate aminotransferase activity", "GABA-oxoglutarate transaminase activity", "gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity", "GABA-alpha-ketoglutarate transaminase activity", "gamma-aminobutyrate-alpha-ketoglutarate transaminase activity", "gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity", "GABA-2-oxoglutarate transaminase activity", "gamma-aminobutyric acid-2-oxoglutarate transaminase activity", "GABA-oxoglutarate aminotransferase activity", "gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity", "GABA-alpha-oxoglutarate aminotransferase activity", "4-aminobutanoate:2-oxoglutarate aminotransferase activity", "4-aminobutyrate-2-ketoglutarate aminotransferase activity", "GABA-alpha-ketoglutaric acid transaminase activity", "GABA-alpha-ketoglutarate aminotransferase activity", "4-aminobutyrate-2-oxoglutarate transaminase activity", "4-aminobutyrate-2-oxoglutarate aminotransferase activity", "gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "4-aminobutyrate:2-oxoglutarate transaminase activity", "definition": "Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. [EC:2.6.1.19, GOC:mah]"}
{"concept_id": "C2256874", "aliases": ["beta-alanine aminotransferase"], "types": ["T044"], "canonical_name": "beta-alanine aminotransferase"}
{"concept_id": "C2256948", "aliases": [], "types": ["T044"], "canonical_name": "phosphohexokinase activity"}
{"concept_id": "C2256980", "aliases": [], "types": ["T044"], "canonical_name": "myoadenylate deaminase activity"}
{"concept_id": "C2256992", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]"}
{"concept_id": "C2256996", "aliases": [], "types": ["T044"], "canonical_name": "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)"}
{"concept_id": "C2256997", "aliases": [], "types": ["T044"], "canonical_name": "citrate cleavage enzyme activity"}
{"concept_id": "C2256999", "aliases": [], "types": ["T044"], "canonical_name": "citric cleavage enzyme activity"}
{"concept_id": "C2257038", "aliases": [], "types": ["T044"], "canonical_name": "new yellow enzyme"}
{"concept_id": "C2257041", "aliases": ["DNA cytosine methylase activity"], "types": ["T045"], "canonical_name": "cytosine DNA methylase activity"}
{"concept_id": "C2257044", "aliases": [], "types": ["T045"], "canonical_name": "deoxyribonucleic methylase activity"}
{"concept_id": "C2257048", "aliases": [], "types": ["T045"], "canonical_name": "methylphosphotriester-DNA methyltransferase activity"}
{"concept_id": "C2257050", "aliases": [], "types": ["T045"], "canonical_name": "type II DNA methylase activity"}
{"concept_id": "C2257056", "aliases": [], "types": ["T045"], "canonical_name": "DNA polymerase gamma"}
{"concept_id": "C2257057", "aliases": ["DNA polymerase I"], "types": ["T045"], "canonical_name": "deoxyribonucleic polymerase I"}
{"concept_id": "C2257058", "aliases": [], "types": ["T045"], "canonical_name": "DNA polymerase II"}
{"concept_id": "C2257059", "aliases": [], "types": ["T045"], "canonical_name": "DNA polymerase III"}
{"concept_id": "C2257062", "aliases": [], "types": ["T045"], "canonical_name": "duplicase"}
{"concept_id": "C2257063", "aliases": [], "types": ["T045"], "canonical_name": "Klenow fragment"}
{"concept_id": "C2257064", "aliases": [], "types": ["T045"], "canonical_name": "sequenase"}
{"concept_id": "C2257065", "aliases": [], "types": ["T045"], "canonical_name": "Taq DNA polymerase"}
{"concept_id": "C2257066", "aliases": [], "types": ["T045"], "canonical_name": "Taq Pol I"}
{"concept_id": "C2257067", "aliases": [], "types": ["T045"], "canonical_name": "Tca DNA polymerase"}
{"concept_id": "C2257074", "aliases": ["RNA polymerase I activity", "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter"], "types": ["T045"], "canonical_name": "RNA polymerase I activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]"}
{"concept_id": "C2257075", "aliases": ["RNA polymerase II activity", "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "RNA polymerase II activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]"}
{"concept_id": "C2257076", "aliases": ["RNA polymerase III activity", "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter"], "types": ["T045"], "canonical_name": "RNA polymerase III activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]"}
{"concept_id": "C2257077", "aliases": [], "types": ["T045"], "canonical_name": "transcriptase"}
{"concept_id": "C2257084", "aliases": [], "types": ["T045"], "canonical_name": "DNA-photoreactivating enzyme"}
{"concept_id": "C2257086", "aliases": ["photoreactivating enzyme activity"], "types": ["T045"], "canonical_name": "PRE"}
{"concept_id": "C2257089", "aliases": ["alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)"], "types": ["T045"], "canonical_name": "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)"}
{"concept_id": "C2257090", "aliases": [], "types": ["T045"], "canonical_name": "deoxyribonucleate 3-methyladenine glycosidase II"}
{"concept_id": "C2257101", "aliases": [], "types": ["T045"], "canonical_name": "UV endonuclease"}
{"concept_id": "C2257108", "aliases": ["deoxyribonucleate ligase"], "types": ["T045"], "canonical_name": "deoxyribonucleate ligase"}
{"concept_id": "C2257109", "aliases": ["deoxyribonucleic acid joinase", "deoxyribonucleic acid repair enzyme"], "types": ["T045"], "canonical_name": "deoxyribonucleic acid joinase"}
{"concept_id": "C2257110", "aliases": ["deoxyribonucleic acid ligase"], "types": ["T045"], "canonical_name": "deoxyribonucleic acid ligase"}
{"concept_id": "C2257112", "aliases": [], "types": ["T045"], "canonical_name": "deoxyribonucleic acid-joining enzyme"}
{"concept_id": "C2257113", "aliases": ["deoxyribonucleic joinase", "deoxyribonucleic repair enzyme"], "types": ["T045"], "canonical_name": "deoxyribonucleic joinase"}
{"concept_id": "C2257114", "aliases": ["deoxyribonucleic ligase"], "types": ["T045"], "canonical_name": "deoxyribonucleic ligase"}
{"concept_id": "C2257116", "aliases": ["deoxyribonucleic-joining enzyme"], "types": ["T045"], "canonical_name": "deoxyribonucleic-joining enzyme"}
{"concept_id": "C2257117", "aliases": ["DNA joinase activity"], "types": ["T045"], "canonical_name": "DNA joinase activity"}
{"concept_id": "C2257118", "aliases": ["DNA-joining enzyme"], "types": ["T045"], "canonical_name": "DNA-joining enzyme"}
{"concept_id": "C2257122", "aliases": [], "types": ["T045"], "canonical_name": "sealase activity"}
{"concept_id": "C2257133", "aliases": [], "types": ["T045"], "canonical_name": "terminal addition enzyme activity"}
{"concept_id": "C2257137", "aliases": ["deoxyribonucleate topoisomerase"], "types": ["T045"], "canonical_name": "deoxyribonucleate topoisomerase"}
{"concept_id": "C2257138", "aliases": [], "types": ["T045"], "canonical_name": "nicking-closing enzyme activity"}
{"concept_id": "C2257139", "aliases": [], "types": ["T045"], "canonical_name": "omega-protein activity"}
{"concept_id": "C2257140", "aliases": [], "types": ["T045"], "canonical_name": "relaxing enzyme activity"}
{"concept_id": "C2257141", "aliases": [], "types": ["T045"], "canonical_name": "swivelase activity"}
{"concept_id": "C2257142", "aliases": [], "types": ["T045"], "canonical_name": "topoisomerase"}
{"concept_id": "C2257144", "aliases": [], "types": ["T045"], "canonical_name": "untwisting enzyme activity"}
{"concept_id": "C2257146", "aliases": ["DNA topoisomerase II", "deoxyribonucleic topoisomerase activity", "topoisomerase II", "DNA topoisomerase IV activity"], "types": ["T045"], "definition": "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo. [EC:5.99.1.-, PMID:11274059]", "canonical_name": "type II DNA topoisomerase activity"}
{"concept_id": "C2257157", "aliases": [], "types": ["T044"], "canonical_name": "guanylate reductase activity"}
{"concept_id": "C2257186", "aliases": [], "types": ["T044"], "canonical_name": "inosinate dehydrogenase activity"}
{"concept_id": "C2257191", "aliases": [], "types": ["T044"], "canonical_name": "inosinic acid dehydrogenase activity"}
{"concept_id": "C2257192", "aliases": [], "types": ["T044"], "canonical_name": "glucitol dehydrogenase activity"}
{"concept_id": "C2257208", "aliases": [], "types": ["T044"], "canonical_name": "lysosomal alpha-N-acetylglucosaminidase activity"}
{"concept_id": "C2257213", "aliases": [], "types": ["T044"], "canonical_name": "beta-1,4-GalT"}
{"concept_id": "C2257216", "aliases": [], "types": ["T044"], "canonical_name": "lactose synthetase A protein"}
{"concept_id": "C2257251", "aliases": [], "types": ["T044"], "canonical_name": "glucosylamidase activity"}
{"concept_id": "C2257268", "aliases": [], "types": ["T044"], "canonical_name": "DPN kinase activity"}
{"concept_id": "C2257274", "aliases": [], "types": ["T044"], "canonical_name": "ADP-ribosyl cyclase activity", "definition": "Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide. [GOC:dph, GOC:pad, GOC:PARL, PMID:11866528]"}
{"concept_id": "C2257292", "aliases": [], "types": ["T044"], "canonical_name": "NADH-menadione oxidoreductase activity"}
{"concept_id": "C2257295", "aliases": [], "types": ["T044"], "canonical_name": "NADH:cytochrome c oxidoreductase activity"}
{"concept_id": "C2257297", "aliases": ["type 1 dehydrogenase activity"], "types": ["T044"], "canonical_name": "type 1 dehydrogenase activity"}
{"concept_id": "C2257298", "aliases": [], "types": ["T044"], "canonical_name": "type I dehydrogenase activity"}
{"concept_id": "C2257302", "aliases": [], "types": ["T044"], "canonical_name": "menadione oxidoreductase activity"}
{"concept_id": "C2257303", "aliases": [], "types": ["T044"], "canonical_name": "menadione reductase activity"}
{"concept_id": "C2257304", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)H menadione reductase activity"}
{"concept_id": "C2257308", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)H: menadione oxidoreductase activity"}
{"concept_id": "C2257310", "aliases": [], "types": ["T044"], "canonical_name": "NADH-menadione reductase activity"}
{"concept_id": "C2257312", "aliases": [], "types": ["T044"], "canonical_name": "p-benzoquinone reductase activity"}
{"concept_id": "C2257313", "aliases": [], "types": ["T044"], "canonical_name": "phylloquinone reductase activity"}
{"concept_id": "C2257316", "aliases": [], "types": ["T044"], "canonical_name": "viologen accepting pyridine nucleotide oxidoreductase activity"}
{"concept_id": "C2257317", "aliases": ["vitamin-K reductase activity"], "types": ["T044"], "canonical_name": "vitamin K reductase activity"}
{"concept_id": "C2257323", "aliases": ["H+-thase"], "types": ["T044"], "canonical_name": "H+-thase"}
{"concept_id": "C2257324", "aliases": [], "types": ["T044"], "canonical_name": "NAD transhydrogenase"}
{"concept_id": "C2257325", "aliases": ["NADH transhydrogenase"], "types": ["T044"], "canonical_name": "NADH transhydrogenase"}
{"concept_id": "C2257326", "aliases": ["NADH-NADP-transhydrogenase"], "types": ["T044"], "canonical_name": "NADH-NADP-transhydrogenase"}
{"concept_id": "C2257327", "aliases": ["NADPH-NAD oxidoreductase"], "types": ["T044"], "canonical_name": "NADPH-NAD oxidoreductase"}
{"concept_id": "C2257328", "aliases": ["NADPH:NAD+ transhydrogenase", "NADPH-NAD transhydrogenase"], "types": ["T044"], "canonical_name": "NADPH-NAD transhydrogenase"}
{"concept_id": "C2257330", "aliases": ["nicotinamide adenine dinucleotide (phosphate) transhydrogenase"], "types": ["T044"], "canonical_name": "nicotinamide adenine dinucleotide (phosphate) transhydrogenase"}
{"concept_id": "C2257331", "aliases": [], "types": ["T044"], "canonical_name": "nicotinamide nucleotide transhydrogenase activity"}
{"concept_id": "C2257333", "aliases": ["pyridine nucleotide transferase"], "types": ["T044"], "canonical_name": "pyridine nucleotide transferase"}
{"concept_id": "C2257334", "aliases": ["pyridine nucleotide transhydrogenase activity"], "types": ["T044"], "canonical_name": "pyridine nucleotide transhydrogenase activity"}
{"concept_id": "C2257335", "aliases": [], "types": ["T044"], "canonical_name": "aldehyde reductase (NADPH-dependent) activity"}
{"concept_id": "C2257336", "aliases": [], "types": ["T044"], "canonical_name": "CPR activity"}
{"concept_id": "C2257337", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity"}
{"concept_id": "C2257339", "aliases": [], "types": ["T044"], "canonical_name": "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity"}
{"concept_id": "C2257340", "aliases": [], "types": ["T044"], "canonical_name": "FAD-cytochrome c reductase activity"}
{"concept_id": "C2257341", "aliases": [], "types": ["T044"], "canonical_name": "ferrihemoprotein P-450 reductase activity"}
{"concept_id": "C2257342", "aliases": [], "types": ["T044"], "canonical_name": "NADP--cytochrome c reductase activity"}
{"concept_id": "C2257343", "aliases": [], "types": ["T044"], "canonical_name": "NADP--cytochrome reductase activity"}
{"concept_id": "C2257344", "aliases": ["NADPH--ferricytochrome c oxidoreductase activity"], "types": ["T044"], "canonical_name": "NADPH--cytochrome c oxidoreductase activity"}
{"concept_id": "C2257349", "aliases": [], "types": ["T044"], "canonical_name": "NADPH-dependent cytochrome c reductase activity"}
{"concept_id": "C2257353", "aliases": ["reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity"], "types": ["T044"], "canonical_name": "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity"}
{"concept_id": "C2257354", "aliases": [], "types": ["T044"], "canonical_name": "TPNH(2) cytochrome c reductase activity"}
{"concept_id": "C2257355", "aliases": [], "types": ["T044"], "canonical_name": "TPNH-cytochrome c reductase activity"}
{"concept_id": "C2257361", "aliases": [], "types": ["T044"], "canonical_name": "old yellow enzyme"}
{"concept_id": "C2257368", "aliases": [], "types": ["T044"], "canonical_name": "quinone oxidoreductase activity"}
{"concept_id": "C2257369", "aliases": [], "types": ["T044"], "canonical_name": "zeta-crystallin activity"}
{"concept_id": "C2257379", "aliases": ["homoserine O-transsuccinylase activity"], "types": ["T044"], "canonical_name": "homoserine O-transsuccinylase activity"}
{"concept_id": "C2257380", "aliases": [], "types": ["T044"], "canonical_name": "homoserine transsuccinylase activity"}
{"concept_id": "C2257392", "aliases": [], "types": ["T045"], "canonical_name": "revertase activity"}
{"concept_id": "C2257399", "aliases": [], "types": ["T045"], "canonical_name": "PB1 proteins"}
{"concept_id": "C2257400", "aliases": [], "types": ["T045"], "canonical_name": "PB2 proteins"}
{"concept_id": "C2257401", "aliases": [], "types": ["T045"], "canonical_name": "phage f2 replicase"}
{"concept_id": "C2257402", "aliases": [], "types": ["T045"], "canonical_name": "polymerase L"}
{"concept_id": "C2257407", "aliases": [], "types": ["T045"], "canonical_name": "ribonucleic synthetase activity"}
{"concept_id": "C2257410", "aliases": [], "types": ["T045"], "canonical_name": "RNA synthetase activity"}
{"concept_id": "C2257417", "aliases": [], "types": ["T045"], "canonical_name": "ribonucleic ligase activity"}
{"concept_id": "C2257419", "aliases": [], "types": ["T044"], "canonical_name": "hydroxy-acid oxidase A activity"}
{"concept_id": "C2257420", "aliases": [], "types": ["T044"], "canonical_name": "hydroxy-acid oxidase B activity"}
{"concept_id": "C2257421", "aliases": [], "types": ["T044"], "canonical_name": "hydroxyacid oxidase A"}
{"concept_id": "C2257422", "aliases": ["L-2-hydroxy acid oxidase", "(S)-2-hydroxy-acid oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide. [RHEA:16789]", "canonical_name": "L-alpha-hydroxy acid oxidase"}
{"concept_id": "C2257444", "aliases": [], "types": ["T044"], "canonical_name": "acetylglucosamine 1-phosphate uridylyltransferase"}
{"concept_id": "C2257455", "aliases": [], "types": ["T044"], "canonical_name": "galactowaldenase activity"}
{"concept_id": "C2257490", "aliases": [], "types": ["T044"], "canonical_name": "thiolase II"}
{"concept_id": "C2257525", "aliases": [], "types": ["T044"], "canonical_name": "thiolase I"}
{"concept_id": "C2257552", "aliases": ["glycerophosphatase activity"], "types": ["T044"], "canonical_name": "glycerophosphatase activity"}
{"concept_id": "C2257554", "aliases": ["phosphomonoesterase activity"], "types": ["T044"], "canonical_name": "phosphomonoesterase activity"}
{"concept_id": "C2257555", "aliases": [], "types": ["T044"], "canonical_name": "uteroferrin"}
{"concept_id": "C2257565", "aliases": ["medium-chain acyl-CoA dehydrogenase activity", "MCAD activity"], "types": ["T044"], "canonical_name": "medium-chain-acyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2257584", "aliases": ["Transphosphoribosidase activity"], "types": ["T044"], "canonical_name": "transphosphoribosidase activity"}
{"concept_id": "C2257589", "aliases": [], "types": ["T044"], "canonical_name": "copper-translocating P-type ATPase activity"}
{"concept_id": "C2257599", "aliases": ["S-adenosylhomocysteine hydrolase activity"], "types": ["T044"], "canonical_name": "S-adenosylhomocysteine hydrolase activity"}
{"concept_id": "C2257602", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]"}
{"concept_id": "C2257610", "aliases": [], "types": ["T044"], "canonical_name": "7-keto-8-aminopelargonic acid"}
{"concept_id": "C2257625", "aliases": [], "types": ["T044"], "canonical_name": "myokinase activity"}
{"concept_id": "C2257648", "aliases": [], "types": ["T044"], "canonical_name": "L-alanine aminotransferase activity"}
{"concept_id": "C2257649", "aliases": [], "types": ["T044"], "canonical_name": "L-alanine transaminase activity"}
{"concept_id": "C2257651", "aliases": ["GPT", "glutamic--pyruvic transaminase activity", "L-alanine-alpha-ketoglutarate aminotransferase activity", "glutamic acid-pyruvic acid transaminase activity", "L-alanine:2-oxoglutarate aminotransferase activity", "alanine aminotransferase activity", "glutamic-pyruvic aminotransferase activity", "alanine-pyruvate aminotransferase activity", "glutamic--alanine transaminase activity", "alanine transaminase activity", "pyruvate-glutamate transaminase activity", "pyruvate-alanine aminotransferase activity", "ALT"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate. [EC:2.6.1.2, RHEA:19453]", "canonical_name": "alanine-alpha-ketoglutarate aminotransferase activity"}
{"concept_id": "C2257652", "aliases": [], "types": ["T044"], "canonical_name": "pyruvate transaminase activity"}
{"concept_id": "C2257654", "aliases": [], "types": ["T044"], "canonical_name": "aliphatic alcohol dehydrogenase"}
{"concept_id": "C2257655", "aliases": [], "types": ["T044"], "canonical_name": "ethanol dehydrogenase"}
{"concept_id": "C2257660", "aliases": [], "types": ["T044"], "canonical_name": "yeast alcohol dehydrogenase"}
{"concept_id": "C2257684", "aliases": [], "types": ["T044"], "canonical_name": "quinoline oxidase activity"}
{"concept_id": "C2257685", "aliases": ["aldose reductase activity", "aldehyde reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]", "canonical_name": "alditol:NADP+ 1-oxidoreductase activity"}
{"concept_id": "C2257686", "aliases": [], "types": ["T044"], "canonical_name": "polyol dehydrogenase (NADP(+)) activity"}
{"concept_id": "C2257687", "aliases": [], "types": ["T044"], "canonical_name": "mutarotase activity"}
{"concept_id": "C2257702", "aliases": ["amino acid acetyltransferase activity", "amino-acid N-acetyltransferase activity", "acetylglutamate acetylglutamate synthetase activity", "acetyl-CoA:L-glutamate N-acetyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+). [EC:2.3.1.1, RHEA:24292]", "canonical_name": "AGAS"}
{"concept_id": "C2257705", "aliases": ["N-acetylglutamate synthase activity"], "types": ["T044"], "canonical_name": "N-acetylglutamate synthase activity"}
{"concept_id": "C2257730", "aliases": [], "types": ["T044"], "canonical_name": "acylase I activity"}
{"concept_id": "C2257733", "aliases": [], "types": ["T044"], "canonical_name": "aminoacylase I activity"}
{"concept_id": "C2257734", "aliases": [], "types": ["T044"], "canonical_name": "benzamidase activity"}
{"concept_id": "C2257735", "aliases": [], "types": ["T044"], "canonical_name": "dehydropeptidase II activity"}
{"concept_id": "C2257737", "aliases": [], "types": ["T044"], "canonical_name": "histozyme activity"}
{"concept_id": "C2257743", "aliases": [], "types": ["T044"], "canonical_name": "glycine synthase activity"}
{"concept_id": "C2257744", "aliases": [], "types": ["T044"], "canonical_name": "glycine-cleavage system T-protein activity"}
{"concept_id": "C2257761", "aliases": [], "types": ["T044"], "canonical_name": "C-5-lipoxygenase activity"}
{"concept_id": "C2257764", "aliases": [], "types": ["T044"], "canonical_name": "leukotriene-A(4) synthase activity"}
{"concept_id": "C2257765", "aliases": [], "types": ["T044"], "canonical_name": "LTA synthase activity"}
{"concept_id": "C2257778", "aliases": [], "types": ["T044"], "canonical_name": "adenosine 5'-triphosphate:L-arginine"}
{"concept_id": "C2257805", "aliases": [], "types": ["T044"], "canonical_name": "melatonin rhythm enzyme activity"}
{"concept_id": "C2257806", "aliases": [], "types": ["T044"], "canonical_name": "serotonin acetylase activity"}
{"concept_id": "C2257807", "aliases": [], "types": ["T044"], "canonical_name": "serotonin acetyltransferase activity"}
{"concept_id": "C2257808", "aliases": [], "types": ["T044"], "canonical_name": "serotonin N-acetyltransferase activity"}
{"concept_id": "C2257818", "aliases": [], "types": ["T044"], "canonical_name": "formamidase I"}
{"concept_id": "C2257819", "aliases": [], "types": ["T044"], "canonical_name": "formamidase II"}
{"concept_id": "C2257833", "aliases": [], "types": ["T044"], "canonical_name": "sulfokinase activity"}
{"concept_id": "C2257834", "aliases": ["A-esterase activity"], "types": ["T044"], "canonical_name": "A-esterase activity"}
{"concept_id": "C2257842", "aliases": [], "types": ["T044"], "canonical_name": "paraoxon hydrolase activity"}
{"concept_id": "C2257843", "aliases": ["paraoxonase activity"], "types": ["T044"], "canonical_name": "paraoxonase activity"}
{"concept_id": "C2257846", "aliases": [], "types": ["T044"], "canonical_name": "aromatic esterase"}
{"concept_id": "C2257862", "aliases": [], "types": ["T044"], "canonical_name": "asparaginase II"}
{"concept_id": "C2257864", "aliases": [], "types": ["T044"], "canonical_name": "crasnitin"}
{"concept_id": "C2257869", "aliases": ["aspartic alpha-decarboxylase"], "types": ["T044"], "canonical_name": "aspartic alpha-decarboxylase"}
{"concept_id": "C2257876", "aliases": [], "types": ["T044"], "canonical_name": "aspartic acid aminotransferase activity"}
{"concept_id": "C2257877", "aliases": [], "types": ["T044"], "canonical_name": "aspartic aminotransferase activity"}
{"concept_id": "C2257878", "aliases": [], "types": ["T044"], "canonical_name": "aspartyl aminotransferase activity"}
{"concept_id": "C2257887", "aliases": [], "types": ["T044"], "canonical_name": "L-aspartate transaminase activity"}
{"concept_id": "C2257889", "aliases": ["L-aspartate-2-oxoglutarate aminotransferase activity", "glutamic-oxalacetic transaminase activity", "oxaloacetate transferase activity", "L-aspartate-alpha-ketoglutarate transaminase activity", "2-oxoglutarate-glutamate aminotransferase activity", "L-aspartate:2-oxoglutarate aminotransferase activity", "glutamate-oxalate transaminase activity", "aspartate-2-oxoglutarate transaminase activity", "glutamate oxaloacetate transaminase activity", "glutamate-oxalacetate aminotransferase activity", "AspT", "aspartate alpha-ketoglutarate transaminase activity", "oxaloacetate-aspartate aminotransferase activity", "AAT", "L-aspartate-2-ketoglutarate aminotransferase activity", "aspartate aminotransferase activity", "glutamic--aspartic transaminase activity", "L-aspartate-2-oxoglutarate-transaminase activity", "aspartate transaminase activity", "aspartate:2-oxoglutarate aminotransferase activity", "GOT (enzyme)", "glutamic-aspartic aminotransferase activity", "glutamic oxalic transaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. [EC:2.6.1.1]", "canonical_name": "glutamic--oxaloacetic transaminase activity"}
{"concept_id": "C2257892", "aliases": [], "types": ["T044"], "canonical_name": "L-aspartic aminotransferase activity"}
{"concept_id": "C2257895", "aliases": [], "types": ["T044"], "canonical_name": "transaminase A activity"}
{"concept_id": "C2257930", "aliases": [], "types": ["T044"], "canonical_name": "biotin-methylcrotonoyl-CoA-carboxylase synthetase"}
{"concept_id": "C2257946", "aliases": ["Ap(4)A hydrolase activity"], "types": ["T044"], "canonical_name": "Ap(4)A hydrolase activity"}
{"concept_id": "C2257947", "aliases": [], "types": ["T044"], "canonical_name": "Ap(4)Aase activity"}
{"concept_id": "C2257948", "aliases": ["Ap4A hydrolase activity"], "types": ["T044"], "canonical_name": "Ap4A hydrolase activity"}
{"concept_id": "C2257949", "aliases": [], "types": ["T044"], "canonical_name": "Ap4Aase activity"}
{"concept_id": "C2257950", "aliases": [], "types": ["T044"], "canonical_name": "bis(5'-guanosyl)-tetraphosphatase activity"}
{"concept_id": "C2257954", "aliases": [], "types": ["T044"], "canonical_name": "diadenosinetetraphosphatase (asymmetrical) activity"}
{"concept_id": "C2257955", "aliases": [], "types": ["T044"], "canonical_name": "diguanosinetetraphosphatase (asymmetrical) activity"}
{"concept_id": "C2257970", "aliases": ["2,3-bisphospho-D-glycerate 2-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "bisphosphoglycerate 2-phosphatase activity", "definition": "Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate. [RHEA:21904]"}
{"concept_id": "C2257978", "aliases": [], "types": ["T044"], "canonical_name": "transaminase B activity"}
{"concept_id": "C2257988", "aliases": [], "types": ["T044"], "canonical_name": "unsaturated acyl-CoA reductase activity"}
{"concept_id": "C2257993", "aliases": [], "types": ["T044"], "canonical_name": "carbamylphosphate synthetase I"}
{"concept_id": "C2258012", "aliases": [], "types": ["T044"], "canonical_name": "carbonic anhydrase A"}
{"concept_id": "C2258015", "aliases": [], "types": ["T044"], "canonical_name": "aldehyde reductase I activity"}
{"concept_id": "C2258020", "aliases": [], "types": ["T044"], "canonical_name": "prostaglandin 9-ketoreductase activity"}
{"concept_id": "C2258022", "aliases": [], "types": ["T044"], "canonical_name": "xenobiotic ketone reductase activity"}
{"concept_id": "C2258030", "aliases": [], "types": ["T044"], "canonical_name": "cocaine esterase activity"}
{"concept_id": "C2258031", "aliases": [], "types": ["T044"], "canonical_name": "B-esterase activity"}
{"concept_id": "C2258033", "aliases": [], "types": ["T044"], "canonical_name": "procaine esterase activity"}
{"concept_id": "C2258034", "aliases": [], "types": ["T044"], "canonical_name": "triacetin esterase"}
{"concept_id": "C2258035", "aliases": [], "types": ["T044"], "canonical_name": "vitamin A esterase"}
{"concept_id": "C2258044", "aliases": [], "types": ["T044"], "canonical_name": "carnitine palmitoyltransferase I"}
{"concept_id": "C2258045", "aliases": [], "types": ["T044"], "canonical_name": "carnitine palmitoyltransferase II"}
{"concept_id": "C2258046", "aliases": [], "types": ["T044"], "canonical_name": "carnitine palmitoyltransferase-A"}
{"concept_id": "C2258047", "aliases": [], "types": ["T044"], "canonical_name": "CPT I (outer membrane carnitine palmitoyl transferase)"}
{"concept_id": "C2258060", "aliases": [], "types": ["T044"], "canonical_name": "dopa oxidase"}
{"concept_id": "C2258064", "aliases": ["phenolase activity"], "types": ["T044"], "canonical_name": "phenolase activity"}
{"concept_id": "C2258066", "aliases": ["pyrocatechol oxidase"], "types": ["T044"], "canonical_name": "pyrocatechol oxidase"}
{"concept_id": "C2258103", "aliases": ["hydroxyphenylpyruvate synthase activity"], "types": ["T044"], "canonical_name": "hydroxyphenylpyruvate synthase activity"}
{"concept_id": "C2258108", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]"}
{"concept_id": "C2258112", "aliases": [], "types": ["T044"], "canonical_name": "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]"}
{"concept_id": "C2258114", "aliases": ["citrate synthase activity"], "types": ["T044"], "canonical_name": "citrate synthase activity", "definition": "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. [RHEA:16845]"}
{"concept_id": "C2258119", "aliases": ["condensing enzyme activity"], "types": ["T044"], "canonical_name": "condensing enzyme activity"}
{"concept_id": "C2258129", "aliases": [], "types": ["T044"], "canonical_name": "MiMi-CK"}
{"concept_id": "C2258131", "aliases": ["2',3'-cyclic nucleoside monophosphate phosphodiesterase"], "types": ["T044"], "canonical_name": "2',3'-cyclic nucleoside monophosphate phosphodiesterase"}
{"concept_id": "C2258133", "aliases": ["2',3'-cyclic nucleotide phosphohydrolase"], "types": ["T044"], "canonical_name": "2',3'-cyclic nucleotide phosphohydrolase"}
{"concept_id": "C2258135", "aliases": [], "types": ["T044"], "canonical_name": "cyclic-CMP phosphodiesterase activity"}
{"concept_id": "C2258145", "aliases": [], "types": ["T044"], "canonical_name": "cyclic AMP phosphodiesterase activity"}
{"concept_id": "C2258165", "aliases": [], "types": ["T044"], "canonical_name": "gamma-cystathionase activity"}
{"concept_id": "C2258166", "aliases": [], "types": ["T044"], "canonical_name": "homoserine deaminase activity"}
{"concept_id": "C2258167", "aliases": [], "types": ["T044"], "canonical_name": "homoserine deaminase-cystathionase activity"}
{"concept_id": "C2258168", "aliases": [], "types": ["T044"], "canonical_name": "homoserine dehydratase activity"}
{"concept_id": "C2258176", "aliases": [], "types": ["T044"], "canonical_name": "O-acetylserine (thiol)-lyase A activity"}
{"concept_id": "C2258195", "aliases": ["CMP kinase activity"], "types": ["T044"], "canonical_name": "CMP kinase activity", "definition": "Catalysis of the reaction: ATP + CMP = ADP + CDP. [RHEA:11600]"}
{"concept_id": "C2258198", "aliases": ["ATP:dCMP phosphotransferase activity", "dCMP kinase activity"], "types": ["T044"], "canonical_name": "dCMP kinase activity", "definition": "Catalysis of the reaction: ATP + dCMP = ADP + dCDP. [RHEA:25094]"}
{"concept_id": "C2258200", "aliases": [], "types": ["T044"], "canonical_name": "deoxycytidylate kinase activity"}
{"concept_id": "C2258208", "aliases": [], "types": ["T044"], "canonical_name": "complex IV (mitochondrial electron transport) activity"}
{"concept_id": "C2258209", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome a3 activity"}
{"concept_id": "C2258210", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome aa3 activity"}
{"concept_id": "C2258211", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome oxidase activity"}
{"concept_id": "C2258213", "aliases": [], "types": ["T044"], "canonical_name": "indophenol oxidase"}
{"concept_id": "C2258214", "aliases": [], "types": ["T044"], "canonical_name": "indophenolase"}
{"concept_id": "C2258216", "aliases": [], "types": ["T044"], "canonical_name": "Warburg's respiratory enzyme activity"}
{"concept_id": "C2258222", "aliases": [], "types": ["T044"], "canonical_name": "mesocytochrome c peroxidase azide"}
{"concept_id": "C2258223", "aliases": [], "types": ["T044"], "canonical_name": "mesocytochrome c peroxidase cyanate"}
{"concept_id": "C2258224", "aliases": [], "types": ["T044"], "canonical_name": "mesocytochrome c peroxidase cyanide"}
{"concept_id": "C2258236", "aliases": [], "types": ["T044"], "canonical_name": "D-enzyme activity"}
{"concept_id": "C2258238", "aliases": [], "types": ["T044"], "canonical_name": "dextrin glycosyltransferase activity"}
{"concept_id": "C2258240", "aliases": [], "types": ["T044"], "canonical_name": "disproportionating enzyme activity"}
{"concept_id": "C2258242", "aliases": [], "types": ["T044"], "canonical_name": "dextrin 6-alpha-D-glucosidase activity"}
{"concept_id": "C2258262", "aliases": [], "types": ["T044"], "canonical_name": "deoxyriboaldolase activity"}
{"concept_id": "C2258268", "aliases": [], "types": ["T044"], "canonical_name": "dephosphocoenzyme A kinase activity"}
{"concept_id": "C2258278", "aliases": [], "types": ["T044"], "canonical_name": "cholinephosphotransferase activity"}
{"concept_id": "C2258287", "aliases": [], "types": ["T044"], "canonical_name": "ATP:1,2-diacylglycerol 3-phosphotransferase activity"}
{"concept_id": "C2258288", "aliases": [], "types": ["T044"], "canonical_name": "ATP:diacylglycerol phosphotransferase activity"}
{"concept_id": "C2258290", "aliases": [], "types": ["T044"], "canonical_name": "diacylglycerol:ATP kinase activity"}
{"concept_id": "C2258300", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity"}
{"concept_id": "C2258302", "aliases": [], "types": ["T044"], "canonical_name": "putrescine (diamine)-acetylating enzyme activity"}
{"concept_id": "C2258303", "aliases": [], "types": ["T044"], "canonical_name": "putrescine acetylase activity"}
{"concept_id": "C2258304", "aliases": [], "types": ["T044"], "canonical_name": "putrescine acetyltransferase activity"}
{"concept_id": "C2258305", "aliases": [], "types": ["T044"], "canonical_name": "putrescine N-acetyltransferase activity"}
{"concept_id": "C2258306", "aliases": [], "types": ["T044"], "canonical_name": "spermidine acetyltransferase activity"}
{"concept_id": "C2258307", "aliases": [], "types": ["T044"], "canonical_name": "spermidine N(1)-acetyltransferase activity"}
{"concept_id": "C2258310", "aliases": [], "types": ["T044"], "canonical_name": "spermine acetyltransferase"}
{"concept_id": "C2258311", "aliases": [], "types": ["T044"], "canonical_name": "spermine N(1)-acetyltransferase"}
{"concept_id": "C2258312", "aliases": [], "types": ["T044"], "canonical_name": "spermine N-acetyltransferase"}
{"concept_id": "C2258328", "aliases": [], "types": ["T044"], "canonical_name": "E3 component of alpha-ketoacid dehydrogenase complexes activity"}
{"concept_id": "C2258329", "aliases": [], "types": ["T044"], "canonical_name": "glycine-cleavage system L-protein activity"}
{"concept_id": "C2258330", "aliases": [], "types": ["T044"], "canonical_name": "L-protein activity"}
{"concept_id": "C2258331", "aliases": [], "types": ["T044"], "canonical_name": "LDP-Glc activity"}
{"concept_id": "C2258332", "aliases": [], "types": ["T044"], "canonical_name": "LDP-Val activity"}
{"concept_id": "C2258361", "aliases": [], "types": ["T044"], "canonical_name": "dihydroorotate:ubiquinone oxidoreductase activity"}
{"concept_id": "C2258409", "aliases": [], "types": ["T044"], "canonical_name": "geranyl-diphosphate synthase activity"}
{"concept_id": "C2258437", "aliases": [], "types": ["T044"], "canonical_name": "dopachrome conversion factor activity"}
{"concept_id": "C2258448", "aliases": [], "types": ["T044"], "canonical_name": "tryosinase-related protein-2"}
{"concept_id": "C2258569", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent cysteine-type endopeptidase activity", "definition": "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. [GOC:mah]"}
{"concept_id": "C2258599", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin C-terminal hydrolase"}
{"concept_id": "C2258859", "aliases": [], "types": ["T044"], "canonical_name": "26S protease"}
{"concept_id": "C2258860", "aliases": [], "types": ["T044"], "canonical_name": "alkaline protease"}
{"concept_id": "C2258861", "aliases": [], "types": ["T044"], "canonical_name": "ingensin"}
{"concept_id": "C2258862", "aliases": [], "types": ["T044"], "canonical_name": "large multicatalytic protease"}
{"concept_id": "C2258863", "aliases": [], "types": ["T044"], "canonical_name": "lens neutral proteinase"}
{"concept_id": "C2258864", "aliases": [], "types": ["T044"], "canonical_name": "multicatalytic endopeptidase complex"}
{"concept_id": "C2258865", "aliases": [], "types": ["T044"], "canonical_name": "multicatalytic proteinase"}
{"concept_id": "C2258866", "aliases": [], "types": ["T044"], "canonical_name": "multicatalytic proteinase (complex)"}
{"concept_id": "C2258867", "aliases": [], "types": ["T044"], "canonical_name": "prosome"}
{"concept_id": "C2258868", "aliases": [], "types": ["T044"], "canonical_name": "proteasome endopeptidase complex"}
{"concept_id": "C2258869", "aliases": [], "types": ["T044"], "canonical_name": "tricorn protease"}
{"concept_id": "C2258870", "aliases": [], "types": ["T044"], "canonical_name": "tricorn proteinase"}
{"concept_id": "C2258898", "aliases": [], "types": ["T044"], "canonical_name": "phosphorylethanolamine transferase activity"}
{"concept_id": "C2258912", "aliases": ["metaphosphatase activity"], "types": ["T044"], "canonical_name": "metaphosphatase activity"}
{"concept_id": "C2258915", "aliases": [], "types": ["T044"], "canonical_name": "farnesyltransferase activity"}
{"concept_id": "C2258918", "aliases": ["squalene synthetase activity"], "types": ["T044"], "canonical_name": "squalene synthase activity", "definition": "Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate. [EC:2.5.1.21]"}
{"concept_id": "C2258932", "aliases": [], "types": ["T044"], "canonical_name": "malonyl transacylase activity"}
{"concept_id": "C2258933", "aliases": [], "types": ["T044"], "canonical_name": "malonyl transferase activity"}
{"concept_id": "C2258947", "aliases": ["KAS I activity", "beta-ketoacyl-ACP synthase I activity", "3-oxoacyl:ACP synthase I", "3-oxoacyl-acyl carrier protein synthase I activity", "KASI"], "types": ["T044"], "canonical_name": "beta-ketoacyl-acyl-carrier-protein synthase I"}
{"concept_id": "C2258949", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid condensing enzyme activity"}
{"concept_id": "C2258958", "aliases": ["NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity", "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity", "3-oxoacyl-[acyl-carrier protein] reductase activity", "beta-ketoacyl-acyl carrier protein reductase activity", "3-oxoacyl-acyl-carrier-protein reductase activity", "3-oxoacyl-ACPreductase activity", "beta-ketoacyl thioester reductase activity", "3-oxoacyl-ACP reductase activity", "beta-ketoacyl acyl carrier protein (ACP) reductase activity", "beta-ketoacyl reductase activity", "3-ketoacyl acyl carrier protein reductase activity", "beta-ketoacyl-ACP reductase activity", "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity", "definition": "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. [RHEA:17397]"}
{"concept_id": "C2258974", "aliases": [], "types": ["T044"], "canonical_name": "yeast fatty acid synthase activity"}
{"concept_id": "C2258978", "aliases": [], "types": ["T044"], "canonical_name": "ferroxidase I"}
{"concept_id": "C2259032", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of coagulation"}
{"concept_id": "C2259033", "aliases": [], "types": ["T039"], "canonical_name": "activation of coagulation"}
{"concept_id": "C2259034", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of coagulation"}
{"concept_id": "C2259037", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of calcium-mediated signaling"}
{"concept_id": "C2259038", "aliases": [], "types": ["T040"], "canonical_name": "activation of calcium-mediated signaling"}
{"concept_id": "C2259039", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of calcium-mediated signaling"}
{"concept_id": "C2259041", "aliases": [], "types": ["T044"], "canonical_name": "activation of antigen receptor-mediated signaling pathway"}
{"concept_id": "C2259042", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of antigen receptor-mediated signaling pathway"}
{"concept_id": "C2259045", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of antigen receptor-mediated signaling pathway"}
{"concept_id": "C2259047", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of B cell receptor signaling pathway"}
{"concept_id": "C2259049", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of T cell receptor signaling pathway"}
{"concept_id": "C2259050", "aliases": [], "types": ["T040"], "canonical_name": "activation of B cell receptor signaling pathway"}
{"concept_id": "C2259051", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of B cell receptor signaling pathway"}
{"concept_id": "C2259053", "aliases": [], "types": ["T044"], "canonical_name": "activation of T cell receptor signaling pathway"}
{"concept_id": "C2259054", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of T cell receptor signaling pathway"}
{"concept_id": "C2259057", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell activation"}
{"concept_id": "C2259058", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell activation"}
{"concept_id": "C2259059", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell activation"}
{"concept_id": "C2259062", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell activation"}
{"concept_id": "C2259064", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of B cell activation"}
{"concept_id": "C2259065", "aliases": [], "types": ["T043"], "canonical_name": "activation of T cell activation"}
{"concept_id": "C2259066", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of T cell activation"}
{"concept_id": "C2259068", "aliases": [], "types": ["T043"], "canonical_name": "activation of B cell activation"}
{"concept_id": "C2259069", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of B cell activation"}
{"concept_id": "C2259071", "aliases": [], "types": ["T039"], "canonical_name": "regulation of body fluid levels", "definition": "Any process that modulates the levels of body fluids. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2259072", "aliases": ["multicellular organismal locomotion"], "types": ["T039"], "canonical_name": "multicellular organismal movement", "definition": "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. [GOC:dph, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2259073", "aliases": [], "types": ["T040"], "canonical_name": "neuromuscular process controlling balance", "definition": "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. [GOC:ai, GOC:dph]"}
{"concept_id": "C2259074", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organismal water homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. [GOC:dph, GOC:tb]"}
{"concept_id": "C2259075", "aliases": [], "types": ["T043"], "canonical_name": "activation of chemotaxis"}
{"concept_id": "C2259076", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of chemotaxis"}
{"concept_id": "C2259079", "aliases": [], "types": ["T043"], "canonical_name": "activation of negative chemotaxis"}
{"concept_id": "C2259080", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of negative chemotaxis"}
{"concept_id": "C2259083", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of negative chemotaxis"}
{"concept_id": "C2259084", "aliases": [], "types": ["T043"], "canonical_name": "activation of positive chemotaxis"}
{"concept_id": "C2259085", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of positive chemotaxis"}
{"concept_id": "C2259088", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of positive chemotaxis"}
{"concept_id": "C2259091", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pigment cell differentiation"}
{"concept_id": "C2259092", "aliases": [], "types": ["T043"], "canonical_name": "activation of pigment cell differentiation"}
{"concept_id": "C2259093", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of pigment cell differentiation"}
{"concept_id": "C2259096", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of iridophore differentiation"}
{"concept_id": "C2259098", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of xanthophore differentiation"}
{"concept_id": "C2259099", "aliases": [], "types": ["T043"], "canonical_name": "activation of iridophore differentiation"}
{"concept_id": "C2259100", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of iridophore differentiation"}
{"concept_id": "C2259102", "aliases": [], "types": ["T043"], "canonical_name": "activation of xanthophore differentiation"}
{"concept_id": "C2259103", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of xanthophore differentiation"}
{"concept_id": "C2259106", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of early stripe melanocyte differentiation"}
{"concept_id": "C2259107", "aliases": [], "types": ["T043"], "canonical_name": "activation of early stripe melanocyte differentiation"}
{"concept_id": "C2259108", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of early stripe melanocyte differentiation"}
{"concept_id": "C2259111", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of late stripe melanocyte differentiation"}
{"concept_id": "C2259112", "aliases": [], "types": ["T043"], "canonical_name": "activation of late stripe melanocyte differentiation"}
{"concept_id": "C2259113", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of late stripe melanocyte differentiation"}
{"concept_id": "C2259117", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lipid catabolic process"}
{"concept_id": "C2259118", "aliases": [], "types": ["T040"], "canonical_name": "activation of lipid catabolic process"}
{"concept_id": "C2259119", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of lipid catabolic process"}
{"concept_id": "C2259121", "aliases": [], "types": ["T040"], "canonical_name": "activation of nitric-oxide synthase activity"}
{"concept_id": "C2259122", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of nitric-oxide synthase activity"}
{"concept_id": "C2259125", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of nitric-oxide synthase activity"}
{"concept_id": "C2259127", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of lipoprotein lipase activity"}
{"concept_id": "C2259128", "aliases": [], "types": ["T040"], "canonical_name": "activation of lipoprotein lipase activity"}
{"concept_id": "C2259129", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of lipoprotein lipase activity"}
{"concept_id": "C2259137", "aliases": [], "types": ["T039"], "canonical_name": "regulation of endosome size", "definition": "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. [GOC:ai]"}
{"concept_id": "C2259138", "aliases": [], "types": ["T039"], "canonical_name": "endosome enlargement"}
{"concept_id": "C2259144", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium-independent cell-cell adhesion"}
{"concept_id": "C2259145", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of calcium-independent cell-cell adhesion"}
{"concept_id": "C2259148", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcium-independent cell-cell adhesion"}
{"concept_id": "C2259149", "aliases": [], "types": ["T043"], "canonical_name": "activation of membrane protein ectodomain proteolysis"}
{"concept_id": "C2259150", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of membrane protein ectodomain proteolysis"}
{"concept_id": "C2259153", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane protein ectodomain proteolysis"}
{"concept_id": "C2259154", "aliases": [], "types": ["T043"], "canonical_name": "activation of secretion"}
{"concept_id": "C2259155", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of secretion"}
{"concept_id": "C2259158", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of secretion"}
{"concept_id": "C2259159", "aliases": [], "types": ["T043"], "canonical_name": "activation of transport"}
{"concept_id": "C2259160", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of transport"}
{"concept_id": "C2259163", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of transport"}
{"concept_id": "C2259165", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA metabolic process"}
{"concept_id": "C2259166", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA metabolic process"}
{"concept_id": "C2259167", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of DNA metabolic process"}
{"concept_id": "C2259171", "aliases": [], "types": ["T040"], "canonical_name": "activation of small GTPase mediated signal transduction"}
{"concept_id": "C2259172", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of small GTPase mediated signal transduction"}
{"concept_id": "C2259175", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of small GTPase mediated signal transduction"}
{"concept_id": "C2259176", "aliases": [], "types": ["T044"], "canonical_name": "bacterial debranching enzyme"}
{"concept_id": "C2259179", "aliases": ["R-enzyme"], "types": ["T044"], "canonical_name": "R-enzyme"}
{"concept_id": "C2259181", "aliases": ["'de novo' posttranslational protein folding"], "types": ["T044"], "canonical_name": "'de novo' post-translational protein folding", "definition": "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. [GOC:rb]"}
{"concept_id": "C2259182", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription factor activity"}
{"concept_id": "C2259185", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of developmental process"}
{"concept_id": "C2259186", "aliases": [], "types": ["T039"], "canonical_name": "activation of developmental process"}
{"concept_id": "C2259187", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of developmental process"}
{"concept_id": "C2259189", "aliases": [], "types": ["T040"], "canonical_name": "activation of helicase activity"}
{"concept_id": "C2259190", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of helicase activity"}
{"concept_id": "C2259193", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of helicase activity"}
{"concept_id": "C2259194", "aliases": [], "types": ["T044"], "canonical_name": "activation of binding"}
{"concept_id": "C2259195", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of binding"}
{"concept_id": "C2259198", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of binding"}
{"concept_id": "C2259199", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA ligation"}
{"concept_id": "C2259200", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of DNA ligation"}
{"concept_id": "C2259203", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA ligation"}
{"concept_id": "C2259212", "aliases": [], "types": ["T044"], "canonical_name": "sugar transmembrane transporter activity", "definition": "Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2259214", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of actin nucleation"}
{"concept_id": "C2259215", "aliases": [], "types": ["T044"], "canonical_name": "activation of actin nucleation"}
{"concept_id": "C2259216", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of actin nucleation"}
{"concept_id": "C2259222", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of NK T cell activation"}
{"concept_id": "C2259223", "aliases": [], "types": ["T043"], "canonical_name": "activation of NK T cell activation"}
{"concept_id": "C2259224", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of NK T cell activation"}
{"concept_id": "C2259227", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of NK T cell differentiation"}
{"concept_id": "C2259228", "aliases": [], "types": ["T043"], "canonical_name": "activation of NK T cell differentiation"}
{"concept_id": "C2259229", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of NK T cell differentiation"}
{"concept_id": "C2259232", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of NK T cell proliferation"}
{"concept_id": "C2259233", "aliases": [], "types": ["T043"], "canonical_name": "activation of NK T cell proliferation"}
{"concept_id": "C2259234", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of NK T cell proliferation"}
{"concept_id": "C2259237", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of muscle cell differentiation"}
{"concept_id": "C2259238", "aliases": [], "types": ["T043"], "canonical_name": "activation of muscle cell differentiation"}
{"concept_id": "C2259239", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of muscle cell differentiation"}
{"concept_id": "C2259242", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of smooth muscle cell differentiation"}
{"concept_id": "C2259243", "aliases": [], "types": ["T043"], "canonical_name": "activation of smooth muscle cell differentiation"}
{"concept_id": "C2259244", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of smooth muscle cell differentiation"}
{"concept_id": "C2259247", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of striated muscle cell differentiation"}
{"concept_id": "C2259248", "aliases": [], "types": ["T043"], "canonical_name": "activation of striated muscle cell differentiation"}
{"concept_id": "C2259249", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of striated muscle cell differentiation"}
{"concept_id": "C2259251", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nitrogen metabolic process"}
{"concept_id": "C2259252", "aliases": [], "types": ["T040"], "canonical_name": "activation of nitrogen metabolic process"}
{"concept_id": "C2259253", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of nitrogen metabolic process"}
{"concept_id": "C2259255", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sulfur metabolic process"}
{"concept_id": "C2259256", "aliases": [], "types": ["T044"], "canonical_name": "activation of sulfur metabolic process"}
{"concept_id": "C2259257", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of sulfur metabolic process"}
{"concept_id": "C2259274", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein transport"}
{"concept_id": "C2259275", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein transport"}
{"concept_id": "C2259278", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein transport"}
{"concept_id": "C2259279", "aliases": ["spindle assembly involved in meiosis"], "types": ["T043"], "canonical_name": "meiotic spindle assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis. [GOC:tb, GOC:vw]"}
{"concept_id": "C2259293", "aliases": [], "types": ["T039"], "canonical_name": "activation of multicellular organismal process"}
{"concept_id": "C2259294", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of multicellular organismal process"}
{"concept_id": "C2259297", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of multicellular organismal process"}
{"concept_id": "C2259299", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular defense response"}
{"concept_id": "C2259300", "aliases": [], "types": ["T040"], "canonical_name": "activation of protein metabolic process"}
{"concept_id": "C2259301", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of protein metabolic process"}
{"concept_id": "C2259304", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein metabolic process"}
{"concept_id": "C2259306", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lymphocyte activation"}
{"concept_id": "C2259307", "aliases": [], "types": ["T043"], "canonical_name": "activation of lymphocyte activation"}
{"concept_id": "C2259308", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of lymphocyte activation"}
{"concept_id": "C2259311", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of RNA metabolic process"}
{"concept_id": "C2259312", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA metabolic process"}
{"concept_id": "C2259313", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of RNA metabolic process"}
{"concept_id": "C2259321", "aliases": [], "types": ["T045"], "canonical_name": "maintenance of genome integrity"}
{"concept_id": "C2259324", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of release of sequestered calcium ion into cytosol"}
{"concept_id": "C2259325", "aliases": [], "types": ["T043"], "canonical_name": "activation of release of sequestered calcium ion into cytosol"}
{"concept_id": "C2259326", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of release of sequestered calcium ion into cytosol"}
{"concept_id": "C2259329", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sequestering of calcium ion"}
{"concept_id": "C2259330", "aliases": [], "types": ["T043"], "canonical_name": "activation of sequestering of calcium ion"}
{"concept_id": "C2259331", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of sequestering of calcium ion"}
{"concept_id": "C2259333", "aliases": [], "types": ["T040"], "canonical_name": "activation of cyclic nucleotide phosphodiesterase activity"}
{"concept_id": "C2259334", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of cyclic nucleotide phosphodiesterase activity"}
{"concept_id": "C2259335", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of cyclic nucleotide phosphodiesterase activity"}
{"concept_id": "C2259336", "aliases": [], "types": ["T040"], "canonical_name": "activation of hydrolase activity"}
{"concept_id": "C2259337", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of hydrolase activity"}
{"concept_id": "C2259340", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of hydrolase activity"}
{"concept_id": "C2259341", "aliases": [], "types": ["T040"], "canonical_name": "activation of transferase activity"}
{"concept_id": "C2259342", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of transferase activity"}
{"concept_id": "C2259345", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of transferase activity"}
{"concept_id": "C2259346", "aliases": [], "types": ["T040"], "canonical_name": "activation of lyase activity"}
{"concept_id": "C2259347", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of lyase activity"}
{"concept_id": "C2259350", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of lyase activity"}
{"concept_id": "C2259351", "aliases": [], "types": ["T040"], "canonical_name": "activation of ligase activity"}
{"concept_id": "C2259352", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of ligase activity"}
{"concept_id": "C2259355", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of ligase activity"}
{"concept_id": "C2259356", "aliases": [], "types": ["T040"], "canonical_name": "activation of oxidoreductase activity"}
{"concept_id": "C2259357", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of oxidoreductase activity"}
{"concept_id": "C2259360", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of oxidoreductase activity"}
{"concept_id": "C2259362", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nerve growth factor receptor signaling pathway"}
{"concept_id": "C2259363", "aliases": [], "types": ["T040"], "canonical_name": "activation of nerve growth factor receptor signaling pathway"}
{"concept_id": "C2259364", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of nerve growth factor receptor signaling pathway"}
{"concept_id": "C2259367", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nerve growth factor receptor activity"}
{"concept_id": "C2259368", "aliases": [], "types": ["T044"], "canonical_name": "activation of nerve growth factor receptor activity"}
{"concept_id": "C2259369", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of nerve growth factor receptor activity"}
{"concept_id": "C2259391", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of endo-1,4-beta-xylanase activity"}
{"concept_id": "C2259392", "aliases": [], "types": ["T040"], "canonical_name": "activation of endo-1,4-beta-xylanase activity"}
{"concept_id": "C2259393", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of endo-1,4-beta-xylanase activity"}
{"concept_id": "C2259402", "aliases": [], "types": ["T043"], "canonical_name": "activation of progression through meiotic cell cycle"}
{"concept_id": "C2259403", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of progression through meiotic cell cycle"}
{"concept_id": "C2259404", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of progression through meiotic cell cycle"}
{"concept_id": "C2259405", "aliases": [], "types": ["T043"], "canonical_name": "intracellular acidification"}
{"concept_id": "C2259410", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cortisol secretion"}
{"concept_id": "C2259411", "aliases": [], "types": ["T043"], "canonical_name": "activation of cortisol secretion"}
{"concept_id": "C2259412", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cortisol secretion"}
{"concept_id": "C2259415", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of corticotropin-releasing hormone secretion"}
{"concept_id": "C2259416", "aliases": [], "types": ["T043"], "canonical_name": "activation of corticotropin-releasing hormone secretion"}
{"concept_id": "C2259417", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of corticotropin-releasing hormone secretion"}
{"concept_id": "C2259419", "aliases": [], "types": ["T044"], "canonical_name": "glucosylglycerol transmembrane transporter activity", "definition": "Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2259420", "aliases": [], "types": ["T044"], "canonical_name": "mannosylglycerate transmembrane transporter activity", "definition": "Enables the transfer of a mannosylglycerate from one side of a membrane to the other. [GOC:ai, PMID:15034926]"}
{"concept_id": "C2259422", "aliases": ["negative regulation of filopodia biosynthesis", "down regulation of filopodium formation", "down-regulation of filopodium formation", "inhibition of filopodium formation", "negative regulation of filopodium formation", "negative regulation of filopodia formation", "downregulation of filopodium formation"], "types": ["T043"], "canonical_name": "negative regulation of filopodium assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai]"}
{"concept_id": "C2259423", "aliases": ["positive regulation of filopodia formation", "activation of filopodium formation", "positive regulation of filopodia biosynthesis", "positive regulation of filopodium formation", "upregulation of filopodium formation", "stimulation of filopodium formation", "up regulation of filopodium formation", "up-regulation of filopodium formation"], "types": ["T043"], "canonical_name": "positive regulation of filopodium assembly", "definition": "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2259431", "aliases": [], "types": ["T043"], "canonical_name": "activation of stress fiber formation"}
{"concept_id": "C2259432", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of stress fiber formation"}
{"concept_id": "C2259433", "aliases": ["up regulation of stress fiber formation", "up-regulation of stress fiber formation", "upregulation of stress fiber formation"], "types": ["T043"], "canonical_name": "positive regulation of stress fiber assembly", "definition": "Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai]"}
{"concept_id": "C2259434", "aliases": ["down regulation of stress fiber formation", "downregulation of stress fiber formation", "down-regulation of stress fiber formation"], "types": ["T043"], "canonical_name": "negative regulation of stress fiber assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai]"}
{"concept_id": "C2259435", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of stress fiber formation"}
{"concept_id": "C2259437", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of unidimensional cell growth"}
{"concept_id": "C2259438", "aliases": [], "types": ["T043"], "canonical_name": "activation of unidimensional cell growth"}
{"concept_id": "C2259439", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of unidimensional cell growth"}
{"concept_id": "C2259442", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of monopolar cell growth"}
{"concept_id": "C2259443", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of monopolar cell growth"}
{"concept_id": "C2259446", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of bipolar cell growth"}
{"concept_id": "C2259447", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of bipolar cell growth"}
{"concept_id": "C2259454", "aliases": [], "types": ["T043"], "canonical_name": "activation of elastin biosynthetic process"}
{"concept_id": "C2259455", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of elastin biosynthetic process"}
{"concept_id": "C2259458", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of elastin biosynthetic process"}
{"concept_id": "C2259460", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of keratinocyte migration"}
{"concept_id": "C2259461", "aliases": [], "types": ["T043"], "canonical_name": "activation of keratinocyte migration"}
{"concept_id": "C2259462", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of keratinocyte migration"}
{"concept_id": "C2259465", "aliases": [], "types": ["T040"], "canonical_name": "activation of histone H3-K4 methylation"}
{"concept_id": "C2259466", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of histone H3-K4 methylation"}
{"concept_id": "C2259469", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H3-K4 methylation"}
{"concept_id": "C2259471", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H3-K9 methylation"}
{"concept_id": "C2259472", "aliases": [], "types": ["T045"], "canonical_name": "activation of histone H3-K9 methylation"}
{"concept_id": "C2259473", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of histone H3-K9 methylation"}
{"concept_id": "C2259476", "aliases": [], "types": ["T043"], "canonical_name": "activation of neurotransmitter uptake"}
{"concept_id": "C2259477", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neurotransmitter uptake"}
{"concept_id": "C2259484", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neurotransmitter transport"}
{"concept_id": "C2259485", "aliases": [], "types": ["T043"], "canonical_name": "activation of neurotransmitter transport"}
{"concept_id": "C2259486", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neurotransmitter transport"}
{"concept_id": "C2259490", "aliases": [], "types": ["T043"], "canonical_name": "activation of serotonin uptake"}
{"concept_id": "C2259491", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of serotonin uptake"}
{"concept_id": "C2259494", "aliases": [], "types": ["T043"], "canonical_name": "activation of histamine uptake"}
{"concept_id": "C2259495", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of histamine uptake"}
{"concept_id": "C2259498", "aliases": [], "types": ["T043"], "canonical_name": "activation of norepinephrine uptake"}
{"concept_id": "C2259499", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of norepinephrine uptake"}
{"concept_id": "C2259502", "aliases": [], "types": ["T043"], "canonical_name": "activation of epinephrine uptake"}
{"concept_id": "C2259503", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of epinephrine uptake"}
{"concept_id": "C2259506", "aliases": [], "types": ["T043"], "canonical_name": "activation of acetylcholine uptake"}
{"concept_id": "C2259507", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of acetylcholine uptake"}
{"concept_id": "C2259516", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of killing of cells of another organism"}
{"concept_id": "C2259517", "aliases": [], "types": ["T043"], "canonical_name": "activation of killing of cells of another organism"}
{"concept_id": "C2259518", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of killing of cells of another organism"}
{"concept_id": "C2259519", "aliases": ["up regulation of killing of cells of another organism", "up-regulation of killing of cells of another organism", "upregulation of killing of cells of another organism", "positive regulation of killing of cells of other organism"], "types": ["T043"], "canonical_name": "positive regulation of killing of cells of another organism", "definition": "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism. [GOC:ai]"}
{"concept_id": "C2259521", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytolysis of cells of another organism"}
{"concept_id": "C2259522", "aliases": [], "types": ["T043"], "canonical_name": "activation of cytolysis of cells of another organism"}
{"concept_id": "C2259523", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cytolysis of cells of another organism"}
{"concept_id": "C2259526", "aliases": ["HpaII methylase"], "types": ["T045"], "canonical_name": "HpaII' methylase"}
{"concept_id": "C2259527", "aliases": [], "types": ["T045"], "canonical_name": "M.BsuRIa"}
{"concept_id": "C2259528", "aliases": [], "types": ["T045"], "canonical_name": "M.BsuRIb"}
{"concept_id": "C2259544", "aliases": [], "types": ["T043"], "canonical_name": "activation of nitric-oxide synthase biosynthetic process"}
{"concept_id": "C2259545", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of nitric-oxide synthase biosynthetic process"}
{"concept_id": "C2259548", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nitric-oxide synthase biosynthetic process"}
{"concept_id": "C2259551", "aliases": ["upregulation of nitric-oxide synthase 2 biosynthetic process", "up-regulation of nitric-oxide synthase 2 biosynthetic process"], "types": ["T043"], "canonical_name": "up regulation of nitric-oxide synthase 2 biosynthetic process"}
{"concept_id": "C2259552", "aliases": ["down-regulation of nitric-oxide synthase 2 biosynthetic process", "downregulation of nitric-oxide synthase 2 biosynthetic process"], "types": ["T043"], "canonical_name": "down regulation of nitric-oxide synthase 2 biosynthetic process"}
{"concept_id": "C2259553", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nitric-oxide synthase 2 biosynthetic process"}
{"concept_id": "C2259555", "aliases": [], "types": ["T039"], "canonical_name": "activation of cell division"}
{"concept_id": "C2259556", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of cell division"}
{"concept_id": "C2259559", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cell division"}
{"concept_id": "C2259561", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of nuclear division"}
{"concept_id": "C2259562", "aliases": [], "types": ["T039"], "canonical_name": "activation of nuclear division"}
{"concept_id": "C2259563", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of nuclear division"}
{"concept_id": "C2259567", "aliases": [], "types": ["T040"], "canonical_name": "activation of catagen"}
{"concept_id": "C2259568", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of catagen"}
{"concept_id": "C2259571", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of catagen"}
{"concept_id": "C2259572", "aliases": [], "types": ["T039"], "canonical_name": "activation of hair follicle development"}
{"concept_id": "C2259573", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of hair follicle development"}
{"concept_id": "C2259576", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of hair follicle development"}
{"concept_id": "C2259583", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of synapse structural plasticity"}
{"concept_id": "C2259584", "aliases": [], "types": ["T042"], "canonical_name": "activation of synapse structural plasticity"}
{"concept_id": "C2259585", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of synapse structural plasticity"}
{"concept_id": "C2259588", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by host of cytolysis of symbiont cells"}
{"concept_id": "C2259589", "aliases": [], "types": ["T040"], "canonical_name": "activation by host of cytolysis of symbiont cells"}
{"concept_id": "C2259590", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by host of cytolysis of symbiont cells"}
{"concept_id": "C2259599", "aliases": [], "types": ["T040"], "canonical_name": "activation of anagen"}
{"concept_id": "C2259600", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of anagen"}
{"concept_id": "C2259603", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of anagen"}
{"concept_id": "C2259604", "aliases": [], "types": ["T040"], "canonical_name": "activation of exogen"}
{"concept_id": "C2259605", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of exogen"}
{"concept_id": "C2259608", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of exogen"}
{"concept_id": "C2259609", "aliases": [], "types": ["T043"], "canonical_name": "activation of cardioblast differentiation"}
{"concept_id": "C2259610", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cardioblast differentiation"}
{"concept_id": "C2259613", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardioblast differentiation"}
{"concept_id": "C2259614", "aliases": [], "types": ["T043"], "canonical_name": "activation of focal adhesion formation"}
{"concept_id": "C2259615", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of focal adhesion formation"}
{"concept_id": "C2259618", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of focal adhesion formation"}
{"concept_id": "C2259619", "aliases": [], "types": ["T040"], "canonical_name": "activation of protein kinase B signaling cascade"}
{"concept_id": "C2259620", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of protein kinase B signaling cascade"}
{"concept_id": "C2259623", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of protein kinase B signaling cascade"}
{"concept_id": "C2259624", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitochondrial depolarization"}
{"concept_id": "C2259625", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mitochondrial depolarization"}
{"concept_id": "C2259628", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitochondrial depolarization"}
{"concept_id": "C2259629", "aliases": [], "types": ["T044"], "canonical_name": "ADH3 activity"}
{"concept_id": "C2259630", "aliases": [], "types": ["T044"], "canonical_name": "chi-ADH activity"}
{"concept_id": "C2259631", "aliases": [], "types": ["T044"], "canonical_name": "class III alcohol dehydrogenase activity"}
{"concept_id": "C2259632", "aliases": [], "types": ["T044"], "canonical_name": "FDH activity"}
{"concept_id": "C2259633", "aliases": [], "types": ["T044"], "canonical_name": "formic dehydrogenase activity"}
{"concept_id": "C2259644", "aliases": [], "types": ["T044"], "canonical_name": "soluble heterodisulfide reductase activity"}
{"concept_id": "C2259645", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of synaptic plasticity by chemical substance"}
{"concept_id": "C2259648", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of fibrinolysis"}
{"concept_id": "C2259649", "aliases": [], "types": ["T042"], "canonical_name": "activation of fibrinolysis"}
{"concept_id": "C2259650", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of fibrinolysis"}
{"concept_id": "C2259657", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcium ion transport"}
{"concept_id": "C2259661", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium ion transport"}
{"concept_id": "C2259663", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of calcium ion transport"}
{"concept_id": "C2259667", "aliases": ["down-regulation of amino acid uptake during transmission of nerve impulse", "downregulation of amino acid uptake during transmission of nerve impulse"], "types": ["T043"], "canonical_name": "down regulation of amino acid uptake during transmission of nerve impulse"}
{"concept_id": "C2259668", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of amino acid uptake during transmission of nerve impulse"}
{"concept_id": "C2259669", "aliases": [], "types": ["T043"], "canonical_name": "activation of amino acid uptake during transmission of nerve impulse"}
{"concept_id": "C2259670", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of amino acid uptake during transmission of nerve impulse"}
{"concept_id": "C2259671", "aliases": ["upregulation of amino acid uptake during transmission of nerve impulse", "up-regulation of amino acid uptake during transmission of nerve impulse"], "types": ["T043"], "canonical_name": "up regulation of amino acid uptake during transmission of nerve impulse"}
{"concept_id": "C2259672", "aliases": [], "types": ["T043"], "canonical_name": "activation of catecholamine uptake during transmission of nerve impulse"}
{"concept_id": "C2259673", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of catecholamine uptake during transmission of nerve impulse"}
{"concept_id": "C2259674", "aliases": ["upregulation of catecholamine uptake during transmission of nerve impulse", "positive regulation of catecholamine neurotransmitter uptake", "up-regulation of catecholamine uptake during transmission of nerve impulse", "up regulation of catecholamine uptake during transmission of nerve impulse", "positive regulation of catecholamine neurotransmitter reuptake"], "types": ["T043"], "canonical_name": "positive regulation of catecholamine uptake involved in synaptic transmission", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2259675", "aliases": ["down regulation of catecholamine uptake during transmission of nerve impulse", "negative regulation of catecholamine neurotransmitter reuptake", "negative regulation of catecholamine neurotransmitter uptake", "downregulation of catecholamine uptake during transmission of nerve impulse", "down-regulation of catecholamine uptake during transmission of nerve impulse"], "types": ["T043"], "canonical_name": "negative regulation of catecholamine uptake involved in synaptic transmission", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2259676", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of catecholamine uptake during transmission of nerve impulse"}
{"concept_id": "C2259677", "aliases": ["down regulation of glutamate uptake during transmission of nerve impulse", "down-regulation of glutamate uptake during transmission of nerve impulse", "downregulation of glutamate uptake during transmission of nerve impulse", "negative regulation of glutamate reuptake"], "types": ["T043"], "canonical_name": "negative regulation of glutamate uptake involved in transmission of nerve impulse", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C2259678", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glutamate uptake during transmission of nerve impulse"}
{"concept_id": "C2259679", "aliases": ["down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse", "negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse", "negative regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse", "negative regulation of GABA uptake during transmission of nerve impulse", "negative regulation of 4-aminobutyrate reuptake", "negative regulation of GABA reuptake", "down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse", "downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse", "negative regulation of gamma-aminobutyric acid reuptake"], "types": ["T043"], "canonical_name": "negative regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C2259680", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse"}
{"concept_id": "C2259681", "aliases": [], "types": ["T043"], "canonical_name": "activation of gamma-aminobutyric acid uptake during transmission of nerve impulse"}
{"concept_id": "C2259682", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse"}
{"concept_id": "C2259683", "aliases": ["positive regulation of GABA reuptake", "upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse", "positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse", "positive regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse", "positive regulation of 4-aminobutyrate reuptake", "positive regulation of GABA uptake during transmission of nerve impulse", "up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse", "up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse", "positive regulation of gamma-aminobutyric acid reuptake"], "types": ["T043"], "canonical_name": "positive regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C2259684", "aliases": [], "types": ["T043"], "canonical_name": "activation of glutamate uptake during transmission of nerve impulse"}
{"concept_id": "C2259685", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of glutamate uptake during transmission of nerve impulse"}
{"concept_id": "C2259686", "aliases": ["up-regulation of glutamate uptake during transmission of nerve impulse", "positive regulation of glutamate reuptake", "positive regulation of glutamate uptake involved in conduction of nerve impulse", "up regulation of glutamate uptake during transmission of nerve impulse", "upregulation of glutamate uptake during transmission of nerve impulse"], "types": ["T043"], "canonical_name": "positive regulation of glutamate uptake involved in transmission of nerve impulse", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. [GOC:ai]"}
{"concept_id": "C2259688", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amine transport"}
{"concept_id": "C2259689", "aliases": [], "types": ["T040"], "canonical_name": "activation of amine transport"}
{"concept_id": "C2259690", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of amine transport"}
{"concept_id": "C2259693", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of amino acid transport"}
{"concept_id": "C2259694", "aliases": [], "types": ["T044"], "canonical_name": "activation of amino acid transport"}
{"concept_id": "C2259695", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of amino acid transport"}
{"concept_id": "C2259698", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of nervous system development"}
{"concept_id": "C2259699", "aliases": [], "types": ["T039"], "canonical_name": "activation of nervous system development"}
{"concept_id": "C2259700", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of nervous system development"}
{"concept_id": "C2259708", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of synaptic transmission, glutamatergic"}
{"concept_id": "C2259709", "aliases": [], "types": ["T042"], "canonical_name": "activation of synaptic transmission, glutamatergic"}
{"concept_id": "C2259710", "aliases": [], "types": ["T042"], "canonical_name": "stimulation of synaptic transmission, glutamatergic"}
{"concept_id": "C2259713", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of transmission of nerve impulse"}
{"concept_id": "C2259714", "aliases": [], "types": ["T040"], "canonical_name": "activation of transmission of nerve impulse"}
{"concept_id": "C2259715", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of transmission of nerve impulse"}
{"concept_id": "C2259717", "aliases": [], "types": ["T040"], "canonical_name": "activation of telomerase activity"}
{"concept_id": "C2259718", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of telomerase activity"}
{"concept_id": "C2259721", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomerase activity"}
{"concept_id": "C2259722", "aliases": [], "types": ["T045"], "canonical_name": "activation of chromosome segregation"}
{"concept_id": "C2259723", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of chromosome segregation"}
{"concept_id": "C2259726", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of chromosome segregation"}
{"concept_id": "C2259728", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of attachment of spindle microtubules to kinetochore"}
{"concept_id": "C2259729", "aliases": [], "types": ["T043"], "canonical_name": "activation of attachment of spindle microtubules to kinetochore"}
{"concept_id": "C2259730", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of attachment of spindle microtubules to kinetochore"}
{"concept_id": "C2259733", "aliases": ["radical SAM enzyme activity"], "types": ["T044"], "canonical_name": "radical SAM enzyme activity"}
{"concept_id": "C2259735", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway"}
{"concept_id": "C2259739", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host ethylene-mediated defense response"}
{"concept_id": "C2259740", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of hormone or growth regulator levels in host"}
{"concept_id": "C2259741", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of hormone or growth regulator levels in host"}
{"concept_id": "C2259743", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of host signal transduction pathway"}
{"concept_id": "C2259744", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host signal transduction pathway"}
{"concept_id": "C2259747", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host signal transduction pathway"}
{"concept_id": "C2259748", "aliases": ["suppression of PAMP-induced host innate immunity", "suppression of pathogen-associated molecular pattern-induced host innate immunity", "downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity", "negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immunity", "suppression of MAMP induced host innate immunity", "down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity", "suppression of PAMP induced host innate immunity", "down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity", "suppression of MAMP-induced host innate immunity", "suppression of general elicitor-induced host innate immunity", "negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immune response", "suppression of general elicitor induced host innate immunity"], "types": ["T040"], "canonical_name": "suppression by symbiont of microbe-associated molecular pattern-induced host innate immune response"}
{"concept_id": "C2259749", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity"}
{"concept_id": "C2259750", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of host inflammatory response"}
{"concept_id": "C2259751", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host inflammatory response"}
{"concept_id": "C2259754", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host inflammatory response"}
{"concept_id": "C2259756", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host defense response"}
{"concept_id": "C2259758", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host programmed cell death"}
{"concept_id": "C2259761", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of host programmed cell death"}
{"concept_id": "C2259763", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host programmed cell death"}
{"concept_id": "C2259765", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host enzyme activity"}
{"concept_id": "C2259771", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of entry into host cell via phagocytosis"}
{"concept_id": "C2259773", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host jasmonic acid-mediated defense response"}
{"concept_id": "C2259781", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway"}
{"concept_id": "C2259782", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway"}
{"concept_id": "C2259784", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C2259785", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C2259787", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of host salicylic acid-mediated defense response"}
{"concept_id": "C2259788", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host salicylic acid-mediated defense response"}
{"concept_id": "C2259790", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of host jasmonic acid-mediated defense response"}
{"concept_id": "C2259791", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host jasmonic acid-mediated defense response"}
{"concept_id": "C2259793", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of host ethylene-mediated defense response"}
{"concept_id": "C2259794", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host ethylene-mediated defense response"}
{"concept_id": "C2259797", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway"}
{"concept_id": "C2259798", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway"}
{"concept_id": "C2259799", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway"}
{"concept_id": "C2259802", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host cell-mediated immune response"}
{"concept_id": "C2259804", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host T-cell mediated immune response"}
{"concept_id": "C2259806", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host B-cell mediated immune response"}
{"concept_id": "C2259809", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of nutrient release from host"}
{"concept_id": "C2259810", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of nutrient release from host"}
{"concept_id": "C2259812", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of defense-related host calcium-dependent protein kinase pathway"}
{"concept_id": "C2259813", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway"}
{"concept_id": "C2259821", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of host apoptosis"}
{"concept_id": "C2259822", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host apoptosis"}
{"concept_id": "C2259834", "aliases": [], "types": ["T044"], "canonical_name": "2,3-oxidosqualene sterol cyclase activity"}
{"concept_id": "C2259838", "aliases": [], "types": ["T044"], "canonical_name": "squalene epoxidase-cyclase activity"}
{"concept_id": "C2259841", "aliases": [], "types": ["T044"], "canonical_name": "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)"}
{"concept_id": "C2259842", "aliases": [], "types": ["T044"], "canonical_name": "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity"}
{"concept_id": "C2259843", "aliases": [], "types": ["T044"], "canonical_name": "C-3 sterol dehydrogenase (C-4 decarboxylase) activity"}
{"concept_id": "C2259844", "aliases": [], "types": ["T044"], "canonical_name": "C-3 sterol dehydrogenase activity"}
{"concept_id": "C2259845", "aliases": [], "types": ["T044"], "canonical_name": "sterol 4alpha-carboxylic decarboxylase activity"}
{"concept_id": "C2259846", "aliases": [], "types": ["T044"], "canonical_name": "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)"}
{"concept_id": "C2259858", "aliases": [], "types": ["T043"], "canonical_name": "cellular bud site selection", "definition": "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae. [GOC:mah]"}
{"concept_id": "C2259861", "aliases": [], "types": ["T044"], "canonical_name": "type III PIP kinase activity"}
{"concept_id": "C2259869", "aliases": [], "types": ["T045"], "canonical_name": "3' to 5' mRNA deadenylation"}
{"concept_id": "C2259870", "aliases": [], "types": ["T045"], "canonical_name": "mRNA deadenylation"}
{"concept_id": "C2259878", "aliases": [], "types": ["T044"], "canonical_name": "spermine transmembrane transporter activity", "definition": "Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. [GOC:ai]"}
{"concept_id": "C2259880", "aliases": [], "types": ["T044"], "canonical_name": "polyphosphatase activity"}
{"concept_id": "C2259881", "aliases": [], "types": ["T044"], "canonical_name": "polyphosphate depolymerase activity"}
{"concept_id": "C2259885", "aliases": [], "types": ["T044"], "canonical_name": "diphosphopyridine nucleotide pyrophosphorylase activity"}
{"concept_id": "C2259887", "aliases": [], "types": ["T044"], "canonical_name": "nicotinamide adenine dinucleotide pyrophosphorylase activity"}
{"concept_id": "C2259888", "aliases": ["nicotinamide mononucleotide adenylyltransferase activity", "NMNAT activity"], "types": ["T044"], "canonical_name": "NMN adenylyltransferase activity"}
{"concept_id": "C2259896", "aliases": ["vacuole, cell cycle-independent morphology"], "types": ["T026"], "canonical_name": "plant-type vacuole", "definition": "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. [GOC:mtg_sensu, ISBN:0815316208]"}
{"concept_id": "C2259897", "aliases": ["lumen of vacuole with cell cycle-correlated morphology"], "types": ["T026"], "canonical_name": "fungal-type vacuole lumen", "definition": "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae. [GOC:krc, GOC:mtg_sensu]"}
{"concept_id": "C2259915", "aliases": [], "types": ["T044"], "canonical_name": "galactosylceramidase I"}
{"concept_id": "C2259920", "aliases": [], "types": ["T044"], "canonical_name": "lactosylceramidase I"}
{"concept_id": "C2259923", "aliases": [], "types": ["T044"], "canonical_name": "geranyl transferase I"}
{"concept_id": "C2259925", "aliases": [], "types": ["T044"], "canonical_name": "1,3-beta-glucan glucohydrolase activity"}
{"concept_id": "C2259926", "aliases": ["exo-beta-(1->3)-D-glucanase activity", "exo (1->3)-beta-glucanase activity", "exo-1,3-beta-D-glucanase activity", "exo-beta-1,3-glucanase activity", "beta-1,3-glucan exo-hydrolase activity", "exo-beta-1,3-D-glucanase activity", "exo-1,3-beta-glucanase activity", "exo-beta-(1->3)-glucanohydrolase activity", "exo-1,3-beta-glucosidase activity"], "types": ["T044"], "canonical_name": "glucan exo-1,3-beta-glucosidase activity", "definition": "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose. [EC:3.2.1.58]"}
{"concept_id": "C2259937", "aliases": ["lysosomal alpha-glucosidase activity"], "types": ["T044"], "canonical_name": "lysosomal alpha-glucosidase activity"}
{"concept_id": "C2259945", "aliases": [], "types": ["T044"], "canonical_name": "lactonase activity"}
{"concept_id": "C2259950", "aliases": [], "types": ["T044"], "canonical_name": "glucosaminephosphate isomerase"}
{"concept_id": "C2259967", "aliases": [], "types": ["T044"], "canonical_name": "hexose monophosphate isomerase activity"}
{"concept_id": "C2259969", "aliases": [], "types": ["T044"], "canonical_name": "oxoisomerase activity"}
{"concept_id": "C2259972", "aliases": ["phosphohexoisomerase activity"], "types": ["T044"], "canonical_name": "phosphohexoisomerase activity"}
{"concept_id": "C2259973", "aliases": ["phosphohexomutase activity"], "types": ["T044"], "canonical_name": "phosphohexomutase activity"}
{"concept_id": "C2259974", "aliases": [], "types": ["T044"], "canonical_name": "phosphohexose isomerase activity"}
{"concept_id": "C2259975", "aliases": [], "types": ["T044"], "canonical_name": "phosphosaccharomutase activity"}
{"concept_id": "C2260009", "aliases": ["glutamic acid dehydrogenase"], "types": ["T044"], "canonical_name": "glutamic acid dehydrogenase"}
{"concept_id": "C2260010", "aliases": ["glutamic dehydrogenase activity"], "types": ["T044"], "canonical_name": "glutamic dehydrogenase activity"}
{"concept_id": "C2260011", "aliases": ["L-glutamate dehydrogenase"], "types": ["T044"], "canonical_name": "L-glutamate dehydrogenase"}
{"concept_id": "C2260031", "aliases": ["L-glutamate synthetase activity"], "types": ["T044"], "canonical_name": "L-glutamate synthetase activity"}
{"concept_id": "C2260046", "aliases": ["acetylornithinase activity"], "types": ["T044"], "canonical_name": "acetylornithinase activity"}
{"concept_id": "C2260050", "aliases": [], "types": ["T044"], "canonical_name": "N-acetyl-L-glutamate synthetase activity"}
{"concept_id": "C2260051", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylglutamate synthetase activity"}
{"concept_id": "C2260055", "aliases": [], "types": ["T044"], "canonical_name": "glutaminase I"}
{"concept_id": "C2260086", "aliases": ["phosphoglyceraldehyde dehydrogenase activity", "glyceraldehyde-3-P-dehydrogenase activity", "3-phosphoglyceraldehyde dehydrogenase activity", "glyceraldehyde phosphate dehydrogenase (NAD)", "NAD-dependent glyceraldehyde phosphate dehydrogenase activity", "GAPDH activity", "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)", "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity", "NADH-glyceraldehyde phosphate dehydrogenase activity", "dehydrogenase, glyceraldehyde phosphate"], "types": ["T044"], "canonical_name": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "definition": "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. [EC:1.2.1.12]"}
{"concept_id": "C2260090", "aliases": ["triosephosphate dehydrogenase activity"], "types": ["T044"], "canonical_name": "triosephosphate dehydrogenase activity"}
{"concept_id": "C2260101", "aliases": [], "types": ["T044"], "canonical_name": "glycerol 1-phosphate dehydrogenase activity"}
{"concept_id": "C2260104", "aliases": [], "types": ["T044"], "canonical_name": "hydroglycerophosphate dehydrogenase activity"}
{"concept_id": "C2260105", "aliases": [], "types": ["T044"], "canonical_name": "L-alpha-glycerol phosphate dehydrogenase activity"}
{"concept_id": "C2260106", "aliases": [], "types": ["T044"], "canonical_name": "L-alpha-glycerophosphate dehydrogenase activity"}
{"concept_id": "C2260107", "aliases": [], "types": ["T044"], "canonical_name": "L-glycerol phosphate dehydrogenase activity"}
{"concept_id": "C2260111", "aliases": ["NAD-linked glycerol 3-phosphate dehydrogenase activity", "alpha-glycerophosphate dehydrogenase (NAD) activity", "NAD-dependent glycerol-3-phosphate dehydrogenase activity", "glycerol phosphate dehydrogenase (NAD) activity", "glycerophosphate dehydrogenase (NAD) activity", "alpha-glycerol phosphate dehydrogenase (NAD) activity", "NAD-dependent glycerol phosphate dehydrogenase activity", "NAD-alpha-glycerophosphate dehydrogenase activity", "glycerol-3-phosphate dehydrogenase (NAD) activity", "NAD-L-glycerol-3-phosphate dehydrogenase activity"], "types": ["T044"], "canonical_name": "glycerol-3-phosphate dehydrogenase [NAD+] activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. [EC:1.1.1.8, RHEA:11092]"}
{"concept_id": "C2260113", "aliases": [], "types": ["T044"], "canonical_name": "NADH-dihydroxyacetone phosphate reductase activity"}
{"concept_id": "C2260171", "aliases": [], "types": ["T044"], "canonical_name": "GDP-mannose-oligosaccharide-lipid mannosyltransferase II"}
{"concept_id": "C2260177", "aliases": [], "types": ["T044"], "canonical_name": "myristoylating enzymes"}
{"concept_id": "C2260189", "aliases": [], "types": ["T044"], "canonical_name": "histo-blood group A acetylgalactosaminyltransferase activity"}
{"concept_id": "C2260191", "aliases": [], "types": ["T044"], "canonical_name": "histo-blood group A transferase activity"}
{"concept_id": "C2260195", "aliases": [], "types": ["T044"], "canonical_name": "[blood group substance] alpha-galactosyltransferase activity"}
{"concept_id": "C2260196", "aliases": [], "types": ["T044"], "canonical_name": "B transferase activity"}
{"concept_id": "C2260197", "aliases": [], "types": ["T044"], "canonical_name": "blood-group substance B-dependent galactosyltransferase activity"}
{"concept_id": "C2260198", "aliases": [], "types": ["T044"], "canonical_name": "blood-group substance beta-dependent galactosyltransferase activity"}
{"concept_id": "C2260200", "aliases": [], "types": ["T044"], "canonical_name": "histo-blood group B transferase activity"}
{"concept_id": "C2260202", "aliases": [], "types": ["T044"], "canonical_name": "histo-blood substance beta-dependent galactosyltransferase activity"}
{"concept_id": "C2260215", "aliases": [], "types": ["T044"], "canonical_name": "deoxyguanylate kinase activity"}
{"concept_id": "C2260220", "aliases": [], "types": ["T044"], "canonical_name": "ORP33 proteins"}
{"concept_id": "C2260229", "aliases": [], "types": ["T044"], "canonical_name": "hexokinase type I activity"}
{"concept_id": "C2260230", "aliases": [], "types": ["T044"], "canonical_name": "hexokinase type II activity"}
{"concept_id": "C2260231", "aliases": [], "types": ["T044"], "canonical_name": "hexokinase type III activity"}
{"concept_id": "C2260233", "aliases": [], "types": ["T044"], "canonical_name": "histidase activity"}
{"concept_id": "C2260234", "aliases": [], "types": ["T044"], "canonical_name": "histidinase activity"}
{"concept_id": "C2260235", "aliases": [], "types": ["T044"], "canonical_name": "histidine alpha-deaminase activity"}
{"concept_id": "C2260255", "aliases": [], "types": ["T045"], "canonical_name": "nucleosome-histone acetyltransferase activity"}
{"concept_id": "C2260257", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome c synthase activity"}
{"concept_id": "C2260261", "aliases": [], "types": ["T044"], "canonical_name": "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]"}
{"concept_id": "C2260302", "aliases": [], "types": ["T044"], "canonical_name": "uroporphyrinogen I synthase activity"}
{"concept_id": "C2260303", "aliases": [], "types": ["T044"], "canonical_name": "uroporphyrinogen I synthetase activity"}
{"concept_id": "C2260309", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-3-methylglutaryl CoA cleaving enzyme"}
{"concept_id": "C2260314", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethylglutaryl coenzyme A-cleaving enzyme"}
{"concept_id": "C2260324", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethylglutaryl coenzyme A-condensing enzyme"}
{"concept_id": "C2260326", "aliases": ["6-hydroxypurine phosphoribosyltransferase activity"], "types": ["T044"], "canonical_name": "6-hydroxypurine phosphoribosyltransferase activity"}
{"concept_id": "C2260327", "aliases": ["6-mercaptopurine phosphoribosyltransferase activity"], "types": ["T044"], "canonical_name": "6-mercaptopurine phosphoribosyltransferase activity"}
{"concept_id": "C2260329", "aliases": ["guanosine 5'-phosphate pyrophosphorylase activity", "guanosine phosphoribosyltransferase activity", "guanylate pyrophosphorylase activity", "guanylic pyrophosphorylase activity", "GMP pyrophosphorylase activity", "GPRT"], "types": ["T044"], "canonical_name": "guanine phosphoribosyltransferase activity", "definition": "Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.8, GOC:curators]"}
{"concept_id": "C2260330", "aliases": ["hypoxanthine-guanine phosphoribosyltransferase activity", "guanine-hypoxanthine phosphoribosyltransferase activity"], "types": ["T044"], "canonical_name": "guanine-hypoxanthine phosphoribosyltransferase activity"}
{"concept_id": "C2260344", "aliases": ["purine-6-thiol phosphoribosyltransferase activity"], "types": ["T044"], "canonical_name": "purine-6-thiol phosphoribosyltransferase activity"}
{"concept_id": "C2260357", "aliases": [], "types": ["T044"], "canonical_name": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]"}
{"concept_id": "C2260359", "aliases": [], "types": ["T044"], "canonical_name": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]"}
{"concept_id": "C2260367", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol 4-kinase activity"}
{"concept_id": "C2260368", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol kinase (phosphorylating) activity"}
{"concept_id": "C2260369", "aliases": ["phosphatidylinositol kinase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol kinase activity", "definition": "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. [GOC:ai]"}
{"concept_id": "C2260371", "aliases": [], "types": ["T044"], "canonical_name": "PI kinase activity"}
{"concept_id": "C2260372", "aliases": [], "types": ["T044"], "canonical_name": "PI4K-alpha activity"}
{"concept_id": "C2260373", "aliases": [], "types": ["T044"], "canonical_name": "PtdIns-4-kinase activity"}
{"concept_id": "C2260374", "aliases": [], "types": ["T044"], "canonical_name": "type II phosphatidylinositol kinase activity"}
{"concept_id": "C2260377", "aliases": ["monophosphatidylinositol phosphodiesterase activity"], "types": ["T044"], "canonical_name": "monophosphatidylinositol phosphodiesterase activity"}
{"concept_id": "C2260381", "aliases": [], "types": ["T044"], "canonical_name": "triphosphoinositide phosphodiesterase activity"}
{"concept_id": "C2260392", "aliases": ["phosphatidylinositol 4,5-bisphosphate phosphatase activity", "PI(4,5)P2 5-phosphatase activity", "PtdIns(4,5)P2 5-phosphatase activity", "PtdIns(4,5)P(2) 5-phosphatase activity", "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. [EC:3.1.3.36, RHEA:22764]"}
{"concept_id": "C2260393", "aliases": ["inositol triphosphate 5-phosphomonoesterase activity"], "types": ["T044"], "canonical_name": "inositol triphosphate 5-phosphomonoesterase activity"}
{"concept_id": "C2260398", "aliases": ["triphosphoinositide phosphatase activity", "triphosphoinositide phosphomonoesterase activity"], "types": ["T044"], "canonical_name": "triphosphoinositide phosphatase activity"}
{"concept_id": "C2260400", "aliases": ["type II inositol polyphosphate 5-phosphatase activity"], "types": ["T044"], "canonical_name": "type II inositol polyphosphate 5-phosphatase activity"}
{"concept_id": "C2260401", "aliases": [], "types": ["T044"], "canonical_name": "type II inositol-1,4,5-trisphosphate 5-phosphatase activity"}
{"concept_id": "C2260405", "aliases": ["inositol-1,4,5-trisphosphate 5-phosphatase activity", "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity", "D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity", "5PTase activity", "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity", "Ins(1,4,5)P(3) 5-phosphatase activity", "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity", "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity", "Ins(1,4,5)P3 5-phosphatase activity"], "types": ["T044"], "canonical_name": "inositol-1,4,5-trisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. [EC:3.1.3.56, RHEA:19797]"}
{"concept_id": "C2260409", "aliases": ["inosine triphosphatase activity"], "types": ["T044"], "canonical_name": "inosine triphosphatase activity"}
{"concept_id": "C2260410", "aliases": ["inositol phosphate 5-phosphomonoesterase activity"], "types": ["T044"], "canonical_name": "inositol phosphate 5-phosphomonoesterase activity"}
{"concept_id": "C2260413", "aliases": ["InsP3/Ins(1,3,4,5)P4 5-phosphatase activity"], "types": ["T044"], "canonical_name": "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity"}
{"concept_id": "C2260414", "aliases": ["L-myo-inositol 1,4,5-trisphosphate-monoesterase activity"], "types": ["T044"], "canonical_name": "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity"}
{"concept_id": "C2260416", "aliases": ["type I inositol-polyphosphate phosphatase activity"], "types": ["T044"], "canonical_name": "type I inositol-polyphosphate phosphatase activity"}
{"concept_id": "C2260417", "aliases": [], "types": ["T044"], "canonical_name": "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity"}
{"concept_id": "C2260418", "aliases": [], "types": ["T044"], "canonical_name": "inositol tetrakisphosphate phosphomonoesterase activity"}
{"concept_id": "C2260422", "aliases": [], "types": ["T044"], "canonical_name": "iodinase activity"}
{"concept_id": "C2260426", "aliases": [], "types": ["T044"], "canonical_name": "thyroperoxidase activity"}
{"concept_id": "C2260427", "aliases": ["thyroid peroxidase activity"], "types": ["T044"], "canonical_name": "TPO activity"}
{"concept_id": "C2260441", "aliases": [], "types": ["T044"], "canonical_name": "dual-cofactor-specific isocitrate dehydrogenase activity"}
{"concept_id": "C2260467", "aliases": [], "types": ["T044"], "canonical_name": "hepatic fructokinase activity"}
{"concept_id": "C2260489", "aliases": ["lactic acid dehydrogenase activity"], "types": ["T044"], "canonical_name": "lactic acid dehydrogenase activity"}
{"concept_id": "C2260493", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome b2 (flavin-free derivative of flavocytochrome b2)"}
{"concept_id": "C2260505", "aliases": [], "types": ["T044"], "canonical_name": "glyoxylase I"}
{"concept_id": "C2260520", "aliases": [], "types": ["T044"], "canonical_name": "clearing factor lipase activity"}
{"concept_id": "C2260545", "aliases": [], "types": ["T044"], "canonical_name": "pristanoyl-CoA synthetase"}
{"concept_id": "C2260546", "aliases": [], "types": ["T044"], "canonical_name": "stearoyl-CoA synthetase"}
{"concept_id": "C2260547", "aliases": [], "types": ["T044"], "canonical_name": "thiokinase"}
{"concept_id": "C2260558", "aliases": [], "types": ["T044"], "canonical_name": "NADP-linked decarboxylating malic enzyme"}
{"concept_id": "C2260561", "aliases": [], "types": ["T044"], "canonical_name": "NADP-specific malic enzyme"}
{"concept_id": "C2260567", "aliases": [], "types": ["T044"], "canonical_name": "malate condensing enzyme activity"}
{"concept_id": "C2260570", "aliases": [], "types": ["T044"], "canonical_name": "malic-condensing enzyme activity"}
{"concept_id": "C2260571", "aliases": ["GDP-mannose pyrophosphorylase activity"], "types": ["T044"], "canonical_name": "GDP-mannose pyrophosphorylase activity"}
{"concept_id": "C2260577", "aliases": [], "types": ["T044"], "canonical_name": "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)"}
{"concept_id": "C2260590", "aliases": [], "types": ["T044"], "canonical_name": "methionine-activating enzyme"}
{"concept_id": "C2260597", "aliases": [], "types": ["T045"], "canonical_name": "methionyl-transfer ribonucleate methyltransferase activity"}
{"concept_id": "C2260604", "aliases": ["cyclopropane synthetase activity"], "types": ["T044"], "canonical_name": "cyclopropane synthetase activity"}
{"concept_id": "C2260606", "aliases": ["unsaturated-phospholipid methyltransferase activity"], "types": ["T044"], "canonical_name": "unsaturated-phospholipid methyltransferase activity"}
{"concept_id": "C2260617", "aliases": [], "types": ["T045"], "canonical_name": "mRNA capping enzyme activity"}
{"concept_id": "C2260618", "aliases": [], "types": ["T045"], "canonical_name": "protein lambda2"}
{"concept_id": "C2260623", "aliases": ["5,10-methylene-THF dehydrogenase activity", "N5,N10-methylenetetrahydrofolate dehydrogenase activity"], "types": ["T044"], "canonical_name": "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+. [EC:1.5.1.15]"}
{"concept_id": "C2260629", "aliases": [], "types": ["T044"], "canonical_name": "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"}
{"concept_id": "C2260630", "aliases": [], "types": ["T044"], "canonical_name": "5,10-methylenetetrahydrofolic acid reductase activity"}
{"concept_id": "C2260637", "aliases": [], "types": ["T044"], "canonical_name": "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity"}
{"concept_id": "C2260639", "aliases": [], "types": ["T044"], "canonical_name": "methylenetetrahydrofolate reductase [NAD(P)H]"}
{"concept_id": "C2260640", "aliases": [], "types": ["T044"], "canonical_name": "methylenetetrahydrofolate reductase activity"}
{"concept_id": "C2260641", "aliases": ["methylenetetrahydrofolic acid reductase activity"], "types": ["T044"], "canonical_name": "MTHFR activity"}
{"concept_id": "C2260642", "aliases": [], "types": ["T044"], "canonical_name": "N(5),N(10)-methylenetetrahydrofolate reductase activity"}
{"concept_id": "C2260643", "aliases": [], "types": ["T044"], "canonical_name": "N(5,10)-methylenetetrahydrofolate reductase activity"}
{"concept_id": "C2260677", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxylase-25-hydroxyvitamin D3 activity"}
{"concept_id": "C2260683", "aliases": [], "types": ["T044"], "canonical_name": "FAD-containing monooxygenase activity"}
{"concept_id": "C2260684", "aliases": [], "types": ["T044"], "canonical_name": "flavin mixed function oxidase activity"}
{"concept_id": "C2260685", "aliases": [], "types": ["T044"], "canonical_name": "flavin monooxygenase activity"}
{"concept_id": "C2260686", "aliases": [], "types": ["T044"], "canonical_name": "FMO activity"}
{"concept_id": "C2260687", "aliases": [], "types": ["T044"], "canonical_name": "mixed-function amine oxidase activity"}
{"concept_id": "C2260688", "aliases": [], "types": ["T044"], "canonical_name": "Ziegler's enzyme"}
{"concept_id": "C2260696", "aliases": [], "types": ["T044"], "canonical_name": "MDBH (membrane-associated dopamine beta-monooxygenase)"}
{"concept_id": "C2260699", "aliases": [], "types": ["T044"], "canonical_name": "SDBH (soluble dopamine beta-monooxygenase)"}
{"concept_id": "C2260706", "aliases": [], "types": ["T044"], "canonical_name": "chlorogenic acid oxidase activity"}
{"concept_id": "C2260707", "aliases": [], "types": ["T044"], "canonical_name": "chlorogenic oxidase activity"}
{"concept_id": "C2260708", "aliases": [], "types": ["T044"], "canonical_name": "cresolase activity"}
{"concept_id": "C2260717", "aliases": [], "types": ["T044"], "canonical_name": "o-diphenol oxidase activity"}
{"concept_id": "C2260718", "aliases": [], "types": ["T044"], "canonical_name": "o-diphenol:O2 oxidoreductase activity"}
{"concept_id": "C2260723", "aliases": [], "types": ["T044"], "canonical_name": "peptide alpha-amidating enzyme"}
{"concept_id": "C2260740", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome p450 XIB1 activity"}
{"concept_id": "C2260745", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P-450 (P-45017alpha,lyase)"}
{"concept_id": "C2260746", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome p450 XVIIA1 activity"}
{"concept_id": "C2260747", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P45017alpha"}
{"concept_id": "C2260751", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome p450 XXIA1 activity"}
{"concept_id": "C2260766", "aliases": [], "types": ["T044"], "canonical_name": "sialyltransferase 3"}
{"concept_id": "C2260783", "aliases": [], "types": ["T044"], "canonical_name": "endothelium-derived relaxation factor-forming enzyme activity"}
{"concept_id": "C2260784", "aliases": [], "types": ["T044"], "canonical_name": "endothelium-derived relaxing factor synthase activity"}
{"concept_id": "C2260790", "aliases": [], "types": ["T045"], "canonical_name": "endoribonuclease I"}
{"concept_id": "C2260791", "aliases": [], "types": ["T045"], "canonical_name": "gene S glycoproteins"}
{"concept_id": "C2260792", "aliases": [], "types": ["T045"], "canonical_name": "gene S locus-specific glycoproteins"}
{"concept_id": "C2260797", "aliases": [], "types": ["T045"], "canonical_name": "RNase activity"}
{"concept_id": "C2260800", "aliases": [], "types": ["T045"], "canonical_name": "SLSG glycoproteins"}
{"concept_id": "C2260801", "aliases": [], "types": ["T045"], "canonical_name": "endoribonuclease H"}
{"concept_id": "C2260802", "aliases": [], "types": ["T045"], "canonical_name": "endoribonuclease H (calf thymus)"}
{"concept_id": "C2260803", "aliases": [], "types": ["T045"], "canonical_name": "endoribonuclease0 H activity"}
{"concept_id": "C2260811", "aliases": [], "types": ["T045"], "canonical_name": "5'-exonuclease activity"}
{"concept_id": "C2260812", "aliases": ["5'-nucleotide phosphodiesterase activity", "5'NPDE activity"], "types": ["T045"], "canonical_name": "5'-NPDase activity"}
{"concept_id": "C2260813", "aliases": ["5'-phosphodiesterase activity", "5'-PDase activity"], "types": ["T045"], "canonical_name": "5'-PDE activity"}
{"concept_id": "C2260814", "aliases": [], "types": ["T045"], "canonical_name": "alkaline phosphodiesterase activity"}
{"concept_id": "C2260815", "aliases": ["exonuclease I activity"], "types": ["T045"], "canonical_name": "exonuclease I activity"}
{"concept_id": "C2260821", "aliases": ["pancreatic deoxyribonuclease"], "types": ["T045"], "canonical_name": "deoxyribonuclease (pancreatic)"}
{"concept_id": "C2260822", "aliases": [], "types": ["T045"], "canonical_name": "deoxyribonuclease A"}
{"concept_id": "C2260828", "aliases": [], "types": ["T045"], "canonical_name": "dornava"}
{"concept_id": "C2260829", "aliases": ["pancreatic dornase"], "types": ["T045"], "canonical_name": "dornavac"}
{"concept_id": "C2260830", "aliases": [], "types": ["T045"], "canonical_name": "endodeoxyribonuclease I"}
{"concept_id": "C2260831", "aliases": [], "types": ["T045"], "canonical_name": "Escherichia coli endonuclease I"}
{"concept_id": "C2260832", "aliases": [], "types": ["T045"], "canonical_name": "pancreatic DNase activity"}
{"concept_id": "C2260834", "aliases": [], "types": ["T045"], "canonical_name": "thymonuclease activity"}
{"concept_id": "C2260838", "aliases": [], "types": ["T045"], "canonical_name": "lysosomal DNase II activity"}
{"concept_id": "C2260839", "aliases": [], "types": ["T045"], "canonical_name": "pancreatic DNase II"}
{"concept_id": "C2260840", "aliases": [], "types": ["T045"], "canonical_name": "retroviral reverse transcriptase RNaseH"}
{"concept_id": "C2260841", "aliases": [], "types": ["T045"], "canonical_name": "2',3'-exoribonuclease activity"}
{"concept_id": "C2260862", "aliases": ["glycogenase activity"], "types": ["T044"], "canonical_name": "glycogenase activity"}
{"concept_id": "C2260863", "aliases": [], "types": ["T044"], "canonical_name": "taka-amylase A"}
{"concept_id": "C2260878", "aliases": [], "types": ["T044"], "canonical_name": "1,2-alpha-D-mannosidase activity"}
{"concept_id": "C2260883", "aliases": [], "types": ["T044"], "canonical_name": "p-nitrophenyl-alpha-mannosidase activity"}
{"concept_id": "C2260899", "aliases": [], "types": ["T044"], "canonical_name": "hexosaminidase A"}
{"concept_id": "C2260908", "aliases": [], "types": ["T044"], "canonical_name": "hydrolact"}
{"concept_id": "C2260936", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein processing mannosidase I"}
{"concept_id": "C2260938", "aliases": [], "types": ["T044"], "canonical_name": "ManI activity"}
{"concept_id": "C2260940", "aliases": [], "types": ["T044"], "canonical_name": "mannosidase 1A activity"}
{"concept_id": "C2260941", "aliases": [], "types": ["T044"], "canonical_name": "mannosidase 1B activity"}
{"concept_id": "C2260943", "aliases": [], "types": ["T044"], "canonical_name": "alpha-mannosidase II"}
{"concept_id": "C2260947", "aliases": ["mannosidase II activity"], "types": ["T044"], "canonical_name": "ManII activity"}
{"concept_id": "C2260951", "aliases": [], "types": ["T044"], "canonical_name": "processing A-glucosidase I activity"}
{"concept_id": "C2260957", "aliases": [], "types": ["T044"], "canonical_name": "isomaltase activity"}
{"concept_id": "C2260960", "aliases": [], "types": ["T044"], "canonical_name": "intestinal sucrase activity"}
{"concept_id": "C2260961", "aliases": [], "types": ["T044"], "canonical_name": "sucrase(invertase)"}
{"concept_id": "C2260976", "aliases": [], "types": ["T044"], "canonical_name": "oligomannosyltransferase activity"}
{"concept_id": "C2261072", "aliases": [], "types": ["T044"], "canonical_name": "pantoate-activating enzyme activity"}
{"concept_id": "C2261073", "aliases": [], "types": ["T044"], "canonical_name": "pantoic-activating enzyme activity"}
{"concept_id": "C2261092", "aliases": [], "types": ["T044"], "canonical_name": "amino-terminal amino acid-acetylating enzyme activity"}
{"concept_id": "C2261093", "aliases": [], "types": ["T044"], "canonical_name": "beta-endorphin acetyltransferase activity"}
{"concept_id": "C2261094", "aliases": [], "types": ["T044"], "canonical_name": "N(alpha)-acetyltransferase activity"}
{"concept_id": "C2261096", "aliases": [], "types": ["T044"], "canonical_name": "NAT activity"}
{"concept_id": "C2261097", "aliases": [], "types": ["T044"], "canonical_name": "peptide acetyltransferase activity"}
{"concept_id": "C2261107", "aliases": [], "types": ["T044"], "canonical_name": "extensin peroxidase"}
{"concept_id": "C2261108", "aliases": [], "types": ["T044"], "canonical_name": "guaiacol peroxidase"}
{"concept_id": "C2261109", "aliases": [], "types": ["T044"], "canonical_name": "heme peroxidase"}
{"concept_id": "C2261110", "aliases": [], "types": ["T044"], "canonical_name": "horseradish peroxidase (HRP)"}
{"concept_id": "C2261111", "aliases": [], "types": ["T044"], "canonical_name": "japanese radish peroxidase"}
{"concept_id": "C2261113", "aliases": [], "types": ["T044"], "canonical_name": "protoheme peroxidase"}
{"concept_id": "C2261114", "aliases": [], "types": ["T044"], "canonical_name": "pyrocatechol peroxidase"}
{"concept_id": "C2261115", "aliases": [], "types": ["T044"], "canonical_name": "scopoletin peroxidase"}
{"concept_id": "C2261116", "aliases": [], "types": ["T044"], "canonical_name": "thiocyanate peroxidase"}
{"concept_id": "C2261117", "aliases": [], "types": ["T044"], "canonical_name": "verdoperoxidase"}
{"concept_id": "C2261173", "aliases": ["phosphoenolpyruvic carboxykinase (GTP)", "phosphopyruvate (guanosine triphosphate) carboxykinase activity", "phosphoenolpyruvate carboxykinase (GTP) activity", "phosphopyruvate carboxylase (GTP)", "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)", "phosphoenolpyruvic carboxylase (GTP)", "GTP:oxaloacetate carboxy-lyase (transphosphorylating)"], "types": ["T044"], "definition": "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2. [EC:4.1.1.32]", "canonical_name": "phosphoenolpyruvate carboxylase (GTP)"}
{"concept_id": "C2261192", "aliases": [], "types": ["T044"], "canonical_name": "D- and L-HGA"}
{"concept_id": "C2261213", "aliases": [], "types": ["T044"], "canonical_name": "diphosphoglycomutase"}
{"concept_id": "C2261214", "aliases": [], "types": ["T044"], "canonical_name": "GriP mutase"}
{"concept_id": "C2261230", "aliases": [], "types": ["T044"], "canonical_name": "lysophopholipase L2"}
{"concept_id": "C2261233", "aliases": [], "types": ["T044"], "canonical_name": "lysophospholipase A1"}
{"concept_id": "C2261234", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidase B"}
{"concept_id": "C2261237", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidase activity"}
{"concept_id": "C2261241", "aliases": [], "types": ["T044"], "canonical_name": "alpha-toxin"}
{"concept_id": "C2261245", "aliases": [], "types": ["T044"], "canonical_name": "lecithinase C activity"}
{"concept_id": "C2261246", "aliases": [], "types": ["T044"], "canonical_name": "lipophosphodiesterase C"}
{"concept_id": "C2261248", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidase C"}
{"concept_id": "C2261264", "aliases": [], "types": ["T044"], "canonical_name": "14-3-2-protein"}
{"concept_id": "C2261272", "aliases": [], "types": ["T044"], "canonical_name": "nervous-system specific enolase"}
{"concept_id": "C2261286", "aliases": [], "types": ["T044"], "canonical_name": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]"}
{"concept_id": "C2261291", "aliases": [], "types": ["T044"], "canonical_name": "class II PurE"}
{"concept_id": "C2261300", "aliases": [], "types": ["T044"], "canonical_name": "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)"}
{"concept_id": "C2261342", "aliases": [], "types": ["T044"], "canonical_name": "alpha-glucan phosphorylase"}
{"concept_id": "C2261343", "aliases": [], "types": ["T044"], "canonical_name": "amylopectin phosphorylase"}
{"concept_id": "C2261344", "aliases": [], "types": ["T044"], "canonical_name": "amylophosphorylase activity"}
{"concept_id": "C2261345", "aliases": [], "types": ["T044"], "canonical_name": "glucan phosphorylase"}
{"concept_id": "C2261346", "aliases": [], "types": ["T044"], "canonical_name": "glucosan phosphorylase"}
{"concept_id": "C2261347", "aliases": [], "types": ["T044"], "canonical_name": "granulose phosphorylase"}
{"concept_id": "C2261348", "aliases": [], "types": ["T044"], "canonical_name": "muscle phosphorylase"}
{"concept_id": "C2261349", "aliases": [], "types": ["T044"], "canonical_name": "muscle phosphorylase a and b activity"}
{"concept_id": "C2261350", "aliases": [], "types": ["T044"], "canonical_name": "myophosphorylase"}
{"concept_id": "C2261352", "aliases": [], "types": ["T044"], "canonical_name": "potato phosphorylase"}
{"concept_id": "C2261353", "aliases": [], "types": ["T044"], "canonical_name": "starch phosphorylase"}
{"concept_id": "C2261364", "aliases": [], "types": ["T044"], "canonical_name": "pectin depolymerase activity"}
{"concept_id": "C2261367", "aliases": [], "types": ["T044"], "canonical_name": "pectinase activity"}
{"concept_id": "C2261384", "aliases": [], "types": ["T045"], "canonical_name": "RNA formation factors, PF1"}
{"concept_id": "C2261412", "aliases": ["proline hydroxylase activity"], "types": ["T044"], "canonical_name": "proline hydroxylase activity"}
{"concept_id": "C2261415", "aliases": ["proline,2-oxoglutarate 4-dioxygenase activity"], "types": ["T044"], "canonical_name": "proline,2-oxoglutarate 4-dioxygenase activity"}
{"concept_id": "C2261416", "aliases": ["prolyl hydroxylase activity"], "types": ["T044"], "canonical_name": "prolyl hydroxylase activity"}
{"concept_id": "C2261420", "aliases": [], "types": ["T044"], "canonical_name": "protocollagen hydroxylase activity"}
{"concept_id": "C2261428", "aliases": [], "types": ["T044"], "canonical_name": "CAAX farnesyltransferase activity"}
{"concept_id": "C2261430", "aliases": [], "types": ["T044"], "canonical_name": "protein geranylgeranyltransferase type I"}
{"concept_id": "C2261457", "aliases": [], "types": ["T044"], "canonical_name": "isoprenylcysteine carboxylmethyltransferase activity"}
{"concept_id": "C2261460", "aliases": ["farnesyl cysteine C-terminal methyltransferase activity", "protein S-farnesylcysteine C-terminal methyltransferase activity", "prenylcysteine carboxylmethyltransferase activity", "prenylcysteine methyltransferase activity", "prenylcysteine carboxyl methyltransferase activity", "prenylcysteine carboxymethyltransferase activity", "farnesylated protein C-terminal O-methyltransferase activity", "prenylated protein carboxyl methyltransferase activity", "protein-S-isoprenylcysteine O-methyltransferase activity", "S-farnesylcysteine methyltransferase activity", "prenylated protein methyltransferase activity", "protein C-terminal farnesylcysteine O-methyltransferase activity", "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity", "farnesyl-protein carboxymethyltransferase activity", "isoprenylated protein methyltransferase activity"], "types": ["T044"], "canonical_name": "protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. [EC:2.1.1.100]"}
{"concept_id": "C2261492", "aliases": [], "types": ["T044"], "canonical_name": "protein kinase (phosphorylating) activity"}
{"concept_id": "C2261493", "aliases": [], "types": ["T044"], "canonical_name": "protein kinase A activity"}
{"concept_id": "C2261495", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphokinase activity"}
{"concept_id": "C2261496", "aliases": ["protein serine kinase activity", "protein-serine kinase activity", "serine protein kinase activity"], "types": ["T044"], "canonical_name": "protein serine kinase activity", "definition": "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]"}
{"concept_id": "C2261503", "aliases": [], "types": ["T044"], "canonical_name": "serine kinase activity"}
{"concept_id": "C2261504", "aliases": [], "types": ["T044"], "canonical_name": "serine-specific protein kinase activity"}
{"concept_id": "C2261506", "aliases": [], "types": ["T044"], "canonical_name": "threonine-specific protein kinase activity"}
{"concept_id": "C2261536", "aliases": [], "types": ["T044"], "canonical_name": "smooth-muscle-myosin-light-chain kinase activity"}
{"concept_id": "C2261547", "aliases": [], "types": ["T044"], "canonical_name": "PKG 1alpha"}
{"concept_id": "C2261548", "aliases": [], "types": ["T044"], "canonical_name": "PKG 1beta"}
{"concept_id": "C2261551", "aliases": [], "types": ["T044"], "canonical_name": "cdc2 kinase activity"}
{"concept_id": "C2261556", "aliases": [], "types": ["T044"], "canonical_name": "cyclin D-cdk6 kinase activity"}
{"concept_id": "C2261557", "aliases": [], "types": ["T044"], "canonical_name": "cyclin D-dependent kinase activity"}
{"concept_id": "C2261558", "aliases": [], "types": ["T044"], "canonical_name": "cyclin E kinase activity"}
{"concept_id": "C2261559", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-A associated kinase activity"}
{"concept_id": "C2261560", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-dependent kinase 6 activity"}
{"concept_id": "C2261561", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-dependent kinase activity"}
{"concept_id": "C2261562", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-dependent kinase-2 activity"}
{"concept_id": "C2261563", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-dependent kinase-4 activity"}
{"concept_id": "C2261564", "aliases": [], "types": ["T044"], "canonical_name": "D-type cyclin kinase activity"}
{"concept_id": "C2261565", "aliases": [], "types": ["T044"], "canonical_name": "neuronal cdc2-like kinase activity"}
{"concept_id": "C2261568", "aliases": [], "types": ["T044"], "canonical_name": "cPKCalpha"}
{"concept_id": "C2261569", "aliases": [], "types": ["T044"], "canonical_name": "cPKCbeta"}
{"concept_id": "C2261570", "aliases": [], "types": ["T044"], "canonical_name": "cPKCgamma"}
{"concept_id": "C2261571", "aliases": [], "types": ["T044"], "canonical_name": "nPKCdelta"}
{"concept_id": "C2261572", "aliases": [], "types": ["T044"], "canonical_name": "nPKCepsilon"}
{"concept_id": "C2261573", "aliases": [], "types": ["T044"], "canonical_name": "nPKCeta"}
{"concept_id": "C2261574", "aliases": [], "types": ["T044"], "canonical_name": "nPKCtheta"}
{"concept_id": "C2261575", "aliases": [], "types": ["T044"], "canonical_name": "PKCalpha"}
{"concept_id": "C2261576", "aliases": [], "types": ["T044"], "canonical_name": "PKCbeta"}
{"concept_id": "C2261577", "aliases": [], "types": ["T044"], "canonical_name": "PKCdelta"}
{"concept_id": "C2261578", "aliases": [], "types": ["T044"], "canonical_name": "PKCepsilon"}
{"concept_id": "C2261579", "aliases": [], "types": ["T044"], "canonical_name": "PKCgamma"}
{"concept_id": "C2261580", "aliases": [], "types": ["T044"], "canonical_name": "PKCzeta"}
{"concept_id": "C2261581", "aliases": [], "types": ["T044"], "canonical_name": "protein kinase Cepsilon activity"}
{"concept_id": "C2261584", "aliases": [], "types": ["T044"], "canonical_name": "c-Jun N-terminal kinase activity"}
{"concept_id": "C2261585", "aliases": [], "types": ["T044"], "canonical_name": "JNK3alpha1"}
{"concept_id": "C2261587", "aliases": [], "types": ["T044"], "canonical_name": "extracellular signal-regulated kinase activity"}
{"concept_id": "C2261588", "aliases": [], "types": ["T044"], "canonical_name": "MAP kinase 2 activity"}
{"concept_id": "C2261589", "aliases": [], "types": ["T044"], "canonical_name": "MBP kinase I activity"}
{"concept_id": "C2261590", "aliases": [], "types": ["T044"], "canonical_name": "MBP kinase II activity"}
{"concept_id": "C2261593", "aliases": [], "types": ["T044"], "canonical_name": "myelin basic protein kinase activity"}
{"concept_id": "C2261599", "aliases": [], "types": ["T044"], "canonical_name": "MAP kinase kinase 4 activity"}
{"concept_id": "C2261600", "aliases": [], "types": ["T044"], "canonical_name": "MAP kinase kinase 7 activity"}
{"concept_id": "C2261601", "aliases": [], "types": ["T044"], "canonical_name": "MAP kinase or ERK kinase activity"}
{"concept_id": "C2261604", "aliases": [], "types": ["T044"], "canonical_name": "Mil/Raf"}
{"concept_id": "C2261606", "aliases": [], "types": ["T044"], "canonical_name": "MLK-like mitogen-activated protein triple kinase activity"}
{"concept_id": "C2261607", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [GOC:mah]", "canonical_name": "protein serine/threonine/tyrosine kinase activity"}
{"concept_id": "C2261612", "aliases": [], "types": ["T044"], "canonical_name": "ATP:protein-tyrosine O-phosphotransferase activity"}
{"concept_id": "C2261625", "aliases": [], "types": ["T044"], "canonical_name": "Bruton's tyrosine kinase activity"}
{"concept_id": "C2261626", "aliases": [], "types": ["T044"], "canonical_name": "cytoplasmic protein tyrosine kinase activity"}
{"concept_id": "C2261628", "aliases": [], "types": ["T044"], "canonical_name": "janus kinase 1 activity"}
{"concept_id": "C2261629", "aliases": [], "types": ["T044"], "canonical_name": "janus kinase 2 activity"}
{"concept_id": "C2261630", "aliases": [], "types": ["T044"], "canonical_name": "janus kinase 3 activity"}
{"concept_id": "C2261632", "aliases": [], "types": ["T044"], "canonical_name": "p60c-src protein tyrosine kinase activity"}
{"concept_id": "C2261644", "aliases": ["protein phosphatase-1 activity"], "types": ["T044"], "canonical_name": "protein phosphatase-1"}
{"concept_id": "C2261645", "aliases": ["protein phosphatase-2B activity"], "types": ["T044"], "canonical_name": "protein phosphatase-2B"}
{"concept_id": "C2261646", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase-2C activity"}
{"concept_id": "C2261656", "aliases": [], "types": ["T044"], "canonical_name": "phosphatase I"}
{"concept_id": "C2261658", "aliases": [], "types": ["T044"], "canonical_name": "phosphatase II"}
{"concept_id": "C2261659", "aliases": [], "types": ["T044"], "canonical_name": "phosphatase III"}
{"concept_id": "C2261678", "aliases": ["protoporphyrinogen-IX:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "oxygen-dependent protoporphyrinogen oxidase activity", "definition": "Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX. [EC:1.3.3.4, RHEA:25576]"}
{"concept_id": "C2261688", "aliases": [], "types": ["T044"], "canonical_name": "uracil hydrolyase activity"}
{"concept_id": "C2261689", "aliases": [], "types": ["T044"], "canonical_name": "inosine phosphorylase activity"}
{"concept_id": "C2261719", "aliases": [], "types": ["T044"], "canonical_name": "MtPDC (mitochondrial pyruvate dehydogenase complex) activity"}
{"concept_id": "C2261720", "aliases": [], "types": ["T044"], "canonical_name": "pyruvate dehydrogenase complex activity"}
{"concept_id": "C2261740", "aliases": [], "types": ["T044"], "canonical_name": "thioltransacetylase A activity"}
{"concept_id": "C2261741", "aliases": [], "types": ["T044"], "canonical_name": "transacetylase X activity"}
{"concept_id": "C2261746", "aliases": [], "types": ["T044"], "canonical_name": "retinene isomerase activity"}
{"concept_id": "C2261747", "aliases": [], "types": ["T044"], "canonical_name": "retinoid isomerase activity"}
{"concept_id": "C2261748", "aliases": ["all-trans-retinol dehydrogenase activity"], "types": ["T044"], "canonical_name": "all-trans retinol dehydrogenase activity"}
{"concept_id": "C2261750", "aliases": [], "types": ["T044"], "canonical_name": "retinene reductase activity"}
{"concept_id": "C2261751", "aliases": [], "types": ["T044"], "canonical_name": "retinol (vitamin A1) dehydrogenase activity"}
{"concept_id": "C2261754", "aliases": [], "types": ["T044"], "canonical_name": "heavy riboflavin synthase"}
{"concept_id": "C2261755", "aliases": [], "types": ["T044"], "canonical_name": "light riboflavin synthase"}
{"concept_id": "C2261756", "aliases": ["lumazine synthase activity"], "types": ["T044"], "canonical_name": "lumazine synthase activity"}
{"concept_id": "C2261767", "aliases": ["ribonucleotide reductase activity"], "types": ["T044"], "canonical_name": "ribonucleotide reductase activity"}
{"concept_id": "C2261825", "aliases": ["shikimate oxidoreductase activity", "5-dehydroshikimic reductase activity", "5-dehydroshikimate reductase activity", "shikimate:NADP(+) 5-oxidoreductase activity"], "types": ["T044"], "canonical_name": "shikimate 3-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. [EC:1.1.1.25]"}
{"concept_id": "C2261827", "aliases": ["dehydroshikimic reductase activity", "DHS reductase activity"], "types": ["T044"], "canonical_name": "dehydroshikimic reductase activity"}
{"concept_id": "C2261831", "aliases": [], "types": ["T044"], "canonical_name": "shikimate:NADP(+) oxidoreductase activity"}
{"concept_id": "C2261842", "aliases": ["acyl-CoA desaturase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O. [GOC:mah]", "canonical_name": "acyl-CoA desaturase"}
{"concept_id": "C2261843", "aliases": ["delta(9)-desaturase activity", "stearoyl-CoA desaturase activity"], "types": ["T044"], "canonical_name": "stearoyl-CoA 9-desaturase activity", "definition": "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O. [RHEA:19721]"}
{"concept_id": "C2261861", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol ester synthase activity"}
{"concept_id": "C2261862", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol esterase activity"}
{"concept_id": "C2261890", "aliases": [], "types": ["T044"], "canonical_name": "succinic thiokinase"}
{"concept_id": "C2261891", "aliases": [], "types": ["T044"], "canonical_name": "succinyl coenzyme A synthetase"}
{"concept_id": "C2261900", "aliases": ["succinyl semialdehyde dehydrogenase activity", "succinate-semialdehyde:NAD+ oxidoreductase activity", "succinate semialdehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "succinate-semialdehyde dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+. [RHEA:13217]"}
{"concept_id": "C2261901", "aliases": [], "types": ["T044"], "canonical_name": "succinic semialdehyde dehydrogenase activity"}
{"concept_id": "C2261914", "aliases": [], "types": ["T044"], "canonical_name": "sulfurylase activity"}
{"concept_id": "C2261927", "aliases": [], "types": ["T044"], "canonical_name": "Cu,Zn-SOD"}
{"concept_id": "C2261929", "aliases": [], "types": ["T044"], "canonical_name": "cuprein"}
{"concept_id": "C2261930", "aliases": [], "types": ["T044"], "canonical_name": "ferrisuperoxide dismutase activity"}
{"concept_id": "C2261931", "aliases": [], "types": ["T044"], "canonical_name": "hepatocuprein"}
{"concept_id": "C2261932", "aliases": [], "types": ["T044"], "canonical_name": "iron superoxide oxidoreductase"}
{"concept_id": "C2261933", "aliases": [], "types": ["T044"], "canonical_name": "superoxide dismutase I"}
{"concept_id": "C2261934", "aliases": [], "types": ["T044"], "canonical_name": "superoxide dismutase II"}
{"concept_id": "C2261955", "aliases": [], "types": ["T044"], "canonical_name": "rhodanese activity"}
{"concept_id": "C2261990", "aliases": [], "types": ["T044"], "canonical_name": "type I iodothyronine deiodinase activity"}
{"concept_id": "C2261991", "aliases": [], "types": ["T044"], "canonical_name": "type II iodothyronine deiodinase activity"}
{"concept_id": "C2261992", "aliases": ["dihydroxyacetonetransferase activity"], "types": ["T044"], "canonical_name": "dihydroxyacetone transferase activity"}
{"concept_id": "C2261993", "aliases": [], "types": ["T044"], "canonical_name": "glycerone transferase activity"}
{"concept_id": "C2261994", "aliases": ["sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity"], "types": ["T044"], "canonical_name": "transaldolase activity", "definition": "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. [PMID:7592346, RHEA:17053]"}
{"concept_id": "C2261997", "aliases": [], "types": ["T044"], "canonical_name": "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity"}
{"concept_id": "C2262001", "aliases": [], "types": ["T044"], "canonical_name": "amano AP"}
{"concept_id": "C2262002", "aliases": [], "types": ["T044"], "canonical_name": "amano B"}
{"concept_id": "C2262003", "aliases": ["amano CE"], "types": ["T044"], "canonical_name": "amano CES"}
{"concept_id": "C2262004", "aliases": [], "types": ["T044"], "canonical_name": "amano P"}
{"concept_id": "C2262005", "aliases": [], "types": ["T044"], "canonical_name": "amno N-AP"}
{"concept_id": "C2262008", "aliases": [], "types": ["T044"], "canonical_name": "capalase L"}
{"concept_id": "C2262010", "aliases": [], "types": ["T044"], "canonical_name": "heparin releasable hepatic lipase"}
{"concept_id": "C2262011", "aliases": [], "types": ["T044"], "canonical_name": "hepatic lipase"}
{"concept_id": "C2262012", "aliases": [], "types": ["T044"], "canonical_name": "hepatic monoacylglycerol acyltransferase"}
{"concept_id": "C2262013", "aliases": [], "types": ["T044"], "canonical_name": "lipazin"}
{"concept_id": "C2262014", "aliases": [], "types": ["T044"], "canonical_name": "liver lipase"}
{"concept_id": "C2262015", "aliases": [], "types": ["T044"], "canonical_name": "meito MY 30"}
{"concept_id": "C2262016", "aliases": [], "types": ["T044"], "canonical_name": "meito sangyo OF lipase"}
{"concept_id": "C2262017", "aliases": [], "types": ["T044"], "canonical_name": "post-heparin plasma protamine-resistant lipase"}
{"concept_id": "C2262018", "aliases": [], "types": ["T044"], "canonical_name": "salt-resistant post-heparin lipase"}
{"concept_id": "C2262019", "aliases": [], "types": ["T044"], "canonical_name": "steapsin"}
{"concept_id": "C2262020", "aliases": [], "types": ["T044"], "canonical_name": "takedo 1969-4-9"}
{"concept_id": "C2262024", "aliases": [], "types": ["T044"], "canonical_name": "tributyrase activity"}
{"concept_id": "C2262029", "aliases": ["glycerol ester hydrolase activity", "GEH", "PPL", "triacylglycerol lipase activity", "tributyrin esterase activity", "TAG activity", "tweenesterase activity", "tween hydrolase activity", "triacetinase activity", "tributyrinase activity", "triglyceride lipase activity", "butyrinase activity", "triacylglycerol acylhydrolase activity", "triglyceride hydrolase activity", "triacylglycerol ester hydrolase activity", "tweenase activity", "triolein hydrolase activity", "tween-hydrolyzing esterase activity", "cacordase activity", "triglyceridase activity", "GA 56"], "types": ["T044"], "definition": "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. [EC:3.1.1.3]", "canonical_name": "glycerol-ester hydrolase activity"}
{"concept_id": "C2262099", "aliases": [], "types": ["T045"], "canonical_name": "glutaminyl ribonucleic acid"}
{"concept_id": "C2262179", "aliases": [], "types": ["T045"], "canonical_name": "indolamine 2,3-dioxygenase activity"}
{"concept_id": "C2262184", "aliases": [], "types": ["T045"], "canonical_name": "tryptophan oxygenase activity"}
{"concept_id": "C2262185", "aliases": [], "types": ["T045"], "canonical_name": "tryptophan peroxidase activity"}
{"concept_id": "C2262186", "aliases": ["tryptophan pyrrolase activity"], "types": ["T044"], "canonical_name": "tryptophan pyrrolase activity"}
{"concept_id": "C2262188", "aliases": [], "types": ["T044"], "canonical_name": "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]"}
{"concept_id": "C2262197", "aliases": [], "types": ["T044"], "canonical_name": "glutamic phenylpyruvic aminotransferase activity"}
{"concept_id": "C2262198", "aliases": [], "types": ["T044"], "canonical_name": "glutamic-hydroxyphenylpyruvic transaminase activity"}
{"concept_id": "C2262199", "aliases": ["L-phenylalanine:alpha-ketoglutarate aminotransferase activity", "L-phenylalanine 2-oxoglutarate aminotransferase activity", "L-phenylalanine-2-oxoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "L-phenylalanine:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate. [GOC:pmn_curators, PMID:18394996]"}
{"concept_id": "C2262200", "aliases": ["L-tyrosine aminotransferase activity"], "types": ["T044"], "canonical_name": "L-tyrosine aminotransferase activity", "definition": "Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid. [GOC:mah]"}
{"concept_id": "C2262201", "aliases": [], "types": ["T044"], "canonical_name": "L-tyrosine:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate. [EC:2.6.1.5]"}
{"concept_id": "C2262202", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine aminotransferase activity"}
{"concept_id": "C2262203", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine transaminase activity"}
{"concept_id": "C2262204", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine-alpha-ketoglutarate transaminase activity"}
{"concept_id": "C2262205", "aliases": [], "types": ["T044"], "canonical_name": "phenylpyruvate transaminase activity"}
{"concept_id": "C2262206", "aliases": [], "types": ["T044"], "canonical_name": "phenylpyruvic acid transaminase activity"}
{"concept_id": "C2262208", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine-2-ketoglutarate aminotransferase activity"}
{"concept_id": "C2262209", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine-alpha-ketoglutarate aminotransferase activity"}
{"concept_id": "C2262210", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine-alpha-ketoglutarate transaminase activity"}
{"concept_id": "C2262224", "aliases": [], "types": ["T044"], "canonical_name": "uricase II activity"}
{"concept_id": "C2262238", "aliases": ["pyrimidine phosphorylase activity"], "types": ["T044"], "canonical_name": "pyrimidine phosphorylase activity"}
{"concept_id": "C2262268", "aliases": ["schardinger enzyme"], "types": ["T044"], "canonical_name": "schardinger enzyme"}
{"concept_id": "C2262278", "aliases": ["type I IFN receptor activity"], "types": ["T044"], "canonical_name": "type I interferon receptor activity", "definition": "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834]"}
{"concept_id": "C2262279", "aliases": [], "types": ["T044"], "canonical_name": "interferon-alpha receptor activity"}
{"concept_id": "C2262280", "aliases": [], "types": ["T044"], "canonical_name": "interferon-beta receptor activity"}
{"concept_id": "C2262281", "aliases": [], "types": ["T044"], "canonical_name": "interferon-delta receptor activity"}
{"concept_id": "C2262282", "aliases": [], "types": ["T044"], "canonical_name": "interferon-epsilon receptor activity"}
{"concept_id": "C2262283", "aliases": [], "types": ["T044"], "canonical_name": "interferon-kappa receptor activity"}
{"concept_id": "C2262284", "aliases": [], "types": ["T044"], "canonical_name": "interferon-omega receptor activity"}
{"concept_id": "C2262285", "aliases": [], "types": ["T044"], "canonical_name": "interferon-tau receptor activity"}
{"concept_id": "C2262286", "aliases": [], "types": ["T044"], "canonical_name": "interferon-zeta receptor activity"}
{"concept_id": "C2262289", "aliases": ["extracellular-glutamate-gated ion channel activity"], "types": ["T044"], "canonical_name": "extracellularly glutamate-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2262290", "aliases": [], "types": ["T044"], "canonical_name": "connexin"}
{"concept_id": "C2262295", "aliases": [], "types": ["T044"], "canonical_name": "cystic fibrosis transmembrane conductance regulator"}
{"concept_id": "C2262297", "aliases": [], "types": ["T044"], "canonical_name": "allantoin uptake transmembrane transporter activity"}
{"concept_id": "C2262298", "aliases": ["high affinity basic amino acid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity basic amino acid transmembrane transporter activity", "definition": "Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport]"}
{"concept_id": "C2262299", "aliases": ["high affinity arginine transmembrane transporter activity", "high-affinity arginine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity L-arginine transmembrane transporter activity", "definition": "Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport]"}
{"concept_id": "C2262300", "aliases": [], "types": ["T044"], "canonical_name": "L-histidine transmembrane transporter activity", "definition": "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2262301", "aliases": ["high affinity L-histidine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity L-histidine transmembrane transporter activity", "definition": "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport]"}
{"concept_id": "C2262302", "aliases": ["high affinity lysine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity lysine transmembrane transporter activity", "definition": "Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport]"}
{"concept_id": "C2262303", "aliases": [], "types": ["T044"], "canonical_name": "neutral L-amino acid secondary active transmembrane transporter activity", "definition": "Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]"}
{"concept_id": "C2262304", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity tryptophan transmembrane transporter activity", "definition": "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2262305", "aliases": [], "types": ["T044"], "canonical_name": "L-valine transmembrane transporter activity", "definition": "Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2262306", "aliases": [], "types": ["T044"], "canonical_name": "dicarboxylic acid transmembrane transporter activity", "definition": "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. [GOC:ai]"}
{"concept_id": "C2262307", "aliases": [], "types": ["T044"], "canonical_name": "L-glutamate transmembrane transporter activity", "definition": "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2262308", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity glutamate transmembrane transporter activity"}
{"concept_id": "C2262310", "aliases": [], "types": ["T044"], "canonical_name": "nucleotide-sugar transmembrane transporter activity", "definition": "Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]"}
{"concept_id": "C2262311", "aliases": [], "types": ["T044"], "canonical_name": "organic acid transmembrane transporter activity", "definition": "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. [ISBN:0198506732]"}
{"concept_id": "C2262313", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen:sugar transporter activity"}
{"concept_id": "C2262314", "aliases": [], "types": ["T044"], "canonical_name": "galactose transmembrane transporter activity", "definition": "Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2262315", "aliases": ["glucose:proton symporter activity", "transepithelial hydrogen:glucose symporter activity", "transepithelial hydrogen/glucose transporter activity", "hydrogen:glucose transporter activity", "transepithelial hydrogen:glucose transporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport]", "canonical_name": "hydrogen:glucose symporter activity"}
{"concept_id": "C2262316", "aliases": ["insulin-responsive hydrogen:glucose transporter activity", "insulin-responsive glucose:proton symporter activity", "transepithelial hydrogen/glucose transporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport]", "canonical_name": "insulin-responsive hydrogen:glucose symporter activity"}
{"concept_id": "C2262322", "aliases": [], "types": ["T044"], "canonical_name": "calcium-translocating P-type ATPase activity"}
{"concept_id": "C2262324", "aliases": [], "types": ["T044"], "canonical_name": "sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C2262331", "aliases": [], "types": ["T044"], "canonical_name": "pyruvate secondary active transmembrane transporter activity", "definition": "Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]"}
{"concept_id": "C2262332", "aliases": [], "types": ["T044"], "canonical_name": "R-SNARE activity"}
{"concept_id": "C2262334", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host innate immunity"}
{"concept_id": "C2262337", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host innate immunity"}
{"concept_id": "C2262365", "aliases": ["down-regulation by organism of defense response of other organism during symbiotic interaction", "downregulation by organism of defense response of other organism during symbiotic interaction"], "types": ["T040"], "canonical_name": "down regulation by organism of defense response of other organism during symbiotic interaction"}
{"concept_id": "C2262366", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by organism of defense response of other organism during symbiotic interaction"}
{"concept_id": "C2262419", "aliases": ["up regulation of phytoalexin metabolism", "upregulation of phytoalexin metabolism", "up-regulation of phytoalexin metabolism"], "types": ["T044"], "canonical_name": "positive regulation of phytoalexin metabolic process", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C2262420", "aliases": [], "types": ["T040"], "canonical_name": "activation of phytoalexin metabolism"}
{"concept_id": "C2262421", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of phytoalexin metabolism"}
{"concept_id": "C2262422", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of phytoalexin metabolism"}
{"concept_id": "C2262423", "aliases": [], "types": ["T040"], "canonical_name": "activation of phytoalexin biosynthesis"}
{"concept_id": "C2262424", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of phytoalexin biosynthesis"}
{"concept_id": "C2262425", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of phytoalexin biosynthesis"}
{"concept_id": "C2262433", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of host phytoalexin production"}
{"concept_id": "C2262434", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host phytoalexin production"}
{"concept_id": "C2262440", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of defense-related host nitric oxide production"}
{"concept_id": "C2262450", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of defense-related host reactive oxygen species production"}
{"concept_id": "C2262452", "aliases": ["downregulation by organism of entry into other organism during symbiotic interaction", "down-regulation by organism of entry into other organism during symbiotic interaction"], "types": ["T040"], "canonical_name": "down regulation by organism of entry into other organism during symbiotic interaction"}
{"concept_id": "C2262453", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by organism of entry into other organism during symbiotic interaction"}
{"concept_id": "C2262464", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of defense-related host calcium ion flux"}
{"concept_id": "C2262475", "aliases": [], "types": ["T043"], "canonical_name": "inhibition by host of symbiont enzyme activity"}
{"concept_id": "C2262534", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by host of symbiont programmed cell death"}
{"concept_id": "C2262572", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host defense response"}
{"concept_id": "C2262594", "aliases": [], "types": ["T040"], "canonical_name": "activation by host of nutrient release from symbiont"}
{"concept_id": "C2262595", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by host of nutrient release from symbiont"}
{"concept_id": "C2262622", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of induced systemic resistance in other organism involved in symbiotic interaction"}
{"concept_id": "C2262641", "aliases": [], "types": ["T044"], "canonical_name": "regulation of endopeptidase activity", "definition": "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. [GOC:ai, GOC:hjd]"}
{"concept_id": "C2262646", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of host immune response"}
{"concept_id": "C2262653", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host immune response"}
{"concept_id": "C2262659", "aliases": [], "types": ["T042"], "canonical_name": "heart myofibril assembly"}
{"concept_id": "C2262662", "aliases": [], "types": ["T043"], "canonical_name": "heart cell development"}
{"concept_id": "C2262665", "aliases": ["atrial heart muscle morphogenesis", "cardiac atrium muscle morphogenesis", "atrial myocardium morphogenesis"], "types": ["T042"], "canonical_name": "atrial cardiac muscle tissue morphogenesis", "definition": "The process in which the anatomical structure of cardiac atrium muscle is generated and organized. [GOC:devbiol]"}
{"concept_id": "C2262666", "aliases": ["ventricular heart muscle morphogenesis", "cardiac ventricle muscle morphogenesis"], "types": ["T042"], "canonical_name": "ventricular cardiac muscle tissue morphogenesis", "definition": "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. [GOC:devbiol]"}
{"concept_id": "C2262673", "aliases": ["heart muscle growth"], "types": ["T042"], "canonical_name": "cardiac muscle tissue growth", "definition": "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. [GOC:devbiol]"}
{"concept_id": "C2262676", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cardiac muscle fiber development"}
{"concept_id": "C2262677", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of heart muscle fiber development"}
{"concept_id": "C2262678", "aliases": [], "types": ["T039"], "canonical_name": "activation of cardiac muscle fiber development"}
{"concept_id": "C2262680", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of cardiac muscle fiber development"}
{"concept_id": "C2262683", "aliases": ["down regulation of cardiac muscle growth", "inhibition of cardiac muscle growth", "negative regulation of heart muscle growth", "down-regulation of cardiac muscle growth", "downregulation of cardiac muscle growth"], "types": ["T042"], "canonical_name": "negative regulation of cardiac muscle tissue growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. [GOC:vk]"}
{"concept_id": "C2262685", "aliases": ["upregulation of cardiac muscle growth", "positive regulation of heart muscle growth", "up regulation of cardiac muscle growth", "up-regulation of cardiac muscle growth", "stimulation of cardiac muscle growth", "activation of cardiac muscle growth"], "types": ["T042"], "canonical_name": "positive regulation of cardiac muscle tissue growth", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. [GOC:vk]"}
{"concept_id": "C2262689", "aliases": ["regulation of heart muscle development"], "types": ["T042"], "canonical_name": "regulation of cardiac muscle tissue development", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. [GOC:vk]"}
{"concept_id": "C2262690", "aliases": ["positive regulation of heart muscle development", "up-regulation of cardiac muscle development", "upregulation of cardiac muscle development", "activation of cardiac muscle development", "up regulation of cardiac muscle development", "stimulation of cardiac muscle development"], "types": ["T042"], "canonical_name": "positive regulation of cardiac muscle tissue development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. [GOC:vk]"}
{"concept_id": "C2262695", "aliases": ["downregulation of cardiac muscle development", "down regulation of cardiac muscle development", "inhibition of cardiac muscle development", "down-regulation of cardiac muscle development", "negative regulation of heart muscle development"], "types": ["T042"], "canonical_name": "negative regulation of cardiac muscle tissue development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. [GOC:vk]"}
{"concept_id": "C2262697", "aliases": [], "types": ["T026"], "canonical_name": "cortical microtubule", "definition": "Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol. [GOC:mtg_sensu]"}
{"concept_id": "C2262698", "aliases": ["nuclear DNA-directed RNA polymerase complex location"], "types": ["T026"], "canonical_name": "nuclear DNA-directed RNA polymerase complex", "definition": "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity. [GOC:mtg_sensu]"}
{"concept_id": "C2262703", "aliases": [], "types": ["T042"], "canonical_name": "Bolwig's organ development", "definition": "The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain. [GOC:mtg_sensu]"}
{"concept_id": "C2262704", "aliases": [], "types": ["T026"], "canonical_name": "plastid thylakoid membrane", "definition": "The lipid bilayer membrane of any thylakoid within a plastid. [GOC:jid, GOC:rph]"}
{"concept_id": "C2262705", "aliases": [], "types": ["T026"], "canonical_name": "virion membrane", "definition": "The lipid bilayer surrounding a virion. [GOC:jid, GOC:rph, PMID:213106]"}
{"concept_id": "C2262706", "aliases": ["recycling endosome", "ERC"], "types": ["T026"], "definition": "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]", "canonical_name": "endosomal recycling compartment"}
{"concept_id": "C2262707", "aliases": [], "types": ["T026"], "canonical_name": "recycling endosome membrane", "definition": "The lipid bilayer surrounding a recycling endosome. [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]"}
{"concept_id": "C2262708", "aliases": [], "types": ["T026"], "canonical_name": "trichocyst", "definition": "A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in net-like structures, to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft. [GOC:jid, GOC:rph, http://www.iscid.org/encyclopedia/, PMID:3667715]"}
{"concept_id": "C2262709", "aliases": [], "types": ["T026"], "canonical_name": "periplasmic flagellum", "definition": "Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella. [GOC:jid, GOC:rph, PMID:15175283, PMID:1624463]"}
{"concept_id": "C2262710", "aliases": ["cyclopentanol:NAD+ oxidoreductase activity", "cyclopentanol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "cyclopentanol dehydrogenase activity", "definition": "Catalysis of the reaction: cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH. [EC:1.1.1.163, RHEA:11728]"}
{"concept_id": "C2262711", "aliases": [], "types": ["T044"], "canonical_name": "5-valerolactone hydrolase activity", "definition": "Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate. [GOC:jid, GOC:mlg]"}
{"concept_id": "C2262712", "aliases": [], "types": ["T044"], "canonical_name": "5-oxovalerate dehydrogenase activity", "definition": "Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+. [GOC:jid, GOC:mlg]"}
{"concept_id": "C2262713", "aliases": [], "types": ["T026"], "canonical_name": "symplast", "definition": "The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata. [GOC:mtg_sensu]"}
{"concept_id": "C2262714", "aliases": [], "types": ["T043"], "canonical_name": "antipodal cell degeneration", "definition": "The process in which the antipodal cells undergo programmed cell death. [GOC:mtg_plant]"}
{"concept_id": "C2262715", "aliases": ["pollen development from the microspore"], "types": ["T042"], "canonical_name": "microgametogenesis", "definition": "The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure. [GOC:mtg_plant]"}
{"concept_id": "C2262716", "aliases": [], "types": ["T043"], "canonical_name": "generative cell mitosis", "definition": "The process in which the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells. [GOC:mtg_plant]"}
{"concept_id": "C2262717", "aliases": [], "types": ["T043"], "canonical_name": "anastral spindle assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins. [GOC:expert_rg, GOC:mtg_sensu, GOC:tb, PMID:15034926]"}
{"concept_id": "C2262718", "aliases": [], "types": ["T043"], "canonical_name": "astral spindle assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes. [GOC:tb]"}
{"concept_id": "C2262719", "aliases": [], "types": ["T043"], "canonical_name": "astral spindle assembly involved in male meiosis", "definition": "The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells. [GOC:tb]"}
{"concept_id": "C2262720", "aliases": ["ATP-binding cassette (ABC) transporter complex location, integrated substrate binding"], "types": ["T026"], "canonical_name": "ATP-binding cassette (ABC) transporter complex, integrated substrate binding", "definition": "A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a half transporter. Two half-transporters come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP. [GOC:mlg, GOC:mtg_sensu]"}
{"concept_id": "C2262721", "aliases": ["ATP-binding cassette (ABC) transporter complex location, substrate-binding subunit-containing"], "types": ["T026"], "canonical_name": "ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing", "definition": "A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP. [GOC:mlg, GOC:mtg_sensu]"}
{"concept_id": "C2262722", "aliases": ["mannose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "mannose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+. [GOC:ct]"}
{"concept_id": "C2262723", "aliases": ["fructose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "fructose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+. [GOC:ct]"}
{"concept_id": "C2262724", "aliases": ["D-glucose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "D-glucose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose. [GOC:ct]"}
{"concept_id": "C2262725", "aliases": [], "types": ["T044"], "canonical_name": "D-glucose transmembrane transporter activity", "definition": "Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other. [GOC:jid, GOC:jsg, GOC:mah]"}
{"concept_id": "C2262726", "aliases": [], "types": ["T043"], "canonical_name": "symmetric neuroblast division", "definition": "The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells. [GOC:dph]"}
{"concept_id": "C2262727", "aliases": [], "types": ["T043"], "canonical_name": "asymmetric neuroblast division", "definition": "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. [GOC:dph]"}
{"concept_id": "C2262728", "aliases": [], "types": ["T043"], "canonical_name": "asymmetric neuroblast division resulting in ganglion mother cell formation", "definition": "Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell. [GOC:dph]"}
{"concept_id": "C2262729", "aliases": [], "types": ["T040"], "canonical_name": "phosphate ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. [GOC:jid, GOC:mah]"}
{"concept_id": "C2262730", "aliases": [], "types": ["T040"], "canonical_name": "chloride ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell. [GOC:jid, GOC:mah]"}
{"concept_id": "C2262731", "aliases": [], "types": ["T043"], "canonical_name": "metal ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]"}
{"concept_id": "C2262733", "aliases": [], "types": ["T043"], "canonical_name": "monovalent inorganic cation homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]"}
{"concept_id": "C2262734", "aliases": ["cobalt ion homeostasis"], "types": ["T040"], "definition": "Any process involved in the maintenance of an internal steady state of cobalt ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]", "canonical_name": "cobalt homeostasis"}
{"concept_id": "C2262735", "aliases": ["zinc ion homeostasis"], "types": ["T040"], "definition": "Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]", "canonical_name": "zinc homeostasis"}
{"concept_id": "C2262736", "aliases": [], "types": ["T040"], "definition": "Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]", "canonical_name": "copper ion homeostasis"}
{"concept_id": "C2262737", "aliases": ["manganese homeostasis"], "types": ["T040"], "definition": "Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell. [GOC:jid, GOC:mah]", "canonical_name": "manganese ion homeostasis"}
{"concept_id": "C2262738", "aliases": [], "types": ["T040"], "canonical_name": "transition metal ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [GOC:jid, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2262739", "aliases": [], "types": ["T039"], "canonical_name": "cation homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of cations within an organism or cell. [GOC:ceb, GOC:jid, GOC:mah]"}
{"concept_id": "C2262740", "aliases": [], "types": ["T039"], "canonical_name": "cellular chemical homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell. [GOC:isa_complete, GOC:jid]"}
{"concept_id": "C2262741", "aliases": [], "types": ["T040"], "canonical_name": "fruiting body development in response to starvation"}
{"concept_id": "C2262742", "aliases": ["nucleobase, nucleoside and nucleotide metabolism"], "types": ["T045"], "canonical_name": "nucleobase-containing small molecule metabolic process", "definition": "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. [GOC:vw]"}
{"concept_id": "C2262743", "aliases": ["Ski complex location"], "types": ["T026"], "canonical_name": "Ski complex", "definition": "A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p. [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509, PMID:18042677]"}
{"concept_id": "C2262744", "aliases": [], "types": ["T039"], "canonical_name": "lipid homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262745", "aliases": [], "types": ["T039"], "canonical_name": "fatty acid homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262746", "aliases": ["glyceride homeostasis"], "types": ["T039"], "canonical_name": "acylglycerol homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262747", "aliases": [], "types": ["T039"], "canonical_name": "phospholipid homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262748", "aliases": [], "types": ["T039"], "canonical_name": "sterol homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of sterol within an organism or cell. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262749", "aliases": ["response to increased oxygen tension", "response to hyperoxic stress"], "types": ["T046"], "canonical_name": "response to hyperoxia", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. [GOC:kmv]"}
{"concept_id": "C2262751", "aliases": ["lipoprotein particle-mediated signaling", "lipoprotein mediated signalling", "lipoprotein particle mediated signal transduction"], "types": ["T044"], "canonical_name": "lipoprotein particle mediated signaling", "definition": "The series of molecular signals mediated by the detection of a lipoprotein particle. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262752", "aliases": ["low-density lipoprotein mediated signalling", "low-density lipoprotein particle-mediated signaling", "low-density lipoprotein particle mediated signal transduction"], "types": ["T044"], "canonical_name": "low-density lipoprotein particle mediated signaling", "definition": "The series of molecular signals mediated by the detection of low-density lipoprotein particle. [GOC:BHF, GOC:rl, PMID:16013438]"}
{"concept_id": "C2262753", "aliases": ["high density lipoprotein mediated signalling", "high density lipoprotein particle-mediated signaling", "high density lipoprotein particle mediated signal transduction"], "types": ["T044"], "canonical_name": "high density lipoprotein particle mediated signaling", "definition": "The series of molecular signals mediated by the detection of high density lipoprotein particle. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262756", "aliases": [], "types": ["T044"], "canonical_name": "adiponectin binding", "definition": "Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism. [GOC:BHF, GOC:rl, PMID:15210937]"}
{"concept_id": "C2262758", "aliases": [], "types": ["T044"], "canonical_name": "lipase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262759", "aliases": [], "types": ["T044"], "canonical_name": "ligase regulator activity", "definition": "Binds to and modulates the activity of a ligase. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262760", "aliases": [], "types": ["T044"], "canonical_name": "ligase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a ligase. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262761", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin-protein transferase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262762", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin-protein transferase regulator activity", "definition": "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2262763", "aliases": [], "types": ["T043"], "canonical_name": "Golgi to secretory granule transport", "definition": "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex. [GOC:curators]"}
{"concept_id": "C2262764", "aliases": [], "types": ["T043"], "canonical_name": "Golgi to transport vesicle transport", "definition": "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. [GOC:jid]"}
{"concept_id": "C2262765", "aliases": [], "types": ["T042"], "canonical_name": "invagination involved in gastrulation with mouth forming second", "definition": "The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation. [ISBN:0878932437]"}
{"concept_id": "C2262766", "aliases": [], "types": ["T042"], "canonical_name": "involution involved in gastrulation with mouth forming second", "definition": "The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation. [ISBN:0878932437]"}
{"concept_id": "C2262767", "aliases": [], "types": ["T043"], "canonical_name": "ingression involved in gastrulation with mouth forming second", "definition": "The migration of individual cells into the embryo involved in deuterostomic gastrulation. [ISBN:0878932437]"}
{"concept_id": "C2262768", "aliases": [], "types": ["T043"], "canonical_name": "delamination involved in gastrulation with mouth forming second", "definition": "The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation. [ISBN:0878932437]"}
{"concept_id": "C2262769", "aliases": [], "types": ["T042"], "canonical_name": "epiboly involved in gastrulation with mouth forming second", "definition": "The expansion of one cell sheet over other cells involved in deuterostomic gastrulation. [ISBN:0878932437]"}
{"concept_id": "C2262770", "aliases": [], "types": ["T039"], "canonical_name": "pharyngeal system development", "definition": "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. [GOC:dph]"}
{"concept_id": "C2262771", "aliases": ["heart muscle cell proliferation", "cardiac myocyte proliferation"], "types": ["T043"], "canonical_name": "cardiac muscle cell proliferation", "definition": "The expansion of a cardiac muscle cell population by cell division. [GOC:dph, GOC:rph, PMID:11161571]"}
{"concept_id": "C2262772", "aliases": [], "types": ["T043"], "canonical_name": "cardiomyocyte proliferation"}
{"concept_id": "C2262773", "aliases": [], "types": ["T042"], "canonical_name": "pericardium development", "definition": "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438]"}
{"concept_id": "C2262774", "aliases": [], "types": ["T043"], "canonical_name": "retinal bipolar neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina. [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]"}
{"concept_id": "C2262775", "aliases": ["retina development in camera-style eye"], "types": ["T042"], "canonical_name": "retina development in camera-type eye", "definition": "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. [GOC:bf, GOC:dph, ISBN:0815340729]"}
{"concept_id": "C2262776", "aliases": ["retinogenesis", "retina morphogenesis in camera-style eye"], "types": ["T042"], "canonical_name": "retina morphogenesis in camera-type eye", "definition": "The process in which the anatomical structure of the retina is generated and organized. [GOC:bf, GOC:dph, GOC:mtg_sensu]"}
{"concept_id": "C2262777", "aliases": ["regulation of heart muscle cell proliferation"], "types": ["T043"], "canonical_name": "regulation of cardiac muscle cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]"}
{"concept_id": "C2262778", "aliases": ["negative regulation of heart muscle cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of cardiac muscle cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]"}
{"concept_id": "C2262779", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cardiac muscle cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]"}
{"concept_id": "C2262780", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of heart muscle cell proliferation"}
{"concept_id": "C2262781", "aliases": [], "types": ["T043"], "canonical_name": "regulation of acrosome reaction", "definition": "Any process that modulates the frequency, rate or extent of the acrosome reaction. [GOC:dph]"}
{"concept_id": "C2262782", "aliases": ["regulation of protein amino acid glycosylation"], "types": ["T040"], "canonical_name": "regulation of protein glycosylation", "definition": "Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:dms, GOC:dph, GOC:pr]"}
{"concept_id": "C2262783", "aliases": ["positive regulation of protein amino acid glycosylation"], "types": ["T040"], "canonical_name": "positive regulation of protein glycosylation", "definition": "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:dms, GOC:dph, GOC:pr]"}
{"concept_id": "C2262784", "aliases": ["negative regulation of protein amino acid glycosylation"], "types": ["T044"], "canonical_name": "negative regulation of protein glycosylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:dms, GOC:dph, GOC:pr]"}
{"concept_id": "C2262785", "aliases": ["neurofilament cytoskeleton organisation", "neurofilament cytoskeleton organization and biogenesis"], "types": ["T043"], "canonical_name": "neurofilament cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins. [GOC:dph]"}
{"concept_id": "C2262786", "aliases": [], "types": ["T026"], "canonical_name": "neurofilament cytoskeleton", "definition": "Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons. [GOC:dph]"}
{"concept_id": "C2262787", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of epithelial cell proliferation involved in wound healing", "definition": "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury. [GOC:dph]"}
{"concept_id": "C2262788", "aliases": [], "types": ["T042"], "canonical_name": "angiogenesis involved in wound healing", "definition": "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. [GOC:dph, PMID:15039218]"}
{"concept_id": "C2262789", "aliases": [], "types": ["T039"], "canonical_name": "mammary gland involution", "definition": "The tissue remodeling that removes differentiated mammary epithelia during weaning. [GOC:dph, PMID:15282149]"}
{"concept_id": "C2262790", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in mammary gland involution"}
{"concept_id": "C2262791", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of apoptosis involved in mammary gland involution"}
{"concept_id": "C2262792", "aliases": [], "types": ["T040"], "canonical_name": "embryonic retina morphogenesis in camera-type eye", "definition": "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage. [GOC:dgh, GOC:dph]"}
{"concept_id": "C2262793", "aliases": [], "types": ["T042"], "canonical_name": "post-embryonic retina morphogenesis in camera-type eye", "definition": "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage. [GOC:dgh, GOC:dph]"}
{"concept_id": "C2262794", "aliases": ["Spemann-Mangold organizer formation", "Spemann's organizer formation"], "types": ["T042"], "canonical_name": "Spemann organizer formation", "definition": "Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan. [GOC:bf, GOC:dph]"}
{"concept_id": "C2262795", "aliases": ["Spemann-Mangold organizer formation at the dorsal lip of the blastopore", "Spemann's organizer formation at the dorsal lip of the blastopore"], "types": ["T040"], "canonical_name": "Spemann organizer formation at the dorsal lip of the blastopore", "definition": "Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan. [GOC:dph, PMID:9442883]"}
{"concept_id": "C2262797", "aliases": ["Spemann's organizer formation at the embryonic shield", "Spemann-Mangold organizer formation at the embryonic shield"], "types": ["T040"], "canonical_name": "Spemann organizer formation at the embryonic shield", "definition": "Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan. [GOC:dph, PMID:9442883]"}
{"concept_id": "C2262798", "aliases": ["Spemann's organizer formation at the anterior end of the primitive streak"], "types": ["T040"], "canonical_name": "Spemann organizer formation at the anterior end of the primitive streak", "definition": "Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan. [GOC:dph, PMID:9442883]"}
{"concept_id": "C2262799", "aliases": [], "types": ["T040"], "canonical_name": "Spemann organizer formation in amniotes"}
{"concept_id": "C2262800", "aliases": [], "types": ["T040"], "canonical_name": "Spemann-Mangold organizer formation at the anterior end of the primitive streak"}
{"concept_id": "C2262801", "aliases": [], "types": ["T040"], "canonical_name": "uterus development", "definition": "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. [GOC:dph, GOC:ebc]"}
{"concept_id": "C2262802", "aliases": ["Mullerian tract development"], "types": ["T040"], "canonical_name": "Mullerian tract development"}
{"concept_id": "C2262803", "aliases": [], "types": ["T040"], "canonical_name": "fallopian tube development"}
{"concept_id": "C2262804", "aliases": [], "types": ["T040"], "canonical_name": "cervix development", "definition": "The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure. [GOC:dph, GOC:ebc]"}
{"concept_id": "C2262805", "aliases": [], "types": ["T040"], "canonical_name": "vagina development", "definition": "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure. [GOC:dph, GOC:ebc]"}
{"concept_id": "C2262806", "aliases": ["Wnt-activated signaling pathway, regulating spindle positioning", "Wnt receptor signaling pathway, regulating spindle positioning", "Wnt receptor signalling pathway, regulating spindle positioning"], "types": ["T044"], "canonical_name": "Wnt signaling pathway, regulating spindle positioning", "definition": "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle. [GOC:bf, GOC:dph, PMID:11532397]"}
{"concept_id": "C2262807", "aliases": ["non-canonical Wnt-activated signaling pathway", "non-canonical Wnt signaling pathway", "beta-catenin-independent Wnt receptor signaling pathway", "non-canonical Wnt receptor signaling pathway", "non-canonical Wnt receptor signalling pathway"], "types": ["T044"], "canonical_name": "non-canonical Wnt signaling pathway", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. [GOC:signaling]"}
{"concept_id": "C2262808", "aliases": ["canonical Wnt receptor signaling pathway", "Wnt receptor signaling pathway through beta-catenin", "canonical Wnt-activated signaling pathway", "Wnt receptor signaling pathway via beta-catenin", "canonical Wnt signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]", "canonical_name": "Wnt receptor signalling pathway through beta-catenin"}
{"concept_id": "C2262809", "aliases": [], "types": ["T044"], "canonical_name": "frizzled-1 receptor signaling pathway"}
{"concept_id": "C2262810", "aliases": ["Wnt receptor signaling pathway, planar cell polarity pathway", "Wnt receptor signalling pathway, planar cell polarity pathway", "Wnt-activated signaling pathway, planar cell polarity pathway", "planar cell polarity pathway", "PCP pathway"], "types": ["T044"], "canonical_name": "Wnt signaling pathway, planar cell polarity pathway", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity. [GOC:bf, GOC:dph, PMID:11532397]"}
{"concept_id": "C2262811", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway"}
{"concept_id": "C2262812", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-PCP signaling pathway"}
{"concept_id": "C2262813", "aliases": ["BK KCa channel activity", "BK calcium-activated potassium channel activity", "large conductance KCa channel activity"], "types": ["T044"], "canonical_name": "large conductance calcium-activated potassium channel activity", "definition": "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, ISBN:0815340729, PMID:17115074]"}
{"concept_id": "C2262814", "aliases": [], "types": ["T044"], "canonical_name": "BK channel activity"}
{"concept_id": "C2262815", "aliases": ["synaptic maturation"], "types": ["T042"], "canonical_name": "synapse maturation", "definition": "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development. [GOC:dph, GOC:ef]"}
{"concept_id": "C2262816", "aliases": ["regulation of resting potential"], "types": ["T043"], "canonical_name": "regulation of resting membrane potential", "definition": "Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized. [GOC:dph, GOC:ef, ISBN:0195088433]"}
{"concept_id": "C2262817", "aliases": ["regulation of post-synaptic membrane potential"], "types": ["T043"], "canonical_name": "regulation of postsynaptic membrane potential", "definition": "Any process that modulates the potential difference across a post-synaptic membrane. [GOC:dph, GOC:ef]"}
{"concept_id": "C2262818", "aliases": ["regulation of excitatory post-synaptic membrane potential"], "types": ["T043"], "definition": "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]", "canonical_name": "excitatory postsynaptic potential"}
{"concept_id": "C2262819", "aliases": ["regulation of inhibitory post-synaptic membrane potential", "inhibitory postsynaptic potential"], "types": ["T043"], "definition": "A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. [GOC:dph, GOC:ef]", "canonical_name": "IPSP"}
{"concept_id": "C2262820", "aliases": [], "types": ["T043"], "canonical_name": "membrane hyperpolarization", "definition": "The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. [GOC:dph]"}
{"concept_id": "C2262821", "aliases": ["nictitating membrane reflex"], "types": ["T039"], "canonical_name": "eye blink reflex", "definition": "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing. [GOC:dph, PMID:2913208]"}
{"concept_id": "C2262822", "aliases": [], "types": ["T042"], "canonical_name": "smooth muscle contraction involved in micturition", "definition": "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body. [GOC:dph, PMID:15827347]"}
{"concept_id": "C2262823", "aliases": [], "types": ["T042"], "canonical_name": "smooth muscle contraction involved in urination"}
{"concept_id": "C2262824", "aliases": [], "types": ["T043"], "canonical_name": "synaptic transmission involved in micturition", "definition": "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body. [GOC:dph, PMID:15827347]"}
{"concept_id": "C2262826", "aliases": ["synaptic transmission involved in urination"], "types": ["T040"], "canonical_name": "smooth muscle relaxation of the bladder outlet", "definition": "A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body. [GOC:dph, PMID:15827347]"}
{"concept_id": "C2262827", "aliases": ["circadian thermoregulation"], "types": ["T040"], "canonical_name": "circadian temperature homeostasis", "definition": "Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262828", "aliases": [], "types": ["T040"], "canonical_name": "circadian regulation of body temperature"}
{"concept_id": "C2262829", "aliases": ["relaxation of vascular smooth muscle", "vascular smooth muscle relaxation"], "types": ["T040"], "canonical_name": "relaxation of vascular associated smooth muscle", "definition": "A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:dph, GOC:rph, GOC:TermGenie, PMID:15867178, PMID:19996365, PMID:27389411]"}
{"concept_id": "C2262830", "aliases": ["auditory receptor cell stereocilium organization and biogenesis", "auditory receptor cell stereocilium organisation"], "types": ["T043"], "canonical_name": "auditory receptor cell stereocilium organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells. [GOC:dph, PMID:10978835]"}
{"concept_id": "C2262831", "aliases": [], "types": ["T044"], "canonical_name": "molecular transducer activity", "definition": "A compound molecular function in which an effector function is controlled by one or more regulatory components. [GOC:dos, GOC:pdt]"}
{"concept_id": "C2262832", "aliases": ["binding, bridging"], "types": ["T044"], "canonical_name": "molecular adaptor activity", "definition": "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]"}
{"concept_id": "C2262833", "aliases": [], "types": ["T040"], "canonical_name": "regulation of synaptic transmission, glycinergic", "definition": "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. [GOC:dms, GOC:dph]"}
{"concept_id": "C2262834", "aliases": ["negative regulation of glycinergic synaptic transmission"], "types": ["T040"], "canonical_name": "negative regulation of synaptic transmission, glycinergic", "definition": "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. [GOC:dms, GOC:dph]"}
{"concept_id": "C2262835", "aliases": ["positive regulation of glycinergic synaptic transmission"], "types": ["T040"], "canonical_name": "positive regulation of synaptic transmission, glycinergic", "definition": "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. [GOC:dms, GOC:dph]"}
{"concept_id": "C2262836", "aliases": ["zinc potentiation of glycinergic synaptic transmission"], "types": ["T042"], "canonical_name": "zinc potentiation of synaptic transmission, glycinergic", "definition": "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. [GOC:dms, GOC:dph]"}
{"concept_id": "C2262837", "aliases": [], "types": ["T043"], "canonical_name": "serotonin secretion, neurotransmission", "definition": "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C2262838", "aliases": [], "types": ["T043"], "canonical_name": "cytoskeletal rearrangement involved in phagocytosis, engulfment", "definition": "The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. [GOC:dph]"}
{"concept_id": "C2262839", "aliases": ["membrane reorganisation involved in phagocytosis, engulfment"], "types": ["T043"], "canonical_name": "membrane reorganization involved in phagocytosis, engulfment", "definition": "The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. [GOC:dph]"}
{"concept_id": "C2262840", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phagocytosis, engulfment", "definition": "Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. [GOC:dph]"}
{"concept_id": "C2262841", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of phagocytosis, engulfment", "definition": "Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. [GOC:dph]"}
{"concept_id": "C2262842", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of phagocytosis, engulfment", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. [GOC:dph]"}
{"concept_id": "C2262843", "aliases": [], "types": ["T026"], "canonical_name": "collagen and cuticulin-based cuticle extracellular matrix", "definition": "A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans. [GOC:dph, GOC:kmv, ISSN:15518507]"}
{"concept_id": "C2262845", "aliases": [], "types": ["T026"], "canonical_name": "collagen and cuticulin-based exoskeleton extracellular matrix"}
{"concept_id": "C2262847", "aliases": [], "types": ["T026"], "canonical_name": "surface coat of collagen and cuticulin-based cuticle extracellular matrix", "definition": "An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans. [GOC:dph, GOC:kmv, ISSN:15518507]"}
{"concept_id": "C2262849", "aliases": [], "types": ["T026"], "canonical_name": "surface coat of collagen and cuticulin-based exoskeleton extracellular matrix"}
{"concept_id": "C2262850", "aliases": [], "types": ["T026"], "canonical_name": "epicuticle of collagen and cuticulin-based cuticle extracellular matrix", "definition": "A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans. [GOC:dph, GOC:kmv, ISSN:15518507]"}
{"concept_id": "C2262852", "aliases": [], "types": ["T026"], "canonical_name": "epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix"}
{"concept_id": "C2262853", "aliases": [], "types": ["T026"], "canonical_name": "cortical layer of collagen and cuticulin-based cuticle extracellular matrix", "definition": "The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans. [GOC:dph, GOC:kmv, ISSN:15518507]"}
{"concept_id": "C2262856", "aliases": [], "types": ["T026"], "canonical_name": "annuli extracellular matrix", "definition": "The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present. [GOC:dph, GOC:kmv, ISSN:15518507]"}
{"concept_id": "C2262857", "aliases": [], "types": ["T026"], "canonical_name": "annulae"}
{"concept_id": "C2262858", "aliases": [], "types": ["T026"], "canonical_name": "annular rings"}
{"concept_id": "C2262859", "aliases": [], "types": ["T026"], "canonical_name": "annule(s)"}
{"concept_id": "C2262860", "aliases": [], "types": ["T026"], "canonical_name": "annulus"}
{"concept_id": "C2262861", "aliases": [], "types": ["T026"], "canonical_name": "annular furrow extracellular matrix", "definition": "The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline. [GOC:dph, GOC:kmv, ISSN:15518507]"}
{"concept_id": "C2262862", "aliases": [], "types": ["T026"], "canonical_name": "medial layer of collagen and cuticulin-based cuticle extracellular matrix", "definition": "The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals. [GOC:dph, GOC:kmv, ISSN:15518507]"}
{"concept_id": "C2262863", "aliases": [], "types": ["T026"], "canonical_name": "medial layer struts"}
{"concept_id": "C2262864", "aliases": [], "types": ["T026"], "canonical_name": "basal layer of collagen and cuticulin-based cuticle extracellular matrix", "definition": "The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans. [GOC:dph, GOC:kmv, ISSN:15518507]"}
{"concept_id": "C2262866", "aliases": [], "types": ["T026"], "canonical_name": "basal layer of collagen and cuticulin-based exoskeleton extracellular matrix"}
{"concept_id": "C2262867", "aliases": [], "types": ["T026"], "canonical_name": "alae of collagen and cuticulin-based cuticle extracellular matrix", "definition": "Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively. [GOC:dph, GOC:kmv, ISSN:15518507]"}
{"concept_id": "C2262869", "aliases": [], "types": ["T026"], "canonical_name": "alae of collagen and cuticulin-based exoskeleton extracellular matrix"}
{"concept_id": "C2262870", "aliases": ["generation of estrus cycle rhythm", "generation of oestrus cycle rhythm"], "types": ["T040"], "canonical_name": "generation of ovulation cycle rhythm", "definition": "The process which controls the timing of the type of sexual cycle seen in female mammals. [GOC:dph]"}
{"concept_id": "C2262871", "aliases": [], "types": ["T040"], "canonical_name": "generation of menstrual cycle rhythm"}
{"concept_id": "C2262872", "aliases": ["inner ear hair cell differentiation"], "types": ["T043"], "canonical_name": "inner ear receptor cell differentiation", "definition": "The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound. [GOC:dph]"}
{"concept_id": "C2262873", "aliases": ["vestibular hair cell differentiation"], "types": ["T043"], "canonical_name": "vestibular receptor cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell. [GOC:dph]"}
{"concept_id": "C2262874", "aliases": ["vestibular hair cell fate commitment"], "types": ["T043"], "canonical_name": "vestibular receptor cell fate commitment", "definition": "The process in which a cell becomes committed to become a vestibular receptor cell. [GOC:dph]"}
{"concept_id": "C2262875", "aliases": ["vestibular hair cell morphogenesis"], "types": ["T043"], "canonical_name": "vestibular receptor cell morphogenesis", "definition": "Any process that alters the size or shape of a vestibular receptor cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262876", "aliases": ["auditory hair cell development"], "types": ["T043"], "canonical_name": "auditory receptor cell development", "definition": "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:dph]"}
{"concept_id": "C2262877", "aliases": ["vestibular hair cell development"], "types": ["T043"], "canonical_name": "vestibular receptor cell development", "definition": "The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:dph]"}
{"concept_id": "C2262878", "aliases": ["inner ear hair cell development"], "types": ["T043"], "canonical_name": "inner ear receptor cell development", "definition": "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:dph]"}
{"concept_id": "C2262879", "aliases": ["inner ear hair cell fate commitment"], "types": ["T043"], "canonical_name": "inner ear receptor cell fate commitment", "definition": "The process in which a cell becomes committed to become an inner ear receptor cell. [GOC:dph]"}
{"concept_id": "C2262880", "aliases": ["vestibular receptor cell stereocilium organization and biogenesis", "vestibular receptor cell stereocilium organisation", "vestibular hair cell stereocilium organization"], "types": ["T043"], "canonical_name": "vestibular receptor cell stereocilium organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells. [GOC:dph]"}
{"concept_id": "C2262881", "aliases": ["inner ear receptor stereocilium organisation", "inner ear hair cell receptor stereocilium organization", "inner ear receptor stereocilium organization and biogenesis"], "types": ["T043"], "canonical_name": "inner ear receptor cell stereocilium organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. [GOC:dph]"}
{"concept_id": "C2262882", "aliases": [], "types": ["T040"], "canonical_name": "regulation of growth hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell. [GOC:dph]"}
{"concept_id": "C2262883", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of growth hormone secretion", "definition": "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell. [GOC:dph]"}
{"concept_id": "C2262884", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of growth hormone secretion", "definition": "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell. [GOC:dph]"}
{"concept_id": "C2262885", "aliases": ["somatotrophin secreting cell differentiation", "growth hormone secreting cell differentiation"], "types": ["T043"], "canonical_name": "somatotropin secreting cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin. [GOC:dph]"}
{"concept_id": "C2262887", "aliases": [], "types": ["T043"], "canonical_name": "somatotrope differentiation"}
{"concept_id": "C2262888", "aliases": [], "types": ["T043"], "canonical_name": "somatotroph differentiation"}
{"concept_id": "C2262889", "aliases": [], "types": ["T043"], "canonical_name": "somatotropic cell differentiation"}
{"concept_id": "C2262890", "aliases": [], "types": ["T043"], "canonical_name": "somatrophic cell differentiation"}
{"concept_id": "C2262891", "aliases": ["lactotrope differentiation", "lactotropic cell differentiation", "mammotrope differentiation", "mammotroph differentiation", "lactotroph differentiation", "epsilon-acidophil differentiation", "mammotropic cell differentiation", "mammotrophic cell differentiation"], "types": ["T043"], "canonical_name": "prolactin secreting cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin. [GOC:dph]"}
{"concept_id": "C2262892", "aliases": ["corticotrophin hormone secreting cell differentiation", "adrenocorticotropic hormone secreting cell differentiation", "corticotrope differentiation", "adrenocorticotrophic hormone secreting cell differentiation", "corticotroph differentiation"], "types": ["T043"], "canonical_name": "corticotropin hormone secreting cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin. [GOC:dph]"}
{"concept_id": "C2262894", "aliases": ["beta-basophil differentiation", "TSH-secreting cell differentiation", "thyrotroph differentiation", "thyroid stimulating hormone secreting cell differentiation", "thyrotrope differentiation"], "types": ["T043"], "canonical_name": "thyroid-stimulating hormone-secreting cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin. [GOC:dph]"}
{"concept_id": "C2262895", "aliases": ["thyrotroph development", "thyrotrope development", "thyroid stimulating hormone secreting cell development", "TSH-secreting cell development", "beta-basophil development"], "types": ["T043"], "canonical_name": "thyroid-stimulating hormone-secreting cell development", "definition": "The process whose specific outcome is the progression of a thyroid-stimulating hormone-secreting cell over time, from its formation to the mature structure. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. [GOC:dph]"}
{"concept_id": "C2262896", "aliases": ["adrenocorticotrophic hormone secreting cell development", "corticotrophin hormone secreting cell development", "corticotrope development", "adrenocorticotropic hormone secreting cell development"], "types": ["T043"], "canonical_name": "corticotropin hormone secreting cell development", "definition": "The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin. [GOC:dph]"}
{"concept_id": "C2262897", "aliases": [], "types": ["T043"], "canonical_name": "corticotroph development"}
{"concept_id": "C2262899", "aliases": ["epsilon-acidophil development", "lactotrope development", "mammotropic cell development", "lactotropic cell development", "mammotroph development", "lactotroph development", "mammotrope development", "mammotrophic cell development"], "types": ["T043"], "canonical_name": "prolactin secreting cell development", "definition": "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin. [GOC:dph]"}
{"concept_id": "C2262900", "aliases": ["growth hormone secreting cell development", "somatotrophin secreting cell development", "somatotropic cell development"], "types": ["T043"], "canonical_name": "somatotropin secreting cell development", "definition": "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin. [GOC:dph]"}
{"concept_id": "C2262902", "aliases": [], "types": ["T043"], "canonical_name": "somatotrope development"}
{"concept_id": "C2262903", "aliases": [], "types": ["T043"], "canonical_name": "somatotroph development"}
{"concept_id": "C2262904", "aliases": [], "types": ["T043"], "canonical_name": "somatrophic cell development"}
{"concept_id": "C2262905", "aliases": [], "types": ["T039"], "canonical_name": "maternal process involved in female pregnancy", "definition": "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. [GOC:dph]"}
{"concept_id": "C2262906", "aliases": [], "types": ["T040"], "canonical_name": "embryonic process involved in female pregnancy", "definition": "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. [GOC:dph]"}
{"concept_id": "C2262907", "aliases": [], "types": ["T039"], "canonical_name": "maternal process involved in parturition", "definition": "A reproductive process occurring in the mother that results in birth. [GOC:dph]"}
{"concept_id": "C2262908", "aliases": [], "types": ["T039"], "canonical_name": "fetal process involved in parturition", "definition": "A reproductive process occurring in the embryo that results in birth. [GOC:dph]"}
{"concept_id": "C2262909", "aliases": ["positive regulation of apoptosis by virus"], "types": ["T043"], "canonical_name": "positive regulation of apoptotic process by virus", "definition": "Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:dph, GOC:mtg_apoptosis]"}
{"concept_id": "C2262912", "aliases": [], "types": ["T043"], "canonical_name": "regulation of syncytium formation by plasma membrane fusion", "definition": "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:dph]"}
{"concept_id": "C2262913", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of syncytium formation by plasma membrane fusion", "definition": "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:dph]"}
{"concept_id": "C2262917", "aliases": ["regulation of posttranscriptional gene silencing"], "types": ["T045"], "canonical_name": "regulation of post-transcriptional gene silencing", "definition": "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. [GOC:dph]"}
{"concept_id": "C2262918", "aliases": ["positive regulation of posttranscriptional gene silencing"], "types": ["T045"], "canonical_name": "positive regulation of post-transcriptional gene silencing", "definition": "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. [GOC:dph]"}
{"concept_id": "C2262919", "aliases": ["negative regulation of posttranscriptional gene silencing"], "types": ["T043"], "canonical_name": "negative regulation of post-transcriptional gene silencing", "definition": "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. [GOC:dph]"}
{"concept_id": "C2262921", "aliases": ["peroxisome localisation"], "types": ["T039"], "canonical_name": "peroxisome localization", "definition": "Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. [GOC:dph, PMID:16449325]"}
{"concept_id": "C2262922", "aliases": ["microtubule-based peroxisome localisation"], "types": ["T043"], "canonical_name": "microtubule-based peroxisome localization", "definition": "The microtubule-based process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. [GOC:dph, PMID:16449325]"}
{"concept_id": "C2262923", "aliases": ["regulation by virus of host cell cycle", "modulation of host cell cycle by virus", "regulation of host cell cycle by virus", "viral process regulating host cell cycle"], "types": ["T043"], "canonical_name": "modulation by virus of host cell cycle", "definition": "Any viral process that modulates the rate or extent of progression through the cell cycle. [GOC:dph, UniProtKB-KW:KW-1121, VZ:1636]"}
{"concept_id": "C2262925", "aliases": ["platelet dense granule organization and biogenesis", "platelet dense granule organisation"], "types": ["T043"], "canonical_name": "platelet dense granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. [GOC:dph, PMID:11487378]"}
{"concept_id": "C2262926", "aliases": [], "types": ["T043"], "canonical_name": "bull's eye body organization and biogenesis"}
{"concept_id": "C2262927", "aliases": [], "types": ["T043"], "canonical_name": "platelet dense body organization and biogenesis"}
{"concept_id": "C2262928", "aliases": [], "types": ["T039"], "canonical_name": "urinary bladder development", "definition": "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion. [GOC:dph, GOC:ln, GOC:mr, PMID:11768524, PMID:18276178, PMID:538956]"}
{"concept_id": "C2262929", "aliases": ["phospholipase C-activating dopamine receptor signaling pathway", "dopamine receptor, phospholipase C activating pathway", "activation of phospholipase C activity by dopamine receptor signaling pathway", "activation of phospholipase C activity by dopamine receptor signalling pathway"], "types": ["T044"], "canonical_name": "phospholipase C-activating dopamine receptor signaling pathway", "definition": "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:signaling, GOC:tb, PMID:12675914]"}
{"concept_id": "C2262930", "aliases": ["regulation of dopamine receptor signalling pathway"], "types": ["T043"], "canonical_name": "regulation of dopamine receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. [GOC:dph]"}
{"concept_id": "C2262931", "aliases": ["negative regulation of dopamine receptor signalling pathway"], "types": ["T040"], "canonical_name": "negative regulation of dopamine receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. [GOC:dph]"}
{"concept_id": "C2262932", "aliases": ["positive regulation of dopamine receptor signalling pathway"], "types": ["T043"], "canonical_name": "positive regulation of dopamine receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. [GOC:dph]"}
{"concept_id": "C2262933", "aliases": ["down-regulation of phospholipase C-activating dopamine receptor signaling pathway", "negative regulation of phospholipase C-activating dopamine receptor signaling pathway", "down regulation of phospholipase C-activating dopamine receptor signaling pathway", "negative regulation of dopamine receptor, phospholipase C activating pathway", "negative regulation of phospholipase C-activating dopamine receptor signalling pathway"], "types": ["T043"], "canonical_name": "negative regulation of phospholipase C-activating dopamine receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway. [GOC:dph, GOC:tb, PMID:15016423]"}
{"concept_id": "C2262934", "aliases": [], "types": ["T043"], "canonical_name": "subpallium neuron fate commitment", "definition": "The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon. [GOC:dph]"}
{"concept_id": "C2262935", "aliases": [], "types": ["T043"], "canonical_name": "subpallium neuronal precursor fate commitment"}
{"concept_id": "C2262936", "aliases": [], "types": ["T043"], "canonical_name": "regulation of timing of neuron differentiation", "definition": "The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron. [GOC:dph]"}
{"concept_id": "C2262937", "aliases": [], "types": ["T043"], "canonical_name": "regulation of timing of subpallium neuron differentiation", "definition": "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon. [GOC:dph]"}
{"concept_id": "C2262938", "aliases": [], "types": ["T042"], "canonical_name": "olfactory pit development", "definition": "The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx. [GOC:dph, ISBN:0124020607]"}
{"concept_id": "C2262939", "aliases": ["regulation of adenosine receptor signalling pathway"], "types": ["T043"], "canonical_name": "regulation of adenosine receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands. [GOC:dph]"}
{"concept_id": "C2262940", "aliases": ["positive regulation of adenosine receptor signalling pathway"], "types": ["T043"], "canonical_name": "positive regulation of adenosine receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands. [GOC:dph]"}
{"concept_id": "C2262941", "aliases": ["negative regulation of adenosine receptor signalling pathway"], "types": ["T043"], "canonical_name": "negative regulation of adenosine receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands. [GOC:dph]"}
{"concept_id": "C2262942", "aliases": [], "types": ["T026"], "canonical_name": "stereocilium membrane", "definition": "The portion of the plasma membrane surrounding a stereocilium. [GOC:dph, GOC:rph]"}
{"concept_id": "C2262944", "aliases": [], "types": ["T042"], "canonical_name": "limb bud development"}
{"concept_id": "C2262945", "aliases": ["limb formation", "limbbud formation"], "types": ["T040"], "canonical_name": "limb bud formation", "definition": "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable. [GOC:dgh, GOC:dph]"}
{"concept_id": "C2262946", "aliases": ["BDNF-activated receptor activity", "brain-derived neurotrophic factor-activated receptor activity"], "types": ["T044"], "canonical_name": "brain-derived neurotrophic factor receptor activity", "definition": "Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:bf, GOC:dph]"}
{"concept_id": "C2262947", "aliases": [], "types": ["T044"], "canonical_name": "BDNF receptor activity"}
{"concept_id": "C2262948", "aliases": [], "types": ["T040"], "canonical_name": "regulation of aggregation involved in sorocarp development", "definition": "Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262949", "aliases": ["regulation of angiotensin metabolism"], "types": ["T040"], "canonical_name": "regulation of angiotensin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262950", "aliases": ["regulation of exocyst localisation"], "types": ["T039"], "canonical_name": "regulation of exocyst localization", "definition": "Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262951", "aliases": [], "types": ["T055"], "canonical_name": "male mating behavior", "definition": "The specific behavior of a male organism that is associated with reproduction. [GOC:dph, GOC:pr, GOC:tb]"}
{"concept_id": "C2262952", "aliases": [], "types": ["T055"], "canonical_name": "female mating behavior", "definition": "The specific behavior of a female organism that is associated with reproduction. [GOC:dph, GOC:pr, GOC:tb]"}
{"concept_id": "C2262954", "aliases": [], "types": ["T044"], "canonical_name": "apelin receptor activity", "definition": "Combining with the peptide apelin to initiate a change in cell activity. [GOC:dph]"}
{"concept_id": "C2262955", "aliases": ["apelin receptor signalling pathway"], "types": ["T044"], "canonical_name": "apelin receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by apelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:dph]"}
{"concept_id": "C2262956", "aliases": [], "types": ["T043"], "canonical_name": "cell cycle switching", "definition": "The process in which a cell switches cell cycle mode. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2262957", "aliases": [], "types": ["T040"], "canonical_name": "outer ear unfolding", "definition": "The opening and spreading out of the outer ear. [GOC:dph]"}
{"concept_id": "C2262958", "aliases": [], "types": ["T040"], "canonical_name": "outer ear emergence", "definition": "The growth of the outer ear. [GOC:dph]"}
{"concept_id": "C2262959", "aliases": [], "types": ["T040"], "canonical_name": "ear elevation"}
{"concept_id": "C2262960", "aliases": [], "types": ["T040"], "canonical_name": "ear extroversion"}
{"concept_id": "C2262961", "aliases": [], "types": ["T040"], "canonical_name": "outer ear growth"}
{"concept_id": "C2262962", "aliases": [], "types": ["T026"], "canonical_name": "cell pole", "definition": "Either of two different areas at opposite ends of an axis of a cell. [GOC:dph]"}
{"concept_id": "C2262963", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein desumoylation", "definition": "Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262964", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of protein desumoylation", "definition": "Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262965", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein desumoylation", "definition": "Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262966", "aliases": [], "types": ["T040"], "canonical_name": "regulation of lipase activity", "definition": "Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262967", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of lipase activity", "definition": "Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. [GOC:dph, GOC:tb]"}
{"concept_id": "C2262968", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of lipase activity", "definition": "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2262969", "aliases": [], "types": ["T045"], "canonical_name": "regulation of antisense RNA transcription", "definition": "Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. [GOC:dph, GOC:jp, GOC:tb, PMID:18075583]"}
{"concept_id": "C2262970", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of antisense RNA transcription", "definition": "Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. [GOC:dph, GOC:tb, PMID:18075583]"}
{"concept_id": "C2262971", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of antisense RNA transcription", "definition": "Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. [GOC:dph, GOC:tb, PMID:18075583]"}
{"concept_id": "C2262972", "aliases": ["cloaca septation"], "types": ["T042"], "canonical_name": "cloacal septation", "definition": "The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development. [GOC:dph, GOC:st]"}
{"concept_id": "C2262973", "aliases": ["clathrin sculpted vesicle"], "types": ["T026"], "canonical_name": "clathrin-sculpted vesicle", "definition": "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. [GOC:dph]"}
{"concept_id": "C2262980", "aliases": ["cytoplasmic membrane-enclosed vesicle lumen"], "types": ["T026"], "canonical_name": "cytoplasmic membrane-bounded vesicle lumen"}
{"concept_id": "C2262981", "aliases": [], "types": ["T040"], "canonical_name": "estrous cycle phase", "definition": "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur. [GOC:dph]"}
{"concept_id": "C2262983", "aliases": [], "types": ["T045"], "canonical_name": "regulation of 3' to 5' mRNA deadenylation"}
{"concept_id": "C2262984", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA deadenylation"}
{"concept_id": "C2262986", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of 3' to 5' mRNA deadenylation"}
{"concept_id": "C2262987", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mRNA deadenylation"}
{"concept_id": "C2262989", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of 3' to 5' mRNA deadenylation"}
{"concept_id": "C2262990", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mRNA deadenylation"}
{"concept_id": "C2262991", "aliases": [], "types": ["T040"], "canonical_name": "endocardium formation", "definition": "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:bf, GOC:dph, PMID:17722983]"}
{"concept_id": "C2262992", "aliases": ["primitive haematopoiesis", "primitive haemopoiesis", "primitive hematopoiesis"], "types": ["T042"], "canonical_name": "primitive hemopoiesis", "definition": "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells. [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]"}
{"concept_id": "C2262993", "aliases": ["definitive haematopoiesis", "definitive haemopoiesis", "definitive hematopoiesis"], "types": ["T043"], "canonical_name": "definitive hemopoiesis", "definition": "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]"}
{"concept_id": "C2262994", "aliases": [], "types": ["T043"], "canonical_name": "hemangioblast cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages. [GOC:bf, GOC:dph, PMID:15378083, PMID:9670018]"}
{"concept_id": "C2262995", "aliases": ["haematopoietic stem cell differentiation", "haemopoietic stem cell differentiation", "hemopoietic stem cell differentiation"], "types": ["T043"], "canonical_name": "hematopoietic stem cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083]"}
{"concept_id": "C2262996", "aliases": [], "types": ["T042"], "canonical_name": "camera-type eye photoreceptor cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2262997", "aliases": [], "types": ["T043"], "canonical_name": "camera-type eye photoreceptor cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye. [GOC:dph]"}
{"concept_id": "C2262998", "aliases": [], "types": ["T042"], "canonical_name": "retinal rod cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. [GOC:dph]"}
{"concept_id": "C2262999", "aliases": [], "types": ["T043"], "canonical_name": "regulation of retinal cone cell fate commitment", "definition": "Any process that modulates the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. [GOC:dph]"}
{"concept_id": "C2263000", "aliases": [], "types": ["T043"], "canonical_name": "retinal rod cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. [GOC:dph]"}
{"concept_id": "C2263001", "aliases": [], "types": ["T043"], "canonical_name": "regulation of retinal rod cell fate commitment", "definition": "Any process that modulates the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. [GOC:dph]"}
{"concept_id": "C2263002", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of retinal rod cell fate commitment", "definition": "Any process that increases the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. [GOC:dph]"}
{"concept_id": "C2263003", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of retinal cone cell fate commitment", "definition": "Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. [GOC:dph]"}
{"concept_id": "C2263004", "aliases": ["Notch signalling pathway involved in camera-type eye photoreceptor fate commitment"], "types": ["T044"], "canonical_name": "Notch signaling pathway involved in camera-type eye photoreceptor fate commitment", "definition": "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a precursor cell to a eye photoreceptor fate. [GOC:dph]"}
{"concept_id": "C2263005", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine-sterol O-acyltransferase activator activity", "definition": "Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615]"}
{"concept_id": "C2263006", "aliases": [], "types": ["T044"], "canonical_name": "LCAT activator activity"}
{"concept_id": "C2263007", "aliases": [], "types": ["T044"], "canonical_name": "lipase activator activity", "definition": "Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2263008", "aliases": [], "types": ["T044"], "canonical_name": "lipoprotein lipase activator activity", "definition": "Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein. [GOC:BHF, GOC:dph, GOC:tb, PMID:10727238]"}
{"concept_id": "C2263012", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of DNA transposition"}
{"concept_id": "C2263013", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA transposition"}
{"concept_id": "C2263014", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of DNA transposition"}
{"concept_id": "C2263015", "aliases": ["cytosolic DNA-directed RNA polymerase complex location"], "types": ["T026"], "canonical_name": "cytosolic DNA-directed RNA polymerase complex", "definition": "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity. [PMID:11158566]"}
{"concept_id": "C2263016", "aliases": [], "types": ["T045"], "canonical_name": "catalytic spliceosome assembly for first transesterification step"}
{"concept_id": "C2263017", "aliases": [], "types": ["T045"], "canonical_name": "catalytic spliceosome assembly for second transesterification step"}
{"concept_id": "C2263018", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud neck septin structure", "definition": "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle. [GOC:krc]"}
{"concept_id": "C2263019", "aliases": ["forked DNA binding"], "types": ["T045"], "canonical_name": "forked DNA binding"}
{"concept_id": "C2263021", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription by galactose"}
{"concept_id": "C2263022", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription by galactose"}
{"concept_id": "C2263023", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription by galactose"}
{"concept_id": "C2263026", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H3-K36 methylation"}
{"concept_id": "C2263027", "aliases": [], "types": ["T040"], "canonical_name": "activation of histone H3-K36 methylation"}
{"concept_id": "C2263028", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of histone H3-K36 methylation"}
{"concept_id": "C2263030", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription from RNA polymerase II promoter by glucose"}
{"concept_id": "C2263031", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription from RNA polymerase II promoter by glucose"}
{"concept_id": "C2263034", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription from RNA polymerase II promoter by glucose"}
{"concept_id": "C2263036", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription from RNA polymerase II promoter by galactose"}
{"concept_id": "C2263037", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription from RNA polymerase II promoter by galactose"}
{"concept_id": "C2263038", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription from RNA polymerase II promoter by galactose"}
{"concept_id": "C2263045", "aliases": ["SSL2-core TFIIH complex portion of holo TFIIH complex", "core TFIIH complex portion of holo TFIIH complex location", "SSL2-core TFIIH complex portion of holo TFIIH complex location"], "types": ["T026"], "canonical_name": "core TFIIH complex portion of holo TFIIH complex", "definition": "The core TFIIH complex when it is part of the general transcription factor TFIIH. [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]"}
{"concept_id": "C2263046", "aliases": ["core TFIIH complex", "transcription factor TFIIH core complex location", "core TFIIH complex location", "SSL2-core TFIIH complex location", "SSL2-core TFIIH complex"], "types": ["T026"], "canonical_name": "transcription factor TFIIH core complex", "definition": "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD. [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]"}
{"concept_id": "C2263047", "aliases": ["core TFIIH complex portion of NEF3 complex location", "SSL2-core TFIIH complex portion of NEF3 complex", "SSL2-core TFIIH complex portion of NEF3 complex location"], "types": ["T026"], "canonical_name": "core TFIIH complex portion of NEF3 complex", "definition": "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]"}
{"concept_id": "C2263051", "aliases": ["MIS12/MIND type complex location"], "types": ["T026"], "canonical_name": "MIS12/MIND type complex", "definition": "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1. [GOC:krc, PMID:14633972, PMID:16585270]"}
{"concept_id": "C2263052", "aliases": ["Mis12 complex location"], "types": ["T026"], "canonical_name": "Mis12 complex"}
{"concept_id": "C2263053", "aliases": ["THO complex part of TREX complex", "THO complex part of TREX complex location", "THO complex part of transcription export complex location"], "types": ["T026"], "canonical_name": "THO complex part of transcription export complex", "definition": "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits. [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]"}
{"concept_id": "C2263054", "aliases": ["nucleoplasmic THO complex location"], "types": ["T026"], "canonical_name": "nucleoplasmic THO complex", "definition": "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits. [GOC:krc, GOC:se, PMID:11060033, PMID:11979277, PMID:16983072]"}
{"concept_id": "C2263055", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:curators, PMID:10690410]"}
{"concept_id": "C2263056", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage at A2"}
{"concept_id": "C2263057", "aliases": ["cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"], "types": ["T045"], "canonical_name": "cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:curators, PMID:10690410]"}
{"concept_id": "C2263058", "aliases": [], "types": ["T045"], "canonical_name": "cleavage at C2"}
{"concept_id": "C2263059", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)", "definition": "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. [GOC:curators]"}
{"concept_id": "C2263060", "aliases": [], "types": ["T045"], "canonical_name": "cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species. [GOC:curators]"}
{"concept_id": "C2263061", "aliases": [], "types": ["T045"], "canonical_name": "rRNA 2'-O-methylation", "definition": "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis. [GOC:curators, ISBN:1555811337]"}
{"concept_id": "C2263062", "aliases": ["snoRNA guided rRNA 2'-O-ribose methylation"], "types": ["T045"], "canonical_name": "snoRNA guided rRNA 2'-O-methylation", "definition": "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation. [GOC:curators, ISBN:1555811337]"}
{"concept_id": "C2263063", "aliases": [], "types": ["T045"], "canonical_name": "enzyme-directed rRNA 2'-O-methylation", "definition": "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA. [GOC:curators, ISBN:1555811337]"}
{"concept_id": "C2263064", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA guided rRNA pseudouridine synthesis", "definition": "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation. [GOC:curators, ISBN:1555811337]"}
{"concept_id": "C2263065", "aliases": [], "types": ["T045"], "canonical_name": "enzyme-directed rRNA pseudouridine synthesis", "definition": "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA. [GOC:curators, ISBN:1555811337]"}
{"concept_id": "C2263067", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)", "definition": "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. [GOC:curators]"}
{"concept_id": "C2263068", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)", "definition": "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. [GOC:curators]"}
{"concept_id": "C2263069", "aliases": ["exonucleolytic trimming during rRNA processing"], "types": ["T045"], "canonical_name": "exonucleolytic trimming involved in rRNA processing", "definition": "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule. [GOC:curators]"}
{"concept_id": "C2263070", "aliases": [], "types": ["T045"], "canonical_name": "maturation of 5.8S rRNA", "definition": "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. [GOC:curators]"}
{"concept_id": "C2263071", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. [GOC:krc, PMID:10690410]"}
{"concept_id": "C2263072", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage at site D"}
{"concept_id": "C2263073", "aliases": [], "types": ["T045"], "canonical_name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2263074", "aliases": [], "types": ["T045"], "canonical_name": "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2263075", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs. [GOC:krc, PMID:10690410]"}
{"concept_id": "C2263076", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage at A3"}
{"concept_id": "C2263077", "aliases": [], "types": ["T045"], "canonical_name": "exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. [GOC:krc, PMID:10690410]"}
{"concept_id": "C2263078", "aliases": [], "types": ["T045"], "canonical_name": "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:curators, PMID:10690410]"}
{"concept_id": "C2263079", "aliases": [], "types": ["T045"], "canonical_name": "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. [GOC:krc, PMID:10690410]"}
{"concept_id": "C2263080", "aliases": [], "types": ["T045"], "canonical_name": "generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:krc, PMID:10690410]"}
{"concept_id": "C2263081", "aliases": ["complement component C1 complex location"], "types": ["T026"], "canonical_name": "complement component C1 complex", "definition": "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C2263082", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud scar", "definition": "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age. [GOC:rn, PMID:14600225, PMID:2005820]"}
{"concept_id": "C2263083", "aliases": ["holo TFIIH complex location", "transcription factor TFIIH holo complex location", "holo TFIIH complex"], "types": ["T026"], "canonical_name": "transcription factor TFIIH holo complex", "definition": "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]"}
{"concept_id": "C2263084", "aliases": ["mitochondrial permeability transition pore complex", "mitochondrial PT pore complex", "mitochondrial permeability transition pore complex location", "PTPC", "MPTP complex", "MPTP complex location"], "types": ["T026"], "definition": "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D). [PMID:10393078]", "canonical_name": "mitochondrial PT pore complex location"}
{"concept_id": "C2263086", "aliases": ["nuclear cap binding complex location", "nuclear cap binding complex"], "types": ["T026"], "definition": "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. [PMID:16043498]", "canonical_name": "CBC"}
{"concept_id": "C2263087", "aliases": ["mRNA cap binding complex", "mRNA cap binding complex location"], "types": ["T026"], "canonical_name": "mRNA cap binding complex", "definition": "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. [GOC:jid]"}
{"concept_id": "C2263088", "aliases": [], "types": ["T026"], "canonical_name": "inner endospore membrane"}
{"concept_id": "C2263089", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud", "definition": "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated. [GOC:sgd_curators]"}
{"concept_id": "C2263090", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud tip", "definition": "The end of a cellular bud distal to the site of attachment to the mother cell. [GOC:mah]"}
{"concept_id": "C2263091", "aliases": [], "types": ["T026"], "canonical_name": "cellular bud neck", "definition": "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. [GOC:mah]"}
{"concept_id": "C2263093", "aliases": ["arginine-specific carbamoyl phosphate synthetase complex location"], "types": ["T026"], "canonical_name": "arginine-specific carbamoyl phosphate synthetase complex"}
{"concept_id": "C2263094", "aliases": ["carbamoyl-phosphate synthase arginine-specific complex location"], "types": ["T026"], "canonical_name": "carbamoyl-phosphate synthase arginine-specific complex"}
{"concept_id": "C2263096", "aliases": ["cyclic-nucleotide phosphodiesterase complex location"], "types": ["T026"], "canonical_name": "cyclic-nucleotide phosphodiesterase complex", "definition": "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide. [EC:3.1.4.-]"}
{"concept_id": "C2263097", "aliases": ["serine-pyruvate aminotransferase complex location"], "types": ["T026"], "canonical_name": "serine-pyruvate aminotransferase complex", "definition": "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate. [EC:2.6.1.51]"}
{"concept_id": "C2263099", "aliases": ["substituted mannan metabolism"], "types": ["T043"], "canonical_name": "substituted mannan metabolic process", "definition": "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units. [GOC:tair_curators]"}
{"concept_id": "C2263100", "aliases": [], "types": ["T044"], "canonical_name": "metabolic energy generation"}
{"concept_id": "C2263105", "aliases": [], "types": ["T045"], "canonical_name": "establishment of heterochromatic silencing"}
{"concept_id": "C2263110", "aliases": [], "types": ["T045"], "canonical_name": "tRNA editing"}
{"concept_id": "C2263111", "aliases": [], "types": ["T045"], "canonical_name": "natural nonsense suppression"}
{"concept_id": "C2263112", "aliases": ["protein modification", "protein modification process", "process resulting in protein modification"], "types": ["T044"], "definition": "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl]", "canonical_name": "cellular protein modification process"}
{"concept_id": "C2263115", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein kinase activity"}
{"concept_id": "C2263117", "aliases": [], "types": ["T044"], "canonical_name": "N-glycan metabolism"}
{"concept_id": "C2263124", "aliases": [], "types": ["T044"], "canonical_name": "activation of tryptophan 5-monooxygenase activity", "definition": "The process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C2263125", "aliases": [], "types": ["T044"], "canonical_name": "vacuolar protein processing", "definition": "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes. [GOC:mah]"}
{"concept_id": "C2263126", "aliases": ["unsaturated fatty acid formation", "unsaturated fatty acid biosynthesis", "unsaturated fatty acid synthesis", "unsaturated fatty acid anabolism"], "types": ["T044"], "canonical_name": "unsaturated fatty acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782]"}
{"concept_id": "C2263127", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid metabolic process"}
{"concept_id": "C2263128", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid metabolism"}
{"concept_id": "C2263129", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum cofactor biosynthetic process"}
{"concept_id": "C2263133", "aliases": [], "types": ["T043"], "canonical_name": "cellular ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of ions at the level of a cell. [GOC:mah]"}
{"concept_id": "C2263134", "aliases": [], "types": ["T043"], "canonical_name": "cellular calcium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. [GOC:ceb, GOC:mah]"}
{"concept_id": "C2263135", "aliases": [], "types": ["T043"], "canonical_name": "cellular cadmium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of cadmium ions at the level of a cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C2263136", "aliases": [], "types": ["T043"], "canonical_name": "cellular cobalt ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of cobalt ions at the level of a cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C2263137", "aliases": [], "types": ["T043"], "canonical_name": "cellular copper ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C2263138", "aliases": [], "types": ["T043"], "canonical_name": "cellular iron ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C2263139", "aliases": [], "types": ["T043"], "canonical_name": "cellular zinc ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C2263140", "aliases": [], "types": ["T043"], "canonical_name": "cellular sodium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. [GOC:ai, GOC:mah]"}
{"concept_id": "C2263144", "aliases": [], "types": ["T044"], "canonical_name": "activation of antibacterial peptide biosynthetic process"}
{"concept_id": "C2263145", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of antibacterial peptide biosynthetic process"}
{"concept_id": "C2263147", "aliases": [], "types": ["T040"], "canonical_name": "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria"}
{"concept_id": "C2263148", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria"}
{"concept_id": "C2263149", "aliases": [], "types": ["T044"], "canonical_name": "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria"}
{"concept_id": "C2263150", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria"}
{"concept_id": "C2263151", "aliases": [], "types": ["T044"], "canonical_name": "activation of antifungal peptide biosynthetic process"}
{"concept_id": "C2263152", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of antifungal peptide biosynthetic process"}
{"concept_id": "C2263156", "aliases": [], "types": ["T045"], "canonical_name": "unfolded protein response, stimulation of target gene transcription"}
{"concept_id": "C2263159", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microtubule depolymerization"}
{"concept_id": "C2263160", "aliases": ["axonemal microtubule stabilization", "negative regulation of microtubule depolymerization in axoneme"], "types": ["T043"], "canonical_name": "negative regulation of axonemal microtubule depolymerization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme. [GOC:dph, GOC:mah]"}
{"concept_id": "C2263161", "aliases": [], "types": ["T043"], "canonical_name": "spindle assembly involved in male meiosis", "definition": "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster. [GOC:mah]"}
{"concept_id": "C2263162", "aliases": ["male meiosis I spindle assembly"], "types": ["T043"], "canonical_name": "spindle assembly involved in male meiosis I", "definition": "The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster. [GOC:mah]"}
{"concept_id": "C2263163", "aliases": [], "types": ["T043"], "canonical_name": "male meiosis II spindle assembly"}
{"concept_id": "C2263164", "aliases": ["female meiotic spindle assembly"], "types": ["T043"], "canonical_name": "spindle assembly involved in female meiosis", "definition": "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. [GOC:mah]"}
{"concept_id": "C2263165", "aliases": ["female meiosis I spindle assembly"], "types": ["T043"], "canonical_name": "spindle assembly involved in female meiosis I", "definition": "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. [GOC:mah]"}
{"concept_id": "C2263166", "aliases": ["female meiosis II spindle assembly"], "types": ["T043"], "canonical_name": "spindle assembly involved in female meiosis II", "definition": "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. [GOC:mah]"}
{"concept_id": "C2263175", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription involved in exit from mitosis", "definition": "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. [GOC:dph, GOC:isa_complete, GOC:tb]"}
{"concept_id": "C2263176", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription involved in exit from mitosis, from RNA polymerase I promoter", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. [GOC:dph, GOC:tb]"}
{"concept_id": "C2263177", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. [GOC:dph, GOC:tb]"}
{"concept_id": "C2263178", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription involved in exit from mitosis, from RNA polymerase III promoter", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. [GOC:dph, GOC:tb]"}
{"concept_id": "C2263179", "aliases": ["signal transduction involved in mitotic cell cycle checkpoint", "mitotic cell cycle checkpoint"], "types": ["T043"], "canonical_name": "mitotic cell cycle checkpoint signaling", "definition": "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. [GOC:mtg_cell_cycle]"}
{"concept_id": "C2263180", "aliases": ["mitotic cell cycle spindle assembly checkpoint", "signal transduction involved in mitotic cell cycle spindle assembly checkpoint", "mitotic checkpoint", "mitotic spindle assembly checkpoint", "mitotic spindle assembly checkpoint signalling", "signal transduction involved in mitotic spindle assembly checkpoint"], "types": ["T043"], "definition": "A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. [GOC:mtg_cell_cycle, PMID:12360190]", "canonical_name": "mitotic spindle assembly checkpoint signaling"}
{"concept_id": "C2263181", "aliases": ["mitotic cell cycle G2/M transition DNA damage checkpoint", "signal transduction involved in mitotic G2 DNA damage checkpoint", "signal transduction involved in mitotic G2/M transition DNA damage checkpoint", "mitotic G2 DNA damage checkpoint", "G2/M transition DNA damage checkpoint", "signal transduction involved in G2/M transition DNA damage checkpoint", "signal transduction involved in G2 DNA damage checkpoint"], "types": ["T045"], "canonical_name": "mitotic G2 DNA damage checkpoint signaling", "definition": "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. [GOC:mtg_cell_cycle, PMID:16299494]"}
{"concept_id": "C2263186", "aliases": [], "types": ["T043"], "canonical_name": "activation of transmembrane receptor protein tyrosine kinase activity", "definition": "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C2263187", "aliases": [], "types": ["T043"], "canonical_name": "transmembrane receptor protein tyrosine kinase activation"}
{"concept_id": "C2263188", "aliases": [], "types": ["T043"], "canonical_name": "transmembrane receptor protein tyrosine kinase dimerization"}
{"concept_id": "C2263190", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of epidermal growth factor receptor activity"}
{"concept_id": "C2263192", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adenylate cyclase activity"}
{"concept_id": "C2263194", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription of Notch receptor target", "definition": "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain. [PMID:12651094]"}
{"concept_id": "C2263195", "aliases": ["Wnt receptor signaling pathway, calcium modulating pathway", "Wnt-activated signaling pathway, calcium modulating pathway"], "types": ["T044"], "canonical_name": "Wnt signaling pathway, calcium modulating pathway", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397]"}
{"concept_id": "C2263199", "aliases": [], "types": ["T040"], "canonical_name": "gamete generation", "definition": "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. [GOC:ems, GOC:mtg_sensu]"}
{"concept_id": "C2263201", "aliases": [], "types": ["T043"], "canonical_name": "germarium-derived oocyte fate determination", "definition": "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C2263203", "aliases": ["eggshell chorion formation"], "types": ["T042"], "canonical_name": "eggshell chorion assembly", "definition": "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell. [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]"}
{"concept_id": "C2263204", "aliases": [], "types": ["T045"], "canonical_name": "eggshell chorion gene amplification", "definition": "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster. [GOC:mtg_sensu, PMID:11157771]"}
{"concept_id": "C2263209", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of oskar mRNA translation"}
{"concept_id": "C2263224", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of neuroblast proliferation"}
{"concept_id": "C2263226", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration, open tracheal system", "definition": "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster. [GOC:bf, GOC:mtg_sensu]"}
{"concept_id": "C2263227", "aliases": [], "types": ["T042"], "canonical_name": "larval salivary gland boundary specification", "definition": "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. [GOC:tb, PMID:11598957]"}
{"concept_id": "C2263228", "aliases": [], "types": ["T042"], "canonical_name": "adult salivary gland boundary specification", "definition": "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. [GOC:tb, PMID:11598957]"}
{"concept_id": "C2263229", "aliases": [], "types": ["T039"], "canonical_name": "cardiac development"}
{"concept_id": "C2263230", "aliases": [], "types": ["T042"], "canonical_name": "adult cardiac development"}
{"concept_id": "C2263232", "aliases": [], "types": ["T039"], "canonical_name": "carrying of young"}
{"concept_id": "C2263233", "aliases": [], "types": ["T043"], "canonical_name": "body fluid secretion", "definition": "The controlled release of a fluid by a cell or tissue in an animal. [GOC:ai, GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2263234", "aliases": [], "types": ["T042"], "canonical_name": "chitin-based cuticle tanning"}
{"concept_id": "C2263236", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of female receptivity"}
{"concept_id": "C2263238", "aliases": ["maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded", "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded"], "types": ["T040"], "canonical_name": "maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded", "definition": "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line. [GOC:mtg_sensu, ISBN:0879694238]"}
{"concept_id": "C2263246", "aliases": [], "types": ["T044"], "canonical_name": "blood group H alpha-2-fucosyltransferase activity"}
{"concept_id": "C2263247", "aliases": [], "types": ["T044"], "canonical_name": "blood-group substance H-dependent fucosyltransferase activity"}
{"concept_id": "C2263270", "aliases": ["L-histidine:2-oxoglutarate aminotransferase activity", "histidine transaminase activity", "histidine-2-oxoglutarate aminotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate. [EC:2.6.1.38, RHEA:16565]", "canonical_name": "histidine aminotransferase activity"}
{"concept_id": "C2263308", "aliases": ["complex III (mitochondrial electron transport) activity"], "types": ["T044"], "canonical_name": "mitochondrial electron transport complex III"}
{"concept_id": "C2263323", "aliases": [], "types": ["T044"], "canonical_name": "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]"}
{"concept_id": "C2263332", "aliases": [], "types": ["T044"], "canonical_name": "C-esterase (in animal tissues)"}
{"concept_id": "C2263333", "aliases": [], "types": ["T044"], "canonical_name": "chloroesterase"}
{"concept_id": "C2263334", "aliases": [], "types": ["T044"], "canonical_name": "citrus acetylesterase"}
{"concept_id": "C2263335", "aliases": [], "types": ["T044"], "canonical_name": "p-nitrophenyl acetate esterase"}
{"concept_id": "C2263363", "aliases": [], "types": ["T044"], "canonical_name": "complex 1 dehydrogenase activity"}
{"concept_id": "C2263364", "aliases": [], "types": ["T044"], "canonical_name": "complex I (electron transport chain) activity"}
{"concept_id": "C2263365", "aliases": ["mitochondrial electron transport complex 1 activity", "mitochondrial electron transport complex I activity"], "types": ["T044"], "canonical_name": "complex I (mitochondrial electron transport) activity"}
{"concept_id": "C2263366", "aliases": [], "types": ["T044"], "canonical_name": "complex I (NADH:Q1 oxidoreductase) activity"}
{"concept_id": "C2263370", "aliases": [], "types": ["T044"], "canonical_name": "electron transfer complex I activity"}
{"concept_id": "C2263380", "aliases": [], "types": ["T044"], "canonical_name": "NADH:ubiquinone oxidoreductase complex activity"}
{"concept_id": "C2263383", "aliases": [], "types": ["T045"], "canonical_name": "processing at B2"}
{"concept_id": "C2263384", "aliases": ["cleavage during rRNA processing"], "types": ["T045"], "canonical_name": "cleavage involved in rRNA processing", "definition": "Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. [GOC:curators]"}
{"concept_id": "C2263385", "aliases": [], "types": ["T045"], "canonical_name": "maturation of LSU-rRNA", "definition": "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. [GOC:curators]"}
{"concept_id": "C2263386", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events. [GOC:krc, PMID:10690410]"}
{"concept_id": "C2263387", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. [GOC:curators, PMID:10690410]"}
{"concept_id": "C2263388", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage at A1"}
{"concept_id": "C2263389", "aliases": [], "types": ["T045"], "canonical_name": "maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)", "definition": "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2263390", "aliases": [], "types": ["T045"], "canonical_name": "maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)", "definition": "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2263391", "aliases": [], "types": ["T045"], "canonical_name": "maturation of 2S rRNA", "definition": "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule. [GOC:curators]"}
{"concept_id": "C2263392", "aliases": [], "types": ["T045"], "canonical_name": "maturation of 4.5S rRNA", "definition": "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule. [GOC:curators]"}
{"concept_id": "C2263393", "aliases": [], "types": ["T045"], "canonical_name": "generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:curators, PMID:10690410]"}
{"concept_id": "C2263394", "aliases": [], "types": ["T045"], "canonical_name": "processing at C1"}
{"concept_id": "C2263395", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage during rRNA processing"}
{"concept_id": "C2263396", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae. [GOC:curators, PMID:10690410]"}
{"concept_id": "C2263397", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. [GOC:curators, PMID:10690410, PMID:15282326]"}
{"concept_id": "C2263398", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage at A-prime"}
{"concept_id": "C2263399", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage at A0"}
{"concept_id": "C2263400", "aliases": [], "types": ["T045"], "canonical_name": "maturation of 5S rRNA", "definition": "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule. [GOC:curators]"}
{"concept_id": "C2263401", "aliases": [], "types": ["T045"], "canonical_name": "maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "definition": "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2263402", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species. [GOC:curators]"}
{"concept_id": "C2263403", "aliases": [], "types": ["T045"], "canonical_name": "cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2263404", "aliases": [], "types": ["T045"], "canonical_name": "cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:curators, PMID:768488]"}
{"concept_id": "C2263405", "aliases": [], "types": ["T045"], "canonical_name": "cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)", "definition": "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:curators, PMID:768488]"}
{"concept_id": "C2263406", "aliases": [], "types": ["T045"], "canonical_name": "maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)", "definition": "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2263407", "aliases": [], "types": ["T045"], "canonical_name": "maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)", "definition": "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2263408", "aliases": [], "types": ["T045"], "canonical_name": "maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)", "definition": "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. [GOC:curators]"}
{"concept_id": "C2263409", "aliases": ["snoRNP assembly"], "types": ["T044"], "canonical_name": "small nucleolar ribonucleoprotein complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex. [GOC:krc]"}
{"concept_id": "C2263410", "aliases": ["box C/D small nucleolar ribonucleoprotein complex assembly"], "types": ["T045"], "canonical_name": "box C/D snoRNP assembly", "definition": "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex. [GOC:krc]"}
{"concept_id": "C2263411", "aliases": ["box H/ACA small nucleolar ribonucleoprotein complex assembly"], "types": ["T044"], "canonical_name": "box H/ACA snoRNP assembly", "definition": "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex. [GOC:krc, PMID:12515383]"}
{"concept_id": "C2263412", "aliases": [], "types": ["T045"], "canonical_name": "box C/D snoRNA 3'-end processing"}
{"concept_id": "C2263413", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA snoRNA 3'-end processing"}
{"concept_id": "C2263414", "aliases": [], "types": ["T045"], "canonical_name": "base pairing with DNA"}
{"concept_id": "C2263415", "aliases": [], "types": ["T045"], "canonical_name": "base pairing with RNA"}
{"concept_id": "C2263416", "aliases": [], "types": ["T045"], "canonical_name": "base pairing with mRNA"}
{"concept_id": "C2263428", "aliases": [], "types": ["T044"], "canonical_name": "diacetyl (acetoin) reductase activity"}
{"concept_id": "C2263429", "aliases": [], "types": ["T044"], "canonical_name": "methyltransferase II"}
{"concept_id": "C2263432", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylethanolamine methyltransferase I"}
{"concept_id": "C2263442", "aliases": [], "types": ["T044"], "canonical_name": "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)"}
{"concept_id": "C2263444", "aliases": [], "types": ["T044"], "canonical_name": "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)"}
{"concept_id": "C2263452", "aliases": ["repressor ecdysone receptor complex location"], "types": ["T026"], "canonical_name": "repressor ecdysone receptor complex", "definition": "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes. [PMID:10488333]"}
{"concept_id": "C2263453", "aliases": ["activator ecdysone receptor complex location"], "types": ["T026"], "canonical_name": "activator ecdysone receptor complex", "definition": "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes. [PMID:10488333]"}
{"concept_id": "C2263474", "aliases": [], "types": ["T044"], "canonical_name": "5'-adenylic phosphatase"}
{"concept_id": "C2263477", "aliases": [], "types": ["T044"], "canonical_name": "adenosine 5'-phosphatase"}
{"concept_id": "C2263478", "aliases": ["AMP phosphatase"], "types": ["T044"], "canonical_name": "adenosine monophosphatase"}
{"concept_id": "C2263479", "aliases": [], "types": ["T044"], "canonical_name": "snake venom 5'-nucleotidase"}
{"concept_id": "C2263480", "aliases": [], "types": ["T044"], "canonical_name": "thimidine monophosphate nucleotidase"}
{"concept_id": "C2263481", "aliases": [], "types": ["T044"], "canonical_name": "uridine 5'-nucleotidase"}
{"concept_id": "C2263501", "aliases": [], "types": ["T044"], "canonical_name": "importin-alpha binding"}
{"concept_id": "C2263505", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell proliferation"}
{"concept_id": "C2263508", "aliases": [], "types": ["T044"], "canonical_name": "daf-2 receptor signaling pathway"}
{"concept_id": "C2263509", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid anabolism"}
{"concept_id": "C2263510", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid biosynthesis"}
{"concept_id": "C2263511", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid biosynthetic process"}
{"concept_id": "C2263512", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid formation"}
{"concept_id": "C2263513", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid synthesis"}
{"concept_id": "C2263514", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid breakdown"}
{"concept_id": "C2263515", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid catabolic process"}
{"concept_id": "C2263516", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid catabolism"}
{"concept_id": "C2263517", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenoid degradation"}
{"concept_id": "C2263518", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated anion channel activity", "definition": "Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:vw, ISBN:0815340729]"}
{"concept_id": "C2263519", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of vitelline membrane", "definition": "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:sensu]"}
{"concept_id": "C2263520", "aliases": [], "types": ["T044"], "canonical_name": "protein transmembrane transporter activity", "definition": "Enables the transfer of a protein from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C2263521", "aliases": ["transmembrane cation transporter activity"], "types": ["T044"], "canonical_name": "cation transmembrane transporter activity", "definition": "Enables the transfer of cation from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2263528", "aliases": [], "types": ["T046"], "canonical_name": "inhibition of antimicrobial humoral response"}
{"concept_id": "C2263529", "aliases": [], "types": ["T045"], "canonical_name": "ATP:DNA-directed RNA polymerase phosphotransferase activity"}
{"concept_id": "C2263534", "aliases": [], "types": ["T044"], "canonical_name": "TANK-binding kinase 1 activity"}
{"concept_id": "C2263535", "aliases": [], "types": ["T044"], "canonical_name": "C27-side chain cleavage enzyme"}
{"concept_id": "C2263539", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol side-chain cleavage enzyme activity"}
{"concept_id": "C2263540", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol side-chain-cleaving enzyme activity"}
{"concept_id": "C2263541", "aliases": ["cytochrome p450(scc) activity"], "types": ["T044"], "canonical_name": "cytochrome P-450(scc) activity"}
{"concept_id": "C2263543", "aliases": [], "types": ["T044"], "canonical_name": "enzymes, cholesterol side-chain-cleaving"}
{"concept_id": "C2263544", "aliases": [], "types": ["T044"], "canonical_name": "steroid 20-22 desmolase activity"}
{"concept_id": "C2263545", "aliases": [], "types": ["T044"], "canonical_name": "steroid 20-22-lyase activity"}
{"concept_id": "C2263546", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 51 activity"}
{"concept_id": "C2263548", "aliases": [], "types": ["T044"], "canonical_name": "lanosterol 14-demethylase activity"}
{"concept_id": "C2263549", "aliases": [], "types": ["T044"], "canonical_name": "obtusufoliol 14-demethylase activity"}
{"concept_id": "C2263553", "aliases": ["8-oxo-7,8-dihydroguanosine triphosphatase activity", "7,8-dihydro-8-oxoguanine-triphosphatase activity", "8-oxo-7,8-dihydroguanine triphosphatase activity", "8-oxo-GTPase activity"], "types": ["T044"], "canonical_name": "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity", "definition": "Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. [PMID:15878881, RHEA:60032]"}
{"concept_id": "C2263556", "aliases": ["N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity", "long-chain acylglutamate amidase activity", "long-chain fatty acyl-glutamate deacylase activity", "long-chain aminoacylase activity", "long-chain-fatty-acyl-glutamate deacylase activity"], "types": ["T044"], "canonical_name": "long-chain fatty-acyl-glutamate deacylase activity", "definition": "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate. [EC:3.5.1.55]"}
{"concept_id": "C2263557", "aliases": [], "types": ["T044"], "canonical_name": "amygdalase activity"}
{"concept_id": "C2263564", "aliases": [], "types": ["T044"], "canonical_name": "cellobiase activity"}
{"concept_id": "C2263565", "aliases": [], "types": ["T044"], "canonical_name": "elaterase activity"}
{"concept_id": "C2263566", "aliases": [], "types": ["T044"], "canonical_name": "emulsin"}
{"concept_id": "C2263567", "aliases": [], "types": ["T044"], "canonical_name": "gentiobiase activity"}
{"concept_id": "C2263568", "aliases": [], "types": ["T044"], "canonical_name": "gentobiase activity"}
{"concept_id": "C2263569", "aliases": [], "types": ["T044"], "canonical_name": "limarase activity"}
{"concept_id": "C2263571", "aliases": [], "types": ["T044"], "canonical_name": "primeverosidase activity"}
{"concept_id": "C2263572", "aliases": [], "types": ["T044"], "canonical_name": "salicilinase activity"}
{"concept_id": "C2263577", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein fucosyltransferase activity"}
{"concept_id": "C2263644", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV"}
{"concept_id": "C2263655", "aliases": [], "types": ["T044"], "canonical_name": "alpha-galactosidase B activity"}
{"concept_id": "C2263659", "aliases": ["poly-N-acetyllactosamine extension enzyme activity"], "types": ["T044"], "canonical_name": "poly-N-acetyllactosamine extension enzyme activity"}
{"concept_id": "C2263661", "aliases": ["uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase"], "types": ["T044"], "canonical_name": "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase"}
{"concept_id": "C2263663", "aliases": [], "types": ["T044"], "canonical_name": "easily solubilized mitochondrial carnitine palmitoyltransferase"}
{"concept_id": "C2263666", "aliases": [], "types": ["T044"], "canonical_name": "overt mitochondrial carnitine palmitoyltransferase"}
{"concept_id": "C2263691", "aliases": [], "types": ["T044"], "canonical_name": "glycogenin activity"}
{"concept_id": "C2263692", "aliases": [], "types": ["T044"], "canonical_name": "priming glucosyltransferase activity"}
{"concept_id": "C2263695", "aliases": [], "types": ["T044"], "canonical_name": "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase"}
{"concept_id": "C2263699", "aliases": [], "types": ["T044"], "canonical_name": "isoform/isozyme 1 (3-OST-1, HS3ST1)"}
{"concept_id": "C2263701", "aliases": [], "types": ["T044"], "canonical_name": "histone protein methylase I"}
{"concept_id": "C2263703", "aliases": ["protein methylase I activity"], "types": ["T044"], "canonical_name": "protein methylase I activity"}
{"concept_id": "C2263709", "aliases": ["p-diphenol:oxygen oxidoreductase activity", "benzenediol:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "hydroquinone:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O. [EC:1.10.3.2]"}
{"concept_id": "C2263736", "aliases": ["IAG-nucleoside hydrolase activity", "IAG-NH activity"], "types": ["T044"], "canonical_name": "inosine-adenosine-guanosine preferring nucleoside hydrolase activity"}
{"concept_id": "C2263739", "aliases": [], "types": ["T044"], "canonical_name": "nucleosidase activity"}
{"concept_id": "C2263740", "aliases": [], "types": ["T044"], "canonical_name": "nucleosidase g activity"}
{"concept_id": "C2263741", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside hydrolase activity"}
{"concept_id": "C2263752", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxamine kinase activity"}
{"concept_id": "C2263753", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxine kinase activity"}
{"concept_id": "C2263754", "aliases": [], "types": ["T044"], "canonical_name": "vitamin B(6) kinase activity"}
{"concept_id": "C2263755", "aliases": [], "types": ["T044"], "canonical_name": "vitamin B6 kinase activity"}
{"concept_id": "C2263757", "aliases": [], "types": ["T045"], "canonical_name": "guanine insertion enzyme activity"}
{"concept_id": "C2263774", "aliases": [], "types": ["T044"], "canonical_name": "arsenite secondary active transmembrane transporter activity", "definition": "Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:jl]"}
{"concept_id": "C2263782", "aliases": [], "types": ["T044"], "canonical_name": "monoamine transmembrane transporter activity", "definition": "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2263783", "aliases": [], "types": ["T044"], "canonical_name": "secondary active organic cation transmembrane transporter activity", "definition": "Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. [GOC:curators]"}
{"concept_id": "C2263784", "aliases": [], "types": ["T044"], "canonical_name": "organic anion transmembrane transporter activity", "definition": "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai]"}
{"concept_id": "C2263785", "aliases": [], "types": ["T044"], "canonical_name": "sodium-dependent multivitamin transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate. [TC:2.A.21.5.2]"}
{"concept_id": "C2263786", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine transmembrane transporter activity"}
{"concept_id": "C2263801", "aliases": [], "types": ["T045"], "canonical_name": "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]"}
{"concept_id": "C2263803", "aliases": [], "types": ["T045"], "canonical_name": "Fpg protein"}
{"concept_id": "C2263810", "aliases": [], "types": ["T044"], "canonical_name": "H+-transporting ATPase"}
{"concept_id": "C2263819", "aliases": [], "types": ["T044"], "canonical_name": "sodium transport ATPase activity"}
{"concept_id": "C2263821", "aliases": ["sodium-translocating P-type ATPase activity", "sodium-exporting ATPase activity, phosphorylative mechanism", "sodium transmembrane transporter activity, phosphorylative mechanism", "sodium exporting ATPase activity, phosphorylative mechanism"], "types": ["T044"], "canonical_name": "P-type sodium transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism. [PMID:9224683]"}
{"concept_id": "C2263832", "aliases": [], "types": ["T044"], "canonical_name": "potassium-importing ATPase activity"}
{"concept_id": "C2263836", "aliases": [], "types": ["T044"], "canonical_name": "MDR protein"}
{"concept_id": "C2263837", "aliases": [], "types": ["T044"], "canonical_name": "PDR protein"}
{"concept_id": "C2263838", "aliases": [], "types": ["T044"], "canonical_name": "pleiotropic-drug-resistance protein"}
{"concept_id": "C2263843", "aliases": [], "types": ["T044"], "canonical_name": "katanin activity"}
{"concept_id": "C2263846", "aliases": [], "types": ["T043"], "canonical_name": "amphotelic attachment"}
{"concept_id": "C2263854", "aliases": [], "types": ["T044"], "canonical_name": "DHAP-AT"}
{"concept_id": "C2263855", "aliases": [], "types": ["T044"], "canonical_name": "plasmalogen biosynthetic process"}
{"concept_id": "C2264002", "aliases": [], "types": ["T044"], "canonical_name": "HcaA1A2CD"}
{"concept_id": "C2264007", "aliases": [], "types": ["T044"], "canonical_name": "enzyme X activity"}
{"concept_id": "C2264030", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"}
{"concept_id": "C2264053", "aliases": [], "types": ["T044"], "canonical_name": "phospho-beta-glucosidase A"}
{"concept_id": "C2264056", "aliases": [], "types": ["T044"], "canonical_name": "6-phytase (name based on 1L-numbering system and not 1D-numbering)"}
{"concept_id": "C2264060", "aliases": [], "types": ["T044"], "canonical_name": "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity"}
{"concept_id": "C2264092", "aliases": ["DNA glycosidase I activity"], "types": ["T045"], "canonical_name": "DNA glycosidase I activity"}
{"concept_id": "C2264096", "aliases": [], "types": ["T044"], "canonical_name": "sulfate starvation-induced protein 6 activity"}
{"concept_id": "C2264097", "aliases": [], "types": ["T044"], "canonical_name": "(p)ppGpp synthetase I"}
{"concept_id": "C2264098", "aliases": [], "types": ["T044"], "canonical_name": "(p)ppGpp synthetase II"}
{"concept_id": "C2264104", "aliases": [], "types": ["T044"], "canonical_name": "stringent factor activity"}
{"concept_id": "C2264114", "aliases": [], "types": ["T044"], "canonical_name": "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]"}
{"concept_id": "C2264135", "aliases": [], "types": ["T044"], "canonical_name": "threonine 3-dehydrogenase activity"}
{"concept_id": "C2264145", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylmuramoyl-L-alanine amidase type I"}
{"concept_id": "C2264146", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylmuramoyl-L-alanine amidase type II"}
{"concept_id": "C2264168", "aliases": [], "types": ["T044"], "canonical_name": "transhydrogenase activity"}
{"concept_id": "C2264188", "aliases": [], "types": ["T044"], "canonical_name": "MurA transferase activity"}
{"concept_id": "C2264204", "aliases": [], "types": ["T044"], "canonical_name": "MurB reductase"}
{"concept_id": "C2264212", "aliases": [], "types": ["T044"], "canonical_name": "alanine-adding enzyme activity"}
{"concept_id": "C2264213", "aliases": [], "types": ["T044"], "canonical_name": "L-Ala ligase activity"}
{"concept_id": "C2264214", "aliases": [], "types": ["T044"], "canonical_name": "L-alanine-adding enzyme activity"}
{"concept_id": "C2264215", "aliases": [], "types": ["T044"], "canonical_name": "MurC synthetase activity"}
{"concept_id": "C2264224", "aliases": [], "types": ["T044"], "canonical_name": "D-glutamate ligase activity"}
{"concept_id": "C2264225", "aliases": [], "types": ["T044"], "canonical_name": "D-glutamate-adding enzyme activity"}
{"concept_id": "C2264248", "aliases": [], "types": ["T044"], "canonical_name": "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)"}
{"concept_id": "C2264258", "aliases": [], "types": ["T045"], "canonical_name": "uridyl removing enzyme"}
{"concept_id": "C2264259", "aliases": ["uridylyl removing enzyme activity"], "types": ["T044"], "canonical_name": "uridylyl removing enzyme activity"}
{"concept_id": "C2264275", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylornithinase activity"}
{"concept_id": "C2264321", "aliases": [], "types": ["T044"], "canonical_name": "D-arabinose isomerase activity"}
{"concept_id": "C2264348", "aliases": [], "types": ["T044"], "canonical_name": "beta-lactamase A, B, C"}
{"concept_id": "C2264349", "aliases": [], "types": ["T044"], "canonical_name": "beta-lactamase AME I"}
{"concept_id": "C2264350", "aliases": [], "types": ["T044"], "canonical_name": "beta-lactamase I-III"}
{"concept_id": "C2264353", "aliases": [], "types": ["T044"], "canonical_name": "neutrapen"}
{"concept_id": "C2264356", "aliases": [], "types": ["T044"], "canonical_name": "penicillinase I, II"}
{"concept_id": "C2264371", "aliases": [], "types": ["T044"], "canonical_name": "dinucleosidetetraphosphate (symmetrical)"}
{"concept_id": "C2264379", "aliases": [], "types": ["T044"], "canonical_name": "carbon monoxide oxygenase (cytochrome b-561) activity"}
{"concept_id": "C2264381", "aliases": [], "types": ["T044"], "canonical_name": "carbon monoxide:methylene blue oxidoreductase activity"}
{"concept_id": "C2264393", "aliases": [], "types": ["T044"], "canonical_name": "alkali cellulase activity"}
{"concept_id": "C2264394", "aliases": ["avicelase activity"], "types": ["T044"], "canonical_name": "avicelase activity"}
{"concept_id": "C2264395", "aliases": [], "types": ["T044"], "canonical_name": "beta-1,4-endoglucan hydrolase activity"}
{"concept_id": "C2264396", "aliases": [], "types": ["T044"], "canonical_name": "carboxymethyl cellulase activity"}
{"concept_id": "C2264397", "aliases": [], "types": ["T044"], "canonical_name": "celluase A"}
{"concept_id": "C2264399", "aliases": [], "types": ["T044"], "canonical_name": "cellulase A 3"}
{"concept_id": "C2264400", "aliases": [], "types": ["T044"], "canonical_name": "cellulosin AP"}
{"concept_id": "C2264402", "aliases": [], "types": ["T044"], "canonical_name": "endo-1,4-beta-D-glucanohydrolase activity"}
{"concept_id": "C2264403", "aliases": [], "types": ["T044"], "canonical_name": "endoglucanase activity"}
{"concept_id": "C2264404", "aliases": [], "types": ["T044"], "canonical_name": "endoglucanase D"}
{"concept_id": "C2264405", "aliases": [], "types": ["T044"], "canonical_name": "pancellase SS"}
{"concept_id": "C2264410", "aliases": [], "types": ["T044"], "canonical_name": "choline-cytochrome c reductase activity"}
{"concept_id": "C2264417", "aliases": [], "types": ["T044"], "canonical_name": "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]"}
{"concept_id": "C2264425", "aliases": [], "types": ["T044"], "canonical_name": "aquocob(I)alamin vitamin B12s adenosyltransferase activity"}
{"concept_id": "C2264433", "aliases": ["endonuclease RuvC activity"], "types": ["T045"], "canonical_name": "RuvC endonuclease activity"}
{"concept_id": "C2264434", "aliases": [], "types": ["T045"], "canonical_name": "endonuclease VII activity"}
{"concept_id": "C2264435", "aliases": [], "types": ["T045"], "canonical_name": "endonuclease X3 activity"}
{"concept_id": "C2264437", "aliases": [], "types": ["T045"], "canonical_name": "Holliday junction endonuclease CCE1 activity"}
{"concept_id": "C2264440", "aliases": [], "types": ["T045"], "canonical_name": "Holliday junction-resolving endoribonuclease activity"}
{"concept_id": "C2264441", "aliases": [], "types": ["T045"], "canonical_name": "resolving enzyme CCE1 activity"}
{"concept_id": "C2264442", "aliases": [], "types": ["T045"], "canonical_name": "RusA endonuclease activity"}
{"concept_id": "C2264444", "aliases": ["RusA holliday junction resolvase"], "types": ["T045"], "canonical_name": "RusA Holliday junction resolvase activity"}
{"concept_id": "C2264445", "aliases": ["SpCCe1 holliday junction resolvase"], "types": ["T045"], "canonical_name": "SpCCe1 Holliday junction resolvase activity"}
{"concept_id": "C2264463", "aliases": [], "types": ["T044"], "canonical_name": "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity"}
{"concept_id": "C2264479", "aliases": [], "types": ["T045"], "canonical_name": "endonuclease II"}
{"concept_id": "C2264480", "aliases": ["endonuclease IV"], "types": ["T045"], "canonical_name": "endonuclease IV activity"}
{"concept_id": "C2264481", "aliases": [], "types": ["T045"], "canonical_name": "Escherichia coli endonuclease II"}
{"concept_id": "C2264483", "aliases": [], "types": ["T044"], "canonical_name": "bactoprenyl-diphosphate synthase activity"}
{"concept_id": "C2264500", "aliases": ["dihydrodipicolinic acid reductase activity", "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity", "dihydrodipicolinate reductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+. [EC:1.17.1.8]", "canonical_name": "4-hydroxy-tetrahydrodipicolinate reductase"}
{"concept_id": "C2264506", "aliases": [], "types": ["T044"], "canonical_name": "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]"}
{"concept_id": "C2264541", "aliases": ["E. coli exonuclease I"], "types": ["T045"], "canonical_name": "E. coli exonuclease I activity"}
{"concept_id": "C2264542", "aliases": [], "types": ["T045"], "canonical_name": "Escherichia coli exonuclease I"}
{"concept_id": "C2264543", "aliases": ["E. coli exonuclease III activity", "E. coli exonuclease III"], "types": ["T045"], "canonical_name": "Escherichia coli exonuclease III"}
{"concept_id": "C2264544", "aliases": [], "types": ["T045"], "canonical_name": "endoribonuclease III"}
{"concept_id": "C2264546", "aliases": ["E. coli exonuclease V"], "types": ["T045"], "canonical_name": "E. coli exonuclease V activity"}
{"concept_id": "C2264547", "aliases": [], "types": ["T045"], "canonical_name": "Escherichia coli exonuclease V"}
{"concept_id": "C2264550", "aliases": [], "types": ["T045"], "canonical_name": "gene recBC endoenzyme"}
{"concept_id": "C2264551", "aliases": [], "types": ["T045"], "canonical_name": "gene recBCD enzymes"}
{"concept_id": "C2264553", "aliases": ["E. coli exonuclease VII"], "types": ["T045"], "canonical_name": "E. coli exonuclease VII activity"}
{"concept_id": "C2264555", "aliases": [], "types": ["T045"], "canonical_name": "endodeoxyribonuclease VII"}
{"concept_id": "C2264556", "aliases": [], "types": ["T045"], "canonical_name": "Escherichia coli exonuclease VII"}
{"concept_id": "C2264559", "aliases": [], "types": ["T045"], "canonical_name": "Escherichia coli endodeoxyribonuclease activity"}
{"concept_id": "C2264560", "aliases": [], "types": ["T045"], "canonical_name": "Escherichia coli endodeoxyribonuclease X activity"}
{"concept_id": "C2264563", "aliases": [], "types": ["T045"], "canonical_name": "Escherichia coli exo-RNase II"}
{"concept_id": "C2264564", "aliases": [], "types": ["T045"], "canonical_name": "ribonuclease Q"}
{"concept_id": "C2264608", "aliases": ["2''-aminoglycoside nucleotidyltransferase activity"], "types": ["T044"], "canonical_name": "aminoglycoside 2''-nucleotidyltransferase activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside. [EC:2.7.7.46, GOC:cb]"}
{"concept_id": "C2264609", "aliases": [], "types": ["T044"], "canonical_name": "gentamicin 2''- adenylyltransferase activity"}
{"concept_id": "C2264610", "aliases": [], "types": ["T044"], "canonical_name": "NTP:gentamicin 2''-nucleotidyltransferase activity"}
{"concept_id": "C2264655", "aliases": [], "types": ["T044"], "canonical_name": "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]"}
{"concept_id": "C2264660", "aliases": [], "types": ["T044"], "canonical_name": "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)"}
{"concept_id": "C2264661", "aliases": ["glyceraldehyde phosphate dehydrogenase (NADP)"], "types": ["T044"], "canonical_name": "NADP-glyceraldehyde phosphate dehydrogenase"}
{"concept_id": "C2264671", "aliases": ["NAD-linked glycerol dehydrogenase activity"], "types": ["T044"], "canonical_name": "glycerol dehydrogenase [NAD+] activity", "definition": "Catalysis of the reaction: glycerol + NAD(+) = glycerone + H(+) + NADH. [EC:1.1.1.6, RHEA:13769]"}
{"concept_id": "C2264672", "aliases": [], "types": ["T044"], "canonical_name": "gene hpd protein"}
{"concept_id": "C2264675", "aliases": [], "types": ["T044"], "canonical_name": "IgD-binding protein D"}
{"concept_id": "C2264697", "aliases": [], "types": ["T044"], "canonical_name": "acyl carrier protein synthase activity"}
{"concept_id": "C2264698", "aliases": [], "types": ["T044"], "canonical_name": "acyl carrier protein synthetase activity"}
{"concept_id": "C2264704", "aliases": [], "types": ["T044"], "canonical_name": "holo-ACP synthetase activity"}
{"concept_id": "C2264705", "aliases": [], "types": ["T044"], "canonical_name": "holosynthase activity"}
{"concept_id": "C2264706", "aliases": [], "types": ["T044"], "canonical_name": "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity"}
{"concept_id": "C2264723", "aliases": [], "types": ["T044"], "canonical_name": "gastric H(+)/K(+) ATPase activity"}
{"concept_id": "C2264724", "aliases": [], "types": ["T044"], "canonical_name": "gastric H+/K+ ATPase"}
{"concept_id": "C2264727", "aliases": [], "types": ["T044"], "canonical_name": "[Fe] hydrogenase gamma"}
{"concept_id": "C2264728", "aliases": ["H(2) oxidizing hydrogenase activity"], "types": ["T044"], "canonical_name": "H2 oxidizing hydrogenase"}
{"concept_id": "C2264729", "aliases": [], "types": ["T044"], "canonical_name": "H(2) producing hydrogenase activity"}
{"concept_id": "C2264730", "aliases": [], "types": ["T044"], "canonical_name": "H2 producing hydrogenase"}
{"concept_id": "C2264732", "aliases": [], "types": ["T044"], "canonical_name": "hydrogenase I"}
{"concept_id": "C2264733", "aliases": [], "types": ["T044"], "canonical_name": "hydrogenase II"}
{"concept_id": "C2264734", "aliases": [], "types": ["T044"], "canonical_name": "iron-only hydrogenase activity"}
{"concept_id": "C2264741", "aliases": ["destomic acid ring 7''-O-phosphotransferase activity", "ATP:hygromycin-B 7''-O-phosphotransferase activity"], "types": ["T044"], "canonical_name": "hygromycin-B 7''-O-phosphotransferase activity", "definition": "Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H(+). [EC:2.7.1.119, RHEA:23388]"}
{"concept_id": "C2264743", "aliases": [], "types": ["T044"], "canonical_name": "hygromycin B phosphotransferase activity"}
{"concept_id": "C2264746", "aliases": [], "types": ["T044"], "canonical_name": "inosine-guanosine kinase activity"}
{"concept_id": "C2264763", "aliases": ["L-lactaldehyde:propanediol oxidoreductase activity", "(S)-propane-1,2-diol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "S-lactaldehyde reductase activity", "definition": "Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+. [RHEA:15933]"}
{"concept_id": "C2264764", "aliases": [], "types": ["T044"], "canonical_name": "propanediol oxidoreductase activity"}
{"concept_id": "C2264787", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I"}
{"concept_id": "C2264790", "aliases": ["stearoyl-ACP synthetase activity", "long-chain-fatty-acid-ACP ligase activity", "acyl-acyl carrier protein synthetase", "acyl-acyl-carrier-proteinsynthetase activity", "long-chain fatty acid-[acyl-carrier-protein] ligase activity", "long-chain-fatty-acid-acyl-carrier-protein ligase activity", "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity", "acyl-ACP synthetase activity", "long-chain-fatty-acid-[acyl-carrier-protein] ligase activity", "acyl-acyl-carrier-protein synthetase activity", "acyl-[acyl-carrier-protein] synthetase activity", "long-chain-fatty-acid-[acyl-carrier protein] ligase activity"], "types": ["T044"], "canonical_name": "long-chain fatty acid [acyl-carrier-protein] ligase activity", "definition": "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22. [EC:6.2.1.20]"}
{"concept_id": "C2264818", "aliases": [], "types": ["T044"], "canonical_name": "lytic endotransglycosylase activity", "definition": "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends. [PMID:10964424, PMID:9642199]"}
{"concept_id": "C2264819", "aliases": ["peptidoglycan lytic transglycosylase activity"], "types": ["T044"], "canonical_name": "lytic transglycosylase activity", "definition": "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. [PMID:10964424, PMID:22748813]"}
{"concept_id": "C2264821", "aliases": ["myo-inositol-phosphate phosphohydrolase activity", "myo-inositol phosphatase activity", "myo-inositol-phosphatase activity", "inositol-phosphate phosphatase activity", "inositol phosphatase activity", "myo-inositol monophosphatase activity", "L-myo-inositol-phosphate phosphatase activity"], "types": ["T044"], "canonical_name": "inositol monophosphate phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate. [EC:3.1.3.25]"}
{"concept_id": "C2264822", "aliases": [], "types": ["T044"], "canonical_name": "inositol phosphate phosphatase activity", "definition": "Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. [GOC:ai]"}
{"concept_id": "C2264824", "aliases": ["myo-inositol-1-phosphatase activity", "inositol 1-phosphatase activity", "L-myo-inositol-1-phosphate phosphatase activity", "myo-inositol 1-phosphatase activity"], "types": ["T044"], "canonical_name": "inositol monophosphate 1-phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. [EC:3.1.3.25]"}
{"concept_id": "C2264827", "aliases": ["myo-inositol-1(or 4)-monophosphatase activity", "myo-inositol-1(or 4)-phosphate phosphohydrolase activity"], "types": ["T044"], "canonical_name": "myo-inositol-1(or 4)-monophosphatase activity"}
{"concept_id": "C2264831", "aliases": ["dihydroxynaphthoic acid synthetase activity", "dihydroxynaphthoate synthase activity", "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity", "DHNA synthetase activity"], "types": ["T044"], "canonical_name": "1,4-dihydroxy-2-naphthoyl-CoA synthase activity", "definition": "Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O. [RHEA:26562]"}
{"concept_id": "C2264852", "aliases": [], "types": ["T044"], "canonical_name": "respiratory nitrate reductase activity"}
{"concept_id": "C2264855", "aliases": [], "types": ["T044"], "canonical_name": "assimilatory nitrite reductase activity"}
{"concept_id": "C2264861", "aliases": [], "types": ["T044"], "canonical_name": "nitrite reductase [NAD(P)H2]"}
{"concept_id": "C2264876", "aliases": [], "types": ["T044"], "canonical_name": "novozym 217"}
{"concept_id": "C2264881", "aliases": [], "types": ["T044"], "canonical_name": "penicillin binding protein (3 or 1B) activity"}
{"concept_id": "C2264891", "aliases": [], "types": ["T044"], "canonical_name": "phosphoglycerol transferase activity"}
{"concept_id": "C2264893", "aliases": [], "types": ["T044"], "canonical_name": "MraY transferase activity"}
{"concept_id": "C2264915", "aliases": [], "types": ["T044"], "canonical_name": "sugar--PEP phosphotransferase enzyme I activity"}
{"concept_id": "C2264927", "aliases": [], "types": ["T044"], "canonical_name": "deoxyribomutase activity"}
{"concept_id": "C2264928", "aliases": [], "types": ["T044"], "canonical_name": "deoxyribose phosphomutase activity"}
{"concept_id": "C2264929", "aliases": [], "types": ["T044"], "canonical_name": "phosphodeoxyribomutase activity"}
{"concept_id": "C2264933", "aliases": [], "types": ["T044"], "canonical_name": "phosphopentokinase activity"}
{"concept_id": "C2264949", "aliases": [], "types": ["T044"], "canonical_name": "enzyme IIl4ac"}
{"concept_id": "C2264950", "aliases": [], "types": ["T045"], "canonical_name": "gene bglC RNA formation factors"}
{"concept_id": "C2264951", "aliases": [], "types": ["T044"], "canonical_name": "gene glC proteins"}
{"concept_id": "C2264952", "aliases": [], "types": ["T044"], "canonical_name": "PEP--sugar phosphotransferase enzyme II activity"}
{"concept_id": "C2264953", "aliases": [], "types": ["T044"], "canonical_name": "PEP-dependent phosphotransferase enzyme II"}
{"concept_id": "C2264954", "aliases": [], "types": ["T044"], "canonical_name": "phosphoenolpyruvate-sugar phosphotransferase enzyme II"}
{"concept_id": "C2264958", "aliases": [], "types": ["T044"], "canonical_name": "protein, specific or class, gene bglC"}
{"concept_id": "C2264964", "aliases": [], "types": ["T044"], "canonical_name": "ribonucleic acid formation factor, gene glC"}
{"concept_id": "C2264965", "aliases": [], "types": ["T044"], "canonical_name": "sucrose phosphotransferase system II"}
{"concept_id": "C2264982", "aliases": ["CheB methylesterase activity"], "types": ["T044"], "canonical_name": "methylesterase CheB activity"}
{"concept_id": "C2264983", "aliases": [], "types": ["T044"], "canonical_name": "chemotaxis-specific methylesterase activity"}
{"concept_id": "C2264984", "aliases": [], "types": ["T044"], "canonical_name": "methyl-accepting chemotaxis protein methyl-esterase activity"}
{"concept_id": "C2264997", "aliases": [], "types": ["T045"], "canonical_name": "ErmC 23S rRNA methyltransferase"}
{"concept_id": "C2264998", "aliases": [], "types": ["T045"], "canonical_name": "gene ksgA methyltransferase"}
{"concept_id": "C2265032", "aliases": [], "types": ["T044"], "canonical_name": "D-alanine carboxypeptidase"}
{"concept_id": "C2265036", "aliases": ["DD-carboxypeptidase"], "types": ["T044"], "canonical_name": "DD-carboxypeptidase"}
{"concept_id": "C2265062", "aliases": [], "types": ["T044"], "canonical_name": "EcoRI methylase"}
{"concept_id": "C2265063", "aliases": ["modification methylase activity"], "types": ["T044"], "canonical_name": "modification methylase activity"}
{"concept_id": "C2265065", "aliases": ["restriction-modification system activity"], "types": ["T045"], "canonical_name": "restriction-modification system activity"}
{"concept_id": "C2265070", "aliases": [], "types": ["T044"], "canonical_name": "deoxyribonucleic acid modification methylase activity"}
{"concept_id": "C2265072", "aliases": [], "types": ["T044"], "canonical_name": "Type II DNA methylase"}
{"concept_id": "C2265089", "aliases": ["AAD (3'')"], "types": ["T044"], "canonical_name": "aminoglycoside 3''-adenylyltransferase activity", "definition": "Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H(+). [EC:2.7.7.47, RHEA:20245]"}
{"concept_id": "C2265099", "aliases": [], "types": ["T044"], "canonical_name": "disaccharide glucosyltransferase activity"}
{"concept_id": "C2265111", "aliases": [], "types": ["T045"], "canonical_name": "ribothymidyl synthase activity"}
{"concept_id": "C2265117", "aliases": [], "types": ["T045"], "canonical_name": "phosphate-dependent exonuclease activity"}
{"concept_id": "C2265146", "aliases": [], "types": ["T044"], "canonical_name": "lipid-A 4'-kinase activity"}
{"concept_id": "C2265171", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine recombinase"}
{"concept_id": "C2265176", "aliases": [], "types": ["T044"], "canonical_name": "isoprenoid alcohol kinase (phosphorylating)"}
{"concept_id": "C2265177", "aliases": ["isoprenoid alcohol kinase activity"], "types": ["T044"], "canonical_name": "isoprenoid-alcohol kinase activity"}
{"concept_id": "C2265179", "aliases": [], "types": ["T044"], "canonical_name": "polyisoprenol kinase activity"}
{"concept_id": "C2265185", "aliases": [], "types": ["T044"], "canonical_name": "transaminase C activity"}
{"concept_id": "C2265200", "aliases": [], "types": ["T044"], "canonical_name": "G enzyme"}
{"concept_id": "C2265201", "aliases": [], "types": ["T044"], "canonical_name": "Zn(2+) G peptidase activity"}
{"concept_id": "C2265204", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine biosynthetic process, prephenate pathway"}
{"concept_id": "C2265205", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine biosynthetic process, shikimate pathway"}
{"concept_id": "C2265211", "aliases": [], "types": ["T043"], "canonical_name": "chitin- and beta-glucan-containing cell wall biogenesis"}
{"concept_id": "C2265212", "aliases": [], "types": ["T026"], "canonical_name": "beta-glucan-containing cell wall"}
{"concept_id": "C2265213", "aliases": [], "types": ["T026"], "canonical_name": "chitin- and beta-glucan-containing cell wall"}
{"concept_id": "C2265214", "aliases": [], "types": ["T026"], "canonical_name": "chitin-containing cell wall"}
{"concept_id": "C2265215", "aliases": ["aminodeoxychorismate synthase complex location", "ADC synthase complex", "ADC synthase complex location"], "types": ["T026"], "canonical_name": "aminodeoxychorismate synthase complex", "definition": "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity. [PMID:2251281, PMID:7592344]"}
{"concept_id": "C2265216", "aliases": ["4-amino-4-deoxychorismate synthase complex location"], "types": ["T026"], "canonical_name": "4-amino-4-deoxychorismate synthase complex"}
{"concept_id": "C2265221", "aliases": ["ATP-dependent four-way junction DNA helicase activity", "ATP-dependent four-way junction helicase activity"], "types": ["T045"], "canonical_name": "four-way junction helicase activity", "definition": "Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis. [GOC:al, PMID:22723423, PMID:9442895]"}
{"concept_id": "C2265222", "aliases": [], "types": ["T045"], "canonical_name": "rRNA m5C967 methyltransferase activity"}
{"concept_id": "C2265232", "aliases": [], "types": ["T026"], "canonical_name": "flagellar basal body, distal rod, P ring"}
{"concept_id": "C2265233", "aliases": ["plastoquinol:oxidized-plastocyanin oxidoreductase activity", "plastoquinol/plastocyanin oxidoreductase activity", "plastoquinol-plastocyanin reductase activity"], "types": ["T044"], "canonical_name": "plastoquinol--plastocyanin reductase activity", "definition": "Catalysis of the reaction: 2 H(+)[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H(+)[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane. [RHEA:22148]"}
{"concept_id": "C2265243", "aliases": ["regulation of glutamine family amino acid metabolism"], "types": ["T044"], "canonical_name": "regulation of glutamine family amino acid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. [GOC:go_curators]"}
{"concept_id": "C2265244", "aliases": ["regulation of arginine metabolism"], "types": ["T044"], "canonical_name": "regulation of arginine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [GOC:go_curators]"}
{"concept_id": "C2265245", "aliases": ["IP6 binding", "InsP6 binding"], "types": ["T044"], "canonical_name": "inositol hexakisphosphate binding", "definition": "Binding to inositol hexakisphosphate. [GOC:go_curators]"}
{"concept_id": "C2265246", "aliases": ["inositol 1,4,5,6-tetrakisphosphate 3-kinase activity", "1D-myo-inositol-tetrakisphosphate 3-kinase activity", "inositol tetrakisphosphate 3-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. [GOC:elh]", "canonical_name": "IpmK"}
{"concept_id": "C2265247", "aliases": [], "types": ["T044"], "canonical_name": "EC:2.7.1.151"}
{"concept_id": "C2265250", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,3,4,5,6-pentakisphosphate kinase activity", "definition": "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. [GOC:elh, PMID:11311242]"}
{"concept_id": "C2265251", "aliases": [], "types": ["T044"], "canonical_name": "inositol heptakisphosphate kinase activity", "definition": "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown. [GOC:elh, PMID:16429326]"}
{"concept_id": "C2265252", "aliases": [], "types": ["T044"], "canonical_name": "inositol hexakisphosphate 4-kinase activity", "definition": "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate. [GOC:elh, PMID:16429326]"}
{"concept_id": "C2265253", "aliases": [], "types": ["T044"], "canonical_name": "inositol hexakisphosphate 6-kinase activity", "definition": "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate. [GOC:elh, PMID:16429326]"}
{"concept_id": "C2265254", "aliases": ["ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. [MetaCyc:2.7.1.152-RXN, RHEA:12793]", "canonical_name": "inositol hexakisphosphate 5-kinase activity"}
{"concept_id": "C2265255", "aliases": ["diphosphoinositol-pentakisphosphate 4-kinase activity", "IP7 4-kinase activity"], "types": ["T044"], "canonical_name": "inositol heptakisphosphate 4-kinase activity", "definition": "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate. [GOC:elh, PMID:16429326]"}
{"concept_id": "C2265256", "aliases": [], "types": ["T044"], "canonical_name": "inositol heptakisphosphate 6-kinase activity", "definition": "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate. [GOC:elh, PMID:16429326]"}
{"concept_id": "C2265257", "aliases": ["ER ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "ER ubiquitin ligase complex", "definition": "A ubiquitin ligase complex found in the ER. [GOC:elh]"}
{"concept_id": "C2265258", "aliases": ["Hrd1p ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "Hrd1p ubiquitin ligase complex", "definition": "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78). [GOC:bf, GOC:elh, PMID:16619026, PMID:16873066, PMID:21454652]"}
{"concept_id": "C2265259", "aliases": ["Doa10p ubiquitin ligase complex location", "Ssm4p ubiquitin ligase complex location", "Ssm4p ubiquitin ligase complex"], "types": ["T026"], "canonical_name": "Doa10p ubiquitin ligase complex", "definition": "A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p. [GOC:elh, PMID:16873066]"}
{"concept_id": "C2265260", "aliases": ["Hrd1p ubiquitin ligase ERAD-M complex location"], "types": ["T026"], "canonical_name": "Hrd1p ubiquitin ligase ERAD-M complex", "definition": "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. [GOC:elh, PMID:16873066]"}
{"concept_id": "C2265261", "aliases": ["Hrd1p ubiquitin ligase ERAD-L complex location"], "types": ["T026"], "canonical_name": "Hrd1p ubiquitin ligase ERAD-L complex", "definition": "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. [GOC:elh, PMID:16873065, PMID:16873066]"}
{"concept_id": "C2265262", "aliases": ["conidium development"], "types": ["T040"], "canonical_name": "conidium development", "definition": "The process whose specific outcome is the progression of conidium over time, from its formation to the mature structure. Conidia are non-motile spores produced via mitotic asexual reproduction in higher fungi; they are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. [GOC:di, GOC:dph]"}
{"concept_id": "C2265268", "aliases": ["ascus development"], "types": ["T040"], "canonical_name": "ascus development", "definition": "The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed. [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators]"}
{"concept_id": "C2265269", "aliases": [], "types": ["T040"], "canonical_name": "perfect stage fruiting body development"}
{"concept_id": "C2265274", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic foci"}
{"concept_id": "C2265275", "aliases": [], "types": ["T045"], "canonical_name": "base pairing with rRNA"}
{"concept_id": "C2265276", "aliases": [], "types": ["T045"], "canonical_name": "base pairing with snRNA"}
{"concept_id": "C2265277", "aliases": [], "types": ["T045"], "canonical_name": "base pairing with tRNA"}
{"concept_id": "C2265278", "aliases": [], "types": ["T044"], "canonical_name": "amino acid catabolic process to alcohol via Ehrlich pathway", "definition": "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. [GOC:krc, PMID:18281432]"}
{"concept_id": "C2265279", "aliases": [], "types": ["T044"], "canonical_name": "amino acid catabolic process to carboxylic acid via Ehrlich pathway", "definition": "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. [GOC:krc, PMID:18281432]"}
{"concept_id": "C2265280", "aliases": [], "types": ["T044"], "canonical_name": "aromatic amino acid family catabolic process to alcohol via Ehrlich pathway", "definition": "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. [GOC:krc, PMID:18281432]"}
{"concept_id": "C2265281", "aliases": ["branched chain family amino acid catabolic process to alcohol via Ehrlich pathway"], "types": ["T044"], "canonical_name": "branched-chain amino acid catabolic process to alcohol via Ehrlich pathway", "definition": "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. [GOC:krc, PMID:18281432]"}
{"concept_id": "C2265282", "aliases": [], "types": ["T044"], "canonical_name": "methionine catabolic process to 3-methylthiopropanol", "definition": "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. [GOC:krc, PMID:18281432]"}
{"concept_id": "C2265283", "aliases": [], "types": ["T044"], "canonical_name": "aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway", "definition": "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. [GOC:krc, PMID:18281432]"}
{"concept_id": "C2265284", "aliases": ["branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway"], "types": ["T044"], "canonical_name": "branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway", "definition": "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. [GOC:krc, PMID:18281432]"}
{"concept_id": "C2265285", "aliases": [], "types": ["T044"], "canonical_name": "methionine catabolic process to 3-methylthiopropanoate", "definition": "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. [GOC:krc, PMID:18281432]"}
{"concept_id": "C2265286", "aliases": [], "types": ["T044"], "canonical_name": "amino acid catabolic process via Ehrlich pathway", "definition": "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols. [GOC:krc, PMID:18281432]"}
{"concept_id": "C2265288", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of exit from mitosis"}
{"concept_id": "C2265289", "aliases": ["chlamydospore development"], "types": ["T043"], "canonical_name": "chlamydospore formation", "definition": "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans. [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094]"}
{"concept_id": "C2265291", "aliases": ["plant-type hypersensitive response", "HR-PCD", "plant hypersensitive response"], "types": ["T038"], "definition": "The rapid, localized death of plant cells in response to invasion by a pathogen. [ISBN:0582227089]", "canonical_name": "HR"}
{"concept_id": "C2265293", "aliases": ["sucrose:monovalent cation symporter activity"], "types": ["T044"], "canonical_name": "sucrose:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in). [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1]"}
{"concept_id": "C2265294", "aliases": ["low affinity phosphate transmembrane transporter activity"], "types": ["T044"], "canonical_name": "low-affinity phosphate transmembrane transporter activity", "definition": "Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [TC:2.A.20.-.-]"}
{"concept_id": "C2265307", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of abscisic acid mediated signaling"}
{"concept_id": "C2265308", "aliases": [], "types": ["T044"], "canonical_name": "activation of abscisic acid mediated signaling"}
{"concept_id": "C2265309", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of abscisic acid mediated signaling"}
{"concept_id": "C2265311", "aliases": [], "types": ["T042"], "canonical_name": "embryo development ending in birth or egg hatching", "definition": "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]"}
{"concept_id": "C2265320", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of biosynthetic process"}
{"concept_id": "C2265321", "aliases": [], "types": ["T044"], "canonical_name": "activation of biosynthetic process"}
{"concept_id": "C2265322", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of biosynthetic process"}
{"concept_id": "C2265325", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metabolic process"}
{"concept_id": "C2265326", "aliases": [], "types": ["T040"], "canonical_name": "activation of metabolic process"}
{"concept_id": "C2265327", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of metabolic process"}
{"concept_id": "C2265330", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of catabolic process"}
{"concept_id": "C2265331", "aliases": [], "types": ["T040"], "canonical_name": "activation of catabolic process"}
{"concept_id": "C2265332", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of catabolic process"}
{"concept_id": "C2265336", "aliases": [], "types": ["T044"], "canonical_name": "ent-kaurene synthase B activity"}
{"concept_id": "C2265337", "aliases": [], "types": ["T044"], "canonical_name": "ent-kaurene synthetase B activity"}
{"concept_id": "C2265339", "aliases": [], "types": ["T044"], "canonical_name": "ent-kaurene synthase A activity"}
{"concept_id": "C2265340", "aliases": [], "types": ["T044"], "canonical_name": "ent-kaurene synthetase A activity"}
{"concept_id": "C2265342", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of flower development"}
{"concept_id": "C2265343", "aliases": [], "types": ["T042"], "canonical_name": "activation of flower development"}
{"concept_id": "C2265344", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of flower development"}
{"concept_id": "C2265346", "aliases": ["cell plate formation involved in cellulose and pectin-containing cell wall biogenesis"], "types": ["T043"], "canonical_name": "cell plate formation involved in plant-type cell wall biogenesis", "definition": "The cell cycle process in which the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana. [GOC:mtg_sensu, GOC:tb, ISBN:0879015322]"}
{"concept_id": "C2265348", "aliases": [], "types": ["T026"], "canonical_name": "longitudinal side of cell surface", "definition": "The side of the cell parallel to the zygotic axis. [GOC:mtg_sensu, GOC:sm]"}
{"concept_id": "C2265350", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of gibberellic acid mediated signaling"}
{"concept_id": "C2265351", "aliases": [], "types": ["T044"], "canonical_name": "activation of gibberellic acid mediated signaling"}
{"concept_id": "C2265352", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of gibberellic acid mediated signaling"}
{"concept_id": "C2265354", "aliases": [], "types": ["T040"], "canonical_name": "activation of flavonoid biosynthetic process"}
{"concept_id": "C2265355", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of flavonoid biosynthetic process"}
{"concept_id": "C2265358", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of flavonoid biosynthetic process"}
{"concept_id": "C2265359", "aliases": [], "types": ["T040"], "canonical_name": "activation of signal transduction"}
{"concept_id": "C2265360", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of signal transduction"}
{"concept_id": "C2265364", "aliases": ["arginine targeting transmembrane transporter activity", "delta-pH-dependent protein transporter activity", "pH-dependent protein transporter activity", "twin-arginine targeting transmembrane transporter activity"], "types": ["T044"], "canonical_name": "proton motive force dependent protein transmembrane transporter activity", "definition": "Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane. [PMID:11526245, PMID:25494301]"}
{"concept_id": "C2265369", "aliases": [], "types": ["T043"], "canonical_name": "cellular water homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of water within a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265371", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell fate specification"}
{"concept_id": "C2265373", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardioblast cell fate specification"}
{"concept_id": "C2265375", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of retinal cone cell fate specification"}
{"concept_id": "C2265377", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of auditory receptor cell fate specification"}
{"concept_id": "C2265378", "aliases": [], "types": ["T040"], "canonical_name": "activation of seed germination"}
{"concept_id": "C2265379", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of seed germination"}
{"concept_id": "C2265381", "aliases": [], "types": ["T043"], "canonical_name": "stomatal cell differentiation"}
{"concept_id": "C2265382", "aliases": [], "types": ["T043"], "canonical_name": "regulation of atrichoblast fate specification", "definition": "Any process that modulates atrichoblast fate specification. [GOC:tb]"}
{"concept_id": "C2265383", "aliases": [], "types": ["T043"], "canonical_name": "activation of atrichoblast fate"}
{"concept_id": "C2265384", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of atrichoblast fate"}
{"concept_id": "C2265385", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of atrichoblast fate"}
{"concept_id": "C2265386", "aliases": [], "types": ["T043"], "canonical_name": "regulation of trichoblast fate specification", "definition": "Any process that modulates trichoblast fate specification. [GOC:tb]"}
{"concept_id": "C2265387", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of trichoblast fate"}
{"concept_id": "C2265388", "aliases": [], "types": ["T043"], "canonical_name": "activation of trichoblast fate"}
{"concept_id": "C2265389", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of trichoblast fate"}
{"concept_id": "C2265391", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of photomorphogenesis"}
{"concept_id": "C2265393", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ethylene mediated signaling pathway"}
{"concept_id": "C2265396", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of systemic acquired resistance"}
{"concept_id": "C2265397", "aliases": [], "types": ["T044"], "canonical_name": "activation of abscisic acid biosynthetic process"}
{"concept_id": "C2265398", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of abscisic acid biosynthetic process"}
{"concept_id": "C2265406", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular defense response"}
{"concept_id": "C2265407", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cellular defense response"}
{"concept_id": "C2265410", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of seed germination"}
{"concept_id": "C2265411", "aliases": ["cellular aluminium ion homeostasis"], "types": ["T043"], "canonical_name": "cellular aluminum ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of aluminum ions at the level of a cell. [GOC:lr, GOC:mah]"}
{"concept_id": "C2265412", "aliases": [], "types": ["T040"], "canonical_name": "activation of vernalization response"}
{"concept_id": "C2265413", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of vernalization response"}
{"concept_id": "C2265416", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of vernalization response"}
{"concept_id": "C2265417", "aliases": [], "types": ["T040"], "canonical_name": "auxiliary shoot formation"}
{"concept_id": "C2265418", "aliases": [], "types": ["T040"], "canonical_name": "axillary shoot formation"}
{"concept_id": "C2265420", "aliases": ["plastid pyruvate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "plastid pyruvate dehydrogenase complex", "definition": "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria. [GOC:mtg_sensu, PMID:9393637]"}
{"concept_id": "C2265422", "aliases": ["7-hydroxychlorophyllide-a oxygenase activity", "chlorophyll b synthetase activity", "chlorophyll-b synthase activity", "7-hydroxychlorophyllide a:oxygen 7-oxidoreductase activity"], "types": ["T044"], "canonical_name": "7-hydroxy-chlorophyllide a oxygenase activity", "definition": "Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O. [EC:1.13.12.14, MetaCyc:RXN-7677]"}
{"concept_id": "C2265429", "aliases": [], "types": ["T044"], "canonical_name": "AOdelta"}
{"concept_id": "C2265436", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity"}
{"concept_id": "C2265437", "aliases": ["ARD activity", "acireductone dioxygenase activity"], "types": ["T044"], "canonical_name": "acireductone dioxygenase activity"}
{"concept_id": "C2265440", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase"}
{"concept_id": "C2265441", "aliases": [], "types": ["T044"], "canonical_name": "aci-reductone dioxygenase"}
{"concept_id": "C2265444", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway"}
{"concept_id": "C2265445", "aliases": [], "types": ["T044"], "canonical_name": "auxin influx transmembrane transporter activity", "definition": "Enables the transfer of auxin, from one side of a membrane to the other, into a cell. [PMID:16839804]"}
{"concept_id": "C2265446", "aliases": [], "types": ["T044"], "canonical_name": "auxin efflux transmembrane transporter activity", "definition": "Enables the transfer of auxin, from one side of a membrane to the other, out of a cell. [PMID:16839804]"}
{"concept_id": "C2265447", "aliases": ["response to gamma ray"], "types": ["T040"], "canonical_name": "response to gamma radiation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. [GOC:tair_curators]"}
{"concept_id": "C2265449", "aliases": [], "types": ["T040"], "canonical_name": "response to gamma-ray photon"}
{"concept_id": "C2265450", "aliases": [], "types": ["T043"], "canonical_name": "response to non-ionic osmotic stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment. [GOC:tair_curators]"}
{"concept_id": "C2265451", "aliases": ["gibberellin homeostasis"], "types": ["T039"], "canonical_name": "gibberellic acid homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation. [PMID:17194763]"}
{"concept_id": "C2265453", "aliases": [], "types": ["T040"], "canonical_name": "regulation of salicylic acid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid. [PMID:14765119]"}
{"concept_id": "C2265454", "aliases": [], "types": ["T040"], "canonical_name": "regulation of salicylic acid metabolism"}
{"concept_id": "C2265455", "aliases": [], "types": ["T042"], "canonical_name": "leaf formation", "definition": "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts. [GOC:tair_curators]"}
{"concept_id": "C2265456", "aliases": [], "types": ["T026"], "canonical_name": "external side of cell wall", "definition": "The side of the cell wall that is opposite to the side that faces the cell and its contents. [GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C2265457", "aliases": [], "types": ["T044"], "canonical_name": "carboxyl-O-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. [PMID:17220201]"}
{"concept_id": "C2265458", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin carboxyl-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester. [PMID:17220201]"}
{"concept_id": "C2265459", "aliases": ["cellularization of endosperm"], "types": ["T043"], "canonical_name": "endosperm cellularization", "definition": "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization. [PMID:12421698]"}
{"concept_id": "C2265460", "aliases": ["programmed cell death in response to singlet oxygen"], "types": ["T043"], "canonical_name": "singlet oxygen-mediated programmed cell death", "definition": "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes. [GOC:mtg_apoptosis, PMID:17075038]"}
{"concept_id": "C2265461", "aliases": [], "types": ["T043"], "canonical_name": "light-dependent programmed cell death"}
{"concept_id": "C2265462", "aliases": ["seed oil body organization"], "types": ["T043"], "canonical_name": "seed oilbody biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination. [GOC:jl, PMID:16877495]"}
{"concept_id": "C2265463", "aliases": [], "types": ["T043"], "canonical_name": "oleosome biogenesis"}
{"concept_id": "C2265464", "aliases": [], "types": ["T043"], "canonical_name": "spherosome biogenesis"}
{"concept_id": "C2265465", "aliases": [], "types": ["T040"], "canonical_name": "suberin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols. [PMID:17259262]"}
{"concept_id": "C2265466", "aliases": [], "types": ["T040"], "canonical_name": "shoot formation"}
{"concept_id": "C2265467", "aliases": [], "types": ["T044"], "canonical_name": "L-galactose-1-phosphate phosphatase activity", "definition": "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate. [PMID:15550539, PMID:16595667]"}
{"concept_id": "C2265468", "aliases": ["lithium:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "lithium:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in). [PMID:17270011]"}
{"concept_id": "C2265469", "aliases": [], "types": ["T044"], "canonical_name": "L-galactose dehydrogenase activity", "definition": "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+. [PMID:12047629, RHEA:31559]"}
{"concept_id": "C2265470", "aliases": [], "types": ["T044"], "canonical_name": "L-galactose 1-dehydrogenase activity"}
{"concept_id": "C2265471", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to magnesium starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium. [PMID:17270009]"}
{"concept_id": "C2265472", "aliases": ["lithium ion transport"], "types": ["T043"], "definition": "The directed movement of lithium ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [PMID:17270011]", "canonical_name": "lithium transport"}
{"concept_id": "C2265473", "aliases": ["lithium ion export", "lithium export"], "types": ["T043"], "canonical_name": "lithium ion export across the plasma membrane", "definition": "The directed movement of lithium ion out of a cell or organelle. [PMID:17270011]"}
{"concept_id": "C2265474", "aliases": [], "types": ["T043"], "canonical_name": "lithium ion efflux"}
{"concept_id": "C2265475", "aliases": ["response to trehalose stimulus"], "types": ["T043"], "canonical_name": "response to trehalose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus. [PMID:17031512]"}
{"concept_id": "C2265476", "aliases": [], "types": ["T044"], "canonical_name": "homogentisate prenyltransferase activity", "definition": "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid. [PMID:16989822]"}
{"concept_id": "C2265477", "aliases": [], "types": ["T044"], "canonical_name": "homogentisate farnesyltransferase activity", "definition": "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol. [PMID:16989822]"}
{"concept_id": "C2265478", "aliases": [], "types": ["T044"], "canonical_name": "homogentisate geranylgeranyltransferase activity", "definition": "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol. [PMID:16989822]"}
{"concept_id": "C2265479", "aliases": [], "types": ["T044"], "canonical_name": "homogentisate solanesyltransferase activity", "definition": "Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate. [PMID:16989822]"}
{"concept_id": "C2265480", "aliases": [], "types": ["T040"], "canonical_name": "leaf shaping", "definition": "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed. [GOC:tb, PMID:16971475]"}
{"concept_id": "C2265481", "aliases": [], "types": ["T040"], "canonical_name": "leaf structural organization"}
{"concept_id": "C2265482", "aliases": [], "types": ["T039"], "canonical_name": "regulation of anion channel activity", "definition": "Any process that modulates the frequency, rate or extent of anion channel activity. [PMID:17319842]"}
{"concept_id": "C2265483", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of anion channel activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity. [PMID:17319842]"}
{"concept_id": "C2265484", "aliases": ["regulation by blue light of anion channel activity"], "types": ["T039"], "canonical_name": "regulation of anion channel activity by blue light", "definition": "Any process in which blue light modulates the frequency, rate or extent of anion channel activity. [GOC:dph, GOC:tb, PMID:17319842]"}
{"concept_id": "C2265485", "aliases": ["negative regulation by blue light of anion channel activity"], "types": ["T039"], "canonical_name": "negative regulation of anion channel activity by blue light", "definition": "Any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity. [PMID:17319842]"}
{"concept_id": "C2265486", "aliases": [], "types": ["T039"], "canonical_name": "inhibition by blue light of anion channel activity"}
{"concept_id": "C2265487", "aliases": ["regulation of HR", "regulation of plant hypersensitive response", "regulation of HR-PCD"], "types": ["T043"], "canonical_name": "regulation of plant-type hypersensitive response", "definition": "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response. [PMID:16255244]"}
{"concept_id": "C2265488", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ethylene biosynthetic process", "definition": "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process. [GOC:tair_curators]"}
{"concept_id": "C2265489", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ethylene biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process. [GOC:tair_curators]"}
{"concept_id": "C2265490", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ethylene biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process. [GOC:tair_curators]"}
{"concept_id": "C2265491", "aliases": ["extracellular isoamylase complex location"], "types": ["T026"], "canonical_name": "extracellular isoamylase complex", "definition": "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space. [GOC:tair_curators]"}
{"concept_id": "C2265492", "aliases": ["chloroplast isoamylase complex location"], "types": ["T026"], "canonical_name": "chloroplast isoamylase complex", "definition": "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized. [GOC:tair_curators]"}
{"concept_id": "C2265493", "aliases": [], "types": ["T026"], "canonical_name": "chromocenter", "definition": "A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure. [PMID:12384572, PMID:15053486, PMID:16831888]"}
{"concept_id": "C2265494", "aliases": [], "types": ["T026"], "canonical_name": "perinucleolar chromocenter", "definition": "A chromocenter adjacent to the nucleolus. [PMID:15805479]"}
{"concept_id": "C2265495", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gibberellin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins. [GOC:tair_curators]"}
{"concept_id": "C2265496", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gibberellic acid biosynthetic process"}
{"concept_id": "C2265497", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of gibberellin biosynthetic process", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins. [GOC:tair_curators]"}
{"concept_id": "C2265498", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of gibberellic acid biosynthetic process"}
{"concept_id": "C2265499", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of gibberellin biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins. [GOC:tair_curators]"}
{"concept_id": "C2265500", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of gibberellic acid biosynthetic process"}
{"concept_id": "C2265501", "aliases": [], "types": ["T040"], "canonical_name": "stomatal complex development", "definition": "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells. [PMID:17259259]"}
{"concept_id": "C2265502", "aliases": [], "types": ["T042"], "canonical_name": "stomatal complex patterning", "definition": "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells. [PMID:17259259]"}
{"concept_id": "C2265503", "aliases": [], "types": ["T040"], "canonical_name": "stomatal complex formation", "definition": "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells. [PMID:17259259]"}
{"concept_id": "C2265504", "aliases": [], "types": ["T043"], "canonical_name": "guard cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere. [PMID:17259259]"}
{"concept_id": "C2265505", "aliases": [], "types": ["T043"], "canonical_name": "stomatal cell fate commitment"}
{"concept_id": "C2265506", "aliases": [], "types": ["T039"], "canonical_name": "temperature compensation of the circadian clock", "definition": "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms. [PMID:16617099]"}
{"concept_id": "C2265507", "aliases": [], "types": ["T043"], "canonical_name": "phaseic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA). [BioCyc:PWY-5271]"}
{"concept_id": "C2265508", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chlorophyll biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. [PMID:17291312]"}
{"concept_id": "C2265509", "aliases": ["attachment of peroxisome to chloroplast"], "types": ["T039"], "canonical_name": "peroxisome-chloroplast membrane tethering", "definition": "The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. [PMID:17215364]"}
{"concept_id": "C2265511", "aliases": [], "types": ["T043"], "canonical_name": "cell wall polysaccharide metabolic process", "definition": "The chemical reactions and pathways involving cell wall polysaccharides. [GOC:tair_curators]"}
{"concept_id": "C2265512", "aliases": ["cell wall proteoglycan metabolism"], "types": ["T044"], "canonical_name": "cell wall proteoglycan metabolic process", "definition": "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates. [GOC:tair_curators]"}
{"concept_id": "C2265513", "aliases": [], "types": ["T045"], "canonical_name": "double-stranded methylated DNA binding", "definition": "Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. [GOC:imk, PMID:17242155]"}
{"concept_id": "C2265515", "aliases": ["signalosome assembly"], "types": ["T044"], "canonical_name": "COP9 signalosome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome. [PMID:17307927]"}
{"concept_id": "C2265516", "aliases": [], "types": ["T044"], "canonical_name": "cullin deneddylation"}
{"concept_id": "C2265517", "aliases": ["regulation of mitotic entry"], "types": ["T043"], "canonical_name": "regulation of G2/M transition of mitotic cell cycle", "definition": "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. [GOC:mtg_cell_cycle, PMID:17329565]"}
{"concept_id": "C2265518", "aliases": [], "types": ["T044"], "canonical_name": "histone monoubiquitination", "definition": "The modification of histones by addition of a single ubiquitin group. [PMID:17329563]"}
{"concept_id": "C2265519", "aliases": ["glucomannan metabolism"], "types": ["T043"], "canonical_name": "glucomannan metabolic process", "definition": "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units. [GOC:tair_curators]"}
{"concept_id": "C2265520", "aliases": [], "types": ["T043"], "canonical_name": "galactoglucomannan metabolic process", "definition": "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units. [GOC:tair_curators]"}
{"concept_id": "C2265521", "aliases": [], "types": ["T043"], "canonical_name": "galactoglucomannan metabolism"}
{"concept_id": "C2265522", "aliases": ["galacturonan metabolism"], "types": ["T044"], "canonical_name": "galacturonan metabolic process", "definition": "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues. [GOC:tair_curators]"}
{"concept_id": "C2265523", "aliases": ["homogalacturonan metabolism"], "types": ["T044"], "canonical_name": "homogalacturonan metabolic process", "definition": "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. [GOC:tair_curators]"}
{"concept_id": "C2265524", "aliases": ["rhamnogalacturonan I metabolism"], "types": ["T044"], "canonical_name": "rhamnogalacturonan I metabolic process", "definition": "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone. [GOC:tair_curators]"}
{"concept_id": "C2265525", "aliases": [], "types": ["T044"], "canonical_name": "RGI metabolism"}
{"concept_id": "C2265526", "aliases": ["rhamnogalacturonan II metabolism"], "types": ["T044"], "canonical_name": "rhamnogalacturonan II metabolic process", "definition": "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues. [GOC:tair_curators]"}
{"concept_id": "C2265527", "aliases": ["apiogalacturonan metabolism"], "types": ["T044"], "canonical_name": "apiogalacturonan metabolic process", "definition": "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(1->3)-D-apiose) side chains via O-2 or O-3 links. [GOC:tair_curators]"}
{"concept_id": "C2265528", "aliases": ["xylogalacturonan metabolism"], "types": ["T044"], "canonical_name": "xylogalacturonan metabolic process", "definition": "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues. [GOC:tair_curators]"}
{"concept_id": "C2265529", "aliases": ["rhamnogalacturonan I backbone metabolism"], "types": ["T044"], "canonical_name": "rhamnogalacturonan I backbone metabolic process", "definition": "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone. [GOC:tair_curators]"}
{"concept_id": "C2265530", "aliases": ["rhamnogalacturonan I side chain metabolism"], "types": ["T044"], "canonical_name": "rhamnogalacturonan I side chain metabolic process", "definition": "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I. [GOC:tair_curators]"}
{"concept_id": "C2265531", "aliases": ["pectic galactan metabolism"], "types": ["T044"], "canonical_name": "pectic galactan metabolic process", "definition": "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I. [GOC:tair_curators]"}
{"concept_id": "C2265532", "aliases": ["pectic arabinan metabolism"], "types": ["T044"], "canonical_name": "pectic arabinan metabolic process", "definition": "The chemical reactions and pathways involving pectic arabinan, a polymer with an alpha-(1->5)-linked L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I. [GOC:tair_curators]"}
{"concept_id": "C2265533", "aliases": ["pectic arabinogalactan I metabolism"], "types": ["T044"], "canonical_name": "pectic arabinogalactan I metabolic process", "definition": "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1,4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I. [GOC:tair_curators]"}
{"concept_id": "C2265534", "aliases": ["cell wall hydroxyproline-rich glycoprotein metabolism"], "types": ["T044"], "canonical_name": "cell wall hydroxyproline-rich glycoprotein metabolic process", "definition": "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates. [GOC:tair_curators]"}
{"concept_id": "C2265535", "aliases": ["arabinogalactan protein metabolism"], "types": ["T044"], "canonical_name": "arabinogalactan protein metabolic process", "definition": "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures. [GOC:tair_curators]"}
{"concept_id": "C2265536", "aliases": ["classical-arabinogalactan protein metabolism"], "types": ["T044"], "canonical_name": "classical arabinogalactan protein metabolic process", "definition": "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored. [GOC:tair_curators]"}
{"concept_id": "C2265537", "aliases": ["non-classical arabinogalactan protein metabolism"], "types": ["T044"], "canonical_name": "non-classical arabinogalactan protein metabolic process", "definition": "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains. [GOC:tair_curators]"}
{"concept_id": "C2265538", "aliases": ["fasciclin-like arabinogalactan protein metabolism"], "types": ["T044"], "canonical_name": "fasciclin-like arabinogalactan protein metabolic process", "definition": "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain. [GOC:tair_curators]"}
{"concept_id": "C2265539", "aliases": ["extensin metabolism"], "types": ["T044"], "canonical_name": "extensin metabolic process", "definition": "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated. [GOC:tair_curators]"}
{"concept_id": "C2265540", "aliases": ["hemicellulose metabolism"], "types": ["T043"], "canonical_name": "hemicellulose metabolic process", "definition": "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present. [GOC:tair_curators]"}
{"concept_id": "C2265541", "aliases": ["xyloglucan metabolism"], "types": ["T043"], "canonical_name": "xyloglucan metabolic process", "definition": "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants. [GOC:tair_curators]"}
{"concept_id": "C2265542", "aliases": ["glucuronoxylan metabolism"], "types": ["T044"], "canonical_name": "glucuronoxylan metabolic process", "definition": "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units. [GOC:tair_curators]"}
{"concept_id": "C2265543", "aliases": ["glucuronoarabinoxylan metabolism"], "types": ["T044"], "canonical_name": "glucuronoarabinoxylan metabolic process", "definition": "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units. [GOC:tair_curators]"}
{"concept_id": "C2265544", "aliases": ["unsubstituted mannan metabolism"], "types": ["T043"], "canonical_name": "unsubstituted mannan metabolic process", "definition": "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units. [GOC:tair_curators]"}
{"concept_id": "C2265545", "aliases": ["arabinoxylan metabolism"], "types": ["T044"], "canonical_name": "arabinoxylan-containing compound metabolic process", "definition": "The chemical reactions and pathways involving an arabinoxylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units. [GOC:tair_curators]"}
{"concept_id": "C2265546", "aliases": ["glucuronoxylan formation", "glucuronoxylan synthesis", "glucuronoxylan biosynthesis", "glucuronoxylan anabolism"], "types": ["T044"], "canonical_name": "glucuronoxylan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues. [GOC:tair_curators]"}
{"concept_id": "C2265547", "aliases": ["rhamnogalacturonan II backbone metabolism"], "types": ["T044"], "canonical_name": "rhamnogalacturonan II backbone metabolic process", "definition": "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues. [GOC:tair_curators]"}
{"concept_id": "C2265548", "aliases": ["rhamnogalacturonan II side chain metabolism"], "types": ["T044"], "canonical_name": "rhamnogalacturonan II side chain metabolic process", "definition": "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively. [GOC:tair_curators]"}
{"concept_id": "C2265549", "aliases": [], "types": ["T044"], "canonical_name": "polyprenyldihydroxybenzoate methyltransferase activity"}
{"concept_id": "C2265550", "aliases": ["programmed cell death in response to hydrogen peroxide"], "types": ["T043"], "canonical_name": "hydrogen peroxide-mediated programmed cell death", "definition": "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes. [GOC:mtg_apoptosis, PMID:16036580]"}
{"concept_id": "C2265551", "aliases": [], "types": ["T040"], "canonical_name": "regulation of brassinosteroid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids. [PMID:16857903]"}
{"concept_id": "C2265552", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of brassinosteroid biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids. [PMID:16857903]"}
{"concept_id": "C2265553", "aliases": ["cytosine methylation within a CG sequence"], "types": ["T045"], "canonical_name": "DNA methylation on cytosine within a CG sequence", "definition": "The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule. [GOC:dph, GOC:tb, PMID:17239600]"}
{"concept_id": "C2265554", "aliases": ["cytosine methylation within a CNG sequence"], "types": ["T045"], "canonical_name": "DNA methylation on cytosine within a CNG sequence", "definition": "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide. [GOC:dph, GOC:tb, PMID:17239600]"}
{"concept_id": "C2265555", "aliases": ["cytosine methylation within a CHH sequence", "DNA methylation on cytosine within a CNN sequence", "cytosine methylation within a CNN sequence"], "types": ["T045"], "canonical_name": "DNA methylation on cytosine within a CHH sequence", "definition": "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide. [GOC:dph, GOC:mah, GOC:tb, PMID:15861207, PMID:17239600]"}
{"concept_id": "C2265559", "aliases": [], "types": ["T044"], "canonical_name": "methyl-CpNpG binding", "definition": "Binding to a methylated cytosine/unspecified/guanine trinucleotide. [PMID:17239600]"}
{"concept_id": "C2265560", "aliases": [], "types": ["T044"], "canonical_name": "methyl-CpNpN binding", "definition": "Binding to a methylated cytosine/unspecified/unspecified trinucleotide. [PMID:17239600]"}
{"concept_id": "C2265561", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid omega-oxidation", "definition": "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation. [MetaCyc:PWY-2724, PMID:16404574]"}
{"concept_id": "C2265562", "aliases": [], "types": ["T039"], "canonical_name": "seed maturation", "definition": "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination. [PMID:16096971]"}
{"concept_id": "C2265563", "aliases": [], "types": ["T042"], "canonical_name": "bract development", "definition": "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. [GOC:tb, PMID:16554366, PO:0009055]"}
{"concept_id": "C2265564", "aliases": [], "types": ["T042"], "canonical_name": "bract morphogenesis", "definition": "The process in which the anatomical structure of a bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. [GOC:tb, PMID:16554366, PO:0009055]"}
{"concept_id": "C2265565", "aliases": [], "types": ["T040"], "canonical_name": "bract formation", "definition": "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. [GOC:tb, PMID:16554366, PO:0009055]"}
{"concept_id": "C2265566", "aliases": ["OPC-8:0 CoA ligase activity", "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity", "3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity"], "types": ["T044"], "canonical_name": "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity", "definition": "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0. [PMID:16963437]"}
{"concept_id": "C2265568", "aliases": [], "types": ["T044"], "canonical_name": "carotenoid dioxygenase activity", "definition": "Catalysis of the oxidative cleavage of carotenoids. [PMID:16459333]"}
{"concept_id": "C2265569", "aliases": [], "types": ["T044"], "canonical_name": "carotenoid-cleaving dioxygenase"}
{"concept_id": "C2265570", "aliases": [], "types": ["T044"], "canonical_name": "9,10 (9', 10')-carotenoid-cleaving dioxygenase activity", "definition": "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond. [PMID:16459333]"}
{"concept_id": "C2265571", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to sulfur starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur. [PMID:17420480]"}
{"concept_id": "C2265572", "aliases": [], "types": ["T040"], "canonical_name": "regulation of glucosinolate biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. [PMID:17420480]"}
{"concept_id": "C2265573", "aliases": [], "types": ["T043"], "canonical_name": "stomatal lineage progression", "definition": "The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex. [GOC:expert_db, GOC:tb]"}
{"concept_id": "C2265574", "aliases": [], "types": ["T043"], "canonical_name": "guard cell development", "definition": "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure. [GOC:tb]"}
{"concept_id": "C2265575", "aliases": ["guard cell morphogenesis during differentiation"], "types": ["T043"], "canonical_name": "guard cell morphogenesis", "definition": "Generation and organization of the polarized cell that is capable of turgor driven movement. [GOC:expert_db, GOC:tb]"}
{"concept_id": "C2265576", "aliases": [], "types": ["T043"], "canonical_name": "meristemoid mother cell division", "definition": "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC. [GOC:expert_db, GOC:tb]"}
{"concept_id": "C2265577", "aliases": [], "types": ["T043"], "canonical_name": "meristemoid division"}
{"concept_id": "C2265578", "aliases": [], "types": ["T043"], "canonical_name": "guard mother cell differentiation", "definition": "The process in which a meristemoid acquires the specialized features of a guard mother cell. [GOC:expert_db, GOC:tb]"}
{"concept_id": "C2265579", "aliases": ["D body"], "types": ["T026"], "definition": "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes. [PMID:17442570]", "canonical_name": "nuclear dicing body"}
{"concept_id": "C2265580", "aliases": ["response to alkalinity", "response to basic pH"], "types": ["T040"], "canonical_name": "response to alkaline pH", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:go_curators, GOC:tb, Wikipedia:PH]"}
{"concept_id": "C2265581", "aliases": ["response to acidity"], "types": ["T040"], "canonical_name": "response to acidic pH", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:go_curators, GOC:tb, Wikipedia:PH]"}
{"concept_id": "C2265582", "aliases": [], "types": ["T040"], "canonical_name": "vegetative meristem growth", "definition": "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia. [GOC:tb, ISBN:0849397928]"}
{"concept_id": "C2265583", "aliases": [], "types": ["T040"], "canonical_name": "root meristem growth", "definition": "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root. [GOC:tb]"}
{"concept_id": "C2265584", "aliases": [], "types": ["T040"], "canonical_name": "inflorescence meristem growth", "definition": "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers. [GOC:tb]"}
{"concept_id": "C2265585", "aliases": [], "types": ["T040"], "canonical_name": "floral meristem growth", "definition": "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower. [GOC:tb]"}
{"concept_id": "C2265586", "aliases": ["histone H3 K36 methylation", "histone lysine H3 K36 methylation", "histone H3K36me"], "types": ["T044"], "canonical_name": "histone H3-K36 methylation", "definition": "The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone. [GOC:pr, GOC:tb]"}
{"concept_id": "C2265587", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell fate commitment", "definition": "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265588", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell fate commitment", "definition": "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265589", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell fate commitment", "definition": "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265590", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation in dorsal spinal cord", "definition": "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265591", "aliases": [], "types": ["T043"], "canonical_name": "centriole-centriole cohesion", "definition": "The cell cycle process in which the two centrioles within a centrosome remain tightly paired. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265592", "aliases": ["mitotic exit", "exit from mitotic division"], "types": ["T043"], "canonical_name": "exit from mitosis", "definition": "The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265593", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of heart rate", "definition": "Any process that stops, prevents or reduces the frequency or rate of heart contraction. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265594", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of heart rate", "definition": "Any process that activates or increases the frequency or rate of heart contraction. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265595", "aliases": [], "types": ["T044"], "canonical_name": "light-activated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens in response to a light stimulus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265596", "aliases": [], "types": ["T043"], "canonical_name": "regulation of light-activated voltage-gated calcium channel activity", "definition": "Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265597", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell proliferation", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265598", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mesenchymal cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265599", "aliases": ["NGF receptor activity", "beta-nerve growth factor receptor activity"], "types": ["T044"], "canonical_name": "nerve growth factor receptor activity", "definition": "Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265600", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of peptidase activity", "definition": "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265601", "aliases": [], "types": ["T039"], "canonical_name": "regulation of receptor activity"}
{"concept_id": "C2265602", "aliases": [], "types": ["T039"], "canonical_name": "regulation of gastrulation", "definition": "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265603", "aliases": ["GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity"], "types": ["T044"], "canonical_name": "GDP-galactose:mannose-1-phosphate guanylyltransferase activity", "definition": "Catalysis of the reaction: GDP-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + alpha-L-galactose-1-phosphate. [MetaCyc:RXN4FS-12, PMID:17485667]"}
{"concept_id": "C2265604", "aliases": ["GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity"], "types": ["T044"], "canonical_name": "GDP-galactose:glucose-1-phosphate guanylyltransferase activity", "definition": "Catalysis of the reaction: GDP-L-galactose + alpha-D-glucose 1-phosphate = alpha-L-galactose-1-phosphate + GDP-alpha-D-glucose. [MetaCyc:RXN4FS-13, PMID:17485667]"}
{"concept_id": "C2265605", "aliases": [], "types": ["T044"], "canonical_name": "GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity", "definition": "Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol. [PMID:17485667]"}
{"concept_id": "C2265606", "aliases": ["GDP:glucose-1-phosphate guanyltransferase activity"], "types": ["T044"], "canonical_name": "glucose-1-phosphate guanylyltransferase (GDP) activity", "definition": "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose. [PMID:17462988]"}
{"concept_id": "C2265607", "aliases": ["GDP:galactose-1-phosphate guanyltransferase activity"], "types": ["T044"], "canonical_name": "galactose-1-phosphate guanylyltransferase (GDP) activity", "definition": "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose. [PMID:17462988]"}
{"concept_id": "C2265608", "aliases": ["gibberellin-mediated signalling"], "types": ["T044"], "canonical_name": "gibberellin mediated signaling pathway", "definition": "The series of molecular signals generated as a consequence of gibberellin stimulus. [PMID:17521411]"}
{"concept_id": "C2265609", "aliases": [], "types": ["T043"], "canonical_name": "response to sulfur dioxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus. [PMID:17425719]"}
{"concept_id": "C2265610", "aliases": [], "types": ["T044"], "canonical_name": "chlororespiration", "definition": "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool. [GOC:mtg_electron_transport, GOC:tb, PMID:17573537]"}
{"concept_id": "C2265611", "aliases": [], "types": ["T042"], "canonical_name": "stele development", "definition": "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds. [GOC:tb]"}
{"concept_id": "C2265612", "aliases": [], "types": ["T043"], "canonical_name": "microsporocyte differentiation", "definition": "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell. [CL:0000248, PMID:16751349]"}
{"concept_id": "C2265613", "aliases": [], "types": ["T043"], "canonical_name": "pollen mother cell differentiation"}
{"concept_id": "C2265614", "aliases": [], "types": ["T043"], "canonical_name": "epidermal cell division", "definition": "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells. [PMID:17450124]"}
{"concept_id": "C2265615", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epidermal cell division", "definition": "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis. [PMID:17450124]"}
{"concept_id": "C2265616", "aliases": [], "types": ["T039"], "canonical_name": "pollen tube reception", "definition": "Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells. [GOC:tb, PMID:17673660]"}
{"concept_id": "C2265617", "aliases": [], "types": ["T044"], "canonical_name": "H3 histone acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3. [EC:2.3.1.48]"}
{"concept_id": "C2265618", "aliases": [], "types": ["T044"], "canonical_name": "H4 histone acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. [EC:2.3.1.48]"}
{"concept_id": "C2265619", "aliases": ["manganese:hydrogen antiporter activity"], "types": ["T044"], "canonical_name": "manganese:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in). [PMID:17559518]"}
{"concept_id": "C2265620", "aliases": [], "types": ["T044"], "canonical_name": "thermospermine synthase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+. [EC:2.5.1.79, MetaCyc:RXN-11190, PMID:17560575]"}
{"concept_id": "C2265621", "aliases": [], "types": ["T044"], "canonical_name": "UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP. [PMID:17630273]"}
{"concept_id": "C2265622", "aliases": [], "types": ["T044"], "canonical_name": "UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity", "definition": "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose. [GOC:tair_curators, PMID:17190829]"}
{"concept_id": "C2265623", "aliases": [], "types": ["T044"], "canonical_name": "UDP-4-keto-rhamnose-4-keto-reductase activity", "definition": "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+. [GOC:tair_curators, PMID:17190829]"}
{"concept_id": "C2265624", "aliases": [], "types": ["T044"], "canonical_name": "UTP:arabinose-1-phosphate uridylyltransferase activity", "definition": "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate. [PMID:17341835]"}
{"concept_id": "C2265625", "aliases": [], "types": ["T039"], "canonical_name": "maintenance of shoot apical meristem identity", "definition": "The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. [GOC:dph, GOC:tb, PMID:17461786]"}
{"concept_id": "C2265626", "aliases": ["LE A biosynthetic process"], "types": ["T044"], "canonical_name": "Lewis a epitope biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-(1->4)[Gal-beta-(1->3)]GlcNAc) characteristic of plant protein N-linked oligosaccharides. [PMID:17630273]"}
{"concept_id": "C2265629", "aliases": [], "types": ["T043"], "canonical_name": "intercellular transport", "definition": "The movement of substances between cells. [GOC:dhl]"}
{"concept_id": "C2265630", "aliases": ["plasmodesma-mediated intercellular transport", "plasmodesmata-mediated cell-to-cell transport", "plasmodesma-mediated cell-to-cell transport"], "types": ["T043"], "canonical_name": "plasmodesmata-mediated intercellular transport", "definition": "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. [PMID:17601829]"}
{"concept_id": "C2265632", "aliases": ["proteasome-mediated protein catabolic process", "proteasome-mediated protein catabolism"], "types": ["T044"], "canonical_name": "proteasomal protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. [GOC:tb]"}
{"concept_id": "C2265633", "aliases": [], "types": ["T044"], "canonical_name": "proteasomal ubiquitin-independent protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin. [GOC:tb]"}
{"concept_id": "C2265634", "aliases": [], "types": ["T039"], "canonical_name": "transmitting tissue development", "definition": "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary. [PMID:17855426]"}
{"concept_id": "C2265635", "aliases": ["RNA duplex unwinding"], "types": ["T045"], "canonical_name": "RNA secondary structure unwinding", "definition": "The process in which a secondary structure of RNA are broken or 'melted'. [PMID:17169986]"}
{"concept_id": "C2265640", "aliases": [], "types": ["T043"], "definition": "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]", "canonical_name": "regulation of autophagy"}
{"concept_id": "C2265641", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of autophagy", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265642", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of autophagy", "definition": "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265643", "aliases": [], "types": ["T039"], "canonical_name": "polyamine homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of a polyamine. [GOC:dph, GOC:rph, GOC:tb, PMID:11161802, PMID:9761731]"}
{"concept_id": "C2265644", "aliases": [], "types": ["T044"], "canonical_name": "regulation of acetyl-CoA biosynthetic process from pyruvate", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265645", "aliases": [], "types": ["T040"], "canonical_name": "regulation of phosphatidylinositol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. [GOC:dph, GOC:tb, GOC:vw]"}
{"concept_id": "C2265646", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of phosphatidylinositol biosynthetic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. [GOC:dph, GOC:tb, GOC:vw]"}
{"concept_id": "C2265647", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of phosphatidylinositol biosynthetic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. [GOC:dph, GOC:tb, GOC:vw]"}
{"concept_id": "C2265648", "aliases": [], "types": ["T043"], "canonical_name": "induction of conjugation with cellular fusion", "definition": "The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265649", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of induction of conjugation with cellular fusion", "definition": "Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265650", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of cellular response to nitrogen starvation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular response to nitrogen starvation. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265651", "aliases": [], "types": ["T040"], "canonical_name": "regulation of phospholipase activity", "definition": "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2265652", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phospholipase activity", "definition": "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2265653", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phospholipase activity", "definition": "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2265655", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium ion transport into cytosol", "definition": "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265656", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of calcium ion transport into cytosol", "definition": "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265657", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of calcium ion transport into cytosol", "definition": "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265658", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transposition, RNA-mediated", "definition": "Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265659", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of transposition, RNA-mediated", "definition": "Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265660", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transposition, RNA-mediated", "definition": "Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265661", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transposition", "definition": "Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265662", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transposition", "definition": "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265663", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transposition", "definition": "Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265665", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine phosphorylation of JAK1 protein"}
{"concept_id": "C2265667", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of JAK1 protein"}
{"concept_id": "C2265668", "aliases": ["regulation of activation of JAK protein"], "types": ["T040"], "canonical_name": "regulation of activation of Janus kinase activity", "definition": "Any process that modulates the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. [GOC:dph, GOC:tb, PMID:17190829, PMID:9135582]"}
{"concept_id": "C2265669", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of JAK protein"}
{"concept_id": "C2265671", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tyrosine phosphorylation of JAK2 protein"}
{"concept_id": "C2265673", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of JAK2 protein"}
{"concept_id": "C2265674", "aliases": ["positive regulation of activation of JAK protein"], "types": ["T040"], "canonical_name": "positive regulation of activation of Janus kinase activity", "definition": "Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. [GOC:dph, GOC:tb, PMID:9135582]"}
{"concept_id": "C2265675", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of JAK protein"}
{"concept_id": "C2265677", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of JAK1 protein"}
{"concept_id": "C2265680", "aliases": [], "types": ["T043"], "canonical_name": "basipetal auxin transport", "definition": "The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root. [PMID:10677441]"}
{"concept_id": "C2265681", "aliases": [], "types": ["T043"], "canonical_name": "acropetal auxin transport", "definition": "The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root. [PMID:10677441]"}
{"concept_id": "C2265682", "aliases": [], "types": ["T044"], "canonical_name": "nitrate efflux transmembrane transporter activity", "definition": "Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane. [GOC:mah]"}
{"concept_id": "C2265683", "aliases": [], "types": ["T043"], "canonical_name": "regulation of platelet activation", "definition": "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2265684", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of platelet activation", "definition": "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2265687", "aliases": ["thylakoid membrane degradation"], "types": ["T043"], "canonical_name": "thylakoid membrane disassembly", "definition": "The controlled breakdown of the thylakoid membrane in the context of a normal process. [GOC:dph, GOC:tb, PMID:17416733]"}
{"concept_id": "C2265688", "aliases": ["regulation of thylakoid membrane degradation"], "types": ["T043"], "canonical_name": "regulation of thylakoid membrane disassembly", "definition": "Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly. [GOC:dph, GOC:tb, PMID:17416733]"}
{"concept_id": "C2265689", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane disassembly", "definition": "Any process that modulates the frequency, rate or extent of membrane disassembly. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265690", "aliases": ["regulation of LHCII degradation", "regulation of LHCII catabolism"], "types": ["T040"], "canonical_name": "regulation of PSII associated light-harvesting complex II catabolic process", "definition": "Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265691", "aliases": [], "types": ["T045"], "canonical_name": "regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C2265693", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C2265695", "aliases": ["response to mannitol stimulus"], "types": ["T043"], "canonical_name": "response to mannitol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus. [PMID:17999646]"}
{"concept_id": "C2265696", "aliases": [], "types": ["T044"], "canonical_name": "regulation of macromolecule biosynthetic process", "definition": "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265697", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of macromolecule biosynthetic process", "definition": "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265698", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of macromolecule biosynthetic process", "definition": "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265699", "aliases": [], "types": ["T040"], "canonical_name": "regulation of glycoprotein biosynthetic process", "definition": "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265700", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of glycoprotein biosynthetic process", "definition": "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265701", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of glycoprotein biosynthetic process", "definition": "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265702", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of phosphorus metabolic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265703", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of phosphorus metabolic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265705", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cellular ketone metabolic process", "definition": "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265706", "aliases": [], "types": ["T040"], "canonical_name": "regulation of ketone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265707", "aliases": [], "types": ["T040"], "canonical_name": "regulation of ketone catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2265709", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microglia differentiation"}
{"concept_id": "C2265710", "aliases": [], "types": ["T043"], "canonical_name": "activation of microglia differentiation"}
{"concept_id": "C2265711", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of microglia differentiation"}
{"concept_id": "C2265714", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of gliogenesis"}
{"concept_id": "C2265715", "aliases": [], "types": ["T039"], "canonical_name": "activation of gliogenesis"}
{"concept_id": "C2265716", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of gliogenesis"}
{"concept_id": "C2265719", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Schwann cell differentiation"}
{"concept_id": "C2265720", "aliases": [], "types": ["T043"], "canonical_name": "activation of Schwann cell differentiation"}
{"concept_id": "C2265721", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of Schwann cell differentiation"}
{"concept_id": "C2265723", "aliases": [], "types": ["T039"], "canonical_name": "activation of neuron maturation"}
{"concept_id": "C2265724", "aliases": [], "types": ["T039"], "canonical_name": "stimulation of neuron maturation"}
{"concept_id": "C2265727", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of neuron maturation"}
{"concept_id": "C2265728", "aliases": [], "types": ["T043"], "canonical_name": "activation of glutamate secretion"}
{"concept_id": "C2265729", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of glutamate secretion"}
{"concept_id": "C2265732", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glutamate secretion"}
{"concept_id": "C2265734", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gamma-aminobutyric acid secretion"}
{"concept_id": "C2265735", "aliases": [], "types": ["T043"], "canonical_name": "activation of gamma-aminobutyric acid secretion"}
{"concept_id": "C2265736", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of gamma-aminobutyric acid secretion"}
{"concept_id": "C2265738", "aliases": [], "types": ["T043"], "canonical_name": "activation of acetylcholine secretion"}
{"concept_id": "C2265739", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of acetylcholine secretion"}
{"concept_id": "C2265742", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of acetylcholine secretion"}
{"concept_id": "C2265744", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of serotonin secretion"}
{"concept_id": "C2265745", "aliases": [], "types": ["T043"], "canonical_name": "activation of serotonin secretion"}
{"concept_id": "C2265746", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of serotonin secretion"}
{"concept_id": "C2265750", "aliases": [], "types": ["T039"], "canonical_name": "activation of phosphoinositide 3-kinase cascade"}
{"concept_id": "C2265753", "aliases": ["response to organic cyclic substance"], "types": ["T043"], "canonical_name": "response to organic cyclic compound", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef]"}
{"concept_id": "C2265754", "aliases": [], "types": ["T043"], "canonical_name": "response to cycloalkane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n. [GOC:ef]"}
{"concept_id": "C2265755", "aliases": [], "types": ["T043"], "canonical_name": "response to isoquinoline alkaloid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. [GOC:ef]"}
{"concept_id": "C2265756", "aliases": [], "types": ["T043"], "canonical_name": "response to tropane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine. [GOC:ef]"}
{"concept_id": "C2265757", "aliases": [], "types": ["T043"], "canonical_name": "response to purine"}
{"concept_id": "C2265758", "aliases": ["response to amine stimulus"], "types": ["T043"], "canonical_name": "response to amine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. [GOC:ef]"}
{"concept_id": "C2265759", "aliases": [], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor. [GOC:ef, GOC:pr]", "canonical_name": "response to fluoxetine"}
{"concept_id": "C2265760", "aliases": [], "types": ["T026"], "canonical_name": "junctional sarcoplasmic reticulum membrane", "definition": "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane. [GOC:mtg_muscle]"}
{"concept_id": "C2265761", "aliases": [], "types": ["T026"], "canonical_name": "free sarcoplasmic reticulum membrane", "definition": "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane. [GOC:mtg_muscle]"}
{"concept_id": "C2265762", "aliases": [], "types": ["T039"], "canonical_name": "oscillatory muscle contraction", "definition": "A process in which force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation. [GOC:mtg_muscle]"}
{"concept_id": "C2265763", "aliases": [], "types": ["T026"], "canonical_name": "C zone", "definition": "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin. [GOC:mtg_muscle]"}
{"concept_id": "C2265765", "aliases": [], "types": ["T042"], "canonical_name": "branchiomeric skeletal muscle development", "definition": "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish. [GOC:mtg_muscle]"}
{"concept_id": "C2265766", "aliases": [], "types": ["T040"], "canonical_name": "regulation of somitomeric trunk muscle development", "definition": "Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development. [GOC:mtg_muscle]"}
{"concept_id": "C2265767", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of somitomeric trunk muscle development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. [GOC:mtg_muscle]"}
{"concept_id": "C2265768", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of somitomeric trunk muscle development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. [GOC:mtg_muscle]"}
{"concept_id": "C2265769", "aliases": [], "types": ["T040"], "canonical_name": "regulation of branchiomeric skeletal muscle development", "definition": "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. [GOC:mtg_muscle]"}
{"concept_id": "C2265770", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of branchiomeric skeletal muscle development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. [GOC:mtg_muscle]"}
{"concept_id": "C2265771", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of branchiomeric skeletal muscle development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. [GOC:mtg_muscle]"}
{"concept_id": "C2265772", "aliases": [], "types": ["T043"], "canonical_name": "myoblast fate commitment in head", "definition": "The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:mtg_muscle]"}
{"concept_id": "C2265773", "aliases": [], "types": ["T043"], "canonical_name": "myoblast fate commitment in trunk", "definition": "The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:mtg_muscle]"}
{"concept_id": "C2265774", "aliases": ["satellite cell asymmetric division involved in skeletal muscle regeneration"], "types": ["T043"], "canonical_name": "skeletal muscle satellite stem cell asymmetric division involved in skeletal muscle regeneration", "definition": "Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt. [GOC:mtg_muscle]"}
{"concept_id": "C2265775", "aliases": [], "types": ["T043"], "canonical_name": "regulation of satellite cell activation involved in skeletal muscle regeneration", "definition": "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. [GOC:mtg_muscle]"}
{"concept_id": "C2265776", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of satellite cell activation involved in skeletal muscle regeneration", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. [GOC:mtg_muscle]"}
{"concept_id": "C2265777", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle satellite cell activation", "definition": "The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. [GOC:mtg_muscle, PMID:23303905]"}
{"concept_id": "C2265778", "aliases": [], "types": ["T039"], "canonical_name": "tonic skeletal muscle contraction", "definition": "A process in which force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue. [GOC:mtg_muscle]"}
{"concept_id": "C2265779", "aliases": [], "types": ["T039"], "canonical_name": "twitch skeletal muscle contraction", "definition": "A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation. [GOC:mtg_muscle]"}
{"concept_id": "C2265780", "aliases": ["regulation of skeletal muscle contraction by calcium ion signalling"], "types": ["T040"], "canonical_name": "regulation of skeletal muscle contraction by calcium ion signaling", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction. [GOC:mtg_muscle]"}
{"concept_id": "C2265781", "aliases": ["regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction"], "types": ["T040"], "canonical_name": "regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril. [GOC:mtg_muscle]"}
{"concept_id": "C2265782", "aliases": [], "types": ["T040"], "canonical_name": "regulation of twitch skeletal muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction. [GOC:mtg_muscle]"}
{"concept_id": "C2265783", "aliases": [], "types": ["T040"], "canonical_name": "regulation of extraocular skeletal muscle development", "definition": "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. [GOC:mtg_muscle]"}
{"concept_id": "C2265784", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of extraocular skeletal muscle development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. [GOC:mtg_muscle]"}
{"concept_id": "C2265785", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of extraocular skeletal muscle development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. [GOC:mtg_muscle]"}
{"concept_id": "C2265786", "aliases": [], "types": ["T040"], "canonical_name": "regulation of the force of skeletal muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges. [GOC:mtg_muscle]"}
{"concept_id": "C2265787", "aliases": [], "types": ["T039"], "canonical_name": "regulation of the velocity of shortening of skeletal muscle modulating contraction", "definition": "Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres. [GOC:mtg_muscle]"}
{"concept_id": "C2265788", "aliases": [], "types": ["T042"], "canonical_name": "skeletal muscle regeneration at neuromuscular junction", "definition": "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers. [GOC:mtg_muscle]"}
{"concept_id": "C2265789", "aliases": [], "types": ["T026"], "canonical_name": "spectrin-associated cytoskeleton", "definition": "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane. [GOC:mtg_muscle, PMID:15970557]"}
{"concept_id": "C2265790", "aliases": [], "types": ["T039"], "canonical_name": "regulation of skeletal muscle adaptation", "definition": "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle]"}
{"concept_id": "C2265791", "aliases": [], "types": ["T039"], "canonical_name": "regulation of skeletal muscle plasticity"}
{"concept_id": "C2265792", "aliases": [], "types": ["T042"], "definition": "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. [GOC:mtg_muscle]", "canonical_name": "skeletal muscle hypertrophy"}
{"concept_id": "C2265793", "aliases": [], "types": ["T039"], "canonical_name": "regulation of muscle atrophy", "definition": "Any process that modulates the frequency, rate or extent of muscle atrophy. [GOC:mtg_muscle]"}
{"concept_id": "C2265794", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of muscle atrophy", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy. [GOC:mtg_muscle]"}
{"concept_id": "C2265795", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of muscle atrophy", "definition": "Any process that activates or increases the frequency, rate or extent of muscle atrophy. [GOC:mtg_muscle]"}
{"concept_id": "C2265796", "aliases": [], "types": ["T039"], "canonical_name": "regulation of muscle hyperplasia", "definition": "Any process that modulates the frequency, rate or extent of muscle hyperplasia. [GOC:mtg_muscle]"}
{"concept_id": "C2265797", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of muscle hyperplasia", "definition": "Any process that activates or increases the frequency, rate or extent of muscle hyperplasia. [GOC:mtg_muscle]"}
{"concept_id": "C2265798", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of muscle hyperplasia", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia. [GOC:mtg_muscle]"}
{"concept_id": "C2265799", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of muscle hypertrophy", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. [GOC:mtg_muscle]"}
{"concept_id": "C2265800", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of muscle hypertrophy", "definition": "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. [GOC:mtg_muscle]"}
{"concept_id": "C2265801", "aliases": [], "types": ["T039"], "canonical_name": "regulation of muscle hypertrophy", "definition": "Any process that modulates the frequency, rate or extent of muscle hypertrophy. [GOC:mtg_muscle]"}
{"concept_id": "C2265802", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of muscle adaptation", "definition": "Any process that activates or increases the frequency, rate or extent of muscle adaptation. [GOC:mtg_muscle]"}
{"concept_id": "C2265803", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of muscle plasticity"}
{"concept_id": "C2265804", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of muscle adaptation", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. [GOC:mtg_muscle]"}
{"concept_id": "C2265805", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of muscle plasticity"}
{"concept_id": "C2265806", "aliases": [], "types": ["T040"], "canonical_name": "regulation of tonic skeletal muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction. [GOC:mtg_muscle]"}
{"concept_id": "C2265807", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of tonic skeletal muscle contraction", "definition": "Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265808", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of tonic skeletal muscle contraction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of tonic skeletal muscle contraction. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265809", "aliases": [], "types": ["T026"], "canonical_name": "longitudinal sarcoplasmic reticulum", "definition": "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae. [GOC:mtg_muscle]"}
{"concept_id": "C2265810", "aliases": [], "types": ["T026"], "canonical_name": "terminal cisterna", "definition": "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release. [GOC:mtg_muscle]"}
{"concept_id": "C2265811", "aliases": [], "types": ["T026"], "canonical_name": "longitudinal sarcoplasmic reticulum lumen", "definition": "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae. [GOC:mtg_muscle]"}
{"concept_id": "C2265812", "aliases": [], "types": ["T026"], "canonical_name": "terminal cisterna lumen", "definition": "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin. [GOC:mtg_muscle]"}
{"concept_id": "C2265813", "aliases": [], "types": ["T039"], "canonical_name": "smooth muscle adaptation", "definition": "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle]"}
{"concept_id": "C2265814", "aliases": [], "types": ["T039"], "canonical_name": "smooth muscle plasticity"}
{"concept_id": "C2265815", "aliases": [], "types": ["T039"], "canonical_name": "smooth muscle hyperplasia", "definition": "A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ. [GOC:mtg_muscle]"}
{"concept_id": "C2265816", "aliases": [], "types": ["T039"], "canonical_name": "regulation of somitogenesis", "definition": "Any process that modulates the frequency, rate or extent of somitogenesis. [GOC:mtg_muscle]"}
{"concept_id": "C2265817", "aliases": ["release of sequestered calcium ion by sarcoplasmic reticulum into cytosol"], "types": ["T043"], "canonical_name": "release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "definition": "The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. [GOC:mtg_muscle]"}
{"concept_id": "C2265821", "aliases": [], "types": ["T043"], "canonical_name": "muscle cell migration", "definition": "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. [CL:0000187, GOC:mtg_muscle]"}
{"concept_id": "C2265822", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle satellite cell commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a satellite cell. [GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265823", "aliases": [], "types": ["T042"], "canonical_name": "axon regeneration at neuromuscular junction", "definition": "The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265824", "aliases": [], "types": ["T043"], "canonical_name": "initiation of skeletal muscle satellite cell activation by growth factor signaling, involved in skeletal muscle regeneration", "definition": "Signalling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. [GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265825", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle satellite cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a satellite cell. [GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265826", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle satellite cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265827", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle satellite cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265828", "aliases": [], "types": ["T040"], "canonical_name": "regulation of skeletal muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265829", "aliases": [], "types": ["T042"], "canonical_name": "tonic smooth muscle contraction", "definition": "A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction. [GOC:mtg_muscle]"}
{"concept_id": "C2265830", "aliases": [], "types": ["T042"], "canonical_name": "phasic smooth muscle contraction", "definition": "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. [GOC:mtg_muscle]"}
{"concept_id": "C2265831", "aliases": ["detection of injury"], "types": ["T043"], "canonical_name": "detection of wounding", "definition": "The series of events by which an injury stimulus is received and converted into a molecular signal. [GOC:mtg_muscle]"}
{"concept_id": "C2265832", "aliases": [], "types": ["T040"], "canonical_name": "response to activity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. [GOC:mtg_muscle]"}
{"concept_id": "C2265833", "aliases": [], "types": ["T040"], "canonical_name": "response to exercise"}
{"concept_id": "C2265834", "aliases": [], "types": ["T042"], "canonical_name": "artery smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart. [GOC:mtg_muscle, MA:0000708, MSH:D001158]"}
{"concept_id": "C2265835", "aliases": [], "types": ["T042"], "canonical_name": "stomach fundus smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch. [GOC:mtg_muscle, MA:0001612]"}
{"concept_id": "C2265836", "aliases": [], "types": ["T042"], "canonical_name": "vein smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds. [GOC:mtg_muscle, MA:0000715, MSH:D014680]"}
{"concept_id": "C2265837", "aliases": [], "types": ["T042"], "canonical_name": "intestine smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. [GOC:mtg_muscle, MA:0001539, MSH:D007422]"}
{"concept_id": "C2265838", "aliases": [], "types": ["T042"], "canonical_name": "distal stomach smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus. [GOC:mtg_muscle, PMID:30252381]"}
{"concept_id": "C2265839", "aliases": ["vascular associated smooth muscle contraction"], "types": ["T042"], "definition": "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. [GOC:mtg_muscle, MA:0002718]", "canonical_name": "vascular smooth muscle contraction"}
{"concept_id": "C2265840", "aliases": [], "types": ["T042"], "canonical_name": "arteriole smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries. [GOC:mtg_muscle, MA:0000706, MSH:D001160]"}
{"concept_id": "C2265841", "aliases": [], "types": ["T042"], "canonical_name": "gastro-intestinal system smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). [GOC:mtg_muscle, MA:0001523, MSH:D041981]"}
{"concept_id": "C2265842", "aliases": [], "types": ["T042"], "canonical_name": "urinary bladder smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract. [GOC:mr, GOC:mtg_muscle, PMID:11768524, PMID:18276178, PMID:538956]"}
{"concept_id": "C2265843", "aliases": ["satellite cell asymmetric division"], "types": ["T043"], "canonical_name": "skeletal muscle satellite stem cell asymmetric division", "definition": "The asymmetric division of a skeletal muscle satellite stem cell to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool. [GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265844", "aliases": ["satellite cell compartment self-renewal involved in skeletal muscle regeneration", "satellite cell population maintenance"], "types": ["T043"], "canonical_name": "skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration", "definition": "Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells. [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:23303905]"}
{"concept_id": "C2265845", "aliases": [], "types": ["T043"], "canonical_name": "satellite cell self-renewal"}
{"concept_id": "C2265846", "aliases": [], "types": ["T043"], "canonical_name": "myoblast differentiation involved in skeletal muscle regeneration", "definition": "The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265847", "aliases": [], "types": ["T043"], "canonical_name": "myoblast fate commitment involved in skeletal muscle regeneration", "definition": "The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265848", "aliases": [], "types": ["T043"], "canonical_name": "myoblast fate determination involved in skeletal muscle regeneration", "definition": "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265849", "aliases": [], "types": ["T043"], "canonical_name": "myoblast fate specification involved in skeletal muscle regeneration", "definition": "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265850", "aliases": [], "types": ["T043"], "canonical_name": "myoblast migration involved in skeletal muscle regeneration", "definition": "The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265851", "aliases": [], "types": ["T043"], "canonical_name": "mononucleate cell migration involved in skeletal muscle regeneration"}
{"concept_id": "C2265852", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle satellite cell proliferation", "definition": "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. [GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265853", "aliases": [], "types": ["T043"], "canonical_name": "regulation of skeletal muscle satellite cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation. [GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265854", "aliases": [], "types": ["T043"], "canonical_name": "growth factor dependent regulation of skeletal muscle satellite cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. [GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265855", "aliases": [], "types": ["T043"], "canonical_name": "myoblast proliferation involved in skeletal muscle regeneration", "definition": "The multiplication or reproduction of myoblasts, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]"}
{"concept_id": "C2265856", "aliases": [], "types": ["T042"], "canonical_name": "stomach body smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined. [GOC:ef, GOC:mtg_muscle, MA:0002559]"}
{"concept_id": "C2265857", "aliases": ["oesophagus smooth muscle contraction"], "types": ["T042"], "canonical_name": "esophagus smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract. [GOC:ef, GOC:mtg_muscle, MA:0001573, MSH:D041742]"}
{"concept_id": "C2265858", "aliases": [], "types": ["T042"], "canonical_name": "proximal stomach smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach. [GOC:mtg_muscle, PMID:30252381]"}
{"concept_id": "C2265859", "aliases": [], "types": ["T042"], "canonical_name": "urinary tract smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra. [GOC:ef, GOC:mtg_muscle, MA:0000325, MSH:D014551]"}
{"concept_id": "C2265860", "aliases": [], "types": ["T042"], "canonical_name": "ureter smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder. [GOC:mtg_muscle, MA:0000378]"}
{"concept_id": "C2265861", "aliases": [], "types": ["T040"], "canonical_name": "response to muscle activity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. [GOC:mtg_muscle]"}
{"concept_id": "C2265862", "aliases": [], "types": ["T040"], "canonical_name": "regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265863", "aliases": ["regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction"], "types": ["T043"], "canonical_name": "regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction", "definition": "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265864", "aliases": [], "types": ["T040"], "canonical_name": "response to inactivity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. [GOC:mtg_muscle]"}
{"concept_id": "C2265865", "aliases": [], "types": ["T043"], "canonical_name": "striated muscle cell proliferation", "definition": "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. [CL:0000737, GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265866", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle cell proliferation", "definition": "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. [CL:0000188, GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265867", "aliases": [], "types": ["T043"], "canonical_name": "regulation of skeletal muscle cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. [CL:0000188, GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265868", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of skeletal muscle cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. [CL:0000188, GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265869", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of skeletal muscle cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. [CL:0000188, GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265870", "aliases": ["neurotransmitter secretion involved in control of skeletal muscle contraction"], "types": ["T043"], "canonical_name": "neurotransmitter secretion involved in regulation of skeletal muscle contraction", "definition": "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. [GOC:dph, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2265871", "aliases": [], "types": ["T040"], "canonical_name": "regulation of skeletal muscle contraction via membrane action potential"}
{"concept_id": "C2265872", "aliases": [], "types": ["T040"], "canonical_name": "regulation of skeletal muscle contraction by chemo-mechanical energy conversion", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres. [GOC:mtg_muscle]"}
{"concept_id": "C2265873", "aliases": [], "types": ["T044"], "canonical_name": "detection of inactivity", "definition": "The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal. [GOC:mtg_muscle]"}
{"concept_id": "C2265874", "aliases": [], "types": ["T040"], "canonical_name": "detection of muscle activity", "definition": "The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal. [GOC:mtg_muscle]"}
{"concept_id": "C2265875", "aliases": [], "types": ["T044"], "canonical_name": "detection of activity", "definition": "The series of events in which an activity stimulus is received by a cell and converted into a molecular signal. [GOC:mtg_muscle]"}
{"concept_id": "C2265876", "aliases": [], "types": ["T042"], "canonical_name": "skeletal myofibril assembly", "definition": "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265877", "aliases": [], "types": ["T042"], "canonical_name": "cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction", "definition": "A process in which cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction. [GOC:mtg_muscle]"}
{"concept_id": "C2265878", "aliases": [], "types": ["T044"], "canonical_name": "detection of muscle inactivity", "definition": "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. [GOC:mtg_muscle]"}
{"concept_id": "C2265879", "aliases": [], "types": ["T040"], "canonical_name": "response to muscle inactivity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. [GOC:mtg_muscle]"}
{"concept_id": "C2265880", "aliases": [], "types": ["T042"], "canonical_name": "cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction", "definition": "The process in which actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction. [GOC:mtg_muscle]"}
{"concept_id": "C2265881", "aliases": [], "types": ["T043"], "canonical_name": "myoblast division", "definition": "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265882", "aliases": ["response to fatigue"], "types": ["T040"], "canonical_name": "response to muscle activity involved in regulation of muscle adaptation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265883", "aliases": [], "types": ["T040"], "canonical_name": "response to muscle activity involved in regulation of muscle plasticity"}
{"concept_id": "C2265884", "aliases": [], "types": ["T040"], "canonical_name": "response to stimulus involved in regulation of muscle adaptation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265885", "aliases": [], "types": ["T040"], "canonical_name": "response to stimulus involved in regulation of muscle plasticity"}
{"concept_id": "C2265886", "aliases": ["detection of fatigue"], "types": ["T044"], "canonical_name": "detection of muscle activity involved in regulation of muscle adaptation", "definition": "The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265887", "aliases": [], "types": ["T040"], "canonical_name": "response to injury involved in regulation of muscle adaptation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265888", "aliases": [], "types": ["T040"], "canonical_name": "response to injury involved in regulation of muscle plasticity"}
{"concept_id": "C2265889", "aliases": [], "types": ["T040"], "canonical_name": "response to muscle inactivity involved in regulation of muscle adaptation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265890", "aliases": [], "types": ["T040"], "canonical_name": "response to electrical stimulus involved in regulation of muscle adaptation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265891", "aliases": [], "types": ["T040"], "canonical_name": "response to electrical stimulus involved in regulation of muscle plasticity"}
{"concept_id": "C2265892", "aliases": [], "types": ["T039"], "canonical_name": "detection of electrical stimulus involved in regulation of muscle adaptation", "definition": "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265893", "aliases": [], "types": ["T040"], "canonical_name": "regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction. [GOC:dph, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2265894", "aliases": ["change of myofibril size"], "types": ["T039"], "canonical_name": "regulation of myofibril size", "definition": "Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2265895", "aliases": ["change of myofibril number"], "types": ["T039"], "canonical_name": "regulation of myofibril number", "definition": "Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2265896", "aliases": ["transition fast-slow fiber", "transition between fast and slow fibre", "transition fast-slow fibre"], "types": ["T039"], "canonical_name": "transition between fast and slow fiber", "definition": "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265897", "aliases": [], "types": ["T044"], "canonical_name": "detection of muscle inactivity involved in regulation of muscle adaptation", "definition": "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265898", "aliases": [], "types": ["T043"], "canonical_name": "detection of injury involved in regulation of muscle adaptation", "definition": "The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265899", "aliases": [], "types": ["T043"], "canonical_name": "detection of injury involved in regulation of muscle plasticity"}
{"concept_id": "C2265900", "aliases": ["transition slow-fast fibre", "transition between slow and fast fibre", "transition slow-fast fiber"], "types": ["T039"], "canonical_name": "transition between slow and fast fiber", "definition": "The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. [GOC:ef, GOC:mtg_muscle]"}
{"concept_id": "C2265901", "aliases": [], "types": ["T039"], "canonical_name": "cardiac muscle adaptation", "definition": "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. [GOC:mtg_muscle]"}
{"concept_id": "C2265902", "aliases": [], "types": ["T039"], "canonical_name": "cardiac muscle plasticity"}
{"concept_id": "C2265903", "aliases": [], "types": ["T039"], "canonical_name": "striated muscle adaptation", "definition": "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle]"}
{"concept_id": "C2265904", "aliases": [], "types": ["T039"], "canonical_name": "striated muscle plasticity"}
{"concept_id": "C2265905", "aliases": [], "types": ["T046"], "canonical_name": "smooth muscle atrophy", "definition": "A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. [GOC:mtg_muscle]"}
{"concept_id": "C2265906", "aliases": [], "types": ["T046"], "canonical_name": "striated muscle atrophy", "definition": "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. [GOC:mtg_muscle]"}
{"concept_id": "C2265907", "aliases": [], "types": ["T040"], "canonical_name": "response to rest involved in regulation of muscle adaptation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation. [GOC:mtg_muscle]"}
{"concept_id": "C2265908", "aliases": [], "types": ["T040"], "canonical_name": "response to denervation involved in regulation of muscle adaptation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation. [GOC:mtg_muscle]"}
{"concept_id": "C2265909", "aliases": [], "types": ["T046"], "canonical_name": "smooth muscle hypertrophy", "definition": "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. [GOC:mtg_muscle]"}
{"concept_id": "C2265910", "aliases": [], "types": ["T042"], "canonical_name": "striated muscle hypertrophy", "definition": "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. [GOC:mtg_muscle]"}
{"concept_id": "C2265911", "aliases": [], "types": ["T042"], "canonical_name": "cardiac muscle hypertrophy", "definition": "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. [GOC:mtg_heart]"}
{"concept_id": "C2265912", "aliases": [], "types": ["T046"], "canonical_name": "cardiac muscle atrophy", "definition": "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation. [GOC:mtg_muscle]"}
{"concept_id": "C2265913", "aliases": [], "types": ["T039"], "canonical_name": "muscle hyperplasia", "definition": "A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ. [GOC:mtg_muscle]"}
{"concept_id": "C2265914", "aliases": [], "types": ["T043"], "canonical_name": "satellite cell activation involved in skeletal muscle regeneration", "definition": "The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. [GOC:mtg_muscle]"}
{"concept_id": "C2265915", "aliases": [], "types": ["T043"], "canonical_name": "myotube differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:mtg_muscle]"}
{"concept_id": "C2265916", "aliases": [], "types": ["T043"], "canonical_name": "myotube cell development", "definition": "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:mtg_muscle]"}
{"concept_id": "C2265917", "aliases": [], "types": ["T042"], "canonical_name": "myoblast fusion involved in skeletal muscle regeneration", "definition": "A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:mtg_muscle]"}
{"concept_id": "C2265918", "aliases": [], "types": ["T043"], "canonical_name": "myotube cell development involved in skeletal muscle regeneration", "definition": "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:mtg_muscle]"}
{"concept_id": "C2265919", "aliases": [], "types": ["T043"], "canonical_name": "myotube differentiation involved in skeletal muscle regeneration", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:mtg_muscle]"}
{"concept_id": "C2265920", "aliases": [], "types": ["T043"], "canonical_name": "smooth muscle cell migration", "definition": "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism. [CL:0000192, GOC:mtg_muscle]"}
{"concept_id": "C2265921", "aliases": [], "types": ["T043"], "canonical_name": "regulation of smooth muscle cell migration", "definition": "Any process that modulates the frequency, rate or extent of smooth muscle cell migration. [CL:0000192, GOC:mtg_muscle]"}
{"concept_id": "C2265922", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of smooth muscle cell migration", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. [CL:0000192, GOC:mtg_muscle]"}
{"concept_id": "C2265923", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of smooth muscle cell migration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. [CL:0000192, GOC:mtg_muscle]"}
{"concept_id": "C2265924", "aliases": [], "types": ["T043"], "canonical_name": "myoblast maturation involved in muscle regeneration", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:mtg_muscle]"}
{"concept_id": "C2265925", "aliases": [], "types": ["T039"], "canonical_name": "regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction", "definition": "Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction. [GOC:dph, GOC:mtg_muscle, GOC:tb]"}
{"concept_id": "C2265926", "aliases": ["regulation of pulmonary blood pressure"], "types": ["T040"], "canonical_name": "regulation of lung blood pressure", "definition": "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:mtg_cardio]"}
{"concept_id": "C2265929", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme F430 metabolic process"}
{"concept_id": "C2265944", "aliases": [], "types": ["T044"], "canonical_name": "glucuronosyltransferase I activity"}
{"concept_id": "C2265949", "aliases": [], "types": ["T044"], "canonical_name": "1-naphthol glucuronyltransferase activity"}
{"concept_id": "C2265950", "aliases": [], "types": ["T044"], "canonical_name": "1-naphthol-UDP-glucuronosyltransferase activity"}
{"concept_id": "C2265951", "aliases": [], "types": ["T044"], "canonical_name": "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C2265952", "aliases": [], "types": ["T044"], "canonical_name": "17-OH steroid UDPGT activity"}
{"concept_id": "C2265953", "aliases": ["3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C2265954", "aliases": [], "types": ["T044"], "canonical_name": "3-OH androgenic UDPGT activity"}
{"concept_id": "C2265955", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxybiphenyl UDP-glucuronosyltransferase activity"}
{"concept_id": "C2265956", "aliases": [], "types": ["T044"], "canonical_name": "4-methylumbelliferone UDP-glucuronosyltransferase activity"}
{"concept_id": "C2265957", "aliases": ["4-nitrophenol UDPGT activity"], "types": ["T044"], "canonical_name": "4-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C2265959", "aliases": [], "types": ["T044"], "canonical_name": "bilirubin glucuronyltransferase activity"}
{"concept_id": "C2265960", "aliases": [], "types": ["T044"], "canonical_name": "bilirubin monoglucuronide glucuronyltransferase activity"}
{"concept_id": "C2265961", "aliases": ["bilirubin UDPGT activity"], "types": ["T044"], "canonical_name": "bilirubin UDP-glucuronosyltransferase activity"}
{"concept_id": "C2265962", "aliases": [], "types": ["T044"], "canonical_name": "bilirubin uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C2265963", "aliases": [], "types": ["T044"], "canonical_name": "ciramadol UDP-glucuronyltransferase activity"}
{"concept_id": "C2265964", "aliases": ["uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity", "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "estriol UDPglucuronosyltransferase activity"}
{"concept_id": "C2265965", "aliases": [], "types": ["T044"], "canonical_name": "estrone UDPglucuronosyltransferase activity"}
{"concept_id": "C2265967", "aliases": [], "types": ["T044"], "canonical_name": "morphine glucuronyltransferase activity"}
{"concept_id": "C2265968", "aliases": [], "types": ["T044"], "canonical_name": "p-hydroxybiphenyl UDP glucuronyltransferase activity"}
{"concept_id": "C2265969", "aliases": [], "types": ["T044"], "canonical_name": "p-nitrophenol UDP-glucuronosyltransferase activity"}
{"concept_id": "C2265970", "aliases": [], "types": ["T044"], "canonical_name": "p-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C2265971", "aliases": [], "types": ["T044"], "canonical_name": "p-nitrophenylglucuronosyltransferase activity"}
{"concept_id": "C2265972", "aliases": [], "types": ["T044"], "canonical_name": "p-phenylphenol glucuronyltransferase activity"}
{"concept_id": "C2265973", "aliases": [], "types": ["T044"], "canonical_name": "phenyl-UDP-glucuronosyltransferase activity"}
{"concept_id": "C2265974", "aliases": ["pnp-UDPGT activity"], "types": ["T044"], "canonical_name": "PNP-UDPGT"}
{"concept_id": "C2265976", "aliases": [], "types": ["T044"], "canonical_name": "UDP glucuronate-estradiol-glucuronosyltransferase activity"}
{"concept_id": "C2265977", "aliases": [], "types": ["T044"], "canonical_name": "UDP glucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C2265981", "aliases": ["uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C2265982", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucuronate-bilirubin glucuronyltransferase activity"}
{"concept_id": "C2265988", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"}
{"concept_id": "C2265991", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"}
{"concept_id": "C2265993", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity"}
{"concept_id": "C2265997", "aliases": [], "types": ["T044"], "canonical_name": "heparin-sulfate eliminase activity"}
{"concept_id": "C2265998", "aliases": [], "types": ["T044"], "canonical_name": "heparitinase I"}
{"concept_id": "C2265999", "aliases": [], "types": ["T044"], "canonical_name": "heparitinase II"}
{"concept_id": "C2266003", "aliases": [], "types": ["T044"], "canonical_name": "adrenodoxin reductase activity"}
{"concept_id": "C2266019", "aliases": [], "types": ["T044"], "canonical_name": "dinucleotide phosphate reductase activity"}
{"concept_id": "C2266022", "aliases": [], "types": ["T044"], "canonical_name": "rubredoxin--nicotinamide adenine activity"}
{"concept_id": "C2266037", "aliases": [], "types": ["T044"], "canonical_name": "ferric iron transmembrane transporter activity", "definition": "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. [ISBN:0198506732]"}
{"concept_id": "C2266038", "aliases": [], "types": ["T044"], "canonical_name": "ferrous iron transmembrane transporter activity", "definition": "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. [ISBN:0198506732]"}
{"concept_id": "C2266039", "aliases": [], "types": ["T044"], "canonical_name": "inorganic anion transmembrane transporter activity", "definition": "Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. [GOC:ai]"}
{"concept_id": "C2266040", "aliases": [], "types": ["T044"], "canonical_name": "sulfate permease activity"}
{"concept_id": "C2266041", "aliases": [], "types": ["T044"], "canonical_name": "thiosulfate permease activity"}
{"concept_id": "C2266042", "aliases": [], "types": ["T044"], "canonical_name": "canalicular bile acid transmembrane transporter activity", "definition": "The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:dph]"}
{"concept_id": "C2266043", "aliases": [], "types": ["T044"], "canonical_name": "oxaloacetate transmembrane transporter activity", "definition": "Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C2266044", "aliases": [], "types": ["T044"], "canonical_name": "fumarate transmembrane transporter activity", "definition": "Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. [GOC:ai]"}
{"concept_id": "C2266045", "aliases": [], "types": ["T044"], "canonical_name": "succinate transmembrane transporter activity", "definition": "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other. [ISBN:0198506732]"}
{"concept_id": "C2266046", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate transmembrane transporter activity", "definition": "Enables the transfer of carbohydrate from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266047", "aliases": [], "types": ["T044"], "canonical_name": "fucose transmembrane transporter activity", "definition": "Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266048", "aliases": [], "types": ["T044"], "canonical_name": "rhamnose transmembrane transporter activity", "definition": "Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. [GOC:ai, GOC:mtg_transport, ISBN:0815340729, RHEA:34995]"}
{"concept_id": "C2266049", "aliases": [], "types": ["T044"], "canonical_name": "oligosaccharide transmembrane transporter activity", "definition": "Enables the transfer of oligosaccharide from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266050", "aliases": [], "types": ["T044"], "canonical_name": "raffinose permease"}
{"concept_id": "C2266051", "aliases": [], "types": ["T044"], "canonical_name": "polysaccharide transmembrane transporter activity", "definition": "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266053", "aliases": [], "types": ["T044"], "canonical_name": "acidic amino acid transmembrane transporter activity", "definition": "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266054", "aliases": [], "types": ["T044"], "canonical_name": "aromatic amino acid transmembrane transporter activity", "definition": "Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266055", "aliases": ["basic amino acid permease activity"], "types": ["T044"], "canonical_name": "basic amino acid transmembrane transporter activity", "definition": "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266056", "aliases": [], "types": ["T044"], "canonical_name": "neutral amino acid transmembrane transporter activity", "definition": "Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266057", "aliases": [], "types": ["T044"], "canonical_name": "L-amino acid transmembrane transporter activity", "definition": "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266058", "aliases": [], "types": ["T044"], "canonical_name": "L-alanine transmembrane transporter activity", "definition": "Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C2266059", "aliases": [], "types": ["T044"], "canonical_name": "L-asparagine transmembrane transporter activity", "definition": "Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid. [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C2266060", "aliases": [], "types": ["T044"], "canonical_name": "L-aspartate transmembrane transporter activity", "definition": "Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid. [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C2266061", "aliases": [], "types": ["T044"], "canonical_name": "L-cystine transmembrane transporter activity", "definition": "Enables the transfer of L-cystine from one side of a membrane to the other. [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C2266063", "aliases": [], "types": ["T044"], "canonical_name": "glycine transmembrane transporter activity", "definition": "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. [GOC:ai]"}
{"concept_id": "C2266064", "aliases": [], "types": ["T044"], "canonical_name": "L-isoleucine transmembrane transporter activity", "definition": "Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266065", "aliases": [], "types": ["T044"], "canonical_name": "L-lysine permease"}
{"concept_id": "C2266066", "aliases": [], "types": ["T044"], "canonical_name": "L-leucine transmembrane transporter activity", "definition": "Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266067", "aliases": [], "types": ["T044"], "canonical_name": "L-methionine transmembrane transporter activity", "definition": "Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266068", "aliases": ["L-phenylalanine permease activity"], "types": ["T044"], "canonical_name": "L-phenylalanine transmembrane transporter activity", "definition": "Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266069", "aliases": [], "types": ["T044"], "canonical_name": "L-proline transmembrane transporter activity", "definition": "Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266070", "aliases": [], "types": ["T044"], "canonical_name": "L-serine transmembrane transporter activity", "definition": "Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266071", "aliases": [], "types": ["T044"], "canonical_name": "serine transporter activity"}
{"concept_id": "C2266072", "aliases": [], "types": ["T044"], "canonical_name": "L-threonine transmembrane transporter activity", "definition": "Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266073", "aliases": [], "types": ["T044"], "canonical_name": "methylammonium transmembrane transporter activity", "definition": "Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C2266074", "aliases": [], "types": ["T044"], "canonical_name": "urea transmembrane transporter activity", "definition": "Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2. [ISBN:0198506732]"}
{"concept_id": "C2266075", "aliases": [], "types": ["T044"], "canonical_name": "purine nucleoside transmembrane transporter activity", "definition": "Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C2266076", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine nucleoside transmembrane transporter activity", "definition": "Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C2266077", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme A transmembrane transporter activity", "definition": "Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [GOC:ai]"}
{"concept_id": "C2266078", "aliases": ["flavin adenine dinucleotide transmembrane transporter activity", "flavin-adenine dinucleotide transmembrane transporter activity"], "types": ["T044"], "canonical_name": "FAD transmembrane transporter activity", "definition": "Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. [ISBN:0198506732]"}
{"concept_id": "C2266079", "aliases": [], "types": ["T044"], "canonical_name": "pore activity"}
{"concept_id": "C2266080", "aliases": [], "types": ["T044"], "canonical_name": "pore class transporter activity"}
{"concept_id": "C2266081", "aliases": [], "types": ["T044"], "canonical_name": "sodium-dependent phosphate transmembrane transporter activity"}
{"concept_id": "C2266082", "aliases": [], "types": ["T044"], "canonical_name": "secondary active oligopeptide transmembrane transporter activity", "definition": "Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. [GOC:mtg_transport]"}
{"concept_id": "C2266083", "aliases": [], "types": ["T044"], "canonical_name": "peptide-acetyl-CoA secondary active transmembrane transporter activity", "definition": "Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]"}
{"concept_id": "C2266084", "aliases": [], "types": ["T044"], "canonical_name": "cystine secondary active transmembrane transporter activity", "definition": "Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]"}
{"concept_id": "C2266085", "aliases": ["high affinity glutamine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity glutamine transmembrane transporter activity", "definition": "Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport]"}
{"concept_id": "C2266086", "aliases": [], "types": ["T044"], "canonical_name": "zinc efflux active transmembrane transporter activity", "definition": "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force. [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3]"}
{"concept_id": "C2266088", "aliases": [], "types": ["T044"], "canonical_name": "sodium-independent organic anion transmembrane transporter activity", "definition": "Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators]"}
{"concept_id": "C2266089", "aliases": [], "types": ["T044"], "canonical_name": "thyroid hormone transmembrane transporter activity", "definition": "Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:ai]"}
{"concept_id": "C2266090", "aliases": [], "types": ["T044"], "canonical_name": "bilirubin secondary active transmembrane transporter activity", "definition": "Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]"}
{"concept_id": "C2266092", "aliases": [], "types": ["T044"], "canonical_name": "multidrug endosomal transmembrane transporter activity"}
{"concept_id": "C2266093", "aliases": [], "types": ["T044"], "canonical_name": "polyspecific organic cation transmembrane transporter activity"}
{"concept_id": "C2266094", "aliases": [], "types": ["T044"], "canonical_name": "secondary active monocarboxylate transmembrane transporter activity", "definition": "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. [GOC:bf, GOC:jl]"}
{"concept_id": "C2266097", "aliases": ["uridine:hydrogen ion symporter activity"], "types": ["T044"], "canonical_name": "uridine:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in). [GOC:mtg_transport]"}
{"concept_id": "C2266098", "aliases": [], "types": ["T044"], "canonical_name": "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity"}
{"concept_id": "C2266099", "aliases": [], "types": ["T044"], "canonical_name": "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity"}
{"concept_id": "C2266100", "aliases": ["high affinity secondary active ammonium transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity secondary active ammonium transmembrane transporter activity", "definition": "Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:mtg_transport]"}
{"concept_id": "C2266101", "aliases": [], "types": ["T044"], "canonical_name": "primary active transmembrane transporter activity", "definition": "Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources. [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-]"}
{"concept_id": "C2266102", "aliases": [], "types": ["T044"], "canonical_name": "primary active transporter"}
{"concept_id": "C2266103", "aliases": ["low affinity secondary active ammonium transmembrane transporter activity"], "types": ["T044"], "canonical_name": "low-affinity secondary active ammonium transmembrane transporter activity", "definition": "Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266104", "aliases": [], "types": ["T044"], "canonical_name": "low affinity ammonium transmembrane transporter activity"}
{"concept_id": "C2266113", "aliases": [], "types": ["T044"], "canonical_name": "ABC phosphate transporter activity"}
{"concept_id": "C2266118", "aliases": [], "types": ["T044"], "canonical_name": "oligopeptide permease activity"}
{"concept_id": "C2266123", "aliases": [], "types": ["T044"], "canonical_name": "histidine permease activity"}
{"concept_id": "C2266135", "aliases": [], "types": ["T044"], "canonical_name": "magnesium-translocating P-type ATPase activity"}
{"concept_id": "C2266140", "aliases": [], "types": ["T044"], "canonical_name": "decarboxylation-driven transporter"}
{"concept_id": "C2266141", "aliases": ["melibiose:monovalent cation symporter activity"], "types": ["T044"], "canonical_name": "melibiose:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in). [TC:2.A.2.1.1]"}
{"concept_id": "C2266142", "aliases": ["glucuronide:monovalent cation symporter activity"], "types": ["T044"], "canonical_name": "glucuronide:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in). [TC:2.A.2.3.1]"}
{"concept_id": "C2266143", "aliases": [], "types": ["T044"], "canonical_name": "putrescine transmembrane transporter activity", "definition": "Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. [GOC:ai]"}
{"concept_id": "C2266144", "aliases": [], "types": ["T044"], "canonical_name": "cadaverine transmembrane transporter activity"}
{"concept_id": "C2266145", "aliases": ["cytosine:hydrogen ion symporter activity"], "types": ["T044"], "canonical_name": "cytosine:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in). [TC:2.A.39.1.1]"}
{"concept_id": "C2266146", "aliases": [], "types": ["T044"], "canonical_name": "uracil:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in). [GOC:mtg_transport]"}
{"concept_id": "C2266148", "aliases": ["xanthosine:hydrogen ion symporter activity"], "types": ["T044"], "canonical_name": "xanthosine:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in). [TC:2.A.1.10.2]"}
{"concept_id": "C2266150", "aliases": [], "types": ["T044"], "canonical_name": "hexuronate:cation symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate. [TC:2.A.1.14.2]"}
{"concept_id": "C2266151", "aliases": ["3-hydroxyphenyl propionate:hydrogen ion symporter activity"], "types": ["T043"], "canonical_name": "3-hydroxyphenyl propionate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in). [TC:2.A.1.15.2]"}
{"concept_id": "C2266154", "aliases": [], "types": ["T044"], "canonical_name": "phenyl propionate uniporter activity", "definition": "Enables the transfer of phenyl propionate from one side of a membrane to the other. [GOC:mtg_transport, TC:2.A.1.27.1]"}
{"concept_id": "C2266155", "aliases": [], "types": ["T044"], "canonical_name": "tartrate transmembrane transporter activity", "definition": "Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria. [GOC:ai]"}
{"concept_id": "C2266156", "aliases": [], "types": ["T044"], "canonical_name": "C4-dicarboxylate transmembrane transporter activity", "definition": "Enables the transfer of C4-dicarboxylate from one side of a membrane to the other. [GOC:krc]"}
{"concept_id": "C2266159", "aliases": [], "types": ["T044"], "canonical_name": "threonine export protein"}
{"concept_id": "C2266161", "aliases": ["D-GlcNAc transmembrane transporter activity", "N-acetyl-D-glucosamine transmembrane transporter activity", "N-acetylchitosamine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "N-acetylglucosamine transmembrane transporter activity", "definition": "Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266162", "aliases": [], "types": ["T044"], "canonical_name": "N-Acetyl-D-glucosamine permease"}
{"concept_id": "C2266163", "aliases": [], "types": ["T044"], "canonical_name": "methylgalactoside transmembrane transporter activity", "definition": "Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266164", "aliases": [], "types": ["T044"], "canonical_name": "allose transmembrane transporter activity", "definition": "Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2266165", "aliases": [], "types": ["T044"], "canonical_name": "iron chelate transmembrane transporter activity", "definition": "Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions. [PMID:17660286]"}
{"concept_id": "C2266166", "aliases": [], "types": ["T044"], "canonical_name": "spermidine transmembrane transporter activity", "definition": "Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C2266167", "aliases": [], "types": ["T044"], "canonical_name": "ferric-enterobactin transmembrane transporter activity", "definition": "Enables the transfer of ferric-enterobactin from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C2266168", "aliases": [], "types": ["T044"], "canonical_name": "ferric-hydroxamate transmembrane transporter activity"}
{"concept_id": "C2266170", "aliases": [], "types": ["T044"], "canonical_name": "L-diaminopimelate transmembrane transporter activity", "definition": "Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid. [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]"}
{"concept_id": "C2266171", "aliases": ["general secretion pathway-associated complex location"], "types": ["T026"], "canonical_name": "general secretion pathway-associated complex"}
{"concept_id": "C2266172", "aliases": ["type II protein secretion system complex location", "MTB", "main terminal branch", "T2SS-associated complexes"], "types": ["T026"], "definition": "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. [PMID:16448494]", "canonical_name": "type II protein secretion system complex"}
{"concept_id": "C2266173", "aliases": ["Sec-dependent secretion system-associated complex location"], "types": ["T026"], "canonical_name": "Sec-dependent secretion system-associated complex"}
{"concept_id": "C2266175", "aliases": ["zinc-transporting ATPase activity", "zinc transporting ATPase activity", "ATP-dependent zinc transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled zinc transmembrane transporter activity"}
{"concept_id": "C2266177", "aliases": ["fatty acid CoA ligase activity", "fatty acyl-coenzyme A synthetase activity", "fatty-acid ligase activity"], "types": ["T044"], "canonical_name": "fatty acid ligase activity", "definition": "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. [GOC:cjk, GOC:mah]"}
{"concept_id": "C2266183", "aliases": ["nicotinamide ribonucleotide transmembrane transporter activity"], "types": ["T044"], "canonical_name": "nicotinamide mononucleotide transmembrane transporter activity", "definition": "Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP. [ISBN:0721662544]"}
{"concept_id": "C2266184", "aliases": [], "types": ["T044"], "canonical_name": "alcohol transmembrane transporter activity", "definition": "Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. [ISBN:0198506732]"}
{"concept_id": "C2266193", "aliases": [], "types": ["T043"], "canonical_name": "magnesium transport"}
{"concept_id": "C2266195", "aliases": [], "types": ["T043"], "canonical_name": "bile acid and bile salt transport", "definition": "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511]"}
{"concept_id": "C2266196", "aliases": [], "types": ["T043"], "canonical_name": "bile salt transport"}
{"concept_id": "C2266199", "aliases": [], "types": ["T044"], "canonical_name": "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity"}
{"concept_id": "C2266215", "aliases": ["rhodopsin mediated signalling pathway", "rhodopsin signaling", "rhodopsin mediated phototransduction"], "types": ["T043"], "canonical_name": "rhodopsin mediated signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by the excitation of rhodopsin by a photon, and ending with the regulation of a downstream cellular process. [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb]"}
{"concept_id": "C2266252", "aliases": [], "types": ["T044"], "canonical_name": "cellobiohydrolase I"}
{"concept_id": "C2266260", "aliases": [], "types": ["T044"], "canonical_name": "carotene oxidase activity"}
{"concept_id": "C2266267", "aliases": [], "types": ["T044"], "canonical_name": "dual oxidase activity"}
{"concept_id": "C2266269", "aliases": [], "types": ["T044"], "canonical_name": "p138tox"}
{"concept_id": "C2266270", "aliases": ["thyroid oxidase activity"], "types": ["T044"], "canonical_name": "ThOX activity"}
{"concept_id": "C2266271", "aliases": [], "types": ["T044"], "canonical_name": "THOX2 activity"}
{"concept_id": "C2266272", "aliases": [], "types": ["T044"], "canonical_name": "thyroid oxidase 2 activity"}
{"concept_id": "C2266273", "aliases": [], "types": ["T043"], "canonical_name": "vesicle trafficking"}
{"concept_id": "C2266276", "aliases": [], "types": ["T044"], "canonical_name": "MB-COMT (membrane-bound form of catechol-O-methyltransferase)"}
{"concept_id": "C2266301", "aliases": ["kynurenine aminotransferase activity", "L-kynurenine transaminase activity"], "types": ["T044"], "canonical_name": "kynurenine aminotransferase activity", "definition": "Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid. [EC:2.6.1.-, GOC:pde]"}
{"concept_id": "C2266322", "aliases": [], "types": ["T043"], "canonical_name": "activation of macroautophagy"}
{"concept_id": "C2266323", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of macroautophagy"}
{"concept_id": "C2266326", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of macroautophagy"}
{"concept_id": "C2266338", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea"}
{"concept_id": "C2266339", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea"}
{"concept_id": "C2266341", "aliases": [], "types": ["T044"], "canonical_name": "myelin basic protein methylase I"}
{"concept_id": "C2266357", "aliases": [], "types": ["T044"], "canonical_name": "fatty acyl thioesterase I"}
{"concept_id": "C2266362", "aliases": [], "types": ["T044"], "canonical_name": "palmityl thioesterase I"}
{"concept_id": "C2266366", "aliases": [], "types": ["T044"], "canonical_name": "type I phosphatidylinositol kinase activity"}
{"concept_id": "C2266367", "aliases": [], "types": ["T044"], "canonical_name": "type III phosphoinositide 3-kinase activity"}
{"concept_id": "C2266369", "aliases": [], "types": ["T044"], "canonical_name": "diphosphoinositide kinase activity"}
{"concept_id": "C2266370", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol 4-phosphate kinase activity"}
{"concept_id": "C2266372", "aliases": [], "types": ["T044"], "canonical_name": "PIP kinase activity"}
{"concept_id": "C2266374", "aliases": [], "types": ["T044"], "canonical_name": "type I PIP kinase activity"}
{"concept_id": "C2266376", "aliases": [], "types": ["T044"], "canonical_name": "type II PIP kinase activity"}
{"concept_id": "C2266381", "aliases": ["inositol polyphosphate 4-phosphatase type II activity"], "types": ["T044"], "canonical_name": "inositol polyphosphate 4-phosphatase type II activity"}
{"concept_id": "C2266395", "aliases": [], "types": ["T044"], "canonical_name": "NRH:quinone oxidoreductase 2 activity"}
{"concept_id": "C2266396", "aliases": ["quinone reductase 2 activity"], "types": ["T044"], "canonical_name": "QR2 activity"}
{"concept_id": "C2266401", "aliases": ["CTP(ATP):tRNA nucleotidyltransferase"], "types": ["T045"], "canonical_name": "CTP(ATP):tRNA nucleotidyltransferase"}
{"concept_id": "C2266409", "aliases": ["peptide-methionine (R)-S-oxide reductase activity", "methionine S-oxide reductase (R-form oxidizing) activity", "PilB", "peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity", "pMRsr", "SelX", "protein-methionine-R-oxide reductase activity", "pMSR", "SelR"], "types": ["T044"], "definition": "Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]", "canonical_name": "MsrB"}
{"concept_id": "C2266410", "aliases": ["7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity", "7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity", "HCO 12alpha-hydroxylase activity", "7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+). [PMID:10051404, PMID:1400444, RHEA:46752]", "canonical_name": "CYP12"}
{"concept_id": "C2266411", "aliases": ["taurochenodeoxycholate 6alpha-monooxygenase activity", "taurochenodeoxycholate 6alpha-hydroxylase activity", "CYP4A21", "CYP3A4"], "types": ["T044"], "definition": "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O. [RHEA:23644]", "canonical_name": "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity"}
{"concept_id": "C2266412", "aliases": ["GALK2", "N-acetylgalactosamine kinase activity", "GK2", "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity", "GalNAc kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate. [EC:2.7.1.157]", "canonical_name": "ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity"}
{"concept_id": "C2266413", "aliases": ["STK10", "ATP:Fas-activated serine/threonine protein phosphotransferase activity", "Fas-activated serine/threonine kinase activity", "FAST"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein. [EC:2.7.11.8]", "canonical_name": "FASTK"}
{"concept_id": "C2266414", "aliases": ["HSL", "diacylglycerol acylhydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate. [EC:3.1.1.79]", "canonical_name": "hormone-sensitive lipase activity"}
{"concept_id": "C2266415", "aliases": ["PAP", "polyphosphate:AMP phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP. [PMID:11237733]", "canonical_name": "PPT"}
{"concept_id": "C2266416", "aliases": ["succinyl ornithine transaminase activity", "SOAT", "N(2)-succinylornithine 5-aminotransferase activity", "N2-succinylornithine 5-aminotransferase activity", "2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity", "N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity", "succinylornithine transaminase activity", "AstC"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate. [EC:2.6.1.81, RHEA:16953]", "canonical_name": "succinyl-ornithine transaminase activity"}
{"concept_id": "C2266417", "aliases": ["TAD1", "tRNA-specific adenosine-37 deaminase activity", "tRNA(Ala)-A37 deaminase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule. [PMID:8915538, PMID:9707437]", "canonical_name": "tRNA-specific adenosine deaminase 1"}
{"concept_id": "C2266609", "aliases": ["indoleamine 2,3-dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine. [EC:1.13.11.52]", "canonical_name": "IDO"}
{"concept_id": "C2266610", "aliases": ["ceramide:phosphatidylcholine cholinephosphotransferase activity", "SMS2", "SM synthase activity", "sphingomyelin synthase activity", "phosphatidylcholine:ceramide cholinephosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. [EC:2.7.8.27, RHEA:18765]", "canonical_name": "SMS1"}
{"concept_id": "C2266615", "aliases": ["CO-methylating acetyl-CoA synthase activity", "acetyl-CoA:corrinoid protein O-acetyltransferase activity", "ACS", "CO-methylating acetyl-coenzyme A synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA. [EC:2.3.1.169, PMID:1748656]", "canonical_name": "acetyl-CoA synthase activity"}
{"concept_id": "C2266617", "aliases": ["diphosphoinositol-pentakisphosphate kinase activity", "PP-InsP5 kinase activity", "VIP2", "VIP1", "PPIP5K", "ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate. [EC:2.7.4.24]", "canonical_name": "PP-IP5 kinase activity"}
{"concept_id": "C2266618", "aliases": ["(+)-(10R)-germacrene A synthase activity", "germacrene A synthase activity", "GAS", "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity", "(+)-germacrene A synthase activity", "germacrene-A synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate. [EC:4.2.3.23, RHEA:12516]", "canonical_name": "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity"}
{"concept_id": "C2266625", "aliases": ["6'-aminoglycoside-N-acetyltransferase activity", "kanamycin 6'-N-acetyltransferase activity", "AAC(6') activity", "aminoglycoside-6'-acetyltransferase activity", "aminoglycoside N6'-acetyltransferase activity", "aminoglycoside-6-N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "aminoglycoside 6'-N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H(+). This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring. [EC:2.3.1.82, RHEA:16449]"}
{"concept_id": "C2266763", "aliases": [], "types": ["T044"], "canonical_name": "PabB activity"}
{"concept_id": "C2266771", "aliases": ["FMO5", "FMO-II", "FMO1", "FMO2", "FMO-I", "FMO4", "flavin-containing monooxygenase activity"], "types": ["T044"], "canonical_name": "FMO3"}
{"concept_id": "C2266794", "aliases": ["formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)", "pyruvate formate-lyase-activating enzyme", "[formate-C-acetyltransferase]-activating enzyme activity", "[pyruvate formate-lyase]-activating enzyme activity", "PFL activase activity", "formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity", "formate acetyltransferase activating enzyme activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical. [EC:1.97.1.4, GOC:jl, PMID:18307109]", "canonical_name": "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity"}
{"concept_id": "C2266799", "aliases": ["TMA methyltransferase 1", "mttB1", "MT1", "trimethylamine methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine. [PMID:9006042]", "canonical_name": "trimethylamine:corrinoid methyltransferase activity"}
{"concept_id": "C2266800", "aliases": ["mtbB1", "MT1", "DMAMT 1", "DMA methyltransferase 1", "dimethylamine:corrinoid methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine. [PMID:9874228]", "canonical_name": "dimethylamine methyltransferase activity"}
{"concept_id": "C2266806", "aliases": ["[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity", "methylamine-specific methylcobalamin:CoM methyltransferase activity", "methylamine-specific methylcobalamin:coenzyme M methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H+ + methyl-coenzyme M. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M. [RHEA:18773]", "canonical_name": "MT2-A"}
{"concept_id": "C2266809", "aliases": ["acireductone synthase activity", "E-1"], "types": ["T044"], "definition": "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. [EC:3.1.3.77, RHEA:21700]", "canonical_name": "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)"}
{"concept_id": "C2266810", "aliases": ["phosphonopyruvate hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 3-phosphonopyruvate + H(2)O = phosphate + pyruvate. [EC:3.11.1.3, RHEA:16673]", "canonical_name": "PPH"}
{"concept_id": "C2314861", "aliases": ["GA", "cephalosporin C acylase activity", "glutaryl-7-aminocephalosporanic acid acylase activity", "GCA", "(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity", "glutaryl-7-ACA acylase activity", "GL-7-ACA acylase activity", "CA", "glutaryl-7-aminocephalosporanic-acid acylase activity", "cephalosporin acylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate. [EC:3.5.1.93]", "canonical_name": "7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity"}
{"concept_id": "C2324468", "aliases": [], "types": ["T026"], "definition": "A ribosome bound to mRNA that forms part of a polysome. [GOC:jl]", "canonical_name": "polysomal ribosome"}
{"concept_id": "C2327977", "aliases": ["axoplasm"], "types": ["T026"], "definition": "Any cytoplasm that is part of a axon. [GO_REF:0000064, GOC:TermGenie, PMID:18667152]", "canonical_name": "axon cytoplasm"}
{"concept_id": "C2335800", "aliases": ["plasma membrane region"], "types": ["T029"], "definition": "A membrane that is a (regional) part of the plasma membrane. [GOC:dos]", "canonical_name": "region of plasma membrane"}
{"concept_id": "C2336600", "aliases": ["mitochondrial protein complex"], "types": ["T026"], "canonical_name": "mitochondrial protein complex location"}
{"concept_id": "C2349946", "aliases": ["inositol 1,3,4,5-tetrakisphosphate 6-kinase activity", "1D-myo-inositol-tetrakisphosphate 6-kinase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. [GOC:elh]", "canonical_name": "inositol tetrakisphosphate 6-kinase activity"}
{"concept_id": "C2350307", "aliases": ["microvesicle", "ectosome"], "types": ["T026"], "definition": "Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.", "canonical_name": "extracellular microvesicle"}
{"concept_id": "C2350332", "aliases": ["extracellular exosome", "extracellular vesicular exosome"], "types": ["T026"], "definition": "A type of extracellular vesicle, containing RNA and proteins, that is secreted into the extracellular space by EXOCYTOSIS when MULTIVESICULAR BODIES fuse with the PLASMA MEMBRANE.", "canonical_name": "exosome"}
{"concept_id": "C2350405", "aliases": [], "types": ["T067"], "definition": "The assembly of the QUATERNARY PROTEIN STRUCTURE of multimeric proteins (MULTIPROTEIN COMPLEXES) from their composite PROTEIN SUBUNITS.", "canonical_name": "protein multimerization"}
{"concept_id": "C2350407", "aliases": ["protein trimer assembly", "protein trimer formation", "protein trimer biosynthetic process", "protein trimer biosynthesis"], "types": ["T067"], "definition": "The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. [GOC:hjd]", "canonical_name": "protein trimerization"}
{"concept_id": "C2350423", "aliases": ["Gemini of coiled bodies"], "types": ["T026"], "definition": "Small, punctate nuclear structures found in close proximity to COILED BODIES. They are enriched with SMN COMPLEX PROTEINS and may play a role in the processing of SMALL NUCLEAR RIBONUCLEOPROTEINS.", "canonical_name": "Gems"}
{"concept_id": "C2350522", "aliases": ["sensory perception of touch", "perception of touch", "tactile sense", "tactition"], "types": ["T041"], "definition": "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). [GOC:ai]", "canonical_name": "taction"}
{"concept_id": "C2350989", "aliases": ["bone mineralization"], "types": ["T042"], "definition": "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354]", "canonical_name": "bone calcification"}
{"concept_id": "C2608037", "aliases": [], "types": ["T044"], "canonical_name": "endo-1,3-beta-glucanase activity"}
{"concept_id": "C2608097", "aliases": ["maintenance of oocyte nucleus location involved in oocyte dorsal-ventral axis specification", "maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis determination", "maintenance of oocyte nucleus location involved in oocyte dorsoventral axis specification"], "types": ["T043"], "canonical_name": "maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification", "definition": "Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster. [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C2608098", "aliases": ["oocyte nucleus localization involved in oocyte dorsal-ventral axis specification", "oocyte nucleus localization during oocyte axis determination", "establishment and maintenance of oocyte nucleus localization during oocyte axis determination", "oocyte axis determination, oocyte nucleus localization", "oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification", "oocyte nucleus localization involved in oocyte dorsoventral axis specification", "oocyte nucleus localization involved in oocyte dorsal/ventral axis determination"], "types": ["T043"], "canonical_name": "oocyte nucleus localization involved in oocyte dorsal/ventral axis specification", "definition": "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb]"}
{"concept_id": "C2608099", "aliases": ["heart muscle morphogenesis"], "types": ["T042"], "canonical_name": "cardiac muscle tissue morphogenesis", "definition": "The process in which the anatomical structures of cardiac muscle tissue are generated and organized. [GOC:devbiol]"}
{"concept_id": "C2608100", "aliases": [], "types": ["T043"], "canonical_name": "oocyte nucleus migration during oocyte axis specification"}
{"concept_id": "C2610186", "aliases": ["nuclear mRNA cis splicing, via U2-type spliceosome", "nuclear mRNA cis splicing, via spliceosome", "splicing"], "types": ["T045"], "definition": "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. [GOC:krc, ISBN:0879695897, PMID:18458335]", "canonical_name": "mRNA cis splicing, via spliceosome"}
{"concept_id": "C2610187", "aliases": ["regulation of cell redox homeostasis"], "types": ["T043"], "canonical_name": "regulation of redox homeostasis"}
{"concept_id": "C2610193", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of flagellum assembly"}
{"concept_id": "C2610195", "aliases": [], "types": ["T043"], "canonical_name": "cell regulatory volume decrease"}
{"concept_id": "C2610196", "aliases": [], "types": ["T040"], "canonical_name": "female receptivity"}
{"concept_id": "C2610197", "aliases": ["detection of hypoxic conditions in blood by chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of hypoxic conditions in blood by chemoreceptor signaling", "definition": "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. [GOC:dph]"}
{"concept_id": "C2610198", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell adhesion involved in intussusceptive angiogenesis", "definition": "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis. [PMID:16391003]"}
{"concept_id": "C2610203", "aliases": [], "types": ["T043"], "canonical_name": "muscle cell cellular homeostasis", "definition": "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. [GOC:mah, PMID:3091429, PMID:7781901]"}
{"concept_id": "C2610204", "aliases": ["phosphatidylinositol phosphate biosynthesis", "PtdInsP biosynthesis", "PIP biosynthesis"], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. [ISBN:0198506732]"}
{"concept_id": "C2610205", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphate phosphorylation"}
{"concept_id": "C2610208", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphate catabolic process"}
{"concept_id": "C2610209", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphate dephosphorylation"}
{"concept_id": "C2610210", "aliases": [], "types": ["T044"], "canonical_name": "PIP catabolism"}
{"concept_id": "C2610211", "aliases": [], "types": ["T044"], "canonical_name": "PtdInsP catabolism"}
{"concept_id": "C2610212", "aliases": [], "types": ["T044"], "canonical_name": "PtdInsP dephosphorylation"}
{"concept_id": "C2610216", "aliases": ["SOCE", "store-operated calcium import", "capacitative calcium entry"], "types": ["T043"], "canonical_name": "store-operated calcium entry", "definition": "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. [GOC:hjd, PMID:11120592, PMID:17956991]"}
{"concept_id": "C2610217", "aliases": ["calcium ion uptake", "calcium ion import"], "types": ["T043"], "canonical_name": "calcium ion import", "definition": "The directed movement of calcium ions into a cell or organelle. [GOC:mah]"}
{"concept_id": "C2610218", "aliases": ["plexin-neurophilin complex location", "plexin-neurophilin complex", "semaphorin receptor complex location"], "types": ["T026"], "canonical_name": "semaphorin receptor complex", "definition": "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544]"}
{"concept_id": "C2610220", "aliases": ["inter-male aggression"], "types": ["T055"], "canonical_name": "inter-male aggressive behavior", "definition": "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious. [GOC:hjd]"}
{"concept_id": "C2610221", "aliases": ["fear-induced aggression"], "types": ["T055"], "canonical_name": "fear-induced aggressive behavior", "definition": "Aggressive behavior associated with attempts to flee from a threat. [GOC:hjd]"}
{"concept_id": "C2610222", "aliases": ["irritable aggression"], "types": ["T055"], "canonical_name": "irritable aggressive behavior", "definition": "Aggressive behavior induced by frustration and directed against an available target. [GOC:hjd]"}
{"concept_id": "C2610223", "aliases": ["maternal aggression"], "types": ["T055"], "definition": "Aggressive behavior of a female to protect her offspring from a threat. [GOC:hjd]", "canonical_name": "maternal aggressive behavior"}
{"concept_id": "C2610224", "aliases": ["instrumental aggression"], "types": ["T055"], "canonical_name": "instrumental aggressive behavior", "definition": "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation. [GOC:hjd]"}
{"concept_id": "C2610225", "aliases": ["wobble position m5C biosynthesis"], "types": ["T045"], "canonical_name": "tRNA wobble base cytosine methylation", "definition": "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C2610226", "aliases": [], "types": ["T045"], "canonical_name": "tRNA nucleoside ribose methylation", "definition": "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C2610227", "aliases": [], "types": ["T045"], "canonical_name": "wobble position guanine ribose methylation", "definition": "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C2610228", "aliases": [], "types": ["T045"], "canonical_name": "wobble position ribose methylation", "definition": "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C2610229", "aliases": [], "types": ["T045"], "canonical_name": "wobble position cytosine ribose methylation", "definition": "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C2610230", "aliases": [], "types": ["T045"], "canonical_name": "wobble position uridine ribose methylation", "definition": "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C2610231", "aliases": ["polycystin complex location"], "types": ["T026"], "canonical_name": "polycystin complex", "definition": "A stable heterodimeric complex composed of polycystin-1 and polycystin-2. [GOC:hjd, PMID:11901144]"}
{"concept_id": "C2610232", "aliases": [], "types": ["T044"], "canonical_name": "UTP binding", "definition": "Binding to UTP, uridine 5'-triphosphate. [GOC:hjd, ISBN:0198506732]"}
{"concept_id": "C2610233", "aliases": [], "types": ["T044"], "canonical_name": "CTP binding", "definition": "Binding to CTP, cytidine 5'-triphosphate. [GOC:hjd, ISBN:0124020607]"}
{"concept_id": "C2610234", "aliases": [], "types": ["T045"], "canonical_name": "tRNA wobble base lysidine biosynthesis", "definition": "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine. [PMID:15894617]"}
{"concept_id": "C2610235", "aliases": [], "types": ["T044"], "canonical_name": "heparan sulfate lyase activity"}
{"concept_id": "C2610237", "aliases": ["determination of dorsoventral asymmetry", "determination of dorsal-ventral asymmetry", "determination of adaxial/abaxial asymmetry"], "types": ["T040"], "canonical_name": "determination of dorsal/ventral asymmetry", "definition": "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis. [GOC:jid]"}
{"concept_id": "C2610238", "aliases": ["hemopoietic or lymphoid organ development", "haematopoietic or lymphoid organ development", "haemopoietic or lymphoid organ development"], "types": ["T042"], "canonical_name": "hematopoietic or lymphoid organ development", "definition": "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. [GOC:add, GOC:rl, ISBN:0781735149]"}
{"concept_id": "C2610240", "aliases": ["formation of an anatomical structure involved in morphogenesis"], "types": ["T042"], "canonical_name": "anatomical structure formation involved in morphogenesis", "definition": "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C2610241", "aliases": ["neuron morphogenesis involved in differentiation"], "types": ["T043"], "canonical_name": "cell morphogenesis involved in neuron differentiation", "definition": "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610243", "aliases": [], "types": ["T043"], "canonical_name": "lateral line nerve glial cell morphogenesis involved in differentiation", "definition": "The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve. [GOC:dgh]"}
{"concept_id": "C2610244", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line nerve glial cell morphogenesis involved in differentiation", "definition": "The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve. [GOC:dgh]"}
{"concept_id": "C2610245", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line nerve glial cell morphogenesis involved in differentiation", "definition": "The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve. [GOC:dgh]"}
{"concept_id": "C2610247", "aliases": [], "types": ["T044"], "canonical_name": "proteasomal proteolysis associated with antigen processing and presentation", "definition": "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation. [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]"}
{"concept_id": "C2610249", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-5-hydroxy-L-lysine trimethylation", "definition": "The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine. [RESID:AA0359]"}
{"concept_id": "C2610250", "aliases": ["actin bundling activity", "actin cable assembly", "actin cable formation"], "types": ["T043"], "canonical_name": "actin filament bundle assembly", "definition": "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. [GOC:ai]"}
{"concept_id": "C2610253", "aliases": ["maintenance of localization"], "types": ["T038"], "canonical_name": "maintenance of location", "definition": "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2610254", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cGMP phosphodiesterase activity"}
{"concept_id": "C2610255", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cGMP phosphodiesterase activity"}
{"concept_id": "C2610256", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cGMP phosphodiesterase activity"}
{"concept_id": "C2610257", "aliases": [], "types": ["T044"], "canonical_name": "MAPK11 cascade"}
{"concept_id": "C2610258", "aliases": [], "types": ["T044"], "canonical_name": "MAPK12 cascade"}
{"concept_id": "C2610259", "aliases": [], "types": ["T044"], "canonical_name": "MAPK13 cascade"}
{"concept_id": "C2610260", "aliases": [], "types": ["T044"], "canonical_name": "MAPK14 cascade"}
{"concept_id": "C2610261", "aliases": ["p38 MAPK cascade", "p38 cascade"], "types": ["T044"], "canonical_name": "p38MAPK cascade", "definition": "An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. [GOC:signaling, PMID:20811974]"}
{"concept_id": "C2610262", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adrenocorticotropin secretion"}
{"concept_id": "C2610263", "aliases": ["stimulation of adrenocorticotropin secretion"], "types": ["T043"], "canonical_name": "activation of adrenocorticotropin secretion"}
{"concept_id": "C2610297", "aliases": ["establishment of localisation in cell"], "types": ["T043"], "canonical_name": "establishment of localization in cell", "definition": "Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]"}
{"concept_id": "C2610298", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of location in cell", "definition": "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. [GOC:ai]"}
{"concept_id": "C2610299", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of localization in cell"}
{"concept_id": "C2610300", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of chromosome location", "definition": "Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2610302", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of vesicle location", "definition": "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2610303", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of organelle location", "definition": "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2610304", "aliases": ["maintenance of cell nucleus location"], "types": ["T038"], "canonical_name": "maintenance of nucleus location", "definition": "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2610305", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of centrosome location", "definition": "Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2610306", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of spindle location", "definition": "Any process in which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2610307", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of plastid location", "definition": "Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2610308", "aliases": [], "types": ["T040"], "canonical_name": "modification by host of symbiont morphology or physiology"}
{"concept_id": "C2610309", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of pigment granule location", "definition": "Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C2610316", "aliases": ["regulation of host catalytic activity by symbiont", "modulation of catalytic activity of host by symbiont", "regulation by symbiont of host catalytic activity", "modulation by symbiont of host enzyme activity", "regulation of catalytic activity of host by symbiont"], "types": ["T040"], "canonical_name": "modulation by symbiont of host catalytic activity", "definition": "The process in which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06, GOC:tb]"}
{"concept_id": "C2610321", "aliases": [], "types": ["T043"], "canonical_name": "induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C2610323", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C2610324", "aliases": [], "types": ["T040"], "canonical_name": "activation by organism of non-apoptotic programmed cell death in other organism"}
{"concept_id": "C2610325", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction"}
{"concept_id": "C2610326", "aliases": [], "types": ["T040"], "canonical_name": "induction of non-apoptotic programmed cell death by other organism"}
{"concept_id": "C2610327", "aliases": ["modulation by host of symbiont enzyme activity"], "types": ["T040"], "canonical_name": "modulation by host of symbiont catalytic activity", "definition": "The process in which a host organism effects a change in the enzyme activity of its symbiont organism. [GOC:mtg_pamgo_17jul06, GOC:tb]"}
{"concept_id": "C2610334", "aliases": [], "types": ["T042"], "canonical_name": "regulation of cardiac muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle contraction. [GOC:ecd]"}
{"concept_id": "C2610335", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cardiac muscle contraction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. [GOC:ecd]"}
{"concept_id": "C2610336", "aliases": [], "types": ["T040"], "canonical_name": "relaxation of cardiac muscle", "definition": "The process in which the extent of cardiac muscle contraction is reduced. [GOC:ecd]"}
{"concept_id": "C2610337", "aliases": [], "types": ["T026"], "canonical_name": "striated muscle dense body", "definition": "A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere. [GOC:kmv, PMID:17492481]"}
{"concept_id": "C2610338", "aliases": [], "types": ["T043"], "canonical_name": "response to high fluence blue light stimulus by blue high-fluence system", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2. [GOC:mtg_far_red]"}
{"concept_id": "C2610339", "aliases": [], "types": ["T043"], "canonical_name": "response to high fluence blue light"}
{"concept_id": "C2610340", "aliases": [], "types": ["T043"], "canonical_name": "response to high fluence blue light by bhf system"}
{"concept_id": "C2610341", "aliases": [], "types": ["T040"], "canonical_name": "response to very low light intensity stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec. [GOC:mtg_far_red]"}
{"concept_id": "C2610342", "aliases": [], "types": ["T038"], "canonical_name": "digestive system development", "definition": "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:jid]"}
{"concept_id": "C2610344", "aliases": [], "types": ["T042"], "canonical_name": "retinal development"}
{"concept_id": "C2610345", "aliases": [], "types": ["T042"], "canonical_name": "urinary bladder smooth muscle contraction involved in micturition"}
{"concept_id": "C2610346", "aliases": ["syncytium formation induced by viral infection"], "types": ["T043"], "canonical_name": "positive regulation of syncytium formation by virus", "definition": "The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:dph]"}
{"concept_id": "C2610347", "aliases": [], "types": ["T043"], "canonical_name": "astral microtubule depolymerization", "definition": "The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. [GOC:dph]"}
{"concept_id": "C2610348", "aliases": [], "types": ["T044"], "canonical_name": "regulation of nuclear-transcribed mRNA poly(A) tail shortening", "definition": "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610349", "aliases": [], "types": ["T044"], "canonical_name": "regulation of nuclear mRNA poly(A) tail shortening"}
{"concept_id": "C2610350", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of nuclear-transcribed mRNA poly(A) tail shortening", "definition": "Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610351", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of nuclear mRNA poly(A) tail shortening"}
{"concept_id": "C2610352", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "definition": "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610353", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of nuclear mRNA poly(A) tail shortening"}
{"concept_id": "C2610355", "aliases": [], "types": ["T043"], "canonical_name": "oenocyte delamination", "definition": "The negative regulation of cell adhesion process in which an oenocyte splits off of an existing epithelial sheet. [GOC:dph]"}
{"concept_id": "C2610356", "aliases": [], "types": ["T043"], "canonical_name": "neuroblast delamination", "definition": "The negative regulation of cell adhesion process in which a neuroblast splits off of a neurectodermal sheet. [GOC:dph]"}
{"concept_id": "C2610357", "aliases": [], "types": ["T043"], "canonical_name": "lens induction in camera-type eye", "definition": "Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens. [GOC:dph, ISBN:0878932437]"}
{"concept_id": "C2610358", "aliases": ["regulation of mitotic spindle organization and biogenesis", "regulation of mitotic spindle organisation"], "types": ["T043"], "canonical_name": "regulation of mitotic spindle organization", "definition": "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2610359", "aliases": ["regulation of fungal-type cell wall organisation"], "types": ["T043"], "canonical_name": "regulation of fungal-type cell wall organization", "definition": "Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610360", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fungal-type cell wall organization and biogenesis"}
{"concept_id": "C2610364", "aliases": [], "types": ["T044"], "canonical_name": "lysozyme inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of lysozyme. [GOC:dph]"}
{"concept_id": "C2610365", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell growth involved in contact inhibition", "definition": "The negative regulation of cell growth in response to increased cell density. [GOC:dph]"}
{"concept_id": "C2610366", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell proliferation involved in contact inhibition", "definition": "Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density. [GOC:dph]"}
{"concept_id": "C2610367", "aliases": [], "types": ["T043"], "canonical_name": "detection of cell density", "definition": "The series of events in which information about the density of cells in a population is received and converted into a molecular signal. [GOC:dph]"}
{"concept_id": "C2610368", "aliases": [], "types": ["T043"], "canonical_name": "detection of cell density by contact stimulus"}
{"concept_id": "C2610369", "aliases": [], "types": ["T043"], "canonical_name": "detection of cell density by secreted molecule"}
{"concept_id": "C2610370", "aliases": [], "types": ["T043"], "canonical_name": "detection of cell density by contact stimulus involved in contact inhibition"}
{"concept_id": "C2610371", "aliases": ["anatomical structure maintenance"], "types": ["T038"], "canonical_name": "anatomical structure homeostasis", "definition": "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GOC:dph]"}
{"concept_id": "C2610372", "aliases": ["maintenance of germ line stem-cell niche", "germ-line stem-cell niche maintenance", "maintenance of germ-line stem cell niche", "maintenance of germ-line stem-cell niche", "maintenance of germ line stem cell niche"], "types": ["T038"], "canonical_name": "germ-line stem-cell niche homeostasis", "definition": "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion. [GOC:dph]"}
{"concept_id": "C2610373", "aliases": [], "types": ["T038"], "canonical_name": "regulation of glial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of glial cell proliferation. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610374", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glial cell proliferation", "definition": "Any process that activates or increases the rate or extent of glial cell proliferation. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2610375", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glial cell proliferation", "definition": "Any process that stops or decreases the rate or extent of glial cell proliferation. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2610376", "aliases": [], "types": ["T040"], "canonical_name": "regulation of N-terminal protein palmitoylation", "definition": "Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610377", "aliases": [], "types": ["T040"], "canonical_name": "regulation of macromolecule metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610378", "aliases": [], "types": ["T038"], "canonical_name": "regulation of flocculation", "definition": "Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms. [PMID:10591965, PMID:15466424, PMID:16568252]"}
{"concept_id": "C2610379", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of flocculation", "definition": "Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610380", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of filamentous growth", "definition": "Any process that decreases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610381", "aliases": ["regulation of feeding behaviour"], "types": ["T055"], "canonical_name": "regulation of feeding behavior", "definition": "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610382", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription initiation from RNA polymerase II promoter", "definition": "Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2610383", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription initiation from RNA polymerase II promoter", "definition": "Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2610384", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of N-terminal protein palmitoylation", "definition": "Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610385", "aliases": [], "types": ["T040"], "canonical_name": "regulation of respiratory burst", "definition": "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610389", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of respiratory burst", "definition": "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610390", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of respiratory burst", "definition": "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610391", "aliases": [], "types": ["T043"], "canonical_name": "centripetally migrating follicle cell migration", "definition": "The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte. [GOC:dph]"}
{"concept_id": "C2610392", "aliases": [], "types": ["T043"], "canonical_name": "main body follicle cell migration", "definition": "The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte. [GOC:dph]"}
{"concept_id": "C2610393", "aliases": [], "types": ["T040"], "canonical_name": "cilium morphogenesis"}
{"concept_id": "C2610394", "aliases": ["cilium organization", "microtubule-based flagellum organization"], "types": ["T043"], "canonical_name": "cilium organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. [GOC:cilia, GOC:jl]"}
{"concept_id": "C2610395", "aliases": [], "types": ["T040"], "canonical_name": "embryonic skeletal joint morphogenesis", "definition": "The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton. [GOC:bf, GOC:BHF, GOC:dph, UBERON:0000982]"}
{"concept_id": "C2610396", "aliases": [], "types": ["T055"], "canonical_name": "crying behavior", "definition": "The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli. [GOC:dph]"}
{"concept_id": "C2610397", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of stationary phase", "definition": "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrients or a build-up of toxic substances in the environment. [GOC:dph]"}
{"concept_id": "C2610398", "aliases": [], "types": ["T040"], "canonical_name": "maintenance of stationary phase in response to starvation", "definition": "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment. [GOC:dph]"}
{"concept_id": "C2610399", "aliases": [], "types": ["T046"], "canonical_name": "maintenance of stationary phase in response to toxin", "definition": "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment. [GOC:dph]"}
{"concept_id": "C2610402", "aliases": [], "types": ["T038"], "canonical_name": "regulation of ovulation", "definition": "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2610403", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of ovulation", "definition": "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2610404", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of ovulation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2610405", "aliases": [], "types": ["T043"], "canonical_name": "regulation of oocyte development", "definition": "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. [GOC:dph, GOC:tb, PMID:2394318]"}
{"concept_id": "C2610406", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of oocyte development", "definition": "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610407", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of oocyte development", "definition": "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610408", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell development", "definition": "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610409", "aliases": ["ciliary cell motility", "microtubule-based flagellar cell motility", "cilium cell motility"], "types": ["T043"], "canonical_name": "cilium-dependent cell motility", "definition": "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]"}
{"concept_id": "C2610411", "aliases": ["cilium movement involved in determinationof L/R asymmetry"], "types": ["T043"], "canonical_name": "epithelial cilium movement involved in determination of left/right asymmetry", "definition": "The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves. [GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, PMID:28559696, PMID:29367579]"}
{"concept_id": "C2610412", "aliases": ["compartment boundary formation"], "types": ["T040"], "canonical_name": "formation of a compartment boundary", "definition": "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier. [GOC:dph]"}
{"concept_id": "C2610413", "aliases": [], "types": ["T040"], "canonical_name": "compartment boundary maintenance", "definition": "A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier. [GOC:dph]"}
{"concept_id": "C2610414", "aliases": [], "types": ["T043"], "canonical_name": "transdifferentiation", "definition": "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate. [GOC:dph, GOC:kmv]"}
{"concept_id": "C2610415", "aliases": [], "types": ["T042"], "canonical_name": "long term depression"}
{"concept_id": "C2610418", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cilium beat frequency involved in ciliary motility", "definition": "Any process that modulates the frequency of cilium beating involved in ciliary motility. [GOC:BHF, GOC:cilia, GOC:dph, GOC:krc, GOC:tb]"}
{"concept_id": "C2610419", "aliases": ["regulation of sarcomere organisation"], "types": ["T043"], "canonical_name": "regulation of sarcomere organization", "definition": "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610420", "aliases": ["positive regulation of sarcomere organisation"], "types": ["T043"], "canonical_name": "positive regulation of sarcomere organization", "definition": "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610421", "aliases": ["negative regulation of sarcomere organisation"], "types": ["T043"], "canonical_name": "negative regulation of sarcomere organization", "definition": "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610422", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cytokine activity", "definition": "Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610423", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cytokine activity", "definition": "Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610424", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cytokine activity", "definition": "Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610427", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell diameter", "definition": "Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610428", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell width"}
{"concept_id": "C2610429", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane repolarization", "definition": "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]"}
{"concept_id": "C2610430", "aliases": ["regulation of ventricular cardiac muscle cell repolarization", "regulation of ventricular cardiomyocyte membrane repolarization"], "types": ["T042"], "canonical_name": "regulation of ventricular cardiac muscle cell membrane repolarization", "definition": "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]"}
{"concept_id": "C2610431", "aliases": ["regulation of ventricular cardiac muscle repolarization"], "types": ["T042"], "canonical_name": "regulation of ventricular cardiac muscle repolarization"}
{"concept_id": "C2610432", "aliases": [], "types": ["T044"], "canonical_name": "GTP cyclohydrolase I regulator activity", "definition": "Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610433", "aliases": ["elastin catabolism", "elastin breakdown", "elastin degradation"], "types": ["T044"], "canonical_name": "elastin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610434", "aliases": ["regulation of elastin degradation", "regulation of elastin catabolism"], "types": ["T044"], "canonical_name": "regulation of elastin catabolic process", "definition": "Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610435", "aliases": [], "types": ["T044"], "canonical_name": "regulation of elastin breakdown"}
{"concept_id": "C2610436", "aliases": ["negative regulation of elastin catabolism", "negative regulation of elastin degradation", "negative regulation of elastin breakdown", "down-regulation of elastin catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of elastin catabolic process", "definition": "Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610437", "aliases": [], "types": ["T038"], "canonical_name": "regulation of blood vessel remodeling", "definition": "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610438", "aliases": ["down-regulation of blood vessel remodeling"], "types": ["T039"], "canonical_name": "negative regulation of blood vessel remodeling", "definition": "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610439", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of blood vessel remodeling"}
{"concept_id": "C2610440", "aliases": [], "types": ["T038"], "canonical_name": "regulation of ryanodine-sensitive calcium-release channel activity", "definition": "Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610441", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of ryanodine-sensitive calcium-release channel activity", "definition": "Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610442", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of ryanodine-sensitive calcium-release channel activity", "definition": "Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610443", "aliases": ["heart epithelial to mesenchymal transition"], "types": ["T043"], "canonical_name": "cardiac epithelial to mesenchymal transition", "definition": "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, PMID:16314491, PMID:1996351]"}
{"concept_id": "C2610444", "aliases": ["definitive RBC differentiation", "definitive red blood cell differentiation", "definitive erythropoiesis"], "types": ["T043"], "canonical_name": "definitive erythrocyte differentiation", "definition": "Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis. [GOC:add, GOC:BHF, GOC:dph]"}
{"concept_id": "C2610445", "aliases": ["primitive erythropoiesis", "primitive red blood cell differentiation", "primitive RBC differentiation"], "types": ["T043"], "canonical_name": "primitive erythrocyte differentiation", "definition": "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis. [GOC:add, GOC:BHF, GOC:dph]"}
{"concept_id": "C2610446", "aliases": [], "types": ["T043"], "canonical_name": "rejection of self pollen", "definition": "The recognition and rejection of self pollen by cells in the stigma, mediated by the sharing and interaction of the single locus incompatibility haplotypes. [GOC:dph, GOC:tb, PMID:34848142]"}
{"concept_id": "C2610447", "aliases": [], "types": ["T043"], "canonical_name": "acceptance of pollen", "definition": "The recognition and acceptance of pollen by cells in the stigma, mediated by the sharing and interaction of the single locus incompatibility haplotypes. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610448", "aliases": [], "types": ["T043"], "canonical_name": "acceptance of non-self pollen"}
{"concept_id": "C2610449", "aliases": [], "types": ["T043"], "canonical_name": "acceptance of self pollen"}
{"concept_id": "C2610450", "aliases": [], "types": ["T042"], "canonical_name": "head development", "definition": "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. [GOC:dph]"}
{"concept_id": "C2610451", "aliases": [], "types": ["T040"], "canonical_name": "head morphogenesis", "definition": "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. [GOC:dph]"}
{"concept_id": "C2610452", "aliases": [], "types": ["T042"], "canonical_name": "face development", "definition": "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. [GOC:dph]"}
{"concept_id": "C2610453", "aliases": [], "types": ["T040"], "canonical_name": "face morphogenesis", "definition": "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. [GOC:dph]"}
{"concept_id": "C2610454", "aliases": [], "types": ["T043"], "canonical_name": "cell chemotaxis", "definition": "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]"}
{"concept_id": "C2610455", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic actin-based contraction involved in cell motility", "definition": "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another. [GOC:dph]"}
{"concept_id": "C2610456", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic actin-based contraction involved in forward cell motility", "definition": "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell. [GOC:dph]"}
{"concept_id": "C2610457", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic actin-based contraction involved in forward cell locomotion"}
{"concept_id": "C2610458", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic actin-based contraction involved in rearward cell motility", "definition": "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell. [GOC:dph]"}
{"concept_id": "C2610459", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic actin-based contraction involved in rearward cell locomotion"}
{"concept_id": "C2610460", "aliases": ["regulation of response to gamma-interferon", "regulation of response to immune interferon", "regulation of response to type II IFN", "regulation of response to type II interferon"], "types": ["T040"], "canonical_name": "regulation of response to interferon-gamma", "definition": "Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. [GOC:dph]"}
{"concept_id": "C2610462", "aliases": ["negative regulation of response to type II IFN", "negative regulation of response to immune interferon", "negative regulation of response to type II interferon", "negative regulation of response to gamma-interferon"], "types": ["T038"], "canonical_name": "negative regulation of response to interferon-gamma", "definition": "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. [GOC:dph]"}
{"concept_id": "C2610464", "aliases": ["positive regulation of response to type II IFN", "positive regulation of response to immune interferon", "positive regulation of response to type II interferon", "positive regulation of response to gamma-interferon"], "types": ["T038"], "canonical_name": "positive regulation of response to interferon-gamma", "definition": "Any process that increases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. [GOC:dph]"}
{"concept_id": "C2610466", "aliases": ["immune interferon signaling pathway", "gamma-interferon-mediated signaling pathway", "type II interferon-mediated signaling pathway", "interferon-gamma-mediated signalling pathway"], "types": ["T043"], "canonical_name": "interferon-gamma-mediated signaling pathway", "definition": "The series of molecular signals initiated by interferon-gamma binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. [GOC:add, GOC:dph, GOC:signaling]"}
{"concept_id": "C2610467", "aliases": [], "types": ["T043"], "canonical_name": "type II IFN-mediated signaling pathway"}
{"concept_id": "C2610468", "aliases": ["regulation of gamma-interferon-mediated signaling pathway", "regulation of type II IFN-mediated signaling pathway", "regulation of immune interferon signaling pathway", "regulation of interferon-gamma-mediated signalling pathway", "regulation of type II interferon-mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of interferon-gamma-mediated signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph]"}
{"concept_id": "C2610470", "aliases": ["positive regulation of gamma-interferon-mediated signaling pathway", "positive regulation of type II interferon-mediated signaling pathway", "positive regulation of type II IFN-mediated pathway", "positive regulation of immune interferon-mediated signaling pathway", "positive regulation of interferon-gamma-mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of interferon-gamma-mediated signaling pathway", "definition": "Any process that increases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph]"}
{"concept_id": "C2610472", "aliases": ["negative regulation of type II interferon-mediated signaling pathway", "negative regulation of type II IFN-mediated signaling pathway", "negative regulation of gamma-interferon-mediated signaling pathway", "negative regulation of interferon-gamma-mediated signalling pathway", "negative regulation of immune interferon-mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of interferon-gamma-mediated signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph]"}
{"concept_id": "C2610474", "aliases": ["type I interferon-mediated signalling pathway", "type I interferon-activated signaling pathway", "type I interferon-mediated signaling pathway"], "types": ["T043"], "canonical_name": "type I interferon signaling pathway", "definition": "The series of molecular signals initiated by type I interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:dph, GOC:signaling]"}
{"concept_id": "C2610475", "aliases": ["regulation of type I interferon-mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of type I interferon-mediated signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]"}
{"concept_id": "C2610476", "aliases": ["negative regulation of type I interferon-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of type I interferon-mediated signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]"}
{"concept_id": "C2610477", "aliases": ["positive regulation of type I interferon-mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of type I interferon-mediated signaling pathway", "definition": "Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]"}
{"concept_id": "C2610478", "aliases": ["regulation of cellular localisation"], "types": ["T039"], "canonical_name": "regulation of cellular localization", "definition": "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610479", "aliases": [], "types": ["T026"], "canonical_name": "photoreceptor inner segment membrane", "definition": "The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. [GOC:dph]"}
{"concept_id": "C2610480", "aliases": ["trabeculation"], "types": ["T042"], "canonical_name": "trabecula formation", "definition": "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. [GOC:dph]"}
{"concept_id": "C2610481", "aliases": [], "types": ["T042"], "canonical_name": "trabecula biogenesis"}
{"concept_id": "C2610482", "aliases": ["liver trabeculation"], "types": ["T042"], "canonical_name": "liver trabecula formation", "definition": "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:dph]"}
{"concept_id": "C2610483", "aliases": [], "types": ["T042"], "canonical_name": "liver trabecula biogenesis"}
{"concept_id": "C2610484", "aliases": ["spleen trabeculation"], "types": ["T042"], "canonical_name": "spleen trabecula formation", "definition": "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:dph]"}
{"concept_id": "C2610485", "aliases": [], "types": ["T042"], "canonical_name": "spleen trabecula biogenesis"}
{"concept_id": "C2610486", "aliases": ["skeletal trabeculation", "skeletal trabecula formation", "bone trabeculation"], "types": ["T042"], "canonical_name": "bone trabecula formation", "definition": "The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:dph]"}
{"concept_id": "C2610487", "aliases": [], "types": ["T042"], "canonical_name": "bone trabecula biogenesis"}
{"concept_id": "C2610488", "aliases": [], "types": ["T042"], "canonical_name": "skeletal trabecula biogenesis"}
{"concept_id": "C2610489", "aliases": ["heart trabeculation", "cardiac trabecula formation", "cardiac trabeculation"], "types": ["T042"], "canonical_name": "heart trabecula formation", "definition": "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:dph]"}
{"concept_id": "C2610490", "aliases": [], "types": ["T042"], "canonical_name": "heart trabecula biogenesis"}
{"concept_id": "C2610491", "aliases": [], "types": ["T040"], "canonical_name": "bone morphogenesis", "definition": "The process in which bones are generated and organized. [GOC:dph]"}
{"concept_id": "C2610492", "aliases": [], "types": ["T040"], "canonical_name": "endochondral bone morphogenesis", "definition": "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. [GOC:dph, PMID:11680679]"}
{"concept_id": "C2610493", "aliases": [], "types": ["T042"], "canonical_name": "cartilage development involved in endochondral bone morphogenesis", "definition": "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. [GOC:dph]"}
{"concept_id": "C2610494", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion molecule production", "definition": "The appearance of a cell adhesion molecule due to biosynthesis or secretion. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2610495", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell adhesion molecule production", "definition": "Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2610496", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell adhesion molecule production", "definition": "Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2610497", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell adhesion molecule production", "definition": "Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2610501", "aliases": ["regulation of leucine uptake"], "types": ["T044"], "canonical_name": "regulation of leucine import", "definition": "Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610502", "aliases": [], "types": ["T044"], "canonical_name": "regulation of L-leucine import"}
{"concept_id": "C2610503", "aliases": [], "types": ["T044"], "canonical_name": "regulation of L-leucine uptake"}
{"concept_id": "C2610504", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of leucine import", "definition": "Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610505", "aliases": ["response to ammonia"], "types": ["T043"], "canonical_name": "response to ammonium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23509267]"}
{"concept_id": "C2610506", "aliases": ["negative regulation of leucine uptake in response to ammonium ion"], "types": ["T044"], "canonical_name": "negative regulation of leucine import in response to ammonium ion", "definition": "Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610507", "aliases": [], "types": ["T067"], "definition": "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement. [GOC:dph]", "canonical_name": "flight"}
{"concept_id": "C2610508", "aliases": [], "types": ["T040"], "canonical_name": "flight involved in flight behavior", "definition": "Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight. [GOC:dph]"}
{"concept_id": "C2610509", "aliases": [], "types": ["T040"], "canonical_name": "cranial suture morphogenesis", "definition": "The process in which any suture between cranial bones is generated and organized. [GOC:dph, GOC:pr, GOC:sl]"}
{"concept_id": "C2610510", "aliases": ["interfrontal suture morphogenesis"], "types": ["T042"], "canonical_name": "frontal suture morphogenesis", "definition": "The process in which the frontal suture is generated and organized. [GOC:dph, GOC:sl]"}
{"concept_id": "C2610511", "aliases": [], "types": ["T040"], "canonical_name": "coronal suture morphogenesis", "definition": "The process in which the coronal suture is generated and organized. [GOC:dph, GOC:sl]"}
{"concept_id": "C2610512", "aliases": [], "types": ["T040"], "canonical_name": "lambdoid suture morphogenesis", "definition": "The process in which the lambdoid suture is generated and organized. [GOC:dph, GOC:sl]"}
{"concept_id": "C2610514", "aliases": ["regulation of Fc receptor mediated stimulatory signalling pathway"], "types": ["T038"], "canonical_name": "regulation of Fc receptor mediated stimulatory signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway.. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610515", "aliases": ["positive regulation of Fc receptor mediated stimulatory signalling pathway"], "types": ["T038"], "canonical_name": "positive regulation of Fc receptor mediated stimulatory signaling pathway", "definition": "Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610516", "aliases": [], "types": ["T043"], "canonical_name": "susceptibility to T cell mediated cytotoxicity", "definition": "The process of causing a cell to become susceptible to T cell mediated cytotoxicity. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610517", "aliases": ["regulation of atrial cardiac muscle cell depolarization", "regulation of atrial cardiomyocyte membrane depolarization"], "types": ["T039"], "canonical_name": "regulation of atrial cardiac muscle cell membrane depolarization", "definition": "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610518", "aliases": ["regulation of atrial cardiac muscle cell repolarization", "regulation of atrial cardiomyocyte membrane repolarization"], "types": ["T042"], "canonical_name": "regulation of atrial cardiac muscle cell membrane repolarization", "definition": "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610520", "aliases": ["regulation of ventricular cardiomyocyte membrane depolarization"], "types": ["T039"], "canonical_name": "regulation of ventricular cardiac muscle cell membrane depolarization", "definition": "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610521", "aliases": [], "types": ["T043"], "canonical_name": "mast cell differentiation", "definition": "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610522", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mast cell differentiation", "definition": "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610523", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mast cell differentiation", "definition": "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610524", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mast cell differentiation", "definition": "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610525", "aliases": [], "types": ["T039"], "canonical_name": "regulation of brood size", "definition": "Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610526", "aliases": ["cardiac myoblast differentiation", "myocardial precursor cell differentiation"], "types": ["T043"], "canonical_name": "cardiac muscle cell myoblast differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610528", "aliases": ["regulation of telomeric ssDNA binding"], "types": ["T045"], "canonical_name": "regulation of single-stranded telomeric DNA binding", "definition": "Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610529", "aliases": ["positive regulation of telomeric ssDNA binding"], "types": ["T044"], "canonical_name": "positive regulation of single-stranded telomeric DNA binding", "definition": "Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610530", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA strand elongation", "definition": "Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. [GOC:mah]"}
{"concept_id": "C2610531", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of DNA strand elongation", "definition": "Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. [GOC:mah]"}
{"concept_id": "C2610532", "aliases": [], "types": ["T042"], "canonical_name": "axonogenesis involved in innervation", "definition": "The neurite development process that generates a long process of a neuron, as it invades a target tissue. [GOC:dph, GOC:sart]"}
{"concept_id": "C2610533", "aliases": ["synapse biogenesis involved in innervation", "synaptogenesis involved in innervation"], "types": ["T042"], "canonical_name": "synapse assembly involved in innervation", "definition": "The assembly of a synapse within a target tissue in which a nerve is invading. [GOC:dph, GOC:pr, GOC:sart]"}
{"concept_id": "C2610534", "aliases": [], "types": ["T026"], "canonical_name": "fertilization envelope", "definition": "A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release. [GOC:dph, ISBN:0878932437]"}
{"concept_id": "C2610535", "aliases": ["fertilization membrane"], "types": ["T026"], "canonical_name": "fertilization membrane"}
{"concept_id": "C2610536", "aliases": [], "types": ["T026"], "canonical_name": "vitelline envelope", "definition": "A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization. [GOC:dph, ISBN:0878932437]"}
{"concept_id": "C2610537", "aliases": ["receptor-regulated SMAD protein phosphorylation", "receptor regulated SMAD protein phosphorylation", "R-SMAD protein phosphorylation", "pathway restricted SMAD protein phosphorylation"], "types": ["T044"], "canonical_name": "pathway-restricted SMAD protein phosphorylation", "definition": "The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. [GOC:dph, ISBN:3527303782]"}
{"concept_id": "C2610538", "aliases": [], "types": ["T044"], "canonical_name": "regulation of SMAD protein nuclear translocation"}
{"concept_id": "C2610539", "aliases": ["positive regulation of SMAD protein nuclear translocation"], "types": ["T043"], "canonical_name": "positive regulation of SMAD protein import into nucleus"}
{"concept_id": "C2610540", "aliases": ["negative regulation of SMAD protein nuclear translocation"], "types": ["T043"], "canonical_name": "negative regulation of SMAD protein import into nucleus"}
{"concept_id": "C2610541", "aliases": [], "types": ["T044"], "canonical_name": "regulation of pathway-restricted SMAD protein phosphorylation", "definition": "Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610542", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of pathway-restricted SMAD protein phosphorylation", "definition": "Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610543", "aliases": [], "types": ["T043"], "canonical_name": "SMAD protein signal transduction", "definition": "The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610544", "aliases": ["growth hormone receptor signalling pathway", "GH receptor signaling pathway"], "types": ["T044"], "canonical_name": "growth hormone receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. [GOC:BHF, GOC:dph, PMID:11445442]"}
{"concept_id": "C2610545", "aliases": [], "types": ["T044"], "canonical_name": "cellular response to growth hormone"}
{"concept_id": "C2610546", "aliases": ["JAK-STAT cascade involved in growth hormone signalling pathway"], "types": ["T044"], "canonical_name": "growth hormone receptor signaling pathway via JAK-STAT", "definition": "The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. [GOC:BHF, GOC:dph, PMID:11445442]"}
{"concept_id": "C2610547", "aliases": ["regulation of growth hormone receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of growth hormone receptor signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. [GOC:BHF, GOC:dph]"}
{"concept_id": "C2610548", "aliases": ["positive regulation of growth hormone receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of growth hormone receptor signaling pathway", "definition": "Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. [GOC:BHF, GOC:dph]"}
{"concept_id": "C2610549", "aliases": ["negative regulation of growth hormone receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of growth hormone receptor signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. [GOC:dph]"}
{"concept_id": "C2610551", "aliases": [], "types": ["T044"], "canonical_name": "calcium ion transport into cytosol", "definition": "The directed movement of calcium ions (Ca2+) into the cytosol. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610552", "aliases": [], "types": ["T040"], "canonical_name": "post-mating oviposition"}
{"concept_id": "C2610553", "aliases": [], "types": ["T043"], "canonical_name": "axonemal microtubule depolymerization", "definition": "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. [GOC:cilia, GOC:dph, GOC:krc, GOC:tb]"}
{"concept_id": "C2610554", "aliases": [], "types": ["T038"], "canonical_name": "regulation of penile erection", "definition": "Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C2610555", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of penile erection", "definition": "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610556", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of penile erection", "definition": "Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610557", "aliases": [], "types": ["T040"], "canonical_name": "regulation of acetylcholine metabolic process", "definition": "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610558", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of acetylcholine metabolic process", "definition": "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610559", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of acetylcholine metabolic process", "definition": "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610560", "aliases": ["heart septum morphogenesis"], "types": ["T040"], "canonical_name": "cardiac septum morphogenesis", "definition": "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C2610561", "aliases": ["interventricular septum morphogenesis"], "types": ["T040"], "canonical_name": "ventricular septum morphogenesis", "definition": "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. [GOC:dph]"}
{"concept_id": "C2610562", "aliases": ["interatrial septum morphogenesis"], "types": ["T042"], "canonical_name": "atrial septum morphogenesis", "definition": "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C2610563", "aliases": [], "types": ["T042"], "canonical_name": "aorta smooth muscle tissue morphogenesis", "definition": "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta]"}
{"concept_id": "C2610564", "aliases": [], "types": ["T042"], "canonical_name": "muscle tissue morphogenesis", "definition": "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. [GOC:dph]"}
{"concept_id": "C2610565", "aliases": ["response to growth hormone stimulus"], "types": ["T043"], "canonical_name": "response to growth hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. [GOC:BHF, GOC:dph]"}
{"concept_id": "C2610566", "aliases": [], "types": ["T026"], "canonical_name": "yolk", "definition": "The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo. [GOC:dph, GOC:tb, PMID:18046696]"}
{"concept_id": "C2610567", "aliases": [], "types": ["T026"], "canonical_name": "yolk plasma", "definition": "Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed. [GOC:dph, GOC:tb, PMID:18046696]"}
{"concept_id": "C2610568", "aliases": [], "types": ["T040"], "canonical_name": "heart growth", "definition": "The increase in size or mass of the heart. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610569", "aliases": [], "types": ["T040"], "canonical_name": "regulation of heart growth", "definition": "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610570", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of heart growth", "definition": "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2610571", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-dipeptidase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610572", "aliases": [], "types": ["T043"], "canonical_name": "foregut regionalization", "definition": "The pattern specification process that results in the spatial subdivision of an axis or axes along the foregut to define an area or volume in which specific patterns of cell differentiation will take place. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610573", "aliases": ["lung specification"], "types": ["T042"], "canonical_name": "lung field specification", "definition": "The process that results in the delineation of a specific region of the foregut into the area in which the lung will develop. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610574", "aliases": [], "types": ["T042"], "canonical_name": "lung morphogenesis", "definition": "The process in which the anatomical structures of the lung are generated and organized. [GOC:dph]"}
{"concept_id": "C2610575", "aliases": ["pulmonary vasculature development"], "types": ["T042"], "canonical_name": "lung vasculature development", "definition": "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610576", "aliases": ["pulmonary connective tissue development"], "types": ["T042"], "canonical_name": "lung connective tissue development", "definition": "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610577", "aliases": ["pulmonary epithelium development"], "types": ["T042"], "canonical_name": "lung epithelium development", "definition": "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610578", "aliases": [], "types": ["T042"], "canonical_name": "epithelium development", "definition": "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610579", "aliases": [], "types": ["T042"], "canonical_name": "lung saccule development", "definition": "The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610580", "aliases": [], "types": ["T042"], "canonical_name": "lung saccular development"}
{"concept_id": "C2610581", "aliases": ["lung formation"], "types": ["T042"], "canonical_name": "primary lung bud formation", "definition": "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610582", "aliases": [], "types": ["T042"], "canonical_name": "lung pattern specification process", "definition": "Any developmental process that results in the creation of defined areas or spaces within the lung, to which cells respond and eventually are instructed to differentiate. [GOC:dph]"}
{"concept_id": "C2610583", "aliases": [], "types": ["T038"], "canonical_name": "bronchus development", "definition": "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs. [GOC:dph]"}
{"concept_id": "C2610584", "aliases": [], "types": ["T042"], "canonical_name": "bronchus morphogenesis", "definition": "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs. [GOC:dph]"}
{"concept_id": "C2610585", "aliases": [], "types": ["T042"], "canonical_name": "bronchiole development", "definition": "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610586", "aliases": [], "types": ["T040"], "canonical_name": "bronchiole morphogenesis", "definition": "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. [GOC:dph]"}
{"concept_id": "C2610587", "aliases": [], "types": ["T040"], "canonical_name": "lung growth", "definition": "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. [GOC:dph]"}
{"concept_id": "C2610588", "aliases": [], "types": ["T038"], "canonical_name": "trachea development", "definition": "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. [GOC:dph]"}
{"concept_id": "C2610589", "aliases": [], "types": ["T042"], "canonical_name": "trachea morphogenesis", "definition": "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. [GOC:dph]"}
{"concept_id": "C2610590", "aliases": [], "types": ["T042"], "canonical_name": "trachea formation", "definition": "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. [GOC:dph]"}
{"concept_id": "C2610591", "aliases": ["lung branching morphogenesis"], "types": ["T040"], "canonical_name": "epithelial tube branching involved in lung morphogenesis", "definition": "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610592", "aliases": ["prostate gland branching morphogenesis"], "types": ["T040"], "canonical_name": "branching involved in prostate gland morphogenesis", "definition": "The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem. [GOC:dph]"}
{"concept_id": "C2610593", "aliases": [], "types": ["T040"], "canonical_name": "prostate branching"}
{"concept_id": "C2610594", "aliases": [], "types": ["T040"], "canonical_name": "mammary gland morphogenesis", "definition": "The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph]"}
{"concept_id": "C2610595", "aliases": ["mammary gland branching morphogenesis"], "types": ["T040"], "canonical_name": "branching involved in mammary gland duct morphogenesis", "definition": "The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph]"}
{"concept_id": "C2610596", "aliases": [], "types": ["T040"], "canonical_name": "branching involved in salivary gland morphogenesis", "definition": "The process in which the branching structure of the salivary gland is generated and organized. [GOC:dph]"}
{"concept_id": "C2610597", "aliases": [], "types": ["T042"], "canonical_name": "branching involved in open tracheal system development", "definition": "The process in which the anatomical structures of branches in the open tracheal system are generated and organized. [GOC:dph]"}
{"concept_id": "C2610598", "aliases": ["bud formation involved in lung branching"], "types": ["T040"], "canonical_name": "bud outgrowth involved in lung branching", "definition": "The process in which a region of the lung epithelium initiates an outgrowth. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610599", "aliases": ["bud bifurcation involved in lung branching"], "types": ["T042"], "canonical_name": "dichotomous subdivision of terminal units involved in lung branching", "definition": "The process in which a lung bud bifurcates. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610600", "aliases": [], "types": ["T040"], "canonical_name": "bud elongation involved in lung branching", "definition": "The process in which a bud in the lung grows out from the point where it is formed. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610601", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of hindgut contraction", "definition": "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610602", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of hindgut contraction", "definition": "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610603", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of cardiac muscle contraction", "definition": "Any process that increases the frequency, rate or extent of cardiac muscle contraction. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610604", "aliases": [], "types": ["T038"], "canonical_name": "regulation of gastric acid secretion", "definition": "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610605", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of gastric acid secretion", "definition": "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610606", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of gastric acid secretion", "definition": "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610607", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of digestive system process", "definition": "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610608", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of digestive system process", "definition": "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:dph, GOC:tb]"}
{"concept_id": "C2610609", "aliases": ["right pulmonary development"], "types": ["T042"], "canonical_name": "right lung development", "definition": "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610610", "aliases": ["left pulmonary development"], "types": ["T042"], "canonical_name": "left lung development", "definition": "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610611", "aliases": [], "types": ["T042"], "canonical_name": "left lung morphogenesis", "definition": "The process in which anatomical structures of the left lung are generated and organized. [GOC:dph]"}
{"concept_id": "C2610612", "aliases": [], "types": ["T042"], "canonical_name": "right lung morphogenesis", "definition": "The process in which anatomical structures of the right lung are generated and organized. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2610613", "aliases": [], "types": ["T042"], "canonical_name": "lung lobe development", "definition": "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. [GOC:dph]"}
{"concept_id": "C2610614", "aliases": [], "types": ["T040"], "canonical_name": "lung lobe morphogenesis", "definition": "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. [GOC:dph]"}
{"concept_id": "C2610615", "aliases": [], "types": ["T042"], "canonical_name": "lung lobe formation", "definition": "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. [GOC:dph]"}
{"concept_id": "C2610616", "aliases": [], "types": ["T042"], "canonical_name": "pharynx development", "definition": "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. [GOC:dph, GOC:rk]"}
{"concept_id": "C2610617", "aliases": [], "types": ["T042"], "canonical_name": "pharyngeal development"}
{"concept_id": "C2610618", "aliases": [], "types": ["T044"], "canonical_name": "aspartic-type peptidase activity", "definition": "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]"}
{"concept_id": "C2610619", "aliases": [], "types": ["T044"], "canonical_name": "glutamic-type peptidase activity", "definition": "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]"}
{"concept_id": "C2610620", "aliases": [], "types": ["T044"], "canonical_name": "threonine-type peptidase activity", "definition": "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]"}
{"concept_id": "C2610621", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type exopeptidase activity", "definition": "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]"}
{"concept_id": "C2610622", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type aminopeptidase activity", "definition": "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]"}
{"concept_id": "C2610623", "aliases": [], "types": ["T044"], "canonical_name": "metalloaminopeptidase activity", "definition": "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]"}
{"concept_id": "C2610624", "aliases": [], "types": ["T044"], "canonical_name": "glutamic-type endopeptidase activity", "definition": "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]"}
{"concept_id": "C2610625", "aliases": [], "types": ["T044"], "canonical_name": "serine-type exopeptidase activity", "definition": "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]"}
{"concept_id": "C2610626", "aliases": [], "types": ["T044"], "canonical_name": "serine-type aminopeptidase activity", "definition": "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]"}
{"concept_id": "C2610629", "aliases": [], "types": ["T044"], "canonical_name": "oligopeptidase activity", "definition": "Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2610630", "aliases": [], "types": ["T026"], "canonical_name": "intracellular organelle lumen", "definition": "An organelle lumen that is part of an intracellular organelle. [GOC:mah]"}
{"concept_id": "C2610631", "aliases": ["sucrase-isomaltase complex"], "types": ["T026"], "definition": "A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities. [PMID:3366777]", "canonical_name": "sucrase-isomaltase complex location"}
{"concept_id": "C2610632", "aliases": ["oligo-1,6-glucosidase complex location"], "types": ["T026"], "canonical_name": "oligo-1,6-glucosidase complex"}
{"concept_id": "C2610633", "aliases": ["Arm repeat domain binding", "armadillo repeat binding", "armadillo domain binding"], "types": ["T044"], "canonical_name": "armadillo repeat domain binding", "definition": "Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225]"}
{"concept_id": "C2610634", "aliases": ["alphav-beta3 integrin-thrombospondin complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-thrombospondin complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin. [PMID:2478219]"}
{"concept_id": "C2610635", "aliases": ["ITGAV-ITGB3-THBS1 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3-THBS1 complex"}
{"concept_id": "C2610639", "aliases": ["TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex", "TGF-beta1-type II receptor-type I receptor complex location", "TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex location", "transforming growth factor beta1-type II receptor-type I receptor complex location", "TGF-beta 1:type II receptor:type I receptor complex location", "TGF-beta1-type II receptor-type I receptor complex", "TGF-beta 1:type II receptor:type I receptor complex"], "types": ["T026"], "canonical_name": "transforming growth factor beta1-type II receptor-type I receptor complex"}
{"concept_id": "C2610641", "aliases": ["IL12-IL12 receptor complex", "IL12-IL12 receptor complex location", "interleukin-12-interleukin-12 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-12-interleukin-12 receptor complex", "definition": "A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer. [PMID:11900991]"}
{"concept_id": "C2610642", "aliases": ["IL12B-IL12RB1-IL12RB2 complex location"], "types": ["T026"], "canonical_name": "IL12B-IL12RB1-IL12RB2 complex"}
{"concept_id": "C2610643", "aliases": ["CD19-Vav-PI 3-kinase (p85 subunit) complex", "CD19-Vav-PI 3-kinase (p85 subunit) complex location", "CD19-Vav-PIK3R1 complex location"], "types": ["T026"], "canonical_name": "CD19-Vav-PIK3R1 complex", "definition": "A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K). [PMID:7528218]"}
{"concept_id": "C2610644", "aliases": ["CO binding"], "types": ["T044"], "canonical_name": "carbon monoxide binding", "definition": "Binding to carbon monoxide (CO). [GOC:ecd]"}
{"concept_id": "C2610645", "aliases": ["nitrogen monoxide binding", "NO binding", "nitrosyl binding"], "types": ["T044"], "canonical_name": "nitric oxide binding", "definition": "Binding to nitric oxide (NO). [GOC:ecd]"}
{"concept_id": "C2610646", "aliases": ["carbon monoxide sensing activity"], "types": ["T044"], "canonical_name": "carbon monoxide sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO). [GOC:ecd]"}
{"concept_id": "C2610648", "aliases": ["alphav-beta3 integrin-osteopontin complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-osteopontin complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin. [PMID:7532190]"}
{"concept_id": "C2610649", "aliases": ["ITGAV-ITGB3-SPP1 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3-SPP1 complex"}
{"concept_id": "C2610650", "aliases": ["alphav-beta1 integrin-osteopontin complex location"], "types": ["T026"], "canonical_name": "alphav-beta1 integrin-osteopontin complex", "definition": "A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin. [PMID:7592829]"}
{"concept_id": "C2610651", "aliases": ["ITGAV-ITGB1-SPP1 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB1-SPP1 complex"}
{"concept_id": "C2610652", "aliases": ["alphav-beta5 integrin-osteopontin complex location"], "types": ["T026"], "canonical_name": "alphav-beta5 integrin-osteopontin complex", "definition": "A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin. [PMID:7592829]"}
{"concept_id": "C2610653", "aliases": ["ITGAV-ITGB5-SPP1 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB5-SPP1 complex"}
{"concept_id": "C2610654", "aliases": ["synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex location"], "types": ["T026"], "canonical_name": "synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex", "definition": "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof). [PMID:7553862]"}
{"concept_id": "C2610655", "aliases": ["SNARE complex location (Vamp2, Snap25, Stx1a, Cplx1)"], "types": ["T026"], "canonical_name": "SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)"}
{"concept_id": "C2610656", "aliases": ["Vamp2-Snap25-Stx1a-Cplx1 complex location"], "types": ["T026"], "canonical_name": "Vamp2-Snap25-Stx1a-Cplx1 complex"}
{"concept_id": "C2610657", "aliases": ["synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex location"], "types": ["T026"], "canonical_name": "synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex", "definition": "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof). [PMID:7553862]"}
{"concept_id": "C2610658", "aliases": ["SNARE complex location (Vamp2, Snap25, Stx1a, Cplx2)"], "types": ["T026"], "canonical_name": "SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)"}
{"concept_id": "C2610659", "aliases": ["Vamp2-Snap25-Stx1a-Cplx2 complex location"], "types": ["T026"], "canonical_name": "Vamp2-Snap25-Stx1a-Cplx2 complex"}
{"concept_id": "C2610660", "aliases": [], "types": ["T045"], "canonical_name": "telomerase RNA binding", "definition": "Binding to the telomerase RNA template. [GOC:krc, PMID:16884717]"}
{"concept_id": "C2610664", "aliases": [], "types": ["T045"], "canonical_name": "rRNA (pseudouridine) methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule. [GOC:imk, GOC:mah]"}
{"concept_id": "C2610665", "aliases": [], "types": ["T045"], "canonical_name": "rRNA (pseudouridine-N3-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine. [GOC:imk, GOC:mah]"}
{"concept_id": "C2610666", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (guanosine-2'-O-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine. [GOC:imk, GOC:mah]"}
{"concept_id": "C2610667", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (adenine-C2-)-methyltransferase activity", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA. [GOC:imk, PMID:20007606, PMID:20184321, PMID:21368151, PMID:21415317, PMID:21527678]"}
{"concept_id": "C2610668", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (uridine-C5-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine. [GOC:imk, GOC:mah]"}
{"concept_id": "C2610669", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (uridine-N3-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine. [GOC:imk, GOC:mah]"}
{"concept_id": "C2610670", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (guanine-N7-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine. [GOC:imk, GOC:mah]"}
{"concept_id": "C2610671", "aliases": ["Stx1a-SNAP25-VAMP complex", "synaptobrevin 2-SNAP-25-syntaxin-1a complex location", "SNARE complex (Stx1a, SNAP25, VAMP)", "SNARE complex location (Stx1a, SNAP25, VAMP)", "Stx1a-SNAP25-VAMP complex location"], "types": ["T026"], "canonical_name": "synaptobrevin 2-SNAP-25-syntaxin-1a complex", "definition": "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof). [PMID:10336434]"}
{"concept_id": "C2610672", "aliases": ["Snap25-Stx1a-Vamp2 complex location"], "types": ["T026"], "canonical_name": "Snap25-Stx1a-Vamp2 complex"}
{"concept_id": "C2610673", "aliases": ["SNARE complex location (Snap25, Stx1a, Vamp2)"], "types": ["T026"], "canonical_name": "SNARE complex (Snap25, Stx1a, Vamp2)"}
{"concept_id": "C2610674", "aliases": ["synaptobrevin 2-SNAP-25-syntaxin-2 complex location"], "types": ["T026"], "canonical_name": "synaptobrevin 2-SNAP-25-syntaxin-2 complex", "definition": "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof). [PMID:10336434]"}
{"concept_id": "C2610675", "aliases": ["SNARE complex location (Stx2, Snap25, Vamp2)"], "types": ["T026"], "canonical_name": "SNARE complex (Stx2, Snap25, Vamp2)"}
{"concept_id": "C2610676", "aliases": ["Stx2-Snap25-Vamp2 complex location"], "types": ["T026"], "canonical_name": "Stx2-Snap25-Vamp2 complex"}
{"concept_id": "C2610677", "aliases": ["synaptobrevin 2-SNAP-25-syntaxin-3 complex location"], "types": ["T026"], "canonical_name": "synaptobrevin 2-SNAP-25-syntaxin-3 complex", "definition": "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof). [PMID:10336434]"}
{"concept_id": "C2610678", "aliases": ["SNARE complex location (Stx3, Snap25, Vamp2)"], "types": ["T026"], "canonical_name": "SNARE complex (Stx3, Snap25, Vamp2)"}
{"concept_id": "C2610679", "aliases": ["Stx3-Snap25-Vamp2 complex location"], "types": ["T026"], "canonical_name": "Stx3-Snap25-Vamp2 complex"}
{"concept_id": "C2610680", "aliases": ["synaptobrevin 2-SNAP-25-syntaxin-4 complex location"], "types": ["T026"], "canonical_name": "synaptobrevin 2-SNAP-25-syntaxin-4 complex", "definition": "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof). [PMID:10336434]"}
{"concept_id": "C2610681", "aliases": ["SNARE complex location (Stx4, Snap25, Vamp2)"], "types": ["T026"], "canonical_name": "SNARE complex (Stx4, Snap25, Vamp2)"}
{"concept_id": "C2610682", "aliases": ["Stx4-Snap25-Vamp2 complex location"], "types": ["T026"], "canonical_name": "Stx4-Snap25-Vamp2 complex"}
{"concept_id": "C2610683", "aliases": ["endobrevin-SNAP-25-syntaxin-1a complex location"], "types": ["T026"], "canonical_name": "endobrevin-SNAP-25-syntaxin-1a complex", "definition": "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof). [PMID:10336434]"}
{"concept_id": "C2610684", "aliases": ["SNARE complex location (Stx1a, Snap25, Vamp8)"], "types": ["T026"], "canonical_name": "SNARE complex (Stx1a, Snap25, Vamp8)"}
{"concept_id": "C2610685", "aliases": ["Stx1a-Snap25-Vamp8 complex location"], "types": ["T026"], "canonical_name": "Stx1a-Snap25-Vamp8 complex"}
{"concept_id": "C2610686", "aliases": ["endobrevin-SNAP-25-syntaxin-2 complex location"], "types": ["T026"], "canonical_name": "endobrevin-SNAP-25-syntaxin-2 complex", "definition": "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof). [PMID:10336434]"}
{"concept_id": "C2610687", "aliases": ["SNARE complex location (Stx2, Snap25, Vamp8)"], "types": ["T026"], "canonical_name": "SNARE complex (Stx2, Snap25, Vamp8)"}
{"concept_id": "C2610688", "aliases": ["Stx2-Snap25-Vamp8 complex location"], "types": ["T026"], "canonical_name": "Stx2-Snap25-Vamp8 complex"}
{"concept_id": "C2610689", "aliases": ["neuron maintenance"], "types": ["T043"], "canonical_name": "neuron cellular homeostasis", "definition": "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610690", "aliases": [], "types": ["T044"], "canonical_name": "fibrinogen binding", "definition": "Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade. [GOC:BHF, GOC:mah, GOC:vk]"}
{"concept_id": "C2610691", "aliases": [], "types": ["T044"], "canonical_name": "collagen V binding", "definition": "Binding to a type V collagen trimer. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610692", "aliases": [], "types": ["T044"], "canonical_name": "thrombospondin receptor activity", "definition": "Combining with thrombospondin and transmitting the signal to initiate a change in cell activity. [GOC:BHF, GOC:signaling, GOC:vk]"}
{"concept_id": "C2610693", "aliases": ["cytosolic mRNA splicing"], "types": ["T045"], "canonical_name": "mRNA splicing, via endonucleolytic cleavage and ligation", "definition": "Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. [GOC:krc, GOC:mah]"}
{"concept_id": "C2610695", "aliases": ["forespore membrane leading edge"], "types": ["T024"], "canonical_name": "prospore membrane leading edge", "definition": "The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization. [GOC:mah, PMID:14702385]"}
{"concept_id": "C2610696", "aliases": ["forespore membrane spindle pole body attachment site", "prospore membrane SPB attachment site", "forespore membrane SPB attachment site"], "types": ["T024"], "canonical_name": "prospore membrane spindle pole body attachment site", "definition": "The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus. [GOC:mah, PMID:14702385]"}
{"concept_id": "C2610697", "aliases": [], "types": ["T045"], "canonical_name": "tRNA gene clustering", "definition": "The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae. [GOC:jh, GOC:mah, PMID:18708579]"}
{"concept_id": "C2610698", "aliases": ["apoptosis in response to ER stress", "endoplasmic reticulum stress-induced apoptosis", "intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "apoptosis triggered by ER stress", "apoptosis in response to endoplasmic reticulum stress", "ER stress-induced apoptosis"], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]"}
{"concept_id": "C2610699", "aliases": [], "types": ["T044"], "canonical_name": "'de novo' actin filament nucleation", "definition": "The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament. [GOC:mah, PMID:17477841]"}
{"concept_id": "C2610700", "aliases": [], "types": ["T044"], "canonical_name": "formin-mediated actin filament nucleation"}
{"concept_id": "C2610701", "aliases": [], "types": ["T044"], "canonical_name": "unbranched actin filament nucleation"}
{"concept_id": "C2610702", "aliases": [], "types": ["T044"], "canonical_name": "fructose binding", "definition": "Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose. [CHEBI:28757, GOC:BHF, GOC:mah]"}
{"concept_id": "C2610704", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase binding", "definition": "Binding to an RNA polymerase molecule or complex. [GOC:BHF, GOC:mah, GOC:txnOH]"}
{"concept_id": "C2610705", "aliases": [], "types": ["T044"], "canonical_name": "proline-rich region binding", "definition": "Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. [GOC:mah]"}
{"concept_id": "C2610706", "aliases": ["cellubrevin-VAMP4-syntaxin-16 complex location"], "types": ["T026"], "canonical_name": "cellubrevin-VAMP4-syntaxin-16 complex", "definition": "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof). [PMID:11839770]"}
{"concept_id": "C2610707", "aliases": ["SNARE complex location (Vamp3, Vamp4, Stx16)"], "types": ["T026"], "canonical_name": "SNARE complex (Vamp3, Vamp4, Stx16)"}
{"concept_id": "C2610708", "aliases": ["Vamp3-Vamp4-Stx16 complex location"], "types": ["T026"], "canonical_name": "Vamp3-Vamp4-Stx16 complex"}
{"concept_id": "C2610709", "aliases": ["cellubrevin-VAMP4-endobrevin-syntaxin-6 complex location"], "types": ["T026"], "canonical_name": "cellubrevin-VAMP4-endobrevin-syntaxin-6 complex", "definition": "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof). [PMID:11839770]"}
{"concept_id": "C2610710", "aliases": ["SNARE complex location (Vamp3, Vamp4, Vam8, Stx6)"], "types": ["T026"], "canonical_name": "SNARE complex (Vamp3, Vamp4, Vam8, Stx6)"}
{"concept_id": "C2610711", "aliases": ["Vamp3-Vamp4-Vam8-Stx6 complex location"], "types": ["T026"], "canonical_name": "Vamp3-Vamp4-Vam8-Stx6 complex"}
{"concept_id": "C2610712", "aliases": ["syntaxin-6-syntaxin-16-Vti1a complex location"], "types": ["T026"], "canonical_name": "syntaxin-6-syntaxin-16-Vti1a complex", "definition": "A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof). [PMID:11839770]"}
{"concept_id": "C2610713", "aliases": ["VAMP4-syntaxin-6-syntaxin-16-Vti1a complex location"], "types": ["T026"], "canonical_name": "VAMP4-syntaxin-6-syntaxin-16-Vti1a complex", "definition": "A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof). [PMID:11839770]"}
{"concept_id": "C2610714", "aliases": ["SNARE complex location (Vamp4, Stx6, Stx16, Vti1a)"], "types": ["T026"], "canonical_name": "SNARE complex (Vamp4, Stx6, Stx16, Vti1a)"}
{"concept_id": "C2610715", "aliases": ["Vamp4-Stx6-Stx16-Vti1a complex location"], "types": ["T026"], "canonical_name": "Vamp4-Stx6-Stx16-Vti1a complex"}
{"concept_id": "C2610716", "aliases": ["cytochrome complex location"], "types": ["T026"], "canonical_name": "cytochrome complex", "definition": "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. [GOC:mah]"}
{"concept_id": "C2610717", "aliases": [], "types": ["T044"], "canonical_name": "proton-transporting V-type ATPase complex assembly", "definition": "The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. [GOC:mah]"}
{"concept_id": "C2610718", "aliases": ["V-ATPase assembly"], "types": ["T044"], "canonical_name": "V-ATPase assembly"}
{"concept_id": "C2610719", "aliases": ["V-ATPase complex assembly"], "types": ["T044"], "canonical_name": "V-ATPase complex assembly"}
{"concept_id": "C2610720", "aliases": [], "types": ["T044"], "canonical_name": "proton-transporting two-sector ATPase complex assembly", "definition": "The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. [GOC:mah]"}
{"concept_id": "C2610721", "aliases": [], "types": ["T044"], "canonical_name": "vacuolar proton-transporting V-type ATPase complex assembly", "definition": "The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610722", "aliases": ["clustering of voltage gated calcium channels", "clustering of voltage-dependent calcium channels", "voltage-gated calcium channel clustering"], "types": ["T043"], "canonical_name": "clustering of voltage-gated calcium channels", "definition": "The process in which voltage-gated calcium channels become localized together in high densities. [GOC:BHF, GOC:sart, PMID:18385325]"}
{"concept_id": "C2610723", "aliases": [], "types": ["T026"], "canonical_name": "mononeme", "definition": "A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts. [GOC:BHF, PMID:18048320]"}
{"concept_id": "C2610724", "aliases": [], "types": ["T042"], "definition": "The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium. [GOC:rph]", "canonical_name": "tear secretion"}
{"concept_id": "C2610725", "aliases": [], "types": ["T044"], "canonical_name": "histone lysine demethylation", "definition": "The modification of a histone by the removal of a methyl group from a lysine residue. [GOC:mah]"}
{"concept_id": "C2610726", "aliases": [], "types": ["T044"], "canonical_name": "histone arginine demethylation", "definition": "The modification of a histone by the removal of a methyl group from an arginine residue. [GOC:mah]"}
{"concept_id": "C2610727", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-R2 demethylation", "definition": "The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2610728", "aliases": [], "types": ["T044"], "canonical_name": "histone H4-R3 demethylation", "definition": "The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2610729", "aliases": ["Z repeat domain binding"], "types": ["T044"], "canonical_name": "titin Z domain binding", "definition": "Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. [GOC:mah, InterPro:IPR015129]"}
{"concept_id": "C2610733", "aliases": ["removal of initiator methionine from protein"], "types": ["T044"], "canonical_name": "protein initiator methionine removal", "definition": "The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein. [GOC:imk, GOC:mah]"}
{"concept_id": "C2610734", "aliases": ["ubiquitin-mediated endocytosis"], "types": ["T043"], "canonical_name": "ubiquitin-dependent endocytosis", "definition": "Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded. [GOC:jp, GOC:mah, PMID:9409540]"}
{"concept_id": "C2610735", "aliases": ["chromoshadow domain binding"], "types": ["T044"], "canonical_name": "chromo shadow domain binding", "definition": "Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. [GOC:BHF, GOC:vk, InterPro:IPR008251, PMID:7667093]"}
{"concept_id": "C2610736", "aliases": ["polyhydroxyalkanoate granule"], "types": ["T026"], "canonical_name": "PHA granule", "definition": "An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR. [GOC:mah, PMID:15762612]"}
{"concept_id": "C2610737", "aliases": [], "types": ["T026"], "canonical_name": "PHB granule"}
{"concept_id": "C2610738", "aliases": [], "types": ["T044"], "canonical_name": "chloride-activated potassium channel activity", "definition": "Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. [GOC:kmv, GOC:mtg_transport]"}
{"concept_id": "C2610739", "aliases": [], "types": ["T043"], "canonical_name": "glucagon secretion", "definition": "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). [GOC:BHF, GOC:rl]"}
{"concept_id": "C2610740", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glucagon secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of glucagon. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610741", "aliases": ["down-regulation of glucagon secretion", "downregulation of glucagon secretion", "down regulation of glucagon secretion"], "types": ["T043"], "canonical_name": "negative regulation of glucagon secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610742", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glucagon secretion"}
{"concept_id": "C2610743", "aliases": ["up-regulation of glucagon secretion", "up regulation of glucagon secretion", "upregulation of glucagon secretion"], "types": ["T043"], "canonical_name": "positive regulation of glucagon secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610744", "aliases": ["stimulation of glucagon secretion"], "types": ["T043"], "canonical_name": "activation of glucagon secretion"}
{"concept_id": "C2610745", "aliases": ["fructose 6-phosphate binding"], "types": ["T044"], "canonical_name": "fructose-6-phosphate binding", "definition": "Binding to fructose 6-phosphate. [GOC:mah]"}
{"concept_id": "C2610746", "aliases": [], "types": ["T044"], "canonical_name": "D-fructose 6-phosphate binding"}
{"concept_id": "C2610747", "aliases": ["mitochondrion outer membrane translocase complex assembly", "TOM complex assembly"], "types": ["T044"], "canonical_name": "mitochondrial outer membrane translocase complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2610748", "aliases": [], "types": ["T044"], "canonical_name": "delta-catenin binding", "definition": "Binding to the delta subunit of the catenin complex. [GOC:rph]"}
{"concept_id": "C2610749", "aliases": ["chemokine-mediated signalling pathway"], "types": ["T043"], "canonical_name": "chemokine-mediated signaling pathway", "definition": "The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]"}
{"concept_id": "C2610750", "aliases": ["regulation of chemokine-mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of chemokine-mediated signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of a chemokine-mediated signaling pathway. [GOC:mah]"}
{"concept_id": "C2610751", "aliases": ["negative regulation of chemokine-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of chemokine-mediated signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of a chemokine-mediated signaling pathway. [GOC:mah]"}
{"concept_id": "C2610752", "aliases": ["positive regulation of chemokine-mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of chemokine-mediated signaling pathway", "definition": "Any process that increases the rate, frequency or extent of a chemokine-mediated signaling pathway. [GOC:mah]"}
{"concept_id": "C2610753", "aliases": ["interleukin-6-mediated signalling pathway", "IL-6-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-6-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]"}
{"concept_id": "C2610754", "aliases": ["regulation of interleukin-6-mediated signalling pathway", "regulation of IL-6-mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of interleukin-6-mediated signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of an interleukin-6-mediated signaling pathway. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610755", "aliases": ["negative regulation of IL-6-mediated signaling pathway", "negative regulation of interleukin-6-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of interleukin-6-mediated signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610756", "aliases": ["positive regulation of interleukin-6-mediated signalling pathway", "positive regulation of IL-6-mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of interleukin-6-mediated signaling pathway", "definition": "Any process that increases the rate, frequency or extent of an interleukin-6-mediated signaling pathway. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610757", "aliases": ["IL-27-mediated signaling pathway", "interleukin-27-mediated signalling pathway", "IL27RA/IL6ST signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-27-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-27 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]"}
{"concept_id": "C2610758", "aliases": ["regulation of interleukin-27-mediated signalling pathway", "regulation of IL27RA/IL6ST signaling pathway", "regulation of IL-27-mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of interleukin-27-mediated signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of an interleukin-27-mediated signaling pathway. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610760", "aliases": ["negative regulation of IL-27-mediated signaling pathway", "negative regulation of IL27RA/IL6ST signaling pathway", "negative regulation of interleukin-27-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of interleukin-27-mediated signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of an interleukin-27-mediated signaling pathway. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610761", "aliases": ["positive regulation of IL27RA/IL6ST signaling pathway", "positive regulation of IL-27-mediated signaling pathway", "positive regulation of interleukin-27-mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of interleukin-27-mediated signaling pathway", "definition": "Any process that increases the rate, frequency or extent of an interleukin-27-mediated signaling pathway. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610762", "aliases": ["ciliary neurotrophic factor receptor complex location"], "types": ["T026"], "canonical_name": "ciliary neurotrophic factor receptor complex", "definition": "A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR. [GOC:BHF, GOC:mah, GOC:rl, PMID:12707266]"}
{"concept_id": "C2610763", "aliases": ["Paulinella-type chromatophore"], "types": ["T026"], "canonical_name": "organellar chromatophore", "definition": "A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora. [GOC:expert_mm, PMID:18356055]"}
{"concept_id": "C2610764", "aliases": ["Paulinella-type chromatophore membrane"], "types": ["T026"], "canonical_name": "organellar chromatophore membrane", "definition": "Either of the lipid bilayers that surround an organellar chromatophore. [GOC:mah]"}
{"concept_id": "C2610765", "aliases": ["Paulinella-type chromatophore inner membrane"], "types": ["T026"], "canonical_name": "organellar chromatophore inner membrane", "definition": "The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore. [GOC:mah]"}
{"concept_id": "C2610766", "aliases": ["Paulinella-type chromatophore outer membrane"], "types": ["T026"], "canonical_name": "organellar chromatophore outer membrane", "definition": "The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore. [GOC:mah]"}
{"concept_id": "C2610767", "aliases": ["Paulinella-type chromatophore intermembrane space"], "types": ["T026"], "canonical_name": "organellar chromatophore intermembrane space", "definition": "The region between the inner and outer lipid bilayers that surround an organellar chromatophore. [GOC:mah]"}
{"concept_id": "C2610768", "aliases": ["Paulinella-type chromatophore thylakoid"], "types": ["T026"], "canonical_name": "organellar chromatophore thylakoid", "definition": "A thylakoid located in an organellar chromatophore. [GOC:mah]"}
{"concept_id": "C2610769", "aliases": ["Paulinella-type chromatophore thylakoid lumen"], "types": ["T026"], "canonical_name": "organellar chromatophore thylakoid lumen", "definition": "The volume enclosed by an organellar chromatophore thylakoid membrane. [GOC:mah]"}
{"concept_id": "C2610770", "aliases": ["Paulinella-type chromatophore thylakoid membrane"], "types": ["T026"], "canonical_name": "organellar chromatophore thylakoid membrane", "definition": "The lipid bilayer membrane of any thylakoid within an organellar chromatophore. [GOC:mah]"}
{"concept_id": "C2610771", "aliases": ["CNTF binding"], "types": ["T044"], "canonical_name": "ciliary neurotrophic factor binding", "definition": "Binding to the cytokine ciliary neurotrophic factor. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610772", "aliases": ["ciliary neurotrophic factor-mediated signalling pathway", "CNTF-mediated signaling pathway"], "types": ["T043"], "canonical_name": "ciliary neurotrophic factor-mediated signaling pathway", "definition": "The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610773", "aliases": ["KV development"], "types": ["T042"], "canonical_name": "Kupffer's vesicle development", "definition": "The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period. [GOC:dgh]"}
{"concept_id": "C2610775", "aliases": ["type III TGFbeta receptor activity", "type III TGF-beta receptor activity", "type III transforming growth factor beta receptor activity"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor activity, type III", "definition": "Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. [GOC:BHF, GOC:mah, PMID:9759503]"}
{"concept_id": "C2610776", "aliases": [], "types": ["T044"], "canonical_name": "betaglycan"}
{"concept_id": "C2610777", "aliases": [], "types": ["T044"], "canonical_name": "endoglin"}
{"concept_id": "C2610778", "aliases": ["transforming growth factor beta ligand binding to type III receptor"], "types": ["T044"], "canonical_name": "transforming growth factor beta ligand binding to type III receptor"}
{"concept_id": "C2610779", "aliases": ["mitochondrial translation initiation"], "types": ["T045"], "canonical_name": "mitochondrial translational initiation", "definition": "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. [GOC:mah]"}
{"concept_id": "C2610780", "aliases": ["mitochondrial translation elongation"], "types": ["T045"], "canonical_name": "mitochondrial translational elongation", "definition": "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion. [GOC:mah]"}
{"concept_id": "C2610781", "aliases": ["mitochondrial translation termination"], "types": ["T045"], "canonical_name": "mitochondrial translational termination", "definition": "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa). [GOC:mah, http://mitogenome.org/index.php/Genetic_Code_of_mitochondria]"}
{"concept_id": "C2610782", "aliases": [], "types": ["T045"], "canonical_name": "tRNA aminoacylation for mitochondrial protein translation", "definition": "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion. [GOC:mah]"}
{"concept_id": "C2610784", "aliases": ["regulation of mitochondrial protein biosynthesis", "regulation of mitochondrial protein anabolism", "regulation of mitochondrial protein formation", "regulation of mitochondrial protein synthesis"], "types": ["T043"], "canonical_name": "regulation of mitochondrial translation", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. [GOC:mah]"}
{"concept_id": "C2610785", "aliases": ["negative regulation of mitochondrial protein synthesis", "negative regulation of mitochondrial protein anabolism", "negative regulation of mitochondrial protein biosynthesis", "negative regulation of mitochondrial protein formation"], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial translation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. [GOC:mah]"}
{"concept_id": "C2610786", "aliases": ["positive regulation of mitochondrial protein biosynthesis", "positive regulation of mitochondrial protein formation", "positive regulation of mitochondrial protein synthesis", "positive regulation of mitochondrial protein anabolism"], "types": ["T045"], "canonical_name": "positive regulation of mitochondrial translation", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. [GOC:mah]"}
{"concept_id": "C2610787", "aliases": ["regulation of mitochondrial translation initiation"], "types": ["T043"], "canonical_name": "regulation of mitochondrial translational initiation", "definition": "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. [GOC:mah]"}
{"concept_id": "C2610788", "aliases": ["negative regulation of mitochondrial translation initiation"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial translational initiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. [GOC:mah]"}
{"concept_id": "C2610789", "aliases": ["positive regulation of mitochondrial translation initiation"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial translational initiation", "definition": "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. [GOC:mah]"}
{"concept_id": "C2610790", "aliases": ["beta-1,2-oligomannoside metabolism"], "types": ["T043"], "canonical_name": "beta-1,2-oligomannoside metabolic process", "definition": "The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan. [GOC:mah, PMID:18234669]"}
{"concept_id": "C2610791", "aliases": ["beta-1,2-oligomannoside anabolism", "beta-1,2-oligomannoside formation", "beta-1,2-oligomannoside biosynthesis", "beta-1,2-oligomannoside synthesis"], "types": ["T044"], "canonical_name": "beta-1,2-oligomannoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan. [GOC:mah, PMID:18234669]"}
{"concept_id": "C2610792", "aliases": ["small conjugating protein-specific endopeptidase activity"], "types": ["T044"], "canonical_name": "ubiquitin-like protein-specific endopeptidase activity", "definition": "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO). [GOC:mah]"}
{"concept_id": "C2610794", "aliases": [], "types": ["T044"], "canonical_name": "SUMO-specific endopeptidase activity", "definition": "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO. [GOC:mah]"}
{"concept_id": "C2610796", "aliases": ["response to UV-A radiation stimulus", "response to UV-A light stimulus", "response to UVA radiation stimulus", "response to UVA light stimulus"], "types": ["T038"], "canonical_name": "response to UV-A", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610797", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle budding", "definition": "Evagination of a membrane to form a synaptic vesicle. [GOC:mah]"}
{"concept_id": "C2610798", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial alanyl-tRNA aminoacylation", "definition": "The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610799", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial arginyl-tRNA aminoacylation", "definition": "The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610800", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial asparaginyl-tRNA aminoacylation", "definition": "The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610801", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial aspartyl-tRNA aminoacylation", "definition": "The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610802", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial cysteinyl-tRNA aminoacylation", "definition": "The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610803", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial glutaminyl-tRNA aminoacylation", "definition": "The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610804", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial glutamyl-tRNA aminoacylation", "definition": "The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610805", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial glycyl-tRNA aminoacylation", "definition": "The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610806", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial histidyl-tRNA aminoacylation", "definition": "The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610807", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial isoleucyl-tRNA aminoacylation", "definition": "The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610808", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial leucyl-tRNA aminoacylation", "definition": "The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610809", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial lysyl-tRNA aminoacylation", "definition": "The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610810", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial methionyl-tRNA aminoacylation", "definition": "The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610811", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial phenylalanyl-tRNA aminoacylation", "definition": "The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610812", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial prolyl-tRNA aminoacylation", "definition": "The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610813", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial seryl-tRNA aminoacylation", "definition": "The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610814", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial threonyl-tRNA aminoacylation", "definition": "The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610815", "aliases": [], "types": ["T042"], "canonical_name": "adiponectin secretion", "definition": "The regulated release of adiponectin, a protein hormone, by adipose tissue. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2610816", "aliases": [], "types": ["T043"], "canonical_name": "regulation of adiponectin secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell. [GOC:mah]"}
{"concept_id": "C2610817", "aliases": ["down regulation of adiponectin secretion", "down-regulation of adiponectin secretion", "downregulation of adiponectin secretion"], "types": ["T043"], "canonical_name": "negative regulation of adiponectin secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610818", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adiponectin secretion"}
{"concept_id": "C2610819", "aliases": ["up-regulation of adiponectin secretion", "upregulation of adiponectin secretion", "up regulation of adiponectin secretion"], "types": ["T043"], "canonical_name": "positive regulation of adiponectin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610820", "aliases": [], "types": ["T043"], "canonical_name": "activation of adiponectin secretion"}
{"concept_id": "C2610821", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of adiponectin secretion"}
{"concept_id": "C2610822", "aliases": [], "types": ["T042"], "canonical_name": "enamel mineralization", "definition": "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. [GOC:BHF, GOC:mah, GOC:sl, PMID:10206335, PMID:16931858, PMID:21196346]"}
{"concept_id": "C2610823", "aliases": [], "types": ["T038"], "canonical_name": "regulation of biomineral tissue development", "definition": "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. [GOC:mah]"}
{"concept_id": "C2610824", "aliases": [], "types": ["T038"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. [GOC:mah]", "canonical_name": "negative regulation of biomineral tissue development"}
{"concept_id": "C2610825", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of biomineral tissue development", "definition": "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. [GOC:mah]"}
{"concept_id": "C2610826", "aliases": [], "types": ["T042"], "canonical_name": "regulation of tooth mineralization", "definition": "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610827", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of tooth mineralization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610828", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of tooth mineralization", "definition": "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610829", "aliases": [], "types": ["T042"], "canonical_name": "regulation of enamel mineralization", "definition": "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610830", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of enamel mineralization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610831", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of enamel mineralization", "definition": "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610832", "aliases": ["DRM complex location", "DP/Rb/MuvB"], "types": ["T026"], "canonical_name": "DRM complex", "definition": "A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification. [PMID:17075059]"}
{"concept_id": "C2610833", "aliases": [], "types": ["T043"], "canonical_name": "contractile vacuole discharge", "definition": "The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane. [GOC:mah, PMID:10369671]"}
{"concept_id": "C2610834", "aliases": ["D-serine metabolism"], "types": ["T044"], "canonical_name": "D-serine metabolic process", "definition": "The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. [CHEBI:16523, GOC:jsg, GOC:mah]"}
{"concept_id": "C2610835", "aliases": ["D-serine anabolism", "D-serine biosynthesis", "D-serine formation", "D-serine synthesis"], "types": ["T044"], "canonical_name": "D-serine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine. [CHEBI:16523, GOC:jsg, GOC:mah]"}
{"concept_id": "C2610836", "aliases": ["25S rRNA binding", "LSU rRNA binding"], "types": ["T045"], "canonical_name": "large ribosomal subunit rRNA binding", "definition": "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA. [GOC:elh]"}
{"concept_id": "C2610837", "aliases": ["18S rRNA binding", "SSU rRNA binding"], "types": ["T045"], "canonical_name": "small ribosomal subunit rRNA binding", "definition": "Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. [GOC:elh]"}
{"concept_id": "C2610838", "aliases": [], "types": ["T044"], "canonical_name": "DNA polymerase binding", "definition": "Binding to a DNA polymerase. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610839", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tryptophanyl-tRNA aminoacylation", "definition": "The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610840", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tyrosyl-tRNA aminoacylation", "definition": "The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610841", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial valyl-tRNA aminoacylation", "definition": "The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2610842", "aliases": [], "types": ["T044"], "canonical_name": "pituitary growth hormone activity"}
{"concept_id": "C2610843", "aliases": [], "types": ["T044"], "canonical_name": "placental growth hormone activity"}
{"concept_id": "C2610844", "aliases": ["telosome", "Pot1-Tpz1 complex location", "Pot1-Tpz1 complex", "shelterin complex location", "shelterin complex", "Pot1 complex"], "types": ["T026"], "definition": "A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1. [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880]", "canonical_name": "Pot1 complex location"}
{"concept_id": "C2610846", "aliases": ["kynurenine metabolism"], "types": ["T044"], "canonical_name": "kynurenine metabolic process", "definition": "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine. [CHEBI:28683, GOC:mah, GOC:rph]"}
{"concept_id": "C2610848", "aliases": [], "types": ["T044"], "canonical_name": "methionine-R-sulfoxide reductase activity", "definition": "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin. [GOC:mcc, PMID:17535911, PMID:19049972]"}
{"concept_id": "C2610849", "aliases": ["meiotic chromosome organization", "chromosome organisation involved in meiosis"], "types": ["T043"], "canonical_name": "chromosome organization involved in meiotic cell cycle", "definition": "A process of chromosome organization that is involved in a meiotic cell cycle. [GOC:mah]"}
{"concept_id": "C2610850", "aliases": ["synaptonemal complex organisation"], "types": ["T043"], "canonical_name": "synaptonemal complex organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. [GOC:mah]"}
{"concept_id": "C2610851", "aliases": [], "types": ["T043"], "canonical_name": "synaptonemal complex disassembly", "definition": "The controlled breakdown of a synaptonemal complex. [GOC:mah]"}
{"concept_id": "C2610852", "aliases": ["growth hormone receptor complex location"], "types": ["T026"], "canonical_name": "growth hormone receptor complex", "definition": "A receptor complex that consists of two identical subunits and binds growth hormone. [GOC:BHF, GOC:mah, GOC:vk, PMID:11445442]"}
{"concept_id": "C2610853", "aliases": ["eIF3 assembly", "eIF-3 assembly"], "types": ["T044"], "canonical_name": "eukaryotic translation initiation factor 3 complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex. [GOC:mah]"}
{"concept_id": "C2610854", "aliases": ["attachment of telomeres to nuclear envelope"], "types": ["T043"], "definition": "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation. [GOC:jp, GOC:pr, GOC:vw, PMID:18818742]", "canonical_name": "meiotic attachment of telomere to nuclear envelope"}
{"concept_id": "C2610855", "aliases": ["protein localisation to chromosome, telomeric region", "protein localization to telomere"], "types": ["T043"], "canonical_name": "protein localization to chromosome, telomeric region", "definition": "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610856", "aliases": ["establishment of protein localisation to chromosome"], "types": ["T043"], "canonical_name": "establishment of protein localization to chromosome", "definition": "The directed movement of a protein to a specific location on a chromosome. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610857", "aliases": ["establishment of protein localisation to telomere", "establishment of protein localization to chromosome, telomeric region"], "types": ["T043"], "canonical_name": "establishment of protein localization to telomere", "definition": "The directed movement of a protein to a specific location in the telomeric region of a chromosome. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610858", "aliases": ["regulation of establishment of protein localisation"], "types": ["T039"], "canonical_name": "regulation of establishment of protein localization", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610859", "aliases": ["regulation of establishment of protein localisation to chromosome"], "types": ["T039"], "canonical_name": "regulation of establishment of protein localization to chromosome", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610860", "aliases": ["regulation of establishment of protein localisation to telomere"], "types": ["T039"], "canonical_name": "regulation of establishment of protein localization to telomere", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2610861", "aliases": ["MenD", "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2). [RHEA:25593]", "canonical_name": "SEPHCHC synthase activity"}
{"concept_id": "C2610862", "aliases": ["protein homotrimer assembly", "protein homotrimer biosynthetic process", "protein homotrimer formation", "protein homotrimer biosynthesis"], "types": ["T044"], "canonical_name": "protein homotrimerization", "definition": "The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. [GOC:hjd]"}
{"concept_id": "C2610863", "aliases": ["protein heterotrimer biosynthetic process", "protein heterotrimer assembly", "protein heterotrimer formation", "protein heterotrimer biosynthesis"], "types": ["T044"], "canonical_name": "protein heterotrimerization", "definition": "The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. [GOC:hjd]"}
{"concept_id": "C2610864", "aliases": ["ASTRA complex location"], "types": ["T026"], "canonical_name": "ASTRA complex", "definition": "A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p. [GOC:rb, PMID:19040720, PMID:22505622]"}
{"concept_id": "C2610865", "aliases": ["Clr6-LE complex", "Clr6-LE complex location", "Rpd3L-Expanded complex location"], "types": ["T026"], "canonical_name": "Rpd3L-Expanded complex", "definition": "A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins. [GOC:rb, PMID:19040720]"}
{"concept_id": "C2610866", "aliases": ["Snt2C complex location"], "types": ["T026"], "canonical_name": "Snt2C complex", "definition": "A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p. [GOC:rb, PMID:19040720]"}
{"concept_id": "C2610867", "aliases": ["protein amino acid poly-ADP-ribosylation", "poly(ADP-ribose) addition to protein", "addition of poly-ADP-ribose to protein", "protein poly(ADP-ribose) synthesis"], "types": ["T044"], "canonical_name": "protein poly-ADP-ribosylation", "definition": "The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]"}
{"concept_id": "C2610868", "aliases": [], "types": ["T044"], "canonical_name": "protein poly(ADP-ribose) metabolism"}
{"concept_id": "C2610869", "aliases": ["protein amino acid auto-ADP-ribosylation"], "types": ["T044"], "canonical_name": "protein auto-ADP-ribosylation", "definition": "The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2610870", "aliases": ["CSK-GAP-A.p62 complex location"], "types": ["T026"], "canonical_name": "CSK-GAP-A.p62 complex", "definition": "A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation. [PMID:7544435]"}
{"concept_id": "C2610873", "aliases": ["TFIIIB assembly"], "types": ["T044"], "canonical_name": "transcription factor TFIIIB complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex. [GOC:mah]"}
{"concept_id": "C2610874", "aliases": ["sulphide homeostasis", "sulfide homeostasis", "sulphide ion homeostasis"], "types": ["T043"], "canonical_name": "sulfide ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of sulfide ions within an organism or cell. [GOC:mah]"}
{"concept_id": "C2610875", "aliases": ["sulphide generation"], "types": ["T043"], "canonical_name": "sulfide generation"}
{"concept_id": "C2610876", "aliases": ["sulphide production"], "types": ["T043"], "canonical_name": "sulfide production"}
{"concept_id": "C2610877", "aliases": ["cellular sulphide ion homeostasis", "cellular sulphide homeostasis", "cellular sulfide homeostasis"], "types": ["T043"], "canonical_name": "cellular sulfide ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of sulfide ions at the level of a cell. [GOC:mah]"}
{"concept_id": "C2610878", "aliases": ["aerobic sulphur oxidation"], "types": ["T044"], "canonical_name": "aerobic sulfur oxidation", "definition": "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen. [MetaCyc:SULFUROX-PWY]"}
{"concept_id": "C2610879", "aliases": ["sulfide oxidation, using sulfide-quinone reductase", "sulphide oxidation, using sulfide:quinone oxidoreductase"], "types": ["T044"], "canonical_name": "sulfide oxidation, using sulfide:quinone oxidoreductase", "definition": "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase. [MetaCyc:P222-PWY]"}
{"concept_id": "C2610880", "aliases": ["sulphide oxidation, using sulfide dehydrogenase"], "types": ["T044"], "canonical_name": "sulfide oxidation, using sulfide dehydrogenase", "definition": "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase. [MetaCyc:PWY-5274]"}
{"concept_id": "C2610881", "aliases": ["sulphide oxidation, using sulfur dioxygenase"], "types": ["T044"], "canonical_name": "sulfide oxidation, using sulfur dioxygenase", "definition": "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase. [MetaCyc:PWY-5285]"}
{"concept_id": "C2610882", "aliases": ["sulfide-quinone reductase activity", "sulphide:quinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "sulfide:quinone oxidoreductase activity", "definition": "Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone. [MetaCyc:R17-RXN]"}
{"concept_id": "C2610883", "aliases": ["flavocytochrome c sulfide dehydrogenase activity", "sulphide dehydrogenase activity"], "types": ["T044"], "canonical_name": "sulfide dehydrogenase activity", "definition": "Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c. [RHEA:30223]"}
{"concept_id": "C2610884", "aliases": ["hydrogen sulfide:ferric ion oxidoreductase"], "types": ["T044"], "canonical_name": "sulfur:ferric ion oxidoreductase activity", "definition": "Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+. [MetaCyc:SULFFEOXIDO-RXN]"}
{"concept_id": "C2610886", "aliases": ["regulation of lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "regulation of lymphocyte apoptotic process", "definition": "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610888", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lymphocyte apoptosis"}
{"concept_id": "C2610890", "aliases": ["stimulation of lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "activation of lymphocyte apoptosis"}
{"concept_id": "C2610891", "aliases": ["T cell apoptosis", "T-lymphocyte apoptosis", "T lymphocyte apoptosis", "programmed cell death of T cells by apoptosis", "T-cell apoptosis"], "types": ["T043"], "canonical_name": "T cell apoptotic process", "definition": "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610892", "aliases": ["regulation of T lymphocyte apoptosis", "regulation of programmed cell death of T cells by apoptosis", "regulation of T-lymphocyte apoptosis", "regulation of T cell apoptosis", "regulation of T-cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of T cell apoptotic process", "definition": "Any process that modulates the occurrence or rate of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610893", "aliases": ["downregulation of T cell apoptosis", "down regulation of T cell apoptosis", "negative regulation of T lymphocyte apoptosis", "negative regulation of T-lymphocyte apoptosis", "down-regulation of T cell apoptosis", "negative regulation of T cell apoptosis", "negative regulation of programmed cell death of T cells by apoptosis", "negative regulation of T-cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of T cell apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610894", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of T cell apoptosis"}
{"concept_id": "C2610895", "aliases": ["positive regulation of T lymphocyte apoptosis", "up-regulation of T cell apoptosis", "positive regulation of programmed cell death of T cells by apoptosis", "upregulation of T cell apoptosis", "positive regulation of T-lymphocyte apoptosis", "positive regulation of T-cell apoptosis", "up regulation of T cell apoptosis", "positive regulation of T cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of T cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610896", "aliases": ["stimulation of T cell apoptosis"], "types": ["T043"], "canonical_name": "activation of T cell apoptosis"}
{"concept_id": "C2610897", "aliases": ["regulation of activation-induced cell death of T-cells", "regulation of activation-induced cell death of T lymphocytes", "regulation of activation-induced cell death of T-lymphocytes"], "types": ["T043"], "canonical_name": "regulation of activation-induced cell death of T cells", "definition": "Any process that modulates the occurrence or rate of activation-induced cell death of T cells. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2610898", "aliases": ["regulation of activated T cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of activated T cell apoptosis"}
{"concept_id": "C2610899", "aliases": ["regulation of AICD", "regulation of activation-induced cell death"], "types": ["T043"], "canonical_name": "regulation of AICD"}
{"concept_id": "C2610900", "aliases": [], "types": ["T043"], "canonical_name": "regulation of antigen-driven apoptosis"}
{"concept_id": "C2610901", "aliases": ["downregulation of activation-induced cell death of T cells", "negative regulation of activation-induced cell death of T-lymphocytes", "negative regulation of activation-induced cell death of T lymphocytes", "down-regulation of activation-induced cell death of T cells", "negative regulation of activation-induced cell death of T-cells", "down regulation of activation-induced cell death of T cells"], "types": ["T043"], "canonical_name": "negative regulation of activation-induced cell death of T cells", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2610902", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of activation-induced cell death of T cells"}
{"concept_id": "C2610903", "aliases": ["negative regulation of activated T cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of activated T cell apoptosis"}
{"concept_id": "C2610904", "aliases": ["negative regulation of AICD", "negative regulation of activation-induced cell death"], "types": ["T043"], "canonical_name": "negative regulation of AICD"}
{"concept_id": "C2610905", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of antigen-driven apoptosis"}
{"concept_id": "C2610906", "aliases": ["up-regulation of activation-induced cell death of T cells", "upregulation of activation-induced cell death of T cells", "positive regulation of activation-induced cell death of T-lymphocytes", "positive regulation of activation-induced cell death of T-cells", "up regulation of activation-induced cell death of T cells", "positive regulation of activation-induced cell death of T lymphocytes"], "types": ["T043"], "canonical_name": "positive regulation of activation-induced cell death of T cells", "definition": "Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2610907", "aliases": [], "types": ["T043"], "canonical_name": "activation of activation-induced cell death of T cells"}
{"concept_id": "C2610908", "aliases": ["positive regulation of activated T cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of activated T cell apoptosis"}
{"concept_id": "C2610909", "aliases": ["positive regulation of activation-induced cell death", "positive regulation of AICD"], "types": ["T043"], "canonical_name": "positive regulation of AICD"}
{"concept_id": "C2610910", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of antigen-driven apoptosis"}
{"concept_id": "C2610911", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of activation-induced cell death of T cells"}
{"concept_id": "C2610912", "aliases": [], "types": ["T043"], "canonical_name": "activated cell autonomous cell death"}
{"concept_id": "C2610913", "aliases": ["regulation of activated T lymphocyte autonomous cell death", "regulation of activated T-cell autonomous cell death", "regulation of activated T-lymphocyte autonomous cell death"], "types": ["T043"], "canonical_name": "regulation of activated T cell autonomous cell death", "definition": "Any process that modulates the occurrence or rate of activated T cell autonomous cell death. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610914", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ACAD"}
{"concept_id": "C2610915", "aliases": [], "types": ["T043"], "canonical_name": "regulation of activated cell autonomous cell death"}
{"concept_id": "C2610916", "aliases": ["negative regulation of activated T lymphocyte autonomous cell death", "down-regulation of activated T cell autonomous cell death", "negative regulation of activated T-cell autonomous cell death", "negative regulation of activated T-lymphocyte autonomous cell death", "downregulation of activated T cell autonomous cell death", "down regulation of activated T cell autonomous cell death"], "types": ["T043"], "canonical_name": "negative regulation of activated T cell autonomous cell death", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610917", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of activated T cell autonomous cell death"}
{"concept_id": "C2610918", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ACAD"}
{"concept_id": "C2610919", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of activated cell autonomous cell death"}
{"concept_id": "C2610920", "aliases": ["upregulation of activated T cell autonomous cell death", "up regulation of activated T cell autonomous cell death", "positive regulation of activated T-cell autonomous cell death", "positive regulation of activated T-lymphocyte autonomous cell death", "up-regulation of activated T cell autonomous cell death", "positive regulation of activated T lymphocyte autonomous cell death"], "types": ["T043"], "canonical_name": "positive regulation of activated T cell autonomous cell death", "definition": "Any process that activates or increases the frequency, rate or extent of activated T cell autonomous cell death. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610921", "aliases": [], "types": ["T043"], "canonical_name": "activation of activated T cell autonomous cell death"}
{"concept_id": "C2610922", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ACAD"}
{"concept_id": "C2610923", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of activated cell autonomous cell death"}
{"concept_id": "C2610924", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of activated T cell autonomous cell death"}
{"concept_id": "C2610925", "aliases": ["thymocyte apoptosis"], "types": ["T043"], "canonical_name": "thymocyte apoptotic process", "definition": "Any apoptotic process in a thymocyte, an immature T cell located in the thymus. [CL:0000893, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610926", "aliases": [], "types": ["T043"], "canonical_name": "immature T cell apoptosis"}
{"concept_id": "C2610927", "aliases": ["regulation of thymocyte apoptosis"], "types": ["T043"], "canonical_name": "regulation of thymocyte apoptotic process", "definition": "Any process that modulates the occurrence or rate of thymocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610928", "aliases": [], "types": ["T043"], "canonical_name": "regulation of immature T cell apoptosis"}
{"concept_id": "C2610930", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of thymocyte apoptosis"}
{"concept_id": "C2610931", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of immature T cell apoptosis"}
{"concept_id": "C2610933", "aliases": [], "types": ["T043"], "canonical_name": "activation of thymocyte apoptosis"}
{"concept_id": "C2610934", "aliases": ["positive regulation of immature T cell apoptosis", "up-regulation of thymocyte apoptosis", "up regulation of thymocyte apoptosis", "upregulation of thymocyte apoptosis", "positive regulation of thymocyte apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of thymocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610935", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of thymocyte apoptosis"}
{"concept_id": "C2610936", "aliases": ["NK cell apoptosis", "natural killer cell apoptosis"], "types": ["T043"], "canonical_name": "natural killer cell apoptotic process", "definition": "Any apoptotic process in a natural killer cell, a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation. [CL:0000623, GOC:add, GOC:mtg_apoptosis, PMID:15728472]"}
{"concept_id": "C2610937", "aliases": ["regulation of natural killer cell apoptosis", "regulation of NK cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of natural killer cell apoptotic process", "definition": "Any process that modulates the occurrence or rate of natural killer cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610938", "aliases": ["down regulation of natural killer cell apoptosis", "downregulation of natural killer cell apoptosis", "negative regulation of NK cell apoptosis", "down-regulation of natural killer cell apoptosis", "negative regulation of natural killer cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610939", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of natural killer cell apoptosis"}
{"concept_id": "C2610940", "aliases": ["upregulation of natural killer cell apoptosis", "positive regulation of natural killer cell apoptosis", "up regulation of natural killer cell apoptosis", "up-regulation of natural killer cell apoptosis", "positive regulation of NK cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C2610941", "aliases": ["stimulation of natural killer cell apoptosis"], "types": ["T043"], "canonical_name": "activation of natural killer cell apoptosis"}
{"concept_id": "C2610942", "aliases": [], "types": ["T026"], "canonical_name": "mating projection membrane", "definition": "The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone. [GOC:jp]"}
{"concept_id": "C2610943", "aliases": [], "types": ["T026"], "canonical_name": "shmoo membrane"}
{"concept_id": "C2610944", "aliases": ["pristanate:CoA ligase (AMP-forming)", "pristanoyl-CoA ligase activity"], "types": ["T044"], "canonical_name": "pristanate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA. [GOC:pde, PMID:10198260]"}
{"concept_id": "C2610945", "aliases": [], "types": ["T043"], "canonical_name": "actin-mediated cell contraction", "definition": "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. [GOC:mah]"}
{"concept_id": "C2610946", "aliases": [], "types": ["T043"], "canonical_name": "somatostatin secretion", "definition": "The regulated release of somatostatin from secretory granules in the D cells of the pancreas. [GOC:mah]"}
{"concept_id": "C2610947", "aliases": ["mucus production"], "types": ["T043"], "canonical_name": "mucus secretion", "definition": "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. [GOC:add, ISBN:068340007X, ISBN:0721662544]"}
{"concept_id": "C2610948", "aliases": ["regulation of mucus production"], "types": ["T043"], "canonical_name": "regulation of mucus secretion", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. [GOC:add]"}
{"concept_id": "C2610949", "aliases": ["negative regulation of mucus production"], "types": ["T043"], "canonical_name": "negative regulation of mucus secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. [GOC:add]"}
{"concept_id": "C2610950", "aliases": ["positive regulation of mucus production"], "types": ["T043"], "canonical_name": "positive regulation of mucus secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. [GOC:add]"}
{"concept_id": "C2610951", "aliases": ["inner membrane complex location"], "types": ["T026"], "canonical_name": "inner membrane complex"}
{"concept_id": "C2610952", "aliases": [], "types": ["T044"], "canonical_name": "tyrosyl-DNA phosphodiesterase activity", "definition": "Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA. [GOC:elh, PMID:16751265]"}
{"concept_id": "C2610953", "aliases": [], "types": ["T044"], "canonical_name": "5'-tyrosyl-DNA phosphodiesterase activity", "definition": "Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA. [PMID:16751265]"}
{"concept_id": "C2610955", "aliases": [], "types": ["T040"], "canonical_name": "peptidyl-serine dephosphorylation", "definition": "The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine. [GOC:bf]"}
{"concept_id": "C2610956", "aliases": [], "types": ["T026"], "canonical_name": "external side of fungal-type cell wall", "definition": "The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents. [GOC:mah]"}
{"concept_id": "C2610957", "aliases": ["transcription factor TFIIIE complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIIE complex", "definition": "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins. [GOC:jp, PMID:19116144]"}
{"concept_id": "C2610958", "aliases": ["necroptosis", "necroptotic process"], "types": ["T043"], "definition": "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153]", "canonical_name": "RIPK1-mediated regulated necrosis"}
{"concept_id": "C2610959", "aliases": [], "types": ["T043"], "definition": "A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability). [GOC:krc, PMID:18846107]", "canonical_name": "cornification"}
{"concept_id": "C2610960", "aliases": [], "types": ["T043"], "definition": "A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. [GOC:mtg_apoptosis, PMID:18846107, PMID:21760595]", "canonical_name": "pyroptosis"}
{"concept_id": "C2610966", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-4-phosphate binding", "definition": "Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. [GOC:bf, GOC:mah]"}
{"concept_id": "C2610967", "aliases": ["RES complex location", "pre-mRNA retention and splicing complex location", "pre-mRNA retention and splicing complex"], "types": ["T045"], "canonical_name": "RES complex", "definition": "A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p. [PMID:15565172, PMID:18809678, PMID:19010333, PMID:19033360]"}
{"concept_id": "C2610968", "aliases": [], "types": ["T044"], "canonical_name": "aerobic ammonia oxidation to nitrite via pyruvic oxime", "definition": "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite. [MetaCyc:PWY-2242]"}
{"concept_id": "C2610969", "aliases": ["halogen metabolism"], "types": ["T040"], "canonical_name": "halogen metabolic process", "definition": "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds. [GOC:mah]"}
{"concept_id": "C2610970", "aliases": [], "types": ["T040"], "canonical_name": "iodide oxidation", "definition": "The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons. [GOC:mah, MetaCyc:IODIDE-PEROXIDASE-RXN]"}
{"concept_id": "C2610971", "aliases": ["ECM constituent secretion", "ECM secretion"], "types": ["T043"], "canonical_name": "extracellular matrix constituent secretion", "definition": "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell. [GOC:mah]"}
{"concept_id": "C2610972", "aliases": [], "types": ["T044"], "canonical_name": "vitamin B6 binding", "definition": "Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate. [GOC:mah]"}
{"concept_id": "C2610973", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxal binding", "definition": "Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6. [CHEBI:17310, GOC:mah]"}
{"concept_id": "C2610974", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxamine binding", "definition": "Binding to pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6. [CHEBI:16410, GOC:mah]"}
{"concept_id": "C2610975", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxine binding", "definition": "Binding to pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6. [CHEBI:16709, GOC:mah]"}
{"concept_id": "C2610976", "aliases": ["ThiC", "HMP-P synthase activity"], "types": ["T044"], "canonical_name": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity", "definition": "Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine. [PMID:18953358]"}
{"concept_id": "C2610977", "aliases": [], "types": ["T043"], "canonical_name": "pigment cell development", "definition": "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. [GOC:cvs]"}
{"concept_id": "C2610978", "aliases": ["dynein arm assembly"], "types": ["T044"], "canonical_name": "axonemal dynein complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. [GOC:cilia, GOC:mah, PMID:19052621]"}
{"concept_id": "C2610979", "aliases": ["ferritin complex receptor activity"], "types": ["T044"], "canonical_name": "ferritin receptor activity", "definition": "Combining with ferritin, and delivering ferritin into the cell via endocytosis. [GOC:bf, PMID:17459943, PMID:19154717]"}
{"concept_id": "C2610980", "aliases": ["ferritin complex location"], "types": ["T026"], "canonical_name": "ferritin complex", "definition": "A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain. [GOC:mah, PMID:19154717]"}
{"concept_id": "C2610981", "aliases": ["extracellular ferritin complex location"], "types": ["T026"], "canonical_name": "extracellular ferritin complex", "definition": "A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains. [GOC:mah, PMID:19154717]"}
{"concept_id": "C2610982", "aliases": ["serum ferritin complex location"], "types": ["T026"], "canonical_name": "serum ferritin complex"}
{"concept_id": "C2610983", "aliases": ["N-acyl-phosphatidylethanolamine-specific phospholipase D activity", "NAPE-specific phospholipase D activity"], "types": ["T044"], "canonical_name": "N-acylphosphatidylethanolamine-specific phospholipase D activity", "definition": "Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). [GOC:elh, PMID:14634025, PMID:15878693]"}
{"concept_id": "C2610984", "aliases": ["NAE metabolism", "N-acylethanolamine metabolism", "NAE metabolic process"], "types": ["T044"], "canonical_name": "N-acylethanolamine metabolic process", "definition": "The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group. [CHEBI:52640, GOC:elh, PMID:14634025, PMID:15878693]"}
{"concept_id": "C2610985", "aliases": ["N-acylphosphatidylethanolamine metabolism", "NAPE metabolic process", "NAPE metabolism"], "types": ["T044"], "canonical_name": "N-acylphosphatidylethanolamine metabolic process", "definition": "The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group. [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693]"}
{"concept_id": "C2610986", "aliases": ["renal absorption", "renal reabsorption"], "types": ["T039"], "definition": "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). [GOC:dph, GOC:mah, GOC:yaf]", "canonical_name": "nephron absorption"}
{"concept_id": "C2610987", "aliases": ["renal sodium ion reabsorption", "nephron sodium ion absorption"], "types": ["T039"], "canonical_name": "renal sodium ion absorption", "definition": "A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:dph, GOC:mah]"}
{"concept_id": "C2610988", "aliases": ["nephron water absorption", "renal water reabsorption"], "types": ["T039"], "canonical_name": "renal water absorption", "definition": "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:dph, GOC:mah]"}
{"concept_id": "C2610989", "aliases": [], "types": ["T043"], "canonical_name": "sarcoplasmic reticulum calcium ion transport", "definition": "The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2610990", "aliases": ["regulation of two-component signal transduction system", "regulation of histidyl-aspartyl phosphorelay", "regulation of two-component signal transduction system (phosphorelay)"], "types": ["T044"], "canonical_name": "regulation of phosphorelay signal transduction system", "definition": "Any process that modulates the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system. [GOC:mah]"}
{"concept_id": "C2610991", "aliases": ["negative regulation of histidyl-aspartyl phosphorelay", "down-regulation of two-component signal transduction", "down regulation of two-component signal transduction", "downregulation of two-component signal transduction", "negative regulation of two-component signal transduction system (phosphorelay)"], "types": ["T044"], "canonical_name": "negative regulation of phosphorelay signal transduction system", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system. [GOC:mah]"}
{"concept_id": "C2610992", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of two-component signal transduction"}
{"concept_id": "C2610993", "aliases": ["positive regulation of histidyl-aspartyl phosphorelay", "up regulation of two-component signal transduction", "positive regulation of two-component signal transduction system (phosphorelay)", "up-regulation of two-component signal transduction", "upregulation of two-component signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of phosphorelay signal transduction system", "definition": "Any process that activates or increases the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system. [GOC:mah]"}
{"concept_id": "C2610994", "aliases": ["stimulation of two-component signal transduction"], "types": ["T044"], "canonical_name": "activation of two-component signal transduction"}
{"concept_id": "C2610995", "aliases": ["phosphatidate binding"], "types": ["T044"], "canonical_name": "phosphatidic acid binding", "definition": "Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [CHEBI:16337, GOC:jp, ISBN:0198506732]"}
{"concept_id": "C2610996", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to hydrogen peroxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [CHEBI:16240, GOC:mah]"}
{"concept_id": "C2610997", "aliases": ["regulation of stress-activated protein kinase signaling pathway", "regulation of stress-activated protein kinase signalling pathway", "regulation of SAPK signaling pathway"], "types": ["T044"], "canonical_name": "regulation of stress-activated protein kinase signaling cascade", "definition": "Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. [GOC:mah]"}
{"concept_id": "C2610999", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of stress-activated protein kinase signaling pathway"}
{"concept_id": "C2611000", "aliases": ["stimulation of stress-activated protein kinase signaling pathway"], "types": ["T044"], "canonical_name": "activation of stress-activated protein kinase signaling pathway"}
{"concept_id": "C2611002", "aliases": ["response to cyclic GMP", "response to guanosine 3',5'-cyclophosphate", "response to 3',5'-cGMP", "response to 3',5' cGMP"], "types": ["T043"], "canonical_name": "response to cGMP", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus. [GOC:sl]"}
{"concept_id": "C2611003", "aliases": ["lens fibre cell differentiation"], "types": ["T043"], "canonical_name": "lens fiber cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. [GOC:mah, PMID:7693735]"}
{"concept_id": "C2611004", "aliases": ["lens fibre cell development"], "types": ["T043"], "canonical_name": "lens fiber cell development", "definition": "The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. [GOC:mah, PMID:7693735]"}
{"concept_id": "C2611005", "aliases": ["lens fibre cell fate commitment"], "types": ["T043"], "canonical_name": "lens fiber cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. [GOC:mah, PMID:7693735]"}
{"concept_id": "C2611006", "aliases": ["lens fibre cell morphogenesis", "lens fiber cell morphogenesis during differentiation"], "types": ["T043"], "canonical_name": "lens fiber cell morphogenesis", "definition": "The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. [GOC:mah, PMID:7693735]"}
{"concept_id": "C2611007", "aliases": [], "types": ["T043"], "canonical_name": "elongation of lens fiber cell"}
{"concept_id": "C2611008", "aliases": ["ATR-ATRIP complex location"], "types": ["T026"], "canonical_name": "ATR-ATRIP complex", "definition": "A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A. [GOC:mah, PMID:14724280]"}
{"concept_id": "C2611009", "aliases": ["Mec1-Lcd1 complex location"], "types": ["T026"], "canonical_name": "Mec1-Lcd1 complex"}
{"concept_id": "C2611010", "aliases": ["Rad3-Rad26 complex location"], "types": ["T026"], "canonical_name": "Rad3-Rad26 complex"}
{"concept_id": "C2611011", "aliases": ["nucleosomal methylation activator complex location", "NUMAC"], "types": ["T026"], "canonical_name": "nucleosomal methylation activator complex", "definition": "A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription. [GOC:mah, PMID:14729568]"}
{"concept_id": "C2611012", "aliases": ["RAD52-ERCC4-ERCC1 complex location"], "types": ["T026"], "canonical_name": "RAD52-ERCC4-ERCC1 complex", "definition": "A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein. [PMID:14734547]"}
{"concept_id": "C2611013", "aliases": ["RGS6-DNMT1-DMAP1 complex location"], "types": ["T026"], "canonical_name": "RGS6-DNMT1-DMAP1 complex", "definition": "A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1. [GOC:mah, PMID:14734556]"}
{"concept_id": "C2611014", "aliases": ["stationary phase", "G1 to G0 transition", "G1/G0 transition"], "types": ["T043"], "definition": "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence. [GOC:mah, GOC:mtg_cell_cycle, ISBN:0815316194]", "canonical_name": "establishment of cell quiescence"}
{"concept_id": "C2611015", "aliases": ["cell cycle quiescence"], "types": ["T043"], "canonical_name": "cell cycle quiescence"}
{"concept_id": "C2611016", "aliases": ["G1/G0 transition involved in cell differentiation"], "types": ["T043"], "canonical_name": "G1 to G0 transition involved in cell differentiation", "definition": "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C2611017", "aliases": [], "types": ["T043"], "canonical_name": "regulation of G0 to G1 transition", "definition": "A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase. [GOC:mah]"}
{"concept_id": "C2611019", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of G0 to G1 transition", "definition": "A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase. [GOC:mah]"}
{"concept_id": "C2611020", "aliases": [], "types": ["T044"], "canonical_name": "inward rectifier potassium channel inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel. [GOC:mah]"}
{"concept_id": "C2611027", "aliases": [], "types": ["T044"], "canonical_name": "thyroid hormone binding", "definition": "Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. [GOC:rph]"}
{"concept_id": "C2611028", "aliases": [], "types": ["T044"], "canonical_name": "thyroxine binding"}
{"concept_id": "C2611029", "aliases": [], "types": ["T044"], "canonical_name": "triiodothyronine binding"}
{"concept_id": "C2611031", "aliases": ["very-low-density lipoprotein receptor binding", "VLDL receptor binding", "VLDLR binding"], "types": ["T044"], "canonical_name": "very-low-density lipoprotein particle receptor binding", "definition": "Binding to a very-low-density lipoprotein receptor. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2611032", "aliases": [], "types": ["T043"], "canonical_name": "thyroid hormone transport", "definition": "The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:rph]"}
{"concept_id": "C2611033", "aliases": [], "types": ["T043"], "canonical_name": "thyroxine transport"}
{"concept_id": "C2611034", "aliases": [], "types": ["T043"], "canonical_name": "triiodothyronine transport"}
{"concept_id": "C2611035", "aliases": ["triacylglycerol homeostasis"], "types": ["T039"], "canonical_name": "triglyceride homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2611036", "aliases": ["tRNA base modification to selenouridine"], "types": ["T044"], "canonical_name": "tRNA seleno-modification", "definition": "The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule. [GOC:jsg, PMID:14594807]"}
{"concept_id": "C2611037", "aliases": [], "types": ["T044"], "canonical_name": "estrogen synthetase activity"}
{"concept_id": "C2611038", "aliases": ["CD20-Lck-Fyn complex location"], "types": ["T026"], "canonical_name": "CD20-Lck-Fyn complex", "definition": "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn. [GOC:mah, PMID:7545683]"}
{"concept_id": "C2611039", "aliases": ["CD20-Lck-Lyn-Fyn complex location"], "types": ["T026"], "canonical_name": "CD20-Lck-Lyn-Fyn complex", "definition": "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn. [GOC:mah, PMID:7545683]"}
{"concept_id": "C2611040", "aliases": ["alpha6-beta4 integrin-Shc-Grb2 complex location"], "types": ["T026"], "canonical_name": "alpha6-beta4 integrin-Shc-Grb2 complex", "definition": "A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2. [PMID:7556090]"}
{"concept_id": "C2611041", "aliases": ["ITGA6-ITGB4-SHC-GRB2 complex location"], "types": ["T026"], "canonical_name": "ITGA6-ITGB4-SHC-GRB2 complex"}
{"concept_id": "C2611042", "aliases": ["alpha6-beta4 integrin-laminin-332 complex", "alpha6-beta4 integrin-laminin-332 complex location", "alpha6-beta4 integrin-laminin 5 complex location"], "types": ["T026"], "canonical_name": "alpha6-beta4 integrin-laminin 5 complex", "definition": "A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5. [GOC:mah, PMID:7556090]"}
{"concept_id": "C2611043", "aliases": ["ITGA6-ITGB4-LAMA5 complex location"], "types": ["T026"], "canonical_name": "ITGA6-ITGB4-LAMA5 complex"}
{"concept_id": "C2611044", "aliases": ["aspartic acid binding"], "types": ["T044"], "canonical_name": "aspartate binding", "definition": "Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4. [CHEBI:29995, GOC:mah]"}
{"concept_id": "C2611045", "aliases": [], "types": ["T045"], "canonical_name": "flap-structured DNA binding", "definition": "Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule. [GOC:mah, PMID:15189154]"}
{"concept_id": "C2611046", "aliases": [], "types": ["T045"], "canonical_name": "3'-flap-structured DNA binding", "definition": "Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule. [GOC:mah, PMID:15189154]"}
{"concept_id": "C2611047", "aliases": [], "types": ["T045"], "canonical_name": "5'-flap-structured DNA binding", "definition": "Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers. [GOC:mah, PMID:15189154]"}
{"concept_id": "C2611048", "aliases": [], "types": ["T040"], "canonical_name": "response to bacterial lipopeptide", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus. [GOC:add, PMID:12077222]"}
{"concept_id": "C2611049", "aliases": [], "types": ["T043"], "canonical_name": "detection of bacterial lipopeptide", "definition": "The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. [GOC:add, PMID:12077222]"}
{"concept_id": "C2611050", "aliases": ["adipose cell proliferation", "adipocyte proliferation"], "types": ["T043"], "canonical_name": "fat cell proliferation", "definition": "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611051", "aliases": ["brown adipose cell proliferation", "brown adipocyte proliferation"], "types": ["T043"], "canonical_name": "brown fat cell proliferation", "definition": "The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species. [CL:0000449, GOC:mah, GOC:sl]"}
{"concept_id": "C2611052", "aliases": ["white adipose cell proliferation", "white adipocyte proliferation"], "types": ["T043"], "canonical_name": "white fat cell proliferation", "definition": "The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population. [CL:0000448, GOC:mah, GOC:sl]"}
{"concept_id": "C2611053", "aliases": ["regulation of adipose cell proliferation", "regulation of adipocyte proliferation"], "types": ["T043"], "canonical_name": "regulation of fat cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of fat cell proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611054", "aliases": ["down regulation of fat cell proliferation", "negative regulation of adipocyte proliferation", "downregulation of fat cell proliferation", "negative regulation of adipose cell proliferation", "down-regulation of fat cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of fat cell proliferation", "definition": "Any process that stops or decreases the rate or extent of fat cell proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611055", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fat cell proliferation"}
{"concept_id": "C2611056", "aliases": ["positive regulation of adipose cell proliferation", "positive regulation of adipocyte proliferation", "up-regulation of fat cell proliferation", "upregulation of fat cell proliferation", "up regulation of fat cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of fat cell proliferation", "definition": "Any process that activates or increases the rate or extent of fat cell proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611057", "aliases": [], "types": ["T043"], "canonical_name": "activation of fat cell proliferation"}
{"concept_id": "C2611058", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of fat cell proliferation"}
{"concept_id": "C2611059", "aliases": ["regulation of brown adipose cell proliferation", "regulation of brown adipocyte proliferation"], "types": ["T043"], "canonical_name": "regulation of brown fat cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of brown fat cell proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611060", "aliases": ["down regulation of brown fat cell proliferation", "negative regulation of brown adipocyte proliferation", "downregulation of brown fat cell proliferation", "down-regulation of brown fat cell proliferation", "negative regulation of brown adipose cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of brown fat cell proliferation", "definition": "Any process that stops or decreases the rate or extent of brown fat cell proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611061", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of brown fat cell proliferation"}
{"concept_id": "C2611062", "aliases": ["upregulation of brown fat cell proliferation", "positive regulation of brown adipocyte proliferation", "up-regulation of brown fat cell proliferation", "positive regulation of brown adipose cell proliferation", "up regulation of brown fat cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of brown fat cell proliferation", "definition": "Any process that activates or increases the rate or extent of brown fat cell proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611063", "aliases": ["stimulation of brown fat cell proliferation"], "types": ["T043"], "canonical_name": "activation of brown fat cell proliferation"}
{"concept_id": "C2611064", "aliases": ["regulation of white adipose cell proliferation", "regulation of white adipocyte proliferation"], "types": ["T043"], "canonical_name": "regulation of white fat cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of white fat cell proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611065", "aliases": ["down regulation of white fat cell proliferation", "negative regulation of white adipose cell proliferation", "negative regulation of white adipocyte proliferation", "down-regulation of white fat cell proliferation", "downregulation of white fat cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of white fat cell proliferation", "definition": "Any process that stops or decreases the rate or extent of white fat cell proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611066", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of white fat cell proliferation"}
{"concept_id": "C2611067", "aliases": ["positive regulation of white adipose cell proliferation", "up regulation of white fat cell proliferation", "upregulation of white fat cell proliferation", "up-regulation of white fat cell proliferation", "positive regulation of white adipocyte proliferation"], "types": ["T043"], "canonical_name": "positive regulation of white fat cell proliferation", "definition": "Any process that activates or increases the rate or extent of white fat cell proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611068", "aliases": ["stimulation of white fat cell proliferation"], "types": ["T043"], "canonical_name": "activation of white fat cell proliferation"}
{"concept_id": "C2611069", "aliases": ["GATA1-TAL1-TCF3-Lmo2 complex location"], "types": ["T026"], "canonical_name": "GATA1-TAL1-TCF3-Lmo2 complex", "definition": "A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis. [PMID:7568177]"}
{"concept_id": "C2611070", "aliases": ["GATA2-TAL1-TCF3-Lmo2 complex location"], "types": ["T026"], "canonical_name": "GATA2-TAL1-TCF3-Lmo2 complex", "definition": "A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis. [PMID:7568177]"}
{"concept_id": "C2611072", "aliases": ["SNARE complex location (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)", "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex", "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)", "synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex location", "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex location"], "types": ["T026"], "canonical_name": "synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex", "definition": "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof). [PMID:7654227]"}
{"concept_id": "C2611075", "aliases": ["synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex location", "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex", "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)", "SNARE complex location (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)", "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex location"], "types": ["T026"], "canonical_name": "synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex", "definition": "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof). [PMID:7654227]"}
{"concept_id": "C2611077", "aliases": ["alphav-beta3 integrin-CD47 complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-CD47 complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP). [PMID:2277087, PMID:7691831]"}
{"concept_id": "C2611078", "aliases": ["ITGB3-ITGAV-CD47 complex location"], "types": ["T026"], "canonical_name": "ITGB3-ITGAV-CD47 complex"}
{"concept_id": "C2611079", "aliases": ["cell motility by actin tail formation"], "types": ["T043"], "canonical_name": "actin polymerization-dependent cell motility", "definition": "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell. [GOC:mah, PMID:15773977]"}
{"concept_id": "C2611081", "aliases": [], "types": ["T040"], "canonical_name": "migration of symbiont within host by polymerization of host actin"}
{"concept_id": "C2611086", "aliases": ["liver cell differentiation"], "types": ["T043"], "canonical_name": "hepatocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. [CL:0000182, PMID:7588884]"}
{"concept_id": "C2611087", "aliases": ["regulation of liver cell differentiation"], "types": ["T043"], "canonical_name": "regulation of hepatocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of hepatocyte differentiation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611088", "aliases": ["down-regulation of hepatocyte differentiation", "down regulation of hepatocyte differentiation", "negative regulation of liver cell differentiation", "downregulation of hepatocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of hepatocyte differentiation", "definition": "Any process that stops or decreases the rate or extent of hepatocyte differentiation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611089", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hepatocyte differentiation"}
{"concept_id": "C2611090", "aliases": ["up regulation of hepatocyte differentiation", "upregulation of hepatocyte differentiation", "positive regulation of liver cell differentiation", "up-regulation of hepatocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of hepatocyte differentiation", "definition": "Any process that activates or increases the rate or extent of hepatocyte differentiation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611091", "aliases": ["stimulation of hepatocyte differentiation"], "types": ["T043"], "canonical_name": "activation of hepatocyte differentiation"}
{"concept_id": "C2611092", "aliases": ["beta-catenin-TCF4 complex", "beta-catenin-TCF7L2 complex location", "beta-catenin-TCF4 complex location"], "types": ["T026"], "canonical_name": "beta-catenin-TCF7L2 complex", "definition": "A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. [GOC:BHF, GOC:rl, PMID:9065401, PMID:9065402]"}
{"concept_id": "C2611093", "aliases": ["cellular thermotolerance"], "types": ["T039"], "canonical_name": "cellular heat acclimation", "definition": "Any process that increases heat tolerance of a cell in response to high temperatures. [GOC:jp]"}
{"concept_id": "C2611094", "aliases": ["extracellular signal-regulated kinase 1/2 cascade", "ERK1 and ERK2 signaling pathway", "extracellular signal-regulated kinase 1/2 (ERK1/2) cascade", "ERK1/2 cascade", "ERK1 and ERK2 signalling pathway"], "types": ["T044"], "canonical_name": "ERK1 and ERK2 cascade", "definition": "An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [GOC:add, GOC:signaling, ISBN:0121245462, ISBN:0896039986, PMID:20811974, PMID:28903453]"}
{"concept_id": "C2611095", "aliases": [], "types": ["T044"], "canonical_name": "ERK cascade"}
{"concept_id": "C2611096", "aliases": [], "types": ["T044"], "canonical_name": "ERK1 cascade"}
{"concept_id": "C2611097", "aliases": [], "types": ["T044"], "canonical_name": "ERK2 cascade"}
{"concept_id": "C2611098", "aliases": [], "types": ["T044"], "canonical_name": "MAPK1 cascade"}
{"concept_id": "C2611099", "aliases": [], "types": ["T044"], "canonical_name": "MAPK3 cascade"}
{"concept_id": "C2611100", "aliases": ["regulation of ERK1/2 cascade", "regulation of ERK1 and ERK2 signaling pathway", "regulation of ERK1 and ERK2 signalling pathway"], "types": ["T044"], "canonical_name": "regulation of ERK1 and ERK2 cascade", "definition": "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]"}
{"concept_id": "C2611101", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ERK cascade"}
{"concept_id": "C2611102", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ERK1 cascade"}
{"concept_id": "C2611103", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ERK2 cascade"}
{"concept_id": "C2611104", "aliases": [], "types": ["T044"], "canonical_name": "regulation of MAPK1 cascade"}
{"concept_id": "C2611105", "aliases": [], "types": ["T044"], "canonical_name": "regulation of MAPK3 cascade"}
{"concept_id": "C2611106", "aliases": ["negative regulation of ERK1 and ERK2 signaling pathway", "downregulation of ERK1 and ERK2 cascade", "down-regulation of ERK1 and ERK2 cascade", "negative regulation of ERK1 and ERK2 signalling pathway", "down regulation of ERK1 and ERK2 cascade", "negative regulation of ERK1/2 cascade"], "types": ["T044"], "canonical_name": "negative regulation of ERK1 and ERK2 cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]"}
{"concept_id": "C2611107", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ERK1 and ERK2 cascade"}
{"concept_id": "C2611108", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ERK cascade"}
{"concept_id": "C2611109", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ERK1 cascade"}
{"concept_id": "C2611110", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ERK2 cascade"}
{"concept_id": "C2611111", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of MAPK1 cascade"}
{"concept_id": "C2611112", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of MAPK3 cascade"}
{"concept_id": "C2611113", "aliases": ["upregulation of ERK1 and ERK2 cascade", "positive regulation of ERK1 and ERK2 signalling pathway", "positive regulation of ERK1/2 cascade", "positive regulation of ERK1 and ERK2 signaling pathway", "up regulation of ERK1 and ERK2 cascade", "up-regulation of ERK1 and ERK2 cascade"], "types": ["T044"], "canonical_name": "positive regulation of ERK1 and ERK2 cascade", "definition": "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]"}
{"concept_id": "C2611114", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ERK cascade"}
{"concept_id": "C2611115", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ERK1 cascade"}
{"concept_id": "C2611116", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ERK2 cascade"}
{"concept_id": "C2611117", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of MAPK1 cascade"}
{"concept_id": "C2611118", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of MAPK3 cascade"}
{"concept_id": "C2611119", "aliases": ["stimulation of ERK1 and ERK2 cascade"], "types": ["T044"], "canonical_name": "activation of ERK1 and ERK2 cascade"}
{"concept_id": "C2611120", "aliases": ["MAPK7 cascade", "ERK5 signaling pathway", "BMK1 cascade", "BMK signalling pathway", "BMK cascade", "BMK signaling pathway", "big MAP kinase signaling cascade", "extracellular signal-regulated kinase 5 cascade"], "types": ["T044"], "canonical_name": "ERK5 cascade", "definition": "An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. [GOC:add, GOC:signaling, ISBN:0896039986, PMID:16376520, PMID:16880823, PMID:20811974, PMID:28903453]"}
{"concept_id": "C2611121", "aliases": ["regulation of ERK5 signaling pathway", "regulation of BMK1 cascade", "regulation of BMK cascade", "regulation of MAPK7 cascade", "regulation of BMK signaling pathway", "regulation of BMK signalling pathway"], "types": ["T044"], "canonical_name": "regulation of ERK5 cascade", "definition": "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]"}
{"concept_id": "C2611122", "aliases": ["negative regulation of MAPK7 cascade", "down-regulation of BMK cascade", "negative regulation of BMK1 cascade", "down regulation of BMK cascade", "negative regulation of BMK signalling pathway", "negative regulation of BMK signaling pathway", "downregulation of BMK cascade", "negative regulation of ERK5 signaling pathway", "negative regulation of BMK cascade"], "types": ["T044"], "canonical_name": "negative regulation of ERK5 cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]"}
{"concept_id": "C2611123", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of BMK cascade"}
{"concept_id": "C2611124", "aliases": ["upregulation of BMK cascade", "positive regulation of MAPK7 cascade", "positive regulation of BMK signaling pathway", "positive regulation of ERK5 signaling pathway", "up-regulation of BMK cascade", "positive regulation of BMK signalling pathway", "up regulation of BMK cascade", "positive regulation of BMK1 cascade", "positive regulation of BMK cascade"], "types": ["T044"], "canonical_name": "positive regulation of ERK5 cascade", "definition": "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade. [GOC:mah]"}
{"concept_id": "C2611125", "aliases": [], "types": ["T044"], "canonical_name": "activation of BMK cascade"}
{"concept_id": "C2611126", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of BMK cascade"}
{"concept_id": "C2611127", "aliases": ["HMGB1 binding"], "types": ["T044"], "canonical_name": "high mobility group box 1 binding", "definition": "Binding to high mobility group box 1 (HMBGB1). [GOC:add, PMID:18431461]"}
{"concept_id": "C2611128", "aliases": ["HMGB1 receptor activity"], "types": ["T044"], "canonical_name": "high mobility group box 1 receptor activity", "definition": "Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, PMID:18431461]"}
{"concept_id": "C2611129", "aliases": ["endosome-plasma membrane transport vesicle", "endosome to plasma membrane constitutive secretory pathway transport vesicle"], "types": ["T026"], "canonical_name": "endosome to plasma membrane transport vesicle", "definition": "A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis. [GOC:kad, GOC:mah, PMID:10679016, PMID:12110576]"}
{"concept_id": "C2611130", "aliases": ["exocytic constitutive secretory pathway transport vesicle", "exocytotic vesicle"], "types": ["T026"], "canonical_name": "exocytic vesicle", "definition": "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. [GOC:kad, GOC:mah]"}
{"concept_id": "C2611131", "aliases": [], "types": ["T045"], "canonical_name": "DNA cytosine deamination", "definition": "The removal of an amino group from a cytosine residue in DNA, forming a uracil residue. [GOC:mah]"}
{"concept_id": "C2611132", "aliases": [], "types": ["T042"], "canonical_name": "Harderian gland development", "definition": "The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species. [GOC:hjd, PMID:16856596, PMID:7559104]"}
{"concept_id": "C2611133", "aliases": ["egasyn-beta-glucuronidase complex location"], "types": ["T026"], "canonical_name": "egasyn-beta-glucuronidase complex", "definition": "A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum. [PMID:7744842]"}
{"concept_id": "C2611134", "aliases": ["procollagen-proline 4-dioxygenase complex location, alpha(I) type", "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex location, alpha(I) type", "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type"], "types": ["T026"], "canonical_name": "procollagen-proline 4-dioxygenase complex, alpha(I) type", "definition": "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline). [PMID:14500733, PMID:7753822]"}
{"concept_id": "C2611135", "aliases": ["prolyl 4-hydroxylase complex location (alpha(I)-type)"], "types": ["T026"], "canonical_name": "prolyl 4-hydroxylase complex (alpha(I)-type)"}
{"concept_id": "C2611136", "aliases": ["procollagen-proline, 2-oxoglutarate-4-dioxygenase complex location, alpha(II) type", "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type", "procollagen-proline 4-dioxygenase complex location, alpha(II) type"], "types": ["T026"], "canonical_name": "procollagen-proline 4-dioxygenase complex, alpha(II) type", "definition": "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations. [PMID:14500733, PMID:7753822]"}
{"concept_id": "C2611137", "aliases": ["prolyl 4-hydroxylase complex location (alpha(II)-type)"], "types": ["T026"], "canonical_name": "prolyl 4-hydroxylase complex (alpha(II)-type)"}
{"concept_id": "C2611138", "aliases": ["procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type", "procollagen-proline 4-dioxygenase complex location, alpha(III) type", "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex location, alpha(III) type"], "types": ["T026"], "canonical_name": "procollagen-proline 4-dioxygenase complex, alpha(III) type", "definition": "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform. [PMID:14500733]"}
{"concept_id": "C2611139", "aliases": ["prolyl 4-hydroxylase complex location (alpha(III)-type)"], "types": ["T026"], "canonical_name": "prolyl 4-hydroxylase complex (alpha(III)-type)"}
{"concept_id": "C2611141", "aliases": ["TREX-2 complex", "Sac3-Thp1-Sus1-Sem1-Cdc31 complex", "Sac3-Thp1-Sus1-Sem1-Cdc31 complex location", "TREX-2 complex location", "transcription export complex location 2"], "types": ["T026"], "canonical_name": "transcription export complex 2", "definition": "A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p. [GOC:dgf, GOC:mah, PMID:17786152, PMID:19289793, PMID:28334829]"}
{"concept_id": "C2611142", "aliases": ["response to LTA"], "types": ["T040"], "canonical_name": "response to lipoteichoic acid", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. [GOC:add, PMID:14665680, PMID:16020688]"}
{"concept_id": "C2611143", "aliases": ["detection of LTA"], "types": ["T043"], "canonical_name": "detection of lipoteichoic acid", "definition": "The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. [GOC:add, PMID:14665680, PMID:16020688]"}
{"concept_id": "C2611144", "aliases": ["teichoic acid breakdown", "teichoic acid degradation", "teichoic acid catabolism"], "types": ["T044"], "canonical_name": "teichoic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues. [GOC:add, PMID:14665680]"}
{"concept_id": "C2611145", "aliases": ["lipoteichoic acid metabolism", "LTA metabolic process"], "types": ["T044"], "canonical_name": "lipoteichoic acid metabolic process", "definition": "The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. [GOC:add, PMID:14665680, PMID:16020688]"}
{"concept_id": "C2611146", "aliases": ["lipoteichoic acid synthesis", "lipoteichoic acid biosynthetic process", "lipoteichoic acid anabolism", "LTA biosynthetic process", "lipoteichoic acid biosynthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. [GOC:add, PMID:14665680, PMID:16020688]", "canonical_name": "lipoteichoic acid formation"}
{"concept_id": "C2611147", "aliases": ["lipoteichoic acid breakdown", "lipoteichoic acid catabolism", "lipoteichoic acid degradation"], "types": ["T044"], "canonical_name": "lipoteichoic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. [GOC:add, PMID:14665680]"}
{"concept_id": "C2611148", "aliases": ["wall teichoic acid metabolism", "WTA metabolic process"], "types": ["T044"], "canonical_name": "wall teichoic acid metabolic process", "definition": "The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan. [GOC:add, PMID:14665680, PMID:16020688]"}
{"concept_id": "C2611149", "aliases": ["wall teichoic acid biosynthesis", "WTA biosynthetic process", "wall teichoic acid formation", "wall teichoic acid anabolism", "wall teichoic acid synthesis"], "types": ["T044"], "canonical_name": "wall teichoic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan. [GOC:add, PMID:14665680, PMID:16020688]"}
{"concept_id": "C2611150", "aliases": ["wall teichoic acid degradation", "wall teichoic acid catabolism", "wall teichoic acid breakdown"], "types": ["T044"], "canonical_name": "wall teichoic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan. [GOC:add, PMID:14665680]"}
{"concept_id": "C2611151", "aliases": ["teichoic acid alanylation"], "types": ["T044"], "canonical_name": "teichoic acid D-alanylation", "definition": "The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid. [GOC:add, PMID:14665680, PMID:16020688]"}
{"concept_id": "C2611152", "aliases": ["oxidized NADP binding", "oxidized nicotinamide adenine dinucleotide phosphate binding", "NADP+ binding"], "types": ["T044"], "definition": "Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]", "canonical_name": "NADP (oxidized) binding"}
{"concept_id": "C2611153", "aliases": ["reduced nicotinamide adenine dinucleotide phosphate binding", "reduced NADP binding", "NADP (reduced) binding"], "types": ["T044"], "canonical_name": "NADPH binding", "definition": "Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]"}
{"concept_id": "C2611154", "aliases": ["NAD+ binding", "NAD (oxidized) binding", "oxidized NAD binding"], "types": ["T044"], "definition": "Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]", "canonical_name": "oxidized nicotinamide adenine dinucleotide binding"}
{"concept_id": "C2611155", "aliases": ["reduced nicotinamide adenine dinucleotide binding", "NAD (reduced) binding", "reduced NAD binding"], "types": ["T044"], "canonical_name": "NADH binding", "definition": "Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]"}
{"concept_id": "C2611156", "aliases": ["ammonium binding"], "types": ["T044"], "canonical_name": "ammonium ion binding", "definition": "Binding to ammonium ions (NH4+). [CHEBI:28938, GOC:ecd]"}
{"concept_id": "C2611157", "aliases": [], "types": ["T044"], "canonical_name": "glutamine binding", "definition": "Binding to glutamine, 2,5-diamino-5-oxopentanoic acid. [CHEBI:28300, GOC:ecd]"}
{"concept_id": "C2611158", "aliases": ["oxidation-dependent protein degradation", "oxidation-dependent proteolysis", "oxidized protein catabolic process", "oxidation-dependent protein breakdown", "oxidation-dependent protein catabolism"], "types": ["T044"], "canonical_name": "oxidation-dependent protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein. [GOC:mah]"}
{"concept_id": "C2611159", "aliases": ["carbamoyl phosphate metabolism"], "types": ["T040"], "canonical_name": "carbamoyl phosphate metabolic process", "definition": "The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. [CHEBI:17672, GOC:mah, GOC:rph]"}
{"concept_id": "C2611160", "aliases": ["carbamoyl phosphate anabolism", "carbamoyl phosphate formation", "carbamyl phosphate biosynthetic process", "carbamoyl phosphate synthesis", "carbamoyl phosphate biosynthesis"], "types": ["T044"], "canonical_name": "carbamoyl phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. [CHEBI:17672, GOC:mah, GOC:rph]"}
{"concept_id": "C2611161", "aliases": ["common mediator SMAD binding", "common-partner SMAD binding", "common-mediator SMAD binding", "common partner SMAD binding"], "types": ["T044"], "canonical_name": "co-SMAD binding", "definition": "Binding to a common mediator SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]"}
{"concept_id": "C2611162", "aliases": [], "types": ["T044"], "canonical_name": "I-SMAD binding", "definition": "Binding to an inhibitory SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]"}
{"concept_id": "C2611163", "aliases": ["pathway-restricted SMAD binding", "pathway restricted SMAD binding", "receptor regulated SMAD binding", "receptor-regulated SMAD binding"], "types": ["T044"], "canonical_name": "R-SMAD binding", "definition": "Binding to a receptor-regulated SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]"}
{"concept_id": "C2611164", "aliases": ["trehalose metabolic process involved in response to stress"], "types": ["T044"], "canonical_name": "trehalose metabolism in response to stress", "definition": "The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress. [GOC:jp, GOC:mah, PMID:9797333]"}
{"concept_id": "C2611165", "aliases": ["trehalose metabolic process involved in response to heat stress"], "types": ["T039"], "canonical_name": "trehalose metabolism in response to heat stress", "definition": "The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:jp, GOC:mah, PMID:9797333]"}
{"concept_id": "C2611166", "aliases": ["trehalose metabolic process involved in response to cold stress"], "types": ["T044"], "canonical_name": "trehalose metabolism in response to cold stress", "definition": "The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:jp, GOC:mah, PMID:9797333]"}
{"concept_id": "C2611167", "aliases": ["trehalose metabolic process involved in response to water deprivation"], "types": ["T043"], "canonical_name": "trehalose metabolism in response to water deprivation", "definition": "The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water. [GOC:jp, GOC:mah, PMID:9797333]"}
{"concept_id": "C2611168", "aliases": ["cellular response to cold stress"], "types": ["T043"], "canonical_name": "cellular response to cold", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:jp]"}
{"concept_id": "C2611169", "aliases": ["DNA-dependent protein kinase, DNA-end-binding complex", "DNA-PK complex", "DNA-PK complex location", "DNA-dependent protein kinase complex location", "DNA-dependent protein kinase, DNA-end-binding complex location", "DNA-PK-Ku antigen complex location", "DNA-PK-Ku antigen complex"], "types": ["T026"], "canonical_name": "DNA-dependent protein kinase complex", "definition": "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku. [GOC:mah, PMID:10854421, PMID:12235392]"}
{"concept_id": "C2611171", "aliases": ["NHEJ complex", "non-homologous end joining complex location", "non-homologous end joining complex", "NHEJ complex location", "nonhomologous end joining complex location"], "types": ["T026"], "canonical_name": "nonhomologous end joining complex", "definition": "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends. [GOC:mah, PMID:17072889, PMID:17938628]"}
{"concept_id": "C2611172", "aliases": ["Ku-DNA ligase complex location"], "types": ["T026"], "canonical_name": "Ku-DNA ligase complex", "definition": "A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria. [GOC:mah, PMID:17938628]"}
{"concept_id": "C2611173", "aliases": ["DNA ligase III-XRCC1 complex location"], "types": ["T026"], "canonical_name": "DNA ligase III-XRCC1 complex", "definition": "A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair. [PMID:15141024, PMID:7760816]"}
{"concept_id": "C2611174", "aliases": ["G-protein beta/gamma-Raf-1 complex location"], "types": ["T026"], "canonical_name": "G-protein beta/gamma-Raf-1 complex", "definition": "A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein. [GOC:mah, PMID:7782277]"}
{"concept_id": "C2611175", "aliases": ["G protein complex location (GNG2, GNB2L1, RAF1)"], "types": ["T026"], "canonical_name": "G protein complex (GNG2, GNB2L1, RAF1)"}
{"concept_id": "C2611176", "aliases": ["nucleotide-binding oligomerization domain containing signalling pathway", "NOD signaling pathway"], "types": ["T044"], "canonical_name": "nucleotide-binding oligomerization domain containing signaling pathway", "definition": "The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing (NOD) protein receptor, and ending with regulation of a downstream cellular process. [GOC:add, PMID:17944960, PMID:18585455]"}
{"concept_id": "C2611177", "aliases": ["regulation of nucleotide-binding oligomerization domain containing signalling pathway", "regulation of NOD signaling pathway"], "types": ["T038"], "canonical_name": "regulation of nucleotide-binding oligomerization domain containing signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway. [GOC:add]"}
{"concept_id": "C2611178", "aliases": ["negative regulation of NOD signaling pathway", "negative regulation of nucleotide-binding oligomerization domain containing signalling pathway"], "types": ["T038"], "canonical_name": "negative regulation of nucleotide-binding oligomerization domain containing signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway. [GOC:add]"}
{"concept_id": "C2611179", "aliases": ["positive regulation of nucleotide-binding oligomerization domain containing signalling pathway", "positive regulation of NOD signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of nucleotide-binding oligomerization domain containing signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway. [GOC:add]"}
{"concept_id": "C2611180", "aliases": ["NOD1 signaling pathway", "nucleotide-binding oligomerization domain containing 1 signalling pathway"], "types": ["T044"], "canonical_name": "nucleotide-binding oligomerization domain containing 1 signaling pathway", "definition": "The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process. [GOC:add, PMID:17944960, PMID:18585455]"}
{"concept_id": "C2611181", "aliases": ["regulation of NOD1 signaling pathway", "regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway"], "types": ["T044"], "canonical_name": "regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway. [GOC:add]"}
{"concept_id": "C2611182", "aliases": ["negative regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway", "negative regulation of NOD1 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway. [GOC:add]"}
{"concept_id": "C2611183", "aliases": ["positive regulation of NOD1 signaling pathway", "positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway. [GOC:add]"}
{"concept_id": "C2611184", "aliases": ["NOD2 signaling pathway", "nucleotide-binding oligomerization domain containing 2 signalling pathway"], "types": ["T044"], "canonical_name": "nucleotide-binding oligomerization domain containing 2 signaling pathway", "definition": "The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process. [GOC:add, PMID:17944960, PMID:18585455]"}
{"concept_id": "C2611185", "aliases": ["regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway", "regulation of NOD2 signaling pathway"], "types": ["T044"], "canonical_name": "regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway", "definition": "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway. [GOC:add]"}
{"concept_id": "C2611186", "aliases": ["negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway", "negative regulation of NOD2 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway. [GOC:add]"}
{"concept_id": "C2611187", "aliases": ["positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway", "positive regulation of NOD2 signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway", "definition": "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway. [GOC:add]"}
{"concept_id": "C2611188", "aliases": ["Shc-EGFR complex location"], "types": ["T026"], "canonical_name": "Shc-EGFR complex", "definition": "A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway. [GOC:mah, PMID:7798267]"}
{"concept_id": "C2611189", "aliases": ["Shc-Egfr complex location, EGF stimulated"], "types": ["T026"], "canonical_name": "Shc-Egfr complex, EGF stimulated"}
{"concept_id": "C2611190", "aliases": ["Grb2-EGFR complex location"], "types": ["T026"], "definition": "A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway. [GOC:mah, PMID:7798267]", "canonical_name": "Grb2-EGFR complex"}
{"concept_id": "C2611191", "aliases": ["Grb2-Egfr complex location, EGF stimulated"], "types": ["T026"], "canonical_name": "Grb2-Egfr complex, EGF stimulated"}
{"concept_id": "C2611192", "aliases": ["Grb2-Shc complex location"], "types": ["T026"], "canonical_name": "Grb2-Shc complex", "definition": "A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway. [GOC:mah, PMID:7798267]"}
{"concept_id": "C2611193", "aliases": ["Grb2-Shc complex location, EGF stimulated"], "types": ["T026"], "canonical_name": "Grb2-Shc complex, EGF stimulated"}
{"concept_id": "C2611196", "aliases": ["Mad-Max-mSin3A complex location"], "types": ["T026"], "canonical_name": "Mad-Max-mSin3A complex", "definition": "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p. [PMID:7889570]"}
{"concept_id": "C2611197", "aliases": ["Mad-Max-mSin3B complex location"], "types": ["T026"], "canonical_name": "Mad-Max-mSin3B complex", "definition": "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p. [PMID:7889570]"}
{"concept_id": "C2611198", "aliases": ["G-protein beta/gamma-Btk complex location"], "types": ["T026"], "canonical_name": "G-protein beta/gamma-Btk complex", "definition": "A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein. [GOC:mah, PMID:7972043]"}
{"concept_id": "C2611199", "aliases": ["G protein complex location (BTK, GNG1, GNG2)"], "types": ["T026"], "canonical_name": "G protein complex (BTK, GNG1, GNG2)"}
{"concept_id": "C2611200", "aliases": ["G protein complex location (Btk, Gng2, Gnb1)"], "types": ["T026"], "canonical_name": "G protein complex (Btk, Gng2, Gnb1)"}
{"concept_id": "C2611201", "aliases": ["alphaIIb-beta3 integrin complex location", "alphaIIb-beta3 integrin complex", "integrin alphaIIb-beta3 complex location"], "types": ["T026"], "canonical_name": "integrin alphaIIb-beta3 complex", "definition": "An integrin complex that comprises one alphaIIb subunit and one beta3 subunit. [PMID:12297042]"}
{"concept_id": "C2611202", "aliases": ["ITGA2B-ITGB3 complex location"], "types": ["T026"], "canonical_name": "ITGA2B-ITGB3 complex"}
{"concept_id": "C2611203", "aliases": ["Mad-Max complex location"], "types": ["T026"], "canonical_name": "Mad-Max complex", "definition": "A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max. [PMID:8224841]"}
{"concept_id": "C2611204", "aliases": ["oligodendrocyte precursor proliferation"], "types": ["T043"], "canonical_name": "oligodendrocyte progenitor proliferation", "definition": "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system. [GOC:mah, GOC:sl, PMID:15504915]"}
{"concept_id": "C2611205", "aliases": ["regulation of oligodendrocyte precursor proliferation"], "types": ["T043"], "canonical_name": "regulation of oligodendrocyte progenitor proliferation", "definition": "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611206", "aliases": ["negative regulation of oligodendrocyte precursor proliferation"], "types": ["T043"], "canonical_name": "negative regulation of oligodendrocyte progenitor proliferation", "definition": "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611207", "aliases": ["positive regulation of oligodendrocyte precursor proliferation"], "types": ["T043"], "canonical_name": "positive regulation of oligodendrocyte progenitor proliferation", "definition": "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation. [GOC:mah, GOC:sl]"}
{"concept_id": "C2611208", "aliases": [], "types": ["T044"], "canonical_name": "laricitrin 5'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin. [RHEA:25633]"}
{"concept_id": "C2611209", "aliases": ["flavonoid 3',5'-O-dimethyltransferase activity"], "types": ["T044"], "canonical_name": "flavonoid 3',5'-O-dimethyltransferase activity"}
{"concept_id": "C2611210", "aliases": ["elongin (SIII) complex location", "transcription elongation factor SIII complex", "transcription factor B (SIII) complex", "elongin (SIII) complex", "elongin complex location", "transcription factor B (SIII) complex location", "transcription elongation factor SIII complex location"], "types": ["T026"], "definition": "A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits. [PMID:12676794]", "canonical_name": "elongin complex"}
{"concept_id": "C2611211", "aliases": ["IL4-IL4 receptor complex", "IL4-IL4 receptor complex location", "interleukin4-interleukin-4 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin4-interleukin-4 receptor complex", "definition": "A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule. [GOC:mah, PMID:10358772]"}
{"concept_id": "C2611212", "aliases": ["IL4-IL4R-IL2RG complex location"], "types": ["T026"], "canonical_name": "IL4-IL4R-IL2RG complex"}
{"concept_id": "C2611213", "aliases": [], "types": ["T026"], "canonical_name": "imaginal disc-derived wing hair"}
{"concept_id": "C2611214", "aliases": ["positive regulation of ergosterol biosynthesis", "up regulation of ergosterol biosynthetic process", "positive regulation of ergosterol anabolism", "positive regulation of ergosterol formation", "upregulation of ergosterol biosynthetic process", "up-regulation of ergosterol biosynthetic process", "positive regulation of ergosterol synthesis"], "types": ["T044"], "canonical_name": "positive regulation of ergosterol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol. [GOC:mah]"}
{"concept_id": "C2611215", "aliases": ["stimulation of ergosterol biosynthetic process"], "types": ["T044"], "canonical_name": "activation of ergosterol biosynthetic process"}
{"concept_id": "C2611216", "aliases": ["regulation of heme biosynthesis", "regulation of haem biosynthetic process", "regulation of haem biosynthesis", "regulation of heme anabolism", "regulation of heme synthesis", "regulation of heme formation"], "types": ["T044"], "canonical_name": "regulation of heme biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme. [GOC:mah]"}
{"concept_id": "C2611217", "aliases": ["down-regulation of heme biosynthetic process", "downregulation of heme biosynthetic process", "down regulation of heme biosynthetic process", "negative regulation of heme biosynthesis", "negative regulation of haem biosynthetic process", "negative regulation of heme synthesis", "negative regulation of heme formation", "negative regulation of heme anabolism"], "types": ["T044"], "canonical_name": "negative regulation of heme biosynthetic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme. [GOC:mah]"}
{"concept_id": "C2611218", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heme biosynthetic process"}
{"concept_id": "C2611219", "aliases": ["positive regulation of heme biosynthesis", "positive regulation of haem biosynthetic process", "positive regulation of heme synthesis", "upregulation of heme biosynthetic process", "positive regulation of heme formation", "up regulation of heme biosynthetic process", "up-regulation of heme biosynthetic process", "positive regulation of heme anabolism"], "types": ["T044"], "canonical_name": "positive regulation of heme biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme. [GOC:mah]"}
{"concept_id": "C2611220", "aliases": ["stimulation of heme biosynthetic process"], "types": ["T044"], "canonical_name": "activation of heme biosynthetic process"}
{"concept_id": "C2611221", "aliases": [], "types": ["T044"], "canonical_name": "galactose-1-phosphate phosphatase activity", "definition": "Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate. [GOC:mah]"}
{"concept_id": "C2611222", "aliases": [], "types": ["T044"], "canonical_name": "D-galactose-1-phosphate phosphatase activity", "definition": "Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate. [GOC:mah, PMID:9462881]"}
{"concept_id": "C2611223", "aliases": ["cellular detoxification of nitrogenous compound"], "types": ["T040"], "canonical_name": "cellular detoxification of nitrogen compound", "definition": "Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. [GOC:mah]"}
{"concept_id": "C2611224", "aliases": [], "types": ["T043"], "canonical_name": "prolactin secretion", "definition": "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2611225", "aliases": ["thyroid stimulating hormone secretion", "TSH secretion"], "types": ["T043"], "canonical_name": "thyroid-stimulating hormone secretion", "definition": "The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2611226", "aliases": ["SAGA family complex", "SAGA family complex location", "SAGA-type complex location"], "types": ["T026"], "canonical_name": "SAGA-type complex", "definition": "A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs). [GOC:mah, PMID:10637607, PMID:17337012]"}
{"concept_id": "C2611227", "aliases": [], "types": ["T043"], "canonical_name": "plus-end specific microtubule depolymerization", "definition": "The removal of tubulin heterodimers from the plus end of a microtubule. [GOC:krc, PMID:16906145, PMID:16906148]"}
{"concept_id": "C2611228", "aliases": ["tubulin-activated ATPase activity"], "types": ["T044"], "canonical_name": "tubulin-dependent ATPase activity", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate. [GOC:mah, PMID:16906148]"}
{"concept_id": "C2611229", "aliases": ["alphav-beta3 integrin-collagen alpha3(VI) complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-collagen alpha3(VI) complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen. [PMID:8387021]"}
{"concept_id": "C2611230", "aliases": ["alpha1-beta1 integrin-alpha3(VI) complex location"], "types": ["T026"], "canonical_name": "alpha1-beta1 integrin-alpha3(VI) complex", "definition": "A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain. [PMID:8387021]"}
{"concept_id": "C2611231", "aliases": ["ITGA1-ITGB1-COL6A3 complex location"], "types": ["T026"], "canonical_name": "ITGA1-ITGB1-COL6A3 complex"}
{"concept_id": "C2611232", "aliases": ["alpha2-beta1 integrin-alpha3(VI) complex location"], "types": ["T026"], "canonical_name": "alpha2-beta1 integrin-alpha3(VI) complex", "definition": "A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain. [PMID:8387021]"}
{"concept_id": "C2611233", "aliases": ["ITGA2-ITGB1-COL6A3 complex location"], "types": ["T026"], "canonical_name": "ITGA2-ITGB1-COL6A3 complex"}
{"concept_id": "C2611234", "aliases": ["RC-1 complex location (recombination complex 1)", "RC-1 complex (recombination complex 1)", "DNA recombination complex RC-1 location", "DNA recombination complex RC-1", "RC-1 DNA recombination complex location"], "types": ["T026"], "canonical_name": "RC-1 DNA recombination complex", "definition": "A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA. [PMID:8392064, PMID:8670910]"}
{"concept_id": "C2611235", "aliases": ["dentine secretion", "predentin secretion"], "types": ["T043"], "canonical_name": "dentin secretion"}
{"concept_id": "C2611236", "aliases": ["plasma membrane electron transport chain", "plasma membrane respiratory chain"], "types": ["T026"], "canonical_name": "plasma membrane respirasome", "definition": "A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. [GOC:curators, GOC:imk, GOC:mah, ISBN:0198547684]"}
{"concept_id": "C2611237", "aliases": ["regulation of myometrial contraction", "regulation of myometrium contraction", "regulation of myometrial smooth muscle contraction"], "types": ["T042"], "canonical_name": "regulation of uterine smooth muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction. [GOC:go_curators]"}
{"concept_id": "C2611238", "aliases": ["downregulation of uterine smooth muscle contraction", "down regulation of uterine smooth muscle contraction", "negative regulation of myometrial smooth muscle contraction", "negative regulation of myometrium contraction", "down-regulation of uterine smooth muscle contraction", "negative regulation of myometrial contraction"], "types": ["T040"], "canonical_name": "negative regulation of uterine smooth muscle contraction", "definition": "Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction. [GOC:go_curators]"}
{"concept_id": "C2611239", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of uterine smooth muscle contraction"}
{"concept_id": "C2611240", "aliases": ["uterine smooth muscle relaxation", "smooth muscle relaxation of the uterus"], "types": ["T042"], "canonical_name": "uterine smooth muscle relaxation", "definition": "A process in which the extent of smooth muscle contraction is reduced in the uterus. [GOC:jl]"}
{"concept_id": "C2611241", "aliases": ["upregulation of uterine smooth muscle contraction", "up-regulation of uterine smooth muscle contraction", "up regulation of uterine smooth muscle contraction", "positive regulation of myometrial contraction", "positive regulation of myometrial smooth muscle contraction", "positive regulation of myometrium contraction"], "types": ["T040"], "canonical_name": "positive regulation of uterine smooth muscle contraction", "definition": "Any process that increases the frequency, rate or extent of uterine smooth muscle contraction. [GOC:go_curators]"}
{"concept_id": "C2611242", "aliases": ["stimulation of uterine smooth muscle contraction"], "types": ["T040"], "canonical_name": "activation of uterine smooth muscle contraction"}
{"concept_id": "C2611243", "aliases": [], "types": ["T045"], "canonical_name": "rRNA base methylation", "definition": "The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. [GOC:mah]"}
{"concept_id": "C2611244", "aliases": [], "types": ["T045"], "canonical_name": "rRNA (guanine-N7)-methylation", "definition": "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule. [GOC:mah]"}
{"concept_id": "C2611245", "aliases": [], "types": ["T026"], "canonical_name": "endospore core", "definition": "An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive. [GOC:mah, PMID:15035041, PMID:18035610]"}
{"concept_id": "C2611246", "aliases": ["3'-5' nonsense-mediated mRNA decay", "3'-5' NMD", "nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay", "nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay", "nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay", "3'-5' nonsense-mediated decay"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay", "definition": "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. [PMID:12769863]"}
{"concept_id": "C2611247", "aliases": ["5'-3' nonsense-mediated mRNA decay", "nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay", "nuclear-transcribed mRNA degradation, 5'-3' exonucleolytic nonsense-mediated decay", "nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay", "5'-3' nonsense-mediated decay", "5'-3' NMD"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay", "definition": "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction. [PMID:18554525]"}
{"concept_id": "C2611248", "aliases": ["exonucleolytic nuclear-transcribed mRNA degradation involved in deadenylation-independent decay", "exonucleolytic nuclear-transcribed mRNA catabolism involved in deadenylation-independent decay", "exonucleolytic nuclear-transcribed mRNA breakdown involved in deadenylation-independent decay"], "types": ["T045"], "canonical_name": "exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay", "definition": "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs independent of deadenylation, but requires decapping followed by transcript decay. [GOC:jp]"}
{"concept_id": "C2611249", "aliases": [], "types": ["T043"], "canonical_name": "response to oxygen levels", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2611250", "aliases": ["detection of reduced oxygen levels"], "types": ["T043"], "canonical_name": "detection of hypoxia", "definition": "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2611251", "aliases": ["dehydro-D-arabinono-1,4-lactone metabolism"], "types": ["T044"], "canonical_name": "dehydro-D-arabinono-1,4-lactone metabolic process", "definition": "The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one. [GOC:cjk, GOC:mah]"}
{"concept_id": "C2611252", "aliases": ["dehydro-D-arabinono-1,4-lactone biosynthesis", "dehydro-D-arabinono-1,4-lactone synthesis", "dehydro-D-arabinono-1,4-lactone anabolism", "dehydro-D-arabinono-1,4-lactone formation"], "types": ["T044"], "canonical_name": "dehydro-D-arabinono-1,4-lactone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one. [GOC:cjk, GOC:mah]"}
{"concept_id": "C2611253", "aliases": ["leucocyte aggregation", "white blood cell aggregation", "white corpuscle aggregation", "immune cell aggregation"], "types": ["T043"], "canonical_name": "leukocyte aggregation", "definition": "The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules. [GOC:sl, PMID:12972508]"}
{"concept_id": "C2611254", "aliases": ["mononuclear phagocyte aggregation"], "types": ["T043"], "canonical_name": "monocyte aggregation", "definition": "The adhesion of one monocyte to one or more other monocytes via adhesion molecules. [GOC:sl, PMID:12972508]"}
{"concept_id": "C2611255", "aliases": ["neutrophil leukocyte aggregation", "neutrophilic leukocyte aggregation", "neutrocyte aggregation", "neutrophil leucocyte aggregation", "neutrophilic leucocyte aggregation"], "types": ["T043"], "canonical_name": "neutrophil aggregation", "definition": "The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules. [GOC:sl, PMID:12972508]"}
{"concept_id": "C2611256", "aliases": ["T-lymphocyte aggregation", "T lymphocyte aggregation", "T-cell aggregation"], "types": ["T043"], "canonical_name": "T cell aggregation", "definition": "The adhesion of one T cell to one or more other T cells via adhesion molecules. [GOC:sl, PMID:12972508]"}
{"concept_id": "C2611257", "aliases": ["pupylation", "Pup-protein conjugation"], "types": ["T044"], "canonical_name": "protein pupylation", "definition": "The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of Pup and the epsilon-amino group of a lysine residue of the target protein. [PMID:18980670]"}
{"concept_id": "C2611259", "aliases": [], "types": ["T044"], "canonical_name": "oligosaccharide binding", "definition": "Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [GOC:mah]"}
{"concept_id": "C2611260", "aliases": ["thrombin receptor signaling pathway", "thrombin receptor signalling pathway"], "types": ["T044"], "canonical_name": "thrombin-activated receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, PMID:1672265]"}
{"concept_id": "C2611261", "aliases": ["regulation of thrombin receptor signaling pathway", "regulation of thrombin receptor signalling pathway"], "types": ["T043"], "canonical_name": "regulation of thrombin-activated receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of a thrombin-activated receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands. [GOC:mah]"}
{"concept_id": "C2611262", "aliases": ["negative regulation of thrombin receptor signaling pathway", "negative regulation of thrombin receptor signalling pathway"], "types": ["T043"], "canonical_name": "negative regulation of thrombin-activated receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands. [GOC:mah]"}
{"concept_id": "C2611264", "aliases": ["positive regulation of thrombin receptor signalling pathway", "positive regulation of thrombin receptor signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of thrombin-activated receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands. [GOC:mah]"}
{"concept_id": "C2611265", "aliases": [], "types": ["T044"], "canonical_name": "6-carboxy-5,6,7,8-tetrahydropterin synthase activity", "definition": "Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+. [GOC:imk, MetaCyc:RXN0-5507, PMID:19231875]"}
{"concept_id": "C2611266", "aliases": ["interleukin-1-mediated signalling pathway", "IL-1-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-1-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah, GOC:signaling]"}
{"concept_id": "C2611267", "aliases": [], "types": ["T043"], "canonical_name": "IL-1 alpha-mediated signaling pathway"}
{"concept_id": "C2611268", "aliases": [], "types": ["T043"], "canonical_name": "IL-1 beta-mediated signaling pathway"}
{"concept_id": "C2611269", "aliases": [], "types": ["T043"], "canonical_name": "interleukin-1 alpha-mediated signaling pathway"}
{"concept_id": "C2611270", "aliases": [], "types": ["T043"], "canonical_name": "interleukin-1 beta-mediated signaling pathway"}
{"concept_id": "C2611271", "aliases": ["exosporium formation"], "types": ["T043"], "canonical_name": "exosporium assembly", "definition": "A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore. [GOC:mah]"}
{"concept_id": "C2611272", "aliases": ["poly-gamma-glutamate metabolism"], "types": ["T044"], "canonical_name": "poly-gamma-glutamate metabolic process", "definition": "The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds. [GOC:mah, PMID:16689787]"}
{"concept_id": "C2611273", "aliases": ["poly-gamma-glutamate anabolism", "poly-gamma-glutamate biosynthesis", "poly-gamma-glutamate synthesis", "poly-gamma-glutamate formation"], "types": ["T044"], "canonical_name": "poly-gamma-glutamate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds. [GOC:mah, PMID:16689787]"}
{"concept_id": "C2611274", "aliases": ["capsular poly-gamma-glutamate biosynthetic process", "capsule poly-gamma-glutamate synthesis", "capsule poly-gamma-glutamate formation", "capsule poly-gamma-glutamate biosynthesis", "capsule poly-gamma-glutamate anabolism"], "types": ["T043"], "canonical_name": "capsule poly-gamma-glutamate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule. [GOC:mah, PMID:16689787]"}
{"concept_id": "C2611275", "aliases": ["selenium-containing prosthetic group metabolism"], "types": ["T044"], "canonical_name": "selenium-containing prosthetic group metabolic process", "definition": "The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments. [GOC:dh, GOC:mah]"}
{"concept_id": "C2611276", "aliases": ["selenium-containing prosthetic group synthesis", "selenium-containing prosthetic group biosynthesis", "selenium-containing prosthetic group formation", "selenium-containing prosthetic group anabolism"], "types": ["T044"], "canonical_name": "selenium-containing prosthetic group biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments. [GOC:dh, GOC:mah]"}
{"concept_id": "C2611277", "aliases": ["high-density lipoprotein receptor activity", "HDL receptor"], "types": ["T044"], "definition": "Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis. [GOC:bf, GOC:BHF, GOC:rl, PMID:9211901]", "canonical_name": "high-density lipoprotein particle receptor activity"}
{"concept_id": "C2611278", "aliases": ["regulation of microtubule dynamics", "regulation of microtubule cytoskeleton organisation"], "types": ["T043"], "canonical_name": "regulation of microtubule cytoskeleton organization", "definition": "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah]"}
{"concept_id": "C2611279", "aliases": ["cholesterol uptake"], "types": ["T043"], "canonical_name": "cholesterol import", "definition": "The directed movement of cholesterol into a cell or organelle. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2611280", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H4-K20 methylation", "definition": "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4. [GOC:mah]"}
{"concept_id": "C2611281", "aliases": ["down regulation of histone H4-K20 methylation", "downregulation of histone H4-K20 methylation", "down-regulation of histone H4-K20 methylation"], "types": ["T044"], "canonical_name": "negative regulation of histone H4-K20 methylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4. [GOC:mah]"}
{"concept_id": "C2611282", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H4-K20 methylation"}
{"concept_id": "C2611283", "aliases": ["upregulation of histone H4-K20 methylation", "up regulation of histone H4-K20 methylation", "up-regulation of histone H4-K20 methylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H4-K20 methylation", "definition": "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4. [GOC:mah]"}
{"concept_id": "C2611284", "aliases": ["stimulation of histone H4-K20 methylation"], "types": ["T044"], "canonical_name": "activation of histone H4-K20 methylation"}
{"concept_id": "C2611285", "aliases": [], "types": ["T044"], "canonical_name": "death domain binding", "definition": "Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB. [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]"}
{"concept_id": "C2611286", "aliases": ["SRF-myogenin-E12 complex location"], "types": ["T026"], "canonical_name": "SRF-myogenin-E12 complex", "definition": "A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes. [PMID:8617811]"}
{"concept_id": "C2611287", "aliases": ["alphaIIb-beta3 integrin-talin complex location"], "types": ["T026"], "canonical_name": "alphaIIb-beta3 integrin-talin complex", "definition": "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin. [PMID:8663236]"}
{"concept_id": "C2611288", "aliases": ["ITGA2b-ITGB3-TLN1 complex location"], "types": ["T026"], "canonical_name": "ITGA2b-ITGB3-TLN1 complex"}
{"concept_id": "C2611289", "aliases": ["cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex location", "CAK-ERCC2 complex location", "cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex"], "types": ["T026"], "canonical_name": "CAK-ERCC2 complex", "definition": "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2. [PMID:8692841, PMID:8692842]"}
{"concept_id": "C2611290", "aliases": ["RFC core complex location", "DNA replication factor C core complex location", "RFC core complex"], "types": ["T026"], "canonical_name": "DNA replication factor C core complex", "definition": "A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37. [PMID:8692848, PMID:9228079, PMID:9582326]"}
{"concept_id": "C2611291", "aliases": ["alpha4-beta1 integrin-CD53 complex location"], "types": ["T026"], "canonical_name": "alpha4-beta1 integrin-CD53 complex", "definition": "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family. [PMID:8757325]"}
{"concept_id": "C2611292", "aliases": ["ITGA4-ITGB1-CD53 complex location"], "types": ["T026"], "canonical_name": "ITGA4-ITGB1-CD53 complex"}
{"concept_id": "C2611293", "aliases": ["alpha4-beta1 integrin-CD63 complex location"], "types": ["T026"], "canonical_name": "alpha4-beta1 integrin-CD63 complex", "definition": "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family. [PMID:8757325]"}
{"concept_id": "C2611294", "aliases": ["ITGA4-ITGB1-CD63 complex location"], "types": ["T026"], "canonical_name": "ITGA4-ITGB1-CD63 complex"}
{"concept_id": "C2611295", "aliases": ["alpha4-beta1 integrin-CD81 complex location"], "types": ["T026"], "canonical_name": "alpha4-beta1 integrin-CD81 complex", "definition": "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family. [PMID:10229664, PMID:8757325]"}
{"concept_id": "C2611296", "aliases": ["ITGA4-ITGB1-CD81 complex location"], "types": ["T026"], "canonical_name": "ITGA4-ITGB1-CD81 complex"}
{"concept_id": "C2611297", "aliases": ["alpha4-beta1 integrin-CD82 complex location"], "types": ["T026"], "canonical_name": "alpha4-beta1 integrin-CD82 complex", "definition": "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family. [PMID:8757325]"}
{"concept_id": "C2611298", "aliases": ["ERCC4-ERCC1 complex location", "XPF-ERCC1 complex location", "XPF-ERCC1 complex", "Rad1-Rad10 complex", "Rad1-Rad10 complex location"], "types": ["T026"], "canonical_name": "ERCC4-ERCC1 complex", "definition": "A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae. [PMID:14734547]"}
{"concept_id": "C2611299", "aliases": ["threonylcarbamoyladenosine metabolism", "t6A metabolism", "t6A metabolic process"], "types": ["T044"], "canonical_name": "tRNA threonylcarbamoyladenosine metabolic process", "definition": "The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. [GOC:imk, GOC:mah, PMID:19287007]"}
{"concept_id": "C2611301", "aliases": [], "types": ["T043"], "canonical_name": "thrombocyte aggregation"}
{"concept_id": "C2611302", "aliases": ["protein kinase C signal transduction", "PKC signaling cascade", "protein kinase C signalling cascade", "PKC signal transduction", "protein kinase C signaling cascade"], "types": ["T044"], "canonical_name": "protein kinase C signaling", "definition": "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2611303", "aliases": [], "types": ["T044"], "canonical_name": "K63-linked polyubiquitin modification-dependent protein binding", "definition": "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein. [GOC:mah, PMID:15556404, PMID:17525341]"}
{"concept_id": "C2611304", "aliases": ["BRCA1-A complex location"], "types": ["T026"], "canonical_name": "BRCA1-A complex", "definition": "A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. [GOC:mah, PMID:19261749]"}
{"concept_id": "C2611305", "aliases": ["BRCA1-B complex location"], "types": ["T026"], "canonical_name": "BRCA1-B complex", "definition": "A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites. [GOC:mah, PMID:16391231]"}
{"concept_id": "C2611306", "aliases": ["BRCA1-C complex location"], "types": ["T026"], "canonical_name": "BRCA1-C complex", "definition": "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint. [GOC:mah, PMID:15485915, PMID:16391231]"}
{"concept_id": "C2611307", "aliases": ["protein K63-linked polyubiquitination"], "types": ["T044"], "canonical_name": "protein K63-linked ubiquitination", "definition": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. [GOC:mah, PMID:15556404]"}
{"concept_id": "C2611308", "aliases": [], "types": ["T044"], "canonical_name": "histone H2A K63-linked ubiquitination", "definition": "A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX. [GOC:mah, PMID:18430235]"}
{"concept_id": "C2611309", "aliases": [], "types": ["T044"], "canonical_name": "protein K63-linked deubiquitination", "definition": "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. [GOC:mah, PMID:19202061, PMID:19214193]"}
{"concept_id": "C2611310", "aliases": [], "types": ["T044"], "canonical_name": "histone H2A K63-linked deubiquitination", "definition": "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX. [GOC:mah, PMID:19202061, PMID:19214193]"}
{"concept_id": "C2611311", "aliases": [], "types": ["T044"], "canonical_name": "oleic acid binding", "definition": "Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid. [GOC:lp, GOC:mah]"}
{"concept_id": "C2611312", "aliases": [], "types": ["T044"], "canonical_name": "linoleic acid binding", "definition": "Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid. [GOC:lp, GOC:mah]"}
{"concept_id": "C2611313", "aliases": [], "types": ["T044"], "canonical_name": "stearic acid binding", "definition": "Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid. [GOC:lp, GOC:mah]"}
{"concept_id": "C2611314", "aliases": ["response of symbiont to host osmotic environment"], "types": ["T043"], "canonical_name": "response to host osmotic environment", "definition": "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611315", "aliases": ["attachment of symbiont infection structure to host", "adhesion of symbiont infection structure to host during symbiotic interaction"], "types": ["T040"], "canonical_name": "adhesion of symbiont infection structure to host", "definition": "The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611316", "aliases": ["adhesion of symbiont germination tube to host during symbiotic interaction"], "types": ["T040"], "canonical_name": "adhesion of symbiont germination tube to host", "definition": "The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611317", "aliases": ["adhesion of symbiont appressorium to host during symbiotic interaction"], "types": ["T040"], "canonical_name": "adhesion of symbiont appressorium to host", "definition": "The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611318", "aliases": ["adhesion of symbiont spore to host during symbiotic interaction"], "types": ["T040"], "canonical_name": "adhesion of symbiont spore to host", "definition": "The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611323", "aliases": ["germ tube formation on or near host"], "types": ["T040"], "canonical_name": "germ tube formation", "definition": "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611324", "aliases": [], "types": ["T038"], "canonical_name": "regulation of germ tube formation", "definition": "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611325", "aliases": ["positive regulation of germ tube formation on or near host"], "types": ["T038"], "canonical_name": "positive regulation of germ tube formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611326", "aliases": ["negative regulation of germ tube formation on or near host"], "types": ["T038"], "canonical_name": "negative regulation of germ tube formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611329", "aliases": ["formation of infection structure on or near host"], "types": ["T040"], "canonical_name": "formation by symbiont of infection structure on or near host"}
{"concept_id": "C2611330", "aliases": ["formation of an appressorium by symbiont on or near host", "appressorium formation on or near host", "appressorium formation for entry into host, on or near host"], "types": ["T040"], "canonical_name": "appressorium formation", "definition": "The process in which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface. [GOC:pamgo_curators]"}
{"concept_id": "C2611331", "aliases": [], "types": ["T038"], "canonical_name": "regulation of appressorium formation on or near host"}
{"concept_id": "C2611332", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of appressorium formation on or near host"}
{"concept_id": "C2611333", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of appressorium formation on or near host"}
{"concept_id": "C2611339", "aliases": ["initiation of appressorium on or near host", "initiation of symbiont appressorium on or near host", "initiation of appressorium by symbiont on or near host", "appressorium initiation on or near host"], "types": ["T043"], "canonical_name": "initiation of appressorium formation", "definition": "The process in which a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611343", "aliases": ["formation of symbiont germ tube hook structure on or near host", "symbiont germ tube hook structure formation on or near host", "formation of germ tube tip of symbiont on or near the exterior of host", "formation of symbiont germ tube hook structure for appressorium development"], "types": ["T043"], "canonical_name": "formation of appressorium germ tube hook structure", "definition": "The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation. [GOC:pamgo_curators]"}
{"concept_id": "C2611344", "aliases": ["regulation of formation of symbiont germ tube hook structure on or near host", "modulation of germ tube tip of symbiont on or near the exterior of host", "modulation of symbiont germ tube hook structure formation on or near host"], "types": ["T038"], "canonical_name": "modulation of formation of symbiont germ tube hook structure for appressorium development", "definition": "Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation. [GOC:pamgo_curators]"}
{"concept_id": "C2611345", "aliases": ["positive regulation of symbiont germ tube hook structure formation on or near host", "positive regulation of germ tube tip of symbiont on or near the exterior of host", "positive regulation of formation of symbiont germ tube hook structure on or near host"], "types": ["T038"], "canonical_name": "positive regulation of formation of symbiont germ tube hook structure for appressorium development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation. [GOC:pamgo_curators]"}
{"concept_id": "C2611346", "aliases": ["negative regulation of formation of symbiont germ tube hook structure on or near host", "negative regulation of symbiont germ tube hook structure formation on or near host", "negative regulation of germ tube tip of symbiont on or near the exterior of host"], "types": ["T038"], "canonical_name": "negative regulation of formation of symbiont germ tube hook structure for appressorium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont germ tube hook structure formation. [GOC:pamgo_curators]"}
{"concept_id": "C2611349", "aliases": ["maturation of appressorium on or near host", "maturation of symbiont appressorium on or near host", "appressorium maturation on or near host"], "types": ["T043"], "canonical_name": "appressorium maturation", "definition": "The process in which specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611353", "aliases": ["generation of turgor in appressorium", "formation of turgor in appressorium", "establishment of turgor in symbiont appressorium on or near host"], "types": ["T043"], "canonical_name": "establishment of turgor in appressorium", "definition": "The process in which hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611358", "aliases": ["melanization of appressorium to maintain turgor pressure", "maintenance of turgor in appressorium by melanization"], "types": ["T044"], "canonical_name": "melanization of appressorium wall", "definition": "The process in which melanin is produced in the appressorium of the symbiont. Melanization of the appressorium increases turgor pressure in the appressorium. [GOC:pamgo_curators, PMID:28165657, Wikipedia:Appressorium]"}
{"concept_id": "C2611359", "aliases": [], "types": ["T043"], "canonical_name": "autophagy of host cells during interaction with symbiont"}
{"concept_id": "C2611360", "aliases": [], "types": ["T038"], "canonical_name": "regulation of formation by symbiont of haustorium for nutrient acquisition from host", "definition": "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611361", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of formation by symbiont of haustorium for nutrient acquisition from host", "definition": "Any process that activates or increases the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611362", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of formation by symbiont of haustorium for nutrient acquisition from host", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611368", "aliases": ["symbiont penetration peg formation for entry into host"], "types": ["T043"], "canonical_name": "formation of symbiont penetration peg for entry into host"}
{"concept_id": "C2611369", "aliases": [], "types": ["T038"], "canonical_name": "modulation of symbiont penetration peg formation for entry into host"}
{"concept_id": "C2611370", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of symbiont penetration peg formation for entry into host"}
{"concept_id": "C2611372", "aliases": ["symbiont penetration peg initiation"], "types": ["T043"], "canonical_name": "initiation of symbiont penetration peg"}
{"concept_id": "C2611373", "aliases": [], "types": ["T040"], "canonical_name": "modulation of symbiont penetration peg initiation"}
{"concept_id": "C2611374", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of symbiont penetration peg initiation"}
{"concept_id": "C2611384", "aliases": ["adhesion of symbiont infection cushion to host during symbiotic interaction"], "types": ["T044"], "canonical_name": "adhesion of symbiont infection cushion to host", "definition": "The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611385", "aliases": ["adhesion of symbiont hyphopodium to host during symbiotic interaction"], "types": ["T044"], "canonical_name": "adhesion of symbiont hyphopodium to host", "definition": "The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611386", "aliases": [], "types": ["T043"], "canonical_name": "autophagy during symbiotic interaction"}
{"concept_id": "C2611430", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host receptor-mediated signal transduction", "definition": "Any process in which the symbiont modulates the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611431", "aliases": ["positive regulation by symbiont of host receptor-mediated signal transduction"], "types": ["T040"], "canonical_name": "induction by symbiont of host receptor-mediated signal transduction", "definition": "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611432", "aliases": ["negative regulation by symbiont of host receptor-mediated signal transduction"], "types": ["T040"], "canonical_name": "suppression by symbiont of host receptor-mediated signal transduction", "definition": "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611433", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host transmembrane receptor-mediated signal transduction", "definition": "Any process in which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611434", "aliases": ["positive regulation by symbiont of host transmembrane receptor-mediated signal transduction"], "types": ["T040"], "canonical_name": "induction by symbiont of host transmembrane receptor-mediated signal transduction", "definition": "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611435", "aliases": ["negative regulation by symbiont of host transmembrane receptor-mediated signal transduction"], "types": ["T040"], "canonical_name": "suppression by symbiont of host transmembrane receptor-mediated signal transduction", "definition": "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611442", "aliases": ["modulation by symbiont of host G-protein coupled receptor protein signal transduction"], "types": ["T043"], "canonical_name": "modulation by symbiont of host G protein-coupled receptor signal transduction", "definition": "Any process in which the symbiont modulates the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611443", "aliases": ["positive regulation by symbiont of host G protein-coupled receptor signal transduction", "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction"], "types": ["T043"], "canonical_name": "induction by symbiont of host G protein-coupled receptor signal transduction", "definition": "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611444", "aliases": ["negative regulation by symbiont of host G protein-coupled receptor signal transduction", "negative regulation by symbiont of host G-protein coupled receptor protein signal transduction"], "types": ["T043"], "canonical_name": "suppression by symbiont of host G protein-coupled receptor signal transduction", "definition": "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611445", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host signal transduction mediated by G-protein alpha subunit"}
{"concept_id": "C2611446", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit"}
{"concept_id": "C2611447", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit"}
{"concept_id": "C2611448", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host signal transduction mediated by G-protein beta subunit"}
{"concept_id": "C2611450", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit"}
{"concept_id": "C2611451", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host signal transduction mediated by G-protein gamma subunit"}
{"concept_id": "C2611452", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit"}
{"concept_id": "C2611453", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit"}
{"concept_id": "C2611454", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host protein kinase-mediated signal transduction", "definition": "Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611455", "aliases": ["positive regulation by symbiont of host protein kinase-mediated signal transduction"], "types": ["T040"], "canonical_name": "induction by symbiont of host protein kinase-mediated signal transduction", "definition": "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611456", "aliases": ["negative regulation by symbiont of host protein kinase-mediated signal transduction"], "types": ["T040"], "canonical_name": "suppression by symbiont of host protein kinase-mediated signal transduction", "definition": "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611457", "aliases": ["modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction"], "types": ["T040"], "canonical_name": "modulation by symbiont of host calcium or calmodulin-mediated signal transduction", "definition": "Any process in which the symbiont modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611458", "aliases": ["positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction", "positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction"], "types": ["T040"], "canonical_name": "induction by symbiont of host calcium or calmodulin-mediated signal transduction", "definition": "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611459", "aliases": ["negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction", "negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction"], "types": ["T040"], "canonical_name": "suppression by symbiont of host calcium or calmodulin-mediated signal transduction", "definition": "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611460", "aliases": [], "types": ["T043"], "canonical_name": "response to host", "definition": "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611461", "aliases": [], "types": ["T040"], "canonical_name": "response of symbiont to host"}
{"concept_id": "C2611462", "aliases": ["response of symbiont to host redox environment"], "types": ["T040"], "canonical_name": "response to host redox environment", "definition": "Any process that results in a change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611463", "aliases": ["response of symbiont to host oxygen tension environment"], "types": ["T040"], "canonical_name": "response to host oxygen tension environment", "definition": "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611464", "aliases": ["response of symbiont to host iron concentration"], "types": ["T040"], "canonical_name": "response to host iron concentration", "definition": "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611465", "aliases": [], "types": ["T040"], "canonical_name": "response to host defense molecules"}
{"concept_id": "C2611470", "aliases": [], "types": ["T040"], "canonical_name": "maintenance of symbiont tolerance to host defense molecules"}
{"concept_id": "C2611508", "aliases": ["infection cushion formation on or near host"], "types": ["T040"], "canonical_name": "infection cushion formation", "definition": "The process in which an organized mass of hyphae is formed and numerous infective hyphae develop from the hyphae mass. [GOC:pamgo_curators]"}
{"concept_id": "C2611509", "aliases": ["regulation of infection cushion formation on or near host"], "types": ["T038"], "canonical_name": "regulation of infection cushion formation", "definition": "Any process that modulates the frequency, rate or extent of symbiont infection cushion formation. [GOC:pamgo_curators]"}
{"concept_id": "C2611510", "aliases": ["positive regulation of infection cushion formation on or near host"], "types": ["T038"], "canonical_name": "positive regulation of infection cushion formation", "definition": "Any process that activates or increases the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611511", "aliases": ["negative regulation of infection cushion formation on or near host"], "types": ["T038"], "canonical_name": "negative regulation of infection cushion formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611512", "aliases": ["hyphopodium formation on or near host"], "types": ["T043"], "canonical_name": "hyphopodium formation", "definition": "The process in which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611513", "aliases": ["regulation of hyphopodium formation on or near host"], "types": ["T038"], "canonical_name": "regulation of hyphopodium formation", "definition": "Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611514", "aliases": ["positive regulation of hyphopodium formation on or near host"], "types": ["T038"], "canonical_name": "positive regulation of hyphopodium formation", "definition": "Any process that activates or increases the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611515", "aliases": ["negative regulation of hyphopodium formation on or near host"], "types": ["T038"], "canonical_name": "negative regulation of hyphopodium formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611517", "aliases": ["haustorium mother cell formation on or near host"], "types": ["T043"], "canonical_name": "haustorium mother cell formation", "definition": "The process in which a symbiont cell is formed, separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611518", "aliases": ["regulation of haustorium mother cell formation on or near host"], "types": ["T038"], "canonical_name": "regulation of haustorium mother cell formation", "definition": "Any process that modulates the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611519", "aliases": ["positive regulation of haustorium mother cell formation on or near host"], "types": ["T038"], "canonical_name": "positive regulation of haustorium mother cell formation", "definition": "Any process that activates or increases the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611520", "aliases": ["negative regulation of haustorium mother cell formation on or near host"], "types": ["T038"], "canonical_name": "negative regulation of haustorium mother cell formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611521", "aliases": ["adhesion of symbiont haustorium mother cell to host during symbiotic interaction"], "types": ["T043"], "canonical_name": "adhesion of symbiont haustorium mother cell to host", "definition": "The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611522", "aliases": ["symbiont haustorium neck formation for entry into host"], "types": ["T043"], "canonical_name": "formation of symbiont haustorium neck for entry into host"}
{"concept_id": "C2611523", "aliases": [], "types": ["T038"], "canonical_name": "modulation of symbiont haustorium neck formation for entry into host", "definition": "Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611524", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of symbiont haustorium neck formation for entry into host", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611526", "aliases": ["symbiont penetration hypha formation for entry into host"], "types": ["T040"], "canonical_name": "formation of symbiont penetration hypha for entry into host"}
{"concept_id": "C2611527", "aliases": ["modulation of symbiont penetration hypha formation for entry into host"], "types": ["T038"], "canonical_name": "regulation of penetration hypha formation", "definition": "Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611528", "aliases": ["positive regulation of symbiont penetration hypha formation for entry into host"], "types": ["T038"], "canonical_name": "positive regulation of penetration hypha formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611534", "aliases": ["modulation by symbiont of host cAMP-mediated signaling"], "types": ["T040"], "canonical_name": "modulation by symbiont of host cAMP-mediated signal transduction", "definition": "Any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611535", "aliases": ["positive regulation by symbiont of host cAMP-mediated signaling", "positive regulation by symbiont of host cAMP-mediated signal transduction"], "types": ["T040"], "canonical_name": "induction by symbiont of host cAMP-mediated signal transduction", "definition": "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611536", "aliases": ["negative regulation by symbiont of host cAMP-mediated signal transduction", "negative regulation by symbiont of host cAMP-mediated signaling"], "types": ["T040"], "canonical_name": "suppression by symbiont of host cAMP-mediated signal transduction", "definition": "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611541", "aliases": [], "types": ["T040"], "canonical_name": "spore encystment on host"}
{"concept_id": "C2611542", "aliases": [], "types": ["T038"], "canonical_name": "modulation of spore encystment on host", "definition": "Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611543", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of spore encystment on host", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611544", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of spore encystment on host", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611545", "aliases": [], "types": ["T040"], "canonical_name": "zoospore encystment on host", "definition": "The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611546", "aliases": [], "types": ["T038"], "canonical_name": "modulation of zoospore encystment on host", "definition": "Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611547", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of zoospore encystment on host", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611548", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of zoospore encystment on host", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611549", "aliases": ["sporangium germination on or near host", "germination of symbiont sporangium on or near host", "symbiont sporangium germination on or near host"], "types": ["T038"], "canonical_name": "sporangium germination", "definition": "The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth. A sporangium is a structure producing and containing spores. [GOC:pamgo_curators]"}
{"concept_id": "C2611550", "aliases": [], "types": ["T038"], "canonical_name": "direct germination on or near host"}
{"concept_id": "C2611551", "aliases": [], "types": ["T038"], "canonical_name": "modulation of sporangium germination on or near host"}
{"concept_id": "C2611552", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of sporangium germination on or near host"}
{"concept_id": "C2611553", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of sporangium germination on or near host"}
{"concept_id": "C2611554", "aliases": ["encysted zoospore germination on or near host"], "types": ["T038"], "canonical_name": "encysted zoospore germination", "definition": "The physiological, developmental and morphological changes that occur in an encysted zoospore, that germinates by developing a germ tube that may penetrate the host directly or indirectly through an appressorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611555", "aliases": ["modulation of encysted zoospore germination on or near host"], "types": ["T038"], "canonical_name": "regulation of encysted zoospore germination", "definition": "Any process that modulates the frequency, rate or extent of an encysted zoospore germination. [GOC:pamgo_curators]"}
{"concept_id": "C2611556", "aliases": ["positive regulation of encysted zoospore germination on or near host"], "types": ["T038"], "canonical_name": "positive regulation of encysted zoospore germination", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of encysted zoospore germination. [GOC:pamgo_curators]"}
{"concept_id": "C2611557", "aliases": ["negative regulation of encysted zoospore germination on or near host"], "types": ["T038"], "canonical_name": "negative regulation of encysted zoospore germination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of encysted zoospore germination. [GOC:pamgo_curators]"}
{"concept_id": "C2611567", "aliases": [], "types": ["T043"], "canonical_name": "zoospore formation", "definition": "The process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. [GOC:pamgo_curators]"}
{"concept_id": "C2611568", "aliases": [], "types": ["T043"], "canonical_name": "regulation of zoospore formation", "definition": "Any process that modulates the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. [GOC:pamgo_curators]"}
{"concept_id": "C2611569", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of zoospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. [GOC:pamgo_curators]"}
{"concept_id": "C2611570", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of zoospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. [GOC:pamgo_curators]"}
{"concept_id": "C2611571", "aliases": [], "types": ["T043"], "canonical_name": "oospore formation", "definition": "The process in which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of Oomycetes and certain algae and fungi. [GOC:pamgo_curators]"}
{"concept_id": "C2611572", "aliases": [], "types": ["T043"], "canonical_name": "regulation of oospore formation", "definition": "Any process that modulates the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes. [GOC:pamgo_curators]"}
{"concept_id": "C2611573", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of oospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes. [GOC:pamgo_curators]"}
{"concept_id": "C2611574", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of oospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes. [GOC:pamgo_curators]"}
{"concept_id": "C2611575", "aliases": [], "types": ["T043"], "canonical_name": "aeciospore formation", "definition": "The process in which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host. [GOC:pamgo_curators]"}
{"concept_id": "C2611576", "aliases": [], "types": ["T043"], "canonical_name": "regulation of aeciospore formation", "definition": "Any process that modulates the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium. [GOC:pamgo_curators]"}
{"concept_id": "C2611577", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of aeciospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium. [GOC:pamgo_curators]"}
{"concept_id": "C2611578", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of aeciospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium. [GOC:pamgo_curators]"}
{"concept_id": "C2611579", "aliases": ["ureidospore formation", "urediniospore formation"], "types": ["T043"], "canonical_name": "uredospore formation", "definition": "The process which specific outcome is the formation of an asexual, dikaryotic, often rusty-colored spore, produced in a structure called a uredinium; mostly found in the rust fungus. [GOC:pamgo_curators]"}
{"concept_id": "C2611580", "aliases": ["regulation of ureidospore formation"], "types": ["T043"], "canonical_name": "regulation of uredospore formation", "definition": "Any process that modulates the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium. [GOC:pamgo_curators]"}
{"concept_id": "C2611581", "aliases": ["positive regulation of ureidospore formation"], "types": ["T043"], "canonical_name": "positive regulation of uredospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium. [GOC:pamgo_curators]"}
{"concept_id": "C2611582", "aliases": ["negative regulation of ureidospore formation"], "types": ["T043"], "canonical_name": "negative regulation of uredospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium. [GOC:pamgo_curators]"}
{"concept_id": "C2611583", "aliases": [], "types": ["T043"], "canonical_name": "teliospore formation", "definition": "The set of processes leading to the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs. [GOC:pamgo_curators]"}
{"concept_id": "C2611584", "aliases": [], "types": ["T043"], "canonical_name": "regulation of teliospore formation", "definition": "Any process that modulates the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs. [GOC:pamgo_curators]"}
{"concept_id": "C2611585", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of teliospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs. [GOC:pamgo_curators]"}
{"concept_id": "C2611586", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of teliospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs. [GOC:pamgo_curators]"}
{"concept_id": "C2611587", "aliases": ["spore-bearing organ development", "sporophore development", "fruiting structure development"], "types": ["T043"], "canonical_name": "spore-bearing structure development", "definition": "The process whose specific outcome is the progression of a spore-bearing structure over time, from its formation to the mature structure. A spore-bearing structure is an anatomical structure that produces new spores. [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators]"}
{"concept_id": "C2611588", "aliases": [], "types": ["T043"], "canonical_name": "regulation of spore-bearing organ development", "definition": "Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores. [GOC:pamgo_curators]"}
{"concept_id": "C2611589", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of spore-bearing organ development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores. [GOC:pamgo_curators]"}
{"concept_id": "C2611590", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of spore-bearing organ development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores. [GOC:pamgo_curators]"}
{"concept_id": "C2611591", "aliases": [], "types": ["T038"], "canonical_name": "oogonium development", "definition": "The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes. [GOC:pamgo_curators]"}
{"concept_id": "C2611592", "aliases": [], "types": ["T038"], "canonical_name": "regulation of oogonium development", "definition": "Any process that modulates the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes. [GOC:pamgo_curators]"}
{"concept_id": "C2611593", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of oogonium development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes. [GOC:pamgo_curators]"}
{"concept_id": "C2611594", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of oogonium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes. [GOC:pamgo_curators]"}
{"concept_id": "C2611595", "aliases": [], "types": ["T038"], "canonical_name": "aecium development", "definition": "The process in which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium. [GOC:pamgo_curators]"}
{"concept_id": "C2611596", "aliases": [], "types": ["T038"], "canonical_name": "regulation of aecium development", "definition": "Any process that modulates the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed. [GOC:pamgo_curators]"}
{"concept_id": "C2611597", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of aecium development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed. [GOC:pamgo_curators]"}
{"concept_id": "C2611598", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of aecium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed. [GOC:pamgo_curators]"}
{"concept_id": "C2611599", "aliases": [], "types": ["T038"], "canonical_name": "zygosporangium development", "definition": "The process in which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes. [GOC:pamgo_curators]"}
{"concept_id": "C2611600", "aliases": [], "types": ["T038"], "canonical_name": "regulation of zygosporangium development", "definition": "Any process that modulates the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed. [GOC:pamgo_curators]"}
{"concept_id": "C2611601", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of zygosporangium development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed. [GOC:pamgo_curators]"}
{"concept_id": "C2611602", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of zygosporangium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed. [GOC:pamgo_curators]"}
{"concept_id": "C2611603", "aliases": [], "types": ["T038"], "canonical_name": "telium development", "definition": "The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi. [GOC:pamgo_curators]"}
{"concept_id": "C2611604", "aliases": [], "types": ["T038"], "canonical_name": "regulation of telium development", "definition": "Any process that modulates the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi. [GOC:pamgo_curators]"}
{"concept_id": "C2611605", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of telium development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi. [GOC:pamgo_curators]"}
{"concept_id": "C2611606", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of telium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi. [GOC:pamgo_curators]"}
{"concept_id": "C2611607", "aliases": ["development of uredium"], "types": ["T038"], "canonical_name": "uredinium development", "definition": "The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores. [GOC:pamgo_curators]"}
{"concept_id": "C2611608", "aliases": [], "types": ["T038"], "canonical_name": "regulation of uredinium development", "definition": "Any process that modulates the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores. [GOC:pamgo_curators]"}
{"concept_id": "C2611609", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of uredinium development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores. [GOC:pamgo_curators]"}
{"concept_id": "C2611610", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of uredinium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores. [GOC:pamgo_curators]"}
{"concept_id": "C2611611", "aliases": ["multicellular or syncytial spore formation by sporulation"], "types": ["T043"], "canonical_name": "sporulation resulting in formation of a multicellular or syncytial spore", "definition": "The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure. [GOC:pamgo_curators]"}
{"concept_id": "C2611612", "aliases": [], "types": ["T043"], "canonical_name": "asexual sporulation resulting in formation of a multicellular or syncytial spore", "definition": "The formation of a multicellular or syncytial spore via septations derived from mitosis. [GOC:pamgo_curators]"}
{"concept_id": "C2611613", "aliases": [], "types": ["T043"], "canonical_name": "sexual sporulation resulting in formation of a multicellular or syncytial spore", "definition": "The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. [GOC:pamgo_curators]"}
{"concept_id": "C2611614", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sporangiospore formation", "definition": "Any process that modulates the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. [GOC:pamgo_curators]"}
{"concept_id": "C2611615", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of sporangiospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. [GOC:pamgo_curators]"}
{"concept_id": "C2611616", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of sporangiospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. [GOC:pamgo_curators]"}
{"concept_id": "C2611617", "aliases": [], "types": ["T043"], "canonical_name": "aplanospore formation", "definition": "The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. [GOC:pamgo_curators]"}
{"concept_id": "C2611618", "aliases": [], "types": ["T043"], "canonical_name": "regulation of aplanospore formation", "definition": "Any process that modulates the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. [GOC:pamgo_curators]"}
{"concept_id": "C2611619", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of aplanospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. [GOC:pamgo_curators]"}
{"concept_id": "C2611620", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of aplanospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. [GOC:pamgo_curators]"}
{"concept_id": "C2611621", "aliases": ["response of symbiont to host pH environment"], "types": ["T040"], "canonical_name": "response to host pH environment", "definition": "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611622", "aliases": ["up regulation by symbiont of entry into host", "upregulation by symbiont of entry into host", "up-regulation by symbiont of entry into host"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of entry into host", "definition": "Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611623", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of entry into host"}
{"concept_id": "C2611625", "aliases": [], "types": ["T040"], "canonical_name": "activation by organism of entry into other organism during symbiotic interaction"}
{"concept_id": "C2611626", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ascospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus. [GOC:pamgo_curators]"}
{"concept_id": "C2611627", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ascospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus. [GOC:pamgo_curators]"}
{"concept_id": "C2611628", "aliases": [], "types": ["T043"], "canonical_name": "regulation of zygospore formation", "definition": "Any process that modulates the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase. [GOC:pamgo_curators]"}
{"concept_id": "C2611629", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of zygospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase. [GOC:pamgo_curators]"}
{"concept_id": "C2611630", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of zygospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase. [GOC:pamgo_curators]"}
{"concept_id": "C2611632", "aliases": [], "types": ["T043"], "canonical_name": "regulation of basidiospore formation", "definition": "Any process that modulates the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes. [GOC:pamgo_curators]"}
{"concept_id": "C2611633", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of basidiospore formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes. [GOC:pamgo_curators]"}
{"concept_id": "C2611634", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of basidiospore formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes. [GOC:pamgo_curators]"}
{"concept_id": "C2611636", "aliases": [], "types": ["T038"], "canonical_name": "regulation of conidium formation", "definition": "Any process that modulates the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. [GOC:di, GOC:pamgo_curators]"}
{"concept_id": "C2611637", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of conidium formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. [GOC:di, GOC:pamgo_curators]"}
{"concept_id": "C2611638", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of conidium formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. [GOC:di, GOC:pamgo_curators]"}
{"concept_id": "C2611640", "aliases": [], "types": ["T038"], "canonical_name": "regulation of sporangium development", "definition": "Any process that modulates the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms. [GOC:pamgo_curators]"}
{"concept_id": "C2611641", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of sporangium development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms. [GOC:pamgo_curators]"}
{"concept_id": "C2611642", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of sporangium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms. [GOC:pamgo_curators]"}
{"concept_id": "C2611643", "aliases": [], "types": ["T038"], "canonical_name": "basidium development", "definition": "The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi. [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators]"}
{"concept_id": "C2611644", "aliases": [], "types": ["T038"], "canonical_name": "regulation of basidium development", "definition": "Any process that modulates the frequency, rate or extent of basidium development, a process that leads to the formation of a basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi. [GOC:pamgo_curators]"}
{"concept_id": "C2611645", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of basidium development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi. [GOC:pamgo_curators]"}
{"concept_id": "C2611646", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of basidium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi. [GOC:pamgo_curators]"}
{"concept_id": "C2611647", "aliases": [], "types": ["T038"], "definition": "Any process that modulates the frequency, rate or extent of ascus development, a process that leads to the formation of basidium, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed. [GOC:pamgo_curators]", "canonical_name": "regulation of ascus development"}
{"concept_id": "C2611648", "aliases": ["positive regulation of ascus development"], "types": ["T043"], "canonical_name": "positive regulation of ascus development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed. [GOC:pamgo_curators]"}
{"concept_id": "C2611649", "aliases": ["negative regulation of ascus development"], "types": ["T038"], "canonical_name": "negative regulation of ascus development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed. [GOC:pamgo_curators]"}
{"concept_id": "C2611650", "aliases": [], "types": ["T043"], "canonical_name": "oomycete sporangium development", "definition": "The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated. [GOC:pamgo_curators]"}
{"concept_id": "C2611651", "aliases": [], "types": ["T038"], "canonical_name": "regulation of oomycete sporangium development", "definition": "Any process that modulates the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated. [GOC:pamgo_curators]"}
{"concept_id": "C2611652", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of oomycete sporangium development", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated. [GOC:pamgo_curators]"}
{"concept_id": "C2611653", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of oomycete sporangium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated. [GOC:pamgo_curators]"}
{"concept_id": "C2611654", "aliases": ["spore dispersal on or near host", "spore dispersal on or near host during symbiotic interaction"], "types": ["T043"], "canonical_name": "spore dispersal", "definition": "Any process in which an organism disseminates its spores. [Wikipedia:Spore]"}
{"concept_id": "C2611656", "aliases": [], "types": ["T040"], "canonical_name": "passive spore dispersal on or near host"}
{"concept_id": "C2611657", "aliases": [], "types": ["T043"], "canonical_name": "formation by symbiont of arbuscule for nutrient acquisition from host"}
{"concept_id": "C2611658", "aliases": [], "types": ["T038"], "canonical_name": "regulation of arbuscule formation for nutrient acquisition from host", "definition": "Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611659", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of arbuscule formation for nutrient acquisition from host", "definition": "Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611660", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of arbuscule formation for nutrient acquisition from host", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611670", "aliases": ["host cell PML nuclear body", "host cell PML NB"], "types": ["T026"], "canonical_name": "host cell PML body", "definition": "A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism. [GOC:BHF, GOC:jl]"}
{"concept_id": "C2611671", "aliases": ["disassembly by symbiont of host cell PML nuclear body", "disassembly by symbiont of host cell PML NB", "catabolism by symbiont of host cell PML body", "disassembly by symbiont of host cell PML body during symbiotic interaction", "disassembly by symbiont of host cell PML body", "degradation by symbiont of host cell PML body"], "types": ["T040"], "canonical_name": "disruption by symbiont of host cell PML body", "definition": "The breakdown, by the symbiont, of a PML body within a host cell. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:BHF, GOC:jl]"}
{"concept_id": "C2611672", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of abscisic acid levels in host", "definition": "The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2611676", "aliases": [], "types": ["T039"], "canonical_name": "mucilage extrusion from seed coat", "definition": "The process in which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat. [PMID:18266922]"}
{"concept_id": "C2611677", "aliases": [], "types": ["T039"], "canonical_name": "mucilage release from seed coat"}
{"concept_id": "C2611678", "aliases": [], "types": ["T039"], "canonical_name": "secretion of mucilage from seed coat"}
{"concept_id": "C2611679", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:4-aminobenzoate acylglucosyltransferase activity", "definition": "Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP. [EC:2.4.1.-, PMID:18385129]"}
{"concept_id": "C2611680", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:p-aminobenzoate acylglucosyltransferase activity"}
{"concept_id": "C2611681", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:p-aminobenzoate glucosyltransferase activity"}
{"concept_id": "C2611682", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:pABA acylglucosyltransferase activity"}
{"concept_id": "C2611683", "aliases": ["thalianol metabolism"], "types": ["T044"], "canonical_name": "thalianol metabolic process", "definition": "The chemical reactions and pathways involving the triterpene thalianol. [PMID:18356490]"}
{"concept_id": "C2611684", "aliases": [], "types": ["T044"], "canonical_name": "thalian-diol desaturase activity", "definition": "Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15. [PMID:18356490]"}
{"concept_id": "C2611685", "aliases": [], "types": ["T039"], "canonical_name": "photosystem stoichiometry adjustment", "definition": "Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis. [PMID:11607105]"}
{"concept_id": "C2611686", "aliases": [], "types": ["T040"], "canonical_name": "internode patterning", "definition": "Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached. [GOC:tb]"}
{"concept_id": "C2611687", "aliases": [], "types": ["T044"], "canonical_name": "S-nitrosoglutathione reductase activity", "definition": "Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+. [MetaCyc:RXN-10742, PMID:11260719]"}
{"concept_id": "C2611688", "aliases": ["Cul4-RING E3 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "Cul4-RING E3 ubiquitin ligase complex", "definition": "A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. [PMID:16792691, PMID:18223036, PMID:18552200]"}
{"concept_id": "C2611689", "aliases": [], "types": ["T045"], "canonical_name": "mRNA methylation", "definition": "The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule. [PMID:18505803]"}
{"concept_id": "C2611691", "aliases": [], "types": ["T044"], "canonical_name": "baruol synthase activity", "definition": "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol. [PMID:17705488, RHEA:31987]"}
{"concept_id": "C2611692", "aliases": ["N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity"], "types": ["T044"], "canonical_name": "trihydroxyferuloyl spermidine O-methyltransferase activity", "definition": "Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+. [PMID:18557837]"}
{"concept_id": "C2611693", "aliases": [], "types": ["T044"], "canonical_name": "(E,E)-geranyllinalool synthase activity", "definition": "Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate. [MetaCyc:RXN-10441, PMID:18398052]"}
{"concept_id": "C2611694", "aliases": [], "types": ["T044"], "canonical_name": "thalianol hydroxylase activity", "definition": "Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X. [MetaCyc:RXN-9631, PMID:17474751, PMID:18356490]"}
{"concept_id": "C2611695", "aliases": [], "types": ["T044"], "canonical_name": "sabinene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate. [MetaCyc:RXN-5103, PMID:12566586, PMID:9747540]"}
{"concept_id": "C2611696", "aliases": [], "types": ["T044"], "canonical_name": "(-)-E-beta-caryophyllene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate. [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047]"}
{"concept_id": "C2611697", "aliases": [], "types": ["T044"], "canonical_name": "alpha-humulene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate. [PMID:12566586, PMID:9442047, RHEA:31895]"}
{"concept_id": "C2611698", "aliases": [], "types": ["T044"], "canonical_name": "anthocyanin 5-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP. [PMID:15807784]"}
{"concept_id": "C2611699", "aliases": ["fatty acyl-CoA reductase (alcohol-forming) activity", "fatty acyl CoA reductase (alcohol-forming) activity"], "types": ["T044"], "canonical_name": "fatty-acyl-CoA reductase (alcohol-forming) activity", "definition": "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. [PMID:16980563]"}
{"concept_id": "C2611700", "aliases": [], "types": ["T044"], "canonical_name": "regulation of coenzyme A biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A. [PMID:18621975]"}
{"concept_id": "C2611701", "aliases": ["response to benzoic acid stimulus"], "types": ["T043"], "canonical_name": "response to benzoic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus. [PMID:18753285]"}
{"concept_id": "C2611702", "aliases": [], "types": ["T040"], "canonical_name": "primary root development", "definition": "The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle. [GOC:dhl]"}
{"concept_id": "C2611703", "aliases": [], "types": ["T044"], "canonical_name": "3R-hydroxyacyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O. [PMID:16982622]"}
{"concept_id": "C2611704", "aliases": ["IBA metabolism", "IBA metabolic process"], "types": ["T044"], "canonical_name": "indolebutyric acid metabolic process", "definition": "The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants. [PMID:18725356]"}
{"concept_id": "C2611705", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-butyric acid metabolic process"}
{"concept_id": "C2611706", "aliases": ["PtdIns(3,5)P2 binding"], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,5-bisphosphate binding", "definition": "Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. [GOC:bf, PMID:18397324]"}
{"concept_id": "C2611707", "aliases": ["response to IBA stimulus", "response to indolebutyric acid stimulus"], "types": ["T043"], "canonical_name": "response to indolebutyric acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus. [PMID:18725356]"}
{"concept_id": "C2611708", "aliases": [], "types": ["T043"], "canonical_name": "response to indole-3-butyric acid stimulus"}
{"concept_id": "C2611709", "aliases": [], "types": ["T040"], "canonical_name": "response to herbivore", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore. [PMID:18987211]"}
{"concept_id": "C2611710", "aliases": [], "types": ["T044"], "canonical_name": "nitrile biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom. [PMID:18987211]"}
{"concept_id": "C2611711", "aliases": ["cellular response to boron levels"], "types": ["T043"], "canonical_name": "cellular response to boron-containing substance levels", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of boron-containing substances. [PMID:18952773]"}
{"concept_id": "C2611712", "aliases": ["indole-3-Acetic acid methyl ester esterase activity", "MeIAA esterase activity", "Methyl IAA esterase activity"], "types": ["T044"], "canonical_name": "methyl indole-3-acetate esterase activity", "definition": "Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+. [MetaCyc:RXN-10711, PMID:18467465]"}
{"concept_id": "C2611713", "aliases": ["methylsalicylate esterase activity", "MESA esterase activity", "methyl SA esterase activity", "salicylic acid methyl ester esterase activity"], "types": ["T044"], "canonical_name": "methyl salicylate esterase activity", "definition": "Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+. [MetaCyc:RXNQT-4366, PMID:18467465, PMID:18643994]"}
{"concept_id": "C2611714", "aliases": ["MEJA esterase activity", "methyl JA esterase activity", "jasmonic acid methyl ester esterase activity"], "types": ["T044"], "canonical_name": "methyl jasmonate esterase activity", "definition": "Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol. [PMID:15233793, PMID:18467465]"}
{"concept_id": "C2611715", "aliases": [], "types": ["T043"], "canonical_name": "response to nitrite", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus. [GOC:dhl, PMID:17951451]"}
{"concept_id": "C2611716", "aliases": [], "types": ["T040"], "canonical_name": "host response to induction by symbiont of tumor, nodule or growth in host", "definition": "Any process that results in a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the formation of an abnormal mass of cells in the host organism, induced by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:18836040]"}
{"concept_id": "C2611717", "aliases": ["progoitrin biosynthetic process", "2-hydroxy-but-3-enyl glucosinolate formation", "2-hydroxy-but-3-enyl glucosinolate anabolism", "progoitrin biosynthesis", "2-hydroxy-but-3-enyl glucosinolate biosynthesis", "progoitrin synthesis", "2-hydroxy-but-3-enyl glucosinolate synthesis"], "types": ["T044"], "canonical_name": "2-hydroxy-but-3-enyl glucosinolate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of progoitrin, a 2-hydroxy-but-3-enyl glucosinolate. Glucosinolates are substituted thioglucosides found in rapeseed products and related cruciferae, and progoitrin has been implicated in causing goiters in mammals and bitter taste in cruciferous vegetables. [PMID:11560911, PMID:18945935]"}
{"concept_id": "C2611720", "aliases": ["regulation of cytokinin mediated signalling", "regulation of cytokinin mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of cytokinin-activated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of cytokinin signaling. [GOC:dhl]"}
{"concept_id": "C2611721", "aliases": ["negative regulation of cytokinin mediated signaling pathway", "negative regulation of cytokinin mediated signalling"], "types": ["T044"], "canonical_name": "negative regulation of cytokinin-activated signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cytokinin signaling. [GOC:dhl, PMID:14973166]"}
{"concept_id": "C2611724", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cellular response to phosphate starvation", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to phosphate starvation. [PMID:18315545]"}
{"concept_id": "C2611725", "aliases": [], "types": ["T044"], "canonical_name": "ADP-ribose pyrophosphohydrolase activity", "definition": "Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate. [GOC:tb]"}
{"concept_id": "C2611726", "aliases": [], "types": ["T044"], "canonical_name": "ADP-glucose pyrophosphohydrolase activity", "definition": "Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate. [GOC:tb]"}
{"concept_id": "C2611727", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3-O-glucosyltransferase activity", "definition": "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule. [PMID:15352060]"}
{"concept_id": "C2611728", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 7-O-glucosyltransferase activity", "definition": "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule. [PMID:15352060]"}
{"concept_id": "C2611729", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3'-O-glucosyltransferase activity", "definition": "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule. [PMID:15352060]"}
{"concept_id": "C2611730", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 4'-O-glucosyltransferase activity", "definition": "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule. [PMID:15352060]"}
{"concept_id": "C2611731", "aliases": ["detection of reduced oxygen by chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of reduced oxygen by chemoreceptor signaling", "definition": "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. [GOC:mtg_cardio, ISBN:0323031951]"}
{"concept_id": "C2611732", "aliases": ["detection of increased carbon dioxide by chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of increased carbon dioxide by chemoreceptor signaling", "definition": "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. [GOC:mtg_cardio, ISBN:0323031951]"}
{"concept_id": "C2611733", "aliases": ["detection of pH by chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of pH by chemoreceptor signaling", "definition": "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors. [GOC:mtg_cardio, ISBN:0323031951]"}
{"concept_id": "C2611734", "aliases": ["detection of hypoxic conditions in blood by carotid body chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of hypoxic conditions in blood by carotid body chemoreceptor signaling", "definition": "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies. [GOC:mtg_cardio]"}
{"concept_id": "C2611735", "aliases": ["detection of hypoxic conditions in blood by aortic body chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of hypoxic conditions in blood by aortic body chemoreceptor signaling", "definition": "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies. [GOC:mtg_cardio]"}
{"concept_id": "C2611736", "aliases": ["detection of increased carbon dioxide by aortic body chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of increased carbon dioxide by aortic body chemoreceptor signaling", "definition": "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body. [GOC:mtg_cardio]"}
{"concept_id": "C2611737", "aliases": ["detection of increased carbon dioxide by carotid body chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of increased carbon dioxide by carotid body chemoreceptor signaling", "definition": "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body. [GOC:mtg_cardio]"}
{"concept_id": "C2611738", "aliases": ["detection of pH by aortic body chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of pH by aortic body chemoreceptor signaling", "definition": "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body. [GOC:mtg_cardio]"}
{"concept_id": "C2611739", "aliases": ["detection of pH by carotid body chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of pH by carotid body chemoreceptor signaling", "definition": "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body. [GOC:mtg_cardio]"}
{"concept_id": "C2611740", "aliases": ["detection of reduced oxygen by aortic body chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of reduced oxygen by aortic body chemoreceptor signaling", "definition": "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body. [GOC:mtg_cardio]"}
{"concept_id": "C2611741", "aliases": ["detection of reduced oxygen by carotid body chemoreceptor signalling"], "types": ["T043"], "canonical_name": "detection of reduced oxygen by carotid body chemoreceptor signaling", "definition": "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body. [GOC:mtg_cardio]"}
{"concept_id": "C2611743", "aliases": [], "types": ["T044"], "canonical_name": "L-iditol (sorbitol) dehydrogenase activity"}
{"concept_id": "C2611745", "aliases": [], "types": ["T044"], "canonical_name": "NAD+-dependent sorbitol dehydrogenase activity"}
{"concept_id": "C2611746", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent sorbitol dehydrogenase activity"}
{"concept_id": "C2611747", "aliases": [], "types": ["T044"], "canonical_name": "NAD-sorbitol dehydrogenase"}
{"concept_id": "C2611748", "aliases": [], "types": ["T044"], "canonical_name": "CTP:diacylglycerol kinase activity"}
{"concept_id": "C2611752", "aliases": [], "types": ["T045"], "canonical_name": "S-genotype-assocd. glycoproteins"}
{"concept_id": "C2611757", "aliases": [], "types": ["T044"], "canonical_name": "Cu-Zn superoxide dismutase activity"}
{"concept_id": "C2611758", "aliases": [], "types": ["T044"], "canonical_name": "protein serine/threonine phosphatase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611759", "aliases": [], "types": ["T044"], "canonical_name": "cytokine receptor activity", "definition": "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:mah]"}
{"concept_id": "C2611761", "aliases": ["type II TGF-beta binding", "TGF-beta type II binding", "transforming growth factor beta receptor type II binding"], "types": ["T044"], "canonical_name": "type II transforming growth factor beta receptor binding", "definition": "Binding to a type II transforming growth factor beta receptor. [GOC:ceb, GOC:mah, PMID:11252892]"}
{"concept_id": "C2611762", "aliases": [], "types": ["T044"], "canonical_name": "APO binding"}
{"concept_id": "C2611763", "aliases": [], "types": ["T044"], "canonical_name": "EDAR binding"}
{"concept_id": "C2611764", "aliases": [], "types": ["T044"], "canonical_name": "FAS binding"}
{"concept_id": "C2611765", "aliases": [], "types": ["T044"], "canonical_name": "KILLER binding"}
{"concept_id": "C2611766", "aliases": [], "types": ["T044"], "canonical_name": "NGFR binding"}
{"concept_id": "C2611767", "aliases": [], "types": ["T044"], "canonical_name": "TNFR1 binding"}
{"concept_id": "C2611770", "aliases": [], "types": ["T043"], "canonical_name": "ribosomal large subunit assembly", "definition": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl]"}
{"concept_id": "C2611771", "aliases": [], "types": ["T043"], "canonical_name": "ribosomal small subunit assembly", "definition": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. [GOC:jl]"}
{"concept_id": "C2611772", "aliases": ["autophagic vacuole assembly", "autophagosome formation", "autophagosome biosynthesis", "autophagic vacuole formation"], "types": ["T043"], "canonical_name": "autophagosome assembly", "definition": "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. [GOC:autophagy, PMID:9412464]"}
{"concept_id": "C2611773", "aliases": [], "types": ["T043"], "canonical_name": "PAS formation"}
{"concept_id": "C2611777", "aliases": ["RNAP II complex location", "RNA polymerase II complex location", "RNAP II complex"], "types": ["T026"], "canonical_name": "RNA polymerase II complex"}
{"concept_id": "C2611779", "aliases": ["17S U2 snRNP location"], "types": ["T026"], "canonical_name": "17S U2 snRNP"}
{"concept_id": "C2611780", "aliases": ["12S U11 snRNP location"], "types": ["T026"], "canonical_name": "12S U11 snRNP"}
{"concept_id": "C2611781", "aliases": [], "types": ["T026"], "canonical_name": "55S ribosome, mitochondrial"}
{"concept_id": "C2611782", "aliases": [], "types": ["T026"], "canonical_name": "39S ribosomal subunit, mitochondrial"}
{"concept_id": "C2611783", "aliases": [], "types": ["T026"], "canonical_name": "28S ribosomal subunit, mitochondrial"}
{"concept_id": "C2611786", "aliases": ["VTC", "ER-Golgi transport container", "pre-Golgi intermediate compartment", "ERGIC", "endoplasmic reticulum-Golgi transport container", "EGTC", "vesicular-tubular cluster", "ER-Golgi intermediate compartment"], "types": ["T026"], "canonical_name": "endoplasmic reticulum-Golgi intermediate compartment", "definition": "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. [GOC:pr, PMID:16723730]"}
{"concept_id": "C2611787", "aliases": ["late Golgi"], "types": ["T026"], "canonical_name": "late Golgi"}
{"concept_id": "C2611789", "aliases": ["modulator complex location"], "types": ["T026"], "canonical_name": "modulator complex"}
{"concept_id": "C2611791", "aliases": [], "types": ["T026"], "canonical_name": "PA28gamma-20S proteasome"}
{"concept_id": "C2611792", "aliases": ["NCBP-NIP1 complex location"], "types": ["T026"], "canonical_name": "NCBP-NIP1 complex"}
{"concept_id": "C2611794", "aliases": ["PI3-kinase p85-subunit alpha- PI3-kinase p110 complex location"], "types": ["T026"], "canonical_name": "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex"}
{"concept_id": "C2611795", "aliases": ["PIK3C3-PIK3R4 complex location"], "types": ["T026"], "canonical_name": "PIK3C3-PIK3R4 complex"}
{"concept_id": "C2611796", "aliases": ["PIK3CA-PIK3R1 complex location"], "types": ["T026"], "canonical_name": "PIK3CA-PIK3R1 complex"}
{"concept_id": "C2611797", "aliases": ["DNA-dependent protein kinase-DNA ligase 4 complex location"], "types": ["T026"], "canonical_name": "DNA-dependent protein kinase-DNA ligase 4 complex", "definition": "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV. [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889]"}
{"concept_id": "C2611800", "aliases": [], "types": ["T045"], "canonical_name": "tRNA splicing, via endonucleolytic cleavage and ligation", "definition": "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. [GOC:krc, ISBN:0879695897, PMID:9582290]"}
{"concept_id": "C2611801", "aliases": ["protein sorting along secretory pathway"], "types": ["T044"], "canonical_name": "protein sorting along secretory pathway"}
{"concept_id": "C2611802", "aliases": [], "types": ["T044"], "canonical_name": "maintenance of protein location in ER lumen"}
{"concept_id": "C2611803", "aliases": ["activation-induced B-cell apoptosis", "AICD", "activation-induced cell death of B lymphocytes", "activation-induced B cell apoptosis", "activation-induced B cell apoptotic process", "activation-induced cell death of B cells", "activation-induced cell death of B-lymphocytes"], "types": ["T043"], "definition": "B cell apoptotic process that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death. [GOC:mtg_apoptosis, GOC:tfm, PMID:11032170, PMID:19300454]", "canonical_name": "activation-induced cell death of B-cells"}
{"concept_id": "C2611804", "aliases": ["antigen-driven apoptosis"], "types": ["T043"], "canonical_name": "antigen-driven apoptosis"}
{"concept_id": "C2611805", "aliases": [], "types": ["T040"], "canonical_name": "response to abiotic stress"}
{"concept_id": "C2611806", "aliases": ["response to biotic stress"], "types": ["T040"], "canonical_name": "response to biotic stress"}
{"concept_id": "C2611807", "aliases": ["nuclear envelope organization and biogenesis", "nuclear envelope organisation"], "types": ["T043"], "canonical_name": "nuclear envelope organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. [GOC:dph, GOC:ems, GOC:jl, GOC:mah]"}
{"concept_id": "C2611808", "aliases": [], "types": ["T043"], "canonical_name": "microtubule catastrophe"}
{"concept_id": "C2611809", "aliases": ["tubulin assembly"], "types": ["T044"], "canonical_name": "tubulin complex assembly", "definition": "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. [GOC:mah]"}
{"concept_id": "C2611810", "aliases": [], "types": ["T043"], "canonical_name": "microtubule rescue"}
{"concept_id": "C2611811", "aliases": [], "types": ["T043"], "canonical_name": "cell-substrate adherens junction assembly"}
{"concept_id": "C2611812", "aliases": ["signalling cascade"], "types": ["T043"], "canonical_name": "signaling cascade"}
{"concept_id": "C2611813", "aliases": [], "types": ["T044"], "canonical_name": "JNK1 cascade"}
{"concept_id": "C2611814", "aliases": [], "types": ["T044"], "canonical_name": "JNK2 cascade"}
{"concept_id": "C2611815", "aliases": [], "types": ["T044"], "canonical_name": "JNK3 cascade"}
{"concept_id": "C2611816", "aliases": [], "types": ["T044"], "canonical_name": "MAPK10 cascade"}
{"concept_id": "C2611817", "aliases": [], "types": ["T044"], "canonical_name": "MAPK8 cascade"}
{"concept_id": "C2611818", "aliases": [], "types": ["T044"], "canonical_name": "MAPK9 cascade"}
{"concept_id": "C2611820", "aliases": ["positive transcription elongation factor complex b"], "types": ["T026"], "canonical_name": "positive transcription elongation factor complex location b"}
{"concept_id": "C2611821", "aliases": ["intracellular ferritin complex location"], "types": ["T026"], "canonical_name": "intracellular ferritin complex", "definition": "A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains. [GOC:jl, GOC:mah, PMID:19154717]"}
{"concept_id": "C2611822", "aliases": ["sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor"], "types": ["T043"], "canonical_name": "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor"}
{"concept_id": "C2611831", "aliases": ["MAPK signalling"], "types": ["T044"], "canonical_name": "MAPK signaling"}
{"concept_id": "C2611837", "aliases": ["exosome (RNase complex)", "exosome (ribonucleasease complex)", "exosome multienzyme ribonuclease complex", "exosome multienzyme ribonuclease complex location", "exosome (ribonucleasease complex location)"], "types": ["T026"], "definition": "A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. [PMID:17174896, PMID:20531386, PMID:26726035]", "canonical_name": "exosome (RNase complex location)"}
{"concept_id": "C2611838", "aliases": [], "types": ["T044"], "canonical_name": "peptidase activity, acting on peptides containing modified amino acids"}
{"concept_id": "C2611843", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (cytosine-C5-)-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA. [GOC:imk, PMID:10026269, PMID:18786544]"}
{"concept_id": "C2611845", "aliases": [], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA poly(A) tail shortening", "definition": "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. [GOC:krc]"}
{"concept_id": "C2611846", "aliases": [], "types": ["T045"], "canonical_name": "nuclear mRNA poly(A) tail shortening"}
{"concept_id": "C2611847", "aliases": [], "types": ["T040"], "canonical_name": "response of host to symbiont"}
{"concept_id": "C2611850", "aliases": [], "types": ["T040"], "canonical_name": "regulation of circadian rhythm phase"}
{"concept_id": "C2611853", "aliases": ["myrosinase binding"], "types": ["T044"], "canonical_name": "thioglucosidase binding", "definition": "Binding to a thioglucosidase enzyme. [GOC:tb]"}
{"concept_id": "C2611854", "aliases": [], "types": ["T039"], "canonical_name": "response to continuous far red light stimulus by the high-irradiance response system", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence. [GOC:mtg_far_red, GOC:sm]"}
{"concept_id": "C2611855", "aliases": [], "types": ["T039"], "canonical_name": "response to very low fluence red light stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec. [GOC:mtg_far_red, GOC:sm]"}
{"concept_id": "C2611857", "aliases": [], "types": ["T042"], "canonical_name": "floral evocation"}
{"concept_id": "C2611858", "aliases": ["response to low fluence blue light by blf system"], "types": ["T043"], "canonical_name": "response to low fluence blue light stimulus by blue low-fluence system", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes. [GOC:mtg_far_red, PMID:10398709]"}
{"concept_id": "C2611860", "aliases": [], "types": ["T039"], "canonical_name": "regulation of the circadian clock by temperature"}
{"concept_id": "C2611862", "aliases": ["abscisate binding", "ABA binding"], "types": ["T044"], "canonical_name": "abscisic acid binding", "definition": "Binding to abscisic acid, a plant hormone that regulates aspects of plant growth. [PMID:17347412]"}
{"concept_id": "C2611863", "aliases": ["long-distance propagation of posttranscriptional gene silencing"], "types": ["T045"], "canonical_name": "long-distance posttranscriptional gene silencing"}
{"concept_id": "C2611864", "aliases": [], "types": ["T043"], "canonical_name": "regulation of reciprocal meiotic recombination", "definition": "Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611866", "aliases": [], "types": ["T043"], "canonical_name": "regulation of double-strand break repair via homologous recombination", "definition": "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. [GOC:dph, GOC:jp, GOC:tb]"}
{"concept_id": "C2611867", "aliases": [], "types": ["T040"], "canonical_name": "regulation of filamentous growth", "definition": "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. [GOC:dph, GOC:jp, GOC:tb]"}
{"concept_id": "C2611868", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA replication during S phase"}
{"concept_id": "C2611869", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of platelet activation", "definition": "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2611870", "aliases": ["VEGF production"], "types": ["T040"], "canonical_name": "vascular endothelial growth factor production", "definition": "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rl]"}
{"concept_id": "C2611871", "aliases": [], "types": ["T040"], "canonical_name": "regulation of vascular endothelial growth factor production", "definition": "Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. [GOC:rl]"}
{"concept_id": "C2611872", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of vascular endothelial growth factor production", "definition": "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2611873", "aliases": [], "types": ["T044"], "canonical_name": "metalloenzyme regulator activity"}
{"concept_id": "C2611874", "aliases": [], "types": ["T044"], "canonical_name": "metalloenzyme activator activity"}
{"concept_id": "C2611875", "aliases": ["regulation of adenylate cyclase activity involved in G-protein signaling pathway", "regulation of adenylate cyclase activity involved in G-protein signalling", "regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G protein-coupled receptor signaling pathway. [GOC:dph, GOC:signaling, GOC:tb]"}
{"concept_id": "C2611877", "aliases": [], "types": ["T044"], "canonical_name": "regulation of starch biosynthetic process", "definition": "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch. [GOC:tb]"}
{"concept_id": "C2611878", "aliases": [], "types": ["T039"], "canonical_name": "floral meristem determinacy", "definition": "The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate). [PMID:18441215]"}
{"concept_id": "C2611879", "aliases": [], "types": ["T043"], "canonical_name": "response to cyclopentenone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid. [PMID:18334669]"}
{"concept_id": "C2611880", "aliases": [], "types": ["T042"], "canonical_name": "pollen exine formation", "definition": "The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine. [GOC:dhl]"}
{"concept_id": "C2611881", "aliases": [], "types": ["T043"], "canonical_name": "glutamine secretion", "definition": "The controlled release of glutamine by a cell. [PMID:15208395]"}
{"concept_id": "C2611882", "aliases": ["microRNA catabolic process"], "types": ["T045"], "canonical_name": "miRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. [PMID:17993620]"}
{"concept_id": "C2611883", "aliases": [], "types": ["T040"], "canonical_name": "cotyledon vascular tissue pattern formation", "definition": "Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants. [PMID:10559439]"}
{"concept_id": "C2611884", "aliases": [], "types": ["T042"], "canonical_name": "leaf proximal/distal pattern formation", "definition": "The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis. [PMID:18398054]"}
{"concept_id": "C2611886", "aliases": ["regulation of lamellipodium biogenesis"], "types": ["T043"], "canonical_name": "regulation of lamellipodium assembly", "definition": "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611887", "aliases": ["positive regulation of lamellipodium biogenesis"], "types": ["T043"], "canonical_name": "positive regulation of lamellipodium assembly", "definition": "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611888", "aliases": ["negative regulation of lamellipodium biogenesis"], "types": ["T043"], "canonical_name": "negative regulation of lamellipodium assembly", "definition": "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611889", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelial cell migration", "definition": "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611890", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endothelial cell migration", "definition": "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611891", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell migration", "definition": "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611892", "aliases": [], "types": ["T044"], "canonical_name": "green leaf volatile biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid. [PMID:17163881]"}
{"concept_id": "C2611893", "aliases": ["NAD(P)H dehydrogenase complex location (plastoquinone)"], "types": ["T026"], "canonical_name": "NAD(P)H dehydrogenase complex (plastoquinone)", "definition": "Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool. [PMID:15608332]"}
{"concept_id": "C2611894", "aliases": ["primary lsiRNA processing", "production of lsiRNA involved in RNA interference", "RNA interference, production of lsiRNA"], "types": ["T045"], "canonical_name": "lsiRNA processing", "definition": "A process leading to the generation of a functional long small interfering RNA (lsiRNA). lsiRNAs are class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions. [PMID:18003861, PMID:20687832]"}
{"concept_id": "C2611895", "aliases": [], "types": ["T044"], "canonical_name": "regulation of auxin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. [PMID:18287041]"}
{"concept_id": "C2611896", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of auxin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. [PMID:18287041]"}
{"concept_id": "C2611897", "aliases": [], "types": ["T043"], "canonical_name": "regulation of 1-aminocyclopropane-1-carboxylate metabolic process", "definition": "Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. [PMID:18055613]"}
{"concept_id": "C2611898", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cytoplasmic mRNA processing body assembly", "definition": "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. [GOC:dph, GOC:krc, GOC:tb]"}
{"concept_id": "C2611899", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of macromolecule metabolic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611900", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of macromolecule metabolic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611901", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cytoplasmic mRNA processing body assembly", "definition": "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. [GOC:dph, GOC:krc, GOC:tb]"}
{"concept_id": "C2611902", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cytoplasmic mRNA processing body assembly", "definition": "Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. [GOC:dph, GOC:krc, GOC:tb]"}
{"concept_id": "C2611903", "aliases": ["posttranscriptional regulation of gene expression"], "types": ["T045"], "canonical_name": "post-transcriptional regulation of gene expression", "definition": "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611904", "aliases": ["posttranscriptional regulation of gene expression by mRNA localization", "posttranscriptional regulation of gene expression by mRNA localisation", "mRNA localisation resulting in posttranscriptional regulation of gene expression", "mRNA localization resulting in posttranscriptional regulation of gene expression"], "types": ["T045"], "canonical_name": "mRNA localization resulting in post-transcriptional regulation of gene expression", "definition": "Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611905", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA stability involved in response to stress", "definition": "Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611906", "aliases": [], "types": ["T046"], "canonical_name": "regulation of cardiac muscle hypertrophy", "definition": "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611907", "aliases": [], "types": ["T046"], "canonical_name": "regulation of cardiac muscle adaptation", "definition": "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611908", "aliases": [], "types": ["T046"], "canonical_name": "positive regulation of cardiac muscle hypertrophy", "definition": "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611909", "aliases": [], "types": ["T046"], "canonical_name": "negative regulation of cardiac muscle hypertrophy", "definition": "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611910", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of cardiac muscle adaptation", "definition": "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611911", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of cardiac muscle adaptation", "definition": "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611912", "aliases": ["circadian regulation of cytosolic free calcium ion oscillation", "circadian regulation of cytosolic calcium ion homeostasis", "circadian regulation of Ca2+ oscillation", "circadian regulation of [Ca2+]cyt oscillation"], "types": ["T040"], "canonical_name": "circadian regulation of calcium ion oscillation", "definition": "Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours. [PMID:17982000]"}
{"concept_id": "C2611913", "aliases": [], "types": ["T042"], "canonical_name": "aerenchyma formation", "definition": "The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts. [PMID:18055613, PO:0005702]"}
{"concept_id": "C2611915", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription by transcription factor catabolism", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:bf, GOC:dph, GOC:tb]"}
{"concept_id": "C2611916", "aliases": ["negative regulation of transcription by transcription factor localisation"], "types": ["T045"], "canonical_name": "negative regulation of transcription by transcription factor localization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611917", "aliases": [], "types": ["T042"], "canonical_name": "specification of ovule identity", "definition": "The regionalization process in which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tb]"}
{"concept_id": "C2611918", "aliases": [], "types": ["T043"], "canonical_name": "developmental programmed cell death"}
{"concept_id": "C2611919", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Schwann cell proliferation", "definition": "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2611920", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Schwann cell proliferation", "definition": "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2611921", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Schwann cell proliferation", "definition": "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2611923", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene expression", "definition": "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]"}
{"concept_id": "C2611924", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of gene expression", "definition": "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]"}
{"concept_id": "C2611925", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription, start site selection", "definition": "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611926", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration", "definition": "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism. [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611927", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial cell migration", "definition": "Any process that modulates the frequency, rate or extent of epithelial cell migration. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611928", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of epithelial cell migration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611929", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of epithelial cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of epithelial cell migration. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611930", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial fusion", "definition": "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611931", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial fusion", "definition": "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611932", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial fusion", "definition": "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611933", "aliases": ["positive regulation of organelle organization and biogenesis", "positive regulation of organelle organisation"], "types": ["T043"], "canonical_name": "positive regulation of organelle organization", "definition": "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611934", "aliases": ["negative regulation of organelle organization and biogenesis", "negative regulation of organelle organisation"], "types": ["T043"], "canonical_name": "negative regulation of organelle organization", "definition": "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611935", "aliases": ["regulation of platelet-derived growth factor receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of platelet-derived growth factor receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2611936", "aliases": ["positive regulation of platelet-derived growth factor receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of platelet-derived growth factor receptor signaling pathway", "definition": "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2611937", "aliases": ["negative regulation of platelet-derived growth factor receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of platelet-derived growth factor receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2611938", "aliases": [], "types": ["T043"], "canonical_name": "cell communication by chemical coupling", "definition": "The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2611939", "aliases": [], "types": ["T043"], "canonical_name": "cell communication by electrical coupling", "definition": "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2611940", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell communication by chemical coupling", "definition": "Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2611941", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell communication", "definition": "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611942", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell communication", "definition": "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611943", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell communication", "definition": "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611944", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell communication by electrical coupling", "definition": "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2611945", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell communication by electrical coupling", "definition": "Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2611946", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell communication by electrical coupling", "definition": "Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2611947", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell communication by chemical coupling", "definition": "Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2611948", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell communication by chemical coupling", "definition": "Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C2611949", "aliases": [], "types": ["T043"], "canonical_name": "apical cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611951", "aliases": ["negative regulation of muscle cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of muscle cell apoptotic process", "definition": "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611952", "aliases": ["muscle cell apoptosis"], "types": ["T043"], "canonical_name": "muscle cell apoptotic process", "definition": "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611953", "aliases": ["striated muscle cell apoptosis"], "types": ["T043"], "canonical_name": "striated muscle cell apoptotic process", "definition": "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611954", "aliases": ["cardiac muscle cell apoptosis"], "types": ["T043"], "canonical_name": "cardiac muscle cell apoptotic process", "definition": "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611955", "aliases": ["regulation of muscle cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of muscle cell apoptotic process", "definition": "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611956", "aliases": ["positive regulation of muscle cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of muscle cell apoptotic process", "definition": "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611957", "aliases": ["regulation of striated muscle cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of striated muscle cell apoptotic process", "definition": "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611958", "aliases": ["positive regulation of striated muscle cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of striated muscle cell apoptotic process", "definition": "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611959", "aliases": ["negative regulation of striated muscle cell apoptosis", "down-regulation of striated muscle cell apoptosis", "down regulation of striated muscle cell apoptosis", "downregulation of striated muscle cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of striated muscle cell apoptotic process", "definition": "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]"}
{"concept_id": "C2611960", "aliases": ["regulation of cardiac muscle cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of cardiac muscle cell apoptotic process", "definition": "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611961", "aliases": ["positive regulation of cardiac muscle cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of cardiac muscle cell apoptotic process", "definition": "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2611962", "aliases": ["down-regulation of cardiac muscle cell apoptosis", "downregulation of cardiac muscle cell apoptosis", "down regulation of cardiac muscle cell apoptosis", "negative regulation of cardiac muscle cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of cardiac muscle cell apoptotic process", "definition": "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]"}
{"concept_id": "C2611963", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardiac muscle cell apoptosis"}
{"concept_id": "C2611964", "aliases": [], "types": ["T043"], "canonical_name": "ectodermal cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611965", "aliases": [], "types": ["T042"], "canonical_name": "epithelial structure maintenance", "definition": "A tissue homeostatic process required for the maintenance of epithelial structure. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611968", "aliases": ["regulation of transcription from RNA polymerase II promoter, meiotic"], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle", "definition": "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. [GOC:dph, GOC:tb, PMID:12161753]"}
{"concept_id": "C2611969", "aliases": ["positive regulation of transcription from RNA polymerase II promoter, meiotic"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. [GOC:dph, GOC:tb, PMID:8618927]"}
{"concept_id": "C2611970", "aliases": ["negative regulation of transcription from RNA polymerase II promoter, meiotic"], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle", "definition": "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. [GOC:dph, GOC:tb, PMID:8618927]"}
{"concept_id": "C2611971", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular carbohydrate metabolic process", "definition": "Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611972", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cellular carbohydrate metabolic process", "definition": "Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611973", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular carbohydrate metabolic process", "definition": "Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611974", "aliases": ["negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-dependent", "negative regulation of cellular carbohydrate metabolic process by transcriptional repression", "negative regulation of cellular carbohydrate metabolic process by repression of transcription"], "types": ["T045"], "canonical_name": "negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-templated", "definition": "Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611979", "aliases": ["tricyclic triterpenoid metabolism"], "types": ["T044"], "canonical_name": "tricyclic triterpenoid metabolic process", "definition": "The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings. [GOC:tair_curators]"}
{"concept_id": "C2611980", "aliases": ["tricyclic triterpenoid catabolism"], "types": ["T044"], "canonical_name": "tricyclic triterpenoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings. [GOC:tair_curators]"}
{"concept_id": "C2611981", "aliases": ["tetracyclic triterpenoid metabolism"], "types": ["T044"], "canonical_name": "tetracyclic triterpenoid metabolic process", "definition": "The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings. [GOC:tair_curators]"}
{"concept_id": "C2611982", "aliases": ["tetracyclic triterpenoid biosynthesis"], "types": ["T044"], "canonical_name": "tetracyclic triterpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings. [GOC:tair_curators]"}
{"concept_id": "C2611984", "aliases": ["negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of ribosomal protein gene transcription by RNA polymerase II", "definition": "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2611985", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus", "definition": "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2611986", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress", "definition": "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2611987", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels", "definition": "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2611988", "aliases": [], "types": ["T044"], "canonical_name": "regulation of alkaline phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611989", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of alkaline phosphatase activity", "definition": "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2611990", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of alkaline phosphatase activity", "definition": "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611991", "aliases": ["regulation of SPB separation"], "types": ["T043"], "canonical_name": "regulation of mitotic spindle pole body separation", "definition": "Any process that modulates the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]"}
{"concept_id": "C2611992", "aliases": ["positive regulation of SPB separation"], "types": ["T043"], "canonical_name": "positive regulation of mitotic spindle pole body separation", "definition": "Any process that increases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]"}
{"concept_id": "C2611993", "aliases": ["negative regulation of SPB separation"], "types": ["T043"], "canonical_name": "negative regulation of mitotic spindle pole body separation", "definition": "Any process that decreases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]"}
{"concept_id": "C2611994", "aliases": ["acetyltransferase stimulator activity"], "types": ["T044"], "canonical_name": "acetyltransferase activator activity", "definition": "Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule. [GOC:dph, GOC:jp, GOC:tb, PMID:23912279]"}
{"concept_id": "C2611995", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell signaling involved in quorum sensing"}
{"concept_id": "C2611996", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of norepinephrine secretion", "definition": "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2611997", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of norepinephrine secretion", "definition": "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612001", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA double-strand break processing involved in meiotic gene conversion", "definition": "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612002", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA double-strand break processing involved in reciprocal meiotic recombination", "definition": "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612003", "aliases": ["lactosylceramide biosynthesis leading to ganglioside", "lactosylceramide biosynthetic process leading to ganglioside"], "types": ["T044"], "canonical_name": "biosynthesis of lactosylceramide precursor to ganglioside"}
{"concept_id": "C2612004", "aliases": ["lactosylceramide biosynthetic process leading to globoside", "lactosylceramide biosynthesis leading to globoside"], "types": ["T044"], "canonical_name": "biosynthesis of lactosylceramide precursor to globoside"}
{"concept_id": "C2612006", "aliases": [], "types": ["T045"], "canonical_name": "heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing", "definition": "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612007", "aliases": ["regulation of collagen catabolism", "regulation of collagen degradation", "regulation of collagen breakdown"], "types": ["T044"], "canonical_name": "regulation of collagen catabolic process", "definition": "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612008", "aliases": ["down regulation of collagen catabolic process", "negative regulation of collagen degradation", "down-regulation of collagen catabolic process", "negative regulation of collagen breakdown", "negative regulation of collagen catabolism", "downregulation of collagen catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of collagen catabolic process", "definition": "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612009", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of collagen catabolic process"}
{"concept_id": "C2612010", "aliases": ["regulation of collagen metabolism"], "types": ["T044"], "canonical_name": "regulation of collagen metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612011", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of collagen metabolic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612012", "aliases": ["positive regulation of collagen metabolism"], "types": ["T044"], "canonical_name": "positive regulation of collagen metabolic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612013", "aliases": ["regulation of extracellular matrix degradation", "regulation of extracellular matrix breakdown"], "types": ["T043"], "canonical_name": "regulation of extracellular matrix disassembly", "definition": "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612014", "aliases": ["negative regulation of extracellular matrix degradation", "downregulation of extracellular matrix disassembly", "negative regulation of extracellular matrix breakdown", "down-regulation of extracellular matrix disassembly", "down regulation of extracellular matrix disassembly"], "types": ["T043"], "canonical_name": "negative regulation of extracellular matrix disassembly", "definition": "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612015", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of extracellular matrix disassembly"}
{"concept_id": "C2612016", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial to mesenchymal transition", "definition": "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612017", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of epithelial to mesenchymal transition", "definition": "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612018", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of epithelial to mesenchymal transition", "definition": "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612019", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell development", "definition": "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612020", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell development", "definition": "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612021", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ferrochelatase activity", "definition": "Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612022", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to iron", "definition": "Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612023", "aliases": ["regulation of definitive RBC differentiation", "regulation of definitive red blood cell differentiation", "regulation of definitive erythropoiesis"], "types": ["T043"], "canonical_name": "regulation of definitive erythrocyte differentiation", "definition": "Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C2612024", "aliases": ["regulation of primitive red blood cell differentiation", "regulation of primitive RBC differentiation", "regulation of primitive erythropoeisis"], "types": ["T043"], "canonical_name": "regulation of primitive erythrocyte differentiation", "definition": "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C2612025", "aliases": ["positive regulation of hydrogen peroxide metabolism"], "types": ["T044"], "canonical_name": "positive regulation of hydrogen peroxide metabolic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2612026", "aliases": ["negative regulation of hydrogen peroxide metabolism"], "types": ["T044"], "canonical_name": "negative regulation of hydrogen peroxide metabolic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2612027", "aliases": ["regulation of hydrogen peroxide biosynthesis"], "types": ["T044"], "canonical_name": "regulation of hydrogen peroxide biosynthetic process", "definition": "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2612028", "aliases": ["positive regulation of hydrogen peroxide biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of hydrogen peroxide biosynthetic process", "definition": "Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2612029", "aliases": ["negative regulation of hydrogen peroxide biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of hydrogen peroxide biosynthetic process", "definition": "Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2612030", "aliases": ["protein amino acid glutathionylation"], "types": ["T044"], "canonical_name": "protein glutathionylation", "definition": "The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2612031", "aliases": ["regulation of protein amino acid glutathionylation"], "types": ["T044"], "canonical_name": "regulation of protein glutathionylation", "definition": "Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2612032", "aliases": ["positive regulation of protein amino acid glutathionylation"], "types": ["T044"], "canonical_name": "positive regulation of protein glutathionylation", "definition": "Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2612033", "aliases": ["negative regulation of protein amino acid glutathionylation"], "types": ["T044"], "canonical_name": "negative regulation of protein glutathionylation", "definition": "Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2612034", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription via serum response element binding", "definition": "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2612035", "aliases": [], "types": ["T045"], "canonical_name": "serum response element binding", "definition": "Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2612036", "aliases": ["protein kinase A signaling cascade", "protein kinase A signalling cascade", "PKA signaling cascade", "protein kinase A signal transduction"], "types": ["T044"], "canonical_name": "protein kinase A signaling", "definition": "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612037", "aliases": ["regulation of protein kinase A signalling cascade", "regulation of protein kinase A signaling cascade", "regulation of PKA signaling cascade"], "types": ["T044"], "canonical_name": "regulation of protein kinase A signaling", "definition": "Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612038", "aliases": ["positive regulation of protein kinase A signaling cascade", "positive regulation of protein kinase A signalling cascade", "positive regulation of PKA signaling cascade"], "types": ["T044"], "canonical_name": "positive regulation of protein kinase A signaling", "definition": "Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612045", "aliases": ["regulation of plasma membrane long-chain fatty acid transport"], "types": ["T044"], "canonical_name": "regulation of long-chain fatty acid import across plasma membrane", "definition": "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612046", "aliases": ["positive regulation of plasma membrane long-chain fatty acid transport"], "types": ["T044"], "canonical_name": "positive regulation of long-chain fatty acid import across plasma membrane", "definition": "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612047", "aliases": ["negative regulation of plasma membrane long-chain fatty acid transport"], "types": ["T044"], "canonical_name": "negative regulation of long-chain fatty acid import across plasma membrane", "definition": "Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612048", "aliases": ["regulation of nitric oxide-mediated signal transduction"], "types": ["T044"], "canonical_name": "regulation of nitric oxide mediated signal transduction", "definition": "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612049", "aliases": ["positive regulation of nitric oxide-mediated signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of nitric oxide mediated signal transduction", "definition": "Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612050", "aliases": ["negative regulation of nitric oxide-mediated signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of nitric oxide mediated signal transduction", "definition": "Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612051", "aliases": ["regulation of cGMP-mediated signalling"], "types": ["T044"], "canonical_name": "regulation of cGMP-mediated signaling", "definition": "Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612052", "aliases": ["positive regulation of cGMP-mediated signalling"], "types": ["T044"], "canonical_name": "positive regulation of cGMP-mediated signaling", "definition": "Any process that increases the rate, frequency or extent of cGMP-mediated signaling. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612053", "aliases": ["negative regulation of cGMP-mediated signalling"], "types": ["T044"], "canonical_name": "negative regulation of cGMP-mediated signaling", "definition": "Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612054", "aliases": [], "types": ["T044"], "canonical_name": "regulation of plasminogen activation", "definition": "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612055", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of plasminogen activation", "definition": "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612056", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of plasminogen activation", "definition": "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612057", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of plasminogen activation"}
{"concept_id": "C2612058", "aliases": [], "types": ["T043"], "canonical_name": "regulation of macrophage chemotaxis", "definition": "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612059", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of macrophage chemotaxis", "definition": "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612060", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of macrophage chemotaxis", "definition": "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612061", "aliases": ["fibroblast cell migration"], "types": ["T043"], "canonical_name": "fibroblast migration", "definition": "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612062", "aliases": ["regulation of fibroblast cell migration"], "types": ["T043"], "canonical_name": "regulation of fibroblast migration", "definition": "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612063", "aliases": ["positive regulation of fibroblast cell migration"], "types": ["T043"], "canonical_name": "positive regulation of fibroblast migration", "definition": "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612064", "aliases": ["negative regulation of fibroblast cell migration"], "types": ["T043"], "canonical_name": "negative regulation of fibroblast migration", "definition": "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612065", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of sodium ion transport", "definition": "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612066", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of sodium ion transport", "definition": "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612067", "aliases": ["regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage"], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage", "definition": "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612068", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cell morphogenesis involved in differentiation", "definition": "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612069", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell morphogenesis involved in differentiation", "definition": "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612070", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell morphogenesis involved in differentiation", "definition": "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612071", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA recombinase assembly involved in reciprocal meiotic recombination", "definition": "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612072", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA recombinase assembly involved in meiotic gene conversion", "definition": "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612073", "aliases": [], "types": ["T045"], "canonical_name": "meiotic strand invasion involved in reciprocal meiotic recombination", "definition": "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612074", "aliases": [], "types": ["T045"], "canonical_name": "meiotic strand invasion involved in meiotic gene conversion", "definition": "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612075", "aliases": [], "types": ["T045"], "canonical_name": "meiotic mismatch repair involved in meiotic gene conversion", "definition": "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612076", "aliases": [], "types": ["T045"], "canonical_name": "meiotic mismatch repair involved in reciprocal meiotic recombination", "definition": "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612077", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA repair synthesis involved in reciprocal meiotic recombination", "definition": "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612078", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA repair synthesis involved in meiotic gene conversion", "definition": "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612079", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "definition": "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612080", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA double-strand break formation involved in meiotic gene conversion", "definition": "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612081", "aliases": [], "types": ["T042"], "canonical_name": "proboscis morphogenesis, labial disc-derived", "definition": "The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612082", "aliases": [], "types": ["T042"], "canonical_name": "proboscis morphogenesis, eye-antennal disc-derived", "definition": "The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612083", "aliases": [], "types": ["T042"], "canonical_name": "proboscis morphogenesis, clypeo-labral disc-derived", "definition": "The process in which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612084", "aliases": [], "types": ["T043"], "canonical_name": "clathrin coating of Golgi vesicle, plasma membrane to endosome targeting", "definition": "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612085", "aliases": [], "types": ["T043"], "canonical_name": "clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting", "definition": "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612086", "aliases": [], "types": ["T043"], "canonical_name": "COPI coating of Golgi vesicle, inter-Golgi cisterna", "definition": "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612087", "aliases": [], "types": ["T043"], "canonical_name": "COPI coating of Golgi vesicle, cis-Golgi to rough ER", "definition": "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612088", "aliases": [], "types": ["T043"], "canonical_name": "meiotic sister chromatid cohesion involved in meiosis I", "definition": "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612089", "aliases": [], "types": ["T043"], "canonical_name": "meiotic sister chromatid cohesion involved in meiosis II", "definition": "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612090", "aliases": [], "types": ["T045"], "canonical_name": "DNA double-strand break processing involved in repair via synthesis-dependent strand annealing", "definition": "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612091", "aliases": [], "types": ["T045"], "canonical_name": "DNA double-strand break processing involved in repair via single-strand annealing", "definition": "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612092", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mRNA export from nucleus", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612093", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dolichol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612094", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ubiquinone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612095", "aliases": [], "types": ["T043"], "canonical_name": "regulation of multivesicular body size", "definition": "Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles. [GOC:dph, GOC:jp, GOC:tb]"}
{"concept_id": "C2612096", "aliases": [], "types": ["T043"], "canonical_name": "regulation of multivesicular body size involved in endosome transport", "definition": "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612097", "aliases": [], "types": ["T043"], "canonical_name": "regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism", "definition": "Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612098", "aliases": [], "types": ["T044"], "canonical_name": "regulation of peptidyl-threonine phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612099", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of peptidyl-threonine phosphorylation", "definition": "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612100", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of peptidyl-threonine phosphorylation", "definition": "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612102", "aliases": ["regulation of TNF-mediated signaling pathway", "regulation of TNF signaling", "regulation of tumor necrosis factor-mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of tumor necrosis factor-mediated signaling pathway", "definition": "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612103", "aliases": ["negative regulation of TNF-mediated signaling pathway", "negative regulation of tumor necrosis factor-mediated signalling pathway", "negative regulation of TNF signaling"], "types": ["T044"], "canonical_name": "negative regulation of tumor necrosis factor-mediated signaling pathway", "definition": "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612106", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle priming", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511]"}
{"concept_id": "C2612107", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle priming", "definition": "Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511]"}
{"concept_id": "C2612108", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle priming", "definition": "Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. [GOC:dph, GOC:kmvs, GOC:tb, PMID:15489511]"}
{"concept_id": "C2612109", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell-substrate adhesion", "definition": "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. [GOC:dph, GOC:pf, GOC:tb]"}
{"concept_id": "C2612110", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell-substrate adhesion", "definition": "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. [GOC:dph, GOC:pf, GOC:tb]"}
{"concept_id": "C2612111", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell-substrate adhesion", "definition": "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. [GOC:dph, GOC:pf, GOC:tb]"}
{"concept_id": "C2612112", "aliases": [], "types": ["T044"], "canonical_name": "neuropeptide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612113", "aliases": [], "types": ["T044"], "canonical_name": "substance P catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2612114", "aliases": [], "types": ["T044"], "canonical_name": "bradykinin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2612115", "aliases": [], "types": ["T044"], "canonical_name": "calcitonin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2612116", "aliases": [], "types": ["T038"], "canonical_name": "regulation of hormone levels", "definition": "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612117", "aliases": ["T-cell chemotaxis"], "types": ["T043"], "canonical_name": "T cell chemotaxis", "definition": "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612118", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T cell chemotaxis", "definition": "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612119", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of T cell chemotaxis", "definition": "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612120", "aliases": ["regulation of mitochondrion organisation"], "types": ["T043"], "canonical_name": "regulation of mitochondrion organization", "definition": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612121", "aliases": ["positive regulation of mitochondrion organisation"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrion organization", "definition": "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612122", "aliases": ["negative regulation of mitochondrion organisation"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrion organization", "definition": "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612123", "aliases": [], "types": ["T043"], "canonical_name": "regulation of centrosome duplication", "definition": "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612124", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of centrosome duplication", "definition": "Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612125", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of centrosome duplication", "definition": "Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612126", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glucose transport"}
{"concept_id": "C2612127", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glucose transport"}
{"concept_id": "C2612128", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glucose transport"}
{"concept_id": "C2612129", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myotube differentiation", "definition": "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612130", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of myotube differentiation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612131", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myotube differentiation", "definition": "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612132", "aliases": [], "types": ["T045"], "canonical_name": "telomere maintenance via telomere lengthening", "definition": "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612134", "aliases": ["regulation of protein amino acid ADP-ribosylation"], "types": ["T044"], "canonical_name": "regulation of protein ADP-ribosylation", "definition": "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612135", "aliases": ["negative regulation of protein amino acid ADP-ribosylation"], "types": ["T044"], "canonical_name": "negative regulation of protein ADP-ribosylation", "definition": "Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612136", "aliases": [], "types": ["T043"], "canonical_name": "regulation of keratinocyte proliferation", "definition": "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612137", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of keratinocyte proliferation", "definition": "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612138", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of keratinocyte proliferation", "definition": "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612139", "aliases": [], "types": ["T040"], "canonical_name": "regulation of circadian sleep/wake cycle, wakefulness", "definition": "Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612140", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of circadian sleep/wake cycle, wakefulness", "definition": "Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612141", "aliases": ["retinal lamination", "retinal layer formation"], "types": ["T042"], "canonical_name": "retina layer formation", "definition": "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266]"}
{"concept_id": "C2612143", "aliases": ["DNA binding, recombination hotspot"], "types": ["T045"], "canonical_name": "recombination hotspot binding", "definition": "Binding to a genomic region which promotes recombination. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612144", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of reciprocal meiotic recombination", "definition": "Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612145", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of meiotic recombination"}
{"concept_id": "C2612146", "aliases": [], "types": ["T043"], "canonical_name": "activation of reciprocal meiotic recombination", "definition": "Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612147", "aliases": [], "types": ["T043"], "canonical_name": "activation of meiotic recombination"}
{"concept_id": "C2612148", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chromatin assembly", "definition": "Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612150", "aliases": ["regulation of hydrogen ion transporting ATPase activity, rotational mechanism"], "types": ["T044"], "canonical_name": "regulation of proton-transporting ATPase activity, rotational mechanism", "definition": "Any process that modulates the rate of ATP hydrolysis by an ATPase. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612151", "aliases": [], "types": ["T044"], "canonical_name": "regulation of V-type ATPase activity"}
{"concept_id": "C2612153", "aliases": [], "types": ["T044"], "canonical_name": "cyclase regulator activity", "definition": "Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612154", "aliases": [], "types": ["T044"], "canonical_name": "cyclase inhibitor activity", "definition": "Decreases the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612155", "aliases": [], "types": ["T044"], "canonical_name": "cyclase activator activity", "definition": "Increases the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612156", "aliases": [], "types": ["T044"], "canonical_name": "adenylate cyclase regulator activity", "definition": "Binds to and modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612157", "aliases": [], "types": ["T044"], "canonical_name": "adenylate cyclase inhibitor activity", "definition": "Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612158", "aliases": [], "types": ["T044"], "canonical_name": "adenylate cyclase activator activity", "definition": "Increases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612159", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent protein kinase activity", "definition": "Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612160", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent protein kinase regulator activity", "definition": "Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612161", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent cysteine-type endopeptidase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612164", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pathway-restricted SMAD protein phosphorylation", "definition": "Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612165", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phospholipase C activity", "definition": "Any process that increases the rate of phospholipase C activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612166", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of protein histidine kinase activity", "definition": "Any process that increases the frequency, rate or extent of protein histidine kinase activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612167", "aliases": [], "types": ["T039"], "canonical_name": "stipule development", "definition": "The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms. [GOC:tb]"}
{"concept_id": "C2612168", "aliases": ["regulation of triacylglycerol biosynthetic process"], "types": ["T044"], "canonical_name": "regulation of triglyceride biosynthetic process", "definition": "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612169", "aliases": ["positive regulation of triacylglycerol biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of triglyceride biosynthetic process", "definition": "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612170", "aliases": ["negative regulation of triacylglycerol biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of triglyceride biosynthetic process", "definition": "Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612174", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cholesterol esterification", "definition": "Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612175", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cholesterol esterification", "definition": "Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612176", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cholesterol efflux", "definition": "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612177", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cholesterol efflux", "definition": "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612178", "aliases": ["lipid localisation"], "types": ["T039"], "canonical_name": "lipid localization", "definition": "Any process in which a lipid is transported to, or maintained in, a specific location. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612179", "aliases": [], "types": ["T043"], "canonical_name": "lipid transport involved in lipid storage", "definition": "The directed movement of lipids into cells that is part of their accumulation and maintenance. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612180", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol storage", "definition": "The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612181", "aliases": ["sequestration of cholesterol"], "types": ["T044"], "canonical_name": "cholesterol sequestration"}
{"concept_id": "C2612182", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol transport involved in cholesterol storage", "definition": "The directed movement of cholesterol into cells that is part of their accumulation and maintenance. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612183", "aliases": [], "types": ["T043"], "canonical_name": "regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "definition": "Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612184", "aliases": [], "types": ["T042"], "canonical_name": "regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612185", "aliases": ["regulation of cardiac muscle contraction by calcium ion signalling"], "types": ["T042"], "canonical_name": "regulation of cardiac muscle contraction by calcium ion signaling", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612186", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lipid storage", "definition": "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612187", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lipid sequestration"}
{"concept_id": "C2612188", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of lipid storage", "definition": "Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612189", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of lipid sequestration"}
{"concept_id": "C2612190", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cholesterol storage", "definition": "Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612191", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cholesterol storage", "definition": "Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612192", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cholesterol sequestration"}
{"concept_id": "C2612193", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cholesterol storage", "definition": "Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612194", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cholesterol sequestration"}
{"concept_id": "C2612195", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lipid storage", "definition": "Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612196", "aliases": ["regulation of triacylglycerol sequestration", "regulation of sequestering of triacylglycerol"], "types": ["T044"], "canonical_name": "regulation of sequestering of triglyceride", "definition": "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612197", "aliases": ["positive regulation of triglyceride sequestration", "positive regulation of sequestering of triacylglycerol"], "types": ["T044"], "canonical_name": "positive regulation of sequestering of triglyceride", "definition": "Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612198", "aliases": ["negative regulation of sequestering of triacylglycerol", "negative regulation of triglyceride sequestration"], "types": ["T044"], "canonical_name": "negative regulation of sequestering of triglyceride", "definition": "Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612199", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial translation in response to stress", "definition": "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress. [GOC:dph, GOC:jp, GOC:tb, PMID:8830768]"}
{"concept_id": "C2612200", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of steroid biosynthetic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [GOC:tb]"}
{"concept_id": "C2612201", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of steroid biosynthetic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612202", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ergosterol biosynthetic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol. [GOC:tb]"}
{"concept_id": "C2612203", "aliases": ["regulation of triacylglycerol catabolic process"], "types": ["T044"], "canonical_name": "regulation of triglyceride catabolic process", "definition": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. [GOC:rn, GOC:tb]"}
{"concept_id": "C2612204", "aliases": ["negative regulation of triacylglycerol catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of triglyceride catabolic process", "definition": "Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. [GOC:rn, GOC:tb]"}
{"concept_id": "C2612205", "aliases": ["positive regulation of triacylglycerol catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of triglyceride catabolic process", "definition": "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. [GOC:rn, GOC:tb]"}
{"concept_id": "C2612206", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphatidylcholine catabolic process", "definition": "Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612207", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphatidylcholine catabolic process", "definition": "Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612208", "aliases": ["regulation of VLDL remodeling"], "types": ["T043"], "canonical_name": "regulation of very-low-density lipoprotein particle remodeling", "definition": "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. [GOC:tb]"}
{"concept_id": "C2612209", "aliases": ["positive regulation of VLDL remodeling"], "types": ["T043"], "canonical_name": "positive regulation of very-low-density lipoprotein particle remodeling", "definition": "Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. [GOC:tb]"}
{"concept_id": "C2612210", "aliases": ["negative regulation of VLDL remodeling"], "types": ["T043"], "canonical_name": "negative regulation of very-low-density lipoprotein particle remodeling", "definition": "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. [GOC:tb]"}
{"concept_id": "C2612211", "aliases": ["regulation of UDP-glucose catabolism"], "types": ["T044"], "canonical_name": "regulation of UDP-glucose catabolic process", "definition": "Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612212", "aliases": ["negative regulation of UDP-glucose catabolism"], "types": ["T044"], "canonical_name": "negative regulation of UDP-glucose catabolic process", "definition": "Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612213", "aliases": ["regulation of glucose metabolism"], "types": ["T044"], "canonical_name": "regulation of glucose metabolic process", "definition": "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612214", "aliases": ["positive regulation of glucose metabolism"], "types": ["T044"], "canonical_name": "positive regulation of glucose metabolic process", "definition": "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. [GOC:BHF, GOC:tb]"}
{"concept_id": "C2612215", "aliases": [], "types": ["T044"], "canonical_name": "regulation of heparan sulfate proteoglycan biosynthetic process", "definition": "Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612216", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heparan sulfate proteoglycan biosynthetic process", "definition": "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612217", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity", "definition": "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612218", "aliases": [], "types": ["T044"], "canonical_name": "regulation of isomerase activity", "definition": "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612219", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of isomerase activity", "definition": "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612220", "aliases": [], "types": ["T044"], "canonical_name": "regulation of sterigmatocystin biosynthetic process", "definition": "Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612221", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of sterigmatocystin biosynthetic process", "definition": "Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612222", "aliases": ["regulation of VLDL clearance", "regulation of VLDL particle clearance"], "types": ["T043"], "canonical_name": "regulation of very-low-density lipoprotein particle clearance", "definition": "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612223", "aliases": ["negative regulation of VLDL particle clearance", "negative regulation of VLDL clearance"], "types": ["T043"], "canonical_name": "negative regulation of very-low-density lipoprotein particle clearance", "definition": "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612224", "aliases": ["reduction of mitochondrial membrane potential"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial membrane potential", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612225", "aliases": ["elevation of mitochondrial membrane potential"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane potential", "definition": "Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612226", "aliases": ["regulation of inositol phosphate biosynthesis"], "types": ["T044"], "canonical_name": "regulation of inositol phosphate biosynthetic process", "definition": "Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612227", "aliases": ["negative regulation of inositol phosphate biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of inositol phosphate biosynthetic process", "definition": "Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612228", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphatase activity", "definition": "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612229", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phosphatase activity", "definition": "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612230", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphatase activity", "definition": "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612231", "aliases": [], "types": ["T044"], "canonical_name": "regulation of inositol-polyphosphate 5-phosphatase activity", "definition": "Any process that modulates the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612232", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of inositol-polyphosphate 5-phosphatase activity", "definition": "Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612234", "aliases": [], "types": ["T043"], "canonical_name": "cellular component assembly involved in morphogenesis", "definition": "The cellular component assembly that is part of the initial shaping of the component during its developmental progression. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612235", "aliases": ["regulation of auxin mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of auxin mediated signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612236", "aliases": ["positive regulation of auxin mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of auxin mediated signaling pathway", "definition": "Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612237", "aliases": ["negative regulation of auxin mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of auxin mediated signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612238", "aliases": [], "types": ["T038"], "canonical_name": "macrophage tolerance induction", "definition": "A process involving any mechanism for tolerance induction in macrophages. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612239", "aliases": [], "types": ["T038"], "canonical_name": "regulation of macrophage tolerance induction", "definition": "Any process that modulates the frequency, rate, or extent of macrophage tolerance induction. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612240", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of macrophage tolerance induction", "definition": "Any process that increases the frequency, rate, or extent of B cell tolerance induction. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2612241", "aliases": [], "types": ["T040"], "canonical_name": "macrophage cytokine production", "definition": "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2612242", "aliases": [], "types": ["T040"], "canonical_name": "regulation of macrophage cytokine production", "definition": "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2612243", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of macrophage cytokine production", "definition": "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2612244", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic microtubule depolymerization", "definition": "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612245", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic microtubule depolymerization", "definition": "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. [GOC:dph, GOC:tb]"}
{"concept_id": "C2612246", "aliases": [], "types": ["T043"], "canonical_name": "regulation of necrotic cell death", "definition": "Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. [PMID:16507998]"}
{"concept_id": "C2612247", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of necrotic cell death", "definition": "Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. [PMID:16507998]"}
{"concept_id": "C2612249", "aliases": [], "types": ["T044"], "canonical_name": "NADPH pyrophosphatase activity", "definition": "Catalysis of the reaction: NADPH + H2O = NMNH + ADP. [GOC:tb]"}
{"concept_id": "C2612250", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription by competitive promoter binding", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site. [GOC:tb]"}
{"concept_id": "C2612251", "aliases": [], "types": ["T043"], "canonical_name": "nonapoptotic programmed cell death"}
{"concept_id": "C2612252", "aliases": [], "types": ["T040"], "canonical_name": "regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:mtg_muscle]"}
{"concept_id": "C2612253", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:mtg_muscle]"}
{"concept_id": "C2612254", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:mtg_muscle]"}
{"concept_id": "C2612255", "aliases": [], "types": ["T044"], "canonical_name": "heparin proteoglycan biosynthetic process"}
{"concept_id": "C2612256", "aliases": [], "types": ["T044"], "canonical_name": "heparin proteoglycan biosynthetic process, linkage to polypeptide"}
{"concept_id": "C2612257", "aliases": [], "types": ["T044"], "canonical_name": "heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process"}
{"concept_id": "C2612258", "aliases": [], "types": ["T044"], "canonical_name": "heparin proteoglycan biosynthetic process, enzymatic modification"}
{"concept_id": "C2612260", "aliases": [], "types": ["T044"], "canonical_name": "heparin-alpha-glucosaminide N-acetyltransferase activity"}
{"concept_id": "C2612261", "aliases": [], "types": ["T044"], "canonical_name": "[heparan sulfate]-sulfate lyase activity"}
{"concept_id": "C2612264", "aliases": [], "types": ["T044"], "canonical_name": "siroheme sulfite reductase activity"}
{"concept_id": "C2612267", "aliases": ["nitric oxide synthase-dystrophin complex location, skeletal muscle"], "types": ["T026"], "canonical_name": "nitric oxide synthase-dystrophin complex, skeletal muscle"}
{"concept_id": "C2612269", "aliases": ["cellular component biogenesis at cellular level"], "types": ["T043"], "canonical_name": "cellular component biogenesis", "definition": "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. [GOC:jl, GOC:mah]"}
{"concept_id": "C2612270", "aliases": ["spliceosomal A complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal A complex formation"}
{"concept_id": "C2612271", "aliases": ["spliceosomal B complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal B complex formation"}
{"concept_id": "C2612272", "aliases": ["spliceosomal A2-2 complex biosynthesis", "formation of spliceosomal A2-2 complex"], "types": ["T045"], "canonical_name": "spliceosomal A2-2 complex formation"}
{"concept_id": "C2612273", "aliases": ["spliceosomal C1 complex biosynthesis", "formation of spliceosomal C1 complex"], "types": ["T045"], "canonical_name": "spliceosomal C1 complex formation"}
{"concept_id": "C2612274", "aliases": ["spliceosomal A2-3 complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal A2-3 complex formation"}
{"concept_id": "C2612275", "aliases": ["spliceosomal C2 complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal C2 complex formation"}
{"concept_id": "C2612276", "aliases": ["formation of spliceosomal A2-1 complex", "spliceosomal A2-1 complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal A2-1 complex formation"}
{"concept_id": "C2612277", "aliases": ["spliceosomal B1 complex biosynthesis", "formation of spliceosomal B1 complex"], "types": ["T045"], "canonical_name": "spliceosomal B1 complex formation"}
{"concept_id": "C2612278", "aliases": ["nuclear mRNA trans splicing, via spliceosome"], "types": ["T045"], "canonical_name": "mRNA trans splicing, via spliceosome", "definition": "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. [GOC:krc, ISBN:0879695897, PMID:18458335]"}
{"concept_id": "C2612279", "aliases": ["spliceosomal A1 complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal A1 complex formation"}
{"concept_id": "C2612280", "aliases": ["spliceosomal B2 complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal B2 complex formation"}
{"concept_id": "C2612281", "aliases": [], "types": ["T045"], "canonical_name": "U12-type spliceosome disassembly"}
{"concept_id": "C2612282", "aliases": [], "types": ["T045"], "canonical_name": "U2-type spliceosome disassembly"}
{"concept_id": "C2612283", "aliases": ["spliceosomal CC complex biosynthesis"], "types": ["T045"], "canonical_name": "spliceosomal CC complex formation"}
{"concept_id": "C2612284", "aliases": [], "types": ["T026"], "canonical_name": "perivacuolar space"}
{"concept_id": "C2612285", "aliases": [], "types": ["T026"], "canonical_name": "phagophore assembly site", "definition": "Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction. [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]"}
{"concept_id": "C2612286", "aliases": ["synaptic vesicle budding involved in synaptic vesicle endocytosis", "synaptic vesicle budding from pre-synaptic membrane"], "types": ["T043"], "canonical_name": "synaptic vesicle budding from presynaptic endocytic zone membrane", "definition": "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle. [GOC:curators, PMID:10099709, PMID:20448150]"}
{"concept_id": "C2612287", "aliases": ["prolyl 4-hydroxylase complex location"], "types": ["T026"], "canonical_name": "prolyl 4-hydroxylase complex"}
{"concept_id": "C2612290", "aliases": ["AML1 complex location"], "types": ["T026"], "canonical_name": "AML1 complex"}
{"concept_id": "C2612291", "aliases": ["PEPB2 complex location"], "types": ["T026"], "canonical_name": "PEPB2 complex"}
{"concept_id": "C2612294", "aliases": ["oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor", "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor", "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor", "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]"}
{"concept_id": "C2612295", "aliases": [], "types": ["T044"], "canonical_name": "aryl hydrocarbon hydroxylase activity"}
{"concept_id": "C2612296", "aliases": [], "types": ["T044"], "canonical_name": "aryl-4-monooxygenase activity"}
{"concept_id": "C2612297", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 CYP19"}
{"concept_id": "C2612300", "aliases": [], "types": ["T044"], "canonical_name": "microsomal monooxygenase activity"}
{"concept_id": "C2612301", "aliases": ["microsomal p450 activity"], "types": ["T044"], "canonical_name": "microsomal P-450"}
{"concept_id": "C2612303", "aliases": [], "types": ["T044"], "canonical_name": "xenobiotic monooxygenase activity"}
{"concept_id": "C2612306", "aliases": [], "types": ["T044"], "canonical_name": "3'-tyrosyl-DNA phosphodiesterase activity", "definition": "Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. [PMID:10521354, PMID:16751265]"}
{"concept_id": "C2612307", "aliases": ["melanocyte stimulating hormone activity"], "types": ["T043"], "canonical_name": "melanocyte-stimulating hormone activity", "definition": "The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates. [ISBN:0198506732]"}
{"concept_id": "C2612310", "aliases": [], "types": ["T044"], "canonical_name": "heparin 6-O-sulfotransferase activity"}
{"concept_id": "C2612315", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-alanine trimethylation", "definition": "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine. [RESID:AA0062]"}
{"concept_id": "C2612316", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-proline dimethylation", "definition": "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline. [RESID:AA0066]"}
{"concept_id": "C2612317", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine trimethylation", "definition": "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. [RESID:AA0074]"}
{"concept_id": "C2612318", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine monomethylation", "definition": "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. [RESID:AA0076]"}
{"concept_id": "C2612319", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine dimethylation", "definition": "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. [RESID:AA0075]"}
{"concept_id": "C2612320", "aliases": ["2,3-dihydroxy-p-cumate 3,4-dioxygenase", "2,3-dihydroxy-p-cumate dioxygenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate. [RHEA:42568]", "canonical_name": "2,3-dihydroxy-p-cumate-3,4-dioxygenase"}
{"concept_id": "C2612321", "aliases": [], "types": ["T044"], "canonical_name": "1,1,1-trichloroethane reductive dehalogenase activity", "definition": "Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl. [UM-BBD_reactionID:r1007]"}
{"concept_id": "C2612324", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside diphosphate-sugar hydrolase activity"}
{"concept_id": "C2612326", "aliases": [], "types": ["T045"], "canonical_name": "regulation of telomere length"}
{"concept_id": "C2612331", "aliases": ["aerobic ammonia oxidation to nitrite via hydrazine"], "types": ["T043"], "canonical_name": "aerobic respiration, using ammonia as electron donor", "definition": "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite. [MetaCyc:AMMOXID-PWY]"}
{"concept_id": "C2612332", "aliases": ["assimilatory sulphate reduction"], "types": ["T044"], "canonical_name": "assimilatory sulfate reduction"}
{"concept_id": "C2612333", "aliases": [], "types": ["T044"], "canonical_name": "L-alanine oxidation to D-lactate and ammonia", "definition": "The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia. [MetaCyc:ALACAT2-PWY]"}
{"concept_id": "C2612338", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-alanine monomethylation", "definition": "The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine. [RESID:AA0061]"}
{"concept_id": "C2612339", "aliases": ["Atg12 conjugating enzyme activity", "APG12 conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y -> Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C2612345", "aliases": [], "types": ["T044"], "canonical_name": "IL binding"}
{"concept_id": "C2612346", "aliases": [], "types": ["T026"], "canonical_name": "paired organelles"}
{"concept_id": "C2612347", "aliases": [], "types": ["T026"], "canonical_name": "toxoneme"}
{"concept_id": "C2612349", "aliases": [], "types": ["T026"], "canonical_name": "polyphosphate vacuole"}
{"concept_id": "C2612352", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of cell shape and cell size"}
{"concept_id": "C2612353", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of cell shape and cell size"}
{"concept_id": "C2612354", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cell shape and cell size"}
{"concept_id": "C2612355", "aliases": [], "types": ["T043"], "canonical_name": "microvillus assembly", "definition": "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. [GOC:mah, ISBN:0815316194]"}
{"concept_id": "C2612356", "aliases": [], "types": ["T026"], "canonical_name": "hemi-adherens junction"}
{"concept_id": "C2612359", "aliases": [], "types": ["T044"], "canonical_name": "heparin proteoglycan catabolic process"}
{"concept_id": "C2612360", "aliases": [], "types": ["T044"], "canonical_name": "heparin proteoglycan metabolic process"}
{"concept_id": "C2612361", "aliases": [], "types": ["T044"], "canonical_name": "heparan sulfate metabolic process"}
{"concept_id": "C2612362", "aliases": [], "types": ["T044"], "canonical_name": "heparan sulfate biosynthetic process"}
{"concept_id": "C2612363", "aliases": [], "types": ["T044"], "canonical_name": "heparan sulfate catabolic process"}
{"concept_id": "C2612367", "aliases": [], "types": ["T040"], "canonical_name": "lethargus"}
{"concept_id": "C2612370", "aliases": [], "types": ["T026"], "canonical_name": "preribosome, large subunit precursor", "definition": "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. [PMID:10567516]"}
{"concept_id": "C2612371", "aliases": [], "types": ["T026"], "canonical_name": "preribosome, small subunit precursor", "definition": "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. [PMID:10567516]"}
{"concept_id": "C2612372", "aliases": ["centromere complex", "chromosome, centric region", "centromere complex location"], "types": ["T026"], "canonical_name": "chromosome, centromeric region", "definition": "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]"}
{"concept_id": "C2612373", "aliases": ["condensed chromosome, centric region"], "types": ["T026"], "canonical_name": "condensed chromosome, centromeric region", "definition": "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. [GOC:elh, GOC:kmv]"}
{"concept_id": "C2612375", "aliases": ["13S condensin complex location"], "types": ["T026"], "canonical_name": "13S condensin complex"}
{"concept_id": "C2612377", "aliases": [], "types": ["T043"], "canonical_name": "cell morphogenesis involved in differentiation", "definition": "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. [GOC:go_curators]"}
{"concept_id": "C2612378", "aliases": [], "types": ["T040"], "canonical_name": "imperfect stage fruiting body development"}
{"concept_id": "C2612380", "aliases": [], "types": ["T043"], "canonical_name": "preprophase band assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation. [GOC:clt, GOC:mah]"}
{"concept_id": "C2612381", "aliases": [], "types": ["T043"], "canonical_name": "cell plate assembly", "definition": "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast. [GOC:clt]"}
{"concept_id": "C2612382", "aliases": ["nuclear mRNA degradation", "nuclear mRNA breakdown", "nuclear mRNA catabolism"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. [GOC:krc]"}
{"concept_id": "C2612383", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial RNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612384", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial mRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612385", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial RNA metabolic process", "definition": "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612386", "aliases": [], "types": ["T044"], "canonical_name": "regulation of mitochondrial RNA catabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612387", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of mitochondrial RNA catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612388", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of mitochondrial RNA catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612389", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial RNA processing", "definition": "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612390", "aliases": ["mitochondrial RNA 5' end processing"], "types": ["T045"], "canonical_name": "mitochondrial RNA 5'-end processing", "definition": "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612391", "aliases": ["mitochondrial RNA 3' end processing"], "types": ["T045"], "canonical_name": "mitochondrial RNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612392", "aliases": ["RNA 5' end processing"], "types": ["T045"], "canonical_name": "RNA 5'-end processing", "definition": "Any process involved in forming the mature 5' end of an RNA molecule. [GOC:krc]"}
{"concept_id": "C2612393", "aliases": ["rRNA 5' end processing"], "types": ["T045"], "canonical_name": "rRNA 5'-end processing", "definition": "Any process involved in forming the mature 5' end of an rRNA molecule. [GOC:krc]"}
{"concept_id": "C2612394", "aliases": [], "types": ["T043"], "canonical_name": "P granule organization and biogenesis"}
{"concept_id": "C2612400", "aliases": ["DNA synthesome complex location"], "types": ["T026"], "canonical_name": "DNA synthesome complex"}
{"concept_id": "C2612401", "aliases": ["RC complex location"], "types": ["T026"], "canonical_name": "RC complex"}
{"concept_id": "C2612402", "aliases": ["replication-competent complex location"], "types": ["T026"], "canonical_name": "replication-competent complex"}
{"concept_id": "C2612405", "aliases": [], "types": ["T043"], "canonical_name": "astral microtubule nucleation", "definition": "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. [GOC:mah]"}
{"concept_id": "C2612406", "aliases": ["erUPR", "ER unfolded protein response"], "types": ["T044"], "canonical_name": "endoplasmic reticulum unfolded protein response", "definition": "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. [GOC:mah, PMID:12042763]"}
{"concept_id": "C2612407", "aliases": [], "types": ["T045"], "canonical_name": "deadenylation-independent decapping of nuclear mRNA"}
{"concept_id": "C2612408", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of microtubule catastrophe"}
{"concept_id": "C2612409", "aliases": [], "types": ["T044"], "canonical_name": "metallo-sulfur cluster biosynthesis"}
{"concept_id": "C2612411", "aliases": [], "types": ["T043"], "canonical_name": "actin rod assembly", "definition": "The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules. [GOC:pg, PMID:14706699]"}
{"concept_id": "C2612412", "aliases": ["mating projection assembly"], "types": ["T043"], "canonical_name": "mating projection formation", "definition": "The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi. [GOC:mah, PMID:14734532]"}
{"concept_id": "C2612413", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mating projection assembly", "definition": "Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi. [PMID:14734532]"}
{"concept_id": "C2612415", "aliases": ["cell envelope Sec protein transport complex location"], "types": ["T026"], "canonical_name": "cell envelope Sec protein transport complex", "definition": "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC. [GOC:mtg_sensu, PMID:15223057]"}
{"concept_id": "C2612416", "aliases": ["Sec secretion complex location"], "types": ["T026"], "canonical_name": "Sec secretion complex"}
{"concept_id": "C2612417", "aliases": ["Sec translocation complex location"], "types": ["T026"], "canonical_name": "Sec translocation complex"}
{"concept_id": "C2612418", "aliases": ["activation of phospholipase D activity"], "types": ["T044"], "canonical_name": "activation of phospholipase D activity", "definition": "Any process that initiates the activity of inactive phospholipase D. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2612420", "aliases": ["microtubule basal body organization", "microtubule basal body organization and biogenesis", "microtubule basal body organisation"], "types": ["T043"], "canonical_name": "ciliary basal body organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum). [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124]"}
{"concept_id": "C2612422", "aliases": ["plasma membrane blebbing", "plasma membrane bleb assembly", "cell blebbing"], "types": ["T043"], "canonical_name": "bleb assembly", "definition": "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]"}
{"concept_id": "C2612424", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of secretory granule location", "definition": "Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2612425", "aliases": ["maintenance of dense core vesicle location"], "types": ["T038"], "canonical_name": "maintenance of dense core granule location", "definition": "Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2612426", "aliases": [], "types": ["T043"], "canonical_name": "myelin assembly", "definition": "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. [GOC:dgh, GOC:dph, GOC:tb]"}
{"concept_id": "C2612432", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein location in cell", "definition": "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. [GOC:isa_complete, GOC:mah]"}
{"concept_id": "C2612433", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein localization in cell"}
{"concept_id": "C2612434", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microvillus assembly", "definition": "A process that modulates the formation of a microvillus. [GOC:mah]"}
{"concept_id": "C2612439", "aliases": [], "types": ["T039"], "canonical_name": "expulsion of gland contents"}
{"concept_id": "C2612440", "aliases": ["TAT protein transport complex location"], "types": ["T026"], "canonical_name": "TAT protein transport complex", "definition": "A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins. [GOC:pamgo_curators]"}
{"concept_id": "C2612441", "aliases": ["TAT protein secretion complex location"], "types": ["T026"], "canonical_name": "TAT protein secretion complex"}
{"concept_id": "C2612442", "aliases": ["Twin-arginine translocation complex location"], "types": ["T026"], "canonical_name": "Twin-arginine translocation complex"}
{"concept_id": "C2612444", "aliases": ["heptose 1-phosphate adenyltransferase activity", "D-beta-D-heptose 1-phosphate adenylyltransferase activity"], "types": ["T044"], "canonical_name": "heptose-1-phosphate adenylyltransferase activity", "definition": "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose. [MetaCyc:RXN0-4342]"}
{"concept_id": "C2612445", "aliases": [], "types": ["T044"], "canonical_name": "myricetin 3'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin. [RHEA:25629]"}
{"concept_id": "C2612446", "aliases": [], "types": ["T044"], "canonical_name": "heparin-glucosamine 3-sulfotransferase 2 activity"}
{"concept_id": "C2612447", "aliases": [], "types": ["T044"], "canonical_name": "heparin-glucosamine 3-sulfotransferase 3 activity"}
{"concept_id": "C2612451", "aliases": [], "types": ["T044"], "canonical_name": "pituitary adenylate cyclase-activating peptide receptor activity"}
{"concept_id": "C2612454", "aliases": [], "types": ["T043"], "canonical_name": "cell junction biogenesis"}
{"concept_id": "C2612455", "aliases": ["de novo NAD biosynthetic process from tryptophan"], "types": ["T044"], "canonical_name": "'de novo' NAD biosynthetic process from tryptophan", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. [PMID:17161604]"}
{"concept_id": "C2612456", "aliases": [], "types": ["T026"], "canonical_name": "plasma lipoprotein particle", "definition": "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph. [GOC:BHF, GOC:expert_pt, GOC:rl]"}
{"concept_id": "C2612457", "aliases": [], "types": ["T026"], "canonical_name": "mature chylomicron", "definition": "A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612458", "aliases": ["VLDL complex", "very-low-density lipoprotein complex", "VLDL particle", "very-low-density lipoprotein complex location", "VLDL complex location"], "types": ["T026"], "canonical_name": "very-low-density lipoprotein particle", "definition": "A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612459", "aliases": ["LDL complex location", "LDL complex", "LDL particle", "low-density lipoprotein complex", "low-density lipoprotein complex location"], "types": ["T026"], "canonical_name": "low-density lipoprotein particle", "definition": "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612460", "aliases": ["intermediate-density lipoprotein complex", "IDL complex", "IDL particle", "IDL complex location", "intermediate-density lipoprotein complex location"], "types": ["T026"], "canonical_name": "intermediate-density lipoprotein particle", "definition": "A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL). [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612461", "aliases": ["HDL complex location", "high-density lipoprotein class complex location", "HDL2", "HDL particle", "HDL3", "high-density lipoprotein particle", "HDL complex"], "types": ["T026"], "definition": "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pde, GOC:rl]", "canonical_name": "high-density lipoprotein class complex"}
{"concept_id": "C2612462", "aliases": ["discoidal high-density lipoprotein particle", "discoidal HDL", "nascent high-density lipoprotein particle"], "types": ["T026"], "definition": "A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase). [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]", "canonical_name": "nascent HDL"}
{"concept_id": "C2612463", "aliases": ["mature HDL", "mature high-density lipoprotein particle", "spherical HDL"], "types": ["T026"], "canonical_name": "spherical high-density lipoprotein particle", "definition": "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612464", "aliases": [], "types": ["T043"], "canonical_name": "macromolecular complex remodeling"}
{"concept_id": "C2612465", "aliases": [], "types": ["T043"], "canonical_name": "protein-lipid complex remodeling", "definition": "The acquisition, loss or modification of a protein or lipid within a protein-lipid complex. [GOC:BHF, GOC:mah, GOC:rl]"}
{"concept_id": "C2612466", "aliases": [], "types": ["T043"], "canonical_name": "plasma lipoprotein particle remodeling", "definition": "The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612467", "aliases": ["triacylglycerol-rich lipoprotein particle remodeling"], "types": ["T043"], "canonical_name": "triglyceride-rich lipoprotein particle remodeling", "definition": "The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612468", "aliases": [], "types": ["T043"], "canonical_name": "chylomicron remodeling", "definition": "The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612469", "aliases": [], "types": ["T043"], "canonical_name": "chylomicron remnant formation"}
{"concept_id": "C2612470", "aliases": ["VLDL remodeling"], "types": ["T043"], "canonical_name": "very-low-density lipoprotein particle remodeling", "definition": "The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612471", "aliases": ["intermediate-density lipoprotein particle formation"], "types": ["T043"], "canonical_name": "IDL formation"}
{"concept_id": "C2612472", "aliases": ["IDL remodeling"], "types": ["T043"], "canonical_name": "intermediate-density lipoprotein particle remodeling", "definition": "The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612473", "aliases": [], "types": ["T043"], "canonical_name": "LDL formation"}
{"concept_id": "C2612474", "aliases": [], "types": ["T043"], "canonical_name": "low-density lipoprotein particle formation"}
{"concept_id": "C2612475", "aliases": ["LDL remodeling"], "types": ["T043"], "canonical_name": "low-density lipoprotein particle remodeling", "definition": "The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612476", "aliases": ["HDL remodeling"], "types": ["T043"], "canonical_name": "high-density lipoprotein particle remodeling", "definition": "The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]"}
{"concept_id": "C2612477", "aliases": ["conversion of discoidal HDL to spherical HDL"], "types": ["T044"], "canonical_name": "conversion of discoidal high-density lipoprotein particle to spherical high-density lipoprotein particle", "definition": "The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle. [GOC:BHF, GOC:mah, GOC:pde]"}
{"concept_id": "C2612478", "aliases": [], "types": ["T044"], "canonical_name": "discoidal HDL remodeling"}
{"concept_id": "C2612479", "aliases": [], "types": ["T044"], "canonical_name": "discoidal high-density lipoprotein remodeling"}
{"concept_id": "C2612480", "aliases": [], "types": ["T044"], "canonical_name": "plasma lipoprotein particle assembly", "definition": "The non-covalent aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612481", "aliases": [], "types": ["T044"], "canonical_name": "chylomicron assembly", "definition": "The non-covalent aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612482", "aliases": ["VLDL assembly"], "types": ["T044"], "canonical_name": "very-low-density lipoprotein particle assembly", "definition": "The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612483", "aliases": ["HDL assembly"], "types": ["T044"], "canonical_name": "high-density lipoprotein particle assembly", "definition": "The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612484", "aliases": ["lipoprotein particle clearance"], "types": ["T043"], "canonical_name": "plasma lipoprotein particle clearance", "definition": "The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2612485", "aliases": [], "types": ["T043"], "canonical_name": "chylomicron remnant clearance", "definition": "The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded. [GOC:BHF, GOC:mah, GOC:pde]"}
{"concept_id": "C2612486", "aliases": ["LDL clearance"], "types": ["T043"], "canonical_name": "low-density lipoprotein particle clearance", "definition": "The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612487", "aliases": ["HDL clearance"], "types": ["T043"], "canonical_name": "high-density lipoprotein particle clearance", "definition": "The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612488", "aliases": ["triacylglycerol-rich lipoprotein particle"], "types": ["T026"], "canonical_name": "triglyceride-rich lipoprotein particle"}
{"concept_id": "C2612489", "aliases": ["gamma-aminobutyric acid pyruvate transaminase activity"], "types": ["T044"], "canonical_name": "4-aminobutyrate:pyruvate transaminase activity", "definition": "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine. [EC:2.6.1.96, GOC:mah]"}
{"concept_id": "C2612490", "aliases": ["25-30 S subcomplex of 90S preribosome location", "UTP-B complex location", "UTP-B complex", "Pwp2p-containing subcomplex of 90S preribosome location", "25-30 S subcomplex of 90S preribosome"], "types": ["T026"], "canonical_name": "Pwp2p-containing subcomplex of 90S preribosome", "definition": "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. [GOC:krc, PMID:15231838]"}
{"concept_id": "C2612491", "aliases": ["lipid body organization", "lipid particle organisation", "adiposome organization", "lipid particle organization", "lipid particle organization and biogenesis"], "types": ["T043"], "canonical_name": "lipid droplet organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]"}
{"concept_id": "C2612492", "aliases": ["smooth muscle cell programmed cell death by apoptosis", "apoptosis of smooth muscle cells", "smooth muscle cell apoptosis", "SMC apoptosis", "programmed cell death of smooth muscle cells by apoptosis", "programmed cell death, smooth muscle cells"], "types": ["T043"], "canonical_name": "smooth muscle cell apoptotic process", "definition": "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]"}
{"concept_id": "C2612493", "aliases": ["regulation of smooth muscle cell apoptosis", "regulation of SMC apoptosis"], "types": ["T043"], "canonical_name": "regulation of smooth muscle cell apoptotic process", "definition": "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]"}
{"concept_id": "C2612494", "aliases": ["negative regulation of SMC apoptosis", "down regulation of smooth muscle cell apoptosis", "negative regulation of smooth muscle cell apoptosis", "down-regulation of smooth muscle cell apoptosis", "downregulation of smooth muscle cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of smooth muscle cell apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]"}
{"concept_id": "C2612495", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of smooth muscle cell apoptosis"}
{"concept_id": "C2612496", "aliases": ["up-regulation of smooth muscle cell apoptosis", "positive regulation of SMC apoptosis", "up regulation of smooth muscle cell apoptosis", "upregulation of smooth muscle cell apoptosis", "positive regulation of smooth muscle cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of smooth muscle cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]"}
{"concept_id": "C2612497", "aliases": ["stimulation of smooth muscle cell apoptosis"], "types": ["T043"], "canonical_name": "activation of smooth muscle cell apoptosis"}
{"concept_id": "C2612498", "aliases": ["protein localization at cell surface", "protein localisation at cell surface"], "types": ["T043"], "canonical_name": "protein localization to cell surface", "definition": "A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. [GOC:mah]"}
{"concept_id": "C2612499", "aliases": ["regulation of specific transcription from RNA polymerase II promoter in response to iron"], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter in response to iron", "definition": "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus. [GO_REF:0000021, GOC:mah]"}
{"concept_id": "C2612500", "aliases": ["down regulation of transcription from RNA polymerase II promoter in response to iron", "negative regulation of transcription from Pol II promoter in response to iron", "downregulation of transcription from RNA polymerase II promoter in response to iron", "down-regulation of transcription from RNA polymerase II promoter in response to iron"], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter in response to iron", "definition": "Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus. [GOC:mah]"}
{"concept_id": "C2612501", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription from RNA polymerase II promoter in response to iron"}
{"concept_id": "C2612502", "aliases": ["telomere localisation"], "types": ["T045"], "canonical_name": "telomere localization", "definition": "Any process in which a telomere is transported to, and/or maintained in, a specific location. [GOC:mah, GOC:vw]"}
{"concept_id": "C2612503", "aliases": [], "types": ["T045"], "canonical_name": "telomere tethering at nuclear periphery", "definition": "The process in which a telomere is maintained in a specific location at the nuclear periphery. [GOC:mah]"}
{"concept_id": "C2612504", "aliases": [], "types": ["T026"], "canonical_name": "nuclear periphery", "definition": "The portion of the nuclear lumen proximal to the inner nuclear membrane. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612505", "aliases": [], "types": ["T026"], "canonical_name": "gerontoplast", "definition": "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence. [PMID:12654863, PMID:24668747]"}
{"concept_id": "C2612507", "aliases": [], "types": ["T044"], "canonical_name": "recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex", "definition": "The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript. [PMID:18195044]"}
{"concept_id": "C2612508", "aliases": ["alignment of 3' and 5' splice sites of nuclear mRNA"], "types": ["T045"], "canonical_name": "alignment of 3' and 5' splice sites of mRNA", "definition": "Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur. [GOC:krc, PMID:9430647]"}
{"concept_id": "C2612509", "aliases": ["nucleobase, nucleoside and nucleotide biosynthesis", "nucleobase, nucleoside and nucleotide formation", "nucleobase, nucleoside and nucleotide anabolism", "nucleobase, nucleoside and nucleotide synthesis"], "types": ["T045"], "canonical_name": "nucleobase-containing small molecule biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. [GOC:mah]"}
{"concept_id": "C2612510", "aliases": [], "types": ["T039"], "canonical_name": "response to fluid shear stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. [GOC:sl]"}
{"concept_id": "C2612511", "aliases": ["cell wall beta-glucan metabolism"], "types": ["T043"], "canonical_name": "cell wall beta-glucan metabolic process", "definition": "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells. [GOC:mah]"}
{"concept_id": "C2612512", "aliases": ["cell wall 1,3-beta-D-glucan metabolic process", "cell wall beta-1,3 glucan metabolic process", "cell wall 1,3-beta-glucan metabolic process", "cell wall 1,3-beta-glucan metabolism", "cell wall beta-1,3 glucan metabolism"], "types": ["T044"], "canonical_name": "cell wall (1->3)-beta-D-glucan metabolic process", "definition": "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells. [GOC:mah]"}
{"concept_id": "C2612513", "aliases": ["ascospore wall beta-glucan metabolism"], "types": ["T044"], "canonical_name": "ascospore wall beta-glucan metabolic process", "definition": "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores. [GOC:mah]"}
{"concept_id": "C2612514", "aliases": ["ascospore wall beta-1,3 glucan metabolism", "ascospore wall beta-1,3 glucan metabolic process", "ascospore wall 1,3-beta-D-glucan metabolic process", "ascospore wall 1,3-beta-glucan metabolism", "ascospore wall 1,3-beta-glucan metabolic process"], "types": ["T044"], "canonical_name": "ascospore wall (1->3)-beta-D-glucan metabolic process", "definition": "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores. [GOC:mah]"}
{"concept_id": "C2612515", "aliases": ["cell wall beta-glucan biosynthesis", "cell wall beta-glucan formation", "cell wall beta-glucan synthesis", "cell wall beta-glucan anabolism"], "types": ["T044"], "canonical_name": "cell wall beta-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells. [GOC:mah]"}
{"concept_id": "C2612516", "aliases": ["cell wall beta-1,3-glucan synthesis", "cell wall 1,3-beta-glucan biosynthesis", "cell wall 1,3-beta-glucan synthesis", "cell wall 1,3-beta-D-glucan biosynthetic process", "cell wall beta-1,3-glucan formation", "cell wall 1,3-beta-glucan biosynthetic process", "cell wall beta-1,3-glucan biosynthetic process", "cell wall 1,3-beta-glucan formation", "cell wall beta-1,3-glucan biosynthesis", "cell wall 1,3-beta-glucan anabolism", "cell wall beta-1,3-glucan anabolism"], "types": ["T044"], "canonical_name": "cell wall (1->3)-beta-D-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells. [GOC:mah]"}
{"concept_id": "C2612517", "aliases": ["ascospore wall beta-glucan biosynthesis", "ascospore wall beta-glucan anabolism", "ascospore wall beta-glucan formation", "ascospore wall beta-glucan synthesis"], "types": ["T044"], "canonical_name": "ascospore wall beta-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores. [GOC:mah]"}
{"concept_id": "C2612518", "aliases": ["ascospore wall 1,3-beta-glucan formation", "ascospore wall beta-1,3-glucan biosynthesis", "ascospore wall 1,3-beta-glucan anabolism", "ascospore wall 1,3-beta-glucan biosynthesis", "ascospore wall 1,3-beta-D-glucan biosynthetic process", "ascospore wall 1,3-beta-glucan synthesis", "ascospore wall beta-1,3-glucan biosynthetic process", "ascospore wall 1,3-beta-glucan biosynthetic process", "ascospore wall beta-1,3-glucan formation", "ascospore wall beta-1,3-glucan synthesis", "ascospore wall beta-1,3-glucan anabolism"], "types": ["T044"], "canonical_name": "ascospore wall (1->3)-beta-D-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores. [GOC:mah]"}
{"concept_id": "C2612519", "aliases": ["tRNA 3'-end cleavage, endonucleolytic", "endonucleolytic tRNA 3'-trailer cleavage", "endonucleolytic tRNA 3'-end cleavage"], "types": ["T045"], "canonical_name": "tRNA 3'-trailer cleavage, endonucleolytic", "definition": "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. [GOC:mah]"}
{"concept_id": "C2612521", "aliases": ["exonucleolytic tRNA 3'-end cleavage", "exonucleolytic tRNA 3'-trailer cleavage", "tRNA 3'-end cleavage, exonucleolytic"], "types": ["T045"], "canonical_name": "tRNA 3'-trailer cleavage, exonucleolytic", "definition": "Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. [GOC:mah]"}
{"concept_id": "C2612522", "aliases": ["2,3-bisphospho-D-glycerate 3-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "bisphosphoglycerate 3-phosphatase activity", "definition": "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate. [EC:3.1.3.80, GOC:mah, PMID:18413611]"}
{"concept_id": "C2612523", "aliases": ["urate formation", "urate anabolism", "urate synthesis", "uric acid biosynthetic process", "urate biosynthesis"], "types": ["T044"], "canonical_name": "urate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine. [GOC:mah]"}
{"concept_id": "C2612525", "aliases": ["cotranslational protein amino acid acetylation", "co-translational protein amino acid acetylation"], "types": ["T044"], "canonical_name": "co-translational protein acetylation", "definition": "The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome. [GOC:mah]"}
{"concept_id": "C2612526", "aliases": ["post-translational protein amino acid acetylation", "posttranslational protein amino acid acetylation"], "types": ["T044"], "canonical_name": "post-translational protein acetylation", "definition": "The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome. [GOC:mah]"}
{"concept_id": "C2612527", "aliases": [], "types": ["T026"], "canonical_name": "aleurone grain lumen", "definition": "The volume enclosed by the membrane of an aleurone grain. [GOC:rph]"}
{"concept_id": "C2612528", "aliases": ["autophagic vacuole lumen"], "types": ["T026"], "canonical_name": "autophagosome lumen", "definition": "The volume enclosed within the autophagosome double-membrane. [GOC:autophagy, GOC:rph]"}
{"concept_id": "C2612529", "aliases": ["Vps55/Vps68 complex location"], "types": ["T026"], "canonical_name": "Vps55/Vps68 complex", "definition": "A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins. [PMID:18216282]"}
{"concept_id": "C2612530", "aliases": [], "types": ["T026"], "canonical_name": "etioplast envelope", "definition": "The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. [GOC:mah]"}
{"concept_id": "C2612531", "aliases": [], "types": ["T026"], "canonical_name": "etioplast membrane", "definition": "Either of the lipid bilayers that surround a etioplast and form the etioplast envelope. [GOC:rph]"}
{"concept_id": "C2612532", "aliases": ["3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'", "definition": "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612533", "aliases": ["5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'", "definition": "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction. [GOC:krc, GOC:mah]"}
{"concept_id": "C2612534", "aliases": [], "types": ["T042"], "canonical_name": "tectobulbar tract morphogenesis", "definition": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain. [GOC:dsf, PMID:15065115, PMID:17507550, PMID:8038988]"}
{"concept_id": "C2612535", "aliases": ["oleosome outer lipid monolayer", "spherosome outer lipid monolayer", "oil body outer lipid monolayer", "lipid storage body surface lipid monolayer"], "types": ["T026"], "canonical_name": "monolayer-surrounded lipid storage body outer lipid monolayer", "definition": "The single layer of phopholipids surrounding a lipid storage body. [GOC:rph]"}
{"concept_id": "C2612536", "aliases": [], "types": ["T026"], "canonical_name": "lipid droplet outer lipid monolayer"}
{"concept_id": "C2612537", "aliases": ["AP6A hydrolase activity", "AP-6-A hydrolase activity", "AP(6)A hydrolase activity", "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity"], "types": ["T044"], "canonical_name": "bis(5'-adenosyl)-hexaphosphatase activity", "definition": "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate. [PMID:10085096, PMID:9450008, RHEA:32047]"}
{"concept_id": "C2612538", "aliases": ["AP5A hydrolase activity", "Ap5a pyrophosphohydrolase activity", "diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity", "AP-5-A hydrolase activity", "AP(5)A hydrolase activity"], "types": ["T044"], "canonical_name": "bis(5'-adenosyl)-pentaphosphatase activity", "definition": "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate. [PMID:10085096, PMID:9450008]"}
{"concept_id": "C2612539", "aliases": [], "types": ["T044"], "canonical_name": "steroid esterification", "definition": "A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol). [GOC:BHF, GOC:mah, GOC:pde, GOC:rl]"}
{"concept_id": "C2612540", "aliases": [], "types": ["T044"], "canonical_name": "sterol esterification", "definition": "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol). [GOC:BHF, GOC:mah, GOC:pde, GOC:rl]"}
{"concept_id": "C2612541", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol esterification", "definition": "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. [GOC:BHF, GOC:mah, GOC:pde, GOC:rl]"}
{"concept_id": "C2612542", "aliases": [], "types": ["T043"], "canonical_name": "glycoprotein transport", "definition": "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:BHF, GOC:mah, GOC:rl]"}
{"concept_id": "C2612544", "aliases": [], "types": ["T044"], "canonical_name": "lipoprotein amino acid oxidation", "definition": "The modification of a lipoprotein by oxidation of one or more amino acids in the protein. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612545", "aliases": [], "types": ["T044"], "canonical_name": "lipoprotein lipid oxidation", "definition": "The modification of a lipoprotein by oxidation of the lipid group. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612546", "aliases": [], "types": ["T044"], "definition": "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. [GOC:BHF, GOC:mah]", "canonical_name": "lipid oxidation"}
{"concept_id": "C2612547", "aliases": [], "types": ["T044"], "canonical_name": "plasma lipoprotein particle oxidation", "definition": "The modification of a lipid or protein within a plasma lipoprotein particle by oxidation of the lipid or one or more amino acids. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612548", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lipoprotein oxidation", "definition": "Any process that modulates the frequency, rate or extent of lipoprotein oxidation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612549", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lipoprotein oxidation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612550", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lipoprotein oxidation"}
{"concept_id": "C2612552", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of plasma lipoprotein particle oxidation"}
{"concept_id": "C2612553", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of plasma lipoprotein oxidation"}
{"concept_id": "C2612554", "aliases": ["cell spreading during cell substrate adhesion", "substrate adhesion dependent cell spreading"], "types": ["T043"], "canonical_name": "substrate adhesion-dependent cell spreading", "definition": "The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. [GOC:mah, GOC:pf, PMID:17050732]"}
{"concept_id": "C2612555", "aliases": ["VLDL clearance"], "types": ["T043"], "canonical_name": "very-low-density lipoprotein particle clearance", "definition": "The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2612558", "aliases": ["ubiquitin-ubiquitin ligase activity"], "types": ["T044"], "definition": "Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]", "canonical_name": "E4"}
{"concept_id": "C2612559", "aliases": [], "types": ["T044"], "canonical_name": "dynactin binding", "definition": "Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612560", "aliases": [], "types": ["T043"], "canonical_name": "microtubule anchoring", "definition": "Any process in which a microtubule is maintained in a specific location in a cell. [GOC:mah]"}
{"concept_id": "C2612561", "aliases": [], "types": ["T043"], "canonical_name": "microtubule anchoring at centrosome", "definition": "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612562", "aliases": ["Nan1p-containing subcomplex of 90S preribosome location", "t-UTP complex location", "Nan1p-containing subcomplex of 90S preribosome"], "types": ["T026"], "canonical_name": "t-UTP complex", "definition": "A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p. [GOC:krc, GOC:mah, GOC:vw, PMID:17515605]"}
{"concept_id": "C2612563", "aliases": ["Rrp7p-containing subcomplex of 90S preribosome location", "UTP-C complex location", "Rrp7p-containing subcomplex of 90S preribosome"], "types": ["T026"], "canonical_name": "UTP-C complex", "definition": "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p. [GOC:mah, PMID:17515605]"}
{"concept_id": "C2612564", "aliases": ["Mpp10 complex location"], "types": ["T026"], "canonical_name": "Mpp10 complex", "definition": "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p. [GOC:mah, PMID:17515605]"}
{"concept_id": "C2612565", "aliases": ["ATP-dependent 3'-5' RNA helicase activity", "3' to 5' RNA helicase activity", "ATP-dependent 3' to 5' RNA helicase activity"], "types": ["T045"], "canonical_name": "3'-5' RNA helicase activity", "definition": "Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis. [GOC:jp]"}
{"concept_id": "C2612567", "aliases": ["uropod formation"], "types": ["T043"], "canonical_name": "uropod assembly", "definition": "The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane. [GOC:mah]"}
{"concept_id": "C2612568", "aliases": [], "types": ["T043"], "canonical_name": "uropod retraction", "definition": "The process in which a uropod detaches from the cell substrate and retracts the rear of a migrating cell. [GOC:mah, PMID:10704379]"}
{"concept_id": "C2612569", "aliases": ["small subunit processome assembly", "SSU processome assembly"], "types": ["T044"], "canonical_name": "small-subunit processome assembly", "definition": "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome. [GOC:mah]"}
{"concept_id": "C2612570", "aliases": [], "types": ["T044"], "canonical_name": "90S preribosome assembly", "definition": "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions. [GOC:krc, GOC:mah, GOC:tb]"}
{"concept_id": "C2612571", "aliases": ["Bardet-Biedl syndrome complex", "Bardet-Biedl syndrome complex location"], "types": ["T026"], "canonical_name": "BBSome", "definition": "A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B. [GOC:BHF, GOC:cilia, PMID:15231740, PMID:17574030, PMID:26498262]"}
{"concept_id": "C2612572", "aliases": [], "types": ["T043"], "canonical_name": "response to carbon monoxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus. [GOC:ecd]"}
{"concept_id": "C2612573", "aliases": [], "types": ["T026"], "canonical_name": "chromaffin granule lumen", "definition": "The volume enclosed by the membrane of a chromaffin granule. [GOC:rph]"}
{"concept_id": "C2612574", "aliases": [], "types": ["T026"], "canonical_name": "esterosome lumen", "definition": "The volume enclosed by the membrane of an esterosome. [GOC:rph]"}
{"concept_id": "C2612575", "aliases": [], "types": ["T026"], "canonical_name": "glycosome lumen", "definition": "The volume enclosed by the membrane of a glycosome. [GOC:rph]"}
{"concept_id": "C2612576", "aliases": [], "types": ["T026"], "canonical_name": "Golgi stack lumen", "definition": "The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex. [GOC:mah]"}
{"concept_id": "C2612577", "aliases": [], "types": ["T045"], "canonical_name": "ncRNA processing", "definition": "Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. [GOC:mah, PMID:27573892]"}
{"concept_id": "C2612578", "aliases": ["ncRNA 5' end processing"], "types": ["T045"], "canonical_name": "ncRNA 5'-end processing", "definition": "Any process involved in forming the mature 5' end of a non-coding RNA molecule. [GOC:mah]"}
{"concept_id": "C2612579", "aliases": ["snRNA 3' end processing"], "types": ["T045"], "canonical_name": "snRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of an snRNA molecule. [GOC:mah]"}
{"concept_id": "C2612580", "aliases": ["U1 snRNA 3' end processing"], "types": ["T045"], "canonical_name": "U1 snRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of a U1 snRNA molecule. [GOC:mah]"}
{"concept_id": "C2612581", "aliases": ["U2 snRNA 3' end processing"], "types": ["T045"], "canonical_name": "U2 snRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of a U2 snRNA molecule. [GOC:mah]"}
{"concept_id": "C2612582", "aliases": ["U4 snRNA 3' end processing"], "types": ["T045"], "canonical_name": "U4 snRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of a U4 snRNA molecule. [GOC:mah]"}
{"concept_id": "C2612583", "aliases": ["U5 snRNA 3' end processing"], "types": ["T045"], "canonical_name": "U5 snRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of a U5 snRNA molecule. [GOC:mah]"}
{"concept_id": "C2612584", "aliases": ["U6 snRNA 3' end processing"], "types": ["T045"], "canonical_name": "U6 snRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of a U6 snRNA molecule. [GOC:mah]"}
{"concept_id": "C2612585", "aliases": ["phosphatidylglycerol catabolism", "phosphatidylglycerol degradation", "phosphatidylglycerol breakdown"], "types": ["T044"], "canonical_name": "phosphatidylglycerol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. [GOC:mah]"}
{"concept_id": "C2612586", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylglycerol phospholipase C activity", "definition": "Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate. [GOC:mah, PMID:18434318]"}
{"concept_id": "C2612587", "aliases": ["lipophosphodiesterase I activity", "phospholipase C, acting on phosphatidylcholine", "phosphatidylcholine cholinephosphohydrolase activity"], "types": ["T044"], "canonical_name": "phosphatidylcholine phospholipase C activity", "definition": "Catalysis of the reaction: phosphatidylcholine + H2O = 1,2-diacylglycerol + a choline phosphate. [EC:3.1.4.3, GOC:mah]"}
{"concept_id": "C2612588", "aliases": [], "types": ["T044"], "canonical_name": "Clostridium oedematiens beta- and gamma-toxins activity"}
{"concept_id": "C2612589", "aliases": [], "types": ["T044"], "canonical_name": "Clostridium welchii alpha-toxin activity"}
{"concept_id": "C2612590", "aliases": [], "types": ["T044"], "canonical_name": "heat-labile hemolysin"}
{"concept_id": "C2612591", "aliases": [], "types": ["T044"], "canonical_name": "chondroitin sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate. [EC:2.8.2.17, EC:2.8.2.5, GOC:mah]"}
{"concept_id": "C2612592", "aliases": ["chondroitin 2-O-sulphotransferase activity", "chondroitin 2-sulfotransferase activity"], "types": ["T044"], "canonical_name": "chondroitin 2-O-sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues. [PMID:17227754]"}
{"concept_id": "C2612593", "aliases": [], "types": ["T044"], "canonical_name": "heparan sulfate sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. [GOC:mah]"}
{"concept_id": "C2612594", "aliases": ["raffinose catabolism", "raffinose degradation", "raffinose breakdown"], "types": ["T044"], "canonical_name": "raffinose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. [GOC:mah]"}
{"concept_id": "C2612595", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate. [GOC:pf]"}
{"concept_id": "C2612596", "aliases": ["vacuolar membrane transport"], "types": ["T043"], "canonical_name": "vacuolar transmembrane transport", "definition": "The process in which a solute is transported from one side of the vacuolar membrane to the other. [GOC:mah]"}
{"concept_id": "C2612597", "aliases": ["vacuolar amino acid membrane transport"], "types": ["T043"], "canonical_name": "vacuolar amino acid transmembrane transport", "definition": "The process in which an amino acid is transported from one side of the vacuolar membrane to the other. [GOC:mah]"}
{"concept_id": "C2612600", "aliases": [], "types": ["T043"], "canonical_name": "basic amino acid transmembrane import into vacuole", "definition": "The directed movement of basic amino acids into the vacuole across the vacuolar membrane. [GOC:mah]"}
{"concept_id": "C2612602", "aliases": [], "types": ["T026"], "canonical_name": "hydrogenosome lumen", "definition": "The volume enclosed by the hydrogenosome membrane. [GOC:rph]"}
{"concept_id": "C2612603", "aliases": [], "types": ["T026"], "canonical_name": "melanosome lumen", "definition": "The volume enclosed by the melanosome membrane. [GOC:rph]"}
{"concept_id": "C2612604", "aliases": [], "types": ["T026"], "canonical_name": "microneme lumen", "definition": "The volume enclosed by the microneme membrane. [GOC:rph]"}
{"concept_id": "C2612605", "aliases": [], "types": ["T026"], "canonical_name": "protein storage vacuole lumen", "definition": "The volume enclosed by the protein storage vacuole membrane. [GOC:rph]"}
{"concept_id": "C2612606", "aliases": ["MVB membrane disassembly"], "types": ["T043"], "canonical_name": "multivesicular body membrane disassembly", "definition": "The controlled breakdown of the membranes of multivesicular bodies. [GOC:rb]"}
{"concept_id": "C2612607", "aliases": ["protein localisation to phagophore assembly site", "protein localization to PAS", "protein localization to pre-autophagosomal structure"], "types": ["T043"], "canonical_name": "protein localization to phagophore assembly site", "definition": "Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS). [GOC:rb]"}
{"concept_id": "C2612608", "aliases": ["post-Golgi endosome to Golgi transport", "PGE to Golgi transport"], "types": ["T043"], "canonical_name": "early endosome to Golgi transport", "definition": "The directed movement of substances from early endosomes to the Golgi. [GOC:rb]"}
{"concept_id": "C2612609", "aliases": ["prevacuolar endosome to Golgi transport", "PVE to Golgi transport"], "types": ["T043"], "canonical_name": "late endosome to Golgi transport", "definition": "The directed movement of substances from late endosomes to the Golgi. [GOC:rb]"}
{"concept_id": "C2612610", "aliases": [], "types": ["T043"], "canonical_name": "rDNA separation"}
{"concept_id": "C2612611", "aliases": ["protein localisation to kinetochore"], "types": ["T043"], "canonical_name": "protein localization to kinetochore", "definition": "Any process in which a protein is transported to, or maintained at, the kinetochore. [GOC:mah]"}
{"concept_id": "C2612612", "aliases": [], "types": ["T043"], "canonical_name": "condensin localization to kinetochore"}
{"concept_id": "C2612613", "aliases": ["protein localisation to chromosome"], "types": ["T043"], "canonical_name": "protein localization to chromosome", "definition": "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. [GOC:mah]"}
{"concept_id": "C2612614", "aliases": [], "types": ["T043"], "canonical_name": "condensin localization to chromosome"}
{"concept_id": "C2612615", "aliases": ["protein localisation to nucleolar rDNA repeats"], "types": ["T043"], "canonical_name": "protein localization to nucleolar rDNA repeats", "definition": "Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus. [GOC:mah]"}
{"concept_id": "C2612616", "aliases": [], "types": ["T043"], "canonical_name": "condensin localization to nucleolar rDNA repeats"}
{"concept_id": "C2612617", "aliases": ["protein localization in nucleus", "protein localisation to nucleus", "protein localization in cell nucleus"], "types": ["T043"], "canonical_name": "protein localization to nucleus", "definition": "A process in which a protein transports or maintains the localization of another protein to the nucleus. [GOC:ecd]"}
{"concept_id": "C2612618", "aliases": ["chromosome, centromeric core region"], "types": ["T026"], "canonical_name": "chromosome, centromeric core domain", "definition": "The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it. [GOC:mah, GOC:vw]"}
{"concept_id": "C2612619", "aliases": [], "types": ["T026"], "canonical_name": "chromosome, centric core region"}
{"concept_id": "C2612620", "aliases": [], "types": ["T026"], "canonical_name": "chromosome, centromeric outer repeat region", "definition": "The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it. [GOC:mah, GOC:vw]"}
{"concept_id": "C2612621", "aliases": ["chromosome, centric outer repeat region"], "types": ["T026"], "canonical_name": "chromosome, centric outer repeat region"}
{"concept_id": "C2612622", "aliases": ["centromere assembly", "chromosome, centromeric region assembly", "centromere organization"], "types": ["T045"], "canonical_name": "centromere complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. [GOC:mah, GOC:vw]"}
{"concept_id": "C2612624", "aliases": [], "types": ["T043"], "canonical_name": "centromere separation", "definition": "The cell cycle process in which centromeres are physically detached from each other during chromosome separation. [GOC:mah]"}
{"concept_id": "C2612625", "aliases": [], "types": ["T045"], "canonical_name": "U3 snoRNA binding", "definition": "Binding to a U3 small nucleolar RNA. [GOC:mah]"}
{"concept_id": "C2612626", "aliases": [], "types": ["T045"], "canonical_name": "box C/D snoRNA binding"}
{"concept_id": "C2612627", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA snoRNA binding", "definition": "Binding to a box H/ACA small nucleolar RNA. [GOC:mah]"}
{"concept_id": "C2612628", "aliases": ["mtUPR"], "types": ["T044"], "canonical_name": "mitochondrial unfolded protein response", "definition": "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins. [GOC:mah, PMID:17849004]"}
{"concept_id": "C2612629", "aliases": ["PSG"], "types": ["T026"], "definition": "An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state. [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036]", "canonical_name": "proteasome storage granule"}
{"concept_id": "C2612630", "aliases": [], "types": ["T043"], "canonical_name": "response to vitamin B6", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. [GOC:mah, GOC:rph]"}
{"concept_id": "C2612631", "aliases": [], "types": ["T043"], "definition": "The selective autophagy process in which cells degrade mature ribosomes under conditions of starvation. [GOC:autophagy, PMID:18391941]", "canonical_name": "ribophagy"}
{"concept_id": "C2612632", "aliases": ["RNA cap binding complex location"], "types": ["T026"], "canonical_name": "RNA cap binding complex", "definition": "Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. [GOC:mah]"}
{"concept_id": "C2612633", "aliases": ["cytoplasmic RNA cap binding complex location"], "types": ["T026"], "canonical_name": "cytoplasmic RNA cap binding complex", "definition": "A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA. [PMID:16405910]"}
{"concept_id": "C2612634", "aliases": [], "types": ["T044"], "canonical_name": "2-naphthaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+. [UM-BBD_reactionID:r0772]"}
{"concept_id": "C2612635", "aliases": [], "types": ["T044"], "canonical_name": "1-naphthoic acid dioxygenase activity", "definition": "Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+. [UM-BBD_reactionID:r0773]"}
{"concept_id": "C2612636", "aliases": [], "types": ["T044"], "canonical_name": "cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity", "definition": "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-. [UM-BBD_reactionID:r0774]"}
{"concept_id": "C2612637", "aliases": [], "types": ["T044"], "canonical_name": "3-formylsalicylate oxidase activity", "definition": "Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide. [UM-BBD_reactionID:r0777]"}
{"concept_id": "C2612638", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyisophthalate decarboxylase activity", "definition": "Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2. [UM-BBD_reactionID:r0776]"}
{"concept_id": "C2612639", "aliases": [], "types": ["T044"], "canonical_name": "1-naphthaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+. [UM-BBD_reactionID:r0787]"}
{"concept_id": "C2612640", "aliases": [], "types": ["T044"], "canonical_name": "2-methylnaphthalene hydroxylase activity", "definition": "Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O. [UM-BBD_reactionID:r0788]"}
{"concept_id": "C2612641", "aliases": [], "types": ["T044"], "canonical_name": "1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity", "definition": "Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene. [UM-BBD_reactionID:r0790]"}
{"concept_id": "C2612642", "aliases": [], "types": ["T044"], "canonical_name": "2-carboxy-2-hydroxy-8-carboxychromene isomerase activity", "definition": "Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate. [UM-BBD_reactionID:r0791]"}
{"concept_id": "C2612643", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate. [PMID:7710320]"}
{"concept_id": "C2612644", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxymethylsalicyaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+. [UM-BBD_reactionID:r0767]"}
{"concept_id": "C2612645", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde. [PMID:8042906]"}
{"concept_id": "C2612646", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity", "definition": "Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate. [UM-BBD_reactionID:r0765]"}
{"concept_id": "C2612647", "aliases": [], "types": ["T044"], "canonical_name": "1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity", "definition": "Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate. [UM-BBD_reactionID:r0764]"}
{"concept_id": "C2612648", "aliases": [], "types": ["T044"], "canonical_name": "1-methylnaphthalene hydroxylase activity", "definition": "Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O. [UM-BBD_reactionID:r0795]"}
{"concept_id": "C2612649", "aliases": [], "types": ["T044"], "canonical_name": "1,2-dihydroxy-8-methylnaphthalene dioxygenase activity", "definition": "Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+. [UM-BBD_reactionID:r0781]"}
{"concept_id": "C2612650", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-8-methylchromene-2-carboxylate isomerase activity", "definition": "Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate. [UM-BBD_reactionID:r0782]"}
{"concept_id": "C2612651", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde. [PMID:8042906]"}
{"concept_id": "C2612652", "aliases": [], "types": ["T044"], "canonical_name": "3-methylsalicylaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+. [UM-BBD_reactionID:r0784]"}
{"concept_id": "C2612653", "aliases": [], "types": ["T044"], "canonical_name": "3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity", "definition": "Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr. [UM-BBD_reactionID:r0821]"}
{"concept_id": "C2612654", "aliases": [], "types": ["T044"], "canonical_name": "3-monobromobisphenol A reductive dehalogenase activity", "definition": "Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr. [UM-BBD_reactionID:r0824]"}
{"concept_id": "C2612655", "aliases": [], "types": ["T044"], "canonical_name": "dimethylarsinite methyltransferase activity", "definition": "Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH. [UM-BBD_reactionID:r0806]"}
{"concept_id": "C2612656", "aliases": [], "types": ["T044"], "canonical_name": "trimethylarsine oxidase activity", "definition": "Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O. [UM-BBD_reactionID:r0807]"}
{"concept_id": "C2612657", "aliases": [], "types": ["T044"], "canonical_name": "5-aminosalicylate dioxygenase activity", "definition": "Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate. [UM-BBD_reactionID:r0809]"}
{"concept_id": "C2612658", "aliases": [], "types": ["T044"], "canonical_name": "trans-ACOHDA hydrolase activity", "definition": "Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3. [UM-BBD_reactionID:r0810]"}
{"concept_id": "C2612659", "aliases": [], "types": ["T044"], "canonical_name": "fumarylpyruvate hydrolase activity", "definition": "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+. [UM-BBD_reactionID:r0811]"}
{"concept_id": "C2612660", "aliases": [], "types": ["T044"], "canonical_name": "2,4-dichloroaniline reductive dehalogenase activity", "definition": "Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl. [UM-BBD_reactionID:r0819]"}
{"concept_id": "C2612661", "aliases": [], "types": ["T044"], "canonical_name": "N-cyclopropylmelamine deaminase activity", "definition": "Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3. [UM-BBD_reactionID:r0825]"}
{"concept_id": "C2612662", "aliases": [], "types": ["T044"], "canonical_name": "N-cyclopropylammeline deaminase activity", "definition": "Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3. [UM-BBD_reactionID:r0826]"}
{"concept_id": "C2612663", "aliases": [], "types": ["T044"], "canonical_name": "N-cyclopropylammelide alkylamino hydrolase activity", "definition": "Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid. [UM-BBD_reactionID:r0827]"}
{"concept_id": "C2612664", "aliases": [], "types": ["T044"], "canonical_name": "dimethylarsinate reductase activity", "definition": "Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O. [UM-BBD_reactionID:r0838]"}
{"concept_id": "C2612665", "aliases": ["mitochondrial cytochrome bc(1) complex assembly"], "types": ["T044"], "canonical_name": "mitochondrial respiratory chain complex III assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane. [GOC:dgf, GOC:mcc]"}
{"concept_id": "C2612666", "aliases": [], "types": ["T044"], "canonical_name": "respiratory chain complex II assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. [GOC:dgf]"}
{"concept_id": "C2612667", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial respiratory chain complex II assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane. [GOC:dgf]"}
{"concept_id": "C2612668", "aliases": [], "types": ["T044"], "canonical_name": "3,3',5-tribromobisphenol A reductive dehalogenase activity", "definition": "Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr. [UM-BBD_reactionID:r0842]"}
{"concept_id": "C2612669", "aliases": [], "types": ["T044"], "canonical_name": "3,3'-dibromobisphenol A reductive dehalogenase activity", "definition": "Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr. [UM-BBD_reactionID:r0844]"}
{"concept_id": "C2612670", "aliases": [], "types": ["T044"], "canonical_name": "nitrobenzoate nitroreductase activity", "definition": "Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+. [UM-BBD_reactionID:r0849]"}
{"concept_id": "C2612671", "aliases": [], "types": ["T044"], "canonical_name": "o-hydroxylaminobenzoate nitroreductase activity"}
{"concept_id": "C2612672", "aliases": [], "types": ["T044"], "canonical_name": "technetium (VII) reductase activity", "definition": "Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-. [UM-BBD_reactionID:r0859]"}
{"concept_id": "C2612673", "aliases": [], "types": ["T044"], "canonical_name": "bisphenol A hydroxylase B activity", "definition": "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O. [UM-BBD_reactionID:r0860]"}
{"concept_id": "C2612674", "aliases": [], "types": ["T044"], "canonical_name": "bisphenol A hydroxylase A activity", "definition": "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O. [UM-BBD_reactionID:r0861]"}
{"concept_id": "C2612675", "aliases": [], "types": ["T044"], "canonical_name": "1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity", "definition": "Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O. [UM-BBD_reactionID:r0862]"}
{"concept_id": "C2612676", "aliases": [], "types": ["T044"], "canonical_name": "2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity", "definition": "Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O. [UM-BBD_reactionID:r0864]"}
{"concept_id": "C2612677", "aliases": [], "types": ["T044"], "canonical_name": "2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity", "definition": "Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-. [UM-BBD_reactionID:r0867]"}
{"concept_id": "C2612678", "aliases": [], "types": ["T044"], "canonical_name": "4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity", "definition": "Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-. [UM-BBD_reactionID:r0866]"}
{"concept_id": "C2612679", "aliases": [], "types": ["T044"], "canonical_name": "1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity", "definition": "Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol. [UM-BBD_reactionID:r0872]"}
{"concept_id": "C2612681", "aliases": [], "types": ["T044"], "canonical_name": "chromate reductase activity", "definition": "Catalysis of the reaction: chromate = chromium (III). [UM-BBD_reactionID:r0884]"}
{"concept_id": "C2612682", "aliases": [], "types": ["T044"], "canonical_name": "isoproturon dimethylaminedehydrogenase activity", "definition": "Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-. [UM-BBD_reactionID:r0892]"}
{"concept_id": "C2612683", "aliases": [], "types": ["T044"], "canonical_name": "monodemethylisoproturon dehydrogenase activity", "definition": "Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-. [UM-BBD_reactionID:r0893]"}
{"concept_id": "C2612684", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymonomethylisoproturon dimethylaminedehydrogenase activity", "definition": "Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-. [UM-BBD_reactionID:r0894]"}
{"concept_id": "C2612685", "aliases": [], "types": ["T044"], "canonical_name": "4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity", "definition": "Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid. [UM-BBD_reactionID:r0895]"}
{"concept_id": "C2612686", "aliases": [], "types": ["T044"], "canonical_name": "monodemethylisoproturon dimethylaminedehydrogenase activity", "definition": "Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-. [UM-BBD_reactionID:r0897]"}
{"concept_id": "C2612687", "aliases": [], "types": ["T044"], "canonical_name": "didemethylisoproturon amidohydrolase activity", "definition": "Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline. [UM-BBD_reactionID:r0898]"}
{"concept_id": "C2612688", "aliases": [], "types": ["T044"], "canonical_name": "didemethylisoproturon dehydrogenase activity", "definition": "Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-. [UM-BBD_reactionID:r0899]"}
{"concept_id": "C2612689", "aliases": [], "types": ["T044"], "canonical_name": "4-isopropylaniline dehydrogenase activity", "definition": "Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-. [UM-BBD_reactionID:r0901]"}
{"concept_id": "C2612690", "aliases": [], "types": ["T044"], "canonical_name": "N-isopropylacetanilide amidohydrolase activity", "definition": "Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate. [UM-BBD_reactionID:r0913]"}
{"concept_id": "C2612691", "aliases": [], "types": ["T044"], "canonical_name": "N-isopropylacetaniline monooxygenase activity", "definition": "Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone. [UM-BBD_reactionID:r0914]"}
{"concept_id": "C2612692", "aliases": [], "types": ["T044"], "canonical_name": "limonene 8-hydratase activity", "definition": "Catalysis of the reaction: limonene + H2O = alpha-terpineol. [UM-BBD_reactionID:r0916]"}
{"concept_id": "C2612693", "aliases": [], "types": ["T044"], "canonical_name": "(1-methylpentyl)succinate synthase activity", "definition": "Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate. [UM-BBD_reactionID:r0920]"}
{"concept_id": "C2612694", "aliases": [], "types": ["T044"], "canonical_name": "4-methyloctanoyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-. [UM-BBD_reactionID:r0924]"}
{"concept_id": "C2612695", "aliases": [], "types": ["T044"], "canonical_name": "4-methyloct-2-enoyl-CoA hydratase activity", "definition": "Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA. [UM-BBD_reactionID:r0925]"}
{"concept_id": "C2612696", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-. [UM-BBD_reactionID:r0926]"}
{"concept_id": "C2612697", "aliases": [], "types": ["T045"], "canonical_name": "21U-RNA binding", "definition": "Binding to a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. [GOC:kmv]"}
{"concept_id": "C2612698", "aliases": ["Piwi-associated RNA binding"], "types": ["T045"], "canonical_name": "piRNA binding", "definition": "Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. [GOC:kmv]"}
{"concept_id": "C2612699", "aliases": ["21U-RNA metabolism"], "types": ["T045"], "canonical_name": "21U-RNA metabolic process", "definition": "The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. [GOC:kmv]"}
{"concept_id": "C2612700", "aliases": ["21U-RNA degradation", "21U-RNA catabolism", "21U-RNA breakdown"], "types": ["T045"], "canonical_name": "21U-RNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. [GOC:kmv]"}
{"concept_id": "C2612701", "aliases": ["piRNA metabolism", "Piwi-associated RNA metabolic process"], "types": ["T045"], "canonical_name": "piRNA metabolic process", "definition": "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. [GOC:kmv]"}
{"concept_id": "C2612702", "aliases": ["piRNA degradation", "piRNA breakdown", "piRNA catabolism", "Piwi-associated RNA catabolic process"], "types": ["T045"], "canonical_name": "piRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. [GOC:kmv]"}
{"concept_id": "C2612703", "aliases": ["4-hydroxyproline transport"], "types": ["T043"], "canonical_name": "hydroxyproline transport", "definition": "The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah, PMID:14502423]"}
{"concept_id": "C2612704", "aliases": [], "types": ["T043"], "canonical_name": "L-hydroxyproline transport"}
{"concept_id": "C2612705", "aliases": [], "types": ["T044"], "canonical_name": "L-hydroxyproline transmembrane transporter activity", "definition": "Enables the transfer of L-hydroxyproline from one side of a membrane to the other. [GOC:mah, PMID:14502423]"}
{"concept_id": "C2612706", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxyproline transmembrane transporter activity"}
{"concept_id": "C2612707", "aliases": [], "types": ["T026"], "canonical_name": "rhoptry lumen", "definition": "The volume enclosed by the rhoptry membrane. [GOC:rph, PMID:17997128]"}
{"concept_id": "C2612708", "aliases": [], "types": ["T026"], "canonical_name": "synaptic vesicle lumen", "definition": "The volume enclosed by the synaptic vesicle membrane. [GOC:rph]"}
{"concept_id": "C2612709", "aliases": ["phosphatidyl-inositol-bisphosphate phosphatase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol bisphosphate phosphatase activity", "definition": "Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate. [GOC:mah]"}
{"concept_id": "C2612710", "aliases": [], "types": ["T044"], "canonical_name": "diphosphoinositide phosphatase activity"}
{"concept_id": "C2612711", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol trisphosphate phosphatase activity", "definition": "Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate. [GOC:mah]"}
{"concept_id": "C2612712", "aliases": ["polyphosphoinositol lipid 5-phosphatase activity", "phosphoinositide 5-phosphatase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphate 5-phosphatase activity", "definition": "Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. [GOC:elh]"}
{"concept_id": "C2612713", "aliases": ["phosphoinositide 4-phosphatase activity", "PtdIns4P-phosphatase activity", "PI(4)P-phosphatase activity", "PI4P-phosphatase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphate 4-phosphatase activity", "definition": "Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. [GOC:mah]"}
{"concept_id": "C2612714", "aliases": ["1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity", "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. [GOC:mah]"}
{"concept_id": "C2612715", "aliases": [], "types": ["T044"], "canonical_name": "phosphothreonine lyase activity", "definition": "Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product. [PMID:17303758, PMID:18084305]"}
{"concept_id": "C2612716", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to oxidative stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah]"}
{"concept_id": "C2612717", "aliases": [], "types": ["T044"], "canonical_name": "oxoglutarate dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H. [EC:1.2.1.52, GOC:mah]"}
{"concept_id": "C2612718", "aliases": [], "types": ["T044"], "canonical_name": "oxoglutarate dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH. [GOC:mah, RHEA:27786]"}
{"concept_id": "C2612719", "aliases": [], "types": ["T044"], "canonical_name": "pyruvate dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. [GOC:mah]"}
{"concept_id": "C2612720", "aliases": [], "types": ["T044"], "canonical_name": "pyruvate dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH. [GOC:mah, ISBN:0201090910]"}
{"concept_id": "C2612721", "aliases": ["cellular response to heat stress"], "types": ["T039"], "canonical_name": "cellular response to heat", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:mah]"}
{"concept_id": "C2612722", "aliases": [], "types": ["T055"], "canonical_name": "response to hermaphrodite contact", "definition": "The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate. [PMID:18050467, WB_REF:WBPaper00002109]"}
{"concept_id": "C2612723", "aliases": ["turning behavior during mating"], "types": ["T055"], "canonical_name": "turning behavior involved in mating", "definition": "The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. [PMID:18050467, WB_REF:WBPaper00002109]"}
{"concept_id": "C2612724", "aliases": [], "types": ["T055"], "canonical_name": "vulval location", "definition": "Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate. [PMID:18050467]"}
{"concept_id": "C2612725", "aliases": [], "types": ["T055"], "canonical_name": "spicule insertion", "definition": "Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva. [PMID:18050467]"}
{"concept_id": "C2612726", "aliases": ["DNA oligonucleotidase activity"], "types": ["T045"], "canonical_name": "oligodeoxyribonucleotidase activity", "definition": "Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates. [GOC:mah]"}
{"concept_id": "C2612727", "aliases": ["RNA oligonucleotidase activity"], "types": ["T045"], "canonical_name": "oligoribonucleotidase activity", "definition": "Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates. [GOC:mah]"}
{"concept_id": "C2612728", "aliases": ["response to TNF"], "types": ["T043"], "canonical_name": "response to tumor necrosis factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah]"}
{"concept_id": "C2612730", "aliases": ["cellular response to active oxygen species", "cellular response to reactive oxidative species", "cellular response to reactive oxygen intermediate", "cellular response to ROS", "cellular response to ROI", "cellular response to AOS"], "types": ["T043"], "canonical_name": "cellular response to reactive oxygen species", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:mah]"}
{"concept_id": "C2612731", "aliases": ["GCH1 complex location", "GTP cyclohydrolase I complex", "GTP cyclohydrolase I complex location"], "types": ["T026"], "canonical_name": "GCH1 complex", "definition": "A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive. [PMID:16696853]"}
{"concept_id": "C2612732", "aliases": [], "types": ["T039"], "canonical_name": "response to laminar fluid shear stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. [GOC:ecd]"}
{"concept_id": "C2612733", "aliases": ["sapropterin binding", "BH4 binding", "H4biopterin binding"], "types": ["T044"], "canonical_name": "tetrahydrobiopterin binding", "definition": "Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions. [GOC:BHF, GOC:mah, GOC:rl]"}
{"concept_id": "C2612734", "aliases": ["Arg binding"], "types": ["T044"], "canonical_name": "arginine binding", "definition": "Binding to 2-amino-5-(carbamimidamido)pentanoic acid. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2612735", "aliases": [], "types": ["T044"], "canonical_name": "aminopentanoic acid binding"}
{"concept_id": "C2612742", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid elongation, monounsaturated fatty acid", "definition": "Elongation of a fatty acid chain into which one C-C double bond has been introduced. [GOC:mah]"}
{"concept_id": "C2612743", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid elongation, polyunsaturated fatty acid", "definition": "Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced. [GOC:mah]"}
{"concept_id": "C2612744", "aliases": ["de novo NAD biosynthetic process"], "types": ["T044"], "canonical_name": "'de novo' NAD biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. [GOC:imk, PMID:17161604]"}
{"concept_id": "C2612745", "aliases": ["nicotinamide nucleotide anabolism from aspartate", "nicotinamide nucleotide formation from aspartate", "nicotinamide nucleotide biosynthetic process from aspartate", "de novo NAD biosynthetic process from aspartate", "nicotinamide nucleotide synthesis from aspartate"], "types": ["T044"], "canonical_name": "'de novo' NAD biosynthetic process from aspartate", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. [GOC:imk]"}
{"concept_id": "C2612747", "aliases": ["RITS complex localisation", "establishment and maintenance of RITS complex localization"], "types": ["T043"], "canonical_name": "RITS complex localization", "definition": "Any process in which a RITS complex is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C2612748", "aliases": ["attachment of spindle microtubules to spindle pole body", "microtubule anchoring at SPB", "attachment of spindle microtubules to SPB"], "types": ["T043"], "canonical_name": "microtubule anchoring at spindle pole body", "definition": "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end. [GOC:mah, PMID:17486116]"}
{"concept_id": "C2612749", "aliases": ["retinol transporter activity", "vitamin A1 transporter activity"], "types": ["T044"], "canonical_name": "retinol transmembrane transporter activity", "definition": "Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. [GOC:BHF, GOC:mah, GOC:vk]"}
{"concept_id": "C2612750", "aliases": ["vitamin A1 transport"], "types": ["T043"], "canonical_name": "retinol transport", "definition": "The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. [GOC:BHF, GOC:mah, GOC:vk]"}
{"concept_id": "C2612751", "aliases": [], "types": ["T044"], "canonical_name": "glutathione transmembrane transporter activity", "definition": "Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2612752", "aliases": [], "types": ["T043"], "canonical_name": "glutathione transport", "definition": "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2612754", "aliases": [], "types": ["T044"], "canonical_name": "cellular carbohydrate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. [GOC:mah]"}
{"concept_id": "C2612755", "aliases": ["phosphatidylcholine catabolism", "phosphatidylcholine breakdown", "phosphatidylcholine degradation"], "types": ["T044"], "canonical_name": "phosphatidylcholine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:jp]"}
{"concept_id": "C2612756", "aliases": ["L-amino acid efflux permease activity", "L-amino acid export transporter activity"], "types": ["T044"], "canonical_name": "L-amino acid efflux transmembrane transporter activity", "definition": "Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane. [GOC:mah]"}
{"concept_id": "C2612757", "aliases": ["mitochondrial localization by microtubule attachment", "mitochondrial migration by microtubule attachment", "establishment of mitochondrion localisation by microtubule attachment", "mitochondrion migration by microtubule attachment"], "types": ["T043"], "canonical_name": "establishment of mitochondrion localization by microtubule attachment", "definition": "The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization. [GOC:mah, PMID:12972644]"}
{"concept_id": "C2612758", "aliases": ["cellular nitrogen compound metabolism"], "types": ["T040"], "canonical_name": "cellular nitrogen compound metabolic process", "definition": "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. [GOC:mah]"}
{"concept_id": "C2612759", "aliases": ["mitochondrial migration, actin-mediated", "mitochondrial migration along microfilament", "mitochondrion migration along microfilament", "mitochondrion transport along actin filament", "mitochondrial migration along actin filament"], "types": ["T043"], "canonical_name": "mitochondrion migration along actin filament", "definition": "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins. [GOC:mah, PMID:15979253, PMID:16306220]"}
{"concept_id": "C2612760", "aliases": ["microtubule-mediated mitochondrion localization", "establishment of mitochondrion localisation, microtubule-mediated", "mitochondrial localization, microtubule-mediated"], "types": ["T043"], "canonical_name": "establishment of mitochondrion localization, microtubule-mediated", "definition": "The directed movement of the mitochondrion to a specific location, by a process involving microtubules. [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220]"}
{"concept_id": "C2612761", "aliases": ["cellular response to ultraviolet radiation stimulus", "cellular response to UV light stimulus", "cellular response to UV radiation stimulus", "cellular response to ultraviolet light stimulus"], "types": ["T043"], "canonical_name": "cellular response to UV", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:mah]"}
{"concept_id": "C2612762", "aliases": ["cellular macromolecule biosynthesis", "cellular macromolecule formation", "cellular macromolecule synthesis", "cellular biopolymer biosynthetic process", "cellular macromolecule anabolism"], "types": ["T043"], "canonical_name": "cellular macromolecule biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. [GOC:mah]"}
{"concept_id": "C2612763", "aliases": [], "types": ["T026"], "canonical_name": "organelle-enclosing lipid monolayer", "definition": "A lipid monolayer that surrounds and encloses an organelle. [GOC:mah]"}
{"concept_id": "C2612764", "aliases": ["histone demethylase activity (H3-K4-me3 specific)", "histone demethylase activity (H3-trimethyl-K4 specific)"], "types": ["T044"], "canonical_name": "histone H3-tri/di/monomethyl-lysine-4 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:17550896, PMID:22473470]"}
{"concept_id": "C2612767", "aliases": ["cortisol metabolism"], "types": ["T044"], "canonical_name": "cortisol metabolic process", "definition": "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties. [GOC:BHF, GOC:mah, GOC:rl]"}
{"concept_id": "C2612768", "aliases": ["cortisol biosynthesis", "cortisol synthesis", "cortisol formation"], "types": ["T044"], "canonical_name": "cortisol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties. [GOC:BHF, GOC:mah, GOC:rl]"}
{"concept_id": "C2612769", "aliases": [], "types": ["T044"], "canonical_name": "cortisol anabolism"}
{"concept_id": "C2612771", "aliases": ["retinoic acid degradation", "vitamin A1 acid catabolic process", "retinoic acid breakdown", "retinoic acid catabolism"], "types": ["T044"], "canonical_name": "retinoic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612772", "aliases": ["nucleobase, nucleoside, nucleotide and nucleic acid formation", "nucleobase, nucleoside, nucleotide and nucleic acid anabolism", "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis"], "types": ["T045"], "canonical_name": "nucleobase-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:mah]"}
{"concept_id": "C2612773", "aliases": ["nucleobase, nucleoside, nucleotide and nucleic acid degradation", "nucleobase, nucleoside, nucleotide and nucleic acid catabolism", "nucleobase, nucleoside, nucleotide and nucleic acid breakdown"], "types": ["T044"], "canonical_name": "nucleobase-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:mah]"}
{"concept_id": "C2612774", "aliases": ["nucleobase, nucleoside and nucleotide breakdown", "nucleobase, nucleoside and nucleotide degradation", "nucleobase, nucleoside and nucleotide catabolism"], "types": ["T045"], "canonical_name": "nucleobase-containing small molecule catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. [GOC:mah]"}
{"concept_id": "C2612775", "aliases": ["GID complex location"], "types": ["T026"], "canonical_name": "GID complex", "definition": "A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p. [PMID:12686616, PMID:18508925]"}
{"concept_id": "C2612776", "aliases": [], "types": ["T044"], "canonical_name": "isopropylmalate transmembrane transporter activity", "definition": "Enables the transfer of isopropylmalate from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2612777", "aliases": [], "types": ["T043"], "canonical_name": "isopropylmalate transport", "definition": "The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2612778", "aliases": ["ncRNA metabolism"], "types": ["T045"], "canonical_name": "ncRNA metabolic process", "definition": "The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs). [GOC:mah]"}
{"concept_id": "C2612779", "aliases": ["ncRNA catabolism", "ncRNA breakdown", "ncRNA degradation"], "types": ["T045"], "canonical_name": "ncRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs). [GOC:rb, PMID:18591258]"}
{"concept_id": "C2612780", "aliases": ["CFTR-NHERF-ezrin complex location"], "types": ["T026"], "canonical_name": "CFTR-NHERF-ezrin complex", "definition": "A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity. [PMID:16129695, PMID:16798722, PMID:16926444]"}
{"concept_id": "C2612781", "aliases": ["ER chaperone complex location", "ER chaperone complex", "endoplasmic reticulum chaperone complex location"], "types": ["T026"], "canonical_name": "endoplasmic reticulum chaperone complex", "definition": "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. [PMID:12475965]"}
{"concept_id": "C2612782", "aliases": ["endoplasmic reticulum network complex location"], "types": ["T026"], "canonical_name": "endoplasmic reticulum network complex"}
{"concept_id": "C2612783", "aliases": ["ER network complex location"], "types": ["T026"], "canonical_name": "ER network complex"}
{"concept_id": "C2612784", "aliases": ["immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex", "immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex location", "Ig heavy chain-bound ER chaperone complex", "Ig heavy chain-bound endoplasmic reticulum chaperone complex location", "Ig heavy chain-bound ER chaperone complex location"], "types": ["T026"], "canonical_name": "Ig heavy chain-bound endoplasmic reticulum chaperone complex", "definition": "A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. [PMID:12475965]"}
{"concept_id": "C2612785", "aliases": ["VLA-1 complex location", "VLA-1 complex", "alpha1-beta1 integrin complex location", "alpha1-beta1 integrin complex", "integrin alpha1-beta1 complex location"], "types": ["T026"], "canonical_name": "integrin alpha1-beta1 complex", "definition": "An integrin complex that comprises one alpha1 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612786", "aliases": ["ITGA1-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA1-ITGB1 complex"}
{"concept_id": "C2612787", "aliases": ["VLA-2 complex", "integrin alpha2-beta1 complex location", "VLA-2 complex location"], "types": ["T026"], "canonical_name": "integrin alpha2-beta1 complex", "definition": "An integrin complex that comprises one alpha2 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612788", "aliases": ["ITGA2-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA2-ITGB1 complex"}
{"concept_id": "C2612789", "aliases": ["VLA-3 complex location", "alpha3-beta1 integrin complex", "alpha3-beta1 integrin complex location", "integrin alpha3-beta1 complex location", "VLA-3 complex"], "types": ["T026"], "canonical_name": "integrin alpha3-beta1 complex", "definition": "An integrin complex that comprises one alpha3 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612790", "aliases": ["ITGA3-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA3-ITGB1 complex"}
{"concept_id": "C2612791", "aliases": ["alpha4-beta1 integrin complex", "integrin alpha4-beta1 complex location", "VLA-4 complex", "alpha4-beta1 integrin complex location", "VLA-4 complex location"], "types": ["T026"], "canonical_name": "integrin alpha4-beta1 complex", "definition": "An integrin complex that comprises one alpha4 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612792", "aliases": ["ITGA4-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA4-ITGB1 complex"}
{"concept_id": "C2612793", "aliases": ["alpha4-beta7 integrin complex", "alpha4-beta7 integrin complex location", "integrin alpha4-beta7 complex location"], "types": ["T026"], "canonical_name": "integrin alpha4-beta7 complex", "definition": "An integrin complex that comprises one alpha4 subunit and one beta7 subunit. [PMID:12297042]"}
{"concept_id": "C2612794", "aliases": ["ITGA4-ITGB7 complex location"], "types": ["T026"], "canonical_name": "ITGA4-ITGB7 complex"}
{"concept_id": "C2612795", "aliases": [], "types": ["T043"], "canonical_name": "chemotaxis to arachidonic acid", "definition": "The directed movement of a motile cell or organism in response to the presence of arachidonic acid. [GOC:go_curators, PMID:18202452]"}
{"concept_id": "C2612796", "aliases": ["retinoic acid receptor signaling pathway involved in pronephric kidney anterior/posterior pattern specification", "retinoic acid receptor signalling pathway involved in pronephros anterior-posterior patterning"], "types": ["T044"], "canonical_name": "retinoic acid receptor signaling pathway involved in pronephros anterior/posterior pattern specification", "definition": "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros. [GOC:mh]"}
{"concept_id": "C2612798", "aliases": ["inhibin-betaglycan-ActRII complex location"], "types": ["T026"], "canonical_name": "inhibin-betaglycan-ActRII complex", "definition": "A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B. [GOC:BHF, PMID:10746731]"}
{"concept_id": "C2612799", "aliases": ["alpha5-beta1 integrin complex", "VLA-5 complex", "VLA-5 complex location", "alpha5-beta1 integrin complex location", "integrin alpha5-beta1 complex location"], "types": ["T026"], "canonical_name": "integrin alpha5-beta1 complex", "definition": "An integrin complex that comprises one alpha5 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612800", "aliases": ["ITGA5-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA5-ITGB1 complex"}
{"concept_id": "C2612801", "aliases": ["integrin alpha6-beta1 complex location", "alpha6-beta1 integrin complex", "alpha6-beta1 integrin complex location", "VLA-6 complex", "VLA-6 complex location"], "types": ["T026"], "canonical_name": "integrin alpha6-beta1 complex", "definition": "An integrin complex that comprises one alpha6 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612802", "aliases": ["ITGA6-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA6-ITGB1 complex"}
{"concept_id": "C2612803", "aliases": ["alpha6-beta4 integrin complex", "integrin alpha6-beta4 complex location", "alpha6-beta4 integrin complex location"], "types": ["T026"], "canonical_name": "integrin alpha6-beta4 complex", "definition": "An integrin complex that comprises one alpha6 subunit and one beta4 subunit. [PMID:12297042]"}
{"concept_id": "C2612804", "aliases": ["ITGA6-ITGB4 complex location"], "types": ["T026"], "canonical_name": "ITGA6-ITGB4 complex"}
{"concept_id": "C2612805", "aliases": ["alpha7-beta1 integrin complex", "integrin alpha7-beta1 complex location", "alpha7-beta1 integrin complex location"], "types": ["T026"], "canonical_name": "integrin alpha7-beta1 complex", "definition": "An integrin complex that comprises one alpha7 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612806", "aliases": ["ITGA7-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA7-ITGB1 complex"}
{"concept_id": "C2612807", "aliases": ["integrin alpha8-beta1 complex location", "alpha8-beta1 integrin complex location", "alpha8-beta1 integrin complex"], "types": ["T026"], "canonical_name": "integrin alpha8-beta1 complex", "definition": "An integrin complex that comprises one alpha8 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612808", "aliases": ["ITGA8-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA8-ITGB1 complex"}
{"concept_id": "C2612809", "aliases": ["alpha9-beta1 integrin complex location", "alpha9-beta1 integrin complex", "integrin alpha9-beta1 complex location"], "types": ["T026"], "canonical_name": "integrin alpha9-beta1 complex", "definition": "An integrin complex that comprises one alpha9 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612810", "aliases": ["ITGA9-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA9-ITGB1 complex"}
{"concept_id": "C2612811", "aliases": ["integrin alpha10-beta1 complex location", "alpha10-beta1 integrin complex", "alpha10-beta1 integrin complex location"], "types": ["T026"], "canonical_name": "integrin alpha10-beta1 complex", "definition": "An integrin complex that comprises one alpha10 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612812", "aliases": ["ITGA10-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA10-ITGB1 complex"}
{"concept_id": "C2612813", "aliases": ["alpha11-beta1 integrin complex", "alpha11-beta1 integrin complex location", "integrin alpha11-beta1 complex location"], "types": ["T026"], "canonical_name": "integrin alpha11-beta1 complex", "definition": "An integrin complex that comprises one alpha11 subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612814", "aliases": ["ITGA11-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGA11-ITGB1 complex"}
{"concept_id": "C2612815", "aliases": ["alphav-beta1 integrin complex", "alphav-beta1 integrin complex location", "integrin alphav-beta1 complex location"], "types": ["T026"], "canonical_name": "integrin alphav-beta1 complex", "definition": "An integrin complex that comprises one alphav subunit and one beta1 subunit. [PMID:12297042]"}
{"concept_id": "C2612816", "aliases": ["ITGAV-ITGB1 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB1 complex"}
{"concept_id": "C2612817", "aliases": ["alphav-beta3 integrin complex", "integrin alphav-beta3 complex location", "alphav-beta3 integrin complex location"], "types": ["T026"], "canonical_name": "integrin alphav-beta3 complex", "definition": "An integrin complex that comprises one alphav subunit and one beta3 subunit. [PMID:12297042]"}
{"concept_id": "C2612818", "aliases": ["ITGAV-ITGB3 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3 complex"}
{"concept_id": "C2612819", "aliases": ["integrin alphav-beta5 complex location", "alphav-beta5 integrin complex location", "alphav-beta5 integrin complex"], "types": ["T026"], "canonical_name": "integrin alphav-beta5 complex", "definition": "An integrin complex that comprises one alphav subunit and one beta5 subunit. [PMID:12297042]"}
{"concept_id": "C2612820", "aliases": ["ITGAV-ITGB5 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB5 complex"}
{"concept_id": "C2612821", "aliases": ["integrin alphav-beta6 complex location", "alphav-beta6 integrin complex", "alphav-beta6 integrin complex location"], "types": ["T026"], "canonical_name": "integrin alphav-beta6 complex", "definition": "An integrin complex that comprises one alphav subunit and one beta6 subunit. [PMID:12297042]"}
{"concept_id": "C2612822", "aliases": ["ITGAV-ITGB6 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB6 complex"}
{"concept_id": "C2612823", "aliases": ["alphav-beta8 integrin complex", "integrin alphav-beta8 complex location", "alphav-beta8 integrin complex location"], "types": ["T026"], "canonical_name": "integrin alphav-beta8 complex", "definition": "An integrin complex that comprises one alphav subunit and one beta8 subunit. [PMID:12297042]"}
{"concept_id": "C2612824", "aliases": ["ITGAV-ITGB8 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB8 complex"}
{"concept_id": "C2612825", "aliases": ["alphaL-beta2 integrin complex location", "alphaL-beta2 integrin complex", "integrin alphaL-beta2 complex location"], "types": ["T026"], "canonical_name": "integrin alphaL-beta2 complex", "definition": "An integrin complex that comprises one alphaL subunit and one beta2 subunit. [PMID:12297042]"}
{"concept_id": "C2612826", "aliases": ["Itgal-Itgb2 complex location"], "types": ["T026"], "canonical_name": "Itgal-Itgb2 complex"}
{"concept_id": "C2612827", "aliases": ["integrin alphaM-beta2 complex location", "alphaM-beta2 integrin complex location", "alphaM-beta2 integrin complex"], "types": ["T026"], "canonical_name": "integrin alphaM-beta2 complex", "definition": "An integrin complex that comprises one alphaM subunit and one beta2 subunit. [PMID:12297042]"}
{"concept_id": "C2612828", "aliases": ["Itgam-Itgb2 complex location"], "types": ["T026"], "canonical_name": "Itgam-Itgb2 complex"}
{"concept_id": "C2612829", "aliases": ["integrin alphaX-beta2 complex location", "alphaX-beta2 integrin complex location", "alphaX-beta2 integrin complex"], "types": ["T026"], "canonical_name": "integrin alphaX-beta2 complex", "definition": "An integrin complex that comprises one alphaX subunit and one beta2 subunit. [PMID:12297042]"}
{"concept_id": "C2612830", "aliases": ["Itgax-Itgb2 complex location"], "types": ["T026"], "canonical_name": "Itgax-Itgb2 complex"}
{"concept_id": "C2612831", "aliases": ["integrin alphaD-beta2 complex location", "alphaD-beta2 integrin complex", "alphaD-beta2 integrin complex location"], "types": ["T026"], "canonical_name": "integrin alphaD-beta2 complex", "definition": "An integrin complex that comprises one alphaD subunit and one beta2 subunit. [PMID:12297042]"}
{"concept_id": "C2612832", "aliases": ["Itgad-Itgb2 complex location"], "types": ["T026"], "canonical_name": "Itgad-Itgb2 complex"}
{"concept_id": "C2612833", "aliases": ["integrin alphaE-beta7 complex location"], "types": ["T026"], "canonical_name": "integrin alphaE-beta7 complex", "definition": "An integrin complex that comprises one alphaE subunit and one beta7 subunit. [PMID:12297042]"}
{"concept_id": "C2612834", "aliases": ["Itgae-Itgb7 complex location"], "types": ["T026"], "canonical_name": "Itgae-Itgb7 complex"}
{"concept_id": "C2612835", "aliases": ["E.F.G complex location"], "types": ["T026"], "canonical_name": "E.F.G complex", "definition": "A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex. [PMID:8641291]"}
{"concept_id": "C2612836", "aliases": ["snRNP U11/U12", "U11/U12 snRNP location", "U11/U12 snRNP"], "types": ["T026"], "definition": "A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins. [GOC:mah, PMID:15146077]", "canonical_name": "snRNP U11/U12 location"}
{"concept_id": "C2612837", "aliases": ["18S U11/U12 snRNP location"], "types": ["T026"], "canonical_name": "18S U11/U12 snRNP"}
{"concept_id": "C2612838", "aliases": ["response to prostaglandin stimulus"], "types": ["T043"], "canonical_name": "response to prostaglandin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2612839", "aliases": ["response to prostaglandin E stimulus"], "types": ["T043"], "canonical_name": "response to prostaglandin E", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2612840", "aliases": ["response to prostaglandin F stimulus"], "types": ["T043"], "canonical_name": "response to prostaglandin F", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2612841", "aliases": ["response to prostaglandin I stimulus"], "types": ["T043"], "canonical_name": "response to prostaglandin I", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2612842", "aliases": ["response to gonadotropin stimulus"], "types": ["T043"], "canonical_name": "response to gonadotropin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2612843", "aliases": ["response to luteinizing hormone stimulus"], "types": ["T043"], "canonical_name": "response to luteinizing hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2612844", "aliases": [], "types": ["T044"], "canonical_name": "allulose 6-phosphate 3-epimerase activity", "definition": "Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate. [GOC:imk]"}
{"concept_id": "C2612845", "aliases": [], "types": ["T044"], "canonical_name": "tripeptidase activity", "definition": "Catalysis of the hydrolysis of a tripeptide. [GOC:mah]"}
{"concept_id": "C2612846", "aliases": ["ion channel complex location"], "types": ["T026"], "canonical_name": "ion channel complex", "definition": "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. [GOC:mah, ISBN:071673706X]"}
{"concept_id": "C2612847", "aliases": ["cation channel complex location"], "types": ["T026"], "canonical_name": "cation channel complex", "definition": "An ion channel complex through which cations pass. [GOC:mah]"}
{"concept_id": "C2612848", "aliases": ["calcium channel complex location"], "types": ["T026"], "canonical_name": "calcium channel complex", "definition": "An ion channel complex through which calcium ions pass. [GOC:mah]"}
{"concept_id": "C2612849", "aliases": ["potassium channel complex location"], "types": ["T026"], "canonical_name": "potassium channel complex", "definition": "An ion channel complex through which potassium ions pass. [GOC:mah]"}
{"concept_id": "C2612850", "aliases": ["sodium channel complex location"], "types": ["T026"], "canonical_name": "sodium channel complex", "definition": "An ion channel complex through which sodium ions pass. [GOC:mah]"}
{"concept_id": "C2612851", "aliases": ["chloride channel complex location"], "types": ["T026"], "canonical_name": "chloride channel complex", "definition": "An ion channel complex through which chloride ions pass. [GOC:mah]"}
{"concept_id": "C2612852", "aliases": ["methyltransferase complex location"], "types": ["T026"], "canonical_name": "methyltransferase complex", "definition": "A protein complex that possesses methyltransferase activity. [GOC:mah]"}
{"concept_id": "C2612853", "aliases": ["20S methyltransferase complex location", "20S methylosome", "20S methyltransferase complex"], "types": ["T026"], "canonical_name": "methylosome", "definition": "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. [PMID:11713266, PMID:11756452]"}
{"concept_id": "C2612854", "aliases": [], "types": ["T044"], "canonical_name": "inhibin complex binding", "definition": "Binding to an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612855", "aliases": ["inhibin monomer binding"], "types": ["T044"], "canonical_name": "inhibin binding", "definition": "Binding to an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612856", "aliases": [], "types": ["T044"], "canonical_name": "inhibin alpha binding"}
{"concept_id": "C2612857", "aliases": ["transforming growth factor beta receptor type I binding", "TGF-beta type I binding", "type I TGF-beta binding"], "types": ["T044"], "canonical_name": "type I transforming growth factor beta receptor binding", "definition": "Binding to a type I transforming growth factor beta receptor. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612858", "aliases": ["baboon ligand"], "types": ["T044"], "canonical_name": "babo ligand"}
{"concept_id": "C2612859", "aliases": [], "types": ["T044"], "canonical_name": "baboon receptor ligand"}
{"concept_id": "C2612860", "aliases": ["saxophone ligand"], "types": ["T044"], "canonical_name": "sax ligand"}
{"concept_id": "C2612861", "aliases": [], "types": ["T044"], "canonical_name": "thickveins ligand"}
{"concept_id": "C2612862", "aliases": [], "types": ["T044"], "canonical_name": "tkv binding"}
{"concept_id": "C2612863", "aliases": [], "types": ["T044"], "canonical_name": "tkv ligand"}
{"concept_id": "C2612864", "aliases": ["type IIII TGF-beta binding", "transforming growth factor beta receptor type III binding", "TGF-beta type III binding"], "types": ["T044"], "canonical_name": "type III transforming growth factor beta receptor binding", "definition": "Binding to a type III transforming growth factor beta receptor. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2612865", "aliases": [], "types": ["T044"], "canonical_name": "betaglycan binding"}
{"concept_id": "C2612866", "aliases": ["pICln-Sm protein complex location", "6S pICln complex", "6S pICln complex location"], "types": ["T026"], "canonical_name": "pICln-Sm protein complex", "definition": "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG. [GOC:mah, PMID:11713266]"}
{"concept_id": "C2612867", "aliases": ["Gemin3-Gemin4-Gemin5 complex location"], "types": ["T026"], "canonical_name": "Gemin3-Gemin4-Gemin5 complex", "definition": "A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly. [GOC:mah, PMID:17640873]"}
{"concept_id": "C2612868", "aliases": ["Gemin6-Gemin7-unrip complex location"], "types": ["T026"], "canonical_name": "Gemin6-Gemin7-unrip complex", "definition": "A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly. [GOC:mah, PMID:17640873]"}
{"concept_id": "C2612869", "aliases": ["SMN-Gemin2 complex location"], "types": ["T026"], "canonical_name": "SMN-Gemin2 complex", "definition": "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex. [GOC:mah, PMID:17640873]"}
{"concept_id": "C2612870", "aliases": ["SMN-Sm protein complex location"], "types": ["T026"], "canonical_name": "SMN-Sm protein complex", "definition": "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. [GOC:vw, PMID:11522829, PMID:17401408]"}
{"concept_id": "C2612871", "aliases": ["SMN-containing protein complex", "SMN-containing protein complex location"], "types": ["T026"], "canonical_name": "SMN-containing protein complex"}
{"concept_id": "C2612872", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K4 demethylation", "definition": "The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone. [GOC:mah]"}
{"concept_id": "C2612873", "aliases": [], "types": ["T044"], "canonical_name": "H3K4 demethylation (me1 me2 and me3)"}
{"concept_id": "C2612874", "aliases": ["H3K4 demethylation (me3)"], "types": ["T044"], "canonical_name": "histone H3-K4 demethylation, trimethyl-H3-K4-specific", "definition": "The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone. [GOC:mah]"}
{"concept_id": "C2612875", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K4 tridemethylation"}
{"concept_id": "C2612876", "aliases": ["gamma-glutamyl hydrolase activity"], "types": ["T044"], "definition": "Catalysis of the cleavage of a gamma-linked glutamate bond. [EC:3.4.19.9, MEROPS_fam:C26]", "canonical_name": "gamma-glutamyl-peptidase activity"}
{"concept_id": "C2612877", "aliases": ["DNA replication-dependent nucleosome organization", "DNA replication-dependent nucleosome organisation"], "types": ["T045"], "canonical_name": "DNA replication-dependent chromatin organization", "definition": "The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. [GOC:mah, PMID:17510629]"}
{"concept_id": "C2612878", "aliases": ["DNA replication-independent nucleosome organisation"], "types": ["T045"], "canonical_name": "DNA replication-independent chromatin organization", "definition": "The formation or destruction of chromatin structures, occurring outside the context of DNA replication. [GOC:mah, PMID:17510629]"}
{"concept_id": "C2612881", "aliases": ["piecemeal microautophagy of the nucleus"], "types": ["T043"], "definition": "Degradation of a cell nucleus by lysosomal microautophagy. [GOC:autophagy, GOC:jp, PMID:18701704]", "canonical_name": "PMN"}
{"concept_id": "C2612882", "aliases": ["nucleosome organisation"], "types": ["T043"], "canonical_name": "nucleosome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. [GOC:mah]"}
{"concept_id": "C2612883", "aliases": ["histone lysine H3 K79 methylation", "histone H3 K79 methylation", "histone H3K79me"], "types": ["T044"], "canonical_name": "histone H3-K79 methylation", "definition": "The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone. [GOC:se]"}
{"concept_id": "C2612884", "aliases": ["SmD-containing SMN-Sm protein complex location"], "types": ["T026"], "canonical_name": "SmD-containing SMN-Sm protein complex", "definition": "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex. [PMID:12975319, PMID:17401408]"}
{"concept_id": "C2612885", "aliases": ["Lsm-containing SMN-Sm protein complex location"], "types": ["T026"], "canonical_name": "Lsm-containing SMN-Sm protein complex", "definition": "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA. [PMID:12975319, PMID:17401408]"}
{"concept_id": "C2612886", "aliases": ["transcription factor TFIIIB-alpha complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIIB-alpha complex", "definition": "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters. [PMID:11433012]"}
{"concept_id": "C2612887", "aliases": ["transcription factor TFIIIB-beta complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIIB-beta complex", "definition": "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters. [PMID:11433012]"}
{"concept_id": "C2612888", "aliases": ["transcription factor TFIIIC1 complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIIC1 complex", "definition": "A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity. [GOC:mah, PMID:11433012, PMID:15096501]"}
{"concept_id": "C2612889", "aliases": ["transcription factor TFIIIC2 complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIIC2 complex", "definition": "A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter. [GOC:mah, PMID:11433012]"}
{"concept_id": "C2612890", "aliases": ["cholesteryl ester synthetase activity", "acyl coenzyme A-cholesterol-O-acyltransferase activity", "acylcoenzyme A:cholesterol O-acyltransferase activity", "cholesterol ester synthetase activity", "acyl-CoA:cholesterol O-acyltransferase activity", "acyl-CoA:cholesterol acyltransferase activity"], "types": ["T044"], "canonical_name": "cholesterol O-acyltransferase activity", "definition": "Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA. [EC:2.3.1.26, RHEA:17729]"}
{"concept_id": "C2612891", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol acyltransferase activity"}
{"concept_id": "C2612892", "aliases": [], "types": ["T044"], "canonical_name": "ergosterol O-acyltransferase activity", "definition": "Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester. [GOC:mah]"}
{"concept_id": "C2612893", "aliases": [], "types": ["T044"], "canonical_name": "lanosterol O-acyltransferase activity", "definition": "Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester. [GOC:mah]"}
{"concept_id": "C2612895", "aliases": ["TFIIIC-TOP1-SUB1 complex location", "TFIIIC-Topoisomerase 1-PC4 complex", "TFIIIC-Topoisomerase 1-PC4 complex location"], "types": ["T026"], "canonical_name": "TFIIIC-TOP1-SUB1 complex", "definition": "A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III. [PMID:9660958]"}
{"concept_id": "C2612896", "aliases": ["APC-tubulin-IQGAP1 complex location"], "types": ["T026"], "canonical_name": "APC-tubulin-IQGAP1 complex", "definition": "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization. [PMID:17126424]"}
{"concept_id": "C2612897", "aliases": ["60S APC complex location"], "types": ["T026"], "canonical_name": "60S APC complex"}
{"concept_id": "C2612899", "aliases": ["23S APC complex location"], "types": ["T026"], "canonical_name": "23S APC complex"}
{"concept_id": "C2612900", "aliases": ["APC-IQGAP complex location"], "types": ["T026"], "canonical_name": "APC-IQGAP complex", "definition": "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. [PMID:15572129]"}
{"concept_id": "C2612901", "aliases": ["APC-IQGAP1-Cdc42 complex location"], "types": ["T026"], "canonical_name": "APC-IQGAP1-Cdc42 complex", "definition": "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. [PMID:15572129]"}
{"concept_id": "C2612902", "aliases": ["APC-IQGAP1-Rac1 complex location"], "types": ["T026"], "canonical_name": "APC-IQGAP1-Rac1 complex", "definition": "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. [PMID:15572129]"}
{"concept_id": "C2612903", "aliases": ["APC-IQGAP1-CLIP-170 complex location"], "types": ["T026"], "canonical_name": "APC-IQGAP1-CLIP-170 complex", "definition": "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration. [PMID:15572129]"}
{"concept_id": "C2612905", "aliases": ["Par3-APC-KIF3A complex location"], "types": ["T026"], "canonical_name": "Par3-APC-KIF3A complex", "definition": "A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity. [PMID:15556865]"}
{"concept_id": "C2612906", "aliases": ["Scrib-APC complex location"], "types": ["T026"], "canonical_name": "Scrib-APC complex", "definition": "A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation. [PMID:16611247]"}
{"concept_id": "C2612907", "aliases": ["hScrib-APC complex location"], "types": ["T026"], "canonical_name": "hScrib-APC complex"}
{"concept_id": "C2612908", "aliases": ["Scrib-APC-beta-catenin complex location"], "types": ["T026"], "canonical_name": "Scrib-APC-beta-catenin complex", "definition": "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation. [PMID:16611247]"}
{"concept_id": "C2612909", "aliases": ["hScrib-APC-beta-catenin complex location"], "types": ["T026"], "canonical_name": "hScrib-APC-beta-catenin complex"}
{"concept_id": "C2612910", "aliases": ["AHRC", "AhR complex", "aryl hydrocarbon receptor complex location", "AhR complex location"], "types": ["T026"], "canonical_name": "aryl hydrocarbon receptor complex", "definition": "A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR. [GOC:mah, PMID:7598497]"}
{"concept_id": "C2612911", "aliases": ["cytosolic aryl hydrocarbon receptor complex location", "cytosolic AhR complex location", "cytosolic AHRC", "cytosolic AhR complex"], "types": ["T026"], "canonical_name": "cytosolic aryl hydrocarbon receptor complex", "definition": "An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP. [PMID:7598497, PMID:8937476, PMID:9447995]"}
{"concept_id": "C2612912", "aliases": ["9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex location"], "types": ["T026"], "canonical_name": "9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex"}
{"concept_id": "C2612913", "aliases": ["nuclear AhR complex location", "nuclear AHRC", "nuclear aryl hydrocarbon receptor complex location", "nuclear AhR complex"], "types": ["T026"], "canonical_name": "nuclear aryl hydrocarbon receptor complex", "definition": "An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT). [PMID:7598497]"}
{"concept_id": "C2612914", "aliases": ["6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex location"], "types": ["T026"], "canonical_name": "6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex"}
{"concept_id": "C2612915", "aliases": [], "types": ["T044"], "canonical_name": "cellular hormone metabolic process", "definition": "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. [GOC:mah]"}
{"concept_id": "C2612916", "aliases": ["iron ion membrane transport", "transmembrane iron transport"], "types": ["T044"], "canonical_name": "iron ion transmembrane transport", "definition": "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah, PMID:11390404]"}
{"concept_id": "C2612917", "aliases": ["regulation of iron transport", "regulation of Fe transport"], "types": ["T043"], "canonical_name": "regulation of iron ion transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2612918", "aliases": ["down regulation of iron ion transport", "down-regulation of iron ion transport", "negative regulation of iron transport", "downregulation of iron ion transport"], "types": ["T043"], "canonical_name": "negative regulation of iron ion transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2612919", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of iron ion transport"}
{"concept_id": "C2612920", "aliases": ["up regulation of iron ion transport", "upregulation of iron ion transport", "positive regulation of iron transport", "up-regulation of iron ion transport"], "types": ["T043"], "canonical_name": "positive regulation of iron ion transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2612921", "aliases": ["stimulation of iron ion transport"], "types": ["T043"], "canonical_name": "activation of iron ion transport"}
{"concept_id": "C2612922", "aliases": ["regulation of iron ion membrane transport", "regulation of transmembrane Fe transport", "regulation of transmembrane iron transport", "regulation of transmembrane iron ion transport"], "types": ["T043"], "canonical_name": "regulation of iron ion transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2612923", "aliases": ["down regulation of transmembrane iron ion transport", "negative regulation of transmembrane iron transport", "negative regulation of transmembrane iron ion transport", "downregulation of transmembrane iron ion transport", "down-regulation of transmembrane iron ion transport", "negative regulation of iron ion membrane transport"], "types": ["T043"], "canonical_name": "negative regulation of iron ion transmembrane transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2612924", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of transmembrane iron ion transport"}
{"concept_id": "C2612925", "aliases": ["positive regulation of iron ion membrane transport", "up-regulation of transmembrane iron ion transport", "positive regulation of transmembrane iron ion transport", "positive regulation of transmembrane iron transport", "upregulation of transmembrane iron ion transport", "up regulation of transmembrane iron ion transport"], "types": ["T043"], "canonical_name": "positive regulation of iron ion transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2612926", "aliases": ["stimulation of transmembrane iron ion transport"], "types": ["T043"], "canonical_name": "activation of transmembrane iron ion transport"}
{"concept_id": "C2612927", "aliases": ["regulation of membrane transport"], "types": ["T043"], "canonical_name": "regulation of transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2612928", "aliases": ["down regulation of transmembrane transport", "down-regulation of transmembrane transport", "downregulation of transmembrane transport", "negative regulation of membrane transport"], "types": ["T043"], "canonical_name": "negative regulation of transmembrane transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2612929", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of transmembrane transport"}
{"concept_id": "C2612930", "aliases": ["upregulation of transmembrane transport", "positive regulation of membrane transport", "up regulation of transmembrane transport", "up-regulation of transmembrane transport"], "types": ["T043"], "canonical_name": "positive regulation of transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2612931", "aliases": ["stimulation of transmembrane transport"], "types": ["T043"], "canonical_name": "activation of transmembrane transport"}
{"concept_id": "C2612932", "aliases": ["regulation of ion membrane transport", "regulation of transmembrane ion transport"], "types": ["T043"], "canonical_name": "regulation of ion transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2612933", "aliases": ["negative regulation of ion membrane transport", "negative regulation of transmembrane ion transport", "downregulation of transmembrane ion transport", "down regulation of transmembrane ion transport", "down-regulation of transmembrane ion transport"], "types": ["T043"], "canonical_name": "negative regulation of ion transmembrane transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2612934", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of transmembrane ion transport"}
{"concept_id": "C2612935", "aliases": ["upregulation of transmembrane ion transport", "positive regulation of ion membrane transport", "up regulation of transmembrane ion transport", "positive regulation of transmembrane ion transport", "up-regulation of transmembrane ion transport"], "types": ["T043"], "canonical_name": "positive regulation of ion transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2612936", "aliases": ["stimulation of transmembrane ion transport"], "types": ["T043"], "canonical_name": "activation of transmembrane ion transport"}
{"concept_id": "C2612937", "aliases": [], "types": ["T044"], "canonical_name": "(E)-beta-ocimene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate. [EC:4.2.3.106, PMID:12624761]"}
{"concept_id": "C2612938", "aliases": [], "types": ["T043"], "canonical_name": "basement membrane disassembly", "definition": "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. [GOC:sart, PMID:17301221]"}
{"concept_id": "C2612939", "aliases": ["histone lysine H4 K20 methylation", "histone H4K20me", "histone H4 K20 methylation"], "types": ["T044"], "canonical_name": "histone H4-K20 methylation", "definition": "The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone. [GOC:mah]"}
{"concept_id": "C2612940", "aliases": ["histone lysine H4 K20 monomethylation", "histone H4 K20 monomethylation"], "types": ["T044"], "canonical_name": "histone H4-K20 monomethylation", "definition": "The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone. [GOC:mah]"}
{"concept_id": "C2612941", "aliases": ["histone lysine H4 K20 dimethylation", "histone H4 K20 dimethylation"], "types": ["T044"], "canonical_name": "histone H4-K20 dimethylation", "definition": "The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone. [GOC:mah]"}
{"concept_id": "C2612942", "aliases": ["histone H4 K20 trimethylation", "histone lysine H4 K20 trimethylation"], "types": ["T044"], "canonical_name": "histone H4-K20 trimethylation", "definition": "The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone. [GOC:mah]"}
{"concept_id": "C2612943", "aliases": [], "types": ["T026"], "canonical_name": "secretory granule lumen", "definition": "The volume enclosed by the membrane of a secretory granule. [GOC:rph]"}
{"concept_id": "C2612944", "aliases": ["transmembrane glutathione transport", "glutathione membrane transport"], "types": ["T043"], "canonical_name": "glutathione transmembrane transport", "definition": "A process in which glutathione is transported across a membrane. [GOC:mah]"}
{"concept_id": "C2612945", "aliases": ["response to histamine stimulus"], "types": ["T043"], "canonical_name": "response to histamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. [GOC:BHF, GOC:mah, GOC:vk]"}
{"concept_id": "C2612946", "aliases": [], "types": ["T026"], "canonical_name": "recycling endosome lumen", "definition": "The volume enclosed by the membranes of a recycling endosome. [GOC:rph]"}
{"concept_id": "C2612947", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-. [UM-BBD_reactionID:r1003]"}
{"concept_id": "C2612948", "aliases": [], "types": ["T044"], "canonical_name": "4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA. [UM-BBD_reactionID:r1004]"}
{"concept_id": "C2612949", "aliases": [], "types": ["T044"], "canonical_name": "glyphosate dehydrogenase activity", "definition": "Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-. [UM-BBD_reactionID:r0073]"}
{"concept_id": "C2612950", "aliases": [], "types": ["T044"], "canonical_name": "N-cyclohexylformamide amidohydrolase activity", "definition": "Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate. [UM-BBD_reactionID:r1030]"}
{"concept_id": "C2612951", "aliases": [], "types": ["T044"], "canonical_name": "dimethylmalonate decarboxylase activity", "definition": "Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2. [UM-BBD_reactionID:r1031]"}
{"concept_id": "C2612952", "aliases": [], "types": ["T044"], "canonical_name": "pivalate-CoA ligase activity", "definition": "Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP. [UM-BBD_reactionID:r1032]"}
{"concept_id": "C2612953", "aliases": [], "types": ["T044"], "canonical_name": "pivalyl-CoA mutase activity", "definition": "Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA. [UM-BBD_reactionID:r1033]"}
{"concept_id": "C2612954", "aliases": [], "types": ["T044"], "canonical_name": "salicylate 5-hydroxylase activity", "definition": "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+. [UM-BBD_reactionID:r1034]"}
{"concept_id": "C2612955", "aliases": [], "types": ["T044"], "canonical_name": "9-fluorenone-3,4-dioxygenase activity", "definition": "Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone. [UM-BBD_reactionID:r1039]"}
{"concept_id": "C2612956", "aliases": [], "types": ["T044"], "canonical_name": "1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity", "definition": "Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-. [UM-BBD_reactionID:r1040]"}
{"concept_id": "C2612957", "aliases": [], "types": ["T044"], "canonical_name": "2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+. [UM-BBD_reactionID:r1041]"}
{"concept_id": "C2612958", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+. [UM-BBD_reactionID:r1042]"}
{"concept_id": "C2612959", "aliases": [], "types": ["T044"], "canonical_name": "3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity", "definition": "Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-. [UM-BBD_reactionID:r1043]"}
{"concept_id": "C2612960", "aliases": [], "types": ["T044"], "canonical_name": "isobutylamine N-hydroxylase activity", "definition": "Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O. [UM-BBD_reactionID:r1053]"}
{"concept_id": "C2612961", "aliases": [], "types": ["T044"], "canonical_name": "hypophosphite dioxygenase activity", "definition": "Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2. [UM-BBD_reactionID:r1058]"}
{"concept_id": "C2612962", "aliases": [], "types": ["T044"], "canonical_name": "cyclopropanecarboxylate-CoA ligase activity", "definition": "Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-. [UM-BBD_reactionID:r1056]"}
{"concept_id": "C2612963", "aliases": [], "types": ["T044"], "canonical_name": "cyclopropanecarboxyl-CoA decyclase activity", "definition": "Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA. [UM-BBD_reactionID:r1057]"}
{"concept_id": "C2612964", "aliases": ["butane monooxygenase activity"], "types": ["T044"], "canonical_name": "butane monooxygenase activity", "definition": "Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O. [GOC:dh, PMID:17526838, PMID:19383682]"}
{"concept_id": "C2612965", "aliases": [], "types": ["T044"], "canonical_name": "adipate-CoA ligase activity", "definition": "Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-. [UM-BBD_reactionID:r1060]"}
{"concept_id": "C2612966", "aliases": [], "types": ["T044"], "canonical_name": "fosfomycin 2-glutathione ligase activity", "definition": "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid. [UM-BBD_reactionID:r1073]"}
{"concept_id": "C2612967", "aliases": [], "types": ["T044"], "canonical_name": "fosfomycin 2-L-cysteine ligase activity", "definition": "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid. [UM-BBD_reactionID:r1074]"}
{"concept_id": "C2612968", "aliases": [], "types": ["T044"], "canonical_name": "dihydride TNP tautomerase activity", "definition": "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form). [UM-BBD_reactionID:r1070]"}
{"concept_id": "C2612969", "aliases": ["TNP dihydride denitratase activity", "2,4,6-trinitrophenol dihydride denitratase activity"], "types": ["T044"], "canonical_name": "trinitrophenol dihydride denitratase activity", "definition": "Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP. [UM-BBD_reactionID:r1067]"}
{"concept_id": "C2612970", "aliases": [], "types": ["T044"], "canonical_name": "2,4-dinitrocyclohexanone hydrolase activity", "definition": "Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate. [UM-BBD_reactionID:r1069]"}
{"concept_id": "C2612971", "aliases": [], "types": ["T044"], "canonical_name": "branched-chain dodecylbenzene sulfonate monooxygenase activity", "definition": "Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite. [UM-BBD_reactionID:r1079]"}
{"concept_id": "C2612972", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-2-naphthoate 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate. [UM-BBD_reactionID:r1104]"}
{"concept_id": "C2612973", "aliases": [], "types": ["T044"], "canonical_name": "benzo(a)pyrene 11,12-epoxidase activity", "definition": "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide. [UM-BBD_reactionID:r1119]"}
{"concept_id": "C2612974", "aliases": [], "types": ["T044"], "canonical_name": "benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity", "definition": "Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-. [UM-BBD_reactionID:r1121]"}
{"concept_id": "C2612975", "aliases": [], "types": ["T044"], "canonical_name": "benzo(a)pyrene 11,12-dioxygenase activity", "definition": "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol. [UM-BBD_reactionID:r1124]"}
{"concept_id": "C2612976", "aliases": [], "types": ["T044"], "canonical_name": "4,5-dihydroxybenzo(a)pyrene methyltransferase activity", "definition": "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene. [UM-BBD_reactionID:r1131]"}
{"concept_id": "C2612977", "aliases": [], "types": ["T044"], "canonical_name": "benzo(a)pyrene 4,5-dioxygenase activity", "definition": "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol. [UM-BBD_reactionID:r1126]"}
{"concept_id": "C2612978", "aliases": [], "types": ["T044"], "canonical_name": "benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity", "definition": "Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2. [UM-BBD_reactionID:r1127]"}
{"concept_id": "C2612979", "aliases": [], "types": ["T044"], "canonical_name": "4,5-dihydroxybenzo(a)pyrene dioxygenase activity", "definition": "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate. [UM-BBD_reactionID:r1128]"}
{"concept_id": "C2612980", "aliases": [], "types": ["T044"], "canonical_name": "benzo(a)pyrene 9,10-dioxygenase activity", "definition": "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol. [UM-BBD_reactionID:r1132]"}
{"concept_id": "C2612981", "aliases": [], "types": ["T044"], "canonical_name": "9,10-dihydroxybenzo(a)pyrene dioxygenase activity", "definition": "Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate. [UM-BBD_reactionID:r1134]"}
{"concept_id": "C2612982", "aliases": [], "types": ["T044"], "canonical_name": "benzo(a)pyrene 7,8-dioxygenase activity", "definition": "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol. [UM-BBD_reactionID:1137]"}
{"concept_id": "C2612983", "aliases": [], "types": ["T044"], "canonical_name": "7,8-dihydroxy benzo(a)pyrene dioxygenase activity", "definition": "Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate. [UM-BBD_reactionID:r1138]"}
{"concept_id": "C2612984", "aliases": [], "types": ["T044"], "canonical_name": "cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity", "definition": "Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+. [UM-BBD_reactionID:r1135]"}
{"concept_id": "C2612985", "aliases": [], "types": ["T044"], "canonical_name": "anthracene 9,10-dioxygenase activity", "definition": "Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol. [UM-BBD_reactionID:r1141]"}
{"concept_id": "C2612986", "aliases": [], "types": ["T044"], "canonical_name": "cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity", "definition": "Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-. [UM-BBD_reactionID:r1144]"}
{"concept_id": "C2612987", "aliases": [], "types": ["T044"], "canonical_name": "ADD 9alpha-hydroxylase activity", "definition": "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin. [UM-BBD_reactionID:r1149]"}
{"concept_id": "C2612988", "aliases": [], "types": ["T044"], "canonical_name": "3-HSA hydroxylase activity", "definition": "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O. [UM-BBD_reactionID:r1150]"}
{"concept_id": "C2612989", "aliases": [], "types": ["T044"], "canonical_name": "4,9-DSHA hydrolase activity", "definition": "Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+. [UM-BBD_reactionID:r1152]"}
{"concept_id": "C2612990", "aliases": [], "types": ["T044"], "canonical_name": "citronellol dehydrogenase activity", "definition": "Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+. [UM-BBD_reactionID:r1155]"}
{"concept_id": "C2612991", "aliases": [], "types": ["T044"], "canonical_name": "citronellal dehydrogenase activity", "definition": "Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+. [UM-BBD_reactionID:r1156]"}
{"concept_id": "C2612992", "aliases": [], "types": ["T044"], "canonical_name": "citronellyl-CoA ligase activity", "definition": "Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi. [UM-BBD_reactionID:r1157]"}
{"concept_id": "C2612993", "aliases": [], "types": ["T044"], "canonical_name": "citronellyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+. [UM-BBD_reactionID:r1159]"}
{"concept_id": "C2612994", "aliases": [], "types": ["T044"], "canonical_name": "tetralin ring-hydroxylating dioxygenase activity", "definition": "Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+. [UM-BBD_reactionID:r1169]"}
{"concept_id": "C2612995", "aliases": [], "types": ["T044"], "canonical_name": "1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity", "definition": "Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+. [UM-BBD_reactionID:r1170]"}
{"concept_id": "C2612996", "aliases": [], "types": ["T044"], "canonical_name": "1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity", "definition": "Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+. [UM-BBD_reactionID:r1171]"}
{"concept_id": "C2612997", "aliases": [], "types": ["T044"], "canonical_name": "4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity", "definition": "Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+. [UM-BBD_reactionID:r1172]"}
{"concept_id": "C2612998", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxydec-2,4-diene-1,10-dioate hydratase activity", "definition": "Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate. [UM-BBD_reactionID:r1172]"}
{"concept_id": "C2612999", "aliases": [], "types": ["T044"], "canonical_name": "(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity", "definition": "Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate. [UM-BBD_reactionID:r1174]"}
{"concept_id": "C2613000", "aliases": [], "types": ["T044"], "canonical_name": "(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-. [UM-BBD_reactionID:r1176]"}
{"concept_id": "C2613001", "aliases": [], "types": ["T044"], "canonical_name": "geranial dehydrogenase activity", "definition": "Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+. [UM-BBD_reactionID:r1164]"}
{"concept_id": "C2613002", "aliases": [], "types": ["T044"], "canonical_name": "geranylate CoA-transferase activity", "definition": "Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-. [UM-BBD_reactionID:r1165]"}
{"concept_id": "C2613003", "aliases": [], "types": ["T044"], "canonical_name": "2-mercaptobenzothiazole dioxygenase activity", "definition": "Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol. [UM-BBD_reactionID:r1177]"}
{"concept_id": "C2613004", "aliases": [], "types": ["T044"], "canonical_name": "2-mercaptobenzothiazole monooxygenase activity", "definition": "Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole. [UM-BBD_reactionID:r1178]"}
{"concept_id": "C2613005", "aliases": [], "types": ["T044"], "canonical_name": "6-hydroxy-2-mercaptobenzothiazole monooxygenase activity", "definition": "Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole. [UM-BBD_reactionID:r1181]"}
{"concept_id": "C2613006", "aliases": [], "types": ["T044"], "canonical_name": "2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity", "definition": "Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-. [UM-BBD_reactionID:r1179]"}
{"concept_id": "C2613007", "aliases": [], "types": ["T044"], "canonical_name": "menthone dehydrogenase activity", "definition": "Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+. [UM-BBD_reactionID:r1183]"}
{"concept_id": "C2613008", "aliases": [], "types": ["T044"], "canonical_name": "menth-2-enone hydratase activity", "definition": "Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone. [UM-BBD_reactionID:r1184]"}
{"concept_id": "C2613009", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxymenthone dehydrogenase activity", "definition": "Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+. [UM-BBD_reactionID:r1185]"}
{"concept_id": "C2613010", "aliases": [], "types": ["T044"], "canonical_name": "mentha-1,3-dione-CoA ligase activity", "definition": "Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA. [UM-BBD_reactionID:r1186]"}
{"concept_id": "C2613011", "aliases": [], "types": ["T044"], "canonical_name": "thiophene-2-carboxylate-CoA ligase activity", "definition": "Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi. [UM-BBD_reactionID:r1234]"}
{"concept_id": "C2613012", "aliases": [], "types": ["T044"], "canonical_name": "2-oxoglutaryl-CoA thioesterase activity", "definition": "Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH. [UM-BBD_reactionID:r1238]"}
{"concept_id": "C2613013", "aliases": [], "types": ["T044"], "canonical_name": "naphthyl-2-methyl-succinate CoA-transferase activity", "definition": "Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate. [UM-BBD_reactionID:r1256]"}
{"concept_id": "C2613014", "aliases": [], "types": ["T044"], "canonical_name": "naphthyl-2-methyl-succinyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-. [UM-BBD_reactionID:r1258]"}
{"concept_id": "C2613015", "aliases": [], "types": ["T044"], "canonical_name": "naphthyl-2-methylene-succinyl-CoA lyase activity", "definition": "Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA. [UM-BBD_reactionID:r1259]"}
{"concept_id": "C2613016", "aliases": [], "types": ["T044"], "canonical_name": "naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-. [UM-BBD_reactionID:r1260]"}
{"concept_id": "C2613017", "aliases": [], "types": ["T044"], "canonical_name": "naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity", "definition": "Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA. [UM-BBD_reactionID:r1261]"}
{"concept_id": "C2613018", "aliases": [], "types": ["T044"], "canonical_name": "2-naphthoate CoA-transferase activity", "definition": "Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH. [UM-BBD_reactionID:r1262]"}
{"concept_id": "C2613019", "aliases": [], "types": ["T044"], "canonical_name": "isooctane monooxygenase activity", "definition": "Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol. [UM-BBD_reactionID:r1269]"}
{"concept_id": "C2613020", "aliases": [], "types": ["T044"], "canonical_name": "2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity", "definition": "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA. [UM-BBD_reactionID:r1274]"}
{"concept_id": "C2613021", "aliases": [], "types": ["T044"], "canonical_name": "4,4-dimethyl-3-oxopentanal dehydrogenase activity", "definition": "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-. [UM-BBD_reactionID:r1309]"}
{"concept_id": "C2613022", "aliases": [], "types": ["T044"], "canonical_name": "2,4,4-trimethyl-3-oxopentanoate decarboxylase activity", "definition": "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2. [UM-BBD_reactionID:r1278]"}
{"concept_id": "C2613023", "aliases": [], "types": ["T044"], "canonical_name": "4,4-dimethyl-3-oxopentanoate decarboxylase activity", "definition": "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2. [UM-BBD_reactionID:r1280]"}
{"concept_id": "C2613024", "aliases": [], "types": ["T044"], "canonical_name": "4-AD 9alpha-hydroxylase activity", "definition": "Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O. [UM-BBD_reactionID:r1153]"}
{"concept_id": "C2613025", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyhexa-2,4-dienoate hydratase activity", "definition": "Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate. [UM-BBD_reactionID:r1281]"}
{"concept_id": "C2613026", "aliases": [], "types": ["T044"], "canonical_name": "2-(methylthio)benzothiazole monooxygenase activity", "definition": "Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole. [UM-BBD_reactionID:r1287]"}
{"concept_id": "C2613027", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxybenzothiazole monooxygenase activity", "definition": "Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole. [UM-BBD_reactionID:r1291]"}
{"concept_id": "C2613028", "aliases": [], "types": ["T044"], "canonical_name": "benzothiazole monooxygenase activity", "definition": "Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole. [UM-BBD_reactionID:r1292]"}
{"concept_id": "C2613029", "aliases": [], "types": ["T044"], "canonical_name": "2-mercaptobenzothiazole desulfurase activity", "definition": "Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor. [UM-BBD_reactionID:r1288]"}
{"concept_id": "C2613030", "aliases": [], "types": ["T044"], "canonical_name": "benzothiazole-2-sulfonate hydrolase activity", "definition": "Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-. [UM-BBD_reactionID:r1290]"}
{"concept_id": "C2613031", "aliases": [], "types": ["T044"], "canonical_name": "2,6-dihydroxybenzothiazole monooxygenase activity", "definition": "Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole. [UM-BBD_reactionID:r1294]"}
{"concept_id": "C2613032", "aliases": [], "types": ["T044"], "canonical_name": "2,4,4-trimethyl-1-pentanol dehydrogenase activity", "definition": "Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-. [UM-BBD_reactionID:r1270]"}
{"concept_id": "C2613033", "aliases": [], "types": ["T044"], "canonical_name": "2,4,4-trimethylpentanal dehydrogenase activity", "definition": "Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-. [UM-BBD_reactionID:r1275]"}
{"concept_id": "C2613034", "aliases": [], "types": ["T044"], "canonical_name": "2,4,4-trimethylpentanoate-CoA ligase activity", "definition": "Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-. [UM-BBD_reactionID:r1271]"}
{"concept_id": "C2613035", "aliases": [], "types": ["T044"], "canonical_name": "2,4,4-trimethylpentanoyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-. [UM-BBD_reactionID:r1276]"}
{"concept_id": "C2613036", "aliases": [], "types": ["T044"], "canonical_name": "2,4,4-trimethylpent-2-enoyl-CoA hydratase activity", "definition": "Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA. [UM-BBD_reactionID:r1277]"}
{"concept_id": "C2613037", "aliases": [], "types": ["T044"], "canonical_name": "2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-. [UM-BBD_reactionID:r1273]"}
{"concept_id": "C2613038", "aliases": [], "types": ["T044"], "canonical_name": "2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity", "definition": "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH. [UM-BBD_reactionID:r1307]"}
{"concept_id": "C2613039", "aliases": [], "types": ["T044"], "canonical_name": "pinacolone 5-monooxygenase activity", "definition": "Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one. [UM-BBD_reactionID:r12979]"}
{"concept_id": "C2613040", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity", "definition": "Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-. [UM-BBD_reactionID:r1308]"}
{"concept_id": "C2613041", "aliases": [], "types": ["T044"], "canonical_name": "trans-geranyl-CoA isomerase activity", "definition": "Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA. [UM-BBD_reactionID:r1310]"}
{"concept_id": "C2613042", "aliases": [], "types": ["T044"], "canonical_name": "thioacetamide S-oxygenase activity", "definition": "Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O. [UM-BBD_reactionID:r1312]"}
{"concept_id": "C2613043", "aliases": [], "types": ["T044"], "canonical_name": "thioacetamide S-oxide S-oxygenase activity", "definition": "Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O. [UM-BBD_reactionID:r1313]"}
{"concept_id": "C2613044", "aliases": [], "types": ["T044"], "canonical_name": "caffeine oxidase activity", "definition": "Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O. [RHEA:47148]"}
{"concept_id": "C2613045", "aliases": [], "types": ["T044"], "canonical_name": "isonicotinic acid hydrazide hydrolase activity", "definition": "Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine. [UM-BBD_reactionID:r1336]"}
{"concept_id": "C2613046", "aliases": [], "types": ["T044"], "canonical_name": "isonicotinate dehydrogenase activity", "definition": "Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor. [UM-BBD_reactionID:r1337]"}
{"concept_id": "C2613047", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyisonicotinate dehydrogenase activity", "definition": "Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor. [UM-BBD_reactionID:r1338]"}
{"concept_id": "C2613048", "aliases": [], "types": ["T044"], "canonical_name": "2,3,6-trihydroxyisonicotinate decarboxylase activity", "definition": "Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2. [UM-BBD_reactionID:r1340]"}
{"concept_id": "C2613049", "aliases": [], "types": ["T044"], "canonical_name": "citrazinate dehydrogenase activity", "definition": "Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-. [UM-BBD_reactionID:r1339]"}
{"concept_id": "C2613050", "aliases": [], "types": ["T044"], "canonical_name": "citrazinate hydrolase activity", "definition": "Catalysis of the reaction: citrazinate + H2O = cis-aconitamide. [UM-BBD_reactionID:r1343]"}
{"concept_id": "C2613051", "aliases": [], "types": ["T044"], "canonical_name": "cis-aconitamide amidase activity", "definition": "Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3. [UM-BBD_reactionID:r1344]"}
{"concept_id": "C2613054", "aliases": [], "types": ["T044"], "canonical_name": "gamma-N-formylaminovinylacetate hydrolase activity", "definition": "Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH. [UM-BBD_reactionID:r1350]"}
{"concept_id": "C2613055", "aliases": [], "types": ["T044"], "canonical_name": "gamma-aminovinylacetate deaminase activity", "definition": "Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3. [UM-BBD_reactionID:r1351]"}
{"concept_id": "C2613057", "aliases": [], "types": ["T044"], "canonical_name": "endosulfan monooxygenase I activity", "definition": "Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O. [UM-BBD_reactionID:r1382]"}
{"concept_id": "C2613058", "aliases": [], "types": ["T044"], "canonical_name": "endosulfan hemisulfate sulfatase activity", "definition": "Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate. [UM-BBD_reactionID:r1384]"}
{"concept_id": "C2613059", "aliases": [], "types": ["T044"], "canonical_name": "endosulfan diol hydrolyase (cyclizing) activity", "definition": "Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O. [UM-BBD_reactionID:r1386]"}
{"concept_id": "C2613060", "aliases": [], "types": ["T044"], "canonical_name": "endosulfan diol dehydrogenase activity", "definition": "Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-. [UM-BBD_reactionID:r1388]"}
{"concept_id": "C2613061", "aliases": [], "types": ["T044"], "canonical_name": "endosulfan lactone lactonase activity", "definition": "Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+. [UM-BBD_reactionID:r1389]"}
{"concept_id": "C2613062", "aliases": [], "types": ["T044"], "canonical_name": "N-nitrodimethylamine hydroxylase activity", "definition": "Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O. [UM-BBD_reactionID:r1395]"}
{"concept_id": "C2613063", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxypyridine-3-hydroxylase activity", "definition": "Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+. [UM-BBD_reactionID:r1397]"}
{"concept_id": "C2613064", "aliases": [], "types": ["T044"], "canonical_name": "pyridine-3,4-diol dioxygenase activity", "definition": "Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate. [UM-BBD_reactionID:r1398]"}
{"concept_id": "C2613065", "aliases": [], "types": ["T044"], "canonical_name": "3-formiminopyruvate hydrolase activity", "definition": "Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3. [UM-BBD_reactionID:r1400]"}
{"concept_id": "C2613066", "aliases": [], "types": ["T044"], "canonical_name": "4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity", "definition": "Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol. [UM-BBD_reactionID:r1358]"}
{"concept_id": "C2613067", "aliases": [], "types": ["T044"], "canonical_name": "hexadecyltrimethylammonium chloride monooxygenase activity", "definition": "Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O. [UM-BBD_reactionID:r1373]"}
{"concept_id": "C2613068", "aliases": [], "types": ["T044"], "canonical_name": "trimethylamine monooxygenase activity", "definition": "Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O. [EC:1.14.13.148, UM-BBD_reactionID:r1407]"}
{"concept_id": "C2613069", "aliases": [], "types": ["T044"], "canonical_name": "3-(N-formyl)-formiminopyruvate hydrolase activity", "definition": "Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate. [UM-BBD_reactionID:r1399]"}
{"concept_id": "C2613070", "aliases": [], "types": ["T044"], "canonical_name": "endosulfan hydroxyether dehydrogenase activity", "definition": "Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-. [UM-BBD_reactionID:r1411]"}
{"concept_id": "C2613071", "aliases": [], "types": ["T044"], "canonical_name": "endosulfan sulfate hydrolase activity", "definition": "Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite. [UM-BBD_reactionID:r1387]"}
{"concept_id": "C2613072", "aliases": [], "types": ["T044"], "canonical_name": "endosulfan ether monooxygenase activity", "definition": "Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O. [UM-BBD_reactionID:r1413]"}
{"concept_id": "C2613073", "aliases": [], "types": ["T044"], "canonical_name": "5-chloro-2-oxopent-4-enoate hydratase activity", "definition": "Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate. [UM-BBD_reactionID:r1436]"}
{"concept_id": "C2613074", "aliases": [], "types": ["T044"], "canonical_name": "5-chloro-4-hydroxy-2-oxopentanate aldolase activity", "definition": "Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde. [UM-BBD_reactionID:r1437]"}
{"concept_id": "C2613075", "aliases": [], "types": ["T044"], "canonical_name": "N-isopropylaniline 1,2-dixoxygenase activity", "definition": "Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine. [UM-BBD_reactionID:r0721]"}
{"concept_id": "C2613076", "aliases": [], "types": ["T044"], "canonical_name": "acetanilide 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide. [UM-BBD_reactionID:r0723]"}
{"concept_id": "C2613077", "aliases": [], "types": ["T044"], "canonical_name": "2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+. [UM-BBD_reactionID:r0724]"}
{"concept_id": "C2613078", "aliases": [], "types": ["T044"], "canonical_name": "6-hydroxypseudooxynicotine dehydrogenase activity", "definition": "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine. [UM-BBD_reactionID:r1441]"}
{"concept_id": "C2613079", "aliases": [], "types": ["T044"], "canonical_name": "6-hydroxy-3-succinoylpyridine hydrolase activity", "definition": "Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine. [UM-BBD_reactionID:r1442]"}
{"concept_id": "C2613080", "aliases": [], "types": ["T044"], "canonical_name": "phthalate 3,4-dioxygenase activity", "definition": "Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+. [UM-BBD_reactionID:r1444]"}
{"concept_id": "C2613081", "aliases": [], "types": ["T044"], "canonical_name": "phthalate 3,4-cis-dihydrodiol dehydrogenase activity", "definition": "Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+. [UM-BBD_reactionID:r1445]"}
{"concept_id": "C2613083", "aliases": ["2,4,6-trinitrophenol hydride denitratase activity", "TNP hydride denitratase activity"], "types": ["T044"], "canonical_name": "trinitrophenol hydride denitratase activity", "definition": "Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP. [UM-BBD_reactionID:r1448]"}
{"concept_id": "C2613084", "aliases": [], "types": ["T044"], "canonical_name": "2-methylhexanoyl-CoA C-acetyltransferase activity", "definition": "Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA. [UM-BBD_reactionID:r0927]"}
{"concept_id": "C2613085", "aliases": [], "types": ["T044"], "canonical_name": "2-methylhexanoyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-. [UM-BBD_reactionID:r0928]"}
{"concept_id": "C2613086", "aliases": [], "types": ["T044"], "canonical_name": "2-methylhex-2-enoyl-CoA hydratase activity", "definition": "Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA. [UM-BBD_reactionID:r0929]"}
{"concept_id": "C2613087", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-. [UM-BBD_reactionID:r0930]"}
{"concept_id": "C2613088", "aliases": [], "types": ["T044"], "canonical_name": "butyryl-CoA 2-C-propionyltransferase activity", "definition": "Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA. [UM-BBD_reactionID:r0931]"}
{"concept_id": "C2613089", "aliases": [], "types": ["T044"], "canonical_name": "pyrene dioxygenase activity", "definition": "Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene. [UM-BBD_reactionID:r0934]"}
{"concept_id": "C2613090", "aliases": [], "types": ["T044"], "canonical_name": "cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity", "definition": "Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-. [UM-BBD_reactionID:r0935]"}
{"concept_id": "C2613091", "aliases": [], "types": ["T044"], "canonical_name": "4,5-dihydroxypyrene dioxygenase activity", "definition": "Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+. [UM-BBD_reactionID:r0936]"}
{"concept_id": "C2613092", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene-4,5-dicarboxylate decarboxylase activity", "definition": "Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2. [UM-BBD_reactionID:r0937]"}
{"concept_id": "C2613093", "aliases": [], "types": ["T044"], "canonical_name": "cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity", "definition": "Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2. [UM-BBD_reactionID:r0940]"}
{"concept_id": "C2613094", "aliases": [], "types": ["T044"], "canonical_name": "pyrene 4,5-monooxygenase activity", "definition": "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O. [UM-BBD_reactionID:r0941]"}
{"concept_id": "C2613095", "aliases": [], "types": ["T044"], "canonical_name": "pyrene-4,5-epoxide hydrolase activity", "definition": "Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene. [UM-BBD_reactionID:r0942]"}
{"concept_id": "C2613096", "aliases": [], "types": ["T044"], "canonical_name": "pyrene 1,2-monooxygenase activity", "definition": "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O. [UM-BBD_reactionID:r0943]"}
{"concept_id": "C2613097", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxypyrene 6,7-monooxygenase activity", "definition": "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O. [UM-BBD_reactionID:r0946]"}
{"concept_id": "C2613098", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxypyrene 7,8-monooxygenase activity", "definition": "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O. [UM-BBD_reactionID:r0949]"}
{"concept_id": "C2613099", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxypyrene sulfotransferase activity", "definition": "Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX. [UM-BBD_reactionID:r0952]"}
{"concept_id": "C2613100", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxypyrene methyltransferase activity", "definition": "Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX. [UM-BBD_reactionID:r0953]"}
{"concept_id": "C2613101", "aliases": [], "types": ["T044"], "canonical_name": "1-methoxypyrene 6,7-monooxygenase activity", "definition": "Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O. [UM-BBD_reactionID:r0954]"}
{"concept_id": "C2613102", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxy-6-methoxypyrene methyltransferase activity", "definition": "Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX. [UM-BBD_reactionID:r0956]"}
{"concept_id": "C2613103", "aliases": [], "types": ["T044"], "canonical_name": "phenanthrene-4-carboxylate dioxygenase activity", "definition": "Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate. [UM-BBD_reactionID:r0939]"}
{"concept_id": "C2613104", "aliases": [], "types": ["T044"], "canonical_name": "tetrachlorobenzene dioxygenase activity", "definition": "Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+. [UM-BBD_reactionID:r0957]"}
{"concept_id": "C2613105", "aliases": [], "types": ["T044"], "canonical_name": "4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+. [UM-BBD_reactionID:r0959]"}
{"concept_id": "C2613106", "aliases": [], "types": ["T044"], "canonical_name": "perchlorate reductase activity", "definition": "Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O. [UM-BBD_reactionID:r0980]"}
{"concept_id": "C2613107", "aliases": [], "types": ["T044"], "canonical_name": "pyrrole-2-carboxylate monooxygenase activity", "definition": "Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O. [UM-BBD_reactionID:r0968]"}
{"concept_id": "C2613108", "aliases": [], "types": ["T044"], "canonical_name": "5-hydroxypyrrole-2-carboxylate tautomerase activity", "definition": "Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate. [UM-BBD_reactionID:r0969]"}
{"concept_id": "C2613109", "aliases": [], "types": ["T044"], "canonical_name": "5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity", "definition": "Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3. [UM-BBD_reactionID:r0984]"}
{"concept_id": "C2613110", "aliases": [], "types": ["T044"], "canonical_name": "pyrrole-2-carboxylate decarboxylase activity", "definition": "Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2. [UM-BBD_reactionID:r0970]"}
{"concept_id": "C2613111", "aliases": [], "types": ["T044"], "canonical_name": "cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity", "definition": "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi. [UM-BBD_reactionID:r0988]"}
{"concept_id": "C2613112", "aliases": [], "types": ["T044"], "canonical_name": "trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity", "definition": "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi. [UM-BBD_reactionID:r0989]"}
{"concept_id": "C2613113", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+. [UM-BBD_reactionID:r0986]"}
{"concept_id": "C2613114", "aliases": [], "types": ["T044"], "canonical_name": "2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity", "definition": "Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA. [UM-BBD_reactionID:r0987]"}
{"concept_id": "C2613115", "aliases": [], "types": ["T044"], "canonical_name": "3-isopropylbut-3-enoyl-CoA thioesterase activity", "definition": "Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH. [UM-BBD_reactionID:r0994]"}
{"concept_id": "C2613116", "aliases": [], "types": ["T044"], "canonical_name": "terephthalate decarboxylase activity", "definition": "Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-. [UM-BBD_reactionID:r0321]"}
{"concept_id": "C2613117", "aliases": [], "types": ["T044"], "canonical_name": "2,6-dihydroxypseudooxynicotine hydrolase activity", "definition": "Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate. [UM-BBD_reactionID:r0482]"}
{"concept_id": "C2613118", "aliases": [], "types": ["T044"], "canonical_name": "1,1-dichloroethane reductive dehalogenase activity", "definition": "Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl. [UM-BBD_reactionID:r1008]"}
{"concept_id": "C2613119", "aliases": [], "types": ["T044"], "canonical_name": "phenylboronic acid monooxygenase activity", "definition": "Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3. [UM-BBD_reactionID:r1020]"}
{"concept_id": "C2613120", "aliases": [], "types": ["T044"], "canonical_name": "o-hydroxylaminobenzoate mutase activity", "definition": "Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate. [UM-BBD_reactionID:r1026]"}
{"concept_id": "C2613121", "aliases": [], "types": ["T044"], "canonical_name": "malonate semialdehyde decarboxylase activity", "definition": "Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2. [UM-BBD_reactionID:r0266]"}
{"concept_id": "C2613122", "aliases": [], "types": ["T044"], "canonical_name": "perillyl-CoA hydratase activity", "definition": "Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA. [UM-BBD_reactionID:r1002]"}
{"concept_id": "C2613123", "aliases": [], "types": ["T044"], "canonical_name": "diphenyl ether 2,3-dioxygenase activity", "definition": "Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether. [UM-BBD_reactionID:r1450]"}
{"concept_id": "C2613124", "aliases": [], "types": ["T044"], "canonical_name": "2,3-dihydroxydiphenyl ether dioxygenase activity", "definition": "Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol. [UM-BBD_reactionID:r1451]"}
{"concept_id": "C2613125", "aliases": [], "types": ["T044"], "canonical_name": "diphenyl ether 1,2-dioxygenase activity", "definition": "Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+. [UM-BBD_reactionID:r1453]"}
{"concept_id": "C2613126", "aliases": [], "types": ["T044"], "canonical_name": "3-nitrophenol nitroreductase activity", "definition": "Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O. [UM-BBD_reactionID:r1495]"}
{"concept_id": "C2613128", "aliases": [], "types": ["T044"], "canonical_name": "endothelin maturation", "definition": "The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2613132", "aliases": [], "types": ["T045"], "canonical_name": "box C/D snoRNA processing"}
{"concept_id": "C2613133", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA snoRNA processing"}
{"concept_id": "C2613134", "aliases": [], "types": ["T045"], "canonical_name": "intronic box C/D snoRNA processing"}
{"concept_id": "C2613135", "aliases": [], "types": ["T045"], "canonical_name": "intronic box H/ACA snoRNA processing", "definition": "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA. [GOC:mah]"}
{"concept_id": "C2613136", "aliases": ["SET3C", "Set3 complex location", "HDAC3 complex location", "HDAC3 complex"], "types": ["T026"], "canonical_name": "Set3 complex", "definition": "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p. [GOC:ds, PMID:11711434]"}
{"concept_id": "C2613137", "aliases": [], "types": ["T044"], "canonical_name": "histone lysine methylation", "definition": "The modification of a histone by addition of one or more methyl groups to a lysine residue. [GOC:mah, GOC:pr]"}
{"concept_id": "C2613138", "aliases": [], "types": ["T044"], "canonical_name": "histone arginine methylation", "definition": "The modification of a histone by addition of a methyl group to an arginine residue. [GOC:mah]"}
{"concept_id": "C2613139", "aliases": ["histone lysine H3 R2 methylation", "histone H3R2me", "histone H3 R2 methylation"], "types": ["T044"], "canonical_name": "histone H3-R2 methylation", "definition": "The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone. [GOC:mah]"}
{"concept_id": "C2613140", "aliases": ["histone H3R17me", "histone lysine H3 R17 methylation", "histone H3 R17 methylation"], "types": ["T044"], "canonical_name": "histone H3-R17 methylation", "definition": "The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone. [GOC:mah]"}
{"concept_id": "C2613141", "aliases": ["histone H3 R26 methylation", "histone lysine H3 R26 methylation", "histone H3R26me"], "types": ["T044"], "canonical_name": "histone H3-R26 methylation", "definition": "The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone. [GOC:mah]"}
{"concept_id": "C2613142", "aliases": ["Sid2-Mob1 complex location", "Dbf2p-Mob1p complex location", "Sid2-Mob1 kinase complex location", "Dbf2p-Mob1p complex", "Sid2p-Mob1p complex", "Sid2p-Mob1p complex location", "Sid2-Mob1 kinase complex"], "types": ["T026"], "canonical_name": "Sid2-Mob1 complex", "definition": "A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex. [GOC:vw, PMID:10837231, PMID:15060149]"}
{"concept_id": "C2613143", "aliases": ["Swi5-Swi2 complex location"], "types": ["T026"], "canonical_name": "Swi5-Swi2 complex", "definition": "A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching. [PMID:14663140]"}
{"concept_id": "C2613144", "aliases": ["protein folding in ER", "oxidative protein folding"], "types": ["T044"], "canonical_name": "protein folding in endoplasmic reticulum", "definition": "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). [GOC:mah, GOC:vw]"}
{"concept_id": "C2613145", "aliases": ["ER stress response", "cellular response to endoplasmic reticulum stress", "response to ER stress"], "types": ["T043"], "canonical_name": "response to endoplasmic reticulum stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:cjm, GOC:mah]"}
{"concept_id": "C2613146", "aliases": ["ABIN2-NFKB1-TPL-1 complex location", "ABIN2-NFKB1-TPL-1 complex", "ABIN2-NFKB1-MAP3K8 complex location"], "types": ["T026"], "canonical_name": "ABIN2-NFKB1-MAP3K8 complex", "definition": "A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages. [PMID:15169888]"}
{"concept_id": "C2613147", "aliases": ["acinar cell-specific C complex location", "PDX1-PBX1b-MRG1 complex location", "acinar cell-specific C complex"], "types": ["T026"], "canonical_name": "PDX1-PBX1b-MRG1 complex", "definition": "A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes. [PMID:11279116, PMID:9710595]"}
{"concept_id": "C2613148", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent protein deacetylase activity", "definition": "Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. [GOC:BHF, GOC:mah, PMID:28450737]"}
{"concept_id": "C2613149", "aliases": ["FHL2-CREB complex location"], "types": ["T026"], "canonical_name": "FHL2-CREB complex", "definition": "A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation. [PMID:11046156]"}
{"concept_id": "C2613150", "aliases": ["FHL3-CREB complex location"], "types": ["T026"], "canonical_name": "FHL3-CREB complex", "definition": "A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation. [PMID:11046156]"}
{"concept_id": "C2613151", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial protein processing", "definition": "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. [GOC:curators]"}
{"concept_id": "C2613152", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial protein modification"}
{"concept_id": "C2613153", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine deacetylation", "definition": "The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2613154", "aliases": [], "types": ["T044"], "canonical_name": "protein lysine acetylation"}
{"concept_id": "C2613156", "aliases": ["Ecsit-NDUFAF1 complex location"], "types": ["T026"], "canonical_name": "Ecsit-NDUFAF1 complex", "definition": "Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed. [PMID:17344420]"}
{"concept_id": "C2613157", "aliases": [], "types": ["T044"], "canonical_name": "iron chaperone activity", "definition": "Directly binding to and delivering iron ions to a target protein. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2613158", "aliases": [], "types": ["T044"], "canonical_name": "immunoglobulin receptor binding", "definition": "Binding to one or more specific sites on an immunoglobulin receptor molecule. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2613159", "aliases": [], "types": ["T044"], "canonical_name": "Fc receptor binding"}
{"concept_id": "C2613160", "aliases": [], "types": ["T044"], "canonical_name": "Fc-gamma receptor I complex binding", "definition": "Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2613162", "aliases": ["nuclear mitotic cohesin complex location"], "types": ["T026"], "canonical_name": "nuclear mitotic cohesin complex", "definition": "A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. [GOC:mah]"}
{"concept_id": "C2613163", "aliases": ["nuclear meiotic cohesin complex location"], "types": ["T026"], "canonical_name": "nuclear meiotic cohesin complex", "definition": "A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex. [GOC:mah]"}
{"concept_id": "C2613164", "aliases": ["LINC complex location", "LINC complex", "meiotic nuclear membrane microtubule tethering complex", "LInker of Nucleoskeleton and Cytoskeleton complex location", "SUN-KASH complex location", "meiotic nuclear membrane microtubule tethering complex location", "SUN-KASH complex"], "types": ["T026"], "definition": "A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis. [GOC:mah, PMID:18692466]", "canonical_name": "LInker of Nucleoskeleton and Cytoskeleton complex"}
{"concept_id": "C2613165", "aliases": ["MTOC attachment site organization", "MAS organization", "microtubule organising centre attachment site organisation"], "types": ["T043"], "canonical_name": "microtubule organizing center attachment site organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches. [GOC:mah, PMID:18692466]"}
{"concept_id": "C2613166", "aliases": ["SC5b-7 complex location"], "types": ["T026"], "canonical_name": "SC5b-7 complex", "definition": "A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly. [PMID:10090939]"}
{"concept_id": "C2613167", "aliases": ["RasGAP-Fyn-Lyn-Yes complex location"], "types": ["T026"], "canonical_name": "RasGAP-Fyn-Lyn-Yes complex", "definition": "A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation. [PMID:1544885]"}
{"concept_id": "C2613168", "aliases": ["p21(ras)GAP-Fyn-Lyn-Yes complex location, thrombin stimulated"], "types": ["T026"], "canonical_name": "p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated"}
{"concept_id": "C2613169", "aliases": ["alphav-beta5 integrin-vitronectin complex location"], "types": ["T026"], "canonical_name": "alphav-beta5 integrin-vitronectin complex", "definition": "A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin. [PMID:1694173]"}
{"concept_id": "C2613170", "aliases": ["ITGAV-ITGB5-VTN complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB5-VTN complex"}
{"concept_id": "C2613171", "aliases": ["oligosaccharyltransferase I complex location", "OSTCI"], "types": ["T026"], "canonical_name": "oligosaccharyltransferase I complex", "definition": "An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes. [PMID:15835887]"}
{"concept_id": "C2613172", "aliases": ["oligosaccharyltransferase II complex location", "OSTCII"], "types": ["T026"], "canonical_name": "oligosaccharyltransferase II complex", "definition": "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes. [GOC:BHF, PMID:15835887]"}
{"concept_id": "C2613173", "aliases": ["OSTCIII", "oligosaccharyltransferase III complex location"], "types": ["T026"], "canonical_name": "oligosaccharyltransferase III complex", "definition": "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes. [PMID:15835887]"}
{"concept_id": "C2613175", "aliases": ["cilium axoneme assembly", "flagellum axoneme assembly", "ciliary axoneme assembly", "flagellar axoneme assembly"], "types": ["T044"], "canonical_name": "axoneme assembly", "definition": "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]"}
{"concept_id": "C2613190", "aliases": [], "types": ["T043"], "canonical_name": "cytoneme assembly", "definition": "Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell. [PMID:10367889, PMID:10675901]"}
{"concept_id": "C2613191", "aliases": ["type I protein arginine methyltransferase activity"], "types": ["T044"], "canonical_name": "type I PRMT activity"}
{"concept_id": "C2613192", "aliases": ["type II protein arginine methyltransferase activity"], "types": ["T044"], "canonical_name": "type II PRMT activity"}
{"concept_id": "C2613193", "aliases": ["pre-microRNA export from nucleus", "pre-microRNA export from cell nucleus", "pre-microRNA-nucleus export", "pre-microRNA export out of nucleus", "pre-microRNA transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "pre-miRNA export from nucleus", "definition": "Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product. [GOC:sl, PMID:14744438]"}
{"concept_id": "C2613198", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sporulation resulting in formation of a cellular spore", "definition": "Any process that modulates the frequency, rate or extent of spore formation. [GOC:jl]"}
{"concept_id": "C2613199", "aliases": [], "types": ["T044"], "canonical_name": "heparin N-acetylglucosaminyltransferase activity"}
{"concept_id": "C2613212", "aliases": ["cardiac jogging"], "types": ["T042"], "canonical_name": "heart jogging", "definition": "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis. [GOC:mtg_heart, PMID:9334285]"}
{"concept_id": "C2613213", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytokine mediated signaling pathway"}
{"concept_id": "C2613214", "aliases": [], "types": ["T044"], "canonical_name": "activation of cytokine mediated signaling pathway"}
{"concept_id": "C2613215", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of cytokine mediated signaling pathway"}
{"concept_id": "C2613216", "aliases": [], "types": ["T043"], "canonical_name": "ocellus photoreceptor cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus. [GOC:go_curators]"}
{"concept_id": "C2613217", "aliases": [], "types": ["T043"], "canonical_name": "ocellus photoreceptor cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. [GOC:mtg_sensu]"}
{"concept_id": "C2613218", "aliases": [], "types": ["T026"], "canonical_name": "plasma membrane-derived chromatophore", "definition": "A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria. [GOC:jl, ISBN:0395825172, PMID:11867431]"}
{"concept_id": "C2613219", "aliases": [], "types": ["T026"], "canonical_name": "plasma membrane-derived chromatophore membrane", "definition": "The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles. [GOC:jl, GOC:mah, ISBN:0395825172, PMID:11867431]"}
{"concept_id": "C2613221", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial ATP synthesis coupled electron transport", "definition": "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane. [GOC:mtg_sensu, ISBN:0716731363]"}
{"concept_id": "C2613222", "aliases": ["laminarinase activity", "laminaranase activity"], "types": ["T044"], "canonical_name": "laminaranase activity"}
{"concept_id": "C2613223", "aliases": ["tyrosine phosphorylation of JAK protein", "activation of JAK protein by tyrosine phosphorylation", "activation of JAK protein", "positive regulation of JAK protein activity by tyrosine phosphorylation"], "types": ["T044"], "canonical_name": "activation of Janus kinase activity", "definition": "The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. [GOC:jl, PMID:12479803]"}
{"concept_id": "C2613224", "aliases": [], "types": ["T044"], "canonical_name": "amino acid activation for nonribosomal peptide biosynthetic process", "definition": "Activation of an amino acid for incorporation into a peptide by a nonribosomal process. [GOC:jl]"}
{"concept_id": "C2613225", "aliases": [], "types": ["T043"], "canonical_name": "cellular metabolic compound salvage", "definition": "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. [GOC:mlg]"}
{"concept_id": "C2613231", "aliases": [], "types": ["T044"], "canonical_name": "heparin proteoglycan binding"}
{"concept_id": "C2613232", "aliases": [], "types": ["T026"], "canonical_name": "perispore"}
{"concept_id": "C2613233", "aliases": ["Tpg-containing telomere binding complex location"], "types": ["T026"], "canonical_name": "Tpg-containing telomere binding complex", "definition": "A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species. [PMID:15353591]"}
{"concept_id": "C2613234", "aliases": ["thrH"], "types": ["T044"], "canonical_name": "phosphoserine:homoserine phosphotransferase activity", "definition": "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine. [GOC:jl, PMID:14699121]"}
{"concept_id": "C2613238", "aliases": [], "types": ["T038"], "canonical_name": "regulation of symbiosis, encompassing mutualism through parasitism"}
{"concept_id": "C2613239", "aliases": ["isochorismate-pyruvate lyase activity", "isochorismate pyruvate lyase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: isochorismate = salicylate + pyruvate. [GOC:jl, PMID:16248620]", "canonical_name": "IPL"}
{"concept_id": "C2613240", "aliases": ["Ser-tRNAThr hydrolase activity"], "types": ["T044"], "canonical_name": "Ser-tRNA(Thr) hydrolase activity", "definition": "Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr). [GOC:jl, PMID:15240874]"}
{"concept_id": "C2613241", "aliases": ["Ala-tRNAPro hydrolase activity"], "types": ["T044"], "canonical_name": "Ala-tRNA(Pro) hydrolase activity", "definition": "Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro). [GOC:jl, PMID:14663147]"}
{"concept_id": "C2613242", "aliases": ["Cys-tRNAPro hydrolase activity", "Cys-tRNA(Pro) deacetylase activity"], "types": ["T044"], "canonical_name": "Cys-tRNA(Pro) hydrolase activity", "definition": "Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro). [GOC:jl, PMID:15886196]"}
{"concept_id": "C2613243", "aliases": ["Ser(Gly)-tRNAAla hydrolase activity"], "types": ["T044"], "canonical_name": "Ser(Gly)-tRNA(Ala) hydrolase activity", "definition": "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala). [GOC:jl, PMID:14663147]"}
{"concept_id": "C2613244", "aliases": ["N-acetyl-L-citrulline deacetylase activity", "acetylcitrulline deacetylase activity"], "types": ["T044"], "canonical_name": "N-acetylcitrulline deacetylase activity", "definition": "Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate. [GOC:jl, PMID:16750290, RHEA:61092]"}
{"concept_id": "C2613245", "aliases": ["coenzyme F390-A synthetase activity", "ATP:coenzyme F420 adenyltransferase activity"], "types": ["T044"], "canonical_name": "ATP:coenzyme F420 adenylyltransferase activity", "definition": "Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate. [GOC:jl, MetaCyc:RXN-9385, PMID:7957247, PMID:8550473]"}
{"concept_id": "C2613246", "aliases": ["D-lysine aminotransferase activity"], "types": ["T044"], "canonical_name": "D-lysine transaminase activity", "definition": "Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate. [GOC:jl, PMID:17259313]"}
{"concept_id": "C2613247", "aliases": [], "types": ["T044"], "canonical_name": "D-lysine oxidase activity", "definition": "Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide. [GOC:jl, PMID:17259313]"}
{"concept_id": "C2613250", "aliases": ["O-phosphoseryl-tRNA(Sec) kinase activity"], "types": ["T044"], "canonical_name": "L-seryl-tRNA(Sec) kinase activity", "definition": "Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec). [GOC:jl, PMID:16201757, RHEA:25037]"}
{"concept_id": "C2613251", "aliases": [], "types": ["T045"], "canonical_name": "DNA-7-methylguanine glycosylase activity", "definition": "Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site. [GOC:jl, PMID:16468998]"}
{"concept_id": "C2613252", "aliases": ["ribose-1,5-bisphosphate isomerase activity"], "types": ["T044"], "canonical_name": "ribose 1,5-bisphosphate isomerase activity", "definition": "Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate. [GOC:jl]"}
{"concept_id": "C2613253", "aliases": ["cadaverine aminopropyl transferase activity"], "types": ["T044"], "canonical_name": "cadaverine aminopropyltransferase activity", "definition": "Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine. [GOC:jl, PMID:17545282]"}
{"concept_id": "C2613254", "aliases": ["agmatine aminopropyl transferase activity"], "types": ["T044"], "canonical_name": "agmatine aminopropyltransferase activity", "definition": "Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine. [GOC:jl, PMID:15983049]"}
{"concept_id": "C2613255", "aliases": [], "types": ["T044"], "canonical_name": "aminopropylagmatine ureohydrolase activity", "definition": "Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea. [GOC:jl, PMID:15983049, RHEA:35827]"}
{"concept_id": "C2613256", "aliases": ["regulation by host of viral transcription", "regulation of viral transcription by host"], "types": ["T043"], "canonical_name": "modulation by host of viral transcription", "definition": "Any process in which a host organism modulates the frequency, rate or extent of viral transcription. [GOC:jl]"}
{"concept_id": "C2613257", "aliases": ["negative regulation of viral transcription by host"], "types": ["T045"], "canonical_name": "negative regulation by host of viral transcription", "definition": "Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription. [GOC:jl]"}
{"concept_id": "C2613258", "aliases": ["positive regulation of viral transcription by host"], "types": ["T043"], "canonical_name": "positive regulation by host of viral transcription", "definition": "Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. [GOC:jl]"}
{"concept_id": "C2613259", "aliases": ["Germanin binding"], "types": ["T044"], "canonical_name": "suramin binding", "definition": "Binding to suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms. [GOC:jl, Wikipedia:Suramin]"}
{"concept_id": "C2613260", "aliases": [], "types": ["T045"], "canonical_name": "exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay", "definition": "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap. [GOC:mtg_mpo]"}
{"concept_id": "C2613261", "aliases": [], "types": ["T045"], "canonical_name": "exonucleolytic catabolism of deadenylated mRNA", "definition": "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail. [GOC:mtg_mpo]"}
{"concept_id": "C2613262", "aliases": [], "types": ["T042"], "canonical_name": "primary ovarian follicle growth during double layer follicle stage"}
{"concept_id": "C2613263", "aliases": [], "types": ["T042"], "canonical_name": "primary ovarian follicle growth during primary follicle stage"}
{"concept_id": "C2613264", "aliases": ["ossification involved in skeletal development"], "types": ["T042"], "canonical_name": "ossification involved in bone maturation", "definition": "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. [GOC:dph, GOC:mah, GOC:mtg_mpo]"}
{"concept_id": "C2613265", "aliases": ["ossification involved in bone remodelling"], "types": ["T042"], "canonical_name": "ossification involved in bone remodeling", "definition": "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli. [GO_REF:0000034, GOC:mtg_mpo]"}
{"concept_id": "C2613266", "aliases": ["macromolecular complex organization", "cellular macromolecular complex subunit organisation", "cellular macromolecular complex subunit organization", "cellular macromolecular complex organization", "macromolecular complex subunit organisation"], "types": ["T043"], "canonical_name": "macromolecular complex subunit organization"}
{"concept_id": "C2613267", "aliases": [], "types": ["T043"], "definition": "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. [GOC:pamgo_curators]", "canonical_name": "sporulation"}
{"concept_id": "C2613268", "aliases": [], "types": ["T043"], "canonical_name": "sexual sporulation resulting in formation of a cellular spore", "definition": "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. [GOC:pamgo_curators]"}
{"concept_id": "C2613269", "aliases": ["asexual reproduction resulting in the formation of a cellular spore"], "types": ["T043"], "canonical_name": "asexual sporulation resulting in formation of a cellular spore", "definition": "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. [GOC:pamgo_curators]"}
{"concept_id": "C2613270", "aliases": [], "types": ["T038"], "canonical_name": "regulation of sporulation", "definition": "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. [GOC:pamgo_curators]"}
{"concept_id": "C2613271", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of sporulation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. [GOC:pamgo_curators]"}
{"concept_id": "C2613272", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of sporulation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. [GOC:pamgo_curators]"}
{"concept_id": "C2613273", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sexual sporulation resulting in formation of a cellular spore", "definition": "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis. [GOC:pamgo_curators]"}
{"concept_id": "C2613274", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of sexual sporulation resulting in formation of a cellular spore", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis. [GOC:pamgo_curators]"}
{"concept_id": "C2613275", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of sexual sporulation resulting in formation of a cellular spore", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis. [GOC:pamgo_curators]"}
{"concept_id": "C2613276", "aliases": [], "types": ["T043"], "canonical_name": "regulation of asexual sporulation resulting in formation of a cellular spore", "definition": "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis. [GOC:pamgo_curators]"}
{"concept_id": "C2613277", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of asexual sporulation resulting in formation of a cellular spore", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis. [GOC:pamgo_curators]"}
{"concept_id": "C2613278", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of asexual sporulation resulting in formation of a cellular spore", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis. [GOC:pamgo_curators]"}
{"concept_id": "C2613288", "aliases": ["regulation of cAMP-mediated signalling"], "types": ["T044"], "canonical_name": "regulation of cAMP-mediated signaling", "definition": "Any process which modulates the frequency, rate or extent of cAMP-mediated signaling. [GOC:jl]"}
{"concept_id": "C2613289", "aliases": ["positive regulation of cAMP-mediated signalling"], "types": ["T044"], "canonical_name": "positive regulation of cAMP-mediated signaling", "definition": "Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling. [GOC:jl]"}
{"concept_id": "C2613290", "aliases": ["negative regulation of cAMP-mediated signalling"], "types": ["T044"], "canonical_name": "negative regulation of cAMP-mediated signaling", "definition": "Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling. [GOC:jl]"}
{"concept_id": "C2613291", "aliases": [], "types": ["T043"], "canonical_name": "protein transport by the Sec complex", "definition": "The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide. [GOC:pamgo_curators]"}
{"concept_id": "C2613292", "aliases": [], "types": ["T043"], "canonical_name": "protein secretion by the Sec complex"}
{"concept_id": "C2613293", "aliases": [], "types": ["T043"], "canonical_name": "protein translocation by the Sec complex"}
{"concept_id": "C2613294", "aliases": ["twin-arginine translocation pathway"], "types": ["T043"], "canonical_name": "protein transport by the Tat complex", "definition": "The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. [GOC:pamgo_curators]"}
{"concept_id": "C2613295", "aliases": [], "types": ["T043"], "canonical_name": "protein secretion by the TAT complex"}
{"concept_id": "C2613296", "aliases": [], "types": ["T043"], "canonical_name": "protein translocation by the TAT complex"}
{"concept_id": "C2613297", "aliases": [], "types": ["T043"], "canonical_name": "protein translocation by the twin-arginine translocation complex"}
{"concept_id": "C2613298", "aliases": ["cellular component maintenance at cellular level"], "types": ["T043"], "canonical_name": "cellular component maintenance", "definition": "The organization process that preserves a cellular component in a stable functional or structural state. [GOC:dph, GOC:jl, GOC:mah]"}
{"concept_id": "C2613299", "aliases": ["3-hydroxy propionyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "3-hydroxypropionyl-CoA synthetase activity", "definition": "Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate. [GOC:jl, PMID:11821399]"}
{"concept_id": "C2613300", "aliases": ["acetyl-coenzyme A synthetase/GroES-like domain"], "types": ["T044"], "canonical_name": "acetyl-coenzyme A synthetase/GroES-like domain"}
{"concept_id": "C2613301", "aliases": ["AMP-dependent synthetase and ligase"], "types": ["T044"], "canonical_name": "AMP-dependent synthetase and ligase"}
{"concept_id": "C2613302", "aliases": ["AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase", "AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase"], "types": ["T044"], "canonical_name": "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase"}
{"concept_id": "C2613303", "aliases": ["enoyl-CoA hydratase/isomerase"], "types": ["T044"], "canonical_name": "enoyl-CoA hydratase/isomerase"}
{"concept_id": "C2613304", "aliases": ["3-hydroxy propionyl-CoA dehydratase activity"], "types": ["T044"], "canonical_name": "3-hydroxypropionyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O. [GOC:jl, PMID:11821399]"}
{"concept_id": "C2613305", "aliases": ["acrylyl-CoA reductase (NADPH) activity", "acryloyl-CoA reductase (NADPH) activity"], "types": ["T044"], "canonical_name": "acryloyl-CoA reductase (NADP+) activity", "definition": "Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+. [GOC:jl, PMID:11821399, RHEA:26454]"}
{"concept_id": "C2613306", "aliases": ["acetyl-coenzyme A synthetase"], "types": ["T044"], "canonical_name": "acetyl-coenzyme A synthetase"}
{"concept_id": "C2613307", "aliases": ["acrylyl-CoA reductase (NADH)", "acryloyl-coenzyme A reductase activity", "propionyl-CoA dehydrogenase"], "types": ["T044"], "canonical_name": "acryloyl-CoA reductase activity", "definition": "Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein. [GOC:jl, PMID:12603323]"}
{"concept_id": "C2613308", "aliases": [], "types": ["T044"], "canonical_name": "L-erythro-3-methylmalyl-CoA lyase activity", "definition": "Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA. [GOC:jl]"}
{"concept_id": "C2613309", "aliases": [], "types": ["T044"], "canonical_name": "HpcH/HpaI aldolase"}
{"concept_id": "C2613310", "aliases": [], "types": ["T044"], "canonical_name": "L-erythro-3-methylmalyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O. [GOC:jl]"}
{"concept_id": "C2613311", "aliases": ["succinyl-CoA:(R)-citramalate CoA transferase activity", "succinyl-CoA:R-citramalate CoA transferase"], "types": ["T044"], "canonical_name": "succinyl-CoA:(R)-citramalate CoA-transferase activity", "definition": "Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA. [GOC:jl, PMID:17259315]"}
{"concept_id": "C2613312", "aliases": [], "types": ["T044"], "canonical_name": "L-carnitine dehydratase/bile acid-inducible protein F"}
{"concept_id": "C2613314", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host adenylate cyclase-mediated signal transduction", "definition": "Any process in which the symbiont modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2613315", "aliases": ["positive regulation by symbiont of host adenylate cyclase-mediated signal transduction"], "types": ["T040"], "canonical_name": "induction by symbiont of host adenylate cyclase-mediated signal transduction", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2613316", "aliases": ["negative regulation by symbiont of host adenylate cyclase-mediated signal transduction"], "types": ["T040"], "canonical_name": "suppression by symbiont of host adenylate cyclase-mediated signal transduction", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2613317", "aliases": [], "types": ["T044"], "canonical_name": "histone H3 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group. [GOC:jl]"}
{"concept_id": "C2613318", "aliases": [], "types": ["T044"], "canonical_name": "histone H4 acetylation", "definition": "The modification of histone H4 by the addition of an acetyl group. [GOC:jl]"}
{"concept_id": "C2613319", "aliases": [], "types": ["T044"], "canonical_name": "histone H2A acetylation", "definition": "The modification of histone H2A by the addition of an acetyl group. [GOC:jl]"}
{"concept_id": "C2613320", "aliases": [], "types": ["T044"], "canonical_name": "histone H2B acetylation", "definition": "The modification of histone H2B by the addition of an acetyl group. [GOC:jl]"}
{"concept_id": "C2613321", "aliases": ["histone H3 acetylation at K9", "histone H3K9 acetylation"], "types": ["T044"], "canonical_name": "histone H3-K9 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone. [GOC:jl]"}
{"concept_id": "C2613322", "aliases": ["histone H3K18 acetylation", "histone H3 acetylation at K18"], "types": ["T044"], "canonical_name": "histone H3-K18 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone. [GOC:jl]"}
{"concept_id": "C2613323", "aliases": ["histone H3K23 acetylation", "histone H3 acetylation at K23"], "types": ["T044"], "canonical_name": "histone H3-K23 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone. [GOC:jl]"}
{"concept_id": "C2613324", "aliases": ["histone H3 acetylation at K4", "histone H3K4 acetylation"], "types": ["T044"], "canonical_name": "histone H3-K4 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone. [GOC:jl]"}
{"concept_id": "C2613325", "aliases": ["histone H3K27 acetylation", "histone H3 acetylation at K27"], "types": ["T044"], "canonical_name": "histone H3-K27 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone. [GOC:jl]"}
{"concept_id": "C2613326", "aliases": ["histone H3 acetylation at K36", "histone H3K36 acetylation"], "types": ["T044"], "canonical_name": "histone H3-K36 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone. [GOC:jl]"}
{"concept_id": "C2613327", "aliases": ["histone H3 acetylation at K79", "histone H3K79 acetylation"], "types": ["T044"], "canonical_name": "histone H3-K79 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone. [GOC:jl]"}
{"concept_id": "C2613328", "aliases": ["histone H2A acetylation at K5"], "types": ["T044"], "canonical_name": "histone H2A-K5 acetylation", "definition": "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone. [GOC:jl]"}
{"concept_id": "C2613329", "aliases": ["histone H2A acetylation at K9"], "types": ["T044"], "canonical_name": "histone H2A-K9 acetylation", "definition": "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone. [GOC:jl]"}
{"concept_id": "C2613330", "aliases": ["histone H2B acetylation at K5"], "types": ["T044"], "canonical_name": "histone H2B-K5 acetylation", "definition": "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone. [GOC:jl]"}
{"concept_id": "C2613331", "aliases": ["histone H2B acetylation at K12"], "types": ["T044"], "canonical_name": "histone H2B-K12 acetylation", "definition": "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone. [GOC:jl]"}
{"concept_id": "C2613332", "aliases": ["histone H4 acetylation at K5"], "types": ["T044"], "canonical_name": "histone H4-K5 acetylation", "definition": "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone. [GOC:jl]"}
{"concept_id": "C2613333", "aliases": ["histone H4 acetylation at K8"], "types": ["T044"], "canonical_name": "histone H4-K8 acetylation", "definition": "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone. [GOC:jl]"}
{"concept_id": "C2613334", "aliases": ["histone H4 acetylation at K12"], "types": ["T044"], "canonical_name": "histone H4-K12 acetylation", "definition": "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone. [GOC:jl]"}
{"concept_id": "C2613335", "aliases": ["histone H4 acetylation at K16"], "types": ["T044"], "canonical_name": "histone H4-K16 acetylation", "definition": "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone. [GOC:jl]"}
{"concept_id": "C2613336", "aliases": ["histone H4 R3 methylation", "histone H4R3me", "histone H4 methylation at R3"], "types": ["T044"], "canonical_name": "histone H4-R3 methylation", "definition": "The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone. [GOC:mah]"}
{"concept_id": "C2613338", "aliases": ["histone H3 phosphorylation at S10", "histone H3S10 phosphorylation"], "types": ["T044"], "canonical_name": "histone H3-S10 phosphorylation", "definition": "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone. [GOC:jl]"}
{"concept_id": "C2613339", "aliases": ["histone H3 phosphorylation at S28", "histone H3S28 phosphorylation"], "types": ["T044"], "canonical_name": "histone H3-S28 phosphorylation", "definition": "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone. [GOC:jl]"}
{"concept_id": "C2613340", "aliases": ["histone H4 phosphorylation at S1", "histone H4S1 phosphorylation"], "types": ["T044"], "canonical_name": "histone H4-S1 phosphorylation", "definition": "The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone. [GOC:jl]"}
{"concept_id": "C2613341", "aliases": ["histone H2A phosphorylation at S1", "histone H2AS1 phosphorylation"], "types": ["T044"], "canonical_name": "histone H2A-S1 phosphorylation", "definition": "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone. [GOC:jl]"}
{"concept_id": "C2613342", "aliases": ["histone H2B phosphorylation at S14", "histone H2BS14 phosphorylation"], "types": ["T044"], "canonical_name": "histone H2B-S14 phosphorylation", "definition": "The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone. [GOC:jl]"}
{"concept_id": "C2613343", "aliases": ["histone lysine N-acetyltransferase activity (H3-K9 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H3-K9 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9). [EC:2.3.1.48]"}
{"concept_id": "C2613344", "aliases": ["histone lysine N-acetyltransferase activity (H3-K18 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H3-K18 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18). [EC:2.3.1.48]"}
{"concept_id": "C2613345", "aliases": ["histone lysine N-acetyltransferase activity (H3-K23 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H3-K23 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23). [EC:2.3.1.48]"}
{"concept_id": "C2613346", "aliases": ["histone lysine N-acetyltransferase activity (H4-K5 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H4-K5 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5). [EC:2.3.1.48]"}
{"concept_id": "C2613347", "aliases": ["histone lysine N-acetyltransferase activity (H4-K8 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H4-K8 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8). [EC:2.3.1.48]"}
{"concept_id": "C2613348", "aliases": ["histone lysine N-acetyltransferase activity (H4-K12 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H4-K12 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). [EC:2.3.1.48]"}
{"concept_id": "C2613349", "aliases": ["H2A histone lysine N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "H2A histone acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine. [EC:2.3.1.48]"}
{"concept_id": "C2613350", "aliases": ["histone lysine N-acetyltransferase activity (H2A-K5 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H2A-K5 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5). [EC:2.3.1.48]"}
{"concept_id": "C2613351", "aliases": ["histone lysine N-acetyltransferase activity (H2A-K9 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H2A-K9 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9). [EC:2.3.1.48]"}
{"concept_id": "C2613352", "aliases": ["H2B histone lysine N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "H2B histone acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine. [EC:2.3.1.48]"}
{"concept_id": "C2613353", "aliases": ["histone lysine N-acetyltransferase activity (H2B-K5 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H2B-K5 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5). [EC:2.3.1.48]"}
{"concept_id": "C2613354", "aliases": ["histone lysine N-acetyltransferase activity (H2B-K12 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H2B-K12 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12). [EC:2.3.1.48]"}
{"concept_id": "C2613355", "aliases": ["histone lysine N-acetyltransferase activity (H3-K4 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H3-K4 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4). [EC:2.3.1.48]"}
{"concept_id": "C2613356", "aliases": ["histone lysine N-acetyltransferase activity (H3-K27 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H3-K27 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27). [EC:2.3.1.48]"}
{"concept_id": "C2613357", "aliases": ["histone lysine N-acetyltransferase activity (H3-K36 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H3-K36 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36). [EC:2.3.1.48]"}
{"concept_id": "C2613358", "aliases": ["histone lysine N-acetyltransferase activity (H3-K72 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H3-K72 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72). [EC:2.3.1.48]"}
{"concept_id": "C2613359", "aliases": ["histone-arginine N-methyltransferase activity (H4-R3 specific)", "histone methylase activity (H4-R3 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H4-R3 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4. [GOC:mah, PMID:17898714]"}
{"concept_id": "C2613361", "aliases": ["histone serine kinase activity (H3-S28 specific)", "histone-serine kinase activity (H3-S28 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H3-S28 specific)", "definition": "Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3. [GOC:jl]"}
{"concept_id": "C2613362", "aliases": ["histone-serine kinase activity (H4-S1 specific)", "histone serine kinase activity (H4-S1 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H4-S1 specific)", "definition": "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H4. [GOC:jl]"}
{"concept_id": "C2613363", "aliases": ["histone-serine kinase activity (H2A-S1 specific)", "histone serine kinase activity (H2A-S1 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H2A-S1 specific)", "definition": "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A. [GOC:jl]"}
{"concept_id": "C2613364", "aliases": ["histone-serine kinase activity (H2B-S14 specific)", "histone serine kinase activity (H2B-S14 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H2B-S14 specific)", "definition": "Catalysis of the transfer of a phosphate group to the serine-14 or an equivalent residue of the N-terminal tail of histone H2B. [GOC:jl]"}
{"concept_id": "C2613365", "aliases": [], "types": ["T045"], "canonical_name": "DNA hypermethylation", "definition": "An increase in the epigenetic methylation of cytosine and adenosine residues in DNA. [GOC:jl, http://en.wiktionary.org/]"}
{"concept_id": "C2613366", "aliases": ["DNA hypermethylation of CpG island"], "types": ["T045"], "canonical_name": "hypermethylation of CpG island", "definition": "An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. [GOC:jl, Wikipedia:Cpg_island]"}
{"concept_id": "C2613367", "aliases": [], "types": ["T045"], "definition": "An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA. [GOC:jl, http://en.wiktionary.org/hypomethylation]", "canonical_name": "DNA hypomethylation"}
{"concept_id": "C2613368", "aliases": ["DNA hypomethylation of CpG island"], "types": ["T045"], "canonical_name": "hypomethylation of CpG island", "definition": "An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. [GOC:jl, Wikipedia:Cpg_island]"}
{"concept_id": "C2613370", "aliases": ["modulation by symbiont of IAA levels in host"], "types": ["T040"], "canonical_name": "modulation by symbiont of indole acetic acid levels in host", "definition": "The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C2613371", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of auxin levels in host"}
{"concept_id": "C2613381", "aliases": ["glucan metabolism"], "types": ["T044"], "canonical_name": "glucan metabolic process", "definition": "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. [GOC:jl]"}
{"concept_id": "C2613393", "aliases": ["transport of peptides or proteins into host cell cytoplasm", "translocation of symbiont peptides or proteins into host cell cytoplasm"], "types": ["T043"], "canonical_name": "translocation of peptides or proteins into host cell cytoplasm", "definition": "The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm. [MITRE:tk]"}
{"concept_id": "C2613394", "aliases": [], "types": ["T040"], "canonical_name": "rounding by symbiont of host cells"}
{"concept_id": "C2613395", "aliases": ["modulation by symbiont of host system process"], "types": ["T040"], "canonical_name": "modulation by symbiont of host system process", "definition": "The process in which a symbiont organism effects a change in an anatomical system process of its host organism. [GOC:pg]"}
{"concept_id": "C2613396", "aliases": ["regulation by symbiont of host digestive system process"], "types": ["T040"], "canonical_name": "modulation by symbiont of host digestive system process", "definition": "The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [MITRE:tk]"}
{"concept_id": "C2613397", "aliases": [], "types": ["T038"], "canonical_name": "regulation of system process", "definition": "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. [GOC:jl]"}
{"concept_id": "C2613398", "aliases": [], "types": ["T038"], "canonical_name": "regulation of digestive system process", "definition": "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:jl]"}
{"concept_id": "C2613399", "aliases": ["regulation by symbiont of host endocrine process"], "types": ["T040"], "canonical_name": "modulation by symbiont of host endocrine process", "definition": "The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism. [MITRE:tk]"}
{"concept_id": "C2613400", "aliases": ["regulation of endocrine system process"], "types": ["T038"], "canonical_name": "regulation of endocrine process", "definition": "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. [GOC:jl]"}
{"concept_id": "C2613402", "aliases": [], "types": ["T038"], "canonical_name": "regulation of excretion", "definition": "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. [GOC:jl]"}
{"concept_id": "C2613403", "aliases": ["regulation by symbiont of host neurological system process", "modulation by symbiont of host neurological system process"], "types": ["T040"], "canonical_name": "modulation by symbiont of host nervous system process", "definition": "The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. [MITRE:tk]"}
{"concept_id": "C2613404", "aliases": ["regulation by symbiont of host respiratory system process"], "types": ["T040"], "canonical_name": "modulation by symbiont of host respiratory system process", "definition": "The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. [MITRE:tk]"}
{"concept_id": "C2613405", "aliases": [], "types": ["T038"], "canonical_name": "regulation of respiratory system process", "definition": "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. [GOC:jl]"}
{"concept_id": "C2613406", "aliases": ["modification by symbiont of host nucleus", "modification of host cell nucleus by symbiont", "modification of host nucleus by symbiont"], "types": ["T040"], "canonical_name": "modification by symbiont of host cell nucleus", "definition": "The process in which a symbiont organism effects a change in the structure or function of its host cell nucleus. [MITRE:tk]"}
{"concept_id": "C2613407", "aliases": ["modification of host intercellular junctions by symbiont"], "types": ["T040"], "canonical_name": "modification by symbiont of host intercellular junctions", "definition": "The process in which a symbiont organism effects a change in the structure or function of its host intercellular junction, a specialized region of connection between two cells. [MITRE:tk]"}
{"concept_id": "C2613408", "aliases": ["regulation by symbiont of host cellular process", "regulation of host cellular process by symbiont", "modulation of host cellular process by symbiont"], "types": ["T040"], "canonical_name": "modulation by symbiont of host cellular process", "definition": "Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. [MITRE:tk]"}
{"concept_id": "C2613409", "aliases": ["modification of host anion transport by symbiont"], "types": ["T040"], "canonical_name": "modulation by symbiont of host anion transport", "definition": "The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism. [MITRE:tk]"}
{"concept_id": "C2613410", "aliases": [], "types": ["T043"], "canonical_name": "regulation of anion transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C2613411", "aliases": ["modification by symbiont of host cell cycle", "regulation by symbiont of host cell cycle", "modulation of host cell cycle by symbiont"], "types": ["T040"], "canonical_name": "modulation by symbiont of host cell cycle", "definition": "The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery. [MITRE:tk]"}
{"concept_id": "C2613412", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of host cell cycle", "definition": "The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery. [MITRE:tk]"}
{"concept_id": "C2613413", "aliases": ["modification by symbiont of host translation", "regulation by symbiont of host translation", "modulation of host translation by symbiont"], "types": ["T040"], "canonical_name": "modulation by symbiont of host translation", "definition": "The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism. [MITRE:tk]"}
{"concept_id": "C2613414", "aliases": ["negative regulation of host translation by symbiont"], "types": ["T040"], "canonical_name": "negative regulation by symbiont of host translation", "definition": "The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism. [MITRE:tk]"}
{"concept_id": "C2613415", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host vacuole biogenesis"}
{"concept_id": "C2613416", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host vacuole biogenesis"}
{"concept_id": "C2613417", "aliases": ["modulation of host receptor-mediated endocytosis by symbiont", "regulation by symbiont of host receptor-mediated endocytosis"], "types": ["T040"], "canonical_name": "modulation by symbiont of host receptor-mediated endocytosis", "definition": "The process in which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism. [MITRE:tk]"}
{"concept_id": "C2613418", "aliases": ["positive regulation of host receptor-mediated endocytosis by symbiont"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host receptor-mediated endocytosis", "definition": "Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism. [MITRE:tk]"}
{"concept_id": "C2613419", "aliases": ["regulation by symbiont of host neurotransmitter secretion", "modulation of host neurotransmitter secretion by symbiont", "modification by symbiont of host neurotransmitter secretion"], "types": ["T040"], "canonical_name": "modulation by symbiont of host neurotransmitter secretion", "definition": "Any process in which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell in its host organism. [MITRE:tk]"}
{"concept_id": "C2613420", "aliases": ["modulation of host cGMP-mediated signal transduction by symbiont", "regulation by symbiont of host cGMP-mediated signal transduction", "modulation by symbiont of host cGMP-mediated signalling", "modulation by symbiont of host cGMP-mediated signaling", "modulation by symbiont of host cGMP-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "modulation by symbiont of host cGMP-mediated signal transduction", "definition": "Any process in which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. [MITRE:tk]"}
{"concept_id": "C2613421", "aliases": ["modulation of host nitric oxide-mediated signal transduction by symbiont", "modulation of host nitric oxide-mediated signalling by symbiont", "modulation by symbiont of host nitric oxide mediated signal transduction", "regulation by symbiont of host nitric oxide-mediated signal transduction", "modulation of host nitric oxide-mediated signaling by symbiont"], "types": ["T040"], "canonical_name": "modulation by symbiont of host nitric oxide-mediated signal transduction", "definition": "Any process in which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. [MITRE:tk]"}
{"concept_id": "C2613422", "aliases": ["regulation by symbiont of host small GTPase mediated signal transduction", "modulation of host small GTPase mediated signal transduction by symbiont"], "types": ["T040"], "canonical_name": "modulation by symbiont of host small GTPase mediated signal transduction", "definition": "Any process in which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism. [MITRE:tk]"}
{"concept_id": "C2613423", "aliases": ["regulation by symbiont of host Rho protein signal transduction", "modulation of host Rho protein signalling by symbiont", "modulation by symbiont of host Rho protein mediated signal transduction", "modulation of host Rho protein signaling by symbiont", "modulation of host Rho protein signal transduction by symbiont", "modulation by symbiont of host Rho protein-mediated signal transduction"], "types": ["T040"], "canonical_name": "modulation by symbiont of host Rho protein signal transduction", "definition": "Any process in which a symbiont organism modulates the frequency, rate or extent of Rho protein signal transduction in its host organism. [MITRE:tk]"}
{"concept_id": "C2613424", "aliases": ["host cell membrane pore complex location", "pore complex in host cell membrane", "pore complex location in host cell membrane"], "types": ["T026"], "canonical_name": "host cell membrane pore complex", "definition": "Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins. [MITRE:tk]"}
{"concept_id": "C2613426", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular component biogenesis", "definition": "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. [GOC:jl]"}
{"concept_id": "C2613427", "aliases": ["regulation of vacuole biogenesis", "regulation of vacuole organisation"], "types": ["T043"], "canonical_name": "regulation of vacuole organization", "definition": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. [GOC:jl, GOC:mah]"}
{"concept_id": "C2613428", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cellular component biogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. [GOC:jl]"}
{"concept_id": "C2613429", "aliases": ["positive regulation of vacuole organisation", "positive regulation of vacuole biogenesis"], "types": ["T043"], "canonical_name": "positive regulation of vacuole organization", "definition": "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. [GOC:jl, GOC:mah]"}
{"concept_id": "C2613431", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of protein location in Golgi apparatus"}
{"concept_id": "C2613432", "aliases": [], "types": ["T043"], "canonical_name": "meiotic telomere clustering", "definition": "The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis. [GOC:vw, PMID:10690419]"}
{"concept_id": "C2613433", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein location", "definition": "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away. [GOC:bf]"}
{"concept_id": "C2613434", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of epithelial cell apical/basal polarity", "definition": "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. [GOC:bf, GOC:mah]"}
{"concept_id": "C2613435", "aliases": [], "types": ["T043"], "canonical_name": "establishment of epithelial cell apical/basal polarity", "definition": "The specification and formation of the apicobasal polarity of an epithelial cell. [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]"}
{"concept_id": "C2613436", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of epithelial cell apical/basal polarity", "definition": "The maintenance of the apicobasal polarity of an epithelial cell. [GOC:bf]"}
{"concept_id": "C2613437", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell junction biogenesis"}
{"concept_id": "C2613438", "aliases": ["MTOC attachment site", "microtubule organising centre attachment site", "microtubule organizing center attachment site"], "types": ["T026"], "definition": "A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope. [GOC:mah, PMID:18692466]", "canonical_name": "MAS"}
{"concept_id": "C2613442", "aliases": ["hydrogen ion transporting ATP synthase activity, rotational mechanism", "H+-transporting ATP synthase activity", "hydrogen ion transporting two-sector ATPase activity", "hydrogen ion translocating F-type ATPase activity"], "types": ["T044"], "definition": "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out). [RHEA:57720]", "canonical_name": "proton-transporting ATP synthase activity, rotational mechanism"}
{"concept_id": "C2673153", "aliases": ["holo-citrate lyase synthase activity", "2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity", "CitX", "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase. [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN]", "canonical_name": "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity"}
{"concept_id": "C2673159", "aliases": [], "types": ["T044"], "canonical_name": "heparin 2-sulfotransferase activity"}
{"concept_id": "C2673160", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of striated muscle cell apoptosis"}
{"concept_id": "C2673177", "aliases": [], "types": ["T044"], "canonical_name": "proteinase inhibitor"}
{"concept_id": "C2673180", "aliases": ["photosynthetic membrane"], "types": ["T026"], "canonical_name": "photosynthetic membrane", "definition": "A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place. [GOC:ds, GOC:mah]"}
{"concept_id": "C2678064", "aliases": [], "types": ["T026"], "definition": "A glass-like, pale intracellular inclusion. [NIF_Subcellular:nlx_subcell_20090104]", "canonical_name": "hyaline inclusion"}
{"concept_id": "C2678506", "aliases": [], "types": ["T043"], "definition": "The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet. [GOC:dph, PMID:16962574, PMID:18343170]", "canonical_name": "delamination"}
{"concept_id": "C2678510", "aliases": ["non-sensory hair"], "types": ["T026"], "definition": "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located. [PMID:11526084]", "canonical_name": "cell hair"}
{"concept_id": "C2700623", "aliases": ["NAD(P)H sulfur oxidoreductase activity", "NAD(P)H:sulfur oxidoreductase activity", "coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity", "NSR", "NADPH:sulfur oxidoreductase activity", "NADPH:sulphur oxidoreductase activity", "NAD(P)H elemental sulfur oxidoreductase activity", "NAD(P)H sulphur oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+. [GOC:jl, PMID:17449625]", "canonical_name": "CoA-dependent NAD(P)H sulfur oxidoreductase activity"}
{"concept_id": "C2700624", "aliases": ["activated T lymphocyte autonomous cell death", "activated T-cell autonomous cell death", "activated T cell autonomous cell death", "activated T-lymphocyte autonomous cell death"], "types": ["T043"], "definition": "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "canonical_name": "ACAD"}
{"concept_id": "C2717754", "aliases": [], "types": ["T026"], "definition": "Membrane-bound prokaryotic organelles of magnetotactic bacteria that contain chains of MAGNETITE crystals which orient the bacteria to geomagnetic fields.", "canonical_name": "magnetosome"}
{"concept_id": "C2717976", "aliases": [], "types": ["T070"], "canonical_name": "virus budding"}
{"concept_id": "C2746015", "aliases": ["protein serine-threonine kinase activity", "serine(threonine) protein kinase activity", "serine/threonine protein kinase activity"], "types": ["T044"], "definition": "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, PMID:2956925]", "canonical_name": "protein serine/threonine kinase activity"}
{"concept_id": "C2746082", "aliases": [], "types": ["T033"], "canonical_name": "ventricular depolarization"}
{"concept_id": "C2752169", "aliases": ["contractile ring localization involved in cell cycle cytokinesis", "contractile ring localisation involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "actomyosin contractile ring localization", "definition": "The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle. [GOC:mah]"}
{"concept_id": "C2752170", "aliases": ["establishment of contractile ring localization involved in cell cycle cytokinesis", "establishment of contractile ring localization involved in cytokinesis during cell cycle", "cytokinesis site selection by contractile ring positioning", "establishment of contractile ring localisation involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "establishment of actomyosin contractile ring localization", "definition": "The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis. [GOC:mah]"}
{"concept_id": "C2752171", "aliases": ["maintenance of contractile ring localisation involved in cell cycle cytokinesis", "maintenance of contractile ring localization involved in cell cycle cytokinesis", "maintenance of contractile ring localization involved in cytokinesis during cell cycle"], "types": ["T043"], "canonical_name": "maintenance of actomyosin contractile ring localization", "definition": "Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere. [GOC:mah]"}
{"concept_id": "C2752172", "aliases": [], "types": ["T043"], "canonical_name": "cell wall macromolecule catabolic process during cytogamy"}
{"concept_id": "C2752173", "aliases": ["regulation of actin cable assembly"], "types": ["T043"], "canonical_name": "regulation of actin filament bundle assembly", "definition": "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. [GOC:mah]"}
{"concept_id": "C2752174", "aliases": [], "types": ["T040"], "canonical_name": "response to endotoxin"}
{"concept_id": "C2752176", "aliases": ["ER-dependent peroxisome organisation", "endoplasmic reticulum-dependent peroxisome organization"], "types": ["T043"], "canonical_name": "ER-dependent peroxisome organization", "definition": "A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum. [GOC:mah, PMID:16717127, PMID:17646399]"}
{"concept_id": "C2752177", "aliases": ["neuron cell body membrane", "neuronal cell soma membrane"], "types": ["T026"], "canonical_name": "neuronal cell body membrane", "definition": "The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. [GOC:jl]"}
{"concept_id": "C2752178", "aliases": [], "types": ["T044"], "canonical_name": "hydroperoxide reductase activity", "definition": "Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol. [GOC:mlg, PMID:12540833]"}
{"concept_id": "C2752179", "aliases": ["ATPase-coupled oligogalacturonide transmembrane transporter activity", "oligogalacturonide-transporting ATPase activity", "ATP-dependent oligogalacturonide transmembrane transporter activity", "oligogalacturonide transporting ATPase activity"], "types": ["T044"], "canonical_name": "ABC-type oligogalacturonide transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in). [GOC:mlg, PMID:11555291, PMID:17451747]"}
{"concept_id": "C2752181", "aliases": ["phenylalanine tRNA"], "types": ["T045"], "canonical_name": "phenylalanine tRNA"}
{"concept_id": "C2752182", "aliases": ["leucine tRNA"], "types": ["T045"], "canonical_name": "leucine tRNA"}
{"concept_id": "C2752183", "aliases": [], "types": ["T045"], "canonical_name": "serine tRNA"}
{"concept_id": "C2752184", "aliases": ["tyrosine tRNA"], "types": ["T045"], "canonical_name": "tyrosine tRNA"}
{"concept_id": "C2752185", "aliases": ["cysteine tRNA"], "types": ["T045"], "canonical_name": "cysteine tRNA"}
{"concept_id": "C2752186", "aliases": [], "types": ["T045"], "canonical_name": "tryptophan tRNA"}
{"concept_id": "C2752187", "aliases": [], "types": ["T045"], "canonical_name": "proline tRNA"}
{"concept_id": "C2752188", "aliases": [], "types": ["T045"], "canonical_name": "histidine tRNA"}
{"concept_id": "C2752189", "aliases": [], "types": ["T045"], "canonical_name": "glutamine tRNA"}
{"concept_id": "C2752190", "aliases": ["arginine tRNA"], "types": ["T045"], "canonical_name": "arginine tRNA"}
{"concept_id": "C2752191", "aliases": ["isoleucine tRNA"], "types": ["T045"], "canonical_name": "isoleucine tRNA"}
{"concept_id": "C2752192", "aliases": ["methionine tRNA"], "types": ["T045"], "canonical_name": "initiator methionine tRNA"}
{"concept_id": "C2752193", "aliases": [], "types": ["T045"], "canonical_name": "threonine tRNA"}
{"concept_id": "C2752194", "aliases": ["asparagine tRNA"], "types": ["T045"], "canonical_name": "asparagine tRNA"}
{"concept_id": "C2752195", "aliases": [], "types": ["T045"], "canonical_name": "lysine tRNA"}
{"concept_id": "C2752196", "aliases": ["valine tRNA"], "types": ["T045"], "canonical_name": "valine tRNA"}
{"concept_id": "C2752197", "aliases": [], "types": ["T045"], "canonical_name": "alanine tRNA"}
{"concept_id": "C2752198", "aliases": ["aspartic acid tRNA"], "types": ["T045"], "canonical_name": "aspartic acid tRNA"}
{"concept_id": "C2752199", "aliases": [], "types": ["T045"], "canonical_name": "glycine tRNA"}
{"concept_id": "C2752200", "aliases": [], "types": ["T044"], "canonical_name": "dopamine neurotransmitter receptor activity, coupled via Gs", "definition": "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260]"}
{"concept_id": "C2752201", "aliases": [], "types": ["T044"], "canonical_name": "dopamine neurotransmitter receptor activity, coupled via Gi/Go", "definition": "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2254, IUPHAR_RECEPTOR:2256, IUPHAR_RECEPTOR:2258]"}
{"concept_id": "C2752202", "aliases": [], "types": ["T042"], "canonical_name": "endoblast formation"}
{"concept_id": "C2752203", "aliases": [], "types": ["T042"], "canonical_name": "optic placode development"}
{"concept_id": "C2752205", "aliases": [], "types": ["T045"], "canonical_name": "centromere specific nucleosome exchange"}
{"concept_id": "C2752206", "aliases": [], "types": ["T044"], "canonical_name": "D,D-heptose 1,7-bisphosphate phosphatase activity", "definition": "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate. [MetaCyc:RXN0-4361, PMID:11279237]"}
{"concept_id": "C2752208", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxylaminobenzoate reductase activity", "definition": "Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O. [MetaCyc:RXN-8848]"}
{"concept_id": "C2752209", "aliases": [], "types": ["T043"], "canonical_name": "adaptive response to oxidative stress"}
{"concept_id": "C2752210", "aliases": ["anterior/posterior pattern specification involved in pronephric kidney development"], "types": ["T043"], "canonical_name": "anterior/posterior pattern specification involved in pronephros development", "definition": "The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate. [GOC:mah]"}
{"concept_id": "C2752211", "aliases": [], "types": ["T044"], "canonical_name": "aminohydroquinone monooxygenase activity", "definition": "Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3. [UM-BBD_reactionID:r1497]"}
{"concept_id": "C2752212", "aliases": [], "types": ["T043"], "canonical_name": "male pronucleus assembly", "definition": "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division. [GOC:bf, PMID:11735001]"}
{"concept_id": "C2752214", "aliases": ["tube lumen formation"], "types": ["T042"], "canonical_name": "tube formation", "definition": "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. [GOC:bf]"}
{"concept_id": "C2752215", "aliases": [], "types": ["T026"], "canonical_name": "female germline ring canal outer rim", "definition": "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues. [PMID:12435357, PMID:7925006]"}
{"concept_id": "C2752216", "aliases": [], "types": ["T026"], "canonical_name": "nurse cell ring canal outer rim"}
{"concept_id": "C2752217", "aliases": [], "types": ["T026"], "canonical_name": "ovarian ring canal outer rim"}
{"concept_id": "C2752218", "aliases": [], "types": ["T026"], "canonical_name": "female germline ring canal inner rim", "definition": "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins. [PMID:10556087, PMID:7925006, PMID:9093858]"}
{"concept_id": "C2752219", "aliases": [], "types": ["T026"], "canonical_name": "nurse cell ring canal inner rim"}
{"concept_id": "C2752220", "aliases": [], "types": ["T026"], "canonical_name": "ovarian ring canal inner rim"}
{"concept_id": "C2752224", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hemocyte proliferation"}
{"concept_id": "C2752225", "aliases": [], "types": ["T043"], "canonical_name": "activation of hemocyte proliferation"}
{"concept_id": "C2752226", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of hemocyte proliferation"}
{"concept_id": "C2752229", "aliases": ["metabotropic glutamate receptor binding", "G-protein coupled glutamate receptor binding"], "types": ["T044"], "canonical_name": "G protein-coupled glutamate receptor binding", "definition": "Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor). [GOC:bf, ISBN:0198506732, PMID:9069287]"}
{"concept_id": "C2752230", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of translation involved in gene silencing by miRNA"}
{"concept_id": "C2752231", "aliases": [], "types": ["T043"], "canonical_name": "trichome organisation"}
{"concept_id": "C2752232", "aliases": [], "types": ["T043"], "canonical_name": "trichome organization and biogenesis"}
{"concept_id": "C2752233", "aliases": [], "types": ["T038"], "canonical_name": "mesenchymal cell migration involved in limb bud formation", "definition": "The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud. [GOC:dgh]"}
{"concept_id": "C2752234", "aliases": [], "types": ["T026"], "canonical_name": "male germline ring canal", "definition": "An intercellular bridge that connects the germline cells of a male cyst. [PMID:9635420]"}
{"concept_id": "C2752235", "aliases": [], "types": ["T026"], "canonical_name": "spermatocyte ring canal"}
{"concept_id": "C2752236", "aliases": [], "types": ["T026"], "canonical_name": "testicular ring canal"}
{"concept_id": "C2752237", "aliases": [], "types": ["T026"], "canonical_name": "female germline ring canal", "definition": "An intercellular bridge that connects the germline cells of a female cyst. [PMID:9635420]"}
{"concept_id": "C2752238", "aliases": [], "types": ["T026"], "canonical_name": "nurse cell ring canal"}
{"concept_id": "C2752239", "aliases": [], "types": ["T026"], "canonical_name": "ovarian ring canal"}
{"concept_id": "C2752240", "aliases": ["TLR binding"], "types": ["T044"], "canonical_name": "Toll-like receptor binding", "definition": "Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. [PMID:19076341]"}
{"concept_id": "C2752244", "aliases": ["Salvador-Warts-Hippo signaling pathway"], "types": ["T077"], "canonical_name": "SWH pathway"}
{"concept_id": "C2752245", "aliases": ["regulation of hippo signaling pathway", "regulation of hippo signalling cascade", "regulation of hippo signaling cascade"], "types": ["T044"], "canonical_name": "regulation of hippo signaling", "definition": "Any process that modulates the frequency, rate or extent of hippo signaling. [GOC:bf]"}
{"concept_id": "C2752246", "aliases": ["negative regulation of hippo signaling cascade", "negative regulation of hippo signalling cascade", "negative regulation of hippo signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of hippo signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling. [GOC:bf]"}
{"concept_id": "C2752247", "aliases": ["positive regulation of hippo signalling cascade", "positive regulation of hippo signaling pathway", "positive regulation of hippo signaling cascade"], "types": ["T044"], "canonical_name": "positive regulation of hippo signaling", "definition": "Any process that activates or increases the frequency, rate or extent of hippo signaling. [GOC:bf]"}
{"concept_id": "C2752248", "aliases": [], "types": ["T044"], "canonical_name": "Notch receptor processing, ligand-dependent", "definition": "The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). [GOC:bf, PMID:12651094]"}
{"concept_id": "C2752249", "aliases": [], "types": ["T044"], "canonical_name": "Notch S2 cleavage"}
{"concept_id": "C2752250", "aliases": [], "types": ["T044"], "canonical_name": "Notch S3 cleavage"}
{"concept_id": "C2752251", "aliases": [], "types": ["T044"], "canonical_name": "Notch receptor processing, ligand-independent", "definition": "The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface. [GOC:bf, PMID:12651094]"}
{"concept_id": "C2752252", "aliases": [], "types": ["T044"], "canonical_name": "Notch S1 cleavage"}
{"concept_id": "C2752253", "aliases": [], "types": ["T040"], "canonical_name": "peptidyl-tyrosine dephosphorylation", "definition": "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf]"}
{"concept_id": "C2752254", "aliases": ["long-chain fatty acyl CoA metabolic process", "long-chain fatty acyl-CoA metabolism"], "types": ["T044"], "canonical_name": "long-chain fatty-acyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. [ISBN:0198506732]"}
{"concept_id": "C2752255", "aliases": ["fatty acyl CoA metabolic process", "fatty-acyl-CoA metabolism"], "types": ["T044"], "canonical_name": "fatty-acyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. [ISBN:0198506732]"}
{"concept_id": "C2752256", "aliases": ["long-chain fatty acyl CoA biosynthetic process", "long-chain fatty-acyl-CoA formation", "long-chain fatty-acyl-CoA synthesis", "long-chain fatty-acyl-CoA anabolism", "long-chain fatty-acyl-CoA biosynthesis"], "types": ["T044"], "canonical_name": "long-chain fatty-acyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. [ISBN:0198506732]"}
{"concept_id": "C2752257", "aliases": ["SPOTS complex location", "serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex location", "serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex"], "types": ["T026"], "canonical_name": "SPOTS complex", "definition": "A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis. [PMID:20182505]"}
{"concept_id": "C2752258", "aliases": ["hypoxanthine riboside transport"], "types": ["T043"], "canonical_name": "inosine transport", "definition": "The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [PMID:19135251]"}
{"concept_id": "C2752259", "aliases": ["regulation of hypoxanthine riboside transport"], "types": ["T044"], "canonical_name": "regulation of inosine transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf]"}
{"concept_id": "C2752260", "aliases": ["positive regulation of hypoxanthine riboside transport"], "types": ["T044"], "canonical_name": "positive regulation of inosine transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf]"}
{"concept_id": "C2752261", "aliases": ["negative regulation of hypoxanthine riboside transport"], "types": ["T044"], "canonical_name": "negative regulation of inosine transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf]"}
{"concept_id": "C2752262", "aliases": ["6-hydroxypurine transport", "hypoxanthine transmembrane transport"], "types": ["T043"], "canonical_name": "hypoxanthine transport", "definition": "The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:sl]"}
{"concept_id": "C2752263", "aliases": ["regulation of 6-hydroxypurine transport"], "types": ["T044"], "canonical_name": "regulation of hypoxanthine transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf]"}
{"concept_id": "C2752264", "aliases": ["positive regulation of 6-hydroxypurine transport"], "types": ["T044"], "canonical_name": "positive regulation of hypoxanthine transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf]"}
{"concept_id": "C2752265", "aliases": ["negative regulation of 6-hydroxypurine transport"], "types": ["T044"], "canonical_name": "negative regulation of hypoxanthine transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf]"}
{"concept_id": "C2752266", "aliases": ["acetyl-CoA membrane transport"], "types": ["T044"], "canonical_name": "acetyl-CoA transmembrane transport", "definition": "The process in which acetyl-CoA is transported across a membrane. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. [GO:bf]"}
{"concept_id": "C2752267", "aliases": ["coenzyme A membrane transport"], "types": ["T043"], "canonical_name": "coenzyme A transmembrane transport", "definition": "The process in which coenzyme A is transported across a membrane. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [GOC:bf]"}
{"concept_id": "C2752268", "aliases": ["FAD membrane transport"], "types": ["T043"], "canonical_name": "FAD transmembrane transport", "definition": "The process in which flavin-adenine dinucleotide (FAD) is transported across a membrane. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. [GOC:bf, ISBN:0198506732]"}
{"concept_id": "C2752269", "aliases": ["heme membrane transport"], "types": ["T043"], "canonical_name": "heme transmembrane transport", "definition": "The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:bf]"}
{"concept_id": "C2752270", "aliases": ["NAD membrane transport"], "types": ["T043"], "canonical_name": "NAD transmembrane transport", "definition": "The process in which a nicotinamide adenine dinucleotide is transported across a membrane; transport may be of either the oxidized form, NAD, or the reduced form, NADH. [GOC:bf]"}
{"concept_id": "C2752271", "aliases": ["nicotinamide mononucleotide membrane transport"], "types": ["T043"], "canonical_name": "nicotinamide mononucleotide transmembrane transport", "definition": "The process in which nicotinamide mononucleotide is transported across a membrane. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP. [GOC:bf, ISBN:0721662544]"}
{"concept_id": "C2752272", "aliases": ["TLR1:TLR2 complex location", "TLR1-TLR2 protein complex", "Toll-like receptor 1-Toll-like receptor 2 protein complex location", "toll-like receptor TLR1:TLR2 heterodimeric complex location", "TLR1:TLR2 complex", "toll-like receptor TLR1:TLR2 heterodimeric complex", "TLR2:TLR1 heterodimer", "TLR1-TLR2 protein complex location"], "types": ["T026"], "canonical_name": "Toll-like receptor 1-Toll-like receptor 2 protein complex", "definition": "A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2). [GOC:add, GOC:signaling, PMID:17889651, PMID:21481769]"}
{"concept_id": "C2752273", "aliases": ["TLR6:TLR2 complex location", "TLR6:TLR2 complex", "TLR2-TLR6 protein complex location", "Toll-like receptor 2-Toll-like receptor 6 protein complex location", "TLR2-TLR6 protein complex", "TLR2:TLR6 heterodimer", "toll-like receptor TLR6:TLR2 heterodimeric complex", "toll-like receptor TLR6:TLR2 heterodimeric complex location"], "types": ["T026"], "canonical_name": "Toll-like receptor 2-Toll-like receptor 6 protein complex", "definition": "A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6). [GOC:add, GOC:signaling, PMID:19931471, PMID:21481769]"}
{"concept_id": "C2752274", "aliases": [], "types": ["T039"], "canonical_name": "cellular triglyceride homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment. [GOC:BHF]"}
{"concept_id": "C2752275", "aliases": ["PPAR signaling pathway", "peroxisome proliferator activated receptor signalling pathway", "peroxisome proliferator activated receptor signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes. [GOC:BHF, PMID:18221086]", "canonical_name": "peroxisome proliferator-activated receptor signaling pathway"}
{"concept_id": "C2752276", "aliases": ["regulation of peroxisome proliferator-activated receptor signaling pathway", "regulation of PPAR signaling pathway", "regulation of peroxisome proliferator activated receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of peroxisome proliferator activated receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. [GOC:bf]"}
{"concept_id": "C2752277", "aliases": ["negative regulation of PPAR signaling pathway", "negative regulation of peroxisome proliferator-activated receptor signaling pathway", "negative regulation of peroxisome proliferator activated receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of peroxisome proliferator activated receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. [GOC:bf]"}
{"concept_id": "C2752278", "aliases": ["positive regulation of peroxisome proliferator activated receptor signalling pathway", "positive regulation of peroxisome proliferator-activated receptor signaling pathway", "positive regulation of PPAR signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of peroxisome proliferator activated receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. [GOC:bf]"}
{"concept_id": "C2752279", "aliases": ["Cul8-RING ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "Cul8-RING ubiquitin ligase complex", "definition": "A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins. [GOC:krc, PMID:20139071]"}
{"concept_id": "C2752280", "aliases": ["protein-DNA interferon-stimulated response element complex assembly"], "types": ["T044"], "canonical_name": "protein-DNA ISRE complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA. [GOC:amm, PMID:11747630]"}
{"concept_id": "C2752281", "aliases": ["histone locus body"], "types": ["T026"], "definition": "A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body. [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235]", "canonical_name": "HLB"}
{"concept_id": "C2752282", "aliases": ["thymine transmembrane transport", "5-methyluracil transport"], "types": ["T043"], "canonical_name": "thymine transport", "definition": "The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GO:sl]"}
{"concept_id": "C2752283", "aliases": ["regulation of 5-methyluracil transport"], "types": ["T044"], "canonical_name": "regulation of thymine transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf, GOC:sl]"}
{"concept_id": "C2752284", "aliases": ["negative regulation of 5-methyluracil transport"], "types": ["T044"], "canonical_name": "negative regulation of thymine transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf, GOC:sl]"}
{"concept_id": "C2752285", "aliases": ["positive regulation of 5-methyluracil transport"], "types": ["T044"], "canonical_name": "positive regulation of thymine transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf, GOC:sl]"}
{"concept_id": "C2752286", "aliases": ["SECIS binding"], "types": ["T045"], "canonical_name": "selenocysteine insertion sequence binding", "definition": "Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation. [GOC:imk, PMID:10760958]"}
{"concept_id": "C2752287", "aliases": ["pre-B cell receptor complex location", "pre-BCR"], "types": ["T026"], "canonical_name": "pre-B cell receptor complex", "definition": "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. [GOC:add, ISBN:0781765196, PMID:16464608, PMID:17306522]"}
{"concept_id": "C2752288", "aliases": ["UBC13-UEV1A complex location"], "types": ["T026"], "canonical_name": "UBC13-UEV1A complex", "definition": "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A). [GOC:amm, PMID:16129784]"}
{"concept_id": "C2752289", "aliases": ["protein localisation to microtubule"], "types": ["T043"], "canonical_name": "protein localization to microtubule", "definition": "A process in which a protein is transported to, or maintained at, a microtubule. [GOC:bf, GOC:lb]"}
{"concept_id": "C2752290", "aliases": [], "types": ["T044"], "canonical_name": "chondroitin sulfate proteoglycan binding", "definition": "Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit. [GOC:kmv, ISBN:0198506732]"}
{"concept_id": "C2752291", "aliases": [], "types": ["T044"], "canonical_name": "chondroitin sulfate binding", "definition": "Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). [GOC:kmv, ISBN:0198506732]"}
{"concept_id": "C2752292", "aliases": [], "types": ["T044"], "canonical_name": "zymogen binding", "definition": "Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis. [ISBN:0198506732]"}
{"concept_id": "C2752293", "aliases": [], "types": ["T044"], "canonical_name": "proenzyme binding"}
{"concept_id": "C2752294", "aliases": ["sterol influx", "sterol uptake"], "types": ["T043"], "canonical_name": "sterol import", "definition": "The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:bf, PMID:19793923]"}
{"concept_id": "C2752295", "aliases": [], "types": ["T043"], "canonical_name": "transepithelial water transport", "definition": "The directed movement of water (H2O) from one side of an epithelium to the other. [GOC:yaf]"}
{"concept_id": "C2752296", "aliases": ["carbon dioxide membrane transport"], "types": ["T044"], "canonical_name": "carbon dioxide transmembrane transport", "definition": "The process in which carbon dioxide (CO2) is transported across a membrane. [GOC:yaf]"}
{"concept_id": "C2752297", "aliases": [], "types": ["T044"], "canonical_name": "carbon dioxide transmembrane transporter activity", "definition": "Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other. [GOC:yaf]"}
{"concept_id": "C2752298", "aliases": ["very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity"], "types": ["T044"], "canonical_name": "very long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "definition": "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. [GOC:pde]"}
{"concept_id": "C2752299", "aliases": [], "types": ["T044"], "canonical_name": "ATP-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. [GOC:bf]"}
{"concept_id": "C2752300", "aliases": ["sterol membrane transport"], "types": ["T044"], "canonical_name": "sterol transmembrane transport", "definition": "The process in which a sterol is transported across a membrane. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:vw]"}
{"concept_id": "C2752301", "aliases": ["thioester metabolism"], "types": ["T043"], "canonical_name": "thioester metabolic process", "definition": "The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. [GOC:bf, Wikipedia:Thioester]"}
{"concept_id": "C2752302", "aliases": ["thioester formation", "thioester anabolism", "thioester biosynthesis", "thioester synthesis"], "types": ["T043"], "canonical_name": "thioester biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. [GOC:bf, http://encyclopedia.thefreedictionary.com/Thioester]"}
{"concept_id": "C2752303", "aliases": ["Roundabout signalling pathway", "ROBO signaling pathway", "ROBO/SLIT signaling pathway"], "types": ["T044"], "canonical_name": "Roundabout signaling pathway", "definition": "The series of molecular signals initiated by a SLIT protein binding to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling]"}
{"concept_id": "C2752304", "aliases": ["regulation of Roundabout signalling pathway"], "types": ["T044"], "canonical_name": "regulation of Roundabout signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway. [GOC:BHF]"}
{"concept_id": "C2752305", "aliases": ["negative regulation of Roundabout signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of Roundabout signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway. [GOC:BHF]"}
{"concept_id": "C2752306", "aliases": ["positive regulation of Roundabout signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of Roundabout signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway. [GOC:BHF]"}
{"concept_id": "C2752307", "aliases": [], "types": ["T043"], "canonical_name": "establishment of chromatin silencing at silent mating-type cassette"}
{"concept_id": "C2752311", "aliases": ["MIG production", "CXCL9 production", "Monokine induced by gamma interferon production"], "types": ["T040"], "canonical_name": "chemokine (C-X-C motif) ligand 9 production", "definition": "The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add]"}
{"concept_id": "C2752312", "aliases": ["regulation of MIG production", "regulation of CXCL9 production"], "types": ["T040"], "canonical_name": "regulation of chemokine (C-X-C motif) ligand 9 production", "definition": "Any process that modulates the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9. [GOC:bf]"}
{"concept_id": "C2752313", "aliases": ["negative regulation of CXCL9 production", "negative regulation of MIG production"], "types": ["T040"], "canonical_name": "negative regulation of chemokine (C-X-C motif) ligand 9 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9. [GOC:bf]"}
{"concept_id": "C2752314", "aliases": ["positive regulation of CXCL9 production", "positive regulation of MIG production"], "types": ["T040"], "canonical_name": "positive regulation of chemokine (C-X-C motif) ligand 9 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9. [GOC:bf]"}
{"concept_id": "C2752315", "aliases": ["provision of T cell help"], "types": ["T040"], "canonical_name": "helper T cell enhancement of adaptive immune response", "definition": "Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell. [GOC:add]"}
{"concept_id": "C2752316", "aliases": ["helper T cell enhancement of T cell mediated immunity", "provision of T cell help to T cell"], "types": ["T040"], "canonical_name": "helper T cell enhancement of T cell mediated immune response", "definition": "Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell. [GOC:add]"}
{"concept_id": "C2752317", "aliases": ["provision of T cell help to B cell", "helper T cell enhancement of B cell mediated immunity"], "types": ["T040"], "canonical_name": "helper T cell enhancement of B cell mediated immune response", "definition": "Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell. [GOC:add]"}
{"concept_id": "C2752318", "aliases": ["histone-tyrosine kinase activity"], "types": ["T044"], "canonical_name": "histone tyrosine kinase activity", "definition": "Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone. [GOC:bf]"}
{"concept_id": "C2752319", "aliases": ["histone tyrosine kinase activity (H3-Y41 specific)", "histone-tyrosine kinase activity (H3-Y41 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H3-Y41 specific)", "definition": "Catalysis of the transfer of a phosphate group to the tyrosine-41 residue of histone H3. [GOC:bf]"}
{"concept_id": "C2752320", "aliases": ["histone threonine kinase activity (H3-T11 specific)", "histone-threonine kinase activity (H3-T11 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H3-T11 specific)", "definition": "Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3. [GOC:bf]"}
{"concept_id": "C2752321", "aliases": ["histone threonine kinase activity (H3-T6 specific)", "histone-threonine kinase activity (H3-T6 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H3-T6 specific)", "definition": "Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3. [GOC:bf]"}
{"concept_id": "C2752322", "aliases": ["histone serine phosphorylation"], "types": ["T044"], "canonical_name": "histone-serine phosphorylation", "definition": "The modification of histones by addition of a phosphate group to a serine residue. [GOC:bf]"}
{"concept_id": "C2752323", "aliases": ["histone threonine phosphorylation"], "types": ["T044"], "canonical_name": "histone-threonine phosphorylation", "definition": "The modification of histones by addition of a phosphate group to a threonine residue. [GOC:bf]"}
{"concept_id": "C2752324", "aliases": ["histone tyrosine phosphorylation"], "types": ["T044"], "canonical_name": "histone-tyrosine phosphorylation", "definition": "The modification of histones by addition of a phosphate group to a tyrosine residue. [GOC:bf]"}
{"concept_id": "C2752325", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-T11 phosphorylation", "definition": "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone. [GOC:bf]"}
{"concept_id": "C2752326", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-T6 phosphorylation", "definition": "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone. [GOC:bf]"}
{"concept_id": "C2752327", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-Y41 phosphorylation", "definition": "The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone. [GOC:bf]"}
{"concept_id": "C2752328", "aliases": [], "types": ["T044"], "canonical_name": "dihydrotestosterone 17-beta-dehydrogenase activity", "definition": "Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH. [GOC:ecd, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.1.1.63, PMID:4152755]"}
{"concept_id": "C2752336", "aliases": ["protein localisation to synapse"], "types": ["T043"], "canonical_name": "protein localization to synapse", "definition": "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:bf]"}
{"concept_id": "C2752343", "aliases": ["extracellular matrix-cell signalling", "cell-extracellular matrix signalling"], "types": ["T043"], "canonical_name": "extracellular matrix-cell signaling", "definition": "Any process that mediates the transfer of information between the extracellular matrix and a cell. [GOC:bf]"}
{"concept_id": "C2752346", "aliases": ["cuticular attachment to epithelium"], "types": ["T042"], "canonical_name": "cuticular attachment to epithelium"}
{"concept_id": "C2752347", "aliases": [], "types": ["T040"], "canonical_name": "activation of vulval development"}
{"concept_id": "C2752348", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of vulval development"}
{"concept_id": "C2752349", "aliases": ["upregulation of vulval development", "up-regulation of vulval development"], "types": ["T040"], "canonical_name": "up regulation of vulval development"}
{"concept_id": "C2752351", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of vulval development"}
{"concept_id": "C2752352", "aliases": ["IL12RB1-IL12RB2 complex location"], "types": ["T026"], "canonical_name": "IL12RB1-IL12RB2 complex"}
{"concept_id": "C2752353", "aliases": [], "types": ["T043"], "canonical_name": "adult eye photoreceptor development"}
{"concept_id": "C2752354", "aliases": ["nuclear membrane-endoplasmic reticulum continuum", "nuclear membrane-ER network"], "types": ["T026"], "canonical_name": "nuclear outer membrane-endoplasmic reticulum membrane network", "definition": "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]"}
{"concept_id": "C2752355", "aliases": [], "types": ["T042"], "canonical_name": "establishment of planar polarity of follicular epithelium", "definition": "Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates. [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]"}
{"concept_id": "C2752356", "aliases": [], "types": ["T043"], "canonical_name": "establishment of planar polarity of embryonic epithelium", "definition": "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates. [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C2752357", "aliases": [], "types": ["T042"], "canonical_name": "establishment of planar polarity of larval imaginal disc epithelium", "definition": "Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates. [GOC:jl]"}
{"concept_id": "C2752358", "aliases": [], "types": ["T043"], "canonical_name": "neuron guidance"}
{"concept_id": "C2752359", "aliases": ["cuticle biosynthetic process during molting", "cuticle synthesis during molting", "cuticle anabolism during molting", "cuticle formation during molting"], "types": ["T040"], "canonical_name": "cuticle anabolism during molting"}
{"concept_id": "C2752360", "aliases": [], "types": ["T043"], "canonical_name": "non-eye photoreceptor development"}
{"concept_id": "C2752361", "aliases": [], "types": ["T043"], "canonical_name": "perception of triacylated bacterial lipopeptide"}
{"concept_id": "C2752362", "aliases": ["triacylated lipopeptide binding"], "types": ["T044"], "canonical_name": "triacyl lipopeptide binding", "definition": "Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]"}
{"concept_id": "C2752363", "aliases": [], "types": ["T043"], "canonical_name": "perception of diacylated bacterial lipopeptide"}
{"concept_id": "C2752364", "aliases": [], "types": ["T044"], "canonical_name": "bacterial triacyl lipopeptide binding"}
{"concept_id": "C2752365", "aliases": [], "types": ["T044"], "canonical_name": "bacterial diacyl lipopeptide binding"}
{"concept_id": "C2752366", "aliases": ["NADH dehydrogenase (ubiquinone) complex location, peripheral segment"], "types": ["T026"], "canonical_name": "NADH dehydrogenase (ubiquinone) complex, peripheral segment"}
{"concept_id": "C2752367", "aliases": ["NADH-Q oxidoreductase complex location, peripheral segment"], "types": ["T026"], "canonical_name": "NADH-Q oxidoreductase complex, peripheral segment"}
{"concept_id": "C2752368", "aliases": ["NADH-Q oxidoreductase complex location, membrane segment"], "types": ["T026"], "canonical_name": "NADH-Q oxidoreductase complex, membrane segment"}
{"concept_id": "C2752369", "aliases": ["hydrogen peroxide scavenging"], "types": ["T044"], "canonical_name": "H2O2 scavenging"}
{"concept_id": "C2752373", "aliases": [], "types": ["T043"], "definition": "The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells. [GOC:mah]", "canonical_name": "cell wall assembly"}
{"concept_id": "C2752374", "aliases": ["cell wall synthesis", "cell wall anabolism", "cell wall biosynthetic process", "cell wall formation"], "types": ["T043"], "canonical_name": "cell wall anabolism"}
{"concept_id": "C2752375", "aliases": [], "types": ["T043"], "canonical_name": "Gram-negative-bacterium-type cell outer membrane assembly", "definition": "The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. [GOC:jl, ISBN:0135712254]"}
{"concept_id": "C2752376", "aliases": [], "types": ["T026"], "canonical_name": "Schwann cell myelin sheath"}
{"concept_id": "C2752377", "aliases": [], "types": ["T026"], "canonical_name": "Schwann cell compact myelin"}
{"concept_id": "C2752379", "aliases": [], "types": ["T044"], "canonical_name": "26S proteasome assembly"}
{"concept_id": "C2752380", "aliases": [], "types": ["T042"], "canonical_name": "skeletal muscle tissue regeneration", "definition": "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119]"}
{"concept_id": "C2752381", "aliases": [], "types": ["T044"], "canonical_name": "macromolecule modification", "definition": "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. [GOC:go_curators]"}
{"concept_id": "C2752382", "aliases": [], "types": ["T070"], "canonical_name": "macromolecule glycosylation", "definition": "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. [GOC:jl]"}
{"concept_id": "C2752383", "aliases": [], "types": ["T070"], "canonical_name": "macromolecule methylation", "definition": "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. [GOC:go_curators]"}
{"concept_id": "C2752384", "aliases": [], "types": ["T038"], "canonical_name": "regulation of skeletal muscle tissue regeneration", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle. [GOC:jl]"}
{"concept_id": "C2752385", "aliases": ["histone chaperone", "histone chaperone activity"], "types": ["T044"], "definition": "Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone). [PMID:26459557]", "canonical_name": "histone carrier activity"}
{"concept_id": "C2752386", "aliases": ["CLRC ubiquitin ligase complex", "Rik1 E3 ubiquitin ligase complex location", "Rik1-E3 ubiquitin ligase complex location", "Rik1-E3 ubiquitin ligase complex", "Rik1 E3 ubiquitin ligase complex", "CLRC complex location", "CLRC ubiquitin ligase complex location", "Clr4-Rik1-Cul4 complex", "Clr4-Rik1-Cul4 complex location"], "types": ["T026"], "canonical_name": "CLRC complex", "definition": "An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi. [GOC:vw, PMID:16127433, PMID:20211136]"}
{"concept_id": "C2752388", "aliases": [], "types": ["T045"], "canonical_name": "polyadenylation-dependent RNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA. [GOC:dgf, GOC:jl, GOC:krc]"}
{"concept_id": "C2752389", "aliases": [], "types": ["T026"], "canonical_name": "axon terminal specialization"}
{"concept_id": "C2752393", "aliases": [], "types": ["T044"], "canonical_name": "2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity", "definition": "Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O. [GOC:jl, MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN]"}
{"concept_id": "C2752394", "aliases": ["cellular cell wall macromolecule metabolic process", "cellular cell wall macromolecule metabolism"], "types": ["T044"], "canonical_name": "cell wall macromolecule metabolic process", "definition": "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. [GOC:jl, GOC:mah]"}
{"concept_id": "C2752396", "aliases": ["cell wall macromolecule synthesis", "cellular cell wall macromolecule biosynthetic process", "cell wall macromolecule biosynthesis", "cell wall macromolecule anabolism", "cell wall macromolecule biosynthetic process at cellular level"], "types": ["T043"], "canonical_name": "cell wall macromolecule biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall. [GOC:go_curators]"}
{"concept_id": "C2752398", "aliases": ["regulation by symbiont of host vacuole organization", "modulation of host vacuole organization by symbiont", "modulation by symbiont of host vacuole organisation"], "types": ["T040"], "canonical_name": "modulation by symbiont of host vacuole organization", "definition": "Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism. [MITRE:tk]"}
{"concept_id": "C2752400", "aliases": [], "types": ["T043"], "canonical_name": "activation of terminal complement complex"}
{"concept_id": "C2752405", "aliases": [], "types": ["T043"], "canonical_name": "intestinal D-glucose absorption", "definition": "Uptake of D-glucose into the blood by absorption from the small intestine. [GOC:mgi_curators, PMID:5601832]"}
{"concept_id": "C2752406", "aliases": ["regulation of activation of terminal complement complex"], "types": ["T043"], "canonical_name": "regulation of activation of TCC"}
{"concept_id": "C2752407", "aliases": [], "types": ["T043"], "canonical_name": "regulation of activation of the terminal complement cascade"}
{"concept_id": "C2752410", "aliases": ["positive regulation of host vacuole organization by symbiont", "positive regulation by symbiont of host vacuole organisation"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host vacuole organization", "definition": "The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism. [MITRE:tk]"}
{"concept_id": "C2752411", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of molecular function", "definition": "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. [GO:jl]"}
{"concept_id": "C2752412", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of molecular function", "definition": "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. [GO:jl]"}
{"concept_id": "C2752413", "aliases": [], "types": ["T026"], "canonical_name": "host cell nuclear part", "definition": "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction. [GOC:ecd]"}
{"concept_id": "C2752414", "aliases": [], "types": ["T026"], "canonical_name": "host cell nucleoplasm", "definition": "That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction. [GOC:ecd]"}
{"concept_id": "C2752415", "aliases": ["type IV pilus", "type 4 pilus", "TFP"], "types": ["T026"], "definition": "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. [GOC:pamgo_curators, PMID:28496159]", "canonical_name": "type IV fimbriae"}
{"concept_id": "C2752416", "aliases": ["secretion via the type IV secretion system"], "types": ["T043"], "canonical_name": "secretion by the type IV secretion system", "definition": "The controlled release of proteins or DNA by a cell, via the type IV secretion system. [GOC:pamgo_curators]"}
{"concept_id": "C2752417", "aliases": ["DNA secretion via the type IV secretion system"], "types": ["T043"], "canonical_name": "DNA secretion by the type IV secretion system", "definition": "The controlled release of DNA by a cell, via the type IV secretion system. [GOC:pamgo_curators]"}
{"concept_id": "C2752418", "aliases": [], "types": ["T026"], "canonical_name": "polar tube", "definition": "A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell. [GOC:mf, PMID:12076771, PMID:9723921]"}
{"concept_id": "C2752419", "aliases": [], "types": ["T026"], "canonical_name": "sporoplasm", "definition": "The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms. [GOC:mf, PMID:12076771, PMID:16004371, PMID:9723921]"}
{"concept_id": "C2752420", "aliases": ["(R)-citramalyl-CoA lyase activity", "Ccl"], "types": ["T044"], "definition": "Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA. [GOC:jl]", "canonical_name": "R-citramalyl-CoA lyase activity"}
{"concept_id": "C2752421", "aliases": [], "types": ["T044"], "canonical_name": "L-arabinose 1-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+. [GOC:jl, PMID:16326697]"}
{"concept_id": "C2752422", "aliases": ["2,5-dioxopentanoate dehydrogenase (NAD+) activity", "2,5-dioxopentanoate:NAD+ 5-oxidoreductase activity"], "types": ["T044"], "canonical_name": "2,5-dioxovalerate dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+. [PMID:16835232, PMID:17202142]"}
{"concept_id": "C2752423", "aliases": [], "types": ["T044"], "canonical_name": "L-xylulose reductase (NAD+) activity", "definition": "Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+. [PMID:14736891]"}
{"concept_id": "C2752424", "aliases": [], "types": ["T044"], "canonical_name": "cellular amine metabolic process", "definition": "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl]"}
{"concept_id": "C2752425", "aliases": [], "types": ["T044"], "canonical_name": "cellular alcohol metabolic process", "definition": "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells. [GOC:jl]"}
{"concept_id": "C2752426", "aliases": ["cellular alcohol catabolic process"], "types": ["T043"], "canonical_name": "cellular alcohol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell. [GOC:jl]"}
{"concept_id": "C2752427", "aliases": [], "types": ["T040"], "canonical_name": "development during symbiotic interaction"}
{"concept_id": "C2752429", "aliases": [], "types": ["T040"], "canonical_name": "development of symbiont in host", "definition": "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:jl, GOC:pamgo_curators]"}
{"concept_id": "C2752431", "aliases": [], "types": ["T040"], "canonical_name": "development of symbiont in host vascular tissue"}
{"concept_id": "C2752432", "aliases": [], "types": ["T040"], "canonical_name": "development of symbiont in host intercellular space"}
{"concept_id": "C2752433", "aliases": [], "types": ["T040"], "canonical_name": "regulation of development of symbiont in host", "definition": "Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction. [GOC:jl, GOC:pamgo_curators]"}
{"concept_id": "C2752434", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of development of symbiont in host", "definition": "Any process in which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction. [GOC:jl, GOC:pamgo_curators]"}
{"concept_id": "C2752435", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of development of symbiont in host", "definition": "Any process in which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction. [GOC:jl, GOC:pamgo_curators]"}
{"concept_id": "C2752442", "aliases": [], "types": ["T040"], "canonical_name": "modulation of development of symbiont during interaction with host"}
{"concept_id": "C2752443", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of development of symbiont during interaction with host"}
{"concept_id": "C2752444", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of development of symbiont during interaction with host"}
{"concept_id": "C2752447", "aliases": ["histone H3K14 acetylation", "histone H3 acetylation at K14"], "types": ["T044"], "canonical_name": "histone H3-K14 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone. [GOC:jl, GOC:lb, PMID:17194708]"}
{"concept_id": "C2752448", "aliases": [], "types": ["T026"], "canonical_name": "host caveola", "definition": "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:rph]"}
{"concept_id": "C2752449", "aliases": [], "types": ["T026"], "canonical_name": "host cell junction", "definition": "A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. [GOC:rph]"}
{"concept_id": "C2752450", "aliases": [], "types": ["T026"], "canonical_name": "host cell projection", "definition": "A prolongation or process extending from a host cell, e.g. a flagellum or axon. [GOC:rph]"}
{"concept_id": "C2752451", "aliases": [], "types": ["T026"], "canonical_name": "host cell wall", "definition": "The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. [GOC:rph]"}
{"concept_id": "C2752452", "aliases": [], "types": ["T026"], "canonical_name": "host thylakoid", "definition": "A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. [GOC:rph]"}
{"concept_id": "C2752453", "aliases": [], "types": ["T026"], "canonical_name": "host thylakoid membrane", "definition": "The pigmented membrane of any host thylakoid. [GOC:rph]"}
{"concept_id": "C2752454", "aliases": [], "types": ["T026"], "canonical_name": "host cell cytoplasmic vesicle", "definition": "A vesicle formed of membrane or protein, found in the cytoplasm of a host cell. [GOC:rph]"}
{"concept_id": "C2752455", "aliases": [], "types": ["T026"], "canonical_name": "host cell cytoplasmic vesicle membrane", "definition": "The lipid bilayer surrounding a host cell cytoplasmic vesicle. [GOC:rph]"}
{"concept_id": "C2752456", "aliases": [], "types": ["T026"], "canonical_name": "host cytoskeleton", "definition": "A cellular structure that forms the internal framework of eukaryotic and prokaryotic host cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:rph]"}
{"concept_id": "C2752457", "aliases": ["host cytosol"], "types": ["T026"], "canonical_name": "host cell cytosol", "definition": "The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:jl]"}
{"concept_id": "C2752458", "aliases": ["host endoplasmic reticulum"], "types": ["T026"], "canonical_name": "host cell endoplasmic reticulum", "definition": "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [GOC:jl]"}
{"concept_id": "C2752459", "aliases": ["host endoplasmic reticulum lumen"], "types": ["T026"], "canonical_name": "host cell endoplasmic reticulum lumen", "definition": "The volume enclosed by the membranes of the host cell endoplasmic reticulum. [GOC:jl]"}
{"concept_id": "C2752460", "aliases": ["host endoplasmic reticulum membrane"], "types": ["T026"], "canonical_name": "host cell endoplasmic reticulum membrane", "definition": "The lipid bilayer surrounding the host cell endoplasmic reticulum. [GOC:jl]"}
{"concept_id": "C2752461", "aliases": ["host rough endoplasmic reticulum"], "types": ["T026"], "canonical_name": "host cell rough endoplasmic reticulum", "definition": "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface. [GOC:jl]"}
{"concept_id": "C2752462", "aliases": ["host rough endoplasmic reticulum membrane"], "types": ["T026"], "canonical_name": "host cell rough endoplasmic reticulum membrane", "definition": "The lipid bilayer surrounding the host cell rough endoplasmic reticulum. [GOC:jl]"}
{"concept_id": "C2752463", "aliases": ["host smooth endoplasmic reticulum"], "types": ["T026"], "canonical_name": "host cell smooth endoplasmic reticulum", "definition": "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface. [GOC:jl]"}
{"concept_id": "C2752464", "aliases": ["host smooth endoplasmic reticulum membrane"], "types": ["T026"], "canonical_name": "host cell smooth endoplasmic reticulum membrane", "definition": "The lipid bilayer surrounding the host cell smooth endoplasmic reticulum. [GOC:jl]"}
{"concept_id": "C2752465", "aliases": ["host ER-Golgi intermediate compartment", "host cell ER-Golgi intermediate compartment"], "types": ["T026"], "canonical_name": "host cell endoplasmic reticulum-Golgi intermediate compartment", "definition": "A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport. [GOC:jl, GOC:pr]"}
{"concept_id": "C2752466", "aliases": ["host cell ER-Golgi intermediate compartment membrane", "host ER-Golgi intermediate compartment membrane", "host endoplasmic reticulum-Golgi intermediate compartment membrane"], "types": ["T026"], "canonical_name": "host cell endoplasmic reticulum-Golgi intermediate compartment membrane", "definition": "The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system. [GOC:jl]"}
{"concept_id": "C2752467", "aliases": ["host endosome"], "types": ["T026"], "canonical_name": "host cell endosome", "definition": "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation. [GOC:jl]"}
{"concept_id": "C2752468", "aliases": ["host endosome membrane"], "types": ["T026"], "canonical_name": "host cell endosome membrane", "definition": "The lipid bilayer surrounding a host cell endosome. [GOC:jl]"}
{"concept_id": "C2752469", "aliases": ["host filopodium"], "types": ["T026"], "canonical_name": "host cell filopodium", "definition": "Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. [GOC:jl]"}
{"concept_id": "C2752470", "aliases": ["host Golgi apparatus"], "types": ["T026"], "canonical_name": "host cell Golgi apparatus", "definition": "A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. [GOC:jl]"}
{"concept_id": "C2752471", "aliases": ["host Golgi membrane"], "types": ["T026"], "canonical_name": "host cell Golgi membrane", "definition": "The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus. [GOC:jl]"}
{"concept_id": "C2752472", "aliases": ["hemolysis of erythrocytes in other organism", "hemolysis of red blood cells in other organism", "hemolysis of cells in other organism", "hemolysis in other organism", "hemolysis of RBCs in other organism"], "types": ["T043"], "canonical_name": "hemolysis in another organism", "definition": "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another. [GOC:jl]"}
{"concept_id": "C2752473", "aliases": [], "types": ["T043"], "canonical_name": "filamentous growth of a unicellular organism", "definition": "The process in which a unicellular organism grows in a threadlike, filamentous shape. [GOC:mtg_cambridge_2009]"}
{"concept_id": "C2752474", "aliases": [], "types": ["T043"], "canonical_name": "filamentous growth of a multicellular organism", "definition": "The process in which a multicellular organism grows in a threadlike, filamentous shape. [GOC:mtg_cambridge_2009]"}
{"concept_id": "C2752475", "aliases": [], "types": ["T043"], "canonical_name": "filamentous growth of a population of unicellular organisms", "definition": "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape. [GOC:mtg_cambridge_2009]"}
{"concept_id": "C2752476", "aliases": ["protein binding involved in protein folding"], "types": ["T044"], "canonical_name": "protein folding chaperone", "definition": "Binding to a protein or a protein-containing complex to assist the protein folding process. [GOC:mtg_cambridge_2009]"}
{"concept_id": "C2752477", "aliases": [], "types": ["T026"], "canonical_name": "host cell late endosome", "definition": "A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. [GOC:jl]"}
{"concept_id": "C2752478", "aliases": [], "types": ["T026"], "canonical_name": "host cell late endosome membrane", "definition": "The lipid bilayer surrounding a host cell late endosome. [GOC:jl]"}
{"concept_id": "C2752479", "aliases": ["host cell lipid particle", "host cell lipid adiposome", "host cell lipid body"], "types": ["T026"], "canonical_name": "host cell lipid droplet", "definition": "Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins. [GOC:jl]"}
{"concept_id": "C2752480", "aliases": [], "types": ["T026"], "canonical_name": "host cell lysosome", "definition": "A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions. [GOC:jl]"}
{"concept_id": "C2752481", "aliases": [], "types": ["T026"], "canonical_name": "host cell lysosomal membrane", "definition": "The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm. [GOC:jl]"}
{"concept_id": "C2752483", "aliases": [], "types": ["T026"], "canonical_name": "host cell mitochondrial envelope", "definition": "The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space. [GOC:jl]"}
{"concept_id": "C2752484", "aliases": [], "types": ["T026"], "canonical_name": "host cell mitochondrial membrane", "definition": "Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope. [GOC:jl]"}
{"concept_id": "C2752485", "aliases": [], "types": ["T026"], "canonical_name": "host cell mitochondrial inner membrane", "definition": "The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae. [GOC:jl]"}
{"concept_id": "C2752486", "aliases": [], "types": ["T026"], "canonical_name": "host cell mitochondrial outer membrane", "definition": "The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope. [GOC:jl]"}
{"concept_id": "C2752487", "aliases": [], "types": ["T026"], "canonical_name": "cytolytic granule", "definition": "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. [GOC:jl, PMID:11052265, PMID:12766758]"}
{"concept_id": "C2752488", "aliases": ["nuclear channels"], "types": ["T026"], "canonical_name": "nucleoplasmic reticulum", "definition": "Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport. [GOC:jl, PMID:17959832, PMID:9024685]"}
{"concept_id": "C2752489", "aliases": [], "types": ["T026"], "canonical_name": "host cell nucleolus", "definition": "A small, dense body one or more of which are present in the nucleus of eukaryotic host cells. [GOC:jl]"}
{"concept_id": "C2752490", "aliases": ["RHD binding"], "types": ["T044"], "canonical_name": "Rel homology domain binding", "definition": "Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT. [InterPro:IPR011539, Wikipedia:Rel_homology_domain]"}
{"concept_id": "C2752491", "aliases": ["TRAF-type zinc finger domain binding", "zinc-finger-TRAF domain binding", "zinc finger TRAF-type domain binding"], "types": ["T044"], "canonical_name": "zf-TRAF domain binding", "definition": "Binding to a TRAF-type zinc finger domain of a protein. [InterPro:IPR001293]"}
{"concept_id": "C2752492", "aliases": [], "types": ["T026"], "canonical_name": "host cell nuclear envelope", "definition": "The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [GOC:jl]"}
{"concept_id": "C2752493", "aliases": [], "types": ["T026"], "canonical_name": "host cell nuclear membrane", "definition": "Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:jl]"}
{"concept_id": "C2752494", "aliases": [], "types": ["T026"], "canonical_name": "host cell nuclear inner membrane", "definition": "The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope. [GOC:jl]"}
{"concept_id": "C2752495", "aliases": [], "types": ["T026"], "canonical_name": "host cell nuclear outer membrane", "definition": "The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes. [GOC:jl]"}
{"concept_id": "C2752496", "aliases": [], "types": ["T026"], "canonical_name": "host cell nuclear lamina", "definition": "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments. [GOC:jl]"}
{"concept_id": "C2752497", "aliases": [], "types": ["T026"], "canonical_name": "host cell nuclear matrix", "definition": "The dense fibrillar network lying on the inner side of the host nuclear membrane. [GOC:jl]"}
{"concept_id": "C2752498", "aliases": ["'de novo' UMP biosynthesis"], "types": ["T044"], "canonical_name": "'de novo' UMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen. [GOC:ecd, GOC:jl]"}
{"concept_id": "C2752499", "aliases": ["UMP biosynthetic process via nucleoside salvage pathway", "UMP biosynthesis via nucleoside salvage pathway"], "types": ["T044"], "canonical_name": "UMP salvage", "definition": "Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis. [GOC:ecd, PMID:15096496]"}
{"concept_id": "C2752500", "aliases": ["translation initiation (ternary) complex", "translation initiation (ternary) complex location", "translation initiation ternary complex location"], "types": ["T026"], "canonical_name": "translation initiation ternary complex", "definition": "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). [GOC:jl]"}
{"concept_id": "C2752501", "aliases": ["Met-tRNA/eIF2.GTP ternary complex location"], "types": ["T026"], "canonical_name": "Met-tRNA/eIF2.GTP ternary complex"}
{"concept_id": "C2752502", "aliases": [], "types": ["T044"], "canonical_name": "'de novo' AMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). [GOC:ecd, PMID:10888601]"}
{"concept_id": "C2752503", "aliases": ["AMP biosynthetic process via salvage pathway", "adenosine monophosphate salvage"], "types": ["T044"], "canonical_name": "AMP salvage", "definition": "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis. [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350]"}
{"concept_id": "C2752504", "aliases": ["'de novo' cytidine 5'-triphosphate biosynthetic process"], "types": ["T044"], "canonical_name": "'de novo' CTP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components. [GOC:ecd, GOC:jl, PMID:11912132, PMID:18439916]"}
{"concept_id": "C2752505", "aliases": ["cytidine 5'-triphosphate salvage", "CTP biosynthetic process via salvage pathway"], "types": ["T044"], "canonical_name": "CTP salvage", "definition": "Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis. [GOC:ecd, GOC:jl, PMID:10501935]"}
{"concept_id": "C2752506", "aliases": [], "types": ["T045"], "canonical_name": "transcription regulatory region DNA binding"}
{"concept_id": "C2752507", "aliases": [], "types": ["T045"], "canonical_name": "intronic transcription regulatory region DNA binding"}
{"concept_id": "C2752508", "aliases": [], "types": ["T026"], "canonical_name": "transmembrane"}
{"concept_id": "C2752511", "aliases": [], "types": ["T026"], "canonical_name": "other organism part", "definition": "Any constituent part of a secondary organism with which the first organism is interacting. [GOC:jl]"}
{"concept_id": "C2752512", "aliases": ["foreign membrane"], "types": ["T026"], "canonical_name": "other organism cell membrane", "definition": "The cell membrane of a secondary organism with which the first organism is interacting. [GOC:jl]"}
{"concept_id": "C2752513", "aliases": [], "types": ["T026"], "canonical_name": "host cell plasmodesma", "definition": "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell. [GOC:rph, PMID:16903353]"}
{"concept_id": "C2752514", "aliases": [], "types": ["T026"], "canonical_name": "host cell perinuclear region of cytoplasm", "definition": "The host cell cytoplasm situated near, or occurring around, the host nucleus. [GOC:rph]"}
{"concept_id": "C2752515", "aliases": [], "types": ["T026"], "canonical_name": "host cell synapse", "definition": "The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication. [GOC:rph]"}
{"concept_id": "C2752516", "aliases": [], "types": ["T026"], "canonical_name": "anammoxosome", "definition": "An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism. [GOC:dh, PMID:17993524, PMID:19682260]"}
{"concept_id": "C2752517", "aliases": [], "types": ["T026"], "canonical_name": "pirellulosome", "definition": "A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm. [GOC:dh, PMID:19133117]"}
{"concept_id": "C2752518", "aliases": ["juxtaparanode", "juxtaparanodal region"], "types": ["T026"], "canonical_name": "juxtaparanode region of axon", "definition": "A region of an axon near a node of Ranvier that is between the paranode and internode regions. [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359]"}
{"concept_id": "C2752519", "aliases": [], "types": ["T026"], "canonical_name": "apical pole of neuron", "definition": "Portion of a neuron cell soma closest to the point where the apical dendrite emerges. [NIF_Subcellular:sao1186862860]"}
{"concept_id": "C2752520", "aliases": [], "types": ["T026"], "canonical_name": "basal pole of neuron", "definition": "Portion of a neuron cell soma closest to the point where the basilar dendrite emerges. [NIF_Subcellular:sao1186862860]"}
{"concept_id": "C2752521", "aliases": ["methanotroph intracytoplasmic membrane-bound compartment", "methane-oxidizing compartment"], "types": ["T026"], "canonical_name": "methane-oxidizing organelle", "definition": "A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms. [GOC:dh]"}
{"concept_id": "C2752522", "aliases": [], "types": ["T026"], "canonical_name": "host cell surface", "definition": "The external part of the host cell wall and/or host plasma membrane. [GOC:rph]"}
{"concept_id": "C2752523", "aliases": [], "types": ["T026"], "canonical_name": "host cell periplasmic space", "definition": "The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi). [GOC:rph]"}
{"concept_id": "C2752524", "aliases": [], "types": ["T026"], "canonical_name": "host cell envelope", "definition": "An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present. [GOC:rph]"}
{"concept_id": "C2752525", "aliases": ["host cell pre-synaptic membrane"], "types": ["T026"], "canonical_name": "host cell presynaptic membrane", "definition": "A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:rph]"}
{"concept_id": "C2752526", "aliases": ["mitochondria-associated membrane", "mitochondria-associated ER membrane", "mitochondria-associated endoplasmic reticulum membrane", "ER-mitochondrion membrane contact site", "endoplasmic reticulum-mitochondrion membrane contact site", "mitochondria-endoplasmic reticulum (ER) contact"], "types": ["T026"], "definition": "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange. [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109]", "canonical_name": "MAM"}
{"concept_id": "C2752529", "aliases": [], "types": ["T043"], "canonical_name": "intermediary metabolism"}
{"concept_id": "C2752530", "aliases": ["cellular cell wall disassembly"], "types": ["T043"], "canonical_name": "cell wall disassembly", "definition": "A process that results in the breakdown of the cell wall. [GOC:jl]"}
{"concept_id": "C2752532", "aliases": [], "types": ["T026"], "canonical_name": "other organism membrane"}
{"concept_id": "C2752533", "aliases": [], "types": ["T026"], "canonical_name": "subplasmalemmal coating", "definition": "Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier. [NIF_Subcellular:sao1938587839]"}
{"concept_id": "C2752534", "aliases": ["small molecule metabolism"], "types": ["T040"], "canonical_name": "small molecule metabolic process", "definition": "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:pde, GOC:vw]"}
{"concept_id": "C2752535", "aliases": ["small molecule catabolism"], "types": ["T040"], "canonical_name": "small molecule catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:vw]"}
{"concept_id": "C2752536", "aliases": ["small molecule biosynthesis"], "types": ["T038"], "canonical_name": "small molecule biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:pde, GOC:vw]"}
{"concept_id": "C2752537", "aliases": ["cristae junction", "crista junction"], "types": ["T026"], "canonical_name": "mitochondrial crista junction", "definition": "A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane. [GOC:mcc, PMID:21944719, PMID:21987634, PMID:22009199]"}
{"concept_id": "C2752538", "aliases": [], "types": ["T026"], "canonical_name": "bridge contact site"}
{"concept_id": "C2752539", "aliases": ["ball and socket contact"], "types": ["T030"], "canonical_name": "peg and socket contact", "definition": "A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells. [GOC:tfm, NIF_Subcellular:sao1943947957, PMID:12883993, PMID:16166562, PMID:17591898]"}
{"concept_id": "C2752540", "aliases": [], "types": ["T026"], "canonical_name": "puncta adhaerentia", "definition": "A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells. [NIF_Subcellular:sao257629430]"}
{"concept_id": "C2752541", "aliases": [], "types": ["T026"], "canonical_name": "contact site"}
{"concept_id": "C2752543", "aliases": ["cell cell contact zone", "cell-cell contact zone", "cell-cell contact region"], "types": ["T030"], "canonical_name": "cell-cell contact zone", "definition": "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. [NIF_Subcellular:sao1299635018]"}
{"concept_id": "C2752544", "aliases": ["dendrite terminal", "terminal specialization of a dendrite", "dendrite terminal specialization"], "types": ["T026"], "canonical_name": "dendrite terminus", "definition": "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole. [GOC:jl, NIF_Subcellular:sao28175134]"}
{"concept_id": "C2752545", "aliases": [], "types": ["T026"], "canonical_name": "dendriole", "definition": "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC). [GOC:jl, NIF_Subcellular:sao28175134, NIF_Subcellular:sao295057932, PMID:8300904]"}
{"concept_id": "C2752546", "aliases": ["dendrite growth cone"], "types": ["T026"], "canonical_name": "dendritic growth cone", "definition": "The migrating motile tip of a growing nerve cell dendrite. [GOC:jl]"}
{"concept_id": "C2752547", "aliases": ["axon growth cone"], "types": ["T026"], "canonical_name": "axonal growth cone", "definition": "The migrating motile tip of a growing nerve cell axon. [GOC:jl, NIF_Subcellular:sao203987954]"}
{"concept_id": "C2752548", "aliases": ["dendrite tuft"], "types": ["T026"], "canonical_name": "dendritic tuft", "definition": "The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance. [NIF_Subcellular:sao1340260079]"}
{"concept_id": "C2752549", "aliases": ["cell body"], "types": ["T026"], "definition": "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. [GOC:go_curators]", "canonical_name": "cell soma"}
{"concept_id": "C2752550", "aliases": ["cell soma membrane"], "types": ["T026"], "canonical_name": "cell body membrane", "definition": "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections. [GOC:ecd]"}
{"concept_id": "C2752551", "aliases": ["climbing fibre"], "types": ["T026"], "canonical_name": "climbing fiber", "definition": "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber. [NIF_Subcellular:nlx_subcell_20090203]"}
{"concept_id": "C2752552", "aliases": ["granule cell axon", "dentate gyrus mossy fibre"], "types": ["T026"], "canonical_name": "dentate gyrus mossy fiber", "definition": "Distinctive, unmyelinated axons produced by granule cells. [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709]"}
{"concept_id": "C2752553", "aliases": ["axon trunk"], "types": ["T026"], "canonical_name": "main axon", "definition": "The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. [NIF_Subcellular:sao1596975044]"}
{"concept_id": "C2752554", "aliases": [], "types": ["T026"], "canonical_name": "calyx of Held", "definition": "The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. [NIF_Subcellular:sao1684283879, PMID:11823805]"}
{"concept_id": "C2752555", "aliases": ["neuron projection terminal", "neuron terminal specialization"], "types": ["T026"], "canonical_name": "neuron projection terminus", "definition": "The specialized, terminal region of a neuron projection such as an axon or a dendrite. [GOC:jl]"}
{"concept_id": "C2752556", "aliases": ["dendrite branch"], "types": ["T026"], "canonical_name": "dendritic branch", "definition": "A dendrite arising from another dendrite. [GOC:aruk, GOC:bc, NIF_Subcellular:sao884265541]"}
{"concept_id": "C2752557", "aliases": ["axon spine"], "types": ["T026"], "canonical_name": "axonal spine", "definition": "A spine that originates from the axon, usually from the initial segment. [NIF_Subcellular:sao18239917]"}
{"concept_id": "C2752558", "aliases": ["spine"], "types": ["T026"], "definition": "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. [ISBN:0198504888, NIF_Subcellular:sao1145756102]", "canonical_name": "neuron spine"}
{"concept_id": "C2752559", "aliases": [], "types": ["T026"], "canonical_name": "osmiophilic body", "definition": "A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito. [GOC:jl, PMID:18086189]"}
{"concept_id": "C2752560", "aliases": [], "types": ["T026"], "canonical_name": "exoneme", "definition": "A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte. [GOC:jl, PMID:18083092, PMID:18083098]"}
{"concept_id": "C2752561", "aliases": [], "types": ["T026"], "definition": "A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation. [GOC:jl, PMID:19932717]", "canonical_name": "crystalloid"}
{"concept_id": "C2752563", "aliases": [], "types": ["T043"], "canonical_name": "invasive growth in response to pheromone", "definition": "The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus. [GOC:ai, GOC:dph, GOC:mcc]"}
{"concept_id": "C2752564", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hypodermal cell differentiation"}
{"concept_id": "C2752565", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of hypodermal cell differentiation"}
{"concept_id": "C2752566", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of hypodermal cell differentiation"}
{"concept_id": "C2752567", "aliases": [], "types": ["T042"], "canonical_name": "regulation of hypodermis development"}
{"concept_id": "C2752568", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of hypodermis development"}
{"concept_id": "C2752569", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of hypodermis development"}
{"concept_id": "C2752570", "aliases": [], "types": ["T044"], "canonical_name": "storage protein of fat body"}
{"concept_id": "C2752571", "aliases": ["regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis", "regulation of RNA polymerase II transcriptional preinitiation complex formation", "regulation of RNA polymerase II transcriptional preinitiation complex assembly", "regulation of RNA polymerase II transcriptional pre-initiation complex assembly"], "types": ["T045"], "canonical_name": "regulation of RNA polymerase II transcription preinitiation complex assembly", "definition": "Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. [GOC:go_curators]"}
{"concept_id": "C2752572", "aliases": ["positive regulation of RNA polymerase II transcriptional preinitiation complex formation", "positive regulation of RNA polymerase II transcriptional pre-initiation complex assembly", "stimulation of RNA polymerase II transcriptional preinitiation complex assembly", "positive regulation of RNA polymerase II transcriptional preinitiation complex assembly", "up regulation of RNA polymerase II transcriptional preinitiation complex assembly", "positive regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis", "up-regulation of RNA polymerase II transcriptional preinitiation complex assembly", "upregulation of RNA polymerase II transcriptional preinitiation complex assembly", "activation of RNA polymerase II transcriptional preinitiation complex assembly"], "types": ["T045"], "canonical_name": "positive regulation of RNA polymerase II transcription preinitiation complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. [GOC:go_curators]"}
{"concept_id": "C2752573", "aliases": ["positive regulation of activation of terminal complement complex"], "types": ["T043"], "canonical_name": "positive regulation of activation of TCC"}
{"concept_id": "C2752574", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of activation of the terminal complement cascade"}
{"concept_id": "C2752577", "aliases": ["negative regulation of activation of terminal complement complex"], "types": ["T043"], "canonical_name": "negative regulation of activation of TCC"}
{"concept_id": "C2752578", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of activation of the terminal complement cascade"}
{"concept_id": "C2752581", "aliases": ["vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure"], "types": ["T039"], "canonical_name": "artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure", "definition": "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure. [ISBN:0721643949]"}
{"concept_id": "C2752582", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in sprouting angiogenesis", "definition": "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. [PMID:16391003]"}
{"concept_id": "C2752583", "aliases": [], "types": ["T043"], "canonical_name": "blood vessel endothelial cell migration involved in intussusceptive angiogenesis", "definition": "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis. [PMID:16391003]"}
{"concept_id": "C2752584", "aliases": [], "types": ["T044"], "canonical_name": "secretin"}
{"concept_id": "C2752586", "aliases": ["fatty-acyl-CoA synthesis", "fatty acyl CoA biosynthetic process", "fatty-acyl-CoA anabolism", "fatty-acyl-CoA biosynthesis", "fatty-acyl-CoA formation"], "types": ["T044"], "canonical_name": "fatty-acyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. [ISBN:0198506732]"}
{"concept_id": "C2752587", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of neuroepithelial cell differentiation", "definition": "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. [GOC:dph, PMID:16678814]"}
{"concept_id": "C2752589", "aliases": ["retinoic acid anabolic process"], "types": ["T044"], "canonical_name": "retinoic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A. [GOC:hjd]"}
{"concept_id": "C2752590", "aliases": [], "types": ["T026"], "canonical_name": "stereocilia coupling link", "definition": "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle. [PMID:16775142]"}
{"concept_id": "C2752591", "aliases": [], "types": ["T026"], "canonical_name": "stereocilia tip link", "definition": "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia. [PMID:1108787]"}
{"concept_id": "C2752592", "aliases": [], "types": ["T026"], "canonical_name": "stereocilia ankle link", "definition": "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia. [PMID:17567809]"}
{"concept_id": "C2752593", "aliases": ["stereocilia ankle link complex location"], "types": ["T026"], "canonical_name": "stereocilia ankle link complex", "definition": "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin. [PMID:16775142]"}
{"concept_id": "C2752594", "aliases": ["wobble position s2U biosynthesis", "tRNA wobble uridine thiolation"], "types": ["T045"], "canonical_name": "tRNA wobble position uridine thiolation", "definition": "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. [PMID:16871210]"}
{"concept_id": "C2752595", "aliases": ["cytosolic tRNA wobble base thiouridylase complex location"], "types": ["T026"], "canonical_name": "cytosolic tRNA wobble base thiouridylase complex", "definition": "A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets. [PMID:17062623, PMID:18391219]"}
{"concept_id": "C2752596", "aliases": ["Cut1-Cut2 complex location"], "types": ["T026"], "canonical_name": "Cut1-Cut2 complex"}
{"concept_id": "C2752597", "aliases": [], "types": ["T026"], "canonical_name": "tRNA thiouridylase"}
{"concept_id": "C2752598", "aliases": ["HMP-PP pyrophosphatase", "HMP-PP diphosphatase"], "types": ["T044"], "canonical_name": "4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity", "definition": "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+). [MetaCyc:RXN0-3543]"}
{"concept_id": "C2752601", "aliases": ["HOCl metabolic process", "hypochlorous acid metabolism", "HClO metabolic process"], "types": ["T040"], "canonical_name": "hypochlorous acid metabolic process", "definition": "The chemical reactions and pathways involving hypochlorous acid. [GOC:add, PMID:10085024, PMID:176150]"}
{"concept_id": "C2752602", "aliases": [], "types": ["T040"], "canonical_name": "hypochlorite metabolic process"}
{"concept_id": "C2752603", "aliases": ["HClO biosynthetic process", "HOCl biosynthetic process", "hypochlorous acid biosynthesis"], "types": ["T040"], "canonical_name": "hypochlorous acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hypochlorous acid. [GOC:add, PMID:10085024, PMID:176150]"}
{"concept_id": "C2752604", "aliases": [], "types": ["T040"], "canonical_name": "hypochlorite biosynthetic process"}
{"concept_id": "C2752605", "aliases": ["HOCl catabolic process", "HClO catabolic process", "hypochlorous acid catabolism"], "types": ["T040"], "canonical_name": "hypochlorous acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid. [GOC:add]"}
{"concept_id": "C2752606", "aliases": [], "types": ["T040"], "canonical_name": "hypochlorite catabolic process"}
{"concept_id": "C2752607", "aliases": ["G-quadruplex RNA binding", "G quadruplex binding", "G quartet RNA binding", "G quartet binding"], "types": ["T045"], "definition": "Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad. [PMID:18294969, PMID:18568163, PMID:19330720]", "canonical_name": "G-quartet binding"}
{"concept_id": "C2752608", "aliases": [], "types": ["T044"], "canonical_name": "bile acid conjugation", "definition": "The process in which bile acids are covalently linked to taurine or glycine. [PMID:1094911, PMID:708413]"}
{"concept_id": "C2752609", "aliases": ["SRA binding"], "types": ["T045"], "canonical_name": "steroid receptor RNA activator RNA binding", "definition": "Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding. [GOC:vw, PMID:10199399, PMID:15180993]"}
{"concept_id": "C2752610", "aliases": ["thyroid hormone mediated signalling pathway"], "types": ["T044"], "canonical_name": "thyroid hormone mediated signaling pathway", "definition": "The series of molecular signals mediated by the detection of a thyroid hormone. [GOC:hjd]"}
{"concept_id": "C2752611", "aliases": ["regulation of thyroid hormone mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of thyroid hormone mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway. [GOC:hjd]"}
{"concept_id": "C2752612", "aliases": ["negative regulation of thyroid hormone mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of thyroid hormone mediated signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway. [GOC:hjd]"}
{"concept_id": "C2752613", "aliases": ["positive regulation of thyroid hormone mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of thyroid hormone mediated signaling pathway", "definition": "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway. [GOC:hjd]"}
{"concept_id": "C2752614", "aliases": [], "types": ["T043"], "canonical_name": "osteoclast proliferation", "definition": "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. [CL:0000092, GOC:hjd]"}
{"concept_id": "C2752615", "aliases": [], "types": ["T043"], "canonical_name": "desmosome assembly", "definition": "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. [GOC:hjd, ISBN:0198506732]"}
{"concept_id": "C2752616", "aliases": [], "types": ["T043"], "canonical_name": "desmosome maintenance", "definition": "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. [GOC:hjd, ISBN:0198506732]"}
{"concept_id": "C2752617", "aliases": [], "types": ["T044"], "canonical_name": "aminoacyl-tRNA editing activity", "definition": "The hydrolysis of an incorrectly aminoacylated tRNA. [GOC:hjd, PMID:14663147, PMID:16087889]"}
{"concept_id": "C2752618", "aliases": [], "types": ["T044"], "canonical_name": "amino acid proofreading activity"}
{"concept_id": "C2752619", "aliases": [], "types": ["T044"], "canonical_name": "aminoacyl-tRNA hydrolysis activity"}
{"concept_id": "C2752620", "aliases": [], "types": ["T044"], "canonical_name": "dystroglycan binding", "definition": "Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal). [GOC:hjd]"}
{"concept_id": "C2752623", "aliases": ["VRK3/VHR/ERK complex location"], "types": ["T026"], "canonical_name": "VRK3/VHR/ERK complex", "definition": "A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway. [GOC:hjd, PMID:16845380]"}
{"concept_id": "C2752624", "aliases": ["mitochondrial MCCC complex", "methylcrotonoyl-CoA carboxylase complex", "mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme", "methylcrotonoyl-CoA carboxylase complex location", "mitochondrial methylcrotonoyl-CoA carboxylase complex", "3-methylcrotonyl-CoA carboxylase complex location, mitochondrial", "mitochondrial methylcrotonoyl-CoA carboxylase complex location", "mitochondrial MCCC complex location"], "types": ["T026"], "canonical_name": "3-methylcrotonyl-CoA carboxylase complex, mitochondrial", "definition": "A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA. [GOC:bf, GOC:hjd, PMID:15868465, PMID:17360195, PMID:22869039]"}
{"concept_id": "C2752625", "aliases": [], "types": ["T042"], "canonical_name": "establishment of body hair or bristle planar orientation", "definition": "Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project. [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C2752626", "aliases": [], "types": ["T042"], "canonical_name": "establishment of body hair planar orientation", "definition": "Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface. [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C2752627", "aliases": ["establishment of body bristle planar orientation"], "types": ["T042"], "canonical_name": "establishment of thoracic bristle planar orientation", "definition": "Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction. [FBbt:00004298, FBbt:00004408, GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C2752628", "aliases": ["COPII vesicle coating", "COPII vesicle coat assembly", "COPII vesicle coat formation"], "types": ["T043"], "definition": "The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]", "canonical_name": "COPII coating of ER-derived vesicle"}
{"concept_id": "C2752629", "aliases": [], "types": ["T038"], "canonical_name": "flower calyx development", "definition": "The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure. [GOC:go_curators]"}
{"concept_id": "C2752630", "aliases": [], "types": ["T043"], "canonical_name": "terminal differentiation"}
{"concept_id": "C2752631", "aliases": [], "types": ["T043"], "canonical_name": "functional differentiation"}
{"concept_id": "C2752632", "aliases": [], "types": ["T042"], "canonical_name": "bursa of Fabricius development", "definition": "The process whose specific outcome is the progression of the bursa of Fabricius over time, from its formation to the mature structure. The bursa of Fabricius is an organ found in birds involved in B cell differentiation. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C2752633", "aliases": [], "types": ["T043"], "canonical_name": "histamine production involved in acute inflammatory response"}
{"concept_id": "C2752634", "aliases": [], "types": ["T043"], "canonical_name": "serotonin production involved in acute inflammatory response"}
{"concept_id": "C2752635", "aliases": [], "types": ["T043"], "canonical_name": "platelet activating factor production involved in acute inflammatory response"}
{"concept_id": "C2752636", "aliases": ["lysosomal enzyme production involved in acute inflammatory response"], "types": ["T043"], "canonical_name": "production of lysosomal enzymes involved in acute inflammatory response"}
{"concept_id": "C2752637", "aliases": [], "types": ["T043"], "canonical_name": "histamine secretion involved in acute inflammatory response"}
{"concept_id": "C2752638", "aliases": [], "types": ["T043"], "canonical_name": "serotonin secretion involved in acute inflammatory response"}
{"concept_id": "C2752639", "aliases": [], "types": ["T043"], "canonical_name": "humoral defence mechanism"}
{"concept_id": "C2752640", "aliases": ["vivipary"], "types": ["T040"], "canonical_name": "vivipary"}
{"concept_id": "C2752641", "aliases": [], "types": ["T040"], "canonical_name": "skeletal muscle tissue growth", "definition": "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. [GOC:lm, PMID:15726494, PMID:15907921]"}
{"concept_id": "C2752642", "aliases": [], "types": ["T040"], "canonical_name": "regulation of skeletal muscle tissue growth", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle growth. [GOC:lm, PMID:15726494, PMID:15907921]"}
{"concept_id": "C2752643", "aliases": [], "types": ["T038"], "canonical_name": "regulation of muscle organ development", "definition": "Any process that modulates the frequency, rate or extent of muscle development. [GOC:go_curators]"}
{"concept_id": "C2752644", "aliases": [], "types": ["T038"], "canonical_name": "regulation of skeletal muscle tissue development", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. [GOC:go_curators]"}
{"concept_id": "C2752645", "aliases": [], "types": ["T042"], "canonical_name": "muscle organ morphogenesis", "definition": "The process in which the anatomical structures of muscle are generated and organized. [GOC:jid]"}
{"concept_id": "C2752646", "aliases": [], "types": ["T042"], "canonical_name": "hypodermis morphogenesis"}
{"concept_id": "C2752647", "aliases": [], "types": ["T042"], "canonical_name": "smooth muscle tissue development", "definition": "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. [GOC:dph, GOC:jid, GOC:lm]"}
{"concept_id": "C2752648", "aliases": [], "types": ["T043"], "canonical_name": "chiasma assembly", "definition": "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids. [PMID:23396135]"}
{"concept_id": "C2752649", "aliases": ["RNA polymerase II transcriptional preinitiation complex formation", "RNA polymerase II transcription PIC biosynthesis", "RNA polymerase II transcription PIC formation", "RNA polymerase II transcriptional preinitiation complex assembly"], "types": ["T044"], "canonical_name": "RNA polymerase II preinitiation complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. [GOC:txnOH, PMID:10882737, PMID:15020047]"}
{"concept_id": "C2752652", "aliases": [], "types": ["T026"], "canonical_name": "regulation of focal adhesion assembly", "definition": "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. [GOC:ai]"}
{"concept_id": "C2752657", "aliases": [], "types": ["T038"], "canonical_name": "production of molecular mediator involved in acute inflammatory response"}
{"concept_id": "C2752658", "aliases": ["lysosomal enzyme secretion involved in acute inflammatory response"], "types": ["T043"], "canonical_name": "secretion of lysosomal enzymes involved in acute inflammatory response"}
{"concept_id": "C2752659", "aliases": [], "types": ["T040"], "canonical_name": "cytokine production involved in acute inflammatory response"}
{"concept_id": "C2752661", "aliases": ["nitric oxide production involved in acute inflammatory response"], "types": ["T039"], "canonical_name": "production of nitric oxide involved in acute inflammatory response"}
{"concept_id": "C2752662", "aliases": ["arachidonic acid metabolite production involved in acute inflammatory response"], "types": ["T039"], "canonical_name": "production of arachidonic acid metabolites involved in acute inflammatory response"}
{"concept_id": "C2752663", "aliases": [], "types": ["T039"], "canonical_name": "prostaglandin production involved in acute inflammatory response"}
{"concept_id": "C2752664", "aliases": [], "types": ["T039"], "canonical_name": "leukotriene production involved in acute inflammatory response"}
{"concept_id": "C2752665", "aliases": [], "types": ["T044"], "canonical_name": "activation of plasma proteins involved in acute inflammatory response", "definition": "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response. [GOC:jal, ISBN:0781735149]"}
{"concept_id": "C2752666", "aliases": [], "types": ["T042"], "canonical_name": "myocardium morphogenesis"}
{"concept_id": "C2752667", "aliases": ["Nic96 complex location"], "types": ["T026"], "canonical_name": "Nic96 complex", "definition": "OBSOLETE. A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p. [GOC:jh, PMID:12791264, PMID:15741174]"}
{"concept_id": "C2752668", "aliases": ["Nup82 complex location"], "types": ["T026"], "canonical_name": "Nup82 complex", "definition": "OBSOLETE. A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p. [GOC:jh, PMID:12791264, PMID:15741174]"}
{"concept_id": "C2752669", "aliases": [], "types": ["T038"], "canonical_name": "vibrational conductance of sound to the inner ear", "definition": "The transmission of vibrations via ossicles to the inner ear. [GOC:mh]"}
{"concept_id": "C2752670", "aliases": [], "types": ["T044"], "canonical_name": "L-proline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. [GOC:ecd]"}
{"concept_id": "C2752671", "aliases": ["(2R)-2-aminopropanoic acid catabolic process"], "types": ["T044"], "canonical_name": "D-alanine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine. [GOC:ecd]"}
{"concept_id": "C2752672", "aliases": [], "types": ["T044"], "canonical_name": "C3HC4-type RING finger domain binding", "definition": "Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway. [GOC:amm, InterPro:IPR001841, InterPro:IPR018957]"}
{"concept_id": "C2752673", "aliases": ["hemolymph circulation"], "types": ["T042"], "canonical_name": "hemolymph circulation"}
{"concept_id": "C2752675", "aliases": [], "types": ["T044"], "canonical_name": "regulation of signal transduction involved in conjugation with cellular fusion", "definition": "Any process that modulates the rate, frequency or extent of pheromone-dependent signal transduction during conjugation with cellular fusion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752676", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of signal transduction involved in conjugation with cellular fusion", "definition": "Any process that increases the rate, frequency or extent of signal transduction involved in conjugation with cellular fusion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752677", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of signal transduction involved in conjugation with cellular fusion", "definition": "Any process that decreases the rate, frequency or extent of the series signal transduction involved in conjugation with cellular fusion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752678", "aliases": [], "types": ["T039"], "canonical_name": "regulation of respiratory burst involved in acute inflammatory response"}
{"concept_id": "C2752679", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of respiratory burst involved in acute inflammatory response"}
{"concept_id": "C2752680", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of respiratory burst involved in acute inflammatory response"}
{"concept_id": "C2752682", "aliases": [], "types": ["T043"], "canonical_name": "cilium movement involved in cell motility", "definition": "Movement of cilia mediated by motor proteins that contributes to the movement of a cell. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752683", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cilium movement involved in cell motility", "definition": "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752684", "aliases": ["regulation of phosphoinositide dephosphorylation"], "types": ["T043"], "canonical_name": "regulation of phosphatidylinositol dephosphorylation", "definition": "Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752685", "aliases": [], "types": ["T040"], "canonical_name": "sagittal suture morphogenesis", "definition": "The process in which the sagittal suture is generated and organized. [GOC:dph, GOC:sl]"}
{"concept_id": "C2752686", "aliases": ["resumption of meiosis involved in egg activation"], "types": ["T043"], "canonical_name": "activation of meiosis involved in egg activation", "definition": "Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation. [GOC:dph]"}
{"concept_id": "C2752687", "aliases": [], "types": ["T043"], "canonical_name": "reactivation of meiosis after fertilization"}
{"concept_id": "C2752688", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of fertilization", "definition": "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). [GOC:dph]"}
{"concept_id": "C2752689", "aliases": ["polyspermy block", "negative regulation of fertilization involved in egg activation"], "types": ["T038"], "canonical_name": "prevention of polyspermy", "definition": "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. [GOC:dph]"}
{"concept_id": "C2752693", "aliases": ["elevation of cytosolic calcium ion concentration involved in egg activation"], "types": ["T044"], "canonical_name": "positive regulation of cytosolic calcium ion concentration involved in egg activation", "definition": "The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg. [GOC:dph]"}
{"concept_id": "C2752694", "aliases": ["cortical granule release"], "types": ["T043"], "canonical_name": "cortical granule exocytosis", "definition": "The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy. [GOC:dph]"}
{"concept_id": "C2752695", "aliases": ["positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration"], "types": ["T043"], "canonical_name": "positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration", "definition": "Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol. [GOC:dph]"}
{"concept_id": "C2752696", "aliases": [], "types": ["T026"], "canonical_name": "cortical granule", "definition": "A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy. [GOC:dph]"}
{"concept_id": "C2752697", "aliases": [], "types": ["T026"], "canonical_name": "cortical vesicle"}
{"concept_id": "C2752698", "aliases": [], "types": ["T055"], "canonical_name": "positive regulation of sperm motility involved in capacitation"}
{"concept_id": "C2752699", "aliases": ["positive regulation of actin polymerization involved in acrosome reaction"], "types": ["T043"], "canonical_name": "positive regulation of actin filament polymerization involved in acrosome reaction", "definition": "Any process that activates or increases the frequency, rate or extent of actin polymerization as part of the acrosome reaction. [GOC:dph]"}
{"concept_id": "C2752700", "aliases": ["protein localisation involved in acrosome reaction"], "types": ["T043"], "canonical_name": "protein localization involved in acrosome reaction", "definition": "The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction. [GOC:dph]"}
{"concept_id": "C2752702", "aliases": ["acrosome exocytosis", "acrosomal granule exocytosis"], "types": ["T043"], "canonical_name": "acrosomal vesicle exocytosis", "definition": "The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction. [GOC:dph]"}
{"concept_id": "C2752703", "aliases": ["pulmonary cell differentiation"], "types": ["T043"], "canonical_name": "lung cell differentiation", "definition": "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752704", "aliases": ["pulmonary goblet cell differentiation"], "types": ["T043"], "canonical_name": "lung goblet cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752705", "aliases": [], "types": ["T042"], "canonical_name": "lobar bronchus epithelium development", "definition": "The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752706", "aliases": [], "types": ["T038"], "canonical_name": "lobar bronchus development", "definition": "The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752707", "aliases": [], "types": ["T042"], "canonical_name": "lobar bronchus mesenchyme development", "definition": "The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752708", "aliases": ["lung mesenchyme development", "pulmonary mesenchyme development"], "types": ["T042"], "canonical_name": "lung-associated mesenchyme development", "definition": "The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752709", "aliases": ["mesenchymal development"], "types": ["T042"], "canonical_name": "mesenchyme development", "definition": "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. [GOC:dph]"}
{"concept_id": "C2752710", "aliases": ["club cell differentiation"], "types": ["T043"], "definition": "The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles. [GOC:dph, GOC:mtg_lung, PMID:28144783]", "canonical_name": "Clara cell differentiation"}
{"concept_id": "C2752711", "aliases": ["pulmonary epithelial cell differentiation"], "types": ["T043"], "canonical_name": "lung epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. [GOC:dph]"}
{"concept_id": "C2752712", "aliases": ["perpendicular dichotomous subdivision of terminal units involved in lung branching morphogenesis"], "types": ["T042"], "canonical_name": "orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis", "definition": "The process in which a lung bud bifurcates perpendicular to the plane of the previous bud. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752713", "aliases": [], "types": ["T042"], "canonical_name": "planar dichotomous subdivision of terminal units involved in lung branching morphogenesis", "definition": "The process in which a lung bud bifurcates parallel to the plane of the previous bud. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752714", "aliases": [], "types": ["T042"], "canonical_name": "lateral sprouting involved in lung morphogenesis", "definition": "The process in which a branch forms along the side of the lung epithelial tube. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752715", "aliases": ["regulation of cell projection formation"], "types": ["T043"], "canonical_name": "regulation of cell projection assembly", "definition": "Any process that modulates the rate, frequency, or extent of cell projection assembly. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752716", "aliases": [], "types": ["T042"], "canonical_name": "lung induction", "definition": "The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung. [GOC:dph]"}
{"concept_id": "C2752717", "aliases": ["mesenchymal-endodermal cell signalling involved in lung induction"], "types": ["T043"], "canonical_name": "mesenchymal-endodermal cell signaling involved in lung induction", "definition": "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell in the foregut and contributes to the formation of the lung bud. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752718", "aliases": ["inductive mesenchymal-endodermal cell signalling"], "types": ["T043"], "canonical_name": "inductive mesenchymal-endodermal cell signaling", "definition": "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell changing the fate of the endodermal cell. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752719", "aliases": ["cell-cell signalling involved in lung development"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in lung development", "definition": "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752720", "aliases": ["mesenchymal-epithelial cell signalling involved in lung development"], "types": ["T043"], "canonical_name": "mesenchymal-epithelial cell signaling involved in lung development", "definition": "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752721", "aliases": ["mesenchymal-endodermal cell signalling"], "types": ["T043"], "canonical_name": "mesenchymal-endodermal cell signaling", "definition": "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell. [GOC:dph]"}
{"concept_id": "C2752722", "aliases": ["retinoic acid receptor signalling pathway involved in lung bud formation"], "types": ["T044"], "canonical_name": "retinoic acid receptor signaling pathway involved in lung bud formation", "definition": "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands contributing to the formation of the primary lung bud. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752723", "aliases": ["fibroblast growth factor receptor signalling pathway involved in lung induction"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in lung induction", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands resulting in the formation of the lung bud along the lateral-esophageal sulcus. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752725", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of epithelial cell proliferation involved in lung morphogenesis", "definition": "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. [GOC:dph]"}
{"concept_id": "C2752726", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell proliferation involved in lung morphogenesis", "definition": "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. [GOC:dph]"}
{"concept_id": "C2752727", "aliases": ["bud expansion"], "types": ["T040"], "canonical_name": "bud dilation involved in lung branching", "definition": "The process in which a bud in the lung increases radially. [GOC:dph]"}
{"concept_id": "C2752728", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of epithelial cell proliferation involved in lung bud dilation", "definition": "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially. [GOC:dph]"}
{"concept_id": "C2752729", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell proliferation involved in lung bud dilation", "definition": "The multiplication or reproduction of epithelial cells that contribute to the radial growth of a lung bud. [GOC:dph]"}
{"concept_id": "C2752730", "aliases": ["hh signaling pathway involved in lung development", "hedgehog signaling pathway involved in lung development", "smoothened signalling pathway involved in lung development"], "types": ["T044"], "canonical_name": "smoothened signaling pathway involved in lung development", "definition": "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752731", "aliases": ["epidermal growth factor receptor signalling pathway involved in lung development"], "types": ["T044"], "canonical_name": "epidermal growth factor receptor signaling pathway involved in lung development", "definition": "The series of molecular signals generated as a consequence of an epidermal growth factor-type receptor binding to one of its physiological ligands. This process contributes to lung development. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752732", "aliases": ["pulmonary basal cell differentiation"], "types": ["T043"], "canonical_name": "lung basal cell differentiation", "definition": "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752733", "aliases": ["membranous pneumocyte differentiation"], "types": ["T043"], "canonical_name": "type I pneumocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. [GOC:dph, GOC:mtg_lung, ISBN:0721662544]"}
{"concept_id": "C2752734", "aliases": [], "types": ["T043"], "canonical_name": "small alveolar cell differentiation"}
{"concept_id": "C2752735", "aliases": [], "types": ["T043"], "canonical_name": "squamous alveolar cell differentiation"}
{"concept_id": "C2752736", "aliases": ["great alveolar cell differentiation"], "types": ["T043"], "canonical_name": "type II pneumocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies. [GOC:dph, GOC:mtg_lung, ISBN:0721662544]"}
{"concept_id": "C2752737", "aliases": [], "types": ["T043"], "canonical_name": "granular pneumocyte differentiation"}
{"concept_id": "C2752738", "aliases": [], "types": ["T043"], "canonical_name": "large alveolar cell differentiation"}
{"concept_id": "C2752739", "aliases": [], "types": ["T043"], "canonical_name": "creation of an inductive signal by a mesenchymal cell involved in lung induction", "definition": "The process in which splanchnic mesenchymal cells send a signal over a short range to endodermal cells inducing them to form the primary lung bud. [GOC:dph, GOC:mtg_lung]"}
{"concept_id": "C2752740", "aliases": [], "types": ["T039"], "canonical_name": "prostate gland morphogenesis", "definition": "The process in which the anatomical structures of a prostate gland are generated and organized. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752741", "aliases": ["primary prostate bud formation", "prostate ductal budding", "prostate gland formation"], "types": ["T042"], "canonical_name": "prostatic bud formation", "definition": "The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752742", "aliases": [], "types": ["T042"], "canonical_name": "prostate induction", "definition": "The close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752743", "aliases": [], "types": ["T039"], "canonical_name": "prostate field specification", "definition": "The process that results in the delineation of a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752744", "aliases": ["prostate bud elongation", "prostate bud elongation involved in prostate morphogenesis"], "types": ["T042"], "canonical_name": "primary prostatic bud elongation", "definition": "The increase in size of the prostatic bud as it forms. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752745", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell proliferation involved in prostatic bud elongation", "definition": "The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752746", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in prostatic bud elongation", "definition": "The orderly movement of epithelial cells from one site to another contributing to the elongation of the primary prostatic bud. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752747", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in prostatic bud elongation", "definition": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the elongation of the primary prostatic bud. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752748", "aliases": ["activation of prostate induction by androgen receptor signalling pathway"], "types": ["T043"], "canonical_name": "activation of prostate induction by androgen receptor signaling pathway", "definition": "The series of molecular signals initiated by androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland. [GOC:dph, GOC:tb, PMID:18977204]"}
{"concept_id": "C2752749", "aliases": ["mesenchymal-epithelial cell signalling involved in prostate induction"], "types": ["T043"], "canonical_name": "mesenchymal-epithelial cell signaling involved in prostate induction", "definition": "Signaling at short range from urogenital sinus mesenchymal cells to cells of the urogenital epithelium resulting in the epithelial cells adopting a prostatic fate. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752750", "aliases": ["inductive mesenchymal to epithelial cell signalling"], "types": ["T043"], "canonical_name": "inductive mesenchymal to epithelial cell signaling", "definition": "Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells. [GOC:dph]"}
{"concept_id": "C2752751", "aliases": [], "types": ["T042"], "canonical_name": "prostate epithelial cord elongation", "definition": "The developmental growth process in which solid chords of prostate epithelium increase in length. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752752", "aliases": ["prostate epithelial cord bifurcation"], "types": ["T039"], "canonical_name": "dichotomous subdivision of prostate epithelial cord terminal unit", "definition": "The process in which a prostate epithelial cord bifurcates at its end. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752753", "aliases": ["prostate glandular acinus morphogenesis"], "types": ["T043"], "canonical_name": "prostate glandular acinus development", "definition": "The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland. [GOC:dph]"}
{"concept_id": "C2752754", "aliases": [], "types": ["T040"], "canonical_name": "prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis", "definition": "The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752755", "aliases": [], "types": ["T043"], "canonical_name": "secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development", "definition": "The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752756", "aliases": [], "types": ["T043"], "canonical_name": "squamous basal epithelial stem cell differentiation involved in prostate gland acinus development", "definition": "The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752757", "aliases": [], "types": ["T039"], "canonical_name": "smooth muscle cell differentiation involved in prostate glandular acinus development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752758", "aliases": [], "types": ["T039"], "canonical_name": "neuroendocrine cell differentiation involved in prostate gland acinus development", "definition": "The process in which relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus. [GOC:dph, PMID:18977204]"}
{"concept_id": "C2752759", "aliases": ["bronchus cartilage morphogenesis", "pulmonary cartilage development"], "types": ["T042"], "canonical_name": "bronchus cartilage development", "definition": "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs. [GOC:dph]"}
{"concept_id": "C2752760", "aliases": ["trachea cartilage morphogenesis"], "types": ["T042"], "canonical_name": "trachea cartilage development", "definition": "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]"}
{"concept_id": "C2752761", "aliases": [], "types": ["T042"], "canonical_name": "cartilage morphogenesis", "definition": "The process in which the anatomical structures of cartilage are generated and organized. [GOC:dph]"}
{"concept_id": "C2752762", "aliases": [], "types": ["T042"], "canonical_name": "muscle tissue development", "definition": "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. [GOC:dph]"}
{"concept_id": "C2752763", "aliases": [], "types": ["T042"], "canonical_name": "skeletal muscle organ development", "definition": "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. [GOC:dph]"}
{"concept_id": "C2752764", "aliases": ["diaphragm morphogenesis"], "types": ["T042"], "canonical_name": "diaphragm development", "definition": "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. [GOC:dph]"}
{"concept_id": "C2752765", "aliases": [], "types": ["T040"], "canonical_name": "respiratory system development", "definition": "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. [GOC:dph]"}
{"concept_id": "C2752766", "aliases": [], "types": ["T043"], "canonical_name": "regulation of strand invasion", "definition": "Any process that modulates the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752767", "aliases": ["negative regulation of Rad51-mediated strand invasion"], "types": ["T043"], "canonical_name": "negative regulation of strand invasion", "definition": "Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. [GOC:dph, GOC:elh, GOC:tb]"}
{"concept_id": "C2752768", "aliases": ["negative regulation of D-loop formation"], "types": ["T043"], "canonical_name": "negative regulation of D-loop biosynthesis"}
{"concept_id": "C2752769", "aliases": ["regulation of necroptosis"], "types": ["T043"], "canonical_name": "regulation of necroptotic process", "definition": "Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2752770", "aliases": ["positive regulation of necroptosis"], "types": ["T043"], "canonical_name": "positive regulation of necroptotic process", "definition": "Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2752772", "aliases": [], "types": ["T044"], "canonical_name": "regulation of fructose 1,6-bisphosphate 1-phosphatase activity", "definition": "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752773", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity", "definition": "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752774", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fructose 1,6-bisphosphate metabolic process", "definition": "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752775", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of fructose 1,6-bisphosphate metabolic process", "definition": "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752776", "aliases": ["establishment of necroptosis", "induction of necroptosis"], "types": ["T043"], "canonical_name": "activation of necroptosis"}
{"concept_id": "C2752777", "aliases": [], "types": ["T043"], "canonical_name": "induction of necroptosis of activated-T cells"}
{"concept_id": "C2752778", "aliases": [], "types": ["T043"], "canonical_name": "induction of necroptosis by extracellular signals"}
{"concept_id": "C2752779", "aliases": [], "types": ["T044"], "canonical_name": "regulation of vitamin D biosynthetic process", "definition": "Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309]"}
{"concept_id": "C2752780", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of vitamin D biosynthetic process", "definition": "Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309]"}
{"concept_id": "C2752781", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcidiol 1-monooxygenase activity", "definition": "Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752782", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of calcidiol 1-monooxygenase activity", "definition": "Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752783", "aliases": ["differential growth"], "types": ["T040"], "canonical_name": "developmental growth involved in morphogenesis", "definition": "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. [GOC:dph]"}
{"concept_id": "C2752784", "aliases": [], "types": ["T043"], "canonical_name": "morphogenetic apoptosis"}
{"concept_id": "C2752785", "aliases": [], "types": ["T042"], "canonical_name": "epithelial tube morphogenesis", "definition": "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. [GOC:dph]"}
{"concept_id": "C2752786", "aliases": [], "types": ["T043"], "canonical_name": "neuroepithelial cell differentiation", "definition": "The process in which epiblast cells acquire specialized features of neuroepithelial cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752787", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of APC activity during mitotic cell cycle"}
{"concept_id": "C2752790", "aliases": ["positive regulation of transcription termination, DNA-dependent", "positive regulation of DNA-dependent transcription, termination", "positive regulation of termination of DNA-dependent transcription"], "types": ["T045"], "canonical_name": "positive regulation of DNA-templated transcription, termination", "definition": "Any process that increases the rate, frequency or extent of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2752791", "aliases": ["negative regulation of termination of DNA-dependent transcription", "negative regulation of transcription termination, DNA-dependent", "negative regulation of DNA-dependent transcription, termination"], "types": ["T045"], "canonical_name": "negative regulation of DNA-templated transcription, termination", "definition": "Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2752792", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peptide hormone processing", "definition": "Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752793", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of peptide hormone processing", "definition": "Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752794", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of peptide hormone processing", "definition": "Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752795", "aliases": ["folding of an epithelial sheet", "epithelial folding"], "types": ["T042"], "canonical_name": "morphogenesis of an epithelial fold", "definition": "The morphogenetic process in which an epithelial sheet bends along a linear axis. [GOC:dph]"}
{"concept_id": "C2752796", "aliases": [], "types": ["T042"], "canonical_name": "morphogenesis of an epithelial bud", "definition": "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. [GOC:dph]"}
{"concept_id": "C2752797", "aliases": [], "types": ["T043"], "canonical_name": "cell fate specification involved in pattern specification", "definition": "The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752798", "aliases": [], "types": ["T043"], "canonical_name": "intestinal epithelial cell maturation", "definition": "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. [GOC:dph, PMID:18824147]"}
{"concept_id": "C2752799", "aliases": [], "types": ["T043"], "canonical_name": "intestinal epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. [GOC:dph]"}
{"concept_id": "C2752800", "aliases": [], "types": ["T043"], "canonical_name": "intestinal epithelial cell development", "definition": "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C2752801", "aliases": ["pulmonary venous blood vessel morphogenesis"], "types": ["T042"], "canonical_name": "pulmonary vein morphogenesis", "definition": "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. [GOC:dph]"}
{"concept_id": "C2752802", "aliases": [], "types": ["T042"], "canonical_name": "superior vena cava morphogenesis", "definition": "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. [GOC:dph]"}
{"concept_id": "C2752803", "aliases": [], "types": ["T043"], "canonical_name": "ventral spinal cord interneuron fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. [GOC:dph]"}
{"concept_id": "C2752804", "aliases": [], "types": ["T043"], "canonical_name": "ventral spinal cord interneuron fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. [GOC:dph]"}
{"concept_id": "C2752805", "aliases": [], "types": ["T043"], "canonical_name": "cell fate commitment involved in pattern specification", "definition": "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. [GOC:dph]"}
{"concept_id": "C2752806", "aliases": [], "types": ["T043"], "canonical_name": "cell fate determination involved in pattern specification", "definition": "A process involved in commitment of a cell to a fate in a developmental field. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. [GOC:dph]"}
{"concept_id": "C2752807", "aliases": ["regulation of actin cortical patch localisation"], "types": ["T039"], "canonical_name": "regulation of actin cortical patch localization", "definition": "Any process that modulates the localization of an actin cortical patch. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752808", "aliases": ["regulation of (PG)H synthase activity", "regulation of fatty acid cyclooxygenase activity", "regulation of PG synthetase activity", "regulation of prostaglandin synthetase activity"], "types": ["T044"], "canonical_name": "regulation of prostaglandin-endoperoxide synthase activity", "definition": "Any process that modulates the rate, frequency or prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752809", "aliases": ["positive regulation of prostaglandin synthetase activity", "positive regulation of fatty acid cyclooxygenase activity", "positive regulation of PG synthetase activity", "positive regulation of (PG)H synthase activity"], "types": ["T044"], "canonical_name": "positive regulation of prostaglandin-endoperoxide synthase activity", "definition": "Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752810", "aliases": [], "types": ["T038"], "canonical_name": "multicellular organismal iron ion homeostasis", "definition": "Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism. [GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2752811", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lipoprotein lipid oxidation", "definition": "Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752812", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lipoprotein lipid oxidation", "definition": "Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752813", "aliases": ["NTPase regulator activity"], "types": ["T044"], "canonical_name": "nucleoside-triphosphatase regulator activity", "definition": "Binds to and modulates the activity of an NTPase. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752814", "aliases": ["ATP hydrolysis regulator activity"], "types": ["T044"], "canonical_name": "ATPase regulator activity", "definition": "Binds to and modulates the activity of an ATP hydrolysis activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752815", "aliases": ["chondrocyte progenitor cell differentiation"], "types": ["T043"], "canonical_name": "chondroblast differentiation", "definition": "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. [GOC:dph]"}
{"concept_id": "C2752816", "aliases": [], "types": ["T042"], "canonical_name": "mammary gland formation", "definition": "The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme. [GOC:dph, PMID:16168142, PMID:17120154]"}
{"concept_id": "C2752817", "aliases": [], "types": ["T042"], "canonical_name": "mammary bud formation"}
{"concept_id": "C2752818", "aliases": [], "types": ["T042"], "canonical_name": "mammary line formation"}
{"concept_id": "C2752819", "aliases": ["mammary placode formation"], "types": ["T042"], "canonical_name": "mammary placode formation", "definition": "The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper. [GOC:dph, PMID:16168142]"}
{"concept_id": "C2752820", "aliases": [], "types": ["T042"], "canonical_name": "mammary sprout formation"}
{"concept_id": "C2752821", "aliases": ["Wnt receptor signalling pathway involved in mammary gland specification", "Wnt receptor signaling pathway involved in mammary gland specification", "Wnt-activated signaling pathway involved in mammary gland specification"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in mammary gland specification", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes. [GOC:dph, PMID:16168142]"}
{"concept_id": "C2752822", "aliases": ["mammary line specification"], "types": ["T042"], "canonical_name": "mammary gland specification", "definition": "The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes. [GOC:dph]"}
{"concept_id": "C2752823", "aliases": ["fibroblast growth factor receptor signalling pathway involved in mammary gland specification"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in mammary gland specification", "definition": "The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes. [GOC:dph, PMID:16168142]"}
{"concept_id": "C2752825", "aliases": ["primary mammary duct branching"], "types": ["T042"], "canonical_name": "dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis", "definition": "The process in which the terminal end of a mammary duct bifurcates. [GOC:dph, PMID:17120154]"}
{"concept_id": "C2752826", "aliases": ["mammary gland duct secondary branching"], "types": ["T042"], "canonical_name": "lateral sprouting involved in mammary gland duct morphogenesis", "definition": "The process in which a branch forms along the side of a mammary duct. [GOC:dph, PMID:17120154]"}
{"concept_id": "C2752827", "aliases": [], "types": ["T042"], "canonical_name": "dichotomous subdivision of an epithelial terminal unit", "definition": "The process in which an epithelial cord, rod or tube bifurcates at its end. [GOC:dph]"}
{"concept_id": "C2752828", "aliases": [], "types": ["T042"], "canonical_name": "primary branching of an epithelium"}
{"concept_id": "C2752829", "aliases": [], "types": ["T042"], "canonical_name": "lateral sprouting from an epithelium", "definition": "The process in which a branch forms along the side of an epithelium. [GOC:dph]"}
{"concept_id": "C2752830", "aliases": [], "types": ["T040"], "canonical_name": "branch elongation of an epithelium", "definition": "The growth process in which a branch increases in length from its base to its tip. [GOC:dph]"}
{"concept_id": "C2752831", "aliases": [], "types": ["T042"], "canonical_name": "mammary gland duct morphogenesis", "definition": "The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. [GOC:dph, PMID:17120154]"}
{"concept_id": "C2752832", "aliases": ["milk duct cavitation"], "types": ["T042"], "canonical_name": "mammary gland duct cavitation", "definition": "Creation of the central hole of the mammary gland duct by the hollowing out of a solid rod. [GOC:dph, PMID:17120154]"}
{"concept_id": "C2752833", "aliases": [], "types": ["T042"], "canonical_name": "tube lumen cavitation", "definition": "The formation of a lumen by hollowing out a solid rod or cord. [GOC:dph]"}
{"concept_id": "C2752834", "aliases": [], "types": ["T042"], "canonical_name": "tube closure", "definition": "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold. [GOC:dph]"}
{"concept_id": "C2752835", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in sealing an epithelial fold", "definition": "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of an epithelial tube. [GOC:dph]"}
{"concept_id": "C2752836", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in neural tube closure", "definition": "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of the neural tube. [GOC:dph]"}
{"concept_id": "C2752837", "aliases": ["apoptosis involved in tube lumen cavitation"], "types": ["T043"], "canonical_name": "apoptotic process involved in tube lumen cavitation", "definition": "Any apoptotic process that contributes to the hollowing out of an epithelial rod or cord to form the central hole in a tube. [GOC:dph, GOC:mtg_apoptosis]"}
{"concept_id": "C2752838", "aliases": ["mammary gland mesenchymal cell differentiation"], "types": ["T043"], "canonical_name": "mesenchymal cell differentiation involved in mammary gland development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mammary gland mesenchymal cell. Mammary gland mesenchymal cells form a loosely connected network of cells that surround the mammary ducts. [GOC:dph]"}
{"concept_id": "C2752839", "aliases": [], "types": ["T042"], "canonical_name": "mammary gland fat development", "definition": "The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts. [GOC:dph]"}
{"concept_id": "C2752840", "aliases": [], "types": ["T042"], "canonical_name": "fat pad development", "definition": "The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue. [GOC:dph]"}
{"concept_id": "C2752841", "aliases": ["negative regulation of mammary gland development in males by androgen receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of mammary gland development in males by androgen receptor signaling pathway", "definition": "Any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell. [GOC:dph]"}
{"concept_id": "C2752842", "aliases": [], "types": ["T042"], "canonical_name": "mammary gland bud formation", "definition": "The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752843", "aliases": ["mammary gland sprout formation"], "types": ["T042"], "canonical_name": "mammary gland cord formation", "definition": "The process in which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752844", "aliases": ["positive regulation of mammary placode formation by mesenchymal-epithelial signalling"], "types": ["T038"], "canonical_name": "positive regulation of mammary placode formation by mesenchymal-epithelial signaling", "definition": "Any process that initiates the formation of a mammary placode through a mechanism that mediates the transfer of information from a mesenchymal cell to an epithelial cell resulting in the epithelial cell adopting the identity of a cell of the mammary placode. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752845", "aliases": [], "types": ["T042"], "canonical_name": "nipple development", "definition": "The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm. [GOC:dph]"}
{"concept_id": "C2752846", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in mammary placode formation", "definition": "The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752847", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cholesterol import", "definition": "Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752848", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cholesterol import", "definition": "Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752849", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ascospore wall beta-glucan biosynthetic process", "definition": "Any process that modulates the rate, frequency or extent of ascospore wall beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752850", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chromosome condensation", "definition": "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752851", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ascospore wall 1,3-beta-glucan biosynthetic process"}
{"concept_id": "C2752852", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein deneddylation", "definition": "Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752853", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cullin deneddylation"}
{"concept_id": "C2752854", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vesicle-mediated transport", "definition": "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752855", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ER to Golgi vesicle-mediated transport", "definition": "Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752856", "aliases": [], "types": ["T045"], "canonical_name": "regulation of homologous chromosome segregation", "definition": "Any process that modulates the rate, frequency, or extent of homologous chromosome segregation, the cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752858", "aliases": [], "types": ["T043"], "canonical_name": "regulation of meiosis I", "definition": "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752859", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microtubule-based movement", "definition": "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752860", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of transcription initiation from RNA polymerase II promoter", "definition": "Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2752861", "aliases": [], "types": ["T043"], "canonical_name": "regulation of 4,6-pyruvylated galactose residue biosynthetic process", "definition": "Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-(1->3)-. The galactose residue is part of a larger polysaccharide chain. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752864", "aliases": ["positive regulation of lactation by mesenchymal-epithelial cell signalling"], "types": ["T038"], "canonical_name": "positive regulation of lactation by mesenchymal-epithelial cell signaling", "definition": "The process that increases the rate, frequency, or extent of lactation as a result of the secretion of a signal from the mammary fat and its reception by a mammary epithelial cell. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752865", "aliases": ["mesenchymal-epithelial cell signaling"], "types": ["T043"], "definition": "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted. [GOC:dph]", "canonical_name": "mesenchymal-epithelial cell signalling"}
{"concept_id": "C2752866", "aliases": ["positive regulation of salivary gland formation by mesenchymal-epithelial signalling"], "types": ["T043"], "canonical_name": "positive regulation of salivary gland formation by mesenchymal-epithelial signaling", "definition": "Any process that induces the formation of the salivary gland field by means of the secretion of a signal by a mesenchymal cell and its reception and interpretation by an epithelial cell resulting in it adopting the identity of a salivary gland bud cell. [GOC:dph]"}
{"concept_id": "C2752867", "aliases": ["positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signalling", "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signaling"], "types": ["T042"], "canonical_name": "positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling", "definition": "Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud. [GOC:dph]"}
{"concept_id": "C2752868", "aliases": [], "types": ["T042"], "canonical_name": "mammary gland duct regression in males", "definition": "The process in which the epithelium of the mammary duct is destroyed in males. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752869", "aliases": [], "types": ["T043"], "canonical_name": "white fat cell differentiation involved in mammary gland fat development", "definition": "The process in which a preadipocyte acquires specialized features of a white adipocyte of the mammary gland. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752870", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell differentiation involved in mammary gland bud morphogenesis", "definition": "The process in which a cell of the mammary placode becomes a cell of the mammary gland bud. [GOC:dph]"}
{"concept_id": "C2752871", "aliases": [], "types": ["T043"], "canonical_name": "mammary gland epithelial cell differentiation", "definition": "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. [GOC:dph]"}
{"concept_id": "C2752872", "aliases": [], "types": ["T043"], "canonical_name": "peripheral mammary gland bud epithelial cell differentiation", "definition": "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an epithelial cell at the periphery of the mammary gland bud. Cells at the periphery of the bud are larger that those of the surrounding epithelium and are arranged concentrically. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752873", "aliases": [], "types": ["T043"], "canonical_name": "internal mammary gland bud epithelial cell differentiation", "definition": "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752874", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell condensation involved in mammary fat development", "definition": "The cell adhesion process in which mammary mesenchyme cells adhere to one another in the initial stages of the formation of mammary fat development. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752875", "aliases": [], "types": ["T042"], "canonical_name": "mammary gland bud morphogenesis", "definition": "The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752876", "aliases": [], "types": ["T040"], "canonical_name": "mammary gland bud elongation", "definition": "The process in which the mammary gland bud grows along its axis. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752877", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell proliferation involved in mammary gland bud elongation", "definition": "The multiplication or reproduction of mammary gland bud epithelial cells, resulting in the elongation of the bud. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752878", "aliases": [], "types": ["T038"], "canonical_name": "regulation of epithelial cell proliferation involved in mammary gland bud elongation", "definition": "Any process that modulates the frequency, rate or extent of mammary gland bud epithelial cell proliferation that results in the elongation of the bud. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752879", "aliases": ["mammary gland sprout morphogenesis"], "types": ["T042"], "canonical_name": "mammary gland cord morphogenesis", "definition": "The process in which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752880", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell differentiation involved in mammary gland cord morphogenesis", "definition": "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752881", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell differentiation involved in mammary gland sprout morphogenesis"}
{"concept_id": "C2752882", "aliases": [], "types": ["T040"], "canonical_name": "mammary gland cord elongation", "definition": "The process in which the mammary gland sprout grows along its axis. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752883", "aliases": [], "types": ["T040"], "canonical_name": "branching involved in mammary gland cord morphogenesis", "definition": "The process in which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752884", "aliases": ["regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signalling"], "types": ["T043"], "canonical_name": "regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling", "definition": "Any process that modulates the rate, frequency, or extent of branching of the mammary gland cord as a result of a signal being created by a mammary fat precursor cell and its subsequent reception and interpretation by a mammary cord epithelial cell. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752885", "aliases": ["regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signalling"], "types": ["T043"], "canonical_name": "regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling", "definition": "Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752886", "aliases": [], "types": ["T040"], "canonical_name": "nipple morphogenesis", "definition": "The process in which the nipple is generated and organized. [GOC:dph]"}
{"concept_id": "C2752887", "aliases": [], "types": ["T042"], "canonical_name": "nipple sheath formation", "definition": "The developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis. This process begins with a circular ingrowth of the epidermis around the region of the mammary sprout. It ends before the region begins to elevate. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752888", "aliases": [], "types": ["T042"], "canonical_name": "epidermis morphogenesis involved in nipple formation", "definition": "The process in which the epidermis of the nipple sheath is uplifted to form an umbrella-like projection. [GOC:dph, PMID:12558599]"}
{"concept_id": "C2752889", "aliases": [], "types": ["T042"], "canonical_name": "submandibular salivary gland formation", "definition": "The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed. [GOC:dph, PMID:17336109]"}
{"concept_id": "C2752890", "aliases": ["salivary gland invagination"], "types": ["T042"], "canonical_name": "salivary gland cavitation", "definition": "The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland. [GOC:dph]"}
{"concept_id": "C2752891", "aliases": ["apoptosis involved in salivary gland cavitation"], "types": ["T043"], "canonical_name": "apoptotic process involved in salivary gland cavitation", "definition": "Any apoptotic process in which the solid core of the gland is hollowed out to form the duct. [GOC:dph, GOC:mtg_apoptosis, PMID:17336109]"}
{"concept_id": "C2752892", "aliases": [], "types": ["T042"], "canonical_name": "epithelial cell proliferation involved in salivary gland morphogenesis", "definition": "The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland. [GOC:dph, PMID:17336109]"}
{"concept_id": "C2752893", "aliases": ["regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalling"], "types": ["T043"], "definition": "Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium. [GOC:dph, PMID:17336109]", "canonical_name": "regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling"}
{"concept_id": "C2752894", "aliases": [], "types": ["T042"], "canonical_name": "dichotomous subdivision of terminal units involved in salivary gland branching", "definition": "The process in which a salivary epithelial cord bifurcates at its end. [GOC:dph]"}
{"concept_id": "C2752895", "aliases": [], "types": ["T040"], "canonical_name": "branch elongation involved in salivary gland morphogenesis", "definition": "The differential growth of the salivary branches along their axis, resulting in the growth of a branch. [GOC:dph]"}
{"concept_id": "C2752896", "aliases": ["regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalling"], "types": ["T043"], "canonical_name": "regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling", "definition": "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland. [GOC:dph]"}
{"concept_id": "C2752897", "aliases": [], "types": ["T040"], "canonical_name": "embryonic placenta morphogenesis", "definition": "The process in which the embryonic placenta is generated and organized. [GOC:dph]"}
{"concept_id": "C2752899", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell differentiation involved in embryonic placenta development", "definition": "The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer. [GOC:dph, PMID:16916377]"}
{"concept_id": "C2752900", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell morphogenesis involved in placental branching", "definition": "The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta. [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:16916377]"}
{"concept_id": "C2752901", "aliases": ["cell-cell signalling involved in placenta development"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in placenta development", "definition": "Any process that mediates the transfer of information from one cell to another. [GOC:dph, PMID:16916377]"}
{"concept_id": "C2752902", "aliases": [], "types": ["T042"], "canonical_name": "placenta blood vessel development", "definition": "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. [GOC:dph, PMID:16916377]"}
{"concept_id": "C2752903", "aliases": [], "types": ["T042"], "canonical_name": "ureteric bud morphogenesis", "definition": "The process in which the ureteric bud is generated and organized. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2752904", "aliases": [], "types": ["T042"], "canonical_name": "ureteric bud formation", "definition": "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud. [GOC:dph, PMID:16916378]"}
{"concept_id": "C2752905", "aliases": [], "types": ["T040"], "canonical_name": "ureteric bud elongation", "definition": "The developmental growth in which the ureteric bud grows along its axis beginning with the growth of the primary ureteric bud and ending when the branches of the bud have elongated. [GOC:dph, PMID:16916378]"}
{"concept_id": "C2752906", "aliases": ["bifid subdivision of terminal units involved in ureteric bud branching"], "types": ["T042"], "canonical_name": "dichotomous subdivision of terminal units involved in ureteric bud branching", "definition": "The process in which a ureteric bud bifurcates at its end. [GOC:dph, PMID:16916378]"}
{"concept_id": "C2752907", "aliases": [], "types": ["T042"], "canonical_name": "trifid subdivision of terminal units involved in ureteric bud branching", "definition": "The process in which a ureteric bud splits into three units at its end. [GOC:dph, PMID:16916378]"}
{"concept_id": "C2752908", "aliases": [], "types": ["T042"], "canonical_name": "lateral sprouting involved in ureteric bud morphogenesis", "definition": "The process in which a branch forms along the side of a ureteric bud. [GOC:dph, PMID:16916378]"}
{"concept_id": "C2752909", "aliases": [], "types": ["T040"], "canonical_name": "branch elongation involved in ureteric bud branching", "definition": "The growth of a branch of the ureteric bud along its axis. [GOC:dph, PMID:16916378]"}
{"concept_id": "C2752910", "aliases": [], "types": ["T040"], "canonical_name": "primary ureteric bud growth", "definition": "The process in which the primary ureteric bud grows along its axis dorsally toward the metanephric blastema. [GOC:dph, PMID:16916378]"}
{"concept_id": "C2752911", "aliases": ["regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalling"], "types": ["T043"], "definition": "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland. [GOC:dph, PMID:18559345]", "canonical_name": "regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling"}
{"concept_id": "C2752912", "aliases": ["epithelial-mesenchymal cell signalling"], "types": ["T043"], "definition": "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted. [GOC:dph]", "canonical_name": "epithelial-mesenchymal cell signaling"}
{"concept_id": "C2752913", "aliases": [], "types": ["T038"], "canonical_name": "regulation of prostatic bud formation", "definition": "Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. [GOC:dph]"}
{"concept_id": "C2752914", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of prostatic bud formation", "definition": "Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. [GOC:dph]"}
{"concept_id": "C2752915", "aliases": [], "types": ["T038"], "canonical_name": "regulation of branching involved in prostate gland morphogenesis", "definition": "Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem. [GOC:dph]"}
{"concept_id": "C2752916", "aliases": [], "types": ["T038"], "canonical_name": "regulation of morphogenesis of a branching structure", "definition": "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. [GOC:dph]"}
{"concept_id": "C2752917", "aliases": [], "types": ["T043"], "canonical_name": "cell differentiation involved in salivary gland development", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland. [GOC:dph]"}
{"concept_id": "C2752918", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell differentiation involved in salivary gland development", "definition": "The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland. [GOC:dph]"}
{"concept_id": "C2752919", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell maturation involved in salivary gland development", "definition": "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state. [GOC:dph]"}
{"concept_id": "C2752920", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell differentiation involved in salivary gland development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the salivary gland. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. [GOC:dph]"}
{"concept_id": "C2752921", "aliases": [], "types": ["T038"], "canonical_name": "regulation of branching involved in salivary gland morphogenesis", "definition": "Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium. [GOC:dph]"}
{"concept_id": "C2752922", "aliases": [], "types": ["T039"], "canonical_name": "regulation of cholesterol transporter activity", "definition": "Any process that modulates the rate, frequency, or extent of cholesterol transporter activity. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752923", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cholesterol transporter activity", "definition": "Any process that decreases the rate, frequency, or extent of cholesterol transporter activity. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752924", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phospholipid catabolic process", "definition": "Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752925", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phospholipid catabolic process", "definition": "Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752926", "aliases": [], "types": ["T044"], "canonical_name": "endoribonuclease inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of endoribonuclease. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752927", "aliases": [], "types": ["T044"], "canonical_name": "regulation of endoribonuclease activity", "definition": "Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752928", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ribonuclease activity", "definition": "Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752929", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ribonuclease activity", "definition": "Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752930", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of endoribonuclease activity", "definition": "Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752931", "aliases": ["DNase inhibitor activity"], "types": ["T044"], "canonical_name": "deoxyribonuclease inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of deoxyribonuclease. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752932", "aliases": [], "types": ["T043"], "canonical_name": "acinar cell differentiation involved in salivary gland development", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize an acinar cell of the salivary gland. Acinar cells are protein-secreting cells in the gland. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752933", "aliases": [], "types": ["T043"], "canonical_name": "neuron differentiation involved in salivary gland development", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the neurons of the salivary gland. [GOC:dph]"}
{"concept_id": "C2752934", "aliases": [], "types": ["T043"], "canonical_name": "cell differentiation involved in embryonic placenta development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. [GOC:dph]"}
{"concept_id": "C2752935", "aliases": [], "types": ["T043"], "canonical_name": "trophoblast giant cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. [GOC:dph, PMID:16269175]"}
{"concept_id": "C2752936", "aliases": ["spongiotrophoblast cell differentiation"], "types": ["T043"], "canonical_name": "spongiotrophoblast differentiation", "definition": "The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell. [GOC:dph, PMID:16269175]"}
{"concept_id": "C2752938", "aliases": [], "types": ["T043"], "canonical_name": "chorio-allantoic fusion", "definition": "The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois. [GOC:dph]"}
{"concept_id": "C2752939", "aliases": [], "types": ["T042"], "canonical_name": "labyrinthine layer development", "definition": "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. [GOC:dph]"}
{"concept_id": "C2752940", "aliases": [], "types": ["T042"], "canonical_name": "spongiotrophoblast layer development", "definition": "The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state. [GOC:dph]"}
{"concept_id": "C2752941", "aliases": [], "types": ["T042"], "canonical_name": "labyrinthine layer morphogenesis", "definition": "The process in which the labyrinthine layer of the placenta is generated and organized. [GOC:dph]"}
{"concept_id": "C2752942", "aliases": [], "types": ["T042"], "canonical_name": "labyrinthine layer formation", "definition": "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta. [GOC:dph]"}
{"concept_id": "C2752943", "aliases": [], "types": ["T043"], "canonical_name": "syncytiotrophoblast cell differentiation involved in labyrinthine layer development", "definition": "The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta. [GOC:dph]"}
{"concept_id": "C2752944", "aliases": [], "types": ["T042"], "canonical_name": "labyrinthine layer blood vessel development", "definition": "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. [GOC:dph]"}
{"concept_id": "C2752945", "aliases": [], "types": ["T042"], "canonical_name": "chorion development", "definition": "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane. [GOC:dph]"}
{"concept_id": "C2752946", "aliases": [], "types": ["T043"], "canonical_name": "chorionic trophoblast cell differentiation", "definition": "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer. [CL:0011101, GOC:dph, PMID:16983341]"}
{"concept_id": "C2752947", "aliases": [], "types": ["T043"], "canonical_name": "chorionic trophoblast cell development", "definition": "The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [CL:0011101, GOC:16983341, GOC:dph]"}
{"concept_id": "C2752948", "aliases": [], "types": ["T043"], "canonical_name": "spongiotrophoblast cell proliferation", "definition": "The multiplication or reproduction of spongiotrophoblast cells, resulting in the expansion of the population in the spongiotrophoblast layer. [GOC:dph]"}
{"concept_id": "C2752949", "aliases": [], "types": ["T040"], "canonical_name": "regulation of spongiotrophoblast cell proliferation", "definition": "Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation. [GOC:dph]"}
{"concept_id": "C2752950", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in embryonic placenta development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta. [GOC:dph]"}
{"concept_id": "C2752951", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in embryonic placenta development", "definition": "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development. [GOC:dph]"}
{"concept_id": "C2752952", "aliases": ["coreceptor activity involved in epidermal growth factor receptor signalling pathway"], "types": ["T044"], "canonical_name": "coreceptor activity involved in epidermal growth factor receptor signaling pathway", "definition": "Combining with an extracellular messenger, and in cooperation with a primary EGF receptor, initiating a change in cell activity through the EGF receptor signaling pathway. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752953", "aliases": [], "types": ["T044"], "canonical_name": "regulation of coreceptor activity", "definition": "Any process that modulates the rate or frequency of coreceptor activity, combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752954", "aliases": ["regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway", "regulation of Neu/ErbB-2 receptor activity"], "types": ["T044"], "canonical_name": "regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway", "definition": "Any process that modulates the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752955", "aliases": ["positive regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway", "positive regulation of Neu/ErbB-2 receptor activity"], "types": ["T044"], "canonical_name": "positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway", "definition": "Any process that increases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752956", "aliases": ["negative regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway", "negative regulation of Neu/ErbB-2 receptor activity"], "types": ["T044"], "canonical_name": "negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway", "definition": "Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752957", "aliases": ["maintenance of intestinal epithelium", "epithelial structure maintenance of intestine"], "types": ["T042"], "canonical_name": "intestinal epithelial structure maintenance", "definition": "A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752958", "aliases": [], "types": ["T039"], "canonical_name": "regulation of intestinal epithelial structure maintenance", "definition": "Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752959", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of intestinal epithelial structure maintenance", "definition": "Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752960", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of inositol phosphate biosynthetic process", "definition": "Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752962", "aliases": ["regulation of ER stress-induced eIF2 alpha phosphorylation", "regulation of eIF2 alpha phosphorylation by ER stress", "regulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation", "definition": "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752963", "aliases": ["regulation of eIF2 alpha phosphorylation by double-stranded RNA"], "types": ["T044"], "canonical_name": "regulation of eIF2 alpha phosphorylation by dsRNA", "definition": "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752964", "aliases": [], "types": ["T044"], "canonical_name": "regulation of eIF2 alpha phosphorylation by PKR"}
{"concept_id": "C2752965", "aliases": [], "types": ["T040"], "canonical_name": "prostate gland growth", "definition": "The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. [GOC:dph]"}
{"concept_id": "C2752966", "aliases": ["prostate gland growth involved in morphogenesis"], "types": ["T040"], "canonical_name": "prostate gland morphogenetic growth", "definition": "The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form. [GOC:dph]"}
{"concept_id": "C2752967", "aliases": ["mesenchymal-epithelial cell signalling involved in prostate gland development"], "types": ["T043"], "canonical_name": "mesenchymal-epithelial cell signaling involved in prostate gland development", "definition": "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time. [GOC:dph]"}
{"concept_id": "C2752968", "aliases": [], "types": ["T042"], "canonical_name": "prostate gland epithelium morphogenesis", "definition": "The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. [GOC:dph]"}
{"concept_id": "C2752969", "aliases": [], "types": ["T042"], "canonical_name": "prostate gland stromal morphogenesis", "definition": "The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland. [GOC:dph]"}
{"concept_id": "C2752970", "aliases": [], "types": ["T039"], "canonical_name": "epithelial cell differentiation involved in prostate gland development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. [GOC:dph]"}
{"concept_id": "C2752971", "aliases": ["prostate gland epithelial cell development"], "types": ["T043"], "canonical_name": "epithelial cell maturation involved in prostate gland development", "definition": "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. [GOC:dph]"}
{"concept_id": "C2752972", "aliases": ["mammary gland branching involved in puberty"], "types": ["T039"], "canonical_name": "mammary gland branching involved in thelarche", "definition": "The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, PMID:19261859]"}
{"concept_id": "C2752973", "aliases": [], "types": ["T039"], "canonical_name": "mammary gland branching involved in pregnancy", "definition": "The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy. [GOC:dph, PMID:19261859]"}
{"concept_id": "C2752974", "aliases": [], "types": ["T055"], "canonical_name": "parental behavior", "definition": "A reproductive behavior in which a parent cares for and rears offspring. [GOC:dph]"}
{"concept_id": "C2752975", "aliases": [], "types": ["T055"], "canonical_name": "oral incubation", "definition": "A parental behavior in which fertilized eggs are taken into the mouth and held until hatching. [GOC:dph]"}
{"concept_id": "C2752976", "aliases": [], "types": ["T039"], "canonical_name": "tertiary branching involved in mammary gland duct morphogenesis", "definition": "The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy. [GOC:dph, PMID:18614704]"}
{"concept_id": "C2752977", "aliases": [], "types": ["T042"], "canonical_name": "mammary gland alveolus development", "definition": "The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. [GOC:dph]"}
{"concept_id": "C2752978", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell proliferation involved in mammary gland duct elongation", "definition": "The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth. [GOC:dph]"}
{"concept_id": "C2752979", "aliases": ["mammary gland duct branch elongation"], "types": ["T042"], "canonical_name": "branch elongation involved in mammary gland duct branching", "definition": "The developmental growth process in which a branch of a mammary gland duct elongates. [GOC:dph]"}
{"concept_id": "C2752980", "aliases": [], "types": ["T042"], "canonical_name": "intestinal phytosterol absorption", "definition": "Any process in which phytosterols are taken up from the contents of the intestine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752981", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mast cell chemotaxis", "definition": "Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752982", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mast cell chemotaxis", "definition": "Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752983", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mast cell chemotaxis", "definition": "Any process that decreases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752984", "aliases": [], "types": ["T055"], "canonical_name": "foraging behavior", "definition": "Behavior by which an organism locates food. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752985", "aliases": [], "types": ["T055"], "canonical_name": "adult foraging behavior", "definition": "Behavior by which an adult locates food. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752986", "aliases": [], "types": ["T055"], "canonical_name": "foraging behavior by probing substrate", "definition": "Foraging behavior in which an anatomical part of the organism is inserted into the substrate to locate food. [GOC:dph, GOC:tb]"}
{"concept_id": "C2752987", "aliases": [], "types": ["T038"], "canonical_name": "regulation of response to cytokine stimulus", "definition": "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752988", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of response to cytokine stimulus", "definition": "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752989", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of response to cytokine stimulus", "definition": "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2752990", "aliases": [], "types": ["T038"], "canonical_name": "regulation of branching involved in mammary gland duct morphogenesis", "definition": "Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis. [GOC:dph]"}
{"concept_id": "C2752991", "aliases": [], "types": ["T040"], "canonical_name": "mammary duct terminal end bud growth", "definition": "The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty. [GOC:dph, PMID:10804170]"}
{"concept_id": "C2752992", "aliases": ["cell-cell signalling involved in mammary gland development"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in mammary gland development", "definition": "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure. [GOC:dph]"}
{"concept_id": "C2752993", "aliases": ["regulation of androgen receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of androgen receptor signaling pathway", "definition": "Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. [GOC:dph]"}
{"concept_id": "C2752994", "aliases": ["negative regulation of androgen receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of androgen receptor signaling pathway", "definition": "Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. [GOC:dph]"}
{"concept_id": "C2752995", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell proliferation involved in prostate gland development", "definition": "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time. [GOC:dph]"}
{"concept_id": "C2752996", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial cell proliferation involved in prostate gland development", "definition": "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. [GOC:dph]"}
{"concept_id": "C2752997", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of epithelial cell proliferation involved in prostate gland development", "definition": "Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. [GOC:dph]"}
{"concept_id": "C2752998", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of epithelial cell proliferation involved in prostate gland development", "definition": "Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. [GOC:dph]"}
{"concept_id": "C2752999", "aliases": [], "types": ["T042"], "canonical_name": "phyllotactic patterning", "definition": "The radial pattern formation process that results in the formation of plant organs (leaves or leaf-like structures) or flower primordia around a central axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753000", "aliases": [], "types": ["T042"], "canonical_name": "leaf phyllotactic patterning", "definition": "The radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753001", "aliases": [], "types": ["T042"], "canonical_name": "flower phyllotactic patterning", "definition": "The radial pattern formation process that results in the formation of floral organ primordia around a central axis in a flower primordium. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753002", "aliases": ["auxin mediated signalling pathway involved in phyllotactic patterning"], "types": ["T044"], "canonical_name": "auxin mediated signaling pathway involved in phyllotactic patterning", "definition": "The series of molecular signals generated in response to detection of auxin that contributes to the radial pattern formation process resulting in the formation of leaf or flower primordia around the center of a shoot apical meristem. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753003", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in gastrula mediolateral intercalation", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753004", "aliases": [], "types": ["T042"], "canonical_name": "simple leaf morphogenesis", "definition": "The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753005", "aliases": [], "types": ["T042"], "canonical_name": "compound leaf morphogenesis", "definition": "The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753006", "aliases": [], "types": ["T040"], "canonical_name": "primary leaflet morphogenesis", "definition": "The process in which the primary leaflet attains its shape. A primary leaflet is a leaflet that develops directly from the rachis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753007", "aliases": [], "types": ["T040"], "canonical_name": "secondary leaflet morphogenesis", "definition": "The process in which the secondary leaflet attains its shape. A secondary leaflet develops by branching or division of a primary leaflet. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753008", "aliases": [], "types": ["T040"], "canonical_name": "intercalary leaflet morphogenesis", "definition": "The process in which the intercalary leaflet attains its shape. An intercalary leaflet is a leaflet that develops between primary leaflets. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753009", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell proliferation involved in prostate gland development", "definition": "The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time. [GOC:dph, PMID:12221011]"}
{"concept_id": "C2753010", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mesenchymal cell proliferation involved in prostate gland development", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:dph, PMID:12221011]"}
{"concept_id": "C2753011", "aliases": ["mesenchymal smoothened signalling pathway involved in prostate gland development", "mesenchymal hedgehog signaling pathway involved in prostate gland development", "mesenchymal hh signaling pathway involved in prostate gland development"], "types": ["T044"], "canonical_name": "mesenchymal smoothened signaling pathway involved in prostate gland development", "definition": "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development. [PMID:12221011]"}
{"concept_id": "C2753012", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in tissue homeostasis", "definition": "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue. [GOC:dph]"}
{"concept_id": "C2753013", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptosis involved in tissue homeostasis", "definition": "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue. [GOC:dph]"}
{"concept_id": "C2753014", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell differentiation involved in tissue homeostasis", "definition": "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue. [GOC:dph]"}
{"concept_id": "C2753015", "aliases": ["positive regulation of posterior neural plate formation by fibroblast growth factor receptor signalling pathway", "positive regulation of posterior neural plate formation by FGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway", "definition": "Any process that increases the rate or extent of the formation of the posterior neural plate, the posterior end of the flat, thickened layer of ectodermal cells known as the neural plate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753016", "aliases": [], "types": ["T042"], "canonical_name": "ectodermal placode formation", "definition": "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753017", "aliases": [], "types": ["T042"], "canonical_name": "hair follicle placode formation", "definition": "The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753018", "aliases": [], "types": ["T042"], "canonical_name": "tooth placode formation", "definition": "The developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753019", "aliases": [], "types": ["T042"], "canonical_name": "sebaceous gland placode formation", "definition": "The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753020", "aliases": [], "types": ["T042"], "canonical_name": "sweat gland development", "definition": "The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753021", "aliases": [], "types": ["T042"], "canonical_name": "sweat gland placode formation", "definition": "The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753022", "aliases": [], "types": ["T040"], "canonical_name": "leaflet morphogenesis", "definition": "The process in which the anatomical structures of the leaflet are generated and organized. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753023", "aliases": [], "types": ["T043"], "canonical_name": "cell fate commitment involved in formation of primary germ layer", "definition": "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753025", "aliases": ["transforming growth factor beta receptor signalling pathway involved in primary germ layer cell fate commitment"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753026", "aliases": ["transforming growth factor beta receptor signalling pathway involved in mesodermal cell fate specification"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification", "definition": "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of a mesodermal fate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753027", "aliases": ["transforming growth factor beta receptor signalling pathway involved in endodermal cell fate specification"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification", "definition": "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753028", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell differentiation involved in embryonic placenta development", "definition": "Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753029", "aliases": ["negative regulation of trophoblast cell differentiation by transforming growth factor beta signalling pathway"], "types": ["T043"], "canonical_name": "negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway", "definition": "The transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753030", "aliases": ["epiblast cell-extraembryonic ectoderm cell signalling involved in anterior/posterior axis specification"], "types": ["T043"], "canonical_name": "epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification", "definition": "Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell that contributes to the specification of the anterior/posterior axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753031", "aliases": ["BMP signalling pathway involved in mesodermal cell fate specification"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in mesodermal cell fate specification", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753032", "aliases": ["positive regulation of WNT receptor signaling pathway by BMP signaling pathway", "positive regulation of WNT receptor signalling pathway by BMP signalling pathway", "positive regulation of Wnt-activated signaling pathway by BMP signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of Wnt signaling pathway by BMP signaling pathway", "definition": "The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a Wnt signaling pathway. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753033", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter", "definition": "Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753034", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell differentiation involved in embryonic placenta development", "definition": "Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753036", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of mesodermal to mesenchymal transition involved in gastrulation", "definition": "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753037", "aliases": [], "types": ["T040"], "canonical_name": "mesodermal to mesenchymal transition involved in gastrulation", "definition": "The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753038", "aliases": ["intracellular mRNA localisation involved in pattern specification process"], "types": ["T045"], "canonical_name": "intracellular mRNA localization involved in pattern specification process", "definition": "Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753039", "aliases": ["intracellular mRNA localisation involved in anterior/posterior axis specification"], "types": ["T045"], "canonical_name": "intracellular mRNA localization involved in anterior/posterior axis specification", "definition": "Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753040", "aliases": ["orthodenticle mRNA localisation"], "types": ["T045"], "canonical_name": "orthodenticle mRNA localization", "definition": "Any process in which orthodenticle mRNA is transported to and maintained in the oocyte and/or syncytial embryo as part of the process that will specify the anterior/posterior axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753041", "aliases": ["anterior mRNA localisation involved in anterior/posterior axis specification"], "types": ["T045"], "canonical_name": "anterior mRNA localization involved in anterior/posterior axis specification", "definition": "Any process in which a mRNA is transported to, and maintained in the anterior portion of the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753042", "aliases": ["posterior mRNA localisation involved in anterior/posterior axis specification"], "types": ["T045"], "canonical_name": "posterior mRNA localization involved in anterior/posterior axis specification", "definition": "Any process in which a mRNA is transported to and maintained in the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753043", "aliases": [], "types": ["T045"], "canonical_name": "regulation of translation involved in anterior/posterior axis specification", "definition": "Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753044", "aliases": [], "types": ["T045"], "canonical_name": "random inactivation of X chromosome", "definition": "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753045", "aliases": [], "types": ["T045"], "canonical_name": "inactivation of paternal X chromosome", "definition": "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753046", "aliases": [], "types": ["T045"], "canonical_name": "inactivation of paternal X chromosome by genetic imprinting"}
{"concept_id": "C2753047", "aliases": [], "types": ["T045"], "canonical_name": "inactivation of X chromosome by genetic imprinting"}
{"concept_id": "C2753048", "aliases": ["inactivation of X chromosome by heterochromatin formation"], "types": ["T045"], "canonical_name": "inactivation of X chromosome by heterochromatin assembly", "definition": "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753050", "aliases": ["transforming growth factor beta receptor signalling pathway involved in axial mesodermal cell fate specification"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in axial mesodermal cell fate specification", "definition": "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of an axial mesodermal fate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753051", "aliases": ["canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation", "canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation", "Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation", "canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the formation of the neural plate anterior/posterior pattern. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753052", "aliases": ["retinoic acid receptor signalling pathway involved in neural plate anterior/posterior pattern formation"], "types": ["T044"], "canonical_name": "retinoic acid receptor signaling pathway involved in neural plate anterior/posterior pattern formation", "definition": "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the formation of the anterior/posterior pattern of the neural plate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753053", "aliases": ["fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the anterior/posterior pattern of the neural plate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753054", "aliases": ["transforming growth factor beta receptor signalling pathway involved in neural plate anterior/posterior pattern formation"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753055", "aliases": ["regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation", "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation", "regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation", "regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation"], "types": ["T044"], "canonical_name": "regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation", "definition": "Any process that modulates the rate, frequency, or extent of Wnt signaling through beta-catenin that results in the formation of the neural plate anterior/posterior pattern. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753056", "aliases": ["regulation of Wnt receptor signaling pathway through beta-catenin", "regulation of canonical Wnt receptor signaling pathway", "regulation of canonical Wnt receptor signalling pathway", "regulation of canonical Wnt-activated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of canonical Wnt signaling pathway", "definition": "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753057", "aliases": ["negative regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation", "negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern", "negative regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern", "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation"], "types": ["T038"], "canonical_name": "negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation", "definition": "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753058", "aliases": ["ciliary receptor clustering involved in hedgehog signaling pathway", "ciliary receptor clustering involved in smoothened signalling pathway", "ciliary receptor clustering involved in hh signaling pathway"], "types": ["T044"], "canonical_name": "ciliary receptor clustering involved in smoothened signaling pathway", "definition": "Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway. [GOC:cilia, GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753059", "aliases": ["hh signaling pathway involved in dorsal/ventral neural tube patterning", "smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "hedgehog signaling pathway involved in dorsal/ventral neural tube patterning"], "types": ["T044"], "canonical_name": "smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "definition": "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753060", "aliases": [], "types": ["T043"], "canonical_name": "oocyte animal/vegetal axis specification", "definition": "The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753061", "aliases": ["Wnt receptor signaling pathway involved in animal/vegetal axis specification", "Wnt receptor signalling pathway involved in animal/vegetal axis specification", "Wnt- activated signaling pathway involved in animal/vegetal axis specification"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in animal/vegetal axis specification", "definition": "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the specification of the animal/vegetal axis of an oocyte. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753062", "aliases": ["oral/aboral axis determination"], "types": ["T040"], "canonical_name": "oral/aboral axis specification", "definition": "The establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753063", "aliases": ["transforming growth factor receptor beta signalling pathway involved in oral/aboral axis specification"], "types": ["T044"], "canonical_name": "transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753064", "aliases": [], "types": ["T043"], "canonical_name": "lymphatic endothelial cell differentiation", "definition": "The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753065", "aliases": [], "types": ["T043"], "canonical_name": "blood vessel endothelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753066", "aliases": [], "types": ["T043"], "canonical_name": "lymphatic endothelial cell fate commitment", "definition": "The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753067", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell fate commitment", "definition": "The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753068", "aliases": [], "types": ["T042"], "canonical_name": "artery development", "definition": "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753069", "aliases": [], "types": ["T042"], "canonical_name": "venous blood vessel development", "definition": "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753070", "aliases": [], "types": ["T043"], "canonical_name": "arterial endothelial cell differentiation", "definition": "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753071", "aliases": [], "types": ["T043"], "canonical_name": "venous endothelial cell differentiation", "definition": "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753072", "aliases": [], "types": ["T043"], "canonical_name": "arterial endothelial cell fate commitment", "definition": "The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753073", "aliases": [], "types": ["T043"], "canonical_name": "venous endothelial cell fate commitment", "definition": "The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753074", "aliases": [], "types": ["T043"], "canonical_name": "blood vessel endothelial cell fate commitment", "definition": "The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753075", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell fate specification", "definition": "The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753076", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell fate determination", "definition": "A process involved in cell fate commitment of an endothelial cell. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753079", "aliases": ["vascular endothelial growth factor receptor signalling pathway involved in lymphatic endothelial cell fate commitment"], "types": ["T044"], "canonical_name": "vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment", "definition": "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell fate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753081", "aliases": ["Notch signalling pathway involved in arterial endothelial cell fate commitment"], "types": ["T044"], "canonical_name": "Notch signaling pathway involved in arterial endothelial cell fate commitment", "definition": "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753082", "aliases": [], "types": ["T042"], "canonical_name": "patterning of lymph vessels"}
{"concept_id": "C2753083", "aliases": [], "types": ["T043"], "canonical_name": "venous endothelial cell migration involved in lymph vessel development", "definition": "The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753084", "aliases": ["establishment of BBB", "establishment of blood/brain barrier"], "types": ["T043"], "canonical_name": "establishment of blood-brain barrier", "definition": "Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. [GOC:aruk, GOC:dph, GOC:sart, PMID:20080302, PMID:30280653]"}
{"concept_id": "C2753085", "aliases": ["establishment of glial blood/brain barrier", "establishment of glial BBB"], "types": ["T043"], "canonical_name": "establishment of glial blood-brain barrier", "definition": "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. [GOC:dph, GOC:sart, PMID:20080302]"}
{"concept_id": "C2753086", "aliases": ["membrane trafficking involved in floral organ shedding"], "types": ["T043"], "canonical_name": "vesicle-mediated transport involved in floral organ abscission", "definition": "The directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753088", "aliases": [], "types": ["T042"], "canonical_name": "regulation of floral organ abscission", "definition": "Any process that modulates the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753089", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of floral organ abscission", "definition": "Any process that increases the rate, frequency, or extent of floral organ shedding, the controlled shedding of floral organs. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753090", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of floral organ abscission", "definition": "Any process that decreases the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753091", "aliases": [], "types": ["T043"], "canonical_name": "regulation of floral organ abscission by signal transduction", "definition": "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately modulating the rate, or extent of floral organ abscission. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753093", "aliases": ["negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signaling pathway", "definition": "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand and contributing to the decrease in the rate or frequency of floral organ abscission. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753094", "aliases": [], "types": ["T040"], "canonical_name": "leaf abscission", "definition": "The controlled shedding of a leaf. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753095", "aliases": [], "types": ["T040"], "canonical_name": "fruit abscission", "definition": "The controlled shedding of a fruit. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753097", "aliases": ["transmembrane receptor protein serine/threonine kinase signalling pathway involved in floral organ abscission"], "types": ["T044"], "canonical_name": "transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission. [GOC:dph, GOC:sdb_2009, GOC:signaling, GOC:tb]"}
{"concept_id": "C2753098", "aliases": [], "types": ["T043"], "canonical_name": "cell wall disassembly involved in floral organ abscission", "definition": "A cellular process that results in the breakdown of the cell wall that contributes to the process of floral organ abscission. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753100", "aliases": [], "types": ["T042"], "canonical_name": "semicircular canal development", "definition": "The progression of the semicircular canal from its initial formation to the mature structure. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753101", "aliases": [], "types": ["T042"], "canonical_name": "anterior semicircular canal development", "definition": "The progession of the anterior semicircular canal from its initial formation to the mature structure. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753102", "aliases": [], "types": ["T042"], "canonical_name": "posterior semicircular canal development", "definition": "The progession of the posterior semicircular canal from its initial formation to the mature structure. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753103", "aliases": [], "types": ["T042"], "canonical_name": "lateral semicircular canal development", "definition": "The progession of the lateral semicircular canal from its initial formation to the mature structure. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753104", "aliases": [], "types": ["T042"], "canonical_name": "semicircular canal formation", "definition": "The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753105", "aliases": [], "types": ["T042"], "canonical_name": "regionalization involved in semicircular canal formation", "definition": "The pattern specification process that results in the subdivision of the otic epithelium in space to define an area or volume in which cells will differentiate to give rise to the semicircular canals. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753106", "aliases": [], "types": ["T040"], "canonical_name": "pouch outgrowth involved in semicircular canal formation", "definition": "The morphogenetic process in which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753107", "aliases": [], "types": ["T042"], "canonical_name": "semicircular canal fusion", "definition": "Creation of the central hole of the semicircular canal by sealing the edges of the pouch that forms during the process of semicircular canal formation. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753108", "aliases": [], "types": ["T043"], "canonical_name": "cell morphogenesis involved in semicircular canal fusion", "definition": "The change in form (cell shape and size) that occurs when a semicircular canal epithelial cell acquires the structural features that allow it to contribute to the process of semicircular canal fusion. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753109", "aliases": [], "types": ["T043"], "canonical_name": "basal lamina disassembly"}
{"concept_id": "C2753110", "aliases": [], "types": ["T043"], "canonical_name": "basal lamina disassembly involved in semicircular canal fusion"}
{"concept_id": "C2753111", "aliases": [], "types": ["T043"], "canonical_name": "regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication"}
{"concept_id": "C2753112", "aliases": [], "types": ["T042"], "canonical_name": "clearance of cells from fusion plate", "definition": "The morphogenetic process in which cells are removed from the inner loop of a semicircular canal. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753113", "aliases": [], "types": ["T043"], "canonical_name": "clearance of cells from fusion plate by apoptosis"}
{"concept_id": "C2753114", "aliases": [], "types": ["T043"], "canonical_name": "clearance of cells from fusion plate by epithelial to mesenchymal transition", "definition": "The process of epithelial to mesenchymal transition that contributes to the shaping of the semicircular canal by effectively removing epithelial cells from the fusion plate, forming the loops of the canals. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753115", "aliases": [], "types": ["T042"], "canonical_name": "limb epidermis development", "definition": "The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753116", "aliases": [], "types": ["T042"], "canonical_name": "limb epidermis stratification", "definition": "The pattern specification process that results in the subdivision of the epidermis of the limb in space to define a volume in which specific patterns of basal cell, spinous cell and granular cells will differentiate giving rise to the layers of the limb epidermis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753117", "aliases": [], "types": ["T042"], "canonical_name": "limb basal epidermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal basal cell. A epidermal basal cell cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into more specialized cell of the limb epidermis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753118", "aliases": [], "types": ["T043"], "canonical_name": "limb spinous cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal spinous cell. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753119", "aliases": [], "types": ["T043"], "canonical_name": "limb granular cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal granular cell. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753120", "aliases": [], "types": ["T043"], "canonical_name": "limb basal epidermal cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753121", "aliases": [], "types": ["T043"], "canonical_name": "limb granular cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753122", "aliases": [], "types": ["T043"], "canonical_name": "limb spinous cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753123", "aliases": ["retinoic acid receptor signalling pathway involved in spinal cord dorsal/ventral patterning"], "types": ["T044"], "canonical_name": "retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning", "definition": "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the dorsal ventral patterning of the spinal cord. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753124", "aliases": [], "types": ["T042"], "canonical_name": "neural plate pattern specification", "definition": "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753125", "aliases": [], "types": ["T042"], "canonical_name": "neural plate regionalization", "definition": "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753126", "aliases": [], "types": ["T043"], "canonical_name": "eye field cell fate commitment involved in camera-type eye formation", "definition": "The commitment of neurectodermal cells to cells of the eye field and their capacity to differentiate into eye field cells. Eye field cells are neurectodermal cells that will form the optic placode. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753128", "aliases": [], "types": ["T042"], "canonical_name": "embryonic camera-type eye formation", "definition": "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753129", "aliases": ["regulation of hair cycle by canonical Wnt-activated signaling pathway", "regulation of hair cycle by canonical Wnt receptor signalling pathway", "regulation of hair cycle by canonical Wnt receptor signaling pathway", "regulation of hair cycle by Wnt receptor signaling pathway through beta-catenin"], "types": ["T044"], "canonical_name": "regulation of hair cycle by canonical Wnt signaling pathway", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate, frequency or extent of the hair cycle. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753130", "aliases": ["regulation of hair cycle by BMP signalling pathway"], "types": ["T044"], "canonical_name": "regulation of hair cycle by BMP signaling pathway", "definition": "The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that modulates the rate, frequency or extent of the hair cycle. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2753131", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of meiosis I", "definition": "Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753132", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein folding in endoplasmic reticulum", "definition": "Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). [GOC:dph, GOC:tb]"}
{"concept_id": "C2753133", "aliases": [], "types": ["T043"], "canonical_name": "regulation of induction of conjugation upon nitrogen starvation", "definition": "Any process that modulates the frequency of induction of conjugation upon nitrogen starvation, the process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753134", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of chromatin silencing by small RNA"}
{"concept_id": "C2753135", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of macrophage cytokine production", "definition": "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753136", "aliases": [], "types": ["T045"], "canonical_name": "plasmid copy number maintenance", "definition": "The maintenance of the number of copies of extrachromosomal plasmid DNA. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753137", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA replication initiation involved in plasmid copy number maintenance", "definition": "Any process that modulates the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753138", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of DNA replication initiation involved in plasmid copy number maintenance", "definition": "Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753139", "aliases": ["cardiocyte cell fate commitment"], "types": ["T043"], "canonical_name": "cardiac cell fate commitment", "definition": "The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. [GOC:mtg_heart]"}
{"concept_id": "C2753140", "aliases": ["cardiocyte cell fate specification"], "types": ["T043"], "canonical_name": "cardiac cell fate specification", "definition": "The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. [GOC:mtg_heart]"}
{"concept_id": "C2753141", "aliases": [], "types": ["T043"], "canonical_name": "cardiac cell fate determination", "definition": "The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. [GOC:mtg_heart]"}
{"concept_id": "C2753142", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell differentiation involved in lung development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. [GOC:dph]"}
{"concept_id": "C2753143", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell proliferation involved in lung development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:dph]"}
{"concept_id": "C2753144", "aliases": ["regulation of 1,6-beta-glucan biosynthetic process"], "types": ["T043"], "canonical_name": "regulation of (1->6)-beta-D-glucan biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753145", "aliases": [], "types": ["T043"], "canonical_name": "auxin transport", "definition": "The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Auxins are a group of plant hormones that regulates aspects of plant growth. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753146", "aliases": [], "types": ["T043"], "canonical_name": "auxin influx"}
{"concept_id": "C2753147", "aliases": [], "types": ["T043"], "canonical_name": "pacemaker cell differentiation"}
{"concept_id": "C2753148", "aliases": ["SAN cell differentiation", "SA node cell differentiation"], "types": ["T043"], "canonical_name": "sinoatrial node cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. [GOC:mtg_heart]"}
{"concept_id": "C2753149", "aliases": ["AV node cell differentiation"], "types": ["T043"], "canonical_name": "atrioventricular node cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. [GOC:mtg_heart]"}
{"concept_id": "C2753150", "aliases": ["cardiomyocyte cell fate commitment", "heart muscle cell fate commitment"], "types": ["T043"], "canonical_name": "cardiac muscle cell fate commitment", "definition": "The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. [GOC:mtg_heart]"}
{"concept_id": "C2753151", "aliases": ["atrial cardiomyocyte cell fate commitment", "atrial heart muscle cell fate commitment"], "types": ["T043"], "canonical_name": "atrial cardiac muscle cell fate commitment", "definition": "The commitment of cells to atrial cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. [GOC:mtg_heart]"}
{"concept_id": "C2753152", "aliases": ["ventricular heart muscle cell fate commitment", "ventricular cardiomyocyte cell fate commitment"], "types": ["T043"], "canonical_name": "ventricular cardiac muscle cell fate commitment", "definition": "The commitment of cells to ventricular cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the ventricle. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. [GOC:mtg_heart]"}
{"concept_id": "C2753153", "aliases": [], "types": ["T043"], "canonical_name": "pacemaker cell development"}
{"concept_id": "C2753154", "aliases": [], "types": ["T043"], "canonical_name": "pacemaker cell fate commitment"}
{"concept_id": "C2753155", "aliases": ["AV node cell development"], "types": ["T043"], "canonical_name": "atrioventricular node cell development", "definition": "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. [GOC:mtg_heart]"}
{"concept_id": "C2753156", "aliases": ["AV node cell fate commitment"], "types": ["T043"], "canonical_name": "atrioventricular node cell fate commitment", "definition": "The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells. [GOC:mtg_heart]"}
{"concept_id": "C2753157", "aliases": ["SAN cell commitment", "SA node cell commitment"], "types": ["T043"], "canonical_name": "sinoatrial node cell fate commitment", "definition": "The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node. [GOC:mtg_heart]"}
{"concept_id": "C2753158", "aliases": ["SAN cell development", "SA node cell development"], "types": ["T043"], "canonical_name": "sinoatrial node cell development", "definition": "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. [GOC:mtg_heart]"}
{"concept_id": "C2753159", "aliases": [], "types": ["T043"], "canonical_name": "His-Purkinje system cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. [GOC:mtg_heart]"}
{"concept_id": "C2753160", "aliases": [], "types": ["T043"], "canonical_name": "His-Purkinje system cell development", "definition": "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. [GOC:mtg_heart]"}
{"concept_id": "C2753161", "aliases": [], "types": ["T043"], "canonical_name": "His-Purkinje system cell fate commitment", "definition": "The commitment of cells to His-Purkinje cell fates and their capacity to differentiate into His-Purkinje cells. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. [GOC:mtg_heart]"}
{"concept_id": "C2753162", "aliases": [], "types": ["T043"], "canonical_name": "cardiac fibroblast cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]"}
{"concept_id": "C2753163", "aliases": [], "types": ["T043"], "canonical_name": "cardiac fibroblast cell development", "definition": "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]"}
{"concept_id": "C2753164", "aliases": [], "types": ["T043"], "canonical_name": "cardiac fibroblast cell fate commitment", "definition": "The commitment of cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]"}
{"concept_id": "C2753165", "aliases": [], "types": ["T043"], "canonical_name": "epicardium-derived cardiac fibroblast cell differentiation", "definition": "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]"}
{"concept_id": "C2753166", "aliases": [], "types": ["T043"], "canonical_name": "epicardium-derived cardiac fibroblast cell development", "definition": "The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]"}
{"concept_id": "C2753167", "aliases": [], "types": ["T043"], "canonical_name": "epithelial to mesenchymal transition involved in cardiac fibroblast development", "definition": "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast. [GOC:mtg_heart]"}
{"concept_id": "C2753168", "aliases": [], "types": ["T043"], "canonical_name": "epicardium-derived cardiac fibroblast cell fate commitment", "definition": "The commitment of an epicardial cell to a cardiac fibroblast cell fate and its capacity to differentiate into a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]"}
{"concept_id": "C2753169", "aliases": [], "types": ["T043"], "canonical_name": "neural crest-derived cardiac fibroblast cell differentiation", "definition": "The process in which a neural crest cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]"}
{"concept_id": "C2753170", "aliases": [], "types": ["T043"], "canonical_name": "neural crest-derived cardiac fibroblast cell development", "definition": "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation from a neural crest cell to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]"}
{"concept_id": "C2753171", "aliases": [], "types": ["T043"], "canonical_name": "neural crest-derived cardiac fibroblast cell fate commitment", "definition": "The commitment of neural crest cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]"}
{"concept_id": "C2753172", "aliases": ["heart neuron differentiation"], "types": ["T043"], "canonical_name": "cardiac neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753173", "aliases": [], "types": ["T043"], "canonical_name": "cardiac blood vessel endothelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. [GOC:mtg_heart]"}
{"concept_id": "C2753174", "aliases": ["heart vascular smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "cardiac vascular smooth muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers. [GOC:mtg_heart]"}
{"concept_id": "C2753175", "aliases": ["heart vascular smooth muscle cell development"], "types": ["T043"], "canonical_name": "cardiac vascular smooth muscle cell development", "definition": "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state. [GOC:mtg_heart]"}
{"concept_id": "C2753176", "aliases": ["heart vascular smooth muscle cell fate commitment"], "types": ["T043"], "canonical_name": "cardiac vascular smooth muscle cell fate commitment", "definition": "The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell. [GOC:mtg_heart]"}
{"concept_id": "C2753177", "aliases": [], "types": ["T043"], "canonical_name": "cardiac glial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753178", "aliases": [], "types": ["T043"], "canonical_name": "neural crest-derived cardiac glial cell differentiation", "definition": "The process in which a neural crest cell acquires the specialized features of a glial cell of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753179", "aliases": [], "types": ["T043"], "canonical_name": "cardiac glial cell development", "definition": "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. [GOC:mtg_heart]"}
{"concept_id": "C2753180", "aliases": [], "types": ["T043"], "canonical_name": "cardiac glial cell fate commitment", "definition": "The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells. [GOC:mtg_heart]"}
{"concept_id": "C2753181", "aliases": [], "types": ["T043"], "canonical_name": "neural crest-derived cardiac glial cell development", "definition": "The process aimed at the progression of a neural crest-derived cardiac glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:mtg_heart]"}
{"concept_id": "C2753182", "aliases": [], "types": ["T043"], "canonical_name": "neural crest-derived cardiac glial cell fate commitment", "definition": "The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells. [GOC:mtg_heart]"}
{"concept_id": "C2753183", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:mtg_heart]"}
{"concept_id": "C2753184", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cell fate commitment", "definition": "The commitment of a cell to an endocardial cell fate and its capacity to differentiate into an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753185", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cell development", "definition": "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753186", "aliases": ["heart neuron development"], "types": ["T043"], "canonical_name": "cardiac neuron development", "definition": "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. [GOC:mtg_heart]"}
{"concept_id": "C2753187", "aliases": ["heart neuron fate commitment"], "types": ["T043"], "canonical_name": "cardiac neuron fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753188", "aliases": [], "types": ["T044"], "canonical_name": "phospholipase D inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of phospholipase D. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753189", "aliases": ["regulation of ribosomal protein gene transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of ribosomal protein gene transcription by RNA polymerase II", "definition": "Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2753190", "aliases": ["positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "positive regulation of ribosomal protein gene transcription by RNA polymerase II", "definition": "Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II. [GOC:dph, GOC:tb, GOC:txnOH]"}
{"concept_id": "C2753191", "aliases": ["regulation of gene silencing by microRNA", "regulation of gene silencing by miRNA"], "types": ["T045"], "canonical_name": "regulation of miRNA-mediated gene silencing", "definition": "A process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs). [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604]"}
{"concept_id": "C2753192", "aliases": ["negative regulation of gene silencing by miRNA", "negative regulation of gene silencing by microRNA", "https://github.com/geneontology/go-ontology/issues/22888"], "types": ["T045"], "canonical_name": "negative regulation of miRNA-mediated gene silencing", "definition": "A process that decreases the rate, frequency, or extent of gene silencing by a microRNA (miRNA). [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604]"}
{"concept_id": "C2753193", "aliases": [], "types": ["T045"], "canonical_name": "regulation of gene silencing by RNA", "definition": "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753194", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of gene silencing by RNA", "definition": "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753197", "aliases": [], "types": ["T042"], "canonical_name": "embryonic heart tube dorsal/ventral pattern formation", "definition": "The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis. [GOC:mtg_heart]"}
{"concept_id": "C2753198", "aliases": [], "types": ["T042"], "canonical_name": "embryonic heart tube left/right pattern formation", "definition": "The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place. [GOC:mtg_heart]"}
{"concept_id": "C2753199", "aliases": [], "types": ["T042"], "canonical_name": "left/right pattern formation", "definition": "The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. [GOC:mtg_heart]"}
{"concept_id": "C2753200", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in heart development", "definition": "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. [GOC:mtg_heart]"}
{"concept_id": "C2753201", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in heart formation", "definition": "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. [GOC:mtg_heart]"}
{"concept_id": "C2753202", "aliases": ["cardiac progenitor cell midline migration", "cardioblast midline convergence"], "types": ["T042"], "canonical_name": "cardioblast migration to the midline involved in heart field formation", "definition": "The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753203", "aliases": ["cardiac vasculature development", "coronary blood vessel development", "heart vasculature development", "heart blood vessel development", "cardiac blood vessel development"], "types": ["T042"], "canonical_name": "coronary vasculature development", "definition": "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753204", "aliases": ["heart blood vessel morphogenesis", "heart vasculature morphogenesis", "cardiac vasculature morphogenesis", "coronary blood vessel morphogenesis", "cardiac blood vessel morphogenesis"], "types": ["T042"], "canonical_name": "coronary vasculature morphogenesis", "definition": "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. [GOC:mtg_heart]"}
{"concept_id": "C2753205", "aliases": ["coronary vasculature angiogenesis", "angiogenesis involved in heart vascular morphogenesis", "angiogenesis involved in cardiac vascular morphogenesis", "coronary blood vessel angiogenesis"], "types": ["T042"], "canonical_name": "angiogenesis involved in coronary vascular morphogenesis", "definition": "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. [GOC:mtg_heart]"}
{"concept_id": "C2753206", "aliases": ["coronary vasculogenesis", "vasculogenesis involved in coronary blood vessel morphogenesis"], "types": ["T042"], "canonical_name": "vasculogenesis involved in coronary vascular morphogenesis", "definition": "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. [GOC:mtg_heart]"}
{"concept_id": "C2753207", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in coronary vasculogenesis", "definition": "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753208", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in coronary angiogenesis", "definition": "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. [GOC:mtg_heart]"}
{"concept_id": "C2753209", "aliases": [], "types": ["T042"], "canonical_name": "coronary artery morphogenesis", "definition": "The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle. [GOC:mtg_heart]"}
{"concept_id": "C2753210", "aliases": [], "types": ["T043"], "canonical_name": "epicardium-derived cardiac vascular smooth muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers. [GOC:mtg_heart]"}
{"concept_id": "C2753211", "aliases": [], "types": ["T043"], "canonical_name": "epicardium-derived cardiac vascular smooth muscle cell development", "definition": "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell that was derived from the epicardium over time, from its formation to the mature state. [GOC:mtg_heart]"}
{"concept_id": "C2753212", "aliases": [], "types": ["T043"], "canonical_name": "epicardium-derived cardiac vascular smooth muscle cell fate commitment", "definition": "The commitment of an epicardial cell to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell. [GOC:mtg_heart]"}
{"concept_id": "C2753213", "aliases": [], "types": ["T042"], "canonical_name": "endocrine hormone secretion", "definition": "The regulated release of a hormone into the circulatory system. [GOC:dph]"}
{"concept_id": "C2753214", "aliases": [], "types": ["T026"], "canonical_name": "lipid tube", "definition": "A macromolecular complex that contains a tube of lipid surrounded by a protein coat. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753215", "aliases": ["lipid tubulation"], "types": ["T044"], "canonical_name": "lipid tube assembly", "definition": "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753216", "aliases": ["lipid tubulation involved in organelle fusion"], "types": ["T044"], "canonical_name": "lipid tube assembly involved in organelle fusion", "definition": "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753217", "aliases": ["lipid tubulation involved in organelle fission"], "types": ["T044"], "canonical_name": "lipid tube assembly involved in organelle fission", "definition": "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles undergo fission. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753219", "aliases": [], "types": ["T046"], "canonical_name": "response to fungicide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. [GOC:dph]"}
{"concept_id": "C2753220", "aliases": [], "types": ["T042"], "canonical_name": "kidney morphogenesis", "definition": "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2753222", "aliases": ["cell-cell signalling involved in kidney development"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in kidney development", "definition": "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2753223", "aliases": [], "types": ["T043"], "canonical_name": "dendritic spine development", "definition": "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]"}
{"concept_id": "C2753224", "aliases": [], "types": ["T043"], "canonical_name": "dendritic spine morphogenesis", "definition": "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]"}
{"concept_id": "C2753225", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendritic spine development", "definition": "Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C2753226", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of dendritic spine development", "definition": "Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C2753227", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of dendritic spine development", "definition": "Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C2753228", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendritic spine morphogenesis", "definition": "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]"}
{"concept_id": "C2753229", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of dendritic spine morphogenesis", "definition": "Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]"}
{"concept_id": "C2753230", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of dendritic spine morphogenesis", "definition": "Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]"}
{"concept_id": "C2753231", "aliases": ["pattern formation involved in kidney development", "kidney pattern specification", "kidney pattern formation"], "types": ["T042"], "canonical_name": "pattern specification involved in kidney development", "definition": "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2753232", "aliases": [], "types": ["T043"], "canonical_name": "cell differentiation involved in kidney development", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2753233", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in kidney morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2753234", "aliases": ["hepatobiliary system process"], "types": ["T039"], "canonical_name": "hepaticobiliary system process", "definition": "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. [GOC:dph]"}
{"concept_id": "C2753235", "aliases": ["hepatobiliary system development"], "types": ["T038"], "canonical_name": "hepaticobiliary system development", "definition": "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. [GOC:dph]"}
{"concept_id": "C2753236", "aliases": ["bile duct development", "CBD development"], "types": ["T042"], "canonical_name": "common bile duct development", "definition": "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gall bladder. The common bile duct transports bile from the liver and gall bladder to the intestine. [PMID:20614624]"}
{"concept_id": "C2753237", "aliases": [], "types": ["T042"], "canonical_name": "gall bladder development", "definition": "The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile. [GOC:dph]"}
{"concept_id": "C2753238", "aliases": [], "types": ["T042"], "canonical_name": "hepatic duct development", "definition": "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. [GOC:dph, PMID:20614624]"}
{"concept_id": "C2753239", "aliases": ["regulation of mRNA decay"], "types": ["T044"], "canonical_name": "regulation of mRNA catabolic process", "definition": "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753240", "aliases": ["positive regulation of mRNA decay"], "types": ["T044"], "canonical_name": "positive regulation of mRNA catabolic process", "definition": "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753241", "aliases": [], "types": ["T043"], "canonical_name": "snRNA import into nucleus", "definition": "The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753242", "aliases": [], "types": ["T043"], "canonical_name": "snRNA localization to Cajal body", "definition": "The directed movement of snRNA, small nuclear ribonucleic acid, to a Cajal body. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753243", "aliases": [], "types": ["T043"], "canonical_name": "hepatoblast differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. [GOC:dph, PMID:15226394]"}
{"concept_id": "C2753244", "aliases": ["membrane organisation", "cellular membrane organization", "membrane organization and biogenesis", "membrane organization"], "types": ["T043"], "definition": "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. [GOC:dph, GOC:tb]", "canonical_name": "cellular membrane organisation"}
{"concept_id": "C2753245", "aliases": [], "types": ["T042"], "canonical_name": "cardiac muscle tissue regeneration", "definition": "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. [GOC:dph]"}
{"concept_id": "C2753246", "aliases": [], "types": ["T042"], "canonical_name": "umbilical cord development", "definition": "The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta. [GOC:BHF, GOC:dph]"}
{"concept_id": "C2753247", "aliases": [], "types": ["T043"], "canonical_name": "establishment of endothelial barrier", "definition": "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:dph]"}
{"concept_id": "C2753248", "aliases": [], "types": ["T042"], "canonical_name": "eyelid development in camera-type eye", "definition": "The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753249", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell differentiation involved in mammary gland alveolus development", "definition": "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753250", "aliases": [], "types": ["T042"], "canonical_name": "endodermal digestive tract morphogenesis", "definition": "The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753251", "aliases": ["epicardium development"], "types": ["T042"], "canonical_name": "visceral serous pericardium development", "definition": "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753252", "aliases": ["fetal lung liquid secretion"], "types": ["T043"], "canonical_name": "secretion by lung epithelial cell involved in lung growth", "definition": "The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development. [GOC:dph]"}
{"concept_id": "C2753253", "aliases": [], "types": ["T042"], "canonical_name": "olfactory bulb mitral cell layer development", "definition": "The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer. [GOC:dph]"}
{"concept_id": "C2753254", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cartilage development", "definition": "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]"}
{"concept_id": "C2753255", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of cartilage development", "definition": "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]"}
{"concept_id": "C2753256", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of cartilage development", "definition": "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]"}
{"concept_id": "C2753257", "aliases": [], "types": ["T042"], "canonical_name": "uterus morphogenesis", "definition": "The process in which anatomical structures of the uterus are generated and organized. [GOC:BHF, GOC:dph]"}
{"concept_id": "C2753260", "aliases": [], "types": ["T039"], "canonical_name": "regulation of wound healing", "definition": "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:BHF, GOC:dph]"}
{"concept_id": "C2753261", "aliases": [], "types": ["T042"], "canonical_name": "vascular wound healing", "definition": "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:BHF, GOC:dph]"}
{"concept_id": "C2753262", "aliases": [], "types": ["T038"], "canonical_name": "regulation of vascular wound healing", "definition": "Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:dph]"}
{"concept_id": "C2753263", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of vascular wound healing", "definition": "Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:BHF, GOC:dph]"}
{"concept_id": "C2753264", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of wound healing", "definition": "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:dph]"}
{"concept_id": "C2753265", "aliases": [], "types": ["T038"], "canonical_name": "regulation of branching involved in lung morphogenesis", "definition": "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753266", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of branching involved in lung morphogenesis", "definition": "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753267", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of branching involved in lung morphogenesis", "definition": "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753268", "aliases": [], "types": ["T043"], "canonical_name": "cell growth involved in cardiac muscle cell development", "definition": "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. [GOC:dph]"}
{"concept_id": "C2753269", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscle cell hypertrophy"}
{"concept_id": "C2753270", "aliases": ["heart muscle cell growth"], "types": ["T043"], "canonical_name": "cardiomyocyte growth"}
{"concept_id": "C2753271", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell growth involved in cardiac muscle cell development", "definition": "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. [GOC:dph]"}
{"concept_id": "C2753272", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell growth involved in cardiac muscle cell development", "definition": "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. [GOC:dph]"}
{"concept_id": "C2753273", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell growth involved in cardiac muscle cell development", "definition": "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. [GOC:dph]"}
{"concept_id": "C2753274", "aliases": [], "types": ["T042"], "canonical_name": "somite development", "definition": "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. [GOC:dph]"}
{"concept_id": "C2753275", "aliases": [], "types": ["T042"], "canonical_name": "dermatome development", "definition": "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. [GOC:dph]"}
{"concept_id": "C2753276", "aliases": [], "types": ["T042"], "canonical_name": "myotome development", "definition": "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. [GOC:dph]"}
{"concept_id": "C2753277", "aliases": [], "types": ["T042"], "canonical_name": "sclerotome development", "definition": "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. [GOC:dph]"}
{"concept_id": "C2753278", "aliases": ["Imd signalling pathway", "immune deficiency pathway", "Imd signaling pathway", "PGRP signaling pathway", "immune deficiency signaling pathway"], "types": ["T077"], "canonical_name": "peptidoglycan recognition protein signaling pathway", "definition": "The series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides. [GOC:dph, PMID:18688280]"}
{"concept_id": "C2753279", "aliases": ["regulation of peptidoglycan recognition protein signalling pathway"], "types": ["T038"], "canonical_name": "regulation of peptidoglycan recognition protein signaling pathway", "definition": "Any process that modulates the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway. [GOC:dph]"}
{"concept_id": "C2753280", "aliases": ["positive regulation of peptidoglycan recognition protein signalling pathway"], "types": ["T038"], "canonical_name": "positive regulation of peptidoglycan recognition protein signaling pathway", "definition": "Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway. [GOC:dph]"}
{"concept_id": "C2753281", "aliases": ["negative regulation of peptidoglycan recognition protein signalling pathway"], "types": ["T038"], "canonical_name": "negative regulation of peptidoglycan recognition protein signaling pathway", "definition": "Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway. [GOC:dph]"}
{"concept_id": "C2753282", "aliases": [], "types": ["T042"], "canonical_name": "muscle structure development", "definition": "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. [GOC:dph]"}
{"concept_id": "C2753283", "aliases": [], "types": ["T038"], "canonical_name": "regulation of nematode larval development", "definition": "Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. [GOC:dph, GOC:kmv]"}
{"concept_id": "C2753284", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of nematode larval development", "definition": "Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. [GOC:dph, GOC:kmv]"}
{"concept_id": "C2753285", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of nematode larval development", "definition": "Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. [GOC:dph, GOC:kmv]"}
{"concept_id": "C2753286", "aliases": [], "types": ["T038"], "canonical_name": "regulation of dauer larval development", "definition": "Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. [GOC:dph, GOC:kmv]"}
{"concept_id": "C2753287", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of dauer larval development", "definition": "Any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. [GOC:dph, GOC:kmv]"}
{"concept_id": "C2753288", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of dauer larval development", "definition": "Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. [GOC:dph, GOC:kmv]"}
{"concept_id": "C2753289", "aliases": [], "types": ["T038"], "canonical_name": "urethra development", "definition": "The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. [GOC:dph]"}
{"concept_id": "C2753290", "aliases": [], "types": ["T038"], "canonical_name": "male urethra development", "definition": "The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body. [GOC:dph]"}
{"concept_id": "C2753291", "aliases": [], "types": ["T038"], "canonical_name": "female urethra development", "definition": "The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening. [GOC:dph]"}
{"concept_id": "C2753292", "aliases": [], "types": ["T039"], "canonical_name": "urethra epithelium development", "definition": "The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes. [GOC:dph]"}
{"concept_id": "C2753293", "aliases": [], "types": ["T040"], "canonical_name": "iris morphogenesis", "definition": "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. [GOC:dph]"}
{"concept_id": "C2753294", "aliases": [], "types": ["T040"], "canonical_name": "ciliary body morphogenesis", "definition": "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. [GOC:dph]"}
{"concept_id": "C2753295", "aliases": [], "types": ["T038"], "canonical_name": "regulation of neural retina development", "definition": "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. [GOC:dph]"}
{"concept_id": "C2753296", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of neural retina development", "definition": "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. [GOC:dph]"}
{"concept_id": "C2753297", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of neural retina development", "definition": "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. [GOC:dph]"}
{"concept_id": "C2753298", "aliases": ["response to platinum"], "types": ["T043"], "canonical_name": "response to platinum ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus. [GOC:sl]"}
{"concept_id": "C2753299", "aliases": [], "types": ["T043"], "canonical_name": "response to fatty acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:lp]"}
{"concept_id": "C2753300", "aliases": ["response to linoleate"], "types": ["T043"], "canonical_name": "response to linoleic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus. [GOC:lp]"}
{"concept_id": "C2753301", "aliases": ["H3K36 demethylation"], "types": ["T044"], "canonical_name": "histone H3-K36 demethylation", "definition": "The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone. [GOC:sart, PMID:19061644]"}
{"concept_id": "C2753302", "aliases": ["PeBoW complex location"], "types": ["T026"], "canonical_name": "PeBoW complex", "definition": "A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively. [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269]"}
{"concept_id": "C2753303", "aliases": [], "types": ["T044"], "canonical_name": "L-phenylalanine aminotransferase activity", "definition": "Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid. [GOC:mah]"}
{"concept_id": "C2753304", "aliases": [], "types": ["T044"], "canonical_name": "L-glutamine aminotransferase activity", "definition": "Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid. [GOC:mah]"}
{"concept_id": "C2753305", "aliases": ["RNA interference, negative regulation of translation", "negative regulation of translation involved in RNA interference", "inhibition of translation involved in RNA interference", "downregulation of translation involved in RNA interference", "down-regulation of translation involved in RNA interference", "down regulation of translation involved in RNA interference"], "types": ["T045"], "canonical_name": "siRNA-mediated gene silencing by inhibition of translation", "definition": "An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs. [GOC:mah, PMID:18771919]"}
{"concept_id": "C2753306", "aliases": ["rDNA condensation", "rDNA packaging"], "types": ["T043"], "canonical_name": "rDNA chromatin condensation", "definition": "The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase. [GOC:dgf, PMID:10811823, PMID:15137940]"}
{"concept_id": "C2753307", "aliases": ["argonaute endoribonuclease activity"], "types": ["T045"], "canonical_name": "endoribonuclease activity, cleaving siRNA-paired mRNA", "definition": "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters. [GOC:mah, PMID:15105377]"}
{"concept_id": "C2753308", "aliases": ["BRISC complex location"], "types": ["T026"], "canonical_name": "BRISC complex", "definition": "A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains. [GOC:mah, PMID:19214193]"}
{"concept_id": "C2753309", "aliases": ["niacin receptor activity"], "types": ["T044"], "canonical_name": "nicotinic acid receptor activity", "definition": "Combining with nicotinic acid to initiate a change in cell activity. [GOC:mah, PMID:12522134]"}
{"concept_id": "C2753310", "aliases": ["Stx3-Snap25-Vamp2-Cplx1 complex", "SNARE complex (Stx3, Snap25, Vamp2, Cplx1)", "SNARE complex location (Stx3, Snap25, Vamp2, Cplx1)", "Stx3-Snap25-Vamp2-Cplx1 complex location", "synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex location"], "types": ["T026"], "canonical_name": "synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex", "definition": "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof). [PMID:8824312]"}
{"concept_id": "C2753311", "aliases": ["response to IL-1"], "types": ["T043"], "canonical_name": "response to interleukin-1", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753312", "aliases": ["TFIID complex location, B-cell specific", "TAF4B-containing transcription factor TFIID complex location", "TFIID complex, B-cell specific"], "types": ["T026"], "canonical_name": "TAF4B-containing transcription factor TFIID complex", "definition": "A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4. [GOC:mah, PMID:8858156]"}
{"concept_id": "C2753313", "aliases": ["PCNA-p21 complex location"], "types": ["T026"], "canonical_name": "PCNA-p21 complex", "definition": "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication. [GOC:mah, PMID:7911228, PMID:7915843]"}
{"concept_id": "C2753314", "aliases": ["ITGAM-ITGB2-CD63 complex", "ITGAM-ITGB2-CD63 complex location", "alphaM-beta2 integrin-CD63 complex location"], "types": ["T026"], "canonical_name": "alphaM-beta2 integrin-CD63 complex", "definition": "A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family. [PMID:8871662]"}
{"concept_id": "C2753315", "aliases": ["GALNS-lysosomal hydrolase 1.27 MDa complex", "GALNS-lysosomal hydrolase 1.27 MDa complex location", "lysosomal multienzyme complex location"], "types": ["T026"], "canonical_name": "lysosomal multienzyme complex", "definition": "A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism. [GOC:mah, PMID:8910459]"}
{"concept_id": "C2753316", "aliases": [], "types": ["T043"], "canonical_name": "protein secretion by platelet", "definition": "The regulated release of proteins by a platelet or group of platelets. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753317", "aliases": ["VDR signaling pathway", "vitamin D receptor signalling pathway"], "types": ["T044"], "canonical_name": "vitamin D receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands. [GOC:BHF, GOC:mah, PMID:12637589]"}
{"concept_id": "C2753318", "aliases": ["regulation of vitamin D receptor signalling pathway", "regulation of VDR signaling pathway"], "types": ["T044"], "canonical_name": "regulation of vitamin D receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753319", "aliases": ["negative regulation vitamin D receptor signalling pathway", "inhibition of vitamin D receptor signaling pathway", "downregulation of vitamin D receptor signaling pathway", "down-regulation of vitamin D receptor signaling pathway", "negative regulation of VDR signalling pathway", "negative regulation of VDR signaling pathway", "down regulation of vitamin D receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of vitamin D receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753320", "aliases": ["positive regulation of VDR signaling pathway", "up-regulation of vitamin D receptor signaling pathway", "positive regulation of vitamin D receptor signalling pathway", "up regulation of vitamin D receptor signaling pathway", "upregulation of vitamin D receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of vitamin D receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753321", "aliases": ["telomere-telomerase complex location"], "types": ["T026"], "canonical_name": "telomere-telomerase complex", "definition": "A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome. [GOC:pde, PMID:19179534]"}
{"concept_id": "C2753322", "aliases": [], "types": ["T044"], "canonical_name": "adenylyltransferase activity", "definition": "Catalysis of the transfer of an adenylyl group to an acceptor. [GOC:mah]"}
{"concept_id": "C2753323", "aliases": [], "types": ["T044"], "canonical_name": "cytidylyltransferase activity", "definition": "Catalysis of the transfer of a cytidylyl group to an acceptor. [GOC:mah]"}
{"concept_id": "C2753324", "aliases": [], "types": ["T044"], "canonical_name": "guanylyltransferase activity", "definition": "Catalysis of the transfer of a guanylyl group to an acceptor. [GOC:mah]"}
{"concept_id": "C2753325", "aliases": ["uridyltransferase activity", "uridyl transferase activity"], "types": ["T044"], "canonical_name": "uridylyltransferase activity", "definition": "Catalysis of the transfer of an uridylyl group to an acceptor. [GOC:mah]"}
{"concept_id": "C2753326", "aliases": [], "types": ["T038"], "canonical_name": "regulation of neuron projection regeneration", "definition": "Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. [GOC:mah]"}
{"concept_id": "C2753327", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of neuron projection regeneration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. [GOC:mah]"}
{"concept_id": "C2753328", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of neuron projection regeneration", "definition": "Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. [GOC:mah]"}
{"concept_id": "C2753329", "aliases": ["metallo-exo-dipeptidase activity", "metalloexodipeptidase activity"], "types": ["T044"], "canonical_name": "metallodipeptidase activity", "definition": "Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]"}
{"concept_id": "C2753330", "aliases": ["transmembrane cadmium transport", "cadmium ion membrane transport"], "types": ["T044"], "canonical_name": "cadmium ion transmembrane transport", "definition": "A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2753331", "aliases": ["peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation", "peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation"], "types": ["T044"], "canonical_name": "peptide mating pheromone maturation involved in regulation of pheromone-induced unidirectional conjugation", "definition": "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation. [GOC:mah]"}
{"concept_id": "C2753332", "aliases": ["cholecalciferol 24-hydroxylase activity", "calciferol 24-hydroxylase activity", "ergocalciferol 24-hydroxylase activity", "vitamin D3 24-hydroxylase activity", "vitamin D2 24-hydroxylase activity"], "types": ["T044"], "canonical_name": "vitamin D 24-hydroxylase activity", "definition": "Catalysis of the hydroxylation of C-24 of any form of vitamin D. [GOC:BHF, GOC:mah, PMID:15546903]"}
{"concept_id": "C2753333", "aliases": ["acetylated histone residue binding"], "types": ["T044"], "canonical_name": "lysine-acetylated histone binding", "definition": "Binding to a histone in which a lysine residue has been modified by acetylation. [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]"}
{"concept_id": "C2753334", "aliases": ["microRNA loading complex location", "RISC-loading complex", "RLC", "microRNA loading complex", "miRLC"], "types": ["T026"], "definition": "A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710]", "canonical_name": "RISC-loading complex location"}
{"concept_id": "C2753335", "aliases": [], "types": ["T044"], "canonical_name": "methylcytosine dioxygenase activity", "definition": "Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2. [PMID:19372391]"}
{"concept_id": "C2753336", "aliases": ["beta-D-glucosyl-HOMedU metabolic process", "beta-D-glucosyl-hydroxymethyluracil metabolism", "base J metabolism"], "types": ["T044"], "canonical_name": "base J metabolic process", "definition": "The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J. [PMID:19114062]"}
{"concept_id": "C2753337", "aliases": ["rolling circle replication"], "types": ["T045"], "canonical_name": "rolling circle DNA replication", "definition": "A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon. [GOC:cb, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2753338", "aliases": ["theta replication"], "types": ["T045"], "canonical_name": "theta DNA replication", "definition": "A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template. [GOC:cb, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2753339", "aliases": ["FSM bending", "ascospore-type prospore membrane bending", "forespore membrane bending"], "types": ["T043"], "canonical_name": "spore membrane bending pathway", "definition": "The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore. [GOC:dgf, PMID:18756268]"}
{"concept_id": "C2753340", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrion morphogenesis", "definition": "The process in which the anatomical structures of a mitochondrion are generated and organized. [GOC:mah]"}
{"concept_id": "C2753341", "aliases": ["protein localization in mitochondrion", "protein localisation in mitochondrion"], "types": ["T043"], "canonical_name": "protein localization to mitochondrion", "definition": "A process in which a protein is transported to, or maintained in, a location within the mitochondrion. [GOC:ecd]"}
{"concept_id": "C2753342", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in gastrulation", "definition": "The attachment of one cell to another cell affecting gastrulation. [GOC:dsf, PMID:19091770]"}
{"concept_id": "C2753343", "aliases": [], "types": ["T039"], "canonical_name": "regulation of cell-cell adhesion involved in gastrulation", "definition": "Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation. [GOC:dsf, PMID:19091770]"}
{"concept_id": "C2753344", "aliases": ["calcium ion membrane transport", "transmembrane calcium transport"], "types": ["T044"], "canonical_name": "calcium ion transmembrane transport", "definition": "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2753345", "aliases": ["cellular component macromolecule biosynthesis"], "types": ["T043"], "canonical_name": "cellular component macromolecule biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component. [GOC:mah]"}
{"concept_id": "C2753346", "aliases": [], "types": ["T043"], "canonical_name": "spore wall biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore. [GOC:mah]"}
{"concept_id": "C2753347", "aliases": [], "types": ["T043"], "canonical_name": "ascospore wall biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall. [GOC:mah]"}
{"concept_id": "C2753348", "aliases": ["cell wall polysaccharide anabolism", "cell wall polysaccharide synthesis", "cell wall polysaccharide biosynthesis"], "types": ["T043"], "definition": "The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall. [GOC:mah]", "canonical_name": "cell wall polysaccharide biosynthetic process"}
{"concept_id": "C2753349", "aliases": ["dendrite repulsion"], "types": ["T043"], "canonical_name": "dendrite self-avoidance", "definition": "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell. [GOC:sart, PMID:17482551]"}
{"concept_id": "C2753350", "aliases": ["JHRE binding"], "types": ["T045"], "canonical_name": "juvenile hormone response element binding", "definition": "Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone. [GOC:sart, PMID:17956872]"}
{"concept_id": "C2753351", "aliases": ["1,3-alpha-glucan metabolic process", "alpha-1,3 glucan metabolism", "alpha-1,3 glucan metabolic process", "1,3-alpha-glucan metabolism"], "types": ["T044"], "canonical_name": "(1->3)-alpha-glucan metabolic process", "definition": "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds. [GOC:mah]"}
{"concept_id": "C2753352", "aliases": ["1,3-alpha-glucan biosynthesis", "1,3-alpha-glucan anabolism", "alpha-1,3 glucan anabolism", "alpha-1,3 glucan biosynthetic process", "alpha-1,3 glucan synthesis", "1,3-alpha-glucan biosynthetic process", "alpha-1,3 glucan biosynthesis", "1,3-alpha-glucan synthesis", "alpha-1,3 glucan formation", "1,3-alpha-glucan formation"], "types": ["T044"], "canonical_name": "(1->3)-alpha-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds. [GOC:mah]"}
{"concept_id": "C2753353", "aliases": ["cell wall alpha-1,3 glucan metabolic process", "cell wall 1,3-alpha-glucan metabolic process", "cell wall 1,3-alpha-glucan metabolism", "cell wall alpha-1,3 glucan metabolism"], "types": ["T044"], "canonical_name": "cell wall (1->3)-alpha-glucan metabolic process", "definition": "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells. [GOC:mah]"}
{"concept_id": "C2753354", "aliases": ["cell wall alpha-1,3-glucan formation", "cell wall alpha-1,3-glucan biosynthesis", "cell wall alpha-1,3-glucan anabolism", "cell wall 1,3-alpha-glucan anabolism", "cell wall 1,3-alpha-glucan formation", "cell wall alpha-1,3-glucan biosynthetic process", "cell wall 1,3-alpha-glucan biosynthesis", "cell wall 1,3-alpha-glucan biosynthetic process", "cell wall alpha-1,3-glucan synthesis", "cell wall 1,3-alpha-glucan synthesis"], "types": ["T044"], "canonical_name": "cell wall (1->3)-alpha-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-glucosidic bonds, found in the walls of cells. [GOC:mah]"}
{"concept_id": "C2753355", "aliases": ["ascospore wall alpha-1,3 glucan metabolism", "ascospore wall 1,3-alpha-glucan metabolism", "ascospore wall alpha-1,3 glucan metabolic process", "ascospore wall 1,3-alpha-glucan metabolic process"], "types": ["T044"], "canonical_name": "fungal-type cell wall (1->3)-alpha-glucan metabolic process", "definition": "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores. [GOC:mah]"}
{"concept_id": "C2753356", "aliases": ["fungal-type cell wall 1,3-alpha-glucan formation", "fungal-type cell wall alpha-1,3-glucan synthesis", "fungal-type cell wall 1,3-alpha-glucan synthesis", "fungal-type cell wall alpha-1,3-glucan formation", "fungal-type cell wall alpha-1,3-glucan biosynthesis", "fungal-type cell wall 1,3-alpha-glucan biosynthesis", "fungal-type cell wall alpha-1,3-glucan anabolism", "fungal-type cell wall 1,3-alpha-glucan biosynthetic process", "fungal-type cell wall 1,3-alpha-glucan anabolism", "fungal-type cell wall alpha-1,3-glucan biosynthetic process"], "types": ["T044"], "canonical_name": "fungal-type cell wall (1->3)-alpha-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores. [GOC:mah]"}
{"concept_id": "C2753357", "aliases": ["sister chromatid cohesion at centromere"], "types": ["T043"], "canonical_name": "centromeric sister chromatid cohesion", "definition": "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome. [GOC:mah]"}
{"concept_id": "C2753358", "aliases": ["regulation of sister chromatid cohesion at centromere"], "types": ["T043"], "canonical_name": "regulation of centromeric sister chromatid cohesion", "definition": "Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome. [GOC:mah]"}
{"concept_id": "C2753359", "aliases": ["BAF-type complex location", "SWI/SNF-type complex", "BAF-type complex", "SWI/SNF-type complex location", "SWI/SNF superfamily-type complex location", "SWI-SNF-type complex", "SWI-SNF-type complex location"], "types": ["T026"], "canonical_name": "SWI/SNF superfamily-type complex", "definition": "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]"}
{"concept_id": "C2753360", "aliases": ["SWI-SNF global transcription activator complex location"], "types": ["T026"], "canonical_name": "SWI-SNF global transcription activator complex"}
{"concept_id": "C2753362", "aliases": ["regulation of alpha-1,3 glucan metabolic process", "regulation of 1,3-alpha-glucan metabolism", "regulation of alpha-1,3 glucan metabolism", "regulation of 1,3-alpha-glucan metabolic process"], "types": ["T043"], "canonical_name": "regulation of (1->3)-alpha-glucan metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds. [GOC:mah]"}
{"concept_id": "C2753363", "aliases": ["regulation of alpha-1,3 glucan biosynthesis", "regulation of alpha-1,3 glucan anabolism", "regulation of alpha-1,3 glucan synthesis", "regulation of 1,3-alpha-glucan synthesis", "regulation of 1,3-alpha-glucan anabolism", "regulation of 1,3-alpha-glucan formation", "regulation of 1,3-alpha-glucan biosynthesis", "regulation of alpha-1,3 glucan formation", "regulation of 1,3-alpha-glucan biosynthetic process", "regulation of alpha-1,3 glucan biosynthetic process"], "types": ["T043"], "canonical_name": "regulation of (1->3)-alpha-glucan biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds. [GOC:mah]"}
{"concept_id": "C2753364", "aliases": ["regulation of cell wall alpha-1,3 glucan metabolism", "regulation of cell wall alpha-1,3 glucan metabolic process", "regulation of cell wall 1,3-alpha-glucan metabolic process", "regulation of cell wall 1,3-alpha-glucan metabolism"], "types": ["T043"], "canonical_name": "regulation of cell wall (1->3)-alpha-glucan metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells. [GOC:mah]"}
{"concept_id": "C2753365", "aliases": ["regulation of cell wall alpha-1,3-glucan anabolism", "regulation of cell wall alpha-1,3-glucan formation", "regulation of cell wall 1,3-alpha-glucan anabolism", "regulation of cell wall 1,3-alpha-glucan formation", "regulation of cell wall alpha-1,3-glucan biosynthesis", "regulation of cell wall alpha-1,3-glucan synthesis", "regulation of cell wall 1,3-alpha-glucan synthesis", "regulation of cell wall 1,3-alpha-glucan biosynthetic process", "regulation of cell wall alpha-1,3-glucan biosynthetic process", "regulation of cell wall 1,3-alpha-glucan biosynthesis"], "types": ["T043"], "canonical_name": "regulation of cell wall (1->3)-alpha-glucan biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells. [GOC:mah]"}
{"concept_id": "C2753366", "aliases": ["regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process", "regulation of ascospore wall 1,3-alpha-glucan metabolism", "regulation of ascospore wall alpha-1,3 glucan metabolism", "regulation of ascospore wall alpha-1,3 glucan metabolic process"], "types": ["T043"], "canonical_name": "regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores. [GOC:mah]"}
{"concept_id": "C2753367", "aliases": ["regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process", "regulation of fungal-type cell wall 1,3-alpha-glucan anabolism", "regulation of fungal-type cell wall alpha-1,3-glucan synthesis", "regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis", "regulation of fungal-type cell wall alpha-1,3-glucan formation", "regulation of fungal-type cell wall alpha-1,3-glucan anabolism", "regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis", "regulation of fungal-type cell wall 1,3-alpha-glucan synthesis", "regulation of fungal-type cell wall 1,3-alpha-glucan formation", "regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process"], "types": ["T043"], "canonical_name": "regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores. [GOC:mah]"}
{"concept_id": "C2753368", "aliases": ["histone methylase activity (H3-R2 specific)", "histone-arginine N-methyltransferase activity (H3-R2 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-R2 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3. [GOC:mah, PMID:17898714]"}
{"concept_id": "C2753369", "aliases": ["histone-arginine N-methyltransferase activity (H2A-R3 specific)", "histone methylase activity (H2A-R3 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H2A-R3 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A. [GOC:mah, PMID:17898714]"}
{"concept_id": "C2753370", "aliases": ["regulation of protein maturation by peptide bond cleavage"], "types": ["T045"], "canonical_name": "regulation of protein processing", "definition": "Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. [GOC:mah]"}
{"concept_id": "C2753371", "aliases": [], "types": ["T043"], "canonical_name": "tungstate ion transport", "definition": "The directed movement of tungstate (WO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten. [GOC:dh]"}
{"concept_id": "C2753373", "aliases": ["regulation of thiamine diphosphate formation", "regulation of thiamine diphosphate synthesis", "regulation of thiamin diphosphate biosynthetic process", "regulation of thiamine diphosphate anabolism", "regulation of thiamine diphosphate biosynthesis"], "types": ["T044"], "canonical_name": "regulation of thiamine diphosphate biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate. [GOC:mah]"}
{"concept_id": "C2753374", "aliases": ["negative regulation of thiamin diphosphate biosynthetic process", "negative regulation of thiamine diphosphate biosynthesis", "negative regulation of thiamine diphosphate formation", "downregulation of thiamine diphosphate biosynthetic process", "negative regulation of thiamine diphosphate synthesis", "down-regulation of thiamine diphosphate biosynthetic process", "negative regulation of thiamine diphosphate anabolism", "down regulation of thiamine diphosphate biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of thiamine diphosphate biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate. [GOC:mah]"}
{"concept_id": "C2753375", "aliases": ["Grb2-mSos1 complex location", "Grb2-mSos1 complex", "Grb2-Sos complex location"], "types": ["T026"], "canonical_name": "Grb2-Sos complex", "definition": "A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. [GOC:mah, PMID:7798267, PMID:8940013]"}
{"concept_id": "C2753376", "aliases": ["Shc-Grb2-Sos complex location", "Shc-Grb2-mSos1 complex, EGF stimulated", "Shc-Grb2-mSos1 complex location, EGF stimulated"], "types": ["T026"], "canonical_name": "Shc-Grb2-Sos complex", "definition": "A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. [GOC:mah, PMID:7970708, PMID:8940013]"}
{"concept_id": "C2753377", "aliases": ["Egfr-Grb2-mSos1 complex, EGF stimulated", "EGFR-Grb2-Sos complex location", "Egfr-Grb2-mSos1 complex location, EGF stimulated"], "types": ["T026"], "canonical_name": "EGFR-Grb2-Sos complex", "definition": "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. [GOC:mah, PMID:7798267, PMID:8940013]"}
{"concept_id": "C2753378", "aliases": ["EGFR-Shc-Grb2-Sos complex location"], "types": ["T026"], "canonical_name": "EGFR-Shc-Grb2-Sos complex", "definition": "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. [GOC:mah, PMID:7798267, PMID:8940013]"}
{"concept_id": "C2753379", "aliases": ["UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex location", "UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex location", "UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex"], "types": ["T026"], "canonical_name": "UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex", "definition": "A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits. [GOC:mah, PMID:8940155]"}
{"concept_id": "C2753380", "aliases": ["N-acetylglucosamine-1-phosphotransferase complex location"], "types": ["T026"], "canonical_name": "N-acetylglucosamine-1-phosphotransferase complex"}
{"concept_id": "C2753381", "aliases": ["regulation of thiamine formation", "regulation of thiamine biosynthesis", "regulation of thiamine synthesis", "regulation of thiamine anabolism", "regulation of thiamin biosynthetic process"], "types": ["T044"], "canonical_name": "regulation of thiamine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine. [GOC:mah]"}
{"concept_id": "C2753382", "aliases": ["down-regulation of thiamine biosynthetic process", "negative regulation of thiamine formation", "downregulation of thiamine biosynthetic process", "negative regulation of thiamine biosynthesis", "negative regulation of thiamine synthesis", "negative regulation of thiamin biosynthetic process", "negative regulation of thiamine anabolism", "down regulation of thiamine biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of thiamine biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine. [GOC:mah]"}
{"concept_id": "C2753383", "aliases": [], "types": ["T043"], "canonical_name": "zymogen granule exocytosis", "definition": "The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions. [GOC:BHF, GOC:vk, PMID:17442889]"}
{"concept_id": "C2753384", "aliases": [], "types": ["T044"], "canonical_name": "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity"}
{"concept_id": "C2753385", "aliases": ["ferrous iron uptake", "ferrous iron import"], "types": ["T043"], "canonical_name": "ferrous ion import"}
{"concept_id": "C2753386", "aliases": ["(1->4)-alpha-D-glucan metabolism", "1,4-alpha-D-glucan metabolism", "1,4-alpha-glucan metabolism", "alpha-1,4 glucan metabolic process", "alpha-1,4 glucan metabolism"], "types": ["T044"], "canonical_name": "(1->4)-alpha-glucan metabolic process", "definition": "The chemical reactions and pathways involving (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds. [GOC:mah]"}
{"concept_id": "C2753387", "aliases": ["(1->4)-alpha-D-glucan synthesis", "(1->4)-alpha-D-glucan formation", "1,4-alpha-glucan anabolism", "alpha-1,4 glucan synthesis", "1,4-alpha-glucan formation", "1,4-alpha-glucan biosynthesis", "alpha-1,4 glucan formation", "1,4-alpha-glucan biosynthetic process", "alpha-1,4 glucan biosynthesis", "(1->4)-alpha-D-glucan anabolism", "1,4-alpha-glucan synthesis", "alpha-1,4 glucan anabolism", "(1->4)-alpha-D-glucan biosynthesis", "alpha-1,4 glucan biosynthetic process"], "types": ["T044"], "canonical_name": "(1->4)-alpha-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds. [GOC:mah]"}
{"concept_id": "C2753388", "aliases": ["spindle pole body localisation"], "types": ["T043"], "canonical_name": "spindle pole body localization", "definition": "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells. [GOC:mah]"}
{"concept_id": "C2753390", "aliases": [], "types": ["T043"], "canonical_name": "transepithelial transport", "definition": "The directed movement of a substance from one side of an epithelium to the other. [GOC:mah, GOC:yaf, ISBN:0716731363]"}
{"concept_id": "C2753391", "aliases": [], "types": ["T043"], "canonical_name": "transepithelial ammonium transport", "definition": "The directed movement of ammonium ions from one side of an epithelium to the other. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2753392", "aliases": ["N-ribosylnicotinamide hydrolase activity", "nicotinamide ribonucleoside hydrolase activity"], "types": ["T044"], "canonical_name": "nicotinamide riboside hydrolase activity", "definition": "Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose. [MetaCyc:RXN-8441, PMID:19001417]"}
{"concept_id": "C2753393", "aliases": ["nicotinate ribonucleoside hydrolase activity", "nicotinate riboside hydrolase activity", "D-ribosylnicotinate hydrolase activity", "nicotinic acid ribonucleoside hydrolase activity", "D-ribosylnicotinic acid hydrolase activity"], "types": ["T044"], "canonical_name": "nicotinic acid riboside hydrolase activity", "definition": "Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose. [GOC:mah, PMID:19001417]"}
{"concept_id": "C2753394", "aliases": ["pyridine nucleoside metabolism"], "types": ["T044"], "canonical_name": "pyridine nucleoside metabolic process", "definition": "The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose. [GOC:mah]"}
{"concept_id": "C2753395", "aliases": ["pyridine nucleoside breakdown", "pyridine nucleoside catabolism", "pyridine nucleoside degradation"], "types": ["T044"], "canonical_name": "pyridine nucleoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose. [GOC:mah]"}
{"concept_id": "C2753396", "aliases": ["vitamin D4 metabolism"], "types": ["T044"], "canonical_name": "vitamin D4 metabolic process", "definition": "The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753397", "aliases": ["vitamin D5 metabolism"], "types": ["T044"], "canonical_name": "vitamin D5 metabolic process", "definition": "The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol. [GOC:BHF, GOC:mah, PubChem_Compound:9547700]"}
{"concept_id": "C2753398", "aliases": ["calciferol 25-hydroxylase activity"], "types": ["T044"], "canonical_name": "vitamin D 25-hydroxylase activity", "definition": "Catalysis of the hydroxylation of C-25 of any form of vitamin D. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753399", "aliases": ["VDRE binding"], "types": ["T045"], "canonical_name": "vitamin D response element binding", "definition": "Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. [GOC:BHF, GOC:vk, PMID:17426122]"}
{"concept_id": "C2753400", "aliases": ["orbicule"], "types": ["T026"], "canonical_name": "Ubisch body", "definition": "A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development. [GOC:ecd, GOC:mah, PMID:14612572, PMID:16524248]"}
{"concept_id": "C2753401", "aliases": [], "types": ["T044"], "canonical_name": "protein modification by small protein removal", "definition": "A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. [GOC:mah]"}
{"concept_id": "C2753402", "aliases": [], "types": ["T044"], "canonical_name": "protein modification by small protein conjugation or removal", "definition": "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. [GOC:mah]"}
{"concept_id": "C2753403", "aliases": [], "types": ["T026"], "canonical_name": "formin-nucleated actin cable", "definition": "An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth. [PMID:14671023, PMID:16959963]"}
{"concept_id": "C2753404", "aliases": ["formin-nucleated actin cable formation"], "types": ["T043"], "canonical_name": "formin-nucleated actin cable assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. [GOC:mah, PMID:14671023, PMID:16959963]"}
{"concept_id": "C2753405", "aliases": [], "types": ["T043"], "canonical_name": "actin filament bundle distribution", "definition": "Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell. [GOC:mah]"}
{"concept_id": "C2753406", "aliases": ["NRD"], "types": ["T045"], "canonical_name": "nonfunctional rRNA decay", "definition": "An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system. [GOC:mah, GOC:rn, PMID:17188037, PMID:19390089]"}
{"concept_id": "C2753407", "aliases": ["HAUS complex location", "HAUS augmin complex location", "HAUS augmin complex"], "types": ["T026"], "canonical_name": "HAUS complex", "definition": "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex. [PMID:19427217]"}
{"concept_id": "C2753408", "aliases": ["high-density lipoprotein receptor binding", "HDL receptor binding"], "types": ["T044"], "canonical_name": "high-density lipoprotein particle receptor binding", "definition": "Binding to a high-density lipoprotein receptor. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753409", "aliases": [], "types": ["T042"], "canonical_name": "sensory epithelium regeneration", "definition": "The regrowth of a sensory epithelium following its loss or destruction. [GOC:dsf, PMID:19381250]"}
{"concept_id": "C2753410", "aliases": [], "types": ["T042"], "canonical_name": "mechanosensory epithelium regeneration", "definition": "The regrowth of lost or destroyed mechanosensory epithelia. [GOC:dsf, PMID:19381250]"}
{"concept_id": "C2753411", "aliases": [], "types": ["T043"], "canonical_name": "mechanoreceptor differentiation involved in mechanosensory epithelium regeneration", "definition": "Differentiation of new mechanoreceptors to replace those lost or destroyed by injury. [GOC:dsf, PMID:19381250]"}
{"concept_id": "C2753412", "aliases": [], "types": ["T042"], "canonical_name": "neuromast regeneration", "definition": "The regrowth of a neuromast following its loss or destruction. [GOC:dsf, PMID:19381250]"}
{"concept_id": "C2753413", "aliases": [], "types": ["T043"], "canonical_name": "neuromast hair cell differentiation involved in neuromast regeneration", "definition": "Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury. [GOC:dsf, PMID:19381250]"}
{"concept_id": "C2753414", "aliases": [], "types": ["T042"], "canonical_name": "inner ear sensory epithelium regeneration", "definition": "The regrowth of lost or destroyed inner ear sensory epithelia. [GOC:dsf, PMID:19381250]"}
{"concept_id": "C2753415", "aliases": [], "types": ["T043"], "canonical_name": "inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration", "definition": "Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury. [GOC:dsf, PMID:19381250]"}
{"concept_id": "C2753416", "aliases": [], "types": ["T043"], "canonical_name": "mast cell proliferation", "definition": "The expansion of a mast cell population by cell division. [GOC:add]"}
{"concept_id": "C2753417", "aliases": [], "types": ["T043"], "canonical_name": "regulation of leukocyte proliferation", "definition": "Any process that modulates the frequency, rate or extent of leukocyte proliferation. [GOC:add, GOC:mah]"}
{"concept_id": "C2753418", "aliases": ["downregulation of leukocyte proliferation", "down-regulation of leukocyte proliferation", "down regulation of leukocyte proliferation", "inhibition of leukocyte proliferation"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. [GOC:add, GOC:mah]"}
{"concept_id": "C2753419", "aliases": ["up regulation of leukocyte proliferation", "stimulation of leukocyte proliferation", "activation of leukocyte proliferation", "upregulation of leukocyte proliferation", "up-regulation of leukocyte proliferation"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. [GOC:add, GOC:mah]"}
{"concept_id": "C2753420", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mast cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of mast cell proliferation. [GOC:add, GOC:mah]"}
{"concept_id": "C2753421", "aliases": ["downregulation of mast cell proliferation", "inhibition of mast cell proliferation", "down regulation of mast cell proliferation", "down-regulation of mast cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of mast cell proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of mast cell proliferation. [GOC:add, GOC:mah]"}
{"concept_id": "C2753422", "aliases": ["up regulation of mast cell proliferation", "upregulation of mast cell proliferation", "stimulation of mast cell proliferation", "activation of mast cell proliferation", "up-regulation of mast cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of mast cell proliferation", "definition": "Any process that activates or increases the rate or extent of mast cell proliferation. [GOC:add, GOC:mah]"}
{"concept_id": "C2753423", "aliases": ["response to IL-2"], "types": ["T043"], "canonical_name": "response to interleukin-2", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus. [GOC:mah]"}
{"concept_id": "C2753424", "aliases": ["response to IL-4"], "types": ["T043"], "canonical_name": "response to interleukin-4", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. [GOC:mah]"}
{"concept_id": "C2753425", "aliases": ["response to IL-12"], "types": ["T043"], "canonical_name": "response to interleukin-12", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus. [GOC:mah]"}
{"concept_id": "C2753426", "aliases": ["response to IL-15"], "types": ["T043"], "canonical_name": "response to interleukin-15", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus. [GOC:mah]"}
{"concept_id": "C2753427", "aliases": ["response to IL-18"], "types": ["T043"], "canonical_name": "response to interleukin-18", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus. [GOC:mah]"}
{"concept_id": "C2753428", "aliases": ["hypoxanthine oxidoreductase activity", "hypoxanthine:NAD+ oxidoreductase activity", "hypoxanthine/NAD(+) oxidoreductase activity", "NAD-hypoxanthine dehydrogenase activity", "hypoxanthine-NAD oxidoreductase activity", "hypoxanthine/NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "hypoxanthine dehydrogenase activity", "definition": "Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+. [GOC:mah, GOC:pde]"}
{"concept_id": "C2753429", "aliases": ["xanthine oxidoreductase activity", "hypoxanthine:oxygen oxidoreductase activity", "hypoxanthine oxidase activity", "hypoxanthine:O2 oxidoreductase activity", "Schardinger enzyme activity", "hypoxanthine-xanthine oxidase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2. [GOC:mah, GOC:pde]", "canonical_name": "hypoxanthine:O(2) oxidoreductase activity"}
{"concept_id": "C2753430", "aliases": ["endosome membrane budding"], "types": ["T043"], "canonical_name": "intralumenal vesicle formation", "definition": "The invagination of the endosome membrane and resulting formation of a vesicle within the lumen of the endosome. [GOC:jp, PMID:19234443]"}
{"concept_id": "C2753431", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (cytosine-2'-O-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine. [GOC:mah, PMID:19400805]"}
{"concept_id": "C2753432", "aliases": ["unprocessed protein binding"], "types": ["T044"], "canonical_name": "preprotein binding", "definition": "Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing. [GOC:imk, GOC:mah, PMID:12914940]"}
{"concept_id": "C2753433", "aliases": ["IP3 binding", "InsP3 binding"], "types": ["T044"], "canonical_name": "inositol 1,4,5 trisphosphate binding", "definition": "Binding to inositol 1,4,5 trisphosphate. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753434", "aliases": [], "types": ["T045"], "canonical_name": "asparaginyl-tRNAAsn biosynthesis via transamidation", "definition": "A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase. [GOC:mah, MetaCyc:PWY490-4]"}
{"concept_id": "C2753435", "aliases": [], "types": ["T045"], "canonical_name": "glutaminyl-tRNAGln biosynthesis via transamidation", "definition": "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase. [GOC:mah, MetaCyc:PWY-5921]"}
{"concept_id": "C2753436", "aliases": ["proteasome regulatory complex assembly"], "types": ["T044"], "canonical_name": "proteasome regulatory particle assembly", "definition": "The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex. [GOC:mah, GOC:rb, PMID:19412159]"}
{"concept_id": "C2753437", "aliases": ["intracellular signal transduction involved in mitotic cell cycle G2/M transition decatenation checkpoint", "intracellular signaling pathway involved in mitotic DNA integrity checkpoint", "intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint", "intracellular signal transduction pathway involved in mitotic DNA integrity checkpoint", "intracellular signaling cascade involved in topo II checkpoint", "mitotic cell cycle G2/M transition decatenation checkpoint", "signal transduction involved in mitotic DNA integrity checkpoint", "intracellular signaling cascade involved in mitotic DNA integrity checkpoint", "intracellular signaling chain involved in mitotic DNA integrity checkpoint", "intracellular signal transduction involved in topo II checkpoint", "mitotic DNA integrity checkpoint", "intracellular signaling chain involved in mitotic cell cycle G2/M transition decatenation checkpoint"], "types": ["T043"], "canonical_name": "mitotic DNA integrity checkpoint signaling", "definition": "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. [GOC:mtg_cell_cycle]"}
{"concept_id": "C2753438", "aliases": ["semen liquefaction"], "types": ["T039"], "definition": "The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa. [GOC:mah, PMID:18482984]", "canonical_name": "seminal clot liquefaction"}
{"concept_id": "C2753439", "aliases": ["crown membrane"], "types": ["T026"], "canonical_name": "macropinocytic cup membrane", "definition": "The portion of the plasma membrane surrounding a macropinocytic cup. [GOC:mah]"}
{"concept_id": "C2753440", "aliases": ["crown cytoskeleton"], "types": ["T026"], "canonical_name": "macropinocytic cup cytoskeleton", "definition": "The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup. [GOC:mah]"}
{"concept_id": "C2753442", "aliases": [], "types": ["T044"], "canonical_name": "threonine catabolic process to propionate"}
{"concept_id": "C2753443", "aliases": [], "types": ["T044"], "canonical_name": "threonine catabolic process to acetyl-CoA"}
{"concept_id": "C2753444", "aliases": ["dimeric positive transcription elongation factor complex location b"], "types": ["T026"], "canonical_name": "dimeric positive transcription elongation factor complex b"}
{"concept_id": "C2753445", "aliases": ["Bur1/Bur2 complex location"], "types": ["T026"], "canonical_name": "Bur1/Bur2 complex"}
{"concept_id": "C2753446", "aliases": ["Sgv1/Bur2 complex location"], "types": ["T026"], "canonical_name": "Sgv1/Bur2 complex"}
{"concept_id": "C2753447", "aliases": ["trimeric positive transcription elongation factor complex location b"], "types": ["T026"], "canonical_name": "trimeric positive transcription elongation factor complex b"}
{"concept_id": "C2753448", "aliases": ["CTDK-1 complex location", "C-terminal domain kinase I complex location", "CTDK-I complex location", "CTDK-I complex", "Ctk complex location", "C-terminal domain kinase I complex", "Ctk complex"], "types": ["T026"], "canonical_name": "CTDK-1 complex", "definition": "A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638). [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067]"}
{"concept_id": "C2753450", "aliases": ["P-TEFb-Pcm1 complex", "P-TEFb-cap methyltransferase complex location", "P-TEFb-Pcm1 complex location"], "types": ["T026"], "canonical_name": "P-TEFb-cap methyltransferase complex", "definition": "A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase. [PMID:17332744, PMID:19328067]"}
{"concept_id": "C2753451", "aliases": ["Cdk9-Pcm1 complex location"], "types": ["T026"], "canonical_name": "Cdk9-Pcm1 complex"}
{"concept_id": "C2753452", "aliases": ["deoxynucleoside 5'-monophosphate N-glycosidase activity"], "types": ["T044"], "canonical_name": "deoxyribonucleoside 5'-monophosphate N-glycosidase activity", "definition": "Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base. [GOC:ab, PMID:17234634]"}
{"concept_id": "C2753453", "aliases": ["FHF complex location"], "types": ["T026"], "canonical_name": "FHF complex", "definition": "A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex). [GOC:ab, GOC:mah, PMID:18799622]"}
{"concept_id": "C2753454", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane receptor protein serine/threonine kinase binding", "definition": "Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753455", "aliases": [], "types": ["T044"], "canonical_name": "activin receptor binding", "definition": "Binding to an activin receptor. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2753456", "aliases": [], "types": ["T044"], "canonical_name": "type I activin receptor binding", "definition": "Binding to a type I activin receptor. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2753457", "aliases": [], "types": ["T044"], "canonical_name": "type II activin receptor binding", "definition": "Binding to a type II activin receptor. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2753458", "aliases": ["bone morphogenetic protein receptor binding"], "types": ["T044"], "canonical_name": "BMP receptor binding", "definition": "Binding to a BMP receptor. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2753459", "aliases": ["mucous", "mucus layer", "mucus"], "types": ["T031"], "definition": "An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. [GOC:krc, GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394, Wikipedia:Mucin]", "canonical_name": "mucous layer"}
{"concept_id": "C2753460", "aliases": [], "types": ["T026"], "canonical_name": "inner mucus layer", "definition": "The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria. [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394]"}
{"concept_id": "C2753461", "aliases": [], "types": ["T026"], "canonical_name": "outer mucus layer", "definition": "The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria. [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394]"}
{"concept_id": "C2753462", "aliases": [], "types": ["T044"], "canonical_name": "sterol desaturase activity", "definition": "Catalysis of the introduction of a double bond into a sterol molecule. [GOC:mah, GOC:vw]"}
{"concept_id": "C2753463", "aliases": [], "types": ["T045"], "canonical_name": "RNA nucleotide insertion", "definition": "The modification of an RNA molecule by insertion of one or more nucleotides. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753464", "aliases": ["RNA nucleotide excision"], "types": ["T045"], "canonical_name": "RNA nucleotide deletion", "definition": "The modification of an RNA molecule by removal of a single nucleotide. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753465", "aliases": [], "types": ["T045"], "canonical_name": "RNA dinucleotide insertion", "definition": "The modification of an RNA molecule by insertion of a dinucleotide. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753466", "aliases": ["RNA C insertion"], "types": ["T045"], "canonical_name": "RNA cytidine insertion", "definition": "The modification of an RNA molecule by insertion of a cytidine nucleotide. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753467", "aliases": ["RNA G insertion"], "types": ["T045"], "canonical_name": "RNA guanosine insertion", "definition": "The modification of an RNA molecule by insertion of a guanosine nucleotide. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753468", "aliases": ["RNA uridine excision", "RNA U deletion"], "types": ["T045"], "canonical_name": "RNA uridine deletion", "definition": "The modification of an RNA molecule by removal of a uridine nucleotide. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753469", "aliases": ["RNA AU insertion"], "types": ["T045"], "canonical_name": "RNA adenosine-uridine insertion", "definition": "The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753470", "aliases": ["RNA CU insertion"], "types": ["T045"], "canonical_name": "RNA cytidine-uridine insertion", "definition": "The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753471", "aliases": ["RNA GC insertion"], "types": ["T045"], "canonical_name": "RNA guanosine-cytidine insertion", "definition": "The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753472", "aliases": ["RNA GU insertion"], "types": ["T045"], "canonical_name": "RNA guanosine-uridine insertion", "definition": "The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide. [GOC:cb, GOC:mah]"}
{"concept_id": "C2753473", "aliases": [], "types": ["T043"], "canonical_name": "sodium-dependent organic cation transport", "definition": "The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753474", "aliases": [], "types": ["T045"], "canonical_name": "mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication"}
{"concept_id": "C2753475", "aliases": [], "types": ["T045"], "canonical_name": "poly-purine tract binding", "definition": "Binding to a stretch of purines (adenine or guanine) in an RNA molecule. [GOC:mah]"}
{"concept_id": "C2753476", "aliases": ["PDGFRA-SHP-2 complex, PDGF stimulated", "alphaPDGFR-SHP-2 complex location", "PDGFRA-SHP-2 complex location, PDGF stimulated"], "types": ["T026"], "canonical_name": "alphaPDGFR-SHP-2 complex", "definition": "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway. [GOC:mah, PMID:8943348]"}
{"concept_id": "C2753477", "aliases": ["PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex location, PDGF stimulated", "PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated", "alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex location"], "types": ["T026"], "canonical_name": "alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex", "definition": "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway. [GOC:mah, PMID:8943348]"}
{"concept_id": "C2753478", "aliases": ["GRB2-SHP-2 complex, PDGF stimulated", "GRB2-SHP-2 complex location, PDGF stimulated", "Grb2-SHP-2 complex location"], "types": ["T026"], "canonical_name": "Grb2-SHP-2 complex", "definition": "A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway. [GOC:mah, PMID:8943348]"}
{"concept_id": "C2753479", "aliases": ["interferon-stimulated gene factor 3 transcription complex location", "ISGF3 complex location", "interferon-stimulated gene factor 3 transcription complex"], "types": ["T026"], "canonical_name": "ISGF3 complex", "definition": "A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein. [GOC:mah, PMID:8943351]"}
{"concept_id": "C2753480", "aliases": ["Tle3-Aes complex location", "Grg3b-Grg5 complex", "Grg3b-Grg5 complex location"], "types": ["T026"], "canonical_name": "Tle3-Aes complex", "definition": "A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product. [GOC:mah, PMID:8955148]"}
{"concept_id": "C2753481", "aliases": [], "types": ["T043"], "canonical_name": "response to cholesterol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. [GOC:BHF, GOC:vk]"}
{"concept_id": "C2753482", "aliases": ["bone morphogenetic protein receptor complex", "bone morphogenetic protein receptor complex location", "BMP receptor complex location"], "types": ["T026"], "canonical_name": "BMP receptor complex", "definition": "A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits. [GOC:mah, GOC:mh, PMID:19377468]"}
{"concept_id": "C2753483", "aliases": [], "types": ["T026"], "canonical_name": "Yb body", "definition": "A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell. [GOC:sart, PMID:19433453]"}
{"concept_id": "C2753484", "aliases": ["cellular macromolecule localisation"], "types": ["T043"], "canonical_name": "cellular macromolecule localization", "definition": "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. [GOC:mah]"}
{"concept_id": "C2753485", "aliases": ["Leu binding"], "types": ["T044"], "canonical_name": "leucine binding", "definition": "Binding to 2-amino-4-methylpentanoic acid. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753486", "aliases": [], "types": ["T043"], "canonical_name": "cyclic nucleotide transport", "definition": "The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2753487", "aliases": ["cyclic AMP transport"], "types": ["T043"], "canonical_name": "cAMP transport", "definition": "The directed movement of cyclic AMP (cAMP), into, out of or within a cell. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2753488", "aliases": ["cyclic GMP transport"], "types": ["T043"], "canonical_name": "cGMP transport", "definition": "The directed movement of cyclic GMP (cGMP), into, out of or within a cell. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C2753489", "aliases": [], "types": ["T026"], "canonical_name": "spindle envelope", "definition": "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase. [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889]"}
{"concept_id": "C2753490", "aliases": ["AMPylator", "adenosine monophosphate-protein transferase activity"], "types": ["T044"], "canonical_name": "protein adenylyltransferase activity", "definition": "Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins. [GOC:mah, PMID:19039103, PMID:19362538]"}
{"concept_id": "C2753491", "aliases": ["histone lysine H3 K27 methylation", "histone H3K27me", "histone H3 K27 methylation"], "types": ["T044"], "canonical_name": "histone H3-K27 methylation", "definition": "The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone. [GOC:mah, GOC:pr]"}
{"concept_id": "C2753492", "aliases": ["protein glycylase activity"], "types": ["T044"], "canonical_name": "protein-glycine ligase activity", "definition": "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein. [GOC:mah, PMID:19524510]"}
{"concept_id": "C2753493", "aliases": ["protein glycylase activity, initiating"], "types": ["T044"], "canonical_name": "protein-glycine ligase activity, initiating", "definition": "Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein. [GOC:mah, PMID:19524510]"}
{"concept_id": "C2753494", "aliases": ["protein glycylase activity, elongating"], "types": ["T044"], "canonical_name": "protein-glycine ligase activity, elongating", "definition": "Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain. [GOC:mah, PMID:19524510]"}
{"concept_id": "C2753495", "aliases": ["tubulin glycylase activity"], "types": ["T044"], "canonical_name": "tubulin-glycine ligase activity", "definition": "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin. [GOC:mah, PMID:19524510]"}
{"concept_id": "C2753496", "aliases": ["protein-glutamate ligase activity", "protein glutamylase activity"], "types": ["T044"], "canonical_name": "protein-glutamic acid ligase activity", "definition": "Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein. [GOC:mah, PMID:19524510]"}
{"concept_id": "C2753497", "aliases": ["tubulin-glutamate ligase activity", "tubulin glutamylase activity"], "types": ["T044"], "canonical_name": "tubulin-glutamic acid ligase activity", "definition": "Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule. [GOC:mah, PMID:19524510]"}
{"concept_id": "C2753498", "aliases": ["response to IL-6"], "types": ["T043"], "canonical_name": "response to interleukin-6", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. [GOC:mah]"}
{"concept_id": "C2753499", "aliases": [], "types": ["T044"], "canonical_name": "C2H2 zinc finger domain binding", "definition": "Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. [GOC:BHF, GOC:mah, Pfam:PF00096]"}
{"concept_id": "C2753500", "aliases": ["p40", "IL23A", "IL-23 complex", "IL-23 complex location", "interleukin-23 complex", "interleukin-23 complex location", "IL12B"], "types": ["T026"], "definition": "A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space. [GOC:add, PMID:11114383, PMID:15999093]", "canonical_name": "p19"}
{"concept_id": "C2753501", "aliases": ["EBI3", "interleukin-27 complex", "p28", "IL-27 complex", "interleukin-27 complex location", "IL27"], "types": ["T026"], "definition": "A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space. [GOC:add, PMID:15999093, PMID:19161428]", "canonical_name": "IL-27 complex location"}
{"concept_id": "C2753502", "aliases": ["IL-35 binding"], "types": ["T044"], "canonical_name": "interleukin-35 binding", "definition": "Binding to interleukin-35. [GOC:add]"}
{"concept_id": "C2753503", "aliases": ["IL-35R", "IL-35 receptor activity"], "types": ["T044"], "canonical_name": "interleukin-35 receptor activity", "definition": "Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling]"}
{"concept_id": "C2753504", "aliases": ["IL-35", "interleukin-35 receptor binding"], "types": ["T044"], "definition": "Binding to an interleukin-35 receptor. [GOC:add]", "canonical_name": "interleukin-35 receptor ligand"}
{"concept_id": "C2753512", "aliases": ["IL-35 production"], "types": ["T040"], "canonical_name": "interleukin-35 production", "definition": "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]"}
{"concept_id": "C2753513", "aliases": ["regulation of IL-35 production"], "types": ["T044"], "canonical_name": "regulation of interleukin-35 production", "definition": "Any process that modulates the frequency, rate, or extent of interleukin-35 production. [GOC:mah]"}
{"concept_id": "C2753514", "aliases": ["down-regulation of interleukin-35 production", "negative regulation of IL-35 production", "downregulation of interleukin-35 production", "down regulation of interleukin-35 production"], "types": ["T044"], "canonical_name": "negative regulation of interleukin-35 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production. [GOC:mah]"}
{"concept_id": "C2753515", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of interleukin-35 production"}
{"concept_id": "C2753516", "aliases": ["upregulation of interleukin-35 production", "positive regulation of IL-35 production", "up regulation of interleukin-35 production", "up-regulation of interleukin-35 production"], "types": ["T044"], "canonical_name": "positive regulation of interleukin-35 production", "definition": "Any process that activates or increases the frequency, rate, or extent of interleukin-35 production. [GOC:mah]"}
{"concept_id": "C2753517", "aliases": [], "types": ["T044"], "canonical_name": "activation of interleukin-35 production"}
{"concept_id": "C2753518", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of interleukin-35 production"}
{"concept_id": "C2753519", "aliases": ["IL-35-mediated signaling pathway", "interleukin-35-mediated signalling pathway"], "types": ["T043"], "canonical_name": "interleukin-35-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-35 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:add, GOC:mah, GOC:signaling]"}
{"concept_id": "C2753520", "aliases": ["regulation of interleukin-35-mediated signalling pathway", "regulation of IL-35-mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of interleukin-35-mediated signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of an interleukin-35-mediated signaling pathway. [GOC:mah]"}
{"concept_id": "C2753521", "aliases": ["negative regulation of interleukin-35-mediated signalling pathway", "negative regulation of IL-35-mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of interleukin-35-mediated signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of an interleukin-35-mediated signaling pathway. [GOC:mah]"}
{"concept_id": "C2753522", "aliases": ["positive regulation of interleukin-35-mediated signalling pathway", "positive regulation of IL-35-mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of interleukin-35-mediated signaling pathway", "definition": "Any process that increases the rate, frequency or extent of an interleukin-35-mediated signaling pathway. [GOC:mah]"}
{"concept_id": "C2753523", "aliases": [], "types": ["T038"], "canonical_name": "respiratory burst involved in defense response", "definition": "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:add, ISBN:0781735149, PMID:12789499]"}
{"concept_id": "C2753524", "aliases": ["immune response-regulating signalling pathway"], "types": ["T040"], "canonical_name": "immune response-regulating signaling pathway", "definition": "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]"}
{"concept_id": "C2753525", "aliases": [], "types": ["T043"], "canonical_name": "detection of nodal flow", "definition": "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry. [GOC:mtg_heart]"}
{"concept_id": "C2753526", "aliases": [], "types": ["T042"], "canonical_name": "heart field specification", "definition": "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop. [GOC:mtg_heart]"}
{"concept_id": "C2753527", "aliases": [], "types": ["T042"], "canonical_name": "heart induction", "definition": "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753528", "aliases": ["BMP signalling pathway involved in heart induction"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in heart induction", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction. [GOC:mtg_heart]"}
{"concept_id": "C2753529", "aliases": ["mesodermal-endodermal cell signalling"], "types": ["T043"], "definition": "Any process that mediates the transfer of information from mesodermal cells to endodermal cells. [GOC:mtg_heart]", "canonical_name": "mesodermal-endodermal cell signaling"}
{"concept_id": "C2753530", "aliases": ["mesodermal-endodermal cell signalling involved in heart induction"], "types": ["T043"], "definition": "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction. [GOC:mtg_heart]", "canonical_name": "mesodermal-endodermal cell signaling involved in heart induction"}
{"concept_id": "C2753531", "aliases": ["endodermal-mesodermal cell signalling"], "types": ["T043"], "definition": "Any process that mediates the transfer of information from endodermal cells to mesodermal cells. [GOC:mtg_heart]", "canonical_name": "endodermal-mesodermal cell signaling"}
{"concept_id": "C2753532", "aliases": ["endodermal-mesodermal cell signalling involved in heart induction"], "types": ["T043"], "definition": "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction. [GOC:mtg_heart]", "canonical_name": "endodermal-mesodermal cell signaling involved in heart induction"}
{"concept_id": "C2753533", "aliases": ["fibroblast growth factor receptor signalling pathway involved in heart induction"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in heart induction", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction. [GOC:mtg_heart]"}
{"concept_id": "C2753534", "aliases": ["negative regulation of heart induction by canonical Wnt receptor signaling pathway", "negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway", "negative regulation of heart induction by canonical Wnt receptor signalling pathway", "negative regulation of heart induction by canonical Wnt-activated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of heart induction by canonical Wnt signaling pathway", "definition": "Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction. [GOC:mtg_heart, PMID:19862329]"}
{"concept_id": "C2753535", "aliases": ["Notch signalling pathway involved in heart induction"], "types": ["T044"], "canonical_name": "Notch signaling pathway involved in heart induction", "definition": "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction. [GOC:mtg_heart]"}
{"concept_id": "C2753536", "aliases": ["first heart field specification", "FHS specification"], "types": ["T042"], "canonical_name": "primary heart field specification", "definition": "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. [GOC:mtg_heart, GOC:rl]"}
{"concept_id": "C2753537", "aliases": ["SHF specification", "second heart field specification"], "types": ["T042"], "canonical_name": "secondary heart field specification", "definition": "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract). [GOC:mtg_heart, GOC:rl, PMID:17276708]"}
{"concept_id": "C2753538", "aliases": [], "types": ["T042"], "canonical_name": "anterior heart field specification"}
{"concept_id": "C2753539", "aliases": [], "types": ["T040"], "canonical_name": "determination of left/right asymmetry in lateral mesoderm", "definition": "The establishment of the lateral mesoderm with respect to the left and right halves. [GOC:mtg_heart]"}
{"concept_id": "C2753541", "aliases": ["cardiac crescent morphogenesis"], "types": ["T040"], "canonical_name": "cardiogenic plate morphogenesis", "definition": "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. [GOC:mtg_heart]"}
{"concept_id": "C2753542", "aliases": [], "types": ["T040"], "canonical_name": "embryonic heart tube morphogenesis", "definition": "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. [GOC:mtg_heart]"}
{"concept_id": "C2753543", "aliases": [], "types": ["T042"], "canonical_name": "embryonic heart tube formation", "definition": "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. [GOC:mtg_heart]"}
{"concept_id": "C2753544", "aliases": [], "types": ["T042"], "canonical_name": "embryonic heart tube formation via epithelial folding", "definition": "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. [GOC:mtg_heart]"}
{"concept_id": "C2753545", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell migration involved in heart formation", "definition": "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation. [GOC:mtg_heart]"}
{"concept_id": "C2753546", "aliases": [], "types": ["T040"], "canonical_name": "outflow tract septum morphogenesis", "definition": "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. [GOC:mtg_heart]"}
{"concept_id": "C2753547", "aliases": [], "types": ["T040"], "canonical_name": "membranous septum morphogenesis", "definition": "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. [GOC:mtg_heart]"}
{"concept_id": "C2753548", "aliases": [], "types": ["T040"], "canonical_name": "muscular septum morphogenesis", "definition": "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. [GOC:mtg_heart]"}
{"concept_id": "C2753549", "aliases": [], "types": ["T040"], "canonical_name": "outflow tract morphogenesis", "definition": "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. [GOC:mtg_heart, UBERON:0004145]"}
{"concept_id": "C2753550", "aliases": [], "types": ["T040"], "canonical_name": "morphogenesis of an epithelial fold involved in embryonic heart tube formation", "definition": "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. [GOC:mtg_heart]"}
{"concept_id": "C2753551", "aliases": [], "types": ["T042"], "canonical_name": "closure of embryonic heart tube", "definition": "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold. [GOC:mtg_heart]"}
{"concept_id": "C2753552", "aliases": ["BMP signaling pathway involved in determination of left/right asymmetry", "BMP signalling pathway involved in determination of left/right symmetry"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in determination of left/right symmetry", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry. [GOC:mtg_heart, GOC:signaling]"}
{"concept_id": "C2753553", "aliases": ["BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "definition": "The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry. [GOC:mtg_heart]"}
{"concept_id": "C2753554", "aliases": [], "types": ["T038"], "canonical_name": "regulation of animal organ formation", "definition": "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. [GOC:dph, GOC:mtg_heart, GOC:tb]"}
{"concept_id": "C2753555", "aliases": [], "types": ["T042"], "canonical_name": "endocardium development", "definition": "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:mtg_heart]"}
{"concept_id": "C2753556", "aliases": [], "types": ["T042"], "canonical_name": "endothelium development", "definition": "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. [GOC:mtg_heart]"}
{"concept_id": "C2753557", "aliases": [], "types": ["T042"], "canonical_name": "morphogenesis of an endothelium", "definition": "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. [GOC:mtg_heart]"}
{"concept_id": "C2753558", "aliases": [], "types": ["T042"], "canonical_name": "endocardium morphogenesis", "definition": "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:mtg_heart]"}
{"concept_id": "C2753559", "aliases": ["cardiac impulse conducting system development", "heart conduction system development"], "types": ["T042"], "canonical_name": "cardiac conduction system development", "definition": "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. [GOC:mtg_heart]"}
{"concept_id": "C2753560", "aliases": ["AV node development"], "types": ["T042"], "canonical_name": "atrioventricular node development", "definition": "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. [GOC:mtg_heart]"}
{"concept_id": "C2753561", "aliases": ["SAN development", "SA node development"], "types": ["T042"], "canonical_name": "sinoatrial node development", "definition": "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. [GOC:mtg_heart]"}
{"concept_id": "C2753562", "aliases": [], "types": ["T042"], "canonical_name": "His-Purkinje system development", "definition": "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. [GOC:mtg_heart]"}
{"concept_id": "C2753563", "aliases": ["cardiac Purkinje fiber development"], "types": ["T042"], "canonical_name": "Purkinje myocyte development", "definition": "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]"}
{"concept_id": "C2753564", "aliases": ["atrioventricular bundle development"], "types": ["T042"], "canonical_name": "bundle of His development", "definition": "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers. [GOC:mtg_heart]"}
{"concept_id": "C2753565", "aliases": ["AV bundle cell differentiation"], "types": ["T043"], "canonical_name": "atrioventricular bundle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers. [GOC:mtg_heart]"}
{"concept_id": "C2753566", "aliases": ["cardiac Purkinje fiber cell differentiation"], "types": ["T043"], "canonical_name": "Purkinje myocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]"}
{"concept_id": "C2753567", "aliases": [], "types": ["T042"], "canonical_name": "coronary vein morphogenesis", "definition": "The process in which the anatomical structures of veins of the heart are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753568", "aliases": ["cardiac valve development"], "types": ["T042"], "canonical_name": "heart valve development", "definition": "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. [GOC:mtg_heart]"}
{"concept_id": "C2753569", "aliases": ["AV valve development"], "types": ["T042"], "canonical_name": "atrioventricular valve development", "definition": "The progression of the atrioventricular valve over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753570", "aliases": ["SA valve development"], "types": ["T042"], "canonical_name": "sinoatrial valve development", "definition": "The progression of the sinoatrial valve over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753571", "aliases": [], "types": ["T042"], "canonical_name": "ventriculo bulbo valve development", "definition": "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753572", "aliases": [], "types": ["T042"], "canonical_name": "mitral valve development", "definition": "The progression of the mitral valve over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753573", "aliases": [], "types": ["T042"], "canonical_name": "tricuspid valve development", "definition": "The progression of the tricuspid valve over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753574", "aliases": [], "types": ["T042"], "canonical_name": "aortic valve development", "definition": "The progression of the aortic valve over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753575", "aliases": [], "types": ["T042"], "canonical_name": "pulmonary valve development", "definition": "The progression of the pulmonary valve over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753576", "aliases": [], "types": ["T042"], "canonical_name": "coronary sinus valve development", "definition": "The progression of the valve of the coronary sinus over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753577", "aliases": [], "types": ["T040"], "canonical_name": "heart valve morphogenesis", "definition": "The process in which the structure of a heart valve is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753578", "aliases": [], "types": ["T040"], "canonical_name": "aortic valve morphogenesis", "definition": "The process in which the structure of the aortic valve is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753579", "aliases": ["AV valve morphogenesis"], "types": ["T040"], "canonical_name": "atrioventricular valve morphogenesis", "definition": "The process in which the structure of the atrioventricular valve is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753580", "aliases": [], "types": ["T040"], "canonical_name": "coronary sinus valve morphogenesis", "definition": "The process in which the structure of the coronary sinus valve is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753581", "aliases": [], "types": ["T040"], "canonical_name": "mitral valve morphogenesis", "definition": "The process in which the structure of the mitral valve is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753582", "aliases": [], "types": ["T040"], "canonical_name": "pulmonary valve morphogenesis", "definition": "The process in which the structure of the pulmonary valve is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753583", "aliases": ["SA valve morphogenesis"], "types": ["T040"], "canonical_name": "sinoatrial valve morphogenesis", "definition": "The process in which the structure of the sinoatrial valve is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753584", "aliases": [], "types": ["T040"], "canonical_name": "tricuspid valve morphogenesis", "definition": "The process in which the structure of the tricuspid valve is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753585", "aliases": [], "types": ["T040"], "canonical_name": "ventriculo bulbo valve morphogenesis", "definition": "The process in which the structure of the ventriculo bulbo valve is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753586", "aliases": [], "types": ["T042"], "canonical_name": "heart valve formation", "definition": "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]"}
{"concept_id": "C2753587", "aliases": [], "types": ["T042"], "canonical_name": "aortic valve formation", "definition": "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]"}
{"concept_id": "C2753588", "aliases": ["AV valve formation"], "types": ["T042"], "canonical_name": "atrioventricular valve formation", "definition": "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]"}
{"concept_id": "C2753589", "aliases": [], "types": ["T042"], "canonical_name": "coronary sinus valve formation", "definition": "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]"}
{"concept_id": "C2753590", "aliases": [], "types": ["T042"], "canonical_name": "mitral valve formation", "definition": "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]"}
{"concept_id": "C2753591", "aliases": [], "types": ["T042"], "canonical_name": "pulmonary valve formation", "definition": "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]"}
{"concept_id": "C2753592", "aliases": ["SA valve formation"], "types": ["T042"], "canonical_name": "sinoatrial valve formation", "definition": "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]"}
{"concept_id": "C2753593", "aliases": [], "types": ["T042"], "canonical_name": "tricuspid valve formation", "definition": "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]"}
{"concept_id": "C2753594", "aliases": [], "types": ["T042"], "canonical_name": "ventriculo bulbo valve formation", "definition": "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]"}
{"concept_id": "C2753595", "aliases": [], "types": ["T042"], "canonical_name": "endocardial cushion development", "definition": "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. [GOC:mtg_heart]"}
{"concept_id": "C2753596", "aliases": [], "types": ["T043"], "canonical_name": "epithelial to mesenchymal transition involved in endocardial cushion formation", "definition": "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion. [GOC:mtg_heart]"}
{"concept_id": "C2753597", "aliases": ["endocardial cushion to mesenchymal transition involved in valve formation"], "types": ["T043"], "canonical_name": "endocardial cushion to mesenchymal transition involved in heart valve formation", "definition": "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve. [GOC:mtg_heart]"}
{"concept_id": "C2753598", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cushion to mesenchymal transition involved in heart chamber septation", "definition": "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum. [GOC:mtg_heart]"}
{"concept_id": "C2753599", "aliases": [], "types": ["T043"], "canonical_name": "epithelial to mesenchymal transition involved in coronary vasculature morphogenesis", "definition": "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature. [GOC:mtg_heart]"}
{"concept_id": "C2753600", "aliases": [], "types": ["T042"], "canonical_name": "endocardial cushion to mesenchymal transition involved in cardiac skeleton development", "definition": "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton. [GOC:mtg_heart]"}
{"concept_id": "C2753601", "aliases": [], "types": ["T042"], "canonical_name": "endocardial cushion morphogenesis", "definition": "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. [GOC:mtg_heart]"}
{"concept_id": "C2753602", "aliases": ["heart fibrous skeleton development"], "types": ["T042"], "canonical_name": "cardiac skeleton development", "definition": "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753603", "aliases": [], "types": ["T042"], "canonical_name": "cardiac chamber development", "definition": "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753604", "aliases": ["heart chamber morphogenesis"], "types": ["T040"], "canonical_name": "cardiac chamber morphogenesis", "definition": "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753605", "aliases": ["heart chamber formation"], "types": ["T042"], "canonical_name": "cardiac chamber formation", "definition": "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753606", "aliases": [], "types": ["T040"], "canonical_name": "cardiac ventricle morphogenesis", "definition": "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753607", "aliases": [], "types": ["T040"], "canonical_name": "cardiac atrium morphogenesis", "definition": "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. [GOC:mtg_heart]"}
{"concept_id": "C2753608", "aliases": [], "types": ["T042"], "canonical_name": "cardiac atrium formation", "definition": "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. [GOC:mtg_heart]"}
{"concept_id": "C2753609", "aliases": [], "types": ["T042"], "canonical_name": "cardiac ventricle formation", "definition": "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753610", "aliases": [], "types": ["T040"], "canonical_name": "cardiac left atrium morphogenesis", "definition": "The process in which the left cardiac atrium is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753611", "aliases": [], "types": ["T040"], "canonical_name": "cardiac right atrium morphogenesis", "definition": "The process in which the right cardiac atrium is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753612", "aliases": [], "types": ["T040"], "canonical_name": "cardiac left ventricle morphogenesis", "definition": "The process in which the left cardiac ventricle is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753613", "aliases": [], "types": ["T040"], "canonical_name": "cardiac right ventricle morphogenesis", "definition": "The process in which the right cardiac ventricle is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753614", "aliases": [], "types": ["T042"], "canonical_name": "cardiac left atrium formation", "definition": "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. [GOC:mtg_heart]"}
{"concept_id": "C2753615", "aliases": [], "types": ["T042"], "canonical_name": "cardiac right atrium formation", "definition": "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. [GOC:mtg_heart]"}
{"concept_id": "C2753616", "aliases": [], "types": ["T042"], "canonical_name": "cardiac left ventricle formation", "definition": "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. [GOC:mtg_heart]"}
{"concept_id": "C2753617", "aliases": [], "types": ["T042"], "canonical_name": "cardiac right ventricle formation", "definition": "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. [GOC:mtg_heart]"}
{"concept_id": "C2753618", "aliases": ["left ventricular myocardium morphogenesis"], "types": ["T042"], "canonical_name": "left ventricular cardiac muscle tissue morphogenesis", "definition": "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753619", "aliases": ["right ventricle myocardium morphogenesis"], "types": ["T042"], "canonical_name": "right ventricular cardiac muscle tissue morphogenesis", "definition": "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753620", "aliases": [], "types": ["T042"], "canonical_name": "ventricular trabecula myocardium morphogenesis", "definition": "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753621", "aliases": [], "types": ["T042"], "canonical_name": "ventricular compact myocardium morphogenesis", "definition": "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753622", "aliases": [], "types": ["T042"], "canonical_name": "left ventricular compact myocardium morphogenesis", "definition": "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753623", "aliases": [], "types": ["T042"], "canonical_name": "left ventricular trabecular myocardium morphogenesis", "definition": "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753624", "aliases": [], "types": ["T042"], "canonical_name": "right ventricular compact myocardium morphogenesis", "definition": "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753625", "aliases": [], "types": ["T042"], "canonical_name": "right ventricular trabecular myocardium morphogenesis", "definition": "The process in which the anatomical structures of the right ventricular myocardium are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753626", "aliases": ["atrial myocardium development"], "types": ["T042"], "canonical_name": "atrial cardiac muscle tissue development", "definition": "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753627", "aliases": ["ventricular myocardium development"], "types": ["T042"], "canonical_name": "ventricular cardiac muscle tissue development", "definition": "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753628", "aliases": [], "types": ["T042"], "canonical_name": "cardiac atrium development", "definition": "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. [GOC:mtg_heart]"}
{"concept_id": "C2753629", "aliases": [], "types": ["T042"], "canonical_name": "cardiac ventricle development", "definition": "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753630", "aliases": [], "types": ["T042"], "canonical_name": "bulbus arteriosus development", "definition": "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber. [GOC:mtg_heart]"}
{"concept_id": "C2753631", "aliases": [], "types": ["T040"], "canonical_name": "bulbus arteriosus morphogenesis", "definition": "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber. [GOC:mtg_heart]"}
{"concept_id": "C2753632", "aliases": [], "types": ["T042"], "canonical_name": "bulbus arteriosus formation", "definition": "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753633", "aliases": [], "types": ["T042"], "canonical_name": "sinus venosus development", "definition": "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. [GOC:mtg_heart]"}
{"concept_id": "C2753634", "aliases": [], "types": ["T040"], "canonical_name": "sinus venosus morphogenesis", "definition": "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. [GOC:mtg_heart]"}
{"concept_id": "C2753635", "aliases": [], "types": ["T042"], "canonical_name": "sinus venosus formation", "definition": "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. [GOC:mtg_heart]"}
{"concept_id": "C2753636", "aliases": [], "types": ["T042"], "canonical_name": "conus arteriosus development", "definition": "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk. [GOC:mtg_heart]"}
{"concept_id": "C2753637", "aliases": [], "types": ["T040"], "canonical_name": "conus arteriosus morphogenesis", "definition": "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk. [GOC:mtg_heart]"}
{"concept_id": "C2753638", "aliases": [], "types": ["T042"], "canonical_name": "conus arteriosus formation", "definition": "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk. [GOC:mtg_heart]"}
{"concept_id": "C2753639", "aliases": [], "types": ["T040"], "canonical_name": "growth involved in heart morphogenesis", "definition": "Developmental growth that contributes to the shaping of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753640", "aliases": [], "types": ["T040"], "canonical_name": "cardiac chamber ballooning", "definition": "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping. [GOC:mtg_heart]"}
{"concept_id": "C2753641", "aliases": [], "types": ["T040"], "canonical_name": "circumferential growth involved in left ventricle morphogenesis", "definition": "The morphogenetic growth in which the left ventricle grows expanding its external boundary. [GOC:mtg_heart, PMID:14709543]"}
{"concept_id": "C2753642", "aliases": [], "types": ["T040"], "canonical_name": "radial growth involved in right ventricle morphogenesis", "definition": "The morphogenic growth in which the right ventricle grows along a radial axis. [GOC:mtg_heart]"}
{"concept_id": "C2753643", "aliases": [], "types": ["T040"], "canonical_name": "cardiac muscle tissue growth involved in heart morphogenesis", "definition": "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753644", "aliases": ["embryonic cardiac muscle physiological hypertrophy"], "types": ["T043"], "canonical_name": "embryonic cardiac muscle cell growth involved in heart morphogenesis", "definition": "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753645", "aliases": [], "types": ["T043"], "canonical_name": "post-embryonic cardiac muscle cell growth involved in heart morphogenesis", "definition": "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753646", "aliases": [], "types": ["T040"], "canonical_name": "heart capillary growth", "definition": "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. [GOC:mtg_heart]"}
{"concept_id": "C2753647", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in heart valve morphogenesis", "definition": "The multiplication or reproduction of cells that contributes to the shaping of a heart valve. [GOC:mtg_heart]"}
{"concept_id": "C2753648", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in heart valve morphogenesis", "definition": "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve. [GOC:mtg_heart]"}
{"concept_id": "C2753649", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell proliferation involved in heart valve morphogenesis", "definition": "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve. [GOC:mtg_heart]"}
{"concept_id": "C2753650", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell proliferation involved in heart valve morphogenesis", "definition": "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve. [GOC:mtg_heart]"}
{"concept_id": "C2753651", "aliases": [], "types": ["T043"], "canonical_name": "cardiac neural crest cell migration involved in outflow tract morphogenesis", "definition": "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. [GOC:mtg_heart]"}
{"concept_id": "C2753652", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane depolarization", "definition": "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753653", "aliases": [], "types": ["T043"], "canonical_name": "endocardial precursor cell differentiation", "definition": "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate. [GOC:mtg_heart]"}
{"concept_id": "C2753657", "aliases": [], "types": ["T043"], "canonical_name": "cardioblast anterior-lateral migration", "definition": "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753658", "aliases": [], "types": ["T043"], "canonical_name": "cardioblast migration", "definition": "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753659", "aliases": ["myocardial progenitor cell midline convergence"], "types": ["T043"], "canonical_name": "cardiac muscle progenitor cell migration to the midline involved in heart field formation", "definition": "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753660", "aliases": [], "types": ["T042"], "canonical_name": "endocardial progenitor cell migration to the midline involved in heart field formation", "definition": "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753661", "aliases": [], "types": ["T043"], "canonical_name": "cardioblast proliferation", "definition": "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753662", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardioblast proliferation", "definition": "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753663", "aliases": ["regulation of first heart field cardioblast proliferation", "regulation of FHF cardioblast proliferation", "regulation of first heart field cardiac proliferation"], "types": ["T043"], "canonical_name": "regulation of primary heart field cardioblast proliferation", "definition": "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle. [GOC:mtg_heart, GOC:rl]"}
{"concept_id": "C2753664", "aliases": ["regulation of SHF cardioblast proliferation", "regulation of second heart field cardioblast proliferation"], "types": ["T043"], "canonical_name": "regulation of secondary heart field cardioblast proliferation", "definition": "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract). [GOC:mtg_heart, GOC:rl, PMID:17276708]"}
{"concept_id": "C2753665", "aliases": ["canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation", "canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation", "canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation", "definition": "A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753666", "aliases": ["fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation", "fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation", "fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753667", "aliases": ["BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation", "BMP signaling pathway involved in regulation of second heart field cardioblast proliferation"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753668", "aliases": ["Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation", "Notch signaling pathway involved in regulation of second heart field cardioblast proliferation"], "types": ["T044"], "canonical_name": "Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation", "definition": "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753669", "aliases": ["hh signaling pathway involved in regulation of second heart field cardioblast proliferation", "smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation", "hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation", "smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation", "smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation"], "types": ["T044"], "canonical_name": "smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation", "definition": "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]"}
{"concept_id": "C2753670", "aliases": [], "types": ["T042"], "canonical_name": "endocardial cushion formation", "definition": "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. [GOC:mtg_heart, PMID:15797462]"}
{"concept_id": "C2753671", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in endocardial cushion formation", "definition": "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. [GOC:mtg_heart]"}
{"concept_id": "C2753672", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cushion fusion", "definition": "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping. [GOC:mtg_heart]"}
{"concept_id": "C2753673", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C2753674", "aliases": ["apoptosis involved in heart valve morphogenesis"], "types": ["T043"], "canonical_name": "apoptotic process involved in heart valve morphogenesis", "definition": "Any apoptotic process that contributes to the shaping of a heart valve. [GOC:mtg_apoptosis, GOC:mtg_heart]"}
{"concept_id": "C2753675", "aliases": ["apoptosis involved in endocardial cushion morphogenesis"], "types": ["T043"], "canonical_name": "apoptotic process involved in endocardial cushion morphogenesis", "definition": "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. [GOC:mtg_apoptosis, GOC:mtg_heart]"}
{"concept_id": "C2753676", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in heart morphogenesis"}
{"concept_id": "C2753677", "aliases": ["heart septum development"], "types": ["T042"], "canonical_name": "cardiac septum development", "definition": "The progression of a cardiac septum over time, from its initial formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753678", "aliases": ["interventricular septum development", "septum inferius development"], "types": ["T042"], "canonical_name": "ventricular septum development", "definition": "The progression of the ventricular septum over time from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753679", "aliases": [], "types": ["T042"], "canonical_name": "ventricular septum intermedium development", "definition": "The progression of the ventricular septum intermedium over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753680", "aliases": [], "types": ["T042"], "canonical_name": "atrial septum development", "definition": "The progression of the atrial septum over time, from its initial formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753681", "aliases": [], "types": ["T042"], "canonical_name": "septum primum development", "definition": "The progression of the septum primum over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753682", "aliases": [], "types": ["T042"], "canonical_name": "septum secundum development", "definition": "The progression of the septum secundum over time, from its initial formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753683", "aliases": [], "types": ["T042"], "canonical_name": "atrial septum intermedium development", "definition": "The progression of the atrial septum intermedium over time, from its formation to the mature structure. [GOC:mtg_heart]"}
{"concept_id": "C2753684", "aliases": [], "types": ["T042"], "canonical_name": "ventricular septum intermedium morphogenesis", "definition": "The developmental process in which a ventricular septum intermedium is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753685", "aliases": [], "types": ["T042"], "canonical_name": "atrial septum primum morphogenesis", "definition": "The process in which anatomical structure of an atrial septum primum is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753686", "aliases": [], "types": ["T042"], "canonical_name": "atrial septum secundum morphogenesis", "definition": "The process in which anatomical structure of an atrial septum secundum is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753687", "aliases": [], "types": ["T042"], "canonical_name": "atrial septum intermedium morphogenesis", "definition": "The process in which anatomical structure of an atrial septum intermedium is generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753688", "aliases": [], "types": ["T043"], "canonical_name": "cardiac septum cell differentiation", "definition": "The process in which an endocardial cushion cell becomes a cell of a cardiac septum. [GOC:mtg_heart]"}
{"concept_id": "C2753689", "aliases": [], "types": ["T043"], "canonical_name": "heart valve cell differentiation", "definition": "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve. [GOC:mtg_heart]"}
{"concept_id": "C2753690", "aliases": ["atrio-ventricular junction remodeling", "atrioventricular junction remodeling"], "types": ["T038"], "canonical_name": "atrial ventricular junction remodeling", "definition": "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle. [GOC:mtg_heart]"}
{"concept_id": "C2753691", "aliases": ["cell proliferation involved in atrio-ventricular junction remodeling", "cell proliferation involved in atrioventricular junction remodeling"], "types": ["T043"], "canonical_name": "cell proliferation involved in atrial ventricular junction remodeling", "definition": "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction. [GOC:mtg_heart]"}
{"concept_id": "C2753692", "aliases": ["apoptosis involved in atrio-ventricular junction remodeling", "apoptosis involved in atrioventricular junction remodeling"], "types": ["T043"], "canonical_name": "apoptotic process involved in atrial ventricular junction remodeling", "definition": "Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction. [GOC:mtg_apoptosis, GOC:mtg_heart]"}
{"concept_id": "C2753693", "aliases": [], "types": ["T040"], "canonical_name": "heart wedging", "definition": "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart. [GOC:mtg_heart]"}
{"concept_id": "C2753694", "aliases": [], "types": ["T042"], "canonical_name": "physiological muscle hypertrophy", "definition": "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. [GOC:mtg_heart]"}
{"concept_id": "C2753695", "aliases": [], "types": ["T039"], "canonical_name": "muscle hypertrophy in response to stress", "definition": "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. [GOC:mtg_heart]"}
{"concept_id": "C2753696", "aliases": [], "types": ["T042"], "canonical_name": "physiological cardiac muscle hypertrophy", "definition": "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]"}
{"concept_id": "C2753697", "aliases": ["transforming growth factor beta receptor signalling pathway involved in heart jogging"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in heart jogging", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging. [GOC:mtg_heart, GOC:signaling]"}
{"concept_id": "C2753699", "aliases": ["BMP signalling pathway involved in heart jogging"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in heart jogging", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging. [GOC:mtg_heart]"}
{"concept_id": "C2753700", "aliases": [], "types": ["T042"], "canonical_name": "myocardial epithelial involution involved in heart jogging", "definition": "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging. [GOC:mtg_heart]"}
{"concept_id": "C2753701", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in heart jogging", "definition": "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging. [GOC:mtg_heart]"}
{"concept_id": "C2753702", "aliases": ["Wnt-activated signaling pathway involved in heart development", "Wnt receptor signalling pathway involved in heart development", "Wnt receptor signaling pathway involved in heart development"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in heart development", "definition": "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time. [GOC:mtg_heart]"}
{"concept_id": "C2753703", "aliases": ["regulation of Wnt receptor signaling pathway involved in heart development", "regulation of Wnt receptor signalling pathway involved in heart development", "regulation of Wnt-activated signaling pathway involved in heart development"], "types": ["T044"], "canonical_name": "regulation of Wnt signaling pathway involved in heart development", "definition": "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time. [GOC:mtg_heart]"}
{"concept_id": "C2753704", "aliases": ["negative regulation of Wnt receptor signaling pathway involved in heart development", "negative regulation of Wnt receptor signalling pathway involved in heart development", "negative regulation of Wnt-activated signaling pathway involved in heart development"], "types": ["T043"], "canonical_name": "negative regulation of Wnt signaling pathway involved in heart development", "definition": "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time. [GOC:mtg_heart]"}
{"concept_id": "C2753705", "aliases": ["pancreatic beta cell differentiation", "pancreatic B cell differentiation"], "types": ["T043"], "canonical_name": "type B pancreatic cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. [CL:0000169, GOC:dph, PMID:11076772]"}
{"concept_id": "C2753706", "aliases": ["pancreatic alpha cell differentiation"], "types": ["T043"], "canonical_name": "pancreatic A cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. [GOC:dph, PMID:11076772]"}
{"concept_id": "C2753707", "aliases": ["pancreatic delta cell differentiation"], "types": ["T043"], "canonical_name": "pancreatic D cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. [GOC:dph, PMID:11076772]"}
{"concept_id": "C2753708", "aliases": ["pancreatic polypeptide-producing cell differentiation"], "types": ["T043"], "canonical_name": "pancreatic PP cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. [GOC:dph, PMID:11076772]"}
{"concept_id": "C2753709", "aliases": ["heart cone development"], "types": ["T042"], "canonical_name": "heart rudiment development", "definition": "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. [GOC:mtg_heart]"}
{"concept_id": "C2753710", "aliases": ["heart cone morphogenesis"], "types": ["T042"], "canonical_name": "heart rudiment morphogenesis", "definition": "The process in which the anatomical structures of the heart rudiment are generated and organized. [GOC:mtg_heart]"}
{"concept_id": "C2753711", "aliases": ["heart cone formation"], "types": ["T042"], "canonical_name": "heart rudiment formation", "definition": "The developmental process pertaining to the initial formation of the heart rudiment. [GOC:mtg_heart]"}
{"concept_id": "C2753712", "aliases": ["myocardial progenitor epithelial polarization"], "types": ["T043"], "canonical_name": "establishment of myocardial progenitor cell apical/basal polarity", "definition": "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment. [GOC:mtg_heart]"}
{"concept_id": "C2753713", "aliases": ["cardiac progenitor cell midline fusion"], "types": ["T043"], "canonical_name": "cardioblast cell midline fusion", "definition": "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment. [GOC:mtg_heart]"}
{"concept_id": "C2753714", "aliases": [], "types": ["T043"], "canonical_name": "cell migration to the midline involved in heart development", "definition": "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time. [GOC:mtg_heart]"}
{"concept_id": "C2753715", "aliases": [], "types": ["T043"], "canonical_name": "cardioblast migration to the midline involved in heart rudiment formation", "definition": "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment. [GOC:mtg_heart]"}
{"concept_id": "C2753716", "aliases": [], "types": ["T040"], "canonical_name": "heart rudiment involution", "definition": "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube. [GOC:mtg_heart]"}
{"concept_id": "C2753717", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of blood pressure by epinephrine-norepinephrine", "definition": "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine. [GOC:dph]"}
{"concept_id": "C2753718", "aliases": ["pancreatic alpha cell development"], "types": ["T043"], "canonical_name": "pancreatic A cell development", "definition": "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. [GOC:dph]"}
{"concept_id": "C2753719", "aliases": ["pancreatic beta cell development", "pancreatic B cell development"], "types": ["T043"], "canonical_name": "type B pancreatic cell development", "definition": "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. [CL:0000169, GOC:dph]"}
{"concept_id": "C2753720", "aliases": ["pancreatic delta cell development"], "types": ["T043"], "canonical_name": "pancreatic D cell development", "definition": "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. [GOC:dph]"}
{"concept_id": "C2753721", "aliases": [], "types": ["T043"], "canonical_name": "pancreatic PP cell development", "definition": "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. [GOC:dph]"}
{"concept_id": "C2753722", "aliases": [], "types": ["T043"], "canonical_name": "pancreatic A cell fate commitment", "definition": "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. [GOC:dph]"}
{"concept_id": "C2753723", "aliases": ["pancreatic B cell fate commitment"], "types": ["T043"], "canonical_name": "type B pancreatic cell fate commitment", "definition": "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. [CL:0000169, GOC:dph]"}
{"concept_id": "C2753724", "aliases": [], "types": ["T043"], "canonical_name": "pancreatic D cell fate commitment", "definition": "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin. [GOC:dph]"}
{"concept_id": "C2753725", "aliases": [], "types": ["T043"], "canonical_name": "pancreatic PP cell fate commitment", "definition": "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. [GOC:dph]"}
{"concept_id": "C2753726", "aliases": [], "types": ["T043"], "canonical_name": "regulation of extracellular matrix constituent secretion", "definition": "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753727", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of extracellular matrix constituent secretion", "definition": "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753728", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of extracellular matrix constituent secretion", "definition": "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753729", "aliases": ["amino acid membrane transport"], "types": ["T043"], "canonical_name": "amino acid transmembrane transport", "definition": "The process in which an amino acid is transported across a membrane. [GOC:dph, GOC:tb]"}
{"concept_id": "C2753730", "aliases": [], "types": ["T043"], "canonical_name": "keratinocyte development", "definition": "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C2753731", "aliases": [], "types": ["T043"], "canonical_name": "corneocyte development", "definition": "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis. [GOC:dph]"}
{"concept_id": "C2753732", "aliases": ["epidermal desquamation"], "types": ["T043"], "canonical_name": "corneocyte desquamation", "definition": "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis. [GOC:dph]"}
{"concept_id": "C2753733", "aliases": ["metanephric mesenchyme to epithelial transition"], "types": ["T043"], "canonical_name": "mesenchymal to epithelial transition involved in metanephros morphogenesis", "definition": "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753734", "aliases": [], "types": ["T042"], "canonical_name": "metanephros morphogenesis", "definition": "The process in which the anatomical structures of the metanephros are generated and organized. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753735", "aliases": [], "types": ["T038"], "canonical_name": "regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "definition": "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. [GOC:dph]"}
{"concept_id": "C2753736", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "definition": "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. [GOC:dph, GOC:yaf]"}
{"concept_id": "C2753737", "aliases": ["cilium beating", "microtubule-based flagellum movement"], "types": ["T043"], "canonical_name": "cilium movement", "definition": "The directed, self-propelled movement of a cilium. [GOC:dph, GOC:jl]"}
{"concept_id": "C2753738", "aliases": [], "types": ["T042"], "canonical_name": "proepicardium development", "definition": "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. [GOC:dph, PMID:18722343]"}
{"concept_id": "C2753739", "aliases": [], "types": ["T042"], "canonical_name": "septum transversum development", "definition": "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. [GOC:dph, PMID:18722343]"}
{"concept_id": "C2753740", "aliases": [], "types": ["T042"], "canonical_name": "pericardium morphogenesis", "definition": "The process in which the anatomical structure of the pericardium is generated and organized. [GOC:dph, PMID:18722343]"}
{"concept_id": "C2753741", "aliases": [], "types": ["T043"], "canonical_name": "proepicardium cell migration involved in pericardium morphogenesis", "definition": "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart. [GOC:dph, PMID:18722343]"}
{"concept_id": "C2753742", "aliases": [], "types": ["T043"], "canonical_name": "epicardium-derived cell migration to the myocardium", "definition": "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium. [GOC:dph, PMID:18722343]"}
{"concept_id": "C2753743", "aliases": [], "types": ["T043"], "canonical_name": "epicardial cell to mesenchymal cell transition", "definition": "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium. [GOC:dph, PMID:18722343]"}
{"concept_id": "C2753744", "aliases": [], "types": ["T043"], "canonical_name": "cardiac endothelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. [GOC:dph, PMID:18722343]"}
{"concept_id": "C2753745", "aliases": [], "types": ["T043"], "canonical_name": "epicardium-derived cardiac endothelial cell differentiation", "definition": "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. [GOC:dph, PMID:18722343]"}
{"concept_id": "C2753746", "aliases": [], "types": ["T042"], "canonical_name": "pulmonary myocardium development", "definition": "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein. [GOC:dph, PMID:17638577]"}
{"concept_id": "C2753747", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cilium beating"}
{"concept_id": "C2753748", "aliases": ["regulation of microtubule-based flagellum movement"], "types": ["T043"], "canonical_name": "regulation of cilium movement", "definition": "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. [GOC:dph]"}
{"concept_id": "C2753749", "aliases": ["positive regulation of microtubule-based flagellum movement"], "types": ["T043"], "canonical_name": "positive regulation of cilium movement", "definition": "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. [GOC:dph]"}
{"concept_id": "C2753750", "aliases": ["negative regulation of microtubule-based flagellum movement"], "types": ["T043"], "canonical_name": "negative regulation of cilium movement", "definition": "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. [GOC:dph]"}
{"concept_id": "C2753751", "aliases": [], "types": ["T043"], "canonical_name": "cilium movement involved in otolith formation", "definition": "The directed, self-propelled movement of cilia of inner ear epithelial cells, resulting the aggregation of otolith seed particles. [GOC:dph, GOC:krc, PMID:19043402]"}
{"concept_id": "C2753752", "aliases": ["regulation of microtubule-based flagellum beat frequency"], "types": ["T043"], "canonical_name": "regulation of cilium beat frequency", "definition": "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium. [GOC:dph]"}
{"concept_id": "C2753753", "aliases": ["norepinephrine secreting neuron differentiation"], "types": ["T043"], "canonical_name": "noradrenergic neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline. [GOC:dph]"}
{"concept_id": "C2753754", "aliases": ["norepinephrine secreting neuron development"], "types": ["T043"], "canonical_name": "noradrenergic neuron development", "definition": "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dph]"}
{"concept_id": "C2753755", "aliases": ["norepinephrine secreting neuron fate commitment"], "types": ["T043"], "canonical_name": "noradrenergic neuron fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron. [GOC:dph]"}
{"concept_id": "C2753756", "aliases": [], "types": ["T042"], "canonical_name": "brainstem development", "definition": "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. [GOC:dph]"}
{"concept_id": "C2753757", "aliases": [], "types": ["T043"], "canonical_name": "noradrenergic neuron differentiation involved in brainstem development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem. [GOC:dph]"}
{"concept_id": "C2753758", "aliases": [], "types": ["T043"], "canonical_name": "noradrenergic neuron fate commitment involved in brainstem development", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem. [GOC:dph]"}
{"concept_id": "C2753759", "aliases": [], "types": ["T043"], "canonical_name": "lamellipodium assembly involved in ameboidal cell migration", "definition": "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753760", "aliases": [], "types": ["T043"], "canonical_name": "lamellipodium assembly involved in mesendodermal cell migration", "definition": "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753761", "aliases": [], "types": ["T043"], "canonical_name": "establishment of cell polarity involved in ameboidal cell migration", "definition": "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753762", "aliases": [], "types": ["T043"], "canonical_name": "cell-matrix adhesion involved in ameboidal cell migration", "definition": "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753763", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in ameboidal cell migration", "definition": "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753764", "aliases": [], "types": ["T043"], "canonical_name": "cell-matrix adhesion involved in mesendodermal cell migration", "definition": "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753765", "aliases": [], "types": ["T043"], "canonical_name": "establishment of cell polarity involved in mesendodermal cell migration", "definition": "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753766", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in mesendodermal cell migration", "definition": "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753767", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration", "definition": "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753768", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration", "definition": "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753769", "aliases": [], "types": ["T044"], "canonical_name": "dynamin family protein polymerization involved in membrane fission", "definition": "The process of creating dynamin family protein polymers, compounds composed of a large number of dynamin family protein monomers. Dynamin family protein polymers form around lipid tubes and contribute to membrane fission. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753770", "aliases": [], "types": ["T044"], "canonical_name": "dynamin family protein polymerization involved in mitochondrial fission", "definition": "The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753771", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dynamin family protein polymerization involved in membrane fission", "definition": "Any process that modulates the rate, frequency, or extent of dynamin family protein polymerization involved in mitochondrial fission. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753772", "aliases": ["sphingolipid signaling pathway", "sphingolipid signalling pathway"], "types": ["T044"], "canonical_name": "sphingolipid signaling pathway"}
{"concept_id": "C2753775", "aliases": [], "types": ["T043"], "canonical_name": "establishment of cell polarity involved in gastrulation cell migration", "definition": "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753776", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of cytoskeleton polarity involved in gastrulation", "definition": "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753777", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell morphogenesis involved in gastrulation", "definition": "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753778", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell morphogenesis", "definition": "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753779", "aliases": [], "types": ["T043"], "canonical_name": "apical constriction", "definition": "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753780", "aliases": [], "types": ["T043"], "canonical_name": "apical constriction involved in gastrulation", "definition": "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753781", "aliases": ["cell-cell signalling involved in amphid sensory organ development"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in amphid sensory organ development", "definition": "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753782", "aliases": [], "types": ["T042"], "canonical_name": "amphid sensory organ development", "definition": "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753783", "aliases": [], "types": ["T043"], "canonical_name": "neuron differentiation involved in amphid sensory organ development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753784", "aliases": [], "types": ["T043"], "canonical_name": "neuron development involved in amphid sensory organ development", "definition": "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753785", "aliases": [], "types": ["T043"], "canonical_name": "retrograde extension", "definition": "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753786", "aliases": ["dendrite retrograde extension"], "types": ["T042"], "canonical_name": "dendrite development by retrograde extension", "definition": "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753787", "aliases": [], "types": ["T042"], "canonical_name": "amphid sensory organ dendrite retrograde extension", "definition": "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753788", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in retrograde extension", "definition": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753789", "aliases": [], "types": ["T043"], "canonical_name": "neuron migration involved in retrograde extension", "definition": "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753790", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in dendrite retrograde extension", "definition": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753791", "aliases": [], "types": ["T043"], "canonical_name": "neuron migration involved in dendrite retrograde extension", "definition": "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753792", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in amphid sensory organ dendrite retrograde extension", "definition": "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753793", "aliases": [], "types": ["T043"], "canonical_name": "neuron migration involved in amphid sensory organ dendrite retrograde extension", "definition": "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753794", "aliases": [], "types": ["T043"], "canonical_name": "glial cell differentiation involved in amphid sensory organ development", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753795", "aliases": [], "types": ["T040"], "canonical_name": "cytoneme morphogenesis", "definition": "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753796", "aliases": [], "types": ["T043"], "canonical_name": "regulation of COPII vesicle coating", "definition": "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]"}
{"concept_id": "C2753797", "aliases": ["elongation of an axis"], "types": ["T040"], "canonical_name": "axis elongation", "definition": "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753798", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in axis elongation", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753799", "aliases": [], "types": ["T040"], "canonical_name": "optic vesicle formation", "definition": "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753800", "aliases": [], "types": ["T040"], "canonical_name": "optic vesicle morphogenesis", "definition": "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753801", "aliases": [], "types": ["T040"], "canonical_name": "optic vesicle elongation", "definition": "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753802", "aliases": ["RPE development"], "types": ["T042"], "canonical_name": "retinal pigment epithelium development", "definition": "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753803", "aliases": [], "types": ["T042"], "canonical_name": "neural retina development", "definition": "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753804", "aliases": [], "types": ["T042"], "canonical_name": "optic cup formation involved in camera-type eye development", "definition": "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753805", "aliases": ["optic cup structural organisation"], "types": ["T042"], "canonical_name": "optic cup structural organization", "definition": "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753806", "aliases": [], "types": ["T042"], "canonical_name": "anterior rotation of the optic cup", "definition": "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753807", "aliases": [], "types": ["T043"], "canonical_name": "cell motility involved in camera-type eye morphogenesis", "definition": "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753808", "aliases": [], "types": ["T043"], "canonical_name": "establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis", "definition": "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753809", "aliases": [], "types": ["T043"], "canonical_name": "chondrocyte differentiation involved in endochondral bone morphogenesis", "definition": "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753810", "aliases": [], "types": ["T043"], "canonical_name": "chondrocyte morphogenesis involved in endochondral bone morphogenesis", "definition": "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753811", "aliases": [], "types": ["T043"], "canonical_name": "chondrocyte hypertrophy", "definition": "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753812", "aliases": [], "types": ["T038"], "canonical_name": "endochondral bone growth", "definition": "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753813", "aliases": [], "types": ["T038"], "canonical_name": "growth plate cartilage development", "definition": "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753814", "aliases": [], "types": ["T043"], "canonical_name": "growth plate cartilage chondrocyte differentiation", "definition": "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753815", "aliases": [], "types": ["T043"], "canonical_name": "growth plate cartilage chondrocyte proliferation", "definition": "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753816", "aliases": [], "types": ["T038"], "canonical_name": "regulation of growth plate cartilage chondrocyte proliferation", "definition": "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753817", "aliases": ["growth plate cartilage axis determination"], "types": ["T038"], "canonical_name": "growth plate cartilage axis specification", "definition": "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753818", "aliases": [], "types": ["T038"], "canonical_name": "growth plate cartilage morphogenesis", "definition": "The process in which the anatomical structures of growth plate cartilage are generated and organized. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753819", "aliases": [], "types": ["T043"], "canonical_name": "growth plate cartilage chondrocyte division", "definition": "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753820", "aliases": ["growth plate cartilage chondrocyte polarization"], "types": ["T043"], "canonical_name": "establishment of cell polarity involved in growth plate cartilage chondrocyte division", "definition": "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753821", "aliases": [], "types": ["T043"], "canonical_name": "establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division", "definition": "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753822", "aliases": [], "types": ["T043"], "canonical_name": "cytoskeleton polarization involved in growth plate cartilage chondrocyte division", "definition": "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753823", "aliases": ["regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway"], "types": ["T039"], "canonical_name": "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753824", "aliases": [], "types": ["T043"], "canonical_name": "chondrocyte intercalation involved in growth plate cartilage morphogenesis", "definition": "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753825", "aliases": [], "types": ["T043"], "canonical_name": "growth plate cartilage chondrocyte morphogenesis", "definition": "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753826", "aliases": ["growth plate cartilage chondrocyte hypertrophy"], "types": ["T043"], "canonical_name": "growth plate cartilage chondrocyte growth", "definition": "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753827", "aliases": [], "types": ["T043"], "canonical_name": "growth plate cartilage chondrocyte development", "definition": "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753828", "aliases": [], "types": ["T043"], "canonical_name": "cell growth involved in growth plate cartilage chondrocyte morphogenesis", "definition": "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753829", "aliases": [], "types": ["T043"], "canonical_name": "chondrocyte development involved in endochondral bone morphogenesis", "definition": "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753830", "aliases": ["BMP signalling pathway involved in growth plate cartilage chondrocyte development"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in growth plate cartilage chondrocyte development", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753831", "aliases": ["hedgehog signaling pathway involved in growth plate cartilage chondrocyte development", "hh signaling pathway involved in growth plate cartilage chondrocyte development", "smoothened signalling pathway involved in growth plate cartilage chondrocyte development"], "types": ["T044"], "canonical_name": "smoothened signaling pathway involved in growth plate cartilage chondrocyte development", "definition": "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753832", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell adhesion involved in growth plate cartilage morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753833", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell communication involved in growth plate cartilage morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2753834", "aliases": ["juglone-sensitive cis-trans proline isomerase activity"], "types": ["T044"], "canonical_name": "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity"}
{"concept_id": "C2753836", "aliases": ["ribosomal subunit transport from nucleus to cytoplasm", "ribosomal subunit export from cell nucleus", "ribosomal subunit export out of nucleus", "ribosomal subunit-nucleus export"], "types": ["T043"], "canonical_name": "ribosomal subunit export from nucleus", "definition": "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm. [GOC:ai]"}
{"concept_id": "C2753837", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription involved in G1/S transition of mitotic cell cycle", "definition": "Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C2753838", "aliases": ["pre-snoRNP complex location", "pre-small nucleolar ribonucleoprotein complex", "pre-small nucleolar ribonucleoprotein complex location"], "types": ["T026"], "canonical_name": "pre-snoRNP complex", "definition": "A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes. [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390]"}
{"concept_id": "C2753839", "aliases": ["NDC1 complex location", "NDC1 subcomplex", "NDC1 complex", "NDC1 subcomplex location"], "types": ["T026"], "canonical_name": "nuclear pore transmembrane ring", "definition": "A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex. [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]"}
{"concept_id": "C2753840", "aliases": ["Delta1 complex location", "Delta1 homodimer complex", "Delta1 homodimer complex location"], "types": ["T026"], "canonical_name": "Delta1 complex", "definition": "A protein complex that consists of homodimer of the Notch ligand Delta1. [PMID:12794186]"}
{"concept_id": "C2753841", "aliases": ["gamma-secretase-Delta1 complex location"], "types": ["T026"], "canonical_name": "gamma-secretase-Delta1 complex", "definition": "A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex. [PMID:12794186]"}
{"concept_id": "C2753842", "aliases": ["presenilin complex location", "gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)", "gamma-secretase complex location (APH1B, PSEN1, PSENEN, NCSTN)", "gamma-secretase complex location (APH1A, PSEN2, PSENEN, NCSTN)", "gamma-secretase complex location (APH1A, PSEN1, PSENEN, NCSTN variant)", "gamma-secretase complex location", "gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)", "gamma-secretase complex location (APH1B, PSEN2, PSENEN, NCSTN)", "presenilin complex", "CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)", "gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)", "CD147-gamma-secretase complex location (APH-1a, PS-1, PEN-2, NCT variant)", "gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)"], "types": ["T026"], "canonical_name": "gamma-secretase complex", "definition": "A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein. [GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437]"}
{"concept_id": "C2753843", "aliases": ["SNARE complex location (Stx4, Napa, Vamp3, Nsf, Vamp2)", "Stx4-Napa-Vamp3-Nsf-Vamp2 complex location", "SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)", "endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex location", "Stx4-Napa-Vamp3-Nsf-Vamp2 complex"], "types": ["T026"], "canonical_name": "endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex", "definition": "A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof). [PMID:8973549]"}
{"concept_id": "C2753844", "aliases": ["BRCA1-Rad51 complex location"], "types": ["T026"], "canonical_name": "BRCA1-Rad51 complex", "definition": "A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity. [GOC:mah, PMID:9008167]"}
{"concept_id": "C2753845", "aliases": ["Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex", "synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex location", "SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)", "Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex location", "SNARE complex location (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)"], "types": ["T026"], "canonical_name": "synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex", "definition": "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof). [PMID:8999968]"}
{"concept_id": "C2753846", "aliases": ["ITGA2B-ITGB3-CIB1 complex location", "ITGA2B-ITGB3-CIB1 complex", "alphaIIb-beta3 integrin-CIB complex location"], "types": ["T026"], "canonical_name": "alphaIIb-beta3 integrin-CIB complex", "definition": "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin. [PMID:9030514]"}
{"concept_id": "C2753847", "aliases": ["ITGA2b-ITGB3-CD47-FAK complex location", "ITGA2b-ITGB3-CD47-FAK complex", "alphaIIb-beta3 integrin-CD47-FAK complex location"], "types": ["T026"], "canonical_name": "alphaIIb-beta3 integrin-CD47-FAK complex", "definition": "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK. [PMID:9169439]"}
{"concept_id": "C2753848", "aliases": ["ITGA2b-ITGB3-CD47-SRC complex", "alphaIIb-beta3 integrin-CD47-Src complex location", "ITGA2b-ITGB3-CD47-SRC complex location"], "types": ["T026"], "canonical_name": "alphaIIb-beta3 integrin-CD47-Src complex", "definition": "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src. [PMID:9169439]"}
{"concept_id": "C2753849", "aliases": ["PAS complex location"], "types": ["T026"], "canonical_name": "PAS complex", "definition": "A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p. [PMID:18950639, PMID:19037259, PMID:19158662]"}
{"concept_id": "C2753850", "aliases": ["NtQ-amidase activity"], "types": ["T044"], "canonical_name": "protein-N-terminal glutamine amidohydrolase activity", "definition": "Catalysis of the reaction: protein-N-terminal-L-glutamine + H2O = protein-N-terminal-L-glutamate + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein. [PMID:19560421]"}
{"concept_id": "C2753851", "aliases": [], "types": ["T044"], "canonical_name": "phytoceramidase activity", "definition": "Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine. [GOC:pde, PMID:11356846]"}
{"concept_id": "C2753852", "aliases": ["H3 HAT complex location", "H3 histone acetyltransferase complex location", "H3 HAT complex"], "types": ["T026"], "canonical_name": "H3 histone acetyltransferase complex", "definition": "A multisubunit complex that catalyzes the acetylation of histone H3. [GOC:mah]"}
{"concept_id": "C2753853", "aliases": ["MOZ/MORF histone acetyltransferase complex location"], "types": ["T026"], "canonical_name": "MOZ/MORF histone acetyltransferase complex", "definition": "A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. [PMID:18794358]"}
{"concept_id": "C2753854", "aliases": [], "types": ["T043"], "canonical_name": "D-aspartate transport", "definition": "The directed movement of D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah, GOC:rph]"}
{"concept_id": "C2753855", "aliases": ["D-aspartate import into cell", "D-aspartate uptake", "D-aspartate import"], "types": ["T043"], "canonical_name": "D-aspartate import across plasma membrane", "definition": "The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. [PMID:7914198]"}
{"concept_id": "C2753856", "aliases": ["dihydrosphingosine-1-phosphate phosphohydrolase activity", "sphinganine-1-phosphate phosphatase activity"], "types": ["T044"], "canonical_name": "dihydrosphingosine-1-phosphate phosphatase activity", "definition": "Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate. [GOC:pde, PMID:12815058]"}
{"concept_id": "C2753857", "aliases": ["response to vitamin H", "response to coenzyme R", "response to vitamin B7", "response to Bios IIB"], "types": ["T043"], "canonical_name": "response to biotin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus. [GOC:sl]"}
{"concept_id": "C2753858", "aliases": ["externalization of phosphatidylserine"], "types": ["T043"], "canonical_name": "phosphatidylserine exposure on apoptotic cell surface", "definition": "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity. [GOC:mah, GOC:mtg_apoptosis, GOC:rk, PMID:11536005]"}
{"concept_id": "C2753859", "aliases": [], "types": ["T043"], "canonical_name": "growth of unicellular organism as a thread of attached cells", "definition": "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2753860", "aliases": [], "types": ["T040"], "canonical_name": "regulation of growth of unicellular organism as a thread of attached cells", "definition": "Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium. [GOC:mah]"}
{"concept_id": "C2753861", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of growth of unicellular organism as a thread of attached cells", "definition": "Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium. [GOC:mah]"}
{"concept_id": "C2753862", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of growth of unicellular organism as a thread of attached cells", "definition": "Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium. [GOC:mah]"}
{"concept_id": "C2753863", "aliases": [], "types": ["T043"], "canonical_name": "conidiophore development", "definition": "The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. [PMID:9529886]"}
{"concept_id": "C2753864", "aliases": [], "types": ["T039"], "canonical_name": "conidiophore stalk development", "definition": "The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. [PMID:9529886]"}
{"concept_id": "C2753865", "aliases": ["development of primary sterigmata"], "types": ["T039"], "canonical_name": "metula development", "definition": "The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. [PMID:9529886]"}
{"concept_id": "C2753866", "aliases": ["development of secondary sterigmata"], "types": ["T039"], "canonical_name": "phialide development", "definition": "The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips. [PMID:9529886]"}
{"concept_id": "C2753867", "aliases": [], "types": ["T040"], "canonical_name": "cleistothecium development", "definition": "The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. [ISBN:0471522295, PMID:17446882]"}
{"concept_id": "C2753868", "aliases": ["Huelle cell development", "Hulle cell formation"], "types": ["T039"], "canonical_name": "Hulle cell development", "definition": "The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body. [PMID:19210625]"}
{"concept_id": "C2753869", "aliases": [], "types": ["T043"], "canonical_name": "regulation of conidiophore development", "definition": "Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. [GOC:mah]"}
{"concept_id": "C2753870", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of conidiophore development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. [GOC:mah]"}
{"concept_id": "C2753871", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of conidiophore development", "definition": "Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. [GOC:mah]"}
{"concept_id": "C2753872", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cleistothecium development", "definition": "Any process that modulates the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. [GOC:mah]"}
{"concept_id": "C2753873", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cleistothecium development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. [GOC:mah]"}
{"concept_id": "C2753874", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cleistothecium development", "definition": "Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. [GOC:mah]"}
{"concept_id": "C2753875", "aliases": [], "types": ["T043"], "canonical_name": "regulation of conidiophore stalk development", "definition": "Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. [GOC:mah]"}
{"concept_id": "C2753876", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of conidiophore stalk development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. [GOC:mah]"}
{"concept_id": "C2753877", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of conidiophore stalk development", "definition": "Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. [GOC:mah]"}
{"concept_id": "C2753878", "aliases": [], "types": ["T043"], "canonical_name": "regulation of metula development", "definition": "Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. [GOC:mah]"}
{"concept_id": "C2753879", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of metula development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. [GOC:mah]"}
{"concept_id": "C2753880", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of metula development", "definition": "Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. [GOC:mah]"}
{"concept_id": "C2753881", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phialide development", "definition": "Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. [GOC:mah]"}
{"concept_id": "C2753882", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of phialide development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. [GOC:mah]"}
{"concept_id": "C2753883", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of phialide development", "definition": "Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. [GOC:mah]"}
{"concept_id": "C2753884", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Hulle cell development", "definition": "Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body. [GOC:mah]"}
{"concept_id": "C2753885", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Hulle cell development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body. [GOC:mah]"}
{"concept_id": "C2753886", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Hulle cell development", "definition": "Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body. [GOC:mah]"}
{"concept_id": "C2753887", "aliases": [], "types": ["T043"], "canonical_name": "glycerol-2-phosphate transport"}
{"concept_id": "C2753889", "aliases": ["hydrogen sulphide metabolism", "hydrogen sulfide metabolism", "hydrogen sulphide metabolic process"], "types": ["T044"], "canonical_name": "hydrogen sulfide metabolic process", "definition": "The chemical reactions and pathways involving hydrogen sulfide, H2S. [GOC:mah]"}
{"concept_id": "C2753890", "aliases": ["hydrogen sulfide synthesis", "hydrogen sulphide biosynthesis", "hydrogen sulphide biosynthetic process", "hydrogen sulfide anabolism", "hydrogen sulfide formation", "hydrogen sulfide biosynthesis"], "types": ["T044"], "canonical_name": "hydrogen sulfide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. [GOC:mah]"}
{"concept_id": "C2753891", "aliases": ["peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity", "lysine hydroxylase activity", "peptidyl-lysine 5-dioxygenase activity", "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity", "peptide-lysine 5-dioxygenase activity", "lysine-2-oxoglutarate dioxygenase activity", "protein lysine hydroxylase activity", "lysyl hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2. [PMID:19574390]", "canonical_name": "lysine,2-oxoglutarate 5-dioxygenase activity"}
{"concept_id": "C2753892", "aliases": ["P-TEFb-cap methyltransferase complex localisation", "establishment and maintenance of P-TEFb-cap methyltransferase complex localization"], "types": ["T043"], "canonical_name": "P-TEFb-cap methyltransferase complex localization", "definition": "Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C2753893", "aliases": ["protoporphyrinogen-IX:menaquinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "menaquinone-dependent protoporphyrinogen oxidase activity", "definition": "Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone. [GOC:mah, PMID:19583219]"}
{"concept_id": "C2753894", "aliases": ["gelatinase granule"], "types": ["T026"], "canonical_name": "tertiary granule", "definition": "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]"}
{"concept_id": "C2753895", "aliases": [], "types": ["T026"], "canonical_name": "tertiary granule membrane", "definition": "The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]"}
{"concept_id": "C2753896", "aliases": ["Sin3-type complex location"], "types": ["T026"], "canonical_name": "Sin3-type complex", "definition": "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. [PMID:15565322, PMID:18292778]"}
{"concept_id": "C2753897", "aliases": ["HDA1 complex location"], "types": ["T026"], "canonical_name": "HDA1 complex", "definition": "A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p. [GOC:dgf, GOC:mah, PMID:11287668, PMID:8663039]"}
{"concept_id": "C2753898", "aliases": ["Snf2/HDAC containing repressor complex location", "Snf2/Hdac repressive complex", "Snf2/HDAC containing repressor complex", "Snf2/Hdac repressive complex location", "SHREC complex location"], "types": ["T026"], "canonical_name": "SHREC complex", "definition": "A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures. [GOC:mah, PMID:17289569]"}
{"concept_id": "C2753899", "aliases": [], "types": ["T026"], "canonical_name": "micropyle", "definition": "An external encapsulating structure part of the chorion. A single cone-shaped specialization that forms an opening in the egg chorion that allows sperm entry into the egg prior to fertilization. [GOC:cvs, GOC:mah, PMID:18649270]"}
{"concept_id": "C2753900", "aliases": ["paraferritin complex location"], "types": ["T026"], "canonical_name": "paraferritin complex", "definition": "A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme. [GOC:mah, GOC:rph, PMID:11842004, PMID:8639593]"}
{"concept_id": "C2753902", "aliases": ["heterochromatin organisation", "heterochromatin organization"], "types": ["T045"], "canonical_name": "heterochromatin organization", "definition": "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. [GOC:mah]"}
{"concept_id": "C2753904", "aliases": ["tight junction formation"], "types": ["T043"], "canonical_name": "bicellular tight junction assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. [GOC:mah]"}
{"concept_id": "C2753905", "aliases": [], "types": ["T043"], "canonical_name": "basement membrane assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. [GOC:mah]"}
{"concept_id": "C2753906", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline", "definition": "The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine. [MetaCyc:PWY4FS-2]"}
{"concept_id": "C2753907", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine", "definition": "The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine. [MetaCyc:PWY4FS-3]"}
{"concept_id": "C2753908", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine", "definition": "The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine. [MetaCyc:PWY4FS-4]"}
{"concept_id": "C2753909", "aliases": [], "types": ["T044"], "canonical_name": "chromium ion transmembrane transporter activity", "definition": "Enables the transfer of chromium (Cr) ions from one side of a membrane to the other. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2753910", "aliases": ["caveolar biogenesis", "caveola formation"], "types": ["T043"], "canonical_name": "caveola assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. [GOC:BHF, GOC:mah, GOC:vk, PMID:12633858]"}
{"concept_id": "C2753911", "aliases": ["dehydroascorbate transport"], "types": ["T043"], "canonical_name": "dehydroascorbic acid transport", "definition": "The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C. [GOC:sl]"}
{"concept_id": "C2753914", "aliases": [], "types": ["T044"], "canonical_name": "dynein complex binding", "definition": "Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. [GOC:bf, GOC:BHF, GOC:mah]"}
{"concept_id": "C2753915", "aliases": [], "types": ["T043"], "canonical_name": "inclusion body assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an inclusion body. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753916", "aliases": [], "types": ["T043"], "canonical_name": "aggresome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein. [GOC:BHF, GOC:rl, PMID:14675537]"}
{"concept_id": "C2753917", "aliases": [], "types": ["T043"], "canonical_name": "misfolded protein transport", "definition": "The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. [GOC:BHF, GOC:mah, PMID:14675537]"}
{"concept_id": "C2753918", "aliases": ["polyubiquitylated protein transport"], "types": ["T043"], "canonical_name": "polyubiquitinated protein transport", "definition": "The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. [GOC:BHF, GOC:mah, PMID:14675537]"}
{"concept_id": "C2753919", "aliases": ["polyubiquitylated misfolded protein transport", "misfolded polyubiquitinated protein transport"], "types": ["T043"], "canonical_name": "polyubiquitinated misfolded protein transport", "definition": "The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. [GOC:BHF, GOC:mah, PMID:14675537]"}
{"concept_id": "C2753920", "aliases": [], "types": ["T044"], "canonical_name": "Hsp90 deacetylation", "definition": "The modification of an Hsp90 protein by removal of acetyl groups. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753921", "aliases": ["core mediator complex location", "C mediator complex location", "S mediator complex location", "S mediator complex", "C mediator complex"], "types": ["T026"], "canonical_name": "core mediator complex", "definition": "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. [PMID:11454195, PMID:16168358, PMID:17870225]"}
{"concept_id": "C2753922", "aliases": ["response to growth factor stimulus"], "types": ["T043"], "canonical_name": "response to growth factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753923", "aliases": ["response to epidermal growth factor stimulus", "response to EGF stimulus"], "types": ["T043"], "canonical_name": "response to epidermal growth factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753924", "aliases": ["TACC/TOG complex location"], "types": ["T026"], "canonical_name": "TACC/TOG complex", "definition": "A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase. [GOC:mah, GOC:vw, PMID:19606211]"}
{"concept_id": "C2753925", "aliases": [], "types": ["T044"], "canonical_name": "growth factor receptor binding", "definition": "Binding to a growth factor receptor. [GOC:mah, GOC:vw]"}
{"concept_id": "C2753926", "aliases": ["primary neurite", "cell body fibre"], "types": ["T026"], "canonical_name": "cell body fiber", "definition": "A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches. [GOC:dos, GOC:mah]"}
{"concept_id": "C2753927", "aliases": [], "types": ["T044"], "canonical_name": "myosin VI binding", "definition": "Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:15473855]"}
{"concept_id": "C2753928", "aliases": [], "types": ["T044"], "canonical_name": "myosin VI heavy chain binding", "definition": "Binding to a heavy chain of a myosin VI complex. [GOC:sart]"}
{"concept_id": "C2753929", "aliases": [], "types": ["T044"], "canonical_name": "myosin VI head/neck binding", "definition": "Binding to the head/neck region of a myosin VI heavy chain. [GOC:sart]"}
{"concept_id": "C2753930", "aliases": [], "types": ["T044"], "canonical_name": "myosin VI light chain binding", "definition": "Binding to a light chain of a myosin VI complex. [GOC:sart]"}
{"concept_id": "C2753931", "aliases": ["regulation of bile acid anabolism", "regulation of bile acid formation", "regulation of bile acid synthesis", "regulation of bile acid biosynthesis"], "types": ["T044"], "canonical_name": "regulation of bile acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753932", "aliases": ["downregulation of bile acid biosynthetic process", "negative regulation of bile acid formation", "negative regulation of bile acid biosynthesis", "negative regulation of bile acid anabolism", "down-regulation of bile acid biosynthetic process", "down regulation of bile acid biosynthetic process", "negative regulation of bile acid synthesis"], "types": ["T044"], "canonical_name": "negative regulation of bile acid biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753933", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bile acid biosynthetic process"}
{"concept_id": "C2753934", "aliases": ["positive regulation of bile acid anabolism", "up-regulation of bile acid biosynthetic process", "positive regulation of bile acid synthesis", "positive regulation of bile acid biosynthesis", "up regulation of bile acid biosynthetic process", "positive regulation of bile acid formation", "upregulation of bile acid biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of bile acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2753935", "aliases": [], "types": ["T044"], "canonical_name": "activation of bile acid biosynthetic process"}
{"concept_id": "C2753936", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of bile acid biosynthetic process"}
{"concept_id": "C2753937", "aliases": ["RNA polymerase I core factor complex location"], "types": ["T045"], "canonical_name": "RNA polymerase I core factor complex", "definition": "A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p. [PMID:8702872]"}
{"concept_id": "C2753938", "aliases": ["regulation of protein export from endoplasmic reticulum", "regulation of protein export from ER", "regulation of protein exit from ER"], "types": ["T043"], "canonical_name": "regulation of protein exit from endoplasmic reticulum", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C2753939", "aliases": ["negative regulation of protein exit from ER", "downregulation of protein exit from endoplasmic reticulum", "down-regulation of protein exit from endoplasmic reticulum", "negative regulation of protein export from endoplasmic reticulum", "down regulation of protein exit from endoplasmic reticulum", "negative regulation of protein export from ER"], "types": ["T043"], "canonical_name": "negative regulation of protein exit from endoplasmic reticulum", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C2753940", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein exit from endoplasmic reticulum"}
{"concept_id": "C2753941", "aliases": ["up-regulation of protein exit from endoplasmic reticulum", "up regulation of protein exit from endoplasmic reticulum", "upregulation of protein exit from endoplasmic reticulum", "positive regulation of protein exit from ER", "positive regulation of protein export from endoplasmic reticulum", "positive regulation of protein export from ER"], "types": ["T043"], "canonical_name": "positive regulation of protein exit from endoplasmic reticulum", "definition": "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C2753942", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein exit from endoplasmic reticulum"}
{"concept_id": "C2753943", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of protein exit from endoplasmic reticulum"}
{"concept_id": "C2753944", "aliases": ["F-actin cone"], "types": ["T026"], "canonical_name": "investment cone", "definition": "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization. [GOC:sart, PMID:15829565, PMID:9550716]"}
{"concept_id": "C2753945", "aliases": [], "types": ["T044"], "canonical_name": "sterol-dependent protein binding", "definition": "Binding to a protein or protein complex in the presence of sterols. [GOC:ecd]"}
{"concept_id": "C2753946", "aliases": ["mating projection membrane fusion domain"], "types": ["T026"], "canonical_name": "mating projection tip membrane", "definition": "The portion of the plasma membrane surrounding a mating projection tip. [GOC:mah]"}
{"concept_id": "C2753948", "aliases": [], "types": ["T043"], "canonical_name": "heterochromatin assembly involved in chromatin silencing"}
{"concept_id": "C2753950", "aliases": ["cell wall organisation involved in conjugation with cellular fusion"], "types": ["T043"], "canonical_name": "cell wall organization involved in conjugation with cellular fusion", "definition": "A process of cell wall organization that contributes to conjugation with cellular fusion. [GOC:mah]"}
{"concept_id": "C2753952", "aliases": ["regulation of glycogen metabolism"], "types": ["T044"], "canonical_name": "regulation of glycogen metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. [GOC:mah]"}
{"concept_id": "C2753953", "aliases": ["negative regulation of glycogen metabolism"], "types": ["T044"], "canonical_name": "negative regulation of glycogen metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. [GOC:mah]"}
{"concept_id": "C2753954", "aliases": ["positive regulation of glycogen metabolism"], "types": ["T044"], "canonical_name": "positive regulation of glycogen metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. [GOC:mah]"}
{"concept_id": "C2753955", "aliases": ["SOSS complex location"], "types": ["T026"], "canonical_name": "SOSS complex", "definition": "A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. [PMID:19683501]"}
{"concept_id": "C2753956", "aliases": ["primary microRNA binding", "pri-miRNA binding"], "types": ["T045"], "canonical_name": "primary miRNA binding", "definition": "Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. [GOC:sl, PMID:15531877, PMID:15574589]"}
{"concept_id": "C2753957", "aliases": ["fungal-type cell wall beta-glucan metabolism"], "types": ["T043"], "canonical_name": "fungal-type cell wall beta-glucan metabolic process", "definition": "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells. [GOC:mah, GOC:vw]"}
{"concept_id": "C2753958", "aliases": ["fungal-type cell wall beta-glucan synthesis", "fungal-type cell wall beta-glucan anabolism", "fungal-type cell wall beta-glucan formation", "fungal-type cell wall beta-glucan biosynthesis"], "types": ["T044"], "canonical_name": "fungal-type cell wall beta-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells. [GOC:mah]"}
{"concept_id": "C2753959", "aliases": [], "types": ["T044"], "canonical_name": "regulation of proline transport", "definition": "Any process that modulates the frequency, rate or extent of proline transport. [GOC:mah]"}
{"concept_id": "C2753961", "aliases": ["precursor microRNA binding", "pre-microRNA binding"], "types": ["T045"], "canonical_name": "pre-miRNA binding", "definition": "Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA. [PMID:18951094]"}
{"concept_id": "C2753962", "aliases": ["regulation of calcineurin-NFAT signalling cascade", "regulation of calcineurin-NFAT signaling pathway"], "types": ["T044"], "canonical_name": "regulation of calcineurin-NFAT signaling cascade", "definition": "Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. [GOC:ai]"}
{"concept_id": "C2753964", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcineurin-NFAT signaling cascade"}
{"concept_id": "C2753965", "aliases": ["upregulation of calcineurin-NFAT signaling cascade", "up regulation of calcineurin-NFAT signaling cascade", "up-regulation of calcineurin-NFAT signaling cascade", "positive regulation of calcineurin-NFAT signalling cascade", "positive regulation of calcineurin-NFAT signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of calcineurin-NFAT signaling cascade", "definition": "Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade. [GOC:mah]"}
{"concept_id": "C2753966", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcineurin-NFAT signaling cascade"}
{"concept_id": "C2753967", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of calcineurin-NFAT signaling cascade"}
{"concept_id": "C2753968", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chemical stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. [GOC:mah]"}
{"concept_id": "C2753969", "aliases": ["E-box promoter binding"], "types": ["T045"], "canonical_name": "E-box binding", "definition": "Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. [GOC:BHF, GOC:vk, PMID:11812799]"}
{"concept_id": "C2753970", "aliases": ["platelet alpha-granule organization", "platelet alpha granule organisation", "platelet alpha granule organization and biogenesis"], "types": ["T043"], "canonical_name": "platelet alpha granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets. [GOC:rph, PMID:16123220]"}
{"concept_id": "C2753972", "aliases": [], "types": ["T044"], "canonical_name": "lipoteichoic acid binding", "definition": "Binding to lipoteichoic acid. [GOC:add, PMID:14665680]"}
{"concept_id": "C2753973", "aliases": [], "types": ["T044"], "canonical_name": "lipoteichoic acid receptor activity"}
{"concept_id": "C2753974", "aliases": [], "types": ["T045"], "canonical_name": "transposon integration", "definition": "Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome. [GOC:jp, PMID:10882723]"}
{"concept_id": "C2753975", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transposon integration", "definition": "Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process in which a transposable element is incorporated into another DNA molecule. [GOC:mah]"}
{"concept_id": "C2753976", "aliases": ["down-regulation of transposon integration", "down regulation of transposon integration", "downregulation of transposon integration"], "types": ["T045"], "canonical_name": "negative regulation of transposon integration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule. [GOC:mah]"}
{"concept_id": "C2753977", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transposon integration"}
{"concept_id": "C2753978", "aliases": ["up-regulation of transposon integration", "up regulation of transposon integration", "upregulation of transposon integration"], "types": ["T045"], "canonical_name": "positive regulation of transposon integration", "definition": "Any process that activates or increases the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule. [GOC:mah]"}
{"concept_id": "C2753979", "aliases": [], "types": ["T045"], "canonical_name": "activation of transposon integration"}
{"concept_id": "C2753980", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transposon integration"}
{"concept_id": "C2753981", "aliases": ["RNA polymerase III transcriptional preinitiation complex formation", "RNA polymerase III transcription PIC biosynthesis", "RNA polymerase III transcription PIC formation", "RNA polymerase III transcriptional preinitiation complex assembly"], "types": ["T045"], "canonical_name": "RNA polymerase III preinitiation complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter. [GOC:jp, GOC:txnOH, PMID:11387215, PMID:12381659]"}
{"concept_id": "C2753982", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tRNA wobble uridine modification", "definition": "The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2753983", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tRNA modification", "definition": "The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2753984", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tRNA methylation", "definition": "The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2753985", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tRNA pseudouridine synthesis", "definition": "The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2753986", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tRNA thio-modification", "definition": "The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule. [GOC:mah, GOC:mcc]"}
{"concept_id": "C2753988", "aliases": ["Ser binding"], "types": ["T044"], "canonical_name": "serine binding", "definition": "Binding to 2-amino-3-hydroxypropanoic acid. [GOC:rph]"}
{"concept_id": "C2753989", "aliases": ["aspartate-alanine antiporter activity", "aspartate/alanine antiporter activity"], "types": ["T044"], "canonical_name": "aspartate:alanine antiporter activity", "definition": "Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out). [GOC:dh]"}
{"concept_id": "C2753990", "aliases": ["histidine/histamine antiporter activity", "histidine-histamine antiporter activity"], "types": ["T044"], "canonical_name": "histidine:histamine antiporter activity", "definition": "Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out). [GOC:dh]"}
{"concept_id": "C2753991", "aliases": ["tyrosine-tyramine antiporter activity", "tyrosine/tyramine antiporter activity"], "types": ["T044"], "canonical_name": "tyrosine:tyramine antiporter activity", "definition": "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out). [GOC:dh]"}
{"concept_id": "C2753992", "aliases": ["glutamate: GABA antiporter activity", "glutamate/gamma-aminobutyric acid antiporter activity", "glutamate-gamma-aminobutyric acid antiporter activity"], "types": ["T044"], "canonical_name": "glutamate:gamma-aminobutyric acid antiporter activity", "definition": "Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out). [GOC:dh]"}
{"concept_id": "C2753993", "aliases": [], "types": ["T040"], "canonical_name": "cell wall macromolecule catabolic process involved in cell wall disassembly", "definition": "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall. [GOC:mah]"}
{"concept_id": "C2753994", "aliases": ["global genomic nucleotide-excision repair", "global genome NER", "GGR", "GG-NER", "global genome nucleotide-excision repair"], "types": ["T045"], "definition": "The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. [PMID:10197977, PMID:18794354]", "canonical_name": "global genomic repair"}
{"concept_id": "C2753995", "aliases": ["Ddb1-Ckn1 complex location"], "types": ["T026"], "canonical_name": "Ddb1-Ckn1 complex", "definition": "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases. [PMID:18794354]"}
{"concept_id": "C2753996", "aliases": ["Ddb1-Wdr21 complex location"], "types": ["T026"], "canonical_name": "Ddb1-Wdr21 complex", "definition": "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases. [PMID:18794354]"}
{"concept_id": "C2753997", "aliases": ["UVDE-dependent excision repair", "AER", "UV-damaged DNA endonuclease-dependent excision repair", "UV-damage excision repair"], "types": ["T045"], "definition": "A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). [GOC:mah, PMID:9619100]", "canonical_name": "UVER"}
{"concept_id": "C2753998", "aliases": ["LPA receptor activity"], "types": ["T044"], "canonical_name": "lysophosphatidic acid receptor activity", "definition": "Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, GOC:mah, PMID:15755723]"}
{"concept_id": "C2753999", "aliases": ["IPC synthase complex location", "inositol phosphoceramide synthase complex location", "IPC synthase complex"], "types": ["T026"], "canonical_name": "inositol phosphoceramide synthase complex", "definition": "A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces). [GOC:mah, PMID:19726565]"}
{"concept_id": "C2754000", "aliases": ["IPC synthase regulator activity"], "types": ["T044"], "canonical_name": "inositol phosphoceramide synthase regulator activity", "definition": "Binds to and modulates the activity of inositol phosphoceramide synthase. [GOC:mah]"}
{"concept_id": "C2754001", "aliases": ["production of small RNA involved in gene silencing by RNA"], "types": ["T045"], "canonical_name": "production of small RNA involved in gene silencing by RNA"}
{"concept_id": "C2754003", "aliases": ["regulation of gene silencing by RNA, production of guide RNA", "regulation of gene silencing by RNA, production of small RNA"], "types": ["T045"], "canonical_name": "regulation of production of small RNA involved in gene silencing by RNA", "definition": "Any process that modulates the frequency, rate or extent of the production of small RNA involved in gene silencing by RNA. [GOC:mah]"}
{"concept_id": "C2754004", "aliases": ["regulation of chromatin silencing by small RNA, production of siRNA", "regulation of production of siRNA involved in chromatin silencing by small RNA", "regulation of RNA interference, production of siRNA", "regulation of production of siRNA involved in RNA interference"], "types": ["T045"], "canonical_name": "regulation of siRNA production", "definition": "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of gene silencing by small RNA. [GOC:mah]"}
{"concept_id": "C2754005", "aliases": ["gene silencing by RNA, small RNA loading onto RISC", "RISC assembly"], "types": ["T045"], "canonical_name": "small RNA loading onto RISC"}
{"concept_id": "C2754007", "aliases": [], "types": ["T045"], "canonical_name": "heterochromatin assembly involved in chromatin silencing by small RNA"}
{"concept_id": "C2754008", "aliases": [], "types": ["T043"], "canonical_name": "organelle assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:mah]"}
{"concept_id": "C2754009", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ATP:ADP antiporter activity", "definition": "Any process that modulates the activity of an ATP:ADP antiporter. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754011", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATP:ADP antiporter activity"}
{"concept_id": "C2754012", "aliases": ["ncRNA-mediated regulation of mRNA stability", "regulation of mRNA stability, non-coding RNA-mediated"], "types": ["T045"], "canonical_name": "regulation of mRNA stability, ncRNA-mediated", "definition": "Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. [GOC:jh2]"}
{"concept_id": "C2754013", "aliases": [], "types": ["T045"], "canonical_name": "trans-translation", "definition": "A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes. [GOC:jh2, GOC:mah]"}
{"concept_id": "C2754014", "aliases": ["cotranslational protein tagging", "co-translational protein tagging", "protein modification by trans-translation"], "types": ["T044"], "canonical_name": "trans-translation-dependent protein tagging", "definition": "A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation. [GOC:jh2, GOC:jsg, GOC:mah]"}
{"concept_id": "C2754015", "aliases": [], "types": ["T026"], "canonical_name": "Golgi-associated vesicle lumen", "definition": "The volume enclosed by the membrane of a Golgi-associated vesicle. [GOC:mah]"}
{"concept_id": "C2754016", "aliases": [], "types": ["T044"], "canonical_name": "histone H3 deacetylation", "definition": "The modification of histone H3 by the removal of one or more acetyl groups. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2754017", "aliases": [], "types": ["T044"], "canonical_name": "histone H4 deacetylation", "definition": "The modification of histone H4 by the removal of one or more acetyl groups. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2754018", "aliases": ["coding region determinant-mediated mRNA stabilization"], "types": ["T045"], "canonical_name": "CRD-mediated mRNA stabilization", "definition": "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). [GOC:mah, PMID:19029303]"}
{"concept_id": "C2754019", "aliases": ["3'-untranslated region-mediated mRNA stabilization"], "types": ["T045"], "canonical_name": "3'-UTR-mediated mRNA stabilization", "definition": "An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. [GOC:mah, PMID:19029303]"}
{"concept_id": "C2754020", "aliases": ["protein K48-linked polyubiquitination"], "types": ["T044"], "canonical_name": "protein K48-linked ubiquitination", "definition": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. [GOC:cvs, PMID:15556404]"}
{"concept_id": "C2754021", "aliases": ["coding-region instability determinant -mediated mRNA stability complex location", "CRD-mediated mRNA stability complex location", "coding-region determinant of instability-mediated mRNA stability complex", "coding-region instability determinant -mediated mRNA stability complex", "coding-region determinant of instability-mediated mRNA stability complex location"], "types": ["T026"], "canonical_name": "CRD-mediated mRNA stability complex", "definition": "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9. [GOC:mah, PMID:19029303]"}
{"concept_id": "C2754022", "aliases": ["constriction ring"], "types": ["T026"], "definition": "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles. [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889]", "canonical_name": "contractile ring"}
{"concept_id": "C2754023", "aliases": ["cytokinetic ring"], "types": ["T026"], "canonical_name": "cytokinetic ring"}
{"concept_id": "C2754024", "aliases": ["Dsl1p complex location", "Dsl1p complex", "NZR complex", "NZR complex location", "Dsl1/NZR complex location"], "types": ["T026"], "canonical_name": "Dsl1/NZR complex", "definition": "A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p. [GOC:jh, GOC:mah, PMID:19151722, PMID:21550981]"}
{"concept_id": "C2754025", "aliases": ["CTD domain dephosphorylation of RNA polymerase II", "generation of II(A) form of RNA polymerase II", "generation of hypophosphorylated CTD of RNA polymerase II"], "types": ["T045"], "canonical_name": "dephosphorylation of RNA polymerase II C-terminal domain", "definition": "The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form. [GOC:krc, GOC:mah, PMID:17079683]"}
{"concept_id": "C2754026", "aliases": [], "types": ["T044"], "canonical_name": "eisosome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane. [GOC:al, GOC:jp, GOC:mah, PMID:19564405]"}
{"concept_id": "C2754027", "aliases": ["neutrophil mediated cell killing"], "types": ["T043"], "canonical_name": "neutrophil mediated cytotoxicity", "definition": "The directed killing of a target cell by a neutrophil. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754028", "aliases": ["neutrophil mediated killing of symbiont cell"], "types": ["T043"], "canonical_name": "neutrophil-mediated killing of symbiont cell", "definition": "The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754029", "aliases": ["neutrophil mediated killing of bacterium"], "types": ["T043"], "canonical_name": "neutrophil-mediated killing of bacterium", "definition": "The directed killing of a bacterium by a neutrophil. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754030", "aliases": ["neutrophil mediated killing of gram-negative bacterium"], "types": ["T043"], "canonical_name": "neutrophil-mediated killing of gram-negative bacterium", "definition": "The directed killing of a gram-negative bacterium by a neutrophil. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754031", "aliases": ["neutrophil mediated killing of gram-positive bacterium"], "types": ["T043"], "canonical_name": "neutrophil-mediated killing of gram-positive bacterium", "definition": "The directed killing of a gram-positive bacterium by a neutrophil. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754032", "aliases": ["neutrophil mediated killing of fungus"], "types": ["T043"], "canonical_name": "neutrophil-mediated killing of fungus", "definition": "The directed killing of a fungal cell by a neutrophil. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754033", "aliases": ["regulation of neutrophil mediated cell killing"], "types": ["T043"], "canonical_name": "regulation of neutrophil mediated cytotoxicity", "definition": "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754034", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil mediated killing of symbiont cell", "definition": "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754035", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil mediated killing of bacterium", "definition": "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754036", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil mediated killing of gram-negative bacterium", "definition": "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754037", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil mediated killing of gram-positive bacterium", "definition": "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-positive bacterium, the directed killing of a gram-positive bacterium by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754038", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil mediated killing of fungus", "definition": "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754039", "aliases": ["down regulation of neutrophil mediated cytotoxicity", "negative regulation of neutrophil mediated cell killing", "down-regulation of neutrophil mediated cytotoxicity", "downregulation of neutrophil mediated cytotoxicity"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil mediated cytotoxicity", "definition": "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754040", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil mediated cytotoxicity"}
{"concept_id": "C2754041", "aliases": ["down regulation of neutrophil mediated killing of symbiont cell", "down-regulation of neutrophil mediated killing of symbiont cell", "downregulation of neutrophil mediated killing of symbiont cell"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil mediated killing of symbiont cell", "definition": "Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754042", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil mediated killing of symbiont cell"}
{"concept_id": "C2754043", "aliases": ["down regulation of neutrophil mediated killing of bacterium", "down-regulation of neutrophil mediated killing of bacterium", "downregulation of neutrophil mediated killing of bacterium"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil mediated killing of bacterium", "definition": "Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754044", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil mediated killing of bacterium"}
{"concept_id": "C2754045", "aliases": ["downregulation of neutrophil mediated killing of gram-negative bacterium", "down-regulation of neutrophil mediated killing of gram-negative bacterium", "down regulation of neutrophil mediated killing of gram-negative bacterium"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil mediated killing of gram-negative bacterium", "definition": "Any process that decreases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754046", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil mediated killing of gram-negative bacterium"}
{"concept_id": "C2754047", "aliases": ["downregulation of neutrophil mediated killing of gram-positive bacterium", "down-regulation of neutrophil mediated killing of gram-positive bacterium", "down regulation of neutrophil mediated killing of gram-positive bacterium"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil mediated killing of gram-positive bacterium", "definition": "Any process that decreases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754048", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil mediated killing of gram-positive bacterium"}
{"concept_id": "C2754049", "aliases": ["down-regulation of neutrophil mediated killing of fungus", "down regulation of neutrophil mediated killing of fungus", "downregulation of neutrophil mediated killing of fungus"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil mediated killing of fungus", "definition": "Any process that decreases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754050", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil mediated killing of fungus"}
{"concept_id": "C2754051", "aliases": ["upregulation of neutrophil mediated cytotoxicity", "up regulation of neutrophil mediated cytotoxicity", "up-regulation of neutrophil mediated cytotoxicity", "positive regulation of neutrophil mediated cell killing"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil mediated cytotoxicity", "definition": "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754052", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil mediated cytotoxicity"}
{"concept_id": "C2754053", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neutrophil mediated cytotoxicity"}
{"concept_id": "C2754054", "aliases": ["up regulation of neutrophil mediated killing of symbiont cell", "up-regulation of neutrophil mediated killing of symbiont cell", "upregulation of neutrophil mediated killing of symbiont cell"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil mediated killing of symbiont cell", "definition": "Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754055", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil mediated killing of symbiont cell"}
{"concept_id": "C2754056", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neutrophil mediated killing of symbiont cell"}
{"concept_id": "C2754057", "aliases": ["upregulation of neutrophil mediated killing of bacterium", "up-regulation of neutrophil mediated killing of bacterium", "up regulation of neutrophil mediated killing of bacterium"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil mediated killing of bacterium", "definition": "Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754058", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil mediated killing of bacterium"}
{"concept_id": "C2754059", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neutrophil mediated killing of bacterium"}
{"concept_id": "C2754060", "aliases": ["upregulation of neutrophil mediated killing of gram-negative bacterium", "up-regulation of neutrophil mediated killing of gram-negative bacterium", "up regulation of neutrophil mediated killing of gram-negative bacterium"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil mediated killing of gram-negative bacterium", "definition": "Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754061", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil mediated killing of gram-negative bacterium"}
{"concept_id": "C2754062", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neutrophil mediated killing of gram-negative bacterium"}
{"concept_id": "C2754063", "aliases": ["upregulation of neutrophil mediated killing of gram-positive bacterium", "up-regulation of neutrophil mediated killing of gram-positive bacterium", "up regulation of neutrophil mediated killing of gram-positive bacterium"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil mediated killing of gram-positive bacterium", "definition": "Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754064", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil mediated killing of gram-positive bacterium"}
{"concept_id": "C2754065", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neutrophil mediated killing of gram-positive bacterium"}
{"concept_id": "C2754066", "aliases": ["up regulation of neutrophil mediated killing of fungus", "up-regulation of neutrophil mediated killing of fungus", "upregulation of neutrophil mediated killing of fungus"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil mediated killing of fungus", "definition": "Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil. [GOC:add, GOC:mah]"}
{"concept_id": "C2754067", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil mediated killing of fungus"}
{"concept_id": "C2754068", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of neutrophil mediated killing of fungus"}
{"concept_id": "C2754069", "aliases": ["no-go decay", "no-go mRNA decay", "nuclear-transcribed mRNA degradation, no-go decay", "nuclear-transcribed mRNA breakdown, no-go decay", "nuclear-transcribed mRNA catabolism, no-go decay"], "types": ["T045"], "canonical_name": "nuclear-transcribed mRNA catabolic process, no-go decay", "definition": "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation. [GOC:jp, PMID:16554824]"}
{"concept_id": "C2754070", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme F420 binding", "definition": "Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:dh]"}
{"concept_id": "C2754071", "aliases": ["PQQ binding"], "types": ["T044"], "canonical_name": "pyrroloquinoline quinone binding", "definition": "Binding to pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases. [GOC:dh]"}
{"concept_id": "C2754074", "aliases": ["transitional ER", "ER exit site"], "types": ["T026"], "canonical_name": "endoplasmic reticulum exit site", "definition": "An endoplasmic reticulum part at which COPII-coated vesicles are produced. [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]"}
{"concept_id": "C2754075", "aliases": ["protein localisation in endoplasmic reticulum", "protein localization in ER", "protein localization in endoplasmic reticulum"], "types": ["T043"], "canonical_name": "protein localization to endoplasmic reticulum", "definition": "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C2754076", "aliases": ["protein localisation to endoplasmic reticulum exit site", "protein localization to ER exit site"], "types": ["T043"], "canonical_name": "protein localization to endoplasmic reticulum exit site", "definition": "A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site. [GOC:mah]"}
{"concept_id": "C2754077", "aliases": [], "types": ["T044"], "canonical_name": "POU domain binding", "definition": "Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors. [GOC:mah, GOC:yaf, InterPro:IPR000327]"}
{"concept_id": "C2754078", "aliases": ["Forkhead-associated domain binding"], "types": ["T044"], "canonical_name": "FHA domain binding", "definition": "Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich. [GOC:mah, InterPro:IPR000253]"}
{"concept_id": "C2754079", "aliases": ["Toll-Interleukin receptor domain binding"], "types": ["T044"], "canonical_name": "TIR domain binding", "definition": "Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. [GOC:mah, InterPro:IPR000157]"}
{"concept_id": "C2754080", "aliases": [], "types": ["T042"], "canonical_name": "bone maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. [GOC:dph, GOC:mah]"}
{"concept_id": "C2754081", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated calcium channel complex assembly", "definition": "Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex. [GOC:mh]"}
{"concept_id": "C2754082", "aliases": [], "types": ["T044"], "canonical_name": "protein K11-linked ubiquitination", "definition": "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]"}
{"concept_id": "C2754083", "aliases": ["biphenyl breakdown", "biphenyl degradation", "biphenyl catabolism"], "types": ["T044"], "canonical_name": "biphenyl catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs). [PMID:16310831, PMID:16339959, UniPathway:UPA00155]"}
{"concept_id": "C2754084", "aliases": ["L-asparagine biosynthesis", "L-asparagine anabolism", "L-asparagine formation", "L-asparagine synthesis"], "types": ["T044"], "canonical_name": "L-asparagine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid. [GOC:mah]"}
{"concept_id": "C2754085", "aliases": ["L-asparagine metabolism"], "types": ["T044"], "canonical_name": "L-asparagine metabolic process", "definition": "The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid. [GOC:mah]"}
{"concept_id": "C2754086", "aliases": ["dendritic guidance"], "types": ["T043"], "canonical_name": "dendrite guidance", "definition": "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues. [GOC:sart, PMID:15046878]"}
{"concept_id": "C2754087", "aliases": ["SET binding"], "types": ["T044"], "canonical_name": "SET domain binding", "definition": "Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation. [GOC:sart, Pfam:PF00856, PMID:12575990]"}
{"concept_id": "C2754088", "aliases": ["TFIIK complex location", "TFIIK complex", "transcription factor TFIIK complex location"], "types": ["T026"], "canonical_name": "transcription factor TFIIK complex", "definition": "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7. [GOC:mah, PMID:19818408, PMID:22572993]"}
{"concept_id": "C2754089", "aliases": ["left-right axis specification"], "types": ["T040"], "canonical_name": "left/right axis specification", "definition": "The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). [GOC:dph, GOC:gvg, GOC:mah]"}
{"concept_id": "C2754090", "aliases": [], "types": ["T040"], "canonical_name": "left/right axis determination"}
{"concept_id": "C2754091", "aliases": [], "types": ["T045"], "canonical_name": "error-free translesion synthesis", "definition": "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. [GOC:elh]"}
{"concept_id": "C2754092", "aliases": [], "types": ["T044"], "definition": "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. [GOC:BHF, GOC:mah, GOC:rl]", "canonical_name": "oxidative demethylation"}
{"concept_id": "C2754093", "aliases": [], "types": ["T044"], "canonical_name": "snRNP binding", "definition": "Binding to a small nuclear ribonucleoprotein particle. [GOC:BHF, GOC:mah, GOC:rl]"}
{"concept_id": "C2754094", "aliases": ["translation initiation complex location"], "types": ["T026"], "canonical_name": "translation initiation complex", "definition": "A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. [GOC:hjd, GOC:mah]"}
{"concept_id": "C2754095", "aliases": ["translation preinitiation complex location"], "types": ["T026"], "canonical_name": "translation preinitiation complex", "definition": "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. [GOC:hjd, GOC:mah]"}
{"concept_id": "C2754096", "aliases": [], "types": ["T043"], "canonical_name": "detection of oxidative stress", "definition": "The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal. [GOC:mah]"}
{"concept_id": "C2754097", "aliases": ["NADPH dehydrogenation", "reduced nicotinamide adenine dinucleotide phosphate oxidation", "reduced NADP oxidation", "reduced nicotinamide adenine dinucleotide phosphate dehydrogenation", "NADP (reduced) oxidation", "NADP (reduced) dehydrogenation", "reduced NADP dehydrogenation"], "types": ["T044"], "canonical_name": "NADPH oxidation", "definition": "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754098", "aliases": [], "types": ["T044"], "canonical_name": "type 1 melanocortin receptor binding", "definition": "Binding to a type 1 melanocortin receptor. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754099", "aliases": [], "types": ["T044"], "canonical_name": "type 1 melanocortin receptor ligand"}
{"concept_id": "C2754100", "aliases": ["neuronal cell death", "neuron cell death"], "types": ["T043"], "canonical_name": "neuron death", "definition": "The process of cell death in a neuron. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754101", "aliases": [], "types": ["T042"], "canonical_name": "sensory perception of gravity", "definition": "The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:mah]"}
{"concept_id": "C2754102", "aliases": [], "types": ["T043"], "canonical_name": "detection of mechanical stimulus involved in sensory perception of gravity", "definition": "The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal. [GOC:dos, GOC:mah]"}
{"concept_id": "C2754103", "aliases": ["response to magnetic stimulus"], "types": ["T040"], "canonical_name": "response to magnetism", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus. [GOC:sl]"}
{"concept_id": "C2754104", "aliases": ["U4/U6 snRNP location"], "types": ["T026"], "canonical_name": "U4/U6 snRNP", "definition": "A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897, PMID:14685174]"}
{"concept_id": "C2754105", "aliases": ["U4atac/U6atac snRNP location"], "types": ["T026"], "canonical_name": "U4atac/U6atac snRNP", "definition": "A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4atac and U6atac, a heptameric ring of Sm proteins associated with U4atac, the Lsm2-8 heptameric ring complex associated with U6atac, as well as several proteins that are unique to the U4atac snRNP or U6atac snRNPs, some of which remain associated with the U4atac/U6atac snRNA both while the U4atac snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897, PMID:14685174]"}
{"concept_id": "C2754106", "aliases": ["penta-snRNP complex location", "penta-RNP complex", "penta-RNP complex location"], "types": ["T026"], "canonical_name": "penta-snRNP complex", "definition": "A ribonucleoprotein complex that is formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins. [GOC:krc, GOC:mah, PMID:11804584, PMID:12724403]"}
{"concept_id": "C2754107", "aliases": ["major prespliceosome"], "types": ["T026"], "canonical_name": "U2-type prespliceosome", "definition": "A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]"}
{"concept_id": "C2754108", "aliases": [], "types": ["T026"], "canonical_name": "GT-AG prespliceosome"}
{"concept_id": "C2754109", "aliases": ["mammalian U2-type spliceosomal complex A location"], "types": ["T026"], "canonical_name": "mammalian U2-type spliceosomal complex A"}
{"concept_id": "C2754110", "aliases": ["yeast U2-type spliceosomal complex B location"], "types": ["T026"], "canonical_name": "yeast U2-type spliceosomal complex B"}
{"concept_id": "C2754111", "aliases": ["major precatalytic spliceosome"], "types": ["T026"], "canonical_name": "U2-type precatalytic spliceosome", "definition": "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]"}
{"concept_id": "C2754112", "aliases": [], "types": ["T026"], "canonical_name": "GT-AG precatalytic spliceosome"}
{"concept_id": "C2754113", "aliases": ["mammalian U2-type spliceosomal complex B"], "types": ["T026"], "canonical_name": "mammalian U2-type spliceosomal complex B location"}
{"concept_id": "C2754114", "aliases": ["mammalian U2-type spliceosomal complex B1 location"], "types": ["T026"], "canonical_name": "mammalian U2-type spliceosomal complex B1"}
{"concept_id": "C2754115", "aliases": ["yeast U12-type spliceosomal complex A2-1", "yeast U12-type spliceosomal complex A2-1 location"], "types": ["T026"], "canonical_name": "yeast U12-type spliceosomal complex A2-1"}
{"concept_id": "C2754116", "aliases": ["U2-type activated spliceosome", "major catalytic step 1 spliceosome"], "types": ["T026"], "canonical_name": "U2-type catalytic step 1 spliceosome", "definition": "A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]"}
{"concept_id": "C2754117", "aliases": [], "types": ["T026"], "canonical_name": "GT-AG catalytic step 1 spliceosome"}
{"concept_id": "C2754118", "aliases": ["mammalian U2-type spliceosomal complex B*"], "types": ["T026"], "canonical_name": "mammalian U2-type spliceosomal complex B* location"}
{"concept_id": "C2754119", "aliases": ["mammalian U2-type spliceosomal complex B2 location"], "types": ["T026"], "canonical_name": "mammalian U2-type spliceosomal complex B2"}
{"concept_id": "C2754120", "aliases": ["yeast U2-type spliceosomal complex A1 location"], "types": ["T026"], "canonical_name": "yeast U2-type spliceosomal complex A1"}
{"concept_id": "C2754121", "aliases": ["major catalytic step 2 spliceosome"], "types": ["T026"], "canonical_name": "U2-type catalytic step 2 spliceosome", "definition": "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]"}
{"concept_id": "C2754122", "aliases": [], "types": ["T026"], "canonical_name": "GT-AG catalytic step 2 spliceosome"}
{"concept_id": "C2754123", "aliases": ["mammalian U2-type spliceosomal complex C location"], "types": ["T026"], "canonical_name": "mammalian U2-type spliceosomal complex C"}
{"concept_id": "C2754124", "aliases": ["mammalian U2-type spliceosomal complex C1 location"], "types": ["T026"], "canonical_name": "mammalian U2-type spliceosomal complex C1"}
{"concept_id": "C2754125", "aliases": ["yeast U2-type spliceosomal complex A2-2 location"], "types": ["T026"], "canonical_name": "yeast U2-type spliceosomal complex A2-2"}
{"concept_id": "C2754126", "aliases": ["U2/U5/U6 snRNP complex", "U2/U5/U6 tri-snRNP complex location", "major post-mRNA release spliceosomal complex location", "U2-type post-mRNA release spliceosomal complex location", "major post-mRNA release spliceosomal complex", "U2/U5/U6 snRNP complex location", "U2/U5/U6 tri-snRNP complex"], "types": ["T026"], "canonical_name": "U2-type post-mRNA release spliceosomal complex", "definition": "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]"}
{"concept_id": "C2754127", "aliases": ["GT-AG post-mRNA release spliceosomal complex location"], "types": ["T026"], "canonical_name": "GT-AG post-mRNA release spliceosomal complex"}
{"concept_id": "C2754128", "aliases": ["mammalian U2-type spliceosomal complex I location"], "types": ["T026"], "canonical_name": "mammalian U2-type spliceosomal complex I"}
{"concept_id": "C2754129", "aliases": ["U4atac/U6atac.U5 snRNP complex", "U4atac/U6atac x U5 tri-snRNP complex location", "U4atac/U6atac.U5 snRNP complex location"], "types": ["T026"], "canonical_name": "U4atac/U6atac x U5 tri-snRNP complex", "definition": "A spliceosomal snRNP complex that is formed by the association of the U4atac/U6atac and U5 snRNPs. [GOC:krc, GOC:mah, GOC:pr, ISBN:0879695897, PMID:16201866]"}
{"concept_id": "C2754130", "aliases": ["prespliceosomal complex location", "prespliceosomal complex"], "types": ["T026"], "canonical_name": "prespliceosome", "definition": "A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]"}
{"concept_id": "C2754131", "aliases": ["mammalian spliceosomal complex A location"], "types": ["T026"], "canonical_name": "mammalian spliceosomal complex A"}
{"concept_id": "C2754132", "aliases": ["yeast spliceosomal complex B location"], "types": ["T026"], "canonical_name": "yeast spliceosomal complex B"}
{"concept_id": "C2754133", "aliases": [], "types": ["T026"], "canonical_name": "precatalytic spliceosome", "definition": "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]"}
{"concept_id": "C2754134", "aliases": ["mammalian spliceosomal complex B"], "types": ["T026"], "canonical_name": "mammalian spliceosomal complex B location"}
{"concept_id": "C2754135", "aliases": ["mammalian spliceosomal complex B1 location"], "types": ["T026"], "canonical_name": "mammalian spliceosomal complex B1"}
{"concept_id": "C2754136", "aliases": ["yeast spliceosomal complex A2-1 location"], "types": ["T026"], "canonical_name": "yeast spliceosomal complex A2-1"}
{"concept_id": "C2754137", "aliases": ["activated spliceosome"], "types": ["T026"], "canonical_name": "catalytic step 1 spliceosome", "definition": "A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]"}
{"concept_id": "C2754138", "aliases": ["mammalian spliceosomal complex B*"], "types": ["T026"], "canonical_name": "mammalian spliceosomal complex B* location"}
{"concept_id": "C2754139", "aliases": ["mammalian spliceosomal complex B2 location"], "types": ["T026"], "canonical_name": "mammalian spliceosomal complex B2"}
{"concept_id": "C2754140", "aliases": ["yeast spliceosomal complex A1 location"], "types": ["T026"], "canonical_name": "yeast spliceosomal complex A1"}
{"concept_id": "C2754141", "aliases": [], "types": ["T026"], "canonical_name": "catalytic step 2 spliceosome", "definition": "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]"}
{"concept_id": "C2754142", "aliases": ["mammalian spliceosomal complex C location"], "types": ["T026"], "canonical_name": "mammalian spliceosomal complex C"}
{"concept_id": "C2754143", "aliases": ["mammalian spliceosomal complex C1 location"], "types": ["T026"], "canonical_name": "mammalian spliceosomal complex C1"}
{"concept_id": "C2754144", "aliases": ["yeast spliceosomal complex A2-2 location"], "types": ["T026"], "canonical_name": "yeast spliceosomal complex A2-2"}
{"concept_id": "C2754145", "aliases": ["post-mRNA release spliceosomal complex location"], "types": ["T026"], "canonical_name": "post-mRNA release spliceosomal complex", "definition": "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]"}
{"concept_id": "C2754146", "aliases": ["mammalian spliceosomal complex I location"], "types": ["T026"], "canonical_name": "mammalian spliceosomal complex I"}
{"concept_id": "C2754147", "aliases": ["minor prespliceosome"], "types": ["T026"], "canonical_name": "U12-type prespliceosome", "definition": "A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. [GOC:ab, GOC:krc, GOC:mah, PMID:10197985, PMID:16201866]"}
{"concept_id": "C2754148", "aliases": [], "types": ["T026"], "canonical_name": "AT-AC prespliceosome"}
{"concept_id": "C2754149", "aliases": ["mammalian U12-type spliceosomal complex A location"], "types": ["T026"], "canonical_name": "mammalian U12-type spliceosomal complex A"}
{"concept_id": "C2754150", "aliases": ["yeast U12-type spliceosomal complex B location"], "types": ["T026"], "canonical_name": "yeast U12-type spliceosomal complex B"}
{"concept_id": "C2754151", "aliases": ["minor precatalytic spliceosome"], "types": ["T026"], "canonical_name": "U12-type precatalytic spliceosome", "definition": "A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs. [GOC:ab, GOC:krc, GOC:mah, PMID:16201866]"}
{"concept_id": "C2754152", "aliases": [], "types": ["T026"], "canonical_name": "AT-AC precatalytic spliceosome"}
{"concept_id": "C2754153", "aliases": ["mammalian U12-type spliceosomal complex B"], "types": ["T026"], "canonical_name": "mammalian U12-type spliceosomal complex B location"}
{"concept_id": "C2754154", "aliases": ["mammalian U12-type spliceosomal complex B1 location"], "types": ["T026"], "canonical_name": "mammalian U12-type spliceosomal complex B1"}
{"concept_id": "C2754155", "aliases": ["U12-type activated spliceosome", "minor catalytic step 1 spliceosome"], "types": ["T026"], "canonical_name": "U12-type catalytic step 1 spliceosome", "definition": "A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]"}
{"concept_id": "C2754156", "aliases": [], "types": ["T026"], "canonical_name": "AT-AC catalytic step 1 spliceosome"}
{"concept_id": "C2754157", "aliases": ["mammalian U12-type spliceosomal complex B*"], "types": ["T026"], "canonical_name": "mammalian U12-type spliceosomal complex B* location"}
{"concept_id": "C2754158", "aliases": ["mammalian U12-type spliceosomal complex B2 location"], "types": ["T026"], "canonical_name": "mammalian U12-type spliceosomal complex B2"}
{"concept_id": "C2754159", "aliases": ["yeast U12-type spliceosomal complex A1 location"], "types": ["T026"], "canonical_name": "yeast U12-type spliceosomal complex A1"}
{"concept_id": "C2754160", "aliases": ["minor catalytic step 2 spliceosome"], "types": ["T026"], "canonical_name": "U12-type catalytic step 2 spliceosome", "definition": "A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]"}
{"concept_id": "C2754161", "aliases": [], "types": ["T026"], "canonical_name": "AT-AC catalytic step 2 spliceosome"}
{"concept_id": "C2754162", "aliases": ["mammalian U12-type spliceosomal complex C location"], "types": ["T026"], "canonical_name": "mammalian U12-type spliceosomal complex C"}
{"concept_id": "C2754163", "aliases": ["mammalian U12-type spliceosomal complex C1 location"], "types": ["T026"], "canonical_name": "mammalian U12-type spliceosomal complex C1"}
{"concept_id": "C2754164", "aliases": ["yeast U12-type spliceosomal complex A2-2 location"], "types": ["T026"], "canonical_name": "yeast U12-type spliceosomal complex A2-2"}
{"concept_id": "C2754165", "aliases": ["minor post-mRNA release spliceosomal complex", "U12-type post-mRNA release spliceosomal complex location", "minor post-mRNA release spliceosomal complex location"], "types": ["T026"], "canonical_name": "U12-type post-mRNA release spliceosomal complex", "definition": "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]"}
{"concept_id": "C2754166", "aliases": ["AT-AC post-mRNA release spliceosomal complex location"], "types": ["T026"], "canonical_name": "AT-AC post-mRNA release spliceosomal complex"}
{"concept_id": "C2754167", "aliases": ["mammalian U12-type spliceosomal complex I location"], "types": ["T026"], "canonical_name": "mammalian U12-type spliceosomal complex I"}
{"concept_id": "C2754168", "aliases": ["post-spliceosomal complex location"], "types": ["T026"], "canonical_name": "post-spliceosomal complex", "definition": "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5. [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]"}
{"concept_id": "C2754169", "aliases": ["mammalian spliceosomal complex C2 location"], "types": ["T026"], "canonical_name": "mammalian spliceosomal complex C2"}
{"concept_id": "C2754170", "aliases": ["yeast spliceosomal complex A2-3 location"], "types": ["T026"], "canonical_name": "yeast spliceosomal complex A2-3"}
{"concept_id": "C2754171", "aliases": ["major post-spliceosomal complex", "U2-type post-spliceosomal complex location", "major post-spliceosomal complex location"], "types": ["T026"], "canonical_name": "U2-type post-spliceosomal complex", "definition": "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6. [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]"}
{"concept_id": "C2754172", "aliases": ["GT-AG post-spliceosomal complex location"], "types": ["T026"], "canonical_name": "GT-AG post-spliceosomal complex"}
{"concept_id": "C2754173", "aliases": ["mammalian U2-type spliceosomal complex C2 location"], "types": ["T026"], "canonical_name": "mammalian U2-type spliceosomal complex C2"}
{"concept_id": "C2754174", "aliases": ["yeast U2-type spliceosomal complex A2-3 location"], "types": ["T026"], "canonical_name": "yeast U2-type spliceosomal complex A2-3"}
{"concept_id": "C2754175", "aliases": ["minor post-spliceosomal complex", "U12-type post-spliceosomal complex location", "minor post-spliceosomal complex location"], "types": ["T026"], "canonical_name": "U12-type post-spliceosomal complex", "definition": "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U12 and U6atac. [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]"}
{"concept_id": "C2754176", "aliases": ["AT-AC post-spliceosomal complex location"], "types": ["T026"], "canonical_name": "AT-AC post-spliceosomal complex"}
{"concept_id": "C2754177", "aliases": ["mammalian U12-type spliceosomal complex C2 location"], "types": ["T026"], "canonical_name": "mammalian U12-type spliceosomal complex C2"}
{"concept_id": "C2754178", "aliases": ["yeast U12-type spliceosomal complex A2-3 location"], "types": ["T026"], "canonical_name": "yeast U12-type spliceosomal complex A2-3"}
{"concept_id": "C2754179", "aliases": ["trans spliceosomal complex location"], "types": ["T026"], "canonical_name": "trans spliceosomal complex", "definition": "A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates. [GOC:krc, ISBN:0879697393]"}
{"concept_id": "C2754180", "aliases": ["SL snRNP location"], "types": ["T026"], "canonical_name": "SL snRNP", "definition": "A ribonucleoprotein complex that contains spliced leader (SL) RNA and associated proteins. [GOC:krc, ISBN:0879697393]"}
{"concept_id": "C2754181", "aliases": ["RNA quality control", "aberrant RNA catabolic process"], "types": ["T045"], "canonical_name": "RNA surveillance", "definition": "A process that identifies and degrades defective or aberrant RNAs. [GOC:dgf, GOC:krc, PMID:18644474]"}
{"concept_id": "C2754182", "aliases": ["cytoplasmic aberrant RNA catabolic process", "cytoplasmic RNA quality control"], "types": ["T045"], "canonical_name": "cytoplasmic RNA surveillance", "definition": "The set of processes involved in identifying and degrading defective or aberrant RNAs within the cytoplasm. [GOC:dgf, GOC:krc, PMID:18644474]"}
{"concept_id": "C2754183", "aliases": ["nuclear RNA quality control", "nuclear aberrant RNA catabolic process"], "types": ["T045"], "canonical_name": "nuclear RNA surveillance", "definition": "A process that identifies and degrades defective or aberrant RNAs within the nucleus. [GOC:dgf, GOC:krc, PMID:18644474]"}
{"concept_id": "C2754184", "aliases": ["nuclear aberrant mRNA catabolic process", "nuclear mRNA quality control"], "types": ["T045"], "canonical_name": "nuclear mRNA surveillance", "definition": "A process that identifies and degrades defective or aberrant mRNAs within the nucleus. [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728, PMID:14718167, PMID:18644474]"}
{"concept_id": "C2754185", "aliases": ["nuclear ncRNA quality control", "nuclear aberrant ncRNA catabolic process"], "types": ["T045"], "canonical_name": "nuclear ncRNA surveillance", "definition": "The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the nucleus. [GOC:dgf, GOC:krc, PMID:18644474]"}
{"concept_id": "C2754186", "aliases": ["nuclear mRNA quality control of incorrectly spliced pre-mRNA", "nuclear RNA catabolic process of incorrectly spliced pre-mRNA"], "types": ["T045"], "canonical_name": "nuclear mRNA surveillance of spliceosomal pre-mRNA splicing", "definition": "The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus. [GOC:dgf, GOC:krc, PMID:18644474]"}
{"concept_id": "C2754187", "aliases": ["nuclear mRNA catabolic process of mRNA with aberrant 3'-ends", "nuclear mRNA quality control of mRNAs with aberrant 3'-ends"], "types": ["T045"], "canonical_name": "nuclear mRNA surveillance of mRNA 3'-end processing", "definition": "The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus. [GOC:dgf, GOC:krc, PMID:18644474]"}
{"concept_id": "C2754188", "aliases": ["nuclear mRNA quality control of mRNAs in aberrant mRNPs", "nuclear mRNA catabolic process of mRNAs in aberrant mRNPs"], "types": ["T045"], "canonical_name": "nuclear mRNA surveillance of mRNP export", "definition": "The set of processes involved in identifying and degrading incorrectly formed or aberrant nuclear mRNPs docked at the nuclear pore complex prior to export to the cytoplasm. [GOC:dgf, GOC:krc, PMID:18644474]"}
{"concept_id": "C2754190", "aliases": ["cryptic unstable transcript catabolic process"], "types": ["T045"], "canonical_name": "CUT catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs). [GOC:dgf, GOC:krc]"}
{"concept_id": "C2754191", "aliases": ["nuclear poly(A)-dependent rRNA catabolic process"], "types": ["T045"], "canonical_name": "nuclear polyadenylation-dependent rRNA catabolic process", "definition": "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA. [GOC:dgf, GOC:krc, PMID:15173578, PMID:15572680, PMID:15935758, PMID:17652137, PMID:18591258]"}
{"concept_id": "C2754192", "aliases": [], "types": ["T045"], "canonical_name": "nuclear polyadenylation-dependent snoRNA catabolic process", "definition": "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA. [GOC:dgf, GOC:krc, PMID:15935758]"}
{"concept_id": "C2754193", "aliases": ["nuclear poly(A)-dependent snRNA catabolic process"], "types": ["T045"], "canonical_name": "nuclear polyadenylation-dependent snRNA catabolic process", "definition": "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA. [GOC:dgf, GOC:krc]"}
{"concept_id": "C2754194", "aliases": [], "types": ["T045"], "canonical_name": "nuclear polyadenylation-dependent tRNA catabolic process", "definition": "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA. [GOC:dgf, GOC:krc]"}
{"concept_id": "C2754195", "aliases": [], "types": ["T045"], "canonical_name": "nuclear polyadenylation-dependent CUT catabolic process", "definition": "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT. [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258]"}
{"concept_id": "C2754196", "aliases": ["nuclear poly(A)-dependent antisense transcript catabolic process"], "types": ["T045"], "canonical_name": "nuclear polyadenylation-dependent antisense transcript catabolic process", "definition": "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript. [GOC:dgf, GOC:krc, PMID:18022365]"}
{"concept_id": "C2754197", "aliases": [], "types": ["T045"], "canonical_name": "antisense RNA transcript catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product. [GOC:dgf, GOC:krc]"}
{"concept_id": "C2754198", "aliases": [], "types": ["T045"], "canonical_name": "nuclear polyadenylation-dependent mRNA catabolic process", "definition": "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474]"}
{"concept_id": "C2754199", "aliases": [], "types": ["T045"], "canonical_name": "CUT metabolic process", "definition": "The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcribed from intergenic regions. Many intergenic regions are heavily transcribed, but the transcripts are rarely detected due to rapid degradation by the nuclear exosome. [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436]"}
{"concept_id": "C2754200", "aliases": [], "types": ["T045"], "canonical_name": "histone mRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393]"}
{"concept_id": "C2754201", "aliases": [], "types": ["T045"], "canonical_name": "nuclear histone mRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus. [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393]"}
{"concept_id": "C2754202", "aliases": [], "types": ["T045"], "canonical_name": "nuclear polyadenylation-dependent ncRNA catabolic process", "definition": "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA. [GOC:dgf, GOC:jl, GOC:krc, PMID:17410208]"}
{"concept_id": "C2754203", "aliases": [], "types": ["T045"], "canonical_name": "polyadenylation-dependent mRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. [GOC:dgf, GOC:krc]"}
{"concept_id": "C2754206", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA polyadenylation"}
{"concept_id": "C2754207", "aliases": [], "types": ["T045"], "canonical_name": "polyadenylation-dependent snoRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA. [GOC:dgf, GOC:krc, PMID:18951092]"}
{"concept_id": "C2754208", "aliases": ["alpha9-beta1 integrin-ADAM1 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-ADAM1 complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1. [PMID:11882657]"}
{"concept_id": "C2754209", "aliases": ["ITGA9-ITGB1-ADAM1 complex location"], "types": ["T026"], "canonical_name": "ITGA9-ITGB1-ADAM1 complex"}
{"concept_id": "C2754210", "aliases": ["alpha9-beta1 integrin-ADAM2 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-ADAM2 complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2. [PMID:11882657]"}
{"concept_id": "C2754211", "aliases": ["ITGA9-ITGB1-ADAM2 complex location"], "types": ["T026"], "canonical_name": "ITGA9-ITGB1-ADAM2 complex"}
{"concept_id": "C2754212", "aliases": ["alpha9-beta1 integrin-ADAM3 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-ADAM3 complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3. [PMID:11882657]"}
{"concept_id": "C2754213", "aliases": ["ITGA9-ITGB1-ADAM3 complex location"], "types": ["T026"], "canonical_name": "ITGA9-ITGB1-ADAM3 complex"}
{"concept_id": "C2754214", "aliases": ["alpha9-beta1 integrin-ADAM9 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-ADAM9 complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9. [PMID:11882657]"}
{"concept_id": "C2754215", "aliases": ["ITGA9-ITGB1-ADAM9 complex location"], "types": ["T026"], "canonical_name": "ITGA9-ITGB1-ADAM9 complex"}
{"concept_id": "C2754216", "aliases": ["alpha9-beta1 integrin-ADAM15 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-ADAM15 complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15. [PMID:11882657]"}
{"concept_id": "C2754217", "aliases": ["ITGA9-ITGB1-ADAM15 complex location"], "types": ["T026"], "canonical_name": "ITGA9-ITGB1-ADAM15 complex"}
{"concept_id": "C2754218", "aliases": ["alphav-beta3 integrin-ADAM15 complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-ADAM15 complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15. [PMID:10944520, PMID:11882657]"}
{"concept_id": "C2754219", "aliases": ["ITGAV-ITGB3-ADAM15 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3-ADAM15 complex"}
{"concept_id": "C2754220", "aliases": ["alpha3-beta1 integrin-CD151 complex location"], "types": ["T026"], "canonical_name": "alpha3-beta1 integrin-CD151 complex", "definition": "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151. [PMID:10811835, PMID:11884516]"}
{"concept_id": "C2754221", "aliases": ["ITGA3-ITGB1-CD151 complex location"], "types": ["T026"], "canonical_name": "ITGA3-ITGB1-CD151 complex"}
{"concept_id": "C2754222", "aliases": ["alpha6-beta1 integrin-CD151 complex location"], "types": ["T026"], "canonical_name": "alpha6-beta1 integrin-CD151 complex", "definition": "A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151. [PMID:11884516]"}
{"concept_id": "C2754223", "aliases": ["ITGA6-ITGB1-CD151 complex location"], "types": ["T026"], "canonical_name": "ITGA6-ITGB1-CD151 complex"}
{"concept_id": "C2754224", "aliases": ["alpha7-beta1 integrin-CD151 complex location"], "types": ["T026"], "canonical_name": "alpha7-beta1 integrin-CD151 complex", "definition": "A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151. [PMID:11884516]"}
{"concept_id": "C2754225", "aliases": ["ITGA7-ITGB1-CD151 complex location"], "types": ["T026"], "canonical_name": "ITGA7-ITGB1-CD151 complex"}
{"concept_id": "C2754226", "aliases": ["alpha6-beta4 integrin-CD151 complex location"], "types": ["T026"], "canonical_name": "alpha6-beta4 integrin-CD151 complex", "definition": "A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151. [PMID:10811835]"}
{"concept_id": "C2754227", "aliases": ["ITGA6-ITGB4-CD151 complex location"], "types": ["T026"], "canonical_name": "ITGA6-ITGB4-CD151 complex"}
{"concept_id": "C2754228", "aliases": ["alphav-beta3 integrin-vitronectin complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-vitronectin complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin. [PMID:10835423]"}
{"concept_id": "C2754229", "aliases": ["ITGAV-ITGB3-VTN complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3-VTN complex"}
{"concept_id": "C2754230", "aliases": ["perception of wind", "sensory perception of air flow"], "types": ["T042"], "canonical_name": "sensory perception of wind", "definition": "The series of events required for an organism to receive sensory mechanical stimulus resulting from air flow, convert it to a molecular signal, and recognize and characterize the signal. [GOC:mah, PMID:19279637]"}
{"concept_id": "C2754231", "aliases": ["alphaE-beta7 integrin-E-cadherin complex location"], "types": ["T026"], "canonical_name": "alphaE-beta7 integrin-E-cadherin complex", "definition": "A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin. [PMID:10837471]"}
{"concept_id": "C2754232", "aliases": ["ITGAE-ITGB7-CDH1 complex location"], "types": ["T026"], "canonical_name": "ITGAE-ITGB7-CDH1 complex"}
{"concept_id": "C2754233", "aliases": ["alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1. [PMID:10209034]"}
{"concept_id": "C2754234", "aliases": ["ITGA9-ITGB1-VCAM1 complex location"], "types": ["T026"], "canonical_name": "ITGA9-ITGB1-VCAM1 complex"}
{"concept_id": "C2754235", "aliases": ["perception of wind, detection of mechanical stimulus", "sensory transduction of wind", "detection of mechanical stimulus involved in sensory perception of air flow", "perception of wind, sensory transduction of mechanical stimulus", "sensory transduction of mechanical stimulus during perception of wind", "perception of wind, sensory detection of mechanical stimulus", "detection of wind", "sensory detection of mechanical stimulus during perception of wind"], "types": ["T040"], "canonical_name": "detection of mechanical stimulus involved in sensory perception of wind", "definition": "The series of events involved in the perception of wind in which a mechanical stimulus is received and converted into a molecular signal. [GOC:dos, GOC:mah, PMID:19279637]"}
{"concept_id": "C2754236", "aliases": ["alphav-beta3 integrin-ADAM23 complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-ADAM23 complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23. [PMID:10749942]"}
{"concept_id": "C2754237", "aliases": ["ITGAV-ITGB3-ADAM23 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3-ADAM23 complex"}
{"concept_id": "C2754238", "aliases": ["alpha9-beta1 integrin-ADAM12 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-ADAM12 complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12. [PMID:10944520]"}
{"concept_id": "C2754239", "aliases": ["ITGA9-ITGB1-ADAM12 complex location"], "types": ["T026"], "canonical_name": "ITGA9-ITGB1-ADAM12 complex"}
{"concept_id": "C2754240", "aliases": ["alpha4-beta1 integrin-thrombospondin-1 complex location"], "types": ["T026"], "canonical_name": "alpha4-beta1 integrin-thrombospondin-1 complex", "definition": "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1. [PMID:11980922]"}
{"concept_id": "C2754241", "aliases": ["ITGA4-ITGB1-THBS1 complex location"], "types": ["T026"], "canonical_name": "ITGA4-ITGB1-THBS1 complex"}
{"concept_id": "C2754242", "aliases": ["alpha4-beta1 integrin-thrombospondin-2 complex location"], "types": ["T026"], "canonical_name": "alpha4-beta1 integrin-thrombospondin-2 complex", "definition": "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2. [PMID:11980922]"}
{"concept_id": "C2754243", "aliases": ["ITGA4-ITGB1-THBS2 complex location"], "types": ["T026"], "canonical_name": "ITGA4-ITGB1-THBS2 complex"}
{"concept_id": "C2754244", "aliases": ["regulation of phospholipid synthesis", "regulation of phospholipid biosynthesis", "regulation of phospholipid anabolism", "regulation of phospholipid formation"], "types": ["T044"], "canonical_name": "regulation of phospholipid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. [GOC:mah]"}
{"concept_id": "C2754245", "aliases": ["down regulation of phospholipid biosynthetic process", "negative regulation of phospholipid synthesis", "negative regulation of phospholipid anabolism", "downregulation of phospholipid biosynthetic process", "negative regulation of phospholipid formation", "negative regulation of phospholipid biosynthesis", "down-regulation of phospholipid biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of phospholipid biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. [GOC:mah]"}
{"concept_id": "C2754246", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phospholipid biosynthetic process"}
{"concept_id": "C2754247", "aliases": ["positive regulation of phospholipid synthesis", "up-regulation of phospholipid biosynthetic process", "upregulation of phospholipid biosynthetic process", "up regulation of phospholipid biosynthetic process", "positive regulation of phospholipid biosynthesis", "positive regulation of phospholipid anabolism", "positive regulation of phospholipid formation"], "types": ["T044"], "canonical_name": "positive regulation of phospholipid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. [GOC:mah]"}
{"concept_id": "C2754248", "aliases": [], "types": ["T044"], "canonical_name": "activation of phospholipid biosynthetic process"}
{"concept_id": "C2754249", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of phospholipid biosynthetic process"}
{"concept_id": "C2754250", "aliases": [], "types": ["T044"], "canonical_name": "eukaryotic initiation factor eIF2 binding", "definition": "Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation. [GOC:hjd]"}
{"concept_id": "C2754251", "aliases": ["CUGBP1-eIF2 complex location"], "types": ["T026"], "canonical_name": "CUGBP1-eIF2 complex", "definition": "A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation. [PMID:16931514]"}
{"concept_id": "C2754252", "aliases": [], "types": ["T045"], "canonical_name": "RNA 3' uridylation", "definition": "The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule. [GOC:vw, PMID:19430462]"}
{"concept_id": "C2754253", "aliases": ["adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity", "adenosine 3',5'-diphosphate transporter activity"], "types": ["T044"], "canonical_name": "adenosine 3',5'-bisphosphate transmembrane transporter activity", "definition": "Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2754254", "aliases": ["fibronectin-tissue transglutaminase complex location"], "types": ["T026"], "canonical_name": "fibronectin-tissue transglutaminase complex", "definition": "A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion. [PMID:10684262]"}
{"concept_id": "C2754255", "aliases": ["FN-TGM2 complex location"], "types": ["T026"], "canonical_name": "FN-TGM2 complex"}
{"concept_id": "C2754256", "aliases": ["alpha2-beta1 integrin-chondroadherin complex location"], "types": ["T026"], "canonical_name": "alpha2-beta1 integrin-chondroadherin complex", "definition": "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin. [PMID:9281592]"}
{"concept_id": "C2754257", "aliases": ["ITGA2-ITGB1-CHAD complex location"], "types": ["T026"], "canonical_name": "ITGA2-ITGB1-CHAD complex"}
{"concept_id": "C2754258", "aliases": ["alpha3-beta1 integrin-basigin complex location"], "types": ["T026"], "canonical_name": "alpha3-beta1 integrin-basigin complex", "definition": "A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin. [PMID:9360995]"}
{"concept_id": "C2754259", "aliases": ["ITGA3-ITGB1-BSG complex location"], "types": ["T026"], "canonical_name": "ITGA3-ITGB1-BSG complex"}
{"concept_id": "C2754260", "aliases": ["alpha3-beta1 integrin-CD63 complex location"], "types": ["T026"], "canonical_name": "alpha3-beta1 integrin-CD63 complex", "definition": "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63. [PMID:7629079]"}
{"concept_id": "C2754261", "aliases": ["ITGA3-ITGB1-CD63 complex location"], "types": ["T026"], "canonical_name": "ITGA3-ITGB1-CD63 complex"}
{"concept_id": "C2754262", "aliases": ["alpha9-beta1 integrin-tenascin complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-tenascin complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin. [PMID:9565552]"}
{"concept_id": "C2754263", "aliases": ["ITGA9-ITGB1-TNC complex location"], "types": ["T026"], "canonical_name": "ITGA9-ITGB1-TNC complex"}
{"concept_id": "C2754264", "aliases": ["alphaV-beta3 integrin-CD47-FCER2 complex location"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-CD47-FCER2 complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2). [PMID:10037797]"}
{"concept_id": "C2754265", "aliases": ["ITGAV-ITGB3-CD447-FCER2 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3-CD447-FCER2 complex"}
{"concept_id": "C2754266", "aliases": ["alpha2-beta1 integrin-CD47 complex location"], "types": ["T026"], "canonical_name": "alpha2-beta1 integrin-CD47 complex", "definition": "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47. [PMID:10397731]"}
{"concept_id": "C2754267", "aliases": ["ITGA2-ITGB1-CD47 complex location"], "types": ["T026"], "canonical_name": "ITGA2-ITGB1-CD47 complex"}
{"concept_id": "C2754268", "aliases": ["alphaIIb-beta3 integrin-CD9 complex location"], "types": ["T026"], "canonical_name": "alphaIIb-beta3 integrin-CD9 complex", "definition": "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9. [PMID:10429193]"}
{"concept_id": "C2754269", "aliases": ["ITGA2b-ITGB3-CD9 complex location"], "types": ["T026"], "canonical_name": "ITGA2b-ITGB3-CD9 complex"}
{"concept_id": "C2754270", "aliases": ["alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex location"], "types": ["T026"], "canonical_name": "alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex", "definition": "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib. [PMID:10429193]"}
{"concept_id": "C2754271", "aliases": ["ITGA2b-ITGB3-CD9-GP1b-CD47 complex location"], "types": ["T026"], "canonical_name": "ITGA2b-ITGB3-CD9-GP1b-CD47 complex"}
{"concept_id": "C2754272", "aliases": ["alpha11-beta1 integrin-collagen type I complex location"], "types": ["T026"], "canonical_name": "alpha11-beta1 integrin-collagen type I complex", "definition": "A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen. [PMID:10464311]"}
{"concept_id": "C2754273", "aliases": ["ITGA11-ITGB1-COL1A1 complex location"], "types": ["T026"], "canonical_name": "ITGA11-ITGB1-COL1A1 complex"}
{"concept_id": "C2754274", "aliases": ["alpha5-beta1 integrin-tissue transglutaminase complex location"], "types": ["T026"], "canonical_name": "alpha5-beta1 integrin-tissue transglutaminase complex", "definition": "A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase. [PMID:10684262]"}
{"concept_id": "C2754275", "aliases": ["ITGA5-ITGB1-TGM2 complex location"], "types": ["T026"], "canonical_name": "ITGA5-ITGB1-TGM2 complex"}
{"concept_id": "C2754276", "aliases": ["alphaV-beta3 integrin-tissue transglutaminase complex location"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-tissue transglutaminase complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase. [PMID:10684262]"}
{"concept_id": "C2754277", "aliases": ["ITGAV-ITGB3-TGM2 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3-TGM2 complex"}
{"concept_id": "C2754278", "aliases": ["alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex location"], "types": ["T026"], "canonical_name": "alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex", "definition": "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase. [PMID:10684262]"}
{"concept_id": "C2754279", "aliases": ["ITGA2b-ITGB3-FN1-TGM2 complex location"], "types": ["T026"], "canonical_name": "ITGA2b-ITGB3-FN1-TGM2 complex"}
{"concept_id": "C2754280", "aliases": ["alpha1-beta1 integrin-tissue transglutaminase complex location"], "types": ["T026"], "canonical_name": "alpha1-beta1 integrin-tissue transglutaminase complex", "definition": "A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase. [PMID:10684262]"}
{"concept_id": "C2754281", "aliases": ["ITGA1-ITGB1-TGM2 complex location"], "types": ["T026"], "canonical_name": "ITGA1-ITGB1-TGM2 complex"}
{"concept_id": "C2754282", "aliases": ["alpha3-beta1 integrin-tissue transglutaminase complex location"], "types": ["T026"], "canonical_name": "alpha3-beta1 integrin-tissue transglutaminase complex", "definition": "A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase. [PMID:10684262]"}
{"concept_id": "C2754283", "aliases": ["ITGA3-ITGB1-TGM2 complex location"], "types": ["T026"], "canonical_name": "ITGA3-ITGB1-TGM2 complex"}
{"concept_id": "C2754284", "aliases": ["alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex location"], "types": ["T026"], "canonical_name": "alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex", "definition": "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase. [PMID:10684262]"}
{"concept_id": "C2754285", "aliases": ["ITGA5-ITGB1-FN1-TGM2 complex location"], "types": ["T026"], "canonical_name": "ITGA5-ITGB1-FN1-TGM2 complex"}
{"concept_id": "C2754286", "aliases": ["alpha6-beta4 integrin-CD9 complex location"], "types": ["T026"], "canonical_name": "alpha6-beta4 integrin-CD9 complex", "definition": "A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9. [PMID:10711425]"}
{"concept_id": "C2754287", "aliases": ["ITGA6-ITGB4-CD9 complex location"], "types": ["T026"], "canonical_name": "ITGA6-ITGB4-CD9 complex"}
{"concept_id": "C2754288", "aliases": ["alpha3-beta1 integrin-thrombospondin complex location"], "types": ["T026"], "canonical_name": "alpha3-beta1 integrin-thrombospondin complex", "definition": "A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin. [PMID:11358957]"}
{"concept_id": "C2754289", "aliases": ["ITGA3-ITGB1-THBS1 complex location"], "types": ["T026"], "canonical_name": "ITGA3-ITGB1-THBS1 complex"}
{"concept_id": "C2754290", "aliases": ["alphaV-beta3 integrin-gelsolin complex location"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-gelsolin complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin. [PMID:11577104]"}
{"concept_id": "C2754291", "aliases": ["ITGAV-ITGB3-Gsn complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3-Gsn complex"}
{"concept_id": "C2754292", "aliases": ["alphaV-beta3 integrin-paxillin-Pyk2 complex location"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-paxillin-Pyk2 complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2. [PMID:11683411]"}
{"concept_id": "C2754293", "aliases": ["ITGAV-ITGB3-PXN-PTK2b complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB3-PXN-PTK2b complex"}
{"concept_id": "C2754294", "aliases": ["alpha6-beta4 integrin-Fyn complex location"], "types": ["T026"], "canonical_name": "alpha6-beta4 integrin-Fyn complex", "definition": "A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn. [PMID:11684709]"}
{"concept_id": "C2754295", "aliases": ["ITGA6-ITGB4-FYN complex location"], "types": ["T026"], "canonical_name": "ITGA6-ITGB4-FYN complex"}
{"concept_id": "C2754296", "aliases": ["alphaV-beta6 integrin-TGFbeta-3 complex location"], "types": ["T026"], "canonical_name": "alphaV-beta6 integrin-TGFbeta-3 complex", "definition": "A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3). [PMID:11821050]"}
{"concept_id": "C2754297", "aliases": ["ITGAV-ITGB6-TFGB3 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB6-TFGB3 complex"}
{"concept_id": "C2754298", "aliases": ["alphaV-beta8 integrin-MMP14-TGFbeta-1 complex location"], "types": ["T026"], "canonical_name": "alphaV-beta8 integrin-MMP14-TGFbeta-1 complex", "definition": "A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1). [PMID:11970960]"}
{"concept_id": "C2754299", "aliases": ["ITGAV-ITGB8-MMP14-TGFB1 complex location"], "types": ["T026"], "canonical_name": "ITGAV-ITGB8-MMP14-TGFB1 complex"}
{"concept_id": "C2754300", "aliases": ["alpha4-beta1 integrin-JAM2 complex location"], "types": ["T026"], "canonical_name": "alpha4-beta1 integrin-JAM2 complex", "definition": "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2. [PMID:12070135]"}
{"concept_id": "C2754301", "aliases": ["ITGA4-ITGB1-JAM2 complex location"], "types": ["T026"], "canonical_name": "ITGA4-ITGB1-JAM2 complex"}
{"concept_id": "C2754302", "aliases": ["alpha4-beta1 integrin-paxillin complex location"], "types": ["T026"], "canonical_name": "alpha4-beta1 integrin-paxillin complex", "definition": "A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin. [PMID:12221126]"}
{"concept_id": "C2754303", "aliases": ["ITGA4-ITGB1-PXN complex location"], "types": ["T026"], "canonical_name": "ITGA4-ITGB1-PXN complex"}
{"concept_id": "C2754304", "aliases": ["DNA conformation modification"], "types": ["T043"], "canonical_name": "DNA conformation change", "definition": "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. [GOC:mah]"}
{"concept_id": "C2754305", "aliases": ["response to IL-9"], "types": ["T043"], "canonical_name": "response to interleukin-9", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754306", "aliases": ["response to IL-11"], "types": ["T043"], "canonical_name": "response to interleukin-11", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754307", "aliases": ["adenosine 3',5'-diphosphate transport", "adenosine 3'-phosphate-5'-phosphate transmembrane transport", "adenosine 3',5'-bisphosphate membrane transport"], "types": ["T043"], "canonical_name": "adenosine 3',5'-bisphosphate transmembrane transport", "definition": "The process in which adenosine 3',5'-bisphosphate is transported across a membrane. [GOC:mah]"}
{"concept_id": "C2754308", "aliases": ["response to parathyroid hormone stimulus"], "types": ["T043"], "canonical_name": "response to parathyroid hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754309", "aliases": [], "types": ["T044"], "canonical_name": "protein K48-linked deubiquitination", "definition": "A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. [GOC:mah]"}
{"concept_id": "C2754310", "aliases": [], "types": ["T042"], "canonical_name": "superior temporal gyrus development", "definition": "The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus. [FMA:61905, GOC:BHF, GOC:mah, PMID:11484000]"}
{"concept_id": "C2754312", "aliases": ["PDEA1", "c-di-GMP-specific phosphodiesterase activity", "c-di-GMP phosphodiesterase activity", "VieA", "cyclic bis(3->5')diguanylate phosphodiesterase activity"], "types": ["T044"], "canonical_name": "cyclic-guanylate-specific phosphodiesterase activity", "definition": "Catalysis of the reaction: cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine + H(+). [EC:3.1.4.52, RHEA:24902]"}
{"concept_id": "C2754313", "aliases": [], "types": ["T044"], "canonical_name": "phosphodiesterase A1 activity"}
{"concept_id": "C2754314", "aliases": ["ITGA4-ITGB4-EMILIN1 complex location", "alpha4-beta4 integrin-EMILIN-1 complex location", "ITGA4-ITGB4-EMILIN1 complex"], "types": ["T026"], "canonical_name": "alpha4-beta4 integrin-EMILIN-1 complex", "definition": "A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN). [PMID:12456677]"}
{"concept_id": "C2754315", "aliases": ["ITGAIIb-ITGB3-ICAM4 complex location", "alphaIIb-beta3 integrin-ICAM-4 complex location", "ITGAIIb-ITGB3-ICAM4 complex"], "types": ["T026"], "canonical_name": "alphaIIb-beta3 integrin-ICAM-4 complex", "definition": "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4. [PMID:12477717]"}
{"concept_id": "C2754316", "aliases": ["ITGAV-ITGB3-COL4A3 complex", "ITGAV-ITGB3-COL4A3 complex location", "alphaV-beta3 integrin-tumstatin complex location"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-tumstatin complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen. [PMID:12682293]"}
{"concept_id": "C2754317", "aliases": ["ITGA5-ITGB1-CAL4A3 complex", "ITGA5-ITGB1-CAL4A3 complex location", "alpha5-beta1 integrin-endostatin complex location"], "types": ["T026"], "canonical_name": "alpha5-beta1 integrin-endostatin complex", "definition": "A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen. [PMID:12682293]"}
{"concept_id": "C2754318", "aliases": ["ITGA6-ITGB1-CYR61 complex", "ITGA6-ITGB1-CYR61 complex location", "alpha6-beta1 integrin-CYR61 complex location"], "types": ["T026"], "canonical_name": "alpha6-beta1 integrin-CYR61 complex", "definition": "A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis. [PMID:12826661]"}
{"concept_id": "C2754319", "aliases": ["ITGA5-ITGB1-FN-1-NOV complex", "ITGA5-ITGB1-FN-1-NOV complex location", "alpha5-beta1 integrin-fibronectin-NOV complex location"], "types": ["T026"], "canonical_name": "alpha5-beta1 integrin-fibronectin-NOV complex", "definition": "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV. [PMID:12902636]"}
{"concept_id": "C2754320", "aliases": ["alphaV-beta3 integrin-NOV complex location", "ITGAV-ITGB3-FN-1-NOV complex", "ITGAV-ITGB3-FN-1-NOV complex location"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-NOV complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV. [PMID:12902636]"}
{"concept_id": "C2754321", "aliases": ["alpha7-beta1 integrin-nicotinamide riboside kinase complex location", "ITGA7-ITGB1-ITGB1BP3 complex location", "ITGA7-ITGB1-ITGB1BP3 complex"], "types": ["T026"], "canonical_name": "alpha7-beta1 integrin-nicotinamide riboside kinase complex", "definition": "A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP). [PMID:12941630]"}
{"concept_id": "C2754322", "aliases": ["ITGA4-ITGB1-CB47 complex", "alpha4-beta1 integrin-CD47 complex location", "ITGA4-ITGB1-CB47 complex location"], "types": ["T026"], "canonical_name": "alpha4-beta1 integrin-CD47 complex", "definition": "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47. [PMID:15292185]"}
{"concept_id": "C2754323", "aliases": ["ITGA9-ITGB1-FIGF complex location", "alpha9-beta1 integrin-VEGF-D complex location", "ITGA9-ITGB1-FIGF complex"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-VEGF-D complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D. [PMID:15590642]"}
{"concept_id": "C2754324", "aliases": ["ITGA9-ITGB1-VEGFA complex", "ITGA9-ITGB1-VEGFA complex location", "alpha9-beta1 integrin-VEGF-A complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-VEGF-A complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A. [PMID:17363377]"}
{"concept_id": "C2754325", "aliases": ["ITGA9-ITGB1-VEGFC complex", "ITGA9-ITGB1-VEGFC complex location", "alpha9-beta1 integrin-VEGF-C complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-VEGF-C complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C. [PMID:15590642]"}
{"concept_id": "C2754326", "aliases": ["ITGA1-ITGB1-PTPN2 complex location", "ITGA1-ITGB1-PTPN2 complex", "alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex location"], "types": ["T026"], "canonical_name": "alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex", "definition": "A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2. [PMID:15592458]"}
{"concept_id": "C2754327", "aliases": ["ITGAV-ITGB3-EGFR complex location", "ITGAV-ITGB3-EGFR complex", "alphaV-beta3 integrin-EGFR complex location"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-EGFR complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor. [PMID:15834425]"}
{"concept_id": "C2754328", "aliases": ["ITGAV-ITGB6-SPP1 complex", "ITGAV-ITGB6-SPP1 complex location", "alphaV-beta6 integrin-osteopontin complex location"], "types": ["T026"], "canonical_name": "alphaV-beta6 integrin-osteopontin complex", "definition": "A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin. [PMID:16005200]"}
{"concept_id": "C2754329", "aliases": ["ITGA9-ITGB1-SPP1 complex", "alpha9-beta1 integrin-osteopontin complex location", "ITGA9-ITGB1-SPP1 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-osteopontin complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin. [PMID:16005200]"}
{"concept_id": "C2754330", "aliases": ["ITGA5-ITGB1-SPP1 complex location", "ITGA5-ITGB1-SPP1 complex", "alpha5-beta1 integrin-osteopontin complex location"], "types": ["T026"], "canonical_name": "alpha5-beta1 integrin-osteopontin complex", "definition": "A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin. [PMID:16005200]"}
{"concept_id": "C2754331", "aliases": ["ITGAV-ITGB3-PPAP2B complex location", "alphaV-beta3 integrin-LPP3 complex location", "ITGAV-ITGB3-PPAP2B complex"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-LPP3 complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3. [PMID:16099422]"}
{"concept_id": "C2754332", "aliases": ["ITGA5-ITGB1-PPAP2B complex", "alpha5-beta1 integrin-LPP3 complex location", "ITGA5-ITGB1-PPAP2B complex location"], "types": ["T026"], "canonical_name": "alpha5-beta1 integrin-LPP3 complex", "definition": "A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3. [PMID:16099422]"}
{"concept_id": "C2754333", "aliases": ["ITGAV-ITGB3-LAMA4 complex", "alphaV-beta3 integrin-laminin alpha-4 complex location", "ITGAV-ITGB3-LAMA4 complex location"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-laminin alpha-4 complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4. [PMID:16824487]"}
{"concept_id": "C2754334", "aliases": ["ITGAX-ITGB2-ICAM4 complex location", "alphaX-beta2 integrin-ICAM-4 complex location", "ITGAX-ITGB2-ICAM4 complex"], "types": ["T026"], "canonical_name": "alphaX-beta2 integrin-ICAM-4 complex", "definition": "A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4. [PMID:16985175]"}
{"concept_id": "C2754335", "aliases": ["alpha9-beta1 integrin-ADAM8 complex location", "ITGA9-ITGB1-ADAM8 complex", "ITGA9-ITGB1-ADAM8 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-ADAM8 complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8. [PMID:16995821]"}
{"concept_id": "C2754336", "aliases": ["ITGA9-ITGB1-THBS1 complex location", "ITGA9-ITGB1-THBS1 complex", "alpha9-beta1 integrin-thrombospondin-1 complex location"], "types": ["T026"], "canonical_name": "alpha9-beta1 integrin-thrombospondin-1 complex", "definition": "A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1. [PMID:17413041]"}
{"concept_id": "C2754337", "aliases": ["alpha7-beta1 integrin-focal adhesion kinase complex location", "ITGA7-ITGB1-PTK2 complex location", "ITGA7-ITGB1-PTK2 complex"], "types": ["T026"], "canonical_name": "alpha7-beta1 integrin-focal adhesion kinase complex", "definition": "A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase. [PMID:17598176]"}
{"concept_id": "C2754338", "aliases": ["ITGA7-ITGB1-LAMA2 complex", "alpha7-beta1 integrin-laminin alpha-2 complex location", "ITGA7-ITGB1-LAMA2 complex location"], "types": ["T026"], "canonical_name": "alpha7-beta1 integrin-laminin alpha-2 complex", "definition": "A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2. [PMID:17598176]"}
{"concept_id": "C2754339", "aliases": ["ITGAV-ITGB3-SLC3A2 complex location", "alphaV-beta3 integrin-CD98 complex location", "ITGAV-ITGB3-SLC3A2 complex"], "types": ["T026"], "canonical_name": "alphaV-beta3 integrin-CD98 complex", "definition": "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98. [PMID:18032696]"}
{"concept_id": "C2754340", "aliases": ["alpha5-beta5-fibronectin-SFRP2 complex location", "ITGA5-ITGB5-FN-1-SFRP2 complex", "ITGA5-ITGB5-FN-1-SFRP2 complex location"], "types": ["T026"], "canonical_name": "alpha5-beta5-fibronectin-SFRP2 complex", "definition": "A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2. [PMID:14709558]"}
{"concept_id": "C2754341", "aliases": [], "types": ["T045"], "canonical_name": "resolution of recombination intermediates", "definition": "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged. [GOC:elh, GOC:mah, GOC:vw]"}
{"concept_id": "C2754342", "aliases": [], "types": ["T045"], "canonical_name": "resolution of mitotic recombination intermediates", "definition": "The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged. [GOC:elh, GOC:mah, GOC:vw]"}
{"concept_id": "C2754343", "aliases": ["SMAD complex location", "SMAD protein complex location", "SMAD complex"], "types": ["T026"], "canonical_name": "SMAD protein complex", "definition": "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven. [GOC:bhm, GOC:mah, PMID:9670020]"}
{"concept_id": "C2754344", "aliases": ["SMAD2 protein complex location", "SMAD2 homotrimer complex location", "SMAD2 homotrimer complex"], "types": ["T026"], "canonical_name": "SMAD2 protein complex"}
{"concept_id": "C2754346", "aliases": ["heteromeric SMAD protein complex location"], "types": ["T026"], "canonical_name": "heteromeric SMAD protein complex", "definition": "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric. [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]"}
{"concept_id": "C2754354", "aliases": ["G-protein alpha(q)-synembrin complex location", "Ric-8A G(q) alpha subunit complex location", "Ric-8A G(q) alpha subunit complex"], "types": ["T026"], "canonical_name": "G-protein alpha(q)-synembrin complex", "definition": "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein. [GOC:mah, PMID:12509430]"}
{"concept_id": "C2754355", "aliases": ["Ric-8A G(o) alpha-2 subunit complex", "Ric-8A G(o) alpha-1 subunit complex", "G-protein alpha(o)-synembrin complex location", "Ric-8A G(o) alpha-2 subunit complex location", "Ric-8A G(o) alpha-1 subunit complex location"], "types": ["T026"], "canonical_name": "G-protein alpha(o)-synembrin complex", "definition": "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein. [GOC:mah, PMID:12509430]"}
{"concept_id": "C2754356", "aliases": ["Ric-8A G(i) alpha-2 subunit complex", "G-protein alpha(i)1-synembrin complex location", "Ric-8A G(i) alpha-2 subunit complex location", "Ric-8A G(i) alpha-1 subunit complex location", "Ric-8A G(i) alpha-1 subunit complex"], "types": ["T026"], "canonical_name": "G-protein alpha(i)1-synembrin complex", "definition": "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein. [GOC:mah, PMID:12509430]"}
{"concept_id": "C2754357", "aliases": ["Ric-8A G alpha 13 subunit complex location", "G-protein alpha(13)-synembrin complex location", "Ric-8A G alpha 13 subunit complex"], "types": ["T026"], "canonical_name": "G-protein alpha(13)-synembrin complex", "definition": "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein. [GOC:mah, PMID:12509430]"}
{"concept_id": "C2754361", "aliases": ["NF-kappaB complex location"], "types": ["T026"], "canonical_name": "NF-kappaB complex", "definition": "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression. [ISBN:0849327946]"}
{"concept_id": "C2754362", "aliases": [], "types": ["T044"], "canonical_name": "cyanophycin synthetase activity (L-aspartate-adding)", "definition": "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp. [EC:6.3.2.29]"}
{"concept_id": "C2754363", "aliases": [], "types": ["T044"], "canonical_name": "cyanophycin synthetase activity (L-arginine-adding)", "definition": "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1. [EC:6.3.2.30]"}
{"concept_id": "C2754364", "aliases": ["unwindosome", "CMG complex location"], "types": ["T026"], "canonical_name": "CMG complex", "definition": "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. [GOC:rb, PMID:19228417]"}
{"concept_id": "C2754365", "aliases": ["pre-IC complex assembly", "DNA replication preinitiation complex formation"], "types": ["T044"], "canonical_name": "DNA replication preinitiation complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins immediately prior to the initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity. [GOC:mah, PMID:28209641]"}
{"concept_id": "C2754366", "aliases": ["cap hypermethylase activity"], "types": ["T044"], "canonical_name": "RNA trimethylguanosine synthase activity", "definition": "Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine. [GOC:BHF, PMID:11983179, PMID:18775984]"}
{"concept_id": "C2754367", "aliases": ["small nuclear RNA methyltransferase activity", "snRNA methyltransferase activity"], "types": ["T044"], "canonical_name": "snRNA methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule. [PMID:27573892]"}
{"concept_id": "C2754368", "aliases": [], "types": ["T044"], "canonical_name": "GINS complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks. [GOC:mah, PMID:16990792]"}
{"concept_id": "C2754369", "aliases": ["RNP localization", "ribonucleoprotein complex localisation", "cellular ribonucleoprotein complex localization", "establishment and maintenance of ribonucleoprotein complex localization"], "types": ["T043"], "canonical_name": "ribonucleoprotein complex localization", "definition": "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. [GOC:mah]"}
{"concept_id": "C2754371", "aliases": ["protein localisation to chromatin"], "types": ["T043"], "canonical_name": "protein localization to chromatin", "definition": "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. [GOC:mah]"}
{"concept_id": "C2754372", "aliases": ["establishment of protein localisation to chromatin"], "types": ["T043"], "canonical_name": "establishment of protein localization to chromatin", "definition": "The directed movement of a protein to a part of a chromosome that is organized into chromatin. [GOC:mah]"}
{"concept_id": "C2754373", "aliases": [], "types": ["T045"], "canonical_name": "site-specific DNA replication termination", "definition": "A DNA replication termination process that takes place at a specific termination site. [GOC:mah, PMID:12009298, PMID:18723894]"}
{"concept_id": "C2754374", "aliases": [], "types": ["T045"], "canonical_name": "site-specific DNA replication termination at RTS1 barrier", "definition": "A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching. [GOC:vw, PMID:12009298, PMID:18723894]"}
{"concept_id": "C2754375", "aliases": [], "types": ["T044"], "canonical_name": "dihydromonapterin reductase activity", "definition": "Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+. [GOC:imk, PMID:19897652]"}
{"concept_id": "C2754376", "aliases": ["SAC", "signal transduction involved in spindle assembly checkpoint", "spindle assembly checkpoint signaling"], "types": ["T043"], "definition": "A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. [GOC:mah]", "canonical_name": "spindle assembly checkpoint"}
{"concept_id": "C2754377", "aliases": ["MAML2-RBP-Jkappa-ICN1 complex location", "MAML2-RBP-Jkappa-Notch1 complex location", "MAML2-RBP-Jkappa-Notch1 complex"], "types": ["T026"], "canonical_name": "MAML2-RBP-Jkappa-ICN1 complex", "definition": "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. [PMID:12370315]"}
{"concept_id": "C2754378", "aliases": ["MAML2-RBP-Jkappa-ICN2 complex location", "MAML2-RBP-Jkappa-Notch2 complex location", "MAML2-RBP-Jkappa-Notch2 complex"], "types": ["T026"], "canonical_name": "MAML2-RBP-Jkappa-ICN2 complex", "definition": "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. [PMID:12370315]"}
{"concept_id": "C2754379", "aliases": ["MAML2-RBP-Jkappa-ICN3 complex location", "MAML2-RBP-Jkappa-Notch3 complex location", "MAML2-RBP-Jkappa-Notch3 complex"], "types": ["T026"], "canonical_name": "MAML2-RBP-Jkappa-ICN3 complex", "definition": "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. [PMID:12370315]"}
{"concept_id": "C2754380", "aliases": ["MAML2-RBP-Jkappa-Notch4 complex", "MAML2-RBP-Jkappa-Notch4 complex location", "MAML2-RBP-Jkappa-ICN4 complex location"], "types": ["T026"], "canonical_name": "MAML2-RBP-Jkappa-ICN4 complex", "definition": "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. [PMID:12370315]"}
{"concept_id": "C2754381", "aliases": ["MAML3-RBP-Jkappa-Notch1 complex location", "MAML3-RBP-Jkappa-ICN1 complex location", "MAML3-RBP-Jkappa-Notch1 complex"], "types": ["T026"], "canonical_name": "MAML3-RBP-Jkappa-ICN1 complex", "definition": "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. [PMID:12370315]"}
{"concept_id": "C2754382", "aliases": ["MAML3-RBP-Jkappa-Notch2 complex", "MAML3-RBP-Jkappa-ICN2 complex location", "MAML3-RBP-Jkappa-Notch2 complex location"], "types": ["T026"], "canonical_name": "MAML3-RBP-Jkappa-ICN2 complex", "definition": "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. [PMID:12370315]"}
{"concept_id": "C2754383", "aliases": ["MAML3-RBP-Jkappa-ICN3 complex location", "MAML3-RBP-Jkappa-Notch3 complex location", "MAML3-RBP-Jkappa-Notch3 complex"], "types": ["T026"], "canonical_name": "MAML3-RBP-Jkappa-ICN3 complex", "definition": "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. [PMID:12370315]"}
{"concept_id": "C2754384", "aliases": ["MAML3-RBP-Jkappa-Notch4 complex location", "MAML3-RBP-Jkappa-Notch4 complex", "MAML3-RBP-Jkappa-ICN4 complex location"], "types": ["T026"], "canonical_name": "MAML3-RBP-Jkappa-ICN4 complex", "definition": "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. [PMID:12370315]"}
{"concept_id": "C2754385", "aliases": ["protocadherin-alpha-protocadherin-gamma complex location"], "types": ["T026"], "canonical_name": "protocadherin-alpha-protocadherin-gamma complex", "definition": "A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane. [PMID:15347688]"}
{"concept_id": "C2754386", "aliases": ["Pcdhga1-Pcdha4 complex location", "Pcdhga1-Pcdha4 complex", "protocadherin-alpha-v4-protocadherin-gamma-a1 complex location"], "types": ["T026"], "canonical_name": "protocadherin-alpha-v4-protocadherin-gamma-a1 complex", "definition": "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane. [PMID:15347688]"}
{"concept_id": "C2754387", "aliases": ["Pcdhga1-Pcdhga3 complex", "Pcdhga1-Pcdhga3 complex location", "protocadherin-alpha-v4-protocadherin-gamma-a3 complex location"], "types": ["T026"], "canonical_name": "protocadherin-alpha-v4-protocadherin-gamma-a3 complex", "definition": "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane. [PMID:15347688]"}
{"concept_id": "C2754388", "aliases": ["protocadherin-alpha-v4-protocadherin-gamma-b2 complex location", "Pcdhga1-Pcdhgb2 complex", "Pcdhga1-Pcdhgb2 complex location"], "types": ["T026"], "canonical_name": "protocadherin-alpha-v4-protocadherin-gamma-b2 complex", "definition": "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane. [PMID:15347688]"}
{"concept_id": "C2754389", "aliases": ["protocadherin-alpha-v4-protocadherin-gamma-b4 complex location", "Pcdhga1-Pcdhgb4 complex", "Pcdhga1-Pcdhgb4 complex location"], "types": ["T026"], "canonical_name": "protocadherin-alpha-v4-protocadherin-gamma-b4 complex", "definition": "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane. [PMID:15347688]"}
{"concept_id": "C2754390", "aliases": ["Pcdha7-Pcdhga1 complex", "protocadherin-alpha-v7-protocadherin-gamma-a1 complex location", "Pcdha7-Pcdhga1 complex location"], "types": ["T026"], "canonical_name": "protocadherin-alpha-v7-protocadherin-gamma-a1 complex", "definition": "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane. [PMID:15347688]"}
{"concept_id": "C2754391", "aliases": ["protocadherin-alpha-v7-protocadherin-gamma-a3 complex location", "Pcdha7-Pcdhga3 complex", "Pcdha7-Pcdhga3 complex location"], "types": ["T026"], "canonical_name": "protocadherin-alpha-v7-protocadherin-gamma-a3 complex", "definition": "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane. [PMID:15347688]"}
{"concept_id": "C2754392", "aliases": ["Pcdha7-Pcdhgb4 complex", "Pcdha7-Pcdhgb4 complex location", "protocadherin-alpha-v7-protocadherin-gamma-b2 complex location"], "types": ["T026"], "canonical_name": "protocadherin-alpha-v7-protocadherin-gamma-b2 complex", "definition": "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane. [PMID:15347688]"}
{"concept_id": "C2754393", "aliases": ["protocadherin-alpha-v7-protocadherin-gamma-b4 complex location", "Pcdha7-Pcdhgb2 complex location", "Pcdha7-Pcdhgb2 complex"], "types": ["T026"], "canonical_name": "protocadherin-alpha-v7-protocadherin-gamma-b4 complex", "definition": "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane. [PMID:15347688]"}
{"concept_id": "C2754394", "aliases": ["Kv4.2-KChIP1 channel complex location"], "types": ["T026"], "canonical_name": "Kv4.2-KChIP1 channel complex", "definition": "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2. [PMID:15356203]"}
{"concept_id": "C2754395", "aliases": ["Kv4.2-KChIP2 channel complex location"], "types": ["T026"], "canonical_name": "Kv4.2-KChIP2 channel complex", "definition": "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2. [PMID:15356203]"}
{"concept_id": "C2754396", "aliases": ["Kv4.2-KChIP3 channel complex location"], "types": ["T026"], "canonical_name": "Kv4.2-KChIP3 channel complex", "definition": "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2. [PMID:15356203]"}
{"concept_id": "C2754397", "aliases": ["Kv4.2-KChIP4 channel complex location"], "types": ["T026"], "canonical_name": "Kv4.2-KChIP4 channel complex", "definition": "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2. [PMID:15356203]"}
{"concept_id": "C2754398", "aliases": ["Kv4.3-KChIP1 channel complex location"], "types": ["T026"], "canonical_name": "Kv4.3-KChIP1 channel complex", "definition": "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3. [PMID:15356203]"}
{"concept_id": "C2754399", "aliases": ["Kv4.2-Kv4.3 channel complex location"], "types": ["T026"], "canonical_name": "Kv4.2-Kv4.3 channel complex", "definition": "A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3. [PMID:15356203]"}
{"concept_id": "C2754400", "aliases": ["Kv4.1-DPP6 channel complex location", "Kv4.1-DPPX channel complex", "Kv4.1-DPPX channel complex location"], "types": ["T026"], "canonical_name": "Kv4.1-DPP6 channel complex", "definition": "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1. [PMID:15911355]"}
{"concept_id": "C2754401", "aliases": ["Kv4.1-DPPY channel complex", "Kv4.1-DPPY channel complex location", "Kv4.1-DPP10 channel complex location"], "types": ["T026"], "canonical_name": "Kv4.1-DPP10 channel complex", "definition": "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1. [PMID:15911355]"}
{"concept_id": "C2754402", "aliases": ["Kv4.2-DPPX channel complex", "Kv4.2-DPP6 channel complex location", "Kv4.2-DPPX channel complex location"], "types": ["T026"], "canonical_name": "Kv4.2-DPP6 channel complex", "definition": "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2. [PMID:12575952, PMID:15911355]"}
{"concept_id": "C2754403", "aliases": ["Kv4.3-DPPX channel complex location", "Kv4.3-DPPX channel complex", "Kv4.3-DPP6 channel complex location"], "types": ["T026"], "canonical_name": "Kv4.3-DPP6 channel complex", "definition": "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3. [PMID:12575952, PMID:15911355]"}
{"concept_id": "C2754404", "aliases": ["Kv4.3-DPPY channel complex", "Kv4.3-DPPY channel complex location", "Kv4.3-DPP10 channel complex location"], "types": ["T026"], "canonical_name": "Kv4.3-DPP10 channel complex", "definition": "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3. [PMID:15911355]"}
{"concept_id": "C2754405", "aliases": ["WASH complex location"], "types": ["T026"], "canonical_name": "WASH complex", "definition": "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. [GOC:sp, PMID:19922875]"}
{"concept_id": "C2754406", "aliases": ["histone pre-mRNA 3'end processing complex location", "histone 3'end pre-mRNA complex", "histone 3'end pre-mRNA complex location"], "types": ["T026"], "canonical_name": "histone pre-mRNA 3'end processing complex", "definition": "A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1. [GOC:mah, PMID:19470752]"}
{"concept_id": "C2754407", "aliases": ["protein localisation to juxtaparanode region of axon"], "types": ["T043"], "canonical_name": "protein localization to juxtaparanode region of axon", "definition": "Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754408", "aliases": ["establishment of protein localisation to juxtaparanode region of axon"], "types": ["T043"], "canonical_name": "establishment of protein localization to juxtaparanode region of axon", "definition": "The directed movement of a protein to the juxtaparanode region of an axon. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754409", "aliases": [], "types": ["T045"], "canonical_name": "histone pre-mRNA stem-loop binding", "definition": "Binding to a conserved stem-loop structure found in histone pre-mRNAs. [PMID:19470752]"}
{"concept_id": "C2754410", "aliases": [], "types": ["T045"], "canonical_name": "histone pre-mRNA DCP binding", "definition": "Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing. [PMID:19470752]"}
{"concept_id": "C2754411", "aliases": [], "types": ["T045"], "canonical_name": "U7 snRNA binding", "definition": "Binding to a U7 small nuclear RNA (U7 snRNA). [GOC:mah, PMID:12975319]"}
{"concept_id": "C2754412", "aliases": ["establishment of protein localization to membrane raft"], "types": ["T043"], "canonical_name": "protein insertion into membrane raft", "definition": "The process in which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. [GOC:mah]"}
{"concept_id": "C2754413", "aliases": [], "types": ["T044"], "canonical_name": "protein targeting to vacuole involved in autophagy", "definition": "The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm. [GOC:mah]"}
{"concept_id": "C2754414", "aliases": ["subsynaptic reticulum"], "types": ["T026"], "definition": "An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane. [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331]", "canonical_name": "SSR"}
{"concept_id": "C2754415", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to 1-aminocyclopropane-1-carboxylic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus. [GOC:mah]"}
{"concept_id": "C2754416", "aliases": ["cellular response to abiotic stress"], "types": ["T043"], "canonical_name": "cellular response to abiotic stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. [GOC:mah]"}
{"concept_id": "C2754417", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to abscisic acid stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. [GOC:mah]"}
{"concept_id": "C2754418", "aliases": ["cellular response to biotic stress"], "types": ["T043"], "canonical_name": "cellular response to biotic stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. [GOC:mah]"}
{"concept_id": "C2754419", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to external biotic stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. [GOC:mah]"}
{"concept_id": "C2754420", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to misfolded protein", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. [GOC:mah]"}
{"concept_id": "C2754421", "aliases": ["cellular response to bacterium associated molecule", "cellular response to bacterial associated molecule", "cellular response to bacteria associated molecule"], "types": ["T043"], "canonical_name": "cellular response to molecule of bacterial origin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. [GOC:mah]"}
{"concept_id": "C2754422", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to bacterial lipoprotein", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus. [GOC:mah]"}
{"concept_id": "C2754423", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to bacterial lipopeptide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus. [GOC:mah]"}
{"concept_id": "C2754424", "aliases": ["cellular response to LPS", "cellular response to endotoxin"], "types": ["T043"], "canonical_name": "cellular response to lipopolysaccharide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]"}
{"concept_id": "C2754425", "aliases": ["cellular response to LTA"], "types": ["T043"], "canonical_name": "cellular response to lipoteichoic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. [GOC:mah]"}
{"concept_id": "C2754426", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to peptidoglycan", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. [GOC:mah]"}
{"concept_id": "C2754427", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to muramyl dipeptide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. [GOC:mah]"}
{"concept_id": "C2754428", "aliases": ["cellular response to fungus associated molecule"], "types": ["T043"], "canonical_name": "cellular response to molecule of fungal origin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide. [GOC:mah]"}
{"concept_id": "C2754429", "aliases": ["cellular response to oomycetes associated molecule"], "types": ["T043"], "canonical_name": "cellular response to molecule of oomycetes origin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin. [GOC:mah]"}
{"concept_id": "C2754430", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to tumor cell", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. [GOC:mah]"}
{"concept_id": "C2754431", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to acid"}
{"concept_id": "C2754432", "aliases": ["cellular response to amino acid"], "types": ["T043"], "canonical_name": "cellular response to amino acid stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:mah]"}
{"concept_id": "C2754433", "aliases": ["response to vitamin B9", "response to folate"], "types": ["T043"], "canonical_name": "cellular response to folic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. [GOC:mah]"}
{"concept_id": "C2754434", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to histidine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus. [GOC:mah]"}
{"concept_id": "C2754435", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to leucine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus. [GOC:mah]"}
{"concept_id": "C2754436", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to phenylalanine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus. [GOC:mah]"}
{"concept_id": "C2754437", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to proline", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus. [GOC:mah]"}
{"concept_id": "C2754438", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to antibiotic", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. [GOC:mah]"}
{"concept_id": "C2754439", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to bacteriocin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation. [GOC:mah]"}
{"concept_id": "C2754440", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to brefeldin A", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus. [GOC:mah]"}
{"concept_id": "C2754441", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to streptomycin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. [GOC:mah]"}
{"concept_id": "C2754442", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to food", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. [GOC:mah]"}
{"concept_id": "C2754443", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to inorganic substance", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:mah]"}
{"concept_id": "C2754444", "aliases": ["cellular response to ammonia"], "types": ["T043"], "canonical_name": "cellular response to ammonium ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23509267]"}
{"concept_id": "C2754445", "aliases": ["cellular response to arsenic"], "types": ["T043"], "canonical_name": "cellular response to arsenic-containing substance", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. [GOC:mah]"}
{"concept_id": "C2754446", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to carbon dioxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus. [GOC:mah]"}
{"concept_id": "C2754447", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to carbon monoxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus. [GOC:mah]"}
{"concept_id": "C2754448", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chlorate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus. [GOC:mah]"}
{"concept_id": "C2754449", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chromate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus. [GOC:mah]"}
{"concept_id": "C2754450", "aliases": ["cellular response to metal", "cellular response to heavy metal"], "types": ["T043"], "canonical_name": "cellular response to metal ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. [GOC:mah]"}
{"concept_id": "C2754451", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nitrate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus. [GOC:mah]"}
{"concept_id": "C2754452", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nitrite", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus. [GOC:mah]"}
{"concept_id": "C2754453", "aliases": ["cellular response to silica", "cellular response to silox"], "types": ["T043"], "canonical_name": "cellular response to silicon dioxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus. [GOC:mah]"}
{"concept_id": "C2754454", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to sulfur dioxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus. [GOC:mah]"}
{"concept_id": "C2754455", "aliases": [], "types": ["T044"], "canonical_name": "connexin binding", "definition": "Binding to a connexin, any of a group of related proteins that assemble to form gap junctions. [GOC:mah, PMID:19864490]"}
{"concept_id": "C2754456", "aliases": ["U body", "cytoplasmic U snRNP body location", "U-body"], "types": ["T026"], "canonical_name": "cytoplasmic U snRNP body", "definition": "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies. [GOC:sart, PMID:17595295]"}
{"concept_id": "C2754457", "aliases": ["cytoplasm-to-vacuole targetin vesicle assembly", "cytoplasm to vacuole targeting vesicle assembly", "Cvt vesicle formation", "Cvt vesicle biosynthesis"], "types": ["T043"], "canonical_name": "Cvt vesicle assembly", "definition": "A vesicle organization process that takes place as part of the Cvt pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI). [GOC:rb, PMID:10966461, PMID:11085977]"}
{"concept_id": "C2754458", "aliases": ["cellular response to electricity"], "types": ["T043"], "canonical_name": "cellular response to electrical stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. [GOC:mah]"}
{"concept_id": "C2754459", "aliases": ["cellular response to gravitational stimulus"], "types": ["T043"], "canonical_name": "cellular response to gravity", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. [GOC:mah]"}
{"concept_id": "C2754460", "aliases": ["cellular response to magnetic stimulus"], "types": ["T043"], "canonical_name": "cellular response to magnetism", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus. [GOC:mah]"}
{"concept_id": "C2754461", "aliases": ["cellular mechanical stimulus response"], "types": ["T043"], "canonical_name": "cellular response to mechanical stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:mah]"}
{"concept_id": "C2754462", "aliases": ["Ssh1p-Sss1p-Sbh2p complex location", "Ssh1 translocon complex location", "Ssh1p-Sss1p-Sbh2p complex"], "types": ["T026"], "canonical_name": "Ssh1 translocon complex", "definition": "A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences. [GOC:mah, PMID:12134063, PMID:8612571]"}
{"concept_id": "C2754463", "aliases": ["regulation of translational initiation in response to nutrient starvation"], "types": ["T045"], "canonical_name": "regulation of translational initiation in response to starvation", "definition": "Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment. [GOC:mah]"}
{"concept_id": "C2754464", "aliases": ["inhibition of translation initiation in response to starvation", "down regulation of translation initiation in response to starvation", "down-regulation of translation initiation in response to starvation", "downregulation of translation initiation in response to starvation", "negative regulation of translational initiation in response to nutrient starvation"], "types": ["T045"], "canonical_name": "negative regulation of translational initiation in response to starvation", "definition": "Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment. [GOC:mah]"}
{"concept_id": "C2754465", "aliases": ["up-regulation of translation initiation in response to starvation", "activation of translation initiation in response to starvation", "stimulation of translation initiation in response to starvation", "positive regulation of translational initiation in response to nutrient starvation", "upregulation of translation initiation in response to starvation", "up regulation of translation initiation in response to starvation"], "types": ["T045"], "canonical_name": "positive regulation of translational initiation in response to starvation", "definition": "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment. [GOC:mah]"}
{"concept_id": "C2754466", "aliases": ["L-methionine anabolism", "L-methionine synthesis", "L-methionine formation", "L-methionine biosynthesis"], "types": ["T044"], "canonical_name": "L-methionine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid. [GOC:ecd]"}
{"concept_id": "C2754467", "aliases": ["'de novo' L-methionine anabolism", "'de novo' L-methionine formation", "'de novo' L-methionine synthesis", "'de novo' L-methionine biosynthesis"], "types": ["T044"], "canonical_name": "'de novo' L-methionine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components. [GOC:ecd]"}
{"concept_id": "C2754468", "aliases": [], "types": ["T044"], "canonical_name": "L-methionine salvage", "definition": "Any process that generates L-methionine from derivatives of it, without de novo synthesis. [GOC:ecd]"}
{"concept_id": "C2754469", "aliases": ["homocysteine anabolism", "homocysteine formation", "homocysteine synthesis", "homocysteine biosynthesis"], "types": ["T044"], "canonical_name": "homocysteine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid. [GOC:ecd, GOC:mah]"}
{"concept_id": "C2754470", "aliases": ["L-homocysteine biosynthesis", "L-homocysteine synthesis", "L-homocysteine formation", "L-homocysteine anabolism"], "types": ["T044"], "canonical_name": "L-homocysteine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-homocysteine, the L-enantiomer of 2-amino-4-sulfanylbutanoic acid. [GOC:ecd, GOC:mah]"}
{"concept_id": "C2754471", "aliases": ["1-butanol metabolism", "butan-1-ol metabolic process", "butanol metabolic process"], "types": ["T044"], "canonical_name": "1-butanol metabolic process", "definition": "The chemical reactions and pathways involving 1-butanol, an alkyl primary alcohol with the formula C4H10O. [GOC:ecd, GOC:mah]"}
{"concept_id": "C2754472", "aliases": ["1-butanol anabolism", "1-butanol synthesis", "1-butanol biosynthesis", "butanol biosynthetic process", "butan-1-ol biosynthetic process", "1-butanol formation"], "types": ["T044"], "canonical_name": "1-butanol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O. [GOC:ecd, GOC:mah]"}
{"concept_id": "C2754473", "aliases": ["morphine metabolism"], "types": ["T044"], "canonical_name": "morphine metabolic process", "definition": "The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum. [GOC:mah]"}
{"concept_id": "C2754474", "aliases": ["morphine breakdown", "morphine catabolism", "morphine degradation"], "types": ["T044"], "canonical_name": "morphine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum. [GOC:ecd, GOC:mah]"}
{"concept_id": "C2754475", "aliases": ["ipecac alkaloid catabolism", "isoquinoline alkaloid degradation", "isoquinoline alkaloid breakdown", "isoquinoline alkaloid catabolism"], "types": ["T044"], "canonical_name": "isoquinoline alkaloid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html]"}
{"concept_id": "C2754476", "aliases": ["cellular response to aluminum", "cellular response to aluminium ion"], "types": ["T043"], "canonical_name": "cellular response to aluminum ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus. [GOC:mah]"}
{"concept_id": "C2754477", "aliases": ["cellular response to cadmium"], "types": ["T043"], "canonical_name": "cellular response to cadmium ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. [GOC:mah]"}
{"concept_id": "C2754478", "aliases": ["cellular response to Ca2+ ion"], "types": ["T043"], "canonical_name": "cellular response to calcium ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:mah]"}
{"concept_id": "C2754479", "aliases": ["cellular response to cesium"], "types": ["T043"], "canonical_name": "cellular response to cesium ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus. [GOC:mah]"}
{"concept_id": "C2754480", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cobalt ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. [GOC:mah]"}
{"concept_id": "C2754481", "aliases": ["cellular response to copper"], "types": ["T043"], "canonical_name": "cellular response to copper ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. [GOC:mah]"}
{"concept_id": "C2754482", "aliases": ["cellular response to iron"], "types": ["T043"], "canonical_name": "cellular response to iron ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. [GOC:mah]"}
{"concept_id": "C2754483", "aliases": ["cellular response to iron(II)"], "types": ["T043"], "canonical_name": "cellular response to iron(II) ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. [GOC:mah]"}
{"concept_id": "C2754484", "aliases": ["cellular response to iron(III)"], "types": ["T043"], "canonical_name": "cellular response to iron(III) ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus. [GOC:mah]"}
{"concept_id": "C2754485", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to lead ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. [GOC:mah]"}
{"concept_id": "C2754486", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to lithium ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. [GOC:mah]"}
{"concept_id": "C2754487", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to magnesium ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah]"}
{"concept_id": "C2754488", "aliases": ["cellular response to manganese"], "types": ["T043"], "canonical_name": "cellular response to manganese ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. [GOC:mah]"}
{"concept_id": "C2754489", "aliases": ["cellular response to mercury", "cellular response to mercuric ion"], "types": ["T043"], "canonical_name": "cellular response to mercury ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. [GOC:mah]"}
{"concept_id": "C2754490", "aliases": ["cellular response to nickel"], "types": ["T043"], "canonical_name": "cellular response to nickel ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus. [GOC:mah]"}
{"concept_id": "C2754491", "aliases": ["cellular response to platinum"], "types": ["T043"], "canonical_name": "cellular response to platinum ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus. [GOC:mah]"}
{"concept_id": "C2754492", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to selenium ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion. [GOC:mah]"}
{"concept_id": "C2754493", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to silver ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus. [GOC:mah]"}
{"concept_id": "C2754494", "aliases": ["cellular response to tellurium"], "types": ["T043"], "canonical_name": "cellular response to tellurium ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus. [GOC:mah]"}
{"concept_id": "C2754495", "aliases": ["cellular response to zinc"], "types": ["T043"], "canonical_name": "cellular response to zinc ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. [GOC:mah]"}
{"concept_id": "C2754496", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to vitamin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. [GOC:mah]"}
{"concept_id": "C2754497", "aliases": ["cellular response to vitamin B7", "cellular response to Bios IIB", "cellular response to vitamin H", "cellular response to coenzyme R"], "types": ["T043"], "canonical_name": "cellular response to biotin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus. [GOC:mah]"}
{"concept_id": "C2754498", "aliases": ["cellular response to vitamin B12"], "types": ["T043"], "canonical_name": "cellular response to cobalamin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus. [GOC:mah]"}
{"concept_id": "C2754499", "aliases": ["cellular response to vitamin C", "cellular response to ascorbic acid", "cellular response to L-ascorbate"], "types": ["T043"], "canonical_name": "cellular response to L-ascorbic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus. [GOC:mah]"}
{"concept_id": "C2754500", "aliases": ["cellular response to retinol"], "types": ["T043"], "canonical_name": "cellular response to vitamin A", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. [GOC:mah]"}
{"concept_id": "C2754501", "aliases": ["cellular response to vitamin A acid"], "types": ["T043"], "canonical_name": "cellular response to retinoic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:mah]"}
{"concept_id": "C2754502", "aliases": ["cellular response to thiamine", "cellular response to thiamin"], "types": ["T043"], "canonical_name": "cellular response to vitamin B1", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus. [GOC:mah]"}
{"concept_id": "C2754503", "aliases": ["cellular response to riboflavin"], "types": ["T043"], "canonical_name": "cellular response to vitamin B2", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus. [GOC:mah]"}
{"concept_id": "C2754504", "aliases": ["cellular response to nicotinamide", "cellular response to niacin"], "types": ["T043"], "canonical_name": "cellular response to vitamin B3", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus. [GOC:mah]"}
{"concept_id": "C2754505", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to vitamin B6", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. [GOC:mah]"}
{"concept_id": "C2754506", "aliases": ["cellular response to ergocalciferol", "cellular response to cholecalciferol", "cellular response to calciferol"], "types": ["T043"], "canonical_name": "cellular response to vitamin D", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. [GOC:mah]"}
{"concept_id": "C2754507", "aliases": ["cellular response to O-Acetyl-alpha-tocopherol", "cellular response to DL-alpha-tocopheryl acetate", "cellular response to DL-alpha-tocopherol acetate"], "types": ["T043"], "canonical_name": "cellular response to vitamin E", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. [GOC:mah]"}
{"concept_id": "C2754508", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to vitamin K", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus. [GOC:mah]"}
{"concept_id": "C2754509", "aliases": ["cellular response to vitamin K2", "cellular response to menatetrenone"], "types": ["T043"], "canonical_name": "cellular response to menaquinone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus. [GOC:mah]"}
{"concept_id": "C2754510", "aliases": ["cellular response to vitamin K1"], "types": ["T043"], "canonical_name": "cellular response to phylloquinone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus. [GOC:mah]"}
{"concept_id": "C2754511", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to organic substance", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. [GOC:mah]"}
{"concept_id": "C2754512", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to acetate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. [GOC:mah]"}
{"concept_id": "C2754513", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to alkaloid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. [GOC:mah]"}
{"concept_id": "C2754514", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to caffeine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. [GOC:mah]"}
{"concept_id": "C2754515", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cocaine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:mah]"}
{"concept_id": "C2754516", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to morphine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. [GOC:mah]"}
{"concept_id": "C2754517", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nicotine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:mah]"}
{"concept_id": "C2754518", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to isoquinoline alkaloid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. [GOC:mah]"}
{"concept_id": "C2754519", "aliases": ["cellular response to adenosine triphosphate", "cellular response to adenosine 5'-triphosphate"], "types": ["T043"], "canonical_name": "cellular response to ATP", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:mah]"}
{"concept_id": "C2754520", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to benzoic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus. [GOC:mah]"}
{"concept_id": "C2754521", "aliases": ["cellular response to 3',5'-cAMP", "cellular response to cyclic AMP", "cellular response to 3',5' cAMP", "cellular response to adenosine 3',5'-cyclophosphate"], "types": ["T043"], "canonical_name": "cellular response to cAMP", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:mah]"}
{"concept_id": "C2754522", "aliases": ["cellular response to 3',5' cGMP", "cellular response to 3',5'-cGMP", "cellular response to cyclic GMP", "cellular response to guanosine 3',5'-cyclophosphate"], "types": ["T043"], "canonical_name": "cellular response to cGMP", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus. [GOC:mah]"}
{"concept_id": "C2754523", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to carbohydrate stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. [GOC:mah]"}
{"concept_id": "C2754524", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chitin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus. [GOC:mah]"}
{"concept_id": "C2754525", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to disaccharide stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus. [GOC:mah]"}
{"concept_id": "C2754526", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to mannitol stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus. [GOC:mah]"}
{"concept_id": "C2754527", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to monosaccharide stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus. [GOC:mah]"}
{"concept_id": "C2754528", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to trehalose stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus. [GOC:mah]"}
{"concept_id": "C2754529", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to maltose stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus. [GOC:mah]"}
{"concept_id": "C2754530", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to sucrose stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus. [GOC:mah]"}
{"concept_id": "C2754531", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to trehalose-6-phosphate stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus. [GOC:mah]"}
{"concept_id": "C2754532", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to hexose stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. [GOC:mah]"}
{"concept_id": "C2754533", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to fructose stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. [GOC:mah]"}
{"concept_id": "C2754534", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to glucose stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:mah]"}
{"concept_id": "C2754535", "aliases": ["cellular response to L-rhamnose stimulus"], "types": ["T043"], "canonical_name": "cellular response to rhamnose stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus. [GOC:mah]"}
{"concept_id": "C2754536", "aliases": [], "types": ["T043"], "canonical_name": "hair follicle cell proliferation", "definition": "The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population. [GOC:rph, PMID:16086254]"}
{"concept_id": "C2754537", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hair follicle cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of hair follicle cell proliferation. [GOC:mah]"}
{"concept_id": "C2754538", "aliases": ["inhibition of hair follicle cell proliferation", "down-regulation of hair follicle cell proliferation", "down regulation of hair follicle cell proliferation", "downregulation of hair follicle cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of hair follicle cell proliferation", "definition": "Any process that stops, prevents or reduces the rate or extent of hair follicle cell proliferation. [GOC:mah]"}
{"concept_id": "C2754539", "aliases": ["up regulation of hair follicle cell proliferation", "up-regulation of hair follicle cell proliferation", "upregulation of hair follicle cell proliferation", "activation of hair follicle cell proliferation", "stimulation of hair follicle cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of hair follicle cell proliferation", "definition": "Any process that activates or increases the rate or extent of hair follicle cell proliferation. [GOC:mah]"}
{"concept_id": "C2754540", "aliases": ["MLL1 complex location"], "types": ["T026"], "canonical_name": "MLL1 complex", "definition": "A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5. [GOC:sp, PMID:15960975]"}
{"concept_id": "C2754541", "aliases": ["skeletal muscle AChR clustering", "skeletal muscle nicotinic acetylcholine receptor clustering"], "types": ["T043"], "canonical_name": "skeletal muscle acetylcholine-gated channel clustering", "definition": "The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals. [GOC:bf, GOC:dsf, PMID:19285469]"}
{"concept_id": "C2754542", "aliases": ["mid1p medial cortical dot", "midsome"], "types": ["T026"], "canonical_name": "medial cortical node", "definition": "A component of the cell division site that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis. [GOC:mah, GOC:vw, PMID:19474789, PMID:19959363]"}
{"concept_id": "C2754543", "aliases": ["regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle", "regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis", "regulation of establishment of contractile ring localization involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "regulation of establishment of actomyosin contractile ring localization", "definition": "Any process that modulates the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location that contributes to cytokinesis during cell cycle. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2754545", "aliases": ["pyrophosphate metabolism"], "types": ["T044"], "canonical_name": "diphosphate metabolic process", "definition": "The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid. [GOC:pde]"}
{"concept_id": "C2754546", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cytokine stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. [GOC:mah]"}
{"concept_id": "C2754547", "aliases": ["cellular response to type II IFN", "cellular response to immune interferon", "cellular response to type II interferon", "cellular response to gamma-interferon"], "types": ["T043"], "canonical_name": "cellular response to interferon-gamma", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. [GOC:mah]"}
{"concept_id": "C2754548", "aliases": ["cellular response to IL-1"], "types": ["T043"], "canonical_name": "cellular response to interleukin-1", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:mah]"}
{"concept_id": "C2754549", "aliases": ["cellular response to IL-11"], "types": ["T043"], "canonical_name": "cellular response to interleukin-11", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus. [GOC:mah]"}
{"concept_id": "C2754550", "aliases": ["cellular response to IL-12"], "types": ["T043"], "canonical_name": "cellular response to interleukin-12", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus. [GOC:mah]"}
{"concept_id": "C2754551", "aliases": ["cellular response to IL-15"], "types": ["T043"], "canonical_name": "cellular response to interleukin-15", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus. [GOC:mah]"}
{"concept_id": "C2754552", "aliases": ["cellular response to IL-18"], "types": ["T043"], "canonical_name": "cellular response to interleukin-18", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus. [GOC:mah]"}
{"concept_id": "C2754553", "aliases": ["cellular response to IL-2"], "types": ["T043"], "canonical_name": "cellular response to interleukin-2", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus. [GOC:mah]"}
{"concept_id": "C2754554", "aliases": ["cellular response to IL-4"], "types": ["T043"], "canonical_name": "cellular response to interleukin-4", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. [GOC:mah]"}
{"concept_id": "C2754555", "aliases": ["cellular response to IL-6"], "types": ["T043"], "canonical_name": "cellular response to interleukin-6", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. [GOC:mah]"}
{"concept_id": "C2754556", "aliases": ["cellular response to IL-9"], "types": ["T043"], "canonical_name": "cellular response to interleukin-9", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus. [GOC:mah]"}
{"concept_id": "C2754557", "aliases": ["cellular response to TNF"], "types": ["T043"], "canonical_name": "cellular response to tumor necrosis factor", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah]"}
{"concept_id": "C2754558", "aliases": ["cellular response to type I IFN"], "types": ["T043"], "canonical_name": "cellular response to type I interferon", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:mah]"}
{"concept_id": "C2754559", "aliases": ["cellular response to interferon-lambda", "cellular response to type III IFN"], "types": ["T043"], "canonical_name": "cellular response to type III interferon", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far. [GOC:mah]"}
{"concept_id": "C2754560", "aliases": ["cellular response to double-stranded RNA"], "types": ["T043"], "canonical_name": "cellular response to dsRNA", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. [GOC:mah]"}
{"concept_id": "C2754561", "aliases": ["cellular response to exogenous double-stranded RNA"], "types": ["T043"], "canonical_name": "cellular response to exogenous dsRNA", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. [GOC:mah]"}
{"concept_id": "C2754562", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to viral dsRNA"}
{"concept_id": "C2754563", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to ethanol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:mah]"}
{"concept_id": "C2754564", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to ether", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. [GOC:mah]"}
{"concept_id": "C2754565", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to growth factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. [GOC:mah]"}
{"concept_id": "C2754566", "aliases": ["cellular response to EGF stimulus"], "types": ["T043"], "canonical_name": "cellular response to epidermal growth factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. [GOC:mah]"}
{"concept_id": "C2754567", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to auxin stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. [GOC:mah]"}
{"concept_id": "C2754568", "aliases": ["cellular response to indole-3-butyric acid stimulus", "cellular response to IBA stimulus"], "types": ["T043"], "canonical_name": "cellular response to indolebutyric acid stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus. [GOC:mah]"}
{"concept_id": "C2754569", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to brassinosteroid stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus. [GOC:mah]"}
{"concept_id": "C2754570", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cytokinin stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus. [GOC:mah]"}
{"concept_id": "C2754571", "aliases": ["cellular response to ethene stimulus"], "types": ["T043"], "canonical_name": "cellular response to ethylene stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. [GOC:mah]"}
{"concept_id": "C2754572", "aliases": ["cellular response to gibberellic acid stimulus"], "types": ["T043"], "canonical_name": "cellular response to gibberellin stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus. [GOC:mah]"}
{"concept_id": "C2754573", "aliases": ["cellular response to gonadotrophin stimulus"], "types": ["T043"], "canonical_name": "cellular response to gonadotropin stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. [GOC:mah]"}
{"concept_id": "C2754574", "aliases": ["cellular response to follicle stimulating hormone stimulus", "cellular response to FSH stimulus"], "types": ["T043"], "canonical_name": "cellular response to follicle-stimulating hormone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. [GOC:mah]"}
{"concept_id": "C2754575", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to luteinizing hormone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. [GOC:mah]"}
{"concept_id": "C2754576", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to parathyroid hormone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. [GOC:mah]"}
{"concept_id": "C2754577", "aliases": ["cellular response to polypeptide hormone stimulus"], "types": ["T043"], "canonical_name": "cellular response to peptide hormone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [GOC:mah]"}
{"concept_id": "C2754578", "aliases": ["cellular response to corticotropin-releasing factor stimulus", "cellular response to CRH stimulus", "cellular response to CRF stimulus", "cellular response to corticoliberin stimulus"], "types": ["T043"], "canonical_name": "cellular response to corticotropin-releasing hormone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response. [GOC:mah]"}
{"concept_id": "C2754579", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to glucagon stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. [GOC:mah]"}
{"concept_id": "C2754580", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to growth hormone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. [GOC:mah]"}
{"concept_id": "C2754581", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to prostaglandin stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. [GOC:mah]"}
{"concept_id": "C2754582", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to prostaglandin E stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. [GOC:mah]"}
{"concept_id": "C2754583", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to prostaglandin F stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus. [GOC:mah]"}
{"concept_id": "C2754584", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to prostaglandin I stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus. [GOC:mah]"}
{"concept_id": "C2754585", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to steroid hormone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. [GOC:mah]"}
{"concept_id": "C2754586", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to corticosteroid stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. [GOC:mah]"}
{"concept_id": "C2754587", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to glucocorticoid stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:mah]"}
{"concept_id": "C2754588", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to corticosterone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. [GOC:mah]"}
{"concept_id": "C2754589", "aliases": ["cellular response to hydrocortisone stimulus"], "types": ["T043"], "canonical_name": "cellular response to cortisol stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions. [GOC:mah]"}
{"concept_id": "C2754590", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cortisone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues. [GOC:mah]"}
{"concept_id": "C2754591", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to mineralocorticoid stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. [GOC:mah]"}
{"concept_id": "C2754592", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to ecdysone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus. [GOC:mah]"}
{"concept_id": "C2754593", "aliases": ["cellular response to oestrogen stimulus"], "types": ["T043"], "canonical_name": "cellular response to estrogen stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:mah]"}
{"concept_id": "C2754594", "aliases": ["cellular response to E2 stimulus"], "types": ["T043"], "canonical_name": "cellular response to estradiol stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah]"}
{"concept_id": "C2754595", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to progesterone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. [GOC:mah]"}
{"concept_id": "C2754596", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to testosterone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. [GOC:mah]"}
{"concept_id": "C2754597", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to jasmonic acid stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. [GOC:mah]"}
{"concept_id": "C2754598", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to lipid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. [GOC:mah]"}
{"concept_id": "C2754599", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cholesterol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. [GOC:mah]"}
{"concept_id": "C2754600", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to fatty acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:mah]"}
{"concept_id": "C2754601", "aliases": ["cellular response to linoleate"], "types": ["T043"], "canonical_name": "cellular response to linoleic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus. [GOC:mah]"}
{"concept_id": "C2754602", "aliases": ["cellular response to oleate"], "types": ["T043"], "canonical_name": "cellular response to oleic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus. [GOC:mah]"}
{"concept_id": "C2754603", "aliases": ["cellular response to triacylglyceride", "cellular response to triacylglycerol"], "types": ["T043"], "canonical_name": "cellular response to triglyceride", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus. [GOC:mah]"}
{"concept_id": "C2754604", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to lipoprotein particle stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. [GOC:mah]"}
{"concept_id": "C2754605", "aliases": ["cellular response to high-density lipoprotein particle stimulus"], "types": ["T043"], "canonical_name": "cellular response to high density lipoprotein particle stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus. [GOC:mah]"}
{"concept_id": "C2754606", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to low-density lipoprotein particle stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. [GOC:mah]"}
{"concept_id": "C2754607", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to methanol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus. [GOC:mah]"}
{"concept_id": "C2754608", "aliases": ["cellular response to MeHg+", "cellular response to CH3-Hg+"], "types": ["T043"], "canonical_name": "cellular response to methylmercury", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. [GOC:mah]"}
{"concept_id": "C2754609", "aliases": ["cellular response to organic cyclic substance"], "types": ["T043"], "canonical_name": "cellular response to organic cyclic compound", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:mah]"}
{"concept_id": "C2754610", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cycloalkane", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n. [GOC:mah]"}
{"concept_id": "C2754611", "aliases": ["cellular response to actidione"], "types": ["T040"], "canonical_name": "cellular response to cycloheximide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes. [GOC:mah]"}
{"concept_id": "C2754612", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cyclopentenone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid. [GOC:mah]"}
{"concept_id": "C2754613", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to fluoxetine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor. [GOC:mah, GOC:pr]"}
{"concept_id": "C2754614", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to genistein", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus. [GOC:mah]"}
{"concept_id": "C2754615", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to hydroxyisoflavone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus. [GOC:mah]"}
{"concept_id": "C2754616", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to methotrexate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase. [GOC:mah]"}
{"concept_id": "C2754617", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to purine"}
{"concept_id": "C2754618", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to tropane", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine. [GOC:mah]"}
{"concept_id": "C2754619", "aliases": ["cellular response to organic nitrogen"], "types": ["T043"], "canonical_name": "cellular response to organonitrogen compound", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. [GOC:mah]"}
{"concept_id": "C2754620", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to amine stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. [GOC:mah]"}
{"concept_id": "C2754621", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to amphetamine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:mah]"}
{"concept_id": "C2754622", "aliases": ["cellular response to histamine stimulus"], "types": ["T043"], "canonical_name": "cellular response to histamine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. [GOC:mah]"}
{"concept_id": "C2754623", "aliases": ["manganese ion membrane transport", "transmembrane manganese transport"], "types": ["T044"], "canonical_name": "manganese ion transmembrane transport", "definition": "A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2754624", "aliases": ["succinate membrane transport", "transmembrane succinate transport"], "types": ["T043"], "canonical_name": "succinate transmembrane transport", "definition": "The process in which succinate is transported across a membrane. [GOC:mah]"}
{"concept_id": "C2754625", "aliases": ["transmembrane malate transport", "malate membrane transport"], "types": ["T043"], "canonical_name": "malate transmembrane transport", "definition": "A process in which a malate ion is transported across a membrane. [GOC:mah]"}
{"concept_id": "C2754626", "aliases": [], "types": ["T044"], "canonical_name": "rRNA (cytosine-N4-)-methyltransferase activity", "definition": "Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. [GOC:imk, PMID:19965768, RHEA:62520]"}
{"concept_id": "C2754627", "aliases": ["hemopoietic stem cell proliferation"], "types": ["T043"], "canonical_name": "hematopoietic stem cell proliferation", "definition": "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl]"}
{"concept_id": "C2754634", "aliases": ["a-factor processing (proteolytic)", "peptide mating pheromone processing involved in conjugation with cellular fusion", "peptide mating pheromone formation involved in conjugation with cellular fusion", "mating-type peptide pheromone maturation involved in conjugation with cellular fusion", "alpha-factor maturation"], "types": ["T044"], "canonical_name": "peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion", "definition": "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion. [GOC:mah]"}
{"concept_id": "C2754635", "aliases": [], "types": ["T043"], "canonical_name": "cell wall repair", "definition": "A process of cell wall organization that results in the restoration of the cell wall following damage. [GOC:mah, GOC:vw]"}
{"concept_id": "C2754636", "aliases": ["angiotensin mediated chemotaxis", "angiotensin-mediated cell chemotaxis"], "types": ["T043"], "canonical_name": "cell chemotaxis to angiotensin", "definition": "The directed movement of a motile cell in response to the presence of angiotensin. [GOC:mah]"}
{"concept_id": "C2754637", "aliases": ["potassium ion export"], "types": ["T043"], "canonical_name": "potassium export"}
{"concept_id": "C2754641", "aliases": ["clathrin complex location", "clathrin triskelion"], "types": ["T026"], "canonical_name": "clathrin complex", "definition": "A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface. [GOC:mah, PMID:16493411]"}
{"concept_id": "C2754642", "aliases": ["regulation of histone H3 acetylation at K14", "regulation of histone H3K14 acetylation"], "types": ["T045"], "canonical_name": "regulation of histone H3-K14 acetylation", "definition": "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone. [GOC:mah]"}
{"concept_id": "C2754643", "aliases": ["negative regulation of histone H3 acetylation at K14", "negative regulation of histone H3K14 acetylation", "down regulation of histone H3-K14 acetylation", "down-regulation of histone H3-K14 acetylation", "downregulation of histone H3-K14 acetylation"], "types": ["T045"], "canonical_name": "negative regulation of histone H3-K14 acetylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone. [GOC:mah]"}
{"concept_id": "C2754644", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of histone H3-K14 acetylation"}
{"concept_id": "C2754645", "aliases": ["positive regulation of histone H3 acetylation at K14", "up regulation of histone H3-K14 acetylation", "upregulation of histone H3-K14 acetylation", "up-regulation of histone H3-K14 acetylation", "positive regulation of histone H3K14 acetylation"], "types": ["T045"], "canonical_name": "positive regulation of histone H3-K14 acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone. [GOC:mah]"}
{"concept_id": "C2754646", "aliases": [], "types": ["T045"], "canonical_name": "activation of histone H3-K14 acetylation"}
{"concept_id": "C2754647", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of histone H3-K14 acetylation"}
{"concept_id": "C2754648", "aliases": [], "types": ["T045"], "canonical_name": "tDNA binding", "definition": "Binding to DNA sequences encoding transfer RNA. [GOC:mah]"}
{"concept_id": "C2754649", "aliases": ["cellular pheromone response"], "types": ["T043"], "canonical_name": "cellular response to pheromone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. [GOC:mah]"}
{"concept_id": "C2754651", "aliases": ["cellular response to salicylate stimulus"], "types": ["T043"], "canonical_name": "cellular response to salicylic acid stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. [GOC:mah]"}
{"concept_id": "C2754652", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to hydroperoxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. [GOC:mah]"}
{"concept_id": "C2754653", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to alkyl hydroperoxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group. [GOC:mah]"}
{"concept_id": "C2754654", "aliases": ["cellular response to LHPO"], "types": ["T043"], "canonical_name": "cellular response to lipid hydroperoxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids. [GOC:mah]"}
{"concept_id": "C2754655", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to oxygen radical", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. [GOC:mah]"}
{"concept_id": "C2754656", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to superoxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. [GOC:mah]"}
{"concept_id": "C2754657", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to singlet oxygen", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst. [GOC:mah]"}
{"concept_id": "C2754658", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to oxygen levels", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. [GOC:mah]"}
{"concept_id": "C2754659", "aliases": ["cellular response to anaerobic conditions", "cellular response to anoxic stress"], "types": ["T043"], "canonical_name": "cellular response to anoxia", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. [GOC:mah]"}
{"concept_id": "C2754660", "aliases": ["cellular response to increased oxygen tension", "cellular response to hyperoxic stress"], "types": ["T043"], "canonical_name": "cellular response to hyperoxia", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. [GOC:mah]"}
{"concept_id": "C2754661", "aliases": ["cellular response to hypoxic stress", "cellular response to lowered oxygen tension"], "types": ["T043"], "canonical_name": "cellular response to hypoxia", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]"}
{"concept_id": "C2754662", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to ozone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus. [GOC:mah]"}
{"concept_id": "C2754663", "aliases": ["integral to cytosolic side of endoplasmic reticulum membrane", "integral to cytosolic side of ER membrane", "integral to ER membrane, cytosolic side", "integral to cytosolic leaflet of endoplasmic reticulum membrane"], "types": ["T026"], "canonical_name": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "definition": "The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C2754664", "aliases": ["protein localisation to chromosome, centromeric region", "protein localization to centromere", "protein localization to chromosome, centric region"], "types": ["T043"], "canonical_name": "protein localization to chromosome, centromeric region", "definition": "Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. [GOC:mah]"}
{"concept_id": "C2754665", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cell-matrix adhesion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion. [GOC:sl, PMID:11425869]"}
{"concept_id": "C2754666", "aliases": ["cellular redox signal response"], "types": ["T043"], "canonical_name": "cellular response to redox state", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. [GOC:mah]"}
{"concept_id": "C2754667", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to water stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. [GOC:mah]"}
{"concept_id": "C2754668", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to humidity", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere. [GOC:mah]"}
{"concept_id": "C2754669", "aliases": ["cellular response to static fluid pressure"], "types": ["T043"], "canonical_name": "cellular response to hydrostatic pressure", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. [GOC:mah]"}
{"concept_id": "C2754670", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to biomechanical stress"}
{"concept_id": "C2754671", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to desiccation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. [GOC:mah]"}
{"concept_id": "C2754672", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to xenobiotic stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:krc, GOC:mah]"}
{"concept_id": "C2754673", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to pH", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:mah, Wikipedia:PH]"}
{"concept_id": "C2754674", "aliases": ["cellular response to acidity"], "types": ["T043"], "canonical_name": "cellular response to acidic pH", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:go_curators, GOC:mah, Wikipedia:PH]"}
{"concept_id": "C2754675", "aliases": ["cellular response to basic pH"], "types": ["T043"], "canonical_name": "cellular response to alkaline pH", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:go_curators, GOC:mah, Wikipedia:PH]"}
{"concept_id": "C2754676", "aliases": ["cellular osmotic response", "cellular osmotic stress response"], "types": ["T043"], "canonical_name": "cellular response to osmotic stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:mah]"}
{"concept_id": "C2754677", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to non-ionic osmotic stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment. [GOC:mah]"}
{"concept_id": "C2754678", "aliases": ["cellular response to salinity", "cellular salinity response", "cellular response to ionic osmotic stress"], "types": ["T043"], "canonical_name": "cellular response to salt stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:mah]"}
{"concept_id": "C2754679", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cation stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment. [GOC:mah]"}
{"concept_id": "C2754680", "aliases": ["cellular hypertonic response", "cellular HOG response", "cellular response to hypertonicity"], "types": ["T043"], "canonical_name": "cellular hyperosmotic response", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. [GOC:mah]"}
{"concept_id": "C2754681", "aliases": ["cellular response to hyperosmotic salt stress"], "types": ["T043"], "canonical_name": "cellular hyperosmotic salinity response", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:mah]"}
{"concept_id": "C2754682", "aliases": ["cellular hypo-osmotic response"], "types": ["T043"], "canonical_name": "cellular hypotonic response", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. [GOC:mah]"}
{"concept_id": "C2754683", "aliases": ["cellular response to hypotonic salt stress"], "types": ["T043"], "canonical_name": "cellular hypotonic salinity response", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:mah]"}
{"concept_id": "C2754684", "aliases": ["cellular response to radiation stimulus", "cellular response to electromagnetic radiation stimulus"], "types": ["T043"], "canonical_name": "cellular response to radiation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. [GOC:mah]"}
{"concept_id": "C2754685", "aliases": ["cellular response to ionizing radiation stimulus", "cellular response to ionising radiation"], "types": ["T043"], "canonical_name": "cellular response to ionizing radiation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. [GOC:mah]"}
{"concept_id": "C2754686", "aliases": ["cellular response to gamma ray", "cellular response to gamma-ray photon"], "types": ["T043"], "canonical_name": "cellular response to gamma radiation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. [GOC:mah]"}
{"concept_id": "C2754687", "aliases": ["cellular response to X-ray radiation stimulus"], "types": ["T043"], "canonical_name": "cellular response to X-ray", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). [GOC:mah]"}
{"concept_id": "C2754688", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to light stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. [GOC:mah]"}
{"concept_id": "C2754689", "aliases": ["cellular response to blue light stimulus"], "types": ["T043"], "canonical_name": "cellular response to blue light", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. [GOC:mah]"}
{"concept_id": "C2754690", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to light intensity", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus. [GOC:mah]"}
{"concept_id": "C2754691", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to absence of light", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli. [GOC:mah]"}
{"concept_id": "C2754692", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to high light intensity", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. [GOC:mah]"}
{"concept_id": "C2754693", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to low light intensity stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2. [GOC:mah]"}
{"concept_id": "C2754694", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to very low light intensity stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec. [GOC:mah]"}
{"concept_id": "C2754695", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to red or far red light", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. [GOC:mah]"}
{"concept_id": "C2754696", "aliases": ["cellular response to far red light stimulus"], "types": ["T043"], "canonical_name": "cellular response to far red light", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. [GOC:mah]"}
{"concept_id": "C2754697", "aliases": ["cellular response to red light stimulus"], "types": ["T043"], "canonical_name": "cellular response to red light", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. [GOC:mah]"}
{"concept_id": "C2754698", "aliases": ["cellular response to UVA light stimulus", "cellular response to UV-A radiation stimulus", "cellular response to UV-A light stimulus", "cellular response to UVA radiation stimulus"], "types": ["T043"], "canonical_name": "cellular response to UV-A", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. [GOC:mah]"}
{"concept_id": "C2754699", "aliases": ["cellular response to UVB radiation stimulus", "cellular response to medium wave ultraviolet radiation stimulus", "cellular response to UV-B radiation stimulus", "cellular response to UV-B light stimulus", "cellular response to UVB light stimulus", "cellular response to medium wave ultraviolet light stimulus"], "types": ["T043"], "canonical_name": "cellular response to UV-B", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. [GOC:mah]"}
{"concept_id": "C2754700", "aliases": ["cellular response to shortwave ultraviolet light stimulus", "cellular response to shortwave ultraviolet radiation stimulus", "cellular response to germicidal ultraviolet radiation stimulus", "cellular response to UVC radiation stimulus", "cellular response to germicidal ultraviolet light stimulus", "cellular response to UV-C light stimulus", "cellular response to UV-C radiation stimulus", "cellular response to UVC light stimulus"], "types": ["T043"], "canonical_name": "cellular response to UV-C", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. [GOC:mah]"}
{"concept_id": "C2754701", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to endogenous stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. [GOC:mah]"}
{"concept_id": "C2754702", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to external stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. [GOC:mah]"}
{"concept_id": "C2754703", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to freezing", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. [GOC:mah]"}
{"concept_id": "C2754704", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to fluid shear stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. [GOC:mah]"}
{"concept_id": "C2754705", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to laminar fluid shear stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. [GOC:mah]"}
{"concept_id": "C2754706", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nitrosative stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. [GOC:mah]"}
{"concept_id": "C2754707", "aliases": ["cellular sterol depletion response"], "types": ["T043"], "canonical_name": "cellular response to sterol depletion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:mah]"}
{"concept_id": "C2754708", "aliases": ["cellular response to thermal stimulus"], "types": ["T043"], "canonical_name": "cellular response to temperature stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. [GOC:mah]"}
{"concept_id": "C2754709", "aliases": [], "types": ["T043"], "canonical_name": "response to heparin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754710", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to heparin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754711", "aliases": ["response to mycophenolate"], "types": ["T043"], "canonical_name": "response to mycophenolic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754712", "aliases": ["cellular response to mycophenolate"], "types": ["T043"], "canonical_name": "cellular response to mycophenolic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754719", "aliases": ["phosphopantothenoylcysteine decarboxylase complex location"], "types": ["T026"], "canonical_name": "phosphopantothenoylcysteine decarboxylase complex", "definition": "A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces. [GOC:jh, PMID:19915539]"}
{"concept_id": "C2754720", "aliases": ["genomic imprinting", "genetic imprinting"], "types": ["T044"], "definition": "The establishment of epigenetic modifications (imprints) during gametogenesis, leading to an asymmetry in the heterochromatin between the maternal and paternal alleles, and differential expression of the corresponding alleles. This asymmetry results from the different epigenetic pathways acting in maternal and paternal gametes. [PMID:31896690]", "canonical_name": "DNA imprinting"}
{"concept_id": "C2754721", "aliases": ["mating type determination, imprinting", "genetic imprinting at mating-type locus", "genomic imprinting at mating-type locus"], "types": ["T045"], "canonical_name": "mating-type locus imprinting", "definition": "A genomic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication. [GOC:mah, PMID:14765111, PMID:18723894]"}
{"concept_id": "C2754724", "aliases": ["4,5-dihydroxy-pentane-2,3-dione kinase activity"], "types": ["T044"], "canonical_name": "autoinducer-2 kinase activity", "definition": "Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP. [GOC:imk, PMID:17274596, PMID:20025244]"}
{"concept_id": "C2754725", "aliases": [], "types": ["T043"], "canonical_name": "actin filament bundle assembly involved in actomyosin contractile ring formation"}
{"concept_id": "C2754726", "aliases": [], "types": ["T043"], "canonical_name": "actin filament bundle convergence involved in actomyosin contractile ring formation"}
{"concept_id": "C2754727", "aliases": ["Ras1-Scd1-Scd2-Cdc42-Shk1 complex", "Ras1-Scd1-Scd2-Cdc42-Shk1 complex location", "Cdc42 GTPase complex location"], "types": ["T026"], "canonical_name": "Cdc42 GTPase complex", "definition": "A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway. [GOC:mah, GOC:vw, PMID:10567532, PMID:7923372, PMID:8943016]"}
{"concept_id": "C2754728", "aliases": [], "types": ["T044"], "canonical_name": "ureidoglycine aminohydrolase activity", "definition": "Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3. [MetaCyc:URUR-RXN, PMID:19935661, PMID:20038185]"}
{"concept_id": "C2754730", "aliases": ["pyrrolysine formation", "pyrrolysine anabolism", "pyrrolysine synthesis", "pyrrolysine biosynthesis", "monomethylamine methyltransferase cofactor lysine adduct biosynthetic process"], "types": ["T044"], "canonical_name": "pyrrolysine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine. [GOC:dh, PMID:17204561]"}
{"concept_id": "C2754731", "aliases": ["pyrrolysine metabolism", "monomethylamine methyltransferase cofactor lysine adduct metabolic process"], "types": ["T044"], "canonical_name": "pyrrolysine metabolic process", "definition": "The chemical reactions and pathways involving pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine. [GOC:mah, PMID:17204561]"}
{"concept_id": "C2754732", "aliases": ["semaphorin-plexin signalling pathway"], "types": ["T044"], "canonical_name": "semaphorin-plexin signaling pathway", "definition": "The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]"}
{"concept_id": "C2754733", "aliases": ["semaphorin-plexin signalling pathway involved in outflow tract morphogenesis"], "types": ["T044"], "canonical_name": "semaphorin-plexin signaling pathway involved in outflow tract morphogenesis", "definition": "The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand that contributes to outflow tract morphogenesis. [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]"}
{"concept_id": "C2754734", "aliases": ["tRNA reexport from nucleus"], "types": ["T043"], "canonical_name": "tRNA re-export from nucleus", "definition": "The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export. [GOC:mcc, PMID:17475781, PMID:20032305]"}
{"concept_id": "C2754735", "aliases": [], "types": ["T042"], "canonical_name": "cementum mineralization", "definition": "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum. [GOC:sl, PMID:17043865]"}
{"concept_id": "C2754738", "aliases": ["ANK repeat binding"], "types": ["T044"], "canonical_name": "ankyrin repeat binding", "definition": "Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure. [GOC:mah, InterPro:IPR002110]"}
{"concept_id": "C2754741", "aliases": [], "types": ["T044"], "canonical_name": "RING-like zinc finger domain binding", "definition": "Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain. [GOC:mah, InterPro:IPR014857]"}
{"concept_id": "C2754745", "aliases": ["protein localisation to centrosome"], "types": ["T043"], "canonical_name": "protein localization to centrosome", "definition": "A process in which a protein is transported to, or maintained at, the centrosome. [GOC:ecd]"}
{"concept_id": "C2754746", "aliases": ["eukaryotic translation initiation factor 3 complex location, eIF3e", "eIF3e-containing eukaryotic translation initiation factor 3 complex", "eIF3e-containing eukaryotic translation initiation factor 3 complex location"], "types": ["T026"], "canonical_name": "eukaryotic translation initiation factor 3 complex, eIF3e", "definition": "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e. [PMID:15904532, PMID:19061185]"}
{"concept_id": "C2754747", "aliases": ["eukaryotic translation initiation factor 3 complex location, eIF3m", "eIF3m-containing eukaryotic translation initiation factor 3 complex", "eIF3m-containing eukaryotic translation initiation factor 3 complex location"], "types": ["T026"], "canonical_name": "eukaryotic translation initiation factor 3 complex, eIF3m", "definition": "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. [PMID:15904532, PMID:19061185]"}
{"concept_id": "C2754748", "aliases": [], "types": ["T043"], "canonical_name": "dopaminergic neuron differentiation", "definition": "The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. [GOC:rph]"}
{"concept_id": "C2754749", "aliases": ["diphosphoinositol polyphosphate metabolism"], "types": ["T044"], "canonical_name": "diphosphoinositol polyphosphate metabolic process", "definition": "The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached. [GOC:mah, PMID:12387729]"}
{"concept_id": "C2754750", "aliases": ["diphosphoinositol polyphosphate degradation", "diphosphoinositol polyphosphate breakdown", "diphosphoinositol polyphosphate catabolism"], "types": ["T044"], "canonical_name": "diphosphoinositol polyphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached. [GOC:mah, PMID:12387729]"}
{"concept_id": "C2754751", "aliases": ["myo-inositol phosphate catabolic process", "inositol phosphate degradation", "inositol phosphate catabolism", "inositol phosphate breakdown"], "types": ["T044"], "canonical_name": "inositol phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:mah]"}
{"concept_id": "C2754752", "aliases": ["intermitochondrial cement"], "types": ["T026"], "canonical_name": "pi-body", "definition": "A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes. [GOC:sp, PMID:20011505]"}
{"concept_id": "C2754753", "aliases": [], "types": ["T026"], "canonical_name": "piP-body", "definition": "A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway. [GOC:sp, PMID:20011505]"}
{"concept_id": "C2754754", "aliases": ["response to dexamethasone stimulus"], "types": ["T043"], "canonical_name": "response to dexamethasone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754755", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to dexamethasone stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754756", "aliases": ["DD-mediated complex assembly", "death-inducing signaling complex formation", "DISC assembly", "DISC formation", "death-inducing signalling complex assembly", "death domain-mediated complex assembly involved in extrinsic apoptotic pathway", "death domain-mediated complex assembly"], "types": ["T044"], "canonical_name": "death-inducing signaling complex assembly", "definition": "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway. [GOC:amm, GOC:mtg_apoptosis, InterPro:IPR000488]"}
{"concept_id": "C2754757", "aliases": ["RHIM binding"], "types": ["T044"], "canonical_name": "RIP homotypic interaction motif binding", "definition": "Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases. [GOC:mah, PMID:11734559]"}
{"concept_id": "C2754759", "aliases": ["G protein coupled pyrimidinergic nucleotide receptor activity", "G-protein coupled pyrimidinergic nucleotide receptor activity", "pyrimidinergic nucleotide receptor activity, G-protein coupled", "pyrimidinergic nucleotide receptor activity, G protein coupled"], "types": ["T044"], "canonical_name": "G protein-coupled pyrimidinergic nucleotide receptor activity", "definition": "Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:sl, PMID:10736418, PMID:12369950, PMID:15796906]"}
{"concept_id": "C2754760", "aliases": ["cellular cell wall organization or biogenesis", "cellular cell wall organisation or biogenesis", "cell wall organisation or biogenesis", "cell wall organization or biogenesis at cellular level"], "types": ["T043"], "canonical_name": "cell wall organization or biogenesis", "definition": "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall. [GOC:mah]"}
{"concept_id": "C2754761", "aliases": ["cell wall organisation in other organism", "cell wall organisation", "cellular cell wall organisation", "cellular cell wall organization", "cell wall organization at cellular level", "cell wall organization in other organism"], "types": ["T043"], "canonical_name": "cell wall organization", "definition": "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. [GOC:mah]"}
{"concept_id": "C2754762", "aliases": ["integral to lumenal side of endoplasmic reticulum membrane", "integral to lumenal leaflet of endoplasmic reticulum membrane", "integral to lumenal side of ER membrane", "integral to ER membrane, lumenal side"], "types": ["T026"], "canonical_name": "integral component of lumenal side of endoplasmic reticulum membrane", "definition": "The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C2754763", "aliases": ["H3K27 demethylation"], "types": ["T044"], "canonical_name": "histone H3-K27 demethylation", "definition": "The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone. [GOC:sp, PMID:20023638]"}
{"concept_id": "C2754764", "aliases": [], "types": ["T044"], "canonical_name": "histone demethylase activity (H3-K27 specific)"}
{"concept_id": "C2754765", "aliases": ["response to transforming growth factor beta stimulus", "response to TGFbeta stimulus", "response to TGF-beta stimulus"], "types": ["T043"], "canonical_name": "response to transforming growth factor beta", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. [GOC:mah]"}
{"concept_id": "C2754766", "aliases": ["cellular response to TGF-beta stimulus", "cellular response to TGFbeta stimulus"], "types": ["T043"], "canonical_name": "cellular response to transforming growth factor beta stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. [GOC:ecd, PMID:15451575]"}
{"concept_id": "C2754767", "aliases": ["nucleus-vacuole membrane contact site", "NVJ", "NV junction"], "types": ["T081"], "canonical_name": "nucleus-vacuole junction", "definition": "An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p. [GOC:jp, PMID:16709156, PMID:16806880]"}
{"concept_id": "C2754768", "aliases": ["NV junction assembly", "nucleus-vacuole junction formation", "NVJ formation", "NVJ assembly", "NV junction formation"], "types": ["T043"], "canonical_name": "nucleus-vacuole junction assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction (NVJ), membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p. The NVJ plays roles in piecemeal microautophagy of the nucleus and in the cytoplasm-to-vacuole targeting pathway. [GOC:jp, PMID:16709156, PMID:28533415]"}
{"concept_id": "C2754769", "aliases": ["Myo2p-Vac17p-Vac8p transport complex location"], "types": ["T026"], "canonical_name": "Myo2p-Vac17p-Vac8p transport complex", "definition": "A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p. [GOC:jp, PMID:12594460]"}
{"concept_id": "C2754770", "aliases": ["npBAF complex location"], "types": ["T026"], "definition": "A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. [GOC:mah, GOC:ss, PMID:17640523]", "canonical_name": "npBAF complex"}
{"concept_id": "C2754771", "aliases": ["nBAF complex"], "types": ["T026"], "definition": "A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [GOC:mah, GOC:ss, PMID:17640523]", "canonical_name": "nBAF complex location"}
{"concept_id": "C2754772", "aliases": [], "types": ["T044"], "canonical_name": "UFM1 activating enzyme activity", "definition": "Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:sp, PMID:20018847]"}
{"concept_id": "C2754773", "aliases": ["UFM1 hydrolase activity"], "types": ["T044"], "canonical_name": "deUFMylase activity", "definition": "A thiol-dependent isopeptidase activity that cleaves UFM1 from a target protein to which it is conjugated. [GOC:sp, PMID:17182609, PMID:20018847]"}
{"concept_id": "C2754774", "aliases": [], "types": ["T044"], "canonical_name": "UFM1 transferase activity", "definition": "Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y --> Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages. [GOC:sp, PMID:20018847]"}
{"concept_id": "C2754775", "aliases": [], "types": ["T044"], "canonical_name": "protein ufmylation", "definition": "Covalent attachment of the ubiquitin-like protein UFM1 to another protein. [GOC:vw, PMID:20018847]"}
{"concept_id": "C2754776", "aliases": [], "types": ["T042"], "canonical_name": "cement gland development", "definition": "The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed. [GOC:bf]"}
{"concept_id": "C2754778", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K56 deacetylation", "definition": "The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone. [GOC:mah]"}
{"concept_id": "C2754779", "aliases": ["Pot1-Tpz1 complex assembly", "shelterin complex formation"], "types": ["T044"], "canonical_name": "Pot1 complex assembly"}
{"concept_id": "C2754780", "aliases": ["protein localisation to medial cortex"], "types": ["T043"], "canonical_name": "protein localization to medial cortex", "definition": "A process in which a protein is transported to, or maintained in, the medial cortex. [GOC:mah]"}
{"concept_id": "C2754781", "aliases": ["integral to external leaflet of plasma membrane", "integral to external side of plasma membrane"], "types": ["T026"], "canonical_name": "integral component of external side of plasma membrane", "definition": "The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C2754782", "aliases": ["zinc ion membrane transport", "zinc transmembrane transport", "zinc II ion transmembrane transport"], "types": ["T044"], "canonical_name": "zinc ion transmembrane transport", "definition": "A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754783", "aliases": ["zinc II ion plasma membrane import", "zinc II ion transmembrane import", "zinc import", "zinc uptake"], "types": ["T044"], "canonical_name": "zinc ion import across plasma membrane", "definition": "The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:vw, PMID:18637840]"}
{"concept_id": "C2754784", "aliases": [], "types": ["T043"], "canonical_name": "regulation of zinc ion transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754785", "aliases": ["regulation of zinc ion membrane transport"], "types": ["T044"], "canonical_name": "regulation of zinc ion transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754787", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of zinc ion transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754788", "aliases": ["negative regulation of zinc ion membrane transport"], "types": ["T043"], "canonical_name": "negative regulation of zinc ion transmembrane transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754790", "aliases": [], "types": ["T046"], "canonical_name": "detoxification of cadmium ion", "definition": "Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion. [GOC:BHF, GOC:kmv, PMID:16741752]"}
{"concept_id": "C2754791", "aliases": [], "types": ["T044"], "definition": "The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis. [GOC:mah]", "canonical_name": "CAAX-box protein processing"}
{"concept_id": "C2754792", "aliases": [], "types": ["T044"], "canonical_name": "CAAX-box protein modification", "definition": "The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins. [GOC:mah]"}
{"concept_id": "C2754793", "aliases": ["hydrogen peroxide mediated signalling pathway", "H2O2 mediated signaling pathway"], "types": ["T044"], "canonical_name": "hydrogen peroxide mediated signaling pathway", "definition": "The series of molecular signals mediated by the detection of hydrogen peroxide (H2O2). [GOC:mah, PMID:17043891]"}
{"concept_id": "C2754794", "aliases": ["pyridine nucleoside anabolism", "pyridine nucleoside biosynthesis", "pyridine nucleoside formation", "pyridine nucleoside synthesis"], "types": ["T044"], "canonical_name": "pyridine nucleoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any pyridine nucleoside, one of a family of organic molecules consisting of a pyridine base covalently bonded to a sugar, usually ribose. [GOC:mah]"}
{"concept_id": "C2754795", "aliases": ["nicotinamide riboside synthesis", "nicotinamide riboside formation", "nicotinamide riboside anabolism", "N-ribosylnicotinamide biosynthetic process", "nicotinamide riboside biosynthesis"], "types": ["T044"], "canonical_name": "nicotinamide riboside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. [GOC:mah, PMID:19846558]"}
{"concept_id": "C2754796", "aliases": ["D-ribosylnicotinic acid metabolic process", "nicotinic acid riboside metabolism"], "types": ["T044"], "canonical_name": "nicotinic acid riboside metabolic process", "definition": "The chemical reactions and pathways involving nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid. [GOC:mah, PMID:19846558]"}
{"concept_id": "C2754797", "aliases": ["D-ribosylnicotinic acid biosynthetic process", "nicotinic acid riboside biosynthesis", "nicotinic acid riboside synthesis", "nicotinic acid riboside formation", "nicotinic acid riboside anabolism"], "types": ["T044"], "canonical_name": "nicotinic acid riboside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid. [GOC:mah, PMID:19846558]"}
{"concept_id": "C2754798", "aliases": [], "types": ["T043"], "canonical_name": "lymphocyte aggregation", "definition": "The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules. [GOC:sl]"}
{"concept_id": "C2754799", "aliases": ["T cell precursor aggregation", "immature T cell aggregation", "immature T-lymphocyte aggregation", "thymic lymphocyte aggregation", "immature T-cell aggregation"], "types": ["T043"], "canonical_name": "thymocyte aggregation", "definition": "The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules. [GOC:sl, PMID:1382990]"}
{"concept_id": "C2754800", "aliases": ["Nem1-Spo7 phosphatase complex location"], "types": ["T026"], "canonical_name": "Nem1-Spo7 phosphatase complex", "definition": "A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p. [GOC:mah, PMID:9822591]"}
{"concept_id": "C2754801", "aliases": ["ubiquitin-dependent protein catabolism via the N-end rule pathway", "ubiquitin-dependent protein breakdown via the N-end rule pathway", "ubiquitin-dependent protein degradation via the N-end rule pathway"], "types": ["T044"], "canonical_name": "ubiquitin-dependent protein catabolic process via the N-end rule pathway", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437]"}
{"concept_id": "C2754802", "aliases": [], "types": ["T026"], "canonical_name": "cellular birth scar", "definition": "Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation. [GOC:mcc, PMID:16672383, PMID:7730409]"}
{"concept_id": "C2754803", "aliases": [], "types": ["T026"], "canonical_name": "neuronal RNA granule"}
{"concept_id": "C2754804", "aliases": [], "types": ["T042"], "canonical_name": "otic vesicle development", "definition": "The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. [GOC:mah]"}
{"concept_id": "C2754805", "aliases": [], "types": ["T042"], "canonical_name": "otic vesicle morphogenesis", "definition": "The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. [GOC:mah]"}
{"concept_id": "C2754806", "aliases": [], "types": ["T026"], "definition": "A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins. [PMID:7758244, PMID:8349728]", "canonical_name": "sphere organelle"}
{"concept_id": "C2754807", "aliases": ["phytosphingosine synthesis", "phytosphingosine biosynthesis", "phytosphingosine formation", "phytosphingosine anabolism"], "types": ["T044"], "canonical_name": "phytosphingosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol. [GOC:mah]"}
{"concept_id": "C2754808", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell-cell adhesion", "definition": "The attachment of an endothelial cell to another endothelial cell via adhesion molecules. [GOC:BHF]"}
{"concept_id": "C2754809", "aliases": ["TGF-B production", "TGFb production", "TGF-beta production", "TGFbeta production", "transforming growth factor-beta production"], "types": ["T040"], "canonical_name": "transforming growth factor beta production", "definition": "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3. [GOC:add, GOC:rv, PMID:16891311, PMID:2022183]"}
{"concept_id": "C2754810", "aliases": ["CCL2 production", "MCP-1 production"], "types": ["T044"], "canonical_name": "monocyte chemotactic protein-1 production", "definition": "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]"}
{"concept_id": "C2754811", "aliases": ["MIP-1b production", "CCL4 production"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 4 production", "definition": "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]"}
{"concept_id": "C2754812", "aliases": ["macrophage inflammatory protein production"], "types": ["T044"], "canonical_name": "macrophage inflammatory protein production"}
{"concept_id": "C2754813", "aliases": ["MIP-1g production", "chemokine (C-C motif) ligand 9 production", "CCL9 production"], "types": ["T044"], "canonical_name": "macrophage inflammatory protein-1 gamma production", "definition": "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]"}
{"concept_id": "C2754814", "aliases": ["MIP-1a production", "CCL3 production", "chemokine (C-C motif) ligand 3 production"], "types": ["T044"], "canonical_name": "macrophage inflammatory protein-1 alpha production", "definition": "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]"}
{"concept_id": "C2754815", "aliases": ["Regulated upon Activation, Normal T-cell Expressed, and Secreted production", "CCL5 production", "RANTES production"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 5 production", "definition": "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]"}
{"concept_id": "C2754816", "aliases": ["TCA-3 production", "T cell activation 3 production", "CCL1 production"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 1 production", "definition": "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]"}
{"concept_id": "C2754817", "aliases": ["CSF3 production", "G-CSF production", "pluripoietin production", "filgrastim production", "lenograstim production", "colony stimulating factor 3 (granulocyte) production", "granulocyte colony stimulating factor production"], "types": ["T044"], "canonical_name": "granulocyte colony-stimulating factor production", "definition": "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]"}
{"concept_id": "C2754818", "aliases": ["CXCL10 production", "chemokine (C-C motif) ligand 10 production"], "types": ["T044"], "canonical_name": "IP-10 production", "definition": "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]"}
{"concept_id": "C2754819", "aliases": [], "types": ["T038"], "canonical_name": "granzyme B production", "definition": "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]"}
{"concept_id": "C2754820", "aliases": ["linoleic acid monooxygenase activity"], "types": ["T044"], "canonical_name": "linoleic acid epoxygenase activity", "definition": "Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid. [GOC:BHF, PMID:11042099]"}
{"concept_id": "C2754822", "aliases": [], "types": ["T044"], "canonical_name": "lysophospholipid acyltransferase activity", "definition": "Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. [GOC:cjk]"}
{"concept_id": "C2754823", "aliases": [], "types": ["T044"], "canonical_name": "lysophosphatidylethanolamine acyltransferase activity", "definition": "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine. [GOC:cjk]"}
{"concept_id": "C2754824", "aliases": [], "types": ["T045"], "canonical_name": "phosphorylation of RNA polymerase II C-terminal domain serine 2 residues", "definition": "The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans. [GOC:krc, PMID:17079683]"}
{"concept_id": "C2754825", "aliases": [], "types": ["T045"], "canonical_name": "phosphorylation of RNA polymerase II C-terminal domain serine 5 residues", "definition": "The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans). [GOC:krc, PMID:17079683]"}
{"concept_id": "C2754826", "aliases": [], "types": ["T043"], "canonical_name": "granulocyte chemotaxis", "definition": "The movement of a granulocyte in response to an external stimulus. [GOC:rph]"}
{"concept_id": "C2754827", "aliases": [], "types": ["T043"], "canonical_name": "regulation of granulocyte chemotaxis", "definition": "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. [GOC:mah]"}
{"concept_id": "C2754828", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of granulocyte chemotaxis", "definition": "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. [GOC:mah]"}
{"concept_id": "C2754829", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of granulocyte chemotaxis", "definition": "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. [GOC:mah]"}
{"concept_id": "C2754830", "aliases": ["vocalisation behaviour"], "types": ["T055"], "canonical_name": "vocalization behavior", "definition": "The behavior in which an organism produces sounds by a mechanism involving its respiratory system. [GOC:mah]"}
{"concept_id": "C2754831", "aliases": ["integral to fungal-type vacuolar membrane"], "types": ["T026"], "canonical_name": "integral component of fungal-type vacuolar membrane", "definition": "The component of the fungal-type vacuole membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C2754832", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of fungal-type vacuolar membrane", "definition": "The component of a fungal-type vacuole membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C2754833", "aliases": ["ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome", "cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown", "cytoplasm-associated proteasomal ubiquitin-dependent protein degradation", "cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism"], "types": ["T044"], "canonical_name": "cytoplasm protein quality control by the ubiquitin-proteasome system", "definition": "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation. [GOC:mah, GOC:rb, PMID:20080635]"}
{"concept_id": "C2754834", "aliases": ["nucleus-associated proteasomal ubiquitin-dependent protein degradation", "ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome", "nucleus-associated proteasomal ubiquitin-dependent protein catabolism", "nucleus-associated proteasomal ubiquitin-dependent protein breakdown"], "types": ["T044"], "canonical_name": "nuclear protein quality control by the ubiquitin-proteasome system", "definition": "The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation. [GOC:mah, GOC:rb, PMID:20080635, PMID:21211726, PMID:21324894]"}
{"concept_id": "C2754835", "aliases": ["mating-type pheromone secretion"], "types": ["T043"], "canonical_name": "mating pheromone secretion", "definition": "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction. [GOC:mah]"}
{"concept_id": "C2754836", "aliases": [], "types": ["T055"], "canonical_name": "optomotor response", "definition": "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish. [GOC:dos, PMID:12726833, PMID:2469195]"}
{"concept_id": "C2754837", "aliases": [], "types": ["T044"], "canonical_name": "dihydroceramidase activity", "definition": "Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine. [GOC:mah, PMID:10900202]"}
{"concept_id": "C2754838", "aliases": ["regulation of TGF-B production", "regulation of TGF-beta production", "regulation of TGFB production", "regulation of TGFbeta production", "regulation of transforming growth factor-beta production"], "types": ["T044"], "canonical_name": "regulation of transforming growth factor beta production", "definition": "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta. [GOC:mah]"}
{"concept_id": "C2754839", "aliases": ["negative regulation of TGF-B production", "negative regulation of transforming growth factor-beta production", "negative regulation of TGFB production", "negative regulation of TGFbeta production", "negative regulation of TGF-beta production"], "types": ["T044"], "canonical_name": "negative regulation of transforming growth factor beta production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta. [GOC:mah]"}
{"concept_id": "C2754840", "aliases": ["positive regulation of TGF-B production", "positive regulation of transforming growth factor-beta production", "positive regulation of TGFB production", "positive regulation of TGF-beta production", "positive regulation of TGFbeta production"], "types": ["T044"], "canonical_name": "positive regulation of transforming growth factor beta production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. [GOC:mah]"}
{"concept_id": "C2754841", "aliases": ["regulation of CCL2 production", "regulation of MCP-1 production"], "types": ["T044"], "canonical_name": "regulation of monocyte chemotactic protein-1 production", "definition": "Any process that modulates the frequency, rate, or extent of production of monocyte chemotactic protein-1. [GOC:mah]"}
{"concept_id": "C2754842", "aliases": ["negative regulation of CCL2 production", "negative regulation of MCP-1 production"], "types": ["T044"], "canonical_name": "negative regulation of monocyte chemotactic protein-1 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1. [GOC:mah]"}
{"concept_id": "C2754843", "aliases": ["positive regulation of CCL2 production", "positive regulation of MCP-1 production"], "types": ["T044"], "canonical_name": "positive regulation of monocyte chemotactic protein-1 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1. [GOC:mah]"}
{"concept_id": "C2754844", "aliases": ["regulation of chemokine (C-C motif) ligand 3 production", "regulation of MIP-1a production", "regulation of CCL3 production"], "types": ["T044"], "canonical_name": "regulation of macrophage inflammatory protein 1 alpha production", "definition": "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha. [GOC:mah]"}
{"concept_id": "C2754845", "aliases": ["regulation of macrophage inflammatory protein production"], "types": ["T044"], "canonical_name": "regulation of macrophage inflammatory protein production"}
{"concept_id": "C2754846", "aliases": ["negative regulation of chemokine (C-C motif) ligand 3 production", "negative regulation of MIP-1a production", "negative regulation of CCL3 production"], "types": ["T044"], "canonical_name": "negative regulation of macrophage inflammatory protein 1 alpha production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha. [GOC:mah]"}
{"concept_id": "C2754847", "aliases": ["negative regulation of macrophage inflammatory protein production"], "types": ["T044"], "canonical_name": "negative regulation of macrophage inflammatory protein production"}
{"concept_id": "C2754848", "aliases": ["positive regulation of MIP-1a production", "positive regulation of CCL3 production", "positive regulation of chemokine (C-C motif) ligand 3 production"], "types": ["T044"], "canonical_name": "positive regulation of macrophage inflammatory protein 1 alpha production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha. [GOC:mah]"}
{"concept_id": "C2754849", "aliases": ["positive regulation of macrophage inflammatory protein production"], "types": ["T044"], "canonical_name": "positive regulation of macrophage inflammatory protein production"}
{"concept_id": "C2754850", "aliases": ["regulation of CCL4 production", "regulation of MIP-1b production"], "types": ["T044"], "canonical_name": "regulation of chemokine (C-C motif) ligand 4 production", "definition": "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4. [GOC:mah]"}
{"concept_id": "C2754851", "aliases": ["negative regulation of CCL4 production", "negative regulation of MIP-1b production"], "types": ["T044"], "canonical_name": "negative regulation of chemokine (C-C motif) ligand 4 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4. [GOC:mah]"}
{"concept_id": "C2754852", "aliases": ["positive regulation of MIP-1b production", "positive regulation of CCL4 production"], "types": ["T044"], "canonical_name": "positive regulation of chemokine (C-C motif) ligand 4 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4. [GOC:mah]"}
{"concept_id": "C2754853", "aliases": ["regulation of chemokine (C-C motif) ligand 9 production", "regulation of CCL9 production", "regulation of MIP-1g production"], "types": ["T044"], "canonical_name": "regulation of macrophage inflammatory protein-1 gamma production", "definition": "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma. [GOC:mah]"}
{"concept_id": "C2754854", "aliases": ["negative regulation of CCL9 production", "negative regulation of chemokine (C-C motif) ligand 9 production", "negative regulation of MIP-1g production"], "types": ["T044"], "canonical_name": "negative regulation of macrophage inflammatory protein-1 gamma production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma. [GOC:mah]"}
{"concept_id": "C2754855", "aliases": ["positive regulation of MIP-1g production", "positive regulation of chemokine (C-C motif) ligand 9 production", "positive regulation of CCL9 production"], "types": ["T044"], "canonical_name": "positive regulation of macrophage inflammatory protein-1 gamma production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma. [GOC:mah]"}
{"concept_id": "C2754856", "aliases": ["regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production", "regulation of RANTES production", "regulation of CCL5 production"], "types": ["T044"], "canonical_name": "regulation of chemokine (C-C motif) ligand 5 production", "definition": "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5. [GOC:mah]"}
{"concept_id": "C2754857", "aliases": ["negative regulation of RANTES production", "negative regulation of CCL5 production", "negative regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production"], "types": ["T044"], "canonical_name": "negative regulation of chemokine (C-C motif) ligand 5 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5. [GOC:mah]"}
{"concept_id": "C2754858", "aliases": ["positive regulation of RANTES production", "positive regulation of CCL5 production", "positive regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production"], "types": ["T044"], "canonical_name": "positive regulation of chemokine (C-C motif) ligand 5 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5. [GOC:mah]"}
{"concept_id": "C2754859", "aliases": ["regulation of TCA-3 production", "regulation of CCL1 production", "regulation of T cell activation 3 production"], "types": ["T044"], "canonical_name": "regulation of chemokine (C-C motif) ligand 1 production", "definition": "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1. [GOC:mah]"}
{"concept_id": "C2754860", "aliases": ["negative regulation of TCA-3 production", "negative regulation of T cell activation 3 production", "negative regulation of CCL1 production"], "types": ["T044"], "canonical_name": "negative regulation of chemokine (C-C motif) ligand 1 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1. [GOC:mah]"}
{"concept_id": "C2754861", "aliases": ["positive regulation of TCA-3 production", "positive regulation of CCL1 production", "positive regulation of T cell activation 3 production"], "types": ["T044"], "canonical_name": "positive regulation of chemokine (C-C motif) ligand 1 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1. [GOC:mah]"}
{"concept_id": "C2754862", "aliases": ["regulation of pluripoietin production", "regulation of lenograstim production", "regulation of G-CSF production", "regulation of CSF3 production", "regulation of colony stimulating factor 3 (granulocyte) production", "regulation of filgrastim production", "regulation of granulocyte colony stimulating factor production"], "types": ["T044"], "canonical_name": "regulation of granulocyte colony-stimulating factor production", "definition": "Any process that modulates the frequency, rate, or extent of production of granulocyte colony-stimulating factor. [GOC:mah]"}
{"concept_id": "C2754863", "aliases": ["negative regulation of granulocyte colony stimulating factor production", "negative regulation of filgrastim production", "negative regulation of CSF3 production", "negative regulation of lenograstim production", "negative regulation of pluripoietin production", "negative regulation of G-CSF production", "negative regulation of colony stimulating factor 3 (granulocyte) production"], "types": ["T044"], "canonical_name": "negative regulation of granulocyte colony-stimulating factor production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor. [GOC:mah]"}
{"concept_id": "C2754864", "aliases": ["positive regulation of granulocyte colony stimulating factor production", "positive regulation of CSF3 production", "positive regulation of colony stimulating factor 3 (granulocyte) production", "positive regulation of filgrastim production", "positive regulation of G-CSF production", "positive regulation of lenograstim production", "positive regulation of pluripoietin production"], "types": ["T044"], "canonical_name": "positive regulation of granulocyte colony-stimulating factor production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony-stimulating factor. [GOC:mah]"}
{"concept_id": "C2754865", "aliases": ["regulation of CXCL10 production", "regulation of chemokine (C-C motif) ligand 10 production"], "types": ["T044"], "canonical_name": "regulation of IP-10 production", "definition": "Any process that modulates the frequency, rate, or extent of production of IP-10. [GOC:mah]"}
{"concept_id": "C2754866", "aliases": ["negative regulation of chemokine (C-C motif) ligand 10 production", "negative regulation of CXCL10 production"], "types": ["T044"], "canonical_name": "negative regulation of IP-10 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of IP-10. [GOC:mah]"}
{"concept_id": "C2754867", "aliases": ["positive regulation of CXCL10 production", "positive regulation of chemokine (C-C motif) ligand 10 production"], "types": ["T044"], "canonical_name": "positive regulation of IP-10 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of IP-10. [GOC:mah]"}
{"concept_id": "C2754868", "aliases": [], "types": ["T044"], "canonical_name": "regulation of granzyme B production", "definition": "Any process that modulates the frequency, rate, or extent of production of granzyme B. [GOC:mah]"}
{"concept_id": "C2754869", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of granzyme B production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granzyme B. [GOC:mah]"}
{"concept_id": "C2754870", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of granzyme B production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of granzyme B. [GOC:mah]"}
{"concept_id": "C2754871", "aliases": ["catenin-TCF7L2 complex location", "catenin-TCF4 complex", "catenin-TCF4 complex location"], "types": ["T026"], "canonical_name": "catenin-TCF7L2 complex", "definition": "A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. [GOC:BHF, GOC:rl, GOC:vk, PMID:14661054]"}
{"concept_id": "C2754872", "aliases": ["gamma-catenin-TCF4 complex location", "plakoglobin-TCF4 complex location", "gamma-catenin-TCF4 complex", "plakoglobin-TCF4 complex", "gamma-catenin-TCF7L2 complex location"], "types": ["T026"], "canonical_name": "gamma-catenin-TCF7L2 complex", "definition": "A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. [GOC:BHF, GOC:vk, PMID:14661054]"}
{"concept_id": "C2754873", "aliases": ["Slit-Robo signaling complex location", "Slit-Robo signalling complex location", "Slit-Robo signalling complex"], "types": ["T026"], "canonical_name": "Slit-Robo signaling complex", "definition": "A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate. [GOC:sart, PMID:17062560, PMID:18359766]"}
{"concept_id": "C2754874", "aliases": ["RNA/DNA hybrid binding"], "types": ["T045"], "canonical_name": "DNA/RNA hybrid binding", "definition": "Binding to a RNA/DNA hybrid. [GOC:ecd]"}
{"concept_id": "C2754875", "aliases": [], "types": ["T043"], "canonical_name": "plant-type cell wall assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall. [GOC:mah]"}
{"concept_id": "C2754876", "aliases": [], "types": ["T043"], "canonical_name": "smooth muscle cell chemotaxis", "definition": "The directed movement of a smooth muscle cell in response to an external stimulus. [GOC:mah]"}
{"concept_id": "C2754877", "aliases": [], "types": ["T043"], "canonical_name": "regulation of smooth muscle cell chemotaxis", "definition": "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis. [GOC:mah]"}
{"concept_id": "C2754878", "aliases": ["down regulation of smooth muscle cell chemotaxis", "down-regulation of smooth muscle cell chemotaxis", "downregulation of smooth muscle cell chemotaxis"], "types": ["T043"], "canonical_name": "negative regulation of smooth muscle cell chemotaxis", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis. [GOC:mah]"}
{"concept_id": "C2754879", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of smooth muscle cell chemotaxis"}
{"concept_id": "C2754880", "aliases": ["up regulation of smooth muscle cell chemotaxis", "up-regulation of smooth muscle cell chemotaxis", "upregulation of smooth muscle cell chemotaxis"], "types": ["T043"], "canonical_name": "positive regulation of smooth muscle cell chemotaxis", "definition": "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis. [GOC:mah]"}
{"concept_id": "C2754881", "aliases": [], "types": ["T043"], "canonical_name": "activation of smooth muscle cell chemotaxis"}
{"concept_id": "C2754882", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of smooth muscle cell chemotaxis"}
{"concept_id": "C2754883", "aliases": [], "types": ["T043"], "canonical_name": "mononuclear cell migration", "definition": "The movement of a mononuclear cell within or between different tissues and organs of the body. [GOC:mah]"}
{"concept_id": "C2754884", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mononuclear cell migration", "definition": "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. [GOC:mah]"}
{"concept_id": "C2754885", "aliases": ["down-regulation of mononuclear cell migration", "downregulation of mononuclear cell migration", "down regulation of mononuclear cell migration"], "types": ["T043"], "canonical_name": "negative regulation of mononuclear cell migration", "definition": "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. [GOC:mah]"}
{"concept_id": "C2754886", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mononuclear cell migration"}
{"concept_id": "C2754887", "aliases": ["upregulation of mononuclear cell migration", "up-regulation of mononuclear cell migration", "up regulation of mononuclear cell migration"], "types": ["T043"], "canonical_name": "positive regulation of mononuclear cell migration", "definition": "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. [GOC:mah]"}
{"concept_id": "C2754888", "aliases": [], "types": ["T043"], "canonical_name": "activation of mononuclear cell migration"}
{"concept_id": "C2754889", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of mononuclear cell migration"}
{"concept_id": "C2754890", "aliases": ["olfactory bulb axon pathfinding"], "types": ["T043"], "canonical_name": "olfactory bulb axon guidance", "definition": "The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754891", "aliases": ["commissural neuron axon pathfinding"], "types": ["T043"], "canonical_name": "commissural neuron axon guidance", "definition": "The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2754892", "aliases": ["response to indole-3-carbinol"], "types": ["T043"], "canonical_name": "response to indole-3-methanol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754893", "aliases": ["cellular response to indole-3-carbinol"], "types": ["T043"], "canonical_name": "cellular response to indole-3-methanol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754894", "aliases": [], "types": ["T026"], "canonical_name": "endocytic vesicle lumen", "definition": "The volume enclosed by the membrane of an endocytic vesicle. [GOC:pde]"}
{"concept_id": "C2754895", "aliases": [], "types": ["T026"], "canonical_name": "sensory dendrite", "definition": "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron. [GOC:dos, GOC:kmv, GOC:mah]"}
{"concept_id": "C2754896", "aliases": [], "types": ["T038"], "canonical_name": "organism emergence from protective structure", "definition": "The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case. [GOC:mah]"}
{"concept_id": "C2754899", "aliases": [], "types": ["T043"], "canonical_name": "striated muscle myosin thick filament assembly", "definition": "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle. [GOC:mah]"}
{"concept_id": "C2754900", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscle myosin thick filament assembly", "definition": "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle. [GOC:mah]"}
{"concept_id": "C2754901", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscle thin filament assembly", "definition": "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle. [GOC:mah]"}
{"concept_id": "C2754902", "aliases": ["protein localization in extracellular region", "protein localisation in extracellular region"], "types": ["T044"], "canonical_name": "protein localization to extracellular region", "definition": "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. [GOC:mah]"}
{"concept_id": "C2754903", "aliases": [], "types": ["T043"], "canonical_name": "protein transport within extracellular region", "definition": "The directed movement of proteins in the extracellular region, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2754904", "aliases": [], "types": ["T044"], "canonical_name": "maintenance of protein location in extracellular region", "definition": "Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere. [GOC:mah]"}
{"concept_id": "C2754905", "aliases": [], "types": ["T042"], "canonical_name": "anatomical structure maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. [GOC:mah]"}
{"concept_id": "C2754906", "aliases": [], "types": ["T042"], "canonical_name": "ectodermal placode development", "definition": "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. [GOC:mah]"}
{"concept_id": "C2754907", "aliases": [], "types": ["T042"], "canonical_name": "ectodermal placode morphogenesis", "definition": "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. [GOC:mah]"}
{"concept_id": "C2754908", "aliases": [], "types": ["T042"], "canonical_name": "olfactory placode development", "definition": "The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. [GOC:mah]"}
{"concept_id": "C2754909", "aliases": [], "types": ["T042"], "canonical_name": "olfactory placode morphogenesis", "definition": "The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. [GOC:mah]"}
{"concept_id": "C2754910", "aliases": [], "types": ["T042"], "canonical_name": "olfactory placode maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory placode to attain its fully functional state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. [GOC:mah]"}
{"concept_id": "C2754911", "aliases": ["regulation of cytoplasmic translocation of MAP kinase", "regulation of MAPK export out of nucleus", "regulation of MAPK export from cell nucleus", "regulation of MAPK transport from nucleus to cytoplasm", "regulation of cytoplasmic translocation of mitogen-activated protein kinase", "regulation of MAPK-nucleus export"], "types": ["T043"], "canonical_name": "regulation of MAPK export from nucleus", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm. [GOC:dgf]"}
{"concept_id": "C2754912", "aliases": [], "types": ["T043"], "canonical_name": "organic substance transport", "definition": "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. [GOC:mah]"}
{"concept_id": "C2754913", "aliases": [], "types": ["T043"], "canonical_name": "detection of organic substance", "definition": "The series of events in which an organic substance stimulus is received by a cell and converted into a molecular signal. [GOC:mah]"}
{"concept_id": "C2754914", "aliases": ["organic molecular entity metabolism", "organic substance metabolism", "organic molecular entity metabolic process"], "types": ["T038"], "canonical_name": "organic substance metabolic process", "definition": "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. [GOC:mah]"}
{"concept_id": "C2754915", "aliases": [], "types": ["T043"], "canonical_name": "nitrogen compound transport", "definition": "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C2754916", "aliases": ["TNFSF cytokine production", "TNF superfamily production"], "types": ["T040"], "canonical_name": "tumor necrosis factor superfamily cytokine production", "definition": "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add]"}
{"concept_id": "C2754917", "aliases": ["membrane macromolecule synthesis", "membrane macromolecule anabolism", "membrane macromolecule formation", "membrane macromolecule biosynthesis"], "types": ["T043"], "canonical_name": "membrane macromolecule biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a membrane in a cell. [GOC:mah]"}
{"concept_id": "C2754918", "aliases": ["basement membrane organisation"], "types": ["T043"], "canonical_name": "basement membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. [GOC:mah]"}
{"concept_id": "C2754919", "aliases": ["ER-associated misfolded protein breakdown", "proteasomal protein catabolism of misfolded ER proteins", "ER-associated misfolded protein degradation", "endoplasmic reticulum-associated misfolded protein catabolism", "ER-associated misfolded protein catabolism", "endoplasmic reticulum-associated misfolded protein catabolic process"], "types": ["T044"], "canonical_name": "ER-associated misfolded protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. [GOC:mah, GOC:vw, PMID:14607247, PMID:19520858]"}
{"concept_id": "C2754920", "aliases": [], "types": ["T044"], "canonical_name": "para-aminobenzoyl-glutamate hydrolase activity", "definition": "Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate. [GOC:imk, PMID:20190044]"}
{"concept_id": "C2754921", "aliases": ["eicosanoid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "icosanoid transmembrane transporter activity", "definition": "Enables the transfer of icosanoids from one side of a membrane to the other. [GOC:sl]"}
{"concept_id": "C2754922", "aliases": ["eicosanoid transport"], "types": ["T043"], "canonical_name": "icosanoid transport", "definition": "The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. [GOC:mah]"}
{"concept_id": "C2754923", "aliases": [], "types": ["T043"], "canonical_name": "leukotriene transport", "definition": "The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups. [GOC:mah]"}
{"concept_id": "C2754924", "aliases": [], "types": ["T043"], "canonical_name": "thromboxane transport", "definition": "The directed movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels. [GOC:mah]"}
{"concept_id": "C2754925", "aliases": ["sodium-independent eicosanoid transport"], "types": ["T043"], "canonical_name": "sodium-independent icosanoid transport", "definition": "The directed, sodium-independent, movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. [GOC:mah, GOC:sl]"}
{"concept_id": "C2754926", "aliases": [], "types": ["T043"], "canonical_name": "sodium-independent leukotriene transport", "definition": "The directed, sodium-independent, movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups. [GOC:mah]"}
{"concept_id": "C2754927", "aliases": [], "types": ["T043"], "canonical_name": "sodium-independent prostaglandin transport", "definition": "The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C2754928", "aliases": [], "types": ["T043"], "canonical_name": "sodium-independent thromboxane transport", "definition": "The directed, sodium-independent, movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels. [GOC:mah]"}
{"concept_id": "C2754929", "aliases": ["detoxification of arsenic"], "types": ["T043"], "canonical_name": "detoxification of arsenic-containing substance", "definition": "Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds. [GOC:kmv, PMID:11313333, PMID:20221439]"}
{"concept_id": "C2754930", "aliases": ["bacterial lipopeptide binding", "bacterial lipoprotein binding"], "types": ["T044"], "canonical_name": "lipopeptide binding", "definition": "Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]"}
{"concept_id": "C2754931", "aliases": ["response to diacylated bacterial lipoprotein"], "types": ["T043"], "canonical_name": "response to diacyl bacterial lipopeptide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]"}
{"concept_id": "C2754932", "aliases": ["response to triacylated bacterial lipoprotein"], "types": ["T044"], "canonical_name": "response to triacyl bacterial lipopeptide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]"}
{"concept_id": "C2754933", "aliases": ["cellular response to diacylated bacterial lipoprotein"], "types": ["T043"], "canonical_name": "cellular response to diacyl bacterial lipopeptide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]"}
{"concept_id": "C2754934", "aliases": ["cellular response to triacylated bacterial lipoprotein"], "types": ["T043"], "canonical_name": "cellular response to triacyl bacterial lipopeptide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]"}
{"concept_id": "C2754935", "aliases": [], "types": ["T042"], "canonical_name": "beak development", "definition": "The progression of the beak over time from its initial formation until its mature state. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus. [GOC:lp, ISBN:0702008729]"}
{"concept_id": "C2754936", "aliases": [], "types": ["T042"], "canonical_name": "beak morphogenesis", "definition": "The process in which the anatomical structures of the beak are generated and organized. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus. [GOC:lp, ISBN:0702008729]"}
{"concept_id": "C2754937", "aliases": [], "types": ["T042"], "canonical_name": "beak formation", "definition": "The process that gives rise to the beak. This process pertains to the initial formation of a structure from unspecified parts. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus. [GOC:lp, ISBN:0702008729]"}
{"concept_id": "C2754938", "aliases": ["response to nitric oxide"], "types": ["T043"], "canonical_name": "cellular response to nitric oxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C2754940", "aliases": ["biotin:apo-pyruvate-carboxylase ligase", "biotin-pyruvate-carboxylase ligase activity", "biotin-[pyruvate carboxylase] ligase activity", "biotin-[pyruvate carboxylase] synthetase activity", "biotin-pyruvate carboxylase synthetase activity"], "types": ["T044"], "canonical_name": "biotin-[pyruvate-carboxylase] ligase activity", "definition": "Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase). [GOC:mah, PMID:10551847]"}
{"concept_id": "C2754941", "aliases": ["IgG immunoglobulin complex"], "types": ["T026"], "definition": "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]", "canonical_name": "IgG immunoglobulin complex location"}
{"concept_id": "C2754942", "aliases": ["IgG immunoglobulin complex location, circulating"], "types": ["T026"], "canonical_name": "IgG immunoglobulin complex, circulating", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754943", "aliases": [], "types": ["T026"], "canonical_name": "IgG antibody"}
{"concept_id": "C2754944", "aliases": [], "types": ["T026"], "canonical_name": "IgG1 antibody"}
{"concept_id": "C2754945", "aliases": [], "types": ["T026"], "canonical_name": "IgG2 antibody"}
{"concept_id": "C2754946", "aliases": [], "types": ["T026"], "canonical_name": "IgG2a antibody"}
{"concept_id": "C2754947", "aliases": [], "types": ["T026"], "canonical_name": "IgG2b antibody"}
{"concept_id": "C2754948", "aliases": [], "types": ["T026"], "canonical_name": "IgG2c antibody"}
{"concept_id": "C2754949", "aliases": [], "types": ["T026"], "canonical_name": "IgG3 antibody"}
{"concept_id": "C2754950", "aliases": [], "types": ["T026"], "canonical_name": "IgG4 antibody"}
{"concept_id": "C2754951", "aliases": ["IgG B cell receptor complex location"], "types": ["T026"], "canonical_name": "IgG B cell receptor complex", "definition": "An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754952", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgG"}
{"concept_id": "C2754953", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgG1"}
{"concept_id": "C2754954", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgG2"}
{"concept_id": "C2754955", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgG2a"}
{"concept_id": "C2754956", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgG2b"}
{"concept_id": "C2754957", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgG2c"}
{"concept_id": "C2754958", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgG3"}
{"concept_id": "C2754959", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgG4"}
{"concept_id": "C2754960", "aliases": [], "types": ["T026"], "canonical_name": "surface IgG"}
{"concept_id": "C2754961", "aliases": [], "types": ["T026"], "canonical_name": "surface IgG1"}
{"concept_id": "C2754962", "aliases": [], "types": ["T026"], "canonical_name": "surface IgG2"}
{"concept_id": "C2754963", "aliases": [], "types": ["T026"], "canonical_name": "surface IgG2a"}
{"concept_id": "C2754964", "aliases": [], "types": ["T026"], "canonical_name": "surface IgG2b"}
{"concept_id": "C2754965", "aliases": [], "types": ["T026"], "canonical_name": "surface IgG2c"}
{"concept_id": "C2754966", "aliases": [], "types": ["T026"], "canonical_name": "surface IgG3"}
{"concept_id": "C2754967", "aliases": [], "types": ["T026"], "canonical_name": "surface IgG4"}
{"concept_id": "C2754968", "aliases": ["IgD immunoglobulin complex location"], "types": ["T026"], "canonical_name": "IgD immunoglobulin complex", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:11282392]"}
{"concept_id": "C2754969", "aliases": ["IgD antibody", "IgD immunoglobulin complex location, circulating"], "types": ["T026"], "canonical_name": "IgD immunoglobulin complex, circulating", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:11282392]"}
{"concept_id": "C2754970", "aliases": ["surface IgD", "membrane-bound IgD", "IgD B cell receptor complex location"], "types": ["T026"], "canonical_name": "IgD B cell receptor complex", "definition": "An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. [GOC:add, ISBN:0781765196, PMID:11282392]"}
{"concept_id": "C2754971", "aliases": ["IgD immunoglobulin complex location, GPI-anchored", "GPI-anchored IgD"], "types": ["T026"], "canonical_name": "IgD immunoglobulin complex, GPI-anchored", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells. [GOC:add, ISBN:0781765196, PMID:11282392]"}
{"concept_id": "C2754972", "aliases": ["IgE immunoglobulin complex location"], "types": ["T026"], "canonical_name": "IgE immunoglobulin complex", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754973", "aliases": ["IgE antibody", "IgE immunoglobulin complex location, circulating"], "types": ["T026"], "canonical_name": "IgE immunoglobulin complex, circulating", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754974", "aliases": ["IgE B cell receptor complex location", "membrane-bound IgE", "surface IgE"], "types": ["T026"], "canonical_name": "IgE B cell receptor complex", "definition": "An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2754975", "aliases": ["IgA immunoglobulin complex location"], "types": ["T026"], "canonical_name": "IgA immunoglobulin complex", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985]"}
{"concept_id": "C2754976", "aliases": ["IgA1 antibody"], "types": ["T026"], "canonical_name": "IgA1 antibody"}
{"concept_id": "C2754977", "aliases": ["IgA2 antibody"], "types": ["T026"], "canonical_name": "IgA2 antibody"}
{"concept_id": "C2754978", "aliases": ["IgA immunoglobulin complex, circulating", "IgA immunoglobulin complex location, circulating"], "types": ["T026"], "definition": "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985]", "canonical_name": "IgA antibody"}
{"concept_id": "C2754979", "aliases": ["IgA B cell receptor complex location"], "types": ["T026"], "canonical_name": "IgA B cell receptor complex", "definition": "An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. [GOC:add, ISBN:0781765196, PMID:16362985]"}
{"concept_id": "C2754980", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgA"}
{"concept_id": "C2754981", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgA1"}
{"concept_id": "C2754982", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgA2"}
{"concept_id": "C2754983", "aliases": [], "types": ["T026"], "canonical_name": "surface IgA"}
{"concept_id": "C2754984", "aliases": [], "types": ["T026"], "canonical_name": "surface IgA1"}
{"concept_id": "C2754985", "aliases": [], "types": ["T026"], "canonical_name": "surface IgA2"}
{"concept_id": "C2754986", "aliases": ["monomeric IgA antibody", "monomeric IgA immunoglobulin complex location"], "types": ["T026"], "canonical_name": "monomeric IgA immunoglobulin complex", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985]"}
{"concept_id": "C2754987", "aliases": [], "types": ["T026"], "canonical_name": "monomeric IgA1 antibody"}
{"concept_id": "C2754988", "aliases": [], "types": ["T026"], "canonical_name": "monomeric IgA2 antibody"}
{"concept_id": "C2754989", "aliases": ["polymeric IgA antibody", "pIgA1 antibody", "pIgA antibody", "polymeric IgA1 antibody", "polymeric IgA immunoglobulin complex location"], "types": ["T026"], "canonical_name": "polymeric IgA immunoglobulin complex", "definition": "A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985]"}
{"concept_id": "C2754990", "aliases": ["dimeric IgA antibody", "dimeric IgA immunoglobulin complex location"], "types": ["T026"], "canonical_name": "dimeric IgA immunoglobulin complex", "definition": "A protein complex composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985]"}
{"concept_id": "C2754991", "aliases": [], "types": ["T026"], "canonical_name": "dimeric IgA1 antibody"}
{"concept_id": "C2754992", "aliases": ["secretory IgA immunoglobulin complex location", "secretory IgA antibody", "sIgA antibody"], "types": ["T026"], "canonical_name": "secretory IgA immunoglobulin complex", "definition": "A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component. [GOC:add, ISBN:0781765196, PMID:16362985]"}
{"concept_id": "C2754993", "aliases": [], "types": ["T026"], "canonical_name": "sIgA1 antibody"}
{"concept_id": "C2754994", "aliases": ["secretory dimeric IgA immunoglobulin complex location", "secretory dimeric IgA antibody"], "types": ["T026"], "canonical_name": "secretory dimeric IgA immunoglobulin complex", "definition": "A dimeric form of secretory IgA immunoglobulin complex. [GOC:add, ISBN:0781765196, PMID:16362985]"}
{"concept_id": "C2754995", "aliases": [], "types": ["T026"], "canonical_name": "secretory dimeric IgA1 antibody"}
{"concept_id": "C2754996", "aliases": ["IgM immunoglobulin complex location"], "types": ["T026"], "canonical_name": "IgM immunoglobulin complex", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:20176268]"}
{"concept_id": "C2754997", "aliases": ["IgM immunoglobulin complex location, circulating", "IgM immunoglobulin complex, circulating"], "types": ["T026"], "definition": "A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:20176268]", "canonical_name": "IgM antibody"}
{"concept_id": "C2754998", "aliases": ["surface IgM", "IgM B cell receptor complex location"], "types": ["T026"], "canonical_name": "IgM B cell receptor complex", "definition": "An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. [GOC:add, ISBN:0781765196, PMID:20176268]"}
{"concept_id": "C2754999", "aliases": [], "types": ["T026"], "canonical_name": "membrane-bound IgM"}
{"concept_id": "C2755000", "aliases": ["pentameric IgM antibody", "pentameric IgM immunoglobulin complex location"], "types": ["T026"], "canonical_name": "pentameric IgM immunoglobulin complex", "definition": "A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide. [GOC:add, ISBN:0781765196, PMID:20176268]"}
{"concept_id": "C2755001", "aliases": ["hexameric IgM immunoglobulin complex location", "hexameric IgM antibody"], "types": ["T026"], "canonical_name": "hexameric IgM immunoglobulin complex", "definition": "A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide. [GOC:add, ISBN:0781765196, PMID:20176268]"}
{"concept_id": "C2755002", "aliases": ["IgW immunoglobulin complex location"], "types": ["T026"], "canonical_name": "IgW immunoglobulin complex", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2755003", "aliases": ["IgX immunoglobulin complex location"], "types": ["T026"], "canonical_name": "IgX immunoglobulin complex", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgX isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgX immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2755004", "aliases": ["IgY immunoglobulin complex location"], "types": ["T026"], "canonical_name": "IgY immunoglobulin complex", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2755005", "aliases": ["IgT immunoglobulin complex location", "IgZ immunoglobulin complex location", "IgZ antibody", "IgT immunoglobulin complex"], "types": ["T026"], "canonical_name": "IgZ immunoglobulin complex", "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish. [GOC:add, ISBN:0781765196]"}
{"concept_id": "C2755006", "aliases": [], "types": ["T026"], "canonical_name": "IgT antibody"}
{"concept_id": "C2755007", "aliases": ["heavy chain immunoglobulin complex", "HCab"], "types": ["T026"], "definition": "A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains. [GOC:add, ISBN:0781765196, PMID:12543123, PMID:16051357]", "canonical_name": "heavy chain immunoglobulin complex location"}
{"concept_id": "C2755008", "aliases": ["Ig NAR immunoglobulin complex location"], "types": ["T026"], "canonical_name": "Ig NAR immunoglobulin complex"}
{"concept_id": "C2755009", "aliases": [], "types": ["T026"], "canonical_name": "IgNAR antibody"}
{"concept_id": "C2755010", "aliases": ["IgNAR immunoglobulin complex location"], "types": ["T026"], "canonical_name": "IgNAR immunoglobulin complex"}
{"concept_id": "C2755011", "aliases": ["nuclear membrane organisation", "nuclear membrane organization and biogenesis"], "types": ["T043"], "canonical_name": "nuclear membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. [GOC:mah]"}
{"concept_id": "C2755012", "aliases": ["nuclear outer membrane organisation", "nuclear outer membrane organization and biogenesis"], "types": ["T043"], "canonical_name": "nuclear outer membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. [GOC:mah]"}
{"concept_id": "C2755013", "aliases": ["nuclear inner membrane organisation", "nuclear inner membrane organization and biogenesis"], "types": ["T043"], "canonical_name": "nuclear inner membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane. [GOC:mah]"}
{"concept_id": "C2755014", "aliases": [], "types": ["T043"], "canonical_name": "Actinobacterium-type cell wall biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Actinobacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. Actinobacterial cell walls contain characteristic mycolic acids, of which some are covalently linked to the cell wall peptidoglycan and others accumulate at the cell surface. [GOC:mah, PMID:15653820, PMID:3149973]"}
{"concept_id": "C2755015", "aliases": ["mycolate metabolic process", "mycolic acid metabolism"], "types": ["T044"], "canonical_name": "mycolic acid metabolic process", "definition": "The chemical reactions and pathways involving mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain. [GOC:mah, PMID:15653820]"}
{"concept_id": "C2755016", "aliases": ["mycolate biosynthetic process", "mycolic acid formation", "mycolic acid anabolism", "mycolic acid biosynthesis", "mycolic acid synthesis"], "types": ["T044"], "canonical_name": "mycolic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain. [GOC:mah, MetaCyc:PWYG-321, PMID:15653820]"}
{"concept_id": "C2755017", "aliases": ["mycolate cell wall layer biogenesis"], "types": ["T043"], "canonical_name": "mycolate cell wall layer assembly", "definition": "The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer. [GOC:mah, MetaCyc:PWY-6397, PMID:15653820, PMID:3149973]"}
{"concept_id": "C2755018", "aliases": ["PDIM cell wall layer assembly", "DIM/DIP cell wall layer biogenesis", "DIM cell wall layer assembly"], "types": ["T043"], "canonical_name": "DIM/DIP cell wall layer assembly", "definition": "The aggregation, arrangement and bonding together of a set of components, including (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate and diphthioceranate, to form the DIM/DIP layer of the Actinobacterium-type cell wall. [GOC:mah, GOC:pr, PMID:15653820, PMID:3149973]"}
{"concept_id": "C2755019", "aliases": [], "types": ["T038"], "canonical_name": "renal system development", "definition": "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]"}
{"concept_id": "C2755020", "aliases": [], "types": ["T038"], "canonical_name": "Malpighian tubule development", "definition": "The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut. [FBbt:00005786, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C2755021", "aliases": ["kidney anlage formation"], "types": ["T042"], "canonical_name": "kidney rudiment formation", "definition": "The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755022", "aliases": ["specification of kidney anlage"], "types": ["T042"], "canonical_name": "kidney field specification", "definition": "The process that results in the delineation of regions of the embryo into the area in which the kidney rudiment will develop. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755023", "aliases": ["maintenance of kidney anlage identity"], "types": ["T038"], "canonical_name": "maintenance of kidney identity", "definition": "The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755024", "aliases": [], "types": ["T042"], "canonical_name": "nephron development", "definition": "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755025", "aliases": [], "types": ["T042"], "canonical_name": "mesangial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755026", "aliases": [], "types": ["T042"], "canonical_name": "glomerular mesangial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755027", "aliases": [], "types": ["T042"], "canonical_name": "nephron epithelium development", "definition": "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755028", "aliases": [], "types": ["T042"], "canonical_name": "glomerular epithelium development", "definition": "The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755029", "aliases": [], "types": ["T042"], "canonical_name": "glomerular endothelium development", "definition": "The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755030", "aliases": ["glomerulus capillary development"], "types": ["T042"], "canonical_name": "glomerulus vasculature development", "definition": "The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755031", "aliases": ["pronephric glomus development"], "types": ["T042"], "canonical_name": "glomus development", "definition": "The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment. [GOC:mtg_kidney_jan10, PMID:10572058, PMID:15647339, PMID:9268568, XAO:0000318]"}
{"concept_id": "C2755032", "aliases": [], "types": ["T042"], "canonical_name": "proximal tubule development", "definition": "The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755033", "aliases": ["glomerular visceral epithelial cell development"], "types": ["T043"], "canonical_name": "podocyte development", "definition": "The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755035", "aliases": ["Bowman's capsule development"], "types": ["T043"], "canonical_name": "glomerular parietal epithelial cell development", "definition": "The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755036", "aliases": [], "types": ["T042"], "canonical_name": "distal tubule development", "definition": "The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755037", "aliases": [], "types": ["T042"], "canonical_name": "proximal convoluted tubule development", "definition": "The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755038", "aliases": ["S3 development"], "types": ["T042"], "canonical_name": "proximal straight tubule development", "definition": "The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755039", "aliases": [], "types": ["T042"], "canonical_name": "ascending thin limb development", "definition": "The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755040", "aliases": [], "types": ["T042"], "canonical_name": "descending thin limb development", "definition": "The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755041", "aliases": ["TAL development"], "types": ["T042"], "canonical_name": "thick ascending limb development", "definition": "The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755042", "aliases": [], "types": ["T042"], "canonical_name": "macula densa development", "definition": "The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755043", "aliases": [], "types": ["T042"], "canonical_name": "distal convoluted tubule development", "definition": "The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is the first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755044", "aliases": ["connecting duct development"], "types": ["T042"], "canonical_name": "connecting tubule development", "definition": "The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755045", "aliases": [], "types": ["T042"], "canonical_name": "nephron morphogenesis", "definition": "The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755046", "aliases": [], "types": ["T042"], "canonical_name": "long nephron development", "definition": "The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755047", "aliases": [], "types": ["T042"], "canonical_name": "short nephron development", "definition": "The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755048", "aliases": ["S1 development"], "types": ["T043"], "canonical_name": "proximal convoluted tubule segment 1 development", "definition": "The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes. [GOC:mtg_kidney_jan10, MA:0002612]"}
{"concept_id": "C2755049", "aliases": ["S2 development"], "types": ["T042"], "canonical_name": "proximal convoluted tubule segment 2 development", "definition": "The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride. [GOC:mtg_kidney_jan10, MA:0002613]"}
{"concept_id": "C2755050", "aliases": ["nephron epithelium formation"], "types": ["T042"], "definition": "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. [GOC:mtg_kidney_jan10]", "canonical_name": "renal vesicle formation"}
{"concept_id": "C2755051", "aliases": ["nephron induction", "positive regulation of nephron formation"], "types": ["T043"], "canonical_name": "renal vesicle induction", "definition": "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755052", "aliases": ["pre-tubular aggregate formation", "mesenchymal cell condensation involved in renal vesicle formation"], "types": ["T043"], "definition": "The cell adhesion process in which mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney. [GOC:mtg_kidney_jan10]", "canonical_name": "nephron epithelium formation"}
{"concept_id": "C2755053", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal to epithelial transition involved in renal vesicle formation", "definition": "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755054", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal stem cell differentiation involved in nephron morphogenesis", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755055", "aliases": [], "types": ["T040"], "canonical_name": "mesenchymal stem cell maintenance involved in nephron morphogenesis", "definition": "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755056", "aliases": ["regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis", "regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis"], "types": ["T038"], "canonical_name": "regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis", "definition": "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755057", "aliases": ["negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis", "negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis"], "types": ["T038"], "canonical_name": "negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis", "definition": "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755058", "aliases": ["positive regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis", "positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis"], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis", "definition": "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755059", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation and contributes to the shaping of a nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755060", "aliases": ["regulation of pre-tubular aggregate formation by cell-cell signalling"], "types": ["T043"], "canonical_name": "regulation of pre-tubular aggregate formation by cell-cell signaling", "definition": "Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process in which mesenchymal cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755061", "aliases": [], "types": ["T042"], "canonical_name": "collecting duct development", "definition": "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755062", "aliases": [], "types": ["T042"], "canonical_name": "convergent extension involved in nephron morphogenesis", "definition": "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755063", "aliases": ["establishment of planar cell polarity involved in nephron morphogenesis"], "types": ["T042"], "canonical_name": "establishment of planar polarity involved in nephron morphogenesis", "definition": "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755064", "aliases": ["proximal-distal pattern formation involved in nephron development", "proximal/distal nephron patterning"], "types": ["T042"], "canonical_name": "proximal/distal pattern formation involved in nephron development", "definition": "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end). [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755065", "aliases": ["renal system pattern formation"], "types": ["T042"], "canonical_name": "renal system pattern specification", "definition": "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755066", "aliases": [], "types": ["T042"], "canonical_name": "comma-shaped body morphogenesis", "definition": "The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755067", "aliases": [], "types": ["T042"], "canonical_name": "S-shaped body morphogenesis", "definition": "The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755068", "aliases": [], "types": ["T042"], "canonical_name": "juxtaglomerular apparatus development", "definition": "The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755069", "aliases": [], "types": ["T043"], "canonical_name": "juxtaglomerulus cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755070", "aliases": ["inner renal medulla development"], "types": ["T042"], "canonical_name": "renal inner medulla development", "definition": "The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755071", "aliases": ["outer renal medulla development"], "types": ["T042"], "canonical_name": "renal outer medulla development", "definition": "The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755072", "aliases": [], "types": ["T042"], "canonical_name": "renal cortex development", "definition": "The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755073", "aliases": ["pyramids development", "renal medulla development", "renal pyramid development", "kidney pyramid development"], "types": ["T042"], "canonical_name": "pyramid development", "definition": "The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755074", "aliases": [], "types": ["T042"], "canonical_name": "inner stripe development", "definition": "The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755075", "aliases": [], "types": ["T042"], "canonical_name": "outer stripe development", "definition": "The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755076", "aliases": [], "types": ["T042"], "canonical_name": "cortical collecting duct development", "definition": "The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755077", "aliases": [], "types": ["T042"], "canonical_name": "outer medullary collecting duct development", "definition": "The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755078", "aliases": [], "types": ["T042"], "canonical_name": "inner medullary collecting duct development", "definition": "The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755079", "aliases": ["S1 cell differentiation"], "types": ["T043"], "canonical_name": "proximal convoluted tubule segment 1 cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the S1 cells of the kidney as it progresses from its formation to the mature state. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755080", "aliases": [], "types": ["T042"], "canonical_name": "short descending thin limb development", "definition": "The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755081", "aliases": [], "types": ["T042"], "canonical_name": "long descending thin limb development", "definition": "The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755082", "aliases": [], "types": ["T042"], "canonical_name": "long descending thin limb bend development", "definition": "The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755083", "aliases": [], "types": ["T042"], "canonical_name": "prebend segment development", "definition": "The process whose specific outcome is the progression of the prebend segment over time, from its formation to the mature structure. The prebend segment is a part of the descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755084", "aliases": [], "types": ["T042"], "canonical_name": "early distal convoluted tubule development", "definition": "The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755085", "aliases": [], "types": ["T042"], "canonical_name": "late distal convoluted tubule development", "definition": "The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755086", "aliases": ["distal convoluted tubule cell differentiation"], "types": ["T043"], "canonical_name": "DCT cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755087", "aliases": ["intermediate tubule development"], "types": ["T042"], "canonical_name": "loop of Henle development", "definition": "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755088", "aliases": ["kidney interstitial cell differentiation"], "types": ["T043"], "canonical_name": "kidney interstitial fibroblast differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755089", "aliases": [], "types": ["T042"], "canonical_name": "kidney stroma development", "definition": "The process whose specific outcome is the progression of the kidney stroma over time, from its formation to the mature structure. The kidney stroma is the mesenchyme of the mature kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755090", "aliases": [], "types": ["T042"], "canonical_name": "kidney epithelium development", "definition": "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755091", "aliases": [], "types": ["T042"], "canonical_name": "kidney mesenchyme development", "definition": "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755092", "aliases": [], "types": ["T042"], "canonical_name": "metanephric mesenchyme development", "definition": "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755093", "aliases": [], "types": ["T042"], "canonical_name": "nephrogenic mesenchyme development", "definition": "The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755094", "aliases": [], "types": ["T042"], "canonical_name": "renal vesicle morphogenesis", "definition": "The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755095", "aliases": [], "types": ["T042"], "canonical_name": "nephron tubule morphogenesis", "definition": "The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755096", "aliases": [], "types": ["T042"], "canonical_name": "nephron tubule formation", "definition": "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755097", "aliases": [], "types": ["T042"], "canonical_name": "nephron tubule development", "definition": "The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755098", "aliases": [], "types": ["T042"], "canonical_name": "specification of nephron tubule identity", "definition": "The process in which the tubules arranged along the proximal/distal axis of the nephron acquire their identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755099", "aliases": [], "types": ["T042"], "canonical_name": "specification of proximal tubule identity", "definition": "The process in which the proximal tubule of the kidney nephron acquires its identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755100", "aliases": [], "types": ["T042"], "canonical_name": "specification of distal tubule identity", "definition": "The process in which the distal tubule of the kidney nephron acquires its identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755101", "aliases": [], "types": ["T042"], "canonical_name": "specification of connecting tubule identity", "definition": "The process in which the connecting tubule of the kidney nephron acquires its identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755102", "aliases": ["specification of intermediate tubule identity"], "types": ["T042"], "canonical_name": "specification of loop of Henle identity", "definition": "The process in which the loop of Henle of the kidney nephron acquires its identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755103", "aliases": [], "types": ["T042"], "canonical_name": "renal vesicle development", "definition": "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755104", "aliases": [], "types": ["T042"], "canonical_name": "nephron epithelium morphogenesis", "definition": "The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755105", "aliases": [], "types": ["T043"], "canonical_name": "stem cell proliferation", "definition": "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755106", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal stem cell proliferation involved in nephron morphogenesis", "definition": "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755107", "aliases": [], "types": ["T043"], "canonical_name": "regulation of stem cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755108", "aliases": [], "types": ["T042"], "canonical_name": "ureteric bud invasion", "definition": "The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755109", "aliases": ["metanephros formation"], "types": ["T042"], "canonical_name": "metanephric renal vesicle formation", "definition": "The developmental process pertaining to the initial formation of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755110", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of metanephros formation"}
{"concept_id": "C2755111", "aliases": [], "types": ["T040"], "canonical_name": "regulation of branch elongation involved in ureteric bud branching", "definition": "Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755112", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of branch elongation involved in ureteric bud branching", "definition": "Any process that reduces the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755113", "aliases": ["negative regulation of branch elongation involved in ureteric bud branching by BMP signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway", "definition": "The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the reduction of the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755114", "aliases": ["kidney anterior/posterior pattern specification", "anterior/posterior pattern formation involved in kidney development", "kidney anterior/posterior pattern formation"], "types": ["T042"], "canonical_name": "anterior/posterior pattern specification involved in kidney development", "definition": "The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755115", "aliases": [], "types": ["T042"], "canonical_name": "ureteric bud anterior/posterior pattern formation"}
{"concept_id": "C2755116", "aliases": ["specification of ureteric bud anterior/posterior asymmetry"], "types": ["T042"], "canonical_name": "specification of ureteric bud anterior/posterior symmetry", "definition": "The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755117", "aliases": ["specification of ureteric bud anterior/posterior symmetry by BMP signalling pathway", "specification of ureteric bud anterior/posterior asymmetry by BMP signaling pathway"], "types": ["T044"], "canonical_name": "specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway", "definition": "The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755118", "aliases": [], "types": ["T042"], "canonical_name": "glomerulus morphogenesis", "definition": "The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755119", "aliases": [], "types": ["T042"], "canonical_name": "glomerulus vasculature morphogenesis", "definition": "The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755120", "aliases": [], "types": ["T042"], "canonical_name": "glomerular capillary formation", "definition": "The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755121", "aliases": [], "types": ["T042"], "canonical_name": "ureteric peristalsis", "definition": "A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755122", "aliases": [], "types": ["T038"], "canonical_name": "regulation of ureteric bud formation", "definition": "Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755123", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of ureteric bud formation", "definition": "Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755124", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "definition": "Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755125", "aliases": [], "types": ["T042"], "canonical_name": "glomerular mesangium development", "definition": "The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755126", "aliases": [], "types": ["T043"], "canonical_name": "glomerular mesangial cell proliferation", "definition": "The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755127", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in kidney development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755128", "aliases": ["glomerular visceral epithelial cell differentiation"], "types": ["T043"], "canonical_name": "podocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755129", "aliases": [], "types": ["T042"], "canonical_name": "head kidney development", "definition": "The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis. [GOC:mtg_kidney_jan10, ZFA:0000669]"}
{"concept_id": "C2755130", "aliases": ["pronephric kidney morphogenesis"], "types": ["T042"], "canonical_name": "pronephros morphogenesis", "definition": "The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755131", "aliases": [], "types": ["T042"], "canonical_name": "head kidney morphogenesis", "definition": "The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. [GOC:mtg_kidney_jan10, ZFA:0000669]"}
{"concept_id": "C2755132", "aliases": ["pronephric kidney formation"], "types": ["T042"], "canonical_name": "pronephros formation", "definition": "The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755133", "aliases": [], "types": ["T042"], "canonical_name": "head kidney formation", "definition": "The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. [GOC:mtg_kidney_jan10, ZFA:0000669]"}
{"concept_id": "C2755134", "aliases": ["pronephric kidney structural organization", "pronephros structural organisation"], "types": ["T042"], "canonical_name": "pronephros structural organization", "definition": "The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755135", "aliases": ["head kidney structural organisation"], "types": ["T042"], "canonical_name": "head kidney structural organization", "definition": "The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. [GOC:mtg_kidney_jan10, ZFA:0000669]"}
{"concept_id": "C2755136", "aliases": ["pronephric kidney maturation"], "types": ["T042"], "canonical_name": "pronephros maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755137", "aliases": [], "types": ["T042"], "canonical_name": "head kidney maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. [GOC:mtg_kidney_jan10, ZFA:0000669]"}
{"concept_id": "C2755138", "aliases": ["Goormaghtigh proliferation", "lacis cell proliferation"], "types": ["T043"], "canonical_name": "extraglomerular mesangial cell proliferation", "definition": "The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755139", "aliases": [], "types": ["T043"], "canonical_name": "intraglomerular mesangial cell proliferation", "definition": "The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755140", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glomerular mesangial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755141", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glomerular mesangial cell proliferation", "definition": "Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755142", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glomerular mesangial cell proliferation", "definition": "Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755143", "aliases": [], "types": ["T042"], "canonical_name": "renal capsule development", "definition": "The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755144", "aliases": [], "types": ["T042"], "canonical_name": "renal capsule morphogenesis", "definition": "The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755145", "aliases": [], "types": ["T042"], "canonical_name": "renal capsule formation", "definition": "The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755146", "aliases": [], "types": ["T042"], "canonical_name": "renal capsule specification", "definition": "The regionalization process in which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755147", "aliases": [], "types": ["T042"], "canonical_name": "kidney mesenchyme morphogenesis", "definition": "The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755148", "aliases": [], "types": ["T042"], "canonical_name": "mesenchyme morphogenesis", "definition": "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755149", "aliases": [], "types": ["T042"], "canonical_name": "metanephric mesenchyme morphogenesis", "definition": "The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755150", "aliases": [], "types": ["T042"], "canonical_name": "nephrogenic mesenchyme morphogenesis", "definition": "The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755151", "aliases": [], "types": ["T043"], "canonical_name": "kidney mesenchymal cell proliferation", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755152", "aliases": [], "types": ["T043"], "canonical_name": "metanephric mesenchymal cell proliferation involved in metanephros development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755153", "aliases": [], "types": ["T043"], "canonical_name": "condensed mesenchymal cell proliferation", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755154", "aliases": ["ureteric bud mesenchymal cell proliferation"], "types": ["T043"], "canonical_name": "mesenchymal cell proliferation involved in ureteric bud development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755155", "aliases": [], "types": ["T043"], "canonical_name": "glomerular parietal epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755156", "aliases": ["distal convoluted tubule cell development"], "types": ["T043"], "canonical_name": "DCT cell development", "definition": "The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755157", "aliases": ["kidney interstitial cell development"], "types": ["T043"], "canonical_name": "renal interstitial fibroblast development", "definition": "The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755158", "aliases": [], "types": ["T043"], "canonical_name": "juxtaglomerulus cell development", "definition": "The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755159", "aliases": [], "types": ["T043"], "canonical_name": "mesangial cell development", "definition": "The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755160", "aliases": [], "types": ["T043"], "canonical_name": "glomerular mesangial cell development", "definition": "The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755161", "aliases": ["S1 cell development"], "types": ["T043"], "canonical_name": "proximal convoluted tubule segment 1 cell development", "definition": "The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755162", "aliases": ["distal convoluted tubule cell fate commitment"], "types": ["T043"], "canonical_name": "DCT cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755163", "aliases": ["Bowman's capsule cell fate commitment"], "types": ["T043"], "canonical_name": "glomerular parietal epithelial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755164", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755165", "aliases": ["glomerular visceral epithelial cell fate commitment"], "types": ["T043"], "canonical_name": "podocyte cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755166", "aliases": [], "types": ["T043"], "canonical_name": "juxtaglomerulus cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755167", "aliases": [], "types": ["T043"], "canonical_name": "mesangial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755168", "aliases": [], "types": ["T043"], "canonical_name": "glomerular mesangial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755169", "aliases": ["kidney interstitial cell fate commitment"], "types": ["T043"], "canonical_name": "renal interstitial fibroblast fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a renal fibroblast. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755170", "aliases": ["S1 cell fate commitment"], "types": ["T043"], "canonical_name": "proximal convoluted tubule segment 1 cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755171", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration involved in nephron tubule morphogenesis", "definition": "The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755172", "aliases": [], "types": ["T042"], "canonical_name": "distal tubule morphogenesis", "definition": "The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755173", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration involved in distal tubule morphogenesis", "definition": "The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755174", "aliases": [], "types": ["T042"], "canonical_name": "proximal tubule morphogenesis", "definition": "The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755175", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration involved in proximal tubule morphogenesis", "definition": "The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755176", "aliases": [], "types": ["T043"], "canonical_name": "nephron tubule epithelial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755177", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell differentiation involved in kidney development", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755178", "aliases": [], "types": ["T043"], "canonical_name": "metanephric mesenchymal cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755179", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric epithelium development", "definition": "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755180", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric tubule development", "definition": "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755181", "aliases": [], "types": ["T042"], "canonical_name": "anterior mesonephric tubule development", "definition": "The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755182", "aliases": [], "types": ["T042"], "canonical_name": "posterior mesonephric tubule development", "definition": "The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755183", "aliases": [], "types": ["T042"], "canonical_name": "specification of mesonephric tubule identity", "definition": "The process in which the tubules of the mesonephros acquire their identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755184", "aliases": [], "types": ["T042"], "canonical_name": "specification of anterior mesonephric tubule identity", "definition": "The process in which the tubules of the anterior mesonephros acquire their identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755185", "aliases": [], "types": ["T042"], "canonical_name": "specification of posterior mesonephric tubule identity", "definition": "The process in which the tubules of the posterior mesonephros acquire their identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755186", "aliases": [], "types": ["T042"], "canonical_name": "metanephric tubule development", "definition": "The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755187", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric tubule morphogenesis", "definition": "The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755188", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric tubule formation", "definition": "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755189", "aliases": [], "types": ["T042"], "canonical_name": "metanephric tubule morphogenesis", "definition": "The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755190", "aliases": [], "types": ["T042"], "canonical_name": "metanephric tubule formation", "definition": "The developmental process pertaining to the initial formation of a metanephric tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755191", "aliases": [], "types": ["T042"], "canonical_name": "epithelial tube formation", "definition": "The developmental process pertaining to the initial formation of an epithelial tube. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755192", "aliases": [], "types": ["T042"], "canonical_name": "nephric duct development", "definition": "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755193", "aliases": ["Wolffian duct development"], "types": ["T042"], "canonical_name": "mesonephric duct development", "definition": "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755194", "aliases": [], "types": ["T042"], "canonical_name": "nephric duct morphogenesis", "definition": "The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755195", "aliases": [], "types": ["T042"], "canonical_name": "nephric duct formation", "definition": "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755196", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric duct morphogenesis", "definition": "The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755197", "aliases": ["Wolffian duct formation"], "types": ["T042"], "canonical_name": "mesonephric duct formation", "definition": "The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755198", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nephron tubule epithelial cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755199", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of nephron tubule epithelial cell differentiation", "definition": "Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755200", "aliases": [], "types": ["T043"], "canonical_name": "renal vesicle progenitor cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755201", "aliases": [], "types": ["T042"], "canonical_name": "metanephric cap development", "definition": "The biological process whose specific outcome is the progression of the metanephric cap from an initial condition to its mature state. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755202", "aliases": [], "types": ["T042"], "canonical_name": "metanephric cap morphogenesis", "definition": "The process in which the anatomical structures of the metanephric cap are generated and organized. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755203", "aliases": [], "types": ["T042"], "canonical_name": "metanephric cap formation", "definition": "The developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755204", "aliases": [], "types": ["T042"], "canonical_name": "metanephric cap specification", "definition": "The process in which the metanephric cap acquires its identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755205", "aliases": [], "types": ["T042"], "canonical_name": "ureter development", "definition": "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755206", "aliases": ["ureter epithelium development"], "types": ["T042"], "canonical_name": "ureter urothelium development", "definition": "The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755207", "aliases": [], "types": ["T042"], "canonical_name": "ureter smooth muscle development", "definition": "The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755208", "aliases": [], "types": ["T043"], "canonical_name": "ureter epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755209", "aliases": [], "types": ["T043"], "canonical_name": "ureter smooth muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755210", "aliases": [], "types": ["T042"], "canonical_name": "kidney smooth muscle tissue development", "definition": "The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755211", "aliases": [], "types": ["T043"], "canonical_name": "kidney smooth muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755212", "aliases": ["pronephros proximal/distal pattern formation"], "types": ["T042"], "canonical_name": "proximal/distal pattern formation involved in pronephric nephron development", "definition": "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755213", "aliases": [], "types": ["T042"], "canonical_name": "ureter morphogenesis", "definition": "The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755214", "aliases": ["ureter mesenchymal cell proliferation", "ureteral mesenchymal cell proliferation"], "types": ["T043"], "canonical_name": "mesenchymal cell proliferation involved in ureter development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755215", "aliases": ["regulation of ureter mesenchymal cell proliferation", "regulation of ureteral mesenchymal cell proliferation"], "types": ["T043"], "canonical_name": "regulation of mesenchymal cell proliferation involved in ureter development", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755216", "aliases": ["negative regulation of ureteral mesenchymal cell proliferation", "negative regulation of ureter mesenchymal cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of mesenchymal cell proliferation involved in ureter development", "definition": "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755217", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mesenchymal cell proliferation", "definition": "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755218", "aliases": [], "types": ["T043"], "canonical_name": "cell differentiation involved in metanephros development", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. [GOC:mah, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755219", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in metanephros development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755220", "aliases": ["cell-cell signalling involved in metanephros development"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in metanephros development", "definition": "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755221", "aliases": [], "types": ["T042"], "canonical_name": "metanephric collecting duct development", "definition": "The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755222", "aliases": [], "types": ["T042"], "canonical_name": "metanephric juxtaglomerular apparatus development", "definition": "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755223", "aliases": [], "types": ["T042"], "canonical_name": "metanephric epithelium development", "definition": "The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755224", "aliases": [], "types": ["T042"], "canonical_name": "metanephric smooth muscle tissue development", "definition": "The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755225", "aliases": [], "types": ["T043"], "canonical_name": "metanephric mesangial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the metanephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755226", "aliases": [], "types": ["T042"], "canonical_name": "metanephric nephron development", "definition": "The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755227", "aliases": ["metanephric pyramid development", "metanephric renal medulla development", "metanephric kidney pyramid development", "metanephric renal pyramid development"], "types": ["T042"], "canonical_name": "metanephric pyramids development", "definition": "The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755229", "aliases": [], "types": ["T042"], "canonical_name": "metanephric capsule development", "definition": "The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755230", "aliases": [], "types": ["T042"], "canonical_name": "metanephric cortex development", "definition": "The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755231", "aliases": [], "types": ["T042"], "canonical_name": "regulation of metanephros development", "definition": "Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755232", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of metanephros development", "definition": "Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755233", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of metanephros development", "definition": "Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755234", "aliases": [], "types": ["T042"], "canonical_name": "metanephric ascending thin limb development", "definition": "The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755235", "aliases": [], "types": ["T042"], "canonical_name": "metanephric cortical collecting duct development", "definition": "The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755236", "aliases": [], "types": ["T042"], "canonical_name": "metanephric descending thin limb development", "definition": "The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755237", "aliases": [], "types": ["T042"], "canonical_name": "metanephric distal convoluted tubule development", "definition": "The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755238", "aliases": [], "types": ["T042"], "canonical_name": "metanephric early distal convoluted tubule development", "definition": "The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755239", "aliases": [], "types": ["T042"], "canonical_name": "metanephric glomerular mesangium development", "definition": "The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755240", "aliases": ["metanephric glomerular development"], "types": ["T042"], "canonical_name": "metanephric glomerulus development", "definition": "The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros. [GOC:mah]"}
{"concept_id": "C2755241", "aliases": [], "types": ["T042"], "canonical_name": "metanephric late distal convoluted tubule development", "definition": "The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755242", "aliases": [], "types": ["T042"], "canonical_name": "metanephric long descending thin limb bend development", "definition": "The process whose specific outcome is the progression of the metanephric long descending thin limb bend over time, from its formation to the mature structure. The metanephric long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755243", "aliases": [], "types": ["T042"], "canonical_name": "metanephric macula densa development", "definition": "The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755244", "aliases": [], "types": ["T042"], "canonical_name": "metanephric prebend segment development", "definition": "The process whose specific outcome is the progression of the metanephric prebend segment over time, from its formation to the mature structure. The metanephric prebend segment is a part of the metanephric descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755245", "aliases": [], "types": ["T042"], "canonical_name": "metanephric proximal convoluted tubule development", "definition": "The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755246", "aliases": ["metanephric S3 development"], "types": ["T042"], "canonical_name": "metanephric proximal straight tubule development", "definition": "The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755247", "aliases": ["metanephric S1 development"], "types": ["T042"], "canonical_name": "metanephric proximal convoluted tubule segment 1 development", "definition": "The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755248", "aliases": ["metanephric S2 development"], "types": ["T042"], "canonical_name": "metanephric proximal convoluted tubule segment 2 development", "definition": "The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755249", "aliases": ["metanephric TAL development"], "types": ["T042"], "canonical_name": "metanephric thick ascending limb development", "definition": "The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755250", "aliases": [], "types": ["T042"], "canonical_name": "metanephric nephron tubule development", "definition": "The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755251", "aliases": [], "types": ["T042"], "canonical_name": "metanephric distal tubule development", "definition": "The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755252", "aliases": ["metanephric intermediate tubule development"], "types": ["T042"], "canonical_name": "metanephric loop of Henle development", "definition": "The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755253", "aliases": [], "types": ["T042"], "canonical_name": "metanephric proximal tubule development", "definition": "The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755254", "aliases": ["juxtamedullary nephron development"], "types": ["T042"], "canonical_name": "metanephric long nephron development", "definition": "The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755255", "aliases": ["metanephric distal convoluted tubule cell differentiation"], "types": ["T043"], "canonical_name": "metanephric DCT cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755256", "aliases": ["metanephric distal convoluted tubule cell development"], "types": ["T043"], "canonical_name": "metanephric DCT cell development", "definition": "The process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755257", "aliases": ["metanephric distal convoluted tubule cell fate commitment"], "types": ["T043"], "canonical_name": "metanephric DCT cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755258", "aliases": [], "types": ["T042"], "canonical_name": "metanephric nephron epithelium development", "definition": "The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755259", "aliases": [], "types": ["T042"], "canonical_name": "metanephric glomerular epithelium development", "definition": "The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755260", "aliases": [], "types": ["T043"], "canonical_name": "metanephric glomerular parietal epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755261", "aliases": ["metanephric Bowman's capsule development"], "types": ["T043"], "canonical_name": "metanephric glomerular parietal epithelial cell development", "definition": "The process whose specific outcome is the progression of a metanephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755262", "aliases": ["metanephric Bowman's capsule cell fate commitment"], "types": ["T043"], "canonical_name": "metanephric glomerular parietal epithelial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755263", "aliases": ["metanephric glomerular visceral epithelial cell differentiation"], "types": ["T043"], "canonical_name": "metanephric podocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755264", "aliases": ["metanephric glomerular visceral epithelial cell development"], "types": ["T043"], "canonical_name": "metanephric podocyte development", "definition": "The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755265", "aliases": ["metanephric glomerular visceral epithelial cell fate commitment"], "types": ["T043"], "canonical_name": "metanephric podocyte cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755266", "aliases": [], "types": ["T043"], "canonical_name": "metanephric juxtaglomerulus cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the metanephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755267", "aliases": [], "types": ["T043"], "canonical_name": "metanephric juxtaglomerulus cell development", "definition": "The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755268", "aliases": [], "types": ["T043"], "canonical_name": "metanephric juxtaglomerulus cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric juxtaglomerulus cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755269", "aliases": [], "types": ["T043"], "canonical_name": "metanephric glomerular mesangial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755270", "aliases": [], "types": ["T043"], "canonical_name": "metanephric glomerular mesangial cell development", "definition": "The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755271", "aliases": [], "types": ["T043"], "canonical_name": "metanephric glomerular mesangial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular mesangial cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755272", "aliases": [], "types": ["T043"], "canonical_name": "metanephric nephron tubule epithelial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755273", "aliases": ["metanephros interstitial cell differentiation"], "types": ["T043"], "canonical_name": "metanephric interstitial fibroblast differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the metanephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755274", "aliases": ["metanephros interstitial cell development"], "types": ["T043"], "canonical_name": "metanephric interstitial fibroblast development", "definition": "The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755275", "aliases": ["metanephros interstitial cell fate commitment"], "types": ["T043"], "canonical_name": "metanephric interstitial fibroblast fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial fibroblast. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755276", "aliases": ["metanephric lacis cell proliferation"], "types": ["T043"], "canonical_name": "metanephric Goormaghtigh proliferation"}
{"concept_id": "C2755277", "aliases": [], "types": ["T043"], "canonical_name": "metanephric glomerular mesangial cell proliferation involved in metanephros development", "definition": "The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755278", "aliases": [], "types": ["T043"], "canonical_name": "metanephric intraglomerular mesangial cell proliferation", "definition": "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755279", "aliases": [], "types": ["T042"], "canonical_name": "metanephric glomerular endothelium development", "definition": "The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755280", "aliases": [], "types": ["T042"], "canonical_name": "metanephric capsule morphogenesis", "definition": "The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755281", "aliases": [], "types": ["T042"], "canonical_name": "metanephric capsule formation", "definition": "The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755282", "aliases": [], "types": ["T042"], "canonical_name": "metanephric capsule specification", "definition": "The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755283", "aliases": ["metanephros pattern specification", "metanephros pattern formation", "pattern formation involved in metanephros development"], "types": ["T042"], "canonical_name": "pattern specification involved in metanephros development", "definition": "Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755284", "aliases": [], "types": ["T042"], "canonical_name": "metanephric long descending thin limb development", "definition": "The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755285", "aliases": [], "types": ["T042"], "canonical_name": "metanephric short nephron development", "definition": "The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755286", "aliases": [], "types": ["T042"], "canonical_name": "metanephric short descending thin limb development", "definition": "The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755287", "aliases": ["proximal/distal metanephric nephron patterning", "proximal-distal pattern formation involved in metanephric nephron development"], "types": ["T042"], "canonical_name": "proximal/distal pattern formation involved in metanephric nephron development", "definition": "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end). [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755288", "aliases": [], "types": ["T042"], "canonical_name": "metanephric nephron morphogenesis", "definition": "The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2755289", "aliases": ["positive regulation of cytokinin mediated signaling pathway", "positive regulation of cytokinin mediated signalling"], "types": ["T044"], "canonical_name": "positive regulation of cytokinin-activated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of cytokinin signaling. [GOC:dhl]"}
{"concept_id": "C2755290", "aliases": ["GDP-L-galactose phosphorylase activity"], "types": ["T044"], "canonical_name": "GDP-L-galactose phosphorylase activity", "definition": "Catalysis of the reaction: GDP-L-galactose + phosphate = L-galactose-1-P + GDP. [EC:2.7.7.69, PMID:18463094]"}
{"concept_id": "C2755291", "aliases": [], "types": ["T044"], "canonical_name": "GDP-D-glucose phosphorylase activity", "definition": "Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP. [PMID:18463094]"}
{"concept_id": "C2755292", "aliases": [], "types": ["T044"], "canonical_name": "L-gulono-1,4-lactone dehydrogenase activity", "definition": "Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c. [PMID:18190525]"}
{"concept_id": "C2755293", "aliases": [], "types": ["T040"], "canonical_name": "regulation of seed development", "definition": "Any process that modulates the frequency, rate or extent of seed development. [PMID:19141706]"}
{"concept_id": "C2755294", "aliases": [], "types": ["T043"], "canonical_name": "cutin transport", "definition": "The directed movement of cutin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cutin, which consists of C16-18 fatty acids, is the major component of the cuticle that covers the plant surface. [PMID:17951461]"}
{"concept_id": "C2755295", "aliases": [], "types": ["T040"], "canonical_name": "response to histidine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus. [PMID:15889294]"}
{"concept_id": "C2755296", "aliases": [], "types": ["T040"], "canonical_name": "response to phenylalanine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus. [PMID:15889294]"}
{"concept_id": "C2755297", "aliases": ["low affinity nitrate transmembrane transporter activity"], "types": ["T044"], "canonical_name": "low-affinity nitrate transmembrane transporter activity", "definition": "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [PMID:19050168]"}
{"concept_id": "C2755299", "aliases": [], "types": ["T042"], "canonical_name": "petal vascular tissue pattern formation", "definition": "Vascular tissue pattern formation as it occurs in the petal of vascular plants. [PMID:17369435]"}
{"concept_id": "C2755300", "aliases": [], "types": ["T042"], "canonical_name": "sepal vascular tissue pattern formation", "definition": "Vascular tissue pattern formation as it occurs in the sepal of vascular plants. [PMID:17369435]"}
{"concept_id": "C2755301", "aliases": ["protein amino acid deglutathionylation"], "types": ["T044"], "canonical_name": "protein deglutathionylation", "definition": "The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage. [GOC:tb]"}
{"concept_id": "C2755302", "aliases": [], "types": ["T044"], "canonical_name": "flavonol 3-O-arabinosyltransferase activity", "definition": "Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside. [PMID:18757557]"}
{"concept_id": "C2755303", "aliases": [], "types": ["T042"], "canonical_name": "integument development", "definition": "The process whose specific outcome is the progression of the integument over time, from its formation to the mature structure. Integument is one of the layers of tissue that usually covers the ovule, enveloping the nucellus and forming the micropyle at the apex. [PMID:19054366, PO:0020021]"}
{"concept_id": "C2755304", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetonitrile nitrilase activity", "definition": "Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3. [RHEA:45776]"}
{"concept_id": "C2755305", "aliases": [], "types": ["T044"], "canonical_name": "cytokinin 9-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event. [KEGG_REACTION:R08369, PMID:15342621]"}
{"concept_id": "C2755306", "aliases": ["4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity"], "types": ["T044"], "canonical_name": "4,4-dimethyl-9beta,19-cyclopropylsterol oxidation", "definition": "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy, 4-beta-methyl-9beta,19-cyclopropylsterol + 3 NADP+ + 3 H2O. [GOC:pr, PMID:14653780]"}
{"concept_id": "C2755307", "aliases": ["4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity"], "types": ["T044"], "canonical_name": "4-alpha-methyl-delta7-sterol oxidation", "definition": "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O. [GOC:pr, PMID:14653780]"}
{"concept_id": "C2755308", "aliases": [], "types": ["T044"], "canonical_name": "3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity", "definition": "Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate. [PMID:19077143]"}
{"concept_id": "C2755309", "aliases": [], "types": ["T044"], "canonical_name": "4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity", "definition": "Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate. [PMID:19077143]"}
{"concept_id": "C2755310", "aliases": [], "types": ["T044"], "canonical_name": "5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity", "definition": "Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate. [PMID:19077143]"}
{"concept_id": "C2755311", "aliases": [], "types": ["T044"], "canonical_name": "7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity", "definition": "Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate. [PMID:19077143]"}
{"concept_id": "C2755312", "aliases": [], "types": ["T044"], "canonical_name": "8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity", "definition": "Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate. [PMID:19077143]"}
{"concept_id": "C2755313", "aliases": [], "types": ["T044"], "canonical_name": "indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity", "definition": "Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate. [PMID:19077143]"}
{"concept_id": "C2755314", "aliases": [], "types": ["T044"], "canonical_name": "spermidine:sinapoyl CoA N-acyltransferase activity", "definition": "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule. [PMID:19077165]"}
{"concept_id": "C2755315", "aliases": [], "types": ["T044"], "canonical_name": "spermidine:coumaroyl CoA N-acyltransferase activity", "definition": "Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule. [PMID:19077165]"}
{"concept_id": "C2755316", "aliases": [], "types": ["T044"], "canonical_name": "spermidine:caffeoyl CoA N-acyltransferase activity", "definition": "Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule. [PMID:19077165]"}
{"concept_id": "C2755317", "aliases": [], "types": ["T044"], "canonical_name": "spermidine:feruloyl CoA N-acyltransferase activity", "definition": "Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule. [PMID:19077165]"}
{"concept_id": "C2755318", "aliases": [], "types": ["T044"], "canonical_name": "caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule. [PMID:19077165]"}
{"concept_id": "C2755319", "aliases": [], "types": ["T044"], "canonical_name": "trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule. [PMID:19077165]"}
{"concept_id": "C2755320", "aliases": [], "types": ["T044"], "canonical_name": "tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule. [PMID:19077165]"}
{"concept_id": "C2755321", "aliases": ["cellobiose glucohydrolase activity", "D-cellobiose glucosidase activity"], "types": ["T044"], "canonical_name": "cellobiose glucosidase activity", "definition": "Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose. [PMID:15604686, RHEA:30679]"}
{"concept_id": "C2755322", "aliases": [], "types": ["T044"], "canonical_name": "4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity", "definition": "Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside. [PMID:15604686]"}
{"concept_id": "C2755323", "aliases": [], "types": ["T044"], "canonical_name": "esculin beta-glucosidase activity", "definition": "Catalysis of the hydrolysis of glucosidic link in esculin. [PMID:15604686]"}
{"concept_id": "C2755324", "aliases": [], "types": ["T044"], "canonical_name": "beta-gentiobiose beta-glucosidase activity", "definition": "Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose. [PMID:15604686]"}
{"concept_id": "C2755325", "aliases": [], "types": ["T045"], "canonical_name": "5S rDNA binding", "definition": "Binding to a 5S rDNA sequence, encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists. [PMID:12711688]"}
{"concept_id": "C2755326", "aliases": [], "types": ["T026"], "canonical_name": "signal recognition particle, chloroplast targeting", "definition": "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast. [PMID:17513500]"}
{"concept_id": "C2755327", "aliases": ["filament development"], "types": ["T042"], "canonical_name": "stamen filament development", "definition": "The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen. [PMID:19139039, PO:0009067]"}
{"concept_id": "C2755328", "aliases": [], "types": ["T044"], "canonical_name": "callose binding"}
{"concept_id": "C2755329", "aliases": [], "types": ["T044"], "canonical_name": "spermidine hydroxycinnamate conjugate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of spermidine hydroxycinnamate conjugates. [PMID:19077165]"}
{"concept_id": "C2755330", "aliases": [], "types": ["T044"], "canonical_name": "sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity", "definition": "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative. [PMID:19168716]"}
{"concept_id": "C2755331", "aliases": [], "types": ["T040"], "canonical_name": "regulation of primary metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. [PMID:19211694]"}
{"concept_id": "C2755332", "aliases": [], "types": ["T043"], "canonical_name": "regulation of raffinose metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving raffinose. [PMID:19211694]"}
{"concept_id": "C2755333", "aliases": [], "types": ["T042"], "canonical_name": "regulation of pollen tube growth", "definition": "Any process that modulates the frequency, rate or extent of pollen tube growth. [PMID:19208902]"}
{"concept_id": "C2755334", "aliases": [], "types": ["T044"], "canonical_name": "regulation of photorespiration", "definition": "Any process that modulates the rate, frequency or extent of photorespiration. Photorespiration is a light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. [GOC:tb]"}
{"concept_id": "C2755335", "aliases": ["response to trehalose-6-phosphate stimulus"], "types": ["T040"], "canonical_name": "response to trehalose-6-phosphate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus. [PMID:19193861]"}
{"concept_id": "C2755336", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylethanolamine-sterol O-acyltransferase activity", "definition": "Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine. [PMID:16020547]"}
{"concept_id": "C2755337", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidate-sterol O-acyltransferase activity", "definition": "Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate. [PMID:16020547]"}
{"concept_id": "C2755338", "aliases": [], "types": ["T044"], "canonical_name": "L-tryptophan:pyruvate aminotransferase activity", "definition": "Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine. [RHEA:27586]"}
{"concept_id": "C2755339", "aliases": [], "types": ["T044"], "canonical_name": "L-tyrosine:pyruvate aminotransferase activity", "definition": "Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine. [MetaCyc:RXN3O-4157]"}
{"concept_id": "C2755340", "aliases": ["L-methionine:alpha-ketoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "L-methionine:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate. [PMID:18394996]"}
{"concept_id": "C2755341", "aliases": ["L-glutamine:alpha-ketoglutarate aminotransferase activity"], "types": ["T044"], "canonical_name": "L-glutamine:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate. [PMID:18394996]"}
{"concept_id": "C2755342", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidyl-N-dimethylethanolamine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine. [EC:2.1.1.71, PMID:19366698]"}
{"concept_id": "C2755343", "aliases": [], "types": ["T044"], "canonical_name": "3-methylthiopropyl glucosinolate S-oxygenase activity", "definition": "Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate. [PMID:18799661]"}
{"concept_id": "C2755344", "aliases": [], "types": ["T044"], "canonical_name": "4-methylthiopropyl glucosinolate S-oxygenase activity", "definition": "Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate. [PMID:18799661]"}
{"concept_id": "C2755345", "aliases": [], "types": ["T044"], "canonical_name": "5-methylthiopropyl glucosinolate S-oxygenase activity", "definition": "Catalysis of the reaction: 5-methylthiopropyl-glucosinolate = 5-methylsulfinylpropyl-glucosinolate. [PMID:18799661]"}
{"concept_id": "C2755346", "aliases": [], "types": ["T044"], "canonical_name": "6-methylthiopropyl glucosinolate S-oxygenase activity", "definition": "Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate. [PMID:18799661]"}
{"concept_id": "C2755347", "aliases": [], "types": ["T044"], "canonical_name": "7-methylthiopropyl glucosinolate S-oxygenase activity", "definition": "Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate. [PMID:18799661]"}
{"concept_id": "C2755348", "aliases": [], "types": ["T044"], "canonical_name": "8-methylthiopropyl glucosinolate S-oxygenase activity", "definition": "Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate. [PMID:18799661]"}
{"concept_id": "C2755349", "aliases": ["S-alkylthiohydroximate C-S lyase activity"], "types": ["T044"], "canonical_name": "S-alkylthiohydroximate lyase activity", "definition": "Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate. [PMID:14871316]"}
{"concept_id": "C2755350", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetonitrile nitrile hydratase activity", "definition": "Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide. [EC:4.2.1.84, MetaCyc:RXN-7567, PMID:11607511, PMID:12430025]"}
{"concept_id": "C2755351", "aliases": ["sporopollenin biosynthesis"], "types": ["T044"], "canonical_name": "sporopollenin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer. [PMID:19218397]"}
{"concept_id": "C2755352", "aliases": [], "types": ["T045"], "definition": "The removal of a methyl group from one or more nucleotides within an DNA molecule. [PMID:17208187]", "canonical_name": "DNA demethylation"}
{"concept_id": "C2755353", "aliases": [], "types": ["T040"], "canonical_name": "seed growth", "definition": "The increase in size or mass of a seed. A seed is a propagating organ formed in the reproductive cycle of a spermatophyte, derived from the ovule and enclosing an embryo. [GOC:dhl, PO:0009010]"}
{"concept_id": "C2755354", "aliases": ["regulation of seed size"], "types": ["T040"], "canonical_name": "regulation of seed growth", "definition": "Any process that modulates the frequency, rate or extent of growth of the seed of an plant. [PMID:19141706]"}
{"concept_id": "C2755355", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of glycine hydroxymethyltransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. [EC:2.1.2.1, PMID:19223513]"}
{"concept_id": "C2755356", "aliases": [], "types": ["T044"], "canonical_name": "myosin XI tail binding", "definition": "Binding to the tail region of a myosin XI heavy chain. [PMID:18703495]"}
{"concept_id": "C2755357", "aliases": [], "types": ["T044"], "canonical_name": "glucuronoxylan glucuronosyltransferase activity", "definition": "Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule. [PMID:18980649]"}
{"concept_id": "C2755358", "aliases": ["cambial secondary growth"], "types": ["T040"], "canonical_name": "secondary growth", "definition": "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of secondary vascular tissues by the vascular cambium. [ISBN:0471245208, PMID:19074290, PO:0005598, PO:0025004]"}
{"concept_id": "C2755359", "aliases": [], "types": ["T044"], "canonical_name": "brassinosteroid sulfotransferase activity", "definition": "Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative. [PMID:10409637, PMID:17039368]"}
{"concept_id": "C2755360", "aliases": ["ER body organization and biogenesis", "endoplasmic reticulum body organization and biogenesis", "endoplasmic reticulum body organization", "ER body organisation"], "types": ["T043"], "canonical_name": "ER body organization", "definition": "A process that is carried out at the cellular level which results in the formation of ER (endoplasmic reticulum) body. ER body is a compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species. [PMID:18780803, PMID:19147648]"}
{"concept_id": "C2755361", "aliases": ["CAAX-box protein maturation", "farnesylated protein maturation"], "types": ["T043"], "definition": "A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase. [PMID:12039957, PMID:17114793, PMID:18641086]", "canonical_name": "CAAX-box protein processing"}
{"concept_id": "C2755362", "aliases": ["adenosine monophosphate transport"], "types": ["T043"], "canonical_name": "AMP transport", "definition": "The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [PMID:18923018]"}
{"concept_id": "C2755363", "aliases": ["adenosine monophosphate transmembrane transporter activity"], "types": ["T044"], "canonical_name": "AMP transmembrane transporter activity", "definition": "Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other. [PMID:18923018]"}
{"concept_id": "C2755364", "aliases": ["jasmonic acid-amino synthetase activity", "ja-amino synthetase activity", "jasmonyl-amino synthetase activity", "jasmonate-amino acid synthetase activity", "jasmonate:amino acid synthetase activity", "jasmonate-amido synthetase activity", "jasmonate-amino acid conjugate synthetase activity"], "types": ["T044"], "canonical_name": "jasmonate-amino synthetase activity", "definition": "Catalysis of the reaction: jasmonate + an amino acid = an amide-linked jasmonyl-amino acid conjugate. The substrates of this reaction include non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate). [PMID:15258265, PMID:17291501]"}
{"concept_id": "C2755365", "aliases": ["pheophytin pheophorbide hydrolase activity"], "types": ["T044"], "canonical_name": "pheophytinase activity", "definition": "Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide. [PMID:19304936]"}
{"concept_id": "C2755367", "aliases": [], "types": ["T039"], "canonical_name": "ovary septum development", "definition": "The process whose specific outcome is the progression of the ovary septum over time, from its formation to the mature structure. The ovary septum is the thin partition that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s). [PMID:17855426]"}
{"concept_id": "C2755368", "aliases": [], "types": ["T039"], "canonical_name": "fruit septum development", "definition": "The process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit. [GOC:dhl, PO:0005008]"}
{"concept_id": "C2755369", "aliases": [], "types": ["T039"], "canonical_name": "anther septum development", "definition": "The process whose specific outcome is the progression of the anther septum over time, from its formation to the mature structure. The anther septum is a thin partition or stretch of cells that are present in the anther dehiscence zone. [GOC:dhl, PO:0005010]"}
{"concept_id": "C2755370", "aliases": ["20S proteasome assembly"], "types": ["T044"], "canonical_name": "proteasome core complex assembly", "definition": "The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles. [PMID:12401807, PMID:17971041]"}
{"concept_id": "C2755371", "aliases": ["hydroxyjasmonic acid sulfotransferase activity", "OHJA sulfotransferase activity"], "types": ["T044"], "canonical_name": "hydroxyjasmonate sulfotransferase activity", "definition": "Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate. [EC:2.8.2.-, GOC:pmn_curators, MetaCyc:RXN-10451, MetaCyc:RXN-10453, PMID:12637544]"}
{"concept_id": "C2755372", "aliases": ["12-hydroxyjasmonate sulfotransferase activity"], "types": ["T044"], "canonical_name": "12-hydroxyjasmonate sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate. [GOC:pz, RHEA:52728]"}
{"concept_id": "C2755373", "aliases": [], "types": ["T044"], "canonical_name": "12-hydroxyjasmonic acid sulfotransferase activity"}
{"concept_id": "C2755374", "aliases": [], "types": ["T044"], "canonical_name": "12-OHJA sulfotransferase activity"}
{"concept_id": "C2755375", "aliases": ["fatty acid alpha-hydroxylase activity"], "types": ["T044"], "definition": "Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain. [PMID:19054355]", "canonical_name": "fatty acid 2-hydroxylase"}
{"concept_id": "C2755376", "aliases": [], "types": ["T044"], "canonical_name": "midchain alkane hydroxylase activity", "definition": "Catalysis of the conversion of an alkane to a secondary alcohol. [PMID:17905869]"}
{"concept_id": "C2755377", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to stress", "definition": "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:dhl]"}
{"concept_id": "C2755378", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to stress", "definition": "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:dhl]"}
{"concept_id": "C2755379", "aliases": [], "types": ["T043"], "canonical_name": "priming of cellular response to stress", "definition": "The process that enables cells to respond in a more rapid and robust manner than nonprimed cells to much lower levels of a stimulus indicating the organism is under stress. [PMID:19318610]"}
{"concept_id": "C2755380", "aliases": ["priming of stress response"], "types": ["T039"], "canonical_name": "priming of response to stress"}
{"concept_id": "C2755381", "aliases": ["DNA-directed RNA polymerase IVb complex", "DNA-directed RNA polymerase IVb complex location", "DNA-directed RNA polymerase V complex", "DNA-directed RNA polymerase V complex location", "RNA polymerase V complex location"], "types": ["T026"], "canonical_name": "RNA polymerase V complex", "definition": "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits. [GOC:krc, GOC:mtg_sensu, PMID:16140984, PMID:19110459]"}
{"concept_id": "C2755382", "aliases": [], "types": ["T044"], "canonical_name": "boron uptake transmembrane transporter activity"}
{"concept_id": "C2755383", "aliases": [], "types": ["T044"], "canonical_name": "boron efflux transmembrane transporter activity"}
{"concept_id": "C2755384", "aliases": [], "types": ["T043"], "canonical_name": "regulation of jasmonic acid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid. [GOC:dhl]"}
{"concept_id": "C2755385", "aliases": [], "types": ["T043"], "canonical_name": "regulation of jasmonic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid. [GOC:dhl]"}
{"concept_id": "C2755386", "aliases": [], "types": ["T039"], "canonical_name": "regulation of salicylic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid. [GOC:dhl]"}
{"concept_id": "C2755387", "aliases": [], "types": ["T044"], "canonical_name": "regulation of amino acid export", "definition": "Any process that modulates the frequency, rate or extent of amino acid export. Amino acid export is the directed movement of amino acids out of a cell or organelle. [PMID:20018597]"}
{"concept_id": "C2755388", "aliases": [], "types": ["T040"], "canonical_name": "amino acid homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of amino acid within an organism or cell. [PMID:19955263]"}
{"concept_id": "C2755389", "aliases": [], "types": ["T040"], "canonical_name": "cysteine homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of cysteine within an organism or cell. [PMID:19955263]"}
{"concept_id": "C2755390", "aliases": [], "types": ["T044"], "canonical_name": "L-cysteine desulfhydrase activity", "definition": "Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+. [MetaCyc:LCYSDESULF-RXN, PMID:19955263]"}
{"concept_id": "C2755391", "aliases": [], "types": ["T043"], "canonical_name": "root hair cell development", "definition": "The process whose specific outcome is the progression of a root hair cell over time, from its formation to the mature state. [PMID:19675148]"}
{"concept_id": "C2755392", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of response to water deprivation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to water deprivation. Response to water deprivation is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. [PMID:18835996]"}
{"concept_id": "C2755393", "aliases": ["negative regulation of translation in response to sucrose"], "types": ["T045"], "canonical_name": "sucrose induced translational repression", "definition": "Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level. [PMID:19403731]"}
{"concept_id": "C2755394", "aliases": ["S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity"], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity", "definition": "Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine. [MetaCyc:RXN-6722, PMID:10852939]"}
{"concept_id": "C2755395", "aliases": [], "types": ["T043"], "canonical_name": "formation by symbiont of stylet for nutrient acquisition from host"}
{"concept_id": "C2755408", "aliases": [], "types": ["T045"], "canonical_name": "replication fork arrest at tRNA locus", "definition": "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755413", "aliases": [], "types": ["T043"], "canonical_name": "regulation of linear element assembly", "definition": "Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase. [GOC:tb]"}
{"concept_id": "C2755415", "aliases": [], "types": ["T042"], "canonical_name": "hypoblast development", "definition": "The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755416", "aliases": [], "types": ["T042"], "canonical_name": "primitive streak formation", "definition": "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755417", "aliases": ["transforming growth factor beta receptor signalling pathway involved in primitive streak formation"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in primitive streak formation", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755418", "aliases": [], "types": ["T044"], "canonical_name": "TGFbeta signaling pathway involved in primitive streak formation"}
{"concept_id": "C2755419", "aliases": ["Wnt receptor signalling pathway involved in primitive streak formation", "Wnt-activated signaling pathway involved in primitive streak formation", "Wnt receptor signaling pathway involved in primitive streak formation"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in primitive streak formation", "definition": "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contribute to the formation of the primitive streak. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755420", "aliases": ["negative regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation"], "types": ["T044"], "canonical_name": "negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755421", "aliases": ["regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation"], "types": ["T039"], "canonical_name": "regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation", "definition": "Any process that modulates the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755422", "aliases": [], "types": ["T042"], "canonical_name": "leaflet formation", "definition": "The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755423", "aliases": ["positive regulation of leaflet formation by auxin mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of leaflet formation by auxin mediated signaling pathway", "definition": "Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755424", "aliases": [], "types": ["T038"], "canonical_name": "regulation of leaflet formation", "definition": "Any process that modulates the frequency, rate or extent of leaflet formation. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755425", "aliases": [], "types": ["T042"], "canonical_name": "anterior neural plate formation", "definition": "The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755426", "aliases": [], "types": ["T042"], "canonical_name": "posterior neural plate formation", "definition": "The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755429", "aliases": ["positive regulation of posterior neural plate formation by Wnt receptor signalling pathway", "positive regulation of posterior neural plate formation by Wnt-activated signaling pathway", "positive regulation of posterior neural plate formation by Wnt receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of posterior neural plate formation by Wnt signaling pathway", "definition": "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755430", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil chemotaxis", "definition": "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755431", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of neutrophil chemotaxis", "definition": "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755432", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of neutrophil chemotaxis", "definition": "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755433", "aliases": [], "types": ["T043"], "canonical_name": "regulation of monocyte chemotaxis", "definition": "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755434", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of monocyte chemotaxis", "definition": "Any process that increases the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755435", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of monocyte chemotaxis", "definition": "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755436", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion", "definition": "Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755437", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion", "definition": "Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755438", "aliases": [], "types": ["T044"], "canonical_name": "regulation of steroid hormone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755439", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of steroid hormone biosynthetic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755440", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of steroid hormone biosynthetic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755441", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of filamentous growth", "definition": "Any process that increases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755442", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chaperone-mediated protein complex assembly", "definition": "Any process that modulates the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755443", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of chaperone-mediated protein complex assembly", "definition": "Any process that increases the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755444", "aliases": ["regulation of protein kinase C signaling cascade", "regulation of protein kinase C signalling cascade"], "types": ["T044"], "canonical_name": "regulation of protein kinase C signaling", "definition": "Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755445", "aliases": ["positive regulation of protein kinase C signalling cascade", "positive regulation of protein kinase C signaling cascade"], "types": ["T044"], "canonical_name": "positive regulation of protein kinase C signaling", "definition": "Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755446", "aliases": ["negative regulation of protein kinase C signaling cascade", "negative regulation of protein kinase C signalling cascade"], "types": ["T044"], "canonical_name": "negative regulation of protein kinase C signaling", "definition": "Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755447", "aliases": [], "types": ["T045"], "canonical_name": "regulation of gene-specific transcription elongation from RNA polymerase II promoter"}
{"concept_id": "C2755448", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription elongation from RNA polymerase II promoter"}
{"concept_id": "C2755449", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of gene-specific transcription elongation from RNA polymerase II promoter"}
{"concept_id": "C2755450", "aliases": [], "types": ["T044"], "canonical_name": "tubulin deacetylation", "definition": "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755451", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tubulin deacetylation", "definition": "Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755452", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tubulin deacetylation", "definition": "Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755453", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of deacetylase activity", "definition": "Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755457", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell migration involved in sprouting angiogenesis", "definition": "Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2755458", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell migration involved in sprouting angiogenesis", "definition": "Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2755459", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell migration involved in sprouting angiogenesis", "definition": "Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C2755460", "aliases": ["regulation of chromatin silencing at centromere"], "types": ["T045"], "canonical_name": "regulation of pericentric heterochromatin assembly", "definition": "Any process that modulates the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755461", "aliases": ["positive regulation of chromatin silencing at centromere"], "types": ["T045"], "canonical_name": "positive regulation of pericentric heterochromatin assembly", "definition": "Any process that increases the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755462", "aliases": ["regulation of chromatin silencing at silent mating-type cassette"], "types": ["T045"], "canonical_name": "regulation of silent mating-type cassette heterochromatin assembly", "definition": "Any process that modulates the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755463", "aliases": ["positive regulation of chromatin silencing at silent mating-type cassette"], "types": ["T045"], "canonical_name": "positive regulation of silent mating-type cassette heterochromatin assembly", "definition": "Any process that increases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755464", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chlorophyll metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755465", "aliases": [], "types": ["T042"], "canonical_name": "root radial pattern formation", "definition": "The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755466", "aliases": [], "types": ["T042"], "canonical_name": "metaxylem development", "definition": "The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755467", "aliases": [], "types": ["T042"], "canonical_name": "protoxylem development", "definition": "The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755468", "aliases": [], "types": ["T038"], "canonical_name": "regulation of metaxylem development", "definition": "Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C2755470", "aliases": [], "types": ["T043"], "canonical_name": "regulation of trehalose metabolic process", "definition": "Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755471", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of microtubule nucleation", "definition": "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755472", "aliases": [], "types": ["T043"], "canonical_name": "activation of microtubule nucleation", "definition": "Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755474", "aliases": [], "types": ["T038"], "canonical_name": "regulation of anatomical structure size", "definition": "Any process that modulates the size of an anatomical structure. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755475", "aliases": [], "types": ["T038"], "canonical_name": "regulation of thalamus size", "definition": "Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755476", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell cycle process", "definition": "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755477", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ribosome biogenesis", "definition": "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755478", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ribosome biogenesis", "definition": "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755479", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ribosome biogenesis", "definition": "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755481", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of protein homodimerization activity", "definition": "Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755482", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein homodimerization activity", "definition": "Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755483", "aliases": [], "types": ["T039"], "canonical_name": "relaxation of skeletal muscle", "definition": "A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. [GOC:BHF, GOC:rl]"}
{"concept_id": "C2755484", "aliases": [], "types": ["T043"], "canonical_name": "foam cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755485", "aliases": [], "types": ["T043"], "canonical_name": "smooth muscle derived foam cell differentiation", "definition": "The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755486", "aliases": [], "types": ["T045"], "canonical_name": "translation regulator activity, nucleic acid binding", "definition": "Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. [GOC:dph, GOC:tb, GOC:vw]"}
{"concept_id": "C2755487", "aliases": ["positive regulation of MAPKKK cascade by fibroblast growth factor receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755488", "aliases": ["regulation of heart induction by regulation of canonical Wnt receptor signaling pathway", "regulation of heart induction by regulation of canonical Wnt-activated signaling pathway", "regulation of heart induction by regulation of canonical Wnt receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of heart induction by regulation of canonical Wnt signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:mtg_heart]"}
{"concept_id": "C2755489", "aliases": ["positive regulation of heart induction by negative regulation of canonical Wnt receptor signalling pathway", "positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway", "positive regulation of heart induction by negative regulation of canonical Wnt-activated signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of canonical Wnt signaling pathway that positively regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:mtg_heart, PMID:16860783]"}
{"concept_id": "C2755490", "aliases": [], "types": ["T043"], "canonical_name": "regulation of inclusion body assembly", "definition": "Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755491", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of inclusion body assembly", "definition": "Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755492", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein deubiquitination", "definition": "Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755493", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein deubiquitination", "definition": "Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755494", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peptide transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755495", "aliases": [], "types": ["T043"], "canonical_name": "regulation of oligopeptide transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755496", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dipeptide transport", "definition": "Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755497", "aliases": ["negative regulation of canonical Wnt receptor signaling pathway", "negative regulation of canonical Wnt-activated signaling pathway", "negative regulation of canonical Wnt receptor signalling pathway", "negative regulation of Wnt receptor signaling pathway through beta-catenin"], "types": ["T043"], "canonical_name": "negative regulation of canonical Wnt signaling pathway", "definition": "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755498", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of extracellular matrix disassembly", "definition": "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755499", "aliases": ["regulation of transmembrane receptor protein serine/threonine kinase signalling pathway"], "types": ["T044"], "canonical_name": "regulation of transmembrane receptor protein serine/threonine kinase signaling pathway", "definition": "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755500", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fungal-type cell wall beta-glucan biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755501", "aliases": [], "types": ["T043"], "canonical_name": "metanephric cap mesenchymal cell proliferation involved in metanephros development", "definition": "The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip. [GOC:dph, GOC:tb, GOC:yaf, PMID:19161241]"}
{"concept_id": "C2755502", "aliases": [], "types": ["T043"], "canonical_name": "regulation of metanephric cap mesenchymal cell proliferation", "definition": "Any process that modulates the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755503", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of metanephric cap mesenchymal cell proliferation", "definition": "Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755504", "aliases": ["regulation of decapentaplegic receptor signalling pathway", "regulation of decapentaplegic signaling pathway"], "types": ["T043"], "canonical_name": "regulation of decapentaplegic receptor signaling pathway"}
{"concept_id": "C2755505", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of decapentaplegic signaling pathway"}
{"concept_id": "C2755506", "aliases": ["negative regulation of decapentaplegic receptor signalling pathway", "negative regulation of decapentaplegic signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of decapentaplegic receptor signaling pathway"}
{"concept_id": "C2755507", "aliases": ["positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway", "definition": "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755508", "aliases": ["negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway", "definition": "Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755509", "aliases": [], "types": ["T042"], "canonical_name": "cochlea development", "definition": "The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755510", "aliases": [], "types": ["T040"], "canonical_name": "cochlea morphogenesis", "definition": "The process in which the cochlea is generated and organized. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755511", "aliases": ["pancreatic E cell differentiation"], "types": ["T043"], "canonical_name": "pancreatic epsilon cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755512", "aliases": [], "types": ["T043"], "canonical_name": "pancreatic E cell development", "definition": "The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755513", "aliases": [], "types": ["T043"], "canonical_name": "pancreatic E cell fate commitment", "definition": "The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755514", "aliases": [], "types": ["T043"], "canonical_name": "regulation of high-density lipoprotein particle assembly", "definition": "Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755515", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of high-density lipoprotein particle assembly", "definition": "Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755516", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell-substrate junction assembly", "definition": "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755517", "aliases": ["cargo selection into COPII-coated vesicle", "cargo loading into COPII-coated vesicle", "cargo loading into COPII vesicle"], "types": ["T044"], "canonical_name": "COPII-coated vesicle cargo loading", "definition": "The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi. [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb]"}
{"concept_id": "C2755518", "aliases": [], "types": ["T044"], "canonical_name": "COPII coat-cargo complex assembly"}
{"concept_id": "C2755519", "aliases": [], "types": ["T044"], "canonical_name": "regulation of COPII vesicle uncoating", "definition": "Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process in which COPII vesicle coat proteins are disassembled, and released. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755520", "aliases": [], "types": ["T044"], "canonical_name": "COPII vesicle uncoating", "definition": "The process in which COPII vesicle coat proteins are disassembled, and released. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755521", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis", "definition": "The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755522", "aliases": [], "types": ["T043"], "canonical_name": "COPII-coated vesicle budding", "definition": "The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755523", "aliases": [], "types": ["T043"], "canonical_name": "COPII vesicle budding"}
{"concept_id": "C2755524", "aliases": [], "types": ["T043"], "canonical_name": "ER exit"}
{"concept_id": "C2755525", "aliases": [], "types": ["T043"], "canonical_name": "ER vesicle budding"}
{"concept_id": "C2755527", "aliases": [], "types": ["T045"], "canonical_name": "C-5 methylation of cytosine", "definition": "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755528", "aliases": ["endosome to lysosome transport of LDL"], "types": ["T043"], "canonical_name": "endosome to lysosome transport of low-density lipoprotein particle", "definition": "The directed movement of low-density lipoprotein particle from endosomes to lysosomes. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755529", "aliases": ["receptor-mediated endocytosis of LDL"], "types": ["T043"], "canonical_name": "receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport"}
{"concept_id": "C2755530", "aliases": [], "types": ["T043"], "canonical_name": "vesicle-mediated cholesterol transport", "definition": "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755531", "aliases": ["lysosome to endoplasmic reticulum cholesterol transport"], "types": ["T043"], "canonical_name": "lysosome to ER cholesterol transport", "definition": "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C2755532", "aliases": [], "types": ["T043"], "canonical_name": "low-density lipoprotein particle disassembly involved in cholesterol transport", "definition": "The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755533", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol ester hydrolysis involved in cholesterol transport", "definition": "The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755534", "aliases": [], "types": ["T026"], "canonical_name": "lysosomal glycocalyx", "definition": "The polysaccharide-based coating on the inner side of a lysosomal membrane. It may be involved in protecting the membrane from digestion by lysosomal enzymes. [GOC:ascb_2009, GOC:dph, GOC:krc, GOC:tb, PMID:10521503, PMID:22809326, PMID:29367433]"}
{"concept_id": "C2755535", "aliases": [], "types": ["T045"], "canonical_name": "N-4 methylation of cytosine", "definition": "The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755536", "aliases": ["trans-synaptic adhesion"], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in synapse maturation", "definition": "The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755537", "aliases": [], "types": ["T043"], "canonical_name": "protein complex assembly involved in synapse maturation"}
{"concept_id": "C2755538", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of synapse maturation by synaptic transmission", "definition": "Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755539", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synapse maturation", "definition": "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755540", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of synapse maturation", "definition": "Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755541", "aliases": [], "types": ["T042"], "canonical_name": "tissue migration", "definition": "The process in which the population of cells that make up a tissue undergo directed movement. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755542", "aliases": [], "types": ["T042"], "canonical_name": "mesenchyme migration", "definition": "The process in which the population of cells that make up a mesenchyme undergo directed movement. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755543", "aliases": [], "types": ["T042"], "canonical_name": "epithelium migration", "definition": "The process in which the population of cells that make up an epithelium undergo directed movement. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755544", "aliases": [], "types": ["T042"], "canonical_name": "mesendoderm migration", "definition": "The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755545", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in mesendoderm migration", "definition": "The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755546", "aliases": [], "types": ["T043"], "canonical_name": "actin filament branching", "definition": "The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755547", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell-cell adhesion", "definition": "The attachment of an epithelial cell to another epithelial cell via adhesion molecules. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755548", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell-cell adhesion involved in epithelium migration", "definition": "The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755549", "aliases": ["regulation of actin cytoskeleton organisation by cell-cell adhesion"], "types": ["T043"], "canonical_name": "regulation of actin cytoskeleton organization by cell-cell adhesion", "definition": "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755550", "aliases": ["mitochondrial DNA packaging"], "types": ["T045"], "canonical_name": "mitochondrial chromosome packaging", "definition": "A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755551", "aliases": ["regulation of mitochondrial division"], "types": ["T043"], "canonical_name": "regulation of mitochondrial fission", "definition": "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755552", "aliases": ["positive regulation of mitochondrial division"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial fission", "definition": "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755553", "aliases": ["nucleoid organisation"], "types": ["T043"], "canonical_name": "nucleoid organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755554", "aliases": ["mitochondrial nucleoid organisation"], "types": ["T043"], "canonical_name": "mitochondrial nucleoid organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755558", "aliases": ["membrane scission"], "types": ["T043"], "canonical_name": "membrane fission", "definition": "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755559", "aliases": ["membrane fission involved in mitochondrial fission", "mitochondrial membrane scission"], "types": ["T043"], "canonical_name": "mitochondrial membrane fission", "definition": "A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755560", "aliases": ["establishment of protein localisation in membrane", "establishment of protein localization in membrane"], "types": ["T043"], "canonical_name": "establishment of protein localization to membrane", "definition": "The directed movement of a protein to a specific location in a membrane. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755561", "aliases": ["establishment of protein localisation in mitochondrial membrane", "establishment of protein localization in mitochondrial membrane"], "types": ["T043"], "canonical_name": "establishment of protein localization to mitochondrial membrane", "definition": "The directed movement of a protein to a specific location in the mitochondrial membrane. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755562", "aliases": ["establishment of protein localization in mitochondrial membrane involved in mitochondrial fission", "establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission"], "types": ["T043"], "canonical_name": "establishment of protein localization to mitochondrial membrane involved in mitochondrial fission", "definition": "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755563", "aliases": [], "types": ["T044"], "canonical_name": "regulation of sphingolipid biosynthetic process", "definition": "Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755564", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of sphingolipid biosynthetic process", "definition": "Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755565", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of sphingolipid biosynthetic process", "definition": "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755566", "aliases": [], "types": ["T043"], "canonical_name": "cellular sphingolipid homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of sphingolipids at the level of the cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755568", "aliases": ["endoplasmic reticulum membrane organisation"], "types": ["T043"], "canonical_name": "endoplasmic reticulum membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755569", "aliases": ["sphingolipid biosynthesis involved in endoplasmic reticulum membrane organisation"], "types": ["T044"], "canonical_name": "sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization", "definition": "The chemical reactions and pathways resulting in the formation of sphingolipids that contributes to endoplasmic reticulum membrane organization. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755570", "aliases": [], "types": ["T043"], "canonical_name": "Golgi to lysosome transport", "definition": "The directed movement of substances from the Golgi to lysosomes. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755571", "aliases": [], "types": ["T043"], "canonical_name": "Golgi ribbon formation", "definition": "The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755572", "aliases": [], "types": ["T043"], "canonical_name": "establishment of epithelial cell polarity", "definition": "The specification and formation of anisotropic intracellular organization of an epithelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755573", "aliases": [], "types": ["T043"], "canonical_name": "establishment of epithelial cell planar polarity", "definition": "The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755574", "aliases": [], "types": ["T043"], "canonical_name": "asymmetric Golgi ribbon formation", "definition": "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755575", "aliases": [], "types": ["T043"], "canonical_name": "regulation of secretion by asymmetric Golgi ribbon formation", "definition": "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755576", "aliases": [], "types": ["T043"], "canonical_name": "Golgi disassembly", "definition": "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755577", "aliases": [], "types": ["T043"], "canonical_name": "Golgi distribution to daughter cells", "definition": "Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755578", "aliases": [], "types": ["T043"], "canonical_name": "Golgi reassembly", "definition": "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755579", "aliases": ["regulation of spindle formation"], "types": ["T043"], "canonical_name": "regulation of spindle assembly", "definition": "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755580", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Golgi inheritance", "definition": "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755581", "aliases": [], "types": ["T043"], "canonical_name": "chondrocyte morphogenesis", "definition": "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755582", "aliases": ["microtubule cytoskeleton organisation involved in homologous chromosome segregation", "microtubule organization involved in chromosome pairing"], "types": ["T043"], "canonical_name": "microtubule cytoskeleton organization involved in homologous chromosome segregation", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing and precedes synapsis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755583", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptonemal complex assembly", "definition": "Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755584", "aliases": [], "types": ["T043"], "canonical_name": "organelle membrane fusion", "definition": "The joining of two lipid bilayers to form a single organelle membrane. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755585", "aliases": [], "types": ["T038"], "canonical_name": "regulation of establishment of planar polarity", "definition": "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755586", "aliases": ["microtubule cytoskeleton organisation involved in establishment of planar polarity"], "types": ["T043"], "canonical_name": "microtubule cytoskeleton organization involved in establishment of planar polarity", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755587", "aliases": [], "types": ["T042"], "canonical_name": "establishment of planar polarity involved in neural tube closure", "definition": "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755588", "aliases": [], "types": ["T040"], "canonical_name": "regulation of establishment of planar polarity involved in neural tube closure", "definition": "Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755589", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in neural tube closure", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755590", "aliases": ["positive regulation of thiamin biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of thiamine biosynthetic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755591", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cholesterol metabolic process", "definition": "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755592", "aliases": [], "types": ["T043"], "canonical_name": "regulation of secretion of lysosomal enzymes", "definition": "Any process that modulates the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755593", "aliases": [], "types": ["T042"], "canonical_name": "regulation of kidney development", "definition": "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755594", "aliases": [], "types": ["T038"], "canonical_name": "regulation of nephrogenesis"}
{"concept_id": "C2755595", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of kidney development", "definition": "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755596", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of nephrogenesis"}
{"concept_id": "C2755597", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of kidney development", "definition": "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755598", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of nephrogenesis"}
{"concept_id": "C2755599", "aliases": [], "types": ["T038"], "canonical_name": "regulation of pancreatic juice secretion", "definition": "Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755600", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of pancreatic juice secretion", "definition": "Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755601", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of pancreatic juice secretion", "definition": "Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755602", "aliases": [], "types": ["T043"], "canonical_name": "regulation of branching involved in ureteric bud morphogenesis", "definition": "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755603", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of branching involved in ureteric bud morphogenesis", "definition": "Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755604", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of branching involved in ureteric bud morphogenesis", "definition": "Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755605", "aliases": [], "types": ["T038"], "canonical_name": "regulation of glomerulus development", "definition": "Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755606", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of glomerulus development", "definition": "Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755607", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of glomerulus development", "definition": "Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C2755612", "aliases": [], "types": ["T043"], "canonical_name": "regulation of release of cytochrome c from mitochondria", "definition": "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2755613", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of release of cytochrome c from mitochondria", "definition": "Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2755614", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of release of cytochrome c from mitochondria", "definition": "Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C2755618", "aliases": ["protein localisation to nuclear pore"], "types": ["T043"], "canonical_name": "protein localization to nuclear pore", "definition": "A process in which a protein is transported to, or maintained in, a nuclear pore. [GOC:dph, GOC:rb, GOC:tb]"}
{"concept_id": "C2755619", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cholesterol metabolic process", "definition": "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2755620", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cholesterol metabolic process", "definition": "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2755621", "aliases": [], "types": ["T044"], "canonical_name": "regulation of triglyceride metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2755622", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of triglyceride metabolic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2755623", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of triglyceride metabolic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C2755624", "aliases": ["regulation of establishment of BBB"], "types": ["T043"], "canonical_name": "regulation of establishment of blood-brain barrier", "definition": "Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755625", "aliases": ["positive regulation of establishment of BBB"], "types": ["T043"], "canonical_name": "positive regulation of establishment of blood-brain barrier", "definition": "Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755626", "aliases": ["negative regulation of establishment of BBB"], "types": ["T043"], "canonical_name": "negative regulation of establishment of blood-brain barrier", "definition": "Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755627", "aliases": [], "types": ["T038"], "canonical_name": "regulation of radial pattern formation", "definition": "Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur. [GOC:tb]"}
{"concept_id": "C2755628", "aliases": [], "types": ["T038"], "canonical_name": "regulation of radial pattern specification"}
{"concept_id": "C2755629", "aliases": [], "types": ["T040"], "canonical_name": "spongiotrophoblast layer developmental growth", "definition": "The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755630", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity", "definition": "Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755631", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity", "definition": "Any process that increases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755632", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity", "definition": "Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755633", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of lipid kinase activity", "definition": "Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755634", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lipid kinase activity", "definition": "Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755635", "aliases": ["chromosome localisation to nuclear envelope involved in homologous chromosome segregation"], "types": ["T043"], "canonical_name": "chromosome localization to nuclear envelope involved in homologous chromosome segregation", "definition": "The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis. [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:19913287]"}
{"concept_id": "C2755636", "aliases": [], "types": ["T043"], "canonical_name": "mitotic spindle-templated microtubule nucleation", "definition": "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755637", "aliases": [], "types": ["T043"], "canonical_name": "centrosome-templated microtubule nucleation", "definition": "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755638", "aliases": [], "types": ["T043"], "canonical_name": "chromatin-templated microtubule nucleation", "definition": "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755639", "aliases": ["regulation of spindle organisation"], "types": ["T043"], "canonical_name": "regulation of spindle organization", "definition": "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755640", "aliases": [], "types": ["T043"], "canonical_name": "regulation of spindle density", "definition": "Any process that modulates the number of microtubules in a given region of the spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755641", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microtubule nucleation by Ran protein signal transduction", "definition": "The series of molecular signals in which a Ran GTPase relays a signal resulting in the modulation of the rate, frequency or extent of microtubule nucleation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755642", "aliases": ["regulation of phytochrome signaling pathway", "regulation of red or far-red light signalling pathway"], "types": ["T043"], "canonical_name": "regulation of red or far-red light signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. [GOC:tb]"}
{"concept_id": "C2755643", "aliases": ["positive regulation of phytochrome signaling pathway", "positive regulation of red or far-red light signalling pathway"], "types": ["T043"], "canonical_name": "positive regulation of red or far-red light signaling pathway", "definition": "Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. [GOC:tb]"}
{"concept_id": "C2755644", "aliases": ["negative regulation of phytochrome signaling pathway", "negative regulation of red or far-red light signalling pathway"], "types": ["T043"], "canonical_name": "negative regulation of red or far-red light signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. [GOC:tb]"}
{"concept_id": "C2755645", "aliases": [], "types": ["T043"], "canonical_name": "regulation of centromere complex assembly", "definition": "Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755646", "aliases": [], "types": ["T043"], "canonical_name": "centromere licensing"}
{"concept_id": "C2755647", "aliases": [], "types": ["T043"], "canonical_name": "regulation of spindle checkpoint", "definition": "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755648", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of spindle checkpoint", "definition": "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755649", "aliases": [], "types": ["T043"], "canonical_name": "spindle checkpoint activation"}
{"concept_id": "C2755650", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of spindle checkpoint", "definition": "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755651", "aliases": [], "types": ["T043"], "canonical_name": "spindle checkpoint silencing"}
{"concept_id": "C2755652", "aliases": [], "types": ["T043"], "canonical_name": "regulation of kinetochore assembly", "definition": "Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755653", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chromosome-kinetochore attachment"}
{"concept_id": "C2755654", "aliases": ["regulation of chromosome congression"], "types": ["T043"], "canonical_name": "regulation of metaphase plate congression", "definition": "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755656", "aliases": [], "types": ["T043"], "canonical_name": "regulation of arachidonic acid secretion", "definition": "Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755657", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of arachidonic acid secretion", "definition": "Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755658", "aliases": [], "types": ["T043"], "canonical_name": "regulation of histone H4 acetylation", "definition": "Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755659", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of histone H4 acetylation", "definition": "Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755660", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of histone H4 acetylation", "definition": "Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755661", "aliases": ["retinoic acid receptor signalling pathway involved in somitogenesis"], "types": ["T044"], "canonical_name": "retinoic acid receptor signaling pathway involved in somitogenesis", "definition": "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755662", "aliases": ["fibroblast growth factor receptor signalling pathway involved in somitogenesis"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in somitogenesis", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755663", "aliases": ["Wnt-activated signaling pathway involved in somitogenesis", "Wnt receptor signaling pathway involved in somitogenesis", "Wnt receptor signalling"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in somitogenesis", "definition": "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755664", "aliases": [], "types": ["T040"], "canonical_name": "axis elongation involved in somitogenesis", "definition": "The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755665", "aliases": [], "types": ["T040"], "canonical_name": "convergent extension involved in somitogenesis", "definition": "The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755667", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in somitogenic axis elongation", "definition": "Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755668", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell motility involved in somitogenic axis elongation"}
{"concept_id": "C2755669", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in establishment of planar polarity", "definition": "The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755670", "aliases": ["protein localisation involved in establishment of planar polarity"], "types": ["T043"], "canonical_name": "protein localization involved in establishment of planar polarity", "definition": "Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755671", "aliases": [], "types": ["T042"], "canonical_name": "epithelium migration involved in imaginal disc-derived wing morphogenesis", "definition": "The process in which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755672", "aliases": [], "types": ["T040"], "canonical_name": "convergent extension involved in imaginal disc-derived wing morphogenesis", "definition": "The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755673", "aliases": [], "types": ["T043"], "canonical_name": "cell elongation involved in imaginal disc-derived wing morphogenesis", "definition": "The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755674", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in imaginal disc-derived wing morphogenesis", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755675", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis", "definition": "Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C2755676", "aliases": [], "types": ["T042"], "canonical_name": "regulation of muscle system process", "definition": "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755677", "aliases": ["negative regulation of mitochondrial division"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial fission", "definition": "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [GOC:sl, GOC:tb]"}
{"concept_id": "C2755678", "aliases": [], "types": ["T042"], "canonical_name": "regulation of retinal ganglion cell axon guidance", "definition": "Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:tb, GOC:yaf]"}
{"concept_id": "C2755679", "aliases": ["axon growth cone collapse"], "types": ["T043"], "canonical_name": "negative regulation of retinal ganglion cell axon guidance", "definition": "Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:tb, GOC:yaf]"}
{"concept_id": "C2755680", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of inclusion body assembly", "definition": "Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. [GOC:tb]"}
{"concept_id": "C2755681", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription-coupled nucleotide-excision repair", "definition": "Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. [GOC:tb]"}
{"concept_id": "C2755682", "aliases": ["positive regulation of canonical Wnt receptor signalling pathway", "positive regulation of canonical Wnt-activated signaling pathway", "positive regulation of Wnt receptor signaling pathway through beta-catenin", "positive regulation of canonical Wnt receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of canonical Wnt signaling pathway", "definition": "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb]"}
{"concept_id": "C2755683", "aliases": [], "types": ["T043"], "canonical_name": "regulation of immune complex clearance by monocytes and macrophages", "definition": "Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages. [GOC:tb]"}
{"concept_id": "C2755684", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of immune complex clearance by monocytes and macrophages", "definition": "Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages. [GOC:BHF]"}
{"concept_id": "C2755685", "aliases": [], "types": ["T044"], "canonical_name": "regulation of mitotic cell cycle spindle assembly checkpoint", "definition": "Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C2755686", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of mitotic cell cycle spindle assembly checkpoint", "definition": "Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. [GOC:mah, GOC:vw]"}
{"concept_id": "C2755687", "aliases": [], "types": ["T044"], "canonical_name": "activation of mitotic cell cycle spindle assembly checkpoint", "definition": "Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint. [GOC:mah, GOC:vw]"}
{"concept_id": "C2755688", "aliases": [], "types": ["T043"], "canonical_name": "fibroblast growth factor production", "definition": "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]"}
{"concept_id": "C2755689", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fibroblast growth factor production", "definition": "Any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]"}
{"concept_id": "C2755690", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of fibroblast growth factor production", "definition": "Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]"}
{"concept_id": "C2755691", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of fibroblast growth factor production", "definition": "Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]"}
{"concept_id": "C2755692", "aliases": [], "types": ["T043"], "canonical_name": "regulation of somatostatin secretion", "definition": "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. [GOC:BHF]"}
{"concept_id": "C2755693", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of somatostatin secretion", "definition": "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. [GOC:BHF]"}
{"concept_id": "C2755694", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of somatostatin secretion", "definition": "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. [GOC:BHF]"}
{"concept_id": "C2755695", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peptide hormone secretion", "definition": "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. [GOC:tb]"}
{"concept_id": "C2755696", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of peptide hormone secretion", "definition": "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. [GOC:tb]"}
{"concept_id": "C2755697", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of peptide hormone secretion", "definition": "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. [GOC:tb]"}
{"concept_id": "C2755698", "aliases": ["regulation of calcium ion import"], "types": ["T043"], "canonical_name": "regulation of calcium ion import", "definition": "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. [GOC:BHF]"}
{"concept_id": "C2755699", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of calcium ion import", "definition": "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. [GOC:BHF]"}
{"concept_id": "C2755700", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of calcium ion import", "definition": "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. [GOC:BHF]"}
{"concept_id": "C2755701", "aliases": ["activation of transcription involved in G2/M transition of mitotic cell cycle", "activation of G2/M-specific transcription in the mitotic cell cycle", "activation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle", "up-regulation of transcription involved in G2/M transition of mitotic cell cycle", "positive regulation of G2/M-specific transcription in the mitotic cell cycle", "up-regulation of G2/M-specific transcription in the mitotic cell cycle", "up-regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle", "positive regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle"], "types": ["T045"], "canonical_name": "positive regulation of transcription involved in G2/M transition of mitotic cell cycle", "definition": "Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle. [GOC:rn, PMID:10747051, PMID:10894548, PMID:10899128, PMID:10959837]"}
{"concept_id": "C2755706", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to growth factor stimulus", "definition": "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. [GOC:tb]"}
{"concept_id": "C2755707", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular response to growth factor stimulus", "definition": "Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. [GOC:BHF]"}
{"concept_id": "C2755708", "aliases": [], "types": ["T043"], "canonical_name": "regulation of osteoclast proliferation", "definition": "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. [GOC:tb]"}
{"concept_id": "C2755709", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of osteoclast proliferation", "definition": "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. [GOC:tb]"}
{"concept_id": "C2755710", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of osteoclast proliferation", "definition": "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. [GOC:tb]"}
{"concept_id": "C2755711", "aliases": ["nucleoskeleton anchoring at nuclear membrane"], "types": ["T043"], "canonical_name": "nuclear matrix anchoring at nuclear membrane", "definition": "The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane. [GOC:tb]"}
{"concept_id": "C2755712", "aliases": ["regulation of transcription by nitrogen catabolites"], "types": ["T045"], "canonical_name": "nitrogen catabolite regulation of transcription", "definition": "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. [GOC:mah, GOC:rb, PMID:19104072]"}
{"concept_id": "C2755713", "aliases": ["positive regulation of transcription by nitrogen catabolites"], "types": ["T045"], "canonical_name": "nitrogen catabolite activation of transcription", "definition": "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. [GOC:mah, GOC:rb, PMID:19104072]"}
{"concept_id": "C2755714", "aliases": ["negative regulation of transcription by nitrogen catabolites", "nitrogen catabolite repression"], "types": ["T045"], "canonical_name": "nitrogen catabolite repression of transcription", "definition": "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. [GOC:mah, GOC:rb, PMID:19104072]"}
{"concept_id": "C2755715", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mitochondrial DNA replication", "definition": "Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion. [GOC:tb]"}
{"concept_id": "C2755716", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mitochondrial DNA replication", "definition": "Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion. [GOC:tb]"}
{"concept_id": "C2755717", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial DNA replication", "definition": "Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion. [GOC:tb]"}
{"concept_id": "C2755718", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neural crest formation", "definition": "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. [GOC:tb]"}
{"concept_id": "C2755719", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of neural crest formation", "definition": "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. [GOC:tb]"}
{"concept_id": "C2755720", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of neural crest formation", "definition": "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. [GOC:tb]"}
{"concept_id": "C2755722", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of wound healing", "definition": "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:BHF]"}
{"concept_id": "C2755724", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription involved in G2/M transition of mitotic cell cycle", "definition": "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C2755725", "aliases": ["MAPKKK cascade during sporulation"], "types": ["T043"], "canonical_name": "MAPKKK cascade during sporulation"}
{"concept_id": "C2755730", "aliases": [], "types": ["T044"], "canonical_name": "H4/H2A acetyltransferase activity"}
{"concept_id": "C2755731", "aliases": [], "types": ["T045"], "canonical_name": "conversion of mitochondrial met-tRNAf to fmet-tRNA"}
{"concept_id": "C2755732", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial N-terminal peptidyl-methionine N-formylation"}
{"concept_id": "C2755733", "aliases": [], "types": ["T045"], "canonical_name": "N-terminal peptidyl-methionine N-formylation"}
{"concept_id": "C2755734", "aliases": [], "types": ["T044"], "canonical_name": "hydroxylase activity"}
{"concept_id": "C2755735", "aliases": [], "types": ["T044"], "canonical_name": "secretory plant peroxidase activity"}
{"concept_id": "C2755736", "aliases": [], "types": ["T044"], "canonical_name": "fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity"}
{"concept_id": "C2755737", "aliases": [], "types": ["T044"], "canonical_name": "anaphase-promoting complex activity"}
{"concept_id": "C2755741", "aliases": ["purinoceptor"], "types": ["T044"], "canonical_name": "purinoreceptor"}
{"concept_id": "C2755742", "aliases": [], "types": ["T044"], "canonical_name": "autocrine activity"}
{"concept_id": "C2755743", "aliases": [], "types": ["T044"], "canonical_name": "paracrine activity"}
{"concept_id": "C2755744", "aliases": [], "types": ["T044"], "canonical_name": "structural protein of chorion"}
{"concept_id": "C2755746", "aliases": [], "types": ["T044"], "canonical_name": "water transmembrane transporter activity", "definition": "Enables the transfer of water (H2O) from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C2755747", "aliases": ["PIP3 binding"], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,4,5-trisphosphate binding", "definition": "Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. [GOC:bf, GOC:jl]"}
{"concept_id": "C2755748", "aliases": [], "types": ["T026"], "canonical_name": "nucleocytoplasm"}
{"concept_id": "C2755749", "aliases": ["major spliceosomal complex", "major (U2-type) spliceosomal complex location", "U2-type spliceosomal complex location", "major spliceosomal complex location", "major (U2-type) spliceosomal complex"], "types": ["T026"], "canonical_name": "U2-type spliceosomal complex", "definition": "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. [GOC:krc, GOC:mah, PMID:11343900]"}
{"concept_id": "C2755750", "aliases": ["minor spliceosomal complex location", "minor spliceosomal complex", "minor (U12-type) spliceosomal complex location", "minor (U12-type) spliceosomal complex", "U12-type spliceosomal complex location"], "types": ["T026"], "canonical_name": "U12-type spliceosomal complex", "definition": "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]"}
{"concept_id": "C2755751", "aliases": ["AT-AC spliceosomal complex location"], "types": ["T026"], "canonical_name": "AT-AC spliceosomal complex"}
{"concept_id": "C2755753", "aliases": ["Sec61 translocon complex location", "Sec61p-Sbh1p-Sss1p complex", "Sec61p-Sbh1p-Sss1p complex location"], "types": ["T026"], "canonical_name": "Sec61 translocon complex", "definition": "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events. [GOC:mah, PMID:18166647, PMID:32820719, PMID:33960686]"}
{"concept_id": "C2755754", "aliases": [], "types": ["T044"], "canonical_name": "modifed Embden-Meyerhof pathway"}
{"concept_id": "C2755755", "aliases": ["regulation of gene expression by genetic imprinting", "regulation of gene expression by DNA imprinting"], "types": ["T043"], "canonical_name": "regulation of gene expression by genomic imprinting", "definition": "An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles. [PMID:11498578, PMID:31896690, PMID:7502071]"}
{"concept_id": "C2755756", "aliases": [], "types": ["T043"], "canonical_name": "cellular transcription"}
{"concept_id": "C2755757", "aliases": [], "types": ["T044"], "canonical_name": "N(alpha)-terminal acetylation"}
{"concept_id": "C2755769", "aliases": [], "types": ["T043"], "canonical_name": "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "definition": "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. [ISBN:0198506732]"}
{"concept_id": "C2755770", "aliases": ["hh protein processing"], "types": ["T043"], "canonical_name": "patched ligand maturation", "definition": "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups. [PMID:15057936]"}
{"concept_id": "C2755771", "aliases": [], "types": ["T039"], "canonical_name": "Nebenkern assembly", "definition": "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern. [GOC:bf, ISBN:0879694238, PMID:9550716]"}
{"concept_id": "C2755772", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of oocyte identity"}
{"concept_id": "C2755773", "aliases": [], "types": ["T042"], "canonical_name": "nurse cell to oocyte transport"}
{"concept_id": "C2755774", "aliases": [], "types": ["T043"], "canonical_name": "female germline ring canal formation", "definition": "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst. [ISBN:0879694238]"}
{"concept_id": "C2755775", "aliases": [], "types": ["T043"], "canonical_name": "nurse cell ring canal formation"}
{"concept_id": "C2755776", "aliases": [], "types": ["T040"], "canonical_name": "zygotic specification of dorsal/ventral axis", "definition": "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote. [GOC:bf]"}
{"concept_id": "C2755778", "aliases": [], "types": ["T043"], "canonical_name": "anterior compartment pattern formation", "definition": "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C2755779", "aliases": [], "types": ["T043"], "canonical_name": "anterior compartment pattern specification"}
{"concept_id": "C2755780", "aliases": [], "types": ["T043"], "canonical_name": "axon chemotaxis"}
{"concept_id": "C2755781", "aliases": [], "types": ["T043"], "canonical_name": "tracheal cell fate determination"}
{"concept_id": "C2755783", "aliases": [], "types": ["T043"], "canonical_name": "tracheal placode cell fate determination"}
{"concept_id": "C2755784", "aliases": [], "types": ["T043"], "canonical_name": "tracheal cell migration"}
{"concept_id": "C2755785", "aliases": [], "types": ["T043"], "canonical_name": "tracheal epithelial cell migration"}
{"concept_id": "C2755789", "aliases": ["mammalian spliceosomal complex E location", "mammalian spliceosomal E complex location", "mammalian spliceosomal complex E"], "types": ["T026"], "canonical_name": "mammalian spliceosomal E complex"}
{"concept_id": "C2755790", "aliases": ["yeast spliceosomal complex CC location"], "types": ["T026"], "canonical_name": "yeast spliceosomal complex CC"}
{"concept_id": "C2755791", "aliases": ["bud site selection/establishment of cell polarity"], "types": ["T043"], "canonical_name": "bud site selection/establishment of cell polarity"}
{"concept_id": "C2755792", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of larval cuticle"}
{"concept_id": "C2755793", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of pupal cuticle"}
{"concept_id": "C2755794", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of adult cuticle"}
{"concept_id": "C2755796", "aliases": [], "types": ["T042"], "canonical_name": "dorsal/ventral axis determination, follicular epithelium"}
{"concept_id": "C2755797", "aliases": ["G-protein coupled amine receptor activity", "amine receptor activity, G-protein coupled"], "types": ["T044"], "canonical_name": "G protein-coupled amine receptor activity", "definition": "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph]"}
{"concept_id": "C2755798", "aliases": [], "types": ["T043"], "canonical_name": "female germline ring canal formation, actin assembly", "definition": "Recruitment and organization of actin filaments in female germline ring canals. [ISBN:0879694238]"}
{"concept_id": "C2755799", "aliases": [], "types": ["T043"], "canonical_name": "nurse cell ring canal formation, actin assembly"}
{"concept_id": "C2755800", "aliases": [], "types": ["T043"], "canonical_name": "ovarian ring canal formation, actin assembly"}
{"concept_id": "C2755801", "aliases": [], "types": ["T043"], "canonical_name": "female germline ring canal stabilization", "definition": "Maintenance of the structural integrity of the ring canals connecting the female germline cyst. [GOC:curators]"}
{"concept_id": "C2755802", "aliases": [], "types": ["T043"], "canonical_name": "nurse cell ring canal stabilization"}
{"concept_id": "C2755803", "aliases": [], "types": ["T038"], "canonical_name": "determination of adult lifespan", "definition": "The pathways that regulate the duration of the adult phase of the life-cycle of an animal. [PMID:25561524, PMID:273723695, PMID:3424805]"}
{"concept_id": "C2755804", "aliases": [], "types": ["T044"], "canonical_name": "embryonic cuticle anabolism"}
{"concept_id": "C2755805", "aliases": [], "types": ["T044"], "canonical_name": "embryonic cuticle biosynthetic process"}
{"concept_id": "C2755806", "aliases": [], "types": ["T044"], "canonical_name": "embryonic cuticle formation"}
{"concept_id": "C2755807", "aliases": [], "types": ["T044"], "canonical_name": "embryonic cuticle synthesis"}
{"concept_id": "C2755808", "aliases": [], "types": ["T044"], "canonical_name": "larval cuticle anabolism"}
{"concept_id": "C2755809", "aliases": [], "types": ["T044"], "canonical_name": "larval cuticle biosynthetic process"}
{"concept_id": "C2755810", "aliases": [], "types": ["T044"], "canonical_name": "larval cuticle formation"}
{"concept_id": "C2755811", "aliases": [], "types": ["T044"], "canonical_name": "larval cuticle synthesis"}
{"concept_id": "C2755812", "aliases": [], "types": ["T044"], "canonical_name": "pupal cuticle anabolism"}
{"concept_id": "C2755813", "aliases": [], "types": ["T044"], "canonical_name": "pupal cuticle formation"}
{"concept_id": "C2755814", "aliases": [], "types": ["T044"], "canonical_name": "pupal cuticle synthesis"}
{"concept_id": "C2755815", "aliases": ["adult cuticle formation", "adult cuticle biosynthetic process", "adult cuticle synthesis"], "types": ["T044"], "canonical_name": "adult cuticle anabolism"}
{"concept_id": "C2755816", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen/sucrose transporter activity"}
{"concept_id": "C2755817", "aliases": [], "types": ["T042"], "canonical_name": "hypodermis development"}
{"concept_id": "C2755818", "aliases": [], "types": ["T040"], "canonical_name": "anterior/posterior axis specification, embryo", "definition": "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]"}
{"concept_id": "C2755821", "aliases": [], "types": ["T045"], "canonical_name": "Barr body formation"}
{"concept_id": "C2755823", "aliases": ["pre-mRNA splicing factor activity"], "types": ["T045"], "canonical_name": "pre-mRNA splicing factor activity", "definition": "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA. [GOC:jl]"}
{"concept_id": "C2755824", "aliases": [], "types": ["T045"], "canonical_name": "spliceosomal snRNP assembly", "definition": "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. [GOC:krc, GOC:mah, ISBN:0879695897]"}
{"concept_id": "C2755825", "aliases": ["karyogamy involved in conjugation without cellular fusion"], "types": ["T043"], "canonical_name": "karyogamy involved in conjugation with mutual genetic exchange", "definition": "During sexual reproduction, the creation of a single nucleus from two nuclei as a result of fusing the nuclear envelopes that surround each nuclei. This takes place following the mutual exchange of one of the two nuclei produced by the mitosis that follows the second meiotic nuclear division. This occurs in ciliated protozoans such as Tetrahymena. [GOC:mah, GOC:pg]"}
{"concept_id": "C2755826", "aliases": ["nuclear migration involved in conjugation without cellular fusion"], "types": ["T043"], "canonical_name": "nuclear migration involved in conjugation with mutual genetic exchange", "definition": "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion. [GOC:clt, GOC:mah]"}
{"concept_id": "C2755827", "aliases": [], "types": ["T044"], "canonical_name": "pheromone-dependent signal transduction involved in conjugation with cellular fusion", "definition": "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae. [GOC:clt]"}
{"concept_id": "C2755828", "aliases": [], "types": ["T044"], "canonical_name": "transduction of mating signal"}
{"concept_id": "C2755829", "aliases": [], "types": ["T039"], "canonical_name": "cell morphogenesis involved in conjugation with cellular fusion", "definition": "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion. [GOC:clt]"}
{"concept_id": "C2755830", "aliases": ["response to pheromone triggering conjugation without cellular fusion"], "types": ["T043"], "canonical_name": "response to pheromone regulating conjugation with mutual genetic exchange", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion. [GOC:clt]"}
{"concept_id": "C2755832", "aliases": ["agglutination involved in conjugation without cellular fusion", "sexual flocculation"], "types": ["T043"], "canonical_name": "agglutination involved in conjugation with mutual genetic exchange", "definition": "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation without cellular fusion of a unicellular organism. [GOC:elh]"}
{"concept_id": "C2755837", "aliases": [], "types": ["T026"], "canonical_name": "flagellar basal body"}
{"concept_id": "C2755838", "aliases": [], "types": ["T026"], "canonical_name": "flagellar basal body, mounting plate"}
{"concept_id": "C2755839", "aliases": ["reaction centre"], "types": ["T026"], "canonical_name": "reaction center"}
{"concept_id": "C2755841", "aliases": ["determination of symmetry"], "types": ["T042"], "canonical_name": "specification of symmetry", "definition": "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. [GOC:go_curators]"}
{"concept_id": "C2755843", "aliases": [], "types": ["T042"], "canonical_name": "hypodermal cell differentiation"}
{"concept_id": "C2755844", "aliases": [], "types": ["T043"], "canonical_name": "hypodermal cell fate specification"}
{"concept_id": "C2755848", "aliases": [], "types": ["T042"], "canonical_name": "vascular tissue development"}
{"concept_id": "C2755851", "aliases": ["dehydrogenase complex location"], "types": ["T026"], "canonical_name": "dehydrogenase complex"}
{"concept_id": "C2755852", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)H dehydrogenase complex (plastoquinone) assembly"}
{"concept_id": "C2755853", "aliases": [], "types": ["T044"], "canonical_name": "chlorophyll catabolite transmembrane transporter activity", "definition": "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other. [PMID:9681016]"}
{"concept_id": "C2755856", "aliases": [], "types": ["T045"], "canonical_name": "regulation of gene product expression"}
{"concept_id": "C2755857", "aliases": [], "types": ["T045"], "canonical_name": "regulation of protein expression"}
{"concept_id": "C2755858", "aliases": [], "types": ["T043"], "canonical_name": "hypodermal cell division"}
{"concept_id": "C2755859", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hypodermal cell division"}
{"concept_id": "C2755860", "aliases": [], "types": ["T043"], "canonical_name": "regulation of budding cell apical bud growth", "definition": "Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding. [GOC:dph, GOC:jp, GOC:tb, PMID:17417630]"}
{"concept_id": "C2755861", "aliases": [], "types": ["T043"], "canonical_name": "macrophage derived foam cell differentiation", "definition": "The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C2755862", "aliases": [], "types": ["T043"], "canonical_name": "regulation of macrophage derived foam cell differentiation", "definition": "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755863", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of macrophage derived foam cell differentiation", "definition": "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:dph, GOC:tb]"}
{"concept_id": "C2755864", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of macrophage derived foam cell differentiation", "definition": "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755865", "aliases": ["conezyme A pyrophosphatase activity"], "types": ["T044"], "canonical_name": "CoA pyrophosphatase activity", "definition": "Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine. [GOC:tb, PMID:10922370, PMID:16185196]"}
{"concept_id": "C2755866", "aliases": [], "types": ["T043"], "canonical_name": "regulation of meiotic joint molecule formation", "definition": "Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755867", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of meiotic joint molecule formation", "definition": "Any process that decreases the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755868", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell cycle process", "definition": "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755869", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of intestinal phytosterol absorption", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755870", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of endopeptidase activity", "definition": "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755871", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of endopeptidase activity", "definition": "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755872", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of peptidase activity", "definition": "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755876", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of calcidiol 1-monooxygenase activity", "definition": "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755877", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of vitamin D biosynthetic process", "definition": "Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755878", "aliases": [], "types": ["T044"], "canonical_name": "regulation of amino acid import"}
{"concept_id": "C2755879", "aliases": [], "types": ["T043"], "canonical_name": "regulation of metal ion transport", "definition": "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755880", "aliases": [], "types": ["T043"], "canonical_name": "magnesium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755881", "aliases": [], "types": ["T043"], "canonical_name": "cellular magnesium ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755882", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glucan biosynthetic process", "definition": "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755884", "aliases": [], "types": ["T045"], "canonical_name": "regulation of chromatin silencing by small RNA"}
{"concept_id": "C2755885", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic sister chromatid separation", "definition": "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755886", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phosphate transport", "definition": "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755887", "aliases": [], "types": ["T044"], "canonical_name": "regulation of polyamine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755888", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microtubule nucleation", "definition": "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755889", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion", "definition": "Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755890", "aliases": ["microtubule-based transport"], "types": ["T043"], "canonical_name": "microtubule-based transport", "definition": "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. [GOC:cjm, ISBN:0815316194]"}
{"concept_id": "C2755891", "aliases": ["positive regulation of mitotic entry"], "types": ["T043"], "canonical_name": "positive regulation of G2/M transition of mitotic cell cycle", "definition": "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]"}
{"concept_id": "C2755892", "aliases": ["negative regulation of mitotic entry"], "types": ["T043"], "canonical_name": "negative regulation of G2/M transition of mitotic cell cycle", "definition": "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C2755893", "aliases": ["positive regulation of division septum formation", "positive regulation of division septum formation involved in cell cycle cytokinesis", "upregulation of mitotic division septum assembly"], "types": ["T043"], "canonical_name": "positive regulation of division septum assembly", "definition": "Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806]"}
{"concept_id": "C2755894", "aliases": ["negative regulation of division septum formation"], "types": ["T043"], "canonical_name": "negative regulation of division septum assembly", "definition": "Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806]"}
{"concept_id": "C2755895", "aliases": ["regulation of neurite formation", "regulation of neurite biosynthesis", "regulation of neurite growth", "regulation of neurite development"], "types": ["T043"], "canonical_name": "regulation of neuron projection development", "definition": "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]"}
{"concept_id": "C2755896", "aliases": ["positive regulation of neurite formation", "positive regulation of neurite biosynthesis", "positive regulation of neurite development", "positive regulation of neurite growth"], "types": ["T043"], "canonical_name": "positive regulation of neuron projection development", "definition": "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]"}
{"concept_id": "C2755897", "aliases": ["negative regulation of neurite formation", "negative regulation of neurite biosynthesis", "negative regulation of neurite growth", "negative regulation of neurite development"], "types": ["T043"], "canonical_name": "negative regulation of neuron projection development", "definition": "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]"}
{"concept_id": "C2755899", "aliases": [], "types": ["T044"], "canonical_name": "regulation of vitamin D 24-hydroxylase activity", "definition": "Any process that modulates the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755900", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of vitamin D 24-hydroxylase activity", "definition": "Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755901", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cell wall macromolecule metabolic process", "definition": "Any process that modulates the rate, frequency or extent of cell wall macromolecule metabolism. Cell wall macromolecule metabolic processes are the chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755902", "aliases": [], "types": ["T040"], "canonical_name": "regulation of high-density lipoprotein particle clearance", "definition": "Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755903", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of high-density lipoprotein particle clearance", "definition": "Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755904", "aliases": [], "types": ["T040"], "canonical_name": "regulation of lipoprotein particle clearance", "definition": "Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755905", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of lipoprotein particle clearance", "definition": "Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755906", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of lipoprotein particle clearance", "definition": "Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755907", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of high-density lipoprotein particle clearance", "definition": "Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755908", "aliases": [], "types": ["T043"], "canonical_name": "regulation of low-density lipoprotein particle clearance", "definition": "Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755909", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of low-density lipoprotein particle clearance", "definition": "Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755910", "aliases": [], "types": ["T043"], "canonical_name": "regulation of SMAD protein complex assembly", "definition": "Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755911", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of SMAD protein complex assembly", "definition": "Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755912", "aliases": [], "types": ["T043"], "canonical_name": "ubiquitin homeostasis"}
{"concept_id": "C2755914", "aliases": [], "types": ["T044"], "canonical_name": "free ubiquitin chain polymerization", "definition": "The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755915", "aliases": [], "types": ["T044"], "canonical_name": "free ubiquitin chain depolymerization", "definition": "The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755916", "aliases": ["response to auditory stimulus", "response to sound stimulus"], "types": ["T040"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. [GOC:BHF, GOC:dph, GOC:sl, GOC:tb]", "canonical_name": "response to sound"}
{"concept_id": "C2755917", "aliases": ["APC binding"], "types": ["T044"], "canonical_name": "anaphase-promoting complex binding", "definition": "Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755918", "aliases": ["eIF2 alpha phosphorylation in response to stress", "regulation of translational initiation by eIF2 alpha phosphorylation in response to stress"], "types": ["T044"], "canonical_name": "regulation of translational initiation by eIF2 alpha phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha. [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb]"}
{"concept_id": "C2755919", "aliases": [], "types": ["T044"], "canonical_name": "regulation of eIF2 alpha phosphorylation by heme", "definition": "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C2755920", "aliases": [], "types": ["T045"], "canonical_name": "replication fork arrest at mating type locus", "definition": "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus. [GOC:dph, GOC:tb]"}
{"concept_id": "C2755921", "aliases": ["establishment of endothelial blood/brain barrier", "establishment of endothelial BBB"], "types": ["T043"], "canonical_name": "establishment of endothelial blood-brain barrier", "definition": "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. [GOC:aruk, GOC:dgh, GOC:dph, GOC:sart, PMID:20080302, PMID:30280653]"}
{"concept_id": "C2755922", "aliases": [], "types": ["T042"], "canonical_name": "striated muscle tissue development", "definition": "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. [CL:0000737, GOC:dph, GOC:mtg_muscle]"}
{"concept_id": "C2755923", "aliases": [], "types": ["T039"], "canonical_name": "cardiac muscle hypertrophy in response to stress", "definition": "The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]"}
{"concept_id": "C2755925", "aliases": ["haem lyase disulphide oxidoreductase activity"], "types": ["T044"], "canonical_name": "heme lyase disulfide oxidoreductase activity"}
{"concept_id": "C2755926", "aliases": [], "types": ["T044"], "canonical_name": "drug transmembrane transporter activity"}
{"concept_id": "C2755929", "aliases": [], "types": ["T044"], "canonical_name": "secondary active cyanate transmembrane transporter activity", "definition": "Enables the transfer of cyanate from one side of a membrane to the other. [TC:2.A.1.17.1]"}
{"concept_id": "C2755930", "aliases": ["protein secretion by the general secretory pathway"], "types": ["T044"], "canonical_name": "protein secretion by the general secretion pathway"}
{"concept_id": "C2755931", "aliases": [], "types": ["T042"], "canonical_name": "regulation of striated muscle tissue development", "definition": "Any process that modulates the frequency, rate or extent of striated muscle development. [GOC:go_curators]"}
{"concept_id": "C2755932", "aliases": ["cyclin-dependent protein kinase 5 holoenzyme complex location"], "types": ["T026"], "canonical_name": "cyclin-dependent protein kinase 5 holoenzyme complex"}
{"concept_id": "C2755933", "aliases": ["male courtship behaviour, orientation"], "types": ["T054"], "canonical_name": "male courtship behavior, orientation"}
{"concept_id": "C2755936", "aliases": ["L-vinylglycine deaminase activity"], "types": ["T044"], "canonical_name": "L-VG deaminase activity"}
{"concept_id": "C2755937", "aliases": ["negative regulation of RNA polymerase II transcriptional preinitiation complex assembly", "downregulation of RNA polymerase II transcriptional preinitiation complex assembly", "inhibition of RNA polymerase II transcriptional preinitiation complex assembly", "down-regulation of RNA polymerase II transcriptional preinitiation complex assembly", "negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly", "negative regulation of RNA polymerase II transcriptional preinitiation complex formation", "negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis", "down regulation of RNA polymerase II transcriptional preinitiation complex assembly"], "types": ["T045"], "canonical_name": "negative regulation of RNA polymerase II transcription preinitiation complex assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. [GOC:go_curators]"}
{"concept_id": "C2755938", "aliases": [], "types": ["T045"], "canonical_name": "poly(C) binding"}
{"concept_id": "C2755939", "aliases": [], "types": ["T044"], "canonical_name": "chiral amino acid racemization", "definition": "The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid. [GOC:jsg, ISBN:0198506732]"}
{"concept_id": "C2755940", "aliases": ["coenzyme F420-independent methylene-H4MPT dehydrogenase activity", "F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity", "F420-independent methylene-H4MPT dehydrogenase activity", "coenzyme F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity"], "types": ["T044"], "canonical_name": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity", "definition": "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin. [UM-BBD_reactionID:r0353]"}
{"concept_id": "C2755941", "aliases": [], "types": ["T044"], "canonical_name": "atrazine N-dealkylase activity", "definition": "Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O. [MetaCyc:R461-RXN, UM-BBD_reactionID:r0127]"}
{"concept_id": "C2755942", "aliases": [], "types": ["T044"], "canonical_name": "trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity", "definition": "Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde. [UM-BBD_reactionID:r0484]"}
{"concept_id": "C2755943", "aliases": [], "types": ["T040"], "canonical_name": "fruiting body formation involved in asexual reproduction"}
{"concept_id": "C2755944", "aliases": [], "types": ["T040"], "canonical_name": "fruiting body formation involved in sexual reproduction"}
{"concept_id": "C2755945", "aliases": ["contractile ring assembly", "cytokinesis, actomyosin contractile ring assembly", "cytokinesis, actomyosin contractile ring formation"], "types": ["T043"], "canonical_name": "actomyosin contractile ring assembly", "definition": "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis. [GOC:clt, GOC:dph, GOC:tb]"}
{"concept_id": "C2755946", "aliases": [], "types": ["T045"], "canonical_name": "tRNA exon ligation", "definition": "An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed. [GOC:krc]"}
{"concept_id": "C2755947", "aliases": [], "types": ["T045"], "canonical_name": "tRNA exon ligation utilizing ATP as source of linkage phosphate", "definition": "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species. [GOC:krc, PMID:17786051]"}
{"concept_id": "C2755948", "aliases": [], "types": ["T045"], "canonical_name": "tRNA exon ligation utilizing GTP as source of linkage phosphate", "definition": "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process. [GOC:krc, PMID:18217203, PMID:9299409]"}
{"concept_id": "C2755949", "aliases": [], "types": ["T045"], "canonical_name": "tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate", "definition": "A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans. [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409]"}
{"concept_id": "C2755950", "aliases": [], "types": ["T045"], "canonical_name": "transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery", "definition": "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript. [GOC:krc, PMID:18614049]"}
{"concept_id": "C2755951", "aliases": ["posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery"], "types": ["T045"], "canonical_name": "post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery", "definition": "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed. [GOC:krc, PMID:17373856, PMID:18614049]"}
{"concept_id": "C2755952", "aliases": ["NTC", "Prp19 complex location"], "types": ["T026"], "canonical_name": "Prp19 complex", "definition": "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. [GOC:krc, PMID:16540691, PMID:19239890]"}
{"concept_id": "C2755953", "aliases": ["nineteen complex location"], "types": ["T026"], "canonical_name": "nineteen complex"}
{"concept_id": "C2755954", "aliases": ["Prp19/CDC5 complex location"], "types": ["T026"], "canonical_name": "Prp19/CDC5 complex"}
{"concept_id": "C2755955", "aliases": [], "types": ["T044"], "canonical_name": "nonribosomal peptide synthetase"}
{"concept_id": "C2755958", "aliases": [], "types": ["T044"], "canonical_name": "threonine catabolic process to glycine"}
{"concept_id": "C2755959", "aliases": [], "types": ["T043"], "canonical_name": "cell-matrix adhesion involved in tangential migration using cell-cell interactions", "definition": "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex. [GO_REF:0000021, GOC:ascb_2009, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695]"}
{"concept_id": "C2755960", "aliases": ["neural plate axis determination"], "types": ["T040"], "canonical_name": "neural plate axis specification", "definition": "The pattern specification process in which the axes of the nervous system are established. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C2755961", "aliases": ["neural plate anterior/posterior pattern formation"], "types": ["T042"], "canonical_name": "neural plate anterior/posterior regionalization", "definition": "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C2755962", "aliases": [], "types": ["T040"], "canonical_name": "neural cell differentiation"}
{"concept_id": "C2755963", "aliases": ["negative adaptation of signalling pathway", "negative adaptation of signal transduction pathway"], "types": ["T044"], "canonical_name": "negative adaptation of signaling pathway", "definition": "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. [GOC:isa_complete]"}
{"concept_id": "C2755964", "aliases": [], "types": ["T044"], "canonical_name": "active ion transmembrane transporter activity", "definition": "Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C2755974", "aliases": [], "types": ["T043"], "canonical_name": "signal transmission via intracellular cascade"}
{"concept_id": "C2755980", "aliases": ["regulation of gene expression as a consequence of signal transmission"], "types": ["T045"], "canonical_name": "signal transduction involved in regulation of gene expression", "definition": "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. [GOC:mtg_signal]"}
{"concept_id": "C2755982", "aliases": [], "types": ["T039"], "canonical_name": "termination of signal transduction", "definition": "The signaling process in which signal transduction is brought to an end rather than being reversibly modulated. [GOC:mtg_signal]"}
{"concept_id": "C2755983", "aliases": [], "types": ["T044"], "canonical_name": "termination of T cell signal transduction", "definition": "The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated. [GOC:mtg_signal]"}
{"concept_id": "C2755984", "aliases": [], "types": ["T044"], "canonical_name": "MHC protein complex binding", "definition": "Binding to a major histocompatibility complex. [GOC:mtg_signal, GOC:vw]"}
{"concept_id": "C2755985", "aliases": [], "types": ["T044"], "canonical_name": "MHC class I protein complex binding", "definition": "Binding to a class I major histocompatibility complex. [GOC:mtg_signal, GOC:vw]"}
{"concept_id": "C2755986", "aliases": [], "types": ["T044"], "canonical_name": "MHC class Ib protein complex binding", "definition": "Binding to a class Ib major histocompatibility complex. [GOC:mtg_signal, GOC:vw]"}
{"concept_id": "C2755987", "aliases": [], "types": ["T044"], "canonical_name": "MHC class II protein complex binding", "definition": "Binding to a class II major histocompatibility complex. [GOC:mtg_signal, GOC:vw]"}
{"concept_id": "C2755988", "aliases": [], "types": ["T044"], "canonical_name": "MHC class I protein binding, via antigen binding groove", "definition": "Binding to a major histocompatibility complex class I molecules via the antigen binding groove. [GOC:mtg_signal, GOC:vw]"}
{"concept_id": "C2755989", "aliases": [], "types": ["T044"], "canonical_name": "MHC class I protein binding, via lateral surface", "definition": "Binding to a major histocompatibility complex class I molecules via the lateral surface. [GOC:mtg_signal, GOC:vw]"}
{"concept_id": "C2755990", "aliases": [], "types": ["T044"], "canonical_name": "MHC class Ib protein binding", "definition": "Binding to a major histocompatibility complex class Ib molecules. [GOC:mtg_signal, GOC:vw]"}
{"concept_id": "C2755991", "aliases": [], "types": ["T044"], "canonical_name": "MHC class Ib protein binding, via antigen binding groove", "definition": "Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove. [GOC:mtg_signal, GOC:vw]"}
{"concept_id": "C2755992", "aliases": [], "types": ["T044"], "canonical_name": "MHC class Ib protein binding, via lateral surface", "definition": "Binding to a major histocompatibility complex class Ib molecules via the lateral surface. [GOC:mtg_signal, GOC:vw]"}
{"concept_id": "C2755994", "aliases": ["intracellular signaling pathway"], "types": ["T043"], "canonical_name": "intracellular signal transduction pathway"}
{"concept_id": "C2755995", "aliases": ["CD40 signalling pathway"], "types": ["T039"], "canonical_name": "CD40 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mtg_signal, GOC:signaling, PMID:11348017]"}
{"concept_id": "C2756001", "aliases": [], "types": ["T043"], "canonical_name": "neuronal signal transduction", "definition": "The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular. [GOC:mtg_signal]"}
{"concept_id": "C2756011", "aliases": ["regulation of signalling process", "regulation of signaling process"], "types": ["T038"], "canonical_name": "regulation of signaling", "definition": "Any process that modulates the frequency, rate or extent of a signaling process. [GOC:mtg_signal]"}
{"concept_id": "C2756015", "aliases": ["positive regulation of signalling process", "positive regulation of signaling process"], "types": ["T038"], "canonical_name": "positive regulation of signaling", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. [GOC:mtg_signal]"}
{"concept_id": "C2756016", "aliases": ["negative regulation of signalling process"], "types": ["T038"], "canonical_name": "negative regulation of signaling process"}
{"concept_id": "C2756017", "aliases": ["adaptation of signalling pathway"], "types": ["T044"], "canonical_name": "adaptation of signaling pathway", "definition": "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. [GOC:mtg_signal]"}
{"concept_id": "C2756018", "aliases": ["positive adaptation of signalling pathway"], "types": ["T044"], "canonical_name": "positive adaptation of signaling pathway", "definition": "The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. [GOC:mtg_signal]"}
{"concept_id": "C2756020", "aliases": ["signal secretion"], "types": ["T039"], "canonical_name": "signal release", "definition": "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. [GOC:mtg_signal]"}
{"concept_id": "C2756028", "aliases": [], "types": ["T044"], "canonical_name": "nitric oxide transmembrane transporter activity", "definition": "Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C2756030", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle thin filament assembly", "definition": "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle. [GOC:ef, GOC:mah, GOC:mtg_muscle]"}
{"concept_id": "C2756031", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle myosin thick filament assembly", "definition": "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle. [GOC:ef, GOC:mah, GOC:mtg_muscle]"}
{"concept_id": "C2756032", "aliases": [], "types": ["T043"], "canonical_name": "intestinal cholesterol absorption", "definition": "Uptake of cholesterol into the blood by absorption from the small intestine. [GOC:mah]"}
{"concept_id": "C2756033", "aliases": [], "types": ["T044"], "canonical_name": "regulation of intestinal cholesterol absorption", "definition": "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption. [GOC:mah, PMID:11099417]"}
{"concept_id": "C2756034", "aliases": ["p53 signaling pathway"], "types": ["T044"], "canonical_name": "TP53 signaling pathway"}
{"concept_id": "C2756035", "aliases": ["calcitriol 24-hydroxylase activity", "1,25-(OH)2D3 24-hydroxylase activity"], "types": ["T044"], "canonical_name": "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity", "definition": "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol). [PMID:8506296]"}
{"concept_id": "C2756036", "aliases": [], "types": ["T045"], "canonical_name": "aging-dependent sterility"}
{"concept_id": "C2756037", "aliases": [], "types": ["T045"], "canonical_name": "chromatin silencing at HML and HMR"}
{"concept_id": "C2756040", "aliases": [], "types": ["T043"], "canonical_name": "germline ring canal formation", "definition": "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts. [ISBN:0879694238]"}
{"concept_id": "C2756041", "aliases": [], "types": ["T043"], "canonical_name": "male germline ring canal formation", "definition": "Formation of the intercellular bridges that connect the germ-line cells of a male cyst. [ISBN:0879694238]"}
{"concept_id": "C2756042", "aliases": [], "types": ["T043"], "canonical_name": "spermatocyte ring canal formation"}
{"concept_id": "C2756043", "aliases": ["NADH dehydrogenase complex location (quinone)"], "types": ["T026"], "canonical_name": "NADH dehydrogenase complex (quinone)"}
{"concept_id": "C2756044", "aliases": [], "types": ["T043"], "canonical_name": "linear element assembly", "definition": "The cell cycle process in which linear elements are assembled in association with fission yeast chromosomes during meiotic prophase. Linear element assembly begins with LinE complex formation and ends when LinE complexes are associated with chromatin in structures visible as nuclear foci. A linear element is a proteinaceous scaffold related to the synaptonemal complex. [GOC:jb, GOC:mah, PMID:30640914]"}
{"concept_id": "C2756046", "aliases": [], "types": ["T042"], "canonical_name": "neuron projection regeneration", "definition": "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. [GOC:dgh, GOC:dph, GOC:tb]"}
{"concept_id": "C2756047", "aliases": [], "types": ["T043"], "canonical_name": "developmental induction", "definition": "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535]"}
{"concept_id": "C2756048", "aliases": ["stalk development"], "types": ["T040"], "canonical_name": "stalk formation"}
{"concept_id": "C2756049", "aliases": [], "types": ["T043"], "canonical_name": "lateral pseudopodium assembly", "definition": "The extension of a pseudopodium from the lateral area of a cell. [GOC:dph, GOC:mah, GOC:pg, GOC:tb]"}
{"concept_id": "C2756052", "aliases": [], "types": ["T040"], "canonical_name": "fruiting body morphogenesis"}
{"concept_id": "C2756054", "aliases": ["TIMELESS-TIPIN complex location"], "types": ["T026"], "canonical_name": "TIMELESS-TIPIN complex"}
{"concept_id": "C2756055", "aliases": [], "types": ["T043"], "canonical_name": "forespore formation"}
{"concept_id": "C2756058", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell projection organization"}
{"concept_id": "C2756060", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cell projection organization"}
{"concept_id": "C2756062", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-asparagine deamination", "definition": "The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein. [GOC:bf, GOC:mah]"}
{"concept_id": "C2756064", "aliases": [], "types": ["T043"], "canonical_name": "chitin- and beta-glucan-containing cell wall organisation"}
{"concept_id": "C2756065", "aliases": ["Sec complex location"], "types": ["T026"], "canonical_name": "Sec complex"}
{"concept_id": "C2756066", "aliases": ["contractile ring maintenance involved in cell cycle cytokinesis", "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle"], "types": ["T043"], "canonical_name": "actomyosin contractile ring maintenance", "definition": "The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle. [GOC:dph, GOC:mah, GOC:tb, GOC:vw]"}
{"concept_id": "C2756068", "aliases": [], "types": ["T045"], "canonical_name": "telomere end processing"}
{"concept_id": "C2756069", "aliases": ["regulation of actomyosin contractile ring constriction", "regulation of contractile ring contraction involved in cell cycle cytokinesis", "regulation of contractile ring contraction involved in cytokinesis during cell cycle"], "types": ["T043"], "canonical_name": "regulation of actomyosin contractile ring contraction", "definition": "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C2756072", "aliases": [], "types": ["T043"], "canonical_name": "medial membrane band assembly", "definition": "The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring. [PMID:15517003]"}
{"concept_id": "C2756073", "aliases": [], "types": ["T040"], "canonical_name": "fruiting body development involved in sexual reproduction"}
{"concept_id": "C2756972", "aliases": ["up-regulation of focal adhesion formation", "up regulation of focal adhesion formation", "upregulation of focal adhesion formation"], "types": ["T043"], "canonical_name": "positive regulation of focal adhesion assembly", "definition": "Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. [GOC:ai]"}
{"concept_id": "C2756973", "aliases": ["downregulation of focal adhesion formation", "down regulation of focal adhesion formation", "down-regulation of focal adhesion formation"], "types": ["T043"], "canonical_name": "negative regulation of focal adhesion assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. [GOC:ai]"}
{"concept_id": "C2757054", "aliases": ["epithelial-mesenchymal signalling involved in prostate gland development"], "types": ["T043"], "canonical_name": "epithelial-mesenchymal signaling involved in prostate gland development", "definition": "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time. [GOC:dph]"}
{"concept_id": "C2825035", "aliases": ["down-regulation of ATP:ADP antiporter activity", "down regulation of ATP:ADP antiporter activity", "downregulation of ATP:ADP antiporter activity"], "types": ["T044"], "canonical_name": "negative regulation of ATP:ADP antiporter activity", "definition": "Any process that stops or reduces the activity of an ATP:ADP antiporter. [GOC:BHF, GOC:mah]"}
{"concept_id": "C2825037", "aliases": ["sperm individualization complex location"], "types": ["T026"], "canonical_name": "sperm individualization complex", "definition": "A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst. [GOC:sart, PMID:10588662, PMID:9550716]"}
{"concept_id": "C2825038", "aliases": ["microprocessor complex location"], "types": ["T026"], "canonical_name": "microprocessor complex", "definition": "A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs. [PMID:16963499, PMID:17159994]"}
{"concept_id": "C2825039", "aliases": ["purine deoxyribosyltransferase activity", "PTD"], "types": ["T044"], "definition": "Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor. [GOC:jl, PMID:11836245]", "canonical_name": "purine 2'-deoxyribosyltransferase activity"}
{"concept_id": "C2825057", "aliases": ["down regulation of calcineurin-NFAT signaling cascade", "negative regulation of calcineurin-NFAT signaling pathway", "negative regulation of calcineurin-NFAT signalling cascade", "downregulation of calcineurin-NFAT signaling cascade", "down-regulation of calcineurin-NFAT signaling cascade"], "types": ["T044"], "canonical_name": "negative regulation of calcineurin-NFAT signaling cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. [GOC:mah]"}
{"concept_id": "C2825062", "aliases": ["vitamin D2 25-hydroxylase activity"], "types": ["T044"], "canonical_name": "ergocalciferol 25-hydroxylase activity"}
{"concept_id": "C2825088", "aliases": ["vitamin D2 metabolism", "calciferol metabolic process", "ergocalciferol metabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol. [GOC:BHF, GOC:mah]", "canonical_name": "vitamin D2 metabolic process"}
{"concept_id": "C2825089", "aliases": ["immunoglobulin light chain V-J recombination", "immunoglobulin V(D)J joining", "immunoglobulin V(D)J recombination"], "types": ["T045"], "definition": "The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). [GOC:add, ISBN:0781735149]", "canonical_name": "immunoglobulin V-J joining"}
{"concept_id": "C2825109", "aliases": ["stimulation of vitamin D receptor signaling pathway"], "types": ["T044"], "canonical_name": "activation of vitamin D receptor signaling pathway"}
{"concept_id": "C2828349", "aliases": [], "types": ["T042"], "canonical_name": "metanephric glomerulus vasculature development", "definition": "The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C2828350", "aliases": ["macropinocytic cup"], "types": ["T026"], "definition": "A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin. [PMID:12538772, PMID:16968738, PMID:9044041]", "canonical_name": "crown"}
{"concept_id": "C2828354", "aliases": ["organelle membrane contact site"], "types": ["T026"], "definition": "A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. [GOC:jl, PMID:16806880]", "canonical_name": "MCS"}
{"concept_id": "C2828355", "aliases": [], "types": ["T026"], "canonical_name": "IgG2c"}
{"concept_id": "C2828356", "aliases": [], "types": ["T026"], "canonical_name": "IgG3"}
{"concept_id": "C2828357", "aliases": [], "types": ["T026"], "canonical_name": "IgG4"}
{"concept_id": "C2828364", "aliases": [], "types": ["T040"], "canonical_name": "single fertilization", "definition": "The union of male and female gametes to form a zygote. [GOC:ems, GOC:mtg_sensu]"}
{"concept_id": "C2828365", "aliases": [], "types": ["T042"], "canonical_name": "pattern formation"}
{"concept_id": "C2828390", "aliases": ["interleukin-35 complex location", "IL-35 complex location", "interleukin-35 complex", "IL12A", "IL-35 complex"], "types": ["T026"], "definition": "A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space. [GOC:add, PMID:19161428, PMID:19161429]", "canonical_name": "p35"}
{"concept_id": "C2830228", "aliases": ["glutamic acid tRNA"], "types": ["T045"], "canonical_name": "glutamic acid tRNA"}
{"concept_id": "C2917212", "aliases": ["down regulation of coagulation", "negative regulation of clotting", "negative regulation of coagulation", "downregulation of coagulation"], "types": ["T039"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. [GOC:ai]", "canonical_name": "down-regulation of coagulation"}
{"concept_id": "C2919059", "aliases": ["ESCRT complex", "ESCRT complex location", "endosomal sorting complex required for transport"], "types": ["T026"], "definition": "An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes. [PMID:16689637, VZ:1536]", "canonical_name": "endosomal sorting complex location required for transport"}
{"concept_id": "C2936195", "aliases": [], "types": ["T038"], "definition": "Process by which micro-organisms adapt quickly to a preferred rapidly-metabolizable intermediate through the inhibition or repression of genes related to CATABOLISM of less preferred source(s).", "canonical_name": "catabolite repression"}
{"concept_id": "C2945689", "aliases": ["neuropilin binding", "neuropilin-binding"], "types": ["T044"], "definition": "Binding to a member of the neuropilin family. [GOC:bf, PMID:23871893]", "canonical_name": "Nrp binding"}
{"concept_id": "C2980031", "aliases": ["desensitization to pheromone during pheromone-induced unidirectional conjugation", "negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation"], "types": ["T043"], "canonical_name": "negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation", "definition": "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses. [GOC:clt]"}
{"concept_id": "C2980050", "aliases": [], "types": ["T043"], "definition": "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. [CL:0000034, GOC:isa_complete]", "canonical_name": "stem cell development"}
{"concept_id": "C2980055", "aliases": ["mRNA export from cell nucleus during heat stress", "mRNA export from nucleus during heat stress"], "types": ["T043"], "canonical_name": "mRNA export from nucleus in response to heat stress", "definition": "The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export. [GOC:mah, GOC:vw]"}
{"concept_id": "C2980064", "aliases": ["adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion", "desensitization to pheromone during conjugation with cellular fusion"], "types": ["T043"], "canonical_name": "adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion", "definition": "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae. [GOC:clt]"}
{"concept_id": "C2980067", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C2980085", "aliases": ["negative regulation of sequence-specific DNA binding transcription factor activity", "negative regulation of DNA binding transcription factor activity", "downregulation of transcription factor activity", "down regulation of transcription factor activity", "down-regulation of transcription factor activity"], "types": ["T045"], "canonical_name": "negative regulation of DNA-binding transcription factor activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:jl]"}
{"concept_id": "C2980086", "aliases": ["up-regulation of transcription factor activity", "positive regulation of DNA binding transcription factor activity", "upregulation of transcription factor activity", "positive regulation of sequence-specific DNA binding transcription factor activity", "up regulation of transcription factor activity"], "types": ["T045"], "canonical_name": "positive regulation of DNA-binding transcription factor activity", "definition": "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]"}
{"concept_id": "C2980088", "aliases": ["protein carboxyl methyltransferase activity"], "types": ["T044"], "canonical_name": "protein carboxyl O-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to a carboxyl group on a protein. [GOC:ai]"}
{"concept_id": "C2980092", "aliases": ["down regulation of stress-activated protein kinase signaling pathway", "downregulation of stress-activated protein kinase signaling pathway", "negative regulation of SAPK signaling pathway", "down-regulation of stress-activated protein kinase signaling pathway", "negative regulation of stress-activated protein kinase signaling pathway", "negative regulation of stress-activated protein kinase signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of stress-activated protein kinase signaling cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. [GOC:mah]"}
{"concept_id": "C2980093", "aliases": ["up-regulation of stress-activated protein kinase signaling pathway", "up regulation of stress-activated protein kinase signaling pathway", "positive regulation of SAPK signaling pathway", "positive regulation of stress-activated protein kinase signalling pathway", "upregulation of stress-activated protein kinase signaling pathway", "positive regulation of stress-activated protein kinase signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of stress-activated protein kinase signaling cascade", "definition": "Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. [GOC:mah]"}
{"concept_id": "C2984233", "aliases": ["alpha-linolenic acid metabolism", "ALA metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. [PMID:15538555]", "canonical_name": "alpha-linolenic acid metabolic process"}
{"concept_id": "C2984256", "aliases": ["neurotrophin signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, Wikipedia:Neurotrophin]", "canonical_name": "neurotrophin receptor signaling pathway"}
{"concept_id": "C2984268", "aliases": ["axon guidance", "axon pathfinding"], "types": ["T043"], "definition": "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]", "canonical_name": "axon growth cone guidance"}
{"concept_id": "C2984295", "aliases": ["homologous recombination", "interchromosomal DNA recombination"], "types": ["T169"], "definition": "A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules. [GOC:mah, PMID:11139492, PMID:17304215]", "canonical_name": "interstrand DNA recombination"}
{"concept_id": "C2984315", "aliases": [], "types": ["T044"], "canonical_name": "NOD-like receptor signaling pathway"}
{"concept_id": "C2984318", "aliases": ["ABC-type transmembrane transporter activity", "ATP-binding cassette transporter", "ABC-type efflux porter activity", "ABC-type efflux permease activity", "ATP binding cassette transporter", "ABC-type uptake permease activity", "ABC transporter", "ATP-binding cassette (ABC) transporter activity"], "types": ["T169"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:jl]", "canonical_name": "ABC-type transporter activity"}
{"concept_id": "C2984323", "aliases": ["ErbB signaling", "EGF receptor family signaling pathway", "ERBB signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:16460914, Wikipedia:ErbB]", "canonical_name": "ERBB signalling pathway"}
{"concept_id": "C2984366", "aliases": [], "types": ["T043"], "canonical_name": "ceramide signaling pathway"}
{"concept_id": "C2984395", "aliases": ["ERBB2-ERBB3 signalling pathway", "ERBB2-ERBB3 signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission. [GOC:signaling, PMID:16460914, Reactome:R-HSA-1963589]", "canonical_name": "HER2-HER3 signaling pathway"}
{"concept_id": "C2984396", "aliases": ["receptor tyrosine-protein kinase erbB-4 signaling pathway", "ERBB4 signalling pathway", "HER4 signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:16460914, Reactome:R-HSA-1236394]", "canonical_name": "ERBB4 signaling pathway"}
{"concept_id": "C2984448", "aliases": [], "types": ["T044"], "canonical_name": "PDGFR-alpha signaling pathway"}
{"concept_id": "C2984449", "aliases": ["PDGF receptor-beta signaling pathway", "betaPDGF receptor signaling pathway", "platelet-derived growth factor receptor-beta signaling pathway", "PDGFR-beta signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961]", "canonical_name": "platelet-derived growth factor receptor-beta signalling pathway"}
{"concept_id": "C2984460", "aliases": [], "types": ["T044"], "canonical_name": "regulation of androgen receptor activity"}
{"concept_id": "C2984468", "aliases": ["S1P receptor signaling pathway", "S1P-activated GPCR signaling pathway", "S1P-stimulated signal transduction pathway", "sphingosine-1-phosphate receptor signaling pathway", "S1P-activated G-protein coupled receptor signaling pathway"], "types": ["T044"], "definition": "A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186, Reactome:R-HSA-419428]", "canonical_name": "S1P signaling pathway"}
{"concept_id": "C2984480", "aliases": ["stem cell factor signaling pathway", "SCF signaling pathway", "Kit signaling pathway", "stem cell factor receptor signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell. [GOC:nhn, GOC:signaling, PMID:16129412]", "canonical_name": "Kit signalling pathway"}
{"concept_id": "C2984496", "aliases": ["FLT1 signaling pathway", "vascular endothelial growth factor receptor-1 signaling pathway", "VEGFR1 signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-1 (VEGFR-1) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:uh, Wikipedia:FLT1, Wikipedia:VEGF_receptors]", "canonical_name": "VEGFR-1 signaling pathway"}
{"concept_id": "C2984497", "aliases": ["FLT4 signaling pathway", "VEGFR-3 signaling pathway", "vascular endothelial growth factor receptor-3 signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-3 (VEGFR-3) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:uh, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3]", "canonical_name": "VEGFR3 signaling pathway"}
{"concept_id": "C3146300", "aliases": ["glycoprotein biosynthetic process", "glycoprotein anabolism", "glycoprotein formation", "glycoprotein biosynthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]", "canonical_name": "glycoprotein synthesis"}
{"concept_id": "C3152111", "aliases": ["dTORC1", "rapamycin and nutrient-sensitive TOR complex location", "TORC 1 complex location", "TORC 1 complex", "nutrient sensitive complex location", "TOR complex location 1", "TOR complex 1", "mTORC1", "nutrient sensitive complex", "TORC1 complex", "rapamycin and nutrient-sensitive TOR complex", "TORC1"], "types": ["T026"], "definition": "A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p. [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]", "canonical_name": "TORC1 complex location"}
{"concept_id": "C3154907", "aliases": [], "types": ["T043"], "canonical_name": "blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "definition": "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis. [GOC:dph, GOC:tb, PMID:16391003]"}
{"concept_id": "C3154908", "aliases": ["purine base binding"], "types": ["T044"], "canonical_name": "purine nucleobase binding", "definition": "Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton. [GOC:hjd]"}
{"concept_id": "C3154909", "aliases": ["pyrimidine base binding"], "types": ["T044"], "canonical_name": "pyrimidine nucleobase binding", "definition": "Binding to a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton. [GOC:hjd]"}
{"concept_id": "C3154912", "aliases": ["high affinity IgA receptor activity"], "types": ["T044"], "canonical_name": "high-affinity IgA receptor activity", "definition": "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:hjd, GOC:signaling]"}
{"concept_id": "C3154913", "aliases": ["low affinity IgA receptor activity"], "types": ["T044"], "canonical_name": "low-affinity IgA receptor activity", "definition": "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:hjd, GOC:signaling]"}
{"concept_id": "C3154914", "aliases": ["high affinity IgM receptor activity"], "types": ["T044"], "canonical_name": "high-affinity IgM receptor activity", "definition": "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:hjd, GOC:signaling]"}
{"concept_id": "C3154915", "aliases": ["low affinity IgM receptor activity"], "types": ["T044"], "canonical_name": "low-affinity IgM receptor activity", "definition": "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:hjd, GOC:signaling]"}
{"concept_id": "C3154916", "aliases": [], "types": ["T043"], "canonical_name": "mammary stem cell proliferation", "definition": "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ. [PMID:15987436]"}
{"concept_id": "C3154917", "aliases": ["protein localisation to paranode region of axon"], "types": ["T043"], "canonical_name": "protein localization to paranode region of axon", "definition": "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon. [PMID:18803321]"}
{"concept_id": "C3154918", "aliases": [], "types": ["T043"], "canonical_name": "male germ cell proliferation", "definition": "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population. [GOC:hjd]"}
{"concept_id": "C3154919", "aliases": [], "types": ["T026"], "canonical_name": "manchette", "definition": "A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments. [GOC:krc, PMID:15018141, PMID:22319670, PMID:24440897, PMID:26792866]"}
{"concept_id": "C3154920", "aliases": ["homodimeric serine palmitoyltransferase complex location"], "types": ["T026"], "canonical_name": "homodimeric serine palmitoyltransferase complex", "definition": "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine. [GOC:hjd]"}
{"concept_id": "C3154921", "aliases": [], "types": ["T043"], "canonical_name": "alpha-beta T cell development"}
{"concept_id": "C3154922", "aliases": [], "types": ["T043"], "canonical_name": "regulation of alpha-beta T cell development"}
{"concept_id": "C3154923", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of alpha-beta T cell development"}
{"concept_id": "C3154924", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of alpha-beta T cell development"}
{"concept_id": "C3154925", "aliases": [], "types": ["T043"], "canonical_name": "borate transport", "definition": "The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals. [PMID:21710975]"}
{"concept_id": "C3154926", "aliases": [], "types": ["T044"], "canonical_name": "borate binding", "definition": "Binding to borate, the anion (BO3)3-. [GOC:curators]"}
{"concept_id": "C3154927", "aliases": [], "types": ["T044"], "canonical_name": "borate transmembrane transporter activity"}
{"concept_id": "C3154928", "aliases": [], "types": ["T044"], "canonical_name": "boron transmembrane transporter activity"}
{"concept_id": "C3154929", "aliases": [], "types": ["T043"], "canonical_name": "muscle fiber maintenance"}
{"concept_id": "C3154930", "aliases": [], "types": ["T043"], "canonical_name": "muscle homeostasis"}
{"concept_id": "C3154932", "aliases": ["virus budding from nuclear membrane during viral capsid re-envelopment"], "types": ["T043"], "canonical_name": "viral budding from nuclear membrane during viral capsid re-envelopment"}
{"concept_id": "C3154936", "aliases": [], "types": ["T043"], "canonical_name": "virus budding from outer nuclear membrane during viral capsid re-envelopment"}
{"concept_id": "C3154937", "aliases": ["virus budding from inner nuclear membrane by viral capsid envelopment"], "types": ["T043"], "canonical_name": "viral budding from inner nuclear membrane", "definition": "The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system into the perinuclear space, thus acquiring a membrane envelope. [ISBN:0072370319]"}
{"concept_id": "C3154938", "aliases": ["virus budding from outer nuclear membrane by viral capsid envelopment"], "types": ["T043"], "canonical_name": "viral budding from outer nuclear membrane", "definition": "The envelopment of a virus, in which the naked capsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope. [ISBN:0072370319]"}
{"concept_id": "C3154941", "aliases": [], "types": ["T044"], "canonical_name": "folic acid-containing compound polyglutamylation"}
{"concept_id": "C3154944", "aliases": [], "types": ["T044"], "canonical_name": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN]"}
{"concept_id": "C3154945", "aliases": [], "types": ["T044"], "canonical_name": "20alpha-hydroxy steroid dehydrogenase activity"}
{"concept_id": "C3154946", "aliases": [], "types": ["T044"], "canonical_name": "pregnan-21-ol dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al. [EC:1.1.1.150, RHEA:11448]"}
{"concept_id": "C3154947", "aliases": [], "types": ["T044"], "canonical_name": "pregnan-21-ol dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al. [EC:1.1.1.151, RHEA:23712]"}
{"concept_id": "C3154948", "aliases": [], "types": ["T044"], "canonical_name": "cholate 12-alpha dehydrogenase activity", "definition": "Catalysis of the reaction: cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH. [EC:1.1.1.176, RHEA:14129]"}
{"concept_id": "C3154949", "aliases": [], "types": ["T044"], "canonical_name": "androsterone dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN]"}
{"concept_id": "C3154950", "aliases": [], "types": ["T044"], "canonical_name": "5alpha-androstane-3beta,17beta-diol dehydrogenase activity", "definition": "Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH. [EC:1.1.1.210, RHEA:16297]"}
{"concept_id": "C3154951", "aliases": [], "types": ["T044"], "canonical_name": "androsterone dehydrogenase (A-specific) activity", "definition": "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. [EC:1.1.1.213, MetaCyc:1.1.1.213-RXN]"}
{"concept_id": "C3154952", "aliases": ["17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity", "testosterone 17-beta-dehydrogenase (NAD+) activity", "testosterone 17beta-dehydrogenase activity", "testosterone 17b-dehydrogenase activity"], "types": ["T044"], "canonical_name": "testosterone dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. [EC:1.1.1.239, MetaCyc:1.1.1.239-RXN]"}
{"concept_id": "C3154953", "aliases": [], "types": ["T044"], "canonical_name": "androstan-3-alpha,17-beta-diol dehydrogenase activity", "definition": "Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN]"}
{"concept_id": "C3154954", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:auxin glucosyltransferase activity"}
{"concept_id": "C3154957", "aliases": ["GTP:GTP guanylyltransferase activity"], "types": ["T044"], "canonical_name": "GTP:GTP guanylyltransferase activity"}
{"concept_id": "C3154958", "aliases": [], "types": ["T044"], "canonical_name": "amino-terminal binding"}
{"concept_id": "C3154959", "aliases": [], "types": ["T044"], "canonical_name": "amino-terminus binding"}
{"concept_id": "C3154961", "aliases": [], "types": ["T044"], "canonical_name": "NH2-terminal binding"}
{"concept_id": "C3154962", "aliases": [], "types": ["T044"], "canonical_name": "NH2-terminus binding"}
{"concept_id": "C3154964", "aliases": [], "types": ["T044"], "canonical_name": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity", "definition": "Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH. [EC:1.1.1.238, RHEA:21424]"}
{"concept_id": "C3154965", "aliases": ["receptor ligand activity", "signaling molecule"], "types": ["T044"], "definition": "The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands). [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt]", "canonical_name": "signaling receptor ligand activity"}
{"concept_id": "C3154966", "aliases": ["downregulation of developmental pigmentation", "down-regulation of developmental pigmentation", "down regulation of developmental pigmentation"], "types": ["T038"], "canonical_name": "negative regulation of developmental pigmentation", "definition": "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. [GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C3154967", "aliases": ["up regulation of developmental pigmentation", "upregulation of developmental pigmentation", "up-regulation of developmental pigmentation"], "types": ["T038"], "canonical_name": "positive regulation of developmental pigmentation", "definition": "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. [GOC:dph, GOC:jid, GOC:tb]"}
{"concept_id": "C3154968", "aliases": [], "types": ["T038"], "canonical_name": "activation of developmental pigmentation"}
{"concept_id": "C3154969", "aliases": [], "types": ["T038"], "canonical_name": "stimulation of developmental pigmentation"}
{"concept_id": "C3154971", "aliases": [], "types": ["T043"], "canonical_name": "nuclear membrane fusion involved in karyogamy", "definition": "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. [GOC:jid]"}
{"concept_id": "C3154972", "aliases": [], "types": ["T044"], "canonical_name": "mucilage biosynthetic process during seed coat development"}
{"concept_id": "C3154973", "aliases": [], "types": ["T044"], "canonical_name": "mucilage metabolic process during seed coat development"}
{"concept_id": "C3154974", "aliases": [], "types": ["T042"], "canonical_name": "embryonic digestive tract development", "definition": "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. [GOC:go_curators]"}
{"concept_id": "C3154976", "aliases": [], "types": ["T044"], "canonical_name": "pigment biosynthetic process involved in pigment granule maturation", "definition": "The chemical reactions and pathways resulting in the formation of a pigment, contributing to the process in which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state. [GOC:jid]"}
{"concept_id": "C3154977", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic dense body"}
{"concept_id": "C3154978", "aliases": [], "types": ["T026"], "canonical_name": "T-bar ribbon"}
{"concept_id": "C3154980", "aliases": [], "types": ["T044"], "canonical_name": "endo-beta-N-acetyl-D-galactosaminidase activity"}
{"concept_id": "C3154981", "aliases": [], "types": ["T044"], "canonical_name": "endo-beta-N-acetylgalactosaminidase"}
{"concept_id": "C3154983", "aliases": [], "types": ["T045"], "canonical_name": "somatic recombination of immunoglobulin genes involved in immune response", "definition": "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3154984", "aliases": [], "types": ["T045"], "canonical_name": "somatic hypermutation of immunoglobulin genes involved in immune response", "definition": "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response. [GOC:add, ISBN:0781735149, PMID:11205333, PMID:14991701]"}
{"concept_id": "C3154985", "aliases": [], "types": ["T045"], "canonical_name": "gene conversion of immunoglobulin genes involved in immune response", "definition": "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response. [GOC:add, PMID:14991701]"}
{"concept_id": "C3154986", "aliases": [], "types": ["T038"], "canonical_name": "somatic diversification of immunoglobulins involved in immune response", "definition": "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. [GOC:add, ISBN:0781735149, PMID:14991701]"}
{"concept_id": "C3154987", "aliases": [], "types": ["T043"], "canonical_name": "leukocyte chemotaxis involved in inflammatory response", "definition": "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3154988", "aliases": [], "types": ["T040"], "canonical_name": "wound healing involved in inflammatory response", "definition": "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response. [GOC:jal, ISBN:0721601871]"}
{"concept_id": "C3154989", "aliases": [], "types": ["T040"], "canonical_name": "inflammatory response wound healing"}
{"concept_id": "C3154990", "aliases": [], "types": ["T038"], "canonical_name": "clearance of damaged tissue involved in inflammatory response wound healing", "definition": "The series of events leading to removal of necrotic debris that contribute to an inflammatory response. [GOC:jal, ISBN:0721601871]"}
{"concept_id": "C3154991", "aliases": [], "types": ["T038"], "canonical_name": "connective tissue replacement involved in inflammatory response wound healing", "definition": "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response. [GOC:jal, ISBN:0721601871]"}
{"concept_id": "C3154992", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell activation within high endothelial venule involved in immune response", "definition": "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3154993", "aliases": [], "types": ["T043"], "canonical_name": "cell activation involved in immune response", "definition": "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C3154994", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell activation involved in immune response", "definition": "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3154995", "aliases": [], "types": ["T043"], "canonical_name": "astrocyte activation involved in immune response", "definition": "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. [GOC:add, PMID:11138785]"}
{"concept_id": "C3154996", "aliases": [], "types": ["T043"], "canonical_name": "follicular dendritic cell activation involved in immune response", "definition": "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. [GOC:add, PMID:15606789]"}
{"concept_id": "C3154997", "aliases": [], "types": ["T043"], "canonical_name": "leukocyte activation involved in inflammatory response", "definition": "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3154998", "aliases": [], "types": ["T043"], "canonical_name": "plasmacytoid dendritic cell activation involved in immune response", "definition": "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. [GOC:add, PMID:15990333, PMID:16174109]"}
{"concept_id": "C3154999", "aliases": [], "types": ["T043"], "canonical_name": "plasmacytoid dendritic cell differentiation involved in immune response", "definition": "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response. [GOC:add, PMID:15990333]"}
{"concept_id": "C3155000", "aliases": [], "types": ["T043"], "canonical_name": "myeloid cell activation involved in immune response", "definition": "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155001", "aliases": [], "types": ["T043"], "canonical_name": "basophil activation involved in immune response", "definition": "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155002", "aliases": [], "types": ["T043"], "canonical_name": "myeloid dendritic cell activation involved in immune response", "definition": "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155003", "aliases": [], "types": ["T043"], "canonical_name": "eosinophil activation involved in immune response", "definition": "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155004", "aliases": [], "types": ["T043"], "canonical_name": "mast cell activation involved in immune response", "definition": "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155005", "aliases": [], "types": ["T043"], "canonical_name": "monocyte activation involved in immune response", "definition": "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149, PMID:16551245]"}
{"concept_id": "C3155006", "aliases": ["macrophage polarization involved in immune response"], "types": ["T043"], "canonical_name": "macrophage activation involved in immune response", "definition": "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155007", "aliases": [], "types": ["T043"], "canonical_name": "microglial cell activation involved in immune response", "definition": "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155008", "aliases": [], "types": ["T043"], "canonical_name": "neutrophil activation involved in immune response", "definition": "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155009", "aliases": [], "types": ["T043"], "canonical_name": "myeloid dendritic cell differentiation involved in immune response", "definition": "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155010", "aliases": [], "types": ["T043"], "canonical_name": "lymphocyte activation involved in immune response", "definition": "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155011", "aliases": [], "types": ["T043"], "canonical_name": "T cell activation involved in immune response", "definition": "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155012", "aliases": [], "types": ["T043"], "canonical_name": "alpha-beta T cell activation involved in immune response", "definition": "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155013", "aliases": [], "types": ["T043"], "canonical_name": "NK T cell activation involved in immune response", "definition": "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. [GOC:add, PMID:15771592]"}
{"concept_id": "C3155014", "aliases": [], "types": ["T043"], "canonical_name": "NK T cell proliferation involved in immune response", "definition": "The expansion of a NK T cell population by cell division as part of an immune response. [GOC:add, PMID:15771592]"}
{"concept_id": "C3155015", "aliases": [], "types": ["T043"], "canonical_name": "gamma-delta T cell activation involved in immune response", "definition": "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. [GOC:add, PMID:8717523]"}
{"concept_id": "C3155016", "aliases": [], "types": ["T043"], "canonical_name": "T cell differentiation involved in immune response", "definition": "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155017", "aliases": [], "types": ["T043"], "canonical_name": "T cell development involved in immune response"}
{"concept_id": "C3155018", "aliases": [], "types": ["T043"], "canonical_name": "alpha-beta T cell differentiation involved in immune response", "definition": "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155019", "aliases": [], "types": ["T043"], "canonical_name": "alpha-beta T cell development involved in immune response"}
{"concept_id": "C3155020", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta T cell differentiation involved in immune response", "definition": "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155021", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta T cell development involved in immune response"}
{"concept_id": "C3155022", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response", "definition": "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response. [GOC:add, PMID:12093005]"}
{"concept_id": "C3155023", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response"}
{"concept_id": "C3155024", "aliases": [], "types": ["T043"], "canonical_name": "alpha-beta intraepithelial T cell development"}
{"concept_id": "C3155025", "aliases": ["CD8-positive, alpha-beta intraepithelial T cell development"], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta intraepithelial T cell development"}
{"concept_id": "C3155026", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta intraepithelial T cell development"}
{"concept_id": "C3155027", "aliases": [], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta T cell differentiation involved in immune response", "definition": "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155028", "aliases": [], "types": ["T043"], "canonical_name": "gamma-delta T cell differentiation involved in immune response", "definition": "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. [GOC:add]"}
{"concept_id": "C3155029", "aliases": [], "types": ["T043"], "canonical_name": "gamma-delta T cell development involved in immune response"}
{"concept_id": "C3155030", "aliases": [], "types": ["T043"], "canonical_name": "gamma-delta intraepithelial T cell development"}
{"concept_id": "C3155031", "aliases": [], "types": ["T043"], "canonical_name": "CD8-positive, gamma-delta intraepithelial T cell development"}
{"concept_id": "C3155032", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, gamma-delta intraepithelial T cell development"}
{"concept_id": "C3155033", "aliases": [], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta regulatory T cell development"}
{"concept_id": "C3155034", "aliases": [], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta cytotoxic T cell development"}
{"concept_id": "C3155035", "aliases": [], "types": ["T043"], "canonical_name": "T cell proliferation involved in immune response", "definition": "The expansion of a T cell population by cell division as part of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155036", "aliases": [], "types": ["T043"], "canonical_name": "alpha-beta T cell proliferation involved in immune response", "definition": "The expansion of an alpha-beta T cell population by cell division as part of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155037", "aliases": [], "types": ["T043"], "canonical_name": "gamma-delta T cell proliferation involved in immune response", "definition": "The expansion of a gamma-delta T cell population by cell division as part of an immune response. [GOC:add]"}
{"concept_id": "C3155039", "aliases": ["NADP+ or NADPH binding"], "types": ["T044"], "canonical_name": "NADP or NADPH binding"}
{"concept_id": "C3155042", "aliases": [], "types": ["T042"], "canonical_name": "synapse morphogenesis"}
{"concept_id": "C3155043", "aliases": [], "types": ["T039"], "canonical_name": "detection of electrical stimulus during electroreception"}
{"concept_id": "C3155044", "aliases": [], "types": ["T039"], "canonical_name": "sensory detection of electrical stimulus during electroception"}
{"concept_id": "C3155045", "aliases": [], "types": ["T039"], "canonical_name": "sensory transduction of electrical stimulus during electroception"}
{"concept_id": "C3155046", "aliases": ["sensory detection of electrical stimulus during perception of pain"], "types": ["T039"], "canonical_name": "detection of electrical stimulus during sensory perception of pain"}
{"concept_id": "C3155047", "aliases": [], "types": ["T039"], "canonical_name": "sensory transduction of electrical stimulus during perception of pain"}
{"concept_id": "C3155048", "aliases": [], "types": ["T039"], "canonical_name": "detection of electrical stimulus during magnetoreception"}
{"concept_id": "C3155049", "aliases": [], "types": ["T039"], "canonical_name": "sensory detection of electrical stimulus during magnetoreception"}
{"concept_id": "C3155050", "aliases": [], "types": ["T039"], "canonical_name": "sensory transduction of electrical stimulus during magnetoreception"}
{"concept_id": "C3155051", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription during meiosis"}
{"concept_id": "C3155052", "aliases": ["stimulation of transcription during meiosis"], "types": ["T045"], "canonical_name": "activation of transcription during meiosis"}
{"concept_id": "C3155053", "aliases": [], "types": ["T044"], "canonical_name": "6,7-dihydrobiopterin metabolic process"}
{"concept_id": "C3155054", "aliases": [], "types": ["T044"], "canonical_name": "7,8-dihydrobiopterin metabolic process"}
{"concept_id": "C3155058", "aliases": ["regulation of sequence-specific DNA binding transcription factor activity", "regulation of DNA binding transcription factor activity"], "types": ["T045"], "canonical_name": "regulation of DNA-binding transcription factor activity", "definition": "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]"}
{"concept_id": "C3155059", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription factor activity"}
{"concept_id": "C3155060", "aliases": [], "types": ["T045"], "canonical_name": "DNA ligation involved in DNA recombination", "definition": "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination. [GOC:ai]"}
{"concept_id": "C3155061", "aliases": [], "types": ["T045"], "canonical_name": "DNA ligation involved in DNA repair", "definition": "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. [GOC:ai]"}
{"concept_id": "C3155062", "aliases": ["DNA ligation involved in DNA-dependent DNA replication"], "types": ["T045"], "canonical_name": "DNA-dependent DNA replication DNA ligation", "definition": "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA-dependent DNA replication. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C3155063", "aliases": [], "types": ["T043"], "canonical_name": "regulation of NK T cell development"}
{"concept_id": "C3155064", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of NK T cell development"}
{"concept_id": "C3155065", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of NK T cell development"}
{"concept_id": "C3155067", "aliases": ["NAD+ or NADH binding"], "types": ["T044"], "canonical_name": "NAD or NADH binding"}
{"concept_id": "C3155068", "aliases": [], "types": ["T045"], "canonical_name": "chromatid release"}
{"concept_id": "C3155073", "aliases": ["attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation", "attachment of spindle microtubules to mitotic chromosome", "attachment of spindle microtubules to kinetochore involved in mitosis"], "types": ["T043"], "canonical_name": "attachment of mitotic spindle microtubules to kinetochore", "definition": "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression. [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896]"}
{"concept_id": "C3155074", "aliases": [], "types": ["T043"], "canonical_name": "mitotic bipolar attachment"}
{"concept_id": "C3155075", "aliases": ["attachment of spindle microtubules to meiotic chromosome"], "types": ["T043"], "canonical_name": "attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation", "definition": "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C3155076", "aliases": [], "types": ["T041"], "canonical_name": "proprioception during equilibrioception"}
{"concept_id": "C3155077", "aliases": [], "types": ["T040"], "canonical_name": "visual perception during equilibrioception"}
{"concept_id": "C3155086", "aliases": [], "types": ["T043"], "canonical_name": "attachment of spindle microtubules to kinetochore during meiosis I"}
{"concept_id": "C3155087", "aliases": [], "types": ["T043"], "canonical_name": "attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation", "definition": "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs. [GOC:ai, GOC:clt, GOC:dph, GOC:tb]"}
{"concept_id": "C3155088", "aliases": [], "types": ["T043"], "canonical_name": "attachment of spindle microtubules to kinetochore involved in meiosis II"}
{"concept_id": "C3155089", "aliases": [], "types": ["T043"], "canonical_name": "meiotic bipolar attachment"}
{"concept_id": "C3155090", "aliases": [], "types": ["T042"], "canonical_name": "adrenocorticotropin secretion"}
{"concept_id": "C3155091", "aliases": ["elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway", "positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway", "elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger"], "types": ["T044"], "canonical_name": "positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway", "definition": "Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. [GOC:ai, GOC:signaling]"}
{"concept_id": "C3155095", "aliases": [], "types": ["T043"], "canonical_name": "B cell activation involved in immune response", "definition": "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:jal]"}
{"concept_id": "C3155096", "aliases": [], "types": ["T043"], "canonical_name": "mature B cell differentiation involved in immune response", "definition": "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. [GOC:jal]"}
{"concept_id": "C3155097", "aliases": [], "types": ["T043"], "canonical_name": "mature B cell development involved in immune response"}
{"concept_id": "C3155098", "aliases": [], "types": ["T043"], "canonical_name": "germinal center B cell development"}
{"concept_id": "C3155099", "aliases": [], "types": ["T043"], "canonical_name": "marginal zone B cell development"}
{"concept_id": "C3155100", "aliases": [], "types": ["T043"], "canonical_name": "follicular B cell development"}
{"concept_id": "C3155101", "aliases": [], "types": ["T043"], "canonical_name": "plasma cell development"}
{"concept_id": "C3155102", "aliases": [], "types": ["T043"], "canonical_name": "memory B cell development"}
{"concept_id": "C3155103", "aliases": [], "types": ["T043"], "canonical_name": "B cell proliferation involved in immune response", "definition": "The expansion of a B cell population by cell division following B cell activation during an immune response. [GOC:jal]"}
{"concept_id": "C3155104", "aliases": [], "types": ["T043"], "canonical_name": "natural killer cell activation involved in immune response", "definition": "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, PMID:15032583]"}
{"concept_id": "C3155105", "aliases": [], "types": ["T043"], "canonical_name": "natural killer cell proliferation involved in immune response", "definition": "The expansion of a natural killer cell population by cell division as part of an immune response. [GOC:add, PMID:15032583]"}
{"concept_id": "C3155106", "aliases": [], "types": ["T043"], "canonical_name": "natural killer cell differentiation involved in immune response", "definition": "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response. [GOC:add, PMID:11698225]"}
{"concept_id": "C3155107", "aliases": [], "types": ["T043"], "canonical_name": "natural killer cell development involved in immune response"}
{"concept_id": "C3155108", "aliases": [], "types": ["T043"], "canonical_name": "immature B cell development"}
{"concept_id": "C3155109", "aliases": [], "types": ["T043"], "canonical_name": "pro-B cell development"}
{"concept_id": "C3155110", "aliases": [], "types": ["T043"], "canonical_name": "pre-B cell development"}
{"concept_id": "C3155111", "aliases": [], "types": ["T043"], "canonical_name": "transitional stage B cell development"}
{"concept_id": "C3155112", "aliases": [], "types": ["T043"], "canonical_name": "transitional one stage B cell development"}
{"concept_id": "C3155113", "aliases": [], "types": ["T043"], "canonical_name": "transitional two stage B cell development"}
{"concept_id": "C3155114", "aliases": [], "types": ["T043"], "canonical_name": "mature cell development"}
{"concept_id": "C3155115", "aliases": [], "types": ["T043"], "canonical_name": "B-1a B cell development"}
{"concept_id": "C3155116", "aliases": [], "types": ["T043"], "canonical_name": "B-1b B cell development"}
{"concept_id": "C3155117", "aliases": [], "types": ["T043"], "canonical_name": "histamine production involved in inflammatory response", "definition": "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C3155118", "aliases": [], "types": ["T043"], "canonical_name": "serotonin production involved in inflammatory response", "definition": "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149, PMID:16730260]"}
{"concept_id": "C3155119", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, CD25-positive, alpha-beta regulatory T cell development"}
{"concept_id": "C3155120", "aliases": [], "types": ["T043"], "canonical_name": "leukocyte activation involved in immune response", "definition": "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155121", "aliases": [], "types": ["T040"], "canonical_name": "cytokine production involved in immune response", "definition": "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. [GO_REF:0000022, GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155126", "aliases": ["immunoglobulin production involved in immunoglobulin mediated immune response"], "types": ["T039"], "canonical_name": "immunoglobulin production involved in immunoglobulin-mediated immune response", "definition": "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149, PMID:9185563]"}
{"concept_id": "C3155127", "aliases": [], "types": ["T038"], "canonical_name": "immunoglobulin production involved in immune response"}
{"concept_id": "C3155128", "aliases": [], "types": ["T040"], "canonical_name": "platelet activating factor production involved in inflammatory response", "definition": "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155129", "aliases": ["production of lysosomal enzymes involved in inflammatory response"], "types": ["T038"], "canonical_name": "lysosomal enzyme production involved in inflammatory response", "definition": "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels. [GOC:add]"}
{"concept_id": "C3155132", "aliases": ["DNA methyltransferase activity acting on cytosine C-5"], "types": ["T044"], "canonical_name": "cytosine C-5 DNA demethylase activity", "definition": "Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA. [PMID:10050851]"}
{"concept_id": "C3155133", "aliases": [], "types": ["T044"], "canonical_name": "hydrolytic DNA demethylase activity"}
{"concept_id": "C3155136", "aliases": [], "types": ["T043"], "canonical_name": "homologous chromosome movement towards spindle pole during meiosis I"}
{"concept_id": "C3155137", "aliases": [], "types": ["T043"], "canonical_name": "sister chromosome movement towards spindle pole during meiosis II"}
{"concept_id": "C3155142", "aliases": [], "types": ["T040"], "canonical_name": "entry into cell of other organism during symbiotic interaction"}
{"concept_id": "C3155144", "aliases": ["translocation of peptides or proteins into other organism involved in symbiotic interaction"], "types": ["T043"], "canonical_name": "translocation of peptides or proteins into other organism during symbiotic interaction"}
{"concept_id": "C3155145", "aliases": [], "types": ["T040"], "canonical_name": "passive evasion of immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155157", "aliases": [], "types": ["T046"], "canonical_name": "induction of tumor, nodule, or growth in other organism involved in symbiotic interaction"}
{"concept_id": "C3155158", "aliases": [], "types": ["T038"], "canonical_name": "induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction"}
{"concept_id": "C3155161", "aliases": [], "types": ["T040"], "canonical_name": "recognition of other organism involved in symbiotic interaction"}
{"concept_id": "C3155162", "aliases": [], "types": ["T040"], "canonical_name": "adhesion to other organism during symbiotic interaction"}
{"concept_id": "C3155163", "aliases": [], "types": ["T038"], "canonical_name": "entry into other organism during symbiotic interaction"}
{"concept_id": "C3155166", "aliases": ["avoidance of defenses of other organism involved in symbiotic interaction"], "types": ["T040"], "canonical_name": "avoidance of defenses of other organism during symbiotic interaction"}
{"concept_id": "C3155167", "aliases": [], "types": ["T040"], "canonical_name": "suppression of defenses of other organism involved in symbiotic interaction"}
{"concept_id": "C3155168", "aliases": ["evasion or tolerance of defenses of other organism involved in symbiotic interaction"], "types": ["T040"], "canonical_name": "evasion or tolerance of defenses of other organism during symbiotic interaction"}
{"concept_id": "C3155169", "aliases": ["translocation of molecules into other organism involved in symbiotic interaction"], "types": ["T044"], "canonical_name": "translocation of molecules into other organism during symbiotic interaction"}
{"concept_id": "C3155170", "aliases": ["translocation of DNA into other organism involved in symbiotic interaction"], "types": ["T043"], "canonical_name": "translocation of DNA into other organism during symbiotic interaction"}
{"concept_id": "C3155173", "aliases": ["phase II metabolism"], "types": ["T044"], "canonical_name": "phase II metabolism"}
{"concept_id": "C3155174", "aliases": [], "types": ["T043"], "canonical_name": "amino acid uptake during transmission of nerve impulse"}
{"concept_id": "C3155175", "aliases": [], "types": ["T043"], "canonical_name": "catecholamine reuptake during transmission of nerve impulse"}
{"concept_id": "C3155176", "aliases": [], "types": ["T043"], "canonical_name": "catecholamine uptake during transmission of nerve impulse"}
{"concept_id": "C3155177", "aliases": [], "types": ["T043"], "canonical_name": "glutamate uptake during transmission of nerve impulse"}
{"concept_id": "C3155178", "aliases": [], "types": ["T043"], "canonical_name": "L-glutamate uptake during transmission of nerve impulse"}
{"concept_id": "C3155179", "aliases": [], "types": ["T043"], "canonical_name": "gamma-aminobutyric acid uptake during transmission of nerve impulse"}
{"concept_id": "C3155180", "aliases": [], "types": ["T043"], "canonical_name": "regulation of catecholamine uptake during transmission of nerve impulse"}
{"concept_id": "C3155181", "aliases": [], "types": ["T043"], "canonical_name": "regulation of amino acid uptake during transmission of nerve impulse"}
{"concept_id": "C3155182", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of amino acid uptake during transmission of nerve impulse"}
{"concept_id": "C3155183", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of catecholamine uptake during transmission of nerve impulse"}
{"concept_id": "C3155184", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of catecholamine uptake during transmission of nerve impulse"}
{"concept_id": "C3155185", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glutamate uptake during transmission of nerve impulse"}
{"concept_id": "C3155186", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse"}
{"concept_id": "C3155187", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glutamate uptake during transmission of nerve impulse"}
{"concept_id": "C3155188", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse"}
{"concept_id": "C3155189", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse"}
{"concept_id": "C3155190", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glutamate uptake during transmission of nerve impulse"}
{"concept_id": "C3155191", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity", "definition": "Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP. [MetaCyc:NACGLCTRANS-RXN]"}
{"concept_id": "C3155192", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity", "definition": "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol. [EC:2.7.8.13, MetaCyc:PHOSNACMURPENTATRANS-RXN]"}
{"concept_id": "C3155193", "aliases": ["ABA-GE beta-glucosidase activity"], "types": ["T044"], "canonical_name": "abscisic acid glucose ester beta-glucosidase activity", "definition": "Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose. [PMID:16990135]"}
{"concept_id": "C3155194", "aliases": [], "types": ["T044"], "canonical_name": "P-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule. [GOC:ai]"}
{"concept_id": "C3155195", "aliases": [], "types": ["T044"], "canonical_name": "Se-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule. [GOC:ai]"}
{"concept_id": "C3155196", "aliases": ["OHCU decarboxylase activity", "4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity"], "types": ["T044"], "canonical_name": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity", "definition": "Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2. [MetaCyc:RXN-6201]"}
{"concept_id": "C3155197", "aliases": ["mannosyl-inositol phosphorylceramide anabolism", "mannose inositol phosphoceramide biosynthetic process", "mannosyl-inositol phosphorylceramide synthesis", "MIPC biosynthetic process", "mannosyl-inositol phosphorylceramide formation", "mannose-inositol-P-ceramide (MIPC) biosynthetic process", "mannosyl-inositol phosphorylceramide biosynthesis"], "types": ["T044"], "canonical_name": "mannosyl-inositol phosphorylceramide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative. [GOC:ai]"}
{"concept_id": "C3155200", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction"}
{"concept_id": "C3155205", "aliases": [], "types": ["T040"], "canonical_name": "response to defenses of other organism involved in symbiotic interaction"}
{"concept_id": "C3155207", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction"}
{"concept_id": "C3155258", "aliases": [], "types": ["T040"], "canonical_name": "modulation of signal transduction in other organism involved in symbiotic interaction"}
{"concept_id": "C3155263", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155264", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of inflammatory response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155267", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155268", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155269", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of defense response of other organism during symbiotic interaction"}
{"concept_id": "C3155270", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of phytoalexin production in other organism involved in symbiotic interaction"}
{"concept_id": "C3155277", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C3155278", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C3155279", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C3155283", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155287", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155288", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155289", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155290", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155296", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C3155306", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155307", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155311", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction"}
{"concept_id": "C3155312", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction"}
{"concept_id": "C3155315", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction"}
{"concept_id": "C3155317", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of phytoalexin production in other organism involved in symbiotic interaction"}
{"concept_id": "C3155326", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction"}
{"concept_id": "C3155339", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction"}
{"concept_id": "C3155348", "aliases": ["regulation by organism of entry into other organism involved in symbiotic interaction"], "types": ["T040"], "canonical_name": "regulation by organism of entry into other organism during symbiotic interaction"}
{"concept_id": "C3155349", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation by organism of entry into other organism involved in symbiotic interaction"}
{"concept_id": "C3155350", "aliases": [], "types": ["T040"], "canonical_name": "evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction"}
{"concept_id": "C3155353", "aliases": ["dimethylallyl-diphosphate:tRNA dimethylallyltransferase activity"], "types": ["T044"], "canonical_name": "tRNA dimethylallyltransferase activity", "definition": "Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine. [EC:2.5.1.75]"}
{"concept_id": "C3155354", "aliases": [], "types": ["T044"], "canonical_name": "tRNA prenyltransferase activity"}
{"concept_id": "C3155355", "aliases": [], "types": ["T043"], "canonical_name": "induction by organism of innate immune response in other organism involved in symbiotic interaction"}
{"concept_id": "C3155371", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction"}
{"concept_id": "C3155374", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of ethylene levels in other organism involved in symbiotic interaction"}
{"concept_id": "C3155375", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction"}
{"concept_id": "C3155376", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction"}
{"concept_id": "C3155377", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by organism of entry into cell of other organism via phagocytosis involved in symbiotic interaction"}
{"concept_id": "C3155379", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of signal transduction in other organism involved in symbiotic interaction"}
{"concept_id": "C3155383", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by organism of defense response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155387", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of signal transduction in other organism involved in symbiotic interaction"}
{"concept_id": "C3155389", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction"}
{"concept_id": "C3155391", "aliases": [], "types": ["T040"], "canonical_name": "response to phytoalexin production by other organism involved in symbiotic interaction"}
{"concept_id": "C3155392", "aliases": [], "types": ["T040"], "canonical_name": "response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction"}
{"concept_id": "C3155393", "aliases": [], "types": ["T040"], "canonical_name": "response to defense-related nitric oxide production by other organism involved in symbiotic interaction"}
{"concept_id": "C3155394", "aliases": [], "types": ["T043"], "canonical_name": "modulation by organism of immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155395", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by organism of immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155397", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by organism of immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155398", "aliases": [], "types": ["T040"], "canonical_name": "response to immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C3155399", "aliases": ["UDP-galactose metabolic process", "UDP-galactose metabolism", "UDP-D-galactopyranose metabolic process", "uridine diphosphate galactose metabolic process", "uridine diphosphate galactose metabolism", "UDP-D-galactopyranose metabolism", "UDP-D-galactose metabolism"], "types": ["T044"], "canonical_name": "UDP-D-galactose metabolic process", "definition": "The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate. [GOC:ai]"}
{"concept_id": "C3155400", "aliases": ["UDP-D-galactopyranose biosynthesis", "UDP-D-galactose biosynthesis", "uridine diphosphate galactose biosynthesis", "uridine diphosphate galactose biosynthetic process", "UDP-D-galactose biosynthetic process", "UDP-D-galactopyranose biosynthetic process", "UDP-galactose biosynthesis"], "types": ["T044"], "canonical_name": "UDP-galactose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate. [GOC:ai]"}
{"concept_id": "C3155401", "aliases": ["carbohydrate localisation"], "types": ["T039"], "canonical_name": "carbohydrate localization", "definition": "Any process in which a carbohydrate is transported to, or maintained in, a specific location. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah]"}
{"concept_id": "C3155402", "aliases": [], "types": ["T039"], "canonical_name": "carbohydrate storage", "definition": "The accumulation and maintenance in cells or tissues of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [PMID:10758476]"}
{"concept_id": "C3155403", "aliases": ["2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene D-forming] activity"], "types": ["T044"], "canonical_name": "germacrene-D synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate. [EC:4.2.3.22]"}
{"concept_id": "C3155404", "aliases": ["(E,E)-alpha-farnesene synthase activity"], "types": ["T044"], "canonical_name": "alpha-farnesene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate. [MetaCyc:RXN-8574]"}
{"concept_id": "C3155405", "aliases": ["(+)-isomenthone:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(+)-pulegone reductase, (+)-isomenthone as substrate, activity", "definition": "Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+. [EC:1.3.1.81, MetaCyc:RXN-5164]"}
{"concept_id": "C3155406", "aliases": ["(-)-menthone:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(+)-pulegone reductase, (-)-menthone as substrate, activity", "definition": "Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+. [EC:1.3.1.81, MetaCyc:RXN-5163]"}
{"concept_id": "C3155407", "aliases": ["(+)-cis-isopulegone:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "(-)-isopiperitenone reductase activity", "definition": "Catalysis of the reaction: (6R)-isoperitenone + H(+) + NADPH = (2R,5R)-isopulegone + NADP(+). [EC:1.3.1.82, RHEA:25649]"}
{"concept_id": "C3155408", "aliases": ["menthofuran synthase activity", "(+)-MFS activity", "(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating) activity", "(+)-pulegone 9-hydroxylase activity", "cytochrome P450 menthofuran synthase activity"], "types": ["T044"], "canonical_name": "(+)-menthofuran synthase activity", "definition": "Catalysis of the reaction: (R)-pulegone + H(+) + NADPH + O(2) = (R)-menthofuran + 2 H(2)O + NADP(+). [EC:1.14.14.143, RHEA:25658]"}
{"concept_id": "C3155411", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound. [GOC:ai]"}
{"concept_id": "C3155412", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound. [GOC:jl]"}
{"concept_id": "C3155413", "aliases": ["(R)-acetoin dehydrogenase activity"], "types": ["T044"], "canonical_name": "diacetyl reductase ((R)-acetoin forming) activity", "definition": "Catalysis of the reaction: (R)-acetoin + NAD(+) = diacetyl + H(+) + NADH. [EC:1.1.1.303, RHEA:22900]"}
{"concept_id": "C3155414", "aliases": ["(S)-acetoin dehydrogenase activity"], "types": ["T044"], "canonical_name": "diacetyl reductase ((S)-acetoin forming) activity", "definition": "Catalysis of the reaction: (S)-acetoin + NAD(+) = diacetyl + H(+) + NADH. [EC:1.1.1.304, RHEA:27286]"}
{"concept_id": "C3155415", "aliases": ["(S)-malate:(menaquinone) oxidoreductase activity", "(S)-malate:menaquinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "malate dehydrogenase (menaquinone) activity", "definition": "Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol. [MetaCyc:RXNI-3]"}
{"concept_id": "C3155416", "aliases": [], "types": ["T044"], "canonical_name": "sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol. [MetaCyc:RXN0-5258]"}
{"concept_id": "C3155417", "aliases": [], "types": ["T044"], "canonical_name": "sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8. [MetaCyc:GLYC3PDEHYDROG-RXN]"}
{"concept_id": "C3155418", "aliases": ["oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulphur protein as acceptor"], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. [GOC:ai]"}
{"concept_id": "C3155419", "aliases": [], "types": ["T044"], "canonical_name": "tryptamine:oxygen oxidoreductase (deaminating) activity", "definition": "Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+. [MetaCyc:RXN-1401]"}
{"concept_id": "C3155420", "aliases": [], "types": ["T044"], "canonical_name": "aminoacetone:oxygen oxidoreductase(deaminating) activity", "definition": "Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+. [MetaCyc:AMACETOXID-RXN]"}
{"concept_id": "C3155421", "aliases": ["aliphatic-amine:oxygen oxidoreductase(deaminating) activity"], "types": ["T044"], "canonical_name": "aliphatic-amine oxidase activity", "definition": "Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. [MetaCyc:AMINEOXID-RXN]"}
{"concept_id": "C3155422", "aliases": [], "types": ["T044"], "canonical_name": "phenethylamine:oxygen oxidoreductase (deaminating) activity", "definition": "Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. [MetaCyc:AMINEPHEN-RXN]"}
{"concept_id": "C3155423", "aliases": ["diamine:oxygen oxidoreductase (deaminating) activity"], "types": ["T044"], "canonical_name": "diamine oxidase activity", "definition": "Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide. [MetaCyc:RXN-9599]"}
{"concept_id": "C3155424", "aliases": ["1H-Imidazole-4-ethanamine oxidase activity", "1H-Imidazole-4-ethanamine:oxygen oxidoreductase (deaminating) activity", "histamine:oxygen oxidoreductase (deaminating) activity"], "types": ["T044"], "canonical_name": "histamine oxidase activity", "definition": "Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+. [MetaCyc:RXN-9600]"}
{"concept_id": "C3155425", "aliases": ["N-methylputrescine:oxygen oxidoreductase (deaminating) activity"], "types": ["T044"], "canonical_name": "methylputrescine oxidase activity", "definition": "Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+. [MetaCyc:RXN-8244]"}
{"concept_id": "C3155426", "aliases": ["propane-1,3-diamine:oxygen oxidoreductase (deaminating) activity", "trimethylenediamine oxidase activity", "1,3-diaminopropane oxidase activity"], "types": ["T044"], "canonical_name": "propane-1,3-diamine oxidase activity", "definition": "Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+. [MetaCyc:RXN-6381]"}
{"concept_id": "C3155427", "aliases": ["(S)-limonene,NAD(P)H:oxygen oxidoreductase activity", "(-)-limonene 1,2-monooxygenase activity", "(-)-limonene,NAD(P)H:oxygen oxidoreductase activity"], "types": ["T044"], "canonical_name": "(S)-limonene 1,2-monooxygenase activity", "definition": "Catalysis of the reaction: (4S)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4S)-limonene-1,2-epoxide. [MetaCyc:RXN-9409, PMID:8820855]"}
{"concept_id": "C3155428", "aliases": [], "types": ["T044"], "canonical_name": "4-chloronitrobenzene nitroreductase activity", "definition": "Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O. [MetaCyc:RXN-8833]"}
{"concept_id": "C3155429", "aliases": [], "types": ["T044"], "canonical_name": "1-chloro-4-nitrosobenzene nitroreductase activity", "definition": "Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O. [MetaCyc:RXN-8834]"}
{"concept_id": "C3155430", "aliases": [], "types": ["T044"], "canonical_name": "delta-tocopherol cyclase activity", "definition": "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol. [MetaCyc:RXN-2561, PMID:12213958]"}
{"concept_id": "C3155431", "aliases": [], "types": ["T044"], "canonical_name": "gamma-tocopherol cyclase activity", "definition": "Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol. [MetaCyc:RXN-2543, PMID:12213958]"}
{"concept_id": "C3155433", "aliases": [], "types": ["T044"], "canonical_name": "echinenone 3-hydroxylase activity", "definition": "Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O. [MetaCyc:RXN-8214]"}
{"concept_id": "C3155434", "aliases": ["beta-ring carotenoid 3-hydroxylase activity"], "types": ["T044"], "canonical_name": "beta-ring carotenoid 3-hydroxylase activity"}
{"concept_id": "C3155435", "aliases": [], "types": ["T044"], "canonical_name": "4-ketotorulene 3-hydroxylase activity", "definition": "Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O. [MetaCyc:RXN-8218]"}
{"concept_id": "C3155436", "aliases": [], "types": ["T044"], "canonical_name": "beta-cryptoxanthin hydroxylase activity", "definition": "Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O. [RHEA:30327]"}
{"concept_id": "C3155437", "aliases": [], "types": ["T044"], "canonical_name": "beta-carotene 3-hydroxylase activity", "definition": "Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O. [RHEA:30323]"}
{"concept_id": "C3155438", "aliases": [], "types": ["T044"], "canonical_name": "adonirubin 3-hydroxylase activity", "definition": "Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O. [MetaCyc:RXN-8187]"}
{"concept_id": "C3155439", "aliases": [], "types": ["T044"], "canonical_name": "canthaxanthin 3-hydroxylase activity", "definition": "Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O. [MetaCyc:RXN-8186]"}
{"concept_id": "C3155440", "aliases": [], "types": ["T044"], "canonical_name": "uracil oxygenase activity", "definition": "Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate. [MetaCyc:RXN0-6444, PMID:20369853, PMID:20400551]"}
{"concept_id": "C3155441", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine oxygenase activity"}
{"concept_id": "C3155442", "aliases": [], "types": ["T044"], "canonical_name": "ent-kaur-16-en-19-ol oxidase activity", "definition": "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al. [MetaCyc:RXN-5242]"}
{"concept_id": "C3155443", "aliases": [], "types": ["T044"], "canonical_name": "ent-kaur-16-en-19-al oxidase activity", "definition": "Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate. [MetaCyc:RXN-7580]"}
{"concept_id": "C3155444", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme F420-0:L-glutamate ligase activity", "definition": "Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate. [MetaCyc:RXN-8080]"}
{"concept_id": "C3155445", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme F420-1:gamma-L-glutamate ligase activity", "definition": "Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate. [MetaCyc:RXN-8081]"}
{"concept_id": "C3155446", "aliases": [], "types": ["T044"], "canonical_name": "thymine dehydrogenase activity", "definition": "Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2. [RHEA:13469]"}
{"concept_id": "C3155447", "aliases": ["2-isopentenyl-diphosphate:ATP delta2-isopentenyltransferase activity", "ATP isopentenyltransferase activity", "dimethylallyl-diphosphate:ATP dimethylallyltransferase activity", "2-isopentenyl-diphosphate:ATP 2-isopentenyltransferase activity"], "types": ["T044"], "canonical_name": "ATP dimethylallyltransferase activity", "definition": "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate. [EC:2.5.1.27, MetaCyc:RXN-4303]"}
{"concept_id": "C3155448", "aliases": ["dimethylallyl-diphosphate:ADP dimethylallyltransferase activity", "2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity", "ADP isopentenyltransferase activity", "2-isopentenyl-diphosphate:ADP delta2-isopentenyltransferase activity"], "types": ["T044"], "canonical_name": "ADP dimethylallyltransferase activity", "definition": "Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate. [EC:2.5.1.27, MetaCyc:RXN-4305]"}
{"concept_id": "C3155449", "aliases": ["S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinone methyltransferase activity", "S-adenosyl-L-methionine:demethylphylloquinone methyltransferase activity", "demethylphylloquinone methyltransferase activity", "S-adenosyl-L-methionine:salicylate carboxyl methyltransferase activity"], "types": ["T044"], "canonical_name": "2-phytyl-1,4-naphthoquinone methyltransferase activity", "definition": "Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+. [MetaCyc:RXN-6723, MetaCyc:RXN-7569, PMID:14617060]"}
{"concept_id": "C3155450", "aliases": [], "types": ["T044"], "canonical_name": "salicylate methyltransferase activity"}
{"concept_id": "C3155451", "aliases": ["salicylic acid methyltransferase activity"], "types": ["T044"], "canonical_name": "SA methyltransferase activity"}
{"concept_id": "C3155452", "aliases": ["p-aminobenzoate amino acid synthetase activity", "p-aminobenzoyl amino acid synthetase activity", "pABA amino acid synthetase activity", "4-aminobenzoyl amino acid synthetase activity"], "types": ["T044"], "canonical_name": "4-aminobenzoate amino acid synthetase activity", "definition": "Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate. [MetaCyc:RXN-10884, PMID:19189963]"}
{"concept_id": "C3155453", "aliases": ["benzoyl amino acid synthetase activity"], "types": ["T044"], "canonical_name": "benzoate amino acid synthetase activity", "definition": "Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate. [MetaCyc:RXN-10886, PMID:19189963]"}
{"concept_id": "C3155454", "aliases": [], "types": ["T044"], "canonical_name": "vanillate amino acid synthetase activity", "definition": "Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate. [MetaCyc:RXN-10885, PMID:19189963]"}
{"concept_id": "C3155455", "aliases": ["4HBA amino acid synthetase activity", "p-hydroxybenzoate amino acid synthetase activity", "p-hydroxybenzoyl amino acid synthetase activity", "4-hydroxybenzoyl amino acid synthetase activity"], "types": ["T044"], "canonical_name": "4-hydroxybenzoate amino acid synthetase activity", "definition": "Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate. [MetaCyc:RXN-10884, PMID:19189963]"}
{"concept_id": "C3155456", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. [PMID:19901554, RHEA:39019]"}
{"concept_id": "C3155457", "aliases": ["uridine diphosphoacetylgalactosamine phosphorylase activity", "UDP-GalNAc pyrophosphorylase activity", "UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase activity", "N-acetylgalactosamine 1-phosphate uridylyltransferase", "uridine diphosphate-N-acetylgalactosamine pyrophosphorylase activity", "UDP-N-acetylgalactosamine pyrophosphorylase activity", "UTP:2-acetamido-2-deoxy-alpha-D-galactose-1-phosphate uridylyltransferase activity", "UDP-acetylgalactosamine pyrophosphorylase activity", "uridine diphosphoacetylgalactosamine pyrophosphorylase activity", "N-acetylgalactosamine-1-phosphate uridyltransferase activity"], "types": ["T044"], "canonical_name": "UDP-N-acetylgalactosamine diphosphorylase activity", "definition": "Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine. [EC:2.7.7.83, RHEA:34363]"}
{"concept_id": "C3155458", "aliases": [], "types": ["T044"], "canonical_name": "sphingolipid delta-8 desaturase activity", "definition": "Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8). [PMID:17600137, PMID:9786850]"}
{"concept_id": "C3155460", "aliases": [], "types": ["T044"], "canonical_name": "isocitrate hydro-lyase (cis-aconitate-forming) activity", "definition": "Catalysis of the reaction: cis-aconitate + H2O = isocitrate. [EC:4.2.1.3, GOC:pde, GOC:vw, MetaCyc:ACONITATEHYDR-RXN]"}
{"concept_id": "C3155461", "aliases": ["(C-19 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)", "C-19 gibberellin 2-beta-hydroxylase activity", "C(19) gibberellin 2-oxidase activity", "C-19 GA 2-oxidase activity", "C-19 gibberellin 2-oxidase activity", "C-19 gibberellin 2beta-hydroxylase activity", "C-19 gibberellin 2beta-dioxygenase activity"], "types": ["T044"], "canonical_name": "C-19 gibberellin 2-beta-dioxygenase activity", "definition": "Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons. [EC:1.14.11.13, GOC:kad]"}
{"concept_id": "C3155462", "aliases": ["C-20 GA 2-oxidase activity", "(C-20 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)", "C-20 gibberellin 2beta-hydroxylase activity", "C-20 gibberellin 2-beta-hydroxylase activity", "C(20) gibberellin 2-oxidase activity", "C-20 gibberellin 2-oxidase activity", "C-20 gibberellin 2beta-dioxygenase activity"], "types": ["T044"], "canonical_name": "C-20 gibberellin 2-beta-dioxygenase activity", "definition": "Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons. [EC:1.14.11.13, GOC:kad]"}
{"concept_id": "C3155463", "aliases": ["arabinosyl transferase activity"], "types": ["T044"], "canonical_name": "arabinosyltransferase activity", "definition": "Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor). [GOC:ai]"}
{"concept_id": "C3155464", "aliases": [], "types": ["T044"], "canonical_name": "delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol. [GOC:ai, MetaCyc:RXN-8319, PMID:19682287]"}
{"concept_id": "C3155465", "aliases": ["UDP-glucose:indol-3-ylbutyrate glucosyl-transferase activity", "indol-3-ylbutyrylglucose synthase activity", "IBAGlu synthase activity", "IBA-glucose synthase activity", "UDP-glucose:(indol-3-yl)butyrate beta-D-glucosyltransferase activity", "uridine diphosphoglucose-indolebutyrate glucosyltransferase activity", "indole-3-butyric acid glucosyltransferase activity", "IBA-Glc synthetase activity", "UDP-glucose:indol-3-ylbutyrate glucosyltransferase activity", "UDPG-indol-3-ylbutyryl glucosyl transferase activity", "UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "indole-3-butyrate beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP. [MetaCyc:RXN-11655, RHEA:62708]"}
{"concept_id": "C3155466", "aliases": ["UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity", "UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity", "UDP:glucose:salicylate glucosyltransferase (ester-forming) activity", "UDP:glucose:SA glucosyltransferase (ester-forming) activity"], "types": ["T044"], "canonical_name": "salicylic acid glucosyltransferase (ester-forming) activity", "definition": "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP. [MetaCyc:RXN-11659, RHEA:62316]"}
{"concept_id": "C3155467", "aliases": ["salicylic acid glucosyltransferase activity"], "types": ["T044"], "canonical_name": "salicylic acid glucosyltransferase activity"}
{"concept_id": "C3155468", "aliases": ["UDP:glucose:SA glucosyltransferase (glucoside-forming) activity", "UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity", "UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity", "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity"], "types": ["T044"], "canonical_name": "salicylic acid glucosyltransferase (glucoside-forming) activity", "definition": "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP. [MetaCyc:RXN-11658, RHEA:62312]"}
{"concept_id": "C3155469", "aliases": ["benzoate glucosyltransferase activity", "UDP:glucose:BA glucosyltransferase activity", "UDP:glucose:benzoic acid glucosyltransferase activity", "UDP:glucose:benzoate glucosyltransferase activity"], "types": ["T044"], "canonical_name": "benzoic acid glucosyltransferase activity", "definition": "Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP. [MetaCyc:RXN-11660]"}
{"concept_id": "C3155470", "aliases": ["LPA phosphatase activity", "lysophosphatidate phosphatase activity"], "types": ["T044"], "canonical_name": "lysophosphatidic acid phosphatase activity", "definition": "Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol. [PMID:20045079, PMID:7966317]"}
{"concept_id": "C3155471", "aliases": ["chlorophyllide metabolism"], "types": ["T044"], "canonical_name": "chlorophyllide metabolic process", "definition": "The chemical reactions and pathways involving chlorophyllides, any chlorophyll lacking the terpenoid side chain such as phytyl or farnesyl. [PMID:7724548]"}
{"concept_id": "C3155472", "aliases": ["chlorophyllide a metabolism"], "types": ["T044"], "canonical_name": "chlorophyllide a metabolic process", "definition": "The chemical reactions and pathways involving chlorophyllide a, a chlorophyll lacking the terpenoid side chain, which is the functional parent of chlorophyll a. [PMID:7724548]"}
{"concept_id": "C3155473", "aliases": ["coenzyme F420-0 metabolism", "F(420)-0 metabolic process", "coenzyme F420-0 metabolic process", "F420-0 metabolism"], "types": ["T044"], "canonical_name": "F420-0 metabolic process", "definition": "The chemical reactions and pathways involving F420-0 (5-O-{[(1S)-1-carboxyethoxy](hydroxy)phosphoryl}-1-deoxy-1-(8-hydroxy-2,4-dioxo-2H-pyrimido[4,5-b]quinolin-10(4H)-yl)-D-ribitol), the fragment of coenzyme F420 remaining after formal hydrolytic removal of all of the glutamate residues. [GOC:curators]"}
{"concept_id": "C3155474", "aliases": ["alditol phosphate metabolism"], "types": ["T044"], "canonical_name": "alditol phosphate metabolic process", "definition": "The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. [PMID:30240188]"}
{"concept_id": "C3155475", "aliases": ["pentitol phosphate metabolism"], "types": ["T044"], "canonical_name": "pentitol phosphate metabolic process", "definition": "The chemical reactions and pathways involving pentitol phosphates, any phosphorylated alditol with a chain of five carbon atoms in the molecule. [ISBN:0198506732]"}
{"concept_id": "C3155476", "aliases": ["ribitol phosphate metabolism"], "types": ["T044"], "canonical_name": "ribitol phosphate metabolic process", "definition": "The chemical reactions and pathways involving ribitol phosphates, any phosphorylated form of ribitol, the pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. [ISBN:0198506732]"}
{"concept_id": "C3155477", "aliases": ["F420-2 metabolism", "coenzyme gamma-F420-2 metabolism", "coenzyme F420 metabolism", "coenzyme F420 metabolic process", "F420-2 metabolic process"], "types": ["T044"], "canonical_name": "coenzyme gamma-F420-2 metabolic process", "definition": "The chemical reactions and pathways involving coenzyme gamma-F420-2 (F420-2; coenzyme F420; N-{N-[O-(7,8-didemethyl-8-hydroxy-5-deazariboflavin phospho)-(S)-lactyl]-gamma-L-glutamyl}-L-glutamate), the amide obtained by formal condensation of the carboxylic acid group of F420-0 with the amino group of L-gamma-glutamyl-L-glutamic acid. [GOC:curators]"}
{"concept_id": "C3155478", "aliases": ["retinol:NADP+ oxidoreductase activity", "retinol dehydrogenase activity", "NADP-retinol dehydrogenase activity", "retinol dehydrogenase [NADP+] activity"], "types": ["T044"], "definition": "Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. [RHEA:25033]", "canonical_name": "NADP(H)-dependent retinol dehydrogenase/reductase activity"}
{"concept_id": "C3155479", "aliases": [], "types": ["T044"], "canonical_name": "all-trans retinal reductase activity"}
{"concept_id": "C3155480", "aliases": ["monoacylglycerol catabolism", "monoacylglycerol breakdown", "monoacylglycerol degradation"], "types": ["T044"], "canonical_name": "monoacylglycerol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [PMID:25290914]"}
{"concept_id": "C3155481", "aliases": ["cyclic purine nucleotide metabolism"], "types": ["T044"], "canonical_name": "cyclic purine nucleotide metabolic process", "definition": "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine. [PMID:23911318]"}
{"concept_id": "C3155482", "aliases": ["cyclic diguanylate metabolic process", "3',5'-cyclic diguanylic acid metabolism", "cdiGMP metabolic process", "cyclic diguanylate metabolism", "cdiGMP metabolism"], "types": ["T044"], "canonical_name": "3',5'-cyclic diguanylic acid metabolic process", "definition": "The chemical reactions and pathways involving 3',5'-cyclic diguanylic acid, a cyclic purine dinucleotide in which the base groups are guanine. [GOC:curators]"}
{"concept_id": "C3155483", "aliases": ["L-valine aminotransferase activity"], "types": ["T044"], "canonical_name": "L-valine transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid. [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN]"}
{"concept_id": "C3155484", "aliases": ["L-isoleucine aminotransferase activity"], "types": ["T044"], "canonical_name": "L-isoleucine transaminase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN]"}
{"concept_id": "C3155486", "aliases": ["InsP3 5-phosphatase activity"], "types": ["T044"], "canonical_name": "InsP(3) 5-phosphatase activity"}
{"concept_id": "C3155487", "aliases": ["D-myo-inositol (1,3,4,5)-polyphosphate 5-phosphatase activity", "Ins(1,3,4,5)P4 5-phosphatase activity", "Ins(1,3,4,5)P(4) 5-phosphatase activity"], "types": ["T044"], "canonical_name": "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [EC:3.1.3.56, RHEA:11392]"}
{"concept_id": "C3155488", "aliases": ["D-lactaldehyde:propanediol oxidoreductase activity", "(R)-propane-1,2-diol:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "R-lactaldehyde reductase activity", "definition": "Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+. [RHEA:23872]"}
{"concept_id": "C3155490", "aliases": ["S-adenosyl-L-methionine:tRNA uracil-2'-O-methyltransferase activity", "tRNA uracil-2'-O-methyltransferase activity", "tRNA uracil 2'-methyltransferase activity", "S-adenosyl-L-methionine:tRNA (uracil-2'-O-)-methyltransferase activity", "tRNA (uracil 2')-methyltransferase activity", "transfer ribonucleate uracil 2'-methyltransferase activity"], "types": ["T044"], "canonical_name": "tRNA (uracil-2'-O-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil. [PMID:25626150, RHEA:43100]"}
{"concept_id": "C3155491", "aliases": ["tRNA (cytosine 2')-methyltransferase activity", "tRNA cytosine-2'-O-methyltransferase activity", "S-adenosyl-L-methionine:tRNA (cytosine-2'-O-)-methyltransferase activity", "transfer ribonucleate cytosine 2'-methyltransferase activity", "S-adenosyl-L-methionine:tRNA cytosine-2'-O-methyltransferase activity", "tRNA cytosine 2'-methyltransferase activity"], "types": ["T045"], "canonical_name": "tRNA (cytosine-2'-O-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine. [GOC:hjd]"}
{"concept_id": "C3155492", "aliases": ["N-methylethanolamine phosphate N-methyltransferase activity", "S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase activity"], "types": ["T044"], "canonical_name": "phosphomethylethanolamine N-methyltransferase activity", "definition": "Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+). [RHEA:25321]"}
{"concept_id": "C3155493", "aliases": ["farnesol kinase activity", "farnesol phosphotransferase activity", "CTP:2-trans,-6-trans-farnesol kinase activity", "CTP:2-trans,-6-trans-farnesol phosphotransferase activity"], "types": ["T044"], "canonical_name": "CTP:farnesol kinase activity", "definition": "Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+. [PMID:21395888, RHEA:51680]"}
{"concept_id": "C3155494", "aliases": [], "types": ["T044"], "canonical_name": "trans,trans-farnesol kinase activity"}
{"concept_id": "C3155496", "aliases": ["geraniol phosphotransferase activity"], "types": ["T044"], "canonical_name": "geraniol kinase activity", "definition": "Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate. [GOC:kd]"}
{"concept_id": "C3155497", "aliases": ["geranylgeraniol phosphotransferase activity"], "types": ["T044"], "canonical_name": "geranylgeraniol kinase activity", "definition": "Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate. [GOC:kd, MetaCyc:RXN-11629]"}
{"concept_id": "C3155498", "aliases": ["CTP:geranylgeraniol phosphotransferase activity"], "types": ["T044"], "canonical_name": "CTP:geranylgeraniol kinase activity", "definition": "Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP. [MetaCyc:RXN-11629]"}
{"concept_id": "C3155499", "aliases": ["prenyl alcohol phosphotransferase activity", "prenol phosphotransferase activity", "prenyl alcohol kinase activity"], "types": ["T044"], "canonical_name": "prenol kinase activity", "definition": "Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity. [GOC:ai, GOC:kd]"}
{"concept_id": "C3155500", "aliases": ["ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] activity"], "types": ["T044"], "canonical_name": "ent-pimara-9(11),15-diene synthase activity", "definition": "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate. [RHEA:25544]"}
{"concept_id": "C3155501", "aliases": [], "types": ["T044"], "canonical_name": "PMD synthase activity"}
{"concept_id": "C3155502", "aliases": ["3-methylbutanol:NADP+ oxidoreductase activity", "isoamyl alcohol oxidase (NADP) activity", "3-methylbutanal reductase (NADP) activity", "3-methylbutyraldehyde reductase (NADP) activity"], "types": ["T044"], "canonical_name": "3-methylbutanol:NADP oxidoreductase activity", "definition": "Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde. [EC:1.1.1.265, KEGG_REACTION:R05686]"}
{"concept_id": "C3155503", "aliases": ["3-methylbutyraldehyde reductase (NAD) activity", "isoamyl alcohol oxidase (NAD) activity", "3-methylbutanol:NAD+ oxidoreductase activity", "3-methylbutanal reductase (NAD) activity"], "types": ["T044"], "canonical_name": "3-methylbutanol:NAD oxidoreductase activity", "definition": "Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde. [EC:1.1.1.265, KEGG_REACTION:R05685]"}
{"concept_id": "C3155504", "aliases": ["D-arabinitol:NADP+ dehydrogenase activity"], "types": ["T044"], "canonical_name": "D-arabinitol:NADP+ dehydrogenase activity"}
{"concept_id": "C3155505", "aliases": ["NADP+-dependent D-arabinitol dehydrogenase activity"], "types": ["T044"], "canonical_name": "NADP+-dependent D-arabinitol dehydrogenase activity"}
{"concept_id": "C3155506", "aliases": ["ent-copalyl-diphosphate diphosphate-lyase [ent-abieta-8(14),12-diene-forming] activity"], "types": ["T044"], "canonical_name": "levopimaradiene synthase activity", "definition": "Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate. [RHEA:25548]"}
{"concept_id": "C3155507", "aliases": ["terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) activity"], "types": ["T044"], "canonical_name": "terpentetriene synthase activity", "definition": "Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene. [RHEA:25617]"}
{"concept_id": "C3155508", "aliases": ["(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] activity"], "types": ["T044"], "canonical_name": "epi-isozizaene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate. [RHEA:25992]"}
{"concept_id": "C3155509", "aliases": ["(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] activity"], "types": ["T044"], "canonical_name": "alpha-bisabolene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate. [RHEA:25436]"}
{"concept_id": "C3155510", "aliases": [], "types": ["T044"], "canonical_name": "bisabolene synthase activity"}
{"concept_id": "C3155511", "aliases": ["epicedrol synthase activity", "(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) activity", "8-epicedrol synthase activity"], "types": ["T044"], "canonical_name": "epi-cedrol synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate. [RHEA:26115]"}
{"concept_id": "C3155512", "aliases": ["(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] activity"], "types": ["T044"], "canonical_name": "(Z)-gamma-bisabolene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate. [RHEA:26081]"}
{"concept_id": "C3155513", "aliases": ["L-serine hydro-lyase (adding indole; L-tryptophan-forming) activity"], "types": ["T044"], "canonical_name": "L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity", "definition": "Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O. [MetaCyc:RXN0-2382]"}
{"concept_id": "C3155514", "aliases": [], "types": ["T044"], "canonical_name": "tryptophan synthase beta subunit activity"}
{"concept_id": "C3155515", "aliases": ["perillic acid:CoA ligase (ADP-forming) activity"], "types": ["T044"], "canonical_name": "perillic acid-CoA ligase (ADP-forming) activity", "definition": "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA. [KEGG_REACTION:R06368]"}
{"concept_id": "C3155516", "aliases": ["perillic acid:CoA ligase (AMP-forming) activity"], "types": ["T044"], "canonical_name": "perillic acid-CoA ligase (AMP-forming) activity", "definition": "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA. [KEGG_REACTION:R06368]"}
{"concept_id": "C3155517", "aliases": [], "types": ["T044"], "canonical_name": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity", "definition": "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. [KEGG_REACTION:R06396]"}
{"concept_id": "C3155518", "aliases": [], "types": ["T044"], "canonical_name": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity", "definition": "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. [KEGG_REACTION:R06515]"}
{"concept_id": "C3155519", "aliases": ["trichlorohydroquinone reductive dehalogenase activity"], "types": ["T044"], "canonical_name": "trichloro-p-hydroquinone reductive dehalogenase activity", "definition": "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl. [PMID:1459949, RHEA:56832, UM-BBD_reactionID:r0315]"}
{"concept_id": "C3155520", "aliases": ["xenobiotic reductase activity"], "types": ["T044"], "canonical_name": "xenobiotic reductase activity"}
{"concept_id": "C3155521", "aliases": ["UDP-L-Ara mutase activity", "UDP-L-arabinose mutase activity", "uridine-diphosphate-L-arabinose mutase activity", "UDP-arabinopyranose pyranomutase activity", "UDP-L-arabinopyranose furanomutase activity"], "types": ["T044"], "canonical_name": "UDP-arabinopyranose mutase activity", "definition": "Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose. [EC:5.4.99.30, RHEA:28350]"}
{"concept_id": "C3155522", "aliases": ["raffinose-specific alkaline alpha-galactosidase activity"], "types": ["T044"], "canonical_name": "raffinose alpha-galactosidase activity", "definition": "Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose. [MetaCyc:RXN-11502]"}
{"concept_id": "C3155523", "aliases": [], "types": ["T044"], "canonical_name": "alkaline alpha-galactosidase activity"}
{"concept_id": "C3155524", "aliases": [], "types": ["T044"], "canonical_name": "raffinose galactohydrolase activity"}
{"concept_id": "C3155525", "aliases": [], "types": ["T044"], "canonical_name": "epoxyqueuosine reductase activity", "definition": "Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant. [PMID:21502530, RHEA:32159]"}
{"concept_id": "C3155526", "aliases": [], "types": ["T026"], "canonical_name": "endosome recycling compartment"}
{"concept_id": "C3155529", "aliases": [], "types": ["T042"], "canonical_name": "entry into diapause", "definition": "The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. [GOC:ds, GOC:jid, GOC:mah]"}
{"concept_id": "C3155530", "aliases": [], "types": ["T042"], "canonical_name": "entry into reproductive diapause", "definition": "The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. [GOC:ds, GOC:jid, GOC:mah]"}
{"concept_id": "C3155531", "aliases": [], "types": ["T044"], "canonical_name": "pyrrolidine-2-carboxylic acid biosynthetic process"}
{"concept_id": "C3155532", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardiomyocyte proliferation"}
{"concept_id": "C3155533", "aliases": [], "types": ["T043"], "canonical_name": "histamine secretion involved in inflammatory response", "definition": "The regulated release of histamine by a cell as part of an inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155534", "aliases": [], "types": ["T043"], "canonical_name": "serotonin secretion involved in inflammatory response", "definition": "The regulated release of serotonin by a cell as part of an inflammatory response. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155535", "aliases": [], "types": ["T043"], "canonical_name": "leukocyte migration involved in inflammatory response", "definition": "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]"}
{"concept_id": "C3155536", "aliases": [], "types": ["T039"], "canonical_name": "vasodilation involved in acute inflammatory response", "definition": "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response. [GOC:jal]"}
{"concept_id": "C3155537", "aliases": [], "types": ["T039"], "canonical_name": "regulation of vascular permeability involved in acute inflammatory response", "definition": "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response. [GOC:jal]"}
{"concept_id": "C3155538", "aliases": [], "types": ["T040"], "canonical_name": "regulation of systemic arterial blood pressure involved in acute-phase response", "definition": "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein. [GOC:jal, ISBN:081533642X]"}
{"concept_id": "C3155539", "aliases": [], "types": ["T039"], "canonical_name": "regulation of heart contraction involved in acute-phase response", "definition": "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein. [GOC:jal, PMID:15642986, PMID:15834430]"}
{"concept_id": "C3155540", "aliases": [], "types": ["T038"], "canonical_name": "production of molecular mediator involved in inflammatory response", "definition": "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]"}
{"concept_id": "C3155541", "aliases": ["secretion of lysosomal enzymes involved in inflammatory response"], "types": ["T043"], "canonical_name": "lysosomal enzyme secretion involved in inflammatory response", "definition": "The regulated release of lysosomal enzymes by a cell as part of an inflammatory response. [GOC:jal, PMID:11836514]"}
{"concept_id": "C3155542", "aliases": [], "types": ["T040"], "canonical_name": "cytokine production involved in inflammatory response", "definition": "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155544", "aliases": [], "types": ["T038"], "canonical_name": "respiratory burst involved in inflammatory response", "definition": "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155545", "aliases": ["production of nitric oxide involved in inflammatory response"], "types": ["T038"], "canonical_name": "nitric oxide production involved in inflammatory response", "definition": "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155546", "aliases": ["production of arachidonic acid metabolites involved in inflammatory response"], "types": ["T038"], "canonical_name": "arachidonic acid metabolite production involved in inflammatory response", "definition": "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155547", "aliases": [], "types": ["T038"], "canonical_name": "prostaglandin production involved in inflammatory response", "definition": "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155548", "aliases": [], "types": ["T038"], "canonical_name": "leukotriene production involved in inflammatory response", "definition": "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]"}
{"concept_id": "C3155549", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cytokine production involved in immune response", "definition": "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. [GOC:add]"}
{"concept_id": "C3155550", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of cytokine production involved in immune response", "definition": "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. [GOC:add]"}
{"concept_id": "C3155557", "aliases": [], "types": ["T040"], "canonical_name": "regulation of type 2 immune response", "definition": "Any process that modulates the frequency, rate, or extent of a type 2 immune response. [GOC:add]"}
{"concept_id": "C3155558", "aliases": ["down-regulation of type 2 immune response", "down regulation of type 2 immune response", "downregulation of type 2 immune response"], "types": ["T040"], "canonical_name": "negative regulation of type 2 immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. [GOC:add]"}
{"concept_id": "C3155559", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of type 2 immune response"}
{"concept_id": "C3155560", "aliases": ["up regulation of type 2 immune response", "upregulation of type 2 immune response", "up-regulation of type 2 immune response"], "types": ["T040"], "canonical_name": "positive regulation of type 2 immune response", "definition": "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. [GOC:add]"}
{"concept_id": "C3155561", "aliases": [], "types": ["T040"], "canonical_name": "activation of type 2 immune response"}
{"concept_id": "C3155562", "aliases": [], "types": ["T040"], "canonical_name": "stimulation of type 2 immune response"}
{"concept_id": "C3155564", "aliases": [], "types": ["T042"], "canonical_name": "follicular fluid formation in ovarian follicle antrum involved in fused antrum stage", "definition": "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis. [GOC:dph, GOC:isa_complete]"}
{"concept_id": "C3155565", "aliases": [], "types": ["T042"], "canonical_name": "follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage", "definition": "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis. [GOC:dph, GOC:isa_complete]"}
{"concept_id": "C3155566", "aliases": [], "types": ["T042"], "canonical_name": "follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage", "definition": "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis. [GOC:dph, GOC:isa_complete]"}
{"concept_id": "C3155569", "aliases": [], "types": ["T040"], "canonical_name": "vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure", "definition": "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. [ISBN:0323031951]"}
{"concept_id": "C3155570", "aliases": [], "types": ["T040"], "canonical_name": "vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure", "definition": "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. [GOC:mtg_cardio]"}
{"concept_id": "C3155572", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of glomerular filtration by angiotensin", "definition": "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C3155574", "aliases": [], "types": ["T042"], "canonical_name": "trabecula carnea morphogenesis"}
{"concept_id": "C3155576", "aliases": ["sequence-specific DNA binding transcription factor activity", "gene-specific transcription factor activity", "DNA binding transcription factor activity"], "types": ["T045"], "canonical_name": "DNA-binding transcription factor activity", "definition": "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]"}
{"concept_id": "C3155579", "aliases": [], "types": ["T039"], "canonical_name": "oviduct development", "definition": "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. [GOC:dph, GOC:ebc, http://www.thefreedictionary.com/oviduct]"}
{"concept_id": "C3155580", "aliases": [], "types": ["T043"], "canonical_name": "regulation of EPSP"}
{"concept_id": "C3155581", "aliases": [], "types": ["T038"], "canonical_name": "regulation of respiratory burst involved in inflammatory response", "definition": "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]"}
{"concept_id": "C3155582", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of respiratory burst involved in inflammatory response", "definition": "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C3155583", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of respiratory burst involved in inflammatory response", "definition": "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C3155584", "aliases": [], "types": ["T043"], "canonical_name": "regulation of SMAD protein signal transduction", "definition": "Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C3155586", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic anaphase-promoting complex activity"}
{"concept_id": "C3155587", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of anaphase-promoting complex activity during mitotic cell cycle"}
{"concept_id": "C3155588", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of APC/C activity during mitotic cell cycle"}
{"concept_id": "C3155589", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cyclosome activity during mitotic cell cycle"}
{"concept_id": "C3155595", "aliases": ["regulation of ascospore wall 1,3-beta-D-glucan biosynthetic process"], "types": ["T043"], "canonical_name": "regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process", "definition": "Any process that modulates the rate, frequency, or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D--glucosidic bonds, found in the walls of ascospores. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155596", "aliases": ["positive regulation of 1,3-beta-D-glucan biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of (1->3)-beta-D-glucan biosynthetic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155597", "aliases": ["negative regulation of 1,3-beta-D-glucan biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of (1->3)-beta-D-glucan biosynthetic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155603", "aliases": ["extrahepatic bile duct development"], "types": ["T042"], "canonical_name": "EHBD development"}
{"concept_id": "C3155604", "aliases": [], "types": ["T044"], "canonical_name": "chaperone-mediated protein folding", "definition": "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155605", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of prostaglandin secretion involved in immune response", "definition": "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell and contributes to the immune response. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155606", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of prostaglandin secretion during immune response"}
{"concept_id": "C3155607", "aliases": [], "types": ["T042"], "canonical_name": "left horn of sinus venosus development", "definition": "The progression of the left horn of the sinus venosus from its initial formation to the mature structure. [GOC:dph]"}
{"concept_id": "C3155608", "aliases": [], "types": ["T042"], "canonical_name": "right horn of sinus venosus development", "definition": "The progression of the right horn of the sinus venosus from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C3155609", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of myeloid leukocyte cytokine production involved in immune response", "definition": "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155610", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of myeloid cell cytokine production involved in immune response"}
{"concept_id": "C3155611", "aliases": [], "types": ["T040"], "canonical_name": "myeloid leukocyte cytokine production", "definition": "Any process that contributes to cytokine production by a myeloid cell. [GOC:dph]"}
{"concept_id": "C3155612", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein refolding", "definition": "Any process that regulates the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155613", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein refolding", "definition": "Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C3155614", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H3-K27 methylation", "definition": "Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155615", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K27 methylation", "definition": "Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155616", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K27 methylation", "definition": "Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155617", "aliases": [], "types": ["T039"], "canonical_name": "regulation of sequestering of zinc ion", "definition": "Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C3155618", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of sequestering of zinc ion", "definition": "Any process that decreases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C3155619", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of sequestering of zinc ion", "definition": "Any process that increases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C3155620", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phospholipid translocation", "definition": "Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]"}
{"concept_id": "C3155621", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phospholipid translocation", "definition": "Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]"}
{"concept_id": "C3155622", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phospholipid translocation", "definition": "Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]"}
{"concept_id": "C3155623", "aliases": [], "types": ["T038"], "canonical_name": "regulation of turning behavior involved in mating", "definition": "Any process that modulates the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155624", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of turning behavior involved in mating", "definition": "Any process that increases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155625", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of turning behavior involved in mating", "definition": "Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155626", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein tyrosine kinase activity", "definition": "Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155627", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein tyrosine kinase activity", "definition": "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155628", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of protein tyrosine kinase activity", "definition": "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155629", "aliases": [], "types": ["T043"], "canonical_name": "lung neuroendocrine cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. [GOC:dph, PMID:9126746]"}
{"concept_id": "C3155630", "aliases": [], "types": ["T043"], "canonical_name": "neuroendocrine cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. [GOC:dph]"}
{"concept_id": "C3155631", "aliases": [], "types": ["T043"], "canonical_name": "stomach neuroendocrine cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. [GOC:dph, PMID:18173746]"}
{"concept_id": "C3155632", "aliases": [], "types": ["T043"], "canonical_name": "gastric neuroendocrine cell differentiation"}
{"concept_id": "C3155633", "aliases": [], "types": ["T043"], "canonical_name": "carotid body glomus cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia. [GOC:dph, PMID:6243386]"}
{"concept_id": "C3155634", "aliases": [], "types": ["T043"], "canonical_name": "adrenal chromaffin cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles. [GOC:dph]"}
{"concept_id": "C3155635", "aliases": [], "types": ["T043"], "canonical_name": "regulation of stomach neuroendocrine cell differentiation", "definition": "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. [GOC:dph]"}
{"concept_id": "C3155636", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of stomach neuroendocrine cell differentiation", "definition": "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. [GOC:dph]"}
{"concept_id": "C3155637", "aliases": [], "types": ["T040"], "canonical_name": "seminal vesicle development", "definition": "The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen. [GOC:dph]"}
{"concept_id": "C3155638", "aliases": [], "types": ["T042"], "canonical_name": "seminal vesicle epithelium development", "definition": "The progression of the seminal vesicle epithelium over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C3155639", "aliases": ["dense core granule organisation"], "types": ["T043"], "canonical_name": "dense core granule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. [GOC:dph]"}
{"concept_id": "C3155640", "aliases": [], "types": ["T043"], "canonical_name": "dense core granule biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a dense core granule. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the dense core granule. [GOC:dph]"}
{"concept_id": "C3155641", "aliases": ["epithelial-mesenchymal cell signalling involved in lung development"], "types": ["T043"], "canonical_name": "epithelial-mesenchymal cell signaling involved in lung development", "definition": "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ. [GOC:dph]"}
{"concept_id": "C3155642", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of bud outgrowth involved in lung branching", "definition": "Any process that decreases the rate, frequency, or extent of bud outgrowth involved in lung branching. [GOC:dph]"}
{"concept_id": "C3155643", "aliases": [], "types": ["T042"], "canonical_name": "pancreas morphogenesis", "definition": "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. [GOC:dph]"}
{"concept_id": "C3155644", "aliases": [], "types": ["T042"], "canonical_name": "branching involved in pancreas morphogenesis", "definition": "The process in which the branches of the pancreas are generated and organized. [GOC:dph]"}
{"concept_id": "C3155645", "aliases": [], "types": ["T042"], "canonical_name": "lung proximal/distal axis specification", "definition": "The establishment, maintenance and elaboration of the proximal/distal axis of the lung. The proximal/distal axis of the lung is defined by a line that runs from the trachea to the alveoli. [GOC:dph]"}
{"concept_id": "C3155646", "aliases": [], "types": ["T042"], "canonical_name": "ductus venosus closure", "definition": "The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth. [GOC:dph]"}
{"concept_id": "C3155647", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of heart growth", "definition": "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. [GOC:dph, GOC:hjd]"}
{"concept_id": "C3155648", "aliases": [], "types": ["T043"], "canonical_name": "regulation of positive chemotaxis to cAMP", "definition": "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP. [GOC:dph]"}
{"concept_id": "C3155649", "aliases": [], "types": ["T043"], "canonical_name": "regulation of positive chemotaxis to cAMP by chlorinated alkylphenone", "definition": "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions. [GOC:dph, PMID:19684855]"}
{"concept_id": "C3155650", "aliases": [], "types": ["T043"], "canonical_name": "regulation of positive chemotaxis to cAMP by DIF-1", "definition": "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone. [GOC:dph]"}
{"concept_id": "C3155651", "aliases": [], "types": ["T043"], "canonical_name": "regulation of positive chemotaxis to cAMP by DIF-2", "definition": "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone. [GOC:dph]"}
{"concept_id": "C3155652", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of positive chemotaxis to cAMP", "definition": "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP. [GOC:dph]"}
{"concept_id": "C3155653", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of positive chemotaxis to cAMP", "definition": "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP. [GOC:dph]"}
{"concept_id": "C3155654", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone", "definition": "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions. [GOC:dph]"}
{"concept_id": "C3155655", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone", "definition": "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions. [GOC:dph]"}
{"concept_id": "C3155656", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of positive chemotaxis to cAMP by DIF-1", "definition": "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone. [GOC:dph]"}
{"concept_id": "C3155657", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of positive chemotaxis to cAMP by DIF-1", "definition": "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone. [GOC:dph]"}
{"concept_id": "C3155658", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of chemotaxis to cAMP by DIF-2", "definition": "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone. [GOC:dph]"}
{"concept_id": "C3155659", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of positive chemotaxis to cAMP by DIF-2", "definition": "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone. [GOC:dph]"}
{"concept_id": "C3155660", "aliases": [], "types": ["T042"], "canonical_name": "pancreatic bud formation", "definition": "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. [GOC:dph]"}
{"concept_id": "C3155661", "aliases": [], "types": ["T042"], "canonical_name": "pancreas field specification", "definition": "The process in which a specific region of the gut is delineated into the area in which the pancreas will develop. [GOC:dph]"}
{"concept_id": "C3155662", "aliases": [], "types": ["T038"], "canonical_name": "pancreas induction", "definition": "The close range interaction of two or more cells or tissues that causes the cells of the gut to change their fates and specify the development of the pancreas. [GOC:dph]"}
{"concept_id": "C3155663", "aliases": [], "types": ["T044"], "canonical_name": "endopeptidase activator activity", "definition": "Binds to and increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155664", "aliases": [], "types": ["T044"], "canonical_name": "endopeptidase regulator activity", "definition": "Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155665", "aliases": [], "types": ["T044"], "canonical_name": "regulation of proteasomal protein catabolic process", "definition": "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. [GOC:dph, GOC:tb]"}
{"concept_id": "C3155666", "aliases": [], "types": ["T040"], "canonical_name": "bud dilation", "definition": "The process in which a branch bud increases radially. A branch bud is the initial area of outgrowth in the formation of a new branch. [GOC:dph]"}
{"concept_id": "C3155667", "aliases": [], "types": ["T040"], "canonical_name": "morphogenesis of a branching epithelium", "definition": "The process in which the anatomical structures of a branched epithelium are generated and organized. [GOC:dph]"}
{"concept_id": "C3155668", "aliases": [], "types": ["T042"], "canonical_name": "bud field specification", "definition": "The regionalization process in which the identity of a bud primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:dph]"}
{"concept_id": "C3155669", "aliases": [], "types": ["T043"], "canonical_name": "lung secretory cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. [GOC:dph]"}
{"concept_id": "C3155670", "aliases": [], "types": ["T043"], "canonical_name": "lung ciliated cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. [GOC:cilia, GOC:dph, GOC:krc]"}
{"concept_id": "C3155671", "aliases": ["mesothelial-mesenchymal cell signalling involved in early lung development"], "types": ["T043"], "canonical_name": "mesothelial-mesenchymal cell signaling involved in early lung development", "definition": "Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung. [GOC:dph]"}
{"concept_id": "C3155672", "aliases": [], "types": ["T042"], "canonical_name": "alveolar primary septum development", "definition": "The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms. [GOC:dph]"}
{"concept_id": "C3155673", "aliases": [], "types": ["T042"], "canonical_name": "alveolar secondary septum development", "definition": "The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule. [GOC:dph]"}
{"concept_id": "C3155674", "aliases": [], "types": ["T042"], "canonical_name": "lung smooth muscle development", "definition": "The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C3155675", "aliases": [], "types": ["T040"], "canonical_name": "Peyer's patch morphogenesis", "definition": "The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes. [GOC:dph]"}
{"concept_id": "C3155676", "aliases": [], "types": ["T042"], "canonical_name": "endocardial endothelium development", "definition": "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:dph]"}
{"concept_id": "C3155677", "aliases": ["extracellular matrix organisation involved in endocardium development"], "types": ["T043"], "canonical_name": "extracellular matrix organization involved in endocardium development", "definition": "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:dph]"}
{"concept_id": "C3155678", "aliases": ["BMP signalling pathway involved in ureter morphogenesis"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in ureter morphogenesis", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155679", "aliases": ["urinary tract segmentation"], "types": ["T038"], "canonical_name": "renal system segmentation", "definition": "The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155680", "aliases": ["BMP signalling pathway involved in renal system segmentation"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in renal system segmentation", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the segmentation of the renal system. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155681", "aliases": [], "types": ["T042"], "canonical_name": "trachea submucosa development", "definition": "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155682", "aliases": [], "types": ["T042"], "canonical_name": "trachea gland development", "definition": "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection. [GOC:dph]"}
{"concept_id": "C3155683", "aliases": [], "types": ["T042"], "canonical_name": "endothelial tube morphogenesis", "definition": "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155684", "aliases": [], "types": ["T042"], "canonical_name": "pulmonary artery endothelial tube morphogenesis", "definition": "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155685", "aliases": [], "types": ["T042"], "canonical_name": "pulmonary artery morphogenesis", "definition": "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155686", "aliases": [], "types": ["T045"], "canonical_name": "mRNA destabilization", "definition": "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns. [GOC:dph, GOC:jh]"}
{"concept_id": "C3155687", "aliases": [], "types": ["T045"], "canonical_name": "3'-UTR-mediated mRNA destabilization", "definition": "An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. [GOC:dph, GOC:jh]"}
{"concept_id": "C3155688", "aliases": [], "types": ["T043"], "canonical_name": "establishment of bipolar cell polarity involved in cell morphogenesis", "definition": "The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155689", "aliases": [], "types": ["T039"], "canonical_name": "regulation of establishment of bipolar cell polarity regulating cell shape", "definition": "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155690", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of establishment of bipolar cell polarity regulating cell shape", "definition": "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155691", "aliases": [], "types": ["T043"], "canonical_name": "establishment of monopolar cell polarity", "definition": "The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155692", "aliases": ["ER polarization"], "types": ["T043"], "canonical_name": "endoplasmic reticulum polarization", "definition": "The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell. Endoplasmic reticulum polarization serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155697", "aliases": [], "types": ["T038"], "canonical_name": "regulation of hair follicle placode formation", "definition": "Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. [GOC:dph]"}
{"concept_id": "C3155698", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of hair placode formation", "definition": "Any process that increases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. [GOC:dph]"}
{"concept_id": "C3155699", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of hair follicle placode formation", "definition": "Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. [GOC:dph]"}
{"concept_id": "C3155700", "aliases": [], "types": ["T043"], "canonical_name": "establishment of bipolar cell polarity", "definition": "The specification and formation of bipolar intracellular organization or cell growth patterns. Bipolar organization is the organization that is a mirror image along an axis from a plane. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155701", "aliases": [], "types": ["T039"], "canonical_name": "regulation of establishment of bipolar cell polarity", "definition": "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155702", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of establishment of bipolar cell polarity", "definition": "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155703", "aliases": ["type I terminal button"], "types": ["T026"], "canonical_name": "type I terminal bouton", "definition": "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. [GOC:dph, GOC:mc]"}
{"concept_id": "C3155704", "aliases": ["type II terminal button"], "types": ["T026"], "canonical_name": "type II terminal bouton", "definition": "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. [GOC:dph, GOC:mc]"}
{"concept_id": "C3155705", "aliases": ["type Ib terminal button"], "types": ["T026"], "canonical_name": "type Ib terminal bouton", "definition": "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons. [GOC:dph, GOC:mc]"}
{"concept_id": "C3155706", "aliases": [], "types": ["T026"], "canonical_name": "type Is terminal button"}
{"concept_id": "C3155707", "aliases": [], "types": ["T026"], "canonical_name": "type Is terminal bouton", "definition": "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons. [GOC:dph, GOC:mc]"}
{"concept_id": "C3155708", "aliases": ["regulation of insulin secretion in response to glucose"], "types": ["T039"], "canonical_name": "regulation of insulin secretion involved in cellular response to glucose stimulus", "definition": "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155709", "aliases": ["negative regulation of insulin secretion involved in cellular response to glucose"], "types": ["T043"], "canonical_name": "negative regulation of insulin secretion involved in cellular response to glucose stimulus", "definition": "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155710", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of insulin secretion in response to glucose"}
{"concept_id": "C3155711", "aliases": ["breast epithelium development"], "types": ["T042"], "canonical_name": "mammary gland epithelium development", "definition": "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155712", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chondrocyte development", "definition": "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155713", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of chondrocyte development", "definition": "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155714", "aliases": [], "types": ["T040"], "canonical_name": "regulation of dermatome development", "definition": "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155715", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of dermatome development", "definition": "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155716", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of dermatome development", "definition": "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155717", "aliases": ["negative regulation of chromatin silencing at silent mating-type cassette"], "types": ["T045"], "canonical_name": "negative regulation of silent mating-type cassette heterochromatin assembly", "definition": "Any process that decreases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin. [GOC:dph, PMID:10388812]"}
{"concept_id": "C3155718", "aliases": [], "types": ["T045"], "canonical_name": "regulation of chromatin silencing at rDNA"}
{"concept_id": "C3155719", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of chromatin silencing at rDNA"}
{"concept_id": "C3155720", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of sclerotome development", "definition": "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155721", "aliases": [], "types": ["T040"], "canonical_name": "regulation of sclerotome development", "definition": "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. [GOC:dph]"}
{"concept_id": "C3155722", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of vacuole fusion, non-autophagic", "definition": "Any process that increases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole. [GOC:dph]"}
{"concept_id": "C3155723", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of vacuole fusion, non-autophagic", "definition": "Any process that decreases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole. [GOC:dph]"}
{"concept_id": "C3155724", "aliases": [], "types": ["T042"], "canonical_name": "taste bud development", "definition": "The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors. [GOC:dph]"}
{"concept_id": "C3155725", "aliases": [], "types": ["T040"], "canonical_name": "taste bud morphogenesis", "definition": "The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors. [GOC:dph]"}
{"concept_id": "C3155726", "aliases": [], "types": ["T042"], "canonical_name": "taste bud formation", "definition": "The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors. [GOC:dph]"}
{"concept_id": "C3155727", "aliases": [], "types": ["T042"], "canonical_name": "fungiform papilla development", "definition": "The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue. [GOC:dph]"}
{"concept_id": "C3155728", "aliases": [], "types": ["T040"], "canonical_name": "fungiform papilla morphogenesis", "definition": "The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue. [GOC:dph]"}
{"concept_id": "C3155729", "aliases": [], "types": ["T042"], "canonical_name": "fungiform papilla formation", "definition": "The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue. [GOC:dph]"}
{"concept_id": "C3155730", "aliases": [], "types": ["T042"], "canonical_name": "striated muscle contraction involved in embryonic body morphogenesis", "definition": "The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology. [GOC:dph, GOC:kmv]"}
{"concept_id": "C3155731", "aliases": ["clathrin sculpted GABA transport vesicle", "clathrin sculpted gamma-aminobutyric acid transport vesicle"], "types": ["T026"], "canonical_name": "clathrin-sculpted gamma-aminobutyric acid transport vesicle", "definition": "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle. [GOC:dph]"}
{"concept_id": "C3155732", "aliases": ["clathrin sculpted gamma-aminobutyric acid transport vesicle lumen", "clathrin sculpted GABA transport vesicle lumen"], "types": ["T026"], "canonical_name": "clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen", "definition": "The volume enclosed by the membrane of the clathrin-sculpted gamma-aminobutyric acid transport vesicle. [GOC:dph]"}
{"concept_id": "C3155733", "aliases": ["clathrin sculpted gamma-aminobutyric acid transport vesicle membrane", "clathrin sculpted GABA transport vesicle membrane"], "types": ["T026"], "canonical_name": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "definition": "The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle. [GOC:dph]"}
{"concept_id": "C3155734", "aliases": [], "types": ["T043"], "canonical_name": "striated muscle paramyosin thick filament assembly", "definition": "The aggregation, arrangement and bonding together of proteins to form the paramyosin-based thick filaments of myofibrils in striated muscle. [GOC:dph, GOC:kmv]"}
{"concept_id": "C3155735", "aliases": [], "types": ["T043"], "canonical_name": "paramyosin filament assembly or disassembly", "definition": "The formation or disassembly of a filament composed of paramyosin molecules. [GOC:dph, GOC:kmv]"}
{"concept_id": "C3155736", "aliases": ["Mullerian duct development"], "types": ["T042"], "canonical_name": "paramesonephric duct development", "definition": "The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155737", "aliases": ["Wolffian body morphogenesis"], "types": ["T042"], "canonical_name": "mesonephros morphogenesis", "definition": "The process in which the anatomical structures of the mesonephros are generated and organized. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155738", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric juxtaglomerulus cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the mesonephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155739", "aliases": [], "types": ["T043"], "canonical_name": "cell differentiation involved in mesonephros development", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155740", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in mesonephros development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155741", "aliases": ["cell-cell signalling involved in mesonephros development"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in mesonephros development", "definition": "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155742", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric collecting duct development", "definition": "The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155743", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric juxtaglomerular apparatus development", "definition": "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155744", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of mesonephros development", "definition": "Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155745", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric smooth muscle tissue development", "definition": "The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155746", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric nephron development", "definition": "The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155748", "aliases": [], "types": ["T042"], "canonical_name": "regulation of mesonephros development", "definition": "Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155749", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of mesonephros development", "definition": "Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155750", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric mesenchyme development", "definition": "The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155751", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric macula densa development", "definition": "The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155752", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric mesenchyme morphogenesis", "definition": "The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155753", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric mesenchymal cell proliferation involved in mesonephros development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a mesonephric mesenchymal cell population. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155754", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric mesenchymal cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155755", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric glomerulus development", "definition": "The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155756", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development", "definition": "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155757", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric Goormaghtigh proliferation"}
{"concept_id": "C3155758", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric lacis cell proliferation"}
{"concept_id": "C3155759", "aliases": [], "types": ["T042"], "canonical_name": "proximal/distal pattern formation involved in mesonephric nephron development", "definition": "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the mesonephros. The proximal/distal axis is defined by a line that runs from the glomerulus (proximal end) outward toward the mesonephric duct (distal end). [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155760", "aliases": ["mesonephros pattern specification"], "types": ["T042"], "canonical_name": "pattern specification involved in mesonephros development", "definition": "Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155761", "aliases": [], "types": ["T042"], "canonical_name": "mesonephros pattern formation"}
{"concept_id": "C3155762", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric nephron morphogenesis", "definition": "The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155763", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric juxtaglomerulus cell development", "definition": "The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155764", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric juxtaglomerulus cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric juxtaglomerulus cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155765", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric glomerulus vasculature development", "definition": "The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155766", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric glomerular epithelium development", "definition": "The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155767", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular basement membrane development", "definition": "The process whose specific outcome is the progression of the mesonephric glomerular basement membrane over time, from its formation to the mature structure. The mesonephric glomerular basement membrane is the basal laminal portion of the mesonephric glomerulus which performs the actual filtration. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155768", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric glomerulus morphogenesis", "definition": "The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155769", "aliases": [], "types": ["T040"], "canonical_name": "mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis", "definition": "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155770", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric comma-shaped body morphogenesis", "definition": "The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155771", "aliases": [], "types": ["T042"], "canonical_name": "convergent extension involved in mesonephric nephron morphogenesis", "definition": "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155772", "aliases": [], "types": ["T042"], "canonical_name": "establishment of planar polarity involved in mesonephric nephron morphogenesis", "definition": "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155773", "aliases": [], "types": ["T042"], "canonical_name": "establishment of planar cell polarity involved in mesonephric nephron morphogenesis"}
{"concept_id": "C3155774", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155775", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric nephron tubule morphogenesis", "definition": "The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155776", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric nephron epithelium development", "definition": "The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155777", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric nephron tubule development", "definition": "The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155778", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric renal vesicle morphogenesis", "definition": "The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155779", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric S-shaped body morphogenesis", "definition": "The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155780", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of bipolar cell polarity", "definition": "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155781", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of bipolar cell polarity regulating cell shape", "definition": "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155782", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric glomerular mesangium development", "definition": "The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155783", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric glomerulus vasculature morphogenesis", "definition": "The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155784", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric glomerular capillary formation", "definition": "The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155785", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155786", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular epithelial cell development", "definition": "The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155787", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular epithelial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155788", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular parietal epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155789", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular parietal epithelial cell development", "definition": "The process whose specific outcome is the progression of a mesonephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155790", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular parietal epithelial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155791", "aliases": ["mesonephric glomerular visceral epithelial cell differentiation"], "types": ["T043"], "canonical_name": "mesonephric podocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155792", "aliases": ["mesonephric glomerular visceral epithelial cell development"], "types": ["T043"], "canonical_name": "mesonephric podocyte development", "definition": "The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155793", "aliases": ["mesonephric glomerular visceral epithelial cell fate commitment"], "types": ["T043"], "canonical_name": "mesonephric podocyte cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155794", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric glomerular mesangial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the mesonephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155795", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric mesangial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the mesonephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155796", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal to epithelial transition involved in mesonephros morphogenesis", "definition": "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155797", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric mesenchyme to epithelial transition"}
{"concept_id": "C3155798", "aliases": ["mesonephros formation"], "types": ["T042"], "canonical_name": "mesonephric renal vesicle formation", "definition": "The developmental process pertaining to the initial formation of the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155799", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular mesangial cell development", "definition": "The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155800", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular mesangial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155801", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric nephron tubule epithelial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155802", "aliases": ["mesonephros interstitial cell differentiation"], "types": ["T043"], "canonical_name": "mesonephric interstitial fibroblast differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the mesonephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155803", "aliases": ["mesonephros interstitial cell development"], "types": ["T043"], "canonical_name": "mesonephric interstitial fibroblast development", "definition": "The process whose specific outcome is the progression of a mesonephric interstitial fibroblast over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155804", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric interstitial fibroblast fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric interstitial fibroblast. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155805", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric glomerular mesangial cell proliferation involved in mesonephros development", "definition": "The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155806", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric intraglomerular mesangial cell proliferation", "definition": "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155807", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal to epithelial transition involved in mesonephric renal vesicle formation", "definition": "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155808", "aliases": ["mesonephric connecting duct development", "mesonephric collecting tubule development"], "types": ["T042"], "canonical_name": "mesonephric connecting tubule development", "definition": "The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155809", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric distal tubule morphogenesis", "definition": "The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155810", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric distal tubule development", "definition": "The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155811", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric proximal tubule development", "definition": "The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155812", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric proximal tubule morphogenesis", "definition": "The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155813", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric nephron tubule formation", "definition": "The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155814", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration involved in mesonephric nephron tubule morphogenesis", "definition": "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric nephron tubule morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155815", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration involved in mesonephric distal tubule morphogenesis", "definition": "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric distal tubule morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155816", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration involved in mesonephric proximal tubule morphogenesis", "definition": "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric proximal tubule morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155817", "aliases": ["specification of mesonephric collecting tubule identity"], "types": ["T042"], "canonical_name": "specification of mesonephric connecting tubule identity", "definition": "The process in which the connecting tubule of the mesonephric nephron acquires its identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155818", "aliases": [], "types": ["T042"], "canonical_name": "specification of mesonephric nephron tubule identity", "definition": "The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155819", "aliases": [], "types": ["T042"], "canonical_name": "specification of mesonephric distal tubule identity", "definition": "The process in which the distal tubule of the mesonephric nephron acquires its identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155820", "aliases": [], "types": ["T042"], "canonical_name": "specification of mesonephric proximal tubule identity", "definition": "The process in which the proximal tubule of the mesonephric nephron acquires its identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155821", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric capsule development", "definition": "The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155822", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric capsule morphogenesis", "definition": "The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155823", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric capsule formation", "definition": "The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155824", "aliases": [], "types": ["T042"], "canonical_name": "mesonephric capsule specification", "definition": "The regionalization process in which the identity of the mesonephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155825", "aliases": ["Wnt-activated signaling pathway involved in kidney development", "Wnt receptor signaling pathway involved in kidney development", "Wnt receptor signalling pathway involved in kidney development"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in kidney development", "definition": "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the kidney over time. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155826", "aliases": ["canonical Wnt receptor signalling pathway involved in metanephric kidney development", "canonical Wnt-activated signaling pathway involved in metanephric kidney development", "canonical Wnt receptor signaling pathway involved in metanephric kidney development"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in metanephric kidney development", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155827", "aliases": ["canonical Wnt receptor signaling pathway involved in ureteric bud branching", "canonical Wnt receptor signalling pathway involved in ureteric bud branching"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in ureteric bud branching", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155828", "aliases": ["canonical Wnt-activated signaling pathway involved in mesonephros development", "canonical Wnt receptor signalling pathway involved in mesonephros development", "canonical Wnt receptor signaling pathway involved in mesonephros development"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in mesonephros development", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the mesonephros over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155829", "aliases": ["canonical Wnt receptor signalling pathway involved in mesonephric nephron development", "canonical Wnt receptor signaling pathway involved in mesonephric nephron development", "canonical Wnt-activated signaling pathway involved in mesonephric nephron development"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in mesonephric nephron development", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the mesonephric nephron over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155830", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric renal vesicle induction", "definition": "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the mesonephric renal vesicle. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155831", "aliases": ["regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis", "regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis"], "types": ["T038"], "canonical_name": "regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis", "definition": "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155832", "aliases": ["negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis", "negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis"], "types": ["T038"], "canonical_name": "negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis", "definition": "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155833", "aliases": ["positive regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis", "positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis"], "types": ["T038"], "canonical_name": "positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis", "definition": "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155834", "aliases": ["retinal vasculature development"], "types": ["T042"], "canonical_name": "retina vasculature development in camera-type eye", "definition": "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155835", "aliases": ["retinal vasculature morphogenesis"], "types": ["T040"], "canonical_name": "retina vasculature morphogenesis in camera-type eye", "definition": "The process in which the vasculature of the retina is generated and organized. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155836", "aliases": [], "types": ["T042"], "canonical_name": "cerebellum vasculature development", "definition": "The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C3155837", "aliases": [], "types": ["T040"], "canonical_name": "cerebellum vasculature morphogenesis", "definition": "The process in which the vasculature of the cerebellum is generated and organized. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155838", "aliases": [], "types": ["T026"], "canonical_name": "smooth muscle cell-matrix adhesion", "definition": "The binding of a smooth muscle cell to the extracellular matrix via adhesion molecules. [GOC:BHF, GOC:dph, PMID:8837777]"}
{"concept_id": "C3155839", "aliases": [], "types": ["T042"], "canonical_name": "cornea development in camera-type eye", "definition": "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. [GOC:dph]"}
{"concept_id": "C3155840", "aliases": [], "types": ["T042"], "canonical_name": "retinal blood vessel morphogenesis", "definition": "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155841", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of bipolar cell polarity regulating cell shape", "definition": "The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155843", "aliases": [], "types": ["T043"], "canonical_name": "cardiac neural crest cell differentiation involved in heart development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. [GOC:dph, GOC:mtg_heart, PMID:19705442]"}
{"concept_id": "C3155844", "aliases": [], "types": ["T043"], "canonical_name": "cardiac neural crest cell development involved in heart development", "definition": "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C3155845", "aliases": [], "types": ["T043"], "canonical_name": "cardiac neural crest cell development involved in outflow tract morphogenesis", "definition": "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C3155846", "aliases": ["canonical Wnt receptor signalling pathway involved in cardiac neural crest cell differentiation involved in heart development", "canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development", "canonical Wnt-activated signaling pathway involved in cardiac neural crest cell differentiation involved in heart development"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in cardiac neural crest cell differentiation. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C3155847", "aliases": ["cell surface receptor linked signaling pathway involved in heart development", "cell surface receptor linked signalling pathway involved in heart development"], "types": ["T044"], "canonical_name": "cell surface receptor signaling pathway involved in heart development", "definition": "The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time. [GOC:dph, GOC:mtg_heart, GOC:signaling]"}
{"concept_id": "C3155848", "aliases": ["BMP signalling pathway involved in heart development"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in heart development", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the progression of the heart over time. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C3155849", "aliases": ["fibroblast growth factor receptor signalling pathway involved in heart development"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in heart development", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands and contributing to the progression of the heart over time. [GOC:mtg_heart]"}
{"concept_id": "C3155850", "aliases": ["Notch signalling involved in heart development"], "types": ["T044"], "canonical_name": "Notch signaling involved in heart development", "definition": "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time. [GOC:mtg_heart]"}
{"concept_id": "C3155851", "aliases": ["canonical Wnt-activated signaling pathway involved in positive regulation of cardiac muscle cell proliferation", "canonical Wnt receptor signaling pathway involved in positive regulation of cardiac muscle cell proliferation", "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac muscle cell proliferation"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation", "definition": "The canonical Wnt signaling pathway that contributes to an expansion of the population of cardiac muscle cells. [GOC:mtg_heart]"}
{"concept_id": "C3155852", "aliases": ["canonical Wnt receptor signalling pathway involved in heart development", "canonical Wnt receptor signaling pathway involved in heart development", "canonical Wnt-activated signaling pathway involved in heart development"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in heart development", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [GOC:mtg_heart]"}
{"concept_id": "C3155853", "aliases": ["canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [GOC:mtg_heart, PMID:17576928]"}
{"concept_id": "C3155854", "aliases": [], "types": ["T043"], "canonical_name": "renal filtration cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155855", "aliases": [], "types": ["T043"], "canonical_name": "nephrocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [CL:0002520, GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C3155856", "aliases": [], "types": ["T043"], "canonical_name": "pericardial nephrocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]"}
{"concept_id": "C3155857", "aliases": ["garland cell differentiation"], "types": ["T043"], "canonical_name": "garland nephrocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]"}
{"concept_id": "C3155858", "aliases": [], "types": ["T043"], "canonical_name": "disseminated nephrocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [CL:0002524, GOC:19783135, GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155859", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in heart morphogenesis", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C3155860", "aliases": ["canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation", "canonical Wnt-activated signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation", "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac outflow tract cell proliferation"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation", "definition": "The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C3155861", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in outflow tract morphogenesis", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C3155862", "aliases": [], "types": ["T039"], "canonical_name": "renal tubule development", "definition": "The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155863", "aliases": [], "types": ["T038"], "canonical_name": "anterior Malpighian tubule development", "definition": "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut. [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C3155864", "aliases": [], "types": ["T038"], "canonical_name": "posterior Malpighian tubule development", "definition": "The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155865", "aliases": [], "types": ["T043"], "canonical_name": "Malpighian tubule principal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule. [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C3155866", "aliases": [], "types": ["T043"], "canonical_name": "Malpighian tubule stellate cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium. [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C3155867", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell proliferation involved in Malpighian tubule morphogenesis", "definition": "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule. [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C3155868", "aliases": ["Malpighian tubule formation"], "types": ["T042"], "canonical_name": "Malpighian tubule bud morphogenesis", "definition": "The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position. [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C3155869", "aliases": [], "types": ["T042"], "canonical_name": "renal tubule morphogenesis", "definition": "The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155870", "aliases": ["cell migration involved in Malpighian tubule morphogenesis"], "types": ["T043"], "canonical_name": "cell rearrangement involved in Malpighian tubule morphogenesis", "definition": "The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155871", "aliases": [], "types": ["T043"], "canonical_name": "cell growth involved in Malpighian tubule morphogenesis", "definition": "The growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule. [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C3155872", "aliases": [], "types": ["T043"], "canonical_name": "cell morphogenesis involved in Malpighian tubule morphogenesis", "definition": "The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule. [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C3155874", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of monopolar cell polarity", "definition": "Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155875", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of monopolar cell polarity regulating cell shape", "definition": "Any cellular process that results in the specification, formation or maintenance of a monopolar intracellular organization or cell growth patterns that regulate the shape of a cell. [GOC:dph, GOC:vw]"}
{"concept_id": "C3155876", "aliases": ["non-canonical Wnt receptor signaling pathway involved in heart development", "non-canonical Wnt-activated signaling pathway involved in heart development", "non-canonical Wnt receptor signalling pathway involved in heart development"], "types": ["T044"], "canonical_name": "non-canonical Wnt signaling pathway involved in heart development", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time. [GOC:dph, GOC:mtg_heart, PMID:16860783]"}
{"concept_id": "C3155877", "aliases": ["regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway"], "types": ["T044"], "canonical_name": "regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway", "definition": "Any process that decreased the extent of cell adhesion that contributes to the shaping of the heart. [PMID:16860783]"}
{"concept_id": "C3155878", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in heart morphogenesis", "definition": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart. [GOC:dph, GOC:mtg_heart, PMID:16860783]"}
{"concept_id": "C3155879", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell adhesion involved in heart morphogenesis", "definition": "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart. [GOC:dph, GOC:mtg_heart, PMID:16860783]"}
{"concept_id": "C3155880", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in cardiac muscle cell fate commitment", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to a cardioblast being committed to a cardiac muscle cell fate. [GOC:dph, GOC:mtg_heart, PMID:16860783]"}
{"concept_id": "C3155881", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in heart morphogenesis", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart. [GOC:dph, GOC:mtg_heart, PMID:16860783]"}
{"concept_id": "C3155882", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in outflow tract morphogenesis", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract. [GOC:dph, GOC:mtg_heart, PMID:19056682]"}
{"concept_id": "C3155883", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in ventricular septum morphogenesis", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum. [GOC:dph, GOC:mtg_heart, PMID:19056682]"}
{"concept_id": "C3155884", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in cardiac right atrium morphogenesis", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium. [GOC:dph, GOC:mtg_heart, PMID:19056682]"}
{"concept_id": "C3155885", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in cardiac muscle tissue morphogenesis", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue. [GOC:dph, GOC:mtg_heart, PMID:19056682]"}
{"concept_id": "C3155886", "aliases": [], "types": ["T043"], "canonical_name": "neural precursor cell proliferation", "definition": "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155887", "aliases": [], "types": ["T043"], "canonical_name": "cell chemotaxis involved in Malpighian tubule morphogenesis", "definition": "The directed movement of the outgrowing Malpighian tubule guided by specific chemical cues/signals. Movement may be towards a guidance cue (positive chemotaxis) or away from it (negative chemotaxis). Guidance contributes to the final positioning of the tubule. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3155888", "aliases": ["bone morphogenic protein receptor signalling pathway involved in Malpighian tubule cell chemotaxis"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in Malpighian tubule cell chemotaxis", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule. [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]"}
{"concept_id": "C3155889", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in pericardium morphogenesis", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium. [GOC:dph, GOC:mtg_heart, PMID:19056682]"}
{"concept_id": "C3155890", "aliases": [], "types": ["T043"], "canonical_name": "Wnt protein secretion", "definition": "The controlled release of a Wnt protein from a cell. [GOC:bf, PMID:19223472]"}
{"concept_id": "C3155891", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Wnt protein secretion", "definition": "Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell. [GOC:bf, PMID:19223472]"}
{"concept_id": "C3155892", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt protein secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell. [GOC:bf, PMID:19223472]"}
{"concept_id": "C3155893", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Wnt protein secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell. [GOC:bf, PMID:19223472]"}
{"concept_id": "C3155894", "aliases": ["regulation of Wnt receptor signaling pathway by Wnt protein secretion", "regulation of Wnt receptor signalling pathway by Wnt protein secretion", "regulation of Wnt-activated signaling pathway by Wnt protein secretion"], "types": ["T044"], "canonical_name": "regulation of Wnt signaling pathway by Wnt protein secretion", "definition": "Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell. [GOC:bf, GOC:jl, PMID:19223472]"}
{"concept_id": "C3155895", "aliases": ["optic chiasm development"], "types": ["T042"], "canonical_name": "optic chiasma development", "definition": "The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature. [GOC:dph]"}
{"concept_id": "C3155896", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of maintenance of bipolar cell polarity regulating cell shape", "definition": "Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape. [GOC:dph]"}
{"concept_id": "C3155897", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of maintenance of bipolar cell polarity regulating cell shape", "definition": "Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape. [GOC:dph]"}
{"concept_id": "C3155898", "aliases": ["functional luteolysis"], "types": ["T044"], "canonical_name": "negative regulation of progesterone biosynthesis involved in luteolysis", "definition": "Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis. [GOC:dph]"}
{"concept_id": "C3155899", "aliases": ["structural luteolysis"], "types": ["T043"], "canonical_name": "apoptotic process involved in luteolysis", "definition": "The apoptotic process that contributes to luteolysis. [GOC:mtg_apoptosis, PMID:18566128]"}
{"concept_id": "C3155900", "aliases": ["positive regulation of TAG activity"], "types": ["T044"], "canonical_name": "positive regulation of triglyceride lipase activity", "definition": "Any process that increases the activity of triglyceride lipase. [GOC:dph]"}
{"concept_id": "C3155901", "aliases": [], "types": ["T055"], "canonical_name": "behavioral response to chemical pain", "definition": "Any process that results in a change in the behaviour of an organism as a result of a chemical pain stimulus. [GOC:dph]"}
{"concept_id": "C3155902", "aliases": [], "types": ["T055"], "canonical_name": "behavioral response to acetic acid induced pain", "definition": "Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus. [GOC:dph]"}
{"concept_id": "C3155903", "aliases": [], "types": ["T055"], "canonical_name": "behavioral response to formalin induced pain", "definition": "Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus. [GOC:dph]"}
{"concept_id": "C3155904", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of testicular blood vessel morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3155905", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of testicular vasculature morphogenesis"}
{"concept_id": "C3155906", "aliases": [], "types": ["T044"], "canonical_name": "testosterone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155907", "aliases": ["determination of cardiac left/right asymmetry"], "types": ["T040"], "canonical_name": "determination of heart left/right asymmetry", "definition": "Determination of the asymmetric location of the heart with respect to the left and right halves of the organism. [GOC:dph, GOC:mtg_heart]"}
{"concept_id": "C3155908", "aliases": ["activin receptor signalling pathway involved in heart jogging"], "types": ["T044"], "canonical_name": "activin receptor signaling pathway involved in heart jogging", "definition": "The series of molecular signals initiated by the binding of a member of the activin family to its receptor on the surface of a target cell, and contributing to the process of heart jogging. [GOC:dph, GOC:mtg_heart, GOC:signaling]"}
{"concept_id": "C3155909", "aliases": [], "types": ["T042"], "canonical_name": "mammillary axonal complex development", "definition": "The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain. [GOC:dph, GOC:yaf, PMID:10662642]"}
{"concept_id": "C3155910", "aliases": [], "types": ["T042"], "canonical_name": "mammillothalamic axonal tract development", "definition": "The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit. [GOC:dph, GOC:yaf, PMID:10662642]"}
{"concept_id": "C3155911", "aliases": [], "types": ["T042"], "canonical_name": "mammillotectal axonal tract development", "definition": "The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus. [GOC:dph, GOC:yaf, PMID:10662642]"}
{"concept_id": "C3155912", "aliases": [], "types": ["T042"], "canonical_name": "mammillotegmental axonal tract development", "definition": "The process in which the mammillotegmental tract progresses over time, from its formation to the mature structure. The mammillotegmental tract is the collection of axons that connects the ventral diencephalon to the tegmentum and pons. [GOC:dph, GOC:yaf, PMID:10662642]"}
{"concept_id": "C3155913", "aliases": [], "types": ["T042"], "canonical_name": "mammary gland lobule development", "definition": "The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155914", "aliases": [], "types": ["T042"], "canonical_name": "corpora quadrigemina development", "definition": "The progression of the corpora quadrigemina over time, from its formation to the mature structure. The corpora quadrigemina is a part of the midbrain that is made up of the superior and inferior colliculi. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155915", "aliases": [], "types": ["T042"], "canonical_name": "inferior colliculus development", "definition": "The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155916", "aliases": [], "types": ["T042"], "canonical_name": "superior colliculus development", "definition": "The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3155917", "aliases": [], "types": ["T043"], "canonical_name": "cell migration in diencephalon", "definition": "The orderly movement of a cell that will reside in the diencephalon. [GOC:dph]"}
{"concept_id": "C3155918", "aliases": [], "types": ["T043"], "canonical_name": "Malpighian tubule tip cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells. [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213]"}
{"concept_id": "C3155919", "aliases": [], "types": ["T040"], "canonical_name": "trabecula morphogenesis", "definition": "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. [GOC:dph]"}
{"concept_id": "C3155920", "aliases": [], "types": ["T042"], "canonical_name": "heart trabecula morphogenesis", "definition": "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. [GOC:dph]"}
{"concept_id": "C3155921", "aliases": [], "types": ["T043"], "canonical_name": "fibroblast proliferation involved in heart morphogenesis", "definition": "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart. [GOC:dph]"}
{"concept_id": "C3155922", "aliases": [], "types": ["T042"], "canonical_name": "closure of optic fissure", "definition": "The closure of the temporary ventral gap in the optic cup that contributes to its shaping. [GOC:dph]"}
{"concept_id": "C3155923", "aliases": [], "types": ["T042"], "canonical_name": "closure or choriod fissure"}
{"concept_id": "C3155927", "aliases": [], "types": ["T044"], "canonical_name": "lipoprotein particle receptor binding", "definition": "Binding to a lipoprotein particle receptor. [GOC:BHF, GOC:rl]"}
{"concept_id": "C3155931", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of thiamine diphosphate biosynthetic process"}
{"concept_id": "C3155932", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of thiamine biosynthetic process"}
{"concept_id": "C3155933", "aliases": [], "types": ["T045"], "canonical_name": "mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication", "definition": "A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3155934", "aliases": ["DNA-dependent transcriptional preinitiation complex assembly", "DNA-templated transcriptional preinitiation complex assembly"], "types": ["T044"], "canonical_name": "transcription preinitiation complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription. [GOC:jp, GOC:txnOH]"}
{"concept_id": "C3155937", "aliases": [], "types": ["T043"], "canonical_name": "50S ribosomal subunit assembly"}
{"concept_id": "C3155938", "aliases": [], "types": ["T043"], "canonical_name": "60S ribosomal subunit assembly"}
{"concept_id": "C3155939", "aliases": [], "types": ["T043"], "canonical_name": "30S ribosomal subunit assembly"}
{"concept_id": "C3155940", "aliases": [], "types": ["T043"], "canonical_name": "40S ribosomal subunit assembly"}
{"concept_id": "C3155941", "aliases": [], "types": ["T043"], "canonical_name": "50S ribosomal subunit export from nucleus"}
{"concept_id": "C3155942", "aliases": [], "types": ["T043"], "canonical_name": "60S ribosomal subunit export from nucleus"}
{"concept_id": "C3155943", "aliases": [], "types": ["T043"], "canonical_name": "30S ribosomal subunit export from nucleus"}
{"concept_id": "C3155944", "aliases": [], "types": ["T043"], "canonical_name": "40S ribosomal subunit export from nucleus"}
{"concept_id": "C3155945", "aliases": ["fatty-acyl-coenzyme A binding"], "types": ["T044"], "canonical_name": "fatty-acyl-CoA binding", "definition": "Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. [GOC:jl, GOC:krc, ISBN:0198506732]"}
{"concept_id": "C3155954", "aliases": [], "types": ["T044"], "canonical_name": "acid invertase activity"}
{"concept_id": "C3155955", "aliases": [], "types": ["T044"], "canonical_name": "alkaline invertase activity"}
{"concept_id": "C3155956", "aliases": [], "types": ["T044"], "canonical_name": "beta-h-fructosidase activity"}
{"concept_id": "C3155957", "aliases": [], "types": ["T044"], "canonical_name": "fructosylinvertase activity"}
{"concept_id": "C3155958", "aliases": [], "types": ["T044"], "canonical_name": "glucosucrase activity"}
{"concept_id": "C3155959", "aliases": [], "types": ["T044"], "canonical_name": "maxinvert L 1000 activity"}
{"concept_id": "C3155960", "aliases": [], "types": ["T044"], "canonical_name": "saccharase activity"}
{"concept_id": "C3155961", "aliases": [], "types": ["T044"], "canonical_name": "alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis"}
{"concept_id": "C3155962", "aliases": [], "types": ["T044"], "canonical_name": "beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis"}
{"concept_id": "C3155963", "aliases": [], "types": ["T044"], "canonical_name": "sucrase activity"}
{"concept_id": "C3155964", "aliases": [], "types": ["T044"], "canonical_name": "sucrose hydrolysis"}
{"concept_id": "C3155965", "aliases": [], "types": ["T044"], "canonical_name": "PDK activity"}
{"concept_id": "C3155967", "aliases": [], "types": ["T044"], "canonical_name": "MAP kinase 1 activity"}
{"concept_id": "C3155972", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to purine-containing compound", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. [GOC:mah]"}
{"concept_id": "C3155978", "aliases": ["mating-type pheromone secretion involved in conjugation with cellular fusion"], "types": ["T043"], "canonical_name": "mating pheromone secretion involved in positive regulation of conjugation with cellular fusion", "definition": "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that positively regulates a conjugation process that results in the union of cellular and genetic information from compatible mating types. [GOC:elh, GOC:jh, GOC:mah]"}
{"concept_id": "C3155979", "aliases": ["response to bone morphogenetic protein stimulus", "response to BMP stimulus"], "types": ["T043"], "canonical_name": "response to BMP", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C3155980", "aliases": ["cellular response to bone morphogenetic protein stimulus"], "types": ["T043"], "canonical_name": "cellular response to BMP stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. [GOC:mah, GOC:yaf]"}
{"concept_id": "C3155981", "aliases": ["response to FGF stimulus", "response to fibroblast growth factor stimulus"], "types": ["T043"], "canonical_name": "response to fibroblast growth factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. [GOC:mah]"}
{"concept_id": "C3155984", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell cycle cytokinesis"}
{"concept_id": "C3155987", "aliases": ["ER cisternal network"], "types": ["T026"], "canonical_name": "endoplasmic reticulum cisternal network", "definition": "A subcompartment of the endoplasmic reticulum consisting of flattened, disc-shaped domains known as cisternae. These are typically found close to the nucleus and are generally more prominent in secretory cells. [GOC:vw, PMID:16469703, PMID:20434336]"}
{"concept_id": "C3155988", "aliases": ["ER tubular network"], "types": ["T026"], "canonical_name": "endoplasmic reticulum tubular network", "definition": "A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. [GOC:vw, PMID:16469703, PMID:20434336]"}
{"concept_id": "C3155989", "aliases": ["endoplasmic reticulum cisternal network organisation", "ER cisternal network organisation", "ER cisternal network organization"], "types": ["T043"], "canonical_name": "endoplasmic reticulum cisternal network organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. [GOC:vw, PMID:16469703, PMID:20434336]"}
{"concept_id": "C3155990", "aliases": ["ER cisternal network assembly", "ER cisternal network formation", "endoplasmic reticulum cisternal network formation"], "types": ["T043"], "canonical_name": "endoplasmic reticulum cisternal network assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. [GOC:mah, PMID:16469703, PMID:20434336]"}
{"concept_id": "C3155991", "aliases": ["ER cisternal network maintenance"], "types": ["T043"], "canonical_name": "endoplasmic reticulum cisternal network maintenance", "definition": "The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. [GOC:mah, PMID:16469703, PMID:20434336]"}
{"concept_id": "C3155992", "aliases": ["ER tubular network organization", "endoplasmic reticulum tubular network organisation", "ER tubular network organisation"], "types": ["T043"], "canonical_name": "endoplasmic reticulum tubular network organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section. [GOC:vw, PMID:16469703, PMID:20434336]"}
{"concept_id": "C3155993", "aliases": ["ER tubular network formation", "endoplasmic reticulum tubular network assembly", "ER tubular network assembly"], "types": ["T043"], "canonical_name": "endoplasmic reticulum tubular network formation", "definition": "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section. [GOC:mah, GOC:vw, PMID:16469703, PMID:20434336]"}
{"concept_id": "C3155994", "aliases": ["ER tubular network maintenance"], "types": ["T043"], "canonical_name": "endoplasmic reticulum tubular network maintenance", "definition": "The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section. [GOC:mah, PMID:16469703, PMID:20434336]"}
{"concept_id": "C3155995", "aliases": ["spindle pole body localization in nuclear envelope", "spindle pole body localization to nuclear envelope"], "types": ["T043"], "canonical_name": "spindle pole body localisation in nuclear envelope"}
{"concept_id": "C3155997", "aliases": ["Regulated upon Activation, Normal T-cell Expressed, and Secreted binding", "RANTES binding", "CCL5 binding"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 5 binding", "definition": "Binding to chemokine (C-C motif) ligand 5. [GOC:add, GOC:amm]"}
{"concept_id": "C3155998", "aliases": ["bacillithiol metabolism"], "types": ["T044"], "canonical_name": "bacillithiol metabolic process", "definition": "The chemical reactions and pathways involving bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species. [GOC:dh, PMID:20308541]"}
{"concept_id": "C3155999", "aliases": ["bacillithiol biosynthesis", "bacillithiol synthesis", "bacillithiol anabolism", "bacillithiol formation"], "types": ["T044"], "canonical_name": "bacillithiol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species. [GOC:dh, PMID:20308541]"}
{"concept_id": "C3156000", "aliases": [], "types": ["T044"], "canonical_name": "CAP-Gly domain binding", "definition": "Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets. [GOC:mah, InterPro:IPR000938]"}
{"concept_id": "C3156001", "aliases": [], "types": ["T044"], "canonical_name": "K11-linked polyubiquitin modification-dependent protein binding", "definition": "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein. [GOC:sp, PMID:18775313]"}
{"concept_id": "C3156002", "aliases": [], "types": ["T044"], "canonical_name": "K6-linked polyubiquitin modification-dependent protein binding", "definition": "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein. [GOC:sp, PMID:17525341, PMID:20351172]"}
{"concept_id": "C3156003", "aliases": ["LUBAC complex location"], "types": ["T026"], "canonical_name": "LUBAC complex", "definition": "A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex. [GOC:sp, PMID:17006537, PMID:19136968, PMID:21455180]"}
{"concept_id": "C3156004", "aliases": ["response to prostaglandin D stimulus"], "types": ["T043"], "canonical_name": "response to prostaglandin D", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. [GOC:sl]"}
{"concept_id": "C3156005", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to prostaglandin D stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. [GOC:sl]"}
{"concept_id": "C3156006", "aliases": [], "types": ["T044"], "canonical_name": "podosome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. [GOC:mah, GOC:sl]"}
{"concept_id": "C3156007", "aliases": [], "types": ["T040"], "canonical_name": "regulation of podosome assembly", "definition": "Any process that modulates the frequency, rate or extent of podosome assembly. [GOC:mah, GOC:sl]"}
{"concept_id": "C3156008", "aliases": ["down regulation of podosome assembly", "downregulation of podosome assembly", "down-regulation of podosome assembly"], "types": ["T043"], "canonical_name": "negative regulation of podosome assembly", "definition": "Any process that stops, prevents or reduces the rate or extent of podosome assembly. [GOC:mah, GOC:sl]"}
{"concept_id": "C3156009", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of podosome assembly"}
{"concept_id": "C3156010", "aliases": ["up regulation of podosome assembly", "up-regulation of podosome assembly", "upregulation of podosome assembly"], "types": ["T043"], "canonical_name": "positive regulation of podosome assembly", "definition": "Any process that activates or increases the rate or extent of podosome assembly. [GOC:mah, GOC:sl]"}
{"concept_id": "C3156011", "aliases": ["stimulation of podosome assembly"], "types": ["T043"], "canonical_name": "activation of podosome assembly"}
{"concept_id": "C3156013", "aliases": ["potassium ion membrane transport"], "types": ["T044"], "canonical_name": "potassium ion transmembrane transport", "definition": "A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C3156014", "aliases": [], "types": ["T045"], "canonical_name": "replication fork arrest involved in DNA replication termination", "definition": "A replication fork arrest process that contributes to the termination of DNA replication. [GOC:mah, PMID:17347517, PMID:20797631]"}
{"concept_id": "C3156015", "aliases": [], "types": ["T026"], "canonical_name": "satellite fibril", "definition": "An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section). [GOC:mah, GOC:sl, PMID:20108326]"}
{"concept_id": "C3156016", "aliases": [], "types": ["T044"], "canonical_name": "regulation of fever generation by regulation of prostaglandin biosynthesis", "definition": "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. [GOC:BHF, GOC:dph, GOC:mah]"}
{"concept_id": "C3156017", "aliases": [], "types": ["T044"], "canonical_name": "regulation of fever generation by regulation of prostaglandin secretion", "definition": "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell. [GOC:BHF, GOC:dph, GOC:mah]"}
{"concept_id": "C3156018", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of fever generation by positive regulation of prostaglandin biosynthesis", "definition": "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. [GOC:BHF, GOC:dph, GOC:mah]"}
{"concept_id": "C3156019", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of fever generation by positive regulation of prostaglandin secretion", "definition": "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell. [GOC:BHF, GOC:dph, GOC:mah]"}
{"concept_id": "C3156020", "aliases": ["plasma lipoprotein particle binding"], "types": ["T044"], "canonical_name": "lipoprotein particle binding", "definition": "Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156021", "aliases": [], "types": ["T044"], "canonical_name": "plasma lipoprotein binding"}
{"concept_id": "C3156022", "aliases": [], "types": ["T044"], "canonical_name": "protein-lipid complex binding", "definition": "Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156023", "aliases": ["IDL binding", "intermediate-density lipoprotein binding"], "types": ["T044"], "canonical_name": "intermediate-density lipoprotein particle binding", "definition": "Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156024", "aliases": ["type II transmembrane protein insertion into ER membrane", "protein insertion of tail-anchored membrane proteins into ER membrane", "tail-anchored membrane protein insertion into endoplasmic reticulum membrane"], "types": ["T043"], "canonical_name": "tail-anchored membrane protein insertion into ER membrane", "definition": "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region. [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]"}
{"concept_id": "C3156025", "aliases": ["MMXD complex location", "MMS19-MIP18-XPD complex location", "MMS19-MIP18-XPD complex"], "types": ["T026"], "canonical_name": "MMXD complex", "definition": "A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation. [GOC:sp, PMID:20797633]"}
{"concept_id": "C3156026", "aliases": ["Bag6 complex location", "Bag6 complex", "BAT3 complex location", "BAG6-UBL4A-TRC35 complex location", "BAG6-UBL4A-TRC35 complex"], "types": ["T026"], "canonical_name": "BAT3 complex", "definition": "A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A. [GOC:bm, PMID:20676083, PMID:21636303]"}
{"concept_id": "C3156027", "aliases": ["deubiquitinating module", "deubiquitination module", "DUBm complex location"], "types": ["T026"], "canonical_name": "DUBm complex", "definition": "A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p. [PMID:19226466, PMID:20395473]"}
{"concept_id": "C3156028", "aliases": ["SAGA DUBm complex location"], "types": ["T026"], "canonical_name": "SAGA DUBm complex"}
{"concept_id": "C3156029", "aliases": ["N box binding", "N-box promoter binding"], "types": ["T045"], "canonical_name": "N-box binding", "definition": "Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses. [GOC:yaf, PMID:11498047]"}
{"concept_id": "C3156030", "aliases": ["FANCM-MHF complex location"], "types": ["T026"], "canonical_name": "FANCM-MHF complex", "definition": "A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes. [GOC:mah, GOC:vw, PMID:20347428]"}
{"concept_id": "C3156031", "aliases": ["protein-containing complex subunit organization", "protein complex subunit organization", "protein complex subunit organisation"], "types": ["T043"], "canonical_name": "protein-containing complex organization", "definition": "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. [GOC:mah]"}
{"concept_id": "C3156032", "aliases": ["protein-carbohydrate complex subunit organisation"], "types": ["T043"], "canonical_name": "protein-carbohydrate complex subunit organization", "definition": "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex. [GOC:mah]"}
{"concept_id": "C3156033", "aliases": ["DNA-protein complex subunit organization", "protein-DNA complex subunit organisation"], "types": ["T043"], "canonical_name": "protein-DNA complex subunit organization", "definition": "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. [GOC:mah]"}
{"concept_id": "C3156034", "aliases": ["protein-lipid complex subunit organisation"], "types": ["T043"], "canonical_name": "protein-lipid complex subunit organization", "definition": "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. [GOC:mah]"}
{"concept_id": "C3156035", "aliases": ["RNA-protein complex subunit organization", "ribonucleoprotein complex subunit organisation", "protein-RNA complex subunit organization"], "types": ["T043"], "canonical_name": "ribonucleoprotein complex subunit organization", "definition": "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. [GOC:mah]"}
{"concept_id": "C3156036", "aliases": ["plasma lipoprotein particle organisation"], "types": ["T044"], "canonical_name": "plasma lipoprotein particle organization", "definition": "A protein-lipid complex subunit organization process that results in the formation, disassembly, or alteration of a plasma lipoprotein particle. A plasma lipoprotein particle is a spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156037", "aliases": ["APOE recycling"], "types": ["T043"], "canonical_name": "apolipoprotein E recycling", "definition": "The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle. [GOC:BHF, PMID:16373604]"}
{"concept_id": "C3156038", "aliases": [], "types": ["T043"], "canonical_name": "plasma lipoprotein particle disassembly", "definition": "The disaggregation of a plasma lipoprotein particle into its constituent components. [GOC:mah]"}
{"concept_id": "C3156039", "aliases": [], "types": ["T038"], "canonical_name": "triglyceride-rich lipoprotein particle clearance", "definition": "The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF]"}
{"concept_id": "C3156040", "aliases": ["IDL clearance"], "types": ["T038"], "canonical_name": "intermediate-density lipoprotein particle clearance", "definition": "The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF]"}
{"concept_id": "C3156043", "aliases": ["mating-type pheromone secretion involved in conjugation", "mating pheromone secretion involved in regulation of conjugation"], "types": ["T043"], "canonical_name": "mating pheromone secretion involved in regulation of conjugation with cellular fusion", "definition": "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that regulates the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms. [GOC:elh, GOC:jh, GOC:mah]"}
{"concept_id": "C3156044", "aliases": [], "types": ["T043"], "canonical_name": "nectar secretion", "definition": "The controlled release of a nectar by a cell or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins. [GOC:kad, PMID:19861655]"}
{"concept_id": "C3156045", "aliases": [], "types": ["T043"], "canonical_name": "nectar production"}
{"concept_id": "C3156046", "aliases": [], "types": ["T044"], "canonical_name": "HMG box domain binding", "definition": "Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. [GOC:yaf, InterPro:IPR009071, PMID:18445004]"}
{"concept_id": "C3156047", "aliases": ["bone marrow cell proliferation"], "types": ["T043"], "canonical_name": "cell proliferation in bone marrow", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow. [GOC:mah, GOC:yaf, PMID:17063141]"}
{"concept_id": "C3156048", "aliases": ["programmed cell death, bone marrow cells", "killing of bone marrow cells", "apoptosis in bone marrow", "bone marrow cell programmed cell death by apoptosis", "bone marrow cell apoptosis", "programmed cell death of bone marrow cells by apoptosis"], "types": ["T043"], "canonical_name": "apoptotic process in bone marrow cell", "definition": "The apoptotic process in cells in the bone marrow. [GOC:mah, GOC:mtg_apoptosis, PMID:17063141]"}
{"concept_id": "C3156049", "aliases": ["cellular component organization or biogenesis at cellular level", "cellular component organisation or biogenesis at cellular level", "cellular component organisation or biogenesis"], "types": ["T043"], "canonical_name": "cellular component organization or biogenesis", "definition": "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:mah]"}
{"concept_id": "C3156055", "aliases": [], "types": ["T043"], "canonical_name": "actin filament debranching", "definition": "An actin filament severing process that results in the removal of actin filament branches specifically at the branch points. [GOC:jh, GOC:mah, PMID:20362448]"}
{"concept_id": "C3156056", "aliases": ["tumor necrosis factor superfamily member 11-mediated signaling pathway", "RANKL-mediated signaling pathway", "receptor activator of nuclear factor kappa-B ligand signaling pathway", "TNF-related activation-induced cytokine-mediated signaling pathway", "TNFSF11-mediated signalling pathway"], "types": ["T043"], "canonical_name": "TNFSF11-mediated signaling pathway", "definition": "The series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling, PMID:18606301]"}
{"concept_id": "C3156057", "aliases": ["positive regulation of ERK1 and ERK2 cascade via RANKL-mediated signaling", "positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalling"], "types": ["T044"], "canonical_name": "positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling", "definition": "Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade. [GOC:BHF, PMID:18606301]"}
{"concept_id": "C3156061", "aliases": ["fungal-type cell wall organisation or biogenesis"], "types": ["T043"], "canonical_name": "fungal-type cell wall organization or biogenesis", "definition": "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall. [GOC:mah]"}
{"concept_id": "C3156062", "aliases": [], "types": ["T043"], "canonical_name": "fungal-type cell wall disassembly", "definition": "A cellular process that results in the breakdown of a fungal-type cell wall. [GOC:mah]"}
{"concept_id": "C3156063", "aliases": [], "types": ["T040"], "canonical_name": "cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly", "definition": "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the fungal-type cell wall. [GOC:mah]"}
{"concept_id": "C3156064", "aliases": [], "types": ["T044"], "canonical_name": "neuropeptide receptor binding", "definition": "Binding to a neuropeptide receptor. [GOC:kmv, GOC:mah]"}
{"concept_id": "C3156065", "aliases": [], "types": ["T044"], "canonical_name": "beta-endorphin receptor binding", "definition": "Binding to a beta-endorphin receptor. [GOC:kmv, GOC:mah]"}
{"concept_id": "C3156066", "aliases": [], "types": ["T044"], "canonical_name": "corazonin receptor binding", "definition": "Binding to a corazonin receptor. [GOC:kmv, GOC:mah]"}
{"concept_id": "C3156067", "aliases": [], "types": ["T044"], "canonical_name": "neuropeptide F receptor binding", "definition": "Binding to a neuropeptide F receptor. [GOC:kmv, GOC:mah]"}
{"concept_id": "C3156068", "aliases": [], "types": ["T044"], "canonical_name": "proctolin receptor binding", "definition": "Binding to a proctolin receptor. [GOC:kmv, GOC:mah]"}
{"concept_id": "C3156069", "aliases": [], "types": ["T044"], "canonical_name": "tachykinin receptor binding", "definition": "Binding to a tachykinin receptor. [GOC:kmv, GOC:mah]"}
{"concept_id": "C3156070", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 1 activator activity"}
{"concept_id": "C3156071", "aliases": ["regulation of bone marrow cell proliferation"], "types": ["T043"], "canonical_name": "regulation of cell proliferation in bone marrow", "definition": "A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow. [GOC:mah, GOC:yaf, PMID:17063141]"}
{"concept_id": "C3156072", "aliases": ["up-regulation of cell proliferation in bone marrow", "upregulation of cell proliferation in bone marrow", "up regulation of cell proliferation in bone marrow", "positive regulation of bone marrow cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of cell proliferation in bone marrow", "definition": "A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow. [GOC:mah, GOC:yaf, PMID:17063141]"}
{"concept_id": "C3156073", "aliases": ["stimulation of cell proliferation in bone marrow"], "types": ["T043"], "canonical_name": "activation of cell proliferation in bone marrow"}
{"concept_id": "C3156074", "aliases": ["regulation of apoptotic process in bone marrow", "regulation of apoptosis in bone marrow"], "types": ["T043"], "canonical_name": "regulation of apoptotic process in bone marrow cell", "definition": "Any process that modulates the occurrence or rate of cell death by apoptotic process in the bone marrow. [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141]"}
{"concept_id": "C3156076", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis in bone marrow"}
{"concept_id": "C3156077", "aliases": ["response to monoamine stimulus"], "types": ["T043"], "canonical_name": "response to monoamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. [GOC:mah]"}
{"concept_id": "C3156078", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to monoamine stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. [GOC:mah]"}
{"concept_id": "C3156079", "aliases": ["response to catecholamine stimulus"], "types": ["T043"], "canonical_name": "response to catecholamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156080", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to catecholamine stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156081", "aliases": ["response to epinephrine stimulus", "response to adrenaline stimulus"], "types": ["T043"], "canonical_name": "response to epinephrine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156082", "aliases": ["cellular response to adrenaline stimulus"], "types": ["T043"], "canonical_name": "cellular response to epinephrine stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156083", "aliases": ["response to noradrenaline stimulus", "response to norepinephrine stimulus"], "types": ["T043"], "canonical_name": "response to norepinephrine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156084", "aliases": ["cellular response to noradrenaline stimulus"], "types": ["T043"], "canonical_name": "cellular response to norepinephrine stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156085", "aliases": ["adrenergic receptor signalling pathway", "adrenoceptor signaling pathway"], "types": ["T044"], "canonical_name": "adrenergic receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:BHF]"}
{"concept_id": "C3156087", "aliases": ["regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "regulation of adrenergic receptor signalling pathway"], "types": ["T043"], "definition": "Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. [GOC:BHF, GOC:mah]", "canonical_name": "regulation of adrenergic receptor signaling pathway"}
{"concept_id": "C3156088", "aliases": ["negative regulation of adrenergic receptor signalling pathway", "negative regulation of adrenergic receptor signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156089", "aliases": ["positive regulation of adrenergic receptor signalling pathway", "positive regulation of adrenergic receptor signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the adenylate cyclase-activating adrenergic receptor protein signaling pathway. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156090", "aliases": ["adrenergic receptor, adenylyl cyclase activating pathway", "activation of adenylate cyclase activity by adrenergic receptor signaling pathway", "activation of adenylate cyclase activity by adrenergic receptor signalling pathway", "adrenergic receptor, adenylate cyclase activating pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-activating adrenergic receptor signaling pathway", "definition": "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. [GOC:BHF, GOC:mah, GOC:signaling]"}
{"concept_id": "C3156091", "aliases": ["adrenergic receptor, adenylate cyclase inhibiting pathway", "adrenergic receptor, adenylyl cyclase inhibiting pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "definition": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor, and ending with the regulation of a downstream cellular process. [GOC:BHF, GOC:mah, GOC:signaling]"}
{"concept_id": "C3156092", "aliases": ["adrenergic receptor, phospholipase C activating pathway", "activation of phospholipase C activity by adrenergic receptor signalling pathway", "activation of phospholipase C activity by adrenergic receptor signaling pathway"], "types": ["T044"], "canonical_name": "phospholipase C-activating adrenergic receptor signaling pathway", "definition": "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah, GOC:signaling]"}
{"concept_id": "C3156093", "aliases": ["activation of MAPK activity by adrenergic receptor signaling pathway", "activation of MAP kinase activity by adrenergic receptor signaling pathway", "activation of MAPK activity by adrenergic receptor signalling pathway", "activation of MAP kinase activity by adrenergic receptor signalling pathway"], "types": ["T044"], "canonical_name": "MAPK-activating adrenergic receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand and leading to the activation of a MAP kinase cascade. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156095", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein N-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. [PMID:20481588]"}
{"concept_id": "C3156096", "aliases": [], "types": ["T044"], "canonical_name": "X-Pro-Lys N-terminal methyltransferase"}
{"concept_id": "C3156097", "aliases": ["4-iodo-2,5-dimethoxyphenylisopropylamine binding", "(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding", "1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding"], "types": ["T044"], "canonical_name": "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding", "definition": "Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug. [GOC:yaf, PMID:19057895]"}
{"concept_id": "C3156099", "aliases": ["macrophage apoptotic process"], "types": ["T043"], "definition": "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues. [CL:0000235, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]", "canonical_name": "macrophage apoptosis"}
{"concept_id": "C3156100", "aliases": [], "types": ["T044"], "canonical_name": "14-3-3 protein binding", "definition": "Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580]"}
{"concept_id": "C3156101", "aliases": ["CHO3- ion binding binding", "hydrogencarbonate binding"], "types": ["T044"], "canonical_name": "bicarbonate binding", "definition": "Binding to bicarbonate ions (CHO3-). [GOC:curators]"}
{"concept_id": "C3156102", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-proline dimethylation involved in translation", "definition": "An N-terminal peptidyl-proline dimethylation process that contributes to translation. [GOC:mah]"}
{"concept_id": "C3156103", "aliases": ["blood coagulation, thrombocyte activation"], "types": ["T043"], "canonical_name": "thrombocyte activation", "definition": "A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals. [GOC:lb, GOC:mah, PMID:10606877, PMID:15634265, PMID:20180901]"}
{"concept_id": "C3156104", "aliases": ["BMP signalling pathway involved in nephric duct formation"], "types": ["T044"], "canonical_name": "BMP signaling pathway involved in nephric duct formation", "definition": "The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to nephric duct formation. [GOC:mah, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156105", "aliases": [], "types": ["T044"], "canonical_name": "histone H2B conserved C-terminal lysine ubiquitination", "definition": "A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals. [GOC:mah, GOC:vw]"}
{"concept_id": "C3156106", "aliases": [], "types": ["T044"], "canonical_name": "budding yeast H2B K123 ubiquitination"}
{"concept_id": "C3156107", "aliases": [], "types": ["T044"], "canonical_name": "fission yeast H2B K119 ubiquitination"}
{"concept_id": "C3156108", "aliases": [], "types": ["T044"], "canonical_name": "mammalian H2B K120 ubiquitination"}
{"concept_id": "C3156109", "aliases": [], "types": ["T043"], "canonical_name": "odontoblast differentiation", "definition": "The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin. [GOC:sl, PMID:20425127]"}
{"concept_id": "C3156110", "aliases": ["protein localisation in cell-cell adherens junction", "protein localisation to adherens junction", "protein localization to cell-cell adherens junction", "protein localisation to cell-cell adherens junction", "protein localization in adherens junction", "protein localisation in adherens junction", "protein localization in cell-cell adherens junction"], "types": ["T043"], "canonical_name": "protein localization to adherens junction", "definition": "Any process in which a protein is transported to, and/or maintained at the adherens junction. [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237]"}
{"concept_id": "C3156113", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein serine/threonine kinase activity", "definition": "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity. [GOC:mah]"}
{"concept_id": "C3156114", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of protein serine/threonine kinase activity", "definition": "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156115", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein serine/threonine kinase activity", "definition": "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. [GOC:mah]"}
{"concept_id": "C3156116", "aliases": ["protein amino acid N-linked N-acetylglucosaminylation via asparagine"], "types": ["T044"], "canonical_name": "protein N-linked N-acetylglucosaminylation via asparagine", "definition": "A process of protein N-linked glycosylation via asparagine in which N-acetylglucosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)amino-4-oxobutanoic acid residue. [GOC:pr, RESID:AA0151]"}
{"concept_id": "C3156117", "aliases": ["protein amino acid N-linked N-acetylgalactosaminylation via asparagine"], "types": ["T044"], "canonical_name": "protein N-linked N-acetylgalactosaminylation via asparagine", "definition": "A process of protein N-linked glycosylation via asparagine in which N-acetylgalactosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid residue. [GOC:pr, RESID:AA0420]"}
{"concept_id": "C3156118", "aliases": ["protein amino acid N-linked glucosylation via asparagine"], "types": ["T044"], "canonical_name": "protein N-linked glucosylation via asparagine", "definition": "A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue. [GOC:pr, RESID:AA0421]"}
{"concept_id": "C3156119", "aliases": ["context dependent regulatory domain binding"], "types": ["T044"], "canonical_name": "CRD domain binding", "definition": "Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins. [GOC:yaf, PMID:19460168]"}
{"concept_id": "C3156120", "aliases": ["determination of gut left/right asymmetry", "determination of left/right asymmetry of the digestive tract"], "types": ["T040"], "canonical_name": "determination of digestive tract left/right asymmetry", "definition": "Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:cvs]"}
{"concept_id": "C3156121", "aliases": [], "types": ["T040"], "canonical_name": "determination of intestine left/right asymmetry", "definition": "Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism. [GOC:cvs]"}
{"concept_id": "C3156122", "aliases": [], "types": ["T040"], "canonical_name": "determination of stomach left/right asymmetry", "definition": "Determination of the asymmetric location of the stomach with respect to the left and right halves of the organism. [GOC:cvs]"}
{"concept_id": "C3156123", "aliases": [], "types": ["T040"], "canonical_name": "determination of liver left/right asymmetry", "definition": "Determination of the asymmetric location of the liver with respect to the left and right halves of the organism. [GOC:cvs]"}
{"concept_id": "C3156124", "aliases": [], "types": ["T043"], "canonical_name": "synchronous neurotransmitter secretion", "definition": "Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion. [GOC:dsf, PMID:19477156, PMID:20643933]"}
{"concept_id": "C3156125", "aliases": [], "types": ["T043"], "canonical_name": "asynchronous neurotransmitter secretion", "definition": "Release of neurotransmitter at the synapse that persists for tens to hundreds of milliseconds after action potential invasion. [GOC:dsf, PMID:19477156, PMID:20643933]"}
{"concept_id": "C3156126", "aliases": ["citrate carrier activity"], "types": ["T044"], "canonical_name": "citrate secondary active transmembrane transporter activity", "definition": "Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mah, GOC:mtg_transport, GOC:vw]"}
{"concept_id": "C3156127", "aliases": ["prominin-containing extracellular membrane vesicle"], "types": ["T026"], "canonical_name": "prominosome", "definition": "An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known. [GOC:vesicles, PMID:15976444, PMID:17109118, PMID:17283184]"}
{"concept_id": "C3156128", "aliases": ["protein amino acid lysylation"], "types": ["T044"], "canonical_name": "protein-lysine lysylation", "definition": "The addition of lysine group to a lysine residue in a protein, producing N6-(lysyl)-L-lysine. This modification is observed in, and is probably unique to, translation elongation factor P (EF-P). [GOC:imk, GOC:jsg, PMID:20729861]"}
{"concept_id": "C3156129", "aliases": [], "types": ["T044"], "canonical_name": "dipeptide transmembrane transporter activity", "definition": "Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. [GOC:mah]"}
{"concept_id": "C3156130", "aliases": ["urea membrane transport"], "types": ["T043"], "canonical_name": "urea transmembrane transport", "definition": "The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C3156131", "aliases": ["G quartet DNA formation", "G-quartet DNA formation", "G quadruplex DNA formation"], "types": ["T045"], "canonical_name": "G-quadruplex DNA formation", "definition": "A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature. [GOC:sre, PMID:20098422]"}
{"concept_id": "C3156132", "aliases": [], "types": ["T026"], "definition": "A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing. [PMID:10564273, PMID:11598190, PMID:8654386]", "canonical_name": "cleavage body"}
{"concept_id": "C3156133", "aliases": ["cohesin localisation to chromatin", "cohesin localization to chromatin", "cohesin association with chromatin"], "types": ["T043"], "canonical_name": "cohesin loading", "definition": "The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA. [GOC:dph, GOC:mah, GOC:vw, PMID:10882066, PMID:17113138, PMID:26687354]"}
{"concept_id": "C3156134", "aliases": ["regulation of cohesin association with chromatin", "regulation of cohesin localisation to chromatin", "regulation of cohesin localization to chromatin"], "types": ["T043"], "canonical_name": "regulation of cohesin loading", "definition": "Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin. [GOC:lb, GOC:mah, PMID:17113138]"}
{"concept_id": "C3156135", "aliases": ["negative regulation of cohesin association with chromatin", "negative regulation of cohesin localization to chromatin", "negative regulation of cohesin localisation to chromatin"], "types": ["T043"], "canonical_name": "negative regulation of cohesin loading", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin. [GOC:lb, GOC:mah, PMID:17113138]"}
{"concept_id": "C3156136", "aliases": ["CCL-22 production", "CCL22 production", "C-C motif chemokine 22 production"], "types": ["T040"], "canonical_name": "chemokine (C-C motif) ligand 22 production", "definition": "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:18832724]"}
{"concept_id": "C3156137", "aliases": ["TSLP production"], "types": ["T040"], "canonical_name": "thymic stromal lymphopoietin production", "definition": "The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:17129180]"}
{"concept_id": "C3156138", "aliases": ["endocannabinoid signalling pathway"], "types": ["T044"], "canonical_name": "endocannabinoid signaling pathway", "definition": "The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol. [GOC:bf, GOC:mah, PMID:15550444]"}
{"concept_id": "C3156139", "aliases": ["octopamine signalling pathway"], "types": ["T044"], "canonical_name": "octopamine signaling pathway", "definition": "The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor. [GOC:mah, PMID:15355245]"}
{"concept_id": "C3156140", "aliases": ["tyramine signalling pathway"], "types": ["T044"], "canonical_name": "tyramine signaling pathway", "definition": "The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor. [GOC:mah, PMID:15355245]"}
{"concept_id": "C3156141", "aliases": [], "types": ["T044"], "canonical_name": "alpha-tubulin acetylation", "definition": "The addition of an acetyl group to the lysine 40 residue of alpha-tubulin. [GOC:kmv, PMID:17786050]"}
{"concept_id": "C3156142", "aliases": ["negative regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle"], "types": ["T045"], "canonical_name": "negative regulation of transcription involved in G1/S transition of mitotic cell cycle", "definition": "Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle. [GOC:mah, GOC:vw]"}
{"concept_id": "C3156143", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle"}
{"concept_id": "C3156144", "aliases": ["positive regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle"], "types": ["T045"], "canonical_name": "positive regulation of transcription involved in G1/S transition of mitotic cell cycle", "definition": "Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle. [GOC:mah, GOC:vw]"}
{"concept_id": "C3156145", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle"}
{"concept_id": "C3156146", "aliases": [], "types": ["T045"], "canonical_name": "replication fork reversal", "definition": "Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved. [PMID:19406929]"}
{"concept_id": "C3156147", "aliases": [], "types": ["T044"], "canonical_name": "Arp2/3 complex binding", "definition": "Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). [GOC:mah]"}
{"concept_id": "C3156148", "aliases": ["vitamin B1 transmembrane transport", "thiamine membrane transport", "thiamin transmembrane transport"], "types": ["T043"], "canonical_name": "thiamine transmembrane transport", "definition": "The process in which thiamine is transported across a membrane. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:mah]"}
{"concept_id": "C3156149", "aliases": ["octopamine signalling pathway involved in response to food"], "types": ["T044"], "canonical_name": "octopamine signaling pathway involved in response to food", "definition": "The series of molecular signals initiated by binding of octopamine to a receptor on the surface of the target cell that contributes to a response to a food stimulus. [GOC:mah, PMID:19609300]"}
{"concept_id": "C3156150", "aliases": ["coreceptor activity involved in Wnt-activated signaling pathway", "coreceptor activity involved in Wnt receptor signalling pathway", "Wnt co-receptor activity", "coreceptor activity involved in Wnt receptor signaling pathway"], "types": ["T044"], "canonical_name": "coreceptor activity involved in Wnt signaling pathway", "definition": "In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156152", "aliases": [], "types": ["T043"], "canonical_name": "vitamin A transport", "definition": "The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid. [GOC:mah, PMID:16011460, PMID:1924551]"}
{"concept_id": "C3156153", "aliases": [], "types": ["T043"], "canonical_name": "vitamin A uptake and transport"}
{"concept_id": "C3156154", "aliases": ["vitamin A import", "vitamin A uptake"], "types": ["T043"], "canonical_name": "vitamin A import into cell", "definition": "The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid. [GOC:mah, PMID:16011460, PMID:1924551]"}
{"concept_id": "C3156155", "aliases": [], "types": ["T040"], "canonical_name": "nitrogen cycle metabolic process", "definition": "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle]"}
{"concept_id": "C3156156", "aliases": ["XPC complex location"], "types": ["T026"], "canonical_name": "XPC complex", "definition": "A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2. [PMID:11279143, PMID:15964821, PMID:19941824]"}
{"concept_id": "C3156157", "aliases": ["Myc-Max complex location"], "types": ["T026"], "canonical_name": "Myc-Max complex", "definition": "A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max. [GOC:cna, PMID:16620027, PMID:16620031, PMID:20170194]"}
{"concept_id": "C3156158", "aliases": [], "types": ["T040"], "canonical_name": "regulation of flagellar cell motility by regulation of motor speed"}
{"concept_id": "C3156159", "aliases": ["cis acting DNA replication termination"], "types": ["T045"], "canonical_name": "cis-acting DNA replication termination", "definition": "A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing. [GOC:vw, PMID:20850009]"}
{"concept_id": "C3156160", "aliases": [], "types": ["T044"], "canonical_name": "protein deubiquitination involved in ubiquitin-dependent protein catabolic process", "definition": "The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism. [GOC:mah]"}
{"concept_id": "C3156161", "aliases": [], "types": ["T043"], "canonical_name": "activated B cell apoptosis"}
{"concept_id": "C3156162", "aliases": ["oxidized flavin adenine dinucleotide binding", "oxidized flavine-adenine dinucleotide binding"], "types": ["T044"], "canonical_name": "FAD binding", "definition": "Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]"}
{"concept_id": "C3156163", "aliases": ["reduced flavine-adenine dinucleotide binding", "reduced flavin adenine dinucleotide binding"], "types": ["T044"], "canonical_name": "FADH2 binding", "definition": "Binding to the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]"}
{"concept_id": "C3156164", "aliases": [], "types": ["T045"], "canonical_name": "conversion of methionyl-tRNA to N-formyl-methionyl-tRNA", "definition": "The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet). [GOC:jsg, PMID:5337045]"}
{"concept_id": "C3156165", "aliases": [], "types": ["T045"], "canonical_name": "conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA", "definition": "The modification process that results in the conversion of O-phosphoserine charged on a tRNA(Cys) to cysteinyl-tRNA. [GOC:jsg, PMID:17351629, PMID:18559341]"}
{"concept_id": "C3156166", "aliases": ["C-C motif chemokine 11 production", "CCL-11 production", "CCL11 production", "eotaxin-1 production"], "types": ["T040"], "canonical_name": "chemokine (C-C motif) ligand 11 production", "definition": "The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:9600955]"}
{"concept_id": "C3156167", "aliases": [], "types": ["T040"], "canonical_name": "eotaxin production"}
{"concept_id": "C3156168", "aliases": [], "types": ["T043"], "canonical_name": "recycling endosome to Golgi transport", "definition": "The directed movement of substances from recycling endosomes to the Golgi. [GOC:lb]"}
{"concept_id": "C3156170", "aliases": ["old SPB"], "types": ["T026"], "canonical_name": "old mitotic spindle pole body", "definition": "The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis. [GOC:mah, GOC:vw, PMID:15132994]"}
{"concept_id": "C3156171", "aliases": ["new SPB"], "types": ["T026"], "canonical_name": "new mitotic spindle pole body", "definition": "The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize. [GOC:mah, GOC:vw, PMID:15132994]"}
{"concept_id": "C3156172", "aliases": ["maintenance of mitotic sister chromatin cohesion along arms", "maintenance of sister chromatin cohesion along arms at mitosis"], "types": ["T043"], "canonical_name": "maintenance of mitotic sister chromatid cohesion, arms", "definition": "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. [GOC:mah, PMID:1708436]"}
{"concept_id": "C3156173", "aliases": ["maintenance of sister chromatin cohesion at centromere at mitosis", "maintenance of mitotic sister chromatin cohesion at centromere", "maintenance of centromeric mitotic sister chromatin cohesion"], "types": ["T043"], "canonical_name": "maintenance of mitotic sister chromatid cohesion, centromeric", "definition": "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. [GOC:mah, PMID:1708436]"}
{"concept_id": "C3156174", "aliases": ["mitotic sister chromatid cohesion along arms", "sister chromatid cohesion along arms at mitosis"], "types": ["T043"], "canonical_name": "mitotic sister chromatid cohesion, arms", "definition": "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during mitosis. [GOC:mah]"}
{"concept_id": "C3156175", "aliases": ["centromeric mitotic sister chromatin cohesion", "mitotic sister chromatid cohesion at centromere", "sister chromatid cohesion at centromere at mitosis"], "types": ["T043"], "canonical_name": "mitotic sister chromatid cohesion, centromeric", "definition": "The cell cycle process in which centromeres of sister chromatids are joined during mitosis. [GOC:mah]"}
{"concept_id": "C3156176", "aliases": [], "types": ["T043"], "canonical_name": "fungal-type cell wall polysaccharide metabolic process", "definition": "The chemical reactions and pathways involving the polysaccharides which make up the fungal-type cell wall. [GOC:mah]"}
{"concept_id": "C3156177", "aliases": ["LPS core heptosyltransferase activity"], "types": ["T044"], "canonical_name": "lipopolysaccharide core heptosyltransferase activity", "definition": "Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+. [MetaCyc:RXN0-5122]"}
{"concept_id": "C3156178", "aliases": [], "types": ["T044"], "canonical_name": "lipid A-core heptosyltransferase activity", "definition": "Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+. [MetaCyc:RXN0-5127]"}
{"concept_id": "C3156179", "aliases": ["fungal-type cell wall 1,3-beta-glucan metabolism", "fungal-type cell wall 1,3-beta-D-glucan metabolic process", "fungal-type cell wall beta-1,3 glucan metabolism", "fungal-type cell wall beta-1,3 glucan metabolic process"], "types": ["T044"], "canonical_name": "fungal-type cell wall (1->3)-beta-D-glucan metabolic process", "definition": "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of fungi. [GOC:mah]"}
{"concept_id": "C3156181", "aliases": ["fungal-type cell wall 1,3-beta-glucan formation", "fungal-type cell wall beta-1,3-glucan biosynthesis", "fungal-type cell wall beta-1,3-glucan biosynthetic process", "fungal-type cell wall beta-1,3-glucan anabolism", "fungal-type cell wall 1,3-beta-glucan biosynthesis", "fungal-type cell wall beta-1,3-glucan formation", "fungal-type cell wall beta-1,3-glucan synthesis", "fungal-type cell wall 1,3-beta-glucan synthesis", "fungal-type cell wall 1,3-beta-glucan anabolism", "fungal-type cell wall 1,3-beta-D-glucan biosynthetic process"], "types": ["T044"], "canonical_name": "fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in fungal cell walls. [GOC:mah]"}
{"concept_id": "C3156183", "aliases": ["extracellular vesicular exosome assembly"], "types": ["T043"], "canonical_name": "extracellular exosome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458]"}
{"concept_id": "C3156184", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan L,D-transpeptidase activity", "definition": "Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine. [MetaCyc:RXN-11349]"}
{"concept_id": "C3156185", "aliases": ["bacterial-type flagellar cell motility", "flagellin-based flagellar cell motility"], "types": ["T043"], "canonical_name": "bacterial-type flagellum-dependent cell motility", "definition": "Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. [GOC:cilia, GOC:krc, GOC:mah]"}
{"concept_id": "C3156187", "aliases": ["cell swimming motility"], "types": ["T043"], "canonical_name": "cell swimming", "definition": "Cell motility that results in the smooth movement of a cell through a liquid medium. [PMID:18461074]"}
{"concept_id": "C3156188", "aliases": ["cell gliding motility"], "types": ["T043"], "canonical_name": "cell gliding", "definition": "Cell motility that results in the smooth movement of a cell along a solid surface. [PMID:18461074]"}
{"concept_id": "C3156189", "aliases": ["bacterial-type flagellar swimming motility", "bacterial-type flagellum-mediated cell swimming"], "types": ["T043"], "canonical_name": "bacterial-type flagellum-dependent swimming motility", "definition": "Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium. [GOC:cilia, PMID:18461074]"}
{"concept_id": "C3156190", "aliases": ["bacterial-type flagellum-mediated cell swarming", "bacterial-type flagellar swarming motility"], "types": ["T043"], "canonical_name": "bacterial-type flagellum-dependent swarming motility", "definition": "Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. [GOC:cilia, PMID:14527279, PMID:18461074]"}
{"concept_id": "C3156191", "aliases": ["cytoskeleton-mediated swimming motility"], "types": ["T043"], "canonical_name": "cytoskeleton-mediated cell swimming", "definition": "Cell motility in which contractile cytoskeletal elements alter cell shape, resulting in the smooth movement of a cell through a liquid medium. [PMID:18461074]"}
{"concept_id": "C3156192", "aliases": [], "types": ["T043"], "canonical_name": "cell surface adhesin-mediated gliding motility", "definition": "Cell gliding that results from the actions of cell surface adhesin proteins that are propelled by membrane motor proteins. [PMID:18461074]"}
{"concept_id": "C3156193", "aliases": [], "types": ["T042"], "canonical_name": "exit from diapause", "definition": "The dormancy process that results in exit from diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. [GOC:mah]"}
{"concept_id": "C3156194", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of diapause", "definition": "The dormancy process that results an organism remaining in diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. [GOC:mah]"}
{"concept_id": "C3156195", "aliases": [], "types": ["T042"], "canonical_name": "exit from reproductive diapause", "definition": "The dormancy process that results in exit from reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. [GOC:mah]"}
{"concept_id": "C3156196", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of reproductive diapause", "definition": "The dormancy process that results an organism remaining in reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. [GOC:mah]"}
{"concept_id": "C3156197", "aliases": [], "types": ["T043"], "canonical_name": "multivesicular body sorting pathway", "definition": "A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. [GOC:mah, PMID:17603537]"}
{"concept_id": "C3156198", "aliases": ["Rag GEF", "MAPKSP1/ROBLD3/C11orf59 complex", "Ragulator complex location", "MAPKSP1/ROBLD3/C11orf59 complex location"], "types": ["T026"], "canonical_name": "Ragulator complex", "definition": "A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signalling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]"}
{"concept_id": "C3156199", "aliases": ["beta-transducin repeat domain binding", "WD domain binding"], "types": ["T044"], "canonical_name": "WD40-repeat domain binding", "definition": "Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain. [GOC:yaf, InterPro:IPR017986]"}
{"concept_id": "C3156200", "aliases": ["protein localisation to spindle pole body"], "types": ["T043"], "canonical_name": "protein localization to spindle pole body", "definition": "A process in which a protein is transported to, or maintained at, the spindle pole body. [GOC:mah]"}
{"concept_id": "C3156201", "aliases": ["establishment of protein localisation to spindle pole body"], "types": ["T043"], "canonical_name": "establishment of protein localization to spindle pole body", "definition": "The directed movement of a protein to a specific location at the spindle pole body. [GOC:mah]"}
{"concept_id": "C3156202", "aliases": ["maintenance of protein location in spindle pole body", "maintenance of protein location at spindle pole body"], "types": ["T038"], "canonical_name": "maintenance of protein location to spindle pole body", "definition": "Any process in which a protein is maintained in a specific location at the spindle pole body, and is prevented from moving elsewhere. [GOC:mah, GOC:vw]"}
{"concept_id": "C3156205", "aliases": [], "types": ["T043"], "canonical_name": "phytochelatin transport", "definition": "The directed movement of a phytochelatin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C3156206", "aliases": ["phytochelatin membrane transport"], "types": ["T043"], "canonical_name": "phytochelatin transmembrane transport", "definition": "The process in which a phytochelatin is transported across a membrane. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C3156207", "aliases": ["phytochelatin transport into vacuole"], "types": ["T043"], "canonical_name": "phytochelatin import into vacuole", "definition": "The directed movement of phytochelatins into the vacuole. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. [GOC:mah, ISBN:0198506732]"}
{"concept_id": "C3156208", "aliases": ["glutathione transport into vacuole"], "types": ["T043"], "canonical_name": "glutathione transmembrane import into vacuole", "definition": "The directed movement of glutathione into the vacuole across the vacuolar membrane. [GOC:mah]"}
{"concept_id": "C3156209", "aliases": [], "types": ["T044"], "canonical_name": "glutathione S-conjugate-transporting ATPase activity"}
{"concept_id": "C3156210", "aliases": ["ascospore liberation"], "types": ["T043"], "canonical_name": "ascospore release from ascus", "definition": "A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive. [DOI:10.1016/S0953-7562(96)80057-8, GOC:mah]"}
{"concept_id": "C3156211", "aliases": ["extracellular polysaccharide breakdown", "extracellular polysaccharide degradation", "extracellular polysaccharide catabolism"], "types": ["T043"], "canonical_name": "extracellular polysaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures. [GOC:mah, GOC:vw]"}
{"concept_id": "C3156212", "aliases": ["extracellular polysaccharide catabolism involved in ascospore release from ascus", "extracellular polysaccharide degradation involved in ascospore release from ascus", "extracellular polysaccharide breakdown involved in ascospore release from ascus"], "types": ["T043"], "canonical_name": "extracellular polysaccharide catabolic process involved in ascospore release from ascus", "definition": "The chemical reactions and pathways resulting in the breakdown of polysaccharides in the ascus wall that contributes to the release of ascospores from the ascus. [GOC:mah, GOC:vw]"}
{"concept_id": "C3156213", "aliases": [], "types": ["T043"], "canonical_name": "ascus catabolic process"}
{"concept_id": "C3156214", "aliases": [], "types": ["T043"], "canonical_name": "ascus endolysis"}
{"concept_id": "C3156215", "aliases": [], "types": ["T038"], "canonical_name": "urinary system development"}
{"concept_id": "C3156216", "aliases": [], "types": ["T038"], "canonical_name": "urinary tract development"}
{"concept_id": "C3156218", "aliases": [], "types": ["T043"], "canonical_name": "metanephric renal vesicle induction", "definition": "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156219", "aliases": [], "types": ["T042"], "canonical_name": "anterior/posterior pattern specification involved in ureteric bud development", "definition": "The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156229", "aliases": [], "types": ["T042"], "canonical_name": "metanephric juxtamedullary nephron development"}
{"concept_id": "C3156230", "aliases": [], "types": ["T043"], "canonical_name": "metanephric extraglomerular mesangial cell proliferation involved in metanephros development", "definition": "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156231", "aliases": [], "types": ["T043"], "canonical_name": "metanephric glomerular basement membrane development", "definition": "The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156232", "aliases": [], "types": ["T042"], "canonical_name": "metanephric glomerulus morphogenesis", "definition": "The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156233", "aliases": [], "types": ["T042"], "canonical_name": "metanephric glomerulus vasculature morphogenesis", "definition": "The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156234", "aliases": [], "types": ["T042"], "canonical_name": "metanephric glomerular capillary formation", "definition": "The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156235", "aliases": [], "types": ["T042"], "canonical_name": "metanephric comma-shaped body morphogenesis", "definition": "The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156236", "aliases": [], "types": ["T042"], "canonical_name": "convergent extension involved in metanephric nephron morphogenesis", "definition": "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156237", "aliases": [], "types": ["T042"], "canonical_name": "establishment of planar polarity involved in metanephric nephron morphogenesis", "definition": "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156238", "aliases": [], "types": ["T042"], "canonical_name": "establishment of planar cell polarity involved in metanephric nephron morphogenesis"}
{"concept_id": "C3156239", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156240", "aliases": [], "types": ["T042"], "canonical_name": "metanephric nephron tubule morphogenesis", "definition": "The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156241", "aliases": [], "types": ["T042"], "canonical_name": "metanephric renal vesicle morphogenesis", "definition": "The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156242", "aliases": [], "types": ["T042"], "canonical_name": "metanephric S-shaped body morphogenesis", "definition": "The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156243", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal to epithelial transition involved in metanephric renal vesicle formation", "definition": "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156244", "aliases": ["metanephric connecting duct development"], "types": ["T042"], "canonical_name": "metanephric connecting tubule development", "definition": "The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156245", "aliases": [], "types": ["T042"], "canonical_name": "metanephric distal tubule morphogenesis", "definition": "The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156246", "aliases": [], "types": ["T042"], "canonical_name": "metanephric proximal tubule morphogenesis", "definition": "The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156247", "aliases": [], "types": ["T042"], "canonical_name": "metanephric nephron tubule formation", "definition": "The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156248", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration involved in metanephric nephron tubule morphogenesis", "definition": "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156249", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration involved in metanephric distal tubule morphogenesis", "definition": "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric distal tubule morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156250", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell migration involved in metanephric proximal tubule morphogenesis", "definition": "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric proximal tubule morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156251", "aliases": [], "types": ["T042"], "canonical_name": "specification of metanephric nephron tubule identity", "definition": "The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156252", "aliases": [], "types": ["T042"], "canonical_name": "specification of metanephric connecting tubule identity", "definition": "The process in which the connecting tubule of the metanephric nephron acquires its identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156253", "aliases": [], "types": ["T042"], "canonical_name": "specification of metanephric distal tubule identity", "definition": "The process in which the distal tubule of the metanephric nephron acquires its identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156254", "aliases": ["specification of metanephric intermediate tubule identity"], "types": ["T042"], "canonical_name": "specification of metanephric loop of Henle identity", "definition": "The process in which the loop of Henle of the metanephric nephron acquires its identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156255", "aliases": [], "types": ["T042"], "canonical_name": "specification of metanephric proximal tubule identity", "definition": "The process in which the proximal tubule of the metanephric nephron acquires its identity. [GOC:bf, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156256", "aliases": [], "types": ["T042"], "canonical_name": "regulation of metanephric glomerulus development", "definition": "Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156257", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of metanephric glomerulus development", "definition": "Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156258", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of metanephric glomerulus development", "definition": "Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156259", "aliases": [], "types": ["T043"], "canonical_name": "regulation of metanephric glomerular mesangial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156260", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of metanephric glomerular mesangial cell proliferation", "definition": "Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156261", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glomerular metanephric mesangial cell proliferation", "definition": "Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156262", "aliases": ["regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis", "regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis"], "types": ["T038"], "canonical_name": "regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis", "definition": "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156263", "aliases": ["negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis", "negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis"], "types": ["T038"], "canonical_name": "negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis", "definition": "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156264", "aliases": ["positive regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis", "positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis"], "types": ["T038"], "canonical_name": "positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis", "definition": "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156265", "aliases": [], "types": ["T043"], "canonical_name": "regulation of metanephric nephron tubule epithelial cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156266", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of metanephric nephron tubule epithelial cell differentiation", "definition": "Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156267", "aliases": [], "types": ["T040"], "canonical_name": "mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis", "definition": "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156268", "aliases": [], "types": ["T043"], "canonical_name": "glomerular epithelial cell development", "definition": "The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156269", "aliases": [], "types": ["T043"], "canonical_name": "glomerular epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156270", "aliases": [], "types": ["T043"], "canonical_name": "metanephric glomerular epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156271", "aliases": [], "types": ["T043"], "canonical_name": "metanephric glomerular epithelial cell development", "definition": "The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156272", "aliases": [], "types": ["T043"], "canonical_name": "glomerular epithelial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156273", "aliases": [], "types": ["T043"], "canonical_name": "metanephric glomerular epithelial cell fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3156274", "aliases": ["alpha-glucan catabolism involved in ascospore release from ascus", "alpha-glucan degradation involved in ascospore release from ascus", "alpha-glucan breakdown involved in ascospore release from ascus"], "types": ["T044"], "canonical_name": "alpha-glucan catabolic process involved in ascospore release from ascus", "definition": "The chemical reactions and pathways resulting in the breakdown of alpha-glucans in the ascus wall that contributes to the release of ascospores from the ascus. [GOC:mah]"}
{"concept_id": "C3156276", "aliases": ["clathrin-coat uncoating", "clathrin-coat disassembly", "clathrin-coated vesicle uncoating"], "types": ["T044"], "canonical_name": "clathrin coat disassembly", "definition": "The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system. [PMID:11084334, PMID:11146663, PMID:8524399]"}
{"concept_id": "C3156277", "aliases": ["vesicle coat disassembly"], "types": ["T044"], "canonical_name": "vesicle uncoating", "definition": "A protein depolymerization process that results in the disassembly of vesicle coat proteins. [GOC:mah]"}
{"concept_id": "C3156278", "aliases": [], "types": ["T044"], "canonical_name": "volume-sensitive chloride channel activity", "definition": "Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. [GOC:mah]"}
{"concept_id": "C3156280", "aliases": [], "types": ["T043"], "canonical_name": "protein transport across periplasmic space", "definition": "The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane or cell wall. [GOC:mah, PMID:20378773]"}
{"concept_id": "C3156282", "aliases": [], "types": ["T026"], "canonical_name": "ascus epiplasm", "definition": "Ascus cytoplasm that is not packaged into ascospores. [DOI:10.1016/S0953-7562(96)80057-8, GOC:mcc]"}
{"concept_id": "C3156283", "aliases": [], "types": ["T043"], "canonical_name": "vulval cell fate commitment", "definition": "The process in which the cellular identity of nematode vulval cells is acquired and determined. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes. [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714]"}
{"concept_id": "C3156284", "aliases": [], "types": ["T043"], "canonical_name": "vulval cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell regardless of its environment; upon determination, the cell fate cannot be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes. [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714]"}
{"concept_id": "C3156285", "aliases": [], "types": ["T043"], "canonical_name": "vulval cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes. [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714]"}
{"concept_id": "C3156286", "aliases": [], "types": ["T044"], "canonical_name": "alkene binding", "definition": "Binding to an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n. [GOC:mah]"}
{"concept_id": "C3156287", "aliases": [], "types": ["T044"], "canonical_name": "monocarboxylic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. [GOC:mah]"}
{"concept_id": "C3156288", "aliases": ["monocarboxylic acid formation", "monocarboxylic acid biosynthesis", "monocarboxylic acid anabolism", "monocarboxylic acid synthesis"], "types": ["T044"], "canonical_name": "monocarboxylic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. [GOC:mah]"}
{"concept_id": "C3156289", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction by p53 class mediator", "definition": "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. [GOC:mah]"}
{"concept_id": "C3156290", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3156292", "aliases": ["UDP-galactose membrane transport"], "types": ["T043"], "canonical_name": "UDP-galactose transmembrane transport", "definition": "The process in which UDP-galactose is transported across a membrane. [GOC:mah]"}
{"concept_id": "C3156293", "aliases": ["regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation", "regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation", "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation", "regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation"], "types": ["T043"], "canonical_name": "regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation", "definition": "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dgh]"}
{"concept_id": "C3156294", "aliases": ["negative regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation", "negative regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation", "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation", "definition": "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dgh]"}
{"concept_id": "C3156295", "aliases": ["amino acid derivative transport"], "types": ["T043"], "canonical_name": "modified amino acid transport", "definition": "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C3156296", "aliases": ["cellular lactam metabolism"], "types": ["T044"], "canonical_name": "cellular lactam metabolic process", "definition": "The chemical reactions and pathways involving lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. [GOC:mah]"}
{"concept_id": "C3156297", "aliases": ["cellular lactam synthesis", "cellular lactam formation", "cellular lactam biosynthesis", "cellular lactam anabolism"], "types": ["T044"], "canonical_name": "cellular lactam biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. [GOC:mah]"}
{"concept_id": "C3156298", "aliases": ["cellular lactam catabolism", "cellular lactam breakdown", "cellular lactam degradation"], "types": ["T044"], "canonical_name": "cellular lactam catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. [GOC:mah]"}
{"concept_id": "C3156299", "aliases": ["amino acid derivative binding"], "types": ["T044"], "canonical_name": "modified amino acid binding", "definition": "Binding to a modified amino acid. [GOC:mah]"}
{"concept_id": "C3156300", "aliases": [], "types": ["T043"], "canonical_name": "response to anion stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of anion stress, an increase or decrease in the concentration of negatively charged ions in the environment. [GOC:cvs, PMID:19641131]"}
{"concept_id": "C3156301", "aliases": [], "types": ["T043"], "canonical_name": "pancreatic stellate cell proliferation", "definition": "The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus. [CL:0002410, GOC:mah, PMID:17200706]"}
{"concept_id": "C3156302", "aliases": [], "types": ["T045"], "canonical_name": "rescue of stalled ribosome", "definition": "A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex. [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543]"}
{"concept_id": "C3156303", "aliases": [], "types": ["T044"], "canonical_name": "NAADP-sensitive calcium-release channel activity", "definition": "Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts. [PMID:19387438, PMID:19557428]"}
{"concept_id": "C3156304", "aliases": [], "types": ["T044"], "canonical_name": "cADPR-sensitive calcium-release channel activity", "definition": "Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts. [PMID:11752598]"}
{"concept_id": "C3156305", "aliases": ["response to anaesthetic"], "types": ["T043"], "canonical_name": "response to anesthetic", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation. [GOC:sart]"}
{"concept_id": "C3156306", "aliases": ["sulfur-containing compound transport"], "types": ["T043"], "canonical_name": "sulfur compound transport", "definition": "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C3156307", "aliases": ["amino acid derivative transmembrane transporter activity"], "types": ["T044"], "canonical_name": "modified amino acid transmembrane transporter activity", "definition": "Enables the transfer of modified amino acids from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C3156308", "aliases": [], "types": ["T044"], "canonical_name": "modified amino acid transporter activity"}
{"concept_id": "C3156309", "aliases": ["tricarboxylic acid metabolism"], "types": ["T044"], "canonical_name": "tricarboxylic acid metabolic process", "definition": "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). [GOC:mah]"}
{"concept_id": "C3156310", "aliases": ["tricarboxylic acid anabolism", "tricarboxylic acid formation", "tricarboxylate biosynthesis", "tricarboxylate biosynthetic process", "tricarboxylic acid biosynthesis", "tricarboxylic acid synthesis"], "types": ["T044"], "canonical_name": "tricarboxylic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups. [GOC:mah]"}
{"concept_id": "C3156311", "aliases": ["tricarboxylate catabolic process", "tricarboxylate catabolism", "tricarboxylic acid degradation", "tricarboxylic acid breakdown", "tricarboxylic acid catabolism"], "types": ["T044"], "canonical_name": "tricarboxylic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups. [GOC:mah]"}
{"concept_id": "C3156313", "aliases": ["histone-threonine kinase activity (H3-T3 specific)", "histone threonine kinase activity (H3-T3 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H3-T3 specific)", "definition": "Catalysis of the transfer of a phosphate group to the threonine-3 residue of the N-terminal tail of histone H3. [GOC:mah]"}
{"concept_id": "C3156314", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-T3 phosphorylation", "definition": "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 3 of the histone. [GOC:mah]"}
{"concept_id": "C3156315", "aliases": ["chromosome passenger complex localisation to kinetochore", "CPC complex localization to kinetochore", "chromosomal passenger complex localization to kinetochore", "CPC localization to kinetochore"], "types": ["T043"], "canonical_name": "chromosome passenger complex localization to kinetochore", "definition": "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. [GOC:mah]"}
{"concept_id": "C3156317", "aliases": ["PTW/PP1 phosphatase complex location"], "types": ["T026"], "canonical_name": "PTW/PP1 phosphatase complex", "definition": "A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. [GOC:mah, PMID:20516061]"}
{"concept_id": "C3156319", "aliases": [], "types": ["T038"], "canonical_name": "circulatory system development", "definition": "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. [GOC:mah, UBERON:0001009]"}
{"concept_id": "C3156320", "aliases": [], "types": ["T042"], "canonical_name": "vascular cord development", "definition": "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. [GOC:mah, PMID:7084422, ZFA:0005077]"}
{"concept_id": "C3156330", "aliases": ["histone H2A phosphorylation at S121", "histone H2AS121 phosphorylation"], "types": ["T044"], "canonical_name": "histone H2A-S121 phosphorylation", "definition": "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 121 of the histone. [GOC:mah, PMID:19965387]"}
{"concept_id": "C3156331", "aliases": ["histone-serine kinase activity (H2A-S121 specific)", "histone serine kinase activity (H2A-S121 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H2A-S121 specific)", "definition": "Catalysis of the transfer of a phosphate group to the serine-121 residue of the N-terminal tail of histone H2A. [GOC:mah, PMID:19965387]"}
{"concept_id": "C3156332", "aliases": [], "types": ["T026"], "canonical_name": "primary cilium"}
{"concept_id": "C3156333", "aliases": [], "types": ["T044"], "canonical_name": "alpha-carotene epsilon hydroxylase activity", "definition": "Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O. [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962]"}
{"concept_id": "C3156334", "aliases": [], "types": ["T044"], "canonical_name": "carotene epsilon hydroxylase activity", "definition": "Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene. [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962]"}
{"concept_id": "C3156335", "aliases": ["MTM", "medium-term memory"], "types": ["T041"], "definition": "The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster). [GOC:sart, PMID:14659098, PMID:7923375]", "canonical_name": "middle-term memory"}
{"concept_id": "C3156336", "aliases": ["protein activation cascade", "protein activitory cascade"], "types": ["T044"], "definition": "A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events. [GOC:add, GOC:mah, GOC:pde]", "canonical_name": "protein activation pathway"}
{"concept_id": "C3156337", "aliases": [], "types": ["T044"], "canonical_name": "blood coagulation, common pathway", "definition": "A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex. [GOC:add, GOC:mah, GOC:pde, PMID:1931959]"}
{"concept_id": "C3156338", "aliases": [], "types": ["T044"], "canonical_name": "blood coagulation, fibrin clot formation", "definition": "A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. [GOC:add, GOC:mah, GOC:pde]"}
{"concept_id": "C3156339", "aliases": ["endoplasmic reticulum membrane insertion complex", "ER membrane insertion complex location", "endoplasmic reticulum membrane insertion complex location"], "types": ["T026"], "canonical_name": "ER membrane insertion complex", "definition": "A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast. [GOC:mah, PMID:20676083, PMID:20850366]"}
{"concept_id": "C3156340", "aliases": ["TMD recognition complex", "TRC complex location", "TMD recognition complex location"], "types": ["T026"], "canonical_name": "TRC complex", "definition": "A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane. [GOC:mah, PMID:20850366, PMID:23142665]"}
{"concept_id": "C3156341", "aliases": ["positive regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation", "positive regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation", "positive regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation", "positive regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation", "definition": "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:mah]"}
{"concept_id": "C3156342", "aliases": ["microtubule minus-end-directed vesicle localization"], "types": ["T043"], "canonical_name": "minus-end-directed vesicle transport along microtubule", "definition": "The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156343", "aliases": [], "types": ["T043"], "canonical_name": "microtubule minus-end-directed vesicle distribution"}
{"concept_id": "C3156344", "aliases": ["microtubule plus-end-directed vesicle localization"], "types": ["T043"], "canonical_name": "plus-end-directed vesicle transport along microtubule", "definition": "The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156345", "aliases": [], "types": ["T043"], "canonical_name": "microtubule plus-end-directed vesicle distribution"}
{"concept_id": "C3156346", "aliases": ["microtubule-based organelle localization"], "types": ["T043"], "canonical_name": "organelle transport along microtubule", "definition": "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. [GOC:mah]"}
{"concept_id": "C3156347", "aliases": ["microtubule minus-end-directed organelle localization"], "types": ["T043"], "canonical_name": "minus-end-directed organelle transport along microtubule", "definition": "The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156348", "aliases": [], "types": ["T043"], "canonical_name": "microtubule minus-end-directed organelle distribution"}
{"concept_id": "C3156349", "aliases": ["microtubule plus-end-directed organelle localization"], "types": ["T043"], "canonical_name": "plus-end-directed organelle transport along microtubule", "definition": "The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156350", "aliases": [], "types": ["T043"], "canonical_name": "microtubule plus-end-directed organelle distribution"}
{"concept_id": "C3156351", "aliases": ["FAD or FADH2 metabolic process", "flavin adenine dinucleotide metabolism", "flavin-adenine dinucleotide metabolic process"], "types": ["T044"], "canonical_name": "flavin adenine dinucleotide metabolic process", "definition": "The chemical reactions and pathways involving flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]"}
{"concept_id": "C3156352", "aliases": ["flavin adenine dinucleotide formation", "flavin adenine dinucleotide anabolism", "FAD or FADH2 biosynthetic process", "flavin adenine dinucleotide synthesis", "flavin adenine dinucleotide biosynthesis"], "types": ["T044"], "canonical_name": "flavin adenine dinucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]"}
{"concept_id": "C3156353", "aliases": ["flavin adenine dinucleotide breakdown", "flavin adenine dinucleotide catabolism", "flavin adenine dinucleotide degradation", "FAD or FADH2 catabolic process"], "types": ["T044"], "canonical_name": "flavin adenine dinucleotide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]"}
{"concept_id": "C3156354", "aliases": [], "types": ["T044"], "canonical_name": "phenol metabolic process", "definition": "The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group. [GOC:mah]"}
{"concept_id": "C3156355", "aliases": ["microtubule anchoring at microtubule organising centre", "microtubule anchoring at MTOC"], "types": ["T043"], "canonical_name": "microtubule anchoring at microtubule organizing center", "definition": "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center. [GOC:BHF, PMID:19825938]"}
{"concept_id": "C3156361", "aliases": ["cell cycle checkpoint effector process", "response to signal involved in cell cycle checkpoint"], "types": ["T043"], "canonical_name": "response to cell cycle checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156366", "aliases": [], "types": ["T043"], "definition": "A signal transduction process that contributes to a cytokinesis checkpoint. [GOC:mtg_cell_cycle]", "canonical_name": "signal transduction involved in cytokinesis checkpoint"}
{"concept_id": "C3156367", "aliases": ["response to signal involved in cytokinesis checkpoint", "cytokinesis checkpoint effector process"], "types": ["T043"], "canonical_name": "response to cytokinesis checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of cytokinesis checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156373", "aliases": ["DNA integrity checkpoint effector process", "response to signal involved in DNA integrity checkpoint"], "types": ["T043"], "canonical_name": "response to DNA integrity checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156379", "aliases": ["response to signal involved in G1/S transition checkpoint"], "types": ["T043"], "canonical_name": "G1/S transition checkpoint effector process"}
{"concept_id": "C3156385", "aliases": ["response to signal involved in G2/M transition checkpoint"], "types": ["T043"], "canonical_name": "G2/M transition checkpoint effector process"}
{"concept_id": "C3156390", "aliases": ["response to signal involved in meiotic cell cycle checkpoint", "meiotic cell cycle checkpoint effector process"], "types": ["T043"], "canonical_name": "response to meiotic cell cycle checkpoint signaling", "definition": "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint. [GOC:mah]"}
{"concept_id": "C3156397", "aliases": ["response to signal involved in mitotic cell cycle checkpoint", "mitotic cell cycle checkpoint effector process"], "types": ["T043"], "canonical_name": "response to mitotic cell cycle checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156403", "aliases": ["response to signal involved in spindle checkpoint", "spindle checkpoint effector process"], "types": ["T043"], "canonical_name": "response to spindle checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of spindle checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156415", "aliases": ["DNA damage checkpoint effector process", "response to signal involved in DNA damage checkpoint"], "types": ["T043"], "canonical_name": "response to DNA damage checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156421", "aliases": ["G2/M transition DNA damage checkpoint effector process", "response to signal involved in G2/M transition DNA damage checkpoint"], "types": ["T043"], "canonical_name": "response to G2 DNA damage checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156427", "aliases": ["response to signal involved in intra-S DNA damage checkpoint", "intra-S DNA damage checkpoint effector process"], "types": ["T043"], "canonical_name": "response to intra-S DNA damage checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156433", "aliases": ["response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint", "response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling", "mitotic cell cycle G1/S transition DNA damage checkpoint effector process"], "types": ["T043"], "canonical_name": "response to G1 DNA damage checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of G1/S transition DNA damage checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156439", "aliases": ["response to mitotic G2/M transition DNA damage checkpoint signaling", "mitotic G2/M transition DNA damage checkpoint effector process", "response to signal involved in mitotic G2/M transition DNA damage checkpoint"], "types": ["T043"], "canonical_name": "response to mitotic G2 DNA damage checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156445", "aliases": ["response to signal involved in DNA replication checkpoint", "DNA replication checkpoint effector process"], "types": ["T043"], "canonical_name": "response to DNA replication checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of DNA replication checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156451", "aliases": ["response to signal involved in meiotic DNA replication checkpoint", "meiotic DNA replication checkpoint effector process"], "types": ["T043"], "canonical_name": "response to meiotic DNA replication checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156460", "aliases": ["response to S-M checkpoint signaling", "S-M checkpoint effector process", "response to signal involved in S-M checkpoint", "mitotic DNA replication checkpoint effector process", "response to signal involved in mitotic DNA replication checkpoint"], "types": ["T043"], "canonical_name": "response to mitotic DNA replication checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of mitotic DNA replication checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156465", "aliases": ["response to signal involved in mitotic cell cycle G1/S transition size control checkpoint", "mitotic cell cycle G1/S transition size control checkpoint effector process"], "types": ["T043"], "canonical_name": "response to G1 cell size control checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156472", "aliases": ["G2/M transition size control checkpoint effector process", "response to G2/M transition size control checkpoint signaling", "response to mitotic cell cycle G2/M transition size control checkpoint signaling", "response to signal involved in G2/M transition size control checkpoint"], "types": ["T043"], "canonical_name": "response to G2 transition size control checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of G2/M transition size control checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156478", "aliases": ["response to mitotic G2/M transition checkpoint signal", "response to signal involved in mitotic G2/M transition checkpoint"], "types": ["T043"], "canonical_name": "mitotic G2/M transition checkpoint effector process"}
{"concept_id": "C3156484", "aliases": ["response to signal involved in mitotic G2/M transition decatenation checkpoint"], "types": ["T043"], "canonical_name": "mitotic G2/M transition decatenation checkpoint effector process"}
{"concept_id": "C3156490", "aliases": ["response to signal involved in meiotic recombination checkpoint", "meiotic recombination checkpoint effector process"], "types": ["T043"], "canonical_name": "response to meiotic recombination checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of meiotic recombination checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156496", "aliases": ["meiotic spindle assembly checkpoint effector process", "response to signal involved in meiotic spindle assembly checkpoint"], "types": ["T043"], "canonical_name": "response to meiotic spindle assembly checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156508", "aliases": ["cell size control checkpoint effector process", "response to signal involved in cell size control checkpoint", "response to mitotic cell cycle cell size control checkpoint signaling"], "types": ["T043"], "canonical_name": "response to cell size control checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of cell size control checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156514", "aliases": ["response to signal involved in mitotic cell cycle G1/S checkpoint"], "types": ["T043"], "canonical_name": "mitotic cell cycle G1/S checkpoint effector process"}
{"concept_id": "C3156520", "aliases": ["response to signal involved in mitotic cell cycle spindle checkpoint", "mitotic cell cycle spindle checkpoint effector process", "response to mitotic cell cycle spindle checkpoint signaling"], "types": ["T043"], "canonical_name": "response to mitotic spindle checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156526", "aliases": ["response to signal involved in mitotic cell cycle spindle assembly checkpoint", "mitotic cell cycle spindle assembly checkpoint effector process"], "types": ["T043"], "canonical_name": "response to mitotic cell cycle spindle assembly checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle assembly checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156532", "aliases": ["mitotic cell cycle spindle orientation checkpoint effector process", "response to signal involved in mitotic cell cycle spindle orientation checkpoint"], "types": ["T043"], "canonical_name": "response to mitotic cell cycle spindle orientation checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156538", "aliases": ["spindle assembly checkpoint effector process", "response to signal involved in spindle assembly checkpoint"], "types": ["T043"], "canonical_name": "response to spindle assembly checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of spindle assembly checkpoint signaling. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3156540", "aliases": ["MSL complex location"], "types": ["T026"], "canonical_name": "MSL complex", "definition": "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3. [PMID:16227571, PMID:20018852]"}
{"concept_id": "C3156541", "aliases": ["ammonium membrane transport"], "types": ["T043"], "canonical_name": "ammonium transmembrane transport", "definition": "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. [GOC:mah]"}
{"concept_id": "C3156542", "aliases": ["methylammonium membrane transport"], "types": ["T043"], "canonical_name": "methylammonium transmembrane transport", "definition": "The process in which methylammonium is transported across a membrane. [GOC:mah]"}
{"concept_id": "C3156543", "aliases": ["toluene and derivative metabolic process", "toluene-containing compound metabolism"], "types": ["T044"], "canonical_name": "toluene-containing compound metabolic process", "definition": "The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives. [GOC:mah]"}
{"concept_id": "C3156544", "aliases": ["toluene-containing compound degradation", "toluene-containing compound breakdown", "toluene and derivative catabolic process", "toluene-containing compound catabolism"], "types": ["T044"], "canonical_name": "toluene-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives. [GOC:mah]"}
{"concept_id": "C3156545", "aliases": [], "types": ["T026"], "canonical_name": "host cell mitochondrial intermembrane space", "definition": "The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope. [GOC:ecd]"}
{"concept_id": "C3156546", "aliases": ["host endosome lumen"], "types": ["T026"], "canonical_name": "host cell endosome lumen", "definition": "The volume enclosed by the membranes of the host cell endosome. [GOC:ecd]"}
{"concept_id": "C3156547", "aliases": ["host cell multivesicular body"], "types": ["T026"], "canonical_name": "host multivesicular body", "definition": "A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm. [GOC:rph]"}
{"concept_id": "C3156548", "aliases": ["host cell coiled body", "coiled body of host"], "types": ["T026"], "canonical_name": "host cell Cajal body", "definition": "A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction. [GOC:rph]"}
{"concept_id": "C3156549", "aliases": ["Pup conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y -> Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C3156550", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal stem cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [CL:0002452, GOC:BHF]"}
{"concept_id": "C3156551", "aliases": [], "types": ["T040"], "canonical_name": "embryonic skeletal joint development", "definition": "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. [GOC:BHF, GOC:vk]"}
{"concept_id": "C3156552", "aliases": ["photoreceptor cell axon pathfinding"], "types": ["T043"], "canonical_name": "photoreceptor cell axon guidance", "definition": "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues. [GOC:sart, PMID:20826677]"}
{"concept_id": "C3156554", "aliases": [], "types": ["T043"], "canonical_name": "cellular divalent inorganic anion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell. [GOC:mah]"}
{"concept_id": "C3156555", "aliases": [], "types": ["T043"], "canonical_name": "cellular trivalent inorganic anion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell. [GOC:mah]"}
{"concept_id": "C3156556", "aliases": [], "types": ["T043"], "canonical_name": "cellular divalent inorganic cation homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell. [GOC:mah]"}
{"concept_id": "C3156557", "aliases": [], "types": ["T043"], "canonical_name": "cellular trivalent inorganic cation homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of trivalent cations at the level of a cell. [GOC:mah]"}
{"concept_id": "C3156558", "aliases": [], "types": ["T039"], "canonical_name": "divalent inorganic anion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. [GOC:mah]"}
{"concept_id": "C3156559", "aliases": [], "types": ["T039"], "canonical_name": "trivalent inorganic anion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell. [GOC:mah]"}
{"concept_id": "C3156560", "aliases": [], "types": ["T039"], "canonical_name": "divalent inorganic cation homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. [GOC:mah]"}
{"concept_id": "C3156561", "aliases": [], "types": ["T039"], "canonical_name": "trivalent inorganic cation homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of trivalent cations within an organism or cell. [GOC:mah]"}
{"concept_id": "C3156566", "aliases": ["negative regulation of second heart field cardioblast proliferation"], "types": ["T043"], "canonical_name": "positive regulation of secondary heart field cardioblast proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract). [GOC:BHF, GOC:mah, GOC:rl]"}
{"concept_id": "C3156567", "aliases": [], "types": ["T043"], "canonical_name": "trehalose transport in response to water deprivation", "definition": "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water. [GOC:mah]"}
{"concept_id": "C3156568", "aliases": [], "types": ["T043"], "canonical_name": "trehalose transport in response to desiccation", "definition": "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water. [GOC:mah]"}
{"concept_id": "C3156571", "aliases": ["host cell virion assembly compartment", "viral assembly compartment", "virion assembly compartment"], "types": ["T026"], "canonical_name": "host cell viral assembly compartment", "definition": "A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place. [GOC:BHF, PMID:20374631]"}
{"concept_id": "C3156572", "aliases": [], "types": ["T026"], "canonical_name": "host cell viral assembly site"}
{"concept_id": "C3156573", "aliases": ["Rho-associated protein kinase activity", "ROCK kinase activity"], "types": ["T044"], "canonical_name": "Rho-dependent protein serine/threonine kinase activity", "definition": "Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:ecd, PMID:12778124, PMID:20230755]"}
{"concept_id": "C3156574", "aliases": [], "types": ["T040"], "canonical_name": "seminiferous tubule development", "definition": "The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa. [GOC:BHF, GOC:mah, UBERON:0001343]"}
{"concept_id": "C3156575", "aliases": ["purine and derivative metabolic process", "purine-containing compound metabolism"], "types": ["T040"], "canonical_name": "purine-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156576", "aliases": ["purine-containing compound synthesis", "purine-containing compound biosynthesis", "purine and derivative biosynthetic process", "purine-containing compound anabolism", "purine-containing compound formation"], "types": ["T044"], "canonical_name": "purine-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156577", "aliases": ["purine and derivative catabolic process", "purine-containing compound catabolism", "purine-containing compound breakdown", "purine-containing compound degradation"], "types": ["T044"], "canonical_name": "purine-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156578", "aliases": ["pyridine and derivative metabolic process", "pyridine-containing compound metabolism"], "types": ["T040"], "canonical_name": "pyridine-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156579", "aliases": ["pyridine-containing compound synthesis", "pyridine and derivative biosynthetic process", "pyridine-containing compound biosynthesis", "pyridine-containing compound formation", "pyridine-containing compound anabolism"], "types": ["T044"], "canonical_name": "pyridine-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156580", "aliases": ["pyridine-containing compound breakdown", "pyridine-containing compound degradation", "pyridine and derivative catabolic process", "pyridine-containing compound catabolism"], "types": ["T044"], "canonical_name": "pyridine-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156581", "aliases": ["pyrimidine and derivative metabolic process", "pyrimidine-containing compound metabolism"], "types": ["T040"], "canonical_name": "pyrimidine-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156582", "aliases": ["pyrimidine-containing compound formation", "pyrimidine-containing compound anabolism", "pyrimidine-containing compound biosynthesis", "pyrimidine-containing compound synthesis", "pyrimidine and derivative biosynthetic process"], "types": ["T044"], "canonical_name": "pyrimidine-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156583", "aliases": ["pyrimidine-containing compound breakdown", "pyrimidine and derivative catabolic process", "pyrimidine-containing compound degradation", "pyrimidine-containing compound catabolism"], "types": ["T044"], "canonical_name": "pyrimidine-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156584", "aliases": ["purine-containing compound membrane transport"], "types": ["T043"], "canonical_name": "purine-containing compound transmembrane transport", "definition": "The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156585", "aliases": ["pyrimidine-containing compound membrane transport"], "types": ["T043"], "canonical_name": "pyrimidine-containing compound transmembrane transport", "definition": "The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]"}
{"concept_id": "C3156586", "aliases": [], "types": ["T044"], "canonical_name": "tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity", "definition": "Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives. [GOC:kad, PMID:19779199]"}
{"concept_id": "C3156587", "aliases": [], "types": ["T044"], "canonical_name": "tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity", "definition": "Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives. [GOC:kad, PMID:19779199]"}
{"concept_id": "C3156588", "aliases": ["PNN"], "types": ["T026"], "definition": "A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain. [GOC:sl, PMID:18364019]", "canonical_name": "perineuronal net"}
{"concept_id": "C3156589", "aliases": ["TNFSF11 production", "RANKL production", "tumor necrosis factor ligand superfamily member 11 production"], "types": ["T044"], "canonical_name": "tumor necrosis factor (ligand) superfamily member 11 production", "definition": "The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156590", "aliases": ["IL-23 receptor complex location", "IL-23 receptor complex", "interleukin-23 receptor complex location"], "types": ["T026"], "definition": "A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits. [GOC:BHF, GOC:mah, PMID:12023369]", "canonical_name": "interleukin-23 receptor complex"}
{"concept_id": "C3156591", "aliases": [], "types": ["T043"], "canonical_name": "fibroblast activation", "definition": "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. [CL:0000057, GOC:BHF, GOC:mah]"}
{"concept_id": "C3156592", "aliases": ["Th17 immune response"], "types": ["T040"], "canonical_name": "T-helper 17 type immune response", "definition": "An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22. [GOC:BHF, GOC:ebc]"}
{"concept_id": "C3156593", "aliases": [], "types": ["T043"], "canonical_name": "T-helper 17 cell differentiation", "definition": "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. [CL:0000899, GOC:BHF, GOC:ebc]"}
{"concept_id": "C3156594", "aliases": [], "types": ["T043"], "canonical_name": "T-helper 17 cell development"}
{"concept_id": "C3156595", "aliases": ["T-helper 17 cell fate commitment", "Th17 cell lineage commitment", "Th17 fate commitment"], "types": ["T043"], "canonical_name": "T-helper 17 cell lineage commitment", "definition": "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. [CL:0000899, GOC:BHF, GOC:ebc]"}
{"concept_id": "C3156596", "aliases": ["peroxynitritase activity"], "types": ["T044"], "canonical_name": "peroxynitrite reductase activity", "definition": "Catalysis of the reaction: [protein]-dithiol + ONOO- = [protein]-disulfide + NO2- + H2O. [GOC:rs, PMID:11001062]"}
{"concept_id": "C3156597", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase activator activity", "definition": "Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. [GOC:mah]"}
{"concept_id": "C3156598", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 2A activator activity"}
{"concept_id": "C3156599", "aliases": [], "types": ["T044"], "canonical_name": "L-DOPA binding", "definition": "Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid. [GOC:mah, GOC:vw]"}
{"concept_id": "C3156600", "aliases": ["Tyr binding"], "types": ["T044"], "canonical_name": "tyrosine binding", "definition": "Binding to 2-amino-3-(4-hydroxyphenyl)propanoic acid. [GOC:mah]"}
{"concept_id": "C3156601", "aliases": ["ER membrane protein complex location", "ER membrane protein complex", "endoplasmic reticulum membrane protein complex"], "types": ["T026"], "canonical_name": "endoplasmic reticulum membrane protein complex location"}
{"concept_id": "C3156602", "aliases": ["tricoumaroyl spermidine meta-hydroxylase activity"], "types": ["T044"], "canonical_name": "tricoumaroylspermidine meta-hydroxylase activity", "definition": "Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O. [GOC:kad, PMID:19779199]"}
{"concept_id": "C3156603", "aliases": [], "types": ["T044"], "canonical_name": "dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity", "definition": "Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O. [GOC:kad, PMID:19779199]"}
{"concept_id": "C3156604", "aliases": [], "types": ["T044"], "canonical_name": "monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity", "definition": "Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O. [GOC:kad, PMID:19779199]"}
{"concept_id": "C3156605", "aliases": ["triferuloyl spermidine meta-hydroxylase activity"], "types": ["T044"], "canonical_name": "triferuloylspermidine meta-hydroxylase activity", "definition": "Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O. [GOC:kad, PMID:19779199]"}
{"concept_id": "C3156606", "aliases": [], "types": ["T044"], "canonical_name": "diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity", "definition": "Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O. [GOC:kad, PMID:19779199]"}
{"concept_id": "C3156607", "aliases": [], "types": ["T044"], "canonical_name": "monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity", "definition": "Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O. [GOC:kad, PMID:19779199]"}
{"concept_id": "C3156608", "aliases": ["terminal bouton organization", "bouton organization", "terminal button organisation", "synaptic bouton organization", "presynaptic bouton organization"], "types": ["T043"], "canonical_name": "terminal button organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156609", "aliases": [], "types": ["T042"], "canonical_name": "blood vessel lumenization", "definition": "The process in which a developing blood vessel forms an endothelial lumen through which blood will flow. [GOC:dsf, PMID:16799567, PMID:20926893]"}
{"concept_id": "C3156610", "aliases": ["7beta-ketosteroid reductase activity", "17-beta-ketosteroid reductase (NADPH) activity"], "types": ["T044"], "canonical_name": "17-beta-ketosteroid reductase activity", "definition": "Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+. [GOC:kad, PMID:17074428]"}
{"concept_id": "C3156611", "aliases": [], "types": ["T026"], "canonical_name": "other organism presynaptic membrane"}
{"concept_id": "C3156612", "aliases": ["IPAF inflammasome complex location"], "types": ["T026"], "canonical_name": "IPAF inflammasome complex", "definition": "An inflammasome complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri. [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]"}
{"concept_id": "C3156613", "aliases": ["NALP1 inflammasome complex", "NALP1 inflammasome complex location", "NLRP1 inflammasome complex location"], "types": ["T026"], "canonical_name": "NLRP1 inflammasome complex", "definition": "An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential. [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]"}
{"concept_id": "C3156614", "aliases": ["NLRP3 inflammasome complex location", "NALP3 inflammasome complex", "NALP3 inflammasome complex location"], "types": ["T026"], "canonical_name": "NLRP3 inflammasome complex", "definition": "An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]"}
{"concept_id": "C3156615", "aliases": ["pancreatic beta cell maturation", "pancreatic B cell maturation"], "types": ["T043"], "canonical_name": "type B pancreatic cell maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. [CL:0000169, GOC:BHF]"}
{"concept_id": "C3156617", "aliases": ["cell membrane microparticle"], "types": ["T026"], "definition": "A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. [GOC:BHF, GOC:mah, PMID:16373184]", "canonical_name": "blood microparticle"}
{"concept_id": "C3156618", "aliases": [], "types": ["T026"], "definition": "A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell. [GOC:BHF, GOC:mah, PMID:16373184]", "canonical_name": "endothelial microparticle"}
{"concept_id": "C3156619", "aliases": ["microparticle release", "microparticle generation"], "types": ["T043"], "canonical_name": "blood microparticle formation", "definition": "The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. [GOC:BHF, GOC:mah, PMID:16373184]"}
{"concept_id": "C3156620", "aliases": ["endothelial microparticle release", "endothelial microparticle generation"], "types": ["T043"], "canonical_name": "endothelial microparticle formation", "definition": "The cellular component organization process in which microparticles bud off from an endothelial cell. [GOC:BHF, GOC:mah, PMID:16373184]"}
{"concept_id": "C3156621", "aliases": ["CXCL1 production", "KC production", "SCYB1 production", "keratinocyte derived chemokine production"], "types": ["T040"], "canonical_name": "chemokine (C-X-C motif) ligand 1 production", "definition": "The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156622", "aliases": ["SCYB2 production", "MIP2 production", "CXCL2 production", "MIP-2 production"], "types": ["T040"], "canonical_name": "chemokine (C-X-C motif) ligand 2 production", "definition": "The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156625", "aliases": [], "types": ["T044"], "canonical_name": "ADP-D-ribose binding", "definition": "Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment. [GOC:mah, GOC:sart, PMID:20088964]"}
{"concept_id": "C3156626", "aliases": [], "types": ["T044"], "canonical_name": "ADP-ribose binding"}
{"concept_id": "C3156627", "aliases": ["mADPr binding"], "types": ["T044"], "canonical_name": "mono-ADP-D-ribose binding", "definition": "Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment. [GOC:mah, GOC:sart, PMID:20088964]"}
{"concept_id": "C3156628", "aliases": [], "types": ["T044"], "canonical_name": "mono-ADP-ribose binding"}
{"concept_id": "C3156629", "aliases": ["pADPr binding"], "types": ["T044"], "canonical_name": "poly-ADP-D-ribose binding", "definition": "Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. [GOC:mah, GOC:sart, PMID:20088964]"}
{"concept_id": "C3156630", "aliases": [], "types": ["T044"], "canonical_name": "poly-ADP-ribose binding"}
{"concept_id": "C3156631", "aliases": ["tolerance induction to LPS"], "types": ["T038"], "canonical_name": "tolerance induction to lipopolysaccharide", "definition": "Tolerance induction directed at lipopolysaccharide antigens. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156632", "aliases": [], "types": ["T038"], "canonical_name": "tolerance induction to endotoxin"}
{"concept_id": "C3156633", "aliases": [], "types": ["T043"], "canonical_name": "hepatocyte proliferation", "definition": "The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. [CL:0000182, GOC:BHF, GOC:mah]"}
{"concept_id": "C3156634", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell proliferation involved in liver morphogenesis", "definition": "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156635", "aliases": [], "types": ["T042"], "canonical_name": "liver morphogenesis", "definition": "The process in which the anatomical structures of the liver are generated and organized. [GOC:mah]"}
{"concept_id": "C3156636", "aliases": ["programmed cell death of endothelial cells by apoptosis", "programmed cell death, endothelial cells", "endothelial cell programmed cell death by apoptosis", "killing of endothelial cells", "endothelial cell apoptosis", "apoptosis of endothelial cells"], "types": ["T043"], "canonical_name": "endothelial cell apoptotic process", "definition": "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C3156637", "aliases": [], "types": ["T044"], "canonical_name": "neurotransmitter-gated ion channel clustering", "definition": "The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane. [GOC:dsf, PMID:20843816]"}
{"concept_id": "C3156638", "aliases": [], "types": ["T044"], "canonical_name": "glycine receptor clustering", "definition": "The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane. [GOC:dsf, GOC:mah, GOC:pr, PMID:20843816]"}
{"concept_id": "C3156639", "aliases": ["EF-P modification pathway"], "types": ["T044"], "canonical_name": "bacterial-type EF-P lysine modification", "definition": "The modification of a lysine residue in a protein to produce (2S)-2-amino-6-([(3S)-3,6-diaminohexanoyl]amino)hexanoic acid, and the subsequent hydroxylation of the modified lysine residue. This modification is observed in, and is probably unique to, the prokaryotic translation elongation factor P (EF-P). [GOC:curators, GOC:imk, GOC:mah, PMID:20729861, PMID:22706199, RESID:AA0530, RESID:AA0531]"}
{"concept_id": "C3156640", "aliases": [], "types": ["T044"], "canonical_name": "protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine", "definition": "The modification of an N6-(lysyl)-L-lysine residue in a protein, producing protein-N6-(beta-lysyl)-L-lysine ((2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid). This modification is observed in, and is probably unique to, translation elongation factor P (EF-P). [GOC:jsg, GOC:mah, PMID:20729861, RESID:AA0531]"}
{"concept_id": "C3156641", "aliases": [], "types": ["T044"], "canonical_name": "17-beta-hydroxysteroid dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+. [GOC:kad, PMID:17074428]"}
{"concept_id": "C3156642", "aliases": ["clathrin coated pit-dependent endocytosis", "CME", "clathrin-mediated endocytosis"], "types": ["T043"], "canonical_name": "clathrin-dependent endocytosis", "definition": "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]"}
{"concept_id": "C3156643", "aliases": ["caveolae-dependent endocytosis", "caveolae-mediated endocytosis", "caveolin-dependent endocytosis"], "types": ["T043"], "canonical_name": "caveolin-mediated endocytosis", "definition": "An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers. [GOC:BHF, GOC:mah, PMID:17318224, PMID:18498251, PMID:8970738, PMID:9234965]"}
{"concept_id": "C3156644", "aliases": ["xanthosine ribohydrolase activity"], "types": ["T044"], "canonical_name": "xanthosine nucleotidase activity", "definition": "Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine. [GOC:kad, MetaCyc:RXN0-363, PMID:21235647]"}
{"concept_id": "C3156645", "aliases": [], "types": ["T044"], "canonical_name": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity", "definition": "Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. [GOC:mah]"}
{"concept_id": "C3156646", "aliases": [], "types": ["T044"], "canonical_name": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity", "definition": "Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. [GOC:mah]"}
{"concept_id": "C3156647", "aliases": ["box H/ACA RNP complex location"], "types": ["T026"], "canonical_name": "box H/ACA RNP complex", "definition": "A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex. [GOC:BHF, GOC:BHF_telomerase, GOC:jbu, GOC:krc, GOC:mah, GOC:vw, PMID:17284456, PMID:20227365]"}
{"concept_id": "C3156649", "aliases": ["sRNP complex location"], "types": ["T026"], "canonical_name": "sRNP complex"}
{"concept_id": "C3156650", "aliases": ["nucleoplasmic box H/ACA RNP pseudouridylase complex", "box H/ACA scaRNP complex location", "nucleoplasmic box H/ACA RNP pseudouridylase complex location"], "types": ["T026"], "canonical_name": "box H/ACA scaRNP complex", "definition": "A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs. [GOC:mah, PMID:17284456, PMID:20227365]"}
{"concept_id": "C3156651", "aliases": [], "types": ["T044"], "canonical_name": "N-acetyl-L-aspartate-L-glutamate ligase activity", "definition": "Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate. [PMID:20643647, PMID:20657015]"}
{"concept_id": "C3156652", "aliases": [], "types": ["T044"], "canonical_name": "citrate-L-glutamate ligase activity", "definition": "Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate. [PMID:20657015]"}
{"concept_id": "C3156653", "aliases": ["oxygen metabolism", "diatomic oxygen metabolic process"], "types": ["T043"], "canonical_name": "oxygen metabolic process", "definition": "The chemical reactions and pathways involving diatomic oxygen (O2). [GOC:mah]"}
{"concept_id": "C3156654", "aliases": ["ROS metabolic process", "reactive oxygen species metabolism"], "types": ["T043"], "canonical_name": "reactive oxygen species metabolic process", "definition": "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. [GOC:mah]"}
{"concept_id": "C3156655", "aliases": ["establishment of protein localisation to organelle"], "types": ["T043"], "canonical_name": "establishment of protein localization to organelle", "definition": "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. [GOC:mah]"}
{"concept_id": "C3156656", "aliases": ["maintenance of protein localisation to organelle", "maintenance of protein localization to organelle"], "types": ["T038"], "canonical_name": "maintenance of protein localization in organelle", "definition": "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. [GOC:mah]"}
{"concept_id": "C3156657", "aliases": ["establishment of protein localisation to chloroplast"], "types": ["T043"], "canonical_name": "establishment of protein localization to chloroplast", "definition": "The directed movement of a protein to a specific location in a chloroplast. [GOC:mah]"}
{"concept_id": "C3156658", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein location in chloroplast", "definition": "Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere. [GOC:mah]"}
{"concept_id": "C3156659", "aliases": ["protein localisation to chloroplast"], "types": ["T043"], "canonical_name": "protein localization to chloroplast", "definition": "A process in which a protein is transported to, or maintained at, a location in a chloroplast. [GOC:ecd]"}
{"concept_id": "C3156660", "aliases": ["establishment of protein localisation to endoplasmic reticulum", "establishment of protein localization in endoplasmic reticulum", "establishment of protein localisation to ER", "establishment of protein localization to ER"], "types": ["T043"], "canonical_name": "establishment of protein localization to endoplasmic reticulum", "definition": "The directed movement of a protein to a specific location in the endoplasmic reticulum. [GOC:mah]"}
{"concept_id": "C3156696", "aliases": ["IL28A production", "interferon lambda 2 production", "IL-28A production"], "types": ["T040"], "canonical_name": "interleukin-28A production", "definition": "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:15546383]"}
{"concept_id": "C3156698", "aliases": ["IL-28B production", "interferon lambda 3 production", "IL28B production"], "types": ["T040"], "canonical_name": "interleukin-28B production", "definition": "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:15546383]"}
{"concept_id": "C3156700", "aliases": ["IL-29 production", "IL29 production", "interferon lambda 1 production"], "types": ["T040"], "canonical_name": "interleukin-29 production", "definition": "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:15546383]"}
{"concept_id": "C3156702", "aliases": ["IL-30 production", "interleukin-30 complex production"], "types": ["T040"], "canonical_name": "interleukin-30 production", "definition": "The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]"}
{"concept_id": "C3156704", "aliases": ["IL-31 production"], "types": ["T040"], "canonical_name": "interleukin-31 production", "definition": "The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]"}
{"concept_id": "C3156706", "aliases": ["IL32 production", "IL-32 production"], "types": ["T040"], "canonical_name": "interleukin-32 production", "definition": "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:23729669]"}
{"concept_id": "C3156707", "aliases": [], "types": ["T040"], "canonical_name": "NK4 production"}
{"concept_id": "C3156708", "aliases": [], "types": ["T040"], "canonical_name": "TAIF production"}
{"concept_id": "C3156712", "aliases": ["IL-33 production", "IL33 production", "NF-HEV production"], "types": ["T040"], "canonical_name": "interleukin-33 production", "definition": "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:29778524]"}
{"concept_id": "C3156713", "aliases": [], "types": ["T040"], "canonical_name": "C9orf26 production"}
{"concept_id": "C3156714", "aliases": [], "types": ["T040"], "canonical_name": "IL1F11 production"}
{"concept_id": "C3156722", "aliases": ["IFND production", "IFN-delta production"], "types": ["T040"], "canonical_name": "interferon-delta production", "definition": "The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:15546383]"}
{"concept_id": "C3156724", "aliases": ["IFNE production", "IFN-epsilon production"], "types": ["T040"], "canonical_name": "interferon-epsilon production", "definition": "The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:15546383]"}
{"concept_id": "C3156726", "aliases": ["IFNK production", "IFN-kappa production"], "types": ["T040"], "canonical_name": "interferon-kappa production", "definition": "The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:15546383]"}
{"concept_id": "C3156728", "aliases": ["IFN-tau secretion", "IFNT production", "IFN-tau production"], "types": ["T040"], "canonical_name": "interferon-tau production", "definition": "The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:15546383]"}
{"concept_id": "C3156730", "aliases": ["IFNW production", "IFN-omega production"], "types": ["T040"], "canonical_name": "interferon-omega production", "definition": "The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah, PMID:15546383]"}
{"concept_id": "C3156732", "aliases": ["establishment of protein localization in mitochondrion", "establishment of protein localisation to mitochondrion"], "types": ["T043"], "canonical_name": "establishment of protein localization to mitochondrion", "definition": "The directed movement of a protein to the mitochondrion or a part of the mitochondrion. [GOC:mah]"}
{"concept_id": "C3156733", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of protein location in mitochondrion", "definition": "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere. [GOC:mah]"}
{"concept_id": "C3156734", "aliases": ["protein localization in membrane", "protein localisation in membrane"], "types": ["T043"], "canonical_name": "protein localization to membrane", "definition": "A process in which a protein is transported to, or maintained in, a specific location in a membrane. [GOC:mah]"}
{"concept_id": "C3156735", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein location in membrane", "definition": "Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere. [GOC:mah]"}
{"concept_id": "C3156736", "aliases": ["protein localisation in plasma membrane", "protein localization in plasma membrane"], "types": ["T043"], "canonical_name": "protein localization to plasma membrane", "definition": "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah]"}
{"concept_id": "C3156737", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein location in plasma membrane", "definition": "Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere. [GOC:mah]"}
{"concept_id": "C3156739", "aliases": ["protein localisation to peroxisome"], "types": ["T043"], "canonical_name": "protein localization to peroxisome", "definition": "A process in which a protein is transported to, or maintained at, a location in a peroxisome. [GOC:ecd]"}
{"concept_id": "C3156740", "aliases": ["establishment of protein localisation to peroxisome"], "types": ["T043"], "canonical_name": "establishment of protein localization to peroxisome", "definition": "The directed movement of a protein to a specific location in a peroxisome. [GOC:mah]"}
{"concept_id": "C3156741", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein location in peroxisome", "definition": "Any process in which a protein is maintained in a specific location in a peroxisome, and is prevented from moving elsewhere. [GOC:mah]"}
{"concept_id": "C3156742", "aliases": ["protein localisation to vacuole"], "types": ["T043"], "canonical_name": "protein localization to vacuole", "definition": "A process in which a protein is transported to, or maintained at, a location in a vacuole. [GOC:ecd]"}
{"concept_id": "C3156743", "aliases": ["establishment of protein localisation to vacuole"], "types": ["T043"], "canonical_name": "establishment of protein localization to vacuole", "definition": "The directed movement of a protein to a specific location in a vacuole. [GOC:mah]"}
{"concept_id": "C3156744", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein location in vacuole", "definition": "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere. [GOC:mah]"}
{"concept_id": "C3156746", "aliases": ["tRNA splicing ligase complex", "tRNA-splicing ligase complex location", "tRNA splicing ligase complex location"], "types": ["T026"], "canonical_name": "tRNA-splicing ligase complex", "definition": "A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. [GOC:sp, PMID:21311021]"}
{"concept_id": "C3156747", "aliases": ["mitochondrial tRNA t6A modification"], "types": ["T045"], "canonical_name": "mitochondrial tRNA threonylcarbamoyladenosine modification", "definition": "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in mitochondrial tRNAs that decode ANN codons (where N is any base). [GOC:mcc, PMID:21183954]"}
{"concept_id": "C3156748", "aliases": ["mitochondria-associated protein degradation", "mitochondria-associated ubiquitin-dependent protein catabolic process", "MAD", "mitochondria-associated protein catabolic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions. [GOC:mcc, PMID:21070972, PMID:21109188]", "canonical_name": "mitochondrion-associated protein catabolic process"}
{"concept_id": "C3156749", "aliases": [], "types": ["T043"], "canonical_name": "neutrophil extravasation", "definition": "The migration of a neutrophil from the blood vessels into the surrounding tissue. [CL:0000775, GOC:BHF]"}
{"concept_id": "C3156750", "aliases": [], "types": ["T040"], "canonical_name": "lamellipodium morphogenesis", "definition": "A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3156751", "aliases": ["lamellipodium organization"], "types": ["T043"], "canonical_name": "lamellipodium organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. [GOC:als, PMID:16054028]"}
{"concept_id": "C3156752", "aliases": [], "types": ["T043"], "canonical_name": "multinuclear osteoclast differentiation", "definition": "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000779, GOC:mah, PMID:12713016]"}
{"concept_id": "C3156753", "aliases": [], "types": ["T043"], "canonical_name": "multinuclear osteoclast formation"}
{"concept_id": "C3156754", "aliases": [], "types": ["T043"], "canonical_name": "multinuclear osteoclast morphogenesis"}
{"concept_id": "C3156755", "aliases": [], "types": ["T043"], "canonical_name": "osteoclast fusion", "definition": "The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast. [CL:0000092, CL:0000779, GOC:BHF, GOC:mah, PMID:12713016]"}
{"concept_id": "C3156756", "aliases": [], "types": ["T043"], "canonical_name": "lymphocyte migration", "definition": "The movement of a lymphocyte within or between different tissues and organs of the body. [CL:0000542, GOC:BHF, GOC:mah]"}
{"concept_id": "C3156757", "aliases": [], "types": ["T043"], "canonical_name": "eosinophil migration", "definition": "The movement of an eosinophil within or between different tissues and organs of the body. [CL:0000771, GOC:BHF, GOC:mah]"}
{"concept_id": "C3156758", "aliases": ["T-lymphocyte migration", "T lymphocyte migration", "T-cell migration"], "types": ["T043"], "canonical_name": "T cell migration", "definition": "The movement of a T cell within or between different tissues and organs of the body. [CL:0000084, GOC:BHF, GOC:mah]"}
{"concept_id": "C3156759", "aliases": ["thymic lymphocyte migration"], "types": ["T043"], "canonical_name": "thymocyte migration", "definition": "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development. [CL:0000893, GOC:BHF, GOC:mah]"}
{"concept_id": "C3156760", "aliases": ["immature T-cell migration"], "types": ["T043"], "canonical_name": "immature T cell migration"}
{"concept_id": "C3156761", "aliases": ["immature T-lymphocyte migration"], "types": ["T043"], "canonical_name": "immature T lymphocyte migration"}
{"concept_id": "C3156762", "aliases": ["extracellular matrix-dependent thymic lymphocyte migration"], "types": ["T043"], "canonical_name": "extracellular matrix-dependent thymocyte migration", "definition": "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on extracellular matrix components including fibronectin, collagen and laminin. [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819]"}
{"concept_id": "C3156763", "aliases": ["extracellular matrix-dependent immature T-cell migration"], "types": ["T043"], "canonical_name": "extracellular matrix-dependent immature T cell migration"}
{"concept_id": "C3156764", "aliases": ["extracellular matrix-dependent immature T-lymphocyte migration"], "types": ["T043"], "canonical_name": "extracellular matrix-dependent immature T lymphocyte migration"}
{"concept_id": "C3156765", "aliases": ["fibronectin-dependent thymic lymphocyte migration"], "types": ["T043"], "canonical_name": "fibronectin-dependent thymocyte migration", "definition": "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix. [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819]"}
{"concept_id": "C3156766", "aliases": ["fibronectin-dependent immature T-cell migration"], "types": ["T043"], "canonical_name": "fibronectin-dependent immature T cell migration"}
{"concept_id": "C3156767", "aliases": ["fibronectin-dependent immature T-lymphocyte migration"], "types": ["T043"], "canonical_name": "fibronectin-dependent immature T lymphocyte migration"}
{"concept_id": "C3156768", "aliases": [], "types": ["T043"], "canonical_name": "eosinophil extravasation", "definition": "The migration of an eosinophil from the blood vessels into the surrounding tissue. [CL:0000771, GOC:BHF, GOC:mah]"}
{"concept_id": "C3156769", "aliases": ["T lymphocyte extravasation", "T-cell extravasation", "T-lymphocyte extravasation"], "types": ["T043"], "canonical_name": "T cell extravasation", "definition": "The migration of a T cell from the blood vessels into the surrounding tissue. [CL:0000084, GOC:BHF, GOC:mah]"}
{"concept_id": "C3156770", "aliases": ["mitochondrial endonucleolytic tRNA 3'-end cleavage", "mitochondrial tRNA 3'-end cleavage, endonucleolytic", "mitochondrial endonucleolytic tRNA 3'-trailer cleavage"], "types": ["T045"], "canonical_name": "mitochondrial tRNA 3'-trailer cleavage, endonucleolytic", "definition": "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion. [GOC:mah]"}
{"concept_id": "C3156772", "aliases": ["MRN complex assembly", "RAD50-MRE11-NBN complex assembly", "RMX complex assembly", "Rad50-Rad32-Nbs1 complex assembly", "MRX complex assembly", "Rad50 complex assembly"], "types": ["T044"], "canonical_name": "Mre11 complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an Mre11 complex, a trimeric protein complex that possesses endonuclease activity and is involved in meiotic recombination, DNA repair and checkpoint signaling. [GOC:mah, PMID:19211838]"}
{"concept_id": "C3156775", "aliases": [], "types": ["T043"], "canonical_name": "autophagy of host cells involved in interaction with symbiont"}
{"concept_id": "C3156780", "aliases": [], "types": ["T043"], "canonical_name": "autophagy involved in symbiotic interaction"}
{"concept_id": "C3156783", "aliases": ["positive regulation by organism of entry into other organism involved in symbiotic interaction", "up-regulation by organism of entry into other organism during symbiotic interaction", "up regulation by organism of entry into other organism during symbiotic interaction", "upregulation by organism of entry into other organism during symbiotic interaction"], "types": ["T040"], "canonical_name": "positive regulation by organism of entry into other organism during symbiotic interaction"}
{"concept_id": "C3156784", "aliases": ["11-OHJA sulfotransferase activity", "11-hydroxyjasmonic acid sulfotransferase activity", "11-hydroxyjasmonate sulfotransferase activity"], "types": ["T044"], "canonical_name": "11-hydroxyjasmonate sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate. [GOC:pz, RHEA:52732]"}
{"concept_id": "C3156786", "aliases": [], "types": ["T044"], "canonical_name": "borate efflux transmembrane transporter activity", "definition": "Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane. [PMID:18603465]"}
{"concept_id": "C3156787", "aliases": ["positive regulation of salicylic acid mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of salicylic acid mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction. [PMID:20181750]"}
{"concept_id": "C3156788", "aliases": [], "types": ["T044"], "canonical_name": "regulation of reductive pentose-phosphate cycle", "definition": "Any process that modulates the frequency, rate or extent of reductive pentose-phosphate cycle. [PMID:17031544]"}
{"concept_id": "C3156789", "aliases": [], "types": ["T044"], "canonical_name": "regulation of C3 photosynthesis"}
{"concept_id": "C3156790", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Calvin cycle"}
{"concept_id": "C3156791", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of reductive pentose-phosphate cycle", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle. [PMID:17031544, PMID:20399532]"}
{"concept_id": "C3156792", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of C3 photosynthesis"}
{"concept_id": "C3156793", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of Calvin cycle"}
{"concept_id": "C3156794", "aliases": [], "types": ["T038"], "canonical_name": "regulation of fertilization", "definition": "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). [GOC:DHL, PMID:20478994]"}
{"concept_id": "C3156795", "aliases": [], "types": ["T038"], "canonical_name": "regulation of double fertilization forming a zygote and endosperm", "definition": "Any process that modulates the rate, frequency or extent of double fertilization forming a zygote and endosperm. Double fertilization forming a zygote and endosperm is a type of fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana. [GOC:DHL, PMID:20478994]"}
{"concept_id": "C3156796", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial mRNA modification", "definition": "The covalent alteration within the mitochondrion of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically. [PMID:20566637]"}
{"concept_id": "C3156797", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial mRNA editing"}
{"concept_id": "C3156798", "aliases": ["mitochondrial RNA editing"], "types": ["T045"], "canonical_name": "mitochondrial RNA editing"}
{"concept_id": "C3156799", "aliases": ["regulation of plant-type cell wall organisation or biogenesis"], "types": ["T043"], "canonical_name": "regulation of plant-type cell wall organization or biogenesis", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving plant-type cell wall organization or biogenesis. Plant-type cell wall organization or biogenesis is a process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall. [PMID:20530756]"}
{"concept_id": "C3156801", "aliases": [], "types": ["T043"], "canonical_name": "zygote elongation", "definition": "The process in which the zygote irreversibly increases in size in one dimension after fertilization. An example of such a process is found in Arabidopsis thaliana. [GOC:tb]"}
{"concept_id": "C3156802", "aliases": [], "types": ["T043"], "canonical_name": "selenate transport", "definition": "The directed movement of selenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [PMID:18761637]"}
{"concept_id": "C3156803", "aliases": [], "types": ["T044"], "canonical_name": "auxin transmembrane transporter activity", "definition": "Enables the transfer of auxins from one side of a membrane to the other. Auxins are plant hormones that regulate aspects of plant growth. [PMID:19506555]"}
{"concept_id": "C3156804", "aliases": [], "types": ["T043"], "canonical_name": "intracellular auxin transport"}
{"concept_id": "C3156805", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein serine/threonine phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. [PMID:19407142]"}
{"concept_id": "C3156806", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein phosphatase type 2c activity"}
{"concept_id": "C3156807", "aliases": [], "types": ["T044"], "canonical_name": "regulation of nitric oxide metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. [GOC:DHL]"}
{"concept_id": "C3156808", "aliases": [], "types": ["T038"], "canonical_name": "callose deposition in phloem sieve plate", "definition": "Any process in which callose is transported to, and/or maintained in, phloem sieve plate. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. [PMID:19470642]"}
{"concept_id": "C3156809", "aliases": [], "types": ["T042"], "canonical_name": "stomium development", "definition": "The process whose specific outcome is the progression of the stomium over time, from its formation to the mature structure. A stomium is a fissure or pore in the anther lobe through which the pollen is released. [GOC:tb]"}
{"concept_id": "C3156810", "aliases": [], "types": ["T040"], "canonical_name": "response to karrikin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants). [PMID:20351290]"}
{"concept_id": "C3156811", "aliases": [], "types": ["T043"], "canonical_name": "abscisic acid transport", "definition": "The directed movement of abscisic acid into, out of, within or between cells by means of some external agent such as a transporter or pore. [PMID:20133881]"}
{"concept_id": "C3156812", "aliases": ["cellular response to boron deprivation", "cellular response to boron starvation"], "types": ["T043"], "canonical_name": "cellular response to boron-containing substance deprivation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of boron obtained from boron-containing substances. [PMID:20059736]"}
{"concept_id": "C3156813", "aliases": ["hydrogen peroxide membrane transport"], "types": ["T044"], "canonical_name": "hydrogen peroxide transmembrane transport", "definition": "The process in which hydrogen peroxide is transported across a membrane. [GOC:tb]"}
{"concept_id": "C3156814", "aliases": ["lytic vacuole organisation"], "types": ["T043"], "canonical_name": "lytic vacuole organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. [PMID:20729380]"}
{"concept_id": "C3156815", "aliases": ["lytic vacuole biogenesis"], "types": ["T043"], "canonical_name": "lytic vacuolar assembly"}
{"concept_id": "C3156816", "aliases": [], "types": ["T043"], "canonical_name": "lytic vacuole organization and biogenesis"}
{"concept_id": "C3156817", "aliases": [], "types": ["T042"], "canonical_name": "petal epidermis patterning", "definition": "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the cells in the petal epidermis. [GOC:tb]"}
{"concept_id": "C3156818", "aliases": ["male-female gamete recognition"], "types": ["T043"], "canonical_name": "male-female gamete recognition during double fertilization forming a zygote and endosperm", "definition": "The initial contact step made between the male gamete and the female gamete during double fertilization forming a zygote and endosperm. An example can be found in Arabidopsis thaliana. [PMID:21123745]"}
{"concept_id": "C3156819", "aliases": [], "types": ["T043"], "canonical_name": "gamete recognition"}
{"concept_id": "C3156821", "aliases": ["phragmoplast microtubule organisation", "phragmoplast microtubule cytoskeleton organization"], "types": ["T043"], "canonical_name": "phragmoplast microtubule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in phragmoplast, a plant cell specific structure that forms during late cytokinesis. Phragmoplast serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells. [PMID:19383896]"}
{"concept_id": "C3156822", "aliases": [], "types": ["T044"], "canonical_name": "xyloglucan 1,6-alpha-xylosidase activity", "definition": "Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus. [PMID:20801759]"}
{"concept_id": "C3156823", "aliases": ["plastoglobule organisation"], "types": ["T043"], "canonical_name": "plastoglobule organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids. [PMID:20813909]"}
{"concept_id": "C3156824", "aliases": [], "types": ["T044"], "canonical_name": "5-carbamoylmethyluridine metabolic process"}
{"concept_id": "C3156825", "aliases": [], "types": ["T044"], "canonical_name": "1-methylguanosine metabolic process", "definition": "The chemical reactions and pathways involving 1-methylguanosine. [GOC:tb]"}
{"concept_id": "C3156826", "aliases": [], "types": ["T044"], "canonical_name": "2-methylguanosine metabolic process", "definition": "The chemical reactions and pathways involving 2-methylguanosine. [GOC:tb]"}
{"concept_id": "C3156828", "aliases": [], "types": ["T042"], "canonical_name": "dormancy entry of symbiont in host", "definition": "Entry into a dormant state of the symbiont within the host organism. [GOC:jl]"}
{"concept_id": "C3156829", "aliases": ["dormancy maintenance of symbiont in host", "NRP"], "types": ["T042"], "definition": "Any process in which a dormant state is maintained by the symbiont within the host organism. [GOC:jl]", "canonical_name": "non-replicating persistence"}
{"concept_id": "C3156830", "aliases": ["resuscitation of symbiont"], "types": ["T042"], "canonical_name": "dormancy exit of symbiont in host", "definition": "Exit from dormant state, also known as resuscitation, of the symbiont within the host organism. [GOC:jl]"}
{"concept_id": "C3156831", "aliases": ["symbiont entry into host cell forming a pathogen-containing vacuole", "symbiont entry into host cell forming a parasitophorous vacuole", "symbiont entry into host cell forming a symbiont-containing vacuole"], "types": ["T046"], "canonical_name": "entry into host cell by a symbiont-containing vacuole", "definition": "The invasion by a symbiont of a cell of a host organism, forming a vacuole in which the symbiont resides. The vacuole membrane is formed from lipids and proteins derived from both host and symbiont. Begins when the symbiont attaches on to the host cell membrane which invaginates and deepens as the symbiont enters, and ends when the host cell membrane closes behind the newly-formed vacuole. [GOC:jl, PMID:18665841, PMID:8690024, PMID:9580555]"}
{"concept_id": "C3156833", "aliases": ["formation of a symbiont- induced tubovesicular network for nutrient acquisition from host", "formation by symbiont of a tubovesicular network for nutrient acquisition from host"], "types": ["T043"], "canonical_name": "formation of tubovesicular network for nutrient acquisition", "definition": "The assembly of a symbiont-induced complex organelle that comprises of multiple protein and lipid domains for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C3156834", "aliases": ["protein K6-linked polyubiquitination"], "types": ["T044"], "canonical_name": "protein K6-linked ubiquitination", "definition": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair. [GOC:sp]"}
{"concept_id": "C3156840", "aliases": ["TVN", "TVM network"], "types": ["T026"], "canonical_name": "tubovesicular membrane network", "definition": "A complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains. [GOC:pamgo_curators]"}
{"concept_id": "C3156841", "aliases": [], "types": ["T040"], "canonical_name": "entry into host via enzymatic degradation of host anatomical structure"}
{"concept_id": "C3156842", "aliases": [], "types": ["T040"], "canonical_name": "entry into host via enzymatic degradation of host cuticle"}
{"concept_id": "C3156843", "aliases": [], "types": ["T043"], "canonical_name": "extracellular matrix assembly", "definition": "The aggregation, arrangement and bonding together of the extracellular matrix. [GOC:jl]"}
{"concept_id": "C3156844", "aliases": ["modulation by symbiont of host NF-kappaB-mediated signal transduction pathway"], "types": ["T044"], "canonical_name": "modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade", "definition": "Any process in which an organism modulates the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C3156845", "aliases": ["activation by symbiont of host I-kappaB kinase/NF-kappaB cascade", "positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway", "positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade", "stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade", "positive regulation by symbiont of nuclear factor kappa-light-chain-enhancer of activated B cells mediated signal transduction pathway", "up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade", "up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade", "upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade"], "types": ["T044"], "canonical_name": "induction by symbiont of host I-kappaB kinase/NF-kappaB cascade", "definition": "Any process that activates or increases the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C3156846", "aliases": ["negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade"], "types": ["T044"], "canonical_name": "suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C3156847", "aliases": [], "types": ["T026"], "canonical_name": "haustorium", "definition": "A projection from a cell or tissue that penetrates the host's cell wall and invaginates the host cell membrane. [GOC:pamgo_curators]"}
{"concept_id": "C3156848", "aliases": [], "types": ["T026"], "canonical_name": "extrahaustorial matrix", "definition": "The space between the symbiont plasma membrane and the extrahaustorial membrane of the host. [GOC:pamgo_curators]"}
{"concept_id": "C3156849", "aliases": [], "types": ["T026"], "canonical_name": "extrahaustorial membrane", "definition": "The membrane surrounding the symbiont haustorium during symbiosis, derived from the host plasma membrane. [GOC:pamgo_curators]"}
{"concept_id": "C3156850", "aliases": [], "types": ["T026"], "canonical_name": "extra-invasive hyphal membrane"}
{"concept_id": "C3156852", "aliases": [], "types": ["T026"], "canonical_name": "arbuscule", "definition": "Highly branched symbiont haustoria within host root cortex cells, responsible for nutrient exchange. [GOC:pamgo_curators]"}
{"concept_id": "C3156853", "aliases": [], "types": ["T026"], "canonical_name": "periarbuscular membrane", "definition": "A host-derived membrane surrounding the symbiont arbuscule during symbiosis. [GOC:pamgo_curators]"}
{"concept_id": "C3156854", "aliases": ["catabolism of host cuticle"], "types": ["T040"], "canonical_name": "disassembly by symbiont of host cuticle", "definition": "The process in which a symbiont organism effects a breakdown of the host organism cuticle. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:jl, GOC:pamgo_curators]"}
{"concept_id": "C3156855", "aliases": [], "types": ["T040"], "canonical_name": "degradation of host cuticle"}
{"concept_id": "C3156857", "aliases": [], "types": ["T043"], "canonical_name": "receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"}
{"concept_id": "C3156871", "aliases": [], "types": ["T044"], "canonical_name": "G-protein coupled receptor activity, unknown ligand"}
{"concept_id": "C3156872", "aliases": ["orphan G protein coupled receptor activity"], "types": ["T044"], "canonical_name": "orphan G-protein coupled receptor activity"}
{"concept_id": "C3156873", "aliases": [], "types": ["T044"], "canonical_name": "orphan GPCR activity"}
{"concept_id": "C3156874", "aliases": [], "types": ["T044"], "canonical_name": "P2X receptor"}
{"concept_id": "C3156876", "aliases": ["LH receptor", "LHR", "lutropin receptor"], "types": ["T044"], "definition": "Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity. [ISBN:0198506732, PMID:18848524, PMID:1922095]", "canonical_name": "luteinizing hormone receptor activity"}
{"concept_id": "C3156878", "aliases": ["melanophore-stimulating hormone receptor activity", "melanocyte stimulating hormone receptor activity"], "types": ["T044"], "canonical_name": "melanocyte-stimulating hormone receptor activity", "definition": "Combining with melanocyte-stimulating hormone to initiate a change in cell activity. [GOC:jl, PMID:7581459]"}
{"concept_id": "C3156883", "aliases": [], "types": ["T044"], "canonical_name": "apoptosis-activating receptor activity"}
{"concept_id": "C3156886", "aliases": [], "types": ["T044"], "canonical_name": "1-phosphatidylinositol binding", "definition": "Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]"}
{"concept_id": "C3156890", "aliases": [], "types": ["T045"], "canonical_name": "DNA unwinding involved in DNA replication", "definition": "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. [ISBN:071673706X, ISBN:0815316194]"}
{"concept_id": "C3156892", "aliases": [], "types": ["T045"], "canonical_name": "DNA strand elongation during DNA replication"}
{"concept_id": "C3156893", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA replication"}
{"concept_id": "C3156894", "aliases": [], "types": ["T045"], "canonical_name": "meiotic DNA synthesis"}
{"concept_id": "C3156895", "aliases": [], "types": ["T045"], "canonical_name": "premeiotic DNA synthesis"}
{"concept_id": "C3156896", "aliases": ["transcription initiation, DNA-dependent", "DNA-dependent transcription, initiation", "initiation of transcription, DNA-dependent", "initiation of DNA-dependent transcription", "DNA-dependent RNA polymerase complex assembly at promoter"], "types": ["T045"], "canonical_name": "DNA-templated transcription, initiation", "definition": "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. [GOC:jid, GOC:txnOH, PMID:18280161]"}
{"concept_id": "C3156897", "aliases": ["termination of transcription, DNA-dependent", "transcription termination, DNA-dependent", "DNA-dependent transcription, termination", "termination of DNA-dependent transcription"], "types": ["T045"], "canonical_name": "DNA-templated transcription, termination", "definition": "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161]"}
{"concept_id": "C3156898", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional complex disassembly"}
{"concept_id": "C3156899", "aliases": ["DNA-dependent transcription, elongation", "transcription elongation, DNA-dependent", "transcriptional elongation, DNA-dependent"], "types": ["T045"], "canonical_name": "DNA-templated transcription, elongation", "definition": "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]"}
{"concept_id": "C3156902", "aliases": [], "types": ["T043"], "canonical_name": "oligosaccharide-lipid intermediate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. [GOC:dph, GOC:hjd, GOC:isa_complete, GOC:pr, GOC:rb]"}
{"concept_id": "C3156904", "aliases": [], "types": ["T044"], "canonical_name": "vacuolar protein maturation"}
{"concept_id": "C3156905", "aliases": [], "types": ["T044"], "canonical_name": "vacuolar proteolysis"}
{"concept_id": "C3156906", "aliases": [], "types": ["T044"], "canonical_name": "protein processing involved in protein targeting to mitochondrion", "definition": "The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments. [GOC:mcc, PMID:12191769]"}
{"concept_id": "C3156907", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial protein processing during import"}
{"concept_id": "C3156908", "aliases": ["1,2-diacyl-sn-glycero-3-phosphocholine metabolism"], "types": ["T044"], "canonical_name": "1,2-diacyl-sn-glycero-3-phosphocholine metabolic process", "definition": "The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin. [ISBN:0198506732]"}
{"concept_id": "C3156909", "aliases": [], "types": ["T044"], "canonical_name": "lecithin metabolic process"}
{"concept_id": "C3156914", "aliases": ["drug membrane transport", "drug transmembrane transport"], "types": ["T044"], "canonical_name": "xenobiotic transmembrane transport", "definition": "The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:ai, GOC:bf, GOC:krc]"}
{"concept_id": "C3156915", "aliases": ["purine base transmembrane transport", "purine base transport"], "types": ["T043"], "canonical_name": "purine nucleobase transport", "definition": "The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732]"}
{"concept_id": "C3156916", "aliases": [], "types": ["T043"], "canonical_name": "purine transmembrane transport"}
{"concept_id": "C3156917", "aliases": [], "types": ["T043"], "canonical_name": "vesicle docking involved in exocytosis", "definition": "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]"}
{"concept_id": "C3156923", "aliases": [], "types": ["T044"], "canonical_name": "actin ubiquitination", "definition": "The modification of actin by addition of ubiquitin groups. [GOC:mah]"}
{"concept_id": "C3156925", "aliases": [], "types": ["T043"], "canonical_name": "spindle assembly involved in male meiosis II", "definition": "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster. [GOC:mah]"}
{"concept_id": "C3156930", "aliases": [], "types": ["T044"], "canonical_name": "nucleic acid metabolic process", "definition": "Any cellular metabolic process involving nucleic acids. [GOC:dph, GOC:tb]"}
{"concept_id": "C3156931", "aliases": ["nucleic acid phosphodiester bond hydrolysis"], "types": ["T044"], "definition": "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. [GOC:dph, GOC:tb]", "canonical_name": "nucleic acid cleavage"}
{"concept_id": "C3156932", "aliases": [], "types": ["T045"], "canonical_name": "regulation of methylation-dependent chromatin silencing"}
{"concept_id": "C3156933", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of methylation-dependent chromatin silencing"}
{"concept_id": "C3156934", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of methylation-dependent chromatin silencing"}
{"concept_id": "C3156935", "aliases": ["regulation of protein amino acid deacetylation"], "types": ["T044"], "canonical_name": "regulation of protein deacetylation", "definition": "Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:tb]"}
{"concept_id": "C3156936", "aliases": ["positive regulation of protein amino acid deacetylation"], "types": ["T044"], "canonical_name": "positive regulation of protein deacetylation", "definition": "Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ecd, PMID:20027304]"}
{"concept_id": "C3156937", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein targeting to membrane", "definition": "Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:tb]"}
{"concept_id": "C3156938", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein targeting to membrane", "definition": "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:tb]"}
{"concept_id": "C3156939", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of protein targeting to membrane", "definition": "Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:tb]"}
{"concept_id": "C3156940", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of intracellular protein transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. [GOC:tb]"}
{"concept_id": "C3156941", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of intracellular protein transport", "definition": "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. [GOC:tb]"}
{"concept_id": "C3156942", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chylomicron remodeling", "definition": "Any process that modulates the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid. [GOC:tb]"}
{"concept_id": "C3156943", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of chylomicron remodeling", "definition": "Any process that increases the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid. [GOC:BHF]"}
{"concept_id": "C3156944", "aliases": [], "types": ["T040"], "canonical_name": "regulation of chylomicron remnant clearance", "definition": "Any process that modulates the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded. [GOC:tb]"}
{"concept_id": "C3156945", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of chylomicron remnant clearance", "definition": "Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded. [GOC:BHF]"}
{"concept_id": "C3156946", "aliases": ["regulation of superoxide metabolism"], "types": ["T040"], "canonical_name": "regulation of superoxide metabolic process", "definition": "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. [GOC:tb]"}
{"concept_id": "C3156947", "aliases": [], "types": ["T038"], "canonical_name": "prostaglandin secretion involved in immune response", "definition": "The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring. [GOC:dph, GOC:tb]"}
{"concept_id": "C3156948", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of oxidative phosphorylation", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. [GOC:BHF]"}
{"concept_id": "C3156949", "aliases": [], "types": ["T040"], "canonical_name": "regulation of locomotion involved in locomotory behavior", "definition": "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C3156950", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of locomotion involved in locomotory behavior", "definition": "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C3156951", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of locomotion involved in locomotory behavior", "definition": "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. [GOC:dph, GOC:kmv, GOC:tb]"}
{"concept_id": "C3156952", "aliases": [], "types": ["T040"], "canonical_name": "regulation of olfactory learning", "definition": "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. [GOC:dph, GOC:tb]"}
{"concept_id": "C3156953", "aliases": ["regulation of DNA-dependent DNA replication"], "types": ["T045"], "canonical_name": "regulation of DNA-templated DNA replication", "definition": "Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized. [GOC:dph, GOC:tb]"}
{"concept_id": "C3156954", "aliases": [], "types": ["T043"], "canonical_name": "regulation of platelet aggregation", "definition": "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:dph, GOC:tb]"}
{"concept_id": "C3156955", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of platelet aggregation", "definition": "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF]"}
{"concept_id": "C3156956", "aliases": [], "types": ["T039"], "canonical_name": "stomatal closure", "definition": "The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. [GOC:tb]"}
{"concept_id": "C3156957", "aliases": [], "types": ["T039"], "canonical_name": "regulation of stomatal closure", "definition": "Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. [GOC:tb]"}
{"concept_id": "C3156959", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cell wall 1,3-beta-glucan biosynthetic process"}
{"concept_id": "C3156960", "aliases": [], "types": ["T043"], "canonical_name": "regulation of brown fat cell differentiation", "definition": "Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [GOC:tb]"}
{"concept_id": "C3156961", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of brown fat cell differentiation", "definition": "Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [GOC:BHF]"}
{"concept_id": "C3156962", "aliases": [], "types": ["T043"], "canonical_name": "regulation of formin-nucleated actin cable assembly", "definition": "Any process that modulates the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184]"}
{"concept_id": "C3156963", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of formin-nucleated actin cable assembly", "definition": "Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184]"}
{"concept_id": "C3156964", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of formin-nucleated actin cable assembly", "definition": "Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184]"}
{"concept_id": "C3156965", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of secretion of lysosomal enzymes", "definition": "Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell. [GOC:BHF]"}
{"concept_id": "C3156966", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of secretion of lysosomal enzymes", "definition": "Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell. [GOC:BHF]"}
{"concept_id": "C3156969", "aliases": [], "types": ["T043"], "canonical_name": "cellular organohalogen metabolic process", "definition": "The chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells. [GOC:BHF]"}
{"concept_id": "C3156970", "aliases": [], "types": ["T043"], "canonical_name": "cellular organofluorine metabolic process", "definition": "The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells. [GOC:BHF]"}
{"concept_id": "C3156971", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cellular organohalogen metabolic process", "definition": "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells. [GOC:BHF]"}
{"concept_id": "C3156972", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cellular organofluorine metabolic process", "definition": "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells. [GOC:BHF]"}
{"concept_id": "C3156973", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cellular organohalogen metabolic process", "definition": "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells. [GOC:BHF]"}
{"concept_id": "C3156974", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cellular organofluorine metabolic process", "definition": "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells. [GOC:BHF]"}
{"concept_id": "C3156975", "aliases": [], "types": ["T040"], "canonical_name": "seedling development", "definition": "The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge. [GOC:tb, PO:0007131]"}
{"concept_id": "C3156976", "aliases": [], "types": ["T044"], "canonical_name": "regulation of nitrate assimilation", "definition": "Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances. [GOC:tb]"}
{"concept_id": "C3156977", "aliases": [], "types": ["T044"], "canonical_name": "polygalacturonase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of polygalacturonase. [GOC:tb]"}
{"concept_id": "C3156978", "aliases": ["regulation of auxin metabolism"], "types": ["T040"], "canonical_name": "regulation of auxin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth. [GOC:tb]"}
{"concept_id": "C3156979", "aliases": ["positive regulation of auxin metabolism"], "types": ["T044"], "canonical_name": "positive regulation of auxin metabolic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth. [GOC:tb]"}
{"concept_id": "C3156980", "aliases": ["negative regulation of auxin metabolism"], "types": ["T044"], "canonical_name": "negative regulation of auxin metabolic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth. [GOC:tb]"}
{"concept_id": "C3156981", "aliases": ["regulation of tryptophan metabolism"], "types": ["T044"], "canonical_name": "regulation of tryptophan metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [GOC:tb]"}
{"concept_id": "C3156982", "aliases": ["positive regulation of tryptophan metabolism"], "types": ["T043"], "canonical_name": "positive regulation of tryptophan metabolic process", "definition": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [GOC:tb]"}
{"concept_id": "C3156983", "aliases": ["negative regulation of abscisic acid biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of abscisic acid biosynthetic process", "definition": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. [GOC:tb]"}
{"concept_id": "C3156984", "aliases": [], "types": ["T040"], "canonical_name": "platelet-derived growth factor production", "definition": "The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]"}
{"concept_id": "C3156985", "aliases": [], "types": ["T040"], "canonical_name": "regulation of platelet-derived growth factor production", "definition": "Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]"}
{"concept_id": "C3156986", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of platelet-derived growth factor production", "definition": "Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]"}
{"concept_id": "C3156987", "aliases": [], "types": ["T040"], "canonical_name": "regulation of proteasome core complex assembly", "definition": "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles. [GOC:dph, GOC:elh, GOC:tb]"}
{"concept_id": "C3156988", "aliases": [], "types": ["T040"], "canonical_name": "regulation of proteasome assembly", "definition": "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex. [GOC:dph, GOC:elh, GOC:tb]"}
{"concept_id": "C3156989", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA modification", "definition": "Any process that modulates the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. [GOC:dph, GOC:sl, GOC:tb, PMID:14559896]"}
{"concept_id": "C3156990", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA editing"}
{"concept_id": "C3156991", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mRNA modification", "definition": "Any process that increases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C3156992", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mRNA modification", "definition": "Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. [GOC:dph, GOC:sl, GOC:tb]"}
{"concept_id": "C3156993", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ornithine metabolic process", "definition": "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. [GOC:dph, GOC:jp, GOC:tb]"}
{"concept_id": "C3156994", "aliases": [], "types": ["T044"], "canonical_name": "ornithine carbamoyltransferase inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase. [GOC:dph, GOC:jp, GOC:tb]"}
{"concept_id": "C3156995", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cholesterol efflux", "definition": "Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:dph, GOC:tb, GOC:yaf]"}
{"concept_id": "C3156996", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glycerol transport", "definition": "Any process that modulates the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:jh, GOC:tb]"}
{"concept_id": "C3156997", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glycerol transport", "definition": "Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:jh, GOC:tb]"}
{"concept_id": "C3156998", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glycerol transport", "definition": "Any process that decreases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:jh, GOC:tb]"}
{"concept_id": "C3156999", "aliases": [], "types": ["T043"], "canonical_name": "oligopeptide export from mitochondrion", "definition": "The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [PMID:11251115]"}
{"concept_id": "C3157000", "aliases": ["negative regulation of transcription from RNA polymerase II promoter in response to iron deficiency"], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation", "definition": "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions. [GOC:tb]"}
{"concept_id": "C3157001", "aliases": ["seed hair differentiation"], "types": ["T043"], "canonical_name": "seed trichome differentiation", "definition": "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function. [GOC:tb, PMID:17905721]"}
{"concept_id": "C3157002", "aliases": [], "types": ["T043"], "canonical_name": "cotton fiber development"}
{"concept_id": "C3157003", "aliases": [], "types": ["T043"], "canonical_name": "seed trichome development"}
{"concept_id": "C3157004", "aliases": ["seed trichome fate commitment"], "types": ["T043"], "canonical_name": "seed trichome initiation", "definition": "The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis. [PMID:17905721]"}
{"concept_id": "C3157005", "aliases": [], "types": ["T043"], "canonical_name": "seed trichome elongation", "definition": "The process in which a seed trichome irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell. [GOC:tb]"}
{"concept_id": "C3157006", "aliases": ["secondary cell wall biosynthesis involved in seed trichome differentiation"], "types": ["T043"], "canonical_name": "secondary cell wall biogenesis involved in seed trichome differentiation", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall of seed trichomes after cell expansion is complete. [GOC:tb]"}
{"concept_id": "C3157007", "aliases": [], "types": ["T043"], "canonical_name": "seed trichome secondary wall biosynthesis"}
{"concept_id": "C3157008", "aliases": [], "types": ["T043"], "canonical_name": "seed trichome maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a seed trichome to attain its fully functional state. [GOC:tb]"}
{"concept_id": "C3157009", "aliases": [], "types": ["T043"], "canonical_name": "regulation of heart induction", "definition": "Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart. [GOC:dph, GOC:tb]"}
{"concept_id": "C3157010", "aliases": [], "types": ["T043"], "canonical_name": "phagosome maturation", "definition": "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3157011", "aliases": ["phagosomal acidification"], "types": ["T043"], "canonical_name": "phagosome acidification", "definition": "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3157012", "aliases": ["lysosome recruitment to phagosome"], "types": ["T043"], "canonical_name": "phagosome-lysosome docking", "definition": "The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3157013", "aliases": [], "types": ["T043"], "canonical_name": "phagosome-lysosome fusion", "definition": "The creation of a phagolysosome from a phagosome and a lysosome. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3157014", "aliases": [], "types": ["T043"], "canonical_name": "phagosome maturation involved in apoptotic cell clearance", "definition": "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3157015", "aliases": [], "types": ["T043"], "canonical_name": "phagolysosome assembly involved in apoptotic cell clearance", "definition": "The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3157016", "aliases": [], "types": ["T043"], "canonical_name": "phagosome-lysosome docking involved in apoptotic cell clearance", "definition": "The initial attachment of a phagosome membrane to a lysosome membrane that occurs as a part of apoptotic cell clearance. Docking requires only that the proteins come close enough to interact and adhere. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3157017", "aliases": [], "types": ["T043"], "canonical_name": "phagosome-lysosome fusion involved in apoptotic cell clearance", "definition": "The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3157018", "aliases": [], "types": ["T043"], "canonical_name": "phagosome acidification involved in apoptotic cell clearance", "definition": "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion, and occurs as a part of apoptotic cell clearance. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3157019", "aliases": ["grana formation"], "types": ["T043"], "canonical_name": "granum assembly", "definition": "A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts. [GOC:tb]"}
{"concept_id": "C3157020", "aliases": [], "types": ["T042"], "canonical_name": "sepal giant cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a sepal giant cell. A sepal giant cell is a pavement cell that is part of the sepal epidermis and stretches one fifth the length of the sepal with a chromosome content of 16C. [GOC:tb, PMID:20485493]"}
{"concept_id": "C3157021", "aliases": [], "types": ["T043"], "canonical_name": "sepal giant cell development", "definition": "The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:tb]"}
{"concept_id": "C3157022", "aliases": [], "types": ["T043"], "canonical_name": "sepal giant cell formation"}
{"concept_id": "C3157023", "aliases": ["negative regulation of excitatory post-synaptic membrane potential", "reduction of excitatory postsynaptic membrane potential"], "types": ["T043"], "canonical_name": "negative regulation of excitatory postsynaptic potential", "definition": "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:BHF]"}
{"concept_id": "C3157024", "aliases": [], "types": ["T026"], "canonical_name": "plant cell papilla", "definition": "A cell projection that is a short, rounded projection from a plant epidermal cell. [GOC:tb]"}
{"concept_id": "C3157025", "aliases": [], "types": ["T026"], "canonical_name": "leaf papilla", "definition": "A plant cell papilla that is part of a leaf papilla cell. [GOC:tb]"}
{"concept_id": "C3157026", "aliases": [], "types": ["T026"], "canonical_name": "stigma papilla", "definition": "A plant cell papilla that is part of a stigma papilla cell. [GOC:tb]"}
{"concept_id": "C3157027", "aliases": ["SIPS"], "types": ["T043"], "definition": "A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays. [GOC:BHF]", "canonical_name": "stress-induced premature senescence"}
{"concept_id": "C3157029", "aliases": [], "types": ["T043"], "canonical_name": "oxidative stress-induced premature senescence", "definition": "A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals. [GOC:BHF]"}
{"concept_id": "C3157030", "aliases": [], "types": ["T026"], "canonical_name": "pollen tube tip", "definition": "The region at growing end of the pollen tube cell, where polarized growth occurs. [GOC:tb, PO:0025195, PO:0025281]"}
{"concept_id": "C3157031", "aliases": [], "types": ["T026"], "canonical_name": "unicellular trichome branch", "definition": "A cell projection part that is a branch of a unicellular trichome. [GOC:tb, PO:0025537]"}
{"concept_id": "C3157032", "aliases": [], "types": ["T038"], "canonical_name": "organophosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. [GOC:chem_mtg]"}
{"concept_id": "C3157033", "aliases": [], "types": ["T043"], "canonical_name": "phloem nitrate loading", "definition": "The process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink. [GOC:tb]"}
{"concept_id": "C3157034", "aliases": [], "types": ["T044"], "canonical_name": "ceramide binding", "definition": "Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes. [GOC:sart]"}
{"concept_id": "C3157035", "aliases": ["inner bounding mitochondrial membrane"], "types": ["T026"], "canonical_name": "mitochondrial inner boundary membrane", "definition": "The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane. [GOC:mcc, PMID:16054341, PMID:19019989]"}
{"concept_id": "C3157036", "aliases": ["AKH receptor activity"], "types": ["T044"], "canonical_name": "adipokinetic hormone receptor activity", "definition": "Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. [GOC:sart, PMID:11904407]"}
{"concept_id": "C3157037", "aliases": ["AKH binding"], "types": ["T044"], "canonical_name": "adipokinetic hormone binding", "definition": "Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. [GOC:sart, PMID:11904407]"}
{"concept_id": "C3157038", "aliases": ["AKH receptor binding"], "types": ["T044"], "canonical_name": "adipokinetic hormone receptor binding", "definition": "Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. [GOC:sart, PMID:11904407]"}
{"concept_id": "C3157039", "aliases": [], "types": ["T038"], "canonical_name": "regulation of plasma lipoprotein particle levels", "definition": "Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. [GOC:BHF]"}
{"concept_id": "C3157040", "aliases": [], "types": ["T038"], "canonical_name": "plasma lipoprotein particle homeostasis"}
{"concept_id": "C3157041", "aliases": ["TMTT synthase activity", "4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity"], "types": ["T044"], "canonical_name": "4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity", "definition": "Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone. [GOC:kad, MetaCyc:RXN-8620, PMID:21088219]"}
{"concept_id": "C3157042", "aliases": ["(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone. [GOC:kad, MetaCyc:RXN-8619, PMID:21088219]", "canonical_name": "(3E)-4,8-dimethylnona-1,3,7-triene synthase activity"}
{"concept_id": "C3157043", "aliases": [], "types": ["T038"], "canonical_name": "energy homeostasis", "definition": "Any process involved in the balance between food intake (energy input) and energy expenditure. [GOC:yaf, PMID:15919751]"}
{"concept_id": "C3157044", "aliases": ["eIF-4F assembly", "eIF4F assembly"], "types": ["T044"], "canonical_name": "eukaryotic translation initiation factor 4F complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex. [GOC:BHF, GOC:ebc, PMID:18337562]"}
{"concept_id": "C3157045", "aliases": ["cellular response to GM-CSF stimulus"], "types": ["T043"], "canonical_name": "cellular response to granulocyte macrophage colony-stimulating factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus. [GOC:BHF, GOC:ebc, PMID:7901744]"}
{"concept_id": "C3157046", "aliases": ["response to granulocyte macrophage colony-stimulating factor stimulus", "response to GM-CSF"], "types": ["T043"], "canonical_name": "response to granulocyte macrophage colony-stimulating factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus. [GOC:pr]"}
{"concept_id": "C3157047", "aliases": [], "types": ["T026"], "canonical_name": "phagocytic vesicle lumen", "definition": "The volume enclosed by the membrane of a phagocytic vesicle. [GOC:rs]"}
{"concept_id": "C3157048", "aliases": ["microtubule-based flagellum cytoplasm", "microtubule-based flagellar cytoplasm", "cilium cytoplasm", "cilial cytoplasm"], "types": ["T026"], "canonical_name": "ciliary cytoplasm"}
{"concept_id": "C3157049", "aliases": [], "types": ["T026"], "canonical_name": "microtubule-based flagellar matrix"}
{"concept_id": "C3157050", "aliases": [], "types": ["T026"], "canonical_name": "microtubule-based flagellum matrix"}
{"concept_id": "C3157052", "aliases": [], "types": ["T044"], "canonical_name": "L27 domain binding", "definition": "Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner. [GOC:BHF, PMID:15241471, PMID:17237226, Prosite:PDOC51022]"}
{"concept_id": "C3157053", "aliases": [], "types": ["T039"], "canonical_name": "renal protein absorption", "definition": "A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). [GOC:yaf, PMID:18431508]"}
{"concept_id": "C3157054", "aliases": [], "types": ["T039"], "canonical_name": "renal albumin absorption", "definition": "A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. [GOC:yaf, PMID:18431508]"}
{"concept_id": "C3157055", "aliases": ["neurotransmitter receptor degradation", "neurotransmitter receptor catabolism", "neurotransmitter receptor breakdown"], "types": ["T044"], "canonical_name": "neurotransmitter receptor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of neurotransmitter receptors. [GOC:kmv]"}
{"concept_id": "C3157056", "aliases": [], "types": ["T044"], "canonical_name": "COPII receptor activity", "definition": "Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles. [GOC:rb, PMID:16957051, PMID:20236934]"}
{"concept_id": "C3157057", "aliases": [], "types": ["T043"], "canonical_name": "lymphocyte migration into lymphoid organs", "definition": "The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen. [GOC:BHF, GOC:pr, PMID:18379575]"}
{"concept_id": "C3157058", "aliases": ["lymphocyte homing"], "types": ["T043"], "canonical_name": "lymphocyte migration into lymph node", "definition": "The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen. [GOC:BHF, GOC:pr, PMID:18379575]"}
{"concept_id": "C3157059", "aliases": [], "types": ["T044"], "canonical_name": "fructose 6-phosphate aldolase activity", "definition": "Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate. [GOC:imk, PMID:11120740, PMID:21290439]"}
{"concept_id": "C3157061", "aliases": ["MPP7-DLG1-LIN7 complex location"], "types": ["T026"], "canonical_name": "MPP7-DLG1-LIN7 complex", "definition": "A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions. [GOC:BHF, PMID:17237226]"}
{"concept_id": "C3157062", "aliases": [], "types": ["T043"], "canonical_name": "dendritic cell dendrite assembly", "definition": "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. [CL:0000451, GOC:BHF, PMID:12200351]"}
{"concept_id": "C3157063", "aliases": [], "types": ["T043"], "canonical_name": "dendritic extension"}
{"concept_id": "C3157064", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin-protein transferase activator activity", "definition": "Binds to and increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. [GOC:rb, PMID:18321851]"}
{"concept_id": "C3157065", "aliases": [], "types": ["T043"], "canonical_name": "dendritic cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. [CL:0000451, GOC:pr]"}
{"concept_id": "C3157066", "aliases": [], "types": ["T043"], "canonical_name": "mature conventional dendritic cell differentiation", "definition": "The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells. [GOC:BHF, http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.aspx, PMID:15845453]"}
{"concept_id": "C3157067", "aliases": ["centromeric nucleosome binding"], "types": ["T045"], "canonical_name": "centromere-specific nucleosome binding"}
{"concept_id": "C3157072", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane lipid distribution", "definition": "Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. [GOC:mah, PMID:18441123, PMID:20823909]"}
{"concept_id": "C3157073", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plasma membrane sterol distribution", "definition": "Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane. [GOC:mah, PMID:18441123, PMID:20823909]"}
{"concept_id": "C3157074", "aliases": [], "types": ["T043"], "canonical_name": "heme export", "definition": "The directed movement of heme out of a cell or organelle. [GOC:lf, PMID:15369674, PMID:20610401]"}
{"concept_id": "C3157075", "aliases": ["perinuclear ER"], "types": ["T026"], "canonical_name": "perinuclear endoplasmic reticulum", "definition": "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]"}
{"concept_id": "C3157076", "aliases": [], "types": ["T044"], "canonical_name": "protein linear polyubiquitination", "definition": "A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein. [GOC:jsg, GOC:sp, PMID:21455173, PMID:21455180, PMID:21455181]"}
{"concept_id": "C3157077", "aliases": [], "types": ["T044"], "canonical_name": "M1 linkage"}
{"concept_id": "C3157078", "aliases": ["phthiocerol synthesis", "phthiocerol anabolism", "phthiocerol formation", "phthiocerol biosynthesis"], "types": ["T044"], "canonical_name": "phthiocerol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents. [GOC:dph, GOC:ecd, PMID:9201977]"}
{"concept_id": "C3157079", "aliases": ["phenolphthiocerol biosynthesis", "phenolic phthiocerol formation", "phenolic phthiocerol anabolism", "phenolic phthiocerol biosynthesis", "phenolic phthiocerol synthesis"], "types": ["T044"], "canonical_name": "phenolic phthiocerol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position. [GOC:dph, GOC:ecd, PMID:9201977]"}
{"concept_id": "C3157080", "aliases": ["extrinsic to fungal-type vacuolar membrane"], "types": ["T026"], "canonical_name": "extrinsic component of fungal-type vacuolar membrane", "definition": "The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:jh, PMID:21454883]"}
{"concept_id": "C3157081", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K56 acetylation", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone. [GOC:bf, GOC:pr]"}
{"concept_id": "C3157082", "aliases": [], "types": ["T043"], "canonical_name": "histone H3-K56 acetylation in response to DNA damage", "definition": "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone as a result of the detection of DNA damage within a cell. [GOC:pr, GOC:vw, PMID:18344406]"}
{"concept_id": "C3157083", "aliases": [], "types": ["T043"], "canonical_name": "phosphatidylserine exposure on blood platelet", "definition": "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system. [GOC:bf, GOC:lf, GOC:pr, PMID:21107324]"}
{"concept_id": "C3157084", "aliases": [], "types": ["T045"], "canonical_name": "replication fork progression beyond termination site", "definition": "Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks. [GOC:bf, GOC:mcc, GOC:pr, PMID:20797631]"}
{"concept_id": "C3157085", "aliases": ["TER"], "types": ["T026"], "definition": "A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks. [GOC:mcc, GOC:pr, PMID:20797631]", "canonical_name": "DNA replication termination region"}
{"concept_id": "C3157086", "aliases": ["dendritic cell apoptosis"], "types": ["T043"], "canonical_name": "dendritic cell apoptotic process", "definition": "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845]"}
{"concept_id": "C3157087", "aliases": ["motor neuron apoptosis", "motoneuron apoptosis"], "types": ["T043"], "canonical_name": "motor neuron apoptotic process", "definition": "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086]"}
{"concept_id": "C3157088", "aliases": ["pancreatic B cell apoptosis", "pancreatic beta cell apoptosis", "type B pancreatic cell apoptosis"], "types": ["T043"], "canonical_name": "type B pancreatic cell apoptotic process", "definition": "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305]"}
{"concept_id": "C3157089", "aliases": ["establishment of protein localisation in endoplasmic reticulum membrane", "establishment of protein localization in endoplasmic reticulum membrane"], "types": ["T043"], "canonical_name": "establishment of protein localization to endoplasmic reticulum membrane", "definition": "The directed movement of a protein to a specific location in the endoplasmic reticulum membrane. [GOC:rb, PMID:9388185]"}
{"concept_id": "C3157090", "aliases": ["L-kynurenine metabolism"], "types": ["T044"], "canonical_name": "L-kynurenine metabolic process", "definition": "The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). [GOC:yaf]"}
{"concept_id": "C3157091", "aliases": ["L-kynurenine degradation", "L-kynurenine breakdown", "L-kynurenine catabolism"], "types": ["T044"], "canonical_name": "L-kynurenine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). [GOC:yaf]"}
{"concept_id": "C3157092", "aliases": ["L-glutamate anabolism", "L-glutamate biosynthesis", "L-glutamate synthesis", "L-glutamate formation"], "types": ["T044"], "canonical_name": "L-glutamate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid. [GOC:yaf]"}
{"concept_id": "C3157093", "aliases": ["agmatine biosynthesis", "agmatine synthesis", "agmatine anabolism", "agmatine formation"], "types": ["T044"], "canonical_name": "agmatine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. [GOC:pr, GOC:yaf]"}
{"concept_id": "C3157094", "aliases": ["selenocysteinyl-tRNA(Sec) anabolism", "selenocysteinyl-tRNA(Sec) formation", "selenocysteinyl-tRNA(Sec) synthesis", "selenocysteinyl-tRNA(Sec) biosynthesis"], "types": ["T045"], "canonical_name": "selenocysteinyl-tRNA(Sec) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine. [GOC:yaf, PMID:15317934, UniPathway:UPA00906]"}
{"concept_id": "C3157095", "aliases": ["TRAF2-GSTP1 complex location"], "types": ["T026"], "canonical_name": "TRAF2-GSTP1 complex", "definition": "A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses. [GOC:BHF, PMID:16636664]"}
{"concept_id": "C3157096", "aliases": ["CRLF-CLCF1 complex location"], "types": ["T026"], "canonical_name": "CRLF-CLCF1 complex", "definition": "A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex. [GOC:BHF, PMID:10966616]"}
{"concept_id": "C3157097", "aliases": ["CLF-CLC complex location"], "types": ["T026"], "canonical_name": "CLF-CLC complex"}
{"concept_id": "C3157098", "aliases": ["CNTFR-CLCF1 complex location"], "types": ["T026"], "canonical_name": "CNTFR-CLCF1 complex", "definition": "A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space. [GOC:BHF, PMID:11285233]"}
{"concept_id": "C3157099", "aliases": ["sCNTFR-CLC complex location"], "types": ["T026"], "canonical_name": "sCNTFR-CLC complex"}
{"concept_id": "C3157100", "aliases": [], "types": ["T043"], "canonical_name": "regulation of DNA damage checkpoint", "definition": "Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. [GOC:obol]"}
{"concept_id": "C3157101", "aliases": [], "types": ["T043"], "canonical_name": "regulation of DNA damage response, signal transduction resulting in cell cycle arrest"}
{"concept_id": "C3157102", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of DNA damage checkpoint", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint. [GOC:BHF, GOC:obol]"}
{"concept_id": "C3157103", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of DNA damage response, signal transduction resulting in cell cycle arrest"}
{"concept_id": "C3157104", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of DNA damage checkpoint", "definition": "Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint. [GOC:obol]"}
{"concept_id": "C3157105", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of DNA damage response, signal transduction resulting in cell cycle arrest"}
{"concept_id": "C3157106", "aliases": [], "types": ["T042"], "canonical_name": "regulation of metanephric S-shaped body morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157107", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of metanephric S-shaped body morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157108", "aliases": [], "types": ["T042"], "canonical_name": "regulation of metanephric comma-shaped body morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157109", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of metanephric comma-shaped body morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157110", "aliases": ["regulation of protein localization at cell surface", "regulation of protein localisation at cell surface"], "types": ["T043"], "canonical_name": "regulation of protein localization to cell surface", "definition": "Any process that modulates the frequency, rate or extent of protein localization to the cell surface. [GOC:obol]"}
{"concept_id": "C3157111", "aliases": ["negative regulation of protein localisation at cell surface", "negative regulation of protein localization at cell surface"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to cell surface", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface. [GOC:obol]"}
{"concept_id": "C3157112", "aliases": ["positive regulation of protein localisation at cell surface", "positive regulation of protein localization at cell surface"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to cell surface", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. [GOC:obol]"}
{"concept_id": "C3157113", "aliases": [], "types": ["T038"], "canonical_name": "regulation of adaxial/abaxial pattern formation", "definition": "Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation. [GOC:obol]"}
{"concept_id": "C3157114", "aliases": [], "types": ["T038"], "canonical_name": "regulation of adaxial/abaxial pattern specification"}
{"concept_id": "C3157115", "aliases": [], "types": ["T043"], "canonical_name": "regulation of auxin polar transport", "definition": "Any process that modulates the frequency, rate or extent of auxin polar transport. [GOC:obol]"}
{"concept_id": "C3157116", "aliases": ["regulation of arginine synthesis via ornithine", "regulation of arginine anabolism via ornithine", "regulation of arginine formation via ornithine"], "types": ["T044"], "canonical_name": "regulation of arginine biosynthetic process via ornithine", "definition": "Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine. [GOC:obol]"}
{"concept_id": "C3157117", "aliases": [], "types": ["T040"], "canonical_name": "regulation of endosperm development", "definition": "Any process that modulates the frequency, rate or extent of endosperm development. [GOC:obol]"}
{"concept_id": "C3157118", "aliases": [], "types": ["T038"], "canonical_name": "regulation of determination of dorsal identity", "definition": "Any process that modulates the frequency, rate or extent of determination of dorsal identity. [GOC:obol]"}
{"concept_id": "C3157119", "aliases": [], "types": ["T038"], "canonical_name": "regulation of determination of adaxial identity"}
{"concept_id": "C3157120", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of determination of dorsal identity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity. [GOC:BHF, GOC:obol]"}
{"concept_id": "C3157121", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of determination of adaxial identity"}
{"concept_id": "C3157122", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of determination of dorsal identity", "definition": "Any process that activates or increases the frequency, rate or extent of determination of dorsal identity. [GOC:obol]"}
{"concept_id": "C3157123", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of determination of adaxial identity"}
{"concept_id": "C3157124", "aliases": ["regulation of testicular development", "regulation of testis development"], "types": ["T038"], "canonical_name": "regulation of male gonad development", "definition": "Any process that modulates the frequency, rate or extent of male gonad development. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157125", "aliases": ["negative regulation of testicular development", "negative regulation of testis development"], "types": ["T038"], "canonical_name": "negative regulation of male gonad development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157126", "aliases": ["positive regulation of testicular development", "positive regulation of testis development"], "types": ["T038"], "canonical_name": "positive regulation of male gonad development", "definition": "Any process that activates or increases the frequency, rate or extent of male gonad development. [GOC:obol]"}
{"concept_id": "C3157131", "aliases": ["regulation of jasmonic acid mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of jasmonic acid mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3157132", "aliases": [], "types": ["T040"], "canonical_name": "regulation of lateral root development", "definition": "Any process that modulates the frequency, rate or extent of lateral root development. [GOC:obol]"}
{"concept_id": "C3157133", "aliases": [], "types": ["T038"], "canonical_name": "regulation of leaf development", "definition": "Any process that modulates the frequency, rate or extent of leaf development. [GOC:obol]"}
{"concept_id": "C3157134", "aliases": [], "types": ["T038"], "canonical_name": "regulation of leaf formation", "definition": "Any process that modulates the frequency, rate or extent of leaf formation. [GOC:obol]"}
{"concept_id": "C3157135", "aliases": [], "types": ["T038"], "canonical_name": "regulation of multicellular organismal development", "definition": "Any process that modulates the frequency, rate or extent of multicellular organismal development. [GOC:obol]"}
{"concept_id": "C3157136", "aliases": [], "types": ["T042"], "canonical_name": "regulation of animal organ morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of animal organ morphogenesis. [GOC:obol]"}
{"concept_id": "C3157137", "aliases": [], "types": ["T042"], "canonical_name": "regulation of histogenesis and organogenesis"}
{"concept_id": "C3157138", "aliases": ["regulation of response to night length, flowering", "regulation of photoperiodic control of flowering time", "regulation of photoperiodic control of inflorescence development", "regulation of response to photoperiod, flowering", "regulation of response to day length, flowering"], "types": ["T040"], "canonical_name": "regulation of photoperiodism, flowering", "definition": "Any process that modulates the frequency, rate or extent of photoperiodism, flowering. [GOC:obol]"}
{"concept_id": "C3157139", "aliases": ["regulation of proanthocyanidin anabolism", "regulation of proanthocyanidin formation", "regulation of proanthocyanidin biosynthesis", "regulation of proanthocyanidin synthesis"], "types": ["T044"], "canonical_name": "regulation of proanthocyanidin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157140", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to red or far red light", "definition": "Any process that modulates the frequency, rate or extent of response to red or far red light. [GOC:obol]"}
{"concept_id": "C3157141", "aliases": ["regulation of salicylic acid mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of salicylic acid mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3157142", "aliases": ["regulation of axillary shoot system formation"], "types": ["T038"], "canonical_name": "regulation of secondary shoot formation", "definition": "Any process that modulates the frequency, rate or extent of secondary shoot formation. [GOC:obol]"}
{"concept_id": "C3157143", "aliases": [], "types": ["T040"], "canonical_name": "regulation of seed dormancy"}
{"concept_id": "C3157144", "aliases": [], "types": ["T040"], "canonical_name": "regulation of seed maturation", "definition": "Any process that modulates the frequency, rate or extent of seed maturation. [GOC:obol]"}
{"concept_id": "C3157145", "aliases": ["regulation of stem cell renewal"], "types": ["T043"], "canonical_name": "regulation of stem cell division", "definition": "Any process that modulates the frequency, rate or extent of stem cell division. [GOC:obol]"}
{"concept_id": "C3157146", "aliases": [], "types": ["T043"], "canonical_name": "regulation of stem cell population maintenance", "definition": "Any process that modulates the frequency, rate or extent of stem cell population maintenance. [GOC:obol]"}
{"concept_id": "C3157147", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maintenance of pluripotency"}
{"concept_id": "C3157148", "aliases": [], "types": ["T038"], "canonical_name": "regulation of stomatal complex patterning", "definition": "Any process that modulates the frequency, rate or extent of stomatal complex patterning. [GOC:obol]"}
{"concept_id": "C3157149", "aliases": [], "types": ["T040"], "canonical_name": "regulation of stomatal complex development", "definition": "Any process that modulates the frequency, rate or extent of stomatal complex development. [GOC:obol]"}
{"concept_id": "C3157150", "aliases": ["regulation of trichome cell morphogenesis during differentiation"], "types": ["T038"], "canonical_name": "regulation of trichome morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of trichome morphogenesis. [GOC:obol]"}
{"concept_id": "C3157151", "aliases": [], "types": ["T038"], "canonical_name": "regulation of planar cell polarity pathway involved in axis elongation", "definition": "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation. [GOC:dph]"}
{"concept_id": "C3157152", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of planar cell polarity pathway involved in axis elongation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation. [GOC:dph]"}
{"concept_id": "C3157153", "aliases": ["negative regulation of homologous recombinational repair", "negative regulation of Rad51-dependent recombinational repair", "negative regulation of HRR", "negative regulation of Rhp51-dependent recombinational repair", "negative regulation of homology-directed repair", "negative regulation of HDR"], "types": ["T043"], "canonical_name": "negative regulation of double-strand break repair via homologous recombination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination. [GOC:vw]"}
{"concept_id": "C3157154", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardiac cell fate specification", "definition": "Any process that modulates the frequency, rate or extent of cardiac cell fate specification. [GOC:BHF]"}
{"concept_id": "C3157155", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cardiac cell fate specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification. [GOC:BHF]"}
{"concept_id": "C3157156", "aliases": [], "types": ["T043"], "canonical_name": "regulation of G1/S transition of mitotic cell cycle", "definition": "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3157158", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell-cell adhesion mediated by cadherin", "definition": "Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. [GOC:obol]"}
{"concept_id": "C3157159", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell-cell adhesion mediated by cadherin", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin. [GOC:obol]"}
{"concept_id": "C3157160", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell-cell adhesion mediated by cadherin", "definition": "Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin. [GOC:obol]"}
{"concept_id": "C3157162", "aliases": ["negative regulation of non-canonical Wnt receptor signalling pathway", "negative regulation of non-canonical Wnt receptor signaling pathway", "negative regulation of non-canonical Wnt-activated signaling pathway", "negative regulation of beta-catenin-independent Wnt receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of non-canonical Wnt signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157164", "aliases": ["regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification", "regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification", "regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification"], "types": ["T044"], "canonical_name": "regulation of Wnt signaling pathway involved in dorsal/ventral axis specification", "definition": "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157165", "aliases": ["negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification", "negative regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification", "negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification"], "types": ["T044"], "canonical_name": "negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157166", "aliases": ["positive regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification", "positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification", "positive regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification"], "types": ["T044"], "canonical_name": "positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification", "definition": "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. [GOC:obol]"}
{"concept_id": "C3157167", "aliases": ["regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis", "regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis"], "types": ["T044"], "canonical_name": "regulation of Wnt signaling pathway involved in digestive tract morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis. [GOC:obol]"}
{"concept_id": "C3157168", "aliases": ["negative regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis", "negative regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis", "negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis"], "types": ["T044"], "canonical_name": "negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis. [GOC:obol]"}
{"concept_id": "C3157169", "aliases": ["regulation of protein ubiquitination during ubiquitin-dependent protein catabolism", "regulation of protein ubiquitination during ubiquitin-dependent protein degradation", "regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process", "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism", "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism", "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process", "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process", "regulation of protein ubiquitination during ubiquitin-dependent protein breakdown"], "types": ["T044"], "canonical_name": "regulation of ubiquitin-dependent protein catabolic process", "definition": "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process. [GOC:BHF]"}
{"concept_id": "C3157170", "aliases": [], "types": ["T044"], "canonical_name": "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown"}
{"concept_id": "C3157171", "aliases": [], "types": ["T044"], "canonical_name": "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process"}
{"concept_id": "C3157172", "aliases": [], "types": ["T044"], "canonical_name": "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism"}
{"concept_id": "C3157173", "aliases": [], "types": ["T044"], "canonical_name": "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation"}
{"concept_id": "C3157174", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein degradation tagging activity"}
{"concept_id": "C3157175", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process"}
{"concept_id": "C3157176", "aliases": ["negative regulation of protein ubiquitination during ubiquitin-dependent protein breakdown", "negative regulation of protein ubiquitination during ubiquitin-dependent protein degradation", "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism", "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism", "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolism", "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process", "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process"}
{"concept_id": "C3157181", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein degradation tagging activity"}
{"concept_id": "C3157182", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process"}
{"concept_id": "C3157183", "aliases": ["positive regulation of protein ubiquitination during ubiquitin-dependent protein breakdown", "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process", "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism", "positive regulation of protein ubiquitination during ubiquitin-dependent protein degradation", "positive regulation of protein ubiquitination during ubiquitin-dependent protein catabolism", "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism", "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process"}
{"concept_id": "C3157188", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of protein degradation tagging activity"}
{"concept_id": "C3157190", "aliases": [], "types": ["T038"], "canonical_name": "regulation of ureter smooth muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157191", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ureter smooth muscle cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157192", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ureter smooth muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157193", "aliases": ["regulation of cortisol biosynthesis", "regulation of cortisol synthesis", "regulation of cortisol formation"], "types": ["T044"], "canonical_name": "regulation of cortisol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of cortisol biosynthetic process. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157194", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cortisol anabolism"}
{"concept_id": "C3157195", "aliases": ["negative regulation of cortisol biosynthesis", "negative regulation of cortisol synthesis", "negative regulation of cortisol formation"], "types": ["T044"], "canonical_name": "negative regulation of cortisol biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157196", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cortisol anabolism"}
{"concept_id": "C3157197", "aliases": ["positive regulation of cortisol biosynthesis", "positive regulation of cortisol formation", "positive regulation of cortisol synthesis"], "types": ["T044"], "canonical_name": "positive regulation of cortisol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157198", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cortisol anabolism"}
{"concept_id": "C3157199", "aliases": [], "types": ["T038"], "canonical_name": "regulation of root morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of root morphogenesis. [GOC:obol]"}
{"concept_id": "C3157200", "aliases": ["regulation of physiological defense response to insect"], "types": ["T039"], "canonical_name": "regulation of defense response to insect", "definition": "Any process that modulates the frequency, rate or extent of defense response to insect. [GOC:obol]"}
{"concept_id": "C3157201", "aliases": [], "types": ["T040"], "canonical_name": "regulation of post-embryonic root development", "definition": "Any process that modulates the frequency, rate or extent of post-embryonic root development. [GOC:obol]"}
{"concept_id": "C3157202", "aliases": ["regulation of response to thirst", "regulation of response to drought", "regulation of response to dehydration"], "types": ["T039"], "canonical_name": "regulation of response to water deprivation", "definition": "Any process that modulates the frequency, rate or extent of response to water deprivation. [GOC:obol]"}
{"concept_id": "C3157203", "aliases": [], "types": ["T039"], "canonical_name": "regulation of drought tolerance"}
{"concept_id": "C3157204", "aliases": [], "types": ["T040"], "canonical_name": "regulation of defense response by callose deposition", "definition": "Any process that modulates the frequency, rate or extent of defense response by callose deposition. [GOC:obol]"}
{"concept_id": "C3157205", "aliases": [], "types": ["T040"], "canonical_name": "regulation of callose deposition during defense response"}
{"concept_id": "C3157206", "aliases": [], "types": ["T040"], "canonical_name": "regulation of callose localization during defense response"}
{"concept_id": "C3157208", "aliases": ["regulation of site selection involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "regulation of cytokinesis, site selection", "definition": "Any process that modulates the frequency, rate or extent of site selection that occurs as part of cytokinesis. [GOC:mtg_cell_cycle, GOC:obol]"}
{"concept_id": "C3157209", "aliases": ["regulation of pancreatic beta cell development", "regulation of pancreatic B cell development"], "types": ["T043"], "canonical_name": "regulation of type B pancreatic cell development", "definition": "Any process that modulates the frequency, rate or extent of pancreatic B cell development. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157210", "aliases": ["negative regulation of site selection involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "negative regulation of cytokinesis, site selection", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of site selection that occurs as part of cytokinesis. [GOC:mtg_cell_cycle, GOC:obol]"}
{"concept_id": "C3157211", "aliases": ["positive regulation of site selection involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "positive regulation of cytokinesis, site selection", "definition": "Any process that activates or increases the frequency, rate or extent of site selection that occurs as part of cytokinesis. [GOC:mtg_cell_cycle, GOC:obol]"}
{"concept_id": "C3157212", "aliases": ["negative regulation of pancreatic beta cell development", "negative regulation of pancreatic B cell development"], "types": ["T043"], "canonical_name": "negative regulation of type B pancreatic cell development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157213", "aliases": ["positive regulation of pancreatic beta cell development", "positive regulation of pancreatic B cell development"], "types": ["T043"], "canonical_name": "positive regulation of type B pancreatic cell development", "definition": "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157214", "aliases": ["regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation", "regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation", "regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation", "regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation", "regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation", "regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation"], "types": ["T043"], "canonical_name": "regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157215", "aliases": ["negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation", "negative regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation", "negative regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation", "negative regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation", "negative regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation", "negative regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157216", "aliases": ["positive regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation", "positive regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation", "positive regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation", "positive regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation", "positive regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation", "positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157217", "aliases": ["regulation of vitamin C biosynthetic process", "regulation of vitamin C biosynthesis", "regulation of L-ascorbic acid biosynthesis", "regulation of L-ascorbic acid anabolism", "regulation of L-ascorbic acid synthesis", "regulation of ascorbate biosynthesis", "regulation of ascorbate biosynthetic process", "regulation of L-ascorbic acid formation"], "types": ["T044"], "canonical_name": "regulation of L-ascorbic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process. [PMID:19395407]"}
{"concept_id": "C3157218", "aliases": ["negative regulation of ascorbate biosynthetic process", "negative regulation of L-ascorbic acid biosynthesis", "negative regulation of L-ascorbic acid synthesis", "negative regulation of vitamin C biosynthesis", "negative regulation of vitamin C biosynthetic process", "negative regulation of L-ascorbic acid anabolism", "negative regulation of ascorbate biosynthesis", "negative regulation of L-ascorbic acid formation"], "types": ["T044"], "canonical_name": "negative regulation of L-ascorbic acid biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of L-ascorbic acid biosynthetic process. [PMID:19395407]"}
{"concept_id": "C3157219", "aliases": [], "types": ["T038"], "canonical_name": "regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157220", "aliases": [], "types": ["T038"], "canonical_name": "regulation of mesonephric mesenchyme to epithelial transition"}
{"concept_id": "C3157221", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157222", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mesonephric mesenchyme to epithelial transition"}
{"concept_id": "C3157223", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157224", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mesonephric mesenchyme to epithelial transition"}
{"concept_id": "C3157225", "aliases": [], "types": ["T038"], "canonical_name": "regulation of mesonephric glomerulus development", "definition": "Any process that modulates the frequency, rate or extent of mesonephric glomerulus development. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157226", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of mesonephric glomerulus development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157227", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of mesonephric glomerulus development", "definition": "Any process that activates or increases the frequency, rate or extent of mesonephric glomerulus development. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157228", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mesonephric glomerular mesangial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157229", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mesonephric glomerular mesangial cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157230", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mesonephric glomerular mesangial cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157231", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mesonephric nephron tubule epithelial cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157232", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mesonephric nephron tubule epithelial cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3157233", "aliases": ["regulation of Wnt receptor signalling pathway, planar cell polarity pathway", "regulation of Wnt-activated signaling pathway, planar cell polarity pathway", "regulation of PCP pathway", "regulation of Wnt receptor signaling pathway, planar cell polarity pathway"], "types": ["T044"], "canonical_name": "regulation of Wnt signaling pathway, planar cell polarity pathway", "definition": "Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. [GOC:BHF]"}
{"concept_id": "C3157234", "aliases": ["regulation of non-canonical Wnt receptor signaling pathway", "regulation of non-canonical Wnt signaling pathway", "regulation of non-canonical Wnt-activated signaling pathway", "regulation of beta-catenin-independent Wnt receptor signaling pathway", "regulation of non-canonical Wnt receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of non-canonical Wnt signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157235", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Wnt-JNK signaling pathway"}
{"concept_id": "C3157236", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Wnt-PCP signaling pathway"}
{"concept_id": "C3157237", "aliases": ["positive regulation of PCP pathway", "positive regulation of Wnt receptor signalling pathway, planar cell polarity pathway", "positive regulation of Wnt-activated signaling pathway, planar cell polarity pathway", "positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway"], "types": ["T044"], "canonical_name": "positive regulation of Wnt signaling pathway, planar cell polarity pathway", "definition": "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. [GOC:BHF]"}
{"concept_id": "C3157238", "aliases": ["positive regulation of non-canonical Wnt-activated signaling pathway", "positive regulation of non-canonical Wnt receptor signaling pathway", "positive regulation of non-canonical Wnt signaling pathway", "positive regulation of beta-catenin-independent Wnt receptor signaling pathway", "positive regulation of non-canonical Wnt receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of non-canonical Wnt signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157239", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Wnt-JNK signaling pathway"}
{"concept_id": "C3157240", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Wnt-PCP signaling pathway"}
{"concept_id": "C3157241", "aliases": [], "types": ["T043"], "canonical_name": "regulation of smooth muscle cell-matrix adhesion", "definition": "Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion. [GOC:BHF]"}
{"concept_id": "C3157242", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of smooth muscle cell-matrix adhesion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion. [GOC:BHF]"}
{"concept_id": "C3157243", "aliases": [], "types": ["T043"], "canonical_name": "regulation of establishment or maintenance of bipolar cell polarity", "definition": "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity. [GOC:obol]"}
{"concept_id": "C3157244", "aliases": [], "types": ["T043"], "canonical_name": "regulation of establishment or maintenance of bipolar cell polarity regulating cell shape", "definition": "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape. [GOC:obol]"}
{"concept_id": "C3157245", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mammary stem cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of mammary stem cell proliferation. [GOC:obol]"}
{"concept_id": "C3157246", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mammary stem cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation. [GOC:obol]"}
{"concept_id": "C3157247", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mammary stem cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of mammary stem cell proliferation. [GOC:obol]"}
{"concept_id": "C3157248", "aliases": ["negative regulation of DNA-dependent DNA replication"], "types": ["T045"], "canonical_name": "negative regulation of DNA-templated DNA replication", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. [GOC:mah]"}
{"concept_id": "C3157249", "aliases": ["positive regulation of DNA-dependent DNA replication"], "types": ["T045"], "canonical_name": "positive regulation of DNA-templated DNA replication", "definition": "Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication. [GOC:mah]"}
{"concept_id": "C3157250", "aliases": ["regulation of leukocyte apoptosis"], "types": ["T043"], "canonical_name": "regulation of leukocyte apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]"}
{"concept_id": "C3157251", "aliases": ["negative regulation of leukocyte apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]"}
{"concept_id": "C3157252", "aliases": ["positive regulation of leukocyte apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]"}
{"concept_id": "C3157253", "aliases": ["regulation of macrophage apoptosis"], "types": ["T043"], "canonical_name": "regulation of macrophage apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of macrophage apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]"}
{"concept_id": "C3157254", "aliases": ["negative regulation of macrophage apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of macrophage apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]"}
{"concept_id": "C3157255", "aliases": ["positive regulation of macrophage apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of macrophage apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]"}
{"concept_id": "C3157256", "aliases": ["regulation of cellular macromolecule formation", "regulation of cellular macromolecule biosynthesis", "regulation of cellular biopolymer biosynthetic process", "regulation of cellular macromolecule synthesis", "regulation of cellular macromolecule anabolism"], "types": ["T044"], "canonical_name": "regulation of cellular macromolecule biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157257", "aliases": ["negative regulation of cellular macromolecule anabolism", "negative regulation of cellular biopolymer biosynthetic process", "negative regulation of cellular macromolecule biosynthesis", "negative regulation of cellular macromolecule formation", "negative regulation of cellular macromolecule synthesis"], "types": ["T044"], "canonical_name": "negative regulation of cellular macromolecule biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157258", "aliases": ["regulation of cell polarization"], "types": ["T043"], "canonical_name": "regulation of establishment of cell polarity", "definition": "Any process that modulates the frequency, rate or extent of establishment of cell polarity. [GOC:dph]"}
{"concept_id": "C3157259", "aliases": [], "types": ["T043"], "canonical_name": "regulation of bud site selection/establishment of cell polarity"}
{"concept_id": "C3157260", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maintenance of bipolar cell polarity regulating cell shape", "definition": "Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape. [GOC:obol]"}
{"concept_id": "C3157261", "aliases": ["regulation of thiol endopeptidase activity"], "types": ["T044"], "canonical_name": "regulation of cysteine-type endopeptidase activity", "definition": "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157262", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lysosomal cysteine-type endopeptidase"}
{"concept_id": "C3157263", "aliases": ["negative regulation of thiol endopeptidase activity"], "types": ["T044"], "canonical_name": "negative regulation of cysteine-type endopeptidase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157264", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lysosomal cysteine-type endopeptidase"}
{"concept_id": "C3157265", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sodium-dependent phosphate transport", "definition": "Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport. [GOC:BHF]"}
{"concept_id": "C3157266", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of sodium-dependent phosphate transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport. [GOC:BHF]"}
{"concept_id": "C3157267", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of sodium-dependent phosphate transport", "definition": "Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport. [GOC:BHF]"}
{"concept_id": "C3157268", "aliases": ["regulation of removal of oxygen free radicals", "regulation of removal of O2-"], "types": ["T043"], "canonical_name": "regulation of removal of superoxide radicals", "definition": "Any process that modulates the frequency, rate or extent of removal of superoxide radicals. [GOC:obol]"}
{"concept_id": "C3157269", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of stomatal complex development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of stomatal complex development. [GOC:obol]"}
{"concept_id": "C3157270", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of stomatal complex development", "definition": "Any process that activates or increases the frequency, rate or extent of stomatal complex development. [GOC:obol]"}
{"concept_id": "C3157271", "aliases": ["regulation of endocannabinoid signalling pathway"], "types": ["T043"], "canonical_name": "regulation of endocannabinoid signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway. [GOC:mah, PMID:15550444]"}
{"concept_id": "C3157272", "aliases": ["regulation of octopamine/tyramine signaling pathway", "regulation of octopamine or tyramine signalling pathway"], "types": ["T043"], "canonical_name": "regulation of octopamine or tyramine signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of octopamine or tyramine signaling pathway. [GOC:mah]"}
{"concept_id": "C3157273", "aliases": ["negative regulation of octopamine or tyramine signalling pathway", "negative regulation of octopamine/tyramine signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of octopamine or tyramine signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine or tyramine signaling pathway. [GOC:mah]"}
{"concept_id": "C3157274", "aliases": ["positive regulation of octopamine or tyramine signalling pathway", "positive regulation of octopamine/tyramine signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of octopamine or tyramine signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of octopamine or tyramine signaling pathway. [GOC:mah]"}
{"concept_id": "C3157275", "aliases": ["regulation of octopamine signalling pathway"], "types": ["T043"], "canonical_name": "regulation of octopamine signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of octopamine signaling pathway. [GOC:mah]"}
{"concept_id": "C3157276", "aliases": ["negative regulation of octopamine signalling pathway"], "types": ["T043"], "canonical_name": "negative regulation of octopamine signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway. [GOC:mah]"}
{"concept_id": "C3157277", "aliases": ["positive regulation of octopamine signalling pathway"], "types": ["T043"], "canonical_name": "positive regulation of octopamine signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway. [GOC:mah]"}
{"concept_id": "C3157278", "aliases": ["regulation of tyramine signalling pathway"], "types": ["T043"], "canonical_name": "regulation of tyramine signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of tyramine signaling pathway. [GOC:mah]"}
{"concept_id": "C3157279", "aliases": ["negative regulation of tyramine signalling pathway"], "types": ["T043"], "canonical_name": "negative regulation of tyramine signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of tyramine signaling pathway. [GOC:mah]"}
{"concept_id": "C3157280", "aliases": ["positive regulation of tyramine signalling pathway"], "types": ["T043"], "canonical_name": "positive regulation of tyramine signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of tyramine signaling pathway. [GOC:mah]"}
{"concept_id": "C3157281", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of G1/S transition of mitotic cell cycle", "definition": "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3157283", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in heart morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. [GOC:dph]"}
{"concept_id": "C3157284", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell proliferation involved in heart morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. [GOC:dph]"}
{"concept_id": "C3157285", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell proliferation involved in heart morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. [GOC:dph]"}
{"concept_id": "C3157286", "aliases": ["regulation of octopamine signalling pathway involved in response to food"], "types": ["T039"], "canonical_name": "regulation of octopamine signaling pathway involved in response to food", "definition": "Any process that modulates the frequency, rate or extent of octopamine signaling pathway involved in response to food. [GOC:mah, PMID:19609300]"}
{"concept_id": "C3157287", "aliases": ["negative regulation of octopamine signalling pathway involved in response to food"], "types": ["T038"], "canonical_name": "negative regulation of octopamine signaling pathway involved in response to food", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food. [GOC:mah, PMID:19609300]"}
{"concept_id": "C3157288", "aliases": ["positive regulation of octopamine signalling pathway involved in response to food"], "types": ["T038"], "canonical_name": "positive regulation of octopamine signaling pathway involved in response to food", "definition": "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway involved in response to food. [GOC:mah, PMID:19609300]"}
{"concept_id": "C3157289", "aliases": ["regulation of transcription initiation, DNA-dependent", "regulation of DNA-dependent transcription, initiation", "regulation of initiation of DNA-dependent transcription"], "types": ["T045"], "canonical_name": "regulation of DNA-templated transcription, initiation", "definition": "Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C3157290", "aliases": ["negative regulation of transcription initiation, DNA-dependent", "negative regulation of DNA-dependent transcription, initiation", "negative regulation of initiation of DNA-dependent transcription"], "types": ["T045"], "canonical_name": "negative regulation of DNA-templated transcription, initiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C3157291", "aliases": ["positive regulation of initiation of DNA-dependent transcription", "positive regulation of transcription initiation, DNA-dependent", "positive regulation of DNA-dependent transcription, initiation"], "types": ["T045"], "canonical_name": "positive regulation of DNA-templated transcription, initiation", "definition": "Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. [GOC:mah, GOC:txnOH]"}
{"concept_id": "C3157292", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional transactivation"}
{"concept_id": "C3157293", "aliases": ["regulation of movement of a cell", "regulation of cell locomotion"], "types": ["T043"], "canonical_name": "regulation of cell motility", "definition": "Any process that modulates the frequency, rate or extent of cell motility. [GOC:mah]"}
{"concept_id": "C3157294", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell movement"}
{"concept_id": "C3157295", "aliases": ["negative regulation of movement of a cell", "negative regulation of cell locomotion"], "types": ["T043"], "canonical_name": "negative regulation of cell motility", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. [GOC:mah]"}
{"concept_id": "C3157296", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell movement"}
{"concept_id": "C3157297", "aliases": ["positive regulation of movement of a cell", "positive regulation of cell locomotion"], "types": ["T043"], "canonical_name": "positive regulation of cell motility", "definition": "Any process that activates or increases the frequency, rate or extent of cell motility. [GOC:mah]"}
{"concept_id": "C3157298", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell movement"}
{"concept_id": "C3157299", "aliases": [], "types": ["T043"], "canonical_name": "regulation of planar cell polarity pathway involved in ventricular septum morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis. [GOC:dph]"}
{"concept_id": "C3157300", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis. [GOC:dph]"}
{"concept_id": "C3157301", "aliases": [], "types": ["T042"], "canonical_name": "regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis. [GOC:dph]"}
{"concept_id": "C3157302", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis. [GOC:dph]"}
{"concept_id": "C3157303", "aliases": ["regulation of deubiquitinase activity"], "types": ["T044"], "canonical_name": "regulation of ubiquitin-specific protease activity", "definition": "Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity. [GOC:obol]"}
{"concept_id": "C3157304", "aliases": [], "types": ["T044"], "canonical_name": "regulation of UBP"}
{"concept_id": "C3157305", "aliases": [], "types": ["T044"], "canonical_name": "regulation of UCH2"}
{"concept_id": "C3157309", "aliases": ["regulation of cis-Golgi to rough endoplasmic reticulum transport", "regulation of retrograde (Golgi to ER) transport", "regulation of cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport", "regulation of retrograde transport, Golgi to ER", "regulation of cis-Golgi to rough ER transport", "regulation of cis-Golgi to rough ER vesicle-mediated transport", "regulation of retrograde transport, Golgi to endoplasmic reticulum"], "types": ["T043"], "canonical_name": "regulation of retrograde vesicle-mediated transport, Golgi to ER", "definition": "Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER. [GOC:mah]"}
{"concept_id": "C3157310", "aliases": [], "types": ["T043"], "canonical_name": "regulation of retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"}
{"concept_id": "C3157311", "aliases": ["negative regulation of deubiquitinase activity", "negative regulation of ubiquitin hydrolase activity"], "types": ["T044"], "canonical_name": "negative regulation of ubiquitin-specific protease activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity. [GOC:obol]"}
{"concept_id": "C3157312", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of UBP"}
{"concept_id": "C3157313", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of UCH2"}
{"concept_id": "C3157314", "aliases": ["positive regulation of deubiquitinase activity", "positive regulation of ubiquitin hydrolase activity"], "types": ["T044"], "canonical_name": "positive regulation of ubiquitin-specific protease activity", "definition": "Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity. [GOC:obol]"}
{"concept_id": "C3157315", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of UBP"}
{"concept_id": "C3157316", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of UCH2"}
{"concept_id": "C3157317", "aliases": [], "types": ["T044"], "canonical_name": "regulation of planar cell polarity pathway involved in heart morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis. [GOC:dph]"}
{"concept_id": "C3157318", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of planar cell polarity pathway involved in heart morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis. [GOC:dph]"}
{"concept_id": "C3157319", "aliases": [], "types": ["T043"], "canonical_name": "regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis. [GOC:dph]"}
{"concept_id": "C3157320", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis. [GOC:dph]"}
{"concept_id": "C3157321", "aliases": [], "types": ["T043"], "canonical_name": "regulation of planar cell polarity pathway involved in outflow tract morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis. [GOC:dph]"}
{"concept_id": "C3157322", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis. [GOC:dph]"}
{"concept_id": "C3157323", "aliases": [], "types": ["T043"], "canonical_name": "regulation of planar cell polarity pathway involved in pericardium morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis. [GOC:dph]"}
{"concept_id": "C3157324", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of planar cell polarity pathway involved in pericardium morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis. [GOC:dph]"}
{"concept_id": "C3157325", "aliases": [], "types": ["T043"], "canonical_name": "regulation of planar cell polarity pathway involved in neural tube closure", "definition": "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure. [GOC:dph]"}
{"concept_id": "C3157326", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of planar cell polarity pathway involved in neural tube closure", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure. [GOC:dph]"}
{"concept_id": "C3157327", "aliases": [], "types": ["T044"], "canonical_name": "regulation of peptidyl-cysteine S-nitrosylation", "definition": "Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation. [GOC:obol]"}
{"concept_id": "C3157328", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of peptidyl-cysteine S-nitrosylation", "definition": "Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation. [GOC:obol]"}
{"concept_id": "C3157329", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of dendrite development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development. [GOC:obol]"}
{"concept_id": "C3157330", "aliases": [], "types": ["T043"], "canonical_name": "regulation of branching morphogenesis of a nerve", "definition": "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve. [GOC:BHF]"}
{"concept_id": "C3157331", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of branching morphogenesis of a nerve", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve. [GOC:BHF]"}
{"concept_id": "C3157332", "aliases": ["regulation of pro-T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of pro-T cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of pro-T cell differentiation. [GOC:BHF]"}
{"concept_id": "C3157333", "aliases": ["negative regulation of pro-T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of pro-T cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation. [GOC:BHF]"}
{"concept_id": "C3157334", "aliases": ["positive regulation of pro-T lymphocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of pro-T cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation. [GOC:BHF]"}
{"concept_id": "C3157335", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neural precursor cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3157336", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of neural precursor cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3157337", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of neural precursor cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3157338", "aliases": ["negative regulation of androgen biosynthesis", "negative regulation of androgen synthesis", "negative regulation of androgen formation", "negative regulation of androgen anabolism"], "types": ["T044"], "canonical_name": "negative regulation of androgen biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3157339", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of blood vessel morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. [GOC:dph, GOC:yaf]"}
{"concept_id": "C3157340", "aliases": ["regulation of progesterone biosynthesis", "regulation of progesterone formation", "regulation of progesterone synthesis", "regulation of progesterone anabolism"], "types": ["T044"], "canonical_name": "regulation of progesterone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of progesterone biosynthetic process. [GOC:dph]"}
{"concept_id": "C3157341", "aliases": ["negative regulation of progesterone biosynthesis", "negative regulation of progesterone synthesis", "negative regulation of progesterone formation", "negative regulation of progesterone anabolism"], "types": ["T044"], "canonical_name": "negative regulation of progesterone biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process. [GOC:dph]"}
{"concept_id": "C3157342", "aliases": ["positive regulation of progesterone anabolism", "positive regulation of progesterone biosynthesis", "positive regulation of progesterone formation", "positive regulation of progesterone synthesis"], "types": ["T044"], "canonical_name": "positive regulation of progesterone biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process. [GOC:dph]"}
{"concept_id": "C3157343", "aliases": ["regulation of phosphate membrane transport"], "types": ["T043"], "canonical_name": "regulation of phosphate transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport. [GOC:obol]"}
{"concept_id": "C3157344", "aliases": ["negative regulation of phosphate membrane transport"], "types": ["T043"], "canonical_name": "negative regulation of phosphate transmembrane transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport. [GOC:obol]"}
{"concept_id": "C3157345", "aliases": ["positive regulation of phosphate membrane transport"], "types": ["T043"], "canonical_name": "positive regulation of phosphate transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport. [GOC:obol]"}
{"concept_id": "C3157349", "aliases": [], "types": ["T044"], "canonical_name": "regulation of fatty acid transport", "definition": "Any process that modulates the frequency, rate or extent of fatty acid transport. [GOC:BHF]"}
{"concept_id": "C3157350", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of fatty acid transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport. [GOC:BHF]"}
{"concept_id": "C3157351", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of fatty acid transport", "definition": "Any process that activates or increases the frequency, rate or extent of fatty acid transport. [GOC:BHF]"}
{"concept_id": "C3157352", "aliases": ["regulation of ovarian development", "regulation of ovary development"], "types": ["T038"], "canonical_name": "regulation of female gonad development", "definition": "Any process that modulates the frequency, rate or extent of female gonad development. [GOC:obol]"}
{"concept_id": "C3157353", "aliases": ["negative regulation of ovary development", "negative regulation of ovarian development"], "types": ["T038"], "canonical_name": "negative regulation of female gonad development", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. [GOC:obol]"}
{"concept_id": "C3157354", "aliases": ["positive regulation of ovary development", "positive regulation of ovarian development"], "types": ["T038"], "canonical_name": "positive regulation of female gonad development", "definition": "Any process that activates or increases the frequency, rate or extent of female gonad development. [GOC:obol]"}
{"concept_id": "C3157355", "aliases": ["regulation of cellular ribonucleoprotein complex localization", "regulation of establishment and maintenance of ribonucleoprotein complex localization", "regulation of ribonucleoprotein complex localisation", "regulation of RNP localization"], "types": ["T043"], "canonical_name": "regulation of ribonucleoprotein complex localization", "definition": "Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization. [GOC:mah]"}
{"concept_id": "C3157356", "aliases": ["negative regulation of ribonucleoprotein complex localisation", "negative regulation of establishment and maintenance of ribonucleoprotein complex localization", "negative regulation of RNP localization", "negative regulation of cellular ribonucleoprotein complex localization"], "types": ["T043"], "canonical_name": "negative regulation of ribonucleoprotein complex localization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization. [GOC:mah]"}
{"concept_id": "C3157357", "aliases": ["positive regulation of establishment and maintenance of ribonucleoprotein complex localization", "positive regulation of ribonucleoprotein complex localisation", "positive regulation of cellular ribonucleoprotein complex localization", "positive regulation of RNP localization"], "types": ["T043"], "canonical_name": "positive regulation of ribonucleoprotein complex localization", "definition": "Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization. [GOC:mah]"}
{"concept_id": "C3157358", "aliases": ["regulation of ribosomal subunit transport from nucleus to cytoplasm", "regulation of ribosomal subunit export from cell nucleus", "regulation of ribosomal subunit-nucleus export", "regulation of ribosomal subunit export out of nucleus"], "types": ["T043"], "canonical_name": "regulation of ribosomal subunit export from nucleus", "definition": "Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus. [GOC:mah]"}
{"concept_id": "C3157359", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ribosome export from nucleus"}
{"concept_id": "C3157360", "aliases": ["negative regulation of ribosomal subunit export out of nucleus", "negative regulation of ribosomal subunit transport from nucleus to cytoplasm", "negative regulation of ribosomal subunit export from cell nucleus", "negative regulation of ribosomal subunit-nucleus export"], "types": ["T043"], "canonical_name": "negative regulation of ribosomal subunit export from nucleus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal subunit export from nucleus. [GOC:mah]"}
{"concept_id": "C3157361", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ribosome export from nucleus"}
{"concept_id": "C3157362", "aliases": ["positive regulation of ribosomal subunit-nucleus export", "positive regulation of ribosomal subunit export from cell nucleus", "positive regulation of ribosomal subunit export out of nucleus", "positive regulation of ribosomal subunit transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "positive regulation of ribosomal subunit export from nucleus", "definition": "Any process that activates or increases the frequency, rate or extent of ribosomal subunit export from nucleus. [GOC:mah]"}
{"concept_id": "C3157363", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ribosome export from nucleus"}
{"concept_id": "C3157364", "aliases": ["regulation of ribosomal large subunit transport from nucleus to cytoplasm", "regulation of ribosomal large subunit export from cell nucleus", "regulation of ribosomal large subunit-nucleus export", "regulation of ribosomal large subunit export out of nucleus"], "types": ["T043"], "canonical_name": "regulation of ribosomal large subunit export from nucleus", "definition": "Any process that modulates the frequency, rate or extent of ribosomal large subunit export from nucleus. [GOC:mah]"}
{"concept_id": "C3157365", "aliases": [], "types": ["T043"], "canonical_name": "regulation of 50S ribosomal subunit export from nucleus"}
{"concept_id": "C3157366", "aliases": [], "types": ["T043"], "canonical_name": "regulation of 60S ribosomal subunit export from nucleus"}
{"concept_id": "C3157367", "aliases": ["negative regulation of ribosomal large subunit export from cell nucleus", "negative regulation of ribosomal large subunit-nucleus export", "negative regulation of ribosomal large subunit transport from nucleus to cytoplasm", "negative regulation of ribosomal large subunit export out of nucleus"], "types": ["T043"], "canonical_name": "negative regulation of ribosomal large subunit export from nucleus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal large subunit export from nucleus. [GOC:mah]"}
{"concept_id": "C3157368", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of 50S ribosomal subunit export from nucleus"}
{"concept_id": "C3157369", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of 60S ribosomal subunit export from nucleus"}
{"concept_id": "C3157370", "aliases": ["positive regulation of ribosomal large subunit export out of nucleus", "positive regulation of ribosomal large subunit transport from nucleus to cytoplasm", "positive regulation of ribosomal large subunit-nucleus export", "positive regulation of ribosomal large subunit export from cell nucleus"], "types": ["T043"], "canonical_name": "positive regulation of ribosomal large subunit export from nucleus", "definition": "Any process that activates or increases the frequency, rate or extent of ribosomal large subunit export from nucleus. [GOC:mah]"}
{"concept_id": "C3157371", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of 50S ribosomal subunit export from nucleus"}
{"concept_id": "C3157372", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of 60S ribosomal subunit export from nucleus"}
{"concept_id": "C3157373", "aliases": ["regulation of ribosomal small subunit export from cell nucleus", "regulation of ribosomal small subunit export out of nucleus", "regulation of ribosomal small subunit-nucleus export", "regulation of ribosomal small subunit transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "regulation of ribosomal small subunit export from nucleus", "definition": "Any process that modulates the frequency, rate or extent of ribosomal small subunit export from nucleus. [GOC:mah]"}
{"concept_id": "C3157374", "aliases": [], "types": ["T043"], "canonical_name": "regulation of 30S ribosomal subunit export from nucleus"}
{"concept_id": "C3157375", "aliases": [], "types": ["T043"], "canonical_name": "regulation of 40S ribosomal subunit export from nucleus"}
{"concept_id": "C3157376", "aliases": ["negative regulation of ribosomal small subunit-nucleus export", "negative regulation of ribosomal small subunit export from cell nucleus", "negative regulation of ribosomal small subunit transport from nucleus to cytoplasm", "negative regulation of ribosomal small subunit export out of nucleus"], "types": ["T043"], "canonical_name": "negative regulation of ribosomal small subunit export from nucleus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal small subunit export from nucleus. [GOC:mah]"}
{"concept_id": "C3157377", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of 30S ribosomal subunit export from nucleus"}
{"concept_id": "C3157378", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of 40S ribosomal subunit export from nucleus"}
{"concept_id": "C3157379", "aliases": ["positive regulation of 30S ribosomal subunit export from nucleus", "positive regulation of ribosomal small subunit export out of nucleus", "positive regulation of ribosomal small subunit export from cell nucleus", "positive regulation of ribosomal small subunit-nucleus export", "positive regulation of ribosomal small subunit transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "positive regulation of ribosomal small subunit export from nucleus", "definition": "Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus. [GOC:mah]"}
{"concept_id": "C3157380", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of 40S ribosomal subunit export from nucleus"}
{"concept_id": "C3157381", "aliases": ["regulation of suspension induced apoptosis", "regulation of detachment induced cell death"], "types": ["T043"], "canonical_name": "regulation of anoikis", "definition": "Any process that modulates the frequency, rate or extent of anoikis. [GOC:mah]"}
{"concept_id": "C3157382", "aliases": ["positive regulation of suspension induced apoptosis", "positive regulation of detachment induced cell death"], "types": ["T043"], "canonical_name": "positive regulation of anoikis", "definition": "Any process that activates or increases the frequency, rate or extent of anoikis. [GOC:mah]"}
{"concept_id": "C3157383", "aliases": ["regulation of glutamate metabolism", "regulation of glutamic acid metabolic process", "regulation of glutamic acid metabolism"], "types": ["T044"], "canonical_name": "regulation of glutamate metabolic process", "definition": "Any process that modulates the frequency, rate or extent of glutamate metabolic process. [GOC:sl]"}
{"concept_id": "C3157384", "aliases": ["negative regulation of glutamic acid metabolism", "negative regulation of glutamic acid metabolic process", "negative regulation of glutamate metabolism"], "types": ["T043"], "canonical_name": "negative regulation of glutamate metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process. [GOC:sl]"}
{"concept_id": "C3157385", "aliases": ["positive regulation of glutamate metabolism", "positive regulation of glutamic acid metabolism", "positive regulation of glutamic acid metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of glutamate metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of glutamate metabolic process. [GOC:sl]"}
{"concept_id": "C3157386", "aliases": ["regulation of proline metabolism"], "types": ["T044"], "canonical_name": "regulation of proline metabolic process", "definition": "Any process that modulates the frequency, rate or extent of proline metabolic process. [GOC:sl]"}
{"concept_id": "C3157387", "aliases": ["negative regulation of proline metabolism"], "types": ["T043"], "canonical_name": "negative regulation of proline metabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process. [GOC:sl]"}
{"concept_id": "C3157388", "aliases": ["positive regulation of proline metabolism"], "types": ["T043"], "canonical_name": "positive regulation of proline metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of proline metabolic process. [GOC:sl]"}
{"concept_id": "C3157389", "aliases": [], "types": ["T040"], "canonical_name": "regulation of invasive growth in response to glucose limitation", "definition": "Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation. [GOC:mah]"}
{"concept_id": "C3157390", "aliases": [], "types": ["T040"], "canonical_name": "regulation of colony morphology"}
{"concept_id": "C3157391", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of invasive growth in response to glucose limitation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation. [GOC:mah]"}
{"concept_id": "C3157392", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of colony morphology"}
{"concept_id": "C3157393", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of invasive growth in response to glucose limitation", "definition": "Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation. [GOC:mah]"}
{"concept_id": "C3157394", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of colony morphology"}
{"concept_id": "C3157395", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pseudohyphal growth", "definition": "Any process that modulates the frequency, rate or extent of pseudohyphal growth. [GOC:mah]"}
{"concept_id": "C3157396", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of pseudohyphal growth", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth. [GOC:mah]"}
{"concept_id": "C3157397", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of pseudohyphal growth", "definition": "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth. [GOC:mah]"}
{"concept_id": "C3157398", "aliases": ["regulation of BMP signalling pathway involved in heart jogging pathway involved in somitogenesis"], "types": ["T043"], "canonical_name": "regulation of BMP signaling pathway involved in heart jogging", "definition": "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging. [GOC:BHF]"}
{"concept_id": "C3157399", "aliases": [], "types": ["T044"], "canonical_name": "regulation of testosterone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157400", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of testosterone biosynthetic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157401", "aliases": ["regulation of pancreatic alpha cell differentiation"], "types": ["T043"], "canonical_name": "regulation of pancreatic A cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation. [GOC:mah]"}
{"concept_id": "C3157402", "aliases": ["negative regulation of pancreatic alpha cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of pancreatic A cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. [GOC:mah]"}
{"concept_id": "C3157403", "aliases": ["positive regulation of pancreatic alpha cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of pancreatic A cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. [GOC:mah]"}
{"concept_id": "C3157404", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pancreatic stellate cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation. [GOC:mah]"}
{"concept_id": "C3157405", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of pancreatic stellate cell proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation. [GOC:mah]"}
{"concept_id": "C3157406", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of pancreatic stellate cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation. [GOC:mah]"}
{"concept_id": "C3157407", "aliases": [], "types": ["T045"], "canonical_name": "regulation of rRNA processing", "definition": "Any process that modulates the frequency, rate or extent of rRNA processing. [GOC:mah]"}
{"concept_id": "C3157408", "aliases": [], "types": ["T045"], "canonical_name": "regulation of 35S primary transcript processing"}
{"concept_id": "C3157409", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of rRNA processing", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing. [GOC:mah]"}
{"concept_id": "C3157410", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of 35S primary transcript processing"}
{"concept_id": "C3157411", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of rRNA processing", "definition": "Any process that activates or increases the frequency, rate or extent of rRNA processing. [GOC:mah]"}
{"concept_id": "C3157412", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of 35S primary transcript processing"}
{"concept_id": "C3157413", "aliases": ["regulation of tRNA maturation"], "types": ["T045"], "canonical_name": "regulation of tRNA processing", "definition": "Any process that modulates the frequency, rate or extent of tRNA processing. [GOC:mah]"}
{"concept_id": "C3157414", "aliases": ["negative regulation of tRNA maturation"], "types": ["T045"], "canonical_name": "negative regulation of tRNA processing", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA processing. [GOC:mah]"}
{"concept_id": "C3157415", "aliases": ["positive regulation of tRNA maturation"], "types": ["T045"], "canonical_name": "positive regulation of tRNA processing", "definition": "Any process that activates or increases the frequency, rate or extent of tRNA processing. [GOC:mah]"}
{"concept_id": "C3157416", "aliases": ["regulation of tRNA export from cell nucleus", "regulation of tRNA transport from nucleus to cytoplasm", "regulation of tRNA-nucleus export", "regulation of tRNA export out of nucleus"], "types": ["T043"], "canonical_name": "regulation of tRNA export from nucleus", "definition": "Any process that modulates the frequency, rate or extent of tRNA export from nucleus. [GOC:mah]"}
{"concept_id": "C3157417", "aliases": ["negative regulation of tRNA export from cell nucleus", "negative regulation of tRNA transport from nucleus to cytoplasm", "negative regulation of tRNA-nucleus export", "negative regulation of tRNA export out of nucleus"], "types": ["T043"], "canonical_name": "negative regulation of tRNA export from nucleus", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus. [GOC:mah]"}
{"concept_id": "C3157418", "aliases": ["positive regulation of tRNA-nucleus export", "positive regulation of tRNA export out of nucleus", "positive regulation of tRNA export from cell nucleus", "positive regulation of tRNA transport from nucleus to cytoplasm"], "types": ["T043"], "canonical_name": "positive regulation of tRNA export from nucleus", "definition": "Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus. [GOC:mah]"}
{"concept_id": "C3157419", "aliases": [], "types": ["T038"], "canonical_name": "regulation of reproductive process", "definition": "Any process that modulates the frequency, rate or extent of reproductive process. [GOC:mah]"}
{"concept_id": "C3157420", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of reproductive process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. [GOC:mah]"}
{"concept_id": "C3157421", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of reproductive process", "definition": "Any process that activates or increases the frequency, rate or extent of reproductive process. [GOC:mah]"}
{"concept_id": "C3157422", "aliases": ["regulation of prokaryotic fission"], "types": ["T043"], "canonical_name": "regulation of prokaryote-type cytokinesis"}
{"concept_id": "C3157423", "aliases": ["negative regulation of prokaryotic fission"], "types": ["T043"], "canonical_name": "negative regulation of prokaryote-type cytokinesis"}
{"concept_id": "C3157424", "aliases": ["positive regulation of prokaryotic fission"], "types": ["T043"], "canonical_name": "positive regulation of prokaryote-type cytokinesis"}
{"concept_id": "C3157425", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape", "definition": "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape. [GOC:obol]"}
{"concept_id": "C3157426", "aliases": ["negative regulation of establishment and/or maintenance of neuroblast cell polarity"], "types": ["T039"], "canonical_name": "negative regulation of establishment or maintenance of neuroblast polarity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. [GOC:obol]"}
{"concept_id": "C3157427", "aliases": ["regulation of actin cytoskeleton remodeling", "regulation of actin cytoskeleton reorganisation"], "types": ["T043"], "canonical_name": "regulation of actin cytoskeleton reorganization", "definition": "Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization. [GOC:BHF]"}
{"concept_id": "C3157428", "aliases": ["negative regulation of actin cytoskeleton reorganisation", "negative regulation of actin cytoskeleton remodeling"], "types": ["T043"], "canonical_name": "negative regulation of actin cytoskeleton reorganization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of actin cytoskeleton reorganization. [GOC:BHF]"}
{"concept_id": "C3157429", "aliases": ["positive regulation of actin cytoskeleton remodeling", "positive regulation of actin cytoskeleton reorganisation"], "types": ["T043"], "canonical_name": "positive regulation of actin cytoskeleton reorganization", "definition": "Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. [GOC:BHF]"}
{"concept_id": "C3157430", "aliases": ["negative regulation of behavioral response to food", "negative regulation of feeding behaviour", "negative regulation of behavioural response to food"], "types": ["T040"], "canonical_name": "negative regulation of feeding behavior", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior. [GOC:obol]"}
{"concept_id": "C3157431", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of drinking"}
{"concept_id": "C3157432", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of eating"}
{"concept_id": "C3157433", "aliases": ["positive regulation of behavioural response to food", "positive regulation of behavioral response to food", "positive regulation of feeding behaviour"], "types": ["T040"], "canonical_name": "positive regulation of feeding behavior", "definition": "Any process that activates or increases the frequency, rate or extent of feeding behavior. [GOC:obol]"}
{"concept_id": "C3157434", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of drinking"}
{"concept_id": "C3157435", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of eating"}
{"concept_id": "C3157436", "aliases": [], "types": ["T043"], "canonical_name": "regulation of male germ cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of male germ cell proliferation. [GOC:obol]"}
{"concept_id": "C3157437", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of male germ cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation. [GOC:obol]"}
{"concept_id": "C3157438", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of male germ cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of male germ cell proliferation. [GOC:obol]"}
{"concept_id": "C3157439", "aliases": ["regulation of protein activitory cascade", "regulation of protein activation pathway"], "types": ["T039"], "canonical_name": "regulation of protein activation cascade", "definition": "Any process that modulates the frequency, rate or extent of protein activation cascade. [GOC:mah]"}
{"concept_id": "C3157440", "aliases": ["negative regulation of protein activation pathway", "negative regulation of protein activitory cascade"], "types": ["T038"], "canonical_name": "negative regulation of protein activation cascade", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade. [GOC:mah]"}
{"concept_id": "C3157441", "aliases": ["positive regulation of protein activation pathway", "positive regulation of protein activitory cascade"], "types": ["T038"], "canonical_name": "positive regulation of protein activation cascade", "definition": "Any process that activates or increases the frequency, rate or extent of protein activation cascade. [GOC:mah]"}
{"concept_id": "C3157442", "aliases": [], "types": ["T040"], "canonical_name": "regulation of blood coagulation, common pathway", "definition": "Any process that modulates the frequency, rate or extent of blood coagulation, common pathway. [GOC:mah]"}
{"concept_id": "C3157443", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of blood coagulation, common pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway. [GOC:mah]"}
{"concept_id": "C3157444", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of blood coagulation, common pathway", "definition": "Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway. [GOC:mah]"}
{"concept_id": "C3157445", "aliases": [], "types": ["T040"], "canonical_name": "regulation of blood coagulation, extrinsic pathway", "definition": "Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway. [GOC:mah]"}
{"concept_id": "C3157446", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of blood coagulation, extrinsic pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway. [GOC:mah]"}
{"concept_id": "C3157447", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of blood coagulation, extrinsic pathway", "definition": "Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway. [GOC:mah]"}
{"concept_id": "C3157448", "aliases": [], "types": ["T040"], "canonical_name": "regulation of blood coagulation, intrinsic pathway", "definition": "Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway. [GOC:mah]"}
{"concept_id": "C3157449", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of blood coagulation, intrinsic pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway. [GOC:mah]"}
{"concept_id": "C3157450", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of blood coagulation, intrinsic pathway", "definition": "Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway. [GOC:mah]"}
{"concept_id": "C3157451", "aliases": ["regulation of fibroblast apoptosis"], "types": ["T043"], "canonical_name": "regulation of fibroblast apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157452", "aliases": ["negative regulation of fibroblast apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of fibroblast apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157453", "aliases": ["positive regulation of fibroblast apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of fibroblast apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157454", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of receptor activity"}
{"concept_id": "C3157455", "aliases": ["positive regulation of signalling receptor activity"], "types": ["T039"], "canonical_name": "positive regulation of signaling receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of signaling receptor activity. [GOC:obol]"}
{"concept_id": "C3157456", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial cell migration, open tracheal system", "definition": "Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system. [GOC:obol]"}
{"concept_id": "C3157457", "aliases": [], "types": ["T043"], "canonical_name": "regulation of tracheal cell migration"}
{"concept_id": "C3157458", "aliases": [], "types": ["T043"], "canonical_name": "regulation of tracheal epithelial cell migration"}
{"concept_id": "C3157459", "aliases": [], "types": ["T044"], "canonical_name": "regulation of oxidative phosphorylation uncoupler activity", "definition": "Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity. [GOC:mah]"}
{"concept_id": "C3157460", "aliases": [], "types": ["T044"], "canonical_name": "regulation of mitochondrial uncoupling protein activity"}
{"concept_id": "C3157461", "aliases": [], "types": ["T044"], "canonical_name": "regulation of uncoupling protein activity"}
{"concept_id": "C3157462", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of oxidative phosphorylation uncoupler activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity. [GOC:mah]"}
{"concept_id": "C3157463", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of mitochondrial uncoupling protein activity"}
{"concept_id": "C3157464", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of uncoupling protein activity"}
{"concept_id": "C3157465", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of oxidative phosphorylation uncoupler activity", "definition": "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation uncoupler activity. [GOC:mah]"}
{"concept_id": "C3157466", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of mitochondrial uncoupling protein activity"}
{"concept_id": "C3157467", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of uncoupling protein activity"}
{"concept_id": "C3157468", "aliases": ["regulation of DNA synthesis", "regulation of DNA biosynthesis", "regulation of DNA formation", "regulation of DNA anabolism"], "types": ["T045"], "canonical_name": "regulation of DNA biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of DNA biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157469", "aliases": ["negative regulation of DNA synthesis", "negative regulation of DNA biosynthesis", "negative regulation of DNA formation", "negative regulation of DNA anabolism"], "types": ["T043"], "canonical_name": "negative regulation of DNA biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157470", "aliases": [], "types": ["T038"], "canonical_name": "regulation of root development", "definition": "Any process that modulates the frequency, rate or extent of root development. [GOC:obol]"}
{"concept_id": "C3157471", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H3-T3 phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-T3 phosphorylation. [GOC:obol]"}
{"concept_id": "C3157472", "aliases": ["regulation of cellular amino acid biosynthesis", "regulation of cellular amino acid formation", "regulation of cellular amino acid anabolism", "regulation of amino acid biosynthetic process", "regulation of cellular amino acid synthesis"], "types": ["T044"], "canonical_name": "regulation of cellular amino acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157473", "aliases": ["negative regulation of cellular amino acid formation", "negative regulation of cellular amino acid anabolism", "negative regulation of cellular amino acid biosynthesis", "negative regulation of cellular amino acid synthesis", "negative regulation of amino acid biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of cellular amino acid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular amino acid biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157474", "aliases": ["positive regulation of cellular amino acid anabolism", "positive regulation of cellular amino acid biosynthesis", "positive regulation of cellular amino acid formation", "positive regulation of amino acid biosynthetic process", "positive regulation of cellular amino acid synthesis"], "types": ["T044"], "canonical_name": "positive regulation of cellular amino acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157476", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of EPSP"}
{"concept_id": "C3157477", "aliases": ["receptor internalization involved in Wnt receptor signaling pathway through beta-catenin", "receptor internalization involved in canonical Wnt receptor signaling pathway", "receptor internalization involved in Wnt receptor signalling pathway through beta-catenin", "receptor internalization involved in canonical Wnt-activated signaling pathway", "receptor internalization involved in canonical Wnt receptor signalling pathway", "receptor internalization involved in Wnt receptor signaling pathway via beta-catenin"], "types": ["T067"], "canonical_name": "receptor internalization involved in canonical Wnt signaling pathway", "definition": "A receptor internalization process that contributes to canonical Wnt signaling pathway. [GOC:BHF, GOC:mah, PMID:16890161]"}
{"concept_id": "C3157478", "aliases": [], "types": ["T067"], "canonical_name": "receptor internalization involved in frizzled-1 receptor signaling pathway"}
{"concept_id": "C3157479", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of myotome development", "definition": "Any process that activates or increases the frequency, rate or extent of myotome development. [GOC:BHF]"}
{"concept_id": "C3157480", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of myoblast proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of myoblast proliferation. [GOC:BHF]"}
{"concept_id": "C3157481", "aliases": ["regulation of photoreceptor cell axon pathfinding"], "types": ["T042"], "canonical_name": "regulation of photoreceptor cell axon guidance", "definition": "Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance. [GOC:mah]"}
{"concept_id": "C3157482", "aliases": [], "types": ["T040"], "canonical_name": "regulation of myotome development", "definition": "Any process that modulates the frequency, rate or extent of myotome development. [GOC:mah]"}
{"concept_id": "C3157483", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myoblast proliferation", "definition": "Any process that modulates the frequency, rate or extent of myoblast proliferation. [GOC:mah]"}
{"concept_id": "C3157484", "aliases": [], "types": ["T038"], "canonical_name": "regulation of defecation", "definition": "Any process that modulates the frequency, rate or extent of defecation. [GOC:obol]"}
{"concept_id": "C3157485", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of defecation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of defecation. [GOC:obol]"}
{"concept_id": "C3157486", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of defecation", "definition": "Any process that activates or increases the frequency, rate or extent of defecation. [GOC:obol]"}
{"concept_id": "C3157487", "aliases": ["regulation of H2O2 catabolic process", "regulation of hydrogen peroxide degradation", "regulation of hydrogen peroxide catabolism", "regulation of hydrogen peroxide breakdown"], "types": ["T040"], "canonical_name": "regulation of hydrogen peroxide catabolic process", "definition": "Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process. [GOC:BHF]"}
{"concept_id": "C3157488", "aliases": [], "types": ["T040"], "canonical_name": "regulation of detoxification of H2O2"}
{"concept_id": "C3157489", "aliases": [], "types": ["T040"], "canonical_name": "regulation of detoxification of hydrogen peroxide"}
{"concept_id": "C3157490", "aliases": ["regulation of hydrogen peroxide scavenging"], "types": ["T040"], "canonical_name": "regulation of H2O2 scavenging"}
{"concept_id": "C3157491", "aliases": [], "types": ["T040"], "canonical_name": "regulation of hydrogen peroxide removal"}
{"concept_id": "C3157492", "aliases": ["negative regulation of H2O2 catabolic process", "negative regulation of hydrogen peroxide degradation", "negative regulation of hydrogen peroxide breakdown", "negative regulation of hydrogen peroxide catabolism"], "types": ["T044"], "canonical_name": "negative regulation of hydrogen peroxide catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide catabolic process. [GOC:BHF]"}
{"concept_id": "C3157493", "aliases": ["negative regulation of detoxification of hydrogen peroxide"], "types": ["T044"], "canonical_name": "negative regulation of detoxification of H2O2"}
{"concept_id": "C3157494", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of H2O2 scavenging"}
{"concept_id": "C3157495", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of hydrogen peroxide removal"}
{"concept_id": "C3157496", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of hydrogen peroxide scavenging"}
{"concept_id": "C3157497", "aliases": ["negative regulation of synaptic maturation"], "types": ["T043"], "canonical_name": "negative regulation of synapse maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation. [GOC:mah]"}
{"concept_id": "C3157498", "aliases": ["regulation of Rho-associated protein kinase activity", "regulation of ROCK kinase activity"], "types": ["T043"], "canonical_name": "regulation of Rho-dependent protein serine/threonine kinase activity", "definition": "Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity. [GOC:mah]"}
{"concept_id": "C3157499", "aliases": ["negative regulation of Rho-associated protein kinase activity", "negative regulation of ROCK kinase activity"], "types": ["T043"], "canonical_name": "negative regulation of Rho-dependent protein serine/threonine kinase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity. [GOC:mah]"}
{"concept_id": "C3157500", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle exocytosis", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol]"}
{"concept_id": "C3157501", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle exocytosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol]"}
{"concept_id": "C3157502", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle exocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol]"}
{"concept_id": "C3157503", "aliases": ["regulation of ceramide formation", "regulation of ceramide biosynthesis", "regulation of ceramide synthesis", "regulation of ceramide anabolism"], "types": ["T044"], "canonical_name": "regulation of ceramide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process. [GOC:dph]"}
{"concept_id": "C3157504", "aliases": ["positive regulation of ceramide formation", "positive regulation of ceramide anabolism", "positive regulation of ceramide synthesis", "positive regulation of ceramide biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of ceramide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process. [GOC:dph]"}
{"concept_id": "C3157505", "aliases": ["semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon guidance", "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon pathfinding", "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon guidance", "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon pathfinding"], "types": ["T044"], "canonical_name": "semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance", "definition": "Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance. [GOC:obol]"}
{"concept_id": "C3157506", "aliases": ["positive regulation of plant development in response to light"], "types": ["T040"], "canonical_name": "positive regulation of photomorphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of photomorphogenesis. [GOC:obol]"}
{"concept_id": "C3157507", "aliases": ["regulation of RANKL production", "regulation of TNFSF11 production"], "types": ["T040"], "canonical_name": "regulation of tumor necrosis factor (ligand) superfamily member 11 production", "definition": "Any process that modulates the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157508", "aliases": ["negative regulation of TNFSF11 production", "negative regulation of RANKL production"], "types": ["T040"], "canonical_name": "negative regulation of tumor necrosis factor (ligand) superfamily member 11 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157509", "aliases": ["positive regulation of RANKL production", "positive regulation of TNFSF11 production"], "types": ["T040"], "canonical_name": "positive regulation of tumor necrosis factor (ligand) superfamily member 11 production", "definition": "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157510", "aliases": ["regulation of N-methyl-D-aspartate selective glutamate receptor activity"], "types": ["T039"], "canonical_name": "regulation of NMDA receptor activity", "definition": "Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. [GOC:BHF]"}
{"concept_id": "C3157511", "aliases": ["regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity"], "types": ["T039"], "canonical_name": "regulation of AMPA receptor activity", "definition": "Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity. [GOC:BHF]"}
{"concept_id": "C3157512", "aliases": [], "types": ["T039"], "canonical_name": "regulation of kainate selective glutamate receptor activity", "definition": "Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity. [GOC:BHF]"}
{"concept_id": "C3157513", "aliases": ["regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation"], "types": ["T044"], "canonical_name": "regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation", "definition": "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation. [GOC:BHF]"}
{"concept_id": "C3157514", "aliases": ["negative regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation"], "types": ["T044"], "canonical_name": "negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation. [GOC:BHF]"}
{"concept_id": "C3157515", "aliases": ["positive regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation"], "types": ["T044"], "canonical_name": "positive regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation", "definition": "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation. [GOC:BHF]"}
{"concept_id": "C3157516", "aliases": ["regulation of Th17 immune response"], "types": ["T040"], "canonical_name": "regulation of T-helper 17 type immune response", "definition": "Any process that modulates the frequency, rate or extent of T-helper 17 type immune response. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157517", "aliases": ["negative regulation of Th17 immune response"], "types": ["T040"], "canonical_name": "negative regulation of T-helper 17 type immune response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157518", "aliases": ["positive regulation of Th17 immune response"], "types": ["T040"], "canonical_name": "positive regulation of T-helper 17 type immune response", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157519", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T-helper 17 cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157520", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T-helper 17 cell development"}
{"concept_id": "C3157521", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of T-helper 17 cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157522", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of T-helper 17 cell development"}
{"concept_id": "C3157523", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of T-helper 17 cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157524", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of T-helper 17 cell development"}
{"concept_id": "C3157525", "aliases": ["regulation of glucocorticoid receptor signalling pathway"], "types": ["T040"], "canonical_name": "regulation of glucocorticoid receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway. [GOC:BHF]"}
{"concept_id": "C3157526", "aliases": ["negative regulation of glucocorticoid receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of glucocorticoid receptor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway. [GOC:BHF]"}
{"concept_id": "C3157527", "aliases": ["positive regulation of glucocorticoid receptor signalling pathway"], "types": ["T040"], "canonical_name": "positive regulation of glucocorticoid receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway. [GOC:BHF]"}
{"concept_id": "C3157531", "aliases": ["regulation of Th17 fate commitment", "regulation of Th17 cell lineage commitment", "regulation of T-helper 17 cell fate commitment"], "types": ["T043"], "canonical_name": "regulation of T-helper 17 cell lineage commitment", "definition": "Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157532", "aliases": ["negative regulation of T-helper 17 cell fate commitment", "negative regulation of Th17 fate commitment", "negative regulation of Th17 cell lineage commitment"], "types": ["T043"], "canonical_name": "negative regulation of T-helper 17 cell lineage commitment", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157533", "aliases": ["positive regulation of Th17 cell lineage commitment", "positive regulation of T-helper 17 cell fate commitment", "positive regulation of Th17 fate commitment"], "types": ["T043"], "canonical_name": "positive regulation of T-helper 17 cell lineage commitment", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157534", "aliases": ["regulation of synaptic bouton organization", "regulation of terminal button organisation", "regulation of terminal bouton organization", "regulation of bouton organization", "regulation of presynaptic bouton organization"], "types": ["T042"], "canonical_name": "regulation of terminal button organization", "definition": "Any process that modulates the frequency, rate or extent of terminal button organization. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157535", "aliases": ["regulation of microparticle generation", "regulation of microparticle release"], "types": ["T038"], "canonical_name": "regulation of blood microparticle formation", "definition": "Any process that modulates the frequency, rate or extent of blood microparticle formation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157536", "aliases": ["negative regulation of microparticle release", "negative regulation of microparticle generation"], "types": ["T038"], "canonical_name": "negative regulation of blood microparticle formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of blood microparticle formation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157537", "aliases": ["positive regulation of microparticle release", "positive regulation of microparticle generation"], "types": ["T038"], "canonical_name": "positive regulation of blood microparticle formation", "definition": "Any process that activates or increases the frequency, rate or extent of blood microparticle formation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157538", "aliases": ["regulation of endothelial microparticle generation", "regulation of endothelial microparticle release"], "types": ["T038"], "canonical_name": "regulation of endothelial microparticle formation", "definition": "Any process that modulates the frequency, rate or extent of endothelial microparticle formation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157539", "aliases": ["negative regulation of endothelial microparticle generation", "negative regulation of endothelial microparticle release"], "types": ["T038"], "canonical_name": "negative regulation of endothelial microparticle formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial microparticle formation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157540", "aliases": ["positive regulation of endothelial microparticle release", "positive regulation of endothelial microparticle generation"], "types": ["T038"], "canonical_name": "positive regulation of endothelial microparticle formation", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial microparticle formation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157541", "aliases": ["regulation of KC production", "regulation of SCYB1 production", "regulation of keratinocyte derived chemokine production", "regulation of CXCL1 production"], "types": ["T040"], "canonical_name": "regulation of chemokine (C-X-C motif) ligand 1 production", "definition": "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157542", "aliases": ["negative regulation of CXCL1 production", "negative regulation of keratinocyte derived chemokine production", "negative regulation of KC production", "negative regulation of SCYB1 production"], "types": ["T040"], "canonical_name": "negative regulation of chemokine (C-X-C motif) ligand 1 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157543", "aliases": ["positive regulation of CXCL1 production", "positive regulation of keratinocyte derived chemokine production", "positive regulation of KC production", "positive regulation of SCYB1 production"], "types": ["T040"], "canonical_name": "positive regulation of chemokine (C-X-C motif) ligand 1 production", "definition": "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157544", "aliases": ["regulation of CXCL2 production", "regulation of MIP-2 production", "regulation of SCYB2 production", "regulation of MIP2 production"], "types": ["T040"], "canonical_name": "regulation of chemokine (C-X-C motif) ligand 2 production", "definition": "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157545", "aliases": ["negative regulation of MIP-2 production", "negative regulation of CXCL2 production", "negative regulation of SCYB2 production", "negative regulation of MIP2 production"], "types": ["T040"], "canonical_name": "negative regulation of chemokine (C-X-C motif) ligand 2 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157546", "aliases": ["positive regulation of SCYB2 production", "positive regulation of CCL2 secretion", "positive regulation of MIP2 production", "positive regulation of CXCL2 production", "positive regulation of MIP-2 production"], "types": ["T040"], "canonical_name": "positive regulation of chemokine (C-X-C motif) ligand 2 production", "definition": "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157547", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of acrosome reaction", "definition": "Any process that activates or increases the frequency, rate or extent of the acrosome reaction. [GOC:obol]"}
{"concept_id": "C3157548", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hepatocyte proliferation", "definition": "Any process that modulates the frequency, rate or extent of hepatocyte proliferation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157549", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of hepatocyte proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157550", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of hepatocyte proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157551", "aliases": ["regulation of CD40 signalling pathway"], "types": ["T044"], "canonical_name": "regulation of CD40 signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway. [GOC:mah]"}
{"concept_id": "C3157552", "aliases": ["negative regulation of CD40 signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of CD40 signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157553", "aliases": ["positive regulation of CD40 signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of CD40 signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157554", "aliases": ["regulation of endothelial cell apoptosis", "regulation of apoptosis of endothelial cells", "regulation of killing of endothelial cells", "regulation of endothelial cell programmed cell death by apoptosis", "regulation of programmed cell death of endothelial cells by apoptosis", "regulation of programmed cell death, endothelial cells"], "types": ["T043"], "canonical_name": "regulation of endothelial cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. [GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C3157555", "aliases": ["negative regulation of programmed cell death, endothelial cells", "negative regulation of endothelial cell programmed cell death by apoptosis", "negative regulation of killing of endothelial cells", "negative regulation of endothelial cell apoptosis", "negative regulation of programmed cell death of endothelial cells by apoptosis", "negative regulation of apoptosis of endothelial cells"], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C3157556", "aliases": ["positive regulation of endothelial cell programmed cell death by apoptosis", "positive regulation of killing of endothelial cells", "positive regulation of programmed cell death of endothelial cells by apoptosis", "positive regulation of programmed cell death, endothelial cells", "positive regulation of apoptosis of endothelial cells", "positive regulation of endothelial cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of endothelial cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C3157557", "aliases": [], "types": ["T038"], "canonical_name": "regulation of ovarian follicle development", "definition": "Any process that modulates the frequency, rate or extent of ovarian follicle development. [GOC:obol]"}
{"concept_id": "C3157558", "aliases": [], "types": ["T038"], "canonical_name": "regulation of follicular phase"}
{"concept_id": "C3157559", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of ovarian follicle development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian follicle development. [GOC:obol]"}
{"concept_id": "C3157560", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of follicular phase"}
{"concept_id": "C3157561", "aliases": [], "types": ["T043"], "canonical_name": "regulation of kidney smooth muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of kidney smooth muscle cell differentiation. [GOC:obol]"}
{"concept_id": "C3157562", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of kidney smooth muscle cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of kidney smooth muscle cell differentiation. [GOC:obol]"}
{"concept_id": "C3157563", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of kidney smooth muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of kidney smooth muscle cell differentiation. [GOC:obol]"}
{"concept_id": "C3157564", "aliases": [], "types": ["T043"], "canonical_name": "regulation of binding of sperm to zona pellucida", "definition": "Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida. [GOC:obol]"}
{"concept_id": "C3157565", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ZPG binding"}
{"concept_id": "C3157566", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of binding of sperm to zona pellucida", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida. [GOC:obol]"}
{"concept_id": "C3157567", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ZPG binding"}
{"concept_id": "C3157568", "aliases": ["regulation of prostaglandin endoperoxide E2 isomerase activity", "regulation of prostaglandin-H2 E-isomerase activity", "regulation of prostaglandin H-E isomerase activity", "regulation of prostaglandin endoperoxide E isomerase activity", "regulation of endoperoxide isomerase activity", "regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity", "regulation of prostaglandin R-prostaglandin E isomerase activity", "regulation of PGE isomerase activity", "regulation of Prostaglandin-H(2) E-isomerase activity", "regulation of PGH-PGE isomerase activity", "regulation of PGE2 isomerase activity"], "types": ["T044"], "canonical_name": "regulation of prostaglandin-E synthase activity", "definition": "Any process that modulates the frequency, rate or extent of prostaglandin-E synthase activity. [GOC:BHF]"}
{"concept_id": "C3157569", "aliases": ["negative regulation of prostaglandin-H2 E-isomerase activity", "negative regulation of endoperoxide isomerase activity", "negative regulation of PGE isomerase activity", "negative regulation of Prostaglandin-H(2) E-isomerase activity", "negative regulation of prostaglandin endoperoxide E2 isomerase activity", "negative regulation of prostaglandin endoperoxide E isomerase activity", "negative regulation of PGH-PGE isomerase activity", "negative regulation of prostaglandin R-prostaglandin E isomerase activity", "negative regulation of PGE2 isomerase activity", "negative regulation of prostaglandin H-E isomerase activity", "negative regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity"], "types": ["T044"], "canonical_name": "negative regulation of prostaglandin-E synthase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin-E synthase activity. [GOC:BHF]"}
{"concept_id": "C3157570", "aliases": ["positive regulation of prostaglandin endoperoxide E2 isomerase activity", "positive regulation of endoperoxide isomerase activity", "positive regulation of PGE isomerase activity", "positive regulation of prostaglandin H-E isomerase activity", "positive regulation of PGE2 isomerase activity", "positive regulation of prostaglandin endoperoxide E isomerase activity", "positive regulation of prostaglandin R-prostaglandin E isomerase activity", "positive regulation of Prostaglandin-H(2) E-isomerase activity", "positive regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity", "positive regulation of prostaglandin-H2 E-isomerase activity", "positive regulation of PGH-PGE isomerase activity"], "types": ["T044"], "canonical_name": "positive regulation of prostaglandin-E synthase activity", "definition": "Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity. [GOC:BHF]"}
{"concept_id": "C3157577", "aliases": ["regulation of acrosome exocytosis"], "types": ["T043"], "canonical_name": "regulation of acrosomal vesicle exocytosis", "definition": "Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis. [GOC:obol]"}
{"concept_id": "C3157578", "aliases": [], "types": ["T043"], "canonical_name": "regulation of acrosomal granule exocytosis"}
{"concept_id": "C3157579", "aliases": ["positive regulation of acrosome exocytosis"], "types": ["T043"], "canonical_name": "positive regulation of acrosomal vesicle exocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of acrosomal vesicle exocytosis. [GOC:obol]"}
{"concept_id": "C3157580", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of acrosomal granule exocytosis"}
{"concept_id": "C3157581", "aliases": ["regulation of clathrin coated pit-dependent endocytosis", "regulation of clathrin-mediated endocytosis"], "types": ["T043"], "canonical_name": "regulation of clathrin-dependent endocytosis", "definition": "Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. [GOC:mah]"}
{"concept_id": "C3157582", "aliases": ["positive regulation of clathrin-mediated endocytosis", "positive regulation of clathrin coated pit-dependent endocytosis"], "types": ["T043"], "canonical_name": "positive regulation of clathrin-dependent endocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157583", "aliases": ["regulation of topoisomerase II", "regulation of DNA topoisomerase type II activity", "regulation of type II DNA topoisomerase activity", "regulation of DNA topoisomerase IV activity", "regulation of deoxyribonucleic topoisomerase activity"], "types": ["T044"], "canonical_name": "regulation of DNA topoisomerase (ATP-hydrolyzing) activity", "definition": "Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. [GOC:mah]"}
{"concept_id": "C3157584", "aliases": [], "types": ["T044"], "canonical_name": "regulation of deoxyribonucleate topoisomerase"}
{"concept_id": "C3157585", "aliases": [], "types": ["T044"], "canonical_name": "regulation of DNA topoisomerase (ATP-hydrolysing)"}
{"concept_id": "C3157586", "aliases": [], "types": ["T044"], "canonical_name": "regulation of DNA topoisomerase II"}
{"concept_id": "C3157587", "aliases": [], "types": ["T044"], "canonical_name": "regulation of topoisomerase"}
{"concept_id": "C3157588", "aliases": ["negative regulation of deoxyribonucleic topoisomerase activity", "negative regulation of DNA topoisomerase type II activity", "negative regulation of topoisomerase II", "negative regulation of type II DNA topoisomerase activity", "negative regulation of DNA topoisomerase IV activity"], "types": ["T044"], "canonical_name": "negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. [GOC:mah]"}
{"concept_id": "C3157589", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of deoxyribonucleate topoisomerase"}
{"concept_id": "C3157590", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of DNA topoisomerase (ATP-hydrolysing)"}
{"concept_id": "C3157591", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of DNA topoisomerase II"}
{"concept_id": "C3157592", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of topoisomerase"}
{"concept_id": "C3157593", "aliases": ["positive regulation of DNA topoisomerase IV activity", "positive regulation of topoisomerase II", "positive regulation of type II DNA topoisomerase activity", "positive regulation of DNA topoisomerase type II activity", "positive regulation of deoxyribonucleic topoisomerase activity"], "types": ["T044"], "canonical_name": "positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity", "definition": "Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. [GOC:mah]"}
{"concept_id": "C3157594", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of deoxyribonucleate topoisomerase"}
{"concept_id": "C3157595", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of DNA topoisomerase (ATP-hydrolysing)"}
{"concept_id": "C3157596", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of DNA topoisomerase II"}
{"concept_id": "C3157597", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of topoisomerase"}
{"concept_id": "C3157598", "aliases": ["regulation of oxygen metabolism", "regulation of diatomic oxygen metabolic process"], "types": ["T040"], "canonical_name": "regulation of oxygen metabolic process", "definition": "Any process that modulates the frequency, rate or extent of oxygen metabolic process. [GOC:mah]"}
{"concept_id": "C3157599", "aliases": ["negative regulation of diatomic oxygen metabolic process", "negative regulation of oxygen metabolism"], "types": ["T044"], "canonical_name": "negative regulation of oxygen metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. [GOC:mah]"}
{"concept_id": "C3157600", "aliases": ["positive regulation of diatomic oxygen metabolic process", "positive regulation of oxygen metabolism"], "types": ["T044"], "canonical_name": "positive regulation of oxygen metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. [GOC:mah]"}
{"concept_id": "C3157601", "aliases": ["regulation of reactive oxygen species metabolism", "regulation of ROS metabolic process"], "types": ["T040"], "canonical_name": "regulation of reactive oxygen species metabolic process", "definition": "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]"}
{"concept_id": "C3157602", "aliases": ["negative regulation of ROS metabolic process", "negative regulation of reactive oxygen species metabolism"], "types": ["T044"], "canonical_name": "negative regulation of reactive oxygen species metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]"}
{"concept_id": "C3157603", "aliases": ["positive regulation of reactive oxygen species metabolism", "positive regulation of ROS metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of reactive oxygen species metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]"}
{"concept_id": "C3157604", "aliases": [], "types": ["T038"], "canonical_name": "regulation of mesoderm development", "definition": "Any process that modulates the frequency, rate or extent of mesoderm development. [GOC:BHF]"}
{"concept_id": "C3157605", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of mesoderm development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. [GOC:BHF]"}
{"concept_id": "C3157606", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of mesoderm development", "definition": "Any process that activates or increases the frequency, rate or extent of mesoderm development. [GOC:BHF]"}
{"concept_id": "C3157607", "aliases": [], "types": ["T038"], "canonical_name": "regulation of ectoderm development", "definition": "Any process that modulates the frequency, rate or extent of ectoderm development. [GOC:BHF]"}
{"concept_id": "C3157608", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of ectoderm development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. [GOC:BHF]"}
{"concept_id": "C3157609", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of ectoderm development", "definition": "Any process that activates or increases the frequency, rate or extent of ectoderm development. [GOC:BHF]"}
{"concept_id": "C3157610", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of ovarian follicle development", "definition": "Any process that activates or increases the frequency, rate or extent of ovarian follicle development. [GOC:obol]"}
{"concept_id": "C3157611", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of follicular phase"}
{"concept_id": "C3157612", "aliases": [], "types": ["T040"], "canonical_name": "regulation of antral ovarian follicle growth", "definition": "Any process that modulates the frequency, rate or extent of antral ovarian follicle growth. [GOC:obol]"}
{"concept_id": "C3157613", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of antral ovarian follicle growth", "definition": "Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth. [GOC:obol]"}
{"concept_id": "C3157614", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil extravasation", "definition": "Any process that modulates the frequency, rate or extent of neutrophil extravasation. [GOC:mah]"}
{"concept_id": "C3157615", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of neutrophil extravasation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil extravasation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157616", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of neutrophil extravasation", "definition": "Any process that activates or increases the frequency, rate or extent of neutrophil extravasation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157617", "aliases": [], "types": ["T038"], "canonical_name": "regulation of lamellipodium morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis. [GOC:mah]"}
{"concept_id": "C3157618", "aliases": ["regulation of lamellipodium organization"], "types": ["T043"], "canonical_name": "regulation of lamellipodium organization", "definition": "Any process that modulates the frequency, rate or extent of lamellipodium organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]"}
{"concept_id": "C3157619", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of lamellipodium morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157620", "aliases": ["down-regulation of lamellipodium organization", "downregulation of lamellipodium organization", "down regulation of lamellipodium organization", "negative regulation of lamellipodium organization"], "types": ["T043"], "canonical_name": "negative regulation of lamellipodium organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]"}
{"concept_id": "C3157621", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of lamellipodium morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157622", "aliases": ["positive regulation of lamellipodium organization", "up-regulation of lamellipodium organization", "up regulation of lamellipodium organization", "upregulation of lamellipodium organization"], "types": ["T043"], "canonical_name": "positive regulation of lamellipodium organization", "definition": "Any process that activates or increases the frequency, rate or extent of lamellipodium organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]"}
{"concept_id": "C3157623", "aliases": ["regulation of ubiquitin-mediated endocytosis"], "types": ["T043"], "canonical_name": "regulation of ubiquitin-dependent endocytosis", "definition": "Any process that modulates the frequency, rate or extent of ubiquitin-dependent endocytosis. [GOC:mah]"}
{"concept_id": "C3157624", "aliases": ["negative regulation of ubiquitin-mediated endocytosis"], "types": ["T043"], "canonical_name": "negative regulation of ubiquitin-dependent endocytosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis. [GOC:mah]"}
{"concept_id": "C3157625", "aliases": ["positive regulation of ubiquitin-mediated endocytosis"], "types": ["T043"], "canonical_name": "positive regulation of ubiquitin-dependent endocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis. [GOC:mah]"}
{"concept_id": "C3157626", "aliases": ["regulation of T cell precursor aggregation", "regulation of immature T-lymphocyte aggregation", "regulation of thymic lymphocyte aggregation"], "types": ["T043"], "canonical_name": "regulation of thymocyte aggregation", "definition": "Any process that modulates the frequency, rate or extent of thymocyte aggregation. [GOC:mah]"}
{"concept_id": "C3157627", "aliases": ["regulation of immature T-cell aggregation"], "types": ["T043"], "canonical_name": "regulation of immature T cell aggregation"}
{"concept_id": "C3157628", "aliases": ["negative regulation of immature T-lymphocyte aggregation", "negative regulation of T cell precursor aggregation", "negative regulation of thymic lymphocyte aggregation"], "types": ["T043"], "canonical_name": "negative regulation of thymocyte aggregation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157629", "aliases": ["negative regulation of immature T-cell aggregation"], "types": ["T043"], "canonical_name": "negative regulation of immature T cell aggregation"}
{"concept_id": "C3157630", "aliases": ["positive regulation of immature T-lymphocyte aggregation", "positive regulation of thymic lymphocyte aggregation", "positive regulation of T cell precursor aggregation"], "types": ["T043"], "canonical_name": "positive regulation of thymocyte aggregation", "definition": "Any process that activates or increases the frequency, rate or extent of thymocyte aggregation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157631", "aliases": ["positive regulation of immature T-cell aggregation"], "types": ["T043"], "canonical_name": "positive regulation of immature T cell aggregation"}
{"concept_id": "C3157632", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lymphocyte migration", "definition": "Any process that modulates the frequency, rate or extent of lymphocyte migration. [GOC:mah]"}
{"concept_id": "C3157633", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of lymphocyte migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration. [GOC:mah]"}
{"concept_id": "C3157634", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of lymphocyte migration", "definition": "Any process that activates or increases the frequency, rate or extent of lymphocyte migration. [GOC:mah]"}
{"concept_id": "C3157635", "aliases": ["regulation of T-cell migration", "regulation of T-lymphocyte migration", "regulation of T lymphocyte migration"], "types": ["T043"], "canonical_name": "regulation of T cell migration", "definition": "Any process that modulates the frequency, rate or extent of T cell migration. [GOC:mah]"}
{"concept_id": "C3157636", "aliases": ["negative regulation of T-lymphocyte migration", "negative regulation of T-cell migration", "negative regulation of T lymphocyte migration"], "types": ["T043"], "canonical_name": "negative regulation of T cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration. [GOC:mah]"}
{"concept_id": "C3157637", "aliases": ["positive regulation of T lymphocyte migration", "positive regulation of T-cell migration", "positive regulation of T-lymphocyte migration"], "types": ["T043"], "canonical_name": "positive regulation of T cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of T cell migration. [GOC:mah]"}
{"concept_id": "C3157638", "aliases": ["regulation of T-cell extravasation", "regulation of T lymphocyte extravasation", "regulation of T-lymphocyte extravasation"], "types": ["T043"], "canonical_name": "regulation of T cell extravasation", "definition": "Any process that modulates the frequency, rate or extent of T cell extravasation. [GOC:mah]"}
{"concept_id": "C3157639", "aliases": ["negative regulation of T lymphocyte extravasation", "negative regulation of T-lymphocyte extravasation", "negative regulation of T-cell extravasation"], "types": ["T043"], "canonical_name": "negative regulation of T cell extravasation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T cell extravasation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157640", "aliases": ["positive regulation of T-lymphocyte extravasation", "positive regulation of T lymphocyte extravasation", "positive regulation of T-cell extravasation"], "types": ["T043"], "canonical_name": "positive regulation of T cell extravasation", "definition": "Any process that activates or increases the frequency, rate or extent of T cell extravasation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157641", "aliases": ["regulation of thymic lymphocyte migration"], "types": ["T043"], "canonical_name": "regulation of thymocyte migration", "definition": "Any process that modulates the frequency, rate or extent of thymocyte migration. [GOC:mah]"}
{"concept_id": "C3157642", "aliases": ["regulation of immature T-cell migration"], "types": ["T043"], "canonical_name": "regulation of immature T cell migration"}
{"concept_id": "C3157643", "aliases": ["regulation of immature T-lymphocyte migration"], "types": ["T043"], "canonical_name": "regulation of immature T lymphocyte migration"}
{"concept_id": "C3157644", "aliases": ["negative regulation of thymic lymphocyte migration"], "types": ["T043"], "canonical_name": "negative regulation of thymocyte migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte migration. [GOC:mah]"}
{"concept_id": "C3157645", "aliases": ["negative regulation of immature T-cell migration"], "types": ["T043"], "canonical_name": "negative regulation of immature T cell migration"}
{"concept_id": "C3157646", "aliases": ["negative regulation of immature T-lymphocyte migration"], "types": ["T043"], "canonical_name": "negative regulation of immature T lymphocyte migration"}
{"concept_id": "C3157647", "aliases": ["positive regulation of thymic lymphocyte migration"], "types": ["T043"], "canonical_name": "positive regulation of thymocyte migration", "definition": "Any process that activates or increases the frequency, rate or extent of thymocyte migration. [GOC:mah]"}
{"concept_id": "C3157648", "aliases": ["positive regulation of immature T-cell migration"], "types": ["T043"], "canonical_name": "positive regulation of immature T cell migration"}
{"concept_id": "C3157649", "aliases": ["positive regulation of immature T-lymphocyte migration"], "types": ["T043"], "canonical_name": "positive regulation of immature T lymphocyte migration"}
{"concept_id": "C3157650", "aliases": ["regulation of fibronectin-dependent thymic lymphocyte migration"], "types": ["T043"], "canonical_name": "regulation of fibronectin-dependent thymocyte migration", "definition": "Any process that modulates the frequency, rate or extent of fibronectin-dependent thymocyte migration. [GOC:mah]"}
{"concept_id": "C3157651", "aliases": ["regulation of fibronectin-dependent immature T-cell migration"], "types": ["T043"], "canonical_name": "regulation of fibronectin-dependent immature T cell migration"}
{"concept_id": "C3157652", "aliases": ["regulation of fibronectin-dependent immature T-lymphocyte migration"], "types": ["T043"], "canonical_name": "regulation of fibronectin-dependent immature T lymphocyte migration"}
{"concept_id": "C3157653", "aliases": ["negative regulation of fibronectin-dependent thymic lymphocyte migration"], "types": ["T043"], "canonical_name": "negative regulation of fibronectin-dependent thymocyte migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fibronectin-dependent thymocyte migration. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157654", "aliases": ["negative regulation of fibronectin-dependent immature T-cell migration"], "types": ["T043"], "canonical_name": "negative regulation of fibronectin-dependent immature T cell migration"}
{"concept_id": "C3157655", "aliases": ["negative regulation of fibronectin-dependent immature T-lymphocyte migration"], "types": ["T043"], "canonical_name": "negative regulation of fibronectin-dependent immature T lymphocyte migration"}
{"concept_id": "C3157656", "aliases": ["positive regulation of fibronectin-dependent thymic lymphocyte migration"], "types": ["T043"], "canonical_name": "positive regulation of fibronectin-dependent thymocyte migration", "definition": "Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157657", "aliases": ["positive regulation of fibronectin-dependent immature T-cell migration"], "types": ["T043"], "canonical_name": "positive regulation of fibronectin-dependent immature T cell migration"}
{"concept_id": "C3157658", "aliases": ["positive regulation of fibronectin-dependent immature T-lymphocyte migration"], "types": ["T043"], "canonical_name": "positive regulation of fibronectin-dependent immature T lymphocyte migration"}
{"concept_id": "C3157659", "aliases": [], "types": ["T043"], "canonical_name": "regulation of eosinophil migration", "definition": "Any process that modulates the frequency, rate or extent of eosinophil migration. [GOC:mah]"}
{"concept_id": "C3157660", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of eosinophil migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration. [GOC:mah]"}
{"concept_id": "C3157661", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of eosinophil migration", "definition": "Any process that activates or increases the frequency, rate or extent of eosinophil migration. [GOC:mah]"}
{"concept_id": "C3157662", "aliases": [], "types": ["T043"], "canonical_name": "regulation of eosinophil extravasation", "definition": "Any process that modulates the frequency, rate or extent of eosinophil extravasation. [GOC:mah]"}
{"concept_id": "C3157663", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of eosinophil extravasation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil extravasation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157664", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of eosinophil extravasation", "definition": "Any process that activates or increases the frequency, rate or extent of eosinophil extravasation. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3157665", "aliases": [], "types": ["T043"], "canonical_name": "regulation of eosinophil chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of eosinophil chemotaxis. [GOC:obol]"}
{"concept_id": "C3157666", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of eosinophil chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis. [GOC:obol]"}
{"concept_id": "C3157667", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of eosinophil chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis. [GOC:obol]"}
{"concept_id": "C3157668", "aliases": ["regulation of apoptotic cell removal", "regulation of efferocytosis", "regulation of programmed cell clearance"], "types": ["T043"], "canonical_name": "regulation of apoptotic cell clearance", "definition": "Any process that modulates the frequency, rate or extent of apoptotic cell clearance. [GOC:obol]"}
{"concept_id": "C3157669", "aliases": ["negative regulation of efferocytosis", "negative regulation of programmed cell clearance", "negative regulation of apoptotic cell removal"], "types": ["T043"], "canonical_name": "negative regulation of apoptotic cell clearance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance. [GOC:obol]"}
{"concept_id": "C3157670", "aliases": ["positive regulation of efferocytosis", "positive regulation of programmed cell clearance", "positive regulation of apoptotic cell removal"], "types": ["T043"], "canonical_name": "positive regulation of apoptotic cell clearance", "definition": "Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance. [GOC:obol]"}
{"concept_id": "C3157671", "aliases": ["regulation of neutrocyte aggregation", "regulation of neutrophil leucocyte aggregation", "regulation of neutrophilic leukocyte aggregation"], "types": ["T043"], "canonical_name": "regulation of neutrophil aggregation", "definition": "Any process that modulates the frequency, rate or extent of neutrophil aggregation. [GOC:BHF]"}
{"concept_id": "C3157672", "aliases": ["negative regulation of neutrocyte aggregation", "negative regulation of neutrophilic leukocyte aggregation", "negative regulation of neutrophil leucocyte aggregation"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil aggregation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation. [GOC:BHF]"}
{"concept_id": "C3157673", "aliases": ["positive regulation of neutrocyte aggregation", "positive regulation of neutrophil leucocyte aggregation", "positive regulation of neutrophilic leukocyte aggregation"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil aggregation", "definition": "Any process that activates or increases the frequency, rate or extent of neutrophil aggregation. [GOC:BHF]"}
{"concept_id": "C3157674", "aliases": ["regulation of contractile ring assembly"], "types": ["T043"], "canonical_name": "regulation of cytokinesis, actomyosin contractile ring assembly", "definition": "Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly. [GOC:obol]"}
{"concept_id": "C3157675", "aliases": ["negative regulation of contractile ring assembly"], "types": ["T043"], "canonical_name": "negative regulation of cytokinesis, actomyosin contractile ring assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly. [GOC:obol]"}
{"concept_id": "C3157676", "aliases": ["positive regulation of contractile ring assembly"], "types": ["T043"], "canonical_name": "positive regulation of cytokinesis, actomyosin contractile ring assembly", "definition": "Any process that activates or increases the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly. [GOC:obol]"}
{"concept_id": "C3157677", "aliases": ["regulation of RUB1-protein conjugation"], "types": ["T044"], "canonical_name": "regulation of protein neddylation", "definition": "Any process that modulates the frequency, rate or extent of protein neddylation. [GOC:obol]"}
{"concept_id": "C3157678", "aliases": ["negative regulation of RUB1-protein conjugation"], "types": ["T044"], "canonical_name": "negative regulation of protein neddylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation. [GOC:obol]"}
{"concept_id": "C3157679", "aliases": ["positive regulation of RUB1-protein conjugation"], "types": ["T044"], "canonical_name": "positive regulation of protein neddylation", "definition": "Any process that activates or increases the frequency, rate or extent of protein neddylation. [GOC:obol]"}
{"concept_id": "C3157680", "aliases": [], "types": ["T043"], "canonical_name": "regulation of monocyte extravasation", "definition": "Any process that modulates the frequency, rate or extent of monocyte extravasation. [GOC:obol]"}
{"concept_id": "C3157681", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of monocyte extravasation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte extravasation. [GOC:obol]"}
{"concept_id": "C3157682", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of monocyte extravasation", "definition": "Any process that activates or increases the frequency, rate or extent of monocyte extravasation. [GOC:obol]"}
{"concept_id": "C3157683", "aliases": ["regulation of toll-like receptor 15 signalling pathway", "regulation of TLR15 signaling pathway"], "types": ["T044"], "canonical_name": "regulation of toll-like receptor 15 signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway. [GOC:obol]"}
{"concept_id": "C3157684", "aliases": ["negative regulation of TLR15 signaling pathway", "negative regulation of toll-like receptor 15 signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 15 signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 15 signaling pathway. [GOC:obol]"}
{"concept_id": "C3157685", "aliases": ["positive regulation of toll-like receptor 15 signalling pathway", "positive regulation of TLR15 signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 15 signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of toll-like receptor 15 signaling pathway. [GOC:obol]"}
{"concept_id": "C3157686", "aliases": ["regulation of toll-like receptor 21 signalling pathway", "regulation of TLR21 signaling pathway"], "types": ["T044"], "canonical_name": "regulation of toll-like receptor 21 signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of toll-like receptor 21 signaling pathway. [GOC:obol]"}
{"concept_id": "C3157687", "aliases": ["negative regulation of toll-like receptor 21 signalling pathway", "negative regulation of TLR21 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of toll-like receptor 21 signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 21 signaling pathway. [GOC:obol]"}
{"concept_id": "C3157688", "aliases": ["positive regulation of toll-like receptor 21 signalling pathway", "positive regulation of TLR21 signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 21 signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of toll-like receptor 21 signaling pathway. [GOC:obol]"}
{"concept_id": "C3157689", "aliases": ["regulation of macrophage migration inhibitory factor signalling pathway", "regulation of MIF signaling pathway"], "types": ["T044"], "canonical_name": "regulation of macrophage migration inhibitory factor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway. [GOC:obol]"}
{"concept_id": "C3157690", "aliases": ["negative regulation of MIF signaling pathway", "negative regulation of macrophage migration inhibitory factor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of macrophage migration inhibitory factor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway. [GOC:obol]"}
{"concept_id": "C3157691", "aliases": ["positive regulation of macrophage migration inhibitory factor signalling pathway", "positive regulation of MIF signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of macrophage migration inhibitory factor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway. [GOC:obol]"}
{"concept_id": "C3157692", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CD8-positive, alpha-beta T cell extravasation", "definition": "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation. [GOC:obol]"}
{"concept_id": "C3157693", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CD8-positive, alpha-beta T cell extravasation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation. [GOC:obol]"}
{"concept_id": "C3157694", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CD8-positive, alpha-beta T cell extravasation", "definition": "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation. [GOC:obol]"}
{"concept_id": "C3157695", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation", "definition": "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation. [GOC:obol]"}
{"concept_id": "C3157696", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation. [GOC:obol]"}
{"concept_id": "C3157697", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation", "definition": "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation. [GOC:obol]"}
{"concept_id": "C3157698", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T-helper 17 cell extravasation", "definition": "Any process that modulates the frequency, rate or extent of T-helper 17 cell extravasation. [GOC:obol]"}
{"concept_id": "C3157699", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of T-helper 17 cell extravasation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell extravasation. [GOC:obol]"}
{"concept_id": "C3157700", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of T-helper 17 cell extravasation", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell extravasation. [GOC:obol]"}
{"concept_id": "C3157701", "aliases": [], "types": ["T043"], "canonical_name": "regulation of astrocyte chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of astrocyte chemotaxis. [GOC:obol]"}
{"concept_id": "C3157702", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of astrocyte chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis. [GOC:obol]"}
{"concept_id": "C3157706", "aliases": ["positive regulation of EPSP", "positive regulation of excitatory post-synaptic membrane potential"], "types": ["T043"], "canonical_name": "positive regulation of excitatory postsynaptic potential", "definition": "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:bf, GOC:BHF]"}
{"concept_id": "C3157707", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of astrocyte chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis. [GOC:obol]"}
{"concept_id": "C3157708", "aliases": ["regulation of glycogen (starch) synthetase activity", "regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity", "regulation of UDP-glycogen synthase activity", "regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity", "regulation of UDPG-glycogen transglucosylase activity", "regulation of UDPG-glycogen synthetase activity", "regulation of UDP-glucose-glycogen glucosyltransferase activity", "regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "regulation of glycogen (starch) synthase activity", "definition": "Any process that modulates the frequency, rate or extent of glycogen (starch) synthase activity. [GOC:obol]"}
{"concept_id": "C3157709", "aliases": ["negative regulation of UDP-glycogen synthase activity", "negative regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity", "negative regulation of glycogen (starch) synthetase activity", "negative regulation of UDP-glucose-glycogen glucosyltransferase activity", "negative regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity", "negative regulation of UDPG-glycogen transglucosylase activity", "negative regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity", "negative regulation of UDPG-glycogen synthetase activity"], "types": ["T044"], "canonical_name": "negative regulation of glycogen (starch) synthase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen (starch) synthase activity. [GOC:obol]"}
{"concept_id": "C3157710", "aliases": ["positive regulation of UDP-glycogen synthase activity", "positive regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity", "positive regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity", "positive regulation of UDP-glucose-glycogen glucosyltransferase activity", "positive regulation of UDPG-glycogen transglucosylase activity", "positive regulation of UDPG-glycogen synthetase activity", "positive regulation of glycogen (starch) synthetase activity", "positive regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "positive regulation of glycogen (starch) synthase activity", "definition": "Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity. [GOC:obol]"}
{"concept_id": "C3157711", "aliases": ["regulation of peroxidase reaction", "regulation of donor:hydrogen-peroxide oxidoreductase activity", "regulation of oxyperoxidase activity"], "types": ["T044"], "canonical_name": "regulation of peroxidase activity", "definition": "Any process that modulates the frequency, rate or extent of peroxidase activity. [GOC:obol]"}
{"concept_id": "C3157712", "aliases": ["negative regulation of donor:hydrogen-peroxide oxidoreductase activity", "negative regulation of oxyperoxidase activity", "negative regulation of peroxidase reaction"], "types": ["T044"], "canonical_name": "negative regulation of peroxidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity. [GOC:obol]"}
{"concept_id": "C3157713", "aliases": ["positive regulation of peroxidase reaction", "positive regulation of oxyperoxidase activity", "positive regulation of donor:hydrogen-peroxide oxidoreductase activity"], "types": ["T044"], "canonical_name": "positive regulation of peroxidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of peroxidase activity. [GOC:obol]"}
{"concept_id": "C3157714", "aliases": ["regulation of hemopoietic stem cell migration"], "types": ["T043"], "canonical_name": "regulation of hematopoietic stem cell migration", "definition": "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration. [GOC:obol]"}
{"concept_id": "C3157715", "aliases": ["negative regulation of hemopoietic stem cell migration"], "types": ["T043"], "canonical_name": "negative regulation of hematopoietic stem cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration. [GOC:obol]"}
{"concept_id": "C3157716", "aliases": ["positive regulation of hemopoietic stem cell migration"], "types": ["T043"], "canonical_name": "positive regulation of hematopoietic stem cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration. [GOC:obol]"}
{"concept_id": "C3157717", "aliases": ["regulation of opioid receptor signalling pathway"], "types": ["T043"], "canonical_name": "regulation of opioid receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway. [GOC:obol]"}
{"concept_id": "C3157718", "aliases": ["negative regulation of opioid receptor signalling pathway"], "types": ["T043"], "canonical_name": "negative regulation of opioid receptor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway. [GOC:obol]"}
{"concept_id": "C3157719", "aliases": ["positive regulation of opioid receptor signalling pathway"], "types": ["T043"], "canonical_name": "positive regulation of opioid receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of opioid receptor signaling pathway. [GOC:obol]"}
{"concept_id": "C3157720", "aliases": ["regulation of metanephric glomerular visceral epithelial cell development"], "types": ["T043"], "canonical_name": "regulation of metanephric podocyte development", "definition": "Any process that modulates the frequency, rate or extent of metanephric glomerular visceral epithelial cell development. [GOC:obol]"}
{"concept_id": "C3157722", "aliases": ["positive regulation of metanephric glomerular visceral epithelial cell development"], "types": ["T043"], "canonical_name": "positive regulation of metanephric podocyte development", "definition": "Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development. [GOC:obol]"}
{"concept_id": "C3157724", "aliases": ["regulation of cAMP-dependent protein kinase, intrinsic catalyst activity", "regulation of 3',5'-cAMP-dependent protein kinase activity", "regulation of 3',5' cAMP-dependent protein kinase activity", "regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity", "regulation of cyclic AMP-dependent protein kinase activity", "regulation of ATP:protein phosphotransferase (cAMP-dependent) activity"], "types": ["T043"], "canonical_name": "regulation of cAMP-dependent protein kinase activity", "definition": "Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity. [GOC:obol]"}
{"concept_id": "C3157725", "aliases": [], "types": ["T043"], "canonical_name": "regulation of AMPK"}
{"concept_id": "C3157726", "aliases": [], "types": ["T043"], "canonical_name": "regulation of PKA"}
{"concept_id": "C3157727", "aliases": [], "types": ["T043"], "canonical_name": "regulation of PKA C"}
{"concept_id": "C3157728", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein kinase A activity"}
{"concept_id": "C3157729", "aliases": [], "types": ["T043"], "canonical_name": "regulation of STK22"}
{"concept_id": "C3157730", "aliases": ["negative regulation of cyclic AMP-dependent protein kinase activity", "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity", "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity", "negative regulation of 3',5'-cAMP-dependent protein kinase activity", "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity", "negative regulation of 3',5' cAMP-dependent protein kinase activity"], "types": ["T043"], "canonical_name": "negative regulation of cAMP-dependent protein kinase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity. [GOC:obol]"}
{"concept_id": "C3157731", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of AMPK"}
{"concept_id": "C3157732", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of PKA"}
{"concept_id": "C3157733", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of PKA C"}
{"concept_id": "C3157734", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of protein kinase A activity"}
{"concept_id": "C3157735", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of STK22"}
{"concept_id": "C3157736", "aliases": ["positive regulation of 3',5' cAMP-dependent protein kinase activity", "positive regulation of cAMP-dependent protein kinase, intrinsic catalyst activity", "positive regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity", "positive regulation of ATP:protein phosphotransferase (cAMP-dependent) activity", "positive regulation of cyclic AMP-dependent protein kinase activity", "positive regulation of 3',5'-cAMP-dependent protein kinase activity"], "types": ["T043"], "canonical_name": "positive regulation of cAMP-dependent protein kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity. [GOC:obol]"}
{"concept_id": "C3157737", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of AMPK"}
{"concept_id": "C3157738", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of PKA"}
{"concept_id": "C3157739", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of PKA C"}
{"concept_id": "C3157740", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein kinase A activity"}
{"concept_id": "C3157741", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of STK22"}
{"concept_id": "C3157745", "aliases": [], "types": ["T044"], "canonical_name": "regulation of glutamine transport", "definition": "Any process that modulates the frequency, rate or extent of glutamine transport. [GOC:obol]"}
{"concept_id": "C3157746", "aliases": [], "types": ["T044"], "canonical_name": "regulation of L-glutamine transport"}
{"concept_id": "C3157747", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of glutamine transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glutamine transport. [GOC:obol]"}
{"concept_id": "C3157748", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of L-glutamine transport"}
{"concept_id": "C3157749", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of glutamine transport", "definition": "Any process that activates or increases the frequency, rate or extent of glutamine transport. [GOC:obol]"}
{"concept_id": "C3157750", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of L-glutamine transport"}
{"concept_id": "C3157751", "aliases": ["positive regulation of brassinosteroid anabolism", "positive regulation of brassinosteroid formation", "positive regulation of brassinosteroid synthesis", "positive regulation of brassinosteroid biosynthesis"], "types": ["T040"], "canonical_name": "positive regulation of brassinosteroid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of brassinosteroid biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157752", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hepatic stellate cell activation", "definition": "Any process that modulates the frequency, rate or extent of hepatic stellate cell activation. [GOC:obol]"}
{"concept_id": "C3157753", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of hepatic stellate cell activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation. [GOC:obol]"}
{"concept_id": "C3157754", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of hepatic stellate cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation. [GOC:obol]"}
{"concept_id": "C3157755", "aliases": ["regulation of interleukin-18-mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of interleukin-18-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of interleukin-18-mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3157756", "aliases": ["negative regulation of interleukin-18-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of interleukin-18-mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18-mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3157757", "aliases": ["positive regulation of interleukin-18-mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of interleukin-18-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-18-mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3157758", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in compound eye morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. [GOC:obol]"}
{"concept_id": "C3157759", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell proliferation involved in compound eye morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. [GOC:obol]"}
{"concept_id": "C3157760", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell proliferation involved in compound eye morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. [GOC:obol]"}
{"concept_id": "C3157764", "aliases": [], "types": ["T043"], "canonical_name": "regulation of natural killer cell chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis. [GOC:BHF]"}
{"concept_id": "C3157765", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis. [GOC:BHF]"}
{"concept_id": "C3157766", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis. [GOC:BHF]"}
{"concept_id": "C3157767", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of blood vessel remodeling", "definition": "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling. [GOC:obol]"}
{"concept_id": "C3157771", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendritic cell chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis. [GOC:obol]"}
{"concept_id": "C3157772", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of dendritic cell chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis. [GOC:obol]"}
{"concept_id": "C3157773", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of dendritic cell chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis. [GOC:obol]"}
{"concept_id": "C3157774", "aliases": [], "types": ["T038"], "canonical_name": "regulation of granzyme A production", "definition": "Any process that modulates the frequency, rate or extent of granzyme A production. [GOC:obol]"}
{"concept_id": "C3157775", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of granzyme A production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production. [GOC:obol]"}
{"concept_id": "C3157776", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of granzyme A production", "definition": "Any process that activates or increases the frequency, rate or extent of granzyme A production. [GOC:obol]"}
{"concept_id": "C3157777", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CD4-positive, alpha-beta T cell activation", "definition": "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. [GOC:obol]"}
{"concept_id": "C3157778", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CD4-positive, alpha-beta T cell activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. [GOC:obol]"}
{"concept_id": "C3157779", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CD4-positive, alpha-beta T cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. [GOC:obol]"}
{"concept_id": "C3157780", "aliases": ["regulation of Th1 cell activation"], "types": ["T043"], "canonical_name": "regulation of T-helper 1 cell activation", "definition": "Any process that modulates the frequency, rate or extent of T-helper 1 cell activation. [GOC:obol]"}
{"concept_id": "C3157781", "aliases": ["negative regulation of Th1 cell activation"], "types": ["T043"], "canonical_name": "negative regulation of T-helper 1 cell activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation. [GOC:obol]"}
{"concept_id": "C3157782", "aliases": ["positive regulation of Th1 cell activation"], "types": ["T043"], "canonical_name": "positive regulation of T-helper 1 cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell activation. [GOC:obol]"}
{"concept_id": "C3157783", "aliases": ["regulation of formation of immunological synapse"], "types": ["T038"], "canonical_name": "regulation of immunological synapse formation", "definition": "Any process that modulates the frequency, rate or extent of immunological synapse formation. [GOC:obol]"}
{"concept_id": "C3157784", "aliases": ["negative regulation of formation of immunological synapse"], "types": ["T043"], "canonical_name": "negative regulation of immunological synapse formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation. [GOC:obol]"}
{"concept_id": "C3157785", "aliases": ["positive regulation of formation of immunological synapse"], "types": ["T043"], "canonical_name": "positive regulation of immunological synapse formation", "definition": "Any process that activates or increases the frequency, rate or extent of immunological synapse formation. [GOC:obol]"}
{"concept_id": "C3157786", "aliases": ["regulation of T cell co-stimulation", "regulation of T-lymphocyte costimulation", "regulation of T lymphocyte costimulation", "regulation of T-cell costimulation", "regulation of T-cell co-stimulation"], "types": ["T038"], "canonical_name": "regulation of T cell costimulation", "definition": "Any process that modulates the frequency, rate or extent of T cell costimulation. [GOC:obol]"}
{"concept_id": "C3157787", "aliases": ["negative regulation of T-cell costimulation", "negative regulation of T-cell co-stimulation", "negative regulation of T lymphocyte costimulation", "negative regulation of T-lymphocyte costimulation", "negative regulation of T cell co-stimulation"], "types": ["T038"], "canonical_name": "negative regulation of T cell costimulation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T cell costimulation. [GOC:obol]"}
{"concept_id": "C3157788", "aliases": ["positive regulation of T cell co-stimulation", "positive regulation of T-cell costimulation", "positive regulation of T lymphocyte costimulation", "positive regulation of T-lymphocyte costimulation", "positive regulation of T-cell co-stimulation"], "types": ["T038"], "canonical_name": "positive regulation of T cell costimulation", "definition": "Any process that activates or increases the frequency, rate or extent of T cell costimulation. [GOC:obol]"}
{"concept_id": "C3157789", "aliases": ["positive regulation of glycoprotein biosynthetic process of formation of immunological synapse", "positive regulation of glycoprotein biosynthetic process of immunological synapse formation"], "types": ["T040"], "canonical_name": "positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation", "definition": "Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation. [GOC:obol]"}
{"concept_id": "C3157790", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myeloid dendritic cell chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis. [GOC:obol]"}
{"concept_id": "C3157791", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myeloid dendritic cell chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis. [GOC:obol]"}
{"concept_id": "C3157792", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of myeloid dendritic cell chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis. [GOC:obol]"}
{"concept_id": "C3157795", "aliases": [], "types": ["T038"], "canonical_name": "regulation of renal albumin absorption", "definition": "Any process that modulates the frequency, rate or extent of renal albumin absorption. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157796", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of renal albumin absorption", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157797", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of renal albumin absorption", "definition": "Any process that activates or increases the frequency, rate or extent of renal albumin absorption. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157798", "aliases": ["regulation of bacterial entry into host cell", "regulation of invasion of bacteria into host cell"], "types": ["T040"], "canonical_name": "regulation of entry of bacterium into host cell", "definition": "Any process that modulates the frequency, rate or extent of entry of bacterium into host cell. [GOC:obol]"}
{"concept_id": "C3157799", "aliases": ["negative regulation of invasion of bacteria into host cell", "negative regulation of bacterial entry into host cell"], "types": ["T040"], "canonical_name": "negative regulation of entry of bacterium into host cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell. [GOC:obol]"}
{"concept_id": "C3157800", "aliases": [], "types": ["T043"], "canonical_name": "regulation of B cell chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of B cell chemotaxis. [GOC:obol]"}
{"concept_id": "C3157801", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of B cell chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of B cell chemotaxis. [GOC:obol]"}
{"concept_id": "C3157802", "aliases": ["regulation of protein amino acid geranylgeranylation"], "types": ["T044"], "canonical_name": "regulation of protein geranylgeranylation", "definition": "Any process that modulates the frequency, rate or extent of protein geranylgeranylation. [GOC:obol]"}
{"concept_id": "C3157803", "aliases": [], "types": ["T044"], "canonical_name": "regulation of C-terminal protein geranylgeranylation"}
{"concept_id": "C3157804", "aliases": ["negative regulation of protein amino acid geranylgeranylation"], "types": ["T044"], "canonical_name": "negative regulation of protein geranylgeranylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation. [GOC:obol]"}
{"concept_id": "C3157805", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of C-terminal protein geranylgeranylation"}
{"concept_id": "C3157806", "aliases": ["positive regulation of protein amino acid geranylgeranylation"], "types": ["T044"], "canonical_name": "positive regulation of protein geranylgeranylation", "definition": "Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation. [GOC:obol]"}
{"concept_id": "C3157807", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of C-terminal protein geranylgeranylation"}
{"concept_id": "C3157808", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of gastrulation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. [GOC:obol]"}
{"concept_id": "C3157809", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of gastrulation", "definition": "Any process that activates or increases the frequency, rate or extent of gastrulation. [GOC:obol]"}
{"concept_id": "C3157810", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelial cell chemotaxis to fibroblast growth factor", "definition": "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor. [GOC:obol]"}
{"concept_id": "C3157811", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell chemotaxis to fibroblast growth factor", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor. [GOC:obol]"}
{"concept_id": "C3157812", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endothelial cell chemotaxis to fibroblast growth factor", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor. [GOC:obol]"}
{"concept_id": "C3157813", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendritic cell dendrite assembly", "definition": "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly. [GOC:obol]"}
{"concept_id": "C3157814", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendritic extension"}
{"concept_id": "C3157815", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of dendritic cell dendrite assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly. [GOC:obol]"}
{"concept_id": "C3157816", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of dendritic extension"}
{"concept_id": "C3157817", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of dendritic cell dendrite assembly", "definition": "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly. [GOC:obol]"}
{"concept_id": "C3157818", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of dendritic extension"}
{"concept_id": "C3157819", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of B cell chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis. [GOC:obol]"}
{"concept_id": "C3157820", "aliases": ["regulation of Th2 cell cytokine production"], "types": ["T043"], "canonical_name": "regulation of T-helper 2 cell cytokine production", "definition": "Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production. [GOC:obol]"}
{"concept_id": "C3157821", "aliases": ["negative regulation of Th2 cell cytokine production"], "types": ["T043"], "canonical_name": "negative regulation of T-helper 2 cell cytokine production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production. [GOC:obol]"}
{"concept_id": "C3157822", "aliases": ["positive regulation of Th2 cell cytokine production"], "types": ["T043"], "canonical_name": "positive regulation of T-helper 2 cell cytokine production", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production. [GOC:obol]"}
{"concept_id": "C3157823", "aliases": ["regulation of Th1 cell cytokine production"], "types": ["T043"], "canonical_name": "regulation of T-helper 1 cell cytokine production", "definition": "Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production. [GOC:obol]"}
{"concept_id": "C3157824", "aliases": ["negative regulation of Th1 cell cytokine production"], "types": ["T043"], "canonical_name": "negative regulation of T-helper 1 cell cytokine production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production. [GOC:obol]"}
{"concept_id": "C3157825", "aliases": ["positive regulation of Th1 cell cytokine production"], "types": ["T043"], "canonical_name": "positive regulation of T-helper 1 cell cytokine production", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production. [GOC:obol]"}
{"concept_id": "C3157826", "aliases": ["regulation of antibody production in mucosal tissue"], "types": ["T043"], "canonical_name": "regulation of immunoglobulin production in mucosal tissue", "definition": "Any process that modulates the frequency, rate or extent of immunoglobulin production in mucosal tissue. [GOC:obol]"}
{"concept_id": "C3157827", "aliases": ["positive regulation of antibody production in mucosal tissue"], "types": ["T043"], "canonical_name": "positive regulation of immunoglobulin production in mucosal tissue", "definition": "Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue. [GOC:obol]"}
{"concept_id": "C3157828", "aliases": ["regulation of CD24 synthesis", "regulation of CD24 biosynthesis", "regulation of CD24 formation", "regulation of CD24 anabolism", "regulation of CD24 biosynthetic process"], "types": ["T040"], "canonical_name": "regulation of CD24 production", "definition": "Any process that modulates the frequency, rate or extent of CD24 biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157829", "aliases": ["positive regulation of CD24 anabolism", "positive regulation of CD24 biosynthetic process", "positive regulation of CD24 synthesis", "positive regulation of CD24 biosynthesis", "positive regulation of CD24 formation"], "types": ["T040"], "canonical_name": "positive regulation of CD24 production", "definition": "Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157830", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CD4-positive, alpha-beta T cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol]"}
{"concept_id": "C3157831", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CD4-positive, alpha-beta T cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol]"}
{"concept_id": "C3157832", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CD4-positive, alpha-beta T cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol]"}
{"concept_id": "C3157833", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CD8-positive, alpha-beta T cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. [GOC:obol]"}
{"concept_id": "C3157834", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CD8-positive, alpha-beta T cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. [GOC:obol]"}
{"concept_id": "C3157835", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CD8-positive, alpha-beta T cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. [GOC:obol]"}
{"concept_id": "C3157836", "aliases": [], "types": ["T043"], "canonical_name": "regulation of memory T cell activation", "definition": "Any process that modulates the frequency, rate or extent of memory T cell activation. [GOC:obol]"}
{"concept_id": "C3157837", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of memory T cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of memory T cell activation. [GOC:obol]"}
{"concept_id": "C3157838", "aliases": ["regulation of Th2 cell activation"], "types": ["T043"], "canonical_name": "regulation of T-helper 2 cell activation", "definition": "Any process that modulates the frequency, rate or extent of T-helper 2 cell activation. [GOC:obol]"}
{"concept_id": "C3157839", "aliases": ["positive regulation of Th2 cell activation"], "types": ["T043"], "canonical_name": "positive regulation of T-helper 2 cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation. [GOC:obol]"}
{"concept_id": "C3157840", "aliases": ["regulation of IL-4-dependent isotype switching to IgE isotypes"], "types": ["T043"], "canonical_name": "regulation of interleukin-4-dependent isotype switching to IgE isotypes", "definition": "Any process that modulates the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes. [GOC:obol]"}
{"concept_id": "C3157841", "aliases": ["positive regulation of IL-4-dependent isotype switching to IgE isotypes"], "types": ["T043"], "canonical_name": "positive regulation of interleukin-4-dependent isotype switching to IgE isotypes", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes. [GOC:obol]"}
{"concept_id": "C3157842", "aliases": ["positive regulation of DNA formation", "positive regulation of DNA synthesis", "positive regulation of DNA biosynthesis", "positive regulation of DNA anabolism"], "types": ["T044"], "canonical_name": "positive regulation of DNA biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. [GOC:obol]"}
{"concept_id": "C3157879", "aliases": ["regulation of PDGF receptor-alpha signaling pathway", "regulation of platelet-derived growth factor receptor-alpha signalling pathway", "regulation of alphaPDGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of platelet-derived growth factor receptor-alpha signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway. [GOC:obol]"}
{"concept_id": "C3157880", "aliases": [], "types": ["T044"], "canonical_name": "regulation of PDGFR-alpha signaling pathway"}
{"concept_id": "C3157881", "aliases": ["negative regulation of platelet-derived growth factor receptor-alpha signalling pathway", "negative regulation of PDGF receptor-alpha signaling pathway", "negative regulation of PDGFR-alpha signaling pathway", "negative regulation of alphaPDGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of platelet-derived growth factor receptor-alpha signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway. [GOC:obol, GOC:yaf]"}
{"concept_id": "C3157883", "aliases": ["positive regulation of PDGF receptor-alpha signaling pathway", "positive regulation of platelet-derived growth factor receptor-alpha signalling pathway", "positive regulation of alphaPDGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of platelet-derived growth factor receptor-alpha signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway. [GOC:obol]"}
{"concept_id": "C3157884", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of PDGFR-alpha signaling pathway"}
{"concept_id": "C3157885", "aliases": ["regulation of platelet-derived growth factor receptor-beta signalling pathway", "regulation of PDGF receptor-beta signaling pathway", "regulation of betaPDGF receptor signaling pathway", "regulation of PDGFR-beta signaling pathway"], "types": ["T044"], "canonical_name": "regulation of platelet-derived growth factor receptor-beta signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. [GOC:obol]"}
{"concept_id": "C3157886", "aliases": ["negative regulation of betaPDGF receptor signaling pathway", "negative regulation of platelet-derived growth factor receptor-beta signalling pathway", "negative regulation of PDGFR-beta signaling pathway", "negative regulation of PDGF receptor-beta signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of platelet-derived growth factor receptor-beta signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. [GOC:obol]"}
{"concept_id": "C3157887", "aliases": ["positive regulation of PDGF receptor-beta signaling pathway", "positive regulation of betaPDGF receptor signaling pathway", "positive regulation of platelet-derived growth factor receptor-beta signalling pathway", "positive regulation of PDGFR-beta signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of platelet-derived growth factor receptor-beta signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. [GOC:obol]"}
{"concept_id": "C3157888", "aliases": [], "types": ["T043"], "canonical_name": "regulation of metanephric mesenchymal cell migration", "definition": "Any process that modulates the frequency, rate or extent of metanephric mesenchymal cell migration. [GOC:obol]"}
{"concept_id": "C3157889", "aliases": [], "types": ["T043"], "canonical_name": "regulation of metanephric mesenchyme chemotaxis"}
{"concept_id": "C3157890", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of metanephric mesenchymal cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration. [GOC:obol]"}
{"concept_id": "C3157891", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of metanephric mesenchyme chemotaxis"}
{"concept_id": "C3157892", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of metanephric mesenchymal cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of metanephric mesenchymal cell migration. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3157893", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of metanephric mesenchyme chemotaxis"}
{"concept_id": "C3157894", "aliases": ["regulation of metanephric distal convoluted tubule cell differentiation"], "types": ["T043"], "canonical_name": "regulation of metanephric DCT cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of metanephric DCT cell differentiation. [GOC:obol]"}
{"concept_id": "C3157895", "aliases": ["negative regulation of metanephric distal convoluted tubule cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of metanephric DCT cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric DCT cell differentiation. [GOC:obol]"}
{"concept_id": "C3157896", "aliases": ["positive regulation of metanephric distal convoluted tubule cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of metanephric DCT cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation. [GOC:obol]"}
{"concept_id": "C3157897", "aliases": [], "types": ["T038"], "canonical_name": "regulation of optic nerve formation", "definition": "Any process that modulates the frequency, rate or extent of optic nerve formation. [GOC:obol]"}
{"concept_id": "C3157898", "aliases": [], "types": ["T038"], "canonical_name": "regulation of CN II biosynthesis"}
{"concept_id": "C3157899", "aliases": [], "types": ["T038"], "canonical_name": "regulation of CN II formation"}
{"concept_id": "C3157900", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of optic nerve formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of optic nerve formation. [GOC:obol]"}
{"concept_id": "C3157901", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of CN II biosynthesis"}
{"concept_id": "C3157902", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of CN II formation"}
{"concept_id": "C3157903", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of optic nerve formation", "definition": "Any process that activates or increases the frequency, rate or extent of optic nerve formation. [GOC:obol]"}
{"concept_id": "C3157904", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of CN II biosynthesis"}
{"concept_id": "C3157905", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of CN II formation"}
{"concept_id": "C3157909", "aliases": ["positive regulation of branched actin filament nucleation", "positive regulation of actin filament branch nucleation"], "types": ["T040"], "canonical_name": "positive regulation of Arp2/3 complex-mediated actin nucleation", "definition": "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation. [PMID:21454476]"}
{"concept_id": "C3157911", "aliases": [], "types": ["T040"], "canonical_name": "regulation of secondary growth", "definition": "Any process that modulates the frequency, rate or extent of secondary growth. [GOC:obol]"}
{"concept_id": "C3157912", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of secondary growth", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of secondary growth. [GOC:obol]"}
{"concept_id": "C3157913", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of secondary growth", "definition": "Any process that activates or increases the frequency, rate or extent of secondary growth. [GOC:obol]"}
{"concept_id": "C3157914", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in mesonephros development", "definition": "Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development. [GOC:obol]"}
{"concept_id": "C3157915", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell proliferation involved in mesonephros development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development. [GOC:obol]"}
{"concept_id": "C3157916", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell proliferation involved in mesonephros development", "definition": "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development. [GOC:obol]"}
{"concept_id": "C3157917", "aliases": [], "types": ["T044"], "canonical_name": "regulation of thyroid hormone generation", "definition": "Any process that modulates the frequency, rate or extent of thyroid hormone generation. [GOC:obol]"}
{"concept_id": "C3157918", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of thyroid hormone generation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation. [GOC:obol]"}
{"concept_id": "C3157919", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of thyroid hormone generation", "definition": "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation. [GOC:obol]"}
{"concept_id": "C3157920", "aliases": ["regulation of TSH secretion", "regulation of thyroid stimulating hormone secretion"], "types": ["T043"], "canonical_name": "regulation of thyroid-stimulating hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion. [GOC:obol]"}
{"concept_id": "C3157921", "aliases": ["negative regulation of thyroid stimulating hormone secretion", "negative regulation of TSH secretion"], "types": ["T043"], "canonical_name": "negative regulation of thyroid-stimulating hormone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion. [GOC:obol]"}
{"concept_id": "C3157922", "aliases": ["positive regulation of TSH secretion", "positive regulation of thyroid stimulating hormone secretion"], "types": ["T043"], "canonical_name": "positive regulation of thyroid-stimulating hormone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion. [GOC:obol]"}
{"concept_id": "C3157923", "aliases": ["regulation of histone H3 acetylation at K9", "regulation of histone H3K9 acetylation"], "types": ["T045"], "canonical_name": "regulation of histone H3-K9 acetylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation. [GOC:BHF]"}
{"concept_id": "C3157924", "aliases": ["negative regulation of histone H3K9 acetylation", "negative regulation of histone H3 acetylation at K9"], "types": ["T045"], "canonical_name": "negative regulation of histone H3-K9 acetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation. [GOC:BHF]"}
{"concept_id": "C3157925", "aliases": ["positive regulation of histone H3K9 acetylation", "positive regulation of histone H3 acetylation at K9"], "types": ["T045"], "canonical_name": "positive regulation of histone H3-K9 acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation. [GOC:BHF]"}
{"concept_id": "C3157926", "aliases": ["regulation of histone H4 acetylation at K16"], "types": ["T043"], "canonical_name": "regulation of histone H4-K16 acetylation", "definition": "Any process that modulates the frequency, rate or extent of histone H4-K16 acetylation. [GOC:BHF]"}
{"concept_id": "C3157927", "aliases": ["negative regulation of histone H4 acetylation at K16"], "types": ["T045"], "canonical_name": "negative regulation of histone H4-K16 acetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation. [GOC:BHF]"}
{"concept_id": "C3157928", "aliases": ["positive regulation of histone H4 acetylation at K16"], "types": ["T043"], "canonical_name": "positive regulation of histone H4-K16 acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation. [GOC:BHF]"}
{"concept_id": "C3157929", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA replication termination", "definition": "Any process that modulates the frequency, rate or extent of DNA replication termination. [GOC:obol]"}
{"concept_id": "C3157930", "aliases": ["regulation of nuclear mRNA catabolic process, nonsense-mediated decay", "regulation of mRNA catabolic process, nonsense-mediated", "regulation of mRNA catabolism, nonsense-mediated", "regulation of mRNA degradation, nonsense-mediated decay", "regulation of nonsense-mediated mRNA decay", "regulation of mRNA breakdown, nonsense-mediated decay"], "types": ["T044"], "canonical_name": "regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "definition": "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. [GOC:obol]"}
{"concept_id": "C3157931", "aliases": ["negative regulation of nonsense-mediated mRNA decay", "negative regulation of mRNA degradation, nonsense-mediated decay", "negative regulation of mRNA catabolism, nonsense-mediated", "negative regulation of mRNA breakdown, nonsense-mediated decay", "negative regulation of nuclear mRNA catabolic process, nonsense-mediated decay", "negative regulation of mRNA catabolic process, nonsense-mediated"], "types": ["T044"], "canonical_name": "negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. [GOC:obol]"}
{"concept_id": "C3157932", "aliases": ["positive regulation of mRNA catabolic process, nonsense-mediated", "positive regulation of mRNA breakdown, nonsense-mediated decay", "positive regulation of nuclear mRNA catabolic process, nonsense-mediated decay", "positive regulation of mRNA degradation, nonsense-mediated decay", "positive regulation of nonsense-mediated mRNA decay", "positive regulation of mRNA catabolism, nonsense-mediated"], "types": ["T044"], "canonical_name": "positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "definition": "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. [GOC:obol]"}
{"concept_id": "C3157933", "aliases": ["regulation of microRNA catabolic process"], "types": ["T044"], "canonical_name": "regulation of miRNA catabolic process", "definition": "Any process that modulates the frequency, rate or extent of miRNA catabolic process. [GOC:dph]"}
{"concept_id": "C3157934", "aliases": ["negative regulation of microRNA catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of miRNA catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process. [GOC:dph]"}
{"concept_id": "C3157935", "aliases": ["positive regulation of microRNA catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of miRNA catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of miRNA catabolic process. [GOC:dph]"}
{"concept_id": "C3157936", "aliases": ["regulation of microRNA metabolic process"], "types": ["T045"], "canonical_name": "regulation of miRNA metabolic process", "definition": "Any process that modulates the frequency, rate or extent of miRNA metabolic process. [GOC:dph]"}
{"concept_id": "C3157937", "aliases": ["negative regulation of microRNA metabolic process"], "types": ["T045"], "canonical_name": "negative regulation of miRNA metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process. [GOC:dph]"}
{"concept_id": "C3157938", "aliases": ["positive regulation of microRNA metabolic process"], "types": ["T045"], "canonical_name": "positive regulation of miRNA metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process. [GOC:dph]"}
{"concept_id": "C3157939", "aliases": ["regulation of pre-microRNA processing"], "types": ["T045"], "canonical_name": "regulation of pre-miRNA processing", "definition": "Any process that modulates the frequency, rate or extent of pre-microRNA processing. [GOC:dph, GOC:sl]"}
{"concept_id": "C3157940", "aliases": ["negative regulation of pre-microRNA processing"], "types": ["T045"], "canonical_name": "negative regulation of pre-miRNA processing", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing. [GOC:dph, GOC:sl]"}
{"concept_id": "C3157941", "aliases": ["positive regulation of pre-microRNA processing"], "types": ["T045"], "canonical_name": "positive regulation of pre-miRNA processing", "definition": "Any process that activates or increases the frequency, rate or extent of pre-microRNA processing. [GOC:dph, GOC:sl]"}
{"concept_id": "C3157942", "aliases": ["regulation of pri-miRNA processing", "regulation of primary microRNA processing"], "types": ["T045"], "canonical_name": "regulation of primary miRNA processing", "definition": "Any process that modulates the frequency, rate or extent of primary microRNA processing. [GOC:dph, GOC:sl]"}
{"concept_id": "C3157943", "aliases": ["negative regulation of primary microRNA processing", "negative regulation of pri-miRNA processing"], "types": ["T045"], "canonical_name": "negative regulation of primary miRNA processing", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing. [GOC:dph, GOC:sl]"}
{"concept_id": "C3157944", "aliases": ["positive regulation of pri-miRNA processing", "positive regulation of primary microRNA processing"], "types": ["T045"], "canonical_name": "positive regulation of primary miRNA processing", "definition": "Any process that activates or increases the frequency, rate or extent of primary microRNA processing. [GOC:dph, GOC:sl]"}
{"concept_id": "C3157945", "aliases": ["positive regulation of microRNA-mediated gene silencing", "positive regulation of gene silencing by miRNA"], "types": ["T045"], "canonical_name": "positive regulation of miRNA-mediated gene silencing", "definition": "A process that activates or increases the frequency, rate or extent of gene silencing by a microRNA (miRNA). [GOC:dph]"}
{"concept_id": "C3157946", "aliases": ["regulation of SREBP-mediated signaling pathway", "regulation of SREBP-mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of SREBP signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the SREBP signaling pathway. [GOC:BHF]"}
{"concept_id": "C3157947", "aliases": ["negative regulation of SREBP-mediated signaling pathway", "negative regulation of SREBP-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of SREBP signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway. [GOC:BHF]"}
{"concept_id": "C3157948", "aliases": ["positive regulation of SREBP-mediated signalling pathway", "positive regulation of SREBP-mediated signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of SREBP signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway. [GOC:BHF]"}
{"concept_id": "C3157949", "aliases": [], "types": ["T043"], "canonical_name": "regulation of early endosome to late endosome transport", "definition": "Any process that modulates the frequency, rate or extent of early endosome to late endosome transport. [GOC:BHF]"}
{"concept_id": "C3157950", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of early endosome to late endosome transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport. [GOC:BHF]"}
{"concept_id": "C3157951", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of early endosome to late endosome transport", "definition": "Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport. [GOC:BHF]"}
{"concept_id": "C3157952", "aliases": ["regulation of receptor breakdown", "regulation of receptor degradation", "regulation of receptor catabolism"], "types": ["T044"], "canonical_name": "regulation of receptor catabolic process", "definition": "Any process that modulates the frequency, rate or extent of receptor catabolic process. [GOC:BHF]"}
{"concept_id": "C3157953", "aliases": ["negative regulation of receptor degradation", "negative regulation of receptor catabolism", "negative regulation of receptor breakdown"], "types": ["T044"], "canonical_name": "negative regulation of receptor catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process. [GOC:BHF]"}
{"concept_id": "C3157954", "aliases": ["positive regulation of receptor catabolism", "positive regulation of receptor breakdown", "positive regulation of receptor degradation"], "types": ["T044"], "canonical_name": "positive regulation of receptor catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of receptor catabolic process. [GOC:BHF]"}
{"concept_id": "C3157955", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of stem cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. [GOC:dph]"}
{"concept_id": "C3157956", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of stem cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of stem cell proliferation. [GOC:dph]"}
{"concept_id": "C3157957", "aliases": ["regulation of sodium transporter activity"], "types": ["T043"], "canonical_name": "regulation of sodium ion transmembrane transporter activity", "definition": "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. [GOC:obol]"}
{"concept_id": "C3157958", "aliases": ["negative regulation of sodium transporter activity"], "types": ["T038"], "canonical_name": "negative regulation of sodium ion transmembrane transporter activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. [GOC:obol]"}
{"concept_id": "C3157959", "aliases": ["positive regulation of sodium transporter activity"], "types": ["T038"], "canonical_name": "positive regulation of sodium ion transmembrane transporter activity", "definition": "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. [GOC:obol]"}
{"concept_id": "C3157960", "aliases": ["regulation of cellulose and pectin-containing secondary cell wall biogenesis", "regulation of plant-type secondary cell wall biogenesis"], "types": ["T043"], "canonical_name": "regulation of secondary cell wall biogenesis", "definition": "Any process that modulates the frequency, rate or extent of secondary cell wall biogenesis. [GOC:obol]"}
{"concept_id": "C3157961", "aliases": [], "types": ["T043"], "canonical_name": "regulation of secondary cell wall anabolism"}
{"concept_id": "C3157962", "aliases": ["regulation of secondary cell wall formation", "regulation of secondary cell wall synthesis"], "types": ["T043"], "canonical_name": "regulation of secondary cell wall biosynthetic process"}
{"concept_id": "C3157963", "aliases": ["regulation of DNA imprinting"], "types": ["T043"], "canonical_name": "regulation of genetic imprinting", "definition": "Any process that modulates the frequency, rate or extent of genetic imprinting. [GOC:BHF]"}
{"concept_id": "C3157964", "aliases": [], "types": ["T039"], "canonical_name": "regulation of cellular response to testosterone stimulus", "definition": "Any process that modulates the frequency, rate or extent of cellular response to testosterone stimulus. [GOC:BHF]"}
{"concept_id": "C3157965", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular response to testosterone stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus. [GOC:BHF]"}
{"concept_id": "C3157966", "aliases": [], "types": ["T044"], "canonical_name": "regulation of apolipoprotein binding", "definition": "Any process that modulates the frequency, rate or extent of apolipoprotein binding. [GOC:BHF]"}
{"concept_id": "C3157967", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of apolipoprotein binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding. [GOC:BHF]"}
{"concept_id": "C3157968", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of apolipoprotein binding", "definition": "Any process that activates or increases the frequency, rate or extent of apolipoprotein binding. [GOC:BHF]"}
{"concept_id": "C3157969", "aliases": ["regulation of interleukin-1-mediated signalling pathway", "regulation of IL-1-mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of interleukin-1-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3157970", "aliases": [], "types": ["T044"], "canonical_name": "regulation of IL-1 alpha-mediated signaling pathway"}
{"concept_id": "C3157971", "aliases": [], "types": ["T044"], "canonical_name": "regulation of IL-1 beta-mediated signaling pathway"}
{"concept_id": "C3157972", "aliases": [], "types": ["T044"], "canonical_name": "regulation of interleukin-1 alpha-mediated signaling pathway"}
{"concept_id": "C3157973", "aliases": [], "types": ["T044"], "canonical_name": "regulation of interleukin-1 beta-mediated signaling pathway"}
{"concept_id": "C3157974", "aliases": ["negative regulation of IL-1-mediated signaling pathway", "negative regulation of interleukin-1-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of interleukin-1-mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3157975", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of IL-1 alpha-mediated signaling pathway"}
{"concept_id": "C3157976", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of IL-1 beta-mediated signaling pathway"}
{"concept_id": "C3157977", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of interleukin-1 alpha-mediated signaling pathway"}
{"concept_id": "C3157978", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of interleukin-1 beta-mediated signaling pathway"}
{"concept_id": "C3157979", "aliases": ["positive regulation of interleukin-1-mediated signalling pathway", "positive regulation of IL-1-mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of interleukin-1-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3157980", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of IL-1 alpha-mediated signaling pathway"}
{"concept_id": "C3157981", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of IL-1 beta-mediated signaling pathway"}
{"concept_id": "C3157982", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of interleukin-1 alpha-mediated signaling pathway"}
{"concept_id": "C3157983", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of interleukin-1 beta-mediated signaling pathway"}
{"concept_id": "C3157990", "aliases": ["regulation of dendritic cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of dendritic cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3157991", "aliases": ["negative regulation of dendritic cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of dendritic cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3157992", "aliases": ["positive regulation of dendritic cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of dendritic cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3157993", "aliases": ["regulation of motor neuron apoptosis", "regulation of motoneuron apoptosis"], "types": ["T043"], "canonical_name": "regulation of motor neuron apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3157994", "aliases": ["negative regulation of motoneuron apoptosis", "negative regulation of motor neuron apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of motor neuron apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3157995", "aliases": ["positive regulation of motoneuron apoptosis", "positive regulation of motor neuron apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of motor neuron apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3157996", "aliases": ["regulation of pancreatic beta cell apoptosis", "regulation of type B pancreatic cell apoptosis", "regulation of pancreatic B cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of type B pancreatic cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3157997", "aliases": ["negative regulation of type B pancreatic cell apoptosis", "negative regulation of pancreatic beta cell apoptosis", "negative regulation of pancreatic B cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of type B pancreatic cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3157998", "aliases": ["positive regulation of pancreatic beta cell apoptosis", "positive regulation of type B pancreatic cell apoptosis", "positive regulation of pancreatic B cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of type B pancreatic cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3157999", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription regulatory region DNA binding", "definition": "Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding. [GOC:obol]"}
{"concept_id": "C3158000", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of transcription regulatory region DNA binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding. [GOC:obol]"}
{"concept_id": "C3158001", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of transcription regulatory region DNA binding", "definition": "Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. [GOC:obol]"}
{"concept_id": "C3158005", "aliases": ["regulation of cellular response to X-ray radiation stimulus"], "types": ["T039"], "canonical_name": "regulation of cellular response to X-ray", "definition": "Any process that modulates the frequency, rate or extent of cellular response to X-ray. [GOC:obol]"}
{"concept_id": "C3158006", "aliases": ["negative regulation of cellular response to X-ray radiation stimulus"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to X-ray", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray. [GOC:obol]"}
{"concept_id": "C3158007", "aliases": ["positive regulation of cellular response to X-ray radiation stimulus"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to X-ray", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to X-ray. [GOC:obol]"}
{"concept_id": "C3158014", "aliases": ["actin filament organization of cytokinesis, actomyosin contractile ring assembly", "actin filament organization of contractile ring assembly", "actin filament organization involved in cytokinetic actomyosin contractile ring assembly", "actin filament organisation of contractile ring assembly", "actin filament organisation of cytokinesis, actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "actomyosin contractile ring assembly actin filament organization", "definition": "An actin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis. [GOC:mah]"}
{"concept_id": "C3158015", "aliases": ["actin filament organization of constriction ring assembly"], "types": ["T043"], "canonical_name": "actin filament organisation of constriction ring assembly"}
{"concept_id": "C3158016", "aliases": ["actin filament organization of cytokinesis, actomyosin contractile ring formation"], "types": ["T043"], "canonical_name": "actin filament organisation of cytokinesis, actomyosin contractile ring formation"}
{"concept_id": "C3158017", "aliases": ["actin filament organization of cytokinesis, actomyosin ring biosynthesis"], "types": ["T043"], "canonical_name": "actin filament organisation of cytokinesis, actomyosin ring biosynthesis"}
{"concept_id": "C3158018", "aliases": ["actin filament organization of cytokinesis, actomyosin ring formation"], "types": ["T043"], "canonical_name": "actin filament organisation of cytokinesis, actomyosin ring formation"}
{"concept_id": "C3158019", "aliases": ["actin filament organization of cytokinesis, contractile ring assembly"], "types": ["T043"], "canonical_name": "actin filament organisation of cytokinesis, contractile ring assembly"}
{"concept_id": "C3158020", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament localization of constriction ring assembly"}
{"concept_id": "C3158021", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament localization of contractile ring assembly"}
{"concept_id": "C3158022", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly"}
{"concept_id": "C3158023", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation"}
{"concept_id": "C3158024", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis"}
{"concept_id": "C3158025", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament localization of cytokinesis, actomyosin ring formation"}
{"concept_id": "C3158026", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament localization of cytokinesis, contractile ring assembly"}
{"concept_id": "C3158027", "aliases": ["regulation of myocardial precursor cell differentiation"], "types": ["T043"], "canonical_name": "regulation of cardiac muscle cell myoblast differentiation", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation. [GOC:obol]"}
{"concept_id": "C3158028", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardiac myoblast differentiation"}
{"concept_id": "C3158029", "aliases": ["negative regulation of myocardial precursor cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of cardiac muscle cell myoblast differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation. [GOC:obol]"}
{"concept_id": "C3158030", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cardiac myoblast differentiation"}
{"concept_id": "C3158031", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of seed maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of seed maturation. [GOC:obol]"}
{"concept_id": "C3158032", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of seed maturation", "definition": "Any process that activates or increases the frequency, rate or extent of seed maturation. [GOC:obol]"}
{"concept_id": "C3158033", "aliases": ["regulation of phragmoplast microtubule organisation", "regulation of phragmoplast microtubule cytoskeleton organization"], "types": ["T043"], "canonical_name": "regulation of phragmoplast microtubule organization", "definition": "Any process that modulates the frequency, rate or extent of phragmoplast microtubule organization. [GOC:obol]"}
{"concept_id": "C3158038", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial cell differentiation involved in kidney development", "definition": "Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. [GOC:mtg_kidney_jan10, GOC:yaf]"}
{"concept_id": "C3158039", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of epithelial cell differentiation involved in kidney development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development. [GOC:mtg_kidney_jan10, GOC:yaf]"}
{"concept_id": "C3158040", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of epithelial cell differentiation involved in kidney development", "definition": "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development. [GOC:mtg_kidney_jan10, GOC:yaf]"}
{"concept_id": "C3158041", "aliases": ["FGF receptor signaling pathway of ureteric bud formation", "fibroblast growth factor receptor signaling pathway of ureteric bud formation", "fibroblast growth factor receptor signalling pathway of ureteric bud formation", "FGFR signaling pathway of ureteric bud formation", "FGF receptor signalling pathway of ureteric bud formation"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in ureteric bud formation", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct. [GOC:mtg_kidney_jan10, GOC:yaf]"}
{"concept_id": "C3158042", "aliases": ["positive regulation of myocardial precursor cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of cardiac muscle cell myoblast differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. [GOC:obol]"}
{"concept_id": "C3158043", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cardiac myoblast differentiation"}
{"concept_id": "C3158044", "aliases": ["glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation", "GDNF receptor signaling pathway of ureteric bud formation", "glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation", "glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation", "glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation"], "types": ["T044"], "canonical_name": "glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation", "definition": "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3158045", "aliases": ["regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation", "regulation of FGF receptor signalling pathway of ureteric bud formation", "regulation of FGFR signaling pathway of ureteric bud formation", "regulation of FGF receptor signaling pathway of ureteric bud formation", "regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation"], "types": ["T044"], "canonical_name": "regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation", "definition": "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3158046", "aliases": ["negative regulation of FGF receptor signalling pathway of ureteric bud formation", "negative regulation of FGF receptor signaling pathway of ureteric bud formation", "negative regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation", "negative regulation of FGFR signaling pathway of ureteric bud formation", "negative regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation"], "types": ["T044"], "canonical_name": "negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3158047", "aliases": ["positive regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation", "positive regulation of FGF receptor signalling pathway of ureteric bud formation", "positive regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation", "positive regulation of FGF receptor signaling pathway of ureteric bud formation", "positive regulation of FGFR signaling pathway of ureteric bud formation"], "types": ["T044"], "canonical_name": "positive regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation", "definition": "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3158048", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dense core granule biogenesis", "definition": "Any process that modulates the frequency, rate or extent of dense core granule biogenesis. [GOC:obol]"}
{"concept_id": "C3158049", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of dense core granule biogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis. [GOC:obol]"}
{"concept_id": "C3158050", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of dense core granule biogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis. [GOC:obol]"}
{"concept_id": "C3158051", "aliases": [], "types": ["T043"], "canonical_name": "vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly", "definition": "The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly. [GOC:jid, GOC:mah]"}
{"concept_id": "C3158054", "aliases": ["hh signalling pathway"], "types": ["T044"], "canonical_name": "hh signaling pathway"}
{"concept_id": "C3158055", "aliases": [], "types": ["T044"], "canonical_name": "Shh signaling pathway"}
{"concept_id": "C3158056", "aliases": [], "types": ["T044"], "canonical_name": "Sonic hedgehog signaling pathway"}
{"concept_id": "C3158059", "aliases": [], "types": ["T044"], "canonical_name": "NF-kappaB cascade"}
{"concept_id": "C3158061", "aliases": [], "types": ["T043"], "canonical_name": "neuron-neuron synaptic transmission", "definition": "The process of synaptic transmission from a neuron to another neuron across a synapse. [GOC:add, GOC:dos, GOC:jl, MeSH:D009435]"}
{"concept_id": "C3158063", "aliases": [], "types": ["T042"], "canonical_name": "ectodermal digestive tract development", "definition": "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. [GOC:curators]"}
{"concept_id": "C3158064", "aliases": [], "types": ["T042"], "canonical_name": "progression of morphogenetic furrow involved in compound eye morphogenesis", "definition": "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc. [PMID:3076112, PMID:3937883]"}
{"concept_id": "C3158065", "aliases": [], "types": ["T042"], "canonical_name": "mesoderm migration involved in gastrulation", "definition": "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism. [GOC:isa_complete, GOC:sat]"}
{"concept_id": "C3158067", "aliases": [], "types": ["T044"], "canonical_name": "carboxylate-terminal binding"}
{"concept_id": "C3158068", "aliases": [], "types": ["T044"], "canonical_name": "imaginal disc growth factor receptor binding", "definition": "Binding to an imaginal disc growth factor receptor. [GOC:mah]"}
{"concept_id": "C3158074", "aliases": [], "types": ["T045"], "canonical_name": "pyrimidine-containing compound salvage", "definition": "Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. [GOC:jl]"}
{"concept_id": "C3158075", "aliases": [], "types": ["T044"], "canonical_name": "cholate 7-alpha-dehydrogenase activity", "definition": "Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH. [EC:1.1.1.159, RHEA:19409]"}
{"concept_id": "C3158077", "aliases": [], "types": ["T044"], "canonical_name": "APH(7'') activity"}
{"concept_id": "C3158079", "aliases": ["(S)-malate:(quinone) oxidoreductase activity", "FAD-dependent malate dehydrogenase activity", "(S)-malate:quinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "malate dehydrogenase (quinone) activity", "definition": "Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol. [PMID:234747, RHEA:46012]"}
{"concept_id": "C3158080", "aliases": [], "types": ["T044"], "canonical_name": "MQO activity"}
{"concept_id": "C3158081", "aliases": [], "types": ["T044"], "canonical_name": "ferredoxin-NAD(P) reductase activity", "definition": "Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+. [GOC:curators]"}
{"concept_id": "C3158082", "aliases": [], "types": ["T044"], "canonical_name": "isoprenoid alcohol phosphokinase activity"}
{"concept_id": "C3158087", "aliases": ["triose phosphate translocator", "triose phosphate antiporter", "triose-phosphate:phosphate antiporter activity", "dihydroxyacetone phosphate:phosphate antiporter activity"], "types": ["T044"], "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out). [GOC:bf, GOC:jl, GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-]", "canonical_name": "TPT"}
{"concept_id": "C3158088", "aliases": [], "types": ["T044"], "canonical_name": "cytokinin synthase activity"}
{"concept_id": "C3158089", "aliases": [], "types": ["T044"], "canonical_name": "isopentenyltransferase activity"}
{"concept_id": "C3158090", "aliases": [], "types": ["T043"], "canonical_name": "cell wall modification involved in fruit ripening", "definition": "The series of events resulting in chemical or structural alterations of existing cell walls that contribute to fruit ripening. [GOC:lr]"}
{"concept_id": "C3158091", "aliases": [], "types": ["T043"], "canonical_name": "cell wall modification involved in abscission", "definition": "A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission. [GOC:dph, GOC:lr, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C3158092", "aliases": [], "types": ["T043"], "canonical_name": "plant-type cell wall modification involved in multidimensional cell growth", "definition": "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana. [GOC:lr, GOC:mtg_sensu]"}
{"concept_id": "C3158094", "aliases": ["regulation of signalling pathway"], "types": ["T044"], "canonical_name": "regulation of signaling pathway"}
{"concept_id": "C3158095", "aliases": ["positive regulation of signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of signaling pathway"}
{"concept_id": "C3158096", "aliases": ["negative regulation of signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of signaling pathway"}
{"concept_id": "C3158097", "aliases": [], "types": ["T044"], "canonical_name": "zeinoxanthin epsilon hydroxylase activity", "definition": "Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene. [PMID:8837513, RHEA:57352]"}
{"concept_id": "C3158098", "aliases": [], "types": ["T044"], "canonical_name": "2-(2'-methylthio)ethylmalate synthase activity", "definition": "Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+. [MetaCyc:RXN-2202]"}
{"concept_id": "C3158099", "aliases": ["ent-kaurene oxidation to ent-kaur-16-en-19-oate", "ent-kaurene oxidation to ent-kaurenoate", "ent-kaurene oxidation to kaurenoic acid by ent-kaurene oxidase"], "types": ["T044"], "canonical_name": "ent-kaurene oxidation to kaurenoic acid", "definition": "The three successive oxidations of the 4-methyl group of ent-kaurene to form ent-kaur-16-en-19-oate, kaurenoic acid. This process may be carried out entirely by the enzyme ent-kaurene oxidase. [GOC:tb]"}
{"concept_id": "C3158100", "aliases": ["chlorophyll b synthesis activity", "chlorophyll a oxygenation activity", "chlorophyllide-a oxygenation activity", "chlorophyllide a:oxygen 7-oxidoreduction activity", "chlorophyll-b synthesis activity"], "types": ["T044"], "canonical_name": "chlorophyllide a oxygenase [overall] activity", "definition": "Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. [EC:1.13.12.14, MetaCyc:RXN-7677]"}
{"concept_id": "C3158101", "aliases": ["positive regulation of DNA replication involved in S phase", "positive regulation of DNA replication involved in S-phase"], "types": ["T043"], "canonical_name": "positive regulation of nuclear cell cycle DNA replication", "definition": "Any process that activates or increases the frequency, rate or extent of the DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3158102", "aliases": ["regulation of cell separation after cytokinesis", "regulation of mitotic cytokinetic cell separation"], "types": ["T043"], "canonical_name": "regulation of septum digestion after cytokinesis", "definition": "Any process that modulates the rate, frequency or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806]"}
{"concept_id": "C3158103", "aliases": ["regulation of intracellular protein kinase cascade", "regulation of intracellular signaling chain", "regulation of intracellular signaling cascade", "regulation of intracellular signaling pathway"], "types": ["T044"], "canonical_name": "regulation of intracellular signal transduction", "definition": "Any process that modulates the frequency, rate or extent of intracellular signal transduction. [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]"}
{"concept_id": "C3158104", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of intracellular protein kinase cascade"}
{"concept_id": "C3158105", "aliases": ["down-regulation of intracellular signaling chain", "negative regulation of intracellular signaling cascade", "negative regulation of intracellular signaling chain", "down regulation of intracellular signal transduction", "negative regulation of intracellular protein kinase cascade", "down-regulation of intracellular signal transduction", "downregulation of intracellular signal transduction", "downregulation of intracellular signaling chain", "down-regulation of intracellular signaling pathway", "down regulation of intracellular signaling pathway", "down regulation of intracellular signaling chain"], "types": ["T044"], "canonical_name": "negative regulation of intracellular signal transduction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]"}
{"concept_id": "C3158108", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of phosphatidylinositol 3-kinase cascade"}
{"concept_id": "C3158109", "aliases": [], "types": ["T038"], "canonical_name": "stimulation of phosphatidylinositol 3-kinase cascade"}
{"concept_id": "C3158110", "aliases": [], "types": ["T043"], "canonical_name": "response to purine-containing compound", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. [GOC:ef]"}
{"concept_id": "C3158111", "aliases": ["response to selective serotonin reuptake inhibitor"], "types": ["T043"], "canonical_name": "response to SSRI"}
{"concept_id": "C3158112", "aliases": [], "types": ["T040"], "canonical_name": "regulation of the velocity of shortening of skeletal muscle during contraction"}
{"concept_id": "C3158114", "aliases": [], "types": ["T044"], "canonical_name": "rubredoxin-NADP+ reductase activity", "definition": "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+. [RHEA:13949]"}
{"concept_id": "C3158115", "aliases": [], "types": ["T026"], "definition": "A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle. [PMID:22664348, PMID:24201109]", "canonical_name": "phagophore"}
{"concept_id": "C3158117", "aliases": ["negative regulation of transcription from RNA polymerase II promoter by carbon catabolites"], "types": ["T045"], "canonical_name": "carbon catabolite repression of transcription from RNA polymerase II promoter", "definition": "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. [GOC:krc]"}
{"concept_id": "C3158119", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic cleavage involved in rRNA processing", "definition": "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA. [GOC:krc, PMID:10690410]"}
{"concept_id": "C3158120", "aliases": [], "types": ["T045"], "canonical_name": "meiotic displacement loop biosynthesis"}
{"concept_id": "C3158121", "aliases": [], "types": ["T045"], "canonical_name": "meiotic displacement loop formation"}
{"concept_id": "C3158122", "aliases": [], "types": ["T045"], "canonical_name": "meiotic D-loop dissociation"}
{"concept_id": "C3158123", "aliases": [], "types": ["T045"], "canonical_name": "meiotic D-loop processing"}
{"concept_id": "C3158124", "aliases": [], "types": ["T045"], "canonical_name": "meiotic displacement loop dissociation"}
{"concept_id": "C3158125", "aliases": [], "types": ["T045"], "canonical_name": "meiotic displacement loop processing"}
{"concept_id": "C3158126", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis involved in DNA repair", "definition": "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. [PMID:10357855]"}
{"concept_id": "C3158127", "aliases": [], "types": ["T045"], "canonical_name": "mitotic DNA repair synthesis"}
{"concept_id": "C3158128", "aliases": ["displacement loop dissociation"], "types": ["T045"], "canonical_name": "D-loop dissociation"}
{"concept_id": "C3158129", "aliases": ["displacement loop processing"], "types": ["T045"], "canonical_name": "D-loop processing"}
{"concept_id": "C3158130", "aliases": [], "types": ["T043"], "canonical_name": "karyogamy involved in conjugation with cellular fusion", "definition": "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy. [GOC:elh]"}
{"concept_id": "C3158131", "aliases": ["nuclear congression"], "types": ["T043"], "canonical_name": "nuclear migration involved in conjugation with cellular fusion", "definition": "The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion. [GOC:clt, GOC:vw, PMID:16380440]"}
{"concept_id": "C3158132", "aliases": ["vitamin B5 transmembrane transporter activity"], "types": ["T044"], "canonical_name": "pantothenate transmembrane transporter activity", "definition": "Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. [GOC:ai, ISBN:0721662544]"}
{"concept_id": "C3158133", "aliases": [], "types": ["T044"], "canonical_name": "siderophore-iron transmembrane transporter activity"}
{"concept_id": "C3158134", "aliases": [], "types": ["T044"], "canonical_name": "siderophore uptake transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). [TC:2.A.1.16.1]"}
{"concept_id": "C3158135", "aliases": [], "types": ["T044"], "canonical_name": "ferrioxamine uptake transmembrane transporter activity"}
{"concept_id": "C3158136", "aliases": [], "types": ["T044"], "canonical_name": "siderophore-iron uptake transmembrane transporter activity"}
{"concept_id": "C3158137", "aliases": ["sialic acid:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "sialic acid:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in). [TC:2.A.1.12.1]"}
{"concept_id": "C3158140", "aliases": [], "types": ["T043"], "canonical_name": "CMP-N-acetylneuraminate transport"}
{"concept_id": "C3158144", "aliases": ["pyrimidine base transmembrane transport", "pyrimidine base transport"], "types": ["T043"], "canonical_name": "pyrimidine nucleobase transport", "definition": "The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C3158145", "aliases": [], "types": ["T043"], "canonical_name": "pyrimidine transmembrane transport"}
{"concept_id": "C3158148", "aliases": [], "types": ["T044"], "canonical_name": "chemiosmosis"}
{"concept_id": "C3158149", "aliases": ["synaptic vesicle docking involved in exocytosis"], "types": ["T043"], "canonical_name": "synaptic vesicle docking", "definition": "The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process. [PMID:15217342]"}
{"concept_id": "C3158150", "aliases": [], "types": ["T042"], "canonical_name": "axon pruning"}
{"concept_id": "C3158151", "aliases": [], "types": ["T043"], "canonical_name": "second mitotic wave involved in compound eye morphogenesis", "definition": "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia. [PMID:11257224]"}
{"concept_id": "C3158152", "aliases": [], "types": ["T045"], "canonical_name": "dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome", "definition": "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster. [GOC:jl]"}
{"concept_id": "C3158153", "aliases": [], "types": ["T045"], "canonical_name": "TBP-class protein binding", "definition": "Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]"}
{"concept_id": "C3158154", "aliases": [], "types": ["T045"], "canonical_name": "TBP-related factor (TRF) protein binding"}
{"concept_id": "C3158155", "aliases": ["adrenocorticotropin-releasing hormone"], "types": ["T044"], "canonical_name": "corticotropin-releasing hormone activity", "definition": "The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary. [ISBN:0198506732]"}
{"concept_id": "C3158158", "aliases": [], "types": ["T044"], "canonical_name": "peptide heterocycle biosynthesis"}
{"concept_id": "C3158159", "aliases": [], "types": ["T044"], "canonical_name": "peptide heterocycle biosynthetic process"}
{"concept_id": "C3158160", "aliases": [], "types": ["T044"], "canonical_name": "peptide heterocycle formation"}
{"concept_id": "C3158161", "aliases": [], "types": ["T044"], "canonical_name": "peptide heterocycle synthesis"}
{"concept_id": "C3158165", "aliases": [], "types": ["T044"], "canonical_name": "C-terminal protein amino acid modification", "definition": "The alteration of the C-terminal amino acid residue in a protein. [GOC:mah]"}
{"concept_id": "C3158166", "aliases": [], "types": ["T044"], "canonical_name": "pentaerythritol trinitrate reductase activity", "definition": "Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate. [UM-BBD_reactionID:r0025]"}
{"concept_id": "C3158167", "aliases": ["nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity"], "types": ["T044"], "canonical_name": "nitronate monooxygenase activity", "definition": "Catalysis of the reaction: ethylnitronate + O(2) = acetaldehyde + nitrite. [EC:1.13.12.16, RHEA:28767]"}
{"concept_id": "C3158170", "aliases": ["phenol-containing compound breakdown", "phenol-containing compound degradation", "phenol-containing compound catabolism"], "types": ["T044"], "canonical_name": "phenol-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. [ISBN:0198506732]"}
{"concept_id": "C3158173", "aliases": ["propionate metabolism", "propionate metabolic process", "propanoate metabolism"], "types": ["T044"], "definition": "The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants. [GOC:go_curators, ISBN:0198506732]", "canonical_name": "propanoate metabolic process"}
{"concept_id": "C3158174", "aliases": [], "types": ["T044"], "canonical_name": "3,4-dihydroxybenzoate catabolic process, meta-cleavage"}
{"concept_id": "C3158176", "aliases": ["chloroplast localisation"], "types": ["T038"], "canonical_name": "chloroplast localization", "definition": "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants. [GOC:bf, GOC:jl, ISBN:0198506732]"}
{"concept_id": "C3158177", "aliases": [], "types": ["T044"], "canonical_name": "cyclization of asparagine involved in intein-mediated protein splicing", "definition": "The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing. [RESID:AA0302]"}
{"concept_id": "C3158178", "aliases": [], "types": ["T044"], "canonical_name": "cyclization of glutamine involved in intein-mediated protein splicing", "definition": "The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing. [GOC:dph, GOC:tb, RESID:AA0303]"}
{"concept_id": "C3158179", "aliases": [], "types": ["T026"], "canonical_name": "symbiont-containing vacuole space"}
{"concept_id": "C3158181", "aliases": [], "types": ["T042"], "canonical_name": "principal sensory nucleus of trigeminal nerve development", "definition": "The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C3158184", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell adhesion in ventricular zone"}
{"concept_id": "C3158185", "aliases": [], "types": ["T042"], "canonical_name": "midbrain-hindbrain boundary maturation involved in neural plate development"}
{"concept_id": "C3158186", "aliases": [], "types": ["T043"], "canonical_name": "response to pheromone triggering conjugation with cellular fusion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae. [GOC:clt]"}
{"concept_id": "C3158187", "aliases": [], "types": ["T043"], "canonical_name": "adaptation to pheromone during conjugation with cellular fusion"}
{"concept_id": "C3158189", "aliases": [], "types": ["T043"], "canonical_name": "response to pheromone during pheromone-induced unidirectional"}
{"concept_id": "C3158190", "aliases": [], "types": ["T043"], "canonical_name": "adaptation to pheromone during pheromone-induced unidirectional conjugation"}
{"concept_id": "C3158191", "aliases": [], "types": ["T043"], "canonical_name": "syncytium formation by mitosis without cytokinesis", "definition": "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis. [GOC:mah, GOC:tb]"}
{"concept_id": "C3158197", "aliases": ["transcription regulatory region sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "transcription cis-regulatory region binding", "definition": "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH]"}
{"concept_id": "C3158198", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "definition": "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. [GOC:txnOH]"}
{"concept_id": "C3158199", "aliases": ["RNA polymerase II promoter proximal region sequence-specific DNA binding", "RNA polymerase II core promoter proximal region sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "RNA polymerase II proximal promoter sequence-specific DNA binding"}
{"concept_id": "C3158200", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II core promoter sequence-specific DNA binding", "definition": "Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. [GOC:pg, GOC:txnOH, PMID:12381658]"}
{"concept_id": "C3158201", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II distal enhancer sequence-specific DNA binding"}
{"concept_id": "C3158202", "aliases": ["RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding", "sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity", "RNA polymerase II transcription factor activity, sequence-specific DNA binding", "sequence-specific DNA binding RNA polymerase II transcription factor activity"], "types": ["T044"], "canonical_name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "definition": "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]"}
{"concept_id": "C3158203", "aliases": ["transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding", "transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity"}
{"concept_id": "C3158204", "aliases": ["transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity"}
{"concept_id": "C3158209", "aliases": ["promoter proximal region sequence-specific DNA binding", "core promoter proximal region sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "proximal promoter sequence-specific DNA binding"}
{"concept_id": "C3158214", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III cis-regulatory region sequence-specific DNA binding", "definition": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes. [GOC:txnOH, PMID:12381659]"}
{"concept_id": "C3158215", "aliases": ["RNA polymerase II core binding", "RNAP II core binding"], "types": ["T044"], "canonical_name": "RNA polymerase II complex binding", "definition": "Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. [GOC:txnOH]"}
{"concept_id": "C3158216", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase III core binding", "definition": "Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. [GOC:txnOH]"}
{"concept_id": "C3158217", "aliases": ["core RNA polymerase III binding transcription factor activity"], "types": ["T044"], "canonical_name": "transcription factor activity, core RNA polymerase III binding"}
{"concept_id": "C3158221", "aliases": ["eubacterial-type RNA polymerase core enzyme binding"], "types": ["T044"], "canonical_name": "bacterial-type RNA polymerase core enzyme binding", "definition": "Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit. [GOC:txnOH]"}
{"concept_id": "C3158222", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial single-subunit type RNA polymerase binding", "definition": "Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. [GOC:txnOH, PMID:20701995, PMID:2088182]"}
{"concept_id": "C3158223", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III type 1 promoter sequence-specific DNA binding", "definition": "Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition. [GOC:txnOH, PMID:12381659]"}
{"concept_id": "C3158224", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III type 2 promoter sequence-specific DNA binding", "definition": "Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs. [GOC:txnOH, PMID:12381659]"}
{"concept_id": "C3158229", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III type 3 promoter sequence-specific DNA binding", "definition": "Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae. [GOC:txnOH, PMID:12381659]"}
{"concept_id": "C3158233", "aliases": ["transcription factor activity, sequence-specific DNA binding transcription factor recruiting", "transcription factor activity, sequence-specific DNA-binding transcription factor recruiting", "sequence-specific DNA binding transcription factor recruiting transcription factor activity"], "types": ["T044"], "canonical_name": "RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity", "definition": "The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions. [GOC:txnOH]"}
{"concept_id": "C3158235", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II regulatory region DNA binding"}
{"concept_id": "C3158236", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I regulatory region DNA binding"}
{"concept_id": "C3158237", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA transcription from a type 2 RNA polymerase III promoter"}
{"concept_id": "C3158238", "aliases": ["snoRNA transcription from an RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "snoRNA transcription by RNA polymerase II", "definition": "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. [GOC:txnOH]"}
{"concept_id": "C3158239", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III regulatory region DNA binding"}
{"concept_id": "C3158241", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial RNA polymerase regulatory region DNA binding"}
{"concept_id": "C3158242", "aliases": [], "types": ["T045"], "canonical_name": "plastid promoter transcription regulatory region sequence-specific DNA binding", "definition": "Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. [GOC:txnOH, GOC:vw]"}
{"concept_id": "C3158248", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III transcription factor binding"}
{"concept_id": "C3158256", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III type 1 promoter DNA binding"}
{"concept_id": "C3158257", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III type 2 promoter DNA binding"}
{"concept_id": "C3158258", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III type 3 promoter DNA binding"}
{"concept_id": "C3158261", "aliases": ["RNA polymerase III transcription factor activity, sequence-specific DNA binding"], "types": ["T044"], "canonical_name": "sequence-specific DNA binding RNA polymerase III transcription factor activity"}
{"concept_id": "C3158265", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III hybrid type promoter DNA binding"}
{"concept_id": "C3158267", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III hybrid type promoter sequence-specific DNA binding", "definition": "Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene. [GOC:txnOH, PMID:12381659]"}
{"concept_id": "C3158271", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase I core binding", "definition": "Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. [GOC:txnOH]"}
{"concept_id": "C3158275", "aliases": [], "types": ["T045"], "canonical_name": "core promoter sequence-specific DNA binding", "definition": "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. [GOC:pg, GOC:txnOH]"}
{"concept_id": "C3158276", "aliases": [], "types": ["T045"], "canonical_name": "core promoter binding"}
{"concept_id": "C3158277", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase IV core binding", "definition": "Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production. [GOC:txnOH, PMID:19110459]"}
{"concept_id": "C3158278", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase V core binding", "definition": "Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing. [GOC:txnOH, PMID:19110459]"}
{"concept_id": "C3158279", "aliases": ["T3-type RNA polymerase binding", "SP6-type RNA polymerase binding", "T7-type RNA polymerase binding", "T3/T7 type RNA polymerase binding"], "types": ["T044"], "canonical_name": "single-subunit type RNA polymerase binding", "definition": "Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. [GOC:txnOH, PMID:20701995]"}
{"concept_id": "C3158280", "aliases": [], "types": ["T044"], "canonical_name": "plastid single-subunit type RNA polymerase binding", "definition": "Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. [GOC:txnOH, PMID:20701995]"}
{"concept_id": "C3158281", "aliases": [], "types": ["T044"], "canonical_name": "plastid PEP RNA polymerase core enzyme binding", "definition": "Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit. [GOC:txnOH, PMID:20701995]"}
{"concept_id": "C3158283", "aliases": ["DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter"], "types": ["T045"], "canonical_name": "RNA polymerase IV activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]"}
{"concept_id": "C3158284", "aliases": ["DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter"], "types": ["T045"], "canonical_name": "RNA polymerase V activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]"}
{"concept_id": "C3158285", "aliases": ["transcription from RNA polymerase IV promoter", "transcription from RNA pol IV promoter"], "types": ["T045"], "canonical_name": "transcription by RNA polymerase IV", "definition": "The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter. [GOC:txnOH, PMID:19110459]"}
{"concept_id": "C3158286", "aliases": ["transcription from RNA pol V promoter", "transcription from RNA polymerase V promoter"], "types": ["T045"], "canonical_name": "transcription by RNA polymerase V", "definition": "The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter. [GOC:txnOH, PMID:19110459]"}
{"concept_id": "C3158290", "aliases": ["T3/T7 type RNA polymerase activity"], "types": ["T045"], "canonical_name": "single subunit type RNA polymerase activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]"}
{"concept_id": "C3158291", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial single subunit type RNA polymerase activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]"}
{"concept_id": "C3158292", "aliases": [], "types": ["T045"], "canonical_name": "plastid single subunit type RNA polymerase activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH, PMID:20701995]"}
{"concept_id": "C3158293", "aliases": [], "types": ["T045"], "canonical_name": "regulatory region nucleic acid binding"}
{"concept_id": "C3158294", "aliases": [], "types": ["T045"], "canonical_name": "transcription regulatory region RNA binding", "definition": "Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon. [GOC:txnOH]"}
{"concept_id": "C3158295", "aliases": [], "types": ["T045"], "canonical_name": "regulatory region RNA binding", "definition": "Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. [GOC:txnOH]"}
{"concept_id": "C3158296", "aliases": [], "types": ["T044"], "canonical_name": "RNA binding transcription factor activity"}
{"concept_id": "C3158298", "aliases": ["RNA binding transcription antitermination factor activity"], "types": ["T044"], "canonical_name": "transcription antitermination factor activity, RNA binding", "definition": "Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein. [GOC:txnOH, PMID:8332211]"}
{"concept_id": "C3158299", "aliases": ["DNA binding transcription antitermination factor activity"], "types": ["T044"], "canonical_name": "transcription antitermination factor activity, DNA binding", "definition": "Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein. [GOC:txnOH, PMID:8332211]"}
{"concept_id": "C3158301", "aliases": ["transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly", "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly"], "types": ["T045"], "canonical_name": "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly"}
{"concept_id": "C3158303", "aliases": ["transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding"}
{"concept_id": "C3158304", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding"}
{"concept_id": "C3158305", "aliases": ["regulation of transcription from RNA polymerase II promoter by nitrogen catabolites"], "types": ["T045"], "canonical_name": "nitrogen catabolite regulation of transcription from RNA polymerase II promoter", "definition": "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. [GOC:mah, GOC:txnOH, PMID:19104072]"}
{"concept_id": "C3158306", "aliases": ["positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites"], "types": ["T045"], "canonical_name": "nitrogen catabolite activation of transcription from RNA polymerase II promoter", "definition": "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. [GOC:mah, GOC:txnOH, PMID:19104072]"}
{"concept_id": "C3158307", "aliases": ["negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites"], "types": ["T045"], "canonical_name": "nitrogen catabolite repression of transcription from RNA polymerase II promoter", "definition": "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. [GOC:mah, GOC:txnOH, PMID:19104072]"}
{"concept_id": "C3158317", "aliases": ["RNA polymerase II basal transcription factor binding"], "types": ["T045"], "canonical_name": "RNA polymerase II general transcription initiation factor binding", "definition": "Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. [GOC:txnOH, PMID:16858867]"}
{"concept_id": "C3158318", "aliases": ["TFIIA-class transcription factor binding"], "types": ["T045"], "canonical_name": "TFIIA-class transcription factor complex binding", "definition": "Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. [GOC:krc, PMID:16858867]"}
{"concept_id": "C3158319", "aliases": [], "types": ["T045"], "canonical_name": "TFIIB-class transcription factor binding", "definition": "Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. [GOC:krc, PMID:16858867]"}
{"concept_id": "C3158320", "aliases": ["TFIID-class transcription factor binding"], "types": ["T045"], "canonical_name": "TFIID-class transcription factor complex binding", "definition": "Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. [GOC:krc, PMID:16858867]"}
{"concept_id": "C3158321", "aliases": ["TFIIE-class transcription factor binding"], "types": ["T045"], "canonical_name": "TFIIE-class transcription factor complex binding", "definition": "Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. [GOC:krc, PMID:16858867]"}
{"concept_id": "C3158322", "aliases": ["TFIIF-class transcription factor binding"], "types": ["T045"], "canonical_name": "TFIIF-class transcription factor complex binding", "definition": "Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. [GOC:krc, PMID:16858867]"}
{"concept_id": "C3158323", "aliases": ["TFIIH-class transcription factor binding"], "types": ["T045"], "canonical_name": "TFIIH-class transcription factor complex binding", "definition": "Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. [GOC:krc, PMID:16858867]"}
{"concept_id": "C3158324", "aliases": [], "types": ["T044"], "canonical_name": "basal transcription machinery binding", "definition": "Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. [GOC:txnOH]"}
{"concept_id": "C3158325", "aliases": ["basal RNAP II transcription machinery binding"], "types": ["T044"], "canonical_name": "basal RNA polymerase II transcription machinery binding", "definition": "Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. [GOC:txnOH]"}
{"concept_id": "C3158330", "aliases": ["basal bacterial-type RNA polymerase transcription machinery binding"], "types": ["T044"], "canonical_name": "bacterial-type RNA polymerase holo enzyme binding", "definition": "Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase. [GOC:txnOH]"}
{"concept_id": "C3158331", "aliases": ["promoter clearance during DNA-dependent transcription"], "types": ["T045"], "canonical_name": "promoter clearance during DNA-templated transcription", "definition": "Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. [GOC:txnOH, PMID:15020047, PMID:18280161]"}
{"concept_id": "C3158332", "aliases": [], "types": ["T045"], "canonical_name": "promoter escape"}
{"concept_id": "C3158333", "aliases": [], "types": ["T045"], "canonical_name": "promoter clearance from RNA polymerase III promoter", "definition": "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase. [GOC:txnOH]"}
{"concept_id": "C3158334", "aliases": ["promoter escape from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "promoter clearance from RNA polymerase II promoter", "definition": "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. [GOC:txnOH, PMID:15020047]"}
{"concept_id": "C3158335", "aliases": ["DNA-templated transcriptional open complex formation", "DNA-dependent transcriptional open complex formation"], "types": ["T043"], "canonical_name": "DNA-templated transcription open complex formation", "definition": "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. [GOC:txnOH, PMID:15020047, PMID:18280161]"}
{"concept_id": "C3158336", "aliases": [], "types": ["T043"], "canonical_name": "promoter melting"}
{"concept_id": "C3158337", "aliases": ["transcriptional open complex formation at RNA polymerase II promoter", "RNA polymerase II promoter melting"], "types": ["T043"], "canonical_name": "transcription open complex formation at RNA polymerase II promoter", "definition": "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. [GOC:txnOH, PMID:15020047, PMID:18280161]"}
{"concept_id": "C3158338", "aliases": ["protein-DNA-RNA complex location"], "types": ["T026"], "canonical_name": "protein-DNA-RNA complex", "definition": "A macromolecular complex containing protein, DNA, and RNA molecules. [GOC:txnOH]"}
{"concept_id": "C3158339", "aliases": ["protein-DNA-RNA complex subunit organisation"], "types": ["T043"], "canonical_name": "protein-DNA-RNA complex subunit organization", "definition": "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex. [GOC:txnOH]"}
{"concept_id": "C3158340", "aliases": [], "types": ["T044"], "canonical_name": "protein-DNA-RNA complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex. [GOC:txnOH]"}
{"concept_id": "C3158341", "aliases": [], "types": ["T043"], "canonical_name": "protein-DNA-RNA complex disassembly", "definition": "The disaggregation of a protein-DNA-RNA complex into its constituent components. [GOC:txnOH]"}
{"concept_id": "C3158342", "aliases": ["transcription protein-DNA-RNA complex disassembly"], "types": ["T043"], "canonical_name": "transcription ternary complex disassembly", "definition": "The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components. [GOC:txnOH]"}
{"concept_id": "C3158343", "aliases": [], "types": ["T043"], "canonical_name": "protein-DNA-RNA complex remodeling", "definition": "The acquisition, loss, or modification of macromolecules within a protein-DNA-RNA complex, resulting in the alteration of an existing complex. [GOC:txnOH]"}
{"concept_id": "C3158344", "aliases": [], "types": ["T043"], "canonical_name": "protein-DNA complex remodeling", "definition": "The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex. [GOC:txnOH]"}
{"concept_id": "C3158357", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. [GOC:mtg_signal]"}
{"concept_id": "C3158358", "aliases": ["actin filament reorganisation involved in cell cycle"], "types": ["T043"], "canonical_name": "actin filament reorganization involved in cell cycle", "definition": "The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs. [GOC:mah]"}
{"concept_id": "C3158359", "aliases": [], "types": ["T043"], "canonical_name": "lymphocyte development"}
{"concept_id": "C3158362", "aliases": [], "types": ["T043"], "canonical_name": "B cell development"}
{"concept_id": "C3158365", "aliases": [], "types": ["T043"], "canonical_name": "nuclear fragmentation during apoptosis"}
{"concept_id": "C3158372", "aliases": [], "types": ["T040"], "canonical_name": "pseudocleavage involved in syncytial blastoderm formation", "definition": "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster. [GOC:mtg_sensu]"}
{"concept_id": "C3158378", "aliases": ["myosin filament organisation"], "types": ["T043"], "canonical_name": "myosin filament organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules. [GOC:mah]"}
{"concept_id": "C3158379", "aliases": ["myosin II filament organisation"], "types": ["T043"], "canonical_name": "myosin II filament organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules. [GOC:mah]"}
{"concept_id": "C3158381", "aliases": [], "types": ["T040"], "canonical_name": "slug development during sorocarp development"}
{"concept_id": "C3158382", "aliases": [], "types": ["T040"], "canonical_name": "culmination during sorocarp development"}
{"concept_id": "C3158384", "aliases": [], "types": ["T043"], "canonical_name": "neurite outgrowth"}
{"concept_id": "C3158385", "aliases": ["endoplasmic reticulum palmitoyltransferase complex location"], "types": ["T026"], "canonical_name": "endoplasmic reticulum palmitoyltransferase complex", "definition": "A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue. [GOC:jh]"}
{"concept_id": "C3158386", "aliases": [], "types": ["T043"], "canonical_name": "biomineral formation"}
{"concept_id": "C3158387", "aliases": ["forespore-specific spindle pole body remodeling", "prospore-specific spindle pole body remodeling", "ascospore-type prospore-specific spindle pole body remodelling", "sporulation-specific spindle pole body remodeling", "forespore specific spindle pole body remodeling"], "types": ["T043"], "canonical_name": "ascospore-type prospore-specific spindle pole body remodeling", "definition": "A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP). [GOC:mah, PMID:14702385]"}
{"concept_id": "C3158388", "aliases": [], "types": ["T044"], "canonical_name": "covalent modifier"}
{"concept_id": "C3158392", "aliases": [], "types": ["T026"], "canonical_name": "nodal cilium"}
{"concept_id": "C3158395", "aliases": ["motile cilia"], "types": ["T026"], "definition": "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]", "canonical_name": "motile cilium"}
{"concept_id": "C3158398", "aliases": ["mitotic G2 cell size control checkpoint", "G2 cell size control checkpoint", "mitotic cell cycle G2/M transition size control checkpoint", "G2/M transition size control checkpoint"], "types": ["T043"], "canonical_name": "mitotic G2 cell size control checkpoint signaling", "definition": "A signal transduction process that contributes to a cell size control checkpoint prior to the G2/M transition of mitosis. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3158400", "aliases": [], "types": ["T043"], "canonical_name": "homologous chromosome orientation involved in meiotic metaphase I plate congression", "definition": "The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I. [PMID:15062096]"}
{"concept_id": "C3158408", "aliases": ["bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity"}
{"concept_id": "C3158409", "aliases": ["transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding", "transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity"}
{"concept_id": "C3158419", "aliases": ["core RNA polymerase II recruiting transcription factor activity", "transcription factor activity, core RNA polymerase II recruiting"], "types": ["T044"], "canonical_name": "RNA polymerase II complex recruiting activity", "definition": "Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. [GOC:txnOH, PMID:16858867]"}
{"concept_id": "C3158420", "aliases": ["transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding", "transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding"], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription"}
{"concept_id": "C3158421", "aliases": ["transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding", "transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding"], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription"}
{"concept_id": "C3158427", "aliases": [], "types": ["T045"], "canonical_name": "transcription termination site sequence-specific DNA binding", "definition": "Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH, PMID:18280161, PMID:18391175]"}
{"concept_id": "C3158431", "aliases": ["transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding"], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity"}
{"concept_id": "C3158434", "aliases": ["TFIIIB-class transcription factor binding"], "types": ["T045"], "canonical_name": "TFIIIB-class transcription factor complex binding", "definition": "Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III. [GOC:txnOH, PMID:12381659]"}
{"concept_id": "C3158435", "aliases": [], "types": ["T045"], "canonical_name": "TFIIIA-class transcription factor binding", "definition": "Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters. [GOC:txnOH, PMID:12381659]"}
{"concept_id": "C3158436", "aliases": ["TFIIIC-class transcription factor binding"], "types": ["T045"], "canonical_name": "TFIIIC-class transcription factor complex binding", "definition": "Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III. [GOC:txnOH, PMID:12381659]"}
{"concept_id": "C3158438", "aliases": [], "types": ["T045"], "canonical_name": "enhancer sequence-specific DNA binding"}
{"concept_id": "C3158440", "aliases": [], "types": ["T045"], "canonical_name": "transcription termination site DNA binding"}
{"concept_id": "C3158441", "aliases": [], "types": ["T045"], "canonical_name": "intronic transcription regulatory region sequence-specific DNA binding", "definition": "Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within. [GOC:txnOH]"}
{"concept_id": "C3158442", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding", "definition": "Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within. [GOC:txnOH]"}
{"concept_id": "C3158443", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I transcription regulatory region sequence-specific DNA binding", "definition": "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I. [GOC:txnOH]"}
{"concept_id": "C3158444", "aliases": ["RNA polymerase I CORE element sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "RNA polymerase I core promoter sequence-specific DNA binding", "definition": "Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE. [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]"}
{"concept_id": "C3158445", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I upstream control element sequence-specific DNA binding"}
{"concept_id": "C3158446", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I upstream element sequence-specific DNA binding"}
{"concept_id": "C3158452", "aliases": ["transcription, RNA-dependent"], "types": ["T045"], "canonical_name": "transcription, RNA-templated", "definition": "The cellular synthesis of RNA on a template of RNA. [GOC:txnOH]"}
{"concept_id": "C3158482", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in filamentous growth", "definition": "Relaying of environmental signals promoting filamentous growth. [GOC:mcc, PMID:9728395]"}
{"concept_id": "C3158483", "aliases": ["SMC loading complex location"], "types": ["T026"], "canonical_name": "SMC loading complex", "definition": "A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved. [GOC:curators, GOC:vw, PMID:10882066]"}
{"concept_id": "C3158484", "aliases": ["chromatin loading complex location"], "types": ["T026"], "canonical_name": "chromatin loading complex"}
{"concept_id": "C3158485", "aliases": ["SCC2/SCC4 loading complex location"], "types": ["T026"], "canonical_name": "SCC2/SCC4 loading complex"}
{"concept_id": "C3158489", "aliases": [], "types": ["T043"], "canonical_name": "cell wall macromolecule catabolic process involved in cytogamy", "definition": "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy. [GOC:mah]"}
{"concept_id": "C3158490", "aliases": ["plasma membrane organization involved in conjugation with cellular fusion"], "types": ["T043"], "canonical_name": "plasma membrane fusion involved in cytogamy", "definition": "The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy. [GOC:mah, PMID:29134248]"}
{"concept_id": "C3158491", "aliases": [], "types": ["T043"], "canonical_name": "response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen. [GOC:mah]"}
{"concept_id": "C3158512", "aliases": [], "types": ["T038"], "canonical_name": "regulation of natural killer cell proliferation involved in immune response", "definition": "Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158513", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of natural killer cell proliferation involved in immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158514", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of natural killer cell proliferation involved in immune response", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158515", "aliases": [], "types": ["T043"], "canonical_name": "regulation of natural killer cell development"}
{"concept_id": "C3158516", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of natural killer cell development"}
{"concept_id": "C3158517", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of natural killer cell development"}
{"concept_id": "C3158518", "aliases": [], "types": ["T038"], "canonical_name": "regulation of natural killer cell differentiation involved in immune response", "definition": "Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158519", "aliases": [], "types": ["T038"], "canonical_name": "regulation of natural killer cell development involved in immune response"}
{"concept_id": "C3158520", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of natural killer cell differentiation involved in immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158521", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of natural killer cell development involved in immune response"}
{"concept_id": "C3158522", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of natural killer cell differentiation involved in immune response", "definition": "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158523", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of natural killer cell development involved in immune response"}
{"concept_id": "C3158524", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development"}
{"concept_id": "C3158525", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development"}
{"concept_id": "C3158526", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development"}
{"concept_id": "C3158527", "aliases": [], "types": ["T038"], "canonical_name": "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response", "definition": "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158528", "aliases": [], "types": ["T038"], "canonical_name": "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response"}
{"concept_id": "C3158529", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158530", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response"}
{"concept_id": "C3158533", "aliases": [], "types": ["T044"], "canonical_name": "D-xylose:NADP reductase activity", "definition": "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+. [PMID:12724380, PMID:15184173, RHEA:27445]"}
{"concept_id": "C3158534", "aliases": [], "types": ["T044"], "canonical_name": "D-xylose reductase activity"}
{"concept_id": "C3158535", "aliases": [], "types": ["T044"], "canonical_name": "L-arabinose:NADP reductase activity", "definition": "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+. [PMID:12724380, PMID:15184173, RHEA:25229]"}
{"concept_id": "C3158536", "aliases": [], "types": ["T044"], "canonical_name": "arabinose:NADP reductase activity"}
{"concept_id": "C3158537", "aliases": [], "types": ["T040"], "canonical_name": "regulation of 1,3-beta-glucan metabolic process"}
{"concept_id": "C3158538", "aliases": [], "types": ["T043"], "canonical_name": "regulation of 1,3-beta-glucan biosynthetic process"}
{"concept_id": "C3158541", "aliases": [], "types": ["T038"], "canonical_name": "regulation of mast cell activation involved in immune response", "definition": "Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158542", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of mast cell activation involved in immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158543", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mast cell activation involved in immune response", "definition": "Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. [GOC:mah]"}
{"concept_id": "C3158544", "aliases": [], "types": ["T043"], "canonical_name": "T cell development in thymus"}
{"concept_id": "C3158545", "aliases": [], "types": ["T043"], "canonical_name": "extrathymic T cell development"}
{"concept_id": "C3158546", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T cell development in thymus"}
{"concept_id": "C3158547", "aliases": [], "types": ["T043"], "canonical_name": "regulation of extrathymic T cell development"}
{"concept_id": "C3158548", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of T cell development in thymus"}
{"concept_id": "C3158549", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of extrathymic T cell development"}
{"concept_id": "C3158550", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of T cell development in thymus"}
{"concept_id": "C3158551", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of extrathymic T cell development"}
{"concept_id": "C3158552", "aliases": ["nuclear cell cycle DNA replication", "DNA replication involved in S-phase", "DNA replication involved in S phase"], "types": ["T045"], "canonical_name": "nuclear DNA replication", "definition": "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3158554", "aliases": ["regulation of DNA replication involved in S-phase", "regulation of DNA replication involved in S phase"], "types": ["T043"], "canonical_name": "regulation of nuclear cell cycle DNA replication", "definition": "Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3158560", "aliases": [], "types": ["T044"], "canonical_name": "queuine synthase activity"}
{"concept_id": "C3158561", "aliases": [], "types": ["T044"], "canonical_name": "queuine:NADP+ oxidoreductase activity"}
{"concept_id": "C3158563", "aliases": [], "types": ["T044"], "canonical_name": "endo-alpha-acetylgalactosaminidase activity"}
{"concept_id": "C3158564", "aliases": ["tryptophan synthase alpha subunit activity"], "types": ["T044"], "canonical_name": "tryptophan synthase alpha activity"}
{"concept_id": "C3158567", "aliases": ["small dense low-density lipoprotein particle formation"], "types": ["T043"], "canonical_name": "small dense LDL formation"}
{"concept_id": "C3158572", "aliases": [], "types": ["T044"], "canonical_name": "regulation of plasma lipoprotein particle oxidation"}
{"concept_id": "C3158576", "aliases": [], "types": ["T042"], "canonical_name": "tracheal pit formation in open tracheal system", "definition": "Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584]"}
{"concept_id": "C3158579", "aliases": [], "types": ["T044"], "canonical_name": "ADP receptor activity"}
{"concept_id": "C3158581", "aliases": [], "types": ["T046"], "canonical_name": "fever generation", "definition": "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection. [GOC:dph, GOC:jl]"}
{"concept_id": "C3158582", "aliases": [], "types": ["T040"], "canonical_name": "protostomic gastrulation"}
{"concept_id": "C3158583", "aliases": ["hippo signaling pathway", "hippo signaling cascade", "hippo signaling", "hippo signalling cascade"], "types": ["T043"], "definition": "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. [PMID:17318211, PMID:18328423]", "canonical_name": "hippo signal transduction"}
{"concept_id": "C3158594", "aliases": ["purine nucleoside membrane transport"], "types": ["T043"], "canonical_name": "purine nucleoside transmembrane transport", "definition": "The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar. [GOC:ai, GOC:vw]"}
{"concept_id": "C3158596", "aliases": ["gluconate membrane transport"], "types": ["T043"], "canonical_name": "gluconate transmembrane transport", "definition": "The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. [GOC:vw, ISBN:0198506732]"}
{"concept_id": "C3158597", "aliases": ["regulation of gluconate membrane transport"], "types": ["T043"], "canonical_name": "regulation of gluconate transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore. [GOC:vw]"}
{"concept_id": "C3158598", "aliases": ["down-regulation of gluconate transport", "negative regulation of gluconate membrane transport", "down regulation of gluconate transport", "downregulation of gluconate transport"], "types": ["T043"], "canonical_name": "negative regulation of gluconate transmembrane transport", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore. [GOC:vw]"}
{"concept_id": "C3158599", "aliases": ["up-regulation of gluconate transport", "up regulation of gluconate transport", "positive regulation of gluconate membrane transport", "upregulation of gluconate transport"], "types": ["T043"], "canonical_name": "positive regulation of gluconate transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore. [GOC:vw]"}
{"concept_id": "C3158600", "aliases": ["acetate membrane transport"], "types": ["T043"], "canonical_name": "acetate transmembrane transport", "definition": "The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid. [GOC:vw]"}
{"concept_id": "C3158601", "aliases": ["copper ion membrane transport", "copper cation transmembrane transport"], "types": ["T044"], "canonical_name": "copper ion transmembrane transport", "definition": "The directed movement of copper cation across a membrane. [GOC:vw]"}
{"concept_id": "C3158602", "aliases": ["phosphate ion membrane transport"], "types": ["T044"], "canonical_name": "phosphate ion transmembrane transport", "definition": "The process in which a phosphate is transported across a membrane. [GOC:vw]"}
{"concept_id": "C3158603", "aliases": ["triose phosphate membrane transport"], "types": ["T044"], "canonical_name": "triose phosphate transmembrane transport", "definition": "The process in which triose phosphate (glyceraldehyde 3-phosphate) is transported across a membrane. Glyceraldehyde 3-phosphate is any organic three carbon compound phosphate ester. [GOC:bf, ISBN:0198506732]"}
{"concept_id": "C3158604", "aliases": ["retention of protein in ER", "protein-ER retention", "maintenance of protein location in ER", "retention of protein in endoplasmic reticulum", "maintenance of protein location in endoplasmic reticulum", "maintenance of protein localization in ER", "protein-endoplasmic reticulum retention", "maintenance of protein localisation in endoplasmic reticulum"], "types": ["T038"], "canonical_name": "maintenance of protein localization in endoplasmic reticulum", "definition": "Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum. [GOC:bf, GOC:vw]"}
{"concept_id": "C3158605", "aliases": ["c-di-GMP binding", "3',5'-cyclic di-GMP binding", "cyclic dinucleotide di-GMP binding"], "types": ["T044"], "canonical_name": "cyclic-di-GMP binding", "definition": "Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate. [GOC:bf]"}
{"concept_id": "C3158606", "aliases": ["halimadienyl diphosphate synthase activity", "halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)"], "types": ["T044"], "canonical_name": "halimadienyl-diphosphate synthase activity", "definition": "Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate. [EC:5.5.1.16]"}
{"concept_id": "C3158607", "aliases": ["halima-5,6,dien-15-ol biosynthetic process", "tuberculosinol biosynthesis", "halima-5,6,dien-15-ol biosynthesis"], "types": ["T044"], "canonical_name": "tuberculosinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tuberculosinol (halima-5,6,dien-15-ol), a secondary metabolite in Mycobacteria. [MetaCyc:PWY-5935]"}
{"concept_id": "C3158608", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in vasculogenesis", "definition": "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. [GOC:dgh]"}
{"concept_id": "C3158609", "aliases": ["dipeptide membrane transport"], "types": ["T043"], "canonical_name": "dipeptide transmembrane transport", "definition": "The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. [GOC:vw]"}
{"concept_id": "C3158610", "aliases": ["tripeptide membrane transport"], "types": ["T043"], "canonical_name": "tripeptide transmembrane transport", "definition": "The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds. [GOC:vw]"}
{"concept_id": "C3158611", "aliases": ["nickel cation membrane transport"], "types": ["T044"], "canonical_name": "nickel cation transmembrane transport", "definition": "The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. [GOC:vw]"}
{"concept_id": "C3158612", "aliases": ["borate membrane transport"], "types": ["T044"], "canonical_name": "borate transmembrane transport", "definition": "The process in which borate is transported across a membrane. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals. [GOC:curators]"}
{"concept_id": "C3158613", "aliases": [], "types": ["T043"], "canonical_name": "boron transmembrane transport"}
{"concept_id": "C3158614", "aliases": ["MshC ligase", "L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase"], "types": ["T044"], "canonical_name": "cysteine-glucosaminylinositol ligase activity", "definition": "Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins. [EC:6.3.1.13, MetaCyc:RXN1G-4, PMID:12033919]"}
{"concept_id": "C3158615", "aliases": [], "types": ["T044"], "canonical_name": "desacetylmycothiol synthase"}
{"concept_id": "C3158616", "aliases": ["acetyl-CoA:Cys-GlcN-Ins acetyltransferase"], "types": ["T044"], "canonical_name": "mycothiol synthase activity", "definition": "Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol. [MetaCyc:MONOMER-9684, PMID:12033919]"}
{"concept_id": "C3158617", "aliases": ["peripheral to thylakoid membrane", "extrinsic to thylakoid membrane"], "types": ["T026"], "canonical_name": "extrinsic component of thylakoid membrane", "definition": "The component of a thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:bf, GOC:dos]"}
{"concept_id": "C3158618", "aliases": ["extrinsic to plastid thylakoid membrane", "peripheral to plastid thylakoid membrane"], "types": ["T026"], "canonical_name": "extrinsic component of plastid thylakoid membrane", "definition": "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:bf, GOC:dos]"}
{"concept_id": "C3158619", "aliases": ["extrinsic to lumenal leaflet of plastid thylakoid membrane", "peripheral to lumenal side of plastid thylakoid membrane", "extrinsic to lumenal side of plastid thylakoid membrane"], "types": ["T026"], "canonical_name": "extrinsic component of lumenal side of plastid thylakoid membrane", "definition": "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its lumenal surface, but not integrated into the hydrophobic region. [GOC:bf, GOC:dos]"}
{"concept_id": "C3158620", "aliases": ["extrinsic to stromal side of plastid thylakoid membrane", "extrinsic to stromal leaflet of plastid thylakoid membrane", "peripheral to stromal side of plastid thylakoid membrane"], "types": ["T026"], "canonical_name": "extrinsic component of stromal side of plastid thylakoid membrane", "definition": "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region. [GOC:bf, GOC:dos]"}
{"concept_id": "C3158621", "aliases": ["peripheral to plastid membrane", "extrinsic to plastid membrane"], "types": ["T026"], "canonical_name": "extrinsic component of plastid membrane", "definition": "The component of a plastid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:bf, GOC:dos]"}
{"concept_id": "C3158622", "aliases": ["peripheral to plastid inner membrane", "extrinsic to plastid inner membrane"], "types": ["T026"], "canonical_name": "extrinsic component of plastid inner membrane", "definition": "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:bf, GOC:dos]"}
{"concept_id": "C3158623", "aliases": ["extrinsic to stromal leaflet of plastid inner membrane", "extrinsic to stromal side of plastid inner membrane", "peripheral to stromal side of plastid inner membrane"], "types": ["T026"], "canonical_name": "extrinsic component of stromal side of plastid inner membrane", "definition": "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region. [GOC:bf, GOC:dos]"}
{"concept_id": "C3158624", "aliases": ["response to leukocyte interferon", "response to lymphoblast interferon", "response to lymphoblastoid interferon"], "types": ["T043"], "canonical_name": "response to interferon-alpha", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. [GOC:sl, PMID:11356686]"}
{"concept_id": "C3158625", "aliases": [], "types": ["T043"], "canonical_name": "response to interferon alfa-n1"}
{"concept_id": "C3158626", "aliases": [], "types": ["T043"], "canonical_name": "response to interferon alfa-n3"}
{"concept_id": "C3158627", "aliases": ["response to fibroblast interferon", "response to fiblaferon", "response to interferon beta"], "types": ["T043"], "canonical_name": "response to interferon-beta", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. [GOC:sl, PMID:9561374]"}
{"concept_id": "C3158628", "aliases": [], "types": ["T043"], "canonical_name": "response to beta-1 interferon"}
{"concept_id": "C3158629", "aliases": ["cellular response to leukocyte interferon", "cellular response to lymphoblastoid interferon", "cellular response to lymphoblast interferon"], "types": ["T043"], "canonical_name": "cellular response to interferon-alpha", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. [GOC:sl]"}
{"concept_id": "C3158630", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to interferon alfa-n1"}
{"concept_id": "C3158631", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to interferon alfa-n3"}
{"concept_id": "C3158632", "aliases": ["cellular response to fibroblast interferon", "cellular response to fiblaferon"], "types": ["T043"], "canonical_name": "cellular response to interferon-beta", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. [GOC:sl]"}
{"concept_id": "C3158633", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to beta-1 interferon"}
{"concept_id": "C3158634", "aliases": ["cargo loading into vesicle", "cargo selection"], "types": ["T044"], "canonical_name": "vesicle cargo loading", "definition": "The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle. [GOC:bf, GOC:lb]"}
{"concept_id": "C3158635", "aliases": [], "types": ["T044"], "canonical_name": "L-ascorbate 6-phosphate lactonase activity", "definition": "Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate. [PMID:18097099, PMID:20359483]"}
{"concept_id": "C3158636", "aliases": ["vitamin membrane transport"], "types": ["T085"], "canonical_name": "vitamin transmembrane transport", "definition": "The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:bf]"}
{"concept_id": "C3158637", "aliases": [], "types": ["T040"], "canonical_name": "determination of left/right asymmetry in diencephalon", "definition": "The establishment of the diencephalon with respect to the left and right halves. [GOC:dgh, PMID:15084459]"}
{"concept_id": "C3158638", "aliases": ["TGFbeta receptor signalling pathway involved in determination of left/right asymmetry", "TGFbeta receptor signaling pathway involved in determination of left/right asymmetry", "TGF-beta receptor signaling pathway involved in determination of left/right asymmetry", "transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry", "TGF-beta receptor signalling pathway involved in determination of left/right asymmetry"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves. [GOC:dgh, GOC:signaling]"}
{"concept_id": "C3158639", "aliases": ["regulation of TGF-beta receptor signaling pathway involved in determination of left/right asymmetry", "regulation of TGFbeta receptor signaling pathway involved in determination of left/right asymmetry", "regulation of TGFbeta receptor signalling pathway involved in determination of left/right asymmetry", "regulation of TGF-beta receptor signalling pathway involved in determination of left/right asymmetry", "regulation of transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry"], "types": ["T044"], "canonical_name": "regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry", "definition": "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of organismal asymmetry with regard to its left and right halves. [GOC:dgh]"}
{"concept_id": "C3158641", "aliases": [], "types": ["T040"], "canonical_name": "determination of pancreatic left/right asymmetry", "definition": "Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism. [GOC:dgh, PMID:12702646]"}
{"concept_id": "C3158642", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of vascular wound healing", "definition": "Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:rph]"}
{"concept_id": "C3158643", "aliases": ["luteinizing hormone signalling pathway involved in ovarian follicle development"], "types": ["T042"], "canonical_name": "luteinizing hormone signaling pathway involved in ovarian follicle development", "definition": "The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure. [GOC:bf]"}
{"concept_id": "C3158644", "aliases": ["chorionic gonadotropin hormone receptor", "CG receptor activity", "chorio-gonadotrophin receptor activity"], "types": ["T044"], "canonical_name": "choriogonadotropin hormone receptor activity", "definition": "Combining with the choriogonadotropin hormone to initiate a change in cell activity. [GOC:bf, ISBN:0198506732, PMID:1922095]"}
{"concept_id": "C3158645", "aliases": [], "types": ["T044"], "canonical_name": "lipase binding", "definition": "Binding to a lipase. [GOC:BHF]"}
{"concept_id": "C3158646", "aliases": [], "types": ["T042"], "canonical_name": "selective angioblast sprouting", "definition": "The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel. [GOC:dgh, PMID:19815777]"}
{"concept_id": "C3158647", "aliases": [], "types": ["T043"], "canonical_name": "angioblast cell migration involved in selective angioblast sprouting", "definition": "The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations. [GOC:dgh, PMID:19815777]"}
{"concept_id": "C3158648", "aliases": [], "types": ["T043"], "canonical_name": "angioblast cell migration", "definition": "The orderly movement of angioblasts, cells involved in blood vessel morphogenesis. [GOC:dgh, PMID:19815777]"}
{"concept_id": "C3158649", "aliases": [], "types": ["T038"], "canonical_name": "regulation of angioblast cell migration involved in selective angioblast sprouting", "definition": "Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting. [GOC:dgh, PMID:19815777]"}
{"concept_id": "C3158650", "aliases": [], "types": ["T044"], "canonical_name": "chylomicron binding", "definition": "Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. [GOC:BHF, PMID:17403372]"}
{"concept_id": "C3158651", "aliases": [], "types": ["T043"], "canonical_name": "angioblast cell migration from lateral mesoderm to midline", "definition": "The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature. [GOC:dgh, PMID:11861480]"}
{"concept_id": "C3158652", "aliases": ["regulation of Notch signalling pathway involved in heart induction"], "types": ["T044"], "canonical_name": "regulation of Notch signaling pathway involved in heart induction", "definition": "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction. [GOC:BHF]"}
{"concept_id": "C3158653", "aliases": ["positive regulation of Notch signalling pathway involved in heart induction"], "types": ["T044"], "canonical_name": "positive regulation of Notch signaling pathway involved in heart induction", "definition": "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction. [GOC:BHF]"}
{"concept_id": "C3158654", "aliases": ["A/A mispair binding"], "types": ["T045"], "canonical_name": "adenine/adenine mispair binding", "definition": "Binding to a double-stranded DNA region containing an A/A mispair. [GOC:bf, GOC:jh]"}
{"concept_id": "C3158655", "aliases": ["G/A mispair binding", "A/G mispair binding", "guanine-adenine mispair binding"], "types": ["T045"], "canonical_name": "adenine/guanine mispair binding", "definition": "Binding to a double-stranded DNA region containing an A/G mispair. [GOC:bf, GOC:jh]"}
{"concept_id": "C3158657", "aliases": ["C/C mispair binding"], "types": ["T045"], "canonical_name": "cytosine/cytosine mispair binding", "definition": "Binding to a double-stranded DNA region containing a C/C mispair. [GOC:bf, GOC:jh]"}
{"concept_id": "C3158658", "aliases": ["T/T mispair binding"], "types": ["T045"], "canonical_name": "thymine/thymine mispair binding", "definition": "Binding to a double-stranded DNA region containing a T/T mispair. [GOC:bf, GOC:jh]"}
{"concept_id": "C3158659", "aliases": ["T/C mispair binding", "thymine/cytosine mispair binding", "C/T mispair binding"], "types": ["T045"], "canonical_name": "cytosine/thymine mispair binding", "definition": "Binding to a double-stranded DNA region containing a C/T mispair. [GOC:bf, GOC:jh]"}
{"concept_id": "C3158660", "aliases": ["G/G mispair binding"], "types": ["T045"], "canonical_name": "guanine/guanine mispair binding", "definition": "Binding to a double-stranded DNA region containing a G/G mispair. [GOC:bf, GOC:jh]"}
{"concept_id": "C3158661", "aliases": [], "types": ["T038"], "canonical_name": "regulation of leukotriene production involved in inflammatory response", "definition": "Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. [GOC:bf]"}
{"concept_id": "C3158662", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of leukotriene production involved in inflammatory response", "definition": "Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. [GOC:bf]"}
{"concept_id": "C3158663", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of leukotriene production involved in inflammatory response", "definition": "Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. [GOC:bf]"}
{"concept_id": "C3158664", "aliases": [], "types": ["T044"], "canonical_name": "SNARE complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb, PMID:10872468]"}
{"concept_id": "C3158665", "aliases": [], "types": ["T044"], "canonical_name": "SNARE complex disassembly", "definition": "The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb, PMID:11697877]"}
{"concept_id": "C3158666", "aliases": [], "types": ["T044"], "canonical_name": "regulation of SNARE complex disassembly", "definition": "Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb]"}
{"concept_id": "C3158667", "aliases": ["UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase", "LPS-1,5-galactosyltransferase activity"], "types": ["T044"], "canonical_name": "lipopolysaccharide-1,5-galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide. [PMID:11304545]"}
{"concept_id": "C3158668", "aliases": ["cAMP-responsive element binding", "cyclic-AMP response element binding", "CRE binding", "cyclic AMP response element binding", "cyclic-AMP-responsive element binding"], "types": ["T045"], "canonical_name": "cAMP response element binding", "definition": "Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. [PMID:2875459, PMID:2900470]"}
{"concept_id": "C3158669", "aliases": ["carnosine metabolism"], "types": ["T044"], "canonical_name": "carnosine metabolic process", "definition": "The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine). [PMID:20097752]"}
{"concept_id": "C3158670", "aliases": ["carnosine synthesis", "carnosine formation", "carnosine biosynthesis", "carnosine anabolism"], "types": ["T044"], "canonical_name": "carnosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine). [EC:6.3.2.11, PMID:20097752]"}
{"concept_id": "C3158671", "aliases": ["MAD homology 2 domain binding"], "types": ["T044"], "canonical_name": "MH2 domain binding", "definition": "Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. [GOC:curators]"}
{"concept_id": "C3158672", "aliases": ["MAD homology 1 domain binding"], "types": ["T044"], "canonical_name": "MH1 domain binding", "definition": "Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors. [Pfam:PF03165]"}
{"concept_id": "C3158675", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myosin light chain kinase activity", "definition": "Any process that modulates the frequency, rate or extent of myosin light chain kinase activity. [GOC:bf, GOC:go_curators]"}
{"concept_id": "C3158676", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of myosin light chain kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity. [GOC:bf, GOC:go_curators]"}
{"concept_id": "C3158677", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myosin light chain kinase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity. [GOC:bf, GOC:go_curators]"}
{"concept_id": "C3158678", "aliases": [], "types": ["T044"], "canonical_name": "regulation of myosin-light-chain-phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity. [GOC:bf, GOC:go_curators]"}
{"concept_id": "C3158679", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of myosin-light-chain-phosphatase activity", "definition": "Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity. [GOC:bf, GOC:go_curators]"}
{"concept_id": "C3158680", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of myosin-light-chain-phosphatase activity", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity. [GOC:bf, GOC:go_curators]"}
{"concept_id": "C3158681", "aliases": [], "types": ["T045"], "canonical_name": "DNA dealkylation", "definition": "The removal of an alkyl group from one or more nucleotides within an DNA molecule. [GOC:bf]"}
{"concept_id": "C3158682", "aliases": [], "types": ["T044"], "canonical_name": "oxidative DNA demethylation", "definition": "Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. [PMID:12594517, PMID:16482161, PMID:18775698]"}
{"concept_id": "C3158683", "aliases": [], "types": ["T045"], "canonical_name": "hydrolytic DNA demethylation", "definition": "The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule. [GOC:bf]"}
{"concept_id": "C3158684", "aliases": [], "types": ["T045"], "canonical_name": "oxidative RNA demethylation", "definition": "The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms. [PMID:12594517, PMID:16482161, PMID:18775698]"}
{"concept_id": "C3158685", "aliases": ["2-oxoglutarate-dependent RNA demethylase"], "types": ["T044"], "canonical_name": "oxidative RNA demethylase activity", "definition": "Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. [PMID:12594517, PMID:16482161, PMID:18775698]"}
{"concept_id": "C3158686", "aliases": ["2-oxoglutarate-dependent DNA demethylase"], "types": ["T044"], "canonical_name": "oxidative DNA demethylase activity", "definition": "Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O(2) = a nucleobase within DNA + formaldehyde + succinate + CO(2). [PMID:12594517, PMID:16482161, PMID:18775698, RHEA:30299]"}
{"concept_id": "C3158687", "aliases": ["PR-DUB complex location", "Polycomb repressive deubiquitinase complex", "Polycomb repressive deubiquitinase complex location"], "types": ["T026"], "canonical_name": "PR-DUB complex", "definition": "A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively. [PMID:20436459]"}
{"concept_id": "C3158688", "aliases": [], "types": ["T044"], "canonical_name": "histone H2A monoubiquitination", "definition": "The modification of histone H2A by addition of a single ubiquitin group. [PMID:18206970]"}
{"concept_id": "C3158689", "aliases": ["protein K29-linked polyubiquitination"], "types": ["T044"], "canonical_name": "protein K29-linked ubiquitination", "definition": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation. [PMID:17028573]"}
{"concept_id": "C3158690", "aliases": ["monoubiquitinated protein deubiquitylation", "monoubiquitinated protein deubiquitinylation"], "types": ["T044"], "canonical_name": "monoubiquitinated protein deubiquitination", "definition": "The removal of the ubiquitin group from a monoubiquitinated protein. [GOC:bf]"}
{"concept_id": "C3158691", "aliases": ["monoubiquitinated histone deubiquitylation", "monoubiquitinated histone deubiquitinylation"], "types": ["T044"], "canonical_name": "monoubiquitinated histone deubiquitination", "definition": "The removal of the ubiquitin group from a monoubiquitinated histone protein. [GOC:bf, PMID:20436459]"}
{"concept_id": "C3158692", "aliases": ["monoubiquitinated histone H2A deubiquitinylation", "monoubiquitinated histone H2A deubiquitylation"], "types": ["T044"], "canonical_name": "monoubiquitinated histone H2A deubiquitination", "definition": "The removal of the ubiquitin group from a monoubiquitinated histone H2A protein. [GOC:bf, PMID:18226187, PMID:20436459]"}
{"concept_id": "C3158693", "aliases": ["protein K29-linked deubiquitylation", "protein K29-linked deubiquitinylation"], "types": ["T044"], "canonical_name": "protein K29-linked deubiquitination", "definition": "A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein. [GOC:bf]"}
{"concept_id": "C3158694", "aliases": ["proline membrane transport"], "types": ["T043"], "canonical_name": "proline transmembrane transport", "definition": "The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore. [GOC:vw]"}
{"concept_id": "C3158695", "aliases": ["NF-kappa B1/p65 complex", "NF-kappaB p50/p65 complex location", "NF-kappa B1/RelA complex location", "NF-kappa B1/p65 complex location", "NF-kappa p50/RelA complex", "NF-kappa p50/RelA complex location", "NF-kappa B1/RelA complex"], "types": ["T026"], "canonical_name": "NF-kappaB p50/p65 complex", "definition": "A heterodimer of NF-kappa B p50 and p65 subunits. [GO:add, PMID:20393192, PMID:9299584]"}
{"concept_id": "C3158696", "aliases": ["NF-kappa p105/p65 complex location"], "types": ["T026"], "canonical_name": "NF-kappa p105/p65 complex"}
{"concept_id": "C3158697", "aliases": ["NF-kappa p105/RelA complex location"], "types": ["T026"], "canonical_name": "NF-kappa p105/RelA complex"}
{"concept_id": "C3158698", "aliases": [], "types": ["T043"], "canonical_name": "retrograde transport, plasma membrane to Golgi", "definition": "The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles. [GOC:lb, PMID:17488291]"}
{"concept_id": "C3158699", "aliases": ["3-hydroxypropionate:NADP+ oxidoreductase", "3-hydroxypropanoate dehydrogenase (NADP+) activity", "3-hydroxypropanoate:NADP+ oxidoreductase"], "types": ["T044"], "canonical_name": "3-hydroxypropionate dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH. [RHEA:26438]"}
{"concept_id": "C3158701", "aliases": ["CCL6 production"], "types": ["T040"], "canonical_name": "chemokine (C-C motif) ligand 6 production", "definition": "The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, PMID:19812544]"}
{"concept_id": "C3158702", "aliases": ["regulation of CCL6 production"], "types": ["T040"], "canonical_name": "regulation of chemokine (C-C motif) ligand 6 production", "definition": "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6). [GOC:add, GOC:bf]"}
{"concept_id": "C3158703", "aliases": ["negative regulation of CCL6 production"], "types": ["T040"], "canonical_name": "negative regulation of chemokine (C-C motif) ligand 6 production", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6). [GOC:add, GOC:bf]"}
{"concept_id": "C3158704", "aliases": ["positive regulation of CCL6 production"], "types": ["T040"], "canonical_name": "positive regulation of chemokine (C-C motif) ligand 6 production", "definition": "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6). [GOC:add, GOC:bf]"}
{"concept_id": "C3158709", "aliases": ["ChoRE binding"], "types": ["T045"], "canonical_name": "carbohydrate response element binding", "definition": "Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes. [GOC:BHF, PMID:20001964]"}
{"concept_id": "C3158710", "aliases": ["8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity", "8-oxo-dGTPase activity", "8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity", "8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity", "8-oxo-dGTP pyrophosphohydrolase activity"], "types": ["T044"], "canonical_name": "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity", "definition": "Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. [PMID:17804481, PMID:7782328, PMID:7859359, RHEA:31575]"}
{"concept_id": "C3158711", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of SNARE complex disassembly", "definition": "Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb]"}
{"concept_id": "C3158712", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of SNARE complex disassembly", "definition": "Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb]"}
{"concept_id": "C3158713", "aliases": [], "types": ["T043"], "canonical_name": "regulation of SNARE complex assembly", "definition": "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb]"}
{"concept_id": "C3158714", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of SNARE complex assembly", "definition": "Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb]"}
{"concept_id": "C3158715", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of SNARE complex assembly", "definition": "Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb]"}
{"concept_id": "C3158716", "aliases": [], "types": ["T040"], "canonical_name": "determination of left/right asymmetry in nervous system", "definition": "The establishment of the nervous system with respect to the left and right halves. [GOC:kmv, PMID:17717195, PMID:19641012]"}
{"concept_id": "C3158724", "aliases": ["urease complex location"], "types": ["T026"], "canonical_name": "urease complex", "definition": "A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide). [InterPro:IPR008221, PMID:2651866]"}
{"concept_id": "C3158725", "aliases": [], "types": ["T044"], "canonical_name": "protein initiator methionine removal involved in protein maturation", "definition": "Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein. [GOC:bf, GOC:hjd, GOC:vw]"}
{"concept_id": "C3158726", "aliases": ["oxidative ssDNA demethylation"], "types": ["T044"], "canonical_name": "oxidative single-stranded DNA demethylation", "definition": "Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. [GOC:BHF, GOC:rl, PMID:18775698]"}
{"concept_id": "C3158727", "aliases": ["oxidative ssRNA demethylation"], "types": ["T045"], "canonical_name": "oxidative single-stranded RNA demethylation", "definition": "Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. [GOC:BHF, GOC:rl, PMID:18775698]"}
{"concept_id": "C3158728", "aliases": [], "types": ["T039"], "canonical_name": "termination of Roundabout signal transduction", "definition": "The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated. [GOC:BHF, GOC:vk]"}
{"concept_id": "C3158730", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction via intracellular signaling cascade"}
{"concept_id": "C3158734", "aliases": ["PPD activity", "phedase activity"], "types": ["T044"], "canonical_name": "pheophoridase activity"}
{"concept_id": "C3158735", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chromatin binding", "definition": "Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:bf, PMID:20404130]"}
{"concept_id": "C3158736", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of chromatin binding", "definition": "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:bf, PMID:20404130]"}
{"concept_id": "C3158737", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of chromatin binding", "definition": "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:bf, PMID:20404130]"}
{"concept_id": "C3158738", "aliases": [], "types": ["T038"], "canonical_name": "regulation of kidney size", "definition": "Any process that modulates the size of a kidney. [GOC:bf]"}
{"concept_id": "C3158739", "aliases": ["regulation of pronephric kidney size"], "types": ["T038"], "canonical_name": "regulation of pronephros size", "definition": "Any process that modulates the size of a pronephric kidney. [GOC:bf]"}
{"concept_id": "C3158740", "aliases": ["regulation of metanephric kidney size"], "types": ["T038"], "canonical_name": "regulation of metanephros size", "definition": "Any process that modulates the size of a metanephric kidney. [GOC:bf]"}
{"concept_id": "C3158742", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-proline methylation", "definition": "The methylation of the N-terminal proline of proteins. [PMID:20668449, RESID:AA0419]"}
{"concept_id": "C3158744", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-serine methylation", "definition": "The methylation of the N-terminal serine of proteins. [PMID:20668449]"}
{"concept_id": "C3158745", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-serine monomethylation", "definition": "The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine. [PMID:20668449]"}
{"concept_id": "C3158746", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-serine dimethylation", "definition": "The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine. [PMID:20668449]"}
{"concept_id": "C3158747", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal peptidyl-serine trimethylation", "definition": "The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine. [PMID:20668449]"}
{"concept_id": "C3158748", "aliases": [], "types": ["T044"], "canonical_name": "histone H4-K20 demethylation", "definition": "The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone. [GOC:sp, PMID:20622853]"}
{"concept_id": "C3158749", "aliases": ["histone H4K20me demethylase activity", "histone demethylase activity (H4-K20 specific)"], "types": ["T044"], "canonical_name": "histone H4-methyl-lysine-20 demethylase activity", "definition": "Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:20622853, PMID:26214369, PMID:32209475]"}
{"concept_id": "C3158750", "aliases": ["retinoic acid receptor signalling pathway involved in pronephric field specification"], "types": ["T044"], "canonical_name": "retinoic acid receptor signaling pathway involved in pronephric field specification", "definition": "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in regions of the embryo being delineated into the area in which the pronephric kidney will develop. [GOC:bf, PMID:16979153, PMID:19909807]"}
{"concept_id": "C3158751", "aliases": ["primary granule membrane"], "types": ["T026"], "canonical_name": "azurophil granule membrane", "definition": "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095]"}
{"concept_id": "C3158752", "aliases": ["primary granule lumen"], "types": ["T026"], "canonical_name": "azurophil granule lumen", "definition": "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095]"}
{"concept_id": "C3158753", "aliases": ["secondary granule membrane"], "types": ["T026"], "canonical_name": "specific granule membrane", "definition": "The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]"}
{"concept_id": "C3158754", "aliases": ["secondary granule lumen"], "types": ["T026"], "canonical_name": "specific granule lumen", "definition": "The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]"}
{"concept_id": "C3158755", "aliases": ["extracellular sequestering of receptor ligand"], "types": ["T044"], "canonical_name": "sequestering of extracellular ligand from receptor", "definition": "The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor. [GOC:BHF, GOC:signaling]"}
{"concept_id": "C3158756", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein bioavailability"}
{"concept_id": "C3158759", "aliases": ["calcium-mediated signalling using intracellular calcium source", "calcium signaling using intracellular calcium source", "calcium signalling using intracellular calcium source"], "types": ["T043"], "canonical_name": "calcium-mediated signaling using intracellular calcium source", "definition": "The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. [GOC:bf, GOC:BHF, PMID:20192754]"}
{"concept_id": "C3158760", "aliases": ["calcium signalling using extracellular calcium source", "calcium-mediated signalling using extracellular calcium source", "calcium signaling using extracellular calcium source"], "types": ["T043"], "canonical_name": "calcium-mediated signaling using extracellular calcium source", "definition": "The series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response. [GOC:bf, GOC:BHF, PMID:20192754]"}
{"concept_id": "C3158761", "aliases": [], "types": ["T043"], "canonical_name": "extracellular calcium influx"}
{"concept_id": "C3158762", "aliases": ["purinergic receptor signalling pathway"], "types": ["T044"], "canonical_name": "purinergic receptor signaling pathway"}
{"concept_id": "C3158763", "aliases": ["G-protein coupled purinergic receptor signalling pathway", "G-protein coupled purinergic receptor signaling pathway"], "types": ["T044"], "canonical_name": "G protein-coupled purinergic receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by an extracellular purine or purine derivative binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:BHF, PMID:9755289]"}
{"concept_id": "C3158764", "aliases": ["G-protein coupled purinergic nucleotide receptor signaling pathway", "G-protein coupled purinergic nucleotide receptor signalling pathway", "P2Y receptor signaling pathway"], "types": ["T044"], "canonical_name": "G protein-coupled purinergic nucleotide receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:BHF, PMID:9755289]"}
{"concept_id": "C3158765", "aliases": ["purinergic nucleotide receptor signalling pathway"], "types": ["T044"], "canonical_name": "purinergic nucleotide receptor signaling pathway", "definition": "The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, PMID:9755289]"}
{"concept_id": "C3158766", "aliases": [], "types": ["T044"], "canonical_name": "P2 receptor signaling pathway"}
{"concept_id": "C3158767", "aliases": ["signalling adaptor activity"], "types": ["T044"], "canonical_name": "signaling adaptor activity", "definition": "The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. [GOC:bf, PMID:19104498]"}
{"concept_id": "C3158768", "aliases": ["establishment of protein localization in extracellular region", "establishment of protein localisation in extracellular region"], "types": ["T043"], "canonical_name": "establishment of protein localization to extracellular region", "definition": "The directed movement of a protein to a specific location within the extracellular region. [GOC:bf, GOC:BHF]"}
{"concept_id": "C3158769", "aliases": ["positive regulation of Wnt-activated signaling pathway by establishment of Wnt protein localization to extracellular region", "positive regulation of Wnt receptor signalling pathway by establishment of Wnt protein localization in extracellular region", "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localisation in extracellular region", "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization in extracellular region", "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region"], "types": ["T043"], "canonical_name": "positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region", "definition": "Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region. [GOC:BHF, PMID:19906850]"}
{"concept_id": "C3158770", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt diffusion"}
{"concept_id": "C3158771", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt signaling range"}
{"concept_id": "C3158772", "aliases": [], "types": ["T044"], "canonical_name": "ganglioside binding", "definition": "Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues. [GOC:yaf]"}
{"concept_id": "C3158773", "aliases": ["GlcNAc-Ins deacetylase activity", "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase activity", "1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase activity", "N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity"], "types": ["T044"], "canonical_name": "N-acetylglucosaminylinositol deacetylase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol. [EC:3.5.1.103, GOC:rs]"}
{"concept_id": "C3158774", "aliases": ["MTTase"], "types": ["T044"], "canonical_name": "methylthiotransferase activity", "definition": "Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor. [GOC:jh2, PMID:20472640]"}
{"concept_id": "C3158775", "aliases": ["i6A methylthiotransferase activity"], "types": ["T044"], "canonical_name": "N6-isopentenyladenosine methylthiotransferase activity", "definition": "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A). [PMID:20472640]"}
{"concept_id": "C3158776", "aliases": ["t6A methylthiotransferase activity"], "types": ["T044"], "canonical_name": "N6-threonylcarbomyladenosine methylthiotransferase activity", "definition": "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A). [PMID:20472640, PMID:20584901]"}
{"concept_id": "C3158777", "aliases": [], "types": ["T044"], "canonical_name": "aspartic acid methylthiotransferase activity", "definition": "Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid. [PMID:18252828, PMID:8844851, RESID:AA0232]"}
{"concept_id": "C3158778", "aliases": [], "types": ["T045"], "canonical_name": "tRNA methylthiolation", "definition": "The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule. [PMID:20472640]"}
{"concept_id": "C3158779", "aliases": ["protein amino acid deacylation"], "types": ["T044"], "canonical_name": "protein deacylation", "definition": "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid. [GOC:se, PMID:12080046]"}
{"concept_id": "C3158780", "aliases": ["fibroblast growth factor receptor signalling pathway involved in negative regulation of apoptotic process in bone marrow", "FGFR signaling pathway involved in negative regulation of apoptosis in bone marrow", "FGF receptor signaling pathway involved in negative regulation of apoptosis in bone marrow", "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow", "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow. [GOC:mtg_apoptosis, GOC:yaf]"}
{"concept_id": "C3158781", "aliases": ["FGF receptor signaling pathway involved in hematopoiesis", "fibroblast growth factor receptor signaling pathway involved in hematopoiesis", "fibroblast growth factor receptor signalling pathway involved in hemopoiesis", "FGFR signaling pathway involved in hematopoiesis"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in hemopoiesis", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis. [GOC:yaf]"}
{"concept_id": "C3158782", "aliases": ["FGF receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow", "fibroblast growth factor receptor signalling pathway involved in positive regulation of cell proliferation in bone marrow", "FGFR signaling pathway involved in positive regulation of cell proliferation in bone marrow"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow. [GOC:yaf]"}
{"concept_id": "C3158783", "aliases": ["S-nitrosylase activity"], "types": ["T044"], "canonical_name": "peptidyl-cysteine S-nitrosylase activity", "definition": "Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein. [EC:2.6.99.-, GOC:sp, PMID:20972425, PMID:20972426]"}
{"concept_id": "C3158784", "aliases": [], "types": ["T044"], "canonical_name": "protein nitrosylase activity"}
{"concept_id": "C3158785", "aliases": ["cysteine-to-cysteine transnitrosylation", "cysteine to cysteine nitrosylation", "S-transnitrosylation"], "types": ["T044"], "canonical_name": "peptidyl-cysteine S-trans-nitrosylation", "definition": "Transfer of a nitric oxide (NO) group from one cysteine residue to another. [PMID:19854201, PMID:20972425, PMID:20972426]"}
{"concept_id": "C3158786", "aliases": [], "types": ["T044"], "canonical_name": "protein-to-protein transnitrosylation"}
{"concept_id": "C3158787", "aliases": ["FGF receptor signaling pathway involved in orbitofrontal cortex development", "FGFR signaling pathway involved in orbitofrontal cortex development", "fibroblast growth factor receptor signalling pathway involved in orbitofrontal cortex development"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development", "definition": "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state. [GOC:yaf]"}
{"concept_id": "C3158788", "aliases": ["protein amino acid deglutamylation"], "types": ["T044"], "canonical_name": "protein deglutamylation", "definition": "The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation. [GOC:sp, PMID:21074048]"}
{"concept_id": "C3158789", "aliases": ["protein primary sequence deglutamylation"], "types": ["T044"], "canonical_name": "C-terminal protein deglutamylation", "definition": "The removal of a C-terminal, gene-encoded glutamate residue from a protein. [GOC:sp, PMID:21074048]"}
{"concept_id": "C3158790", "aliases": ["removal of posttranslational polyglutamylation"], "types": ["T044"], "canonical_name": "protein side chain deglutamylation", "definition": "The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation. [GOC:sp, PMID:21074048]"}
{"concept_id": "C3158791", "aliases": [], "types": ["T044"], "canonical_name": "shortening of glutamate side chain"}
{"concept_id": "C3158792", "aliases": [], "types": ["T044"], "canonical_name": "protein branching point deglutamylation", "definition": "The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue. [GOC:sp, PMID:21074048]"}
{"concept_id": "C3158793", "aliases": [], "types": ["T044"], "canonical_name": "AP-2 adaptor complex binding", "definition": "Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499]"}
{"concept_id": "C3158794", "aliases": [], "types": ["T044"], "canonical_name": "AP-2 clathrin adaptor complex binding"}
{"concept_id": "C3158795", "aliases": ["RNA hairpin binding", "RNA hairpin loop binding"], "types": ["T045"], "canonical_name": "RNA stem-loop binding", "definition": "Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. [GOC:sart, PMID:16568238, PMID:20455544]"}
{"concept_id": "C3158796", "aliases": ["small nuclear RNA stem-loop binding", "snRNA hairpin binding", "snRNA hairpin loop binding"], "types": ["T045"], "canonical_name": "snRNA stem-loop binding", "definition": "Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. [GOC:sart, PMID:16568238, PMID:20455544]"}
{"concept_id": "C3158797", "aliases": ["clathrin-associated adaptor activity"], "types": ["T044"], "canonical_name": "clathrin adaptor activity", "definition": "Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. [GOC:BHF, PMID:15728179]"}
{"concept_id": "C3158798", "aliases": [], "types": ["T044"], "canonical_name": "histone H2B conserved C-terminal lysine deubiquitination", "definition": "A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals. [GOC:bf, GOC:vw, PMID:15657442]"}
{"concept_id": "C3158799", "aliases": [], "types": ["T044"], "canonical_name": "budding yeast H2B K123 deubiquitination"}
{"concept_id": "C3158800", "aliases": [], "types": ["T044"], "canonical_name": "fission yeast H2B K119 deubiquitination"}
{"concept_id": "C3158801", "aliases": [], "types": ["T044"], "canonical_name": "mammalian H2B K120 deubiquitination"}
{"concept_id": "C3158802", "aliases": ["SG disassembly"], "types": ["T043"], "canonical_name": "stress granule disassembly", "definition": "The disaggregation of a stress granule into its constituent protein and RNA parts. [GOC:BHF, PMID:19825938]"}
{"concept_id": "C3158803", "aliases": [], "types": ["T026"], "definition": "A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall. [http://www.jstor.org/stable/4354264, PO:0000256]", "canonical_name": "root hair"}
{"concept_id": "C3158804", "aliases": ["root hair cell tip"], "types": ["T026"], "canonical_name": "root hair tip", "definition": "The tip portion of an outgrowth of a root epidermal cell. [PMID:16567499]"}
{"concept_id": "C3158805", "aliases": [], "types": ["T044"], "canonical_name": "ceramide transporter activity"}
{"concept_id": "C3158806", "aliases": ["ER to Golgi ceramide translocation", "endoplasmic reticulum to Golgi ceramide transport", "non-vesicular ceramide trafficking"], "types": ["T043"], "canonical_name": "ER to Golgi ceramide transport", "definition": "The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid. [GOC:sart, PMID:14685229]"}
{"concept_id": "C3158807", "aliases": ["IHBD development", "intrahepatic biliary duct development"], "types": ["T042"], "canonical_name": "intrahepatic bile duct development", "definition": "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). [GOC:bf, PMID:20614624]"}
{"concept_id": "C3158808", "aliases": ["nephron glucose absorption", "glucose reabsorption"], "types": ["T043"], "canonical_name": "renal glucose absorption", "definition": "A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:yaf, PMID:11269503]"}
{"concept_id": "C3158809", "aliases": [], "types": ["T039"], "canonical_name": "receptor transactivation", "definition": "The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer. [GOC:al, GOC:bf, GOC:BHF, PMID:16870826, PMID:21063387]"}
{"concept_id": "C3158811", "aliases": ["juvenile hormone-mediated signaling pathway", "juvenile hormone mediated signalling pathway"], "types": ["T044"], "canonical_name": "juvenile hormone mediated signaling pathway", "definition": "The series of molecular signals initiated by a juvenile hormone binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:sart]"}
{"concept_id": "C3158812", "aliases": [], "types": ["T043"], "canonical_name": "ceramide transport", "definition": "The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid. [GOC:bf, GOC:sart]"}
{"concept_id": "C3158813", "aliases": [], "types": ["T042"], "canonical_name": "cystic duct development", "definition": "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gall bladder to the common bile duct. [PMID:20614624]"}
{"concept_id": "C3158814", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid N-linked glycosylation", "definition": "Addition of a carbohydrate or carbohydrate derivative unit via a nitrogen (N) atom of the N-terminal amino acid of a protein. [GOC:bf, GOC:pr]"}
{"concept_id": "C3158815", "aliases": [], "types": ["T042"], "canonical_name": "bone mineralization involved in bone maturation", "definition": "The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state. [GOC:bf, GOC:BHF]"}
{"concept_id": "C3158816", "aliases": ["CD40 receptor complex location"], "types": ["T026"], "canonical_name": "CD40 receptor complex", "definition": "A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. [GOC:BHF, PMID:20614026, PMID:9221764]"}
{"concept_id": "C3158817", "aliases": ["mitochondrial inner membrane prohibitin complex location", "mitochondrial prohibitin complex location", "mitochondrial inner membrane prohibitin complex"], "types": ["T026"], "canonical_name": "mitochondrial prohibitin complex", "definition": "A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death. [GOC:kmv, PMID:12237468, PMID:21164222]"}
{"concept_id": "C3158818", "aliases": ["maintenance of BBB", "maintenance of blood/brain barrier"], "types": ["T043"], "canonical_name": "maintenance of blood-brain barrier", "definition": "Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation. [GOC:aruk, GOC:bc, GOC:bf, GOC:sl, PMID:20080302, PMID:30280653]"}
{"concept_id": "C3158819", "aliases": [], "types": ["T043"], "canonical_name": "response to stilbenoid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. [GOC:yaf, Wikipedia:Stilbenoid]"}
{"concept_id": "C3158820", "aliases": ["invasion of bacteria into host cell", "bacterial entry into host cell"], "types": ["T046"], "canonical_name": "entry of bacterium into host cell", "definition": "The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:bf, PMID:21187937]"}
{"concept_id": "C3158823", "aliases": ["multicellular organismal signalling"], "types": ["T040"], "canonical_name": "multicellular organismal signaling", "definition": "The transfer of information occurring at the level of a multicellular organism. [GOC:go_curators]"}
{"concept_id": "C3158824", "aliases": [], "types": ["T043"], "canonical_name": "signal maturation"}
{"concept_id": "C3158825", "aliases": [], "types": ["T043"], "canonical_name": "ligand maturation"}
{"concept_id": "C3158826", "aliases": [], "types": ["T044"], "canonical_name": "purine ribonucleoside triphosphate binding", "definition": "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:BHF, GOC:ebc, ISBN:0198506732]"}
{"concept_id": "C3158827", "aliases": [], "types": ["T044"], "canonical_name": "purine NTP binding"}
{"concept_id": "C3158828", "aliases": [], "types": ["T055"], "canonical_name": "locomotory exploration behavior", "definition": "The specific movement from place to place of an organism in response to a novel environment. [GOC:sart, PMID:17151232]"}
{"concept_id": "C3158829", "aliases": ["histone methylase activity (H3-R17 specific)", "histone-arginine N-methyltransferase activity (H3-R17 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-R17 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3. [GOC:sp, PMID:11341840]"}
{"concept_id": "C3158830", "aliases": ["L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity"], "types": ["T044"], "canonical_name": "L-DOPA receptor activity", "definition": "Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine. [PMID:18828673, Wikipedia:L-DOPA]"}
{"concept_id": "C3158831", "aliases": [], "types": ["T044"], "canonical_name": "phosphoanandamide dephosphorylation", "definition": "The process of removing one or more phosphate groups from a phosphorylated anandamide. [GOC:BHF, PMID:16938887]"}
{"concept_id": "C3158832", "aliases": ["intestinal smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "enteric smooth muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. [CL:0002504, GOC:BHF]"}
{"concept_id": "C3158833", "aliases": [], "types": ["T043"], "canonical_name": "endosome to melanosome transport", "definition": "The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle. [PMID:16162817]"}
{"concept_id": "C3158834", "aliases": ["3-oxo-delta4,5-steroid 5beta-reductase"], "types": ["T044"], "canonical_name": "3-oxo-delta(4,5)-steroid 5-beta-reductase activity", "definition": "Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H(+) = a 5-beta-3-oxo-steroid + NADP(+). [GOC:kad, MetaCyc:RXN-9726, PMID:19166903]"}
{"concept_id": "C3158835", "aliases": ["circadian mating behaviour", "circadian mating rhythm"], "types": ["T053"], "canonical_name": "circadian mating behavior", "definition": "The fluctuation in mating behavior that occurs over an approximately 24 hour cycle. [GOC:bf, GOC:dos, PMID:11470898, PMID:17276917]"}
{"concept_id": "C3158836", "aliases": ["Nrd1 complex location"], "types": ["T026"], "canonical_name": "Nrd1 complex", "definition": "A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p. [GOC:jh, PMID:10655211, PMID:16427013, PMID:21084293]"}
{"concept_id": "C3158837", "aliases": [], "types": ["T044"], "canonical_name": "AP-1 adaptor complex binding", "definition": "Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). [PMID:21097499]"}
{"concept_id": "C3158838", "aliases": [], "types": ["T044"], "canonical_name": "AP-3 adaptor complex binding", "definition": "Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). [PMID:21097499]"}
{"concept_id": "C3158839", "aliases": ["cargo loading into clathrin-coated vesicle"], "types": ["T044"], "canonical_name": "clathrin-coated vesicle cargo loading", "definition": "Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle. [GOC:lb, PMID:16162817]"}
{"concept_id": "C3158840", "aliases": ["cargo loading into clathrin-coated vesicle, AP-1-mediated"], "types": ["T044"], "canonical_name": "clathrin-coated vesicle cargo loading, AP-1-mediated", "definition": "Formation of a macromolecular complex between proteins of the AP-1 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking. [GOC:lb, PMID:12802059, PMID:16162817]"}
{"concept_id": "C3158841", "aliases": ["cargo loading into clathrin-coated vesicle, AP-3-mediated"], "types": ["T044"], "canonical_name": "clathrin-coated vesicle cargo loading, AP-3-mediated", "definition": "Formation of a macromolecular complex between proteins of the AP-3 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. In some cases, the AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle. [GOC:lb, PMID:12802059, PMID:16162817]"}
{"concept_id": "C3158842", "aliases": ["interleukin-18-mediated signalling pathway"], "types": ["T043"], "canonical_name": "interleukin-18-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:BHF, GOC:signaling]"}
{"concept_id": "C3158844", "aliases": ["eRF1 MTase complex", "eRF1 MTase complex location", "eRF1 methyltransferase complex location"], "types": ["T026"], "canonical_name": "eRF1 methyltransferase complex", "definition": "A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p. [GOC:rb, PMID:17008308, PMID:20400505]"}
{"concept_id": "C3158845", "aliases": ["Mon1-Ccz1 complex location"], "types": ["T026"], "canonical_name": "Mon1-Ccz1 complex", "definition": "A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p. [GOC:rb, PMID:20797862]"}
{"concept_id": "C3158846", "aliases": ["Wnt-activated signaling pathway involved in wound healing, spreading of epidermal cells", "Wnt receptor signalling pathway involved in wound healing, spreading of epidermal cells", "Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in wound healing, spreading of epidermal cells", "definition": "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis. [GOC:BHF]"}
{"concept_id": "C3158847", "aliases": ["MyD88-dependent toll-like receptor 4 signalling pathway", "MyD88-dependent TLR4 signaling pathway"], "types": ["T044"], "canonical_name": "MyD88-dependent toll-like receptor 4 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. [GOC:BHF, PMID:18304834, PMID:20385024]"}
{"concept_id": "C3158848", "aliases": ["MyD88-dependent toll-like receptor 2 signalling pathway", "MyD88-dependent TLR2 signaling pathway"], "types": ["T044"], "canonical_name": "MyD88-dependent toll-like receptor 2 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response. [GOC:BHF, PMID:20385024]"}
{"concept_id": "C3158849", "aliases": ["TLR4 binding"], "types": ["T044"], "canonical_name": "Toll-like receptor 4 binding", "definition": "Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. [GOC:BHF, PMID:18304834]"}
{"concept_id": "C3158850", "aliases": ["TLR2 binding"], "types": ["T044"], "canonical_name": "Toll-like receptor 2 binding", "definition": "Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response. [GOC:BHF]"}
{"concept_id": "C3158851", "aliases": ["MyD88 adapter-like dependent toll-like receptor signaling pathway", "TIRAP-dependent toll-like receptor signalling pathway", "TIRAP-dependent TLR signaling pathway", "MAL-dependent toll-like receptor signaling pathway"], "types": ["T044"], "canonical_name": "TIRAP-dependent toll-like receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GOC:BHF, PMID:11526399, PMID:11544529, PMID:12447442]"}
{"concept_id": "C3158852", "aliases": ["MAL-dependent toll-like receptor 4 signaling pathway", "MyD88 adapter-like dependent toll-like receptor 4 signaling pathway", "TIRAP-dependent toll-like receptor 4 signalling pathway", "TIRAP-dependent TLR4 signaling pathway"], "types": ["T044"], "canonical_name": "TIRAP-dependent toll-like receptor 4 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. [GOC:BHF, PMID:12447441]"}
{"concept_id": "C3158853", "aliases": ["Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway", "TRIF-dependent toll-like receptor signalling pathway", "TRIF-dependent TLR signaling pathway"], "types": ["T044"], "canonical_name": "TRIF-dependent toll-like receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GOC:BHF, PMID:12855817]"}
{"concept_id": "C3158854", "aliases": ["Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR4 signaling pathway", "TRIF-dependent toll-like receptor 4 signalling pathway", "TRIF-dependent TLR4 signaling pathway"], "types": ["T044"], "canonical_name": "TRIF-dependent toll-like receptor 4 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. [GOC:BHF, PMID:18641322, PMID:20511708]"}
{"concept_id": "C3158855", "aliases": ["TRAM-dependent toll-like receptor signalling pathway", "TRAM-dependent TLR signaling pathway"], "types": ["T044"], "canonical_name": "TRAM-dependent toll-like receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GOC:BHF, PMID:14556004]"}
{"concept_id": "C3158856", "aliases": ["TRAM-dependent TLR4 signaling pathway", "TRAM-dependent toll-like receptor 4 signalling pathway"], "types": ["T044"], "canonical_name": "TRAM-dependent toll-like receptor 4 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. [GOC:BHF, PMID:14556004, PMID:18297073]"}
{"concept_id": "C3158858", "aliases": [], "types": ["T044"], "canonical_name": "enone reductase activity", "definition": "Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+. [EC:1.3.1.-, GOC:kad, PMID:17945329, PMID:19166903]"}
{"concept_id": "C3158859", "aliases": ["oligopeptide membrane transport"], "types": ["T043"], "canonical_name": "oligopeptide transmembrane transport", "definition": "The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [GOC:vw, ISBN:0198506732]"}
{"concept_id": "C3158860", "aliases": [], "types": ["T044"], "canonical_name": "oligopeptide transmembrane transporter activity", "definition": "Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [GOC:vw, ISBN:0198506732]"}
{"concept_id": "C3158861", "aliases": ["tricarboxylic acid membrane transport"], "types": ["T043"], "canonical_name": "tricarboxylic acid transmembrane transport", "definition": "The process in which a tricarboxylic acid is transported across a membrane. [GOC:vw]"}
{"concept_id": "C3158862", "aliases": [], "types": ["T043"], "canonical_name": "neuromast hair cell development", "definition": "The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. [CL:0000856]"}
{"concept_id": "C3158863", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line neuromast hair cell development", "definition": "The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. [ISBN:0125296509, ISBN:0387968377]"}
{"concept_id": "C3158864", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line neuromast hair cell development", "definition": "The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. [ISBN:0125296509]"}
{"concept_id": "C3158865", "aliases": [], "types": ["T043"], "canonical_name": "neuromast hair cell morphogenesis", "definition": "The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. [CL:0000856]"}
{"concept_id": "C3158866", "aliases": [], "types": ["T043"], "canonical_name": "anterior lateral line neuromast hair cell morphogenesis", "definition": "The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. [ISBN:0125296509, ISBN:0387968377]"}
{"concept_id": "C3158867", "aliases": [], "types": ["T043"], "canonical_name": "posterior lateral line neuromast hair cell morphogenesis", "definition": "The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. [ISBN:0125296509]"}
{"concept_id": "C3158868", "aliases": ["toll-like receptor 15 signalling pathway", "TLR15 signaling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 15 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 15. [GOC:pde]"}
{"concept_id": "C3158869", "aliases": ["toll-like receptor 21 signalling pathway", "TLR21 signaling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor 21 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to toll-like receptor 21. [GOC:pde]"}
{"concept_id": "C3158870", "aliases": ["memory T-cell extravasation"], "types": ["T043"], "canonical_name": "memory T cell extravasation", "definition": "The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive. [CL:0000813, GOC:BHF]"}
{"concept_id": "C3158871", "aliases": ["helper T-cell extravasation", "T-helper cell extravasation"], "types": ["T043"], "canonical_name": "helper T cell extravasation", "definition": "The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells. [CL:0000912, GOC:BHF]"}
{"concept_id": "C3158872", "aliases": ["helper T-cell diapedesis", "T-helper cell diapedesis"], "types": ["T043"], "canonical_name": "helper T cell diapedesis", "definition": "The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. [CL:0000912, GOC:BHF]"}
{"concept_id": "C3158873", "aliases": ["flagellum fibrous sheath", "flagellar fibrous sheath"], "types": ["T026"], "canonical_name": "sperm fibrous sheath", "definition": "A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat. [GOC:BHF, GOC:cilia, GOC:krc, PMID:20731842, PMID:3282552]"}
{"concept_id": "C3158874", "aliases": ["Th1 cell extravasation"], "types": ["T043"], "canonical_name": "T-helper 1 cell extravasation", "definition": "The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. [CL:0000545, GOC:BHF]"}
{"concept_id": "C3158875", "aliases": ["Th1 cell diapedesis"], "types": ["T043"], "canonical_name": "T-helper 1 cell diapedesis", "definition": "The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. [CL:0000545, GOC:BHF, PMID:10477596]"}
{"concept_id": "C3158876", "aliases": ["RANTES-mediated signaling pathway", "CCL5-mediated signaling pathway", "chemokine (C-C motif) ligand 5 signalling pathway"], "types": ["T043"], "canonical_name": "chemokine (C-C motif) ligand 5 signaling pathway", "definition": "The series of molecular signals initiated by chemokine CCL5 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, PMID:18337562]"}
{"concept_id": "C3158878", "aliases": ["MIF signaling pathway", "macrophage migration inhibitory factor signalling pathway"], "types": ["T043"], "canonical_name": "macrophage migration inhibitory factor signaling pathway", "definition": "The series of molecular signals initiated by macrophage migration inhibitory factor binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling, PMID:12782713, PMID:19413900]"}
{"concept_id": "C3158879", "aliases": ["macrophage migration inhibitory factor receptor complex location"], "types": ["T026"], "canonical_name": "macrophage migration inhibitory factor receptor complex", "definition": "A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins. [GOC:BHF, PMID:12782713, PMID:17045821]"}
{"concept_id": "C3158880", "aliases": ["NOS2-CD74 complex location"], "types": ["T026"], "canonical_name": "NOS2-CD74 complex", "definition": "A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases. [GOC:BHF, PMID:18003616]"}
{"concept_id": "C3158881", "aliases": ["catabolism of mitochondrial protein", "degradation of damaged mitochondrial protein"], "types": ["T043"], "canonical_name": "mitochondrial protein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure. [GOC:sp, PMID:21264221, PMID:21264228]"}
{"concept_id": "C3158882", "aliases": [], "types": ["T043"], "canonical_name": "mitophagy by induced vacuole formation", "definition": "The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes. [GOC:autophagy, GOC:bf, GOC:sp, PMID:21264228]"}
{"concept_id": "C3158883", "aliases": [], "types": ["T043"], "canonical_name": "MIV-mediated mitophagy"}
{"concept_id": "C3158884", "aliases": [], "types": ["T043"], "canonical_name": "monocyte extravasation", "definition": "The migration of a monocyte from the blood vessels into the surrounding tissue. [CL:0000576, GOC:BHF, PMID:10657654]"}
{"concept_id": "C3158885", "aliases": [], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta T cell extravasation", "definition": "The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue. [CL:0000625, GOC:BHF]"}
{"concept_id": "C3158886", "aliases": [], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta cytotoxic T cell extravasation", "definition": "The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue. [CL:0000794, GOC:BHF]"}
{"concept_id": "C3158887", "aliases": [], "types": ["T043"], "canonical_name": "T-helper 17 cell extravasation", "definition": "The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue. [CL:0000899, GOC:BHF]"}
{"concept_id": "C3158888", "aliases": [], "types": ["T043"], "canonical_name": "astrocyte chemotaxis", "definition": "The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [CL:0000127, GOC:BHF, PMID:12271471]"}
{"concept_id": "C3158889", "aliases": ["hemopoietic stem cell migration"], "types": ["T043"], "canonical_name": "hematopoietic stem cell migration", "definition": "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. [CL:0000037, GOC:BHF, PMID:20234092]"}
{"concept_id": "C3158890", "aliases": [], "types": ["T043"], "canonical_name": "monocyte homeostasis", "definition": "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. [CL:0000576, GOC:BHF, PMID:18832716]"}
{"concept_id": "C3158891", "aliases": ["release of monocytes into circulation"], "types": ["T043"], "canonical_name": "monocyte migration into blood stream", "definition": "The movement of a monocyte from the bone marrow to the blood stream. [CL:0000576, GOC:BHF]"}
{"concept_id": "C3158892", "aliases": ["T-helper cell chemotaxis"], "types": ["T043"], "canonical_name": "helper T cell chemotaxis", "definition": "The directed movement of a helper T cell in response to an external stimulus. [CL:0000912, GOC:BHF]"}
{"concept_id": "C3158893", "aliases": ["Th17 cell chemotaxis"], "types": ["T043"], "canonical_name": "T-helper 17 cell chemotaxis", "definition": "The directed movement of a T-helper 17 cell in response to an external stimulus. [CL:0000899, GOC:BHF]"}
{"concept_id": "C3158894", "aliases": ["Th1 cell chemotaxis"], "types": ["T043"], "canonical_name": "T-helper 1 cell chemotaxis", "definition": "The directed movement of a T-helper 1 cell in response to an external stimulus. [CL:0000545, GOC:BHF]"}
{"concept_id": "C3158895", "aliases": ["Th2 cell chemotaxis"], "types": ["T043"], "canonical_name": "T-helper 2 cell chemotaxis", "definition": "The directed movement of a T-helper 2 cell in response to an external stimulus. [CL:0000546, GOC:BHF]"}
{"concept_id": "C3158896", "aliases": ["IL-4-dependent isotype switching to IgE isotypes"], "types": ["T045"], "canonical_name": "interleukin-4-dependent isotype switching to IgE isotypes", "definition": "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4). [GOC:BHF, PMID:12496423]"}
{"concept_id": "C3158897", "aliases": [], "types": ["T043"], "canonical_name": "memory T cell activation", "definition": "The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [CL:0000813, GOC:BHF]"}
{"concept_id": "C3158898", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta T cell activation", "definition": "The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [CL:0000624, GOC:BHF]"}
{"concept_id": "C3158899", "aliases": ["Th1 cell activation"], "types": ["T043"], "canonical_name": "T-helper 1 cell activation", "definition": "The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [CL:0000545, GOC:BHF]"}
{"concept_id": "C3158900", "aliases": ["Th2 cell activation"], "types": ["T043"], "canonical_name": "T-helper 2 cell activation", "definition": "The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [CL:0000546, GOC:BHF]"}
{"concept_id": "C3158901", "aliases": ["response to NO2"], "types": ["T043"], "canonical_name": "response to nitrogen dioxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus. [GOC:BHF]"}
{"concept_id": "C3158902", "aliases": ["cellular response to NO2"], "types": ["T043"], "canonical_name": "cellular response to nitrogen dioxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus. [GOC:BHF]"}
{"concept_id": "C3158903", "aliases": ["CCL2 binding"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 2 binding", "definition": "Binding to chemokine (C-C motif) ligand 2. [GOC:BHF]"}
{"concept_id": "C3158904", "aliases": ["CCL12 binding"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 12 binding", "definition": "Binding to chemokine (C-C motif) ligand 12. [GOC:BHF]"}
{"concept_id": "C3158905", "aliases": ["CCL7 binding"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 7 binding", "definition": "Binding to chemokine (C-C motif) ligand 7. [GOC:BHF]"}
{"concept_id": "C3158906", "aliases": ["MIF binding"], "types": ["T044"], "canonical_name": "macrophage migration inhibitory factor binding", "definition": "Binding to the cytokine, macrophage migration inhibitory factor. [GOC:BHF, PMID:19601712]"}
{"concept_id": "C3158907", "aliases": ["tRNA nuclear import", "retrograde tRNA transport into nucleus"], "types": ["T043"], "canonical_name": "tRNA import into nucleus", "definition": "The directed movement of tRNA from the cytoplasm to the nucleus. [GOC:vw, PMID:20032305]"}
{"concept_id": "C3158908", "aliases": ["intraflagellar anterograde transport"], "types": ["T043"], "canonical_name": "intraciliary anterograde transport", "definition": "The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins. [GOC:BHF, GOC:cilia, PMID:17895364]"}
{"concept_id": "C3158909", "aliases": ["intraflagellar retrograde transport"], "types": ["T043"], "canonical_name": "intraciliary retrograde transport", "definition": "The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins. [GOC:BHF, GOC:cilia]"}
{"concept_id": "C3158910", "aliases": ["IL-12-mediated signaling pathway", "interleukin-12-mediated signalling pathway"], "types": ["T043"], "canonical_name": "interleukin-12-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling]"}
{"concept_id": "C3158911", "aliases": ["IL-15-mediated signaling pathway", "interleukin-15-mediated signalling pathway"], "types": ["T043"], "canonical_name": "interleukin-15-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-15 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling]"}
{"concept_id": "C3158912", "aliases": ["CD24 anabolism", "CD24 synthesis", "CD24 biosynthesis", "CD24 formation"], "types": ["T044"], "canonical_name": "CD24 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation. [GOC:BHF]"}
{"concept_id": "C3158913", "aliases": ["sodium ion membrane transport"], "types": ["T044"], "canonical_name": "sodium ion transmembrane transport", "definition": "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]"}
{"concept_id": "C3158914", "aliases": [], "types": ["T043"], "canonical_name": "common myeloid progenitor cell proliferation", "definition": "The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage. [CL:0000049, GOC:BHF]"}
{"concept_id": "C3158915", "aliases": ["LPA binding"], "types": ["T044"], "canonical_name": "lysophosphatidic acid binding", "definition": "Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors. [GOC:curators]"}
{"concept_id": "C3158916", "aliases": ["response to HGF stimulus", "response to hepatocyte growth factor stimulus"], "types": ["T043"], "canonical_name": "response to hepatocyte growth factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. [GOC:bf]"}
{"concept_id": "C3158917", "aliases": ["cellular response to HGF stimulus"], "types": ["T043"], "canonical_name": "cellular response to hepatocyte growth factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. [GOC:bf]"}
{"concept_id": "C3158918", "aliases": ["GSNO binding"], "types": ["T044"], "canonical_name": "S-nitrosoglutathione binding", "definition": "Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems. [GOC:BHF]"}
{"concept_id": "C3158919", "aliases": ["dinitrosyl-diglutathionyl-iron complex binding", "DNDGIC binding", "DNIC binding"], "types": ["T044"], "canonical_name": "dinitrosyl-iron complex binding", "definition": "Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO. [GOC:BHF, PMID:10534443]"}
{"concept_id": "C3158920", "aliases": ["NO storage"], "types": ["T038"], "canonical_name": "nitric oxide storage", "definition": "The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins. [GOC:BHF, PMID:12871945]"}
{"concept_id": "C3158921", "aliases": [], "types": ["T043"], "canonical_name": "hepatic stellate cell activation", "definition": "A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor. [CL:0000632, GOC:bf]"}
{"concept_id": "C3158923", "aliases": ["intraflagellar transport involved in cilium morphogenesis"], "types": ["T043"], "canonical_name": "intraciliary transport involved in cilium morphogenesis"}
{"concept_id": "C3158924", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in compound eye morphogenesis", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. [GOC:bf, GOC:sart]"}
{"concept_id": "C3158926", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta T cell proliferation", "definition": "The expansion of a CD4-positive, alpha-beta T cell population by cell division. [CL:0000624, GOC:BHF]"}
{"concept_id": "C3158927", "aliases": [], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta T cell proliferation", "definition": "The expansion of a CD8-positive, alpha-beta T cell population by cell division. [CL:0000625, GOC:BHF]"}
{"concept_id": "C3158928", "aliases": [], "types": ["T043"], "canonical_name": "activated CD4-positive, alpha-beta T cell proliferation", "definition": "The expansion of an activated CD4-positive, alpha-beta T cell population by cell division. [CL:0000896, GOC:BHF]"}
{"concept_id": "C3158929", "aliases": [], "types": ["T043"], "canonical_name": "activated CD8-positive, alpha-beta T cell proliferation", "definition": "The expansion of an activated CD8-positive, alpha-beta T cell population by cell division. [CL:0000906, GOC:BHF]"}
{"concept_id": "C3158930", "aliases": [], "types": ["T040"], "canonical_name": "CD4-positive, alpha-beta T cell cytokine production", "definition": "Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell. [CL:0000624, GOC:BHF]"}
{"concept_id": "C3158931", "aliases": ["Th1 cell cytokine production"], "types": ["T040"], "canonical_name": "T-helper 1 cell cytokine production", "definition": "Any process that contributes to cytokine production by a T-helper 1 cell. [CL:0000545, GOC:BHF]"}
{"concept_id": "C3158932", "aliases": ["Th2 cell cytokine production"], "types": ["T040"], "canonical_name": "T-helper 2 cell cytokine production", "definition": "Any process that contributes to cytokine production by a T-helper 2 cell. [CL:0000546, GOC:BHF]"}
{"concept_id": "C3158933", "aliases": [], "types": ["T038"], "canonical_name": "granzyme A production", "definition": "The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]"}
{"concept_id": "C3158934", "aliases": [], "types": ["T043"], "canonical_name": "natural killer cell chemotaxis", "definition": "The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [CL:0000623, GOC:BHF]"}
{"concept_id": "C3158935", "aliases": [], "types": ["T026"], "canonical_name": "myelin sheath abaxonal region", "definition": "The region of the myelin sheath furthest from the axon. [GOC:BHF, PMID:20237282]"}
{"concept_id": "C3158936", "aliases": [], "types": ["T026"], "canonical_name": "myelin sheath adaxonal region", "definition": "The region of the myelin sheath nearest to the axon. [GOC:BHF, PMID:20237282]"}
{"concept_id": "C3158937", "aliases": ["protein localisation to myelin sheath abaxonal region"], "types": ["T043"], "canonical_name": "protein localization to myelin sheath abaxonal region", "definition": "Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon. [GOC:BHF, PMID:20237282]"}
{"concept_id": "C3158938", "aliases": [], "types": ["T040"], "canonical_name": "regulation of lysosomal lumen pH", "definition": "Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. [GOC:rph]"}
{"concept_id": "C3158939", "aliases": ["lysosome pH elevation"], "types": ["T043"], "canonical_name": "lysosomal lumen pH elevation", "definition": "Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. [GOC:bf, GOC:rph]"}
{"concept_id": "C3158940", "aliases": [], "types": ["T045"], "canonical_name": "maintenance of DNA trinucleotide repeats", "definition": "Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs. [GOC:rb, PMID:21347277, SO:0000291]"}
{"concept_id": "C3158941", "aliases": [], "types": ["T043"], "canonical_name": "B cell chemotaxis", "definition": "The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [CL:0000236, GOC:BHF]"}
{"concept_id": "C3158942", "aliases": [], "types": ["T044"], "canonical_name": "cardiolipin hydrolase activity", "definition": "Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA). [GOC:sp, PMID:17028579, PMID:21397848]"}
{"concept_id": "C3158943", "aliases": ["migration of symbiont within host by transepithelial trafficking", "migration in host through an epithelial cell layer"], "types": ["T040"], "canonical_name": "transepithelial migration of symbiont in host", "definition": "The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:bf, PMID:10639460]"}
{"concept_id": "C3158944", "aliases": ["CCL19 binding"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 19 binding", "definition": "Binding to chemokine (C-C motif) ligand 19. [GOC:BHF]"}
{"concept_id": "C3158945", "aliases": ["CCL21 binding"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 21 binding", "definition": "Binding to chemokine (C-C motif) ligand 21. [GOC:BHF]"}
{"concept_id": "C3158946", "aliases": [], "types": ["T026"], "canonical_name": "mesangial cell-matrix adhesion", "definition": "The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney. [CL:0000650, GOC:BHF, PMID:15569314]"}
{"concept_id": "C3158947", "aliases": [], "types": ["T045"], "canonical_name": "cytoplasmic polyadenylation-dependent rRNA catabolic process", "definition": "The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate. [PMID:20368444]"}
{"concept_id": "C3158948", "aliases": [], "types": ["T042"], "canonical_name": "dorsal motor nucleus of vagus nerve maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state. [GOC:dgh]"}
{"concept_id": "C3158949", "aliases": [], "types": ["T040"], "canonical_name": "dorsal motor nucleus of vagus nerve morphogenesis", "definition": "The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form. [GOC:dgh]"}
{"concept_id": "C3158950", "aliases": ["dorsal motor nucleus of vagus nerve structural organisation"], "types": ["T042"], "canonical_name": "dorsal motor nucleus of vagus nerve structural organization", "definition": "The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. [GOC:dgh]"}
{"concept_id": "C3158951", "aliases": [], "types": ["T042"], "canonical_name": "dorsal motor nucleus of vagus nerve formation", "definition": "The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. [GOC:dgh]"}
{"concept_id": "C3158952", "aliases": [], "types": ["T043"], "canonical_name": "motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation", "definition": "The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve. [GOC:dgh, PMID:21262462]"}
{"concept_id": "C3158953", "aliases": [], "types": ["T043"], "canonical_name": "cell chemotaxis to fibroblast growth factor", "definition": "The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF). [GOC:BHF]"}
{"concept_id": "C3158954", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell chemotaxis", "definition": "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [CL:0000115, GOC:BHF]"}
{"concept_id": "C3158955", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell chemotaxis to fibroblast growth factor", "definition": "The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF). [CL:0000115, GOC:BHF]"}
{"concept_id": "C3158956", "aliases": ["B-cell chemotaxis across high endothelial venule"], "types": ["T043"], "canonical_name": "B cell chemotaxis across high endothelial venule", "definition": "The movement of a B cell to cross a high endothelial venule in response to an external stimulus. [CL:0000236, GOC:BHF]"}
{"concept_id": "C3158958", "aliases": ["interleukin-4-mediated signalling pathway", "IL-4-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-4-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-4 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling]"}
{"concept_id": "C3158959", "aliases": ["interleukin-13-mediated signalling pathway", "IL-13-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-13-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-13 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling]"}
{"concept_id": "C3158960", "aliases": ["insulin secretion involved in cellular response to glucose"], "types": ["T043"], "canonical_name": "insulin secretion involved in cellular response to glucose stimulus", "definition": "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. [GOC:bf, GOC:yaf, PMID:8492079]"}
{"concept_id": "C3158961", "aliases": ["positive regulation of insulin secretion in response to glucose"], "types": ["T043"], "canonical_name": "positive regulation of insulin secretion involved in cellular response to glucose stimulus", "definition": "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:bf, GOC:yaf]"}
{"concept_id": "C3158962", "aliases": [], "types": ["T042"], "canonical_name": "pronephric glomerulus morphogenesis", "definition": "The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment. [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]"}
{"concept_id": "C3158963", "aliases": [], "types": ["T042"], "canonical_name": "pronephric proximal tubule development", "definition": "The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]"}
{"concept_id": "C3158964", "aliases": [], "types": ["T042"], "canonical_name": "pronephric distal tubule development", "definition": "The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]"}
{"concept_id": "C3158965", "aliases": [], "types": ["T043"], "canonical_name": "pronephric nephron tubule epithelial cell differentiation", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]"}
{"concept_id": "C3158966", "aliases": ["angioblastic mesenchymal cell differentiation"], "types": ["T043"], "canonical_name": "angioblast cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). [CL:0000566, GOC:yaf]"}
{"concept_id": "C3158967", "aliases": ["CD80 biosynthesis", "CD80 anabolism", "CD80 synthesis", "CD80 formation"], "types": ["T044"], "canonical_name": "CD80 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival. [GOC:BHF, GOC:ebc]"}
{"concept_id": "C3158968", "aliases": ["CD86 synthesis", "CD86 formation", "CD86 anabolism", "CD86 biosynthesis"], "types": ["T044"], "canonical_name": "CD86 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival. [GOC:BHF, GOC:ebc]"}
{"concept_id": "C3158969", "aliases": ["activated natural killer cell chemotaxis"], "types": ["T043"], "canonical_name": "mature natural killer cell chemotaxis", "definition": "The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules. [CL:0000824, GOC:BHF]"}
{"concept_id": "C3158970", "aliases": ["CD4-positive, alpha beta T cell costimulation"], "types": ["T043"], "canonical_name": "CD4-positive, alpha-beta T cell costimulation", "definition": "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation. [CL:0000624, GOC:BHF, GOC:pr]"}
{"concept_id": "C3158971", "aliases": ["cellular nickel homeostasis"], "types": ["T043"], "canonical_name": "cellular nickel ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of nickel ions at the level of a cell. [GOC:kmv]"}
{"concept_id": "C3158973", "aliases": [], "types": ["T043"], "canonical_name": "cell migration involved in kidney development", "definition": "The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ. [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf]"}
{"concept_id": "C3158974", "aliases": ["cell migration involved in metanephric kidney development"], "types": ["T043"], "canonical_name": "cell migration involved in metanephros development", "definition": "The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ. [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf]"}
{"concept_id": "C3158975", "aliases": [], "types": ["T043"], "canonical_name": "metanephric mesenchymal cell migration", "definition": "The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros. [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101, PMID:19019919]"}
{"concept_id": "C3158976", "aliases": [], "types": ["T043"], "canonical_name": "metanephric mesenchyme chemotaxis"}
{"concept_id": "C3158977", "aliases": ["alphaPDGF receptor signaling pathway", "PDGF receptor-alpha signaling pathway", "platelet-derived growth factor receptor-alpha signalling pathway"], "types": ["T044"], "canonical_name": "platelet-derived growth factor receptor-alpha signaling pathway", "definition": "The series of molecular signals initiated a ligand binding to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:yaf, PMID:10372961]"}
{"concept_id": "C3158978", "aliases": ["other organism postsynaptic membrane", "other organism post-synaptic membrane"], "types": ["T026"], "canonical_name": "host cell postsynaptic membrane", "definition": "A postsynaptic membrane that is part of a host cell. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane. [GOC:ecd]"}
{"concept_id": "C3158979", "aliases": ["positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway", "positive regulation of metanephric mesenchymal cell migration by betaPDGF receptor signaling pathway", "positive regulation of metanephric mesenchymal cell migration by PDGF receptor-beta signaling pathway", "positive regulation of metanephric mesenchymal cell migration by PDGFR-beta signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway", "definition": "Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration resulting from the platelet-derived growth factor receptor-beta signaling pathway. [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101]"}
{"concept_id": "C3158980", "aliases": ["positive regulation of mitochondrial membrane permeability", "MPT"], "types": ["T043"], "definition": "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. [GOC:bf, PMID:12546810]", "canonical_name": "positive regulation of transport across mitochondrial membrane"}
{"concept_id": "C3158981", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition"}
{"concept_id": "C3158982", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization"}
{"concept_id": "C3158983", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition"}
{"concept_id": "C3158984", "aliases": ["negative regulation of transport across mitochondrial membrane"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial membrane permeability", "definition": "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. [PMID:10781072]"}
{"concept_id": "C3158985", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeability"}
{"concept_id": "C3158986", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeabilization"}
{"concept_id": "C3158987", "aliases": ["ATP-binding cassette (ABC) transporter complex location, ECF-type", "energy coupling factor (ECF)-type ABC transporter", "energy-coupling factor transporter", "ATP-binding cassette (ABC) transporter complex, ECF-type", "ATP-binding cassette (ABC) transporter complex location, transmembrane substrate-binding subunit-containing"], "types": ["T026"], "canonical_name": "ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing", "definition": "A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP. [PMID:18931129, PMID:20972419, PMID:21135102]"}
{"concept_id": "C3158988", "aliases": ["SAM-dependent tellurite methyltransferase activity", "S-adenosyl-L-methionine-dependent tellurite methyltransferase activity"], "types": ["T044"], "canonical_name": "tellurite methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride). [GOC:bf, GOC:kad, PMID:11053398, PMID:21244361]"}
{"concept_id": "C3158989", "aliases": [], "types": ["T044"], "canonical_name": "tellurite methylase activity"}
{"concept_id": "C3158990", "aliases": [], "types": ["T042"], "canonical_name": "ureter maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:17881463]"}
{"concept_id": "C3158991", "aliases": [], "types": ["T044"], "canonical_name": "deubiquitinase activator activity", "definition": "Binds to and increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences. [GOC:sart, ISBN:0120793709]"}
{"concept_id": "C3158992", "aliases": ["adrenal gland cortex development"], "types": ["T042"], "canonical_name": "adrenal cortex development", "definition": "The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens). [PMID:12185666, PMID:21115154, Wikipedia:Adrenal_cortex]"}
{"concept_id": "C3158993", "aliases": ["adrenal gland cortex formation"], "types": ["T042"], "canonical_name": "adrenal cortex formation", "definition": "The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate). [PMID:12185666, PMID:21115154]"}
{"concept_id": "C3158994", "aliases": [], "types": ["T043"], "canonical_name": "egg coat formation", "definition": "Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. [GOC:bf, GOC:sart, GOC:yaf, PMID:16944418, PMID:17163408]"}
{"concept_id": "C3158995", "aliases": [], "types": ["T043"], "canonical_name": "VE formation"}
{"concept_id": "C3158996", "aliases": [], "types": ["T043"], "canonical_name": "vitelline envelope formation"}
{"concept_id": "C3158997", "aliases": [], "types": ["T043"], "canonical_name": "zona pellucida assembly"}
{"concept_id": "C3158998", "aliases": [], "types": ["T043"], "canonical_name": "ZP assembly"}
{"concept_id": "C3158999", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of egg coat", "definition": "The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. [PMID:16944418, PMID:17163408]"}
{"concept_id": "C3159000", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of vitelline envelope"}
{"concept_id": "C3159001", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of zona pellucida"}
{"concept_id": "C3159002", "aliases": [], "types": ["T026"], "canonical_name": "egg coat", "definition": "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. [PMID:16944418, PMID:17163408]"}
{"concept_id": "C3159003", "aliases": ["modulation by organism of blood clotting in other organism", "regulation by organism of blood clotting in other organism", "regulation of blood clotting in other organism", "modulation by organism of blood coagulation in other organism", "regulation of blood coagulation in other organism", "modulation of blood coagulation in other organism"], "types": ["T040"], "canonical_name": "modulation of blood coagulation in another organism", "definition": "Any process in which an organism modulates the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. [GOC:bf, GOC:fj]"}
{"concept_id": "C3159004", "aliases": ["positive regulation of blood clotting in other organism", "positive regulation by organism of blood coagulation in other organism", "positive regulation of blood coagulation in other organism", "positive regulation by organism of blood clotting in other organism"], "types": ["T040"], "canonical_name": "positive regulation of blood coagulation in another organism", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. [GOC:bf, GOC:fj, PMID:12362232]"}
{"concept_id": "C3159005", "aliases": ["meiotic recombination initiation complex location"], "types": ["T026"], "canonical_name": "meiotic recombination initiation complex", "definition": "A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins. [GOC:vw, PMID:12897161, PMID:20364342, PMID:21429938]"}
{"concept_id": "C3159006", "aliases": ["regulation of urinary volume", "regulation of urine flow"], "types": ["T039"], "canonical_name": "regulation of urine volume", "definition": "Any process that modulates the amount of urine excreted from the body over a unit of time. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159007", "aliases": ["increase in urine flow", "elevation of urinary volume"], "types": ["T039"], "canonical_name": "positive regulation of urine volume", "definition": "Any process that increases the amount of urine excreted from the body over a unit of time. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159008", "aliases": ["reduction of urinary volume", "decrease in urine flow", "antidiuresis"], "types": ["T039"], "definition": "Any process that decreases the amount of urine excreted from the body over a unit of time. [GOC:mtg_25march11, GOC:yaf]", "canonical_name": "negative regulation of urine volume"}
{"concept_id": "C3159009", "aliases": [], "types": ["T039"], "canonical_name": "renal sodium excretion", "definition": "The elimination of sodium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. [GOC:mtg_25march11, GOC:yaf, PMID:25287933]"}
{"concept_id": "C3159010", "aliases": [], "types": ["T038"], "canonical_name": "regulation of renal sodium excretion", "definition": "Any process that modulates the amount of sodium excreted in urine over a unit of time. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159011", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of renal sodium excretion", "definition": "Any process that decreases the amount of sodium excreted in urine over a unit of time. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159012", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of renal sodium excretion", "definition": "Any process that increases the amount of sodium excreted in urine over a unit of time. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159013", "aliases": [], "types": ["T039"], "canonical_name": "renal water absorption involved in negative regulation of urine volume", "definition": "Any process where water is taken up from the collecting ducts and proximal and distal loops of the nephron, which acts to decrease the amount of urine that is excreted from the body per unit time. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159014", "aliases": [], "types": ["T039"], "canonical_name": "renal sodium ion absorption involved in negative regulation of renal sodium excretion", "definition": "Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159015", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of urine volume by pressure natriuresis", "definition": "An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159016", "aliases": [], "types": ["T039"], "canonical_name": "diuresis resulting from pressure natriuresis"}
{"concept_id": "C3159017", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of renal sodium excretion by pressure natriuresis", "definition": "An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159018", "aliases": [], "types": ["T039"], "canonical_name": "natriuresis resulting from pressure natriuresis"}
{"concept_id": "C3159019", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of renal sodium excretion by angiotensin", "definition": "The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time. [GOC:mtg_25march11, GOC:yaf]"}
{"concept_id": "C3159020", "aliases": ["modification of morphology or physiology of other organism", "modulation of process of other organism"], "types": ["T038"], "canonical_name": "modulation of process of another organism", "definition": "The process in which an organism effects a change in the structure or processes of another organism. [GOC:bf]"}
{"concept_id": "C3159021", "aliases": [], "types": ["T054"], "canonical_name": "regulation of morphology or physiology of other organism"}
{"concept_id": "C3159022", "aliases": [], "types": ["T054"], "canonical_name": "regulation of physiological process of other organism"}
{"concept_id": "C3159023", "aliases": [], "types": ["T045"], "canonical_name": "short tract gene conversion", "definition": "A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor. [GOC:mah, PMID:16954385]"}
{"concept_id": "C3159024", "aliases": [], "types": ["T045"], "canonical_name": "long tract gene conversion", "definition": "A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor. [GOC:mah, PMID:16954385]"}
{"concept_id": "C3159025", "aliases": ["chromosomal crossover"], "types": ["T045"], "canonical_name": "reciprocal DNA recombination"}
{"concept_id": "C3159030", "aliases": ["palmatine metabolism"], "types": ["T044"], "canonical_name": "palmatine metabolic process", "definition": "The chemical reactions and pathways involving palmatine, a berberine alkaloid found in many plants. [GOC:yaf]"}
{"concept_id": "C3159031", "aliases": ["palmatine biosynthesis", "palmatine formation", "palmatine anabolism", "palmatine synthesis"], "types": ["T044"], "canonical_name": "palmatine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of palmatine, a berberine alkaloid found in many plants. [GOC:yaf]"}
{"concept_id": "C3159032", "aliases": ["berbamunine metabolism"], "types": ["T044"], "canonical_name": "berbamunine metabolic process", "definition": "The chemical reactions and pathways involving berbamunine, an isoquinoline alkaloid. [GOC:yaf]"}
{"concept_id": "C3159033", "aliases": ["berbamunine anabolism", "berbamunine biosynthesis", "berbamunine synthesis", "berbamunine formation"], "types": ["T044"], "canonical_name": "berbamunine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid. [GOC:yaf]"}
{"concept_id": "C3159034", "aliases": ["indole alkaloid metabolism"], "types": ["T044"], "canonical_name": "indole alkaloid metabolic process", "definition": "The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton. [GOC:yaf]"}
{"concept_id": "C3159035", "aliases": ["indole alkaloid synthesis", "indole alkaloid biosynthetic process", "indole alkaloid formation", "indole alkaloid biosynthesis"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton. [GOC:yaf]", "canonical_name": "indole alkaloid anabolism"}
{"concept_id": "C3159036", "aliases": ["ergot alkaloid metabolism"], "types": ["T044"], "canonical_name": "ergot alkaloid metabolic process", "definition": "The chemical reactions and pathways involving an ergot alkaloid, an indole alkaloid. [GOC:yaf]"}
{"concept_id": "C3159037", "aliases": ["ergot alkaloid anabolism", "ergot alkaloid biosynthesis", "ergot alkaloid synthesis", "ergot alkaloid formation"], "types": ["T044"], "canonical_name": "ergot alkaloid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an ergot alkaloid. [GOC:yaf]"}
{"concept_id": "C3159038", "aliases": ["growing cell end"], "types": ["T026"], "canonical_name": "growing cell tip", "definition": "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs. [GOC:mah]"}
{"concept_id": "C3159039", "aliases": ["non-growing cell end"], "types": ["T026"], "canonical_name": "non-growing cell tip", "definition": "A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures. [GOC:expert_jd, GOC:mah]"}
{"concept_id": "C3159040", "aliases": [], "types": ["T026"], "canonical_name": "new cell end"}
{"concept_id": "C3159041", "aliases": ["old growing cell end"], "types": ["T026"], "canonical_name": "old growing cell tip", "definition": "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures. [GOC:expert_jd, GOC:mah]"}
{"concept_id": "C3159042", "aliases": ["post-new end take-off new cell tip", "post-NETO new cell tip", "new cell tip after activation of bipolar cell growth", "post-NETO new cell end"], "types": ["T026"], "canonical_name": "new growing cell tip", "definition": "A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth. [GOC:expert_jd, GOC:mah, PMID:19431238]"}
{"concept_id": "C3159043", "aliases": ["post-NETO old cell end", "post-NETO old cell tip", "post-new end take-off old cell tip"], "types": ["T026"], "canonical_name": "old cell tip after activation of bipolar cell growth", "definition": "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures. [GOC:expert_jd, GOC:mah]"}
{"concept_id": "C3159044", "aliases": [], "types": ["T026"], "canonical_name": "endonuclear canal", "definition": "A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope. [GOC:bf, PMID:18359585]"}
{"concept_id": "C3159045", "aliases": ["cloacal development"], "types": ["T042"], "canonical_name": "cloaca development", "definition": "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. [GOC:dgh, ISBN:0582227089]"}
{"concept_id": "C3159046", "aliases": ["photoreceptor outer segment organization", "photoreceptor cell outer segment organisation"], "types": ["T043"], "canonical_name": "photoreceptor cell outer segment organization", "definition": "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials. [ISBN:0824072820, PMID:14507858]"}
{"concept_id": "C3159047", "aliases": [], "types": ["T042"], "canonical_name": "oviduct epithelium development", "definition": "The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct. [GOC:yaf, http://www.thefreedictionary.com/oviduct]"}
{"concept_id": "C3159048", "aliases": [], "types": ["T042"], "canonical_name": "fallopian tube epithelium development"}
{"concept_id": "C3159049", "aliases": ["uterus epithelial development"], "types": ["T042"], "canonical_name": "uterine epithelium development", "definition": "The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:bf, GOC:yaf]"}
{"concept_id": "C3159050", "aliases": [], "types": ["T042"], "canonical_name": "oviduct morphogenesis", "definition": "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. [GOC:yaf, http://www.thefreedictionary.com/oviduct]"}
{"concept_id": "C3159051", "aliases": [], "types": ["T042"], "canonical_name": "fallopian tube morphogenesis"}
{"concept_id": "C3159052", "aliases": [], "types": ["T040"], "canonical_name": "nephric duct elongation", "definition": "The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney. [GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236]"}
{"concept_id": "C3159053", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell differentiation involved in kidney development", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236]"}
{"concept_id": "C3159054", "aliases": ["KRAB domain binding", "Krueppel-associated box binding"], "types": ["T044"], "canonical_name": "Krueppel-associated box domain binding", "definition": "Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors. [InterPro:IPR001909]"}
{"concept_id": "C3159055", "aliases": ["horizontal cell positioning", "laminar positioning of retinal horizontal cell", "retinal horizontal cell positioning", "horizontal cell localisation"], "types": ["T042"], "canonical_name": "horizontal cell localization", "definition": "Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina. [CL:0000745, GOC:bf, GOC:yaf, PMID:18094249]"}
{"concept_id": "C3159056", "aliases": ["CPC localization to spindle midzone", "CPC complex localization to spindle midzone", "chromosomal passenger complex localization to spindle midzone", "chromosome passenger complex localisation to spindle midzone", "chromosome passenger complex localization to spindle equator", "chromosome passenger complex localization to central spindle"], "types": ["T043"], "canonical_name": "chromosome passenger complex localization to spindle midzone", "definition": "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. [GOC:mah, GOC:vw, PMID:15296749]"}
{"concept_id": "C3159057", "aliases": ["eosinophil cell fate commitment"], "types": ["T043"], "canonical_name": "eosinophil fate commitment", "definition": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. [CL:0000771, GOC:BHF, GOC:vk]"}
{"concept_id": "C3159058", "aliases": ["megakaryocyte cell development"], "types": ["T043"], "canonical_name": "megakaryocyte development", "definition": "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. [CL:0000556, GOC:BHF, GOC:vk]"}
{"concept_id": "C3159059", "aliases": ["eosinophil development"], "types": ["T043"], "canonical_name": "eosinophil cell development"}
{"concept_id": "C3159060", "aliases": ["eosinophil cell fate specification"], "types": ["T043"], "canonical_name": "eosinophil fate specification", "definition": "The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. [CL:0000771, GOC:BHF, GOC:vk]"}
{"concept_id": "C3159061", "aliases": ["eosinophil cell fate determination"], "types": ["T043"], "canonical_name": "eosinophil fate determination", "definition": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed. [CL:0000771, GOC:BHF, GOC:vk]"}
{"concept_id": "C3159062", "aliases": ["GATOR complex", "SEA complex", "SEA complex location", "Seh1-associated complex location", "GATOR complex location"], "types": ["T026"], "canonical_name": "Seh1-associated complex", "definition": "A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p. [GOC:jh, PMID:21454883, PMID:23974112]"}
{"concept_id": "C3159063", "aliases": ["glial cell-derived neurotrophic factor receptor signalling pathway", "glial cell line-derived neurotrophic factor receptor signalling pathway", "glial cell derived neurotrophic factor receptor signaling pathway", "GDNF receptor signaling pathway"], "types": ["T044"], "canonical_name": "glial cell-derived neurotrophic factor receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a glial cell-derived neurotrophic factor receptor. [GOC:yaf, PMID:12953054]"}
{"concept_id": "C3159064", "aliases": ["DNA damage foci", "site of DSB", "ionizing radiation-induced foci", "DNA damage focus", "IRIF"], "types": ["T026"], "canonical_name": "site of double-strand break", "definition": "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]"}
{"concept_id": "C3159065", "aliases": ["2'-Deoxyinosine-5'-triphosphate metabolic process", "deoxyinosine 5'-triphosphate metabolic process", "2'-Deoxyinosine 5'-triphosphate metabolic process", "dITP metabolism", "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) metabolic process"], "types": ["T044"], "canonical_name": "dITP metabolic process", "definition": "The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5'-position. [GOC:bf]"}
{"concept_id": "C3159066", "aliases": ["dITP degradation", "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) catabolic process", "dITP breakdown", "2'-Deoxyinosine 5'-triphosphate catabolic process", "dITP catabolism", "2'-Deoxyinosine-5'-triphosphate catabolic process", "deoxyinosine 5'-triphosphate catabolic process"], "types": ["T044"], "canonical_name": "dITP catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position. [GOC:dgf]"}
{"concept_id": "C3159067", "aliases": ["response to potassium", "response to K+ ion"], "types": ["T043"], "canonical_name": "response to potassium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. [GOC:yaf]"}
{"concept_id": "C3159068", "aliases": ["cellular response to K+ ion", "cellular response to potassium"], "types": ["T043"], "canonical_name": "cellular response to potassium ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. [GOC:yaf]"}
{"concept_id": "C3159069", "aliases": ["alphav-beta3 integrin-protein kinase C alpha complex", "alphav-beta3 integrin-PKCa complex", "alphav-beta3 integrin-protein kinase C alpha complex location", "alphav-beta3 integrin-PKCalpha complex location", "alphav-beta3 integrin-PKCa complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-PKCalpha complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha. [GOC:BHF, GOC:ebc, PMID:16014375]"}
{"concept_id": "C3159070", "aliases": ["alphav-beta3 integrin-IGF-1-IGF1R complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-IGF-1-IGF1R complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits. [GOC:BHF, GOC:ebc, PMID:19578119]"}
{"concept_id": "C3159071", "aliases": ["alphav-beta3 integrin-high mobility group box 1 complex", "alphav-beta3 integrin-HMGB1 complex location", "alphav-beta3 integrin-high mobility group box 1 complex location"], "types": ["T026"], "canonical_name": "alphav-beta3 integrin-HMGB1 complex", "definition": "A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein. [GOC:BHF, GOC:ebc, PMID:20826760]"}
{"concept_id": "C3159072", "aliases": ["cilium transition zone", "cilial transition zone"], "types": ["T026"], "canonical_name": "ciliary transition zone", "definition": "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. [GOC:cilia, GOC:kmv, PMID:21422230]"}
{"concept_id": "C3159073", "aliases": ["dITP pyrophosphatase activity", "2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase activity", "deoxyinosine triphosphate pyrophosphatase activity"], "types": ["T044"], "canonical_name": "dITP diphosphatase activity", "definition": "Catalysis of the reaction: dITP + H2O = dIMP + diphosphate. [GOC:dgf, PMID:21548881, RHEA:28342]"}
{"concept_id": "C3159074", "aliases": ["protein K11-linked deubiquitinylation", "protein K11-linked deubiquitylation"], "types": ["T044"], "canonical_name": "protein K11-linked deubiquitination", "definition": "A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein. [GOC:sp, PMID:21596315]"}
{"concept_id": "C3159075", "aliases": ["nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway", "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction", "NLR signaling pathway", "nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway", "nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway"], "types": ["T044"], "canonical_name": "nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. [GOC:sj, PMID:18280719]"}
{"concept_id": "C3159076", "aliases": ["lactate membrane transport"], "types": ["T043"], "canonical_name": "lactate transmembrane transport", "definition": "The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. [GOC:mcc, ISBN:0198506732]"}
{"concept_id": "C3159077", "aliases": ["cellular response to copper starvation"], "types": ["T043"], "canonical_name": "cellular response to copper ion starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions. [GOC:vw, PMID:16467469]"}
{"concept_id": "C3159078", "aliases": ["maintenance of centromeric meiotic sister chromatin cohesion", "maintenance of sister chromatin cohesion at centromere at meiosis I", "maintenance of meiotic sister chromatin cohesion at centromere"], "types": ["T043"], "canonical_name": "maintenance of meiotic sister chromatid cohesion, centromeric", "definition": "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. [GOC:vw, PMID:1708436]"}
{"concept_id": "C3159079", "aliases": ["maintenance of meiotic sister chromatin cohesion along arms", "maintenance of sister chromatin cohesion along arms at meiosis I"], "types": ["T043"], "canonical_name": "maintenance of meiotic sister chromatid cohesion, arms", "definition": "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. [GOC:vw, PMID:1708436]"}
{"concept_id": "C3159080", "aliases": ["DED binding"], "types": ["T044"], "canonical_name": "death effector domain binding", "definition": "Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD). [GOC:ecd, InterPro:IPR001875]"}
{"concept_id": "C3159081", "aliases": [], "types": ["T042"], "canonical_name": "nail development", "definition": "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it. [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)]"}
{"concept_id": "C3159082", "aliases": ["lactate plasma membrane transport"], "types": ["T043"], "canonical_name": "plasma membrane lactate transport", "definition": "The directed movement of lactate across a plasma membrane. [GOC:mcc]"}
{"concept_id": "C3159083", "aliases": [], "types": ["T040"], "canonical_name": "embryonic nail plate morphogenesis", "definition": "The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits. [GOC:BHF, GOC:vk, ISBN:0323025781, PMID:11369996, UBERON:0008198, Wikipedia:Nail_(anatomy)]"}
{"concept_id": "C3159084", "aliases": ["endocrine signalling"], "types": ["T043"], "canonical_name": "endocrine signaling", "definition": "The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other. [GOC:mtg_signaling_feb11, ISBN:0199264678, ISBN:3527303782]"}
{"concept_id": "C3159085", "aliases": ["opioid receptor signaling pathway", "opioid receptor signalling pathway"], "types": ["T044"], "canonical_name": "G protein-coupled opioid receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:bf, PMID:20494127]"}
{"concept_id": "C3159086", "aliases": ["pronephric kidney field specification"], "types": ["T042"], "canonical_name": "pronephric field specification", "definition": "The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159087", "aliases": [], "types": ["T042"], "canonical_name": "specification of pronephric proximal tubule identity", "definition": "The process in which the proximal tubule of the pronephric nephron acquires its identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159088", "aliases": [], "types": ["T042"], "canonical_name": "specification of pronephric tubule identity", "definition": "The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159089", "aliases": ["pronephric tubule formation", "pronephros tubule formation"], "types": ["T042"], "canonical_name": "pronephric nephron tubule formation", "definition": "The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159090", "aliases": [], "types": ["T042"], "canonical_name": "pronephric nephron morphogenesis", "definition": "The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159091", "aliases": [], "types": ["T042"], "canonical_name": "pronephric nephron tubule morphogenesis", "definition": "The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron. [GOC:mtg_kidney_jan10, ZFA:00001558]"}
{"concept_id": "C3159092", "aliases": ["pronephric rectal diverticulum development"], "types": ["T042"], "canonical_name": "rectal diverticulum development", "definition": "The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior. [GOC:mtg_kidney_jan10, PMID:10535314, PMID:18226983, XAO:0001015]"}
{"concept_id": "C3159093", "aliases": [], "types": ["T042"], "canonical_name": "specification of pronephric distal tubule identity", "definition": "The process in which the distal tubule of the pronephric nephron acquires its identity. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159094", "aliases": ["pronephros proximal tubule morphogenesis"], "types": ["T042"], "canonical_name": "pronephric proximal tubule morphogenesis", "definition": "The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159095", "aliases": [], "types": ["T042"], "canonical_name": "pronephric sinus development", "definition": "The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules. [GOC:mtg_kidney_jan10, PMID:10535314, XAO:0000385]"}
{"concept_id": "C3159096", "aliases": [], "types": ["T042"], "canonical_name": "pronephric distal tubule morphogenesis", "definition": "The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159097", "aliases": ["cell differentiation involved in pronephric kidney development"], "types": ["T043"], "canonical_name": "cell differentiation involved in pronephros development", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159098", "aliases": ["cell proliferation involved in pronephric kidney development"], "types": ["T043"], "canonical_name": "cell proliferation involved in pronephros development", "definition": "The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159099", "aliases": ["cell-cell signalling involved in pronephros development", "cell-cell signaling involved in pronephric kidney development"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in pronephros development", "definition": "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159100", "aliases": ["pattern specification involved in pronephric kidney development"], "types": ["T042"], "canonical_name": "pattern specification involved in pronephros development", "definition": "Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3159101", "aliases": [], "types": ["T042"], "canonical_name": "nephrostome development", "definition": "The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity. [GOC:mtg_kidney_jan10, PMID:14686690, PMID:15647339, XAO:0000062]"}
{"concept_id": "C3159102", "aliases": [], "types": ["T042"], "canonical_name": "pronephric nephron development", "definition": "The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros. [GOC:mtg_kidney_jan10, XAO:00002785]"}
{"concept_id": "C3159103", "aliases": [], "types": ["T042"], "canonical_name": "pronephric nephron tubule development", "definition": "The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct. [GOC:mtg_kidney_jan10, PMID:19909807, PMID:9268568]"}
{"concept_id": "C3159104", "aliases": [], "types": ["T042"], "canonical_name": "pronephric glomerulus development", "definition": "The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment. [GOC:dgh, GOC:mtg_kidney_jan10, ZFA:00001557]"}
{"concept_id": "C3159105", "aliases": [], "types": ["T042"], "canonical_name": "pronephric duct development", "definition": "The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney. [GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150]"}
{"concept_id": "C3159106", "aliases": [], "types": ["T042"], "canonical_name": "pronephric duct morphogenesis", "definition": "The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney. [GOC:mtg_kidney_jan10, XAO:0000063, ZFA:0000150]"}
{"concept_id": "C3159107", "aliases": ["suppression by virus of host type I IFN production", "negative regulation by virus of host type I interferon production", "suppression by virus of host interferon type I production"], "types": ["T046"], "canonical_name": "suppression by virus of host type I interferon production", "definition": "Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1113, VZ:875]"}
{"concept_id": "C3159108", "aliases": ["negative regulation by virus of host type I interferon-mediated signaling pathway", "suppression by virus of host type I interferon-mediated signalling pathway", "suppression by virus of host type I IFN-mediated signaling pathway"], "types": ["T040"], "canonical_name": "suppression by virus of host type I interferon-mediated signaling pathway", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1114, VZ:883]"}
{"concept_id": "C3159109", "aliases": ["suppression by virus of host innate immunity", "negative regulation by virus of host innate immune response", "negative regulation by virus of host innate immunity", "inhibition of host innate immune response by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host innate immune response", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense. [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1090]"}
{"concept_id": "C3159110", "aliases": ["negative regulation by virus of host adaptive immunity", "suppression by virus of host acquired immune response", "inhibition of host adaptive immune response by virus", "negative regulation by virus of host adaptive immune response"], "types": ["T043"], "canonical_name": "suppression by virus of host adaptive immune response", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1080]"}
{"concept_id": "C3159111", "aliases": [], "types": ["T046"], "canonical_name": "suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II", "definition": "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex. [GOC:add, GOC:bf, UniProtKB-KW:KW-1116, VZ:820]"}
{"concept_id": "C3159112", "aliases": ["modification by virus of host protein function"], "types": ["T043"], "canonical_name": "modulation by virus of host molecular function", "definition": "The process in which a virus effects a change in the function of a host protein via a direct interaction. [GOC:bf, GOC:sp]"}
{"concept_id": "C3159113", "aliases": ["down regulation by virus of host protein function", "negative regulation by virus of host molecular function", "negative regulation by virus of host protein function", "down-regulation by virus of host protein function"], "types": ["T040"], "canonical_name": "suppression by virus of host molecular function", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein. [GOC:bf, GOC:sp]"}
{"concept_id": "C3159114", "aliases": ["viral inhibition of host receptor", "inhibition by virus of host receptor activity", "suppression by virus of host receptor function", "downregulation by virus of host receptor activity", "down-regulation by virus of host receptor activity", "negative regulation by virus of host receptor activity"], "types": ["T040"], "canonical_name": "suppression by virus of host receptor activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor. [GOC:bf, GOC:sp]"}
{"concept_id": "C3159115", "aliases": ["down regulation by virus of host pattern recognition receptor activity", "viral inhibition of host pattern recognition receptor activity", "down-regulation by virus of host pattern recognition receptor activity", "suppression by virus of host pattern recognition receptor function", "negative regulation by virus of host pattern recognition receptor activity"], "types": ["T040"], "canonical_name": "suppression by virus of host pattern recognition receptor activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. [GOC:bf, GOC:sp]"}
{"concept_id": "C3159116", "aliases": [], "types": ["T042"], "canonical_name": "type 2 immune response", "definition": "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects. [GOC:add, ISBN:0781735149, PMID:18000958, PMID:18007680, PMID:20065995, PMID:20200518]"}
{"concept_id": "C3159117", "aliases": [], "types": ["T043"], "canonical_name": "T-helper cell development"}
{"concept_id": "C3159118", "aliases": [], "types": ["T045"], "canonical_name": "displacement loop biosynthesis"}
{"concept_id": "C3159119", "aliases": [], "types": ["T045"], "canonical_name": "displacement loop formation"}
{"concept_id": "C3159120", "aliases": [], "types": ["T040"], "canonical_name": "cuticle development involved in collagen and cuticulin-based cuticle molting cycle", "definition": "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans. [GOC:mtg_sensu]"}
{"concept_id": "C3159121", "aliases": [], "types": ["T043"], "canonical_name": "gamma-delta T cell development"}
{"concept_id": "C3159122", "aliases": [], "types": ["T044"], "canonical_name": "bacterial triacyl lipoprotein binding"}
{"concept_id": "C3159123", "aliases": [], "types": ["T044"], "canonical_name": "bacterial diacyl lipoprotein binding"}
{"concept_id": "C3159124", "aliases": [], "types": ["T043"], "canonical_name": "cell wall modification during multidimensional cell growth"}
{"concept_id": "C3159125", "aliases": [], "types": ["T044"], "canonical_name": "pterin metabolic process"}
{"concept_id": "C3159126", "aliases": [], "types": ["T044"], "canonical_name": "pterin metabolism"}
{"concept_id": "C3159127", "aliases": [], "types": ["T044"], "canonical_name": "pterin catabolic process"}
{"concept_id": "C3159128", "aliases": [], "types": ["T044"], "canonical_name": "pterin catabolism"}
{"concept_id": "C3159129", "aliases": [], "types": ["T045"], "canonical_name": "dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome", "definition": "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans. [GOC:jl, PMID:11102361, PMID:12672493]"}
{"concept_id": "C3159130", "aliases": ["flavin-containing compound metabolism"], "types": ["T040"], "canonical_name": "flavin-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. [GOC:jl, GOC:mah]"}
{"concept_id": "C3159131", "aliases": ["flavin-containing compound anabolism", "flavin-containing compound formation", "flavin-containing compound biosynthesis", "flavin-containing compound synthesis"], "types": ["T044"], "canonical_name": "flavin-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. [GOC:jl, GOC:mah]"}
{"concept_id": "C3159132", "aliases": ["flavin-containing compound catabolism", "flavin-containing compound catabolic process breakdown", "flavin-containing compound catabolic process degradation"], "types": ["T044"], "canonical_name": "flavin-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. [GOC:jl, GOC:mah]"}
{"concept_id": "C3159135", "aliases": [], "types": ["T045"], "canonical_name": "purine-containing compound salvage", "definition": "Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. [GOC:jl]"}
{"concept_id": "C3159136", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis involved in double-strand break repair via homologous recombination", "definition": "The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination. [GOC:go_curators]"}
{"concept_id": "C3159137", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis involved in double-strand break repair via single-strand annealing", "definition": "The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing. [GOC:go_curators]"}
{"concept_id": "C3159138", "aliases": ["ABC-type efflux permease complex location"], "types": ["T026"], "canonical_name": "ABC-type efflux permease complex"}
{"concept_id": "C3159139", "aliases": [], "types": ["T043"], "canonical_name": "natural killer cell development"}
{"concept_id": "C3159140", "aliases": [], "types": ["T040"], "canonical_name": "interferon production"}
{"concept_id": "C3159141", "aliases": [], "types": ["T040"], "canonical_name": "interleukin production"}
{"concept_id": "C3159142", "aliases": ["ABC-type efflux porter complex location"], "types": ["T026"], "canonical_name": "ABC-type efflux porter complex"}
{"concept_id": "C3159143", "aliases": ["ABC-type uptake permease complex location"], "types": ["T026"], "canonical_name": "ABC-type uptake permease complex"}
{"concept_id": "C3159144", "aliases": [], "types": ["T044"], "canonical_name": "ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance", "definition": "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance. [GOC:jl]"}
{"concept_id": "C3159145", "aliases": [], "types": ["T043"], "canonical_name": "pigment metabolic process involved in developmental pigmentation", "definition": "The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C3159148", "aliases": [], "types": ["T043"], "canonical_name": "CD4-positive, alpha beta T cell development"}
{"concept_id": "C3159149", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CD4-positive, alpha beta T cell development"}
{"concept_id": "C3159150", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CD4-positive, alpha beta T cell development"}
{"concept_id": "C3159151", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CD4-positive, alpha beta T cell development"}
{"concept_id": "C3159152", "aliases": [], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta T cell development"}
{"concept_id": "C3159153", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CD8-positive, alpha-beta T cell development"}
{"concept_id": "C3159154", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CD8-positive, alpha-beta T cell development"}
{"concept_id": "C3159155", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CD8-positive, alpha-beta T cell development"}
{"concept_id": "C3159156", "aliases": [], "types": ["T043"], "canonical_name": "memory T cell development"}
{"concept_id": "C3159157", "aliases": [], "types": ["T043"], "canonical_name": "regulation of memory T cell development"}
{"concept_id": "C3159158", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of memory T cell development"}
{"concept_id": "C3159159", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of memory T cell development"}
{"concept_id": "C3159160", "aliases": [], "types": ["T040"], "canonical_name": "ethanol biosynthetic process involved in glucose fermentation to ethanol", "definition": "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C3159161", "aliases": [], "types": ["T043"], "canonical_name": "pigment metabolic process involved in pigmentation", "definition": "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C3159162", "aliases": [], "types": ["T043"], "canonical_name": "pigment metabolic process involved in pigment accumulation", "definition": "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, as part of the accumulation of pigment. [GOC:jl]"}
{"concept_id": "C3159163", "aliases": [], "types": ["T044"], "canonical_name": "pigment biosynthetic process involved in pigment accumulation", "definition": "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, resulting in pigment accumulation. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C3159164", "aliases": [], "types": ["T044"], "canonical_name": "anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light", "definition": "The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C3159165", "aliases": ["regulation of myosin II filament organisation"], "types": ["T043"], "canonical_name": "regulation of myosin II filament organization", "definition": "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules. [GOC:jl]"}
{"concept_id": "C3159166", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylinositol 3-kinase activity"}
{"concept_id": "C3159167", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of phosphatidylinositol 3-kinase activity"}
{"concept_id": "C3159168", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylinositol 3-kinase activity"}
{"concept_id": "C3159169", "aliases": [], "types": ["T044"], "canonical_name": "ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process", "definition": "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C3159170", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial fragmentation involved in apoptosis"}
{"concept_id": "C3159171", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in single-species biofilm formation in or on host organism", "definition": "The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a host species. [GOC:jl]"}
{"concept_id": "C3159172", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in biofilm formation", "definition": "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C3159173", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in single-species biofilm formation", "definition": "The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C3159174", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in multi-species biofilm formation", "definition": "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C3159175", "aliases": [], "types": ["T042"], "canonical_name": "primary ovarian follicle growth involved in double layer follicle stage", "definition": "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), as part of the double layer follicle stage of oogenesis. [GOC:mtg_mpo]"}
{"concept_id": "C3159176", "aliases": [], "types": ["T042"], "canonical_name": "primary ovarian follicle growth involved in primary follicle stage", "definition": "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) as part of the primary follicle stage of oogenesis. [GOC:mtg_mpo]"}
{"concept_id": "C3159178", "aliases": [], "types": ["T042"], "canonical_name": "development involved in symbiotic interaction"}
{"concept_id": "C3159186", "aliases": [], "types": ["T038"], "canonical_name": "modulation of development of symbiont involved in interaction with host"}
{"concept_id": "C3159188", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of development of symbiont involved in interaction with host"}
{"concept_id": "C3159190", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of development of symbiont involved in interaction with host"}
{"concept_id": "C3159191", "aliases": ["development on or near surface of other organism involved in symbiotic interaction"], "types": ["T040"], "canonical_name": "development on or near surface of other organism during symbiotic interaction"}
{"concept_id": "C3159193", "aliases": ["nitrogen compound breakdown", "nitrogen compound degradation"], "types": ["T044"], "canonical_name": "nitrogen compound catabolism"}
{"concept_id": "C3159194", "aliases": ["nitrogen compound synthesis", "nitrogen compound formation", "nitrogen compound anabolism"], "types": ["T044"], "canonical_name": "nitrogen compound biosynthesis"}
{"concept_id": "C3159195", "aliases": [], "types": ["T044"], "canonical_name": "protein K6-linked deubiquitination", "definition": "A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein. [GOC:sp]"}
{"concept_id": "C3159196", "aliases": ["protein K27-linked polyubiquitination"], "types": ["T044"], "canonical_name": "protein K27-linked ubiquitination", "definition": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein. [PMID:19345326]"}
{"concept_id": "C3159197", "aliases": [], "types": ["T043"], "canonical_name": "protein secretion by the type VII secretion system", "definition": "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system. [PMID:17922044, PMID:19876390]"}
{"concept_id": "C3159198", "aliases": [], "types": ["T044"], "canonical_name": "L-aspartate:fumarate oxidoreductase activity", "definition": "Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate. [PMID:20149100]"}
{"concept_id": "C3159199", "aliases": ["cell migration involved in wound healing epiboly"], "types": ["T043"], "canonical_name": "wound healing, spreading of cells", "definition": "The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface. [GOC:jl]"}
{"concept_id": "C3159200", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to leptin stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. [GOC:yaf]"}
{"concept_id": "C3159201", "aliases": ["response to leptin stimulus"], "types": ["T043"], "canonical_name": "response to leptin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. [GOC:yaf]"}
{"concept_id": "C3159202", "aliases": ["ER quality control compartment", "ER-derived quality control compartment", "ERQC"], "types": ["T026"], "canonical_name": "endoplasmic reticulum quality control compartment", "definition": "A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. [PMID:11408579]"}
{"concept_id": "C3159203", "aliases": ["RARE binding"], "types": ["T045"], "canonical_name": "retinoic acid-responsive element binding", "definition": "Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671]"}
{"concept_id": "C3159205", "aliases": [], "types": ["T044"], "canonical_name": "ion channel binding"}
{"concept_id": "C3159206", "aliases": ["dendritic spine neck", "spine neck", "neck"], "types": ["T026"], "definition": "Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine. [GOC:nln]", "canonical_name": "pedicle"}
{"concept_id": "C3159207", "aliases": [], "types": ["T026"], "canonical_name": "dendritic spine head", "definition": "Distal part of the dendritic spine, that carries the post-synaptic density. [GOC:BHF, GOC:nln, GOC:rl]"}
{"concept_id": "C3159208", "aliases": ["canonical Wnt receptor signalling pathway involved in positive regulation of endothelial cell migration", "canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159209", "aliases": ["canonical Wnt-activated signaling pathway involved in positive regulation of cell-cell adhesion", "canonical Wnt receptor signalling pathway involved in positive regulation of cell-cell adhesion", "canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159210", "aliases": ["canonical Wnt receptor signaling pathway involved in positive regulation of wound healing", "canonical Wnt receptor signalling pathway involved in positive regulation of wound healing", "canonical Wnt-activated signaling pathway involved in positive regulation of wound healing"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in positive regulation of wound healing", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159211", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion mediated by cadherin", "definition": "The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains. [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970]"}
{"concept_id": "C3159212", "aliases": ["Wnt receptor signalling pathway involved in dorsal/ventral axis specification", "Wnt receptor signaling pathway involved in dorsal/ventral axis specification", "Wnt-activated signaling pathway involved in dorsal/ventral axis specification"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in dorsal/ventral axis specification", "definition": "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis. [GOC:jl, GOC:yaf]"}
{"concept_id": "C3159213", "aliases": ["Wnt receptor signaling pathway involved in digestive tract morphogenesis", "Wnt receptor signalling pathway involved in digestive tract morphogenesis"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in digestive tract morphogenesis", "definition": "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159214", "aliases": ["canonical Wnt receptor signalling pathway involved in positive regulation of epithelial to mesenchymal transition", "canonical Wnt-activated signaling pathway involved in positive regulation of epithelial to mesenchymal transition", "canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159215", "aliases": ["canonical Wnt receptor signaling pathway involved in neural crest cell differentiation", "canonical Wnt receptor signalling pathway involved in neural crest cell differentiation", "canonical Wnt-activated signaling pathway involved in neural crest cell differentiation"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in neural crest cell differentiation", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159216", "aliases": ["canonical Wnt receptor signalling pathway involved in negative regulation of apoptosis", "canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis", "canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in negative regulation of apoptotic process", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process. [GOC:BHF, GOC:jl, GOC:mtg_apoptosis]"}
{"concept_id": "C3159217", "aliases": ["canonical Wnt receptor signaling pathway involved in positive regulation of apoptosis", "canonical Wnt receptor signalling pathway involved in positive regulation of apoptosis", "canonical Wnt-activated signaling pathway involved in positive regulation of apoptotic process", "canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in positive regulation of apoptotic process", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process. [GOC:BHF, GOC:jl, GOC:mtg_apoptosis]"}
{"concept_id": "C3159218", "aliases": ["canonical Wnt-activated signaling pathway involved in mesenchymal stem cell differentiation", "canonical Wnt receptor signalling pathway involved in mesenchymal stem cell differentiation", "canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159219", "aliases": ["canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "canonical Wnt receptor signalling pathway involved in osteoblast differentiation", "canonical Wnt-activated signaling pathway involved in osteoblast differentiation"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in osteoblast differentiation", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159220", "aliases": ["canonical Wnt receptor signalling pathway involved in regulation of cell proliferation", "canonical Wnt receptor signaling pathway involved in regulation of cell proliferation", "canonical Wnt-activated signaling pathway involved in regulation of cell proliferation"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in regulation of cell proliferation", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159221", "aliases": [], "types": ["T043"], "canonical_name": "sodium-dependent phosphate transport", "definition": "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions. [GOC:BHF, GOC:jl]"}
{"concept_id": "C3159222", "aliases": ["pancreatic beta cell proliferation", "pancreatic B cell proliferation"], "types": ["T043"], "canonical_name": "type B pancreatic cell proliferation", "definition": "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. [GOC:jl, GOC:yaf]"}
{"concept_id": "C3159223", "aliases": ["canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation", "canonical Wnt receptor signalling pathway involved in regulation of type B pancreatic cell proliferation", "canonical Wnt receptor signaling pathway involved in regulation of pancreatic B cell proliferation", "canonical Wnt-activated signaling pathway involved in regulation of type B pancreatic cell proliferation", "canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation", "canonical Wnt receptor signalling pathway involved in regulation of pancreatic B cell proliferation"], "types": ["T043"], "canonical_name": "canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin. [GOC:jl, GOC:yaf]"}
{"concept_id": "C3159224", "aliases": ["cellular response to FGF stimulus"], "types": ["T043"], "canonical_name": "cellular response to fibroblast growth factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus. [GOC:jl, GOC:yaf]"}
{"concept_id": "C3159225", "aliases": ["stromal-epithelial cell signalling involved in prostate gland development"], "types": ["T043"], "canonical_name": "stromal-epithelial cell signaling involved in prostate gland development", "definition": "The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development. [GOC:jl, GOC:yaf]"}
{"concept_id": "C3159226", "aliases": ["fibroblast apoptosis"], "types": ["T043"], "canonical_name": "fibroblast apoptotic process", "definition": "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]"}
{"concept_id": "C3159227", "aliases": ["DNA-dependent DNA replication maintenance of fidelity", "maintenance of fidelity involved in DNA-dependent DNA replication"], "types": ["T045"], "canonical_name": "DNA-templated DNA replication maintenance of fidelity", "definition": "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. [GOC:mah, GOC:vw]"}
{"concept_id": "C3159228", "aliases": [], "types": ["T043"], "canonical_name": "cytotoxic T cell development"}
{"concept_id": "C3159229", "aliases": [], "types": ["T043"], "canonical_name": "regulatory T cell development"}
{"concept_id": "C3159230", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell signalling involved in cell fate specification"}
{"concept_id": "C3159231", "aliases": [], "types": ["T042"], "canonical_name": "neural groove formation"}
{"concept_id": "C3159232", "aliases": ["insertion of proteins into mitochondrial membranes during the induction of apoptosis", "protein insertion into mitochondrion membrane during induction of apoptosis", "protein insertion into mitochondrial membrane involved in induction of apoptosis"], "types": ["T043"], "canonical_name": "protein insertion into mitochondrial membrane during induction of apoptosis"}
{"concept_id": "C3159233", "aliases": [], "types": ["T043"], "canonical_name": "NK T cell development"}
{"concept_id": "C3159238", "aliases": ["1,3-beta-D-glucan binding"], "types": ["T044"], "canonical_name": "(1->3)-beta-D-glucan binding", "definition": "Binding to a (1->3)-beta-D-glucan. [PMID:14707091]"}
{"concept_id": "C3159239", "aliases": ["beta-1,3-D-glucan receptor activity", "(1->3)-beta-D-glucan receptor activity", "(1,3)-beta-D-glucan receptor activity", "1,3-beta-D-glucan receptor activity"], "types": ["T044"], "canonical_name": "(1->3)-beta-D-glucan immune receptor activity", "definition": "Combining with (1->3)-beta-D-glucans to initiate an innate immune response. [PMID:14707091]"}
{"concept_id": "C3159240", "aliases": [], "types": ["T043"], "canonical_name": "B-1 B cell development"}
{"concept_id": "C3159241", "aliases": [], "types": ["T043"], "canonical_name": "regulation of B-1 B cell development"}
{"concept_id": "C3159242", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of B-1 B cell development"}
{"concept_id": "C3159243", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of B-1 B cell development"}
{"concept_id": "C3159247", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure", "definition": "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure. [ISBN:0721643949]"}
{"concept_id": "C3159248", "aliases": [], "types": ["T043"], "canonical_name": "secretion of vasopressin involved in fast regulation of systemic arterial blood pressure", "definition": "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure. [ISBN:0721643949]"}
{"concept_id": "C3159249", "aliases": [], "types": ["T043"], "canonical_name": "regulation of B cell development"}
{"concept_id": "C3159250", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of B cell development"}
{"concept_id": "C3159251", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of B cell development"}
{"concept_id": "C3159252", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of T cell development"}
{"concept_id": "C3159253", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of T cell development"}
{"concept_id": "C3159254", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytotoxic T cell development"}
{"concept_id": "C3159255", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cytotoxic T cell development"}
{"concept_id": "C3159256", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cytotoxic T cell development"}
{"concept_id": "C3159257", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gamma-delta T cell development"}
{"concept_id": "C3159258", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of gamma-delta T cell development"}
{"concept_id": "C3159259", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of gamma-delta T cell development"}
{"concept_id": "C3159260", "aliases": [], "types": ["T043"], "canonical_name": "regulation of regulatory T cell development"}
{"concept_id": "C3159261", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of regulatory T cell development"}
{"concept_id": "C3159262", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of regulatory T cell development"}
{"concept_id": "C3159263", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lymphocyte development"}
{"concept_id": "C3159264", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of lymphocyte development"}
{"concept_id": "C3159265", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of lymphocyte development"}
{"concept_id": "C3159266", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T-helper cell development"}
{"concept_id": "C3159267", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of T-helper cell development"}
{"concept_id": "C3159268", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of T-helper cell development"}
{"concept_id": "C3159269", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T-helper 1 cell development"}
{"concept_id": "C3159270", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of T-helper 1 cell development"}
{"concept_id": "C3159271", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of T-helper 1 cell development"}
{"concept_id": "C3159272", "aliases": [], "types": ["T043"], "canonical_name": "regulation of T-helper 2 cell development"}
{"concept_id": "C3159273", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of T-helper 2 cell development"}
{"concept_id": "C3159274", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of T-helper 2 cell development"}
{"concept_id": "C3159301", "aliases": ["phenol-containing compound anabolism", "phenol-containing compound synthesis", "phenol-containing compound biosynthesis", "phenol-containing compound formation"], "types": ["T044"], "canonical_name": "phenol-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. [GOC:ai]"}
{"concept_id": "C3159308", "aliases": [], "types": ["T044"], "canonical_name": "purinergic receptor activity"}
{"concept_id": "C3159310", "aliases": ["OIS"], "types": ["T046"], "definition": "A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family. [GOC:BHF]", "canonical_name": "oncogene-induced cell senescence"}
{"concept_id": "C3160734", "aliases": [], "types": ["T044"], "definition": "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732]", "canonical_name": "dephosphorylation"}
{"concept_id": "C3160986", "aliases": ["down regulation of cytokine production during immune response", "down-regulation of cytokine production during immune response", "downregulation of cytokine production during immune response"], "types": ["T040"], "canonical_name": "negative regulation of cytokine production involved in immune response", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. [GOC:add]"}
{"concept_id": "C3160987", "aliases": ["down-regulation of superoxide release", "negative regulation of superoxide release", "downregulation of superoxide release", "down regulation of superoxide release"], "types": ["T043"], "canonical_name": "negative regulation of superoxide anion generation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell. [GOC:mah]"}
{"concept_id": "C3160988", "aliases": ["positive regulation of superoxide release", "up regulation of superoxide release", "upregulation of superoxide release", "up-regulation of superoxide release"], "types": ["T043"], "canonical_name": "positive regulation of superoxide anion generation", "definition": "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell. [GOC:mah]"}
{"concept_id": "C3160991", "aliases": ["nickel homeostasis"], "types": ["T043"], "canonical_name": "nickel cation homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell. [GOC:kmv]"}
{"concept_id": "C3160996", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by virus of host protein function"}
{"concept_id": "C3161000", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by virus of host pattern recognition receptor activity"}
{"concept_id": "C3161009", "aliases": [], "types": ["T040"], "canonical_name": "passive immune evasion"}
{"concept_id": "C3161010", "aliases": [], "types": ["T040"], "canonical_name": "active immune evasion"}
{"concept_id": "C3161018", "aliases": ["isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway involved in terpenoid biosynthetic process"], "types": ["T044"], "canonical_name": "isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. [GOC:ai]"}
{"concept_id": "C3161019", "aliases": [], "types": ["T044"], "canonical_name": "isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway that contributes to terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates. [GOC:ai]"}
{"concept_id": "C3161028", "aliases": ["down-regulation of apoptosis in bone marrow", "negative regulation of bone marrow cell programmed cell death by apoptosis", "negative regulation of programmed cell death, bone marrow cells", "negative regulation of apoptotic process in bone marrow", "negative regulation of programmed cell death of bone marrow cells by apoptosis", "negative regulation of killing of bone marrow cells", "negative regulation of bone marrow cell apoptosis", "negative regulation of apoptosis in bone marrow", "downregulation of apoptosis in bone marrow", "down regulation of apoptosis in bone marrow"], "types": ["T043"], "canonical_name": "negative regulation of apoptotic process in bone marrow cell", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow. [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141]"}
{"concept_id": "C3161032", "aliases": [], "types": ["T044"], "canonical_name": "efflux-type borate transporter"}
{"concept_id": "C3178863", "aliases": [], "types": ["T043"], "definition": "Cell regulatory signaling system that controls progression through S PHASE and stabilizes the replication forks during conditions that could affect the fidelity of DNA REPLICATION, such as DNA DAMAGE or depletion of nucleotide pools.", "canonical_name": "S-phase checkpoint"}
{"concept_id": "C3178900", "aliases": [], "types": ["T043"], "definition": "Type of cell division of stem cells resulting in one daughter cell identical to the original stem cell and another non-stem daughter cell. This type of cell differentiation is achieved by asymmetrical segregation of cell fate determinants (see CELL POLARITY) and orientation of the MITOTIC SPINDLE in the context of intrinsic and extrinsic cues (STEM CELL NICHE).", "canonical_name": "asymmetric stem cell division"}
{"concept_id": "C3178997", "aliases": ["endoplasmic reticulum-associated degradation", "protein degradation by ERAD"], "types": ["T044"], "definition": "A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.", "canonical_name": "ERAD pathway"}
{"concept_id": "C3266886", "aliases": [], "types": ["T042"], "canonical_name": "anterior/posterior pattern specification, imaginal disc", "definition": "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form. [GOC:bf, ISBN:0879694238]"}
{"concept_id": "C3266896", "aliases": ["commitment to apoptosis", "activation of apoptosis"], "types": ["T043"], "canonical_name": "activation of apoptosis", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C3266931", "aliases": ["up regulation of myeloid cell apoptosis", "up-regulation of myeloid cell apoptosis", "positive regulation of myeloid cell apoptosis", "upregulation of myeloid cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of myeloid cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C3266932", "aliases": ["ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 4-phosphotransferase activity", "phosphatidylinositol 3-phosphate 4-kinase activity"], "types": ["T044"], "canonical_name": "1-phosphatidylinositol-3-phosphate 4-kinase activity", "definition": "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). [PMID:9211928, PMID:9367159, PMID:9660759, RHEA:63688]"}
{"concept_id": "C3266933", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptotic process involved in mammary gland involution", "definition": "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution. [GOC:dph, GOC:mtg_apoptosis, PMID:15282149]"}
{"concept_id": "C3268324", "aliases": [], "types": ["T044"], "canonical_name": "alpha-dystroglycan binding"}
{"concept_id": "C3268325", "aliases": [], "types": ["T044"], "canonical_name": "beta-dystroglycan binding"}
{"concept_id": "C3268326", "aliases": ["5-lipoxygenase complex location"], "types": ["T026"], "canonical_name": "5-lipoxygenase complex", "definition": "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity. [PMID:19075240]"}
{"concept_id": "C3268327", "aliases": [], "types": ["T044"], "canonical_name": "cytoplasmic translation", "definition": "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd]"}
{"concept_id": "C3268328", "aliases": [], "types": ["T045"], "canonical_name": "cytoplasmic translational elongation", "definition": "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm. [GOC:hjd]"}
{"concept_id": "C3268329", "aliases": [], "types": ["T045"], "canonical_name": "cytoplasmic translational initiation", "definition": "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [GOC:hjd]"}
{"concept_id": "C3268330", "aliases": [], "types": ["T045"], "canonical_name": "cytoplasmic translational termination", "definition": "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon. [GOC:hjd]"}
{"concept_id": "C3268331", "aliases": ["creatine kinase complex location"], "types": ["T026"], "canonical_name": "creatine kinase complex", "definition": "A protein complex having creatine kinase activity. [GOC:hjd]"}
{"concept_id": "C3268332", "aliases": ["cytosolic creatine kinase complex location"], "types": ["T026"], "canonical_name": "cytosolic creatine kinase complex", "definition": "A dimeric protein complex having creatine kinase activity. [PMID:173175]"}
{"concept_id": "C3268333", "aliases": ["mitochondrial creatine kinase complex location"], "types": ["T026"], "canonical_name": "mitochondrial creatine kinase complex", "definition": "An octomeric protein complex having creatine kinase activity. [PMID:16236486]"}
{"concept_id": "C3268334", "aliases": [], "types": ["T045"], "canonical_name": "translation reinitiation", "definition": "A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon. [PMID:18056426, PMID:18765792]"}
{"concept_id": "C3268335", "aliases": ["PRPP synthetase complex location", "ribose phosphate diphosphokinase complex location", "phosphoribosylpyrophosphate synthetase complex", "phosphoribosylpyrophosphate synthetase complex location", "PRPP synthetase complex"], "types": ["T026"], "canonical_name": "ribose phosphate diphosphokinase complex", "definition": "A protein complex having ribose phosphate diphosphokinase activity. [GO:hjd, PMID:9348095]"}
{"concept_id": "C3268336", "aliases": [], "types": ["T045"], "canonical_name": "cap-independent translational initiation", "definition": "The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation. [PMID:17284590]"}
{"concept_id": "C3268337", "aliases": [], "types": ["T045"], "canonical_name": "cap-dependent translational initiation", "definition": "The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation. [PMID:17284590, PMID:19604130]"}
{"concept_id": "C3268338", "aliases": [], "types": ["T045"], "canonical_name": "IRES-dependent translational initiation of linear mRNA", "definition": "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation. [PMID:17284590]"}
{"concept_id": "C3268339", "aliases": ["MAML1-RBP-Jkappa-Notch1 complex location", "MAML1-CSL-ICN1", "MAML1-CSL-Notch1 complex location", "MAML1-RBP-Jkappa- ICN1 complex location", "MAML1-CSL-Notch1 complex", "MAML1-RBP-Jkappa-Notch1 complex"], "types": ["T026"], "canonical_name": "MAML1-RBP-Jkappa- ICN1 complex", "definition": "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling. [CORUM:2949, PMID:16510869]"}
{"concept_id": "C3268340", "aliases": [], "types": ["T043"], "canonical_name": "hepatocyte cell migration", "definition": "The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes. [CL:0000182, PMID:9794819]"}
{"concept_id": "C3268341", "aliases": [], "types": ["T045"], "canonical_name": "2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis", "definition": "The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs. [UniPathway:UPA00729]"}
{"concept_id": "C3268342", "aliases": [], "types": ["T044"], "canonical_name": "Ser-tRNA(Ala) hydrolase activity", "definition": "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala). [GOC:hjd, PMID:21285375]"}
{"concept_id": "C3268343", "aliases": ["xanthine dehydrogenase complex location"], "types": ["T026"], "canonical_name": "xanthine dehydrogenase complex", "definition": "A homodimeric protein complex having xanthine dehydrogenase activity. [GOC:hjd, PMID:8224915]"}
{"concept_id": "C3268347", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity", "definition": "Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate. [RHEA:13933]"}
{"concept_id": "C3268348", "aliases": [], "types": ["T044"], "canonical_name": "ADP-dependent propionyl coenzyme A hydrolase activity"}
{"concept_id": "C3268349", "aliases": [], "types": ["T044"], "canonical_name": "ADP-dependent propionyl-CoA hydrolase activity"}
{"concept_id": "C3268354", "aliases": [], "types": ["T042"], "canonical_name": "cibarial fish-trap bristle morphogenesis", "definition": "The process in which the anatomical structures of a cibarial fish-trap bristle are generated and organized. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium. [FBbt:00004136, GOC:rc]"}
{"concept_id": "C3268355", "aliases": ["fish-trap bristle development"], "types": ["T042"], "canonical_name": "cibarial fish-trap bristle development", "definition": "The process whose specific outcome is the progression of the cibarial fish-trap bristle over time, from its formation to the mature structure. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium. [FBbt:00004136, GOC:rc]"}
{"concept_id": "C3268357", "aliases": ["p38 MAPK signalling"], "types": ["T044"], "canonical_name": "p38 MAPK signaling"}
{"concept_id": "C3268358", "aliases": [], "types": ["T043"], "canonical_name": "cell growth mode switching, bipolar to monopolar", "definition": "The process in which a cell switches from bipolar cell growth to monopolar cell growth. [GOC:ai]"}
{"concept_id": "C3268359", "aliases": [], "types": ["T044"], "canonical_name": "brain nitric-oxide synthase biosynthetic process"}
{"concept_id": "C3268360", "aliases": [], "types": ["T044"], "canonical_name": "endothelial nitric-oxide synthase biosynthetic process"}
{"concept_id": "C3268361", "aliases": [], "types": ["T044"], "canonical_name": "inducible nitric-oxide synthase biosynthetic process"}
{"concept_id": "C3268362", "aliases": ["nitric-oxide synthase-1 biosynthetic process"], "types": ["T044"], "canonical_name": "NOS1 biosynthesis"}
{"concept_id": "C3268363", "aliases": [], "types": ["T044"], "canonical_name": "nitric-oxide synthase-3 biosynthetic process"}
{"concept_id": "C3268364", "aliases": [], "types": ["T044"], "canonical_name": "NOS2 biosynthesis"}
{"concept_id": "C3268365", "aliases": [], "types": ["T044"], "canonical_name": "NOS3 biosynthesis"}
{"concept_id": "C3268366", "aliases": ["up regulation of arginine biosynthesis", "upregulation of arginine anabolism", "upregulation of arginine biosynthesis", "up-regulation of arginine biosynthetic process", "up regulation of arginine biosynthetic process", "upregulation of arginine biosynthetic process", "positive regulation of arginine anabolism", "up regulation of arginine synthesis", "up regulation of arginine formation", "upregulation of arginine synthesis", "up-regulation of arginine formation", "upregulation of arginine formation", "up regulation of arginine anabolism", "up-regulation of arginine synthesis", "up-regulation of arginine anabolism", "up-regulation of arginine biosynthesis", "positive regulation of arginine formation", "positive regulation of arginine biosynthesis", "positive regulation of arginine synthesis"], "types": ["T044"], "canonical_name": "positive regulation of arginine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process. [GOC:dgf, GOC:TermGenie]"}
{"concept_id": "C3268367", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of programmed cell death in other organism during symbiotic interaction"}
{"concept_id": "C3268368", "aliases": [], "types": ["T040"], "canonical_name": "modulation by symbiont of host apoptosis"}
{"concept_id": "C3268369", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host apoptosis"}
{"concept_id": "C3268370", "aliases": ["immune response-regulating cell surface receptor signalling pathway involved in phagocytosis", "phagocytosis triggered by activation of immune response cell surface activating receptor"], "types": ["T044"], "canonical_name": "immune response-regulating cell surface receptor signaling pathway involved in phagocytosis", "definition": "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. [GO_REF:0000022, GOC:add, GOC:bf, ISBN:0781735149]"}
{"concept_id": "C3268371", "aliases": [], "types": ["T043"], "canonical_name": "serotonin release involved in inflammatory response"}
{"concept_id": "C3268372", "aliases": [], "types": ["T043"], "canonical_name": "serotonin release by mast cell"}
{"concept_id": "C3268373", "aliases": [], "types": ["T043"], "canonical_name": "serotonin release by platelet"}
{"concept_id": "C3268374", "aliases": [], "types": ["T043"], "canonical_name": "serotonin release by basophil"}
{"concept_id": "C3268375", "aliases": ["mcm5 modification", "mcm5s2U34 biosynthesis", "tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis"], "types": ["T045"], "canonical_name": "tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "definition": "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine. [GOC:hjd, UniPathway:UPA00988]"}
{"concept_id": "C3268376", "aliases": [], "types": ["T045"], "canonical_name": "archaeosine-tRNA biosynthetic process", "definition": "The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs. [GOC:hjd, UniPathway:UPA00393]"}
{"concept_id": "C3268377", "aliases": ["meta-coactivator complex location", "meta-coactivator complex", "MECO complex location"], "types": ["T026"], "canonical_name": "MECO complex", "definition": "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II. [GOC:hjd, PMID:20508642]"}
{"concept_id": "C3268378", "aliases": ["heart valve remodelling"], "types": ["T040"], "canonical_name": "heart valve remodeling"}
{"concept_id": "C3268379", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic process involved in outflow tract morphogenesis", "definition": "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries. [GOC:mtg_apoptosis, GOC:mtg_heart]"}
{"concept_id": "C3268380", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic process involved in heart morphogenesis", "definition": "Any apoptotic process that contributes to the shaping of the heart. [GOC:mtg_apoptosis, GOC:mtg_heart]"}
{"concept_id": "C3268381", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in atrial ventricular junction remodeling"}
{"concept_id": "C3268384", "aliases": ["transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding", "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity"], "types": ["T044"], "canonical_name": "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity"}
{"concept_id": "C3268385", "aliases": [], "types": ["T044"], "canonical_name": "3-oxoacyl-thioester reductase activity"}
{"concept_id": "C3268390", "aliases": [], "types": ["T044"], "canonical_name": "jasmonoyl-isoleucine-12-hydroxylase activity", "definition": "Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O. [MetaCyc:RXN-12421, PMID:21576464]"}
{"concept_id": "C3268391", "aliases": ["cellular glucuronide biosynthetic process", "cellular glucuronoside biosynthesis", "cellular glucuronide biosynthesis", "cellular glucuronoside biosynthetic process"], "types": ["T044"], "canonical_name": "cellular glucuronidation", "definition": "The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. [GOC:BHF]"}
{"concept_id": "C3268392", "aliases": ["flavonoid glucuronoside biosynthetic process", "flavonoid glucuronoside biosynthesis", "flavonoid glucuronide biosynthetic process", "flavonoid glucuronide biosynthesis"], "types": ["T044"], "canonical_name": "flavonoid glucuronidation", "definition": "The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor. [GOC:BHF, PMID:20056724]"}
{"concept_id": "C3268393", "aliases": [], "types": ["T044"], "canonical_name": "xenobiotic glucuronidation", "definition": "The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion. [GOC:BHF, PMID:20056724]"}
{"concept_id": "C3268394", "aliases": ["(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate metabolic process", "2-mercaptoergothioneine trimethylbetaine metabolic process", "ergothioneine metabolism", "2-mercaptoergothioneine trimethylbetaine metabolism"], "types": ["T044"], "canonical_name": "ergothioneine metabolic process", "definition": "The chemical reactions and pathways involving ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties. [Wikipedia:Ergothioneine]"}
{"concept_id": "C3268395", "aliases": ["ergothioneine synthesis", "2-mercaptoergothioneine trimethylbetaine synthesis", "2-mercaptoergothioneine trimethylbetaine biosynthetic process", "ergothioneine biosynthesis", "2-mercaptoergothioneine trimethylbetaine biosynthesis", "2-mercaptoergothioneine trimethylbetaine anabolism", "2-mercaptoergothioneine trimethylbetaine formation", "ergothioneine formation", "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate biosynthetic process", "ergothioneine anabolism"], "types": ["T044"], "canonical_name": "ergothioneine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties. [Wikipedia:Ergothioneine]"}
{"concept_id": "C3268396", "aliases": ["ergothioneine breakdown", "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate catabolic process", "2-mercaptoergothioneine trimethylbetaine breakdown", "2-mercaptoergothioneine trimethylbetaine catabolism", "ergothioneine degradation", "2-mercaptoergothioneine trimethylbetaine catabolic process", "2-mercaptoergothioneine trimethylbetaine degradation", "ergothioneine catabolism"], "types": ["T044"], "canonical_name": "ergothioneine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties. [Wikipedia:Ergothioneine]"}
{"concept_id": "C3268397", "aliases": ["cellular histidine derivative metabolism", "cellular modified histidine metabolism", "modified histidine metabolism", "modified histidine metabolic process", "histidine derivative metabolic process", "cellular histidine derivative metabolic process"], "types": ["T044"], "canonical_name": "cellular modified histidine metabolic process", "definition": "The chemical reactions and pathways involving compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:ai]"}
{"concept_id": "C3268398", "aliases": ["cellular histidine derivative degradation", "cellular histidine derivative catabolism", "modified histidine catabolic process", "cellular modified histidine breakdown", "histidine derivative catabolic process", "cellular histidine derivative catabolic process", "modified histidine catabolism", "cellular modified histidine degradation", "cellular modified histidine catabolism", "cellular histidine derivative breakdown"], "types": ["T044"], "canonical_name": "cellular modified histidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:ai]"}
{"concept_id": "C3268399", "aliases": ["cellular histidine derivative anabolism", "cellular modified histidine anabolism", "cellular modified histidine formation", "cellular histidine derivative synthesis", "histidine derivative biosynthetic process", "cellular histidine derivative biosynthesis", "cellular histidine derivative formation", "cellular histidine derivative biosynthetic process", "cellular modified histidine synthesis", "cellular modified histidine biosynthesis"], "types": ["T044"], "canonical_name": "cellular modified histidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:ai]"}
{"concept_id": "C3268400", "aliases": [], "types": ["T044"], "canonical_name": "ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine"}
{"concept_id": "C3268401", "aliases": ["S-adenosyl-L-methionine:N-alpha-dimethyl-L-histidine N-alpha-methyltransferase activity", "S-adenosyl-L-methionine:alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity", "methylhistidine methyltransferase activity"], "types": ["T044"], "canonical_name": "methylhistidine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine. [EC:2.1.1.44]"}
{"concept_id": "C3268402", "aliases": ["S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity", "histidine methyltransferase activity", "S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity"], "types": ["T044"], "canonical_name": "histidine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine. [EC:2.1.1.44]"}
{"concept_id": "C3268403", "aliases": ["histidine catabolism to hercynine", "histidine betaine biosynthesis from histidine", "histidine catabolic process to hercynine", "histidine catabolism to N-alpha,N-alpha,N-alpha-trimethyl-L-histidine", "hercynine biosynthesis from histidine"], "types": ["T044"], "canonical_name": "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine", "definition": "The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). [EC:2.1.1.44]"}
{"concept_id": "C3268404", "aliases": ["N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolism", "histidine betaine metabolism", "hercynine metabolism", "hercynine metabolic process", "histidine betaine metabolic process"], "types": ["T044"], "canonical_name": "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process", "definition": "The chemical reactions and pathways involving N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine. [GOC:curators]"}
{"concept_id": "C3268405", "aliases": ["histidine betaine biosynthetic process", "histidine betaine formation", "histidine betaine synthesis", "histidine betaine biosynthesis", "hercynine biosynthesis", "hercynine formation", "hercynine anabolism", "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine formation", "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine anabolism", "hercynine synthesis", "hercynine biosynthetic process", "histidine betaine anabolism", "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis", "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine synthesis"], "types": ["T044"], "canonical_name": "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine. [GOC:curators]"}
{"concept_id": "C3268406", "aliases": ["hercynine breakdown", "histidine betaine degradation", "hercynine catabolism", "hercynine catabolic process", "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine breakdown", "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism", "hercynine degradation", "histidine betaine breakdown", "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine degradation", "histidine betaine catabolism", "histidine betaine catabolic process"], "types": ["T044"], "canonical_name": "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine. [GOC:curators]"}
{"concept_id": "C3268408", "aliases": [], "types": ["T044"], "canonical_name": "inositol phosphosphingolipid phospholipase activity", "definition": "Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol. [GOC:ai]"}
{"concept_id": "C3268409", "aliases": [], "types": ["T044"], "canonical_name": "inositol phosphorylceramide phospholipase activity", "definition": "Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol. [GOC:ai]"}
{"concept_id": "C3268410", "aliases": [], "types": ["T044"], "canonical_name": "mannosyl-inositol phosphorylceramide phospholipase activity", "definition": "Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol. [GOC:ai]"}
{"concept_id": "C3268411", "aliases": [], "types": ["T044"], "canonical_name": "mannosyl-diinositol phosphorylceramide phospholipase activity", "definition": "Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol. [GOC:ai]"}
{"concept_id": "C3268412", "aliases": [], "types": ["T044"], "canonical_name": "laccase reaction"}
{"concept_id": "C3268413", "aliases": ["tRNA(Ala)-A34 deaminase activity"], "types": ["T045"], "canonical_name": "tRNA-specific adenosine-34 deaminase activity", "definition": "Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule. [PMID:17875641]"}
{"concept_id": "C3268414", "aliases": ["tRNA-A34 deaminase complex", "tRNA-specific adenosine-34 deaminase complex location", "tRNA-A34 deaminase complex location"], "types": ["T026"], "canonical_name": "tRNA-specific adenosine-34 deaminase complex", "definition": "A protein complex that possesses tRNA-specific adenosine-34 deaminase activity. In eukaryotes the complex is a heterodimer; the subunits are known as Tad2p and Tad3p in yeasts and Adat2 and Adat3 in human. [PMID:17875641]"}
{"concept_id": "C3268415", "aliases": ["abasic endoribonuclease activity", "AP endoribonuclease activity"], "types": ["T045"], "canonical_name": "apurinic/apyrimidinic endoribonuclease activity", "definition": "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends. [PMID:19401441]"}
{"concept_id": "C3268416", "aliases": [], "types": ["T045"], "canonical_name": "apurinic endoribonuclease activity"}
{"concept_id": "C3268417", "aliases": [], "types": ["T045"], "canonical_name": "apyrimidinic endoribonuclease activity"}
{"concept_id": "C3268418", "aliases": ["class II DNA-(apurinic or apyrimidinic site) lyase activity"], "types": ["T045"], "canonical_name": "class II DNA-(apurinic or apyrimidinic site) endonuclease activity", "definition": "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. [PMID:19401441]"}
{"concept_id": "C3268421", "aliases": ["regulation of AP endodeoxyribonuclease activity", "regulation of abasic endodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "regulation of apurinic/apyrimidinic endodeoxyribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of apurinic/apyrimidinic (AP) endodeoxyribonuclease activity, the hydrolysis of ester linkages immediately 5' to an AP (also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. [PMID:19401441]"}
{"concept_id": "C3268422", "aliases": [], "types": ["T044"], "canonical_name": "regulation of apurinic endodeoxyribonuclease activity"}
{"concept_id": "C3268423", "aliases": [], "types": ["T044"], "canonical_name": "regulation of apyrimidinic endodeoxyribonuclease activity"}
{"concept_id": "C3268424", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid in-chain hydroxylase activity", "definition": "Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O. [MetaCyc:RXN-12186]"}
{"concept_id": "C3268425", "aliases": [], "types": ["T044"], "canonical_name": "inositol hexakisphosphate 1-kinase activity", "definition": "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate. [GOC:jp, PMID:18981179, RHEA:37459]"}
{"concept_id": "C3268426", "aliases": [], "types": ["T044"], "canonical_name": "inositol hexakisphosphate 3-kinase activity", "definition": "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate. [GOC:jp, PMID:18981179]"}
{"concept_id": "C3268427", "aliases": [], "types": ["T044"], "canonical_name": "IP3 6-kinase activity"}
{"concept_id": "C3268429", "aliases": ["S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity", "dimethylglycine N-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine. [EC:2.1.1.157]", "canonical_name": "ApDMT"}
{"concept_id": "C3268430", "aliases": ["SDMT", "sarcosine N-methyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine. [EC:2.1.1.157]", "canonical_name": "S-adenosyl-L-methionine:N,N-sarcosine N-methyltransferase activity"}
{"concept_id": "C3268431", "aliases": ["quinate:NADP(+) 3-oxidoreductase activity", "quinate:NADP 3-oxidoreductase activity"], "types": ["T044"], "canonical_name": "quinate 3-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+. [RHEA:18425]"}
{"concept_id": "C3268432", "aliases": ["3-dehydroshikimic reductase activity", "3-dehydroshikimate reductase activity", "shikimate:NAD(P)(+) 3-oxidoreductase activity"], "types": ["T044"], "canonical_name": "shikimate 3-dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+. [RHEA:17741]"}
{"concept_id": "C3268433", "aliases": [], "types": ["T044"], "canonical_name": "shikimate:NAD(P)(+) oxidoreductase activity"}
{"concept_id": "C3268434", "aliases": ["tRNA cytosine-3-methyltransferase activity", "S-adenosyl-L-methionine:tRNA cytosine-3-methyltransferase activity", "transfer ribonucleate cytosine 3-methyltransferase activity", "tRNA cytosine 3-methyltransferase activity", "S-adenosyl-L-methionine:tRNA (cytosine-3-)-methyltransferase activity", "tRNA (cytosine 3)-methyltransferase activity"], "types": ["T045"], "canonical_name": "tRNA (cytosine-3-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine. [PMID:21518804, PMID:21518805]"}
{"concept_id": "C3268435", "aliases": ["pyruvate:ubiquinone-8-oxidoreductase activity", "pyruvate:ubiquinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "pyruvate dehydrogenase (quinone) activity", "definition": "Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2. [EC:1.2.5.1]"}
{"concept_id": "C3268436", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound. [EC:1.2.5.-]"}
{"concept_id": "C3268437", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylserine 1-acylhydrolase activity", "definition": "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid. [KEGG_REACTION:R04034]"}
{"concept_id": "C3268438", "aliases": [], "types": ["T044"], "canonical_name": "1-acyl-2-lysophosphatidylserine acylhydrolase activity", "definition": "Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate. [BRENDA:3.1.1.32]"}
{"concept_id": "C3268439", "aliases": [], "types": ["T044"], "canonical_name": "inositol tetrakisphosphate phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. [GOC:ai]"}
{"concept_id": "C3268440", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol monophosphate phosphatase activity", "definition": "Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. [GOC:ai]"}
{"concept_id": "C3268441", "aliases": [], "types": ["T044"], "canonical_name": "inositol phosphorylation", "definition": "The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms. [ISBN:0198506732]"}
{"concept_id": "C3268442", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol phosphorylation"}
{"concept_id": "C3268443", "aliases": ["sinapyl-alcohol dehydrogenase activity", "sinapyl-alcohol:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "sinapyl alcohol dehydrogenase activity", "definition": "Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+. [GOC:mengo_curators, MetaCyc:RXN-1125]"}
{"concept_id": "C3268444", "aliases": ["5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase activity"], "types": ["T044"], "canonical_name": "baicalin beta-D-glucuronidase activity", "definition": "Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate. [GOC:mengo_curators, RHEA:28130]"}
{"concept_id": "C3268445", "aliases": [], "types": ["T044"], "canonical_name": "baicalinase activity"}
{"concept_id": "C3268446", "aliases": ["D-glucose-6-phosphate:F420 1-oxidoreductase activity", "F420-dependent glucose-6-phosphate dehydrogenase activity", "coenzyme F420-dependent glucose-6-phosphate dehydrogenase activity"], "types": ["T044"], "canonical_name": "glucose-6-phosphate dehydrogenase (coenzyme F420) activity", "definition": "Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420. [EC:1.1.98.2, GOC:mengo_curators, RHEA:27294]"}
{"concept_id": "C3268447", "aliases": ["reactive-black-5:hydrogen-peroxide oxidoreductase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O. [KEGG_REACTION:R07612, MetaCyc:RXN-8666]", "canonical_name": "versatile peroxidase activity"}
{"concept_id": "C3268448", "aliases": [], "types": ["T044"], "canonical_name": "GDP-mannose hydrolase activity", "definition": "Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate. [PMID:16766526]"}
{"concept_id": "C3268449", "aliases": [], "types": ["T044"], "canonical_name": "GDP-mannose pyrophosphatase activity"}
{"concept_id": "C3268450", "aliases": ["F420H2:heterodisulfide oxidoreductase activity", "F420-dependent heterodisulfide oxidoreductase activity", "coenzyme F420-dependent heterodisulfide oxidoreductase activity"], "types": ["T044"], "canonical_name": "reduced coenzyme F420:heterodisulfide oxidoreductase activity", "definition": "Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH. [GOC:mengo_curators, PMID:9914308]"}
{"concept_id": "C3268451", "aliases": ["isopropanol:coenzyme F420 oxidoreductase activity", "F420-dependent propan-2-ol dehydrogenase activity"], "types": ["T044"], "canonical_name": "propan-2-ol:coenzyme F420 oxidoreductase activity", "definition": "Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420. [GOC:mengo_curators, PMID:15016352, PMID:1879431, PMID:8706724]"}
{"concept_id": "C3268452", "aliases": [], "types": ["T044"], "canonical_name": "F420-dependent secondary alcohol dehydrogenase activity"}
{"concept_id": "C3268453", "aliases": ["GTP:coenzyme F420 guanylyltransferase activity", "coenzyme F390-G synthetase activity"], "types": ["T044"], "canonical_name": "GTP:coenzyme F420 guanyltransferase activity", "definition": "Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate. [GOC:mengo_curators, MetaCyc:MONOMER-13942, MetaCyc:RXN-9385]"}
{"concept_id": "C3268454", "aliases": ["F420H2:2,3-dimethyl-1,4-naphthoquinone oxidoreductase activity", "F420H2:quinone oxidoreductase activity", "F420H2-dependent quinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "reduced coenzyme F420:quinone oxidoreductase activity", "definition": "Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone. [GOC:mengo_curators, PMID:10971593, PMID:8055920]"}
{"concept_id": "C3268455", "aliases": [], "types": ["T044"], "canonical_name": "chitobiose phosphorylase activity", "definition": "Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units. [GOC:mengo_curators, PMID:15274915, Wikipedia:chitobiose]"}
{"concept_id": "C3268456", "aliases": ["chondroitin endo-beta-galactosaminidase activity"], "types": ["T044"], "canonical_name": "chondroitin hydrolase activity", "definition": "Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]. [GOC:mengo_curators, PMID:18390555]"}
{"concept_id": "C3268457", "aliases": ["coenzyme F420-dependent 2,4,6-trinitrophenol hydride transferase activity"], "types": ["T044"], "canonical_name": "coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity", "definition": "Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction. [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1065]"}
{"concept_id": "C3268458", "aliases": [], "types": ["T044"], "canonical_name": "TNP reductase activity"}
{"concept_id": "C3268459", "aliases": ["coenzyme F420-dependent 2,4,6-trinitrophenol-hydride-Meisenheimer-complex hydride transferase activity"], "types": ["T044"], "canonical_name": "coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity", "definition": "Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction. [GOC:mengo_curators, UM-BBD_reactionID:r1066]"}
{"concept_id": "C3268460", "aliases": ["coenzyme F420-dependent 2,4-dinitrophenol hydride transferase activity"], "types": ["T044"], "canonical_name": "coenzyme F420-dependent 2,4-dinitrophenol reductase activity", "definition": "Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction. [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1071]"}
{"concept_id": "C3268461", "aliases": [], "types": ["T044"], "canonical_name": "DNP reductase activity"}
{"concept_id": "C3268462", "aliases": ["exochitosanase activity", "chitosan exo-1,4-beta-D-glucosaminidase activity", "chitosan glucosaminohydrolase activity", "exo-beta-D-glucosaminidase activity"], "types": ["T044"], "canonical_name": "exo-1,4-beta-D-glucosaminidase activity", "definition": "Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units. [EC:3.2.1.165, GOC:mengo_curators, MetaCyc:3.2.1.165-RXN]"}
{"concept_id": "C3268463", "aliases": [], "types": ["T044"], "canonical_name": "gellan lyase activity", "definition": "Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha). [GOC:mengo_curators, MetaCyc:RXN-12269]"}
{"concept_id": "C3268464", "aliases": [], "types": ["T044"], "canonical_name": "ulvan lyase activity", "definition": "Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end. [GOC:mengo_curators, PMID:9468631]"}
{"concept_id": "C3268465", "aliases": [], "types": ["T044"], "canonical_name": "exo-oligoalginate lyase activity", "definition": "Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. [GOC:mengo_curators, PMID:20925655]"}
{"concept_id": "C3268466", "aliases": ["F420H2:oxygen oxidoreductase activity", "coenzyme F420H2 oxidase activity", "F420H2 oxidase activity"], "types": ["T044"], "canonical_name": "reduced coenzyme F420 oxidase activity", "definition": "Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O. [GOC:mengo_curators, PMID:15340796]"}
{"concept_id": "C3268467", "aliases": ["mannoside alpha-1,4-exomannosidase activity", "mannoside exo-alpha-1,4-mannosidase activity"], "types": ["T044"], "canonical_name": "mannoside alpha-1,4-mannosidase activity", "definition": "Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. [GOC:mengo_curators, PMID:20081828]"}
{"concept_id": "C3268468", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1,4-exomannosidase activity"}
{"concept_id": "C3268469", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1,4-mannosidase activity"}
{"concept_id": "C3268470", "aliases": ["1,6-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity", "alpha-1,6-mannosyl-oligosaccharide alpha-D-mannohydrolase activity"], "types": ["T044"], "canonical_name": "mannosyl-oligosaccharide 1,6-alpha-mannosidase activity", "definition": "Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide. [GOC:mengo_curators, PMID:1849817, PMID:2338081]"}
{"concept_id": "C3268471", "aliases": ["alpha-1,6-mannosidase activity"], "types": ["T044"], "canonical_name": "1,6-alpha-mannosidase activity"}
{"concept_id": "C3268472", "aliases": ["alpha-1,3-mannosyl-oligosaccharide alpha-D-mannohydrolase activity", "1,3-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity"], "types": ["T044"], "canonical_name": "mannosyl-oligosaccharide 1,3-alpha-mannosidase activity", "definition": "Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide. [GOC:mengo_curators, PMID:1849817, PMID:2338081]"}
{"concept_id": "C3268473", "aliases": ["alpha-1,3-mannosidase activity"], "types": ["T044"], "canonical_name": "1,3-alpha-mannosidase activity"}
{"concept_id": "C3268474", "aliases": ["sulfomucin beta-6-sulfate-N-acetylglucosaminidase activity"], "types": ["T044"], "canonical_name": "beta-6-sulfate-N-acetylglucosaminidase activity", "definition": "Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative. [GOC:mengo_curators, PMID:15716424]"}
{"concept_id": "C3268475", "aliases": [], "types": ["T044"], "canonical_name": "beta-6-SO3-N-acetylglucosaminidase activity"}
{"concept_id": "C3268476", "aliases": [], "types": ["T044"], "canonical_name": "exosulfoglycosidase activity"}
{"concept_id": "C3268477", "aliases": [], "types": ["T044"], "canonical_name": "sulfoglycosidase activity"}
{"concept_id": "C3268478", "aliases": ["8-hydroxyadenylylated-coenzyme F420 hydrolase activity"], "types": ["T044"], "canonical_name": "coenzyme F390-A hydrolase activity", "definition": "Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420. [GOC:mengo_curators, PMID:8536708, PMID:9352911]"}
{"concept_id": "C3268479", "aliases": ["8-hydroxyguanylylated-coenzyme F420 hydrolase activity"], "types": ["T044"], "canonical_name": "coenzyme F390-G hydrolase activity", "definition": "Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420. [GOC:mengo_curators, PMID:8536708, PMID:9352911]"}
{"concept_id": "C3268480", "aliases": ["brefeldin A hydrolase activity", "BFA esterase activity"], "types": ["T044"], "canonical_name": "brefeldin A esterase activity", "definition": "Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone. [GOC:mengo_curators, PMID:10201402, PMID:8106385]"}
{"concept_id": "C3268482", "aliases": ["N,N'-diacetylchitobiose deacetylase (nonreducing end)"], "types": ["T044"], "canonical_name": "diacetylchitobiose deacetylase activity", "definition": "Catalysis of the reaction: N,N'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc). [GOC:bf, GOC:mengo_curators, MetaCyc:RXN-12543, PMID:15136574, PMID:16232910, PMID:16736587]"}
{"concept_id": "C3268483", "aliases": [], "types": ["T044"], "canonical_name": "glucosyl-N-acetylglucosamine glucosaminidase activity", "definition": "Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine. [GOC:mengo_curators, PMID:15136574, PMID:16232910, PMID:16736587]"}
{"concept_id": "C3268484", "aliases": ["endo-(1->3)-alpha-L-rhamnosidase activity", "endo-(1,3)-alpha-L-rhamnosidase activity"], "types": ["T044"], "canonical_name": "endo-1,3-alpha-L-rhamnosidase activity", "definition": "Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain. [GOC:mengo_curators, PMID:10439404]"}
{"concept_id": "C3268485", "aliases": [], "types": ["T044"], "canonical_name": "endorhamnosidase activity"}
{"concept_id": "C3268486", "aliases": [], "types": ["T044"], "canonical_name": "diacetylchitobiose catabolic process to glucosamine and acetate", "definition": "The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate. [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587]"}
{"concept_id": "C3268487", "aliases": ["diacetylchitobiose catabolism"], "types": ["T044"], "canonical_name": "diacetylchitobiose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of diacetylchitobiose into simpler products. [PMID:22797760]"}
{"concept_id": "C3268488", "aliases": ["diacetylchitobiose metabolism"], "types": ["T044"], "canonical_name": "diacetylchitobiose metabolic process", "definition": "The chemical reactions and pathways involving diacetylchitobiose, the N,N'-diacetylated derivative of chitobiose. [PMID:22797760]"}
{"concept_id": "C3268489", "aliases": [], "types": ["T044"], "canonical_name": "amino disaccharide metabolic process", "definition": "The chemical reactions and pathways involving any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions. [GOC:curators]"}
{"concept_id": "C3268490", "aliases": [], "types": ["T044"], "canonical_name": "chitobiose metabolic process", "definition": "The chemical reactions and pathways involving chitobioses, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine. [GOC:curators]"}
{"concept_id": "C3268491", "aliases": [], "types": ["T044"], "canonical_name": "chitobiose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine. [GOC:curators]"}
{"concept_id": "C3268492", "aliases": [], "types": ["T044"], "canonical_name": "amino disaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions. [GOC:curators]"}
{"concept_id": "C3268493", "aliases": [], "types": ["T044"], "canonical_name": "reuteran metabolic process", "definition": "The chemical reactions and pathways involving reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages. [PMID:15256553, PMID:16000808]"}
{"concept_id": "C3268494", "aliases": [], "types": ["T044"], "canonical_name": "reuteran biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages. [GOC:mengo_curators, PMID:15256553, PMID:16000808]"}
{"concept_id": "C3268495", "aliases": [], "types": ["T044"], "canonical_name": "reuteransucrase-mediated reuteran biosynthesis"}
{"concept_id": "C3268496", "aliases": [], "types": ["T044"], "canonical_name": "cellulose catabolism by endo-processive cellulases", "definition": "The breakdown into simpler components of cellulose. Catabolism is initiated by endohydrolytic attacks on the cellulose chain, and the resulting pieces are further degraded by cellulase enzymes to produce smaller and smaller fragments. [GOC:mengo_curators, PMID:18035374]"}
{"concept_id": "C3268497", "aliases": [], "types": ["T044"], "canonical_name": "endo-processive cellulase activity"}
{"concept_id": "C3268498", "aliases": ["alpha-amylase-mediated polysaccharide catabolism, producing maltotriose"], "types": ["T044"], "canonical_name": "alpha-linked polysaccharide catabolism to maltotriose", "definition": "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltotriose. [GOC:mengo_curators, PMID:7511484, PMID:9406414]"}
{"concept_id": "C3268499", "aliases": [], "types": ["T044"], "canonical_name": "maltotriose-forming alpha-amylase activity"}
{"concept_id": "C3268500", "aliases": ["alpha-amylase-mediated polysaccharide catabolism, producing maltopentaose"], "types": ["T044"], "canonical_name": "alpha-linked polysaccharide catabolism to maltopentaose", "definition": "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltopentaose. [GOC:mengo_curators, PMID:7511484, PMID:9406414]"}
{"concept_id": "C3268501", "aliases": [], "types": ["T044"], "canonical_name": "maltopentaose-forming alpha-amylase activity"}
{"concept_id": "C3268502", "aliases": ["unsaturated beta-glucuronyl hydrolase activity"], "types": ["T044"], "canonical_name": "d-4,5 unsaturated beta-glucuronyl hydrolase activity", "definition": "Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue. [GOC:mengo_curators, PMID:12729728]"}
{"concept_id": "C3268503", "aliases": ["exo-beta-1,3-mannase activity", "exo-1,3-beta-mannanase activity", "beta-1,3-mannan 3-mannanohydrolase activity", "exo-1,3-mannanase activity", "1,3-beta-D-mannan mannanohydrolase activity"], "types": ["T044"], "canonical_name": "mannan 1,3-beta-mannosidase activity", "definition": "Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose. [EC:3.2.1.78, GOC:mengo_curators]"}
{"concept_id": "C3268504", "aliases": [], "types": ["T044"], "canonical_name": "chitooligosaccharide deacetylase activity", "definition": "Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions. [GOC:mengo_curators, PMID:8421697, PMID:8986807]"}
{"concept_id": "C3268505", "aliases": ["2-keto-3-deoxynononic acid sialidase activity"], "types": ["T044"], "canonical_name": "3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity", "definition": "Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain. [GOC:mengo_curators, PMID:21247893]"}
{"concept_id": "C3268506", "aliases": [], "types": ["T044"], "canonical_name": "endo-xylogalacturonan hydrolase activity", "definition": "Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position. [GOC:mengo_curators, PMID:10618200]"}
{"concept_id": "C3268507", "aliases": [], "types": ["T044"], "canonical_name": "endo-galacturonase activity"}
{"concept_id": "C3268508", "aliases": [], "types": ["T044"], "canonical_name": "pectin acetylesterase activity", "definition": "Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin. [GOC:mengo_curators, PMID:9218776]"}
{"concept_id": "C3268509", "aliases": ["exo-alpha-2,3-sialidase activity", "exo-alpha-(2,3)-sialidase activity"], "types": ["T044"], "canonical_name": "exo-alpha-(2->3)-sialidase activity", "definition": "Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators]"}
{"concept_id": "C3268510", "aliases": ["exo-alpha-(2,6)-sialidase activity", "exo-alpha-2,6-sialidase activity"], "types": ["T044"], "canonical_name": "exo-alpha-(2->6)-sialidase activity", "definition": "Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators]"}
{"concept_id": "C3268511", "aliases": ["exo-alpha-2,8-sialidase activity", "exo-alpha-(2,8)-sialidase activity"], "types": ["T044"], "canonical_name": "exo-alpha-(2->8)-sialidase activity", "definition": "Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators]"}
{"concept_id": "C3268512", "aliases": [], "types": ["T044"], "canonical_name": "4-O-methyl-glucuronoyl methylesterase activity", "definition": "Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]. [GOC:mengo_curators, PMID:16876163]"}
{"concept_id": "C3268513", "aliases": [], "types": ["T044"], "canonical_name": "glucuronoyl esterase activity"}
{"concept_id": "C3268514", "aliases": [], "types": ["T044"], "canonical_name": "trans-sialidase activity"}
{"concept_id": "C3268515", "aliases": ["coenzyme F420-dependent nitroimidazole reduction", "coenzyme F420-dependent nitroimidazole breakdown", "coenzyme F420-dependent nitroimidazole catabolism"], "types": ["T044"], "canonical_name": "coenzyme F420-dependent bicyclic nitroimidazole catabolic process", "definition": "The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates. [GOC:mengo_curators, PMID:16387854, PMID:19039139]"}
{"concept_id": "C3268516", "aliases": [], "types": ["T044"], "canonical_name": "coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3268517", "aliases": ["bicyclic nitroimidazole catabolism", "bicyclic nitroimidazole degradation", "bicyclic nitroimidazole breakdown"], "types": ["T044"], "canonical_name": "bicyclic nitroimidazole catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a bicyclic nitroimidazole. [PMID:16387854, PMID:19039139]"}
{"concept_id": "C3268518", "aliases": ["bicyclic nitroimidazole metabolism"], "types": ["T044"], "canonical_name": "bicyclic nitroimidazole metabolic process", "definition": "The chemical reactions and pathways involving bicyclic nitroimidazoles, imidazole derivatives with two rings and a nitro group attached to one ring. [PMID:16387854, PMID:19039139]"}
{"concept_id": "C3268519", "aliases": ["nitroimidazole metabolism"], "types": ["T044"], "canonical_name": "nitroimidazole metabolic process", "definition": "The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring. [PMID:16387854, PMID:19039139]"}
{"concept_id": "C3268520", "aliases": ["imidazole metabolism"], "types": ["T044"], "canonical_name": "imidazole-containing compound metabolic process", "definition": "The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. [GOC:curators]"}
{"concept_id": "C3268521", "aliases": ["nitroimidazole breakdown", "nitroimidazole catabolism", "nitroimidazole degradation"], "types": ["T044"], "canonical_name": "nitroimidazole catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nitroimidazoles, imidazole derivatives with a nitro group attached to one ring. [PMID:16387854, PMID:19039139]"}
{"concept_id": "C3268522", "aliases": ["imidazole catabolism", "imidazole degradation", "imidazole breakdown"], "types": ["T044"], "canonical_name": "imidazole-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. [GOC:curators]"}
{"concept_id": "C3268523", "aliases": ["hydrogen-sulfide:coenzyme F420 oxidoreductase activity", "sulfite:reduced coenzyme F420 reductase activity", "coenzyme F420-dependent sulfite reductase activity", "coenzyme F420-sulfite reductase activity"], "types": ["T044"], "canonical_name": "sulfite reductase (coenzyme F420) activity", "definition": "Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. [GOC:mengo_curators, PMID:16048999]"}
{"concept_id": "C3268524", "aliases": ["coenzyme F420-dependent aflatoxin reductase activity", "aflatoxin:coenzyme F420 oxidoreductase activity", "coenzyme F420-aflatoxin reductase activity", "aflatoxin:reduced coenzyme F420 reductase activity"], "types": ["T044"], "canonical_name": "aflatoxin reductase (coenzyme F420) activity", "definition": "Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. [GOC:mengo_curators, PMID:20807200]"}
{"concept_id": "C3268525", "aliases": ["coenzyme F420-dependent NADP reductase activity", "NADP+:F420 oxidoreductase activity", "F420H2:NADP+ oxidoreductase activity", "coenzyme F420-dependent NADP oxidoreductase activity", "F420H2:NADP oxidoreductase activity"], "types": ["T044"], "canonical_name": "reduced coenzyme F420:NADP+ oxidoreductase activity", "definition": "Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. [GOC:mengo_curators, PMID:11726492]"}
{"concept_id": "C3268526", "aliases": [], "types": ["T044"], "canonical_name": "acharan sulfate lyase activity", "definition": "Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid. [GOC:mengo_curators, PMID:19566715]"}
{"concept_id": "C3268527", "aliases": ["ATP:1-phosphatidyl-1D-myo-inositol 5-phosphotransferase activity", "1-phosphatidylinositol 5-kinase activity"], "types": ["T044"], "canonical_name": "1-phosphatidylinositol-5-kinase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H(+). [PMID:12270933, PMID:9660759, RHEA:44680]"}
{"concept_id": "C3268528", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol bisphosphate kinase activity", "definition": "Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol trisphosphate. [GOC:ai]"}
{"concept_id": "C3268529", "aliases": ["medium-chain aliphatic aldehyde dehydrogenase activity", "medium-chain fatty aldehyde dehydrogenase activity", "medium-chain-aldehyde:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "medium-chain-aldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons. [EC:1.2.1.48]"}
{"concept_id": "C3268530", "aliases": ["long-chain acyl coenzyme A hydrolase activity", "long-chain hydrolase activity", "long-chain acyl-thioester hydrolase activity", "long-chain-acyl-CoA hydrolase activity"], "types": ["T044"], "canonical_name": "long-chain acyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length. [EC:3.1.2.19]"}
{"concept_id": "C3268531", "aliases": ["very long-chain acyl-thioester hydrolase activity", "very long-chain acyl coenzyme A hydrolase activity", "very long-chain-acyl-CoA hydrolase activity", "very long-chain hydrolase activity"], "types": ["T044"], "canonical_name": "very long chain acyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18. [EC:3.1.2.19]"}
{"concept_id": "C3268532", "aliases": ["guanosine diphosphomannose-heteroglycan 3-alpha-mannosyltransferase activity", "heteropolysaccharide 3-alpha-mannosyltransferase activity", "GDP-mannose:heteroglycan 3-alpha-D-mannosyltransferase activity", "GDP mannose 3-alpha-mannosyltransferase activity"], "types": ["T044"], "canonical_name": "heteroglycan 3-alpha-mannosyltransferase activity", "definition": "Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP. [EC:2.4.1.48, MetaCyc:RXN-7992]"}
{"concept_id": "C3268533", "aliases": ["GDP-mannose:heteroglycan 2-alpha-D-mannosyltransferase activity", "guanosine diphosphomannose-heteroglycan 2-alpha-mannosyltransferase activity", "heteropolysaccharide 2-alpha-mannosyltransferase activity", "GDP mannose 2-alpha-mannosyltransferase activity"], "types": ["T044"], "canonical_name": "heteroglycan 2-alpha-mannosyltransferase activity", "definition": "Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP. [EC:2.4.1.48, MetaCyc:2.4.1.48-RXN]"}
{"concept_id": "C3268534", "aliases": ["1,N6-ethenoadenine glycosylase activity", "1,N(6)-ethenoadenine N-glycosylase activity"], "types": ["T045"], "canonical_name": "DNA-1,N6-ethenoadenine N-glycosylase activity", "definition": "Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. [PMID:21960007]"}
{"concept_id": "C3268535", "aliases": [], "types": ["T045"], "canonical_name": "DNA-7-methyladenine glycosylase activity", "definition": "Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site. [GOC:jl, PMID:16468998]"}
{"concept_id": "C3268536", "aliases": [], "types": ["T045"], "canonical_name": "DNA-3-methylguanine glycosylase activity", "definition": "Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site. [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623]"}
{"concept_id": "C3268537", "aliases": [], "types": ["T045"], "canonical_name": "3-methylguanine DNA glycosylase I"}
{"concept_id": "C3268538", "aliases": [], "types": ["T045"], "canonical_name": "deoxyribonucleate 3-methylguanine glycosidase I"}
{"concept_id": "C3268539", "aliases": ["(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate fumarylhydrolase activity", "2-hydroxy-6-ketonona-2,4,7-trienedoic acid hydrolase activity"], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity", "definition": "Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+. [RHEA:25046]"}
{"concept_id": "C3268541", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity", "definition": "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate. [GOC:ai]"}
{"concept_id": "C3268542", "aliases": ["1D-myo-inositol-hexakisphosphate 2-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "inositol hexakisphosphate 2-phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate. [EC:3.1.3.62]"}
{"concept_id": "C3268543", "aliases": [], "types": ["T044"], "canonical_name": "inositol pentakisphosphate phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate. [GOC:bf]"}
{"concept_id": "C3268544", "aliases": [], "types": ["T044"], "canonical_name": "inositol-3,4-bisphosphate 4-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate. [GOC:mah]"}
{"concept_id": "C3268545", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,3,4-trisphosphate 1-phosphatase activity", "definition": "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate. [GOC:ai]"}
{"concept_id": "C3268546", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity", "definition": "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate. [GOC:ai]"}
{"concept_id": "C3268547", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity", "definition": "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate. [GOC:ai]"}
{"concept_id": "C3268548", "aliases": [], "types": ["T044"], "canonical_name": "inositol monophosphate 3-phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate. [EC:3.1.3.25]"}
{"concept_id": "C3268549", "aliases": [], "types": ["T044"], "canonical_name": "inositol monophosphate 4-phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate. [EC:3.1.3.25]"}
{"concept_id": "C3268550", "aliases": ["ATP:1D-myo-inositol-3,4,6-trisphosphate 1-phosphotransferase activity", "inositol 3,4,6-trisphosphate 1-kinase activity", "Ins(3,4,6)P3 1-kinase activity", "ins(3,4,6)P(3) 1-kinase activity"], "types": ["T044"], "canonical_name": "inositol-3,4,6-trisphosphate 1-kinase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+). [GOC:curators]"}
{"concept_id": "C3268551", "aliases": [], "types": ["T044"], "canonical_name": "1D-myo-inositol-trisphosphate 1-kinase activity"}
{"concept_id": "C3268553", "aliases": ["inositol-trisphosphate 1-kinase activity"], "types": ["T044"], "canonical_name": "IP3 1-kinase activity"}
{"concept_id": "C3268554", "aliases": [], "types": ["T044"], "canonical_name": "inositol 5-diphosphate pentakisphosphate 5-kinase activity", "definition": "Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate. [PMID:11502751, PMID:18355727]"}
{"concept_id": "C3268555", "aliases": ["thiazole formation", "thiazole anabolism", "thiazole synthesis", "thiazole biosynthesis"], "types": ["T044"], "canonical_name": "thiazole biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position. [GOC:curators]"}
{"concept_id": "C3268556", "aliases": ["thiazole metabolism"], "types": ["T044"], "canonical_name": "thiazole metabolic process", "definition": "The chemical reactions and pathways involving thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position. [GOC:curators]"}
{"concept_id": "C3268557", "aliases": [], "types": ["T044"], "canonical_name": "inositol diphosphate tetrakisphosphate kinase activity", "definition": "Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate. [PMID:10827188, PMID:11502751, PMID:18355727]"}
{"concept_id": "C3268558", "aliases": [], "types": ["T044"], "canonical_name": "inositol diphosphate tetrakisphosphate diphosphatase activity", "definition": "Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate. [MetaCyc:RXN-10963, PMID:10827188, PMID:11502751]"}
{"concept_id": "C3268559", "aliases": [], "types": ["T044"], "canonical_name": "inositol bisdiphosphate tetrakisphosphate diphosphatase activity", "definition": "Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate. [MetaCyc:RXN-10965, MetaCyc:RXN-10975, MetaCyc:RXN-10976, PMID:10827188, PMID:11502751]"}
{"concept_id": "C3268560", "aliases": [], "types": ["T044"], "canonical_name": "inositol diphosphate pentakisphosphate diphosphatase activity", "definition": "Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate. [MetaCyc:RXN-10964, MetaCyc:RXN-10977, MetaCyc:RXN-10978, PMID:10827188, PMID:11502751]"}
{"concept_id": "C3268561", "aliases": ["inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity", "inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity"], "types": ["T044"], "canonical_name": "inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity", "definition": "Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. [MetaCyc:RXN-10977, PMID:10827188, PMID:11502751]"}
{"concept_id": "C3268562", "aliases": ["inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity", "inositol 1,5-bispyrophosphate 2,3,4,6-tetrakisphosphate 1-pyrophosphatase activity"], "types": ["T044"], "canonical_name": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity", "definition": "Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+. [MetaCyc:RXN-10965, PMID:10827188, PMID:11502751]"}
{"concept_id": "C3268563", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "definition": "Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+. [MetaCyc:RXN-10975, PMID:10827188, PMID:11502751]"}
{"concept_id": "C3268564", "aliases": [], "types": ["T044"], "canonical_name": "inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "definition": "Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+. [MetaCyc:RXN-10976, PMID:10827188, PMID:11502751]"}
{"concept_id": "C3268565", "aliases": [], "types": ["T044"], "canonical_name": "NADPH-dependent curcumin reductase activity", "definition": "Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+. [MetaCyc:RXN0-6676]"}
{"concept_id": "C3268566", "aliases": ["dihydrocurcumin reductase (NADPH) activity"], "types": ["T044"], "canonical_name": "NADPH-dependent dihydrocurcumin reductase activity", "definition": "Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+. [MetaCyc:RXN0-6677]"}
{"concept_id": "C3268567", "aliases": ["ferric reductase, NADPH-dependent activity"], "types": ["T044"], "canonical_name": "ferric-chelate reductase (NADPH) activity", "definition": "Catalysis of the reaction: 2 Fe3+-siderophore + NADP(+) + H(+) -> 2 Fe2+-siderophore + NADPH. [RHEA:28795]"}
{"concept_id": "C3268580", "aliases": ["ADP-dependent H4NAD(P)OH dehydratase activity", "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)", "ADP-dependent H(4)NAD(P)OH dehydratase activity"], "types": ["T044"], "canonical_name": "ADP-dependent NAD(P)H-hydrate dehydratase activity", "definition": "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H(+) + NADH + phosphate. [EC:4.2.1.93, PMID:21994945]"}
{"concept_id": "C3268581", "aliases": [], "types": ["T044"], "canonical_name": "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)"}
{"concept_id": "C3268582", "aliases": [], "types": ["T044"], "canonical_name": "NADHX epimerase activity", "definition": "Catalysis of the reaction: (R)-NADHX = (S)-NADHX. [PMID:21994945]"}
{"concept_id": "C3268583", "aliases": [], "types": ["T044"], "canonical_name": "NADPHX epimerase activity", "definition": "Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX. [PMID:21994945]"}
{"concept_id": "C3268584", "aliases": ["peptidyl-lysine N(6)-acetyltransferase activity", "acetyl-phosphate:peptidyl-L-lysine N6-acetyltransferase activity", "peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "peptidyl-lysine N6-acetyltransferase activity", "acetyl-phosphate:peptidyl-L-lysine 6-N-acetyltransferase activity"], "types": ["T044"], "canonical_name": "peptidyl-lysine acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine. [GOC:tb]"}
{"concept_id": "C3268585", "aliases": ["2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity"], "types": ["T044"], "canonical_name": "2'-deoxymugineic-acid 3-dioxygenase activity", "definition": "Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2. [EC:1.14.11.25]"}
{"concept_id": "C3268586", "aliases": ["1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity"], "types": ["T044"], "canonical_name": "glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group", "definition": "Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. [EC:3.2.1.6]"}
{"concept_id": "C3268587", "aliases": ["1-deoxy-D-xylulose 5-phosphate metabolism", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolic process", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolism"], "types": ["T044"], "canonical_name": "1-deoxy-D-xylulose 5-phosphate metabolic process", "definition": "The chemical reactions and pathways involving 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. [GOC:curators]"}
{"concept_id": "C3268588", "aliases": ["(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolism", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate breakdown", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolic process", "1-deoxy-D-xylulose 5-phosphate breakdown", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate degradation", "1-deoxy-D-xylulose 5-phosphate catabolism", "1-deoxy-D-xylulose 5-phosphate degradation"], "types": ["T044"], "canonical_name": "1-deoxy-D-xylulose 5-phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. [GOC:curators]"}
{"concept_id": "C3268589", "aliases": ["1-deoxy-D-xylulose 5-phosphate formation", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate formation", "1-deoxy-D-xylulose 5-phosphate anabolism", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthesis", "1-deoxy-D-xylulose 5-phosphate biosynthesis", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate anabolism", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthetic process", "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate synthesis", "1-deoxy-D-xylulose 5-phosphate synthesis"], "types": ["T044"], "canonical_name": "1-deoxy-D-xylulose 5-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. [GOC:curators]"}
{"concept_id": "C3268590", "aliases": ["phosphoinositide phosphatase activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphate phosphatase activity", "definition": "Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. [GOC:ai]"}
{"concept_id": "C3268591", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate. [GOC:curators]"}
{"concept_id": "C3268592", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity"}
{"concept_id": "C3268594", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-trisphosphatase activity"}
{"concept_id": "C3268595", "aliases": ["phosphatidylinositol 1,4,5-trisphosphate phosphatase activity", "PtdIns(1,4,5)P3 phosphatase activity"], "types": ["T044"], "canonical_name": "PtdIns(1,4,5)P(3) phosphatase activity"}
{"concept_id": "C3268597", "aliases": [], "types": ["T044"], "canonical_name": "protein-lysine lysyltransferase activity", "definition": "Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine. [PMID:20729861]"}
{"concept_id": "C3268598", "aliases": ["arachidonic acid:oxygen 1-oxidoreductase activity"], "types": ["T044"], "canonical_name": "arachidonic acid omega-hydroxylase activity", "definition": "Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid. [KEGG_REACTION:R07041]"}
{"concept_id": "C3268599", "aliases": [], "types": ["T044"], "canonical_name": "arachidonic acid hydroxylase activity"}
{"concept_id": "C3268600", "aliases": ["tocopherol 13-hydroxylase activity"], "types": ["T044"], "canonical_name": "tocopherol omega-hydroxylase activity", "definition": "Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O . [MetaCyc:RXN-11003]"}
{"concept_id": "C3268601", "aliases": ["alpha-tocopherol 13-hydroxylase activity"], "types": ["T044"], "canonical_name": "alpha-tocopherol omega-hydroxylase activity", "definition": "Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O . [MetaCyc:RXN-11003]"}
{"concept_id": "C3268602", "aliases": ["tocotrienol 13-hydroxylase activity"], "types": ["T044"], "canonical_name": "tocotrienol omega-hydroxylase activity", "definition": "Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O . [MetaCyc:RXN-11003]"}
{"concept_id": "C3268603", "aliases": ["NAD(P)H:riboflavin oxidoreductase activity", "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide) reductase activity"], "types": ["T044"], "canonical_name": "riboflavin reductase (NADH) activity", "definition": "Catalysis of the reaction: reduced riboflavin + NAD+ = riboflavin + NADH + 2 H+. [RHEA:31455]"}
{"concept_id": "C3268604", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)H2 dehydrogenase (FMN) activity"}
{"concept_id": "C3268605", "aliases": ["methylamine:amicyanin oxidoreductase (deaminating) activity", "methylamine dehydrogenase activity"], "types": ["T044"], "canonical_name": "methylamine dehydrogenase (amicyanin) activity", "definition": "Catalysis of the reaction: 2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H+ + NH4+ + 2 reduced [amicyanin]. [RHEA:30207]"}
{"concept_id": "C3268609", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor. [GOC:ai]"}
{"concept_id": "C3268610", "aliases": [], "types": ["T044"], "canonical_name": "linoleate 8R-lipoxygenase activity", "definition": "Catalysis of the reaction: O(2) + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate. [RHEA:25395]"}
{"concept_id": "C3268611", "aliases": ["5,8-linoleate diol synthase (bifunctional enzyme) activity"], "types": ["T044"], "canonical_name": "5,8-LDS (bifunctional enzyme) activity"}
{"concept_id": "C3268613", "aliases": ["7,8-linoleate diol synthase (bifunctional enzyme) activity"], "types": ["T044"], "canonical_name": "7,8-LDS (bifunctional enzyme) activity"}
{"concept_id": "C3268615", "aliases": ["(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming) activity"], "types": ["T044"], "canonical_name": "9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity", "definition": "Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate. [RHEA:25399]"}
{"concept_id": "C3268616", "aliases": [], "types": ["T044"], "canonical_name": "8-hydroperoxide isomerase activity"}
{"concept_id": "C3268617", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein. [GOC:jl]"}
{"concept_id": "C3268618", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetic acid-3-hydroxylase activity"}
{"concept_id": "C3268619", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein. [GOC:jl]"}
{"concept_id": "C3268620", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity", "definition": "Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate. [RHEA:31775]"}
{"concept_id": "C3268621", "aliases": ["all-trans-retinol isomerase:hydrolase activity"], "types": ["T044"], "canonical_name": "all-trans-retinol isomerase:hydrolase activity"}
{"concept_id": "C3268622", "aliases": ["retinoid isomerohydrolase activity"], "types": ["T044"], "canonical_name": "retinoid isomerohydrolase activity"}
{"concept_id": "C3268623", "aliases": ["all-trans-retinyl ester acylhydrolase, 11-cis retinol forming activity", "all-trans-retinylester 11-cis isomerohydrolase activity"], "types": ["T044"], "canonical_name": "all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity", "definition": "Catalysis of the reaction: H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid. [RHEA:31771]"}
{"concept_id": "C3268624", "aliases": [], "types": ["T044"], "canonical_name": "9,9'-dicis-carotene:quinone oxidoreductase activity", "definition": "Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol. [RHEA:30959]"}
{"concept_id": "C3268625", "aliases": ["7,9,7',9'-tetra-cis-lycopene biosynthesis from 9,9'-di-cis-zeta-carotene", "9,9'-di-cis-zeta-carotene desaturase activity", "9,9'-di-cis-zeta-carotene catabolism to 7,9,7',9'-tetra-cis-lycopene"], "types": ["T044"], "canonical_name": "9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene", "definition": "The series of reactions in which 9,9'-di-cis-zeta-carotene is desaturated to 7,9,9'-tri-cis-neurosporene, and then 7,9,7',9'-tetra-cis-lycopene. The overall reaction for this process is: 9,9'-di-cis-zeta-carotene + 2 quinone = 2 quinol + 7,9,7',9'-tetra-cis-lycopene. [EC:1.3.5.6, KEGG_REACTION:R07511]"}
{"concept_id": "C3268626", "aliases": ["ZDS activity"], "types": ["T044"], "canonical_name": "ZDS activity"}
{"concept_id": "C3268627", "aliases": [], "types": ["T044"], "canonical_name": "7,9,9'-tricis-neurosporene:quinone oxidoreductase activity", "definition": "Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol. [EC:1.3.5.6]"}
{"concept_id": "C3268631", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin. [GOC:jl]"}
{"concept_id": "C3268632", "aliases": [], "types": ["T044"], "canonical_name": "aliphatic (S)-hydroxynitrile lyase activity", "definition": "Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide. [EC:4.1.2.47]"}
{"concept_id": "C3268633", "aliases": ["(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity"], "types": ["T044"], "canonical_name": "(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity"}
{"concept_id": "C3268634", "aliases": ["(S)-cyanohydrin producing hydroxynitrile lyase activity"], "types": ["T044"], "canonical_name": "(S)-cyanohydrin producing hydroxynitrile lyase activity"}
{"concept_id": "C3268635", "aliases": ["(S)-hydroxynitrile lyase activity"], "types": ["T044"], "canonical_name": "(S)-hydroxynitrile lyase activity"}
{"concept_id": "C3268636", "aliases": ["(S)-oxynitrilase activity"], "types": ["T044"], "canonical_name": "(S)-oxynitrilase activity"}
{"concept_id": "C3268637", "aliases": ["(S)-selective hydroxynitrile lyase activity"], "types": ["T044"], "canonical_name": "(S)-selective hydroxynitrile lyase activity"}
{"concept_id": "C3268638", "aliases": [], "types": ["T044"], "canonical_name": "aromatic (S)-hydroxynitrile lyase activity", "definition": "Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide. [EC:4.1.2.47, KEGG_REACTION:R09359]"}
{"concept_id": "C3268639", "aliases": [], "types": ["T044"], "canonical_name": "N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "definition": "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide. [MetaCyc:RXN-10465]"}
{"concept_id": "C3268640", "aliases": ["polyamine oxidase (propane-1,3-diamine-forming) activity"], "types": ["T044"], "canonical_name": "polyamine oxidase (propane-1,3-diamine-forming) activity"}
{"concept_id": "C3268642", "aliases": [], "types": ["T044"], "canonical_name": "norspermine oxidase activity"}
{"concept_id": "C3268643", "aliases": [], "types": ["T044"], "canonical_name": "N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity", "definition": "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide. [MetaCyc:POLYAMINE-OXIDASE-RXN]"}
{"concept_id": "C3268644", "aliases": [], "types": ["T044"], "canonical_name": "N1-acetylspermine oxidase activity"}
{"concept_id": "C3268645", "aliases": [], "types": ["T044"], "canonical_name": "spermidine oxidase (propane-1,3-diamine-forming) activity", "definition": "Catalysis of the reaction: H(2)O + O(2) + spermidine = 1,3-diaminopropane + 4-aminobutanal + H(2)O(2). [RHEA:25820]"}
{"concept_id": "C3268646", "aliases": [], "types": ["T044"], "canonical_name": "N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "definition": "Catalysis of the reaction: H(2)O + N(8)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2). [RHEA:25972]"}
{"concept_id": "C3268647", "aliases": [], "types": ["T044"], "canonical_name": "N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming) activity"}
{"concept_id": "C3268648", "aliases": [], "types": ["T044"], "canonical_name": "N1-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "definition": "Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2). [RHEA:25864]"}
{"concept_id": "C3268649", "aliases": [], "types": ["T044"], "canonical_name": "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "definition": "Catalysis of the reaction: H(2)O + N(1),N(12)-diacetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + N(1)-acetylspermidine. [RHEA:25868]"}
{"concept_id": "C3268650", "aliases": ["N(1)-acetylpolyamine oxidase activity"], "types": ["T044"], "canonical_name": "N(1)-acetylpolyamine oxidase activity"}
{"concept_id": "C3268651", "aliases": [], "types": ["T044"], "canonical_name": "spermine oxidase (propane-1,3-diamine-forming) activity", "definition": "Catalysis of the reaction: H(2)O + O(2) + spermine = 1,3-diaminopropane + H(2)O(2) + N-(3-aminopropyl)-4-aminobutanal. [RHEA:25824]"}
{"concept_id": "C3268652", "aliases": [], "types": ["T044"], "canonical_name": "spermine:oxygen oxidoreductase (spermidine-forming) activity", "definition": "Catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine. [RHEA:25804]"}
{"concept_id": "C3268653", "aliases": ["non-specific polyamine oxidase activity"], "types": ["T044"], "canonical_name": "non-specific polyamine oxidase activity"}
{"concept_id": "C3268654", "aliases": [], "types": ["T044"], "canonical_name": "spermine oxidase activity"}
{"concept_id": "C3268655", "aliases": [], "types": ["T044"], "canonical_name": "spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity", "definition": "Catalysis of the reaction: H(2)O + O(2) + spermidine = 3-aminopropanal + H(2)O(2) + putrescine. [RHEA:25808]"}
{"concept_id": "C3268656", "aliases": [], "types": ["T044"], "canonical_name": "N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "definition": "Catalysis of the reaction: H(2)O + N(1)-acetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + spermidine. [RHEA:25800]"}
{"concept_id": "C3268657", "aliases": [], "types": ["T044"], "canonical_name": "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "definition": "Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 3-acetamidopropanal + H(2)O(2) + putrescine. [RHEA:25812]"}
{"concept_id": "C3268658", "aliases": ["tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity", "tRNA (guanine-N(1)-)-methyltransferase activity", "tRNA m(1)G(9)-methyltransferase activity", "tRNA(m(1)G(9)/m(1)A(9))Mtase activity", "tRNA m(1)G(9) Mtase activity"], "types": ["T044"], "canonical_name": "tRNA (guanine(9)-N(1))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine. [EC:2.1.1.221]"}
{"concept_id": "C3268659", "aliases": ["tRNA-(N(1)G37) methyltransferase activity", "tRNA (m(1)G(37)) methyltransferase activity", "transfer RNA (m(1)G(37)) methyltransferase activity"], "types": ["T044"], "canonical_name": "tRNA (guanine(37)-N(1))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. [EC:2.1.1.228]"}
{"concept_id": "C3268660", "aliases": ["M(6)A(1618) activity"], "types": ["T045"], "canonical_name": "23S rRNA (adenine(1618)-N(6))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA. [EC:2.1.1.181]"}
{"concept_id": "C3268662", "aliases": [], "types": ["T045"], "canonical_name": "rRNA large subunit methyltransferase F activity"}
{"concept_id": "C3268663", "aliases": ["S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity"], "types": ["T044"], "canonical_name": "16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity", "definition": "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA. [RHEA:19609]"}
{"concept_id": "C3268664", "aliases": [], "types": ["T045"], "canonical_name": "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity", "definition": "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA. [RHEA:42780]"}
{"concept_id": "C3268665", "aliases": [], "types": ["T045"], "canonical_name": "M(6)(2)A dimethylase activity"}
{"concept_id": "C3268666", "aliases": [], "types": ["T045"], "canonical_name": "23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA. [EC:2.1.1.184]"}
{"concept_id": "C3268667", "aliases": [], "types": ["T045"], "canonical_name": "ermC 23S rRNA methyltransferase activity"}
{"concept_id": "C3268668", "aliases": [], "types": ["T045"], "canonical_name": "rRNA methyltransferase ermC' activity"}
{"concept_id": "C3268669", "aliases": [], "types": ["T045"], "canonical_name": "rRNA:m(6)A methyltransferase ermC' activity"}
{"concept_id": "C3268670", "aliases": ["23S rRNA m(1)G(745) methyltransferase activity"], "types": ["T045"], "canonical_name": "23S rRNA (guanine(745)-N(1))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine. [EC:2.1.1.187]"}
{"concept_id": "C3268671", "aliases": [], "types": ["T045"], "canonical_name": "ribosomal RNA(m(1)G)-methylase activity"}
{"concept_id": "C3268672", "aliases": [], "types": ["T045"], "canonical_name": "rlmA(I) methyltransferase activity"}
{"concept_id": "C3268673", "aliases": [], "types": ["T045"], "canonical_name": "rRNA(m(1)G)methylase activity"}
{"concept_id": "C3268674", "aliases": [], "types": ["T045"], "canonical_name": "23S rRNA (guanine(748)-N(1))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine. [EC:2.1.1.188]"}
{"concept_id": "C3268675", "aliases": [], "types": ["T045"], "canonical_name": "23S rRNA m(1)G(748) methyltransferase activity"}
{"concept_id": "C3268676", "aliases": [], "types": ["T045"], "canonical_name": "16S rRNA (guanine(966)-N(2))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine. [EC:2.1.1.171]"}
{"concept_id": "C3268677", "aliases": ["M(2)G1207 methyltransferase activity"], "types": ["T045"], "canonical_name": "16S rRNA (guanine(1207)-N(2))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine. [EC:2.1.1.172]"}
{"concept_id": "C3268678", "aliases": [], "types": ["T045"], "canonical_name": "23S rRNA (guanine(2445)-N(2))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine. [EC:2.1.1.173]"}
{"concept_id": "C3268679", "aliases": [], "types": ["T045"], "canonical_name": "23S rRNA (guanine(1835)-N(2))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine. [EC:2.1.1.174]"}
{"concept_id": "C3268680", "aliases": ["dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase", "dolichyl-P-mannose:Man(7)GlcNAc(2)-PP-dolichyl mannosyltransferase activity", "dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"], "types": ["T044"], "definition": "Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol. [PMID:10336995, RHEA:29535]", "canonical_name": "dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity"}
{"concept_id": "C3268681", "aliases": [], "types": ["T044"], "canonical_name": "dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "definition": "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. [EC:2.4.1.261, RHEA:29539]"}
{"concept_id": "C3268682", "aliases": [], "types": ["T044"], "canonical_name": "aliphatic (R)-hydroxynitrile lyase activity", "definition": "Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide. [EC:4.1.2.46]"}
{"concept_id": "C3268683", "aliases": ["(R)-hydroxynitrile lyase activity"], "types": ["T044"], "canonical_name": "(R)-HNL activity"}
{"concept_id": "C3268685", "aliases": [], "types": ["T044"], "canonical_name": "(2R)-2-hydroxy-2-methylbutanenitrile lyase activity", "definition": "Catalysis of the reaction: (2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide. [EC:4.1.2.46]"}
{"concept_id": "C3268686", "aliases": [], "types": ["T044"], "canonical_name": "acetone-cyanohydrin acetone-lyase (cyanide-forming) activity", "definition": "Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + acetone. [KEGG_REACTION:R01553, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN]"}
{"concept_id": "C3268687", "aliases": [], "types": ["T044"], "canonical_name": "hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "definition": "Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate. [RHEA:27555]"}
{"concept_id": "C3268688", "aliases": [], "types": ["T044"], "canonical_name": "(all-E) hexaprenyl diphosphate synthase activity"}
{"concept_id": "C3268689", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity", "definition": "Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate. [RHEA:27563]"}
{"concept_id": "C3268690", "aliases": ["nonaprenyl diphosphate synthase activity"], "types": ["T044"], "canonical_name": "nonaprenyl diphosphate synthase activity"}
{"concept_id": "C3268691", "aliases": ["solanesyl diphosphate synthetase activity"], "types": ["T044"], "canonical_name": "solanesyl diphosphate synthetase activity"}
{"concept_id": "C3268692", "aliases": [], "types": ["T044"], "canonical_name": "solPP synthase activity"}
{"concept_id": "C3268693", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "definition": "Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate. [RHEA:27594]"}
{"concept_id": "C3268694", "aliases": ["man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity", "dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity"], "types": ["T044"], "canonical_name": "dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity", "definition": "Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. [RHEA:29527]"}
{"concept_id": "C3268695", "aliases": [], "types": ["T044"], "canonical_name": "dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "definition": "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. [EC:2.4.1.259, RHEA:29531]"}
{"concept_id": "C3268696", "aliases": [], "types": ["T044"], "canonical_name": "dolichylphosphomannose-dependent ALG9 mannosyltransferase activity"}
{"concept_id": "C3268697", "aliases": ["CTP:tRNA cytidylyltransferase activity"], "types": ["T045"], "canonical_name": "CTP:tRNA cytidylyltransferase activity", "definition": "Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate. [KEGG_REACTION:R09383]"}
{"concept_id": "C3268698", "aliases": [], "types": ["T044"], "canonical_name": "CTP:3'-cytidine-tRNA cytidylyltransferase activity", "definition": "Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate. [KEGG_REACTION:R09384]"}
{"concept_id": "C3268699", "aliases": ["ATP:3'-CC-tRNA adenylyltransferase activity"], "types": ["T044"], "canonical_name": "ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity", "definition": "Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate. [RHEA:60012]"}
{"concept_id": "C3268708", "aliases": ["alcohol:cytochrome c(L) oxidoreductase activity"], "types": ["T044"], "canonical_name": "alcohol dehydrogenase (cytochrome c(L)) activity", "definition": "Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+. [RHEA:51004]"}
{"concept_id": "C3268709", "aliases": ["PQQ-dependent alcohol dehydrogenase activity", "alcohol:cytochrome c oxidoreductase activity"], "types": ["T044"], "canonical_name": "alcohol dehydrogenase (cytochrome c) activity", "definition": "Catalysis of the reaction: 2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H+. [RHEA:51020]"}
{"concept_id": "C3268711", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic process involved in mammary gland involution", "definition": "Any apoptotic process that triggers the activity of proteolytic caspases whose actions dismantle the mammary epithelial cells resulting in their programmed cell death. [GOC:dph, GOC:mtg_apoptosis]"}
{"concept_id": "C3268712", "aliases": [], "types": ["T043"], "canonical_name": "serotonin release, neurotransmission"}
{"concept_id": "C3268713", "aliases": ["clathrin sculpted glutamate transport vesicle", "clathrin sculpted glutamate constitutive secretory pathway transport vesicle"], "types": ["T026"], "canonical_name": "clathrin-sculpted glutamate transport vesicle", "definition": "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate. [GOC:dph]"}
{"concept_id": "C3268714", "aliases": ["clathrin sculpted acetylcholine transport vesicle", "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle"], "types": ["T026"], "canonical_name": "clathrin-sculpted acetylcholine transport vesicle", "definition": "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine. [GOC:dph]"}
{"concept_id": "C3268715", "aliases": ["clathrin sculpted acetylcholine transport vesicle membrane", "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle membrane"], "types": ["T026"], "canonical_name": "clathrin-sculpted acetylcholine transport vesicle membrane", "definition": "The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle. [GOC:dph]"}
{"concept_id": "C3268716", "aliases": ["clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle lumen", "clathrin sculpted acetylcholine transport vesicle lumen"], "types": ["T026"], "canonical_name": "clathrin-sculpted acetylcholine transport vesicle lumen", "definition": "The volume enclosed by the membrane of the clathrin-sculpted acetylcholine transport vesicle. [GOC:dph]"}
{"concept_id": "C3268717", "aliases": ["clathrin sculpted glutamate transport vesicle membrane", "clathrin sculpted glutamate constitutive secretory pathway transport vesicle membrane"], "types": ["T026"], "canonical_name": "clathrin-sculpted glutamate transport vesicle membrane", "definition": "The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle. [GOC:dph]"}
{"concept_id": "C3268718", "aliases": ["clathrin sculpted glutamate transport vesicle lumen", "clathrin sculpted glutamate constitutive secretory pathway transport vesicle lumen"], "types": ["T026"], "canonical_name": "clathrin-sculpted glutamate transport vesicle lumen", "definition": "The volume enclosed by the membrane of the clathrin-sculpted glutamate transport vesicle. [GOC:dph]"}
{"concept_id": "C3268720", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic process involved in morphogenesis", "definition": "Any apoptotic process that contributes to the shaping of an anatomical structure. [GOC:dph, GOC:mtg_apoptosis]"}
{"concept_id": "C3268721", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in morphogenesis"}
{"concept_id": "C3268723", "aliases": [], "types": ["T044"], "canonical_name": "L-cystathionine cysteine-lyase (deaminating)"}
{"concept_id": "C3268725", "aliases": ["metacaspase activity"], "types": ["T044"], "canonical_name": "metacaspase activity"}
{"concept_id": "C3268726", "aliases": [], "types": ["T044"], "canonical_name": "inositol-hexakisphosphate phosphatase activity", "definition": "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate. [EC:3.1.3.62]"}
{"concept_id": "C3268731", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in luteolysis"}
{"concept_id": "C3268732", "aliases": [], "types": ["T043"], "canonical_name": "regulation of extent of cell growth", "definition": "Any process that modulates the extent of cell growth. [GOC:mah, GOC:vw]"}
{"concept_id": "C3268733", "aliases": [], "types": ["T043"], "canonical_name": "regulation of rate of cell growth", "definition": "Any process that modulates the rate of cell growth. [GOC:mah, GOC:vw]"}
{"concept_id": "C3268734", "aliases": [], "types": ["T043"], "canonical_name": "regulation of direction of cell growth", "definition": "Any process that modulates the direction of cell growth. [GOC:mah, GOC:vw]"}
{"concept_id": "C3268735", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of direction of cell growth", "definition": "Any process that increases the direction of cell growth. [GOC:mah, GOC:vw]"}
{"concept_id": "C3268736", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of direction of cell growth", "definition": "Any process that decreases the direction of cell growth. [GOC:mah, GOC:vw]"}
{"concept_id": "C3268739", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance", "definition": "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. [GOC:dph]"}
{"concept_id": "C3268740", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. [GOC:dph]"}
{"concept_id": "C3268744", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus. [GOC:dph]"}
{"concept_id": "C3268745", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to calcium ion", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus. [GOC:dph]"}
{"concept_id": "C3268747", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to acidity"}
{"concept_id": "C3268748", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. [GOC:dph]"}
{"concept_id": "C3268750", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. [GOC:dph]"}
{"concept_id": "C3268751", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose. [GOC:dph]"}
{"concept_id": "C3268752", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus. [GOC:dph]"}
{"concept_id": "C3268753", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to heat stress", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:dph]"}
{"concept_id": "C3268754", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to freezing", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius. [GOC:dph]"}
{"concept_id": "C3268755", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to ethanol", "definition": "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus. [GOC:dph]"}
{"concept_id": "C3268756", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to cold", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:dph]"}
{"concept_id": "C3268757", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids. [GOC:dph]"}
{"concept_id": "C3268758", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source", "definition": "A transcription regulation process in which the presence of a nonfermentable carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. [GOC:dph, PMID:19686338]"}
{"concept_id": "C3268759", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source", "definition": "A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. [GOC:dph, PMID:19686338]"}
{"concept_id": "C3268760", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source", "definition": "A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. [GOC:dph, PMID:19686338]"}
{"concept_id": "C3268762", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress", "definition": "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:dph, PMID:9767597]"}
{"concept_id": "C3268763", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter in response to hypoxia", "definition": "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. [GOC:dph, PMID:12511571]"}
{"concept_id": "C3268764", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to hypoxia", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. [GOC:dph]"}
{"concept_id": "C3268765", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter in response to biotin starvation", "definition": "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of biotin. [GOC:dph, PMID:16533810]"}
{"concept_id": "C3268766", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription by oleic acid", "definition": "Any process involving oleic acid that activates or increases the rate of transcription. [GOC:dph, PMID:20395639]"}
{"concept_id": "C3268767", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to alkalinity"}
{"concept_id": "C3268768", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter", "definition": "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter resulting in the increased frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, PMID:11523797]"}
{"concept_id": "C3268770", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter", "definition": "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process. [GOC:dph, PMID:10608811, PMID:7760841]"}
{"concept_id": "C3268771", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter", "definition": "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of sulfite transport. [GOC:dph, PMID:10234785, PMID:10870099]"}
{"concept_id": "C3268773", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter in response to hypoxia", "definition": "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. [GOC:dph, PMID:17785431]"}
{"concept_id": "C3268774", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter by oleic acid", "definition": "Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:dph, PMID:20395639]"}
{"concept_id": "C3268775", "aliases": [], "types": ["T042"], "canonical_name": "bone trabecula morphogenesis", "definition": "The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:BHF, GOC:dph, GOC:vk]"}
{"concept_id": "C3268776", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to methionine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus. [GOC:dph, PMID:7891681]"}
{"concept_id": "C3268778", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to caloric restriction", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake. [GOC:dph, PMID:17914901]"}
{"concept_id": "C3268780", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from a mobile element promoter", "definition": "Any process that activates or increases the frequency, rate or extent of transcription from a mobile element promoter. [GOC:dph, PMID:12230120, PMID:9271107]"}
{"concept_id": "C3268781", "aliases": ["skin barrier development"], "types": ["T040"], "canonical_name": "establishment of skin barrier", "definition": "Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability. [GOC:dph]"}
{"concept_id": "C3268782", "aliases": ["establishment of epithelial barrier"], "types": ["T040"], "canonical_name": "epithelial barrier development"}
{"concept_id": "C3268783", "aliases": [], "types": ["T042"], "canonical_name": "renal system vasculature development", "definition": "The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]"}
{"concept_id": "C3268784", "aliases": [], "types": ["T042"], "canonical_name": "renal system vasculature morphogenesis", "definition": "The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form. [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]"}
{"concept_id": "C3268785", "aliases": [], "types": ["T042"], "canonical_name": "kidney vasculature morphogenesis", "definition": "The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form. [GOC:dph, GOC:mtg_kidney_jan10]"}
{"concept_id": "C3268786", "aliases": [], "types": ["T042"], "canonical_name": "kidney vasculature development", "definition": "The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure. [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]"}
{"concept_id": "C3268787", "aliases": [], "types": ["T042"], "canonical_name": "renal artery morphogenesis", "definition": "The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood. [GOC:mtg_kidney_jan10, PMID:11891195]"}
{"concept_id": "C3268788", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscle cell fate determination", "definition": "The process involved in cardiac muscle cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3268789", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cushion cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3268790", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cushion cell development", "definition": "The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3268791", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cushion cell fate commitment", "definition": "The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3268792", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cushion cell fate determination", "definition": "The process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3268793", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cushion cell fate specification", "definition": "The process involved in the specification of endocardial cushion cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3268794", "aliases": ["clathrin sculpted monoamine transport vesicle", "clathrin sculpted monoamine constitutive secretory pathway transport vesicle"], "types": ["T026"], "canonical_name": "clathrin-sculpted monoamine transport vesicle", "definition": "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines. [GOC:mg2]"}
{"concept_id": "C3268795", "aliases": ["clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen", "clathrin sculpted monoamine transport vesicle lumen"], "types": ["T026"], "canonical_name": "clathrin-sculpted monoamine transport vesicle lumen", "definition": "The volume enclosed by the membrane of the clathrin-sculpted monoamine transport vesicle. [GOC:mg2]"}
{"concept_id": "C3268796", "aliases": ["clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane", "clathrin sculpted monoamine transport vesicle membrane"], "types": ["T026"], "canonical_name": "clathrin-sculpted monoamine transport vesicle membrane", "definition": "The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle. [GOC:mg2]"}
{"concept_id": "C3268798", "aliases": ["attachment of telomeric chromatin to nuclear envelope"], "types": ["T043"], "canonical_name": "attachment of telomeric chromatin to nuclear envelope"}
{"concept_id": "C3268799", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of lymphocyte apoptosis"}
{"concept_id": "C3268800", "aliases": ["upregulation of lymphocyte apoptosis", "positive regulation of lymphocyte apoptosis", "up-regulation of lymphocyte apoptosis", "up regulation of lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of lymphocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C3268801", "aliases": ["down regulation of thymocyte apoptosis", "downregulation of thymocyte apoptosis", "negative regulation of thymocyte apoptosis", "down-regulation of thymocyte apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of thymocyte apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]"}
{"concept_id": "C3268810", "aliases": [], "types": ["T043"], "canonical_name": "transmembrane calcium influx"}
{"concept_id": "C3268812", "aliases": ["L-threonine breakdown to propionate", "L-threonine degradation to propionate", "L-threonine catabolism to propionate"], "types": ["T044"], "canonical_name": "L-threonine catabolic process to propionate", "definition": "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate. [GOC:bf, GOC:mah, MetaCyc:PWY-5437]"}
{"concept_id": "C3268813", "aliases": ["L-threonine degradation to acetyl-CoA", "L-threonine catabolism to acetyl-CoA", "L-threonine breakdown to acetyl-CoA"], "types": ["T044"], "canonical_name": "L-threonine catabolic process to acetyl-CoA", "definition": "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA. [GOC:bf, GOC:mah, MetaCyc:PWY-5436]"}
{"concept_id": "C3268814", "aliases": [], "types": ["T044"], "canonical_name": "termination of calcineurin-NFAT signaling cascade"}
{"concept_id": "C3268816", "aliases": ["MAPKKK cascade involved in conjugation with cellular fusion", "conjugation with cellular fusion, MAPKKK cascade", "MAPK cascade involved in conjugation with cellular fusion", "MAPKKK cascade involved in mating response"], "types": ["T044"], "canonical_name": "pheromone response MAPK cascade", "definition": "A MAPK cascade that is part of a pheromone response ending in conjugation with cellular fusion. [GOC:mah, GOC:vw, PMID:17604854]"}
{"concept_id": "C3268817", "aliases": [], "types": ["T044"], "canonical_name": "Fus3 signaling cascade"}
{"concept_id": "C3268818", "aliases": [], "types": ["T044"], "canonical_name": "MAPK signaling in response to pheromone"}
{"concept_id": "C3268819", "aliases": [], "types": ["T044"], "canonical_name": "pheromone MAPK module"}
{"concept_id": "C3268820", "aliases": ["neuronal RNP granule"], "types": ["T026"], "definition": "A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli. [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989]", "canonical_name": "neuronal ribonucleoprotein granule"}
{"concept_id": "C3268822", "aliases": [], "types": ["T044"], "canonical_name": "High Osmolarity Glycerol (HOG) MAPK pathway"}
{"concept_id": "C3268823", "aliases": [], "types": ["T044"], "canonical_name": "Hog1 MAPK pathway"}
{"concept_id": "C3268824", "aliases": [], "types": ["T044"], "canonical_name": "ERK/MAPK cascade"}
{"concept_id": "C3268826", "aliases": [], "types": ["T044"], "canonical_name": "Mpk1 cascade"}
{"concept_id": "C3268827", "aliases": [], "types": ["T044"], "canonical_name": "Slt2 cascade"}
{"concept_id": "C3268829", "aliases": [], "types": ["T044"], "canonical_name": "ligand-dependent transcription factor activity"}
{"concept_id": "C3268830", "aliases": ["RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding", "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity"], "types": ["T044"], "canonical_name": "nuclear receptor activity", "definition": "A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. [GOC:txnOH-2018]"}
{"concept_id": "C3268832", "aliases": ["transmembrane signalling receptor activity"], "types": ["T044"], "canonical_name": "transmembrane signaling receptor activity", "definition": "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor]"}
{"concept_id": "C3268833", "aliases": ["G-protein coupled GABA receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled GABA receptor activity", "definition": "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]"}
{"concept_id": "C3268834", "aliases": [], "types": ["T044"], "canonical_name": "metabotropic GABA receptor"}
{"concept_id": "C3268835", "aliases": ["repulsive netrin receptor activity", "netrin receptor activity involved in negative chemotaxis"], "types": ["T044"], "canonical_name": "netrin receptor activity involved in chemorepulsion", "definition": "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin. [GOC:dph, GOC:signaling]"}
{"concept_id": "C3268836", "aliases": ["macrophage receptor activity"], "types": ["T044"], "canonical_name": "macrophage receptor activity", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C3268841", "aliases": [], "types": ["T030"], "canonical_name": "nephrocyte diaphragm", "definition": "A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates. [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]"}
{"concept_id": "C3268844", "aliases": ["1,3-beta-D-glucan metabolism", "beta-1,3 glucan metabolic process", "1,3-beta-D-glucan metabolic process", "beta-1,3 glucan metabolism", "1,3-beta-glucan metabolic process"], "types": ["T044"], "canonical_name": "(1->3)-beta-D-glucan metabolic process", "definition": "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds. [ISBN:0198506732]"}
{"concept_id": "C3268846", "aliases": ["nucleobase, nucleoside and nucleotide metabolic process"], "types": ["T044"], "canonical_name": "nucleobase, nucleoside and nucleotide metabolic process"}
{"concept_id": "C3268848", "aliases": [], "types": ["T044"], "canonical_name": "polyunsaturated fatty acid biosynthesis"}
{"concept_id": "C3268849", "aliases": [], "types": ["T044"], "canonical_name": "porphyrin-containing compound metabolic process", "definition": "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]"}
{"concept_id": "C3268850", "aliases": [], "types": ["T044"], "canonical_name": "porphyrin-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]"}
{"concept_id": "C3268854", "aliases": [], "types": ["T044"], "canonical_name": "porphyrin-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C3268855", "aliases": ["cellular suicide"], "types": ["T043"], "canonical_name": "cell suicide"}
{"concept_id": "C3268856", "aliases": ["activation of metacaspase activity"], "types": ["T044"], "canonical_name": "activation of metacaspase activity"}
{"concept_id": "C3268857", "aliases": ["cellular component disassembly involved in apoptosis"], "types": ["T043"], "canonical_name": "cellular component disassembly involved in apoptotic process"}
{"concept_id": "C3268860", "aliases": ["negative regulation of detachment induced cell death", "negative regulation of suspension induced apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of anoikis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. [GOC:obol]"}
{"concept_id": "C3268861", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of cell polarity regulating cell shape", "definition": "Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell. [GOC:mah]"}
{"concept_id": "C3268862", "aliases": [], "types": ["T043"], "canonical_name": "establishment of cell polarity regulating cell shape", "definition": "Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell. [GOC:mah]"}
{"concept_id": "C3268864", "aliases": [], "types": ["T026"], "definition": "A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]", "canonical_name": "meiotic spindle"}
{"concept_id": "C3268865", "aliases": ["establishment and maintenance of SHREC complex localization", "SHREC complex localisation"], "types": ["T043"], "canonical_name": "SHREC complex localization", "definition": "Any process in which a SHREC complex is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C3268866", "aliases": [], "types": ["T044"], "canonical_name": "MCM complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an MCM complex, a hexameric protein complex required for the initiation and regulation of DNA replication. [GOC:mah, PMID:21813639]"}
{"concept_id": "C3268867", "aliases": ["vegetative growth of a single-celled organism"], "types": ["T043"], "canonical_name": "single-celled organism vegetative growth phase", "definition": "A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods. [GOC:mah, GOV:vw]"}
{"concept_id": "C3268871", "aliases": ["DNA replication initiation involved in meiotic DNA replication", "DNA replication initiation involved in meiotic cell cycle DNA replication"], "types": ["T045"], "canonical_name": "meiotic DNA replication initiation", "definition": "Any DNA replication initiation involved in meiotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie, PMID:10888871]"}
{"concept_id": "C3268876", "aliases": ["regulation of telomeric recombination"], "types": ["T045"], "canonical_name": "regulation of DNA recombination at telomere", "definition": "Any process that modulates the frequency, rate or extent of DNA recombination within the telomere. [GOC:mah]"}
{"concept_id": "C3268877", "aliases": ["up-regulation of telomeric recombination at telomere", "positive regulation of telomeric recombination", "upregulation of telomeric recombination at telomere", "up regulation of telomeric recombination at telomere"], "types": ["T043"], "canonical_name": "positive regulation of DNA recombination at telomere", "definition": "Any process that activates or increases the frequency, rate or extent of DNA recombination within the telomere. [GOC:mah]"}
{"concept_id": "C3268878", "aliases": [], "types": ["T043"], "canonical_name": "activation of telomeric recombination at telomere"}
{"concept_id": "C3268879", "aliases": ["endocytosis involved in viral entry into host cell", "viral penetration via endocytosis followed by endosome disruption", "virus endocytosis by host"], "types": ["T043"], "definition": "Any endocytosis that is involved in the uptake of a virus into a host cell. [GOC:bf, GOC:jl, VZ:977]", "canonical_name": "viral entry into host cell via endocytosis"}
{"concept_id": "C3268880", "aliases": ["viral entry into host cell via macropinocytosis"], "types": ["T043"], "canonical_name": "macropinocytosis involved in viral entry into host cell", "definition": "Any macropinocytosis that is involved in the uptake of a virus into a host cell. [GOC:jl, GOC:sp, PMID:17077125, PMID:19404330, VZ:800]"}
{"concept_id": "C3268881", "aliases": [], "types": ["T043"], "canonical_name": "macropinosome lysis involved in viral entry into host cell", "definition": "Viral-induced lysis of the macropinosome involved in the uptake of a virus into a host cell. Occurs after internalization of the virus in a macropinosome, and results in the release of viral contents from the macropinosome into the host cell cytoplasm. [GOC:bf, GOC:jl]"}
{"concept_id": "C3268882", "aliases": ["viral entry into host cell via clathrin-mediated endocytosis", "viral penetration via clathrin-mediated endocytosis", "clathrin-mediated endocytosis of virus by host cell"], "types": ["T043"], "canonical_name": "clathrin-dependent endocytosis of virus by host cell", "definition": "Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus. [GOC:bf, GOC:jl, VZ:957]"}
{"concept_id": "C3268883", "aliases": ["caveolin-mediated endocytosis of virus by host cell", "viral entry into host cell via caveolae-mediated endocytosis"], "types": ["T043"], "definition": "Any caveolin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins when material is taken up into plasma membrane caveolae - specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane - which then pinch off to form endocytic caveolar carriers containing the virus. [GOC:bf, GOC:jl, VZ:976]", "canonical_name": "viral penetration via caveolae-mediated endocytosis followed by endosome disruption"}
{"concept_id": "C3268884", "aliases": ["viral entry into host cell via caveolae-mediated endocytosis followed by endosome lysis"], "types": ["T043"], "canonical_name": "endosome lysis involved in viral entry into host cell", "definition": "Viral-induced lysis of the endosome involved in uptake of a virus into a host cell. Occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents from the endosome into the host cell cytoplasm. [GOC:bf, GOC:jl]"}
{"concept_id": "C3268886", "aliases": [], "types": ["T043"], "canonical_name": "viral entry into host cell via clathrin-mediated endocytosis followed by endosome lysis"}
{"concept_id": "C3268887", "aliases": ["viral penetration via endocytosis followed by clathrin-mediated membrane fusion with the endosome membrane"], "types": ["T043"], "canonical_name": "viral entry into host cell via clathrin-mediated endocytosis followed by membrane fusion with the endosome membrane"}
{"concept_id": "C3268888", "aliases": [], "types": ["T043"], "canonical_name": "viral entry into host cell via clathrin-mediated endocytosis followed by endosome membrane permeabilization"}
{"concept_id": "C3268889", "aliases": [], "types": ["T040"], "canonical_name": "lateral root branching", "definition": "Any process involved in the formation of branches in lateral roots. [GOC:tb]"}
{"concept_id": "C3268890", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K4 trimethylation", "definition": "The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. [GOC:BHF, GOC:se, GOC:tb]"}
{"concept_id": "C3268891", "aliases": [], "types": ["T043"], "canonical_name": "response to photooxidative stress", "definition": "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. [DOI:10.1111/j.1399-3054.1994.tb03042.x]"}
{"concept_id": "C3268892", "aliases": [], "types": ["T043"], "canonical_name": "response to phenylpropanoid", "definition": "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin. [GOC:tb]"}
{"concept_id": "C3268893", "aliases": ["induction by organism of host gene-for-gene resistance", "activation by organism of host resistance gene-dependent defense response", "positive regulation by organism of host gene-for-gene resistance", "activation by organism of host gene-for-gene resistance", "positive regulation by symbiont of plant hypersensitive response", "positive regulation by symbiont of plant HR", "induction by symbiont of host resistance gene-dependent defense response", "activation by symbiont of host resistance gene-dependent defense response"], "types": ["T040"], "canonical_name": "effector-mediated induction of plant hypersensitive response by symbiont", "definition": "A symbiont process in which a molecule secreted by the symbiont activates a resistance gene-dependent defense response signaling pathway in the plant host, in order to activate a hypersensitive response to induce necrosis. In the plant, this process involves the direct or indirect recognition of the symbiont effector protein for example through plant resistance receptor or R proteins (or R genes). [PMID:16497589, PMID:22241993, PMID:23411798, PMID:27641772]"}
{"concept_id": "C3268894", "aliases": [], "types": ["T040"], "canonical_name": "developmental vegetative growth", "definition": "The increase in size or mass of non-reproductive plant parts. [PO:0007134]"}
{"concept_id": "C3268895", "aliases": [], "types": ["T040"], "canonical_name": "floral organ senescence", "definition": "The last stage of flower development during which programmed degradation of macromolecules and nutrient recycling take place. [PMID:19380421, PMID:21689171]"}
{"concept_id": "C3268896", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscle cell action potential", "definition": "An action potential that occurs in a cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268897", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscle cell action potential involved in contraction", "definition": "An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268898", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscle cell contraction", "definition": "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268899", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardiac muscle cell contraction", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268900", "aliases": [], "types": ["T043"], "canonical_name": "ventricular cardiac muscle cell action potential", "definition": "An action potential that occurs in a ventricular cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268901", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated sodium channel activity involved in cardiac muscle cell action potential", "definition": "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268902", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved in cardiac muscle cell action potential", "definition": "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268903", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization", "definition": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268904", "aliases": [], "types": ["T043"], "canonical_name": "membrane repolarization", "definition": "The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268905", "aliases": [], "types": ["T043"], "canonical_name": "membrane repolarization during action potential", "definition": "The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268906", "aliases": [], "types": ["T043"], "canonical_name": "membrane depolarization during cardiac muscle cell action potential", "definition": "The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268907", "aliases": [], "types": ["T043"], "canonical_name": "membrane repolarization during cardiac muscle cell action potential", "definition": "The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268908", "aliases": [], "types": ["T043"], "canonical_name": "atrial cardiac muscle cell action potential", "definition": "An action potential that occurs in an atrial cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268909", "aliases": ["sinoatrial node cardiac muscle cell action potential", "SA node cardiac muscle cell action potential", "SAN cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "SA node cell action potential", "definition": "An action potential that occurs in a sinoatrial node cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268910", "aliases": ["atrioventricular node cardiac muscle cell action potential", "AV node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "AV node cell action potential", "definition": "An action potential that occurs in an atrioventricular node cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268911", "aliases": [], "types": ["T043"], "canonical_name": "Purkinje myocyte action potential", "definition": "An action potential that occurs in a Purkinje myocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268912", "aliases": ["SA node cardiomyocyte to atrial cardiomyocyte signalling", "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling", "SAN cardiomyocyte to atrial cardiomyocyte signalling", "SA node cardiac muscle cell to atrial cardiac muscle cell signalling"], "types": ["T043"], "canonical_name": "SA node cell to atrial cardiac muscle cell signaling", "definition": "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268913", "aliases": ["cell-cell signalling involved in cardiac conduction"], "types": ["T043"], "canonical_name": "cell-cell signaling involved in cardiac conduction", "definition": "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268914", "aliases": ["gap junction channel activity involved in sinoatrial node cell-atrial cardiomyocyte electrical coupling", "gap junction channel activity involved in sinus node cell-atrial cardiomyocyte electrical coupling", "gap junction channel activity involved in SAN cell-atrial cardiomyocyte electrical coupling", "gap junction channel activity involved in SA node cell-atrial cardiomyocyte electrical coupling"], "types": ["T044"], "canonical_name": "gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling", "definition": "A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268915", "aliases": ["SA node cardiac muscle cell to atrial cardiac muscle cell communication by electrical coupling", "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling", "SA node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling", "SAN cardiomyocyte to atrial cardiomyocyte communication by electrical coupling"], "types": ["T043"], "canonical_name": "SA node cell to atrial cardiac muscle cell communication by electrical coupling", "definition": "The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268916", "aliases": ["SA cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication", "SAN cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication", "SA cardiac muscle cell-atrial cardiac muscle cell adhesion involved in cell communication", "sinoatrial node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication"], "types": ["T043"], "canonical_name": "SA node cell-atrial cardiac muscle cell adhesion involved in cell communication", "definition": "The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268917", "aliases": ["atrial cardiomyocyte to AV node cell signalling", "atrial cardiomyocyte to atrioventricular node cell signaling", "atrial cardiomyocyte to AV node cell signaling"], "types": ["T043"], "canonical_name": "atrial cardiac muscle cell to AV node cell signaling", "definition": "Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268919", "aliases": ["bundle of His cardiac muscle cell to Purkinje myocyte signalling", "bundle of His cardiac muscle cell to Purkinje myocyte signaling"], "types": ["T043"], "canonical_name": "bundle of His cell to Purkinje myocyte signaling", "definition": "Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268920", "aliases": ["Purkinje myocyte to ventricular cardiac muscle cell signalling"], "types": ["T043"], "canonical_name": "Purkinje myocyte to ventricular cardiac muscle cell signaling", "definition": "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268921", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardiac muscle cell membrane potential", "definition": "Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268922", "aliases": [], "types": ["T044"], "canonical_name": "P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268923", "aliases": [], "types": ["T044"], "canonical_name": "calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268924", "aliases": ["calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential"], "types": ["T044"], "canonical_name": "P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential", "definition": "A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268925", "aliases": ["sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential"], "types": ["T044"], "canonical_name": "sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential", "definition": "Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268926", "aliases": ["voltage-gated potassium channel activity involved in SAN cell action potential depolarization", "voltage-gated potassium channel activity involved in sinus node cell action potential depolarization", "voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization"], "types": ["T044"], "canonical_name": "voltage-gated potassium channel activity involved in SA node cell action potential depolarization", "definition": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268927", "aliases": ["cardiomyocyte-cardiomyocyte adhesion"], "types": ["T043"], "canonical_name": "cardiac muscle cell-cardiac muscle cell adhesion", "definition": "The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268928", "aliases": ["bundle of His cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "bundle of His cell action potential", "definition": "An action potential that occurs in a bundle of His cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268929", "aliases": ["atrial cardiomyocyte to AV node cell communication by electrical coupling", "atrial cardiomyocyte to atrioventricular node cell communication by electrical coupling"], "types": ["T043"], "canonical_name": "atrial cardiac muscle cell to AV node cell communication by electrical coupling", "definition": "The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268930", "aliases": ["membrane depolarization during atrioventricular node cardiac muscle cell action potential", "membrane depolarization during AV node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "membrane depolarization during AV node cell action potential", "definition": "The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268931", "aliases": ["membrane depolarization involved in regulation of SAN cardiac muscle cell action potential", "membrane depolarization involved in regulation of SA node cardiac muscle cell action potential", "membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "membrane depolarization during SA node cell action potential", "definition": "The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268932", "aliases": [], "types": ["T043"], "canonical_name": "membrane depolarization during Purkinje myocyte cell action potential", "definition": "The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268933", "aliases": ["membrane depolarization during bundle of His cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "membrane depolarization during bundle of His cell action potential", "definition": "The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268934", "aliases": ["membrane repolarization involved in regulation of atrioventricular node cardiac muscle cell action potential", "membrane repolarization involved in regulation of AV node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "membrane repolarization during AV node cell action potential", "definition": "The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268935", "aliases": ["membrane repolarization during bundle of His cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "membrane repolarization during bundle of His cell action potential", "definition": "The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268936", "aliases": [], "types": ["T043"], "canonical_name": "membrane repolarization during Purkinje myocyte action potential", "definition": "The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268937", "aliases": ["membrane repolarization involved in regulation of sinus node cardiac muscle cell action potential", "membrane repolarization involved in regulation of sinoatrial node cardiac muscle cell action potential", "membrane repolarization involved in regulation of SAN cardiac muscle cell action potential", "membrane repolarization involved in regulation of SA node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "membrane repolarization during SA node cell action potential", "definition": "The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268938", "aliases": ["atrioventricular node cell to bundle of His cell communication by electrical coupling"], "types": ["T043"], "canonical_name": "AV node cell to bundle of His cell communication by electrical coupling", "definition": "The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268939", "aliases": ["bundle of His cardiac muscle cell to Purkinje myocyte communication by electrical coupling"], "types": ["T043"], "canonical_name": "bundle of His cell to Purkinje myocyte communication by electrical coupling", "definition": "The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268940", "aliases": [], "types": ["T043"], "canonical_name": "Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling", "definition": "The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268941", "aliases": ["voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential", "voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential"], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved in AV node cell action potential", "definition": "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268942", "aliases": ["voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential"], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved in bundle of His cell action potential", "definition": "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268943", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential", "definition": "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268944", "aliases": ["voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential", "voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential", "voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential"], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved SA node cell action potential", "definition": "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268945", "aliases": ["voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential", "voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential"], "types": ["T044"], "canonical_name": "voltage-gated sodium channel activity involved in AV node cell action potential", "definition": "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268946", "aliases": ["voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential"], "types": ["T044"], "canonical_name": "voltage-gated sodium channel activity involved in bundle of His cell action potential", "definition": "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268947", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated sodium channel activity involved in Purkinje myocyte action potential", "definition": "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268948", "aliases": ["voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential", "voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential", "voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential"], "types": ["T044"], "canonical_name": "voltage-gated sodium channel activity involved in SA node cell action potential", "definition": "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268949", "aliases": [], "types": ["T043"], "canonical_name": "cell communication by electrical coupling involved in cardiac conduction", "definition": "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268950", "aliases": [], "types": ["T043"], "canonical_name": "cell communication involved in cardiac conduction", "definition": "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268951", "aliases": ["atrial cardiomyocyte to AV node cell communication", "atrial cardiomyocyte to atrioventricular node cell communication"], "types": ["T043"], "canonical_name": "atrial cardiac muscle cell to AV node cell communication", "definition": "The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268952", "aliases": ["atrioventricular node cell to bundle of His cell communication"], "types": ["T043"], "canonical_name": "AV node cell to bundle of His cell communication", "definition": "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268953", "aliases": [], "types": ["T043"], "canonical_name": "Purkinje myocyte to ventricular cardiac muscle cell communication", "definition": "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268954", "aliases": ["bundle of His cardiac muscle cell to Purkinje myocyte communication", "ventricular conduction system cell to cell communication"], "types": ["T043"], "canonical_name": "bundle of His cell to Purkinje myocyte communication", "definition": "The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268955", "aliases": ["SA node cardiac muscle cell to atrial cardiac muscle cell communication", "SAN cardiomyocyte to atrial cardiomyocyte communication", "SA node cardiomyocyte to atrial cardiomyocyte communication", "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication"], "types": ["T043"], "canonical_name": "SA node cell to atrial cardiac muscle cell communication", "definition": "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268956", "aliases": ["atrial cardiomyocyte-AV node cell adhesion involved in cell communication", "atrial cardiomyocyte-atrioventricular node cell adhesion involved in cell communication"], "types": ["T043"], "canonical_name": "atrial cardiac muscle cell-AV node cell adhesion involved in cell communication", "definition": "The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268957", "aliases": ["atrioventricular node cell-bundle of His cell adhesion involved in cell communication"], "types": ["T043"], "canonical_name": "AV node cell-bundle of His cell adhesion involved in cell communication", "definition": "The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268958", "aliases": [], "types": ["T043"], "canonical_name": "bundle of His cell-Purkinje myocyte adhesion involved in cell communication", "definition": "The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268959", "aliases": [], "types": ["T043"], "canonical_name": "Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication", "definition": "The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268960", "aliases": [], "types": ["T044"], "canonical_name": "gap junction channel activity involved in cardiac conduction electrical coupling", "definition": "A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268961", "aliases": [], "types": ["T044"], "canonical_name": "gap junction channel activity involved in atrial cardiomyocyte-AV node cell electrical coupling"}
{"concept_id": "C3268962", "aliases": ["gap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling"], "types": ["T044"], "canonical_name": "gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling", "definition": "A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268963", "aliases": [], "types": ["T044"], "canonical_name": "gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling", "definition": "A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268964", "aliases": [], "types": ["T044"], "canonical_name": "gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling", "definition": "A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268965", "aliases": [], "types": ["T044"], "canonical_name": "protein binding involved in heterotypic cell-cell adhesion", "definition": "Binding to a protein or protein complex contributing to the adhesion of two different types of cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268966", "aliases": ["cell adhesive protein binding involved in atrial cardiomyocyte-atrioventricular node cell communication", "cell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication"], "types": ["T044"], "canonical_name": "cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication", "definition": "Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268967", "aliases": ["cell adhesive protein binding involved in atrioventricular node cell-bundle of His cell communication"], "types": ["T044"], "canonical_name": "cell adhesive protein binding involved in AV node cell-bundle of His cell communication", "definition": "Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268968", "aliases": [], "types": ["T044"], "canonical_name": "cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication", "definition": "Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268969", "aliases": [], "types": ["T044"], "canonical_name": "cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication", "definition": "Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268970", "aliases": ["cell adhesive protein binding involved in SA cardiomyocyte-atrial cardiomyocyte communication"], "types": ["T044"], "canonical_name": "cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication", "definition": "Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268971", "aliases": ["voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential", "voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization"], "types": ["T044"], "canonical_name": "voltage-gated potassium channel activity involved in AV node cell action potential repolarization", "definition": "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268972", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization", "definition": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268973", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization", "definition": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268974", "aliases": ["voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization"], "types": ["T044"], "canonical_name": "voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "definition": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268975", "aliases": ["voltage-gated potassium channel activity involved in sinoatrial node cell action potential", "voltage-gated potassium channel activity involved in sinus node cell action potential", "voltage-gated potassium channel activity involved in SAN cell action potential"], "types": ["T044"], "canonical_name": "voltage-gated potassium channel activity involved in SA node cell action potential repolarization", "definition": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268976", "aliases": [], "types": ["T039"], "canonical_name": "regulation of heart rate by cardiac conduction", "definition": "A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268977", "aliases": [], "types": ["T039"], "canonical_name": "regulation of the force of heart contraction by cardiac conduction", "definition": "A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3268979", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transmembrane calcium influx"}
{"concept_id": "C3268980", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of transmembrane calcium influx"}
{"concept_id": "C3268981", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mitochondrial DNA synthesis"}
{"concept_id": "C3268982", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mitochondrial DNA synthesis"}
{"concept_id": "C3268983", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial DNA synthesis"}
{"concept_id": "C3268984", "aliases": ["regulation of cell wall 1,3-beta-D-glucan biosynthetic process"], "types": ["T043"], "canonical_name": "regulation of cell wall (1->3)-beta-D-glucan biosynthetic process", "definition": "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells. [GOC:tb]"}
{"concept_id": "C3268985", "aliases": [], "types": ["T044"], "canonical_name": "malonyl-CoA synthetase activity", "definition": "Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate. [MetaCyc:RXN-12359]"}
{"concept_id": "C3268986", "aliases": [], "types": ["T044"], "canonical_name": "malonate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of malonate, the propanedioate ion. [GOC:tb]"}
{"concept_id": "C3268987", "aliases": [], "types": ["T044"], "canonical_name": "brassinosteroid binding", "definition": "Binding to a brassinosteroid. [GOC:tb]"}
{"concept_id": "C3268990", "aliases": [], "types": ["T043"], "canonical_name": "molybdate ion export from vacuole", "definition": "The directed movement of molybdate ions out of the vacuole. [GOC:tb]"}
{"concept_id": "C3268991", "aliases": [], "types": ["T044"], "canonical_name": "7-hydroxymethyl chlorophyll a reductase activity", "definition": "Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O. [GOC:kad, PMID:21934147]"}
{"concept_id": "C3268992", "aliases": [], "types": ["T044"], "canonical_name": "nicotinate transmembrane transporter activity", "definition": "Enables the transfer of nicotinate from one side of a membrane to the other. [GOC:tb]"}
{"concept_id": "C3268993", "aliases": [], "types": ["T044"], "canonical_name": "N-methylnicotinate transporter activity"}
{"concept_id": "C3269003", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription involved in G2/M transition of mitotic cell cycle", "definition": "Any process that inhibits or decreases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle. [GOC:mtg_cell_cycle, PMID:10747051]"}
{"concept_id": "C3269007", "aliases": ["dendritic spine organisation"], "types": ["T043"], "canonical_name": "dendritic spine organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. [GOC:BHF, PMID:20410104]"}
{"concept_id": "C3269008", "aliases": [], "types": ["T043"], "canonical_name": "dendritic spine maintenance", "definition": "The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. [GOC:BHF, PMID:20410104]"}
{"concept_id": "C3269009", "aliases": [], "types": ["T044"], "canonical_name": "cadmium ion sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++). [GOC:rs, PMID:19456862]"}
{"concept_id": "C3269010", "aliases": ["non-coding RNA export from nucleus"], "types": ["T043"], "canonical_name": "ncRNA export from nucleus", "definition": "The directed movement of a non-coding RNA transcript (ncRNA) from the nucleus to the cytoplasm. [GOC:dgf, PMID:11352936]"}
{"concept_id": "C3269011", "aliases": [], "types": ["T042"], "canonical_name": "anterior head development", "definition": "The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure. [GOC:yaf, PMID:14695376, PMID:15857913]"}
{"concept_id": "C3269012", "aliases": ["response to thyroid hormone stimulus"], "types": ["T043"], "canonical_name": "response to thyroid hormone", "definition": "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. [GOC:sjw, PMID:9916872]"}
{"concept_id": "C3269013", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to thyroid hormone stimulus", "definition": "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. [GOC:sjw, PMID:9916872]"}
{"concept_id": "C3269014", "aliases": ["response to T4 stimulus", "response to thyroxine stimulus", "response to T4"], "types": ["T043"], "canonical_name": "response to thyroxine", "definition": "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. [GOC:sjw, PMID:9916872]"}
{"concept_id": "C3269015", "aliases": ["cellular response to T4 stimulus"], "types": ["T043"], "canonical_name": "cellular response to thyroxine stimulus", "definition": "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. [GOC:sjw, PMID:9916872]"}
{"concept_id": "C3269016", "aliases": [], "types": ["T042"], "canonical_name": "ductus arteriosus closure", "definition": "The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs. [GOC:hw]"}
{"concept_id": "C3269017", "aliases": ["interferon regulatory factor complex location", "IRF complex location", "IRF complex"], "types": ["T026"], "canonical_name": "interferon regulatory factor complex", "definition": "A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. [GOC:cna, PMID:20043992]"}
{"concept_id": "C3269018", "aliases": ["IRF3:IRF3 complex", "IRF3:IRF3 complex location", "interferon regulatory factor 3 complex location"], "types": ["T026"], "canonical_name": "interferon regulatory factor 3 complex", "definition": "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3. [GOC:cna, PMID:12855817, PMID:14556004, Reactome:R-HSA-166272]"}
{"concept_id": "C3269019", "aliases": ["interferon regulatory factor 5 complex location", "IRF5:IRF5 complex location", "IRF5:IRF5 complex"], "types": ["T026"], "canonical_name": "interferon regulatory factor 5 complex", "definition": "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5. [GOC:cna, PMID:12138184, PMID:16751392]"}
{"concept_id": "C3269020", "aliases": ["IRF7:IRF7 complex location", "IRF7:IRF7 complex", "interferon regulatory factor 7 complex location"], "types": ["T026"], "canonical_name": "interferon regulatory factor 7 complex", "definition": "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7. [GOC:cna, PMID:18068231, Reactome:R-HSA-450344]"}
{"concept_id": "C3269021", "aliases": ["interferon regulatory factor 3-interferon regulatory factor 7 complex location", "IRF3:IRF7 complex location", "IRF3:IRF7 complex"], "types": ["T026"], "canonical_name": "interferon regulatory factor 3-interferon regulatory factor 7 complex", "definition": "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7. [GOC:cna, PMID:18068231, Reactome:R-HSA-1027367]"}
{"concept_id": "C3269022", "aliases": ["TAK1 kinase complex location", "TAK1 kinase complex", "transforming growth factor beta activated kinase 1 complex location"], "types": ["T026"], "canonical_name": "transforming growth factor beta activated kinase 1 complex", "definition": "A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits). [GOC:cna, PMID:16410796, PMID:17496917, PMID:18021073]"}
{"concept_id": "C3269023", "aliases": [], "types": ["T044"], "canonical_name": "copper ion sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+). [GOC:rs, PMID:19928961]"}
{"concept_id": "C3269024", "aliases": ["FAL1-SGD1 complex location"], "types": ["T026"], "canonical_name": "FAL1-SGD1 complex", "definition": "A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits. [GOC:rb, PMID:21576267]"}
{"concept_id": "C3269025", "aliases": ["selenite:H+ symporter activity", "selenite:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "selenite:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in). [GOC:mcc, PMID:20861301]"}
{"concept_id": "C3269026", "aliases": ["plasma membrane hydrogenselenite transport"], "types": ["T043"], "canonical_name": "plasma membrane selenite transport", "definition": "The directed movement of inorganic selenite (HSeO3-1 at physiological pH) across a plasma membrane. [GOC:mcc, PMID:20861301]"}
{"concept_id": "C3269027", "aliases": ["vascular smooth muscle cell fate commitment"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell fate commitment", "definition": "The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. [GOC:BHF]"}
{"concept_id": "C3269028", "aliases": ["vascular smooth muscle cell fate specification"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. [GOC:BHF]"}
{"concept_id": "C3269029", "aliases": ["vascular smooth muscle cell fate determination"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell fate determination", "definition": "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. [GOC:BHF]"}
{"concept_id": "C3269030", "aliases": ["vascular smooth muscle cell development"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell development", "definition": "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. [GOC:BHF]"}
{"concept_id": "C3269031", "aliases": ["IRF3:IRF5 complex", "interferon regulatory factor 3-interferon regulatory factor 5 complex location", "IRF3:IRF5 complex location"], "types": ["T026"], "canonical_name": "interferon regulatory factor 3-interferon regulatory factor 5 complex", "definition": "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5. [GOC:cna, PMID:12138184]"}
{"concept_id": "C3269032", "aliases": [], "types": ["T043"], "canonical_name": "amniotic stem cell differentiation", "definition": "The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone. [CL:0002639, GOC:yaf, PMID:20942606, Wikipedia:Amniotic_stem_cells]"}
{"concept_id": "C3269033", "aliases": ["IL-17A production"], "types": ["T044"], "canonical_name": "interleukin-17A production", "definition": "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv, PMID:27901018]"}
{"concept_id": "C3269034", "aliases": ["IL-17F production"], "types": ["T044"], "canonical_name": "interleukin-17F production", "definition": "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv, Wikipedia:Interleukin_17]"}
{"concept_id": "C3269035", "aliases": ["methyl-branched fatty acid metabolism"], "types": ["T044"], "canonical_name": "methyl-branched fatty acid metabolic process", "definition": "The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain. [GOC:rs, PMID:19933331]"}
{"concept_id": "C3269036", "aliases": ["pre-synaptic membrane organization", "presynaptic membrane organisation"], "types": ["T043"], "canonical_name": "presynaptic membrane organization", "definition": "A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. [GOC:BHF, GOC:pr, GOC:sjp, PMID:19730411]"}
{"concept_id": "C3269037", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle clustering", "definition": "The process that results in grouping synaptic vesicles in presynaptic structures. [GOC:ans, GOC:pr, PMID:19900895, PMID:7568108]"}
{"concept_id": "C3269038", "aliases": ["polyacyltrehalose metabolism"], "types": ["T044"], "canonical_name": "polyacyltrehalose metabolic process", "definition": "The chemical reactions and pathways involving polyacyltrehalose, a pentaacylated, trehalose-based glycolipid. [GOC:rs, PMID:19729090]"}
{"concept_id": "C3269039", "aliases": ["polyacyltrehalose biosynthesis", "polyacyltrehalose anabolism", "polyacyltrehalose synthesis", "polyacyltrehalose formation"], "types": ["T044"], "canonical_name": "polyacyltrehalose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid. [GOC:rs, PMID:19729090]"}
{"concept_id": "C3269040", "aliases": [], "types": ["T042"], "canonical_name": "craniofacial suture morphogenesis", "definition": "The process in which any suture between cranial and/or facial bones is generated and organized. [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]"}
{"concept_id": "C3269041", "aliases": ["nasofrontal suture morphogenesis"], "types": ["T042"], "canonical_name": "frontonasal suture morphogenesis", "definition": "The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized. [GOC:pr, GOC:sl, PMID:12416537, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]"}
{"concept_id": "C3269042", "aliases": [], "types": ["T042"], "canonical_name": "facial suture morphogenesis", "definition": "The process in which any suture between facial bones is generated and organized. [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]"}
{"concept_id": "C3269043", "aliases": ["internasal suture morphogenesis"], "types": ["T042"], "canonical_name": "nasal suture morphogenesis", "definition": "The process in which the nasal suture is generated and organized. [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]"}
{"concept_id": "C3269044", "aliases": [], "types": ["T045"], "canonical_name": "DNA/RNA hybrid annealing activity", "definition": "An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops. [GOC:imk, PMID:21699496]"}
{"concept_id": "C3269045", "aliases": ["structural constituent of egg white"], "types": ["T044"], "canonical_name": "structural constituent of albumen", "definition": "The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo. [GOC:jj, Wikipedia:Albumen]"}
{"concept_id": "C3269046", "aliases": [], "types": ["T045"], "canonical_name": "supercoiled DNA binding", "definition": "Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. [GOC:pr, GOC:rph, PMID:20723754, PMID:21345933, Wikipedia:DNA_supercoil]"}
{"concept_id": "C3269047", "aliases": [], "types": ["T043"], "canonical_name": "blood vessel endothelial cell fate specification", "definition": "The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. [CL:0002139, GOC:dgh, PMID:21521739]"}
{"concept_id": "C3269048", "aliases": ["angiogenic tip cell fate specification"], "types": ["T043"], "canonical_name": "endothelial tip cell fate specification", "definition": "The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels. [CL:0000704, GOC:dgh, PMID:21521739]"}
{"concept_id": "C3269049", "aliases": ["angiogenic stalk cell fate specification"], "types": ["T043"], "canonical_name": "endothelial stalk cell fate specification", "definition": "The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout. [CL:0002671, GOC:dgh, PMID:21521739]"}
{"concept_id": "C3269050", "aliases": ["post-synaptic membrane assembly"], "types": ["T043"], "canonical_name": "postsynaptic membrane assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). [GOC:BHF, GOC:sjp, PMID:21424692]"}
{"concept_id": "C3269051", "aliases": ["pre-synaptic membrane assembly"], "types": ["T043"], "canonical_name": "presynaptic membrane assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. [GOC:BHF, GOC:pr, GOC:sjp, PMID:15797875, PMID:18550748]"}
{"concept_id": "C3269052", "aliases": ["post synaptic density organization", "postsynaptic density organisation", "PSD organization", "post-synaptic specialization organization", "post-synaptic density organization", "postsynaptic specialization organization", "postsynaptic specialization organisation", "post synaptic specialization organization"], "types": ["T043"], "canonical_name": "postsynaptic density organization", "definition": "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. [GOC:BHF, GOC:sjp, PMID:21525273]"}
{"concept_id": "C3269053", "aliases": ["post-synaptic density assembly", "PSD assembly", "post synaptic density assembly"], "types": ["T042"], "canonical_name": "postsynaptic density assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. [GOC:BHF, GOC:sjp, PMID:21525273]"}
{"concept_id": "C3269054", "aliases": [], "types": ["T044"], "canonical_name": "hedgehog family protein binding", "definition": "Binding to a member of the hedgehog protein family, signaling proteins involved in development. [GOC:BHF, GOC:pr, PMID:10050855]"}
{"concept_id": "C3269055", "aliases": [], "types": ["T044"], "canonical_name": "neuroligin family protein binding", "definition": "Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation. [GOC:BHF, GOC:pr, GOC:sjp, PMID:21424692]"}
{"concept_id": "C3269056", "aliases": [], "types": ["T044"], "canonical_name": "scaffold protein binding", "definition": "Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]"}
{"concept_id": "C3269057", "aliases": ["ERGIC organization", "ER-Golgi intermediate compartment organization", "endoplasmic reticulum-Golgi intermediate compartment organisation"], "types": ["T043"], "canonical_name": "endoplasmic reticulum-Golgi intermediate compartment organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment. [GOC:br, PMID:18287528]"}
{"concept_id": "C3269058", "aliases": [], "types": ["T043"], "canonical_name": "endoplasmic reticulum-Golgi intermediate compartment organization and biogenesis"}
{"concept_id": "C3269059", "aliases": ["GABA receptor clustering"], "types": ["T044"], "canonical_name": "gamma-aminobutyric acid receptor clustering", "definition": "The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane. [GOC:BHF, GOC:sjp, PMID:15620359]"}
{"concept_id": "C3269060", "aliases": ["AMPA receptor clustering", "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering"], "types": ["T044"], "canonical_name": "AMPA glutamate receptor clustering", "definition": "The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane. [GOC:BHF, GOC:pr, GOC:sjp, PMID:12796785]"}
{"concept_id": "C3269061", "aliases": ["N-methyl-D-aspartate receptor clustering", "NMDA receptor clustering"], "types": ["T044"], "canonical_name": "NMDA glutamate receptor clustering", "definition": "The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane. [GOC:BHF, GOC:sjp, PMID:15620359]"}
{"concept_id": "C3269062", "aliases": ["Nrxn clustering"], "types": ["T043"], "canonical_name": "neurexin clustering"}
{"concept_id": "C3269063", "aliases": [], "types": ["T043"], "canonical_name": "Geph clustering"}
{"concept_id": "C3269064", "aliases": ["GKAP clustering"], "types": ["T043"], "canonical_name": "guanylate kinase-associated protein clustering", "definition": "The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons. [GOC:BHF, GOC:sjp, PMID:15620359]"}
{"concept_id": "C3269065", "aliases": ["Nlgn clustering"], "types": ["T043"], "canonical_name": "neuroligin clustering"}
{"concept_id": "C3269066", "aliases": ["Dlg4 clustering", "post-synaptic density protein 95 clustering", "PSD-95 clustering"], "types": ["T043"], "canonical_name": "postsynaptic density protein 95 clustering", "definition": "The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. [GOC:BHF, GOC:sjp, PMID:10433269]"}
{"concept_id": "C3269067", "aliases": ["receptor localisation to synapse"], "types": ["T043"], "canonical_name": "receptor localization to synapse", "definition": "Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:BHF, GOC:sjp, PMID:21525273]"}
{"concept_id": "C3269068", "aliases": ["cyclin A1-CDK1 complex location"], "types": ["T026"], "canonical_name": "cyclin A1-CDK1 complex", "definition": "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269069", "aliases": ["cyclin A2-CDK1 complex location"], "types": ["T026"], "canonical_name": "cyclin A2-CDK1 complex", "definition": "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269070", "aliases": ["cyclin A1-CDK2 complex location"], "types": ["T026"], "canonical_name": "cyclin A1-CDK2 complex", "definition": "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269071", "aliases": ["cyclin A2-CDK2 complex location"], "types": ["T026"], "canonical_name": "cyclin A2-CDK2 complex", "definition": "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269072", "aliases": ["cyclin B1-CDK1 complex location"], "types": ["T026"], "canonical_name": "cyclin B1-CDK1 complex", "definition": "A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269073", "aliases": ["cyclin B2-CDK1 complex location"], "types": ["T026"], "canonical_name": "cyclin B2-CDK1 complex", "definition": "A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269074", "aliases": ["cyclin B3-CDK2 complex location"], "types": ["T026"], "canonical_name": "cyclin B3-CDK2 complex", "definition": "A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269075", "aliases": ["cyclin D1-CDK4 complex location"], "types": ["T026"], "canonical_name": "cyclin D1-CDK4 complex", "definition": "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269076", "aliases": ["cyclin D2-CDK4 complex location"], "types": ["T026"], "canonical_name": "cyclin D2-CDK4 complex", "definition": "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269077", "aliases": ["cyclin D3-CDK4 complex location"], "types": ["T026"], "canonical_name": "cyclin D3-CDK4 complex", "definition": "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269078", "aliases": ["cyclin D1-CDK6 complex location"], "types": ["T026"], "canonical_name": "cyclin D1-CDK6 complex", "definition": "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269079", "aliases": ["cyclin D2-CDK6 complex location"], "types": ["T026"], "canonical_name": "cyclin D2-CDK6 complex", "definition": "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269080", "aliases": ["cyclin D3-CDK6 complex location"], "types": ["T026"], "canonical_name": "cyclin D3-CDK6 complex", "definition": "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269081", "aliases": ["cyclin E1-CDK2 complex location"], "types": ["T026"], "canonical_name": "cyclin E1-CDK2 complex", "definition": "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269082", "aliases": ["cyclin E2-CDK2 complex location"], "types": ["T026"], "canonical_name": "cyclin E2-CDK2 complex", "definition": "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]"}
{"concept_id": "C3269083", "aliases": ["Bcl-2 family protein complex location"], "types": ["T026"], "canonical_name": "Bcl-2 family protein complex", "definition": "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269084", "aliases": ["BAD-BCL-xl complex location"], "types": ["T026"], "canonical_name": "BAD-BCL-xl complex", "definition": "A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269085", "aliases": ["BAD-BCL-2 complex location"], "types": ["T026"], "canonical_name": "BAD-BCL-2 complex", "definition": "A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269086", "aliases": ["BID-BCL-2 complex location"], "types": ["T026"], "canonical_name": "BID-BCL-2 complex", "definition": "A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269087", "aliases": ["BIM-BCL-xl complex location"], "types": ["T026"], "canonical_name": "BIM-BCL-xl complex", "definition": "A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269088", "aliases": ["BIM-BCL-2 complex location"], "types": ["T026"], "canonical_name": "BIM-BCL-2 complex", "definition": "A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269089", "aliases": ["PUMA-BCL-2 complex location"], "types": ["T026"], "canonical_name": "PUMA-BCL-2 complex", "definition": "A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269090", "aliases": ["PUMA-BCL-xl complex location"], "types": ["T026"], "canonical_name": "PUMA-BCL-xl complex", "definition": "A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269091", "aliases": ["BAX complex location"], "types": ["T026"], "canonical_name": "BAX complex", "definition": "An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269092", "aliases": ["BAK complex location"], "types": ["T026"], "canonical_name": "BAK complex", "definition": "An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269093", "aliases": ["NOXA-BCL-xl complex location"], "types": ["T026"], "canonical_name": "NOXA-BCL-xl complex", "definition": "A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269094", "aliases": ["NOXA-BCL-2 complex location"], "types": ["T026"], "canonical_name": "NOXA-BCL-2 complex", "definition": "A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:so, PMID:14634621]"}
{"concept_id": "C3269095", "aliases": ["BCL-2 complex location"], "types": ["T026"], "canonical_name": "BCL-2 complex", "definition": "A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:bhm, GOC:so, PMID:14634621]"}
{"concept_id": "C3269096", "aliases": ["centralspindlin complex location"], "types": ["T026"], "canonical_name": "centralspindlin complex", "definition": "A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals). [GOC:ans, PMID:11782313, PMID:16236794]"}
{"concept_id": "C3269097", "aliases": [], "types": ["T040"], "canonical_name": "neuronal stem cell population maintenance", "definition": "Any process in by an organism or tissue maintains a population of neuronal stem cells. [CL:0000047, GOC:dos, GOC:yaf, PMID:11399758]"}
{"concept_id": "C3269098", "aliases": ["positive regulation of inhibitory post-synaptic membrane potential", "positive regulation of IPSP"], "types": ["T043"], "canonical_name": "positive regulation of inhibitory postsynaptic potential", "definition": "Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. [GOC:BHF, GOC:sjp, PMID:18550748]"}
{"concept_id": "C3269099", "aliases": ["mesenchymal cell apoptosis"], "types": ["T043"], "canonical_name": "mesenchymal cell apoptotic process", "definition": "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833]"}
{"concept_id": "C3269100", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type endopeptidase activity involved in apoptotic process", "definition": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. [GOC:mtg_apoptosis]"}
{"concept_id": "C3269101", "aliases": [], "types": ["T043"], "canonical_name": "GABAergic neuron differentiation", "definition": "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. [GOC:kmv, PMID:11517269]"}
{"concept_id": "C3269102", "aliases": [], "types": ["T043"], "canonical_name": "fasciculation of sensory neuron axon", "definition": "The collection of sensory neuron axons into a bundle of rods, known as a fascicle. [GOC:lb, PMID:18403711]"}
{"concept_id": "C3269103", "aliases": [], "types": ["T043"], "canonical_name": "fasciculation of motor neuron axon", "definition": "The collection of motor neuron axons into a bundle of rods, known as a fascicle. [GOC:lb, PMID:18403711]"}
{"concept_id": "C3269104", "aliases": ["pre-messenger RNA intronic binding"], "types": ["T045"], "canonical_name": "pre-mRNA intronic binding", "definition": "Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA). [GOC:ans, PMID:16260624]"}
{"concept_id": "C3269105", "aliases": ["pre-messenger RNA intronic pyrimidine-rich binding"], "types": ["T045"], "canonical_name": "pre-mRNA intronic pyrimidine-rich binding", "definition": "Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA). [GOC:ans, PMID:16260624, PMID:16777844]"}
{"concept_id": "C3269106", "aliases": [], "types": ["T044"], "canonical_name": "organic cyclic compound binding", "definition": "Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. [GOC:sjw, PMID:7583672]"}
{"concept_id": "C3269107", "aliases": ["polychlorobiphenyl binding", "PCB binding"], "types": ["T044"], "canonical_name": "polychlorinated biphenyl binding", "definition": "Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings. [GOC:sjw, PMID:7583672]"}
{"concept_id": "C3269108", "aliases": [], "types": ["T044"], "canonical_name": "DH domain binding", "definition": "Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket. [GOC:yaf, InterPro:IPR000219, PMID:12775584]"}
{"concept_id": "C3269109", "aliases": [], "types": ["T044"], "canonical_name": "MADS box domain binding", "definition": "Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs. [GOC:yaf, InterPro:IPR002100, PMID:18296735, Wikipedia:MADS-box]"}
{"concept_id": "C3269110", "aliases": [], "types": ["T044"], "canonical_name": "sulfur carrier activity", "definition": "Covalently binding to sulfur and delivering it to an acceptor molecule. [GOC:imk, PMID:16387657]"}
{"concept_id": "C3269111", "aliases": ["ammonium ion metabolism", "ammonium metabolic process"], "types": ["T044"], "canonical_name": "ammonium ion metabolic process", "definition": "The chemical reactions and pathways involving the ammonium ion. [GOC:dhl, GOC:tb, PMID:14671018]"}
{"concept_id": "C3269112", "aliases": [], "types": ["T026"], "canonical_name": "nuclear stress granule", "definition": "A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress. [GOC:ans, PMID:10359787, PMID:12865437]"}
{"concept_id": "C3269113", "aliases": [], "types": ["T043"], "canonical_name": "lens epithelial cell proliferation", "definition": "The multiplication or reproduction of lens epithelial cells, resulting in the expansion of a cell population. Lens epithelial cells make up the lens epithelium, which is located in the anterior portion of the lens between the lens capsule and the lens fibers and is a simple cuboidal epithelium. The epithelial cells of the lens regulate most of the homeostatic functions of the lens such as osmolarity and liquid volume. The lens epithelial cells also serve as the progenitors for new lens fibers. The lens epithelium constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. [CL:0002224, GOC:yaf, PMID:18423449, Wikipedia:Lens_%28anatomy%29#Lens_epithelium]"}
{"concept_id": "C3269114", "aliases": ["regulation of mRNA translation in response to circadian clock"], "types": ["T043"], "canonical_name": "circadian regulation of translation", "definition": "Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours. [GOC:ans, PMID:17264215]"}
{"concept_id": "C3269115", "aliases": ["MSC proliferation"], "types": ["T043"], "canonical_name": "mesenchymal stem cell proliferation", "definition": "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [CL:0000134, GOC:yaf, PMID:20626275]"}
{"concept_id": "C3269116", "aliases": ["AIM2 inflammasome complex location"], "types": ["T026"], "canonical_name": "AIM2 inflammasome complex", "definition": "An inflammasome complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA. [GOC:vp, PMID:20303873]"}
{"concept_id": "C3269117", "aliases": ["ADP-L-glycero-beta-D-manno-heptose metabolism"], "types": ["T044"], "canonical_name": "ADP-L-glycero-beta-D-manno-heptose metabolic process", "definition": "The chemical reactions and pathways involving ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate. [GOC:yaf]"}
{"concept_id": "C3269118", "aliases": ["ADP-L-glycero-beta-D-manno-heptose formation", "ADP-L-glycero-beta-D-manno-heptose anabolism", "ADP-L-glycero-beta-D-manno-heptose synthesis", "ADP-L-glycero-beta-D-manno-heptose biosynthesis"], "types": ["T044"], "canonical_name": "ADP-L-glycero-beta-D-manno-heptose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate. [GOC:yaf, UniPathway:UPA00356]"}
{"concept_id": "C3269119", "aliases": ["N-acetylmuramate metabolism", "N-acetylmuramic acid metabolism", "N-acetylmuramate metabolic process"], "types": ["T044"], "canonical_name": "N-acetylmuramic acid metabolic process", "definition": "The chemical reactions and pathways involving N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine. [GOC:yaf]"}
{"concept_id": "C3269120", "aliases": ["N-acetylmuramate degradation", "N-acetylmuramic acid catabolism", "N-acetylmuramate catabolic process", "N-acetylmuramate catabolism", "N-acetylmuramic acid degradation", "N-acetylmuramate breakdown", "N-acetylmuramic acid breakdown"], "types": ["T044"], "canonical_name": "N-acetylmuramic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine. [GOC:yaf, UniPathway:UPA00342]"}
{"concept_id": "C3269121", "aliases": ["1,6-anhydro-N-acetylmuramic acid metabolism", "1,6-anhydro-N-acetyl-beta-muramate metabolic process", "1,6-anhydro-N-acetyl-beta-muramic acid metabolism", "1,6-anhydro-N-acetyl-beta-muramate metabolism", "1,6-anhydro-N-acetylmuramic acid metabolic process"], "types": ["T044"], "canonical_name": "1,6-anhydro-N-acetyl-beta-muramic acid metabolic process", "definition": "The chemical reactions and pathways involving 1,6-anhydro-N-acetyl-beta-muramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid. [GOC:yaf, PMID:15901686]"}
{"concept_id": "C3269122", "aliases": ["1,6-anhydro-N-acetylmuramate catabolic process", "1,6-anhydro-N-acetyl-beta-muramic acid breakdown", "1,6-anhydro-N-acetylmuramic acid catabolic process", "1,6-anhydro-N-acetylmuramic acid catabolism", "1,6-anhydro-N-acetylmuramate degradation", "1,6-anhydro-N-acetyl-beta-muramic acid degradation", "1,6-anhydro-N-acetyl-beta-muramate degradation", "1,6-anhydro-N-acetylmuramic acid degradation", "1,6-anhydro-N-acetyl-beta-muramate breakdown", "1,6-anhydro-N-acetylmuramate breakdown", "1,6-anhydro-N-acetyl-beta-muramic acid catabolism", "1,6-anhydro-N-acetyl-beta-muramate catabolic process", "1,6-anhydro-N-acetylmuramate catabolism", "1,6-anhydro-N-acetylmuramic acid breakdown", "1,6-anhydro-N-acetyl-beta-muramate catabolism"], "types": ["T044"], "canonical_name": "1,6-anhydro-N-acetyl-beta-muramic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1,6-anhydro-N-acetylmuramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid. [GOC:yaf, PMID:15901686, UniPathway:UPA00343]"}
{"concept_id": "C3269123", "aliases": ["epoxide metabolism"], "types": ["T044"], "canonical_name": "epoxide metabolic process", "definition": "The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers. [GOC:rs, PMID:15822179]"}
{"concept_id": "C3269124", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial ribosome binding", "definition": "Binding to a mitochondrial ribosome. [GOC:ans, PMID:20739282]"}
{"concept_id": "C3269125", "aliases": ["membrane ruffle formation", "membrane ruffling"], "types": ["T043"], "canonical_name": "ruffle assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. [GOC:yaf, http:en.wikipedia.org/wiki/Membrane_ruffling, PMID:12556481]"}
{"concept_id": "C3269126", "aliases": ["protease inhibitor complex", "peptidase inhibitor complex", "peptidase inhibitor complex location"], "types": ["T026"], "definition": "A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity. [GOC:ans, PMID:6323392]", "canonical_name": "protease inhibitor complex location"}
{"concept_id": "C3269127", "aliases": ["serpin complex location", "serine-type endopeptidase inhibitor complex location", "serine protease inhibitor complex location", "serine-type endopeptidase inhibitor complex", "serpin complex"], "types": ["T026"], "canonical_name": "serine protease inhibitor complex", "definition": "A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity. [GOC:ans, PMID:6323392]"}
{"concept_id": "C3269128", "aliases": ["protein C inhibitor-F5 complex location", "SERPINA5-coagulation factor V complex", "SERPINA5-coagulation factor V complex location", "protein C inhibitor-F5 complex", "protein C inhibitor-coagulation factor V complex location", "PCI-coagulation factor V complex", "plasma serine protease inhibitor-coagulation factor V complex location", "plasma serine protease inhibitor-coagulation factor V complex", "serpin A5-coagulation factor V complex location", "serpin A5-coagulation factor V complex", "PCI-coagulation factor V complex location"], "types": ["T026"], "canonical_name": "protein C inhibitor-coagulation factor V complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V. [GOC:ans, PMID:6323392]"}
{"concept_id": "C3269129", "aliases": ["serpin A5-coagulation factor Xa complex location", "SERPINA5-coagulation factor Xa complex location", "plasma serine protease inhibitor-coagulation factor Xa complex location", "serpin A5-coagulation factor Xa complex", "plasma serine protease inhibitor-coagulation factor Xa complex", "protein C inhibitor-coagulation factor Xa complex location", "PCI-coagulation factor Xa complex location", "SERPINA5-coagulation factor Xa complex", "PCI-coagulation factor Xa complex"], "types": ["T026"], "canonical_name": "protein C inhibitor-coagulation factor Xa complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa. [GOC:ans, PMID:6323392]"}
{"concept_id": "C3269130", "aliases": ["serpin A5-coagulation factor XI complex location", "plasma serine protease inhibitor-coagulation factor XI complex", "SERPINA5-coagulation factor XI complex", "PCI-coagulation factor XI complex", "serpin A5-coagulation factor XI complex", "protein C inhibitor-coagulation factor XI complex location", "PCI-coagulation factor XI complex location", "protein C inhibitor-F11 complex location", "protein C inhibitor-F11 complex", "plasma serine protease inhibitor-coagulation factor XI complex location", "SERPINA5-coagulation factor XI complex location"], "types": ["T026"], "canonical_name": "protein C inhibitor-coagulation factor XI complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI. [GOC:ans, PMID:2844223]"}
{"concept_id": "C3269131", "aliases": [], "types": ["T043"], "canonical_name": "response to azide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus. [GOC:yaf, PMID:16846222]"}
{"concept_id": "C3269132", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to azide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus. [GOC:yaf, PMID:16846222]"}
{"concept_id": "C3269133", "aliases": ["dentine mineralization"], "types": ["T042"], "canonical_name": "dentin mineralization", "definition": "The process in which calcium salts are deposited into the calcareous tooth structure known as dentin. [GOC:sl, PMID:10206335, PMID:21196346]"}
{"concept_id": "C3269134", "aliases": ["apoptotic vesicle"], "types": ["T026"], "definition": "A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um. [GOC:mtg_apoptosis, GOC:vesicles, PMID:15242875, PMID:24223256, Wikipedia:Apoptosis, Wikipedia:Bleb_(cell_biology)]", "canonical_name": "apoptotic body"}
{"concept_id": "C3269135", "aliases": ["induction of apoptosis by extracellular signals", "apoptotic signalling pathway"], "types": ["T043"], "canonical_name": "apoptotic signaling pathway", "definition": "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis]"}
{"concept_id": "C3269136", "aliases": ["extrinsic apoptotic pathway", "extrinsic apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "extrinsic apoptotic signaling pathway", "definition": "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]"}
{"concept_id": "C3269137", "aliases": ["death receptor-mediated apoptosis"], "types": ["T043"], "canonical_name": "death receptor-mediated apoptosis"}
{"concept_id": "C3269138", "aliases": [], "types": ["T044"], "canonical_name": "extrinsic apoptosis"}
{"concept_id": "C3269139", "aliases": [], "types": ["T044"], "canonical_name": "extrinsic apoptotic signaling pathway in presence of ligand"}
{"concept_id": "C3269140", "aliases": ["extrinsic apoptotic signalling pathway in absence of ligand"], "types": ["T043"], "canonical_name": "extrinsic apoptotic signaling pathway in absence of ligand", "definition": "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]"}
{"concept_id": "C3269141", "aliases": ["dependence receptor signaling pathway"], "types": ["T043"], "canonical_name": "dependence receptor signaling pathway"}
{"concept_id": "C3269142", "aliases": [], "types": ["T043"], "canonical_name": "extrinsic apoptosis in absence of ligand"}
{"concept_id": "C3269143", "aliases": ["intrinsic apoptotic pathway", "mitochondrial-mediated apoptotic pathway", "intrinsic apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "intrinsic apoptotic signaling pathway", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]"}
{"concept_id": "C3269144", "aliases": [], "types": ["T044"], "canonical_name": "intrinsic apoptosis"}
{"concept_id": "C3269145", "aliases": ["execution phase of apoptotic process"], "types": ["T043"], "canonical_name": "execution phase of apoptosis", "definition": "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:mtg_apoptosis, PMID:21760595]"}
{"concept_id": "C3269146", "aliases": ["Shu complex location"], "types": ["T026"], "canonical_name": "Shu complex", "definition": "A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p. [GOC:jh, PMID:15654096, PMID:19496932]"}
{"concept_id": "C3269147", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K36 trimethylation", "definition": "The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone. [GOC:se, PMID:17948059]"}
{"concept_id": "C3269148", "aliases": ["cysteine-type endopeptidase activity involved in apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "cysteine-type endopeptidase activity involved in apoptotic signaling pathway", "definition": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway. [GOC:mtg_apoptosis, PMID:11717445, Wikipedia:Caspase]"}
{"concept_id": "C3269149", "aliases": [], "types": ["T044"], "canonical_name": "apical caspase activity"}
{"concept_id": "C3269150", "aliases": [], "types": ["T044"], "canonical_name": "initiator caspase activity"}
{"concept_id": "C3269151", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type endopeptidase activity involved in execution phase of apoptosis", "definition": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis. [GOC:mtg_apoptosis, Wikipedia:Caspase]"}
{"concept_id": "C3269152", "aliases": [], "types": ["T044"], "canonical_name": "executioner caspase activity"}
{"concept_id": "C3269153", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter in response to stress", "definition": "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:rn, PMID:11027285, PMID:15575969, PMID:16556235, PMID:18086556, PMID:18627600]"}
{"concept_id": "C3269154", "aliases": [], "types": ["T044"], "canonical_name": "activation of cysteine-type endopeptidase activity", "definition": "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. [GOC:mtg_apoptosis, PMID:21726810]"}
{"concept_id": "C3269155", "aliases": [], "types": ["T026"], "canonical_name": "phagocytic cup lip", "definition": "The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. When the two lips of the cup fuse it is converted into a phagosome. [GOC:pf, PMID:20200225]"}
{"concept_id": "C3269156", "aliases": [], "types": ["T026"], "canonical_name": "phagocytic cup base", "definition": "The older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking. [GOC:pf, PMID:20200225]"}
{"concept_id": "C3269157", "aliases": [], "types": ["T039"], "canonical_name": "renal filtration", "definition": "A renal system process in which fluid circulating through the body is filtered through a barrier system. [GOC:pr, GOC:sart]"}
{"concept_id": "C3269158", "aliases": [], "types": ["T039"], "canonical_name": "nephrocyte filtration", "definition": "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm. [GOC:sart, PMID:18971929]"}
{"concept_id": "C3269159", "aliases": ["bud dormancy"], "types": ["T042"], "canonical_name": "bud dormancy process", "definition": "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a bud. Bud dormancy is a suspension of most physiological activity and growth that can be reactivated. It may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. The exit from bud dormancy is marked by the resumed growth of the bud. [GOC:PO_curators, PO_REF:00009]"}
{"concept_id": "C3269160", "aliases": [], "types": ["T026"], "canonical_name": "epidermal lamellar body", "definition": "A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function. [GOC:cjm, Wikipedia:Lamellar_granule]"}
{"concept_id": "C3269161", "aliases": ["response to GnRH"], "types": ["T043"], "canonical_name": "response to gonadotropin-releasing hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. [GOC:yaf, PMID:15976007]"}
{"concept_id": "C3269162", "aliases": ["cellular response to gonadotrophin-releasing hormone", "cellular response to GnRH"], "types": ["T043"], "canonical_name": "cellular response to gonadotropin-releasing hormone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. [GOC:yaf, PMID:15976007]"}
{"concept_id": "C3269163", "aliases": ["lysosome membrane organization", "lysosomal membrane organisation"], "types": ["T043"], "canonical_name": "lysosomal membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:yaf, PMID:20544854]"}
{"concept_id": "C3269164", "aliases": ["regulation of lysosome membrane permeability"], "types": ["T043"], "canonical_name": "regulation of lysosomal membrane permeability", "definition": "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. [GOC:yaf, PMID:20544854]"}
{"concept_id": "C3269165", "aliases": ["positive regulation of lysosome membrane permeability"], "types": ["T043"], "canonical_name": "positive regulation of lysosomal membrane permeability", "definition": "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. [GOC:yaf, PMID:20544854]"}
{"concept_id": "C3269166", "aliases": ["negative regulation of lysosome membrane permeability"], "types": ["T043"], "canonical_name": "negative regulation of lysosomal membrane permeability", "definition": "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. [GOC:yaf, PMID:20544854]"}
{"concept_id": "C3269167", "aliases": ["5'-ppGpp-3' binding"], "types": ["T045"], "canonical_name": "guanosine tetraphosphate binding", "definition": "Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions. [GOC:imk, PMID:15109491, PMID:16968770, PMID:18359660]"}
{"concept_id": "C3269168", "aliases": [], "types": ["T026"], "canonical_name": "sieve area", "definition": "A pit-like area in the cell wall of a sieve element; contains pores lined with callose and occupied by strands of protoplasmic material that interconnect the protoplasts of contiguous sieve elements. [ISBN:0471738433, POC:curators]"}
{"concept_id": "C3269169", "aliases": [], "types": ["T026"], "canonical_name": "sieve plate", "definition": "A part of the cell wall of a sieve tube member that bears one or more highly specialized sieve areas. [ISBN:0471738433, POC:curators]"}
{"concept_id": "C3269170", "aliases": [], "types": ["T026"], "canonical_name": "compound sieve plate", "definition": "A sieve plate that contains several specialized sieve areas in either a scalariform or reticulate arrangement. [ISBN:0471738433, POC:curators]"}
{"concept_id": "C3269171", "aliases": [], "types": ["T026"], "canonical_name": "simple sieve plate", "definition": "A sieve plate that contains a single specialized sieve area. [ISBN:0471738433, POC:curators]"}
{"concept_id": "C3269172", "aliases": ["M/G1 phase-specific MADS box-forkhead transcription factor complex location"], "types": ["T026"], "canonical_name": "M/G1 phase-specific MADS box-forkhead transcription factor complex", "definition": "A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2. [GOC:mah, PMID:18057023]"}
{"concept_id": "C3269173", "aliases": ["PBF complex location"], "types": ["T026"], "canonical_name": "PBF complex"}
{"concept_id": "C3269174", "aliases": ["PBF transcription complex location"], "types": ["T026"], "canonical_name": "PBF transcription complex"}
{"concept_id": "C3269175", "aliases": ["PCB binding factor complex location"], "types": ["T026"], "canonical_name": "PCB binding factor complex"}
{"concept_id": "C3269176", "aliases": ["pombe cell cycle box binding factor complex location"], "types": ["T026"], "canonical_name": "pombe cell cycle box binding factor complex"}
{"concept_id": "C3269177", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial mRNA polyadenylation", "definition": "The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails. [GOC:ans, PMID:18083837]"}
{"concept_id": "C3269179", "aliases": [], "types": ["T026"], "canonical_name": "sperm connecting piece", "definition": "The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum. [GOC:cjm, MP:0009830]"}
{"concept_id": "C3269180", "aliases": [], "types": ["T026"], "canonical_name": "sperm mitochondrial sheath", "definition": "The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. [GOC:cjm, MP:0009832]"}
{"concept_id": "C3269181", "aliases": [], "types": ["T026"], "canonical_name": "sperm annulus", "definition": "The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity. [GOC:cjm, MP:0009834]"}
{"concept_id": "C3269182", "aliases": [], "types": ["T026"], "canonical_name": "sperm principal piece", "definition": "The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. [GOC:cjm, MP:0009836]"}
{"concept_id": "C3269183", "aliases": [], "types": ["T026"], "canonical_name": "sperm end piece", "definition": "The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane. [GOC:cjm, GOC:sart, MP:0009837]"}
{"concept_id": "C3269184", "aliases": ["potassium ion facilitation of cell motility", "K+ facilitation of cell motility"], "types": ["T043"], "canonical_name": "cell motility in response to potassium ion", "definition": "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus. [GOC:pf, PMID:19363786, PMID:21239624]"}
{"concept_id": "C3269185", "aliases": ["calcium ion facilitation of cell motility", "Ca2+ facilitation of cell motility"], "types": ["T043"], "canonical_name": "cell motility in response to calcium ion", "definition": "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus. [GOC:pf, PMID:19363786, PMID:21239624, PMID:8937985]"}
{"concept_id": "C3269186", "aliases": [], "types": ["T026"], "canonical_name": "lamellar body membrane", "definition": "The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. [GOC:sl, PMID:11940594]"}
{"concept_id": "C3269187", "aliases": [], "types": ["T026"], "canonical_name": "alveolar lamellar body membrane", "definition": "The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. [GOC:sl, PMID:11940594]"}
{"concept_id": "C3269188", "aliases": [], "types": ["T026"], "canonical_name": "epidermal lamellar body membrane", "definition": "The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function. [GOC:sl, PMID:11940594]"}
{"concept_id": "C3269192", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to methylglyoxal", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal. [GOC:pr]"}
{"concept_id": "C3269193", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a methylglyoxal stimulus. [GOC:dgf, PMID:15773992]"}
{"concept_id": "C3269194", "aliases": [], "types": ["T043"], "canonical_name": "attachment of chromatin to nuclear envelope"}
{"concept_id": "C3269195", "aliases": ["hemopoietic stem cell migration to bone marrow"], "types": ["T043"], "canonical_name": "hematopoietic stem cell migration to bone marrow", "definition": "The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. [CL:0000037, GOC:yaf, PMID:17368745]"}
{"concept_id": "C3269196", "aliases": [], "types": ["T043"], "canonical_name": "hematopoietic stem cell homing"}
{"concept_id": "C3269197", "aliases": [], "types": ["T043"], "canonical_name": "progenitor cell homing"}
{"concept_id": "C3269198", "aliases": ["beta-amyloid clearance"], "types": ["T038"], "canonical_name": "amyloid-beta clearance", "definition": "The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors. [GOC:aruk, GOC:bc, GOC:BHF, PMID:18289866, PMID:19098903, PMID:26005850]"}
{"concept_id": "C3269199", "aliases": [], "types": ["T044"], "canonical_name": "flavonoid binding", "definition": "Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge. [GOC:sl, PMID:20599706]"}
{"concept_id": "C3269200", "aliases": [], "types": ["T044"], "canonical_name": "flavonol binding", "definition": "Binding to a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone. [GOC:sl]"}
{"concept_id": "C3269201", "aliases": [], "types": ["T044"], "canonical_name": "flavanol binding", "definition": "Binding to a flavanol. [GOC:sl]"}
{"concept_id": "C3269202", "aliases": [], "types": ["T044"], "canonical_name": "flavan-3-ol binding"}
{"concept_id": "C3269203", "aliases": [], "types": ["T044"], "canonical_name": "catechin binding", "definition": "Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure. [GOC:sl]"}
{"concept_id": "C3269204", "aliases": ["EGCG binding"], "types": ["T044"], "canonical_name": "epigallocatechin 3-gallate binding", "definition": "Binding to epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin. [GOC:sl, PMID:21307292]"}
{"concept_id": "C3269205", "aliases": [], "types": ["T044"], "canonical_name": "catechin gallate binding"}
{"concept_id": "C3269206", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of protein location in cell cortex of cell tip", "definition": "A process in which a protein or protein complex is maintained in a specific location in the cell cortex of a cell tip, and is prevented from moving elsewhere. The cell cortex of a cell tip is the region directly beneath the plasma membrane at either end of the longest axis of a cylindrical or elongated cell. [GOC:al, PMID:19646873]"}
{"concept_id": "C3269208", "aliases": ["mitochondrial respiratory supercomplex assembly", "mitochondrial respiratory chain supercomplex assembly"], "types": ["T043"], "canonical_name": "mitochondrial respirasome assembly", "definition": "The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex. [GOC:mcc, PMID:21909073, PMID:22342701]"}
{"concept_id": "C3269209", "aliases": ["LTB4 synthesis", "LTB4 biosynthesis", "leukotriene B4 formation", "LTB4 anabolism", "leukotriene B4 synthesis", "LTB4 formation", "leukotriene B4 anabolism", "leukotriene B4 biosynthesis"], "types": ["T044"], "canonical_name": "leukotriene B4 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. [GOC:yaf, UniPathway:UPA00878]"}
{"concept_id": "C3269210", "aliases": ["oligodendrocyte apoptosis"], "types": ["T043"], "canonical_name": "oligodendrocyte apoptotic process", "definition": "Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons. [CL:0000128, GOC:mtg_apoptosis, GOC:yaf, PMID:16723520]"}
{"concept_id": "C3269211", "aliases": ["(R)-3-hydroxybutyrate transmembrane transporter activity", "3-hydroxybutanoic acid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "beta-hydroxybutyrate transmembrane transporter activity", "definition": "Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid. [GOC:dsf, PMID:22302940]"}
{"concept_id": "C3269212", "aliases": ["R2TP complex location"], "types": ["T026"], "canonical_name": "R2TP complex", "definition": "A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others. [GOC:mcc, PMID:15766533, PMID:21925213]"}
{"concept_id": "C3269213", "aliases": [], "types": ["T044"], "canonical_name": "phenyllactate dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH. [GOC:pde, PMID:10849007, RHEA:38351]"}
{"concept_id": "C3269214", "aliases": ["leukotriene B4 12-hydroxydehydrogenase activity"], "types": ["T044"], "canonical_name": "leukotriene B4 12-hydroxy dehydrogenase activity", "definition": "Catalysis of the reaction: leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+). [GOC:mw, KEGG_REACTION:R03864, PMID:8394361, PMID:9461497]"}
{"concept_id": "C3269215", "aliases": ["20-hydroxy-leukotriene B4 omega-oxidase activity", "20-hydroxy-leukotriene B4 omega-oxidation"], "types": ["T044"], "canonical_name": "20-hydroxy-leukotriene B4 omega oxidase activity", "definition": "Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]. [GOC:mw, PMID:2836406, PMID:9675028, RHEA:48668]"}
{"concept_id": "C3269216", "aliases": [], "types": ["T044"], "canonical_name": "20-aldehyde-leukotriene B4 20-monooxygenase activity", "definition": "Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [GOC:mw, PMID:2549038, PMID:2836406, PMID:9675028, RHEA:48672]"}
{"concept_id": "C3269217", "aliases": [], "types": ["T044"], "canonical_name": "eoxin A4 synthase activity", "definition": "Catalysis of the reaction: leukotriene A4 = eoxin A4. [GOC:mw, PMID:18184802, PMID:18647347]"}
{"concept_id": "C3269218", "aliases": [], "types": ["T044"], "canonical_name": "eoxin C4 synthase activity", "definition": "Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4. [GOC:mw, PMID:18184802, PMID:18647347]"}
{"concept_id": "C3269219", "aliases": [], "types": ["T044"], "canonical_name": "eoxin D4 synthase activity", "definition": "Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid. [GOC:mw, PMID:18184802, PMID:18647347]"}
{"concept_id": "C3269220", "aliases": [], "types": ["T044"], "canonical_name": "eoxin E4 synthase activity", "definition": "Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine. [GOC:mw, PMID:18184802, PMID:18647347]"}
{"concept_id": "C3269221", "aliases": ["self-proteolysis"], "types": ["T044"], "canonical_name": "self proteolysis", "definition": "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. [GOC:yaf, PMID:18676612, PMID:19144634]"}
{"concept_id": "C3269222", "aliases": ["5(S)-HETE dehydrogenase activity", "5-hydroxy-eicosatetraenoic acid dehydrogenase activity", "5-HETE dehydrogenase activity"], "types": ["T044"], "canonical_name": "5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity", "definition": "Catalysis of the reaction: 5-HETE + NADP(+) = 5-oxo-ETE + NADPH + H(+). [GOC:mw, PMID:1326548]"}
{"concept_id": "C3269223", "aliases": ["ring 1,2-phenylacetyl-CoA epoxidase activity", "phenylacetyl-CoA epoxidase activity", "phenylacetyl-CoA monooxygenase activity"], "types": ["T044"], "canonical_name": "phenylacetyl-CoA 1,2-epoxidase activity", "definition": "Catalysis of the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+). [EC:1.14.13.149, GOC:bf, GOC:gk, PMID:20660314, PMID:21247899]"}
{"concept_id": "C3269224", "aliases": ["P450 omega-hydroxylase pathway"], "types": ["T044"], "canonical_name": "omega-hydroxylase P450 pathway", "definition": "The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. [GOC:mw, PMID:10681399]"}
{"concept_id": "C3269225", "aliases": [], "types": ["T026"], "canonical_name": "cytoophidium", "definition": "A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human. [GOC:mag, PMID:20513629, PMID:21930098, Wikipedia:CTP_synthase#Cytoophidium]"}
{"concept_id": "C3269226", "aliases": ["2-trans,6-trans-farnesyl diphosphate activity", "(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity"], "types": ["T044"], "canonical_name": "all-trans-decaprenyl-diphosphate synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate. [GOC:mw, PMID:16262699, RHEA:27802]"}
{"concept_id": "C3269227", "aliases": [], "types": ["T041"], "canonical_name": "dishabituation", "definition": "The temporary recovery of response to a stimulus when a novel stimulus is added. [GOC:kmv, PMID:11390637, Wikipedia:Habituation]"}
{"concept_id": "C3269228", "aliases": ["protein localisation to bud neck", "protein localization to cellular bud neck"], "types": ["T043"], "canonical_name": "protein localization to bud neck", "definition": "A process in which a protein is transported to, or maintained at, a location within a cellular bud neck. [GOC:rb, PMID:22344253]"}
{"concept_id": "C3269229", "aliases": ["ammonia homeostasis"], "types": ["T042"], "canonical_name": "ammonium homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of ammonium. [GOC:yaf, PMID:12695560]"}
{"concept_id": "C3269230", "aliases": [], "types": ["T042"], "canonical_name": "creatinine homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of creatinine. [GOC:yaf, PMID:12695560]"}
{"concept_id": "C3269231", "aliases": [], "types": ["T042"], "canonical_name": "urea homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of urea. [GOC:yaf, PMID:12695560]"}
{"concept_id": "C3269232", "aliases": ["cellular ammonia homeostasis"], "types": ["T043"], "canonical_name": "cellular ammonium homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of ammonium at the level of the cell. [GOC:yaf, PMID:12695560]"}
{"concept_id": "C3269233", "aliases": [], "types": ["T043"], "canonical_name": "cellular creatinine homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of creatinine at the level of the cell. [GOC:yaf, PMID:12695560]"}
{"concept_id": "C3269234", "aliases": [], "types": ["T043"], "canonical_name": "cellular urea homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of urea at the level of the cell. [GOC:yaf, PMID:12695560]"}
{"concept_id": "C3269235", "aliases": ["histamine secretion mediated by IgE antibody"], "types": ["T046"], "canonical_name": "histamine secretion mediated by IgE immunoglobulin", "definition": "Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen. [GOC:add, GOC:rv]"}
{"concept_id": "C3269236", "aliases": [], "types": ["T046"], "canonical_name": "Ig-mediated histamine release"}
{"concept_id": "C3269237", "aliases": [], "types": ["T046"], "canonical_name": "histamine secretion mediated by immunoglobulin", "definition": "Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface. [GOC:add, GOC:rv, PMID:11490155, PMID:1719184]"}
{"concept_id": "C3269238", "aliases": ["immune complex formation"], "types": ["T040"], "definition": "The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus. [GOC:add, GOC:rv]", "canonical_name": "antibody-mediated agglutination"}
{"concept_id": "C3269239", "aliases": ["antibody-mediated neutralization"], "types": ["T044"], "canonical_name": "immunoglobulin-mediated neutralization", "definition": "The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin. [GOC:add, GOC:rv]"}
{"concept_id": "C3269240", "aliases": ["keratinocyte apoptosis"], "types": ["T043"], "canonical_name": "keratinocyte apoptotic process", "definition": "Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. [CL:0000312, GOC:jc, GOC:mtg_apoptosis, PMID:10201527]"}
{"concept_id": "C3269241", "aliases": ["hepatocyte apoptosis"], "types": ["T043"], "canonical_name": "hepatocyte apoptotic process", "definition": "Any apoptotic process in a hepatocyte, the main structural component of the liver. [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020]"}
{"concept_id": "C3269243", "aliases": ["regulation of anthocyanin degradation", "regulation of anthocyanin catabolism", "regulation of anthocyanin breakdown"], "types": ["T044"], "canonical_name": "regulation of anthocyanin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of anthocyanin catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3269244", "aliases": ["negative regulation of anthocyanin catabolism", "down regulation of anthocyanin breakdown", "negative regulation of anthocyanin degradation", "down regulation of anthocyanin catabolism", "negative regulation of anthocyanin breakdown", "down regulation of anthocyanin degradation"], "types": ["T044"], "canonical_name": "negative regulation of anthocyanin catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anthocyanin catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3269245", "aliases": [], "types": ["T044"], "canonical_name": "down regulation of anthocyanin catabolic process"}
{"concept_id": "C3269246", "aliases": ["positive regulation of anthocyanin degradation", "positive regulation of anthocyanin breakdown", "up regulation of anthocyanin degradation", "positive regulation of anthocyanin catabolism", "up regulation of anthocyanin catabolism", "up regulation of anthocyanin breakdown"], "types": ["T044"], "canonical_name": "positive regulation of anthocyanin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of anthocyanin catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3269247", "aliases": [], "types": ["T044"], "canonical_name": "up regulation of anthocyanin catabolic process"}
{"concept_id": "C3269248", "aliases": [], "types": ["T044"], "canonical_name": "regulation of serine-type endopeptidase activity", "definition": "Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity. [GOC:TermGenie]"}
{"concept_id": "C3269249", "aliases": [], "types": ["T044"], "canonical_name": "regulation of blood coagulation factor activity"}
{"concept_id": "C3269250", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of serine-type endopeptidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity. [GOC:TermGenie]"}
{"concept_id": "C3269251", "aliases": [], "types": ["T044"], "canonical_name": "down regulation of blood coagulation factor activity"}
{"concept_id": "C3269252", "aliases": [], "types": ["T044"], "canonical_name": "down regulation of serine-type endopeptidase activity"}
{"concept_id": "C3269253", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of blood coagulation factor activity"}
{"concept_id": "C3269254", "aliases": ["up regulation of serine-type endopeptidase activity"], "types": ["T044"], "canonical_name": "positive regulation of serine-type endopeptidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity. [GOC:TermGenie]"}
{"concept_id": "C3269255", "aliases": ["up regulation of blood coagulation factor activity"], "types": ["T044"], "canonical_name": "positive regulation of blood coagulation factor activity"}
{"concept_id": "C3269256", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of dendrite development", "definition": "Any process that activates or increases the frequency, rate or extent of dendrite development. [GOC:TermGenie]"}
{"concept_id": "C3269266", "aliases": ["regulation of CRH receptor activity", "regulation of CRF receptor activity", "regulation of adrenocorticotropin-releasing hormone receptor activity", "regulation of corticotropin-releasing factor receptor activity"], "types": ["T039"], "canonical_name": "regulation of corticotropin-releasing hormone receptor activity", "definition": "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone receptor activity. [GOC:TermGenie, GOC:yaf, PMID:18234674]"}
{"concept_id": "C3269267", "aliases": ["down regulation of corticotropin-releasing factor receptor activity", "negative regulation of adrenocorticotropin-releasing hormone receptor activity", "negative regulation of corticotropin-releasing factor receptor activity", "down regulation of corticotropin-releasing hormone receptor activity", "down regulation of CRF receptor activity", "negative regulation of CRF receptor activity", "down regulation of adrenocorticotropin-releasing hormone receptor activity", "negative regulation of CRH receptor activity", "down regulation of CRH receptor activity"], "types": ["T039"], "canonical_name": "negative regulation of corticotropin-releasing hormone receptor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity. [GOC:TermGenie, GOC:yaf, PMID:18234674]"}
{"concept_id": "C3269269", "aliases": ["up regulation of corticotropin-releasing hormone receptor activity", "positive regulation of CRH receptor activity", "positive regulation of adrenocorticotropin-releasing hormone receptor activity", "up regulation of CRH receptor activity", "up regulation of adrenocorticotropin-releasing hormone receptor activity", "up regulation of corticotropin-releasing factor receptor activity", "up regulation of CRF receptor activity", "positive regulation of CRF receptor activity", "positive regulation of corticotropin-releasing factor receptor activity"], "types": ["T039"], "canonical_name": "positive regulation of corticotropin-releasing hormone receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of corticotropin-releasing hormone receptor activity. [GOC:TermGenie, GOC:yaf, PMID:18234674]"}
{"concept_id": "C3269274", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cytokine production involved in inflammatory response", "definition": "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]"}
{"concept_id": "C3269275", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cytokine production involved in acute inflammatory response"}
{"concept_id": "C3269276", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cytokine production involved in inflammatory response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]"}
{"concept_id": "C3269277", "aliases": [], "types": ["T040"], "canonical_name": "down regulation of cytokine production involved in acute inflammatory response"}
{"concept_id": "C3269278", "aliases": [], "types": ["T040"], "canonical_name": "down regulation of cytokine production involved in inflammatory response"}
{"concept_id": "C3269279", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cytokine production involved in acute inflammatory response"}
{"concept_id": "C3269280", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of cytokine production involved in inflammatory response", "definition": "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]"}
{"concept_id": "C3269281", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of cytokine production involved in acute inflammatory response"}
{"concept_id": "C3269282", "aliases": [], "types": ["T038"], "canonical_name": "up regulation of cytokine production involved in acute inflammatory response"}
{"concept_id": "C3269283", "aliases": [], "types": ["T038"], "canonical_name": "up regulation of cytokine production involved in inflammatory response"}
{"concept_id": "C3269284", "aliases": [], "types": ["T045"], "canonical_name": "phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex", "definition": "Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex. [GOC:rb, GOC:TermGenie, PMID:10594013, PMID:19666497]"}
{"concept_id": "C3269285", "aliases": ["regulation of PKC activity"], "types": ["T043"], "canonical_name": "regulation of protein kinase C activity", "definition": "Any process that modulates the frequency, rate or extent of protein kinase C activity. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3269286", "aliases": ["positive regulation of PKC activity", "up regulation of PKC activity", "positive regulation of PKC", "up regulation of PKC"], "types": ["T043"], "canonical_name": "positive regulation of protein kinase C activity", "definition": "Any process that activates or increases the frequency, rate or extent of protein kinase C activity. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3269287", "aliases": ["regulation of sphingosine kinase activity"], "types": ["T044"], "canonical_name": "regulation of D-erythro-sphingosine kinase activity", "definition": "Any process that modulates the frequency, rate or extent of D-erythro-sphingosine kinase activity. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3269288", "aliases": ["up regulation of D-erythro-sphingosine kinase activity", "up regulation of sphingosine kinase activity", "positive regulation of sphingosine kinase activity", "regulation of PKC"], "types": ["T044"], "canonical_name": "positive regulation of D-erythro-sphingosine kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of D-erythro-sphingosine kinase activity. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3269289", "aliases": ["regulation of cell spreading during cell substrate adhesion", "regulation of substrate adhesion dependent cell spreading"], "types": ["T043"], "canonical_name": "regulation of substrate adhesion-dependent cell spreading", "definition": "Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269290", "aliases": ["negative regulation of substrate adhesion dependent cell spreading", "down regulation of cell spreading during cell substrate adhesion", "negative regulation of cell spreading during cell substrate adhesion", "down regulation of substrate adhesion dependent cell spreading", "down regulation of substrate adhesion-dependent cell spreading"], "types": ["T043"], "canonical_name": "negative regulation of substrate adhesion-dependent cell spreading", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269291", "aliases": ["positive regulation of cell spreading during cell substrate adhesion", "up regulation of substrate adhesion dependent cell spreading", "up regulation of substrate adhesion-dependent cell spreading", "positive regulation of substrate adhesion dependent cell spreading", "up regulation of cell spreading during cell substrate adhesion"], "types": ["T043"], "canonical_name": "positive regulation of substrate adhesion-dependent cell spreading", "definition": "Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269292", "aliases": ["regulation of membrane ruffling", "regulation of membrane ruffle formation"], "types": ["T043"], "canonical_name": "regulation of ruffle assembly", "definition": "Any process that modulates the frequency, rate or extent of ruffle assembly. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269293", "aliases": ["down regulation of membrane ruffle formation", "negative regulation of membrane ruffle formation", "negative regulation of membrane ruffling", "down regulation of membrane ruffling"], "types": ["T043"], "canonical_name": "negative regulation of ruffle assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269294", "aliases": [], "types": ["T043"], "canonical_name": "down regulation of ruffle assembly"}
{"concept_id": "C3269295", "aliases": ["up regulation of ruffle assembly", "positive regulation of membrane ruffle formation", "up regulation of membrane ruffling", "up regulation of membrane ruffle formation", "positive regulation of membrane ruffling"], "types": ["T043"], "canonical_name": "positive regulation of ruffle assembly", "definition": "Any process that activates or increases the frequency, rate or extent of ruffle assembly. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269297", "aliases": ["regulation of pectin synthesis", "regulation of pectin formation", "regulation of pectin anabolism", "regulation of pectin biosynthesis"], "types": ["T043"], "canonical_name": "regulation of pectin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of pectin biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3269308", "aliases": ["regulation of trichome pattern biosynthesis", "regulation of trichome pattern formation", "regulation of trichome spacing"], "types": ["T043"], "canonical_name": "regulation of trichome patterning", "definition": "Any process that modulates the frequency, rate or extent of trichome patterning. [GOC:TermGenie]"}
{"concept_id": "C3269309", "aliases": ["negative regulation of trichome pattern formation", "down-regulation of trichome pattern formation", "down regulation of trichome pattern formation", "downregulation of trichome spacing", "inhibition of trichome spacing", "inhibition of trichome pattern biosynthesis", "down-regulation of trichome spacing", "down-regulation of trichome pattern biosynthesis", "downregulation of trichome pattern biosynthesis", "downregulation of trichome pattern formation", "down regulation of trichome pattern biosynthesis", "negative regulation of trichome pattern biosynthesis", "negative regulation of trichome spacing", "down regulation of trichome spacing", "inhibition of trichome pattern formation"], "types": ["T043"], "canonical_name": "negative regulation of trichome patterning", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of trichome patterning. [GOC:TermGenie]"}
{"concept_id": "C3269310", "aliases": ["regulation of cellular response to heat stress"], "types": ["T043"], "canonical_name": "regulation of cellular response to heat", "definition": "Any process that modulates the frequency, rate or extent of cellular response to heat. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269311", "aliases": ["inhibition of cellular response to heat", "down regulation of cellular response to heat", "down-regulation of cellular response to heat stress", "down regulation of cellular response to heat stress", "downregulation of cellular response to heat", "negative regulation of cellular response to heat stress", "downregulation of cellular response to heat stress", "inhibition of cellular response to heat stress", "down-regulation of cellular response to heat"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to heat", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to heat. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269312", "aliases": ["activation of cellular response to heat", "up regulation of cellular response to heat stress", "upregulation of cellular response to heat stress", "positive regulation of cellular response to heat stress", "activation of cellular response to heat stress", "up-regulation of cellular response to heat stress", "upregulation of cellular response to heat"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to heat", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to heat. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269313", "aliases": ["up-regulation of cellular response to heat"], "types": ["T043"], "canonical_name": "up regulation of cellular response to heat"}
{"concept_id": "C3269314", "aliases": ["regulation of cellular response to hypoxic stress", "regulation of cellular response to lowered oxygen tension"], "types": ["T043"], "canonical_name": "regulation of cellular response to hypoxia", "definition": "Any process that modulates the frequency, rate or extent of cellular response to hypoxia. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269315", "aliases": ["down-regulation of cellular response to hypoxia"], "types": ["T043"], "canonical_name": "down regulation of cellular response to hypoxia"}
{"concept_id": "C3269317", "aliases": ["activation of cellular response to hypoxia", "up regulation of cellular response to hypoxic stress", "activation of cellular response to lowered oxygen tension", "up regulation of cellular response to lowered oxygen tension", "up-regulation of cellular response to lowered oxygen tension", "up-regulation of cellular response to hypoxic stress", "upregulation of cellular response to hypoxic stress", "positive regulation of cellular response to hypoxic stress", "upregulation of cellular response to lowered oxygen tension", "positive regulation of cellular response to lowered oxygen tension", "activation of cellular response to hypoxic stress", "upregulation of cellular response to hypoxia"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to hypoxia", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269318", "aliases": ["up-regulation of cellular response to hypoxia"], "types": ["T043"], "canonical_name": "up regulation of cellular response to hypoxia"}
{"concept_id": "C3269336", "aliases": ["regulation of protein K63-linked polyubiquitination"], "types": ["T044"], "canonical_name": "regulation of protein K63-linked ubiquitination", "definition": "Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination. [GOC:TermGenie]"}
{"concept_id": "C3269337", "aliases": ["downregulation of protein K63-linked polyubiquitination", "inhibition of protein K63-linked polyubiquitination", "down-regulation of protein K63-linked polyubiquitination", "down regulation of protein K63-linked polyubiquitination", "negative regulation of protein K63-linked polyubiquitination"], "types": ["T044"], "canonical_name": "negative regulation of protein K63-linked ubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination. [GOC:TermGenie]"}
{"concept_id": "C3269338", "aliases": ["down-regulation of protein K63-linked ubiquitination"], "types": ["T044"], "canonical_name": "down regulation of protein K63-linked ubiquitination"}
{"concept_id": "C3269339", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of protein K63-linked ubiquitination"}
{"concept_id": "C3269340", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein K63-linked ubiquitination"}
{"concept_id": "C3269341", "aliases": [], "types": ["T038"], "canonical_name": "regulation of hemostasis", "definition": "Any process that modulates the frequency, rate or extent of hemostasis. [GOC:TermGenie]"}
{"concept_id": "C3269342", "aliases": ["down-regulation of hemostasis", "down regulation of hemostasis", "downregulation of hemostasis"], "types": ["T038"], "canonical_name": "negative regulation of hemostasis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis. [GOC:TermGenie]"}
{"concept_id": "C3269343", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of hemostasis"}
{"concept_id": "C3269344", "aliases": ["upregulation of hemostasis", "up-regulation of hemostasis", "up regulation of hemostasis"], "types": ["T038"], "canonical_name": "positive regulation of hemostasis", "definition": "Any process that activates or increases the frequency, rate or extent of hemostasis. [GOC:TermGenie]"}
{"concept_id": "C3269345", "aliases": [], "types": ["T038"], "canonical_name": "activation of hemostasis"}
{"concept_id": "C3269346", "aliases": ["regulation of histone replacement", "regulation of histone displacement"], "types": ["T043"], "canonical_name": "regulation of histone exchange", "definition": "Any process that modulates the frequency, rate or extent of histone exchange. [GOC:TermGenie, PMID:20332092]"}
{"concept_id": "C3269347", "aliases": [], "types": ["T043"], "canonical_name": "regulation of histone chaperone"}
{"concept_id": "C3269348", "aliases": ["negative regulation of histone replacement", "down regulation of histone replacement", "down-regulation of histone replacement", "inhibition of histone replacement", "downregulation of histone replacement"], "types": ["T043"], "canonical_name": "negative regulation of histone exchange", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone exchange. [GOC:TermGenie, PMID:20332092]"}
{"concept_id": "C3269349", "aliases": ["down-regulation of histone chaperone"], "types": ["T043"], "canonical_name": "down regulation of histone chaperone"}
{"concept_id": "C3269350", "aliases": ["down-regulation of histone exchange"], "types": ["T043"], "canonical_name": "down regulation of histone exchange"}
{"concept_id": "C3269351", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of histone chaperone"}
{"concept_id": "C3269352", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of histone exchange"}
{"concept_id": "C3269353", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of histone chaperone"}
{"concept_id": "C3269354", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of histone exchange"}
{"concept_id": "C3269355", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of histone chaperone"}
{"concept_id": "C3269356", "aliases": ["activation of histone replacement", "upregulation of histone replacement", "activation of histone exchange", "positive regulation of histone replacement", "upregulation of histone exchange", "up-regulation of histone replacement", "up regulation of histone replacement"], "types": ["T043"], "canonical_name": "positive regulation of histone exchange", "definition": "Any process that activates or increases the frequency, rate or extent of histone exchange. [GOC:TermGenie, PMID:20332092]"}
{"concept_id": "C3269357", "aliases": ["up-regulation of histone chaperone"], "types": ["T043"], "canonical_name": "up regulation of histone chaperone"}
{"concept_id": "C3269358", "aliases": ["up-regulation of histone exchange"], "types": ["T043"], "canonical_name": "up regulation of histone exchange"}
{"concept_id": "C3269359", "aliases": ["positive regulation of histone chaperone", "upregulation of histone chaperone"], "types": ["T043"], "canonical_name": "activation of histone chaperone"}
{"concept_id": "C3269360", "aliases": ["regulation of retinoic acid anabolic process"], "types": ["T044"], "canonical_name": "regulation of retinoic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269361", "aliases": ["down-regulation of retinoic acid anabolic process", "downregulation of retinoic acid anabolic process", "down regulation of retinoic acid anabolic process", "inhibition of retinoic acid anabolic process", "negative regulation of retinoic acid anabolic process"], "types": ["T044"], "canonical_name": "negative regulation of retinoic acid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269362", "aliases": ["downregulation of retinoic acid biosynthetic process", "down-regulation of retinoic acid biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of retinoic acid biosynthetic process"}
{"concept_id": "C3269363", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of retinoic acid biosynthetic process"}
{"concept_id": "C3269364", "aliases": ["up-regulation of retinoic acid anabolic process", "positive regulation of retinoic acid anabolic process", "upregulation of retinoic acid anabolic process", "activation of retinoic acid anabolic process", "up regulation of retinoic acid anabolic process"], "types": ["T044"], "canonical_name": "positive regulation of retinoic acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269365", "aliases": [], "types": ["T044"], "canonical_name": "activation of retinoic acid biosynthetic process"}
{"concept_id": "C3269366", "aliases": ["up-regulation of retinoic acid biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of retinoic acid biosynthetic process"}
{"concept_id": "C3269367", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of retinoic acid biosynthetic process"}
{"concept_id": "C3269368", "aliases": [], "types": ["T038"], "canonical_name": "regulation of leaf senescence", "definition": "Any process that modulates the frequency, rate or extent of leaf senescence. [GOC:TermGenie]"}
{"concept_id": "C3269369", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of leaf senescence", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence. [GOC:TermGenie]"}
{"concept_id": "C3269370", "aliases": ["down-regulation of leaf senescence", "downregulation of leaf senescence"], "types": ["T038"], "canonical_name": "down regulation of leaf senescence"}
{"concept_id": "C3269371", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of leaf senescence"}
{"concept_id": "C3269372", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of leaf senescence", "definition": "Any process that activates or increases the frequency, rate or extent of leaf senescence. [GOC:TermGenie]"}
{"concept_id": "C3269373", "aliases": [], "types": ["T038"], "canonical_name": "activation of leaf senescence"}
{"concept_id": "C3269374", "aliases": ["upregulation of leaf senescence", "up-regulation of leaf senescence"], "types": ["T038"], "canonical_name": "up regulation of leaf senescence"}
{"concept_id": "C3269375", "aliases": ["regulation of sulphate assimilation"], "types": ["T044"], "canonical_name": "regulation of sulfate assimilation", "definition": "Any process that modulates the frequency, rate or extent of sulfate assimilation. [GOC:TermGenie, PMID:7601277, PMID:7891681]"}
{"concept_id": "C3269376", "aliases": ["regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor"], "types": ["T044"], "canonical_name": "regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor"}
{"concept_id": "C3269377", "aliases": ["activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor"], "types": ["T044"], "canonical_name": "activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor"}
{"concept_id": "C3269378", "aliases": ["positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor"], "types": ["T044"], "canonical_name": "positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor"}
{"concept_id": "C3269380", "aliases": ["up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor", "up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor", "up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor"], "types": ["T044"], "canonical_name": "up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor"}
{"concept_id": "C3269381", "aliases": ["upregulation of sulfate assimilation", "up regulation of sulfate assimilation", "up-regulation of sulphate assimilation", "upregulation of sulphate assimilation", "activation of sulfate assimilation", "positive regulation of sulphate assimilation", "activation of sulphate assimilation", "up-regulation of sulfate assimilation", "up regulation of sulphate assimilation"], "types": ["T044"], "canonical_name": "positive regulation of sulfate assimilation", "definition": "Any process that activates or increases the frequency, rate or extent of sulfate assimilation. [GOC:TermGenie, PMID:7601277, PMID:7891681]"}
{"concept_id": "C3269382", "aliases": ["upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor"], "types": ["T044"], "canonical_name": "upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor"}
{"concept_id": "C3269383", "aliases": ["down-regulation of ceramide anabolism", "down regulation of ceramide biosynthesis", "down-regulation of ceramide synthesis", "negative regulation of ceramide anabolism", "down regulation of ceramide synthesis", "downregulation of ceramide biosynthesis", "down regulation of ceramide formation", "negative regulation of ceramide formation", "inhibition of ceramide synthesis", "downregulation of ceramide formation", "inhibition of ceramide formation", "negative regulation of ceramide synthesis", "inhibition of ceramide biosynthesis", "downregulation of ceramide anabolism", "down regulation of ceramide anabolism", "inhibition of ceramide anabolism", "down-regulation of ceramide formation", "down-regulation of ceramide biosynthesis", "downregulation of ceramide synthesis", "negative regulation of ceramide biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of ceramide biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process. [GOC:TermGenie, PMID:15302821]"}
{"concept_id": "C3269384", "aliases": ["down-regulation of ceramide biosynthetic process", "downregulation of ceramide biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of ceramide biosynthetic process"}
{"concept_id": "C3269385", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ceramide biosynthetic process"}
{"concept_id": "C3269388", "aliases": [], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter by calcium-mediated signaling"}
{"concept_id": "C3269393", "aliases": [], "types": ["T045"], "canonical_name": "spliceosomal complex assembly", "definition": "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. [PMID:9476892]"}
{"concept_id": "C3269396", "aliases": ["EGF breakdown", "EGF catabolism", "epidermal growth factor catabolism", "epidermal growth factor breakdown"], "types": ["T044"], "canonical_name": "epidermal growth factor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor. [GOC:bf, GOC:signaling, PMID:2985587]"}
{"concept_id": "C3269397", "aliases": [], "types": ["T044"], "canonical_name": "intracellular EGF processing"}
{"concept_id": "C3269398", "aliases": [], "types": ["T044"], "canonical_name": "receptor-mediated EGF processing"}
{"concept_id": "C3269400", "aliases": [], "types": ["T044"], "canonical_name": "p50-dependent NF-kappaB signaling"}
{"concept_id": "C3269402", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of NF-kappaB-inducing kinase activity"}
{"concept_id": "C3269405", "aliases": ["dpp signaling pathway"], "types": ["T044"], "canonical_name": "decapentaplegic signaling pathway"}
{"concept_id": "C3269406", "aliases": ["DNA bending involving DNA binding", "DNA bending activity"], "types": ["T044"], "canonical_name": "DNA binding, bending", "definition": "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]"}
{"concept_id": "C3269409", "aliases": [], "types": ["T042"], "canonical_name": "chaeta morphogenesis", "definition": "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell. [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]"}
{"concept_id": "C3269410", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine transporter activity", "definition": "Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C3269411", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase"}
{"concept_id": "C3269412", "aliases": [], "types": ["T044"], "canonical_name": "activation of caspase activity by cytochrome c"}
{"concept_id": "C3269413", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type endopeptidase activator activity involved in apoptotic process", "definition": "Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process. [GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C3269415", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling"}
{"concept_id": "C3269417", "aliases": ["positive regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling", "upregulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling"], "types": ["T045"], "canonical_name": "positive regulation of global transcription from Pol II promoter by calcium-mediated signaling"}
{"concept_id": "C3269420", "aliases": ["stimulation of transcription from RNA polymerase II promoter by calcium-mediated signaling", "positive regulation of transcription from Pol II promoter by calcium-mediated signaling", "up regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling", "upregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling", "up-regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling", "activation of transcription from RNA polymerase II promoter by calcium-mediated signaling"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling", "definition": "Calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter. [GOC:bf, GOC:BHF, GOC:dgf, GOC:TermGenie, PMID:9407035, PMID:9407036]"}
{"concept_id": "C3269422", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling"}
{"concept_id": "C3269425", "aliases": ["up-regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling"], "types": ["T045"], "canonical_name": "up regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling"}
{"concept_id": "C3269430", "aliases": ["regulation of peroxisome organisation"], "types": ["T043"], "canonical_name": "regulation of peroxisome organization", "definition": "Any process that modulates the frequency, rate or extent of peroxisome organization. [GOC:TermGenie, PMID:7500953]"}
{"concept_id": "C3269431", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peroxisome organization and biogenesis"}
{"concept_id": "C3269432", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peroxisome-assembly ATPase activity"}
{"concept_id": "C3269433", "aliases": ["upregulation of peroxisome organisation", "upregulation of peroxisome organization", "up-regulation of peroxisome organisation", "positive regulation of peroxisome organisation", "up regulation of peroxisome organisation", "up-regulation of peroxisome organization", "up regulation of peroxisome organization"], "types": ["T043"], "canonical_name": "positive regulation of peroxisome organization", "definition": "Any process that activates or increases the frequency, rate or extent of peroxisome organization. [GOC:TermGenie, PMID:7500953]"}
{"concept_id": "C3269434", "aliases": ["activation of peroxisome organization"], "types": ["T043"], "canonical_name": "activation of peroxisome organisation"}
{"concept_id": "C3269435", "aliases": ["positive regulation of peroxisome organization and biogenesis", "upregulation of peroxisome organization and biogenesis"], "types": ["T043"], "canonical_name": "activation of peroxisome organization and biogenesis"}
{"concept_id": "C3269436", "aliases": ["upregulation of peroxisome-assembly ATPase activity", "positive regulation of peroxisome-assembly ATPase activity"], "types": ["T043"], "canonical_name": "activation of peroxisome-assembly ATPase activity"}
{"concept_id": "C3269438", "aliases": ["up-regulation of peroxisome organization and biogenesis"], "types": ["T043"], "canonical_name": "up regulation of peroxisome organization and biogenesis"}
{"concept_id": "C3269439", "aliases": ["up-regulation of peroxisome-assembly ATPase activity"], "types": ["T043"], "canonical_name": "up regulation of peroxisome-assembly ATPase activity"}
{"concept_id": "C3269440", "aliases": ["regulation of ethanol catabolism", "regulation of ethanol degradation", "regulation of ethanol breakdown"], "types": ["T044"], "canonical_name": "regulation of ethanol catabolic process", "definition": "Any process that modulates the frequency, rate or extent of ethanol catabolic process. [GOC:TermGenie, PMID:10608811, PMID:7760841]"}
{"concept_id": "C3269441", "aliases": ["up-regulation of ethanol breakdown", "up regulation of ethanol catabolism", "upregulation of ethanol catabolism", "positive regulation of ethanol breakdown", "positive regulation of ethanol catabolism", "positive regulation of ethanol degradation", "upregulation of ethanol degradation", "up-regulation of ethanol catabolism", "upregulation of ethanol breakdown", "up-regulation of ethanol degradation", "up regulation of ethanol degradation", "up regulation of ethanol breakdown"], "types": ["T044"], "canonical_name": "positive regulation of ethanol catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of ethanol catabolic process. [GOC:TermGenie, PMID:10608811, PMID:7760841]"}
{"concept_id": "C3269442", "aliases": ["activation of ethanol catabolism"], "types": ["T044"], "canonical_name": "activation of ethanol catabolic process"}
{"concept_id": "C3269443", "aliases": ["activation of ethanol degradation"], "types": ["T044"], "canonical_name": "activation of ethanol breakdown"}
{"concept_id": "C3269444", "aliases": ["up-regulation of ethanol catabolic process"], "types": ["T044"], "canonical_name": "up regulation of ethanol catabolic process"}
{"concept_id": "C3269445", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of ethanol catabolic process"}
{"concept_id": "C3269446", "aliases": ["regulation of cellular response to basic pH", "regulation of cellular response to alkalinity"], "types": ["T043"], "canonical_name": "regulation of cellular response to alkaline pH", "definition": "Any process that modulates the frequency, rate or extent of cellular response to alkalinity. [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]"}
{"concept_id": "C3269447", "aliases": ["down-regulation of cellular response to alkalinity"], "types": ["T043"], "canonical_name": "down regulation of cellular response to alkalinity"}
{"concept_id": "C3269449", "aliases": ["regulation of cellular response to hyperosmotic salt stress"], "types": ["T043"], "canonical_name": "regulation of cellular hyperosmotic salinity response", "definition": "Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response. [GOC:dgf, GOC:TermGenie, PMID:16278455]"}
{"concept_id": "C3269450", "aliases": ["down-regulation of cellular response to hyperosmotic salt stress", "down regulation of cellular response to hyperosmotic salt stress", "downregulation of cellular response to hyperosmotic salt stress", "negative regulation of cellular response to hyperosmotic salt stress"], "types": ["T043"], "canonical_name": "negative regulation of cellular hyperosmotic salinity response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response. [GOC:dgf, GOC:TermGenie, PMID:16278455]"}
{"concept_id": "C3269451", "aliases": ["down-regulation of cellular hyperosmotic salinity response"], "types": ["T043"], "canonical_name": "down regulation of cellular hyperosmotic salinity response"}
{"concept_id": "C3269452", "aliases": ["regulation of sulphite transport"], "types": ["T043"], "canonical_name": "regulation of sulfite transport", "definition": "Any process that modulates the frequency, rate or extent of sulfite transport. [GOC:TermGenie, PMID:10234785, PMID:10870099]"}
{"concept_id": "C3269453", "aliases": ["up regulation of sulfite transport", "up-regulation of sulphite transport", "upregulation of sulfite transport", "up regulation of sulphite transport", "positive regulation of sulphite transport", "up-regulation of sulfite transport", "upregulation of sulphite transport"], "types": ["T043"], "canonical_name": "positive regulation of sulfite transport", "definition": "Any process that activates or increases the frequency, rate or extent of sulfite transport. [GOC:TermGenie, PMID:10234785, PMID:10870099]"}
{"concept_id": "C3269454", "aliases": ["activation of sulphite transport"], "types": ["T043"], "canonical_name": "activation of sulfite transport"}
{"concept_id": "C3269457", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neuromuscular synaptic transmission", "definition": "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3269458", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of neuromuscular synaptic transmission", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3269459", "aliases": ["down-regulation of neuromuscular synaptic transmission"], "types": ["T042"], "canonical_name": "down regulation of neuromuscular synaptic transmission"}
{"concept_id": "C3269460", "aliases": [], "types": ["T042"], "canonical_name": "downregulation of neuromuscular synaptic transmission"}
{"concept_id": "C3269461", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of neuromuscular synaptic transmission"}
{"concept_id": "C3269462", "aliases": ["up-regulation of neuromuscular synaptic transmission", "up regulation of neuromuscular synaptic transmission", "activation of neuromuscular synaptic transmission", "upregulation of neuromuscular synaptic transmission"], "types": ["T042"], "canonical_name": "positive regulation of neuromuscular synaptic transmission", "definition": "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3269463", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to insulin stimulus", "definition": "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269464", "aliases": ["down regulation of cellular response to insulin stimulus", "downregulation of cellular response to insulin stimulus", "down-regulation of cellular response to insulin stimulus"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to insulin stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269465", "aliases": ["upregulation of cellular response to insulin stimulus", "up-regulation of cellular response to insulin stimulus", "up regulation of cellular response to insulin stimulus", "activation of cellular response to insulin stimulus"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to insulin stimulus", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269466", "aliases": ["regulation of arginine formation", "regulation of arginine synthesis", "regulation of arginine biosynthesis", "regulation of arginine anabolism"], "types": ["T044"], "canonical_name": "regulation of arginine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of arginine biosynthetic process. [GOC:dgf, GOC:TermGenie]"}
{"concept_id": "C3269467", "aliases": ["activation of arginine biosynthetic process", "activation of arginine formation", "activation of arginine biosynthesis", "activation of arginine synthesis"], "types": ["T044"], "canonical_name": "activation of arginine anabolism"}
{"concept_id": "C3269468", "aliases": ["regulation of arginine breakdown", "regulation of arginine degradation", "regulation of arginine catabolism"], "types": ["T044"], "canonical_name": "regulation of arginine catabolic process", "definition": "Any process that modulates the frequency, rate or extent of arginine catabolic process. [GOC:dgf, GOC:TermGenie]"}
{"concept_id": "C3269469", "aliases": ["down regulation of arginine catabolic process", "downregulation of arginine catabolic process", "down-regulation of arginine catabolism", "negative regulation of arginine degradation", "negative regulation of arginine breakdown", "downregulation of arginine degradation", "down-regulation of arginine catabolic process", "negative regulation of arginine catabolism", "downregulation of arginine catabolism", "down regulation of arginine breakdown", "down regulation of arginine catabolism", "down-regulation of arginine degradation", "down regulation of arginine degradation", "downregulation of arginine breakdown", "down-regulation of arginine breakdown"], "types": ["T040"], "canonical_name": "negative regulation of arginine catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process. [GOC:dgf, GOC:TermGenie]"}
{"concept_id": "C3269470", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of arginine breakdown"}
{"concept_id": "C3269471", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of arginine catabolic process"}
{"concept_id": "C3269472", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of arginine catabolism"}
{"concept_id": "C3269473", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of arginine degradation"}
{"concept_id": "C3269475", "aliases": ["regulation of tyrosine autophosphorylation"], "types": ["T044"], "canonical_name": "regulation of peptidyl-tyrosine autophosphorylation", "definition": "Any process that modulates the frequency, rate or extent of peptidyl-tyrosine autophosphorylation. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3269476", "aliases": [], "types": ["T044"], "canonical_name": "regulation of receptor tyrosine kinase autophosphorylation"}
{"concept_id": "C3269477", "aliases": ["downregulation of tyrosine autophosphorylation", "negative regulation of tyrosine autophosphorylation", "down regulation of tyrosine autophosphorylation", "down-regulation of peptidyl-tyrosine autophosphorylation", "downregulation of peptidyl-tyrosine autophosphorylation", "down-regulation of tyrosine autophosphorylation", "down regulation of peptidyl-tyrosine autophosphorylation"], "types": ["T044"], "canonical_name": "negative regulation of peptidyl-tyrosine autophosphorylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3269478", "aliases": ["down-regulation of receptor tyrosine kinase autophosphorylation"], "types": ["T044"], "canonical_name": "down regulation of receptor tyrosine kinase autophosphorylation"}
{"concept_id": "C3269479", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of receptor tyrosine kinase autophosphorylation"}
{"concept_id": "C3269480", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptidyl-tyrosine autophosphorylation"}
{"concept_id": "C3269481", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of receptor tyrosine kinase autophosphorylation"}
{"concept_id": "C3269482", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tyrosine autophosphorylation"}
{"concept_id": "C3269483", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of receptor tyrosine kinase autophosphorylation"}
{"concept_id": "C3269484", "aliases": ["upregulation of peptidyl-tyrosine autophosphorylation", "up-regulation of peptidyl-tyrosine autophosphorylation", "up-regulation of tyrosine autophosphorylation", "positive regulation of tyrosine autophosphorylation", "up regulation of tyrosine autophosphorylation", "upregulation of tyrosine autophosphorylation", "up regulation of peptidyl-tyrosine autophosphorylation"], "types": ["T044"], "canonical_name": "positive regulation of peptidyl-tyrosine autophosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3269485", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptidyl-tyrosine autophosphorylation"}
{"concept_id": "C3269487", "aliases": ["positive regulation of receptor tyrosine kinase autophosphorylation", "upregulation of receptor tyrosine kinase autophosphorylation", "up-regulation of receptor tyrosine kinase autophosphorylation", "up regulation of receptor tyrosine kinase autophosphorylation"], "types": ["T044"], "canonical_name": "activation of receptor tyrosine kinase autophosphorylation"}
{"concept_id": "C3269488", "aliases": ["up regulation of G1/S transition of mitotic cell cycle", "up-regulation of G1/S transition of mitotic cell cycle", "upregulation of G1/S transition of mitotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of G1/S transition of mitotic cell cycle", "definition": "Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3269489", "aliases": [], "types": ["T043"], "canonical_name": "activation of G1/S transition of mitotic cell cycle"}
{"concept_id": "C3269490", "aliases": ["regulation of vitamin Bh biosynthesis", "regulation of inositol biosynthesis", "regulation of inositol anabolism", "regulation of vitamin Bh biosynthetic process", "regulation of inositol synthesis", "regulation of inositol formation"], "types": ["T043"], "canonical_name": "regulation of inositol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of inositol biosynthetic process. [GOC:TermGenie, PMID:22307851]"}
{"concept_id": "C3269491", "aliases": ["regulation of myo-inositol biosynthetic process"], "types": ["T043"], "canonical_name": "regulation of myo-inositol biosynthesis"}
{"concept_id": "C3269492", "aliases": ["negative regulation of vitamin Bh biosynthesis", "down regulation of inositol synthesis", "negative regulation of inositol formation", "inhibition of inositol biosynthesis", "negative regulation of inositol anabolism", "down regulation of vitamin Bh biosynthetic process", "down-regulation of inositol anabolism", "inhibition of vitamin Bh biosynthetic process", "down regulation of inositol biosynthetic process", "negative regulation of vitamin Bh biosynthetic process", "downregulation of inositol anabolism", "down regulation of inositol biosynthesis", "inhibition of inositol anabolism", "negative regulation of inositol synthesis", "down-regulation of inositol biosynthetic process", "downregulation of vitamin Bh biosynthetic process", "inhibition of inositol formation", "inhibition of vitamin Bh biosynthesis", "down-regulation of inositol formation", "down-regulation of vitamin Bh biosynthesis", "negative regulation of inositol biosynthesis", "inhibition of inositol synthesis", "down-regulation of inositol biosynthesis", "down regulation of inositol formation", "downregulation of inositol formation", "down-regulation of inositol synthesis", "downregulation of inositol biosynthesis", "downregulation of inositol synthesis", "downregulation of vitamin Bh biosynthesis", "down-regulation of vitamin Bh biosynthetic process", "down regulation of inositol anabolism", "downregulation of inositol biosynthetic process", "down regulation of vitamin Bh biosynthesis"], "types": ["T043"], "canonical_name": "negative regulation of inositol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of inositol biosynthetic process. [GOC:TermGenie, PMID:22307851]"}
{"concept_id": "C3269493", "aliases": ["down-regulation of myo-inositol biosynthesis"], "types": ["T043"], "canonical_name": "down regulation of myo-inositol biosynthesis"}
{"concept_id": "C3269494", "aliases": ["down-regulation of myo-inositol biosynthetic process"], "types": ["T043"], "canonical_name": "down regulation of myo-inositol biosynthetic process"}
{"concept_id": "C3269495", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of myo-inositol biosynthesis"}
{"concept_id": "C3269496", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of myo-inositol biosynthetic process"}
{"concept_id": "C3269497", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of inositol biosynthetic process"}
{"concept_id": "C3269498", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myo-inositol biosynthesis"}
{"concept_id": "C3269499", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myo-inositol biosynthetic process"}
{"concept_id": "C3269500", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myo-inositol biosynthesis"}
{"concept_id": "C3269501", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myo-inositol biosynthetic process"}
{"concept_id": "C3269502", "aliases": ["up regulation of vitamin Bh biosynthesis", "upregulation of vitamin Bh biosynthetic process", "positive regulation of inositol biosynthesis", "activation of inositol synthesis", "upregulation of inositol anabolism", "upregulation of inositol formation", "up regulation of inositol anabolism", "up-regulation of inositol anabolism", "up regulation of inositol synthesis", "up regulation of vitamin Bh biosynthetic process", "positive regulation of inositol synthesis", "upregulation of inositol synthesis", "up-regulation of vitamin Bh biosynthesis", "activation of vitamin Bh biosynthesis", "upregulation of inositol biosynthesis", "up-regulation of inositol biosynthetic process", "positive regulation of vitamin Bh biosynthesis", "positive regulation of vitamin Bh biosynthetic process", "up-regulation of vitamin Bh biosynthetic process", "positive regulation of inositol anabolism", "up regulation of inositol formation", "positive regulation of inositol formation", "up regulation of inositol biosynthesis", "activation of inositol biosynthesis", "up-regulation of inositol biosynthesis", "upregulation of vitamin Bh biosynthesis", "activation of inositol anabolism", "upregulation of inositol biosynthetic process", "activation of vitamin Bh biosynthetic process", "up regulation of inositol biosynthetic process", "activation of inositol formation", "up-regulation of inositol synthesis", "up-regulation of inositol formation"], "types": ["T044"], "canonical_name": "positive regulation of inositol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of inositol biosynthetic process. [GOC:TermGenie, PMID:22307851]"}
{"concept_id": "C3269503", "aliases": [], "types": ["T044"], "canonical_name": "activation of inositol biosynthetic process"}
{"concept_id": "C3269504", "aliases": ["activation of myo-inositol biosynthetic process"], "types": ["T044"], "canonical_name": "activation of myo-inositol biosynthesis"}
{"concept_id": "C3269505", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of myo-inositol biosynthesis"}
{"concept_id": "C3269506", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of myo-inositol biosynthetic process"}
{"concept_id": "C3269507", "aliases": ["up-regulation of myo-inositol biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of myo-inositol biosynthesis"}
{"concept_id": "C3269508", "aliases": ["up-regulation of myo-inositol biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of myo-inositol biosynthetic process"}
{"concept_id": "C3269509", "aliases": ["upregulation of myo-inositol biosynthetic process"], "types": ["T044"], "canonical_name": "upregulation of myo-inositol biosynthesis"}
{"concept_id": "C3269510", "aliases": ["regulation of raffinose biosynthesis", "regulation of raffinose formation", "regulation of raffinose anabolism", "regulation of raffinose synthesis"], "types": ["T043"], "canonical_name": "regulation of raffinose biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of raffinose biosynthetic process. [GOC:TermGenie, PMID:22307851]"}
{"concept_id": "C3269511", "aliases": ["downregulation of raffinose formation", "negative regulation of raffinose formation", "inhibition of raffinose biosynthesis", "inhibition of raffinose anabolism", "inhibition of raffinose synthesis", "inhibition of raffinose formation", "downregulation of raffinose biosynthetic process", "downregulation of raffinose synthesis", "down regulation of raffinose biosynthetic process", "negative regulation of raffinose anabolism", "down regulation of raffinose anabolism", "down-regulation of raffinose biosynthetic process", "negative regulation of raffinose biosynthesis", "negative regulation of raffinose synthesis", "down-regulation of raffinose biosynthesis", "down regulation of raffinose biosynthesis", "down-regulation of raffinose formation", "down regulation of raffinose formation", "down regulation of raffinose synthesis", "down-regulation of raffinose synthesis", "downregulation of raffinose biosynthesis", "down-regulation of raffinose anabolism", "downregulation of raffinose anabolism"], "types": ["T044"], "canonical_name": "negative regulation of raffinose biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of raffinose biosynthetic process. [GOC:TermGenie, PMID:22307851]"}
{"concept_id": "C3269512", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of raffinose biosynthetic process"}
{"concept_id": "C3269513", "aliases": ["up regulation of raffinose biosynthesis", "upregulation of raffinose synthesis", "activation of raffinose anabolism", "activation of raffinose synthesis", "upregulation of raffinose anabolism", "up-regulation of raffinose synthesis", "activation of raffinose biosynthesis", "up-regulation of raffinose anabolism", "positive regulation of raffinose synthesis", "up-regulation of raffinose biosynthetic process", "positive regulation of raffinose anabolism", "upregulation of raffinose formation", "up regulation of raffinose anabolism", "upregulation of raffinose biosynthesis", "upregulation of raffinose biosynthetic process", "up-regulation of raffinose biosynthesis", "positive regulation of raffinose biosynthesis", "positive regulation of raffinose formation", "up-regulation of raffinose formation", "activation of raffinose formation", "up regulation of raffinose biosynthetic process", "up regulation of raffinose synthesis", "up regulation of raffinose formation"], "types": ["T044"], "canonical_name": "positive regulation of raffinose biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of raffinose biosynthetic process. [GOC:TermGenie, PMID:22307851]"}
{"concept_id": "C3269514", "aliases": [], "types": ["T044"], "canonical_name": "activation of raffinose biosynthetic process"}
{"concept_id": "C3269522", "aliases": ["regulation of X chromosome inactivation"], "types": ["T038"], "canonical_name": "regulation of dosage compensation by inactivation of X chromosome", "definition": "Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome. [GOC:mr, GOC:TermGenie, PMID:20622855, Wikipedia:XY_sex-determination_system]"}
{"concept_id": "C3269523", "aliases": [], "types": ["T038"], "canonical_name": "regulation of Barr body formation"}
{"concept_id": "C3269524", "aliases": [], "types": ["T038"], "canonical_name": "regulation of chromosome inactivation"}
{"concept_id": "C3269526", "aliases": ["down-regulation of Barr body formation", "downregulation of Barr body formation"], "types": ["T043"], "canonical_name": "down regulation of Barr body formation"}
{"concept_id": "C3269527", "aliases": ["downregulation of chromosome inactivation", "down-regulation of chromosome inactivation"], "types": ["T043"], "canonical_name": "down regulation of chromosome inactivation"}
{"concept_id": "C3269528", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Barr body formation"}
{"concept_id": "C3269529", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chromosome inactivation"}
{"concept_id": "C3269531", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Barr body formation"}
{"concept_id": "C3269532", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of chromosome inactivation"}
{"concept_id": "C3269533", "aliases": ["up regulation of X chromosome inactivation", "upregulation of dosage compensation, by inactivation of X chromosome", "positive regulation of X chromosome inactivation", "up-regulation of dosage compensation, by inactivation of X chromosome", "upregulation of X chromosome inactivation", "up-regulation of X chromosome inactivation", "activation of X chromosome inactivation", "up regulation of dosage compensation, by inactivation of X chromosome"], "types": ["T038"], "canonical_name": "positive regulation of dosage compensation by inactivation of X chromosome", "definition": "Any process that activates or increases the frequency, rate or extent of dosage compensation, by inactivation of X chromosome. [GOC:TermGenie]"}
{"concept_id": "C3269534", "aliases": [], "types": ["T038"], "canonical_name": "activation of Barr body formation"}
{"concept_id": "C3269535", "aliases": [], "types": ["T038"], "canonical_name": "activation of chromosome inactivation"}
{"concept_id": "C3269536", "aliases": [], "types": ["T038"], "canonical_name": "activation of dosage compensation, by inactivation of X chromosome"}
{"concept_id": "C3269537", "aliases": ["up-regulation of Barr body formation", "upregulation of Barr body formation", "up regulation of Barr body formation"], "types": ["T038"], "canonical_name": "positive regulation of Barr body formation"}
{"concept_id": "C3269538", "aliases": ["upregulation of chromosome inactivation", "up-regulation of chromosome inactivation", "up regulation of chromosome inactivation"], "types": ["T038"], "canonical_name": "positive regulation of chromosome inactivation"}
{"concept_id": "C3269539", "aliases": [], "types": ["T038"], "canonical_name": "regulation of plasma cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of plasma cell differentiation. [GOC:TermGenie]"}
{"concept_id": "C3269540", "aliases": ["downregulation of plasma cell development", "down-regulation of plasma cell development"], "types": ["T043"], "canonical_name": "down regulation of plasma cell development"}
{"concept_id": "C3269541", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of plasma cell development"}
{"concept_id": "C3269542", "aliases": ["down-regulation of plasma cell differentiation", "down regulation of plasma cell differentiation", "downregulation of plasma cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of plasma cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation. [GOC:TermGenie]"}
{"concept_id": "C3269543", "aliases": [], "types": ["T038"], "canonical_name": "activation of plasma cell differentiation"}
{"concept_id": "C3269544", "aliases": ["upregulation of plasma cell differentiation", "up-regulation of plasma cell differentiation", "up regulation of plasma cell differentiation"], "types": ["T038"], "canonical_name": "positive regulation of plasma cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of plasma cell differentiation. [GOC:TermGenie]"}
{"concept_id": "C3269545", "aliases": ["upregulation of plasma cell development", "up-regulation of plasma cell development"], "types": ["T038"], "canonical_name": "up regulation of plasma cell development"}
{"concept_id": "C3269546", "aliases": ["regulation of erUPR", "regulation of ER unfolded protein response"], "types": ["T044"], "canonical_name": "regulation of endoplasmic reticulum unfolded protein response", "definition": "Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response. [GOC:TermGenie]"}
{"concept_id": "C3269547", "aliases": ["down regulation of ER unfolded protein response", "negative regulation of erUPR", "downregulation of endoplasmic reticulum unfolded protein response", "inhibition of erUPR", "down regulation of erUPR", "inhibition of ER unfolded protein response", "down-regulation of erUPR", "negative regulation of ER unfolded protein response", "downregulation of erUPR", "down-regulation of endoplasmic reticulum unfolded protein response", "down-regulation of ER unfolded protein response", "downregulation of ER unfolded protein response", "down regulation of endoplasmic reticulum unfolded protein response"], "types": ["T044"], "canonical_name": "negative regulation of endoplasmic reticulum unfolded protein response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response. [GOC:TermGenie]"}
{"concept_id": "C3269548", "aliases": ["down-regulation of SREBP-mediated signalling pathway"], "types": ["T044"], "canonical_name": "down regulation of SREBP-mediated signalling pathway"}
{"concept_id": "C3269549", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of SREBP-mediated signalling pathway"}
{"concept_id": "C3269550", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of endoplasmic reticulum unfolded protein response"}
{"concept_id": "C3269551", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of SREBP-mediated signalling pathway"}
{"concept_id": "C3269554", "aliases": [], "types": ["T044"], "canonical_name": "activation of SREBP-mediated signalling pathway"}
{"concept_id": "C3269555", "aliases": ["up-regulation of SREBP-mediated signalling pathway"], "types": ["T044"], "canonical_name": "up regulation of SREBP-mediated signalling pathway"}
{"concept_id": "C3269556", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of SREBP-mediated signalling pathway"}
{"concept_id": "C3269557", "aliases": ["regulation of HA cable assembly"], "types": ["T043"], "canonical_name": "regulation of hyaluranon cable assembly", "definition": "Any process that modulates the frequency, rate or extent of hyaluranon cable assembly. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269558", "aliases": ["downregulation of hyaluranon cable assembly", "down regulation of hyaluranon cable assembly", "downregulation of HA cable assembly", "negative regulation of HA cable assembly", "down regulation of HA cable assembly", "inhibition of HA cable assembly", "down-regulation of hyaluranon cable assembly", "down-regulation of HA cable assembly"], "types": ["T043"], "canonical_name": "negative regulation of hyaluranon cable assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluranon cable assembly. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269559", "aliases": ["upregulation of HA cable assembly", "positive regulation of HA cable assembly", "activation of hyaluranon cable assembly", "upregulation of hyaluranon cable assembly", "up regulation of hyaluranon cable assembly", "up-regulation of hyaluranon cable assembly", "up-regulation of HA cable assembly", "activation of HA cable assembly", "up regulation of HA cable assembly"], "types": ["T043"], "canonical_name": "positive regulation of hyaluranon cable assembly", "definition": "Any process that activates or increases the frequency, rate or extent of hyaluranon cable assembly. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269560", "aliases": ["regulation of nodal signaling", "regulation of nodal signalling pathway"], "types": ["T043"], "canonical_name": "regulation of nodal signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of nodal signaling pathway. [GOC:BHF, GOC:TermGenie, GOC:vk]"}
{"concept_id": "C3269561", "aliases": ["negative regulation of nodal signaling", "downregulation of nodal signaling pathway", "down regulation of nodal signaling pathway", "downregulation of nodal signaling", "negative regulation of nodal signalling pathway", "down regulation of nodal signaling", "down-regulation of nodal signaling pathway", "down-regulation of nodal signaling"], "types": ["T043"], "canonical_name": "negative regulation of nodal signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway. [GOC:BHF, GOC:TermGenie, GOC:vk]"}
{"concept_id": "C3269562", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nodal signaling"}
{"concept_id": "C3269563", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nodal signaling pathway"}
{"concept_id": "C3269564", "aliases": ["regulation of histone lysine H3 K9 dimethylation", "regulation of histone H3 K9 dimethylation"], "types": ["T044"], "canonical_name": "regulation of histone H3-K9 dimethylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K9 dimethylation. [GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3269565", "aliases": ["downregulation of histone H3 K9 dimethylation", "down-regulation of histone H3 K9 dimethylation", "down regulation of histone lysine H3 K9 dimethylation", "down regulation of histone H3-K9 dimethylation", "negative regulation of histone H3 K9 dimethylation", "down-regulation of histone H3-K9 dimethylation", "negative regulation of histone lysine H3 K9 dimethylation", "down regulation of histone H3 K9 dimethylation", "downregulation of histone H3-K9 dimethylation", "downregulation of histone lysine H3 K9 dimethylation", "down-regulation of histone lysine H3 K9 dimethylation"], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K9 dimethylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 dimethylation. [GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3269566", "aliases": ["inhibition of histone H3-K9 dimethylation"], "types": ["T044"], "canonical_name": "inhibition of histone H3 K9 dimethylation"}
{"concept_id": "C3269567", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone lysine H3 K9 dimethylation"}
{"concept_id": "C3269568", "aliases": ["up regulation of histone lysine H3 K9 dimethylation", "up-regulation of histone lysine H3 K9 dimethylation", "up-regulation of histone H3-K9 dimethylation", "up regulation of histone H3-K9 dimethylation", "upregulation of histone H3-K9 dimethylation", "up-regulation of histone H3 K9 dimethylation", "upregulation of histone H3 K9 dimethylation", "up regulation of histone H3 K9 dimethylation", "positive regulation of histone H3 K9 dimethylation", "positive regulation of histone lysine H3 K9 dimethylation", "upregulation of histone lysine H3 K9 dimethylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K9 dimethylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K9 dimethylation. [GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3269569", "aliases": ["activation of histone H3-K9 dimethylation"], "types": ["T044"], "canonical_name": "activation of histone H3 K9 dimethylation"}
{"concept_id": "C3269570", "aliases": [], "types": ["T044"], "canonical_name": "activation of histone lysine H3 K9 dimethylation"}
{"concept_id": "C3269571", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H3-K9 trimethylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation. [GOC:TermGenie]"}
{"concept_id": "C3269572", "aliases": ["down-regulation of histone H3-K9 trimethylation", "down regulation of histone H3-K9 trimethylation", "downregulation of histone H3-K9 trimethylation"], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K9 trimethylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 trimethylation. [GOC:TermGenie]"}
{"concept_id": "C3269573", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H3-K9 trimethylation"}
{"concept_id": "C3269574", "aliases": ["up-regulation of histone H3-K9 trimethylation", "up regulation of histone H3-K9 trimethylation", "upregulation of histone H3-K9 trimethylation", "activation of histone H3-K9 trimethylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K9 trimethylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation. [GOC:TermGenie]"}
{"concept_id": "C3269575", "aliases": ["regulation of signalling pathway in extracellular region", "regulation of signaling pathway in extracellular region"], "types": ["T044"], "canonical_name": "extracellular regulation of signal transduction", "definition": "Any regulation of signal transduction that takes place in the extracellular region. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3269576", "aliases": ["negative regulation of signalling pathway in extracellular region", "downregulation of signal transduction in extracellular region", "negative regulation of signaling pathway in extracellular region", "down regulation of signal transduction in extracellular region", "down-regulation of signal transduction in extracellular region"], "types": ["T044"], "canonical_name": "extracellular negative regulation of signal transduction", "definition": "Any negative regulation of signal transduction that takes place in extracellular region. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3269577", "aliases": [], "types": ["T044"], "canonical_name": "extracellular inhibition of signaling pathway"}
{"concept_id": "C3269578", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of signal transduction in extracellular region"}
{"concept_id": "C3269579", "aliases": [], "types": ["T043"], "canonical_name": "regulation of execution phase of apoptosis", "definition": "Any process that modulates the frequency, rate or extent of execution phase of apoptosis. [GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3269580", "aliases": ["down-regulation of execution phase of apoptosis", "down regulation of execution phase of apoptosis", "downregulation of execution phase of apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of execution phase of apoptosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. [GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3269581", "aliases": ["up-regulation of execution phase of apoptosis", "up regulation of execution phase of apoptosis", "upregulation of execution phase of apoptosis", "activation of execution phase of apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of execution phase of apoptosis", "definition": "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. [GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3269582", "aliases": [], "types": ["T044"], "canonical_name": "regulation of receptor binding", "definition": "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3269583", "aliases": [], "types": ["T044"], "canonical_name": "regulation of receptor ligand"}
{"concept_id": "C3269585", "aliases": [], "types": ["T044"], "canonical_name": "down regulation of receptor-associated protein activity"}
{"concept_id": "C3269586", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of receptor binding"}
{"concept_id": "C3269587", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of receptor ligand"}
{"concept_id": "C3269589", "aliases": [], "types": ["T044"], "canonical_name": "activation of receptor binding"}
{"concept_id": "C3269590", "aliases": ["regulation of ActRIIB.ALK4.EGF-CFC complex formation", "regulation of nodal receptor complex formation"], "types": ["T043"], "canonical_name": "regulation of nodal receptor complex assembly", "definition": "Any process that modulates the frequency, rate or extent of nodal receptor complex assembly. [GOC:signaling, GOC:TermGenie, PMID:15062104]"}
{"concept_id": "C3269591", "aliases": ["down regulation of nodal receptor complex assembly", "down-regulation of ActRIIB.ALK4.EGF-CFC complex formation", "negative regulation of nodal receptor complex formation", "downregulation of ActRIIB.ALK4.EGF-CFC complex formation", "down regulation of nodal receptor complex formation", "downregulation of nodal receptor complex formation", "downregulation of nodal receptor complex assembly", "negative regulation of ActRIIB.ALK4.EGF-CFC complex formation", "down regulation of ActRIIB.ALK4.EGF-CFC complex formation", "down-regulation of nodal receptor complex assembly", "down-regulation of nodal receptor complex formation"], "types": ["T043"], "canonical_name": "negative regulation of nodal receptor complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nodal receptor complex assembly. [GOC:signaling, GOC:TermGenie, PMID:15062104]"}
{"concept_id": "C3269592", "aliases": ["regulation of hyaluronan synthesis", "regulation of hyaluronan biosynthesis", "regulation of hyaluronan anabolism", "regulation of hyaluronan formation"], "types": ["T043"], "canonical_name": "regulation of hyaluronan biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269593", "aliases": ["downregulation of hyaluronan biosynthetic process", "down-regulation of hyaluronan formation", "inhibition of hyaluronan biosynthesis", "downregulation of hyaluronan biosynthesis", "down regulation of hyaluronan formation", "down regulation of hyaluronan biosynthetic process", "negative regulation of hyaluronan biosynthesis", "negative regulation of hyaluronan synthesis", "down regulation of hyaluronan synthesis", "inhibition of hyaluronan anabolism", "downregulation of hyaluronan formation", "down-regulation of hyaluronan anabolism", "negative regulation of hyaluronan anabolism", "down regulation of hyaluronan anabolism", "downregulation of hyaluronan synthesis", "down regulation of hyaluronan biosynthesis", "down-regulation of hyaluronan biosynthetic process", "negative regulation of hyaluronan formation", "inhibition of hyaluronan synthesis", "downregulation of hyaluronan anabolism", "inhibition of hyaluronan formation", "down-regulation of hyaluronan biosynthesis", "down-regulation of hyaluronan synthesis"], "types": ["T044"], "canonical_name": "negative regulation of hyaluronan biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269594", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hyaluronan biosynthetic process"}
{"concept_id": "C3269595", "aliases": ["activation of hyaluronan biosynthesis", "activation of hyaluronan anabolism", "upregulation of hyaluronan anabolism", "upregulation of hyaluronan biosynthesis", "up regulation of hyaluronan formation", "upregulation of hyaluronan formation", "up-regulation of hyaluronan biosynthesis", "activation of hyaluronan formation", "up-regulation of hyaluronan biosynthetic process", "up-regulation of hyaluronan anabolism", "up-regulation of hyaluronan formation", "up regulation of hyaluronan synthesis", "positive regulation of hyaluronan anabolism", "activation of hyaluronan synthesis", "positive regulation of hyaluronan formation", "upregulation of hyaluronan synthesis", "positive regulation of hyaluronan biosynthesis", "up regulation of hyaluronan biosynthetic process", "upregulation of hyaluronan biosynthetic process", "up regulation of hyaluronan anabolism", "up regulation of hyaluronan biosynthesis", "up-regulation of hyaluronan synthesis", "positive regulation of hyaluronan synthesis"], "types": ["T044"], "canonical_name": "positive regulation of hyaluronan biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269596", "aliases": [], "types": ["T044"], "canonical_name": "activation of hyaluronan biosynthetic process"}
{"concept_id": "C3269597", "aliases": ["regulation of G protein activated inward rectifier potassium channel activity", "regulation of G protein enhanced inward rectifier potassium channel activity", "regulation of G-protein enhanced inward rectifier potassium channel activity", "regulation of G-protein-enhanced inward rectifier potassium channel activity", "regulation of G-protein-activated inward rectifier potassium channel activity"], "types": ["T043"], "canonical_name": "regulation of G-protein activated inward rectifier potassium channel activity", "definition": "Any process that modulates the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity. [GOC:TermGenie]"}
{"concept_id": "C3269598", "aliases": ["upregulation of G protein enhanced inward rectifier potassium channel activity", "up regulation of G protein enhanced inward rectifier potassium channel activity", "up regulation of G-protein enhanced inward rectifier potassium channel activity", "up-regulation of G protein enhanced inward rectifier potassium channel activity", "up-regulation of G-protein activated inward rectifier potassium channel activity", "positive regulation of G protein activated inward rectifier potassium channel activity", "up regulation of G-protein-enhanced inward rectifier potassium channel activity", "upregulation of G-protein-enhanced inward rectifier potassium channel activity", "upregulation of G-protein activated inward rectifier potassium channel activity", "positive regulation of G-protein enhanced inward rectifier potassium channel activity", "up-regulation of G-protein-enhanced inward rectifier potassium channel activity", "upregulation of G protein activated inward rectifier potassium channel activity", "upregulation of G-protein-activated inward rectifier potassium channel activity", "positive regulation of G-protein-activated inward rectifier potassium channel activity", "up regulation of G protein activated inward rectifier potassium channel activity", "up regulation of G-protein-activated inward rectifier potassium channel activity", "up-regulation of G-protein-activated inward rectifier potassium channel activity", "up-regulation of G protein activated inward rectifier potassium channel activity", "up regulation of G-protein activated inward rectifier potassium channel activity", "up-regulation of G-protein enhanced inward rectifier potassium channel activity", "upregulation of G-protein enhanced inward rectifier potassium channel activity", "positive regulation of G-protein-enhanced inward rectifier potassium channel activity", "positive regulation of G protein enhanced inward rectifier potassium channel activity"], "types": ["T043"], "canonical_name": "positive regulation of G-protein activated inward rectifier potassium channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity. [GOC:TermGenie]"}
{"concept_id": "C3269599", "aliases": ["activation of G-protein-activated inward rectifier potassium channel activity", "activation of G-protein activated inward rectifier potassium channel activity"], "types": ["T043"], "canonical_name": "activation of G protein activated inward rectifier potassium channel activity"}
{"concept_id": "C3269600", "aliases": ["activation of G-protein-enhanced inward rectifier potassium channel activity", "activation of G-protein enhanced inward rectifier potassium channel activity"], "types": ["T043"], "canonical_name": "activation of G protein enhanced inward rectifier potassium channel activity"}
{"concept_id": "C3269601", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lipid binding", "definition": "Any process that modulates the frequency, rate or extent of lipid binding. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3269603", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lipid binding"}
{"concept_id": "C3269605", "aliases": [], "types": ["T044"], "canonical_name": "activation of lipid binding"}
{"concept_id": "C3269606", "aliases": ["regulation of renin release into blood stream"], "types": ["T042"], "canonical_name": "regulation of renin secretion into blood stream", "definition": "Any process that modulates the frequency, rate or extent of renin secretion into blood stream. [GOC:TermGenie]"}
{"concept_id": "C3269607", "aliases": ["negative regulation of renin release into blood stream", "down regulation of renin release into blood stream", "downregulation of renin release into blood stream", "down-regulation of renin secretion into blood stream", "down regulation of renin secretion into blood stream", "downregulation of renin secretion into blood stream", "down-regulation of renin release into blood stream"], "types": ["T043"], "canonical_name": "negative regulation of renin secretion into blood stream", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream. [GOC:TermGenie]"}
{"concept_id": "C3269608", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of renin release into blood stream"}
{"concept_id": "C3269609", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of renin secretion into blood stream"}
{"concept_id": "C3269610", "aliases": ["upregulation of renin release into blood stream", "positive regulation of renin release into blood stream", "activation of renin secretion into blood stream", "up regulation of renin release into blood stream", "upregulation of renin secretion into blood stream", "up-regulation of renin secretion into blood stream", "up regulation of renin secretion into blood stream", "activation of renin release into blood stream", "up-regulation of renin release into blood stream"], "types": ["T043"], "canonical_name": "positive regulation of renin secretion into blood stream", "definition": "Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream. [GOC:TermGenie]"}
{"concept_id": "C3269611", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chemokine activity", "definition": "Any process that modulates the frequency, rate or extent of chemokine activity. [GOC:TermGenie]"}
{"concept_id": "C3269613", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of chemokine activity"}
{"concept_id": "C3269614", "aliases": ["down regulation of phosphatidylcholine 2-acylhydrolase activity", "down-regulation of phosphatidolipase activity", "negative regulation of phosphatidylcholine 2-acylhydrolase activity", "down-regulation of phospholipase A2 activity", "negative regulation of phosphatidolipase activity", "downregulation of lecithinase A activity", "downregulation of phosphatidolipase activity", "down-regulation of phosphatidylcholine 2-acylhydrolase activity", "down-regulation of lecithinase A activity", "negative regulation of lecithinase A activity", "down regulation of phosphatidolipase activity", "downregulation of phospholipase A2 activity", "downregulation of phosphatidylcholine 2-acylhydrolase activity", "down regulation of phospholipase A2 activity", "down regulation of lecithinase A activity"], "types": ["T044"], "canonical_name": "negative regulation of phospholipase A2 activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity. [GOC:TermGenie]"}
{"concept_id": "C3269615", "aliases": ["down-regulation of cytosolic phospholipase A2 activity"], "types": ["T044"], "canonical_name": "down regulation of cytosolic phospholipase A2 activity"}
{"concept_id": "C3269616", "aliases": ["down-regulation of phosphatidase activity"], "types": ["T044"], "canonical_name": "down regulation of phosphatidase activity"}
{"concept_id": "C3269617", "aliases": ["down-regulation of phospholipase A"], "types": ["T044"], "canonical_name": "down regulation of phospholipase A"}
{"concept_id": "C3269618", "aliases": ["down-regulation of secreted phospholipase A2 activity"], "types": ["T044"], "canonical_name": "down regulation of secreted phospholipase A2 activity"}
{"concept_id": "C3269619", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of cytosolic phospholipase A2 activity"}
{"concept_id": "C3269620", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of phosphatidase activity"}
{"concept_id": "C3269621", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of phospholipase A"}
{"concept_id": "C3269622", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of secreted phospholipase A2 activity"}
{"concept_id": "C3269623", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytosolic phospholipase A2 activity"}
{"concept_id": "C3269624", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lecithinase A activity"}
{"concept_id": "C3269625", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidase activity"}
{"concept_id": "C3269626", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidolipase activity"}
{"concept_id": "C3269627", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylcholine 2-acylhydrolase activity"}
{"concept_id": "C3269628", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phospholipase A"}
{"concept_id": "C3269629", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phospholipase A2 activity"}
{"concept_id": "C3269630", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of secreted phospholipase A2 activity"}
{"concept_id": "C3269631", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cytosolic phospholipase A2 activity"}
{"concept_id": "C3269632", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphatidase activity"}
{"concept_id": "C3269633", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phospholipase A"}
{"concept_id": "C3269634", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of secreted phospholipase A2 activity"}
{"concept_id": "C3269636", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of arachidonic acid secretion"}
{"concept_id": "C3269637", "aliases": [], "types": ["T040"], "canonical_name": "regulation of seedling development", "definition": "Any process that modulates the frequency, rate or extent of seedling development. [GOC:TermGenie]"}
{"concept_id": "C3269638", "aliases": ["regulation of oligodendrocyte apoptosis"], "types": ["T043"], "canonical_name": "regulation of oligodendrocyte apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269639", "aliases": ["downregulation of oligodendrocyte apoptotic process", "negative regulation of oligodendrocyte apoptosis", "down regulation of oligodendrocyte apoptotic process", "down-regulation of oligodendrocyte apoptotic process", "downregulation of oligodendrocyte apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of oligodendrocyte apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269640", "aliases": ["down-regulation of oligodendrocyte apoptosis"], "types": ["T043"], "canonical_name": "down regulation of oligodendrocyte apoptosis"}
{"concept_id": "C3269641", "aliases": ["inhibition of oligodendrocyte apoptotic process"], "types": ["T043"], "canonical_name": "inhibition of oligodendrocyte apoptosis"}
{"concept_id": "C3269643", "aliases": ["activation of oligodendrocyte apoptotic process"], "types": ["T043"], "canonical_name": "activation of oligodendrocyte apoptosis"}
{"concept_id": "C3269644", "aliases": ["upregulation of oligodendrocyte apoptotic process", "up regulation of oligodendrocyte apoptosis", "up-regulation of oligodendrocyte apoptotic process", "up-regulation of oligodendrocyte apoptosis", "positive regulation of oligodendrocyte apoptosis", "up regulation of oligodendrocyte apoptotic process", "upregulation of oligodendrocyte apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of oligodendrocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269645", "aliases": ["up-regulation of BMP secretion", "activation of BMP protein secretion", "positive regulation of BMP protein secretion", "positive regulation of bone morphogenetic protein secretion", "up-regulation of BMP protein secretion", "up-regulation of bone morphogenetic protein secretion", "upregulation of BMP protein secretion", "up regulation of BMP protein secretion", "upregulation of BMP secretion", "activation of BMP secretion", "up regulation of BMP secretion", "upregulation of bone morphogenetic protein secretion", "up regulation of bone morphogenetic protein secretion"], "types": ["T043"], "canonical_name": "positive regulation of BMP secretion", "definition": "Any process that activates or increases the frequency, rate or extent of BMP secretion. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3269646", "aliases": [], "types": ["T043"], "canonical_name": "activation of bone morphogenetic protein secretion"}
{"concept_id": "C3269647", "aliases": ["regulation of nodal signalling pathway involved in determination of left/right asymmetry"], "types": ["T043"], "canonical_name": "regulation of nodal signaling pathway involved in determination of left/right asymmetry", "definition": "Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry. [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk]"}
{"concept_id": "C3269648", "aliases": ["negative regulation of nodal signalling pathway involved in determination of left/right asymmetry", "down-regulation of nodal signaling pathway involved in determination of left/right asymmetry", "down regulation of nodal signaling pathway involved in determination of left/right asymmetry", "downregulation of nodal signaling pathway involved in determination of left/right asymmetry"], "types": ["T043"], "canonical_name": "negative regulation of nodal signaling pathway involved in determination of left/right asymmetry", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry. [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk]"}
{"concept_id": "C3269649", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nodal signaling pathway involved in determination of left/right asymmetry"}
{"concept_id": "C3269650", "aliases": [], "types": ["T038"], "canonical_name": "regulation of Schwann cell migration", "definition": "Any process that modulates the frequency, rate or extent of Schwann cell migration. [GOC:sjw, GOC:TermGenie]"}
{"concept_id": "C3269651", "aliases": ["down regulation of Schwann cell migration", "down-regulation of Schwann cell migration", "downregulation of Schwann cell migration"], "types": ["T043"], "canonical_name": "negative regulation of Schwann cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration. [GOC:sjw, GOC:TermGenie]"}
{"concept_id": "C3269652", "aliases": ["upregulation of Schwann cell migration", "up-regulation of Schwann cell migration", "up regulation of Schwann cell migration"], "types": ["T043"], "canonical_name": "positive regulation of Schwann cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of Schwann cell migration. [GOC:sjw, GOC:TermGenie]"}
{"concept_id": "C3269653", "aliases": ["regulation of defence response to fungus", "regulation of defence response to fungi", "regulation of defense response to fungi"], "types": ["T039"], "canonical_name": "regulation of defense response to fungus", "definition": "Any process that modulates the frequency, rate or extent of defense response to fungus. [GOC:dhl, GOC:TermGenie, PMID:22242006]"}
{"concept_id": "C3269654", "aliases": ["regulation of mRNA catabolic process, deadenylation-dependent", "regulation of mRNA degradation, deadenylation-dependent decay", "regulation of mRNA catabolism, deadenylation-dependent", "regulation of mRNA catabolic process, deadenylylation-dependent", "regulation of mRNA catabolism, deadenylylation-dependent", "regulation of nuclear mRNA catabolic process, deadenylation-dependent decay", "regulation of mRNA breakdown, deadenylation-dependent decay", "regulation of deadenylation-dependent mRNA decay"], "types": ["T044"], "canonical_name": "regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "definition": "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. [GOC:mcc, GOC:TermGenie]"}
{"concept_id": "C3269655", "aliases": ["down-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "downregulation of nuclear mRNA catabolic process, deadenylation-dependent decay", "negative regulation of mRNA catabolic process, deadenylation-dependent", "down regulation of mRNA degradation, deadenylation-dependent decay", "negative regulation of mRNA catabolism, deadenylation-dependent", "downregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "down regulation of mRNA breakdown, deadenylation-dependent decay", "downregulation of mRNA catabolism, deadenylylation-dependent", "negative regulation of nuclear mRNA catabolic process, deadenylation-dependent decay", "down regulation of mRNA catabolic process, deadenylation-dependent", "downregulation of deadenylation-dependent mRNA decay", "down-regulation of mRNA degradation, deadenylation-dependent decay", "downregulation of mRNA degradation, deadenylation-dependent decay", "down-regulation of mRNA catabolism, deadenylation-dependent", "negative regulation of mRNA catabolism, deadenylylation-dependent", "down-regulation of deadenylation-dependent mRNA decay", "down regulation of mRNA catabolic process, deadenylylation-dependent", "negative regulation of mRNA degradation, deadenylation-dependent decay", "down-regulation of mRNA breakdown, deadenylation-dependent decay", "down-regulation of mRNA catabolism, deadenylylation-dependent", "downregulation of mRNA breakdown, deadenylation-dependent decay", "down-regulation of mRNA catabolic process, deadenylylation-dependent", "down regulation of mRNA catabolism, deadenylylation-dependent", "down-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay", "downregulation of mRNA catabolic process, deadenylation-dependent", "downregulation of mRNA catabolism, deadenylation-dependent", "negative regulation of deadenylation-dependent mRNA decay", "negative regulation of mRNA catabolic process, deadenylylation-dependent", "down-regulation of mRNA catabolic process, deadenylation-dependent", "negative regulation of mRNA breakdown, deadenylation-dependent decay", "down regulation of nuclear mRNA catabolic process, deadenylation-dependent decay", "down regulation of mRNA catabolism, deadenylation-dependent", "downregulation of mRNA catabolic process, deadenylylation-dependent", "down regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "down regulation of deadenylation-dependent mRNA decay"], "types": ["T044"], "canonical_name": "negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. [GOC:mcc, GOC:TermGenie]"}
{"concept_id": "C3269656", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of deadenylation-dependent mRNA decay"}
{"concept_id": "C3269657", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA breakdown, deadenylation-dependent decay"}
{"concept_id": "C3269658", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA catabolic process, deadenylation-dependent"}
{"concept_id": "C3269659", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA catabolic process, deadenylylation-dependent"}
{"concept_id": "C3269660", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA catabolism, deadenylation-dependent"}
{"concept_id": "C3269661", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA catabolism, deadenylylation-dependent"}
{"concept_id": "C3269662", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA degradation, deadenylation-dependent decay"}
{"concept_id": "C3269663", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nuclear mRNA catabolic process, deadenylation-dependent decay"}
{"concept_id": "C3269664", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"}
{"concept_id": "C3269665", "aliases": ["positive regulation of mRNA catabolism, deadenylation-dependent", "upregulation of mRNA catabolic process, deadenylation-dependent", "up regulation of mRNA degradation, deadenylation-dependent decay", "upregulation of deadenylation-dependent mRNA decay", "up-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay", "positive regulation of nuclear mRNA catabolic process, deadenylation-dependent decay", "positive regulation of deadenylation-dependent mRNA decay", "up regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "upregulation of mRNA degradation, deadenylation-dependent decay", "up regulation of mRNA catabolism, deadenylation-dependent", "up-regulation of mRNA catabolism, deadenylation-dependent", "upregulation of mRNA breakdown, deadenylation-dependent decay", "up-regulation of mRNA catabolic process, deadenylylation-dependent", "up-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "up-regulation of mRNA degradation, deadenylation-dependent decay", "upregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "positive regulation of mRNA degradation, deadenylation-dependent decay", "upregulation of nuclear mRNA catabolic process, deadenylation-dependent decay", "up-regulation of mRNA catabolism, deadenylylation-dependent", "up-regulation of mRNA catabolic process, deadenylation-dependent", "up regulation of mRNA catabolism, deadenylylation-dependent", "upregulation of mRNA catabolism, deadenylation-dependent", "up-regulation of deadenylation-dependent mRNA decay", "up regulation of mRNA breakdown, deadenylation-dependent decay", "positive regulation of mRNA catabolic process, deadenylylation-dependent", "up regulation of mRNA catabolic process, deadenylation-dependent", "up regulation of nuclear mRNA catabolic process, deadenylation-dependent decay", "positive regulation of mRNA catabolism, deadenylylation-dependent", "upregulation of mRNA catabolism, deadenylylation-dependent", "up-regulation of mRNA breakdown, deadenylation-dependent decay", "positive regulation of mRNA breakdown, deadenylation-dependent decay", "upregulation of mRNA catabolic process, deadenylylation-dependent", "up regulation of mRNA catabolic process, deadenylylation-dependent", "positive regulation of mRNA catabolic process, deadenylation-dependent", "up regulation of deadenylation-dependent mRNA decay"], "types": ["T044"], "canonical_name": "positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "definition": "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. [GOC:mcc, GOC:TermGenie]"}
{"concept_id": "C3269666", "aliases": [], "types": ["T044"], "canonical_name": "activation of mRNA breakdown, deadenylation-dependent decay"}
{"concept_id": "C3269667", "aliases": ["activation of mRNA catabolic process, deadenylylation-dependent", "activation of mRNA catabolic process, deadenylation-dependent", "activation of mRNA degradation, deadenylation-dependent decay", "activation of nuclear mRNA catabolic process, deadenylation-dependent decay", "activation of mRNA catabolism, deadenylylation-dependent", "activation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "activation of mRNA catabolism, deadenylation-dependent"], "types": ["T044"], "canonical_name": "activation of deadenylation-dependent mRNA decay"}
{"concept_id": "C3269668", "aliases": ["regulation of skeletal trabecula formation", "regulation of skeletal trabeculation", "regulation of bone trabeculation"], "types": ["T042"], "canonical_name": "regulation of bone trabecula formation", "definition": "Any process that modulates the frequency, rate or extent of bone trabecula formation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269669", "aliases": [], "types": ["T042"], "canonical_name": "regulation of bone trabecula biogenesis"}
{"concept_id": "C3269670", "aliases": [], "types": ["T042"], "canonical_name": "regulation of skeletal trabecula biogenesis"}
{"concept_id": "C3269671", "aliases": ["down regulation of skeletal trabeculation", "down-regulation of skeletal trabeculation", "downregulation of skeletal trabecula formation", "down regulation of bone trabeculation", "negative regulation of skeletal trabeculation", "downregulation of bone trabecula formation", "down regulation of skeletal trabecula formation", "downregulation of bone trabeculation", "negative regulation of skeletal trabecula formation", "negative regulation of bone trabeculation", "down regulation of bone trabecula formation", "downregulation of skeletal trabeculation", "down-regulation of skeletal trabecula formation", "down-regulation of bone trabeculation", "down-regulation of bone trabecula formation"], "types": ["T038"], "canonical_name": "negative regulation of bone trabecula formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269672", "aliases": ["down-regulation of bone trabecula biogenesis"], "types": ["T038"], "canonical_name": "down regulation of bone trabecula biogenesis"}
{"concept_id": "C3269673", "aliases": ["down-regulation of skeletal trabecula biogenesis"], "types": ["T038"], "canonical_name": "down regulation of skeletal trabecula biogenesis"}
{"concept_id": "C3269674", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of bone trabecula biogenesis"}
{"concept_id": "C3269675", "aliases": ["inhibition of skeletal trabeculation", "inhibition of bone trabeculation", "inhibition of skeletal trabecula formation"], "types": ["T038"], "canonical_name": "inhibition of bone trabecula formation"}
{"concept_id": "C3269676", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of skeletal trabecula biogenesis"}
{"concept_id": "C3269677", "aliases": ["downregulation of skeletal trabecula biogenesis", "negative regulation of skeletal trabecula biogenesis", "negative regulation of bone trabecula biogenesis"], "types": ["T038"], "canonical_name": "downregulation of bone trabecula biogenesis"}
{"concept_id": "C3269678", "aliases": ["upregulation of skeletal trabeculation", "upregulation of skeletal trabecula formation", "up-regulation of skeletal trabecula formation", "up regulation of skeletal trabeculation", "positive regulation of bone trabeculation", "up-regulation of bone trabeculation", "up regulation of bone trabeculation", "positive regulation of skeletal trabecula formation", "upregulation of bone trabecula formation", "upregulation of bone trabeculation", "up-regulation of skeletal trabeculation", "up regulation of skeletal trabecula formation", "positive regulation of skeletal trabeculation", "up regulation of bone trabecula formation", "up-regulation of bone trabecula formation"], "types": ["T038"], "canonical_name": "positive regulation of bone trabecula formation", "definition": "Any process that activates or increases the frequency, rate or extent of bone trabecula formation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269679", "aliases": ["activation of skeletal trabecula formation", "activation of skeletal trabeculation", "activation of bone trabeculation"], "types": ["T038"], "canonical_name": "activation of bone trabecula formation"}
{"concept_id": "C3269680", "aliases": ["activation of skeletal trabecula biogenesis"], "types": ["T038"], "canonical_name": "activation of bone trabecula biogenesis"}
{"concept_id": "C3269681", "aliases": ["upregulation of skeletal trabecula biogenesis", "up-regulation of skeletal trabecula biogenesis", "up-regulation of bone trabecula biogenesis", "up regulation of bone trabecula biogenesis", "positive regulation of skeletal trabecula biogenesis", "up regulation of skeletal trabecula biogenesis", "upregulation of bone trabecula biogenesis"], "types": ["T038"], "canonical_name": "positive regulation of bone trabecula biogenesis"}
{"concept_id": "C3269682", "aliases": [], "types": ["T042"], "canonical_name": "regulation of bone mineralization involved in bone maturation", "definition": "Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269683", "aliases": ["down-regulation of bone mineralization involved in bone maturation", "down regulation of bone mineralization involved in bone maturation", "downregulation of bone mineralization involved in bone maturation"], "types": ["T042"], "canonical_name": "negative regulation of bone mineralization involved in bone maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269684", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of bone mineralization involved in bone maturation"}
{"concept_id": "C3269685", "aliases": ["up-regulation of bone mineralization involved in bone maturation", "up regulation of bone mineralization involved in bone maturation", "upregulation of bone mineralization involved in bone maturation"], "types": ["T042"], "canonical_name": "positive regulation of bone mineralization involved in bone maturation", "definition": "Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269686", "aliases": [], "types": ["T042"], "canonical_name": "activation of bone mineralization involved in bone maturation"}
{"concept_id": "C3269687", "aliases": ["DNA organisation in plastid", "plastidial DNA packaging", "DNA organization in plastid", "plastid DNA packaging"], "types": ["T045"], "canonical_name": "plastid chromosome packaging", "definition": "A process in which plastidial DNA and associated proteins organize into a compact, orderly structure. [GOC:emb, GOC:TermGenie, PMID:12081370]"}
{"concept_id": "C3269688", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phospholipid scramblase activity", "definition": "Any process that modulates the frequency, rate or extent of phospholipid scramblase activity. [GOC:TermGenie]"}
{"concept_id": "C3269690", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phospholipid scramblase activity"}
{"concept_id": "C3269691", "aliases": ["up regulation of phospholipid scramblase activity", "upregulation of phospholipid scramblase activity", "up-regulation of phospholipid scramblase activity"], "types": ["T038"], "canonical_name": "positive regulation of phospholipid scramblase activity", "definition": "Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity. [GOC:TermGenie]"}
{"concept_id": "C3269692", "aliases": [], "types": ["T038"], "canonical_name": "activation of phospholipid scramblase activity"}
{"concept_id": "C3269693", "aliases": ["nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "nodal signaling of determination of left/right asymmetry in lateral mesoderm", "nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm"], "types": ["T044"], "canonical_name": "nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "definition": "The series of molecular signals initiated by a nodal protein binding to an activin receptor on the surface of a target cell, which contributes to the establishment of lateral mesoderm with respect to the left and right halves. [GOC:BHF, GOC:TermGenie, GOC:vk]"}
{"concept_id": "C3269697", "aliases": ["regulation of GDNF secretion", "regulation of glial cell line-derived neurotrophic factor secretion"], "types": ["T043"], "canonical_name": "regulation of glial cell-derived neurotrophic factor secretion"}
{"concept_id": "C3269698", "aliases": ["negative regulation of glial cell line-derived neurotrophic factor secretion", "negative regulation of GDNF secretion", "negative regulation of glial cell-derived neurotrophic factor secretion"], "types": ["T043"], "canonical_name": "negative regulation of glial cell-derived neurotrophic factor production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor production. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3269699", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of GDNF secretion"}
{"concept_id": "C3269700", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glial cell line-derived neurotrophic factor secretion"}
{"concept_id": "C3269701", "aliases": ["activation of glial cell line-derived neurotrophic factor secretion", "positive regulation of glial cell line-derived neurotrophic factor secretion"], "types": ["T043"], "canonical_name": "positive regulation of glial cell-derived neurotrophic factor secretion"}
{"concept_id": "C3269702", "aliases": ["regulation of glucocorticoid mediated signalling"], "types": ["T044"], "canonical_name": "regulation of glucocorticoid mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of glucocorticoid mediated signaling pathway. [GOC:TermGenie]"}
{"concept_id": "C3269703", "aliases": ["negative regulation of glucocorticoid mediated signalling", "downregulation of glucocorticoid mediated signaling pathway", "downregulation of glucocorticoid mediated signalling", "down-regulation of glucocorticoid mediated signalling", "down regulation of glucocorticoid mediated signalling", "down regulation of glucocorticoid mediated signaling pathway", "down-regulation of glucocorticoid mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of glucocorticoid mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid mediated signaling pathway. [GOC:TermGenie]"}
{"concept_id": "C3269704", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucocorticoid mediated signaling pathway"}
{"concept_id": "C3269705", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucocorticoid mediated signalling"}
{"concept_id": "C3269707", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucocorticoid mediated signaling pathway"}
{"concept_id": "C3269708", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucocorticoid mediated signalling"}
{"concept_id": "C3269709", "aliases": ["regulation of flagellum movement"], "types": ["T043"], "canonical_name": "regulation of flagellar movement"}
{"concept_id": "C3269710", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of flagellum movement"}
{"concept_id": "C3269712", "aliases": ["positive regulation of flagellum movement"], "types": ["T043"], "canonical_name": "positive regulation of flagellar movement"}
{"concept_id": "C3269714", "aliases": ["regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry"], "types": ["T038"], "canonical_name": "regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "definition": "Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm. [GOC:BHF, GOC:TermGenie, GOC:vk]"}
{"concept_id": "C3269715", "aliases": ["negative regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "down-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "downregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry"], "types": ["T038"], "canonical_name": "negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm. [GOC:BHF, GOC:TermGenie, GOC:vk, PMID:15084459]"}
{"concept_id": "C3269716", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry"}
{"concept_id": "C3269717", "aliases": ["regulation of aflatoxin biosynthesis", "regulation of aflatoxin anabolism", "regulation of aflatoxin synthesis", "regulation of aflatoxin formation"], "types": ["T044"], "canonical_name": "regulation of aflatoxin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of aflatoxin biosynthetic process. [GOC:di]"}
{"concept_id": "C3269718", "aliases": ["down-regulation of aflatoxin biosynthesis", "downregulation of aflatoxin anabolism", "negative regulation of aflatoxin formation", "negative regulation of aflatoxin synthesis", "down-regulation of aflatoxin formation", "downregulation of aflatoxin synthesis", "down regulation of aflatoxin formation", "down regulation of aflatoxin anabolism", "down regulation of aflatoxin synthesis", "down-regulation of aflatoxin synthesis", "down regulation of aflatoxin biosynthesis", "downregulation of aflatoxin formation", "down-regulation of aflatoxin anabolism", "negative regulation of aflatoxin anabolism", "down-regulation of aflatoxin biosynthetic process", "downregulation of aflatoxin biosynthesis", "downregulation of aflatoxin biosynthetic process", "negative regulation of aflatoxin biosynthesis", "down regulation of aflatoxin biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of aflatoxin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aflatoxin biosynthetic process. [GOC:di]"}
{"concept_id": "C3269719", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aflatoxin anabolism"}
{"concept_id": "C3269720", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aflatoxin biosynthesis"}
{"concept_id": "C3269721", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aflatoxin biosynthetic process"}
{"concept_id": "C3269722", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aflatoxin formation"}
{"concept_id": "C3269723", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aflatoxin synthesis"}
{"concept_id": "C3269724", "aliases": ["up regulation of aflatoxin biosynthesis", "upregulation of aflatoxin synthesis", "up regulation of aflatoxin synthesis", "up regulation of aflatoxin formation", "positive regulation of aflatoxin synthesis", "upregulation of aflatoxin formation", "up-regulation of aflatoxin biosynthesis", "up-regulation of aflatoxin synthesis", "up regulation of aflatoxin biosynthetic process", "up regulation of aflatoxin anabolism", "up-regulation of aflatoxin biosynthetic process", "upregulation of aflatoxin biosynthetic process", "upregulation of aflatoxin anabolism", "positive regulation of aflatoxin formation", "positive regulation of aflatoxin biosynthesis", "up-regulation of aflatoxin formation", "up-regulation of aflatoxin anabolism", "positive regulation of aflatoxin anabolism", "upregulation of aflatoxin biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of aflatoxin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of aflatoxin biosynthetic process. [GOC:di]"}
{"concept_id": "C3269725", "aliases": ["activation of aflatoxin biosynthetic process", "activation of aflatoxin synthesis", "activation of aflatoxin biosynthesis", "activation of aflatoxin formation"], "types": ["T044"], "canonical_name": "activation of aflatoxin anabolism"}
{"concept_id": "C3269726", "aliases": ["regulation of protein localisation to nucleus", "regulation of protein localization in cell nucleus", "regulation of protein localization in nucleus"], "types": ["T043"], "canonical_name": "regulation of protein localization to nucleus", "definition": "Any process that modulates the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]"}
{"concept_id": "C3269727", "aliases": ["down-regulation of protein localisation to nucleus", "downregulation of protein localization in nucleus", "downregulation of protein localization in cell nucleus", "negative regulation of protein localisation to nucleus", "down-regulation of protein localization in cell nucleus", "down regulation of protein localization to nucleus", "down-regulation of protein localization in nucleus", "down-regulation of protein localization to nucleus", "negative regulation of protein localization in nucleus", "downregulation of protein localisation to nucleus", "negative regulation of protein localization in cell nucleus", "downregulation of protein localization to nucleus", "down regulation of protein localisation to nucleus", "down regulation of protein localization in cell nucleus", "down regulation of protein localization in nucleus"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to nucleus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]"}
{"concept_id": "C3269728", "aliases": ["up-regulation of protein localization to nucleus", "upregulation of protein localization in nucleus", "activation of protein localisation to nucleus", "up-regulation of protein localization in cell nucleus", "activation of protein localization to nucleus", "up-regulation of protein localisation to nucleus", "positive regulation of protein localization in cell nucleus", "up regulation of protein localisation to nucleus", "positive regulation of protein localisation to nucleus", "up regulation of protein localization to nucleus", "upregulation of protein localisation to nucleus", "upregulation of protein localization in cell nucleus", "upregulation of protein localization to nucleus", "positive regulation of protein localization in nucleus", "up regulation of protein localization in cell nucleus", "up regulation of protein localization in nucleus", "activation of protein localization in nucleus", "up-regulation of protein localization in nucleus"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to nucleus", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]"}
{"concept_id": "C3269729", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein localization in cell nucleus"}
{"concept_id": "C3269731", "aliases": ["regulation of xanthone-containing compound synthesis", "regulation of xanthone-containing compound anabolism", "regulation of xanthone-containing compound formation", "regulation of xanthone-containing compound biosynthesis"], "types": ["T040"], "canonical_name": "regulation of xanthone-containing compound biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of xanthone-containing compound biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269732", "aliases": ["regulation of xanthone biosynthetic process"], "types": ["T040"], "canonical_name": "regulation of xanthone biosynthesis"}
{"concept_id": "C3269733", "aliases": ["down-regulation of xanthone-containing compound anabolism", "down regulation of xanthone-containing compound synthesis", "inhibition of xanthone-containing compound biosynthesis", "down-regulation of xanthone-containing compound biosynthetic process", "downregulation of xanthone-containing compound biosynthetic process", "down regulation of xanthone-containing compound biosynthetic process", "down-regulation of xanthone-containing compound biosynthesis", "negative regulation of xanthones anabolism", "down regulation of xanthone-containing compound biosynthesis", "downregulation of xanthone-containing compound formation", "down-regulation of xanthone-containing compound formation", "inhibition of xanthone-containing compound synthesis", "negative regulation of xanthone-containing compound anabolism", "inhibition of xanthone-containing compound anabolism", "downregulation of xanthone-containing compound synthesis", "negative regulation of xanthone-containing compound formation", "downregulation of xanthone-containing compound biosynthesis", "downregulation of xanthone-containing compound anabolism", "down regulation of xanthone-containing compound anabolism", "down-regulation of xanthone-containing compound synthesis", "inhibition of xanthone-containing compound formation", "down regulation of xanthone-containing compound formation", "negative regulation of xanthone-containing compound biosynthesis", "negative regulation of xanthone-containing compound synthesis"], "types": ["T044"], "canonical_name": "negative regulation of xanthone-containing compound biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of xanthone-containing compound biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269734", "aliases": ["down-regulation of xanthone biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of xanthone biosynthesis"}
{"concept_id": "C3269735", "aliases": ["down-regulation of xanthone biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of xanthone biosynthetic process"}
{"concept_id": "C3269736", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of xanthone biosynthesis"}
{"concept_id": "C3269737", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of xanthone biosynthetic process"}
{"concept_id": "C3269738", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of xanthone biosynthesis"}
{"concept_id": "C3269739", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of xanthone biosynthetic process"}
{"concept_id": "C3269740", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of xanthone-containing compound biosynthetic process"}
{"concept_id": "C3269741", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of xanthone biosynthesis"}
{"concept_id": "C3269742", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of xanthone biosynthetic process"}
{"concept_id": "C3269743", "aliases": ["up regulation of xanthone-containing compound biosynthesis", "activation of xanthone-containing compound biosynthesis", "positive regulation of xanthone-containing compound biosynthesis", "up-regulation of xanthone-containing compound biosynthesis", "up-regulation of xanthone-containing compound anabolism", "positive regulation of xanthone-containing compound synthesis", "positive regulation of xanthone-containing compound formation", "positive regulation of xanthone-containing compound anabolism", "up-regulation of xanthone-containing compound biosynthetic process", "activation of xanthone-containing compound formation", "up regulation of xanthone-containing compound anabolism", "upregulation of xanthone-containing compound anabolism", "upregulation of xanthone-containing compound formation", "up regulation of xanthone-containing compound biosynthetic process", "up-regulation of xanthone-containing compound synthesis", "upregulation of xanthone-containing compound biosynthetic process", "upregulation of xanthone-containing compound biosynthesis", "activation of xanthone-containing compound synthesis", "up-regulation of xanthone-containing compound formation", "up regulation of xanthone-containing compound formation", "up regulation of xanthone-containing compound synthesis", "upregulation of xanthone-containing compound synthesis", "activation of xanthone-containing compound anabolism"], "types": ["T044"], "canonical_name": "positive regulation of xanthone-containing compound biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of xanthone-containing compound biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269744", "aliases": ["activation of xanthone biosynthetic process"], "types": ["T044"], "canonical_name": "activation of xanthone biosynthesis"}
{"concept_id": "C3269745", "aliases": [], "types": ["T044"], "canonical_name": "activation of xanthone-containing compound biosynthetic process"}
{"concept_id": "C3269746", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of xanthone biosynthesis"}
{"concept_id": "C3269747", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of xanthone biosynthetic process"}
{"concept_id": "C3269748", "aliases": ["up-regulation of xanthone biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of xanthone biosynthesis"}
{"concept_id": "C3269749", "aliases": ["up-regulation of xanthone biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of xanthone biosynthetic process"}
{"concept_id": "C3269750", "aliases": ["upregulation of xanthone biosynthetic process"], "types": ["T044"], "canonical_name": "upregulation of xanthone biosynthesis"}
{"concept_id": "C3269751", "aliases": ["down-regulation of clathrin-mediated endocytosis", "down-regulation of clathrin-dependent endocytosis", "downregulation of clathrin-dependent endocytosis", "negative regulation of clathrin coated pit-dependent endocytosis", "inhibition of clathrin coated pit-dependent endocytosis", "inhibition of clathrin-dependent endocytosis", "negative regulation of clathrin-mediated endocytosis", "down regulation of clathrin-dependent endocytosis", "downregulation of clathrin coated pit-dependent endocytosis", "down regulation of clathrin coated pit-dependent endocytosis", "downregulation of clathrin-mediated endocytosis", "down-regulation of clathrin coated pit-dependent endocytosis", "down regulation of clathrin-mediated endocytosis"], "types": ["T043"], "canonical_name": "negative regulation of clathrin-dependent endocytosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis. [GOC:TermGenie]"}
{"concept_id": "C3269752", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of clathrin-mediated endocytosis"}
{"concept_id": "C3269753", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell adhesion involved in single-species biofilm formation", "definition": "Any process that modulates the frequency, rate or extent of cell adhesion involved in single-species biofilm formation. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269754", "aliases": ["down-regulation of cell adhesion during single-species biofilm formation", "downregulation of cell adhesion during single-species biofilm formation"], "types": ["T043"], "canonical_name": "down regulation of cell adhesion during single-species biofilm formation"}
{"concept_id": "C3269755", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell adhesion during single-species biofilm formation"}
{"concept_id": "C3269756", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell adhesion during single-species biofilm formation"}
{"concept_id": "C3269757", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell adhesion during single-species biofilm formation"}
{"concept_id": "C3269758", "aliases": ["up regulation of cell adhesion involved in single-species biofilm formation", "upregulation of cell adhesion involved in single-species biofilm formation", "up-regulation of cell adhesion involved in single-species biofilm formation", "positive regulation of cell adhesion during single-species biofilm formation"], "types": ["T043"], "canonical_name": "positive regulation of cell adhesion involved in single-species biofilm formation", "definition": "Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269759", "aliases": ["upregulation of cell adhesion during single-species biofilm formation", "up-regulation of cell adhesion during single-species biofilm formation"], "types": ["T043"], "canonical_name": "up regulation of cell adhesion during single-species biofilm formation"}
{"concept_id": "C3269760", "aliases": [], "types": ["T043"], "canonical_name": "regulation of single-species biofilm formation", "definition": "Any process that modulates the frequency, rate or extent of single-species biofilm formation. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269762", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of single-species biofilm formation"}
{"concept_id": "C3269763", "aliases": ["up-regulation of single-species biofilm formation", "upregulation of single-species biofilm formation", "up regulation of single-species biofilm formation"], "types": ["T038"], "canonical_name": "positive regulation of single-species biofilm formation", "definition": "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269764", "aliases": [], "types": ["T038"], "canonical_name": "activation of single-species biofilm formation"}
{"concept_id": "C3269765", "aliases": [], "types": ["T043"], "canonical_name": "regulation of oocyte maturation", "definition": "Any process that modulates the frequency, rate or extent of oocyte maturation. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3269766", "aliases": ["up-regulation of oocyte maturation", "upregulation of oocyte maturation", "up regulation of oocyte maturation"], "types": ["T043"], "canonical_name": "positive regulation of oocyte maturation", "definition": "Any process that activates or increases the frequency, rate or extent of oocyte maturation. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3269767", "aliases": ["regulation of penicillin formation", "regulation of penicillin synthesis", "regulation of penicillin anabolism", "regulation of penicillin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of penicillin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of penicillin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269768", "aliases": ["downregulation of penicillin biosynthetic process", "down regulation of penicillin anabolism", "negative regulation of penicillin formation", "downregulation of penicillin anabolism", "down regulation of penicillin biosynthesis", "downregulation of penicillin biosynthesis", "inhibition of penicillin synthesis", "down regulation of penicillin biosynthetic process", "downregulation of penicillin synthesis", "down regulation of penicillin synthesis", "negative regulation of penicillin biosynthesis", "inhibition of penicillin anabolism", "down-regulation of penicillin biosynthetic process", "down-regulation of penicillin synthesis", "inhibition of penicillin biosynthesis", "down-regulation of penicillin biosynthesis", "inhibition of penicillin formation", "down regulation of penicillin formation", "down-regulation of penicillin formation", "negative regulation of penicillin synthesis", "downregulation of penicillin formation", "down-regulation of penicillin anabolism", "negative regulation of penicillin anabolism"], "types": ["T044"], "canonical_name": "negative regulation of penicillin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of penicillin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269769", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of penicillin biosynthetic process"}
{"concept_id": "C3269770", "aliases": ["up-regulation of penicillin biosynthesis", "activation of penicillin biosynthesis", "activation of penicillin anabolism", "upregulation of penicillin anabolism", "upregulation of penicillin biosynthetic process", "up regulation of penicillin anabolism", "upregulation of penicillin formation", "upregulation of penicillin synthesis", "up regulation of penicillin biosynthesis", "positive regulation of penicillin synthesis", "activation of penicillin formation", "activation of penicillin synthesis", "upregulation of penicillin biosynthesis", "up regulation of penicillin biosynthetic process", "positive regulation of penicillin biosynthesis", "up-regulation of penicillin biosynthetic process", "up-regulation of penicillin anabolism", "up regulation of penicillin formation", "up regulation of penicillin synthesis", "positive regulation of penicillin formation", "up-regulation of penicillin synthesis", "up-regulation of penicillin formation", "positive regulation of penicillin anabolism"], "types": ["T044"], "canonical_name": "positive regulation of penicillin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of penicillin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269771", "aliases": [], "types": ["T044"], "canonical_name": "activation of penicillin biosynthetic process"}
{"concept_id": "C3269772", "aliases": ["positive regulation of protein export from nucleus involved in meiotic anaphase II"], "types": ["T043"], "canonical_name": "positive regulation of protein export from nucleus during meiotic anaphase II", "definition": "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm, during anaphase occurring as part of meiosis II. [GOC:al, GOC:TermGenie, PMID:20970342]"}
{"concept_id": "C3269773", "aliases": ["mesenchymal cell apoptosis involved in metanephros development"], "types": ["T043"], "canonical_name": "mesenchymal cell apoptotic process involved in metanephros development", "definition": "Any mesenchymal cell apoptotic process that is involved in metanephros development. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269779", "aliases": ["apoptotic program of metanephric collecting duct development", "apoptotic process of metanephric collecting duct development", "apoptotic cell death of metanephric collecting duct development", "apoptosis of metanephric collecting duct development", "programmed cell death by apoptosis of metanephric collecting duct development", "apoptotic programmed cell death of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "apoptotic process involved in metanephric collecting duct development", "definition": "Any apoptotic process that is involved in metanephric collecting duct development. [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269780", "aliases": [], "types": ["T043"], "canonical_name": "signaling (initiator) caspase activity of metanephric collecting duct development"}
{"concept_id": "C3269781", "aliases": [], "types": ["T043"], "canonical_name": "type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269782", "aliases": ["programmed cell death by apoptosis of metanephric nephron tubule development", "apoptosis of metanephric nephron tubule development", "apoptotic process of metanephric nephron tubule development", "apoptotic program of metanephric nephron tubule development", "apoptotic programmed cell death of metanephric nephron tubule development", "apoptotic cell death of metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "apoptotic process involved in metanephric nephron tubule development", "definition": "Any apoptotic process that is involved in metanephric nephron tubule development. [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269783", "aliases": [], "types": ["T043"], "canonical_name": "signaling (initiator) caspase activity of metanephric nephron tubule development"}
{"concept_id": "C3269784", "aliases": [], "types": ["T043"], "canonical_name": "type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269785", "aliases": [], "types": ["T042"], "canonical_name": "regulation of pronephric nephron tubule development", "definition": "Any process that modulates the frequency, rate or extent of pronephric nephron tubule development. [GOC:TermGenie]"}
{"concept_id": "C3269786", "aliases": ["down-regulation of pronephric nephron tubule development", "down regulation of pronephric nephron tubule development", "downregulation of pronephric nephron tubule development"], "types": ["T038"], "canonical_name": "negative regulation of pronephric nephron tubule development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pronephric nephron tubule development. [GOC:bf, GOC:TermGenie, PMID:9758706]"}
{"concept_id": "C3269787", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of pronephric nephron tubule development"}
{"concept_id": "C3269788", "aliases": ["regulation of cardiolipin metabolism"], "types": ["T043"], "canonical_name": "regulation of cardiolipin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of cardiolipin metabolic process. [GOC:TermGenie]"}
{"concept_id": "C3269789", "aliases": ["regulation of diphosphatidylglycerol metabolism"], "types": ["T043"], "canonical_name": "regulation of diphosphatidylglycerol metabolic process"}
{"concept_id": "C3269790", "aliases": ["downregulation of cardiolipin metabolic process", "down-regulation of cardiolipin metabolism", "down regulation of cardiolipin metabolism", "inhibition of cardiolipin metabolism", "down-regulation of cardiolipin metabolic process", "down regulation of cardiolipin metabolic process", "negative regulation of cardiolipin metabolism", "downregulation of cardiolipin metabolism"], "types": ["T044"], "canonical_name": "negative regulation of cardiolipin metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiolipin metabolic process. [GOC:TermGenie]"}
{"concept_id": "C3269791", "aliases": ["down-regulation of diphosphatidylglycerol metabolic process"], "types": ["T044"], "canonical_name": "down regulation of diphosphatidylglycerol metabolic process"}
{"concept_id": "C3269792", "aliases": ["down-regulation of diphosphatidylglycerol metabolism"], "types": ["T044"], "canonical_name": "down regulation of diphosphatidylglycerol metabolism"}
{"concept_id": "C3269793", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of diphosphatidylglycerol metabolic process"}
{"concept_id": "C3269794", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of diphosphatidylglycerol metabolism"}
{"concept_id": "C3269795", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cardiolipin metabolic process"}
{"concept_id": "C3269796", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of diphosphatidylglycerol metabolic process"}
{"concept_id": "C3269797", "aliases": ["negative regulation of diphosphatidylglycerol metabolic process", "negative regulation of diphosphatidylglycerol metabolism"], "types": ["T044"], "canonical_name": "inhibition of diphosphatidylglycerol metabolism"}
{"concept_id": "C3269798", "aliases": ["up regulation of cardiolipin metabolism", "upregulation of cardiolipin metabolism", "up-regulation of cardiolipin metabolic process", "activation of cardiolipin metabolism", "up-regulation of cardiolipin metabolism", "upregulation of cardiolipin metabolic process", "positive regulation of cardiolipin metabolism", "up regulation of cardiolipin metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of cardiolipin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cardiolipin metabolic process. [GOC:TermGenie]"}
{"concept_id": "C3269799", "aliases": [], "types": ["T044"], "canonical_name": "activation of cardiolipin metabolic process"}
{"concept_id": "C3269800", "aliases": ["positive regulation of diphosphatidylglycerol metabolic process", "upregulation of diphosphatidylglycerol metabolic process", "positive regulation of diphosphatidylglycerol metabolism", "upregulation of diphosphatidylglycerol metabolism", "activation of diphosphatidylglycerol metabolism"], "types": ["T044"], "canonical_name": "activation of diphosphatidylglycerol metabolic process"}
{"concept_id": "C3269801", "aliases": ["up-regulation of diphosphatidylglycerol metabolic process"], "types": ["T044"], "canonical_name": "up regulation of diphosphatidylglycerol metabolic process"}
{"concept_id": "C3269802", "aliases": ["up-regulation of diphosphatidylglycerol metabolism"], "types": ["T044"], "canonical_name": "up regulation of diphosphatidylglycerol metabolism"}
{"concept_id": "C3269803", "aliases": ["regulation of mesenchymal cell apoptosis involved in metanephros development"], "types": ["T043"], "canonical_name": "regulation of mesenchymal cell apoptotic process involved in metanephros development", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269805", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mesenchymal cell apoptosis involved in metanephros development"}
{"concept_id": "C3269806", "aliases": ["downregulation of mesenchymal cell apoptosis involved in metanephros development", "negative regulation of mesenchymal cell apoptosis involved in metanephros development", "down regulation of mesenchymal cell apoptosis involved in metanephros development", "down-regulation of mesenchymal cell apoptosis involved in metanephros development"], "types": ["T043"], "canonical_name": "negative regulation of mesenchymal cell apoptotic process involved in metanephros development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269808", "aliases": [], "types": ["T043"], "canonical_name": "activation of mesenchymal cell apoptosis involved in metanephros development"}
{"concept_id": "C3269809", "aliases": ["upregulation of mesenchymal cell apoptosis involved in metanephros development", "up regulation of mesenchymal cell apoptosis involved in metanephros development", "positive regulation of mesenchymal cell apoptosis involved in metanephros development", "up-regulation of mesenchymal cell apoptosis involved in metanephros development"], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal cell apoptotic process involved in metanephros development", "definition": "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development. [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269810", "aliases": ["regulation of apoptosis of metanephric collecting duct development", "regulation of apoptotic program of metanephric collecting duct development", "regulation of programmed cell death by apoptosis of metanephric collecting duct development", "regulation of apoptotic cell death of metanephric collecting duct development", "regulation of apoptotic process of metanephric collecting duct development", "regulation of apoptotic programmed cell death of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "regulation of apoptotic process involved in metanephric collecting duct development", "definition": "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development. [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269811", "aliases": [], "types": ["T043"], "canonical_name": "regulation of signaling (initiator) caspase activity of metanephric collecting duct development"}
{"concept_id": "C3269812", "aliases": [], "types": ["T043"], "canonical_name": "regulation of type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269813", "aliases": ["down-regulation of apoptotic cell death of metanephric collecting duct development", "negative regulation of apoptotic process of metanephric collecting duct development", "down regulation of apoptotic process of metanephric collecting duct development", "downregulation of apoptotic process of metanephric collecting duct development", "down-regulation of apoptotic process involved in metanephric collecting duct development", "negative regulation of apoptotic cell death of metanephric collecting duct development", "downregulation of programmed cell death by apoptosis of metanephric collecting duct development", "inhibition of programmed cell death by apoptosis of metanephric collecting duct development", "down regulation of apoptotic process involved in metanephric collecting duct development", "down regulation of apoptotic programmed cell death of metanephric collecting duct development", "inhibition of apoptotic programmed cell death of metanephric collecting duct development", "down regulation of apoptotic cell death of metanephric collecting duct development", "down-regulation of apoptotic programmed cell death of metanephric collecting duct development", "inhibition of apoptotic process of metanephric collecting duct development", "negative regulation of apoptotic programmed cell death of metanephric collecting duct development", "negative regulation of programmed cell death by apoptosis of metanephric collecting duct development", "downregulation of apoptotic process involved in metanephric collecting duct development", "down regulation of programmed cell death by apoptosis of metanephric collecting duct development", "downregulation of apoptotic cell death of metanephric collecting duct development", "inhibition of apoptotic cell death of metanephric collecting duct development", "down-regulation of apoptotic process of metanephric collecting duct development", "downregulation of apoptotic programmed cell death of metanephric collecting duct development", "down-regulation of programmed cell death by apoptosis of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "negative regulation of apoptotic process involved in metanephric collecting duct development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development. [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269814", "aliases": ["down-regulation of apoptosis of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "down regulation of apoptosis of metanephric collecting duct development"}
{"concept_id": "C3269815", "aliases": ["down-regulation of apoptotic program of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "down regulation of apoptotic program of metanephric collecting duct development"}
{"concept_id": "C3269816", "aliases": ["down-regulation of signaling (initiator) caspase activity of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "down regulation of signaling (initiator) caspase activity of metanephric collecting duct development"}
{"concept_id": "C3269817", "aliases": ["down-regulation of type I programmed cell death of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "down regulation of type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269818", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of apoptosis of metanephric collecting duct development"}
{"concept_id": "C3269819", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of apoptotic program of metanephric collecting duct development"}
{"concept_id": "C3269820", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of signaling (initiator) caspase activity of metanephric collecting duct development"}
{"concept_id": "C3269821", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269822", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis of metanephric collecting duct development"}
{"concept_id": "C3269823", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic process involved in metanephric collecting duct development"}
{"concept_id": "C3269824", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic program of metanephric collecting duct development"}
{"concept_id": "C3269825", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of signaling (initiator) caspase activity of metanephric collecting duct development"}
{"concept_id": "C3269826", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269827", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptosis of metanephric collecting duct development"}
{"concept_id": "C3269828", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptotic program of metanephric collecting duct development"}
{"concept_id": "C3269829", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of signaling (initiator) caspase activity of metanephric collecting duct development"}
{"concept_id": "C3269830", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269832", "aliases": ["activation of apoptotic process involved in metanephric collecting duct development", "activation of apoptotic program of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "activation of apoptosis of metanephric collecting duct development"}
{"concept_id": "C3269834", "aliases": [], "types": ["T043"], "canonical_name": "activation of type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269835", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptosis of metanephric collecting duct development"}
{"concept_id": "C3269836", "aliases": ["positive regulation of apoptotic process of metanephric collecting duct development", "upregulation of apoptotic program of metanephric collecting duct development", "activation of signaling (initiator) caspase activity of metanephric collecting duct development", "up-regulation of apoptotic process involved in metanephric collecting duct development", "upregulation of apoptotic process of metanephric collecting duct development", "up regulation of apoptotic cell death of metanephric collecting duct development", "up regulation of apoptotic process of metanephric collecting duct development", "positive regulation of apoptotic program of metanephric collecting duct development", "upregulation of programmed cell death by apoptosis of metanephric collecting duct development", "upregulation of apoptotic cell death of metanephric collecting duct development", "up-regulation of apoptosis of metanephric collecting duct development", "up regulation of apoptosis of metanephric collecting duct development", "up regulation of apoptotic program of metanephric collecting duct development", "activation of apoptotic cell death of metanephric collecting duct development", "positive regulation of apoptotic programmed cell death of metanephric collecting duct development", "positive regulation of programmed cell death by apoptosis of metanephric collecting duct development", "up-regulation of programmed cell death by apoptosis of metanephric collecting duct development", "up-regulation of apoptotic process of metanephric collecting duct development", "up-regulation of apoptotic cell death of metanephric collecting duct development", "up-regulation of apoptotic program of metanephric collecting duct development", "upregulation of apoptotic programmed cell death of metanephric collecting duct development", "activation of apoptotic process of metanephric collecting duct development", "up regulation of programmed cell death by apoptosis of metanephric collecting duct development", "up regulation of apoptotic process involved in metanephric collecting duct development", "upregulation of apoptotic process involved in metanephric collecting duct development", "up regulation of apoptotic programmed cell death of metanephric collecting duct development", "activation of apoptotic programmed cell death of metanephric collecting duct development", "upregulation of apoptosis of metanephric collecting duct development", "positive regulation of apoptotic cell death of metanephric collecting duct development", "activation of programmed cell death by apoptosis of metanephric collecting duct development", "up-regulation of apoptotic programmed cell death of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "positive regulation of apoptotic process involved in metanephric collecting duct development", "definition": "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development. [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269837", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of signaling (initiator) caspase activity of metanephric collecting duct development"}
{"concept_id": "C3269838", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269839", "aliases": ["up-regulation of signaling (initiator) caspase activity of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "up regulation of signaling (initiator) caspase activity of metanephric collecting duct development"}
{"concept_id": "C3269840", "aliases": ["up-regulation of type I programmed cell death of metanephric collecting duct development"], "types": ["T043"], "canonical_name": "up regulation of type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269841", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of signaling (initiator) caspase activity of metanephric collecting duct development"}
{"concept_id": "C3269842", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of type I programmed cell death of metanephric collecting duct development"}
{"concept_id": "C3269843", "aliases": ["regulation of apoptosis of metanephric nephron tubule development", "regulation of apoptotic process of metanephric nephron tubule development", "regulation of apoptotic program of metanephric nephron tubule development", "regulation of programmed cell death by apoptosis of metanephric nephron tubule development", "regulation of apoptotic cell death of metanephric nephron tubule development", "regulation of apoptotic programmed cell death of metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "regulation of apoptotic process involved in metanephric nephron tubule development", "definition": "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development. [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269844", "aliases": [], "types": ["T043"], "canonical_name": "regulation of signaling (initiator) caspase activity of metanephric nephron tubule development"}
{"concept_id": "C3269845", "aliases": [], "types": ["T043"], "canonical_name": "regulation of type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269846", "aliases": ["down regulation of apoptotic programmed cell death of metanephric nephron tubule development", "downregulation of apoptotic programmed cell death of metanephric nephron tubule development", "down-regulation of programmed cell death by apoptosis of metanephric nephron tubule development", "down-regulation of apoptotic programmed cell death of metanephric nephron tubule development", "inhibition of apoptotic cell death of metanephric nephron tubule development", "down-regulation of apoptotic process of metanephric nephron tubule development", "down regulation of apoptotic process of metanephric nephron tubule development", "negative regulation of apoptotic cell death of metanephric nephron tubule development", "inhibition of programmed cell death by apoptosis of metanephric nephron tubule development", "negative regulation of apoptotic programmed cell death of metanephric nephron tubule development", "downregulation of programmed cell death by apoptosis of metanephric nephron tubule development", "down regulation of apoptotic cell death of metanephric nephron tubule development", "downregulation of apoptotic process of metanephric nephron tubule development", "inhibition of apoptotic programmed cell death of metanephric nephron tubule development", "down regulation of apoptotic process involved in metanephric nephron tubule development", "negative regulation of programmed cell death by apoptosis of metanephric nephron tubule development", "down-regulation of apoptotic cell death of metanephric nephron tubule development", "negative regulation of apoptotic process of metanephric nephron tubule development", "inhibition of apoptotic process of metanephric nephron tubule development", "down-regulation of apoptotic process involved in metanephric nephron tubule development", "down regulation of programmed cell death by apoptosis of metanephric nephron tubule development", "downregulation of apoptotic cell death of metanephric nephron tubule development", "downregulation of apoptotic process involved in metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "negative regulation of apoptotic process involved in metanephric nephron tubule development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development. [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269847", "aliases": ["down-regulation of apoptosis of metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "down regulation of apoptosis of metanephric nephron tubule development"}
{"concept_id": "C3269848", "aliases": ["down-regulation of apoptotic program of metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "down regulation of apoptotic program of metanephric nephron tubule development"}
{"concept_id": "C3269849", "aliases": ["down-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "down regulation of signaling (initiator) caspase activity of metanephric nephron tubule development"}
{"concept_id": "C3269850", "aliases": ["down-regulation of type I programmed cell death of metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "down regulation of type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269851", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of apoptosis of metanephric nephron tubule development"}
{"concept_id": "C3269852", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of apoptotic program of metanephric nephron tubule development"}
{"concept_id": "C3269853", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of signaling (initiator) caspase activity of metanephric nephron tubule development"}
{"concept_id": "C3269854", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269855", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis of metanephric nephron tubule development"}
{"concept_id": "C3269856", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic process involved in metanephric nephron tubule development"}
{"concept_id": "C3269857", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic program of metanephric nephron tubule development"}
{"concept_id": "C3269858", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of signaling (initiator) caspase activity of metanephric nephron tubule development"}
{"concept_id": "C3269859", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269860", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptosis of metanephric nephron tubule development"}
{"concept_id": "C3269861", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptotic program of metanephric nephron tubule development"}
{"concept_id": "C3269862", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of signaling (initiator) caspase activity of metanephric nephron tubule development"}
{"concept_id": "C3269863", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269866", "aliases": [], "types": ["T043"], "canonical_name": "activation of signaling (initiator) caspase activity of metanephric nephron tubule development"}
{"concept_id": "C3269867", "aliases": [], "types": ["T043"], "canonical_name": "activation of type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269868", "aliases": ["positive regulation of programmed cell death by apoptosis of metanephric nephron tubule development", "positive regulation of apoptotic program of metanephric nephron tubule development", "upregulation of apoptotic process of metanephric nephron tubule development", "upregulation of programmed cell death by apoptosis of metanephric nephron tubule development", "up-regulation of apoptotic process involved in metanephric nephron tubule development", "activation of apoptotic program of metanephric nephron tubule development", "upregulation of apoptotic programmed cell death of metanephric nephron tubule development", "up-regulation of apoptotic programmed cell death of metanephric nephron tubule development", "up-regulation of apoptotic process of metanephric nephron tubule development", "up regulation of apoptotic process involved in metanephric nephron tubule development", "positive regulation of apoptotic cell death of metanephric nephron tubule development", "activation of apoptotic process involved in metanephric nephron tubule development", "positive regulation of apoptosis of metanephric nephron tubule development", "up regulation of apoptotic program of metanephric nephron tubule development", "up regulation of apoptotic process of metanephric nephron tubule development", "up-regulation of apoptotic program of metanephric nephron tubule development", "up regulation of apoptotic programmed cell death of metanephric nephron tubule development", "positive regulation of apoptotic programmed cell death of metanephric nephron tubule development", "up regulation of apoptotic cell death of metanephric nephron tubule development", "activation of programmed cell death by apoptosis of metanephric nephron tubule development", "activation of apoptotic programmed cell death of metanephric nephron tubule development", "activation of apoptotic cell death of metanephric nephron tubule development", "upregulation of apoptosis of metanephric nephron tubule development", "activation of apoptotic process of metanephric nephron tubule development", "upregulation of apoptotic process involved in metanephric nephron tubule development", "up-regulation of apoptotic cell death of metanephric nephron tubule development", "positive regulation of apoptotic process of metanephric nephron tubule development", "upregulation of apoptotic cell death of metanephric nephron tubule development", "activation of apoptosis of metanephric nephron tubule development", "up-regulation of programmed cell death by apoptosis of metanephric nephron tubule development", "upregulation of apoptotic program of metanephric nephron tubule development", "up-regulation of apoptosis of metanephric nephron tubule development", "up regulation of programmed cell death by apoptosis of metanephric nephron tubule development", "up regulation of apoptosis of metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "positive regulation of apoptotic process involved in metanephric nephron tubule development", "definition": "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development. [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]"}
{"concept_id": "C3269869", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of signaling (initiator) caspase activity of metanephric nephron tubule development"}
{"concept_id": "C3269870", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269871", "aliases": ["up-regulation of type I programmed cell death of metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "up regulation of type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269872", "aliases": ["up-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development", "upregulation of signaling (initiator) caspase activity of metanephric nephron tubule development"], "types": ["T043"], "canonical_name": "up regulation of signaling (initiator) caspase activity of metanephric nephron tubule development"}
{"concept_id": "C3269873", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of type I programmed cell death of metanephric nephron tubule development"}
{"concept_id": "C3269874", "aliases": ["semaphorin-plexin signaling pathway of bone trabecula morphogenesis", "semaphorin-plexin signalling pathway of bone trabecula morphogenesis"], "types": ["T044"], "canonical_name": "semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis", "definition": "Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269875", "aliases": ["regulation of beta-amyloid clearance"], "types": ["T038"], "canonical_name": "regulation of amyloid-beta clearance", "definition": "Any process that modulates the frequency, rate or extent of amyloid-beta clearance. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269876", "aliases": ["negative regulation of beta-amyloid clearance", "down regulation of beta-amyloid clearance", "downregulation of beta-amyloid clearance", "down-regulation of beta-amyloid clearance"], "types": ["T038"], "canonical_name": "negative regulation of amyloid-beta clearance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269877", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of beta-amyloid clearance"}
{"concept_id": "C3269878", "aliases": ["up regulation of beta-amyloid clearance", "positive regulation of beta-amyloid clearance", "upregulation of beta-amyloid clearance", "up-regulation of beta-amyloid clearance"], "types": ["T038"], "canonical_name": "positive regulation of amyloid-beta clearance", "definition": "Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269879", "aliases": [], "types": ["T038"], "canonical_name": "activation of beta-amyloid clearance"}
{"concept_id": "C3269882", "aliases": ["regulation of NALP3 inflammasome complex assembly"], "types": ["T043"], "canonical_name": "regulation of NLRP3 inflammasome complex assembly", "definition": "Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly. [GOC:TermGenie]"}
{"concept_id": "C3269883", "aliases": [], "types": ["T043"], "canonical_name": "regulation of NLRP3 inflammasome activation"}
{"concept_id": "C3269884", "aliases": ["down-regulation of NALP3 inflammasome complex assembly", "downregulation of NALP3 inflammasome complex assembly", "inhibition of NALP3 inflammasome complex assembly", "down-regulation of NLRP3 inflammasome complex assembly", "down regulation of NLRP3 inflammasome complex assembly", "downregulation of NLRP3 inflammasome complex assembly", "down regulation of NALP3 inflammasome complex assembly", "inhibition of NLRP3 inflammasome complex assembly", "negative regulation of NALP3 inflammasome complex assembly"], "types": ["T043"], "canonical_name": "negative regulation of NLRP3 inflammasome complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly. [GOC:TermGenie]"}
{"concept_id": "C3269885", "aliases": ["upregulation of NLRP3 inflammasome complex assembly", "up regulation of NLRP3 inflammasome complex assembly", "upregulation of NALP3 inflammasome complex assembly", "up-regulation of NLRP3 inflammasome complex assembly", "up-regulation of NALP3 inflammasome complex assembly", "activation of NLRP3 inflammasome complex assembly", "positive regulation of NALP3 inflammasome complex assembly", "activation of NALP3 inflammasome complex assembly", "up regulation of NALP3 inflammasome complex assembly"], "types": ["T043"], "canonical_name": "positive regulation of NLRP3 inflammasome complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly. [GOC:TermGenie]"}
{"concept_id": "C3269886", "aliases": ["upregulation of NLRP3 inflammasome activation", "positive regulation of NLRP3 inflammasome activation"], "types": ["T043"], "canonical_name": "activation of NLRP3 inflammasome activation"}
{"concept_id": "C3269887", "aliases": ["up-regulation of NLRP3 inflammasome activation"], "types": ["T043"], "canonical_name": "up regulation of NLRP3 inflammasome activation"}
{"concept_id": "C3269888", "aliases": [], "types": ["T043"], "canonical_name": "regulation of single-species biofilm formation in or on host organism", "definition": "Any process that modulates the frequency, rate or extent of single-species biofilm formation in or on host organism. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269890", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of single-species biofilm formation in or on host organism"}
{"concept_id": "C3269891", "aliases": ["upregulation of single-species biofilm formation in or on host organism", "up regulation of single-species biofilm formation in or on host organism", "up-regulation of single-species biofilm formation in or on host organism"], "types": ["T038"], "canonical_name": "positive regulation of single-species biofilm formation in or on host organism", "definition": "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation in or on host organism. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269892", "aliases": [], "types": ["T038"], "canonical_name": "activation of single-species biofilm formation in or on host organism"}
{"concept_id": "C3269893", "aliases": [], "types": ["T043"], "canonical_name": "regulation of single-species biofilm formation on inanimate substrate", "definition": "Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269895", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of single-species biofilm formation on inanimate substrate"}
{"concept_id": "C3269896", "aliases": ["upregulation of single-species biofilm formation on inanimate substrate", "up regulation of single-species biofilm formation on inanimate substrate", "up-regulation of single-species biofilm formation on inanimate substrate"], "types": ["T038"], "canonical_name": "positive regulation of single-species biofilm formation on inanimate substrate", "definition": "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269897", "aliases": [], "types": ["T038"], "canonical_name": "activation of single-species biofilm formation on inanimate substrate"}
{"concept_id": "C3269898", "aliases": ["regulation of Kit signalling pathway", "regulation of stem cell factor signaling pathway", "regulation of stem cell factor receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of Kit signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of Kit signaling pathway. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3269899", "aliases": ["down regulation of stem cell factor signaling pathway", "down-regulation of Kit signaling pathway", "downregulation of Kit signaling pathway", "downregulation of stem cell factor receptor signaling pathway", "inhibition of stem cell factor receptor signaling pathway", "negative regulation of stem cell factor signaling pathway", "down-regulation of stem cell factor receptor signaling pathway", "down regulation of Kit signaling pathway", "down-regulation of stem cell factor signaling pathway", "negative regulation of Kit signalling pathway", "negative regulation of stem cell factor receptor signaling pathway", "inhibition of stem cell factor signaling pathway", "down regulation of stem cell factor receptor signaling pathway", "downregulation of stem cell factor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of Kit signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Kit signaling pathway. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3269900", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Kit signaling pathway"}
{"concept_id": "C3269903", "aliases": ["up regulation of induction of conjugation with cellular fusion", "upregulation of induction of conjugation with cellular fusion", "up-regulation of induction of conjugation with cellular fusion"], "types": ["T038"], "canonical_name": "positive regulation of induction of conjugation with cellular fusion", "definition": "Any process that activates or increases the frequency, rate or extent of induction of conjugation with cellular fusion. [GOC:TermGenie]"}
{"concept_id": "C3269904", "aliases": ["regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway"], "types": ["T044"], "canonical_name": "regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of regulation of metanephric mesenchymal cell migration, by platelet-derived growth factor receptor-beta signaling pathway. [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:19019919]"}
{"concept_id": "C3269905", "aliases": [], "types": ["T044"], "canonical_name": "regulation of metanephric mesenchyme chemotaxis by platelet-derived growth factor receptor-beta signaling pathway"}
{"concept_id": "C3269906", "aliases": [], "types": ["T038"], "canonical_name": "regulation of phenotypic switching", "definition": "Any process that modulates the frequency, rate or extent of phenotypic switching. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269907", "aliases": [], "types": ["T038"], "canonical_name": "regulation of phenotypic dimorphism"}
{"concept_id": "C3269909", "aliases": ["down-regulation of phenotypic dimorphism"], "types": ["T038"], "canonical_name": "down regulation of phenotypic dimorphism"}
{"concept_id": "C3269910", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of phenotypic dimorphism"}
{"concept_id": "C3269911", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of phenotypic dimorphism"}
{"concept_id": "C3269912", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of phenotypic switching"}
{"concept_id": "C3269913", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of phenotypic dimorphism"}
{"concept_id": "C3269914", "aliases": ["upregulation of phenotypic switching", "up regulation of phenotypic switching", "up-regulation of phenotypic switching"], "types": ["T038"], "canonical_name": "positive regulation of phenotypic switching", "definition": "Any process that activates or increases the frequency, rate or extent of phenotypic switching. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3269915", "aliases": [], "types": ["T038"], "canonical_name": "activation of phenotypic dimorphism"}
{"concept_id": "C3269916", "aliases": [], "types": ["T038"], "canonical_name": "activation of phenotypic switching"}
{"concept_id": "C3269917", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of phenotypic dimorphism"}
{"concept_id": "C3269918", "aliases": ["up-regulation of phenotypic dimorphism"], "types": ["T038"], "canonical_name": "up regulation of phenotypic dimorphism"}
{"concept_id": "C3269919", "aliases": [], "types": ["T038"], "canonical_name": "upregulation of phenotypic dimorphism"}
{"concept_id": "C3269920", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle endocytosis", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269921", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle retrieval"}
{"concept_id": "C3269922", "aliases": ["downregulation of synaptic vesicle endocytosis", "negative regulation of synaptic vesicle retrieval", "down regulation of synaptic vesicle endocytosis", "down-regulation of synaptic vesicle endocytosis"], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle endocytosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle endocytosis. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269923", "aliases": ["up regulation of synaptic vesicle endocytosis", "up-regulation of synaptic vesicle endocytosis", "upregulation of synaptic vesicle endocytosis"], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle endocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3269924", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptic vesicle endocytosis"}
{"concept_id": "C3269925", "aliases": ["up-regulation of synaptic vesicle retrieval"], "types": ["T043"], "canonical_name": "up regulation of synaptic vesicle retrieval"}
{"concept_id": "C3269926", "aliases": ["upregulation of synaptic vesicle retrieval", "positive regulation of synaptic vesicle retrieval"], "types": ["T043"], "canonical_name": "activation of synaptic vesicle retrieval"}
{"concept_id": "C3269928", "aliases": [], "types": ["T043"], "canonical_name": "activation of IFIH1 signaling pathway"}
{"concept_id": "C3269929", "aliases": [], "types": ["T043"], "canonical_name": "activation of MDA-5 signaling pathway"}
{"concept_id": "C3269930", "aliases": [], "types": ["T043"], "canonical_name": "activation of MDA5 signaling pathway"}
{"concept_id": "C3269931", "aliases": [], "types": ["T043"], "canonical_name": "activation of melanoma differentiation-associated gene 5 signaling pathway"}
{"concept_id": "C3269932", "aliases": ["upregulation of IFIH1 signaling pathway", "positive regulation of IFIH1 signaling pathway", "up regulation of MDA-5 signaling pathway", "up-regulation of IFIH1 signaling pathway", "up-regulation of melanoma differentiation-associated gene 5 signaling pathway", "upregulation of melanoma differentiation-associated gene 5 signaling pathway", "up regulation of IFIH1 signaling pathway", "positive regulation of melanoma differentiation-associated gene 5 signaling pathway", "positive regulation of MDA5 signaling pathway", "upregulation of MDA-5 signaling pathway", "up regulation of melanoma differentiation-associated gene 5 signaling pathway", "positive regulation of MDA-5 signalling pathway", "up-regulation of MDA-5 signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of MDA-5 signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway. [GOC:TermGenie]"}
{"concept_id": "C3269933", "aliases": ["up-regulation of MDA5 signaling pathway"], "types": ["T043"], "canonical_name": "up regulation of MDA5 signaling pathway"}
{"concept_id": "C3269934", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of MDA5 signaling pathway"}
{"concept_id": "C3269936", "aliases": [], "types": ["T043"], "canonical_name": "activation of DDX58 signaling pathway"}
{"concept_id": "C3269937", "aliases": [], "types": ["T043"], "canonical_name": "activation of retinoic acid inducible gene I signaling pathway"}
{"concept_id": "C3269938", "aliases": [], "types": ["T043"], "canonical_name": "activation of RIG-I signaling pathway"}
{"concept_id": "C3269939", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic translational elongation", "definition": "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation. [GOC:TermGenie]"}
{"concept_id": "C3269940", "aliases": ["down regulation of cytoplasmic translational elongation", "down-regulation of cytoplasmic translational elongation", "downregulation of cytoplasmic translational elongation"], "types": ["T043"], "canonical_name": "negative regulation of cytoplasmic translational elongation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation. [GOC:TermGenie]"}
{"concept_id": "C3269941", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytoplasmic translational elongation"}
{"concept_id": "C3269942", "aliases": ["up-regulation of cytoplasmic translational elongation", "upregulation of cytoplasmic translational elongation", "up regulation of cytoplasmic translational elongation"], "types": ["T043"], "canonical_name": "positive regulation of cytoplasmic translational elongation", "definition": "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation. [GOC:TermGenie]"}
{"concept_id": "C3269943", "aliases": [], "types": ["T043"], "canonical_name": "activation of cytoplasmic translational elongation"}
{"concept_id": "C3269944", "aliases": ["regulation of beta1 adrenoceptor"], "types": ["T043"], "canonical_name": "regulation of beta1-adrenergic receptor activity", "definition": "Any process that modulates the frequency, rate or extent of beta1-adrenergic receptor activity. [GOC:TermGenie]"}
{"concept_id": "C3269947", "aliases": ["activation of beta1 adrenoceptor", "up regulation of beta1-adrenergic receptor activity", "up regulation of beta1 adrenoceptor", "upregulation of beta1 adrenoceptor", "up-regulation of beta1 adrenoceptor", "upregulation of beta1-adrenergic receptor activity", "up-regulation of beta1-adrenergic receptor activity", "positive regulation of beta1 adrenoceptor", "activation of beta1-adrenergic receptor activity"], "types": ["T044"], "canonical_name": "positive regulation of beta1-adrenergic receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of beta1-adrenergic receptor activity. [GOC:TermGenie]"}
{"concept_id": "C3269949", "aliases": [], "types": ["T044"], "canonical_name": "regulation of PB1 proteins"}
{"concept_id": "C3269950", "aliases": [], "types": ["T044"], "canonical_name": "regulation of PB2 proteins"}
{"concept_id": "C3269951", "aliases": [], "types": ["T045"], "canonical_name": "regulation of phage f2 replicase"}
{"concept_id": "C3269952", "aliases": [], "types": ["T044"], "canonical_name": "regulation of polymerase L"}
{"concept_id": "C3269953", "aliases": ["regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "regulation of RDRP", "regulation of ribonucleic acid replicase activity", "regulation of RNA-dependent RNA polymerase activity", "regulation of RNA-dependent RNA replicase activity", "regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "regulation of RNA nucleotidyltransferase (RNA-directed) activity", "regulation of RNA-directed RNA polymerase activity", "regulation of RNA replicase activity", "regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "regulation of RNA-dependent ribonucleate nucleotidyltransferase activity", "regulation of ribonucleic replicase activity", "regulation of 3D polymerase activity", "regulation of Q-beta replicase activity"], "types": ["T044"], "canonical_name": "regulation of RNA-directed 5'-3' RNA polymerase activity", "definition": "Any process that modulates the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. [GOC:pf, GOC:TermGenie]"}
{"concept_id": "C3269954", "aliases": ["regulation of ribonucleic synthetase activity"], "types": ["T045"], "canonical_name": "regulation of RNA synthetase activity"}
{"concept_id": "C3269955", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcriptase"}
{"concept_id": "C3269956", "aliases": ["inhibition of ribonucleic acid-dependent ribonucleic acid polymerase activity", "down-regulation of RNA-dependent RNA polymerase activity", "down regulation of RNA-dependent RNA replicase activity", "down-regulation of RNA-dependent RNA replicase activity", "negative regulation of ribonucleic replicase activity", "downregulation of RNA-dependent RNA polymerase activity", "negative regulation of Q-beta replicase activity", "downregulation of RNA-directed RNA polymerase activity", "down regulation of Q-beta replicase activity", "down regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "inhibition of RNA replicase activity", "downregulation of Q-beta replicase activity", "down-regulation of ribonucleic replicase activity", "down-regulation of 3D polymerase activity", "negative regulation of RNA nucleotidyltransferase (RNA-directed) activity", "down-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "downregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "downregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "negative regulation of RNA-dependent RNA replicase activity", "down-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "inhibition of Q-beta replicase activity", "negative regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "down regulation of ribonucleic acid replicase activity", "negative regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "inhibition of 3D polymerase activity", "negative regulation of 3D polymerase activity", "inhibition of ribonucleic replicase activity", "negative regulation of RNA replicase activity", "down-regulation of Q-beta replicase activity", "negative regulation of ribonucleic acid replicase activity", "negative regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "down regulation of RNA-dependent ribonucleate nucleotidyltransferase activity", "downregulation of RNA replicase activity", "down regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "downregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "down-regulation of RNA nucleotidyltransferase (RNA-directed) activity", "inhibition of RNA-dependent RNA polymerase activity", "inhibition of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "negative regulation of RNA-dependent ribonucleate nucleotidyltransferase activity", "down regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "inhibition of RNA-dependent RNA replicase activity", "down regulation of 3D polymerase activity", "down-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "downregulation of RNA-dependent RNA replicase activity", "down-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity", "down regulation of ribonucleic replicase activity", "inhibition of RNA nucleotidyltransferase (RNA-directed) activity", "downregulation of RNA-dependent ribonucleate nucleotidyltransferase activity", "down-regulation of RNA replicase activity", "negative regulation of RNA-directed RNA polymerase activity", "down-regulation of RNA-directed RNA polymerase activity", "down regulation of RNA-dependent RNA polymerase activity", "down-regulation of ribonucleic acid replicase activity", "downregulation of RNA nucleotidyltransferase (RNA-directed) activity", "down regulation of RNA-directed RNA polymerase activity", "down regulation of RNA replicase activity", "inhibition of ribonucleic acid replicase activity", "inhibition of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "inhibition of RNA-dependent ribonucleate nucleotidyltransferase activity", "downregulation of 3D polymerase activity", "down regulation of RNA nucleotidyltransferase (RNA-directed) activity", "downregulation of ribonucleic acid replicase activity", "negative regulation of RNA-dependent RNA polymerase activity", "downregulation of ribonucleic replicase activity"], "types": ["T044"], "canonical_name": "negative regulation of RNA-directed 5'-3' RNA polymerase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. [GOC:pf, GOC:TermGenie]"}
{"concept_id": "C3269957", "aliases": ["down-regulation of PB1 proteins"], "types": ["T044"], "canonical_name": "down regulation of PB1 proteins"}
{"concept_id": "C3269958", "aliases": ["down-regulation of PB2 proteins", "downregulation of PB2 proteins"], "types": ["T044"], "canonical_name": "down regulation of PB2 proteins"}
{"concept_id": "C3269959", "aliases": ["down-regulation of phage f2 replicase"], "types": ["T044"], "canonical_name": "down regulation of phage f2 replicase"}
{"concept_id": "C3269960", "aliases": ["down-regulation of polymerase L"], "types": ["T044"], "canonical_name": "down regulation of polymerase L"}
{"concept_id": "C3269961", "aliases": ["down-regulation of RDRP"], "types": ["T044"], "canonical_name": "down regulation of RDRP"}
{"concept_id": "C3269962", "aliases": ["down-regulation of ribonucleic synthetase activity"], "types": ["T044"], "canonical_name": "down regulation of ribonucleic synthetase activity"}
{"concept_id": "C3269963", "aliases": ["down-regulation of transcriptase"], "types": ["T044"], "canonical_name": "down regulation of transcriptase"}
{"concept_id": "C3269964", "aliases": ["down-regulation of RNA synthetase activity", "downregulation of RNA synthetase activity"], "types": ["T044"], "canonical_name": "down regulation of RNA synthetase activity"}
{"concept_id": "C3269965", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of PB1 proteins"}
{"concept_id": "C3269966", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of phage f2 replicase"}
{"concept_id": "C3269967", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of polymerase L"}
{"concept_id": "C3269968", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of RDRP"}
{"concept_id": "C3269969", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of ribonucleic synthetase activity"}
{"concept_id": "C3269970", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of transcriptase"}
{"concept_id": "C3269971", "aliases": ["negative regulation of PB1 proteins"], "types": ["T044"], "canonical_name": "inhibition of PB1 proteins"}
{"concept_id": "C3269972", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of PB2 proteins"}
{"concept_id": "C3269973", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phage f2 replicase"}
{"concept_id": "C3269974", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polymerase L"}
{"concept_id": "C3269975", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RDRP"}
{"concept_id": "C3269976", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ribonucleic synthetase activity"}
{"concept_id": "C3269977", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA synthetase activity"}
{"concept_id": "C3269978", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA-directed RNA polymerase activity"}
{"concept_id": "C3269979", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of transcriptase"}
{"concept_id": "C3269980", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of PB2 proteins"}
{"concept_id": "C3269981", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phage f2 replicase"}
{"concept_id": "C3269982", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of polymerase L"}
{"concept_id": "C3269983", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of RDRP"}
{"concept_id": "C3269984", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ribonucleic synthetase activity"}
{"concept_id": "C3269985", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of RNA synthetase activity"}
{"concept_id": "C3269986", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of transcriptase"}
{"concept_id": "C3269987", "aliases": ["positive regulation of 3D polymerase activity", "positive regulation of Q-beta replicase activity", "up-regulation of RNA nucleotidyltransferase (RNA-directed) activity", "up regulation of RNA replicase activity", "upregulation of Q-beta replicase activity", "up-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity", "positive regulation of RNA nucleotidyltransferase (RNA-directed) activity", "up-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "upregulation of ribonucleic replicase activity", "up-regulation of RNA-dependent RNA replicase activity", "up regulation of RNA nucleotidyltransferase (RNA-directed) activity", "up-regulation of RNA replicase activity", "positive regulation of RNA-dependent RNA replicase activity", "up regulation of 3D polymerase activity", "activation of RNA-dependent ribonucleate nucleotidyltransferase activity", "activation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "activation of RNA-dependent RNA polymerase activity", "activation of RNA-dependent RNA replicase activity", "up-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "upregulation of RNA-dependent ribonucleate nucleotidyltransferase activity", "upregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "activation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "upregulation of RNA-directed RNA polymerase activity", "up regulation of RNA-dependent RNA polymerase activity", "activation of 3D polymerase activity", "up-regulation of ribonucleic replicase activity", "up-regulation of Q-beta replicase activity", "up-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "activation of RNA nucleotidyltransferase (RNA-directed) activity", "up regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "activation of Q-beta replicase activity", "up regulation of RNA-dependent ribonucleate nucleotidyltransferase activity", "upregulation of RNA nucleotidyltransferase (RNA-directed) activity", "up-regulation of RNA-dependent RNA polymerase activity", "up regulation of RNA-directed RNA polymerase activity", "upregulation of RNA replicase activity", "positive regulation of RNA-directed RNA polymerase activity", "upregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "positive regulation of ribonucleic replicase activity", "positive regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity", "upregulation of ribonucleic acid replicase activity", "up-regulation of RNA-directed RNA polymerase activity", "up-regulation of ribonucleic acid replicase activity", "upregulation of RNA-dependent RNA polymerase activity", "positive regulation of RNA-dependent RNA polymerase activity", "positive regulation of RNA-dependent ribonucleate nucleotidyltransferase activity", "up-regulation of 3D polymerase activity", "up regulation of RNA-dependent RNA replicase activity", "up regulation of Q-beta replicase activity", "activation of RNA replicase activity", "upregulation of RNA-dependent RNA replicase activity", "up regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "upregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "positive regulation of ribonucleic acid replicase activity", "up regulation of ribonucleic acid replicase activity", "up regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "activation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "upregulation of 3D polymerase activity", "activation of ribonucleic acid replicase activity", "up regulation of ribonucleic replicase activity", "positive regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity", "positive regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)", "activation of ribonucleic replicase activity", "positive regulation of RNA replicase activity"], "types": ["T045"], "canonical_name": "positive regulation of RNA-directed 5'-3' RNA polymerase activity", "definition": "Any process that activates or increases the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. [GOC:pf, GOC:TermGenie]"}
{"concept_id": "C3269988", "aliases": [], "types": ["T044"], "canonical_name": "activation of PB1 proteins"}
{"concept_id": "C3269989", "aliases": [], "types": ["T045"], "canonical_name": "activation of PB2 proteins"}
{"concept_id": "C3269990", "aliases": [], "types": ["T044"], "canonical_name": "activation of phage f2 replicase"}
{"concept_id": "C3269991", "aliases": [], "types": ["T045"], "canonical_name": "activation of polymerase L"}
{"concept_id": "C3269992", "aliases": [], "types": ["T045"], "canonical_name": "activation of RDRP"}
{"concept_id": "C3269993", "aliases": [], "types": ["T045"], "canonical_name": "activation of ribonucleic synthetase activity"}
{"concept_id": "C3269994", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA synthetase activity"}
{"concept_id": "C3269995", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA-directed RNA polymerase activity"}
{"concept_id": "C3269996", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcriptase"}
{"concept_id": "C3269997", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of PB1 proteins"}
{"concept_id": "C3269998", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of PB2 proteins"}
{"concept_id": "C3269999", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of phage f2 replicase"}
{"concept_id": "C3270000", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of polymerase L"}
{"concept_id": "C3270001", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of RDRP"}
{"concept_id": "C3270002", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of ribonucleic synthetase activity"}
{"concept_id": "C3270003", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of RNA synthetase activity"}
{"concept_id": "C3270004", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcriptase"}
{"concept_id": "C3270005", "aliases": ["up-regulation of PB1 proteins"], "types": ["T044"], "canonical_name": "up regulation of PB1 proteins"}
{"concept_id": "C3270006", "aliases": ["up-regulation of phage f2 replicase"], "types": ["T044"], "canonical_name": "up regulation of phage f2 replicase"}
{"concept_id": "C3270007", "aliases": ["up-regulation of polymerase L"], "types": ["T044"], "canonical_name": "up regulation of polymerase L"}
{"concept_id": "C3270008", "aliases": ["up-regulation of RDRP"], "types": ["T044"], "canonical_name": "up regulation of RDRP"}
{"concept_id": "C3270009", "aliases": ["up-regulation of ribonucleic synthetase activity"], "types": ["T044"], "canonical_name": "up regulation of ribonucleic synthetase activity"}
{"concept_id": "C3270010", "aliases": ["up-regulation of transcriptase"], "types": ["T044"], "canonical_name": "up regulation of transcriptase"}
{"concept_id": "C3270011", "aliases": ["upregulation of RNA synthetase activity", "up-regulation of RNA synthetase activity"], "types": ["T045"], "canonical_name": "up regulation of RNA synthetase activity"}
{"concept_id": "C3270012", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of PB1 proteins"}
{"concept_id": "C3270013", "aliases": ["upregulation of PB2 proteins", "up-regulation of PB2 proteins"], "types": ["T044"], "canonical_name": "up regulation of PB2 proteins"}
{"concept_id": "C3270014", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of phage f2 replicase"}
{"concept_id": "C3270015", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of polymerase L"}
{"concept_id": "C3270016", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of RDRP"}
{"concept_id": "C3270017", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of ribonucleic synthetase activity"}
{"concept_id": "C3270018", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of transcriptase"}
{"concept_id": "C3270019", "aliases": ["regulation of DNA-dependent DNA polymerase activity", "regulation of DNA nucleotidyltransferase (DNA-directed) activity", "regulation of DNA replicase activity", "regulation of DNA duplicase activity", "regulation of deoxyribonucleic duplicase activity", "regulation of deoxyribonucleic acid duplicase activity", "regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity"], "types": ["T045"], "canonical_name": "regulation of DNA-directed DNA polymerase activity", "definition": "Any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity. [GOC:TermGenie]"}
{"concept_id": "C3270020", "aliases": [], "types": ["T045"], "canonical_name": "regulation of alpha DNA polymerase activity"}
{"concept_id": "C3270021", "aliases": [], "types": ["T045"], "canonical_name": "regulation of beta DNA polymerase activity"}
{"concept_id": "C3270022", "aliases": [], "types": ["T045"], "canonical_name": "regulation of delta DNA polymerase activity"}
{"concept_id": "C3270023", "aliases": [], "types": ["T045"], "canonical_name": "regulation of deoxyribonucleic polymerase I"}
{"concept_id": "C3270024", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA polymerase alpha"}
{"concept_id": "C3270025", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA polymerase beta"}
{"concept_id": "C3270026", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA polymerase gamma"}
{"concept_id": "C3270027", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA polymerase I"}
{"concept_id": "C3270028", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA polymerase II"}
{"concept_id": "C3270029", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA polymerase III"}
{"concept_id": "C3270030", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA polymerase V activity"}
{"concept_id": "C3270031", "aliases": [], "types": ["T045"], "canonical_name": "regulation of duplicase"}
{"concept_id": "C3270032", "aliases": [], "types": ["T045"], "canonical_name": "regulation of epsilon DNA polymerase activity"}
{"concept_id": "C3270033", "aliases": [], "types": ["T045"], "canonical_name": "regulation of eta DNA polymerase activity"}
{"concept_id": "C3270034", "aliases": [], "types": ["T045"], "canonical_name": "regulation of gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C3270035", "aliases": [], "types": ["T045"], "canonical_name": "regulation of iota DNA polymerase activity"}
{"concept_id": "C3270036", "aliases": [], "types": ["T045"], "canonical_name": "regulation of kappa DNA polymerase activity"}
{"concept_id": "C3270037", "aliases": [], "types": ["T045"], "canonical_name": "regulation of Klenow fragment"}
{"concept_id": "C3270038", "aliases": [], "types": ["T045"], "canonical_name": "regulation of lambda DNA polymerase activity"}
{"concept_id": "C3270039", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mu DNA polymerase activity"}
{"concept_id": "C3270040", "aliases": [], "types": ["T045"], "canonical_name": "regulation of nu DNA polymerase activity"}
{"concept_id": "C3270041", "aliases": [], "types": ["T045"], "canonical_name": "regulation of sequenase"}
{"concept_id": "C3270042", "aliases": [], "types": ["T045"], "canonical_name": "regulation of sigma DNA polymerase activity"}
{"concept_id": "C3270043", "aliases": [], "types": ["T045"], "canonical_name": "regulation of Taq DNA polymerase"}
{"concept_id": "C3270044", "aliases": [], "types": ["T045"], "canonical_name": "regulation of Taq Pol I"}
{"concept_id": "C3270045", "aliases": [], "types": ["T045"], "canonical_name": "regulation of Tca DNA polymerase"}
{"concept_id": "C3270046", "aliases": [], "types": ["T045"], "canonical_name": "regulation of theta DNA polymerase activity"}
{"concept_id": "C3270047", "aliases": [], "types": ["T045"], "canonical_name": "regulation of zeta DNA polymerase activity"}
{"concept_id": "C3270048", "aliases": ["down regulation of DNA replicase activity", "downregulation of DNA duplicase activity", "inhibition of DNA-dependent DNA polymerase activity", "inhibition of deoxyribonucleic acid duplicase activity", "down regulation of DNA-dependent DNA polymerase activity", "down-regulation of deoxyribonucleic acid duplicase activity", "downregulation of DNA-dependent DNA polymerase activity", "downregulation of DNA replicase activity", "down regulation of DNA-directed DNA polymerase activity", "downregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "negative regulation of DNA duplicase activity", "down-regulation of DNA-directed DNA polymerase activity", "down-regulation of DNA replicase activity", "inhibition of DNA duplicase activity", "down-regulation of DNA-dependent DNA polymerase activity", "negative regulation of DNA nucleotidyltransferase (DNA-directed) activity", "down regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "negative regulation of DNA-dependent DNA polymerase activity", "inhibition of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "inhibition of deoxyribonucleic duplicase activity", "down-regulation of deoxyribonucleic duplicase activity", "negative regulation of deoxyribonucleic duplicase activity", "downregulation of deoxyribonucleic acid duplicase activity", "inhibition of DNA nucleotidyltransferase (DNA-directed) activity", "down-regulation of DNA nucleotidyltransferase (DNA-directed) activity", "down regulation of DNA duplicase activity", "downregulation of DNA nucleotidyltransferase (DNA-directed) activity", "down-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "down regulation of DNA nucleotidyltransferase (DNA-directed) activity", "down-regulation of DNA duplicase activity", "downregulation of deoxyribonucleic duplicase activity", "negative regulation of deoxyribonucleic acid duplicase activity", "negative regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "inhibition of DNA replicase activity", "downregulation of DNA-directed DNA polymerase activity", "down regulation of deoxyribonucleic duplicase activity", "negative regulation of DNA replicase activity", "down regulation of deoxyribonucleic acid duplicase activity"], "types": ["T044"], "canonical_name": "negative regulation of DNA-directed DNA polymerase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-directed DNA polymerase activity. [GOC:TermGenie]"}
{"concept_id": "C3270049", "aliases": ["down-regulation of alpha DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of alpha DNA polymerase activity"}
{"concept_id": "C3270050", "aliases": ["down-regulation of beta DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of beta DNA polymerase activity"}
{"concept_id": "C3270051", "aliases": ["down-regulation of delta DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of delta DNA polymerase activity"}
{"concept_id": "C3270052", "aliases": ["down-regulation of deoxyribonucleic polymerase I"], "types": ["T044"], "canonical_name": "down regulation of deoxyribonucleic polymerase I"}
{"concept_id": "C3270053", "aliases": ["down-regulation of DNA polymerase alpha"], "types": ["T044"], "canonical_name": "down regulation of DNA polymerase alpha"}
{"concept_id": "C3270054", "aliases": ["down-regulation of DNA polymerase beta"], "types": ["T044"], "canonical_name": "down regulation of DNA polymerase beta"}
{"concept_id": "C3270055", "aliases": ["down-regulation of DNA polymerase gamma"], "types": ["T044"], "canonical_name": "down regulation of DNA polymerase gamma"}
{"concept_id": "C3270056", "aliases": ["downregulation of DNA polymerase I", "down-regulation of DNA polymerase I"], "types": ["T044"], "canonical_name": "down regulation of DNA polymerase I"}
{"concept_id": "C3270057", "aliases": ["down-regulation of DNA polymerase II"], "types": ["T044"], "canonical_name": "down regulation of DNA polymerase II"}
{"concept_id": "C3270058", "aliases": ["down-regulation of DNA polymerase III"], "types": ["T044"], "canonical_name": "down regulation of DNA polymerase III"}
{"concept_id": "C3270059", "aliases": ["down-regulation of DNA polymerase V activity"], "types": ["T044"], "canonical_name": "down regulation of DNA polymerase V activity"}
{"concept_id": "C3270060", "aliases": ["down-regulation of eta DNA polymerase activity", "downregulation of eta DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of eta DNA polymerase activity"}
{"concept_id": "C3270061", "aliases": ["down-regulation of gamma DNA-directed DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C3270062", "aliases": ["down-regulation of iota DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of iota DNA polymerase activity"}
{"concept_id": "C3270063", "aliases": ["down-regulation of kappa DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of kappa DNA polymerase activity"}
{"concept_id": "C3270064", "aliases": ["down-regulation of Klenow fragment"], "types": ["T044"], "canonical_name": "down regulation of Klenow fragment"}
{"concept_id": "C3270065", "aliases": ["down-regulation of lambda DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of lambda DNA polymerase activity"}
{"concept_id": "C3270066", "aliases": ["down-regulation of mu DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of mu DNA polymerase activity"}
{"concept_id": "C3270067", "aliases": ["down-regulation of nu DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of nu DNA polymerase activity"}
{"concept_id": "C3270068", "aliases": ["down-regulation of sequenase"], "types": ["T044"], "canonical_name": "down regulation of sequenase"}
{"concept_id": "C3270069", "aliases": ["down-regulation of sigma DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of sigma DNA polymerase activity"}
{"concept_id": "C3270070", "aliases": ["down-regulation of Taq DNA polymerase"], "types": ["T044"], "canonical_name": "down regulation of Taq DNA polymerase"}
{"concept_id": "C3270071", "aliases": ["down-regulation of Taq Pol I"], "types": ["T044"], "canonical_name": "down regulation of Taq Pol I"}
{"concept_id": "C3270072", "aliases": ["down-regulation of Tca DNA polymerase"], "types": ["T044"], "canonical_name": "down regulation of Tca DNA polymerase"}
{"concept_id": "C3270073", "aliases": ["down-regulation of theta DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of theta DNA polymerase activity"}
{"concept_id": "C3270074", "aliases": ["down-regulation of zeta DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of zeta DNA polymerase activity"}
{"concept_id": "C3270075", "aliases": ["negative regulation of epsilon DNA polymerase activity", "downregulation of epsilon DNA polymerase activity", "inhibition of epsilon DNA polymerase activity", "down-regulation of epsilon DNA polymerase activity"], "types": ["T044"], "canonical_name": "down regulation of epsilon DNA polymerase activity"}
{"concept_id": "C3270076", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of alpha DNA polymerase activity"}
{"concept_id": "C3270077", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of beta DNA polymerase activity"}
{"concept_id": "C3270078", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of delta DNA polymerase activity"}
{"concept_id": "C3270079", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of deoxyribonucleic polymerase I"}
{"concept_id": "C3270080", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of DNA polymerase alpha"}
{"concept_id": "C3270081", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of DNA polymerase beta"}
{"concept_id": "C3270082", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of DNA polymerase gamma"}
{"concept_id": "C3270084", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of DNA polymerase II"}
{"concept_id": "C3270085", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of DNA polymerase III"}
{"concept_id": "C3270086", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of DNA polymerase V activity"}
{"concept_id": "C3270087", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C3270088", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of iota DNA polymerase activity"}
{"concept_id": "C3270089", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of kappa DNA polymerase activity"}
{"concept_id": "C3270090", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of Klenow fragment"}
{"concept_id": "C3270091", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of lambda DNA polymerase activity"}
{"concept_id": "C3270092", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of mu DNA polymerase activity"}
{"concept_id": "C3270093", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of nu DNA polymerase activity"}
{"concept_id": "C3270094", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of sequenase"}
{"concept_id": "C3270095", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of sigma DNA polymerase activity"}
{"concept_id": "C3270096", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of Taq DNA polymerase"}
{"concept_id": "C3270097", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of Taq Pol I"}
{"concept_id": "C3270098", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of Tca DNA polymerase"}
{"concept_id": "C3270099", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of theta DNA polymerase activity"}
{"concept_id": "C3270100", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of zeta DNA polymerase activity"}
{"concept_id": "C3270101", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of alpha DNA polymerase activity"}
{"concept_id": "C3270102", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of beta DNA polymerase activity"}
{"concept_id": "C3270103", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of delta DNA polymerase activity"}
{"concept_id": "C3270104", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of deoxyribonucleic polymerase I"}
{"concept_id": "C3270105", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA polymerase alpha"}
{"concept_id": "C3270106", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA polymerase beta"}
{"concept_id": "C3270107", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA polymerase gamma"}
{"concept_id": "C3270108", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA polymerase I"}
{"concept_id": "C3270109", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA polymerase II"}
{"concept_id": "C3270110", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA polymerase III"}
{"concept_id": "C3270111", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA polymerase V activity"}
{"concept_id": "C3270112", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA-directed DNA polymerase activity"}
{"concept_id": "C3270113", "aliases": ["inhibition of duplicase", "negative regulation of duplicase", "downregulation of duplicase", "down-regulation of duplicase"], "types": ["T045"], "canonical_name": "down regulation of duplicase"}
{"concept_id": "C3270114", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C3270115", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of iota DNA polymerase activity"}
{"concept_id": "C3270116", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of kappa DNA polymerase activity"}
{"concept_id": "C3270117", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Klenow fragment"}
{"concept_id": "C3270118", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lambda DNA polymerase activity"}
{"concept_id": "C3270119", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mu DNA polymerase activity"}
{"concept_id": "C3270120", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nu DNA polymerase activity"}
{"concept_id": "C3270121", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sequenase"}
{"concept_id": "C3270122", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sigma DNA polymerase activity"}
{"concept_id": "C3270123", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Taq DNA polymerase"}
{"concept_id": "C3270124", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of Taq Pol I"}
{"concept_id": "C3270125", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Tca DNA polymerase"}
{"concept_id": "C3270126", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of theta DNA polymerase activity"}
{"concept_id": "C3270127", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of zeta DNA polymerase activity"}
{"concept_id": "C3270128", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of alpha DNA polymerase activity"}
{"concept_id": "C3270129", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of beta DNA polymerase activity"}
{"concept_id": "C3270130", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of delta DNA polymerase activity"}
{"concept_id": "C3270131", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of deoxyribonucleic polymerase I"}
{"concept_id": "C3270132", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of DNA polymerase alpha"}
{"concept_id": "C3270133", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of DNA polymerase beta"}
{"concept_id": "C3270134", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of DNA polymerase gamma"}
{"concept_id": "C3270135", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of DNA polymerase I"}
{"concept_id": "C3270136", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of DNA polymerase II"}
{"concept_id": "C3270137", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of DNA polymerase III"}
{"concept_id": "C3270138", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of DNA polymerase V activity"}
{"concept_id": "C3270139", "aliases": ["negative regulation of eta DNA polymerase activity"], "types": ["T044"], "canonical_name": "inhibition of eta DNA polymerase activity"}
{"concept_id": "C3270140", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C3270141", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of iota DNA polymerase activity"}
{"concept_id": "C3270142", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of kappa DNA polymerase activity"}
{"concept_id": "C3270143", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of Klenow fragment"}
{"concept_id": "C3270144", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of lambda DNA polymerase activity"}
{"concept_id": "C3270145", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of mu DNA polymerase activity"}
{"concept_id": "C3270146", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of nu DNA polymerase activity"}
{"concept_id": "C3270147", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of sequenase"}
{"concept_id": "C3270148", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of sigma DNA polymerase activity"}
{"concept_id": "C3270149", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of Taq DNA polymerase"}
{"concept_id": "C3270150", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of Taq Pol I"}
{"concept_id": "C3270151", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of Tca DNA polymerase"}
{"concept_id": "C3270152", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of theta DNA polymerase activity"}
{"concept_id": "C3270153", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of zeta DNA polymerase activity"}
{"concept_id": "C3270154", "aliases": ["up regulation of DNA duplicase activity", "upregulation of DNA replicase activity", "up regulation of deoxyribonucleic duplicase activity", "upregulation of DNA-directed DNA polymerase activity", "activation of DNA-dependent DNA polymerase activity", "upregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "upregulation of DNA nucleotidyltransferase (DNA-directed) activity", "up regulation of deoxyribonucleic acid duplicase activity", "up-regulation of DNA-dependent DNA polymerase activity", "positive regulation of deoxyribonucleic acid duplicase activity", "up-regulation of DNA nucleotidyltransferase (DNA-directed) activity", "positive regulation of DNA duplicase activity", "up-regulation of DNA-directed DNA polymerase activity", "activation of DNA nucleotidyltransferase (DNA-directed) activity", "positive regulation of DNA-dependent DNA polymerase activity", "positive regulation of deoxyribonucleic duplicase activity", "up-regulation of deoxyribonucleic acid duplicase activity", "up regulation of DNA nucleotidyltransferase (DNA-directed) activity", "up regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "upregulation of deoxyribonucleic duplicase activity", "up regulation of DNA-dependent DNA polymerase activity", "up-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "activation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "up-regulation of DNA replicase activity", "positive regulation of DNA nucleotidyltransferase (DNA-directed) activity", "activation of deoxyribonucleic acid duplicase activity", "activation of DNA replicase activity", "up-regulation of DNA duplicase activity", "up-regulation of deoxyribonucleic duplicase activity", "up regulation of DNA replicase activity", "activation of deoxyribonucleic duplicase activity", "activation of DNA duplicase activity", "upregulation of DNA duplicase activity", "upregulation of deoxyribonucleic acid duplicase activity", "up regulation of DNA-directed DNA polymerase activity", "positive regulation of DNA replicase activity", "positive regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity", "upregulation of DNA-dependent DNA polymerase activity"], "types": ["T045"], "canonical_name": "positive regulation of DNA-directed DNA polymerase activity", "definition": "Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity. [GOC:TermGenie]"}
{"concept_id": "C3270155", "aliases": [], "types": ["T045"], "canonical_name": "activation of alpha DNA polymerase activity"}
{"concept_id": "C3270156", "aliases": [], "types": ["T045"], "canonical_name": "activation of beta DNA polymerase activity"}
{"concept_id": "C3270157", "aliases": [], "types": ["T045"], "canonical_name": "activation of delta DNA polymerase activity"}
{"concept_id": "C3270158", "aliases": [], "types": ["T045"], "canonical_name": "activation of deoxyribonucleic polymerase I"}
{"concept_id": "C3270159", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA polymerase alpha"}
{"concept_id": "C3270160", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA polymerase beta"}
{"concept_id": "C3270161", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA polymerase gamma"}
{"concept_id": "C3270162", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA polymerase I"}
{"concept_id": "C3270163", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA polymerase II"}
{"concept_id": "C3270164", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA polymerase III"}
{"concept_id": "C3270165", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA polymerase V activity"}
{"concept_id": "C3270166", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA-directed DNA polymerase activity"}
{"concept_id": "C3270167", "aliases": ["up-regulation of duplicase", "positive regulation of duplicase", "upregulation of duplicase", "up regulation of duplicase"], "types": ["T045"], "canonical_name": "activation of duplicase"}
{"concept_id": "C3270168", "aliases": [], "types": ["T045"], "canonical_name": "activation of gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C3270169", "aliases": [], "types": ["T045"], "canonical_name": "activation of iota DNA polymerase activity"}
{"concept_id": "C3270170", "aliases": [], "types": ["T045"], "canonical_name": "activation of kappa DNA polymerase activity"}
{"concept_id": "C3270171", "aliases": [], "types": ["T045"], "canonical_name": "activation of Klenow fragment"}
{"concept_id": "C3270172", "aliases": [], "types": ["T045"], "canonical_name": "activation of lambda DNA polymerase activity"}
{"concept_id": "C3270173", "aliases": [], "types": ["T045"], "canonical_name": "activation of mu DNA polymerase activity"}
{"concept_id": "C3270174", "aliases": [], "types": ["T045"], "canonical_name": "activation of nu DNA polymerase activity"}
{"concept_id": "C3270175", "aliases": [], "types": ["T045"], "canonical_name": "activation of sequenase"}
{"concept_id": "C3270176", "aliases": [], "types": ["T045"], "canonical_name": "activation of sigma DNA polymerase activity"}
{"concept_id": "C3270177", "aliases": [], "types": ["T045"], "canonical_name": "activation of Taq DNA polymerase"}
{"concept_id": "C3270178", "aliases": [], "types": ["T045"], "canonical_name": "activation of Taq Pol I"}
{"concept_id": "C3270179", "aliases": [], "types": ["T045"], "canonical_name": "activation of Tca DNA polymerase"}
{"concept_id": "C3270180", "aliases": [], "types": ["T045"], "canonical_name": "activation of theta DNA polymerase activity"}
{"concept_id": "C3270181", "aliases": [], "types": ["T045"], "canonical_name": "activation of zeta DNA polymerase activity"}
{"concept_id": "C3270182", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of alpha DNA polymerase activity"}
{"concept_id": "C3270183", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of beta DNA polymerase activity"}
{"concept_id": "C3270184", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of delta DNA polymerase activity"}
{"concept_id": "C3270185", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of deoxyribonucleic polymerase I"}
{"concept_id": "C3270186", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA polymerase alpha"}
{"concept_id": "C3270187", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA polymerase beta"}
{"concept_id": "C3270188", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA polymerase gamma"}
{"concept_id": "C3270189", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA polymerase I"}
{"concept_id": "C3270190", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA polymerase II"}
{"concept_id": "C3270191", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA polymerase III"}
{"concept_id": "C3270192", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA polymerase V activity"}
{"concept_id": "C3270193", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C3270194", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of iota DNA polymerase activity"}
{"concept_id": "C3270195", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of kappa DNA polymerase activity"}
{"concept_id": "C3270196", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of Klenow fragment"}
{"concept_id": "C3270197", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of lambda DNA polymerase activity"}
{"concept_id": "C3270198", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mu DNA polymerase activity"}
{"concept_id": "C3270199", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of nu DNA polymerase activity"}
{"concept_id": "C3270200", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of sequenase"}
{"concept_id": "C3270201", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of sigma DNA polymerase activity"}
{"concept_id": "C3270202", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of Taq DNA polymerase"}
{"concept_id": "C3270203", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of Taq Pol I"}
{"concept_id": "C3270204", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of Tca DNA polymerase"}
{"concept_id": "C3270205", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of theta DNA polymerase activity"}
{"concept_id": "C3270206", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of zeta DNA polymerase activity"}
{"concept_id": "C3270207", "aliases": ["up-regulation of alpha DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of alpha DNA polymerase activity"}
{"concept_id": "C3270208", "aliases": ["up-regulation of beta DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of beta DNA polymerase activity"}
{"concept_id": "C3270209", "aliases": ["up-regulation of delta DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of delta DNA polymerase activity"}
{"concept_id": "C3270210", "aliases": ["up-regulation of deoxyribonucleic polymerase I"], "types": ["T044"], "canonical_name": "up regulation of deoxyribonucleic polymerase I"}
{"concept_id": "C3270211", "aliases": ["up-regulation of DNA polymerase alpha"], "types": ["T044"], "canonical_name": "up regulation of DNA polymerase alpha"}
{"concept_id": "C3270212", "aliases": ["up-regulation of DNA polymerase beta"], "types": ["T044"], "canonical_name": "up regulation of DNA polymerase beta"}
{"concept_id": "C3270213", "aliases": ["up-regulation of DNA polymerase gamma"], "types": ["T044"], "canonical_name": "up regulation of DNA polymerase gamma"}
{"concept_id": "C3270214", "aliases": ["upregulation of DNA polymerase I", "up-regulation of DNA polymerase I"], "types": ["T045"], "canonical_name": "up regulation of DNA polymerase I"}
{"concept_id": "C3270215", "aliases": ["up-regulation of DNA polymerase II"], "types": ["T044"], "canonical_name": "up regulation of DNA polymerase II"}
{"concept_id": "C3270216", "aliases": ["up-regulation of DNA polymerase III"], "types": ["T044"], "canonical_name": "up regulation of DNA polymerase III"}
{"concept_id": "C3270217", "aliases": ["up-regulation of DNA polymerase V activity"], "types": ["T044"], "canonical_name": "up regulation of DNA polymerase V activity"}
{"concept_id": "C3270218", "aliases": ["upregulation of epsilon DNA polymerase activity", "positive regulation of epsilon DNA polymerase activity", "up-regulation of epsilon DNA polymerase activity", "up regulation of epsilon DNA polymerase activity"], "types": ["T045"], "canonical_name": "activation of epsilon DNA polymerase activity"}
{"concept_id": "C3270219", "aliases": ["up-regulation of gamma DNA-directed DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C3270220", "aliases": ["up-regulation of iota DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of iota DNA polymerase activity"}
{"concept_id": "C3270221", "aliases": ["up-regulation of kappa DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of kappa DNA polymerase activity"}
{"concept_id": "C3270222", "aliases": ["up-regulation of Klenow fragment"], "types": ["T044"], "canonical_name": "up regulation of Klenow fragment"}
{"concept_id": "C3270223", "aliases": ["up-regulation of lambda DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of lambda DNA polymerase activity"}
{"concept_id": "C3270224", "aliases": ["up-regulation of mu DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of mu DNA polymerase activity"}
{"concept_id": "C3270225", "aliases": ["up-regulation of nu DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of nu DNA polymerase activity"}
{"concept_id": "C3270226", "aliases": ["up-regulation of sequenase"], "types": ["T044"], "canonical_name": "up regulation of sequenase"}
{"concept_id": "C3270227", "aliases": ["up-regulation of sigma DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of sigma DNA polymerase activity"}
{"concept_id": "C3270228", "aliases": ["up-regulation of Taq DNA polymerase"], "types": ["T044"], "canonical_name": "up regulation of Taq DNA polymerase"}
{"concept_id": "C3270229", "aliases": ["up-regulation of Taq Pol I"], "types": ["T044"], "canonical_name": "up regulation of Taq Pol I"}
{"concept_id": "C3270230", "aliases": ["up-regulation of Tca DNA polymerase"], "types": ["T044"], "canonical_name": "up regulation of Tca DNA polymerase"}
{"concept_id": "C3270231", "aliases": ["up-regulation of theta DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of theta DNA polymerase activity"}
{"concept_id": "C3270232", "aliases": ["up-regulation of zeta DNA polymerase activity"], "types": ["T044"], "canonical_name": "up regulation of zeta DNA polymerase activity"}
{"concept_id": "C3270233", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of alpha DNA polymerase activity"}
{"concept_id": "C3270234", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of beta DNA polymerase activity"}
{"concept_id": "C3270235", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of delta DNA polymerase activity"}
{"concept_id": "C3270236", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of deoxyribonucleic polymerase I"}
{"concept_id": "C3270237", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of DNA polymerase alpha"}
{"concept_id": "C3270238", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of DNA polymerase beta"}
{"concept_id": "C3270239", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of DNA polymerase gamma"}
{"concept_id": "C3270241", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of DNA polymerase II"}
{"concept_id": "C3270242", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of DNA polymerase III"}
{"concept_id": "C3270243", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of DNA polymerase V activity"}
{"concept_id": "C3270244", "aliases": ["upregulation of eta DNA polymerase activity", "positive regulation of eta DNA polymerase activity", "up regulation of eta DNA polymerase activity", "up-regulation of eta DNA polymerase activity"], "types": ["T045"], "canonical_name": "activation of eta DNA polymerase activity"}
{"concept_id": "C3270245", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of gamma DNA-directed DNA polymerase activity"}
{"concept_id": "C3270246", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of iota DNA polymerase activity"}
{"concept_id": "C3270247", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of kappa DNA polymerase activity"}
{"concept_id": "C3270248", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of Klenow fragment"}
{"concept_id": "C3270249", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of lambda DNA polymerase activity"}
{"concept_id": "C3270250", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of mu DNA polymerase activity"}
{"concept_id": "C3270251", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of nu DNA polymerase activity"}
{"concept_id": "C3270252", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of sequenase"}
{"concept_id": "C3270253", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of sigma DNA polymerase activity"}
{"concept_id": "C3270254", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of Taq DNA polymerase"}
{"concept_id": "C3270255", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of Taq Pol I"}
{"concept_id": "C3270256", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of Tca DNA polymerase"}
{"concept_id": "C3270257", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of theta DNA polymerase activity"}
{"concept_id": "C3270258", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of zeta DNA polymerase activity"}
{"concept_id": "C3270259", "aliases": ["regulation of neurokinin-1 receptor binding"], "types": ["T044"], "canonical_name": "regulation of substance P receptor binding", "definition": "Any process that modulates the frequency, rate or extent of substance P receptor binding. [GOC:TermGenie]"}
{"concept_id": "C3270260", "aliases": [], "types": ["T044"], "canonical_name": "regulation of substance P receptor ligand"}
{"concept_id": "C3270262", "aliases": ["down-regulation of substance P receptor ligand"], "types": ["T044"], "canonical_name": "down regulation of substance P receptor ligand"}
{"concept_id": "C3270263", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of substance P receptor ligand"}
{"concept_id": "C3270265", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of substance P receptor ligand"}
{"concept_id": "C3270266", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of substance P receptor ligand"}
{"concept_id": "C3270269", "aliases": [], "types": ["T044"], "canonical_name": "activation of substance P receptor ligand"}
{"concept_id": "C3270270", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of substance P receptor ligand"}
{"concept_id": "C3270271", "aliases": ["up-regulation of substance P receptor ligand"], "types": ["T044"], "canonical_name": "up regulation of substance P receptor ligand"}
{"concept_id": "C3270272", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of substance P receptor ligand"}
{"concept_id": "C3270273", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reverse transcription", "definition": "Any process that modulates the frequency, rate or extent of reverse transcription. [GOC:TermGenie]"}
{"concept_id": "C3270274", "aliases": ["downregulation of reverse transcription", "down regulation of reverse transcription", "down-regulation of reverse transcription"], "types": ["T043"], "canonical_name": "negative regulation of reverse transcription", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of reverse transcription. [GOC:TermGenie]"}
{"concept_id": "C3270275", "aliases": ["upregulation of reverse transcription", "up regulation of reverse transcription", "up-regulation of reverse transcription"], "types": ["T045"], "canonical_name": "positive regulation of reverse transcription", "definition": "Any process that activates or increases the frequency, rate or extent of reverse transcription. [GOC:TermGenie]"}
{"concept_id": "C3270276", "aliases": [], "types": ["T045"], "canonical_name": "activation of reverse transcription"}
{"concept_id": "C3270277", "aliases": [], "types": ["T040"], "canonical_name": "regulation of seed dormancy process", "definition": "Any process that modulates the frequency, rate or extent of seed dormancy process. [GOC:obol, GOC:pr, ISBN:9781405139830]"}
{"concept_id": "C3270279", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene silencing by microRNA"}
{"concept_id": "C3270280", "aliases": ["myosin filament organisation involved in cytokinetic actomyosin contractile ring assembly", "myosin filament organization of contractile ring assembly", "myosin filament organization of cytokinesis, actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "myosin filament organization involved in cytokinetic actomyosin contractile ring assembly", "definition": "A myosin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis. [GOC:mah]"}
{"concept_id": "C3270281", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament assembly or disassembly of constriction ring assembly"}
{"concept_id": "C3270282", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament assembly or disassembly of contractile ring assembly"}
{"concept_id": "C3270283", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring assembly"}
{"concept_id": "C3270284", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring formation"}
{"concept_id": "C3270285", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament assembly or disassembly of cytokinesis, actomyosin ring biosynthesis"}
{"concept_id": "C3270286", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament assembly or disassembly of cytokinesis, actomyosin ring formation"}
{"concept_id": "C3270287", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament assembly or disassembly of cytokinesis, contractile ring assembly"}
{"concept_id": "C3270288", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament organization of constriction ring assembly"}
{"concept_id": "C3270289", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament organization of cytokinesis, actomyosin contractile ring formation"}
{"concept_id": "C3270290", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament organization of cytokinesis, actomyosin ring biosynthesis"}
{"concept_id": "C3270291", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament organization of cytokinesis, actomyosin ring formation"}
{"concept_id": "C3270292", "aliases": [], "types": ["T043"], "canonical_name": "myosin filament organization of cytokinesis, contractile ring assembly"}
{"concept_id": "C3270293", "aliases": [], "types": ["T043"], "canonical_name": "myosin polymerization or depolymerization of constriction ring assembly"}
{"concept_id": "C3270294", "aliases": [], "types": ["T043"], "canonical_name": "myosin polymerization or depolymerization of contractile ring assembly"}
{"concept_id": "C3270295", "aliases": [], "types": ["T043"], "canonical_name": "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring assembly"}
{"concept_id": "C3270296", "aliases": [], "types": ["T043"], "canonical_name": "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring formation"}
{"concept_id": "C3270297", "aliases": [], "types": ["T043"], "canonical_name": "myosin polymerization or depolymerization of cytokinesis, actomyosin ring biosynthesis"}
{"concept_id": "C3270298", "aliases": [], "types": ["T043"], "canonical_name": "myosin polymerization or depolymerization of cytokinesis, actomyosin ring formation"}
{"concept_id": "C3270299", "aliases": [], "types": ["T043"], "canonical_name": "myosin polymerization or depolymerization of cytokinesis, contractile ring assembly"}
{"concept_id": "C3270300", "aliases": ["regulation of maintenance of sister chromatin cohesion at centromere at meiosis I", "regulation of maintenance of centromeric meiotic sister chromatin cohesion", "regulation of maintenance of meiotic sister chromatin cohesion at centromere"], "types": ["T043"], "canonical_name": "regulation of maintenance of meiotic sister chromatid cohesion, centromeric", "definition": "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region. [GOC:mah]"}
{"concept_id": "C3270301", "aliases": ["negative regulation of maintenance of centromeric meiotic sister chromatin cohesion", "negative regulation of maintenance of sister chromatin cohesion at centromere at meiosis I", "negative regulation of maintenance of meiotic sister chromatin cohesion at centromere"], "types": ["T043"], "canonical_name": "negative regulation of maintenance of meiotic sister chromatid cohesion, centromeric", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region. [GOC:mah]"}
{"concept_id": "C3270302", "aliases": ["positive regulation of maintenance of centromeric meiotic sister chromatin cohesion", "positive regulation of maintenance of sister chromatin cohesion at centromere at meiosis I", "positive regulation of maintenance of meiotic sister chromatin cohesion at centromere"], "types": ["T043"], "canonical_name": "positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric", "definition": "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region. [GOC:mah]"}
{"concept_id": "C3270303", "aliases": ["regulation of maintenance of sister chromatin cohesion along arms at meiosis I", "regulation of maintenance of meiotic sister chromatin cohesion along arms"], "types": ["T043"], "canonical_name": "regulation of maintenance of meiotic sister chromatid cohesion, arms", "definition": "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms. [GOC:mah]"}
{"concept_id": "C3270304", "aliases": ["negative regulation of maintenance of meiotic sister chromatin cohesion along arms", "negative regulation of maintenance of sister chromatin cohesion along arms at meiosis I"], "types": ["T043"], "canonical_name": "negative regulation of maintenance of meiotic sister chromatid cohesion, arms", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms. [GOC:mah]"}
{"concept_id": "C3270305", "aliases": ["positive regulation of maintenance of meiotic sister chromatin cohesion along arms", "positive regulation of maintenance of sister chromatin cohesion along arms at meiosis I"], "types": ["T043"], "canonical_name": "positive regulation of maintenance of meiotic sister chromatid cohesion, arms", "definition": "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms. [GOC:mah]"}
{"concept_id": "C3270306", "aliases": ["regulation of maintenance of sister chromatin cohesion along arms at mitosis", "regulation of maintenance of mitotic sister chromatin cohesion along arms"], "types": ["T043"], "canonical_name": "regulation of maintenance of mitotic sister chromatid cohesion, arms", "definition": "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms. [GOC:mah]"}
{"concept_id": "C3270307", "aliases": ["negative regulation of maintenance of mitotic sister chromatin cohesion along arms", "negative regulation of maintenance of sister chromatin cohesion along arms at mitosis"], "types": ["T043"], "canonical_name": "negative regulation of maintenance of mitotic sister chromatid cohesion, arms", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms. [GOC:mah]"}
{"concept_id": "C3270308", "aliases": ["positive regulation of maintenance of sister chromatin cohesion along arms at mitosis", "positive regulation of maintenance of mitotic sister chromatin cohesion along arms"], "types": ["T043"], "canonical_name": "positive regulation of maintenance of mitotic sister chromatid cohesion, arms", "definition": "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms. [GOC:mah]"}
{"concept_id": "C3270309", "aliases": ["regulation of maintenance of centromeric mitotic sister chromatin cohesion", "regulation of maintenance of sister chromatin cohesion at centromere at mitosis", "regulation of maintenance of mitotic sister chromatin cohesion at centromere"], "types": ["T043"], "canonical_name": "regulation of maintenance of mitotic sister chromatid cohesion, centromeric", "definition": "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region. [GOC:mah]"}
{"concept_id": "C3270310", "aliases": ["negative regulation of maintenance of mitotic sister chromatin cohesion at centromere", "negative regulation of maintenance of centromeric mitotic sister chromatin cohesion", "negative regulation of maintenance of sister chromatin cohesion at centromere at mitosis"], "types": ["T043"], "canonical_name": "negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region. [GOC:mah]"}
{"concept_id": "C3270311", "aliases": ["positive regulation of maintenance of sister chromatin cohesion at centromere at mitosis", "positive regulation of maintenance of mitotic sister chromatin cohesion at centromere", "positive regulation of maintenance of centromeric mitotic sister chromatin cohesion"], "types": ["T043"], "canonical_name": "positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric", "definition": "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region. [GOC:mah]"}
{"concept_id": "C3270312", "aliases": ["up-regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation", "activation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation", "positive regulation of transcription from Pol II promoter of nonstriated muscle cell differentiation", "up regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation", "positive regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation", "stimulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation", "up regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation", "activation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation", "positive regulation of transcription from Pol II promoter of smooth muscle cell differentiation", "positive regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation", "upregulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation", "stimulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation", "up-regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation", "definition": "Any positive regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation. [GOC:BHF]"}
{"concept_id": "C3270313", "aliases": [], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation"}
{"concept_id": "C3270314", "aliases": [], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation"}
{"concept_id": "C3270315", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation"}
{"concept_id": "C3270316", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter of smooth muscle cell differentiation"}
{"concept_id": "C3270317", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of global transcription from Pol II promoter of nonstriated muscle cell differentiation"}
{"concept_id": "C3270318", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of global transcription from Pol II promoter of smooth muscle cell differentiation"}
{"concept_id": "C3270319", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter, global of nonstriated muscle cell differentiation"}
{"concept_id": "C3270320", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter, global of smooth muscle cell differentiation"}
{"concept_id": "C3270321", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation"}
{"concept_id": "C3270322", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation"}
{"concept_id": "C3270323", "aliases": ["up-regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation"], "types": ["T045"], "canonical_name": "up regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation"}
{"concept_id": "C3270324", "aliases": ["up-regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation"], "types": ["T045"], "canonical_name": "up regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation"}
{"concept_id": "C3270325", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation"}
{"concept_id": "C3270326", "aliases": ["regulation of heart vascular smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "regulation of cardiac vascular smooth muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation. [GOC:BHF]"}
{"concept_id": "C3270327", "aliases": ["negative regulation of heart vascular smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of cardiac vascular smooth muscle cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation. [GOC:BHF]"}
{"concept_id": "C3270328", "aliases": ["positive regulation of heart vascular smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of cardiac vascular smooth muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation. [GOC:BHF]"}
{"concept_id": "C3270329", "aliases": ["regulation of heart muscle cell differentiation", "regulation of cardiomyocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of cardiac muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]"}
{"concept_id": "C3270330", "aliases": [], "types": ["T045"], "canonical_name": "spliceosome disassembly"}
{"concept_id": "C3270332", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome b6f complex activity"}
{"concept_id": "C3270333", "aliases": [], "types": ["T044"], "canonical_name": "catechol-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. [GOC:sm, ISBN:0198547684]"}
{"concept_id": "C3270334", "aliases": [], "types": ["T043"], "canonical_name": "sugar utilization"}
{"concept_id": "C3270335", "aliases": [], "types": ["T044"], "canonical_name": "jasmonate signaling"}
{"concept_id": "C3270337", "aliases": [], "types": ["T039"], "canonical_name": "seed dormancy process", "definition": "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors. [GOC:lr, GOC:PO_curators, ISBN:9781405139830, PO_REF:00009]"}
{"concept_id": "C3270338", "aliases": ["positive regulation of protein maturation by peptide bond cleavage"], "types": ["T045"], "canonical_name": "positive regulation of protein processing", "definition": "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C3270339", "aliases": ["negative regulation of protein maturation by peptide bond cleavage"], "types": ["T045"], "canonical_name": "negative regulation of protein processing", "definition": "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C3270343", "aliases": ["negative regulation of cardiomyocyte differentiation", "negative regulation of heart muscle cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of cardiac muscle cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]"}
{"concept_id": "C3270344", "aliases": ["positive regulation of heart muscle cell differentiation", "positive regulation of cardiomyocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of cardiac muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]"}
{"concept_id": "C3270345", "aliases": ["regulation of mRNA export from cell nucleus during heat stress", "regulation of mRNA export from nucleus during heat stress"], "types": ["T043"], "canonical_name": "regulation of mRNA export from nucleus in response to heat stress", "definition": "Any process that modulates the frequency, rate or extent of mRNA export from nucleus in response to heat stress. [PMID:15210706]"}
{"concept_id": "C3270346", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal cell proliferation involved in ureter development", "definition": "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development. [GOC:obol]"}
{"concept_id": "C3270347", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ureter mesenchymal cell proliferation"}
{"concept_id": "C3270348", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ureteral mesenchymal cell proliferation"}
{"concept_id": "C3270349", "aliases": ["regulation of transcription termination from Pol I promoter", "regulation of transcription termination from RNA polymerase I promoter", "regulation of RNA polymerase I transcription termination"], "types": ["T045"], "canonical_name": "regulation of termination of RNA polymerase I transcription", "definition": "Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription. [GOC:obol]"}
{"concept_id": "C3270350", "aliases": ["negative regulation of transcription termination from RNA polymerase I promoter", "negative regulation of RNA polymerase I transcription termination", "negative regulation of transcription termination from Pol I promoter"], "types": ["T044"], "canonical_name": "negative regulation of termination of RNA polymerase I transcription", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase I transcription. [GOC:obol]"}
{"concept_id": "C3270351", "aliases": ["positive regulation of transcription termination from Pol I promoter", "positive regulation of transcription termination from RNA polymerase I promoter", "positive regulation of RNA polymerase I transcription termination"], "types": ["T045"], "canonical_name": "positive regulation of termination of RNA polymerase I transcription", "definition": "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase I transcription. [GOC:obol]"}
{"concept_id": "C3270352", "aliases": ["regulation of GDNF receptor signaling pathway of ureteric bud formation", "regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation", "regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation", "regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation", "regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation"], "types": ["T044"], "canonical_name": "regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation", "definition": "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation. [GOC:obol]"}
{"concept_id": "C3270353", "aliases": ["negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation", "negative regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation", "negative regulation of GDNF receptor signaling pathway of ureteric bud formation", "negative regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation", "negative regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation"], "types": ["T044"], "canonical_name": "negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation. [GOC:obol]"}
{"concept_id": "C3270354", "aliases": ["positive regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation", "positive regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation", "positive regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation", "positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation", "positive regulation of GDNF receptor signaling pathway of ureteric bud formation"], "types": ["T044"], "canonical_name": "positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation", "definition": "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation. [GOC:obol]"}
{"concept_id": "C3270355", "aliases": [], "types": ["T043"], "canonical_name": "regulation of stem cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of stem cell differentiation. [GOC:obol]"}
{"concept_id": "C3270356", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of stem cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. [GOC:obol]"}
{"concept_id": "C3270357", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of stem cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of stem cell differentiation. [GOC:obol]"}
{"concept_id": "C3270358", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mesenchymal stem cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation. [GOC:obol]"}
{"concept_id": "C3270359", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mesenchymal stem cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation. [GOC:obol]"}
{"concept_id": "C3270360", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal stem cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell differentiation. [GOC:obol]"}
{"concept_id": "C3270361", "aliases": [], "types": ["T038"], "canonical_name": "regulation of anterior head development", "definition": "Any process that modulates the frequency, rate or extent of anterior head development. [GOC:obol]"}
{"concept_id": "C3270362", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of anterior head development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anterior head development. [GOC:obol]"}
{"concept_id": "C3270363", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of anterior head development", "definition": "Any process that activates or increases the frequency, rate or extent of anterior head development. [GOC:obol]"}
{"concept_id": "C3270369", "aliases": ["regulation of defecation cycle", "regulation of defecation motor program", "regulation of DMP"], "types": ["T038"], "canonical_name": "regulation of defecation rhythm", "definition": "Any process that modulates the frequency, rate or extent of defecation rhythm. [GOC:kmv]"}
{"concept_id": "C3270370", "aliases": [], "types": ["T038"], "canonical_name": "regulation of defecation behavior"}
{"concept_id": "C3270371", "aliases": ["negative regulation of defecation cycle", "negative regulation of defecation motor program", "negative regulation of DMP"], "types": ["T038"], "canonical_name": "negative regulation of defecation rhythm", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of defecation rhythm. [GOC:kmv]"}
{"concept_id": "C3270372", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of defecation behavior"}
{"concept_id": "C3270373", "aliases": ["positive regulation of defecation cycle", "positive regulation of defecation motor program", "positive regulation of DMP"], "types": ["T038"], "canonical_name": "positive regulation of defecation rhythm", "definition": "Any process that activates or increases the frequency, rate or extent of defecation rhythm. [GOC:kmv]"}
{"concept_id": "C3270374", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of defecation behavior"}
{"concept_id": "C3270375", "aliases": ["positive regulation of chromatin silencing at ribosomal DNA", "positive regulation of heterochromatic silencing at rDNA", "positive regulation of rDNA chromatin silencing"], "types": ["T045"], "canonical_name": "positive regulation of chromatin silencing at rDNA"}
{"concept_id": "C3270376", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape. [GOC:mah]"}
{"concept_id": "C3270377", "aliases": ["histone H3-T3 phosphorylation of CPC localization to kinetochore", "histone H3-T3 phosphorylation of chromosome passenger complex localisation to kinetochore", "histone H3-T3 phosphorylation of CPC complex localization to kinetochore", "histone H3-T3 phosphorylation of chromosomal passenger complex localization to kinetochore", "histone H3-T3 phosphorylation of chromosome passenger complex localization to kinetochore"], "types": ["T044"], "canonical_name": "histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore", "definition": "Any histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore. [GOC:obol]"}
{"concept_id": "C3270379", "aliases": ["regulation of glucosylceramide degradation", "regulation of glucosylceramide breakdown", "regulation of glucosylceramide catabolism"], "types": ["T044"], "canonical_name": "regulation of glucosylceramide catabolic process", "definition": "Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process. [GOC:BHF]"}
{"concept_id": "C3270380", "aliases": ["positive regulation of glucosylceramide degradation", "positive regulation of glucosylceramide catabolism", "positive regulation of glucosylceramide breakdown"], "types": ["T044"], "canonical_name": "positive regulation of glucosylceramide catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process. [GOC:BHF]"}
{"concept_id": "C3270381", "aliases": ["regulation of sphingomyelin degradation", "regulation of sphingomyelin breakdown", "regulation of sphingomyelin catabolism"], "types": ["T044"], "canonical_name": "regulation of sphingomyelin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process. [GOC:BHF]"}
{"concept_id": "C3270382", "aliases": ["positive regulation of sphingomyelin breakdown", "positive regulation of sphingomyelin degradation", "positive regulation of sphingomyelin catabolism"], "types": ["T044"], "canonical_name": "positive regulation of sphingomyelin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process. [GOC:BHF]"}
{"concept_id": "C3270383", "aliases": [], "types": ["T044"], "canonical_name": "regulation of peptidyl-lysine acetylation", "definition": "Any process that modulates the frequency, rate or extent of peptidyl-lysine acetylation. [GOC:obol]"}
{"concept_id": "C3270384", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of peptidyl-lysine acetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation. [GOC:obol]"}
{"concept_id": "C3270385", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of peptidyl-lysine acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation. [GOC:obol]"}
{"concept_id": "C3270386", "aliases": [], "types": ["T044"], "canonical_name": "regulation of N-terminal peptidyl-lysine acetylation", "definition": "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-lysine acetylation. [GOC:obol]"}
{"concept_id": "C3270387", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of N-terminal peptidyl-lysine acetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-lysine acetylation. [GOC:obol]"}
{"concept_id": "C3270388", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of N-terminal peptidyl-lysine acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation. [GOC:obol]"}
{"concept_id": "C3270389", "aliases": ["regulation of phenylpropanoid metabolism"], "types": ["T040"], "canonical_name": "regulation of phenylpropanoid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of phenylpropanoid metabolic process. [GOC:obol]"}
{"concept_id": "C3270390", "aliases": ["positive regulation of transcription from Pol II promoter involved in levarterenol biosynthetic process", "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthesis", "positive regulation of transcription from Pol II promoter involved in levarterenol biosynthesis", "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthesis", "positive regulation of transcription from Pol II promoter involved in norepinephrine formation", "positive regulation of transcription from Pol II promoter involved in norepinephrine anabolism", "positive regulation of transcription from Pol II promoter involved in norepinephrine synthesis", "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthetic process", "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthetic process"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process", "definition": "Any positive regulation of transcription from RNA polymerase II promoter that is involved in norepinephrine biosynthetic process. [GOC:BHF]"}
{"concept_id": "C3270391", "aliases": ["positive regulation of semaphorin-plexin signalling pathway involved in outflow tract morphogenesis"], "types": ["T042"], "canonical_name": "positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis. [GOC:BHF]"}
{"concept_id": "C3270392", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic translation", "definition": "Any process that modulates the frequency, rate or extent of cytoplasmic translation. [GOC:obol]"}
{"concept_id": "C3270393", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of cytoplasmic translation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation. [GOC:obol]"}
{"concept_id": "C3270394", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of cytoplasmic translation", "definition": "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation. [GOC:obol]"}
{"concept_id": "C3270395", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of nephron tubule epithelial cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of nephron tubule epithelial cell differentiation. [GOC:obol]"}
{"concept_id": "C3270396", "aliases": [], "types": ["T038"], "canonical_name": "regulation of establishment or maintenance of cell polarity regulating cell shape", "definition": "Any process that modulates the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape. [GOC:mah]"}
{"concept_id": "C3270397", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of establishment or maintenance of cell polarity regulating cell shape", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape. [GOC:mah]"}
{"concept_id": "C3270398", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of establishment or maintenance of cell polarity regulating cell shape", "definition": "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape. [GOC:mah]"}
{"concept_id": "C3270399", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cellular senescence", "definition": "Any process that modulates the frequency, rate or extent of cellular senescence. [GOC:BHF]"}
{"concept_id": "C3270400", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular senescence", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence. [GOC:BHF]"}
{"concept_id": "C3270401", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cellular senescence", "definition": "Any process that activates or increases the frequency, rate or extent of cellular senescence. [GOC:BHF]"}
{"concept_id": "C3270403", "aliases": ["histone H4 acetylation of cellular response to DNA damage stimulus", "histone H4 acetylation of response to DNA damage stimulus", "histone H4 acetylation of cellular DNA damage response", "histone H4 acetylation of response to genotoxic stress", "histone H4 acetylation of DNA damage response"], "types": ["T044"], "canonical_name": "histone H4 acetylation involved in response to DNA damage stimulus", "definition": "Any histone H4 acetylation that is involved in a response to DNA damage stimulus. [GOC:mah]"}
{"concept_id": "C3270404", "aliases": ["positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to lowered oxygen tension", "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxic stress"], "types": ["T043"], "canonical_name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia", "definition": "Any positive regulation of proteasomal ubiquitin-dependent protein catabolic process that is involved in a cellular response to hypoxia. [GOC:mah]"}
{"concept_id": "C3270406", "aliases": [], "types": ["T045"], "canonical_name": "regulation of double-strand break repair", "definition": "Any process that modulates the frequency, rate or extent of double-strand break repair. [GOC:BHF]"}
{"concept_id": "C3270407", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of double-strand break repair", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair. [GOC:BHF]"}
{"concept_id": "C3270408", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of double-strand break repair", "definition": "Any process that activates or increases the frequency, rate or extent of double-strand break repair. [GOC:BHF]"}
{"concept_id": "C3270409", "aliases": [], "types": ["T043"], "canonical_name": "regulation of establishment of cell polarity regulating cell shape", "definition": "Any process that modulates the frequency, rate or extent of establishment of cell polarity regulating cell shape. [GOC:Mah]"}
{"concept_id": "C3270410", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of establishment of cell polarity regulating cell shape", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of cell polarity regulating cell shape. [GOC:Mah]"}
{"concept_id": "C3270411", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of establishment of cell polarity regulating cell shape", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of cell polarity regulating cell shape. [GOC:Mah]"}
{"concept_id": "C3270412", "aliases": ["regulation of autophagosome biosynthesis", "regulation of autophagic vacuole formation", "regulation of autophagic vacuole assembly", "regulation of autophagosome formation"], "types": ["T043"], "canonical_name": "regulation of autophagosome assembly", "definition": "Any process that modulates the frequency, rate or extent of autophagosome assembly. [GOC:autophagy, GOC:BHF]"}
{"concept_id": "C3270413", "aliases": [], "types": ["T043"], "canonical_name": "regulation of PAS formation"}
{"concept_id": "C3270414", "aliases": ["positive regulation of autophagic vacuole assembly", "positive regulation of autophagic vacuole formation", "positive regulation of autophagosome formation", "positive regulation of autophagosome biosynthesis"], "types": ["T043"], "canonical_name": "positive regulation of autophagosome assembly", "definition": "Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly. [GOC:autophagy, GOC:BHF]"}
{"concept_id": "C3270415", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of PAS formation"}
{"concept_id": "C3270416", "aliases": [], "types": ["T043"], "canonical_name": "regulation of venous endothelial cell fate commitment", "definition": "Any process that modulates the frequency, rate or extent of venous endothelial cell fate commitment. [PMID:11585794]"}
{"concept_id": "C3270417", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of venous endothelial cell fate commitment", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of venous endothelial cell fate commitment. [PMID:11585794]"}
{"concept_id": "C3270418", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of venous endothelial cell fate commitment", "definition": "Any process that activates or increases the frequency, rate or extent of venous endothelial cell fate commitment. [PMID:11585794]"}
{"concept_id": "C3270419", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mesenchymal cell proliferation involved in lung development", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. [PMID:21513708]"}
{"concept_id": "C3270420", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of mesenchymal cell proliferation involved in lung development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. [PMID:21513708]"}
{"concept_id": "C3270421", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal cell proliferation involved in lung development", "definition": "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. [PMID:21513708]"}
{"concept_id": "C3270422", "aliases": ["cell proliferation of cardiac valve development", "cell proliferation of heart valve development"], "types": ["T043"], "canonical_name": "cell proliferation involved in heart valve development", "definition": "Any cell proliferation that is involved in heart valve development. [GOC:BHF]"}
{"concept_id": "C3270423", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial cell proliferation involved in lung morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. [PMID:21513708]"}
{"concept_id": "C3270424", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of epithelial cell proliferation involved in lung morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. [PMID:21513708]"}
{"concept_id": "C3270425", "aliases": ["Notch receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment", "Notch receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment", "N signaling pathway involved in negative regulation of venous endothelial cell fate commitment", "Notch-receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment", "Notch signalling pathway involved in negative regulation of venous endothelial cell fate commitment", "Notch-receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment"], "types": ["T044"], "canonical_name": "Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment", "definition": "Any Notch signaling pathway that is involved in negative regulation of venous endothelial cell fate commitment. [PMID:11585794]"}
{"concept_id": "C3270426", "aliases": [], "types": ["T043"], "canonical_name": "regulation of amniotic stem cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of amniotic stem cell differentiation. [GOC:obol]"}
{"concept_id": "C3270427", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of amniotic stem cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation. [GOC:obol]"}
{"concept_id": "C3270428", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of amniotic stem cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of amniotic stem cell differentiation. [GOC:obol]"}
{"concept_id": "C3270429", "aliases": ["regulation of endocardial cushion to mesenchymal transition involved in valve formation"], "types": ["T043"], "canonical_name": "regulation of endocardial cushion to mesenchymal transition involved in heart valve formation", "definition": "Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation. [GOC:BHF]"}
{"concept_id": "C3270430", "aliases": ["negative regulation of endocardial cushion to mesenchymal transition involved in valve formation"], "types": ["T043"], "canonical_name": "negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation. [GOC:BHF]"}
{"concept_id": "C3270431", "aliases": ["positive regulation of endocardial cushion to mesenchymal transition involved in valve formation"], "types": ["T043"], "canonical_name": "positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation", "definition": "Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation. [GOC:BHF]"}
{"concept_id": "C3270432", "aliases": ["endosome-based signaling", "signaling from endosome"], "types": ["T043"], "canonical_name": "endosomal signal transduction", "definition": "The process in which a signal is passed on to downstream components located at the endosome. Endosomes can provide important intracellular signaling platforms and provide spatial and temporal control over signal transduction. [GOC:bf, GOC:signaling, PMID:15084302, PMID:17662591]"}
{"concept_id": "C3270433", "aliases": ["signalling cascade in endosome"], "types": ["T043"], "canonical_name": "signaling cascade in endosome"}
{"concept_id": "C3270434", "aliases": ["signalling pathway in endosome"], "types": ["T043"], "canonical_name": "signaling pathway in endosome"}
{"concept_id": "C3270435", "aliases": [], "types": ["T045"], "canonical_name": "regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "definition": "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled. [GOC:obol]"}
{"concept_id": "C3270436", "aliases": ["regulation of transcription termination from Pol II promoter, poly(A) coupled"], "types": ["T045"], "canonical_name": "regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled"}
{"concept_id": "C3270437", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled. [GOC:obol]"}
{"concept_id": "C3270438", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription termination from Pol II promoter, poly(A) coupled"}
{"concept_id": "C3270439", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled"}
{"concept_id": "C3270440", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "definition": "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled. [GOC:obol]"}
{"concept_id": "C3270441", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription termination from Pol II promoter, poly(A) coupled"}
{"concept_id": "C3270442", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled"}
{"concept_id": "C3270443", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle clustering", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle clustering. [PMID:21513708]"}
{"concept_id": "C3270444", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle clustering", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle clustering. [PMID:21513708]"}
{"concept_id": "C3270445", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle clustering", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering. [PMID:21513708]"}
{"concept_id": "C3270446", "aliases": ["regulation of tight junction formation"], "types": ["T043"], "canonical_name": "regulation of bicellular tight junction assembly", "definition": "Any process that modulates the frequency, rate or extent of tight junction assembly. [GOC:BHF]"}
{"concept_id": "C3270447", "aliases": ["regulation of barbed-end F-actin capping activity", "regulation of plus-end F-actin capping activity", "regulation of barbed-end actin capping activity", "regulation of plus-end actin filament capping activity"], "types": ["T043"], "canonical_name": "regulation of barbed-end actin filament capping", "definition": "Any process that modulates the frequency, rate or extent of barbed-end actin filament capping. [GOC:BHF]"}
{"concept_id": "C3270448", "aliases": ["negative regulation of barbed-end actin capping activity", "negative regulation of barbed-end F-actin capping activity", "negative regulation of plus-end actin filament capping activity", "negative regulation of plus-end F-actin capping activity"], "types": ["T043"], "canonical_name": "negative regulation of barbed-end actin filament capping", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of barbed-end actin filament capping. [GOC:BHF]"}
{"concept_id": "C3270449", "aliases": ["positive regulation of barbed-end F-actin capping activity", "positive regulation of plus-end F-actin capping activity", "positive regulation of plus-end actin filament capping activity", "positive regulation of barbed-end actin capping activity"], "types": ["T043"], "canonical_name": "positive regulation of barbed-end actin filament capping", "definition": "Any process that activates or increases the frequency, rate or extent of barbed-end actin filament capping. [GOC:BHF]"}
{"concept_id": "C3270450", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA stability involved in response to oxidative stress", "definition": "A process of regulation of mRNA stability that is involved in a response to oxidative stress. [GOC:obol]"}
{"concept_id": "C3270451", "aliases": ["negative regulation of sister chromatid separation during mitosis", "negative regulation of mitotic sister chromatid resolution"], "types": ["T043"], "canonical_name": "negative regulation of mitotic sister chromatid separation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation. [GOC:obol]"}
{"concept_id": "C3270452", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of chromosome separation during mitosis"}
{"concept_id": "C3270453", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic chromosome separation"}
{"concept_id": "C3270454", "aliases": ["regulation of histone H3-T3 phosphorylation involved in CPC complex localization to kinetochore", "regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localisation to kinetochore", "regulation of histone H3-T3 phosphorylation involved in chromosomal passenger complex localization to kinetochore", "regulation of histone H3-T3 phosphorylation involved in CPC localization to kinetochore"], "types": ["T044"], "canonical_name": "regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore", "definition": "Any regulation of histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore. [GOC:obol]"}
{"concept_id": "C3270455", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myoblast proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. [GOC:obol]"}
{"concept_id": "C3270456", "aliases": ["regulation of NER", "regulation of pyrimidine-dimer repair, DNA damage excision"], "types": ["T045"], "canonical_name": "regulation of nucleotide-excision repair", "definition": "Any process that modulates the frequency, rate or extent of nucleotide-excision repair. [GOC:jp, PMID:18836076]"}
{"concept_id": "C3270457", "aliases": ["regulation of intrastrand cross-link repair"], "types": ["T045"], "canonical_name": "regulation of interstrand crosslink repair"}
{"concept_id": "C3270458", "aliases": ["negative regulation of transcription from Pol II promoter involved in nonstriated muscle cell differentiation", "down-regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation", "down regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation", "negative regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation", "inhibition of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation", "downregulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation", "down regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation", "negative regulation of transcription from Pol II promoter involved in smooth muscle cell differentiation", "down-regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation", "downregulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation", "inhibition of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation"], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation", "definition": "Any negative regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation. [GOC:BHF]"}
{"concept_id": "C3270459", "aliases": ["down-regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation", "downregulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation"], "types": ["T045"], "canonical_name": "down regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation"}
{"concept_id": "C3270460", "aliases": ["down-regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation"], "types": ["T045"], "canonical_name": "down regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation"}
{"concept_id": "C3270461", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation"}
{"concept_id": "C3270462", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation"}
{"concept_id": "C3270463", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation"}
{"concept_id": "C3270464", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation"}
{"concept_id": "C3270465", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation"}
{"concept_id": "C3270466", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of global transcription from Pol II promoter involved in nonstriated muscle cell differentiation"}
{"concept_id": "C3270467", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of global transcription from Pol II promoter involved in smooth muscle cell differentiation"}
{"concept_id": "C3270468", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter, global involved in nonstriated muscle cell differentiation"}
{"concept_id": "C3270469", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter, global involved in smooth muscle cell differentiation"}
{"concept_id": "C3270470", "aliases": ["regulation of grooming behaviour"], "types": ["T055"], "canonical_name": "regulation of grooming behavior", "definition": "Any process that modulates the frequency, rate or extent of grooming behavior. [GOC:BHF]"}
{"concept_id": "C3270471", "aliases": ["regulation of behavioural fear response"], "types": ["T040"], "canonical_name": "regulation of behavioral fear response", "definition": "Any process that modulates the frequency, rate or extent of behavioral fear response. [GOC:BHF]"}
{"concept_id": "C3270472", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of androgen receptor activity"}
{"concept_id": "C3270473", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of androgen receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of androgen receptor activity. [GOC:obol]"}
{"concept_id": "C3270474", "aliases": ["regulation of cardiac morphogenesis"], "types": ["T042"], "canonical_name": "regulation of heart morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of heart morphogenesis. [GOC:BHF]"}
{"concept_id": "C3270475", "aliases": ["RNA quality control in mitochondria", "RNA surveillance in mitochondria", "aberrant RNA catabolic process in mitochondrion", "aberrant RNA catabolic process in mitochondria", "RNA quality control in mitochondrion"], "types": ["T045"], "canonical_name": "mitochondrial RNA surveillance", "definition": "The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion. [PMID:19864255]"}
{"concept_id": "C3270476", "aliases": ["regulation of parathormone secretion", "regulation of parathyrin secretion", "regulation of PTH secretion"], "types": ["T038"], "canonical_name": "regulation of parathyroid hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of parathyroid hormone secretion. [GOC:obol]"}
{"concept_id": "C3270477", "aliases": ["negative regulation of parathyrin secretion", "negative regulation of PTH secretion", "negative regulation of parathormone secretion"], "types": ["T043"], "canonical_name": "negative regulation of parathyroid hormone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion. [GOC:obol]"}
{"concept_id": "C3270478", "aliases": ["positive regulation of parathormone secretion", "positive regulation of parathyrin secretion", "positive regulation of PTH secretion"], "types": ["T043"], "canonical_name": "positive regulation of parathyroid hormone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion. [GOC:obol]"}
{"concept_id": "C3270479", "aliases": [], "types": ["T038"], "canonical_name": "regulation of steroid hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of steroid hormone secretion. [GOC:sl]"}
{"concept_id": "C3270480", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of steroid hormone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. [GOC:sl]"}
{"concept_id": "C3270481", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of steroid hormone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. [GOC:sl]"}
{"concept_id": "C3270482", "aliases": [], "types": ["T042"], "canonical_name": "regulation of androgen secretion", "definition": "Any process that modulates the frequency, rate or extent of androgen secretion. [GOC:sl]"}
{"concept_id": "C3270483", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of androgen secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion. [GOC:sl]"}
{"concept_id": "C3270484", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of androgen secretion", "definition": "Any process that activates or increases the frequency, rate or extent of androgen secretion. [GOC:sl]"}
{"concept_id": "C3270485", "aliases": ["regulation of androst-4-ene-3,17-dione secretion"], "types": ["T042"], "canonical_name": "regulation of androstenedione secretion", "definition": "Any process that modulates the frequency, rate or extent of androstenedione secretion. [GOC:sl]"}
{"concept_id": "C3270486", "aliases": ["negative regulation of androst-4-ene-3,17-dione secretion"], "types": ["T043"], "canonical_name": "negative regulation of androstenedione secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of androstenedione secretion. [GOC:sl]"}
{"concept_id": "C3270487", "aliases": ["positive regulation of androst-4-ene-3,17-dione secretion"], "types": ["T043"], "canonical_name": "positive regulation of androstenedione secretion", "definition": "Any process that activates or increases the frequency, rate or extent of androstenedione secretion. [GOC:sl]"}
{"concept_id": "C3270488", "aliases": ["regulation of dehydroisoandrosterone secretion", "regulation of 3beta-hydroxyandrost-5-en-17-one secretion", "regulation of DHEA secretion"], "types": ["T042"], "canonical_name": "regulation of dehydroepiandrosterone secretion", "definition": "Any process that modulates the frequency, rate or extent of dehydroepiandrosterone secretion. [GOC:sl]"}
{"concept_id": "C3270489", "aliases": ["negative regulation of dehydroisoandrosterone secretion", "negative regulation of 3beta-hydroxyandrost-5-en-17-one secretion", "negative regulation of DHEA secretion"], "types": ["T043"], "canonical_name": "negative regulation of dehydroepiandrosterone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroepiandrosterone secretion. [GOC:sl]"}
{"concept_id": "C3270490", "aliases": ["positive regulation of DHEA secretion", "positive regulation of 3beta-hydroxyandrost-5-en-17-one secretion", "positive regulation of dehydroisoandrosterone secretion"], "types": ["T043"], "canonical_name": "positive regulation of dehydroepiandrosterone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of dehydroepiandrosterone secretion. [GOC:sl]"}
{"concept_id": "C3270491", "aliases": [], "types": ["T042"], "canonical_name": "regulation of testosterone secretion", "definition": "Any process that modulates the frequency, rate or extent of testosterone secretion. [GOC:sl]"}
{"concept_id": "C3270492", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of testosterone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion. [GOC:sl]"}
{"concept_id": "C3270493", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of testosterone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of testosterone secretion. [GOC:sl]"}
{"concept_id": "C3270494", "aliases": ["regulation of corticosteroid secretion"], "types": ["T042"], "canonical_name": "regulation of corticosteroid hormone secretion", "definition": "Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. [GOC:sl]"}
{"concept_id": "C3270495", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of corticosteroid hormone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion. [GOC:sl]"}
{"concept_id": "C3270496", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of corticosteroid secretion"}
{"concept_id": "C3270497", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of corticosteroid hormone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion. [GOC:sl]"}
{"concept_id": "C3270498", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of corticosteroid secretion"}
{"concept_id": "C3270499", "aliases": [], "types": ["T042"], "canonical_name": "regulation of glucocorticoid secretion", "definition": "Any process that modulates the frequency, rate or extent of glucocorticoid secretion. [GOC:sl]"}
{"concept_id": "C3270500", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glucocorticoid secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion. [GOC:sl]"}
{"concept_id": "C3270501", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glucocorticoid secretion", "definition": "Any process that activates or increases the frequency, rate or extent of glucocorticoid secretion. [GOC:sl]"}
{"concept_id": "C3270502", "aliases": [], "types": ["T042"], "canonical_name": "regulation of corticosterone secretion", "definition": "Any process that modulates the frequency, rate or extent of corticosterone secretion. [GOC:sl]"}
{"concept_id": "C3270503", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of corticosterone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion. [GOC:sl]"}
{"concept_id": "C3270504", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of corticosterone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of corticosterone secretion. [GOC:sl]"}
{"concept_id": "C3270505", "aliases": [], "types": ["T042"], "canonical_name": "regulation of mineralocorticoid secretion", "definition": "Any process that modulates the frequency, rate or extent of mineralocorticoid secretion. [GOC:sl]"}
{"concept_id": "C3270506", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mineralocorticoid secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion. [GOC:sl]"}
{"concept_id": "C3270507", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mineralocorticoid secretion", "definition": "Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion. [GOC:sl]"}
{"concept_id": "C3270508", "aliases": [], "types": ["T042"], "canonical_name": "regulation of aldosterone secretion", "definition": "Any process that modulates the frequency, rate or extent of aldosterone secretion. [GOC:sl]"}
{"concept_id": "C3270509", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of aldosterone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion. [GOC:sl]"}
{"concept_id": "C3270510", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of aldosterone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of aldosterone secretion. [GOC:sl]"}
{"concept_id": "C3270511", "aliases": ["regulation of oestrogen secretion"], "types": ["T042"], "canonical_name": "regulation of estrogen secretion", "definition": "Any process that modulates the frequency, rate or extent of estrogen secretion. [GOC:sl]"}
{"concept_id": "C3270512", "aliases": ["negative regulation of oestrogen secretion"], "types": ["T043"], "canonical_name": "negative regulation of estrogen secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen secretion. [GOC:sl]"}
{"concept_id": "C3270514", "aliases": ["positive regulation of oestrogen secretion"], "types": ["T043"], "canonical_name": "positive regulation of estrogen secretion", "definition": "Any process that activates or increases the frequency, rate or extent of estrogen secretion. [GOC:sl]"}
{"concept_id": "C3270515", "aliases": ["regulation of oestradiol secretion"], "types": ["T042"], "canonical_name": "regulation of estradiol secretion", "definition": "Any process that modulates the frequency, rate or extent of estradiol secretion. [GOC:sl]"}
{"concept_id": "C3270516", "aliases": ["negative regulation of oestradiol secretion"], "types": ["T043"], "canonical_name": "negative regulation of estradiol secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion. [GOC:sl]"}
{"concept_id": "C3270517", "aliases": ["positive regulation of oestradiol secretion"], "types": ["T043"], "canonical_name": "positive regulation of estradiol secretion", "definition": "Any process that activates or increases the frequency, rate or extent of estradiol secretion. [GOC:sl]"}
{"concept_id": "C3270518", "aliases": ["regulation of folliculin secretion", "regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion"], "types": ["T042"], "canonical_name": "regulation of estrone secretion", "definition": "Any process that modulates the frequency, rate or extent of estrone secretion. [GOC:sl]"}
{"concept_id": "C3270519", "aliases": ["negative regulation of folliculin secretion", "negative regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion"], "types": ["T043"], "canonical_name": "negative regulation of estrone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of estrone secretion. [GOC:sl]"}
{"concept_id": "C3270520", "aliases": ["positive regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion", "positive regulation of folliculin secretion"], "types": ["T043"], "canonical_name": "positive regulation of estrone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of estrone secretion. [GOC:sl]"}
{"concept_id": "C3270521", "aliases": [], "types": ["T042"], "canonical_name": "regulation of progesterone secretion", "definition": "Any process that modulates the frequency, rate or extent of progesterone secretion. [GOC:sl]"}
{"concept_id": "C3270522", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of progesterone secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion. [GOC:sl]"}
{"concept_id": "C3270523", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of progesterone secretion", "definition": "Any process that activates or increases the frequency, rate or extent of progesterone secretion. [GOC:sl]"}
{"concept_id": "C3270524", "aliases": ["regulation of histone H4 acetylation involved in DNA damage response", "regulation of histone H4 acetylation involved in cellular response to DNA damage stimulus", "regulation of histone H4 acetylation involved in response to genotoxic stress", "regulation of histone H4 acetylation involved in cellular DNA damage response", "regulation of histone H4 acetylation involved in response to DNA damage"], "types": ["T043"], "canonical_name": "regulation of histone H4 acetylation involved in response to DNA damage stimulus", "definition": "Any process that modulates the frequency, rate or extent of histone H4 acetylation involved in response to DNA damage stimulus. [GOC:mah]"}
{"concept_id": "C3270525", "aliases": ["regulation of glyoxylate bypass"], "types": ["T043"], "canonical_name": "regulation of glyoxylate cycle", "definition": "Any process that modulates the frequency, rate or extent of glyoxylate cycle. [GOC:dgf]"}
{"concept_id": "C3270526", "aliases": ["negative regulation of glyoxylate bypass"], "types": ["T043"], "canonical_name": "negative regulation of glyoxylate cycle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glyoxylate cycle. [GOC:dgf]"}
{"concept_id": "C3270527", "aliases": ["positive regulation of glyoxylate bypass"], "types": ["T044"], "canonical_name": "positive regulation of glyoxylate cycle", "definition": "Any process that activates or increases the frequency, rate or extent of glyoxylate cycle. [GOC:dgf]"}
{"concept_id": "C3270528", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of oligopeptide transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport. [GOC:obol]"}
{"concept_id": "C3270529", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of oligopeptide transport", "definition": "Any process that activates or increases the frequency, rate or extent of oligopeptide transport. [GOC:obol]"}
{"concept_id": "C3270530", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of dipeptide transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport. [GOC:obol]"}
{"concept_id": "C3270531", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of dipeptide transport", "definition": "Any process that activates or increases the frequency, rate or extent of dipeptide transport. [GOC:obol]"}
{"concept_id": "C3270532", "aliases": ["regulation of starch breakdown", "regulation of starch degradation", "regulation of starch catabolism"], "types": ["T044"], "canonical_name": "regulation of starch catabolic process", "definition": "Any process that modulates the frequency, rate or extent of starch catabolic process. [GOC:obol]"}
{"concept_id": "C3270533", "aliases": ["negative regulation of starch degradation", "negative regulation of starch breakdown", "negative regulation of starch catabolism"], "types": ["T044"], "canonical_name": "negative regulation of starch catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of starch catabolic process. [GOC:obol]"}
{"concept_id": "C3270534", "aliases": ["positive regulation of starch degradation", "positive regulation of starch catabolism", "positive regulation of starch breakdown"], "types": ["T044"], "canonical_name": "positive regulation of starch catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of starch catabolic process. [GOC:obol]"}
{"concept_id": "C3270535", "aliases": ["glucomannan catabolism"], "types": ["T044"], "canonical_name": "glucomannan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a glucomannan. [GOC:mengo_curators]"}
{"concept_id": "C3270536", "aliases": ["galactoglucomannan catabolism"], "types": ["T044"], "canonical_name": "galactoglucomannan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a galactoglucomannan. [GOC:mengo_curators]"}
{"concept_id": "C3270537", "aliases": ["glucuronoxylan catabolism"], "types": ["T044"], "canonical_name": "glucuronoxylan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a glucuronoxylan. [GOC:mengo_curators]"}
{"concept_id": "C3270538", "aliases": ["glucuronoarabinoxylan catabolism"], "types": ["T044"], "canonical_name": "glucuronoarabinoxylan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a glucuronoarabinoxylan. [GOC:mengo_curators]"}
{"concept_id": "C3270539", "aliases": ["arabinoxylan catabolism"], "types": ["T044"], "canonical_name": "arabinoxylan-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an arabinoxylan. [GOC:mengo_curators]"}
{"concept_id": "C3270540", "aliases": ["cellodextrin metabolism"], "types": ["T044"], "canonical_name": "cellodextrin metabolic process", "definition": "The chemical reactions and pathways involving a cellodextrin. [GOC:obol]"}
{"concept_id": "C3270541", "aliases": ["cellodextrin catabolism"], "types": ["T044"], "canonical_name": "cellodextrin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a cellodextrin. [GOC:mengo_curators]"}
{"concept_id": "C3270542", "aliases": ["cellobiose metabolism"], "types": ["T044"], "canonical_name": "cellobiose metabolic process", "definition": "The chemical reactions and pathways involving a cellobiose. [GOC:mengo_curators]"}
{"concept_id": "C3270543", "aliases": ["cellobiose catabolism"], "types": ["T044"], "canonical_name": "cellobiose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a cellobiose. [GOC:mengo_curators]"}
{"concept_id": "C3270544", "aliases": ["cellotriose metabolism"], "types": ["T044"], "canonical_name": "cellotriose metabolic process", "definition": "The chemical reactions and pathways involving a cellotriose. [GOC:mengo_curators]"}
{"concept_id": "C3270545", "aliases": ["cellotriose catabolism"], "types": ["T044"], "canonical_name": "cellotriose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a cellotriose. [GOC:mengo_curators]"}
{"concept_id": "C3270546", "aliases": ["hemicellulose catabolism"], "types": ["T044"], "canonical_name": "hemicellulose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a hemicellulose. [GOC:mengo_curators]"}
{"concept_id": "C3270547", "aliases": ["Amylopectin metabolism"], "types": ["T044"], "canonical_name": "amylopectin metabolic process", "definition": "The chemical reactions and pathways involving an amylopectin. [GOC:mengo_curators]"}
{"concept_id": "C3270548", "aliases": ["Amylopectin catabolism"], "types": ["T044"], "canonical_name": "amylopectin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an amylopectin. [GOC:mengo_curators]"}
{"concept_id": "C3270549", "aliases": ["regulation of glucomannan catabolism"], "types": ["T040"], "canonical_name": "regulation of glucomannan catabolic process", "definition": "Any process that modulates the frequency, rate or extent of glucomannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270550", "aliases": ["xyloglucan catabolism"], "types": ["T044"], "canonical_name": "xyloglucan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a xyloglucan. [GOC:mengo_curators]"}
{"concept_id": "C3270551", "aliases": ["cyclodextrin metabolism"], "types": ["T044"], "canonical_name": "cyclodextrin metabolic process", "definition": "The chemical reactions and pathways involving a cyclodextrin. [GOC:mengo_curators]"}
{"concept_id": "C3270552", "aliases": ["cyclodextrin catabolism"], "types": ["T044"], "canonical_name": "cyclodextrin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a cyclodextrin. [GOC:mengo_curators]"}
{"concept_id": "C3270553", "aliases": ["cellooligosaccharide metabolism"], "types": ["T044"], "canonical_name": "cellooligosaccharide metabolic process", "definition": "The chemical reactions and pathways involving a cellooligosaccharide. [GOC:mengo_curators]"}
{"concept_id": "C3270554", "aliases": ["cellooligosaccharide catabolism"], "types": ["T044"], "canonical_name": "cellooligosaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a cellooligosaccharide. [GOC:mengo_curators]"}
{"concept_id": "C3270555", "aliases": ["regulation of starch metabolism"], "types": ["T043"], "canonical_name": "regulation of starch metabolic process", "definition": "Any process that modulates the frequency, rate or extent of starch metabolic process. [GOC:obol]"}
{"concept_id": "C3270556", "aliases": ["negative regulation of starch metabolism"], "types": ["T044"], "canonical_name": "negative regulation of starch metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of starch metabolic process. [GOC:obol]"}
{"concept_id": "C3270557", "aliases": ["positive regulation of starch metabolism"], "types": ["T044"], "canonical_name": "positive regulation of starch metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of starch metabolic process. [GOC:obol]"}
{"concept_id": "C3270558", "aliases": ["negative regulation of glucomannan catabolism"], "types": ["T043"], "canonical_name": "negative regulation of glucomannan catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucomannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270559", "aliases": ["positive regulation of glucomannan catabolism"], "types": ["T044"], "canonical_name": "positive regulation of glucomannan catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of glucomannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270560", "aliases": ["regulation of sterol uptake", "regulation of sterol influx"], "types": ["T044"], "canonical_name": "regulation of sterol import", "definition": "Any process that modulates the frequency, rate or extent of sterol import. [GOC:obol]"}
{"concept_id": "C3270561", "aliases": ["negative regulation of sterol influx", "negative regulation of sterol uptake"], "types": ["T044"], "canonical_name": "negative regulation of sterol import", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sterol import. [GOC:obol]"}
{"concept_id": "C3270562", "aliases": ["positive regulation of sterol uptake", "positive regulation of sterol influx"], "types": ["T044"], "canonical_name": "positive regulation of sterol import", "definition": "Any process that activates or increases the frequency, rate or extent of sterol import. [GOC:obol]"}
{"concept_id": "C3270563", "aliases": ["regulation of galactoglucomannan catabolism"], "types": ["T040"], "canonical_name": "regulation of galactoglucomannan catabolic process", "definition": "Any process that modulates the frequency, rate or extent of galactoglucomannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270564", "aliases": ["negative regulation of galactoglucomannan catabolism"], "types": ["T043"], "canonical_name": "negative regulation of galactoglucomannan catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of galactoglucomannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270565", "aliases": ["positive regulation of galactoglucomannan catabolism"], "types": ["T044"], "canonical_name": "positive regulation of galactoglucomannan catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of galactoglucomannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270566", "aliases": ["regulation of glucuronoxylan catabolism"], "types": ["T040"], "canonical_name": "regulation of glucuronoxylan catabolic process", "definition": "Any process that modulates the frequency, rate or extent of glucuronoxylan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270567", "aliases": ["negative regulation of glucuronoxylan catabolism"], "types": ["T040"], "canonical_name": "negative regulation of glucuronoxylan catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoxylan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270568", "aliases": ["positive regulation of glucuronoxylan catabolism"], "types": ["T040"], "canonical_name": "positive regulation of glucuronoxylan catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of glucuronoxylan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270569", "aliases": ["regulation of glucuronoarabinoxylan catabolism"], "types": ["T040"], "canonical_name": "regulation of glucuronoarabinoxylan catabolic process", "definition": "Any process that modulates the frequency, rate or extent of glucuronoarabinoxylan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270570", "aliases": ["negative regulation of glucuronoarabinoxylan catabolism"], "types": ["T040"], "canonical_name": "negative regulation of glucuronoarabinoxylan catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoarabinoxylan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270571", "aliases": ["positive regulation of glucuronoarabinoxylan catabolism"], "types": ["T040"], "canonical_name": "positive regulation of glucuronoarabinoxylan catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of glucuronoarabinoxylan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270572", "aliases": ["regulation of arabinoxylan catabolism"], "types": ["T040"], "canonical_name": "regulation of arabinoxylan-containing compound catabolic process", "definition": "Any process that modulates the frequency, rate or extent of arabinoxylan-containing compound catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270573", "aliases": ["negative regulation of arabinoxylan catabolism"], "types": ["T040"], "canonical_name": "negative regulation of arabinoxylan-containing compound catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of arabinoxylan-containing compound catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270574", "aliases": ["positive regulation of arabinoxylan catabolism"], "types": ["T040"], "canonical_name": "positive regulation of arabinoxylan-containing compound catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of arabinoxylan-containing compound catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270575", "aliases": ["regulation of cellodextrin metabolism"], "types": ["T043"], "canonical_name": "regulation of cellodextrin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellodextrin metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270576", "aliases": ["negative regulation of cellodextrin metabolism"], "types": ["T044"], "canonical_name": "negative regulation of cellodextrin metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270577", "aliases": ["positive regulation of cellodextrin metabolism"], "types": ["T044"], "canonical_name": "positive regulation of cellodextrin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellodextrin metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270578", "aliases": ["regulation of cellodextrin catabolism"], "types": ["T043"], "canonical_name": "regulation of cellodextrin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellodextrin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270579", "aliases": ["negative regulation of cellodextrin catabolism"], "types": ["T044"], "canonical_name": "negative regulation of cellodextrin catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270580", "aliases": ["positive regulation of cellodextrin catabolism"], "types": ["T044"], "canonical_name": "positive regulation of cellodextrin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellodextrin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270581", "aliases": ["regulation of cellobiose metabolism"], "types": ["T043"], "canonical_name": "regulation of cellobiose metabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellobiose metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270582", "aliases": ["negative regulation of cellobiose metabolism"], "types": ["T043"], "canonical_name": "negative regulation of cellobiose metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270583", "aliases": ["positive regulation of cellobiose metabolism"], "types": ["T044"], "canonical_name": "positive regulation of cellobiose metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellobiose metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270584", "aliases": ["regulation of cellotriose metabolism"], "types": ["T043"], "canonical_name": "regulation of cellotriose metabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellotriose metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270585", "aliases": ["negative regulation of cellotriose metabolism"], "types": ["T044"], "canonical_name": "negative regulation of cellotriose metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270586", "aliases": ["positive regulation of cellotriose metabolism"], "types": ["T044"], "canonical_name": "positive regulation of cellotriose metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellotriose metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270587", "aliases": ["regulation of cellotriose catabolism"], "types": ["T043"], "canonical_name": "regulation of cellotriose catabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellotriose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270588", "aliases": ["negative regulation of cellotriose catabolism"], "types": ["T044"], "canonical_name": "negative regulation of cellotriose catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270589", "aliases": ["positive regulation of cellotriose catabolism"], "types": ["T044"], "canonical_name": "positive regulation of cellotriose catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellotriose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270590", "aliases": ["regulation of plant-type cell wall polysaccharide breakdown"], "types": ["T044"], "canonical_name": "regulation of plant-type cell wall cellulose catabolic process", "definition": "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270591", "aliases": ["negative regulation of plant-type cell wall polysaccharide breakdown"], "types": ["T044"], "canonical_name": "negative regulation of plant-type cell wall cellulose catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270592", "aliases": ["positive regulation of plant-type cell wall polysaccharide breakdown"], "types": ["T044"], "canonical_name": "positive regulation of plant-type cell wall cellulose catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270593", "aliases": ["regulation of Amylopectin metabolism"], "types": ["T043"], "canonical_name": "regulation of amylopectin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of amylopectin metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270594", "aliases": ["negative regulation of Amylopectin metabolism"], "types": ["T044"], "canonical_name": "negative regulation of amylopectin metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270595", "aliases": ["positive regulation of Amylopectin metabolism"], "types": ["T044"], "canonical_name": "positive regulation of amylopectin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of amylopectin metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270596", "aliases": ["regulation of Amylopectin catabolism"], "types": ["T044"], "canonical_name": "regulation of amylopectin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of amylopectin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270597", "aliases": ["negative regulation of Amylopectin catabolism"], "types": ["T044"], "canonical_name": "negative regulation of amylopectin catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270598", "aliases": ["positive regulation of Amylopectin catabolism"], "types": ["T044"], "canonical_name": "positive regulation of amylopectin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of amylopectin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270599", "aliases": ["regulation of xyloglucan metabolism"], "types": ["T043"], "canonical_name": "regulation of xyloglucan metabolic process", "definition": "Any process that modulates the frequency, rate or extent of xyloglucan metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270600", "aliases": ["negative regulation of xyloglucan metabolism"], "types": ["T044"], "canonical_name": "negative regulation of xyloglucan metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270601", "aliases": ["positive regulation of xyloglucan metabolism"], "types": ["T044"], "canonical_name": "positive regulation of xyloglucan metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of xyloglucan metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270602", "aliases": ["regulation of xyloglucan catabolism"], "types": ["T043"], "canonical_name": "regulation of xyloglucan catabolic process", "definition": "Any process that modulates the frequency, rate or extent of xyloglucan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270603", "aliases": ["negative regulation of xyloglucan catabolism"], "types": ["T044"], "canonical_name": "negative regulation of xyloglucan catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270604", "aliases": ["positive regulation of xyloglucan catabolism"], "types": ["T044"], "canonical_name": "positive regulation of xyloglucan catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of xyloglucan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270605", "aliases": ["regulation of cyclodextrin metabolism"], "types": ["T043"], "canonical_name": "regulation of cyclodextrin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of cyclodextrin metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270606", "aliases": ["negative regulation of cyclodextrin metabolism"], "types": ["T044"], "canonical_name": "negative regulation of cyclodextrin metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270607", "aliases": ["positive regulation of cyclodextrin metabolism"], "types": ["T044"], "canonical_name": "positive regulation of cyclodextrin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cyclodextrin metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270608", "aliases": ["regulation of cyclodextrin catabolism"], "types": ["T043"], "canonical_name": "regulation of cyclodextrin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of cyclodextrin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270609", "aliases": ["negative regulation of cyclodextrin catabolism"], "types": ["T044"], "canonical_name": "negative regulation of cyclodextrin catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270610", "aliases": ["positive regulation of cyclodextrin catabolism"], "types": ["T044"], "canonical_name": "positive regulation of cyclodextrin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cyclodextrin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270611", "aliases": ["regulation of cellooligosaccharide metabolism"], "types": ["T043"], "canonical_name": "regulation of cellooligosaccharide metabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellooligosaccharide metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270612", "aliases": ["negative regulation of cellooligosaccharide metabolism"], "types": ["T043"], "canonical_name": "negative regulation of cellooligosaccharide metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270613", "aliases": ["positive regulation of cellooligosaccharide metabolism"], "types": ["T043"], "canonical_name": "positive regulation of cellooligosaccharide metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide metabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270614", "aliases": ["regulation of cellooligosaccharide catabolism"], "types": ["T043"], "canonical_name": "regulation of cellooligosaccharide catabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellooligosaccharide catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270615", "aliases": ["negative regulation of cellooligosaccharide catabolism"], "types": ["T044"], "canonical_name": "negative regulation of cellooligosaccharide catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270616", "aliases": ["positive regulation of cellooligosaccharide catabolism"], "types": ["T044"], "canonical_name": "positive regulation of cellooligosaccharide catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270617", "aliases": ["regulation of cell wall polysaccharide breakdown"], "types": ["T044"], "canonical_name": "regulation of cell wall polysaccharide catabolic process", "definition": "Any process that modulates the frequency, rate or extent of cell wall polysaccharide catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270618", "aliases": ["negative regulation of cell wall polysaccharide breakdown"], "types": ["T044"], "canonical_name": "negative regulation of cell wall polysaccharide catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall polysaccharide catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270619", "aliases": ["positive regulation of cell wall polysaccharide breakdown"], "types": ["T044"], "canonical_name": "positive regulation of cell wall polysaccharide catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cell wall polysaccharide catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270620", "aliases": ["positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity"], "types": ["T044"], "canonical_name": "positive regulation of AMPA receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity. [PMID:21423165]"}
{"concept_id": "C3270621", "aliases": ["regulation of glucose detection"], "types": ["T039"], "canonical_name": "regulation of detection of glucose", "definition": "Any process that modulates the frequency, rate or extent of detection of glucose. [GOC:BHF]"}
{"concept_id": "C3270622", "aliases": [], "types": ["T039"], "canonical_name": "regulation of glucose perception"}
{"concept_id": "C3270623", "aliases": [], "types": ["T039"], "canonical_name": "regulation of glucose sensing"}
{"concept_id": "C3270624", "aliases": ["negative regulation of glucose detection"], "types": ["T038"], "canonical_name": "negative regulation of detection of glucose", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of detection of glucose. [GOC:BHF]"}
{"concept_id": "C3270625", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of glucose perception"}
{"concept_id": "C3270626", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of glucose sensing"}
{"concept_id": "C3270627", "aliases": ["positive regulation of glucose detection"], "types": ["T038"], "canonical_name": "positive regulation of detection of glucose", "definition": "Any process that activates or increases the frequency, rate or extent of detection of glucose. [GOC:BHF]"}
{"concept_id": "C3270628", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of glucose perception"}
{"concept_id": "C3270629", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of glucose sensing"}
{"concept_id": "C3270630", "aliases": ["regulation of pro-B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "regulation of pro-B cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of pro-B cell differentiation. [GOC:obol]"}
{"concept_id": "C3270631", "aliases": ["negative regulation of pro-B cell development", "negative regulation of pro-B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of pro-B cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation. [GOC:obol]"}
{"concept_id": "C3270632", "aliases": ["positive regulation of pro-B lymphocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of pro-B cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of pro-B cell differentiation. [GOC:obol]"}
{"concept_id": "C3270647", "aliases": [], "types": ["T043"], "canonical_name": "regulation of forebrain neuron differentiation", "definition": "Any process that modulates the frequency, rate or extent of forebrain neuron differentiation. [GOC:obol]"}
{"concept_id": "C3270648", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of forebrain neuron differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation. [GOC:obol]"}
{"concept_id": "C3270649", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of forebrain neuron differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation. [GOC:obol]"}
{"concept_id": "C3270650", "aliases": ["regulation of inner ear hair cell differentiation"], "types": ["T043"], "canonical_name": "regulation of inner ear receptor cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of inner ear receptor cell differentiation. [GOC:obol]"}
{"concept_id": "C3270651", "aliases": ["negative regulation of inner ear hair cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of inner ear receptor cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation. [GOC:obol]"}
{"concept_id": "C3270652", "aliases": ["positive regulation of inner ear hair cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of inner ear receptor cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation. [GOC:obol]"}
{"concept_id": "C3270653", "aliases": ["regulation of adenosine triphosphate citrate lyase activity", "regulation of ATP citrate (pro-S)-lyase activity", "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity", "regulation of ATP-citrate (pro-S)-lyase activity", "regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity", "regulation of ATP-citric lyase activity", "regulation of ATP-citrate (pro-S-)-lyase activity", "regulation of citrate-ATP lyase activity", "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)"], "types": ["T044"], "canonical_name": "regulation of ATP citrate synthase activity", "definition": "Any process that modulates the frequency, rate or extent of ATP citrate synthase activity. [GOC:BHF]"}
{"concept_id": "C3270654", "aliases": [], "types": ["T044"], "canonical_name": "regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]"}
{"concept_id": "C3270655", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)"}
{"concept_id": "C3270656", "aliases": [], "types": ["T044"], "canonical_name": "regulation of citrate cleavage enzyme activity"}
{"concept_id": "C3270657", "aliases": [], "types": ["T044"], "canonical_name": "regulation of citric cleavage enzyme activity"}
{"concept_id": "C3270658", "aliases": ["negative regulation of citrate-ATP lyase activity", "negative regulation of ATP citrate (pro-S)-lyase activity", "negative regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity", "negative regulation of adenosine triphosphate citrate lyase activity", "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity", "negative regulation of ATP-citric lyase activity", "negative regulation of ATP-citrate (pro-S-)-lyase activity", "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)", "negative regulation of ATP-citrate (pro-S)-lyase activity"], "types": ["T044"], "canonical_name": "negative regulation of ATP citrate synthase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity. [GOC:BHF]"}
{"concept_id": "C3270659", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]"}
{"concept_id": "C3270660", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)"}
{"concept_id": "C3270661", "aliases": ["negative regulation of citric cleavage enzyme activity"], "types": ["T044"], "canonical_name": "negative regulation of citrate cleavage enzyme activity"}
{"concept_id": "C3270662", "aliases": ["positive regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity", "positive regulation of ATP-citric lyase activity", "positive regulation of adenosine triphosphate citrate lyase activity", "positive regulation of ATP citrate (pro-S)-lyase activity", "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)", "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity", "positive regulation of ATP-citrate (pro-S-)-lyase activity", "positive regulation of citrate-ATP lyase activity", "positive regulation of ATP-citrate (pro-S)-lyase activity"], "types": ["T044"], "canonical_name": "positive regulation of ATP citrate synthase activity", "definition": "Any process that activates or increases the frequency, rate or extent of ATP citrate synthase activity. [GOC:BHF]"}
{"concept_id": "C3270663", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]"}
{"concept_id": "C3270664", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)"}
{"concept_id": "C3270665", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of citrate cleavage enzyme activity"}
{"concept_id": "C3270666", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of citric cleavage enzyme activity"}
{"concept_id": "C3270667", "aliases": ["negative regulation of behavioural fear response"], "types": ["T040"], "canonical_name": "negative regulation of behavioral fear response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of behavioral fear response. [GOC:obol]"}
{"concept_id": "C3270668", "aliases": ["positive regulation of behavioural fear response"], "types": ["T040"], "canonical_name": "positive regulation of behavioral fear response", "definition": "Any process that activates or increases the frequency, rate or extent of behavioral fear response. [GOC:obol]"}
{"concept_id": "C3270669", "aliases": ["regulation of hemicellulose catabolism"], "types": ["T040"], "canonical_name": "regulation of hemicellulose catabolic process", "definition": "Any process that modulates the frequency, rate or extent of hemicellulose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270670", "aliases": ["negative regulation of hemicellulose catabolism"], "types": ["T044"], "canonical_name": "negative regulation of hemicellulose catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hemicellulose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270671", "aliases": ["positive regulation of hemicellulose catabolism"], "types": ["T044"], "canonical_name": "positive regulation of hemicellulose catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of hemicellulose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270672", "aliases": [], "types": ["T040"], "canonical_name": "regulation of galactomannan catabolic process", "definition": "Any process that modulates the frequency, rate or extent of galactomannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270673", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of galactomannan catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of galactomannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270674", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of galactomannan catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of galactomannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270675", "aliases": ["regulation of mannan breakdown", "regulation of mannan catabolism", "regulation of mannan degradation"], "types": ["T043"], "canonical_name": "regulation of mannan catabolic process", "definition": "Any process that modulates the frequency, rate or extent of mannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270676", "aliases": ["negative regulation of mannan degradation", "negative regulation of mannan catabolism", "negative regulation of mannan breakdown"], "types": ["T043"], "canonical_name": "negative regulation of mannan catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270677", "aliases": ["positive regulation of mannan breakdown", "positive regulation of mannan degradation", "positive regulation of mannan catabolism"], "types": ["T044"], "canonical_name": "positive regulation of mannan catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of mannan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270678", "aliases": ["regulation of cellulose degradation", "regulation of cellulose catabolism", "regulation of cellulose breakdown"], "types": ["T043"], "canonical_name": "regulation of cellulose catabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellulose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270679", "aliases": ["negative regulation of cellulose degradation", "negative regulation of cellulose breakdown", "negative regulation of cellulose catabolism"], "types": ["T044"], "canonical_name": "negative regulation of cellulose catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270680", "aliases": ["positive regulation of cellulose degradation", "positive regulation of cellulose catabolism", "positive regulation of cellulose breakdown"], "types": ["T044"], "canonical_name": "positive regulation of cellulose catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellulose catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270681", "aliases": ["regulation of xylan breakdown", "regulation of xylan catabolism", "regulation of xylan degradation"], "types": ["T040"], "canonical_name": "regulation of xylan catabolic process", "definition": "Any process that modulates the frequency, rate or extent of xylan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270682", "aliases": ["negative regulation of xylan degradation", "negative regulation of xylan breakdown", "negative regulation of xylan catabolism"], "types": ["T044"], "canonical_name": "negative regulation of xylan catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of xylan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270683", "aliases": ["positive regulation of xylan catabolism", "positive regulation of xylan breakdown", "positive regulation of xylan degradation"], "types": ["T044"], "canonical_name": "positive regulation of xylan catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of xylan catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270684", "aliases": ["regulation of pectin catabolism", "regulation of pectin breakdown", "regulation of pectin degradation"], "types": ["T043"], "canonical_name": "regulation of pectin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of pectin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270685", "aliases": ["negative regulation of pectin degradation", "negative regulation of pectin catabolism", "negative regulation of pectin breakdown"], "types": ["T044"], "canonical_name": "negative regulation of pectin catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pectin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270686", "aliases": ["positive regulation of pectin catabolism", "positive regulation of pectin breakdown", "positive regulation of pectin degradation"], "types": ["T044"], "canonical_name": "positive regulation of pectin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of pectin catabolic process. [GOC:mengo_curators]"}
{"concept_id": "C3270687", "aliases": ["regulation of cellulose synthesis", "regulation of cellulose biosynthesis", "regulation of cellulose formation", "regulation of cellulose anabolism"], "types": ["T043"], "canonical_name": "regulation of cellulose biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of cellulose biosynthetic process. [GOC:mengo_curators]"}
{"concept_id": "C3270688", "aliases": ["negative regulation of cellulose formation", "negative regulation of cellulose biosynthesis", "negative regulation of cellulose anabolism", "negative regulation of cellulose synthesis"], "types": ["T043"], "canonical_name": "negative regulation of cellulose biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose biosynthetic process. [GOC:mengo_curators]"}
{"concept_id": "C3270689", "aliases": ["positive regulation of cellulose anabolism", "positive regulation of cellulose formation", "positive regulation of cellulose biosynthesis", "positive regulation of cellulose synthesis"], "types": ["T044"], "canonical_name": "positive regulation of cellulose biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellulose biosynthetic process. [GOC:mengo_curators]"}
{"concept_id": "C3270690", "aliases": ["regulation of cell wall cellulose biosynthesis"], "types": ["T043"], "canonical_name": "regulation of plant-type cell wall cellulose biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process. [GOC:mengo_curators]"}
{"concept_id": "C3270691", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cellulose biosynthesis during cell wall biosynthesis"}
{"concept_id": "C3270692", "aliases": ["negative regulation of cell wall cellulose biosynthesis"], "types": ["T043"], "canonical_name": "negative regulation of plant-type cell wall cellulose biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process. [GOC:mengo_curators]"}
{"concept_id": "C3270693", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellulose biosynthesis during cell wall biosynthesis"}
{"concept_id": "C3270694", "aliases": ["positive regulation of cell wall cellulose biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of plant-type cell wall cellulose biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process. [GOC:mengo_curators]"}
{"concept_id": "C3270695", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cellulose biosynthesis during cell wall biosynthesis"}
{"concept_id": "C3270696", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell differentiation involved in renal system development", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]"}
{"concept_id": "C3270697", "aliases": ["mesenchymal cell differentiation involved in urinary tract development"], "types": ["T043"], "canonical_name": "mesenchymal cell differentiation involved in urinary system development"}
{"concept_id": "C3270698", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell proliferation involved in renal tubule morphogenesis", "definition": "Any epithelial cell proliferation that is involved in renal tubule morphogenesis. [GOC:obol]"}
{"concept_id": "C3270699", "aliases": [], "types": ["T043"], "canonical_name": "regulation of skeletal muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. [GOC:obol]"}
{"concept_id": "C3270700", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of skeletal muscle cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. [GOC:obol]"}
{"concept_id": "C3270701", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of skeletal muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. [GOC:obol]"}
{"concept_id": "C3270702", "aliases": ["regulation of retrograde axonal transport"], "types": ["T043"], "canonical_name": "regulation of retrograde axon cargo transport", "definition": "Any process that modulates the frequency, rate or extent of retrograde axon cargo transport. [GOC:obol]"}
{"concept_id": "C3270703", "aliases": ["negative regulation of retrograde axonal transport"], "types": ["T043"], "canonical_name": "negative regulation of retrograde axon cargo transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport. [GOC:obol]"}
{"concept_id": "C3270704", "aliases": ["positive regulation of retrograde axonal transport"], "types": ["T043"], "canonical_name": "positive regulation of retrograde axon cargo transport", "definition": "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport. [GOC:obol]"}
{"concept_id": "C3270705", "aliases": ["regulation of cellular DNA damage response", "regulation of cellular response to DNA damage stimulus", "regulation of DNA damage response", "regulation of response to genotoxic stress"], "types": ["T043"], "canonical_name": "regulation of response to DNA damage stimulus", "definition": "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. [GOC:obol]"}
{"concept_id": "C3270706", "aliases": ["negative regulation of response to genotoxic stress", "negative regulation of DNA damage response", "negative regulation of cellular response to DNA damage stimulus", "negative regulation of cellular DNA damage response"], "types": ["T043"], "canonical_name": "negative regulation of response to DNA damage stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. [GOC:obol]"}
{"concept_id": "C3270707", "aliases": ["positive regulation of DNA damage response", "positive regulation of cellular DNA damage response", "positive regulation of cellular response to DNA damage stimulus", "positive regulation of response to genotoxic stress"], "types": ["T043"], "canonical_name": "positive regulation of response to DNA damage stimulus", "definition": "Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. [GOC:obol]"}
{"concept_id": "C3270708", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to drug", "definition": "Any process that modulates the frequency, rate or extent of response to drug. [GOC:obol]"}
{"concept_id": "C3270709", "aliases": [], "types": ["T039"], "canonical_name": "regulation of drug resistance"}
{"concept_id": "C3270710", "aliases": [], "types": ["T039"], "canonical_name": "regulation of drug susceptibility/resistance"}
{"concept_id": "C3270711", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of response to drug", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to drug. [GOC:obol]"}
{"concept_id": "C3270712", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of drug resistance"}
{"concept_id": "C3270713", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of drug susceptibility/resistance"}
{"concept_id": "C3270714", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of response to drug", "definition": "Any process that activates or increases the frequency, rate or extent of response to drug. [GOC:obol]"}
{"concept_id": "C3270715", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of drug resistance"}
{"concept_id": "C3270716", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of drug susceptibility/resistance"}
{"concept_id": "C3270717", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelial cell chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. [GOC:BHF]"}
{"concept_id": "C3270718", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis. [GOC:BHF]"}
{"concept_id": "C3270719", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endothelial cell chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. [GOC:BHF]"}
{"concept_id": "C3270720", "aliases": ["regulation of cellular glucuronoside biosynthesis", "regulation of cellular glucuronide biosynthetic process", "regulation of cellular glucuronoside biosynthetic process", "regulation of cellular glucuronide biosynthesis"], "types": ["T043"], "canonical_name": "regulation of cellular glucuronidation", "definition": "Any process that modulates the frequency, rate or extent of cellular glucuronidation. [GOC:BHF]"}
{"concept_id": "C3270721", "aliases": ["negative regulation of cellular glucuronide biosynthetic process", "negative regulation of cellular glucuronide biosynthesis", "negative regulation of cellular glucuronoside biosynthetic process", "negative regulation of cellular glucuronoside biosynthesis"], "types": ["T043"], "canonical_name": "negative regulation of cellular glucuronidation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular glucuronidation. [GOC:BHF]"}
{"concept_id": "C3270722", "aliases": ["positive regulation of cellular glucuronoside biosynthesis", "positive regulation of cellular glucuronide biosynthesis", "positive regulation of cellular glucuronide biosynthetic process", "positive regulation of cellular glucuronoside biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of cellular glucuronidation", "definition": "Any process that activates or increases the frequency, rate or extent of cellular glucuronidation. [GOC:BHF]"}
{"concept_id": "C3270723", "aliases": ["regulation of NHEJ"], "types": ["T045"], "canonical_name": "regulation of double-strand break repair via nonhomologous end joining", "definition": "Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining. [GOC:obol]"}
{"concept_id": "C3270724", "aliases": ["negative regulation of NHEJ"], "types": ["T043"], "canonical_name": "negative regulation of double-strand break repair via nonhomologous end joining", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining. [GOC:obol]"}
{"concept_id": "C3270725", "aliases": ["positive regulation of NHEJ"], "types": ["T043"], "canonical_name": "positive regulation of double-strand break repair via nonhomologous end joining", "definition": "Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining. [GOC:obol]"}
{"concept_id": "C3270726", "aliases": [], "types": ["T043"], "canonical_name": "regulation of tongue muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation. [GOC:obol]"}
{"concept_id": "C3270727", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of tongue muscle cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation. [GOC:obol]"}
{"concept_id": "C3270728", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of tongue muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation. [GOC:obol]"}
{"concept_id": "C3270729", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to drug", "definition": "Any process that modulates the frequency, rate or extent of cellular response to drug. [GOC:obol]"}
{"concept_id": "C3270730", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular response to drug", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to drug. [GOC:obol]"}
{"concept_id": "C3270731", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cellular response to drug", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to drug. [GOC:obol]"}
{"concept_id": "C3270733", "aliases": ["negative regulation of cytokinetic cell separation"], "types": ["T043"], "canonical_name": "negative regulation of septum digestion after cytokinesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. [GOC:mtg_cell_cycle, GOC:obol]"}
{"concept_id": "C3270734", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cytokinetic cell separation"}
{"concept_id": "C3270735", "aliases": ["regulation of integrin-mediated signalling pathway"], "types": ["T044"], "canonical_name": "regulation of integrin-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3270736", "aliases": ["negative regulation of integrin-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of integrin-mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3270737", "aliases": ["positive regulation of integrin-mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of integrin-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway. [GOC:obol]"}
{"concept_id": "C3270738", "aliases": ["regulation of G1/S transition checkpoint"], "types": ["T038"], "canonical_name": "regulation of G1/S checkpoint"}
{"concept_id": "C3270739", "aliases": ["negative regulation of G1/S transition checkpoint"], "types": ["T043"], "canonical_name": "negative regulation of G1/S checkpoint"}
{"concept_id": "C3270740", "aliases": ["regulation of tenocyte differentiation", "regulation of muscle attachment cell differentiation"], "types": ["T043"], "canonical_name": "regulation of tendon cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of tendon cell differentiation. [GOC:obol]"}
{"concept_id": "C3270741", "aliases": ["negative regulation of muscle attachment cell differentiation", "negative regulation of tenocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of tendon cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tendon cell differentiation. [GOC:obol]"}
{"concept_id": "C3270742", "aliases": ["positive regulation of muscle attachment cell differentiation", "positive regulation of tenocyte differentiation"], "types": ["T043"], "canonical_name": "positive regulation of tendon cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of tendon cell differentiation. [GOC:obol]"}
{"concept_id": "C3270743", "aliases": ["positive regulation of G1/S transition checkpoint"], "types": ["T038"], "canonical_name": "positive regulation of G1/S checkpoint"}
{"concept_id": "C3270744", "aliases": ["regulation of mesenchymal cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of mesenchymal cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3270745", "aliases": ["negative regulation of mesenchymal cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of mesenchymal cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3270746", "aliases": ["positive regulation of mesenchymal cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]"}
{"concept_id": "C3270747", "aliases": ["positive regulation of lysosomal cysteine-type endopeptidase", "positive regulation of thiol endopeptidase activity"], "types": ["T044"], "canonical_name": "positive regulation of cysteine-type endopeptidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity. [GOC:obol]"}
{"concept_id": "C3270748", "aliases": ["RNS metabolism", "RNS metabolic process", "reactive nitrogen species metabolism"], "types": ["T039"], "canonical_name": "reactive nitrogen species metabolic process", "definition": "The chemical reactions and pathways involving a reactive nitrogen species. [GOC:obol]"}
{"concept_id": "C3270749", "aliases": ["D-tagatose 6-phosphate metabolism"], "types": ["T044"], "canonical_name": "D-tagatose 6-phosphate metabolic process", "definition": "The chemical reactions and pathways involving a D-tagatose 6-phosphate. [GOC:obol]"}
{"concept_id": "C3270750", "aliases": ["D-tagatose 6-phosphate catabolism"], "types": ["T044"], "canonical_name": "D-tagatose 6-phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a D-tagatose 6-phosphate. [GOC:mengo_curators]"}
{"concept_id": "C3270751", "aliases": ["D-glycero-D-manno-heptose 7-phosphate metabolism"], "types": ["T044"], "canonical_name": "D-glycero-D-manno-heptose 7-phosphate metabolic process", "definition": "The chemical reactions and pathways involving a D-glycero-D-manno-heptose 7-phosphate. [GOC:mengo_curators]"}
{"concept_id": "C3270752", "aliases": ["D-glycero-D-manno-heptose 7-phosphate biosynthesis"], "types": ["T044"], "canonical_name": "D-glycero-D-manno-heptose 7-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a D-glycero-D-manno-heptose 7-phosphate. [GOC:mengo_curators]"}
{"concept_id": "C3270753", "aliases": [], "types": ["T044"], "canonical_name": "xylan binding", "definition": "Binding to xylan. [GOC:mengo_curators]"}
{"concept_id": "C3270754", "aliases": [], "types": ["T044"], "canonical_name": "glucomannan binding", "definition": "Binding to glucomannan. [GOC:mengo_curators]"}
{"concept_id": "C3270755", "aliases": [], "types": ["T044"], "canonical_name": "cellooligosaccharide binding", "definition": "Binding to cellooligosaccharide. [GOC:mengo_curators]"}
{"concept_id": "C3270756", "aliases": [], "types": ["T044"], "canonical_name": "mannan binding", "definition": "Binding to mannan. [GOC:mengo_curators]"}
{"concept_id": "C3270757", "aliases": [], "types": ["T044"], "canonical_name": "mannoglycan binding"}
{"concept_id": "C3270758", "aliases": [], "types": ["T044"], "canonical_name": "amylopectin binding", "definition": "Binding to amylopectin. [GOC:mengo_curators]"}
{"concept_id": "C3270759", "aliases": [], "types": ["T044"], "canonical_name": "pullulan binding", "definition": "Binding to pullulan. [GOC:mengo_curators]"}
{"concept_id": "C3270760", "aliases": [], "types": ["T044"], "canonical_name": "arabinoxylan binding", "definition": "Binding to arabinoxylan. [GOC:mengo_curators]"}
{"concept_id": "C3270761", "aliases": [], "types": ["T044"], "canonical_name": "glycogen binding", "definition": "Binding to glycogen. [GOC:mengo_curators]"}
{"concept_id": "C3270762", "aliases": [], "types": ["T044"], "canonical_name": "animal starch binding"}
{"concept_id": "C3270763", "aliases": [], "types": ["T044"], "canonical_name": "liver starch binding"}
{"concept_id": "C3270764", "aliases": [], "types": ["T044"], "canonical_name": "starch binding", "definition": "Binding to starch. [GOC:mengo_curators]"}
{"concept_id": "C3270765", "aliases": [], "types": ["T044"], "canonical_name": "amidon binding"}
{"concept_id": "C3270766", "aliases": [], "types": ["T044"], "canonical_name": "amylum binding"}
{"concept_id": "C3270767", "aliases": [], "types": ["T044"], "canonical_name": "maltoheptaose binding", "definition": "Binding to maltoheptaose. [GOC:mengo_curators]"}
{"concept_id": "C3270768", "aliases": [], "types": ["T044"], "canonical_name": "galactomannan binding", "definition": "Binding to galactomannan. [GOC:mengo_curators]"}
{"concept_id": "C3270769", "aliases": [], "types": ["T044"], "canonical_name": "cyclodextrin binding", "definition": "Binding to cyclodextrin. [GOC:mengo_curators]"}
{"concept_id": "C3270770", "aliases": [], "types": ["T038"], "canonical_name": "regulation of metanephric ureteric bud development", "definition": "Any process that modulates the frequency, rate or extent of metanephric ureteric bud development. [GOC:obol]"}
{"concept_id": "C3270771", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of metanephric ureteric bud development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric ureteric bud development. [GOC:obol]"}
{"concept_id": "C3270772", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of metanephric ureteric bud development", "definition": "Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development. [GOC:obol]"}
{"concept_id": "C3270773", "aliases": ["(1,3),(1,4)-beta-glucan binding", "beta-1,3-1,4-glucan binding", "beta-(1->3),(1->4)-glucan binding", "beta-(1,3),(1,4)-glucan binding", "beta-1->3,1->4-glucan binding", "1->3,1->4-beta-glucan binding"], "types": ["T044"], "canonical_name": "(1->3),(1->4)-beta-glucan binding", "definition": "Binding to (1->3),(1->4)-beta-glucan. [GOC:mengo_curators]"}
{"concept_id": "C3270774", "aliases": ["1,6-beta-D-glucan binding", "beta-1->6-D-glucan binding", "(1,6)-beta-D-glucan binding", "beta-(1,6)-D-glucan binding", "beta-1,6-D-glucan binding", "beta-(1->6)-D-glucan binding", "1->6-beta-D-glucan binding"], "types": ["T044"], "canonical_name": "(1->6)-beta-D-glucan binding", "definition": "Binding to (1->6)-beta-D-glucan. [GOC:mengo_curators]"}
{"concept_id": "C3270775", "aliases": [], "types": ["T044"], "canonical_name": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding", "definition": "Binding to beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc. [GOC:mengo_curators]"}
{"concept_id": "C3270776", "aliases": [], "types": ["T044"], "canonical_name": "chitosan binding", "definition": "Binding to chitosan. [GOC:mengo_curators]"}
{"concept_id": "C3270777", "aliases": ["(1,4)-beta-D-galactan binding"], "types": ["T044"], "canonical_name": "(1->4)-beta-D-galactan binding", "definition": "Binding to (1->4)-beta-D-galactan. [GOC:mengo_curators]"}
{"concept_id": "C3270778", "aliases": [], "types": ["T044"], "canonical_name": "inulin binding", "definition": "Binding to inulin. [GOC:mengo_curators]"}
{"concept_id": "C3270779", "aliases": [], "types": ["T044"], "canonical_name": "alpha-D-glucan binding", "definition": "Binding to alpha-D-glucan. [GOC:mengo_curators]"}
{"concept_id": "C3270780", "aliases": [], "types": ["T044"], "canonical_name": "L-arabinofuranose binding", "definition": "Binding to L-arabinofuranose. [GOC:mengo_curators]"}
{"concept_id": "C3270781", "aliases": [], "types": ["T044"], "canonical_name": "arabinogalactan binding", "definition": "Binding to arabinogalactan. [GOC:mengo_curators]"}
{"concept_id": "C3270783", "aliases": [], "types": ["T043"], "canonical_name": "sophorose transport", "definition": "The directed movement of a sophoroseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270784", "aliases": [], "types": ["T043"], "canonical_name": "trisaccharide transport", "definition": "The directed movement of a trisaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270785", "aliases": [], "types": ["T043"], "canonical_name": "maltotriose transport", "definition": "The directed movement of a maltotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270786", "aliases": [], "types": ["T043"], "canonical_name": "maltotriulose transport", "definition": "The directed movement of a maltotriuloseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270787", "aliases": [], "types": ["T043"], "canonical_name": "nigerotriose transport", "definition": "The directed movement of a nigerotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270788", "aliases": [], "types": ["T043"], "canonical_name": "arabinotriose transport", "definition": "The directed movement of an arabinotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270789", "aliases": [], "types": ["T043"], "canonical_name": "galactotriose transport", "definition": "The directed movement of a galactotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270790", "aliases": [], "types": ["T043"], "canonical_name": "xylotriose transport", "definition": "The directed movement of a xylotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270791", "aliases": [], "types": ["T043"], "canonical_name": "mannotriose transport", "definition": "The directed movement of a mannotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270792", "aliases": [], "types": ["T043"], "canonical_name": "cellotriose transport", "definition": "The directed movement of a cellotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270793", "aliases": [], "types": ["T043"], "canonical_name": "laminaritriose transport", "definition": "The directed movement of a laminaritrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270794", "aliases": [], "types": ["T043"], "canonical_name": "tetrasaccharide transport", "definition": "The directed movement of a tetrasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270795", "aliases": [], "types": ["T043"], "canonical_name": "maltotetraose transport", "definition": "The directed movement of a maltotetraoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270796", "aliases": [], "types": ["T043"], "canonical_name": "pentasaccharide transport", "definition": "The directed movement of a pentasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270797", "aliases": [], "types": ["T043"], "canonical_name": "maltopentaose transport", "definition": "The directed movement of a maltopentaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270798", "aliases": [], "types": ["T043"], "canonical_name": "hexasaccharide transport", "definition": "The directed movement of a hexasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270799", "aliases": [], "types": ["T043"], "canonical_name": "maltohexaose transport", "definition": "The directed movement of a maltohexaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270800", "aliases": [], "types": ["T043"], "canonical_name": "heptasaccharide transport", "definition": "The directed movement of a heptasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270801", "aliases": [], "types": ["T043"], "canonical_name": "maltoheptaose transport", "definition": "The directed movement of a maltoheptaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mengo_curators]"}
{"concept_id": "C3270802", "aliases": ["regulation of RhoGEF", "regulation of Rho guanine nucleotide exchange factor"], "types": ["T044"], "canonical_name": "regulation of Rho guanyl-nucleotide exchange factor activity", "definition": "Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. [GOC:obol]"}
{"concept_id": "C3270803", "aliases": ["negative regulation of RhoGEF", "negative regulation of Rho guanine nucleotide exchange factor"], "types": ["T044"], "canonical_name": "negative regulation of Rho guanyl-nucleotide exchange factor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. [GOC:obol]"}
{"concept_id": "C3270804", "aliases": ["positive regulation of RhoGEF", "positive regulation of Rho guanine nucleotide exchange factor"], "types": ["T044"], "canonical_name": "positive regulation of Rho guanyl-nucleotide exchange factor activity", "definition": "Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. [GOC:obol]"}
{"concept_id": "C3270805", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lens epithelial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of lens epithelial cell proliferation. [GOC:obol]"}
{"concept_id": "C3270806", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of lens epithelial cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lens epithelial cell proliferation. [GOC:obol]"}
{"concept_id": "C3270807", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of lens epithelial cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of lens epithelial cell proliferation. [GOC:obol]"}
{"concept_id": "C3270808", "aliases": ["regulation of cellular response to HGF stimulus"], "types": ["T043"], "canonical_name": "regulation of cellular response to hepatocyte growth factor stimulus", "definition": "Any process that modulates the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus. [GOC:obol]"}
{"concept_id": "C3270809", "aliases": ["negative regulation of cellular response to HGF stimulus"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to hepatocyte growth factor stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus. [GOC:obol]"}
{"concept_id": "C3270810", "aliases": ["positive regulation of cellular response to HGF stimulus"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to hepatocyte growth factor stimulus", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus. [GOC:obol]"}
{"concept_id": "C3270811", "aliases": ["methanopterin metabolism"], "types": ["T044"], "canonical_name": "methanopterin-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a methanopterin. [GOC:mengo_curators]"}
{"concept_id": "C3270812", "aliases": ["methanopterin biosynthesis"], "types": ["T044"], "canonical_name": "methanopterin-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a methanopterin. [GOC:mengo_curators]"}
{"concept_id": "C3270813", "aliases": ["tetrahydromethanopterin metabolism"], "types": ["T044"], "canonical_name": "tetrahydromethanopterin metabolic process", "definition": "The chemical reactions and pathways involving a tetrahydromethanopterin. [GOC:mengo_curators]"}
{"concept_id": "C3270814", "aliases": ["tetrahydromethanopterin biosynthesis"], "types": ["T044"], "canonical_name": "tetrahydromethanopterin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a tetrahydromethanopterin. [GOC:mengo_curators]"}
{"concept_id": "C3270815", "aliases": ["methanofuran metabolism"], "types": ["T044"], "canonical_name": "methanofuran metabolic process", "definition": "The chemical reactions and pathways involving a methanofuran. [GOC:mengo_curators]"}
{"concept_id": "C3270816", "aliases": ["methanofuran biosynthesis"], "types": ["T044"], "canonical_name": "methanofuran biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a methanofuran. [GOC:mengo_curators]"}
{"concept_id": "C3270817", "aliases": ["coenzyme gamma-F420-2 biosynthesis"], "types": ["T044"], "canonical_name": "coenzyme gamma-F420-2 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a coenzyme gamma-F420-2. [GOC:mengo_curators]"}
{"concept_id": "C3270818", "aliases": ["maltoheptaose metabolism"], "types": ["T044"], "canonical_name": "maltoheptaose metabolic process", "definition": "The chemical reactions and pathways involving a maltoheptaose. [GOC:mengo_curators]"}
{"concept_id": "C3270819", "aliases": ["maltoheptaose catabolism"], "types": ["T044"], "canonical_name": "maltoheptaose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a maltoheptaose. [GOC:mengo_curators]"}
{"concept_id": "C3270820", "aliases": [], "types": ["T038"], "canonical_name": "regulation of translational frameshifting", "definition": "Any process that modulates the frequency, rate or extent of translational frameshifting. [GOC:obol]"}
{"concept_id": "C3270821", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of translational frameshifting", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting. [GOC:obol]"}
{"concept_id": "C3270822", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of translational frameshifting", "definition": "Any process that activates or increases the frequency, rate or extent of translational frameshifting. [GOC:obol]"}
{"concept_id": "C3270823", "aliases": [], "types": ["T044"], "canonical_name": "methane biosynthetic process from formic acid", "definition": "The chemical reactions and pathways resulting in the formation of a methane from a formic acid. [GOC:mengo_curators]"}
{"concept_id": "C3270824", "aliases": [], "types": ["T044"], "canonical_name": "methane biosynthetic process from methylamine", "definition": "The chemical reactions and pathways resulting in the formation of a methane from a methylamine. [GOC:mengo_curators]"}
{"concept_id": "C3270825", "aliases": [], "types": ["T044"], "canonical_name": "methane biosynthetic process from dimethylamine", "definition": "The chemical reactions and pathways resulting in the formation of a methane from a dimethylamine. [GOC:mengo_curators]"}
{"concept_id": "C3270826", "aliases": [], "types": ["T044"], "canonical_name": "methane biosynthetic process from trimethylamine", "definition": "The chemical reactions and pathways resulting in the formation of a methane from a trimethylamine. [GOC:mengo_curators]"}
{"concept_id": "C3270827", "aliases": [], "types": ["T044"], "canonical_name": "methane biosynthetic process from dimethyl sulfide", "definition": "The chemical reactions and pathways resulting in the formation of a methane from a dimethyl sulfide. [GOC:mengo_curators]"}
{"concept_id": "C3270828", "aliases": [], "types": ["T044"], "canonical_name": "methane biosynthetic process from 3-(methylthio)propionic acid", "definition": "The chemical reactions and pathways resulting in the formation of a methane from a 3-(methylthio)propionic acid. [GOC:mengo_curators]"}
{"concept_id": "C3270829", "aliases": [], "types": ["T044"], "canonical_name": "methane biosynthetic process from methanethiol", "definition": "The chemical reactions and pathways resulting in the formation of a methane from a methanethiol. [GOC:mengo_curators]"}
{"concept_id": "C3270830", "aliases": [], "types": ["T044"], "canonical_name": "methane biosynthetic process from carbon monoxide", "definition": "The chemical reactions and pathways resulting in the formation of a methane from a carbon monoxide. [GOC:mengo_curators]"}
{"concept_id": "C3270831", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endocytic recycling", "definition": "Any process that modulates the frequency, rate or extent of endocytic recycling. [GOC:obol]"}
{"concept_id": "C3270832", "aliases": [], "types": ["T043"], "canonical_name": "regulation of retrograde transport of endocytic vesicles"}
{"concept_id": "C3270833", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endocytic recycling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling. [GOC:obol]"}
{"concept_id": "C3270834", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endocytic recycling", "definition": "Any process that activates or increases the frequency, rate or extent of endocytic recycling. [GOC:obol]"}
{"concept_id": "C3270835", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of retrograde transport of endocytic vesicles"}
{"concept_id": "C3270836", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phospholipid transport", "definition": "Any process that modulates the frequency, rate or extent of phospholipid transport. [GOC:obol]"}
{"concept_id": "C3270837", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phospholipid transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid transport. [GOC:obol]"}
{"concept_id": "C3270838", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phospholipid transport", "definition": "Any process that activates or increases the frequency, rate or extent of phospholipid transport. [GOC:obol]"}
{"concept_id": "C3270839", "aliases": ["regulation of RNA synthesis", "regulation of RNA biosynthesis", "regulation of RNA formation", "regulation of RNA anabolism"], "types": ["T044"], "canonical_name": "regulation of RNA biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of RNA biosynthetic process. [GOC:dph]"}
{"concept_id": "C3270840", "aliases": [], "types": ["T043"], "canonical_name": "nicotinate transport", "definition": "The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:obol]"}
{"concept_id": "C3270841", "aliases": [], "types": ["T043"], "canonical_name": "N-methylnicotinate transport", "definition": "The directed movement of a N-methylnicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:obol]"}
{"concept_id": "C3270842", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. [GOC:obol]"}
{"concept_id": "C3270843", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. [GOC:obol]"}
{"concept_id": "C3270844", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. [GOC:obol]"}
{"concept_id": "C3270845", "aliases": ["3-(1,3-thiazol-2-yl)-1H-indole binding"], "types": ["T044"], "canonical_name": "camalexin binding", "definition": "Binding to camalexin. [GOC:obol]"}
{"concept_id": "C3270846", "aliases": ["regulation of dipeptide membrane transport"], "types": ["T043"], "canonical_name": "regulation of dipeptide transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of dipeptide transmembrane transport. [GOC:obol]"}
{"concept_id": "C3270847", "aliases": ["negative regulation of dipeptide membrane transport"], "types": ["T043"], "canonical_name": "negative regulation of dipeptide transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transmembrane transport. [GOC:obol]"}
{"concept_id": "C3270848", "aliases": ["positive regulation of dipeptide membrane transport"], "types": ["T043"], "canonical_name": "positive regulation of dipeptide transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport. [GOC:obol]"}
{"concept_id": "C3270849", "aliases": [], "types": ["T038"], "canonical_name": "regulation of renal water transport", "definition": "Any process that modulates the frequency, rate or extent of renal water transport. [GOC:obol]"}
{"concept_id": "C3270850", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of renal water transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport. [GOC:obol]"}
{"concept_id": "C3270851", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of renal water transport", "definition": "Any process that activates or increases the frequency, rate or extent of renal water transport. [GOC:obol]"}
{"concept_id": "C3270852", "aliases": ["regulation of ethanol fermentation", "regulation of glucose fermentation to ethanol"], "types": ["T044"], "canonical_name": "regulation of glycolytic fermentation to ethanol", "definition": "Any process that modulates the frequency, rate or extent of glucose catabolic process to ethanol. [GOC:obol]"}
{"concept_id": "C3270853", "aliases": ["negative regulation of ethanol fermentation", "negative regulation of glucose fermentation to ethanol"], "types": ["T044"], "canonical_name": "negative regulation of glycolytic fermentation to ethanol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to ethanol. [GOC:obol]"}
{"concept_id": "C3270854", "aliases": ["regulation of proline degradation to glutamate", "regulation of proline breakdown to glutamate"], "types": ["T043"], "canonical_name": "regulation of proline catabolic process to glutamate", "definition": "Any process that modulates the frequency, rate or extent of proline catabolic process to glutamate. [GOC:obol]"}
{"concept_id": "C3270855", "aliases": [], "types": ["T040"], "canonical_name": "regulation of proline oxidation"}
{"concept_id": "C3270856", "aliases": ["negative regulation of proline degradation to glutamate", "negative regulation of proline breakdown to glutamate"], "types": ["T040"], "canonical_name": "negative regulation of proline catabolic process to glutamate", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of proline catabolic process to glutamate. [GOC:obol]"}
{"concept_id": "C3270857", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of proline oxidation"}
{"concept_id": "C3270858", "aliases": ["positive regulation of proline degradation to glutamate", "positive regulation of proline breakdown to glutamate"], "types": ["T044"], "canonical_name": "positive regulation of proline catabolic process to glutamate", "definition": "Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate. [GOC:obol]"}
{"concept_id": "C3270859", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of proline oxidation"}
{"concept_id": "C3270860", "aliases": ["regulation of cytoplasm to vacuole targeting", "regulation of cytoplasm-to-vacuole targeting"], "types": ["T043"], "canonical_name": "regulation of protein localization by the Cvt pathway", "definition": "Any process that modulates the frequency, rate or extent of protein localization by the Cvt pathway. [GOC:obol]"}
{"concept_id": "C3270861", "aliases": ["regulation of histone lysine H3 K79 methylation", "regulation of histone H3 K79 methylation", "regulation of histone H3K79me"], "types": ["T044"], "canonical_name": "regulation of histone H3-K79 methylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K79 methylation. [PMID:12876294]"}
{"concept_id": "C3270862", "aliases": ["negative regulation of histone H3K79me", "negative regulation of histone lysine H3 K79 methylation", "negative regulation of histone H3 K79 methylation"], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K79 methylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 methylation. [PMID:12876294]"}
{"concept_id": "C3270863", "aliases": ["positive regulation of histone H3K79me", "positive regulation of histone lysine H3 K79 methylation", "positive regulation of histone H3 K79 methylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K79 methylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K79 methylation. [PMID:12876294]"}
{"concept_id": "C3270864", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues", "definition": "Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. [PMID:15149594]"}
{"concept_id": "C3270865", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. [PMID:15149594]"}
{"concept_id": "C3270866", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues", "definition": "Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. [PMID:15149594]"}
{"concept_id": "C3270867", "aliases": [], "types": ["T045"], "canonical_name": "regulation of histone H2B ubiquitination", "definition": "Any process that modulates the frequency, rate or extent of histone H2B ubiquitination. [PMID:12876293]"}
{"concept_id": "C3270868", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of histone H2B ubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B ubiquitination. [PMID:12876293]"}
{"concept_id": "C3270869", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of histone H2B ubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination. [PMID:12876293]"}
{"concept_id": "C3270870", "aliases": ["regulation of ATP anabolism", "regulation of ATP synthesis", "regulation of ATP biosynthesis", "regulation of ATP formation"], "types": ["T044"], "canonical_name": "regulation of ATP biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of ATP biosynthetic process. [GOC:obol]"}
{"concept_id": "C3270871", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ATP regeneration"}
{"concept_id": "C3270872", "aliases": ["negative regulation of ATP biosynthesis", "negative regulation of ATP synthesis", "negative regulation of ATP anabolism", "negative regulation of ATP formation"], "types": ["T044"], "canonical_name": "negative regulation of ATP biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process. [GOC:obol]"}
{"concept_id": "C3270873", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ATP regeneration"}
{"concept_id": "C3270874", "aliases": ["positive regulation of ATP anabolism", "positive regulation of ATP biosynthesis", "positive regulation of ATP formation", "positive regulation of ATP synthesis"], "types": ["T044"], "canonical_name": "positive regulation of ATP biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process. [GOC:obol]"}
{"concept_id": "C3270875", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ATP regeneration"}
{"concept_id": "C3270876", "aliases": ["positive regulation of ethanol fermentation", "positive regulation of glucose fermentation to ethanol"], "types": ["T044"], "canonical_name": "positive regulation of glycolytic fermentation to ethanol", "definition": "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to ethanol. [GOC:obol]"}
{"concept_id": "C3270877", "aliases": [], "types": ["T045"], "canonical_name": "regulation of histone H2B conserved C-terminal lysine ubiquitination", "definition": "Any process that modulates the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination. [PMID:17576814]"}
{"concept_id": "C3270878", "aliases": [], "types": ["T045"], "canonical_name": "regulation of budding yeast H2B K123 ubiquitination"}
{"concept_id": "C3270879", "aliases": [], "types": ["T045"], "canonical_name": "regulation of fission yeast H2B K119 ubiquitination"}
{"concept_id": "C3270880", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mammalian H2B K120 ubiquitination"}
{"concept_id": "C3270881", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of histone H2B conserved C-terminal lysine ubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination. [PMID:17576814]"}
{"concept_id": "C3270882", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of budding yeast H2B K123 ubiquitination"}
{"concept_id": "C3270883", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of fission yeast H2B K119 ubiquitination"}
{"concept_id": "C3270884", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of mammalian H2B K120 ubiquitination"}
{"concept_id": "C3270885", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of histone H2B conserved C-terminal lysine ubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination. [PMID:17576814]"}
{"concept_id": "C3270886", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of budding yeast H2B K123 ubiquitination"}
{"concept_id": "C3270887", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of fission yeast H2B K119 ubiquitination"}
{"concept_id": "C3270888", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mammalian H2B K120 ubiquitination"}
{"concept_id": "C3270889", "aliases": [], "types": ["T040"], "canonical_name": "regulation of mediator complex assembly", "definition": "Any process that modulates the frequency, rate or extent of mediator complex assembly. [GOC:obol]"}
{"concept_id": "C3270890", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mediator complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mediator complex assembly. [GOC:obol]"}
{"concept_id": "C3270891", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mediator complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of mediator complex assembly. [GOC:obol]"}
{"concept_id": "C3270904", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CD8-positive, alpha-beta T cell activation", "definition": "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]"}
{"concept_id": "C3270905", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CD8-positive, alpha-beta T cell activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]"}
{"concept_id": "C3270906", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CD8-positive, alpha-beta T cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]"}
{"concept_id": "C3270907", "aliases": ["regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell"], "types": ["T043"], "canonical_name": "regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "definition": "Any process that modulates the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. [GOC:obol]"}
{"concept_id": "C3270908", "aliases": ["negative regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "negative regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "negative regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell"], "types": ["T038"], "canonical_name": "negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. [GOC:obol]"}
{"concept_id": "C3270909", "aliases": ["positive regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "positive regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "positive regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell"], "types": ["T043"], "canonical_name": "positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "definition": "Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. [GOC:obol]"}
{"concept_id": "C3270910", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gamma-delta T cell activation involved in immune response", "definition": "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response. [GOC:obol]"}
{"concept_id": "C3270911", "aliases": ["regulation of gamma-delta T-cell activation during immune response"], "types": ["T038"], "canonical_name": "regulation of gamma-delta T cell activation during immune response"}
{"concept_id": "C3270912", "aliases": ["regulation of gamma-delta T-lymphocyte activation during immune response"], "types": ["T038"], "canonical_name": "regulation of gamma-delta T lymphocyte activation during immune response"}
{"concept_id": "C3270913", "aliases": ["negative regulation of gamma-delta T cell activation during immune response", "negative regulation of gamma-delta T lymphocyte activation during immune response", "negative regulation of gamma-delta T-lymphocyte activation during immune response", "negative regulation of gamma-delta T-cell activation during immune response"], "types": ["T038"], "canonical_name": "negative regulation of gamma-delta T cell activation involved in immune response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response. [GOC:obol]"}
{"concept_id": "C3270914", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of gamma-delta T cell activation involved in immune response", "definition": "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response. [GOC:obol]"}
{"concept_id": "C3270915", "aliases": ["positive regulation of gamma-delta T-cell activation during immune response"], "types": ["T038"], "canonical_name": "positive regulation of gamma-delta T cell activation during immune response"}
{"concept_id": "C3270916", "aliases": ["positive regulation of gamma-delta T-lymphocyte activation during immune response"], "types": ["T038"], "canonical_name": "positive regulation of gamma-delta T lymphocyte activation during immune response"}
{"concept_id": "C3270917", "aliases": ["regulation of lysine biosynthesis via aminoadipic acid and saccharopine", "regulation of lysine biosynthetic process via aminoadipic acid and saccharopine"], "types": ["T044"], "canonical_name": "regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine", "definition": "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine. [GOC:obol]"}
{"concept_id": "C3270918", "aliases": ["negative regulation of lysine biosynthesis via aminoadipic acid and saccharopine", "negative regulation of lysine biosynthetic process via aminoadipic acid and saccharopine"], "types": ["T044"], "canonical_name": "negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine. [GOC:obol]"}
{"concept_id": "C3270919", "aliases": ["positive regulation of lysine biosynthesis via aminoadipic acid and saccharopine", "positive regulation of lysine biosynthetic process via aminoadipic acid and saccharopine"], "types": ["T044"], "canonical_name": "positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine", "definition": "Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine. [GOC:obol]"}
{"concept_id": "C3270920", "aliases": [], "types": ["T043"], "canonical_name": "basement membrane assembly involved in embryonic body morphogenesis", "definition": "Any basement membrane assembly that is involved in embryonic body morphogenesis. [GOC:obol]"}
{"concept_id": "C3270921", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendritic cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]"}
{"concept_id": "C3270922", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of dendritic cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]"}
{"concept_id": "C3270923", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of dendritic cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]"}
{"concept_id": "C3270927", "aliases": ["regulation of osteoclast cell development"], "types": ["T038"], "canonical_name": "regulation of osteoclast development", "definition": "Any process that modulates the frequency, rate or extent of osteoclast development. [GOC:obol]"}
{"concept_id": "C3270928", "aliases": ["negative regulation of osteoclast cell development"], "types": ["T043"], "canonical_name": "negative regulation of osteoclast development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. [GOC:obol]"}
{"concept_id": "C3270929", "aliases": ["positive regulation of osteoclast cell development"], "types": ["T043"], "canonical_name": "positive regulation of osteoclast development", "definition": "Any process that activates or increases the frequency, rate or extent of osteoclast development. [GOC:obol]"}
{"concept_id": "C3270930", "aliases": ["regulation of RNA elongation from Pol I promoter"], "types": ["T045"], "canonical_name": "regulation of transcription elongation from RNA polymerase I promoter", "definition": "Any process that modulates the frequency, rate or extent of transcription elongation from RNA polymerase I promoter. [PMID:20299458]"}
{"concept_id": "C3270931", "aliases": ["negative regulation of transcription elongation from RNA polymerase I promoter", "negative regulation of RNA elongation from Pol I promoter"], "types": ["T045"], "canonical_name": "negative regulation of transcription elongation by RNA polymerase I", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transcription elongation mediated by RNA polymerase I. [PMID:20299458]"}
{"concept_id": "C3270932", "aliases": ["positive regulation of RNA elongation from Pol I promoter"], "types": ["T045"], "canonical_name": "positive regulation of transcription elongation from RNA polymerase I promoter", "definition": "Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter. [PMID:20299458]"}
{"concept_id": "C3270933", "aliases": ["regulation of acetate-mevalonate pathway", "regulation of isopentenyl diphosphate anabolism, mevalonate pathway", "regulation of isopentenyl diphosphate formation, mevalonate pathway", "regulation of Ac-MVA pathway", "regulation of isopentenyl diphosphate synthesis, mevalonate pathway"], "types": ["T044"], "canonical_name": "regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway", "definition": "Any process that modulates the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. [GOC:al]"}
{"concept_id": "C3270934", "aliases": ["negative regulation of isopentenyl diphosphate anabolism, mevalonate pathway", "negative regulation of isopentenyl diphosphate formation, mevalonate pathway", "negative regulation of Ac-MVA pathway", "negative regulation of acetate-mevalonate pathway", "negative regulation of isopentenyl diphosphate synthesis, mevalonate pathway"], "types": ["T044"], "canonical_name": "negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. [GOC:al]"}
{"concept_id": "C3270935", "aliases": ["regulation of vascular morphogenesis"], "types": ["T043"], "canonical_name": "regulation of vasculogenesis", "definition": "Any process that modulates the frequency, rate or extent of vasculogenesis. [GOC:obol]"}
{"concept_id": "C3270936", "aliases": ["negative regulation of vascular morphogenesis"], "types": ["T043"], "canonical_name": "negative regulation of vasculogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. [GOC:obol]"}
{"concept_id": "C3270937", "aliases": ["positive regulation of vascular morphogenesis"], "types": ["T043"], "canonical_name": "positive regulation of vasculogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of vasculogenesis. [GOC:obol]"}
{"concept_id": "C3270949", "aliases": ["regulation of neuron chemotaxis", "regulation of neuronal migration"], "types": ["T043"], "canonical_name": "regulation of neuron migration", "definition": "Any process that modulates the frequency, rate or extent of neuron migration. [GOC:obol]"}
{"concept_id": "C3270950", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neuron guidance"}
{"concept_id": "C3270952", "aliases": ["negative regulation of neuron guidance", "negative regulation of neuron chemotaxis", "negative regulation of neuronal migration"], "types": ["T043"], "canonical_name": "negative regulation of neuron migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration. [GOC:obol]"}
{"concept_id": "C3270953", "aliases": ["positive regulation of neuron chemotaxis", "positive regulation of neuronal migration"], "types": ["T043"], "canonical_name": "positive regulation of neuron migration", "definition": "Any process that activates or increases the frequency, rate or extent of neuron migration. [GOC:obol]"}
{"concept_id": "C3270954", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of neuron guidance"}
{"concept_id": "C3270955", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chloride transport", "definition": "Any process that modulates the frequency, rate or extent of chloride transport. [GOC:dph]"}
{"concept_id": "C3270956", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of chloride transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport. [GOC:dph]"}
{"concept_id": "C3270957", "aliases": [], "types": ["T044"], "canonical_name": "quercitrin binding", "definition": "Binding to quercitrin. [GOC:obol]"}
{"concept_id": "C3270958", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to gamma radiation", "definition": "Any process that modulates the frequency, rate or extent of response to gamma radiation. [GOC:obol]"}
{"concept_id": "C3270959", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to gamma ray"}
{"concept_id": "C3270960", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to gamma-ray photon"}
{"concept_id": "C3270961", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of response to gamma radiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation. [GOC:obol]"}
{"concept_id": "C3270962", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of response to gamma ray"}
{"concept_id": "C3270963", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of response to gamma-ray photon"}
{"concept_id": "C3270964", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of response to gamma radiation", "definition": "Any process that activates or increases the frequency, rate or extent of response to gamma radiation. [GOC:obol]"}
{"concept_id": "C3270965", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of response to gamma ray"}
{"concept_id": "C3270966", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of response to gamma-ray photon"}
{"concept_id": "C3270967", "aliases": ["regulation of protein targeting to ascospore-type prospore membrane", "regulation of protein-prospore membrane targeting", "regulation of protein targeting to FSM"], "types": ["T038"], "canonical_name": "regulation of protein targeting to prospore membrane"}
{"concept_id": "C3270968", "aliases": [], "types": ["T038"], "canonical_name": "regulation of protein targeting to forespore membrane"}
{"concept_id": "C3270969", "aliases": ["positive regulation of protein targeting to FSM", "positive regulation of protein-prospore membrane targeting", "positive regulation of protein targeting to ascospore-type prospore membrane"], "types": ["T043"], "canonical_name": "positive regulation of protein targeting to prospore membrane"}
{"concept_id": "C3270970", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein targeting to forespore membrane"}
{"concept_id": "C3270971", "aliases": ["regulation of apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "regulation of apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270972", "aliases": ["negative regulation of apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270973", "aliases": ["positive regulation of apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270974", "aliases": ["regulation of extrinsic apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "regulation of extrinsic apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270975", "aliases": [], "types": ["T044"], "canonical_name": "regulation of extrinsic apoptosis"}
{"concept_id": "C3270976", "aliases": ["negative regulation of extrinsic apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of extrinsic apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270977", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of extrinsic apoptosis"}
{"concept_id": "C3270978", "aliases": ["positive regulation of extrinsic apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of extrinsic apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270979", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of extrinsic apoptosis"}
{"concept_id": "C3270980", "aliases": ["regulation of extrinsic apoptotic signalling pathway in absence of ligand"], "types": ["T044"], "canonical_name": "regulation of extrinsic apoptotic signaling pathway in absence of ligand", "definition": "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270981", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dependence receptor signaling pathway"}
{"concept_id": "C3270982", "aliases": [], "types": ["T044"], "canonical_name": "regulation of extrinsic apoptosis in absence of ligand"}
{"concept_id": "C3270983", "aliases": ["negative regulation of extrinsic apoptotic signalling pathway in absence of ligand"], "types": ["T044"], "canonical_name": "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270984", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of dependence receptor signaling pathway"}
{"concept_id": "C3270985", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of extrinsic apoptosis in absence of ligand"}
{"concept_id": "C3270986", "aliases": ["positive regulation of extrinsic apoptotic signalling pathway in absence of ligand"], "types": ["T044"], "canonical_name": "positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "definition": "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270987", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of dependence receptor signaling pathway"}
{"concept_id": "C3270988", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of extrinsic apoptosis in absence of ligand"}
{"concept_id": "C3270989", "aliases": ["regulation of intrinsic apoptotic signalling pathway", "regulation of mitochondrial-mediated apoptotic pathway", "regulation of intrinsic apoptotic pathway"], "types": ["T044"], "canonical_name": "regulation of intrinsic apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270990", "aliases": [], "types": ["T044"], "canonical_name": "regulation of intrinsic apoptosis"}
{"concept_id": "C3270991", "aliases": ["negative regulation of intrinsic apoptotic pathway", "negative regulation of mitochondrial-mediated apoptotic pathway", "negative regulation of intrinsic apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of intrinsic apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270992", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of intrinsic apoptosis"}
{"concept_id": "C3270993", "aliases": ["positive regulation of mitochondrial-mediated apoptotic pathway", "positive regulation of intrinsic apoptotic signalling pathway", "positive regulation of intrinsic apoptotic pathway"], "types": ["T044"], "canonical_name": "positive regulation of intrinsic apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3270994", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of intrinsic apoptosis"}
{"concept_id": "C3270995", "aliases": ["regulation of phosphatidylcholine anabolism", "regulation of phosphatidylcholine synthesis", "regulation of phosphatidylcholine formation", "regulation of phosphatidylcholine biosynthesis"], "types": ["T040"], "canonical_name": "regulation of phosphatidylcholine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process. [GOC:obol]"}
{"concept_id": "C3270996", "aliases": ["negative regulation of phosphatidylcholine synthesis", "negative regulation of phosphatidylcholine formation", "negative regulation of phosphatidylcholine biosynthesis", "negative regulation of phosphatidylcholine anabolism"], "types": ["T040"], "canonical_name": "negative regulation of phosphatidylcholine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process. [GOC:obol]"}
{"concept_id": "C3270997", "aliases": ["positive regulation of phosphatidylcholine synthesis", "positive regulation of phosphatidylcholine anabolism", "positive regulation of phosphatidylcholine biosynthesis", "positive regulation of phosphatidylcholine formation"], "types": ["T044"], "canonical_name": "positive regulation of phosphatidylcholine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process. [GOC:obol]"}
{"concept_id": "C3270998", "aliases": ["regulation of glutamate metabolic process via glutamine and ammonia", "regulation of glutamate metabolism via glutamine and ammonia"], "types": ["T044"], "canonical_name": "regulation of ammonia assimilation cycle", "definition": "Any process that modulates the frequency, rate or extent of ammonia assimilation cycle. [GOC:BHF]"}
{"concept_id": "C3270999", "aliases": ["negative regulation of glutamate metabolic process via glutamine and ammonia", "negative regulation of glutamate metabolism via glutamine and ammonia"], "types": ["T043"], "canonical_name": "negative regulation of ammonia assimilation cycle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle. [GOC:BHF]"}
{"concept_id": "C3271000", "aliases": ["positive regulation of glutamate metabolism via glutamine and ammonia", "positive regulation of glutamate metabolic process via glutamine and ammonia"], "types": ["T043"], "canonical_name": "positive regulation of ammonia assimilation cycle", "definition": "Any process that activates or increases the frequency, rate or extent of ammonia assimilation cycle. [GOC:BHF]"}
{"concept_id": "C3271001", "aliases": ["negative regulation of chromosome organisation"], "types": ["T043"], "canonical_name": "negative regulation of chromosome organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. [GOC:obol]"}
{"concept_id": "C3271002", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of chromosome organization and biogenesis"}
{"concept_id": "C3271003", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of maintenance of genome integrity"}
{"concept_id": "C3271004", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of nuclear genome maintenance"}
{"concept_id": "C3271005", "aliases": ["positive regulation of chromosome organisation"], "types": ["T043"], "canonical_name": "positive regulation of chromosome organization", "definition": "Any process that activates or increases the frequency, rate or extent of chromosome organization. [GOC:obol]"}
{"concept_id": "C3271006", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of chromosome organization and biogenesis"}
{"concept_id": "C3271007", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of maintenance of genome integrity"}
{"concept_id": "C3271008", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of nuclear genome maintenance"}
{"concept_id": "C3271009", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H3-K36 trimethylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K36 trimethylation. [PMID:17948059]"}
{"concept_id": "C3271010", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K36 trimethylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K36 trimethylation. [PMID:17948059]"}
{"concept_id": "C3271011", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K36 trimethylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K36 trimethylation. [PMID:17948059]"}
{"concept_id": "C3271012", "aliases": ["regulation of SOCE", "regulation of capacitative calcium entry", "regulation of store-operated calcium import"], "types": ["T038"], "canonical_name": "regulation of store-operated calcium entry", "definition": "Any process that modulates the frequency, rate or extent of store-operated calcium entry. [GOC:BHF]"}
{"concept_id": "C3271013", "aliases": ["regulation of nonselective cation channel activity", "regulation of cation diffusion facilitator activity"], "types": ["T038"], "canonical_name": "regulation of cation channel activity", "definition": "Any process that modulates the frequency, rate or extent of cation channel activity. [GOC:BHF]"}
{"concept_id": "C3271014", "aliases": ["negative regulation of cation diffusion facilitator activity", "negative regulation of nonselective cation channel activity"], "types": ["T038"], "canonical_name": "negative regulation of cation channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. [GOC:BHF]"}
{"concept_id": "C3271015", "aliases": ["positive regulation of cation diffusion facilitator activity", "positive regulation of nonselective cation channel activity"], "types": ["T038"], "canonical_name": "positive regulation of cation channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of cation channel activity. [GOC:BHF]"}
{"concept_id": "C3271016", "aliases": ["regulation of semaphorin-plexin signalling pathway"], "types": ["T044"], "canonical_name": "regulation of semaphorin-plexin signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway. [GOC:BHF]"}
{"concept_id": "C3271017", "aliases": ["negative regulation of semaphorin-plexin signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of semaphorin-plexin signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway. [GOC:BHF]"}
{"concept_id": "C3271018", "aliases": ["positive regulation of semaphorin-plexin signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of semaphorin-plexin signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway. [GOC:BHF]"}
{"concept_id": "C3271019", "aliases": [], "types": ["T044"], "canonical_name": "regulation of C-C chemokine binding", "definition": "Any process that modulates the frequency, rate or extent of C-C chemokine binding. [GOC:obol]"}
{"concept_id": "C3271020", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of C-C chemokine binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding. [GOC:obol]"}
{"concept_id": "C3271021", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of C-C chemokine binding", "definition": "Any process that activates or increases the frequency, rate or extent of C-C chemokine binding. [GOC:obol]"}
{"concept_id": "C3271022", "aliases": ["ROBO/SLIT signaling pathway involved in axon pathfinding", "ROBO signaling pathway involved in axon guidance", "Roundabout signaling pathway involved in axon pathfinding", "Roundabout signalling pathway involved in axon pathfinding", "ROBO/SLIT signaling pathway involved in axon guidance", "Roundabout signalling pathway involved in axon guidance", "ROBO signaling pathway involved in axon pathfinding"], "types": ["T044"], "canonical_name": "Roundabout signaling pathway involved in axon guidance", "definition": "Any Roundabout signaling pathway that is involved in axon guidance. [GOC:bf, PMID:14527427, PMID:21820427]"}
{"concept_id": "C3271023", "aliases": [], "types": ["T044"], "canonical_name": "ROBO signaling pathway involved in axon chemotaxis"}
{"concept_id": "C3271024", "aliases": [], "types": ["T044"], "canonical_name": "ROBO signaling pathway involved in axon growth cone guidance"}
{"concept_id": "C3271025", "aliases": [], "types": ["T044"], "canonical_name": "ROBO/SLIT signaling pathway involved in axon chemotaxis"}
{"concept_id": "C3271026", "aliases": [], "types": ["T044"], "canonical_name": "ROBO/SLIT signaling pathway involved in axon growth cone guidance"}
{"concept_id": "C3271027", "aliases": ["Roundabout signalling pathway involved in axon chemotaxis"], "types": ["T044"], "canonical_name": "Roundabout signaling pathway involved in axon chemotaxis"}
{"concept_id": "C3271028", "aliases": ["Roundabout signalling pathway involved in axon growth cone guidance"], "types": ["T044"], "canonical_name": "Roundabout signaling pathway involved in axon growth cone guidance"}
{"concept_id": "C3271029", "aliases": ["regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3271030", "aliases": [], "types": ["T044"], "canonical_name": "regulation of initiator caspase activity"}
{"concept_id": "C3271031", "aliases": ["negative regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3271032", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of initiator caspase activity"}
{"concept_id": "C3271033", "aliases": ["positive regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3271034", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of initiator caspase activity"}
{"concept_id": "C3271035", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis", "definition": "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. [GOC:mtg_apoptosis]"}
{"concept_id": "C3271036", "aliases": [], "types": ["T044"], "canonical_name": "regulation of effector caspase activity"}
{"concept_id": "C3271037", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. [GOC:mtg_apoptosis]"}
{"concept_id": "C3271038", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of effector caspase activity"}
{"concept_id": "C3271039", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis", "definition": "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. [GOC:mtg_apoptosis]"}
{"concept_id": "C3271040", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of effector caspase activity"}
{"concept_id": "C3271044", "aliases": ["regulation of leucine anabolism", "regulation of leucine biosynthesis", "regulation of leucine formation", "regulation of leucine synthesis"], "types": ["T044"], "canonical_name": "regulation of leucine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of leucine biosynthetic process. [GOC:obol]"}
{"concept_id": "C3271045", "aliases": ["negative regulation of leucine biosynthesis", "negative regulation of leucine anabolism", "negative regulation of leucine synthesis", "negative regulation of leucine formation"], "types": ["T044"], "canonical_name": "negative regulation of leucine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leucine biosynthetic process. [GOC:obol]"}
{"concept_id": "C3271046", "aliases": ["positive regulation of leucine formation", "positive regulation of leucine synthesis", "positive regulation of leucine anabolism", "positive regulation of leucine biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of leucine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of leucine biosynthetic process. [GOC:obol]"}
{"concept_id": "C3271047", "aliases": ["regulation of unsaturated fatty acid formation", "regulation of unsaturated fatty acid anabolism", "regulation of unsaturated fatty acid biosynthesis", "regulation of unsaturated fatty acid synthesis"], "types": ["T043"], "canonical_name": "regulation of unsaturated fatty acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process. [GO:0006636]"}
{"concept_id": "C3271048", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fatty acid desaturation"}
{"concept_id": "C3271049", "aliases": [], "types": ["T043"], "canonical_name": "regulation of polyunsaturated fatty acid biosynthesis"}
{"concept_id": "C3271050", "aliases": ["positive regulation of unsaturated fatty acid anabolism", "positive regulation of unsaturated fatty acid formation", "positive regulation of unsaturated fatty acid synthesis", "positive regulation of unsaturated fatty acid biosynthesis"], "types": ["T043"], "canonical_name": "positive regulation of unsaturated fatty acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process. [GO:0006636]"}
{"concept_id": "C3271051", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of fatty acid desaturation"}
{"concept_id": "C3271052", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of polyunsaturated fatty acid biosynthesis"}
{"concept_id": "C3271053", "aliases": ["regulation of muscle cell chemotaxis towards tendon cell"], "types": ["T043"], "canonical_name": "regulation of muscle cell chemotaxis toward tendon cell", "definition": "Any process that modulates the frequency, rate or extent of muscle cell chemotaxis toward tendon cell. [GOC:sart]"}
{"concept_id": "C3271054", "aliases": [], "types": ["T043"], "canonical_name": "regulation of muscle cell attraction"}
{"concept_id": "C3271055", "aliases": ["negative regulation of muscle cell chemotaxis towards tendon cell"], "types": ["T043"], "canonical_name": "negative regulation of muscle cell chemotaxis toward tendon cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. For example, when the muscle cell arrives at the target tendon cell, migration is arrested so that attachments can be made between the cells. [GOC:sart, PMID:19793885, PMID:20404543]"}
{"concept_id": "C3271056", "aliases": [], "types": ["T043"], "canonical_name": "arrest of muscle cell chemotaxis"}
{"concept_id": "C3271057", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of muscle cell attraction"}
{"concept_id": "C3271058", "aliases": ["ROBO/SLIT signaling pathway involved in muscle cell chemotaxis toward tendon cell", "Roundabout signalling pathway involved in muscle cell chemotaxis toward tendon cell", "ROBO signaling pathway involved in muscle cell chemotaxis towards tendon cell", "ROBO signaling pathway involved in muscle cell chemotaxis toward tendon cell", "ROBO/SLIT signaling pathway involved in muscle cell chemotaxis towards tendon cell", "Roundabout signaling pathway involved in muscle cell chemotaxis towards tendon cell", "Roundabout signalling pathway involved in muscle cell chemotaxis towards tendon cell"], "types": ["T044"], "canonical_name": "Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell", "definition": "Any Roundabout signaling pathway that is involved in the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. [GOC:bf, GOC:obol, GOC:sart, PMID:19793885]"}
{"concept_id": "C3271059", "aliases": [], "types": ["T044"], "canonical_name": "ROBO signaling pathway involved in muscle cell attraction"}
{"concept_id": "C3271060", "aliases": [], "types": ["T044"], "canonical_name": "ROBO/SLIT signaling pathway involved in muscle cell attraction"}
{"concept_id": "C3271061", "aliases": ["Roundabout signalling pathway involved in muscle cell attraction"], "types": ["T044"], "canonical_name": "Roundabout signaling pathway involved in muscle cell attraction"}
{"concept_id": "C3271062", "aliases": ["regulation of bone morphogenetic protein secretion", "regulation of BMP protein secretion"], "types": ["T043"], "canonical_name": "regulation of BMP secretion", "definition": "Any process that modulates the frequency, rate or extent of BMP secretion. [GOC:sart]"}
{"concept_id": "C3271063", "aliases": ["negative regulation of BMP protein secretion", "negative regulation of bone morphogenetic protein secretion"], "types": ["T043"], "canonical_name": "negative regulation of BMP secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of BMP secretion. [GOC:sart]"}
{"concept_id": "C3271064", "aliases": ["regulation of caveolae-mediated endocytosis", "regulation of caveolae-dependent endocytosis", "regulation of caveolin-dependent endocytosis"], "types": ["T043"], "canonical_name": "regulation of caveolin-mediated endocytosis", "definition": "Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis. [GOC:obol]"}
{"concept_id": "C3271065", "aliases": ["negative regulation of caveolae-dependent endocytosis", "negative regulation of caveolin-dependent endocytosis", "negative regulation of caveolae-mediated endocytosis"], "types": ["T043"], "canonical_name": "negative regulation of caveolin-mediated endocytosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis. [GOC:obol]"}
{"concept_id": "C3271066", "aliases": ["positive regulation of caveolin-dependent endocytosis", "positive regulation of caveolae-mediated endocytosis", "positive regulation of caveolae-dependent endocytosis"], "types": ["T043"], "canonical_name": "positive regulation of caveolin-mediated endocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis. [GOC:obol]"}
{"concept_id": "C3271067", "aliases": ["2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolism", "2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolic process", "lipid X metabolism"], "types": ["T044"], "canonical_name": "lipid X metabolic process", "definition": "The chemical reactions and pathways involving lipid X, 2,3-diacylglucosamine 1-phosphate. [GOC:obol]"}
{"concept_id": "C3271068", "aliases": [], "types": ["T044"], "canonical_name": "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolic process"}
{"concept_id": "C3271069", "aliases": [], "types": ["T044"], "canonical_name": "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolism"}
{"concept_id": "C3271070", "aliases": [], "types": ["T044"], "canonical_name": "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolic process"}
{"concept_id": "C3271071", "aliases": [], "types": ["T044"], "canonical_name": "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolism"}
{"concept_id": "C3271072", "aliases": ["hydroperoxide metabolism"], "types": ["T044"], "canonical_name": "hydroperoxide metabolic process", "definition": "The chemical reactions and pathways involving a hydroperoxide. [GOC:rs, PMID:15917183, PMID:18084891]"}
{"concept_id": "C3271073", "aliases": ["codeine metabolism"], "types": ["T044"], "canonical_name": "codeine metabolic process", "definition": "The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties. [GOC:yaf]"}
{"concept_id": "C3271074", "aliases": ["codeine breakdown", "codeine catabolism", "codeine degradation"], "types": ["T044"], "canonical_name": "codeine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties. [GOC:yaf, UniPathway:UPA00318]"}
{"concept_id": "C3271075", "aliases": ["malonyl-CoA metabolism"], "types": ["T044"], "canonical_name": "malonyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving malonyl-CoA, the S-malonyl derivative of coenzyme A. [GOC:yaf, PMID:11902724, PMID:15726818, PMID:18981598]"}
{"concept_id": "C3271076", "aliases": ["malonyl-CoA degradation", "malonyl-CoA breakdown", "malonyl-CoA catabolism"], "types": ["T044"], "canonical_name": "malonyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A. [GOC:yaf]"}
{"concept_id": "C3271077", "aliases": ["malonyl-CoA biosynthesis", "malonyl-CoA formation", "malonyl-CoA synthesis", "malonyl-CoA anabolism"], "types": ["T044"], "canonical_name": "malonyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A. [GOC:yaf, UniPathway:UPA00655]"}
{"concept_id": "C3271078", "aliases": ["N(omega)-methyl-L-arginine metabolism"], "types": ["T044"], "canonical_name": "N(omega)-methyl-L-arginine metabolic process", "definition": "The chemical reactions and pathways involving N(omega)-methyl-L-arginine. [GOC:rs, PMID:10510241]"}
{"concept_id": "C3271079", "aliases": ["N(omega)-methyl-L-arginine breakdown", "N(omega)-methyl-L-arginine catabolism", "N(omega)-methyl-L-arginine degradation"], "types": ["T044"], "canonical_name": "N(omega)-methyl-L-arginine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine. [GOC:rs, PMID:10510241]"}
{"concept_id": "C3271080", "aliases": ["N(omega),N(omega)-dimethyl-L-arginine metabolism"], "types": ["T044"], "canonical_name": "N(omega),N(omega)-dimethyl-L-arginine metabolic process", "definition": "The chemical reactions and pathways involving N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group. [GOC:rs, PMID:10510241]"}
{"concept_id": "C3271081", "aliases": ["N(omega),N(omega)-dimethyl-L-arginine breakdown", "N(omega),N(omega)-dimethyl-L-arginine degradation", "N(omega),N(omega)-dimethyl-L-arginine catabolism"], "types": ["T044"], "canonical_name": "N(omega),N(omega)-dimethyl-L-arginine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group. [GOC:rs, PMID:10510241]"}
{"concept_id": "C3271082", "aliases": ["lipoxin metabolism"], "types": ["T044"], "canonical_name": "lipoxin metabolic process", "definition": "The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid. [GOC:mw]"}
{"concept_id": "C3271083", "aliases": ["lipoxin formation", "lipoxin synthesis", "lipoxin anabolism", "lipoxin biosynthesis"], "types": ["T044"], "canonical_name": "lipoxin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid. [GOC:mw]"}
{"concept_id": "C3271084", "aliases": ["lipoxin A4 metabolism", "LXA4 metabolic process", "LXA4 metabolism"], "types": ["T044"], "canonical_name": "lipoxin A4 metabolic process", "definition": "The chemical reactions and pathways involving lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds. [GOC:mw]"}
{"concept_id": "C3271085", "aliases": ["lipoxin A4 synthesis", "LXA4 synthesis", "lipoxin A4 anabolism", "LXA4 biosynthetic process", "lipoxin A4 formation", "LXA4 anabolism", "LXA4 formation", "LXA4 biosynthesis", "lipoxin A4 biosynthesis"], "types": ["T044"], "canonical_name": "lipoxin A4 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds. [GOC:mw]"}
{"concept_id": "C3271086", "aliases": ["LXB4 metabolic process", "lipoxin B4 metabolism", "LXB4 metabolism"], "types": ["T044"], "canonical_name": "lipoxin B4 metabolic process", "definition": "The chemical reactions and pathways involving lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds. [GOC:mw]"}
{"concept_id": "C3271087", "aliases": ["xanthones metabolic process", "xanthones metabolism", "xanthone metabolism", "xanthone-containing compound metabolism"], "types": ["T044"], "canonical_name": "xanthone-containing compound metabolic process", "definition": "The chemical reactions and pathways involving a xanthone-containing compound. [GOC:di]"}
{"concept_id": "C3271089", "aliases": ["lipoxin B4 formation", "LXB4 formation", "lipoxin B4 anabolism", "LXB4 synthesis", "lipoxin B4 biosynthesis", "LXB4 anabolism", "lipoxin B4 synthesis", "LXB4 biosynthesis", "LXB4 biosynthetic process"], "types": ["T044"], "canonical_name": "lipoxin B4 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds. [GOC:mw]"}
{"concept_id": "C3271090", "aliases": ["xanthones biosynthetic process", "xanthone biosynthetic process", "xanthone-containing compound biosynthesis", "xanthones biosynthesis", "xanthones anabolism", "xanthone-containing compound anabolism", "xanthone-containing compound synthesis", "xanthone biosynthesis", "xanthones formation", "xanthone-containing compound formation", "xanthones synthesis"], "types": ["T044"], "canonical_name": "xanthone-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a xanthone-containing compound. [GOC:di]"}
{"concept_id": "C3271092", "aliases": ["gliotoxin metabolism"], "types": ["T044"], "canonical_name": "gliotoxin metabolic process", "definition": "The chemical reactions and pathways involving the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. [PMID:16333108, PMID:17574915, PMID:18272357]"}
{"concept_id": "C3271093", "aliases": ["gliotoxin degradation", "gliotoxin breakdown", "gliotoxin catabolism"], "types": ["T044"], "canonical_name": "gliotoxin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357]"}
{"concept_id": "C3271094", "aliases": ["gliotoxin anabolism", "gliotoxin synthesis", "gliotoxin formation", "gliotoxin biosynthesis"], "types": ["T044"], "canonical_name": "gliotoxin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357, PMID:29966253]"}
{"concept_id": "C3271095", "aliases": ["bis(monoacylglycerol) hydrogen phosphate (BMP) metabolic process", "bis(monoacylglycerol) hydrogen phosphate (BMP) metabolism", "bis(monoacylglycerol) hydrogen phosphate metabolic process", "lysobisphosphatidic acid metabolism", "bis(monoacylglycerol) hydrogen phosphate metabolism", "LBPA metabolism", "LBPA metabolic process"], "types": ["T044"], "canonical_name": "lysobisphosphatidic acid metabolic process", "definition": "The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group. [GOC:mw]"}
{"concept_id": "C3271096", "aliases": ["bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthetic process", "LBPA biosynthetic process", "LBPA formation", "bis(monoacylglycerol) hydrogen phosphate (BMP) anabolism", "LBPA biosynthesis", "lysobisphosphatidic acid formation", "LBPA anabolism", "LBPA synthesis", "bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthesis", "bis(monoacylglycerol) hydrogen phosphate biosynthesis", "lysobisphosphatidic acid anabolism", "bis(monoacylglycerol) hydrogen phosphate formation", "bis(monoacylglycerol) hydrogen phosphate anabolism", "bis(monoacylglycerol) hydrogen phosphate biosynthetic process", "lysobisphosphatidic acid synthesis", "bis(monoacylglycerol) hydrogen phosphate (BMP) synthesis", "bis(monoacylglycerol) hydrogen phosphate synthesis", "bis(monoacylglycerol) hydrogen phosphate (BMP) formation", "lysobisphosphatidic acid biosynthesis"], "types": ["T044"], "canonical_name": "lysobisphosphatidic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group. [GOC:mw]"}
{"concept_id": "C3271097", "aliases": ["UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolism"], "types": ["T044"], "canonical_name": "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process", "definition": "The chemical reactions and pathways involving a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. [GOC:yaf]"}
{"concept_id": "C3271098", "aliases": ["UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolism", "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose degradation", "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose breakdown"], "types": ["T044"], "canonical_name": "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. [GOC:yaf]"}
{"concept_id": "C3271099", "aliases": ["UDP-4-deoxy-4-formamido-beta-L-arabinopyranose formation", "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthesis", "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose anabolism", "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose synthesis"], "types": ["T044"], "canonical_name": "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. [GOC:yaf, UniPathway:UPA00032]"}
{"concept_id": "C3271101", "aliases": [], "types": ["T044"], "canonical_name": "17beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C3271102", "aliases": [], "types": ["T044"], "canonical_name": "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"}
{"concept_id": "C3271103", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"}
{"concept_id": "C3271104", "aliases": [], "types": ["T044"], "canonical_name": "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity"}
{"concept_id": "C3271105", "aliases": [], "types": ["T044"], "canonical_name": "ionotropic receptor activity"}
{"concept_id": "C3271108", "aliases": [], "types": ["T043"], "canonical_name": "nucleobase-containing compound transport", "definition": "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C3271109", "aliases": [], "types": ["T044"], "canonical_name": "nucleobase-containing compound transmembrane transporter activity", "definition": "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. [GOC:ai]"}
{"concept_id": "C3271110", "aliases": [], "types": ["T045"], "canonical_name": "nucleobase-containing small molecule interconversion", "definition": "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. [GOC:mah, ISBN:0306444747, ISBN:0471394831]"}
{"concept_id": "C3271113", "aliases": [], "types": ["T043"], "canonical_name": "nuclear-encoded tRNA import into mitochondrion"}
{"concept_id": "C3271114", "aliases": [], "types": ["T044"], "canonical_name": "long-chain fatty-acyl-CoA hydrolase activity"}
{"concept_id": "C3271117", "aliases": [], "types": ["T044"], "canonical_name": "protein maturation by proteolysis"}
{"concept_id": "C3271118", "aliases": ["mitochondrial fatty acid beta-oxidation multienzyme complex location"], "types": ["T026"], "canonical_name": "mitochondrial fatty acid beta-oxidation multienzyme complex", "definition": "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. [GOC:ma]"}
{"concept_id": "C3271120", "aliases": [], "types": ["T044"], "canonical_name": "galactoside 3(4)-L-fucosyltransferase activity"}
{"concept_id": "C3271122", "aliases": ["glucosidase II complex location"], "types": ["T026"], "canonical_name": "glucosidase II complex", "definition": "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins. [PMID:10464333, PMID:8910335]"}
{"concept_id": "C3271128", "aliases": [], "types": ["T044"], "canonical_name": "nucleobase-containing compound kinase activity", "definition": "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. [GOC:jl]"}
{"concept_id": "C3271129", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}
{"concept_id": "C3271132", "aliases": ["L-threonine catabolic process to methylglyoxal", "L-threonine breakdown to D-lactate", "L-threonine catabolism to D-lactate", "L-threonine degradation to D-lactate"], "types": ["T044"], "canonical_name": "L-threonine catabolic process to D-lactate", "definition": "The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate. [GOC:bf, GOC:jl, MetaCyc:PWY-901, MetaCyc:THRDLCTCAT-PWY]"}
{"concept_id": "C3271133", "aliases": [], "types": ["T044"], "canonical_name": "L-threonine catabolic process to (R)-lactate"}
{"concept_id": "C3271134", "aliases": ["L-threonine catabolic process to pyruvate"], "types": ["T044"], "canonical_name": "L-threonine catabolic process to pyruvate"}
{"concept_id": "C3271135", "aliases": ["L-threonine degradation to glycine", "L-threonine catabolism to glycine", "L-threonine breakdown to glycine"], "types": ["T044"], "canonical_name": "L-threonine catabolic process to glycine", "definition": "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine. [GOC:bf, GOC:mah, MetaCyc:THREONINE-DEG2-PWY]"}
{"concept_id": "C3271136", "aliases": [], "types": ["T044"], "canonical_name": "catechol-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. [GOC:go_curators]"}
{"concept_id": "C3271137", "aliases": [], "types": ["T044"], "canonical_name": "syntaxin-13 binding"}
{"concept_id": "C3271138", "aliases": [], "types": ["T044"], "canonical_name": "syntaxin-2 binding"}
{"concept_id": "C3271139", "aliases": [], "types": ["T042"], "canonical_name": "inferior central nucleus development"}
{"concept_id": "C3271140", "aliases": [], "types": ["T042"], "canonical_name": "posterior raphe nucleus development"}
{"concept_id": "C3271141", "aliases": [], "types": ["T042"], "canonical_name": "anterior raphe nucleus development"}
{"concept_id": "C3271142", "aliases": [], "types": ["T042"], "canonical_name": "superior central nucleus development"}
{"concept_id": "C3271143", "aliases": ["forebrain anterior-posterior pattern specification"], "types": ["T042"], "canonical_name": "forebrain anterior/posterior pattern specification", "definition": "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C3271144", "aliases": [], "types": ["T042"], "canonical_name": "chaeta development", "definition": "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell. [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]"}
{"concept_id": "C3271145", "aliases": [], "types": ["T042"], "canonical_name": "multicellular organism dormancy process"}
{"concept_id": "C3271146", "aliases": [], "types": ["T044"], "canonical_name": "ionotropic neurotransmitter receptor activity"}
{"concept_id": "C3271154", "aliases": [], "types": ["T026"], "definition": "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. [GOC:mah, ISBN:0198506732]", "canonical_name": "secretory granule"}
{"concept_id": "C3271157", "aliases": [], "types": ["T044"], "canonical_name": "intracellular steroid hormone receptor signaling pathway", "definition": "The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. [GOC:mah, GOC:signaling]"}
{"concept_id": "C3271158", "aliases": [], "types": ["T044"], "canonical_name": "intracellular estrogen receptor signaling pathway", "definition": "The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]"}
{"concept_id": "C3271160", "aliases": ["IFT complex location"], "types": ["T026"], "canonical_name": "IFT complex"}
{"concept_id": "C3271162", "aliases": ["IFT complex A", "IFT complex A location", "IFT A complex location"], "types": ["T026"], "canonical_name": "IFT A complex"}
{"concept_id": "C3271166", "aliases": [], "types": ["T044"], "canonical_name": "ABP-278/276 binding"}
{"concept_id": "C3271167", "aliases": [], "types": ["T044"], "canonical_name": "ABPL binding"}
{"concept_id": "C3271168", "aliases": [], "types": ["T044"], "canonical_name": "filamin-2 binding"}
{"concept_id": "C3271169", "aliases": [], "types": ["T044"], "canonical_name": "filamin-3 binding"}
{"concept_id": "C3271170", "aliases": ["filamin-A binding"], "types": ["T044"], "canonical_name": "filamin A binding"}
{"concept_id": "C3271171", "aliases": [], "types": ["T044"], "canonical_name": "gamma-filamin binding"}
{"concept_id": "C3271172", "aliases": ["alpha-1,2-fucosyltransferase activity", "alpha-(1->2)-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "alpha-(1,2)-fucosyltransferase activity", "definition": "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage. [GOC:mah]"}
{"concept_id": "C3271176", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding"}
{"concept_id": "C3271178", "aliases": ["DNA-dependent transcriptional start site selection"], "types": ["T045"], "canonical_name": "DNA-templated transcriptional start site selection", "definition": "Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. [GOC:txnOH, PMID:16826228, PMID:18846104]"}
{"concept_id": "C3271179", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional start site selection at RNA polymerase II promoter", "definition": "Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. [GOC:txnOH, PMID:16826228, PMID:18846104]"}
{"concept_id": "C3271180", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional start site selection at RNA polymerase III promoter", "definition": "Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. [GOC:txnOH]"}
{"concept_id": "C3271182", "aliases": ["regulation of transcriptional open complex formation at RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of transcription open complex formation at RNA polymerase II promoter", "definition": "Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. [GOC:txnOH]"}
{"concept_id": "C3271183", "aliases": ["regulation of transcription start site selection at RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of transcriptional start site selection at RNA polymerase II promoter", "definition": "Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. [GOC:txnOH]"}
{"concept_id": "C3271184", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I transcription factor binding"}
{"concept_id": "C3271186", "aliases": ["core RNA polymerase I binding transcription factor activity"], "types": ["T044"], "canonical_name": "transcription factor activity, core RNA polymerase I binding"}
{"concept_id": "C3271187", "aliases": [], "types": ["T045"], "canonical_name": "promoter clearance from RNA polymerase I promoter", "definition": "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. [GOC:txnOH]"}
{"concept_id": "C3271188", "aliases": [], "types": ["T045"], "canonical_name": "transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript", "definition": "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I. [GOC:txnOH]"}
{"concept_id": "C3271189", "aliases": [], "types": ["T045"], "canonical_name": "promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript", "definition": "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. [GOC:txnOH]"}
{"concept_id": "C3271193", "aliases": ["RNA polymerase I transcriptional preinitiation complex assembly"], "types": ["T044"], "canonical_name": "RNA polymerase I preinitiation complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter. [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]"}
{"concept_id": "C3271197", "aliases": ["maintenance of transcriptional fidelity during DNA-dependent transcription elongation", "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter"], "types": ["T045"], "canonical_name": "maintenance of transcriptional fidelity during DNA-templated transcription elongation", "definition": "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template. [GOC:txnOH]"}
{"concept_id": "C3271198", "aliases": ["maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter", "definition": "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter. [GOC:txnOH, PMID:14531857, PMID:16492753, PMID:17535246]"}
{"concept_id": "C3271200", "aliases": ["maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter"], "types": ["T045"], "canonical_name": "maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter", "definition": "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter. [GOC:txnOH]"}
{"concept_id": "C3271208", "aliases": ["RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity"}
{"concept_id": "C3271209", "aliases": ["RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding", "RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding"], "types": ["T045"], "canonical_name": "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity"}
{"concept_id": "C3271210", "aliases": ["RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding", "RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding"], "types": ["T044"], "canonical_name": "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity"}
{"concept_id": "C3271211", "aliases": ["RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding", "RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity"}
{"concept_id": "C3271213", "aliases": ["transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription"}
{"concept_id": "C3271214", "aliases": ["transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding"], "types": ["T045"], "canonical_name": "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription"}
{"concept_id": "C3271222", "aliases": ["muscarinic acetylcholine receptor binding", "G-protein coupled acetylcholine receptor binding"], "types": ["T044"], "canonical_name": "G protein-coupled acetylcholine receptor binding", "definition": "Binding to a G protein-coupled acetylcholine receptor. [GOC:bf, GOC:mah, GOC:nln]"}
{"concept_id": "C3271223", "aliases": [], "types": ["T044"], "canonical_name": "M1 muscarinic acetylcholine receptor ligand"}
{"concept_id": "C3271224", "aliases": [], "types": ["T044"], "canonical_name": "M2 muscarinic acetylcholine receptor ligand"}
{"concept_id": "C3271225", "aliases": [], "types": ["T044"], "canonical_name": "M3 muscarinic acetylcholine receptor ligand"}
{"concept_id": "C3271226", "aliases": [], "types": ["T044"], "canonical_name": "M4 muscarinic acetylcholine receptor ligand"}
{"concept_id": "C3271227", "aliases": [], "types": ["T044"], "canonical_name": "M5 muscarinic acetylcholine receptor ligand"}
{"concept_id": "C3271228", "aliases": ["dTOR/dRaptor complex location"], "types": ["T026"], "canonical_name": "dTOR/dRaptor complex"}
{"concept_id": "C3271232", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in positive regulation of conjugation with cellular fusion", "definition": "The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion. [GOC:mah]"}
{"concept_id": "C3271233", "aliases": [], "types": ["T043"], "canonical_name": "meiotic attachment of telomeric heterochromatin to spindle pole body", "definition": "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation. [GOC:pr, PMID:16615890]"}
{"concept_id": "C3271234", "aliases": [], "types": ["T043"], "canonical_name": "attachment of telomeric chromatin to spindle pole body"}
{"concept_id": "C3271235", "aliases": [], "types": ["T044"], "canonical_name": "acrosin heavy chain binding"}
{"concept_id": "C3271236", "aliases": [], "types": ["T044"], "canonical_name": "acrosin light chain binding"}
{"concept_id": "C3271237", "aliases": ["regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport"], "types": ["T043"], "canonical_name": "regulation of nucleobase-containing compound transport", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C3271238", "aliases": [], "types": ["T044"], "canonical_name": "Cdc42 signaling"}
{"concept_id": "C3271239", "aliases": ["cdc42 signalling pathway"], "types": ["T044"], "canonical_name": "Cdc42 signaling pathway"}
{"concept_id": "C3271240", "aliases": [], "types": ["T026"], "canonical_name": "ER-PM peripheral junction"}
{"concept_id": "C3271241", "aliases": [], "types": ["T045"], "canonical_name": "negative transcription elongation regulator activity"}
{"concept_id": "C3271242", "aliases": [], "types": ["T045"], "canonical_name": "positive transcription elongation regulator activity"}
{"concept_id": "C3271246", "aliases": ["down-regulation of mast cell apoptosis", "down regulation of mast cell apoptosis", "downregulation of mast cell apoptosis", "negative regulation of mast cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of mast cell apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C3271247", "aliases": ["upregulation of mast cell apoptosis", "positive regulation of mast cell apoptosis", "up regulation of mast cell apoptosis", "up-regulation of mast cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of mast cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C3271248", "aliases": ["downregulation of neutrophil apoptosis", "down-regulation of neutrophil apoptosis", "down regulation of neutrophil apoptosis", "negative regulation of neutrophil apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C3271249", "aliases": ["up-regulation of neutrophil apoptosis", "upregulation of neutrophil apoptosis", "positive regulation of neutrophil apoptosis", "up regulation of neutrophil apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil apoptotic process", "definition": "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process. [GOC:add, GOC:mtg_apoptosis]"}
{"concept_id": "C3271250", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myeloid cell apoptosis"}
{"concept_id": "C3271251", "aliases": [], "types": ["T044"], "canonical_name": "regulation of intracellular steroid hormone receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C3271252", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of intracellular steroid hormone receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C3271253", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of intracellular steroid hormone receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C3271256", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of intracellular estrogen receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. [GOC:mah]"}
{"concept_id": "C3271257", "aliases": [], "types": ["T043"], "canonical_name": "calcineurin-NFAT signaling cascade", "definition": "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679]"}
{"concept_id": "C3271258", "aliases": ["tumor necrosis factor alpha-mediated signaling pathway"], "types": ["T043"], "canonical_name": "TNF-alpha-mediated signaling pathway"}
{"concept_id": "C3271259", "aliases": ["serotonin receptor activity, coupled via Gq/11"], "types": ["T044"], "canonical_name": "Gq/11-coupled serotonin receptor activity", "definition": "Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043]"}
{"concept_id": "C3271260", "aliases": [], "types": ["T044"], "canonical_name": "adenylate cyclase inhibiting metabotropic glutamate receptor activity"}
{"concept_id": "C3271264", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of host apoptosis"}
{"concept_id": "C3271271", "aliases": ["phosphoethanolamine phosphatase activity", "phosphocholine phosphatase activity", "phosphoethanolamine phosphohydrolase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: choline phosphate + H2O = choline + phosphate. [EC:3.1.3.75]", "canonical_name": "3X11A"}
{"concept_id": "C3271272", "aliases": [], "types": ["T044"], "canonical_name": "dihydroxy fatty acid phosphatase activity"}
{"concept_id": "C3271273", "aliases": [], "types": ["T044"], "canonical_name": "hydroxy fatty acid phosphatase activity"}
{"concept_id": "C3271274", "aliases": [], "types": ["T044"], "canonical_name": "hydroxy lipid phosphatase activity"}
{"concept_id": "C3271275", "aliases": [], "types": ["T044"], "canonical_name": "lipid-phosphate phosphatase activity"}
{"concept_id": "C3271283", "aliases": ["ketoxanthophyll synthase activity"], "types": ["T044"], "canonical_name": "ketoxanthophyll synthase activity"}
{"concept_id": "C3271284", "aliases": ["up-regulation of glial cell apoptosis", "up regulation of glial cell apoptosis", "upregulation of glial cell apoptosis", "positive regulation of glial cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of glial cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. [GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C3271289", "aliases": [], "types": ["T045"], "canonical_name": "nucleobase, nucleoside, nucleotide and nucleic acid synthesis"}
{"concept_id": "C3271290", "aliases": [], "types": ["T044"], "canonical_name": "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process"}
{"concept_id": "C3271291", "aliases": [], "types": ["T044"], "canonical_name": "histone deacetylase activity (H4-K16 specific)", "definition": "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. [GOC:vw, PMID:28450737]"}
{"concept_id": "C3271292", "aliases": ["cyclohexane hydroxylase activity"], "types": ["T044"], "canonical_name": "cyclohexane monooxygenase activity", "definition": "Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O. [UM-BBD_reactionID:r1059]"}
{"concept_id": "C3271293", "aliases": [], "types": ["T045"], "canonical_name": "-C-C-A pyrophosphorylase activity"}
{"concept_id": "C3271294", "aliases": [], "types": ["T045"], "canonical_name": "CCA tRNA nucleotidyltransferase activity"}
{"concept_id": "C3271297", "aliases": [], "types": ["T045"], "canonical_name": "ribonucleic cytidylyltransferase activity"}
{"concept_id": "C3271298", "aliases": [], "types": ["T045"], "canonical_name": "transfer ribonucleate adenylyltransferase activity"}
{"concept_id": "C3271299", "aliases": [], "types": ["T045"], "canonical_name": "transfer ribonucleate cytidylyltransferase activity"}
{"concept_id": "C3271300", "aliases": [], "types": ["T045"], "canonical_name": "transfer ribonucleate nucleotidyltransferase activity"}
{"concept_id": "C3271301", "aliases": [], "types": ["T045"], "canonical_name": "transfer ribonucleic acid nucleotidyl transferase activity"}
{"concept_id": "C3271302", "aliases": [], "types": ["T045"], "canonical_name": "transfer ribonucleic adenylyl (cytidylyl) transferase activity"}
{"concept_id": "C3271303", "aliases": [], "types": ["T045"], "canonical_name": "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity"}
{"concept_id": "C3271304", "aliases": [], "types": ["T045"], "canonical_name": "transfer RNA adenylyltransferase activity"}
{"concept_id": "C3271305", "aliases": [], "types": ["T045"], "canonical_name": "transfer-RNA nucleotidyltransferase activity"}
{"concept_id": "C3271306", "aliases": [], "types": ["T045"], "canonical_name": "tRNA adenylyl(cytidylyl)transferase activity"}
{"concept_id": "C3271307", "aliases": [], "types": ["T042"], "canonical_name": "embryonic heart tube anterior/posterior pattern specification", "definition": "The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta. [GOC:bf, PMID:12435360]"}
{"concept_id": "C3271321", "aliases": ["negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP", "negative regulation of BMP signaling pathway by extracellular sequestering of BMP", "negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein", "BMP sequestration in the ECM"], "types": ["T043"], "canonical_name": "sequestering of BMP in extracellular matrix", "definition": "Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins. [GOC:BHF, PMID:20855508]"}
{"concept_id": "C3271322", "aliases": ["sequestering of TGFbeta large latency complex in extracellular matrix", "sequestering of TGFbeta LLC in extracellular matrix", "negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta", "negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta"], "types": ["T044"], "canonical_name": "sequestering of TGFbeta in extracellular matrix", "definition": "Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins. [GOC:bf, GOC:BHF, GOC:signaling, PMID:12482908, PMID:20855508]"}
{"concept_id": "C3271326", "aliases": ["envenomation resulting in modification of morphology or physiology of other organism", "envenomation resulting in modulation of process in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of process in another organism", "definition": "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism. [GOC:pamgo_curators]"}
{"concept_id": "C3271327", "aliases": ["RNA granule", "RNP granule", "mRNP granule"], "types": ["T026"], "definition": "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]", "canonical_name": "ribonucleoprotein granule"}
{"concept_id": "C3271328", "aliases": ["amacrine neuron differentiation"], "types": ["T043"], "canonical_name": "amacrine cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons. [CL:0000561, GOC:bf]"}
{"concept_id": "C3271329", "aliases": ["defecation motor program", "DMP", "defecation cycle"], "types": ["T040"], "canonical_name": "defecation rhythm", "definition": "The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated. [GOC:bf, GOC:kmv, PMID:7479775, PMID:8158250, PMID:9066270]"}
{"concept_id": "C3271330", "aliases": [], "types": ["T040"], "canonical_name": "defecation behavior"}
{"concept_id": "C3271331", "aliases": [], "types": ["T043"], "canonical_name": "enteroendocrine cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. [CL:0000164, GOC:bf]"}
{"concept_id": "C3271332", "aliases": [], "types": ["T044"], "canonical_name": "arabinan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues. [GOC:rs, ISBN:0198506732]"}
{"concept_id": "C3271333", "aliases": [], "types": ["T044"], "canonical_name": "exochitinase activity", "definition": "Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain. [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293, PMID:16298970, PMID:21390509]"}
{"concept_id": "C3271334", "aliases": ["vascular smooth muscle cell differentiation", "VSMC differentiation"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. [GOC:sl, PMID:16151017, PMID:18267954]"}
{"concept_id": "C3271335", "aliases": [], "types": ["T043"], "canonical_name": "aortic smooth muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. [GOC:sl]"}
{"concept_id": "C3271336", "aliases": ["2-hydroxyadenine deaminase activity", "2-oxoadenine deaminase activity"], "types": ["T044"], "canonical_name": "isoguanine deaminase activity", "definition": "Catalysis of the reaction: isoguanine + H2O = xanthine + NH3. [EC:3.5.4.-, GOC:imk, PMID:21604715]"}
{"concept_id": "C3271337", "aliases": [], "types": ["T042"], "canonical_name": "otolith tethering", "definition": "The attachment of a developing otolith to the kinocilia of tether cells in the inner ear. [GOC:dgh, PMID:14499652]"}
{"concept_id": "C3271340", "aliases": ["host cell exit"], "types": ["T043"], "canonical_name": "exit from host cell", "definition": "The directed movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:bf, GOC:rs, PMID:19325115]"}
{"concept_id": "C3271341", "aliases": [], "types": ["T043"], "canonical_name": "ejection from host cell"}
{"concept_id": "C3271342", "aliases": ["modulation of platelet aggregation in other organism", "modulation by organism of platelet aggregation in other organism"], "types": ["T040"], "canonical_name": "modulation of platelet aggregation in another organism", "definition": "Any process in which an organism modulates the frequency, rate or extent of platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:bf, GOC:fj, PMID:15922770]"}
{"concept_id": "C3271343", "aliases": [], "types": ["T040"], "canonical_name": "regulation of platelet aggregation in other organism"}
{"concept_id": "C3271344", "aliases": ["down-regulation of platelet aggregation in other organism", "negative regulation of platelet aggregation in other organism", "suppression of platelet aggregation in other organism", "downregulation of platelet aggregation in other organism", "inhibition of platelet aggregation in other organism"], "types": ["T043"], "canonical_name": "negative regulation of platelet aggregation in another organism", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism. [GOC:bf, GOC:fj, PMID:15922770]"}
{"concept_id": "C3271345", "aliases": ["positive regulation of platelet aggregation in other organism", "upregulation of platelet aggregation in other organism"], "types": ["T040"], "canonical_name": "positive regulation of platelet aggregation in another organism", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism. [GOC:bf, GOC:fj, PMID:11453648, PMID:18804547]"}
{"concept_id": "C3271346", "aliases": [], "types": ["T040"], "canonical_name": "up-regulation of platelet aggregation in other organism"}
{"concept_id": "C3271347", "aliases": ["modulation of mast cell degranulation in other organism", "regulation of mast cell degranulation in other organism"], "types": ["T040"], "canonical_name": "modulation of mast cell degranulation in another organism", "definition": "Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. [GOC:bf, GOC:fj, PMID:21549739]"}
{"concept_id": "C3271348", "aliases": ["upregulation of mast cell degranulation in other organism", "positive regulation of mast cell degranulation in other organism"], "types": ["T043"], "canonical_name": "positive regulation of mast cell degranulation in another organism", "definition": "Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism. [GOC:bf, GOC:fj]"}
{"concept_id": "C3271349", "aliases": [], "types": ["T043"], "canonical_name": "up-regulation of mast cell degranulation in other organism"}
{"concept_id": "C3271351", "aliases": ["parathyrin secretion", "parathormone secretion", "PTH secretion"], "types": ["T042"], "canonical_name": "parathyroid hormone secretion", "definition": "The regulated release of parathyroid hormone into the circulatory system. [GOC:cjm, PMID:12171519, PMID:21164021]"}
{"concept_id": "C3271352", "aliases": ["down-regulation of blood coagulation in other organism", "negative regulation of blood clotting in other organism", "negative regulation of blood coagulation in other organism", "suppression of blood coagulation in other organism", "downregulation of blood coagulation in other organism"], "types": ["T040"], "canonical_name": "negative regulation of blood coagulation in another organism", "definition": "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. [GOC:fj]"}
{"concept_id": "C3271353", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of blood coagulation in other organism"}
{"concept_id": "C3271354", "aliases": ["response to social isolation"], "types": ["T039"], "canonical_name": "response to isolation stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species. [GOC:bf, PMID:20203532]"}
{"concept_id": "C3271355", "aliases": ["cellular response to social isolation"], "types": ["T043"], "canonical_name": "cellular response to isolation stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species. [GOC:bf, PMID:20203532]"}
{"concept_id": "C3271356", "aliases": ["response to immobilisation stress"], "types": ["T039"], "canonical_name": "response to immobilization stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. [GOC:bf, PMID:17683801, PMID:19893991]"}
{"concept_id": "C3271357", "aliases": ["cellular response to immobilisation stress"], "types": ["T043"], "canonical_name": "cellular response to immobilization stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. [GOC:bf, PMID:17683801, PMID:19893991]"}
{"concept_id": "C3271358", "aliases": [], "types": ["T042"], "canonical_name": "aorta development", "definition": "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]"}
{"concept_id": "C3271359", "aliases": [], "types": ["T042"], "canonical_name": "ascending aorta development", "definition": "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]"}
{"concept_id": "C3271360", "aliases": [], "types": ["T042"], "canonical_name": "descending aorta development", "definition": "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]"}
{"concept_id": "C3271361", "aliases": [], "types": ["T042"], "canonical_name": "dorsal aorta development", "definition": "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]"}
{"concept_id": "C3271362", "aliases": [], "types": ["T042"], "canonical_name": "ventral aorta development", "definition": "The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604]"}
{"concept_id": "C3271363", "aliases": [], "types": ["T042"], "canonical_name": "aorta morphogenesis", "definition": "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]"}
{"concept_id": "C3271364", "aliases": [], "types": ["T042"], "canonical_name": "ascending aorta morphogenesis", "definition": "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]"}
{"concept_id": "C3271365", "aliases": [], "types": ["T042"], "canonical_name": "descending aorta morphogenesis", "definition": "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]"}
{"concept_id": "C3271366", "aliases": [], "types": ["T042"], "canonical_name": "dorsal aorta morphogenesis", "definition": "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]"}
{"concept_id": "C3271367", "aliases": [], "types": ["T042"], "canonical_name": "ventral aorta morphogenesis", "definition": "The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604]"}
{"concept_id": "C3271368", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. [CL:0000188, GOC:BHF, GOC:vk]"}
{"concept_id": "C3271369", "aliases": ["pore complex assembly in other organism", "pore complex biogenesis in other organism", "pore formation in membrane of other organism", "pore formation in other organism"], "types": ["T043"], "canonical_name": "pore formation in membrane of another organism", "definition": "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism. [GOC:bf, GOC:fj, PMID:21549739]"}
{"concept_id": "C3271370", "aliases": ["modulation of calcium channel activity in other organism"], "types": ["T038"], "canonical_name": "modulation of calcium channel activity in another organism", "definition": "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism. [GOC:bf, GOC:fj, PMID:20920515]"}
{"concept_id": "C3271371", "aliases": ["downregulation of calcium channel activity in other organism", "down-regulation of calcium channel activity in other organism", "negative regulation of calcium channel activity in other organism"], "types": ["T043"], "canonical_name": "negative regulation of calcium channel activity in another organism", "definition": "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism. [GOC:bf, GOC:fj, PMID:20920515]"}
{"concept_id": "C3271372", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcium channel activity in other organism"}
{"concept_id": "C3271373", "aliases": ["down-regulation of voltage-gated calcium channel activity in other organism", "negative regulation of voltage-dependent calcium channel activity in other organism", "negative regulation of voltage-sensitive calcium channel activity in other organism", "negative regulation of voltage-gated calcium channel activity in other organism", "negative regulation of voltage gated calcium channel activity in other organism", "downregulation of voltage-gated calcium channel activity in other organism"], "types": ["T043"], "canonical_name": "negative regulation of voltage-gated calcium channel activity in another organism", "definition": "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]"}
{"concept_id": "C3271374", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of voltage-gated calcium channel activity in other organism"}
{"concept_id": "C3271375", "aliases": ["negative regulation of low voltage-dependent calcium channel activity in other organism", "negative regulation of low voltage-gated calcium channel activity in other organism", "negative regulation of low voltage gated calcium channel activity in other organism", "down-regulation of low voltage-gated calcium channel activity in other organism", "downregulation of low voltage-gated calcium channel activity in other organism"], "types": ["T043"], "canonical_name": "negative regulation of low voltage-gated calcium channel activity in another organism", "definition": "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]"}
{"concept_id": "C3271376", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of low voltage-gated calcium channel activity in other organism"}
{"concept_id": "C3271377", "aliases": ["downregulation of high voltage-gated calcium channel activity in other organism", "negative regulation of high voltage-dependent calcium channel activity in other organism", "negative regulation of high voltage-gated calcium channel activity in other organism", "down-regulation of high voltage-gated calcium channel activity in other organism", "negative regulation of high voltage gated calcium channel activity in other organism"], "types": ["T043"], "canonical_name": "negative regulation of high voltage-gated calcium channel activity in another organism", "definition": "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]"}
{"concept_id": "C3271378", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of high voltage-gated calcium channel activity in other organism"}
{"concept_id": "C3271379", "aliases": ["desmosome dissociation"], "types": ["T043"], "canonical_name": "desmosome disassembly", "definition": "The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. [GOC:BHF, GOC:vk, ISBN:0198506732, PMID:9182671]"}
{"concept_id": "C3271380", "aliases": ["2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding"], "types": ["T044"], "canonical_name": "flurbiprofen binding", "definition": "Binding to flurbiprofen. [GOC:BHF, GOC:rl]"}
{"concept_id": "C3271381", "aliases": ["cellular response to vascular endothelial growth factor", "cellular response to VEGF"], "types": ["T043"], "canonical_name": "cellular response to vascular endothelial growth factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, PMID:18440775]"}
{"concept_id": "C3271382", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to VEGFA"}
{"concept_id": "C3271383", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to VEGFB"}
{"concept_id": "C3271384", "aliases": ["adenylate/uridylate-rich element binding", "mRNA 3'-UTR adenylate/uridylate-rich element binding"], "types": ["T045"], "canonical_name": "mRNA 3'-UTR AU-rich region binding", "definition": "Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]"}
{"concept_id": "C3271386", "aliases": [], "types": ["T043"], "canonical_name": "RNA import into mitochondrion", "definition": "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix. [GOC:ans, PMID:20691904]"}
{"concept_id": "C3271387", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic RNA import into mitochondrion"}
{"concept_id": "C3271388", "aliases": [], "types": ["T043"], "canonical_name": "nuclear-encoded RNA import into mitochondrion"}
{"concept_id": "C3271389", "aliases": [], "types": ["T043"], "canonical_name": "rRNA import into mitochondrion", "definition": "The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix. [GOC:ans, PMID:20691904]"}
{"concept_id": "C3271390", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic rRNA import into mitochondrion"}
{"concept_id": "C3271391", "aliases": [], "types": ["T043"], "canonical_name": "nuclear-encoded rRNA import into mitochondrion"}
{"concept_id": "C3271392", "aliases": [], "types": ["T042"], "canonical_name": "steroid hormone secretion", "definition": "The regulated release of any steroid that acts as a hormone into the circulatory system. [GOC:sl]"}
{"concept_id": "C3271393", "aliases": [], "types": ["T042"], "canonical_name": "corticosteroid hormone secretion", "definition": "The regulated release of any corticosteroid hormone into the circulatory system. [GOC:sl]"}
{"concept_id": "C3271394", "aliases": [], "types": ["T042"], "canonical_name": "corticosteroid secretion"}
{"concept_id": "C3271395", "aliases": [], "types": ["T042"], "canonical_name": "mineralocorticoid secretion", "definition": "The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism. [GOC:sl]"}
{"concept_id": "C3271396", "aliases": [], "types": ["T042"], "canonical_name": "aldosterone secretion", "definition": "The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. [GOC:sl]"}
{"concept_id": "C3271397", "aliases": [], "types": ["T042"], "canonical_name": "glucocorticoid secretion", "definition": "The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood. [GOC:sl]"}
{"concept_id": "C3271398", "aliases": [], "types": ["T042"], "canonical_name": "corticosterone secretion", "definition": "The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. [GOC:sl]"}
{"concept_id": "C3271399", "aliases": [], "types": ["T042"], "canonical_name": "androgen secretion", "definition": "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. [GOC:sl]"}
{"concept_id": "C3271400", "aliases": ["oestradiol secretion"], "types": ["T042"], "canonical_name": "estradiol secretion", "definition": "The regulated release of estradiol into the circulatory system. [GOC:sl, PMID:21632818]"}
{"concept_id": "C3271401", "aliases": ["VNTR binding", "microsatellite DNA binding", "variable number tandem repeat binding"], "types": ["T045"], "canonical_name": "microsatellite binding", "definition": "Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem. [GOC:yaf, PMID:21290414, SO:0000289]"}
{"concept_id": "C3271404", "aliases": ["androst-4-ene-3,17-dione secretion"], "types": ["T042"], "canonical_name": "androstenedione secretion", "definition": "The regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system. [GOC:sl]"}
{"concept_id": "C3271405", "aliases": ["3beta-hydroxyandrost-5-en-17-one secretion", "DHEA secretion", "dehydroisoandrosterone secretion"], "types": ["T042"], "canonical_name": "dehydroepiandrosterone secretion", "definition": "The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system. [GOC:sl]"}
{"concept_id": "C3271406", "aliases": ["folliculin secretion", "3-hydroxy-1,3,5(10)-estratrien-17-one secretion"], "types": ["T042"], "canonical_name": "estrone secretion", "definition": "The regulated release of estrone into the circulatory system. [GOC:sl, PMID:8395854]"}
{"concept_id": "C3271407", "aliases": [], "types": ["T038"], "canonical_name": "perforin production", "definition": "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3271408", "aliases": ["mitochondrial aberrant ncRNA catabolic process", "mitochondrial non-coding RNA surveillance", "mitochondrial ncRNA quality control"], "types": ["T045"], "canonical_name": "mitochondrial ncRNA surveillance", "definition": "The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion. [GOC:ans, PMID:19864255]"}
{"concept_id": "C3271409", "aliases": ["mitochondrial messenger RNA surveillance", "mitochondrial aberrant RNA catabolic process", "mitochondrial mRNA quality control"], "types": ["T045"], "canonical_name": "mitochondrial mRNA surveillance", "definition": "The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion. [GOC:ans, PMID:19864255]"}
{"concept_id": "C3271439", "aliases": ["response to IL-13"], "types": ["T043"], "canonical_name": "response to interleukin-13", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. [GOC:sjw, PMID:20100461]"}
{"concept_id": "C3271440", "aliases": ["cellular response to IL-13"], "types": ["T043"], "canonical_name": "cellular response to interleukin-13", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. [GOC:sjw, PMID:20100461]"}
{"concept_id": "C3271441", "aliases": ["COPI vesicle budding"], "types": ["T043"], "canonical_name": "COPI-coated vesicle budding", "definition": "The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle. [GOC:br, PMID:10052452, PMID:17041781]"}
{"concept_id": "C3271442", "aliases": ["cardiolipin acyl-chain remodelling"], "types": ["T044"], "canonical_name": "cardiolipin acyl-chain remodeling", "definition": "Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids. [GOC:bf, GOC:rb, PMID:19244244]"}
{"concept_id": "C3271443", "aliases": [], "types": ["T044"], "canonical_name": "cardiolipin maturation"}
{"concept_id": "C3271444", "aliases": [], "types": ["T044"], "canonical_name": "diphosphatidylglycerol remodeling"}
{"concept_id": "C3271445", "aliases": [], "types": ["T043"], "canonical_name": "response to topologically incorrect protein", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. [GOC:bf]"}
{"concept_id": "C3271446", "aliases": [], "types": ["T043"], "canonical_name": "response to misfolded or unfolded protein"}
{"concept_id": "C3271447", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to topologically incorrect protein", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. [GOC:bf]"}
{"concept_id": "C3271448", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to misfolded or unfolded protein"}
{"concept_id": "C3271451", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine dephosphorylation", "definition": "The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. [GOC:bf]"}
{"concept_id": "C3271452", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine dephosphorylation", "definition": "The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine. [GOC:BHF, GOC:vk, PMID:12383260]"}
{"concept_id": "C3271453", "aliases": [], "types": ["T043"], "definition": "Selective degradation of protein aggregates by macroautophagy. [GOC:autophagy, GOC:kmv, PMID:18508269, PMID:25062811]", "canonical_name": "aggrephagy"}
{"concept_id": "C3271454", "aliases": [], "types": ["T026"], "canonical_name": "meiotic spindle pole body", "definition": "The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome. [GOC:vw, PMID:21775631]"}
{"concept_id": "C3271455", "aliases": ["carbamoyl phosphate degradation", "carbamoyl phosphate catabolism", "carbamoyl phosphate breakdown"], "types": ["T044"], "canonical_name": "carbamoyl phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. [GOC:yaf, UniPathway:UPA00996]"}
{"concept_id": "C3271457", "aliases": [], "types": ["T044"], "canonical_name": "protein deglycosylation involved in glycoprotein catabolic process", "definition": "The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein. [GOC:bf, GOC:vw]"}
{"concept_id": "C3271458", "aliases": [], "types": ["T044"], "canonical_name": "histone H2A-S139 phosphorylation", "definition": "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone. [GOC:yaf, PMID:16061642]"}
{"concept_id": "C3271459", "aliases": [], "types": ["T044"], "canonical_name": "histone H2A.x phosphorylation at S139"}
{"concept_id": "C3271460", "aliases": [], "types": ["T044"], "canonical_name": "histone kinase activity (H2A-S139 specific)", "definition": "Catalysis of the transfer of a phosphate group to the serine-139 residue of the C-terminal tail of histone H2A. [GOC:yaf, PMID:16061642]"}
{"concept_id": "C3271461", "aliases": [], "types": ["T044"], "canonical_name": "histone kinase activity (H2A.x-S139 specific)"}
{"concept_id": "C3271463", "aliases": [], "types": ["T043"], "canonical_name": "tongue muscle cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell. [CL:0002673, GOC:yaf, PMID:3393851]"}
{"concept_id": "C3271465", "aliases": [], "types": ["T043"], "canonical_name": "response to trichostatin A", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus. [GOC:yaf, PMID:20181743]"}
{"concept_id": "C3271466", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to trichostatin A", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus. [GOC:yaf, PMID:20181743]"}
{"concept_id": "C3271467", "aliases": ["SAHF", "senescence-associated heterochromatin foci"], "types": ["T026"], "canonical_name": "senescence-associated heterochromatin focus", "definition": "A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes. [GOC:yaf, PMID:15621527, PMID:21248468]"}
{"concept_id": "C3271469", "aliases": ["endoderm cell differentiation"], "types": ["T043"], "canonical_name": "endodermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. [CL:0000223, GOC:yaf, PMID:17624332]"}
{"concept_id": "C3271470", "aliases": ["cartilage cell proliferation", "chondrocyte cell proliferation"], "types": ["T043"], "canonical_name": "chondrocyte proliferation", "definition": "The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. [CL:0000138, GOC:yaf, PMID:21484705]"}
{"concept_id": "C3271471", "aliases": [], "types": ["T042"], "canonical_name": "tendon development", "definition": "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. [GOC:yaf, PMID:21412429, UBERON:0000043]"}
{"concept_id": "C3271472", "aliases": [], "types": ["T042"], "canonical_name": "sinew development"}
{"concept_id": "C3271473", "aliases": ["tenocyte differentiation", "muscle attachment cell differentiation"], "types": ["T043"], "canonical_name": "tendon cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance. [CL:0000388, GOC:yaf, PMID:21412429]"}
{"concept_id": "C3271474", "aliases": ["NO sensor activity"], "types": ["T044"], "canonical_name": "nitric oxide sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO). [GOC:kmv, PMID:21491957]"}
{"concept_id": "C3271475", "aliases": [], "types": ["T042"], "canonical_name": "tendon formation", "definition": "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. [GOC:yaf, PMID:17567668, UBERON:0000043]"}
{"concept_id": "C3271476", "aliases": [], "types": ["T042"], "canonical_name": "deltoid tuberosity development", "definition": "The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase. [GOC:yaf, PMID:17567668, UBERON:0002498, Wikipedia:Deltoid_tuberosity]"}
{"concept_id": "C3271477", "aliases": [], "types": ["T040"], "canonical_name": "response to muscle stretch", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. [GOC:BHF, GOC:vk, PMID:14583192]"}
{"concept_id": "C3271478", "aliases": [], "types": ["T039"], "canonical_name": "detection of muscle stretch", "definition": "The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal. [PMID:14583192]"}
{"concept_id": "C3271479", "aliases": [], "types": ["T026"], "canonical_name": "rhabdomere microvillus", "definition": "Thin cylindrical membrane-covered projection on the surface of a rhabdomere. [GOC:bf, GOC:sart, PMID:14744998]"}
{"concept_id": "C3271480", "aliases": [], "types": ["T026"], "canonical_name": "rhabdomere microvillus membrane", "definition": "The portion of the plasma membrane surrounding a microvillus of a rhabdomere. [GOC:bf, GOC:sart, PMID:14744998]"}
{"concept_id": "C3271481", "aliases": ["7,8-dihydroneopterin 3'-triphosphate biosynthesis", "7,8-dihydroneopterin 3'-triphosphate formation", "7,8-dihydroneopterin 3'-triphosphate synthesis", "7,8-dihydroneopterin 3'-triphosphate anabolism"], "types": ["T044"], "canonical_name": "7,8-dihydroneopterin 3'-triphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate. [GOC:yaf, UniPathway:UPA00848]"}
{"concept_id": "C3271482", "aliases": [], "types": ["T044"], "canonical_name": "tetrahydrofolate interconversion", "definition": "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. [GOC:yaf, PMID:1825999, UniPathway:UPA00193]"}
{"concept_id": "C3271483", "aliases": [], "types": ["T026"], "canonical_name": "mucocyst", "definition": "A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion. [GOC:mag, PMID:10723937, PMID:4629881]"}
{"concept_id": "C3271484", "aliases": ["'de novo' pyridoxal 5'-phosphate formation", "'de novo' pyridoxal 5'-phosphate synthesis", "'de novo' pyridoxal 5'-phosphate biosynthesis", "'de novo' PLP biosynthesis", "'de novo' pyridoxal 5'-phosphate anabolism"], "types": ["T044"], "canonical_name": "'de novo' pyridoxal 5'-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components. [GOC:bf, GOC:yaf, MetaCyc:PYRIDOXSYN-PWY]"}
{"concept_id": "C3271485", "aliases": [], "types": ["T044"], "canonical_name": "'de novo' pyridoxal phosphate biosynthetic process"}
{"concept_id": "C3271486", "aliases": [], "types": ["T045"], "canonical_name": "pre-mRNA binding", "definition": "Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]"}
{"concept_id": "C3271487", "aliases": [], "types": ["T045"], "canonical_name": "protein-coding primary transcript binding"}
{"concept_id": "C3271488", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to stress", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mcc]"}
{"concept_id": "C3271489", "aliases": [], "types": ["T044"], "canonical_name": "GAF domain binding", "definition": "Binding to a GAF protein domain. [GOC:yaf, InterPro:IPR003018]"}
{"concept_id": "C3271490", "aliases": ["response to M-CSF", "response to macrophage colony-stimulating factor stimulus"], "types": ["T043"], "canonical_name": "response to macrophage colony-stimulating factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. [GOC:yaf, PMID:14687666]"}
{"concept_id": "C3271491", "aliases": ["cellular response to M-CSF stimulus", "cellular response to macrophage colony-stimulating factor"], "types": ["T043"], "canonical_name": "cellular response to macrophage colony-stimulating factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. [GOC:yaf, PMID:14687666]"}
{"concept_id": "C3271492", "aliases": [], "types": ["T026"], "canonical_name": "scintillon", "definition": "A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen. [GOC:mag, GOC:pr, PMID:4501583, PMID:5642469]"}
{"concept_id": "C3271493", "aliases": [], "types": ["T044"], "canonical_name": "sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate. [GOC:bf, GOC:dgf, MetaCyc:SUCUTIL-PWY]"}
{"concept_id": "C3271494", "aliases": [], "types": ["T044"], "canonical_name": "protein-glutamine N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine. [GOC:imk, PMID:11847124]"}
{"concept_id": "C3271495", "aliases": ["protein localization in endosome", "protein localisation in endosome"], "types": ["T043"], "canonical_name": "protein localization to endosome", "definition": "A process in which a protein is transported to, or maintained in, a location within an endosome. [GOC:yaf]"}
{"concept_id": "C3271496", "aliases": [], "types": ["T040"], "canonical_name": "imaginal disc-derived leg segmentation", "definition": "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint. [GOC:bf]"}
{"concept_id": "C3271497", "aliases": ["cyanelle inner envelope membrane"], "types": ["T026"], "canonical_name": "cyanelle inner membrane", "definition": "The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma. [GOC:aa, PMID:18976493]"}
{"concept_id": "C3271498", "aliases": [], "types": ["T026"], "canonical_name": "cyanelle outer membrane", "definition": "The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope. [GOC:aa]"}
{"concept_id": "C3271499", "aliases": ["cyanelle envelope lumen", "cyanelle periplasm"], "types": ["T026"], "canonical_name": "cyanelle intermembrane space", "definition": "The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer. [GOC:aa]"}
{"concept_id": "C3271500", "aliases": ["response to IL-3"], "types": ["T043"], "canonical_name": "response to interleukin-3", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus. [GOC:yaf]"}
{"concept_id": "C3271501", "aliases": ["cellular response to IL-3"], "types": ["T043"], "canonical_name": "cellular response to interleukin-3", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus. [GOC:yaf]"}
{"concept_id": "C3271502", "aliases": [], "types": ["T043"], "canonical_name": "response to erythropoietin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis. [GOC:yaf]"}
{"concept_id": "C3271503", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to erythropoietin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. [GOC:yaf]"}
{"concept_id": "C3271504", "aliases": [], "types": ["T026"], "canonical_name": "endolysosome", "definition": "An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. [GOC:pde, PMID:21878991]"}
{"concept_id": "C3271505", "aliases": ["endolysosomal membrane"], "types": ["T026"], "canonical_name": "endolysosome membrane", "definition": "The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. [GOC:pde]"}
{"concept_id": "C3271506", "aliases": ["endolysosomal lumen"], "types": ["T026"], "canonical_name": "endolysosome lumen", "definition": "The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. [GOC:pde]"}
{"concept_id": "C3271507", "aliases": [], "types": ["T042"], "canonical_name": "limb joint morphogenesis", "definition": "The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner. [GOC:bf]"}
{"concept_id": "C3271508", "aliases": [], "types": ["T042"], "canonical_name": "knee morphogenesis"}
{"concept_id": "C3271509", "aliases": [], "types": ["T042"], "canonical_name": "embryonic skeletal limb joint morphogenesis", "definition": "The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb. [GOC:bf, Wikipedia:Joint]"}
{"concept_id": "C3271510", "aliases": ["protein C inhibitor-transmembrane protease serine 7 complex location", "plasma serine protease inhibitor-TMPRSS7 complex location", "serpin A5-TMPRSS7 complex", "plasma serine protease inhibitor-TMPRSS7 complex", "PCI-TMPRSS7 complex", "serpin A5-TMPRSS7 complex location", "PCI-TMPRSS7 complex location", "protein C inhibitor-transmembrane protease serine 7 complex", "SERPINA5-TMPRSS7 complex", "protein C inhibitor-matriptase-3 complex", "protein C inhibitor-matriptase-3 complex location", "protein C inhibitor-TMPRSS7 complex location", "SERPINA5-TMPRSS7 complex location"], "types": ["T026"], "canonical_name": "protein C inhibitor-TMPRSS7 complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7. [GOC:ans, PMID:15853774]"}
{"concept_id": "C3271511", "aliases": ["protein C inhibitor-transmembrane protease serine 11E complex", "PCI-TMPRSS11E complex", "PCI-TMPRSS11E complex location", "protein C inhibitor-TMPRSS11E complex location", "plasma serine protease inhibitor-TMPRSS11E complex", "SERPINA5-TMPRSS11E complex location", "serpin A5-TMPRSS11E complex", "serpin A5-TMPRSS11E complex location", "SERPINA5-TMPRSS11E complex", "protein C inhibitor-transmembrane protease serine 11E complex location", "plasma serine protease inhibitor-TMPRSS11E complex location"], "types": ["T026"], "canonical_name": "protein C inhibitor-TMPRSS11E complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E. [GOC:ans, PMID:15328353]"}
{"concept_id": "C3271512", "aliases": ["protein C inhibitor-tissue-type plasminogen activator complex location", "SERPINA5-PLAT complex location", "PCI-PLAT complex", "SERPINA5-PLAT complex", "serpin A5-PLAT complex location", "protein C inhibitor-PLAT complex location", "plasma serine protease inhibitor-PLAT complex", "PCI-PLAT complex location", "protein C inhibitor-tPA complex location", "serpin A5-PLAT complex", "protein C inhibitor-tPA complex", "plasma serine protease inhibitor-PLAT complex location", "protein C inhibitor-tissue-type plasminogen activator complex"], "types": ["T026"], "canonical_name": "protein C inhibitor-PLAT complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator. [GOC:ans, PMID:10340997]"}
{"concept_id": "C3271513", "aliases": ["plasma serine protease inhibitor-PLAU complex", "serpin A5-PLAU complex", "serpin A5-PLAU complex location", "protein C inhibitor-PLAU complex location", "PCI-PLAU complex", "SERPINA5-PLAU complex", "protein C inhibitor-uPA complex", "plasma serine protease inhibitor-PLAU complex location", "protein C inhibitor-urokinase-type plasminogen activator complex", "SERPINA5-PLAU complex location", "protein C inhibitor-uPA complex location", "protein C inhibitor-U-plasminogen activator complex location", "protein C inhibitor-U-plasminogen activator complex", "PCI-PLAU complex location", "protein C inhibitor-urokinase-type plasminogen activator complex location"], "types": ["T026"], "canonical_name": "protein C inhibitor-PLAU complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator. [GOC:ans, PMID:10340997, PMID:3501295, PMID:8536714]"}
{"concept_id": "C3271514", "aliases": ["SERPINA5-thrombin complex", "protein C inhibitor-F2 complex location", "plasma serine protease inhibitor-thrombin complex location", "protein C inhibitor-thrombin complex location", "PCI-thrombin complex location", "SERPINA5-thrombin complex location", "serpin A5-thrombin complex location", "serpin A5-thrombin complex", "plasma serine protease inhibitor-thrombin complex", "protein C inhibitor-coagulation factor II complex location", "protein C inhibitor-coagulation factor II complex", "PCI-thrombin complex", "protein C inhibitor-F2 complex"], "types": ["T026"], "canonical_name": "protein C inhibitor-thrombin complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin. [GOC:ans, PMID:6323392]"}
{"concept_id": "C3271515", "aliases": ["protein C inhibitor-kallikrein-3 complex location", "serpin A5-KLK3 complex", "SERPINA5-KLK3 complex location", "SERPINA5-KLK3 complex", "plasma serine protease inhibitor-KLK3 complex location", "PCI-KLK3 complex", "protein C inhibitor-KLK3 complex location", "protein C inhibitor-prostate-specific antigen complex location", "protein C inhibitor-prostate-specific antigen complex", "serpin A5-KLK3 complex location", "plasma serine protease inhibitor-KLK3 complex", "PCI-KLK3 complex location", "protein C inhibitor-kallikrein-3 complex"], "types": ["T026"], "canonical_name": "protein C inhibitor-KLK3 complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen. [GOC:ans, PMID:1725227]"}
{"concept_id": "C3271516", "aliases": ["plasma serine protease inhibitor-plasma kallikrein complex", "SERPINA5-plasma kallikrein complex location", "serpin A5-plasma kallikrein complex location", "SERPINA5-plasma kallikrein complex", "PCI-plasma kallikrein complex location", "protein C inhibitor-KLKB1 complex", "serpin A5-plasma kallikrein complex", "protein C inhibitor-KLKB1 complex location", "plasma serine protease inhibitor-plasma kallikrein complex location", "PCI-plasma kallikrein complex", "protein C inhibitor-plasma kallikrein complex location"], "types": ["T026"], "canonical_name": "protein C inhibitor-plasma kallikrein complex", "definition": "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein. [GOC:ans, PMID:2844223, PMID:8536714]"}
{"concept_id": "C3271517", "aliases": ["capping enzyme targeting to RNA polymerase II", "recruitment of guanylyltransferase to RNA polymerase II holoenzyme complex"], "types": ["T045"], "canonical_name": "recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex", "definition": "The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript. [GOC:bf, GOC:rb, PMID:10594013]"}
{"concept_id": "C3271518", "aliases": ["neural crest cell emigration", "neural crest cell individualization"], "types": ["T043"], "canonical_name": "neural crest cell delamination", "definition": "The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube. [CL:0000333, PMID:17076275]"}
{"concept_id": "C3271519", "aliases": [], "types": ["T044"], "canonical_name": "mediator complex binding", "definition": "Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. [GOC:yaf, PMID:18391015]"}
{"concept_id": "C3271520", "aliases": [], "types": ["T044"], "canonical_name": "mediator complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. [GOC:yaf, PMID:17641689]"}
{"concept_id": "C3271521", "aliases": ["osteoclast cell development"], "types": ["T043"], "canonical_name": "osteoclast development", "definition": "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:bf, GOC:yaf]"}
{"concept_id": "C3271522", "aliases": [], "types": ["T043"], "canonical_name": "cardiac neural crest cell delamination", "definition": "The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube. [GOC:hjd, PMID:17076275, PMID:18539270, PMID:20490374]"}
{"concept_id": "C3271523", "aliases": [], "types": ["T043"], "canonical_name": "CD8-positive, alpha-beta T cell activation", "definition": "The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [CL:0000625, GOC:yaf]"}
{"concept_id": "C3271524", "aliases": ["TCTN-B9D complex location"], "types": ["T026"], "canonical_name": "TCTN-B9D complex"}
{"concept_id": "C3271525", "aliases": ["B9 complex location"], "types": ["T026"], "canonical_name": "B9 complex"}
{"concept_id": "C3271526", "aliases": ["tectonic complex location"], "types": ["T026"], "canonical_name": "tectonic complex"}
{"concept_id": "C3271527", "aliases": ["tectonic-like complex location"], "types": ["T026"], "canonical_name": "tectonic-like complex"}
{"concept_id": "C3271528", "aliases": ["(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolism", "diferuloylmethane metabolic process", "diferuloylmethane metabolism", "turmeric yellow metabolism", "curcumin metabolism", "turmeric yellow metabolic process", "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolic process"], "types": ["T044"], "canonical_name": "curcumin metabolic process", "definition": "The chemical reactions and pathways involving the polyphenol, curcumin. [PMID:21467222]"}
{"concept_id": "C3271529", "aliases": ["(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione breakdown", "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolism", "turmeric yellow degradation", "curcumin catabolism", "curcumin breakdown", "turmeric yellow catabolic process", "curcumin degradation", "turmeric yellow catabolism", "turmeric yellow breakdown", "diferuloylmethane degradation", "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione degradation", "diferuloylmethane breakdown", "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolic process", "diferuloylmethane catabolism", "diferuloylmethane catabolic process"], "types": ["T040"], "canonical_name": "curcumin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the polyphenol, curcumin. [PMID:21467222]"}
{"concept_id": "C3271530", "aliases": ["long chain fatty acid binding"], "types": ["T044"], "canonical_name": "long-chain fatty acid binding", "definition": "Binding to a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [GOC:pm, PMID:12641450]"}
{"concept_id": "C3271531", "aliases": ["long-chain fatty acyl-coenyme A binding"], "types": ["T044"], "canonical_name": "long-chain fatty acyl-CoA binding", "definition": "Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. [GOC:krc, GOC:pm]"}
{"concept_id": "C3271532", "aliases": [], "types": ["T044"], "canonical_name": "protein demalonylation", "definition": "The removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide. [GOC:sp, PMID:22076378]"}
{"concept_id": "C3271533", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine demalonylation", "definition": "The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein. [GOC:sp, PMID:22076378]"}
{"concept_id": "C3271534", "aliases": [], "types": ["T044"], "canonical_name": "protein desuccinylation", "definition": "The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein. [GOC:sp, PMID:22076378]"}
{"concept_id": "C3271535", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine desuccinylation", "definition": "The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein. [GOC:sp, PMID:22076378]"}
{"concept_id": "C3271536", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine succinylation", "definition": "The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine. [GOC:jsg, GOC:sp, PMID:21151122, RESID:AA0545]"}
{"concept_id": "C3271537", "aliases": ["protein localisation to trailing edge"], "types": ["T043"], "canonical_name": "protein localization to trailing edge", "definition": "A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement. [GOC:pf, GOC:pg]"}
{"concept_id": "C3271538", "aliases": ["protein localisation to uropod"], "types": ["T043"], "canonical_name": "protein localization to uropod", "definition": "A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell. [GOC:add, GOC:pf, ISBN:0781735149, PMID:12714569, PMID:12787750]"}
{"concept_id": "C3271539", "aliases": ["glomerular endothelial cell fenestration", "GEnC fenestration"], "types": ["T026"], "canonical_name": "glomerular endothelium fenestra", "definition": "A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes. [GOC:cjm, MP:0011454, PMID:19129259]"}
{"concept_id": "C3271540", "aliases": ["protein malonyl lysine demalonylation activity", "protein lysine demalonylation activity", "peptidyl-malonyllysine demalonylase activity"], "types": ["T044"], "canonical_name": "protein-malonyllysine demalonylase activity", "definition": "Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide. [GOC:sp, PMID:21908771, PMID:22076378]"}
{"concept_id": "C3271541", "aliases": ["peptidyl-succinyllysine desuccinylase activity"], "types": ["T044"], "canonical_name": "protein-succinyllysine desuccinylase activity", "definition": "Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. [GOC:sp, PMID:22076378]"}
{"concept_id": "C3271542", "aliases": [], "types": ["T044"], "canonical_name": "succinyl lysine desuccinylase activity"}
{"concept_id": "C3271543", "aliases": [], "types": ["T044"], "canonical_name": "succinyllysine desuccinylase activity"}
{"concept_id": "C3271544", "aliases": [], "types": ["T030"], "canonical_name": "filtration diaphragm", "definition": "A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph. [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]"}
{"concept_id": "C3271545", "aliases": [], "types": ["T030"], "canonical_name": "slit diaphragm", "definition": "A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. [GOC:mtg_kidney_jan10, GOC:rph, PMID:12386277, PMID:15994232, PMID:18971929, PMID:19478094]"}
{"concept_id": "C3271546", "aliases": [], "types": ["T043"], "canonical_name": "filtration diaphragm assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph. [GOC:mtg_kidney_jan10, PMID:18971929]"}
{"concept_id": "C3271547", "aliases": [], "types": ["T043"], "canonical_name": "nephrocyte diaphragm assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney. [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]"}
{"concept_id": "C3271548", "aliases": [], "types": ["T043"], "canonical_name": "slit diaphragm assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. [GOC:mtg_kidney_jan10, GOC:rph, PMID:20633639]"}
{"concept_id": "C3271549", "aliases": ["muscle cell chemotaxis towards tendon cell"], "types": ["T043"], "canonical_name": "muscle cell chemotaxis toward tendon cell", "definition": "The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells. [GOC:sart, PMID:19793885]"}
{"concept_id": "C3271550", "aliases": [], "types": ["T043"], "canonical_name": "muscle cell attraction"}
{"concept_id": "C3271551", "aliases": ["pre-synaptic periactive zone", "periactive zone"], "types": ["T026"], "canonical_name": "presynaptic periactive zone", "definition": "A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development. [GOC:sart, PMID:10976048, PMID:18439406]"}
{"concept_id": "C3271552", "aliases": ["spermatid acroblast"], "types": ["T026"], "canonical_name": "acroblast", "definition": "A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle. [GOC:sart, PMID:19934220]"}
{"concept_id": "C3271553", "aliases": [], "types": ["T044"], "canonical_name": "fucosylation", "definition": "The covalent attachment of a fucosyl group to an acceptor molecule. [GOC:sart, PMID:19948734]"}
{"concept_id": "C3271554", "aliases": [], "types": ["T044"], "canonical_name": "protein O-linked fucosylation", "definition": "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage. [GOC:sart, PMID:19948734]"}
{"concept_id": "C3271555", "aliases": ["light-dependent chlorophyll formation", "light-dependent chlorophyll biosynthesis", "light dependent chlorophyll biosynthetic process", "light-dependent chlorophyll anabolism", "light-dependent chlorophyll synthesis"], "types": ["T044"], "canonical_name": "light-dependent chlorophyll biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light. [GOC:yaf, PMID:12242396]"}
{"concept_id": "C3271556", "aliases": ["light-independent chlorophyll synthesis", "light-independent chlorophyll biosynthesis", "light independent chlorophyll biosynthetic process", "light-independent chlorophyll formation", "light-independent chlorophyll anabolism"], "types": ["T044"], "canonical_name": "light-independent chlorophyll biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light. [GOC:yaf, PMID:12242396, UniPathway:UPA00670]"}
{"concept_id": "C3271557", "aliases": ["light-dependent bacteriochlorophyll synthesis", "light-dependent bacteriochlorophyll biosynthesis", "light-dependent bacteriochlorophyll formation", "light dependent bacteriochlorophyll biosynthetic process", "light-dependent bacteriochlorophyll anabolism"], "types": ["T044"], "canonical_name": "light-dependent bacteriochlorophyll biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants. [GOC:yaf, PMID:12242396]"}
{"concept_id": "C3271558", "aliases": ["light-independent bacteriochlorophyll synthesis", "light independent bacteriochlorophyll biosynthetic process", "light-independent bacteriochlorophyll formation", "light-independent bacteriochlorophyll anabolism", "light-independent bacteriochlorophyll biosynthesis"], "types": ["T044"], "canonical_name": "light-independent bacteriochlorophyll biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants. [GOC:yaf, PMID:12242396, UniPathway:UPA00671]"}
{"concept_id": "C3271559", "aliases": [], "types": ["T044"], "canonical_name": "N-glycan fucosylation", "definition": "The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains. [GOC:sart, PMID:19948734]"}
{"concept_id": "C3271560", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein fucosylation"}
{"concept_id": "C3271561", "aliases": [], "types": ["T044"], "canonical_name": "direct ossification", "definition": "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. [GO_REF:0000034]"}
{"concept_id": "C3271562", "aliases": [], "types": ["T042"], "canonical_name": "perichondral ossification", "definition": "Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage. [GO_REF:0000034]"}
{"concept_id": "C3271563", "aliases": ["indirect ossification"], "types": ["T044"], "canonical_name": "replacement ossification", "definition": "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. [GO_REF:0000034]"}
{"concept_id": "C3271564", "aliases": [], "types": ["T044"], "canonical_name": "ligamentous ossification", "definition": "Ossification wherein bone tissue forms within ligamentous tissue. [GO_REF:0000034]"}
{"concept_id": "C3271565", "aliases": [], "types": ["T044"], "canonical_name": "intratendonous ossification", "definition": "Ossification wherein bone tissue forms within tendonous tissue. [GO_REF:0000034]"}
{"concept_id": "C3271566", "aliases": [], "types": ["T043"], "canonical_name": "minus-end specific microtubule depolymerization", "definition": "The removal of tubulin heterodimers from the minus end of a microtubule. [GOC:sart, PMID:17452528]"}
{"concept_id": "C3271567", "aliases": [], "types": ["T043"], "canonical_name": "purine nucleotide-sugar transport"}
{"concept_id": "C3271568", "aliases": [], "types": ["T044"], "canonical_name": "purine nucleotide-sugar transmembrane transporter activity", "definition": "Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:sart, PMID:19948734]"}
{"concept_id": "C3271569", "aliases": [], "types": ["T044"], "canonical_name": "extracellular ammonia-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts. [GOC:sart, PMID:19135896]"}
{"concept_id": "C3271570", "aliases": [], "types": ["T044"], "canonical_name": "ionotropic ammonia receptor activity"}
{"concept_id": "C3271571", "aliases": [], "types": ["T044"], "canonical_name": "extracellular phenylacetaldehyde-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts. [GOC:sart, PMID:19135896]"}
{"concept_id": "C3271572", "aliases": [], "types": ["T044"], "canonical_name": "ionotropic phenylacetaldehyde receptor activity"}
{"concept_id": "C3271574", "aliases": ["GDP-fucose transport into endoplasmic reticulum lumen", "GDP-fucose transport across endoplasmic reticulum membrane", "GDP-fucose import into endoplasmic reticulum"], "types": ["T043"], "canonical_name": "GDP-fucose import into endoplasmic reticulum lumen", "definition": "The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. [GOC:sart, PMID:3458237]"}
{"concept_id": "C3271575", "aliases": ["GDP-fucose transport into Golgi lumen", "GDP-fucose import into Golgi", "GDP-fucose transport across Golgi membrane"], "types": ["T043"], "canonical_name": "GDP-fucose import into Golgi lumen", "definition": "The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. [GOC:sart, PMID:3458237]"}
{"concept_id": "C3271576", "aliases": ["positive regulation of transcription from RNA polymerase II promoter in response to iron deficiency"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions. [GOC:cjk]"}
{"concept_id": "C3271577", "aliases": ["glutathione synthetase complex", "glutathione synthase complex location", "glutathione synthetase complex location"], "types": ["T026"], "canonical_name": "glutathione synthase complex", "definition": "A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer. [GOC:al, PMID:12734194, PMID:14990577, PMID:1958212]"}
{"concept_id": "C3271578", "aliases": ["D-serine catabolism", "D-serine breakdown", "D-serine degradation"], "types": ["T044"], "canonical_name": "D-serine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:imk]"}
{"concept_id": "C3271579", "aliases": [], "types": ["T043"], "canonical_name": "cleavage furrow formation", "definition": "Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell. [GOC:ans, PMID:15811947, PMID:20687468, PMID:2192590]"}
{"concept_id": "C3271580", "aliases": [], "types": ["T043"], "canonical_name": "cleavage furrow positioning"}
{"concept_id": "C3271581", "aliases": ["cleavage furrow contraction"], "types": ["T043"], "canonical_name": "cleavage furrow ingression", "definition": "Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed. [PMID:15811947, PMID:20687468]"}
{"concept_id": "C3271582", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:rn, PMID:14978214, PMID:18439143]"}
{"concept_id": "C3271583", "aliases": ["PI(3)P biosynthesis", "phosphatidylinositol-3-phosphate formation", "phosphatidylinositol-3-phosphate synthesis", "PtdIns3P biosynthesis", "phosphatidylinositol-3-phosphate biosynthesis", "phosphatidylinositol-3-phosphate anabolism"], "types": ["T044"], "canonical_name": "phosphatidylinositol-3-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. [GOC:al, GOC:vw]"}
{"concept_id": "C3271584", "aliases": [], "types": ["T043"], "canonical_name": "germ cell proliferation", "definition": "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. [CL:0000586, GOC:kmv]"}
{"concept_id": "C3271585", "aliases": [], "types": ["T044"], "canonical_name": "small molecule binding", "definition": "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:pde, GOC:pm]"}
{"concept_id": "C3271590", "aliases": [], "types": ["T045"], "canonical_name": "pre-miRNA 3'-end processing", "definition": "OBSOLETE. Any process involved in forming the mature 3' end of a miRNA from a pre-miRNA. [GOC:sart, PMID:22055292]"}
{"concept_id": "C3271591", "aliases": ["miRNA 3'-end processing", "miRNA 3' end terminal trimming", "miRNA trimming"], "types": ["T045"], "canonical_name": "mature miRNA 3'-end processing"}
{"concept_id": "C3271592", "aliases": [], "types": ["T040"], "canonical_name": "male germ-line stem cell population maintenance", "definition": "The process by which an organism or tissue maintains a population of male germ-line stem cells. [GOC:sart, PMID:21752937]"}
{"concept_id": "C3271593", "aliases": [], "types": ["T040"], "canonical_name": "female germ-line stem cell population maintenance", "definition": "The process by which an organism or tissue maintains a population of female germ-line stem cells. [GOC:sart]"}
{"concept_id": "C3271594", "aliases": ["leukotriene B4 degradation", "leukotriene B4 breakdown", "LTB4 catabolism", "leukotriene B4 catabolism"], "types": ["T044"], "canonical_name": "leukotriene B4 catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. [GOC:yaf, PMID:9799565, UniPathway:UPA00883]"}
{"concept_id": "C3271595", "aliases": ["LTB4 metabolism"], "types": ["T044"], "canonical_name": "leukotriene B4 metabolic process", "definition": "The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. [GOC:bf]"}
{"concept_id": "C3271596", "aliases": ["Kdo2-lipid A metabolism"], "types": ["T044"], "canonical_name": "Kdo2-lipid A metabolic process", "definition": "The chemical reactions and pathways involving Kdo2-lipid A, a lipopolysaccharide (LPS) component. [GOC:bf]"}
{"concept_id": "C3271597", "aliases": ["Kdo2-lipid A anabolism", "KDO(2)-lipid A biosynthesis", "Kdo2-lipid A synthesis", "di[3-deoxy-D-manno-octulosonyl]-lipid A biosynthesis", "Kdo2-lipid A formation", "Kdo2-lipid A biosynthesis"], "types": ["T044"], "canonical_name": "Kdo2-lipid A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component. [GOC:yaf, UniPathway:UPA00360]"}
{"concept_id": "C3271598", "aliases": ["class 1 mPTS binding"], "types": ["T044"], "canonical_name": "peroxisome membrane class-1 targeting sequence binding", "definition": "Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner. [GOC:pm, PMID:14709540, PMID:17020786]"}
{"concept_id": "C3271599", "aliases": [], "types": ["T044"], "canonical_name": "PEX19-dependent mPTS binding"}
{"concept_id": "C3271600", "aliases": ["class 2 mPTS binding"], "types": ["T044"], "canonical_name": "peroxisome membrane class-2 targeting sequence binding", "definition": "Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner. [GOC:pm, PMID:14709540, PMID:17020786]"}
{"concept_id": "C3271601", "aliases": [], "types": ["T044"], "canonical_name": "PEX19-independent mPTS binding"}
{"concept_id": "C3271602", "aliases": ["undecaprenyl phosphate alpha-L-Ara4N metabolism", "4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate metabolic process"], "types": ["T044"], "canonical_name": "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process", "definition": "The chemical reactions and pathways involving 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N). [PMID:15695810]"}
{"concept_id": "C3271603", "aliases": ["4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate synthesis", "undecaprenyl phosphate alpha-L-Ara4N biosynthesis", "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate formation", "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthesis", "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate anabolism"], "types": ["T044"], "canonical_name": "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N). [GOC:yaf, PMID:15695810, UniPathway:UPA00036]"}
{"concept_id": "C3271604", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to inositol starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol. [GOC:al, PMID:19606215]"}
{"concept_id": "C3271605", "aliases": ["very long-chain fatty acyl CoA metabolic process", "very long-chain fatty acyl-CoA metabolism"], "types": ["T044"], "canonical_name": "very long-chain fatty-acyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. [GOC:pm]"}
{"concept_id": "C3271606", "aliases": ["medium-chain fatty acyl CoA metabolic process", "medium-chain fatty acyl-CoA metabolism"], "types": ["T044"], "canonical_name": "medium-chain fatty-acyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12. [GOC:pm]"}
{"concept_id": "C3271607", "aliases": ["very long-chain fatty-acyl-CoA breakdown", "very long-chain fatty-acyl-CoA catabolism", "very long-chain fatty-acyl-CoA degradation"], "types": ["T044"], "canonical_name": "very long-chain fatty-acyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. [GOC:pm]"}
{"concept_id": "C3271608", "aliases": ["medium-chain fatty-acyl-CoA breakdown", "medium-chain fatty-acyl-CoA catabolism", "medium-chain fatty-acyl-CoA degradation"], "types": ["T044"], "canonical_name": "medium-chain fatty-acyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12. [GOC:pm]"}
{"concept_id": "C3271609", "aliases": ["fatty-acyl-CoA catabolism", "fatty-acyl-CoA degradation", "fatty-acyl-CoA breakdown"], "types": ["T044"], "canonical_name": "fatty-acyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. [PMID:10578051]"}
{"concept_id": "C3271610", "aliases": ["long-chain fatty-acyl-CoA breakdown", "long-chain fatty-acyl-CoA catabolism", "long-chain fatty-acyl-CoA degradation"], "types": ["T044"], "canonical_name": "long-chain fatty-acyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [GOC:pm]"}
{"concept_id": "C3271611", "aliases": ["HA cable"], "types": ["T026"], "canonical_name": "hyaluranon cable", "definition": "A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan. [GOC:yaf, PMID:16900089]"}
{"concept_id": "C3271612", "aliases": ["HA cable assembly"], "types": ["T043"], "canonical_name": "hyaluranon cable assembly", "definition": "A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan. [GOC:yaf, PMID:16900089]"}
{"concept_id": "C3271613", "aliases": ["response to PDGF stimulus", "response to platelet-derived growth factor stimulus"], "types": ["T043"], "canonical_name": "response to platelet-derived growth factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. [GOC:yaf]"}
{"concept_id": "C3271614", "aliases": ["cellular response to PDGF stimulus"], "types": ["T043"], "canonical_name": "cellular response to platelet-derived growth factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. [GOC:yaf]"}
{"concept_id": "C3271615", "aliases": ["dsDNA-dependent ATP-dependent DNA helicase activity", "double-stranded DNA-dependent ATP-dependent DNA helicase activity", "double-stranded DNA-dependent ATPase activity", "dsDNA-dependent ATPase activity"], "types": ["T045"], "canonical_name": "double-stranded DNA helicase activity", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix. [GOC:kmv]"}
{"concept_id": "C3271616", "aliases": ["bone morphogenetic protein binding"], "types": ["T044"], "canonical_name": "BMP binding", "definition": "Binding to a member of the bone morphogenetic protein (BMP) family. [GOC:BHF, PMID:9660951]"}
{"concept_id": "C3271617", "aliases": ["histone lysine H3 K9 dimethylation", "histone H3 K9 dimethylation"], "types": ["T044"], "canonical_name": "histone H3-K9 dimethylation", "definition": "The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone. [GOC:vw]"}
{"concept_id": "C3271618", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K9 trimethylation", "definition": "The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone. [GOC:vw]"}
{"concept_id": "C3271619", "aliases": ["cysteine sulfinate binding"], "types": ["T044"], "canonical_name": "3-sulfino-L-alanine binding", "definition": "Binding to 3-sulfino-L-alanine (cysteine sulfinate). [GOC:al, PMID:8346915]"}
{"concept_id": "C3271620", "aliases": ["CatSper channel complex location", "CATSPER channel", "CatSper complex location", "CatSper channel complex"], "types": ["T026"], "canonical_name": "CatSper complex", "definition": "A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits. [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039]"}
{"concept_id": "C3271622", "aliases": ["PGH2 9,11-endoperoxidase", "PGH2 9-,11-endoperoxide reductase"], "types": ["T044"], "canonical_name": "prostaglandin H2 endoperoxidase reductase activity", "definition": "Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate). [GOC:mw, KEGG_REACTION:R02264, PMID:10622721, PMID:14979715, PMID:16475787]"}
{"concept_id": "C3271623", "aliases": ["NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity"], "types": ["T044"], "canonical_name": "11-hydroxythromboxane B2 dehydrogenase activity", "definition": "Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+. [GOC:mw, KEGG_REACTION:R05060, PMID:3461463, PMID:3823488, PMID:8200461]"}
{"concept_id": "C3271624", "aliases": [], "types": ["T044"], "canonical_name": "12-hydroxyheptadecatrienoic acid synthase activity", "definition": "Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA). [GOC:mw, PMID:11297515]"}
{"concept_id": "C3271625", "aliases": [], "types": ["T044"], "canonical_name": "prostaglandin H2 degradation activity"}
{"concept_id": "C3271626", "aliases": [], "types": ["T043"], "canonical_name": "Schwann cell migration", "definition": "The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function. [CL:0002573, PMID:20335460]"}
{"concept_id": "C3271627", "aliases": ["L-kynurenine-oxaloacetate transaminase activity"], "types": ["T044"], "canonical_name": "kynurenine-oxaloacetate transaminase activity", "definition": "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate. [EC:2.6.1.-, GOC:pde, PMID:15606768, PMID:4149765]"}
{"concept_id": "C3271628", "aliases": [], "types": ["T044"], "canonical_name": "kynurenine-oxo-acid transaminase activity"}
{"concept_id": "C3271629", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine hydroxylation", "definition": "The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine. [GOC:reh, PMID:21251231]"}
{"concept_id": "C3271630", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine dioxygenase activity", "definition": "Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2. [GOC:reh, PMID:21251231]"}
{"concept_id": "C3271631", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-asparagine 3-dioxygenase activity", "definition": "Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2. [GOC:reh, PMID:12215170]"}
{"concept_id": "C3271632", "aliases": ["L-phenylalanine:oxaloacetate transaminase activity"], "types": ["T044"], "canonical_name": "L-phenylalanine-oxaloacetate transaminase activity", "definition": "Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate. [GOC:pde, PMID:15606768]"}
{"concept_id": "C3271633", "aliases": ["flagellum movement"], "types": ["T043"], "canonical_name": "flagellar movement"}
{"concept_id": "C3271634", "aliases": [], "types": ["T044"], "canonical_name": "kringle domain binding", "definition": "Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors. [GOC:yaf, Wikipedia:Kringle_domain]"}
{"concept_id": "C3271635", "aliases": [], "types": ["T043"], "canonical_name": "regulation of flagellum beat frequency"}
{"concept_id": "C3271636", "aliases": ["DC homeostasis"], "types": ["T043"], "canonical_name": "dendritic cell homeostasis", "definition": "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316]"}
{"concept_id": "C3271637", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to mycotoxin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi. [GOC:di, PMID:20548963]"}
{"concept_id": "C3271638", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylglycerol acyl-chain remodeling", "definition": "Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. [GOC:mw, PMID:15485873, PMID:18458083]"}
{"concept_id": "C3271639", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol acyl-chain remodeling", "definition": "Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains. [GOC:mw, PMID:18094042, PMID:18772128]"}
{"concept_id": "C3271640", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylserine acyl-chain remodeling", "definition": "Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18287005, PMID:18458083]"}
{"concept_id": "C3271641", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidyl-L-serine acyl-chain remodeling"}
{"concept_id": "C3271642", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine acyl-chain remodeling", "definition": "Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18195019, PMID:18458083]"}
{"concept_id": "C3271643", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylethanolamine acyl-chain remodeling", "definition": "Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18287005, PMID:18458083]"}
{"concept_id": "C3271644", "aliases": ["triacylglycerol acyl-chain remodeling"], "types": ["T044"], "canonical_name": "triglyceride acyl-chain remodeling", "definition": "Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains. [GOC:mw, PMID:15364929]"}
{"concept_id": "C3271645", "aliases": ["diglyceride acyl-chain remodeling"], "types": ["T044"], "canonical_name": "diacylglycerol acyl-chain remodeling", "definition": "Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains. [GOC:mw, PMID:15364929]"}
{"concept_id": "C3271646", "aliases": ["glyceride acyl-chain remodeling"], "types": ["T044"], "canonical_name": "acylglycerol acyl-chain remodeling", "definition": "Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains. [GOC:mw, PMID:15364929]"}
{"concept_id": "C3271647", "aliases": ["inner dynein arm complex", "inner dynein arm complex location"], "types": ["T026"], "canonical_name": "inner dynein arm", "definition": "Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. [GOC:BHF, GOC:vk, PMID:19347929, PMID:2557057, PMID:7962092]"}
{"concept_id": "C3271648", "aliases": ["outer dynein arm complex location", "outer dynein arm complex"], "types": ["T026"], "canonical_name": "outer dynein arm", "definition": "Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. [GOC:BHF, GOC:vk, PMID:2557057, PMID:6218174]"}
{"concept_id": "C3271649", "aliases": ["ODA assembly"], "types": ["T044"], "canonical_name": "outer dynein arm assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. [GOC:BHF, GOC:vk, PMID:19944400]"}
{"concept_id": "C3271650", "aliases": ["IDA assembly"], "types": ["T044"], "canonical_name": "inner dynein arm assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. [GOC:BHF, GOC:vk, PMID:19944400]"}
{"concept_id": "C3271651", "aliases": ["MSH secretion"], "types": ["T043"], "canonical_name": "melanocyte-stimulating hormone secretion", "definition": "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation. [GOC:cjm, Wikipedia:Melanocyte-stimulating_hormone]"}
{"concept_id": "C3271652", "aliases": [], "types": ["T043"], "canonical_name": "calcitonin secretion", "definition": "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell. [GOC:cjm]"}
{"concept_id": "C3271653", "aliases": [], "types": ["T043"], "canonical_name": "oxytocin secretion"}
{"concept_id": "C3271654", "aliases": [], "types": ["T044"], "canonical_name": "3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity", "definition": "Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2. [GOC:mw, KEGG_REACTION:R06866, PMID:620805, PMID:7028108]"}
{"concept_id": "C3271655", "aliases": [], "types": ["T043"], "canonical_name": "cell-abiotic substrate adhesion", "definition": "The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules. [GOC:di]"}
{"concept_id": "C3271656", "aliases": [], "types": ["T043"], "canonical_name": "cell-abiotic surface adhesion"}
{"concept_id": "C3271657", "aliases": ["invasive growth in response to elevated temperature", "invasive growth in response to high temperature"], "types": ["T043"], "canonical_name": "invasive growth in response to heat", "definition": "The growth of colonies in filamentous chains of cells as a result of an increase in temperature. [GOC:di, PMID:22365851]"}
{"concept_id": "C3271658", "aliases": [], "types": ["T043"], "canonical_name": "invasive growth in response to temperature stimulus"}
{"concept_id": "C3271659", "aliases": [], "types": ["T039"], "canonical_name": "phenotypic switching", "definition": "A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues. [GOC:bf, GOC:di, PMID:12443899, PMID:22406749, PMID:8456504, Wikipedia:Phenotypic_switching]"}
{"concept_id": "C3271660", "aliases": [], "types": ["T039"], "canonical_name": "phenotypic dimorphism"}
{"concept_id": "C3271661", "aliases": [], "types": ["T043"], "canonical_name": "phenotypic switching in response to host", "definition": "A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. [GOC:di, PMID:16696644, Wikipedia:Phenotypic_switching]"}
{"concept_id": "C3271662", "aliases": [], "types": ["T040"], "canonical_name": "filamentous growth of a population of unicellular organisms in response to heat", "definition": "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature. [GOC:di, PMID:17554048]"}
{"concept_id": "C3271663", "aliases": [], "types": ["T044"], "canonical_name": "3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity", "definition": "Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2. [GOC:mw, PMID:620805, PMID:7028108]"}
{"concept_id": "C3271664", "aliases": [], "types": ["T043"], "canonical_name": "filamentous growth of a population of unicellular organisms in response to starvation", "definition": "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment. [GOC:di, PMID:17554048]"}
{"concept_id": "C3271665", "aliases": [], "types": ["T043"], "canonical_name": "filamentous growth of a population of unicellular organisms in response to chemical stimulus", "definition": "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus. [GOC:di, PMID:17554048]"}
{"concept_id": "C3271666", "aliases": [], "types": ["T045"], "canonical_name": "thiamine salvage", "definition": "A process that generates thiamine (vitamin B1) from derivatives of it without de novo synthesis. [PMID:15150256, PMID:16952958]"}
{"concept_id": "C3271667", "aliases": [], "types": ["T044"], "canonical_name": "thiosulfate binding", "definition": "Binding to a thiosulfate, a sulfur oxide that has formula O3S2. [GOC:db, PMID:2188959]"}
{"concept_id": "C3271668", "aliases": ["sBMO"], "types": ["T044"], "canonical_name": "soluble butane monooxygenase"}
{"concept_id": "C3271669", "aliases": [], "types": ["T044"], "canonical_name": "ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor", "definition": "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin. [EC:1.17.4.1, GOC:bf, GOC:pde, PMID:7476363]"}
{"concept_id": "C3271670", "aliases": [], "types": ["T040"], "canonical_name": "response to neutral pH", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:di, Wikipedia:PH]"}
{"concept_id": "C3271671", "aliases": [], "types": ["T043"], "canonical_name": "filamentous growth of a population of unicellular organisms in response to pH", "definition": "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:di, Wikipedia:PH]"}
{"concept_id": "C3271672", "aliases": [], "types": ["T040"], "canonical_name": "filamentous growth of a population of unicellular organisms in response to neutral pH", "definition": "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus. [GOC:di, PMID:6374461]"}
{"concept_id": "C3271673", "aliases": [], "types": ["T043"], "canonical_name": "osteoclast maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes. [CL:0000092, GOC:pg]"}
{"concept_id": "C3271674", "aliases": [], "types": ["T043"], "canonical_name": "chondroclast maturation"}
{"concept_id": "C3271675", "aliases": [], "types": ["T043"], "canonical_name": "filamentous growth of a population of unicellular organisms in response to biotic stimulus", "definition": "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus. [GOC:di]"}
{"concept_id": "C3271676", "aliases": ["protein localisation to linear element"], "types": ["T043"], "canonical_name": "protein localization to linear element", "definition": "A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. [GOC:mah, PMID:19756689]"}
{"concept_id": "C3271677", "aliases": ["EGFR ligand maturation"], "types": ["T043"], "canonical_name": "epidermal growth factor receptor ligand maturation", "definition": "Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor. [GOC:signaling, PMID:11672524, PMID:11672525]"}
{"concept_id": "C3271678", "aliases": [], "types": ["T044"], "canonical_name": "peptide bond cleavage involved in epidermal growth factor receptor ligand maturation"}
{"concept_id": "C3271679", "aliases": ["netrin receptor activity involved in positive chemotaxis", "attractive netrin receptor activity"], "types": ["T044"], "canonical_name": "netrin receptor activity involved in chemoattraction", "definition": "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin. [GOC:signaling]"}
{"concept_id": "C3271680", "aliases": ["netrin-activated signal transduction pathway", "netrin signaling pathway", "netrin-activated signalling pathway", "netrin-mediated signaling pathway"], "types": ["T044"], "canonical_name": "netrin-activated signaling pathway", "definition": "The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance. [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]"}
{"concept_id": "C3271681", "aliases": ["TRAF-mediated signalling", "TRAF-mediated intracellular signaling", "TRAF signaling", "tumor necrosis factor receptor-associated factor signal transduction", "TRAF-mediated signaling", "tumor necrosis factor receptor-associated factor signaling"], "types": ["T044"], "canonical_name": "TRAF-mediated signal transduction", "definition": "The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components. [GOC:bf, PMID:19918944, PMID:20596822]"}
{"concept_id": "C3271682", "aliases": ["regulation of signaling pathway by receptor endocytosis"], "types": ["T044"], "canonical_name": "regulation of signal transduction by receptor internalization", "definition": "Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway. [GOC:bf, GOC:signaling, PMID:17011816, PMID:19696798]"}
{"concept_id": "C3271683", "aliases": ["positive regulation of signaling pathway by receptor endocytosis"], "types": ["T044"], "canonical_name": "positive regulation of signal transduction by receptor internalization", "definition": "Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms. [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798]"}
{"concept_id": "C3271684", "aliases": ["negative regulation of signaling pathway by receptor endocytosis"], "types": ["T044"], "canonical_name": "negative regulation of signal transduction by receptor internalization", "definition": "Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands. [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798]"}
{"concept_id": "C3271685", "aliases": ["negative regulation of Wnt receptor signaling pathway by Wnt receptor internalization", "negative regulation of Wnt-activated signaling pathway by Wnt receptor internalization", "negative regulation of Wnt receptor signalling pathway by Wnt receptor internalization"], "types": ["T043"], "canonical_name": "negative regulation of Wnt signaling pathway by Wnt receptor internalization", "definition": "Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt signal transduction. [GOC:bf, GOC:BHF, GOC:rl, PMID:17908284, PMID:19643732]"}
{"concept_id": "C3271686", "aliases": [], "types": ["T043"], "canonical_name": "ligand-dependent internalization of Frizzled"}
{"concept_id": "C3271687", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Wnt receptor signaling pathway by Wnt receptor endocytosis"}
{"concept_id": "C3271688", "aliases": ["positive regulation of Wnt receptor signaling pathway by Wnt receptor internalization", "positive regulation of Wnt receptor signalling pathway by Wnt receptor endocytosis"], "types": ["T043"], "canonical_name": "positive regulation of Wnt signaling pathway by Wnt receptor internalization", "definition": "Any process in which internalization of a Wnt receptor activates or increases the frequency, rate or extent of the Wnt signaling pathway. [GOC:bf, GOC:signaling, PMID:17908284]"}
{"concept_id": "C3271689", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt receptor signaling pathway by Frizzled internalization"}
{"concept_id": "C3271690", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt receptor signaling pathway by LRP6 internalization"}
{"concept_id": "C3271691", "aliases": ["negative regulation of insulin receptor signalling pathway by insulin receptor internalization"], "types": ["T043"], "canonical_name": "negative regulation of insulin receptor signaling pathway by insulin receptor internalization", "definition": "Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation. [GOC:bf, GOC:signaling, PMID:18492485, PMID:7821727, PMID:7978876, PMID:9609114]"}
{"concept_id": "C3271692", "aliases": [], "types": ["T043"], "canonical_name": "agonist-stimulated insulin receptor internalization"}
{"concept_id": "C3271693", "aliases": ["positive regulation of insulin receptor signalling pathway by insulin receptor internalization"], "types": ["T044"], "canonical_name": "positive regulation of insulin receptor signaling pathway by insulin receptor internalization", "definition": "Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane. [GOC:bf, GOC:signaling, PMID:9609114]"}
{"concept_id": "C3271694", "aliases": [], "types": ["T067"], "canonical_name": "insulin receptor internalization", "definition": "A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell. [GOC:bf, PMID:3907718, PMID:9609114]"}
{"concept_id": "C3271695", "aliases": [], "types": ["T043"], "canonical_name": "insulin receptor endocytosis"}
{"concept_id": "C3271696", "aliases": [], "types": ["T043"], "canonical_name": "Wnt receptor internalization", "definition": "A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell. [GOC:bf, PMID:17908284]"}
{"concept_id": "C3271697", "aliases": [], "types": ["T043"], "canonical_name": "Wnt receptor endocytosis"}
{"concept_id": "C3271698", "aliases": ["Wnt receptor breakdown", "negative regulation of Wnt receptor signaling pathway by Wnt receptor degradation", "Wnt receptor catabolism"], "types": ["T044"], "canonical_name": "Wnt receptor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. [GOC:BHF, GOC:rl, GOC:signaling, PMID:19643732]"}
{"concept_id": "C3271699", "aliases": [], "types": ["T044"], "canonical_name": "Frizzled degradation"}
{"concept_id": "C3271700", "aliases": [], "types": ["T044"], "canonical_name": "Wnt receptor degradation"}
{"concept_id": "C3271701", "aliases": [], "types": ["T043"], "canonical_name": "Wnt receptor recycling", "definition": "The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. [GOC:bf, GOC:signaling, PMID:19643732]"}
{"concept_id": "C3271702", "aliases": [], "types": ["T043"], "canonical_name": "Frizzled recycling"}
{"concept_id": "C3271703", "aliases": [], "types": ["T043"], "canonical_name": "insulin receptor recycling", "definition": "The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. [GOC:bf, GOC:signaling, PMID:3907718]"}
{"concept_id": "C3271704", "aliases": [], "types": ["T044"], "canonical_name": "leptin receptor activity", "definition": "Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:signaling, PMID:9102398, Wikipedia:Leptin_receptor]"}
{"concept_id": "C3271705", "aliases": ["G-protein coupled olfactory receptor activity", "G-protein coupled odorant receptor activity", "odorant receptor activity, G-protein coupled", "olfactory receptor activity, G-protein coupled"], "types": ["T044"], "canonical_name": "G protein-coupled olfactory receptor activity", "definition": "Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:sart, PMID:21041441]"}
{"concept_id": "C3271707", "aliases": ["signalling receptor activity", "receptor activity involved in signal transduction"], "types": ["T044"], "canonical_name": "signaling receptor activity", "definition": "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]"}
{"concept_id": "C3271708", "aliases": ["receptor activity involved in receptor-mediated endocytosis"], "types": ["T044"], "canonical_name": "cargo receptor activity", "definition": "Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles. [PMID:15239958, PMID:27903609]"}
{"concept_id": "C3271709", "aliases": [], "types": ["T044"], "canonical_name": "endocytic receptor activity"}
{"concept_id": "C3271710", "aliases": [], "types": ["T044"], "canonical_name": "transport receptor activity"}
{"concept_id": "C3271711", "aliases": ["reeler receptor activity"], "types": ["T044"], "canonical_name": "reelin receptor activity", "definition": "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, PMID:12827279, PMID:20223215]"}
{"concept_id": "C3271712", "aliases": ["reelin-mediated signalling pathway", "reeler-mediated signaling pathway", "reelin-mediated signal transduction pathway"], "types": ["T044"], "canonical_name": "reelin-mediated signaling pathway", "definition": "The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, PMID:12827279, PMID:20223215]"}
{"concept_id": "C3271713", "aliases": ["apolipoprotein A-I-mediated signalling pathway"], "types": ["T044"], "canonical_name": "apolipoprotein A-I-mediated signaling pathway", "definition": "The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:signaling, PMID:16443932]"}
{"concept_id": "C3271714", "aliases": ["insulin receptor signalling pathway via phosphatidylinositol 3-kinase cascade", "insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade", "insulin receptor signaling via PI3K", "insulin receptor signaling pathway via PI3K cascade"], "types": ["T044"], "canonical_name": "insulin receptor signaling pathway via phosphatidylinositol 3-kinase", "definition": "An insulin receptor signaling pathway in which the signal is transmitted via the phosphatidylinositol 3-kinase cascade. [GOC:bf, GOC:signaling, PMID:19322168, PMID:20696212]"}
{"concept_id": "C3271715", "aliases": ["EGFR/MAPK signaling", "epidermal growth factor receptor signaling pathway via MAPKKK cascade", "EGFR signaling via MAPKKK cascade", "EGFR signaling pathway via MAPKKK cascade", "epidermal growth factor receptor signalling pathway via MAPKKK cascade"], "types": ["T044"], "canonical_name": "epidermal growth factor receptor signaling pathway via MAPK cascade", "definition": "An epidermal growth factor receptor signaling pathway in which the signal is transmitted via the MAPKKK cascade. [GOC:bf, GOC:signaling, PMID:21167805]"}
{"concept_id": "C3271716", "aliases": ["non-canonical Wnt receptor signaling pathway via MAPK cascade", "non-canonical Wnt receptor signaling pathway via MAPKKK cascade", "non-canonical Wnt-activated signaling pathway via MAPK cascade", "non-canonical Wnt receptor signalling pathway via MAPKKK cascade", "non-canonical Wnt receptor signaling pathway via MAPK signaling"], "types": ["T044"], "canonical_name": "non-canonical Wnt signaling pathway via MAPK cascade", "definition": "The series of molecular signals initiated by a Wnt protein binding to a frizzled family receptor on the surface of a target cell, where the signal is passed on via the MAPKKK cascade. [GOC:BHF, GOC:signaling, GOC:vk, PMID:17720811]"}
{"concept_id": "C3271717", "aliases": ["non-canonical Wnt receptor signalling pathway via JNK cascade", "non-canonical Wnt receptor signaling pathway via JNK cascade", "non-canonical Wnt-activated signaling pathway via JNK cascade"], "types": ["T044"], "canonical_name": "non-canonical Wnt signaling pathway via JNK cascade", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade. [GOC:BHF, GPC:rl, PMID:19137009, PMID:20032469]"}
{"concept_id": "C3271718", "aliases": ["termination of G-protein coupled receptor signaling pathway", "termination of G-protein coupled receptor signalling pathway", "termination of GPCR signaling pathway"], "types": ["T044"], "canonical_name": "termination of G protein-coupled receptor signaling pathway", "definition": "The signaling process in which G protein-coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal. [GOC:bf, GOC:signaling]"}
{"concept_id": "C3271719", "aliases": ["VEGF-VEGFR-induced endothelial cell chemotaxis", "positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway", "positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway", "definition": "The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis. [GOC:bf, GOC:BHF, GOC:rl, PMID:21245381]"}
{"concept_id": "C3271720", "aliases": [], "types": ["T044"], "canonical_name": "vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis"}
{"concept_id": "C3271721", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-mediated chemotactic endothelial cell migration"}
{"concept_id": "C3271722", "aliases": ["signal transduction in absence of agonist"], "types": ["T043"], "canonical_name": "signal transduction in absence of ligand", "definition": "The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. [GOC:al, GOC:ppm, GOC:pr, PMID:15044679]"}
{"concept_id": "C3271723", "aliases": [], "types": ["T043"], "canonical_name": "addiction receptor signaling pathway"}
{"concept_id": "C3271724", "aliases": [], "types": ["T043"], "canonical_name": "basal signaling"}
{"concept_id": "C3271725", "aliases": [], "types": ["T043"], "canonical_name": "negative signal transduction"}
{"concept_id": "C3271726", "aliases": [], "types": ["T043"], "canonical_name": "non-classical signal transduction"}
{"concept_id": "C3271727", "aliases": ["G-protein coupled receptor signaling in absence of agonist", "G-protein coupled receptor signalling in absence of ligand", "G-protein coupled receptor signaling in absence of ligand"], "types": ["T044"], "canonical_name": "G protein-coupled receptor signaling in absence of ligand", "definition": "The series of molecular signals beginning with a consequence of a G protein-coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G protein-coupled receptor is not bound to an agonist. [GOC:al, PMID:12402500, PMID:17629961]"}
{"concept_id": "C3271728", "aliases": [], "types": ["T044"], "canonical_name": "basal G-protein coupled receptor signaling"}
{"concept_id": "C3271729", "aliases": ["S1P receptor activity"], "types": ["T044"], "canonical_name": "sphingosine-1-phosphate receptor activity", "definition": "Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, PMID:12728273, Wikipedia:S1PR1]"}
{"concept_id": "C3271730", "aliases": ["GPCR dimer", "G-protein coupled receptor dimeric complex location", "G-protein coupled receptor dimer", "G protein-coupled receptor dimeric complex location", "G-protein coupled receptor dimeric complex"], "types": ["T026"], "canonical_name": "G protein-coupled receptor dimeric complex", "definition": "A protein complex that contains two G protein-coupled receptors. [GOC:al, GOC:bf, PMID:10713101]"}
{"concept_id": "C3271731", "aliases": ["G protein-coupled receptor homodimeric complex location", "G-protein coupled receptor homodimer", "GPCR homodimer", "G-protein coupled receptor homodimeric complex location", "G-protein coupled receptor homodimeric complex"], "types": ["T026"], "canonical_name": "G protein-coupled receptor homodimeric complex", "definition": "A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor. [GOC:al, GOC:bf, PMID:10713101, PMID:16670762]"}
{"concept_id": "C3271732", "aliases": ["G-protein coupled receptor heterodimeric complex location", "G-protein coupled receptor heterodimeric complex", "G protein-coupled receptor heterodimeric complex location", "G-protein coupled receptor heterodimer", "GPCR heterodimer"], "types": ["T026"], "canonical_name": "G protein-coupled receptor heterodimeric complex", "definition": "A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR. [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]"}
{"concept_id": "C3271734", "aliases": ["cross-receptor inhibition within G-protein coupled receptor heterodimer"], "types": ["T039"], "canonical_name": "cross-receptor inhibition within G protein-coupled receptor heterodimer", "definition": "Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit. [GOC:al, GOC:bf, PMID:15979374]"}
{"concept_id": "C3271735", "aliases": ["dimeric G-protein coupled receptor signaling pathway", "dimeric G-protein coupled receptor signalling pathway"], "types": ["T044"], "canonical_name": "G-protein coupled receptor signaling pathway via GPCR dimer"}
{"concept_id": "C3271736", "aliases": ["interleukin-5-mediated signalling pathway", "IL-5-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-5-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]"}
{"concept_id": "C3271738", "aliases": ["large latent complex location", "large latent transforming growth factor-beta complex location", "LLC", "large latent complex"], "types": ["T026"], "canonical_name": "large latent transforming growth factor-beta complex", "definition": "A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors. [GOC:bf, PMID:2350783, PMID:8680476, PMID:9805445, Reactome:R-HSA-177107]"}
{"concept_id": "C3271739", "aliases": [], "types": ["T044"], "canonical_name": "enkephalin receptor activity"}
{"concept_id": "C3271740", "aliases": [], "types": ["T044"], "canonical_name": "morphine receptor activity", "definition": "Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf]"}
{"concept_id": "C3271741", "aliases": [], "types": ["T044"], "canonical_name": "dynorphin receptor activity", "definition": "Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin. [GOC:bf, Wikipedia:Dynorphin]"}
{"concept_id": "C3271744", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding"}
{"concept_id": "C3271746", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding"}
{"concept_id": "C3271747", "aliases": [], "types": ["T044"], "canonical_name": "estrogen nuclear receptor activity"}
{"concept_id": "C3271749", "aliases": ["G-protein coupled estrogen receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled estrogen receptor activity", "definition": "Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:signaling, PMID:17379646, PMID:20960099]"}
{"concept_id": "C3271750", "aliases": ["BMP protein secretion", "bone morphogenetic protein secretion"], "types": ["T043"], "canonical_name": "BMP secretion", "definition": "The controlled release of a member of the BMP family of proteins from a cell. [GOC:sart]"}
{"concept_id": "C3271751", "aliases": ["negative regulation of BMP signalling pathway by negative regulation of BMP secretion", "negative regulation of BMP signaling pathway by negative regulation of bone morphogenetic protein secretion"], "types": ["T043"], "canonical_name": "negative regulation of BMP signaling pathway by negative regulation of BMP secretion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell. [GOC:bf, GOC:sart, PMID:21750037]"}
{"concept_id": "C3271752", "aliases": ["receptor activator of nuclear factor kappa-B ligand binding", "CD254 binding", "TNF-related activation-induced cytokine binding", "OPGL binding", "osteoclast differentiation factor binding", "TRANCE binding", "tumor necrosis factor superfamily member 11 binding", "tumor necrosis factor (ligand) superfamily member 11 binding", "osteoprotegerin ligand binding", "RANKL binding", "tumor necrosis factor ligand superfamily member 11 binding", "ODF binding"], "types": ["T044"], "canonical_name": "TNFSF11 binding", "definition": "Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family. [GOC:cjm]"}
{"concept_id": "C3271753", "aliases": ["tumor necrosis factor ligand superfamily member 11 receptor activity", "RANKL receptor activity"], "types": ["T044"], "canonical_name": "TNFSF11 receptor activity", "definition": "Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function. [GOC:bf, GOC:cjm]"}
{"concept_id": "C3271754", "aliases": ["IkappaB kinase-alpha homodimer", "IKKalpha homodimeric complex location", "IKKalpha homodimeric complex", "IKKalpha-IKKalpha protein complex location", "IkappaB kinase alpha homodimer", "IKKalpha-IKKalpha protein complex", "IKKalpha-IKKalpha complex location", "IKKalpha homodimer"], "types": ["T026"], "canonical_name": "IKKalpha-IKKalpha complex", "definition": "A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits. [GOC:bf, PMID:18626576, PMID:21173796]"}
{"concept_id": "C3271755", "aliases": ["canonical nitric oxide signaling", "classical nitric oxide signaling", "nitric oxide-cGMP-mediated signalling pathway", "NO-cGMP signaling pathway"], "types": ["T044"], "canonical_name": "nitric oxide-cGMP-mediated signaling pathway", "definition": "Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP. [GOC:signaling, PMID:21549190, PMID:22019632]"}
{"concept_id": "C3271756", "aliases": ["NIK/NF-kappaB signal transduction", "NIK/NF-kappaB cascade"], "types": ["T044"], "canonical_name": "NIK/NF-kappaB signaling", "definition": "The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882]"}
{"concept_id": "C3271757", "aliases": ["noncanonical NF-kappaB signaling"], "types": ["T044"], "canonical_name": "non-canonical NF-KB signaling"}
{"concept_id": "C3271758", "aliases": [], "types": ["T044"], "canonical_name": "noncanonical nuclear factor kappaB (NF-kappaB) pathway"}
{"concept_id": "C3271759", "aliases": [], "types": ["T044"], "canonical_name": "p52-dependent NF-kappaB signaling"}
{"concept_id": "C3271760", "aliases": ["collagen RTK activity"], "types": ["T044"], "canonical_name": "protein tyrosine kinase collagen receptor activity", "definition": "Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [GOC:bf, GOC:uh, PMID:16626936, PMID:21568710]"}
{"concept_id": "C3271761", "aliases": ["collagen-activated RTK signaling pathway", "collagen-activated tyrosine kinase receptor signalling pathway"], "types": ["T044"], "canonical_name": "collagen-activated tyrosine kinase receptor signaling pathway", "definition": "The series of molecular signals initiated by collagen binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:uh, PMID:15888913, PMID:16626936]"}
{"concept_id": "C3271762", "aliases": [], "types": ["T044"], "canonical_name": "DDR signaling pathway"}
{"concept_id": "C3271763", "aliases": [], "types": ["T044"], "canonical_name": "discoidin domain receptor signaling pathway"}
{"concept_id": "C3271764", "aliases": ["transmembrane collagen receptor activity"], "types": ["T044"], "canonical_name": "collagen receptor activity", "definition": "Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:uh, PMID:21568710]"}
{"concept_id": "C3271765", "aliases": ["collagen-activated signalling pathway"], "types": ["T044"], "canonical_name": "collagen-activated signaling pathway", "definition": "The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:uh, PMID:21568710]"}
{"concept_id": "C3271785", "aliases": ["tyrosine autophosphorylation"], "types": ["T044"], "canonical_name": "peptidyl-tyrosine autophosphorylation", "definition": "The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. [PMID:10037737, PMID:10068444, PMID:10940390]"}
{"concept_id": "C3271786", "aliases": [], "types": ["T044"], "canonical_name": "receptor tyrosine kinase autophosphorylation"}
{"concept_id": "C3271787", "aliases": [], "types": ["T044"], "canonical_name": "RTK autophosphorylation"}
{"concept_id": "C3271788", "aliases": ["VEGF signaling", "VEGF-activated signaling pathway", "vascular endothelial growth factor signalling pathway"], "types": ["T044"], "canonical_name": "vascular endothelial growth factor signaling pathway", "definition": "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:17470632]"}
{"concept_id": "C3271789", "aliases": ["VEGF binding"], "types": ["T044"], "canonical_name": "vascular endothelial growth factor binding", "definition": "Binding to a vascular endothelial growth factor. [PMID:17470632]"}
{"concept_id": "C3271790", "aliases": ["VEGF-activated platelet-derived growth factor receptor signalling pathway", "vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway", "VEGF-A/PDGFR signaling", "VEGF-activated PDGFR signalling pathway", "VEGF/PDGFR signaling pathway"], "types": ["T044"], "canonical_name": "VEGF-activated platelet-derived growth factor receptor signaling pathway", "definition": "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:17470632]"}
{"concept_id": "C3271791", "aliases": ["VEGF-A/PDGFRalpha signaling", "VEGF-activated PDGFRalpha signalling pathway", "VEGF/PDGFRalpha signaling pathway", "vascular endothelial growth factor-activated platelet-derived growth factor receptor-alpha signaling pathway", "VEGF-activated platelet-derived growth factor receptor-alpha signalling pathway"], "types": ["T044"], "canonical_name": "VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway", "definition": "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:17470632]"}
{"concept_id": "C3271792", "aliases": ["VEGF-activated PDGFRbeta signalling pathway", "VEGF-A/PDGFRbeta signaling", "VEGF/PDGFRbeta signaling pathway", "VEGF-activated platelet-derived growth factor receptor-beta signalling pathway", "vascular endothelial growth factor-activated platelet-derived growth factor receptor-beta signaling pathway"], "types": ["T044"], "canonical_name": "VEGF-activated platelet-derived growth factor receptor-beta signaling pathway", "definition": "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:17470632]"}
{"concept_id": "C3271793", "aliases": ["positive regulation of cell migration by vascular endothelial growth factor signalling pathway", "VEGF-induced cell migration", "positive regulation of cell migration by VEGF signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "definition": "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another. [GOC:bf, GOC:signaling]"}
{"concept_id": "C3271794", "aliases": [], "types": ["T043"], "canonical_name": "VEGF-A-induced cell migration"}
{"concept_id": "C3271795", "aliases": ["VEGF/PDGFR-induced cell migration", "positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signalling pathway", "positive regulation of cell migration by VEGF/PDGFR signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway", "definition": "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another. [GOC:bf, GOC:signaling, PMID:17470632]"}
{"concept_id": "C3271796", "aliases": ["positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signalling pathway", "positive regulation of cell proliferation by VEGF/PDGFR signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway", "definition": "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation. [GOC:signaling, PMID:17470632]"}
{"concept_id": "C3271797", "aliases": [], "types": ["T043"], "canonical_name": "VEGF-A-induced cell proliferation"}
{"concept_id": "C3271798", "aliases": ["nodal signalling pathway", "nodal signaling"], "types": ["T044"], "canonical_name": "nodal signaling pathway", "definition": "The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:vk, PMID:17287255]"}
{"concept_id": "C3271799", "aliases": ["Fc receptor signalling pathway"], "types": ["T044"], "canonical_name": "Fc receptor signaling pathway", "definition": "The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:phg, Wikipedia:Fc_receptor]"}
{"concept_id": "C3271800", "aliases": ["Fc-gamma receptor signalling pathway"], "types": ["T044"], "canonical_name": "Fc-gamma receptor signaling pathway", "definition": "The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:phg, PMID:11244038]"}
{"concept_id": "C3271801", "aliases": ["Fc-epsilon receptor signalling pathway"], "types": ["T044"], "canonical_name": "Fc-epsilon receptor signaling pathway", "definition": "The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:phg, PMID:12413516, PMID:15048725]"}
{"concept_id": "C3271802", "aliases": ["Fcgamma receptor-mediated phagocytosis", "Fc-gamma receptor signalling pathway involved in phagocytosis", "IgG-mediated phagocytosis", "Fc gamma receptor-dependent phagocytosis"], "types": ["T044"], "canonical_name": "Fc-gamma receptor signaling pathway involved in phagocytosis", "definition": "An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. [GOC:phg, PMID:12488490, PMID:15466916]"}
{"concept_id": "C3271803", "aliases": ["positive regulation of mast cell activation by Fc-epsilon receptor signalling pathway", "Fc epsilon RI-dependent mast cell activation", "Fc epsilon RI-mediated mast cell activation"], "types": ["T044"], "canonical_name": "positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway", "definition": "An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. [GOC:phg, PMID:12413516]"}
{"concept_id": "C3271804", "aliases": [], "types": ["T043"], "canonical_name": "sequestering of BMP from receptor via BMP binding", "definition": "Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor. [GOC:bf, GOC:signaling, PMID:19855014]"}
{"concept_id": "C3271805", "aliases": [], "types": ["T043"], "canonical_name": "extracellular sequestering of BMP"}
{"concept_id": "C3271806", "aliases": [], "types": ["T043"], "canonical_name": "extracellular sequestering of bone morphogenetic protein"}
{"concept_id": "C3271807", "aliases": ["ActRIIB.ALK4.EGF-CFC complex formation", "nodal receptor complex formation"], "types": ["T044"], "canonical_name": "nodal receptor complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals). [GOC:bf, GOC:signaling, PMID:15062104]"}
{"concept_id": "C3271808", "aliases": [], "types": ["T044"], "canonical_name": "nodal binding", "definition": "Binding to a nodal protein, a member of the transforming growth factor-beta superfamily. [GOC:bf, PMID:20629020]"}
{"concept_id": "C3271809", "aliases": ["binding to and sequestering nodal"], "types": ["T044"], "canonical_name": "sequestering of nodal from receptor via nodal binding", "definition": "Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor. [GOC:signaling, PMID:14570583, PMID:15062104]"}
{"concept_id": "C3271810", "aliases": [], "types": ["T044"], "canonical_name": "extracellular regulation of nodal"}
{"concept_id": "C3271811", "aliases": ["nodal antagonist activity", "activin receptor antagonist activity involved in negative regulation of nodal signalling pathway"], "types": ["T044"], "canonical_name": "activin receptor antagonist activity involved in negative regulation of nodal signaling pathway", "definition": "Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor. [GOC:signaling, PMID:15062104]"}
{"concept_id": "C3271812", "aliases": [], "types": ["T044"], "canonical_name": "activin receptor antagonist activity", "definition": "Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor. [GOC:signaling, PMID:15062104]"}
{"concept_id": "C3271813", "aliases": ["nodal receptor complex location"], "types": ["T026"], "canonical_name": "nodal receptor complex", "definition": "A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell. [GOC:bf, GOC:signaling, PMID:11024047, PMID:15062104]"}
{"concept_id": "C3271814", "aliases": ["ActRIIB.ALK4.EGF-CFC complex location"], "types": ["T026"], "canonical_name": "ActRIIB.ALK4.EGF-CFC complex"}
{"concept_id": "C3271815", "aliases": [], "types": ["T044"], "canonical_name": "sequestering of TGFbeta from receptor via TGFbeta binding", "definition": "Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor. [GOC:bf, GOC:signaling, PMID:19855014]"}
{"concept_id": "C3271816", "aliases": [], "types": ["T044"], "canonical_name": "extracellular sequestering of TGFbeta"}
{"concept_id": "C3271817", "aliases": [], "types": ["T044"], "canonical_name": "extracellular sequestering of transforming growth factor-beta"}
{"concept_id": "C3271818", "aliases": ["chorionic gonadotropin binding", "chorionic gonadotrophin binding"], "types": ["T044"], "canonical_name": "choriogonadotropin hormone binding", "definition": "Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit. [GOC:BHF, GOC:rl, Wikipedia:Human_chorionic_gonadotropin]"}
{"concept_id": "C3271819", "aliases": ["nodal signalling pathway involved in determination of left/right asymmetry", "regulation of transcription from RNA polymerase II promoter by nodal signaling pathway, involved in determination of left/right symmetry"], "types": ["T044"], "canonical_name": "nodal signaling pathway involved in determination of left/right asymmetry", "definition": "The series of molecular signals initiated by a nodal protein binding of to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves. [GOC:BHF, GOC:vk, PMID:12857784, PMID:17287255, PMID:20413706]"}
{"concept_id": "C3271820", "aliases": ["inhibition of appetite by leptin signaling", "reduction of appetite by leptin-mediated signaling", "negative regulation of appetite by leptin-mediated signalling pathway", "suppression of appetite by leptin-mediated signaling pathway"], "types": ["T040"], "canonical_name": "negative regulation of appetite by leptin-mediated signaling pathway", "definition": "The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food. [GOC:BHF, GOC:vk, PMID:19150989]"}
{"concept_id": "C3271821", "aliases": ["interleukin-2-mediated signalling pathway", "IL-2-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-2-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3271822", "aliases": ["interleukin-7-mediated signalling pathway", "IL-7-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-7-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-7 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3271823", "aliases": ["interleukin-8-mediated signalling pathway", "IL-8-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-8-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-8 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3271824", "aliases": ["interleukin-9-mediated signalling pathway", "IL-9-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-9-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-9 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3271825", "aliases": ["interleukin-21-mediated signalling pathway", "IL-21-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-21-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-21 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3271826", "aliases": ["chemokine (C-C motif) ligand 19 signalling pathway", "CCL19-mediated signaling pathway"], "types": ["T043"], "canonical_name": "chemokine (C-C motif) ligand 19 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:15059845]"}
{"concept_id": "C3271827", "aliases": ["C-C chemokine receptor type 7 signaling pathway"], "types": ["T043"], "canonical_name": "C-C chemokine receptor type 7 signaling pathway"}
{"concept_id": "C3271828", "aliases": ["chemokine (C-C motif) ligand 21 signalling pathway", "CCL21-mediated signaling pathway"], "types": ["T043"], "canonical_name": "chemokine (C-C motif) ligand 21 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:15059845]"}
{"concept_id": "C3271829", "aliases": [], "types": ["T044"], "canonical_name": "C-C motif chemokine 19 receptor activity", "definition": "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling, PMID:15059845]"}
{"concept_id": "C3271830", "aliases": [], "types": ["T044"], "canonical_name": "CCL19 receptor activity"}
{"concept_id": "C3271831", "aliases": ["C-C chemokine receptor CCR7 signalling pathway", "CCR7 signaling pathway"], "types": ["T043"], "canonical_name": "C-C chemokine receptor CCR7 signaling pathway", "definition": "The series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:15059845, PMID:15778365]"}
{"concept_id": "C3271832", "aliases": ["CCL19-activated CCR7 signalling pathway"], "types": ["T043"], "canonical_name": "CCL19-activated CCR7 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:15059845]"}
{"concept_id": "C3271833", "aliases": ["CCL21-activated CCR7 signalling pathway"], "types": ["T043"], "canonical_name": "CCL21-activated CCR7 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:15059845]"}
{"concept_id": "C3271834", "aliases": [], "types": ["T044"], "canonical_name": "C-C motif chemokine 21 receptor activity", "definition": "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling, PMID:15059845]"}
{"concept_id": "C3271835", "aliases": [], "types": ["T044"], "canonical_name": "CCL21 receptor activity"}
{"concept_id": "C3271836", "aliases": ["RANTES receptor activity", "CCL5 receptor activity", "small inducible cytokine A5 receptor activity"], "types": ["T044"], "canonical_name": "C-C motif chemokine 5 receptor activity", "definition": "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling]"}
{"concept_id": "C3271837", "aliases": ["TLR2:TLR1 signaling pathway", "toll-like receptor TLR1:TLR2 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor TLR1:TLR2 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding of a heterodimeric TLR1:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:17318230]"}
{"concept_id": "C3271838", "aliases": ["TLR2:TLR6 signaling pathway", "toll-like receptor TLR6:TLR2 signalling pathway"], "types": ["T044"], "canonical_name": "toll-like receptor TLR6:TLR2 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding of a heterodimeric TLR6:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:17318230]"}
{"concept_id": "C3271839", "aliases": [], "types": ["T044"], "canonical_name": "EGFR family signaling pathway"}
{"concept_id": "C3271840", "aliases": ["ERBB3 signalling pathway", "receptor tyrosine-protein kinase erbB-3 signaling pathway", "HER3 signaling pathway"], "types": ["T044"], "canonical_name": "ERBB3 signaling pathway", "definition": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission. [GOC:jc, PMID:16460914, Reactome:R-HSA-1247497]"}
{"concept_id": "C3271841", "aliases": ["NRG receptor activity"], "types": ["T044"], "canonical_name": "neuregulin receptor activity", "definition": "Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:signaling, PMID:16460914, PMID:20672328]"}
{"concept_id": "C3271842", "aliases": [], "types": ["T044"], "canonical_name": "NRG1 receptor activity"}
{"concept_id": "C3271843", "aliases": [], "types": ["T044"], "canonical_name": "NRG2 receptor activity"}
{"concept_id": "C3271844", "aliases": [], "types": ["T044"], "canonical_name": "neuregulin binding", "definition": "Binding to a neuregulin, a member of the EGF family of growth factors. [GOC:bf, GOC:signaling]"}
{"concept_id": "C3271845", "aliases": ["ERBB2-EGFR signalling pathway", "EGFR-HER2 signaling pathway"], "types": ["T044"], "canonical_name": "ERBB2-EGFR signaling pathway", "definition": "The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. [GOC:signaling, PMID:16460914, Reactome:R-HSA-1963589]"}
{"concept_id": "C3271846", "aliases": ["HER2-HER4 signaling pathway", "ERBB2-ERBB4 signalling pathway"], "types": ["T044"], "canonical_name": "ERBB2-ERBB4 signaling pathway", "definition": "The series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4. [GOC:signaling, PMID:16460914, Reactome:R-HSA-1963589]"}
{"concept_id": "C3271847", "aliases": ["HER3-HER4 signaling pathway", "ERBB3-ERBB4 signalling pathway"], "types": ["T044"], "canonical_name": "ERBB3-ERBB4 signaling pathway", "definition": "The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977958]"}
{"concept_id": "C3271848", "aliases": ["ERBB1-ERBB4 signaling pathway", "ERBB4-EGFR signalling pathway", "HER1-HER4 signaling pathway"], "types": ["T044"], "canonical_name": "ERBB4-EGFR signaling pathway", "definition": "The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977959]"}
{"concept_id": "C3271849", "aliases": ["ERBB4 homodimeric signaling pathway", "ERBB4-ERBB4 signalling pathway", "HER4-HER4 signaling pathway"], "types": ["T044"], "canonical_name": "ERBB4-ERBB4 signaling pathway", "definition": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:16460914, Reactome:R-HSA-1250220]"}
{"concept_id": "C3271850", "aliases": ["EGFR-ERBB4 complex location", "EGFR-ERBB4 complex", "ERBB4:EGFR heterodimer", "ERBB4-EGFR complex location"], "types": ["T026"], "canonical_name": "ERBB4-EGFR complex", "definition": "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1). [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977956]"}
{"concept_id": "C3271851", "aliases": ["ERBB3-ERBB4 complex", "ERBB3-ERBB4 complex location", "ERBB4-ERBB3 complex location", "ERBB4:ERBB3 heterodimer"], "types": ["T026"], "canonical_name": "ERBB4-ERBB3 complex", "definition": "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission. [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977955]"}
{"concept_id": "C3271852", "aliases": ["ERBB4-ERBB4 complex location", "ERBB4 homodimer"], "types": ["T026"], "canonical_name": "ERBB4-ERBB4 complex", "definition": "A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4). [GOC:signaling, PMID:16460914, Reactome:R-HSA-1250221]"}
{"concept_id": "C3271853", "aliases": ["EGFR:ERBB2 complex location"], "types": ["T026"], "canonical_name": "EGFR:ERBB2 complex", "definition": "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. [GOC:signaling, PMID:16460914, PMID:1973074, Reactome:R-HSA-1227939, Reactome:R-HSA-1963573, Reactome:R-HSA-1963589]"}
{"concept_id": "C3271854", "aliases": ["EGF:EGFR:ERBB2 complex location"], "types": ["T026"], "canonical_name": "EGF:EGFR:ERBB2 complex"}
{"concept_id": "C3271855", "aliases": ["EGFR:ERBB2 heterodimer"], "types": ["T026"], "canonical_name": "EGFR:ERBB2 heterodimer"}
{"concept_id": "C3271856", "aliases": ["ERBB3:ERBB2 complex location"], "types": ["T026"], "canonical_name": "ERBB3:ERBB2 complex", "definition": "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. [GOC:signaling, PMID:16460914, PMID:8665853, Reactome:R-HSA-1247502, Reactome:R-HSA-1963573, Reactome:R-HSA-1963589]"}
{"concept_id": "C3271857", "aliases": [], "types": ["T026"], "canonical_name": "NRG1/2:ERBB3:ERBB2"}
{"concept_id": "C3271858", "aliases": ["ERBB4:ERBB2 complex location"], "types": ["T026"], "canonical_name": "ERBB4:ERBB2 complex", "definition": "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4. [GOC:signaling, PMID:16460914, PMID:16978839, Reactome:R-HSA-1250224, Reactome:R-HSA-1963573, Reactome:R-HSA-1963589]"}
{"concept_id": "C3271859", "aliases": [], "types": ["T026"], "canonical_name": "ERBB4:ERBB2 heterodimer"}
{"concept_id": "C3271860", "aliases": [], "types": ["T026"], "canonical_name": "NRGs/EGFLs:ERBB4:ERBB2"}
{"concept_id": "C3271861", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of host interferon signaling pathway by virus"}
{"concept_id": "C3271862", "aliases": [], "types": ["T046"], "canonical_name": "inhibition of host MHC class II molecule presentation by virus"}
{"concept_id": "C3271864", "aliases": ["negative regulation by virus of host interferon receptor activity", "downregulation by virus of host interferon receptor activity", "inhibition by virus of host interferon receptor activity", "inhibition of host interferon receptors by virus", "down-regulation by virus of host interferon receptor activity"], "types": ["T040"], "canonical_name": "suppression by virus of host interferon receptor activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor. [GOC:bf, GOC:sp, UniProtKB-KW:KW-1091, VZ:843]"}
{"concept_id": "C3271865", "aliases": ["negative regulation by virus of host protein tyrosine kinase activity", "down-regulation by virus of host protein tyrosine kinase activity", "inhibition by virus of host protein tyrosine kinase activity", "downregulation by virus of host protein tyrosine kinase activity"], "types": ["T040"], "canonical_name": "suppression by virus of host protein tyrosine kinase activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity. [GOC:bf, GOC:sp]"}
{"concept_id": "C3271866", "aliases": ["downregulation by virus of host catalytic activity", "negative regulation by virus of host catalytic activity", "down-regulation by virus of host enzyme activity", "inhibition by virus of host catalytic activity"], "types": ["T040"], "canonical_name": "suppression by virus of host catalytic activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. [GOC:bf]"}
{"concept_id": "C3271867", "aliases": ["down-regulation by virus of host JAK-STAT cascade", "downregulation by virus of host JAK-STAT cascade", "negative regulation by virus of host JAK-STAT cascade", "inhibition by virus of host JAK-STAT cascade"], "types": ["T043"], "canonical_name": "suppression by virus of host JAK-STAT cascade", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signal cascade in the host organism. [GOC:bf, GOC:sp]"}
{"concept_id": "C3271868", "aliases": ["suppression by virus of tyrosine phosphorylation of host STAT protein", "viral inhibition of tyrosine phosphorylation of host STAT protein"], "types": ["T040"], "canonical_name": "negative regulation by virus of tyrosine phosphorylation of host STAT protein"}
{"concept_id": "C3271870", "aliases": ["regulation by virus of host catalytic activity", "regulation of host catalytic activity by virus", "modulation of catalytic activity of host by virus"], "types": ["T043"], "canonical_name": "modulation by virus of host catalytic activity", "definition": "The process in which a virus effects a change in host enzyme activity. [GOC:bf, GOC:sp]"}
{"concept_id": "C3271871", "aliases": ["modulation by virus of protein serine/threonine phosphatase activity in host", "regulation by virus of host protein serine/threonine phosphatase activity"], "types": ["T043"], "canonical_name": "modulation by virus of host protein serine/threonine phosphatase activity", "definition": "The process in which a virus effects a change in host protein serine/threonine phosphatase activity. [GOC:bf, GOC:sp]"}
{"concept_id": "C3271872", "aliases": ["down-regulation by virus of host cytokine activity", "downregulation by virus of host cytokine activity", "inhibition by virus of host cytokine activity", "negative regulation by virus of host cytokine activity"], "types": ["T040"], "canonical_name": "suppression by virus of host cytokine activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity. [GOC:bf, GOC:sp]"}
{"concept_id": "C3271873", "aliases": ["regulation by virus of host autophagy"], "types": ["T043"], "canonical_name": "modulation by virus of host autophagy", "definition": "Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host. [GOC:bf, GOC:sp]"}
{"concept_id": "C3271874", "aliases": ["activation of host autophagy by virus"], "types": ["T043"], "canonical_name": "induction by virus of host autophagy", "definition": "Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host. [GOC:bf, GOC:sp, UniProtKB-KW:KW-1072, VZ:846]"}
{"concept_id": "C3271875", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by virus of host autophagy"}
{"concept_id": "C3271876", "aliases": ["negative regulation by virus of host autophagy", "inhibition of host autophagy by virus", "inhibition by virus of host autophagy"], "types": ["T043"], "canonical_name": "suppression by virus of host autophagy", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host. [GOC:bf, GOC:sp, UniProtKB-KW:KW-1083, VZ:845]"}
{"concept_id": "C3271877", "aliases": ["suppression of host mRNA nuclear export by virus", "inhibition of host mRNA nuclear export by virus", "negative regulation by virus of host mRNA nuclear export", "inhibition by virus of host mRNA nuclear export"], "types": ["T043"], "canonical_name": "suppression by virus of host mRNA export from nucleus", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism. [GOC:bf, GOC:sp, UniProtKB-KW:KW-1099, VZ:902]"}
{"concept_id": "C3271878", "aliases": ["suppression by virus of host RNA polymerase II activity", "inhibition of host RNA polymerase II activity by virus", "negative regulation by virus of host RNA polymerase II activity", "inhibition of host RNA polymerase II by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host mRNA transcription by directly inhibiting RNA polymerase II activity. [GOC:bf, GOC:sp, PMID:25233083]"}
{"concept_id": "C3271879", "aliases": ["inhibition of host pre-mRNA processing by virus", "inhibition of host mRNA processing by virus", "inhibition by virus of host mRNA processing", "negative regulation by virus of host mRNA processing"], "types": ["T045"], "canonical_name": "suppression by virus of host mRNA processing", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. [GOC:bf, GOC:sp, UniProtKB-KW:KW-1103, VZ:903]"}
{"concept_id": "C3271880", "aliases": ["modulation of host chromatin by virus", "modulation by virus of host chromatin organisation", "regulation by virus of host chromatin organization", "modulation of host chromatin structure by virus"], "types": ["T043"], "canonical_name": "modulation by virus of host chromatin organization", "definition": "Any process in which a virus effects a change in the organization of chromatin in the host. [GOC:bf, GOC:sp, PMID:11483770, PMID:16687403]"}
{"concept_id": "C3271881", "aliases": ["regulation by virus of host apoptosis", "modulation by virus of host apoptosis", "modulation of host cell apoptosis by virus"], "types": ["T043"], "canonical_name": "modulation by virus of host apoptotic process", "definition": "Any process in which a virus modulates the frequency, rate or extent of apoptosis of infected host cells. [GOC:bf, GOC:mtg_apoptosis, GOC:sp, UniProtKB-KW:KW-1119]"}
{"concept_id": "C3271882", "aliases": ["negative regulation by virus of host TRAF-mediated signal transduction", "suppression by virus of host tumor necrosis factor receptor-associated factor signaling", "inhibition of host TRAF-mediated signal transduction by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host TRAF-mediated signal transduction", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of TRAF-mediated signal transduction in the host. [GOC:bf, GOC:sp]"}
{"concept_id": "C3271883", "aliases": ["virus-induced cytoplasmic pattern recognition receptor signaling pathway", "cytoplasmic pattern recognition receptor signalling pathway in response to virus"], "types": ["T044"], "canonical_name": "cytoplasmic pattern recognition receptor signaling pathway in response to virus", "definition": "The series of molecular signals initiated by the binding of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. [GOC:bf, PMID:17328678, PMID:18272355, PMID:19531363]"}
{"concept_id": "C3271884", "aliases": [], "types": ["T044"], "canonical_name": "cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway"}
{"concept_id": "C3271885", "aliases": [], "types": ["T044"], "canonical_name": "RIG-I-like receptor (RLR) signaling pathway"}
{"concept_id": "C3271886", "aliases": [], "types": ["T044"], "canonical_name": "RIG-I/MDA5 signaling pathway"}
{"concept_id": "C3271887", "aliases": [], "types": ["T044"], "canonical_name": "RIG-like helicase signaling pathway"}
{"concept_id": "C3271888", "aliases": [], "types": ["T044"], "canonical_name": "RIG-like receptor signaling pathway"}
{"concept_id": "C3271889", "aliases": [], "types": ["T044"], "canonical_name": "RLH signaling pathway"}
{"concept_id": "C3271890", "aliases": [], "types": ["T044"], "canonical_name": "RLR signaling pathway"}
{"concept_id": "C3271891", "aliases": ["RIG-I signalling pathway", "retinoic acid inducible gene I signaling pathway", "DDX58 signaling pathway"], "types": ["T044"], "canonical_name": "RIG-I signaling pathway", "definition": "The series of molecular signals initiated by the binding of viral RNA to a pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I is a cytoplasmic receptor that detects RNA synthesized during viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. [GOC:bf, PMID:17328678, PMID:19620789, PMID:21435580]"}
{"concept_id": "C3271892", "aliases": ["IFIH1 signaling pathway", "melanoma differentiation-associated gene 5 signaling pathway", "MDA-5 signalling pathway"], "types": ["T044"], "canonical_name": "MDA-5 signaling pathway", "definition": "The series of molecular signals initiated by viral RNA binding of a cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 is a cytoplasmic receptor that detects RNA synthesized during viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. [GOC:bf, PMID:19620789]"}
{"concept_id": "C3271893", "aliases": [], "types": ["T044"], "canonical_name": "MDA5 signaling pathway"}
{"concept_id": "C3271894", "aliases": ["regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway in response to a virus. [GOC:bf, GOC:jl]"}
{"concept_id": "C3271895", "aliases": [], "types": ["T044"], "canonical_name": "regulation of MAV signaling"}
{"concept_id": "C3271896", "aliases": ["negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus", "negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway in response to a virus. [GOC:bf, GOC:jl]"}
{"concept_id": "C3271897", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of MAVS signaling"}
{"concept_id": "C3271898", "aliases": ["regulation of IFIH1 signaling pathway", "regulation of MDA-5 signalling pathway", "regulation of MDA5 signaling pathway", "regulation of melanoma differentiation-associated gene 5 signaling pathway"], "types": ["T044"], "canonical_name": "regulation of MDA-5 signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. [GOC:bf, GOC:jl]"}
{"concept_id": "C3271899", "aliases": ["negative regulation of MDA-5 signalling pathway", "negative regulation of melanoma differentiation-associated gene 5 signaling pathway", "negative regulation of IFIH1 signaling pathway", "negative regulation of MDA5 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of MDA-5 signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of the MDA-5 signaling pathway. [GOC:bf, GOC:jl]"}
{"concept_id": "C3271900", "aliases": ["regulation of RIG-I signalling pathway", "regulation of DDX58 signaling pathway", "regulation of retinoic acid inducible gene I signaling pathway"], "types": ["T044"], "canonical_name": "regulation of RIG-I signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the RIG-I signaling pathway. [GOC:bf, GOC:jl]"}
{"concept_id": "C3271901", "aliases": ["negative regulation of RIG-I signalling pathway", "negative regulation of DDX58 signaling pathway", "negative regulation of retinoic acid inducible gene I signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of RIG-I signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the RIG-I signaling pathway. [GOC:bf, GOC:jl]"}
{"concept_id": "C3271902", "aliases": ["suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus", "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway"], "types": ["T038"], "canonical_name": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the host viral-induced cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response. [GOC:bf, GOC:jl]"}
{"concept_id": "C3271903", "aliases": [], "types": ["T046"], "canonical_name": "suppression by virus of host RIG-I-like receptor (RLR) signaling pathway"}
{"concept_id": "C3271904", "aliases": [], "types": ["T046"], "canonical_name": "suppression by virus of host RIG-I/MDA5 signaling pathway"}
{"concept_id": "C3271905", "aliases": [], "types": ["T046"], "canonical_name": "suppression by virus of host RIG-like helicase signaling pathway"}
{"concept_id": "C3271906", "aliases": [], "types": ["T046"], "canonical_name": "suppression by virus of host RIG-like receptor signaling pathway"}
{"concept_id": "C3271907", "aliases": [], "types": ["T046"], "canonical_name": "suppression by virus of host RLR signaling pathway"}
{"concept_id": "C3271910", "aliases": ["inhibition by virus of host DDX58 activity", "suppression by virus of host RIG-I activity", "inhibition by virus of host RIG-I", "inhibition of host DDX58/RIG-I by virus", "suppression by virus of host RIG-I signaling pathway", "suppression by virus of host RIG-I signalling pathway"], "types": ["T040"], "canonical_name": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity", "definition": "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. [PMID:19454348, PMID:26138103]"}
{"concept_id": "C3271918", "aliases": ["inhibition of host MAVS by virus", "suppression by virus of host mitochondrial antiviral-signaling protein"], "types": ["T040"], "canonical_name": "suppression by virus of host MAVS activity"}
{"concept_id": "C3271920", "aliases": ["inhibition of host TRAFs by virus"], "types": ["T040"], "canonical_name": "suppression by virus of host TRAF activity", "definition": "Any process in which a virus stops, prevents, or reduces the activity of a host TRAF (tumor necrosis factor receptor-associated factor) protein. TRAFs are intracellular signal transducers that lie downstream of receptors including RIG-I, MDA-5 and Toll-like receptors (TLR) and transfer the signal to other intracellular signaling components. [GOC:bf, UniProtKB-KW:KW-1110, VZ:715]"}
{"concept_id": "C3271921", "aliases": ["suppression by virus of host interferon regulatory factor 3", "inhibition of host IRF3 by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host IRF3 activity"}
{"concept_id": "C3271922", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of IRF3-dependent antiviral response"}
{"concept_id": "C3271928", "aliases": ["DDX58 binding", "DDX58/RIG-I binding"], "types": ["T044"], "canonical_name": "RIG-I binding", "definition": "Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA. [GOC:bf, PMID:21233210]"}
{"concept_id": "C3271929", "aliases": ["down-regulation by virus of host chemokine activity", "downregulation by virus of host chemokine activity", "negative regulation by virus of host chemokine activity", "inhibition of host chemokines by virus", "inhibition by virus of host chemokine activity"], "types": ["T040"], "canonical_name": "suppression by virus of host chemokine activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity. [GOC:bf, GOC:sp, UniProtKB-KW:KW-1086, VZ:813]"}
{"concept_id": "C3271930", "aliases": [], "types": ["T026"], "canonical_name": "Odland body"}
{"concept_id": "C3271931", "aliases": ["Wnt-activated receptor activity"], "types": ["T044"], "canonical_name": "Wnt receptor activity", "definition": "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:go_curators]"}
{"concept_id": "C3271932", "aliases": [], "types": ["T044"], "canonical_name": "pyridoxine-5'-phosphate biosynthesis"}
{"concept_id": "C3271933", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "definition": "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]"}
{"concept_id": "C3271934", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type endopeptidase regulator activity involved in apoptotic process", "definition": "Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]"}
{"concept_id": "C3271935", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of caspase activity"}
{"concept_id": "C3271936", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cysteine-type endopeptidase activity involved in apoptotic process", "definition": "Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis. [GOC:jl, GOC:mtg_apoptosis]"}
{"concept_id": "C3271938", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of MAPK cascade"}
{"concept_id": "C3271939", "aliases": [], "types": ["T044"], "canonical_name": "activation of MAPK cascade"}
{"concept_id": "C3271940", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of neuron apoptosis"}
{"concept_id": "C3271941", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sugar utilization"}
{"concept_id": "C3271942", "aliases": [], "types": ["T045"], "canonical_name": "DNA-3-methyladenine glycosylase III"}
{"concept_id": "C3271944", "aliases": [], "types": ["T044"], "canonical_name": "ossification involved in bone modeling"}
{"concept_id": "C3271945", "aliases": ["fully spanning plasma membrane"], "types": ["T024"], "canonical_name": "spanning component of plasma membrane", "definition": "The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane. [GOC:ecd]"}
{"concept_id": "C3271946", "aliases": [], "types": ["T044"], "canonical_name": "dermal ossification"}
{"concept_id": "C3271947", "aliases": ["cell wall polysaccharide breakdown"], "types": ["T043"], "canonical_name": "cell wall polysaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cell wall polysaccharides. [GOC:mengo_curators]"}
{"concept_id": "C3271948", "aliases": ["plant-type cell wall polysaccharide breakdown"], "types": ["T044"], "canonical_name": "plant-type cell wall cellulose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, which forms part of the cell wall. [GOC:mengo_curators]"}
{"concept_id": "C3271949", "aliases": [], "types": ["T045"], "canonical_name": "DNA excision", "definition": "The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised. [GOC:jl]"}
{"concept_id": "C3271950", "aliases": [], "types": ["T043"], "canonical_name": "micropinocytosis", "definition": "An endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm. [PMID:14731589, PMID:14732047]"}
{"concept_id": "C3271951", "aliases": [], "types": ["T043"], "canonical_name": "macropinocytosis", "definition": "An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. [PMID:14732047]"}
{"concept_id": "C3271952", "aliases": ["pinocytic vesicle"], "types": ["T026"], "canonical_name": "pinosome", "definition": "A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis. [PMID:14731589, PMID:14732047]"}
{"concept_id": "C3271953", "aliases": [], "types": ["T026"], "canonical_name": "micropinosome", "definition": "A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis. [PMID:14731589, PMID:14732047]"}
{"concept_id": "C3271954", "aliases": [], "types": ["T026"], "canonical_name": "macropinosome", "definition": "A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis. [PMID:14732047]"}
{"concept_id": "C3271955", "aliases": [], "types": ["T043"], "canonical_name": "clearance of foreign intracellular DNA", "definition": "A defense process that protects an organism from invading foreign DNA. [GO:jl, PMID:20062055]"}
{"concept_id": "C3271956", "aliases": [], "types": ["T043"], "canonical_name": "clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine"}
{"concept_id": "C3271957", "aliases": ["regulation of ribosomal RNA stability"], "types": ["T045"], "canonical_name": "regulation of rRNA stability", "definition": "Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs. [GOC:jl]"}
{"concept_id": "C3271958", "aliases": ["envenomation resulting in hemorrhagic damage to other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in hemorrhagic damage in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism. [PMID:10441379, PMID:20614020]"}
{"concept_id": "C3271959", "aliases": ["modulation of molecular function in other organism"], "types": ["T040"], "canonical_name": "modulation of molecular function in another organism", "definition": "The process in which an organism effects a change in the function of proteins in a second organism. [GOC:jl]"}
{"concept_id": "C3271960", "aliases": ["modulation of voltage-gated potassium channel activity in other organism"], "types": ["T038"], "canonical_name": "modulation of voltage-gated potassium channel activity in another organism", "definition": "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism. [GOC:jl]"}
{"concept_id": "C3271961", "aliases": ["negative regulation of voltage-gated potassium channel activity in other organism"], "types": ["T044"], "canonical_name": "negative regulation of voltage-gated potassium channel activity in another organism", "definition": "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism. [GOC:jl]"}
{"concept_id": "C3271962", "aliases": ["negative regulation of molecular function in other organism"], "types": ["T044"], "canonical_name": "negative regulation of molecular function in another organism", "definition": "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism. [GOC:jl]"}
{"concept_id": "C3271963", "aliases": ["modulation of potassium channel activity in other organism"], "types": ["T038"], "canonical_name": "modulation of potassium channel activity in another organism", "definition": "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a potassium channel in another organism. [GOC:jl]"}
{"concept_id": "C3271964", "aliases": ["disruption of cells of other organism"], "types": ["T040"], "canonical_name": "disruption of cells of another organism", "definition": "A process in which an organism has a negative effect on the functioning of the second organism's cells. [GOC:jl]"}
{"concept_id": "C3271965", "aliases": ["envenomation resulting in regulation of platelet aggregation in other organism", "envenomation resulting in modulation of platelet aggregation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of platelet aggregation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3271966", "aliases": [], "types": ["T040"], "canonical_name": "feeding on or from other organism"}
{"concept_id": "C3271967", "aliases": [], "types": ["T040"], "canonical_name": "feeding from tissue of other organism"}
{"concept_id": "C3271968", "aliases": [], "types": ["T040"], "canonical_name": "feeding from vascular tissue of another organism"}
{"concept_id": "C3271969", "aliases": [], "types": ["T038"], "canonical_name": "injection of substance into other organism during feeding on blood of other organism"}
{"concept_id": "C3271970", "aliases": [], "types": ["T038"], "canonical_name": "feeding from phloem of other organism"}
{"concept_id": "C3271971", "aliases": [], "types": ["T038"], "canonical_name": "feeding from xylem of other organism"}
{"concept_id": "C3271972", "aliases": [], "types": ["T044"], "canonical_name": "cytokinin binding", "definition": "Binding to a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators. [GOC:jl]"}
{"concept_id": "C3271973", "aliases": ["DNA bending involving sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "sequence-specific DNA binding, bending", "definition": "The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. [GOC:jl, GOC:vw]"}
{"concept_id": "C3271974", "aliases": [], "types": ["T043"], "canonical_name": "regulation of peroxisome size", "definition": "Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. [GOC:jl]"}
{"concept_id": "C3271976", "aliases": ["RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending", "RNA polymerase II proximal promoter region sequence-specific DNA binding, bending", "RNA polymerase II promoter proximal region sequence-specific DNA binding, bending"], "types": ["T045"], "canonical_name": "RNA polymerase II proximal promoter sequence-specific DNA binding, bending"}
{"concept_id": "C3271977", "aliases": ["DNA bending involving non-sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "non-sequence-specific DNA binding, bending", "definition": "The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. [GOC:jl, GOC:vw, PMID:20123079]"}
{"concept_id": "C3271978", "aliases": ["protein localisation to actin cortical patch"], "types": ["T043"], "canonical_name": "protein localization to actin cortical patch", "definition": "A process in which a protein is transported to, or maintained in, an actin cortical patch. [GOC:mah, PMID:21620704]"}
{"concept_id": "C3271979", "aliases": ["protein localisation to cytoskeleton"], "types": ["T043"], "canonical_name": "protein localization to cytoskeleton", "definition": "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. [GOC:jl]"}
{"concept_id": "C3271980", "aliases": ["cellular glucose import in response to insulin stimulus"], "types": ["T043"], "canonical_name": "glucose import in response to insulin stimulus", "definition": "The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus. [GOC:BHF, PMID:19079291]"}
{"concept_id": "C3271981", "aliases": ["CLRC ubiquitin ligase complex localisation to heterochromatin", "CLRC ubiquitin ligase complex localization to heterochromatin"], "types": ["T043"], "canonical_name": "CLRC complex localization to heterochromatin", "definition": "The process by which a CLRC complex is transported to, or maintained in, heterochromatin. CLRC complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation. [GOC:jl]"}
{"concept_id": "C3271982", "aliases": [], "types": ["T026"], "canonical_name": "host chromosome", "definition": "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell. [GOC:jl]"}
{"concept_id": "C3271983", "aliases": ["host outer membrane"], "types": ["T026"], "definition": "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell. [GOC:jl]", "canonical_name": "host cell outer membrane"}
{"concept_id": "C3271984", "aliases": [], "types": ["T026"], "canonical_name": "integral to membrane of host cell", "definition": "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell. [GOC:jl]"}
{"concept_id": "C3271985", "aliases": [], "types": ["T026"], "canonical_name": "integral to host endoplasmic reticulum membrane", "definition": "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell. [GOC:jl]"}
{"concept_id": "C3271986", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein kinase activity by regulation of protein phosphorylation", "definition": "The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase. [GOC:jl]"}
{"concept_id": "C3271987", "aliases": [], "types": ["T044"], "canonical_name": "small protein activating enzyme binding", "definition": "Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme. [GOC:jl]"}
{"concept_id": "C3271988", "aliases": ["small conjugating protein ligase binding", "E3 protein ligase binding"], "types": ["T044"], "canonical_name": "ubiquitin-like protein ligase binding", "definition": "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. [GOC:jl]"}
{"concept_id": "C3271989", "aliases": ["small protein conjugating enzyme binding", "E2 protein ligase binding"], "types": ["T044"], "canonical_name": "ubiquitin-like protein conjugating enzyme binding", "definition": "Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. [GOC:jl]"}
{"concept_id": "C3271990", "aliases": ["lysine malonylation"], "types": ["T044"], "canonical_name": "peptidyl-lysine malonylation", "definition": "The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine. [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568]"}
{"concept_id": "C3271991", "aliases": [], "types": ["T026"], "canonical_name": "microspike", "definition": "A dynamic, actin-rich projection extending from the surface of a migrating animal cell. [PMID:11429692, PMID:12153987, PMID:19095735]"}
{"concept_id": "C3271992", "aliases": [], "types": ["T044"], "canonical_name": "protein malonylation", "definition": "The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group. [GOC:sp]"}
{"concept_id": "C3271993", "aliases": [], "types": ["T044"], "canonical_name": "protein targeting to vacuolar membrane", "definition": "The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein. [GOC:jl]"}
{"concept_id": "C3271994", "aliases": ["actin cortical patch organisation"], "types": ["T043"], "canonical_name": "actin cortical patch organization", "definition": "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis. [GOC:jl]"}
{"concept_id": "C3271996", "aliases": ["envenomation resulting in induction of oedema in other organism", "envenomation resulting in induction of edema in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in induction of edema in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the swelling of soft tissues of the bitten organism as a result of excess water accumulation. [GOC:jl, PMID:20562011]"}
{"concept_id": "C3271997", "aliases": [], "types": ["T043"], "canonical_name": "motile cilium assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a motile cilium. [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]"}
{"concept_id": "C3271998", "aliases": ["regulation of sensory perception of pain in another organism", "modulation of sensory perception of pain in other organism"], "types": ["T040"], "canonical_name": "modulation of sensory perception of pain in another organism", "definition": "A process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal, in a different organism. [GOC:ed, PMID:18579526]"}
{"concept_id": "C3271999", "aliases": ["glutaryl-CoA thioesterase activity"], "types": ["T044"], "canonical_name": "glutaryl-CoA hydrolase activity", "definition": "Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate. [GOC:pm, PMID:16141203]"}
{"concept_id": "C3272000", "aliases": [], "types": ["T043"], "canonical_name": "glial cell-derived neurotrophic factor secretion"}
{"concept_id": "C3272001", "aliases": ["envenomation resulting in regulation of blood coagulation in other organism", "envenomation resulting in modulation of blood coagulation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of blood coagulation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism. [GOC:jl]"}
{"concept_id": "C3272002", "aliases": ["envenomation resulting in positive regulation of blood coagulation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of blood coagulation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism. [GOC:jl]"}
{"concept_id": "C3272003", "aliases": ["envenomation resulting in negative regulation of blood coagulation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of blood coagulation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of blood coagulation in the bitten organism. [GOC:jl]"}
{"concept_id": "C3272004", "aliases": ["envenomation resulting in pore formation in membrane of other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in pore formation in membrane of another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the aggregation, arrangement and bonding together of a set of components to form a pore complex in a membrane of the bitten organism. [GOC:fj, GOC:jl, PMID:21549739]"}
{"concept_id": "C3272005", "aliases": ["envenomation resulting in modulation of calcium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of calcium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a calcium channel in the bitten organism. [GOC:fj, GOC:jl, PMID:20920515]"}
{"concept_id": "C3272006", "aliases": ["envenomation resulting in negative regulation of calcium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of calcium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism. [GOC:fj, GOC:jl, PMID:20920515]"}
{"concept_id": "C3272007", "aliases": ["envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of voltage-gated calcium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism. [GOC:fj, GOC:jl, PMID:20920515]"}
{"concept_id": "C3272008", "aliases": ["envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of high voltage-gated calcium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a high voltage-gated calcium channel in the bitten organism. [GOC:fj, GOC:jl, PMID:20920515]"}
{"concept_id": "C3272009", "aliases": ["envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of low voltage-gated calcium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a low voltage-gated calcium channel in the bitten organism. [GOC:fj, GOC:jl, PMID:20920515]"}
{"concept_id": "C3272010", "aliases": ["envenomation resulting in negative regulation of platelet aggregation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of platelet aggregation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272011", "aliases": ["envenomation resulting in positive regulation of platelet aggregation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of platelet aggregation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of platelet aggregation in the bitten organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272012", "aliases": ["envenomation resulting in modulation of mast cell degranulation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of mast cell degranulation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of blood mast cell degranulation in the bitten organism. [GOC:fj, GOC:jl, PMID:21549739]"}
{"concept_id": "C3272013", "aliases": ["envenomation resulting in positive regulation of mast cell degranulation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of mast cell degranulation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of blood mast cell degranulation in the bitten organism. [GOC:fj, GOC:jl, PMID:21549739]"}
{"concept_id": "C3272014", "aliases": ["envenomation resulting in proteolysis in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in proteolysis in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism. [GOC:fj, GOC:jl, PMID:15922779]"}
{"concept_id": "C3272015", "aliases": ["envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism", "envenomation resulting in blood vessel ECM, causing hemorrhagic damage in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism. [GOC:fj, GOC:jl, PMID:10441379, PMID:19485419]"}
{"concept_id": "C3272016", "aliases": ["envenomation, impairing hemostasis in other organism", "envenomation resulting in impairment of hemostasis in other organism", "envenomation resulting in negative regulation of hemostasis in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in impairment of hemostasis in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the process of hemostasis - the stopping of bleeding or the arrest of the circulation to an organ or part - in the bitten organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272017", "aliases": ["envenomation resulting in fibrinolysis in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in fibrinolysis in another organism", "definition": "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinolysis, a process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, in the bloodstream of the bitten/stung organism. [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404]"}
{"concept_id": "C3272018", "aliases": ["envenomation resulting in fibrinogenolysis in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in fibrinogenolysis in another organism", "definition": "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism. [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404]"}
{"concept_id": "C3272019", "aliases": ["regulation of transmission of nerve impulse in other organism", "modulation of transmission of nerve impulse in other organism", "modulation of conduction of nerve impulse in other organism"], "types": ["T040"], "canonical_name": "modulation of transmission of nerve impulse in another organism", "definition": "The process in which an organism effects a change in the transmission of a nerve impulse in another organism. [GOC:jl]"}
{"concept_id": "C3272020", "aliases": ["envenomation resulting in modulation of conduction of nerve impulse in other organism", "envenomation resulting in modulation of transmission of nerve impulse in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of transmission of nerve impulse in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the transmission of nerve impulses in the bitten organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272021", "aliases": ["modulation of voltage-gated sodium channel activity in other organism"], "types": ["T038"], "canonical_name": "modulation of voltage-gated sodium channel activity in another organism", "definition": "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. [GOC:fj, GOC:jl, PMID:21781281]"}
{"concept_id": "C3272022", "aliases": ["negative regulation of voltage-gated sodium channel activity in other organism"], "types": ["T044"], "canonical_name": "negative regulation of voltage-gated sodium channel activity in another organism", "definition": "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. [GOC:fj, GOC:jl, PMID:21781281]"}
{"concept_id": "C3272023", "aliases": ["positive regulation of voltage-gated sodium channel activity in other organism"], "types": ["T044"], "canonical_name": "positive regulation of voltage-gated sodium channel activity in another organism", "definition": "Any process that activates or increases the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. [GOC:fj, GOC:jl, PMID:21781281]"}
{"concept_id": "C3272024", "aliases": ["positive regulation of molecular function in other organism"], "types": ["T044"], "canonical_name": "positive regulation of molecular function in another organism", "definition": "Any process that activates or increases the frequency, rate or extent of the function of proteins in a second organism. [GOC:jl]"}
{"concept_id": "C3272025", "aliases": ["envenomation resulting in modulation of voltage-gated sodium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of voltage-gated sodium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated sodium channel in the bitten organism. [GOC:fj, GOC:jl, PMID:21781281]"}
{"concept_id": "C3272026", "aliases": ["envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of voltage-gated sodium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated sodium channel in the bitten organism. [GOC:fj, GOC:jl, PMID:21781281]"}
{"concept_id": "C3272027", "aliases": ["envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of voltage-gated sodium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation or increase in the activity of the activity of a voltage-gated sodium channel in the bitten organism. [GOC:fj, GOC:jl, PMID:21781281]"}
{"concept_id": "C3272028", "aliases": ["modulation of blood pressure in other organism", "regulation of blood pressure in other organism"], "types": ["T042"], "canonical_name": "modulation of blood pressure in another organism", "definition": "A process by which one organism modulates the force with which blood travels through the circulatory system of another organism. [GOC:fj, GOC:jl, PMID:19837656]"}
{"concept_id": "C3272029", "aliases": ["negative regulation of blood pressure in other organism"], "types": ["T040"], "canonical_name": "negative regulation of blood pressure in another organism", "definition": "A process by which one organism decreases the force with which blood travels through the circulatory system of another organism. [GOC:fj, GOC:jl, PMID:19837656]"}
{"concept_id": "C3272030", "aliases": ["positive regulation of blood pressure in other organism"], "types": ["T040"], "canonical_name": "positive regulation of blood pressure in another organism", "definition": "A process by which one organism increases the force with which blood travels through the circulatory system of another organism. [GOC:fj, GOC:jl, PMID:19837656]"}
{"concept_id": "C3272031", "aliases": ["envenomation resulting in modulation of blood pressure in other organism", "envenomation resulting in regulation of blood pressure in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of blood pressure in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the force with which blood travels through the circulatory system of the bitten/stung organism. [GOC:fj, GOC:jl, PMID:19837656]"}
{"concept_id": "C3272032", "aliases": ["envenomation resulting in positive regulation of blood pressure in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of blood pressure in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant increase of the force with which blood travels through the circulatory system of the bitten/stung organism. [GOC:fj, GOC:jl, PMID:19837656]"}
{"concept_id": "C3272033", "aliases": ["envenomation resulting in negative regulation of blood pressure in other organism", "hypotensive activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of blood pressure in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant decrease of the force with which blood travels through the circulatory system of the bitten/stung organism. [GOC:fj, GOC:jl, PMID:19837656]"}
{"concept_id": "C3272034", "aliases": ["modulation of signal transduction in other organism"], "types": ["T044"], "canonical_name": "modulation of signal transduction in another organism", "definition": "The process in which an organism effects a change in a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272035", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of signal transduction in other organism"}
{"concept_id": "C3272036", "aliases": ["modulation of G-protein coupled receptor activity in other organism", "modulation of G protein-coupled receptor activity in other organism"], "types": ["T039"], "canonical_name": "modulation of G protein-coupled receptor activity in another organism", "definition": "The process in which an organism effects a change in the activity of a G protein-coupled receptor in a second organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272037", "aliases": ["modulation of receptor activity in other organism"], "types": ["T039"], "canonical_name": "modulation of receptor activity in another organism", "definition": "The process in which an organism effects a change in the activity of a receptor in a second organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272038", "aliases": ["positive regulation of G-protein coupled receptor activity in other organism", "positive regulation of G protein-coupled receptor activity in other organism"], "types": ["T044"], "canonical_name": "positive regulation of G protein-coupled receptor activity in another organism", "definition": "A process that activates or increases the frequency, rate or extent of the activity of a G protein-coupled receptor in a second organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272039", "aliases": ["modulation of glucagon-like peptide receptor 1 activity in other organism", "regulation of glucagon-like peptide receptor activity in other organism"], "types": ["T039"], "canonical_name": "modulation of glucagon-like peptide receptor 1 activity in another organism", "definition": "The process in which an organism effects a change in the activity of a glucagon-like peptide receptor 1 in a second organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272040", "aliases": ["positive regulation of receptor activity in other organism"], "types": ["T044"], "canonical_name": "positive regulation of receptor activity in another organism", "definition": "A process that activates or increases the frequency, rate or extent of the activity of a receptor in a second organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272041", "aliases": [], "types": ["T044"], "canonical_name": "glucagon-like peptide 1 receptor activity", "definition": "Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein. [GOC:jl, PMID:12529935]"}
{"concept_id": "C3272042", "aliases": ["envenomation resulting in modulation of signal transduction in other organismm"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of signal transduction in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of signal transduction in the bitten organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272043", "aliases": ["envenomation resulting in positive regulation of signal transduction in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of signal transduction in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of signal transduction in the bitten organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272044", "aliases": ["envenomation resulting in modulation of receptor activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of receptor activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of receptor activity in of the bitten organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272045", "aliases": ["envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of glucagon-like peptide receptor 1 activity in of the bitten organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272046", "aliases": ["envenomation resulting in modulation of G-protein coupled receptor activity in other organism", "envenomation resulting in modulation of G protein-coupled receptor activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of G protein-coupled receptor activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G protein-coupled receptor activity in of the bitten organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272047", "aliases": ["envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism", "envenomation resulting in positive regulation of G protein-coupled receptor activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of G protein-coupled receptor activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G protein-coupled receptor activity in of the bitten organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272048", "aliases": ["envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of glucagon-like peptide receptor 1 activity in of the bitten organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272049", "aliases": ["positive regulation of glucagon-like peptide receptor 1 activity in other organism"], "types": ["T044"], "canonical_name": "positive regulation of glucagon-like peptide receptor 1 activity in another organism", "definition": "A process that activates or increases the frequency, rate or extent of the activity of a glucagon-like peptide receptor 1 in a second organism. [GOC:fj, GOC:jl, PMID:8405712]"}
{"concept_id": "C3272050", "aliases": ["modulation of vasoactive intestinal polypeptide receptor activity in other organism", "modulation of VIP receptor activity in other organism", "regulation of vasoactive intestinal polypeptide receptor activity in other organism"], "types": ["T039"], "canonical_name": "modulation of vasoactive intestinal polypeptide receptor activity in another organism", "definition": "The process in which an organism effects a change in the activity of a vasoactive intestinal polypeptide receptor in a second organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272051", "aliases": ["positive regulation of VIP receptor activity in other organism", "positive regulation of vasoactive intestinal polypeptide receptor activity in other organism"], "types": ["T044"], "canonical_name": "positive regulation of vasoactive intestinal polypeptide receptor activity in another organism", "definition": "A process that activates or increases the frequency, rate or extent of the activity of a vasoactive intestinal polypeptide receptor in a second organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272052", "aliases": ["envenomation resulting in regulation of VIP receptor activity in other organism", "envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism", "envenomation resulting in regulation of vasoactive intestinal polypeptide receptor activity in other organism", "envenomation resulting in modulation of VIP receptor activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272053", "aliases": ["envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in other organism", "envenomation resulting in positive regulation of VIP receptor activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272054", "aliases": ["envenomation resulting in muscle damage in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in muscle damage in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant muscle damage in the bitten organism. [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]"}
{"concept_id": "C3272055", "aliases": ["envenomation resulting in myocyte killing causing muscle damage in other organism", "envenomation resulting in myocyte killing in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in myocyte killing in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism. [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]"}
{"concept_id": "C3272056", "aliases": ["envenomation resulting in damage of muscle extracellular matrix causing muscle necrosis in other organism", "envenomation resulting in damage of muscle extracellular matrix in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in damage of muscle extracellular matrix in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism. [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]"}
{"concept_id": "C3272057", "aliases": [], "types": ["T044"], "canonical_name": "protein sulfhydration", "definition": "The modification of a protein amino acid by the addition of sulfur. [GOC:jl, GOC:jsg, PMID:19903941, PMID:22169477, PMID:8161529]"}
{"concept_id": "C3272058", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cystine sulfhydration", "definition": "The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide. [GOC:jl, GOC:jsg]"}
{"concept_id": "C3272059", "aliases": [], "types": ["T044"], "canonical_name": "formation of peptidyl-cystine persulfide by sulphur transfer from free cysteine", "definition": "The modification of a peptidyl-cystine residue in a protein by the transfer of a sulfur atom from a free cysteine (in the process converting the free cysteine to alanine) to the peptidyl-cysteine to form peptidyl-cysteine persulfide. [GOC:jl, GOC:jsg]"}
{"concept_id": "C3272060", "aliases": [], "types": ["T044"], "canonical_name": "formation of peptidyl-cystine persulfide by sulphur transfer from H2S", "definition": "The modification of a peptidyl-cystine residue in a protein by the direct addition of H2S, followed by the removal of 2 protons to form peptidyl-cysteine persulfide. [GOC:jl, GOC:jsg]"}
{"concept_id": "C3272061", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mitochondrial mRNA stability", "definition": "Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs. [GOC:al, GOC:jl]"}
{"concept_id": "C3272062", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mitochondrial rRNA stability", "definition": "Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs. [GOC:al, GOC:jl]"}
{"concept_id": "C3272063", "aliases": ["supraspliceosome complex", "supraspliceosome complex location", "supraspliceosomal complex location"], "types": ["T026"], "canonical_name": "supraspliceosomal complex", "definition": "Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing. [GOC:ans, GOC:jl, PMID:19282290]"}
{"concept_id": "C3272065", "aliases": ["modulation of apoptotic process in other organism", "regulation of apoptotic process in other organism"], "types": ["T043"], "canonical_name": "modulation of apoptotic process in another organism", "definition": "A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism. [GOC:jl]"}
{"concept_id": "C3272066", "aliases": ["positive regulation of apoptotic process in other organism"], "types": ["T043"], "canonical_name": "positive regulation of apoptotic process in another organism", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism. [GOC:jl, PMID:17983639]"}
{"concept_id": "C3272067", "aliases": ["envenomation resulting in modulation of apoptotic process in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of apoptotic process in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism. [GOC:fj, GOC:jl, PMID:17983639]"}
{"concept_id": "C3272068", "aliases": ["very long chain fatty-acyl-CoA oxidase activity", "VLC fatty-acyl-CoA oxidase activity", "very-long-chain acyl-CoA oxidase activity"], "types": ["T044"], "canonical_name": "very-long-chain fatty acyl-CoA oxidase activity", "definition": "Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. [PMID:17458872]"}
{"concept_id": "C3272069", "aliases": ["envenomation resulting in negative regulation of circulating fibrinogen in other organism", "envenomation resulting in depletion of circulating fibrinogen in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in depletion of circulating fibrinogen in another organism", "definition": "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with a reduction in the quantity of fibrinogen found in the bloodstream of the bitten/stung organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272070", "aliases": [], "types": ["T043"], "canonical_name": "regulation of circulating fibrinogen levels", "definition": "Any process that modulates the quantity of fibrinogen circulating in the bloodstream. [GOC:jl]"}
{"concept_id": "C3272071", "aliases": [], "types": ["T026"], "canonical_name": "host cell periphery", "definition": "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell. [GOC:jl, PMID:20463076]"}
{"concept_id": "C3272072", "aliases": ["long-chain fatty acid import", "long-chain fatty acid uptake"], "types": ["T043"], "canonical_name": "long-chain fatty acid import into cell", "definition": "The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. [GOC:jl, GOC:pm, PMID:22022213]"}
{"concept_id": "C3272073", "aliases": [], "types": ["T044"], "canonical_name": "L-cystine L-cysteine-lyase (deaminating)", "definition": "Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide. [GOC:jl, RHEA:24927]"}
{"concept_id": "C3272074", "aliases": ["zymogen activation in other organism"], "types": ["T044"], "canonical_name": "zymogen activation in another organism", "definition": "The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272075", "aliases": ["plasminogen activation in other organism"], "types": ["T044"], "canonical_name": "plasminogen activation in another organism", "definition": "The chemical reactions and pathways performed by an organism resulting in the processing of inactive plasminogen to active plasmin in another organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272076", "aliases": ["envenomation resulting in zymogen activation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in zymogen activation in another organism", "definition": "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the proteolytic processing of an inactive enzyme to an active form. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272077", "aliases": ["envenomation resulting in plasminogen activation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in plasminogen activation in another organism", "definition": "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide. [GOC:fj, GOC:jl]"}
{"concept_id": "C3272078", "aliases": ["non-specific lethal complex", "NSL complex location", "non-specific lethal complex location"], "types": ["T026"], "canonical_name": "NSL complex", "definition": "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1. [GOC:lb, PMID:20018852]"}
{"concept_id": "C3272079", "aliases": ["NALP3 inflammasome complex assembly"], "types": ["T044"], "canonical_name": "NLRP3 inflammasome complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell. [GOC:jl, PMID:21048113]"}
{"concept_id": "C3272080", "aliases": [], "types": ["T044"], "canonical_name": "NLRP3 inflammasome activation"}
{"concept_id": "C3272081", "aliases": [], "types": ["T044"], "canonical_name": "DNA topoisomerase binding", "definition": "Binding to a DNA topoisomerase. [GOC:jl]"}
{"concept_id": "C3272082", "aliases": [], "types": ["T044"], "canonical_name": "DNA topoisomerase I binding"}
{"concept_id": "C3272083", "aliases": ["S100 binding"], "types": ["T044"], "canonical_name": "S100 protein binding", "definition": "Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]"}
{"concept_id": "C3272084", "aliases": [], "types": ["T044"], "canonical_name": "GTP cyclohydrolase binding", "definition": "Binding to a GTP cyclohydrolase. [GOC:jl]"}
{"concept_id": "C3272085", "aliases": ["secondary metabolite biosynthesis"], "types": ["T044"], "canonical_name": "secondary metabolite biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. [GOC:jl]"}
{"concept_id": "C3272086", "aliases": ["envenomation resulting in regulation of vasodilation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of vasodilation in other organism"}
{"concept_id": "C3272088", "aliases": ["modulation of biological quality in other organism", "regulation of biological quality in other organism"], "types": ["T040"], "canonical_name": "modulation of biological quality in another organism", "definition": "Any process that modulates the frequency, rate or extent of a biological quality in another organism. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. [GOC:jl]"}
{"concept_id": "C3272089", "aliases": ["regulation of heart rate in other organism", "modulation of heart rate in other organism"], "types": ["T039"], "canonical_name": "modulation of heart rate in another organism", "definition": "Any process that modulates the frequency or rate of heart contraction of another organism. [GOC:jl, PMID:20923766]"}
{"concept_id": "C3272090", "aliases": ["negative regulation of heart rate in other organism"], "types": ["T040"], "canonical_name": "negative regulation of heart rate in another organism", "definition": "Any process that stops, prevents or reduces the frequency of heart contraction of another organism. [GOC:ecd, GOC:jl, PMID:20923766]"}
{"concept_id": "C3272091", "aliases": ["envenomation resulting in negative regulation of heart rate of other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of heart rate in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism. [GOC:ecd, GOC:jl, PMID:20923766]"}
{"concept_id": "C3272094", "aliases": [], "types": ["T043"], "canonical_name": "invertebrate nurse cell apoptosis"}
{"concept_id": "C3272096", "aliases": [], "types": ["T044"], "canonical_name": "metarhodopsin binding"}
{"concept_id": "C3272097", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}
{"concept_id": "C3272098", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}
{"concept_id": "C3272102", "aliases": [], "types": ["T044"], "canonical_name": "phosphoinositide phosphorylation"}
{"concept_id": "C3272103", "aliases": ["polyvinyl alcohol:ferricytochrome-c oxidoreductase activity"], "types": ["T044"], "canonical_name": "polyvinyl alcohol dehydrogenase (cytochrome) activity", "definition": "Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+. [EC:1.1.2.6]"}
{"concept_id": "C3272105", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity"}
{"concept_id": "C3272106", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine deoxyribonucleoside 2'-hydroxylase activity"}
{"concept_id": "C3272107", "aliases": [], "types": ["T044"], "canonical_name": "pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity"}
{"concept_id": "C3272108", "aliases": ["capsorubin synthase activity", "CCS", "violaxanthin-capsorubin isomerase (ketone-forming) activity"], "types": ["T044"], "definition": "Catalysis of the reaction: antheraxanthin = capsanthin. [EC:5.3.99.8]", "canonical_name": "capsanthin synthase activity"}
{"concept_id": "C3272109", "aliases": [], "types": ["T040"], "canonical_name": "hematophagy"}
{"concept_id": "C3272110", "aliases": ["down-regulation of caspase activity", "down regulation of caspase activity", "downregulation of caspase activity", "negative regulation of caspase activation"], "types": ["T044"], "canonical_name": "negative regulation of cysteine-type endopeptidase activity involved in apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis]"}
{"concept_id": "C3272112", "aliases": [], "types": ["T044"], "canonical_name": "activation of tyrosine autophosphorylation"}
{"concept_id": "C3272117", "aliases": ["down-regulation of beta1 adrenoceptor", "downregulation of beta1-adrenergic receptor activity", "negative regulation of beta1 adrenoceptor", "down-regulation of beta1-adrenergic receptor activity", "down regulation of beta1 adrenoceptor", "downregulation of beta1 adrenoceptor", "down regulation of beta1-adrenergic receptor activity", "inhibition of beta1 adrenoceptor", "inhibition of beta1-adrenergic receptor activity"], "types": ["T043"], "canonical_name": "negative regulation of beta1-adrenergic receptor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of beta1-adrenergic receptor activity. [GOC:TermGenie]"}
{"concept_id": "C3272118", "aliases": ["positive regulation of erUPR", "up-regulation of endoplasmic reticulum unfolded protein response", "up regulation of ER unfolded protein response", "upregulation of erUPR", "activation of endoplasmic reticulum unfolded protein response", "up regulation of erUPR", "up-regulation of erUPR", "positive regulation of ER unfolded protein response", "activation of ER unfolded protein response", "activation of erUPR", "up-regulation of ER unfolded protein response", "upregulation of endoplasmic reticulum unfolded protein response", "up regulation of endoplasmic reticulum unfolded protein response", "upregulation of ER unfolded protein response"], "types": ["T044"], "canonical_name": "positive regulation of endoplasmic reticulum unfolded protein response", "definition": "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. [GOC:TermGenie]"}
{"concept_id": "C3272120", "aliases": ["upregulation of glucocorticoid mediated signaling pathway", "up regulation of glucocorticoid mediated signalling", "positive regulation of glucocorticoid mediated signalling", "up-regulation of glucocorticoid mediated signalling", "upregulation of glucocorticoid mediated signalling", "up regulation of glucocorticoid mediated signaling pathway", "up-regulation of glucocorticoid mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of glucocorticoid mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of glucocorticoid mediated signaling pathway. [GOC:TermGenie]"}
{"concept_id": "C3272121", "aliases": ["positive regulation of RIG-I signalling pathway", "positive regulation of DDX58 signaling pathway", "up regulation of retinoic acid inducible gene I signaling pathway", "up-regulation of DDX58 signaling pathway", "up regulation of RIG-I signaling pathway", "up-regulation of RIG-I signaling pathway", "upregulation of retinoic acid inducible gene I signaling pathway", "up-regulation of retinoic acid inducible gene I signaling pathway", "up regulation of DDX58 signaling pathway", "upregulation of RIG-I signaling pathway", "positive regulation of retinoic acid inducible gene I signaling pathway", "upregulation of DDX58 signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of RIG-I signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway. [GOC:TermGenie]"}
{"concept_id": "C3272122", "aliases": ["positive regulation of stem cell factor receptor signaling pathway", "upregulation of stem cell factor receptor signaling pathway", "up regulation of stem cell factor signaling pathway", "activation of Kit signaling pathway", "up-regulation of Kit signaling pathway", "positive regulation of Kit signalling pathway", "up regulation of stem cell factor receptor signaling pathway", "positive regulation of stem cell factor signaling pathway", "upregulation of Kit signaling pathway", "activation of stem cell factor receptor signaling pathway", "up-regulation of stem cell factor receptor signaling pathway", "activation of stem cell factor signaling pathway", "upregulation of stem cell factor signaling pathway", "up regulation of Kit signaling pathway", "up-regulation of stem cell factor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of Kit signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of Kit signaling pathway. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3272123", "aliases": ["positive regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm", "positive regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm", "up-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "positive regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "activation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "up regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "upregulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm", "activation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm", "activation of nodal signaling of determination of left/right asymmetry in lateral mesoderm", "upregulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm", "up regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm", "up-regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm", "upregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "up regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm", "up-regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm"], "types": ["T043"], "canonical_name": "positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "definition": "Any process that activates or increases the frequency, rate or extent of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3272127", "aliases": ["downregulation of oocyte maturation", "down-regulation of oocyte maturation", "down regulation of oocyte maturation"], "types": ["T043"], "canonical_name": "negative regulation of oocyte maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3272128", "aliases": ["down-regulation of phenotypic switching", "downregulation of phenotypic switching", "down regulation of phenotypic switching"], "types": ["T043"], "canonical_name": "negative regulation of phenotypic switching", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phenotypic switching. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3272129", "aliases": ["down-regulation of dosage compensation, by inactivation of X chromosome", "inhibition of X chromosome inactivation", "down-regulation of X chromosome inactivation", "negative regulation of X chromosome inactivation", "downregulation of X chromosome inactivation", "down regulation of X chromosome inactivation", "inhibition of dosage compensation, by inactivation of X chromosome", "down regulation of dosage compensation, by inactivation of X chromosome", "downregulation of dosage compensation, by inactivation of X chromosome"], "types": ["T043"], "canonical_name": "negative regulation of dosage compensation by inactivation of X chromosome", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dosage compensation, by inactivation of X chromosome. [GOC:TermGenie]"}
{"concept_id": "C3272130", "aliases": ["down-regulation of phospholipid scramblase activity", "down regulation of phospholipid scramblase activity", "downregulation of phospholipid scramblase activity"], "types": ["T044"], "canonical_name": "negative regulation of phospholipid scramblase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid scramblase activity. [GOC:TermGenie]"}
{"concept_id": "C3272131", "aliases": ["downregulation of arachidonic acid secretion", "down-regulation of arachidonic acid secretion", "down regulation of arachidonic acid secretion"], "types": ["T043"], "canonical_name": "negative regulation of arachidonic acid secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion. [GOC:TermGenie]"}
{"concept_id": "C3272132", "aliases": ["down-regulation of single-species biofilm formation", "down regulation of single-species biofilm formation", "downregulation of single-species biofilm formation"], "types": ["T043"], "canonical_name": "negative regulation of single-species biofilm formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3272133", "aliases": ["down-regulation of single-species biofilm formation in or on host organism", "downregulation of single-species biofilm formation in or on host organism", "down regulation of single-species biofilm formation in or on host organism"], "types": ["T043"], "canonical_name": "negative regulation of single-species biofilm formation in or on host organism", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3272134", "aliases": ["downregulation of single-species biofilm formation on inanimate substrate", "down-regulation of single-species biofilm formation on inanimate substrate", "down regulation of single-species biofilm formation on inanimate substrate"], "types": ["T043"], "canonical_name": "negative regulation of single-species biofilm formation on inanimate substrate", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3272135", "aliases": [], "types": ["T044"], "canonical_name": "3-methyladenine DNA glycosylase I"}
{"concept_id": "C3272136", "aliases": [], "types": ["T044"], "canonical_name": "deoxyribonucleate 3-methyladenine glycosidase I"}
{"concept_id": "C3272137", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cell adhesion during single-species biofilm formation"}
{"concept_id": "C3272138", "aliases": ["up-regulation of lipid binding", "upregulation of lipid binding", "up regulation of lipid binding"], "types": ["T044"], "canonical_name": "positive regulation of lipid binding", "definition": "Any process that activates or increases the frequency, rate or extent of lipid binding. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3272139", "aliases": ["up regulation of receptor binding", "upregulation of receptor binding"], "types": ["T044"], "canonical_name": "positive regulation of receptor binding", "definition": "Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3272140", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of cell adhesion involved in single-species biofilm formation"}
{"concept_id": "C3272142", "aliases": ["up regulation of neurokinin-1 receptor binding", "activation of neurokinin-1 receptor binding", "up regulation of substance P receptor binding", "up-regulation of neurokinin-1 receptor binding", "activation of substance P receptor binding", "upregulation of neurokinin-1 receptor binding", "positive regulation of neurokinin-1 receptor binding", "up-regulation of substance P receptor binding", "upregulation of substance P receptor binding"], "types": ["T044"], "canonical_name": "positive regulation of substance P receptor binding", "definition": "Any process that activates or increases the frequency, rate or extent of substance P receptor binding. [GOC:TermGenie]"}
{"concept_id": "C3272143", "aliases": ["down regulation of lipid binding", "down-regulation of lipid binding", "downregulation of lipid binding"], "types": ["T044"], "canonical_name": "negative regulation of lipid binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3272144", "aliases": ["down-regulation of receptor binding", "downregulation of receptor binding", "down regulation of receptor binding"], "types": ["T044"], "canonical_name": "negative regulation of receptor binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. [GOC:signaling, GOC:TermGenie]"}
{"concept_id": "C3272145", "aliases": ["downregulation of cell adhesion involved in single-species biofilm formation", "down-regulation of cell adhesion involved in single-species biofilm formation", "down regulation of cell adhesion involved in single-species biofilm formation"], "types": ["T043"], "canonical_name": "negative regulation of cell adhesion involved in single-species biofilm formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in single-species biofilm formation. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3272146", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell segregation"}
{"concept_id": "C3272147", "aliases": ["downregulation of neurokinin-1 receptor binding", "negative regulation of neurokinin-1 receptor binding", "inhibition of substance P receptor binding", "inhibition of neurokinin-1 receptor binding", "down regulation of neurokinin-1 receptor binding", "down-regulation of substance P receptor binding", "down-regulation of neurokinin-1 receptor binding", "downregulation of substance P receptor binding", "down regulation of substance P receptor binding"], "types": ["T044"], "canonical_name": "negative regulation of substance P receptor binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of substance P receptor binding. [GOC:TermGenie]"}
{"concept_id": "C3272148", "aliases": ["down regulation of chemokine activity", "down-regulation of chemokine activity", "downregulation of chemokine activity"], "types": ["T044"], "canonical_name": "negative regulation of chemokine activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity. [GOC:TermGenie]"}
{"concept_id": "C3272149", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell adhesion involved in single-species biofilm formation"}
{"concept_id": "C3272150", "aliases": [], "types": ["T038"], "canonical_name": "regulation of pro-B cell development"}
{"concept_id": "C3272151", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of plasma cell differentiation"}
{"concept_id": "C3272152", "aliases": [], "types": ["T038"], "canonical_name": "regulation of plasma cell development"}
{"concept_id": "C3272153", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of plasma cell development"}
{"concept_id": "C3272154", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of plasma cell development"}
{"concept_id": "C3272155", "aliases": [], "types": ["T038"], "canonical_name": "activation of plasma cell development"}
{"concept_id": "C3272156", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of pro-B cell development"}
{"concept_id": "C3272157", "aliases": [], "types": ["T038"], "canonical_name": "regulation of trichome distribution"}
{"concept_id": "C3272158", "aliases": [], "types": ["T038"], "canonical_name": "regulation of trichome pattern specification"}
{"concept_id": "C3272159", "aliases": ["negative regulation of trichome distribution", "downregulation of trichome distribution", "down-regulation of trichome distribution", "inhibition of trichome distribution"], "types": ["T038"], "canonical_name": "down regulation of trichome distribution"}
{"concept_id": "C3272160", "aliases": ["downregulation of trichome pattern specification", "downregulation of trichome patterning", "down-regulation of trichome pattern specification", "down-regulation of trichome patterning", "down regulation of trichome patterning"], "types": ["T038"], "canonical_name": "down regulation of trichome pattern specification"}
{"concept_id": "C3272161", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of trichome pattern specification"}
{"concept_id": "C3272162", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of trichome patterning"}
{"concept_id": "C3272163", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of trichome pattern specification"}
{"concept_id": "C3272164", "aliases": [], "types": ["T043"], "canonical_name": "up regulation of dendrite development"}
{"concept_id": "C3272165", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Schwann cell migration"}
{"concept_id": "C3272166", "aliases": [], "types": ["T043"], "canonical_name": "activation of Schwann cell migration"}
{"concept_id": "C3272167", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of oocyte maturation"}
{"concept_id": "C3272168", "aliases": [], "types": ["T043"], "canonical_name": "activation of oocyte maturation"}
{"concept_id": "C3272169", "aliases": ["inhibition of protein localization in nucleus", "inhibition of protein localization to nucleus", "inhibition of protein localization in cell nucleus"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to nucleus"}
{"concept_id": "C3272170", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of execution phase of apoptosis"}
{"concept_id": "C3272171", "aliases": ["inhibition of nodal receptor complex formation", "inhibition of nodal receptor complex assembly"], "types": ["T043"], "canonical_name": "inhibition of ActRIIB.ALK4.EGF-CFC complex formation"}
{"concept_id": "C3272172", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hyaluranon cable assembly"}
{"concept_id": "C3272173", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to insulin stimulus"}
{"concept_id": "C3272174", "aliases": ["down-regulation of NLRP3 inflammasome activation", "negative regulation of NLRP3 inflammasome activation", "downregulation of NLRP3 inflammasome activation"], "types": ["T043"], "canonical_name": "down regulation of NLRP3 inflammasome activation"}
{"concept_id": "C3272175", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of NLRP3 inflammasome activation"}
{"concept_id": "C3272176", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of retrograde transport of endocytic vesicles"}
{"concept_id": "C3272177", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of cellular hyperosmotic salinity response"}
{"concept_id": "C3272178", "aliases": ["inhibition of cellular response to hyperosmotic salt stress"], "types": ["T043"], "canonical_name": "inhibition of cellular hyperosmotic salinity response"}
{"concept_id": "C3272179", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synapse assembly"}
{"concept_id": "C3272180", "aliases": ["negative regulation of cellular response to hypoxic stress", "down regulation of cellular response to hypoxic stress", "negative regulation of cellular response to lowered oxygen tension", "down-regulation of cellular response to lowered oxygen tension", "downregulation of cellular response to hypoxia", "inhibition of cellular response to hypoxic stress", "inhibition of cellular response to lowered oxygen tension", "down-regulation of cellular response to hypoxic stress", "downregulation of cellular response to lowered oxygen tension", "inhibition of cellular response to hypoxia", "downregulation of cellular response to hypoxic stress", "down regulation of cellular response to lowered oxygen tension"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to hypoxia", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3272181", "aliases": ["inhibition of cellular response to alkalinity", "inhibition of cellular response to basic pH"], "types": ["T043"], "canonical_name": "inhibition of cellular response to alkaline pH"}
{"concept_id": "C3272182", "aliases": ["downregulation of cellular response to basic pH", "down regulation of cellular response to basic pH", "down-regulation of cellular response to alkaline pH", "downregulation of cellular response to alkalinity", "downregulation of cellular response to alkaline pH", "down-regulation of cellular response to basic pH", "down regulation of cellular response to alkaline pH", "negative regulation of cellular response to basic pH", "negative regulation of cellular response to alkalinity"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to alkaline pH", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity. [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]"}
{"concept_id": "C3272183", "aliases": ["inhibition of synaptic vesicle retrieval"], "types": ["T043"], "canonical_name": "inhibition of synaptic vesicle endocytosis"}
{"concept_id": "C3272184", "aliases": ["down-regulation of synaptic vesicle retrieval", "downregulation of synaptic vesicle retrieval"], "types": ["T043"], "canonical_name": "down regulation of synaptic vesicle retrieval"}
{"concept_id": "C3272185", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transmembrane calcium influx"}
{"concept_id": "C3275312", "aliases": ["foramen ovale of heart closure"], "types": ["T039"], "canonical_name": "foramen ovale closure", "definition": "The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow. [GOC:BHF, GOC:vk, PMID:19762328, UBERON:0004754, Wikipedia:Foramen_ovale_(heart)]"}
{"concept_id": "C3467724", "aliases": [], "types": ["T044"], "canonical_name": "discoidin domain receptor"}
{"concept_id": "C3536735", "aliases": [], "types": ["T026"], "definition": "Structures which form the base of FLAGELLA and CILIA. They contain nine triplets of MICROTUBULES that are arranged around the periphery and that serve as the nucleation center for AXONEME assembly.", "canonical_name": "basal body"}
{"concept_id": "C3536899", "aliases": [], "types": ["T040"], "definition": "A form of symbiosis between two organisms of different species in which one of them benefits from the association whereas the other is largely unaffected or not significantly harmed or benefiting from the relationship.", "canonical_name": "commensalism"}
{"concept_id": "C3537022", "aliases": [], "types": ["T044"], "definition": "Tubulin Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction with highly conserved globular alpha, beta, or gamma tubulin protein subunits of microtubules.", "canonical_name": "tubulin binding"}
{"concept_id": "C3537023", "aliases": ["kinase inhibitor activity"], "types": ["T044"], "definition": "Binds to and stops, prevents or reduces the activity of a kinase. [GOC:mah]", "canonical_name": "kinase inhibitor"}
{"concept_id": "C3537025", "aliases": ["microtubule bundling"], "types": ["T044"], "canonical_name": "microtubule bundle formation", "definition": "A process that results in a parallel arrangement of microtubules. [GOC:dph]"}
{"concept_id": "C3537066", "aliases": [], "types": ["T042"], "definition": "Bone Resorption Stimulation involves initiation of absorption and removal of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium carbonate and release of bone salts (phosphorus and, especially, calcium) into the extracellular fluid by osteoclasts, activated by parathyroid hormone.", "canonical_name": "stimulation of bone resorption"}
{"concept_id": "C3537067", "aliases": [], "types": ["T042"], "definition": "Bone Resorption Inhibition involves interference with, or restraint of, absorption and removal of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium carbonate and release of bone salts (phosphorus and, especially, calcium) into the extracellular fluid by osteoclasts, activated by parathyroid hormone.", "canonical_name": "inhibition of bone resorption"}
{"concept_id": "C3537147", "aliases": [], "types": ["T044"], "canonical_name": "phosphodiesterase inhibitor"}
{"concept_id": "C3537152", "aliases": ["signaling", "biological signaling", "signaling process", "signalling process"], "types": ["T038"], "definition": "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]", "canonical_name": "signalling"}
{"concept_id": "C3537160", "aliases": ["appetite stimulation"], "types": ["T039"], "canonical_name": "stimulation of appetite"}
{"concept_id": "C3537202", "aliases": [], "types": ["T042"], "canonical_name": "ventricular repolarization"}
{"concept_id": "C3537204", "aliases": [], "types": ["T042"], "canonical_name": "atrial repolarization"}
{"concept_id": "C3537205", "aliases": ["AICD", "activation-induced cell death of T-lymphocytes", "activation-induced cell death of T lymphocytes", "activation-induced cell death of T cells"], "types": ["T043"], "definition": "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196, PMID:12414721, PMID:12752672]", "canonical_name": "activation-induced cell death of T-cells"}
{"concept_id": "C3537459", "aliases": [], "types": ["T005"], "canonical_name": "tail structure"}
{"concept_id": "C3538559", "aliases": ["mitochondrial adhaerens complex", "mitochondrion-associated adherens complex location", "MAC", "mitochondrial adhaerens complex location"], "types": ["T026"], "definition": "An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans. [NIF_Subcellular:sao1933817066, PMID:20089910]", "canonical_name": "mitochondrion-associated adherens complex"}
{"concept_id": "C3538943", "aliases": [], "types": ["T044"], "canonical_name": "L-type calcium channel"}
{"concept_id": "C3538944", "aliases": [], "types": ["T044"], "canonical_name": "N-type calcium channel"}
{"concept_id": "C3538949", "aliases": ["PRL signaling pathway", "prolactin-mediated signaling pathway"], "types": ["T044"], "definition": "The series of molecular signals initiated by the binding of the peptide hormone prolactin to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:21664429]", "canonical_name": "prolactin signaling pathway"}
{"concept_id": "C3539011", "aliases": [], "types": ["T044"], "canonical_name": "Q-type calcium channel"}
{"concept_id": "C3539510", "aliases": ["CODH/ACS complex location", "CODH/ACS complex", "acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex location", "acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex", "CO dehydrogenase/acetyl-CoA synthase complex", "CO dehydrogenase/acetyl-CoA synthase complex location"], "types": ["T026"], "definition": "A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis. [GOC:mengo_curators, PMID:11607176, PMID:7693685, PMID:8955306]", "canonical_name": "CODH"}
{"concept_id": "C3539513", "aliases": ["CXCR7", "CXCR4", "C-X-C motif chemokine 12 receptor activity", "stromal cell-derived factor-1 receptor activity"], "types": ["T044"], "definition": "Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, PMID:22204316]", "canonical_name": "CXCL12 receptor activity"}
{"concept_id": "C3540429", "aliases": [], "types": ["T044"], "canonical_name": "epithelial sodium channel"}
{"concept_id": "C3540443", "aliases": ["invasive growth"], "types": ["T043"], "definition": "The growth of colonies in filamentous chains of cells into a substrate. [GOC:di, PMID:22276126]", "canonical_name": "invasive filamentous growth"}
{"concept_id": "C3541190", "aliases": ["down-regulation of store-operated calcium channel activity", "downregulation of store-operated calcium channel activity", "negative regulation of store-operated calcium channel activity"], "types": ["T044"], "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium channel activity. [GOC:TermGenie]", "canonical_name": "down regulation of store-operated calcium channel activity"}
{"concept_id": "C3541201", "aliases": ["O-GlcNAc transferase", "UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase", "OGTase", "protein O-GlcNAc transferase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine. [GOC:jsg, GOC:sart, PMID:22158438]", "canonical_name": "O-linked N-acetylglucosaminyltransferase"}
{"concept_id": "C3541202", "aliases": ["OAP", "orthogonal array"], "types": ["T026"], "definition": "Square array of closely spaced intramembrane particles, 4-6 nm in size, that form supramolecular aggregates found in the plasma membrane of astrocytes, skeletal muscle and epithelial cells. They have been shown to contain aquaporins (water channels). [NIF_Subcellular:sao1747012216, PMID:22718347]", "canonical_name": "orthogonal array of particles"}
{"concept_id": "C3541203", "aliases": [], "types": ["T044"], "canonical_name": "P-type calcium channel"}
{"concept_id": "C3541208", "aliases": ["up-regulation of store-operated calcium channel activity", "up regulation of store-operated calcium channel activity", "upregulation of store-operated calcium channel activity"], "types": ["T044"], "definition": "Any process that activates or increases the frequency, rate or extent of store-operated calcium channel activity. [GOC:TermGenie]", "canonical_name": "positive regulation of store-operated calcium channel activity"}
{"concept_id": "C3541466", "aliases": ["halo"], "types": ["T026"], "definition": "The periphery of a Lewy body. In Parkinson's disease, it contains spherical accumulations of filaments arranged in a loose, radiating array. [NIF_Subcellular:sao5764355747]", "canonical_name": "Lewy body corona"}
{"concept_id": "C3541468", "aliases": ["intermediate voltage-gated calcium channel activity"], "types": ["T044"], "definition": "Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded. [GOC:BHF, GOC:rl, PMID:16382099, Wikipedia:Calcium_channel]", "canonical_name": "R-type calcium channel"}
{"concept_id": "C3541837", "aliases": ["cytoskeleton of presynaptic active zone", "pre-synaptic ribbon", "presynaptic cytoskeletal matrix", "active zone cytomatrix", "ribbon", "CAZ", "presynaptic cytoskeletal matrix assembled at active zones", "presynaptic cytomatrix assembled at active zones", "presynaptic ribbon", "T-bar"], "types": ["T026"], "definition": "The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites. [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438]", "canonical_name": "pre-synaptic cytoskeletal matrix assembled at active zones"}
{"concept_id": "C3542023", "aliases": ["tubulobulbar complex location", "TBC"], "types": ["T026"], "definition": "Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes. [GOC:sl, PMID:22510523]", "canonical_name": "tubulobulbar complex"}
{"concept_id": "C3543859", "aliases": [], "types": ["T026"], "definition": "Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. [NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:sao2409833926]", "canonical_name": "neurofibrillary tangle"}
{"concept_id": "C3544366", "aliases": ["downregulation of egg-laying"], "types": ["T038"], "canonical_name": "downregulation of egg laying"}
{"concept_id": "C3544367", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of iron superoxide oxidoreductase"}
{"concept_id": "C3544368", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of octadecene anabolism"}
{"concept_id": "C3544369", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of olefin formation"}
{"concept_id": "C3544371", "aliases": ["down-regulation of pentadecane biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of pentadecane biosynthesis"}
{"concept_id": "C3544372", "aliases": [], "types": ["T026"], "canonical_name": "Papp-Lantos body"}
{"concept_id": "C3544373", "aliases": ["vesicle scission"], "types": ["T043"], "canonical_name": "vesicle scission", "definition": "The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane. [PMID:21779028]"}
{"concept_id": "C3544374", "aliases": ["cyclo-L-Trp-L-Pro biosynthetic process", "cyclo-L-Trp-L-Pro formation", "cyclo-L-Trp-L-Pro biosynthesis", "cyclo-L-Trp-L-Pro synthesis"], "types": ["T044"], "canonical_name": "cyclo-L-Trp-L-Pro anabolism"}
{"concept_id": "C3544375", "aliases": ["cyclo-L-Trp-L-Pro catabolism", "cyclo-L-Trp-L-Pro degradation", "cyclo-L-Trp-L-Pro catabolic process"], "types": ["T044"], "canonical_name": "cyclo-L-Trp-L-Pro breakdown"}
{"concept_id": "C3544376", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mitochondrial DNA metabolic process"}
{"concept_id": "C3544377", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of respiration"}
{"concept_id": "C3544378", "aliases": ["downregulation of superoxide dismutase I", "down regulation of SOD-1", "negative regulation of SOD-1", "down regulation of superoxide dismutase I", "inhibition of superoxide dismutase I", "down-regulation of SOD-1", "inhibition of SOD-1", "negative regulation of superoxide dismutase I", "down-regulation of superoxide dismutase I"], "types": ["T044"], "canonical_name": "downregulation of SOD-1"}
{"concept_id": "C3544379", "aliases": ["inhibition of iron superoxide dismutase activity", "inhibition of iron superoxide oxidoreductase", "down regulation of ferrisuperoxide dismutase activity", "down-regulation of manganese superoxide oxidoreductase", "inhibition of ferrisuperoxide dismutase activity", "downregulation of Mn-SOD", "negative regulation of manganese superoxide dismutase activity", "down regulation of Mn-SOD", "down regulation of iron superoxide oxidoreductase", "down regulation of manganese superoxide oxidoreductase", "inhibition of manganese superoxide oxidoreductase", "downregulation of manganese superoxide oxidoreductase", "negative regulation of Mn-SOD", "negative regulation of manganese superoxide oxidoreductase", "down-regulation of Mn-SOD", "negative regulation of iron superoxide oxidoreductase", "down-regulation of Fe-SOD", "down regulation of Mn, Fe superoxide dismutase", "downregulation of iron superoxide dismutase activity", "downregulation of Fe-SOD", "down-regulation of manganese superoxide dismutase activity", "inhibition of Fe-SOD", "down regulation of Fe-SOD", "downregulation of iron superoxide oxidoreductase", "negative regulation of Fe-SOD", "down regulation of iron superoxide dismutase activity", "negative regulation of Mn, Fe superoxide dismutase", "down-regulation of Mn, Fe superoxide dismutase", "inhibition of Mn-SOD", "inhibition of Mn, Fe superoxide dismutase", "down-regulation of iron superoxide dismutase activity", "inhibition of manganese superoxide dismutase activity", "negative regulation of ferrisuperoxide dismutase activity", "downregulation of Mn, Fe superoxide dismutase", "down-regulation of ferrisuperoxide dismutase activity", "down-regulation of iron superoxide oxidoreductase", "downregulation of manganese superoxide dismutase activity", "down regulation of manganese superoxide dismutase activity", "negative regulation of iron superoxide dismutase activity"], "types": ["T044"], "canonical_name": "downregulation of ferrisuperoxide dismutase activity"}
{"concept_id": "C3544381", "aliases": ["down-regulation of dibenzo-p-diazine biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of dibenzo-p-diazine biosynthetic process"}
{"concept_id": "C3544383", "aliases": ["cell cycle transition"], "types": ["T043"], "canonical_name": "cell cycle phase transition", "definition": "The cell cycle process by which a cell commits to entering the next cell cycle phase. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3544384", "aliases": [], "types": ["T026"], "canonical_name": "Schwann cell paranodal termination"}
{"concept_id": "C3544385", "aliases": [], "types": ["T043"], "canonical_name": "pro-survival"}
{"concept_id": "C3544386", "aliases": [], "types": ["T039"], "definition": "The ability of an organism to reduce susceptibility to heat shock, and adapt to HOT TEMPERATURE.", "canonical_name": "thermotolerance"}
{"concept_id": "C3544387", "aliases": ["catechol biosynthetic process", "catechol synthesis", "catechol formation", "catechol anabolism"], "types": ["T044"], "canonical_name": "catechol biosynthesis"}
{"concept_id": "C3544388", "aliases": [], "types": ["T026"], "canonical_name": "muscle arm"}
{"concept_id": "C3544389", "aliases": [], "types": ["T045"], "canonical_name": "tRNA 5-methylcytosine biosynthesis"}
{"concept_id": "C3544390", "aliases": ["C6H6O4 biosynthesis", "C6H6O4 synthesis", "C6H6O4 biosynthetic process", "C6H6O4 formation"], "types": ["T044"], "canonical_name": "C6H6O4 anabolism"}
{"concept_id": "C3544391", "aliases": ["C6H6O4 metabolism"], "types": ["T044"], "canonical_name": "C6H6O4 metabolic process"}
{"concept_id": "C3544392", "aliases": [], "types": ["T044"], "canonical_name": "arabinoxylan catabolic process"}
{"concept_id": "C3544393", "aliases": [], "types": ["T039"], "canonical_name": "regulation of shoot branching"}
{"concept_id": "C3544394", "aliases": ["regulation of axillary shoot formation"], "types": ["T038"], "canonical_name": "regulation of auxiliary shoot formation"}
{"concept_id": "C3544395", "aliases": ["R2TP/prefoldin-like complex location"], "types": ["T026"], "canonical_name": "R2TP/prefoldin-like complex"}
{"concept_id": "C3544396", "aliases": [], "types": ["T044"], "canonical_name": "aromatic aldehyde synthase"}
{"concept_id": "C3544397", "aliases": [], "types": ["T043"], "canonical_name": "stress-induced mitochondrial hyperfusion"}
{"concept_id": "C3544398", "aliases": ["SIMH"], "types": ["T043"], "canonical_name": "stress-induced mitochondrial fusion", "definition": "Merging of two or more mitochondria within a cell to form a single compartment, as a result of a disturbance in cellular homeostasis. [GOC:lb, PMID:19360003]"}
{"concept_id": "C3544399", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial fusion in response to stress"}
{"concept_id": "C3544400", "aliases": [], "types": ["T026"], "canonical_name": "mossy fiber expansion"}
{"concept_id": "C3544401", "aliases": [], "types": ["T026"], "canonical_name": "dentate gyrus mossy fiber expansion"}
{"concept_id": "C3544402", "aliases": [], "types": ["T026"], "canonical_name": "dentate gyrus granule cell axonal bouton"}
{"concept_id": "C3544403", "aliases": [], "types": ["T026"], "definition": "The main axon connection from the CA3 PYRAMIDAL CELL AREA to the CA1 PYRAMIDAL CELL AREA in the HIPPOCAMPUS. Schaffer collaterals are important in memory, learning and activity-related NEURONAL PLASTICITY.", "canonical_name": "Schaffer collateral"}
{"concept_id": "C3544404", "aliases": [], "types": ["T026"], "canonical_name": "recurrent collateral"}
{"concept_id": "C3544405", "aliases": [], "types": ["T026"], "canonical_name": "tail portion"}
{"concept_id": "C3544406", "aliases": [], "types": ["T026"], "canonical_name": "somatic portion"}
{"concept_id": "C3544407", "aliases": [], "types": ["T026"], "canonical_name": "neck portion"}
{"concept_id": "C3544408", "aliases": [], "types": ["T026"], "canonical_name": "ensheathing process of Schwann cell"}
{"concept_id": "C3544409", "aliases": [], "types": ["T026"], "canonical_name": "square array"}
{"concept_id": "C3544410", "aliases": ["complex location laminated body", "CLB"], "types": ["T026"], "definition": "A cytoplasmic inclusion body found in some lateral geniculate neurons and composed of sheets of tubules (25 nm in diameter) separated by dense material (about 75 nm wide), which together with the tubules whorl give a structure resembling a fingerprint. [NIF_Subcellular:nlx_151681]", "canonical_name": "complex laminated body"}
{"concept_id": "C3544411", "aliases": ["amyloid structure formation"], "types": ["T044"], "canonical_name": "amyloid structure assembly"}
{"concept_id": "C3544412", "aliases": ["amyloid fibril assembly"], "types": ["T044"], "canonical_name": "amyloid fibril formation", "definition": "The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159]"}
{"concept_id": "C3544413", "aliases": ["up regulation of Fas-FasL signaling pathway", "up-regulation of Fas-FasL signaling pathway", "up-regulation of FasL signaling pathway", "up regulation of FasL signaling pathway"], "types": ["T044"], "canonical_name": "upregulation of FasL signaling pathway"}
{"concept_id": "C3544414", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of Fas-FasL signaling pathway"}
{"concept_id": "C3544415", "aliases": ["up-regulation of FAS ligand-Fas signaling pathway", "up regulation of FAS ligand-Fas signaling pathway"], "types": ["T044"], "canonical_name": "upregulation of FAS ligand-Fas signaling pathway"}
{"concept_id": "C3544416", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of FasL signaling pathway"}
{"concept_id": "C3544417", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Fas-FasL signaling pathway"}
{"concept_id": "C3544418", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of FAS ligand-Fas signaling pathway"}
{"concept_id": "C3544419", "aliases": [], "types": ["T044"], "canonical_name": "activation of FasR signaling pathway"}
{"concept_id": "C3544420", "aliases": [], "types": ["T044"], "canonical_name": "activation of FasL signaling pathway"}
{"concept_id": "C3544421", "aliases": [], "types": ["T044"], "canonical_name": "activation of Fas-FasL signaling pathway"}
{"concept_id": "C3544422", "aliases": [], "types": ["T044"], "canonical_name": "activation of Fas signaling pathway"}
{"concept_id": "C3544423", "aliases": [], "types": ["T044"], "canonical_name": "activation of Fas receptor signaling pathway"}
{"concept_id": "C3544424", "aliases": [], "types": ["T044"], "canonical_name": "activation of FAS ligand-Fas signaling pathway"}
{"concept_id": "C3544425", "aliases": [], "types": ["T044"], "canonical_name": "activation of CD95 signaling pathway"}
{"concept_id": "C3544426", "aliases": [], "types": ["T044"], "canonical_name": "activation of Apo-1 signaling pathway"}
{"concept_id": "C3544427", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of FasL signaling pathway"}
{"concept_id": "C3544428", "aliases": ["negative regulation of FAS ligand-Fas signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of Fas-FasL signaling pathway"}
{"concept_id": "C3544429", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of FasR signaling pathway"}
{"concept_id": "C3544430", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of FasL signaling pathway"}
{"concept_id": "C3544431", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Fas-FasL signaling pathway"}
{"concept_id": "C3544432", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Fas signaling pathway"}
{"concept_id": "C3544433", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Fas receptor signaling pathway"}
{"concept_id": "C3544434", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of FAS ligand-Fas signaling pathway"}
{"concept_id": "C3544435", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CD95 signaling pathway"}
{"concept_id": "C3544436", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Apo-1 signaling pathway"}
{"concept_id": "C3544437", "aliases": ["down-regulation of Fas-FasL signaling pathway", "down regulation of Fas-FasL signaling pathway", "down regulation of FAS ligand-Fas signaling pathway", "downregulation of FasL signaling pathway", "downregulation of FAS ligand-Fas signaling pathway", "down regulation of FasL signaling pathway", "down-regulation of FAS ligand-Fas signaling pathway", "down-regulation of FasL signaling pathway"], "types": ["T044"], "canonical_name": "downregulation of Fas-FasL signaling pathway"}
{"concept_id": "C3544438", "aliases": [], "types": ["T044"], "canonical_name": "regulation of FasL signaling pathway"}
{"concept_id": "C3544439", "aliases": ["regulation of FAS ligand-Fas signaling pathway"], "types": ["T044"], "canonical_name": "regulation of Fas-FasL signaling pathway"}
{"concept_id": "C3544440", "aliases": ["up-regulation of death receptor-mediated apoptosis", "up regulation of death receptor-mediated apoptosis"], "types": ["T044"], "canonical_name": "upregulation of death receptor-mediated apoptosis"}
{"concept_id": "C3544441", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of death receptor-mediated apoptosis"}
{"concept_id": "C3544442", "aliases": [], "types": ["T044"], "canonical_name": "activation of extrinsic apoptotic signaling pathway via death domain receptors"}
{"concept_id": "C3544443", "aliases": [], "types": ["T044"], "canonical_name": "activation of death receptor-mediated apoptosis"}
{"concept_id": "C3544444", "aliases": ["negative regulation of death receptor-mediated apoptosis", "down regulation of death receptor-mediated apoptosis", "down-regulation of death receptor-mediated apoptosis"], "types": ["T044"], "canonical_name": "downregulation of death receptor-mediated apoptosis"}
{"concept_id": "C3544445", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of extrinsic apoptotic signaling pathway via death domain receptors"}
{"concept_id": "C3544446", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of death receptor-mediated apoptosis"}
{"concept_id": "C3544447", "aliases": [], "types": ["T044"], "canonical_name": "regulation of death receptor-mediated apoptosis"}
{"concept_id": "C3544448", "aliases": ["up-regulation of seed dormancy", "up regulation of seed dormancy"], "types": ["T044"], "canonical_name": "upregulation of seed dormancy"}
{"concept_id": "C3544449", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of seed dormancy"}
{"concept_id": "C3544450", "aliases": [], "types": ["T040"], "canonical_name": "activation of seed dormancy process"}
{"concept_id": "C3544451", "aliases": [], "types": ["T040"], "canonical_name": "activation of seed dormancy"}
{"concept_id": "C3544452", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of seed dormancy"}
{"concept_id": "C3544453", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of seed dormancy process"}
{"concept_id": "C3544454", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of seed dormancy"}
{"concept_id": "C3544455", "aliases": ["down regulation of seed dormancy", "down-regulation of seed dormancy"], "types": ["T040"], "canonical_name": "downregulation of seed dormancy"}
{"concept_id": "C3544456", "aliases": ["activation of hemopoietic stem cell differentiation"], "types": ["T043"], "canonical_name": "activation of haemopoietic stem cell differentiation"}
{"concept_id": "C3544457", "aliases": ["activation of hematopoietic stem cell differentiation"], "types": ["T043"], "canonical_name": "activation of haematopoietic stem cell differentiation"}
{"concept_id": "C3544458", "aliases": ["inhibition of hemopoietic stem cell differentiation"], "types": ["T043"], "canonical_name": "inhibition of haemopoietic stem cell differentiation"}
{"concept_id": "C3544459", "aliases": ["inhibition of hematopoietic stem cell differentiation"], "types": ["T043"], "canonical_name": "inhibition of haematopoietic stem cell differentiation"}
{"concept_id": "C3544460", "aliases": ["activation of hemopoietic stem cell proliferation"], "types": ["T043"], "canonical_name": "activation of hematopoietic stem cell proliferation"}
{"concept_id": "C3544461", "aliases": ["inhibition of hemopoietic stem cell proliferation"], "types": ["T043"], "canonical_name": "inhibition of hematopoietic stem cell proliferation"}
{"concept_id": "C3544462", "aliases": ["regulation of NAD phosphorylation and dephosphorylation"], "types": ["T044"], "canonical_name": "regulation of NAD phosphorylation and dephosphorylation"}
{"concept_id": "C3544463", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H3-K18 acetylation"}
{"concept_id": "C3544464", "aliases": [], "types": ["T044"], "canonical_name": "activation of histone H3-K18 acetylation"}
{"concept_id": "C3544465", "aliases": [], "types": ["T043"], "canonical_name": "activation of cartilage condensation"}
{"concept_id": "C3544466", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ciliary cell motility"}
{"concept_id": "C3544467", "aliases": ["downregulation of cilium assembly", "down regulation of cilium assembly", "negative regulation of ciliogenesis", "inhibition of ciliogenesis", "down-regulation of ciliogenesis", "down regulation of ciliogenesis", "downregulation of ciliogenesis", "negative regulation of cilium biogenesis", "down-regulation of cilium assembly"], "types": ["T043"], "canonical_name": "negative regulation of cilium assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]"}
{"concept_id": "C3544468", "aliases": ["inhibition of cilium biogenesis"], "types": ["T043"], "canonical_name": "inhibition of cilium assembly"}
{"concept_id": "C3544469", "aliases": ["down regulation of cilium biogenesis", "down-regulation of cilium biogenesis"], "types": ["T043"], "canonical_name": "downregulation of cilium biogenesis"}
{"concept_id": "C3544470", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cilium biogenesis"}
{"concept_id": "C3544471", "aliases": ["protein biosynthetic process inhibitor activity involved in response to ER stress"], "types": ["T045"], "canonical_name": "protein biosynthetic process inhibitor activity involved in ER stress response"}
{"concept_id": "C3544472", "aliases": [], "types": ["T044"], "canonical_name": "protein biosynthetic process inhibitor activity involved in response to endoplasmic reticulum stress"}
{"concept_id": "C3544473", "aliases": ["protein biosynthesis inhibitor activity involved in response to ER stress"], "types": ["T045"], "canonical_name": "protein biosynthesis inhibitor activity involved in ER stress response"}
{"concept_id": "C3544474", "aliases": [], "types": ["T044"], "canonical_name": "protein biosynthesis inhibitor activity involved in response to endoplasmic reticulum stress"}
{"concept_id": "C3544475", "aliases": ["inhibition of protein biosynthetic process involved in response to ER stress"], "types": ["T045"], "canonical_name": "inhibition of protein biosynthetic process involved in ER stress response"}
{"concept_id": "C3544476", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein biosynthetic process involved in response to endoplasmic reticulum stress"}
{"concept_id": "C3544477", "aliases": [], "types": ["T043"], "canonical_name": "activation of toxin transport"}
{"concept_id": "C3544478", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of toxin transport"}
{"concept_id": "C3544479", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of proline biosynthetic process"}
{"concept_id": "C3544480", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-amyloid formation"}
{"concept_id": "C3544481", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of indoleacetic acid biosynthetic process via tryptophan"}
{"concept_id": "C3544482", "aliases": ["up regulation of cell cycle phase transition", "upregulation of cell cycle transition", "positive regulation of cell cycle transition", "activation of cell cycle transition", "up-regulation of cell cycle transition", "upregulation of cell cycle phase transition", "up regulation of cell cycle transition", "up-regulation of cell cycle phase transition"], "types": ["T043"], "canonical_name": "positive regulation of cell cycle phase transition", "definition": "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]"}
{"concept_id": "C3544483", "aliases": [], "types": ["T043"], "canonical_name": "activation of meiotic cell cycle phase transition"}
{"concept_id": "C3544484", "aliases": ["negative regulation of cell cycle transition", "down regulation of cell cycle phase transition", "downregulation of cell cycle transition", "downregulation of cell cycle phase transition", "down-regulation of cell cycle phase transition", "down-regulation of cell cycle transition", "down regulation of cell cycle transition", "inhibition of cell cycle transition"], "types": ["T043"], "canonical_name": "negative regulation of cell cycle phase transition", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]"}
{"concept_id": "C3544485", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of meiotic cell cycle phase transition"}
{"concept_id": "C3544486", "aliases": ["regulation of cell cycle phase transition", "regulation of cell cycle transition"], "types": ["T043"], "definition": "Any process that modulates the frequency, rate or extent of cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "canonical_name": "cell cycle control"}
{"concept_id": "C3544487", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic cell cycle phase transition"}
{"concept_id": "C3544488", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic cell cycle phase transition"}
{"concept_id": "C3544489", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell cycle phase transition"}
{"concept_id": "C3544490", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell cycle phase transition"}
{"concept_id": "C3544491", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein amino acid acetylation"}
{"concept_id": "C3544492", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein acetylation"}
{"concept_id": "C3544493", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein amino acid acetylation"}
{"concept_id": "C3544494", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein acetylation"}
{"concept_id": "C3544495", "aliases": [], "types": ["T044"], "canonical_name": "activation of inward rectifier potassium channel activity"}
{"concept_id": "C3544496", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell cycle checkpoint"}
{"concept_id": "C3544497", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell cycle checkpoint"}
{"concept_id": "C3544498", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA-5-methylcytosine glycosylase activity"}
{"concept_id": "C3544499", "aliases": ["up regulation of mitotic chromosome separation", "up-regulation of mitotic chromosome separation"], "types": ["T043"], "canonical_name": "upregulation of mitotic chromosome separation"}
{"concept_id": "C3544500", "aliases": ["upregulation of chromosome separation during mitosis", "up regulation of chromosome separation during mitosis", "up-regulation of chromosome separation during mitosis"], "types": ["T043"], "canonical_name": "positive regulation of chromosome separation during mitosis"}
{"concept_id": "C3544501", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic chromosome separation"}
{"concept_id": "C3544502", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic sister chromatid separation"}
{"concept_id": "C3544503", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic chromosome separation"}
{"concept_id": "C3544504", "aliases": [], "types": ["T043"], "canonical_name": "activation of chromosome separation during mitosis"}
{"concept_id": "C3544505", "aliases": [], "types": ["T044"], "canonical_name": "activation of polynucleotide 3'-phosphatase activity"}
{"concept_id": "C3544506", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to iron ion starvation"}
{"concept_id": "C3544507", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell proliferation involved in outflow tract morphogenesis"}
{"concept_id": "C3544508", "aliases": [], "types": ["T044"], "canonical_name": "activation of cutin biosynthetic process"}
{"concept_id": "C3544509", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cutin biosynthetic process"}
{"concept_id": "C3544510", "aliases": [], "types": ["T043"], "canonical_name": "activation of retrograde dense core granule transport"}
{"concept_id": "C3544511", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of retrograde dense core granule transport"}
{"concept_id": "C3544512", "aliases": [], "types": ["T044"], "canonical_name": "activation of anterograde dense core granule transport"}
{"concept_id": "C3544513", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of anterograde dense core granule transport"}
{"concept_id": "C3544518", "aliases": ["negative regulation of protein import into nucleus during mitotic cell cycle spindle assembly checkpoint", "KTIP"], "types": ["T043"], "canonical_name": "negative regulation of protein import into nucleus during spindle assembly checkpoint", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p). [GOC:dgf, GOC:TermGenie, PMID:23177738]"}
{"concept_id": "C3544519", "aliases": [], "types": ["T043"], "canonical_name": "Kap121p transport inhibitory pathway"}
{"concept_id": "C3544524", "aliases": [], "types": ["T039"], "canonical_name": "activation of sclerotium development"}
{"concept_id": "C3544525", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of sclerotium development"}
{"concept_id": "C3544526", "aliases": ["peptidyl-tyrosine dephosphorylation involved in protein kinase activation"], "types": ["T044"], "canonical_name": "peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity", "definition": "Any peptidyl-tyrosine dephosphorylation that is involved in activation of protein kinase activity. [GOC:TermGenie, PMID:1756737]"}
{"concept_id": "C3544527", "aliases": [], "types": ["T045"], "canonical_name": "activation of exoribonuclease activity"}
{"concept_id": "C3544528", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of exoribonuclease activity"}
{"concept_id": "C3544530", "aliases": ["up-regulation of capsule organization and biogenesis", "up regulation of capsule organization and biogenesis"], "types": ["T043"], "canonical_name": "upregulation of capsule organization and biogenesis"}
{"concept_id": "C3544531", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of capsule organization and biogenesis"}
{"concept_id": "C3544532", "aliases": [], "types": ["T043"], "canonical_name": "activation of capsule organization and biogenesis"}
{"concept_id": "C3544533", "aliases": ["activation of capsule organization"], "types": ["T043"], "canonical_name": "activation of capsule organisation"}
{"concept_id": "C3544534", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of capsule organization and biogenesis"}
{"concept_id": "C3544535", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of capsule organization and biogenesis"}
{"concept_id": "C3544536", "aliases": ["inhibition of capsule organization"], "types": ["T043"], "canonical_name": "inhibition of capsule organisation"}
{"concept_id": "C3544537", "aliases": ["down regulation of capsule organization and biogenesis", "down-regulation of capsule organization and biogenesis"], "types": ["T043"], "canonical_name": "downregulation of capsule organization and biogenesis"}
{"concept_id": "C3544538", "aliases": [], "types": ["T043"], "canonical_name": "regulation of capsule organization and biogenesis"}
{"concept_id": "C3544540", "aliases": [], "types": ["T039"], "canonical_name": "activation of relaxation of cardiac muscle"}
{"concept_id": "C3544541", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of relaxation of cardiac muscle"}
{"concept_id": "C3544542", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of sarcoplasmic reticulum ATPase"}
{"concept_id": "C3544543", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C3544544", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of plasma membrane Ca-ATPase"}
{"concept_id": "C3544545", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of calcium-translocating P-type ATPase activity"}
{"concept_id": "C3544546", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of calcium pump"}
{"concept_id": "C3544547", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of calcium efflux ATPase"}
{"concept_id": "C3544548", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of calcium ABC transporter"}
{"concept_id": "C3544549", "aliases": ["up-regulation of sarcoplasmic reticulum ATPase"], "types": ["T044"], "canonical_name": "up regulation of sarcoplasmic reticulum ATPase"}
{"concept_id": "C3544550", "aliases": ["up-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase"], "types": ["T044"], "canonical_name": "up regulation of sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C3544551", "aliases": ["up-regulation of plasma membrane Ca-ATPase"], "types": ["T044"], "canonical_name": "up regulation of plasma membrane Ca-ATPase"}
{"concept_id": "C3544552", "aliases": ["up-regulation of calcium-translocating P-type ATPase activity"], "types": ["T044"], "canonical_name": "up regulation of calcium-translocating P-type ATPase activity"}
{"concept_id": "C3544553", "aliases": ["up-regulation of calcium pump"], "types": ["T044"], "canonical_name": "up regulation of calcium pump"}
{"concept_id": "C3544554", "aliases": ["up-regulation of calcium efflux ATPase"], "types": ["T044"], "canonical_name": "up regulation of calcium efflux ATPase"}
{"concept_id": "C3544555", "aliases": ["up-regulation of calcium ABC transporter"], "types": ["T044"], "canonical_name": "up regulation of calcium ABC transporter"}
{"concept_id": "C3544556", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of sarcoplasmic reticulum ATPase"}
{"concept_id": "C3544557", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C3544558", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of plasma membrane Ca-ATPase"}
{"concept_id": "C3544559", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of calcium-translocating P-type ATPase activity"}
{"concept_id": "C3544560", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of calcium pump"}
{"concept_id": "C3544561", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of calcium efflux ATPase"}
{"concept_id": "C3544562", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of calcium ABC transporter"}
{"concept_id": "C3544563", "aliases": [], "types": ["T044"], "canonical_name": "activation of sarcoplasmic reticulum ATPase"}
{"concept_id": "C3544564", "aliases": [], "types": ["T044"], "canonical_name": "activation of sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C3544565", "aliases": [], "types": ["T044"], "canonical_name": "activation of plasma membrane Ca-ATPase"}
{"concept_id": "C3544567", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium-translocating P-type ATPase activity"}
{"concept_id": "C3544568", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium pump"}
{"concept_id": "C3544569", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium efflux ATPase"}
{"concept_id": "C3544570", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium ABC transporter"}
{"concept_id": "C3544571", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of sarcoplasmic reticulum ATPase"}
{"concept_id": "C3544572", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C3544573", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of plasma membrane Ca-ATPase"}
{"concept_id": "C3544574", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of calcium-translocating P-type ATPase activity"}
{"concept_id": "C3544575", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of calcium pump"}
{"concept_id": "C3544576", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of calcium efflux ATPase"}
{"concept_id": "C3544577", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of calcium ABC transporter"}
{"concept_id": "C3544578", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sarcoplasmic reticulum ATPase"}
{"concept_id": "C3544579", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C3544580", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of plasma membrane Ca-ATPase"}
{"concept_id": "C3544582", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcium-translocating P-type ATPase activity"}
{"concept_id": "C3544583", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcium pump"}
{"concept_id": "C3544584", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcium efflux ATPase"}
{"concept_id": "C3544585", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcium ABC transporter"}
{"concept_id": "C3544586", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of sarcoplasmic reticulum ATPase"}
{"concept_id": "C3544587", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C3544588", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of plasma membrane Ca-ATPase"}
{"concept_id": "C3544589", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of calcium-translocating P-type ATPase activity"}
{"concept_id": "C3544590", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of calcium pump"}
{"concept_id": "C3544591", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of calcium efflux ATPase"}
{"concept_id": "C3544592", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of calcium ABC transporter"}
{"concept_id": "C3544593", "aliases": ["down-regulation of sarcoplasmic reticulum ATPase"], "types": ["T044"], "canonical_name": "down regulation of sarcoplasmic reticulum ATPase"}
{"concept_id": "C3544594", "aliases": ["down-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase"], "types": ["T044"], "canonical_name": "down regulation of sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C3544595", "aliases": ["down-regulation of plasma membrane Ca-ATPase"], "types": ["T044"], "canonical_name": "down regulation of plasma membrane Ca-ATPase"}
{"concept_id": "C3544596", "aliases": ["down-regulation of calcium-translocating P-type ATPase activity"], "types": ["T044"], "canonical_name": "down regulation of calcium-translocating P-type ATPase activity"}
{"concept_id": "C3544597", "aliases": ["down-regulation of calcium pump"], "types": ["T044"], "canonical_name": "down regulation of calcium pump"}
{"concept_id": "C3544598", "aliases": ["down-regulation of calcium efflux ATPase"], "types": ["T044"], "canonical_name": "down regulation of calcium efflux ATPase"}
{"concept_id": "C3544599", "aliases": ["down-regulation of calcium ABC transporter"], "types": ["T044"], "canonical_name": "down regulation of calcium ABC transporter"}
{"concept_id": "C3544600", "aliases": [], "types": ["T044"], "canonical_name": "regulation of sarcoplasmic reticulum ATPase"}
{"concept_id": "C3544601", "aliases": [], "types": ["T044"], "canonical_name": "regulation of sarco(endo)plasmic reticulum Ca2+-ATPase"}
{"concept_id": "C3544602", "aliases": [], "types": ["T044"], "canonical_name": "regulation of plasma membrane Ca-ATPase"}
{"concept_id": "C3544603", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcium-translocating P-type ATPase activity"}
{"concept_id": "C3544604", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcium pump"}
{"concept_id": "C3544605", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcium efflux ATPase"}
{"concept_id": "C3544606", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcium ABC transporter"}
{"concept_id": "C3544607", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell septum assembly"}
{"concept_id": "C3544608", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell septum assembly"}
{"concept_id": "C3544609", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell junction assembly"}
{"concept_id": "C3544610", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell junction assembly"}
{"concept_id": "C3544611", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein depolymerization"}
{"concept_id": "C3544612", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein depolymerization"}
{"concept_id": "C3544613", "aliases": ["up-regulation of calcium ion storage activity", "up regulation of calcium ion storage activity"], "types": ["T044"], "canonical_name": "upregulation of calcium ion storage activity"}
{"concept_id": "C3544614", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of calcium ion storage activity"}
{"concept_id": "C3544615", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium ion storage activity"}
{"concept_id": "C3544616", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium ion binding"}
{"concept_id": "C3544617", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of calcium ion storage activity"}
{"concept_id": "C3544618", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcium ion storage activity"}
{"concept_id": "C3544619", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcium ion binding"}
{"concept_id": "C3544620", "aliases": ["down-regulation of calcium ion storage activity", "down regulation of calcium ion storage activity"], "types": ["T044"], "canonical_name": "downregulation of calcium ion storage activity"}
{"concept_id": "C3544621", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcium ion storage activity"}
{"concept_id": "C3544622", "aliases": [], "types": ["T044"], "canonical_name": "activation of post-translational protein modification"}
{"concept_id": "C3544623", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of post-translational protein modification"}
{"concept_id": "C3544624", "aliases": [], "types": ["T039"], "canonical_name": "activation of muscle tissue development"}
{"concept_id": "C3544625", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of muscle tissue development"}
{"concept_id": "C3544626", "aliases": [], "types": ["T045"], "canonical_name": "activation of mitochondrial DNA metabolic process"}
{"concept_id": "C3544627", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of respiration"}
{"concept_id": "C3544628", "aliases": ["up-regulation of respiration"], "types": ["T044"], "canonical_name": "up regulation of respiration"}
{"concept_id": "C3544629", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of respiration"}
{"concept_id": "C3544630", "aliases": [], "types": ["T039"], "canonical_name": "activation of respiration"}
{"concept_id": "C3544631", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular respiration"}
{"concept_id": "C3544632", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of respiration"}
{"concept_id": "C3544633", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular respiration"}
{"concept_id": "C3544634", "aliases": [], "types": ["T039"], "canonical_name": "downregulation of respiration"}
{"concept_id": "C3544635", "aliases": ["down-regulation of respiration"], "types": ["T044"], "canonical_name": "down regulation of respiration"}
{"concept_id": "C3544636", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell communication by electrical coupling involved in cardiac conduction"}
{"concept_id": "C3544637", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell communication by electrical coupling involved in cardiac conduction"}
{"concept_id": "C3544640", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA polymerase I regulatory region sequence-specific DNA binding"}
{"concept_id": "C3544641", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter"}
{"concept_id": "C3544642", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription of nuclear large rRNA transcript from RNA polymerase I promoter"}
{"concept_id": "C3544643", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of deadenylation-independent decapping of nuclear mRNA"}
{"concept_id": "C3544644", "aliases": ["up-regulation of deadenylation-independent decapping of nuclear mRNA"], "types": ["T044"], "canonical_name": "up regulation of deadenylation-independent decapping of nuclear mRNA"}
{"concept_id": "C3544645", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of deadenylation-independent decapping of nuclear mRNA"}
{"concept_id": "C3544646", "aliases": [], "types": ["T044"], "canonical_name": "activation of deadenylation-independent decapping of nuclear-transcribed mRNA"}
{"concept_id": "C3544647", "aliases": [], "types": ["T044"], "canonical_name": "activation of deadenylation-independent decapping of nuclear mRNA"}
{"concept_id": "C3544648", "aliases": [], "types": ["T044"], "canonical_name": "regulation of deadenylation-independent decapping of nuclear mRNA"}
{"concept_id": "C3544649", "aliases": [], "types": ["T044"], "canonical_name": "activation of proteasomal protein catabolic process"}
{"concept_id": "C3544650", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of proteasomal protein catabolic process"}
{"concept_id": "C3544651", "aliases": [], "types": ["T044"], "canonical_name": "activation of signal transduction by p53 class mediator"}
{"concept_id": "C3544652", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of signal transduction by p53 class mediator"}
{"concept_id": "C3544653", "aliases": [], "types": ["T043"], "canonical_name": "activation of myoblast fusion"}
{"concept_id": "C3544654", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myoblast fusion"}
{"concept_id": "C3544655", "aliases": ["upregulation of thrombocyte aggregation", "up regulation of thrombocyte aggregation", "up-regulation of thrombocyte aggregation"], "types": ["T043"], "canonical_name": "positive regulation of thrombocyte aggregation"}
{"concept_id": "C3544656", "aliases": [], "types": ["T043"], "canonical_name": "activation of thrombocyte aggregation"}
{"concept_id": "C3544657", "aliases": ["activation of platelet aggregation"], "types": ["T043"], "canonical_name": "activation of blood platelet aggregation"}
{"concept_id": "C3544658", "aliases": [], "types": ["T044"], "canonical_name": "activation of histone deacetylase activity"}
{"concept_id": "C3544659", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone deacetylase activity"}
{"concept_id": "C3544660", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell proliferation involved in kidney development"}
{"concept_id": "C3544661", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell proliferation involved in kidney development"}
{"concept_id": "C3544662", "aliases": [], "types": ["T043"], "canonical_name": "activation of NMS complex interaction involved in chromosome segregation"}
{"concept_id": "C3544663", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of NMS complex interaction involved in chromosome segregation"}
{"concept_id": "C3544664", "aliases": [], "types": ["T044"], "canonical_name": "activation of gamma-aminobutyric acid catabolic process"}
{"concept_id": "C3544665", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of gamma-aminobutyric acid catabolic process"}
{"concept_id": "C3544666", "aliases": [], "types": ["T044"], "canonical_name": "activation of urea catabolic process"}
{"concept_id": "C3544667", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of urea catabolic process"}
{"concept_id": "C3544668", "aliases": [], "types": ["T044"], "canonical_name": "activation of homoserine biosynthetic process"}
{"concept_id": "C3544669", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of homoserine biosynthetic process"}
{"concept_id": "C3544670", "aliases": [], "types": ["T043"], "canonical_name": "activation of compound eye retinal cell apoptotic process"}
{"concept_id": "C3544671", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of compound eye retinal cell apoptotic process"}
{"concept_id": "C3544672", "aliases": [], "types": ["T044"], "canonical_name": "activation of histone H3-K27 acetylation"}
{"concept_id": "C3544673", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H3-K27 acetylation"}
{"concept_id": "C3544674", "aliases": [], "types": ["T039"], "canonical_name": "activation of systemic acquired resistance"}
{"concept_id": "C3544675", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of zinc superoxide oxidoreductase"}
{"concept_id": "C3544676", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of superoxide dismutase II"}
{"concept_id": "C3544677", "aliases": ["upregulation of superoxide dismutase I", "up-regulation of SOD-1", "positive regulation of superoxide dismutase I", "up-regulation of superoxide dismutase I", "up regulation of superoxide dismutase I", "upregulation of SOD-1", "up regulation of SOD-1"], "types": ["T044"], "canonical_name": "positive regulation of SOD-1"}
{"concept_id": "C3544679", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of SODF"}
{"concept_id": "C3544680", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of SOD-4"}
{"concept_id": "C3544681", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of SOD-3"}
{"concept_id": "C3544682", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of SOD-2"}
{"concept_id": "C3544683", "aliases": ["up regulation of SODS", "upregulation of SODS", "upregulation of superoxide dismutase activity", "upregulation of SOD", "up-regulation of superoxide:superoxide oxidoreductase activity", "positive regulation of superoxide:superoxide oxidoreductase activity", "up-regulation of SODS", "upregulation of superoxide:superoxide oxidoreductase activity", "up regulation of superoxide dismutase activity", "up regulation of SOD", "activation of superoxide:superoxide oxidoreductase activity", "up regulation of superoxide:superoxide oxidoreductase activity", "up-regulation of superoxide dismutase activity", "up-regulation of SOD"], "types": ["T044"], "canonical_name": "positive regulation of superoxide dismutase activity", "definition": "Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity. [GOC:TermGenie]"}
{"concept_id": "C3544684", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of nickel superoxide oxidoreductase"}
{"concept_id": "C3544685", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of nickel superoxide dismutase activity"}
{"concept_id": "C3544686", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of Mn-SOD"}
{"concept_id": "C3544687", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of Mn, Fe superoxide dismutase"}
{"concept_id": "C3544688", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of manganese superoxide oxidoreductase"}
{"concept_id": "C3544689", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of manganese superoxide dismutase activity"}
{"concept_id": "C3544690", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of iron superoxide dismutase activity"}
{"concept_id": "C3544691", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of hepatocuprein"}
{"concept_id": "C3544692", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of hemocuprein"}
{"concept_id": "C3544693", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of ferrisuperoxide dismutase activity"}
{"concept_id": "C3544694", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of Fe-SOD"}
{"concept_id": "C3544695", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of erythrocuprein"}
{"concept_id": "C3544696", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of cytocuprein"}
{"concept_id": "C3544697", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of cuprein"}
{"concept_id": "C3544698", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of Cu-Zn superoxide dismutase activity"}
{"concept_id": "C3544699", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of Cu,Zn-SOD"}
{"concept_id": "C3544700", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of copper, zinc superoxide dismutase activity"}
{"concept_id": "C3544701", "aliases": ["up-regulation of zinc superoxide oxidoreductase"], "types": ["T044"], "canonical_name": "up regulation of zinc superoxide oxidoreductase"}
{"concept_id": "C3544702", "aliases": ["up-regulation of superoxide dismutase II"], "types": ["T044"], "canonical_name": "up regulation of superoxide dismutase II"}
{"concept_id": "C3544703", "aliases": ["up-regulation of SODF"], "types": ["T044"], "canonical_name": "up regulation of SODF"}
{"concept_id": "C3544704", "aliases": ["up-regulation of SOD-4"], "types": ["T044"], "canonical_name": "up regulation of SOD-4"}
{"concept_id": "C3544705", "aliases": ["up-regulation of SOD-3"], "types": ["T044"], "canonical_name": "up regulation of SOD-3"}
{"concept_id": "C3544706", "aliases": ["up-regulation of SOD-2"], "types": ["T044"], "canonical_name": "up regulation of SOD-2"}
{"concept_id": "C3544707", "aliases": ["up-regulation of nickel superoxide oxidoreductase"], "types": ["T044"], "canonical_name": "up regulation of nickel superoxide oxidoreductase"}
{"concept_id": "C3544708", "aliases": ["up-regulation of nickel superoxide dismutase activity"], "types": ["T044"], "canonical_name": "up regulation of nickel superoxide dismutase activity"}
{"concept_id": "C3544709", "aliases": ["up-regulation of manganese superoxide oxidoreductase", "up-regulation of Mn-SOD", "up regulation of Mn-SOD", "up regulation of manganese superoxide oxidoreductase"], "types": ["T044"], "canonical_name": "positive regulation of manganese superoxide oxidoreductase"}
{"concept_id": "C3544710", "aliases": ["up-regulation of Mn, Fe superoxide dismutase"], "types": ["T044"], "canonical_name": "up regulation of Mn, Fe superoxide dismutase"}
{"concept_id": "C3544711", "aliases": ["up-regulation of manganese superoxide dismutase activity"], "types": ["T044"], "canonical_name": "up regulation of manganese superoxide dismutase activity"}
{"concept_id": "C3544712", "aliases": ["up-regulation of iron superoxide oxidoreductase"], "types": ["T044"], "canonical_name": "up regulation of iron superoxide oxidoreductase"}
{"concept_id": "C3544713", "aliases": ["up-regulation of iron superoxide dismutase activity"], "types": ["T044"], "canonical_name": "up regulation of iron superoxide dismutase activity"}
{"concept_id": "C3544714", "aliases": ["up-regulation of hepatocuprein"], "types": ["T044"], "canonical_name": "up regulation of hepatocuprein"}
{"concept_id": "C3544715", "aliases": ["up-regulation of hemocuprein"], "types": ["T044"], "canonical_name": "up regulation of hemocuprein"}
{"concept_id": "C3544716", "aliases": ["up-regulation of ferrisuperoxide dismutase activity"], "types": ["T044"], "canonical_name": "up regulation of ferrisuperoxide dismutase activity"}
{"concept_id": "C3544717", "aliases": ["up-regulation of Fe-SOD"], "types": ["T044"], "canonical_name": "up regulation of Fe-SOD"}
{"concept_id": "C3544718", "aliases": ["up-regulation of erythrocuprein"], "types": ["T044"], "canonical_name": "up regulation of erythrocuprein"}
{"concept_id": "C3544719", "aliases": ["up-regulation of cytocuprein"], "types": ["T044"], "canonical_name": "up regulation of cytocuprein"}
{"concept_id": "C3544720", "aliases": ["up-regulation of cuprein"], "types": ["T044"], "canonical_name": "up regulation of cuprein"}
{"concept_id": "C3544721", "aliases": ["up-regulation of Cu-Zn superoxide dismutase activity"], "types": ["T044"], "canonical_name": "up regulation of Cu-Zn superoxide dismutase activity"}
{"concept_id": "C3544722", "aliases": ["up-regulation of Cu,Zn-SOD"], "types": ["T044"], "canonical_name": "up regulation of Cu,Zn-SOD"}
{"concept_id": "C3544723", "aliases": ["up-regulation of copper, zinc superoxide dismutase activity"], "types": ["T044"], "canonical_name": "up regulation of copper, zinc superoxide dismutase activity"}
{"concept_id": "C3544724", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of zinc superoxide oxidoreductase"}
{"concept_id": "C3544725", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of superoxide dismutase II"}
{"concept_id": "C3544726", "aliases": ["positive regulation of SODS"], "types": ["T044"], "canonical_name": "positive regulation of SOD"}
{"concept_id": "C3544727", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of SODF"}
{"concept_id": "C3544728", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of SOD-4"}
{"concept_id": "C3544729", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of SOD-3"}
{"concept_id": "C3544730", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of SOD-2"}
{"concept_id": "C3544731", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of nickel superoxide oxidoreductase"}
{"concept_id": "C3544732", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of nickel superoxide dismutase activity"}
{"concept_id": "C3544733", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Mn-SOD"}
{"concept_id": "C3544734", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Mn, Fe superoxide dismutase"}
{"concept_id": "C3544735", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of manganese superoxide dismutase activity"}
{"concept_id": "C3544736", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of iron superoxide oxidoreductase"}
{"concept_id": "C3544737", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of iron superoxide dismutase activity"}
{"concept_id": "C3544738", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of hepatocuprein"}
{"concept_id": "C3544739", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of hemocuprein"}
{"concept_id": "C3544740", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ferrisuperoxide dismutase activity"}
{"concept_id": "C3544741", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Fe-SOD"}
{"concept_id": "C3544742", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of erythrocuprein"}
{"concept_id": "C3544743", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cytocuprein"}
{"concept_id": "C3544744", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cuprein"}
{"concept_id": "C3544745", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Cu-Zn superoxide dismutase activity"}
{"concept_id": "C3544746", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Cu,Zn-SOD"}
{"concept_id": "C3544747", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of copper, zinc superoxide dismutase activity"}
{"concept_id": "C3544748", "aliases": [], "types": ["T044"], "canonical_name": "activation of zinc superoxide oxidoreductase"}
{"concept_id": "C3544749", "aliases": [], "types": ["T044"], "canonical_name": "activation of superoxide dismutase II"}
{"concept_id": "C3544750", "aliases": [], "types": ["T044"], "canonical_name": "activation of superoxide dismutase I"}
{"concept_id": "C3544751", "aliases": [], "types": ["T044"], "canonical_name": "activation of superoxide dismutase activity"}
{"concept_id": "C3544752", "aliases": ["activation of SODS"], "types": ["T044"], "canonical_name": "activation of SOD"}
{"concept_id": "C3544753", "aliases": [], "types": ["T044"], "canonical_name": "activation of SODF"}
{"concept_id": "C3544754", "aliases": [], "types": ["T044"], "canonical_name": "activation of SOD-4"}
{"concept_id": "C3544755", "aliases": [], "types": ["T044"], "canonical_name": "activation of SOD-3"}
{"concept_id": "C3544756", "aliases": [], "types": ["T044"], "canonical_name": "activation of SOD-2"}
{"concept_id": "C3544757", "aliases": [], "types": ["T044"], "canonical_name": "activation of SOD-1"}
{"concept_id": "C3544758", "aliases": [], "types": ["T044"], "canonical_name": "activation of nickel superoxide oxidoreductase"}
{"concept_id": "C3544759", "aliases": [], "types": ["T044"], "canonical_name": "activation of nickel superoxide dismutase activity"}
{"concept_id": "C3544760", "aliases": [], "types": ["T044"], "canonical_name": "activation of Mn-SOD"}
{"concept_id": "C3544761", "aliases": [], "types": ["T044"], "canonical_name": "activation of Mn, Fe superoxide dismutase"}
{"concept_id": "C3544762", "aliases": [], "types": ["T044"], "canonical_name": "activation of manganese superoxide oxidoreductase"}
{"concept_id": "C3544763", "aliases": [], "types": ["T044"], "canonical_name": "activation of manganese superoxide dismutase activity"}
{"concept_id": "C3544764", "aliases": [], "types": ["T044"], "canonical_name": "activation of iron superoxide oxidoreductase"}
{"concept_id": "C3544765", "aliases": [], "types": ["T044"], "canonical_name": "activation of iron superoxide dismutase activity"}
{"concept_id": "C3544766", "aliases": [], "types": ["T044"], "canonical_name": "activation of hepatocuprein"}
{"concept_id": "C3544767", "aliases": [], "types": ["T044"], "canonical_name": "activation of hemocuprein"}
{"concept_id": "C3544768", "aliases": [], "types": ["T044"], "canonical_name": "activation of ferrisuperoxide dismutase activity"}
{"concept_id": "C3544769", "aliases": [], "types": ["T044"], "canonical_name": "activation of Fe-SOD"}
{"concept_id": "C3544770", "aliases": [], "types": ["T044"], "canonical_name": "activation of erythrocuprein"}
{"concept_id": "C3544771", "aliases": [], "types": ["T044"], "canonical_name": "activation of cytocuprein"}
{"concept_id": "C3544772", "aliases": [], "types": ["T044"], "canonical_name": "activation of cuprein"}
{"concept_id": "C3544773", "aliases": [], "types": ["T044"], "canonical_name": "activation of Cu-Zn superoxide dismutase activity"}
{"concept_id": "C3544774", "aliases": [], "types": ["T044"], "canonical_name": "activation of Cu,Zn-SOD"}
{"concept_id": "C3544775", "aliases": [], "types": ["T044"], "canonical_name": "activation of copper, zinc superoxide dismutase activity"}
{"concept_id": "C3544776", "aliases": ["negative regulation of erythrocuprein", "down regulation of erythrocuprein", "downregulation of hemocuprein", "down regulation of zinc superoxide oxidoreductase", "inhibition of Cu,Zn-SOD", "down-regulation of cytocuprein", "downregulation of cytocuprein", "down regulation of hepatocuprein", "inhibition of hepatocuprein", "down-regulation of cuprein", "downregulation of Cu,Zn-SOD", "negative regulation of copper, zinc superoxide dismutase activity", "down-regulation of Cu-Zn superoxide dismutase activity", "down regulation of copper, zinc superoxide dismutase activity", "down regulation of Cu,Zn-SOD", "inhibition of zinc superoxide oxidoreductase", "down regulation of Cu-Zn superoxide dismutase activity", "negative regulation of hemocuprein", "down-regulation of hemocuprein", "inhibition of cytocuprein", "down regulation of hemocuprein", "inhibition of erythrocuprein", "inhibition of copper, zinc superoxide dismutase activity", "down-regulation of hepatocuprein", "downregulation of hepatocuprein", "negative regulation of zinc superoxide oxidoreductase", "down-regulation of copper, zinc superoxide dismutase activity", "negative regulation of cytocuprein", "down regulation of cuprein", "negative regulation of hepatocuprein", "downregulation of erythrocuprein", "downregulation of cuprein", "negative regulation of cuprein", "down regulation of cytocuprein", "negative regulation of Cu,Zn-SOD", "inhibition of Cu-Zn superoxide dismutase activity", "down-regulation of Cu,Zn-SOD", "downregulation of Cu-Zn superoxide dismutase activity", "down-regulation of erythrocuprein", "inhibition of cuprein", "negative regulation of Cu-Zn superoxide dismutase activity", "downregulation of zinc superoxide oxidoreductase", "down-regulation of zinc superoxide oxidoreductase", "inhibition of hemocuprein"], "types": ["T044"], "canonical_name": "downregulation of copper, zinc superoxide dismutase activity"}
{"concept_id": "C3544777", "aliases": ["down regulation of SOD-2", "down-regulation of superoxide dismutase II", "down regulation of superoxide dismutase II", "down-regulation of SOD-2", "negative regulation of superoxide dismutase II", "inhibition of SOD-2", "inhibition of superoxide dismutase II", "negative regulation of SOD-2", "downregulation of superoxide dismutase II"], "types": ["T044"], "canonical_name": "downregulation of SOD-2"}
{"concept_id": "C3544778", "aliases": ["down regulation of SODS", "inhibition of superoxide dismutase activity", "inhibition of SODS", "down-regulation of superoxide:superoxide oxidoreductase activity", "negative regulation of superoxide:superoxide oxidoreductase activity", "downregulation of superoxide:superoxide oxidoreductase activity", "inhibition of SOD", "down-regulation of SODS", "inhibition of superoxide:superoxide oxidoreductase activity", "negative regulation of SODS", "down regulation of SOD", "down-regulation of SOD", "down regulation of superoxide:superoxide oxidoreductase activity", "downregulation of superoxide dismutase activity", "down-regulation of superoxide dismutase activity", "negative regulation of SOD", "downregulation of SODS", "downregulation of SOD", "down regulation of superoxide dismutase activity"], "types": ["T044"], "canonical_name": "negative regulation of superoxide dismutase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of superoxide dismutase activity. [GOC:TermGenie]"}
{"concept_id": "C3544779", "aliases": ["down regulation of SODF", "inhibition of SODF", "negative regulation of SODF", "down-regulation of SODF"], "types": ["T044"], "canonical_name": "downregulation of SODF"}
{"concept_id": "C3544780", "aliases": ["negative regulation of SOD-4", "down regulation of SOD-4", "inhibition of SOD-4", "down-regulation of SOD-4"], "types": ["T044"], "canonical_name": "downregulation of SOD-4"}
{"concept_id": "C3544781", "aliases": ["negative regulation of SOD-3", "down-regulation of SOD-3", "down regulation of SOD-3", "inhibition of SOD-3"], "types": ["T044"], "canonical_name": "downregulation of SOD-3"}
{"concept_id": "C3544782", "aliases": ["down regulation of nickel superoxide oxidoreductase", "inhibition of nickel superoxide oxidoreductase", "downregulation of nickel superoxide oxidoreductase", "down regulation of nickel superoxide dismutase activity", "negative regulation of nickel superoxide dismutase activity", "negative regulation of nickel superoxide oxidoreductase", "down-regulation of nickel superoxide dismutase activity", "inhibition of nickel superoxide dismutase activity", "down-regulation of nickel superoxide oxidoreductase"], "types": ["T044"], "canonical_name": "downregulation of nickel superoxide dismutase activity"}
{"concept_id": "C3544783", "aliases": ["regulation of zinc superoxide oxidoreductase", "regulation of hemocuprein", "regulation of cuprein", "regulation of cytocuprein", "regulation of Cu,Zn-SOD", "regulation of Cu-Zn superoxide dismutase activity", "regulation of hepatocuprein", "regulation of erythrocuprein"], "types": ["T044"], "canonical_name": "regulation of copper, zinc superoxide dismutase activity"}
{"concept_id": "C3544784", "aliases": ["regulation of superoxide dismutase II"], "types": ["T044"], "canonical_name": "regulation of SOD-2"}
{"concept_id": "C3544785", "aliases": ["regulation of superoxide dismutase I"], "types": ["T044"], "canonical_name": "regulation of SOD-1"}
{"concept_id": "C3544787", "aliases": [], "types": ["T044"], "canonical_name": "regulation of SODF"}
{"concept_id": "C3544788", "aliases": [], "types": ["T044"], "canonical_name": "regulation of SOD-4"}
{"concept_id": "C3544789", "aliases": [], "types": ["T044"], "canonical_name": "regulation of SOD-3"}
{"concept_id": "C3544790", "aliases": ["regulation of SODS", "regulation of superoxide:superoxide oxidoreductase activity", "regulation of SOD"], "types": ["T044"], "canonical_name": "regulation of superoxide dismutase activity", "definition": "Any process that modulates the frequency, rate or extent of superoxide dismutase activity. [GOC:TermGenie]"}
{"concept_id": "C3544791", "aliases": ["regulation of nickel superoxide oxidoreductase"], "types": ["T044"], "canonical_name": "regulation of nickel superoxide dismutase activity"}
{"concept_id": "C3544792", "aliases": ["regulation of Mn, Fe superoxide dismutase", "regulation of manganese superoxide dismutase activity", "regulation of Mn-SOD", "regulation of manganese superoxide oxidoreductase", "regulation of iron superoxide oxidoreductase", "regulation of iron superoxide dismutase activity", "regulation of Fe-SOD"], "types": ["T044"], "canonical_name": "regulation of ferrisuperoxide dismutase activity"}
{"concept_id": "C3544793", "aliases": ["down regulation of satellite cell activation involved in skeletal muscle regeneration", "downregulation of satellite cell activation involved in skeletal muscle regeneration", "inhibition of satellite cell activation involved in skeletal muscle regeneration", "down-regulation of satellite cell activation involved in skeletal muscle regeneration"], "types": ["T043"], "canonical_name": "negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell activation involved in skeletal muscle regeneration. [GOC:dph, GOC:TermGenie, PMID:21272575]"}
{"concept_id": "C3544794", "aliases": ["positive regulation of poly(ADP-ribose) synthase activity", "upregulation of NAD+ ADP-ribosyltransferase activity", "up regulation of ADP-ribosyltransferase (polymerizing) activity", "up regulation of poly(ADP-ribose) synthetase activity", "up-regulation of ADP-ribosyltransferase (polymerizing) activity", "up-regulation of poly(ADP-ribose) synthetase activity", "activation of poly(ADP-ribose)polymerase activity", "positive regulation of poly(ADP-ribose)polymerase activity", "positive regulation of poly(adenosine diphosphate ribose) polymerase activity", "up-regulation of poly(ADP-ribose)polymerase activity", "positive regulation of NAD ADP-ribosyltransferase activity", "up regulation of NAD+ ADP-ribosyltransferase activity", "activation of poly(adenosine diphosphate ribose) polymerase activity", "upregulation of poly(adenosine diphosphate ribose) polymerase activity", "upregulation of NAD ADP-ribosyltransferase activity", "upregulation of poly(ADP-ribose) synthetase activity", "activation of NAD+ ADP-ribosyltransferase activity", "up-regulation of NAD ADP-ribosyltransferase activity", "up regulation of poly(ADP-ribose) synthase activity", "up-regulation of poly(adenosine diphosphate ribose) polymerase activity", "up-regulation of NAD+ ADP-ribosyltransferase activity", "up-regulation of poly(ADP-ribose) synthase activity", "up regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "upregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "activation of poly(ADP-ribose) synthase activity", "activation of poly(ADP-ribose) synthetase activity", "activation of NAD ADP-ribosyltransferase activity", "positive regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "up regulation of poly(ADP-ribose)polymerase activity", "activation of ADP-ribosyltransferase (polymerizing) activity", "positive regulation of ADP-ribosyltransferase (polymerizing) activity", "activation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "up regulation of NAD ADP-ribosyltransferase activity", "positive regulation of poly(ADP-ribose) synthetase activity", "up-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "upregulation of poly(ADP-ribose)polymerase activity", "upregulation of poly(ADP-ribose) synthase activity", "up regulation of poly(adenosine diphosphate ribose) polymerase activity", "upregulation of ADP-ribosyltransferase (polymerizing) activity"], "types": ["T044"], "canonical_name": "positive regulation of NAD+ ADP-ribosyltransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3544795", "aliases": ["inhibition of NAD ADP-ribosyltransferase activity", "inhibition of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "inhibition of poly(ADP-ribose)polymerase activity", "down-regulation of poly(ADP-ribose)polymerase activity", "downregulation of poly(adenosine diphosphate ribose) polymerase activity", "negative regulation of poly(ADP-ribose)polymerase activity", "downregulation of poly(ADP-ribose)polymerase activity", "down regulation of poly(ADP-ribose)polymerase activity", "down regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "down regulation of poly(ADP-ribose) synthase activity", "down regulation of NAD+ ADP-ribosyltransferase activity", "down regulation of NAD ADP-ribosyltransferase activity", "negative regulation of ADP-ribosyltransferase (polymerizing) activity", "downregulation of poly(ADP-ribose) synthase activity", "negative regulation of poly(ADP-ribose) synthetase activity", "down-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "inhibition of ADP-ribosyltransferase (polymerizing) activity", "inhibition of poly(ADP-ribose) synthetase activity", "downregulation of poly(ADP-ribose) synthetase activity", "downregulation of NAD ADP-ribosyltransferase activity", "negative regulation of poly(ADP-ribose) synthase activity", "negative regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "inhibition of poly(adenosine diphosphate ribose) polymerase activity", "down regulation of poly(ADP-ribose) synthetase activity", "downregulation of ADP-ribosyltransferase (polymerizing) activity", "down-regulation of ADP-ribosyltransferase (polymerizing) activity", "inhibition of poly(ADP-ribose) synthase activity", "down regulation of poly(adenosine diphosphate ribose) polymerase activity", "negative regulation of NAD ADP-ribosyltransferase activity", "down-regulation of poly(ADP-ribose) synthase activity", "downregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "negative regulation of poly(adenosine diphosphate ribose) polymerase activity", "inhibition of NAD+ ADP-ribosyltransferase activity", "down-regulation of poly(adenosine diphosphate ribose) polymerase activity", "downregulation of NAD+ ADP-ribosyltransferase activity", "down-regulation of NAD ADP-ribosyltransferase activity", "down regulation of ADP-ribosyltransferase (polymerizing) activity", "down-regulation of poly(ADP-ribose) synthetase activity", "down-regulation of NAD+ ADP-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "negative regulation of NAD+ ADP-ribosyltransferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3544796", "aliases": ["up regulation of contractile ring localization involved in cell cycle cytokinesis", "upregulation of contractile ring localisation involved in cell cycle cytokinesis", "up regulation of actomyosin contractile ring localization", "positive regulation of contractile ring localization involved in cell cycle cytokinesis", "activation of contractile ring localization involved in cell cycle cytokinesis", "up-regulation of actomyosin contractile ring localization", "up-regulation of contractile ring localization involved in cell cycle cytokinesis", "activation of contractile ring localisation involved in cell cycle cytokinesis", "upregulation of actomyosin contractile ring localization", "upregulation of contractile ring localization involved in cell cycle cytokinesis", "positive regulation of contractile ring localisation involved in cell cycle cytokinesis", "activation of actomyosin contractile ring localization", "up regulation of contractile ring localisation involved in cell cycle cytokinesis", "up-regulation of contractile ring localisation involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "positive regulation of actomyosin contractile ring localization", "definition": "Any process that activates or increases the frequency, rate or extent of actomyosin contractile ring localization. [GOC:TermGenie]"}
{"concept_id": "C3544797", "aliases": ["inhibition of contractile ring localisation involved in cell cycle cytokinesis", "downregulation of contractile ring localization involved in cell cycle cytokinesis", "down-regulation of contractile ring localization involved in cell cycle cytokinesis", "inhibition of actomyosin contractile ring localization", "down-regulation of contractile ring localisation involved in cell cycle cytokinesis", "negative regulation of contractile ring localization involved in cell cycle cytokinesis", "down regulation of contractile ring localization involved in cell cycle cytokinesis", "inhibition of contractile ring localization involved in cell cycle cytokinesis", "negative regulation of contractile ring localisation involved in cell cycle cytokinesis", "down-regulation of actomyosin contractile ring localization", "down regulation of actomyosin contractile ring localization", "down regulation of contractile ring localisation involved in cell cycle cytokinesis", "downregulation of actomyosin contractile ring localization", "downregulation of contractile ring localisation involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "negative regulation of actomyosin contractile ring localization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of actomyosin contractile ring localization. [GOC:TermGenie]"}
{"concept_id": "C3544798", "aliases": [], "types": ["T043"], "canonical_name": "activation of synoviocyte proliferation"}
{"concept_id": "C3544799", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synoviocyte proliferation"}
{"concept_id": "C3544801", "aliases": ["up regulation of synaptic vesicle membrane organization and biogenesis", "up-regulation of synaptic vesicle membrane organization and biogenesis"], "types": ["T043"], "canonical_name": "upregulation of synaptic vesicle membrane organization and biogenesis"}
{"concept_id": "C3544802", "aliases": ["up regulation of SLMV biogenesis", "up-regulation of SLMV biogenesis"], "types": ["T043"], "canonical_name": "upregulation of SLMV biogenesis"}
{"concept_id": "C3544803", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle membrane organization and biogenesis"}
{"concept_id": "C3544804", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of SLMV biogenesis"}
{"concept_id": "C3544805", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptic vesicle membrane organization and biogenesis"}
{"concept_id": "C3544806", "aliases": ["activation of synaptic vesicle membrane organization"], "types": ["T043"], "canonical_name": "activation of synaptic vesicle membrane organisation"}
{"concept_id": "C3544807", "aliases": [], "types": ["T043"], "canonical_name": "activation of SLMV biogenesis"}
{"concept_id": "C3544808", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle membrane organization and biogenesis"}
{"concept_id": "C3544809", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of SLMV biogenesis"}
{"concept_id": "C3544810", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synaptic vesicle membrane organization and biogenesis"}
{"concept_id": "C3544811", "aliases": ["inhibition of synaptic vesicle membrane organization"], "types": ["T043"], "canonical_name": "inhibition of synaptic vesicle membrane organisation"}
{"concept_id": "C3544812", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of SLMV biogenesis"}
{"concept_id": "C3544813", "aliases": ["down regulation of synaptic vesicle membrane organization and biogenesis", "down-regulation of synaptic vesicle membrane organization and biogenesis"], "types": ["T043"], "canonical_name": "downregulation of synaptic vesicle membrane organization and biogenesis"}
{"concept_id": "C3544814", "aliases": ["down-regulation of SLMV biogenesis", "down regulation of SLMV biogenesis"], "types": ["T043"], "canonical_name": "downregulation of SLMV biogenesis"}
{"concept_id": "C3544815", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle membrane organization and biogenesis"}
{"concept_id": "C3544816", "aliases": [], "types": ["T043"], "canonical_name": "regulation of SLMV biogenesis"}
{"concept_id": "C3544817", "aliases": ["activation of presynaptic membrane organization"], "types": ["T043"], "canonical_name": "activation of presynaptic membrane organisation"}
{"concept_id": "C3544818", "aliases": ["inhibition of presynaptic membrane organization"], "types": ["T043"], "canonical_name": "inhibition of presynaptic membrane organisation"}
{"concept_id": "C3544819", "aliases": ["activation of postsynaptic membrane organization"], "types": ["T043"], "canonical_name": "activation of postsynaptic membrane organisation"}
{"concept_id": "C3544820", "aliases": ["inhibition of postsynaptic membrane organization"], "types": ["T043"], "canonical_name": "inhibition of postsynaptic membrane organisation"}
{"concept_id": "C3544821", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lymphocyte chemotaxis"}
{"concept_id": "C3544822", "aliases": ["activation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning"], "types": ["T044"], "canonical_name": "activation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning"}
{"concept_id": "C3544823", "aliases": ["activation of hh signaling pathway involved in dorsal/ventral neural tube patterning"], "types": ["T044"], "canonical_name": "activation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning"}
{"concept_id": "C3544824", "aliases": ["inhibition of smoothened signalling pathway involved in dorsal/ventral neural tube patterning"], "types": ["T044"], "canonical_name": "inhibition of smoothened signaling pathway involved in dorsal/ventral neural tube patterning"}
{"concept_id": "C3544825", "aliases": ["inhibition of hh signaling pathway involved in dorsal/ventral neural tube patterning"], "types": ["T044"], "canonical_name": "inhibition of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning"}
{"concept_id": "C3544826", "aliases": ["activation of terminal button organisation", "activation of terminal button organization"], "types": ["T043"], "canonical_name": "activation of terminal bouton organization"}
{"concept_id": "C3544827", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptic bouton organization"}
{"concept_id": "C3544828", "aliases": [], "types": ["T043"], "canonical_name": "activation of presynaptic bouton organization"}
{"concept_id": "C3544829", "aliases": [], "types": ["T043"], "canonical_name": "activation of bouton organization"}
{"concept_id": "C3544830", "aliases": ["inhibition of presynaptic bouton organization", "inhibition of terminal bouton organization", "inhibition of terminal button organization", "inhibition of terminal button organisation", "inhibition of synaptic bouton organization"], "types": ["T043"], "canonical_name": "inhibition of bouton organization"}
{"concept_id": "C3544831", "aliases": [], "types": ["T043"], "canonical_name": "activation of vesicle transport along microtubule"}
{"concept_id": "C3544832", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vesicle transport along microtubule"}
{"concept_id": "C3544833", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of double-strand break repair via break-induced replication"}
{"concept_id": "C3544834", "aliases": [], "types": ["T038"], "canonical_name": "activation of acid-sensing ion channel activity"}
{"concept_id": "C3544835", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acid-sensing ion channel activity"}
{"concept_id": "C3544836", "aliases": ["positive regulation of telomeric RNA transcription from Pol II promoter", "up regulation of telomeric RNA transcription from Pol II promoter", "up-regulation of telomeric RNA transcription from Pol II promoter", "upregulation of telomeric RNA transcription from Pol II promoter", "upregulation of telomeric RNA transcription from RNA pol II promoter", "up-regulation of telomeric RNA transcription from RNA pol II promoter", "up regulation of telomeric RNA transcription from RNA pol II promoter", "activation of telomeric RNA transcription from RNA pol II promoter", "activation of telomeric RNA transcription from Pol II promoter"], "types": ["T045"], "canonical_name": "positive regulation of telomeric RNA transcription from RNA pol II promoter", "definition": "Any process that activates or increases the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter. [GOC:TermGenie]"}
{"concept_id": "C3544837", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomeric RNA transcription from RNA pol II promoter"}
{"concept_id": "C3544838", "aliases": ["up regulation of alkane anabolism", "up regulation of alkane biosynthetic process", "activation of alkane anabolism", "up regulation of alkane synthesis", "activation of alkane formation", "activation of alkane biosynthetic process", "upregulation of alkane biosynthesis", "upregulation of alkane anabolism", "up regulation of alkane biosynthesis", "positive regulation of alkane formation", "up regulation of alkane formation", "activation of alkane synthesis", "upregulation of alkane synthesis", "up-regulation of alkane formation", "activation of alkane biosynthesis", "up-regulation of alkane anabolism", "positive regulation of alkane synthesis", "up-regulation of alkane biosynthesis", "positive regulation of alkane biosynthesis", "upregulation of alkane biosynthetic process", "up-regulation of alkane biosynthetic process", "positive regulation of alkane anabolism", "up-regulation of alkane synthesis", "upregulation of alkane formation"], "types": ["T044"], "canonical_name": "positive regulation of alkane biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of alkane biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3544839", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of alkane biosynthetic process"}
{"concept_id": "C3544840", "aliases": [], "types": ["T043"], "canonical_name": "activation of endothelial cell development"}
{"concept_id": "C3544841", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelial cell development"}
{"concept_id": "C3544842", "aliases": [], "types": ["T039"], "canonical_name": "activation of synaptic vesicle lumen pH reduction"}
{"concept_id": "C3544843", "aliases": [], "types": ["T039"], "canonical_name": "activation of synaptic vesicle lumen acidification"}
{"concept_id": "C3544844", "aliases": ["inhibition of synaptic vesicle lumen pH reduction"], "types": ["T039"], "canonical_name": "inhibition of synaptic vesicle lumen acidification"}
{"concept_id": "C3544845", "aliases": ["activation of ent-pimara-8(14),15-diene biosynthesis", "activation of ent-pimara-8(14),15-diene synthesis", "activation of ent-pimara-8(14),15-diene formation", "activation of ent-pimara-8(14),15-diene biosynthetic process"], "types": ["T044"], "canonical_name": "activation of ent-pimara-8(14),15-diene anabolism"}
{"concept_id": "C3544846", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ent-pimara-8(14),15-diene synthesis"}
{"concept_id": "C3544847", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ent-pimara-8(14),15-diene formation"}
{"concept_id": "C3544848", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ent-pimara-8(14),15-diene biosynthetic process"}
{"concept_id": "C3544849", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ent-pimara-8(14),15-diene biosynthesis"}
{"concept_id": "C3544850", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ent-pimara-8(14),15-diene anabolism"}
{"concept_id": "C3544851", "aliases": ["DNA methylation or demethylation involved in embryogenesis", "changes in DNA methylation involved in embryonal development", "DNA methylation or demethylation involved in embryonal development", "changes in DNA methylation involved in embryo development", "changes in DNA methylation involved in embryogenesis"], "types": ["T045"], "canonical_name": "changes to DNA methylation involved in embryo development", "definition": "The addition or removal of methyl groups to DNA that contributes to the epigenetic regulation of embryonic gene expression. [GOC:TermGenie]"}
{"concept_id": "C3544852", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA demethylation"}
{"concept_id": "C3544853", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA demethylation"}
{"concept_id": "C3544854", "aliases": ["up regulation of haematopoietic progenitor cell differentiation", "activation of haemopoietic progenitor cell differentiation", "upregulation of hemopoietic progenitor cell differentiation", "up-regulation of hematopoietic progenitor cell differentiation", "positive regulation of hemopoietic progenitor cell differentiation", "up-regulation of haematopoietic progenitor cell differentiation", "positive regulation of haemopoietic progenitor cell differentiation", "upregulation of hematopoietic progenitor cell differentiation", "upregulation of haemopoietic progenitor cell differentiation", "up-regulation of hemopoietic progenitor cell differentiation", "up-regulation of haemopoietic progenitor cell differentiation", "activation of haematopoietic progenitor cell differentiation", "positive regulation of haematopoietic progenitor cell differentiation", "activation of hematopoietic progenitor cell differentiation", "up regulation of hemopoietic progenitor cell differentiation", "up regulation of haemopoietic progenitor cell differentiation", "up regulation of hematopoietic progenitor cell differentiation", "activation of hemopoietic progenitor cell differentiation", "upregulation of haematopoietic progenitor cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of hematopoietic progenitor cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. [GOC:BHF, GOC:rl, GOC:TermGenie]"}
{"concept_id": "C3544857", "aliases": ["downregulation of haematopoietic progenitor cell differentiation", "inhibition of haematopoietic progenitor cell differentiation", "down-regulation of hematopoietic progenitor cell differentiation", "down-regulation of haemopoietic progenitor cell differentiation", "down-regulation of hemopoietic progenitor cell differentiation", "inhibition of hematopoietic progenitor cell differentiation", "negative regulation of haemopoietic progenitor cell differentiation", "down regulation of haematopoietic progenitor cell differentiation", "downregulation of hemopoietic progenitor cell differentiation", "down regulation of haemopoietic progenitor cell differentiation", "inhibition of hemopoietic progenitor cell differentiation", "negative regulation of hemopoietic progenitor cell differentiation", "downregulation of hematopoietic progenitor cell differentiation", "inhibition of haemopoietic progenitor cell differentiation", "down-regulation of haematopoietic progenitor cell differentiation", "negative regulation of haematopoietic progenitor cell differentiation", "down regulation of hematopoietic progenitor cell differentiation", "down regulation of hemopoietic progenitor cell differentiation", "downregulation of haemopoietic progenitor cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of hematopoietic progenitor cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. [GOC:BHF, GOC:rl, GOC:TermGenie]"}
{"concept_id": "C3544858", "aliases": [], "types": ["T039"], "canonical_name": "activation of anion channel activity"}
{"concept_id": "C3544859", "aliases": [], "types": ["T043"], "canonical_name": "activation of macromitophagy"}
{"concept_id": "C3544860", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of macromitophagy"}
{"concept_id": "C3544861", "aliases": ["up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus", "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus"], "types": ["T045"], "canonical_name": "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus"}
{"concept_id": "C3544862", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus"}
{"concept_id": "C3544863", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of global transcription from Pol II promoter involved in cellular response to chemical stimulus"}
{"concept_id": "C3544864", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus"}
{"concept_id": "C3544865", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus"}
{"concept_id": "C3544866", "aliases": [], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus"}
{"concept_id": "C3544867", "aliases": [], "types": ["T044"], "canonical_name": "activation of glyceride transport"}
{"concept_id": "C3544868", "aliases": [], "types": ["T044"], "canonical_name": "activation of acylglycerol transport"}
{"concept_id": "C3544869", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glyceride transport"}
{"concept_id": "C3544870", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acylglycerol transport"}
{"concept_id": "C3544871", "aliases": [], "types": ["T044"], "canonical_name": "activation of cysteine metabolism"}
{"concept_id": "C3544872", "aliases": [], "types": ["T044"], "canonical_name": "activation of cysteine metabolic process"}
{"concept_id": "C3544873", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cysteine metabolism"}
{"concept_id": "C3544874", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cysteine metabolic process"}
{"concept_id": "C3544875", "aliases": [], "types": ["T039"], "canonical_name": "activation of lymphangiogenesis"}
{"concept_id": "C3544876", "aliases": [], "types": ["T039"], "canonical_name": "activation of lymph vessel formation"}
{"concept_id": "C3544877", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of lymphangiogenesis"}
{"concept_id": "C3544878", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of lymph vessel formation"}
{"concept_id": "C3544887", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription factor catabolic process"}
{"concept_id": "C3544888", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription factor catabolic process"}
{"concept_id": "C3544889", "aliases": [], "types": ["T044"], "canonical_name": "activation of syringal lignin catabolic process"}
{"concept_id": "C3544890", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of syringal lignin catabolic process"}
{"concept_id": "C3544891", "aliases": [], "types": ["T044"], "canonical_name": "activation of ferulate catabolic process"}
{"concept_id": "C3544892", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ferulate catabolic process"}
{"concept_id": "C3544893", "aliases": ["up regulation of tetrapyrrole biosynthesis", "positive regulation of tetrapyrrole synthesis", "activation of tetrapyrrole biosynthetic process", "up-regulation of tetrapyrrole formation", "up regulation of tetrapyrrole anabolism", "up regulation of tetrapyrrole biosynthetic process", "up-regulation of tetrapyrrole synthesis", "up-regulation of tetrapyrrole biosynthetic process", "upregulation of tetrapyrrole synthesis", "up regulation of tetrapyrrole synthesis", "up-regulation of tetrapyrrole anabolism", "activation of tetrapyrrole biosynthesis", "activation of tetrapyrrole anabolism", "positive regulation of tetrapyrrole biosynthesis", "up regulation of tetrapyrrole formation", "upregulation of tetrapyrrole formation", "upregulation of tetrapyrrole biosynthesis", "activation of tetrapyrrole synthesis", "positive regulation of tetrapyrrole formation", "activation of tetrapyrrole formation", "upregulation of tetrapyrrole biosynthetic process", "positive regulation of tetrapyrrole anabolism", "upregulation of tetrapyrrole anabolism", "up-regulation of tetrapyrrole biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of tetrapyrrole biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3544894", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tetrapyrrole biosynthetic process"}
{"concept_id": "C3544895", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to formic acid"}
{"concept_id": "C3544896", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to formic acid"}
{"concept_id": "C3544897", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to acetate"}
{"concept_id": "C3544898", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to acetate"}
{"concept_id": "C3544899", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to toluene"}
{"concept_id": "C3544900", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to toluene"}
{"concept_id": "C3544901", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to benzene"}
{"concept_id": "C3544902", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to benzene"}
{"concept_id": "C3544903", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to butan-1-ol"}
{"concept_id": "C3544904", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to butan-1-ol"}
{"concept_id": "C3544905", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to propan-1-ol"}
{"concept_id": "C3544906", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to propan-1-ol"}
{"concept_id": "C3544907", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to furfural"}
{"concept_id": "C3544908", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to furfural"}
{"concept_id": "C3544909", "aliases": [], "types": ["T044"], "canonical_name": "activation of toluene metabolic process"}
{"concept_id": "C3544910", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of toluene metabolic process"}
{"concept_id": "C3544911", "aliases": [], "types": ["T044"], "canonical_name": "activation of toluene catabolic process"}
{"concept_id": "C3544912", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of toluene catabolic process"}
{"concept_id": "C3544913", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to cycloalkane"}
{"concept_id": "C3544914", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to cycloalkane"}
{"concept_id": "C3544915", "aliases": ["up-regulation of syringal lignin anabolism", "up regulation of syringal lignin synthesis", "activation of S-lignin biosynthetic process", "positive regulation of syringal lignin anabolism", "upregulation of syringal lignin biosynthetic process", "positive regulation of S-lignin biosynthetic process", "upregulation of syringal lignin synthesis", "positive regulation of syringal lignin synthesis", "upregulation of syringal lignin anabolism", "up regulation of S-lignin biosynthetic process", "activation of syringal lignin biosynthesis", "up regulation of syringal lignin formation", "upregulation of syringal lignin formation", "activation of syringal lignin anabolism", "activation of syringal lignin biosynthetic process", "up regulation of syringal lignin biosynthesis", "activation of syringal lignin synthesis", "upregulation of S-lignin biosynthetic process", "up-regulation of syringal lignin biosynthetic process", "upregulation of syringal lignin biosynthesis", "up regulation of syringal lignin anabolism", "positive regulation of syringal lignin formation", "up-regulation of syringal lignin biosynthesis", "up-regulation of S-lignin biosynthetic process", "up-regulation of syringal lignin formation", "up-regulation of syringal lignin synthesis", "activation of syringal lignin formation", "up regulation of syringal lignin biosynthetic process", "positive regulation of syringal lignin biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of syringal lignin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of syringal lignin biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3544916", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of syringal lignin biosynthetic process"}
{"concept_id": "C3544917", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to alcohol"}
{"concept_id": "C3544918", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to alcohol"}
{"concept_id": "C3544919", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to ethanol"}
{"concept_id": "C3544920", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to ethanol"}
{"concept_id": "C3544921", "aliases": [], "types": ["T040"], "canonical_name": "activation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA"}
{"concept_id": "C3544922", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tetrapyrrole biosynthetic process from glycine and succinyl-CoA"}
{"concept_id": "C3544923", "aliases": [], "types": ["T044"], "canonical_name": "activation of tetrapyrrole biosynthetic process from glutamate"}
{"concept_id": "C3544924", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tetrapyrrole biosynthetic process from glutamate"}
{"concept_id": "C3544925", "aliases": [], "types": ["T045"], "canonical_name": "activation of phosphorylation of RNA polymerase II C-terminal domain"}
{"concept_id": "C3544926", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of phosphorylation of RNA polymerase II C-terminal domain"}
{"concept_id": "C3544927", "aliases": [], "types": ["T044"], "canonical_name": "activation of tetrapyrrole catabolic process"}
{"concept_id": "C3544928", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tetrapyrrole catabolic process"}
{"concept_id": "C3544929", "aliases": [], "types": ["T044"], "canonical_name": "activation of tetrapyrrole metabolic process"}
{"concept_id": "C3544930", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tetrapyrrole metabolic process"}
{"concept_id": "C3544931", "aliases": [], "types": ["T044"], "canonical_name": "activation of transforming growth factor beta3 activation"}
{"concept_id": "C3544932", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of transforming growth factor beta3 activation"}
{"concept_id": "C3544933", "aliases": [], "types": ["T044"], "canonical_name": "activation of transforming growth factor beta2 activation"}
{"concept_id": "C3544934", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of transforming growth factor beta2 activation"}
{"concept_id": "C3544937", "aliases": [], "types": ["T044"], "canonical_name": "activation of transforming growth factor beta activation"}
{"concept_id": "C3544938", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of transforming growth factor beta activation"}
{"concept_id": "C3544939", "aliases": ["up regulation of dihydropyridine-sensitive calcium channel activity", "up-regulation of dihydropyridine-sensitive calcium channel activity"], "types": ["T044"], "canonical_name": "upregulation of dihydropyridine-sensitive calcium channel activity"}
{"concept_id": "C3544940", "aliases": ["up regulation of depolarization-activated calcium channel", "up-regulation of depolarization-activated calcium channel"], "types": ["T044"], "canonical_name": "upregulation of depolarization-activated calcium channel"}
{"concept_id": "C3544941", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of dihydropyridine-sensitive calcium channel activity"}
{"concept_id": "C3544942", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of depolarization-activated calcium channel"}
{"concept_id": "C3544944", "aliases": [], "types": ["T038"], "canonical_name": "activation of dihydropyridine-sensitive calcium channel activity"}
{"concept_id": "C3544945", "aliases": [], "types": ["T038"], "canonical_name": "activation of depolarization-activated calcium channel"}
{"concept_id": "C3544946", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of dihydropyridine-sensitive calcium channel activity"}
{"concept_id": "C3544947", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of depolarization-activated calcium channel"}
{"concept_id": "C3544949", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of dihydropyridine-sensitive calcium channel activity"}
{"concept_id": "C3544950", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of depolarization-activated calcium channel"}
{"concept_id": "C3544951", "aliases": ["down-regulation of dihydropyridine-sensitive calcium channel activity", "down regulation of dihydropyridine-sensitive calcium channel activity"], "types": ["T044"], "canonical_name": "downregulation of dihydropyridine-sensitive calcium channel activity"}
{"concept_id": "C3544952", "aliases": ["down regulation of depolarization-activated calcium channel", "down-regulation of depolarization-activated calcium channel"], "types": ["T044"], "canonical_name": "downregulation of depolarization-activated calcium channel"}
{"concept_id": "C3544953", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dihydropyridine-sensitive calcium channel activity"}
{"concept_id": "C3544954", "aliases": [], "types": ["T044"], "canonical_name": "regulation of depolarization-activated calcium channel"}
{"concept_id": "C3544955", "aliases": [], "types": ["T043"], "canonical_name": "activation of chorionic trophoblast cell proliferation"}
{"concept_id": "C3544956", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chorionic trophoblast cell proliferation"}
{"concept_id": "C3544957", "aliases": [], "types": ["T043"], "canonical_name": "activation of potassium ion transmembrane transport"}
{"concept_id": "C3544958", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of potassium ion transmembrane transport"}
{"concept_id": "C3544959", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylglycerol synthesis"}
{"concept_id": "C3544960", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylglycerol formation"}
{"concept_id": "C3544961", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylglycerol biosynthetic process"}
{"concept_id": "C3544962", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylglycerol biosynthesis"}
{"concept_id": "C3544963", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylglycerol anabolism"}
{"concept_id": "C3544964", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylglycerol synthesis"}
{"concept_id": "C3544965", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylglycerol formation"}
{"concept_id": "C3544966", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylglycerol biosynthetic process"}
{"concept_id": "C3544967", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylglycerol biosynthesis"}
{"concept_id": "C3544968", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylglycerol anabolism"}
{"concept_id": "C3544970", "aliases": ["up-regulation of secondary cell wall synthesis", "up regulation of secondary cell wall synthesis"], "types": ["T043"], "canonical_name": "upregulation of secondary cell wall synthesis"}
{"concept_id": "C3544971", "aliases": ["up regulation of secondary cell wall formation", "up-regulation of secondary cell wall formation"], "types": ["T043"], "canonical_name": "upregulation of secondary cell wall formation"}
{"concept_id": "C3544972", "aliases": ["up-regulation of secondary cell wall biosynthetic process", "up regulation of secondary cell wall biosynthetic process"], "types": ["T043"], "canonical_name": "upregulation of secondary cell wall biosynthetic process"}
{"concept_id": "C3544973", "aliases": ["up regulation of secondary cell wall anabolism", "up-regulation of secondary cell wall anabolism"], "types": ["T043"], "canonical_name": "upregulation of secondary cell wall anabolism"}
{"concept_id": "C3544974", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of secondary cell wall synthesis"}
{"concept_id": "C3544975", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of secondary cell wall formation"}
{"concept_id": "C3544976", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of secondary cell wall biosynthetic process"}
{"concept_id": "C3544977", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of secondary cell wall anabolism"}
{"concept_id": "C3544978", "aliases": [], "types": ["T043"], "canonical_name": "activation of secondary cell wall synthesis"}
{"concept_id": "C3544979", "aliases": [], "types": ["T043"], "canonical_name": "activation of secondary cell wall formation"}
{"concept_id": "C3544980", "aliases": [], "types": ["T043"], "canonical_name": "activation of secondary cell wall biosynthetic process"}
{"concept_id": "C3544981", "aliases": [], "types": ["T043"], "canonical_name": "activation of secondary cell wall biogenesis"}
{"concept_id": "C3544982", "aliases": [], "types": ["T043"], "canonical_name": "activation of secondary cell wall anabolism"}
{"concept_id": "C3544983", "aliases": ["down regulation of secondary cell wall formation", "down regulation of secondary cell wall biogenesis", "negative regulation of secondary cell wall synthesis", "negative regulation of plant-type secondary cell wall biogenesis", "down-regulation of cellulose and pectin-containing secondary cell wall biogenesis", "negative regulation of secondary cell wall anabolism", "down regulation of secondary cell wall synthesis", "down regulation of secondary cell wall anabolism", "down-regulation of secondary cell wall biosynthetic process", "downregulation of plant-type secondary cell wall biogenesis", "negative regulation of secondary cell wall biosynthetic process", "down-regulation of secondary cell wall anabolism", "downregulation of secondary cell wall anabolism", "downregulation of secondary cell wall synthesis", "down-regulation of plant-type secondary cell wall biogenesis", "downregulation of secondary cell wall biosynthetic process", "downregulation of secondary cell wall biogenesis", "inhibition of plant-type secondary cell wall biogenesis", "down regulation of secondary cell wall biosynthetic process", "downregulation of secondary cell wall formation", "inhibition of cellulose and pectin-containing secondary cell wall biogenesis", "down-regulation of secondary cell wall formation", "negative regulation of cellulose and pectin-containing secondary cell wall biogenesis", "down-regulation of secondary cell wall synthesis", "down regulation of plant-type secondary cell wall biogenesis", "down regulation of cellulose and pectin-containing secondary cell wall biogenesis", "down-regulation of secondary cell wall biogenesis", "downregulation of cellulose and pectin-containing secondary cell wall biogenesis", "negative regulation of secondary cell wall formation"], "types": ["T043"], "canonical_name": "negative regulation of secondary cell wall biogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell wall biogenesis. [GOC:TermGenie]"}
{"concept_id": "C3544984", "aliases": ["inhibition of secondary cell wall biosynthetic process", "inhibition of secondary cell wall synthesis", "inhibition of secondary cell wall formation", "inhibition of secondary cell wall biogenesis"], "types": ["T043"], "canonical_name": "inhibition of secondary cell wall anabolism"}
{"concept_id": "C3544985", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of vascular system development involved in avascular cornea development in camera-type eye"}
{"concept_id": "C3544986", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of vascular system development involved in avascular cornea development"}
{"concept_id": "C3544987", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of vasculature development involved in avascular cornea development in camera-type eye"}
{"concept_id": "C3544988", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of vasculature development involved in avascular cornea development"}
{"concept_id": "C3544989", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of vascular system development involved in avascular cornea development in camera-type eye"}
{"concept_id": "C3544990", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of vascular system development involved in avascular cornea development"}
{"concept_id": "C3544991", "aliases": ["down-regulation of vascular system development involved in avascular cornea development in camera-type eye", "down regulation of vascular system development involved in avascular cornea development in camera-type eye"], "types": ["T042"], "canonical_name": "downregulation of vascular system development involved in avascular cornea development in camera-type eye"}
{"concept_id": "C3544992", "aliases": ["down regulation of vascular system development involved in avascular cornea development", "down-regulation of vascular system development involved in avascular cornea development"], "types": ["T042"], "canonical_name": "downregulation of vascular system development involved in avascular cornea development"}
{"concept_id": "C3544993", "aliases": [], "types": ["T043"], "canonical_name": "response to thialysine"}
{"concept_id": "C3544994", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of vascular system development"}
{"concept_id": "C3544995", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of vasculature development"}
{"concept_id": "C3544996", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of vascular system development"}
{"concept_id": "C3544997", "aliases": ["down regulation of vascular system development", "down-regulation of vascular system development"], "types": ["T039"], "canonical_name": "downregulation of vascular system development"}
{"concept_id": "C3544998", "aliases": [], "types": ["T039"], "canonical_name": "regulation of vascular system development"}
{"concept_id": "C3544999", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of store-operated calcium channel activity"}
{"concept_id": "C3545000", "aliases": [], "types": ["T039"], "canonical_name": "activation of lateral root development"}
{"concept_id": "C3545001", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of lateral root development"}
{"concept_id": "C3545002", "aliases": [], "types": ["T043"], "canonical_name": "activation of odontoblast differentiation"}
{"concept_id": "C3545003", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of odontoblast differentiation"}
{"concept_id": "C3545004", "aliases": [], "types": ["T043"], "canonical_name": "activation of heart induction"}
{"concept_id": "C3545005", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of heart induction"}
{"concept_id": "C3545006", "aliases": [], "types": ["T044"], "canonical_name": "activation of trehalose catabolic process"}
{"concept_id": "C3545007", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sperm motility"}
{"concept_id": "C3545008", "aliases": [], "types": ["T044"], "canonical_name": "activation of histone H2A K63-linked ubiquitination"}
{"concept_id": "C3545009", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H2A K63-linked ubiquitination"}
{"concept_id": "C3545021", "aliases": [], "types": ["T044"], "canonical_name": "activation of sterol regulatory element binding protein cleavage"}
{"concept_id": "C3545022", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of sterol regulatory element binding protein cleavage"}
{"concept_id": "C3545023", "aliases": ["up regulation of spermidine biosynthetic process", "activation of spermidine synthesis", "positive regulation of spermidine formation", "activation of spermidine biosynthetic process", "upregulation of spermidine biosynthetic process", "up-regulation of spermidine formation", "up-regulation of spermidine biosynthesis", "up regulation of spermidine anabolism", "up regulation of spermidine biosynthesis", "up-regulation of spermidine biosynthetic process", "activation of spermidine anabolism", "positive regulation of spermidine synthesis", "up regulation of spermidine formation", "upregulation of spermidine anabolism", "activation of spermidine biosynthesis", "positive regulation of spermidine biosynthesis", "positive regulation of spermidine anabolism", "up regulation of spermidine synthesis", "up-regulation of spermidine anabolism", "upregulation of spermidine formation", "up-regulation of spermidine synthesis", "upregulation of spermidine biosynthesis", "activation of spermidine formation", "upregulation of spermidine synthesis"], "types": ["T044"], "canonical_name": "positive regulation of spermidine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of spermidine biosynthetic process. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3545024", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of spermidine biosynthetic process"}
{"concept_id": "C3545025", "aliases": ["negative regulation of COPII coat-cargo complex assembly", "down regulation of COPII coat-cargo complex assembly", "down-regulation of COPII coat-cargo complex assembly"], "types": ["T043"], "canonical_name": "downregulation of COPII coat-cargo complex assembly"}
{"concept_id": "C3545026", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of COPII vesicle protein binding"}
{"concept_id": "C3545027", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of COPII coat-cargo complex assembly"}
{"concept_id": "C3545028", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cargo loading into COPII-coated vesicle"}
{"concept_id": "C3545029", "aliases": [], "types": ["T043"], "canonical_name": "regulation of COPII coat-cargo complex assembly"}
{"concept_id": "C3545030", "aliases": [], "types": ["T043"], "canonical_name": "activation of hydrogen peroxide-mediated programmed cell death"}
{"concept_id": "C3545031", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hydrogen peroxide-mediated programmed cell death"}
{"concept_id": "C3545036", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of double-strand break repair via single-strand annealing"}
{"concept_id": "C3545037", "aliases": [], "types": ["T043"], "canonical_name": "activation of sorocarp spore cell differentiation"}
{"concept_id": "C3545038", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sorocarp spore cell differentiation"}
{"concept_id": "C3545039", "aliases": [], "types": ["T044"], "canonical_name": "EF-P lysine hydroxylation"}
{"concept_id": "C3545040", "aliases": [], "types": ["T044"], "canonical_name": "activation of macrophage colony-stimulating factor production"}
{"concept_id": "C3545041", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of macrophage colony-stimulating factor production"}
{"concept_id": "C3545042", "aliases": [], "types": ["T038"], "canonical_name": "activation of egress of virus within host cell"}
{"concept_id": "C3545043", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of egress of virus within host cell"}
{"concept_id": "C3545044", "aliases": ["activation of pulmonary goblet cell differentiation"], "types": ["T043"], "canonical_name": "activation of lung goblet cell differentiation"}
{"concept_id": "C3545045", "aliases": ["inhibition of pulmonary goblet cell differentiation"], "types": ["T043"], "canonical_name": "inhibition of lung goblet cell differentiation"}
{"concept_id": "C3545046", "aliases": [], "types": ["T043"], "canonical_name": "activation of lung ciliated cell differentiation"}
{"concept_id": "C3545047", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lung ciliated cell differentiation"}
{"concept_id": "C3545048", "aliases": ["positive regulation of toll-like receptor 9 signalling pathway by B cell receptor internalization", "positive regulation of TLR9 signaling pathway by BCR receptor internalization", "positive regulation of toll-like receptor 9 signalling pathway by BCR receptor internalization", "positive regulation of toll-like receptor 9 signaling pathway by BCR receptor internalization", "positive regulation of toll-like receptor 9 signaling pathway by BCR endocytosis", "positive regulation of toll-like receptor 9 signalling pathway by BCR endocytosis", "BCR-induced TLR9 recruitment", "positive regulation of TLR9 signaling pathway by BCR endocytosis", "positive regulation of TLR9 signaling pathway by B cell receptor internalization"], "types": ["T044"], "canonical_name": "positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization", "definition": "The movement of a B cell receptor (BCR) from the plasma membrane to the inside of the cell, which results in positive regulation of toll-like receptor 9 (TLR9) signaling. For example, internalized BCR signals to recruit TLR9 from multiple small endosomes to large autophagosome-like compartments to enhance TLR9 signaling. [GOC:amm, GOC:bf, GOC:TermGenie, PMID:18513998]"}
{"concept_id": "C3545055", "aliases": [], "types": ["T038"], "canonical_name": "activation of convergent extension involved in axis elongation"}
{"concept_id": "C3545056", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of convergent extension involved in axis elongation"}
{"concept_id": "C3545057", "aliases": ["activation of non-canonical Wnt receptor signalling pathway via JNK cascade"], "types": ["T044"], "canonical_name": "activation of non-canonical Wnt receptor signaling pathway via JNK cascade"}
{"concept_id": "C3545058", "aliases": ["inhibition of non-canonical Wnt receptor signalling pathway via JNK cascade"], "types": ["T044"], "canonical_name": "inhibition of non-canonical Wnt receptor signaling pathway via JNK cascade"}
{"concept_id": "C3545110", "aliases": ["up regulation of p52-dependent NF-kappaB signaling", "up-regulation of p52-dependent NF-kappaB signaling"], "types": ["T044"], "canonical_name": "upregulation of p52-dependent NF-kappaB signaling"}
{"concept_id": "C3545111", "aliases": ["up-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway", "up regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway"], "types": ["T044"], "canonical_name": "upregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway"}
{"concept_id": "C3545112", "aliases": ["up-regulation of noncanonical NF-kappaB signaling", "up regulation of noncanonical NF-kappaB signaling"], "types": ["T044"], "canonical_name": "upregulation of noncanonical NF-kappaB signaling"}
{"concept_id": "C3545113", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of non-canonical NF-KB signaling"}
{"concept_id": "C3545114", "aliases": ["up-regulation of non-canonical NF-KB signaling"], "types": ["T044"], "canonical_name": "up regulation of non-canonical NF-KB signaling"}
{"concept_id": "C3545115", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of p52-dependent NF-kappaB signaling"}
{"concept_id": "C3545116", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway"}
{"concept_id": "C3545117", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of noncanonical NF-kappaB signaling"}
{"concept_id": "C3545118", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of non-canonical NF-KB signaling"}
{"concept_id": "C3545119", "aliases": [], "types": ["T044"], "canonical_name": "activation of p52-dependent NF-kappaB signaling"}
{"concept_id": "C3545120", "aliases": [], "types": ["T044"], "canonical_name": "activation of noncanonical nuclear factor kappaB (NF-kappaB) pathway"}
{"concept_id": "C3545121", "aliases": [], "types": ["T044"], "canonical_name": "activation of noncanonical NF-kappaB signaling"}
{"concept_id": "C3545122", "aliases": [], "types": ["T044"], "canonical_name": "activation of non-canonical NF-KB signaling"}
{"concept_id": "C3545123", "aliases": [], "types": ["T044"], "canonical_name": "activation of NIK/NF-kappaB cascade"}
{"concept_id": "C3545124", "aliases": ["down-regulation of p52-dependent NF-kappaB signaling", "down regulation of p52-dependent NF-kappaB signaling", "negative regulation of p52-dependent NF-kappaB signaling"], "types": ["T044"], "canonical_name": "downregulation of p52-dependent NF-kappaB signaling"}
{"concept_id": "C3545125", "aliases": ["negative regulation of non-canonical NF-KB signaling", "negative regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway"], "types": ["T044"], "canonical_name": "negative regulation of noncanonical NF-kappaB signaling"}
{"concept_id": "C3545126", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of p52-dependent NF-kappaB signaling"}
{"concept_id": "C3545127", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of noncanonical nuclear factor kappaB (NF-kappaB) pathway"}
{"concept_id": "C3545128", "aliases": ["inhibition of non-canonical NF-KB signaling"], "types": ["T044"], "canonical_name": "inhibition of noncanonical NF-kappaB signaling"}
{"concept_id": "C3545129", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of NIK/NF-kappaB cascade"}
{"concept_id": "C3545130", "aliases": ["down regulation of non-canonical NF-KB signaling", "downregulation of non-canonical NF-KB signaling", "down-regulation of noncanonical NF-kappaB signaling", "down regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway", "down-regulation of non-canonical NF-KB signaling", "down regulation of noncanonical NF-kappaB signaling", "down-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway", "downregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway"], "types": ["T044"], "canonical_name": "downregulation of noncanonical NF-kappaB signaling"}
{"concept_id": "C3545131", "aliases": [], "types": ["T044"], "canonical_name": "regulation of p52-dependent NF-kappaB signaling"}
{"concept_id": "C3545132", "aliases": [], "types": ["T044"], "canonical_name": "regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway"}
{"concept_id": "C3545133", "aliases": ["regulation of non-canonical NF-KB signaling"], "types": ["T044"], "canonical_name": "regulation of noncanonical NF-kappaB signaling"}
{"concept_id": "C3545134", "aliases": [], "types": ["T039"], "canonical_name": "activation of heart chamber morphogenesis"}
{"concept_id": "C3545135", "aliases": [], "types": ["T039"], "canonical_name": "activation of cardiac chamber morphogenesis"}
{"concept_id": "C3545136", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of heart chamber morphogenesis"}
{"concept_id": "C3545137", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cardiac chamber morphogenesis"}
{"concept_id": "C3545138", "aliases": [], "types": ["T038"], "canonical_name": "phage antiholin"}
{"concept_id": "C3545139", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of holin activity"}
{"concept_id": "C3545140", "aliases": ["activation of neuron death", "activation of neuron cell death"], "types": ["T043"], "canonical_name": "activation of neuronal cell death"}
{"concept_id": "C3545141", "aliases": ["inhibition of neuron death", "inhibition of neuron cell death"], "types": ["T043"], "canonical_name": "inhibition of neuronal cell death"}
{"concept_id": "C3545155", "aliases": [], "types": ["T039"], "canonical_name": "activation of cardiac chamber formation"}
{"concept_id": "C3545156", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cardiac chamber formation"}
{"concept_id": "C3545157", "aliases": [], "types": ["T039"], "canonical_name": "activation of heart looping"}
{"concept_id": "C3545158", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of heart looping"}
{"concept_id": "C3545167", "aliases": [], "types": ["T043"], "canonical_name": "activation of extracellular matrix assembly"}
{"concept_id": "C3545168", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of extracellular matrix assembly"}
{"concept_id": "C3545169", "aliases": ["stimulation of calcium-mediated signaling involved in cellular response to calcium ion"], "types": ["T044"], "canonical_name": "stimulation of calcium-mediated signaling involved in cellular response to Ca2+ ion"}
{"concept_id": "C3545170", "aliases": ["activation of calcium-mediated signaling involved in cellular response to calcium ion"], "types": ["T044"], "canonical_name": "activation of calcium-mediated signaling involved in cellular response to Ca2+ ion"}
{"concept_id": "C3545171", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of calcium-mediated signaling involved in cellular salinity response"}
{"concept_id": "C3545172", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of calcium-mediated signaling involved in cellular response to salt stress"}
{"concept_id": "C3545173", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress"}
{"concept_id": "C3545174", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium-mediated signaling involved in cellular salinity response"}
{"concept_id": "C3545175", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium-mediated signaling involved in cellular response to salt stress"}
{"concept_id": "C3545176", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium-mediated signaling involved in cellular response to ionic osmotic stress"}
{"concept_id": "C3545177", "aliases": [], "types": ["T045"], "canonical_name": "activation of formation of translation preinitiation complex"}
{"concept_id": "C3545178", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of formation of translation preinitiation complex"}
{"concept_id": "C3545179", "aliases": [], "types": ["T045"], "canonical_name": "activation of formation of translation initiation ternary complex"}
{"concept_id": "C3545180", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of formation of translation initiation ternary complex"}
{"concept_id": "C3545181", "aliases": [], "types": ["T044"], "canonical_name": "activation of ephrin receptor signaling pathway"}
{"concept_id": "C3545182", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ephrin receptor signaling pathway"}
{"concept_id": "C3545183", "aliases": ["up regulation of EGFR family signaling pathway", "up-regulation of EGFR family signaling pathway"], "types": ["T044"], "canonical_name": "upregulation of EGFR family signaling pathway"}
{"concept_id": "C3545184", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of EGFR family signaling pathway"}
{"concept_id": "C3545186", "aliases": [], "types": ["T044"], "canonical_name": "activation of EGFR family signaling pathway"}
{"concept_id": "C3545187", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of EGFR family signaling pathway"}
{"concept_id": "C3545189", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of EGFR family signaling pathway"}
{"concept_id": "C3545190", "aliases": ["down regulation of EGFR family signaling pathway", "down-regulation of EGFR family signaling pathway"], "types": ["T044"], "canonical_name": "downregulation of EGFR family signaling pathway"}
{"concept_id": "C3545191", "aliases": [], "types": ["T044"], "canonical_name": "regulation of EGFR family signaling pathway"}
{"concept_id": "C3545192", "aliases": [], "types": ["T044"], "canonical_name": "activation of camalexin biosynthetic process"}
{"concept_id": "C3545193", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to caffeine"}
{"concept_id": "C3545194", "aliases": [], "types": ["T043"], "canonical_name": "activation of trophoblast cell migration"}
{"concept_id": "C3545195", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of trophoblast cell migration"}
{"concept_id": "C3545196", "aliases": [], "types": ["T044"], "canonical_name": "salicylic acid receptor"}
{"concept_id": "C3545197", "aliases": ["expression of extracellular matrix proteins", "extracellular matrix protein production"], "types": ["T045"], "canonical_name": "gene expression involved in extracellular matrix organization", "definition": "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. [GOC:pg, GOC:TermGenie, PMID:18668558]"}
{"concept_id": "C3545201", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of non-classical signal transduction"}
{"concept_id": "C3545202", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of signal transduction in absence of ligand"}
{"concept_id": "C3545203", "aliases": ["down-regulation of non-classical signal transduction", "down regulation of non-classical signal transduction"], "types": ["T044"], "canonical_name": "downregulation of non-classical signal transduction"}
{"concept_id": "C3545204", "aliases": ["down regulation of basal signaling", "down-regulation of basal signaling"], "types": ["T044"], "canonical_name": "downregulation of basal signaling"}
{"concept_id": "C3545205", "aliases": [], "types": ["T043"], "canonical_name": "activation of autophagic vacuole maturation"}
{"concept_id": "C3545206", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of autophagic vacuole maturation"}
{"concept_id": "C3545207", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein homotetramerization"}
{"concept_id": "C3545208", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein homotetramer formation"}
{"concept_id": "C3545209", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein homotetramer biosynthetic process"}
{"concept_id": "C3545210", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein homotetramer biosynthesis"}
{"concept_id": "C3545211", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein homotetramer assembly"}
{"concept_id": "C3545212", "aliases": ["inhibition of protein homotetramer formation", "inhibition of protein homotetramerization", "inhibition of protein homotetramer biosynthetic process", "inhibition of protein homotetramer biosynthesis"], "types": ["T043"], "canonical_name": "inhibition of protein homotetramer assembly"}
{"concept_id": "C3545213", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein tetramerization"}
{"concept_id": "C3545214", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein tetramer formation"}
{"concept_id": "C3545215", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein tetramer biosynthetic process"}
{"concept_id": "C3545216", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein tetramer biosynthesis"}
{"concept_id": "C3545217", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein tetramer assembly"}
{"concept_id": "C3545218", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein tetramerization"}
{"concept_id": "C3545219", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein tetramer formation"}
{"concept_id": "C3545220", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein tetramer biosynthetic process"}
{"concept_id": "C3545221", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein tetramer biosynthesis"}
{"concept_id": "C3545222", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein tetramer assembly"}
{"concept_id": "C3545225", "aliases": [], "types": ["T039"], "canonical_name": "activation of relaxation of muscle"}
{"concept_id": "C3545226", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of relaxation of muscle"}
{"concept_id": "C3545227", "aliases": [], "types": ["T040"], "canonical_name": "activation of engulfment of cell corpse"}
{"concept_id": "C3545228", "aliases": [], "types": ["T040"], "canonical_name": "activation of engulfment of apoptotic cell corpse"}
{"concept_id": "C3545229", "aliases": [], "types": ["T040"], "canonical_name": "activation of engulfment of apoptotic cell"}
{"concept_id": "C3545230", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of engulfment of cell corpse"}
{"concept_id": "C3545231", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of engulfment of apoptotic cell corpse"}
{"concept_id": "C3545232", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of engulfment of apoptotic cell"}
{"concept_id": "C3545234", "aliases": ["positive regulation of egg laying", "upregulation of oviposition", "upregulation of egg laying", "positive regulation of egg-laying", "up-regulation of egg laying", "upregulation of egg-laying", "up regulation of egg-laying", "up regulation of egg laying", "up-regulation of oviposition", "up-regulation of egg-laying", "up regulation of oviposition"], "types": ["T038"], "canonical_name": "positive regulation of oviposition", "definition": "Any process that activates or increases the frequency, rate or extent of oviposition. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3545235", "aliases": ["activation of oviposition", "activation of egg-laying"], "types": ["T038"], "canonical_name": "activation of egg laying"}
{"concept_id": "C3545236", "aliases": ["down regulation of oviposition", "negative regulation of egg laying", "down-regulation of oviposition", "downregulation of oviposition", "negative regulation of egg-laying"], "types": ["T038"], "canonical_name": "negative regulation of oviposition", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oviposition. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3545237", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of oviposition"}
{"concept_id": "C3545238", "aliases": ["inhibition of egg-laying"], "types": ["T038"], "canonical_name": "inhibition of egg laying"}
{"concept_id": "C3545239", "aliases": ["down regulation of egg-laying", "down-regulation of egg laying", "down-regulation of egg-laying"], "types": ["T038"], "canonical_name": "down regulation of egg laying"}
{"concept_id": "C3545241", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptide antigen transport"}
{"concept_id": "C3545242", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptide antigen transport"}
{"concept_id": "C3545243", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-glutamine import"}
{"concept_id": "C3545244", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-glutamine import"}
{"concept_id": "C3545245", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to reactive oxygen species"}
{"concept_id": "C3545246", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to reactive oxygen species"}
{"concept_id": "C3545247", "aliases": ["activation of MOMP"], "types": ["T043"], "canonical_name": "activation of mitochondrial outer membrane permeabilization"}
{"concept_id": "C3545248", "aliases": ["inhibition of MOMP"], "types": ["T043"], "canonical_name": "inhibition of mitochondrial outer membrane permeabilization"}
{"concept_id": "C3545249", "aliases": [], "types": ["T038"], "canonical_name": "activation of calcium ion transmembrane transporter activity"}
{"concept_id": "C3545250", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcium ion transmembrane transporter activity"}
{"concept_id": "C3545251", "aliases": [], "types": ["T038"], "canonical_name": "activation of potassium ion transmembrane transporter activity"}
{"concept_id": "C3545252", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of potassium ion transmembrane transporter activity"}
{"concept_id": "C3545253", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of fermentation"}
{"concept_id": "C3545254", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to salt stress"}
{"concept_id": "C3545255", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to salt stress"}
{"concept_id": "C3545256", "aliases": ["upregulation of dibenzopyrazine biosynthetic process"], "types": ["T044"], "canonical_name": "upregulation of dibenzopyrazine biosynthesis"}
{"concept_id": "C3545257", "aliases": ["upregulation of dibenzo-p-diazine biosynthetic process"], "types": ["T044"], "canonical_name": "upregulation of dibenzo-p-diazine biosynthesis"}
{"concept_id": "C3545258", "aliases": ["upregulation of azophenylene biosynthetic process"], "types": ["T044"], "canonical_name": "upregulation of azophenylene biosynthesis"}
{"concept_id": "C3545259", "aliases": ["upregulation of acridizine biosynthetic process"], "types": ["T044"], "canonical_name": "upregulation of acridizine biosynthesis"}
{"concept_id": "C3545260", "aliases": ["up-regulation of dibenzopyrazine biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of dibenzopyrazine biosynthetic process"}
{"concept_id": "C3545261", "aliases": ["up-regulation of dibenzopyrazine biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of dibenzopyrazine biosynthesis"}
{"concept_id": "C3545262", "aliases": ["up-regulation of dibenzo-p-diazine biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of dibenzo-p-diazine biosynthetic process"}
{"concept_id": "C3545263", "aliases": ["up-regulation of dibenzo-p-diazine biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of dibenzo-p-diazine biosynthesis"}
{"concept_id": "C3545264", "aliases": ["up-regulation of azophenylene biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of azophenylene biosynthetic process"}
{"concept_id": "C3545265", "aliases": ["up-regulation of azophenylene biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of azophenylene biosynthesis"}
{"concept_id": "C3545266", "aliases": ["up-regulation of acridizine biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of acridizine biosynthetic process"}
{"concept_id": "C3545267", "aliases": ["up-regulation of acridizine biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of acridizine biosynthesis"}
{"concept_id": "C3545268", "aliases": ["positive regulation of dibenzopyrazine biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of dibenzopyrazine biosynthesis"}
{"concept_id": "C3545269", "aliases": ["positive regulation of dibenzo-p-diazine biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of dibenzo-p-diazine biosynthesis"}
{"concept_id": "C3545270", "aliases": ["positive regulation of azophenylene biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of azophenylene biosynthesis"}
{"concept_id": "C3545271", "aliases": ["positive regulation of acridizine biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of acridizine biosynthesis"}
{"concept_id": "C3545272", "aliases": [], "types": ["T044"], "canonical_name": "activation of phenazine biosynthetic process"}
{"concept_id": "C3545273", "aliases": ["activation of dibenzopyrazine biosynthetic process"], "types": ["T044"], "canonical_name": "activation of dibenzopyrazine biosynthesis"}
{"concept_id": "C3545274", "aliases": ["activation of dibenzo-p-diazine biosynthetic process"], "types": ["T044"], "canonical_name": "activation of dibenzo-p-diazine biosynthesis"}
{"concept_id": "C3545275", "aliases": ["activation of azophenylene biosynthetic process"], "types": ["T044"], "canonical_name": "activation of azophenylene biosynthesis"}
{"concept_id": "C3545276", "aliases": ["activation of acridizine biosynthetic process"], "types": ["T044"], "canonical_name": "activation of acridizine biosynthesis"}
{"concept_id": "C3545277", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of dibenzopyrazine biosynthetic process"}
{"concept_id": "C3545278", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of dibenzopyrazine biosynthesis"}
{"concept_id": "C3545279", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of dibenzo-p-diazine biosynthetic process"}
{"concept_id": "C3545280", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of dibenzo-p-diazine biosynthesis"}
{"concept_id": "C3545281", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of azophenylene biosynthetic process"}
{"concept_id": "C3545282", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of azophenylene biosynthesis"}
{"concept_id": "C3545283", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of acridizine biosynthetic process"}
{"concept_id": "C3545284", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of acridizine biosynthesis"}
{"concept_id": "C3545285", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phenazine biosynthetic process"}
{"concept_id": "C3545286", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of dibenzopyrazine biosynthetic process"}
{"concept_id": "C3545287", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of dibenzopyrazine biosynthesis"}
{"concept_id": "C3545288", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of dibenzo-p-diazine biosynthetic process"}
{"concept_id": "C3545289", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of dibenzo-p-diazine biosynthesis"}
{"concept_id": "C3545290", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of azophenylene biosynthetic process"}
{"concept_id": "C3545291", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of azophenylene biosynthesis"}
{"concept_id": "C3545292", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acridizine biosynthetic process"}
{"concept_id": "C3545293", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acridizine biosynthesis"}
{"concept_id": "C3545294", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of dibenzopyrazine biosynthetic process"}
{"concept_id": "C3545295", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of dibenzopyrazine biosynthesis"}
{"concept_id": "C3545296", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of dibenzo-p-diazine biosynthetic process"}
{"concept_id": "C3545297", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of dibenzo-p-diazine biosynthesis"}
{"concept_id": "C3545298", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of azophenylene biosynthetic process"}
{"concept_id": "C3545299", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of azophenylene biosynthesis"}
{"concept_id": "C3545300", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of acridizine biosynthetic process"}
{"concept_id": "C3545301", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of acridizine biosynthesis"}
{"concept_id": "C3545302", "aliases": ["down-regulation of dibenzopyrazine biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of dibenzopyrazine biosynthetic process"}
{"concept_id": "C3545303", "aliases": ["down-regulation of dibenzopyrazine biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of dibenzopyrazine biosynthesis"}
{"concept_id": "C3545304", "aliases": ["down-regulation of dibenzo-p-diazine biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of dibenzo-p-diazine biosynthesis"}
{"concept_id": "C3545305", "aliases": ["down-regulation of azophenylene biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of azophenylene biosynthetic process"}
{"concept_id": "C3545306", "aliases": ["down-regulation of azophenylene biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of azophenylene biosynthesis"}
{"concept_id": "C3545307", "aliases": ["down-regulation of acridizine biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of acridizine biosynthetic process"}
{"concept_id": "C3545308", "aliases": ["down-regulation of acridizine biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of acridizine biosynthesis"}
{"concept_id": "C3545309", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dibenzopyrazine biosynthetic process"}
{"concept_id": "C3545310", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dibenzopyrazine biosynthesis"}
{"concept_id": "C3545311", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dibenzo-p-diazine biosynthetic process"}
{"concept_id": "C3545312", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dibenzo-p-diazine biosynthesis"}
{"concept_id": "C3545313", "aliases": [], "types": ["T044"], "canonical_name": "regulation of azophenylene biosynthetic process"}
{"concept_id": "C3545314", "aliases": [], "types": ["T044"], "canonical_name": "regulation of azophenylene biosynthesis"}
{"concept_id": "C3545315", "aliases": [], "types": ["T044"], "canonical_name": "regulation of acridizine biosynthetic process"}
{"concept_id": "C3545316", "aliases": [], "types": ["T044"], "canonical_name": "regulation of acridizine biosynthesis"}
{"concept_id": "C3545317", "aliases": [], "types": ["T044"], "canonical_name": "activation of tatiopterin metabolic process"}
{"concept_id": "C3545318", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tatiopterin metabolic process"}
{"concept_id": "C3545319", "aliases": ["activation of tatiopterin anabolism", "up regulation of tatiopterin biosynthesis", "up-regulation of tatiopterin formation", "up-regulation of tatiopterin anabolism", "activation of tatiopterin formation", "upregulation of tatiopterin biosynthesis", "positive regulation of tatiopterin formation", "up regulation of tatiopterin anabolism", "up-regulation of tatiopterin synthesis", "activation of tatiopterin biosynthesis", "up regulation of tatiopterin formation", "positive regulation of tatiopterin anabolism", "activation of tatiopterin synthesis", "up-regulation of tatiopterin biosynthesis", "upregulation of tatiopterin anabolism", "upregulation of tatiopterin biosynthetic process", "up regulation of tatiopterin biosynthetic process", "positive regulation of tatiopterin synthesis", "activation of tatiopterin biosynthetic process", "up-regulation of tatiopterin biosynthetic process", "upregulation of tatiopterin synthesis", "up regulation of tatiopterin synthesis", "positive regulation of tatiopterin biosynthesis", "upregulation of tatiopterin formation"], "types": ["T044"], "canonical_name": "positive regulation of tatiopterin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of tatiopterin biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545320", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tatiopterin biosynthetic process"}
{"concept_id": "C3545321", "aliases": ["upregulation of sarcinapterin anabolism", "positive regulation of sarcinapterin biosynthesis", "upregulation of sarcinapterin synthesis", "up-regulation of sarcinapterin biosynthesis", "up regulation of sarcinapterin anabolism", "up-regulation of sarcinapterin formation", "activation of sarcinapterin biosynthesis", "activation of sarcinapterin synthesis", "up regulation of sarcinapterin formation", "up-regulation of sarcinapterin anabolism", "positive regulation of sarcinapterin formation", "activation of sarcinapterin anabolism", "activation of sarcinapterin biosynthetic process", "up regulation of sarcinapterin biosynthesis", "positive regulation of sarcinapterin synthesis", "up-regulation of sarcinapterin synthesis", "positive regulation of sarcinapterin anabolism", "upregulation of sarcinapterin biosynthesis", "upregulation of sarcinapterin biosynthetic process", "upregulation of sarcinapterin formation", "up-regulation of sarcinapterin biosynthetic process", "up regulation of sarcinapterin synthesis", "up regulation of sarcinapterin biosynthetic process", "activation of sarcinapterin formation"], "types": ["T044"], "canonical_name": "positive regulation of sarcinapterin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of sarcinapterin biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545322", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sarcinapterin biosynthetic process"}
{"concept_id": "C3545323", "aliases": [], "types": ["T044"], "canonical_name": "activation of sarcinapterin metabolic process"}
{"concept_id": "C3545324", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sarcinapterin metabolic process"}
{"concept_id": "C3545325", "aliases": [], "types": ["T044"], "canonical_name": "activation of methanophenazine metabolic process"}
{"concept_id": "C3545326", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methanophenazine metabolic process"}
{"concept_id": "C3545327", "aliases": ["upregulation of methanophenazine formation", "positive regulation of methanophenazine biosynthesis", "upregulation of methanophenazine anabolism", "upregulation of methanophenazine biosynthesis", "up regulation of methanophenazine anabolism", "positive regulation of methanophenazine synthesis", "activation of methanophenazine formation", "positive regulation of methanophenazine anabolism", "up-regulation of methanophenazine biosynthesis", "activation of methanophenazine biosynthesis", "up-regulation of methanophenazine formation", "upregulation of methanophenazine biosynthetic process", "positive regulation of methanophenazine formation", "up regulation of methanophenazine biosynthetic process", "activation of methanophenazine synthesis", "activation of methanophenazine biosynthetic process", "up regulation of methanophenazine synthesis", "activation of methanophenazine anabolism", "upregulation of methanophenazine synthesis", "up regulation of methanophenazine biosynthesis", "up regulation of methanophenazine formation", "up-regulation of methanophenazine synthesis", "up-regulation of methanophenazine biosynthetic process", "up-regulation of methanophenazine anabolism"], "types": ["T044"], "canonical_name": "positive regulation of methanophenazine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of methanophenazine biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545328", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methanophenazine biosynthetic process"}
{"concept_id": "C3545329", "aliases": [], "types": ["T044"], "canonical_name": "activation of 17-methylnonadec-1-ene metabolic process"}
{"concept_id": "C3545330", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 17-methylnonadec-1-ene metabolic process"}
{"concept_id": "C3545331", "aliases": ["upregulation of 17-methylnonadec-1-ene formation", "up regulation of 17-methylnonadec-1-ene synthesis", "up-regulation of 17-methylnonadec-1-ene biosynthetic process", "upregulation of 17-methylnonadec-1-ene anabolism", "activation of 17-methylnonadec-1-ene synthesis", "positive regulation of 17-methylnonadec-1-ene formation", "activation of 17-methylnonadec-1-ene biosynthesis", "up regulation of 17-methylnonadec-1-ene biosynthetic process", "activation of 17-methylnonadec-1-ene anabolism", "up-regulation of 17-methylnonadec-1-ene anabolism", "upregulation of 17-methylnonadec-1-ene synthesis", "up regulation of 17-methylnonadec-1-ene biosynthesis", "up-regulation of 17-methylnonadec-1-ene biosynthesis", "positive regulation of 17-methylnonadec-1-ene anabolism", "up-regulation of 17-methylnonadec-1-ene synthesis", "activation of 17-methylnonadec-1-ene biosynthetic process", "up-regulation of 17-methylnonadec-1-ene formation", "up regulation of 17-methylnonadec-1-ene anabolism", "up regulation of 17-methylnonadec-1-ene formation", "positive regulation of 17-methylnonadec-1-ene synthesis", "activation of 17-methylnonadec-1-ene formation", "upregulation of 17-methylnonadec-1-ene biosynthetic process", "positive regulation of 17-methylnonadec-1-ene biosynthesis", "upregulation of 17-methylnonadec-1-ene biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of 17-methylnonadec-1-ene biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545332", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 17-methylnonadec-1-ene biosynthetic process"}
{"concept_id": "C3545333", "aliases": [], "types": ["T044"], "canonical_name": "activation of 18-methylnonadec-1-ene metabolic process"}
{"concept_id": "C3545334", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 18-methylnonadec-1-ene metabolic process"}
{"concept_id": "C3545335", "aliases": ["up regulation of 18-methylnonadec-1-ene formation", "positive regulation of 18-methylnonadec-1-ene synthesis", "upregulation of 18-methylnonadec-1-ene synthesis", "up regulation of 18-methylnonadec-1-ene biosynthesis", "up regulation of 18-methylnonadec-1-ene anabolism", "upregulation of 18-methylnonadec-1-ene anabolism", "upregulation of 18-methylnonadec-1-ene biosynthetic process", "up-regulation of 18-methylnonadec-1-ene synthesis", "activation of 18-methylnonadec-1-ene biosynthesis", "upregulation of 18-methylnonadec-1-ene biosynthesis", "up-regulation of 18-methylnonadec-1-ene biosynthetic process", "positive regulation of 18-methylnonadec-1-ene anabolism", "positive regulation of 18-methylnonadec-1-ene formation", "up-regulation of 18-methylnonadec-1-ene biosynthesis", "up-regulation of 18-methylnonadec-1-ene formation", "upregulation of 18-methylnonadec-1-ene formation", "up regulation of 18-methylnonadec-1-ene synthesis", "activation of 18-methylnonadec-1-ene biosynthetic process", "up regulation of 18-methylnonadec-1-ene biosynthetic process", "up-regulation of 18-methylnonadec-1-ene anabolism", "activation of 18-methylnonadec-1-ene anabolism", "activation of 18-methylnonadec-1-ene synthesis", "activation of 18-methylnonadec-1-ene formation", "positive regulation of 18-methylnonadec-1-ene biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of 18-methylnonadec-1-ene biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545336", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 18-methylnonadec-1-ene biosynthetic process"}
{"concept_id": "C3545337", "aliases": ["up-regulation of hemiterpene biosynthetic process", "up regulation of hemiterpene biosynthesis", "up regulation of hemiterpene biosynthetic process", "upregulation of 2-methyl-1,3-butadiene biosynthesis", "upregulation of isoprene biosynthetic process", "positive regulation of 2-methyl-1,3-butadiene biosynthetic process", "activation of hemiterpene biosynthetic process", "activation of hemiterpene biosynthesis", "up-regulation of 2-methyl-1,3-butadiene biosynthetic process", "up regulation of 2-methyl-1,3-butadiene biosynthesis", "up-regulation of isoprene biosynthetic process", "positive regulation of hemiterpene biosynthetic process", "positive regulation of hemiterpene biosynthesis", "up-regulation of 2-methyl-1,3-butadiene biosynthesis", "activation of isoprene biosynthetic process", "positive regulation of 2-methyl-1,3-butadiene biosynthesis", "up regulation of 2-methyl-1,3-butadiene biosynthetic process", "upregulation of 2-methyl-1,3-butadiene biosynthetic process", "up-regulation of hemiterpene biosynthesis", "up regulation of isoprene biosynthetic process", "activation of 2-methyl-1,3-butadiene biosynthetic process", "activation of 2-methyl-1,3-butadiene biosynthesis", "upregulation of hemiterpene biosynthesis", "upregulation of hemiterpene biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of isoprene biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of isoprene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545338", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoprene biosynthetic process"}
{"concept_id": "C3545339", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hemiterpene biosynthetic process"}
{"concept_id": "C3545340", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hemiterpene biosynthesis"}
{"concept_id": "C3545341", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 2-methyl-1,3-butadiene biosynthetic process"}
{"concept_id": "C3545342", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 2-methyl-1,3-butadiene biosynthesis"}
{"concept_id": "C3545343", "aliases": [], "types": ["T044"], "canonical_name": "activation of isoprene metabolism"}
{"concept_id": "C3545344", "aliases": [], "types": ["T044"], "canonical_name": "activation of isoprene metabolic process"}
{"concept_id": "C3545345", "aliases": [], "types": ["T044"], "canonical_name": "activation of hemiterpene metabolism"}
{"concept_id": "C3545346", "aliases": [], "types": ["T044"], "canonical_name": "activation of hemiterpene metabolic process"}
{"concept_id": "C3545347", "aliases": [], "types": ["T044"], "canonical_name": "activation of 2-methyl-1,3-butadiene metabolism"}
{"concept_id": "C3545348", "aliases": [], "types": ["T044"], "canonical_name": "activation of 2-methyl-1,3-butadiene metabolic process"}
{"concept_id": "C3545349", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoprene metabolism"}
{"concept_id": "C3545350", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoprene metabolic process"}
{"concept_id": "C3545351", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hemiterpene metabolism"}
{"concept_id": "C3545352", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hemiterpene metabolic process"}
{"concept_id": "C3545353", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 2-methyl-1,3-butadiene metabolism"}
{"concept_id": "C3545354", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 2-methyl-1,3-butadiene metabolic process"}
{"concept_id": "C3545355", "aliases": [], "types": ["T044"], "canonical_name": "activation of (Z)-nonadeca-1,14-diene synthesis"}
{"concept_id": "C3545356", "aliases": [], "types": ["T044"], "canonical_name": "activation of (Z)-nonadeca-1,14-diene formation"}
{"concept_id": "C3545357", "aliases": [], "types": ["T044"], "canonical_name": "activation of (Z)-nonadeca-1,14-diene biosynthetic process"}
{"concept_id": "C3545358", "aliases": [], "types": ["T044"], "canonical_name": "activation of (Z)-nonadeca-1,14-diene biosynthesis"}
{"concept_id": "C3545359", "aliases": [], "types": ["T044"], "canonical_name": "activation of (Z)-nonadeca-1,14-diene anabolism"}
{"concept_id": "C3545360", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of (Z)-nonadeca-1,14-diene synthesis"}
{"concept_id": "C3545361", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of (Z)-nonadeca-1,14-diene formation"}
{"concept_id": "C3545362", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of (Z)-nonadeca-1,14-diene biosynthetic process"}
{"concept_id": "C3545363", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of (Z)-nonadeca-1,14-diene biosynthesis"}
{"concept_id": "C3545364", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of (Z)-nonadeca-1,14-diene anabolism"}
{"concept_id": "C3545365", "aliases": [], "types": ["T044"], "canonical_name": "activation of (Z)-nonadeca-1,14-diene metabolic process"}
{"concept_id": "C3545366", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of (Z)-nonadeca-1,14-diene metabolic process"}
{"concept_id": "C3545367", "aliases": ["up-regulation of nonadec-1-ene synthesis", "up regulation of nonadec-1-ene synthesis", "up regulation of nonadec-1-ene biosynthetic process", "positive regulation of nonadec-1-ene biosynthesis", "up regulation of nonadec-1-ene anabolism", "activation of nonadec-1-ene anabolism", "up-regulation of nonadec-1-ene formation", "positive regulation of nonadec-1-ene formation", "up regulation of nonadec-1-ene biosynthesis", "upregulation of nonadec-1-ene anabolism", "upregulation of nonadec-1-ene synthesis", "up-regulation of nonadec-1-ene biosynthetic process", "up-regulation of nonadec-1-ene biosynthesis", "activation of nonadec-1-ene formation", "up regulation of nonadec-1-ene formation", "activation of nonadec-1-ene biosynthesis", "up-regulation of nonadec-1-ene anabolism", "upregulation of nonadec-1-ene formation", "activation of nonadec-1-ene synthesis", "upregulation of nonadec-1-ene biosynthesis", "positive regulation of nonadec-1-ene synthesis", "upregulation of nonadec-1-ene biosynthetic process", "activation of nonadec-1-ene biosynthetic process", "positive regulation of nonadec-1-ene anabolism"], "types": ["T044"], "canonical_name": "positive regulation of nonadec-1-ene biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545368", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nonadec-1-ene biosynthetic process"}
{"concept_id": "C3545369", "aliases": [], "types": ["T044"], "canonical_name": "activation of nonadec-1-ene metabolic process"}
{"concept_id": "C3545370", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nonadec-1-ene metabolic process"}
{"concept_id": "C3545371", "aliases": ["upregulation of L-tyrosine uptake", "up regulation of L-tyrosine uptake", "up-regulation of L-tyrosine uptake"], "types": ["T044"], "canonical_name": "positive regulation of L-tyrosine uptake"}
{"concept_id": "C3545372", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-tyrosine uptake"}
{"concept_id": "C3545373", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-tyrosine import"}
{"concept_id": "C3545374", "aliases": ["negative regulation of L-tyrosine import", "down-regulation of L-tyrosine import", "negative regulation of L-tyrosine uptake", "downregulation of L-tyrosine import", "down regulation of L-tyrosine import"], "types": ["T044"], "canonical_name": "negative regulation of L-tyrosine import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-tyrosine import into the cell. [GOC:TermGenie]"}
{"concept_id": "C3545375", "aliases": ["inhibition of L-tyrosine uptake"], "types": ["T044"], "canonical_name": "inhibition of L-tyrosine import"}
{"concept_id": "C3545376", "aliases": ["down regulation of L-tyrosine uptake", "down-regulation of L-tyrosine uptake"], "types": ["T044"], "canonical_name": "downregulation of L-tyrosine uptake"}
{"concept_id": "C3545377", "aliases": ["up regulation of L-threonine uptake", "up-regulation of L-threonine uptake"], "types": ["T044"], "canonical_name": "upregulation of L-threonine uptake"}
{"concept_id": "C3545378", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of L-threonine uptake"}
{"concept_id": "C3545379", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-threonine uptake"}
{"concept_id": "C3545380", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-threonine import"}
{"concept_id": "C3545381", "aliases": ["downregulation of L-threonine import", "negative regulation of L-threonine uptake", "down regulation of L-threonine import", "down-regulation of L-threonine import"], "types": ["T044"], "canonical_name": "negative regulation of L-threonine import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-threonine import into cell. [GOC:TermGenie]"}
{"concept_id": "C3545382", "aliases": ["inhibition of L-threonine uptake"], "types": ["T044"], "canonical_name": "inhibition of L-threonine import"}
{"concept_id": "C3545383", "aliases": ["down-regulation of L-threonine uptake", "down regulation of L-threonine uptake"], "types": ["T044"], "canonical_name": "downregulation of L-threonine uptake"}
{"concept_id": "C3545384", "aliases": [], "types": ["T044"], "canonical_name": "activation of glycine import"}
{"concept_id": "C3545385", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glycine import"}
{"concept_id": "C3545393", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of octadecene metabolism"}
{"concept_id": "C3545394", "aliases": ["up-regulation of octadecene metabolism"], "types": ["T044"], "canonical_name": "up regulation of octadecene metabolism"}
{"concept_id": "C3545395", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of octadecene metabolism"}
{"concept_id": "C3545396", "aliases": [], "types": ["T044"], "canonical_name": "activation of octadecene metabolism"}
{"concept_id": "C3545397", "aliases": [], "types": ["T044"], "canonical_name": "activation of octadecene metabolic process"}
{"concept_id": "C3545398", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of octadecene metabolism"}
{"concept_id": "C3545399", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of octadecene metabolism"}
{"concept_id": "C3545400", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of octadecene metabolic process"}
{"concept_id": "C3545401", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of octadecene metabolism"}
{"concept_id": "C3545402", "aliases": ["down-regulation of octadecene metabolism"], "types": ["T044"], "canonical_name": "down regulation of octadecene metabolism"}
{"concept_id": "C3545403", "aliases": ["upregulation of octadecene formation", "upregulation of octadecene synthesis", "upregulation of octadecene biosynthesis"], "types": ["T044"], "canonical_name": "upregulation of octadecene anabolism"}
{"concept_id": "C3545404", "aliases": ["up regulation of 1-octadecene biosynthetic process", "up-regulation of 1-octadecene biosynthetic process", "upregulation of 1-octadecene biosynthetic process", "positive regulation of 1-octadecene biosynthetic process"], "types": ["T044"], "canonical_name": "activation of 1-octadecene biosynthetic process"}
{"concept_id": "C3545405", "aliases": ["up-regulation of octadecene synthesis"], "types": ["T044"], "canonical_name": "up regulation of octadecene synthesis"}
{"concept_id": "C3545406", "aliases": ["up-regulation of octadecene formation"], "types": ["T044"], "canonical_name": "up regulation of octadecene formation"}
{"concept_id": "C3545407", "aliases": ["up-regulation of octadecene biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of octadecene biosynthesis"}
{"concept_id": "C3545408", "aliases": ["up regulation of octadecene anabolism", "up-regulation of octadecene anabolism"], "types": ["T044"], "canonical_name": "positive regulation of octadecene anabolism"}
{"concept_id": "C3545409", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of octadecene synthesis"}
{"concept_id": "C3545410", "aliases": ["positive regulation of octadecene formation"], "types": ["T044"], "canonical_name": "positive regulation of octadecene biosynthesis"}
{"concept_id": "C3545411", "aliases": ["activation of octadecene formation", "activation of octadecene synthesis", "activation of octadecene biosynthetic process", "activation of octadecene biosynthesis"], "types": ["T044"], "canonical_name": "activation of octadecene anabolism"}
{"concept_id": "C3545412", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of octadecene synthesis"}
{"concept_id": "C3545413", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of octadecene formation"}
{"concept_id": "C3545414", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of octadecene biosynthesis"}
{"concept_id": "C3545415", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of octadecene anabolism"}
{"concept_id": "C3545416", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 1-octadecene biosynthetic process"}
{"concept_id": "C3545417", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of octadecene synthesis"}
{"concept_id": "C3545418", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of octadecene formation"}
{"concept_id": "C3545419", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of octadecene biosynthetic process"}
{"concept_id": "C3545420", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of octadecene biosynthesis"}
{"concept_id": "C3545421", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of octadecene anabolism"}
{"concept_id": "C3545422", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1-octadecene biosynthetic process"}
{"concept_id": "C3545423", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of octadecene synthesis"}
{"concept_id": "C3545424", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of octadecene formation"}
{"concept_id": "C3545425", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of octadecene biosynthesis"}
{"concept_id": "C3545426", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of 1-octadecene biosynthetic process"}
{"concept_id": "C3545427", "aliases": ["down-regulation of octadecene synthesis"], "types": ["T044"], "canonical_name": "down regulation of octadecene synthesis"}
{"concept_id": "C3545428", "aliases": ["down-regulation of octadecene formation"], "types": ["T044"], "canonical_name": "down regulation of octadecene formation"}
{"concept_id": "C3545429", "aliases": ["down-regulation of octadecene biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of octadecene biosynthesis"}
{"concept_id": "C3545430", "aliases": ["down-regulation of octadecene anabolism"], "types": ["T044"], "canonical_name": "down regulation of octadecene anabolism"}
{"concept_id": "C3545431", "aliases": ["down-regulation of 1-octadecene biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of 1-octadecene biosynthetic process"}
{"concept_id": "C3545432", "aliases": ["upregulation of olefin formation", "upregulation of olefin synthesis", "upregulation of olefin biosynthesis"], "types": ["T044"], "canonical_name": "upregulation of olefin anabolism"}
{"concept_id": "C3545433", "aliases": ["up-regulation of olefin synthesis"], "types": ["T044"], "canonical_name": "up regulation of olefin synthesis"}
{"concept_id": "C3545434", "aliases": ["up-regulation of olefin formation"], "types": ["T044"], "canonical_name": "up regulation of olefin formation"}
{"concept_id": "C3545435", "aliases": ["up-regulation of olefin biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of olefin biosynthesis"}
{"concept_id": "C3545436", "aliases": ["up-regulation of olefin anabolism"], "types": ["T044"], "canonical_name": "up regulation of olefin anabolism"}
{"concept_id": "C3545437", "aliases": ["positive regulation of olefin formation", "positive regulation of olefin biosynthesis", "positive regulation of olefin synthesis"], "types": ["T044"], "canonical_name": "positive regulation of olefin anabolism"}
{"concept_id": "C3545438", "aliases": ["activation of olefin biosynthesis", "activation of olefin biosynthetic process", "activation of olefin synthesis", "activation of olefin formation"], "types": ["T044"], "canonical_name": "activation of olefin anabolism"}
{"concept_id": "C3545439", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of olefin synthesis"}
{"concept_id": "C3545440", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of olefin formation"}
{"concept_id": "C3545441", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of olefin biosynthesis"}
{"concept_id": "C3545442", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of olefin anabolism"}
{"concept_id": "C3545443", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of olefin synthesis"}
{"concept_id": "C3545444", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of olefin biosynthetic process"}
{"concept_id": "C3545445", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of olefin biosynthesis"}
{"concept_id": "C3545446", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of olefin anabolism"}
{"concept_id": "C3545447", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of olefin synthesis"}
{"concept_id": "C3545448", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of olefin formation"}
{"concept_id": "C3545449", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of olefin biosynthesis"}
{"concept_id": "C3545450", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of olefin anabolism"}
{"concept_id": "C3545451", "aliases": ["down-regulation of olefin synthesis"], "types": ["T044"], "canonical_name": "down regulation of olefin synthesis"}
{"concept_id": "C3545452", "aliases": ["down-regulation of olefin formation"], "types": ["T044"], "canonical_name": "down regulation of olefin formation"}
{"concept_id": "C3545453", "aliases": ["down-regulation of olefin biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of olefin biosynthesis"}
{"concept_id": "C3545454", "aliases": ["down-regulation of olefin anabolism"], "types": ["T044"], "canonical_name": "down regulation of olefin anabolism"}
{"concept_id": "C3545455", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of olefin metabolism"}
{"concept_id": "C3545456", "aliases": ["up-regulation of olefin metabolism"], "types": ["T044"], "canonical_name": "up regulation of olefin metabolism"}
{"concept_id": "C3545457", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of olefin metabolism"}
{"concept_id": "C3545458", "aliases": [], "types": ["T044"], "canonical_name": "activation of olefin metabolism"}
{"concept_id": "C3545459", "aliases": [], "types": ["T044"], "canonical_name": "activation of olefin metabolic process"}
{"concept_id": "C3545460", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of olefin metabolism"}
{"concept_id": "C3545461", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of olefin metabolism"}
{"concept_id": "C3545462", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of olefin metabolic process"}
{"concept_id": "C3545463", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of olefin metabolism"}
{"concept_id": "C3545464", "aliases": ["down-regulation of olefin metabolism"], "types": ["T044"], "canonical_name": "down regulation of olefin metabolism"}
{"concept_id": "C3545465", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of hexadecanal metabolism"}
{"concept_id": "C3545466", "aliases": ["up-regulation of hexadecanal metabolism"], "types": ["T044"], "canonical_name": "up regulation of hexadecanal metabolism"}
{"concept_id": "C3545467", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of hexadecanal metabolism"}
{"concept_id": "C3545468", "aliases": [], "types": ["T044"], "canonical_name": "activation of hexadecanal metabolism"}
{"concept_id": "C3545469", "aliases": [], "types": ["T044"], "canonical_name": "activation of hexadecanal metabolic process"}
{"concept_id": "C3545470", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of hexadecanal metabolism"}
{"concept_id": "C3545471", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hexadecanal metabolism"}
{"concept_id": "C3545472", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hexadecanal metabolic process"}
{"concept_id": "C3545473", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of hexadecanal metabolism"}
{"concept_id": "C3545474", "aliases": ["down-regulation of hexadecanal metabolism"], "types": ["T044"], "canonical_name": "down regulation of hexadecanal metabolism"}
{"concept_id": "C3545475", "aliases": ["upregulation of palmitaldehyde biosynthetic process"], "types": ["T044"], "canonical_name": "upregulation of palmitaldehyde biosynthesis"}
{"concept_id": "C3545476", "aliases": ["upregulation of hexadecanal formation", "upregulation of hexadecanal biosynthesis", "upregulation of hexadecanal synthesis"], "types": ["T044"], "canonical_name": "upregulation of hexadecanal anabolism"}
{"concept_id": "C3545477", "aliases": ["up-regulation of palmitaldehyde biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of palmitaldehyde biosynthetic process"}
{"concept_id": "C3545478", "aliases": ["up-regulation of palmitaldehyde biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of palmitaldehyde biosynthesis"}
{"concept_id": "C3545479", "aliases": ["up-regulation of hexadecanal synthesis"], "types": ["T044"], "canonical_name": "up regulation of hexadecanal synthesis"}
{"concept_id": "C3545480", "aliases": ["up-regulation of hexadecanal formation"], "types": ["T044"], "canonical_name": "up regulation of hexadecanal formation"}
{"concept_id": "C3545481", "aliases": ["up-regulation of hexadecanal biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of hexadecanal biosynthesis"}
{"concept_id": "C3545482", "aliases": ["up-regulation of hexadecanal anabolism"], "types": ["T044"], "canonical_name": "up regulation of hexadecanal anabolism"}
{"concept_id": "C3545483", "aliases": ["positive regulation of palmitaldehyde biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of palmitaldehyde biosynthesis"}
{"concept_id": "C3545484", "aliases": ["positive regulation of hexadecanal synthesis", "positive regulation of hexadecanal biosynthesis", "positive regulation of hexadecanal formation"], "types": ["T044"], "canonical_name": "positive regulation of hexadecanal anabolism"}
{"concept_id": "C3545485", "aliases": ["activation of palmitaldehyde biosynthetic process"], "types": ["T044"], "canonical_name": "activation of palmitaldehyde biosynthesis"}
{"concept_id": "C3545486", "aliases": ["activation of hexadecanal biosynthetic process", "up regulation of hexadecanal biosynthetic process", "up-regulation of hexadecanal biosynthetic process", "activation of hexadecanal biosynthesis", "activation of hexadecanal anabolism", "activation of hexadecanal formation", "upregulation of hexadecanal biosynthetic process", "activation of hexadecanal synthesis"], "types": ["T044"], "canonical_name": "positive regulation of hexadecanal biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of hexadecanal biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545487", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of palmitaldehyde biosynthetic process"}
{"concept_id": "C3545488", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of palmitaldehyde biosynthesis"}
{"concept_id": "C3545489", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of hexadecanal synthesis"}
{"concept_id": "C3545490", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of hexadecanal formation"}
{"concept_id": "C3545491", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of hexadecanal biosynthesis"}
{"concept_id": "C3545492", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of hexadecanal anabolism"}
{"concept_id": "C3545493", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of palmitaldehyde biosynthetic process"}
{"concept_id": "C3545494", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of palmitaldehyde biosynthesis"}
{"concept_id": "C3545495", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hexadecanal synthesis"}
{"concept_id": "C3545496", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hexadecanal formation"}
{"concept_id": "C3545497", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hexadecanal biosynthetic process"}
{"concept_id": "C3545498", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hexadecanal biosynthesis"}
{"concept_id": "C3545499", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hexadecanal anabolism"}
{"concept_id": "C3545500", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of palmitaldehyde biosynthetic process"}
{"concept_id": "C3545501", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of palmitaldehyde biosynthesis"}
{"concept_id": "C3545502", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of hexadecanal synthesis"}
{"concept_id": "C3545503", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of hexadecanal formation"}
{"concept_id": "C3545504", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of hexadecanal biosynthesis"}
{"concept_id": "C3545505", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of hexadecanal anabolism"}
{"concept_id": "C3545506", "aliases": ["down-regulation of palmitaldehyde biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of palmitaldehyde biosynthetic process"}
{"concept_id": "C3545507", "aliases": ["down-regulation of palmitaldehyde biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of palmitaldehyde biosynthesis"}
{"concept_id": "C3545508", "aliases": ["down-regulation of hexadecanal synthesis"], "types": ["T044"], "canonical_name": "down regulation of hexadecanal synthesis"}
{"concept_id": "C3545509", "aliases": ["down-regulation of hexadecanal formation"], "types": ["T044"], "canonical_name": "down regulation of hexadecanal formation"}
{"concept_id": "C3545510", "aliases": ["down-regulation of hexadecanal biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of hexadecanal biosynthesis"}
{"concept_id": "C3545511", "aliases": ["down-regulation of hexadecanal anabolism"], "types": ["T044"], "canonical_name": "down regulation of hexadecanal anabolism"}
{"concept_id": "C3545512", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of heptadecane metabolism"}
{"concept_id": "C3545513", "aliases": ["up-regulation of heptadecane metabolism"], "types": ["T044"], "canonical_name": "up regulation of heptadecane metabolism"}
{"concept_id": "C3545514", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heptadecane metabolism"}
{"concept_id": "C3545515", "aliases": [], "types": ["T044"], "canonical_name": "activation of heptadecane metabolism"}
{"concept_id": "C3545516", "aliases": [], "types": ["T044"], "canonical_name": "activation of heptadecane metabolic process"}
{"concept_id": "C3545517", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of heptadecane metabolism"}
{"concept_id": "C3545518", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heptadecane metabolism"}
{"concept_id": "C3545519", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heptadecane metabolic process"}
{"concept_id": "C3545520", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of heptadecane metabolism"}
{"concept_id": "C3545521", "aliases": ["down-regulation of heptadecane metabolism"], "types": ["T044"], "canonical_name": "down regulation of heptadecane metabolism"}
{"concept_id": "C3545522", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of heptadecane synthesis"}
{"concept_id": "C3545523", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of heptadecane formation"}
{"concept_id": "C3545524", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of heptadecane biosynthesis"}
{"concept_id": "C3545525", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of heptadecane anabolism"}
{"concept_id": "C3545526", "aliases": ["up-regulation of heptadecane synthesis"], "types": ["T044"], "canonical_name": "up regulation of heptadecane synthesis"}
{"concept_id": "C3545527", "aliases": ["up-regulation of heptadecane formation"], "types": ["T044"], "canonical_name": "up regulation of heptadecane formation"}
{"concept_id": "C3545528", "aliases": ["up-regulation of heptadecane biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of heptadecane biosynthesis"}
{"concept_id": "C3545529", "aliases": ["up-regulation of heptadecane anabolism"], "types": ["T044"], "canonical_name": "up regulation of heptadecane anabolism"}
{"concept_id": "C3545530", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heptadecane synthesis"}
{"concept_id": "C3545531", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heptadecane formation"}
{"concept_id": "C3545532", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heptadecane biosynthesis"}
{"concept_id": "C3545533", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heptadecane anabolism"}
{"concept_id": "C3545534", "aliases": [], "types": ["T044"], "canonical_name": "activation of heptadecane synthesis"}
{"concept_id": "C3545535", "aliases": [], "types": ["T044"], "canonical_name": "activation of heptadecane formation"}
{"concept_id": "C3545536", "aliases": [], "types": ["T044"], "canonical_name": "activation of heptadecane biosynthetic process"}
{"concept_id": "C3545537", "aliases": [], "types": ["T044"], "canonical_name": "activation of heptadecane biosynthesis"}
{"concept_id": "C3545538", "aliases": [], "types": ["T044"], "canonical_name": "activation of heptadecane anabolism"}
{"concept_id": "C3545539", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of heptadecane synthesis"}
{"concept_id": "C3545540", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of heptadecane formation"}
{"concept_id": "C3545541", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of heptadecane biosynthesis"}
{"concept_id": "C3545542", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of heptadecane anabolism"}
{"concept_id": "C3545543", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heptadecane synthesis"}
{"concept_id": "C3545544", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heptadecane formation"}
{"concept_id": "C3545545", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heptadecane biosynthetic process"}
{"concept_id": "C3545546", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heptadecane biosynthesis"}
{"concept_id": "C3545547", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heptadecane anabolism"}
{"concept_id": "C3545548", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of heptadecane synthesis"}
{"concept_id": "C3545549", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of heptadecane formation"}
{"concept_id": "C3545550", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of heptadecane biosynthesis"}
{"concept_id": "C3545551", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of heptadecane anabolism"}
{"concept_id": "C3545552", "aliases": ["down-regulation of heptadecane synthesis"], "types": ["T044"], "canonical_name": "down regulation of heptadecane synthesis"}
{"concept_id": "C3545553", "aliases": ["down-regulation of heptadecane formation"], "types": ["T044"], "canonical_name": "down regulation of heptadecane formation"}
{"concept_id": "C3545554", "aliases": ["down-regulation of heptadecane biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of heptadecane biosynthesis"}
{"concept_id": "C3545555", "aliases": ["down-regulation of heptadecane anabolism"], "types": ["T044"], "canonical_name": "down regulation of heptadecane anabolism"}
{"concept_id": "C3545556", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of tridecane metabolism"}
{"concept_id": "C3545557", "aliases": ["up-regulation of tridecane metabolism"], "types": ["T044"], "canonical_name": "up regulation of tridecane metabolism"}
{"concept_id": "C3545558", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tridecane metabolism"}
{"concept_id": "C3545559", "aliases": [], "types": ["T044"], "canonical_name": "activation of tridecane metabolism"}
{"concept_id": "C3545560", "aliases": [], "types": ["T044"], "canonical_name": "activation of tridecane metabolic process"}
{"concept_id": "C3545561", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tridecane metabolism"}
{"concept_id": "C3545562", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tridecane metabolism"}
{"concept_id": "C3545563", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tridecane metabolic process"}
{"concept_id": "C3545564", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of tridecane metabolism"}
{"concept_id": "C3545565", "aliases": ["down-regulation of tridecane metabolism"], "types": ["T044"], "canonical_name": "down regulation of tridecane metabolism"}
{"concept_id": "C3545566", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of pentadecane metabolism"}
{"concept_id": "C3545567", "aliases": ["up-regulation of pentadecane metabolism"], "types": ["T044"], "canonical_name": "up regulation of pentadecane metabolism"}
{"concept_id": "C3545568", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pentadecane metabolism"}
{"concept_id": "C3545569", "aliases": [], "types": ["T044"], "canonical_name": "activation of pentadecane metabolism"}
{"concept_id": "C3545570", "aliases": [], "types": ["T044"], "canonical_name": "activation of pentadecane metabolic process"}
{"concept_id": "C3545571", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of pentadecane metabolism"}
{"concept_id": "C3545572", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pentadecane metabolism"}
{"concept_id": "C3545573", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pentadecane metabolic process"}
{"concept_id": "C3545574", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of pentadecane metabolism"}
{"concept_id": "C3545575", "aliases": ["down-regulation of pentadecane metabolism"], "types": ["T044"], "canonical_name": "down regulation of pentadecane metabolism"}
{"concept_id": "C3545576", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of pentadecane synthesis"}
{"concept_id": "C3545577", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of pentadecane formation"}
{"concept_id": "C3545578", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of pentadecane biosynthesis"}
{"concept_id": "C3545579", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of pentadecane anabolism"}
{"concept_id": "C3545580", "aliases": ["up-regulation of pentadecane synthesis"], "types": ["T044"], "canonical_name": "up regulation of pentadecane synthesis"}
{"concept_id": "C3545581", "aliases": ["up-regulation of pentadecane formation"], "types": ["T044"], "canonical_name": "up regulation of pentadecane formation"}
{"concept_id": "C3545582", "aliases": ["up-regulation of pentadecane biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of pentadecane biosynthesis"}
{"concept_id": "C3545583", "aliases": ["up-regulation of pentadecane anabolism"], "types": ["T044"], "canonical_name": "up regulation of pentadecane anabolism"}
{"concept_id": "C3545584", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pentadecane synthesis"}
{"concept_id": "C3545585", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pentadecane formation"}
{"concept_id": "C3545586", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pentadecane biosynthesis"}
{"concept_id": "C3545587", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pentadecane anabolism"}
{"concept_id": "C3545588", "aliases": [], "types": ["T044"], "canonical_name": "activation of pentadecane synthesis"}
{"concept_id": "C3545589", "aliases": [], "types": ["T044"], "canonical_name": "activation of pentadecane formation"}
{"concept_id": "C3545590", "aliases": [], "types": ["T044"], "canonical_name": "activation of pentadecane biosynthetic process"}
{"concept_id": "C3545591", "aliases": [], "types": ["T044"], "canonical_name": "activation of pentadecane biosynthesis"}
{"concept_id": "C3545592", "aliases": [], "types": ["T044"], "canonical_name": "activation of pentadecane anabolism"}
{"concept_id": "C3545593", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of pentadecane synthesis"}
{"concept_id": "C3545594", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of pentadecane formation"}
{"concept_id": "C3545595", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of pentadecane biosynthesis"}
{"concept_id": "C3545596", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of pentadecane anabolism"}
{"concept_id": "C3545597", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pentadecane synthesis"}
{"concept_id": "C3545598", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pentadecane formation"}
{"concept_id": "C3545599", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pentadecane biosynthetic process"}
{"concept_id": "C3545600", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pentadecane biosynthesis"}
{"concept_id": "C3545601", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pentadecane anabolism"}
{"concept_id": "C3545602", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of pentadecane synthesis"}
{"concept_id": "C3545603", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of pentadecane formation"}
{"concept_id": "C3545604", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of pentadecane biosynthesis"}
{"concept_id": "C3545605", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of pentadecane anabolism"}
{"concept_id": "C3545606", "aliases": ["down-regulation of pentadecane synthesis"], "types": ["T044"], "canonical_name": "down regulation of pentadecane synthesis"}
{"concept_id": "C3545607", "aliases": ["down-regulation of pentadecane formation"], "types": ["T044"], "canonical_name": "down regulation of pentadecane formation"}
{"concept_id": "C3545608", "aliases": ["down-regulation of pentadecane anabolism"], "types": ["T044"], "canonical_name": "down regulation of pentadecane anabolism"}
{"concept_id": "C3545609", "aliases": [], "types": ["T044"], "canonical_name": "activation of tridecane synthesis"}
{"concept_id": "C3545610", "aliases": [], "types": ["T044"], "canonical_name": "activation of tridecane formation"}
{"concept_id": "C3545611", "aliases": ["activation of tridecane biosynthetic process"], "types": ["T044"], "canonical_name": "activation of tridecane biosynthesis"}
{"concept_id": "C3545612", "aliases": [], "types": ["T044"], "canonical_name": "activation of tridecane anabolism"}
{"concept_id": "C3545613", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tridecane synthesis"}
{"concept_id": "C3545614", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tridecane formation"}
{"concept_id": "C3545615", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tridecane biosynthetic process"}
{"concept_id": "C3545616", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tridecane biosynthesis"}
{"concept_id": "C3545617", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tridecane anabolism"}
{"concept_id": "C3545618", "aliases": ["mRNA editing in chloroplast"], "types": ["T045"], "canonical_name": "chloroplast mRNA editing"}
{"concept_id": "C3545619", "aliases": [], "types": ["T045"], "canonical_name": "RNA editing in chloroplast"}
{"concept_id": "C3545620", "aliases": ["up regulation of cordyol C biosynthetic process", "upregulation of cordyol C biosynthetic process", "activation of cordyol C biosynthetic process", "up-regulation of cordyol C biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of cordyol C biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of cordyol C biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545621", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Lanosulin synthesis"}
{"concept_id": "C3545622", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Lanosulin formation"}
{"concept_id": "C3545623", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Lanosulin biosynthetic process"}
{"concept_id": "C3545624", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Lanosulin biosynthesis"}
{"concept_id": "C3545625", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Lanosulin anabolism"}
{"concept_id": "C3545626", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Pseurotin synthesis"}
{"concept_id": "C3545627", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Pseurotin formation"}
{"concept_id": "C3545628", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Pseurotin biosynthetic process"}
{"concept_id": "C3545629", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Pseurotin biosynthesis"}
{"concept_id": "C3545630", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Pseurotin anabolism"}
{"concept_id": "C3545631", "aliases": ["upregulation of naphtho-gamma-pyrone biosynthetic process", "up regulation of naphtho-gamma-pyrone biosynthetic process", "activation of naphtho-gamma-pyrone biosynthetic process", "up-regulation of naphtho-gamma-pyrone biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of naphtho-gamma-pyrone biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545632", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of naphtho-gamma-pyrone biosynthetic process"}
{"concept_id": "C3545638", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of fumigaclavine C biosynthetic process"}
{"concept_id": "C3545639", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Variecoxanthone B synthesis"}
{"concept_id": "C3545640", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Variecoxanthone B formation"}
{"concept_id": "C3545641", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Variecoxanthone B biosynthetic process"}
{"concept_id": "C3545642", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Variecoxanthone B biosynthesis"}
{"concept_id": "C3545643", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Variecoxanthone B anabolism"}
{"concept_id": "C3545646", "aliases": ["positive regulation of ergot alkaloid biosynthesis", "upregulation of ergot alkaloid synthesis", "upregulation of ergot alkaloid formation", "up-regulation of ergot alkaloid synthesis", "up regulation of ergot alkaloid biosynthesis", "up regulation of ergot alkaloid biosynthetic process", "positive regulation of ergot alkaloid formation", "activation of ergot alkaloid formation", "activation of ergot alkaloid biosynthesis", "up-regulation of ergot alkaloid anabolism", "up regulation of ergot alkaloid anabolism", "up-regulation of ergot alkaloid biosynthesis", "positive regulation of ergot alkaloid synthesis", "upregulation of ergot alkaloid anabolism", "activation of ergot alkaloid biosynthetic process", "up-regulation of ergot alkaloid biosynthetic process", "activation of ergot alkaloid anabolism", "up-regulation of ergot alkaloid formation", "up regulation of ergot alkaloid formation", "up regulation of ergot alkaloid synthesis", "upregulation of ergot alkaloid biosynthesis", "upregulation of ergot alkaloid biosynthetic process", "positive regulation of ergot alkaloid anabolism", "activation of ergot alkaloid synthesis"], "types": ["T044"], "canonical_name": "positive regulation of ergot alkaloid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of ergot alkaloid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545647", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ergot alkaloid biosynthetic process"}
{"concept_id": "C3545648", "aliases": ["Fumigacin synthesis", "Fumigacin biosynthesis", "Fumigacin formation", "Fumigacin biosynthetic process"], "types": ["T044"], "canonical_name": "Fumigacin anabolism"}
{"concept_id": "C3545649", "aliases": ["Fumigacin breakdown", "Fumigacin catabolic process", "Fumigacin degradation", "helvolic acid degradation", "helvolic acid breakdown", "Fumigacin catabolism", "helvolic acid catabolism"], "types": ["T044"], "canonical_name": "helvolic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of helvolic acid. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545650", "aliases": ["Fumigacin metabolic process", "Fumigacin metabolism", "helvolic acid metabolism"], "types": ["T044"], "canonical_name": "helvolic acid metabolic process", "definition": "The chemical reactions and pathways involving helvolic acid. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545652", "aliases": ["tryptophan-proline diketopiperazine formation", "tryptophan-proline diketopiperazine biosynthetic process", "tryptophan-proline diketopiperazine biosynthesis", "tryptophan-proline diketopiperazine synthesis"], "types": ["T044"], "canonical_name": "tryptophan-proline diketopiperazine anabolism"}
{"concept_id": "C3545653", "aliases": ["L-tryptophyl-L-proline cyclic anhydride biosynthetic process", "L-tryptophyl-L-proline cyclic anhydride formation", "L-tryptophyl-L-proline cyclic anhydride biosynthesis", "L-tryptophyl-L-proline cyclic anhydride synthesis"], "types": ["T044"], "canonical_name": "L-tryptophyl-L-proline cyclic anhydride anabolism"}
{"concept_id": "C3545654", "aliases": ["L-prolyl-L-tryptophan anhydride biosynthetic process", "L-prolyl-L-tryptophan anhydride formation", "L-prolyl-L-tryptophan anhydride biosynthesis", "L-prolyl-L-tryptophan anhydride synthesis"], "types": ["T044"], "canonical_name": "L-prolyl-L-tryptophan anhydride anabolism"}
{"concept_id": "C3545655", "aliases": ["cyclo-L-tryptophanyl-L-proline biosynthetic process", "cyclo-L-tryptophanyl-L-proline biosynthesis", "cyclo-L-tryptophanyl-L-proline formation", "cyclo-L-tryptophanyl-L-proline synthesis"], "types": ["T044"], "canonical_name": "cyclo-L-tryptophanyl-L-proline anabolism"}
{"concept_id": "C3545656", "aliases": ["cyclo-(Trp-Pro) synthesis", "cyclo-(Trp-Pro) biosynthesis", "cyclo-(Trp-Pro) formation", "cyclo-(Trp-Pro) biosynthetic process"], "types": ["T044"], "canonical_name": "cyclo-(Trp-Pro) anabolism"}
{"concept_id": "C3545657", "aliases": ["C16H17N3O2 biosynthetic process", "C16H17N3O2 formation", "C16H17N3O2 synthesis", "C16H17N3O2 biosynthesis"], "types": ["T044"], "canonical_name": "C16H17N3O2 anabolism"}
{"concept_id": "C3545658", "aliases": ["tryptophan-proline diketopiperazine catabolism", "tryptophan-proline diketopiperazine degradation", "tryptophan-proline diketopiperazine catabolic process"], "types": ["T044"], "canonical_name": "tryptophan-proline diketopiperazine breakdown"}
{"concept_id": "C3545659", "aliases": ["L-tryptophyl-L-proline cyclic anhydride degradation", "L-tryptophyl-L-proline cyclic anhydride catabolism", "L-tryptophyl-L-proline cyclic anhydride catabolic process"], "types": ["T044"], "canonical_name": "L-tryptophyl-L-proline cyclic anhydride breakdown"}
{"concept_id": "C3545660", "aliases": ["L-prolyl-L-tryptophan anhydride catabolic process", "L-prolyl-L-tryptophan anhydride degradation", "L-prolyl-L-tryptophan anhydride catabolism"], "types": ["T044"], "canonical_name": "L-prolyl-L-tryptophan anhydride breakdown"}
{"concept_id": "C3545661", "aliases": ["cyclo-L-tryptophanyl-L-proline catabolic process", "cyclo-L-tryptophanyl-L-proline catabolism", "cyclo-L-tryptophanyl-L-proline degradation"], "types": ["T044"], "canonical_name": "cyclo-L-tryptophanyl-L-proline breakdown"}
{"concept_id": "C3545662", "aliases": ["cyclo-(Trp-Pro) degradation", "cyclo-(Trp-Pro) catabolic process", "cyclo-(Trp-Pro) catabolism"], "types": ["T044"], "canonical_name": "cyclo-(Trp-Pro) breakdown"}
{"concept_id": "C3545663", "aliases": ["tryptophan-proline diketopiperazine metabolism"], "types": ["T044"], "canonical_name": "tryptophan-proline diketopiperazine metabolic process"}
{"concept_id": "C3545664", "aliases": ["L-tryptophyl-L-proline cyclic anhydride metabolism"], "types": ["T044"], "canonical_name": "L-tryptophyl-L-proline cyclic anhydride metabolic process"}
{"concept_id": "C3545665", "aliases": ["L-prolyl-L-tryptophan anhydride metabolism"], "types": ["T044"], "canonical_name": "L-prolyl-L-tryptophan anhydride metabolic process"}
{"concept_id": "C3545666", "aliases": ["cyclo-L-tryptophanyl-L-proline metabolic process", "cyclo-L-tryptophanyl-L-proline metabolism", "cyclo-L-Trp-L-Pro metabolism"], "types": ["T044"], "canonical_name": "cyclo-L-Trp-L-Pro metabolic process"}
{"concept_id": "C3545667", "aliases": [], "types": ["T044"], "canonical_name": "cyclo-(Trp-Pro) metabolism"}
{"concept_id": "C3545668", "aliases": ["Pseurotin synthesis", "Pseurotin biosynthetic process", "Pseurotin biosynthesis", "Pseurotin formation"], "types": ["T044"], "canonical_name": "Pseurotin anabolism"}
{"concept_id": "C3545669", "aliases": ["Pseurotin catabolic process", "Pseurotin catabolism", "Pseurotin degradation"], "types": ["T044"], "canonical_name": "Pseurotin breakdown"}
{"concept_id": "C3545670", "aliases": ["Pseurotin metabolism"], "types": ["T044"], "canonical_name": "Pseurotin metabolic process"}
{"concept_id": "C3545676", "aliases": ["Lanosulin synthesis", "Lanosulin biosynthesis", "Lanosulin formation", "Lanosulin biosynthetic process"], "types": ["T044"], "canonical_name": "Lanosulin anabolism"}
{"concept_id": "C3545677", "aliases": ["Lanosulin catabolic process", "Lanosulin degradation", "Lanosulin catabolism"], "types": ["T044"], "canonical_name": "Lanosulin breakdown"}
{"concept_id": "C3545678", "aliases": ["Lanosulin metabolism", "fumitremorgin B metabolism", "Lanosulin metabolic process"], "types": ["T044"], "canonical_name": "fumitremorgin B metabolic process", "definition": "The chemical reactions and pathways involving fumitremorgin B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545679", "aliases": ["Variecoxanthone B synthesis", "Variecoxanthone B biosynthesis", "Variecoxanthone B biosynthetic process", "Variecoxanthone B formation"], "types": ["T044"], "canonical_name": "Variecoxanthone B anabolism"}
{"concept_id": "C3545680", "aliases": ["Variecoxanthone B catabolic process", "Variecoxanthone B degradation", "Variecoxanthone B catabolism"], "types": ["T044"], "canonical_name": "Variecoxanthone B breakdown"}
{"concept_id": "C3545681", "aliases": ["Variecoxanthone B metabolism"], "types": ["T044"], "canonical_name": "Variecoxanthone B metabolic process"}
{"concept_id": "C3545682", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sterigmatocystin biosynthetic process"}
{"concept_id": "C3545683", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of new yellow enzyme"}
{"concept_id": "C3545684", "aliases": ["up-regulation of new yellow enzyme"], "types": ["T044"], "canonical_name": "up regulation of new yellow enzyme"}
{"concept_id": "C3545685", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of new yellow enzyme"}
{"concept_id": "C3545686", "aliases": [], "types": ["T044"], "canonical_name": "activation of new yellow enzyme"}
{"concept_id": "C3545687", "aliases": [], "types": ["T044"], "canonical_name": "activation of D-amino-acid oxidase activity"}
{"concept_id": "C3545688", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of new yellow enzyme"}
{"concept_id": "C3545689", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of new yellow enzyme"}
{"concept_id": "C3545690", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of D-amino-acid oxidase activity"}
{"concept_id": "C3545691", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of new yellow enzyme"}
{"concept_id": "C3545692", "aliases": ["down-regulation of new yellow enzyme"], "types": ["T044"], "canonical_name": "down regulation of new yellow enzyme"}
{"concept_id": "C3545693", "aliases": [], "types": ["T044"], "canonical_name": "regulation of new yellow enzyme"}
{"concept_id": "C3545694", "aliases": ["protein maturation by proteolysis in phagosome"], "types": ["T044"], "canonical_name": "protein maturation by proteolysis in phagocytic vesicle"}
{"concept_id": "C3545695", "aliases": ["peptidolysis during protein maturation in phagosome"], "types": ["T044"], "canonical_name": "peptidolysis during protein maturation in phagocytic vesicle"}
{"concept_id": "C3545696", "aliases": [], "types": ["T043"], "canonical_name": "doxorubicinum transport"}
{"concept_id": "C3545698", "aliases": [], "types": ["T043"], "canonical_name": "Adriamycin transport"}
{"concept_id": "C3545699", "aliases": [], "types": ["T043"], "canonical_name": "14-hydroxydaunorubicine transport"}
{"concept_id": "C3545700", "aliases": [], "types": ["T043"], "canonical_name": "14-hydroxydaunomycin transport"}
{"concept_id": "C3545701", "aliases": [], "types": ["T043"], "canonical_name": "(8S-cis)-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione transport"}
{"concept_id": "C3545702", "aliases": [], "types": ["T043"], "canonical_name": "(1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport"}
{"concept_id": "C3545703", "aliases": ["H2malo transport", "propanedioic acid transport", "HOOC-CH2-COOH transport", "C3H4O4 transport"], "types": ["T043"], "canonical_name": "malonic acid transport", "definition": "The directed movement of a malonic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie, PMID:9128730, PMID:9573154]"}
{"concept_id": "C3545704", "aliases": [], "types": ["T044"], "canonical_name": "deoxycarnitine transport"}
{"concept_id": "C3545705", "aliases": [], "types": ["T044"], "canonical_name": "C7H15NO2 transport"}
{"concept_id": "C3545706", "aliases": [], "types": ["T044"], "canonical_name": "butyrobetaine transport"}
{"concept_id": "C3545707", "aliases": [], "types": ["T044"], "canonical_name": "Actinine transport"}
{"concept_id": "C3545708", "aliases": ["oligopeptido binding", "Oligopeptid binding", "oligopeptides binding"], "types": ["T044"], "canonical_name": "oligopeptide binding", "definition": "Binding to an oligopeptide. [GOC:TermGenie, PMID:21854595]"}
{"concept_id": "C3545709", "aliases": [], "types": ["T043"], "canonical_name": "Levocarnitine transport"}
{"concept_id": "C3545710", "aliases": [], "types": ["T043"], "canonical_name": "Carnitor transport"}
{"concept_id": "C3545711", "aliases": [], "types": ["T043"], "canonical_name": "Carnitene transport"}
{"concept_id": "C3545712", "aliases": [], "types": ["T043"], "canonical_name": "Carnicor transport"}
{"concept_id": "C3545713", "aliases": [], "types": ["T043"], "canonical_name": "C7H15NO3 transport"}
{"concept_id": "C3545715", "aliases": [], "types": ["T043"], "canonical_name": "(-)-Carnitine transport"}
{"concept_id": "C3545716", "aliases": ["activation of VEGF-activated signaling pathway", "activation of VEGF signaling"], "types": ["T044"], "canonical_name": "activation of vascular endothelial growth factor signaling pathway"}
{"concept_id": "C3545718", "aliases": [], "types": ["T040"], "canonical_name": "activation of p38MAPK cascade"}
{"concept_id": "C3545719", "aliases": [], "types": ["T040"], "canonical_name": "activation of filamentous growth of a population of unicellular organisms in response to pH"}
{"concept_id": "C3545720", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of filamentous growth of a population of unicellular organisms in response to pH"}
{"concept_id": "C3545721", "aliases": ["up-regulation of protein insertion into mitochondrial membrane during induction of apoptosis", "up-regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis", "upregulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis", "up regulation of protein insertion into mitochondrion membrane during induction of apoptosis", "upregulation of protein insertion into mitochondrial membrane during induction of apoptosis", "up regulation of protein insertion into mitochondrial membrane during induction of apoptosis", "up regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis", "up-regulation of protein insertion into mitochondrion membrane during induction of apoptosis", "positive regulation of protein insertion into mitochondrial membrane during induction of apoptosis", "positive regulation of protein insertion into mitochondrion membrane during induction of apoptosis", "upregulation of protein insertion into mitochondrion membrane during induction of apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis"}
{"concept_id": "C3545722", "aliases": ["up-regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis", "up regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis", "upregulation of protein insertion into mitochondrial membrane involved in induction of apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis"}
{"concept_id": "C3545723", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein insertion into mitochondrion membrane during induction of apoptosis"}
{"concept_id": "C3545724", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein insertion into mitochondrial membrane involved in induction of apoptosis"}
{"concept_id": "C3545725", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway"}
{"concept_id": "C3545726", "aliases": ["activation of protein insertion into mitochondrial membrane during induction of apoptosis"], "types": ["T043"], "canonical_name": "activation of insertion of proteins into mitochondrial membranes during the induction of apoptosis"}
{"concept_id": "C3545727", "aliases": [], "types": ["T039"], "canonical_name": "regulation of protein insertion into mitochondrion membrane during induction of apoptosis"}
{"concept_id": "C3545728", "aliases": [], "types": ["T039"], "canonical_name": "regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis"}
{"concept_id": "C3545729", "aliases": ["regulation of protein insertion into mitochondrial membrane during induction of apoptosis"], "types": ["T044"], "canonical_name": "regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis"}
{"concept_id": "C3545730", "aliases": ["up regulation of phospholipase C-activating dopamine receptor signaling pathway", "up-regulation of phospholipase C-activating dopamine receptor signaling pathway"], "types": ["T043"], "canonical_name": "upregulation of phospholipase C-activating dopamine receptor signaling pathway"}
{"concept_id": "C3545731", "aliases": ["up-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger", "up regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger"], "types": ["T043"], "canonical_name": "upregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger"}
{"concept_id": "C3545732", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of phospholipase C-activating dopamine receptor signaling pathway"}
{"concept_id": "C3545733", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger"}
{"concept_id": "C3545734", "aliases": [], "types": ["T043"], "canonical_name": "activation of phospholipase C-activating G-protein coupled receptor signaling pathway"}
{"concept_id": "C3545735", "aliases": [], "types": ["T043"], "canonical_name": "activation of phospholipase C-activating dopamine receptor signaling pathway"}
{"concept_id": "C3545736", "aliases": [], "types": ["T043"], "canonical_name": "activation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger"}
{"concept_id": "C3545737", "aliases": ["down regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger", "negative regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger", "down-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger"], "types": ["T043"], "canonical_name": "downregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger"}
{"concept_id": "C3545738", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of phospholipase C-activating G-protein coupled receptor signaling pathway"}
{"concept_id": "C3545739", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of phospholipase C-activating dopamine receptor signaling pathway"}
{"concept_id": "C3545740", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger"}
{"concept_id": "C3545741", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of phospholipase C-activating dopamine receptor signaling pathway"}
{"concept_id": "C3545742", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phospholipase C-activating dopamine receptor signaling pathway"}
{"concept_id": "C3545743", "aliases": [], "types": ["T043"], "canonical_name": "regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger"}
{"concept_id": "C3545744", "aliases": [], "types": ["T038"], "canonical_name": "activation of flocculation"}
{"concept_id": "C3545745", "aliases": ["activation of polyketide formation", "up-regulation of polyketide biosynthetic process", "up regulation of polyketide biosynthesis", "upregulation of polyketide formation", "positive regulation of polyketide formation", "up regulation of polyketide anabolism", "activation of polyketide anabolism", "upregulation of polyketide synthesis", "up regulation of polyketide formation", "positive regulation of polyketide biosynthesis", "up regulation of polyketide biosynthetic process", "activation of polyketide biosynthetic process", "positive regulation of polyketide synthesis", "up regulation of polyketide synthesis", "activation of polyketide synthesis", "activation of polyketide biosynthesis", "upregulation of polyketide biosynthetic process", "up-regulation of polyketide biosynthesis", "upregulation of polyketide biosynthesis", "up-regulation of polyketide formation", "up-regulation of polyketide anabolism", "positive regulation of polyketide anabolism", "upregulation of polyketide anabolism", "up-regulation of polyketide synthesis"], "types": ["T044"], "canonical_name": "positive regulation of polyketide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of polyketide biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545746", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polyketide biosynthetic process"}
{"concept_id": "C3545747", "aliases": [], "types": ["T043"], "canonical_name": "activation of opioid receptor-mediated adenylate cyclase inhibition"}
{"concept_id": "C3545748", "aliases": [], "types": ["T043"], "canonical_name": "activation of adenylate cyclase-inhibiting opioid receptor signaling pathway"}
{"concept_id": "C3545749", "aliases": ["negative regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway"], "types": ["T043"], "canonical_name": "negative regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway"}
{"concept_id": "C3545750", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of opioid receptor-mediated adenylate cyclase inhibition"}
{"concept_id": "C3545751", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adenylate cyclase-inhibiting opioid receptor signaling pathway"}
{"concept_id": "C3545752", "aliases": [], "types": ["T043"], "canonical_name": "regulation of opioid receptor-mediated adenylate cyclase inhibition"}
{"concept_id": "C3545753", "aliases": ["regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway"], "types": ["T043"], "canonical_name": "regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway"}
{"concept_id": "C3545754", "aliases": [], "types": ["T043"], "canonical_name": "regulation of inhibition of adenylate cyclase activity by opioid receptor"}
{"concept_id": "C3545755", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein adenylylation"}
{"concept_id": "C3545756", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein adenylylation"}
{"concept_id": "C3545757", "aliases": [], "types": ["T039"], "canonical_name": "activation of uterine smooth muscle relaxation"}
{"concept_id": "C3545758", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of uterine smooth muscle relaxation"}
{"concept_id": "C3545759", "aliases": ["activation of violaceol II biosynthesis", "activation of violaceol II formation", "positive regulation of violaceol II biosynthesis", "up-regulation of violaceol II biosynthesis", "up regulation of violaceol II formation", "up regulation of violaceol II biosynthesis", "activation of violaceol II biosynthetic process", "upregulation of violaceol II formation", "positive regulation of violaceol II anabolism", "positive regulation of violaceol II synthesis", "upregulation of violaceol II biosynthetic process", "up-regulation of violaceol II anabolism", "up regulation of violaceol II synthesis", "up regulation of violaceol II biosynthetic process", "upregulation of violaceol II biosynthesis", "up-regulation of violaceol II biosynthetic process", "up-regulation of violaceol II synthesis", "positive regulation of violaceol II formation", "up-regulation of violaceol II formation", "upregulation of violaceol II synthesis", "upregulation of violaceol II anabolism", "up regulation of violaceol II anabolism", "activation of violaceol II anabolism", "activation of violaceol II synthesis"], "types": ["T044"], "canonical_name": "positive regulation of violaceol II biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of violaceol II biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545760", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of violaceol II biosynthetic process"}
{"concept_id": "C3545761", "aliases": ["positive regulation of violaceol I formation", "activation of violaceol I synthesis", "up regulation of violaceol I anabolism", "up regulation of violaceol I biosynthetic process", "activation of violaceol I anabolism", "activation of violaceol I formation", "positive regulation of violaceol I synthesis", "upregulation of violaceol I anabolism", "upregulation of violaceol I biosynthetic process", "up regulation of violaceol I formation", "upregulation of violaceol I synthesis", "up-regulation of violaceol I anabolism", "up regulation of violaceol I synthesis", "upregulation of violaceol I formation", "up-regulation of violaceol I formation", "up-regulation of violaceol I biosynthesis", "positive regulation of violaceol I biosynthesis", "activation of violaceol I biosynthesis", "up-regulation of violaceol I biosynthetic process", "up-regulation of violaceol I synthesis", "activation of violaceol I biosynthetic process", "upregulation of violaceol I biosynthesis", "positive regulation of violaceol I anabolism", "up regulation of violaceol I biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of violaceol I biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of violaceol I biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545762", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of violaceol I biosynthetic process"}
{"concept_id": "C3545763", "aliases": ["activation of tensidol B formation", "up regulation of tensidol B synthesis", "up-regulation of tensidol B anabolism", "up regulation of tensidol B formation", "activation of tensidol B biosynthetic process", "activation of tensidol B biosynthesis", "up-regulation of tensidol B formation", "positive regulation of tensidol B biosynthesis", "up regulation of tensidol B biosynthetic process", "upregulation of tensidol B biosynthesis", "upregulation of tensidol B formation", "positive regulation of tensidol B formation", "up regulation of tensidol B anabolism", "activation of tensidol B anabolism", "up regulation of tensidol B biosynthesis", "positive regulation of tensidol B anabolism", "up-regulation of tensidol B biosynthetic process", "up-regulation of tensidol B synthesis", "positive regulation of tensidol B synthesis", "upregulation of tensidol B synthesis", "activation of tensidol B synthesis", "upregulation of tensidol B anabolism", "up-regulation of tensidol B biosynthesis", "upregulation of tensidol B biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of tensidol B biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of tensidol B biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545764", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tensidol B biosynthetic process"}
{"concept_id": "C3545765", "aliases": ["up regulation of tensidol A biosynthesis", "up-regulation of tensidol A synthesis", "upregulation of tensidol A biosynthesis", "up-regulation of tensidol A biosynthesis", "up regulation of tensidol A formation", "activation of tensidol A anabolism", "activation of tensidol A formation", "positive regulation of tensidol A formation", "activation of tensidol A synthesis", "upregulation of tensidol A formation", "up-regulation of tensidol A anabolism", "activation of tensidol A biosynthetic process", "up regulation of tensidol A anabolism", "upregulation of tensidol A biosynthetic process", "up-regulation of tensidol A formation", "up-regulation of tensidol A biosynthetic process", "positive regulation of tensidol A synthesis", "up regulation of tensidol A synthesis", "positive regulation of tensidol A biosynthesis", "activation of tensidol A biosynthesis", "positive regulation of tensidol A anabolism", "upregulation of tensidol A anabolism", "upregulation of tensidol A synthesis", "up regulation of tensidol A biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of tensidol A biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of tensidol A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545766", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tensidol A biosynthetic process"}
{"concept_id": "C3545767", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of siderophore biosynthetic process, peptide modification"}
{"concept_id": "C3545768", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of siderophore biosynthetic process, peptide formation"}
{"concept_id": "C3545769", "aliases": ["upregulation of siderochrome biosynthetic process"], "types": ["T044"], "canonical_name": "upregulation of siderochrome biosynthesis"}
{"concept_id": "C3545770", "aliases": ["up-regulation of siderophore biosynthetic process, peptide modification"], "types": ["T044"], "canonical_name": "up regulation of siderophore biosynthetic process, peptide modification"}
{"concept_id": "C3545771", "aliases": ["up-regulation of siderophore biosynthetic process, peptide formation"], "types": ["T044"], "canonical_name": "up regulation of siderophore biosynthetic process, peptide formation"}
{"concept_id": "C3545772", "aliases": ["up-regulation of siderochrome biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of siderochrome biosynthetic process"}
{"concept_id": "C3545773", "aliases": ["up-regulation of siderochrome biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of siderochrome biosynthesis"}
{"concept_id": "C3545774", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of siderophore biosynthetic process, peptide modification"}
{"concept_id": "C3545775", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of siderophore biosynthetic process, peptide formation"}
{"concept_id": "C3545776", "aliases": ["positive regulation of siderochrome biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of siderochrome biosynthesis"}
{"concept_id": "C3545777", "aliases": [], "types": ["T044"], "canonical_name": "activation of siderophore biosynthetic process, peptide modification"}
{"concept_id": "C3545778", "aliases": [], "types": ["T044"], "canonical_name": "activation of siderophore biosynthetic process, peptide formation"}
{"concept_id": "C3545779", "aliases": [], "types": ["T044"], "canonical_name": "activation of siderophore biosynthetic process"}
{"concept_id": "C3545780", "aliases": ["activation of siderochrome biosynthetic process"], "types": ["T044"], "canonical_name": "activation of siderochrome biosynthesis"}
{"concept_id": "C3545781", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of siderophore biosynthetic process, peptide modification"}
{"concept_id": "C3545782", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of siderophore biosynthetic process, peptide formation"}
{"concept_id": "C3545783", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of siderochrome biosynthetic process"}
{"concept_id": "C3545784", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of siderochrome biosynthesis"}
{"concept_id": "C3545785", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of siderophore biosynthetic process, peptide modification"}
{"concept_id": "C3545786", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of siderophore biosynthetic process, peptide formation"}
{"concept_id": "C3545787", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of siderophore biosynthetic process"}
{"concept_id": "C3545788", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of siderochrome biosynthetic process"}
{"concept_id": "C3545789", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of siderochrome biosynthesis"}
{"concept_id": "C3545790", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of siderophore biosynthetic process, peptide modification"}
{"concept_id": "C3545791", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of siderophore biosynthetic process, peptide formation"}
{"concept_id": "C3545792", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of siderochrome biosynthetic process"}
{"concept_id": "C3545793", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of siderochrome biosynthesis"}
{"concept_id": "C3545794", "aliases": ["down-regulation of siderophore biosynthetic process, peptide modification"], "types": ["T044"], "canonical_name": "down regulation of siderophore biosynthetic process, peptide modification"}
{"concept_id": "C3545795", "aliases": ["down-regulation of siderophore biosynthetic process, peptide formation"], "types": ["T044"], "canonical_name": "down regulation of siderophore biosynthetic process, peptide formation"}
{"concept_id": "C3545796", "aliases": ["down-regulation of siderochrome biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of siderochrome biosynthetic process"}
{"concept_id": "C3545797", "aliases": ["down-regulation of siderochrome biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of siderochrome biosynthesis"}
{"concept_id": "C3545798", "aliases": [], "types": ["T044"], "canonical_name": "regulation of siderophore biosynthetic process, peptide modification"}
{"concept_id": "C3545799", "aliases": [], "types": ["T044"], "canonical_name": "regulation of siderophore biosynthetic process, peptide formation"}
{"concept_id": "C3545800", "aliases": [], "types": ["T044"], "canonical_name": "regulation of siderochrome biosynthetic process"}
{"concept_id": "C3545801", "aliases": [], "types": ["T044"], "canonical_name": "regulation of siderochrome biosynthesis"}
{"concept_id": "C3545802", "aliases": ["up regulation of orcinol formation", "up-regulation of orcinol formation", "activation of orcinol formation", "up-regulation of orcinol biosynthetic process", "positive regulation of orcinol biosynthesis", "upregulation of orcinol formation", "activation of orcinol anabolism", "upregulation of orcinol biosynthesis", "upregulation of orcinol biosynthetic process", "up regulation of orcinol synthesis", "positive regulation of orcinol formation", "positive regulation of orcinol anabolism", "upregulation of orcinol anabolism", "activation of orcinol biosynthesis", "up regulation of orcinol anabolism", "up-regulation of orcinol synthesis", "up regulation of orcinol biosynthetic process", "up-regulation of orcinol anabolism", "positive regulation of orcinol synthesis", "activation of orcinol synthesis", "activation of orcinol biosynthetic process", "upregulation of orcinol synthesis", "up-regulation of orcinol biosynthesis", "up regulation of orcinol biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of orcinol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of orcinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545803", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of orcinol biosynthetic process"}
{"concept_id": "C3545804", "aliases": ["up-regulation of o-orsellinic acid biosynthetic process", "upregulation of o-orsellinic acid anabolism", "up regulation of o-orsellinic acid anabolism", "up-regulation of o-orsellinic acid formation", "activation of o-orsellinic acid formation", "positive regulation of o-orsellinic acid synthesis", "up-regulation of o-orsellinic acid synthesis", "up-regulation of o-orsellinic acid anabolism", "positive regulation of o-orsellinic acid anabolism", "upregulation of o-orsellinic acid formation", "activation of o-orsellinic acid anabolism", "upregulation of o-orsellinic acid biosynthetic process", "activation of o-orsellinic acid synthesis", "upregulation of o-orsellinic acid synthesis", "positive regulation of o-orsellinic acid formation", "up regulation of o-orsellinic acid biosynthetic process", "activation of o-orsellinic acid biosynthesis", "up regulation of o-orsellinic acid formation", "upregulation of o-orsellinic acid biosynthesis", "up regulation of o-orsellinic acid biosynthesis", "up regulation of o-orsellinic acid synthesis", "up-regulation of o-orsellinic acid biosynthesis", "positive regulation of o-orsellinic acid biosynthesis", "activation of o-orsellinic acid biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of o-orsellinic acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of o-orsellinic acid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545805", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of o-orsellinic acid biosynthetic process"}
{"concept_id": "C3545806", "aliases": [], "types": ["T044"], "canonical_name": "activation of N',N'',N'''-triacetylfusarinine C biosynthetic process"}
{"concept_id": "C3545807", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of N',N'',N'''-triacetylfusarinine C biosynthetic process"}
{"concept_id": "C3545808", "aliases": ["up regulation of (+)-kotanin biosynthetic process", "positive regulation of (+)-kotanin formation", "up-regulation of (+)-kotanin anabolism", "positive regulation of (+)-kotanin anabolism", "up regulation of (+)-kotanin anabolism", "up-regulation of (+)-kotanin synthesis", "activation of (+)-kotanin synthesis", "activation of (+)-kotanin anabolism", "upregulation of (+)-kotanin anabolism", "up-regulation of (+)-kotanin biosynthesis", "activation of (+)-kotanin biosynthesis", "upregulation of (+)-kotanin biosynthetic process", "positive regulation of (+)-kotanin biosynthesis", "activation of (+)-kotanin biosynthetic process", "up regulation of (+)-kotanin synthesis", "activation of (+)-kotanin formation", "upregulation of (+)-kotanin synthesis", "upregulation of (+)-kotanin biosynthesis", "up-regulation of (+)-kotanin formation", "positive regulation of (+)-kotanin synthesis", "up-regulation of (+)-kotanin biosynthetic process", "upregulation of (+)-kotanin formation", "up regulation of (+)-kotanin formation", "up regulation of (+)-kotanin biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of (+)-kotanin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of (+)-kotanin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545809", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of (+)-kotanin biosynthetic process"}
{"concept_id": "C3545810", "aliases": ["upregulation of gliotoxin anabolism", "up-regulation of gliotoxin biosynthetic process", "up regulation of gliotoxin biosynthetic process", "up-regulation of gliotoxin anabolism", "activation of gliotoxin anabolism", "activation of gliotoxin biosynthesis", "positive regulation of gliotoxin synthesis", "upregulation of gliotoxin biosynthetic process", "up regulation of gliotoxin formation", "up-regulation of gliotoxin formation", "upregulation of gliotoxin formation", "up regulation of gliotoxin biosynthesis", "positive regulation of gliotoxin biosynthesis", "activation of gliotoxin synthesis", "positive regulation of gliotoxin formation", "activation of gliotoxin biosynthetic process", "activation of gliotoxin formation", "up-regulation of gliotoxin biosynthesis", "positive regulation of gliotoxin anabolism", "upregulation of gliotoxin synthesis", "up regulation of gliotoxin anabolism", "up-regulation of gliotoxin synthesis", "upregulation of gliotoxin biosynthesis", "up regulation of gliotoxin synthesis"], "types": ["T044"], "canonical_name": "positive regulation of gliotoxin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of gliotoxin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545811", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of gliotoxin biosynthetic process"}
{"concept_id": "C3545812", "aliases": ["upregulation of gerfelin synthesis", "up regulation of gerfelin anabolism", "up-regulation of gerfelin synthesis", "activation of gerfelin synthesis", "positive regulation of gerfelin biosynthesis", "positive regulation of gerfelin synthesis", "up-regulation of gerfelin formation", "upregulation of gerfelin biosynthetic process", "up regulation of gerfelin formation", "activation of gerfelin formation", "upregulation of gerfelin biosynthesis", "activation of gerfelin anabolism", "positive regulation of gerfelin formation", "up-regulation of gerfelin biosynthesis", "activation of gerfelin biosynthesis", "positive regulation of gerfelin anabolism", "upregulation of gerfelin formation", "activation of gerfelin biosynthetic process", "up-regulation of gerfelin biosynthetic process", "up-regulation of gerfelin anabolism", "up regulation of gerfelin biosynthetic process", "up regulation of gerfelin synthesis", "upregulation of gerfelin anabolism", "up regulation of gerfelin biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of gerfelin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of gerfelin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545813", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of gerfelin biosynthetic process"}
{"concept_id": "C3545814", "aliases": ["up regulation of fumonisin anabolism", "positive regulation of fumonisin biosynthesis", "up regulation of fumonisin formation", "up-regulation of fumonisin biosynthetic process", "up regulation of fumonisin biosynthesis", "upregulation of fumonisin biosynthesis", "up-regulation of fumonisin formation", "positive regulation of fumonisin formation", "upregulation of fumonisin formation", "upregulation of fumonisin synthesis", "upregulation of fumonisin anabolism", "activation of fumonisin synthesis", "activation of fumonisin biosynthesis", "positive regulation of fumonisin anabolism", "activation of fumonisin biosynthetic process", "positive regulation of fumonisin synthesis", "activation of fumonisin formation", "up regulation of fumonisin biosynthetic process", "activation of fumonisin anabolism", "upregulation of fumonisin biosynthetic process", "up-regulation of fumonisin biosynthesis", "up regulation of fumonisin synthesis", "up-regulation of fumonisin synthesis", "up-regulation of fumonisin anabolism"], "types": ["T044"], "canonical_name": "positive regulation of fumonisin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of fumonisin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545815", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of fumonisin biosynthetic process"}
{"concept_id": "C3545816", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C3545817", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C3545818", "aliases": ["up-regulation of ferricrocin biosynthetic process, peptide modification"], "types": ["T044"], "canonical_name": "up regulation of ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C3545819", "aliases": ["up-regulation of ferricrocin biosynthetic process, peptide formation"], "types": ["T044"], "canonical_name": "up regulation of ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C3545820", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C3545821", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C3545822", "aliases": [], "types": ["T044"], "canonical_name": "activation of ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C3545823", "aliases": [], "types": ["T044"], "canonical_name": "activation of ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C3545824", "aliases": [], "types": ["T044"], "canonical_name": "activation of ferricrocin biosynthetic process"}
{"concept_id": "C3545825", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C3545826", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C3545827", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C3545828", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C3545829", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ferricrocin biosynthetic process"}
{"concept_id": "C3545830", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C3545831", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C3545832", "aliases": ["down-regulation of ferricrocin biosynthetic process, peptide modification"], "types": ["T044"], "canonical_name": "down regulation of ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C3545833", "aliases": ["down-regulation of ferricrocin biosynthetic process, peptide formation"], "types": ["T044"], "canonical_name": "down regulation of ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C3545834", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ferricrocin biosynthetic process, peptide modification"}
{"concept_id": "C3545835", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ferricrocin biosynthetic process, peptide formation"}
{"concept_id": "C3545836", "aliases": [], "types": ["T044"], "canonical_name": "activation of F-9775B biosynthetic process"}
{"concept_id": "C3545837", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of F-9775B biosynthetic process"}
{"concept_id": "C3545838", "aliases": [], "types": ["T044"], "canonical_name": "activation of F-9775A biosynthetic process"}
{"concept_id": "C3545839", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of F-9775A biosynthetic process"}
{"concept_id": "C3545840", "aliases": ["upregulation of endocrocin synthesis", "up-regulation of endocrocin synthesis", "up regulation of endocrocin biosynthetic process", "positive regulation of endocrocin anabolism", "activation of endocrocin biosynthetic process", "upregulation of endocrocin anabolism", "up regulation of endocrocin anabolism", "up-regulation of endocrocin anabolism", "upregulation of endocrocin biosynthetic process", "up regulation of endocrocin synthesis", "activation of endocrocin synthesis", "activation of endocrocin formation", "upregulation of endocrocin formation", "activation of endocrocin anabolism", "up-regulation of endocrocin formation", "up-regulation of endocrocin biosynthetic process", "positive regulation of endocrocin synthesis", "up-regulation of endocrocin biosynthesis", "activation of endocrocin biosynthesis", "positive regulation of endocrocin biosynthesis", "up regulation of endocrocin biosynthesis", "up regulation of endocrocin formation", "upregulation of endocrocin biosynthesis", "positive regulation of endocrocin formation"], "types": ["T044"], "canonical_name": "positive regulation of endocrocin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of endocrocin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545841", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of endocrocin biosynthetic process"}
{"concept_id": "C3545842", "aliases": ["activation of emodin synthesis", "activation of emodin formation", "up regulation of emodin biosynthetic process", "up-regulation of emodin biosynthesis", "upregulation of emodin formation", "up regulation of emodin formation", "up-regulation of emodin synthesis", "upregulation of emodin biosynthetic process", "positive regulation of emodin biosynthesis", "positive regulation of emodin anabolism", "up regulation of emodin synthesis", "up-regulation of emodin biosynthetic process", "upregulation of emodin biosynthesis", "up regulation of emodin biosynthesis", "activation of emodin anabolism", "up-regulation of emodin formation", "activation of emodin biosynthetic process", "upregulation of emodin anabolism", "upregulation of emodin synthesis", "activation of emodin biosynthesis", "positive regulation of emodin formation", "up-regulation of emodin anabolism", "positive regulation of emodin synthesis", "up regulation of emodin anabolism"], "types": ["T044"], "canonical_name": "positive regulation of emodin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of emodin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545843", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of emodin biosynthetic process"}
{"concept_id": "C3545844", "aliases": [], "types": ["T044"], "canonical_name": "activation of emericellamide A biosynthetic process"}
{"concept_id": "C3545845", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of emericellamide A biosynthetic process"}
{"concept_id": "C3545846", "aliases": ["up regulation of emericellamide formation", "positive regulation of emericellamide anabolism", "activation of emericellamide anabolism", "up-regulation of emericellamide biosynthesis", "up-regulation of emericellamide biosynthetic process", "up-regulation of emericellamide anabolism", "activation of emericellamide biosynthesis", "positive regulation of emericellamide biosynthesis", "up-regulation of emericellamide synthesis", "upregulation of emericellamide anabolism", "upregulation of emericellamide synthesis", "positive regulation of emericellamide formation", "upregulation of emericellamide biosynthesis", "up regulation of emericellamide anabolism", "up-regulation of emericellamide formation", "upregulation of emericellamide formation", "upregulation of emericellamide biosynthetic process", "up regulation of emericellamide synthesis", "activation of emericellamide synthesis", "up regulation of emericellamide biosynthetic process", "activation of emericellamide biosynthetic process", "activation of emericellamide formation", "positive regulation of emericellamide synthesis", "up regulation of emericellamide biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of emericellamide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of emericellamide biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545847", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of emericellamide biosynthetic process"}
{"concept_id": "C3545848", "aliases": ["activation of diorcinol formation", "up-regulation of diorcinol biosynthetic process", "up regulation of diorcinol biosynthetic process", "positive regulation of diorcinol biosynthesis", "positive regulation of diorcinol formation", "up regulation of diorcinol synthesis", "up-regulation of diorcinol biosynthesis", "activation of diorcinol anabolism", "up-regulation of diorcinol synthesis", "activation of diorcinol biosynthesis", "up-regulation of diorcinol anabolism", "up-regulation of diorcinol formation", "up regulation of diorcinol anabolism", "upregulation of diorcinol biosynthetic process", "up regulation of diorcinol formation", "positive regulation of diorcinol anabolism", "activation of diorcinol synthesis", "upregulation of diorcinol anabolism", "upregulation of diorcinol synthesis", "upregulation of diorcinol biosynthesis", "positive regulation of diorcinol synthesis", "activation of diorcinol biosynthetic process", "up regulation of diorcinol biosynthesis", "upregulation of diorcinol formation"], "types": ["T044"], "canonical_name": "positive regulation of diorcinol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of diorcinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545849", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of diorcinol biosynthetic process"}
{"concept_id": "C3545850", "aliases": ["activation of demethylkotanin biosynthesis", "up regulation of demethylkotanin biosynthetic process", "upregulation of demethylkotanin biosynthesis", "upregulation of demethylkotanin biosynthetic process", "activation of demethylkotanin formation", "upregulation of demethylkotanin anabolism", "positive regulation of demethylkotanin formation", "upregulation of demethylkotanin synthesis", "up-regulation of demethylkotanin biosynthetic process", "up regulation of demethylkotanin biosynthesis", "positive regulation of demethylkotanin synthesis", "up regulation of demethylkotanin anabolism", "activation of demethylkotanin anabolism", "activation of demethylkotanin biosynthetic process", "up-regulation of demethylkotanin synthesis", "up-regulation of demethylkotanin biosynthesis", "up-regulation of demethylkotanin formation", "up-regulation of demethylkotanin anabolism", "activation of demethylkotanin synthesis", "positive regulation of demethylkotanin biosynthesis", "up regulation of demethylkotanin synthesis", "upregulation of demethylkotanin formation", "positive regulation of demethylkotanin anabolism", "up regulation of demethylkotanin formation"], "types": ["T044"], "canonical_name": "positive regulation of demethylkotanin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of demethylkotanin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545851", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of demethylkotanin biosynthetic process"}
{"concept_id": "C3545852", "aliases": [], "types": ["T044"], "canonical_name": "activation of dehydroaustinol biosynthetic process"}
{"concept_id": "C3545853", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of dehydroaustinol biosynthetic process"}
{"concept_id": "C3545854", "aliases": [], "types": ["T044"], "canonical_name": "activation of chanoclavine-I aldehyde biosynthetic process"}
{"concept_id": "C3545855", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of chanoclavine-I aldehyde biosynthetic process"}
{"concept_id": "C3545856", "aliases": [], "types": ["T044"], "canonical_name": "activation of chanoclavine-I biosynthetic process"}
{"concept_id": "C3545857", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of chanoclavine-I biosynthetic process"}
{"concept_id": "C3545858", "aliases": ["up regulation of austinol biosynthetic process", "activation of austinol formation", "upregulation of austinol anabolism", "upregulation of austinol biosynthetic process", "up regulation of austinol synthesis", "up-regulation of austinol biosynthesis", "up-regulation of austinol formation", "up-regulation of austinol synthesis", "positive regulation of austinol formation", "up-regulation of austinol anabolism", "positive regulation of austinol synthesis", "activation of austinol biosynthetic process", "positive regulation of austinol biosynthesis", "up-regulation of austinol biosynthetic process", "upregulation of austinol biosynthesis", "activation of austinol anabolism", "activation of austinol synthesis", "upregulation of austinol synthesis", "up regulation of austinol anabolism", "positive regulation of austinol anabolism", "up regulation of austinol biosynthesis", "upregulation of austinol formation", "activation of austinol biosynthesis", "up regulation of austinol formation"], "types": ["T044"], "canonical_name": "positive regulation of austinol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of austinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3545859", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of austinol biosynthetic process"}
{"concept_id": "C3545860", "aliases": [], "types": ["T044"], "canonical_name": "activation of asperfuranone biosynthetic process"}
{"concept_id": "C3545861", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of asperfuranone biosynthetic process"}
{"concept_id": "C3545862", "aliases": [], "types": ["T044"], "canonical_name": "activation of arugosin biosynthetic process"}
{"concept_id": "C3545863", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of arugosin biosynthetic process"}
{"concept_id": "C3545864", "aliases": [], "types": ["T043"], "canonical_name": "activation of monocyte aggregation"}
{"concept_id": "C3545865", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of monocyte aggregation"}
{"concept_id": "C3545866", "aliases": [], "types": ["T045"], "canonical_name": "calcineurin-mediated activation of transcription"}
{"concept_id": "C3545867", "aliases": ["calcineurin-dependent transcriptional induction"], "types": ["T045"], "canonical_name": "calcineurin-dependent transcription activation"}
{"concept_id": "C3545876", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of purine metabolism"}
{"concept_id": "C3545877", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of purine metabolic process"}
{"concept_id": "C3545878", "aliases": ["up-regulation of purine metabolism"], "types": ["T043"], "canonical_name": "up regulation of purine metabolism"}
{"concept_id": "C3545879", "aliases": ["up-regulation of purine metabolic process"], "types": ["T043"], "canonical_name": "up regulation of purine metabolic process"}
{"concept_id": "C3545880", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of purine metabolism"}
{"concept_id": "C3545881", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of purine metabolic process"}
{"concept_id": "C3545882", "aliases": [], "types": ["T044"], "canonical_name": "activation of purine nucleotide metabolism"}
{"concept_id": "C3545883", "aliases": [], "types": ["T044"], "canonical_name": "activation of purine nucleotide metabolic process"}
{"concept_id": "C3545884", "aliases": [], "types": ["T044"], "canonical_name": "activation of purine metabolism"}
{"concept_id": "C3545885", "aliases": [], "types": ["T044"], "canonical_name": "activation of purine metabolic process"}
{"concept_id": "C3545886", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of purine metabolism"}
{"concept_id": "C3545887", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of purine metabolic process"}
{"concept_id": "C3545888", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of purine nucleotide metabolism"}
{"concept_id": "C3545889", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of purine nucleotide metabolic process"}
{"concept_id": "C3545890", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of purine metabolism"}
{"concept_id": "C3545891", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of purine metabolic process"}
{"concept_id": "C3545892", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of purine metabolism"}
{"concept_id": "C3545893", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of purine metabolic process"}
{"concept_id": "C3545894", "aliases": ["down-regulation of purine metabolism"], "types": ["T043"], "canonical_name": "down regulation of purine metabolism"}
{"concept_id": "C3545895", "aliases": ["down-regulation of purine metabolic process"], "types": ["T043"], "canonical_name": "down regulation of purine metabolic process"}
{"concept_id": "C3545896", "aliases": [], "types": ["T044"], "canonical_name": "regulation of purine metabolism"}
{"concept_id": "C3545897", "aliases": [], "types": ["T044"], "canonical_name": "regulation of purine metabolic process"}
{"concept_id": "C3545898", "aliases": ["fumonisin degradation", "fumonisin breakdown", "fumonisin catabolism"], "types": ["T044"], "canonical_name": "fumonisin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fumonisin. [GOC:TermGenie]"}
{"concept_id": "C3545899", "aliases": ["fumonisin metabolism"], "types": ["T044"], "canonical_name": "fumonisin metabolic process", "definition": "The chemical reactions and pathways involving fumonisin. [GOC:TermGenie]"}
{"concept_id": "C3545906", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to amylopectin"}
{"concept_id": "C3545907", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to amylopectin"}
{"concept_id": "C3545908", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to pullulan"}
{"concept_id": "C3545909", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of response to pullulan"}
{"concept_id": "C3545910", "aliases": [], "types": ["T044"], "canonical_name": "activation of xylose catabolic process to ethanol"}
{"concept_id": "C3545911", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of xylose catabolic process to ethanol"}
{"concept_id": "C3545914", "aliases": ["up-regulation of pentose catabolic process to ethanol", "positive regulation of pentose catabolism to ethanol", "up regulation of pentose catabolism to ethanol", "up regulation of pentose catabolic process to ethanol", "up-regulation of pentose catabolism to ethanol", "activation of pentose catabolism to ethanol", "activation of pentose catabolic process to ethanol", "upregulation of pentose catabolism to ethanol", "upregulation of pentose catabolic process to ethanol"], "types": ["T044"], "canonical_name": "positive regulation of pentose catabolic process to ethanol", "definition": "Any process that activates or increases the frequency, rate or extent of pentose catabolic process to ethanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545915", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pentose catabolic process to ethanol"}
{"concept_id": "C3545916", "aliases": ["activation of iron molybdenum cofactor biosynthesis", "up-regulation of iron molybdenum cofactor assembly", "up regulation of iron-sulfur-molybdenum cofactor assembly", "positive regulation of iron molybdenum cofactor biosynthetic process", "activation of FeMoco biosynthetic process", "up-regulation of iron-sulfur-molybdenum cofactor assembly", "up regulation of FeMoco biosynthetic process", "activation of iron molybdenum cofactor biosynthetic process", "upregulation of iron-sulfur-molybdenum cofactor assembly", "positive regulation of FeMoco biosynthetic process", "upregulation of FeMoco assembly", "up regulation of FeMoco assembly", "upregulation of iron molybdenum cofactor biosynthesis", "up-regulation of iron molybdenum cofactor biosynthesis", "up regulation of iron molybdenum cofactor assembly", "up regulation of iron molybdenum cofactor biosynthetic process", "positive regulation of iron molybdenum cofactor biosynthesis", "up regulation of iron molybdenum cofactor biosynthesis", "positive regulation of iron molybdenum cofactor assembly", "up-regulation of FeMoco assembly", "activation of iron-sulfur-molybdenum cofactor assembly", "upregulation of iron molybdenum cofactor assembly", "activation of FeMoco assembly", "upregulation of iron molybdenum cofactor biosynthetic process", "up-regulation of iron molybdenum cofactor biosynthetic process", "activation of iron molybdenum cofactor assembly", "up-regulation of FeMoco biosynthetic process", "upregulation of FeMoco biosynthetic process", "positive regulation of FeMoco assembly"], "types": ["T044"], "canonical_name": "positive regulation of iron-sulfur-molybdenum cofactor assembly", "definition": "Any process that activates or increases the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545917", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of iron-sulfur-molybdenum cofactor assembly"}
{"concept_id": "C3545918", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellulosome assembly"}
{"concept_id": "C3545919", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellulosome assembly"}
{"concept_id": "C3545920", "aliases": ["up regulation of butyryl-CoA catabolism to butyrate", "upregulation of butyryl-CoA catabolism to butyrate", "up-regulation of butyryl-CoA catabolism to butyrate", "upregulation of butyryl-CoA catabolic process to butyrate", "up regulation of butyryl-CoA catabolic process to butyrate", "activation of butyryl-CoA catabolic process to butyrate", "up-regulation of butyryl-CoA catabolic process to butyrate", "positive regulation of butyryl-CoA catabolism to butyrate", "activation of butyryl-CoA catabolism to butyrate"], "types": ["T044"], "canonical_name": "positive regulation of butyryl-CoA catabolic process to butyrate", "definition": "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butyrate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545921", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of butyryl-CoA catabolic process to butyrate"}
{"concept_id": "C3545922", "aliases": ["positive regulation of butyryl-CoA catabolism to butanol", "activation of butyryl-CoA catabolic process to butanol", "up-regulation of butyryl-CoA catabolism to butanol", "activation of butyryl-CoA catabolism to butanol", "up regulation of butyryl-CoA catabolism to butanol", "upregulation of butyryl-CoA catabolic process to butanol", "up regulation of butyryl-CoA catabolic process to butanol", "up-regulation of butyryl-CoA catabolic process to butanol", "upregulation of butyryl-CoA catabolism to butanol"], "types": ["T044"], "canonical_name": "positive regulation of butyryl-CoA catabolic process to butanol", "definition": "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545923", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of butyryl-CoA catabolic process to butanol"}
{"concept_id": "C3545924", "aliases": ["up-regulation of butyryl-CoA biosynthesis from acetyl-CoA", "positive regulation of butyryl-CoA biosynthesis from acetyl-CoA", "up regulation of butyryl-CoA biosynthesis from acetyl-CoA", "up regulation of butyryl-CoA biosynthetic process from acetyl-CoA", "upregulation of butyryl-CoA biosynthesis from acetyl-CoA", "upregulation of butyryl-CoA biosynthetic process from acetyl-CoA", "activation of butyryl-CoA biosynthetic process from acetyl-CoA", "activation of butyryl-CoA biosynthesis from acetyl-CoA", "up-regulation of butyryl-CoA biosynthetic process from acetyl-CoA"], "types": ["T044"], "canonical_name": "positive regulation of butyryl-CoA biosynthetic process from acetyl-CoA", "definition": "Any process that activates or increases the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3545925", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of butyryl-CoA biosynthetic process from acetyl-CoA"}
{"concept_id": "C3545926", "aliases": ["up-regulation of [4Fe-4S] cluster biosynthetic process", "upregulation of [4Fe-4S] cluster biosynthetic process", "positive regulation of [4Fe-4S] cluster biosynthetic process", "up regulation of [4Fe-4S] cluster biosynthetic process"], "types": ["T044"], "canonical_name": "activation of [4Fe-4S] cluster biosynthetic process"}
{"concept_id": "C3545927", "aliases": ["activation of [4Fe-4S] cluster assembly", "up-regulation of 4Fe-4S cluster assembly", "up regulation of [4Fe-4S] cluster assembly", "upregulation of 4Fe-4S cluster assembly", "up-regulation of [4Fe-4S] cluster assembly", "positive regulation of 4Fe-4S cluster assembly", "upregulation of [4Fe-4S] cluster assembly", "activation of 4Fe-4S cluster assembly", "up regulation of 4Fe-4S cluster assembly"], "types": ["T044"], "canonical_name": "positive regulation of [4Fe-4S] cluster assembly", "definition": "Any process that activates or increases the frequency, rate or extent of [4Fe-4S] cluster assembly. [GOC:mengo_curators, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3545928", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of [4Fe-4S] cluster biosynthetic process"}
{"concept_id": "C3545929", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of [4Fe-4S] cluster biosynthetic process"}
{"concept_id": "C3545930", "aliases": ["inhibition of 4Fe-4S cluster assembly"], "types": ["T044"], "canonical_name": "inhibition of [4Fe-4S] cluster assembly"}
{"concept_id": "C3545931", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of [4Fe-4S] cluster biosynthetic process"}
{"concept_id": "C3545932", "aliases": ["down-regulation of [4Fe-4S] cluster biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of [4Fe-4S] cluster biosynthetic process"}
{"concept_id": "C3545933", "aliases": ["regulation of [4Fe-4S] cluster biosynthetic process", "regulation of 4Fe-4S cluster assembly"], "types": ["T044"], "canonical_name": "regulation of [4Fe-4S] cluster assembly", "definition": "Any process that modulates the frequency, rate or extent of [4Fe-4S] cluster assembly. [GOC:mengo_curators, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3545943", "aliases": ["upregulation of [2Fe-2S] cluster assembly", "up regulation of 2Fe-2S cluster assembly", "up-regulation of 2Fe-2S cluster assembly", "upregulation of 2Fe-2S cluster assembly", "upregulation of [2Fe-2S] cluster biosynthetic process", "positive regulation of [2Fe-2S] cluster biosynthetic process", "up-regulation of [2Fe-2S] cluster assembly", "activation of [2Fe-2S] cluster biosynthetic process", "positive regulation of 2Fe-2S cluster assembly", "up regulation of [2Fe-2S] cluster assembly"], "types": ["T044"], "canonical_name": "positive regulation of [2Fe-2S] cluster assembly", "definition": "Any process that activates or increases the frequency, rate or extent of [2Fe-2S] cluster assembly. [GOC:mengo_curators, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3545944", "aliases": ["up-regulation of [2Fe-2S] cluster biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of [2Fe-2S] cluster biosynthetic process"}
{"concept_id": "C3545945", "aliases": ["activation of 2Fe-2S cluster assembly"], "types": ["T044"], "canonical_name": "activation of [2Fe-2S] cluster assembly"}
{"concept_id": "C3545946", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of [2Fe-2S] cluster biosynthetic process"}
{"concept_id": "C3545947", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of [2Fe-2S] cluster biosynthetic process"}
{"concept_id": "C3545948", "aliases": ["inhibition of 2Fe-2S cluster assembly"], "types": ["T044"], "canonical_name": "inhibition of [2Fe-2S] cluster assembly"}
{"concept_id": "C3545949", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of [2Fe-2S] cluster biosynthetic process"}
{"concept_id": "C3545950", "aliases": ["down-regulation of [2Fe-2S] cluster biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of [2Fe-2S] cluster biosynthetic process"}
{"concept_id": "C3545951", "aliases": ["regulation of [2Fe-2S] cluster biosynthetic process", "regulation of 2Fe-2S cluster assembly"], "types": ["T044"], "canonical_name": "regulation of [2Fe-2S] cluster assembly", "definition": "Any process that modulates the frequency, rate or extent of [2Fe-2S] cluster assembly. [GOC:mengo_curators, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3545952", "aliases": [], "types": ["T044"], "canonical_name": "activation of isopentenyl diphosphate biosynthetic process, mevalonate pathway"}
{"concept_id": "C3545953", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein targeting to vacuolar membrane"}
{"concept_id": "C3545954", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein targeting to vacuolar membrane"}
{"concept_id": "C3545955", "aliases": ["up-regulation of diacylglycerol anabolism", "upregulation of diacylglycerol formation", "up-regulation of diacylglycerol synthesis", "positive regulation of diacylglycerol biosynthesis", "activation of diacylglycerol formation", "positive regulation of diacylglycerol anabolism", "up regulation of diacylglycerol synthesis", "up-regulation of diacylglycerol biosynthetic process", "positive regulation of diacylglycerol formation", "up-regulation of diacylglycerol formation", "up-regulation of diacylglycerol biosynthesis", "activation of diacylglycerol synthesis", "up regulation of diacylglycerol biosynthetic process", "up regulation of diacylglycerol anabolism", "positive regulation of diacylglycerol synthesis", "upregulation of diacylglycerol biosynthesis", "up regulation of diacylglycerol formation", "upregulation of diacylglycerol anabolism", "up regulation of diacylglycerol biosynthesis", "activation of diacylglycerol anabolism", "activation of diacylglycerol biosynthesis", "activation of diacylglycerol biosynthetic process", "upregulation of diacylglycerol synthesis", "upregulation of diacylglycerol biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of diacylglycerol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of diacylglycerol biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3545956", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of diacylglycerol biosynthetic process"}
{"concept_id": "C3545957", "aliases": [], "types": ["T043"], "canonical_name": "activation of flocculation via cell wall protein-carbohydrate interaction"}
{"concept_id": "C3545965", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C3545966", "aliases": [], "types": ["T045"], "canonical_name": "activation of meiosis by negative regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C3545969", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylserine biosynthetic process"}
{"concept_id": "C3545970", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylserine biosynthetic process"}
{"concept_id": "C3545973", "aliases": [], "types": ["T044"], "canonical_name": "activation of brassinosteroid mediated signaling pathway"}
{"concept_id": "C3545974", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of brassinosteroid mediated signaling pathway"}
{"concept_id": "C3545975", "aliases": ["up regulation of LTD", "up-regulation of LTD"], "types": ["T044"], "canonical_name": "upregulation of LTD"}
{"concept_id": "C3545976", "aliases": ["up regulation of long term depression", "up-regulation of long term depression"], "types": ["T044"], "canonical_name": "upregulation of long term depression"}
{"concept_id": "C3545977", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of LTD"}
{"concept_id": "C3545978", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of long term depression"}
{"concept_id": "C3545979", "aliases": [], "types": ["T039"], "canonical_name": "activation of LTD"}
{"concept_id": "C3545980", "aliases": [], "types": ["T044"], "canonical_name": "activation of long term synaptic depression"}
{"concept_id": "C3545981", "aliases": [], "types": ["T044"], "canonical_name": "activation of long term depression"}
{"concept_id": "C3545982", "aliases": ["down regulation of LTD", "negative regulation of LTD", "down-regulation of long term depression", "down regulation of long term depression", "negative regulation of long term depression", "downregulation of LTD", "down-regulation of LTD"], "types": ["T044"], "canonical_name": "downregulation of long term depression"}
{"concept_id": "C3545983", "aliases": ["inhibition of LTD"], "types": ["T038"], "canonical_name": "inhibition of long term depression"}
{"concept_id": "C3545984", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of long term synaptic depression"}
{"concept_id": "C3545985", "aliases": ["regulation of long term depression", "regulation of long term synaptic depression", "regulation of LTD"], "types": ["T042"], "canonical_name": "regulation of long-term synaptic depression", "definition": "Any process that modulates the frequency, rate or extent of long term synaptic depression. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3545986", "aliases": [], "types": ["T044"], "canonical_name": "activation of glutamate receptor signaling pathway"}
{"concept_id": "C3545987", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glutamate receptor signaling pathway"}
{"concept_id": "C3545988", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cell shape and cell size of phenotypic switching"}
{"concept_id": "C3545989", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cell shape and cell size of phenotypic dimorphism"}
{"concept_id": "C3545990", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cell morphogenesis of phenotypic dimorphism"}
{"concept_id": "C3545991", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of cell shape and cell size of phenotypic switching"}
{"concept_id": "C3545992", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of cell shape and cell size of phenotypic dimorphism"}
{"concept_id": "C3545993", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of cell shape and cell size of phenotypic switching"}
{"concept_id": "C3545994", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of cell shape and cell size of phenotypic dimorphism"}
{"concept_id": "C3545996", "aliases": [], "types": ["T040"], "canonical_name": "activation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"}
{"concept_id": "C3545997", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of filamentous growth of a population of unicellular organisms in response to biotic stimulus"}
{"concept_id": "C3545998", "aliases": [], "types": ["T040"], "canonical_name": "activation of filamentous growth of a population of unicellular organisms in response to neutral pH"}
{"concept_id": "C3545999", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of filamentous growth of a population of unicellular organisms in response to neutral pH"}
{"concept_id": "C3546000", "aliases": [], "types": ["T040"], "canonical_name": "activation of filamentous growth of a population of unicellular organisms in response to chemical stimulus"}
{"concept_id": "C3546001", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of filamentous growth of a population of unicellular organisms in response to chemical stimulus"}
{"concept_id": "C3546002", "aliases": [], "types": ["T040"], "canonical_name": "activation of filamentous growth of a population of unicellular organisms in response to starvation"}
{"concept_id": "C3546004", "aliases": [], "types": ["T040"], "canonical_name": "activation of filamentous growth of a population of unicellular organisms in response to heat"}
{"concept_id": "C3546005", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of filamentous growth of a population of unicellular organisms in response to heat"}
{"concept_id": "C3546006", "aliases": [], "types": ["T040"], "canonical_name": "activation of filamentous growth of a population of unicellular organisms"}
{"concept_id": "C3546007", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of filamentous growth of a population of unicellular organisms"}
{"concept_id": "C3546009", "aliases": ["up-regulation of antibacterial peptide activity", "up regulation of antibacterial peptide activity"], "types": ["T044"], "canonical_name": "upregulation of antibacterial peptide activity"}
{"concept_id": "C3546010", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of antibacterial peptide activity"}
{"concept_id": "C3546012", "aliases": [], "types": ["T044"], "canonical_name": "activation of antibacterial peptide activity"}
{"concept_id": "C3546013", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of antibacterial peptide activity"}
{"concept_id": "C3546015", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of antibacterial peptide activity"}
{"concept_id": "C3546016", "aliases": ["down-regulation of antibacterial peptide activity", "down regulation of antibacterial peptide activity"], "types": ["T044"], "canonical_name": "downregulation of antibacterial peptide activity"}
{"concept_id": "C3546017", "aliases": [], "types": ["T044"], "canonical_name": "regulation of antibacterial peptide activity"}
{"concept_id": "C3546021", "aliases": [], "types": ["T044"], "canonical_name": "activation of cellular alcohol catabolic process"}
{"concept_id": "C3546022", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cellular alcohol catabolic process"}
{"concept_id": "C3546025", "aliases": ["up-regulation of adaptive response to oxidative stress", "up regulation of adaptive response to oxidative stress"], "types": ["T043"], "canonical_name": "upregulation of adaptive response to oxidative stress"}
{"concept_id": "C3546026", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of adaptive response to oxidative stress"}
{"concept_id": "C3546027", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to oxidative stress"}
{"concept_id": "C3546028", "aliases": [], "types": ["T043"], "canonical_name": "activation of adaptive response to oxidative stress"}
{"concept_id": "C3546029", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of adaptive response to oxidative stress"}
{"concept_id": "C3546030", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to oxidative stress"}
{"concept_id": "C3546031", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adaptive response to oxidative stress"}
{"concept_id": "C3546032", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of adaptive response to oxidative stress"}
{"concept_id": "C3546033", "aliases": ["down-regulation of adaptive response to oxidative stress"], "types": ["T043"], "canonical_name": "down regulation of adaptive response to oxidative stress"}
{"concept_id": "C3546034", "aliases": [], "types": ["T043"], "canonical_name": "regulation of adaptive response to oxidative stress"}
{"concept_id": "C3546036", "aliases": ["upregulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter", "activation of DNA repair by positive regulation of transcription from RNA polymerase II promoter", "stimulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter", "up-regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter", "up regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "positive regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter", "definition": "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of DNA repair. [GOC:mah, GOC:TermGenie, PMID:20299455]"}
{"concept_id": "C3546037", "aliases": ["positive regulation of pyrimidine nucleotide biosynthesis", "upregulation of pyrimidine nucleotide formation", "activation of pyrimidine nucleotide synthesis", "up-regulation of pyrimidine nucleotide formation", "upregulation of pyrimidine nucleotide anabolism", "up-regulation of pyrimidine nucleotide biosynthesis", "activation of pyrimidine nucleotide anabolism", "up regulation of pyrimidine nucleotide biosynthesis", "upregulation of pyrimidine nucleotide synthesis", "activation of pyrimidine nucleotide biosynthesis", "up-regulation of pyrimidine nucleotide synthesis", "up-regulation of pyrimidine nucleotide anabolism", "positive regulation of pyrimidine nucleotide synthesis", "up regulation of pyrimidine nucleotide formation", "up regulation of pyrimidine nucleotide synthesis", "up regulation of pyrimidine nucleotide biosynthetic process", "activation of pyrimidine nucleotide formation", "upregulation of pyrimidine nucleotide biosynthetic process", "positive regulation of pyrimidine nucleotide formation", "upregulation of pyrimidine nucleotide biosynthesis", "positive regulation of pyrimidine nucleotide anabolism", "activation of pyrimidine nucleotide biosynthetic process", "up regulation of pyrimidine nucleotide anabolism", "up-regulation of pyrimidine nucleotide biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of pyrimidine nucleotide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of pyrimidine nucleotide biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3546038", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pyrimidine nucleotide biosynthetic process"}
{"concept_id": "C3546039", "aliases": ["up-regulation of C6H6O4 formation", "up regulation of C6H6O4 biosynthetic process", "upregulation of C6H6O4 formation", "upregulation of C6H6O4 biosynthetic process", "up-regulation of C6H6O4 biosynthesis", "up-regulation of C6H6O4 synthesis", "positive regulation of C6H6O4 biosynthesis", "up regulation of C6H6O4 formation", "activation of C6H6O4 synthesis", "positive regulation of C6H6O4 anabolism", "up regulation of C6H6O4 anabolism", "upregulation of C6H6O4 synthesis", "up-regulation of C6H6O4 anabolism", "activation of C6H6O4 formation", "positive regulation of C6H6O4 synthesis", "positive regulation of C6H6O4 biosynthetic process", "activation of C6H6O4 biosynthesis", "upregulation of C6H6O4 anabolism", "up-regulation of C6H6O4 biosynthetic process", "positive regulation of C6H6O4 formation", "up regulation of C6H6O4 synthesis", "upregulation of C6H6O4 biosynthesis", "up regulation of C6H6O4 biosynthesis", "activation of C6H6O4 biosynthetic process"], "types": ["T044"], "canonical_name": "activation of C6H6O4 anabolism"}
{"concept_id": "C3546040", "aliases": ["up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "upregulation of kojic acid biosynthesis", "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "activation of kojic acid biosynthesis", "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "up-regulation of kojic acid formation", "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "up-regulation of kojic acid biosynthesis", "up regulation of kojic acid formation", "upregulation of kojic acid formation", "activation of kojic acid biosynthetic process", "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "activation of kojic acid synthesis", "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "up-regulation of kojic acid synthesis", "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "up-regulation of kojic acid biosynthetic process", "activation of kojic acid formation", "up regulation of kojic acid biosynthetic process", "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "up regulation of kojic acid anabolism", "positive regulation of kojic acid formation", "positive regulation of kojic acid synthesis", "up-regulation of kojic acid anabolism", "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "positive regulation of kojic acid anabolism", "activation of kojic acid anabolism", "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "upregulation of kojic acid synthesis", "positive regulation of kojic acid biosynthesis", "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "up regulation of kojic acid synthesis", "up regulation of kojic acid biosynthesis", "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "upregulation of kojic acid biosynthetic process", "upregulation of kojic acid anabolism", "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of kojic acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of kojic acid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3546041", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of C6H6O4 synthesis"}
{"concept_id": "C3546042", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of C6H6O4 formation"}
{"concept_id": "C3546043", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of C6H6O4 biosynthetic process"}
{"concept_id": "C3546044", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of C6H6O4 biosynthesis"}
{"concept_id": "C3546045", "aliases": ["negative regulation of C6H6O4 anabolism", "down regulation of C6H6O4 anabolism", "down-regulation of C6H6O4 anabolism"], "types": ["T044"], "canonical_name": "downregulation of C6H6O4 anabolism"}
{"concept_id": "C3546046", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of kojic acid biosynthetic process"}
{"concept_id": "C3546047", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of C6H6O4 synthesis"}
{"concept_id": "C3546048", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of C6H6O4 formation"}
{"concept_id": "C3546049", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of C6H6O4 biosynthetic process"}
{"concept_id": "C3546050", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of C6H6O4 biosynthesis"}
{"concept_id": "C3546051", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of C6H6O4 anabolism"}
{"concept_id": "C3546052", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of C6H6O4 synthesis"}
{"concept_id": "C3546053", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of C6H6O4 formation"}
{"concept_id": "C3546054", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of C6H6O4 biosynthetic process"}
{"concept_id": "C3546055", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of C6H6O4 biosynthesis"}
{"concept_id": "C3546056", "aliases": ["down-regulation of C6H6O4 synthesis"], "types": ["T044"], "canonical_name": "down regulation of C6H6O4 synthesis"}
{"concept_id": "C3546057", "aliases": ["down-regulation of C6H6O4 formation"], "types": ["T044"], "canonical_name": "down regulation of C6H6O4 formation"}
{"concept_id": "C3546058", "aliases": ["down-regulation of C6H6O4 biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of C6H6O4 biosynthetic process"}
{"concept_id": "C3546059", "aliases": ["down-regulation of C6H6O4 biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of C6H6O4 biosynthesis"}
{"concept_id": "C3546060", "aliases": [], "types": ["T044"], "canonical_name": "regulation of C6H6O4 synthesis"}
{"concept_id": "C3546061", "aliases": [], "types": ["T044"], "canonical_name": "regulation of C6H6O4 formation"}
{"concept_id": "C3546062", "aliases": [], "types": ["T044"], "canonical_name": "regulation of C6H6O4 biosynthetic process"}
{"concept_id": "C3546063", "aliases": [], "types": ["T044"], "canonical_name": "regulation of C6H6O4 biosynthesis"}
{"concept_id": "C3546064", "aliases": [], "types": ["T044"], "canonical_name": "regulation of C6H6O4 anabolism"}
{"concept_id": "C3546065", "aliases": ["upregulation of flavonol biosynthetic process", "up-regulation of flavonol biosynthetic process", "activation of flavonol biosynthetic process", "up regulation of flavonol biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of flavonol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of flavonol biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3546066", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of flavonol biosynthetic process"}
{"concept_id": "C3546067", "aliases": ["activation of asperthecin biosynthesis", "upregulation of asperthecin biosynthetic process", "up regulation of asperthecin biosynthetic process", "positive regulation of asperthecin biosynthesis", "upregulation of asperthecin formation", "positive regulation of asperthecin formation", "activation of asperthecin biosynthetic process", "positive regulation of asperthecin synthesis", "up-regulation of asperthecin biosynthesis", "activation of asperthecin formation", "upregulation of asperthecin biosynthesis", "up-regulation of asperthecin formation", "up-regulation of asperthecin synthesis", "up-regulation of asperthecin biosynthetic process", "up regulation of asperthecin formation", "up regulation of asperthecin biosynthesis", "up regulation of asperthecin synthesis", "activation of asperthecin synthesis", "upregulation of asperthecin synthesis"], "types": ["T044"], "canonical_name": "positive regulation of asperthecin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of asperthecin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3546068", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of asperthecin biosynthetic process"}
{"concept_id": "C3546069", "aliases": ["up-regulation of secondary metabolite biosynthetic process", "positive regulation of secondary metabolite biosynthesis", "activation of secondary metabolite biosynthetic process", "upregulation of secondary metabolite biosynthesis", "up-regulation of secondary metabolite biosynthesis", "up regulation of secondary metabolite biosynthetic process", "up regulation of secondary metabolite biosynthesis", "upregulation of secondary metabolite biosynthetic process", "activation of secondary metabolite biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of secondary metabolite biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3546070", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of secondary metabolite biosynthetic process"}
{"concept_id": "C3546082", "aliases": [], "types": ["T044"], "canonical_name": "activation of purine nucleotide biosynthetic process"}
{"concept_id": "C3546083", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of purine nucleotide biosynthetic process"}
{"concept_id": "C3546084", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA interference"}
{"concept_id": "C3546085", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of RNA interference"}
{"concept_id": "C3546086", "aliases": [], "types": ["T039"], "canonical_name": "activation of physiological defense response to insect"}
{"concept_id": "C3546087", "aliases": [], "types": ["T039"], "canonical_name": "activation of defense response to insect"}
{"concept_id": "C3546088", "aliases": [], "types": ["T040"], "canonical_name": "susceptibility to insect"}
{"concept_id": "C3546089", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of physiological defense response to insect"}
{"concept_id": "C3546090", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of defense response to insect"}
{"concept_id": "C3546091", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of cleavage and polyadenylylation specificity factor activity"}
{"concept_id": "C3546092", "aliases": ["up-regulation of cleavage and polyadenylylation specificity factor activity"], "types": ["T045"], "canonical_name": "up regulation of cleavage and polyadenylylation specificity factor activity"}
{"concept_id": "C3546093", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of cleavage and polyadenylylation specificity factor activity"}
{"concept_id": "C3546094", "aliases": [], "types": ["T045"], "canonical_name": "activation of mRNA polyadenylylation"}
{"concept_id": "C3546095", "aliases": [], "types": ["T045"], "canonical_name": "activation of mRNA polyadenylation"}
{"concept_id": "C3546096", "aliases": [], "types": ["T045"], "canonical_name": "activation of cleavage and polyadenylylation specificity factor activity"}
{"concept_id": "C3546097", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of cleavage and polyadenylylation specificity factor activity"}
{"concept_id": "C3546098", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mRNA polyadenylylation"}
{"concept_id": "C3546099", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mRNA polyadenylation"}
{"concept_id": "C3546100", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of cleavage and polyadenylylation specificity factor activity"}
{"concept_id": "C3546101", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of cleavage and polyadenylylation specificity factor activity"}
{"concept_id": "C3546102", "aliases": ["down-regulation of cleavage and polyadenylylation specificity factor activity"], "types": ["T045"], "canonical_name": "down regulation of cleavage and polyadenylylation specificity factor activity"}
{"concept_id": "C3546103", "aliases": [], "types": ["T045"], "canonical_name": "regulation of cleavage and polyadenylylation specificity factor activity"}
{"concept_id": "C3546104", "aliases": [], "types": ["T044"], "canonical_name": "activation of pentasaccharide transport"}
{"concept_id": "C3546105", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pentasaccharide transport"}
{"concept_id": "C3546106", "aliases": [], "types": ["T044"], "canonical_name": "activation of nigerotriose transport"}
{"concept_id": "C3546107", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nigerotriose transport"}
{"concept_id": "C3546108", "aliases": [], "types": ["T044"], "canonical_name": "activation of methanofuran metabolic process"}
{"concept_id": "C3546109", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methanofuran metabolic process"}
{"concept_id": "C3546110", "aliases": [], "types": ["T044"], "canonical_name": "activation of methanofuran biosynthetic process"}
{"concept_id": "C3546111", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methanofuran biosynthetic process"}
{"concept_id": "C3546112", "aliases": [], "types": ["T044"], "canonical_name": "activation of methane biosynthetic process from methylamine"}
{"concept_id": "C3546113", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methane biosynthetic process from methylamine"}
{"concept_id": "C3546114", "aliases": [], "types": ["T044"], "canonical_name": "activation of methane biosynthetic process from methanethiol"}
{"concept_id": "C3546115", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methane biosynthetic process from methanethiol"}
{"concept_id": "C3546116", "aliases": [], "types": ["T044"], "canonical_name": "activation of methane biosynthetic process from dimethyl sulfide"}
{"concept_id": "C3546117", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methane biosynthetic process from dimethyl sulfide"}
{"concept_id": "C3546118", "aliases": [], "types": ["T040"], "canonical_name": "activation of methane biosynthetic process from formic acid"}
{"concept_id": "C3546119", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methane biosynthetic process from formic acid"}
{"concept_id": "C3546120", "aliases": [], "types": ["T043"], "canonical_name": "activation of methane biosynthetic process from carbon monoxide"}
{"concept_id": "C3546121", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methane biosynthetic process from carbon monoxide"}
{"concept_id": "C3546122", "aliases": [], "types": ["T043"], "canonical_name": "activation of methane biosynthetic process from 3-(methylthio)propionic acid"}
{"concept_id": "C3546123", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methane biosynthetic process from 3-(methylthio)propionic acid"}
{"concept_id": "C3546124", "aliases": [], "types": ["T044"], "canonical_name": "activation of methane biosynthetic process from trimethylamine"}
{"concept_id": "C3546125", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methane biosynthetic process from trimethylamine"}
{"concept_id": "C3546126", "aliases": [], "types": ["T044"], "canonical_name": "activation of mannotriose transport"}
{"concept_id": "C3546127", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mannotriose transport"}
{"concept_id": "C3546128", "aliases": [], "types": ["T044"], "canonical_name": "activation of maltotriulose transport"}
{"concept_id": "C3546129", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maltotriulose transport"}
{"concept_id": "C3546130", "aliases": [], "types": ["T044"], "canonical_name": "activation of maltotetraose transport"}
{"concept_id": "C3546131", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maltotetraose transport"}
{"concept_id": "C3546132", "aliases": [], "types": ["T044"], "canonical_name": "activation of methane biosynthetic process from dimethylamine"}
{"concept_id": "C3546133", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methane biosynthetic process from dimethylamine"}
{"concept_id": "C3546134", "aliases": [], "types": ["T044"], "canonical_name": "activation of maltopentaose transport"}
{"concept_id": "C3546135", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maltopentaose transport"}
{"concept_id": "C3546136", "aliases": [], "types": ["T044"], "canonical_name": "activation of maltohexaose transport"}
{"concept_id": "C3546137", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maltohexaose transport"}
{"concept_id": "C3546138", "aliases": [], "types": ["T044"], "canonical_name": "activation of maltoheptaose metabolism"}
{"concept_id": "C3546139", "aliases": [], "types": ["T044"], "canonical_name": "activation of maltoheptaose metabolic process"}
{"concept_id": "C3546140", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maltoheptaose metabolism"}
{"concept_id": "C3546141", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maltoheptaose metabolic process"}
{"concept_id": "C3546142", "aliases": [], "types": ["T044"], "canonical_name": "activation of maltoheptaose transport"}
{"concept_id": "C3546143", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maltoheptaose transport"}
{"concept_id": "C3546144", "aliases": [], "types": ["T044"], "canonical_name": "activation of laminaritriose transport"}
{"concept_id": "C3546145", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of laminaritriose transport"}
{"concept_id": "C3546148", "aliases": [], "types": ["T044"], "canonical_name": "activation of hexasaccharide transport"}
{"concept_id": "C3546149", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hexasaccharide transport"}
{"concept_id": "C3546150", "aliases": [], "types": ["T044"], "canonical_name": "activation of heptasaccharide transport"}
{"concept_id": "C3546151", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of heptasaccharide transport"}
{"concept_id": "C3546152", "aliases": [], "types": ["T044"], "canonical_name": "activation of galactotriose transport"}
{"concept_id": "C3546153", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of galactotriose transport"}
{"concept_id": "C3546154", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3546155", "aliases": ["up-regulation of coenzyme F420-dependent nitroreductase activity"], "types": ["T044"], "canonical_name": "up regulation of coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3546156", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3546157", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3546158", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme F420-dependent nitroimidazole reduction"}
{"concept_id": "C3546159", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme F420-dependent nitroimidazole catabolism"}
{"concept_id": "C3546160", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme F420-dependent nitroimidazole breakdown"}
{"concept_id": "C3546161", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process"}
{"concept_id": "C3546162", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3546163", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3546164", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme F420-dependent nitroimidazole reduction"}
{"concept_id": "C3546165", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme F420-dependent nitroimidazole catabolism"}
{"concept_id": "C3546166", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme F420-dependent nitroimidazole breakdown"}
{"concept_id": "C3546167", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme F420-dependent bicyclic nitroimidazole catabolic process"}
{"concept_id": "C3546168", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3546169", "aliases": ["down-regulation of coenzyme F420-dependent nitroreductase activity"], "types": ["T044"], "canonical_name": "down regulation of coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3546170", "aliases": [], "types": ["T044"], "canonical_name": "regulation of coenzyme F420-dependent nitroreductase activity"}
{"concept_id": "C3546171", "aliases": [], "types": ["T044"], "canonical_name": "activation of cellotriose transport"}
{"concept_id": "C3546172", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellotriose transport"}
{"concept_id": "C3546173", "aliases": [], "types": ["T044"], "canonical_name": "activation of cellobiose catabolism"}
{"concept_id": "C3546174", "aliases": [], "types": ["T044"], "canonical_name": "activation of cellobiose catabolic process"}
{"concept_id": "C3546175", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cellobiose catabolism"}
{"concept_id": "C3546176", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cellobiose catabolic process"}
{"concept_id": "C3546177", "aliases": [], "types": ["T044"], "canonical_name": "activation of CD4-positive, alpha beta T cell costimulation"}
{"concept_id": "C3546178", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of CD4-positive, alpha beta T cell costimulation"}
{"concept_id": "C3546179", "aliases": [], "types": ["T039"], "canonical_name": "activation of proteinase activated receptor activity"}
{"concept_id": "C3546180", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of proteinase activated receptor activity"}
{"concept_id": "C3546181", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphatidase C"}
{"concept_id": "C3546182", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lipophosphodiesterase C"}
{"concept_id": "C3546183", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lecithinase C activity"}
{"concept_id": "C3546184", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phospholipase C activity"}
{"concept_id": "C3546185", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidase C"}
{"concept_id": "C3546186", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lipophosphodiesterase C"}
{"concept_id": "C3546187", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lecithinase C activity"}
{"concept_id": "C3546188", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of phosphatidase C"}
{"concept_id": "C3546189", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of lipophosphodiesterase C"}
{"concept_id": "C3546190", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of lecithinase C activity"}
{"concept_id": "C3546191", "aliases": ["down-regulation of phosphatidase C"], "types": ["T044"], "canonical_name": "down regulation of phosphatidase C"}
{"concept_id": "C3546192", "aliases": ["down-regulation of lipophosphodiesterase C"], "types": ["T044"], "canonical_name": "down regulation of lipophosphodiesterase C"}
{"concept_id": "C3546193", "aliases": ["down-regulation of lecithinase C activity"], "types": ["T044"], "canonical_name": "down regulation of lecithinase C activity"}
{"concept_id": "C3546194", "aliases": [], "types": ["T040"], "canonical_name": "regulation of phosphatidase C"}
{"concept_id": "C3546195", "aliases": [], "types": ["T040"], "canonical_name": "regulation of lipophosphodiesterase C"}
{"concept_id": "C3546196", "aliases": [], "types": ["T040"], "canonical_name": "regulation of lecithinase C activity"}
{"concept_id": "C3546197", "aliases": ["up-regulation of LTP", "up regulation of LTP"], "types": ["T044"], "canonical_name": "upregulation of LTP"}
{"concept_id": "C3546198", "aliases": ["up-regulation of long-term potentiation", "up regulation of long-term potentiation"], "types": ["T044"], "canonical_name": "upregulation of long-term potentiation"}
{"concept_id": "C3546199", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of LTP"}
{"concept_id": "C3546200", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of long-term potentiation"}
{"concept_id": "C3546201", "aliases": [], "types": ["T039"], "canonical_name": "activation of LTP"}
{"concept_id": "C3546202", "aliases": [], "types": ["T044"], "canonical_name": "activation of long-term synaptic potentiation"}
{"concept_id": "C3546203", "aliases": [], "types": ["T044"], "canonical_name": "activation of long-term potentiation"}
{"concept_id": "C3546204", "aliases": ["negative regulation of LTP"], "types": ["T038"], "canonical_name": "negative regulation of long-term potentiation"}
{"concept_id": "C3546205", "aliases": ["inhibition of LTP"], "types": ["T038"], "canonical_name": "inhibition of long-term potentiation"}
{"concept_id": "C3546206", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of long-term synaptic potentiation"}
{"concept_id": "C3546207", "aliases": ["down regulation of LTP", "down regulation of long-term potentiation", "down-regulation of LTP", "down-regulation of long-term potentiation", "downregulation of LTP"], "types": ["T044"], "canonical_name": "downregulation of long-term potentiation"}
{"concept_id": "C3546208", "aliases": ["regulation of long-term potentiation", "regulation of LTP"], "types": ["T038"], "canonical_name": "regulation of long-term synaptic potentiation", "definition": "Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3546209", "aliases": ["autotransporter system complex location"], "types": ["T026"], "canonical_name": "autotransporter system complex"}
{"concept_id": "C3546210", "aliases": [], "types": ["T026"], "canonical_name": "bacteriophage tail shaft"}
{"concept_id": "C3546211", "aliases": [], "types": ["T026"], "canonical_name": "bacteriophage tail sheath"}
{"concept_id": "C3546212", "aliases": [], "types": ["T026"], "canonical_name": "bacteriophage tail tube"}
{"concept_id": "C3546213", "aliases": [], "types": ["T026"], "canonical_name": "bacteriophage baseplate"}
{"concept_id": "C3546214", "aliases": [], "types": ["T026"], "canonical_name": "bacteriophage tail fiber"}
{"concept_id": "C3546215", "aliases": [], "types": ["T026"], "canonical_name": "bacteriophage tail tip"}
{"concept_id": "C3546216", "aliases": [], "types": ["T026"], "canonical_name": "head/capsid fiber"}
{"concept_id": "C3546217", "aliases": [], "types": ["T026"], "canonical_name": "decoration protein"}
{"concept_id": "C3546220", "aliases": [], "types": ["T026"], "canonical_name": "minor head protein"}
{"concept_id": "C3546221", "aliases": [], "types": ["T026"], "canonical_name": "major head protein"}
{"concept_id": "C3546222", "aliases": [], "types": ["T026"], "canonical_name": "viral tail"}
{"concept_id": "C3546223", "aliases": [], "types": ["T026"], "canonical_name": "bacteriophage tail"}
{"concept_id": "C3546224", "aliases": [], "types": ["T043"], "canonical_name": "phage headful packaging"}
{"concept_id": "C3546225", "aliases": [], "types": ["T039"], "canonical_name": "phage head tail joining"}
{"concept_id": "C3546226", "aliases": [], "types": ["T039"], "canonical_name": "bacteriophage tail assembly"}
{"concept_id": "C3546227", "aliases": [], "types": ["T038"], "canonical_name": "phage irreversible adsorption"}
{"concept_id": "C3546228", "aliases": [], "types": ["T038"], "canonical_name": "phage reversible adsorption"}
{"concept_id": "C3546229", "aliases": [], "types": ["T043"], "canonical_name": "programmed cell death in response to oxidative stress"}
{"concept_id": "C3546230", "aliases": [], "types": ["T043"], "canonical_name": "PCD in response to oxidative stress"}
{"concept_id": "C3546232", "aliases": [], "types": ["T026"], "canonical_name": "mesaxon of Schwann cell"}
{"concept_id": "C3546233", "aliases": [], "types": ["T026"], "canonical_name": "vellous process"}
{"concept_id": "C3546234", "aliases": [], "types": ["T026"], "canonical_name": "peripheral astrocyte process"}
{"concept_id": "C3546235", "aliases": [], "types": ["T026"], "canonical_name": "dense material"}
{"concept_id": "C3546236", "aliases": ["MVB-tubule complex location"], "types": ["T026"], "canonical_name": "MVB-tubule complex"}
{"concept_id": "C3546237", "aliases": [], "types": ["T043"], "canonical_name": "copper ion transport into forespores"}
{"concept_id": "C3546238", "aliases": [], "types": ["T026"], "canonical_name": "coated tip"}
{"concept_id": "C3546239", "aliases": [], "types": ["T020"], "canonical_name": "star-shaped neurofibrillary tangle"}
{"concept_id": "C3546240", "aliases": [], "types": ["T026"], "canonical_name": "flame-shaped neurofibrillary tangle"}
{"concept_id": "C3546241", "aliases": [], "types": ["T026"], "canonical_name": "brainstem Lewy body"}
{"concept_id": "C3546242", "aliases": [], "types": ["T026"], "canonical_name": "pale body"}
{"concept_id": "C3546244", "aliases": [], "types": ["T026"], "canonical_name": "glial projection"}
{"concept_id": "C3546245", "aliases": [], "types": ["T026"], "canonical_name": "glial process"}
{"concept_id": "C3546246", "aliases": [], "types": ["T043"], "canonical_name": "dorsal interneuron rostral axon projection"}
{"concept_id": "C3546247", "aliases": [], "types": ["T043"], "canonical_name": "dorsal interneuron caudal axon projection"}
{"concept_id": "C3546248", "aliases": [], "types": ["T040"], "canonical_name": "response to broncholytic agent"}
{"concept_id": "C3546249", "aliases": ["cytosolic iron-sulfur protein assembly complex location"], "types": ["T026"], "canonical_name": "cytosolic iron-sulfur protein assembly complex"}
{"concept_id": "C3546250", "aliases": [], "types": ["T044"], "canonical_name": "prevention of caspase activity"}
{"concept_id": "C3546251", "aliases": [], "types": ["T045"], "canonical_name": "cap2 mRNA capping"}
{"concept_id": "C3546252", "aliases": [], "types": ["T045"], "canonical_name": "cap1 mRNA capping"}
{"concept_id": "C3546253", "aliases": [], "types": ["T043"], "canonical_name": "potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C3546254", "aliases": [], "types": ["T043"], "canonical_name": "regulated necrosis"}
{"concept_id": "C3546256", "aliases": [], "types": ["T044"], "canonical_name": "activation of effector caspase activity"}
{"concept_id": "C3546257", "aliases": [], "types": ["T044"], "canonical_name": "activation of initiator caspase activity"}
{"concept_id": "C3546258", "aliases": ["L-ascorbic acid biosynthesis via UDP-alpha-D-glucuronate"], "types": ["T044"], "canonical_name": "L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate", "definition": "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate. [BioCyc:PWY3DJ-35471, GOC:yaf, PMID:11153268, UniPathway:UPA00991]"}
{"concept_id": "C3546259", "aliases": ["Smirnoff-Wheeler's pathway", "L-ascorbic acid biosynthesis via GDP-alpha-D-mannose"], "types": ["T044"], "canonical_name": "L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose", "definition": "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose. [GOC:yaf, PMID:11153268]"}
{"concept_id": "C3546261", "aliases": ["axillary bud meristem initiation"], "types": ["T042"], "canonical_name": "axillary shoot meristem initiation", "definition": "A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf. [GOC:tb]"}
{"concept_id": "C3546262", "aliases": [], "types": ["T044"], "canonical_name": "pimelyl-[acyl-carrier protein] methyl ester hydrolase activity"}
{"concept_id": "C3546263", "aliases": [], "types": ["T044"], "canonical_name": "tryptophan N-monooxygenase activity"}
{"concept_id": "C3546266", "aliases": [], "types": ["T044"], "canonical_name": "9,15,9'-tricis-zeta-carotene cis-trans-isomerase"}
{"concept_id": "C3546267", "aliases": ["vacuolar ornithine import"], "types": ["T043"], "canonical_name": "ornithine transmembrane import into vacuole", "definition": "The directed movement of ornithine into the vacuole across the vacuolar membrane. [GOC:tb]"}
{"concept_id": "C3546268", "aliases": ["vacuolar glutamate import"], "types": ["T043"], "canonical_name": "glutamate transmembrane import into vacuole", "definition": "The directed movement of glutamate into the vacuole across the vacuolar membrane. [GOC:tb]"}
{"concept_id": "C3546269", "aliases": ["STRIPAK signalling complex location"], "types": ["T026"], "canonical_name": "STRIPAK signalling complex"}
{"concept_id": "C3546270", "aliases": ["FAR complex location"], "types": ["T026"], "canonical_name": "FAR complex"}
{"concept_id": "C3546271", "aliases": ["HWM phytochelatin complex formation"], "types": ["T044"], "canonical_name": "high molecular weight phytochelatin complex formation"}
{"concept_id": "C3546272", "aliases": ["LWM phytochelatin complex formation"], "types": ["T044"], "canonical_name": "low molecular weight phytochelatin complex formation"}
{"concept_id": "C3546273", "aliases": [], "types": ["T043"], "canonical_name": "platelet disaggregation"}
{"concept_id": "C3546274", "aliases": [], "types": ["T044"], "canonical_name": "Gi-coupled G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate"}
{"concept_id": "C3546275", "aliases": [], "types": ["T044"], "canonical_name": "AC-inhibiting muscarinic receptor signaling pathway involved in negative regulation of heart rate"}
{"concept_id": "C3546276", "aliases": [], "types": ["T044"], "canonical_name": "endothelin signaling pathway"}
{"concept_id": "C3546277", "aliases": [], "types": ["T043"], "canonical_name": "muscarinic receptor signaling pathway involved in ion channel activation"}
{"concept_id": "C3546278", "aliases": [], "types": ["T043"], "canonical_name": "Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate"}
{"concept_id": "C3546279", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscarinic receptor signaling via Gbeta/gamma"}
{"concept_id": "C3546280", "aliases": [], "types": ["T038"], "canonical_name": "adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation"}
{"concept_id": "C3546281", "aliases": [], "types": ["T044"], "canonical_name": "muscarinic receptor signaling pathway involved in heart process"}
{"concept_id": "C3546282", "aliases": [], "types": ["T044"], "canonical_name": "M2 receptor signaling pathway involved in heart process"}
{"concept_id": "C3546284", "aliases": [], "types": ["T043"], "canonical_name": "sinus node cardiomyocyte to atrial cardiomyocyte communication"}
{"concept_id": "C3546285", "aliases": [], "types": ["T043"], "canonical_name": "membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential"}
{"concept_id": "C3546286", "aliases": [], "types": ["T044"], "canonical_name": "adrenergic receptor-induced cardiac relaxation"}
{"concept_id": "C3546287", "aliases": [], "types": ["T044"], "canonical_name": "adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC"}
{"concept_id": "C3546288", "aliases": [], "types": ["T044"], "canonical_name": "If activation by beta-adrenergic receptor signaling pathway"}
{"concept_id": "C3546289", "aliases": [], "types": ["T044"], "canonical_name": "beta adrenergic receptor signaling pathway involved in positive regulation of heart rate"}
{"concept_id": "C3546290", "aliases": [], "types": ["T044"], "canonical_name": "adenylate cyclase-activating cardiac adrenergic receptor signaling pathway"}
{"concept_id": "C3546291", "aliases": [], "types": ["T044"], "canonical_name": "activation of funny current by beta-adrenergic receptor signaling pathway"}
{"concept_id": "C3546292", "aliases": [], "types": ["T044"], "canonical_name": "beta-adrenergic receptor signalling pathway involved in heart process"}
{"concept_id": "C3546293", "aliases": [], "types": ["T043"], "canonical_name": "sinus node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication"}
{"concept_id": "C3546294", "aliases": [], "types": ["T043"], "canonical_name": "sinus node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling"}
{"concept_id": "C3546295", "aliases": [], "types": ["T043"], "canonical_name": "sinus node cardiomyocyte to atrial cardiomyocyte signalling"}
{"concept_id": "C3546296", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sinus node cardiac muscle cell action potential"}
{"concept_id": "C3546298", "aliases": [], "types": ["T038"], "canonical_name": "establishment as a plasmid prophage"}
{"concept_id": "C3546299", "aliases": [], "types": ["T045"], "canonical_name": "kinetochore localization at spindle pole body"}
{"concept_id": "C3546300", "aliases": ["kinetochore clustering at the old mitotic spindle pole body"], "types": ["T043"], "canonical_name": "centromere clustering at the mitotic interphase nuclear envelope", "definition": "The process in which chromatin, or kinetochores are anchored to the nuclear envelope. This process involves the microtubule cytoskeleton, and nuclear tethering factors and is responsible for the Rabl-like configuration of chromosomes in the interphase nuclei. [GOC:mah, GOC:vw, PMID:21965289, PMID:23166349]"}
{"concept_id": "C3546301", "aliases": [], "types": ["T045"], "canonical_name": "kinetochore clustering at spindle pole body"}
{"concept_id": "C3546302", "aliases": [], "types": ["T045"], "canonical_name": "kinetochore clustering at SPB"}
{"concept_id": "C3546303", "aliases": [], "types": ["T045"], "canonical_name": "centromere-SPB clustering"}
{"concept_id": "C3546304", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to thialysine"}
{"concept_id": "C3546305", "aliases": [], "types": ["T043"], "canonical_name": "response to mitotic G2/M transition decatenation checkpoint signaling"}
{"concept_id": "C3546306", "aliases": [], "types": ["T043"], "canonical_name": "response to mitotic cell cycle G1/S checkpoint signaling"}
{"concept_id": "C3546307", "aliases": [], "types": ["T043"], "canonical_name": "response to G2/M transition checkpoint signaling"}
{"concept_id": "C3546308", "aliases": [], "types": ["T043"], "canonical_name": "response to G1/S transition checkpoint signaling"}
{"concept_id": "C3546309", "aliases": ["activation-induced cell death"], "types": ["T043"], "canonical_name": "AICD"}
{"concept_id": "C3546310", "aliases": ["inhibition of adenylate cyclase activity by adrenergic receptor signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway"}
{"concept_id": "C3546311", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to oxygen"}
{"concept_id": "C3546312", "aliases": ["SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex location"], "types": ["T026"], "canonical_name": "SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex"}
{"concept_id": "C3546313", "aliases": ["programmed cell death by necrosis", "programmed necrotic cell death"], "types": ["T043"], "canonical_name": "programmed necrotic cell death", "definition": "A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. [GOC:mtg_apoptosis, PMID:21760595]"}
{"concept_id": "C3546314", "aliases": ["SPA synthase"], "types": ["T044"], "canonical_name": "sulfinylpropanyl adenylate synthase", "definition": "Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H(+) + phosphate. [GOC:dph, PMID:8346915]"}
{"concept_id": "C3546315", "aliases": ["ICC differentiation"], "types": ["T043"], "canonical_name": "interstitial cell of Cajal differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. [GOC:dph]"}
{"concept_id": "C3546316", "aliases": ["ovary morphogenesis"], "types": ["T042"], "canonical_name": "female gonad morphogenesis", "definition": "The process in which a female gonad is generated and organized. [GOC:BHF, GOC:dph]"}
{"concept_id": "C3546317", "aliases": [], "types": ["T043"], "canonical_name": "sinus node cell development"}
{"concept_id": "C3546318", "aliases": [], "types": ["T043"], "canonical_name": "sinus node cell commitment"}
{"concept_id": "C3546319", "aliases": [], "types": ["T043"], "canonical_name": "sinus node cell differentiation"}
{"concept_id": "C3546320", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in development"}
{"concept_id": "C3546321", "aliases": [], "types": ["T043"], "canonical_name": "activation of necroptosis in response to extracellular signals"}
{"concept_id": "C3546322", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of dopamine uptake involved in synaptic transmission"}
{"concept_id": "C3546323", "aliases": [], "types": ["T043"], "canonical_name": "activation of dopamine uptake involved in synaptic transmission"}
{"concept_id": "C3546324", "aliases": [], "types": ["T026"], "canonical_name": "pre-synaptic dense body"}
{"concept_id": "C3546325", "aliases": [], "types": ["T043"], "canonical_name": "axon branching"}
{"concept_id": "C3546326", "aliases": [], "types": ["T043"], "canonical_name": "sperm activation"}
{"concept_id": "C3546327", "aliases": [], "types": ["T044"], "canonical_name": "TrkC signaling pathway"}
{"concept_id": "C3546328", "aliases": [], "types": ["T044"], "canonical_name": "TrkB signaling pathway"}
{"concept_id": "C3546329", "aliases": [], "types": ["T044"], "canonical_name": "TrkA signaling pathway"}
{"concept_id": "C3546330", "aliases": [], "types": ["T044"], "canonical_name": "TAPBP binding"}
{"concept_id": "C3546331", "aliases": [], "types": ["T043"], "canonical_name": "viral escort protein"}
{"concept_id": "C3546332", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cilium assembly"}
{"concept_id": "C3546333", "aliases": [], "types": ["T043"], "canonical_name": "activation of cilium assembly"}
{"concept_id": "C3546334", "aliases": [], "types": ["T030"], "canonical_name": "mixed synapse"}
{"concept_id": "C3546335", "aliases": [], "types": ["T045"], "canonical_name": "exonucleolytic trimming to generate 3' end of miRNA"}
{"concept_id": "C3546336", "aliases": ["(Ost)2 complex location"], "types": ["T026"], "canonical_name": "(Ost)2 complex"}
{"concept_id": "C3546337", "aliases": [], "types": ["T045"], "canonical_name": "changes in DNA methylation"}
{"concept_id": "C3546338", "aliases": [], "types": ["T045"], "canonical_name": "viral genome delivery via icosahedral vertex"}
{"concept_id": "C3546339", "aliases": [], "types": ["T044"], "canonical_name": "MptA activity"}
{"concept_id": "C3546340", "aliases": [], "types": ["T026"], "canonical_name": "methyl-H4MPT"}
{"concept_id": "C3546341", "aliases": ["coenzyme M methyltransferase complex location"], "types": ["T026"], "canonical_name": "coenzyme M methyltransferase complex"}
{"concept_id": "C3546342", "aliases": ["CO dehydrogenase complex location"], "types": ["T026"], "canonical_name": "CO dehydrogenase complex"}
{"concept_id": "C3546343", "aliases": ["carbon-monoxide:(acceptor) oxidoreductase complex location"], "types": ["T026"], "canonical_name": "carbon-monoxide:(acceptor) oxidoreductase complex"}
{"concept_id": "C3546344", "aliases": [], "types": ["T038"], "canonical_name": "regulation of complement activation, alternative pathway in other organism"}
{"concept_id": "C3546345", "aliases": ["4Fe-4S cluster assembly", "[4Fe-4S] cluster biosynthetic process"], "types": ["T044"], "canonical_name": "[4Fe-4S] cluster assembly", "definition": "The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster. [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]"}
{"concept_id": "C3546346", "aliases": ["2Fe-2S cluster assembly", "[2Fe-2S] cluster biosynthetic process"], "types": ["T044"], "canonical_name": "[2Fe-2S] cluster assembly", "definition": "The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]"}
{"concept_id": "C3546347", "aliases": [], "types": ["T026"], "canonical_name": "terminal specialization"}
{"concept_id": "C3546348", "aliases": [], "types": ["T026"], "canonical_name": "paranodal loop"}
{"concept_id": "C3546349", "aliases": [], "types": ["T026"], "canonical_name": "oligodendrocyte paranodal termination"}
{"concept_id": "C3546350", "aliases": [], "types": ["T026"], "canonical_name": "oligodendrocyte compact myelin"}
{"concept_id": "C3546351", "aliases": [], "types": ["T026"], "canonical_name": "oligodendrocyte myelin sheath"}
{"concept_id": "C3546352", "aliases": [], "types": ["T026"], "canonical_name": "astrocyte sheath"}
{"concept_id": "C3546353", "aliases": [], "types": ["T043"], "canonical_name": "extracellular fibril organization and biogenesis"}
{"concept_id": "C3546354", "aliases": [], "types": ["T026"], "canonical_name": "thin dendritic spine"}
{"concept_id": "C3546355", "aliases": [], "types": ["T026"], "canonical_name": "stubby dendritic spine"}
{"concept_id": "C3546356", "aliases": [], "types": ["T026"], "canonical_name": "sessile dendritic spine"}
{"concept_id": "C3546357", "aliases": [], "types": ["T026"], "canonical_name": "mushroom dendritic spine"}
{"concept_id": "C3546358", "aliases": [], "types": ["T026"], "canonical_name": "branched dendritic spine"}
{"concept_id": "C3546359", "aliases": [], "types": ["T043"], "canonical_name": "pro-apoptosis"}
{"concept_id": "C3546360", "aliases": ["suppression by virus of host DNA-dependent transcription", "host transcription shutoff by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host transcription", "definition": "Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors. [UniProtKB-KW:KW-1191, VZ:1577]"}
{"concept_id": "C3546361", "aliases": [], "types": ["T043"], "canonical_name": "activation of host caspases by virus"}
{"concept_id": "C3546362", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of host caspases by virus"}
{"concept_id": "C3546363", "aliases": [], "types": ["T044"], "canonical_name": "modulation of host E3 ubiquitin ligases by virus"}
{"concept_id": "C3546364", "aliases": [], "types": ["T038"], "canonical_name": "modulation of host ubiquitin pathway by virus"}
{"concept_id": "C3546365", "aliases": [], "types": ["T040"], "canonical_name": "lysis inhibition"}
{"concept_id": "C3546366", "aliases": ["viral inhibition of host peptidoglycan biosynthesis"], "types": ["T043"], "canonical_name": "suppression by virus of host peptidoglycan biosynthetic process", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls. [GOC:bf, GOC:bm, GOC:jl]"}
{"concept_id": "C3546367", "aliases": [], "types": ["T040"], "canonical_name": "killing by phage of host cells"}
{"concept_id": "C3546368", "aliases": [], "types": ["T045"], "canonical_name": "viral RNA packaging activity"}
{"concept_id": "C3546369", "aliases": [], "types": ["T045"], "canonical_name": "viral DNA packaging motor activity"}
{"concept_id": "C3546370", "aliases": [], "types": ["T045"], "canonical_name": "viral DNA packaging activity"}
{"concept_id": "C3546371", "aliases": ["inhibition of activity of host translation initiation factor", "suppression by virus of host EIF-4E activity", "inactivation of eIF2 activity", "Inhibition of host translation factors by virus"], "types": ["T045"], "canonical_name": "suppression by virus of host translation initiation factor activity", "definition": "Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor. [GOC:bf, UniProtKB-KW:KW-1075]"}
{"concept_id": "C3546377", "aliases": ["inhibition of host complement cascade by virus", "inhibition of host complement factors by virus", "inhibition of host complement activation by virus"], "types": ["T044"], "canonical_name": "suppression by virus of host complement activation", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase. [PMID:21191012, PMID:7745740, UniProtKB-KW:KW-1087, VZ:811]"}
{"concept_id": "C3546381", "aliases": ["inhibition of host STAT2 by virus", "inhibition by virus of host STAT2 activity"], "types": ["T040"], "canonical_name": "suppression by virus of host STAT2 activity"}
{"concept_id": "C3546382", "aliases": ["inhibition by virus of host STAT1 activity", "inhibition of host STAT1 by virus"], "types": ["T040"], "canonical_name": "suppression by virus of host STAT1 activity"}
{"concept_id": "C3546383", "aliases": [], "types": ["T038"], "canonical_name": "inhibition by virus of host STAT activity"}
{"concept_id": "C3546387", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of host IFIH1/MDA5 by virus"}
{"concept_id": "C3546388", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of SREBP-mediated signaling pathway in absence of oxygen"}
{"concept_id": "C3546389", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of SREBP-mediated signaling pathway in presence of oxygen"}
{"concept_id": "C3546390", "aliases": [], "types": ["T043"], "canonical_name": "interleukin-17A signaling pathway"}
{"concept_id": "C3546391", "aliases": [], "types": ["T043"], "canonical_name": "interleukin-33 signaling pathway"}
{"concept_id": "C3546392", "aliases": ["SSTR signaling pathway", "SST receptor signaling pathway"], "types": ["T044"], "canonical_name": "somatostatin receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:jc, PMID:18006219, PMID:8769369]"}
{"concept_id": "C3546393", "aliases": ["angiotensin-mediated signaling pathway", "angiotensin II-mediated signaling pathway", "angiotensin receptor signaling pathway"], "types": ["T044"], "canonical_name": "angiotensin-activated signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869]"}
{"concept_id": "C3546394", "aliases": ["CSF3 signaling pathway", "G-CSF receptor signaling pathway", "granulocyte colony-stimulating factor signalling pathway", "G-CSF signaling pathway", "granulocyte colony-stimulating factor receptor signaling pathway"], "types": ["T043"], "canonical_name": "granulocyte colony-stimulating factor signaling pathway", "definition": "The series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R). [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3546395", "aliases": ["granulocyte-macrophage colony-stimulating factor signalling pathway", "granulocyte-macrophage colony-stimulating factor receptor signaling pathway", "CSF2 signaling pathway", "GM-CSF receptor signaling pathway", "GM-CSF signaling pathway"], "types": ["T043"], "canonical_name": "granulocyte-macrophage colony-stimulating factor signaling pathway", "definition": "The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors. [GOC:nhn, GOC:signaling, PMID:17027509]"}
{"concept_id": "C3546396", "aliases": ["CCL2/CCR4 signaling pathway"], "types": ["T043"], "canonical_name": "CCL2-activated CCR4 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3546397", "aliases": [], "types": ["T044"], "canonical_name": "SDF-1 receptor activity"}
{"concept_id": "C3546398", "aliases": [], "types": ["T043"], "canonical_name": "CXCL12-activated CXCR7 signaling pathway"}
{"concept_id": "C3546399", "aliases": [], "types": ["T044"], "canonical_name": "D-alanyl carrier protein"}
{"concept_id": "C3546400", "aliases": [], "types": ["T039"], "canonical_name": "cone phototransduction termination"}
{"concept_id": "C3546401", "aliases": ["fruiting body stalk morphogenesis"], "types": ["T038"], "canonical_name": "sorocarp stalk morphogenesis", "definition": "The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum. [DDANAT:0000068, GOC:pf, PMID:22902739]"}
{"concept_id": "C3546402", "aliases": [], "types": ["T038"], "canonical_name": "chitin-based cuticle sclerotization by protein cross-linking and cuticle tanning"}
{"concept_id": "C3546403", "aliases": [], "types": ["T044"], "canonical_name": "FasL signaling pathway"}
{"concept_id": "C3546404", "aliases": ["FAS ligand-Fas signaling pathway"], "types": ["T044"], "canonical_name": "Fas-FasL signaling pathway"}
{"concept_id": "C3546405", "aliases": ["PlGF-activated receptor activity", "PlGF receptor activity", "placental growth factor-activated receptor activity"], "types": ["T044"], "canonical_name": "placental growth factor receptor activity", "definition": "Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:uh, PMID:12871269, PMID:7929268, Wikipedia:Placental_growth_factor]"}
{"concept_id": "C3546406", "aliases": ["PP secretion"], "types": ["T043"], "canonical_name": "pancreatic polypeptide secretion", "definition": "The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas. [GOC:cjm, PMID:12730894, Wikipedia:Pancreatic_polypeptide]"}
{"concept_id": "C3546407", "aliases": [], "types": ["T043"], "canonical_name": "pancreatic ghrelin secretion"}
{"concept_id": "C3546408", "aliases": [], "types": ["T044"], "canonical_name": "p110 binding"}
{"concept_id": "C3546409", "aliases": [], "types": ["T044"], "canonical_name": "p85 binding"}
{"concept_id": "C3546410", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent DNA annealing activity"}
{"concept_id": "C3546412", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to M line"}
{"concept_id": "C3546413", "aliases": [], "types": ["T043"], "canonical_name": "B cell receptor uptake of antigen"}
{"concept_id": "C3546414", "aliases": [], "types": ["T045"], "canonical_name": "single-stranded DNA bubble rewinding"}
{"concept_id": "C3546415", "aliases": [], "types": ["T045"], "canonical_name": "RPA-dependent DNA rewinding"}
{"concept_id": "C3546417", "aliases": ["hypermethylation of snRNA cap"], "types": ["T045"], "canonical_name": "hypermethylation of snoRNA cap"}
{"concept_id": "C3546418", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to menadione stress"}
{"concept_id": "C3546419", "aliases": [], "types": ["T043"], "canonical_name": "vacuolar cadmium import"}
{"concept_id": "C3546420", "aliases": [], "types": ["T044"], "canonical_name": "acyl-glucuronide deglucuronidation activity"}
{"concept_id": "C3546423", "aliases": ["dTMP biosynthesis via salvage pathway", "deoxythymidine monophosphate biosynthesis via salvage pathway"], "types": ["T044"], "canonical_name": "dTMP salvage", "definition": "Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis. [GOC:yaf, UniPathway:UPA00578]"}
{"concept_id": "C3546424", "aliases": [], "types": ["T026"], "canonical_name": "myopodia"}
{"concept_id": "C3546425", "aliases": [], "types": ["T044"], "canonical_name": "abietadiene hydroxylase"}
{"concept_id": "C3546426", "aliases": [], "types": ["T044"], "canonical_name": "abietadienal dehydrogenase"}
{"concept_id": "C3546427", "aliases": [], "types": ["T040"], "canonical_name": "yeast to hyphal transition"}
{"concept_id": "C3546428", "aliases": [], "types": ["T043"], "canonical_name": "flagellar motility"}
{"concept_id": "C3546429", "aliases": [], "types": ["T045"], "canonical_name": "CENP-A loading"}
{"concept_id": "C3546430", "aliases": [], "types": ["T045"], "canonical_name": "CENP-A deposition"}
{"concept_id": "C3546431", "aliases": [], "types": ["T044"], "canonical_name": "ribosome recycling"}
{"concept_id": "C3546432", "aliases": ["peripheral endoplasmic reticulum"], "types": ["T026"], "canonical_name": "peripheral ER"}
{"concept_id": "C3546433", "aliases": ["negative regulation of DNA replication initiation"], "types": ["T045"], "canonical_name": "negative regulation of DNA replication initiation"}
{"concept_id": "C3546434", "aliases": [], "types": ["T026"], "canonical_name": "mitochondrial aggregate"}
{"concept_id": "C3546435", "aliases": ["inhibition of adenylate cyclase activity by opioid receptor signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of adenylate cyclase activity by opioid receptor signaling pathway"}
{"concept_id": "C3546436", "aliases": ["AMPK complex location"], "types": ["T026"], "canonical_name": "AMPK complex"}
{"concept_id": "C3546437", "aliases": [], "types": ["T043"], "canonical_name": "cytoskeleton polarization"}
{"concept_id": "C3546439", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA replication initiation"}
{"concept_id": "C3546440", "aliases": [], "types": ["T038"], "canonical_name": "spore dormancy process"}
{"concept_id": "C3546441", "aliases": ["glutamine degradation to fumarate, using glutaminase", "glutamine breakdown to fumarate, using glutaminase"], "types": ["T044"], "canonical_name": "glutamine catabolic process to fumarate, using glutaminase", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2). [GOC:bf, GOC:jl]"}
{"concept_id": "C3546442", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor"}
{"concept_id": "C3546443", "aliases": [], "types": ["T026"], "canonical_name": "neuronal cytoplasmic inclusion"}
{"concept_id": "C3546444", "aliases": [], "types": ["T043"], "canonical_name": "rod response recovery"}
{"concept_id": "C3546445", "aliases": ["ASIC activity", "acid-sensing ion channel activity"], "types": ["T044"], "canonical_name": "acid-sensing ion channel activity", "definition": "Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex. [GOC:jl]"}
{"concept_id": "C3546446", "aliases": [], "types": ["T043"], "definition": "Genetically encoded mechanisms in multicellular and unicellular eukaryotes that function to eliminate cells that are superfluous either during development, or to maintain tissue and organism homeostasis; and cells that are irreversibly damaged, abnormal, and/or potentially harmful.", "canonical_name": "regulated cell death"}
{"concept_id": "C3546447", "aliases": [], "types": ["T044"], "canonical_name": "arabinoxylan metabolic process"}
{"concept_id": "C3546448", "aliases": [], "types": ["T038"], "canonical_name": "shoot branching"}
{"concept_id": "C3546449", "aliases": [], "types": ["T038"], "canonical_name": "fruit senescence"}
{"concept_id": "C3546450", "aliases": [], "types": ["T044"], "canonical_name": "apoptotic signaling pathway in response to hormone"}
{"concept_id": "C3546451", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic signaling pathway in response to granzyme"}
{"concept_id": "C3546452", "aliases": [], "types": ["T045"], "canonical_name": "stem-loop-containing histone mRNA 3'-end processing"}
{"concept_id": "C3546453", "aliases": [], "types": ["T043"], "canonical_name": "accidental cell death"}
{"concept_id": "C3546454", "aliases": [], "types": ["T026"], "canonical_name": "docked vesicle"}
{"concept_id": "C3546455", "aliases": ["inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway"}
{"concept_id": "C3546456", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway"}
{"concept_id": "C3546457", "aliases": ["activation of adenylate cyclase activity by dopamine receptor signalling pathway"], "types": ["T044"], "canonical_name": "activation of adenylate cyclase activity by dopamine receptor signaling pathway"}
{"concept_id": "C3546458", "aliases": ["activation of adenylate cyclase activity involved in G-protein signaling"], "types": ["T044"], "canonical_name": "activation of adenylate cyclase activity by G-protein signaling pathway"}
{"concept_id": "C3546459", "aliases": [], "types": ["T043"], "canonical_name": "sister chromatid alignment"}
{"concept_id": "C3546460", "aliases": [], "types": ["T043"], "canonical_name": "copper-induced protein export from nucleus"}
{"concept_id": "C3546461", "aliases": [], "types": ["T045"], "canonical_name": "chromatinolysis"}
{"concept_id": "C3546462", "aliases": [], "types": ["T026"], "canonical_name": "neurotubule"}
{"concept_id": "C3546463", "aliases": [], "types": ["T026"], "canonical_name": "peroxisomal"}
{"concept_id": "C3546465", "aliases": ["hyperpolarization-activated cyclic nucleotide-gated channel activity"], "types": ["T044"], "canonical_name": "HCN channel activity"}
{"concept_id": "C3546466", "aliases": [], "types": ["T044"], "canonical_name": "endocannabinoid receptor activity"}
{"concept_id": "C3546467", "aliases": [], "types": ["T044"], "canonical_name": "retinal reductase activity"}
{"concept_id": "C3546468", "aliases": [], "types": ["T044"], "canonical_name": "AMPK activity"}
{"concept_id": "C3546469", "aliases": [], "types": ["T044"], "canonical_name": "alpha-methylglucosidase activity"}
{"concept_id": "C3546470", "aliases": [], "types": ["T044"], "canonical_name": "prophenoloxidase activity"}
{"concept_id": "C3546471", "aliases": [], "types": ["T043"], "canonical_name": "ciliary motility"}
{"concept_id": "C3546472", "aliases": [], "types": ["T042"], "canonical_name": "sinus node development"}
{"concept_id": "C3546473", "aliases": ["TNF receptor superfamily complex", "tumor necrosis factor receptor superfamily complex location", "TNF receptor superfamily complex location"], "types": ["T026"], "canonical_name": "tumor necrosis factor receptor superfamily complex", "definition": "A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily. [GOC:krc]"}
{"concept_id": "C3546474", "aliases": ["CycK/Cdk13 complex location"], "types": ["T026"], "canonical_name": "CycK/Cdk13 complex"}
{"concept_id": "C3546475", "aliases": ["CycK/Cdk12 complex location"], "types": ["T026"], "canonical_name": "CycK/Cdk12 complex"}
{"concept_id": "C3546476", "aliases": [], "types": ["T045"], "canonical_name": "tRNA m2-guanine biosynthesis"}
{"concept_id": "C3546477", "aliases": [], "types": ["T045"], "canonical_name": "tRNA m1-guanine biosynthesis"}
{"concept_id": "C3546478", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid hydroxylation"}
{"concept_id": "C3546479", "aliases": ["sperm protein complex I location"], "types": ["T026"], "canonical_name": "sperm protein complex I"}
{"concept_id": "C3546482", "aliases": [], "types": ["T045"], "canonical_name": "maturation of 18S rRNA"}
{"concept_id": "C3546486", "aliases": [], "types": ["T043"], "canonical_name": "copper ion import into ascospore-type prospore", "definition": "OBSOLETE. Any copper ion import that takes place in ascospore-type prospore. [GOC:TermGenie]"}
{"concept_id": "C3546505", "aliases": ["INO80-type complex location"], "types": ["T026"], "canonical_name": "INO80-type complex", "definition": "A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. [GOC:rb, PMID:19355820]"}
{"concept_id": "C3546506", "aliases": ["TRAPPIII protein complex location"], "types": ["T026"], "canonical_name": "TRAPPIII protein complex", "definition": "A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins. [GOC:bhm, PMID:20375281, PMID:22669257]"}
{"concept_id": "C3546507", "aliases": ["TRAPPII protein complex location"], "types": ["T026"], "canonical_name": "TRAPPII protein complex", "definition": "A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself. [GOC:bhm, PMID:20375281, PMID:22669257]"}
{"concept_id": "C3546508", "aliases": ["TRAPP core complex location", "TRAPP core complex", "TRAPPI protein complex location"], "types": ["T026"], "canonical_name": "TRAPPI protein complex", "definition": "A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast. [GOC:bhm, PMID:20375281, PMID:22669257]"}
{"concept_id": "C3546509", "aliases": ["Dxr protein complex location", "1-deoxy-D-xylulose 5-phosphate reductoisomerase complex location", "1-deoxy-D-xylulose 5-phosphate reductoisomerase complex"], "types": ["T026"], "canonical_name": "Dxr protein complex", "definition": "A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). [GOC:bhm, PMID:15339150]"}
{"concept_id": "C3546510", "aliases": ["Bam protein complex location", "OMP complex location", "OMP complex"], "types": ["T026"], "canonical_name": "Bam protein complex", "definition": "Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex. [GOC:bhm, PMID:20378773]"}
{"concept_id": "C3546511", "aliases": ["RPAP3/R2TP/prefoldin-like complex location"], "types": ["T026"], "canonical_name": "RPAP3/R2TP/prefoldin-like complex", "definition": "A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity. [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846]"}
{"concept_id": "C3546512", "aliases": ["maltose ATP-binding cassette transporter complex", "maltose ABC transporter complex location", "maltose ATP-binding cassette transporter complex location", "maltose transport complex location", "maltose ABC transporter complex"], "types": ["T026"], "canonical_name": "maltose transport complex", "definition": "Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. [PMID:18033289]"}
{"concept_id": "C3546513", "aliases": ["T5SS complex location", "type V protein secretion system complex location", "T5SS complex"], "types": ["T026"], "canonical_name": "type V protein secretion system complex", "definition": "A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). [GOC:bf, GOC:bhm, PMID:15119822, PMID:15590781]"}
{"concept_id": "C3546514", "aliases": ["IFN-gamma-activated inhibitor of translation complex", "IFN-gamma-activated inhibitor of translation complex location", "GAIT complex location", "gamma interferon-activated inhibitor of translation complex location", "gamma interferon-activated inhibitor of translation complex"], "types": ["T026"], "canonical_name": "GAIT complex", "definition": "A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. [GOC:br, PMID:15479637, PMID:23071094]"}
{"concept_id": "C3546515", "aliases": ["MCM4/6/7 complex", "MCM4/6/7 complex location", "MCM core complex location"], "types": ["T026"], "canonical_name": "MCM core complex", "definition": "A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated. [GOC:mah, PMID:10770926, PMID:15007098, PMID:9305914]"}
{"concept_id": "C3546516", "aliases": ["MCM8-MCM9 complex location"], "types": ["T026"], "canonical_name": "MCM8-MCM9 complex", "definition": "A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links. [GOC:sp, PMID:22771115, PMID:22771120]"}
{"concept_id": "C3546517", "aliases": ["CIA complex location"], "types": ["T026"], "canonical_name": "CIA complex", "definition": "The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity. [GOC:sp, PMID:22678362]"}
{"concept_id": "C3546518", "aliases": ["TAM protein secretion complex location", "translocation and assembly module protein complex location", "translocation and assembly module protein complex"], "types": ["T026"], "canonical_name": "TAM protein secretion complex", "definition": "A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane. [GOC:am, PMID:22466966]"}
{"concept_id": "C3546519", "aliases": ["IPI complex location", "IPI complex", "Rix1 complex location"], "types": ["T026"], "canonical_name": "Rix1 complex", "definition": "A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes. [GOC:vw, PMID:14759368, PMID:15260980, PMID:21385875]"}
{"concept_id": "C3546520", "aliases": ["CHD-type complex location"], "types": ["T026"], "canonical_name": "CHD-type complex", "definition": "A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. [GOC:krc, GOC:tb, PMID:17350655]"}
{"concept_id": "C3546522", "aliases": ["CERF complex location"], "types": ["T026"], "canonical_name": "CERF complex", "definition": "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters. [GOC:krc]"}
{"concept_id": "C3546523", "aliases": ["NoRC complex location"], "types": ["T026"], "canonical_name": "NoRC complex", "definition": "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters. [GOC:krc]"}
{"concept_id": "C3546524", "aliases": ["WICH complex location"], "types": ["T026"], "canonical_name": "WICH complex", "definition": "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair. [GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179]"}
{"concept_id": "C3546525", "aliases": ["calcium ion-transporting ATPase complex location"], "types": ["T026"], "canonical_name": "calcium ion-transporting ATPase complex", "definition": "Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in). [GOC:BHF]"}
{"concept_id": "C3546526", "aliases": ["cation-transporting ATPase complex location"], "types": ["T026"], "canonical_name": "cation-transporting ATPase complex", "definition": "Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). [GOC:BHF]"}
{"concept_id": "C3546527", "aliases": ["SIP complex location", "SIP complex", "striatin interacting phosphatase and kinase complex location", "striatin interacting phosphatase and kinase complex", "FAR/SIN/STRIPAK complex location"], "types": ["T026"], "canonical_name": "FAR/SIN/STRIPAK complex", "definition": "A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body. [GOC:vw, PMID:21561862, PMID:22119525]"}
{"concept_id": "C3546530", "aliases": ["SSB complex", "SSB complex location", "single-stranded DNA-binding protein complex location"], "types": ["T026"], "canonical_name": "single-stranded DNA-binding protein complex", "definition": "A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair. [GOC:jl, UniProt:P0AGE0]"}
{"concept_id": "C3546531", "aliases": ["DNA polymerase III, core complex location"], "types": ["T026"], "canonical_name": "DNA polymerase III, core complex", "definition": "The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities. [GOC:jl, UniProt:P06710]"}
{"concept_id": "C3546532", "aliases": ["DNA polymerase III, beta sliding clamp processivity factor complex location"], "types": ["T026"], "canonical_name": "DNA polymerase III, beta sliding clamp processivity factor complex", "definition": "A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species. [GOC:jl, UniProt:O73947]"}
{"concept_id": "C3546533", "aliases": ["Ost alpha-Ost beta complex", "SLC51 complex", "Ost-alpha/Ost-beta complex location", "SLC51 complex location", "Ost alpha-Ost beta complex location"], "types": ["T026"], "canonical_name": "Ost-alpha/Ost-beta complex", "definition": "A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity. [PMID:17650074, PMID:22535958]"}
{"concept_id": "C3546534", "aliases": ["HICS complex location"], "types": ["T026"], "canonical_name": "HICS complex", "definition": "A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins. [PMID:22623719]"}
{"concept_id": "C3546535", "aliases": ["Dsc E3 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "Dsc E3 ubiquitin ligase complex", "definition": "An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism. [GOC:mah, GOC:vw, PMID:21504829]"}
{"concept_id": "C3546536", "aliases": ["sulfopyruvate decarboxylase complex location"], "types": ["T026"], "canonical_name": "sulfopyruvate decarboxylase complex", "definition": "A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis. [GOC:mengo_curators, PMID:10940029]"}
{"concept_id": "C3546537", "aliases": ["methylthiol:coenzyme M methyl transferase complex location", "methylthiol:CoM methyltransferase complex location", "methylthiol coenzyme M methyl transferase complex location", "methylthiol coenzyme M methyl transferase complex", "methylthiol:coenzyme M methyl transferase complex", "methylthiol:coenzyme M methyltransferase complex location", "methylthiol:CoM methyltransferase complex"], "types": ["T026"], "canonical_name": "methylthiol:coenzyme M methyltransferase complex", "definition": "A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis. [GOC:mengo_curators, PMID:11073950, PMID:9371433]"}
{"concept_id": "C3546538", "aliases": ["methanophenazine reducing hydrogenase complex location"], "types": ["T026"], "canonical_name": "methanophenazine reducing hydrogenase complex", "definition": "A protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides. [GOC:mengo_curators, PMID:9555882]"}
{"concept_id": "C3546539", "aliases": ["hydrogen:coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide oxidoreductase complex", "coenzyme M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase complex location", "hydrogen:coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide oxidoreductase complex location", "coenzyme M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase complex", "CoB-CoM heterodisulfide reductase complex location"], "types": ["T026"], "canonical_name": "CoB-CoM heterodisulfide reductase complex", "definition": "A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine. [GOC:mengo_curators, PMID:8119281, PMID:8174566, PMID:9063468]"}
{"concept_id": "C3546540", "aliases": ["N5-methyltetrahydromethanopterin-coenzyme M methyltransferase complex", "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex location", "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex", "N5-methyltetrahydromethanopterin-coenzyme M methyltransferase complex location", "methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex location"], "types": ["T026"], "canonical_name": "methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex", "definition": "A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis. [GOC:mengo_curators, PMID:8477726]"}
{"concept_id": "C3546541", "aliases": ["formyl-methanofuran dehydrogenase (molybdenum enzyme) complex location"], "types": ["T026"], "canonical_name": "formyl-methanofuran dehydrogenase (molybdenum enzyme) complex", "definition": "A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis. [GOC:mengo_curators, PMID:1915887, PMID:8954165]"}
{"concept_id": "C3546542", "aliases": ["formyl-methanofuran dehydrogenase (tungsten enzyme) complex location"], "types": ["T026"], "canonical_name": "formyl-methanofuran dehydrogenase (tungsten enzyme) complex", "definition": "A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis. [GOC:mengo_curators, PMID:8125106, PMID:8575452]"}
{"concept_id": "C3546543", "aliases": ["methyl coenzyme M reductase complex location"], "types": ["T026"], "canonical_name": "methyl coenzyme M reductase complex", "definition": "A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis. [GOC:mengo_curators, PMID:9367957]"}
{"concept_id": "C3546544", "aliases": ["FO-synthase complex location", "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex location", "FO-synthase complex"], "types": ["T026"], "canonical_name": "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex", "definition": "A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420. [GOC:mengo_curators, PMID:14593448]"}
{"concept_id": "C3546545", "aliases": ["Trr/COMPASS-like complex location", "MLL3/4 complex location", "Trr/COMPASS-like complex"], "types": ["T026"], "canonical_name": "MLL3/4 complex", "definition": "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species. [GOC:sart, PMID:21875999]"}
{"concept_id": "C3546546", "aliases": ["MLL1/2 complex location", "Trx-containing complex location", "Trx-containing complex"], "types": ["T026"], "canonical_name": "MLL1/2 complex", "definition": "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. [GOC:sart, PMID:21875999]"}
{"concept_id": "C3546547", "aliases": ["DBIRD complex location"], "types": ["T026"], "canonical_name": "DBIRD complex", "definition": "A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD. [GOC:sp, PMID:22446626]"}
{"concept_id": "C3546548", "aliases": ["adaptor protein-5 adaptor complex", "adaptor protein-5 adaptor complex location", "AP-5 adaptor complex location"], "types": ["T026"], "canonical_name": "AP-5 adaptor complex", "definition": "An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo. [PMID:22022230]"}
{"concept_id": "C3546549", "aliases": ["starch utilization system complex location", "Sus complex location", "Sus complex"], "types": ["T026"], "canonical_name": "starch utilization system complex", "definition": "A bacterial cell envelope-associated multiprotein system, which binds and degrades starch. [GOC:mengo_curators, GOC:tt, PMID:19553672]"}
{"concept_id": "C3546550", "aliases": ["Ni-Fe hydrogenase complex", "nickel-iron hydrogenase complex location", "[Ni-Fe] hydrogenase complex location", "nickel-iron hydrogenase complex", "Ni-Fe hydrogenase complex location"], "types": ["T026"], "canonical_name": "[Ni-Fe] hydrogenase complex", "definition": "A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer. [GOC:mengo_curators, GOC:tt, PMID:8936309]"}
{"concept_id": "C3546551", "aliases": ["secondary cell-wall cellulose synthase complex", "secondary cell wall CESA complex location", "secondary cell-wall cellulose synthase complex location", "secondary cell wall CESA complex", "secondary cell wall cellulose synthase complex location"], "types": ["T026"], "canonical_name": "secondary cell wall cellulose synthase complex", "definition": "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4. [GOC:mengo_curators, GOC:tt, PMID:21307367]"}
{"concept_id": "C3546552", "aliases": ["primary cell wall CESA complex location", "primary cell wall CESA complex", "primary cell-wall cellulose synthase complex location", "primary cell-wall cellulose synthase complex", "primary cell wall cellulose synthase complex location"], "types": ["T026"], "canonical_name": "primary cell wall cellulose synthase complex", "definition": "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein. [GOC:mengo_curators, GOC:tt, PMID:17878302, PMID:21307367]"}
{"concept_id": "C3546553", "aliases": ["virus terminase complex location", "virus terminase complex", "viral terminase complex location"], "types": ["T026"], "canonical_name": "viral terminase complex", "definition": "A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides. [GOC:bf, GOC:bm, GOC:jl, GOC:mlg]"}
{"concept_id": "C3546554", "aliases": ["Vms1p-Cdc48p-Npl4p complex", "Vms1p-Cdc48p-Npl4p complex location", "Vms1-Cdc48-Npl4 complex", "Cdc48p-Npl4p-Vms1p complex", "Cdc48p-Npl4p-Vms1p complex location", "Vms1-Cdc48-Npl4 complex location", "Cdc48p-Npl4p-Vms1p AAA ATPase complex location"], "types": ["T026"], "canonical_name": "Cdc48p-Npl4p-Vms1p AAA ATPase complex", "definition": "A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p. [GOC:rn, PMID:21070972, PMID:21936843]"}
{"concept_id": "C3546555", "aliases": ["ISWI-type complex location"], "types": ["T026"], "canonical_name": "ISWI-type complex", "definition": "Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair. [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]"}
{"concept_id": "C3546556", "aliases": ["cyclin K-CDK13 complex location"], "types": ["T026"], "canonical_name": "cyclin K-CDK13 complex", "definition": "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [PMID:22012619]"}
{"concept_id": "C3546557", "aliases": ["cyclin K-CDK12 complex location"], "types": ["T026"], "canonical_name": "cyclin K-CDK12 complex", "definition": "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [PMID:22012619]"}
{"concept_id": "C3546558", "aliases": ["zona pellucida receptor complex location"], "types": ["T026"], "canonical_name": "zona pellucida receptor complex", "definition": "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction. [GOC:hjd, PMID:21880732]"}
{"concept_id": "C3546559", "aliases": ["Nup170 complex location", "Nup170 complex"], "types": ["T026"], "canonical_name": "nuclear pore inner ring", "definition": "A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex. [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]"}
{"concept_id": "C3546643", "aliases": ["tensidol A biosynthesis", "tensidol A formation", "tensidol A synthesis", "tensidol A anabolism"], "types": ["T044"], "canonical_name": "tensidol A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tensidol A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3546646", "aliases": ["protein localization to linear eisosome"], "types": ["T043"], "canonical_name": "protein localization to eisosome filament", "definition": "A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1. [GOC:mah, GOC:vw, PMID:22869600, PMID:23722945]"}
{"concept_id": "C3546647", "aliases": ["cellular response to 3-amino-1,2,4-triazole"], "types": ["T043"], "canonical_name": "cellular response to amitrole", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus. [GOC:mah]"}
{"concept_id": "C3546648", "aliases": [], "types": ["T026"], "canonical_name": "Pick body", "definition": "Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E. [NIF_Subcellular:nlx_subcell_20090102]"}
{"concept_id": "C3546649", "aliases": ["TERRA transcription"], "types": ["T045"], "canonical_name": "telomeric repeat-containing RNA transcription", "definition": "The synthesis of telomeric repeat-containing RNA from a DNA template. A telomere is a complex of DNA and proteins that seals the end of a chromosome. [GOC:al, PMID:22139915]"}
{"concept_id": "C3546650", "aliases": ["positive regulation of ferulate degradation", "upregulation of ferulate breakdown", "up-regulation of ferulate degradation", "positive regulation of ferulate catabolism", "up regulation of ferulate catabolism", "positive regulation of ferulate breakdown", "up-regulation of ferulate catabolic process", "activation of ferulate catabolism", "activation of ferulate breakdown", "up regulation of ferulate degradation", "upregulation of ferulate catabolic process", "activation of ferulate degradation", "upregulation of ferulate catabolism", "up-regulation of ferulate catabolism", "up regulation of ferulate breakdown", "up-regulation of ferulate breakdown", "upregulation of ferulate degradation", "up regulation of ferulate catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of ferulate catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of ferulate catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3546651", "aliases": ["orlandin biosynthesis", "orlandin formation", "orlandin anabolism", "orlandin synthesis"], "types": ["T044"], "canonical_name": "orlandin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of orlandin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3546652", "aliases": [], "types": ["T043"], "canonical_name": "asymmetric protein localization to old mitotic spindle pole body", "definition": "Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically. [GOC:dph, GOC:vw]"}
{"concept_id": "C3546653", "aliases": [], "types": ["T043"], "canonical_name": "response to reverse transcriptase inhibitor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus. [GOC:dph]"}
{"concept_id": "C3546654", "aliases": ["glomerular visceral epithelial cell migration"], "types": ["T043"], "canonical_name": "podocyte cell migration", "definition": "The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell. [GOC:pm, PMID:21402783]"}
{"concept_id": "C3546655", "aliases": [], "types": ["T044"], "canonical_name": "arg-arg specific dibasic protein processing", "definition": "Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein. [GOC:al]"}
{"concept_id": "C3546656", "aliases": ["inhibition of emodin formation", "down regulation of emodin biosynthetic process", "negative regulation of emodin synthesis", "down regulation of emodin anabolism", "down regulation of emodin synthesis", "downregulation of emodin anabolism", "inhibition of emodin anabolism", "down regulation of emodin formation", "downregulation of emodin synthesis", "down-regulation of emodin biosynthetic process", "down-regulation of emodin formation", "down-regulation of emodin anabolism", "downregulation of emodin biosynthetic process", "downregulation of emodin biosynthesis", "negative regulation of emodin biosynthesis", "down-regulation of emodin synthesis", "inhibition of emodin biosynthesis", "inhibition of emodin synthesis", "down regulation of emodin biosynthesis", "negative regulation of emodin anabolism", "downregulation of emodin formation", "negative regulation of emodin formation", "down-regulation of emodin biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of emodin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of emodin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3546657", "aliases": ["zeaxanthin metabolism"], "types": ["T044"], "canonical_name": "zeaxanthin metabolic process", "definition": "The chemical reactions and pathways involving zeaxanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]"}
{"concept_id": "C3546658", "aliases": ["phytoene catabolism", "phytoene degradation", "phytoene breakdown"], "types": ["T044"], "canonical_name": "phytoene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phytoene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799]"}
{"concept_id": "C3546659", "aliases": ["mitomycin C metabolism"], "types": ["T044"], "canonical_name": "mitomycin C metabolic process", "definition": "The chemical reactions and pathways involving mitomycin C. [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135]"}
{"concept_id": "C3546660", "aliases": ["oxytetracycline metabolism"], "types": ["T044"], "canonical_name": "oxytetracycline metabolic process", "definition": "The chemical reactions and pathways involving oxytetracycline. [GOC:TermGenie, GOC:yaf, PMID:8163168]"}
{"concept_id": "C3546661", "aliases": ["prephenate(2-) metabolism", "prephenate metabolism"], "types": ["T044"], "canonical_name": "prephenate(2-) metabolic process", "definition": "The chemical reactions and pathways involving prephenate(2-). [GOC:TermGenie, GOC:yaf, PMID:16752890]"}
{"concept_id": "C3546662", "aliases": ["transcription factor breakdown", "transcription factor catabolism", "proteasome-mediated transcription factor catabolism", "transcription factor degradation", "sequence-specific DNA binding transcription factor catabolic process"], "types": ["T044"], "canonical_name": "transcription factor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:al, GOC:vw, PMID:22833559]"}
{"concept_id": "C3546663", "aliases": [], "types": ["T026"], "canonical_name": "Schaffer axon collateral", "definition": "Part of axon of a CA3 pyramidal neuron that projects to hippocampal area CA1. [NIF_Subcellular:nlx_subcell_20090511]"}
{"concept_id": "C3546664", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. [EC:1.6.3.-]"}
{"concept_id": "C3546665", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial fragmentation involved in apoptotic process", "definition": "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form. [GOC:mtg_apoptosis, GOC:rk, PMID:12867994]"}
{"concept_id": "C3546666", "aliases": ["histone H2A monoubiquitination (H2A-K119)"], "types": ["T044"], "canonical_name": "histone H2A-K119 monoubiquitination", "definition": "The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms. [GOC:sp, PMID:15386022]"}
{"concept_id": "C3546667", "aliases": ["avascular cornea development"], "types": ["T042"], "canonical_name": "avascular cornea development in camera-type eye", "definition": "The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees. [GOC:uh, PMID:16849433, PMID:17051153]"}
{"concept_id": "C3546668", "aliases": ["cellular response to lowered oxygen levels"], "types": ["T043"], "canonical_name": "cellular response to decreased oxygen levels", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. [GOC:al]"}
{"concept_id": "C3546669", "aliases": [], "types": ["T040"], "canonical_name": "response to diuretic", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function. [GOC:hp]"}
{"concept_id": "C3546671", "aliases": [], "types": ["T043"], "canonical_name": "contractile ring localization", "definition": "The process in which a contractile ring is assembled and/or maintained in a specific location. [GOC:mah, GOC:vw]"}
{"concept_id": "C3546673", "aliases": [], "types": ["T044"], "canonical_name": "dopamine neurotransmitter receptor activity", "definition": "Combining with the neurotransmitter dopamine to initiate a change in cell activity. [GOC:PARL, IUPHAR_GPCR:1282, PMID:21711983]"}
{"concept_id": "C3546675", "aliases": ["5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "kojic acid synthesis", "kojic acid formation", "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "kojic acid biosynthesis", "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "kojic acid anabolism"], "types": ["T044"], "canonical_name": "kojic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of kojic acid. [GOC:di]"}
{"concept_id": "C3546676", "aliases": ["5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolism", "kojic acid metabolism", "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolic process"], "types": ["T044"], "canonical_name": "kojic acid metabolic process", "definition": "The chemical reactions and pathways involving kojic acid. [GOC:di]"}
{"concept_id": "C3546677", "aliases": ["positive regulation of ciliary cell motility"], "types": ["T043"], "canonical_name": "positive regulation of cilium-dependent cell motility", "definition": "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility. [GOC:cilia, GOC:jl]"}
{"concept_id": "C3546678", "aliases": [], "types": ["T026"], "canonical_name": "perforation plate", "definition": "A cell wall part that is the part of a wall of a vessel member and bears one or more openings (perforations). [GOC:PO_curators, ISBN:0471245194]"}
{"concept_id": "C3546679", "aliases": [], "types": ["T039"], "canonical_name": "stomatal opening", "definition": "The process of opening of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. [PMID:21749899]"}
{"concept_id": "C3546680", "aliases": [], "types": ["T039"], "canonical_name": "seed dehydration", "definition": "The seed development process whose outcome is the drying of a maturing seed. [PMID:20138563]"}
{"concept_id": "C3546681", "aliases": ["intrastrand DNA recombination"], "types": ["T045"], "canonical_name": "intrachromosomal DNA recombination", "definition": "The process of DNA recombination occurring within a single chromosome. [PMID:7748165]"}
{"concept_id": "C3546682", "aliases": [], "types": ["T043"], "canonical_name": "energy quenching", "definition": "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted by nonphotochemical quenching or chlorophyll fluorescence. [PMID:10938857]"}
{"concept_id": "C3546683", "aliases": ["ground tissue patterning"], "types": ["T042"], "canonical_name": "ground tissue pattern formation", "definition": "The regionalization process that gives rise to the patterning of the ground tissue. [PMID:23444357]"}
{"concept_id": "C3546684", "aliases": [], "types": ["T026"], "canonical_name": "bacterial degradosome", "definition": "The degradosome is a protein complex playing a key role in mRNA degradation and RNA processing. It includes a RNA helicase, a 3'-5' phosphate-dependent PNPase and a RNase E bound-enolase. [GOC:bhm, PMID:21805185]"}
{"concept_id": "C3546685", "aliases": [], "types": ["T039"], "canonical_name": "fruit valve development", "definition": "The process whose specific outcome is the progression of the fruit valve over time, from its formation to the mature structure. The fruit valve is a part of a fruit that splits apart when the fruit dehisces. [PMID:23133401, PO:0000033]"}
{"concept_id": "C3546686", "aliases": [], "types": ["T039"], "canonical_name": "fruit replum development", "definition": "The process whose specific outcome is the progression of the fruit replum over time, from its formation to the mature structure. The fruit replum is a portion of fruit placenta tissue that divides a fruit into two or more chambers and develops from a replum. [PMID:23133401, PO:0025267]"}
{"concept_id": "C3546687", "aliases": [], "types": ["T044"], "canonical_name": "phenylacetaldehyde synthase activity", "definition": "Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2. [MetaCyc:RXN-8990, PMID:16766535, PMID:23204519]"}
{"concept_id": "C3546688", "aliases": [], "types": ["T043"], "canonical_name": "response to temozolomide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus. [GOC:hp]"}
{"concept_id": "C3546689", "aliases": [], "types": ["T045"], "canonical_name": "DNA-5-methylcytosine glycosylase activity", "definition": "Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site. [PMID:23316050]"}
{"concept_id": "C3546690", "aliases": ["endoplasmic reticulum to chloroplast lipid transport", "ER to chloroplast lipid trafficking"], "types": ["T043"], "canonical_name": "ER to chloroplast lipid transport", "definition": "The directed movement of a lipid from the endoplasmic reticulum (ER) to the chloroplast. [PMID:18689504]"}
{"concept_id": "C3546691", "aliases": ["PKC activation", "protein kinase C activation"], "types": ["T044"], "canonical_name": "activation of protein kinase C activity", "definition": "Any process that initiates the activity of the inactive enzyme protein kinase C. [PMID:3156004]"}
{"concept_id": "C3546692", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidic acid transporter activity"}
{"concept_id": "C3546693", "aliases": ["retrograde dense core granule trafficking", "retrograde dense core granule transport"], "types": ["T043"], "canonical_name": "retrograde neuronal dense core vesicle transport", "definition": "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body. [GOC:kmv, PMID:23358451, PMID:24762653]"}
{"concept_id": "C3546694", "aliases": ["anterograde dense core granule transport", "anterograde dense core granule trafficking"], "types": ["T043"], "canonical_name": "anterograde neuronal dense core vesicle transport", "definition": "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse. [GOC:kmv, PMID:23358451]"}
{"concept_id": "C3546695", "aliases": [], "types": ["T026"], "canonical_name": "spindle matrix", "definition": "A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis. [GOC:ans, PMID:19273613, PMID:22855526]"}
{"concept_id": "C3546696", "aliases": [], "types": ["T042"], "canonical_name": "sclerotium development", "definition": "The process whose specific outcome is the progression of the sclerotium over time, from its formation to the mature structure. A sclerotium is a mycelial resting body, resistant to adverse environmental conditions. [GOC:di, PMID:21148914]"}
{"concept_id": "C3546697", "aliases": ["protein localisation to lipid droplet", "protein localisation to lipid body", "protein localisation to adiposome", "protein localization to lipid particle", "protein localisation to lipid particle", "protein localization to adiposome", "protein localization to lipid body"], "types": ["T043"], "canonical_name": "protein localization to lipid droplet", "definition": "A process in which a protein is transported to, or maintained in, a location on or within a lipid droplet. [GOC:sart, PMID:22505614]"}
{"concept_id": "C3546698", "aliases": [], "types": ["T045"], "canonical_name": "5' deoxyribonuclease (pyrimidine dimer) activity", "definition": "Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate. [EC:3.1.25.-, GOC:al, PMID:9708997]"}
{"concept_id": "C3546699", "aliases": ["glycerol dehydrogenase activity, NAD or NADP as acceptor"], "types": ["T044"], "canonical_name": "glycerol dehydrogenase [NAD(P)+] activity", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced. [PMID:22979944]"}
{"concept_id": "C3546700", "aliases": ["sub-surface cisternae"], "types": ["T026"], "canonical_name": "sub-surface cisterna", "definition": "Specialization of the hypolemmal cisterna consisting of either single profiles or closely apposed stacks of endoplasmic reticulum in which the lumen is obliterated, lying 10-20 nm beneath the plasma membrane. [ISBN:0195065719, NIF_Subcellular:sao128470897]"}
{"concept_id": "C3546701", "aliases": ["hypolemmal cisternae"], "types": ["T026"], "canonical_name": "hypolemmal cisterna", "definition": "Specialized part of the smooth endoplasmic reticulum that closely underlies the plasma membrane, usually within 60 nm or closer. [ISBN:0195065719, NIF_Subcellular:sao1634374950]"}
{"concept_id": "C3546702", "aliases": [], "types": ["T026"], "canonical_name": "Lewy body core", "definition": "The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments. [NIF_Subcellular:sao6587439252]"}
{"concept_id": "C3546703", "aliases": [], "types": ["T043"], "canonical_name": "calcium ion import into sarcoplasmic reticulum", "definition": "The directed movement of calcium ions into a sarcoplasmic reticulum. [GOC:BHF, PMID:17286271]"}
{"concept_id": "C3546705", "aliases": ["calcium ion export from cell", "calcium ion efflux from cell"], "types": ["T043"], "canonical_name": "calcium ion export across plasma membrane", "definition": "The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:mah, PMID:2145281]"}
{"concept_id": "C3546706", "aliases": ["branch point of dendrite"], "types": ["T026"], "canonical_name": "dendritic branch point", "definition": "The part of a dendritic tree where it branches, giving rise to a dendritic branch. [GOC:aruk, GOC:bc, NIF_Subcellular:sao1348591767]"}
{"concept_id": "C3546707", "aliases": [], "types": ["T026"], "canonical_name": "parallel fiber", "definition": "A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium. [ISBN:0195159551, NIF_Subcellular:nlx_330]"}
{"concept_id": "C3546708", "aliases": [], "types": ["T026"], "canonical_name": "pinceau fiber", "definition": "Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment. [NIF_Subcellular:sao109906988]"}
{"concept_id": "C3546709", "aliases": ["peri cellular basket", "peri-cellular basket"], "types": ["T026"], "canonical_name": "pericellular basket", "definition": "Ramification of basket cell axon surrounding cell bodies, forming the characteristic pericellular baskets from which the cell class derives its name. [NIF_Subcellular:sao413722576]"}
{"concept_id": "C3546710", "aliases": [], "types": ["T026"], "canonical_name": "S bouton", "definition": "Synaptic bouton found in the ventral horn of the spinal cord. S boutons range in diameter from 0.5 to 8 um and contain spherical synaptic vesicles. [NIF_Subcellular:nlx_subcell_100207]"}
{"concept_id": "C3546711", "aliases": [], "types": ["T026"], "canonical_name": "hippocampal mossy fiber expansion", "definition": "Synaptic expansion of hippocampal mossy fiber axon that makes contact with the thorny excrescences of hippocampal CA3 pyramidal cell dendrites. [NIF_Subcellular:nlx_subcell_1005002]"}
{"concept_id": "C3546712", "aliases": [], "types": ["T026"], "canonical_name": "F bouton", "definition": "Synaptic bouton found in the ventral horn of the spinal cord. F boutons range in diameter from 0.5 to 7 um and contain flattened or pleomorphic synaptic vesicles. [NIF_Subcellular:nlx_subcell_100206]"}
{"concept_id": "C3546713", "aliases": [], "types": ["T026"], "canonical_name": "C bouton", "definition": "Synaptic bouton found in spinal cord on the soma and proximal dendrites of motor neurons. [NIF_Subcellular:nlx_subcell_100208]"}
{"concept_id": "C3546714", "aliases": [], "types": ["T026"], "canonical_name": "mitotic spindle midzone", "definition": "The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner. [GOC:mtg_cell_cycle, GOC:vw]"}
{"concept_id": "C3546716", "aliases": [], "types": ["T026"], "canonical_name": "recurrent axon collateral", "definition": "Axon collateral that ramifies in the area of the soma of the cell of origin. [NIF_Subcellular:sao1642494436]"}
{"concept_id": "C3546717", "aliases": [], "types": ["T043"], "canonical_name": "protein storage vacuole organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a protein storage vacuole, a storage vacuole that contains a lytic vacuole. [GOC:tb, PMID:21670741]"}
{"concept_id": "C3546718", "aliases": [], "types": ["T026"], "canonical_name": "tail portion of tanycyte", "definition": "Elongated process of a tanycyte, devoid of cytoplasmic extensions, that courses through the hypothalamic nuclei to form small endfoot processes that terminate either on blood vessels or at the pial surface of the brain. A tanycyte is a specialized elongated ventricular ependymal cell. [ISBN:0195065719, NIF_Subcellular:sao1749953771]"}
{"concept_id": "C3546719", "aliases": [], "types": ["T026"], "canonical_name": "somatic portion of tanycyte", "definition": "Portion of a tanycyte that lies within the ependyma and contains the nucleus. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. [ISBN:0195065719, NIF_Subcellular:sao401910342]"}
{"concept_id": "C3546720", "aliases": [], "types": ["T026"], "canonical_name": "neck portion of tanycyte", "definition": "Elongated portion of a tanycyte that sticks into the periventricular layer of neuropil where it appears to contact a blood vessel; characterized by numerous cytoplasmic extensions. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. [ISBN:0195065719, NIF_Subcellular:sao901230115]"}
{"concept_id": "C3546721", "aliases": [], "types": ["T026"], "canonical_name": "ensheathing process", "definition": "A cell projection (often from glial cells such as Schwann cells) that surrounds an unmyelinated axon or cell soma. [NIF_Subcellular:sao1376748732]"}
{"concept_id": "C3546722", "aliases": ["pre-synaptic grid"], "types": ["T026"], "canonical_name": "presynaptic grid", "definition": "A hexagonal array of electron dense particles attached to the cytoplasmic face of the presynaptic membrane. [ISBN:0716723808, NIF_Subcellular:sao1730664005]"}
{"concept_id": "C3546723", "aliases": ["laminated inclusion body"], "types": ["T026"], "canonical_name": "laminated body", "definition": "Inclusion body characterized by regularly spaced sheets of tubules arranged in a whorl pattern resembling a fingerprint. Laminated bodies have been observed in neurons of the lateral geniculate nucleus. [ISBN:0195065719, NIF_Subcellular:sao506721981]"}
{"concept_id": "C3546724", "aliases": [], "types": ["T043"], "canonical_name": "compound eye retinal cell apoptotic process", "definition": "Any apoptotic process in a compound eye retinal cell. [GOC:mtg_apoptosis, PMID:12021768]"}
{"concept_id": "C3546725", "aliases": [], "types": ["T043"], "canonical_name": "retinal cell apoptotic process", "definition": "Any apoptotic process in a retinal cell. [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675]"}
{"concept_id": "C3546726", "aliases": [], "types": ["T026"], "canonical_name": "neurosecretory vesicle", "definition": "A large cytoplasmic membrane-bounded vesicle with an electron dense granular core, up to 150-200 nm in diameter, found in neurosecretory cells in the hypothalamus. [ISBN:0195065719, NIF_Subcellular:sao2031592629]"}
{"concept_id": "C3546727", "aliases": [], "types": ["T026"], "canonical_name": "membrane stack", "definition": "A configuration of endoplasmic reticulum (ER) found in Purkinje cells in the cerebellum and in axons in the lateral vestibular nucleus, consisting of parallel and interconnecting tubules whose outer surfaces are covered by particles or ringlike structures. [ISBN:9780195065718, NIF_Subcellular:sao2114874506]"}
{"concept_id": "C3546728", "aliases": [], "types": ["T026"], "canonical_name": "amorphous vesicle", "definition": "A cytoplasmic membrane-bounded vesicle first described in dendrites, categorized by smooth membranes, electron-lucent interiors and irregular shapes. Sometimes occurs in clumps. Amorphous vesicles have been found to contain material taken up from the extracellular space, therefore suggesting that they may be part of the endosomal pathway. [NIF_Subcellular:sao1531915298, PMID:11896161]"}
{"concept_id": "C3546729", "aliases": [], "types": ["T026"], "canonical_name": "granular vesicle", "definition": "A cytoplasmic membrane-bounded vesicle of varying size, but usually larger than 45 nm, with an electron dense granular core, found in noradrenergic and peptidergic cells. [NIF_Subcellular:sao478230652]"}
{"concept_id": "C3546731", "aliases": ["IDP phosphatase activity", "inosine diphosphatase activity", "IDPase activity"], "types": ["T044"], "canonical_name": "inosine-diphosphatase activity", "definition": "Catalysis of the reaction: IDP + H2O = IMP + phosphate. [PMID:20385596, PMID:22849572, RHEA:35207]"}
{"concept_id": "C3546732", "aliases": [], "types": ["T044"], "canonical_name": "methylglyoxal reductase (NADPH-dependent, acetol producing)", "definition": "Catalysis of the reaction: H+ + methylglyoxal + NADPH <=> hydroxyacetone + NADP+. [EC:1.1.1.-, MetaCyc:RXN0-4281, PMID:16077126, RHEA:27986]"}
{"concept_id": "C3546733", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cysteine-type endopeptidase activity involved in apoptotic process", "definition": "Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process. [GOC:mtg_apoptosis, PMID:11943137]"}
{"concept_id": "C3546734", "aliases": [], "types": ["T043"], "canonical_name": "polyamine transmembrane transport", "definition": "The process in which a polyamine macromolecule is transported across a membrane. [GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3546735", "aliases": ["up regulation of CD95 signaling pathway", "up-regulation of FasR signaling pathway", "upregulation of Apo-1 signaling pathway", "positive regulation of Apo-1 signaling pathway", "up regulation of Fas signaling pathway", "positive regulation of CD95 signaling pathway", "up regulation of Apo-1 signaling pathway", "upregulation of Fas receptor signaling pathway", "upregulation of Fas signaling pathway", "up-regulation of Fas receptor signaling pathway", "up-regulation of CD95 signaling pathway", "upregulation of CD95 signaling pathway", "up-regulation of Fas signaling pathway", "up regulation of Fas receptor signaling pathway", "up regulation of FasR signaling pathway", "positive regulation of Fas receptor signaling pathway", "positive regulation of FasR signaling pathway", "upregulation of FasR signaling pathway", "up-regulation of Apo-1 signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of Fas signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of Fas signaling pathway. [GOC:TermGenie, PMID:17245429]"}
{"concept_id": "C3546736", "aliases": ["downregulation of CD95 signaling pathway", "negative regulation of Apo-1 signaling pathway", "downregulation of Apo-1 signaling pathway", "down-regulation of Fas receptor signaling pathway", "down regulation of Apo-1 signaling pathway", "down-regulation of Apo-1 signaling pathway", "negative regulation of Fas receptor signaling pathway", "down-regulation of CD95 signaling pathway", "down regulation of CD95 signaling pathway", "down-regulation of FasR signaling pathway", "down regulation of Fas signaling pathway", "negative regulation of FasR signaling pathway", "downregulation of Fas receptor signaling pathway", "down-regulation of Fas signaling pathway", "downregulation of Fas signaling pathway", "down regulation of FasR signaling pathway", "downregulation of FasR signaling pathway", "down regulation of Fas receptor signaling pathway", "negative regulation of CD95 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of Fas signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Fas signaling pathway. [GOC:TermGenie, PMID:17245429]"}
{"concept_id": "C3546737", "aliases": ["regulation of Apo-1 signaling pathway", "regulation of CD95 signaling pathway", "regulation of FasR signaling pathway", "regulation of Fas receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of Fas signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of Fas signaling pathway. [GOC:TermGenie, PMID:17245429]"}
{"concept_id": "C3546738", "aliases": ["up regulation of extrinsic apoptotic signaling pathway via death domain receptors", "up-regulation of extrinsic apoptotic signaling pathway via death domain receptors", "upregulation of extrinsic apoptotic signaling pathway via death domain receptors"], "types": ["T044"], "canonical_name": "positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "definition": "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. [GOC:TermGenie, PMID:17245429]"}
{"concept_id": "C3546739", "aliases": ["down-regulation of extrinsic apoptotic signaling pathway via death domain receptors", "downregulation of extrinsic apoptotic signaling pathway via death domain receptors", "down regulation of extrinsic apoptotic signaling pathway via death domain receptors"], "types": ["T044"], "canonical_name": "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. [GOC:TermGenie, PMID:17245429]"}
{"concept_id": "C3546740", "aliases": [], "types": ["T044"], "canonical_name": "regulation of extrinsic apoptotic signaling pathway via death domain receptors", "definition": "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. [GOC:TermGenie, PMID:17245429]"}
{"concept_id": "C3546741", "aliases": ["upregulation of seed dormancy process", "up regulation of seed dormancy process", "up-regulation of seed dormancy process"], "types": ["T040"], "canonical_name": "positive regulation of seed dormancy process", "definition": "Any process that activates or increases the frequency, rate or extent of seed dormancy process. [GOC:TermGenie, PMID:23378449]"}
{"concept_id": "C3546742", "aliases": ["downregulation of seed dormancy process", "down regulation of seed dormancy process", "down-regulation of seed dormancy process"], "types": ["T040"], "canonical_name": "negative regulation of seed dormancy process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of seed dormancy process. [GOC:TermGenie, PMID:23378449]"}
{"concept_id": "C3546743", "aliases": ["up regulation of hematopoietic stem cell differentiation", "up-regulation of hematopoietic stem cell differentiation", "up-regulation of haematopoietic stem cell differentiation", "upregulation of hemopoietic stem cell differentiation", "upregulation of haemopoietic stem cell differentiation", "upregulation of haematopoietic stem cell differentiation", "positive regulation of haemopoietic stem cell differentiation", "up-regulation of hemopoietic stem cell differentiation", "upregulation of hematopoietic stem cell differentiation", "positive regulation of hemopoietic stem cell differentiation", "up regulation of haemopoietic stem cell differentiation", "up regulation of hemopoietic stem cell differentiation", "up regulation of haematopoietic stem cell differentiation", "positive regulation of haematopoietic stem cell differentiation", "up-regulation of haemopoietic stem cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of hematopoietic stem cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation. [GOC:TermGenie, PMID:23403623]"}
{"concept_id": "C3546744", "aliases": ["negative regulation of hemopoietic stem cell differentiation", "down-regulation of hemopoietic stem cell differentiation", "down-regulation of haematopoietic stem cell differentiation", "downregulation of hematopoietic stem cell differentiation", "down regulation of haematopoietic stem cell differentiation", "downregulation of haematopoietic stem cell differentiation", "negative regulation of haematopoietic stem cell differentiation", "downregulation of hemopoietic stem cell differentiation", "down regulation of haemopoietic stem cell differentiation", "negative regulation of haemopoietic stem cell differentiation", "down-regulation of hematopoietic stem cell differentiation", "downregulation of haemopoietic stem cell differentiation", "down-regulation of haemopoietic stem cell differentiation", "down regulation of hemopoietic stem cell differentiation", "down regulation of hematopoietic stem cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of hematopoietic stem cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. [GOC:TermGenie, PMID:23403623]"}
{"concept_id": "C3546745", "aliases": ["regulation of haemopoietic stem cell differentiation", "regulation of hemopoietic stem cell differentiation", "regulation of haematopoietic stem cell differentiation"], "types": ["T038"], "canonical_name": "regulation of hematopoietic stem cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. [GOC:TermGenie, PMID:23403623]"}
{"concept_id": "C3546746", "aliases": ["positive regulation of hemopoietic stem cell proliferation", "upregulation of hematopoietic stem cell proliferation", "up-regulation of hemopoietic stem cell proliferation", "upregulation of hemopoietic stem cell proliferation", "up-regulation of hematopoietic stem cell proliferation", "up regulation of hemopoietic stem cell proliferation", "up regulation of hematopoietic stem cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of hematopoietic stem cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. [GOC:TermGenie, PMID:23403623]"}
{"concept_id": "C3546747", "aliases": ["negative regulation of hemopoietic stem cell proliferation", "downregulation of hematopoietic stem cell proliferation", "down regulation of hematopoietic stem cell proliferation", "down-regulation of hematopoietic stem cell proliferation", "down-regulation of hemopoietic stem cell proliferation", "downregulation of hemopoietic stem cell proliferation", "down regulation of hemopoietic stem cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of hematopoietic stem cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. [GOC:TermGenie, PMID:23403623]"}
{"concept_id": "C3546748", "aliases": ["regulation of hemopoietic stem cell proliferation"], "types": ["T038"], "canonical_name": "regulation of hematopoietic stem cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. [GOC:TermGenie, PMID:23403623]"}
{"concept_id": "C3546749", "aliases": ["regulation of NADPH metabolism", "regulation of NADP metabolism", "regulation of oxidized NADP metabolic process", "regulation of NADP (reduced) metabolic process", "regulation of reduced NADP metabolic process", "regulation of reduced NADP metabolism", "regulation of NADP (reduced) metabolism", "regulation of NADP (oxidized) metabolic process", "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolism", "regulation of oxidized NADP metabolism", "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolic process", "regulation of nicotinamide adenine dinucleotide phosphate metabolism", "regulation of NADPH metabolic process", "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolism", "regulation of nicotinamide adenine dinucleotide phosphate metabolic process", "regulation of NADP (oxidized) metabolism", "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolic process"], "types": ["T044"], "canonical_name": "regulation of NADP metabolic process", "definition": "Any process that modulates the frequency, rate or extent of NADP metabolic process. [GOC:TermGenie, PMID:23334421]"}
{"concept_id": "C3546750", "aliases": ["down-regulation of histone H3K18 acetylation", "inhibition of histone H3K18 acetylation", "down regulation of histone H3K18 acetylation", "downregulation of histone H3 acetylation at K18", "down-regulation of histone H3-K18 acetylation", "down regulation of histone H3-K18 acetylation", "down-regulation of histone H3 acetylation at K18", "down regulation of histone H3 acetylation at K18", "negative regulation of histone H3K18 acetylation", "negative regulation of histone H3 acetylation at K18", "downregulation of histone H3-K18 acetylation", "inhibition of histone H3 acetylation at K18", "downregulation of histone H3K18 acetylation"], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K18 acetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K18 acetylation. [GOC:TermGenie, PMID:22110608]"}
{"concept_id": "C3546751", "aliases": ["up-regulation of histone H3 acetylation at K18", "upregulation of histone H3 acetylation at K18", "up regulation of histone H3-K18 acetylation", "activation of histone H3K18 acetylation", "up regulation of histone H3K18 acetylation", "up-regulation of histone H3-K18 acetylation", "up regulation of histone H3 acetylation at K18", "positive regulation of histone H3K18 acetylation", "upregulation of histone H3-K18 acetylation", "up-regulation of histone H3K18 acetylation", "upregulation of histone H3K18 acetylation", "activation of histone H3 acetylation at K18", "positive regulation of histone H3 acetylation at K18"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K18 acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K18 acetylation. [GOC:TermGenie, PMID:22110608]"}
{"concept_id": "C3546752", "aliases": ["regulation of histone H3 acetylation at K18", "regulation of histone H3K18 acetylation"], "types": ["T044"], "canonical_name": "regulation of histone H3-K18 acetylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K18 acetylation. [GOC:TermGenie, PMID:22110608]"}
{"concept_id": "C3546753", "aliases": ["upregulation of cartilage condensation", "up regulation of cartilage condensation", "up-regulation of cartilage condensation"], "types": ["T043"], "canonical_name": "positive regulation of cartilage condensation", "definition": "Any process that activates or increases the frequency, rate or extent of cartilage condensation. [GOC:TermGenie, PMID:17202865]"}
{"concept_id": "C3546754", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cartilage condensation", "definition": "Any process that modulates the frequency, rate or extent of cartilage condensation. [GOC:TermGenie, PMID:17202865]"}
{"concept_id": "C3546755", "aliases": ["nitrate uptake", "nitrate influx"], "types": ["T043"], "canonical_name": "nitrate import", "definition": "The directed movement of nitrate into a cell or organelle. [GOC:TermGenie, PMID:22658680]"}
{"concept_id": "C3546756", "aliases": ["regulation of bacterial-type flagellum cell motility", "regulation of bacterial-type flagellar cell motility", "regulation of flagellin-based flagellar cell motility"], "types": ["T043"], "canonical_name": "regulation of bacterial-type flagellum-dependent cell motility", "definition": "Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility. [GOC:cilia, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3546757", "aliases": ["downregulation of ciliary cell motility", "down regulation of ciliary cell motility", "negative regulation of ciliary cell motility", "down-regulation of ciliary cell motility", "negative regulation of cilium cell motility"], "types": ["T043"], "canonical_name": "negative regulation of cilium-dependent cell motility", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility. [GOC:cilia, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3546758", "aliases": ["regulation of cilium cell motility", "regulation of ciliary cell motility"], "types": ["T043"], "canonical_name": "regulation of cilium-dependent cell motility", "definition": "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility. [GOC:cilia, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3546759", "aliases": ["regulation of ciliogenesis"], "types": ["T038"], "canonical_name": "regulation of cilium assembly", "definition": "Any process that modulates the frequency, rate or extent of cilium assembly. [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]"}
{"concept_id": "C3546760", "aliases": ["poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis", "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid anabolism", "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid formation", "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process", "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid synthesis", "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis"], "types": ["T044"], "canonical_name": "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid. [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828]"}
{"concept_id": "C3546761", "aliases": ["poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process", "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism", "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism"], "types": ["T044"], "canonical_name": "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process", "definition": "The chemical reactions and pathways involving poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid. [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828]"}
{"concept_id": "C3546762", "aliases": ["poly(glycerol phosphate) teichoic acid biosynthesis", "poly(glycerol phosphate) teichoic acid anabolism", "poly(glycerol phosphate) teichoic acid synthesis", "poly(glycerol phosphate) teichoic acid formation"], "types": ["T044"], "canonical_name": "poly(glycerol phosphate) teichoic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly(glycerol phosphate) teichoic acid. [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827]"}
{"concept_id": "C3546763", "aliases": ["poly(glycerol phosphate) teichoic acid metabolism"], "types": ["T044"], "canonical_name": "poly(glycerol phosphate) teichoic acid metabolic process", "definition": "The chemical reactions and pathways involving poly(glycerol phosphate) teichoic acid. [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827]"}
{"concept_id": "C3546764", "aliases": ["poly(ribitol phosphate) teichoic acid biosynthesis", "poly(ribitol phosphate) teichoic acid formation", "poly(ribitol phosphate) teichoic acid anabolism", "poly(ribitol phosphate) teichoic acid synthesis"], "types": ["T044"], "canonical_name": "poly(ribitol phosphate) teichoic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly(ribitol phosphate) teichoic acid. [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790]"}
{"concept_id": "C3546765", "aliases": ["poly(ribitol phosphate) teichoic acid metabolism"], "types": ["T044"], "canonical_name": "poly(ribitol phosphate) teichoic acid metabolic process", "definition": "The chemical reactions and pathways involving poly(ribitol phosphate) teichoic acid. [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790]"}
{"concept_id": "C3546766", "aliases": ["downregulation of protein biosynthetic process involved in ER stress response", "negative regulation of protein anabolism involved in response to endoplasmic reticulum stress", "negative regulation of protein formation involved in response to ER stress", "down-regulation of protein biosynthetic process involved in response to ER stress", "downregulation of protein biosynthetic process involved in response to endoplasmic reticulum stress", "negative regulation of protein biosynthesis involved in response to endoplasmic reticulum stress", "negative regulation of protein synthesis involved in response to ER stress", "negative regulation of protein synthesis involved in response to endoplasmic reticulum stress", "down-regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress", "negative regulation of protein formation involved in ER stress response", "negative regulation of protein biosynthetic process involved in ER stress response", "down-regulation of protein biosynthetic process involved in ER stress response", "negative regulation of translation involved in response to ER stress", "negative regulation of protein biosynthesis involved in response to ER stress", "negative regulation of protein biosynthesis involved in ER stress response", "down regulation of protein biosynthetic process involved in response to ER stress", "negative regulation of protein biosynthetic process involved in response to ER stress", "negative regulation of protein anabolism involved in ER stress response", "downregulation of protein biosynthetic process involved in response to ER stress", "negative regulation of protein anabolism involved in response to ER stress", "negative regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress", "down regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress", "down regulation of protein biosynthetic process involved in ER stress response", "negative regulation of translation involved in ER stress response", "negative regulation of protein formation involved in response to endoplasmic reticulum stress", "negative regulation of protein synthesis involved in ER stress response"], "types": ["T045"], "canonical_name": "negative regulation of translation in response to endoplasmic reticulum stress", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress. [GOC:dph, GOC:TermGenie, PMID:10882126]"}
{"concept_id": "C3546767", "aliases": ["upregulation of toxin transport", "up-regulation of toxin transport", "up regulation of toxin transport"], "types": ["T043"], "canonical_name": "positive regulation of toxin transport", "definition": "Any process that activates or increases the frequency, rate or extent of toxin transport. [GOC:dph, GOC:TermGenie, PMID:22792315]"}
{"concept_id": "C3546768", "aliases": ["downregulation of toxin transport", "down regulation of toxin transport", "down-regulation of toxin transport"], "types": ["T043"], "canonical_name": "negative regulation of toxin transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of toxin transport. [GOC:dph, GOC:TermGenie, PMID:22792315]"}
{"concept_id": "C3546769", "aliases": [], "types": ["T043"], "canonical_name": "regulation of toxin transport", "definition": "Any process that modulates the frequency, rate or extent of toxin transport. [GOC:dph, GOC:TermGenie, PMID:22792315]"}
{"concept_id": "C3546770", "aliases": ["negative regulation of proline formation", "inhibition of proline anabolism", "down-regulation of proline anabolism", "negative regulation of proline synthesis", "down-regulation of proline formation", "inhibition of proline formation", "down-regulation of proline biosynthetic process", "down regulation of proline synthesis", "down regulation of proline anabolism", "negative regulation of proline anabolism", "down regulation of proline biosynthetic process", "inhibition of proline synthesis", "down regulation of proline biosynthesis", "down regulation of proline formation", "downregulation of proline anabolism", "inhibition of proline biosynthesis", "downregulation of proline biosynthesis", "downregulation of proline biosynthetic process", "down-regulation of proline biosynthesis", "down-regulation of proline synthesis", "negative regulation of proline biosynthesis", "downregulation of proline formation", "downregulation of proline synthesis"], "types": ["T044"], "canonical_name": "negative regulation of proline biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of proline biosynthetic process. [GOC:TermGenie, PMID:23415322]"}
{"concept_id": "C3546771", "aliases": ["regulation of proline formation", "regulation of proline biosynthesis", "regulation of proline synthesis", "regulation of proline anabolism"], "types": ["T044"], "canonical_name": "regulation of proline biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of proline biosynthetic process. [GOC:TermGenie, PMID:23415322]"}
{"concept_id": "C3546772", "aliases": ["positive regulation of beta-amyloid formation", "up-regulation of beta-amyloid formation", "up regulation of beta-amyloid formation", "upregulation of beta-amyloid formation"], "types": ["T044"], "canonical_name": "positive regulation of amyloid-beta formation", "definition": "Any process that activates or increases the frequency, rate or extent of amyloid-beta formation. [GOC:dph, GOC:TermGenie, PMID:17098871]"}
{"concept_id": "C3546773", "aliases": ["regulation of beta-amyloid formation"], "types": ["T044"], "canonical_name": "regulation of amyloid-beta formation", "definition": "Any process that modulates the frequency, rate or extent of amyloid-beta formation. [GOC:dph, GOC:TermGenie, PMID:17098871]"}
{"concept_id": "C3546775", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid transmembrane transport", "definition": "The process in which a fatty acid is transported across a membrane. [GOC:rb, GOC:TermGenie, PMID:9395310]"}
{"concept_id": "C3546776", "aliases": ["homogentisate breakdown", "homogentisate catabolism", "homogentisate degradation"], "types": ["T044"], "canonical_name": "homogentisate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of homogentisate. [GOC:TermGenie, PMID:22980205]"}
{"concept_id": "C3546777", "aliases": ["homogentisate metabolism"], "types": ["T044"], "canonical_name": "homogentisate metabolic process", "definition": "The chemical reactions and pathways involving homogentisate. [GOC:TermGenie, PMID:22980205]"}
{"concept_id": "C3546778", "aliases": [], "types": ["T043"], "canonical_name": "toxin transport", "definition": "The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:TermGenie, PMID:17118486]"}
{"concept_id": "C3546779", "aliases": ["negative regulation of indoleacetic acid anabolism via tryptophan", "downregulation of indoleacetic acid anabolism via tryptophan", "down regulation of indoleacetic acid synthesis via tryptophan", "down regulation of indoleacetic acid anabolism via tryptophan", "inhibition of indoleacetic acid anabolism via tryptophan", "inhibition of indoleacetic acid synthesis via tryptophan", "downregulation of indoleacetic acid formation via tryptophan", "downregulation of indoleacetic acid biosynthetic process via tryptophan", "down-regulation of IAA biosynthetic process via tryptophan", "down-regulation of indoleacetic acid biosynthetic process via tryptophan", "inhibition of indoleacetic acid formation via tryptophan", "negative regulation of indoleacetic acid synthesis via tryptophan", "inhibition of IAA biosynthetic process via tryptophan", "down-regulation of indoleacetic acid anabolism via tryptophan", "negative regulation of indoleacetic acid formation via tryptophan", "down regulation of indoleacetic acid formation via tryptophan", "downregulation of indoleacetic acid synthesis via tryptophan", "negative regulation of IAA biosynthetic process via tryptophan", "down regulation of IAA biosynthetic process via tryptophan", "downregulation of IAA biosynthetic process via tryptophan", "down regulation of indoleacetic acid biosynthetic process via tryptophan", "down-regulation of indoleacetic acid formation via tryptophan", "down-regulation of indoleacetic acid synthesis via tryptophan"], "types": ["T044"], "canonical_name": "negative regulation of indoleacetic acid biosynthetic process via tryptophan", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan. [GOC:TermGenie, PMID:23377040]"}
{"concept_id": "C3546780", "aliases": ["regulation of indoleacetic acid synthesis via tryptophan", "regulation of indoleacetic acid anabolism via tryptophan", "regulation of IAA biosynthetic process via tryptophan", "regulation of indoleacetic acid formation via tryptophan"], "types": ["T044"], "canonical_name": "regulation of indoleacetic acid biosynthetic process via tryptophan", "definition": "Any process that modulates the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan. [GOC:TermGenie, PMID:23377040]"}
{"concept_id": "C3546781", "aliases": ["up regulation of meiotic cell cycle phase transition", "upregulation of meiotic cell cycle phase transition", "up-regulation of meiotic cell cycle phase transition"], "types": ["T043"], "canonical_name": "positive regulation of meiotic cell cycle phase transition", "definition": "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]"}
{"concept_id": "C3546782", "aliases": ["down-regulation of meiotic cell cycle phase transition", "down regulation of meiotic cell cycle phase transition", "downregulation of meiotic cell cycle phase transition"], "types": ["T043"], "canonical_name": "negative regulation of meiotic cell cycle phase transition", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]"}
{"concept_id": "C3546783", "aliases": ["meiotic cell cycle control"], "types": ["T044"], "canonical_name": "regulation of meiotic cell cycle phase transition", "definition": "Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]"}
{"concept_id": "C3546784", "aliases": ["up-regulation of mitotic cell cycle phase transition", "up regulation of mitotic cell cycle phase transition", "upregulation of mitotic cell cycle phase transition"], "types": ["T043"], "canonical_name": "positive regulation of mitotic cell cycle phase transition", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]"}
{"concept_id": "C3546785", "aliases": ["down-regulation of mitotic cell cycle phase transition", "down regulation of mitotic cell cycle phase transition", "downregulation of mitotic cell cycle phase transition"], "types": ["T043"], "canonical_name": "negative regulation of mitotic cell cycle phase transition", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]"}
{"concept_id": "C3546786", "aliases": ["mitotic cell cycle control"], "types": ["T043"], "canonical_name": "regulation of mitotic cell cycle phase transition", "definition": "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]"}
{"concept_id": "C3546787", "aliases": [], "types": ["T043"], "canonical_name": "response to ketamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus. [GOC:TermGenie, PMID:11251190]"}
{"concept_id": "C3546788", "aliases": ["up regulation of protein acetylation", "positive regulation of protein amino acid acetylation", "upregulation of protein acetylation", "up-regulation of protein acetylation", "up regulation of protein amino acid acetylation", "up-regulation of protein amino acid acetylation", "upregulation of protein amino acid acetylation"], "types": ["T044"], "canonical_name": "positive regulation of protein acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of protein acetylation. [GOC:TermGenie, PMID:22117195]"}
{"concept_id": "C3546789", "aliases": ["downregulation of protein amino acid acetylation", "down-regulation of protein amino acid acetylation", "downregulation of protein acetylation", "down regulation of protein amino acid acetylation", "down regulation of protein acetylation", "negative regulation of protein amino acid acetylation", "down-regulation of protein acetylation"], "types": ["T044"], "canonical_name": "negative regulation of protein acetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. [GOC:TermGenie, PMID:22117195]"}
{"concept_id": "C3546790", "aliases": ["regulation of protein amino acid acetylation"], "types": ["T044"], "canonical_name": "regulation of protein acetylation", "definition": "Any process that modulates the frequency, rate or extent of protein acetylation. [GOC:TermGenie, PMID:22117195]"}
{"concept_id": "C3546791", "aliases": [], "types": ["T044"], "canonical_name": "maltose binding", "definition": "Binding to maltose. [GOC:TermGenie, PMID:21566157]"}
{"concept_id": "C3546792", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol phosphate binding", "definition": "Binding to phosphatidylinositol phosphate. [GOC:TermGenie, PMID:23445487]"}
{"concept_id": "C3546793", "aliases": ["upregulation of Kir channel activity", "activation of Kir channel activity", "upregulation of inward rectifier potassium channel activity", "up-regulation of Kir channel activity", "positive regulation of Kir channel activity", "up regulation of Kir channel activity", "up-regulation of inward rectifier potassium channel activity", "up regulation of inward rectifier potassium channel activity"], "types": ["T044"], "canonical_name": "positive regulation of inward rectifier potassium channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of inward rectifier potassium channel activity. [GOC:TermGenie, PMID:23449501]"}
{"concept_id": "C3546794", "aliases": ["regulation of Kir channel activity"], "types": ["T044"], "canonical_name": "regulation of inward rectifier potassium channel activity", "definition": "Any process that modulates the frequency, rate or extent of inward rectifier potassium channel activity. [GOC:TermGenie, PMID:23449501]"}
{"concept_id": "C3546795", "aliases": ["up-regulation of cell cycle checkpoint", "up regulation of cell cycle checkpoint", "upregulation of cell cycle checkpoint"], "types": ["T043"], "canonical_name": "positive regulation of cell cycle checkpoint", "definition": "Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]"}
{"concept_id": "C3546796", "aliases": ["downregulation of cell cycle checkpoint", "down-regulation of cell cycle checkpoint", "down regulation of cell cycle checkpoint"], "types": ["T043"], "canonical_name": "negative regulation of cell cycle checkpoint", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]"}
{"concept_id": "C3546797", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell cycle checkpoint", "definition": "Any process that modulates the frequency, rate or extent of cell cycle checkpoint. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]"}
{"concept_id": "C3546798", "aliases": [], "types": ["T043"], "canonical_name": "glycerate transmembrane transport", "definition": "The process in which glycerate is transported across a membrane. [GOC:TermGenie, pmid:23382251]"}
{"concept_id": "C3546799", "aliases": [], "types": ["T044"], "canonical_name": "glycerate transmembrane transporter activity", "definition": "Enables the transfer of glycerate from one side of a membrane to the other. [GOC:TermGenie, pmid:23382251]"}
{"concept_id": "C3546800", "aliases": [], "types": ["T044"], "canonical_name": "proline binding", "definition": "Binding to proline. [GOC:pm, GOC:TermGenie, PMID:7730362]"}
{"concept_id": "C3546801", "aliases": ["up-regulation of DNA-5-methylcytosine glycosylase activity", "up regulation of DNA-5-methylcytosine glycosylase activity", "upregulation of DNA-5-methylcytosine glycosylase activity"], "types": ["T044"], "canonical_name": "positive regulation of DNA-5-methylcytosine glycosylase activity", "definition": "Any process that activates or increases the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity. [GOC:TermGenie, PMID:23316050]"}
{"concept_id": "C3546802", "aliases": [], "types": ["T044"], "canonical_name": "regulation of DNA-5-methylcytosine glycosylase activity", "definition": "Any process that modulates the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity. [GOC:TermGenie, PMID:23316050]"}
{"concept_id": "C3546803", "aliases": ["up regulation of sister chromatid separation during mitosis", "activation of sister chromatid separation during mitosis", "activation of mitotic sister chromatid resolution", "upregulation of sister chromatid separation during mitosis", "upregulation of mitotic sister chromatid resolution", "up-regulation of mitotic sister chromatid resolution", "positive regulation of mitotic sister chromatid resolution", "up-regulation of sister chromatid separation during mitosis", "up regulation of mitotic sister chromatid separation", "positive regulation of sister chromatid separation during mitosis", "up-regulation of mitotic sister chromatid separation", "upregulation of mitotic sister chromatid separation", "up regulation of mitotic sister chromatid resolution"], "types": ["T043"], "canonical_name": "positive regulation of mitotic sister chromatid separation", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. [GOC:TermGenie, PMID:1846086]"}
{"concept_id": "C3546804", "aliases": ["positive regulation of polynucleotide 3'-phosphohydrolase activity", "up regulation of 2'(3')-polynucleotidase activity", "upregulation of 5'-polynucleotidekinase 3'-phosphatase activity", "upregulation of polynucleotide 3'-phosphatase activity", "up-regulation of polynucleotide 3'-phosphatase activity", "positive regulation of 2'(3')-polynucleotidase activity", "up regulation of deoxyribonucleate 3'-phosphatase activity", "activation of DNA 3'-phosphatase activity", "upregulation of polynucleotide 3'-phosphohydrolase activity", "positive regulation of DNA 3'-phosphatase activity", "up regulation of DNA 3'-phosphatase activity", "up regulation of 5'-polynucleotidekinase 3'-phosphatase activity", "up regulation of polynucleotide 3'-phosphohydrolase activity", "up-regulation of 2'(3')-polynucleotidase activity", "activation of 5'-polynucleotidekinase 3'-phosphatase activity", "up regulation of polynucleotide 3'-phosphatase activity", "upregulation of DNA 3'-phosphatase activity", "up-regulation of deoxyribonucleate 3'-phosphatase activity", "positive regulation of deoxyribonucleate 3'-phosphatase activity", "activation of 2'(3')-polynucleotidase activity", "upregulation of deoxyribonucleate 3'-phosphatase activity", "positive regulation of 5'-polynucleotidekinase 3'-phosphatase activity", "activation of polynucleotide 3'-phosphohydrolase activity", "up-regulation of DNA 3'-phosphatase activity", "up-regulation of polynucleotide 3'-phosphohydrolase activity", "up-regulation of 5'-polynucleotidekinase 3'-phosphatase activity", "upregulation of 2'(3')-polynucleotidase activity", "activation of deoxyribonucleate 3'-phosphatase activity"], "types": ["T044"], "canonical_name": "positive regulation of polynucleotide 3'-phosphatase activity", "definition": "Any process that activates or increases the frequency, rate or extent of polynucleotide 3'-phosphatase activity. [GOC:TermGenie, PMID:23316050]"}
{"concept_id": "C3546805", "aliases": ["regulation of 2'(3')-polynucleotidase activity", "regulation of 5'-polynucleotidekinase 3'-phosphatase activity", "regulation of polynucleotide 3'-phosphohydrolase activity", "regulation of deoxyribonucleate 3'-phosphatase activity", "regulation of DNA 3'-phosphatase activity"], "types": ["T044"], "canonical_name": "regulation of polynucleotide 3'-phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of polynucleotide 3'-phosphatase activity. [GOC:TermGenie, PMID:23316050]"}
{"concept_id": "C3546806", "aliases": ["down-regulation of cellular response to iron ion starvation", "downregulation of cellular response to iron ion starvation", "down regulation of cellular response to iron ion starvation"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to iron ion starvation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to iron ion starvation. [GOC:TermGenie, PMID:23115244]"}
{"concept_id": "C3546807", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to iron ion starvation", "definition": "Any process that modulates the frequency, rate or extent of cellular response to iron ion starvation. [GOC:TermGenie, PMID:23115244]"}
{"concept_id": "C3546808", "aliases": ["ER to chloroplast transport"], "types": ["T043"], "canonical_name": "endoplasmic reticulum to chloroplast transport", "definition": "The directed movement of substances from endoplasmic reticulum to chloroplast. [GOC:TermGenie, PMID:18689504]"}
{"concept_id": "C3546809", "aliases": ["up regulation of cell proliferation involved in outflow tract morphogenesis", "upregulation of cell proliferation involved in outflow tract morphogenesis", "up-regulation of cell proliferation involved in outflow tract morphogenesis"], "types": ["T043"], "canonical_name": "positive regulation of cell proliferation involved in outflow tract morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]"}
{"concept_id": "C3546810", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in outflow tract morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]"}
{"concept_id": "C3546811", "aliases": ["SAM transmembrane transport", "S-adenosylmethionine transmembrane transport"], "types": ["T043"], "canonical_name": "S-adenosyl-L-methionine transmembrane transport", "definition": "The directed movement of S-adenosyl-L-methionine across a membrane. [GOC:TermGenie, PMID:10497160]"}
{"concept_id": "C3546812", "aliases": ["isobutanol anabolism", "isobutanol formation", "isobutanol synthesis", "isobutanol biosynthesis"], "types": ["T044"], "canonical_name": "isobutanol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of isobutanol. [GOC:mengo_curators, GOC:TermGenie, PMID:22224870]"}
{"concept_id": "C3546813", "aliases": ["isobutanol metabolism"], "types": ["T044"], "canonical_name": "isobutanol metabolic process", "definition": "The chemical reactions and pathways involving isobutanol. [GOC:mengo_curators, GOC:TermGenie, PMID:22224870]"}
{"concept_id": "C3546814", "aliases": ["up-regulation of cutin synthesis", "positive regulation of cutin biosynthesis", "up-regulation of cutin anabolism", "upregulation of cutin anabolism", "up regulation of cutin synthesis", "upregulation of cutin synthesis", "positive regulation of cutin anabolism", "activation of cutin biosynthesis", "up regulation of cutin formation", "upregulation of cutin formation", "up regulation of cutin biosynthetic process", "activation of cutin formation", "activation of cutin anabolism", "positive regulation of cutin synthesis", "upregulation of cutin biosynthesis", "up-regulation of cutin biosynthetic process", "activation of cutin synthesis", "up regulation of cutin biosynthesis", "up-regulation of cutin formation", "up regulation of cutin anabolism", "up-regulation of cutin biosynthesis", "upregulation of cutin biosynthetic process", "positive regulation of cutin formation"], "types": ["T044"], "canonical_name": "positive regulation of cutin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of cutin biosynthetic process. [GOC:tb, GOC:TermGenie, PMID:23243127]"}
{"concept_id": "C3546815", "aliases": ["down regulation of cutin synthesis", "down regulation of cutin biosynthetic process", "down regulation of cutin biosynthesis", "negative regulation of cutin biosynthesis", "downregulation of cutin synthesis", "negative regulation of cutin synthesis", "downregulation of cutin biosynthetic process", "down-regulation of cutin biosynthesis", "downregulation of cutin anabolism", "inhibition of cutin formation", "downregulation of cutin biosynthesis", "down regulation of cutin anabolism", "down-regulation of cutin anabolism", "inhibition of cutin synthesis", "inhibition of cutin anabolism", "inhibition of cutin biosynthesis", "down regulation of cutin formation", "down-regulation of cutin biosynthetic process", "downregulation of cutin formation", "down-regulation of cutin synthesis", "down-regulation of cutin formation", "negative regulation of cutin anabolism", "negative regulation of cutin formation"], "types": ["T044"], "canonical_name": "negative regulation of cutin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cutin biosynthetic process. [GOC:tb, GOC:TermGenie, PMID:23243127]"}
{"concept_id": "C3546816", "aliases": ["regulation of cutin synthesis", "regulation of cutin biosynthesis", "regulation of cutin anabolism", "regulation of cutin formation"], "types": ["T044"], "canonical_name": "regulation of cutin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of cutin biosynthetic process. [GOC:tb, GOC:TermGenie, PMID:23243127]"}
{"concept_id": "C3546817", "aliases": ["upregulation of retrograde dense core granule transport", "up regulation of retrograde dense core granule transport", "up-regulation of retrograde dense core granule transport"], "types": ["T043"], "canonical_name": "positive regulation of retrograde dense core granule transport", "definition": "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport. [GOC:kmv, GOC:TermGenie, PMID:23358451]"}
{"concept_id": "C3546818", "aliases": ["downregulation of retrograde dense core granule transport", "down regulation of retrograde dense core granule transport", "down-regulation of retrograde dense core granule transport"], "types": ["T043"], "canonical_name": "negative regulation of retrograde dense core granule transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport. [GOC:kmv, GOC:TermGenie, PMID:23358451]"}
{"concept_id": "C3546819", "aliases": [], "types": ["T043"], "canonical_name": "regulation of retrograde dense core granule transport", "definition": "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport. [GOC:kmv, GOC:TermGenie, PMID:23358451]"}
{"concept_id": "C3546820", "aliases": ["up regulation of anterograde dense core granule transport", "upregulation of anterograde dense core granule transport", "up-regulation of anterograde dense core granule transport"], "types": ["T043"], "canonical_name": "positive regulation of anterograde dense core granule transport", "definition": "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport. [GOC:kmv, GOC:TermGenie, PMID:23358451]"}
{"concept_id": "C3546821", "aliases": ["down regulation of anterograde dense core granule transport", "downregulation of anterograde dense core granule transport", "down-regulation of anterograde dense core granule transport"], "types": ["T043"], "canonical_name": "negative regulation of anterograde dense core granule transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport. [GOC:kmv, GOC:TermGenie, PMID:23358451]"}
{"concept_id": "C3546822", "aliases": [], "types": ["T043"], "canonical_name": "regulation of anterograde dense core granule transport", "definition": "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport. [GOC:kmv, GOC:TermGenie, PMID:23358451]"}
{"concept_id": "C3546823", "aliases": ["dense core vesicle transport"], "types": ["T043"], "canonical_name": "dense core granule transport", "definition": "The directed movement a dense core granule within a cell. [GOC:kmv, GOC:TermGenie, PMID:23358451]"}
{"concept_id": "C3546824", "aliases": ["5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthesis", "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate anabolism", "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate synthesis", "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate formation"], "types": ["T044"], "canonical_name": "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate. [GOC:TermGenie, pmid:22027823]"}
{"concept_id": "C3546825", "aliases": ["5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate degradation", "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate breakdown", "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolism"], "types": ["T044"], "canonical_name": "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate. [GOC:TermGenie, pmid:22027823]"}
{"concept_id": "C3546826", "aliases": ["5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolism"], "types": ["T044"], "canonical_name": "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process", "definition": "The chemical reactions and pathways involving 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate. [GOC:TermGenie, pmid:22027823]"}
{"concept_id": "C3546827", "aliases": ["miltiradiene biosynthesis", "miltiradiene synthesis", "miltiradiene anabolism", "miltiradiene formation"], "types": ["T044"], "canonical_name": "miltiradiene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of miltiradiene. [GOC:TermGenie, pmid:22027823]"}
{"concept_id": "C3546828", "aliases": ["miltiradiene breakdown", "miltiradiene catabolism", "miltiradiene degradation"], "types": ["T044"], "canonical_name": "miltiradiene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of miltiradiene. [GOC:TermGenie, pmid:22027823]"}
{"concept_id": "C3546829", "aliases": ["miltiradiene metabolism"], "types": ["T044"], "canonical_name": "miltiradiene metabolic process", "definition": "The chemical reactions and pathways involving miltiradiene. [GOC:TermGenie, pmid:22027823]"}
{"concept_id": "C3546830", "aliases": ["(+)-epi-alpha-bisabolol biosynthesis", "(+)-epi-alpha-bisabolol formation", "(+)-epi-alpha-bisabolol synthesis", "(+)-epi-alpha-bisabolol anabolism"], "types": ["T044"], "canonical_name": "(+)-epi-alpha-bisabolol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (+)-epi-alpha-bisabolol. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546831", "aliases": ["(+)-epi-alpha-bisabolol degradation", "(+)-epi-alpha-bisabolol catabolism", "(+)-epi-alpha-bisabolol breakdown"], "types": ["T044"], "canonical_name": "(+)-epi-alpha-bisabolol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (+)-epi-alpha-bisabolol. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546832", "aliases": ["(+)-epi-alpha-bisabolol metabolism"], "types": ["T044"], "canonical_name": "(+)-epi-alpha-bisabolol metabolic process", "definition": "The chemical reactions and pathways involving (+)-epi-alpha-bisabolol. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546833", "aliases": ["(-)-exo-alpha-bergamotene biosynthesis", "(-)-exo-alpha-bergamotene formation", "(-)-exo-alpha-bergamotene synthesis", "(-)-exo-alpha-bergamotene anabolism"], "types": ["T044"], "canonical_name": "(-)-exo-alpha-bergamotene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (-)-exo-alpha-bergamotene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546834", "aliases": ["(-)-exo-alpha-bergamotene catabolism", "(-)-exo-alpha-bergamotene degradation", "(-)-exo-alpha-bergamotene breakdown"], "types": ["T044"], "canonical_name": "(-)-exo-alpha-bergamotene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (-)-exo-alpha-bergamotene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546835", "aliases": ["(-)-exo-alpha-bergamotene metabolism"], "types": ["T044"], "canonical_name": "(-)-exo-alpha-bergamotene metabolic process", "definition": "The chemical reactions and pathways involving (-)-exo-alpha-bergamotene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546836", "aliases": ["beta-caryophyllene formation", "beta-caryophyllene biosynthesis", "beta-caryophyllene synthesis", "beta-caryophyllene anabolism"], "types": ["T044"], "canonical_name": "beta-caryophyllene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-caryophyllene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546837", "aliases": ["beta-caryophyllene degradation", "beta-caryophyllene breakdown", "beta-caryophyllene catabolism"], "types": ["T044"], "canonical_name": "beta-caryophyllene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of beta-caryophyllene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546838", "aliases": ["beta-caryophyllene metabolism"], "types": ["T044"], "canonical_name": "beta-caryophyllene metabolic process", "definition": "The chemical reactions and pathways involving beta-caryophyllene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546839", "aliases": ["bicyclogermacrene formation", "bicyclogermacrene anabolism", "bicyclogermacrene synthesis", "bicyclogermacrene biosynthesis"], "types": ["T044"], "canonical_name": "bicyclogermacrene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of bicyclogermacrene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546840", "aliases": ["bicyclogermacrene breakdown", "bicyclogermacrene catabolism", "bicyclogermacrene degradation"], "types": ["T044"], "canonical_name": "bicyclogermacrene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of bicyclogermacrene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546841", "aliases": ["bicyclogermacrene metabolism"], "types": ["T044"], "canonical_name": "bicyclogermacrene metabolic process", "definition": "The chemical reactions and pathways involving bicyclogermacrene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546842", "aliases": ["alpha-copaene formation", "alpha-copaene biosynthesis", "alpha-copaene anabolism", "alpha-copaene synthesis"], "types": ["T044"], "canonical_name": "alpha-copaene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alpha-copaene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546843", "aliases": ["alpha-copaene degradation", "alpha-copaene catabolism", "alpha-copaene breakdown"], "types": ["T044"], "canonical_name": "alpha-copaene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alpha-copaene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546844", "aliases": ["alpha-copaene metabolism"], "types": ["T044"], "canonical_name": "alpha-copaene metabolic process", "definition": "The chemical reactions and pathways involving alpha-copaene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546845", "aliases": ["cadinene synthesis", "cadinene anabolism", "cadinene biosynthesis", "cadinene formation"], "types": ["T044"], "canonical_name": "cadinene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cadinene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546846", "aliases": ["cadinene catabolism", "cadinene breakdown", "cadinene degradation"], "types": ["T044"], "canonical_name": "cadinene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cadinene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546847", "aliases": ["cadinene metabolism"], "types": ["T044"], "canonical_name": "cadinene metabolic process", "definition": "The chemical reactions and pathways involving cadinene. [GOC:TermGenie, pmid:22867794]"}
{"concept_id": "C3546848", "aliases": ["upregulation of sclerotium development", "up-regulation of sclerotium development", "up regulation of sclerotium development"], "types": ["T039"], "canonical_name": "positive regulation of sclerotium development", "definition": "Any process that activates or increases the frequency, rate or extent of sclerotium development. [GOC:di, GOC:TermGenie, PMID:21148914]"}
{"concept_id": "C3546849", "aliases": ["downregulation of sclerotium development", "down regulation of sclerotium development", "down-regulation of sclerotium development"], "types": ["T039"], "canonical_name": "negative regulation of sclerotium development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sclerotium development. [GOC:di, GOC:TermGenie, PMID:21148914]"}
{"concept_id": "C3546850", "aliases": [], "types": ["T039"], "canonical_name": "regulation of sclerotium development", "definition": "Any process that modulates the frequency, rate or extent of sclerotium development. [GOC:di, GOC:TermGenie, PMID:21148914]"}
{"concept_id": "C3546851", "aliases": ["CTD domain phosphorylation of RNA polymerase II involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex"], "types": ["T045"], "canonical_name": "phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex", "definition": "Any phosphorylation of RNA polymerase II C-terminal domain that is involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex. [GOC:TermGenie, PMID:10594013]"}
{"concept_id": "C3546852", "aliases": ["up-regulation of exoribonuclease activity", "up regulation of exoribonuclease activity", "upregulation of exoribonuclease activity"], "types": ["T045"], "canonical_name": "positive regulation of exoribonuclease activity", "definition": "Any process that activates or increases the frequency, rate or extent of exoribonuclease activity. [GOC:TermGenie, PMID:22570495]"}
{"concept_id": "C3546853", "aliases": ["downregulation of exoribonuclease activity", "down-regulation of exoribonuclease activity", "down regulation of exoribonuclease activity"], "types": ["T045"], "canonical_name": "negative regulation of exoribonuclease activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of exoribonuclease activity. [GOC:TermGenie, PMID:22570495]"}
{"concept_id": "C3546854", "aliases": [], "types": ["T045"], "canonical_name": "regulation of exoribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of exoribonuclease activity. [GOC:TermGenie, PMID:22570495]"}
{"concept_id": "C3546856", "aliases": ["up regulation of capsule organization", "positive regulation of capsule organisation", "upregulation of capsule organisation", "up-regulation of capsule organization", "up-regulation of capsule organisation", "upregulation of capsule organization", "up regulation of capsule organisation"], "types": ["T043"], "canonical_name": "positive regulation of capsule organization", "definition": "Any process that activates or increases the frequency, rate or extent of capsule organization. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3546857", "aliases": ["negative regulation of capsule organisation", "down-regulation of capsule organisation", "down regulation of capsule organisation", "downregulation of capsule organisation", "down regulation of capsule organization", "downregulation of capsule organization", "down-regulation of capsule organization"], "types": ["T043"], "canonical_name": "negative regulation of capsule organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of capsule organization. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3546858", "aliases": ["regulation of capsule organisation"], "types": ["T043"], "canonical_name": "regulation of capsule organization", "definition": "Any process that modulates the frequency, rate or extent of capsule organization. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3546860", "aliases": ["adenosine 5'-(hexahydrogen pentaphosphate) degradation", "adenosine 5'-(hexahydrogen pentaphosphate) breakdown", "adenosine 5'-(hexahydrogen pentaphosphate) catabolism"], "types": ["T044"], "canonical_name": "adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate). [GOC:TermGenie, PMID:10090752]"}
{"concept_id": "C3546861", "aliases": ["adenosine 5'-(hexahydrogen pentaphosphate) metabolism"], "types": ["T044"], "canonical_name": "adenosine 5'-(hexahydrogen pentaphosphate) metabolic process", "definition": "The chemical reactions and pathways involving adenosine 5'-(hexahydrogen pentaphosphate). [GOC:TermGenie, PMID:10090752]"}
{"concept_id": "C3546862", "aliases": ["diadenosyl hexaphosphate breakdown", "diadenosyl hexaphosphate catabolism", "diadenosyl hexaphosphate catabolic process", "diadenosine hexaphosphate catabolism", "diadenosyl hexaphosphate degradation"], "types": ["T044"], "canonical_name": "diadenosine hexaphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate. [GOC:TermGenie, PMID:10090752]"}
{"concept_id": "C3546863", "aliases": ["diadenosine hexaphosphate metabolism", "diadenosyl hexaphosphate metabolic process", "diadenosyl hexaphosphate metabolism"], "types": ["T044"], "canonical_name": "diadenosine hexaphosphate metabolic process", "definition": "The chemical reactions and pathways involving diadenosine hexaphosphate. [GOC:TermGenie, PMID:10090752]"}
{"concept_id": "C3546864", "aliases": ["diadenosyl pentaphosphate catabolism", "diadenosyl pentaphosphate catabolic process", "diadenosyl pentaphosphate degradation", "diadenosine pentaphosphate catabolism", "diadenosyl pentaphosphate breakdown"], "types": ["T044"], "canonical_name": "diadenosine pentaphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate. [GOC:TermGenie, PMID:10090752]"}
{"concept_id": "C3546865", "aliases": ["diadenosyl pentaphosphate metabolism", "diadenosyl pentaphosphate metabolic process", "diadenosine pentaphosphate metabolism"], "types": ["T044"], "canonical_name": "diadenosine pentaphosphate metabolic process", "definition": "The chemical reactions and pathways involving diadenosine pentaphosphate. [GOC:TermGenie, PMID:10090752]"}
{"concept_id": "C3546866", "aliases": [], "types": ["T043"], "canonical_name": "response to tamsulosin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tamsulosin stimulus. [GOC:TermGenie]"}
{"concept_id": "C3546867", "aliases": ["tyrocidine synthesis", "tyrocidine formation", "tyrocidine biosynthesis", "tyrocidine anabolism"], "types": ["T044"], "canonical_name": "tyrocidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tyrocidine. [GOC:TermGenie, GOC:yaf, PMID:9352938, UniPathway:UPA00180]"}
{"concept_id": "C3546868", "aliases": ["tyrocidine breakdown", "tyrocidine catabolism", "tyrocidine degradation"], "types": ["T044"], "canonical_name": "tyrocidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tyrocidine. [GOC:TermGenie, GOC:yaf, PMID:9352938]"}
{"concept_id": "C3546869", "aliases": ["tyrocidine metabolism"], "types": ["T044"], "canonical_name": "tyrocidine metabolic process", "definition": "The chemical reactions and pathways involving tyrocidine. [GOC:TermGenie, GOC:yaf, PMID:9352938]"}
{"concept_id": "C3546870", "aliases": ["regulation of protein localisation to cell division site involved in cytokinesis"], "types": ["T039"], "canonical_name": "regulation of protein localization to cell division site involved in cytokinesis", "definition": "Any regulation of protein localization to cell division site that is involved in cytokinesis. [GOC:dph, GOC:TermGenie, PMID:22573892]"}
{"concept_id": "C3546871", "aliases": ["regulation of protein localisation to cell division site"], "types": ["T039"], "canonical_name": "regulation of protein localization to cell division site", "definition": "Any process that modulates the frequency, rate or extent of protein localization to cell division site. [GOC:dph, GOC:TermGenie, PMID:22573892]"}
{"concept_id": "C3546872", "aliases": ["up-regulation of relaxation of cardiac muscle", "upregulation of relaxation of cardiac muscle", "up regulation of relaxation of cardiac muscle"], "types": ["T039"], "canonical_name": "positive regulation of relaxation of cardiac muscle", "definition": "Any process that activates or increases the frequency, rate or extent of relaxation of cardiac muscle. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]"}
{"concept_id": "C3546873", "aliases": ["down regulation of relaxation of cardiac muscle", "downregulation of relaxation of cardiac muscle", "down-regulation of relaxation of cardiac muscle"], "types": ["T039"], "canonical_name": "negative regulation of relaxation of cardiac muscle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]"}
{"concept_id": "C3546874", "aliases": [], "types": ["T042"], "canonical_name": "regulation of relaxation of cardiac muscle", "definition": "Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]"}
{"concept_id": "C3546875", "aliases": ["up-regulation of ATP phosphohydrolase (Ca2+-transporting)", "upregulation of Ca2+-pumping ATPase activity", "positive regulation of Ca2+-pumping ATPase activity", "up-regulation of calcium transporting ATPase activity", "positive regulation of Ca2+-transporting ATPase activity", "up-regulation of calcium-transporting ATPase activity", "up-regulation of Ca(2+)-transporting ATPase activity", "positive regulation of ATP phosphohydrolase (Ca2+-transporting)", "up regulation of Ca2+-pumping ATPase activity", "activation of Ca2+-transporting ATPase activity", "positive regulation of calcium-transporting ATPase activity", "positive regulation of calcium transporting ATPase activity", "activation of Ca2+-pumping ATPase activity", "up-regulation of Ca2+-transporting ATPase activity", "up regulation of Ca(2+)-transporting ATPase activity", "upregulation of calcium transporting ATPase activity", "upregulation of ATP phosphohydrolase (Ca2+-transporting)", "up-regulation of Ca2+-pumping ATPase activity", "up regulation of ATP phosphohydrolase (Ca2+-transporting)", "positive regulation of Ca(2+)-transporting ATPase activity", "activation of calcium-transporting ATPase activity", "up regulation of Ca2+-transporting ATPase activity", "activation of Ca(2+)-transporting ATPase activity", "activation of ATP phosphohydrolase (Ca2+-transporting)", "upregulation of Ca2+-transporting ATPase activity", "upregulation of Ca(2+)-transporting ATPase activity", "activation of calcium transporting ATPase activity", "up regulation of calcium-transporting ATPase activity", "up regulation of calcium transporting ATPase activity", "upregulation of calcium-transporting ATPase activity"], "types": ["T044"], "canonical_name": "positive regulation of ATPase-coupled calcium transmembrane transporter activity", "definition": "Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]"}
{"concept_id": "C3546876", "aliases": ["inhibition of Ca(2+)-transporting ATPase activity", "down-regulation of Ca2+-transporting ATPase activity", "negative regulation of Ca2+-pumping ATPase activity", "down regulation of ATP phosphohydrolase (Ca2+-transporting)", "downregulation of Ca2+-transporting ATPase activity", "negative regulation of Ca(2+)-transporting ATPase activity", "downregulation of Ca(2+)-transporting ATPase activity", "down-regulation of ATP phosphohydrolase (Ca2+-transporting)", "down regulation of calcium transporting ATPase activity", "negative regulation of ATP phosphohydrolase (Ca2+-transporting)", "inhibition of Ca2+-pumping ATPase activity", "down regulation of calcium-transporting ATPase activity", "down-regulation of calcium-transporting ATPase activity", "down-regulation of calcium transporting ATPase activity", "downregulation of Ca2+-pumping ATPase activity", "downregulation of calcium transporting ATPase activity", "down regulation of Ca(2+)-transporting ATPase activity", "down regulation of Ca2+-transporting ATPase activity", "inhibition of calcium-transporting ATPase activity", "negative regulation of calcium-transporting ATPase activity", "inhibition of calcium transporting ATPase activity", "inhibition of ATP phosphohydrolase (Ca2+-transporting)", "negative regulation of Ca2+-transporting ATPase activity", "down-regulation of Ca(2+)-transporting ATPase activity", "downregulation of calcium-transporting ATPase activity", "downregulation of ATP phosphohydrolase (Ca2+-transporting)", "negative regulation of calcium transporting ATPase activity", "down-regulation of Ca2+-pumping ATPase activity", "down regulation of Ca2+-pumping ATPase activity", "inhibition of Ca2+-transporting ATPase activity"], "types": ["T044"], "canonical_name": "negative regulation of ATPase-coupled calcium transmembrane transporter activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]"}
{"concept_id": "C3546877", "aliases": ["regulation of Ca2+-pumping ATPase activity", "regulation of calcium-transporting ATPase activity", "regulation of Ca2+-transporting ATPase activity", "regulation of Ca(2+)-transporting ATPase activity", "regulation of ATP phosphohydrolase (Ca2+-transporting)", "regulation of calcium transporting ATPase activity"], "types": ["T044"], "canonical_name": "regulation of ATPase-coupled calcium transmembrane transporter activity", "definition": "Any process that modulates the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]"}
{"concept_id": "C3546878", "aliases": ["up regulation of cell septum assembly", "up-regulation of cell septum assembly", "upregulation of cell septum assembly"], "types": ["T043"], "canonical_name": "positive regulation of cell septum assembly", "definition": "Any process that activates or increases the frequency, rate or extent of cell septum assembly. [GOC:TermGenie]"}
{"concept_id": "C3546879", "aliases": ["down-regulation of cell septum assembly", "downregulation of cell septum assembly", "down regulation of cell septum assembly"], "types": ["T043"], "canonical_name": "negative regulation of cell septum assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell septum assembly. [GOC:TermGenie]"}
{"concept_id": "C3546880", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell septum assembly", "definition": "Any process that modulates the frequency, rate or extent of cell septum assembly. [GOC:TermGenie]"}
{"concept_id": "C3546881", "aliases": ["up regulation of cell junction assembly", "upregulation of cell junction assembly", "up-regulation of cell junction assembly"], "types": ["T043"], "canonical_name": "positive regulation of cell junction assembly", "definition": "Any process that activates or increases the frequency, rate or extent of cell junction assembly. [GOC:TermGenie]"}
{"concept_id": "C3546882", "aliases": ["down-regulation of cell junction assembly", "downregulation of cell junction assembly", "down regulation of cell junction assembly"], "types": ["T043"], "canonical_name": "negative regulation of cell junction assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. [GOC:TermGenie]"}
{"concept_id": "C3546883", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell junction assembly", "definition": "Any process that modulates the frequency, rate or extent of cell junction assembly. [GOC:TermGenie]"}
{"concept_id": "C3546884", "aliases": ["2-hydroxybenzoyl-CoA synthesis", "2-hydroxybenzoyl-CoA biosynthesis", "2-hydroxybenzoyl-CoA anabolism", "2-hydroxybenzoyl-CoA formation"], "types": ["T044"], "canonical_name": "2-hydroxybenzoyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 2-hydroxybenzoyl-CoA. [GOC:TermGenie, pmid:19757094]"}
{"concept_id": "C3546885", "aliases": ["2-hydroxybenzoyl-CoA catabolism", "2-hydroxybenzoyl-CoA breakdown", "2-hydroxybenzoyl-CoA degradation"], "types": ["T044"], "canonical_name": "2-hydroxybenzoyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-hydroxybenzoyl-CoA. [GOC:TermGenie, pmid:19757094]"}
{"concept_id": "C3546886", "aliases": ["2-hydroxybenzoyl-CoA metabolism"], "types": ["T044"], "canonical_name": "2-hydroxybenzoyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving 2-hydroxybenzoyl-CoA. [GOC:TermGenie, pmid:19757094]"}
{"concept_id": "C3546887", "aliases": ["4-hydroxycoumarin anabolism", "4-hydroxycoumarin formation", "4-hydroxycoumarin biosynthesis", "4-hydroxycoumarin synthesis"], "types": ["T044"], "canonical_name": "4-hydroxycoumarin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 4-hydroxycoumarin. [GOC:TermGenie, pmid:19757094]"}
{"concept_id": "C3546888", "aliases": ["4-hydroxycoumarin breakdown", "4-hydroxycoumarin catabolism", "4-hydroxycoumarin degradation"], "types": ["T044"], "canonical_name": "4-hydroxycoumarin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 4-hydroxycoumarin. [GOC:TermGenie, pmid:19757094]"}
{"concept_id": "C3546889", "aliases": ["4-hydroxycoumarin metabolism"], "types": ["T044"], "canonical_name": "4-hydroxycoumarin metabolic process", "definition": "The chemical reactions and pathways involving 4-hydroxycoumarin. [GOC:TermGenie, pmid:19757094]"}
{"concept_id": "C3546890", "aliases": ["upregulation of protein polymer catabolic process", "up regulation of protein polymer breakdown", "activation of protein polymer catabolism", "activation of protein polymer catabolic process", "up regulation of protein polymer catabolic process", "positive regulation of protein polymer breakdown", "upregulation of protein polymer catabolism", "up-regulation of protein polymer degradation", "up regulation of protein depolymerization", "upregulation of protein depolymerization", "upregulation of protein polymer breakdown", "up regulation of protein polymer degradation", "activation of protein polymer degradation", "positive regulation of protein polymer degradation", "activation of protein polymer breakdown", "up-regulation of protein polymer catabolism", "up-regulation of protein polymer catabolic process", "positive regulation of protein polymer catabolism", "up-regulation of protein polymer breakdown", "up-regulation of protein depolymerization", "positive regulation of protein polymer catabolic process", "upregulation of protein polymer degradation", "up regulation of protein polymer catabolism"], "types": ["T044"], "canonical_name": "positive regulation of protein depolymerization", "definition": "Any process that activates or increases the frequency, rate or extent of protein depolymerization. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]"}
{"concept_id": "C3546891", "aliases": ["negative regulation of protein polymer catabolism", "down-regulation of protein polymer catabolic process", "inhibition of protein polymer catabolic process", "downregulation of protein polymer degradation", "downregulation of protein polymer catabolic process", "down regulation of protein polymer catabolic process", "inhibition of protein polymer breakdown", "down regulation of protein depolymerization", "downregulation of protein polymer catabolism", "down-regulation of protein depolymerization", "down-regulation of protein polymer degradation", "down regulation of protein polymer catabolism", "down-regulation of protein polymer catabolism", "negative regulation of protein polymer degradation", "inhibition of protein polymer degradation", "down regulation of protein polymer breakdown", "downregulation of protein depolymerization", "negative regulation of protein polymer breakdown", "negative regulation of protein polymer catabolic process", "inhibition of protein polymer catabolism", "downregulation of protein polymer breakdown", "down regulation of protein polymer degradation", "down-regulation of protein polymer breakdown"], "types": ["T044"], "canonical_name": "negative regulation of protein depolymerization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]"}
{"concept_id": "C3546892", "aliases": ["regulation of protein polymer degradation", "regulation of protein polymer catabolism", "regulation of protein polymer catabolic process", "regulation of protein polymer breakdown"], "types": ["T044"], "canonical_name": "regulation of protein depolymerization", "definition": "Any process that modulates the frequency, rate or extent of protein depolymerization. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]"}
{"concept_id": "C3546893", "aliases": ["up-regulation of calcium ion binding", "up regulation of calcium ion binding", "upregulation of calcium ion binding"], "types": ["T044"], "canonical_name": "positive regulation of calcium ion binding", "definition": "Any process that activates or increases the frequency, rate or extent of calcium ion binding. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]"}
{"concept_id": "C3546894", "aliases": ["down-regulation of calcium ion binding", "downregulation of calcium ion binding", "down regulation of calcium ion binding"], "types": ["T044"], "canonical_name": "negative regulation of calcium ion binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]"}
{"concept_id": "C3546895", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcium ion binding", "definition": "Any process that modulates the frequency, rate or extent of calcium ion binding. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]"}
{"concept_id": "C3546896", "aliases": ["activation of posttranslational protein modification", "up regulation of posttranslational protein modification", "up-regulation of PTM", "activation of posttranslational modification", "up regulation of posttranslational modification", "positive regulation of post-translational modification", "up-regulation of posttranslational amino acid modification", "up regulation of PTM", "upregulation of PTM", "activation of posttranslational amino acid modification", "activation of post-translational modification", "up regulation of post-translational protein modification", "positive regulation of post-translational amino acid modification", "activation of post-translational amino acid modification", "positive regulation of PTM", "positive regulation of posttranslational protein modification", "up regulation of post-translational modification", "upregulation of post-translational protein modification", "up regulation of post-translational amino acid modification", "positive regulation of posttranslational modification", "upregulation of posttranslational modification", "upregulation of post-translational amino acid modification", "up regulation of posttranslational amino acid modification", "positive regulation of posttranslational amino acid modification", "upregulation of posttranslational amino acid modification", "up-regulation of post-translational protein modification", "upregulation of posttranslational protein modification", "up-regulation of post-translational amino acid modification", "upregulation of post-translational modification", "up-regulation of posttranslational protein modification", "activation of PTM", "up-regulation of posttranslational modification", "up-regulation of post-translational modification"], "types": ["T044"], "canonical_name": "positive regulation of post-translational protein modification", "definition": "Any process that activates or increases the frequency, rate or extent of post-translational protein modification. [GOC:TermGenie, GOC:yaf, PMID:21209915]"}
{"concept_id": "C3546897", "aliases": ["inhibition of post-translational modification", "down regulation of post-translational protein modification", "negative regulation of post-translational modification", "down-regulation of posttranslational amino acid modification", "downregulation of post-translational protein modification", "down regulation of post-translational modification", "inhibition of post-translational amino acid modification", "down regulation of posttranslational modification", "down-regulation of posttranslational protein modification", "down regulation of PTM", "down regulation of post-translational amino acid modification", "inhibition of posttranslational protein modification", "down-regulation of post-translational modification", "downregulation of posttranslational protein modification", "downregulation of posttranslational modification", "negative regulation of posttranslational protein modification", "inhibition of posttranslational amino acid modification", "downregulation of post-translational amino acid modification", "negative regulation of posttranslational modification", "negative regulation of PTM", "down-regulation of PTM", "downregulation of PTM", "down-regulation of posttranslational modification", "down regulation of posttranslational protein modification", "negative regulation of post-translational amino acid modification", "down-regulation of post-translational protein modification", "down regulation of posttranslational amino acid modification", "negative regulation of posttranslational amino acid modification", "inhibition of PTM", "inhibition of posttranslational modification", "downregulation of post-translational modification", "down-regulation of post-translational amino acid modification", "downregulation of posttranslational amino acid modification"], "types": ["T044"], "canonical_name": "negative regulation of post-translational protein modification", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification. [GOC:TermGenie, GOC:yaf, PMID:21209915]"}
{"concept_id": "C3546898", "aliases": ["regulation of posttranslational protein modification", "regulation of post-translational modification", "regulation of PTM", "regulation of posttranslational modification", "regulation of posttranslational amino acid modification", "regulation of post-translational amino acid modification"], "types": ["T044"], "canonical_name": "regulation of post-translational protein modification", "definition": "Any process that modulates the frequency, rate or extent of post-translational protein modification. [GOC:TermGenie, GOC:yaf, PMID:21209915]"}
{"concept_id": "C3546899", "aliases": ["ecgonone methyl ester anabolism", "ecgonone methyl ester biosynthesis", "ecgonone methyl ester formation", "ecgonone methyl ester synthesis"], "types": ["T044"], "canonical_name": "ecgonone methyl ester biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ecgonone methyl ester. [GOC:TermGenie, PMID:22665766]"}
{"concept_id": "C3546900", "aliases": ["ecgonone methyl ester degradation", "ecgonone methyl ester breakdown", "ecgonone methyl ester catabolism"], "types": ["T044"], "canonical_name": "ecgonone methyl ester catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ecgonone methyl ester. [GOC:TermGenie, PMID:22665766]"}
{"concept_id": "C3546901", "aliases": ["ecgonone methyl ester metabolism"], "types": ["T044"], "canonical_name": "ecgonone methyl ester metabolic process", "definition": "The chemical reactions and pathways involving ecgonone methyl ester. [GOC:TermGenie, PMID:22665766]"}
{"concept_id": "C3546902", "aliases": ["ecgonine methyl ester anabolism", "ecgonine methyl ester formation", "ecgonine methyl ester synthesis", "ecgonine methyl ester biosynthesis"], "types": ["T044"], "canonical_name": "ecgonine methyl ester biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ecgonine methyl ester. [GOC:TermGenie, PMID:22665766]"}
{"concept_id": "C3546903", "aliases": ["ecgonine methyl ester degradation", "ecgonine methyl ester catabolism", "ecgonine methyl ester breakdown"], "types": ["T044"], "canonical_name": "ecgonine methyl ester catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ecgonine methyl ester. [GOC:TermGenie, PMID:22665766]"}
{"concept_id": "C3546904", "aliases": ["ecgonine methyl ester metabolism"], "types": ["T044"], "canonical_name": "ecgonine methyl ester metabolic process", "definition": "The chemical reactions and pathways involving ecgonine methyl ester. [GOC:TermGenie, PMID:22665766]"}
{"concept_id": "C3546905", "aliases": ["capsorubin anabolism", "capsorubin formation", "capsorubin synthesis", "capsorubin biosynthesis"], "types": ["T044"], "canonical_name": "capsorubin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of capsorubin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]"}
{"concept_id": "C3546906", "aliases": ["capsorubin breakdown", "capsorubin degradation", "capsorubin catabolism"], "types": ["T044"], "canonical_name": "capsorubin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of capsorubin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]"}
{"concept_id": "C3546907", "aliases": ["capsorubin metabolism"], "types": ["T044"], "canonical_name": "capsorubin metabolic process", "definition": "The chemical reactions and pathways involving capsorubin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]"}
{"concept_id": "C3546908", "aliases": ["upregulation of muscle tissue development", "up regulation of muscle tissue development", "up-regulation of muscle tissue development"], "types": ["T039"], "canonical_name": "positive regulation of muscle tissue development", "definition": "Any process that activates or increases the frequency, rate or extent of muscle tissue development. [GOC:TermGenie, GOC:yaf, PMID:23150719]"}
{"concept_id": "C3546909", "aliases": ["downregulation of muscle tissue development", "down regulation of muscle tissue development", "down-regulation of muscle tissue development"], "types": ["T039"], "canonical_name": "negative regulation of muscle tissue development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. [GOC:TermGenie, GOC:yaf, PMID:23150719]"}
{"concept_id": "C3546910", "aliases": [], "types": ["T039"], "canonical_name": "regulation of muscle tissue development", "definition": "Any process that modulates the frequency, rate or extent of muscle tissue development. [GOC:TermGenie, GOC:yaf, PMID:23150719]"}
{"concept_id": "C3546911", "aliases": ["up regulation of mtDNA metabolism", "upregulation of mtDNA metabolism", "activation of mtDNA metabolism", "up-regulation of mitochondrial DNA metabolic process", "activation of mtDNA metabolic process", "positive regulation of mtDNA metabolism", "up-regulation of mitochondrial DNA metabolism", "up-regulation of mtDNA metabolic process", "up-regulation of mtDNA metabolism", "up regulation of mitochondrial DNA metabolism", "upregulation of mitochondrial DNA metabolism", "upregulation of mitochondrial DNA metabolic process", "up regulation of mitochondrial DNA metabolic process", "positive regulation of mitochondrial DNA metabolism", "activation of mitochondrial DNA metabolism", "up regulation of mtDNA metabolic process", "upregulation of mtDNA metabolic process", "positive regulation of mtDNA metabolic process"], "types": ["T045"], "canonical_name": "positive regulation of mitochondrial DNA metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process. [GOC:TermGenie, GOC:yaf, PMID:23150719]"}
{"concept_id": "C3546912", "aliases": ["down regulation of mitochondrial DNA metabolic process", "down regulation of mtDNA metabolism", "negative regulation of mitochondrial DNA metabolism", "negative regulation of mtDNA metabolic process", "inhibition of mitochondrial DNA metabolism", "down-regulation of mitochondrial DNA metabolism", "down regulation of mitochondrial DNA metabolism", "down regulation of mtDNA metabolic process", "down-regulation of mtDNA metabolic process", "down-regulation of mtDNA metabolism", "downregulation of mitochondrial DNA metabolic process", "negative regulation of mtDNA metabolism", "downregulation of mtDNA metabolic process", "down-regulation of mitochondrial DNA metabolic process", "downregulation of mitochondrial DNA metabolism", "downregulation of mtDNA metabolism", "inhibition of mtDNA metabolism", "inhibition of mtDNA metabolic process"], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial DNA metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process. [GOC:TermGenie, GOC:yaf, PMID:23150719]"}
{"concept_id": "C3546913", "aliases": ["regulation of mtDNA metabolic process", "regulation of mitochondrial DNA metabolism", "regulation of mtDNA metabolism"], "types": ["T045"], "canonical_name": "regulation of mitochondrial DNA metabolic process", "definition": "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process. [GOC:TermGenie, GOC:yaf, PMID:23150719]"}
{"concept_id": "C3546914", "aliases": ["up-regulation of oxidative metabolic process", "activation of oxidative metabolic process", "positive regulation of oxidative metabolism", "up-regulation of cellular respiration", "up-regulation of oxidative metabolism", "activation of oxidative metabolism", "upregulation of cellular respiration", "up regulation of oxidative metabolic process", "positive regulation of oxidative metabolic process", "upregulation of oxidative metabolism", "upregulation of oxidative metabolic process", "up regulation of cellular respiration", "up regulation of oxidative metabolism"], "types": ["T043"], "canonical_name": "positive regulation of cellular respiration", "definition": "Any process that activates or increases the frequency, rate or extent of cellular respiration. [GOC:TermGenie, GOC:yaf, PMID:23150719]"}
{"concept_id": "C3546915", "aliases": ["inhibition of oxidative metabolic process", "negative regulation of oxidative metabolic process", "down regulation of oxidative metabolic process", "down-regulation of oxidative metabolic process", "inhibition of oxidative metabolism", "downregulation of cellular respiration", "down regulation of oxidative metabolism", "downregulation of oxidative metabolic process", "down-regulation of oxidative metabolism", "down regulation of cellular respiration", "down-regulation of cellular respiration", "downregulation of oxidative metabolism", "negative regulation of oxidative metabolism"], "types": ["T043"], "canonical_name": "negative regulation of cellular respiration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration. [GOC:TermGenie, GOC:yaf, PMID:23150719]"}
{"concept_id": "C3546916", "aliases": ["5,6,7,8-tetrahydrosarcinapterin formation", "5,6,7,8-tetrahydrosarcinapterin anabolism", "5,6,7,8-tetrahydrosarcinapterin biosynthesis", "5,6,7,8-tetrahydrosarcinapterin synthesis"], "types": ["T044"], "canonical_name": "5,6,7,8-tetrahydrosarcinapterin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydrosarcinapterin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069]"}
{"concept_id": "C3546917", "aliases": ["5,6,7,8-tetrahydrosarcinapterin breakdown", "5,6,7,8-tetrahydrosarcinapterin catabolism", "5,6,7,8-tetrahydrosarcinapterin degradation"], "types": ["T044"], "canonical_name": "5,6,7,8-tetrahydrosarcinapterin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydrosarcinapterin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069]"}
{"concept_id": "C3546918", "aliases": ["5,6,7,8-tetrahydrosarcinapterin metabolism"], "types": ["T044"], "canonical_name": "5,6,7,8-tetrahydrosarcinapterin metabolic process", "definition": "The chemical reactions and pathways involving 5,6,7,8-tetrahydrosarcinapterin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069]"}
{"concept_id": "C3546919", "aliases": ["coenzyme F0 synthesis", "7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis", "coenzyme F0 anabolism", "coenzyme F0 biosynthesis", "coenzyme F0 biosynthetic process", "7,8-didemethyl-8-hydroxy-5-deazariboflavin anabolism", "coenzyme F0 formation", "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthesis", "7,8-didemethyl-8-hydroxy-5-deazariboflavin formation"], "types": ["T044"], "canonical_name": "7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 7,8-didemethyl-8-hydroxy-5-deazariboflavin. [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072]"}
{"concept_id": "C3546920", "aliases": ["coenzyme F0 catabolic process", "coenzyme F0 breakdown", "coenzyme F0 catabolism", "7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolism", "coenzyme F0 degradation", "7,8-didemethyl-8-hydroxy-5-deazariboflavin degradation", "7,8-didemethyl-8-hydroxy-5-deazariboflavin breakdown"], "types": ["T044"], "canonical_name": "7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 7,8-didemethyl-8-hydroxy-5-deazariboflavin. [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072]"}
{"concept_id": "C3546921", "aliases": ["coenzyme F0 metabolism", "7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolism"], "types": ["T044"], "canonical_name": "7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process", "definition": "The chemical reactions and pathways involving 7,8-didemethyl-8-hydroxy-5-deazariboflavin. [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072]"}
{"concept_id": "C3546922", "aliases": ["nicotinate formation", "nicotinate biosynthesis", "nicotinate synthesis", "nicotinate anabolism"], "types": ["T044"], "canonical_name": "nicotinate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nicotinate. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]"}
{"concept_id": "C3546923", "aliases": ["nicotinate catabolism", "nicotinate degradation", "nicotinate breakdown"], "types": ["T044"], "canonical_name": "nicotinate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nicotinate. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]"}
{"concept_id": "C3546924", "aliases": ["nicotinate metabolism"], "types": ["T044"], "canonical_name": "nicotinate metabolic process", "definition": "The chemical reactions and pathways involving nicotinate. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]"}
{"concept_id": "C3546925", "aliases": ["up-regulation of cell communication by electrical coupling involved in cardiac conduction", "upregulation of cell communication by electrical coupling involved in cardiac conduction", "up regulation of cell communication by electrical coupling involved in cardiac conduction"], "types": ["T043"], "canonical_name": "positive regulation of cell communication by electrical coupling involved in cardiac conduction", "definition": "Any process that activates or increases the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]"}
{"concept_id": "C3546926", "aliases": ["down-regulation of cell communication by electrical coupling involved in cardiac conduction", "down regulation of cell communication by electrical coupling involved in cardiac conduction", "downregulation of cell communication by electrical coupling involved in cardiac conduction"], "types": ["T043"], "canonical_name": "negative regulation of cell communication by electrical coupling involved in cardiac conduction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]"}
{"concept_id": "C3546927", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell communication by electrical coupling involved in cardiac conduction", "definition": "Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]"}
{"concept_id": "C3546928", "aliases": ["positive regulation of high voltage-dependent calcium channel activity", "up regulation of high voltage gated calcium channel activity", "up regulation of high voltage-dependent calcium channel activity", "activation of high voltage gated calcium channel activity", "up-regulation of high voltage-gated calcium channel activity", "up-regulation of high voltage gated calcium channel activity", "up regulation of high voltage-gated calcium channel activity", "upregulation of high voltage gated calcium channel activity", "activation of high voltage-gated calcium channel activity", "upregulation of high voltage-dependent calcium channel activity", "upregulation of high voltage-gated calcium channel activity", "up-regulation of high voltage-dependent calcium channel activity", "activation of high voltage-dependent calcium channel activity", "positive regulation of high voltage gated calcium channel activity"], "types": ["T044"], "canonical_name": "positive regulation of high voltage-gated calcium channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]"}
{"concept_id": "C3546929", "aliases": ["inhibition of high voltage gated calcium channel activity", "downregulation of high voltage-gated calcium channel activity", "downregulation of high voltage gated calcium channel activity", "inhibition of high voltage-gated calcium channel activity", "negative regulation of high voltage-dependent calcium channel activity", "down-regulation of high voltage gated calcium channel activity", "down regulation of high voltage-dependent calcium channel activity", "down regulation of high voltage gated calcium channel activity", "down-regulation of high voltage-gated calcium channel activity", "down-regulation of high voltage-dependent calcium channel activity", "downregulation of high voltage-dependent calcium channel activity", "inhibition of high voltage-dependent calcium channel activity", "down regulation of high voltage-gated calcium channel activity", "negative regulation of high voltage gated calcium channel activity"], "types": ["T044"], "canonical_name": "negative regulation of high voltage-gated calcium channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of high voltage-gated calcium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]"}
{"concept_id": "C3546930", "aliases": ["regulation of high voltage-dependent calcium channel activity", "regulation of high voltage gated calcium channel activity"], "types": ["T044"], "canonical_name": "regulation of high voltage-gated calcium channel activity", "definition": "Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]"}
{"concept_id": "C3546931", "aliases": ["down regulation of RNA polymerase I regulatory region sequence-specific DNA binding", "down-regulation of RNA polymerase I regulatory region sequence-specific DNA binding", "downregulation of RNA polymerase I regulatory region sequence-specific DNA binding"], "types": ["T044"], "canonical_name": "negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3546932", "aliases": [], "types": ["T045"], "canonical_name": "regulation of RNA polymerase I regulatory region sequence-specific DNA binding", "definition": "Any process that modulates the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3546933", "aliases": ["up-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter", "upregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter", "up regulation of transcription of nuclear rRNA large Pol I transcript", "positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter", "up regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter", "positive regulation of transcription of nuclear rRNA large Pol I transcript", "upregulation of transcription of nuclear rRNA large Pol I transcript", "activation of transcription of nuclear rRNA large Pol I transcript", "up-regulation of transcription of nuclear rRNA large Pol I transcript"], "types": ["T045"], "canonical_name": "positive regulation of transcription of nucleolar large rRNA by RNA polymerase I", "definition": "Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3546934", "aliases": ["downregulation of transcription of nuclear rRNA large Pol I transcript", "down-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter", "inhibition of transcription of nuclear rRNA large Pol I transcript", "negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter", "downregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter", "negative regulation of transcription of nuclear rRNA large Pol I transcript", "down regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter", "down regulation of transcription of nuclear rRNA large Pol I transcript", "down-regulation of transcription of nuclear rRNA large Pol I transcript"], "types": ["T045"], "canonical_name": "negative regulation of transcription of nucleolar large rRNA by RNA polymerase I", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3546935", "aliases": ["regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter", "regulation of transcription of nuclear rRNA large Pol I transcript"], "types": ["T045"], "canonical_name": "regulation of transcription of nucleolar large rRNA by RNA polymerase I", "definition": "Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3546936", "aliases": ["up-regulation of deadenylation-independent decapping of nuclear-transcribed mRNA", "activation of deadenylylation-independent decapping", "up regulation of deadenylylation-independent decapping", "upregulation of deadenylation-independent decapping of nuclear-transcribed mRNA", "up regulation of deadenylation-independent decapping of nuclear-transcribed mRNA", "up-regulation of deadenylylation-independent decapping", "upregulation of deadenylylation-independent decapping", "positive regulation of deadenylylation-independent decapping"], "types": ["T044"], "canonical_name": "positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA", "definition": "Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA. [GOC:TermGenie]"}
{"concept_id": "C3546937", "aliases": ["regulation of deadenylylation-independent decapping"], "types": ["T044"], "canonical_name": "regulation of deadenylation-independent decapping of nuclear-transcribed mRNA", "definition": "Any process that modulates the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA. [GOC:TermGenie]"}
{"concept_id": "C3546938", "aliases": ["neoxanthin biosynthesis", "neoxanthin biosynthetic process", "all-trans-neoxanthin anabolism", "neoxanthin synthesis", "all-trans-neoxanthin biosynthesis", "all-trans-neoxanthin synthesis", "all-trans-neoxanthin formation", "neoxanthin formation", "neoxanthin anabolism"], "types": ["T044"], "canonical_name": "all-trans-neoxanthin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of all-trans-neoxanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]"}
{"concept_id": "C3546939", "aliases": ["neoxanthin catabolic process", "all-trans-neoxanthin degradation", "all-trans-neoxanthin catabolism", "neoxanthin breakdown", "neoxanthin catabolism", "all-trans-neoxanthin breakdown", "neoxanthin degradation"], "types": ["T044"], "canonical_name": "all-trans-neoxanthin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of all-trans-neoxanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]"}
{"concept_id": "C3546940", "aliases": ["neoxanthin metabolism", "all-trans-neoxanthin metabolism", "neoxanthin metabolic process"], "types": ["T044"], "canonical_name": "all-trans-neoxanthin metabolic process", "definition": "The chemical reactions and pathways involving all-trans-neoxanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]"}
{"concept_id": "C3546941", "aliases": ["zeaxanthin bis(beta-D-glucoside) formation", "zeaxanthin diglucoside formation", "zeaxanthin bis(beta-D-glucoside) synthesis", "zeaxanthin diglucoside anabolism", "zeaxanthin bis(beta-D-glucoside) biosynthesis", "zeaxanthin diglucoside biosynthesis", "zeaxanthin bis(beta-D-glucoside) anabolism", "zeaxanthin diglucoside synthesis"], "types": ["T044"], "canonical_name": "zeaxanthin bis(beta-D-glucoside) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of zeaxanthin bis(beta-D-glucoside). [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798]"}
{"concept_id": "C3546942", "aliases": ["zeaxanthin diglucoside breakdown", "zeaxanthin diglucoside degradation", "zeaxanthin diglucoside catabolism", "zeaxanthin bis(beta-D-glucoside) catabolism", "zeaxanthin bis(beta-D-glucoside) degradation", "zeaxanthin bis(beta-D-glucoside) breakdown"], "types": ["T044"], "canonical_name": "zeaxanthin bis(beta-D-glucoside) catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of zeaxanthin bis(beta-D-glucoside). [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798]"}
{"concept_id": "C3546943", "aliases": ["zeaxanthin diglucoside metabolism", "zeaxanthin bis(beta-D-glucoside) metabolism"], "types": ["T044"], "canonical_name": "zeaxanthin bis(beta-D-glucoside) metabolic process", "definition": "The chemical reactions and pathways involving zeaxanthin bis(beta-D-glucoside). [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798]"}
{"concept_id": "C3546944", "aliases": ["zeaxanthin anabolism", "zeaxanthin formation", "zeaxanthin biosynthesis", "zeaxanthin synthesis"], "types": ["T044"], "canonical_name": "zeaxanthin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of zeaxanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]"}
{"concept_id": "C3546945", "aliases": ["zeaxanthin catabolism", "zeaxanthin degradation", "zeaxanthin breakdown"], "types": ["T044"], "canonical_name": "zeaxanthin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of zeaxanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]"}
{"concept_id": "C3546946", "aliases": ["delta-carotene biosynthesis", "delta-carotene anabolism", "delta-carotene formation", "delta-carotene synthesis"], "types": ["T044"], "canonical_name": "delta-carotene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of delta-carotene. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]"}
{"concept_id": "C3546947", "aliases": ["delta-carotene breakdown", "delta-carotene catabolism", "delta-carotene degradation"], "types": ["T044"], "canonical_name": "delta-carotene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of delta-carotene. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]"}
{"concept_id": "C3546948", "aliases": ["delta-carotene metabolism"], "types": ["T044"], "canonical_name": "delta-carotene metabolic process", "definition": "The chemical reactions and pathways involving delta-carotene. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]"}
{"concept_id": "C3546949", "aliases": ["alpha-zeacarotene synthesis", "alpha-zeacarotene anabolism", "alpha-zeacarotene biosynthesis", "alpha-zeacarotene formation"], "types": ["T044"], "canonical_name": "alpha-zeacarotene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alpha-zeacarotene. [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804]"}
{"concept_id": "C3546950", "aliases": ["alpha-zeacarotene degradation", "alpha-zeacarotene breakdown", "alpha-zeacarotene catabolism"], "types": ["T044"], "canonical_name": "alpha-zeacarotene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of alpha-zeacarotene. [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804]"}
{"concept_id": "C3546951", "aliases": ["alpha-zeacarotene metabolism"], "types": ["T044"], "canonical_name": "alpha-zeacarotene metabolic process", "definition": "The chemical reactions and pathways involving alpha-zeacarotene. [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804]"}
{"concept_id": "C3546952", "aliases": ["beta-zeacarotene anabolism", "beta-zeacarotene synthesis", "beta-zeacarotene biosynthesis", "beta-zeacarotene formation"], "types": ["T044"], "canonical_name": "beta-zeacarotene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-zeacarotene. [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805]"}
{"concept_id": "C3546953", "aliases": ["beta-zeacarotene breakdown", "beta-zeacarotene degradation", "beta-zeacarotene catabolism"], "types": ["T044"], "canonical_name": "beta-zeacarotene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of beta-zeacarotene. [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805]"}
{"concept_id": "C3546954", "aliases": ["beta-zeacarotene metabolism"], "types": ["T044"], "canonical_name": "beta-zeacarotene metabolic process", "definition": "The chemical reactions and pathways involving beta-zeacarotene. [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805]"}
{"concept_id": "C3546955", "aliases": ["astaxanthin synthesis", "astaxanthin formation", "astaxanthin anabolism", "astaxanthin biosynthesis"], "types": ["T044"], "canonical_name": "astaxanthin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of astaxanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]"}
{"concept_id": "C3546956", "aliases": ["astaxanthin degradation", "astaxanthin catabolism", "astaxanthin breakdown"], "types": ["T044"], "canonical_name": "astaxanthin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of astaxanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]"}
{"concept_id": "C3546957", "aliases": ["astaxanthin metabolism"], "types": ["T044"], "canonical_name": "astaxanthin metabolic process", "definition": "The chemical reactions and pathways involving astaxanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]"}
{"concept_id": "C3546958", "aliases": ["beta-carotene synthesis", "beta-carotene anabolism", "beta-carotene biosynthesis", "beta-carotene formation"], "types": ["T044"], "canonical_name": "beta-carotene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-carotene. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]"}
{"concept_id": "C3546959", "aliases": ["beta-carotene breakdown", "beta-carotene degradation", "beta-carotene catabolism"], "types": ["T044"], "canonical_name": "beta-carotene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of beta-carotene. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]"}
{"concept_id": "C3546960", "aliases": ["beta-carotene metabolism"], "types": ["T044"], "canonical_name": "beta-carotene metabolic process", "definition": "The chemical reactions and pathways involving beta-carotene. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]"}
{"concept_id": "C3546961", "aliases": ["capsanthin formation", "capsanthin anabolism", "capsanthin synthesis", "capsanthin biosynthesis"], "types": ["T044"], "canonical_name": "capsanthin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of capsanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]"}
{"concept_id": "C3546962", "aliases": ["capsanthin breakdown", "capsanthin degradation", "capsanthin catabolism"], "types": ["T044"], "canonical_name": "capsanthin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of capsanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]"}
{"concept_id": "C3546963", "aliases": ["capsanthin metabolism"], "types": ["T044"], "canonical_name": "capsanthin metabolic process", "definition": "The chemical reactions and pathways involving capsanthin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]"}
{"concept_id": "C3546964", "aliases": ["beta-glucoside anabolism", "beta-glucoside formation", "beta-glucoside synthesis", "beta-glucoside biosynthesis"], "types": ["T044"], "canonical_name": "beta-glucoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-glucoside. [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237]"}
{"concept_id": "C3546965", "aliases": ["beta-glucoside degradation", "beta-glucoside catabolism", "beta-glucoside breakdown"], "types": ["T044"], "canonical_name": "beta-glucoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of beta-glucoside. [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237]"}
{"concept_id": "C3546966", "aliases": ["beta-glucoside metabolism"], "types": ["T044"], "canonical_name": "beta-glucoside metabolic process", "definition": "The chemical reactions and pathways involving beta-glucoside. [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237]"}
{"concept_id": "C3546967", "aliases": ["1,5-anhydro-D-fructose anabolism", "1,5-anhydro-D-fructose formation", "1,5-anhydro-D-fructose synthesis", "1,5-anhydro-D-fructose biosynthesis"], "types": ["T044"], "canonical_name": "1,5-anhydro-D-fructose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 1,5-anhydro-D-fructose. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738]"}
{"concept_id": "C3546968", "aliases": ["1,5-anhydro-D-fructose breakdown", "1,5-anhydro-D-fructose degradation", "1,5-anhydro-D-fructose catabolism"], "types": ["T044"], "canonical_name": "1,5-anhydro-D-fructose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1,5-anhydro-D-fructose. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738]"}
{"concept_id": "C3546969", "aliases": ["1,5-anhydro-D-fructose metabolism"], "types": ["T044"], "canonical_name": "1,5-anhydro-D-fructose metabolic process", "definition": "The chemical reactions and pathways involving 1,5-anhydro-D-fructose. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738]"}
{"concept_id": "C3546970", "aliases": ["positive regulation of proteasome-mediated protein catabolism", "up-regulation of proteasome-mediated protein catabolism", "upregulation of proteasome-mediated protein catabolism", "up-regulation of proteasomal protein catabolic process", "upregulation of proteasome-mediated protein catabolic process", "activation of proteasome-mediated protein catabolic process", "up regulation of proteasome-mediated protein catabolism", "up-regulation of proteasome-mediated protein catabolic process", "positive regulation of proteasome-mediated protein catabolic process", "up regulation of proteasome-mediated protein catabolic process", "activation of proteasome-mediated protein catabolism", "up regulation of proteasomal protein catabolic process", "upregulation of proteasomal protein catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of proteasomal protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]"}
{"concept_id": "C3546971", "aliases": ["down regulation of proteasome-mediated protein catabolic process", "negative regulation of proteasome-mediated protein catabolism", "inhibition of proteasome-mediated protein catabolic process", "negative regulation of proteasome-mediated protein catabolic process", "downregulation of proteasome-mediated protein catabolic process", "down-regulation of proteasome-mediated protein catabolic process", "down regulation of proteasomal protein catabolic process", "down-regulation of proteasomal protein catabolic process", "downregulation of proteasome-mediated protein catabolism", "downregulation of proteasomal protein catabolic process", "down-regulation of proteasome-mediated protein catabolism", "down regulation of proteasome-mediated protein catabolism", "inhibition of proteasome-mediated protein catabolism"], "types": ["T044"], "canonical_name": "negative regulation of proteasomal protein catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]"}
{"concept_id": "C3546972", "aliases": ["up regulation of signal transduction by p53 class mediator", "up-regulation of signal transduction by p53 class mediator", "upregulation of signal transduction by p53 class mediator"], "types": ["T044"], "canonical_name": "positive regulation of signal transduction by p53 class mediator", "definition": "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie]"}
{"concept_id": "C3546973", "aliases": ["down regulation of signal transduction by p53 class mediator", "downregulation of signal transduction by p53 class mediator", "down-regulation of signal transduction by p53 class mediator"], "types": ["T044"], "canonical_name": "negative regulation of signal transduction by p53 class mediator", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie]"}
{"concept_id": "C3546974", "aliases": [], "types": ["T044"], "canonical_name": "regulation of signal transduction by p53 class mediator", "definition": "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie]"}
{"concept_id": "C3546975", "aliases": ["3-(3-hydroxyphenyl)propanoate formation", "3-(3-hydroxyphenyl)propanoate anabolism", "3-(3-hydroxyphenyl)propanoate biosynthesis", "3-(3-hydroxyphenyl)propanoate synthesis"], "types": ["T044"], "canonical_name": "3-(3-hydroxyphenyl)propanoate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 3-(3-hydroxyphenyl)propanoate. [GOC:TermGenie, GOC:yaf, PMID:10537203]"}
{"concept_id": "C3546976", "aliases": ["3-(3-hydroxyphenyl)propanoate degradation", "3-(3-hydroxyphenyl)propanoate breakdown", "3-(3-hydroxyphenyl)propanoate catabolism"], "types": ["T044"], "canonical_name": "3-(3-hydroxyphenyl)propanoate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxyphenyl)propanoate. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY0-1277, PMID:10537203, UniPathway:UPA00835]"}
{"concept_id": "C3546977", "aliases": ["3-(3-hydroxyphenyl)propanoate metabolism"], "types": ["T044"], "canonical_name": "3-(3-hydroxyphenyl)propanoate metabolic process", "definition": "The chemical reactions and pathways involving 3-(3-hydroxyphenyl)propanoate. [GOC:TermGenie, GOC:yaf, PMID:10537203]"}
{"concept_id": "C3546978", "aliases": ["3-(2,3-dihydroxyphenyl)propanoate synthesis", "3-(2,3-dihydroxyphenyl)propanoate anabolism", "3-(2,3-dihydroxyphenyl)propanoate formation", "3-(2,3-dihydroxyphenyl)propanoate biosynthesis"], "types": ["T044"], "canonical_name": "3-(2,3-dihydroxyphenyl)propanoate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 3-(2,3-dihydroxyphenyl)propanoate. [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY]"}
{"concept_id": "C3546979", "aliases": ["3-(2,3-dihydroxyphenyl)propanoate breakdown", "3-(2,3-dihydroxyphenyl)propanoate degradation", "3-(2,3-dihydroxyphenyl)propanoate catabolism"], "types": ["T044"], "canonical_name": "3-(2,3-dihydroxyphenyl)propanoate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3-(2,3-dihydroxyphenyl)propanoate. [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY, UniPathway:UPA00836]"}
{"concept_id": "C3546980", "aliases": ["3-(2,3-dihydroxyphenyl)propanoate metabolism"], "types": ["T044"], "canonical_name": "3-(2,3-dihydroxyphenyl)propanoate metabolic process", "definition": "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate. [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY]"}
{"concept_id": "C3546981", "aliases": ["benzoyl-CoA formation", "benzoyl-CoA anabolism", "benzoyl-CoA biosynthesis", "benzoyl-CoA synthesis"], "types": ["T044"], "canonical_name": "benzoyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of benzoyl-CoA. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3546982", "aliases": ["benzoyl-CoA catabolism", "benzoyl-CoA breakdown", "benzoyl-CoA degradation"], "types": ["T044"], "canonical_name": "benzoyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA. [GOC:TermGenie, GOC:yaf, MetaCyc:CENTBENZCOA-PWY, MetaCyc:P321-PWY, MetaCyc:PWY-1361, UniPathway:UPA00739]"}
{"concept_id": "C3546983", "aliases": ["benzoyl-CoA metabolism"], "types": ["T044"], "canonical_name": "benzoyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving benzoyl-CoA. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3546984", "aliases": ["p-cresol anabolism", "p-cresol biosynthesis", "p-cresol synthesis", "p-cresol formation"], "types": ["T044"], "canonical_name": "p-cresol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of p-cresol. [GOC:TermGenie, GOC:yaf, PMID:10623531]"}
{"concept_id": "C3546985", "aliases": ["p-cresol catabolism", "p-cresol degradation", "p-cresol breakdown"], "types": ["T044"], "canonical_name": "p-cresol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of p-cresol. [GOC:TermGenie, GOC:yaf, PMID:10623531, UniPathway:UPA00708]"}
{"concept_id": "C3546986", "aliases": ["p-cresol metabolism"], "types": ["T044"], "canonical_name": "p-cresol metabolic process", "definition": "The chemical reactions and pathways involving p-cresol. [GOC:TermGenie, GOC:yaf, PMID:10623531]"}
{"concept_id": "C3546987", "aliases": ["p-cumate biosynthesis", "p-cumate anabolism", "p-cumate formation", "p-cumate synthesis"], "types": ["T044"], "canonical_name": "p-cumate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of p-cumate. [GOC:TermGenie, GOC:yaf, PMID:8631713]"}
{"concept_id": "C3546988", "aliases": ["p-cumate degradation", "p-cumate catabolism", "p-cumate breakdown"], "types": ["T044"], "canonical_name": "p-cumate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of p-cumate. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5273, PMID:8631713, UniPathway:UPA00937]"}
{"concept_id": "C3546989", "aliases": ["p-cumate metabolism"], "types": ["T044"], "canonical_name": "p-cumate metabolic process", "definition": "The chemical reactions and pathways involving p-cumate. [GOC:TermGenie, GOC:yaf, PMID:8631713]"}
{"concept_id": "C3546990", "aliases": ["pentalenolactone anabolism", "pentalenolactone formation", "pentalenolactone biosynthesis", "pentalenolactone synthesis"], "types": ["T044"], "canonical_name": "pentalenolactone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pentalenolactone. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6915, PMID:17178094, UniPathway:UPA00974]"}
{"concept_id": "C3546991", "aliases": ["pentalenolactone catabolism", "pentalenolactone degradation", "pentalenolactone breakdown"], "types": ["T044"], "canonical_name": "pentalenolactone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pentalenolactone. [GOC:TermGenie, GOC:yaf, PMID:17178094]"}
{"concept_id": "C3546992", "aliases": ["pentalenolactone metabolism"], "types": ["T044"], "canonical_name": "pentalenolactone metabolic process", "definition": "The chemical reactions and pathways involving pentalenolactone. [GOC:TermGenie, GOC:yaf, PMID:17178094]"}
{"concept_id": "C3546993", "aliases": ["mitomycin C formation", "mitomycin C synthesis", "mitomycin C anabolism", "mitomycin C biosynthesis"], "types": ["T044"], "canonical_name": "mitomycin C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mitomycin C. [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135, UniPathway:UPA00851]"}
{"concept_id": "C3546994", "aliases": ["mitomycin C breakdown", "mitomycin C degradation", "mitomycin C catabolism"], "types": ["T044"], "canonical_name": "mitomycin C catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mitomycin C. [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135]"}
{"concept_id": "C3546995", "aliases": ["lincomycin synthesis", "lincomycin biosynthesis", "lincomycin formation", "lincomycin anabolism"], "types": ["T044"], "canonical_name": "lincomycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lincomycin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6955, PMID:8577249, UniPathway:UPA00161]"}
{"concept_id": "C3546996", "aliases": ["lincomycin catabolism", "lincomycin degradation", "lincomycin breakdown"], "types": ["T044"], "canonical_name": "lincomycin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lincomycin. [GOC:TermGenie, GOC:yaf, PMID:8577249]"}
{"concept_id": "C3546997", "aliases": ["lincomycin metabolism"], "types": ["T044"], "canonical_name": "lincomycin metabolic process", "definition": "The chemical reactions and pathways involving lincomycin. [GOC:TermGenie, GOC:yaf, PMID:8577249]"}
{"concept_id": "C3546998", "aliases": ["daunorubicin biosynthesis", "daunorubicin anabolism", "daunorubicin formation", "daunorubicin synthesis"], "types": ["T044"], "canonical_name": "daunorubicin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of daunorubicin. [GOC:TermGenie, GOC:yaf, PMID:7601857, UniPathway:UPA00054]"}
{"concept_id": "C3546999", "aliases": ["daunorubicin breakdown", "daunorubicin degradation", "daunorubicin catabolism"], "types": ["T044"], "canonical_name": "daunorubicin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of daunorubicin. [GOC:TermGenie, GOC:yaf, PMID:7601857]"}
{"concept_id": "C3547000", "aliases": ["carbapenem formation", "carbapenem anabolism", "carbapenem biosynthesis", "carbapenem synthesis"], "types": ["T044"], "canonical_name": "carbapenem biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of carbapenem. [GOC:TermGenie, GOC:yaf, PMID:9402024, UniPathway:UPA00182]"}
{"concept_id": "C3547001", "aliases": ["carbapenem breakdown", "carbapenem catabolism", "carbapenem degradation"], "types": ["T044"], "canonical_name": "carbapenem catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carbapenem. [GOC:TermGenie, GOC:yaf, PMID:9402024]"}
{"concept_id": "C3547002", "aliases": ["carbapenem metabolism"], "types": ["T044"], "canonical_name": "carbapenem metabolic process", "definition": "The chemical reactions and pathways involving carbapenem. [GOC:TermGenie, GOC:yaf, PMID:9402024]"}
{"concept_id": "C3547003", "aliases": ["phosphinothricin anabolism", "phosphinothricin biosynthesis", "phosphinothricin formation", "phosphinothricin synthesis"], "types": ["T044"], "canonical_name": "phosphinothricin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphinothricin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00168]"}
{"concept_id": "C3547004", "aliases": ["phosphinothricin catabolism", "phosphinothricin degradation", "phosphinothricin breakdown"], "types": ["T044"], "canonical_name": "phosphinothricin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of phosphinothricin. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547005", "aliases": ["phosphinothricin metabolism"], "types": ["T044"], "canonical_name": "phosphinothricin metabolic process", "definition": "The chemical reactions and pathways involving phosphinothricin. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547006", "aliases": ["oxytetracycline anabolism", "oxytetracycline formation", "oxytetracycline synthesis", "oxytetracycline biosynthesis"], "types": ["T044"], "canonical_name": "oxytetracycline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of oxytetracycline. [GOC:TermGenie, GOC:yaf, PMID:8163168, UniPathway:UPA00926]"}
{"concept_id": "C3547007", "aliases": ["oxytetracycline degradation", "oxytetracycline breakdown", "oxytetracycline catabolism"], "types": ["T044"], "canonical_name": "oxytetracycline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of oxytetracycline. [GOC:TermGenie, GOC:yaf, PMID:8163168]"}
{"concept_id": "C3547008", "aliases": ["4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis", "beta-L-Ara4N-lipid A anabolism", "beta-L-Ara4N-lipid A synthesis", "beta-L-Ara4N-lipid A formation", "beta-L-Ara4N-lipid A biosynthesis", "4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthetic process"], "types": ["T044"], "canonical_name": "beta-L-Ara4N-lipid A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-L-Ara4N-lipid A which occurs as a result of modification of the lipid A moiety of lipopolysaccharide by the addition of the sugar 4-amino-4-deoxy-L-arabinose (L-Ara4N). This strategy is adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system. [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326, UniPathway:UPA00037]"}
{"concept_id": "C3547009", "aliases": ["4-amino-4-deoxy-beta-L-arabinose-lipid A metabolic process", "4-amino-4-deoxy-beta-L-arabinose-lipid A metabolism", "beta-L-Ara4N-lipid A metabolism"], "types": ["T044"], "canonical_name": "beta-L-Ara4N-lipid A metabolic process", "definition": "The chemical reactions and pathways involving beta-L-Ara4N-lipid A. [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326]"}
{"concept_id": "C3547010", "aliases": ["butirosin biosynthesis", "butirosin formation", "butirosin anabolism", "butirosin synthesis"], "types": ["T044"], "canonical_name": "butirosin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of butirosin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00964]"}
{"concept_id": "C3547011", "aliases": ["butirosin catabolism", "butirosin degradation", "butirosin breakdown"], "types": ["T044"], "canonical_name": "butirosin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of butirosin. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547012", "aliases": ["butirosin metabolism"], "types": ["T044"], "canonical_name": "butirosin metabolic process", "definition": "The chemical reactions and pathways involving butirosin. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547013", "aliases": ["vitamin D3 catabolism", "calciol degradation", "vitamin D3 degradation", "cholecalciferol catabolic process", "vitamin D3 breakdown", "cholecalciferol catabolism", "calciol catabolism", "calciol breakdown", "calciol catabolic process"], "types": ["T044"], "canonical_name": "vitamin D3 catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of vitamin D3. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547014", "aliases": ["leukotriene A4 biosynthesis", "leukotriene A4 synthesis", "leukotriene A4 anabolism", "leukotriene A4 formation", "eoxin A4 biosynthesis", "LTA4 biosynthesis"], "types": ["T044"], "canonical_name": "leukotriene A4 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of leukotriene A4. [GOC:TermGenie, GOC:yaf, PMID:23242647]"}
{"concept_id": "C3547015", "aliases": ["leukotriene A4 catabolism", "leukotriene A4 breakdown", "leukotriene A4 degradation"], "types": ["T044"], "canonical_name": "leukotriene A4 catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of leukotriene A4. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547016", "aliases": ["leukotriene A4 metabolism"], "types": ["T044"], "canonical_name": "leukotriene A4 metabolic process", "definition": "The chemical reactions and pathways involving leukotriene A4. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547017", "aliases": ["leukotriene D4 biosynthesis", "leukotriene D4 formation", "leukotriene D4 anabolism", "leukotriene D4 synthesis"], "types": ["T044"], "canonical_name": "leukotriene D4 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of leukotriene D4. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00880]"}
{"concept_id": "C3547018", "aliases": ["leukotriene D4 catabolism", "leukotriene D4 breakdown", "leukotriene D4 degradation"], "types": ["T044"], "canonical_name": "leukotriene D4 catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of leukotriene D4. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547019", "aliases": ["leukotriene D4 metabolism"], "types": ["T044"], "canonical_name": "leukotriene D4 metabolic process", "definition": "The chemical reactions and pathways involving leukotriene D4. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547020", "aliases": ["prephenate synthesis", "prephenate formation", "prephenate biosynthesis", "prephenate(2-) biosynthesis", "prephenate(2-) anabolism", "prephenate(2-) synthesis", "prephenate anabolism", "prephenate(2-) formation"], "types": ["T044"], "canonical_name": "prephenate(2-) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of prephenate(2-). [GOC:TermGenie, GOC:yaf, PMID:16752890, UniPathway:UPA00120]"}
{"concept_id": "C3547021", "aliases": ["prephenate(2-) catabolism", "prephenate breakdown", "prephenate degradation", "prephenate(2-) degradation", "prephenate catabolism", "prephenate(2-) breakdown"], "types": ["T044"], "canonical_name": "prephenate(2-) catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of prephenate(2-). [GOC:TermGenie, GOC:yaf, PMID:16752890]"}
{"concept_id": "C3547022", "aliases": ["2-deoxystreptamine anabolism", "2-deoxystreptamine biosynthesis", "2-deoxystreptamine formation", "2-deoxystreptamine synthesis"], "types": ["T044"], "canonical_name": "2-deoxystreptamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 2-deoxystreptamine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00907]"}
{"concept_id": "C3547023", "aliases": ["2-deoxystreptamine catabolism", "2-deoxystreptamine degradation", "2-deoxystreptamine breakdown"], "types": ["T044"], "canonical_name": "2-deoxystreptamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-deoxystreptamine. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547024", "aliases": ["2-deoxystreptamine metabolism"], "types": ["T044"], "canonical_name": "2-deoxystreptamine metabolic process", "definition": "The chemical reactions and pathways involving 2-deoxystreptamine. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547025", "aliases": ["up-regulation of myoblast fusion", "upregulation of myoblast fusion", "up regulation of myoblast fusion"], "types": ["T043"], "canonical_name": "positive regulation of myoblast fusion", "definition": "Any process that activates or increases the frequency, rate or extent of myoblast fusion. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]"}
{"concept_id": "C3547026", "aliases": ["down regulation of myoblast fusion", "downregulation of myoblast fusion", "down-regulation of myoblast fusion"], "types": ["T043"], "canonical_name": "negative regulation of myoblast fusion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast fusion. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]"}
{"concept_id": "C3547027", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myoblast fusion", "definition": "Any process that modulates the frequency, rate or extent of myoblast fusion. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]"}
{"concept_id": "C3547028", "aliases": ["regulation of vitamin A metabolism"], "types": ["T044"], "canonical_name": "regulation of vitamin A metabolic process", "definition": "Any process that modulates the frequency, rate or extent of vitamin A metabolic process. [GOC:TermGenie, PMID:18093975]"}
{"concept_id": "C3547029", "aliases": ["(R)-mevalonic acid anabolism", "(R)-mevalonic acid formation", "(R)-mevalonic acid synthesis", "(R)-mevalonic acid biosynthesis", "(R)-mevalonate biosynthesis", "(R)-mevalonate synthesis", "(R)-mevalonate anabolism"], "types": ["T044"], "canonical_name": "(R)-mevalonic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (R)-mevalonic acid. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058]"}
{"concept_id": "C3547030", "aliases": ["(R)-mevalonic acid catabolism", "(R)-mevalonic acid breakdown", "(R)-mevalonate catabolism", "(R)-mevalonic acid degradation", "(R)-mevalonate breakdown", "(R)-mevalonate degradation"], "types": ["T044"], "canonical_name": "(R)-mevalonic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (R)-mevalonic acid. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058]"}
{"concept_id": "C3547031", "aliases": ["(R)-mevalonic acid metabolism", "(R) mevalonate metabolism"], "types": ["T044"], "canonical_name": "(R)-mevalonic acid metabolic process", "definition": "The chemical reactions and pathways involving (R)-mevalonic acid. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058]"}
{"concept_id": "C3547032", "aliases": ["quercetin biosynthesis", "quercetin synthesis", "quercetin formation", "quercetin anabolism"], "types": ["T044"], "canonical_name": "quercetin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of quercetin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]"}
{"concept_id": "C3547033", "aliases": ["quercetin degradation", "quercetin catabolism", "quercetin breakdown"], "types": ["T044"], "canonical_name": "quercetin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of quercetin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]"}
{"concept_id": "C3547034", "aliases": ["quercetin metabolism"], "types": ["T044"], "canonical_name": "quercetin metabolic process", "definition": "The chemical reactions and pathways involving quercetin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]"}
{"concept_id": "C3547035", "aliases": ["up regulation of blood platelet aggregation", "positive regulation of blood platelet aggregation", "upregulation of blood platelet aggregation", "up regulation of platelet aggregation", "up-regulation of blood platelet aggregation", "upregulation of platelet aggregation", "up-regulation of platelet aggregation"], "types": ["T043"], "canonical_name": "positive regulation of platelet aggregation", "definition": "Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:fj, GOC:TermGenie]"}
{"concept_id": "C3547036", "aliases": ["monensin A formation", "monensin synthesis", "monensin A anabolism", "monensin formation", "monensin A synthesis", "monensin A biosynthesis", "monensin anabolism", "monensin biosynthesis"], "types": ["T044"], "canonical_name": "monensin A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of monensin A. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178]"}
{"concept_id": "C3547037", "aliases": ["monensin degradation", "monensin catabolism", "monensin A degradation", "monensin A breakdown", "monensin breakdown", "monensin A catabolism"], "types": ["T044"], "canonical_name": "monensin A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of monensin A. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178]"}
{"concept_id": "C3547038", "aliases": ["monensin metabolism", "monensin A metabolism"], "types": ["T044"], "canonical_name": "monensin A metabolic process", "definition": "The chemical reactions and pathways involving monensin A. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178]"}
{"concept_id": "C3547039", "aliases": ["up regulation of histone deacetylase activity", "up-regulation of histone deacetylase activity", "upregulation of histone deacetylase activity"], "types": ["T044"], "canonical_name": "positive regulation of histone deacetylase activity", "definition": "Any process that activates or increases the frequency, rate or extent of histone deacetylase activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]"}
{"concept_id": "C3547040", "aliases": ["downregulation of histone deacetylase activity", "down-regulation of histone deacetylase activity", "down regulation of histone deacetylase activity"], "types": ["T044"], "canonical_name": "negative regulation of histone deacetylase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone deacetylase activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]"}
{"concept_id": "C3547041", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone deacetylase activity", "definition": "Any process that modulates the frequency, rate or extent of histone deacetylase activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]"}
{"concept_id": "C3547042", "aliases": ["upregulation of cell proliferation involved in kidney development", "up-regulation of cell proliferation involved in kidney development", "up regulation of cell proliferation involved in kidney development"], "types": ["T043"], "canonical_name": "positive regulation of cell proliferation involved in kidney development", "definition": "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in kidney development. [GOC:TermGenie, PMID:18182616]"}
{"concept_id": "C3547043", "aliases": ["down regulation of cell proliferation involved in kidney development", "down-regulation of cell proliferation involved in kidney development", "downregulation of cell proliferation involved in kidney development"], "types": ["T043"], "canonical_name": "negative regulation of cell proliferation involved in kidney development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development. [GOC:TermGenie, PMID:18182616]"}
{"concept_id": "C3547044", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell proliferation involved in kidney development", "definition": "Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development. [GOC:TermGenie, PMID:18182616]"}
{"concept_id": "C3547045", "aliases": ["upregulation of KMN network assembly involved in chromosome segregation", "up regulation of NMS complex interaction involved in chromosome segregation", "up regulation of KMN network assembly involved in chromosome segregation", "upregulation of NMS complex interaction involved in chromosome segregation", "upregulation of KMN complex interaction involved in chromosome segregation", "activation of KMN complex assembly involved in chromosome segregation", "activation of KMN network assembly involved in chromosome segregation", "activation of NMS complex association involved in chromosome segregation", "up regulation of KMN complex interaction involved in chromosome segregation", "up regulation of NMS complex association involved in chromosome segregation", "upregulation of NMS complex association involved in chromosome segregation", "positive regulation of KMN network assembly involved in chromosome segregation", "up-regulation of NMS complex association involved in chromosome segregation", "up-regulation of KMN network assembly involved in chromosome segregation", "positive regulation of NMS complex assembly involved in kinetochore assembly", "up-regulation of NMS complex interaction involved in chromosome segregation", "up-regulation of KMN complex interaction involved in chromosome segregation", "positive regulation of NMS complex association involved in chromosome segregation", "positive regulation of KMN complex interaction involved in chromosome segregation"], "types": ["T043"], "canonical_name": "positive regulation of NMS complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation. [GOC:TermGenie, GOC:vw, PMID:22561345]"}
{"concept_id": "C3547046", "aliases": ["downregulation of KMN complex interaction involved in chromosome segregation", "down regulation of KMN network assembly involved in chromosome segregation", "downregulation of KMN network assembly involved in chromosome segregation", "inhibition of NMS complex association involved in chromosome segregation", "downregulation of NMS complex association involved in chromosome segregation", "negative regulation of KMN network assembly involved in chromosome segregation", "inhibition of KMN network assembly involved in chromosome segregation", "down regulation of KMN complex assembly involved in chromosome segregation", "negative regulation of NMS complex assembly involved in kinetochore assembly", "down-regulation of KMN complex interaction involved in chromosome segregation", "down regulation of NMS complex interaction involved in chromosome segregation", "down regulation of NMS complex association involved in chromosome segregation", "negative regulation of NMS complex association involved in chromosome segregation", "negative regulation of KMN complex interaction involved in chromosome segregation", "inhibition of KMN complex interaction involved in chromosome segregation", "downregulation of NMS complex interaction involved in chromosome segregation", "down-regulation of NMS complex association involved in chromosome segregation", "down-regulation of KMN network assembly involved in chromosome segregation", "down-regulation of NMS complex interaction involved in chromosome segregation"], "types": ["T043"], "canonical_name": "negative regulation of NMS complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation. [GOC:TermGenie, GOC:vw, PMID:22561345]"}
{"concept_id": "C3547047", "aliases": ["regulation of NMS complex assembly involved in kinetochore assembly", "regulation of NMS complex association involved in chromosome segregation", "regulation of KMN complex assembly involved in chromosome segregation", "regulation of KMN network assembly involved in chromosome segregation"], "types": ["T040"], "canonical_name": "regulation of NMS complex assembly", "definition": "Any process that modulates the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation. [GOC:TermGenie, GOC:vw, PMID:22561345]"}
{"concept_id": "C3547049", "aliases": ["upregulation of gamma-aminobutyric acid catabolism", "upregulation of 4-aminobutanoate catabolic process", "activation of GABA catabolism", "activation of 4-aminobutyrate catabolism", "positive regulation of gamma-aminobutyric acid breakdown", "activation of 4-aminobutyrate catabolic process", "up regulation of 4-aminobutanoate catabolic process", "up-regulation of 4-aminobutyrate catabolism", "up-regulation of gamma-aminobutyric acid breakdown", "up regulation of gamma-aminobutyric acid degradation", "up-regulation of GABA catabolism", "upregulation of GABA catabolism", "positive regulation of 4-aminobutyrate catabolism", "up-regulation of GABA catabolic process", "up-regulation of gamma-aminobutyric acid catabolic process", "upregulation of gamma-aminobutyric acid breakdown", "positive regulation of GABA catabolism", "activation of 4-aminobutanoate catabolic process", "upregulation of 4-aminobutyrate catabolic process", "activation of GABA catabolic process", "up regulation of GABA catabolism", "up regulation of 4-aminobutanoate catabolism", "positive regulation of 4-aminobutyrate catabolic process", "activation of 4-aminobutanoate catabolism", "positive regulation of GABA catabolic process", "activation of gamma-aminobutyric acid catabolism", "up regulation of gamma-aminobutyric acid catabolism", "up regulation of gamma-aminobutyric acid breakdown", "positive regulation of 4-aminobutanoate catabolic process", "activation of gamma-aminobutyric acid breakdown", "up regulation of gamma-aminobutyric acid catabolic process", "positive regulation of gamma-aminobutyric acid degradation", "up-regulation of 4-aminobutanoate catabolic process", "up-regulation of gamma-aminobutyric acid degradation", "up regulation of GABA catabolic process", "positive regulation of 4-aminobutanoate catabolism", "upregulation of 4-aminobutyrate catabolism", "positive regulation of gamma-aminobutyric acid catabolism", "upregulation of GABA catabolic process", "up regulation of 4-aminobutyrate catabolic process", "upregulation of gamma-aminobutyric acid degradation", "activation of gamma-aminobutyric acid degradation", "up-regulation of 4-aminobutanoate catabolism", "up-regulation of gamma-aminobutyric acid catabolism", "up-regulation of 4-aminobutyrate catabolic process", "upregulation of gamma-aminobutyric acid catabolic process", "up regulation of 4-aminobutyrate catabolism", "upregulation of 4-aminobutanoate catabolism"], "types": ["T044"], "canonical_name": "positive regulation of gamma-aminobutyric acid catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3547050", "aliases": ["down-regulation of 4-aminobutyrate catabolic process", "negative regulation of gamma-aminobutyric acid breakdown", "down-regulation of gamma-aminobutyric acid breakdown", "downregulation of 4-aminobutanoate catabolic process", "down regulation of gamma-aminobutyric acid degradation", "inhibition of 4-aminobutyrate catabolism", "down-regulation of 4-aminobutanoate catabolic process", "downregulation of GABA catabolic process", "negative regulation of 4-aminobutanoate catabolism", "down-regulation of 4-aminobutyrate catabolism", "down-regulation of gamma-aminobutyric acid degradation", "downregulation of gamma-aminobutyric acid catabolism", "downregulation of gamma-aminobutyric acid breakdown", "inhibition of GABA catabolic process", "negative regulation of 4-aminobutyrate catabolism", "down regulation of gamma-aminobutyric acid breakdown", "downregulation of GABA catabolism", "negative regulation of GABA catabolism", "down-regulation of 4-aminobutanoate catabolism", "negative regulation of 4-aminobutanoate catabolic process", "down regulation of 4-aminobutanoate catabolic process", "inhibition of 4-aminobutanoate catabolism", "down regulation of GABA catabolism", "negative regulation of gamma-aminobutyric acid degradation", "downregulation of gamma-aminobutyric acid catabolic process", "inhibition of 4-aminobutyrate catabolic process", "inhibition of GABA catabolism", "down-regulation of gamma-aminobutyric acid catabolic process", "down regulation of 4-aminobutanoate catabolism", "down regulation of 4-aminobutyrate catabolism", "negative regulation of GABA catabolic process", "inhibition of 4-aminobutanoate catabolic process", "down-regulation of gamma-aminobutyric acid catabolism", "negative regulation of 4-aminobutyrate catabolic process", "down regulation of 4-aminobutyrate catabolic process", "inhibition of gamma-aminobutyric acid degradation", "inhibition of gamma-aminobutyric acid breakdown", "down-regulation of GABA catabolism", "downregulation of 4-aminobutanoate catabolism", "downregulation of 4-aminobutyrate catabolic process", "down-regulation of GABA catabolic process", "inhibition of gamma-aminobutyric acid catabolism", "down regulation of gamma-aminobutyric acid catabolism", "downregulation of gamma-aminobutyric acid degradation", "down regulation of GABA catabolic process", "downregulation of 4-aminobutyrate catabolism", "negative regulation of gamma-aminobutyric acid catabolism", "down regulation of gamma-aminobutyric acid catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of gamma-aminobutyric acid catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3547051", "aliases": ["regulation of gamma-aminobutyric acid degradation", "regulation of gamma-aminobutyric acid catabolism", "regulation of GABA catabolic process", "regulation of 4-aminobutyrate catabolism", "regulation of gamma-aminobutyric acid breakdown", "regulation of GABA catabolism", "regulation of 4-aminobutyrate catabolic process", "regulation of 4-aminobutanoate catabolic process", "regulation of 4-aminobutanoate catabolism"], "types": ["T044"], "canonical_name": "regulation of gamma-aminobutyric acid catabolic process", "definition": "Any process that modulates the frequency, rate or extent of gamma-aminobutyric acid catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3547052", "aliases": ["up regulation of urea decomposition", "activation of urea decomposition", "upregulation of urea catabolism", "up regulation of urea catabolism", "upregulation of urea degradation", "positive regulation of urea decomposition", "positive regulation of urea catabolism", "up regulation of urea catabolic process", "up-regulation of urea catabolic process", "up-regulation of urea decomposition", "upregulation of urea decomposition", "upregulation of urea catabolic process", "up regulation of urea degradation", "upregulation of urea breakdown", "up-regulation of urea catabolism", "up-regulation of urea breakdown", "positive regulation of urea degradation", "activation of urea degradation", "activation of urea breakdown", "positive regulation of urea breakdown", "up-regulation of urea degradation", "activation of urea catabolism", "up regulation of urea breakdown"], "types": ["T044"], "canonical_name": "positive regulation of urea catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of urea catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3547053", "aliases": ["downregulation of urea catabolism", "negative regulation of urea breakdown", "down-regulation of urea catabolism", "downregulation of urea degradation", "negative regulation of urea degradation", "inhibition of urea breakdown", "down-regulation of urea decomposition", "downregulation of urea decomposition", "down regulation of urea catabolic process", "down regulation of urea decomposition", "down regulation of urea catabolism", "down-regulation of urea breakdown", "down-regulation of urea degradation", "negative regulation of urea catabolism", "down-regulation of urea catabolic process", "down regulation of urea degradation", "inhibition of urea catabolism", "downregulation of urea catabolic process", "downregulation of urea breakdown", "inhibition of urea degradation", "inhibition of urea decomposition", "negative regulation of urea decomposition", "down regulation of urea breakdown"], "types": ["T044"], "canonical_name": "negative regulation of urea catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of urea catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3547054", "aliases": ["up-regulation of homoserine synthesis", "up regulation of homoserine formation", "activation of homoserine formation", "up regulation of homoserine biosynthetic process", "up-regulation of homoserine biosynthesis", "positive regulation of homoserine formation", "up-regulation of homoserine biosynthetic process", "positive regulation of homoserine synthesis", "positive regulation of homoserine anabolism", "activation of homoserine biosynthesis", "up regulation of homoserine synthesis", "up-regulation of homoserine formation", "positive regulation of homoserine biosynthesis", "up regulation of homoserine biosynthesis", "upregulation of homoserine synthesis", "up regulation of homoserine anabolism", "activation of homoserine anabolism", "activation of homoserine synthesis", "upregulation of homoserine biosynthesis", "upregulation of homoserine biosynthetic process", "up-regulation of homoserine anabolism", "upregulation of homoserine formation", "upregulation of homoserine anabolism"], "types": ["T044"], "canonical_name": "positive regulation of homoserine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of homoserine biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547055", "aliases": ["inhibition of homoserine biosynthesis", "negative regulation of homoserine anabolism", "downregulation of homoserine biosynthetic process", "down-regulation of homoserine biosynthesis", "downregulation of homoserine synthesis", "inhibition of homoserine anabolism", "down regulation of homoserine formation", "down-regulation of homoserine biosynthetic process", "negative regulation of homoserine formation", "down-regulation of homoserine formation", "down-regulation of homoserine synthesis", "down-regulation of homoserine anabolism", "downregulation of homoserine formation", "downregulation of homoserine biosynthesis", "down regulation of homoserine biosynthesis", "down regulation of homoserine synthesis", "downregulation of homoserine anabolism", "down regulation of homoserine anabolism", "inhibition of homoserine formation", "inhibition of homoserine synthesis", "down regulation of homoserine biosynthetic process", "negative regulation of homoserine synthesis", "negative regulation of homoserine biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of homoserine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of homoserine biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547056", "aliases": ["regulation of homoserine biosynthesis", "regulation of homoserine formation", "regulation of homoserine anabolism", "regulation of homoserine synthesis"], "types": ["T044"], "canonical_name": "regulation of homoserine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of homoserine biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547057", "aliases": ["(+)-larreatricin metabolism"], "types": ["T044"], "canonical_name": "(+)-larreatricin metabolic process", "definition": "The chemical reactions and pathways involving (+)-larreatricin. [GOC:TermGenie, pmid:12960376]"}
{"concept_id": "C3547058", "aliases": ["(+)-3'-hydroxylarreatricin biosynthesis", "(+)-3'-hydroxylarreatricin formation", "(+)-3'-hydroxylarreatricin synthesis", "(+)-3'-hydroxylarreatricin anabolism"], "types": ["T044"], "canonical_name": "(+)-3'-hydroxylarreatricin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (+)-3'-hydroxylarreatricin. [GOC:TermGenie, pmid:12960376]"}
{"concept_id": "C3547059", "aliases": [], "types": ["T044"], "canonical_name": "leptomycin B binding", "definition": "Binding to leptomycin B. [GOC:TermGenie]"}
{"concept_id": "C3547060", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell differentiation involved in bone development", "definition": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state. [GOC:hjd, GOC:TermGenie, PMID:21571217]"}
{"concept_id": "C3547061", "aliases": ["L-isoleucine synthesis", "L-isoleucine biosynthesis", "L-isoleucine formation", "L-isoleucine anabolism"], "types": ["T044"], "canonical_name": "L-isoleucine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-isoleucine. [GOC:TermGenie]"}
{"concept_id": "C3547062", "aliases": ["L-glutamine formation", "L-glutamine synthesis", "L-glutamine anabolism", "L-glutamine biosynthesis"], "types": ["T044"], "canonical_name": "L-glutamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-glutamine. [GOC:TermGenie]"}
{"concept_id": "C3547063", "aliases": ["establishment and maintenance of protein localization involved in auxin polar transport", "protein localisation involved in auxin polar transport"], "types": ["T043"], "canonical_name": "protein localization involved in auxin polar transport", "definition": "Any protein localization that is involved in auxin polar transport. [GOC:TermGenie, PMID:23163883]"}
{"concept_id": "C3547064", "aliases": [], "types": ["T044"], "canonical_name": "salt transmembrane transporter activity", "definition": "Enables the transfer of salt from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547065", "aliases": ["cellular response to oxygen molecular entity"], "types": ["T043"], "canonical_name": "cellular response to oxygen-containing compound", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547066", "aliases": ["response to oxygen molecular entity"], "types": ["T043"], "canonical_name": "response to oxygen-containing compound", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547067", "aliases": ["cellular response to nitrogen molecular entity"], "types": ["T043"], "canonical_name": "cellular response to nitrogen compound", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547068", "aliases": ["response to nitrogen molecular entity"], "types": ["T043"], "canonical_name": "response to nitrogen compound", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547069", "aliases": ["olivetolic acid anabolism", "olivetolic acid synthesis", "olivetolic acid biosynthesis", "olivetolic acid formation"], "types": ["T044"], "canonical_name": "olivetolic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of olivetolic acid. [GOC:TermGenie]"}
{"concept_id": "C3547070", "aliases": ["cannabinoid synthesis", "cannabinoid formation", "cannabinoid anabolism", "cannabinoid biosynthesis"], "types": ["T044"], "canonical_name": "cannabinoid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cannabinoid. [GOC:TermGenie]"}
{"concept_id": "C3547071", "aliases": ["tyramine anabolism", "tyramine biosynthesis", "tyramine synthesis", "tyramine formation"], "types": ["T044"], "canonical_name": "tyramine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tyramine. [GOC:TermGenie, PMID:21284755]"}
{"concept_id": "C3547072", "aliases": ["upregulation of compound eye retinal cell apoptotic process", "up-regulation of compound eye retinal cell apoptotic process", "up regulation of compound eye retinal cell apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of compound eye retinal cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]"}
{"concept_id": "C3547073", "aliases": ["down-regulation of compound eye retinal cell apoptotic process", "downregulation of compound eye retinal cell apoptotic process", "down regulation of compound eye retinal cell apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of compound eye retinal cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process. [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]"}
{"concept_id": "C3547074", "aliases": [], "types": ["T043"], "canonical_name": "regulation of compound eye retinal cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process. [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]"}
{"concept_id": "C3547075", "aliases": ["hydrogen ion binding"], "types": ["T044"], "canonical_name": "proton binding", "definition": "Binding to proton. [GOC:TermGenie]"}
{"concept_id": "C3547079", "aliases": ["glutathione derivative synthesis", "glutathione derivative biosynthesis", "glutathione derivative formation", "glutathione derivative anabolism"], "types": ["T044"], "canonical_name": "glutathione derivative biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glutathione derivative. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547080", "aliases": ["glutathione derivative breakdown", "glutathione derivative catabolism", "glutathione derivative degradation"], "types": ["T040"], "canonical_name": "glutathione derivative catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glutathione derivative. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547081", "aliases": ["glutathione derivative metabolism"], "types": ["T044"], "canonical_name": "glutathione derivative metabolic process", "definition": "The chemical reactions and pathways involving glutathione derivative. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547082", "aliases": [], "types": ["T044"], "canonical_name": "arsenate ion transmembrane transport", "definition": "The process in which arsenate is transported across a membrane. [GOC:TermGenie]"}
{"concept_id": "C3547083", "aliases": [], "types": ["T044"], "canonical_name": "arsenate ion transmembrane transporter activity", "definition": "Enables the transfer of an arsenate ion from one side of a membrane to the other. [GOC:TermGenie]"}
{"concept_id": "C3547084", "aliases": ["sulfur molecular entity transmembrane transporter activity"], "types": ["T044"], "canonical_name": "sulfur compound transmembrane transporter activity", "definition": "Enables the transfer of a sulfur compound from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547085", "aliases": ["sulfur molecular entity binding"], "types": ["T044"], "canonical_name": "sulfur compound binding", "definition": "Binding to a sulfur compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547086", "aliases": [], "types": ["T044"], "canonical_name": "sulfur-containing amino acid secondary active transmembrane transporter activity", "definition": "Enables the transfer of sulfur-containing amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547087", "aliases": ["nucleotide membrane transport"], "types": ["T043"], "canonical_name": "nucleotide transmembrane transport", "definition": "The directed movement of nucleotide across a membrane. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547088", "aliases": [], "types": ["T043"], "canonical_name": "iron coordination entity transport", "definition": "The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547089", "aliases": ["positive regulation of histone H3K27 acetylation", "up regulation of histone H3 acetylation at K27", "up-regulation of histone H3 acetylation at K27", "up regulation of histone H3-K27 acetylation", "upregulation of histone H3 acetylation at K27", "up regulation of histone H3K27 acetylation", "activation of histone H3 acetylation at K27", "activation of histone H3K27 acetylation", "upregulation of histone H3-K27 acetylation", "up-regulation of histone H3K27 acetylation", "positive regulation of histone H3 acetylation at K27", "up-regulation of histone H3-K27 acetylation", "upregulation of histone H3K27 acetylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K27 acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K27 acetylation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547090", "aliases": ["inhibition of histone H3 acetylation at K27", "inhibition of histone H3K27 acetylation", "downregulation of histone H3 acetylation at K27", "negative regulation of histone H3K27 acetylation", "down regulation of histone H3-K27 acetylation", "down-regulation of histone H3K27 acetylation", "down regulation of histone H3 acetylation at K27", "downregulation of histone H3K27 acetylation", "downregulation of histone H3-K27 acetylation", "down regulation of histone H3K27 acetylation", "down-regulation of histone H3-K27 acetylation", "down-regulation of histone H3 acetylation at K27", "negative regulation of histone H3 acetylation at K27"], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K27 acetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 acetylation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547091", "aliases": ["regulation of histone H3 acetylation at K27", "regulation of histone H3K27 acetylation"], "types": ["T044"], "canonical_name": "regulation of histone H3-K27 acetylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K27 acetylation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547092", "aliases": ["regulation of spindle assembly involved in mitosis"], "types": ["T043"], "canonical_name": "regulation of mitotic spindle assembly", "definition": "Any process that modulates the frequency, rate or extent of mitotic spindle assembly. [GOC:TermGenie]"}
{"concept_id": "C3547093", "aliases": ["upregulation of salicylic acid-dependent systemic resistance", "positive regulation of salicylic acid-dependent systemic resistance", "up-regulation of salicylic acid-dependent systemic resistance", "up-regulation of systemic acquired resistance", "up regulation of salicylic acid-dependent systemic resistance", "up regulation of systemic acquired resistance", "upregulation of systemic acquired resistance", "activation of salicylic acid-dependent systemic resistance"], "types": ["T040"], "canonical_name": "positive regulation of systemic acquired resistance", "definition": "Any process that activates or increases the frequency, rate or extent of systemic acquired resistance. [GOC:TermGenie]"}
{"concept_id": "C3547094", "aliases": ["regulation of poly(ADP-ribose)polymerase activity", "regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity", "regulation of poly(ADP-ribose) synthetase activity", "regulation of poly(ADP-ribose) synthase activity", "regulation of poly(adenosine diphosphate ribose) polymerase activity", "regulation of ADP-ribosyltransferase (polymerizing) activity", "regulation of NAD ADP-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "regulation of NAD+ ADP-ribosyltransferase activity", "definition": "Any process that modulates the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547095", "aliases": ["quinone formation", "quinone synthesis", "quinone cofactor biosynthesis", "quinone cofactor synthesis", "quinone cofactor anabolism", "quinone cofactor biosynthetic process", "quinone anabolism", "quinone cofactor formation", "quinone biosynthesis"], "types": ["T044"], "canonical_name": "quinone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of quinone. [GOC:mb, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547096", "aliases": ["quinone catabolism", "quinone breakdown", "quinone degradation"], "types": ["T044"], "canonical_name": "quinone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of quinone. [GOC:go_curators, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547097", "aliases": [], "types": ["T043"], "canonical_name": "calcium ion export", "definition": "The directed movement of calcium ion out of a cell or organelle. [GOC:TermGenie]"}
{"concept_id": "C3547098", "aliases": ["glycosyl compound synthesis", "glycosyl compound biosynthesis", "glycosyl compound formation", "glycosyl compound anabolism"], "types": ["T044"], "canonical_name": "glycosyl compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycosyl compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547099", "aliases": ["glycosyl compound catabolism", "glycosyl compound degradation", "glycosyl compound breakdown"], "types": ["T044"], "canonical_name": "glycosyl compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycosyl compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547100", "aliases": ["glycosyl compound metabolism"], "types": ["T044"], "canonical_name": "glycosyl compound metabolic process", "definition": "The chemical reactions and pathways involving glycosyl compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547101", "aliases": [], "types": ["T043"], "canonical_name": "glycoside transport", "definition": "The directed movement of a glycoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547102", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to ketone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547103", "aliases": [], "types": ["T043"], "canonical_name": "response to ketone", "definition": "A response that results in a state of tolerance to ketone. [GOC:mengo_curators, PMID:23356676]"}
{"concept_id": "C3547104", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to peptide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547105", "aliases": [], "types": ["T043"], "canonical_name": "response to peptide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547107", "aliases": ["regulation of contractile ring localization involved in cell cycle cytokinesis", "regulation of contractile ring localisation involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "regulation of actomyosin contractile ring localization", "definition": "Any process that modulates the frequency, rate or extent of actomyosin contractile ring localization. [GOC:TermGenie]"}
{"concept_id": "C3547108", "aliases": ["up-regulation of synoviocyte proliferation", "up regulation of synoviocyte proliferation", "upregulation of synoviocyte proliferation"], "types": ["T043"], "canonical_name": "positive regulation of synoviocyte proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of synoviocyte proliferation. [GOC:TermGenie]"}
{"concept_id": "C3547109", "aliases": ["down-regulation of synoviocyte proliferation", "downregulation of synoviocyte proliferation", "down regulation of synoviocyte proliferation"], "types": ["T043"], "canonical_name": "negative regulation of synoviocyte proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synoviocyte proliferation. [GOC:TermGenie]"}
{"concept_id": "C3547110", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synoviocyte proliferation", "definition": "Any process that modulates the frequency, rate or extent of synoviocyte proliferation. [GOC:TermGenie]"}
{"concept_id": "C3547113", "aliases": ["nucleoside membrane transport"], "types": ["T043"], "canonical_name": "nucleoside transmembrane transport", "definition": "The directed movement of nucleoside across a membrane. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547114", "aliases": [], "types": ["T044"], "canonical_name": "ITP binding", "definition": "Binding to ITP. [GOC:TermGenie]"}
{"concept_id": "C3547115", "aliases": [], "types": ["T044"], "canonical_name": "XTP binding", "definition": "Binding to XTP. [GOC:TermGenie]"}
{"concept_id": "C3547117", "aliases": ["upregulation of synaptic vesicle membrane organization", "up-regulation of synaptic vesicle membrane organisation", "up regulation of synaptic vesicle membrane organisation", "up-regulation of synaptic vesicle membrane organization", "positive regulation of synaptic vesicle membrane organisation", "upregulation of synaptic vesicle membrane organisation", "up regulation of synaptic vesicle membrane organization"], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle membrane organization", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle membrane organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547118", "aliases": ["down regulation of synaptic vesicle membrane organisation", "down regulation of synaptic vesicle membrane organization", "down-regulation of synaptic vesicle membrane organisation", "negative regulation of synaptic vesicle membrane organisation", "downregulation of synaptic vesicle membrane organisation", "down-regulation of synaptic vesicle membrane organization", "downregulation of synaptic vesicle membrane organization"], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle membrane organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle membrane organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547119", "aliases": ["regulation of synaptic vesicle membrane organisation"], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle membrane organization", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle membrane organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547120", "aliases": ["up regulation of presynaptic membrane organisation", "upregulation of presynaptic membrane organization", "upregulation of presynaptic membrane organisation", "up regulation of presynaptic membrane organization", "up-regulation of presynaptic membrane organization", "positive regulation of pre-synaptic membrane organization", "up-regulation of presynaptic membrane organisation", "positive regulation of presynaptic membrane organisation"], "types": ["T043"], "canonical_name": "positive regulation of presynaptic membrane organization", "definition": "Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547121", "aliases": ["negative regulation of pre-synaptic membrane organization", "down-regulation of presynaptic membrane organisation", "down regulation of presynaptic membrane organisation", "down-regulation of presynaptic membrane organization", "downregulation of presynaptic membrane organization", "down regulation of presynaptic membrane organization", "negative regulation of presynaptic membrane organisation", "downregulation of presynaptic membrane organisation"], "types": ["T043"], "canonical_name": "negative regulation of presynaptic membrane organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic membrane organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547122", "aliases": ["regulation of presynaptic membrane organisation", "regulation of pre-synaptic membrane organization"], "types": ["T043"], "canonical_name": "regulation of presynaptic membrane organization", "definition": "Any process that modulates the frequency, rate or extent of presynaptic membrane organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547123", "aliases": ["positive regulation of postsynaptic membrane organisation", "up-regulation of postsynaptic membrane organisation", "up-regulation of postsynaptic membrane organization", "upregulation of postsynaptic membrane organisation", "upregulation of postsynaptic membrane organization", "positive regulation of post-synaptic membrane organization", "up regulation of postsynaptic membrane organisation", "up regulation of postsynaptic membrane organization"], "types": ["T043"], "canonical_name": "positive regulation of postsynaptic membrane organization", "definition": "Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547124", "aliases": ["negative regulation of postsynaptic membrane organisation", "downregulation of postsynaptic membrane organization", "downregulation of postsynaptic membrane organisation", "down-regulation of postsynaptic membrane organisation", "negative regulation of post-synaptic membrane organization", "down regulation of postsynaptic membrane organisation", "down regulation of postsynaptic membrane organization", "down-regulation of postsynaptic membrane organization"], "types": ["T043"], "canonical_name": "negative regulation of postsynaptic membrane organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547125", "aliases": ["regulation of postsynaptic membrane organisation", "regulation of post-synaptic membrane organization"], "types": ["T043"], "canonical_name": "regulation of postsynaptic membrane organization", "definition": "Any process that modulates the frequency, rate or extent of postsynaptic membrane organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547126", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to ergosterol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ergosterol stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547127", "aliases": ["downregulation of lymphocyte chemotaxis", "down regulation of lymphocyte chemotaxis", "down-regulation of lymphocyte chemotaxis"], "types": ["T043"], "canonical_name": "negative regulation of lymphocyte chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis. [GOC:TermGenie]"}
{"concept_id": "C3547128", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lymphocyte chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. [GOC:TermGenie]"}
{"concept_id": "C3547129", "aliases": ["up regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "positive regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning", "positive regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning", "up-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "upregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "upregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "up regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning", "up-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "upregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning", "up-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning", "up regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning", "up regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "up-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning", "positive regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "upregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning"], "types": ["T044"], "canonical_name": "positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "definition": "Any process that activates or increases the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. [GOC:TermGenie]"}
{"concept_id": "C3547130", "aliases": ["down regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning", "down regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "downregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning", "downregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "down-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "down regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning", "down-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning", "downregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning", "negative regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning", "downregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "down-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning", "down regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "negative regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "down-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "negative regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning"], "types": ["T040"], "canonical_name": "negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. [GOC:TermGenie]"}
{"concept_id": "C3547131", "aliases": ["regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning", "regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning", "regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning"], "types": ["T044"], "canonical_name": "regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "definition": "Any process that modulates the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. [GOC:TermGenie]"}
{"concept_id": "C3547133", "aliases": [], "types": ["T044"], "canonical_name": "organic hydroxy compound transmembrane transporter activity", "definition": "Enables the transfer of organic hydroxy compound from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547134", "aliases": ["organic hydroxy compound anabolism", "organic hydroxy compound formation", "organic hydroxy compound biosynthesis", "organic hydroxy compound synthesis"], "types": ["T044"], "canonical_name": "organic hydroxy compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of organic hydroxy compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547135", "aliases": ["organic hydroxy compound catabolism", "organic hydroxy compound breakdown", "organic hydroxy compound degradation"], "types": ["T044"], "canonical_name": "organic hydroxy compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547136", "aliases": ["organic hydroxy compound metabolism"], "types": ["T044"], "canonical_name": "organic hydroxy compound metabolic process", "definition": "The chemical reactions and pathways involving organic hydroxy compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547137", "aliases": ["upregulation of terminal button organisation", "up-regulation of bouton organization", "upregulation of terminal button organization", "up-regulation of terminal button organisation", "up regulation of synaptic bouton organization", "positive regulation of terminal bouton organization", "upregulation of synaptic bouton organization", "up-regulation of presynaptic bouton organization", "up regulation of terminal button organisation", "upregulation of terminal bouton organization", "upregulation of presynaptic bouton organization", "up regulation of bouton organization", "up regulation of terminal button organization", "positive regulation of terminal button organisation", "positive regulation of bouton organization", "positive regulation of presynaptic bouton organization", "upregulation of bouton organization", "up-regulation of terminal button organization", "up regulation of presynaptic bouton organization", "up-regulation of terminal bouton organization", "up-regulation of synaptic bouton organization", "positive regulation of synaptic bouton organization", "up regulation of terminal bouton organization"], "types": ["T043"], "canonical_name": "positive regulation of terminal button organization", "definition": "Any process that activates or increases the frequency, rate or extent of terminal button organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547138", "aliases": ["downregulation of presynaptic bouton organization", "down regulation of terminal bouton organization", "down-regulation of terminal bouton organization", "downregulation of bouton organization", "down regulation of synaptic bouton organization", "negative regulation of bouton organization", "downregulation of terminal bouton organization", "downregulation of synaptic bouton organization", "down-regulation of presynaptic bouton organization", "downregulation of terminal button organisation", "negative regulation of presynaptic bouton organization", "down regulation of terminal button organization", "down regulation of terminal button organisation", "downregulation of terminal button organization", "down regulation of presynaptic bouton organization", "down-regulation of synaptic bouton organization", "negative regulation of terminal bouton organization", "negative regulation of synaptic bouton organization", "down-regulation of terminal button organisation", "down-regulation of bouton organization", "down-regulation of terminal button organization", "down regulation of bouton organization", "negative regulation of terminal button organisation"], "types": ["T043"], "canonical_name": "negative regulation of terminal button organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of terminal button organization. [GOC:TermGenie, PMID:22426000]"}
{"concept_id": "C3547139", "aliases": [], "types": ["T044"], "canonical_name": "cardiolipin binding", "definition": "Binding to cardiolipin. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3547140", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylglycerol binding", "definition": "Binding to phosphatidylglycerol. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3547141", "aliases": ["up-regulation of vesicle transport along microtubule", "positive regulation of microtubule-based vesicle localization", "upregulation of microtubule-based vesicle localization", "upregulation of vesicle transport along microtubule", "up regulation of vesicle transport along microtubule", "up-regulation of microtubule-based vesicle localization", "up regulation of microtubule-based vesicle localization", "activation of microtubule-based vesicle localization"], "types": ["T043"], "canonical_name": "positive regulation of vesicle transport along microtubule", "definition": "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule. [GOC:TermGenie]"}
{"concept_id": "C3547142", "aliases": ["downregulation of vesicle transport along microtubule", "down regulation of microtubule-based vesicle localization", "negative regulation of microtubule-based vesicle localization", "down-regulation of vesicle transport along microtubule", "down-regulation of microtubule-based vesicle localization", "down regulation of vesicle transport along microtubule", "downregulation of microtubule-based vesicle localization", "inhibition of microtubule-based vesicle localization"], "types": ["T043"], "canonical_name": "negative regulation of vesicle transport along microtubule", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule. [GOC:TermGenie]"}
{"concept_id": "C3547143", "aliases": ["regulation of microtubule-based vesicle localization"], "types": ["T043"], "canonical_name": "regulation of vesicle transport along microtubule", "definition": "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule. [GOC:TermGenie]"}
{"concept_id": "C3547144", "aliases": ["alpha-amino acid biosynthesis", "alpha-amino acid anabolism", "alpha-amino acid synthesis", "alpha-amino acid formation"], "types": ["T044"], "canonical_name": "alpha-amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an alpha-amino acid. [GOC:TermGenie]"}
{"concept_id": "C3547145", "aliases": ["alpha-amino acid degradation", "alpha-amino acid breakdown", "alpha-amino acid catabolism"], "types": ["T044"], "canonical_name": "alpha-amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. [GOC:TermGenie]"}
{"concept_id": "C3547146", "aliases": ["alpha-amino acid metabolism"], "types": ["T044"], "canonical_name": "alpha-amino acid metabolic process", "definition": "The chemical reactions and pathways involving an alpha-amino acid. [GOC:TermGenie]"}
{"concept_id": "C3547147", "aliases": [], "types": ["T044"], "canonical_name": "dethiobiotin transmembrane transporter activity", "definition": "Enables the transfer of dethiobiotin from one side of a membrane to the other. [GOC:TermGenie]"}
{"concept_id": "C3547149", "aliases": [], "types": ["T044"], "canonical_name": "dethiobiotin binding", "definition": "Binding to dethiobiotin. [GOC:TermGenie]"}
{"concept_id": "C3547150", "aliases": ["strigolactone synthesis", "strigolactone biosynthesis", "strigolactone formation", "strigolactone anabolism"], "types": ["T044"], "canonical_name": "strigolactone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of strigolactone. [GOC:TermGenie]"}
{"concept_id": "C3547151", "aliases": ["strigolactone metabolism"], "types": ["T044"], "canonical_name": "strigolactone metabolic process", "definition": "The chemical reactions and pathways involving strigolactone. [GOC:TermGenie]"}
{"concept_id": "C3547152", "aliases": ["(-)-pinoresinol anabolism", "(-)-pinoresinol biosynthesis", "(-)-pinoresinol synthesis", "(-)-pinoresinol formation"], "types": ["T044"], "canonical_name": "(-)-pinoresinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (-)-pinoresinol. [GOC:TermGenie]"}
{"concept_id": "C3547153", "aliases": ["(-)-pinoresinol metabolism"], "types": ["T044"], "canonical_name": "(-)-pinoresinol metabolic process", "definition": "The chemical reactions and pathways involving (-)-pinoresinol. [GOC:TermGenie]"}
{"concept_id": "C3547154", "aliases": [], "types": ["T043"], "canonical_name": "response to carbendazim", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547155", "aliases": [], "types": ["T043"], "canonical_name": "response to reversine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547156", "aliases": [], "types": ["T043"], "canonical_name": "response to hesperadin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547157", "aliases": [], "types": ["T043"], "canonical_name": "response to capsazepine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547158", "aliases": [], "types": ["T043"], "canonical_name": "response to GW 7647", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547159", "aliases": ["downregulation of double-strand break repair via break-induced replication", "down regulation of double-strand break repair via break-induced replication", "down-regulation of double-strand break repair via break-induced replication"], "types": ["T045"], "canonical_name": "negative regulation of double-strand break repair via break-induced replication", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via break-induced replication. [GOC:TermGenie]"}
{"concept_id": "C3547160", "aliases": [], "types": ["T045"], "canonical_name": "regulation of double-strand break repair via break-induced replication", "definition": "Any process that modulates the frequency, rate or extent of double-strand break repair via break-induced replication. [GOC:TermGenie]"}
{"concept_id": "C3547161", "aliases": ["microtubule fascicle of axon", "microtubule bundle of axon", "axon microtubule fascicle"], "types": ["T026"], "canonical_name": "axon microtubule bundle", "definition": "An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment. [GOC:TermGenie, NIF_Subcellular:sao707332678]"}
{"concept_id": "C3547162", "aliases": ["microtubule of dendrite", "microtubulus of dendrite"], "types": ["T026"], "canonical_name": "dendritic microtubule", "definition": "Any microtubule in a dendrite, a neuron projection. [GOC:TermGenie, NIF_Subcellular:sao110773650]"}
{"concept_id": "C3547163", "aliases": ["activation of ASIC activity", "up regulation of ASIC activity", "up-regulation of ASIC activity", "upregulation of ASIC activity", "up-regulation of acid-sensing ion channel activity", "positive regulation of ASIC activity", "upregulation of acid-sensing ion channel activity", "up regulation of acid-sensing ion channel activity"], "types": ["T038"], "canonical_name": "positive regulation of acid-sensing ion channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of acid-sensing ion channel activity. [GOC:TermGenie]"}
{"concept_id": "C3547164", "aliases": ["negative regulation of ASIC activity", "inhibition of ASIC activity", "downregulation of ASIC activity", "down-regulation of ASIC activity", "down-regulation of acid-sensing ion channel activity", "down regulation of ASIC activity", "down regulation of acid-sensing ion channel activity", "downregulation of acid-sensing ion channel activity"], "types": ["T044"], "canonical_name": "negative regulation of acid-sensing ion channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of acid-sensing ion channel activity. [GOC:TermGenie]"}
{"concept_id": "C3547165", "aliases": ["regulation of ASIC activity"], "types": ["T044"], "canonical_name": "regulation of acid-sensing ion channel activity", "definition": "Any process that modulates the frequency, rate or extent of acid-sensing ion channel activity. [GOC:TermGenie]"}
{"concept_id": "C3547166", "aliases": [], "types": ["T044"], "canonical_name": "tetrapeptide transmembrane transporter activity", "definition": "Enables the transfer of tetrapeptide from one side of a membrane to the other. [GOC:TermGenie]"}
{"concept_id": "C3547167", "aliases": ["tetrapeptide membrane transport", "tetrapeptide transmembrane transport"], "types": ["T043"], "canonical_name": "tetrapeptide import across plasma membrane", "definition": "The directed movement of a tetrapeptide from outside of a cell, across the plasma membrane and into the cytosol. [GOC:TermGenie, PMID:22226946]"}
{"concept_id": "C3547168", "aliases": ["downregulation of telomeric RNA transcription from RNA pol II promoter", "negative regulation of telomeric RNA transcription from Pol II promoter", "down-regulation of telomeric RNA transcription from RNA pol II promoter", "inhibition of telomeric RNA transcription from Pol II promoter", "down regulation of telomeric RNA transcription from Pol II promoter", "down-regulation of telomeric RNA transcription from Pol II promoter", "downregulation of telomeric RNA transcription from Pol II promoter", "down regulation of telomeric RNA transcription from RNA pol II promoter"], "types": ["T045"], "canonical_name": "negative regulation of telomeric RNA transcription from RNA pol II promoter", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter. [GOC:TermGenie]"}
{"concept_id": "C3547169", "aliases": ["regulation of telomeric RNA transcription from Pol II promoter"], "types": ["T045"], "canonical_name": "regulation of telomeric RNA transcription from RNA pol II promoter", "definition": "Any process that modulates the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter. [GOC:TermGenie]"}
{"concept_id": "C3547170", "aliases": ["down-regulation of alkane synthesis", "negative regulation of alkane anabolism", "negative regulation of alkane biosynthesis", "downregulation of alkane biosynthetic process", "negative regulation of alkane formation", "inhibition of alkane biosynthesis", "downregulation of alkane biosynthesis", "downregulation of alkane anabolism", "inhibition of alkane anabolism", "negative regulation of alkane synthesis", "down regulation of alkane anabolism", "down regulation of alkane biosynthetic process", "down-regulation of alkane formation", "down regulation of alkane synthesis", "inhibition of alkane synthesis", "downregulation of alkane formation", "inhibition of alkane formation", "down-regulation of alkane biosynthesis", "down-regulation of alkane anabolism", "down regulation of alkane formation", "downregulation of alkane synthesis", "down-regulation of alkane biosynthetic process", "down regulation of alkane biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of alkane biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of alkane biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547171", "aliases": ["regulation of alkane formation", "regulation of alkane anabolism", "regulation of alkane synthesis", "regulation of alkane biosynthesis"], "types": ["T044"], "canonical_name": "regulation of alkane biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of alkane biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547172", "aliases": ["organic substance synthesis", "organic molecular entity biosynthesis", "organic molecular entity formation", "organic substance biosynthesis", "organic molecular entity synthesis", "organic substance formation", "organic molecular entity biosynthetic process", "organic molecular entity anabolism", "organic substance anabolism"], "types": ["T044"], "canonical_name": "organic substance biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547173", "aliases": ["organic molecular entity degradation", "organic molecular entity breakdown", "organic molecular entity catabolic process", "organic substance degradation", "organic substance catabolism", "organic substance breakdown", "organic molecular entity catabolism"], "types": ["T044"], "canonical_name": "organic substance catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547174", "aliases": [], "types": ["T043"], "canonical_name": "fatty acid derivative transport", "definition": "The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547175", "aliases": ["fatty acid derivative formation", "fatty acid derivative synthesis", "fatty acid derivative anabolism", "fatty acid derivative biosynthesis"], "types": ["T044"], "canonical_name": "fatty acid derivative biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fatty acid derivative. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547176", "aliases": ["fatty acid derivative catabolism", "fatty acid derivative breakdown", "fatty acid derivative degradation"], "types": ["T044"], "canonical_name": "fatty acid derivative catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fatty acid derivative. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547177", "aliases": ["fatty acid derivative metabolism"], "types": ["T044"], "canonical_name": "fatty acid derivative metabolic process", "definition": "The chemical reactions and pathways involving fatty acid derivative. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547178", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid derivative binding", "definition": "Binding to fatty acid derivative. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547179", "aliases": ["organonitrogen compound anabolism", "organonitrogen compound formation", "organonitrogen compound synthesis", "organonitrogen compound biosynthesis"], "types": ["T044"], "canonical_name": "organonitrogen compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of organonitrogen compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547180", "aliases": ["organonitrogen compound breakdown", "organonitrogen compound degradation", "organonitrogen compound catabolism"], "types": ["T044"], "canonical_name": "organonitrogen compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547181", "aliases": ["organonitrogen compound metabolism"], "types": ["T044"], "canonical_name": "organonitrogen compound metabolic process", "definition": "The chemical reactions and pathways involving organonitrogen compound. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547182", "aliases": ["response to CPT"], "types": ["T043"], "canonical_name": "response to camptothecin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547183", "aliases": [], "types": ["T043"], "canonical_name": "response to paraquat", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547184", "aliases": [], "types": ["T043"], "canonical_name": "response to benomyl", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547185", "aliases": [], "types": ["T043"], "canonical_name": "response to purvalanol A", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547186", "aliases": [], "types": ["T043"], "canonical_name": "response to ribavirin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ribavirin stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547187", "aliases": [], "types": ["T043"], "canonical_name": "response to metformin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547188", "aliases": [], "types": ["T043"], "canonical_name": "response to fenofibrate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547189", "aliases": [], "types": ["T043"], "canonical_name": "response to candesartan", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a candesartan stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547190", "aliases": [], "types": ["T043"], "canonical_name": "response to paclitaxel", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547191", "aliases": ["response to acetaminophen"], "types": ["T043"], "canonical_name": "response to paracetamol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paracetamol stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547192", "aliases": ["malonic acid membrane transport"], "types": ["T043"], "canonical_name": "malonic acid transmembrane transport", "definition": "The directed movement of malonic acid across a membrane. [GOC:al, GOC:TermGenie]"}
{"concept_id": "C3547193", "aliases": ["up-regulation of endothelial cell development", "upregulation of endothelial cell development", "up regulation of endothelial cell development"], "types": ["T043"], "canonical_name": "positive regulation of endothelial cell development", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial cell development. [GOC:pr, GOC:TermGenie, PMID:19470579]"}
{"concept_id": "C3547194", "aliases": ["down-regulation of endothelial cell development", "downregulation of endothelial cell development", "down regulation of endothelial cell development"], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. [GOC:pr, GOC:TermGenie, PMID:19470579]"}
{"concept_id": "C3547195", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelial cell development", "definition": "Any process that modulates the frequency, rate or extent of endothelial cell development. [GOC:pr, GOC:TermGenie, PMID:19470579]"}
{"concept_id": "C3547197", "aliases": ["positive regulation of synaptic vesicle lumen pH reduction", "up-regulation of synaptic vesicle lumen pH reduction", "positive regulation of proton loading", "upregulation of synaptic vesicle lumen pH reduction", "upregulation of synaptic vesicle lumen acidification", "up regulation of synaptic vesicle lumen pH reduction", "up-regulation of synaptic vesicle lumen acidification", "up regulation of synaptic vesicle lumen acidification"], "types": ["T039"], "canonical_name": "positive regulation of synaptic vesicle lumen acidification", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle lumen acidification. [GOC:TermGenie]"}
{"concept_id": "C3547198", "aliases": ["down-regulation of synaptic vesicle lumen acidification", "negative regulation of synaptic vesicle lumen pH reduction", "down-regulation of synaptic vesicle lumen pH reduction", "downregulation of synaptic vesicle lumen pH reduction", "negative regulation of proton loading", "down regulation of synaptic vesicle lumen pH reduction", "down regulation of synaptic vesicle lumen acidification", "downregulation of synaptic vesicle lumen acidification"], "types": ["T039"], "canonical_name": "negative regulation of synaptic vesicle lumen acidification", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle lumen acidification. [GOC:TermGenie]"}
{"concept_id": "C3547199", "aliases": ["regulation of synaptic vesicle lumen pH reduction", "regulation of synaptic vesicle lumen proton loading"], "types": ["T039"], "canonical_name": "regulation of synaptic vesicle lumen acidification", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification. [GOC:TermGenie]"}
{"concept_id": "C3547200", "aliases": [], "types": ["T043"], "canonical_name": "response to raffinose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547201", "aliases": ["positive regulation of ent-pimara-8(14),15-diene synthesis", "up-regulation of ent-pimara-8(14),15-diene biosynthesis", "positive regulation of ent-pimara-8(14),15-diene formation", "up-regulation of ent-pimara-8(14),15-diene formation", "positive regulation of ent-pimara-8(14),15-diene biosynthesis", "up regulation of ent-pimara-8(14),15-diene synthesis", "upregulation of ent-pimara-8(14),15-diene biosynthesis", "up regulation of ent-pimara-8(14),15-diene anabolism", "up-regulation of ent-pimara-8(14),15-diene biosynthetic process", "upregulation of ent-pimara-8(14),15-diene synthesis", "upregulation of ent-pimara-8(14),15-diene anabolism", "up regulation of ent-pimara-8(14),15-diene biosynthesis", "up-regulation of ent-pimara-8(14),15-diene anabolism", "up-regulation of ent-pimara-8(14),15-diene synthesis", "up regulation of ent-pimara-8(14),15-diene biosynthetic process", "positive regulation of ent-pimara-8(14),15-diene anabolism", "upregulation of ent-pimara-8(14),15-diene biosynthetic process", "upregulation of ent-pimara-8(14),15-diene formation", "up regulation of ent-pimara-8(14),15-diene formation"], "types": ["T044"], "canonical_name": "positive regulation of ent-pimara-8(14),15-diene biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547202", "aliases": ["down regulation of ent-pimara-8(14),15-diene biosynthetic process", "negative regulation of ent-pimara-8(14),15-diene anabolism", "down regulation of ent-pimara-8(14),15-diene formation", "down-regulation of ent-pimara-8(14),15-diene biosynthesis", "down regulation of ent-pimara-8(14),15-diene anabolism", "down regulation of ent-pimara-8(14),15-diene biosynthesis", "negative regulation of ent-pimara-8(14),15-diene formation", "negative regulation of ent-pimara-8(14),15-diene synthesis", "negative regulation of ent-pimara-8(14),15-diene biosynthesis", "down regulation of ent-pimara-8(14),15-diene synthesis", "downregulation of ent-pimara-8(14),15-diene formation", "down-regulation of ent-pimara-8(14),15-diene biosynthetic process", "down-regulation of ent-pimara-8(14),15-diene formation", "downregulation of ent-pimara-8(14),15-diene synthesis", "down-regulation of ent-pimara-8(14),15-diene anabolism", "downregulation of ent-pimara-8(14),15-diene anabolism", "downregulation of ent-pimara-8(14),15-diene biosynthesis", "down-regulation of ent-pimara-8(14),15-diene synthesis", "downregulation of ent-pimara-8(14),15-diene biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of ent-pimara-8(14),15-diene biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547203", "aliases": ["regulation of ent-pimara-8(14),15-diene synthesis", "regulation of ent-pimara-8(14),15-diene biosynthesis", "regulation of ent-pimara-8(14),15-diene formation", "regulation of ent-pimara-8(14),15-diene anabolism"], "types": ["T043"], "canonical_name": "regulation of ent-pimara-8(14),15-diene biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547204", "aliases": ["ent-pimara-8(14),15-diene synthesis", "ent-pimara-8(14),15-diene formation", "ent-pimara-8(14),15-diene biosynthesis", "ent-pimara-8(14),15-diene anabolism"], "types": ["T044"], "canonical_name": "ent-pimara-8(14),15-diene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ent-pimara-8(14),15-diene. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547205", "aliases": ["ent-pimara-8(14),15-diene degradation", "ent-pimara-8(14),15-diene catabolism", "ent-pimara-8(14),15-diene breakdown"], "types": ["T044"], "canonical_name": "ent-pimara-8(14),15-diene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ent-pimara-8(14),15-diene. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547206", "aliases": ["ent-pimara-8(14),15-diene metabolism"], "types": ["T044"], "canonical_name": "ent-pimara-8(14),15-diene metabolic process", "definition": "The chemical reactions and pathways involving ent-pimara-8(14),15-diene. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547207", "aliases": ["up regulation of DNA demethylation", "up-regulation of DNA demethylation", "upregulation of DNA demethylation"], "types": ["T045"], "canonical_name": "positive regulation of DNA demethylation", "definition": "Any process that activates or increases the frequency, rate or extent of DNA demethylation. [GOC:TermGenie]"}
{"concept_id": "C3547208", "aliases": ["down-regulation of DNA demethylation", "downregulation of DNA demethylation", "down regulation of DNA demethylation"], "types": ["T045"], "canonical_name": "negative regulation of DNA demethylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA demethylation. [GOC:TermGenie]"}
{"concept_id": "C3547209", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA demethylation", "definition": "Any process that modulates the frequency, rate or extent of DNA demethylation. [GOC:TermGenie]"}
{"concept_id": "C3547210", "aliases": ["regulation of hemopoietic progenitor cell differentiation", "regulation of haematopoietic progenitor cell differentiation", "regulation of haemopoietic progenitor cell differentiation"], "types": ["T038"], "canonical_name": "regulation of hematopoietic progenitor cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. [GOC:BHF, GOC:rl, GOC:TermGenie]"}
{"concept_id": "C3547211", "aliases": [], "types": ["T044"], "canonical_name": "hypochlorite binding", "definition": "Binding to hypochlorite. [GOC:pr, GOC:TermGenie, PMID:22223481]"}
{"concept_id": "C3547212", "aliases": [], "types": ["T043"], "canonical_name": "response to hypochlorite", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hypochlorite stimulus. [GOC:pr, GOC:TermGenie, PMID:22223481]"}
{"concept_id": "C3547213", "aliases": ["upregulation of anion channel activity", "up regulation of anion channel activity", "up-regulation of anion channel activity"], "types": ["T039"], "canonical_name": "positive regulation of anion channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of anion channel activity. [GOC:TermGenie]"}
{"concept_id": "C3547214", "aliases": ["H2O2 mediated signaling pathway involved in stomatal movement", "hydrogen peroxide mediated signalling pathway involved in stomatal movement"], "types": ["T044"], "canonical_name": "hydrogen peroxide mediated signaling pathway involved in stomatal movement", "definition": "Any hydrogen peroxide mediated signaling pathway that is involved in stomatal movement. [GOC:TermGenie]"}
{"concept_id": "C3547215", "aliases": ["abscisic acid mediated signaling pathway involved in stomatal movement", "abscisic acid mediated signalling involved in stomatal movement"], "types": ["T044"], "canonical_name": "abscisic acid-activated signaling pathway involved in stomatal movement", "definition": "Any abscisic acid mediated signaling pathway that is involved in stomatal movement. [GOC:TermGenie, PMID:22730405]"}
{"concept_id": "C3547216", "aliases": ["up regulation of macromitophagy", "up-regulation of macromitophagy", "positive regulation of macromitophagy", "upregulation of macromitophagy"], "types": ["T043"], "canonical_name": "positive regulation of mitophagy", "definition": "Any process that activates or increases the frequency, rate or extent of mitophagy. [GOC:TermGenie]"}
{"concept_id": "C3547217", "aliases": ["negative regulation of macromitophagy", "down-regulation of macromitophagy", "downregulation of macromitophagy", "down regulation of macromitophagy"], "types": ["T043"], "canonical_name": "negative regulation of mitophagy", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy. [GOC:TermGenie]"}
{"concept_id": "C3547218", "aliases": ["regulation of macromitophagy"], "types": ["T043"], "canonical_name": "regulation of mitophagy", "definition": "Any process that modulates the frequency, rate or extent of macromitophagy. [GOC:TermGenie]"}
{"concept_id": "C3547219", "aliases": ["stimulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus", "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus", "upregulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus", "positive regulation of transcription from Pol II promoter involved in cellular response to chemical stimulus", "up regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus", "definition": "Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus. [GOC:TermGenie, PMID:22840777]"}
{"concept_id": "C3547220", "aliases": ["aspyridone B synthesis", "aspyridone B anabolism", "aspyridone B formation", "aspyridone B biosynthesis"], "types": ["T044"], "canonical_name": "aspyridone B biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aspyridone B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547221", "aliases": ["aspyridone B degradation", "aspyridone B breakdown", "aspyridone B catabolism"], "types": ["T044"], "canonical_name": "aspyridone B catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aspyridone B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547222", "aliases": ["aspyridone B metabolism"], "types": ["T044"], "canonical_name": "aspyridone B metabolic process", "definition": "The chemical reactions and pathways involving aspyridone B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547223", "aliases": ["aspyridone A anabolism", "aspyridone A formation", "aspyridone A synthesis", "aspyridone A biosynthesis"], "types": ["T044"], "canonical_name": "aspyridone A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aspyridone A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547224", "aliases": ["aspyridone A degradation", "aspyridone A breakdown", "aspyridone A catabolism"], "types": ["T044"], "canonical_name": "aspyridone A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of aspyridone A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547225", "aliases": ["aspyridone A metabolism"], "types": ["T044"], "canonical_name": "aspyridone A metabolic process", "definition": "The chemical reactions and pathways involving aspyridone A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547226", "aliases": [], "types": ["T044"], "canonical_name": "poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity", "definition": "Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other. [GOC:TermGenie, PMID:15090514, PMID:18359807]"}
{"concept_id": "C3547227", "aliases": [], "types": ["T044"], "canonical_name": "lipo-chitin oligosaccharide transmembrane-transporting ATPase activity"}
{"concept_id": "C3547228", "aliases": [], "types": ["T044"], "canonical_name": "lipo-chitin oligosaccharide transmembrane transporter activity", "definition": "Enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other. [GOC:TermGenie]"}
{"concept_id": "C3547229", "aliases": ["(-)-microperfuranone synthesis", "(-)-microperfuranone anabolism", "(-)-microperfuranone biosynthesis", "(-)-microperfuranone formation"], "types": ["T044"], "canonical_name": "(-)-microperfuranone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (-)-microperfuranone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547230", "aliases": ["(-)-microperfuranone breakdown", "(-)-microperfuranone catabolism", "(-)-microperfuranone degradation"], "types": ["T044"], "canonical_name": "(-)-microperfuranone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (-)-microperfuranone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547231", "aliases": ["(-)-microperfuranone metabolism"], "types": ["T044"], "canonical_name": "(-)-microperfuranone metabolic process", "definition": "The chemical reactions and pathways involving (-)-microperfuranone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547232", "aliases": [], "types": ["T039"], "canonical_name": "regulation of endothelial tube morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. [GOC:dph, GOC:TermGenie]"}
{"concept_id": "C3547233", "aliases": ["upregulation of glyceride transport", "up-regulation of acylglycerol transport", "positive regulation of glyceride transport", "up-regulation of glyceride transport", "up regulation of glyceride transport", "upregulation of acylglycerol transport", "up regulation of acylglycerol transport"], "types": ["T044"], "canonical_name": "positive regulation of acylglycerol transport", "definition": "Any process that activates or increases the frequency, rate or extent of acylglycerol transport. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3547234", "aliases": ["down regulation of acylglycerol transport", "down-regulation of glyceride transport", "negative regulation of glyceride transport", "down-regulation of acylglycerol transport", "downregulation of glyceride transport", "down regulation of glyceride transport", "downregulation of acylglycerol transport"], "types": ["T044"], "canonical_name": "negative regulation of acylglycerol transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of acylglycerol transport. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3547235", "aliases": ["regulation of glyceride transport"], "types": ["T044"], "canonical_name": "regulation of acylglycerol transport", "definition": "Any process that modulates the frequency, rate or extent of acylglycerol transport. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3547236", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate derivative transporter activity"}
{"concept_id": "C3547237", "aliases": [], "types": ["T043"], "canonical_name": "triazole transport", "definition": "The directed movement of a triazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547238", "aliases": ["ether formation", "ether biosynthesis", "ether synthesis", "ether anabolism"], "types": ["T044"], "canonical_name": "ether biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ether. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547239", "aliases": ["ether breakdown", "ether catabolism", "ether degradation"], "types": ["T044"], "canonical_name": "ether catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ether. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547240", "aliases": [], "types": ["T043"], "canonical_name": "response to xylene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xylene stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547241", "aliases": [], "types": ["T043"], "canonical_name": "response to p-xylene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a p-xylene stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547242", "aliases": [], "types": ["T043"], "canonical_name": "response to hexane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexane stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547243", "aliases": [], "types": ["T043"], "canonical_name": "response to tetralin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetralin stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547244", "aliases": [], "types": ["T043"], "canonical_name": "response to diphenyl ether", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenyl ether stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547245", "aliases": ["up regulation of cysteine metabolism", "upregulation of cysteine metabolic process", "up-regulation of cysteine metabolic process", "up regulation of cysteine metabolic process", "upregulation of cysteine metabolism", "positive regulation of cysteine metabolism", "up-regulation of cysteine metabolism"], "types": ["T044"], "canonical_name": "positive regulation of cysteine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cysteine metabolic process. [GOC:TermGenie]"}
{"concept_id": "C3547246", "aliases": ["down-regulation of cysteine metabolism", "downregulation of cysteine metabolism", "negative regulation of cysteine metabolism", "down-regulation of cysteine metabolic process", "down regulation of cysteine metabolism", "downregulation of cysteine metabolic process", "down regulation of cysteine metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of cysteine metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine metabolic process. [GOC:TermGenie]"}
{"concept_id": "C3547247", "aliases": ["regulation of cysteine metabolism"], "types": ["T044"], "canonical_name": "regulation of cysteine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of cysteine metabolic process. [GOC:TermGenie]"}
{"concept_id": "C3547248", "aliases": [], "types": ["T043"], "canonical_name": "response to decalin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decalin stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547249", "aliases": ["upregulation of lymphangiogenesis", "upregulation of lymph vessel formation", "up regulation of lymph vessel formation", "up regulation of lymphangiogenesis", "up-regulation of lymphangiogenesis", "up-regulation of lymph vessel formation", "positive regulation of lymph vessel formation"], "types": ["T039"], "canonical_name": "positive regulation of lymphangiogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of lymphangiogenesis. [GOC:dph, GOC:TermGenie, PMID:20133819]"}
{"concept_id": "C3547250", "aliases": ["down regulation of lymph vessel formation", "negative regulation of lymph vessel formation", "down-regulation of lymph vessel formation", "downregulation of lymph vessel formation", "downregulation of lymphangiogenesis", "down regulation of lymphangiogenesis", "down-regulation of lymphangiogenesis"], "types": ["T039"], "canonical_name": "negative regulation of lymphangiogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis. [GOC:dph, GOC:TermGenie, PMID:20133819]"}
{"concept_id": "C3547251", "aliases": ["regulation of lymph vessel formation"], "types": ["T039"], "canonical_name": "regulation of lymphangiogenesis", "definition": "Any process that modulates the frequency, rate or extent of lymphangiogenesis. [GOC:dph, GOC:TermGenie, PMID:20133819]"}
{"concept_id": "C3547256", "aliases": ["up regulation of transcription factor degradation", "positive regulation of proteasome-mediated transcription factor catabolism", "upregulation of transcription factor breakdown", "up regulation of sequence-specific DNA binding transcription factor catabolic process", "up-regulation of proteasome-mediated transcription factor catabolism", "upregulation of transcription factor catabolic process", "activation of transcription factor catabolism", "positive regulation of sequence-specific DNA binding transcription factor catabolic process", "upregulation of proteasome-mediated transcription factor catabolism", "up regulation of transcription factor breakdown", "up regulation of transcription factor catabolism", "upregulation of sequence-specific DNA binding transcription factor catabolic process", "up-regulation of sequence-specific DNA binding transcription factor catabolic process", "activation of transcription factor degradation", "activation of proteasome-mediated transcription factor catabolism", "positive regulation of transcription factor degradation", "positive regulation of transcription factor breakdown", "up regulation of proteasome-mediated transcription factor catabolism", "activation of sequence-specific DNA binding transcription factor catabolic process", "positive regulation of transcription factor catabolism", "up-regulation of transcription factor catabolism", "up regulation of transcription factor catabolic process", "activation of transcription factor breakdown", "up-regulation of transcription factor degradation", "upregulation of transcription factor degradation", "up-regulation of transcription factor catabolic process", "upregulation of transcription factor catabolism", "up-regulation of transcription factor breakdown"], "types": ["T045"], "canonical_name": "positive regulation of transcription factor catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of transcription factor catabolic process. [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559]"}
{"concept_id": "C3547257", "aliases": ["downregulation of proteasome-mediated transcription factor catabolism", "down regulation of transcription factor catabolic process", "downregulation of sequence-specific DNA binding transcription factor catabolic process", "down regulation of transcription factor breakdown", "downregulation of transcription factor catabolism", "down-regulation of transcription factor breakdown", "down regulation of transcription factor catabolism", "inhibition of transcription factor degradation", "down regulation of proteasome-mediated transcription factor catabolism", "negative regulation of sequence-specific DNA binding transcription factor catabolic process", "down-regulation of transcription factor degradation", "inhibition of proteasome-mediated transcription factor catabolism", "down-regulation of proteasome-mediated transcription factor catabolism", "inhibition of sequence-specific DNA binding transcription factor catabolic process", "downregulation of transcription factor degradation", "downregulation of transcription factor breakdown", "inhibition of transcription factor breakdown", "down regulation of transcription factor degradation", "negative regulation of proteasome-mediated transcription factor catabolism", "negative regulation of transcription factor breakdown", "negative regulation of transcription factor degradation", "down-regulation of transcription factor catabolic process", "down-regulation of transcription factor catabolism", "downregulation of transcription factor catabolic process", "inhibition of transcription factor catabolism", "down regulation of sequence-specific DNA binding transcription factor catabolic process", "down-regulation of sequence-specific DNA binding transcription factor catabolic process", "negative regulation of transcription factor catabolism"], "types": ["T045"], "canonical_name": "negative regulation of transcription factor catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transcription factor catabolic process. [GOC:al, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3547258", "aliases": ["regulation of transcription factor catabolism", "regulation of transcription factor breakdown", "regulation of proteasome-mediated transcription factor catabolism", "regulation of transcription factor degradation", "regulation of sequence-specific DNA binding transcription factor catabolic process"], "types": ["T045"], "canonical_name": "regulation of transcription factor catabolic process", "definition": "Any process that modulates the frequency, rate or extent of transcription factor catabolic process. [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559]"}
{"concept_id": "C3547259", "aliases": [], "types": ["T043"], "canonical_name": "L-lysine import into vacuole involved in cellular response to nitrogen starvation", "definition": "A L-lysine import into the vacuole that is involved in cellular response to nitrogen starvation. [GOC:TermGenie]"}
{"concept_id": "C3547260", "aliases": ["L-glutamate uptake involved in cellular response to nitrogen starvation"], "types": ["T043"], "canonical_name": "L-glutamate import involved in cellular response to nitrogen starvation", "definition": "Any L-glutamate import that is involved in cellular response to nitrogen starvation. [GOC:TermGenie]"}
{"concept_id": "C3547261", "aliases": [], "types": ["T044"], "canonical_name": "oleate transporter activity"}
{"concept_id": "C3547262", "aliases": [], "types": ["T044"], "canonical_name": "benomyl transmembrane transporter activity", "definition": "Enables the transfer of benomyl from one side of a membrane to the other. [GOC:TermGenie]"}
{"concept_id": "C3547263", "aliases": [], "types": ["T044"], "canonical_name": "aminotriazole transmembrane transporter activity", "definition": "Enables the transfer of amitrole from one side of a membrane to the other. [GOC:TermGenie]"}
{"concept_id": "C3547264", "aliases": ["benomyl membrane transport"], "types": ["T043"], "canonical_name": "benomyl transmembrane transport", "definition": "The directed movement of benomyl across a membrane. [GOC:TermGenie]"}
{"concept_id": "C3547265", "aliases": ["pyruvate membrane transport"], "types": ["T044"], "canonical_name": "pyruvate transmembrane transport", "definition": "The directed movement of pyruvate across a membrane. [GOC:TermGenie]"}
{"concept_id": "C3547266", "aliases": [], "types": ["T044"], "canonical_name": "azole transmembrane transporter activity", "definition": "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other. [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]"}
{"concept_id": "C3547267", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Golgi calcium ion export", "definition": "Any process that modulates the frequency, rate or extent of Golgi calcium ion export. [GOC:TermGenie]"}
{"concept_id": "C3547268", "aliases": ["upregulation of S-lignin catabolic process", "activation of S-lignin catabolic process", "positive regulation of S-lignin catabolic process", "activation of syringal lignin catabolism", "upregulation of syringal lignin catabolism", "upregulation of syringal lignin breakdown", "activation of syringal lignin degradation", "positive regulation of syringal lignin degradation", "up-regulation of S-lignin catabolic process", "upregulation of syringal lignin catabolic process", "up regulation of S-lignin catabolic process", "up-regulation of syringal lignin catabolism", "upregulation of syringal lignin degradation", "up regulation of syringal lignin breakdown", "up regulation of syringal lignin degradation", "activation of syringal lignin breakdown", "up regulation of syringal lignin catabolism", "up-regulation of syringal lignin degradation", "up-regulation of syringal lignin catabolic process", "positive regulation of syringal lignin catabolism", "positive regulation of syringal lignin breakdown", "up-regulation of syringal lignin breakdown", "up regulation of syringal lignin catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of syringal lignin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of syringal lignin catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547269", "aliases": ["down-regulation of syringal lignin degradation", "negative regulation of syringal lignin catabolism", "down-regulation of syringal lignin catabolic process", "down-regulation of syringal lignin catabolism", "down regulation of syringal lignin catabolism", "downregulation of syringal lignin catabolism", "down regulation of syringal lignin breakdown", "inhibition of syringal lignin breakdown", "downregulation of syringal lignin breakdown", "downregulation of syringal lignin catabolic process", "inhibition of S-lignin catabolic process", "negative regulation of syringal lignin degradation", "downregulation of S-lignin catabolic process", "down regulation of syringal lignin catabolic process", "down-regulation of syringal lignin breakdown", "down-regulation of S-lignin catabolic process", "inhibition of syringal lignin catabolism", "down regulation of S-lignin catabolic process", "inhibition of syringal lignin degradation", "down regulation of syringal lignin degradation", "negative regulation of S-lignin catabolic process", "negative regulation of syringal lignin breakdown", "downregulation of syringal lignin degradation"], "types": ["T044"], "canonical_name": "negative regulation of syringal lignin catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547270", "aliases": ["regulation of S-lignin catabolic process", "regulation of syringal lignin breakdown", "regulation of syringal lignin catabolism", "regulation of syringal lignin degradation"], "types": ["T044"], "canonical_name": "regulation of syringal lignin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of syringal lignin catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547271", "aliases": ["down regulation of ferulate catabolic process", "inhibition of ferulate catabolism", "inhibition of ferulate degradation", "downregulation of ferulate degradation", "down-regulation of ferulate breakdown", "down-regulation of ferulate catabolism", "down-regulation of ferulate catabolic process", "negative regulation of ferulate catabolism", "downregulation of ferulate breakdown", "negative regulation of ferulate degradation", "downregulation of ferulate catabolic process", "down-regulation of ferulate degradation", "negative regulation of ferulate breakdown", "down regulation of ferulate catabolism", "down regulation of ferulate degradation", "downregulation of ferulate catabolism", "down regulation of ferulate breakdown", "inhibition of ferulate breakdown"], "types": ["T044"], "canonical_name": "negative regulation of ferulate catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ferulate catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547272", "aliases": ["regulation of ferulate catabolism", "regulation of ferulate degradation", "regulation of ferulate breakdown"], "types": ["T044"], "canonical_name": "regulation of ferulate catabolic process", "definition": "Any process that modulates the frequency, rate or extent of ferulate catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547273", "aliases": ["negative regulation of tetrapyrrole anabolism", "down-regulation of tetrapyrrole anabolism", "down regulation of tetrapyrrole biosynthesis", "down regulation of tetrapyrrole formation", "negative regulation of tetrapyrrole synthesis", "down regulation of tetrapyrrole synthesis", "negative regulation of tetrapyrrole formation", "down-regulation of tetrapyrrole formation", "down-regulation of tetrapyrrole biosynthesis", "down regulation of tetrapyrrole biosynthetic process", "downregulation of tetrapyrrole anabolism", "downregulation of tetrapyrrole synthesis", "inhibition of tetrapyrrole biosynthesis", "downregulation of tetrapyrrole biosynthetic process", "down-regulation of tetrapyrrole synthesis", "down-regulation of tetrapyrrole biosynthetic process", "inhibition of tetrapyrrole formation", "inhibition of tetrapyrrole synthesis", "inhibition of tetrapyrrole anabolism", "negative regulation of tetrapyrrole biosynthesis", "downregulation of tetrapyrrole formation", "down regulation of tetrapyrrole anabolism", "downregulation of tetrapyrrole biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of tetrapyrrole biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547274", "aliases": ["regulation of tetrapyrrole biosynthesis", "regulation of tetrapyrrole synthesis", "regulation of tetrapyrrole anabolism", "regulation of tetrapyrrole formation"], "types": ["T044"], "canonical_name": "regulation of tetrapyrrole biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547275", "aliases": ["up regulation of response to formic acid", "upregulation of response to formic acid", "up-regulation of response to formic acid"], "types": ["T044"], "canonical_name": "positive regulation of response to formic acid", "definition": "Any process that activates or increases the frequency, rate or extent of response to formic acid. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547276", "aliases": ["down-regulation of response to formic acid", "downregulation of response to formic acid", "down regulation of response to formic acid"], "types": ["T038"], "canonical_name": "negative regulation of response to formic acid", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to formic acid. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547277", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to formic acid", "definition": "Any process that modulates the frequency, rate or extent of response to formic acid. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547278", "aliases": ["upregulation of response to acetate", "up-regulation of response to acetate", "up regulation of response to acetate"], "types": ["T044"], "canonical_name": "positive regulation of response to acetate", "definition": "Any process that activates or increases the frequency, rate or extent of response to acetate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547279", "aliases": ["down regulation of response to acetate", "downregulation of response to acetate", "down-regulation of response to acetate"], "types": ["T038"], "canonical_name": "negative regulation of response to acetate", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547280", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to acetate", "definition": "Any process that modulates the frequency, rate or extent of response to acetate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547281", "aliases": ["up regulation of response to toluene", "up-regulation of response to toluene", "upregulation of response to toluene"], "types": ["T044"], "canonical_name": "positive regulation of response to toluene", "definition": "Any process that activates or increases the frequency, rate or extent of response to toluene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547282", "aliases": ["down-regulation of response to toluene", "down regulation of response to toluene", "downregulation of response to toluene"], "types": ["T038"], "canonical_name": "negative regulation of response to toluene", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to toluene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547283", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to toluene", "definition": "Any process that modulates the frequency, rate or extent of response to toluene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547284", "aliases": ["up-regulation of response to benzene", "upregulation of response to benzene", "up regulation of response to benzene"], "types": ["T044"], "canonical_name": "positive regulation of response to benzene", "definition": "Any process that activates or increases the frequency, rate or extent of response to benzene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547285", "aliases": ["downregulation of response to benzene", "down regulation of response to benzene", "down-regulation of response to benzene"], "types": ["T038"], "canonical_name": "negative regulation of response to benzene", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to benzene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547286", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to benzene", "definition": "Any process that modulates the frequency, rate or extent of response to benzene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547287", "aliases": ["up regulation of response to butan-1-ol", "upregulation of response to butan-1-ol", "up-regulation of response to butan-1-ol"], "types": ["T044"], "canonical_name": "positive regulation of response to butan-1-ol", "definition": "Any process that activates or increases the frequency, rate or extent of response to butan-1-ol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547288", "aliases": ["downregulation of response to butan-1-ol", "down regulation of response to butan-1-ol", "down-regulation of response to butan-1-ol"], "types": ["T038"], "canonical_name": "negative regulation of response to butan-1-ol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to butan-1-ol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547289", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to butan-1-ol", "definition": "Any process that modulates the frequency, rate or extent of response to butan-1-ol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547290", "aliases": ["up regulation of response to propan-1-ol", "up-regulation of response to propan-1-ol", "upregulation of response to propan-1-ol"], "types": ["T044"], "canonical_name": "positive regulation of response to propan-1-ol", "definition": "Any process that activates or increases the frequency, rate or extent of response to propan-1-ol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547291", "aliases": ["downregulation of response to propan-1-ol", "down regulation of response to propan-1-ol", "down-regulation of response to propan-1-ol"], "types": ["T038"], "canonical_name": "negative regulation of response to propan-1-ol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to propan-1-ol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547292", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to propan-1-ol", "definition": "Any process that modulates the frequency, rate or extent of response to propan-1-ol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547293", "aliases": ["upregulation of response to furfural", "up-regulation of response to furfural", "up regulation of response to furfural"], "types": ["T044"], "canonical_name": "positive regulation of response to furfural", "definition": "Any process that activates or increases the frequency, rate or extent of response to furfural. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547294", "aliases": ["down regulation of response to furfural", "downregulation of response to furfural", "down-regulation of response to furfural"], "types": ["T038"], "canonical_name": "negative regulation of response to furfural", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to furfural. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547295", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to furfural", "definition": "Any process that modulates the frequency, rate or extent of response to furfural. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547296", "aliases": ["poly(hydroxyalkanoate) biosynthesis", "poly(hydroxyalkanoate) formation", "poly(hydroxyalkanoate) synthesis", "poly(hydroxyalkanoate) anabolism"], "types": ["T044"], "canonical_name": "poly(hydroxyalkanoate) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate). [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547297", "aliases": ["poly(hydroxyalkanoate) metabolism"], "types": ["T044"], "canonical_name": "poly(hydroxyalkanoate) metabolic process", "definition": "The chemical reactions and pathways involving poly(hydroxyalkanoate). [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547298", "aliases": ["activation of methylbenzene metabolic process", "up regulation of toluene metabolism", "up regulation of methylbenzene metabolic process", "activation of toluene metabolism", "upregulation of toluene metabolic process", "positive regulation of methylbenzene metabolism", "up-regulation of methylbenzene metabolism", "upregulation of toluene metabolism", "up-regulation of toluene metabolic process", "up-regulation of methylbenzene metabolic process", "positive regulation of methylbenzene metabolic process", "activation of methylbenzene metabolism", "up regulation of methylbenzene metabolism", "positive regulation of toluene metabolism", "upregulation of methylbenzene metabolism", "upregulation of methylbenzene metabolic process", "up regulation of toluene metabolic process", "up-regulation of toluene metabolism"], "types": ["T044"], "canonical_name": "positive regulation of toluene metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of toluene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547299", "aliases": ["down-regulation of methylbenzene metabolism", "down-regulation of toluene metabolic process", "downregulation of methylbenzene metabolism", "down regulation of methylbenzene metabolism", "downregulation of toluene metabolism", "negative regulation of toluene metabolism", "inhibition of methylbenzene metabolic process", "down-regulation of methylbenzene metabolic process", "negative regulation of methylbenzene metabolic process", "down regulation of toluene metabolism", "downregulation of toluene metabolic process", "down-regulation of toluene metabolism", "inhibition of methylbenzene metabolism", "inhibition of toluene metabolism", "down regulation of methylbenzene metabolic process", "down regulation of toluene metabolic process", "negative regulation of methylbenzene metabolism", "downregulation of methylbenzene metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of toluene metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of toluene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547300", "aliases": ["regulation of methylbenzene metabolism", "regulation of methylbenzene metabolic process", "regulation of toluene metabolism"], "types": ["T044"], "canonical_name": "regulation of toluene metabolic process", "definition": "Any process that modulates the frequency, rate or extent of toluene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547301", "aliases": ["activation of toluene catabolism", "upregulation of toluene breakdown", "up regulation of toluene breakdown", "upregulation of toluene catabolic process", "up-regulation of toluene catabolism", "activation of toluene breakdown", "up-regulation of toluene degradation", "positive regulation of toluene degradation", "activation of toluene degradation", "up regulation of toluene catabolism", "upregulation of toluene degradation", "up-regulation of toluene breakdown", "up regulation of toluene catabolic process", "positive regulation of toluene catabolism", "upregulation of toluene catabolism", "up regulation of toluene degradation", "up-regulation of toluene catabolic process", "positive regulation of toluene breakdown"], "types": ["T044"], "canonical_name": "positive regulation of toluene catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of toluene catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547302", "aliases": ["negative regulation of toluene degradation", "downregulation of toluene catabolism", "down regulation of toluene catabolic process", "down-regulation of toluene catabolism", "down-regulation of toluene degradation", "down-regulation of toluene catabolic process", "inhibition of toluene catabolism", "down-regulation of toluene breakdown", "downregulation of toluene catabolic process", "down regulation of toluene catabolism", "inhibition of toluene degradation", "down regulation of toluene degradation", "negative regulation of toluene catabolism", "down regulation of toluene breakdown", "inhibition of toluene breakdown", "downregulation of toluene breakdown", "downregulation of toluene degradation", "negative regulation of toluene breakdown"], "types": ["T044"], "canonical_name": "negative regulation of toluene catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of toluene catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547303", "aliases": ["regulation of toluene catabolism", "regulation of toluene degradation", "regulation of toluene breakdown"], "types": ["T044"], "canonical_name": "regulation of toluene catabolic process", "definition": "Any process that modulates the frequency, rate or extent of toluene catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547304", "aliases": ["up regulation of response to cycloalkane", "upregulation of response to cycloalkane", "up-regulation of response to cycloalkane"], "types": ["T044"], "canonical_name": "positive regulation of response to cycloalkane", "definition": "Any process that activates or increases the frequency, rate or extent of response to cycloalkane. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547305", "aliases": ["downregulation of response to cycloalkane", "down regulation of response to cycloalkane", "down-regulation of response to cycloalkane"], "types": ["T038"], "canonical_name": "negative regulation of response to cycloalkane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to cycloalkane. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547306", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to cycloalkane", "definition": "Any process that modulates the frequency, rate or extent of response to cycloalkane. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547307", "aliases": ["downregulation of syringal lignin anabolism", "negative regulation of syringal lignin anabolism", "negative regulation of syringal lignin synthesis", "down-regulation of S-lignin biosynthetic process", "inhibition of S-lignin biosynthetic process", "down-regulation of syringal lignin formation", "down-regulation of syringal lignin biosynthesis", "negative regulation of syringal lignin formation", "down regulation of syringal lignin formation", "down regulation of syringal lignin biosynthesis", "down regulation of syringal lignin anabolism", "down regulation of syringal lignin biosynthetic process", "downregulation of syringal lignin biosynthesis", "down-regulation of syringal lignin anabolism", "downregulation of syringal lignin biosynthetic process", "down regulation of S-lignin biosynthetic process", "down-regulation of syringal lignin biosynthetic process", "inhibition of syringal lignin biosynthesis", "downregulation of syringal lignin synthesis", "inhibition of syringal lignin anabolism", "negative regulation of syringal lignin biosynthesis", "down-regulation of syringal lignin synthesis", "inhibition of syringal lignin synthesis", "down regulation of syringal lignin synthesis", "inhibition of syringal lignin formation", "downregulation of syringal lignin formation", "downregulation of S-lignin biosynthetic process", "negative regulation of S-lignin biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of syringal lignin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547308", "aliases": ["regulation of S-lignin biosynthetic process", "regulation of syringal lignin biosynthesis", "regulation of syringal lignin synthesis", "regulation of syringal lignin anabolism", "regulation of syringal lignin formation"], "types": ["T044"], "canonical_name": "regulation of syringal lignin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of syringal lignin biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547309", "aliases": [], "types": ["T043"], "canonical_name": "response to propan-1-ol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a propan-1-ol stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547310", "aliases": [], "types": ["T043"], "canonical_name": "response to furfural", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a furfural stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547311", "aliases": [], "types": ["T043"], "canonical_name": "response to formic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formic acid stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547312", "aliases": [], "types": ["T043"], "canonical_name": "response to toluene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toluene stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547313", "aliases": [], "types": ["T043"], "canonical_name": "response to benzene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzene stimulus. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547314", "aliases": [], "types": ["T043"], "canonical_name": "response to butan-1-ol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butan-1-ol stimulus. [GOC:mengo_curators, GOC:TermGenie, PMID:24014527]"}
{"concept_id": "C3547315", "aliases": ["up-regulation of response to alcohol", "upregulation of response to alcohol", "up regulation of response to alcohol"], "types": ["T044"], "canonical_name": "positive regulation of response to alcohol", "definition": "Any process that activates or increases the frequency, rate or extent of response to alcohol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547316", "aliases": ["down-regulation of response to alcohol", "down regulation of response to alcohol", "downregulation of response to alcohol"], "types": ["T038"], "canonical_name": "negative regulation of response to alcohol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to alcohol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547317", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to alcohol", "definition": "Any process that modulates the frequency, rate or extent of response to alcohol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547318", "aliases": ["upregulation of response to ethanol", "up regulation of response to ethanol", "up-regulation of response to ethanol"], "types": ["T044"], "canonical_name": "positive regulation of response to ethanol", "definition": "Any process that activates or increases the frequency, rate or extent of response to ethanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547319", "aliases": ["down regulation of response to ethanol", "down-regulation of response to ethanol", "downregulation of response to ethanol"], "types": ["T038"], "canonical_name": "negative regulation of response to ethanol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to ethanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547320", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to ethanol", "definition": "Any process that modulates the frequency, rate or extent of response to ethanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547321", "aliases": ["upregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "upregulation of tetrapyrrole synthesis from glycine and succinyl-CoA", "up regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "activation of tetrapyrrole synthesis from glycine and succinyl-CoA", "positive regulation of tetrapyrrole formation from glycine and succinyl-CoA", "up regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "upregulation of tetrapyrrole formation from glycine and succinyl-CoA", "activation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "up-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "up-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "activation of tetrapyrrole anabolism from glycine and succinyl-CoA", "positive regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "up regulation of tetrapyrrole anabolism from glycine and succinyl-CoA", "up regulation of tetrapyrrole synthesis from glycine and succinyl-CoA", "upregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "up-regulation of tetrapyrrole formation from glycine and succinyl-CoA", "positive regulation of tetrapyrrole anabolism from glycine and succinyl-CoA", "up-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA", "upregulation of tetrapyrrole anabolism from glycine and succinyl-CoA", "up-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA", "positive regulation of tetrapyrrole synthesis from glycine and succinyl-CoA", "activation of tetrapyrrole formation from glycine and succinyl-CoA", "up regulation of tetrapyrrole formation from glycine and succinyl-CoA"], "types": ["T040"], "canonical_name": "positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "definition": "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547322", "aliases": ["inhibition of tetrapyrrole formation from glycine and succinyl-CoA", "down-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "downregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "inhibition of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "down regulation of tetrapyrrole synthesis from glycine and succinyl-CoA", "down-regulation of tetrapyrrole formation from glycine and succinyl-CoA", "downregulation of tetrapyrrole formation from glycine and succinyl-CoA", "inhibition of tetrapyrrole anabolism from glycine and succinyl-CoA", "downregulation of tetrapyrrole synthesis from glycine and succinyl-CoA", "down-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "downregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "down-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA", "downregulation of tetrapyrrole anabolism from glycine and succinyl-CoA", "negative regulation of tetrapyrrole synthesis from glycine and succinyl-CoA", "negative regulation of tetrapyrrole formation from glycine and succinyl-CoA", "down regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "negative regulation of tetrapyrrole anabolism from glycine and succinyl-CoA", "down regulation of tetrapyrrole formation from glycine and succinyl-CoA", "down-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA", "inhibition of tetrapyrrole synthesis from glycine and succinyl-CoA", "down regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "negative regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "down regulation of tetrapyrrole anabolism from glycine and succinyl-CoA"], "types": ["T044"], "canonical_name": "negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547323", "aliases": ["regulation of tetrapyrrole anabolism from glycine and succinyl-CoA", "regulation of tetrapyrrole synthesis from glycine and succinyl-CoA", "regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA", "regulation of tetrapyrrole formation from glycine and succinyl-CoA"], "types": ["T044"], "canonical_name": "regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA", "definition": "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547324", "aliases": ["up-regulation of tetrapyrrole biosynthetic process from glutamate", "positive regulation of tetrapyrrole anabolism from glutamate", "upregulation of tetrapyrrole anabolism from glutamate", "activation of tetrapyrrole anabolism from glutamate", "up-regulation of tetrapyrrole biosynthesis from glutamate", "positive regulation of tetrapyrrole biosynthesis from glutamate", "positive regulation of tetrapyrrole formation from glutamate", "activation of tetrapyrrole synthesis from glutamate", "up regulation of tetrapyrrole biosynthetic process from glutamate", "upregulation of tetrapyrrole biosynthetic process from glutamate", "upregulation of tetrapyrrole synthesis from glutamate", "up-regulation of tetrapyrrole formation from glutamate", "activation of tetrapyrrole formation from glutamate", "up-regulation of tetrapyrrole synthesis from glutamate", "upregulation of tetrapyrrole biosynthesis from glutamate", "up regulation of tetrapyrrole anabolism from glutamate", "up regulation of tetrapyrrole synthesis from glutamate", "up regulation of tetrapyrrole formation from glutamate", "up regulation of tetrapyrrole biosynthesis from glutamate", "activation of tetrapyrrole biosynthesis from glutamate", "positive regulation of tetrapyrrole synthesis from glutamate", "upregulation of tetrapyrrole formation from glutamate", "up-regulation of tetrapyrrole anabolism from glutamate"], "types": ["T044"], "canonical_name": "positive regulation of tetrapyrrole biosynthetic process from glutamate", "definition": "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547325", "aliases": ["down-regulation of tetrapyrrole biosynthesis from glutamate", "negative regulation of tetrapyrrole biosynthesis from glutamate", "down regulation of tetrapyrrole biosynthesis from glutamate", "downregulation of tetrapyrrole synthesis from glutamate", "negative regulation of tetrapyrrole anabolism from glutamate", "down regulation of tetrapyrrole formation from glutamate", "inhibition of tetrapyrrole anabolism from glutamate", "down-regulation of tetrapyrrole anabolism from glutamate", "down regulation of tetrapyrrole biosynthetic process from glutamate", "downregulation of tetrapyrrole biosynthetic process from glutamate", "inhibition of tetrapyrrole synthesis from glutamate", "inhibition of tetrapyrrole formation from glutamate", "down regulation of tetrapyrrole anabolism from glutamate", "negative regulation of tetrapyrrole synthesis from glutamate", "inhibition of tetrapyrrole biosynthesis from glutamate", "downregulation of tetrapyrrole formation from glutamate", "down-regulation of tetrapyrrole biosynthetic process from glutamate", "downregulation of tetrapyrrole anabolism from glutamate", "down-regulation of tetrapyrrole synthesis from glutamate", "negative regulation of tetrapyrrole formation from glutamate", "downregulation of tetrapyrrole biosynthesis from glutamate", "down regulation of tetrapyrrole synthesis from glutamate", "down-regulation of tetrapyrrole formation from glutamate"], "types": ["T044"], "canonical_name": "negative regulation of tetrapyrrole biosynthetic process from glutamate", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547326", "aliases": ["regulation of tetrapyrrole biosynthesis from glutamate", "regulation of tetrapyrrole synthesis from glutamate", "regulation of tetrapyrrole formation from glutamate", "regulation of tetrapyrrole anabolism from glutamate"], "types": ["T044"], "canonical_name": "regulation of tetrapyrrole biosynthetic process from glutamate", "definition": "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547327", "aliases": ["upregulation of CTD domain phosphorylation of RNA polymerase II", "up-regulation of generation of hyperphosphorylated CTD of RNA polymerase II", "up regulation of CTD domain phosphorylation of RNA polymerase II", "positive regulation of CTD domain phosphorylation of RNA polymerase II", "activation of hyperphosphorylation of RNA polymerase II C-terminal domain", "up-regulation of CTD domain phosphorylation of RNA polymerase II", "up-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain", "up-regulation of phosphorylation of RNA polymerase II C-terminal domain", "upregulation of generation of hyperphosphorylated CTD of RNA polymerase II", "up regulation of generation of II(0) form of RNA polymerase II", "up regulation of phosphorylation of RNA polymerase II C-terminal domain", "positive regulation of generation of hyperphosphorylated CTD of RNA polymerase II", "upregulation of phosphorylation of RNA polymerase II C-terminal domain", "up regulation of generation of hyperphosphorylated CTD of RNA polymerase II", "activation of generation of II(0) form of RNA polymerase II", "up-regulation of generation of II(0) form of RNA polymerase II", "upregulation of generation of II(0) form of RNA polymerase II", "activation of CTD domain phosphorylation of RNA polymerase II", "upregulation of hyperphosphorylation of RNA polymerase II C-terminal domain", "positive regulation of hyperphosphorylation of RNA polymerase II C-terminal domain", "up regulation of hyperphosphorylation of RNA polymerase II C-terminal domain", "activation of generation of hyperphosphorylated CTD of RNA polymerase II", "positive regulation of generation of II(0) form of RNA polymerase II"], "types": ["T045"], "canonical_name": "positive regulation of phosphorylation of RNA polymerase II C-terminal domain", "definition": "Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain. [GOC:TermGenie]"}
{"concept_id": "C3547328", "aliases": ["down regulation of hyperphosphorylation of RNA polymerase II C-terminal domain", "downregulation of CTD domain phosphorylation of RNA polymerase II", "down regulation of phosphorylation of RNA polymerase II C-terminal domain", "negative regulation of generation of hyperphosphorylated CTD of RNA polymerase II", "negative regulation of CTD domain phosphorylation of RNA polymerase II", "down regulation of generation of hyperphosphorylated CTD of RNA polymerase II", "negative regulation of generation of II(0) form of RNA polymerase II", "down-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain", "downregulation of generation of hyperphosphorylated CTD of RNA polymerase II", "inhibition of CTD domain phosphorylation of RNA polymerase II", "downregulation of generation of II(0) form of RNA polymerase II", "down regulation of generation of II(0) form of RNA polymerase II", "down-regulation of generation of II(0) form of RNA polymerase II", "downregulation of phosphorylation of RNA polymerase II C-terminal domain", "downregulation of hyperphosphorylation of RNA polymerase II C-terminal domain", "negative regulation of hyperphosphorylation of RNA polymerase II C-terminal domain", "inhibition of hyperphosphorylation of RNA polymerase II C-terminal domain", "inhibition of generation of II(0) form of RNA polymerase II", "down-regulation of generation of hyperphosphorylated CTD of RNA polymerase II", "down-regulation of CTD domain phosphorylation of RNA polymerase II", "down regulation of CTD domain phosphorylation of RNA polymerase II", "inhibition of generation of hyperphosphorylated CTD of RNA polymerase II", "down-regulation of phosphorylation of RNA polymerase II C-terminal domain"], "types": ["T045"], "canonical_name": "negative regulation of phosphorylation of RNA polymerase II C-terminal domain", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain. [GOC:TermGenie]"}
{"concept_id": "C3547329", "aliases": ["regulation of CTD domain phosphorylation of RNA polymerase II", "regulation of hyperphosphorylation of RNA polymerase II C-terminal domain", "regulation of generation of hyperphosphorylated CTD of RNA polymerase II", "regulation of generation of II(0) form of RNA polymerase II"], "types": ["T045"], "canonical_name": "regulation of phosphorylation of RNA polymerase II C-terminal domain", "definition": "Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain. [GOC:TermGenie]"}
{"concept_id": "C3547330", "aliases": ["up regulation of tetrapyrrole catabolic process", "activation of tetrapyrrole catabolism", "positive regulation of tetrapyrrole degradation", "up-regulation of tetrapyrrole catabolic process", "upregulation of tetrapyrrole degradation", "activation of tetrapyrrole degradation", "up regulation of tetrapyrrole degradation", "positive regulation of tetrapyrrole breakdown", "activation of tetrapyrrole breakdown", "positive regulation of tetrapyrrole catabolism", "upregulation of tetrapyrrole catabolism", "up-regulation of tetrapyrrole catabolism", "upregulation of tetrapyrrole catabolic process", "up-regulation of tetrapyrrole breakdown", "up regulation of tetrapyrrole breakdown", "upregulation of tetrapyrrole breakdown", "up regulation of tetrapyrrole catabolism", "up-regulation of tetrapyrrole degradation"], "types": ["T044"], "canonical_name": "positive regulation of tetrapyrrole catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547331", "aliases": ["downregulation of tetrapyrrole catabolic process", "down-regulation of tetrapyrrole catabolic process", "inhibition of tetrapyrrole catabolism", "down regulation of tetrapyrrole degradation", "downregulation of tetrapyrrole breakdown", "down regulation of tetrapyrrole catabolic process", "downregulation of tetrapyrrole degradation", "inhibition of tetrapyrrole breakdown", "inhibition of tetrapyrrole degradation", "down regulation of tetrapyrrole breakdown", "down-regulation of tetrapyrrole breakdown", "down-regulation of tetrapyrrole degradation", "negative regulation of tetrapyrrole breakdown", "down-regulation of tetrapyrrole catabolism", "downregulation of tetrapyrrole catabolism", "negative regulation of tetrapyrrole degradation", "negative regulation of tetrapyrrole catabolism", "down regulation of tetrapyrrole catabolism"], "types": ["T044"], "canonical_name": "negative regulation of tetrapyrrole catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547332", "aliases": ["regulation of tetrapyrrole degradation", "regulation of tetrapyrrole breakdown", "regulation of tetrapyrrole catabolism"], "types": ["T044"], "canonical_name": "regulation of tetrapyrrole catabolic process", "definition": "Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547333", "aliases": ["up regulation of tetrapyrrole metabolic process", "upregulation of tetrapyrrole metabolic process", "up regulation of tetrapyrrole metabolism", "up-regulation of tetrapyrrole metabolic process", "upregulation of tetrapyrrole metabolism", "activation of tetrapyrrole metabolism", "up-regulation of tetrapyrrole metabolism", "positive regulation of tetrapyrrole metabolism"], "types": ["T044"], "canonical_name": "positive regulation of tetrapyrrole metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547334", "aliases": ["downregulation of tetrapyrrole metabolism", "inhibition of tetrapyrrole metabolism", "downregulation of tetrapyrrole metabolic process", "down regulation of tetrapyrrole metabolism", "down-regulation of tetrapyrrole metabolic process", "down regulation of tetrapyrrole metabolic process", "down-regulation of tetrapyrrole metabolism", "negative regulation of tetrapyrrole metabolism"], "types": ["T044"], "canonical_name": "negative regulation of tetrapyrrole metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547335", "aliases": ["regulation of tetrapyrrole metabolism"], "types": ["T044"], "canonical_name": "regulation of tetrapyrrole metabolic process", "definition": "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547336", "aliases": ["up regulation of transforming growth factor beta3 activation", "activation of TGFB3 activation", "positive regulation of TGFB3 activation", "up-regulation of TGFB3 activation", "upregulation of TGFbeta 3 activation", "up regulation of TGFbeta 3 activation", "positive regulation of TGFbeta 3 activation", "upregulation of transforming growth factor beta3 activation", "up regulation of TGFB3 activation", "up-regulation of transforming growth factor beta3 activation", "activation of TGF-beta 3 activation", "up regulation of TGF-beta 3 activation", "upregulation of TGFB3 activation", "activation of TGFbeta 3 activation", "up-regulation of TGFbeta 3 activation", "positive regulation of TGF-beta 3 activation", "upregulation of TGF-beta 3 activation", "up-regulation of TGF-beta 3 activation"], "types": ["T044"], "canonical_name": "positive regulation of transforming growth factor beta3 activation", "definition": "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta3 activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547337", "aliases": ["down regulation of transforming growth factor beta3 activation", "downregulation of TGFbeta 3 activation", "inhibition of TGFB3 activation", "downregulation of transforming growth factor beta3 activation", "down-regulation of TGF-beta 3 activation", "inhibition of TGFbeta 3 activation", "down-regulation of TGFB3 activation", "downregulation of TGFB3 activation", "negative regulation of TGFbeta 3 activation", "down-regulation of TGFbeta 3 activation", "negative regulation of TGF-beta 3 activation", "down regulation of TGFbeta 3 activation", "downregulation of TGF-beta 3 activation", "inhibition of TGF-beta 3 activation", "down-regulation of transforming growth factor beta3 activation", "down regulation of TGFB3 activation", "negative regulation of TGFB3 activation", "down regulation of TGF-beta 3 activation"], "types": ["T044"], "canonical_name": "negative regulation of transforming growth factor beta3 activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta3 activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547338", "aliases": ["regulation of TGFbeta 3 activation", "regulation of TGF-beta 3 activation", "regulation of TGFB3 activation"], "types": ["T044"], "canonical_name": "regulation of transforming growth factor beta3 activation", "definition": "Any process that modulates the frequency, rate or extent of transforming growth factor beta3 activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547339", "aliases": ["up-regulation of TGFbeta 2 activation", "up regulation of transforming growth factor beta2 activation", "positive regulation of TGF-beta 2 activation", "up regulation of TGF-beta 2 activation", "up regulation of TGFB2 activation", "upregulation of TGF-beta 2 activation", "up-regulation of transforming growth factor beta2 activation", "up regulation of TGFbeta 2 activation", "activation of TGF-beta 2 activation", "positive regulation of TGFbeta 2 activation", "upregulation of transforming growth factor beta2 activation", "up-regulation of TGFB2 activation", "up-regulation of TGF-beta 2 activation", "positive regulation of TGFB2 activation", "upregulation of TGFbeta 2 activation", "activation of TGFB2 activation", "activation of TGFbeta 2 activation", "upregulation of TGFB2 activation"], "types": ["T044"], "canonical_name": "positive regulation of transforming growth factor beta2 activation", "definition": "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta2 activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547340", "aliases": ["downregulation of TGF-beta 2 activation", "down regulation of TGF-beta 2 activation", "negative regulation of TGFB2 activation", "down regulation of TGFB2 activation", "down-regulation of TGF-beta 2 activation", "inhibition of TGFbeta 2 activation", "down-regulation of transforming growth factor beta2 activation", "inhibition of TGF-beta 2 activation", "downregulation of transforming growth factor beta2 activation", "down regulation of TGFbeta 2 activation", "down-regulation of TGFbeta 2 activation", "down regulation of transforming growth factor beta2 activation", "down-regulation of TGFB2 activation", "downregulation of TGFbeta 2 activation", "negative regulation of TGFbeta 2 activation", "negative regulation of TGF-beta 2 activation", "downregulation of TGFB2 activation", "inhibition of TGFB2 activation"], "types": ["T044"], "canonical_name": "negative regulation of transforming growth factor beta2 activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta2 activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547341", "aliases": ["regulation of TGFbeta 2 activation", "regulation of TGFB2 activation", "regulation of TGF-beta 2 activation"], "types": ["T044"], "canonical_name": "regulation of transforming growth factor beta2 activation", "definition": "Any process that modulates the frequency, rate or extent of transforming growth factor beta2 activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547342", "aliases": ["positive regulation of transforming growth factor-beta1 activation", "up-regulation of latent-TGF-beta1 activation", "up-regulation of transforming growth factor beta1 activation", "upregulation of transforming growth factor-beta1 activation", "activation of TGF-beta 1 activation", "positive regulation of latent-TGF-beta1 activation", "up-regulation of TGFbeta 1 activation", "up regulation of TGF-beta 1 activation", "positive regulation of TGFbeta 1 activation", "up regulation of latent-TGF-beta1 activation", "activation of TGFbeta 1 activation", "upregulation of L-TGF-beta 1 activation", "activation of TGFB1 activation", "up regulation of TGFbeta 1 activation", "upregulation of latent-TGF-beta1 activation", "activation of L-TGF-beta 1 activation", "up regulation of TGFB1 activation", "up-regulation of TGF-beta 1 activation", "upregulation of transforming growth factor beta1 activation", "up regulation of transforming growth factor-beta1 activation", "activation of transforming growth factor beta1 activation", "upregulation of TGFB1 activation", "up-regulation of L-TGF-beta 1 activation", "up-regulation of transforming growth factor-beta1 activation", "upregulation of TGFbeta 1 activation", "positive regulation of L-TGF-beta 1 activation", "up regulation of transforming growth factor beta1 activation", "activation of transforming growth factor-beta1 activation", "positive regulation of TGF-beta 1 activation", "activation of latent-TGF-beta1 activation", "up regulation of L-TGF-beta 1 activation", "positive regulation of TGFB1 activation", "up-regulation of TGFB1 activation", "upregulation of TGF-beta 1 activation"], "types": ["T044"], "canonical_name": "positive regulation of transforming growth factor beta1 activation", "definition": "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta1 activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547343", "aliases": ["negative regulation of transforming growth factor-beta1 activation", "down-regulation of latent-TGF-beta1 activation", "down regulation of transforming growth factor beta1 activation", "downregulation of L-TGF-beta 1 activation", "downregulation of TGF-beta 1 activation", "downregulation of TGFbeta 1 activation", "negative regulation of latent-TGF-beta1 activation", "downregulation of transforming growth factor beta1 activation", "down regulation of TGFbeta 1 activation", "inhibition of latent-TGF-beta1 activation", "downregulation of latent-TGF-beta1 activation", "down regulation of transforming growth factor-beta1 activation", "down regulation of TGFB1 activation", "down regulation of TGF-beta 1 activation", "inhibition of TGF-beta 1 activation", "negative regulation of TGF-beta 1 activation", "down-regulation of TGF-beta 1 activation", "downregulation of transforming growth factor-beta1 activation", "negative regulation of TGFbeta 1 activation", "inhibition of transforming growth factor-beta1 activation", "down regulation of latent-TGF-beta1 activation", "down regulation of L-TGF-beta 1 activation", "inhibition of transforming growth factor beta1 activation", "down-regulation of transforming growth factor-beta1 activation", "inhibition of TGFbeta 1 activation", "negative regulation of TGFB1 activation", "inhibition of L-TGF-beta 1 activation", "downregulation of TGFB1 activation", "down-regulation of TGFB1 activation", "negative regulation of L-TGF-beta 1 activation", "down-regulation of TGFbeta 1 activation", "down-regulation of transforming growth factor beta1 activation", "down-regulation of L-TGF-beta 1 activation", "inhibition of TGFB1 activation"], "types": ["T044"], "canonical_name": "negative regulation of transforming growth factor beta1 activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta1 activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547344", "aliases": ["regulation of L-TGF-beta 1 activation", "regulation of TGFB1 activation", "regulation of TGF-beta 1 activation", "regulation of latent-TGF-beta1 activation", "regulation of transforming growth factor-beta1 activation", "regulation of TGFbeta 1 activation"], "types": ["T044"], "canonical_name": "regulation of transforming growth factor beta1 activation", "definition": "Any process that modulates the frequency, rate or extent of transforming growth factor beta1 activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547345", "aliases": ["positive regulation of TGF-beta activation", "up regulation of TGF-B activation", "up-regulation of TGF-B activation", "up regulation of latent TGF-beta activation", "activation of TGFbeta activation", "up-regulation of TGF-beta activation", "upregulation of latent TGF-beta activation", "activation of latent TGF-beta activation", "up-regulation of TGFbeta activation", "upregulation of L-TGF-beta activation", "up-regulation of latent TGF-beta activation", "positive regulation of TGF-B activation", "up regulation of TGFB activation", "activation of TGFB activation", "positive regulation of latent TGF-beta activation", "activation of TGF-beta activation", "up-regulation of L-TGF-beta activation", "activation of TGF-B activation", "upregulation of transforming growth factor beta activation", "upregulation of TGF-B activation", "up regulation of L-TGF-beta activation", "up regulation of transforming growth factor beta activation", "up regulation of TGF-beta activation", "upregulation of TGFB activation", "up regulation of TGFbeta activation", "positive regulation of L-TGF-beta activation", "up-regulation of TGFB activation", "positive regulation of TGFB activation", "upregulation of TGF-beta activation", "positive regulation of TGFbeta activation", "upregulation of TGFbeta activation", "activation of L-TGF-beta activation", "up-regulation of transforming growth factor beta activation"], "types": ["T044"], "canonical_name": "positive regulation of transforming growth factor beta activation", "definition": "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547346", "aliases": ["down-regulation of TGF-B activation", "negative regulation of TGFB activation", "negative regulation of TGFbeta activation", "inhibition of TGF-beta activation", "negative regulation of latent TGF-beta activation", "down-regulation of L-TGF-beta activation", "down-regulation of transforming growth factor beta activation", "negative regulation of L-TGF-beta activation", "inhibition of latent TGF-beta activation", "down-regulation of latent TGF-beta activation", "down regulation of transforming growth factor beta activation", "downregulation of latent TGF-beta activation", "downregulation of TGF-B activation", "downregulation of L-TGF-beta activation", "inhibition of TGFB activation", "down-regulation of TGF-beta activation", "down regulation of TGF-B activation", "inhibition of TGF-B activation", "negative regulation of TGF-beta activation", "down-regulation of TGFB activation", "down-regulation of TGFbeta activation", "inhibition of L-TGF-beta activation", "inhibition of TGFbeta activation", "down regulation of L-TGF-beta activation", "down regulation of TGFB activation", "down regulation of TGF-beta activation", "downregulation of TGF-beta activation", "negative regulation of TGF-B activation", "down regulation of latent TGF-beta activation", "downregulation of TGFbeta activation", "downregulation of transforming growth factor beta activation", "down regulation of TGFbeta activation", "downregulation of TGFB activation"], "types": ["T044"], "canonical_name": "negative regulation of transforming growth factor beta activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547347", "aliases": ["regulation of L-TGF-beta activation", "regulation of TGF-beta activation", "regulation of TGF-B activation", "regulation of latent TGF-beta activation", "regulation of TGFbeta activation", "regulation of TGFB activation"], "types": ["T044"], "canonical_name": "regulation of transforming growth factor beta activation", "definition": "Any process that modulates the frequency, rate or extent of transforming growth factor beta activation. [GOC:sl, GOC:TermGenie]"}
{"concept_id": "C3547348", "aliases": ["up regulation of depolarization-activated voltage-gated calcium channel activity", "upregulation of depolarization-activated voltage gated calcium channel activity", "up-regulation of voltage-gated calcium channel activity", "up regulation of voltage-dependent calcium channel activity", "up-regulation of depolarization-activated voltage gated calcium channel activity", "upregulation of voltage-gated calcium channel activity", "up regulation of voltage-sensitive calcium channel", "upregulation of voltage-sensitive calcium channel", "activation of voltage gated calcium channel activity", "activation of voltage-sensitive calcium channel", "up-regulation of depolarization-activated voltage-gated calcium channel", "upregulation of depolarization-activated voltage-gated calcium channel", "up regulation of voltage-gated calcium ion channel activity", "up-regulation of voltage-gated calcium ion channel activity", "activation of voltage-gated calcium channel activity", "positive regulation of voltage-gated calcium ion channel activity", "positive regulation of depolarization-activated voltage-gated calcium channel activity", "up-regulation of depolarization-activated voltage-gated calcium channel activity", "up-regulation of voltage-sensitive calcium channel", "up regulation of depolarization-activated voltage-gated calcium channel", "positive regulation of depolarization-activated voltage gated calcium channel activity", "up-regulation of voltage-dependent calcium channel activity", "positive regulation of depolarization-activated voltage-gated calcium channel", "upregulation of voltage gated calcium channel activity", "activation of voltage-dependent calcium channel activity", "activation of depolarization-activated voltage-gated calcium channel activity", "up regulation of voltage gated calcium channel activity", "up regulation of depolarization-activated voltage gated calcium channel activity", "activation of depolarization-activated voltage gated calcium channel activity", "activation of depolarization-activated voltage-gated calcium channel", "positive regulation of voltage-sensitive calcium channel", "upregulation of voltage-dependent calcium channel activity", "upregulation of depolarization-activated voltage-gated calcium channel activity", "positive regulation of voltage-dependent calcium channel activity", "positive regulation of voltage gated calcium channel activity", "upregulation of voltage-gated calcium ion channel activity", "up-regulation of voltage gated calcium channel activity", "activation of voltage-gated calcium ion channel activity", "up regulation of voltage-gated calcium channel activity"], "types": ["T044"], "canonical_name": "positive regulation of voltage-gated calcium channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547349", "aliases": ["inhibition of voltage-gated calcium ion channel activity", "negative regulation of depolarization-activated voltage-gated calcium channel activity", "down regulation of voltage-dependent calcium channel activity", "downregulation of depolarization-activated voltage gated calcium channel activity", "down-regulation of voltage-gated calcium channel activity", "downregulation of depolarization-activated voltage-gated calcium channel activity", "negative regulation of voltage-gated calcium ion channel activity", "down regulation of voltage-gated calcium channel activity", "down regulation of depolarization-activated voltage-gated calcium channel", "down regulation of voltage gated calcium channel activity", "inhibition of depolarization-activated voltage-gated calcium channel activity", "inhibition of voltage-dependent calcium channel activity", "down-regulation of depolarization-activated voltage gated calcium channel activity", "down-regulation of voltage-sensitive calcium channel", "down regulation of depolarization-activated voltage-gated calcium channel activity", "negative regulation of voltage-dependent calcium channel activity", "negative regulation of depolarization-activated voltage-gated calcium channel", "negative regulation of voltage-sensitive calcium channel", "inhibition of voltage-gated calcium channel activity", "negative regulation of voltage gated calcium channel activity", "downregulation of depolarization-activated voltage-gated calcium channel", "down-regulation of depolarization-activated voltage-gated calcium channel activity", "down regulation of voltage-sensitive calcium channel", "downregulation of voltage gated calcium channel activity", "down-regulation of voltage-gated calcium ion channel activity", "downregulation of voltage-gated calcium channel activity", "down-regulation of voltage gated calcium channel activity", "inhibition of depolarization-activated voltage gated calcium channel activity", "inhibition of depolarization-activated voltage-gated calcium channel", "down-regulation of depolarization-activated voltage-gated calcium channel", "inhibition of voltage gated calcium channel activity", "down regulation of depolarization-activated voltage gated calcium channel activity", "down-regulation of voltage-dependent calcium channel activity", "downregulation of voltage-dependent calcium channel activity", "downregulation of voltage-sensitive calcium channel", "negative regulation of depolarization-activated voltage gated calcium channel activity", "inhibition of voltage-sensitive calcium channel", "downregulation of voltage-gated calcium ion channel activity", "down regulation of voltage-gated calcium ion channel activity"], "types": ["T044"], "canonical_name": "negative regulation of voltage-gated calcium channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547350", "aliases": ["regulation of voltage gated calcium channel activity", "regulation of depolarization-activated voltage-gated calcium channel", "regulation of depolarization-activated voltage gated calcium channel activity", "regulation of depolarization-activated voltage-gated calcium channel activity", "regulation of voltage-sensitive calcium channel", "regulation of voltage-dependent calcium channel activity", "regulation of voltage-gated calcium ion channel activity"], "types": ["T044"], "canonical_name": "regulation of voltage-gated calcium channel activity", "definition": "Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547351", "aliases": ["up-regulation of chorionic trophoblast cell proliferation", "up regulation of chorionic trophoblast cell proliferation", "upregulation of chorionic trophoblast cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of chorionic trophoblast cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547352", "aliases": ["down regulation of chorionic trophoblast cell proliferation", "downregulation of chorionic trophoblast cell proliferation", "down-regulation of chorionic trophoblast cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of chorionic trophoblast cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547353", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chorionic trophoblast cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547354", "aliases": ["up-regulation of potassium ion transmembrane transport", "up regulation of potassium ion transmembrane transport", "positive regulation of potassium ion membrane transport", "upregulation of potassium ion transmembrane transport"], "types": ["T043"], "canonical_name": "positive regulation of potassium ion transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547355", "aliases": ["down regulation of potassium ion transmembrane transport", "negative regulation of potassium ion membrane transport", "downregulation of potassium ion transmembrane transport", "down-regulation of potassium ion transmembrane transport"], "types": ["T043"], "canonical_name": "negative regulation of potassium ion transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547356", "aliases": ["regulation of potassium ion membrane transport"], "types": ["T043"], "canonical_name": "regulation of potassium ion transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547357", "aliases": ["organic heteropentacyclic compound synthesis", "organic heteropentacyclic compound anabolism", "organic heteropentacyclic compound biosynthesis", "organic heteropentacyclic compound formation"], "types": ["T044"], "canonical_name": "organic heteropentacyclic compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of organic heteropentacyclic compound. [GOC:TermGenie]"}
{"concept_id": "C3547358", "aliases": ["organic heteropentacyclic compound degradation", "organic heteropentacyclic compound breakdown", "organic heteropentacyclic compound catabolism"], "types": ["T044"], "canonical_name": "organic heteropentacyclic compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of organic heteropentacyclic compound. [GOC:TermGenie]"}
{"concept_id": "C3547359", "aliases": ["organic heteropentacyclic compound metabolism"], "types": ["T044"], "canonical_name": "organic heteropentacyclic compound metabolic process", "definition": "The chemical reactions and pathways involving organic heteropentacyclic compound. [GOC:TermGenie]"}
{"concept_id": "C3547360", "aliases": [], "types": ["T044"], "canonical_name": "acetate ester transmembrane transporter activity", "definition": "Enables the transfer of an acetate ester from one side of a membrane to the other. [GOC:TermGenie]"}
{"concept_id": "C3547361", "aliases": [], "types": ["T043"], "canonical_name": "acetate ester transport", "definition": "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie]"}
{"concept_id": "C3547362", "aliases": [], "types": ["T043"], "canonical_name": "lipid hydroperoxide transport", "definition": "The directed movement of a lipid hydroperoxide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie]"}
{"concept_id": "C3547364", "aliases": [], "types": ["T039"], "canonical_name": "regulation of leaf morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of leaf morphogenesis. [GOC:TermGenie]"}
{"concept_id": "C3547365", "aliases": [], "types": ["T040"], "canonical_name": "response to glutathione", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547366", "aliases": ["cyclic 2,3-bisphospho-D-glyceric acid anabolism", "cyclic 2,3-bisphospho-D-glyceric acid biosynthetic process", "cyclic 2,3-bisphospho-D-glyceric acid biosynthesis", "cyclic 2,3-bisphospho-D-glyceric acid formation", "cyclic 2,3-diphosphoglycerate biosynthesis", "cDPG biosynthesis", "cyclic 2,3-bisphospho-D-glyceric acid synthesis"], "types": ["T044"], "canonical_name": "cyclic 2,3-bisphospho-D-glycerate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cyclic 2,3-bisphospho-D-glyceric acid. [GOC:bf, GOC:crds, GOC:TermGenie, PMID:2226838]"}
{"concept_id": "C3547367", "aliases": [], "types": ["T040"], "canonical_name": "response to L-cysteine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547368", "aliases": ["funalenone synthesis", "funalenone formation", "funalenone biosynthesis", "funalenone anabolism"], "types": ["T044"], "canonical_name": "funalenone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of funalenone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547369", "aliases": ["funalenone breakdown", "funalenone degradation", "funalenone catabolism"], "types": ["T044"], "canonical_name": "funalenone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of funalenone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547370", "aliases": ["funalenone metabolism"], "types": ["T044"], "canonical_name": "funalenone metabolic process", "definition": "The chemical reactions and pathways involving funalenone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547371", "aliases": [], "types": ["T044"], "canonical_name": "heterocyclic compound binding", "definition": "Binding to heterocyclic compound. [GOC:TermGenie]"}
{"concept_id": "C3547372", "aliases": ["organic cyclic compound formation", "organic cyclic compound anabolism", "organic cyclic compound biosynthesis", "organic cyclic compound synthesis"], "types": ["T044"], "canonical_name": "organic cyclic compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of organic cyclic compound. [GOC:TermGenie]"}
{"concept_id": "C3547373", "aliases": ["organic cyclic compound degradation", "organic cyclic compound breakdown", "organic cyclic compound catabolism"], "types": ["T044"], "canonical_name": "organic cyclic compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. [GOC:TermGenie]"}
{"concept_id": "C3547374", "aliases": ["organic cyclic compound metabolism"], "types": ["T044"], "canonical_name": "organic cyclic compound metabolic process", "definition": "The chemical reactions and pathways involving organic cyclic compound. [GOC:TermGenie]"}
{"concept_id": "C3547375", "aliases": [], "types": ["T044"], "canonical_name": "tungstate binding", "definition": "Binding to tungstate. [GOC:TermGenie]"}
{"concept_id": "C3547376", "aliases": ["beta-D-galactofuranose anabolism", "beta-D-galactofuranose formation", "beta-D-galactofuranose synthesis", "beta-D-galactofuranose biosynthesis"], "types": ["T044"], "canonical_name": "beta-D-galactofuranose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of beta-D-galactofuranose. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547377", "aliases": ["beta-D-galactofuranose degradation", "beta-D-galactofuranose breakdown", "beta-D-galactofuranose catabolism"], "types": ["T044"], "canonical_name": "beta-D-galactofuranose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of beta-D-galactofuranose. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547378", "aliases": ["beta-D-galactofuranose metabolism"], "types": ["T044"], "canonical_name": "beta-D-galactofuranose metabolic process", "definition": "The chemical reactions and pathways involving beta-D-galactofuranose. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547379", "aliases": [], "types": ["T043"], "canonical_name": "response to rapamycin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547380", "aliases": [], "types": ["T040"], "canonical_name": "response to L-canavanine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547381", "aliases": ["up-regulation of phosphatidylglycerol biosynthetic process", "up regulation of phosphatidylglycerol biosynthetic process", "upregulation of phosphatidylglycerol biosynthetic process", "upregulation of phosphatidylglycerol biosynthesis", "upregulation of phosphatidylglycerol anabolism", "up regulation of phosphatidylglycerol anabolism", "positive regulation of phosphatidylglycerol formation", "positive regulation of phosphatidylglycerol synthesis", "up-regulation of phosphatidylglycerol biosynthesis", "up regulation of phosphatidylglycerol formation", "up regulation of phosphatidylglycerol synthesis", "up regulation of phosphatidylglycerol biosynthesis", "positive regulation of phosphatidylglycerol biosynthesis", "up-regulation of phosphatidylglycerol anabolism", "up-regulation of phosphatidylglycerol synthesis", "upregulation of phosphatidylglycerol formation", "positive regulation of phosphatidylglycerol anabolism", "upregulation of phosphatidylglycerol synthesis", "up-regulation of phosphatidylglycerol formation"], "types": ["T044"], "canonical_name": "positive regulation of phosphatidylglycerol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylglycerol biosynthetic process. [GOC:dgf, GOC:TermGenie, PMID:12869188]"}
{"concept_id": "C3547382", "aliases": ["downregulation of phosphatidylglycerol anabolism", "down regulation of phosphatidylglycerol anabolism", "downregulation of phosphatidylglycerol biosynthetic process", "down regulation of phosphatidylglycerol formation", "down-regulation of phosphatidylglycerol biosynthetic process", "down regulation of phosphatidylglycerol synthesis", "negative regulation of phosphatidylglycerol biosynthesis", "downregulation of phosphatidylglycerol synthesis", "negative regulation of phosphatidylglycerol synthesis", "down-regulation of phosphatidylglycerol synthesis", "down regulation of phosphatidylglycerol biosynthetic process", "negative regulation of phosphatidylglycerol formation", "down-regulation of phosphatidylglycerol anabolism", "down regulation of phosphatidylglycerol biosynthesis", "downregulation of phosphatidylglycerol biosynthesis", "downregulation of phosphatidylglycerol formation", "negative regulation of phosphatidylglycerol anabolism", "down-regulation of phosphatidylglycerol biosynthesis", "down-regulation of phosphatidylglycerol formation"], "types": ["T044"], "canonical_name": "negative regulation of phosphatidylglycerol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylglycerol biosynthetic process. [GOC:dgf, GOC:TermGenie, PMID:12869188]"}
{"concept_id": "C3547383", "aliases": ["regulation of phosphatidylglycerol synthesis", "regulation of phosphatidylglycerol biosynthesis", "regulation of phosphatidylglycerol formation", "regulation of phosphatidylglycerol anabolism"], "types": ["T044"], "canonical_name": "regulation of phosphatidylglycerol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylglycerol biosynthetic process. [GOC:dgf, GOC:TermGenie, PMID:12869188]"}
{"concept_id": "C3547385", "aliases": [], "types": ["T043"], "canonical_name": "glucosinolate transport", "definition": "The directed movement of a glucosinolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie]"}
{"concept_id": "C3547386", "aliases": ["up-regulation of plant-type secondary cell wall biogenesis", "positive regulation of plant-type secondary cell wall biogenesis", "up regulation of cellulose and pectin-containing secondary cell wall biogenesis", "up regulation of plant-type secondary cell wall biogenesis", "up regulation of secondary cell wall biogenesis", "upregulation of cellulose and pectin-containing secondary cell wall biogenesis", "upregulation of plant-type secondary cell wall biogenesis", "activation of plant-type secondary cell wall biogenesis", "positive regulation of cellulose and pectin-containing secondary cell wall biogenesis", "up-regulation of cellulose and pectin-containing secondary cell wall biogenesis", "activation of cellulose and pectin-containing secondary cell wall biogenesis", "upregulation of secondary cell wall biogenesis", "up-regulation of secondary cell wall biogenesis"], "types": ["T043"], "canonical_name": "positive regulation of secondary cell wall biogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of secondary cell wall biogenesis. [GOC:TermGenie]"}
{"concept_id": "C3547387", "aliases": ["negative regulation of vasculature development involved in avascular cornea development", "down-regulation of vasculature development involved in avascular cornea development", "downregulation of vasculature development involved in avascular cornea development", "down regulation of vasculature development involved in avascular cornea development in camera-type eye", "down-regulation of vasculature development involved in avascular cornea development in camera-type eye", "down regulation of vasculature development involved in avascular cornea development", "downregulation of vasculature development involved in avascular cornea development in camera-type eye"], "types": ["T042"], "canonical_name": "negative regulation of vasculature development involved in avascular cornea development in camera-type eye", "definition": "Any negative regulation of vasculature development that is involved in developing an avascular cornea of a camera-type eye. [GOC:TermGenie, GOC:uh, PMID:16849433, PMID:17051153]"}
{"concept_id": "C3547388", "aliases": [], "types": ["T040"], "canonical_name": "response to L-thialysine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547389", "aliases": [], "types": ["T043"], "canonical_name": "response to leptomycin B", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547390", "aliases": ["down regulation of vasculature development", "downregulation of vasculature development", "down-regulation of vasculature development"], "types": ["T039"], "canonical_name": "negative regulation of vasculature development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. [GOC:TermGenie]"}
{"concept_id": "C3547391", "aliases": [], "types": ["T039"], "canonical_name": "regulation of vasculature development", "definition": "Any process that modulates the frequency, rate or extent of vasculature development. [GOC:TermGenie]"}
{"concept_id": "C3547392", "aliases": [], "types": ["T044"], "canonical_name": "catecholamine binding", "definition": "Binding to catecholamine. [GOC:TermGenie]"}
{"concept_id": "C3547393", "aliases": [], "types": ["T043"], "canonical_name": "thioester transport", "definition": "The directed movement of a thioester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie]"}
{"concept_id": "C3547394", "aliases": ["lactone synthesis", "lactone biosynthesis", "lactone formation", "lactone anabolism"], "types": ["T044"], "canonical_name": "lactone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lactone. [GOC:TermGenie]"}
{"concept_id": "C3547395", "aliases": ["lactone degradation", "lactone catabolism", "lactone breakdown"], "types": ["T044"], "canonical_name": "lactone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lactone. [GOC:TermGenie]"}
{"concept_id": "C3547396", "aliases": ["lactone metabolism"], "types": ["T044"], "canonical_name": "lactone metabolic process", "definition": "The chemical reactions and pathways involving lactone. [GOC:TermGenie]"}
{"concept_id": "C3547397", "aliases": ["up regulation of lateral root development", "up-regulation of lateral root development", "upregulation of lateral root development"], "types": ["T039"], "canonical_name": "positive regulation of lateral root development", "definition": "Any process that activates or increases the frequency, rate or extent of lateral root development. [GOC:TermGenie]"}
{"concept_id": "C3547398", "aliases": ["down regulation of lateral root development", "downregulation of lateral root development", "down-regulation of lateral root development"], "types": ["T039"], "canonical_name": "negative regulation of lateral root development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lateral root development. [GOC:TermGenie]"}
{"concept_id": "C3547399", "aliases": ["up regulation of odontoblast differentiation", "up-regulation of odontoblast differentiation", "upregulation of odontoblast differentiation"], "types": ["T043"], "canonical_name": "positive regulation of odontoblast differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of odontoblast differentiation. [GOC:TermGenie]"}
{"concept_id": "C3547400", "aliases": ["down-regulation of odontoblast differentiation", "down regulation of odontoblast differentiation", "downregulation of odontoblast differentiation"], "types": ["T043"], "canonical_name": "negative regulation of odontoblast differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of odontoblast differentiation. [GOC:TermGenie]"}
{"concept_id": "C3547401", "aliases": [], "types": ["T043"], "canonical_name": "regulation of odontoblast differentiation", "definition": "Any process that modulates the frequency, rate or extent of odontoblast differentiation. [GOC:TermGenie]"}
{"concept_id": "C3547402", "aliases": [], "types": ["T043"], "canonical_name": "response to cytochalasin B", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547403", "aliases": ["response to FK506", "response to tacrolimus hydrate"], "types": ["T043"], "canonical_name": "response to tacrolimus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547404", "aliases": [], "types": ["T043"], "canonical_name": "response to tetracycline", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547405", "aliases": [], "types": ["T043"], "canonical_name": "response to antimycin A", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547406", "aliases": [], "types": ["T043"], "canonical_name": "response to trichodermin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547407", "aliases": [], "types": ["T043"], "canonical_name": "response to erythromycin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547408", "aliases": [], "types": ["T043"], "canonical_name": "response to chloramphenicol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus. [GOC:TermGenie]"}
{"concept_id": "C3547409", "aliases": ["up-regulation of heart induction", "up regulation of heart induction", "upregulation of heart induction"], "types": ["T043"], "canonical_name": "positive regulation of heart induction", "definition": "Any process that activates or increases the frequency, rate or extent of heart induction. [GOC:TermGenie]"}
{"concept_id": "C3547410", "aliases": ["downregulation of heart induction", "down-regulation of heart induction", "down regulation of heart induction"], "types": ["T043"], "canonical_name": "negative regulation of heart induction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of heart induction. [GOC:TermGenie]"}
{"concept_id": "C3547411", "aliases": ["activation of trehalose degradation", "up-regulation of trehalose catabolic process", "positive regulation of mykose catabolism", "upregulation of trehalose catabolic process", "up regulation of trehalose catabolic process", "upregulation of mykose catabolic process", "up-regulation of mycose catabolic process", "up regulation of mykose catabolic process", "positive regulation of trehalose degradation", "up-regulation of mykose catabolism", "activation of mykose catabolic process", "up regulation of trehalose breakdown", "up regulation of trehalose degradation", "positive regulation of mycose catabolic process", "upregulation of trehalose degradation", "up-regulation of trehalose breakdown", "upregulation of trehalose catabolism", "up-regulation of mycose catabolism", "activation of trehalose catabolism", "upregulation of mycose catabolic process", "activation of mycose catabolic process", "up regulation of mycose catabolism", "upregulation of mykose catabolism", "upregulation of mycose catabolism", "up-regulation of mykose catabolic process", "activation of mycose catabolism", "positive regulation of trehalose catabolism", "up-regulation of trehalose catabolism", "up-regulation of trehalose degradation", "positive regulation of trehalose breakdown", "activation of trehalose breakdown", "up regulation of mycose catabolic process", "up regulation of mykose catabolism", "activation of mykose catabolism", "upregulation of trehalose breakdown", "positive regulation of mykose catabolic process", "up regulation of trehalose catabolism", "positive regulation of mycose catabolism"], "types": ["T044"], "canonical_name": "positive regulation of trehalose catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of trehalose catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3547412", "aliases": ["down-regulation of sperm movement", "downregulation of sperm motility", "down regulation of sperm movement", "down regulation of sperm motility", "negative regulation of sperm movement", "downregulation of sperm movement", "inhibition of sperm movement", "down-regulation of sperm motility"], "types": ["T043"], "canonical_name": "negative regulation of sperm motility"}
{"concept_id": "C3547413", "aliases": ["regulation of sperm movement"], "types": ["T043"], "canonical_name": "regulation of sperm motility"}
{"concept_id": "C3547414", "aliases": ["up-regulation of histone H2A K63-linked ubiquitination", "upregulation of histone H2A K63-linked ubiquitination", "up regulation of histone H2A K63-linked ubiquitination"], "types": ["T044"], "canonical_name": "positive regulation of histone H2A K63-linked ubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of histone H2A K63-linked ubiquitination. [GOC:TermGenie]"}
{"concept_id": "C3547415", "aliases": ["down regulation of histone H2A K63-linked ubiquitination", "down-regulation of histone H2A K63-linked ubiquitination", "downregulation of histone H2A K63-linked ubiquitination"], "types": ["T044"], "canonical_name": "negative regulation of histone H2A K63-linked ubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination. [GOC:TermGenie]"}
{"concept_id": "C3547416", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H2A K63-linked ubiquitination", "definition": "Any process that modulates the frequency, rate or extent of histone H2A K63-linked ubiquitination. [GOC:TermGenie]"}
{"concept_id": "C3547420", "aliases": ["up-regulation of SREBP cleavage", "upregulation of sterol regulatory element binding protein cleavage", "up regulation of sterol regulatory element binding protein cleavage", "up regulation of SREBP cleavage", "up-regulation of sterol regulatory element binding protein cleavage", "activation of SREBP cleavage", "upregulation of SREBP cleavage", "positive regulation of SREBP cleavage"], "types": ["T044"], "canonical_name": "positive regulation of sterol regulatory element binding protein cleavage", "definition": "Any process that activates or increases the frequency, rate or extent of sterol regulatory element binding protein cleavage. [GOC:TermGenie, PMID:15899885, PMID:16525117]"}
{"concept_id": "C3547421", "aliases": ["downregulation of SREBP cleavage", "downregulation of sterol regulatory element binding protein cleavage", "down-regulation of sterol regulatory element binding protein cleavage", "inhibition of SREBP cleavage", "down-regulation of SREBP cleavage", "negative regulation of SREBP cleavage", "down regulation of SREBP cleavage", "down regulation of sterol regulatory element binding protein cleavage", "inhibition of SREBP processing"], "types": ["T045"], "canonical_name": "negative regulation of sterol regulatory element binding protein cleavage", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sterol regulatory element binding protein cleavage. [GOC:TermGenie, PMID:15899885, PMID:16525117]"}
{"concept_id": "C3547422", "aliases": ["regulation of SREBP cleavage"], "types": ["T044"], "canonical_name": "regulation of sterol regulatory element binding protein cleavage", "definition": "Any process that modulates the frequency, rate or extent of sterol regulatory element binding protein cleavage. [GOC:TermGenie]"}
{"concept_id": "C3547423", "aliases": ["downregulation of spermidine biosynthetic process", "downregulation of spermidine anabolism", "inhibition of spermidine biosynthesis", "negative regulation of spermidine biosynthesis", "down-regulation of spermidine biosynthetic process", "inhibition of spermidine anabolism", "down regulation of spermidine anabolism", "negative regulation of spermidine formation", "inhibition of spermidine formation", "down regulation of spermidine biosynthetic process", "negative regulation of spermidine anabolism", "down-regulation of spermidine anabolism", "down-regulation of spermidine formation", "down regulation of spermidine formation", "down-regulation of spermidine biosynthesis", "inhibition of spermidine synthesis", "down regulation of spermidine biosynthesis", "negative regulation of spermidine synthesis", "downregulation of spermidine biosynthesis", "down regulation of spermidine synthesis", "downregulation of spermidine synthesis", "downregulation of spermidine formation", "down-regulation of spermidine synthesis"], "types": ["T040"], "canonical_name": "negative regulation of spermidine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of spermidine biosynthetic process. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3547424", "aliases": ["regulation of spermidine anabolism", "regulation of spermidine formation", "regulation of spermidine synthesis", "regulation of spermidine biosynthesis"], "types": ["T044"], "canonical_name": "regulation of spermidine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of spermidine biosynthetic process. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3547425", "aliases": ["downregulation of cargo loading into COPII vesicle", "downregulation of cargo selection into COPII-coated vesicle", "down-regulation of cargo selection into COPII-coated vesicle", "down regulation of cargo selection into COPII-coated vesicle", "down regulation of cargo loading into COPII vesicle", "down-regulation of cargo loading into COPII vesicle", "inhibition of cargo loading into COPII vesicle", "negative regulation of cargo loading into COPII vesicle", "down regulation of cargo loading into COPII-coated vesicle", "inhibition of protein sorting into COPII-coated vesicles", "downregulation of cargo loading into COPII-coated vesicle", "down-regulation of cargo loading into COPII-coated vesicle", "negative regulation of cargo selection into COPII-coated vesicle", "inhibition of cargo selection into COPII-coated vesicle"], "types": ["T043"], "canonical_name": "negative regulation of cargo loading into COPII-coated vesicle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cargo loading into a COPII-coated vesicle. [GOC:lb, GOC:TermGenie, PMID:15899885]"}
{"concept_id": "C3547426", "aliases": ["regulation of cargo selection into COPII-coated vesicle", "regulation of cargo loading into COPII vesicle"], "types": ["T043"], "canonical_name": "regulation of cargo loading into COPII-coated vesicle", "definition": "Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle. [GOC:lb, GOC:TermGenie, PMID:15899885]"}
{"concept_id": "C3547427", "aliases": ["up-regulation of hydrogen peroxide-mediated programmed cell death", "upregulation of hydrogen peroxide-mediated programmed cell death", "up regulation of hydrogen peroxide-mediated programmed cell death"], "types": ["T043"], "canonical_name": "positive regulation of hydrogen peroxide-mediated programmed cell death", "definition": "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547428", "aliases": ["down regulation of hydrogen peroxide-mediated programmed cell death", "downregulation of hydrogen peroxide-mediated programmed cell death", "down-regulation of hydrogen peroxide-mediated programmed cell death"], "types": ["T043"], "canonical_name": "negative regulation of hydrogen peroxide-mediated programmed cell death", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547429", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hydrogen peroxide-mediated programmed cell death", "definition": "Any process that modulates the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547430", "aliases": ["activation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "upregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "up regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "positive regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment", "upregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "up-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "up regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "positive regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "positive regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "activation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "up-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment"], "types": ["T044"], "canonical_name": "positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment", "definition": "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547431", "aliases": ["negative regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "down-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "downregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "down regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "inhibition of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "inhibition of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "down-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "negative regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment", "down regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment", "downregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment"], "types": ["T043"], "canonical_name": "negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547432", "aliases": ["regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment", "regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment", "regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment"], "types": ["T044"], "canonical_name": "regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment", "definition": "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547434", "aliases": ["nucleoside phosphate synthesis", "nucleoside phosphate biosynthesis", "nucleoside phosphate formation", "nucleoside phosphate anabolism"], "types": ["T044"], "canonical_name": "nucleoside phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. [GOC:TermGenie]"}
{"concept_id": "C3547435", "aliases": ["nucleoside phosphate degradation", "nucleoside phosphate catabolism", "nucleoside phosphate breakdown"], "types": ["T044"], "canonical_name": "nucleoside phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. [GOC:TermGenie]"}
{"concept_id": "C3547436", "aliases": ["down-regulation of double-strand break repair via single-strand annealing", "down regulation of double-strand break repair via single-strand annealing", "downregulation of double-strand break repair via single-strand annealing"], "types": ["T045"], "canonical_name": "negative regulation of double-strand break repair via single-strand annealing", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing. [GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3547437", "aliases": ["succinyl-CoA formation", "succinyl-CoA synthesis", "succinyl-CoA anabolism", "succinyl-CoA biosynthesis"], "types": ["T044"], "canonical_name": "succinyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of succinyl-CoA. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929]"}
{"concept_id": "C3547438", "aliases": ["succinyl-CoA catabolism", "succinyl-CoA degradation", "succinyl-CoA breakdown"], "types": ["T044"], "canonical_name": "succinyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of succinyl-CoA. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929]"}
{"concept_id": "C3547439", "aliases": ["iron-sulfur-molybdenum cofactor formation", "iron-molybdenum cofactor synthesis", "iron-molybdenum cofactor anabolism", "iron-sulfur-molybdenum cofactor anabolism", "FeMo-co formation", "FeMo-co biosynthetic process", "FeMo-co synthesis", "iron-molybdenum cofactor biosynthetic process", "FeMo-co anabolism", "iron-molybdenum cofactor formation", "iron-sulfur-molybdenum cofactor synthesis", "FeMo-co biosynthesis", "iron-molybdenum cofactor biosynthesis", "iron-sulfur-molybdenum cofactor biosynthesis"], "types": ["T044"], "canonical_name": "iron-sulfur-molybdenum cofactor biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782]"}
{"concept_id": "C3547440", "aliases": ["iron-molybdenum catabolism", "FeMo-co degradation", "iron-molybdenum catabolic process", "iron-sulfur-molybdenum cofactor degradation", "FeMo-co catabolic process", "FeMo-co breakdown", "iron-sulfur-molybdenum cofactor breakdown", "iron-molybdenum degradation", "iron-sulfur-molybdenum cofactor catabolism", "FeMo-co catabolism", "iron-molybdenum breakdown"], "types": ["T044"], "canonical_name": "iron-sulfur-molybdenum cofactor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of iron-sulfur-molybdenum cofactor. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782]"}
{"concept_id": "C3547441", "aliases": ["iron-molybdenum cofactor metabolism", "iron-molybdenum cofactor metabolic process", "iron-sulfur-molybdenum cofactor metabolism", "FeMo-co metabolic process", "FeMo-co metabolism"], "types": ["T044"], "canonical_name": "iron-sulfur-molybdenum cofactor metabolic process", "definition": "The chemical reactions and pathways involving iron-sulfur-molybdenum cofactor. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782]"}
{"concept_id": "C3547442", "aliases": ["5,6,7,8-tetrahydromethanopterin synthesis", "5,6,7,8-tetrahydromethanopterin biosynthesis", "5,6,7,8-tetrahydromethanopterin formation", "5,6,7,8-tetrahydromethanopterin anabolism"], "types": ["T044"], "canonical_name": "5,6,7,8-tetrahydromethanopterin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydromethanopterin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065]"}
{"concept_id": "C3547443", "aliases": ["5,6,7,8-tetrahydromethanopterin breakdown", "5,6,7,8-tetrahydromethanopterin catabolism", "5,6,7,8-tetrahydromethanopterin degradation"], "types": ["T044"], "canonical_name": "5,6,7,8-tetrahydromethanopterin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydromethanopterin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065]"}
{"concept_id": "C3547444", "aliases": ["5,6,7,8-tetrahydromethanopterin metabolism"], "types": ["T044"], "canonical_name": "5,6,7,8-tetrahydromethanopterin metabolic process", "definition": "The chemical reactions and pathways involving 5,6,7,8-tetrahydromethanopterin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065]"}
{"concept_id": "C3547445", "aliases": ["fructosyllysine biosynthesis", "fructosyllysine anabolism", "fructosyllysine biosynthetic process", "fructosyllysine formation", "fructosyllysine synthesis"], "types": ["T044"], "canonical_name": "fructoselysine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fructoselysine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784]"}
{"concept_id": "C3547446", "aliases": ["fructosyllysine breakdown", "fructosyllysine catabolic process", "fructosyllysine degradation", "fructosyllysine catabolism"], "types": ["T044"], "canonical_name": "fructoselysine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fructoselysine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784]"}
{"concept_id": "C3547447", "aliases": ["D-ribose 5-phosphate formation", "D-ribose 5-phosphate synthesis", "D-ribose 5-phosphate biosynthesis", "D-ribose 5-phosphate anabolism"], "types": ["T044"], "canonical_name": "D-ribose 5-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-ribose 5-phosphate. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293]"}
{"concept_id": "C3547448", "aliases": ["D-ribose 5-phosphate breakdown", "D-ribose 5-phosphate catabolism", "D-ribose 5-phosphate degradation"], "types": ["T044"], "canonical_name": "D-ribose 5-phosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-ribose 5-phosphate. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293]"}
{"concept_id": "C3547449", "aliases": ["D-ribose 5-phosphate metabolism"], "types": ["T044"], "canonical_name": "D-ribose 5-phosphate metabolic process", "definition": "The chemical reactions and pathways involving D-ribose 5-phosphate. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293]"}
{"concept_id": "C3547450", "aliases": ["tartrate anabolism", "tartrate formation", "tartrate biosynthesis", "tartrate synthesis"], "types": ["T044"], "canonical_name": "tartrate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tartrate. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839]"}
{"concept_id": "C3547451", "aliases": ["tartrate catabolism", "tartrate degradation", "tartrate breakdown"], "types": ["T044"], "canonical_name": "tartrate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tartrate. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839]"}
{"concept_id": "C3547452", "aliases": ["tartrate metabolism"], "types": ["T044"], "canonical_name": "tartrate metabolic process", "definition": "The chemical reactions and pathways involving tartrate. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839]"}
{"concept_id": "C3547453", "aliases": ["2-dehydro-3-deoxy-D-gluconic acid anabolism", "2-dehydro-3-deoxy-D-gluconic acid biosynthesis", "2-dehydro-3-deoxy-D-gluconic acid synthesis", "2-dehydro-3-deoxy-D-gluconic acid formation"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-D-gluconic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 2-dehydro-3-deoxy-D-gluconic acid. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856]"}
{"concept_id": "C3547454", "aliases": ["2-dehydro-3-deoxy-D-gluconic acid catabolism", "2-dehydro-3-deoxy-D-gluconic acid breakdown", "2-dehydro-3-deoxy-D-gluconic acid degradation"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-D-gluconic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-dehydro-3-deoxy-D-gluconic acid. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856]"}
{"concept_id": "C3547455", "aliases": ["2-dehydro-3-deoxy-D-gluconic acid metabolism"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-D-gluconic acid metabolic process", "definition": "The chemical reactions and pathways involving 2-dehydro-3-deoxy-D-gluconic acid. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856]"}
{"concept_id": "C3547456", "aliases": ["lipooligosaccharide biosynthesis", "lipooligosaccharide synthesis", "lipooligosaccharide formation", "lipooligosaccharide anabolism"], "types": ["T044"], "canonical_name": "lipooligosaccharide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lipooligosaccharide. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501]"}
{"concept_id": "C3547457", "aliases": ["lipooligosaccharide breakdown", "lipooligosaccharide catabolism", "lipooligosaccharide degradation"], "types": ["T044"], "canonical_name": "lipooligosaccharide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lipooligosaccharide. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501]"}
{"concept_id": "C3547458", "aliases": ["lipooligosaccharide metabolism"], "types": ["T044"], "canonical_name": "lipooligosaccharide metabolic process", "definition": "The chemical reactions and pathways involving lipooligosaccharide. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501]"}
{"concept_id": "C3547459", "aliases": ["cephalosporin C formation", "cephalosporin C anabolism", "cephalosporin C biosynthesis", "cephalosporin C synthesis"], "types": ["T044"], "canonical_name": "cephalosporin C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cephalosporin C. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172]"}
{"concept_id": "C3547460", "aliases": ["cephalosporin C breakdown", "cephalosporin C catabolism", "cephalosporin C degradation"], "types": ["T044"], "canonical_name": "cephalosporin C catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cephalosporin C. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172]"}
{"concept_id": "C3547461", "aliases": ["cephalosporin C metabolism"], "types": ["T044"], "canonical_name": "cephalosporin C metabolic process", "definition": "The chemical reactions and pathways involving cephalosporin C. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172]"}
{"concept_id": "C3547462", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside phosphate binding", "definition": "Binding to nucleoside phosphate. [GOC:TermGenie]"}
{"concept_id": "C3547463", "aliases": [], "types": ["T043"], "canonical_name": "carbohydrate derivative transport", "definition": "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3547464", "aliases": ["upregulation of sorocarp spore cell differentiation", "up-regulation of sorocarp spore cell differentiation", "up regulation of sorocarp spore cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of sorocarp spore cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of sorocarp spore cell differentiation. [GOC:rjd, GOC:TermGenie]"}
{"concept_id": "C3547465", "aliases": ["down regulation of sorocarp spore cell differentiation", "down-regulation of sorocarp spore cell differentiation", "downregulation of sorocarp spore cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of sorocarp spore cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sorocarp spore cell differentiation. [GOC:rjd, GOC:TermGenie]"}
{"concept_id": "C3547466", "aliases": [], "types": ["T040"], "canonical_name": "regulation of sorocarp spore cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of sorocarp spore cell differentiation. [GOC:rjd, GOC:TermGenie]"}
{"concept_id": "C3547467", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification", "definition": "Any peptidyl-lysine hydroxylation that is involved in bacterial-type EF-P lysine modification. [GOC:imk, GOC:TermGenie, PMID:22706199]"}
{"concept_id": "C3547468", "aliases": [], "types": ["T045"], "canonical_name": "chloroplast rRNA processing", "definition": "Any rRNA processing that takes place in chloroplast. [GOC:TermGenie]"}
{"concept_id": "C3547469", "aliases": ["upregulation of macrophage colony-stimulating factor production", "activation of M-CSF production", "up regulation of macrophage colony-stimulating factor production", "up-regulation of macrophage colony-stimulating factor production", "up regulation of M-CSF production", "upregulation of M-CSF production", "positive regulation of M-CSF production", "up-regulation of M-CSF production"], "types": ["T044"], "canonical_name": "positive regulation of macrophage colony-stimulating factor production", "definition": "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor production. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547470", "aliases": ["down-regulation of M-CSF production", "down regulation of M-CSF production", "down regulation of macrophage colony-stimulating factor production", "negative regulation of M-CSF production", "downregulation of macrophage colony-stimulating factor production", "inhibition of M-CSF production", "downregulation of M-CSF production", "down-regulation of macrophage colony-stimulating factor production"], "types": ["T044"], "canonical_name": "negative regulation of macrophage colony-stimulating factor production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor production. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547471", "aliases": ["regulation of M-CSF production"], "types": ["T039"], "canonical_name": "regulation of macrophage colony-stimulating factor production", "definition": "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor production. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547472", "aliases": ["NER involved in interstrand cross-link repair", "nucleotide-excision repair involved in ICL repair", "NER involved in ICL repair"], "types": ["T045"], "canonical_name": "nucleotide-excision repair involved in interstrand cross-link repair", "definition": "Any nucleotide-excision repair that is involved in interstrand cross-link repair. [GOC:TermGenie, PMID:22064477]"}
{"concept_id": "C3547473", "aliases": ["activation of movement of virus within host cell", "up regulation of movement of virus within host cell", "up-regulation of movement of virus within host cell", "upregulation of egress of virus within host cell", "upregulation of movement of virus within host cell", "up regulation of egress of virus within host cell", "positive regulation of movement of virus within host cell", "activation of viral egress", "positive regulation of viral egress", "positive regulation of egress of virus within host cell", "up-regulation of viral egress", "upregulation of viral egress", "up regulation of viral egress", "up-regulation of egress of virus within host cell"], "types": ["T038"], "canonical_name": "positive regulation of intracellular transport of viral material", "definition": "Any process that activates or increases the frequency, rate or extent of intracellular transport of viral material. [GOC:bf, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3547474", "aliases": ["inhibition of movement of virus within host cell", "down regulation of egress of virus within host cell", "inhibition of viral egress", "downregulation of viral egress", "negative regulation of viral egress", "down-regulation of viral egress", "downregulation of egress of virus within host cell", "down regulation of movement of virus within host cell", "down-regulation of movement of virus within host cell", "negative regulation of movement of virus within host cell", "down-regulation of egress of virus within host cell", "down regulation of viral egress", "downregulation of movement of virus within host cell", "negative regulation of egress of virus within host cell"], "types": ["T038"], "canonical_name": "negative regulation of intracellular transport of viral material", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material. [GOC:bf, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3547475", "aliases": ["regulation of viral egress", "regulation of egress of virus within host cell", "regulation of movement of virus within host cell"], "types": ["T038"], "canonical_name": "regulation of intracellular transport of viral material", "definition": "Any process that modulates the frequency, rate or extent of egress of virus within host cell. [GOC:bf, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3547476", "aliases": ["up-regulation of pulmonary goblet cell differentiation", "positive regulation of pulmonary goblet cell differentiation", "upregulation of pulmonary goblet cell differentiation", "up regulation of pulmonary goblet cell differentiation", "upregulation of lung goblet cell differentiation", "up regulation of lung goblet cell differentiation", "up-regulation of lung goblet cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of lung goblet cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of lung goblet cell differentiation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547477", "aliases": ["down regulation of pulmonary goblet cell differentiation", "downregulation of pulmonary goblet cell differentiation", "downregulation of lung goblet cell differentiation", "down-regulation of pulmonary goblet cell differentiation", "negative regulation of pulmonary goblet cell differentiation", "down regulation of lung goblet cell differentiation", "down-regulation of lung goblet cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of lung goblet cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547478", "aliases": ["regulation of pulmonary goblet cell differentiation"], "types": ["T043"], "canonical_name": "regulation of lung goblet cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of lung goblet cell differentiation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547479", "aliases": ["upregulation of lung ciliated cell differentiation", "up-regulation of lung ciliated cell differentiation", "up regulation of lung ciliated cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of lung ciliated cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547480", "aliases": ["downregulation of lung ciliated cell differentiation", "down regulation of lung ciliated cell differentiation", "down-regulation of lung ciliated cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of lung ciliated cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547481", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lung ciliated cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547484", "aliases": [], "types": ["T044"], "canonical_name": "doxorubicin transmembrane-transporting ATPase activity"}
{"concept_id": "C3547485", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetate transmembrane transporter activity", "definition": "Enables the transfer of 4-hydroxyphenylacetate from one side of a membrane to the other. [GOC:TermGenie, PMID:9315705]"}
{"concept_id": "C3547486", "aliases": [], "types": ["T044"], "canonical_name": "malonate(1-) transmembrane transporter activity", "definition": "Enables the transfer of malonate(1-) from one side of a membrane to the other. [GOC:TermGenie, PMID:9128730, PMID:9573154]"}
{"concept_id": "C3547487", "aliases": [], "types": ["T044"], "canonical_name": "tungstate transmembrane-transporting ATPase activity"}
{"concept_id": "C3547488", "aliases": [], "types": ["T044"], "canonical_name": "tungstate transmembrane transporter activity"}
{"concept_id": "C3547489", "aliases": [], "types": ["T044"], "canonical_name": "4-(trimethylammonio)butanoate transmembrane transporter activity", "definition": "Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other. [GOC:TermGenie, PMID:16952940, PMID:21784948]"}
{"concept_id": "C3547490", "aliases": [], "types": ["T044"], "canonical_name": "(R)-carnitine transmembrane transporter activity", "definition": "Enables the transfer of (R)-carnitine from one side of a membrane to the other. [GOC:TermGenie, PMID:16365042, PMID:20357772, PMID:20829798]"}
{"concept_id": "C3547491", "aliases": ["up regulation of convergent extension involved in axis elongation", "upregulation of convergent extension involved in axis elongation", "up-regulation of convergent extension involved in axis elongation"], "types": ["T038"], "canonical_name": "positive regulation of convergent extension involved in axis elongation", "definition": "Any process that activates or increases the frequency, rate or extent of convergent extension involved in axis elongation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547492", "aliases": ["downregulation of convergent extension involved in axis elongation", "down regulation of convergent extension involved in axis elongation", "down-regulation of convergent extension involved in axis elongation"], "types": ["T038"], "canonical_name": "negative regulation of convergent extension involved in axis elongation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in axis elongation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547493", "aliases": [], "types": ["T038"], "canonical_name": "regulation of convergent extension involved in axis elongation", "definition": "Any process that modulates the frequency, rate or extent of convergent extension involved in axis elongation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547494", "aliases": ["positive regulation of non-canonical Wnt-activated signaling pathway via JNK cascade", "up-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade", "positive regulation of non-canonical Wnt receptor signalling pathway via JNK cascade", "up-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade", "up regulation of non-canonical Wnt receptor signaling pathway via JNK cascade", "up regulation of non-canonical Wnt receptor signalling pathway via JNK cascade", "upregulation of non-canonical Wnt receptor signaling pathway via JNK cascade", "positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade", "upregulation of non-canonical Wnt receptor signalling pathway via JNK cascade"], "types": ["T044"], "canonical_name": "positive regulation of non-canonical Wnt signaling pathway via JNK cascade", "definition": "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547495", "aliases": ["downregulation of non-canonical Wnt receptor signaling pathway via JNK cascade", "down regulation of non-canonical Wnt receptor signalling pathway via JNK cascade", "negative regulation of non-canonical Wnt receptor signaling pathway via JNK cascade", "negative regulation of non-canonical Wnt receptor signalling pathway via JNK cascade", "down-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade", "downregulation of non-canonical Wnt receptor signalling pathway via JNK cascade", "down-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade", "down regulation of non-canonical Wnt receptor signaling pathway via JNK cascade"], "types": ["T044"], "canonical_name": "negative regulation of non-canonical Wnt signaling pathway via JNK cascade", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547496", "aliases": ["regulation of non-canonical Wnt receptor signaling pathway via JNK cascade", "regulation of non-canonical Wnt receptor signalling pathway via JNK cascade", "regulation of non-canonical Wnt-activated signaling pathway via JNK cascade"], "types": ["T044"], "canonical_name": "regulation of non-canonical Wnt signaling pathway via JNK cascade", "definition": "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547497", "aliases": ["positive regulation of NIK/NF-kappaB cascade", "upregulation of NIK/NF-kappaB cascade", "up regulation of NIK/NF-kappaB cascade", "up-regulation of NIK/NF-kappaB cascade"], "types": ["T044"], "canonical_name": "positive regulation of NIK/NF-kappaB signaling", "definition": "Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. [GOC:TermGenie]"}
{"concept_id": "C3547498", "aliases": ["down regulation of NIK/NF-kappaB cascade", "negative regulation of NIK/NF-kappaB cascade", "downregulation of NIK/NF-kappaB cascade", "down-regulation of NIK/NF-kappaB cascade"], "types": ["T044"], "canonical_name": "negative regulation of NIK/NF-kappaB signaling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling. [GOC:TermGenie]"}
{"concept_id": "C3547499", "aliases": ["regulation of NIK/NF-kappaB cascade"], "types": ["T044"], "canonical_name": "regulation of NIK/NF-kappaB signaling", "definition": "Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling. [GOC:TermGenie]"}
{"concept_id": "C3547500", "aliases": ["upregulation of heart chamber morphogenesis", "up regulation of cardiac chamber morphogenesis", "up regulation of heart chamber morphogenesis", "upregulation of cardiac chamber morphogenesis", "positive regulation of heart chamber morphogenesis", "up-regulation of cardiac chamber morphogenesis", "up-regulation of heart chamber morphogenesis"], "types": ["T039"], "canonical_name": "positive regulation of cardiac chamber morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547501", "aliases": ["negative regulation of heart chamber morphogenesis", "downregulation of heart chamber morphogenesis", "down-regulation of cardiac chamber morphogenesis", "downregulation of cardiac chamber morphogenesis", "down-regulation of heart chamber morphogenesis", "down regulation of heart chamber morphogenesis", "down regulation of cardiac chamber morphogenesis"], "types": ["T039"], "canonical_name": "negative regulation of cardiac chamber morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547502", "aliases": ["regulation of heart chamber morphogenesis"], "types": ["T042"], "canonical_name": "regulation of cardiac chamber morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547503", "aliases": ["antiholin activity", "down-regulation of holin activity", "downregulation of holin activity", "down regulation of holin activity"], "types": ["T039"], "canonical_name": "negative regulation of holin activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of holin activity. [GOC:bm, GOC:TermGenie]"}
{"concept_id": "C3547504", "aliases": [], "types": ["T040"], "canonical_name": "regulation of holin activity", "definition": "Any process that modulates the frequency, rate or extent of holin activity. [GOC:bm, GOC:TermGenie]"}
{"concept_id": "C3547505", "aliases": ["up regulation of neuronal cell death", "positive regulation of neuronal cell death", "up-regulation of neuron cell death", "up regulation of neuron death", "positive regulation of neuron cell death", "up regulation of neuron cell death", "upregulation of neuronal cell death", "upregulation of neuron death", "up-regulation of neuronal cell death", "upregulation of neuron cell death", "up-regulation of neuron death"], "types": ["T043"], "canonical_name": "positive regulation of neuron death", "definition": "Any process that activates or increases the frequency, rate or extent of neuron death. [GOC:rph, GOC:TermGenie]"}
{"concept_id": "C3547506", "aliases": ["negative regulation of neuronal cell death", "down regulation of neuron death", "downregulation of neuronal cell death", "down-regulation of neuron death", "downregulation of neuron death", "down-regulation of neuron cell death", "down regulation of neuron cell death", "downregulation of neuron cell death", "down-regulation of neuronal cell death", "negative regulation of neuron cell death", "down regulation of neuronal cell death"], "types": ["T043"], "canonical_name": "negative regulation of neuron death", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. [GOC:rph, GOC:TermGenie]"}
{"concept_id": "C3547507", "aliases": ["regulation of neuron cell death", "regulation of neuronal cell death"], "types": ["T043"], "canonical_name": "regulation of neuron death", "definition": "Any process that modulates the frequency, rate or extent of neuron death. [GOC:rph, GOC:TermGenie]"}
{"concept_id": "C3547509", "aliases": ["positive regulation of heart chamber formation", "upregulation of heart chamber formation", "activation of heart chamber formation", "up-regulation of cardiac chamber formation", "up regulation of heart chamber formation", "up-regulation of heart chamber formation", "upregulation of cardiac chamber formation", "up regulation of cardiac chamber formation"], "types": ["T039"], "canonical_name": "positive regulation of cardiac chamber formation", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547510", "aliases": ["negative regulation of heart chamber formation", "downregulation of heart chamber formation", "down-regulation of cardiac chamber formation", "inhibition of heart chamber formation", "down regulation of cardiac chamber formation", "downregulation of cardiac chamber formation", "down regulation of heart chamber formation", "down-regulation of heart chamber formation"], "types": ["T039"], "canonical_name": "negative regulation of cardiac chamber formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547511", "aliases": ["regulation of heart chamber formation"], "types": ["T042"], "canonical_name": "regulation of cardiac chamber formation", "definition": "Any process that modulates the frequency, rate or extent of cardiac chamber formation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547512", "aliases": ["upregulation of heart looping", "upregulation of cardiac looping", "up-regulation of heart looping", "up regulation of heart looping", "up regulation of cardiac looping", "activation of cardiac looping", "positive regulation of cardiac looping", "up-regulation of cardiac looping"], "types": ["T039"], "canonical_name": "positive regulation of heart looping", "definition": "Any process that activates or increases the frequency, rate or extent of heart looping. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547513", "aliases": ["down-regulation of heart looping", "down regulation of cardiac looping", "down regulation of heart looping", "downregulation of heart looping", "downregulation of cardiac looping", "negative regulation of cardiac looping", "down-regulation of cardiac looping", "inhibition of cardiac looping"], "types": ["T039"], "canonical_name": "negative regulation of heart looping", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of heart looping. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547514", "aliases": ["regulation of cardiac looping"], "types": ["T040"], "canonical_name": "regulation of heart looping", "definition": "Any process that modulates the frequency, rate or extent of heart looping. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547517", "aliases": ["up-regulation of extracellular matrix assembly", "up regulation of extracellular matrix assembly", "upregulation of extracellular matrix assembly"], "types": ["T043"], "canonical_name": "positive regulation of extracellular matrix assembly", "definition": "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547518", "aliases": ["down regulation of extracellular matrix assembly", "downregulation of extracellular matrix assembly", "down-regulation of extracellular matrix assembly"], "types": ["T043"], "canonical_name": "negative regulation of extracellular matrix assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547519", "aliases": [], "types": ["T043"], "canonical_name": "regulation of extracellular matrix assembly", "definition": "Any process that modulates the frequency, rate or extent of extracellular matrix assembly. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547520", "aliases": ["negative regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress", "negative regulation of calcium ion transport into cytosol involved in cellular salinity response"], "types": ["T043"], "canonical_name": "negative regulation of calcium ion transport into cytosol involved in cellular response to salt stress", "definition": "Any negative regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress. [GOC:TermGenie]"}
{"concept_id": "C3547521", "aliases": ["positive regulation of calcium ion transport into cytosol involved in cellular salinity response", "positive regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion transport into cytosol involved in cellular response to salt stress", "definition": "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress. [GOC:TermGenie]"}
{"concept_id": "C3547522", "aliases": ["positive regulation of calcium ion transport into cytosol involved in cellular response to Ca2+ ion"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion transport into cytosol involved in cellular response to calcium ion", "definition": "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to calcium ion. [GOC:TermGenie]"}
{"concept_id": "C3547523", "aliases": ["positive regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion", "upregulation of calcium-mediated signaling involved in cellular response to calcium ion", "upregulation of calcium-mediated signaling involved in cellular response to Ca2+ ion", "positive regulation of calcium-mediated signalling involved in cellular response to calcium ion", "up regulation of calcium-mediated signaling involved in cellular response to calcium ion", "up-regulation of calcium-mediated signaling involved in response to calcium ion", "positive regulation of calcium-mediated signalling involved in cellular response to Ca2+ ion", "up regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion", "up-regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion"], "types": ["T044"], "canonical_name": "positive regulation of calcium-mediated signaling involved in cellular response to calcium ion", "definition": "Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion. [GOC:TermGenie]"}
{"concept_id": "C3547524", "aliases": ["up-regulation of calcium-mediated signaling involved in cellular salinity response", "upregulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress", "up regulation of calcium-mediated signaling involved in cellular response to salt stress", "upregulation of calcium-mediated signaling involved in cellular response to salt stress", "positive regulation of calcium-mediated signalling involved in cellular response to salt stress", "upregulation of calcium-mediated signaling involved in cellular salinity response", "positive regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress", "up regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress", "up-regulation of calcium-mediated signaling involved in cellular response to salt stress", "up-regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress", "positive regulation of calcium-mediated signalling involved in cellular response to ionic osmotic stress", "positive regulation of calcium-mediated signalling involved in cellular salinity response", "positive regulation of calcium-mediated signaling involved in cellular salinity response", "up regulation of calcium-mediated signaling involved in cellular salinity response"], "types": ["T044"], "canonical_name": "positive regulation of calcium-mediated signaling involved in cellular response to salt stress", "definition": "Any positive regulation of calcium-mediated signaling that is involved in cellular response to salt stress. [GOC:TermGenie]"}
{"concept_id": "C3547525", "aliases": ["up-regulation of translation preinitiation complex assembly", "positive regulation of formation of translation pre-initiation complex", "up regulation of translation preinitiation complex assembly", "up regulation of formation of translation preinitiation complex", "activation of translation preinitiation complex assembly", "upregulation of formation of translation preinitiation complex", "upregulation of translation preinitiation complex assembly", "activation of formation of translation pre-initiation complex", "up-regulation of formation of translation preinitiation complex", "positive regulation of translation preinitiation complex assembly", "up regulation of formation of translation pre-initiation complex", "upregulation of formation of translation pre-initiation complex", "up-regulation of formation of translation pre-initiation complex"], "types": ["T045"], "canonical_name": "positive regulation of formation of translation preinitiation complex", "definition": "Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex. [GOC:TermGenie]"}
{"concept_id": "C3547526", "aliases": ["down-regulation of translation preinitiation complex assembly", "down regulation of formation of translation preinitiation complex", "negative regulation of translation preinitiation complex assembly", "down-regulation of formation of translation pre-initiation complex", "downregulation of formation of translation pre-initiation complex", "inhibition of formation of translation pre-initiation complex", "down-regulation of formation of translation preinitiation complex", "downregulation of translation preinitiation complex assembly", "downregulation of formation of translation preinitiation complex", "negative regulation of formation of translation pre-initiation complex", "down regulation of translation preinitiation complex assembly", "inhibition of translation preinitiation complex assembly", "down regulation of formation of translation pre-initiation complex"], "types": ["T045"], "canonical_name": "negative regulation of formation of translation preinitiation complex", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex. [GOC:TermGenie]"}
{"concept_id": "C3547527", "aliases": ["regulation of translation preinitiation complex assembly", "regulation of formation of translation pre-initiation complex"], "types": ["T045"], "canonical_name": "regulation of formation of translation preinitiation complex", "definition": "Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex. [GOC:TermGenie]"}
{"concept_id": "C3547528", "aliases": ["activation of translation initiation ternary complex assembly", "positive regulation of translation initiation ternary complex assembly", "up-regulation of formation of translation initiation ternary complex", "up-regulation of translation initiation ternary complex assembly", "up regulation of formation of translation initiation ternary complex", "upregulation of formation of translation initiation ternary complex", "up regulation of translation initiation ternary complex assembly", "upregulation of translation initiation ternary complex assembly"], "types": ["T045"], "canonical_name": "positive regulation of formation of translation initiation ternary complex", "definition": "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex. [GOC:TermGenie]"}
{"concept_id": "C3547529", "aliases": ["downregulation of formation of translation initiation ternary complex", "down-regulation of translation initiation ternary complex assembly", "negative regulation of translation initiation ternary complex assembly", "down regulation of formation of translation initiation ternary complex", "downregulation of translation initiation ternary complex assembly", "down regulation of translation initiation ternary complex assembly", "down-regulation of formation of translation initiation ternary complex", "inhibition of translation initiation ternary complex assembly"], "types": ["T045"], "canonical_name": "negative regulation of formation of translation initiation ternary complex", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. [GOC:TermGenie]"}
{"concept_id": "C3547530", "aliases": ["regulation of translation initiation ternary complex assembly"], "types": ["T045"], "canonical_name": "regulation of formation of translation initiation ternary complex", "definition": "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex. [GOC:TermGenie]"}
{"concept_id": "C3547531", "aliases": ["activation of Eph receptor signaling pathway", "up-regulation of Eph receptor signaling pathway", "upregulation of Eph receptor signaling pathway", "up regulation of Eph receptor signalling pathway", "up-regulation of Eph receptor signalling pathway", "positive regulation of Eph receptor signalling pathway", "up regulation of ephrin receptor signaling pathway", "upregulation of ephrin receptor signaling pathway", "positive regulation of Eph receptor signaling pathway", "upregulation of Eph receptor signalling pathway", "activation of Eph receptor signalling pathway", "up-regulation of ephrin receptor signaling pathway", "up regulation of Eph receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of ephrin receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547532", "aliases": ["down regulation of Eph receptor signaling pathway", "inhibition of Eph receptor signalling pathway", "downregulation of ephrin receptor signaling pathway", "negative regulation of Eph receptor signaling pathway", "downregulation of Eph receptor signalling pathway", "down-regulation of Eph receptor signalling pathway", "downregulation of Eph receptor signaling pathway", "down regulation of ephrin receptor signaling pathway", "down-regulation of Eph receptor signaling pathway", "down-regulation of ephrin receptor signaling pathway", "inhibition of Eph receptor signaling pathway", "down regulation of Eph receptor signalling pathway", "negative regulation of Eph receptor signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of ephrin receptor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ephrin receptor signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547533", "aliases": ["regulation of Eph receptor signalling pathway", "regulation of Eph receptor signaling pathway"], "types": ["T044"], "canonical_name": "regulation of ephrin receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of ephrin receptor signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547534", "aliases": ["activation of ErbB signaling", "upregulation of ERBB signalling pathway", "activation of ERBB signalling pathway", "activation of EGF receptor family signaling pathway", "up regulation of ErbB signaling", "up-regulation of ERBB signalling pathway", "upregulation of ErbB signaling", "upregulation of ERBB signaling pathway", "up regulation of ERBB signaling pathway", "up-regulation of ErbB signaling", "activation of ERBB signaling pathway", "up-regulation of ERBB signaling pathway", "up-regulation of EGF receptor family signaling pathway", "positive regulation of ERBB signalling pathway", "positive regulation of ErbB signaling", "upregulation of EGF receptor family signaling pathway", "up regulation of EGF receptor family signaling pathway", "up regulation of ERBB signalling pathway", "positive regulation of EGF receptor family signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of ERBB signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547535", "aliases": ["inhibition of ERBB signalling pathway", "inhibition of ErbB signaling", "down-regulation of ERBB signaling pathway", "downregulation of ErbB signaling", "inhibition of EGF receptor family signaling pathway", "inhibition of ERBB signaling pathway", "negative regulation of ErbB signaling", "down-regulation of ErbB signaling", "downregulation of EGF receptor family signaling pathway", "down regulation of ErbB signaling", "down regulation of ERBB signaling pathway", "down-regulation of ERBB signalling pathway", "down regulation of EGF receptor family signaling pathway", "negative regulation of EGF receptor family signaling pathway", "downregulation of ERBB signalling pathway", "negative regulation of ERBB signalling pathway", "downregulation of ERBB signaling pathway", "down-regulation of EGF receptor family signaling pathway", "down regulation of ERBB signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of ERBB signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547536", "aliases": ["regulation of ERBB signalling pathway", "regulation of ErbB signaling", "regulation of EGF receptor family signaling pathway"], "types": ["T044"], "canonical_name": "regulation of ERBB signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of ERBB signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547537", "aliases": ["positive regulation of camalexin synthesis", "up regulation of camalexin synthesis", "up regulation of camalexin formation", "up-regulation of camalexin biosynthesis", "positive regulation of camalexin anabolism", "upregulation of camalexin biosynthesis", "up-regulation of camalexin anabolism", "activation of camalexin biosynthesis", "up regulation of camalexin biosynthesis", "positive regulation of camalexin formation", "positive regulation of camalexin biosynthesis", "upregulation of camalexin formation", "upregulation of camalexin synthesis", "up regulation of camalexin biosynthetic process", "upregulation of camalexin anabolism", "up-regulation of camalexin formation", "upregulation of camalexin biosynthetic process", "activation of camalexin synthesis", "up-regulation of camalexin synthesis", "activation of camalexin formation", "up-regulation of camalexin biosynthetic process", "up regulation of camalexin anabolism", "activation of camalexin anabolism"], "types": ["T044"], "canonical_name": "positive regulation of camalexin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of camalexin biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547538", "aliases": ["regulation of camalexin anabolism", "regulation of camalexin biosynthesis", "regulation of camalexin formation", "regulation of camalexin synthesis"], "types": ["T044"], "canonical_name": "regulation of camalexin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of camalexin biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547539", "aliases": ["down regulation of cellular response to caffeine", "downregulation of cellular response to caffeine", "down-regulation of cellular response to caffeine"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to caffeine", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to caffeine. [GOC:TermGenie]"}
{"concept_id": "C3547540", "aliases": ["spheroidene biosynthesis", "spheroidene synthesis", "spheroidene anabolism", "spheroidene formation"], "types": ["T044"], "canonical_name": "spheroidene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of spheroidene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683]"}
{"concept_id": "C3547541", "aliases": ["spheroidene catabolism", "spheroidene degradation", "spheroidene breakdown"], "types": ["T044"], "canonical_name": "spheroidene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of spheroidene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683]"}
{"concept_id": "C3547542", "aliases": ["spheroidene metabolism"], "types": ["T044"], "canonical_name": "spheroidene metabolic process", "definition": "The chemical reactions and pathways involving spheroidene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683]"}
{"concept_id": "C3547543", "aliases": ["lycopene anabolism", "lycopene biosynthesis", "lycopene synthesis", "lycopene formation"], "types": ["T044"], "canonical_name": "lycopene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lycopene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803]"}
{"concept_id": "C3547544", "aliases": ["lycopene catabolism", "lycopene degradation", "lycopene breakdown"], "types": ["T044"], "canonical_name": "lycopene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lycopene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803]"}
{"concept_id": "C3547545", "aliases": ["lycopene metabolism"], "types": ["T044"], "canonical_name": "lycopene metabolic process", "definition": "The chemical reactions and pathways involving lycopene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803]"}
{"concept_id": "C3547546", "aliases": ["phytoene formation", "phytoene anabolism", "phytoene synthesis", "phytoene biosynthesis"], "types": ["T044"], "canonical_name": "phytoene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phytoene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799]"}
{"concept_id": "C3547547", "aliases": ["phytoene metabolism"], "types": ["T044"], "canonical_name": "phytoene metabolic process", "definition": "The chemical reactions and pathways involving phytoene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799]"}
{"concept_id": "C3547549", "aliases": ["naphthalene catabolism", "naphthalene breakdown", "naphthalene degradation"], "types": ["T044"], "canonical_name": "naphthalene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of naphthalene. [GOC:TermGenie, GOC:yaf, PMID:11133965]"}
{"concept_id": "C3547550", "aliases": ["3-chlorocatechol synthesis", "3-chlorocatechol biosynthesis", "3-chlorocatechol anabolism", "3-chlorocatechol formation"], "types": ["T044"], "canonical_name": "3-chlorocatechol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 3-chlorocatechol. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083]"}
{"concept_id": "C3547551", "aliases": ["3-chlorocatechol degradation", "3-chlorocatechol catabolism", "3-chlorocatechol breakdown"], "types": ["T044"], "canonical_name": "3-chlorocatechol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3-chlorocatechol. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083]"}
{"concept_id": "C3547552", "aliases": ["3-chlorocatechol metabolism"], "types": ["T044"], "canonical_name": "3-chlorocatechol metabolic process", "definition": "The chemical reactions and pathways involving 3-chlorocatechol. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083]"}
{"concept_id": "C3547553", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell migration involved in autonomic nervous system development", "definition": "Any neural crest cell migration that is involved in autonomic nervous system development. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547554", "aliases": ["up regulation of trophoblast cell migration", "upregulation of trophoblast cell migration", "up-regulation of trophoblast cell migration"], "types": ["T043"], "canonical_name": "positive regulation of trophoblast cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547555", "aliases": ["downregulation of trophoblast cell migration", "down regulation of trophoblast cell migration", "down-regulation of trophoblast cell migration"], "types": ["T043"], "canonical_name": "negative regulation of trophoblast cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547556", "aliases": [], "types": ["T043"], "canonical_name": "regulation of trophoblast cell migration", "definition": "Any process that modulates the frequency, rate or extent of trophoblast cell migration. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547557", "aliases": ["primary amino compound biosynthesis", "primary amino compound anabolism", "primary amino compound synthesis", "primary amino compound formation"], "types": ["T044"], "canonical_name": "primary amino compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of primary amino compound. [GOC:TermGenie]"}
{"concept_id": "C3547558", "aliases": ["primary amino compound degradation", "primary amino compound breakdown", "primary amino compound catabolism"], "types": ["T044"], "canonical_name": "primary amino compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of primary amino compound. [GOC:TermGenie]"}
{"concept_id": "C3547559", "aliases": ["primary amino compound metabolism"], "types": ["T040"], "canonical_name": "primary amino compound metabolic process", "definition": "The chemical reactions and pathways involving primary amino compound. [GOC:TermGenie]"}
{"concept_id": "C3547560", "aliases": ["xylulose 5-phosphate anabolism", "xylulose 5-phosphate formation", "xylulose 5-phosphate biosynthesis", "xylulose 5-phosphate synthesis"], "types": ["T044"], "canonical_name": "xylulose 5-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of xylulose 5-phosphate. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3547561", "aliases": ["neomycin synthesis", "neomycin formation", "neomycin anabolism", "neomycin biosynthesis"], "types": ["T044"], "canonical_name": "neomycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of neomycin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969]"}
{"concept_id": "C3547562", "aliases": ["neomycin catabolism", "neomycin degradation", "neomycin breakdown"], "types": ["T044"], "canonical_name": "neomycin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of neomycin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969]"}
{"concept_id": "C3547563", "aliases": ["neomycin metabolism"], "types": ["T044"], "canonical_name": "neomycin metabolic process", "definition": "The chemical reactions and pathways involving neomycin. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969]"}
{"concept_id": "C3547564", "aliases": ["paromomycin synthesis", "paromomycin biosynthesis", "paromomycin anabolism", "paromomycin formation"], "types": ["T044"], "canonical_name": "paromomycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of paromomycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970]"}
{"concept_id": "C3547565", "aliases": ["paromomycin degradation", "paromomycin catabolism", "paromomycin breakdown"], "types": ["T044"], "canonical_name": "paromomycin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of paromomycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970]"}
{"concept_id": "C3547566", "aliases": ["paromomycin metabolism"], "types": ["T044"], "canonical_name": "paromomycin metabolic process", "definition": "The chemical reactions and pathways involving paromomycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970]"}
{"concept_id": "C3547567", "aliases": ["ribostamycin anabolism", "vistamycin biosynthesis", "ribostamycin biosynthetic process", "vistamycin anabolism", "ribostamycin formation", "vistamycin formation", "ribostamycin biosynthesis", "ribostamycin synthesis", "vistamycin synthesis"], "types": ["T044"], "canonical_name": "vistamycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of vistamycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972]"}
{"concept_id": "C3547568", "aliases": ["vistamycin degradation", "vistamycin breakdown", "vistamycin catabolism", "ribostamycin degradation", "ribostamycin catabolic process", "ribostamycin catabolism", "ribostamycin breakdown"], "types": ["T044"], "canonical_name": "vistamycin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of vistamycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972]"}
{"concept_id": "C3547569", "aliases": ["ribostamycin metabolic process", "ribostamycin metabolism", "vistamycin metabolism"], "types": ["T044"], "canonical_name": "vistamycin metabolic process", "definition": "The chemical reactions and pathways involving vistamycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972]"}
{"concept_id": "C3547570", "aliases": [], "types": ["T044"], "canonical_name": "salicylic acid binding", "definition": "Binding to salicylic acid. [GOC:TermGenie, PMID:22699612]"}
{"concept_id": "C3547571", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis", "definition": "Any mesenchymal cell apoptotic process that is involved in metanephric nephron morphogenesis. [GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3547572", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis", "definition": "Any mesenchymal cell apoptotic process that is involved in mesonephric nephron morphogenesis. [GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3547573", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell apoptotic process involved in nephron morphogenesis", "definition": "Any mesenchymal cell apoptotic process that is involved in nephron morphogenesis. [GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3547574", "aliases": ["insulin degradation", "insulin catabolism", "insulin breakdown"], "types": ["T044"], "canonical_name": "insulin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of insulin. [GOC:TermGenie]"}
{"concept_id": "C3547575", "aliases": ["insulin metabolism"], "types": ["T044"], "canonical_name": "insulin metabolic process", "definition": "The chemical reactions and pathways involving insulin. [GOC:TermGenie]"}
{"concept_id": "C3547576", "aliases": ["regulation of lignin biosynthesis", "regulation of lignin anabolism", "regulation of lignin formation", "regulation of lignin synthesis"], "types": ["T044"], "canonical_name": "regulation of lignin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of lignin biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3547577", "aliases": ["4-hydroxycinnamyl alcohol transport"], "types": ["T043"], "canonical_name": "p-coumaryl alcohol transport", "definition": "The directed movement of a p-coumaryl alcohol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie]"}
{"concept_id": "C3547580", "aliases": ["carbohydrate derivative anabolism", "carbohydrate derivative formation", "carbohydrate derivative biosynthesis", "carbohydrate derivative synthesis"], "types": ["T044"], "canonical_name": "carbohydrate derivative biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of carbohydrate derivative. [GOC:TermGenie]"}
{"concept_id": "C3547581", "aliases": ["carbohydrate derivative breakdown", "carbohydrate derivative degradation", "carbohydrate derivative catabolism"], "types": ["T044"], "canonical_name": "carbohydrate derivative catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. [GOC:TermGenie]"}
{"concept_id": "C3547582", "aliases": ["carbohydrate derivative metabolism"], "types": ["T044"], "canonical_name": "carbohydrate derivative metabolic process", "definition": "The chemical reactions and pathways involving carbohydrate derivative. [GOC:TermGenie]"}
{"concept_id": "C3547584", "aliases": ["kanamycin synthesis", "kanamycin formation", "kanamycin anabolism", "kanamycin biosynthesis"], "types": ["T044"], "canonical_name": "kanamycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of kanamycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965]"}
{"concept_id": "C3547585", "aliases": ["kanamycin catabolism", "kanamycin degradation", "kanamycin breakdown"], "types": ["T044"], "canonical_name": "kanamycin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of kanamycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965]"}
{"concept_id": "C3547586", "aliases": ["kanamycin metabolism"], "types": ["T044"], "canonical_name": "kanamycin metabolic process", "definition": "The chemical reactions and pathways involving kanamycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965]"}
{"concept_id": "C3547587", "aliases": ["gentamycin anabolism", "gentamycin synthesis", "gentamycin formation", "gentamycin biosynthesis"], "types": ["T044"], "canonical_name": "gentamycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of gentamycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967]"}
{"concept_id": "C3547588", "aliases": ["gentamycin catabolism", "gentamycin degradation", "gentamycin breakdown"], "types": ["T044"], "canonical_name": "gentamycin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of gentamycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967]"}
{"concept_id": "C3547589", "aliases": ["gentamycin metabolism"], "types": ["T044"], "canonical_name": "gentamycin metabolic process", "definition": "The chemical reactions and pathways involving gentamycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967]"}
{"concept_id": "C3547590", "aliases": ["candicidin anabolism", "candicidin synthesis", "candicidin formation", "candicidin biosynthesis"], "types": ["T044"], "canonical_name": "candicidin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of candicidin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]"}
{"concept_id": "C3547591", "aliases": ["candicidin degradation", "candicidin catabolism", "candicidin breakdown"], "types": ["T044"], "canonical_name": "candicidin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of candicidin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]"}
{"concept_id": "C3547592", "aliases": ["candicidin metabolism"], "types": ["T044"], "canonical_name": "candicidin metabolic process", "definition": "The chemical reactions and pathways involving candicidin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]"}
{"concept_id": "C3547593", "aliases": ["bacitracin A synthesis", "bacitracin A anabolism", "bacitracin A formation", "bacitracin A biosynthesis"], "types": ["T044"], "canonical_name": "bacitracin A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of bacitracin A. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]"}
{"concept_id": "C3547594", "aliases": ["bacitracin A degradation", "bacitracin A catabolism", "bacitracin A breakdown"], "types": ["T044"], "canonical_name": "bacitracin A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of bacitracin A. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]"}
{"concept_id": "C3547595", "aliases": ["bacitracin A metabolism"], "types": ["T044"], "canonical_name": "bacitracin A metabolic process", "definition": "The chemical reactions and pathways involving bacitracin A. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]"}
{"concept_id": "C3547596", "aliases": ["tobramycin biosynthesis", "tobramycin anabolism", "tobramycin formation", "tobramycin synthesis"], "types": ["T044"], "canonical_name": "tobramycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tobramycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]"}
{"concept_id": "C3547597", "aliases": ["tobramycin degradation", "tobramycin breakdown", "tobramycin catabolism"], "types": ["T044"], "canonical_name": "tobramycin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tobramycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]"}
{"concept_id": "C3547598", "aliases": ["tobramycin metabolism"], "types": ["T044"], "canonical_name": "tobramycin metabolic process", "definition": "The chemical reactions and pathways involving tobramycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]"}
{"concept_id": "C3547599", "aliases": ["cephamycin C anabolism", "cephamycin C synthesis", "cephamycin C biosynthesis", "cephamycin C formation"], "types": ["T044"], "canonical_name": "cephamycin C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cephamycin C. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183]"}
{"concept_id": "C3547600", "aliases": ["cephamycin C catabolism", "cephamycin C degradation", "cephamycin C breakdown"], "types": ["T044"], "canonical_name": "cephamycin C catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cephamycin C. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183]"}
{"concept_id": "C3547601", "aliases": ["cephamycin C metabolism"], "types": ["T044"], "canonical_name": "cephamycin C metabolic process", "definition": "The chemical reactions and pathways involving cephamycin C. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183]"}
{"concept_id": "C3547602", "aliases": ["erythromycin biosynthesis", "erythromycin formation", "erythromycin synthesis", "erythromycin anabolism"], "types": ["T044"], "canonical_name": "erythromycin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of erythromycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]"}
{"concept_id": "C3547603", "aliases": ["erythromycin degradation", "erythromycin catabolism", "erythromycin breakdown"], "types": ["T044"], "canonical_name": "erythromycin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of erythromycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]"}
{"concept_id": "C3547604", "aliases": ["erythromycin metabolism"], "types": ["T044"], "canonical_name": "erythromycin metabolic process", "definition": "The chemical reactions and pathways involving erythromycin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]"}
{"concept_id": "C3547605", "aliases": ["actinorhodin biosynthesis", "actinorhodin synthesis", "actinorhodin formation", "actinorhodin anabolism"], "types": ["T044"], "canonical_name": "actinorhodin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of actinorhodin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]"}
{"concept_id": "C3547606", "aliases": ["actinorhodin degradation", "actinorhodin catabolism", "actinorhodin breakdown"], "types": ["T044"], "canonical_name": "actinorhodin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of actinorhodin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]"}
{"concept_id": "C3547607", "aliases": ["actinorhodin metabolism"], "types": ["T044"], "canonical_name": "actinorhodin metabolic process", "definition": "The chemical reactions and pathways involving actinorhodin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]"}
{"concept_id": "C3547608", "aliases": ["granaticin formation", "granaticin anabolism", "granaticin biosynthesis", "granaticin synthesis"], "types": ["T044"], "canonical_name": "granaticin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of granaticin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]"}
{"concept_id": "C3547609", "aliases": ["granaticin catabolism", "granaticin breakdown", "granaticin degradation"], "types": ["T044"], "canonical_name": "granaticin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of granaticin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]"}
{"concept_id": "C3547610", "aliases": ["granaticin metabolism"], "types": ["T044"], "canonical_name": "granaticin metabolic process", "definition": "The chemical reactions and pathways involving granaticin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]"}
{"concept_id": "C3547611", "aliases": ["tetracenomycin C formation", "tetracenomycin C biosynthesis", "tetracenomycin C synthesis", "tetracenomycin C anabolism"], "types": ["T044"], "canonical_name": "tetracenomycin C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tetracenomycin C. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]"}
{"concept_id": "C3547612", "aliases": ["tetracenomycin C catabolism", "tetracenomycin C degradation", "tetracenomycin C breakdown"], "types": ["T044"], "canonical_name": "tetracenomycin C catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tetracenomycin C. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]"}
{"concept_id": "C3547613", "aliases": ["tetracenomycin C metabolism"], "types": ["T044"], "canonical_name": "tetracenomycin C metabolic process", "definition": "The chemical reactions and pathways involving tetracenomycin C. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]"}
{"concept_id": "C3547614", "aliases": ["gramicidin S anabolism", "gramicidin S biosynthesis", "gramicidin S synthesis", "gramicidin S formation"], "types": ["T044"], "canonical_name": "gramicidin S biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of gramicidin S. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102]"}
{"concept_id": "C3547615", "aliases": ["gramicidin S degradation", "gramicidin S catabolism", "gramicidin S breakdown"], "types": ["T044"], "canonical_name": "gramicidin S catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of gramicidin S. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102]"}
{"concept_id": "C3547616", "aliases": ["gramicidin S metabolism"], "types": ["T044"], "canonical_name": "gramicidin S metabolic process", "definition": "The chemical reactions and pathways involving gramicidin S. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102]"}
{"concept_id": "C3547617", "aliases": ["down regulation of signal transduction in absence of agonist", "downregulation of signal transduction in absence of ligand", "downregulation of signal transduction in absence of agonist", "negative regulation of signal transduction in absence of agonist", "down regulation of signal transduction in absence of ligand", "down-regulation of signal transduction in absence of agonist", "down-regulation of signal transduction in absence of ligand"], "types": ["T044"], "canonical_name": "negative regulation of signal transduction in absence of ligand", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand. [GOC:TermGenie]"}
{"concept_id": "C3547618", "aliases": ["up-regulation of autophagic vacuole fusion", "up regulation of autophagic vacuole fusion", "up regulation of autophagic vacuole maturation", "positive regulation of autophagic vacuole fusion", "positive regulation of autophagosome fusion", "upregulation of autophagic vacuole maturation", "up-regulation of autophagosome maturation", "up-regulation of autophagic vacuole maturation", "upregulation of autophagic vacuole fusion", "activation of autophagosome maturation", "up regulation of autophagosome maturation", "upregulation of autophagosome maturation"], "types": ["T043"], "canonical_name": "positive regulation of autophagosome maturation", "definition": "Any process that activates or increases the frequency, rate or extent of autophagosome maturation. [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]"}
{"concept_id": "C3547619", "aliases": ["down regulation of autophagosome maturation", "down regulation of autophagic vacuole fusion", "negative regulation of autophagic vacuole fusion", "down-regulation of autophagosome maturation", "downregulation of autophagic vacuole fusion", "inhibition of autophagosome maturation", "downregulation of autophagic vacuole maturation", "down regulation of autophagic vacuole maturation", "down-regulation of autophagic vacuole fusion", "negative regulation of autophagosome fusion", "downregulation of autophagosome maturation", "down-regulation of autophagic vacuole maturation"], "types": ["T043"], "canonical_name": "negative regulation of autophagosome maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation. [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]"}
{"concept_id": "C3547620", "aliases": ["regulation of autophagosome fusion", "regulation of autophagic vacuole fusion"], "types": ["T038"], "canonical_name": "regulation of autophagosome maturation", "definition": "Any process that modulates the frequency, rate or extent of autophagosome maturation. [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]"}
{"concept_id": "C3547621", "aliases": ["upregulation of protein homotetramer formation", "upregulation of protein homotetramerization", "positive regulation of protein homotetramer assembly", "up-regulation of protein homotetramerization", "up regulation of protein homotetramer assembly", "up-regulation of protein homotetramer biosynthesis", "up regulation of protein homotetramerization", "positive regulation of protein homotetramer formation", "up regulation of protein homotetramer biosynthesis", "positive regulation of protein homotetramer biosynthesis", "upregulation of protein homotetramer biosynthetic process", "up-regulation of protein homotetramer formation", "up regulation of protein homotetramer biosynthetic process", "up-regulation of protein homotetramer assembly", "positive regulation of protein homotetramer biosynthetic process", "up regulation of protein homotetramer formation", "up-regulation of protein homotetramer biosynthetic process", "upregulation of protein homotetramer biosynthesis", "upregulation of protein homotetramer assembly"], "types": ["T043"], "canonical_name": "positive regulation of protein homotetramerization", "definition": "Any process that activates or increases the frequency, rate or extent of protein homotetramerization. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3547622", "aliases": ["negative regulation of protein homotetramer biosynthesis", "negative regulation of protein homotetramer assembly", "down regulation of protein homotetramer formation", "down-regulation of protein homotetramer formation", "down-regulation of protein homotetramerization", "downregulation of protein homotetramer formation", "downregulation of protein homotetramer biosynthesis", "negative regulation of protein homotetramer biosynthetic process", "down regulation of protein homotetramer assembly", "down regulation of protein homotetramer biosynthetic process", "down regulation of protein homotetramer biosynthesis", "down regulation of protein homotetramerization", "down-regulation of protein homotetramer assembly", "downregulation of protein homotetramerization", "down-regulation of protein homotetramer biosynthetic process", "downregulation of protein homotetramer assembly", "downregulation of protein homotetramer biosynthetic process", "negative regulation of protein homotetramer formation", "down-regulation of protein homotetramer biosynthesis"], "types": ["T043"], "canonical_name": "negative regulation of protein homotetramerization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein homotetramerization. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3547623", "aliases": ["regulation of protein homotetramer formation", "regulation of protein homotetramer biosynthetic process", "regulation of protein homotetramer assembly", "regulation of protein homotetramer biosynthesis"], "types": ["T040"], "canonical_name": "regulation of protein homotetramerization", "definition": "Any process that modulates the frequency, rate or extent of protein homotetramerization. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3547624", "aliases": ["positive regulation of protein tetramer biosynthetic process", "up-regulation of protein tetramer assembly", "upregulation of protein tetramerization", "up regulation of protein tetramer assembly", "upregulation of protein tetramer formation", "up-regulation of protein tetramer biosynthesis", "up-regulation of protein tetramer formation", "upregulation of protein tetramer biosynthetic process", "positive regulation of protein tetramer assembly", "up regulation of protein tetramerization", "up regulation of protein tetramer biosynthesis", "upregulation of protein tetramer assembly", "positive regulation of protein tetramer formation", "upregulation of protein tetramer biosynthesis", "positive regulation of protein tetramer biosynthesis", "up-regulation of protein tetramer biosynthetic process", "up regulation of protein tetramer biosynthetic process", "up-regulation of protein tetramerization", "up regulation of protein tetramer formation"], "types": ["T043"], "canonical_name": "positive regulation of protein tetramerization", "definition": "Any process that activates or increases the frequency, rate or extent of protein tetramerization. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3547625", "aliases": ["down regulation of protein tetramerization", "downregulation of protein tetramer biosynthetic process", "negative regulation of protein tetramer biosynthetic process", "negative regulation of protein tetramer biosynthesis", "down regulation of protein tetramer formation", "down-regulation of protein tetramerization", "downregulation of protein tetramer formation", "downregulation of protein tetramerization", "downregulation of protein tetramer assembly", "negative regulation of protein tetramer assembly", "down-regulation of protein tetramer biosynthetic process", "downregulation of protein tetramer biosynthesis", "down regulation of protein tetramer assembly", "negative regulation of protein tetramer formation", "down-regulation of protein tetramer biosynthesis", "down regulation of protein tetramer biosynthesis", "down-regulation of protein tetramer formation", "down regulation of protein tetramer biosynthetic process", "down-regulation of protein tetramer assembly"], "types": ["T043"], "canonical_name": "negative regulation of protein tetramerization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein tetramerization. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3547626", "aliases": ["regulation of protein tetramer formation", "regulation of protein tetramer assembly", "regulation of protein tetramer biosynthesis", "regulation of protein tetramer biosynthetic process"], "types": ["T040"], "canonical_name": "regulation of protein tetramerization", "definition": "Any process that modulates the frequency, rate or extent of protein tetramerization. [GOC:pm, GOC:TermGenie]"}
{"concept_id": "C3547627", "aliases": ["acetate ester metabolic process during fermentation"], "types": ["T040"], "canonical_name": "acetate ester metabolic process involved in fermentation", "definition": "Any acetate ester metabolic process that is involved in fermentation. [GOC:sgd_curators, GOC:TermGenie]"}
{"concept_id": "C3547628", "aliases": ["benzylpenicillin biosynthesis", "benzylpenicillin synthesis", "penicillin G anabolism", "penicillin G biosynthesis", "benzylpenicillin anabolism", "penicillin G synthesis", "penicillin G formation", "benzylpenicillin formation"], "types": ["T044"], "canonical_name": "benzylpenicillin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of benzylpenicillin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149]"}
{"concept_id": "C3547629", "aliases": ["penicillin G degradation", "benzylpenicillin breakdown", "benzylpenicillin catabolism", "penicillin G catabolism", "penicillin G breakdown", "penicillin G catabolic process", "benzylpenicillin degradation"], "types": ["T044"], "canonical_name": "benzylpenicillin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of benzylpenicillin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149]"}
{"concept_id": "C3547630", "aliases": ["penicillin G metabolism", "benzylpenicillin metabolism"], "types": ["T044"], "canonical_name": "benzylpenicillin metabolic process", "definition": "The chemical reactions and pathways involving benzylpenicillin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149]"}
{"concept_id": "C3547631", "aliases": ["pyrrolizidine alkaloid formation", "pyrrolizidine alkaloid synthesis", "pyrrolizidine alkaloid biosynthesis", "pyrrolizidine alkaloid anabolism"], "types": ["T044"], "canonical_name": "pyrrolizidine alkaloid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrrolizidine alkaloid. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329]"}
{"concept_id": "C3547632", "aliases": ["pyrrolizidine alkaloid breakdown", "pyrrolizidine alkaloid catabolism", "pyrrolizidine alkaloid degradation"], "types": ["T044"], "canonical_name": "pyrrolizidine alkaloid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pyrrolizidine alkaloid. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329]"}
{"concept_id": "C3547633", "aliases": ["pyrrolizidine alkaloid metabolism"], "types": ["T044"], "canonical_name": "pyrrolizidine alkaloid metabolic process", "definition": "The chemical reactions and pathways involving pyrrolizidine alkaloid. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329]"}
{"concept_id": "C3547634", "aliases": ["activation of smooth muscle relaxation", "up regulation of smooth muscle relaxation", "activation of relaxation of smooth muscle", "up-regulation of smooth muscle relaxation", "upregulation of relaxation of smooth muscle", "upregulation of smooth muscle relaxation", "up-regulation of relaxation of smooth muscle", "up regulation of relaxation of smooth muscle", "positive regulation of smooth muscle relaxation"], "types": ["T039"], "canonical_name": "positive regulation of relaxation of smooth muscle", "definition": "Any process that activates or increases the frequency, rate or extent of relaxation of smooth muscle. [GOC:TermGenie]"}
{"concept_id": "C3547635", "aliases": ["inhibition of smooth muscle relaxation", "down-regulation of relaxation of smooth muscle", "negative regulation of smooth muscle relaxation", "inhibition of relaxation of smooth muscle", "down regulation of smooth muscle relaxation", "downregulation of relaxation of smooth muscle", "downregulation of smooth muscle relaxation", "down-regulation of smooth muscle relaxation", "down regulation of relaxation of smooth muscle"], "types": ["T039"], "canonical_name": "negative regulation of relaxation of smooth muscle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of smooth muscle. [GOC:TermGenie]"}
{"concept_id": "C3547636", "aliases": ["regulation of smooth muscle relaxation"], "types": ["T042"], "canonical_name": "regulation of relaxation of smooth muscle", "definition": "Any process that modulates the frequency, rate or extent of relaxation of smooth muscle. [GOC:TermGenie]"}
{"concept_id": "C3547637", "aliases": ["up-regulation of relaxation of muscle", "up regulation of relaxation of muscle", "upregulation of relaxation of muscle"], "types": ["T039"], "canonical_name": "positive regulation of relaxation of muscle", "definition": "Any process that activates or increases the frequency, rate or extent of relaxation of muscle. [GOC:TermGenie]"}
{"concept_id": "C3547638", "aliases": ["down-regulation of relaxation of muscle", "downregulation of relaxation of muscle", "down regulation of relaxation of muscle"], "types": ["T039"], "canonical_name": "negative regulation of relaxation of muscle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle. [GOC:TermGenie]"}
{"concept_id": "C3547639", "aliases": [], "types": ["T042"], "canonical_name": "regulation of relaxation of muscle", "definition": "Any process that modulates the frequency, rate or extent of relaxation of muscle. [GOC:TermGenie]"}
{"concept_id": "C3547640", "aliases": ["positive regulation of engulfment of apoptotic cell corpse", "upregulation of engulfment of cell corpse", "up regulation of engulfment of apoptotic cell", "upregulation of engulfment of apoptotic cell", "positive regulation of engulfment of cell corpse", "up-regulation of engulfment of cell corpse", "up regulation of engulfment of apoptotic cell corpse", "upregulation of engulfment of apoptotic cell corpse", "up regulation of engulfment of cell corpse", "up-regulation of engulfment of apoptotic cell corpse", "up-regulation of engulfment of apoptotic cell"], "types": ["T040"], "canonical_name": "positive regulation of engulfment of apoptotic cell", "definition": "Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell. [GO:kmv, GOC:TermGenie, PMID:19402756]"}
{"concept_id": "C3547641", "aliases": ["negative regulation of engulfment of apoptotic cell corpse", "down regulation of engulfment of apoptotic cell", "downregulation of engulfment of cell corpse", "down-regulation of engulfment of apoptotic cell", "downregulation of engulfment of apoptotic cell", "down-regulation of engulfment of apoptotic cell corpse", "down-regulation of engulfment of cell corpse", "downregulation of engulfment of apoptotic cell corpse", "negative regulation of engulfment of cell corpse", "down regulation of engulfment of apoptotic cell corpse", "down regulation of engulfment of cell corpse"], "types": ["T043"], "canonical_name": "negative regulation of engulfment of apoptotic cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of engulfment of apoptotic cell. [GO:kmv, GOC:TermGenie, PMID:19402756]"}
{"concept_id": "C3547642", "aliases": ["regulation of engulfment of apoptotic cell corpse", "regulation of engulfment of cell corpse"], "types": ["T043"], "canonical_name": "regulation of engulfment of apoptotic cell", "definition": "Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell. [GO:kmv, GOC:TermGenie, PMID:19402756]"}
{"concept_id": "C3547643", "aliases": ["glucosamine-containing compound formation", "glucosamines biosynthetic process", "glucosamine-containing compound anabolism", "glucosamines anabolism", "glucosamines synthesis", "glucosamine-containing compound synthesis", "glucosamine-containing compound biosynthesis", "glucosamines biosynthesis", "glucosamines formation"], "types": ["T044"], "canonical_name": "glucosamine-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glucosamine-containing compounds (glucosamines). [GOC:TermGenie]"}
{"concept_id": "C3547644", "aliases": ["glucosamines breakdown", "glucosamine-containing compound catabolism", "glucosamines catabolic process", "glucosamine-containing compound degradation", "glucosamine-containing compound breakdown", "glucosamines degradation", "glucosamines catabolism"], "types": ["T044"], "canonical_name": "glucosamine-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds (glucosamines). [GOC:TermGenie]"}
{"concept_id": "C3547646", "aliases": ["guanosine-containing compound anabolism", "guanosine-containing compound formation", "guanosines formation", "guanosines anabolism", "guanosines synthesis", "guanosines biosynthetic process", "guanosine-containing compound biosynthesis", "guanosine-containing compound synthesis", "guanosines biosynthesis"], "types": ["T044"], "canonical_name": "guanosine-containing compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines). [GOC:TermGenie]"}
{"concept_id": "C3547647", "aliases": ["guanosine-containing compound degradation", "guanosines catabolic process", "guanosine-containing compound catabolism", "guanosines breakdown", "guanosines catabolism", "guanosines degradation", "guanosine-containing compound breakdown"], "types": ["T044"], "canonical_name": "guanosine-containing compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines). [GOC:TermGenie]"}
{"concept_id": "C3547648", "aliases": ["guanosines metabolism", "guanosines metabolic process", "guanosine-containing compound metabolism"], "types": ["T044"], "canonical_name": "guanosine-containing compound metabolic process", "definition": "The chemical reactions and pathways involving guanosine-containing compounds (guanosines). [GOC:TermGenie]"}
{"concept_id": "C3547649", "aliases": ["ferulate breakdown", "ferulate degradation", "ferulate catabolism"], "types": ["T044"], "canonical_name": "ferulate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ferulate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547650", "aliases": ["syringal lignin synthesis", "syringal lignin formation", "S-lignin biosynthetic process", "syringal lignin anabolism", "syringal lignin biosynthesis"], "types": ["T044"], "canonical_name": "syringal lignin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of syringal lignin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547651", "aliases": ["syringal lignin catabolism", "syringal lignin degradation", "syringal lignin breakdown", "S-lignin catabolic process"], "types": ["T044"], "canonical_name": "syringal lignin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of syringal lignin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547652", "aliases": ["syringal lignin metabolism", "S-lignin metabolic process"], "types": ["T044"], "canonical_name": "syringal lignin metabolic process", "definition": "The chemical reactions and pathways involving syringal lignin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547653", "aliases": ["guaiacyl lignin formation", "G-lignin biosynthetic process", "guaiacyl lignin synthesis", "guaiacyl lignin biosynthesis", "guaiacyl lignin anabolism"], "types": ["T044"], "canonical_name": "guaiacyl lignin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of guaiacyl lignin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547654", "aliases": ["G-lignin catabolic process", "guaiacyl lignin breakdown", "guaiacyl lignin degradation", "guaiacyl lignin catabolism"], "types": ["T044"], "canonical_name": "guaiacyl lignin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of guaiacyl lignin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547655", "aliases": ["guaiacyl lignin metabolism", "G-lignin metabolic process"], "types": ["T044"], "canonical_name": "guaiacyl lignin metabolic process", "definition": "The chemical reactions and pathways involving guaiacyl lignin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547656", "aliases": ["p-hydroxyphenyl lignin formation", "p-hydroxyphenyl lignin synthesis", "p-hydroxyphenyl lignin anabolism", "p-hydroxyphenyl lignin biosynthesis", "H-lignin biosynthetic process"], "types": ["T044"], "canonical_name": "p-hydroxyphenyl lignin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of p-hydroxyphenyl lignin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547657", "aliases": ["p-hydroxyphenyl lignin degradation", "p-hydroxyphenyl lignin breakdown", "p-hydroxyphenyl lignin catabolism", "H-lignin catabolic process"], "types": ["T044"], "canonical_name": "p-hydroxyphenyl lignin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of p-hydroxyphenyl lignin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547658", "aliases": ["p-hydroxyphenyl lignin metabolism", "H-lignin metabolic process"], "types": ["T044"], "canonical_name": "p-hydroxyphenyl lignin metabolic process", "definition": "The chemical reactions and pathways involving p-hydroxyphenyl lignin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547659", "aliases": ["trimethylenediamine biosynthesis", "trimethylenediamine synthesis", "trimethylenediamine formation", "trimethylenediamine anabolism"], "types": ["T044"], "canonical_name": "trimethylenediamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of trimethylenediamine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010]"}
{"concept_id": "C3547660", "aliases": ["trimethylenediamine breakdown", "trimethylenediamine catabolism", "trimethylenediamine degradation"], "types": ["T044"], "canonical_name": "trimethylenediamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of trimethylenediamine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010]"}
{"concept_id": "C3547661", "aliases": ["trimethylenediamine metabolism"], "types": ["T040"], "canonical_name": "trimethylenediamine metabolic process", "definition": "The chemical reactions and pathways involving trimethylenediamine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010]"}
{"concept_id": "C3547662", "aliases": ["sarcosine synthesis", "sarcosine biosynthesis", "sarcosine formation", "sarcosine anabolism"], "types": ["T044"], "canonical_name": "sarcosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sarcosine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292]"}
{"concept_id": "C3547663", "aliases": ["sarcosine catabolism", "sarcosine degradation", "sarcosine breakdown"], "types": ["T044"], "canonical_name": "sarcosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of sarcosine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292]"}
{"concept_id": "C3547664", "aliases": ["sarcosine metabolism"], "types": ["T044"], "canonical_name": "sarcosine metabolic process", "definition": "The chemical reactions and pathways involving sarcosine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292]"}
{"concept_id": "C3547665", "aliases": ["atropine biosynthesis", "atropine formation", "atropine anabolism", "atropine synthesis"], "types": ["T044"], "canonical_name": "atropine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of atropine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303]"}
{"concept_id": "C3547666", "aliases": ["atropine breakdown", "atropine catabolism", "atropine degradation"], "types": ["T044"], "canonical_name": "atropine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of atropine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303]"}
{"concept_id": "C3547667", "aliases": ["atropine metabolism"], "types": ["T044"], "canonical_name": "atropine metabolic process", "definition": "The chemical reactions and pathways involving atropine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303]"}
{"concept_id": "C3547668", "aliases": ["transforming growth factor beta receptor signaling pathway of regulation of multicellular organism growth", "TGF-beta receptor signaling pathway of regulation of body size", "TGFbeta receptor signalling pathway of regulation of body growth", "TGFbeta receptor signaling pathway of regulation of body growth", "TGFbeta receptor signalling pathway of regulation of body size", "TGFbeta receptor signaling pathway of regulation of multicellular organism growth", "TGFbeta receptor signaling pathway of regulation of body size", "transforming growth factor beta receptor signaling pathway of regulation of body size", "TGF-beta receptor signalling pathway of regulation of multicellular organism growth", "TGFbeta receptor signalling pathway of regulation of multicellular organism growth", "TGF-beta receptor signalling pathway of regulation of body growth", "transforming growth factor beta receptor signalling pathway of regulation of multicellular organism growth", "transforming growth factor beta receptor signalling pathway of regulation of body growth", "transforming growth factor beta receptor signalling pathway of regulation of body size", "transforming growth factor beta receptor signaling pathway of regulation of body growth", "TGF-beta receptor signaling pathway of regulation of multicellular organism growth", "TGF-beta receptor signaling pathway of regulation of body growth", "TGF-beta receptor signalling pathway of regulation of body size"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription, that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. [GOC:kmv, GOC:TermGenie, PMID:9847239]"}
{"concept_id": "C3547670", "aliases": [], "types": ["T044"], "canonical_name": "protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process", "definition": "Any protein polyubiquitination that is involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process. [GOC:al, GOC:TermGenie, PMID:21324894]"}
{"concept_id": "C3547672", "aliases": ["upregulation of peptide antigen transport", "up regulation of peptide antigen transport", "up-regulation of peptide antigen transport"], "types": ["T044"], "canonical_name": "positive regulation of peptide antigen transport", "definition": "Any process that activates or increases the frequency, rate or extent of peptide antigen transport. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3547673", "aliases": ["downregulation of peptide antigen transport", "down regulation of peptide antigen transport", "down-regulation of peptide antigen transport"], "types": ["T044"], "canonical_name": "negative regulation of peptide antigen transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport. [GOC:bf, GOC:TermGenie, PMID:16691491]"}
{"concept_id": "C3547674", "aliases": [], "types": ["T044"], "canonical_name": "regulation of peptide antigen transport", "definition": "Any process that modulates the frequency, rate or extent of peptide antigen transport. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3547675", "aliases": ["cyanidin 3-O-beta-D-glucoside metabolism", "cyanidin 3-O-beta-D-glucoside metabolic process"], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside metabolic process", "definition": "The chemical reactions and pathways involving cyanidin 3-O-beta-D-glucoside. [GOC:TermGenie, PMID:21899608]"}
{"concept_id": "C3547676", "aliases": ["upregulation of L-glutamine uptake", "up regulation of L-glutamine import", "up-regulation of L-glutamine uptake", "up-regulation of L-glutamine import", "activation of L-glutamine uptake", "positive regulation of L-glutamine import", "upregulation of L-glutamine import", "positive regulation of L-glutamine uptake", "up regulation of L-glutamine uptake"], "types": ["T044"], "canonical_name": "positive regulation of L-glutamine import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of L-glutamine import into cell. [GOC:TermGenie]"}
{"concept_id": "C3547677", "aliases": ["down regulation of L-glutamine import", "down regulation of L-glutamine uptake", "downregulation of L-glutamine uptake", "downregulation of L-glutamine import", "down-regulation of L-glutamine uptake"], "types": ["T044"], "canonical_name": "down-regulation of L-glutamine import"}
{"concept_id": "C3547678", "aliases": ["regulation of L-glutamine uptake", "regulation of L-glutamine import"], "types": ["T044"], "canonical_name": "regulation of L-glutamine import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of L-glutamine import into cell. [GOC:TermGenie]"}
{"concept_id": "C3547679", "aliases": ["up-regulation of response to reactive oxygen intermediate", "up regulation of response to ROI", "activation of response to reactive oxygen intermediate", "up regulation of response to reactive oxidative species", "upregulation of response to reactive oxygen intermediate", "up regulation of response to reactive oxygen intermediate", "upregulation of response to active oxygen species", "upregulation of response to ROI", "upregulation of response to reactive oxidative species", "activation of response to active oxygen species", "positive regulation of response to AOS", "positive regulation of response to reactive oxygen intermediate", "upregulation of response to reactive oxygen species", "activation of response to ROS", "up regulation of response to ROS", "up-regulation of response to ROI", "activation of response to ROI", "up-regulation of response to AOS", "up regulation of response to AOS", "up regulation of response to active oxygen species", "activation of response to reactive oxidative species", "upregulation of response to AOS", "positive regulation of response to reactive oxidative species", "up-regulation of response to ROS", "up-regulation of response to active oxygen species", "positive regulation of response to ROI", "upregulation of response to ROS", "activation of response to AOS", "up-regulation of response to reactive oxygen species", "positive regulation of response to ROS", "up regulation of response to reactive oxygen species", "up-regulation of response to reactive oxidative species", "positive regulation of response to active oxygen species"], "types": ["T044"], "canonical_name": "positive regulation of response to reactive oxygen species", "definition": "Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3547680", "aliases": ["negative regulation of response to ROI", "inhibition of response to active oxygen species", "down-regulation of response to ROS", "downregulation of response to ROI", "downregulation of response to AOS", "inhibition of response to reactive oxidative species", "negative regulation of response to reactive oxidative species", "inhibition of response to ROS", "down-regulation of response to active oxygen species", "down-regulation of response to AOS", "downregulation of response to reactive oxygen intermediate", "down regulation of response to ROI", "downregulation of response to ROS", "negative regulation of response to AOS", "downregulation of response to active oxygen species", "negative regulation of response to active oxygen species", "downregulation of response to reactive oxidative species", "inhibition of response to ROI", "negative regulation of response to ROS", "down-regulation of response to reactive oxygen species", "downregulation of response to reactive oxygen species", "inhibition of response to reactive oxygen intermediate", "down regulation of response to reactive oxygen species", "negative regulation of response to reactive oxygen intermediate", "down regulation of response to ROS", "down regulation of response to active oxygen species", "down regulation of response to AOS", "inhibition of response to AOS", "down regulation of response to reactive oxidative species", "down regulation of response to reactive oxygen intermediate", "down-regulation of response to reactive oxygen intermediate", "down-regulation of response to reactive oxidative species", "down-regulation of response to ROI"], "types": ["T038"], "canonical_name": "negative regulation of response to reactive oxygen species", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3547681", "aliases": ["regulation of response to reactive oxidative species", "regulation of response to reactive oxygen intermediate", "regulation of response to ROS", "regulation of response to AOS", "regulation of response to ROI", "regulation of response to active oxygen species"], "types": ["T039"], "canonical_name": "regulation of response to reactive oxygen species", "definition": "Any process that modulates the frequency, rate or extent of response to reactive oxygen species. [GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C3547682", "aliases": ["up-regulation of MOMP", "up regulation of MOMP", "positive regulation of mitochondrial outer membrane permeabilization", "positive regulation of MOMP", "up-regulation of mitochondrial outer membrane permeabilization", "upregulation of MOMP", "upregulation of mitochondrial outer membrane permeabilization", "up regulation of mitochondrial outer membrane permeabilization"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3547683", "aliases": ["down-regulation of MOMP", "down-regulation of mitochondrial outer membrane permeabilization", "downregulation of mitochondrial outer membrane permeabilization", "downregulation of MOMP", "negative regulation of MOMP", "down regulation of MOMP", "down regulation of mitochondrial outer membrane permeabilization"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial outer membrane permeabilization"}
{"concept_id": "C3547684", "aliases": ["regulation of MOMP"], "types": ["T043"], "canonical_name": "regulation of mitochondrial outer membrane permeabilization"}
{"concept_id": "C3547685", "aliases": ["dextrin breakdown", "dextrin catabolism", "dextrin degradation"], "types": ["T044"], "canonical_name": "dextrin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dextrin. [GOC:TermGenie]"}
{"concept_id": "C3547686", "aliases": ["ripoptosome assembly involved in necroptosis"], "types": ["T044"], "canonical_name": "ripoptosome assembly involved in necroptotic process", "definition": "The aggregation, arrangement and bonding together of ripoptosome components leading to a necroptotic process. [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400]"}
{"concept_id": "C3547687", "aliases": [], "types": ["T044"], "canonical_name": "ripoptosome assembly involved in extrinsic apoptotic signaling pathway", "definition": "The aggregation, arrangement and bonding together of ripoptosome components leading to apoptosis via the extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400]"}
{"concept_id": "C3547688", "aliases": ["4-hydroxyphenylacetate biosynthesis", "4-hydroxyphenylacetate anabolism", "4-hydroxyphenylacetate synthesis", "4-hydroxyphenylacetate formation"], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 4-hydroxyphenylacetate. [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208]"}
{"concept_id": "C3547689", "aliases": ["4-hydroxyphenylacetate degradation", "4-hydroxyphenylacetate catabolism", "4-hydroxyphenylacetate breakdown"], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyphenylacetate. [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208]"}
{"concept_id": "C3547690", "aliases": ["4-hydroxyphenylacetate metabolism"], "types": ["T044"], "canonical_name": "4-hydroxyphenylacetate metabolic process", "definition": "The chemical reactions and pathways involving 4-hydroxyphenylacetate. [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208]"}
{"concept_id": "C3547691", "aliases": ["upregulation of calcium ion transmembrane transporter activity", "up regulation of calcium ion transmembrane transporter activity", "up-regulation of calcium ion transmembrane transporter activity"], "types": ["T038"], "canonical_name": "positive regulation of calcium ion transmembrane transporter activity", "definition": "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547692", "aliases": ["down regulation of calcium ion transmembrane transporter activity", "down-regulation of calcium ion transmembrane transporter activity", "downregulation of calcium ion transmembrane transporter activity"], "types": ["T044"], "canonical_name": "negative regulation of calcium ion transmembrane transporter activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547693", "aliases": [], "types": ["T038"], "canonical_name": "regulation of calcium ion transmembrane transporter activity", "definition": "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547694", "aliases": ["up-regulation of potassium ion transmembrane transporter activity", "upregulation of potassium transporter activity", "up regulation of potassium ion transmembrane transporter activity", "up regulation of potassium transporter activity", "activation of potassium transporter activity", "upregulation of potassium ion transmembrane transporter activity", "up-regulation of potassium transporter activity", "positive regulation of potassium transporter activity"], "types": ["T038"], "canonical_name": "positive regulation of potassium ion transmembrane transporter activity", "definition": "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547695", "aliases": ["downregulation of potassium transporter activity", "inhibition of potassium transporter activity", "downregulation of potassium ion transmembrane transporter activity", "down regulation of potassium ion transmembrane transporter activity", "down-regulation of potassium transporter activity", "down regulation of potassium transporter activity", "down-regulation of potassium ion transmembrane transporter activity", "negative regulation of potassium transporter activity"], "types": ["T044"], "canonical_name": "negative regulation of potassium ion transmembrane transporter activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547696", "aliases": ["regulation of potassium transporter activity"], "types": ["T038"], "canonical_name": "regulation of potassium ion transmembrane transporter activity", "definition": "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547697", "aliases": ["3alpha(S)-strictosidine synthesis", "3alpha(S)-strictosidine formation", "3alpha(S)-strictosidine biosynthesis", "3alpha(S)-strictosidine anabolism"], "types": ["T044"], "canonical_name": "3alpha(S)-strictosidine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 3alpha(S)-strictosidine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311]"}
{"concept_id": "C3547698", "aliases": ["3alpha(S)-strictosidine catabolism", "3alpha(S)-strictosidine breakdown", "3alpha(S)-strictosidine degradation"], "types": ["T044"], "canonical_name": "3alpha(S)-strictosidine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3alpha(S)-strictosidine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311]"}
{"concept_id": "C3547699", "aliases": ["3alpha(S)-strictosidine metabolism"], "types": ["T044"], "canonical_name": "3alpha(S)-strictosidine metabolic process", "definition": "The chemical reactions and pathways involving 3alpha(S)-strictosidine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311]"}
{"concept_id": "C3547700", "aliases": ["(S)-reticuline anabolism", "(S)-reticuline synthesis", "(S)-reticuline formation", "(S)-reticuline biosynthesis"], "types": ["T044"], "canonical_name": "(S)-reticuline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (S)-reticuline. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306]"}
{"concept_id": "C3547701", "aliases": ["(S)-reticuline degradation", "(S)-reticuline breakdown", "(S)-reticuline catabolism"], "types": ["T044"], "canonical_name": "(S)-reticuline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (S)-reticuline. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306]"}
{"concept_id": "C3547702", "aliases": ["(S)-reticuline metabolism"], "types": ["T044"], "canonical_name": "(S)-reticuline metabolic process", "definition": "The chemical reactions and pathways involving (S)-reticuline. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306]"}
{"concept_id": "C3547703", "aliases": ["(S)-scoulerine synthesis", "(S)-scoulerine biosynthesis", "(S)-scoulerine anabolism", "(S)-scoulerine formation"], "types": ["T044"], "canonical_name": "(S)-scoulerine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (S)-scoulerine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319]"}
{"concept_id": "C3547704", "aliases": ["(S)-scoulerine breakdown", "(S)-scoulerine catabolism", "(S)-scoulerine degradation"], "types": ["T044"], "canonical_name": "(S)-scoulerine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (S)-scoulerine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319]"}
{"concept_id": "C3547705", "aliases": ["(S)-scoulerine metabolism"], "types": ["T044"], "canonical_name": "(S)-scoulerine metabolic process", "definition": "The chemical reactions and pathways involving (S)-scoulerine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319]"}
{"concept_id": "C3547706", "aliases": ["ubiquinone-6 anabolism", "ubiquinone-6 synthesis", "ubiquinone-6 biosynthesis", "ubiquinone-6 formation"], "types": ["T044"], "canonical_name": "ubiquinone-6 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ubiquinone-6. [GOC:TermGenie]"}
{"concept_id": "C3547707", "aliases": ["ubiquinone-6 degradation", "ubiquinone-6 catabolism", "ubiquinone-6 breakdown"], "types": ["T044"], "canonical_name": "ubiquinone-6 catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ubiquinone-6. [GOC:TermGenie]"}
{"concept_id": "C3547708", "aliases": ["down regulation of fermentation", "downregulation of fermentation", "down-regulation of fermentation"], "types": ["T044"], "canonical_name": "negative regulation of fermentation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fermentation. [GOC:TermGenie]"}
{"concept_id": "C3547709", "aliases": ["upregulation of response to salt stress", "up-regulation of response to ionic osmotic stress", "up regulation of response to ionic osmotic stress", "activation of salinity response", "up regulation of response to salt stress", "positive regulation of salinity response", "up-regulation of response to salt stress", "upregulation of response to ionic osmotic stress", "upregulation of salinity response", "positive regulation of response to ionic osmotic stress", "up regulation of salinity response", "activation of response to ionic osmotic stress", "up-regulation of salinity response"], "types": ["T039"], "canonical_name": "positive regulation of response to salt stress", "definition": "Any process that activates or increases the frequency, rate or extent of response to salt stress. [GOC:TermGenie, PMID:22627139]"}
{"concept_id": "C3547710", "aliases": ["down-regulation of salinity response", "down regulation of salinity response", "down-regulation of response to ionic osmotic stress", "negative regulation of salinity response", "inhibition of response to ionic osmotic stress", "downregulation of salinity response", "down-regulation of response to salt stress", "downregulation of response to ionic osmotic stress", "inhibition of salinity response", "down regulation of response to ionic osmotic stress", "down regulation of response to salt stress", "negative regulation of response to ionic osmotic stress", "downregulation of response to salt stress"], "types": ["T038"], "canonical_name": "negative regulation of response to salt stress", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to salt stress. [GOC:TermGenie, PMID:22627139]"}
{"concept_id": "C3547711", "aliases": ["regulation of salinity response", "regulation of response to ionic osmotic stress"], "types": ["T043"], "canonical_name": "regulation of response to salt stress", "definition": "Any process that modulates the frequency, rate or extent of response to salt stress. [GOC:TermGenie, PMID:22627139]"}
{"concept_id": "C3547712", "aliases": ["nitrobenzene anabolism", "nitrobenzene synthesis", "nitrobenzene biosynthesis", "nitrobenzene formation"], "types": ["T044"], "canonical_name": "nitrobenzene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nitrobenzene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923]"}
{"concept_id": "C3547713", "aliases": ["nitrobenzene catabolism", "nitrobenzene breakdown", "nitrobenzene degradation"], "types": ["T044"], "canonical_name": "nitrobenzene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of nitrobenzene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923]"}
{"concept_id": "C3547714", "aliases": ["benzene anabolism", "benzene synthesis", "benzene biosynthesis", "benzene formation"], "types": ["T044"], "canonical_name": "benzene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of benzene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272]"}
{"concept_id": "C3547715", "aliases": ["benzene catabolism", "benzene breakdown", "benzene degradation"], "types": ["T044"], "canonical_name": "benzene catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of benzene. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272]"}
{"concept_id": "C3547716", "aliases": [], "types": ["T044"], "canonical_name": "ubiquinone-6 binding", "definition": "Binding to ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2. [GOC:al, GOC:TermGenie]"}
{"concept_id": "C3547717", "aliases": ["(-)-secologanin biosynthesis", "(-)-secologanin formation", "(-)-secologanin anabolism", "(-)-secologanin synthesis"], "types": ["T044"], "canonical_name": "(-)-secologanin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (-)-secologanin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328]"}
{"concept_id": "C3547718", "aliases": ["(-)-secologanin breakdown", "(-)-secologanin catabolism", "(-)-secologanin degradation"], "types": ["T044"], "canonical_name": "(-)-secologanin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (-)-secologanin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328]"}
{"concept_id": "C3547719", "aliases": ["(-)-secologanin metabolism"], "types": ["T044"], "canonical_name": "(-)-secologanin metabolic process", "definition": "The chemical reactions and pathways involving (-)-secologanin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328]"}
{"concept_id": "C3547720", "aliases": ["scopolamine anabolism", "scopolamine synthesis", "scopolamine biosynthesis", "scopolamine formation"], "types": ["T044"], "canonical_name": "scopolamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of scopolamine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725]"}
{"concept_id": "C3547721", "aliases": ["scopolamine degradation", "scopolamine breakdown", "scopolamine catabolism"], "types": ["T044"], "canonical_name": "scopolamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of scopolamine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725]"}
{"concept_id": "C3547722", "aliases": ["scopolamine metabolism"], "types": ["T044"], "canonical_name": "scopolamine metabolic process", "definition": "The chemical reactions and pathways involving scopolamine. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725]"}
{"concept_id": "C3547723", "aliases": ["ajmaline biosynthesis", "ajmaline formation", "ajmaline anabolism", "ajmaline synthesis"], "types": ["T044"], "canonical_name": "ajmaline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ajmaline. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310]"}
{"concept_id": "C3547724", "aliases": ["ajmaline breakdown", "ajmaline catabolism", "ajmaline degradation"], "types": ["T044"], "canonical_name": "ajmaline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ajmaline. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310]"}
{"concept_id": "C3547725", "aliases": ["ajmaline metabolism"], "types": ["T044"], "canonical_name": "ajmaline metabolic process", "definition": "The chemical reactions and pathways involving ajmaline. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310]"}
{"concept_id": "C3547726", "aliases": ["vindoline formation", "vindoline synthesis", "vindoline biosynthesis", "vindoline anabolism"], "types": ["T044"], "canonical_name": "vindoline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of vindoline. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365]"}
{"concept_id": "C3547727", "aliases": ["vindoline catabolism", "vindoline breakdown", "vindoline degradation"], "types": ["T044"], "canonical_name": "vindoline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of vindoline. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365]"}
{"concept_id": "C3547728", "aliases": ["vindoline metabolism"], "types": ["T044"], "canonical_name": "vindoline metabolic process", "definition": "The chemical reactions and pathways involving vindoline. [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365]"}
{"concept_id": "C3547729", "aliases": ["up regulation of phenazine biosynthetic process", "up-regulation of phenazine biosynthetic process", "upregulation of phenazine biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of phenazine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of phenazine biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547730", "aliases": ["down regulation of phenazine biosynthetic process", "down-regulation of phenazine biosynthetic process", "downregulation of phenazine biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of phenazine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phenazine biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547731", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phenazine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of phenazine biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547732", "aliases": ["up-regulation of tatiopterin metabolic process", "positive regulation of tatiopterin metabolism", "activation of tatiopterin metabolism", "up regulation of tatiopterin metabolism", "upregulation of tatiopterin metabolism", "up regulation of tatiopterin metabolic process", "up-regulation of tatiopterin metabolism", "upregulation of tatiopterin metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of tatiopterin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of tatiopterin metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547733", "aliases": ["negative regulation of tatiopterin metabolism", "inhibition of tatiopterin metabolism", "downregulation of tatiopterin metabolic process", "down regulation of tatiopterin metabolic process", "down-regulation of tatiopterin metabolism", "down-regulation of tatiopterin metabolic process", "down regulation of tatiopterin metabolism", "downregulation of tatiopterin metabolism"], "types": ["T044"], "canonical_name": "negative regulation of tatiopterin metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547734", "aliases": ["regulation of tatiopterin metabolism"], "types": ["T044"], "canonical_name": "regulation of tatiopterin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of tatiopterin metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547735", "aliases": ["down-regulation of tatiopterin formation", "downregulation of tatiopterin biosynthesis", "negative regulation of tatiopterin synthesis", "inhibition of tatiopterin biosynthesis", "down-regulation of tatiopterin biosynthesis", "downregulation of tatiopterin synthesis", "down regulation of tatiopterin anabolism", "downregulation of tatiopterin formation", "inhibition of tatiopterin synthesis", "down-regulation of tatiopterin anabolism", "downregulation of tatiopterin anabolism", "down-regulation of tatiopterin synthesis", "down regulation of tatiopterin synthesis", "negative regulation of tatiopterin anabolism", "inhibition of tatiopterin anabolism", "negative regulation of tatiopterin formation", "down regulation of tatiopterin biosynthesis", "downregulation of tatiopterin biosynthetic process", "inhibition of tatiopterin formation", "down regulation of tatiopterin biosynthetic process", "down-regulation of tatiopterin biosynthetic process", "negative regulation of tatiopterin biosynthesis", "down regulation of tatiopterin formation"], "types": ["T044"], "canonical_name": "negative regulation of tatiopterin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547736", "aliases": ["regulation of tatiopterin formation", "regulation of tatiopterin synthesis", "regulation of tatiopterin anabolism", "regulation of tatiopterin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of tatiopterin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of tatiopterin biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547737", "aliases": ["downregulation of sarcinapterin anabolism", "negative regulation of sarcinapterin anabolism", "inhibition of sarcinapterin formation", "down-regulation of sarcinapterin formation", "negative regulation of sarcinapterin synthesis", "downregulation of sarcinapterin formation", "down-regulation of sarcinapterin biosynthesis", "inhibition of sarcinapterin synthesis", "down regulation of sarcinapterin synthesis", "down-regulation of sarcinapterin synthesis", "downregulation of sarcinapterin synthesis", "down-regulation of sarcinapterin biosynthetic process", "negative regulation of sarcinapterin formation", "downregulation of sarcinapterin biosynthetic process", "negative regulation of sarcinapterin biosynthesis", "down regulation of sarcinapterin biosynthetic process", "downregulation of sarcinapterin biosynthesis", "inhibition of sarcinapterin biosynthesis", "inhibition of sarcinapterin anabolism", "down regulation of sarcinapterin formation", "down-regulation of sarcinapterin anabolism", "down regulation of sarcinapterin biosynthesis", "down regulation of sarcinapterin anabolism"], "types": ["T044"], "canonical_name": "negative regulation of sarcinapterin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547738", "aliases": ["regulation of sarcinapterin biosynthesis", "regulation of sarcinapterin anabolism", "regulation of sarcinapterin formation", "regulation of sarcinapterin synthesis"], "types": ["T044"], "canonical_name": "regulation of sarcinapterin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of sarcinapterin biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547739", "aliases": ["upregulation of sarcinapterin metabolism", "up regulation of sarcinapterin metabolic process", "up-regulation of sarcinapterin metabolic process", "activation of sarcinapterin metabolism", "up-regulation of sarcinapterin metabolism", "up regulation of sarcinapterin metabolism", "upregulation of sarcinapterin metabolic process", "positive regulation of sarcinapterin metabolism"], "types": ["T044"], "canonical_name": "positive regulation of sarcinapterin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of sarcinapterin metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547740", "aliases": ["inhibition of sarcinapterin metabolism", "downregulation of sarcinapterin metabolic process", "downregulation of sarcinapterin metabolism", "negative regulation of sarcinapterin metabolism", "down-regulation of sarcinapterin metabolic process", "down regulation of sarcinapterin metabolic process", "down-regulation of sarcinapterin metabolism", "down regulation of sarcinapterin metabolism"], "types": ["T044"], "canonical_name": "negative regulation of sarcinapterin metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547741", "aliases": ["regulation of sarcinapterin metabolism"], "types": ["T044"], "canonical_name": "regulation of sarcinapterin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of sarcinapterin metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547742", "aliases": ["up regulation of methanophenazine metabolism", "upregulation of methanophenazine metabolism", "positive regulation of methanophenazine metabolism", "up regulation of methanophenazine metabolic process", "up-regulation of methanophenazine metabolism", "activation of methanophenazine metabolism", "upregulation of methanophenazine metabolic process", "up-regulation of methanophenazine metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of methanophenazine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of methanophenazine metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547743", "aliases": ["down regulation of methanophenazine metabolism", "down-regulation of methanophenazine metabolism", "down-regulation of methanophenazine metabolic process", "inhibition of methanophenazine metabolism", "negative regulation of methanophenazine metabolism", "downregulation of methanophenazine metabolic process", "down regulation of methanophenazine metabolic process", "downregulation of methanophenazine metabolism"], "types": ["T044"], "canonical_name": "negative regulation of methanophenazine metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547744", "aliases": ["regulation of methanophenazine metabolism"], "types": ["T044"], "canonical_name": "regulation of methanophenazine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of methanophenazine metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547745", "aliases": ["down regulation of methanophenazine synthesis", "downregulation of methanophenazine anabolism", "down regulation of methanophenazine biosynthetic process", "down-regulation of methanophenazine formation", "downregulation of methanophenazine biosynthetic process", "downregulation of methanophenazine synthesis", "inhibition of methanophenazine formation", "downregulation of methanophenazine formation", "downregulation of methanophenazine biosynthesis", "down-regulation of methanophenazine biosynthetic process", "down regulation of methanophenazine biosynthesis", "inhibition of methanophenazine synthesis", "inhibition of methanophenazine biosynthesis", "down regulation of methanophenazine formation", "inhibition of methanophenazine anabolism", "down-regulation of methanophenazine biosynthesis", "negative regulation of methanophenazine formation", "negative regulation of methanophenazine synthesis", "negative regulation of methanophenazine biosynthesis", "down-regulation of methanophenazine synthesis", "down-regulation of methanophenazine anabolism", "down regulation of methanophenazine anabolism", "negative regulation of methanophenazine anabolism"], "types": ["T044"], "canonical_name": "negative regulation of methanophenazine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547746", "aliases": ["regulation of methanophenazine anabolism", "regulation of methanophenazine synthesis", "regulation of methanophenazine biosynthesis", "regulation of methanophenazine formation"], "types": ["T044"], "canonical_name": "regulation of methanophenazine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of methanophenazine biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547747", "aliases": ["up regulation of 17-methylnonadec-1-ene metabolic process", "positive regulation of 17-methylnonadec-1-ene metabolism", "up-regulation of 17-methylnonadec-1-ene metabolism", "activation of 17-methylnonadec-1-ene metabolism", "upregulation of 17-methylnonadec-1-ene metabolism", "upregulation of 17-methylnonadec-1-ene metabolic process", "up-regulation of 17-methylnonadec-1-ene metabolic process", "up regulation of 17-methylnonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "positive regulation of 17-methylnonadec-1-ene metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547748", "aliases": ["down regulation of 17-methylnonadec-1-ene metabolic process", "downregulation of 17-methylnonadec-1-ene metabolic process", "down-regulation of 17-methylnonadec-1-ene metabolic process", "negative regulation of 17-methylnonadec-1-ene metabolism", "inhibition of 17-methylnonadec-1-ene metabolism", "downregulation of 17-methylnonadec-1-ene metabolism", "down regulation of 17-methylnonadec-1-ene metabolism", "down-regulation of 17-methylnonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "negative regulation of 17-methylnonadec-1-ene metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547749", "aliases": ["regulation of 17-methylnonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "regulation of 17-methylnonadec-1-ene metabolic process", "definition": "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547750", "aliases": ["inhibition of 17-methylnonadec-1-ene anabolism", "down-regulation of 17-methylnonadec-1-ene biosynthesis", "negative regulation of 17-methylnonadec-1-ene synthesis", "down-regulation of 17-methylnonadec-1-ene biosynthetic process", "down-regulation of 17-methylnonadec-1-ene anabolism", "down-regulation of 17-methylnonadec-1-ene synthesis", "downregulation of 17-methylnonadec-1-ene biosynthetic process", "inhibition of 17-methylnonadec-1-ene synthesis", "negative regulation of 17-methylnonadec-1-ene formation", "down-regulation of 17-methylnonadec-1-ene formation", "downregulation of 17-methylnonadec-1-ene anabolism", "downregulation of 17-methylnonadec-1-ene formation", "down regulation of 17-methylnonadec-1-ene formation", "down regulation of 17-methylnonadec-1-ene synthesis", "negative regulation of 17-methylnonadec-1-ene anabolism", "downregulation of 17-methylnonadec-1-ene synthesis", "downregulation of 17-methylnonadec-1-ene biosynthesis", "down regulation of 17-methylnonadec-1-ene anabolism", "down regulation of 17-methylnonadec-1-ene biosynthesis", "inhibition of 17-methylnonadec-1-ene formation", "down regulation of 17-methylnonadec-1-ene biosynthetic process", "negative regulation of 17-methylnonadec-1-ene biosynthesis", "inhibition of 17-methylnonadec-1-ene biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of 17-methylnonadec-1-ene biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547751", "aliases": ["regulation of 17-methylnonadec-1-ene biosynthesis", "regulation of 17-methylnonadec-1-ene synthesis", "regulation of 17-methylnonadec-1-ene formation", "regulation of 17-methylnonadec-1-ene anabolism"], "types": ["T044"], "canonical_name": "regulation of 17-methylnonadec-1-ene biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547752", "aliases": ["up-regulation of 18-methylnonadec-1-ene metabolic process", "activation of 18-methylnonadec-1-ene metabolism", "upregulation of 18-methylnonadec-1-ene metabolism", "up regulation of 18-methylnonadec-1-ene metabolic process", "upregulation of 18-methylnonadec-1-ene metabolic process", "up regulation of 18-methylnonadec-1-ene metabolism", "positive regulation of 18-methylnonadec-1-ene metabolism", "up-regulation of 18-methylnonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "positive regulation of 18-methylnonadec-1-ene metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547753", "aliases": ["down-regulation of 18-methylnonadec-1-ene metabolism", "downregulation of 18-methylnonadec-1-ene metabolism", "downregulation of 18-methylnonadec-1-ene metabolic process", "down regulation of 18-methylnonadec-1-ene metabolism", "negative regulation of 18-methylnonadec-1-ene metabolism", "inhibition of 18-methylnonadec-1-ene metabolism", "down regulation of 18-methylnonadec-1-ene metabolic process", "down-regulation of 18-methylnonadec-1-ene metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of 18-methylnonadec-1-ene metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547754", "aliases": ["regulation of 18-methylnonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "regulation of 18-methylnonadec-1-ene metabolic process", "definition": "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547755", "aliases": ["inhibition of 18-methylnonadec-1-ene anabolism", "down-regulation of 18-methylnonadec-1-ene anabolism", "down regulation of 18-methylnonadec-1-ene formation", "downregulation of 18-methylnonadec-1-ene biosynthesis", "downregulation of 18-methylnonadec-1-ene biosynthetic process", "downregulation of 18-methylnonadec-1-ene anabolism", "down-regulation of 18-methylnonadec-1-ene synthesis", "downregulation of 18-methylnonadec-1-ene synthesis", "negative regulation of 18-methylnonadec-1-ene biosynthesis", "negative regulation of 18-methylnonadec-1-ene formation", "inhibition of 18-methylnonadec-1-ene synthesis", "down regulation of 18-methylnonadec-1-ene biosynthesis", "down regulation of 18-methylnonadec-1-ene synthesis", "negative regulation of 18-methylnonadec-1-ene anabolism", "down-regulation of 18-methylnonadec-1-ene biosynthetic process", "down-regulation of 18-methylnonadec-1-ene biosynthesis", "downregulation of 18-methylnonadec-1-ene formation", "down regulation of 18-methylnonadec-1-ene biosynthetic process", "down regulation of 18-methylnonadec-1-ene anabolism", "inhibition of 18-methylnonadec-1-ene formation", "inhibition of 18-methylnonadec-1-ene biosynthesis", "negative regulation of 18-methylnonadec-1-ene synthesis", "down-regulation of 18-methylnonadec-1-ene formation"], "types": ["T044"], "canonical_name": "negative regulation of 18-methylnonadec-1-ene biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547756", "aliases": ["regulation of 18-methylnonadec-1-ene biosynthesis", "regulation of 18-methylnonadec-1-ene synthesis", "regulation of 18-methylnonadec-1-ene anabolism", "regulation of 18-methylnonadec-1-ene formation"], "types": ["T044"], "canonical_name": "regulation of 18-methylnonadec-1-ene biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547757", "aliases": ["downregulation of 2-methyl-1,3-butadiene biosynthetic process", "downregulation of 2-methyl-1,3-butadiene biosynthesis", "down regulation of 2-methyl-1,3-butadiene biosynthesis", "downregulation of isoprene biosynthetic process", "down regulation of isoprene biosynthetic process", "down-regulation of hemiterpene biosynthetic process", "down regulation of hemiterpene biosynthesis", "downregulation of hemiterpene biosynthesis", "down-regulation of 2-methyl-1,3-butadiene biosynthetic process", "negative regulation of hemiterpene biosynthesis", "downregulation of hemiterpene biosynthetic process", "down regulation of hemiterpene biosynthetic process", "down regulation of 2-methyl-1,3-butadiene biosynthetic process", "negative regulation of 2-methyl-1,3-butadiene biosynthesis", "negative regulation of hemiterpene biosynthetic process", "down-regulation of 2-methyl-1,3-butadiene biosynthesis", "negative regulation of 2-methyl-1,3-butadiene biosynthetic process", "down-regulation of hemiterpene biosynthesis", "down-regulation of isoprene biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of isoprene biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547758", "aliases": ["regulation of hemiterpene biosynthesis", "regulation of 2-methyl-1,3-butadiene biosynthetic process", "regulation of 2-methyl-1,3-butadiene biosynthesis", "regulation of hemiterpene biosynthetic process"], "types": ["T044"], "canonical_name": "regulation of isoprene biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of isoprene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547759", "aliases": ["upregulation of hemiterpene metabolic process", "upregulation of isoprene metabolic process", "positive regulation of 2-methyl-1,3-butadiene metabolic process", "up regulation of isoprene metabolic process", "positive regulation of isoprene metabolism", "positive regulation of hemiterpene metabolism", "upregulation of isoprene metabolism", "up-regulation of 2-methyl-1,3-butadiene metabolic process", "upregulation of hemiterpene metabolism", "up regulation of hemiterpene metabolic process", "up-regulation of isoprene metabolic process", "up regulation of 2-methyl-1,3-butadiene metabolism", "positive regulation of 2-methyl-1,3-butadiene metabolism", "up regulation of isoprene metabolism", "up-regulation of hemiterpene metabolic process", "upregulation of 2-methyl-1,3-butadiene metabolic process", "upregulation of 2-methyl-1,3-butadiene metabolism", "up regulation of 2-methyl-1,3-butadiene metabolic process", "up regulation of hemiterpene metabolism", "up-regulation of hemiterpene metabolism", "up-regulation of isoprene metabolism", "positive regulation of hemiterpene metabolic process", "up-regulation of 2-methyl-1,3-butadiene metabolism"], "types": ["T044"], "canonical_name": "positive regulation of isoprene metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of isoprene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547760", "aliases": ["down regulation of hemiterpene metabolism", "down-regulation of isoprene metabolism", "down regulation of 2-methyl-1,3-butadiene metabolism", "negative regulation of 2-methyl-1,3-butadiene metabolism", "downregulation of isoprene metabolism", "down-regulation of hemiterpene metabolic process", "negative regulation of 2-methyl-1,3-butadiene metabolic process", "downregulation of isoprene metabolic process", "down regulation of isoprene metabolism", "downregulation of 2-methyl-1,3-butadiene metabolism", "downregulation of hemiterpene metabolic process", "down-regulation of 2-methyl-1,3-butadiene metabolic process", "downregulation of 2-methyl-1,3-butadiene metabolic process", "down-regulation of hemiterpene metabolism", "negative regulation of isoprene metabolism", "down-regulation of isoprene metabolic process", "down regulation of isoprene metabolic process", "downregulation of hemiterpene metabolism", "negative regulation of hemiterpene metabolic process", "negative regulation of hemiterpene metabolism", "down regulation of 2-methyl-1,3-butadiene metabolic process", "down regulation of hemiterpene metabolic process", "down-regulation of 2-methyl-1,3-butadiene metabolism"], "types": ["T044"], "canonical_name": "negative regulation of isoprene metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547761", "aliases": ["regulation of hemiterpene metabolic process", "regulation of 2-methyl-1,3-butadiene metabolism", "regulation of isoprene metabolism", "regulation of 2-methyl-1,3-butadiene metabolic process", "regulation of hemiterpene metabolism"], "types": ["T044"], "canonical_name": "regulation of isoprene metabolic process", "definition": "Any process that modulates the frequency, rate or extent of isoprene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547762", "aliases": ["up-regulation of (Z)-nonadeca-1,14-diene biosynthesis", "up-regulation of (Z)-nonadeca-1,14-diene anabolism", "upregulation of (Z)-nonadeca-1,14-diene synthesis", "positive regulation of (Z)-nonadeca-1,14-diene synthesis", "up regulation of (Z)-nonadeca-1,14-diene formation", "up-regulation of (Z)-nonadeca-1,14-diene biosynthetic process", "upregulation of (Z)-nonadeca-1,14-diene formation", "up regulation of (Z)-nonadeca-1,14-diene anabolism", "upregulation of (Z)-nonadeca-1,14-diene anabolism", "up regulation of (Z)-nonadeca-1,14-diene synthesis", "upregulation of (Z)-nonadeca-1,14-diene biosynthesis", "up-regulation of (Z)-nonadeca-1,14-diene synthesis", "positive regulation of (Z)-nonadeca-1,14-diene formation", "up regulation of (Z)-nonadeca-1,14-diene biosynthesis", "upregulation of (Z)-nonadeca-1,14-diene biosynthetic process", "up regulation of (Z)-nonadeca-1,14-diene biosynthetic process", "up-regulation of (Z)-nonadeca-1,14-diene formation", "positive regulation of (Z)-nonadeca-1,14-diene biosynthesis", "positive regulation of (Z)-nonadeca-1,14-diene anabolism"], "types": ["T044"], "canonical_name": "positive regulation of (Z)-nonadeca-1,14-diene biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547763", "aliases": ["downregulation of (Z)-nonadeca-1,14-diene formation", "negative regulation of (Z)-nonadeca-1,14-diene synthesis", "down-regulation of (Z)-nonadeca-1,14-diene formation", "down regulation of (Z)-nonadeca-1,14-diene formation", "negative regulation of (Z)-nonadeca-1,14-diene formation", "down-regulation of (Z)-nonadeca-1,14-diene synthesis", "downregulation of (Z)-nonadeca-1,14-diene anabolism", "downregulation of (Z)-nonadeca-1,14-diene biosynthesis", "down-regulation of (Z)-nonadeca-1,14-diene biosynthesis", "down regulation of (Z)-nonadeca-1,14-diene biosynthetic process", "down regulation of (Z)-nonadeca-1,14-diene anabolism", "downregulation of (Z)-nonadeca-1,14-diene biosynthetic process", "down regulation of (Z)-nonadeca-1,14-diene synthesis", "down-regulation of (Z)-nonadeca-1,14-diene anabolism", "downregulation of (Z)-nonadeca-1,14-diene synthesis", "down regulation of (Z)-nonadeca-1,14-diene biosynthesis", "negative regulation of (Z)-nonadeca-1,14-diene biosynthesis", "negative regulation of (Z)-nonadeca-1,14-diene anabolism", "down-regulation of (Z)-nonadeca-1,14-diene biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of (Z)-nonadeca-1,14-diene biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547764", "aliases": ["regulation of (Z)-nonadeca-1,14-diene anabolism", "regulation of (Z)-nonadeca-1,14-diene biosynthesis", "regulation of (Z)-nonadeca-1,14-diene formation", "regulation of (Z)-nonadeca-1,14-diene synthesis"], "types": ["T044"], "canonical_name": "regulation of (Z)-nonadeca-1,14-diene biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547765", "aliases": ["up-regulation of (Z)-nonadeca-1,14-diene metabolic process", "up-regulation of (Z)-nonadeca-1,14-diene metabolism", "upregulation of (Z)-nonadeca-1,14-diene metabolic process", "upregulation of (Z)-nonadeca-1,14-diene metabolism", "up regulation of (Z)-nonadeca-1,14-diene metabolism", "activation of (Z)-nonadeca-1,14-diene metabolism", "positive regulation of (Z)-nonadeca-1,14-diene metabolism", "up regulation of (Z)-nonadeca-1,14-diene metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of (Z)-nonadeca-1,14-diene metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547766", "aliases": ["down regulation of (Z)-nonadeca-1,14-diene metabolism", "downregulation of (Z)-nonadeca-1,14-diene metabolism", "down regulation of (Z)-nonadeca-1,14-diene metabolic process", "inhibition of (Z)-nonadeca-1,14-diene metabolism", "down-regulation of (Z)-nonadeca-1,14-diene metabolism", "downregulation of (Z)-nonadeca-1,14-diene metabolic process", "negative regulation of (Z)-nonadeca-1,14-diene metabolism", "down-regulation of (Z)-nonadeca-1,14-diene metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of (Z)-nonadeca-1,14-diene metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547767", "aliases": ["regulation of (Z)-nonadeca-1,14-diene metabolism"], "types": ["T044"], "canonical_name": "regulation of (Z)-nonadeca-1,14-diene metabolic process", "definition": "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547768", "aliases": ["down regulation of nonadec-1-ene synthesis", "negative regulation of nonadec-1-ene anabolism", "negative regulation of nonadec-1-ene synthesis", "downregulation of nonadec-1-ene biosynthetic process", "down regulation of nonadec-1-ene biosynthetic process", "down regulation of nonadec-1-ene formation", "inhibition of nonadec-1-ene anabolism", "downregulation of nonadec-1-ene formation", "downregulation of nonadec-1-ene biosynthesis", "down-regulation of nonadec-1-ene biosynthesis", "negative regulation of nonadec-1-ene biosynthesis", "inhibition of nonadec-1-ene biosynthesis", "down regulation of nonadec-1-ene anabolism", "downregulation of nonadec-1-ene anabolism", "down-regulation of nonadec-1-ene anabolism", "negative regulation of nonadec-1-ene formation", "inhibition of nonadec-1-ene formation", "down-regulation of nonadec-1-ene synthesis", "downregulation of nonadec-1-ene synthesis", "down-regulation of nonadec-1-ene formation", "down regulation of nonadec-1-ene biosynthesis", "down-regulation of nonadec-1-ene biosynthetic process", "inhibition of nonadec-1-ene synthesis"], "types": ["T044"], "canonical_name": "negative regulation of nonadec-1-ene biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547769", "aliases": ["regulation of nonadec-1-ene synthesis", "regulation of nonadec-1-ene biosynthesis", "regulation of nonadec-1-ene anabolism", "regulation of nonadec-1-ene formation"], "types": ["T044"], "canonical_name": "regulation of nonadec-1-ene biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of nonadec-1-ene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547770", "aliases": ["up-regulation of nonadec-1-ene metabolism", "upregulation of nonadec-1-ene metabolic process", "up regulation of nonadec-1-ene metabolic process", "positive regulation of nonadec-1-ene metabolism", "activation of nonadec-1-ene metabolism", "up regulation of nonadec-1-ene metabolism", "up-regulation of nonadec-1-ene metabolic process", "upregulation of nonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "positive regulation of nonadec-1-ene metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547771", "aliases": ["down-regulation of nonadec-1-ene metabolic process", "downregulation of nonadec-1-ene metabolic process", "down regulation of nonadec-1-ene metabolic process", "down-regulation of nonadec-1-ene metabolism", "inhibition of nonadec-1-ene metabolism", "negative regulation of nonadec-1-ene metabolism", "downregulation of nonadec-1-ene metabolism", "down regulation of nonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "negative regulation of nonadec-1-ene metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547772", "aliases": ["regulation of nonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "regulation of nonadec-1-ene metabolic process", "definition": "Any process that modulates the frequency, rate or extent of nonadec-1-ene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547773", "aliases": ["up-regulation of L-tyrosine import", "up regulation of L-tyrosine import", "positive regulation of L-tyrosine import", "upregulation of L-tyrosine import"], "types": ["T044"], "canonical_name": "positive regulation of L-tyrosine import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of L-tyrosine import into the cell. [GOC:TermGenie]"}
{"concept_id": "C3547774", "aliases": ["regulation of L-tyrosine uptake", "regulation of L-tyrosine import"], "types": ["T044"], "canonical_name": "regulation of L-tyrosine import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of L-tyrosine import into the cell. [GOC:TermGenie]"}
{"concept_id": "C3547775", "aliases": ["positive regulation of L-threonine import", "upregulation of L-threonine import", "up regulation of L-threonine import", "up-regulation of L-threonine import"], "types": ["T044"], "canonical_name": "positive regulation of L-threonine import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of L-threonine import into cell. [GOC:TermGenie]"}
{"concept_id": "C3547776", "aliases": ["regulation of L-threonine uptake", "regulation of L-threonine import"], "types": ["T044"], "canonical_name": "regulation of L-threonine import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of L-threonine import into cell. [GOC:TermGenie]"}
{"concept_id": "C3547777", "aliases": ["up regulation of glycine import", "up-regulation of glycine import", "upregulation of glycine import", "positive regulation of glycine import"], "types": ["T044"], "canonical_name": "positive regulation of glycine import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of glycine import. [GOC:TermGenie]"}
{"concept_id": "C3547778", "aliases": ["down regulation of glycine import", "down-regulation of glycine import", "downregulation of glycine import", "negative regulation of glycine import"], "types": ["T044"], "canonical_name": "negative regulation of glycine import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell. [GOC:TermGenie]"}
{"concept_id": "C3547779", "aliases": [], "types": ["T044"], "canonical_name": "regulation of glycine import"}
{"concept_id": "C3547781", "aliases": ["up-regulation of octadecene metabolic process", "up regulation of octadecene metabolic process", "upregulation of octadecene metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of octadecene metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of octadecene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547782", "aliases": ["down-regulation of octadecene metabolic process", "down regulation of octadecene metabolic process", "downregulation of octadecene metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of octadecene metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547783", "aliases": ["regulation of octadecene metabolism"], "types": ["T044"], "canonical_name": "regulation of octadecene metabolic process", "definition": "Any process that modulates the frequency, rate or extent of octadecene metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547784", "aliases": ["up regulation of octadecene biosynthetic process", "up-regulation of octadecene biosynthetic process", "upregulation of octadecene biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of octadecene biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of octadecene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547785", "aliases": ["down-regulation of octadecene biosynthetic process", "down regulation of octadecene biosynthetic process", "downregulation of octadecene biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of octadecene biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547786", "aliases": ["regulation of 1-octadecene biosynthetic process", "regulation of octadecene biosynthesis", "regulation of octadecene formation", "regulation of octadecene synthesis", "regulation of octadecene anabolism"], "types": ["T044"], "canonical_name": "regulation of octadecene biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of octadecene biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547787", "aliases": ["up-regulation of olefin biosynthetic process", "upregulation of olefin biosynthetic process", "up regulation of olefin biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of olefin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of olefin biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547788", "aliases": ["down-regulation of olefin biosynthetic process", "downregulation of olefin biosynthetic process", "down regulation of olefin biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of olefin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of olefin biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547789", "aliases": ["regulation of olefin anabolism", "regulation of olefin synthesis", "regulation of olefin biosynthesis", "regulation of olefin formation"], "types": ["T044"], "canonical_name": "regulation of olefin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of olefin biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547790", "aliases": ["upregulation of olefin metabolic process", "up regulation of olefin metabolic process", "up-regulation of olefin metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of olefin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of olefin metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547791", "aliases": ["down-regulation of olefin metabolic process", "downregulation of olefin metabolic process", "down regulation of olefin metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of olefin metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of olefin metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547792", "aliases": ["regulation of olefin metabolism"], "types": ["T044"], "canonical_name": "regulation of olefin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of olefin metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547793", "aliases": ["upregulation of hexadecanal metabolic process", "up-regulation of hexadecanal metabolic process", "up regulation of hexadecanal metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of hexadecanal metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of hexadecanal metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547794", "aliases": ["downregulation of hexadecanal metabolic process", "down-regulation of hexadecanal metabolic process", "down regulation of hexadecanal metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of hexadecanal metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547795", "aliases": ["regulation of hexadecanal metabolism"], "types": ["T044"], "canonical_name": "regulation of hexadecanal metabolic process", "definition": "Any process that modulates the frequency, rate or extent of hexadecanal metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547796", "aliases": ["down regulation of hexadecanal biosynthetic process", "downregulation of hexadecanal biosynthetic process", "down-regulation of hexadecanal biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of hexadecanal biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547797", "aliases": ["regulation of hexadecanal synthesis", "regulation of palmitaldehyde biosynthesis", "regulation of hexadecanal formation", "regulation of palmitaldehyde biosynthetic process", "regulation of hexadecanal anabolism", "regulation of hexadecanal biosynthesis"], "types": ["T044"], "canonical_name": "regulation of hexadecanal biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of hexadecanal biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547798", "aliases": ["up-regulation of heptadecane metabolic process", "up regulation of heptadecane metabolic process", "upregulation of heptadecane metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of heptadecane metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of heptadecane metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547799", "aliases": ["down regulation of heptadecane metabolic process", "down-regulation of heptadecane metabolic process", "downregulation of heptadecane metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of heptadecane metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547800", "aliases": ["regulation of heptadecane metabolism"], "types": ["T044"], "canonical_name": "regulation of heptadecane metabolic process", "definition": "Any process that modulates the frequency, rate or extent of heptadecane metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547801", "aliases": ["up regulation of heptadecane biosynthetic process", "up-regulation of heptadecane biosynthetic process", "upregulation of heptadecane biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of heptadecane biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of heptadecane biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547802", "aliases": ["downregulation of heptadecane biosynthetic process", "down regulation of heptadecane biosynthetic process", "down-regulation of heptadecane biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of heptadecane biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547803", "aliases": ["regulation of heptadecane biosynthesis", "regulation of heptadecane synthesis", "regulation of heptadecane anabolism", "regulation of heptadecane formation"], "types": ["T044"], "canonical_name": "regulation of heptadecane biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of heptadecane biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547804", "aliases": ["up regulation of tridecane metabolic process", "up-regulation of tridecane metabolic process", "upregulation of tridecane metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of tridecane metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of tridecane metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547805", "aliases": ["down regulation of tridecane metabolic process", "down-regulation of tridecane metabolic process", "downregulation of tridecane metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of tridecane metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547806", "aliases": ["regulation of tridecane metabolism"], "types": ["T044"], "canonical_name": "regulation of tridecane metabolic process", "definition": "Any process that modulates the frequency, rate or extent of tridecane metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547807", "aliases": ["upregulation of pentadecane metabolic process", "up regulation of pentadecane metabolic process", "up-regulation of pentadecane metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of pentadecane metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of pentadecane metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547808", "aliases": ["down-regulation of pentadecane metabolic process", "downregulation of pentadecane metabolic process", "down regulation of pentadecane metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of pentadecane metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547809", "aliases": ["regulation of pentadecane metabolism"], "types": ["T044"], "canonical_name": "regulation of pentadecane metabolic process", "definition": "Any process that modulates the frequency, rate or extent of pentadecane metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547810", "aliases": ["up-regulation of pentadecane biosynthetic process", "up regulation of pentadecane biosynthetic process", "upregulation of pentadecane biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of pentadecane biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of pentadecane biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547811", "aliases": ["down-regulation of pentadecane biosynthetic process", "down regulation of pentadecane biosynthetic process", "downregulation of pentadecane biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of pentadecane biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547812", "aliases": ["regulation of pentadecane anabolism", "regulation of pentadecane synthesis", "regulation of pentadecane biosynthesis", "regulation of pentadecane formation"], "types": ["T044"], "canonical_name": "regulation of pentadecane biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of pentadecane biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547813", "aliases": ["positive regulation of tridecane formation", "up-regulation of tridecane biosynthesis", "upregulation of tridecane formation", "up-regulation of tridecane anabolism", "up-regulation of tridecane biosynthetic process", "positive regulation of tridecane anabolism", "upregulation of tridecane biosynthesis", "up regulation of tridecane synthesis", "up regulation of tridecane anabolism", "positive regulation of tridecane biosynthesis", "up regulation of tridecane biosynthetic process", "up regulation of tridecane formation", "up-regulation of tridecane synthesis", "upregulation of tridecane biosynthetic process", "up-regulation of tridecane formation", "up regulation of tridecane biosynthesis", "upregulation of tridecane anabolism", "positive regulation of tridecane synthesis", "upregulation of tridecane synthesis"], "types": ["T044"], "canonical_name": "positive regulation of tridecane biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of tridecane biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547814", "aliases": ["down regulation of tridecane biosynthesis", "down-regulation of tridecane biosynthesis", "downregulation of tridecane biosynthetic process", "downregulation of tridecane synthesis", "negative regulation of tridecane anabolism", "down-regulation of tridecane formation", "downregulation of tridecane biosynthesis", "down regulation of tridecane anabolism", "down-regulation of tridecane biosynthetic process", "down regulation of tridecane formation", "negative regulation of tridecane synthesis", "down regulation of tridecane biosynthetic process", "down-regulation of tridecane anabolism", "downregulation of tridecane anabolism", "down regulation of tridecane synthesis", "down-regulation of tridecane synthesis", "negative regulation of tridecane formation", "downregulation of tridecane formation", "negative regulation of tridecane biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of tridecane biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547815", "aliases": ["regulation of tridecane anabolism", "regulation of tridecane biosynthesis", "regulation of tridecane formation", "regulation of tridecane synthesis"], "types": ["T044"], "canonical_name": "regulation of tridecane biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of tridecane biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547816", "aliases": ["17-methylnonadec-1-ene anabolism", "17-methylnonadec-1-ene biosynthesis", "17-methylnonadec-1-ene synthesis", "17-methylnonadec-1-ene formation"], "types": ["T044"], "canonical_name": "17-methylnonadec-1-ene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 17-methylnonadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547817", "aliases": ["17-methylnonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "17-methylnonadec-1-ene metabolic process", "definition": "The chemical reactions and pathways involving 17-methylnonadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547818", "aliases": ["18-methylnonadec-1-ene anabolism", "18-methylnonadec-1-ene biosynthesis", "18-methylnonadec-1-ene formation", "18-methylnonadec-1-ene synthesis"], "types": ["T044"], "canonical_name": "18-methylnonadec-1-ene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 18-methylnonadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547819", "aliases": ["18-methylnonadec-1-ene metabolism"], "types": ["T044"], "canonical_name": "18-methylnonadec-1-ene metabolic process", "definition": "The chemical reactions and pathways involving 18-methylnonadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547820", "aliases": ["(Z)-nonadeca-1,14-diene anabolism", "(Z)-nonadeca-1,14-diene biosynthesis", "(Z)-nonadeca-1,14-diene synthesis", "(Z)-nonadeca-1,14-diene formation"], "types": ["T044"], "canonical_name": "(Z)-nonadeca-1,14-diene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (Z)-nonadeca-1,14-diene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547821", "aliases": ["(Z)-nonadeca-1,14-diene metabolism"], "types": ["T044"], "canonical_name": "(Z)-nonadeca-1,14-diene metabolic process", "definition": "The chemical reactions and pathways involving (Z)-nonadeca-1,14-diene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547822", "aliases": ["nonadec-1-ene anabolism", "nonadec-1-ene biosynthesis", "nonadec-1-ene formation", "nonadec-1-ene synthesis"], "types": ["T044"], "canonical_name": "nonadec-1-ene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of nonadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547823", "aliases": ["nonadec-1-ene metabolism"], "types": ["T043"], "canonical_name": "nonadec-1-ene metabolic process", "definition": "The chemical reactions and pathways involving nonadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547824", "aliases": ["heptadec-1-ene synthesis", "heptadec-1-ene formation", "heptadec-1-ene anabolism", "heptadec-1-ene biosynthesis"], "types": ["T044"], "canonical_name": "heptadec-1-ene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of heptadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547825", "aliases": ["heptadec-1-ene metabolism"], "types": ["T043"], "canonical_name": "heptadec-1-ene metabolic process", "definition": "The chemical reactions and pathways involving heptadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547826", "aliases": ["pentadec-1-ene biosynthesis", "pentadec-1-ene anabolism", "pentadec-1-ene synthesis", "pentadec-1-ene formation"], "types": ["T044"], "canonical_name": "pentadec-1-ene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pentadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547827", "aliases": ["pentadec-1-ene metabolism"], "types": ["T043"], "canonical_name": "pentadec-1-ene metabolic process", "definition": "The chemical reactions and pathways involving pentadec-1-ene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547828", "aliases": [], "types": ["T045"], "canonical_name": "chloroplast mRNA modification", "definition": "The covalent alteration within the chloroplast of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically. [GOC:TermGenie, PMID:1653905]"}
{"concept_id": "C3547829", "aliases": ["tatiopterin anabolism", "tatiopterin biosynthesis", "tatiopterin synthesis", "tatiopterin formation"], "types": ["T044"], "canonical_name": "tatiopterin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tatiopterin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547830", "aliases": ["tatiopterin metabolism"], "types": ["T044"], "canonical_name": "tatiopterin metabolic process", "definition": "The chemical reactions and pathways involving tatiopterin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547831", "aliases": ["sarcinapterin anabolism", "sarcinapterin synthesis", "sarcinapterin biosynthesis", "sarcinapterin formation"], "types": ["T044"], "canonical_name": "sarcinapterin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sarcinapterin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547832", "aliases": ["sarcinapterin metabolism"], "types": ["T044"], "canonical_name": "sarcinapterin metabolic process", "definition": "The chemical reactions and pathways involving sarcinapterin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547833", "aliases": [], "types": ["T043"], "canonical_name": "glycolate transport", "definition": "The directed movement of a glycolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3547834", "aliases": [], "types": ["T045"], "canonical_name": "chloroplast RNA modification", "definition": "Any RNA modification that takes place in chloroplast. [GOC:TermGenie]"}
{"concept_id": "C3547835", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial RNA modification", "definition": "Any RNA modification that takes place in mitochondrion. [GOC:TermGenie]"}
{"concept_id": "C3547836", "aliases": ["downregulation of cordyol C biosynthetic process", "down-regulation of cordyol C biosynthetic process", "down regulation of cordyol C biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of cordyol C biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cordyol C biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547837", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cordyol C biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of cordyol C biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547838", "aliases": ["upregulation of brevianamide F biosynthetic process", "up regulation of brevianamide F biosynthetic process", "up-regulation of brevianamide F biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of brevianamide F biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of brevianamide F biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547839", "aliases": ["down regulation of brevianamide F biosynthetic process", "downregulation of brevianamide F biosynthetic process", "down-regulation of brevianamide F biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of brevianamide F biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of brevianamide F biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547840", "aliases": ["regulation of brevianamide F formation", "regulation of brevianamide F anabolism", "regulation of brevianamide F synthesis", "regulation of brevianamide F biosynthesis"], "types": ["T044"], "canonical_name": "regulation of brevianamide F biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of brevianamide F biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547841", "aliases": ["upregulation of fumitremorgin B biosynthetic process", "up regulation of fumitremorgin B biosynthetic process", "up-regulation of fumitremorgin B biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of fumitremorgin B biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of fumitremorgin B biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547842", "aliases": ["downregulation of fumitremorgin B biosynthetic process", "down-regulation of fumitremorgin B biosynthetic process", "down regulation of fumitremorgin B biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of fumitremorgin B biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fumitremorgin B biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547843", "aliases": ["regulation of fumitremorgin B anabolism", "regulation of fumitremorgin B biosynthesis", "regulation of fumitremorgin B synthesis", "regulation of fumitremorgin B formation"], "types": ["T044"], "canonical_name": "regulation of fumitremorgin B biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of fumitremorgin B biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547844", "aliases": ["up regulation of terrequinone A biosynthetic process", "up-regulation of terrequinone A biosynthetic process", "upregulation of terrequinone A biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of terrequinone A biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of terrequinone A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547845", "aliases": ["down regulation of terrequinone A biosynthetic process", "downregulation of terrequinone A biosynthetic process", "down-regulation of terrequinone A biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of terrequinone A biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of terrequinone A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547846", "aliases": ["regulation of terrequinone A anabolism", "regulation of terrequinone A synthesis", "regulation of terrequinone A formation", "regulation of terrequinone A biosynthesis"], "types": ["T044"], "canonical_name": "regulation of terrequinone A biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of terrequinone A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547847", "aliases": ["up-regulation of pseurotin A biosynthetic process", "up regulation of pseurotin A biosynthetic process", "upregulation of pseurotin A biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of pseurotin A biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547848", "aliases": ["down-regulation of pseurotin A biosynthetic process", "downregulation of pseurotin A biosynthetic process", "down regulation of pseurotin A biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of pseurotin A biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pseurotin A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547849", "aliases": ["regulation of pseurotin A biosynthesis", "regulation of pseurotin A anabolism", "regulation of pseurotin A formation", "regulation of pseurotin A synthesis"], "types": ["T044"], "canonical_name": "regulation of pseurotin A biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of pseurotin A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547850", "aliases": ["down regulation of naphtho-gamma-pyrone biosynthetic process", "down-regulation of naphtho-gamma-pyrone biosynthetic process", "downregulation of naphtho-gamma-pyrone biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of naphtho-gamma-pyrone biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547851", "aliases": ["regulation of naphtho-gamma-pyrones synthesis", "regulation of naphtho-gamma-pyrone anabolism", "regulation of naphtho-gamma-pyrone synthesis", "regulation of naphtho-gamma-pyrone biosynthesis", "regulation of naphtho-gamma-pyrones formation", "regulation of naphtho-gamma-pyrones anabolism", "regulation of naphtho-gamma-pyrones biosynthesis", "regulation of naphtho-gamma-pyrones biosynthetic process", "regulation of naphtho-gamma-pyrone formation"], "types": ["T044"], "canonical_name": "regulation of naphtho-gamma-pyrone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547852", "aliases": ["upregulation of monodictyphenone biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of monodictyphenone biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of monodictyphenone biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547853", "aliases": ["down-regulation of monodictyphenone biosynthetic process", "downregulation of monodictyphenone biosynthetic process", "down regulation of monodictyphenone biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of monodictyphenone biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of monodictyphenone biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547854", "aliases": ["regulation of monodictyphenone synthesis", "regulation of monodictyphenone formation", "regulation of monodictyphenone anabolism", "regulation of monodictyphenone biosynthesis"], "types": ["T040"], "canonical_name": "regulation of monodictyphenone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of monodictyphenone biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547855", "aliases": ["upregulation of helvolic acid biosynthetic process", "up regulation of helvolic acid biosynthetic process", "up-regulation of helvolic acid biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of helvolic acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of helvolic acid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547856", "aliases": ["down-regulation of helvolic acid biosynthetic process", "down regulation of helvolic acid biosynthetic process", "downregulation of helvolic acid biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of helvolic acid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of helvolic acid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547857", "aliases": [], "types": ["T040"], "canonical_name": "regulation of helvolic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of helvolic acid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547858", "aliases": ["upregulation of fumigaclavine C biosynthetic process", "up-regulation of fumigaclavine C biosynthetic process", "up regulation of fumigaclavine C biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of fumigaclavine C biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of fumigaclavine C biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547859", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of fumigaclavine C biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fumigaclavine C biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547860", "aliases": ["regulation of fumigaclavine C formation", "regulation of fumigaclavine C biosynthesis", "regulation of fumigaclavine C anabolism", "regulation of fumigaclavine C synthesis"], "types": ["T044"], "canonical_name": "regulation of fumigaclavine C biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of fumigaclavine C biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547861", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of emericellin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of emericellin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547862", "aliases": ["downregulation of emericellin biosynthetic process", "down regulation of emericellin biosynthetic process", "down-regulation of emericellin biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of emericellin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of emericellin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547863", "aliases": ["regulation of emericellin biosynthesis", "regulation of emericellin formation", "regulation of emericellin anabolism", "regulation of emericellin synthesis"], "types": ["T044"], "canonical_name": "regulation of emericellin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of emericellin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547864", "aliases": ["D-leucine biosynthesis", "D-leucine formation", "D-leucine synthesis", "D-leucine anabolism"], "types": ["T044"], "canonical_name": "D-leucine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of D-leucine. [GOC:TermGenie, PMID:10918062]"}
{"concept_id": "C3547865", "aliases": ["D-leucine degradation", "D-leucine catabolism", "D-leucine breakdown"], "types": ["T044"], "canonical_name": "D-leucine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-leucine. [GOC:TermGenie, PMID:10918062]"}
{"concept_id": "C3547866", "aliases": ["D-leucine metabolism"], "types": ["T044"], "canonical_name": "D-leucine metabolic process", "definition": "The chemical reactions and pathways involving D-leucine. [GOC:TermGenie, PMID:10918062]"}
{"concept_id": "C3547868", "aliases": ["D-tyrosine breakdown", "D-tyrosine degradation", "D-tyrosine catabolism"], "types": ["T044"], "canonical_name": "D-tyrosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-tyrosine. [GOC:TermGenie, PMID:10766779]"}
{"concept_id": "C3547869", "aliases": ["D-tyrosine metabolism"], "types": ["T044"], "canonical_name": "D-tyrosine metabolic process", "definition": "The chemical reactions and pathways involving D-tyrosine. [GOC:TermGenie, PMID:10766779]"}
{"concept_id": "C3547870", "aliases": ["upregulation of membrane depolarization during cardiac muscle cell action potential", "up regulation of membrane depolarization during cardiac muscle cell action potential", "up-regulation of membrane depolarization during cardiac muscle cell action potential"], "types": ["T039"], "canonical_name": "positive regulation of membrane depolarization during cardiac muscle cell action potential", "definition": "Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]"}
{"concept_id": "C3547871", "aliases": ["downregulation of membrane depolarization during cardiac muscle cell action potential", "down regulation of membrane depolarization during cardiac muscle cell action potential", "down-regulation of membrane depolarization during of cardiac muscle cell action potential"], "types": ["T039"], "canonical_name": "negative regulation of membrane depolarization during cardiac muscle cell action potential", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]"}
{"concept_id": "C3547872", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane depolarization during cardiac muscle cell action potential", "definition": "Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]"}
{"concept_id": "C3547873", "aliases": ["down regulation of ergot alkaloid anabolism", "down regulation of ergot alkaloid formation", "downregulation of ergot alkaloid anabolism", "down regulation of ergot alkaloid synthesis", "down regulation of ergot alkaloid biosynthesis", "inhibition of ergot alkaloid synthesis", "negative regulation of ergot alkaloid anabolism", "down-regulation of ergot alkaloid formation", "down-regulation of ergot alkaloid synthesis", "down-regulation of ergot alkaloid anabolism", "inhibition of ergot alkaloid anabolism", "negative regulation of ergot alkaloid formation", "inhibition of ergot alkaloid biosynthesis", "inhibition of ergot alkaloid formation", "downregulation of ergot alkaloid formation", "down-regulation of ergot alkaloid biosynthetic process", "negative regulation of ergot alkaloid synthesis", "down-regulation of ergot alkaloid biosynthesis", "down regulation of ergot alkaloid biosynthetic process", "downregulation of ergot alkaloid synthesis", "downregulation of ergot alkaloid biosynthetic process", "negative regulation of ergot alkaloid biosynthesis", "downregulation of ergot alkaloid biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of ergot alkaloid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ergot alkaloid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547874", "aliases": ["regulation of ergot alkaloid synthesis", "regulation of ergot alkaloid biosynthesis", "regulation of ergot alkaloid anabolism", "regulation of ergot alkaloid formation"], "types": ["T043"], "canonical_name": "regulation of ergot alkaloid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of ergot alkaloid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547875", "aliases": ["orlandin catabolism", "orlandin degradation", "orlandin breakdown"], "types": ["T044"], "canonical_name": "orlandin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of orlandin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547876", "aliases": ["orlandin metabolism"], "types": ["T044"], "canonical_name": "orlandin metabolic process", "definition": "The chemical reactions and pathways involving orlandin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547877", "aliases": ["Ochratoxin A synthesis", "Ochratoxin A anabolism", "Ochratoxin A biosynthesis", "Ochratoxin A formation"], "types": ["T044"], "canonical_name": "ochratoxin A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ochratoxin A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547878", "aliases": ["ochratoxin A catabolism", "ochratoxin A breakdown", "ochratoxin A degradation"], "types": ["T044"], "canonical_name": "ochratoxin A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ochratoxin A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547879", "aliases": ["Ochratoxin A metabolism"], "types": ["T044"], "canonical_name": "ochratoxin A metabolic process", "definition": "The chemical reactions and pathways involving ochratoxin A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547880", "aliases": ["monodictyphenone anabolism", "monodictyphenone formation", "monodictyphenone biosynthesis", "monodictyphenone synthesis"], "types": ["T044"], "canonical_name": "monodictyphenone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of monodictyphenone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547881", "aliases": ["monodictyphenone breakdown", "monodictyphenone catabolism", "monodictyphenone degradation"], "types": ["T044"], "canonical_name": "monodictyphenone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of monodictyphenone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547882", "aliases": ["monodictyphenone metabolism"], "types": ["T044"], "canonical_name": "monodictyphenone metabolic process", "definition": "The chemical reactions and pathways involving monodictyphenone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547883", "aliases": ["helvolic acid formation", "helvolic acid synthesis", "helvolic acid anabolism", "helvolic acid biosynthesis"], "types": ["T044"], "canonical_name": "helvolic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of helvolic acid. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547884", "aliases": ["fumigaclavine C synthesis", "fumigaclavine C biosynthesis", "fumigaclavine C anabolism", "fumigaclavine C formation"], "types": ["T044"], "canonical_name": "fumigaclavine C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumigaclavine C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547885", "aliases": ["fumigaclavine C catabolism", "fumigaclavine C breakdown", "fumigaclavine C degradation"], "types": ["T044"], "canonical_name": "fumigaclavine C catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fumigaclavine C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547886", "aliases": ["fumigaclavine C metabolism"], "types": ["T044"], "canonical_name": "fumigaclavine C metabolic process", "definition": "The chemical reactions and pathways involving fumigaclavine C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547887", "aliases": ["ergot alkaloids degradation", "ergot alkaloid catabolism", "ergot alkaloids breakdown", "ergot alkaloid degradation", "ergot alkaloids catabolism", "ergot alkaloids catabolic process", "ergot alkaloid breakdown"], "types": ["T044"], "canonical_name": "ergot alkaloid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ergot alkaloid. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547888", "aliases": ["brevianamide F biosynthesis", "brevianamide F anabolism", "brevianamide F synthesis", "brevianamide F formation"], "types": ["T044"], "canonical_name": "brevianamide F biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of brevianamide F. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547889", "aliases": ["brevianamide F degradation", "brevianamide F breakdown", "brevianamide F catabolism"], "types": ["T044"], "canonical_name": "brevianamide F catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of brevianamide F. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547890", "aliases": ["brevianamide F metabolism"], "types": ["T044"], "canonical_name": "brevianamide F metabolic process", "definition": "The chemical reactions and pathways involving brevianamide F. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547891", "aliases": ["cspyrone B1 biosynthesis", "cspyrone B1 synthesis", "cspyrone B1 anabolism", "cspyrone B1 formation"], "types": ["T044"], "canonical_name": "cspyrone B1 biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cspyrone B1. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547892", "aliases": ["cspyrone B1 breakdown", "cspyrone B1 catabolism", "cspyrone B1 degradation"], "types": ["T044"], "canonical_name": "cspyrone B1 catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cspyrone B1. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547893", "aliases": ["cspyrone B1 metabolism"], "types": ["T044"], "canonical_name": "cspyrone B1 metabolic process", "definition": "The chemical reactions and pathways involving cspyrone B1. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547894", "aliases": ["cordyol C synthesis", "cordyol C anabolism", "cordyol C formation", "cordyol C biosynthesis"], "types": ["T044"], "canonical_name": "cordyol C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cordyol C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547895", "aliases": ["cordyol C breakdown", "cordyol C degradation", "cordyol C catabolism"], "types": ["T044"], "canonical_name": "cordyol C catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cordyol C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547896", "aliases": ["cordyol C metabolism"], "types": ["T044"], "canonical_name": "cordyol C metabolic process", "definition": "The chemical reactions and pathways involving cordyol C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547897", "aliases": ["terrequinone A anabolism", "terrequinone A synthesis", "terrequinone A formation", "terrequinone A biosynthesis"], "types": ["T044"], "canonical_name": "terrequinone A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of terrequinone A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547898", "aliases": ["terrequinone A breakdown", "terrequinone A catabolism", "terrequinone A degradation"], "types": ["T044"], "canonical_name": "terrequinone A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of terrequinone A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547899", "aliases": ["terrequinone A metabolism"], "types": ["T044"], "canonical_name": "terrequinone A metabolic process", "definition": "The chemical reactions and pathways involving terrequinone A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547900", "aliases": ["shamixanthone anabolism", "shamixanthone formation", "shamixanthone biosynthesis", "shamixanthone synthesis"], "types": ["T044"], "canonical_name": "shamixanthone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of shamixanthone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547901", "aliases": ["shamixanthone breakdown", "shamixanthone degradation", "shamixanthone catabolism"], "types": ["T044"], "canonical_name": "shamixanthone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of shamixanthone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547902", "aliases": ["shamixanthone metabolism"], "types": ["T044"], "canonical_name": "shamixanthone metabolic process", "definition": "The chemical reactions and pathways involving shamixanthone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547903", "aliases": ["pseurotin A synthesis", "pseurotin A biosynthesis", "pseurotin A formation", "pseurotin A anabolism"], "types": ["T044"], "canonical_name": "pseurotin A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pseurotin A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547904", "aliases": ["pseurotin A degradation", "pseurotin A breakdown", "pseurotin A catabolism"], "types": ["T044"], "canonical_name": "pseurotin A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pseurotin A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547905", "aliases": ["pseurotin A metabolism"], "types": ["T044"], "canonical_name": "pseurotin A metabolic process", "definition": "The chemical reactions and pathways involving pseurotin A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547906", "aliases": ["naphtho-gamma-pyrone biosynthesis", "naphtho-gamma-pyrones formation", "naphtho-gamma-pyrones anabolism", "naphtho-gamma-pyrones synthesis", "naphtho-gamma-pyrone formation", "naphtho-gamma-pyrones biosynthetic process", "naphtho-gamma-pyrone anabolism", "naphtho-gamma-pyrone synthesis", "naphtho-gamma-pyrones biosynthesis"], "types": ["T044"], "canonical_name": "naphtho-gamma-pyrone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of naphtho-gamma-pyrone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547907", "aliases": ["naphtho-gamma-pyrone degradation", "naphtho-gamma-pyrones degradation", "naphtho-gamma-pyrone breakdown", "naphtho-gamma-pyrones catabolism", "naphtho-gamma-pyrone catabolism", "naphtho-gamma-pyrones breakdown", "naphtho-gamma-pyrones catabolic process"], "types": ["T044"], "canonical_name": "naphtho-gamma-pyrone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of naphtho-gamma-pyrone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547908", "aliases": ["naphtho-gamma-pyrone metabolism", "naphtho-gamma-pyrones metabolic process", "naphtho-gamma-pyrones metabolism"], "types": ["T044"], "canonical_name": "naphtho-gamma-pyrone metabolic process", "definition": "The chemical reactions and pathways involving naphtho-gamma-pyrone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547909", "aliases": ["fumiquinazoline F synthesis", "fumiquinazoline F formation", "fumiquinazoline F anabolism", "fumiquinazoline F biosynthesis"], "types": ["T044"], "canonical_name": "fumiquinazoline F biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumiquinazoline F. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547910", "aliases": ["fumiquinazoline F degradation", "fumiquinazoline F breakdown", "fumiquinazoline F catabolism"], "types": ["T044"], "canonical_name": "fumiquinazoline F catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline F. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547911", "aliases": ["fumiquinazoline F metabolism"], "types": ["T044"], "canonical_name": "fumiquinazoline F metabolic process", "definition": "The chemical reactions and pathways involving fumiquinazoline F. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547912", "aliases": ["fumiquinazoline C formation", "fumiquinazoline C biosynthesis", "fumiquinazoline C anabolism", "fumiquinazoline C synthesis"], "types": ["T044"], "canonical_name": "fumiquinazoline C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumiquinazoline C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547913", "aliases": ["fumiquinazoline C breakdown", "fumiquinazoline C degradation", "fumiquinazoline C catabolism"], "types": ["T044"], "canonical_name": "fumiquinazoline C catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547914", "aliases": ["fumiquinazoline C metabolism"], "types": ["T044"], "canonical_name": "fumiquinazoline C metabolic process", "definition": "The chemical reactions and pathways involving fumiquinazoline C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547915", "aliases": ["fumiquinazoline A synthesis", "fumiquinazoline A formation", "fumiquinazoline A anabolism", "fumiquinazoline A biosynthesis"], "types": ["T044"], "canonical_name": "fumiquinazoline A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumiquinazoline A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547916", "aliases": ["fumiquinazoline A breakdown", "fumiquinazoline A catabolism", "fumiquinazoline A degradation"], "types": ["T044"], "canonical_name": "fumiquinazoline A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547917", "aliases": ["fumiquinazoline A metabolism"], "types": ["T044"], "canonical_name": "fumiquinazoline A metabolic process", "definition": "The chemical reactions and pathways involving fumiquinazoline A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547918", "aliases": ["fumiquinazoline formation", "fumiquinazoline synthesis", "fumiquinazolines anabolism", "fumiquinazolines biosynthetic process", "fumiquinazolines synthesis", "fumiquinazolines formation", "fumiquinazolines biosynthesis", "fumiquinazoline biosynthesis", "fumiquinazoline anabolism"], "types": ["T044"], "canonical_name": "fumiquinazoline biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumiquinazoline. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547919", "aliases": ["fumiquinazolines catabolism", "fumiquinazoline degradation", "fumiquinazolines breakdown", "fumiquinazoline catabolism", "fumiquinazolines catabolic process", "fumiquinazolines degradation", "fumiquinazoline breakdown"], "types": ["T044"], "canonical_name": "fumiquinazoline catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547920", "aliases": ["fumiquinazolines metabolic process", "fumiquinazolines metabolism", "fumiquinazoline metabolism"], "types": ["T044"], "canonical_name": "fumiquinazoline metabolic process", "definition": "The chemical reactions and pathways involving fumiquinazoline. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547921", "aliases": ["fumitremorgin B formation", "fumitremorgin B anabolism", "fumitremorgin B biosynthesis", "fumitremorgin B synthesis"], "types": ["T044"], "canonical_name": "fumitremorgin B biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumitremorgin B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547922", "aliases": ["fumitremorgin B degradation", "fumitremorgin B breakdown", "fumitremorgin B catabolism"], "types": ["T044"], "canonical_name": "fumitremorgin B catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fumitremorgin B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547923", "aliases": ["fonsecin formation", "fonsecin synthesis", "fonsecin anabolism", "fonsecin biosynthesis"], "types": ["T044"], "canonical_name": "fonsecin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fonsecin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547924", "aliases": ["fonsecin catabolism", "fonsecin degradation", "fonsecin breakdown"], "types": ["T044"], "canonical_name": "fonsecin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fonsecin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547925", "aliases": ["fonsecin metabolism"], "types": ["T044"], "canonical_name": "fonsecin metabolic process", "definition": "The chemical reactions and pathways involving fonsecin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547926", "aliases": ["emericellin synthesis", "emericellin anabolism", "emericellin biosynthesis", "emericellin formation"], "types": ["T044"], "canonical_name": "emericellin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of emericellin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547927", "aliases": ["emericellin catabolism", "emericellin breakdown", "emericellin degradation"], "types": ["T044"], "canonical_name": "emericellin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of emericellin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547928", "aliases": ["emericellin metabolism"], "types": ["T044"], "canonical_name": "emericellin metabolic process", "definition": "The chemical reactions and pathways involving emericellin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547929", "aliases": ["averantin formation", "averantin synthesis", "averantin biosynthesis", "averantin anabolism"], "types": ["T044"], "canonical_name": "averantin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of averantin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547930", "aliases": ["averantin degradation", "averantin breakdown", "averantin catabolism"], "types": ["T044"], "canonical_name": "averantin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of averantin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547931", "aliases": ["averantin metabolism"], "types": ["T044"], "canonical_name": "averantin metabolic process", "definition": "The chemical reactions and pathways involving averantin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547932", "aliases": ["down regulation of sterigmatocystin biosynthetic process", "negative regulation of sterigmatocystin synthesis", "downregulation of sterigmatocystin biosynthetic process", "down-regulation of sterigmatocystin anabolism", "inhibition of sterigmatocystin biosynthesis", "down regulation of sterigmatocystin biosynthesis", "negative regulation of sterigmatocystin formation", "downregulation of sterigmatocystin anabolism", "down-regulation of sterigmatocystin synthesis", "down-regulation of sterigmatocystin formation", "negative regulation of sterigmatocystin biosynthesis", "down-regulation of sterigmatocystin biosynthetic process", "downregulation of sterigmatocystin biosynthesis", "inhibition of sterigmatocystin synthesis", "inhibition of sterigmatocystin formation", "downregulation of sterigmatocystin synthesis", "down-regulation of sterigmatocystin biosynthesis", "downregulation of sterigmatocystin formation", "down regulation of sterigmatocystin synthesis", "down regulation of sterigmatocystin anabolism", "inhibition of sterigmatocystin anabolism", "negative regulation of sterigmatocystin anabolism", "down regulation of sterigmatocystin formation"], "types": ["T044"], "canonical_name": "negative regulation of sterigmatocystin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sterigmatocystin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547933", "aliases": ["upregulation of D-amino-acid oxidase activity", "up-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)", "upregulation of D-amino-acid:oxygen oxidoreductase (deaminating)", "up regulation of D-amino-acid:oxygen oxidoreductase (deaminating)", "positive regulation of L-amino acid:O2 oxidoreductase activity", "up regulation of D-amino-acid oxidase activity", "up-regulation of D-amino-acid oxidase activity", "activation of D-amino-acid:oxygen oxidoreductase (deaminating)", "upregulation of L-amino acid:O2 oxidoreductase activity", "activation of L-amino acid:O2 oxidoreductase activity", "positive regulation of D-amino-acid:oxygen oxidoreductase (deaminating)", "up regulation of L-amino acid:O2 oxidoreductase activity", "up-regulation of L-amino acid:O2 oxidoreductase activity"], "types": ["T044"], "canonical_name": "positive regulation of D-amino-acid oxidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of D-amino-acid oxidase activity. [GOC:TermGenie]"}
{"concept_id": "C3547934", "aliases": ["downregulation of D-amino-acid:oxygen oxidoreductase (deaminating)", "inhibition of D-amino-acid:oxygen oxidoreductase (deaminating)", "down-regulation of D-amino-acid oxidase activity", "down-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)", "downregulation of D-amino-acid oxidase activity", "negative regulation of L-amino acid:O2 oxidoreductase activity", "inhibition of L-amino acid:O2 oxidoreductase activity", "down regulation of D-amino-acid oxidase activity", "downregulation of L-amino acid:O2 oxidoreductase activity", "down regulation of L-amino acid:O2 oxidoreductase activity", "negative regulation of D-amino-acid:oxygen oxidoreductase (deaminating)", "down-regulation of L-amino acid:O2 oxidoreductase activity", "down regulation of D-amino-acid:oxygen oxidoreductase (deaminating)"], "types": ["T044"], "canonical_name": "negative regulation of D-amino-acid oxidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of D-amino-acid oxidase activity. [GOC:TermGenie]"}
{"concept_id": "C3547935", "aliases": ["regulation of D-amino-acid:oxygen oxidoreductase (deaminating)", "regulation of L-amino acid:O2 oxidoreductase activity"], "types": ["T044"], "canonical_name": "regulation of D-amino-acid oxidase activity", "definition": "Any process that modulates the frequency, rate or extent of D-amino-acid oxidase activity. [GOC:TermGenie]"}
{"concept_id": "C3547936", "aliases": ["protein maturation by peptide bond cleavage in phagosome", "protein processing in phagosome", "protein maturation by peptide bond cleavage in phagocytic vesicle", "protein maturation by peptide bond hydrolysis in phagocytic vesicle", "protein maturation by peptide bond hydrolysis in phagosome"], "types": ["T044"], "canonical_name": "protein processing in phagocytic vesicle", "definition": "Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation. [GOC:rjd, GOC:TermGenie]"}
{"concept_id": "C3547937", "aliases": ["4-hydroxybenzeneacetate transport", "2-(4-hydroxyphenyl)ethanoate transport", "(p-hydroxyphenyl)acetate transport", "(4-hydroxyphenyl)acetate transport"], "types": ["T043"], "canonical_name": "4-hydroxyphenylacetate transport", "definition": "The directed movement of a 4-hydroxyphenylacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie, PMID:9315705]"}
{"concept_id": "C3547938", "aliases": ["(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport", "doxorubicine transport"], "types": ["T043"], "canonical_name": "doxorubicin transport", "definition": "The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie, PMID:12057006, PMID:15090538, PMID:19063901, PMID:19651502, PMID:9651400]"}
{"concept_id": "C3547939", "aliases": ["gamma-Butyrobetain transport", "4-butyrobetaine transport", "gamma-butyrobetaine transport", "4-(N-trimethylamino)butyrate transport"], "types": ["T044"], "canonical_name": "4-(trimethylammonio)butanoate transport", "definition": "The directed movement of a 4-(trimethylammonio)butanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798]"}
{"concept_id": "C3547940", "aliases": ["(-)-L-Carnitine transport", "L-Carnitine transport", "(3R)-3-hydroxy-4-(trimethylammonio)butanoate transport"], "types": ["T043"], "canonical_name": "(R)-carnitine transport", "definition": "The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798]"}
{"concept_id": "C3547941", "aliases": ["up regulation of VEGF signaling", "positive regulation of vascular endothelial growth factor signalling pathway", "positive regulation of VEGF signaling", "up-regulation of vascular endothelial growth factor signalling pathway", "upregulation of VEGF signaling", "up regulation of vascular endothelial growth factor signaling pathway", "upregulation of vascular endothelial growth factor signalling pathway", "up regulation of vascular endothelial growth factor signalling pathway", "activation of vascular endothelial growth factor signalling pathway", "positive regulation of VEGF-activated signaling pathway", "upregulation of VEGF-activated signaling pathway", "upregulation of vascular endothelial growth factor signaling pathway", "up-regulation of VEGF-activated signaling pathway", "up regulation of VEGF-activated signaling pathway", "up-regulation of vascular endothelial growth factor signaling pathway", "up-regulation of VEGF signaling"], "types": ["T044"], "canonical_name": "positive regulation of vascular endothelial growth factor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway. [GOC:TermGenie]"}
{"concept_id": "C3547942", "aliases": ["down regulation of VEGF signaling", "down regulation of vascular endothelial growth factor signalling pathway", "negative regulation of vascular endothelial growth factor signalling pathway", "down regulation of VEGF-activated signaling pathway", "down-regulation of VEGF signaling", "inhibition of vascular endothelial growth factor signalling pathway", "downregulation of vascular endothelial growth factor signaling pathway", "downregulation of VEGF-activated signaling pathway", "inhibition of VEGF signaling", "negative regulation of VEGF-activated signaling pathway", "down-regulation of vascular endothelial growth factor signalling pathway", "down regulation of vascular endothelial growth factor signaling pathway", "downregulation of VEGF signaling", "downregulation of vascular endothelial growth factor signalling pathway", "inhibition of VEGF-activated signaling pathway", "negative regulation of VEGF signaling", "down-regulation of VEGF-activated signaling pathway", "inhibition of vascular endothelial growth factor signaling pathway", "down-regulation of vascular endothelial growth factor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of vascular endothelial growth factor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway. [GOC:TermGenie]"}
{"concept_id": "C3547943", "aliases": ["regulation of VEGF signaling", "regulation of vascular endothelial growth factor signalling pathway", "regulation of VEGF-activated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of vascular endothelial growth factor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor signaling pathway. [GOC:TermGenie]"}
{"concept_id": "C3547944", "aliases": ["upregulation of p38 MAPK cascade", "activation of p38 MAPK cascade", "up-regulation of p38 cascade", "up regulation of p38 cascade", "upregulation of p38 cascade", "up regulation of p38 MAPK cascade", "up-regulation of p38MAPK cascade", "up regulation of p38MAPK cascade", "up-regulation of p38 MAPK cascade", "positive regulation of p38 MAPK cascade", "positive regulation of p38 cascade", "upregulation of p38MAPK cascade", "activation of p38 cascade"], "types": ["T040"], "canonical_name": "positive regulation of p38MAPK cascade", "definition": "Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. [GOC:TermGenie]"}
{"concept_id": "C3547945", "aliases": ["regulation of p38 cascade", "regulation of p38 MAPK cascade"], "types": ["T040"], "canonical_name": "regulation of p38MAPK cascade", "definition": "Any process that modulates the frequency, rate or extent of p38MAPK cascade. [GOC:TermGenie]"}
{"concept_id": "C3547946", "aliases": ["up-regulation of filamentous growth of a population of unicellular organisms in response to pH", "upregulation of filamentous growth of a population of unicellular organisms in response to pH", "up regulation of filamentous growth of a population of unicellular organisms in response to pH"], "types": ["T040"], "canonical_name": "positive regulation of filamentous growth of a population of unicellular organisms in response to pH", "definition": "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547947", "aliases": ["downregulation of filamentous growth of a population of unicellular organisms in response to pH", "down-regulation of filamentous growth of a population of unicellular organisms in response to pH", "down regulation of filamentous growth of a population of unicellular organisms in response to pH"], "types": ["T040"], "canonical_name": "negative regulation of filamentous growth of a population of unicellular organisms in response to pH", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547948", "aliases": [], "types": ["T039"], "canonical_name": "regulation of filamentous growth of a population of unicellular organisms in response to pH", "definition": "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547949", "aliases": ["up regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "up-regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "upregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. [GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3547950", "aliases": [], "types": ["T039"], "canonical_name": "regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. [GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3547951", "aliases": ["upregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "up-regulation of PLC-activating GPCR signaling pathway", "up-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "upregulation of PLC-activating GPCR signaling pathway", "up regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway", "positive regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "positive regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "up-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "up-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "positive regulation of PLC-activating GPCR signaling pathway", "positive regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "up regulation of phospholipase C-activating G-protein coupled receptor signaling pathway", "positive regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "up regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "up regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "upregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "upregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "up-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "up regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "upregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "activation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "up regulation of PLC-activating GPCR signaling pathway", "activation of PLC-activating GPCR signaling pathway", "up-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway", "activation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "activation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "positive regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "up regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "up-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "upregulation of phospholipase C-activating G-protein coupled receptor signaling pathway", "upregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "activation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "activation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)"], "types": ["T043"], "canonical_name": "positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547952", "aliases": ["down regulation of PLC-activating GPCR signaling pathway", "downregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "downregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "down-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway", "negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway", "down-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "downregulation of phospholipase C-activating G-protein coupled receptor signaling pathway", "down-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "down regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "down-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "negative regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "inhibition of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "inhibition of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "negative regulation of PLC-activating GPCR signaling pathway", "down regulation of phospholipase C-activating G-protein coupled receptor signaling pathway", "down-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "inhibition of PLC-activating GPCR signaling pathway", "downregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "negative regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "down regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "inhibition of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "negative regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "downregulation of PLC-activating GPCR signaling pathway", "down-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "negative regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "inhibition of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "inhibition of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "down regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "down-regulation of PLC-activating GPCR signaling pathway", "down regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "downregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "downregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "negative regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "down regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)"], "types": ["T043"], "canonical_name": "negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547953", "aliases": ["regulation of phospholipase C-activating G-protein coupled receptor signaling pathway", "regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger", "regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)", "regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)", "regulation of PLC-activating GPCR signaling pathway", "regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)"], "types": ["T043"], "canonical_name": "regulation of phospholipase C-activating G protein-coupled receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3547954", "aliases": ["upregulation of flocculation via cell wall protein-carbohydrate interaction", "up regulation of flocculation via cell wall protein-carbohydrate interaction", "up-regulation of flocculation via cell wall protein-carbohydrate interaction", "upregulation of flocculation", "up regulation of flocculation", "up-regulation of flocculation"], "types": ["T038"], "canonical_name": "positive regulation of flocculation", "definition": "Any process that activates or increases the frequency, rate or extent of flocculation. [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252]"}
{"concept_id": "C3547955", "aliases": ["negative regulation of polyketide synthesis", "down-regulation of polyketide formation", "down-regulation of polyketide biosynthetic process", "negative regulation of polyketide biosynthesis", "down-regulation of polyketide biosynthesis", "down-regulation of polyketide anabolism", "downregulation of polyketide formation", "downregulation of polyketide anabolism", "downregulation of polyketide synthesis", "down regulation of polyketide formation", "inhibition of polyketide anabolism", "down regulation of polyketide biosynthetic process", "downregulation of polyketide biosynthetic process", "down regulation of polyketide biosynthesis", "inhibition of polyketide formation", "inhibition of polyketide biosynthesis", "negative regulation of polyketide formation", "down regulation of polyketide synthesis", "negative regulation of polyketide anabolism", "downregulation of polyketide biosynthesis", "inhibition of polyketide synthesis", "down-regulation of polyketide synthesis", "down regulation of polyketide anabolism"], "types": ["T044"], "canonical_name": "negative regulation of polyketide biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of polyketide biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547956", "aliases": ["regulation of polyketide synthesis", "regulation of polyketide biosynthesis", "regulation of polyketide anabolism", "regulation of polyketide formation"], "types": ["T044"], "canonical_name": "regulation of polyketide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of polyketide biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547957", "aliases": ["upregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway", "up regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway. [GOC:sjw, GOC:TermGenie, PMID:17157995]"}
{"concept_id": "C3547958", "aliases": ["down-regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway", "downregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway", "down regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway. [GOC:sjw, GOC:TermGenie, PMID:17157995]"}
{"concept_id": "C3547959", "aliases": [], "types": ["T043"], "canonical_name": "regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway. [GOC:sjw, GOC:TermGenie, PMID:17157995]"}
{"concept_id": "C3547960", "aliases": [], "types": ["T043"], "canonical_name": "cardiac neural crest cell delamination involved in outflow tract morphogenesis", "definition": "Any cardiac neural crest cell delamination that is involved in outflow tract morphogenesis. [GOC:hjd, GOC:TermGenie, PMID:18539270]"}
{"concept_id": "C3547961", "aliases": ["osmoregulated periplasmic glucan synthesis", "osmoregulated periplasmic glucan formation", "osmoregulated periplasmic glucan anabolism", "osmoregulated periplasmic glucan biosynthesis"], "types": ["T044"], "canonical_name": "osmoregulated periplasmic glucan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547962", "aliases": ["osmoregulated periplasmic glucan catabolism", "osmoregulated periplasmic glucan breakdown", "osmoregulated periplasmic glucan degradation"], "types": ["T044"], "canonical_name": "osmoregulated periplasmic glucan catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of osmoregulated periplasmic glucan. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547963", "aliases": ["osmoregulated periplasmic glucan metabolism"], "types": ["T044"], "canonical_name": "osmoregulated periplasmic glucan metabolic process", "definition": "The chemical reactions and pathways involving osmoregulated periplasmic glucan. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C3547964", "aliases": ["activation of protein amino acid adenylylation", "up-regulation of protein adenylylation", "up regulation of protein adenylylation", "up-regulation of protein adenylation", "upregulation of protein amino acid adenylylation", "up regulation of protein AMPylation", "positive regulation of protein amino acid adenylylation", "upregulation of protein AMPylation", "positive regulation of protein AMPylation", "activation of protein adenylation", "positive regulation of protein adenylation", "up-regulation of protein AMPylation", "activation of protein AMPylation", "up regulation of protein adenylation", "up regulation of protein amino acid adenylylation", "up-regulation of protein amino acid adenylylation", "upregulation of protein adenylylation", "upregulation of protein adenylation"], "types": ["T044"], "canonical_name": "positive regulation of protein adenylylation", "definition": "Any process that activates or increases the frequency, rate or extent of protein adenylylation. [GOC:TermGenie]"}
{"concept_id": "C3547965", "aliases": ["negative regulation of protein adenylation", "down-regulation of protein AMPylation", "downregulation of protein adenylylation", "down regulation of protein adenylation", "inhibition of protein AMPylation", "downregulation of protein AMPylation", "down-regulation of protein amino acid adenylylation", "negative regulation of protein amino acid adenylylation", "down-regulation of protein adenylation", "down-regulation of protein adenylylation", "negative regulation of protein AMPylation", "down regulation of protein amino acid adenylylation", "down regulation of protein adenylylation", "downregulation of protein adenylation", "inhibition of protein amino acid adenylylation", "downregulation of protein amino acid adenylylation", "inhibition of protein adenylation", "down regulation of protein AMPylation"], "types": ["T044"], "canonical_name": "negative regulation of protein adenylylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation. [GOC:TermGenie]"}
{"concept_id": "C3547966", "aliases": ["regulation of protein adenylation", "regulation of protein AMPylation", "regulation of protein amino acid adenylylation"], "types": ["T044"], "canonical_name": "regulation of protein adenylylation", "definition": "Any process that modulates the frequency, rate or extent of protein adenylylation. [GOC:TermGenie]"}
{"concept_id": "C3547967", "aliases": ["upregulation of smooth muscle relaxation of the uterus", "up-regulation of smooth muscle relaxation of the uterus", "up regulation of smooth muscle relaxation of the uterus", "up-regulation of uterine smooth muscle relaxation", "activation of smooth muscle relaxation of the uterus", "positive regulation of smooth muscle relaxation of the uterus", "upregulation of uterine smooth muscle relaxation", "up regulation of uterine smooth muscle relaxation"], "types": ["T039"], "canonical_name": "positive regulation of uterine smooth muscle relaxation", "definition": "Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation. [GOC:TermGenie]"}
{"concept_id": "C3547968", "aliases": ["inhibition of smooth muscle relaxation of the uterus", "downregulation of smooth muscle relaxation of the uterus", "down-regulation of uterine smooth muscle relaxation", "down-regulation of smooth muscle relaxation of the uterus", "down regulation of uterine smooth muscle relaxation", "downregulation of uterine smooth muscle relaxation", "negative regulation of smooth muscle relaxation of the uterus", "down regulation of smooth muscle relaxation of the uterus"], "types": ["T039"], "canonical_name": "negative regulation of uterine smooth muscle relaxation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of uterine smooth muscle relaxation. [GOC:TermGenie]"}
{"concept_id": "C3547969", "aliases": ["regulation of smooth muscle relaxation of the uterus"], "types": ["T042"], "canonical_name": "regulation of uterine smooth muscle relaxation", "definition": "Any process that modulates the frequency, rate or extent of uterine smooth muscle relaxation. [GOC:TermGenie]"}
{"concept_id": "C3547970", "aliases": ["down regulation of violaceol II biosynthetic process", "downregulation of violaceol II synthesis", "down regulation of violaceol II synthesis", "down regulation of violaceol II anabolism", "negative regulation of violaceol II synthesis", "down-regulation of violaceol II biosynthesis", "down-regulation of violaceol II formation", "negative regulation of violaceol II biosynthesis", "inhibition of violaceol II formation", "negative regulation of violaceol II formation", "inhibition of violaceol II anabolism", "downregulation of violaceol II biosynthesis", "down regulation of violaceol II biosynthesis", "negative regulation of violaceol II anabolism", "down-regulation of violaceol II synthesis", "downregulation of violaceol II formation", "down-regulation of violaceol II anabolism", "downregulation of violaceol II anabolism", "inhibition of violaceol II synthesis", "downregulation of violaceol II biosynthetic process", "down-regulation of violaceol II biosynthetic process", "down regulation of violaceol II formation", "inhibition of violaceol II biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of violaceol II biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol II biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547971", "aliases": ["regulation of violaceol II synthesis", "regulation of violaceol II biosynthesis", "regulation of violaceol II formation", "regulation of violaceol II anabolism"], "types": ["T044"], "canonical_name": "regulation of violaceol II biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of violaceol II biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547972", "aliases": ["downregulation of violaceol I synthesis", "down-regulation of violaceol I anabolism", "inhibition of violaceol I biosynthesis", "negative regulation of violaceol I anabolism", "down regulation of violaceol I anabolism", "down-regulation of violaceol I biosynthesis", "down-regulation of violaceol I biosynthetic process", "negative regulation of violaceol I synthesis", "downregulation of violaceol I anabolism", "down regulation of violaceol I biosynthetic process", "negative regulation of violaceol I formation", "down-regulation of violaceol I formation", "inhibition of violaceol I anabolism", "inhibition of violaceol I formation", "inhibition of violaceol I synthesis", "down regulation of violaceol I biosynthesis", "down regulation of violaceol I synthesis", "downregulation of violaceol I biosynthetic process", "downregulation of violaceol I formation", "downregulation of violaceol I biosynthesis", "negative regulation of violaceol I biosynthesis", "down-regulation of violaceol I synthesis", "down regulation of violaceol I formation"], "types": ["T044"], "canonical_name": "negative regulation of violaceol I biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol I biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547973", "aliases": ["regulation of violaceol I synthesis", "regulation of violaceol I anabolism", "regulation of violaceol I biosynthesis", "regulation of violaceol I formation"], "types": ["T044"], "canonical_name": "regulation of violaceol I biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of violaceol I biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547974", "aliases": ["downregulation of tensidol B biosynthesis", "down regulation of tensidol B biosynthetic process", "down-regulation of tensidol B biosynthesis", "inhibition of tensidol B formation", "down-regulation of tensidol B anabolism", "down regulation of tensidol B synthesis", "downregulation of tensidol B synthesis", "down regulation of tensidol B biosynthesis", "downregulation of tensidol B anabolism", "down-regulation of tensidol B biosynthetic process", "negative regulation of tensidol B biosynthesis", "negative regulation of tensidol B formation", "inhibition of tensidol B biosynthesis", "inhibition of tensidol B anabolism", "down-regulation of tensidol B synthesis", "negative regulation of tensidol B synthesis", "down regulation of tensidol B formation", "negative regulation of tensidol B anabolism", "down regulation of tensidol B anabolism", "inhibition of tensidol B synthesis", "down-regulation of tensidol B formation", "downregulation of tensidol B biosynthetic process", "downregulation of tensidol B formation"], "types": ["T044"], "canonical_name": "negative regulation of tensidol B biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol B biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547975", "aliases": ["regulation of tensidol B anabolism", "regulation of tensidol B synthesis", "regulation of tensidol B biosynthesis", "regulation of tensidol B formation"], "types": ["T044"], "canonical_name": "regulation of tensidol B biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of tensidol B biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547976", "aliases": ["inhibition of tensidol A biosynthesis", "down regulation of tensidol A synthesis", "down-regulation of tensidol A synthesis", "negative regulation of tensidol A formation", "negative regulation of tensidol A biosynthesis", "inhibition of tensidol A formation", "down regulation of tensidol A formation", "inhibition of tensidol A anabolism", "downregulation of tensidol A biosynthesis", "down regulation of tensidol A biosynthesis", "negative regulation of tensidol A anabolism", "down regulation of tensidol A anabolism", "negative regulation of tensidol A synthesis", "down regulation of tensidol A biosynthetic process", "downregulation of tensidol A biosynthetic process", "down-regulation of tensidol A biosynthesis", "downregulation of tensidol A formation", "downregulation of tensidol A synthesis", "downregulation of tensidol A anabolism", "down-regulation of tensidol A formation", "down-regulation of tensidol A anabolism", "down-regulation of tensidol A biosynthetic process", "inhibition of tensidol A synthesis"], "types": ["T044"], "canonical_name": "negative regulation of tensidol A biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547977", "aliases": ["regulation of tensidol A synthesis", "regulation of tensidol A anabolism", "regulation of tensidol A biosynthesis", "regulation of tensidol A formation"], "types": ["T044"], "canonical_name": "regulation of tensidol A biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of tensidol A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547978", "aliases": ["upregulation of siderophore synthesis", "up-regulation of siderophore synthesis", "up-regulation of siderophore formation", "activation of siderophore anabolism", "upregulation of siderophore biosynthetic process", "up regulation of siderophore biosynthetic process", "activation of siderophore biosynthesis", "up regulation of siderophore synthesis", "up-regulation of siderophore biosynthetic process", "positive regulation of siderophore formation", "upregulation of siderophore biosynthesis", "up regulation of siderophore biosynthesis", "upregulation of siderophore formation", "activation of siderophore formation", "upregulation of siderophore anabolism", "positive regulation of siderophore anabolism", "positive regulation of siderophore synthesis", "up regulation of siderophore anabolism", "up regulation of siderophore formation", "up-regulation of siderophore anabolism", "activation of siderophore synthesis", "positive regulation of siderophore biosynthesis", "up-regulation of siderophore biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of siderophore biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of siderophore biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547979", "aliases": ["downregulation of siderophore biosynthesis", "down regulation of siderophore anabolism", "down regulation of siderophore formation", "downregulation of siderophore formation", "down-regulation of siderophore biosynthetic process", "down regulation of siderophore biosynthesis", "down-regulation of siderophore anabolism", "inhibition of siderophore synthesis", "negative regulation of siderophore anabolism", "inhibition of siderophore biosynthesis", "negative regulation of siderophore synthesis", "downregulation of siderophore anabolism", "down-regulation of siderophore formation", "down regulation of siderophore biosynthetic process", "inhibition of siderophore anabolism", "downregulation of siderophore biosynthetic process", "down-regulation of siderophore synthesis", "down regulation of siderophore synthesis", "inhibition of siderophore formation", "negative regulation of siderophore formation", "downregulation of siderophore synthesis", "negative regulation of siderophore biosynthesis", "down-regulation of siderophore biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of siderophore biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547980", "aliases": ["regulation of siderophore biosynthesis", "regulation of siderophore anabolism", "regulation of siderophore synthesis", "regulation of siderophore formation"], "types": ["T044"], "canonical_name": "regulation of siderophore biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of siderophore biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547981", "aliases": ["negative regulation of orcinol biosynthesis", "down-regulation of orcinol biosynthesis", "downregulation of orcinol biosynthesis", "inhibition of orcinol anabolism", "inhibition of orcinol formation", "down-regulation of orcinol formation", "down regulation of orcinol biosynthesis", "down regulation of orcinol anabolism", "inhibition of orcinol synthesis", "downregulation of orcinol anabolism", "down-regulation of orcinol biosynthetic process", "negative regulation of orcinol anabolism", "downregulation of orcinol formation", "downregulation of orcinol synthesis", "down regulation of orcinol biosynthetic process", "downregulation of orcinol biosynthetic process", "inhibition of orcinol biosynthesis", "negative regulation of orcinol formation", "down regulation of orcinol formation", "down regulation of orcinol synthesis", "negative regulation of orcinol synthesis", "down-regulation of orcinol anabolism", "down-regulation of orcinol synthesis"], "types": ["T044"], "canonical_name": "negative regulation of orcinol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of orcinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547982", "aliases": ["regulation of orcinol formation", "regulation of orcinol synthesis", "regulation of orcinol biosynthesis", "regulation of orcinol anabolism"], "types": ["T044"], "canonical_name": "regulation of orcinol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of orcinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547983", "aliases": ["down regulation of o-orsellinic acid biosynthesis", "down regulation of o-orsellinic acid synthesis", "downregulation of o-orsellinic acid biosynthetic process", "down-regulation of o-orsellinic acid anabolism", "down regulation of o-orsellinic acid anabolism", "downregulation of o-orsellinic acid formation", "inhibition of o-orsellinic acid synthesis", "inhibition of o-orsellinic acid biosynthesis", "downregulation of o-orsellinic acid biosynthesis", "inhibition of o-orsellinic acid anabolism", "downregulation of o-orsellinic acid anabolism", "down-regulation of o-orsellinic acid biosynthesis", "down-regulation of o-orsellinic acid synthesis", "negative regulation of o-orsellinic acid anabolism", "downregulation of o-orsellinic acid synthesis", "negative regulation of o-orsellinic acid synthesis", "down-regulation of o-orsellinic acid biosynthetic process", "negative regulation of o-orsellinic acid biosynthesis", "down-regulation of o-orsellinic acid formation", "down regulation of o-orsellinic acid formation", "inhibition of o-orsellinic acid formation", "negative regulation of o-orsellinic acid formation", "down regulation of o-orsellinic acid biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of o-orsellinic acid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of o-orsellinic acid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547984", "aliases": ["regulation of o-orsellinic acid anabolism", "regulation of o-orsellinic acid synthesis", "regulation of o-orsellinic acid formation", "regulation of o-orsellinic acid biosynthesis"], "types": ["T040"], "canonical_name": "regulation of o-orsellinic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of o-orsellinic acid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547985", "aliases": ["positive regulation of N',N'',N'''-triacetylfusarinine C synthesis", "activation of N',N'',N'''-triacetylfusarinine C formation", "up regulation of N',N'',N'''-triacetylfusarinine C formation", "up regulation of N',N'',N'''-triacetylfusarinine C biosynthesis", "upregulation of N',N'',N'''-triacetylfusarinine C anabolism", "upregulation of N',N'',N'''-triacetylfusarinine C biosynthesis", "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process", "positive regulation of N',N'',N'''-triacetylfusarinine C biosynthesis", "up regulation of N',N'',N'''-triacetylfusarinine C anabolism", "up regulation of N',N'',N'''-triacetylfusarinine C synthesis", "up regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process", "positive regulation of N',N'',N'''-triacetylfusarinine C anabolism", "positive regulation of N',N'',N'''-triacetylfusarinine C formation", "activation of N',N'',N'''-triacetylfusarinine C synthesis", "upregulation of N',N'',N'''-triacetylfusarinine C formation", "upregulation of N',N'',N'''-triacetylfusarinine C synthesis", "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis", "activation of N',N'',N'''-triacetylfusarinine C biosynthesis", "up-regulation of N',N'',N'''-triacetylfusarinine C anabolism", "activation of N',N'',N'''-triacetylfusarinine C anabolism", "upregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process", "up-regulation of N',N'',N'''-triacetylfusarinine C formation", "up-regulation of N',N'',N'''-triacetylfusarinine C synthesis"], "types": ["T044"], "canonical_name": "positive regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547986", "aliases": ["down-regulation of N',N'',N'''-triacetylfusarinine C anabolism", "downregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process", "downregulation of N',N'',N'''-triacetylfusarinine C biosynthesis", "down-regulation of N',N'',N'''-triacetylfusarinine C formation", "negative regulation of N',N'',N'''-triacetylfusarinine C biosynthesis", "down-regulation of N',N'',N'''-triacetylfusarinine C synthesis", "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process", "down regulation of N',N'',N'''-triacetylfusarinine C biosynthesis", "downregulation of N',N'',N'''-triacetylfusarinine C synthesis", "downregulation of N',N'',N'''-triacetylfusarinine C formation", "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis", "negative regulation of N',N'',N'''-triacetylfusarinine C anabolism", "inhibition of N',N'',N'''-triacetylfusarinine C synthesis", "down regulation of N',N'',N'''-triacetylfusarinine C anabolism", "downregulation of N',N'',N'''-triacetylfusarinine C anabolism", "negative regulation of N',N'',N'''-triacetylfusarinine C formation", "down regulation of N',N'',N'''-triacetylfusarinine C formation", "inhibition of N',N'',N'''-triacetylfusarinine C formation", "inhibition of N',N'',N'''-triacetylfusarinine C biosynthesis", "negative regulation of N',N'',N'''-triacetylfusarinine C synthesis", "down regulation of N',N'',N'''-triacetylfusarinine C synthesis", "down regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process", "inhibition of N',N'',N'''-triacetylfusarinine C anabolism"], "types": ["T044"], "canonical_name": "negative regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547987", "aliases": ["regulation of N',N'',N'''-triacetylfusarinine C biosynthesis", "regulation of N',N'',N'''-triacetylfusarinine C synthesis", "regulation of N',N'',N'''-triacetylfusarinine C anabolism", "regulation of N',N'',N'''-triacetylfusarinine C formation"], "types": ["T044"], "canonical_name": "regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547988", "aliases": ["negative regulation of (+)-kotanin anabolism", "downregulation of (+)-kotanin synthesis", "down regulation of (+)-kotanin formation", "down regulation of (+)-kotanin biosynthesis", "negative regulation of (+)-kotanin synthesis", "down-regulation of (+)-kotanin synthesis", "negative regulation of (+)-kotanin biosynthesis", "down-regulation of (+)-kotanin formation", "downregulation of (+)-kotanin anabolism", "down regulation of (+)-kotanin synthesis", "down regulation of (+)-kotanin biosynthetic process", "down-regulation of (+)-kotanin biosynthetic process", "inhibition of (+)-kotanin biosynthesis", "down-regulation of (+)-kotanin biosynthesis", "downregulation of (+)-kotanin biosynthetic process", "negative regulation of (+)-kotanin formation", "inhibition of (+)-kotanin formation", "down-regulation of (+)-kotanin anabolism", "inhibition of (+)-kotanin synthesis", "inhibition of (+)-kotanin anabolism", "downregulation of (+)-kotanin formation", "down regulation of (+)-kotanin anabolism", "downregulation of (+)-kotanin biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of (+)-kotanin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of (+)-kotanin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547989", "aliases": ["regulation of (+)-kotanin formation", "regulation of (+)-kotanin anabolism", "regulation of (+)-kotanin synthesis", "regulation of (+)-kotanin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of (+)-kotanin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of (+)-kotanin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547990", "aliases": ["down-regulation of gliotoxin biosynthesis", "downregulation of gliotoxin synthesis", "down regulation of gliotoxin synthesis", "downregulation of gliotoxin formation", "inhibition of gliotoxin synthesis", "negative regulation of gliotoxin formation", "down-regulation of gliotoxin formation", "down-regulation of gliotoxin synthesis", "negative regulation of gliotoxin anabolism", "down-regulation of gliotoxin anabolism", "inhibition of gliotoxin biosynthesis", "negative regulation of gliotoxin synthesis", "down regulation of gliotoxin formation", "inhibition of gliotoxin anabolism", "down regulation of gliotoxin biosynthetic process", "downregulation of gliotoxin anabolism", "downregulation of gliotoxin biosynthetic process", "downregulation of gliotoxin biosynthesis", "down-regulation of gliotoxin biosynthetic process", "negative regulation of gliotoxin biosynthesis", "down regulation of gliotoxin anabolism", "inhibition of gliotoxin formation", "down regulation of gliotoxin biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of gliotoxin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gliotoxin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547991", "aliases": ["regulation of gliotoxin synthesis", "regulation of gliotoxin formation", "regulation of gliotoxin anabolism", "regulation of gliotoxin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of gliotoxin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547992", "aliases": ["negative regulation of gerfelin synthesis", "down-regulation of gerfelin formation", "down regulation of gerfelin biosynthetic process", "down-regulation of gerfelin synthesis", "down regulation of gerfelin biosynthesis", "downregulation of gerfelin biosynthetic process", "inhibition of gerfelin anabolism", "down-regulation of gerfelin biosynthetic process", "downregulation of gerfelin anabolism", "down regulation of gerfelin formation", "inhibition of gerfelin synthesis", "negative regulation of gerfelin formation", "down regulation of gerfelin synthesis", "downregulation of gerfelin synthesis", "negative regulation of gerfelin biosynthesis", "downregulation of gerfelin formation", "negative regulation of gerfelin anabolism", "downregulation of gerfelin biosynthesis", "inhibition of gerfelin biosynthesis", "down-regulation of gerfelin anabolism", "inhibition of gerfelin formation", "down-regulation of gerfelin biosynthesis", "down regulation of gerfelin anabolism"], "types": ["T044"], "canonical_name": "negative regulation of gerfelin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gerfelin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547993", "aliases": ["regulation of gerfelin synthesis", "regulation of gerfelin biosynthesis", "regulation of gerfelin formation", "regulation of gerfelin anabolism"], "types": ["T040"], "canonical_name": "regulation of gerfelin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of gerfelin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547994", "aliases": ["inhibition of fumonisin synthesis", "down regulation of fumonisin biosynthesis", "down-regulation of fumonisin biosynthetic process", "downregulation of fumonisin biosynthetic process", "downregulation of fumonisin anabolism", "negative regulation of fumonisin synthesis", "down-regulation of fumonisin biosynthesis", "down-regulation of fumonisin formation", "downregulation of fumonisin biosynthesis", "downregulation of fumonisin formation", "down regulation of fumonisin anabolism", "negative regulation of fumonisin biosynthesis", "inhibition of fumonisin formation", "inhibition of fumonisin anabolism", "down regulation of fumonisin synthesis", "downregulation of fumonisin synthesis", "negative regulation of fumonisin anabolism", "down-regulation of fumonisin synthesis", "down regulation of fumonisin formation", "inhibition of fumonisin biosynthesis", "down regulation of fumonisin biosynthetic process", "negative regulation of fumonisin formation", "down-regulation of fumonisin anabolism"], "types": ["T044"], "canonical_name": "negative regulation of fumonisin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fumonisin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547995", "aliases": ["regulation of fumonisin biosynthesis", "regulation of fumonisin formation", "regulation of fumonisin synthesis", "regulation of fumonisin anabolism"], "types": ["T040"], "canonical_name": "regulation of fumonisin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of fumonisin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547996", "aliases": ["1-octadecene biosynthetic process", "octadecene synthesis", "octadecene formation", "octadecene anabolism", "octadecene biosynthesis"], "types": ["T044"], "canonical_name": "octadecene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of octadecene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547997", "aliases": ["octadecene metabolism"], "types": ["T043"], "canonical_name": "octadecene metabolic process", "definition": "The chemical reactions and pathways involving octadecene. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3547998", "aliases": ["upregulation of ferricrocin biosynthesis", "activation of ferricrocin formation", "positive regulation of ferricrocin formation", "activation of ferricrocin anabolism", "up-regulation of ferricrocin biosynthetic process", "activation of ferricrocin biosynthesis", "up-regulation of ferricrocin biosynthesis", "positive regulation of ferricrocin synthesis", "up regulation of ferricrocin formation", "upregulation of ferricrocin biosynthetic process", "up regulation of ferricrocin biosynthesis", "upregulation of ferricrocin formation", "upregulation of ferricrocin anabolism", "up regulation of ferricrocin biosynthetic process", "positive regulation of ferricrocin anabolism", "up regulation of ferricrocin synthesis", "up-regulation of ferricrocin synthesis", "activation of ferricrocin synthesis", "up regulation of ferricrocin anabolism", "positive regulation of ferricrocin biosynthesis", "upregulation of ferricrocin synthesis", "up-regulation of ferricrocin anabolism", "up-regulation of ferricrocin formation"], "types": ["T044"], "canonical_name": "positive regulation of ferricrocin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of ferricrocin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3547999", "aliases": ["negative regulation of ferricrocin synthesis", "down-regulation of ferricrocin biosynthetic process", "down regulation of ferricrocin anabolism", "down-regulation of ferricrocin anabolism", "down regulation of ferricrocin biosynthesis", "inhibition of ferricrocin biosynthesis", "down regulation of ferricrocin synthesis", "inhibition of ferricrocin formation", "down-regulation of ferricrocin biosynthesis", "down-regulation of ferricrocin synthesis", "negative regulation of ferricrocin formation", "inhibition of ferricrocin anabolism", "downregulation of ferricrocin biosynthesis", "negative regulation of ferricrocin biosynthesis", "downregulation of ferricrocin synthesis", "downregulation of ferricrocin formation", "negative regulation of ferricrocin anabolism", "downregulation of ferricrocin biosynthetic process", "down-regulation of ferricrocin formation", "down regulation of ferricrocin biosynthetic process", "down regulation of ferricrocin formation", "downregulation of ferricrocin anabolism", "inhibition of ferricrocin synthesis"], "types": ["T044"], "canonical_name": "negative regulation of ferricrocin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ferricrocin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548000", "aliases": ["regulation of ferricrocin formation", "regulation of ferricrocin anabolism", "regulation of ferricrocin synthesis", "regulation of ferricrocin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of ferricrocin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of ferricrocin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548001", "aliases": ["up regulation of F-9775B biosynthesis", "positive regulation of F-9775B formation", "up regulation of F-9775B formation", "up regulation of F-9775B biosynthetic process", "upregulation of F-9775B biosynthetic process", "positive regulation of F-9775B biosynthesis", "positive regulation of F-9775B synthesis", "up-regulation of F-9775B anabolism", "activation of F-9775B formation", "positive regulation of F-9775B anabolism", "upregulation of F-9775B biosynthesis", "upregulation of F-9775B formation", "up-regulation of F-9775B formation", "activation of F-9775B synthesis", "upregulation of F-9775B anabolism", "up regulation of F-9775B synthesis", "up regulation of F-9775B anabolism", "up-regulation of F-9775B biosynthesis", "up-regulation of F-9775B synthesis", "activation of F-9775B biosynthesis", "up-regulation of F-9775B biosynthetic process", "activation of F-9775B anabolism", "upregulation of F-9775B synthesis"], "types": ["T044"], "canonical_name": "positive regulation of F-9775B biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of F-9775B biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548002", "aliases": ["downregulation of F-9775B synthesis", "negative regulation of F-9775B biosynthesis", "down regulation of F-9775B biosynthetic process", "down regulation of F-9775B anabolism", "inhibition of F-9775B biosynthesis", "inhibition of F-9775B anabolism", "negative regulation of F-9775B anabolism", "down regulation of F-9775B biosynthesis", "downregulation of F-9775B anabolism", "inhibition of F-9775B synthesis", "down-regulation of F-9775B formation", "down-regulation of F-9775B biosynthetic process", "down-regulation of F-9775B synthesis", "down regulation of F-9775B synthesis", "negative regulation of F-9775B formation", "down-regulation of F-9775B anabolism", "downregulation of F-9775B biosynthesis", "down-regulation of F-9775B biosynthesis", "negative regulation of F-9775B synthesis", "down regulation of F-9775B formation", "inhibition of F-9775B formation", "downregulation of F-9775B biosynthetic process", "downregulation of F-9775B formation"], "types": ["T044"], "canonical_name": "negative regulation of F-9775B biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775B biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548003", "aliases": ["regulation of F-9775B biosynthesis", "regulation of F-9775B synthesis", "regulation of F-9775B formation", "regulation of F-9775B anabolism"], "types": ["T044"], "canonical_name": "regulation of F-9775B biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of F-9775B biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548004", "aliases": ["olefin biosynthesis", "olefin anabolism", "olefin synthesis", "olefin formation"], "types": ["T044"], "canonical_name": "olefin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of olefin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548005", "aliases": ["olefin metabolism"], "types": ["T040"], "canonical_name": "olefin metabolic process", "definition": "The chemical reactions and pathways involving olefin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548006", "aliases": ["upregulation of F-9775A biosynthesis", "positive regulation of F-9775A biosynthesis", "positive regulation of F-9775A formation", "upregulation of F-9775A biosynthetic process", "positive regulation of F-9775A anabolism", "upregulation of F-9775A formation", "up regulation of F-9775A anabolism", "activation of F-9775A anabolism", "up-regulation of F-9775A biosynthetic process", "upregulation of F-9775A synthesis", "up-regulation of F-9775A synthesis", "up-regulation of F-9775A biosynthesis", "upregulation of F-9775A anabolism", "positive regulation of F-9775A synthesis", "activation of F-9775A biosynthesis", "up-regulation of F-9775A formation", "up regulation of F-9775A biosynthesis", "activation of F-9775A formation", "activation of F-9775A synthesis", "up regulation of F-9775A biosynthetic process", "up regulation of F-9775A formation", "up regulation of F-9775A synthesis", "up-regulation of F-9775A anabolism"], "types": ["T044"], "canonical_name": "positive regulation of F-9775A biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of F-9775A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548007", "aliases": ["down regulation of F-9775A biosynthetic process", "downregulation of F-9775A anabolism", "inhibition of F-9775A anabolism", "down-regulation of F-9775A synthesis", "inhibition of F-9775A formation", "downregulation of F-9775A biosynthesis", "down regulation of F-9775A synthesis", "down regulation of F-9775A anabolism", "down regulation of F-9775A biosynthesis", "down-regulation of F-9775A biosynthetic process", "down-regulation of F-9775A formation", "negative regulation of F-9775A anabolism", "negative regulation of F-9775A synthesis", "down regulation of F-9775A formation", "negative regulation of F-9775A formation", "down-regulation of F-9775A biosynthesis", "downregulation of F-9775A formation", "inhibition of F-9775A biosynthesis", "downregulation of F-9775A synthesis", "negative regulation of F-9775A biosynthesis", "downregulation of F-9775A biosynthetic process", "down-regulation of F-9775A anabolism", "inhibition of F-9775A synthesis"], "types": ["T044"], "canonical_name": "negative regulation of F-9775A biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548008", "aliases": ["regulation of F-9775A formation", "regulation of F-9775A synthesis", "regulation of F-9775A anabolism", "regulation of F-9775A biosynthesis"], "types": ["T044"], "canonical_name": "regulation of F-9775A biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of F-9775A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548009", "aliases": ["negative regulation of endocrocin synthesis", "down regulation of endocrocin biosynthetic process", "inhibition of endocrocin biosynthesis", "down-regulation of endocrocin biosynthetic process", "negative regulation of endocrocin anabolism", "negative regulation of endocrocin formation", "downregulation of endocrocin biosynthesis", "down regulation of endocrocin anabolism", "inhibition of endocrocin anabolism", "down-regulation of endocrocin biosynthesis", "inhibition of endocrocin synthesis", "down regulation of endocrocin synthesis", "negative regulation of endocrocin biosynthesis", "down-regulation of endocrocin formation", "inhibition of endocrocin formation", "down regulation of endocrocin formation", "down-regulation of endocrocin synthesis", "down-regulation of endocrocin anabolism", "downregulation of endocrocin formation", "downregulation of endocrocin anabolism", "downregulation of endocrocin synthesis", "down regulation of endocrocin biosynthesis", "downregulation of endocrocin biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of endocrocin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endocrocin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548010", "aliases": ["regulation of endocrocin formation", "regulation of endocrocin synthesis", "regulation of endocrocin biosynthesis", "regulation of endocrocin anabolism"], "types": ["T044"], "canonical_name": "regulation of endocrocin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of endocrocin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548011", "aliases": ["regulation of emodin biosynthesis", "regulation of emodin anabolism", "regulation of emodin formation", "regulation of emodin synthesis"], "types": ["T044"], "canonical_name": "regulation of emodin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of emodin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548012", "aliases": ["up regulation of emericellamide A synthesis", "up-regulation of emericellamide A anabolism", "upregulation of emericellamide A biosynthesis", "upregulation of emericellamide A formation", "up regulation of emericellamide A formation", "up-regulation of emericellamide A formation", "up regulation of emericellamide A anabolism", "up regulation of emericellamide A biosynthetic process", "activation of emericellamide A biosynthesis", "positive regulation of emericellamide A formation", "positive regulation of emericellamide A biosynthesis", "activation of emericellamide A anabolism", "up-regulation of emericellamide A synthesis", "up-regulation of emericellamide A biosynthetic process", "upregulation of emericellamide A synthesis", "activation of emericellamide A formation", "activation of emericellamide A synthesis", "upregulation of emericellamide A anabolism", "positive regulation of emericellamide A synthesis", "positive regulation of emericellamide A anabolism", "up-regulation of emericellamide A biosynthesis", "upregulation of emericellamide A biosynthetic process", "up regulation of emericellamide A biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of emericellamide A biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of emericellamide A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548013", "aliases": ["down regulation of emericellamide A biosynthetic process", "down-regulation of emericellamide A formation", "down regulation of emericellamide A formation", "inhibition of emericellamide A anabolism", "inhibition of emericellamide A synthesis", "down-regulation of emericellamide A biosynthetic process", "downregulation of emericellamide A biosynthesis", "down-regulation of emericellamide A anabolism", "negative regulation of emericellamide A formation", "downregulation of emericellamide A formation", "negative regulation of emericellamide A anabolism", "downregulation of emericellamide A biosynthetic process", "down regulation of emericellamide A synthesis", "down regulation of emericellamide A biosynthesis", "downregulation of emericellamide A anabolism", "down-regulation of emericellamide A synthesis", "down regulation of emericellamide A anabolism", "inhibition of emericellamide A biosynthesis", "negative regulation of emericellamide A biosynthesis", "down-regulation of emericellamide A biosynthesis", "negative regulation of emericellamide A synthesis", "inhibition of emericellamide A formation", "downregulation of emericellamide A synthesis"], "types": ["T044"], "canonical_name": "negative regulation of emericellamide A biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548014", "aliases": ["regulation of emericellamide A anabolism", "regulation of emericellamide A biosynthesis", "regulation of emericellamide A formation", "regulation of emericellamide A synthesis"], "types": ["T044"], "canonical_name": "regulation of emericellamide A biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of emericellamide A biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548015", "aliases": ["negative regulation of emericellamide synthesis", "down-regulation of emericellamide biosynthesis", "negative regulation of emericellamide anabolism", "inhibition of emericellamide anabolism", "downregulation of emericellamide biosynthesis", "downregulation of emericellamide formation", "down-regulation of emericellamide formation", "inhibition of emericellamide synthesis", "down-regulation of emericellamide biosynthetic process", "down regulation of emericellamide formation", "down regulation of emericellamide anabolism", "down regulation of emericellamide biosynthesis", "down regulation of emericellamide synthesis", "downregulation of emericellamide anabolism", "downregulation of emericellamide biosynthetic process", "negative regulation of emericellamide biosynthesis", "down regulation of emericellamide biosynthetic process", "down-regulation of emericellamide anabolism", "down-regulation of emericellamide synthesis", "downregulation of emericellamide synthesis", "inhibition of emericellamide biosynthesis", "inhibition of emericellamide formation", "negative regulation of emericellamide formation"], "types": ["T040"], "canonical_name": "negative regulation of emericellamide biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548016", "aliases": ["regulation of emericellamide formation", "regulation of emericellamide synthesis", "regulation of emericellamide anabolism", "regulation of emericellamide biosynthesis"], "types": ["T044"], "canonical_name": "regulation of emericellamide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of emericellamide biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548017", "aliases": ["downregulation of diorcinol anabolism", "negative regulation of diorcinol anabolism", "downregulation of diorcinol biosynthesis", "downregulation of diorcinol biosynthetic process", "down regulation of diorcinol anabolism", "inhibition of diorcinol formation", "negative regulation of diorcinol biosynthesis", "downregulation of diorcinol synthesis", "inhibition of diorcinol biosynthesis", "down regulation of diorcinol biosynthetic process", "negative regulation of diorcinol formation", "down-regulation of diorcinol biosynthetic process", "down-regulation of diorcinol anabolism", "negative regulation of diorcinol synthesis", "inhibition of diorcinol anabolism", "downregulation of diorcinol formation", "down-regulation of diorcinol formation", "down-regulation of diorcinol synthesis", "down regulation of diorcinol biosynthesis", "down regulation of diorcinol synthesis", "down regulation of diorcinol formation", "down-regulation of diorcinol biosynthesis", "inhibition of diorcinol synthesis"], "types": ["T044"], "canonical_name": "negative regulation of diorcinol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of diorcinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548018", "aliases": ["regulation of diorcinol biosynthesis", "regulation of diorcinol formation", "regulation of diorcinol anabolism", "regulation of diorcinol synthesis"], "types": ["T044"], "canonical_name": "regulation of diorcinol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of diorcinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548019", "aliases": ["down regulation of demethylkotanin biosynthesis", "downregulation of demethylkotanin biosynthesis", "down-regulation of demethylkotanin biosynthesis", "inhibition of demethylkotanin biosynthesis", "negative regulation of demethylkotanin biosynthesis", "downregulation of demethylkotanin formation", "downregulation of demethylkotanin biosynthetic process", "inhibition of demethylkotanin formation", "inhibition of demethylkotanin anabolism", "negative regulation of demethylkotanin formation", "downregulation of demethylkotanin anabolism", "negative regulation of demethylkotanin anabolism", "down-regulation of demethylkotanin synthesis", "down regulation of demethylkotanin biosynthetic process", "downregulation of demethylkotanin synthesis", "inhibition of demethylkotanin synthesis", "down-regulation of demethylkotanin biosynthetic process", "down regulation of demethylkotanin formation", "down-regulation of demethylkotanin anabolism", "down regulation of demethylkotanin synthesis", "down-regulation of demethylkotanin formation", "down regulation of demethylkotanin anabolism", "negative regulation of demethylkotanin synthesis"], "types": ["T044"], "canonical_name": "negative regulation of demethylkotanin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of demethylkotanin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548020", "aliases": ["regulation of demethylkotanin biosynthesis", "regulation of demethylkotanin formation", "regulation of demethylkotanin anabolism", "regulation of demethylkotanin synthesis"], "types": ["T044"], "canonical_name": "regulation of demethylkotanin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of demethylkotanin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548021", "aliases": ["up-regulation of dehydroaustinol anabolism", "upregulation of dehydroaustinol synthesis", "up-regulation of dehydroaustinol formation", "activation of dehydroaustinol anabolism", "up-regulation of dehydroaustinol synthesis", "upregulation of dehydroaustinol biosynthesis", "positive regulation of dehydroaustinol synthesis", "up regulation of dehydroaustinol biosynthesis", "up regulation of dehydroaustinol formation", "upregulation of dehydroaustinol formation", "positive regulation of dehydroaustinol anabolism", "upregulation of dehydroaustinol anabolism", "positive regulation of dehydroaustinol biosynthesis", "up regulation of dehydroaustinol synthesis", "upregulation of dehydroaustinol biosynthetic process", "positive regulation of dehydroaustinol formation", "up regulation of dehydroaustinol biosynthetic process", "up-regulation of dehydroaustinol biosynthetic process", "up regulation of dehydroaustinol anabolism", "activation of dehydroaustinol synthesis", "activation of dehydroaustinol formation", "activation of dehydroaustinol biosynthesis", "up-regulation of dehydroaustinol biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of dehydroaustinol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of dehydroaustinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548022", "aliases": ["down regulation of dehydroaustinol biosynthetic process", "down-regulation of dehydroaustinol biosynthetic process", "downregulation of dehydroaustinol synthesis", "negative regulation of dehydroaustinol formation", "inhibition of dehydroaustinol biosynthesis", "downregulation of dehydroaustinol anabolism", "down regulation of dehydroaustinol synthesis", "downregulation of dehydroaustinol biosynthetic process", "down regulation of dehydroaustinol formation", "down regulation of dehydroaustinol anabolism", "down-regulation of dehydroaustinol formation", "negative regulation of dehydroaustinol biosynthesis", "down-regulation of dehydroaustinol synthesis", "inhibition of dehydroaustinol formation", "downregulation of dehydroaustinol formation", "down-regulation of dehydroaustinol anabolism", "negative regulation of dehydroaustinol anabolism", "inhibition of dehydroaustinol anabolism", "down regulation of dehydroaustinol biosynthesis", "downregulation of dehydroaustinol biosynthesis", "down-regulation of dehydroaustinol biosynthesis", "negative regulation of dehydroaustinol synthesis", "inhibition of dehydroaustinol synthesis"], "types": ["T044"], "canonical_name": "negative regulation of dehydroaustinol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroaustinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548023", "aliases": ["regulation of dehydroaustinol formation", "regulation of dehydroaustinol anabolism", "regulation of dehydroaustinol synthesis", "regulation of dehydroaustinol biosynthesis"], "types": ["T044"], "canonical_name": "regulation of dehydroaustinol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of dehydroaustinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548024", "aliases": ["activation of chanoclavine-I aldehyde synthesis", "up regulation of chanoclavine-I aldehyde anabolism", "up regulation of chanoclavine-I aldehyde synthesis", "positive regulation of chanoclavine-I aldehyde formation", "upregulation of chanoclavine-I aldehyde biosynthesis", "up-regulation of chanoclavine-I aldehyde biosynthesis", "upregulation of chanoclavine-I aldehyde synthesis", "up-regulation of chanoclavine-I aldehyde synthesis", "up regulation of chanoclavine-I aldehyde formation", "positive regulation of chanoclavine-I aldehyde anabolism", "up-regulation of chanoclavine-I aldehyde anabolism", "positive regulation of chanoclavine-I aldehyde biosynthesis", "activation of chanoclavine-I aldehyde anabolism", "upregulation of chanoclavine-I aldehyde anabolism", "positive regulation of chanoclavine-I aldehyde synthesis", "upregulation of chanoclavine-I aldehyde biosynthetic process", "up-regulation of chanoclavine-I aldehyde formation", "upregulation of chanoclavine-I aldehyde formation", "up regulation of chanoclavine-I aldehyde biosynthesis", "activation of chanoclavine-I aldehyde biosynthesis", "up regulation of chanoclavine-I aldehyde biosynthetic process", "activation of chanoclavine-I aldehyde formation", "up-regulation of chanoclavine-I aldehyde biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of chanoclavine-I aldehyde biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548025", "aliases": ["inhibition of chanoclavine-I aldehyde biosynthesis", "downregulation of chanoclavine-I aldehyde biosynthetic process", "negative regulation of chanoclavine-I aldehyde anabolism", "downregulation of chanoclavine-I aldehyde anabolism", "down-regulation of chanoclavine-I aldehyde biosynthesis", "negative regulation of chanoclavine-I aldehyde synthesis", "down regulation of chanoclavine-I aldehyde anabolism", "downregulation of chanoclavine-I aldehyde biosynthesis", "negative regulation of chanoclavine-I aldehyde biosynthesis", "down-regulation of chanoclavine-I aldehyde synthesis", "downregulation of chanoclavine-I aldehyde formation", "inhibition of chanoclavine-I aldehyde formation", "inhibition of chanoclavine-I aldehyde anabolism", "down-regulation of chanoclavine-I aldehyde anabolism", "downregulation of chanoclavine-I aldehyde synthesis", "down regulation of chanoclavine-I aldehyde synthesis", "down regulation of chanoclavine-I aldehyde formation", "down regulation of chanoclavine-I aldehyde biosynthesis", "down-regulation of chanoclavine-I aldehyde formation", "negative regulation of chanoclavine-I aldehyde formation", "inhibition of chanoclavine-I aldehyde synthesis", "down-regulation of chanoclavine-I aldehyde biosynthetic process", "down regulation of chanoclavine-I aldehyde biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of chanoclavine-I aldehyde biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548026", "aliases": ["regulation of chanoclavine-I aldehyde biosynthesis", "regulation of chanoclavine-I aldehyde synthesis", "regulation of chanoclavine-I aldehyde anabolism", "regulation of chanoclavine-I aldehyde formation"], "types": ["T044"], "canonical_name": "regulation of chanoclavine-I aldehyde biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548027", "aliases": ["up regulation of chanoclavine-I synthesis", "up regulation of chanoclavine-I biosynthesis", "up-regulation of chanoclavine-I biosynthetic process", "activation of chanoclavine-I biosynthesis", "activation of chanoclavine-I anabolism", "positive regulation of chanoclavine-I biosynthesis", "up-regulation of chanoclavine-I formation", "upregulation of chanoclavine-I anabolism", "positive regulation of chanoclavine-I synthesis", "positive regulation of chanoclavine-I anabolism", "upregulation of chanoclavine-I synthesis", "up-regulation of chanoclavine-I synthesis", "up regulation of chanoclavine-I anabolism", "up-regulation of chanoclavine-I anabolism", "upregulation of chanoclavine-I biosynthetic process", "up-regulation of chanoclavine-I biosynthesis", "upregulation of chanoclavine-I formation", "upregulation of chanoclavine-I biosynthesis", "up regulation of chanoclavine-I biosynthetic process", "activation of chanoclavine-I synthesis", "positive regulation of chanoclavine-I formation", "activation of chanoclavine-I formation", "up regulation of chanoclavine-I formation"], "types": ["T044"], "canonical_name": "positive regulation of chanoclavine-I biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of chanoclavine-I biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548028", "aliases": ["down regulation of chanoclavine-I synthesis", "down regulation of chanoclavine-I biosynthesis", "negative regulation of chanoclavine-I formation", "downregulation of chanoclavine-I biosynthesis", "down regulation of chanoclavine-I formation", "inhibition of chanoclavine-I biosynthesis", "downregulation of chanoclavine-I formation", "inhibition of chanoclavine-I anabolism", "down-regulation of chanoclavine-I biosynthesis", "downregulation of chanoclavine-I biosynthetic process", "inhibition of chanoclavine-I synthesis", "down regulation of chanoclavine-I anabolism", "negative regulation of chanoclavine-I anabolism", "down-regulation of chanoclavine-I anabolism", "downregulation of chanoclavine-I synthesis", "negative regulation of chanoclavine-I synthesis", "negative regulation of chanoclavine-I biosynthesis", "down-regulation of chanoclavine-I synthesis", "down regulation of chanoclavine-I biosynthetic process", "down-regulation of chanoclavine-I biosynthetic process", "downregulation of chanoclavine-I anabolism", "down-regulation of chanoclavine-I formation", "inhibition of chanoclavine-I formation"], "types": ["T044"], "canonical_name": "negative regulation of chanoclavine-I biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548029", "aliases": ["regulation of chanoclavine-I biosynthesis", "regulation of chanoclavine-I anabolism", "regulation of chanoclavine-I synthesis", "regulation of chanoclavine-I formation"], "types": ["T044"], "canonical_name": "regulation of chanoclavine-I biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of chanoclavine-I biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548030", "aliases": ["inhibition of austinol synthesis", "down regulation of austinol synthesis", "negative regulation of austinol biosynthesis", "negative regulation of austinol formation", "downregulation of austinol anabolism", "down-regulation of austinol biosynthesis", "down regulation of austinol biosynthesis", "inhibition of austinol anabolism", "down regulation of austinol biosynthetic process", "down regulation of austinol anabolism", "down-regulation of austinol anabolism", "negative regulation of austinol synthesis", "inhibition of austinol formation", "down regulation of austinol formation", "downregulation of austinol biosynthetic process", "down-regulation of austinol formation", "downregulation of austinol synthesis", "downregulation of austinol biosynthesis", "down-regulation of austinol synthesis", "downregulation of austinol formation", "down-regulation of austinol biosynthetic process", "negative regulation of austinol anabolism", "inhibition of austinol biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of austinol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of austinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548031", "aliases": ["regulation of austinol biosynthesis", "regulation of austinol formation", "regulation of austinol synthesis", "regulation of austinol anabolism"], "types": ["T044"], "canonical_name": "regulation of austinol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of austinol biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548032", "aliases": ["up regulation of asperfuranone formation", "positive regulation of asperfuranone formation", "upregulation of asperfuranone biosynthetic process", "up regulation of asperfuranone synthesis", "upregulation of asperfuranone synthesis", "up-regulation of asperfuranone biosynthetic process", "up-regulation of asperfuranone formation", "upregulation of asperfuranone anabolism", "activation of asperfuranone anabolism", "up-regulation of asperfuranone synthesis", "up-regulation of asperfuranone anabolism", "up regulation of asperfuranone anabolism", "activation of asperfuranone biosynthesis", "up-regulation of asperfuranone biosynthesis", "up regulation of asperfuranone biosynthesis", "positive regulation of asperfuranone biosynthesis", "upregulation of asperfuranone biosynthesis", "upregulation of asperfuranone formation", "up regulation of asperfuranone biosynthetic process", "positive regulation of asperfuranone anabolism", "activation of asperfuranone synthesis", "activation of asperfuranone formation", "positive regulation of asperfuranone synthesis"], "types": ["T044"], "canonical_name": "positive regulation of asperfuranone biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of asperfuranone biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548033", "aliases": ["down-regulation of asperfuranone anabolism", "negative regulation of asperfuranone synthesis", "down-regulation of asperfuranone biosynthesis", "inhibition of asperfuranone anabolism", "downregulation of asperfuranone synthesis", "downregulation of asperfuranone biosynthesis", "down regulation of asperfuranone biosynthetic process", "down regulation of asperfuranone biosynthesis", "negative regulation of asperfuranone biosynthesis", "down regulation of asperfuranone anabolism", "downregulation of asperfuranone anabolism", "inhibition of asperfuranone biosynthesis", "negative regulation of asperfuranone anabolism", "negative regulation of asperfuranone formation", "downregulation of asperfuranone biosynthetic process", "downregulation of asperfuranone formation", "down regulation of asperfuranone synthesis", "down-regulation of asperfuranone biosynthetic process", "inhibition of asperfuranone formation", "down-regulation of asperfuranone synthesis", "down regulation of asperfuranone formation", "down-regulation of asperfuranone formation", "inhibition of asperfuranone synthesis"], "types": ["T044"], "canonical_name": "negative regulation of asperfuranone biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of asperfuranone biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548034", "aliases": ["regulation of asperfuranone synthesis", "regulation of asperfuranone biosynthesis", "regulation of asperfuranone anabolism", "regulation of asperfuranone formation"], "types": ["T044"], "canonical_name": "regulation of asperfuranone biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of asperfuranone biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548035", "aliases": ["heptadecane anabolism", "heptadecane biosynthesis", "heptadecane formation", "heptadecane synthesis"], "types": ["T044"], "canonical_name": "heptadecane biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of heptadecane. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548036", "aliases": ["heptadecane metabolism"], "types": ["T043"], "canonical_name": "heptadecane metabolic process", "definition": "The chemical reactions and pathways involving heptadecane. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548037", "aliases": ["pentadecane synthesis", "pentadecane formation", "pentadecane anabolism", "pentadecane biosynthesis"], "types": ["T044"], "canonical_name": "pentadecane biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pentadecane. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548038", "aliases": ["pentadecane metabolism"], "types": ["T044"], "canonical_name": "pentadecane metabolic process", "definition": "The chemical reactions and pathways involving pentadecane. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548039", "aliases": ["tridecane synthesis", "tridecane biosynthesis", "tridecane anabolism", "tridecane formation"], "types": ["T044"], "canonical_name": "tridecane biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tridecane. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548040", "aliases": ["tridecane metabolism"], "types": ["T043"], "canonical_name": "tridecane metabolic process", "definition": "The chemical reactions and pathways involving tridecane. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548041", "aliases": ["methanophenazine biosynthesis", "methanophenazine synthesis", "methanophenazine anabolism", "methanophenazine formation"], "types": ["T044"], "canonical_name": "methanophenazine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of methanophenazine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548042", "aliases": ["methanophenazine metabolism"], "types": ["T044"], "canonical_name": "methanophenazine metabolic process", "definition": "The chemical reactions and pathways involving methanophenazine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548043", "aliases": ["up regulation of arugosin biosynthetic process", "up-regulation of arugosin formation", "upregulation of arugosin synthesis", "up-regulation of arugosin anabolism", "up regulation of arugosin biosynthesis", "positive regulation of arugosin synthesis", "upregulation of arugosin biosynthetic process", "upregulation of arugosin anabolism", "activation of arugosin formation", "up-regulation of arugosin synthesis", "up-regulation of arugosin biosynthetic process", "activation of arugosin anabolism", "upregulation of arugosin formation", "positive regulation of arugosin anabolism", "up regulation of arugosin formation", "up regulation of arugosin anabolism", "activation of arugosin biosynthesis", "up-regulation of arugosin biosynthesis", "positive regulation of arugosin formation", "upregulation of arugosin biosynthesis", "up regulation of arugosin synthesis", "positive regulation of arugosin biosynthesis", "activation of arugosin synthesis"], "types": ["T044"], "canonical_name": "positive regulation of arugosin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of arugosin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548044", "aliases": ["downregulation of arugosin synthesis", "inhibition of arugosin anabolism", "negative regulation of arugosin anabolism", "inhibition of arugosin synthesis", "negative regulation of arugosin synthesis", "down-regulation of arugosin biosynthetic process", "down regulation of arugosin anabolism", "down regulation of arugosin formation", "down-regulation of arugosin biosynthesis", "downregulation of arugosin formation", "negative regulation of arugosin formation", "down regulation of arugosin synthesis", "down-regulation of arugosin formation", "downregulation of arugosin biosynthetic process", "inhibition of arugosin biosynthesis", "down regulation of arugosin biosynthesis", "down-regulation of arugosin anabolism", "negative regulation of arugosin biosynthesis", "down-regulation of arugosin synthesis", "down regulation of arugosin biosynthetic process", "downregulation of arugosin anabolism", "downregulation of arugosin biosynthesis", "inhibition of arugosin formation"], "types": ["T044"], "canonical_name": "negative regulation of arugosin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of arugosin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548045", "aliases": ["regulation of arugosin biosynthesis", "regulation of arugosin anabolism", "regulation of arugosin formation", "regulation of arugosin synthesis"], "types": ["T044"], "canonical_name": "regulation of arugosin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of arugosin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548046", "aliases": ["up-regulation of mononuclear phagocyte aggregation", "activation of mononuclear phagocyte aggregation", "up regulation of monocyte aggregation", "up-regulation of monocyte aggregation", "upregulation of mononuclear phagocyte aggregation", "up regulation of mononuclear phagocyte aggregation", "upregulation of monocyte aggregation", "positive regulation of mononuclear phagocyte aggregation"], "types": ["T043"], "canonical_name": "positive regulation of monocyte aggregation", "definition": "Any process that activates or increases the frequency, rate or extent of monocyte aggregation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548047", "aliases": ["down regulation of mononuclear phagocyte aggregation", "down-regulation of mononuclear phagocyte aggregation", "inhibition of mononuclear phagocyte aggregation", "down regulation of monocyte aggregation", "down-regulation of monocyte aggregation", "downregulation of mononuclear phagocyte aggregation", "downregulation of monocyte aggregation", "negative regulation of mononuclear phagocyte aggregation"], "types": ["T043"], "canonical_name": "negative regulation of monocyte aggregation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte aggregation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548048", "aliases": ["regulation of mononuclear phagocyte aggregation"], "types": ["T043"], "canonical_name": "regulation of monocyte aggregation", "definition": "Any process that modulates the frequency, rate or extent of monocyte aggregation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548049", "aliases": ["acetyl ester biosynthetic process", "acetate ester anabolism", "acetyl ester biosynthesis", "acetate ester biosynthesis", "acetate ester formation", "acetate ester synthesis"], "types": ["T044"], "canonical_name": "acetate ester biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. [GOC:TermGenie, PMID:15042596]"}
{"concept_id": "C3548050", "aliases": ["acetyl ester metabolism", "acetate ester metabolism", "acetyl ester metabolic process"], "types": ["T040"], "canonical_name": "acetate ester metabolic process", "definition": "The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. [GOC:TermGenie]"}
{"concept_id": "C3548051", "aliases": ["regulation of shoot morphogenesis"], "types": ["T039"], "canonical_name": "regulation of shoot system morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of shoot morphogenesis. [GOC:TermGenie]"}
{"concept_id": "C3548052", "aliases": ["emericellamide A biosynthesis", "emericellamide A anabolism", "emericellamide A formation", "emericellamide A synthesis"], "types": ["T044"], "canonical_name": "emericellamide A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of emericellamide A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548053", "aliases": ["emericellamide A degradation", "emericellamide A catabolism", "emericellamide A breakdown"], "types": ["T044"], "canonical_name": "emericellamide A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of emericellamide A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548054", "aliases": ["emericellamide A metabolism"], "types": ["T044"], "canonical_name": "emericellamide A metabolic process", "definition": "The chemical reactions and pathways involving emericellamide A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548055", "aliases": ["F-9775B formation", "F-9775B anabolism", "F-9775B biosynthesis", "F-9775B synthesis"], "types": ["T044"], "canonical_name": "F-9775B biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of F-9775B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548056", "aliases": ["F-9775B breakdown", "F-9775B catabolism", "F-9775B degradation"], "types": ["T044"], "canonical_name": "F-9775B catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of F-9775B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548057", "aliases": ["F-9775B metabolism"], "types": ["T044"], "canonical_name": "F-9775B metabolic process", "definition": "The chemical reactions and pathways involving F-9775B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548058", "aliases": ["F-9775A formation", "F-9775A biosynthesis", "F-9775A synthesis", "F-9775A anabolism"], "types": ["T044"], "canonical_name": "F-9775A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of F-9775A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548059", "aliases": ["F-9775A degradation", "F-9775A catabolism", "F-9775A breakdown"], "types": ["T044"], "canonical_name": "F-9775A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of F-9775A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548060", "aliases": ["F-9775A metabolism"], "types": ["T044"], "canonical_name": "F-9775A metabolic process", "definition": "The chemical reactions and pathways involving F-9775A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548061", "aliases": ["tensidol B anabolism", "tensidol B biosynthesis", "tensidol B synthesis", "tensidol B formation"], "types": ["T044"], "canonical_name": "tensidol B biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tensidol B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548062", "aliases": ["tensidol B catabolism", "tensidol B degradation", "tensidol B breakdown"], "types": ["T044"], "canonical_name": "tensidol B catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tensidol B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548063", "aliases": ["tensidol B metabolism"], "types": ["T044"], "canonical_name": "tensidol B metabolic process", "definition": "The chemical reactions and pathways involving tensidol B. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548064", "aliases": ["tensidol A catabolism", "tensidol A breakdown", "tensidol A degradation"], "types": ["T044"], "canonical_name": "tensidol A catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of tensidol A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548065", "aliases": ["tensidol A metabolism"], "types": ["T044"], "canonical_name": "tensidol A metabolic process", "definition": "The chemical reactions and pathways involving tensidol A. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548066", "aliases": ["endocrocin synthesis", "endocrocin biosynthesis", "endocrocin formation", "endocrocin anabolism"], "types": ["T044"], "canonical_name": "endocrocin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of endocrocin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548067", "aliases": ["endocrocin degradation", "endocrocin breakdown", "endocrocin catabolism"], "types": ["T044"], "canonical_name": "endocrocin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of endocrocin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548068", "aliases": ["endocrocin metabolism"], "types": ["T044"], "canonical_name": "endocrocin metabolic process", "definition": "The chemical reactions and pathways involving endocrocin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548069", "aliases": ["demethylkotanin synthesis", "demethylkotanin anabolism", "demethylkotanin formation", "demethylkotanin biosynthesis"], "types": ["T044"], "canonical_name": "demethylkotanin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of demethylkotanin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548070", "aliases": ["demethylkotanin degradation", "demethylkotanin catabolism", "demethylkotanin breakdown"], "types": ["T044"], "canonical_name": "demethylkotanin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of demethylkotanin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548071", "aliases": ["demethylkotanin metabolism"], "types": ["T044"], "canonical_name": "demethylkotanin metabolic process", "definition": "The chemical reactions and pathways involving demethylkotanin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548072", "aliases": ["(+)-kotanin anabolism", "(+)-kotanin synthesis", "(+)-kotanin biosynthesis", "(+)-kotanin formation"], "types": ["T044"], "canonical_name": "(+)-kotanin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (+)-kotanin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548073", "aliases": ["(+)-kotanin catabolism", "(+)-kotanin degradation", "(+)-kotanin breakdown"], "types": ["T044"], "canonical_name": "(+)-kotanin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (+)-kotanin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548074", "aliases": ["(+)-kotanin metabolism"], "types": ["T044"], "canonical_name": "(+)-kotanin metabolic process", "definition": "The chemical reactions and pathways involving (+)-kotanin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548075", "aliases": ["violaceol II anabolism", "violaceol II synthesis", "violaceol II biosynthesis", "violaceol II formation"], "types": ["T044"], "canonical_name": "violaceol II biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of violaceol II. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548076", "aliases": ["violaceol II breakdown", "violaceol II degradation", "violaceol II catabolism"], "types": ["T044"], "canonical_name": "violaceol II catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of violaceol II. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548077", "aliases": ["violaceol II metabolism"], "types": ["T044"], "canonical_name": "violaceol II metabolic process", "definition": "The chemical reactions and pathways involving violaceol II. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548078", "aliases": ["violaceol I anabolism", "violaceol I formation", "violaceol I synthesis", "violaceol I biosynthesis"], "types": ["T044"], "canonical_name": "violaceol I biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of violaceol I. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548079", "aliases": ["violaceol I degradation", "violaceol I breakdown", "violaceol I catabolism"], "types": ["T044"], "canonical_name": "violaceol I catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of violaceol I. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548080", "aliases": ["violaceol I metabolism"], "types": ["T044"], "canonical_name": "violaceol I metabolic process", "definition": "The chemical reactions and pathways involving violaceol I. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548081", "aliases": ["arugosin synthesis", "arugosin anabolism", "arugosin biosynthesis", "arugosin formation"], "types": ["T044"], "canonical_name": "arugosin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of arugosin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548082", "aliases": ["arugosin degradation", "arugosin breakdown", "arugosin catabolism"], "types": ["T044"], "canonical_name": "arugosin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of arugosin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548083", "aliases": ["arugosin metabolism"], "types": ["T044"], "canonical_name": "arugosin metabolic process", "definition": "The chemical reactions and pathways involving arugosin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548084", "aliases": ["o-orsellinic acid biosynthesis", "o-orsellinic acid anabolism", "o-orsellinic acid formation", "o-orsellinic acid synthesis"], "types": ["T044"], "canonical_name": "o-orsellinic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of o-orsellinic acid. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548085", "aliases": ["o-orsellinic acid breakdown", "o-orsellinic acid degradation", "o-orsellinic acid catabolism"], "types": ["T044"], "canonical_name": "o-orsellinic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of o-orsellinic acid. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548086", "aliases": ["o-orsellinic acid metabolism"], "types": ["T044"], "canonical_name": "o-orsellinic acid metabolic process", "definition": "The chemical reactions and pathways involving o-orsellinic acid. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548087", "aliases": ["(17Z)-protosta-17(20),24-dien-3beta-ol synthesis", "(17Z)-protosta-17(20),24-dien-3beta-ol biosynthesis", "(17Z)-protosta-17(20),24-dien-3beta-ol anabolism", "(17Z)-protosta-17(20),24-dien-3beta-ol formation"], "types": ["T044"], "canonical_name": "(17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (17Z)-protosta-17(20),24-dien-3beta-ol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548088", "aliases": ["(17Z)-protosta-17(20),24-dien-3beta-ol catabolism", "(17Z)-protosta-17(20),24-dien-3beta-ol breakdown", "(17Z)-protosta-17(20),24-dien-3beta-ol degradation"], "types": ["T044"], "canonical_name": "(17Z)-protosta-17(20),24-dien-3beta-ol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (17Z)-protosta-17(20),24-dien-3beta-ol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548089", "aliases": ["(17Z)-protosta-17(20),24-dien-3beta-ol metabolism"], "types": ["T044"], "canonical_name": "(17Z)-protosta-17(20),24-dien-3beta-ol metabolic process", "definition": "The chemical reactions and pathways involving (17Z)-protosta-17(20),24-dien-3beta-ol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548090", "aliases": ["gerfelin formation", "gerfelin anabolism", "gerfelin biosynthesis", "gerfelin synthesis"], "types": ["T044"], "canonical_name": "gerfelin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of gerfelin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548091", "aliases": ["gerfelin breakdown", "gerfelin degradation", "gerfelin catabolism"], "types": ["T044"], "canonical_name": "gerfelin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of gerfelin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548092", "aliases": ["gerfelin metabolism"], "types": ["T044"], "canonical_name": "gerfelin metabolic process", "definition": "The chemical reactions and pathways involving gerfelin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548093", "aliases": ["emodin biosynthesis", "emodin formation", "emodin anabolism", "emodin synthesis"], "types": ["T044"], "canonical_name": "emodin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of emodin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548094", "aliases": ["emodin degradation", "emodin breakdown", "emodin catabolism"], "types": ["T044"], "canonical_name": "emodin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of emodin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548095", "aliases": ["emodin metabolism"], "types": ["T044"], "canonical_name": "emodin metabolic process", "definition": "The chemical reactions and pathways involving emodin. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548096", "aliases": ["diorcinol formation", "diorcinol biosynthesis", "diorcinol anabolism", "diorcinol synthesis"], "types": ["T044"], "canonical_name": "diorcinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of diorcinol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548097", "aliases": ["diorcinol catabolism", "diorcinol degradation", "diorcinol breakdown"], "types": ["T044"], "canonical_name": "diorcinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of diorcinol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548098", "aliases": ["diorcinol metabolism"], "types": ["T044"], "canonical_name": "diorcinol metabolic process", "definition": "The chemical reactions and pathways involving diorcinol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548099", "aliases": ["chanoclavine-I aldehyde formation", "chanoclavine-I aldehyde anabolism", "chanoclavine-I aldehyde synthesis", "chanoclavine-I aldehyde biosynthesis"], "types": ["T044"], "canonical_name": "chanoclavine-I aldehyde biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of chanoclavine-I aldehyde. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548100", "aliases": ["chanoclavine-I aldehyde degradation", "chanoclavine-I aldehyde catabolism", "chanoclavine-I aldehyde breakdown"], "types": ["T044"], "canonical_name": "chanoclavine-I aldehyde catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of chanoclavine-I aldehyde. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548101", "aliases": ["chanoclavine-I aldehyde metabolism"], "types": ["T044"], "canonical_name": "chanoclavine-I aldehyde metabolic process", "definition": "The chemical reactions and pathways involving chanoclavine-I aldehyde. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548102", "aliases": ["chanoclavine-I anabolism", "chanoclavine-I biosynthesis", "chanoclavine-I formation", "chanoclavine-I synthesis"], "types": ["T044"], "canonical_name": "chanoclavine-I biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of chanoclavine-I. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548103", "aliases": ["chanoclavine-I catabolism", "chanoclavine-I degradation", "chanoclavine-I breakdown"], "types": ["T044"], "canonical_name": "chanoclavine-I catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of chanoclavine-I. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548104", "aliases": ["chanoclavine-I metabolism"], "types": ["T044"], "canonical_name": "chanoclavine-I metabolic process", "definition": "The chemical reactions and pathways involving chanoclavine-I. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548105", "aliases": ["dehydroaustinol synthesis", "dehydroaustinol formation", "dehydroaustinol anabolism", "dehydroaustinol biosynthesis"], "types": ["T044"], "canonical_name": "dehydroaustinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dehydroaustinol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548106", "aliases": ["dehydroaustinol catabolism", "dehydroaustinol breakdown", "dehydroaustinol degradation"], "types": ["T044"], "canonical_name": "dehydroaustinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of dehydroaustinol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548107", "aliases": ["dehydroaustinol metabolism"], "types": ["T044"], "canonical_name": "dehydroaustinol metabolic process", "definition": "The chemical reactions and pathways involving dehydroaustinol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548108", "aliases": ["austinol anabolism", "austinol formation", "austinol biosynthesis", "austinol synthesis"], "types": ["T044"], "canonical_name": "austinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of austinol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548109", "aliases": ["austinol catabolism", "austinol degradation", "austinol breakdown"], "types": ["T044"], "canonical_name": "austinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of austinol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548110", "aliases": ["austinol metabolism"], "types": ["T044"], "canonical_name": "austinol metabolic process", "definition": "The chemical reactions and pathways involving austinol. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548111", "aliases": ["emericellamide anabolism", "emericellamide formation", "emericellamide biosynthesis", "emericellamide synthesis"], "types": ["T044"], "canonical_name": "emericellamide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of emericellamide. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548112", "aliases": ["emericellamide breakdown", "emericellamide degradation", "emericellamide catabolism"], "types": ["T044"], "canonical_name": "emericellamide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of emericellamide. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548113", "aliases": ["emericellamide metabolism"], "types": ["T044"], "canonical_name": "emericellamide metabolic process", "definition": "The chemical reactions and pathways involving emericellamide. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548114", "aliases": ["asperfuranone synthesis", "asperfuranone formation", "asperfuranone biosynthesis", "asperfuranone anabolism"], "types": ["T044"], "canonical_name": "asperfuranone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of asperfuranone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548115", "aliases": ["asperfuranone breakdown", "asperfuranone degradation", "asperfuranone catabolism"], "types": ["T044"], "canonical_name": "asperfuranone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of asperfuranone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548116", "aliases": ["asperfuranone metabolism"], "types": ["T044"], "canonical_name": "asperfuranone metabolic process", "definition": "The chemical reactions and pathways involving asperfuranone. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548117", "aliases": ["N',N'',N'''-triacetylfusarinine C anabolism", "N',N'',N'''-triacetylfusarinine C biosynthesis", "N',N'',N'''-triacetylfusarinine C synthesis", "N',N'',N'''-triacetylfusarinine C formation"], "types": ["T044"], "canonical_name": "N',N'',N'''-triacetylfusarinine C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548118", "aliases": ["N',N'',N'''-triacetylfusarinine C breakdown", "N',N'',N'''-triacetylfusarinine C catabolism", "N',N'',N'''-triacetylfusarinine C degradation"], "types": ["T044"], "canonical_name": "N',N'',N'''-triacetylfusarinine C catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of N',N'',N'''-triacetylfusarinine C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548119", "aliases": ["N',N'',N'''-triacetylfusarinine C metabolism"], "types": ["T044"], "canonical_name": "N',N'',N'''-triacetylfusarinine C metabolic process", "definition": "The chemical reactions and pathways involving N',N'',N'''-triacetylfusarinine C. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548120", "aliases": ["protoheme degradation", "heme B catabolism", "protoheme catabolic process", "heme B breakdown", "heme B degradation"], "types": ["T044"], "canonical_name": "heme B catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. [GOC:TermGenie, GOC:yaf, PMID:28352909, UniPathway:UPA00684]"}
{"concept_id": "C3548124", "aliases": ["up regulation of purine nucleotide metabolism", "up regulation of purine nucleotide metabolic process", "up-regulation of purine nucleotide metabolic process", "upregulation of purine nucleotide metabolic process", "positive regulation of purine nucleotide metabolism", "up-regulation of purine nucleotide metabolism", "upregulation of purine nucleotide metabolism"], "types": ["T044"], "canonical_name": "positive regulation of purine nucleotide metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process. [GOC:TermGenie]"}
{"concept_id": "C3548125", "aliases": ["negative regulation of purine nucleotide metabolism", "down-regulation of purine nucleotide metabolic process", "down-regulation of purine nucleotide metabolism", "down regulation of purine nucleotide metabolism", "downregulation of purine nucleotide metabolism", "down regulation of purine nucleotide metabolic process", "downregulation of purine nucleotide metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of purine nucleotide metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process. [GOC:TermGenie]"}
{"concept_id": "C3548126", "aliases": ["regulation of purine nucleotide metabolism"], "types": ["T044"], "canonical_name": "regulation of purine nucleotide metabolic process", "definition": "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process. [GOC:TermGenie]"}
{"concept_id": "C3548127", "aliases": ["fumonisin biosynthesis", "fumonisin formation", "fumonisin anabolism", "fumonisin synthesis"], "types": ["T044"], "canonical_name": "fumonisin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumonisin. [GOC:TermGenie]"}
{"concept_id": "C3548128", "aliases": [], "types": ["T044"], "canonical_name": "palmitic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of palmitic acid. [GOC:TermGenie]"}
{"concept_id": "C3548129", "aliases": [], "types": ["T044"], "canonical_name": "palmitic acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of palmitic acid. [GOC:TermGenie]"}
{"concept_id": "C3548130", "aliases": [], "types": ["T044"], "canonical_name": "palmitic acid metabolic process", "definition": "The chemical reactions and pathways involving palmitic acid. [GOC:TermGenie]"}
{"concept_id": "C3548134", "aliases": ["up-regulation of response to amylopectin", "upregulation of response to amylopectin", "up regulation of response to amylopectin"], "types": ["T044"], "canonical_name": "positive regulation of response to amylopectin", "definition": "Any process that activates or increases the frequency, rate or extent of response to amylopectin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548135", "aliases": ["down regulation of response to amylopectin", "down-regulation of response to amylopectin", "downregulation of response to amylopectin"], "types": ["T038"], "canonical_name": "negative regulation of response to amylopectin", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to amylopectin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548136", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to amylopectin", "definition": "Any process that modulates the frequency, rate or extent of response to amylopectin. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548137", "aliases": ["up-regulation of response to pullulan", "up regulation of response to pullulan", "upregulation of response to pullulan"], "types": ["T044"], "canonical_name": "positive regulation of response to pullulan", "definition": "Any process that activates or increases the frequency, rate or extent of response to pullulan. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548138", "aliases": ["down regulation of response to pullulan", "downregulation of response to pullulan", "down-regulation of response to pullulan"], "types": ["T038"], "canonical_name": "negative regulation of response to pullulan", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to pullulan. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548139", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to pullulan", "definition": "Any process that modulates the frequency, rate or extent of response to pullulan. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548140", "aliases": ["positive regulation of xylose catabolism to ethanol", "up-regulation of xylose catabolism to ethanol", "upregulation of xylose catabolism to ethanol", "up regulation of xylose catabolism to ethanol", "upregulation of xylose catabolic process to ethanol", "activation of xylose catabolism to ethanol", "up-regulation of xylose catabolic process to ethanol", "up regulation of xylose catabolic process to ethanol"], "types": ["T044"], "canonical_name": "positive regulation of xylose catabolic process to ethanol", "definition": "Any process that activates or increases the frequency, rate or extent of xylose catabolic process to ethanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548141", "aliases": ["downregulation of xylose catabolism to ethanol", "negative regulation of xylose catabolism to ethanol", "inhibition of xylose catabolism to ethanol", "down regulation of xylose catabolism to ethanol", "downregulation of xylose catabolic process to ethanol", "down-regulation of xylose catabolic process to ethanol", "down regulation of xylose catabolic process to ethanol", "down-regulation of xylose catabolism to ethanol"], "types": ["T044"], "canonical_name": "negative regulation of xylose catabolic process to ethanol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of xylose catabolic process to ethanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548142", "aliases": ["regulation of xylose catabolism to ethanol"], "types": ["T044"], "canonical_name": "regulation of xylose catabolic process to ethanol", "definition": "Any process that modulates the frequency, rate or extent of xylose catabolic process to ethanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548143", "aliases": ["up-regulation of assembly of starch utilization system complex", "activation of SUS complex assembly", "up-regulation of starch utilization system complex assembly", "activation of starch utilization system complex assembly", "up regulation of assembly of starch utilization system complex", "up-regulation of SUS complex assembly", "upregulation of starch utilization system complex assembly", "up regulation of SUS complex assembly", "up regulation of starch utilization system complex assembly", "positive regulation of SUS complex assembly", "positive regulation of assembly of starch utilization system complex", "upregulation of SUS complex assembly", "activation of assembly of starch utilization system complex", "upregulation of assembly of starch utilization system complex"], "types": ["T043"], "canonical_name": "positive regulation of starch utilization system complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of starch utilization system complex assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548144", "aliases": ["downregulation of assembly of starch utilization system complex", "down-regulation of assembly of starch utilization system complex", "negative regulation of assembly of starch utilization system complex", "inhibition of SUS complex assembly", "inhibition of assembly of starch utilization system complex", "down-regulation of starch utilization system complex assembly", "negative regulation of SUS complex assembly", "down regulation of starch utilization system complex assembly", "down regulation of SUS complex assembly", "downregulation of starch utilization system complex assembly", "down-regulation of SUS complex assembly", "inhibition of starch utilization system complex assembly", "downregulation of SUS complex assembly", "down regulation of assembly of starch utilization system complex"], "types": ["T043"], "canonical_name": "negative regulation of starch utilization system complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of starch utilization system complex assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548145", "aliases": ["regulation of SUS complex assembly", "regulation of assembly of starch utilization system complex"], "types": ["T040"], "canonical_name": "regulation of starch utilization system complex assembly", "definition": "Any process that modulates the frequency, rate or extent of starch utilization system complex assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548146", "aliases": ["down regulation of pentose catabolic process to ethanol", "down regulation of pentose catabolism to ethanol", "down-regulation of pentose catabolic process to ethanol", "downregulation of pentose catabolic process to ethanol", "downregulation of pentose catabolism to ethanol", "inhibition of pentose catabolism to ethanol", "negative regulation of pentose catabolism to ethanol", "down-regulation of pentose catabolism to ethanol"], "types": ["T044"], "canonical_name": "negative regulation of pentose catabolic process to ethanol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pentose catabolic process to ethanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548147", "aliases": ["regulation of pentose catabolism to ethanol"], "types": ["T044"], "canonical_name": "regulation of pentose catabolic process to ethanol", "definition": "Any process that modulates the frequency, rate or extent of pentose catabolic process to ethanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548148", "aliases": ["negative regulation of FeMoco assembly", "down-regulation of iron-sulfur-molybdenum cofactor assembly", "negative regulation of FeMoco biosynthetic process", "inhibition of iron molybdenum cofactor biosynthesis", "inhibition of FeMoco biosynthetic process", "inhibition of FeMoco assembly", "down-regulation of iron molybdenum cofactor biosynthetic process", "down regulation of iron molybdenum cofactor assembly", "negative regulation of iron molybdenum cofactor assembly", "downregulation of iron molybdenum cofactor assembly", "inhibition of iron molybdenum cofactor biosynthetic process", "downregulation of iron-sulfur-molybdenum cofactor assembly", "downregulation of FeMoco assembly", "negative regulation of iron molybdenum cofactor biosynthesis", "down regulation of FeMoco biosynthetic process", "down-regulation of FeMoco assembly", "down-regulation of iron molybdenum cofactor assembly", "downregulation of iron molybdenum cofactor biosynthesis", "down regulation of iron-sulfur-molybdenum cofactor assembly", "inhibition of iron molybdenum cofactor assembly", "down regulation of iron molybdenum cofactor biosynthesis", "down regulation of FeMoco assembly", "negative regulation of iron molybdenum cofactor biosynthetic process", "downregulation of FeMoco biosynthetic process", "downregulation of iron molybdenum cofactor biosynthetic process", "down-regulation of iron molybdenum cofactor biosynthesis", "down-regulation of FeMoco biosynthetic process", "down regulation of iron molybdenum cofactor biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of iron-sulfur-molybdenum cofactor assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548149", "aliases": ["regulation of iron molybdenum cofactor biosynthetic process", "regulation of iron molybdenum cofactor biosynthesis", "regulation of FeMoco assembly", "regulation of FeMoco biosynthetic process", "regulation of iron molybdenum cofactor assembly"], "types": ["T044"], "canonical_name": "regulation of iron-sulfur-molybdenum cofactor assembly", "definition": "Any process that modulates the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548150", "aliases": ["upregulation of cellulosome assembly", "up regulation of cellulosome assembly", "up-regulation of cellulosome assembly"], "types": ["T043"], "canonical_name": "positive regulation of cellulosome assembly", "definition": "Any process that activates or increases the frequency, rate or extent of cellulosome assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548151", "aliases": ["downregulation of cellulosome assembly", "down regulation of cellulosome assembly", "down-regulation of cellulosome assembly"], "types": ["T043"], "canonical_name": "negative regulation of cellulosome assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellulosome assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548152", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellulosome assembly", "definition": "Any process that modulates the frequency, rate or extent of cellulosome assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548153", "aliases": ["down regulation of butyryl-CoA catabolic process to butyrate", "inhibition of butyryl-CoA catabolism to butyrate", "down regulation of butyryl-CoA catabolism to butyrate", "downregulation of butyryl-CoA catabolism to butyrate", "downregulation of butyryl-CoA catabolic process to butyrate", "down-regulation of butyryl-CoA catabolism to butyrate", "down-regulation of butyryl-CoA catabolic process to butyrate", "negative regulation of butyryl-CoA catabolism to butyrate"], "types": ["T044"], "canonical_name": "negative regulation of butyryl-CoA catabolic process to butyrate", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butyrate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548154", "aliases": ["regulation of butyryl-CoA catabolism to butyrate"], "types": ["T044"], "canonical_name": "regulation of butyryl-CoA catabolic process to butyrate", "definition": "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butyrate. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548155", "aliases": ["down regulation of butyryl-CoA catabolic process to butanol", "downregulation of butyryl-CoA catabolism to butanol", "negative regulation of butyryl-CoA catabolism to butanol", "inhibition of butyryl-CoA catabolism to butanol", "down-regulation of butyryl-CoA catabolism to butanol", "downregulation of butyryl-CoA catabolic process to butanol", "down regulation of butyryl-CoA catabolism to butanol", "down-regulation of butyryl-CoA catabolic process to butanol"], "types": ["T044"], "canonical_name": "negative regulation of butyryl-CoA catabolic process to butanol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548156", "aliases": ["regulation of butyryl-CoA catabolism to butanol"], "types": ["T044"], "canonical_name": "regulation of butyryl-CoA catabolic process to butanol", "definition": "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butanol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548157", "aliases": ["down-regulation of butyryl-CoA biosynthesis from acetyl-CoA", "downregulation of butyryl-CoA biosynthesis from acetyl-CoA", "down regulation of butyryl-CoA biosynthetic process from acetyl-CoA", "downregulation of butyryl-CoA biosynthetic process from acetyl-CoA", "down regulation of butyryl-CoA biosynthesis from acetyl-CoA", "inhibition of butyryl-CoA biosynthesis from acetyl-CoA", "down-regulation of butyryl-CoA biosynthetic process from acetyl-CoA", "negative regulation of butyryl-CoA biosynthesis from acetyl-CoA"], "types": ["T040"], "canonical_name": "negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548158", "aliases": ["regulation of butyryl-CoA biosynthesis from acetyl-CoA"], "types": ["T043"], "canonical_name": "regulation of butyryl-CoA biosynthetic process from acetyl-CoA", "definition": "Any process that modulates the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548159", "aliases": ["negative regulation of 4Fe-4S cluster assembly", "downregulation of [4Fe-4S] cluster assembly", "down regulation of 4Fe-4S cluster assembly", "downregulation of 4Fe-4S cluster assembly", "down-regulation of 4Fe-4S cluster assembly", "down regulation of [4Fe-4S] cluster assembly", "down-regulation of [4Fe-4S] cluster assembly"], "types": ["T044"], "canonical_name": "negative regulation of [4Fe-4S] cluster assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of [4Fe-4S] cluster assembly. [GOC:mengo_curators, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3548161", "aliases": ["negative regulation of 2Fe-2S cluster assembly", "down regulation of [2Fe-2S] cluster assembly", "downregulation of 2Fe-2S cluster assembly", "downregulation of [2Fe-2S] cluster assembly", "down-regulation of 2Fe-2S cluster assembly", "down regulation of 2Fe-2S cluster assembly", "down-regulation of [2Fe-2S] cluster assembly"], "types": ["T044"], "canonical_name": "negative regulation of [2Fe-2S] cluster assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of [2Fe-2S] cluster assembly. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548162", "aliases": ["activation of Ac-MVA pathway", "up-regulation of isopentenyl diphosphate formation, mevalonate pathway", "activation of isopentenyl diphosphate synthesis, mevalonate pathway", "positive regulation of isopentenyl diphosphate synthesis, mevalonate pathway", "positive regulation of Ac-MVA pathway", "up-regulation of Ac-MVA pathway", "upregulation of Ac-MVA pathway", "positive regulation of isopentenyl diphosphate formation, mevalonate pathway", "up regulation of isopentenyl diphosphate anabolism, mevalonate pathway", "up regulation of isopentenyl diphosphate formation, mevalonate pathway", "upregulation of isopentenyl diphosphate synthesis, mevalonate pathway", "activation of isopentenyl diphosphate formation, mevalonate pathway", "up regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway", "up regulation of isopentenyl diphosphate synthesis, mevalonate pathway", "activation of acetate-mevalonate pathway", "positive regulation of acetate-mevalonate pathway", "up-regulation of isopentenyl diphosphate synthesis, mevalonate pathway", "upregulation of acetate-mevalonate pathway", "up-regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway", "upregulation of isopentenyl diphosphate formation, mevalonate pathway", "up regulation of acetate-mevalonate pathway", "up regulation of Ac-MVA pathway", "upregulation of isopentenyl diphosphate anabolism, mevalonate pathway", "upregulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway", "up-regulation of acetate-mevalonate pathway", "activation of isopentenyl diphosphate anabolism, mevalonate pathway", "up-regulation of isopentenyl diphosphate anabolism, mevalonate pathway", "positive regulation of isopentenyl diphosphate anabolism, mevalonate pathway"], "types": ["T044"], "canonical_name": "positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway", "definition": "Any process that activates or increases the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. [GOC:TermGenie]"}
{"concept_id": "C3548163", "aliases": ["up-regulation of protein targeting to vacuolar membrane", "upregulation of protein targeting to vacuolar membrane", "up regulation of protein targeting to vacuolar membrane"], "types": ["T043"], "canonical_name": "positive regulation of protein targeting to vacuolar membrane", "definition": "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuolar membrane. [GOC:TermGenie]"}
{"concept_id": "C3548164", "aliases": ["down-regulation of protein targeting to vacuolar membrane", "down regulation of protein targeting to vacuolar membrane", "downregulation of protein targeting to vacuolar membrane"], "types": ["T043"], "canonical_name": "negative regulation of protein targeting to vacuolar membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuolar membrane. [GOC:TermGenie]"}
{"concept_id": "C3548165", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein targeting to vacuolar membrane", "definition": "Any process that modulates the frequency, rate or extent of protein targeting to vacuolar membrane. [GOC:TermGenie]"}
{"concept_id": "C3548166", "aliases": ["negative regulation of diacylglycerol biosynthesis", "downregulation of diacylglycerol formation", "negative regulation of diacylglycerol anabolism", "down-regulation of diacylglycerol formation", "down regulation of diacylglycerol synthesis", "negative regulation of diacylglycerol synthesis", "down-regulation of diacylglycerol synthesis", "downregulation of diacylglycerol anabolism", "down-regulation of diacylglycerol biosynthesis", "down-regulation of diacylglycerol biosynthetic process", "inhibition of diacylglycerol anabolism", "inhibition of diacylglycerol formation", "downregulation of diacylglycerol biosynthesis", "down-regulation of diacylglycerol anabolism", "down regulation of diacylglycerol formation", "down regulation of diacylglycerol biosynthetic process", "downregulation of diacylglycerol synthesis", "down regulation of diacylglycerol biosynthesis", "inhibition of diacylglycerol synthesis", "down regulation of diacylglycerol anabolism", "inhibition of diacylglycerol biosynthesis", "negative regulation of diacylglycerol formation", "downregulation of diacylglycerol biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of diacylglycerol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3548167", "aliases": ["regulation of diacylglycerol synthesis", "regulation of diacylglycerol formation", "regulation of diacylglycerol biosynthesis", "regulation of diacylglycerol anabolism"], "types": ["T044"], "canonical_name": "regulation of diacylglycerol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of diacylglycerol biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3548168", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of flocculation via cell wall protein-carbohydrate interaction"}
{"concept_id": "C3548169", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of G1/S transition of mitotic cell cycle by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:dgf, GOC:TermGenie, PMID:19841732]"}
{"concept_id": "C3548175", "aliases": ["upregulation of phosphatidylserine biosynthetic process", "upregulation of phosphatidylserine formation", "upregulation of phosphatidylserine synthesis", "positive regulation of phosphatidylserine biosynthesis", "upregulation of phosphatidylserine anabolism", "positive regulation of phosphatidylserine anabolism", "up regulation of phosphatidylserine anabolism", "positive regulation of phosphatidylserine formation", "activation of phosphatidylserine formation", "up regulation of phosphatidylserine synthesis", "upregulation of phosphatidylserine biosynthesis", "up regulation of phosphatidylserine formation", "up-regulation of phosphatidylserine biosynthesis", "up regulation of phosphatidylserine biosynthetic process", "activation of phosphatidylserine biosynthesis", "positive regulation of phosphatidylserine synthesis", "activation of phosphatidylserine synthesis", "up-regulation of phosphatidylserine biosynthetic process", "activation of phosphatidylserine anabolism", "up-regulation of phosphatidylserine anabolism", "up-regulation of phosphatidylserine formation", "up regulation of phosphatidylserine biosynthesis", "up-regulation of phosphatidylserine synthesis"], "types": ["T044"], "canonical_name": "positive regulation of phosphatidylserine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process. [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]"}
{"concept_id": "C3548176", "aliases": ["down-regulation of phosphatidylserine formation", "negative regulation of phosphatidylserine anabolism", "downregulation of phosphatidylserine synthesis", "down regulation of phosphatidylserine biosynthesis", "down regulation of phosphatidylserine biosynthetic process", "down regulation of phosphatidylserine synthesis", "inhibition of phosphatidylserine anabolism", "down-regulation of phosphatidylserine biosynthesis", "down-regulation of phosphatidylserine biosynthetic process", "down-regulation of phosphatidylserine anabolism", "down regulation of phosphatidylserine anabolism", "negative regulation of phosphatidylserine formation", "negative regulation of phosphatidylserine biosynthesis", "negative regulation of phosphatidylserine synthesis", "downregulation of phosphatidylserine biosynthetic process", "inhibition of phosphatidylserine biosynthesis", "downregulation of phosphatidylserine formation", "inhibition of phosphatidylserine synthesis", "inhibition of phosphatidylserine formation", "down-regulation of phosphatidylserine synthesis", "downregulation of phosphatidylserine biosynthesis", "down regulation of phosphatidylserine formation", "downregulation of phosphatidylserine anabolism"], "types": ["T044"], "canonical_name": "negative regulation of phosphatidylserine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process. [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]"}
{"concept_id": "C3548177", "aliases": ["regulation of phosphatidylserine formation", "regulation of phosphatidylserine synthesis", "regulation of phosphatidylserine anabolism", "regulation of phosphatidylserine biosynthesis"], "types": ["T044"], "canonical_name": "regulation of phosphatidylserine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylserine biosynthetic process. [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]"}
{"concept_id": "C3548180", "aliases": ["negative regulation of cellular response to hyperosmotic salt stress by negative regulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular hyperosmotic salinity response by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:dgf, GOC:TermGenie, PMID:16278455]"}
{"concept_id": "C3548181", "aliases": ["negative regulation of cellular response to alkalinity by negative regulation of transcription from RNA polymerase II promoter", "negative regulation of cellular response to basic pH by negative regulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of cellular response to alkaline pH by negative regulation of transcription from RNA polymerase II promoter", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular response to alkalinity by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]"}
{"concept_id": "C3548183", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter", "definition": "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:dgf, GOC:TermGenie, PMID:11046133, PMID:8710886, PMID:9987114]"}
{"concept_id": "C3548185", "aliases": ["up-regulation of brassinosteroid mediated signalling", "up-regulation of brassinosteroid mediated signaling pathway", "positive regulation of brassinosteroid mediated signalling", "upregulation of brassinosteroid mediated signaling pathway", "activation of brassinosteroid mediated signalling", "upregulation of brassinosteroid mediated signalling", "up regulation of brassinosteroid mediated signalling", "up regulation of brassinosteroid mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of brassinosteroid mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of brassinosteroid mediated signaling pathway. [GOC:TermGenie, PMID:21855796]"}
{"concept_id": "C3548186", "aliases": ["downregulation of brassinosteroid mediated signaling pathway", "down-regulation of brassinosteroid mediated signaling pathway", "down regulation of brassinosteroid mediated signaling pathway", "negative regulation of brassinosteroid mediated signalling", "inhibition of brassinosteroid mediated signalling", "down regulation of brassinosteroid mediated signalling", "downregulation of brassinosteroid mediated signalling", "down-regulation of brassinosteroid mediated signalling"], "types": ["T044"], "canonical_name": "negative regulation of brassinosteroid mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of brassinosteroid mediated signaling pathway. [GOC:TermGenie, PMID:21855796]"}
{"concept_id": "C3548187", "aliases": ["regulation of brassinosteroid mediated signalling"], "types": ["T044"], "canonical_name": "regulation of brassinosteroid mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of brassinosteroid mediated signaling pathway. [GOC:TermGenie, PMID:21855796]"}
{"concept_id": "C3548189", "aliases": ["up-regulation of long term synaptic depression", "up regulation of long term synaptic depression", "upregulation of long term synaptic depression", "positive regulation of long term synaptic depression"], "types": ["T039"], "canonical_name": "positive regulation of long-term synaptic depression", "definition": "Any process that activates or increases the frequency, rate or extent of long term synaptic depression. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548190", "aliases": ["negative regulation of long term synaptic depression", "down regulation of long term synaptic depression", "downregulation of long term synaptic depression", "down-regulation of long term synaptic depression"], "types": ["T038"], "canonical_name": "negative regulation of long-term synaptic depression", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548191", "aliases": ["up regulation of glutamate signaling pathway", "upregulation of glutamate signalling pathway", "up-regulation of glutamate signalling pathway", "up regulation of glutamate signalling pathway", "up regulation of glutamate receptor signaling pathway", "activation of glutamate signalling pathway", "positive regulation of glutamate signaling pathway", "activation of glutamate signaling pathway", "positive regulation of glutamate signalling pathway", "upregulation of glutamate receptor signaling pathway", "upregulation of glutamate signaling pathway", "up-regulation of glutamate signaling pathway", "up-regulation of glutamate receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of glutamate receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548192", "aliases": ["down-regulation of glutamate receptor signaling pathway", "downregulation of glutamate signalling pathway", "negative regulation of glutamate signaling pathway", "inhibition of glutamate signaling pathway", "negative regulation of glutamate signalling pathway", "inhibition of glutamate signalling pathway", "down regulation of glutamate signaling pathway", "downregulation of glutamate signaling pathway", "down-regulation of glutamate signalling pathway", "downregulation of glutamate receptor signaling pathway", "down-regulation of glutamate signaling pathway", "down regulation of glutamate receptor signaling pathway", "down regulation of glutamate signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of glutamate receptor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548193", "aliases": ["regulation of glutamate signaling pathway", "regulation of glutamate signalling pathway"], "types": ["T044"], "canonical_name": "regulation of glutamate receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548195", "aliases": ["regulation of cell morphogenesis of phenotypic switching"], "types": ["T038"], "canonical_name": "regulation of cell morphogenesis involved in phenotypic switching", "definition": "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing a phenotypic switch. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells, such as the opaque cells of C. albicans, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548197", "aliases": ["up-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus", "upregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus", "up regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"], "types": ["T040"], "canonical_name": "positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus", "definition": "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548198", "aliases": ["down-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus", "down regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus", "downregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"], "types": ["T040"], "canonical_name": "negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548199", "aliases": [], "types": ["T039"], "canonical_name": "regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus", "definition": "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548200", "aliases": ["upregulation of filamentous growth of a population of unicellular organisms in response to neutral pH", "up-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH", "up regulation of filamentous growth of a population of unicellular organisms in response to neutral pH"], "types": ["T040"], "canonical_name": "positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH", "definition": "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548201", "aliases": ["down regulation of filamentous growth of a population of unicellular organisms in response to neutral pH", "downregulation of filamentous growth of a population of unicellular organisms in response to neutral pH", "down-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH"], "types": ["T040"], "canonical_name": "negative regulation of filamentous growth of a population of unicellular organisms in response to neutral pH", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548202", "aliases": [], "types": ["T039"], "canonical_name": "regulation of filamentous growth of a population of unicellular organisms in response to neutral pH", "definition": "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548203", "aliases": ["upregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus", "up regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus", "up-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus"], "types": ["T040"], "canonical_name": "positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus", "definition": "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548204", "aliases": ["down-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus", "downregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus", "down regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus"], "types": ["T040"], "canonical_name": "negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548205", "aliases": [], "types": ["T039"], "canonical_name": "regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus", "definition": "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548206", "aliases": ["up-regulation of filamentous growth of a population of unicellular organisms in response to starvation", "upregulation of filamentous growth of a population of unicellular organisms in response to starvation", "up regulation of filamentous growth of a population of unicellular organisms in response to starvation"], "types": ["T040"], "canonical_name": "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation", "definition": "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548208", "aliases": [], "types": ["T039"], "canonical_name": "regulation of filamentous growth of a population of unicellular organisms in response to starvation", "definition": "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548209", "aliases": ["up regulation of filamentous growth of a population of unicellular organisms in response to heat", "upregulation of filamentous growth of a population of unicellular organisms in response to heat", "up-regulation of filamentous growth of a population of unicellular organisms in response to heat"], "types": ["T040"], "canonical_name": "positive regulation of filamentous growth of a population of unicellular organisms in response to heat", "definition": "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548210", "aliases": ["downregulation of filamentous growth of a population of unicellular organisms in response to heat", "down-regulation of filamentous growth of a population of unicellular organisms in response to heat", "down regulation of filamentous growth of a population of unicellular organisms in response to heat"], "types": ["T040"], "canonical_name": "negative regulation of filamentous growth of a population of unicellular organisms in response to heat", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548211", "aliases": [], "types": ["T039"], "canonical_name": "regulation of filamentous growth of a population of unicellular organisms in response to heat", "definition": "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548212", "aliases": ["up regulation of filamentous growth of a population of unicellular organisms", "upregulation of filamentous growth of a population of unicellular organisms", "up-regulation of filamentous growth of a population of unicellular organisms"], "types": ["T040"], "canonical_name": "positive regulation of filamentous growth of a population of unicellular organisms", "definition": "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548213", "aliases": ["down-regulation of filamentous growth of a population of unicellular organisms", "down regulation of filamentous growth of a population of unicellular organisms", "downregulation of filamentous growth of a population of unicellular organisms"], "types": ["T040"], "canonical_name": "negative regulation of filamentous growth of a population of unicellular organisms", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548214", "aliases": [], "types": ["T040"], "canonical_name": "regulation of filamentous growth of a population of unicellular organisms", "definition": "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548216", "aliases": ["up regulation of defence response to bacteria", "up regulation of defense response to bacteria", "up regulation of defence response to bacterium", "positive regulation of defense response to bacteria", "up-regulation of defence response to bacterium", "upregulation of defence response to bacterium", "up-regulation of defence response to bacteria", "upregulation of defense response to bacteria", "up regulation of defense response to bacterium", "positive regulation of defence response to bacteria", "positive regulation of defence response to bacterium", "upregulation of defence response to bacteria", "up-regulation of defense response to bacterium", "activation of defence response to bacteria", "upregulation of defense response to bacterium", "activation of defence response to bacterium", "activation of defense response to bacterium", "activation of defense response to bacteria", "up-regulation of defense response to bacteria"], "types": ["T040"], "canonical_name": "positive regulation of defense response to bacterium", "definition": "Any process that activates or increases the frequency, rate or extent of defense response to bacterium. [GOC:TermGenie, PMID:22346749]"}
{"concept_id": "C3548217", "aliases": ["down regulation of defence response to bacterium", "down-regulation of defense response to bacterium", "downregulation of defence response to bacteria", "down-regulation of defence response to bacterium", "negative regulation of defense response to bacteria", "downregulation of defense response to bacteria", "down-regulation of defense response to bacteria", "downregulation of defence response to bacterium", "down regulation of defense response to bacteria", "down regulation of defence response to bacteria", "downregulation of defense response to bacterium", "down regulation of defense response to bacterium", "down-regulation of defence response to bacteria", "negative regulation of defence response to bacterium", "inhibition of defence response to bacterium", "negative regulation of defence response to bacteria", "inhibition of defence response to bacteria", "inhibition of defense response to bacterium", "inhibition of defense response to bacteria"], "types": ["T038"], "canonical_name": "negative regulation of defense response to bacterium", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. [GOC:TermGenie, PMID:22346749]"}
{"concept_id": "C3548218", "aliases": ["regulation of defence response to bacterium", "regulation of defence response to bacteria", "regulation of defense response to bacteria"], "types": ["T039"], "canonical_name": "regulation of defense response to bacterium", "definition": "Any process that modulates the frequency, rate or extent of defense response to bacterium. [GOC:TermGenie, PMID:22346749]"}
{"concept_id": "C3548219", "aliases": ["up-regulation of cellular alcohol catabolic process", "up regulation of cellular alcohol catabolic process", "upregulation of cellular alcohol catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of cellular alcohol catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellular alcohol catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3548220", "aliases": ["down regulation of cellular alcohol catabolic process", "down-regulation of cellular alcohol catabolic process", "downregulation of cellular alcohol catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of cellular alcohol catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular alcohol catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3548221", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cellular alcohol catabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellular alcohol catabolic process. [GOC:TermGenie]"}
{"concept_id": "C3548230", "aliases": ["up-regulation of cellular response to oxidative stress", "upregulation of cellular response to oxidative stress", "up regulation of cellular response to oxidative stress"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to oxidative stress", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress. [GOC:mah, GOC:TermGenie]"}
{"concept_id": "C3548231", "aliases": ["downregulation of cellular response to oxidative stress", "down regulation of cellular response to oxidative stress", "down-regulation of cellular response to oxidative stress"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to oxidative stress", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress. [GOC:mah, GOC:TermGenie]"}
{"concept_id": "C3548232", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to oxidative stress", "definition": "Any process that modulates the frequency, rate or extent of cellular response to oxidative stress. [GOC:mah, GOC:TermGenie]"}
{"concept_id": "C3548237", "aliases": [], "types": ["T045"], "canonical_name": "regulation of meiosis by regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C3548238", "aliases": ["regulation of iron import by regulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of iron ion import by regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C3548239", "aliases": ["downregulation of pyrimidine nucleotide anabolism", "inhibition of pyrimidine nucleotide synthesis", "down-regulation of pyrimidine nucleotide anabolism", "downregulation of pyrimidine nucleotide synthesis", "inhibition of pyrimidine nucleotide biosynthesis", "down regulation of pyrimidine nucleotide formation", "down-regulation of pyrimidine nucleotide formation", "down-regulation of pyrimidine nucleotide biosynthesis", "downregulation of pyrimidine nucleotide biosynthetic process", "down regulation of pyrimidine nucleotide biosynthetic process", "down regulation of pyrimidine nucleotide synthesis", "downregulation of pyrimidine nucleotide biosynthesis", "inhibition of pyrimidine nucleotide formation", "negative regulation of pyrimidine nucleotide synthesis", "down-regulation of pyrimidine nucleotide synthesis", "downregulation of pyrimidine nucleotide formation", "negative regulation of pyrimidine nucleotide anabolism", "negative regulation of pyrimidine nucleotide formation", "negative regulation of pyrimidine nucleotide biosynthesis", "down regulation of pyrimidine nucleotide anabolism", "down regulation of pyrimidine nucleotide biosynthesis", "inhibition of pyrimidine nucleotide anabolism", "down-regulation of pyrimidine nucleotide biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of pyrimidine nucleotide biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pyrimidine nucleotide biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3548240", "aliases": ["regulation of pyrimidine nucleotide biosynthesis", "regulation of pyrimidine nucleotide anabolism", "regulation of pyrimidine nucleotide synthesis", "regulation of pyrimidine nucleotide formation"], "types": ["T044"], "canonical_name": "regulation of pyrimidine nucleotide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3548241", "aliases": ["down regulation of kojic acid biosynthesis", "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "down regulation of kojic acid biosynthetic process", "down regulation of kojic acid formation", "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "downregulation of kojic acid formation", "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "down-regulation of kojic acid formation", "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "downregulation of kojic acid biosynthetic process", "negative regulation of kojic acid formation", "negative regulation of kojic acid synthesis", "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "down regulation of kojic acid anabolism", "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "down-regulation of kojic acid biosynthesis", "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "negative regulation of kojic acid biosynthesis", "down regulation of kojic acid synthesis", "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "down-regulation of kojic acid anabolism", "inhibition of kojic acid synthesis", "down-regulation of kojic acid biosynthetic process", "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "inhibition of kojic acid biosynthesis", "downregulation of kojic acid synthesis", "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "downregulation of kojic acid anabolism", "inhibition of kojic acid anabolism", "inhibition of kojic acid formation", "down-regulation of kojic acid synthesis", "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "downregulation of kojic acid biosynthesis", "negative regulation of kojic acid anabolism"], "types": ["T044"], "canonical_name": "negative regulation of kojic acid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of kojic acid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548242", "aliases": ["regulation of kojic acid anabolism", "regulation of kojic acid synthesis", "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process", "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis", "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation", "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism", "regulation of kojic acid biosynthesis", "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis", "regulation of kojic acid formation"], "types": ["T044"], "canonical_name": "regulation of kojic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of kojic acid biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548243", "aliases": [], "types": ["T045"], "canonical_name": "regulation of iron ion transport by regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C3548246", "aliases": ["regulation of iron ion import"], "types": ["T043"], "canonical_name": "regulation of iron import"}
{"concept_id": "C3548250", "aliases": ["downregulation of flavonol biosynthetic process", "down-regulation of flavonol biosynthetic process", "down regulation of flavonol biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of flavonol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of flavonol biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3548251", "aliases": [], "types": ["T044"], "canonical_name": "regulation of flavonol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of flavonol biosynthetic process. [GOC:TermGenie]"}
{"concept_id": "C3548252", "aliases": ["regulation of synaptic plasticity by receptor localisation to synapse"], "types": ["T043"], "canonical_name": "regulation of synaptic plasticity by receptor localization to synapse", "definition": "Any process that modulates synaptic plasticity, the ability of synapses to change as circumstances require, via receptor localization to the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. Processes may include receptor transport to, and/or maintenance at, the synapse. [GOC:kmv, GOC:TermGenie, PMID:22464329]"}
{"concept_id": "C3548254", "aliases": ["negative regulation of asperthecin synthesis", "down regulation of asperthecin biosynthesis", "down regulation of asperthecin formation", "down-regulation of asperthecin synthesis", "downregulation of asperthecin synthesis", "negative regulation of asperthecin biosynthesis", "down-regulation of asperthecin biosynthesis", "inhibition of asperthecin synthesis", "down regulation of asperthecin synthesis", "downregulation of asperthecin formation", "down-regulation of asperthecin formation", "down-regulation of asperthecin biosynthetic process", "inhibition of asperthecin formation", "inhibition of asperthecin biosynthesis", "downregulation of asperthecin biosynthetic process", "down regulation of asperthecin biosynthetic process", "negative regulation of asperthecin formation", "downregulation of asperthecin biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of asperthecin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of asperthecin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548255", "aliases": ["regulation of asperthecin formation", "regulation of asperthecin synthesis", "regulation of asperthecin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of asperthecin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of asperthecin biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548256", "aliases": ["inhibition of secondary metabolite biosynthesis", "negative regulation of secondary metabolite biosynthesis", "down-regulation of secondary metabolite biosynthetic process", "down regulation of secondary metabolite biosynthesis", "down-regulation of secondary metabolite biosynthesis", "down regulation of secondary metabolite biosynthetic process", "downregulation of secondary metabolite biosynthetic process", "downregulation of secondary metabolite biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of secondary metabolite biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548257", "aliases": ["regulation of secondary metabolite biosynthesis"], "types": ["T044"], "canonical_name": "regulation of secondary metabolite biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process. [GOC:di, GOC:TermGenie]"}
{"concept_id": "C3548260", "aliases": ["positive regulation of purine nucleotide formation", "up-regulation of purine nucleotide anabolism", "up-regulation of purine nucleotide biosynthesis", "up-regulation of purine nucleotide biosynthetic process", "activation of purine nucleotide formation", "upregulation of purine nucleotide formation", "positive regulation of purine nucleotide anabolism", "up-regulation of purine nucleotide formation", "up-regulation of purine nucleotide synthesis", "upregulation of purine nucleotide biosynthesis", "activation of purine nucleotide synthesis", "up regulation of purine nucleotide anabolism", "activation of purine nucleotide anabolism", "upregulation of purine nucleotide synthesis", "up regulation of purine nucleotide synthesis", "positive regulation of purine nucleotide biosynthesis", "activation of purine nucleotide biosynthesis", "up regulation of purine nucleotide formation", "positive regulation of purine nucleotide synthesis", "upregulation of purine nucleotide biosynthetic process", "upregulation of purine nucleotide anabolism", "up regulation of purine nucleotide biosynthesis", "up regulation of purine nucleotide biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of purine nucleotide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes. [GOC:go_curators, GOC:TermGenie]"}
{"concept_id": "C3548261", "aliases": ["down regulation of purine nucleotide biosynthetic process", "negative regulation of purine nucleotide biosynthesis", "downregulation of purine nucleotide anabolism", "down-regulation of purine nucleotide biosynthetic process", "negative regulation of purine nucleotide anabolism", "down regulation of purine nucleotide synthesis", "negative regulation of purine nucleotide synthesis", "down-regulation of purine nucleotide anabolism", "downregulation of purine nucleotide biosynthesis", "down-regulation of purine nucleotide formation", "inhibition of purine nucleotide biosynthesis", "downregulation of purine nucleotide synthesis", "down regulation of purine nucleotide anabolism", "downregulation of purine nucleotide biosynthetic process", "downregulation of purine nucleotide formation", "down regulation of purine nucleotide biosynthesis", "inhibition of purine nucleotide formation", "down regulation of purine nucleotide formation", "inhibition of purine nucleotide anabolism", "down-regulation of purine nucleotide synthesis", "negative regulation of purine nucleotide formation", "inhibition of purine nucleotide synthesis", "down-regulation of purine nucleotide biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of purine nucleotide biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes. [GOC:go_curators, GOC:TermGenie]"}
{"concept_id": "C3548262", "aliases": ["regulation of purine nucleotide biosynthesis", "regulation of purine nucleotide formation", "regulation of purine nucleotide synthesis", "regulation of purine nucleotide anabolism"], "types": ["T044"], "canonical_name": "regulation of purine nucleotide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes. [GOC:go_curators, GOC:TermGenie]"}
{"concept_id": "C3548263", "aliases": ["up regulation of RNAi", "up regulation of RNA interference", "up-regulation of RNAi", "up-regulation of RNA interference", "positive regulation of RNAi", "positive regulation of RNA interference", "activation of RNAi", "upregulation of RNA interference", "upregulation of RNAi", "positive regulation of PTGS"], "types": ["T045"], "canonical_name": "positive regulation of post-transcriptional gene silencing by RNA", "definition": "Any process that activates or increases the frequency, rate or extent of post-transcriptional gene silencing by RNA. [GOC:kmv, GOC:TermGenie, PMID:22412382]"}
{"concept_id": "C3548264", "aliases": ["negative regulation of PTGS", "downregulation of RNA interference", "negative regulation of posttranscriptional gene silencing by siRNA", "down regulation of RNAi", "downregulation of RNAi", "down regulation of RNA interference", "down-regulation of RNAi", "negative regulation of RNAi", "negative regulation of RNA interference", "inhibition of RNAi", "down-regulation of RNA interference"], "types": ["T043"], "canonical_name": "negative regulation of post-transcriptional gene silencing by RNA", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA. [GOC:kmv, GOC:TermGenie, PMID:22412382]"}
{"concept_id": "C3548265", "aliases": ["regulation of PTGS", "regulation of RNA interference", "regulation of RNAi"], "types": ["T045"], "canonical_name": "regulation of post-transcriptional gene silencing by RNA", "definition": "Any process that modulates the frequency, rate or extent of post-transcriptional gene silencing by RNA. [GOC:kmv, GOC:TermGenie, PMID:22412382]"}
{"concept_id": "C3548266", "aliases": ["up regulation of defense response to insect", "upregulation of physiological defense response to insect", "positive regulation of physiological defense response to insect", "upregulation of defense response to insect", "up-regulation of defense response to insect", "up-regulation of physiological defense response to insect", "up regulation of physiological defense response to insect"], "types": ["T040"], "canonical_name": "positive regulation of defense response to insect", "definition": "Any process that activates or increases the frequency, rate or extent of defense response to insect. [GOC:TermGenie, PMID:22474183]"}
{"concept_id": "C3548267", "aliases": ["down-regulation of physiological defense response to insect", "negative regulation of physiological defense response to insect", "down-regulation of defense response to insect", "down regulation of defense response to insect", "downregulation of physiological defense response to insect", "downregulation of defense response to insect", "down regulation of physiological defense response to insect"], "types": ["T040"], "canonical_name": "negative regulation of defense response to insect", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect. [GOC:TermGenie, PMID:22474183]"}
{"concept_id": "C3548268", "aliases": ["up regulation of mRNA polyadenylylation", "up-regulation of mRNA polyadenylylation", "up regulation of mRNA polyadenylation", "upregulation of mRNA polyadenylation", "up-regulation of mRNA polyadenylation", "upregulation of mRNA polyadenylylation", "positive regulation of mRNA polyadenylylation"], "types": ["T045"], "canonical_name": "positive regulation of mRNA polyadenylation", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA polyadenylation. [GOC:se, GOC:TermGenie, PMID:15121841]"}
{"concept_id": "C3548269", "aliases": ["down regulation of mRNA polyadenylation", "down regulation of mRNA polyadenylylation", "down-regulation of mRNA polyadenylation", "negative regulation of mRNA polyadenylylation", "down-regulation of mRNA polyadenylylation", "downregulation of mRNA polyadenylylation", "downregulation of mRNA polyadenylation"], "types": ["T045"], "canonical_name": "negative regulation of mRNA polyadenylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation. [GOC:se, GOC:TermGenie, PMID:15121841]"}
{"concept_id": "C3548270", "aliases": ["regulation of mRNA polyadenylylation"], "types": ["T045"], "canonical_name": "regulation of mRNA polyadenylation", "definition": "Any process that modulates the frequency, rate or extent of mRNA polyadenylation. [GOC:se, GOC:TermGenie, PMID:15121841]"}
{"concept_id": "C3548271", "aliases": ["upregulation of pentasaccharide transport", "up regulation of pentasaccharide transport", "up-regulation of pentasaccharide transport"], "types": ["T044"], "canonical_name": "positive regulation of pentasaccharide transport", "definition": "Any process that activates or increases the frequency, rate or extent of pentasaccharide transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548272", "aliases": ["downregulation of pentasaccharide transport", "down regulation of pentasaccharide transport", "down-regulation of pentasaccharide transport"], "types": ["T043"], "canonical_name": "negative regulation of pentasaccharide transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pentasaccharide transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548273", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pentasaccharide transport", "definition": "Any process that modulates the frequency, rate or extent of pentasaccharide transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548274", "aliases": ["up-regulation of nigerotriose transport", "upregulation of nigerotriose transport", "up regulation of nigerotriose transport"], "types": ["T044"], "canonical_name": "positive regulation of nigerotriose transport", "definition": "Any process that activates or increases the frequency, rate or extent of nigerotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548275", "aliases": ["down regulation of nigerotriose transport", "downregulation of nigerotriose transport", "down-regulation of nigerotriose transport"], "types": ["T043"], "canonical_name": "negative regulation of nigerotriose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nigerotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548276", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nigerotriose transport", "definition": "Any process that modulates the frequency, rate or extent of nigerotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548277", "aliases": ["upregulation of methanofuran metabolic process", "upregulation of methanofuran metabolism", "positive regulation of methanofuran metabolism", "up regulation of methanofuran metabolism", "up-regulation of methanofuran metabolism", "up regulation of methanofuran metabolic process", "up-regulation of methanofuran metabolic process", "activation of methanofuran metabolism"], "types": ["T044"], "canonical_name": "positive regulation of methanofuran metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of methanofuran metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548278", "aliases": ["down-regulation of methanofuran metabolic process", "downregulation of methanofuran metabolic process", "negative regulation of methanofuran metabolism", "inhibition of methanofuran metabolism", "down regulation of methanofuran metabolic process", "down regulation of methanofuran metabolism", "downregulation of methanofuran metabolism", "down-regulation of methanofuran metabolism"], "types": ["T044"], "canonical_name": "negative regulation of methanofuran metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548279", "aliases": ["regulation of methanofuran metabolism"], "types": ["T044"], "canonical_name": "regulation of methanofuran metabolic process", "definition": "Any process that modulates the frequency, rate or extent of methanofuran metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548280", "aliases": ["up-regulation of methanofuran biosynthetic process", "upregulation of methanofuran biosynthesis", "upregulation of methanofuran biosynthetic process", "up regulation of methanofuran biosynthetic process", "positive regulation of methanofuran biosynthesis", "up regulation of methanofuran biosynthesis", "up-regulation of methanofuran biosynthesis", "activation of methanofuran biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of methanofuran biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of methanofuran biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548281", "aliases": ["downregulation of methanofuran biosynthesis", "negative regulation of methanofuran biosynthesis", "down regulation of methanofuran biosynthesis", "inhibition of methanofuran biosynthesis", "down regulation of methanofuran biosynthetic process", "down-regulation of methanofuran biosynthesis", "downregulation of methanofuran biosynthetic process", "down-regulation of methanofuran biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of methanofuran biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548282", "aliases": ["regulation of methanofuran biosynthesis"], "types": ["T044"], "canonical_name": "regulation of methanofuran biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of methanofuran biosynthetic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548283", "aliases": ["up-regulation of methane biosynthetic process from methylamine", "upregulation of methane biosynthetic process from methylamine", "up regulation of methane biosynthetic process from methylamine"], "types": ["T044"], "canonical_name": "positive regulation of methane biosynthetic process from methylamine", "definition": "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methylamine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548284", "aliases": ["down-regulation of methane biosynthetic process from methylamine", "down regulation of methane biosynthetic process from methylamine", "downregulation of methane biosynthetic process from methylamine"], "types": ["T044"], "canonical_name": "negative regulation of methane biosynthetic process from methylamine", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methylamine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548285", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methane biosynthetic process from methylamine", "definition": "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methylamine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548286", "aliases": ["up regulation of methane biosynthetic process from methanethiol", "up-regulation of methane biosynthetic process from methanethiol", "upregulation of methane biosynthetic process from methanethiol"], "types": ["T044"], "canonical_name": "positive regulation of methane biosynthetic process from methanethiol", "definition": "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methanethiol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548287", "aliases": ["down-regulation of methane biosynthetic process from methanethiol", "down regulation of methane biosynthetic process from methanethiol", "downregulation of methane biosynthetic process from methanethiol"], "types": ["T044"], "canonical_name": "negative regulation of methane biosynthetic process from methanethiol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methanethiol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548288", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methane biosynthetic process from methanethiol", "definition": "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methanethiol. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548289", "aliases": ["up regulation of methane biosynthetic process from dimethyl sulfide", "upregulation of methane biosynthetic process from dimethyl sulfide", "up-regulation of methane biosynthetic process from dimethyl sulfide"], "types": ["T044"], "canonical_name": "positive regulation of methane biosynthetic process from dimethyl sulfide", "definition": "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548290", "aliases": ["downregulation of methane biosynthetic process from dimethyl sulfide", "down-regulation of methane biosynthetic process from dimethyl sulfide", "down regulation of methane biosynthetic process from dimethyl sulfide"], "types": ["T044"], "canonical_name": "negative regulation of methane biosynthetic process from dimethyl sulfide", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548291", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methane biosynthetic process from dimethyl sulfide", "definition": "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548292", "aliases": ["up regulation of methane biosynthetic process from formic acid", "up-regulation of methane biosynthetic process from formic acid", "upregulation of methane biosynthetic process from formic acid"], "types": ["T040"], "canonical_name": "positive regulation of methane biosynthetic process from formic acid", "definition": "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from formic acid. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548293", "aliases": ["downregulation of methane biosynthetic process from formic acid", "down regulation of methane biosynthetic process from formic acid", "down-regulation of methane biosynthetic process from formic acid"], "types": ["T044"], "canonical_name": "negative regulation of methane biosynthetic process from formic acid", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from formic acid. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548294", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methane biosynthetic process from formic acid", "definition": "Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548295", "aliases": ["upregulation of methane biosynthetic process from carbon monoxide", "up regulation of methane biosynthetic process from carbon monoxide", "up-regulation of methane biosynthetic process from carbon monoxide"], "types": ["T043"], "canonical_name": "positive regulation of methane biosynthetic process from carbon monoxide", "definition": "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from carbon monoxide. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548296", "aliases": ["downregulation of methane biosynthetic process from carbon monoxide", "down regulation of methane biosynthetic process from carbon monoxide", "down-regulation of methane biosynthetic process from carbon monoxide"], "types": ["T044"], "canonical_name": "negative regulation of methane biosynthetic process from carbon monoxide", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from carbon monoxide. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548297", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methane biosynthetic process from carbon monoxide", "definition": "Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548298", "aliases": ["up-regulation of methane biosynthetic process from 3-(methylthio)propionic acid", "up regulation of methane biosynthetic process from 3-(methylthio)propionic acid", "upregulation of methane biosynthetic process from 3-(methylthio)propionic acid"], "types": ["T043"], "canonical_name": "positive regulation of methane biosynthetic process from 3-(methylthio)propionic acid", "definition": "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548299", "aliases": ["down-regulation of methane biosynthetic process from 3-(methylthio)propionic acid", "down regulation of methane biosynthetic process from 3-(methylthio)propionic acid", "downregulation of methane biosynthetic process from 3-(methylthio)propionic acid"], "types": ["T044"], "canonical_name": "negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548300", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methane biosynthetic process from 3-(methylthio)propionic acid", "definition": "Any process that modulates the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548301", "aliases": ["upregulation of methane biosynthetic process from trimethylamine", "up regulation of methane biosynthetic process from trimethylamine", "up-regulation of methane biosynthetic process from trimethylamine"], "types": ["T044"], "canonical_name": "positive regulation of methane biosynthetic process from trimethylamine", "definition": "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from trimethylamine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548302", "aliases": ["down regulation of methane biosynthetic process from trimethylamine", "downregulation of methane biosynthetic process from trimethylamine", "down-regulation of methane biosynthetic process from trimethylamine"], "types": ["T044"], "canonical_name": "negative regulation of methane biosynthetic process from trimethylamine", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from trimethylamine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548303", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methane biosynthetic process from trimethylamine", "definition": "Any process that modulates the frequency, rate or extent of methane biosynthetic process from trimethylamine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548304", "aliases": ["upregulation of mannotriose transport", "up regulation of mannotriose transport", "up-regulation of mannotriose transport"], "types": ["T044"], "canonical_name": "positive regulation of mannotriose transport", "definition": "Any process that activates or increases the frequency, rate or extent of mannotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548305", "aliases": ["downregulation of mannotriose transport", "down regulation of mannotriose transport", "down-regulation of mannotriose transport"], "types": ["T043"], "canonical_name": "negative regulation of mannotriose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mannotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548306", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mannotriose transport", "definition": "Any process that modulates the frequency, rate or extent of mannotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548307", "aliases": ["upregulation of maltotriulose transport", "up-regulation of maltotriulose transport", "up regulation of maltotriulose transport"], "types": ["T044"], "canonical_name": "positive regulation of maltotriulose transport", "definition": "Any process that activates or increases the frequency, rate or extent of maltotriulose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548308", "aliases": ["downregulation of maltotriulose transport", "down-regulation of maltotriulose transport", "down regulation of maltotriulose transport"], "types": ["T043"], "canonical_name": "negative regulation of maltotriulose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maltotriulose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548309", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maltotriulose transport", "definition": "Any process that modulates the frequency, rate or extent of maltotriulose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548310", "aliases": ["up-regulation of maltotetraose transport", "up regulation of maltotetraose transport", "upregulation of maltotetraose transport"], "types": ["T044"], "canonical_name": "positive regulation of maltotetraose transport", "definition": "Any process that activates or increases the frequency, rate or extent of maltotetraose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548311", "aliases": ["downregulation of maltotetraose transport", "down regulation of maltotetraose transport", "down-regulation of maltotetraose transport"], "types": ["T043"], "canonical_name": "negative regulation of maltotetraose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maltotetraose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548312", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maltotetraose transport", "definition": "Any process that modulates the frequency, rate or extent of maltotetraose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548313", "aliases": ["up-regulation of methane biosynthetic process from dimethylamine", "upregulation of methane biosynthetic process from dimethylamine", "up regulation of methane biosynthetic process from dimethylamine"], "types": ["T044"], "canonical_name": "positive regulation of methane biosynthetic process from dimethylamine", "definition": "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethylamine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548314", "aliases": ["downregulation of methane biosynthetic process from dimethylamine", "down-regulation of methane biosynthetic process from dimethylamine", "down regulation of methane biosynthetic process from dimethylamine"], "types": ["T044"], "canonical_name": "negative regulation of methane biosynthetic process from dimethylamine", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethylamine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548315", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methane biosynthetic process from dimethylamine", "definition": "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethylamine. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548316", "aliases": ["upregulation of maltopentaose transport", "up-regulation of maltopentaose transport", "up regulation of maltopentaose transport"], "types": ["T044"], "canonical_name": "positive regulation of maltopentaose transport", "definition": "Any process that activates or increases the frequency, rate or extent of maltopentaose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548317", "aliases": ["down regulation of maltopentaose transport", "downregulation of maltopentaose transport", "down-regulation of maltopentaose transport"], "types": ["T043"], "canonical_name": "negative regulation of maltopentaose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maltopentaose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548318", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maltopentaose transport", "definition": "Any process that modulates the frequency, rate or extent of maltopentaose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548319", "aliases": ["up-regulation of maltohexaose transport", "up regulation of maltohexaose transport", "upregulation of maltohexaose transport"], "types": ["T044"], "canonical_name": "positive regulation of maltohexaose transport", "definition": "Any process that activates or increases the frequency, rate or extent of maltohexaose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548320", "aliases": ["down-regulation of maltohexaose transport", "down regulation of maltohexaose transport", "downregulation of maltohexaose transport"], "types": ["T043"], "canonical_name": "negative regulation of maltohexaose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maltohexaose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548321", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maltohexaose transport", "definition": "Any process that modulates the frequency, rate or extent of maltohexaose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548322", "aliases": ["up regulation of maltoheptaose metabolism", "upregulation of maltoheptaose metabolism", "positive regulation of maltoheptaose metabolism", "upregulation of maltoheptaose metabolic process", "up-regulation of maltoheptaose metabolic process", "up-regulation of maltoheptaose metabolism", "up regulation of maltoheptaose metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of maltoheptaose metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of maltoheptaose metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548323", "aliases": ["down regulation of maltoheptaose metabolism", "down regulation of maltoheptaose metabolic process", "down-regulation of maltoheptaose metabolic process", "downregulation of maltoheptaose metabolic process", "negative regulation of maltoheptaose metabolism", "down-regulation of maltoheptaose metabolism", "downregulation of maltoheptaose metabolism"], "types": ["T043"], "canonical_name": "negative regulation of maltoheptaose metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548324", "aliases": ["regulation of maltoheptaose metabolism"], "types": ["T044"], "canonical_name": "regulation of maltoheptaose metabolic process", "definition": "Any process that modulates the frequency, rate or extent of maltoheptaose metabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548325", "aliases": ["upregulation of maltoheptaose transport", "up regulation of maltoheptaose transport", "up-regulation of maltoheptaose transport"], "types": ["T044"], "canonical_name": "positive regulation of maltoheptaose transport", "definition": "Any process that activates or increases the frequency, rate or extent of maltoheptaose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548326", "aliases": ["down-regulation of maltoheptaose transport", "down regulation of maltoheptaose transport", "downregulation of maltoheptaose transport"], "types": ["T043"], "canonical_name": "negative regulation of maltoheptaose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548327", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maltoheptaose transport", "definition": "Any process that modulates the frequency, rate or extent of maltoheptaose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548328", "aliases": ["up regulation of laminaritriose transport", "up-regulation of laminaritriose transport", "upregulation of laminaritriose transport"], "types": ["T044"], "canonical_name": "positive regulation of laminaritriose transport", "definition": "Any process that activates or increases the frequency, rate or extent of laminaritriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548329", "aliases": ["down-regulation of laminaritriose transport", "downregulation of laminaritriose transport", "down regulation of laminaritriose transport"], "types": ["T043"], "canonical_name": "negative regulation of laminaritriose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of laminaritriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548330", "aliases": [], "types": ["T043"], "canonical_name": "regulation of laminaritriose transport", "definition": "Any process that modulates the frequency, rate or extent of laminaritriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548334", "aliases": ["upregulation of hexasaccharide transport", "up-regulation of hexasaccharide transport", "up regulation of hexasaccharide transport"], "types": ["T044"], "canonical_name": "positive regulation of hexasaccharide transport", "definition": "Any process that activates or increases the frequency, rate or extent of hexasaccharide transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548335", "aliases": ["down regulation of hexasaccharide transport", "downregulation of hexasaccharide transport", "down-regulation of hexasaccharide transport"], "types": ["T043"], "canonical_name": "negative regulation of hexasaccharide transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hexasaccharide transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548336", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hexasaccharide transport", "definition": "Any process that modulates the frequency, rate or extent of hexasaccharide transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548337", "aliases": ["up regulation of heptasaccharide transport", "upregulation of heptasaccharide transport", "up-regulation of heptasaccharide transport"], "types": ["T044"], "canonical_name": "positive regulation of heptasaccharide transport", "definition": "Any process that activates or increases the frequency, rate or extent of heptasaccharide transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548338", "aliases": ["down-regulation of heptasaccharide transport", "down regulation of heptasaccharide transport", "downregulation of heptasaccharide transport"], "types": ["T043"], "canonical_name": "negative regulation of heptasaccharide transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of heptasaccharide transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548339", "aliases": [], "types": ["T043"], "canonical_name": "regulation of heptasaccharide transport", "definition": "Any process that modulates the frequency, rate or extent of heptasaccharide transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548340", "aliases": ["up regulation of galactotriose transport", "up-regulation of galactotriose transport", "upregulation of galactotriose transport"], "types": ["T044"], "canonical_name": "positive regulation of galactotriose transport", "definition": "Any process that activates or increases the frequency, rate or extent of galactotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548341", "aliases": ["down regulation of galactotriose transport", "down-regulation of galactotriose transport", "downregulation of galactotriose transport"], "types": ["T043"], "canonical_name": "negative regulation of galactotriose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of galactotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548342", "aliases": [], "types": ["T043"], "canonical_name": "regulation of galactotriose transport", "definition": "Any process that modulates the frequency, rate or extent of galactotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548343", "aliases": ["positive regulation of coenzyme F420-dependent nitroimidazole reduction", "up regulation of coenzyme F420-dependent nitroimidazole reduction", "up regulation of coenzyme F420-dependent nitroimidazole catabolism", "up regulation of coenzyme F420-dependent nitroimidazole breakdown", "up regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process", "positive regulation of coenzyme F420-dependent nitroimidazole catabolism", "up-regulation of coenzyme F420-dependent nitroimidazole catabolism", "upregulation of coenzyme F420-dependent nitroimidazole breakdown", "positive regulation of coenzyme F420-dependent nitroimidazole breakdown", "upregulation of coenzyme F420-dependent nitroimidazole reduction", "up-regulation of coenzyme F420-dependent nitroimidazole reduction", "up-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process", "upregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process", "upregulation of coenzyme F420-dependent nitroimidazole catabolism", "up-regulation of coenzyme F420-dependent nitroimidazole breakdown"], "types": ["T044"], "canonical_name": "positive regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548344", "aliases": ["downregulation of coenzyme F420-dependent nitroimidazole breakdown", "down-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process", "down regulation of coenzyme F420-dependent nitroimidazole reduction", "downregulation of coenzyme F420-dependent nitroimidazole catabolism", "down-regulation of coenzyme F420-dependent nitroimidazole reduction", "downregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process", "negative regulation of coenzyme F420-dependent nitroimidazole breakdown", "down regulation of coenzyme F420-dependent nitroimidazole breakdown", "negative regulation of coenzyme F420-dependent nitroimidazole catabolism", "down-regulation of coenzyme F420-dependent nitroimidazole catabolism", "down-regulation of coenzyme F420-dependent nitroimidazole breakdown", "downregulation of coenzyme F420-dependent nitroimidazole reduction", "down regulation of coenzyme F420-dependent nitroimidazole catabolism", "negative regulation of coenzyme F420-dependent nitroimidazole reduction", "down regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548345", "aliases": ["regulation of coenzyme F420-dependent nitroimidazole catabolism", "regulation of coenzyme F420-dependent nitroimidazole breakdown", "regulation of coenzyme F420-dependent nitroimidazole reduction"], "types": ["T044"], "canonical_name": "regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process", "definition": "Any process that modulates the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548346", "aliases": ["upregulation of cellotriose transport", "up-regulation of cellotriose transport", "up regulation of cellotriose transport"], "types": ["T044"], "canonical_name": "positive regulation of cellotriose transport", "definition": "Any process that activates or increases the frequency, rate or extent of cellotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548347", "aliases": ["downregulation of cellotriose transport", "down-regulation of cellotriose transport", "down regulation of cellotriose transport"], "types": ["T043"], "canonical_name": "negative regulation of cellotriose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548348", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellotriose transport", "definition": "Any process that modulates the frequency, rate or extent of cellotriose transport. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548349", "aliases": ["upregulation of cellobiose catabolic process", "upregulation of cellobiose catabolism", "up-regulation of cellobiose catabolism", "up-regulation of cellobiose catabolic process", "positive regulation of cellobiose catabolism", "up regulation of cellobiose catabolic process", "up regulation of cellobiose catabolism"], "types": ["T044"], "canonical_name": "positive regulation of cellobiose catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of cellobiose catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548350", "aliases": ["down regulation of cellobiose catabolic process", "down regulation of cellobiose catabolism", "downregulation of cellobiose catabolism", "negative regulation of cellobiose catabolism", "down-regulation of cellobiose catabolic process", "down-regulation of cellobiose catabolism", "downregulation of cellobiose catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of cellobiose catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548351", "aliases": ["regulation of cellobiose catabolism"], "types": ["T044"], "canonical_name": "regulation of cellobiose catabolic process", "definition": "Any process that modulates the frequency, rate or extent of cellobiose catabolic process. [GOC:mengo_curators, GOC:TermGenie]"}
{"concept_id": "C3548352", "aliases": ["up-regulation of CD4-positive, alpha beta T cell costimulation", "up regulation of CD4-positive, alpha beta T cell costimulation", "upregulation of CD4-positive, alpha beta T cell costimulation", "positive regulation of CD4-positive, alpha beta T cell costimulation"], "types": ["T043"], "canonical_name": "positive regulation of CD4-positive, alpha-beta T cell costimulation", "definition": "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation. [GOC:BHF, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3548353", "aliases": ["down-regulation of CD4-positive, alpha beta T cell costimulation", "negative regulation of CD4-positive, alpha beta T cell costimulation", "downregulation of CD4-positive, alpha beta T cell costimulation", "down regulation of CD4-positive, alpha beta T cell costimulation"], "types": ["T043"], "canonical_name": "negative regulation of CD4-positive, alpha-beta T cell costimulation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation. [GOC:BHF, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3548354", "aliases": ["regulation of CD4-positive, alpha beta T cell costimulation"], "types": ["T043"], "canonical_name": "regulation of CD4-positive, alpha-beta T cell costimulation", "definition": "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation. [GOC:BHF, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3548355", "aliases": ["up regulation of proteinase activated receptor activity", "up-regulation of proteinase activated receptor activity", "upregulation of proteinase activated receptor activity"], "types": ["T039"], "canonical_name": "positive regulation of proteinase activated receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of proteinase activated receptor activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548356", "aliases": ["down regulation of proteinase activated receptor activity", "down-regulation of proteinase activated receptor activity", "downregulation of proteinase activated receptor activity"], "types": ["T039"], "canonical_name": "negative regulation of proteinase activated receptor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of proteinase activated receptor activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548357", "aliases": [], "types": ["T043"], "canonical_name": "regulation of proteinase activated receptor activity", "definition": "Any process that modulates the frequency, rate or extent of proteinase activated receptor activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548358", "aliases": ["down-regulation of phospholipase C activity", "downregulation of phospholipase C activity", "down regulation of phospholipase C activity"], "types": ["T044"], "canonical_name": "negative regulation of phospholipase C activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548359", "aliases": [], "types": ["T040"], "canonical_name": "regulation of phospholipase C activity", "definition": "Any process that modulates the frequency, rate or extent of phospholipase C activity. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548360", "aliases": ["upregulation of long-term synaptic potentiation", "up regulation of long-term synaptic potentiation", "up-regulation of long-term synaptic potentiation"], "types": ["T039"], "canonical_name": "positive regulation of long-term synaptic potentiation", "definition": "Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548361", "aliases": ["down-regulation of long-term synaptic potentiation", "downregulation of long-term synaptic potentiation", "down regulation of long-term synaptic potentiation"], "types": ["T038"], "canonical_name": "negative regulation of long-term synaptic potentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]"}
{"concept_id": "C3548362", "aliases": ["internal head protein"], "types": ["T026"], "canonical_name": "viral capsid, internal space", "definition": "The region of a virus contained within the capsid shell, and usually containing the viral genome and accessory proteins. [GOC:bm]"}
{"concept_id": "C3548363", "aliases": [], "types": ["T039"], "canonical_name": "virus baseplate assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a virus baseplate. [GOC:bm]"}
{"concept_id": "C3548364", "aliases": ["copy-and-paste transposition", "transpositional DNA genome replication"], "types": ["T045"], "canonical_name": "replicative transposition, DNA-mediated", "definition": "Process of transposition in which the existing element is replicated and one of the copies is excised and integrated at a new target site. Also referred to as copy-and-paste transposition. [GOC:bm, PMID:10540284]"}
{"concept_id": "C3548365", "aliases": ["cut-and-paste transposition"], "types": ["T045"], "canonical_name": "non-replicative transposition, DNA-mediated", "definition": "Process by which a transposable element is excised from the donor site and integrated at the target site without replication of the element. Also referred to as cut-and-paste transposition. [GOC:bm, PMID:2553270]"}
{"concept_id": "C3548366", "aliases": [], "types": ["T045"], "canonical_name": "viral DNA genome packaging, 5' extended cos packaging", "definition": "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 5' protruding ends. [GOC:bm]"}
{"concept_id": "C3548367", "aliases": [], "types": ["T045"], "canonical_name": "viral DNA genome packaging, 3' extended cos packaging", "definition": "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 3' protruding ends. [GOC:bm]"}
{"concept_id": "C3548368", "aliases": [], "types": ["T045"], "canonical_name": "viral DNA genome packaging via site-specific sequence recognition", "definition": "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites by a viral terminase. [GOC:bm]"}
{"concept_id": "C3548369", "aliases": [], "types": ["T026"], "canonical_name": "icosahedral viral capsid, neck fiber", "definition": "A fiber attached to the neck at the base of some icosahedral viral capsids. [GOC:bm]"}
{"concept_id": "C3548370", "aliases": [], "types": ["T026"], "canonical_name": "icosahedral viral capsid, collar fiber", "definition": "A fiber attached to the collar structure of some icosahedral viral capsids. [GOC:bm]"}
{"concept_id": "C3548371", "aliases": [], "types": ["T026"], "canonical_name": "icosahedral viral capsid, collar", "definition": "A small disk located at the base of some icosahedral virus capsids. [GOC:bm]"}
{"concept_id": "C3548372", "aliases": [], "types": ["T026"], "canonical_name": "icosahedral viral capsid, neck", "definition": "A region of constriction located below the head and above the tail sheath of viruses with contractile tails (Myoviridae). [GOC:bm]"}
{"concept_id": "C3548373", "aliases": [], "types": ["T026"], "canonical_name": "icosahedral viral capsid, spike", "definition": "A short structure attached to an icosahedral virion capsid, and used for attachment to the host cell. [GOC:bm]"}
{"concept_id": "C3548374", "aliases": [], "types": ["T026"], "canonical_name": "virus tail, shaft", "definition": "The tube of the non-contractile tails of some viruses. [GOC:bm]"}
{"concept_id": "C3548375", "aliases": [], "types": ["T026"], "canonical_name": "virus tail, sheath", "definition": "The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm. [GOC:bm]"}
{"concept_id": "C3548376", "aliases": [], "types": ["T026"], "canonical_name": "virus tail, tube", "definition": "The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm. [GOC:bm]"}
{"concept_id": "C3548377", "aliases": [], "types": ["T026"], "canonical_name": "virus tail, baseplate", "definition": "Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached. [GOC:bm]"}
{"concept_id": "C3548378", "aliases": [], "types": ["T026"], "canonical_name": "virus tail, fiber", "definition": "The fibrous region of the virus tail used to scan, recognize and attach to the host cell. [GOC:bm]"}
{"concept_id": "C3548379", "aliases": [], "types": ["T026"], "canonical_name": "virus tail, tip", "definition": "The basal end of the virus tail, which is used by the virus to attach to the host cell. [GOC:bm]"}
{"concept_id": "C3548380", "aliases": [], "types": ["T026"], "canonical_name": "viral capsid, fiber", "definition": "A type of capsid decoration composed of fiber structures. [GOC:bm]"}
{"concept_id": "C3548381", "aliases": [], "types": ["T026"], "canonical_name": "viral capsid, decoration", "definition": "Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential. [GOC:bm]"}
{"concept_id": "C3548384", "aliases": ["minor capsomere"], "types": ["T026"], "canonical_name": "viral capsid, minor subunit", "definition": "The part of the viral capsid that comprises the less common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the pentameric capsomeres are minor subunits. [GOC:bm]"}
{"concept_id": "C3548385", "aliases": ["major capsomere"], "types": ["T026"], "canonical_name": "viral capsid, major subunit", "definition": "The part of the viral capsid that comprises the most common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the hexameric capsomeres are major subunits. [GOC:bm]"}
{"concept_id": "C3548386", "aliases": [], "types": ["T026"], "canonical_name": "virus tail", "definition": "Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell. [GOC:bm]"}
{"concept_id": "C3548387", "aliases": ["viral terminase, large subunit"], "types": ["T026"], "definition": "The part of the viral terminase complex that contains the translocase and endonuclease activities and allows the translocation of the phage DNA into the procapsid. The large subunit usually assembles as a heterooligomer with the small subunit. [GOC:bm, GOC:ch, GOC:jh2, PMID:18687036]", "canonical_name": "virus terminase, large subunit"}
{"concept_id": "C3548388", "aliases": [], "types": ["T045"], "canonical_name": "viral DNA genome packaging, headful", "definition": "The encapsulation of the viral genome within the capsid where DNA is packaged into the capsid until the capsid is full. [GOC:bm]"}
{"concept_id": "C3548389", "aliases": ["virus head-tail joining"], "types": ["T039"], "canonical_name": "viral head-tail joining", "definition": "Process by which virus heads and tails are attached to each other. [GOC:bm]"}
{"concept_id": "C3548390", "aliases": [], "types": ["T039"], "canonical_name": "virus tail fiber assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber. [GOC:bm]"}
{"concept_id": "C3548391", "aliases": ["virus tail assembly"], "types": ["T039"], "canonical_name": "viral tail assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a virus tail. [GOC:bm]"}
{"concept_id": "C3548392", "aliases": ["irreversible bacteriophage attachment, binding of host cell surface receptor"], "types": ["T038"], "canonical_name": "receptor-mediated bacteriophage irreversible attachment to host cell", "definition": "The processes by which a bacteriophage initially commits to infection by binding the host receptor irreversibly. Disruption of the phage:cell complex at this step results in the loss of infective phage virions since the process is characterized by conformational changes of bacteriophage head and tail proteins and injection of bacteriophage proteins into the infected cell. [GOC:bm]"}
{"concept_id": "C3548393", "aliases": ["reversible bacteriophage attachment, binding of host cell surface receptor"], "types": ["T038"], "canonical_name": "receptor-mediated bacteriophage reversible attachment to host cell", "definition": "Process by which a bacteriophage, using its tail fibers, spikes or a baseplate component, initially recognizes and binds to its specific receptor on the host cell surface. This process is reversible and allows the release of a bacteriophage without affecting infection. [GOC:bm]"}
{"concept_id": "C3548394", "aliases": ["cone photoreceptor apoptotic process"], "types": ["T043"], "canonical_name": "retinal cone cell apoptotic process", "definition": "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. [CL:0000573, GOC:jc]"}
{"concept_id": "C3548395", "aliases": ["rod photoreceptor apoptotic process"], "types": ["T043"], "canonical_name": "retinal rod cell apoptotic process", "definition": "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. [CL:0000604, GOC:jc, PMID:17202487]"}
{"concept_id": "C3548396", "aliases": ["cerebellar mossy fiber to granule cell synapse"], "types": ["T030"], "canonical_name": "mossy fiber rosette", "definition": "A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes. [NIF_Subcellular:nlx_subcell_091021, Wikipedia:Mossy_fiber_(cerebellum)]"}
{"concept_id": "C3548398", "aliases": ["PCD in response to reactive oxygen species", "reactive oxygen species-mediated PCD", "reactive oxygen species-mediated programmed cell death"], "types": ["T043"], "canonical_name": "programmed cell death in response to reactive oxygen species", "definition": "Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:mtg_apoptosis]"}
{"concept_id": "C3548399", "aliases": ["type III terminal button"], "types": ["T026"], "canonical_name": "type III terminal bouton", "definition": "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. Type III terminal boutons are larger than type II ones. [GOC:mc, PMID:10218156]"}
{"concept_id": "C3548400", "aliases": [], "types": ["T044"], "canonical_name": "misfolded or incompletely synthesized glycoprotein catabolic process"}
{"concept_id": "C3548401", "aliases": [], "types": ["T026"], "canonical_name": "somatic spine", "definition": "Spine emanating from the cell soma of a neuron. [NIF_Subcellular:sao2048514053]"}
{"concept_id": "C3548402", "aliases": [], "types": ["T026"], "canonical_name": "thorny excrescence", "definition": "Large complex spine protruding from a dendrite. Each excrescence is formed by a cluster of spine heads. [NIF_Subcellular:nlx_467, PMID:730852]"}
{"concept_id": "C3548403", "aliases": [], "types": ["T026"], "canonical_name": "gemmule", "definition": "Spine-like process found on some neurons, e.g., periglomerular cells of olfactory cortex. [NIF_Subcellular:nlx_subcell_1005003]"}
{"concept_id": "C3548404", "aliases": [], "types": ["T026"], "definition": "Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease. [NIF_Subcellular:sao601362597]", "canonical_name": "Lewy neurite"}
{"concept_id": "C3548406", "aliases": ["terminal loop of Schwann cell"], "types": ["T026"], "canonical_name": "terminal loop", "definition": "Portion of myelin-forming Schwann cell consisting of terminal cytoplasmic extensions adhered to the axon at the beginning and end of the myelin sheath. [NIF_Subcellular:sao924713546]"}
{"concept_id": "C3548407", "aliases": [], "types": ["T026"], "canonical_name": "spiny bracelet of Nageotte", "definition": "Paranodal terminations of Schwann cells that do not directly contact the paranodal axon membrane. Usually found in thicker myelin. [NIF_Subcellular:sao937871668, PMID:15988042]"}
{"concept_id": "C3548408", "aliases": [], "types": ["T026"], "canonical_name": "Schwann cell microvillus", "definition": "Small finger-like extension of a Schwann cell that contacts the nodal membrane. [NIF_Subcellular:sao1890444066, PMID:15988042]"}
{"concept_id": "C3548409", "aliases": [], "types": ["T026"], "canonical_name": "mesaxon", "definition": "Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide. [ISBN:0195065719, NIF_Subcellular:sao2127666702]"}
{"concept_id": "C3548410", "aliases": ["glial limiting endfoot"], "types": ["T026"], "canonical_name": "glial limiting end-foot", "definition": "Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans. [NIF_Subcellular:sao181458425]"}
{"concept_id": "C3548411", "aliases": ["astrocyte endfoot"], "types": ["T026"], "canonical_name": "astrocyte end-foot", "definition": "Terminal process of astrocyte abutting non-neuronal surfaces in the brain. [NIF_Subcellular:sao388182739]"}
{"concept_id": "C3548412", "aliases": ["astrocyte process"], "types": ["T026"], "canonical_name": "astrocyte projection", "definition": "A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. [NIF_Subcellular:sao1630537580]"}
{"concept_id": "C3548413", "aliases": [], "types": ["T026"], "canonical_name": "spine mat", "definition": "A configuration of neuron spines found on ciliary ganglion neurons in the embryonic and adult brain consisting of patches of closely spaced spines lying flat against the soma. [NIF_Subcellular:sao2128156969, PMID:10818137]"}
{"concept_id": "C3548414", "aliases": [], "types": ["T026"], "canonical_name": "dendritic tree", "definition": "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches. [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]"}
{"concept_id": "C3548415", "aliases": ["pre-synaptic active zone dense projection", "active zone dense projection"], "types": ["T026"], "canonical_name": "presynaptic active zone dense projection", "definition": "Electron dense projection extending from the cytomatrix into the cytoplasm on which synaptic vesicles are tethered. [NIF_Subcellular:sao494258938, PMID:15381754]"}
{"concept_id": "C3548416", "aliases": [], "types": ["T026"], "canonical_name": "spine apparatus", "definition": "A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum. [NIF_Subcellular:sao725931194, PMID:20400711, PMID:8987748]"}
{"concept_id": "C3548417", "aliases": [], "types": ["T026"], "canonical_name": "sorting endosome", "definition": "A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles. [NIF_Subcellular:sao1028571114]"}
{"concept_id": "C3548418", "aliases": [], "types": ["T026"], "canonical_name": "CA3 pyramidal cell dendrite", "definition": "A dendrite of a hippocampal CA3 pyramidal cell. [NIF_Subcellular:nlx_subcell_1005001]"}
{"concept_id": "C3548419", "aliases": ["basilar dendrite"], "types": ["T026"], "canonical_name": "basal dendrite", "definition": "A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon. [GOC:aruk, GOC:bc, NIF_Subcellular:sao1079900774, PMID:17046728, PMID:22683681]"}
{"concept_id": "C3548420", "aliases": [], "types": ["T026"], "canonical_name": "apical dendrite", "definition": "A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. [NIF_Subcellular:sao273773228]"}
{"concept_id": "C3548421", "aliases": ["release from dormancy"], "types": ["T039"], "canonical_name": "exit from dormancy", "definition": "The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated. [GOC:PO_curators, PO_REF:00009]"}
{"concept_id": "C3548422", "aliases": [], "types": ["T039"], "canonical_name": "maintenance of dormancy", "definition": "The dormancy process that results in an organism remaining in dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated. [GOC:PO_curators, PO_REF:00009]"}
{"concept_id": "C3548423", "aliases": ["induction of dormancy"], "types": ["T039"], "canonical_name": "entry into dormancy", "definition": "The dormancy process that results in entry into dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated. [GOC:PO_curators, PO_REF:00009]"}
{"concept_id": "C3548424", "aliases": ["succinate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "succinate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in). [GOC:al, PMID:1293882]"}
{"concept_id": "C3548425", "aliases": [], "types": ["T026"], "definition": "An electron dense body which may contain granules. [ISBN:0195065719, NIF_Subcellular:sao730872736]", "canonical_name": "dense body"}
{"concept_id": "C3548426", "aliases": [], "types": ["T043"], "canonical_name": "hippocampal pyramidal neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus. [CL:1001571, GOC:jc, PMID:19342486]"}
{"concept_id": "C3548427", "aliases": [], "types": ["T026"], "canonical_name": "mitotic spindle pole", "definition": "Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:vw]"}
{"concept_id": "C3548428", "aliases": [], "types": ["T044"], "canonical_name": "amino acid ligation activity by nonribosomal peptide synthase", "definition": "Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase. [GOC:vw]"}
{"concept_id": "C3548429", "aliases": [], "types": ["T044"], "canonical_name": "protein maturation by iron-sulfur cluster transfer", "definition": "The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977]"}
{"concept_id": "C3548431", "aliases": [], "types": ["T026"], "canonical_name": "nucleolus-associated heterochromatin", "definition": "Dense particles of heterochromatin, consisting of a loosely twisted strand about 600 Angstrom thick, found associated with the nucleolus. [NIF_Subcellular:sao1210952635]"}
{"concept_id": "C3548432", "aliases": [], "types": ["T026"], "canonical_name": "tubular endosome", "definition": "A network of fine tubules in the vicinity of the Golgi complex and around the centriole. [NIF_Subcellular:sao1570660411, NIF_Subcellular:sao694815499, PMID:11896161]"}
{"concept_id": "C3548433", "aliases": [], "types": ["T026"], "canonical_name": "skein-like inclusion", "definition": "Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin. [NIF_Subcellular:nlx_subcell_20090103, PMID:18026741]"}
{"concept_id": "C3548434", "aliases": [], "types": ["T026"], "canonical_name": "nematosome", "definition": "Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles. [NIF_Subcellular:sao138430598, PMID:5458990]"}
{"concept_id": "C3548435", "aliases": ["LBHI"], "types": ["T026"], "canonical_name": "Lewy body-like hyaline inclusion", "definition": "Cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments. [NIF_Subcellular:nlx_subcell_20090105, PMID:18026741]"}
{"concept_id": "C3548436", "aliases": [], "types": ["T026"], "canonical_name": "cortical Lewy body", "definition": "Cytoplasmic inclusion similar to a classical Lewy body but lacking a halo of protein fibrils. [NIF_Subcellular:sao4040591221]"}
{"concept_id": "C3548437", "aliases": [], "types": ["T026"], "canonical_name": "classical Lewy body", "definition": "Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils. [NIF_Subcellular:sao4749542545]"}
{"concept_id": "C3548438", "aliases": ["HIF1alpha pathway", "hypoxia-inducible factor signaling", "hypoxia-inducible factor-1alpha signalling pathway"], "types": ["T043"], "canonical_name": "hypoxia-inducible factor-1alpha signaling pathway", "definition": "The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. [GOC:bf, GOC:jc, http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway]"}
{"concept_id": "C3548439", "aliases": [], "types": ["T043"], "canonical_name": "hippocampal interneuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron. [CL:1001569, GOC:jc, PMID:19655320]"}
{"concept_id": "C3548440", "aliases": ["GCI"], "types": ["T026"], "canonical_name": "glial cytoplasmic inclusion", "definition": "Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy. [NIF_Subcellular:nlx_subcell_20090703, PMID:21562886, PMID:2559165]"}
{"concept_id": "C3548441", "aliases": [], "types": ["T026"], "canonical_name": "fibrillary inclusion", "definition": "Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra. [NIF_Subcellular:sao967812059]"}
{"concept_id": "C3548444", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to raffinose", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus. [GOC:al]"}
{"concept_id": "C3548445", "aliases": [], "types": ["T043"], "canonical_name": "neuroblast migration", "definition": "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. [CL:0000031, GOC:jc, PMID:15543145]"}
{"concept_id": "C3548446", "aliases": ["synaptic vesicle lumen pH reduction", "synaptic vesicle proton loading"], "types": ["T043"], "canonical_name": "synaptic vesicle lumen acidification", "definition": "The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading. [GOC:dsf, PMID:21172605, PMID:22875945]"}
{"concept_id": "C3548447", "aliases": ["IL-17-mediated signaling pathway", "IL-17-mediated signalling pathway", "interleukin-17-mediated signalling pathway"], "types": ["T043"], "canonical_name": "interleukin-17-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ic, PMID:21602493]"}
{"concept_id": "C3548448", "aliases": ["IL-32-mediated signaling pathway", "IL-32-mediated signalling pathway", "interleukin-32-mediated signalling pathway"], "types": ["T043"], "canonical_name": "interleukin-32-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-32 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ic, PMID:21602493]"}
{"concept_id": "C3548449", "aliases": ["cellular response to IL-17"], "types": ["T043"], "canonical_name": "cellular response to interleukin-17", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus. [GOC:pr]"}
{"concept_id": "C3548450", "aliases": ["cellular response to IL-32"], "types": ["T043"], "canonical_name": "cellular response to interleukin-32", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus. [GOC:pr]"}
{"concept_id": "C3548451", "aliases": ["response to IL-17"], "types": ["T043"], "canonical_name": "response to interleukin-17", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus. [GOC:pr]"}
{"concept_id": "C3548452", "aliases": ["response to IL-32"], "types": ["T043"], "canonical_name": "response to interleukin-32", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus. [GOC:pr]"}
{"concept_id": "C3548453", "aliases": [], "types": ["T045"], "canonical_name": "telomeric RNA transcription from Pol II promoter"}
{"concept_id": "C3548454", "aliases": ["CXCL16 production"], "types": ["T044"], "canonical_name": "chemokine (C-X-C motif) ligand 16 production", "definition": "The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3548455", "aliases": ["CXCL13 production"], "types": ["T044"], "canonical_name": "chemokine (C-X-C motif) ligand 13 production", "definition": "The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3548456", "aliases": ["CXCL12 production"], "types": ["T044"], "canonical_name": "chemokine (C-X-C motif) ligand 12 production", "definition": "The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3548457", "aliases": ["CCL21 production"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 21 production", "definition": "The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3548458", "aliases": ["CCL19 production", "EBI1 ligand chemokine production", "ELC production", "macrophage inflammatory protein-3-beta production", "MIP-3-beta production"], "types": ["T044"], "canonical_name": "chemokine (C-C motif) ligand 19 production", "definition": "The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3548459", "aliases": [], "types": ["T026"], "canonical_name": "capitate projection", "definition": "Simple or compound process of epithelial glial cells with a spherical head that inserts into photoreceptor axons. Capitate projections have only been observed in Brachycera (flies). [GOC:mc, PMID:3098431]"}
{"concept_id": "C3548460", "aliases": [], "types": ["T026"], "canonical_name": "glial cell projection", "definition": "A prolongation or process extending from a glial cell. [GOC:mc]"}
{"concept_id": "C3548461", "aliases": ["necrotic cell death in response to starvation"], "types": ["T040"], "canonical_name": "programmed necrotic cell death in response to starvation", "definition": "A programmed necrotic cell death occurring as a result of a starvation stimulus (deprivation of nourishment). [GOC:mtg_apoptosis, GOC:pg, PMID:13679856]"}
{"concept_id": "C3548462", "aliases": ["cellular lipid biosynthesis", "cellular lipid anabolism", "cellular lipid synthesis", "cellular lipid formation"], "types": ["T044"], "canonical_name": "cellular lipid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells. [GOC:pr]"}
{"concept_id": "C3548463", "aliases": ["deoxyinosine-diphosphatase activity"], "types": ["T044"], "canonical_name": "dIDP diphosphatase activity", "definition": "Catalysis of the reaction: dIDP + H2O = dIMP + phosphate. [GOC:pde, PMID:20385596]"}
{"concept_id": "C3548464", "aliases": [], "types": ["T044"], "canonical_name": "deoxynucleoside-diphosphatase activity", "definition": "Catalysis of the reaction: a deoxynucleoside diphosphate + H2O = a deoxynucleotide + phosphate. [GOC:pde]"}
{"concept_id": "C3548465", "aliases": [], "types": ["T026"], "canonical_name": "photoreceptor disc membrane", "definition": "Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane. [GOC:bj, GOC:krc, GOC:pde, PMID:11826267, PMID:19501669, PMID:2537204, PMID:26574505, PMID:6771304, PMID:7507907]"}
{"concept_id": "C3548466", "aliases": [], "types": ["T043"], "canonical_name": "dorsal spinal cord interneuron anterior axon guidance", "definition": "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:yaf, PMID:19545367]"}
{"concept_id": "C3548467", "aliases": [], "types": ["T043"], "canonical_name": "dorsal spinal cord interneuron posterior axon guidance", "definition": "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the posterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:yaf, PMID:19545367]"}
{"concept_id": "C3548468", "aliases": ["dorsal interneuron axon guidance"], "types": ["T043"], "canonical_name": "dorsal spinal cord interneuron axon guidance", "definition": "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord. [GOC:yaf]"}
{"concept_id": "C3548469", "aliases": [], "types": ["T043"], "canonical_name": "spinal cord interneuron axon guidance", "definition": "The process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord. [CL:0005000, GOC:pr]"}
{"concept_id": "C3548470", "aliases": [], "types": ["T043"], "canonical_name": "interneuron axon guidance", "definition": "The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions. [CL:0000099, GOC:pr]"}
{"concept_id": "C3548471", "aliases": [], "types": ["T043"], "canonical_name": "spinal sensory neuron axon guidance", "definition": "The process in which the migration of an axon growth cone of a spinal sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal sensory neuron is a sensory neuron that project to the spinal cord. [CL:0009000, GOC:pr, GOC:yaf]"}
{"concept_id": "C3548472", "aliases": [], "types": ["T043"], "canonical_name": "sensory neuron axon guidance", "definition": "The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses. [CL:0000101, GOC:pr]"}
{"concept_id": "C3548473", "aliases": [], "types": ["T045"], "canonical_name": "NAD-dependent histone deacetylase activity (H3-K18 specific)", "definition": "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein. [GOC:sp, PMID:22722849, PMID:28450737]"}
{"concept_id": "C3548474", "aliases": [], "types": ["T044"], "canonical_name": "MDM2/MDM4 family protein binding", "definition": "Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53. [InterPro:IPR016495]"}
{"concept_id": "C3548475", "aliases": [], "types": ["T044"], "canonical_name": "protein O-GlcNAcylation via threonine", "definition": "The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine. [GOC:pr, GOC:sart, PMID:22158438]"}
{"concept_id": "C3548477", "aliases": ["establishment of BTB", "establishment of SCB", "establishment of blood-testis barrier"], "types": ["T043"], "canonical_name": "establishment of Sertoli cell barrier", "definition": "Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions. [GOC:sl, PMID:19509333, Wikipedia:Blood-testis_barrier]"}
{"concept_id": "C3548478", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate derivative binding", "definition": "Binding to a carbohydrate derivative. [GOC:pr]"}
{"concept_id": "C3548479", "aliases": ["response to bronchodilator agent"], "types": ["T040"], "canonical_name": "response to bronchodilator", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes. [GOC:hp]"}
{"concept_id": "C3548480", "aliases": [], "types": ["T044"], "canonical_name": "stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential", "definition": "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758]"}
{"concept_id": "C3548481", "aliases": [], "types": ["T044"], "canonical_name": "stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential", "definition": "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758]"}
{"concept_id": "C3548482", "aliases": [], "types": ["T043"], "canonical_name": "chorionic trophoblast cell proliferation", "definition": "The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population. [CL:0011101, GOC:BHF, PMID:15150278]"}
{"concept_id": "C3548483", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucosylation", "definition": "The covalent attachment of a UDP-glucose residue to a substrate molecule. [GOC:al]"}
{"concept_id": "C3548484", "aliases": [], "types": ["T044"], "canonical_name": "D-leucyl-tRNA(Leu) deacylase activity", "definition": "Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu). [GOC:se, PMID:10918062]"}
{"concept_id": "C3548486", "aliases": ["perinucleolar region"], "types": ["T026"], "canonical_name": "perinucleolar compartment", "definition": "The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC. [GOC:vw, PMID:21385875, Wikipedia:Perinucleolar_compartment]"}
{"concept_id": "C3548487", "aliases": ["protein localisation to heterochromatin"], "types": ["T045"], "canonical_name": "protein localization to heterochromatin", "definition": "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. [GOC:mah]"}
{"concept_id": "C3548488", "aliases": ["mediolateral pattern formation"], "types": ["T042"], "canonical_name": "centrolateral pattern formation", "definition": "The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment. [GOC:dsz]"}
{"concept_id": "C3548489", "aliases": ["autophagic vacuole maturation"], "types": ["T043"], "canonical_name": "autophagosome maturation", "definition": "Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. [GOC:autophagy, GOC:lf, PMID:28077293]"}
{"concept_id": "C3548490", "aliases": [], "types": ["T044"], "canonical_name": "toxin-antitoxin pair type II binding"}
{"concept_id": "C3548491", "aliases": [], "types": ["T038"], "canonical_name": "neutrophil clearance", "definition": "The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms. [GOC:BHF, PMID:21957127]"}
{"concept_id": "C3548492", "aliases": [], "types": ["T026"], "canonical_name": "host cell endocytic vesicle membrane", "definition": "The lipid bilayer surrounding a host cell endocytic vesicle. [GOC:ecd]"}
{"concept_id": "C3548493", "aliases": ["mitochondrial outer membrane permeabilization", "MOMP"], "types": ["T043"], "definition": "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:pg, PMID:21041309]", "canonical_name": "mitochondrion outer membrane permeabilization"}
{"concept_id": "C3548494", "aliases": [], "types": ["T044"], "canonical_name": "ripoptosome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. [GOC:mtg_apoptosis, PMID:22274400]"}
{"concept_id": "C3548495", "aliases": [], "types": ["T026"], "canonical_name": "ripoptosome", "definition": "A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. [GOC:bhm, GOC:mtg_apoptosis, PMID:22265414, PMID:22274400]"}
{"concept_id": "C3548496", "aliases": ["prevention of zymogen activation"], "types": ["T045"], "canonical_name": "zymogen inhibition", "definition": "Any process that prevents the proteolytic processing of an inactive enzyme to an active form. [GOC:mtg_apoptosis, PMID:20383739]"}
{"concept_id": "C3548497", "aliases": ["prevention of cysteine-type endopeptidase activity"], "types": ["T044"], "canonical_name": "inhibition of cysteine-type endopeptidase activity", "definition": "Any process that prevents the activation of an inactive cysteine-type endopeptidase. [GOC:mtg_apoptosis, PMID:20383739]"}
{"concept_id": "C3548498", "aliases": ["glycolate membrane transport"], "types": ["T044"], "canonical_name": "glycolate transmembrane transport", "definition": "The process in which glycolate is transported across a membrane. Glycolate is the anion of hydroxyethanoic acid (glycolic acid). [GOC:am, PMID:11283302, PMID:11785976]"}
{"concept_id": "C3548499", "aliases": [], "types": ["T043"], "canonical_name": "response to clozapine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus. [GOC:pr]"}
{"concept_id": "C3548500", "aliases": [], "types": ["T043"], "canonical_name": "response to ziprasidone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms. [GOC:pr]"}
{"concept_id": "C3548501", "aliases": [], "types": ["T043"], "canonical_name": "response to risperidone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus. [GOC:pr]"}
{"concept_id": "C3548502", "aliases": [], "types": ["T043"], "canonical_name": "response to quetiapine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus. [GOC:pr]"}
{"concept_id": "C3548503", "aliases": [], "types": ["T043"], "canonical_name": "response to perphenazine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a perphenazine stimulus. Perphenazine is a phenothiazine derivative having a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position. [GOC:pr]"}
{"concept_id": "C3548504", "aliases": [], "types": ["T043"], "canonical_name": "response to olanzapine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus. [GOC:pr]"}
{"concept_id": "C3548505", "aliases": [], "types": ["T040"], "canonical_name": "response to antipsychotic drug", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. [GOC:pr]"}
{"concept_id": "C3548506", "aliases": [], "types": ["T043"], "canonical_name": "response to cytarabine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus. [GOC:pr]"}
{"concept_id": "C3548507", "aliases": [], "types": ["T043"], "canonical_name": "response to 5-fluoro-2'-deoxyuridine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. [GOC:pr]"}
{"concept_id": "C3548508", "aliases": [], "types": ["T043"], "canonical_name": "response to antimetabolite", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. [GOC:pr]"}
{"concept_id": "C3548509", "aliases": [], "types": ["T043"], "canonical_name": "response to carboplatin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus. [GOC:pr]"}
{"concept_id": "C3548510", "aliases": [], "types": ["T040"], "canonical_name": "response to antineoplastic agent", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms. [GOC:pr]"}
{"concept_id": "C3548511", "aliases": [], "types": ["T043"], "canonical_name": "melanocyte adhesion", "definition": "The attachment of a melanocyte to another cell via adhesion molecules. [CL:0000148, GOC:uh, PMID:22637532]"}
{"concept_id": "C3548512", "aliases": [], "types": ["T043"], "canonical_name": "melanocyte proliferation", "definition": "The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. [CL:0000148, GOC:uh, PMID:22637532]"}
{"concept_id": "C3548513", "aliases": [], "types": ["T043"], "canonical_name": "melanocyte migration", "definition": "The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. [CL:0000148, GOC:uh, PMID:22637532]"}
{"concept_id": "C3548514", "aliases": [], "types": ["T043"], "canonical_name": "B cell adhesion", "definition": "The attachment of a B cell to another cell via adhesion molecules. [GOC:jc]"}
{"concept_id": "C3548515", "aliases": ["7SK small nuclear RNA binding"], "types": ["T045"], "canonical_name": "7SK snRNA binding", "definition": "Binding to a 7SK small nuclear RNA (7SK snRNA). [GOC:nhn, PMID:21853533]"}
{"concept_id": "C3548516", "aliases": [], "types": ["T040"], "canonical_name": "cell growth mode switching, filamentous to budding", "definition": "The process in which a cell switches from growing as a filament (elongated cells attached end-to-end) to growing as a round budding cell. An example of this is observed in Candida albicans. [GOC:di, PMID:14617167]"}
{"concept_id": "C3548517", "aliases": ["membrane tubulation"], "types": ["T043"], "definition": "A membrane tubulation process occurring in a plasma membrane. [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]", "canonical_name": "plasma membrane tubulation"}
{"concept_id": "C3548519", "aliases": [], "types": ["T040"], "canonical_name": "invasive growth in response to abiotic stimulus", "definition": "The growth of colonies in filamentous chains of cells as a result of a abiotic stimulus. An example of this process is found in Candida albicans. [GOC:di, PMID:18679170]"}
{"concept_id": "C3548520", "aliases": [], "types": ["T040"], "canonical_name": "invasive growth in response to biotic stimulus", "definition": "The growth of colonies in filamentous chains of cells as a result of a biotic stimulus. An example of this is Candida albicans forming invasive filaments in agar medium in response to a serum stimulus. [GOC:di, PMID:18679170]"}
{"concept_id": "C3548521", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to N-acetyl-D-glucosamine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus. [GOC:di, PMID:21700702]"}
{"concept_id": "C3548522", "aliases": [], "types": ["T043"], "canonical_name": "response to N-acetyl-D-glucosamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus. [GOC:di, PMID:21700702]"}
{"concept_id": "C3548523", "aliases": ["apoptosome formation"], "types": ["T044"], "canonical_name": "apoptosome assembly", "definition": "The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process. [GOC:mtg_apoptosis]"}
{"concept_id": "C3548524", "aliases": [], "types": ["T026"], "canonical_name": "bacterial biofilm matrix surface", "definition": "The external part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria. [GOC:imk, PMID:22571672, Wikipedia:Biofilm]"}
{"concept_id": "C3548526", "aliases": [], "types": ["T024"], "canonical_name": "bacterial biofilm matrix", "definition": "A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria. [GOC:imk, PMID:22571672, Wikipedia:Biofilm]"}
{"concept_id": "C3548527", "aliases": [], "types": ["T045"], "canonical_name": "cap2 mRNA methylation", "definition": "Methylation of the ribose of the first and second nucleotides of a 5'-capped mRNA. [GOC:sp, PMID:20713356]"}
{"concept_id": "C3548528", "aliases": [], "types": ["T045"], "canonical_name": "cap1 mRNA methylation", "definition": "Methylation of the ribose of the first nucleotide of a 5'-capped mRNA. [GOC:sp, PMID:20713356]"}
{"concept_id": "C3548529", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to farnesol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus. [GOC:di, PMID:11425711]"}
{"concept_id": "C3548530", "aliases": [], "types": ["T043"], "canonical_name": "response to farnesol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus. [GOC:pr]"}
{"concept_id": "C3548531", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to alcohol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. [GOC:pr]"}
{"concept_id": "C3548532", "aliases": [], "types": ["T043"], "canonical_name": "response to alcohol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. [GOC:pr, PMID:24014527]"}
{"concept_id": "C3548533", "aliases": ["lipoprotein biosynthesis (signal peptide cleavage)"], "types": ["T044"], "canonical_name": "lipoprotein biosynthetic process via signal peptide cleavage", "definition": "The chemical reactions and pathways by which signal peptide cleavage leads to formation of a water-soluble protein-lipid complex. [GOC:pde, GOC:yaf, UniPathway:UPA00665]"}
{"concept_id": "C3548534", "aliases": ["lipoprotein biosynthesis (N-acyl transfer)"], "types": ["T044"], "canonical_name": "lipoprotein biosynthetic process via N-acyl transfer", "definition": "The chemical reactions and pathways by which N-acyl transfer leads to formation of a water-soluble protein-lipid complex. [GOC:pde, GOC:yaf, UniPathway:UPA00666]"}
{"concept_id": "C3548535", "aliases": ["lipoprotein biosynthesis (diacylglyceryl transfer)"], "types": ["T044"], "canonical_name": "lipoprotein biosynthetic process via diacylglyceryl transfer", "definition": "The chemical reactions and pathways by which diacylglyceryl transfer leads to formation of a water-soluble protein-lipid complex. [GOC:pde, GOC:yaf, UniPathway:UPA00664]"}
{"concept_id": "C3548536", "aliases": ["cellular potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter"], "types": ["T043"], "canonical_name": "regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter", "definition": "Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:dgf, PMID:20412803]"}
{"concept_id": "C3548538", "aliases": ["regulation of nuclear size", "regulation of nuclear volume"], "types": ["T039"], "canonical_name": "regulation of nucleus size", "definition": "Any process that modulates the size of the nucleus. [GOC:al, GOC:mah, PMID:19366728]"}
{"concept_id": "C3548539", "aliases": [], "types": ["T044"], "canonical_name": "activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis", "definition": "Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the execution phase of apoptosis. [GOC:mtg_apoptosis]"}
{"concept_id": "C3548540", "aliases": ["activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway"], "types": ["T044"], "canonical_name": "activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway", "definition": "Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. [GOC:mtg_apoptosis]"}
{"concept_id": "C3548541", "aliases": ["morphine formation", "morphine biosynthesis", "morphine synthesis", "morphine anabolism"], "types": ["T044"], "canonical_name": "morphine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum. [GOC:yaf, UniPathway:UPA00852]"}
{"concept_id": "C3548542", "aliases": ["'de novo' XMP anabolism", "'de novo' XMP biosynthesis", "'de novo' XMP synthesis", "'de novo' XMP formation"], "types": ["T044"], "canonical_name": "'de novo' XMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors. [GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, UniPathway:UPA00601]"}
{"concept_id": "C3548543", "aliases": ["XMP synthesis", "XMP anabolism", "XMP biosynthesis", "XMP formation"], "types": ["T044"], "canonical_name": "XMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate. [GOC:yaf]"}
{"concept_id": "C3548544", "aliases": ["XMP metabolism"], "types": ["T044"], "canonical_name": "XMP metabolic process", "definition": "The chemical reactions and pathways involving XMP, xanthosine monophosphate. [GOC:yaf]"}
{"concept_id": "C3548545", "aliases": ["renal phosphate absorption"], "types": ["T039"], "canonical_name": "renal phosphate ion absorption", "definition": "A renal system process in which phosphate ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:lb, PMID:18784102, PMID:22506049]"}
{"concept_id": "C3548546", "aliases": ["alpha-ribazole biosynthesis", "alpha-ribazole synthesis", "alpha-ribazole anabolism", "alpha-ribazole formation"], "types": ["T044"], "canonical_name": "alpha-ribazole biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12). [GOC:yaf, MetaCyc:PWY-5508, MetaCyc:PWY-6269, UniPathway:UPA00061]"}
{"concept_id": "C3548547", "aliases": ["alpha-ribazole metabolism"], "types": ["T044"], "canonical_name": "alpha-ribazole metabolic process", "definition": "The chemical reactions and pathways involving alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12). [GOC:yaf]"}
{"concept_id": "C3548548", "aliases": ["7-cyano-7-deazaguanine synthesis", "7-cyano-7-deazaguanine biosynthesis", "7-cyano-7-deazaguanine formation", "7-cyano-7-deazaguanine anabolism"], "types": ["T044"], "canonical_name": "7-cyano-7-deazaguanine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo. [GOC:yaf, PMID:364423, UniPathway:UPA00391]"}
{"concept_id": "C3548549", "aliases": ["7-cyano-7-deazaguanine metabolism"], "types": ["T044"], "canonical_name": "7-cyano-7-deazaguanine metabolic process", "definition": "The chemical reactions and pathways involving the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo. [GOC:yaf, PMID:364423]"}
{"concept_id": "C3548550", "aliases": [], "types": ["T043"], "canonical_name": "iron ion import"}
{"concept_id": "C3548551", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to toxic substance", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:pr]"}
{"concept_id": "C3548552", "aliases": [], "types": ["T043"], "canonical_name": "chlorophyll fluorescence", "definition": "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is re-emitted as light. [PMID:10938857]"}
{"concept_id": "C3548553", "aliases": [], "types": ["T026"], "canonical_name": "Flemming body", "definition": "A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge. [GOC:pm, PMID:18641129, PMID:22522702]"}
{"concept_id": "C3548554", "aliases": [], "types": ["T044"], "canonical_name": "ELYC domain binding", "definition": "Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC. [GOC:pm, PMID:18032582, PMID:19525971]"}
{"concept_id": "C3548555", "aliases": [], "types": ["T044"], "canonical_name": "MIT domain binding", "definition": "Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking. [GOC:pm, InterPro:IPR007330]"}
{"concept_id": "C3548556", "aliases": ["bacterial cellulose biosynthesis"], "types": ["T044"], "canonical_name": "bacterial cellulose biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria. [DOI:10.1016/S0268-005X(87)80024-3, DOI:10.1023/A:1009272904582, GOC:tb, GOC:yaf, UniPathway:UPA00694]"}
{"concept_id": "C3548557", "aliases": ["peptide pheromone export by membrane transport"], "types": ["T043"], "canonical_name": "peptide pheromone export by transmembrane transport", "definition": "The directed movement of a peptide pheromone across a membrane and out of a cell. [GOC:al, GOC:tb, GOC:vw]"}
{"concept_id": "C3548559", "aliases": ["cell septum assembly involved in cell cycle cytokinesis"], "types": ["T043"], "canonical_name": "cell septum assembly", "definition": "The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3548560", "aliases": [], "types": ["T043"], "canonical_name": "smooth septate junction assembly", "definition": "The assembly of a smooth septate junction, a septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions. [PMID:22854041]"}
{"concept_id": "C3548561", "aliases": [], "types": ["T043"], "canonical_name": "actin filament reorganization", "definition": "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548562", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gluconeogenesis involved in cellular glucose homeostasis"}
{"concept_id": "C3548564", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome-b5 reductase activity, acting on NADH", "definition": "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5). [GOC:tb]"}
{"concept_id": "C3548565", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome-b5 reductase activity, acting on NADPH", "definition": "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5). [GOC:tb, RHEA:64576]"}
{"concept_id": "C3548566", "aliases": ["vesicle tethering to plasma membrane"], "types": ["T043"], "canonical_name": "vesicle tethering involved in exocytosis", "definition": "The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]"}
{"concept_id": "C3548567", "aliases": ["sphingolipid mediated signal transduction", "sphingolipid-mediated signaling pathway"], "types": ["T043"], "canonical_name": "sphingolipid mediated signaling pathway", "definition": "The series of molecular signals mediated by a sphingolipid. [PMID:9525917]"}
{"concept_id": "C3548568", "aliases": [], "types": ["T040"], "canonical_name": "anoxia protection", "definition": "Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia. [GOC:tb, PMID:19372430]"}
{"concept_id": "C3548569", "aliases": ["vacuolar arginine import"], "types": ["T043"], "canonical_name": "L-arginine transmembrane import into vacuole", "definition": "The directed movement of L-arginine into the vacuole across the vacuolar membrane. [GOC:al]"}
{"concept_id": "C3548570", "aliases": [], "types": ["T043"], "canonical_name": "L-lysine transmembrane import into vacuole", "definition": "The directed movement of L-lysine into the vacuole across the vacuolar membrane. [GOC:al]"}
{"concept_id": "C3548571", "aliases": [], "types": ["T043"], "canonical_name": "L-serine transmembrane import into vacuole", "definition": "The directed movement of L-serine into the vacuole across the vacuolar membrane. [GOC:al]"}
{"concept_id": "C3548572", "aliases": [], "types": ["T043"], "canonical_name": "L-glutamate transmembrane import into vacuole", "definition": "The directed movement of L-glutamate into the vacuole across the vacuolar membrane. [GOC:al]"}
{"concept_id": "C3548573", "aliases": [], "types": ["T043"], "canonical_name": "L-tyrosine transmembrane import into vacuole", "definition": "The directed movement of L-tyrosine into the vacuole across the vacuolar membrane. [GOC:al]"}
{"concept_id": "C3548574", "aliases": [], "types": ["T043"], "canonical_name": "L-histidine transmembrane import into vacuole", "definition": "The directed movement of L-histidine into the vacuole across the vacuolar membrane. [GOC:al]"}
{"concept_id": "C3548575", "aliases": [], "types": ["T026"], "canonical_name": "eisosome membrane domain/MCC", "definition": "A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins. [GOC:al, GOC:vw, PMID:22368779]"}
{"concept_id": "C3548576", "aliases": [], "types": ["T043"], "canonical_name": "periclinal cell division", "definition": "A cell division process where the division plane is parallel to the surface of the organ. It creates a new cell layer or cell file. [GOC:tair_curators, PMID:21391814]"}
{"concept_id": "C3548577", "aliases": [], "types": ["T043"], "canonical_name": "anticlinal cell division", "definition": "A cell division process where the division plane is perpendicular to the surface of the organ. It adds cells to the existing cell layer or cell file. [GOC:tair_curators, PMID:21391814]"}
{"concept_id": "C3548579", "aliases": [], "types": ["T044"], "canonical_name": "phenylethylamine biosynthetic process involved in synaptic transmission", "definition": "The chemical reactions and pathways resulting in the formation of phenylethylamine that contribute to synaptic transmission. [GOC:tb]"}
{"concept_id": "C3548580", "aliases": [], "types": ["T043"], "canonical_name": "phenylethylamine metabolic process involved in synaptic transmission", "definition": "The chemical reactions and pathways involving phenylethylamine that contribute to synaptic transmission. [GOC:tb]"}
{"concept_id": "C3548581", "aliases": [], "types": ["T042"], "canonical_name": "epiboly involved in wound healing", "definition": "The expansion of one cell sheet over other cells involved in wound healing. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548582", "aliases": [], "types": ["T042"], "canonical_name": "epiboly", "definition": "The expansion of one cell sheet over other cells or yolk. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548583", "aliases": [], "types": ["T045"], "canonical_name": "RNA phosphodiester bond hydrolysis, exonucleolytic", "definition": "The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548584", "aliases": [], "types": ["T045"], "canonical_name": "RNA phosphodiester bond hydrolysis, endonucleolytic", "definition": "The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548585", "aliases": [], "types": ["T045"], "canonical_name": "RNA phosphodiester bond hydrolysis", "definition": "The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548586", "aliases": [], "types": ["T043"], "canonical_name": "endocardial cushion to mesenchymal transition", "definition": "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548587", "aliases": [], "types": ["T044"], "canonical_name": "pimelyl-[acyl-carrier protein] methyl ester esterase activity", "definition": "Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol. [EC:3.1.1.85, PMID:23045647]"}
{"concept_id": "C3548588", "aliases": ["extrinsic to Golgi membrane"], "types": ["T026"], "canonical_name": "extrinsic component of Golgi membrane", "definition": "The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, PMID:21337012]"}
{"concept_id": "C3548589", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal cell migration", "definition": "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548590", "aliases": [], "types": ["T042"], "canonical_name": "mesenchyme migration involved in limb bud formation", "definition": "The migration of mesenchymal tissue that contributes to the formation of a limb bud. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548591", "aliases": [], "types": ["T044"], "canonical_name": "low-density lipoprotein particle disassembly", "definition": "The disaggregation of a low-density lipoprotein particle into its constituent components. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548592", "aliases": [], "types": ["T043"], "canonical_name": "catecholamine uptake", "definition": "The directed movement of catecholamine into a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548593", "aliases": [], "types": ["T044"], "canonical_name": "N,N-Dihydroxy-L-tryptophan decarboxylase activity", "definition": "Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O. [KEGG_REACTION:R09585]"}
{"concept_id": "C3548594", "aliases": [], "types": ["T044"], "canonical_name": "N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)", "definition": "Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O. [KEGG_REACTION:R09584]"}
{"concept_id": "C3548595", "aliases": [], "types": ["T044"], "canonical_name": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)", "definition": "Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O. [KEGG_REACTION:R09583]"}
{"concept_id": "C3548596", "aliases": [], "types": ["T044"], "canonical_name": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)", "definition": "Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O. [EC:1.14.13.125, KEGG_REACTION:R08160]"}
{"concept_id": "C3548597", "aliases": [], "types": ["T044"], "canonical_name": "polo box domain specific binding", "definition": "Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases. [GOC:al, GOC:tb, Pfam:PF00659, PMID:12352953]"}
{"concept_id": "C3548598", "aliases": ["secondary metabolite catabolism", "secondary metabolite degradation", "secondary metabolite breakdown"], "types": ["T044"], "canonical_name": "secondary metabolite catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. [GOC:tb]"}
{"concept_id": "C3548599", "aliases": ["small RNA 2'-O-methyltransferase"], "types": ["T044"], "canonical_name": "small RNA 2'-O-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA <=> S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide. [GOC:tb, GOC:vw, RHEA:37887]"}
{"concept_id": "C3548602", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity", "definition": "Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine. [PMID:22988102]"}
{"concept_id": "C3548603", "aliases": [], "types": ["T044"], "canonical_name": "vitamin transmembrane transporter activity", "definition": "Enables the transfer of a vitamin from one side of a membrane to the other. [GOC:tb]"}
{"concept_id": "C3548604", "aliases": ["pyrimidine nucleotide-sugar membrane transport"], "types": ["T043"], "canonical_name": "pyrimidine nucleotide-sugar transmembrane transport", "definition": "The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:tb]"}
{"concept_id": "C3548605", "aliases": ["purine nucleotide-sugar membrane transport"], "types": ["T043"], "canonical_name": "purine nucleotide-sugar transmembrane transport", "definition": "The process in which a purine nucleotide-sugar is transported across a membrane. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:tb]"}
{"concept_id": "C3548607", "aliases": [], "types": ["T043"], "canonical_name": "serine import"}
{"concept_id": "C3548610", "aliases": [], "types": ["T044"], "canonical_name": "lys-lys specific dibasic protein processing", "definition": "Any protein processing achieved by the cleavage of a peptide bond after two consecutive lysine amino acid residues within a protein. [GOC:al]"}
{"concept_id": "C3548611", "aliases": [], "types": ["T044"], "canonical_name": "lys-arg specific dibasic protein processing", "definition": "Any protein processing achieved by the cleavage of a peptide bond after a lysine-arginine amino acid residue combination within a protein. [GOC:al]"}
{"concept_id": "C3548612", "aliases": [], "types": ["T044"], "canonical_name": "dibasic protein processing", "definition": "Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein. [GOC:al]"}
{"concept_id": "C3548613", "aliases": [], "types": ["T044"], "canonical_name": "9,15,9'-tri-cis-zeta-carotene isomerase activity", "definition": "Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene. [EC:5.2.1.12]"}
{"concept_id": "C3548614", "aliases": [], "types": ["T038"], "canonical_name": "shoot organ boundary specification", "definition": "The process in which the basal boundary between the stem and both vegetative and reproductive organs are established and maintained. [PMID:18757555]"}
{"concept_id": "C3548619", "aliases": [], "types": ["T040"], "canonical_name": "arginine homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of arginine within an organism or cell. [GOC:tb]"}
{"concept_id": "C3548620", "aliases": [], "types": ["T040"], "canonical_name": "histidine homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of histidine within an organism or cell. [GOC:tb]"}
{"concept_id": "C3548621", "aliases": [], "types": ["T040"], "canonical_name": "lysine homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of lysine within an organism or cell. [GOC:tb]"}
{"concept_id": "C3548622", "aliases": [], "types": ["T040"], "canonical_name": "ornithine homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of ornithine within an organism or cell. [GOC:tb]"}
{"concept_id": "C3548623", "aliases": [], "types": ["T040"], "canonical_name": "glutamate homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell. [GOC:tb]"}
{"concept_id": "C3548624", "aliases": [], "types": ["T040"], "canonical_name": "threonine homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of threonine within an organism or cell. [GOC:tb]"}
{"concept_id": "C3548625", "aliases": [], "types": ["T040"], "canonical_name": "aspartate homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of aspartate within an organism or cell. [GOC:tb]"}
{"concept_id": "C3548629", "aliases": ["vacuolar aspartate import"], "types": ["T043"], "canonical_name": "aspartate transmembrane import into vacuole", "definition": "The directed movement of aspartate into the vacuole across the vacuolar membrane. [GOC:tb]"}
{"concept_id": "C3548630", "aliases": ["lithium ion import", "lithium ion uptake"], "types": ["T044"], "canonical_name": "lithium ion transmembrane transport", "definition": "The directed movement of lithium ions across a membrane. [GOC:tb]"}
{"concept_id": "C3548631", "aliases": [], "types": ["T038"], "canonical_name": "cotyledon boundary formation", "definition": "The process in which boundaries between a cotyledon and the surrounding tissue are established and maintained. [GOC:tb]"}
{"concept_id": "C3548633", "aliases": [], "types": ["T038"], "canonical_name": "phloem glucosinolate loading", "definition": "The process of loading glucosinolates into the sieve tube or companion cell of the phloem for long distance transport from source to sink. [PMID:22864417]"}
{"concept_id": "C3548634", "aliases": ["glucosinolate:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "glucosinolate:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in). [PMID:22864417]"}
{"concept_id": "C3548635", "aliases": [], "types": ["T044"], "canonical_name": "glycerol-3-phosphate 2-O-acyltransferase activity", "definition": "Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate. [EC:2.3.1.198]"}
{"concept_id": "C3548636", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of nematode larval development, heterochronic", "definition": "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and decreases the rate at which this time point is reached. [PMID:17550772]"}
{"concept_id": "C3548637", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of nematode larval development, heterochronic", "definition": "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and increases the rate at which this time point is reached. [PMID:17550772]"}
{"concept_id": "C3548638", "aliases": [], "types": ["T040"], "canonical_name": "regulation of nematode larval development, heterochronic", "definition": "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached. [PMID:17550772]"}
{"concept_id": "C3548639", "aliases": ["trehalose catabolic process in response to heat stress"], "types": ["T044"], "canonical_name": "trehalose catabolism in response to heat stress", "definition": "The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548640", "aliases": ["trehalose biosynthetic process in response to heat stress"], "types": ["T044"], "canonical_name": "trehalose biosynthesis in response to heat stress", "definition": "The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548641", "aliases": ["abscisic acid transporter activity"], "types": ["T044"], "canonical_name": "abscisic acid transmembrane transporter activity", "definition": "Enables the transfer of abscisic acid from one side of a membrane to the other. [GOC:tb]"}
{"concept_id": "C3548642", "aliases": [], "types": ["T044"], "canonical_name": "tetraketide alpha-pyrone synthase activity", "definition": "Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A . [MetaCyc:RXN-12183, PMID:21193570]"}
{"concept_id": "C3548643", "aliases": ["(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming)"], "types": ["T044"], "canonical_name": "camelliol C synthase activity", "definition": "Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C. [GOC:tb, PMID:17985917]"}
{"concept_id": "C3548644", "aliases": [], "types": ["T042"], "canonical_name": "socket cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support. [GOC:tb]"}
{"concept_id": "C3548645", "aliases": [], "types": ["T043"], "canonical_name": "leaf pavement cell development", "definition": "The process whose specific outcome is the progression of an leaf pavement cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a leaf pavement cell fate. [GOC:tb]"}
{"concept_id": "C3548646", "aliases": ["protein localization in nuclear envelope"], "types": ["T043"], "canonical_name": "protein localization to nuclear envelope", "definition": "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. [GOC:tb]"}
{"concept_id": "C3548647", "aliases": ["oleoyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "oleoyl-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA. [GOC:al, PMID:18071249]"}
{"concept_id": "C3548648", "aliases": ["palmitoyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "palmitoyl-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA. [GOC:al, PMID:18071249]"}
{"concept_id": "C3548649", "aliases": ["myristoyl-CoA synthetase activity"], "types": ["T044"], "canonical_name": "myristoyl-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA. [GOC:al, PMID:18071249]"}
{"concept_id": "C3548650", "aliases": ["alkyl caffeate ester anabolism", "alkyl caffeate ester synthesis", "alkyl caffeate ester formation", "alkyl caffeate ester biosynthesis"], "types": ["T044"], "canonical_name": "alkyl caffeate ester biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate. [GOC:pz]"}
{"concept_id": "C3548651", "aliases": [], "types": ["T044"], "canonical_name": "caffeoyl-CoA: alcohol caffeoyl transferase activity", "definition": "Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA. [GOC:pz]"}
{"concept_id": "C3548652", "aliases": [], "types": ["T043"], "canonical_name": "detection of endogenous biotic stimulus", "definition": "The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548653", "aliases": [], "types": ["T039"], "canonical_name": "perianth development", "definition": "The process whose specific outcome is the progression of the perianth over time, from its formation to the mature structure. The perianth is a collective phyllome structure composed of two or more petals, sepals, or tepals. [GOC:tb, PO:0009058]"}
{"concept_id": "C3548654", "aliases": [], "types": ["T043"], "canonical_name": "actin filament bundle convergence", "definition": "A process of actin filament bundle distribution that results in the compaction of actin filaments. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548655", "aliases": [], "types": ["T044"], "canonical_name": "phytochelatin-metal-sulfur complex formation", "definition": "A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex. [GOC:tb]"}
{"concept_id": "C3548656", "aliases": [], "types": ["T044"], "canonical_name": "phytochelatin-metal complex formation", "definition": "A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex. [GOC:tb]"}
{"concept_id": "C3548657", "aliases": ["thiamine pyrophosphate transporter activity", "thiamine diphosphate transporter activity"], "types": ["T044"], "canonical_name": "thiamine pyrophosphate transmembrane transporter activity", "definition": "Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other. [GOC:tb]"}
{"concept_id": "C3548658", "aliases": [], "types": ["T042"], "canonical_name": "embryonic meristem initiation", "definition": "Initiation of a region of tissue in a plant embryo that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation. [GOC:tb]"}
{"concept_id": "C3548659", "aliases": ["G-protein coupled receptor signaling pathway involved in heart process", "GPCR signaling pathway involved in heart process", "G-protein coupled receptor signalling pathway involved in heart process", "GPCR signaling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "G protein-coupled receptor signaling pathway involved in heart process", "definition": "An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]"}
{"concept_id": "C3548660", "aliases": ["adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate", "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of funny current", "G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate via inhibition of adenylate cyclase activity", "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of If channel"], "types": ["T044"], "canonical_name": "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate", "definition": "An adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3548661", "aliases": ["endothelin receptor signalling pathway involved in heart process"], "types": ["T044"], "canonical_name": "endothelin receptor signaling pathway involved in heart process", "definition": "An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]"}
{"concept_id": "C3548662", "aliases": [], "types": ["T044"], "canonical_name": "endothelin receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10977869]"}
{"concept_id": "C3548663", "aliases": ["cardiac angiotensin receptor signaling pathway via activation of PLC", "phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process", "angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process", "Gq-coupled angiotensin receptor signaling pathway involved in heart process", "PLC-activating angiotensin receptor signaling pathway involved in heart process"], "types": ["T044"], "canonical_name": "phospholipase C-activating angiotensin-activated signaling pathway involved in heart process", "definition": "An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]"}
{"concept_id": "C3548664", "aliases": ["angiotensin receptor signaling pathway involved in heart process", "angiotensin-mediated signaling pathway involved in heart process", "angiotensin receptor signalling pathway involved in heart process"], "types": ["T044"], "canonical_name": "angiotensin-activated signaling pathway involved in heart process", "definition": "An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]"}
{"concept_id": "C3548665", "aliases": ["phospholipase C-activating angiotensin-mediated signaling pathway", "phospholipase C-activating angiotensin receptor signaling pathway", "Gq-coupled angiotensin receptor signaling pathway", "angiotensin-mediated signaling pathway via activation of phospholipase C", "PLC-activating angiotensin receptor signaling pathway"], "types": ["T044"], "canonical_name": "phospholipase C-activating angiotensin-activated signaling pathway", "definition": "A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3548666", "aliases": ["G-inhibitory-coupled Beta2AR signaling pathway involved in heart process", "Gi-coupled Beta2-AR signaling pathway involved in heart process", "Gi-coupled adrenergic receptor signaling pathway involved in heart process", "cardiac adrenergic receptor signaling pathway via inhibition of adenylate cyclase activity"], "types": ["T044"], "canonical_name": "adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process", "definition": "An adenylate cyclase-inhibiting adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541]"}
{"concept_id": "C3548667", "aliases": ["muscarinic receptor signaling pathway involved in activation of IKACH", "positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling"], "types": ["T043"], "canonical_name": "positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate", "definition": "A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel]"}
{"concept_id": "C3548668", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction", "definition": "An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction. [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118]"}
{"concept_id": "C3548669", "aliases": ["gap junction channel activity involved in atrial cardiomyocyte-atrioventricular node cell electrical coupling"], "types": ["T044"], "canonical_name": "gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling", "definition": "A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3548670", "aliases": ["muscarinic receptor signalling pathway involved in negative regulation of heart rate", "M2 receptor signalling pathway involved in negative regulation of heart rate", "G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate", "muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate"], "types": ["T044"], "canonical_name": "G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate", "definition": "A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel]"}
{"concept_id": "C3548671", "aliases": ["adrenergic receptor signaling pathway involved in cardiac muscle relaxation", "Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation"], "types": ["T044"], "canonical_name": "adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation", "definition": "An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541]"}
{"concept_id": "C3548672", "aliases": ["atrioventricular node to bundle of His cell signaling", "AV node cell to bundle of His cell signalling"], "types": ["T043"], "canonical_name": "AV node cell to bundle of His cell signaling", "definition": "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3548673", "aliases": ["adrenergic receptor signaling pathway involved in positive regulation of heart rate", "Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate", "adrenergic receptor signalling pathway involved in positive regulation of heart rate"], "types": ["T044"], "canonical_name": "adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate", "definition": "An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate. [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118]"}
{"concept_id": "C3548674", "aliases": ["adrenergic receptor signaling pathway involved in heart process", "adrenergic receptor signalling pathway involved in heart process"], "types": ["T044"], "canonical_name": "adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process", "definition": "The series of molecular signals beginning with a G protein-coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, to activate adenylate cyclase, which contributes to a circulatory system process carried out by the heart. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3548676", "aliases": [], "types": ["T040"], "canonical_name": "diffuse secondary thickening", "definition": "Lateral growth of the older parts of a stem that occurs when the central parenchyma cells and the not yet fully differentiated fiber cells of the bundle sheaths continue to undergo cell division and expansion for a long period of time, leading to an increase in girth of the stem. [GOC:dhl]"}
{"concept_id": "C3548677", "aliases": [], "types": ["T040"], "canonical_name": "primary thickening", "definition": "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from the activity of a primary thickening meristem. [ISBN:0471245208, JSTOR:4354165, PO:0005039, PO:0025004]"}
{"concept_id": "C3548678", "aliases": [], "types": ["T040"], "canonical_name": "secondary thickening", "definition": "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of tissue from a secondary thickening meristem. [JSTOR:4354165, PO:0025004, PO:0025414]"}
{"concept_id": "C3548679", "aliases": [], "types": ["T040"], "canonical_name": "lateral growth", "definition": "Growth of a plant axis (shoot axis or root) that originates from a lateral meristem. [PO:0020145]"}
{"concept_id": "C3548680", "aliases": [], "types": ["T040"], "canonical_name": "primary growth", "definition": "Growth of a plant structure from the time of its initiation by an apical meristem until its expansion is completed. [ISBN:0471245208]"}
{"concept_id": "C3548681", "aliases": ["RNA-directed DNA methylation", "RdDM"], "types": ["T045"], "canonical_name": "gene silencing by RNA-directed DNA methylation", "definition": "A small RNA-based epigenetic gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism. [PMID:21420348]"}
{"concept_id": "C3548682", "aliases": ["viral entry into host nucleus", "viral import into host nucleus"], "types": ["T043"], "canonical_name": "viral penetration into host nucleus", "definition": "The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid. [PMID:22929056, VZ:989]"}
{"concept_id": "C3548683", "aliases": ["establishment of plasmid latency"], "types": ["T038"], "canonical_name": "establishment of episomal latency", "definition": "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a distinct genetic entity. [GOC:jl]"}
{"concept_id": "C3548685", "aliases": ["viral genome transport to host cell nucleus", "transport of viral material to nucleus", "cytoplasmic inwards viral transport"], "types": ["T043"], "canonical_name": "transport of viral material towards nucleus", "definition": "The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane. [GOC:bf, GOC:jl, VZ:990]"}
{"concept_id": "C3548686", "aliases": ["establishment of linear plasmid latency", "establishment of latency as a linear plasmid"], "types": ["T038"], "canonical_name": "establishment of latency as a linear episome", "definition": "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as linear structure. [GOC:jl]"}
{"concept_id": "C3548687", "aliases": ["establishment of circular plasmid latency", "establishment of latency as a circular plasmid"], "types": ["T038"], "canonical_name": "establishment of latency as a circular episome", "definition": "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a circular structure. [GOC:jl]"}
{"concept_id": "C3548688", "aliases": ["microtubule-dependent intracellular transport of viral material to nucleus"], "types": ["T043"], "canonical_name": "microtubule-dependent intracellular transport of viral material towards nucleus", "definition": "The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules. [UniProtKB-KW:KW-1177, VZ:983]"}
{"concept_id": "C3548689", "aliases": ["actin-dependent intracellular transport of viral material"], "types": ["T043"], "canonical_name": "actin-dependent intracellular transport of virus", "definition": "The directed movement of a virus, or part of a virus, within the host cell cytoplasm via the host's actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions. [UniProtKB-KW:KW-1178, VZ:991]"}
{"concept_id": "C3548690", "aliases": [], "types": ["T043"], "canonical_name": "microtubule-dependent intracellular transport of viral material", "definition": "The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus. [VZ:983]"}
{"concept_id": "C3548691", "aliases": ["entry of viral genome into host nucleus via attachment of capsid to nuclear pore complex and release of genome into nucleoplasm"], "types": ["T045"], "canonical_name": "entry of viral genome into host nucleus via retainment of capsid in nuclear pore complex and release of genome into nucleoplasm", "definition": "Viral penetration into the host nucleus where a viral capsid enters the host nuclear pore complex (NPC) but remains attached to the pore on the nuclear side. The capsid then disassembles, releasing the viral genome into the nucleoplasm. [PMID:22929056, VZ:989]"}
{"concept_id": "C3548692", "aliases": [], "types": ["T045"], "canonical_name": "entry of viral genome into host nucleus via docking of viral capsid to the nuclear pore complex and injection of viral genome", "definition": "Viral penetration into the host nucleus where the where a viral capsid docks on the cytoplasmic side of the nuclear pore complex (NPC) and ejects the viral genome through the pore into the nucleoplasm. [PMID:22929056, VZ:989]"}
{"concept_id": "C3548693", "aliases": ["entry of viral genome into host nucleus via cellular importin transport through the nuclear pore complex"], "types": ["T045"], "canonical_name": "entry of viral genome into host nucleus through nuclear pore complex via importin", "definition": "Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery. [PMID:22929056, VZ:989]"}
{"concept_id": "C3548694", "aliases": [], "types": ["T040"], "canonical_name": "entry of intact viral capsid into host nucleus through nuclear pore complex", "definition": "Viral penetration into the host nucleus where a viral capsid passes intact through the host nuclear pore complex (NPC). [PMID:22929056, VZ:989]"}
{"concept_id": "C3548695", "aliases": ["viral entry into host cell via macropinocytosis followed by macropinosomal membrane permeabilization"], "types": ["T043"], "canonical_name": "macropinosomal membrane permeabilization involved in viral entry into host cell", "definition": "Induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm. [GOC:bf, GOC:jl]"}
{"concept_id": "C3548696", "aliases": ["viral entry into host cell via macropinocytosis followed by membrane fusion with the host macropinosome membrane", "viral entry into host cell via macropinocytosis followed by membrane fusion with the endosome membrane"], "types": ["T043"], "canonical_name": "fusion of virus membrane with host macropinosome membrane", "definition": "Fusion of a viral membrane with a host macropinosome membrane, that occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents into the host cell cytoplasm. [GOC:bf, GOC:jl]"}
{"concept_id": "C3548697", "aliases": [], "types": ["T043"], "canonical_name": "endosome membrane permeabilization involved in viral entry into host cell", "definition": "Induction of endosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus through the endosomal pathway, and results in delivery of the virus contents into the host cell cytoplasm. [GOC:bf, GOC:jl]"}
{"concept_id": "C3548698", "aliases": ["viral entry into host cell via caveolae-mediated endocytosis followed by membrane fusion with the endosome membrane"], "types": ["T043"], "canonical_name": "viral penetration via endocytosis followed by caveolae-mediated membrane fusion with the endosome membrane"}
{"concept_id": "C3548699", "aliases": ["centromere clustering at the nuclear periphery"], "types": ["T045"], "canonical_name": "centromere clustering at the mitotic nuclear envelope"}
{"concept_id": "C3548700", "aliases": ["kinetochore localization", "kinetochore localisation", "establishment and maintenance of kinetochore localization"], "types": ["T043"], "canonical_name": "centromere localization", "definition": "A cellular localization process in which a centromere/kinetochore is transported to, or maintained in, a specific location. [GOC:mah]"}
{"concept_id": "C3548701", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to reversine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus. [GOC:mah]"}
{"concept_id": "C3548702", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to hesperadin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus. [GOC:mah]"}
{"concept_id": "C3548703", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to carbendazim", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus. [GOC:mah]"}
{"concept_id": "C3548704", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to capsazepine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus. [GOC:mah]"}
{"concept_id": "C3548705", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to GW 7647", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus. [GOC:mah]"}
{"concept_id": "C3548706", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to topoisomerase inhibitor", "definition": "Any process that results in a change in state or activity of a (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus. [GOC:mah]"}
{"concept_id": "C3548707", "aliases": [], "types": ["T043"], "canonical_name": "response to topoisomerase inhibitor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus. [GOC:mah]"}
{"concept_id": "C3548708", "aliases": ["cellular response to CPT"], "types": ["T043"], "canonical_name": "cellular response to camptothecin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus. [GOC:mah]"}
{"concept_id": "C3548709", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to paraquat", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus. [GOC:mah]"}
{"concept_id": "C3548710", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to benomyl", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus. [GOC:mah]"}
{"concept_id": "C3548711", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to purvalanol A", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus. [GOC:mah]"}
{"concept_id": "C3548712", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to glutathione", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus. [GOC:mah]"}
{"concept_id": "C3548713", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to rapamycin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus. [GOC:TermGenie]"}
{"concept_id": "C3548714", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to L-thialysine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus. [GOC:mah]"}
{"concept_id": "C3548715", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to leptomycin B", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus. [GOC:mah]"}
{"concept_id": "C3548716", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cytochalasin B", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus. [GOC:mah]"}
{"concept_id": "C3548717", "aliases": ["cellular response to FK506", "cellular response to tacrolimus hydrate"], "types": ["T043"], "canonical_name": "cellular response to tacrolimus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus (FK506) stimulus. [GOC:mah]"}
{"concept_id": "C3548718", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chloramphenicol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus. [GOC:mah]"}
{"concept_id": "C3548719", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to tetracycline", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus. [GOC:mah]"}
{"concept_id": "C3548720", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to antimycin A", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus. [GOC:mah]"}
{"concept_id": "C3548721", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to trichodermin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus. [GOC:mah]"}
{"concept_id": "C3548722", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to erythromycin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus. [GOC:mah]"}
{"concept_id": "C3548723", "aliases": ["SAGA complex recruitment", "SAGA complex localization to promoter"], "types": ["T045"], "canonical_name": "SAGA complex localization to transcription regulatory region", "definition": "Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene. [GOC:mah]"}
{"concept_id": "C3548724", "aliases": ["protein localisation to cell division site"], "types": ["T043"], "canonical_name": "protein localization to cell division site", "definition": "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division. [GOC:mah, PMID:19756689]"}
{"concept_id": "C3548725", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to anisomycin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. [GOC:mah]"}
{"concept_id": "C3548726", "aliases": [], "types": ["T043"], "canonical_name": "response to anisomycin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. [GOC:mah]"}
{"concept_id": "C3548727", "aliases": ["cellular response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide"], "types": ["T043"], "canonical_name": "cellular response to diamide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus. [GOC:mah]"}
{"concept_id": "C3548728", "aliases": ["response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide"], "types": ["T043"], "canonical_name": "response to diamide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus. [GOC:mah]"}
{"concept_id": "C3548729", "aliases": ["cellular response to t-BOOH", "cellular response to 2-methyl-prop-2-yl-hydroperoxide"], "types": ["T043"], "canonical_name": "cellular response to tert-butyl hydroperoxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus. [GOC:mah]"}
{"concept_id": "C3548730", "aliases": ["response to 2-methyl-prop-2-yl-hydroperoxide", "response to t-BOOH"], "types": ["T043"], "canonical_name": "response to tert-butyl hydroperoxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus. [GOC:mah]"}
{"concept_id": "C3548731", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to staurosporine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus. [GOC:mah]"}
{"concept_id": "C3548732", "aliases": [], "types": ["T043"], "canonical_name": "response to staurosporine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus. [GOC:mah]"}
{"concept_id": "C3548733", "aliases": ["cellular response to calcium starvation"], "types": ["T043"], "canonical_name": "cellular response to calcium ion starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions. [GOC:mah]"}
{"concept_id": "C3548734", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to papulacandin B", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus. [GOC:mah]"}
{"concept_id": "C3548735", "aliases": [], "types": ["T043"], "canonical_name": "response to papulacandin B", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus. [GOC:mah]"}
{"concept_id": "C3548736", "aliases": ["cellular response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride", "cellular response to crystal violet"], "types": ["T043"], "canonical_name": "cellular response to Gentian violet", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus. [GOC:mah]"}
{"concept_id": "C3548737", "aliases": ["response to crystal violet", "response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride"], "types": ["T043"], "canonical_name": "response to Gentian violet", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus. [GOC:mah]"}
{"concept_id": "C3548738", "aliases": ["cellular response to carbonyl cyanide m-chlorophenyl hydrazone"], "types": ["T043"], "canonical_name": "cellular response to CCCP", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus. [GOC:mah]"}
{"concept_id": "C3548739", "aliases": ["response to carbonyl cyanide m-chlorophenyl hydrazone"], "types": ["T043"], "canonical_name": "response to CCCP", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus. [GOC:mah]"}
{"concept_id": "C3548740", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to 4-nitroquinoline N-oxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus. [GOC:mah]"}
{"concept_id": "C3548741", "aliases": [], "types": ["T043"], "canonical_name": "response to 4-nitroquinoline N-oxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus. [GOC:mah]"}
{"concept_id": "C3548742", "aliases": ["response to 3-amino-1,2,4-triazole"], "types": ["T043"], "canonical_name": "response to amitrole", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus. [GOC:mah]"}
{"concept_id": "C3548743", "aliases": ["cellular response to DTT", "cellular response to 1,4-dithiothreitol"], "types": ["T043"], "canonical_name": "cellular response to dithiothreitol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus. [GOC:mah]"}
{"concept_id": "C3548744", "aliases": ["response to DTT", "response to 1,4-dithiothreitol"], "types": ["T043"], "canonical_name": "response to dithiothreitol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus. [GOC:mah]"}
{"concept_id": "C3548745", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cisplatin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus. [GOC:mah]"}
{"concept_id": "C3548746", "aliases": [], "types": ["T043"], "canonical_name": "response to cisplatin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus. [GOC:mah]"}
{"concept_id": "C3548747", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to actinomycin D", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus. [GOC:mah]"}
{"concept_id": "C3548748", "aliases": [], "types": ["T043"], "canonical_name": "response to actinomycin D", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus. [GOC:mah]"}
{"concept_id": "C3548749", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to selenite ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus. [GOC:mah]"}
{"concept_id": "C3548750", "aliases": [], "types": ["T043"], "canonical_name": "response to selenite ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus. [GOC:mah]"}
{"concept_id": "C3548751", "aliases": ["cellular response to TBZ"], "types": ["T043"], "canonical_name": "cellular response to thiabendazole", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus. [GOC:mah]"}
{"concept_id": "C3548752", "aliases": ["response to TBZ"], "types": ["T043"], "canonical_name": "response to thiabendazole", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus. [GOC:mah]"}
{"concept_id": "C3548753", "aliases": ["cellular response to HU"], "types": ["T043"], "canonical_name": "cellular response to hydroxyurea", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus. [GOC:mah]"}
{"concept_id": "C3548754", "aliases": ["response to HU"], "types": ["T043"], "canonical_name": "response to hydroxyurea", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus. [GOC:mah]"}
{"concept_id": "C3548755", "aliases": ["cellular response to glucitol"], "types": ["T043"], "canonical_name": "cellular response to sorbitol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus. [GOC:mah]"}
{"concept_id": "C3548756", "aliases": ["response to glucitol"], "types": ["T043"], "canonical_name": "response to sorbitol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus. [GOC:mah]"}
{"concept_id": "C3548757", "aliases": ["cellular response to SDS"], "types": ["T043"], "canonical_name": "cellular response to sodium dodecyl sulfate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus. [GOC:mah]"}
{"concept_id": "C3548758", "aliases": ["response to SDS"], "types": ["T043"], "canonical_name": "response to sodium dodecyl sulfate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus. [GOC:mah]"}
{"concept_id": "C3548759", "aliases": ["cellular response to 2-sulfanylethanol"], "types": ["T043"], "canonical_name": "cellular response to mercaptoethanol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus. [GOC:mah]"}
{"concept_id": "C3548760", "aliases": ["response to 2-sulfanylethanol"], "types": ["T043"], "canonical_name": "response to mercaptoethanol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus. [GOC:mah]"}
{"concept_id": "C3548761", "aliases": ["cellular response to MMS"], "types": ["T043"], "canonical_name": "cellular response to methyl methanesulfonate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus. [GOC:mah]"}
{"concept_id": "C3548762", "aliases": ["response to MMS"], "types": ["T043"], "canonical_name": "response to methyl methanesulfonate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus. [GOC:mah]"}
{"concept_id": "C3548763", "aliases": ["cellular response to bismuth ion"], "types": ["T043"], "canonical_name": "cellular response to bismuth", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus. [GOC:mah]"}
{"concept_id": "C3548764", "aliases": ["response to bismuth ion"], "types": ["T043"], "canonical_name": "response to bismuth", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus. [GOC:mah]"}
{"concept_id": "C3548765", "aliases": ["protein localisation to cortical microtubule cytoskeleton"], "types": ["T043"], "canonical_name": "protein localization to cortical microtubule cytoskeleton", "definition": "A process in which a protein is transported to, or maintained at, a location within the cortical microtubule cytoskeleton. [GOC:mah]"}
{"concept_id": "C3548766", "aliases": ["protein localisation to microtubule cytoskeleton"], "types": ["T043"], "canonical_name": "protein localization to microtubule cytoskeleton", "definition": "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. [GOC:mah]"}
{"concept_id": "C3548767", "aliases": ["protein localisation to cell cortex"], "types": ["T043"], "canonical_name": "protein localization to cell cortex", "definition": "A process in which a protein is transported to, or maintained in, the cell cortex. [GOC:mah]"}
{"concept_id": "C3548769", "aliases": ["intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator"], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway by p53 class mediator", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. [GOC:mah, GOC:mtg_apoptosis]"}
{"concept_id": "C3548770", "aliases": ["regulation of bacterial-type flagellum cell motility by regulation of motor speed"], "types": ["T043"], "canonical_name": "regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed", "definition": "A process that modulates flagellum-dependent motility in bacteria by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein. [GOC:cilia, GOC:jl, PMID:20371342]"}
{"concept_id": "C3548771", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of zinc ion transmembrane import", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of zinc ion import. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3548772", "aliases": [], "types": ["T044"], "canonical_name": "regulation of zinc ion transmembrane import", "definition": "Any process that modulates the frequency, rate or extent of zinc ion import. [GOC:BHF, GOC:mah]"}
{"concept_id": "C3548773", "aliases": ["actin filament bundle convergence involved in cytokinetic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "actomyosin contractile ring assembly actin filament bundle convergence", "definition": "A process of actin filament bundle distribution that occurs in the context of assembling an actomyosin contractile ring during cytokinesis, and that results in the compaction of actin filaments into a tight ring. [GOC:mah, PMID:19713940]"}
{"concept_id": "C3548774", "aliases": ["actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "actomyosin contractile ring actin filament bundle assembly", "definition": "A process of actin filament bundle formation that occurs in the context of assembling an actomyosin contractile ring during cytokinesis. [GOC:mah, PMID:19713940]"}
{"concept_id": "C3548775", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to cilium", "definition": "A process in which a protein is transported to, or maintained in, a location within a cilium. [GOC:dph]"}
{"concept_id": "C3548776", "aliases": [], "types": ["T043"], "canonical_name": "centriole elongation", "definition": "The centrosome organization process by which a centriole increases in length as part of the process of replication. [GOC:dph, PMID:21576394]"}
{"concept_id": "C3548777", "aliases": [], "types": ["T043"], "canonical_name": "asymmetric protein localization to new mitotic spindle pole body", "definition": "Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically. [GOC:dph, GOC:vw]"}
{"concept_id": "C3548778", "aliases": [], "types": ["T044"], "canonical_name": "CDP phosphorylation", "definition": "The process of introducing a phosphate group into CDP to produce a CTP. [PMID:7499258]"}
{"concept_id": "C3548779", "aliases": ["cyclic-GMP-AMP binding"], "types": ["T044"], "canonical_name": "cyclic GMP-AMP binding", "definition": "Binding to cyclic GMP-AMP (cGAMP) nucleotide. [PMID:23258412]"}
{"concept_id": "C3548781", "aliases": [], "types": ["T045"], "canonical_name": "DNA topoisomerase II activity"}
{"concept_id": "C3548782", "aliases": [], "types": ["T045"], "canonical_name": "cyclic threonylcarbamoyladenosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. [PMID:23242255]"}
{"concept_id": "C3548783", "aliases": [], "types": ["T044"], "canonical_name": "tRNA threonylcarbamoyladenosine dehydratase", "definition": "Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A. [GOC:dph, PMID:23242255]"}
{"concept_id": "C3548784", "aliases": [], "types": ["T043"], "canonical_name": "early endosome to recycling endosome transport", "definition": "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes. [GOC:dph, GOC:kmv, PMID:21474295]"}
{"concept_id": "C3548785", "aliases": ["cyclic-GMP-AMP synthase activity"], "types": ["T044"], "canonical_name": "cyclic GMP-AMP synthase activity", "definition": "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP. [PMID:23258413]"}
{"concept_id": "C3548787", "aliases": [], "types": ["T026"], "canonical_name": "outer plaque of mitotic spindle pole body", "definition": "One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm. [GOC:dph]"}
{"concept_id": "C3548788", "aliases": [], "types": ["T026"], "canonical_name": "intermediate layer of mitotic spindle pole body", "definition": "Structure between the central and outer plaques of the mitotic spindle pole body. [GOC:dph]"}
{"concept_id": "C3548789", "aliases": [], "types": ["T026"], "canonical_name": "inner plaque of mitotic spindle pole body", "definition": "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus. [GOC:dph, GOC:vw]"}
{"concept_id": "C3548790", "aliases": [], "types": ["T026"], "canonical_name": "half bridge of mitotic spindle pole body", "definition": "Structure adjacent to the plaques of the mitotic spindle pole body. [GOC:dph]"}
{"concept_id": "C3548791", "aliases": [], "types": ["T026"], "canonical_name": "central plaque of mitotic spindle pole body", "definition": "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body. [GOC:dph]"}
{"concept_id": "C3548792", "aliases": [], "types": ["T043"], "canonical_name": "asymmetric protein localization to old or new spindle pole body", "definition": "Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically. [GOC:dph, PMID:22119525]"}
{"concept_id": "C3548798", "aliases": ["high affinity fructose transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity fructose transmembrane transporter activity", "definition": "Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:dph, PMID:10735857]"}
{"concept_id": "C3548799", "aliases": [], "types": ["T043"], "canonical_name": "memory T cell proliferation", "definition": "The expansion of a memory T cell population by cell division. [GOC:dph, PMID:14647273]"}
{"concept_id": "C3548800", "aliases": [], "types": ["T038"], "canonical_name": "hematopoietic stem cell homeostasis", "definition": "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. [GOC:dph, PMID:21508411]"}
{"concept_id": "C3548801", "aliases": [], "types": ["T043"], "canonical_name": "response to irinotecan", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus. [GOC:dph]"}
{"concept_id": "C3548802", "aliases": [], "types": ["T043"], "canonical_name": "response to TNF agonist", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus. [GOC:dph]"}
{"concept_id": "C3548803", "aliases": [], "types": ["T043"], "canonical_name": "response to asparaginase", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus. [GOC:dph]"}
{"concept_id": "C3548804", "aliases": [], "types": ["T040"], "canonical_name": "response to platelet aggregation inhibitor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet aggregation inhibitor stimulus. [GOC:dph]"}
{"concept_id": "C3548805", "aliases": [], "types": ["T043"], "canonical_name": "response to aromatase inhibitor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus. [GOC:dph]"}
{"concept_id": "C3548806", "aliases": [], "types": ["T040"], "canonical_name": "response to anticoagulant", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus. [GOC:dph]"}
{"concept_id": "C3548807", "aliases": [], "types": ["T045"], "canonical_name": "cytosolic valyl-tRNA aminoacylation", "definition": "The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. [GOC:dph]"}
{"concept_id": "C3548808", "aliases": [], "types": ["T026"], "canonical_name": "phagolysosome membrane", "definition": "The lipid bilayer surrounding a phagolysosome. [GOC:dph, PMID:22073313]"}
{"concept_id": "C3548809", "aliases": [], "types": ["T044"], "canonical_name": "murein tripeptide carboxypeptidase activity", "definition": "Catalysis of the reaction L-Ala-gamma-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-gamma-D-Glu + meso-diaminopimelate. [GOC:dph, PMID:22970852]"}
{"concept_id": "C3548810", "aliases": [], "types": ["T043"], "canonical_name": "karyomere membrane fusion", "definition": "Process whereby karyomere membranes fuse during interphase to form a single lobed nucleus. [GOC:dph, PMID:2734396]"}
{"concept_id": "C3548811", "aliases": [], "types": ["T043"], "canonical_name": "karyomere assembly", "definition": "The process where the nuclear membrane engulfs condensed chromosomes to form karyomeres during M phase of the mitotic cell cycle. [GOC:dph, PMID:9732278]"}
{"concept_id": "C3548812", "aliases": ["T-helper follicular cell differentiation"], "types": ["T043"], "canonical_name": "T follicular helper cell differentiation", "definition": "The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell. [GOC:dph, PMID:21572431]"}
{"concept_id": "C3548813", "aliases": [], "types": ["T043"], "canonical_name": "regulation of type B pancreatic cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. [GOC:dph]"}
{"concept_id": "C3548814", "aliases": [], "types": ["T026"], "canonical_name": "karyomere", "definition": "A membrane-bound intermediate cleavage-stage structure of individual or groups of chromosomes that coalesces and fuses with other karyomeres to form a nucleus during interphase. Karyomere formation occurs in blastomeres undergoing rapid cell division. [GOC:dph, PMID:12734396, PMID:22863006]"}
{"concept_id": "C3548819", "aliases": [], "types": ["T044"], "canonical_name": "O-acetyl-ADP-ribose deacetylase activity", "definition": "Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate. [GOC:dph]"}
{"concept_id": "C3548820", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to lysosome", "definition": "A process in which a protein is transported to, or maintained in, a location within a lysosome. [GOC:dph]"}
{"concept_id": "C3548822", "aliases": ["L-arginine transporter activity", "arginine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "L-arginine transmembrane transporter activity", "definition": "Enables the transfer of L-arginine from one side of a membrane to the other. [GOC:dph, RHEA:32143]"}
{"concept_id": "C3548823", "aliases": [], "types": ["T038"], "canonical_name": "reproductive system development", "definition": "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. [GOC:dph]"}
{"concept_id": "C3548824", "aliases": [], "types": ["T043"], "canonical_name": "mesonephric cell migration involved in male gonad development", "definition": "The orderly movement of a cell from the mesonephros to the male gonad, contributing to its development. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548825", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal stem cell migration involved in uteric bud morphogenesis", "definition": "The orderly movement of a mesenchymal stem cell from one site to another contributing to the shaping of the ureteric bud. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [GOC:dph, GOC:tb]"}
{"concept_id": "C3548826", "aliases": ["integral to muscle cell projection membrane"], "types": ["T026"], "canonical_name": "integral component of muscle cell projection membrane", "definition": "The component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:dph, GOC:tb]"}
{"concept_id": "C3548827", "aliases": [], "types": ["T043"], "canonical_name": "Golgi calcium ion export"}
{"concept_id": "C3548828", "aliases": [], "types": ["T043"], "canonical_name": "retrotrapezoid nucleus neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus. [GOC:dph]"}
{"concept_id": "C3548829", "aliases": [], "types": ["T042"], "canonical_name": "retrotrapezoid nucleus development", "definition": "The progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration. [GOC:dph]"}
{"concept_id": "C3548830", "aliases": [], "types": ["T043"], "canonical_name": "trophoblast cell migration", "definition": "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst. [GOC:dph]"}
{"concept_id": "C3548831", "aliases": [], "types": ["T043"], "canonical_name": "olfactory bulb tufted cell development", "definition": "The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dph]"}
{"concept_id": "C3548832", "aliases": [], "types": ["T043"], "canonical_name": "cardiac pacemaker cell fate commitment", "definition": "The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]"}
{"concept_id": "C3548833", "aliases": [], "types": ["T043"], "canonical_name": "cardiac pacemaker cell development", "definition": "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]"}
{"concept_id": "C3548834", "aliases": [], "types": ["T043"], "canonical_name": "cardiac pacemaker cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]"}
{"concept_id": "C3548835", "aliases": [], "types": ["T043"], "canonical_name": "clearance of cells from fusion plate by apoptotic process", "definition": "Any apoptotic process that contributes to the shaping of the semicircular canal by removing cells in the fusion plate, forming the loops of the canals. [GOC:dph, GOC:mtg_apoptosis, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C3548836", "aliases": [], "types": ["T043"], "canonical_name": "glycogen cell differentiation involved in embryonic placenta development", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer. [GOC:dph, PMID:16269175]"}
{"concept_id": "C3548837", "aliases": [], "types": ["T040"], "canonical_name": "branching involved in labyrinthine layer morphogenesis", "definition": "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. [GOC:dph, PMID:16916377]"}
{"concept_id": "C3548838", "aliases": ["extracellular signal-induced necroptosis"], "types": ["T043"], "canonical_name": "activation of necroptosis by extracellular signals"}
{"concept_id": "C3548839", "aliases": ["establishment of necroptosis of activated-T cells"], "types": ["T043"], "canonical_name": "activation of necroptosis of activated-T cells"}
{"concept_id": "C3548840", "aliases": [], "types": ["T039"], "canonical_name": "modulation by virus of syncytium formation via plasma membrane fusion", "definition": "The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:dph]"}
{"concept_id": "C3548841", "aliases": ["response to lipoprotein particle stimulus"], "types": ["T043"], "canonical_name": "response to lipoprotein particle", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. [GOC:BHF, GOC:rl]"}
{"concept_id": "C3548842", "aliases": [], "types": ["T044"], "canonical_name": "norspermine:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide. [MetaCyc:RXN-10464]"}
{"concept_id": "C3548844", "aliases": ["inhibition of dopamine import involved in synaptic transmission"], "types": ["T043"], "canonical_name": "inhibition of dopamine uptake involved in synaptic transmission", "definition": "Any process that prevents the activation of the directed movement of dopamine into a cell. [GOC:ai]"}
{"concept_id": "C3548845", "aliases": ["up regulation of dopamine uptake involved in synaptic transmission", "upregulation of dopamine uptake involved in synaptic transmission", "positive regulation of dopamine import involved in synaptic transmission", "up-regulation of dopamine uptake involved in synaptic transmission"], "types": ["T043"], "canonical_name": "positive regulation of dopamine uptake involved in synaptic transmission", "definition": "Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell. [GOC:ai]"}
{"concept_id": "C3548846", "aliases": ["down-regulation of dopamine uptake involved in synaptic transmission", "negative regulation of dopamine import involved in synaptic transmission", "downregulation of dopamine uptake involved in synaptic transmission", "down regulation of dopamine uptake involved in synaptic transmission"], "types": ["T043"], "canonical_name": "negative regulation of dopamine uptake involved in synaptic transmission", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell. [GOC:ai]"}
{"concept_id": "C3548847", "aliases": ["regulation of dopamine import involved in synaptic transmission"], "types": ["T042"], "canonical_name": "regulation of dopamine uptake involved in synaptic transmission", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell. [GOC:ai]"}
{"concept_id": "C3548848", "aliases": ["dopamine import involved in synaptic transmission", "dopamine reuptake involved in synaptic transmission"], "types": ["T043"], "canonical_name": "dopamine uptake involved in synaptic transmission", "definition": "The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:ai]"}
{"concept_id": "C3548849", "aliases": [], "types": ["T043"], "canonical_name": "xylem vessel member cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened. [GOC:jid, PO:0002003]"}
{"concept_id": "C3548850", "aliases": [], "types": ["T040"], "canonical_name": "branching morphogenesis of an epithelial tube", "definition": "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. [GOC:dgh, GOC:dph, GOC:jid]"}
{"concept_id": "C3548851", "aliases": [], "types": ["T038"], "canonical_name": "acquisition of desiccation tolerance in seed", "definition": "The process in which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state. [GOC:jid, GOC:ki, GOC:PO_curators, ISBN:9781405139830]"}
{"concept_id": "C3548852", "aliases": ["tropomyosin-receptor-kinase signaling"], "types": ["T044"], "canonical_name": "neurotrophin TRK receptor signaling pathway", "definition": "The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor]"}
{"concept_id": "C3548854", "aliases": ["spread of virus within multicellular host", "viral spread within multicellular host", "spread of virus in multicellular host"], "types": ["T038"], "canonical_name": "transport of virus in multicellular host", "definition": "The transport of a virus between cells in a multicellular organism. The cells can be adjacent or spatially separated (e.g. in different tissues or organs). [GOC:bf, GOC:jl, ISBN:0781718325]"}
{"concept_id": "C3548855", "aliases": ["keto-D-gluconate anabolism", "keto-D-gluconate synthesis", "keto-D-gluconate formation", "keto-D-gluconate biosynthesis"], "types": ["T044"], "canonical_name": "keto-D-gluconate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose. [ISBN:0198506732]"}
{"concept_id": "C3548856", "aliases": ["up-regulation of cilium assembly", "upregulation of cilium assembly", "up regulation of cilium assembly"], "types": ["T043"], "canonical_name": "positive regulation of cilium assembly", "definition": "Any process that activates or increases the frequency, rate or extent of the formation of a cilium. [GOC:cilia, GOC:go_curators]"}
{"concept_id": "C3548857", "aliases": [], "types": ["T044"], "canonical_name": "glutamate synthase activity, NAD(P)H as acceptor", "definition": "Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+. [EC:1.4.1.13, EC:1.4.1.14]"}
{"concept_id": "C3548858", "aliases": [], "types": ["T043"], "canonical_name": "bacterial-type flagellum organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. [GOC:jl]"}
{"concept_id": "C3548859", "aliases": ["bacterial flagellum assembly"], "types": ["T043"], "canonical_name": "bacterial-type flagellum assembly", "definition": "The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. [GOC:jl]"}
{"concept_id": "C3548860", "aliases": ["intracellular signaling pathway involved in meiotic spindle checkpoint", "intracellular signaling cascade involved in meiotic spindle checkpoint", "meiotic spindle checkpoint", "intracellular signal transduction pathway involved in meiotic spindle checkpoint", "intracellular signal transduction involved in meiotic spindle checkpoint"], "types": ["T043"], "canonical_name": "meiotic spindle checkpoint signaling", "definition": "A signal transduction process that contributes to a cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic nuclear division until the spindle is correctly assembled and that the chromosomes are attached to the spindle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3548861", "aliases": ["meiotic DNA integrity checkpoint"], "types": ["T043"], "canonical_name": "meiotic DNA integrity checkpoint signaling", "definition": "A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3548862", "aliases": ["mitotic DNA damage checkpoint", "intracellular signaling cascade involved in mitotic DNA damage checkpoint", "signal transduction involved in mitotic DNA damage checkpoint"], "types": ["T045"], "canonical_name": "mitotic DNA damage checkpoint signaling", "definition": "A signal transduction process involved in mitotic DNA damage checkpoint. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3548863", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cell cycle phase transition", "definition": "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3548864", "aliases": [], "types": ["T043"], "canonical_name": "meiotic cell cycle phase transition", "definition": "The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3548865", "aliases": [], "types": ["T044"], "canonical_name": "ATPase activity, coupled to transmembrane movement of ions, rotational mechanism", "definition": "Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism. [GOC:jl]"}
{"concept_id": "C3548866", "aliases": ["NMS complex formation", "NMS complex assembly involved in kinetochore assembly", "NMS complex association involved in chromosome segregation", "KNL-1-Mis12-Ndc80 assembly", "KNL-1-Mis12-Ndc80 formation", "KMN complex interaction involved in chromosome segregation", "KMN network assembly involved in chromosome segregation", "Ndc80-MIND-Spc7 complex formation", "KMN kinetochore network assembly", "KMN kinetochore network formation", "Ndc80-MIND-Spc7 complex assembly"], "types": ["T044"], "canonical_name": "NMS complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an NMS complex. The NMS complex results from the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) and is required for kinetochore assembly. [GOC:vw, PMID:22561345]"}
{"concept_id": "C3548871", "aliases": [], "types": ["T043"], "canonical_name": "single-organism cellular process"}
{"concept_id": "C3548872", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of host neurotransmitter secretion", "definition": "Any process in which a symbiont organism negatively regulates the regulated release of a neurotransmitter from a cell in its host organism. [GOC:jl]"}
{"concept_id": "C3548873", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by symbiont of host cholinergic synaptic transmission", "definition": "Any process in which a symbiont organism negatively regulates cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism. [GOC:jl]"}
{"concept_id": "C3548874", "aliases": ["regulation by symbiont of host cholinergic synaptic transmission"], "types": ["T043"], "canonical_name": "modulation by symbiont of host cholinergic synaptic transmission", "definition": "Any process in which a symbiont organism modulates the frequency, rate or extent of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism. [GOC:jl]"}
{"concept_id": "C3548875", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation by symbiont of host synaptic transmission", "definition": "Any process in which a symbiont organism decreases the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism. [GOC:jl]"}
{"concept_id": "C3548876", "aliases": ["regulation by symbiont of host synaptic transmission"], "types": ["T040"], "canonical_name": "modulation by symbiont of host synaptic transmission", "definition": "Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism. [GOC:jl]"}
{"concept_id": "C3548880", "aliases": [], "types": ["T026"], "canonical_name": "amphisome", "definition": "Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes. [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]"}
{"concept_id": "C3548881", "aliases": ["response to human chorionic gonadotropin stimulus"], "types": ["T043"], "canonical_name": "response to human chorionic gonadotropin", "definition": "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus. [PMID:21325635]"}
{"concept_id": "C3548882", "aliases": ["cellular response to human chorionic gonadotrophin stimulus"], "types": ["T043"], "canonical_name": "cellular response to human chorionic gonadotropin stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus. [PMID:21325635]"}
{"concept_id": "C3548883", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity nickel cation transmembrane transporter activity", "definition": "Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:jl]"}
{"concept_id": "C3548885", "aliases": [], "types": ["T045"], "canonical_name": "3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing", "definition": "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA. [GOC:sart]"}
{"concept_id": "C3548889", "aliases": [], "types": ["T043"], "canonical_name": "protein transmembrane import into intracellular organelle", "definition": "The directed movement of proteins into an intracellular organelle, across a membrane. [GOC:jl]"}
{"concept_id": "C3548890", "aliases": ["envenomation resulting in modulation of sensory perception of pain in other organism", "envenomation resulting in regulation of sensory perception of pain in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of sensory perception of pain in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism. [GOC:fj, GOC:jl, PMID:23034652]"}
{"concept_id": "C3548891", "aliases": ["envenomation resulting in negative regulation of sensory perception of pain in other organism", "envenomation resulting in inhibition of sensory perception of pain in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of sensory perception of pain in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism. [GOC:fj, GOC:jl, PMID:23034652]"}
{"concept_id": "C3548892", "aliases": ["negative regulation of sensory perception of pain in other organism", "inhibition of sensory perception of pain in another organism"], "types": ["T038"], "canonical_name": "negative regulation of sensory perception of pain in another organism", "definition": "A process that negatively regulates the sensory perception of pain in a different organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3548893", "aliases": ["positive regulation of acid-sensing ion channel in other organism", "positive regulation of ASIC channel in other organism"], "types": ["T038"], "canonical_name": "positive regulation of acid-sensing ion channel in another organism", "definition": "Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism. [GOC:jl]"}
{"concept_id": "C3548894", "aliases": ["negative regulation of ASIC channel in other organism", "negative regulation of acid-sensing ion channel in other organism"], "types": ["T038"], "canonical_name": "negative regulation of acid-sensing ion channel in another organism", "definition": "Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism. [GOC:jl]"}
{"concept_id": "C3548895", "aliases": ["regulation of ASIC channel in other organism", "modulation of acid-sensing ion channel in other organism", "regulation of acid-sensing ion channel in other organism"], "types": ["T038"], "canonical_name": "modulation of acid-sensing ion channel in another organism", "definition": "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an acid-sensing ion channel (ASIC) in another organism. [GOC:jl]"}
{"concept_id": "C3548896", "aliases": ["envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism", "envenomation resulting in negative regulation of ASIC channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of acid-sensing ion channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism. [GOC:fj, GOC:jl, PMID:23034652]"}
{"concept_id": "C3548897", "aliases": ["envenomation resulting in positive regulation of ASIC channel activity in other organism", "envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of acid-sensing ion channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism. [GOC:fj, GOC:jl, PMID:23034652]"}
{"concept_id": "C3548898", "aliases": ["envenomation resulting in modulation of ASIC channel activity in other organism", "envenomation resulting in modulation of acid-sensing ion channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of acid-sensing ion channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an acid-sensing ion channel (ASIC) in the bitten organism. [GOC:fj, GOC:jl, PMID:23034652]"}
{"concept_id": "C3548899", "aliases": [], "types": ["T026"], "canonical_name": "mitotic spindle pole body", "definition": "The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome. [GOC:mah, GOC:vw]"}
{"concept_id": "C3548900", "aliases": ["bone sialoprotein II binding"], "types": ["T044"], "canonical_name": "bone sialoprotein binding", "definition": "Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin. [PMID:10642520]"}
{"concept_id": "C3548901", "aliases": ["double-stranded hemi-methylated DNA binding"], "types": ["T045"], "canonical_name": "hemi-methylated DNA-binding", "definition": "Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. [GOC:imk, GOC:sp, PMID:18772889]"}
{"concept_id": "C3548902", "aliases": [], "types": ["T045"], "canonical_name": "DNA methylation or demethylation", "definition": "The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. [GOC:jl]"}
{"concept_id": "C3548903", "aliases": [], "types": ["T045"], "canonical_name": "DNA demethylation of male pronucleus", "definition": "The active DNA demethylation of the paternal genome that takes place before the first cell division. [GOC:sp, PMID:22868271]"}
{"concept_id": "C3548904", "aliases": [], "types": ["T045"], "canonical_name": "protection of DNA demethylation of female pronucleus", "definition": "The protection of the maternal genome from DNA demethylation in the zygote following fertilization. [GOC:sp, PMID:22868271]"}
{"concept_id": "C3548905", "aliases": [], "types": ["T045"], "canonical_name": "chromatin reprogramming in the zygote", "definition": "The global reprogramming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process. [GOC:sp, PMID:22868271]"}
{"concept_id": "C3548907", "aliases": ["renal phosphate ion excretion"], "types": ["T039"], "canonical_name": "renal phosphate excretion", "definition": "The elimination of phosphate ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. [GOC:jl, PMID:25287933]"}
{"concept_id": "C3548908", "aliases": [], "types": ["T044"], "canonical_name": "protein import into peroxisome matrix, substrate release", "definition": "The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane. [PMID:21976670]"}
{"concept_id": "C3548909", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of imaginal disc-derived wing size", "definition": "Any process that reduces the size of an imaginal disc-derived wing. [PMID:21393605]"}
{"concept_id": "C3548910", "aliases": [], "types": ["T038"], "canonical_name": "regulation of imaginal disc-derived wing size", "definition": "Any process that modulates the size of an imaginal disc-derived wing. [PMID:21393605]"}
{"concept_id": "C3548911", "aliases": ["siderophore membrane transport"], "types": ["T044"], "canonical_name": "siderophore transmembrane transport", "definition": "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore. [GOC:jl]"}
{"concept_id": "C3548912", "aliases": [], "types": ["T044"], "canonical_name": "8-hydroxy-dADP phosphatase activity", "definition": "Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate. [GOC:pde, PMID:22556419]"}
{"concept_id": "C3548913", "aliases": [], "types": ["T044"], "canonical_name": "8-oxo-GDP phosphatase activity", "definition": "Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate. [GOC:pde, PMID:22556419, RHEA:62356]"}
{"concept_id": "C3548914", "aliases": [], "types": ["T044"], "canonical_name": "8-oxo-dGDP phosphatase activity", "definition": "Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate. [GOC:pde, PMID:22556419, RHEA:32063]"}
{"concept_id": "C3548919", "aliases": [], "types": ["T040"], "canonical_name": "single-organism metabolic process"}
{"concept_id": "C3548920", "aliases": [], "types": ["T040"], "canonical_name": "single-organism behavior"}
{"concept_id": "C3548922", "aliases": [], "types": ["T038"], "canonical_name": "multi-multicellular organism process", "definition": "A multicellular organism process which involves another multicellular organism of the same or different species. [GOC:jl]"}
{"concept_id": "C3548925", "aliases": [], "types": ["T039"], "canonical_name": "multi-organism reproductive process", "definition": "A biological process that directly contributes to the process of producing new individuals, involving another organism. [GOC:jl]"}
{"concept_id": "C3548928", "aliases": ["single-organism process"], "types": ["T038"], "canonical_name": "single organism process"}
{"concept_id": "C3548930", "aliases": ["killing by virus of host cell by toxin-antitoxin system", "killing by virus of host cell by PSK"], "types": ["T043"], "canonical_name": "killing by virus of host cell by post-segregational killing", "definition": "The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes. [GOC:bf, GOC:jl, PMID:11222604, Wikipedia:Toxin-antitoxin_system]"}
{"concept_id": "C3548931", "aliases": ["viral entry via genome injection", "viral genome translocation", "pore-mediated penetration of viral genome into host cell"], "types": ["T043"], "canonical_name": "pore-mediated entry of viral genome into host cell", "definition": "Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail. [GOC:jl, UniProtKB-KW:KW-1172, VZ:979]"}
{"concept_id": "C3548932", "aliases": ["trehalose:hydrogen symporter activity"], "types": ["T044"], "canonical_name": "trehalose:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in). [PMID:11136464]"}
{"concept_id": "C3548933", "aliases": [], "types": ["T044"], "canonical_name": "exoribonuclease activator activity", "definition": "Binds to and increases the activity of an exoribonuclease. [GOC:rb, PMID:22570495]"}
{"concept_id": "C3548935", "aliases": ["FO synthase"], "types": ["T044"], "canonical_name": "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity", "definition": "Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + 4-hydroxyphenylpyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 5'-deoxyadenosine + 2 L-methionine + oxalate + ammonia + 4 H+. [GOC:mengo_curators, PMID:11948155, PMID:14593448]"}
{"concept_id": "C3548936", "aliases": [], "types": ["T044"], "canonical_name": "7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity", "definition": "Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+. [GOC:mengo_curators, PMID:19746965]"}
{"concept_id": "C3548937", "aliases": [], "types": ["T044"], "canonical_name": "geranylfarnesyl diphosphate synthase activity", "definition": "Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate. [GOC:mengo_curators, PMID:20097171]"}
{"concept_id": "C3548938", "aliases": [], "types": ["T044"], "canonical_name": "cysteate synthase activity", "definition": "Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-. [GOC:mengo_curators, PMID:19761441]"}
{"concept_id": "C3548939", "aliases": [], "types": ["T044"], "canonical_name": "tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity", "definition": "Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O. [GOC:mengo_curators, PMID:12902326]"}
{"concept_id": "C3548940", "aliases": [], "types": ["T044"], "canonical_name": "dihydromethanopterin reductase activity", "definition": "Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP. [GOC:mengo_curators, PMID:15028691]"}
{"concept_id": "C3548941", "aliases": ["methylthiol:coenzyme M methyl transferase activity"], "types": ["T044"], "canonical_name": "methylthiol:coenzyme M methyltransferase activity", "definition": "Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM. [MetaCyc:RXN-8125, PMID:9371433]"}
{"concept_id": "C3548942", "aliases": ["Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity"], "types": ["T044"], "canonical_name": "archaeal-specific GTP cyclohydrolase activity", "definition": "Catalysis of the reaction: GTP + H2O <=> 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+. [GOC:mengo_curators, PMID:17497938]"}
{"concept_id": "C3548943", "aliases": [], "types": ["T038"], "canonical_name": "sorocarp spore cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass). [GOC:jl, GOC:rjd]"}
{"concept_id": "C3548945", "aliases": [], "types": ["T044"], "canonical_name": "sodium:galactoside symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in). [GOC:crds]"}
{"concept_id": "C3548946", "aliases": [], "types": ["T044"], "canonical_name": "sodium:malonate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in). [GOC:crds]"}
{"concept_id": "C3548947", "aliases": ["L-carnitine:4-(trimethylammonio)butanoate antiporter activity", "L-carnitine:gamma-butyrobetaine antiporter activity", "(R)-carnitine:gamma-butyrobetaine antiporter activity"], "types": ["T043"], "canonical_name": "(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out). [GOC:crds]"}
{"concept_id": "C3548949", "aliases": [], "types": ["T043"], "canonical_name": "establishment or maintenance of cell type involved in phenotypic switching", "definition": "A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. [GOC:jl]"}
{"concept_id": "C3548950", "aliases": ["disruption by organism of host cell membrane"], "types": ["T040"], "canonical_name": "disruption by virus of host cell membrane", "definition": "A process by which a virus has a negative effect on the functioning of a host cellular membrane. [GOC:jl]"}
{"concept_id": "C3548951", "aliases": [], "types": ["T038"], "canonical_name": "disruption by virus of host cell"}
{"concept_id": "C3548952", "aliases": [], "types": ["T043"], "canonical_name": "cytolysis by virus via pore formation in host cell membrane"}
{"concept_id": "C3548953", "aliases": ["lytic viral release", "viral release by host cell lysis", "viral release by cell lysis", "viral exit from host cell by cytolysis", "cytolysis by virus of host cell"], "types": ["T043"], "canonical_name": "viral release from host cell by cytolysis", "definition": "The killing by a virus of a cell by means of the rupture of cell membranes and the loss of cytoplasm. [GOC:jl, PMID:26728778]"}
{"concept_id": "C3548954", "aliases": [], "types": ["T043"], "canonical_name": "pore formation in membrane of host by symbiont", "definition": "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of a host organism. [GOC:jl]"}
{"concept_id": "C3548956", "aliases": ["regulation of post-lysosome size", "regulation of postlysosome vacuole size", "regulation of postlysosomal vacuole size"], "types": ["T039"], "canonical_name": "regulation of post-lysosomal vacuole size", "definition": "Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis. [GOC:rjd, PMID:22008230]"}
{"concept_id": "C3548957", "aliases": ["phagosome pH elevation", "phagosomal reneutralization"], "types": ["T043"], "canonical_name": "phagosome reneutralization", "definition": "Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation. [GOC:rjd, PMID:22008230]"}
{"concept_id": "C3548958", "aliases": [], "types": ["T044"], "canonical_name": "starch alpha-glucosidase activity", "definition": "Catalysis of the reaction: starch + H2O = alpha-D-glucose. [PMID:18556189]"}
{"concept_id": "C3548959", "aliases": [], "types": ["T044"], "canonical_name": "dextrin alpha-glucosidase activity", "definition": "Catalysis of the reaction: dextrin + H2O = alpha-D-glucose. [PMID:18556189]"}
{"concept_id": "C3548960", "aliases": [], "types": ["T040"], "canonical_name": "adhesion of symbiont to host endothelial cell", "definition": "The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly. [GOC:jl, PMID:10066176]"}
{"concept_id": "C3548961", "aliases": [], "types": ["T040"], "canonical_name": "adhesion of symbiont to host epithelial cell", "definition": "The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly. [GOC:jl, PMID:10066176]"}
{"concept_id": "C3548962", "aliases": [], "types": ["T040"], "canonical_name": "adhesion of symbiont to host cell", "definition": "The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly. [GOC:jl]"}
{"concept_id": "C3548963", "aliases": ["envenomation resulting in cytolysis in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in cytolysis in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with cytolysis in the bitten organism. [GOC:fj, GOC:jl, PMID:22484288]"}
{"concept_id": "C3548964", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K4 dimethylation", "definition": "The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone. [GOC:jl, PMID:21875999]"}
{"concept_id": "C3548965", "aliases": ["host-parasite tight junction", "host-pathogen tight junction"], "types": ["T030"], "canonical_name": "host-symbiont bicellular tight junction", "definition": "An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane. [GOC:jl, PMID:21803641]"}
{"concept_id": "C3548966", "aliases": ["envenomation resulting in regulation of complement activation in other organism", "envenomation resulting in modulation of complement activation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of complement activation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation in the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548967", "aliases": ["regulation of complement activation in other organism", "modulation of complement activation in other organism"], "types": ["T038"], "canonical_name": "modulation of complement activation in another organism", "definition": "A process that modulates the frequency, rate or extent of complement activation in a different organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548968", "aliases": ["envenomation resulting in negative regulation of complement activation, alternative pathway in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of complement activation, alternative pathway in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the alternative pathway in the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548969", "aliases": ["envenomation resulting in positive regulation of complement activation, alternative pathway in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of complement activation, alternative pathway in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548970", "aliases": ["envenomation resulting in modulation of complement activation, alternative pathway in other organism", "envenomation resulting in regulation of complement activation, alternative pathway in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of complement activation, alternative pathway in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the alternative pathway in the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548971", "aliases": ["envenomation resulting in positive regulation of complement activation, lectin pathway in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of complement activation, lectin pathway in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the lectin pathway in the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548972", "aliases": ["envenomation resulting in negative regulation of complement activation, lectin pathway in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of complement activation, lectin pathway in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the lectin pathway in the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548973", "aliases": ["envenomation resulting in regulation of complement activation, lectin pathway in other organism", "envenomation resulting in modulation of complement activation, lectin pathway in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of complement activation, lectin pathway in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548974", "aliases": ["envenomation resulting in positive regulation of complement activation, classical pathway in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of complement activation, classical pathway in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548975", "aliases": ["envenomation resulting in negative regulation of complement activation, classical pathway in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of complement activation, classical pathway in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of complement activation via the classical pathway of the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548976", "aliases": ["envenomation resulting in modulation of complement activation, classical pathway in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of complement activation, classical pathway in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism. [GOC:fj, GOC:jl, PMID:20837040]"}
{"concept_id": "C3548977", "aliases": ["positive regulation of complement activation, alternative pathway in other organism"], "types": ["T038"], "canonical_name": "positive regulation of complement activation, alternative pathway in another organism", "definition": "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway, in a different organism. [GOC:jl, PMID:20837040]"}
{"concept_id": "C3548978", "aliases": ["negative regulation of complement activation, alternative pathway in other organism"], "types": ["T038"], "canonical_name": "negative regulation of complement activation, alternative pathway in another organism", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism. [GOC:jl, PMID:20837040]"}
{"concept_id": "C3548979", "aliases": ["modulation of complement activation, alternative pathway in other organism"], "types": ["T038"], "canonical_name": "modulation of complement activation, alternative pathway in another organism", "definition": "A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism. [GOC:jl, PMID:20837040]"}
{"concept_id": "C3548980", "aliases": ["negative regulation of complement activation, lectin pathway in other organism"], "types": ["T038"], "canonical_name": "negative regulation of complement activation, lectin pathway in another organism", "definition": "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism. [GOC:jl, PMID:20837040]"}
{"concept_id": "C3548981", "aliases": ["positive regulation of complement activation, lectin pathway in other organism"], "types": ["T038"], "canonical_name": "positive regulation of complement activation, lectin pathway in another organism", "definition": "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway, in a different organism. [GOC:jl, PMID:20837040]"}
{"concept_id": "C3548982", "aliases": ["modulation of complement activation, lectin pathway in other organism", "regulation of complement activation, lectin pathway in other organism"], "types": ["T038"], "canonical_name": "modulation of complement activation, lectin pathway in another organism", "definition": "A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism. [GOC:jl, PMID:20837040]"}
{"concept_id": "C3548983", "aliases": ["negative regulation of complement activation, classical pathway in other organism"], "types": ["T038"], "canonical_name": "negative regulation of complement activation, classical pathway in another organism", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism. [GOC:jl, PMID:20837040]"}
{"concept_id": "C3548984", "aliases": ["positive regulation of complement activation, classical pathway in other organism"], "types": ["T038"], "canonical_name": "positive regulation of complement activation, classical pathway in another organism", "definition": "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway, in a different organism. [GOC:jl, PMID:20837040]"}
{"concept_id": "C3548985", "aliases": ["modulation of complement activation, classical pathway in other organism", "regulation of complement activation, classical pathway in other organism"], "types": ["T038"], "canonical_name": "modulation of complement activation, classical pathway in another organism", "definition": "A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism. [GOC:jl, PMID:20837040]"}
{"concept_id": "C3548986", "aliases": ["envenomation resulting in positive regulation of cell migration in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of cell migration in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of cell migration in the bitten organism. [GOC:jl, PMID:19932752]"}
{"concept_id": "C3548987", "aliases": ["envenomation resulting in negative regulation of cell migration in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of cell migration in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of cell migration in the bitten organism. [GOC:jl, PMID:19932752]"}
{"concept_id": "C3548988", "aliases": ["envenomation resulting in modulation of cell migration in other organism", "envenomation resulting in regulation of cell migration in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of cell migration in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of cell migration in the bitten organism. [GOC:jl, PMID:19932752]"}
{"concept_id": "C3548989", "aliases": ["positive regulation of cell migration in other organism"], "types": ["T038"], "canonical_name": "positive regulation of cell migration in another organism", "definition": "Any process that activates or increases the frequency, rate or extent of cell migration in a second organism. [GOC:jl]"}
{"concept_id": "C3548990", "aliases": ["negative regulation of cell migration in other organism"], "types": ["T038"], "canonical_name": "negative regulation of cell migration in another organism", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism. [GOC:jl]"}
{"concept_id": "C3548991", "aliases": ["modulation of cell migration in other organism", "regulation of cell migration in other organism"], "types": ["T038"], "canonical_name": "modulation of cell migration in another organism", "definition": "The process in which an organism effects a change in the process of cell migration in a second organism. [GOC:jl]"}
{"concept_id": "C3548992", "aliases": [], "types": ["T044"], "canonical_name": "ACP phosphopantetheine attachment site binding", "definition": "Binding to the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP). [GOC:jl, GOC:vw]"}
{"concept_id": "C3548993", "aliases": ["positive regulation of relaxation of uterine smooth muscle in other organism"], "types": ["T038"], "canonical_name": "positive regulation of relaxation of uterine smooth muscle in another organism", "definition": "The process in which an organism increases the extent of relaxation of smooth muscle in the uterus of a second organism. [GOC:jl]"}
{"concept_id": "C3548994", "aliases": ["modulation of relaxation of uterine smooth muscle in other organism", "regulation of relaxation of uterine smooth muscle in other organism"], "types": ["T038"], "canonical_name": "modulation of relaxation of uterine smooth muscle in another organism", "definition": "The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism. [GOC:jl]"}
{"concept_id": "C3548995", "aliases": ["modulation of relaxation of smooth muscle in other organism", "regulation of relaxation of smooth muscle in other organism"], "types": ["T038"], "canonical_name": "modulation of relaxation of smooth muscle in another organism", "definition": "The process in which an organism effects a change in the relaxation of smooth muscle in a second organism. [GOC:jl]"}
{"concept_id": "C3548996", "aliases": ["regulation of relaxation of muscle in other organism", "modulation of relaxation of muscle in other organism"], "types": ["T038"], "canonical_name": "modulation of relaxation of muscle in another organism", "definition": "The process in which an organism effects a change in the relaxation of muscle in a second organism. [GOC:jl]"}
{"concept_id": "C3548997", "aliases": [], "types": ["T026"], "canonical_name": "nuclear pore nuclear basket", "definition": "A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component. [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]"}
{"concept_id": "C3548998", "aliases": ["cytoplasmic fibers of the nuclear pore complex", "cytoplasmic fibers of the NPC", "cytoplasmic fibers of the nuclear pore complex location"], "types": ["T026"], "canonical_name": "nuclear pore cytoplasmic filaments", "definition": "Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component. [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]"}
{"concept_id": "C3548999", "aliases": ["nuclear pore central plug", "nuclear pore transport channel", "nuclear pore central channel"], "types": ["T026"], "canonical_name": "nuclear pore central transport channel", "definition": "The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153. [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]"}
{"concept_id": "C3549000", "aliases": [], "types": ["T026"], "canonical_name": "nuclear pore linkers", "definition": "A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p). [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]"}
{"concept_id": "C3549001", "aliases": ["flavine mononucleotide transmembrane transporter activity"], "types": ["T044"], "canonical_name": "FMN transmembrane transporter activity", "definition": "Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other. [GOC:ans, PMID:22185573]"}
{"concept_id": "C3549002", "aliases": ["peptidyl-threonine esterification"], "types": ["T044"], "canonical_name": "peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine", "definition": "The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester. [RESID:AA0507]"}
{"concept_id": "C3549004", "aliases": [], "types": ["T044"], "canonical_name": "phosphocholine hydrolase activity", "definition": "Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate. [GOC:sp, PMID:22158903]"}
{"concept_id": "C3549005", "aliases": [], "types": ["T044"], "canonical_name": "phosphocholine transferase activity", "definition": "Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate. [GOC:sp, PMID:21822290]"}
{"concept_id": "C3549006", "aliases": ["ATP-dependent phytochelatin transmembrane transporter activity", "phytochelatin transmembrane transporter ATPase activity"], "types": ["T044"], "canonical_name": "ATPase-coupled phytochelatin transmembrane transporter activity"}
{"concept_id": "C3549007", "aliases": ["protein deAMPylase activity", "protein deAMPylation activity"], "types": ["T044"], "canonical_name": "protein adenylylhydrolase activity", "definition": "Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins. [PMID:21734656]"}
{"concept_id": "C3549008", "aliases": ["protein deAMPylation"], "types": ["T044"], "canonical_name": "protein deadenylylation", "definition": "The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid. [GOC:sp, PMID:21734656]"}
{"concept_id": "C3549009", "aliases": [], "types": ["T044"], "canonical_name": "protein denucleotidylation", "definition": "The removal of a nucleotide from a protein amino acid. [GOC:sp, PMID:21734656]"}
{"concept_id": "C3549010", "aliases": [], "types": ["T044"], "canonical_name": "protein guanylyltransferase activity", "definition": "Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins. [GOC:sp, PMID:20651120]"}
{"concept_id": "C3549011", "aliases": [], "types": ["T044"], "canonical_name": "doxorubicin metabolic process", "definition": "The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy. [PMID:10200167]"}
{"concept_id": "C3549012", "aliases": [], "types": ["T044"], "canonical_name": "daunorubicin metabolic process", "definition": "The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. [PMID:20837989]"}
{"concept_id": "C3549013", "aliases": [], "types": ["T044"], "canonical_name": "3-demethylubiquinol-10 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-10 = S-adenosyl-L-homocysteine + ubiquinol-10. [PMID:10777520]"}
{"concept_id": "C3549014", "aliases": [], "types": ["T044"], "canonical_name": "decaprenyldihydroxybenzoate methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate. [PMID:10777520]"}
{"concept_id": "C3549015", "aliases": [], "types": ["T044"], "canonical_name": "17-beta-hydroxysteroid dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+. [PMID:17074428]"}
{"concept_id": "C3549016", "aliases": ["iron molybdenum cofactor assembly", "FeMoco biosynthetic process", "iron molybdenum cofactor biosynthetic process", "FeMoco assembly", "iron molybdenum cofactor biosynthesis"], "types": ["T044"], "canonical_name": "iron-sulfur-molybdenum cofactor assembly", "definition": "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase. [GOC:mengo_curators, GOC:tt, PMID:18429691]"}
{"concept_id": "C3549017", "aliases": [], "types": ["T043"], "canonical_name": "response to pullulan", "definition": "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of pullulan stimulus. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549018", "aliases": [], "types": ["T043"], "canonical_name": "response to amylopectin", "definition": "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of amylopectin stimulus. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549019", "aliases": ["FeMo co binding", "FeMoco binding"], "types": ["T044"], "canonical_name": "iron-sulfur-molybdenum cofactor binding", "definition": "Binding to iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase. [GOC:mengo_curators, GOC:tt, PMID:18429691]"}
{"concept_id": "C3549020", "aliases": [], "types": ["T044"], "canonical_name": "pectin binding", "definition": "Binding to pectin. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549021", "aliases": [], "types": ["T044"], "canonical_name": "laminaribiose binding", "definition": "Binding to laminaribiose, a disaccharide. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549022", "aliases": [], "types": ["T044"], "canonical_name": "cellopentaose binding", "definition": "Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549023", "aliases": [], "types": ["T044"], "canonical_name": "cellotetraose binding", "definition": "Binding to a cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549024", "aliases": [], "types": ["T044"], "canonical_name": "cellobiose binding", "definition": "Binding to cellobiose, a disaccharide that represents the basic repeating unit of cellulose. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549025", "aliases": [], "types": ["T044"], "canonical_name": "cellodextrin binding", "definition": "Binding to a cellodextrin, a glucose polymer of 2 or more glucose monomers. [GOC:mengo_curators, GOC:tt, PMID:18952792]"}
{"concept_id": "C3549026", "aliases": [], "types": ["T044"], "canonical_name": "cellotriose binding", "definition": "Binding to cellotriose. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549027", "aliases": ["butyryl-CoA catabolism to butanol"], "types": ["T044"], "canonical_name": "butyryl-CoA catabolic process to butanol", "definition": "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butanol. [GOC:mengo_curators, GOC:tt, PMID:19539744]"}
{"concept_id": "C3549028", "aliases": ["butyryl-CoA catabolism to butyrate"], "types": ["T044"], "canonical_name": "butyryl-CoA catabolic process to butyrate", "definition": "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate. [GOC:mengo_curators, GOC:tt, PMID:19539744]"}
{"concept_id": "C3549029", "aliases": ["butyryl-CoA catabolism"], "types": ["T044"], "canonical_name": "butyryl-CoA catabolic process", "definition": "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA. [GOC:jl]"}
{"concept_id": "C3549030", "aliases": ["butyryl-CoA biosynthesis from acetyl-CoA"], "types": ["T044"], "canonical_name": "butyryl-CoA biosynthetic process from acetyl-CoA", "definition": "The chemical reactions and pathway resulting in the formation of butyryl-CoA, starting from acetyl-CoA. [GOC:mengo_curators, GOC:tt, PMID:19539744]"}
{"concept_id": "C3549031", "aliases": ["butyryl-CoA biosynthesis"], "types": ["T044"], "canonical_name": "butyryl-CoA biosynthetic process", "definition": "The chemical reactions and pathway resulting in the formation of butyryl-CoA. [GOC:jl]"}
{"concept_id": "C3549032", "aliases": ["xylose catabolism to ethanol"], "types": ["T044"], "canonical_name": "xylose catabolic process to ethanol", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of xylose, an aldopentose, where one of the resulting products is ethanol. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549033", "aliases": ["pentose catabolism to ethanol"], "types": ["T044"], "canonical_name": "pentose catabolic process to ethanol", "definition": "The anaerobic chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbons, where one of the resulting products is ethanol. [GOC:mengo_curators, GOC:tt]"}
{"concept_id": "C3549034", "aliases": [], "types": ["T043"], "canonical_name": "cellulosome assembly", "definition": "The assembly of a cellulosome, a macromolecular multi-enzyme complex in bacteria that facilitates the breakdown of cellulase, hemicellulase and pectin in the plant cell wall. [GOC:mengo_curators, GOC:tt, PMID:20373916]"}
{"concept_id": "C3549035", "aliases": ["assembly of starch utilization system complex", "SUS complex assembly"], "types": ["T044"], "canonical_name": "starch utilization system complex assembly", "definition": "The aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan. [GOC:mengo_curators, GOC:tt, PMID:19553672, PMID:21219452]"}
{"concept_id": "C3549036", "aliases": ["nitrogenase P cluster maturation", "nitrogenase P cluster biosynthesis"], "types": ["T044"], "canonical_name": "nitrogenase P cluster assembly", "definition": "The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two [4Fe-4S] sub-clusters sharing a gamma-6-sulfide. [PMID:17563349]"}
{"concept_id": "C3549037", "aliases": [], "types": ["T043"], "canonical_name": "chondrocyte activation", "definition": "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage. [CL:0000138, GOC:jl]"}
{"concept_id": "C3549038", "aliases": [], "types": ["T043"], "canonical_name": "dendritic cell proliferation", "definition": "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. [CL:0000451, PMID:18469816]"}
{"concept_id": "C3549039", "aliases": ["envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in occlusion of the pore of voltage-gated potassium channel in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore's activity, in the bitten/stung organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3549040", "aliases": ["envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism", "voltage-dependence of activation shift (to the left)"], "types": ["T038"], "canonical_name": "envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3549041", "aliases": ["envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3549042", "aliases": ["modulation of ion channel activity in other organism", "regulation of ion channel activity in other organism"], "types": ["T038"], "canonical_name": "modulation of ion channel activity in another organism", "definition": "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an ion channel in another organism. [GOC:jl]"}
{"concept_id": "C3549043", "aliases": ["envenomation resulting in regulation of ion channel activity in other organism", "envenomation resulting in modulation of ion channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of ion channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an ion channel in the bitten organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3549044", "aliases": ["envenomation resulting in modulation of voltage-gated potassium channel activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in modulation of voltage-gated potassium channel activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism. [GOC:fj, GOC:jl]"}
{"concept_id": "C3549045", "aliases": ["regulation of vasodilation in other organism"], "types": ["T038"], "canonical_name": "modulation of vasodilation in other organism"}
{"concept_id": "C3549046", "aliases": ["cell wall disruption in other organism"], "types": ["T038"], "canonical_name": "cell wall disruption in another organism", "definition": "A process carried out by an organism that results in the breakdown of the cell wall of a second organism. [GOC:jl]"}
{"concept_id": "C3549047", "aliases": ["structural maintenance of chromosomes family protein binding"], "types": ["T044"], "canonical_name": "SMC family protein binding", "definition": "Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization. [GOC:jl, GOC:vw, InterPro:IPR024704, PMID:9640531]"}
{"concept_id": "C3549048", "aliases": ["extracellular fibril organization"], "types": ["T043"], "canonical_name": "extracellular fibril organisation"}
{"concept_id": "C3549049", "aliases": [], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis]"}
{"concept_id": "C3549050", "aliases": ["activation of host NF-kappa-B by virus", "activation by virus of host NF-kappaB transcription factor activity"], "types": ["T043"], "canonical_name": "induction by virus of host NF-kappaB cascade", "definition": "Any process in which a virus starts, promotes, or enhances a host NF-kappaB cascade. [PMID:11907233, PMID:7845680]"}
{"concept_id": "C3549051", "aliases": [], "types": ["T043"], "canonical_name": "induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process", "definition": "Any process in which a virus increases the frequency, rate or extent of host cysteine-type endopeptidase activity (also called caspase activity) which contributes to the apoptotic process. [GOC:mtg_apoptosis, UniProtKB-KW:KW-1073]"}
{"concept_id": "C3549052", "aliases": [], "types": ["T043"], "canonical_name": "suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host caspase activity. Caspases are cysteine-type endopeptidases which contribute to the apoptotic process. [UniProtKB-KW:KW-1085, VZ:912]"}
{"concept_id": "C3549053", "aliases": [], "types": ["T044"], "canonical_name": "modulation by virus of host ubiquitin-protein ligase activity", "definition": "The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. [UniProtKB-KW:KW-1123]"}
{"concept_id": "C3549054", "aliases": [], "types": ["T038"], "canonical_name": "modulation by virus of host protein ubiquitination", "definition": "Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein. [UniProtKB-KW:KW-1130]"}
{"concept_id": "C3549056", "aliases": ["G0/G1 host cell cycle checkpoint dysregulation by virus"], "types": ["T043"], "canonical_name": "modulation by virus of host G0/G1 transition checkpoint", "definition": "Any viral process that modulates the frequency, rate or extent of the host cell G0/G1 transition checkpoint. [UniProtKB-KW:KW-1077]"}
{"concept_id": "C3549057", "aliases": ["G1/S host cell cycle checkpoint dysregulation by virus"], "types": ["T043"], "canonical_name": "modulation by virus of host G1/S transition checkpoint", "definition": "Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint. [UniProtKB-KW:KW-1078]"}
{"concept_id": "C3549058", "aliases": ["suppression by virus of host NF-kappaB transcription factor activity", "inhibition of host NF-kappa-B by virus"], "types": ["T044"], "canonical_name": "suppression by virus of host NF-kappaB cascade", "definition": "Any process in which a virus stops, prevents, or reduces a host NF-kappaB cascade. [PMID:10920188, PMID:25275128]"}
{"concept_id": "C3549059", "aliases": [], "types": ["T026"], "canonical_name": "host cell viral nucleoid", "definition": "The region of a host cell that contains the viral genome. [GOC:bf, GOC:bm, GOC:jl]"}
{"concept_id": "C3549060", "aliases": [], "types": ["T026"], "canonical_name": "virion nucleoid", "definition": "The region of a virion in which the nucleic acid is confined. [GOC:bm, PMID:14291596]"}
{"concept_id": "C3549061", "aliases": ["virion inner membrane"], "types": ["T026"], "canonical_name": "viral inner membrane", "definition": "The lipid bilayer of a virion contained inside the protein capsid. [GOC:bm, PMID:15331712]"}
{"concept_id": "C3549062", "aliases": [], "types": ["T043"], "canonical_name": "cytolysis by virus via suppression of host peptidoglycan biosynthetic process"}
{"concept_id": "C3549063", "aliases": ["suppression by virus of host cell lysis in response to superinfecting virus"], "types": ["T040"], "canonical_name": "suppression by virus of host cell lysis in response to superinfection", "definition": "The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus. [GOC:bm, GOC:jl, PMID:22389108, PMID:9560373]"}
{"concept_id": "C3549064", "aliases": ["LPS binding involved in viral attachment to host cell", "virion attachment, binding to host lipopolysaccharide", "lipopolysaccharide binding involved in viral attachment to host cell"], "types": ["T044"], "canonical_name": "lipopolysaccharide-mediated virion attachment to host cell", "definition": "The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface. [GOC:bf, GOC:bm, PMID:12837775]"}
{"concept_id": "C3549065", "aliases": [], "types": ["T040"], "canonical_name": "catabolism by virus of host DNA", "definition": "The breakdown of host DNA, deoxyribonucleic acid, by a virus. [GOC:bf, GOC:bm, GOC:jl]"}
{"concept_id": "C3549066", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host cell wall biogenesis", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts. [GOC:bf, GOC:bm, GOC:jl]"}
{"concept_id": "C3549067", "aliases": ["killing by virus of host cells involved in superinfection exclusion", "killing by virus of host cells during superinfection exclusion"], "types": ["T040"], "canonical_name": "killing by virus of host cell during superinfection exclusion", "definition": "The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus. [GOC:bf, GOC:bm, GOC:jl, PMID:22398285]"}
{"concept_id": "C3549068", "aliases": ["killing by virus of host cells"], "types": ["T040"], "canonical_name": "killing by virus of host cell", "definition": "Any process mediated by a virus that results in the death of a cell in the host organism. [GOC:bf, GOC:bm, GOC:jl]"}
{"concept_id": "C3549069", "aliases": ["RNA packaging ATPase activity"], "types": ["T045"], "canonical_name": "RNA translocase activity involved in viral RNA genome packaging", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule, which contributes to the packaging of viral RNA into a nucleocapsid. [GOC:bm, PMID:22297533]"}
{"concept_id": "C3549070", "aliases": [], "types": ["T045"], "canonical_name": "DNA translocase activity involved in viral DNA genome packaging", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid. [GOC:bm, PMID:17501915]"}
{"concept_id": "C3549071", "aliases": [], "types": ["T045"], "canonical_name": "RNA translocase activity", "definition": "Generating a movement along a single- or double-stranded RNA molecule, driven by ATP hydrolysis. [GOC:bm, PMID:22713318]"}
{"concept_id": "C3549072", "aliases": [], "types": ["T026"], "canonical_name": "T=219 icosahedral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins. [GOC:plm, UniProtKB-KW:KW-1151]"}
{"concept_id": "C3549073", "aliases": ["T=169 icosahedral capsid"], "types": ["T026"], "canonical_name": "T=169 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins. [GOC:plm, UniProtKB-KW:KW-1150]"}
{"concept_id": "C3549074", "aliases": [], "types": ["T026"], "canonical_name": "T=147 icosahedral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins. [GOC:plm, UniProtKB-KW:KW-0167]"}
{"concept_id": "C3549075", "aliases": ["intermediate capsid"], "types": ["T026"], "canonical_name": "viral intermediate capsid", "definition": "The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions. [UniProtKB-KW:KW-1154]"}
{"concept_id": "C3549076", "aliases": ["inner capsid"], "types": ["T026"], "canonical_name": "viral inner capsid", "definition": "The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions. [UniProtKB-KW:KW-1153]"}
{"concept_id": "C3549077", "aliases": ["outer capsid"], "types": ["T026"], "canonical_name": "viral outer capsid", "definition": "The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions. [UniProtKB-KW:KW-1152]"}
{"concept_id": "C3549078", "aliases": [], "types": ["T026"], "canonical_name": "T=25 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres. [UniProtKB-KW:KW-1148, VZ:810]"}
{"concept_id": "C3549079", "aliases": [], "types": ["T026"], "canonical_name": "T=16 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres. [UniProtKB-KW:KW-1147, VZ:807]"}
{"concept_id": "C3549080", "aliases": [], "types": ["T026"], "canonical_name": "T=13 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres. [UniProtKB-KW:KW-1146, VZ:260]"}
{"concept_id": "C3549081", "aliases": [], "types": ["T026"], "canonical_name": "T=7 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres. [UniProtKB-KW:KW-1145, VZ:804]"}
{"concept_id": "C3549082", "aliases": [], "types": ["T026"], "canonical_name": "T=4 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres. [UniProtKB-KW:KW-1144, VZ:808]"}
{"concept_id": "C3549083", "aliases": [], "types": ["T026"], "canonical_name": "T=pseudo3 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres. [UniProtKB-KW:KW-1143, VZ:809]"}
{"concept_id": "C3549084", "aliases": [], "types": ["T026"], "canonical_name": "T=3 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres. [UniProtKB-KW:KW-1142, VZ:806]"}
{"concept_id": "C3549085", "aliases": [], "types": ["T026"], "canonical_name": "T=2 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers. [UniProtKB-KW:KW-1141, VZ:838]"}
{"concept_id": "C3549086", "aliases": [], "types": ["T026"], "canonical_name": "T=1 icosahedral viral capsid", "definition": "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres. [UniProtKB-KW:KW-1140, VZ:1057]"}
{"concept_id": "C3549087", "aliases": [], "types": ["T043"], "canonical_name": "induction by virus of host protein phosphorylation", "definition": "Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host. [GOC:bf]"}
{"concept_id": "C3549088", "aliases": ["viral inhibition of host protein phosphorylation"], "types": ["T043"], "canonical_name": "suppression by virus of host protein phosphorylation", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host. [GOC:bf]"}
{"concept_id": "C3549089", "aliases": [], "types": ["T038"], "canonical_name": "modulation by virus of host protein phosphorylation", "definition": "Any viral process that modulates the frequency, rate or extent of phosphorylation of viral or host proteins in a host. [GOC:bf]"}
{"concept_id": "C3549092", "aliases": [], "types": ["T045"], "canonical_name": "suppression by virus of host translation initiation", "definition": "Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein. [GOC:bf]"}
{"concept_id": "C3549094", "aliases": ["viral shutoff of host protein synthesis", "host translation shutoff by virus", "viral inhibition of cellular protein synthesis"], "types": ["T045"], "canonical_name": "suppression by virus of host translation", "definition": "Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA, for example by cleavage of the host mRNAs. [PMID:22046136, PMID:22174690]"}
{"concept_id": "C3549096", "aliases": ["suppression by virus of host DNA-dependent transcription, initiation", "inhibition of host transcription initiation by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host transcription initiation from RNA polymerase II promoter", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template. [UniProtKB-KW:KW-1111, VZ:904]"}
{"concept_id": "C3549101", "aliases": [], "types": ["T038"], "canonical_name": "modulation by virus of host protein dephosphorylation", "definition": "Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein. [GOC:bf]"}
{"concept_id": "C3549102", "aliases": ["virus-mediated mRNA decay", "promotion of host mRNA degradation", "induction by virus of host mRNA catabolic process", "viral induction of host mRNA decay", "induction of host mRNA decay"], "types": ["T038"], "canonical_name": "induction by virus of catabolism of host mRNA", "definition": "The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA). [GOC:bf, UniProtKB-KW:KW-1132]"}
{"concept_id": "C3549103", "aliases": [], "types": ["T045"], "canonical_name": "endoribonuclease activity involved in viral induction of host mRNA catabolic process", "definition": "Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA. [GOC:bf, PMID:22046136]"}
{"concept_id": "C3549104", "aliases": ["inhibition of host mitotic exit by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host exit from mitosis", "definition": "Any viral process which decreases the rate or extent of a host cell leaving M phase of the cell cycle. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. [UniProtKB-KW:KW-1098, VZ:877]"}
{"concept_id": "C3549105", "aliases": ["host G2/M cell cycle arrest by virus"], "types": ["T043"], "canonical_name": "suppression by virus of G2/M transition of host mitotic cell cycle", "definition": "Any viral process that decreases the rate or extent of progression from G2 phase to M phase of the host mitotic cell cycle. [UniProtKB-KW:KW-1079, VZ:876]"}
{"concept_id": "C3549108", "aliases": ["inhibition of host proteasome antigen processing by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host antigen processing and presentation", "definition": "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex. [UniProtKB-KW:KW-1117, VZ:815]"}
{"concept_id": "C3549109", "aliases": ["inhibition of host BST2/Tetherin by virus"], "types": ["T044"], "canonical_name": "suppression by virus of host tetherin activity", "definition": "Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects. [PMID:22493439]"}
{"concept_id": "C3549110", "aliases": ["modulation of host PP1 activity by virus", "regulation by virus of host PP1 activity"], "types": ["T044"], "canonical_name": "modulation by virus of host PP1 activity", "definition": "The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response. [UniProtKB-KW:KW-1126, VZ:803]"}
{"concept_id": "C3549111", "aliases": ["PKR signal transduction", "EIF2AK3/PERK signaling", "signaling through PKR", "EIF2AK3 signal transduction", "PKR signaling pathway"], "types": ["T044"], "canonical_name": "PKR-mediated signaling", "definition": "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK3), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation. [PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576]"}
{"concept_id": "C3549112", "aliases": [], "types": ["T044"], "canonical_name": "suppression by virus of host protein kinase activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity. [GOC:bf]"}
{"concept_id": "C3549116", "aliases": ["suppression by virus of host EIF2AK2 activity"], "types": ["T043"], "canonical_name": "suppression by virus of host PKR activity"}
{"concept_id": "C3549117", "aliases": [], "types": ["T043"], "canonical_name": "suppression by virus of host ISG15 activity"}
{"concept_id": "C3549120", "aliases": ["suppression by virus of host JAK1 activity", "suppression by virus of host janus kinase 1 activity", "negative regulation by virus of host JAK", "inhibition of host JAK activity by virus"], "types": ["T040"], "canonical_name": "suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host JAK1 (Janus Kinase 1). [PMID:16188985]"}
{"concept_id": "C3549122", "aliases": ["suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity", "suppression by virus of host TYK2 activity"], "types": ["T043"], "canonical_name": "suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK1-STAT signaling cascade in a host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits. [PMID:16987978, PMID:19085955]"}
{"concept_id": "C3549130", "aliases": ["suppression by virus of host STAT activity", "suppression by virus of host signal transducer and activator of transcription activity"], "types": ["T038"], "canonical_name": "suppression by virus of host JAK-STAT cascade via inhibition of STAT activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes. [GOC:bf]"}
{"concept_id": "C3549132", "aliases": ["suppression by virus of host IRF9 activity", "suppression by virus of host interferon regulatory factor 9 activity", "inhibition of host interferon regulatory factor-9 by virus", "inhibition of host IRF9 by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity", "definition": "Any process in which a virus stops, prevents, or reduces a JAK1-STAT signaling cascade in a host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes. [PMID:10388655, PMID:19109390]"}
{"concept_id": "C3549134", "aliases": ["suppression by virus of host interferon regulatory factor 7 activity", "inhibition of host IRF7 by virus", "inhibition of host interferon regulatory factor-7 by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host IRF7 activity"}
{"concept_id": "C3549135", "aliases": ["MDA5 binding"], "types": ["T044"], "canonical_name": "MDA-5 binding", "definition": "Binding to MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA. [PMID:19019954]"}
{"concept_id": "C3549137", "aliases": ["Inhibition of host MDA5 by virus"], "types": ["T044"], "canonical_name": "suppression by virus of host MDA-5 activity"}
{"concept_id": "C3549138", "aliases": ["complement component C5a-induced signaling pathway"], "types": ["T044"], "canonical_name": "complement component C5a signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by a C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor. [GOC:jc, PMID:15313431, Wikipedia:Complement_component_5a]"}
{"concept_id": "C3549139", "aliases": ["death receptor activator activity"], "types": ["T044"], "canonical_name": "death receptor agonist activity", "definition": "Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor. [GOC:mtg_apoptosis, GOC:pr]"}
{"concept_id": "C3549140", "aliases": ["positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels"], "types": ["T043"], "canonical_name": "positive regulation of SREBP signaling pathway in response to decreased oxygen levels", "definition": "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels. [GOC:al, PMID:22017871]"}
{"concept_id": "C3549141", "aliases": ["negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels"], "types": ["T044"], "canonical_name": "negative regulation of SREBP signaling pathway in response to increased oxygen levels", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels. [GOC:al, PMID:22017871]"}
{"concept_id": "C3549142", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-17A receptor activity", "definition": "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:jc, GOC:signaling]"}
{"concept_id": "C3549143", "aliases": ["interleukin-17A-mediated signalling pathway", "IL-17A-mediated signaling pathway", "IL17A signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-17A-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-17A binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, GOC:signaling]"}
{"concept_id": "C3549144", "aliases": ["interleukin-33-mediated signalling pathway", "IL-33-mediated signaling pathway", "IL33 signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-33-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-33 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, GOC:signaling]"}
{"concept_id": "C3549145", "aliases": ["cannabinoid-mediated signaling pathway", "cannabinoid-activated signaling pathway", "cannabinoid receptor signaling pathway"], "types": ["T044"], "canonical_name": "cannabinoid signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. [GOC:bf, GOC:jc, GOC:signaling, Wikipedia:Cannabinoid]"}
{"concept_id": "C3549146", "aliases": ["somatostatin signalling pathway", "somatostatin-mediated signaling pathway", "somatostatin-activated somatostatin receptor signaling pathway", "SRIF signaling pathway", "SST signaling pathway", "somatotrophin release inhibiting factor signaling pathway"], "types": ["T044"], "canonical_name": "somatostatin signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin]"}
{"concept_id": "C3549147", "aliases": ["EGFR signaling pathway via IKK/NF-kappaB cascade", "EGFR signaling pathway via IKK-dependent activation of NF-kappaB"], "types": ["T044"], "canonical_name": "epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade", "definition": "An epidermal growth factor receptor signaling pathway in which the signal transmitted via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB. [GOC:bf, PMID:22132240]"}
{"concept_id": "C3549148", "aliases": ["EGFR signaling pathway via activation of NF-kappaB", "epidermal growth factor receptor signalling pathway via positive regulation of NF-kappaB transcription factor activity"], "types": ["T044"], "canonical_name": "epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity", "definition": "An epidermal growth factor receptor signaling pathway in which the signal transmitted via the activation of the transcription factor NF-kappaB. [GOC:signaling, GOC:uh, PMID:21229383, PMID:21518868, PMID:22132240]"}
{"concept_id": "C3549149", "aliases": ["OSM signaling pathway", "oncostatin-M signaling pathway"], "types": ["T043"], "canonical_name": "oncostatin-M-mediated signaling pathway", "definition": "The series of molecular signals initiated by oncostatin-M (OSM) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways. [GOC:nhn, GOC:signaling, PMID:10579456, PMID:12811586]"}
{"concept_id": "C3549150", "aliases": [], "types": ["T044"], "canonical_name": "thrombopoietin receptor activity", "definition": "Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:signaling, PMID:19630807]"}
{"concept_id": "C3549151", "aliases": ["thrombopoietin receptor signaling pathway", "THPO/MPL signaling pathway", "THPO signaling pathway"], "types": ["T043"], "canonical_name": "thrombopoietin-mediated signaling pathway", "definition": "The series of molecular signals initiated by thrombopoietin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:19630807]"}
{"concept_id": "C3549152", "aliases": ["erythropoietin receptor signaling pathway", "EPO-R signaling pathway"], "types": ["T043"], "canonical_name": "erythropoietin-mediated signaling pathway", "definition": "The series of molecular signals initiated by erythropoietin (EPO) binding to the erythropoietin receptor (EPO-R) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, PMID:12489509]"}
{"concept_id": "C3549153", "aliases": ["CXCL12-activated CXCR4 signalling pathway"], "types": ["T043"], "canonical_name": "CXCL12-activated CXCR4 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn]"}
{"concept_id": "C3549154", "aliases": ["interleukin-3-mediated signalling pathway", "IL-3-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-3-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3549155", "aliases": ["interleukin-23-mediated signalling pathway", "IL-23-mediated signaling pathway"], "types": ["T043"], "canonical_name": "interleukin-23-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-23 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3549156", "aliases": ["IL-11-mediated signaling pathway", "interleukin-11-mediated signalling pathway"], "types": ["T043"], "canonical_name": "interleukin-11-mediated signaling pathway", "definition": "The series of molecular signals initiated by the binding of interleukin-11 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3549157", "aliases": ["C-C chemokine receptor type 4 signaling pathway", "chemokine receptor CCR4 signaling pathway"], "types": ["T043"], "canonical_name": "C-C chemokine receptor CCR4 signaling pathway", "definition": "The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3549158", "aliases": ["CCL2/CCR2 signaling pathway"], "types": ["T043"], "canonical_name": "CCL2-activated CCR2 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3549159", "aliases": ["C-C chemokine receptor type 2 signaling pathway"], "types": ["T043"], "canonical_name": "C-C chemokine receptor CCR2 signaling pathway", "definition": "The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]"}
{"concept_id": "C3549160", "aliases": ["CCL2 receptor activity"], "types": ["T044"], "canonical_name": "C-C motif chemokine 2 receptor activity", "definition": "Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:signaling]"}
{"concept_id": "C3549161", "aliases": ["CCL2 signaling pathway"], "types": ["T043"], "canonical_name": "chemokine (C-C motif) ligand 2 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, Wikipedia:CCL2]"}
{"concept_id": "C3549162", "aliases": ["SDF1 signaling pathway", "stromal cell-derived factor-1 signaling pathway", "CXCL12 signaling pathway"], "types": ["T043"], "canonical_name": "chemokine (C-X-C motif) ligand 12 signaling pathway", "definition": "The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, Wikipedia:Stromal_cell-derived_factor-1]"}
{"concept_id": "C3549163", "aliases": ["macrophage colony-stimulating factor signalling pathway", "M-CSF signaling pathway"], "types": ["T043"], "canonical_name": "macrophage colony-stimulating factor signaling pathway", "definition": "The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, GOC:uh, PMID:12138890, Wikipedia:Macrophage_colony-stimulating_factor]"}
{"concept_id": "C3549164", "aliases": ["protein localisation to T-tubule", "protein localization to transverse tubule", "protein localization to T tubule"], "types": ["T043"], "canonical_name": "protein localization to T-tubule", "definition": "A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. [GOC:BHF, GOC:rl, PMID:16292983]"}
{"concept_id": "C3549165", "aliases": [], "types": ["T044"], "canonical_name": "D-alanyl carrier activity", "definition": "Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG). [GOC:crds, PMID:11222605, PMID:22750871, PMID:8682792]"}
{"concept_id": "C3549166", "aliases": ["cone response recovery"], "types": ["T044"], "canonical_name": "cone photoresponse recovery", "definition": "The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers. [GOC:gap, PMID:16039565, PMID:22802362]"}
{"concept_id": "C3549167", "aliases": [], "types": ["T043"], "canonical_name": "light adaption", "definition": "The ability of a photoreceptor to adjust to varying levels of light. [GOC:gap, PMID:16039565]"}
{"concept_id": "C3549168", "aliases": ["TGF-beta 3 activation", "TGFbeta 3 activation", "TGFB3 activation"], "types": ["T038"], "canonical_name": "transforming growth factor beta3 activation", "definition": "The release of transforming growth factor beta 3 (TGF-beta3) from its latent state. [GOC:sl, PMID:12482908, PMID:9170210]"}
{"concept_id": "C3549169", "aliases": ["TGF-beta 2 activation", "TGFbeta 2 activation", "TGFB2 activation"], "types": ["T044"], "canonical_name": "transforming growth factor beta2 activation", "definition": "The release of transforming growth factor beta 2 (TGF-beta2) from its latent state. [GOC:sl, PMID:12482908, PMID:9170210]"}
{"concept_id": "C3549170", "aliases": ["TGFbeta 1 activation", "latent-TGF-beta1 activation", "transforming growth factor-beta1 activation", "TGF-beta 1 activation", "TGFB1 activation", "L-TGF-beta 1 activation"], "types": ["T038"], "canonical_name": "transforming growth factor beta1 activation", "definition": "The release of transforming growth factor beta1 (TGF-beta1) from its latent state. [GOC:sl, PMID:12482908, PMID:9170210]"}
{"concept_id": "C3549171", "aliases": ["latent TGF-beta activation", "L-TGF-beta activation", "TGFB activation", "TGF-beta activation", "TGFbeta activation", "TGF-B activation"], "types": ["T044"], "canonical_name": "transforming growth factor beta activation", "definition": "The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms. [GOC:bf, GOC:sl, PMID:12482908, PMID:9170210]"}
{"concept_id": "C3549172", "aliases": [], "types": ["T026"], "canonical_name": "ascus membrane", "definition": "A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi. [GOC:mcc, GOC:vw, PMID:21900489]"}
{"concept_id": "C3549173", "aliases": [], "types": ["T044"], "canonical_name": "racemase activity, acting on amino acids and derivatives", "definition": "Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. [GOC:crds]"}
{"concept_id": "C3549174", "aliases": ["renal K+ elimination", "renal potassium ion excretion", "renal K(+) excretion"], "types": ["T039"], "canonical_name": "renal potassium excretion", "definition": "The elimination of potassium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. [GOC:gap, PMID:15034090, PMID:25287933]"}
{"concept_id": "C3549175", "aliases": ["D-alanyl lipoteichoic acid formation", "D-alanyl LTA formation", "LTA D-alanylation"], "types": ["T044"], "canonical_name": "lipoteichoic acid D-alanylation", "definition": "The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA). [GOC:crds, PMID:22750871, PMID:8682792]"}
{"concept_id": "C3549176", "aliases": ["2PGK activity"], "types": ["T044"], "canonical_name": "2-phosphoglycerate kinase activity", "definition": "Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP. [GOC:bf, InterPro:IPR020872, PMID:2226838, PMID:8159166]"}
{"concept_id": "C3549177", "aliases": ["cDPGS activity", "CPGS activity"], "types": ["T044"], "canonical_name": "cyclic 2,3-diphosphoglycerate synthetase activity", "definition": "Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate. [GOC:crds, PMID:2226838, PMID:8320225, PMID:9811660]"}
{"concept_id": "C3549178", "aliases": [], "types": ["T044"], "canonical_name": "2-iminoacetate synthase activity", "definition": "Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+. [EC:4.1.99.19, GOC:crds, MetaCyc:RXN-11319, PMID:17403671]"}
{"concept_id": "C3549179", "aliases": [], "types": ["T044"], "canonical_name": "2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity", "definition": "Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+. [GOC:crds, InterPro:IPR005903, MetaCyc:RXN-8787, PMID:8437569]"}
{"concept_id": "C3549180", "aliases": ["histone H2A ubiquitination (H2A-K15)"], "types": ["T044"], "canonical_name": "histone H2A-K15 ubiquitination", "definition": "The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin. [GOC:sp, PMID:22713238, PMID:22980979]"}
{"concept_id": "C3549181", "aliases": ["histone H2A ubiquitination (H2A-K13)"], "types": ["T044"], "canonical_name": "histone H2A-K13 ubiquitination", "definition": "The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin. [GOC:sp, PMID:22713238, PMID:22980979]"}
{"concept_id": "C3549182", "aliases": ["cell-cell adhesion involved in mannose-specific flocculation"], "types": ["T044"], "canonical_name": "mannose-specific flocculation", "definition": "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other. [GOC:vw, PMID:9851992]"}
{"concept_id": "C3549183", "aliases": ["cell-cell adhesion involved in galactose-specific flocculation"], "types": ["T044"], "canonical_name": "galactose-specific flocculation", "definition": "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other. [GOC:vw, PMID:22098069]"}
{"concept_id": "C3549184", "aliases": [], "types": ["T044"], "canonical_name": "hydantoin racemase activity", "definition": "Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin. [EC:5.1.99.5, InterPro:IPR015942]"}
{"concept_id": "C3549186", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to L-cysteine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration. [GOC:al]"}
{"concept_id": "C3549187", "aliases": [], "types": ["T043"], "canonical_name": "platelet maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. [CL:0000233, GOC:BHF, GOC:vk]"}
{"concept_id": "C3549188", "aliases": [], "types": ["T043"], "canonical_name": "platelet morphogenesis", "definition": "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. [CL:0000233, GOC:BHF, GOC:vk]"}
{"concept_id": "C3549189", "aliases": [], "types": ["T055"], "canonical_name": "psychomotor behavior", "definition": "The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument. [GOC:nhn, GOC:pr, PMID:17159989, Wikipedia:Psychomotor_learning]"}
{"concept_id": "C3549190", "aliases": [], "types": ["T040"], "canonical_name": "post-anal tail morphogenesis", "definition": "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. [GOC:bf, GOC:kmv, Wikipedia:Chordate]"}
{"concept_id": "C3549191", "aliases": [], "types": ["T038"], "canonical_name": "chitin-based cuticle sclerotization by protein cross-linking", "definition": "The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle. [GOC:bf, GOC:sart]"}
{"concept_id": "C3549192", "aliases": ["chitin-based cuticle hardening by biomineralisation"], "types": ["T038"], "canonical_name": "chitin-based cuticle sclerotization by biomineralization", "definition": "The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate. [GOC:sart]"}
{"concept_id": "C3549193", "aliases": ["lymphocyte adhesion to HEV cell", "lymphocyte adhesion to high endothelial venule"], "types": ["T043"], "canonical_name": "lymphocyte adhesion to endothelial cell of high endothelial venule", "definition": "The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream. [CL:0000542, CL:0002652, GOC:nhn, PMID:19339990, PMID:7679710, Wikipedia:High_endothelial_venules]"}
{"concept_id": "C3549194", "aliases": [], "types": ["T026"], "canonical_name": "viral membrane", "definition": "The lipid bilayer of a virion, a complete fully infectious extracellular virus particle. [GOC:bm]"}
{"concept_id": "C3549195", "aliases": ["CD95 signaling pathway", "Apo-1 signaling pathway", "FasR signaling pathway", "Fas receptor signaling pathway"], "types": ["T044"], "canonical_name": "Fas signaling pathway", "definition": "The series of molecular signals initiated by the binding of a ligand to a Fas receptor on the surface of the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily. [GOC:nhn, PMID:12040174, Wikipedia:Fas_receptor]"}
{"concept_id": "C3549196", "aliases": [], "types": ["T043"], "canonical_name": "dendritic cell migration", "definition": "The movement of a dendritic cell within or between different tissues and organs of the body. [CL:0000451, GOC:nhn, PMID:19339990]"}
{"concept_id": "C3549197", "aliases": [], "types": ["T038"], "canonical_name": "intestinal stem cell homeostasis", "definition": "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells. [GOC:nhn, PMID:22042863]"}
{"concept_id": "C3549198", "aliases": [], "types": ["T038"], "canonical_name": "epidermal stem cell homeostasis", "definition": "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. [CL:1000428, GOC:nhn, PMID:17666529]"}
{"concept_id": "C3549199", "aliases": [], "types": ["T038"], "canonical_name": "hepatocyte homeostasis", "definition": "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. [CL:0000182, GOC:nhn, PMID:19878874]"}
{"concept_id": "C3549205", "aliases": ["FLK-1 signaling pathway", "VEGFR-2 signaling pathway", "VEGFR2 signaling pathway", "KDR signaling pathway"], "types": ["T044"], "canonical_name": "vascular endothelial growth factor receptor-2 signaling pathway", "definition": "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-2 (VEGFR-2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:uh, PMID:12967471, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]"}
{"concept_id": "C3549206", "aliases": [], "types": ["T043"], "canonical_name": "ghrelin secretion", "definition": "The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone. [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin]"}
{"concept_id": "C3549207", "aliases": ["P-factor mating pheromone receptor activity", "P-factor receptor activity"], "types": ["T044"], "canonical_name": "mating-type P-factor pheromone receptor activity", "definition": "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus. [GOC:al, PMID:8314086]"}
{"concept_id": "C3549208", "aliases": ["M-factor receptor activity", "M-factor mating pheromone receptor activity"], "types": ["T044"], "canonical_name": "mating-type M-factor pheromone receptor activity", "definition": "Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus. [GOC:al, PMID:7941744]"}
{"concept_id": "C3549209", "aliases": [], "types": ["T044"], "canonical_name": "peptide pheromone receptor activity", "definition": "Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity. [GOC:al]"}
{"concept_id": "C3549210", "aliases": ["VPg unlinkase activity", "unlinkase activity", "uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity", "Y-pUpN PDE activity"], "types": ["T044"], "canonical_name": "tyrosyl-RNA phosphodiesterase activity", "definition": "Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. [GOC:bf, GOC:sp, PMID:21408223, PMID:22908287]"}
{"concept_id": "C3549211", "aliases": [], "types": ["T043"], "canonical_name": "SREBP-SCAP complex retention in endoplasmic reticulum", "definition": "Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER. [GOC:bf, PMID:16525117]"}
{"concept_id": "C3549212", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to sterol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. [GOC:bf]"}
{"concept_id": "C3549213", "aliases": [], "types": ["T043"], "canonical_name": "response to sterol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. [GOC:bf]"}
{"concept_id": "C3549214", "aliases": ["PI3K catalytic subunit binding"], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase catalytic subunit binding", "definition": "Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. [GOC:bf, PMID:17475214]"}
{"concept_id": "C3549215", "aliases": ["PI3K regulatory subunit binding"], "types": ["T044"], "canonical_name": "phosphatidylinositol 3-kinase regulatory subunit binding", "definition": "Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. [GOC:bf, PMID:20505341]"}
{"concept_id": "C3549216", "aliases": ["chitobiose amidohydrolase activity", "chitin oligosaccharide deacetylase activity", "chitin oligosaccharide amidohydrolase activity"], "types": ["T044"], "canonical_name": "chitin disaccharide deacetylase activity", "definition": "Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate. [EC:3.5.1.105, GOC:imk]"}
{"concept_id": "C3549217", "aliases": ["annealing helicase activity", "nucleoside-triphosphatase activity involved in DNA annealing"], "types": ["T044"], "canonical_name": "ATP-dependent DNA/DNA annealing activity", "definition": "An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule. [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634, PMID:22888405]"}
{"concept_id": "C3549218", "aliases": ["cellular protein localization to M-band", "protein localization to M disc", "protein localization to mesophragma"], "types": ["T043"], "canonical_name": "protein localization to M-band", "definition": "Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere. [GOC:BHF, GOC:rl, PMID:18782775]"}
{"concept_id": "C3549219", "aliases": [], "types": ["T045"], "canonical_name": "16S rRNA (guanine(1516)-N(2))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine. [GOC:imk, PMID:22079366]"}
{"concept_id": "C3549220", "aliases": [], "types": ["T045"], "canonical_name": "23S rRNA (adenine(2030)-N(6))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA. [GOC:imk, PMID:22847818]"}
{"concept_id": "C3549221", "aliases": [], "types": ["T042"], "canonical_name": "embryonic heart tube elongation", "definition": "The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. [GOC:BHF, GOC:gr, PMID:15901664]"}
{"concept_id": "C3549222", "aliases": [], "types": ["T043"], "canonical_name": "ameloblast differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ. [CL:0000059]"}
{"concept_id": "C3549223", "aliases": [], "types": ["T042"], "canonical_name": "umbilical cord morphogenesis", "definition": "The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta. [GOC:BHF, GOC:gr, PMID:15107403]"}
{"concept_id": "C3549224", "aliases": [], "types": ["T042"], "canonical_name": "lymph vessel morphogenesis", "definition": "The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. [GOC:BHF, GOC:gr, PMID:18093989]"}
{"concept_id": "C3549225", "aliases": [], "types": ["T042"], "canonical_name": "atrioventricular canal development", "definition": "The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle. [GOC:BHF, GOC:gr, PMID:14701881, UBERON:0002087, ZFA:0001315]"}
{"concept_id": "C3549226", "aliases": ["M-CSF production"], "types": ["T044"], "canonical_name": "macrophage colony-stimulating factor production", "definition": "The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:vk]"}
{"concept_id": "C3549227", "aliases": ["BCR endocytosis", "BCR receptor internalization"], "types": ["T043"], "canonical_name": "B cell receptor internalization", "definition": "A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell. [GOC:add, GOC:amm]"}
{"concept_id": "C3549228", "aliases": ["recombination-independent ICL repair", "recombination-independent interstrand cross-link repair"], "types": ["T045"], "canonical_name": "non-recombinational interstrand cross-link repair", "definition": "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination. [GOC:vw, PMID:11154259, PMID:22064477]"}
{"concept_id": "C3549229", "aliases": ["recombination-dependent interstrand cross-link repair"], "types": ["T045"], "canonical_name": "recombinational interstrand cross-link repair", "definition": "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. [GOC:vw, PMID:20658649]"}
{"concept_id": "C3549230", "aliases": ["ICL repair"], "types": ["T045"], "canonical_name": "interstrand cross-link repair", "definition": "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. [GOC:vw, PMID:16464006, PMID:22064477]"}
{"concept_id": "C3549231", "aliases": ["response to raised oxygen levels"], "types": ["T043"], "canonical_name": "response to increased oxygen levels", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. [GOC:al]"}
{"concept_id": "C3549232", "aliases": ["cellular response to raised oxygen levels"], "types": ["T043"], "canonical_name": "cellular response to increased oxygen levels", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. [GOC:al]"}
{"concept_id": "C3549233", "aliases": ["response to lowered oxygen levels"], "types": ["T043"], "canonical_name": "response to decreased oxygen levels", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. [GOC:al]"}
{"concept_id": "C3549234", "aliases": [], "types": ["T045"], "canonical_name": "DNA rewinding", "definition": "The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA. [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634]"}
{"concept_id": "C3549235", "aliases": ["cis-autophosphorylation"], "types": ["T044"], "canonical_name": "protein cis-autophosphorylation", "definition": "The phosphorylation by a protein of one or more of its own amino acid residues. [GOC:jsg, PMID:9201908]"}
{"concept_id": "C3549236", "aliases": ["trans-autophosphorylation"], "types": ["T044"], "canonical_name": "protein trans-autophosphorylation", "definition": "The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer. [GOC:jsg, PMID:20516151]"}
{"concept_id": "C3549237", "aliases": ["serine autophosphorylation"], "types": ["T044"], "canonical_name": "peptidyl-serine autophosphorylation", "definition": "The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein. [GOC:pm]"}
{"concept_id": "C3549238", "aliases": [], "types": ["T043"], "canonical_name": "response to ximelagatran", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus. [GOC:hp]"}
{"concept_id": "C3549239", "aliases": [], "types": ["T043"], "canonical_name": "response to iloperidone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus. [GOC:hp]"}
{"concept_id": "C3549240", "aliases": ["linear eisosome"], "types": ["T026"], "canonical_name": "eisosome filament", "definition": "A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1. [GOC:vw, PMID:21900489, PMID:23722945]"}
{"concept_id": "C3549241", "aliases": ["SAGA complex formation"], "types": ["T044"], "canonical_name": "SAGA complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof. [GOC:mah, PMID:10637607, PMID:22456315]"}
{"concept_id": "C3549245", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to L-canavanine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group. [GOC:al]"}
{"concept_id": "C3549246", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein export from nucleus in response to glucose starvation", "definition": "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose. [GOC:al, PMID:3541942]"}
{"concept_id": "C3549247", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen. [GOC:al, PMID:21118960]"}
{"concept_id": "C3549248", "aliases": [], "types": ["T040"], "canonical_name": "response to anticonvulsant", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity. [GOC:hp]"}
{"concept_id": "C3549249", "aliases": [], "types": ["T040"], "canonical_name": "response to antidepressant", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug. [GOC:hp]"}
{"concept_id": "C3549250", "aliases": ["response to fluorouracil", "response to 5-fluoropyrimidine-2,4(1H,3H)-dione"], "types": ["T043"], "canonical_name": "response to 5-fluorouracil", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus. [GOC:hp]"}
{"concept_id": "C3549251", "aliases": [], "types": ["T043"], "canonical_name": "response to lapatinib", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus. [GOC:hp]"}
{"concept_id": "C3549252", "aliases": [], "types": ["T040"], "canonical_name": "response to statin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties. [GOC:hp]"}
{"concept_id": "C3549253", "aliases": ["response to 2',2'-difluorodeoxycytidine", "response to 2'-deoxy-2',2'-difluorocytidine"], "types": ["T043"], "canonical_name": "response to gemcitabine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas. [GOC:hp, Wikipedia:Gemcitabine]"}
{"concept_id": "C3549254", "aliases": ["response to ritalin", "response to MPD", "response to MPH"], "types": ["T043"], "canonical_name": "response to methylphenidate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus. [GOC:hp, Wikipedia:Methylphenidate]"}
{"concept_id": "C3549255", "aliases": ["swimming behaviour"], "types": ["T055"], "canonical_name": "swimming behavior", "definition": "The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water. [GOC:cvs, PMID:16764679]"}
{"concept_id": "C3549256", "aliases": [], "types": ["T045"], "canonical_name": "RNA (guanine-N7)-methylation", "definition": "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule. [GOC:BHF, GOC:rl]"}
{"concept_id": "C3549259", "aliases": [], "types": ["T038"], "canonical_name": "granulysin production", "definition": "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3549260", "aliases": ["TMG cap formation", "2,2,7-trimethylguanosine cap formation", "m(7)G cap hypermethylation", "conversion of m(7)G to m(3)G"], "types": ["T045"], "canonical_name": "7-methylguanosine cap hypermethylation", "definition": "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation. [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984]"}
{"concept_id": "C3549261", "aliases": ["aerobic raffinose breakdown", "aerobic raffinose catabolism", "aerobic raffinose degradation"], "types": ["T044"], "canonical_name": "aerobic raffinose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen. [GOC:al, PMID:10082789]"}
{"concept_id": "C3549262", "aliases": ["MVB formation", "MVB biogenesis", "multivesicular body biogenesis"], "types": ["T043"], "canonical_name": "multivesicular body assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. [GOC:sart, PMID:11566881, PMID:19571114]"}
{"concept_id": "C3549263", "aliases": ["MVB organization"], "types": ["T043"], "canonical_name": "multivesicular body organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. [GOC:sart, PMID:11566881]"}
{"concept_id": "C3549264", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to methylamine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus. [GOC:mah]"}
{"concept_id": "C3549265", "aliases": [], "types": ["T043"], "canonical_name": "response to methylamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus. [GOC:mah]"}
{"concept_id": "C3549266", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to amiloride", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus. [GOC:mah]"}
{"concept_id": "C3549267", "aliases": [], "types": ["T043"], "canonical_name": "response to amiloride", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus. [GOC:mah]"}
{"concept_id": "C3549268", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to menadione", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position. [GOC:al]"}
{"concept_id": "C3549270", "aliases": [], "types": ["T043"], "canonical_name": "peroxisome transport along microtubule", "definition": "The directed movement of a peroxisome along a microtubule, mediated by motor proteins. [GOC:pm, PMID:21525035]"}
{"concept_id": "C3549271", "aliases": [], "types": ["T043"], "canonical_name": "cadmium ion import into vacuole", "definition": "The directed movement of cadmium ions into the vacuole. [GOC:al]"}
{"concept_id": "C3549272", "aliases": ["PC4 import into vacuole"], "types": ["T043"], "canonical_name": "phytochelatin 4 import into vacuole", "definition": "The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond. [GOC:al, PMID:19001374]"}
{"concept_id": "C3549273", "aliases": ["PC3 import into vacuole"], "types": ["T043"], "canonical_name": "phytochelatin 3 import into vacuole", "definition": "The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond. [GOC:al, PMID:19001374]"}
{"concept_id": "C3549274", "aliases": ["PC2 import into vacuole"], "types": ["T043"], "canonical_name": "phytochelatin 2 import into vacuole", "definition": "The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond. [GOC:al, PMID:19001374]"}
{"concept_id": "C3549275", "aliases": ["cellular response to vitamin K3"], "types": ["T043"], "canonical_name": "cellular response to menadione", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position. [GOC:al, Wikipedia:Menadione]"}
{"concept_id": "C3549276", "aliases": [], "types": ["T040"], "canonical_name": "cellular response to neutral pH", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:di, Wikipedia:PH]"}
{"concept_id": "C3549277", "aliases": ["succinic semialdehyde dehydrogenase (NADP+) activity", "succinate semialdehyde:NADP+ oxidoreductase activity", "succinyl semialdehyde dehydrogenase (NADP+) activity", "NADP-dependent succinate-semialdehyde dehydrogenase activity"], "types": ["T044"], "canonical_name": "succinate-semialdehyde dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+. [GOC:bf, RHEA:13213]"}
{"concept_id": "C3549278", "aliases": ["glutamate degradation via gamma aminobutyrate transaminase activity"], "types": ["T044"], "canonical_name": "glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase. [GOC:bf, MetaCyc:PWY-4321]"}
{"concept_id": "C3549279", "aliases": ["glutamate degradation to 4-hydroxybutyrate"], "types": ["T044"], "canonical_name": "glutamate catabolic process to 4-hydroxybutyrate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate. [GOC:bf, MetaCyc:PWY-4321]"}
{"concept_id": "C3549280", "aliases": ["cell wall-enclosed septal periplasm"], "types": ["T026"], "canonical_name": "septal periplasm", "definition": "The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi. [GOC:di, PMID:21564341]"}
{"concept_id": "C3549281", "aliases": [], "types": ["T044"], "canonical_name": "taxoid 7beta-hydroxylase activity", "definition": "Catalysis of the reaction: taxusin + O2 + NADPH + H+ = 7beta-hydroxytaxusin + NADP+ + H2O. [EC:1.14.13.147]"}
{"concept_id": "C3549282", "aliases": [], "types": ["T044"], "canonical_name": "gallate dioxygenase activity", "definition": "Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate. [EC:1.13.11.57, PMID:16030014]"}
{"concept_id": "C3549283", "aliases": [], "types": ["T044"], "canonical_name": "acyl-glucuronidase activity", "definition": "Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate. [GOC:BHF, GOC:vk, PMID:22294686]"}
{"concept_id": "C3549284", "aliases": [], "types": ["T044"], "canonical_name": "acyl glucuronidation", "definition": "The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside). [GOC:BHF, GOC:vk, PMID:12485951, PMID:22294686]"}
{"concept_id": "C3549285", "aliases": [], "types": ["T044"], "canonical_name": "acyl deglucuronidation", "definition": "The removal of glucuronic acid from an acyl-glucuronide. [GOC:BHF, GOC:vk, PMID:22294686]"}
{"concept_id": "C3549286", "aliases": [], "types": ["T044"], "canonical_name": "deglucuronidation", "definition": "The removal of glucuronic acid from a conjugated substrate. [GOC:BHF, GOC:vk, PMID:22294686, PMID:8560473]"}
{"concept_id": "C3549289", "aliases": [], "types": ["T043"], "canonical_name": "granulocyte activation", "definition": "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [CL:0000094, GOC:nhn]"}
{"concept_id": "C3549291", "aliases": ["protein targeting to INM"], "types": ["T044"], "canonical_name": "protein targeting to nuclear inner membrane"}
{"concept_id": "C3549292", "aliases": [], "types": ["T043"], "canonical_name": "mitotic G2 cell cycle arrest in response to glucose starvation", "definition": "The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose. [GOC:al, GOC:mah, GOC:mtg_cell_cycle, PMID:958201]"}
{"concept_id": "C3549294", "aliases": ["cellular response to vitamin B1 deprivation", "cellular response to thiamin starvation"], "types": ["T043"], "canonical_name": "cellular response to vitamin B1 starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine). [GOC:al, Wikipedia:Thiamine]"}
{"concept_id": "C3549295", "aliases": ["homolog recognition region"], "types": ["T026"], "canonical_name": "pairing center", "definition": "A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment. [GOC:kmv, PMID:18597662]"}
{"concept_id": "C3549296", "aliases": ["cellular response to adenine deprivation"], "types": ["T043"], "canonical_name": "cellular response to adenine starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine. [GOC:ai]"}
{"concept_id": "C3549297", "aliases": ["XTP pyrophosphohydrolase activity", "XTPase activity"], "types": ["T044"], "canonical_name": "XTP diphosphatase activity", "definition": "Catalysis of the reaction: XTP + H2O <=> H+ + XDP + monophosphate. [GOC:pz, PMID:16216582, PMID:22531138, RHEA:28610]"}
{"concept_id": "C3549298", "aliases": ["uridine triphosphate pyrophosphohydrolase activity"], "types": ["T044"], "canonical_name": "UTP diphosphatase activity", "definition": "Catalysis of the reaction: UTP + H2O = UMP + diphosphate. [GOC:dgf, PMID:17899088]"}
{"concept_id": "C3549299", "aliases": ["inosine-5'-triphosphate pyrophosphohydrolase activity"], "types": ["T044"], "canonical_name": "ITP diphosphatase activity", "definition": "Catalysis of the reaction: ITP + H2O = IMP + diphosphate. [GOC:dgf, PMID:17899088, PMID:22531138]"}
{"concept_id": "C3549300", "aliases": ["GTP diphosphohydrolase (diphosphate-forming); guanosine 5'-triphosphate pyrophosphohydrolase", "GTP diphosphohydrolase activity"], "types": ["T044"], "canonical_name": "GTP diphosphatase activity", "definition": "Catalysis of the reaction: GTP + H2O = GMP + diphosphate. [GOC:dgf, PMID:22531138, RHEA:29391]"}
{"concept_id": "C3549301", "aliases": [], "types": ["T044"], "canonical_name": "dTTP diphosphatase activity", "definition": "Catalysis of the reaction: dTTP + H2O = dTMP + diphosphate. [GOC:dgf, PMID:22531138, RHEA:28534]"}
{"concept_id": "C3549302", "aliases": ["2'-deoxyguanosine 5'-triphosphate diphosphohydrolase"], "types": ["T044"], "canonical_name": "dGTP diphosphatase activity", "definition": "Catalysis of the reaction: dGTP + H2O = dGMP + diphosphate. [GOC:dgf, PMID:17090528, PMID:22531138, RHEA:28362]"}
{"concept_id": "C3549303", "aliases": ["cellular response to KIT ligand", "cellular response to KITLG", "cellular response to SCF", "cellular response to hematopoietic growth factor KL"], "types": ["T043"], "canonical_name": "cellular response to stem cell factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus. [GOC:uh, PMID:18787413, PMID:7520444]"}
{"concept_id": "C3549304", "aliases": ["response to SCF", "response to KIT ligand", "response to hematopoietic growth factor KL", "response to stem cell factor stimulus"], "types": ["T043"], "canonical_name": "response to stem cell factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus. [GOC:uh]"}
{"concept_id": "C3549305", "aliases": ["contractile ring constriction"], "types": ["T043"], "canonical_name": "contractile ring contraction", "definition": "The process of an actomyosin ring getting smaller in diameter. [GOC:mah, GOC:vw]"}
{"concept_id": "C3549306", "aliases": [], "types": ["T043"], "canonical_name": "contractile ring maintenance", "definition": "The process in which the contractile ring is maintained, typically in response to an internal or external cue. [GOC:mah, GOC:vw]"}
{"concept_id": "C3549307", "aliases": ["protein modification in other organism", "protein modification process in other organism"], "types": ["T044"], "canonical_name": "protein modification process in another organism", "definition": "The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl]"}
{"concept_id": "C3549308", "aliases": [], "types": ["T044"], "canonical_name": "9beta-pimara-7,15-diene oxidase activity", "definition": "Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]. [RHEA:31951]"}
{"concept_id": "C3549312", "aliases": ["histone protein catabolic process"], "types": ["T044"], "canonical_name": "histone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells. [GOC:krc]"}
{"concept_id": "C3549313", "aliases": [], "types": ["T044"], "canonical_name": "abieta-7,13-dien-18-ol hydroxylase activity", "definition": "Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O. [EC:1.14.14.145]"}
{"concept_id": "C3549314", "aliases": [], "types": ["T044"], "canonical_name": "taxoid 14-beta-hydroxylase activity", "definition": "Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O. [EC:1.14.13.146]"}
{"concept_id": "C3549315", "aliases": ["ent-cassadiene C11alpha-hydroxylase activity"], "types": ["T044"], "canonical_name": "ent-cassa-12,15-diene 11-hydroxylase activity", "definition": "Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O. [EC:1.14.14.112]"}
{"concept_id": "C3549316", "aliases": [], "types": ["T044"], "canonical_name": "ent-isokaurene C2-hydroxylase activity", "definition": "Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+. [EC:1.14.14.76]"}
{"concept_id": "C3549317", "aliases": ["3-ketosteroid 9alpha-hydroxylase activity", "KshAB activity"], "types": ["T044"], "canonical_name": "3-ketosteroid 9-alpha-monooxygenase activity", "definition": "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O. [EC:1.14.15.30]"}
{"concept_id": "C3549318", "aliases": [], "types": ["T044"], "canonical_name": "cholest-4-en-3-one 26-monooxygenase activity", "definition": "Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate. [EC:1.14.15.29]"}
{"concept_id": "C3549319", "aliases": ["zymosterol anabolism", "zymosterol formation", "zymosterol biosynthesis", "zymosterol synthesis"], "types": ["T044"], "canonical_name": "zymosterol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol). [GOC:yaf, MetaCyc:PWY-6074]"}
{"concept_id": "C3549320", "aliases": [], "types": ["T044"], "canonical_name": "zymosterol metabolic process", "definition": "The chemical reactions and pathways involving zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol). [GOC:yaf]"}
{"concept_id": "C3549321", "aliases": [], "types": ["T026"], "canonical_name": "muscle cell projection membrane", "definition": "The portion of the plasma membrane surrounding a muscle cell projection. [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]"}
{"concept_id": "C3549322", "aliases": ["myocyte projection"], "types": ["T026"], "canonical_name": "muscle cell projection", "definition": "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]"}
{"concept_id": "C3549323", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity", "definition": "Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O. [EC:1.14.13.140]"}
{"concept_id": "C3549324", "aliases": ["3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming)"], "types": ["T044"], "canonical_name": "3-hydroxyindolin-2-one monooxygenase activity", "definition": "Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O. [EC:1.14.13.139, RHEA:31927]"}
{"concept_id": "C3549325", "aliases": ["indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)"], "types": ["T044"], "canonical_name": "indolin-2-one monooxygenase activity", "definition": "Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O. [EC:1.14.14.157, RHEA:31919]"}
{"concept_id": "C3549326", "aliases": [], "types": ["T044"], "canonical_name": "indole-2-monooxygenase activity", "definition": "Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O. [EC:1.14.13.137, RHEA:31899]"}
{"concept_id": "C3549327", "aliases": [], "types": ["T044"], "canonical_name": "abieta-7,13-diene hydroxylase activity", "definition": "Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O. [EC:1.14.14.144]"}
{"concept_id": "C3549328", "aliases": [], "types": ["T044"], "canonical_name": "abieta-7,13-dien-18-al dehydrogenase activity", "definition": "Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+. [EC:1.2.1.74]"}
{"concept_id": "C3549329", "aliases": [], "types": ["T040"], "canonical_name": "cell growth mode switching, budding to filamentous", "definition": "The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans. [GOC:di]"}
{"concept_id": "C3549330", "aliases": ["early phagocytic vesicle membrane"], "types": ["T026"], "canonical_name": "early phagosome membrane", "definition": "The lipid bilayer surrounding an early phagosome. [GOC:phg]"}
{"concept_id": "C3549331", "aliases": [], "types": ["T044"], "canonical_name": "13-lipoxin reductase activity", "definition": "Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+. [GOC:mw, PMID:10837478]"}
{"concept_id": "C3549332", "aliases": ["asperthecin formation", "asperthecin synthesis", "asperthecin biosynthesis"], "types": ["T044"], "canonical_name": "asperthecin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans. [GOC:di]"}
{"concept_id": "C3549333", "aliases": ["asperthecin breakdown", "asperthecin degradation", "asperthecin catabolism"], "types": ["T044"], "canonical_name": "asperthecin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans. [GOC:di]"}
{"concept_id": "C3549334", "aliases": ["asperthecin metabolism"], "types": ["T044"], "canonical_name": "asperthecin metabolic process", "definition": "The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans. [GOC:di]"}
{"concept_id": "C3549335", "aliases": [], "types": ["T038"], "canonical_name": "plant-type ovary development", "definition": "The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed. [GOC:bf, GOC:tb, ISBN:0879015322]"}
{"concept_id": "C3549336", "aliases": [], "types": ["T038"], "canonical_name": "ureter part of ureteric bud development", "definition": "The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3549337", "aliases": [], "types": ["T038"], "canonical_name": "metanephric part of ureteric bud development", "definition": "The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros. [GOC:mtg_kidney_jan10]"}
{"concept_id": "C3549338", "aliases": [], "types": ["T043"], "canonical_name": "neutral amino acid transmembrane import into vacuole", "definition": "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane. [GOC:mah]"}
{"concept_id": "C3549339", "aliases": [], "types": ["T043"], "canonical_name": "neutral amino acid transmembrane export from vacuole", "definition": "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane. [GOC:mah]"}
{"concept_id": "C3549340", "aliases": [], "types": ["T043"], "canonical_name": "basic amino acid transmembrane export from vacuole", "definition": "The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane. [GOC:mah]"}
{"concept_id": "C3549341", "aliases": [], "types": ["T044"], "canonical_name": "nicotinamide riboside transmembrane transporter activity", "definition": "Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other. [GOC:se]"}
{"concept_id": "C3549342", "aliases": ["GPCR signaling pathway via inhibition of PLC", "G-protein-coupled inhibitory pathway of phospholipase C", "phospholipase C-inhibiting G-protein coupled receptor signaling pathway", "GPCR signaling pathway coupled to inhibition of phospholipase C activity", "PLC-inhibiting GPCR signaling pathway"], "types": ["T044"], "canonical_name": "phospholipase C-inhibiting G protein-coupled receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098]"}
{"concept_id": "C3549344", "aliases": ["positive chemotaxis involved in embryonic olfactory bulb interneuron precursor migration"], "types": ["T043"], "canonical_name": "chemoattraction involved in embryonic olfactory bulb interneuron precursor migration", "definition": "The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C3549345", "aliases": ["negative chemotaxis involved in embryonic olfactory bulb interneuron precursor migration"], "types": ["T043"], "canonical_name": "chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration", "definition": "The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]"}
{"concept_id": "C3549346", "aliases": [], "types": ["T042"], "canonical_name": "medullary reticular formation development", "definition": "The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata. [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, http://www.brainspan.org, Wikipedia:Rhombencephalon]"}
{"concept_id": "C3549347", "aliases": ["glutamate catabolic process to succinate via pyruvate-dependent GABA-transaminase activity"], "types": ["T044"], "canonical_name": "glutamate catabolic process to succinate via succinate semialdehyde", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase. [GOC:bf, GOC:go_curators, MetaCyc:PWY-4321]"}
{"concept_id": "C3549348", "aliases": ["keto-D-gluconate metabolism"], "types": ["T044"], "canonical_name": "keto-D-gluconate metabolic process", "definition": "The chemical reactions and pathways involving keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose. [ISBN:0198506732]"}
{"concept_id": "C3549349", "aliases": ["keto-D-gluconate breakdown", "keto-D-gluconate catabolism", "keto-D-gluconate degradation"], "types": ["T044"], "canonical_name": "keto-D-gluconate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose. [ISBN:0198506732]"}
{"concept_id": "C3549350", "aliases": ["glutamine degradation to fumarate, using glutamate synthase (NADPH)", "glutamine breakdown to fumarate, using glutamate synthase (NADPH)"], "types": ["T044"], "canonical_name": "glutamine catabolic process to fumarate, using glutamate synthase (NADPH)", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13). [GOC:bf, GOC:jl]"}
{"concept_id": "C3549351", "aliases": ["glutamine degradation to fumarate", "glutamine breakdown to fumarate"], "types": ["T044"], "canonical_name": "glutamine catabolic process to fumarate", "definition": "The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate. [GOC:go_curators]"}
{"concept_id": "C3549352", "aliases": [], "types": ["T043"], "canonical_name": "viral DNA cleavage involved in viral genome maturation", "definition": "The cleavage of viral DNA into singular functional units. [ISBN:0121585336]"}
{"concept_id": "C3549353", "aliases": [], "types": ["T040"], "canonical_name": "evasion or tolerance of host defenses by virus"}
{"concept_id": "C3549354", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]"}
{"concept_id": "C3549355", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor. [GOC:mah]"}
{"concept_id": "C3549356", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group. [GOC:ai]"}
{"concept_id": "C3549357", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai]"}
{"concept_id": "C3549358", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. [GOC:ai]"}
{"concept_id": "C3549359", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on NAD(P)H", "definition": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]"}
{"concept_id": "C3549360", "aliases": ["endosome localization", "endosome localisation"], "types": ["T043"], "canonical_name": "endosomal transport", "definition": "The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. [ISBN:0198506732]"}
{"concept_id": "C3549361", "aliases": [], "types": ["T044"], "canonical_name": "energy coupled proton transmembrane transport, against electrochemical gradient", "definition": "The transport of protons across a membrane and against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport. [GOC:mah]"}
{"concept_id": "C3549362", "aliases": [], "types": ["T044"], "canonical_name": "toxic substance binding", "definition": "Binding to a toxic substance, a poisonous substance that causes damage to biological systems. [GOC:bf, GOC:curators, GOC:jl, GOC:pr]"}
{"concept_id": "C3549363", "aliases": [], "types": ["T042"], "canonical_name": "regulation of skeletal muscle contraction via regulation of action potential", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]"}
{"concept_id": "C3549364", "aliases": ["regulation of blood pressure by chemoreceptor signalling pathway"], "types": ["T043"], "canonical_name": "regulation of blood pressure by chemoreceptor signaling pathway", "definition": "A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. [GOC:dph, GOC:tb]"}
{"concept_id": "C3549365", "aliases": ["globoside biosynthesis via lactosylceramide biosynthesis"], "types": ["T044"], "canonical_name": "globoside biosynthetic process via lactosylceramide", "definition": "The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. [GOC:bf, GOC:dph, GOC:tb]"}
{"concept_id": "C3549366", "aliases": ["ganglioside biosynthesis via lactosylceramide biosynthesis"], "types": ["T044"], "canonical_name": "ganglioside biosynthetic process via lactosylceramide", "definition": "The chemical reactions and pathways resulting in the formation of gangliosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. [GOC:bf, GOC:dph, GOC:tb]"}
{"concept_id": "C3549368", "aliases": ["activation of adenylate cyclase activity by glucose involved in G-protein signaling", "activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway", "activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway", "glucose-sensing PKA pathway"], "types": ["T044"], "canonical_name": "adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway", "definition": "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by glucose binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:signaling, GOC:tb]"}
{"concept_id": "C3549369", "aliases": [], "types": ["T038"], "canonical_name": "shoot axis formation", "definition": "The process that gives rise to a shoot axis. This process pertains to the initial formation of a structure from unspecified parts. [GOC:tb]"}
{"concept_id": "C3549370", "aliases": [], "types": ["T038"], "canonical_name": "fruit ripening, non-climacteric", "definition": "A fruit ripening process that does not involve a respiratory burst. [GOC:lr, ISBN:0521587840]"}
{"concept_id": "C3549371", "aliases": [], "types": ["T038"], "canonical_name": "fruit ripening, climacteric", "definition": "A fruit ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset. [GOC:lr, ISBN:0521587840]"}
{"concept_id": "C3549372", "aliases": [], "types": ["T043"], "canonical_name": "response to toxic substance", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr]"}
{"concept_id": "C3549373", "aliases": ["m(7)G RNA capping"], "types": ["T114", "T123"], "canonical_name": "7-methylguanosine RNA capping", "definition": "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. [GOC:vw, PMID:9266685]"}
{"concept_id": "C3549374", "aliases": ["response to water stimulus"], "types": ["T040"], "canonical_name": "response to water", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. [GOC:jl]"}
{"concept_id": "C3549375", "aliases": ["oxidative stress-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway in response to oxidative stress", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. [GOC:ai, GOC:mtg_apoptosis]"}
{"concept_id": "C3549376", "aliases": [], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway in response to DNA damage", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis]"}
{"concept_id": "C3549377", "aliases": [], "types": ["T044"], "canonical_name": "hormone-mediated apoptotic signaling pathway", "definition": "The series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered. [GOC:bf, GOC:mtg_apoptosis]"}
{"concept_id": "C3549378", "aliases": [], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway in response to osmotic stress", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:11454444, PMID:16483738]"}
{"concept_id": "C3549379", "aliases": [], "types": ["T043"], "canonical_name": "granzyme-mediated apoptotic signaling pathway", "definition": "The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells. [GOC:mtg_apoptosis, PMID:17158907]"}
{"concept_id": "C3549380", "aliases": [], "types": ["T038"], "canonical_name": "chitin-based cuticle sclerotization", "definition": "The process of hardening of a chitin-based cuticle. [GOC:dos, GOC:mtg_sensu]"}
{"concept_id": "C3549381", "aliases": [], "types": ["T044"], "canonical_name": "phospholipase C-activating tachykinin receptor signaling pathway", "definition": "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C3549382", "aliases": [], "types": ["T044"], "canonical_name": "phospholipase C-activating serotonin receptor signaling pathway", "definition": "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C3549383", "aliases": ["phospholipase C-activating G-protein coupled glutamate receptor signaling pathway"], "types": ["T044"], "canonical_name": "phospholipase C-activating G protein-coupled glutamate receptor signaling pathway", "definition": "A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]"}
{"concept_id": "C3549384", "aliases": ["protein kinase C-activating G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "protein kinase C-activating G protein-coupled receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). [GOC:mah, GOC:signaling]"}
{"concept_id": "C3549386", "aliases": [], "types": ["T043"], "canonical_name": "cellular component disassembly involved in execution phase of apoptosis", "definition": "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C3549388", "aliases": [], "types": ["T044"], "canonical_name": "creatine transmembrane transporter activity", "definition": "Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. [GOC:ai]"}
{"concept_id": "C3549389", "aliases": [], "types": ["T045"], "canonical_name": "tRNA C5-cytosine methylation", "definition": "The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine. [ISBN:155581073X]"}
{"concept_id": "C3549390", "aliases": [], "types": ["T045"], "canonical_name": "tRNA dihydrouridine synthesis", "definition": "The process whereby a uridine in a transfer RNA is converted to dihydrouridine. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C3549391", "aliases": [], "types": ["T045"], "canonical_name": "tRNA m2,2-guanine biosynthesis", "definition": "The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position. [GOC:hjd, ISBN:155581073X]"}
{"concept_id": "C3549392", "aliases": [], "types": ["T043"], "canonical_name": "synoviocyte proliferation", "definition": "The multiplication or reproduction of type B synoviocytes by cell division, resulting in the expansion of their population. A type B synoviocyte is a fibroblast-like cell found in synovial tissues. [PMID:10770586, PMID:9546370]"}
{"concept_id": "C3549393", "aliases": [], "types": ["T045"], "canonical_name": "tRNA N2-guanine methylation", "definition": "The process whereby a guanine in a tRNA is methylated at the N2 position of guanine. [ISBN:155581073X, ISBN:1555811337]"}
{"concept_id": "C3549394", "aliases": [], "types": ["T045"], "canonical_name": "tRNA N1-guanine methylation", "definition": "The process whereby a guanine in tRNA is methylated at position N1 of the guanine. [ISBN:155581073X, ISBN:1555811337]"}
{"concept_id": "C3549395", "aliases": [], "types": ["T045"], "canonical_name": "tRNA guanine ribose methylation", "definition": "The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety. [ISBN:1555811337]"}
{"concept_id": "C3549396", "aliases": [], "types": ["T045"], "canonical_name": "tRNA 4-thiouridine biosynthesis", "definition": "The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs. [ISBN:155581073X]"}
{"concept_id": "C3549397", "aliases": [], "types": ["T044"], "canonical_name": "bradykinin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin. [PMID:11226291]"}
{"concept_id": "C3549398", "aliases": [], "types": ["T044"], "canonical_name": "tRNA (adenine-C2-)-methyltransferase activity", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA. [PMID:22891362]"}
{"concept_id": "C3549399", "aliases": [], "types": ["T043"], "canonical_name": "desmosome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. [GOC:hjd]"}
{"concept_id": "C3549400", "aliases": [], "types": ["T044"], "canonical_name": "lipid hydroxylation", "definition": "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid. [GOC:hjd, PMID:15658937]"}
{"concept_id": "C3549401", "aliases": [], "types": ["T042"], "canonical_name": "tendon sheath development", "definition": "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. [PMID:20696843]"}
{"concept_id": "C3549402", "aliases": [], "types": ["T040"], "canonical_name": "response to ischemia", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. [GOC:hjd]"}
{"concept_id": "C3549403", "aliases": [], "types": ["T042"], "canonical_name": "trabecular meshwork development", "definition": "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor. [PMID:20568247]"}
{"concept_id": "C3549404", "aliases": [], "types": ["T043"], "canonical_name": "protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "definition": "The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway. [GOC:add, GOC:mtg_apoptosis, PMID:12952892]"}
{"concept_id": "C3549405", "aliases": ["RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription", "transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "definition": "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]"}
{"concept_id": "C3549406", "aliases": ["RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription", "transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "definition": "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]"}
{"concept_id": "C3549410", "aliases": [], "types": ["T045"], "canonical_name": "transcription coactivator binding", "definition": "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. [GOC:krc]"}
{"concept_id": "C3549411", "aliases": [], "types": ["T045"], "canonical_name": "transcription corepressor binding", "definition": "Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc]"}
{"concept_id": "C3549412", "aliases": [], "types": ["T045"], "canonical_name": "transcription cofactor binding"}
{"concept_id": "C3549413", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding"}
{"concept_id": "C3549414", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding"}
{"concept_id": "C3549415", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding"}
{"concept_id": "C3549416", "aliases": ["sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription"], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding"}
{"concept_id": "C3549417", "aliases": ["sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription"], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding"}
{"concept_id": "C3549418", "aliases": ["bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription"}
{"concept_id": "C3549419", "aliases": ["RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding"}
{"concept_id": "C3549420", "aliases": ["RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding"}
{"concept_id": "C3549421", "aliases": ["RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding", "RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding"], "types": ["T045"], "canonical_name": "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription"}
{"concept_id": "C3549422", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding"}
{"concept_id": "C3549423", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional repressor activity, metal ion regulated sequence-specific DNA binding"}
{"concept_id": "C3549424", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional activator activity, metal ion regulated sequence-specific DNA binding"}
{"concept_id": "C3549425", "aliases": ["bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity"}
{"concept_id": "C3549426", "aliases": ["transcription factor activity, metal ion regulated sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "metal ion regulated sequence-specific DNA binding transcription factor activity"}
{"concept_id": "C3549427", "aliases": [], "types": ["T044"], "canonical_name": "phosphorelay response regulator activity", "definition": "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. [GOC:bf, PMID:10966457, PMID:11842140]"}
{"concept_id": "C3549428", "aliases": [], "types": ["T044"], "canonical_name": "phosphorelay sensor kinase activity", "definition": "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]"}
{"concept_id": "C3549430", "aliases": ["G2/M transition checkpoint"], "types": ["T043"], "canonical_name": "G2/M checkpoint"}
{"concept_id": "C3550269", "aliases": [], "types": ["T046"], "definition": "A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells. [GOC:aruk, GOC:bc, PMID:24462092]", "canonical_name": "reactive gliosis"}
{"concept_id": "C3658285", "aliases": ["development of a plant organ", "plant organ development"], "types": ["T042"], "definition": "Transformative processes which occur in cells and tissues to produce differentiated plant organs.", "canonical_name": "plant organ formation"}
{"concept_id": "C3658355", "aliases": [], "types": ["T040"], "definition": "Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.", "canonical_name": "CRISPR-cas system"}
{"concept_id": "C3665580", "aliases": ["immunoglobulin complex location, circulating", "antibody"], "types": ["T026"], "definition": "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. [GOC:add, ISBN:0781735149]", "canonical_name": "immunoglobulin complex, circulating"}
{"concept_id": "C3714516", "aliases": ["TEM", "membrane tetraspanin-enriched microdomain"], "types": ["T026"], "definition": "A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities. [GOC:ans, PMID:19709882, PMID:21930792]", "canonical_name": "tetraspanin-enriched microdomain"}
{"concept_id": "C3714605", "aliases": ["sensory perception of pain"], "types": ["T040"], "definition": "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators]", "canonical_name": "perception of physiological pain"}
{"concept_id": "C3714634", "aliases": ["biological process"], "types": ["T038"], "definition": "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt]", "canonical_name": "biological_process"}
{"concept_id": "C3714709", "aliases": ["LN"], "types": ["T043"], "definition": "A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM. [GOC:dgf, GOC:jl, PMID:22768199]", "canonical_name": "late nucleophagy"}
{"concept_id": "C3714712", "aliases": ["chemolithotrophy", "chemolithotrophie"], "types": ["T044"], "definition": "The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released. [GOC:mah]", "canonical_name": "energy derivation by oxidation of reduced inorganic compounds"}
{"concept_id": "C3714713", "aliases": ["tube cell differentiation"], "types": ["T043"], "canonical_name": "vegetative cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube. [GOC:isa_complete]"}
{"concept_id": "C3714729", "aliases": [], "types": ["T043"], "canonical_name": "electrocardiogram PR interval"}
{"concept_id": "C3714805", "aliases": ["membrane depolarization during atrial cardiac muscle cell action potential", "atrial depolarization"], "types": ["T043"], "definition": "The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]", "canonical_name": "atrial cardiac muscle cell depolarization"}
{"concept_id": "C3714907", "aliases": [], "types": ["T043"], "definition": "The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "canonical_name": "membrane depolarization during action potential"}
{"concept_id": "C3714912", "aliases": ["heterochromatin domain"], "types": ["T026"], "definition": "A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me). [PMID:23151475, PMID:24210919]", "canonical_name": "HOOD"}
{"concept_id": "C3714919", "aliases": ["piccolo-bassoon transport vesicle"], "types": ["T026"], "definition": "A cytoplasmic dense-core vesicle that transports a range of proteins including piccolo, bassoon, N-cadherin and syntaxin. The transported proteins may be associated with the external side of the vesicle, rather than being contained within the vesicle, therefore forming an aggregate of vesicle and proteins. Piccolo-bassoon transport vesicles (or PTVs) range in size from approximately 80 nm in diameter for dense core vesicles to 130 nm by 220 nm in area for aggregates. They are packaged via the trans-Golgi network before being transported through the axon. [GOC:dr, PMID:21569270]", "canonical_name": "PTV"}
{"concept_id": "C3714925", "aliases": ["nucleotide phosphatase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate. [GOC:dos]", "canonical_name": "nucleotide phosphatase activity, acting on free nucleotides"}
{"concept_id": "C3714929", "aliases": ["IscS", "L-cysteine desulfurase complex location", "L-cysteine desulfurase complex"], "types": ["T026"], "definition": "A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer. [GOC:bhm, PMID:11827487]", "canonical_name": "NifS"}
{"concept_id": "C3715231", "aliases": [], "types": ["T045"], "canonical_name": "regulation of retroviral genome replication"}
{"concept_id": "C3811054", "aliases": ["transcription preinitiation complex location", "transcriptional preinitiation complex", "DNA-templated transcriptional preinitiation complex", "transcription preinitiation complex", "transcriptional preinitiation complex location", "DNA-templated transcriptional preinitiation complex location", "transcriptional pre-initiation complex location", "preinitiation complex", "preinitiation complex location", "PIC"], "types": ["T026"], "definition": "A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. [GOC:di, PMID:22751016]", "canonical_name": "transcriptional pre-initiation complex"}
{"concept_id": "C3811389", "aliases": [], "types": ["T044"], "canonical_name": "esterase A"}
{"concept_id": "C3811400", "aliases": ["pre-RC assembly"], "types": ["T044"], "definition": "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. [GOC:bf, GOC:bhm, GOC:jh2]", "canonical_name": "pre-replicative complex assembly"}
{"concept_id": "C3811401", "aliases": ["mycomembrane", "mycolate outer membrane", "MOM"], "types": ["T026"], "definition": "A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria). [GOC:bf, GOC:das, GOC:md, PMID:18316738, PMID:18567661]", "canonical_name": "mycobacterial outer membrane"}
{"concept_id": "C3811628", "aliases": ["ribosome-associated ubiquitin-dependent protein breakdown", "RAD", "ribosome-associated ubiquitin-dependent protein degradation", "ribosome-associated ubiquitin-dependent protein catabolic process"], "types": ["T043"], "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein. [GOC:dgf, PMID:23358411]", "canonical_name": "ribosome-associated ubiquitin-dependent protein catabolism"}
{"concept_id": "C3811681", "aliases": [], "types": ["T038"], "definition": "The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate. [ISBN:0070187517]", "canonical_name": "callus formation"}
{"concept_id": "C3812193", "aliases": ["CoA-synthesizing protein complex", "CoA-synthesizing protein complex location", "CoA-SPC", "coenzyme A-synthesizing protein complex"], "types": ["T026"], "definition": "A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway. [GOC:rb, PMID:23789928]", "canonical_name": "coenzyme A-synthesizing protein complex location"}
{"concept_id": "C3812196", "aliases": ["membrane depolarization during ventricular cardiac muscle cell action potential"], "types": ["T043"], "definition": "The process in which ventricular cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]", "canonical_name": "ventricular depolarization"}
{"concept_id": "C3812197", "aliases": ["catalytic complex", "catalytic complex location", "enzyme complex location"], "types": ["T026"], "definition": "A protein complex which is capable of catalytic activity. [GOC:bhm, GOC:TermGenie, PMID:8077207]", "canonical_name": "enzyme complex"}
{"concept_id": "C3812678", "aliases": [], "types": ["T026"], "canonical_name": "GMP reductase"}
{"concept_id": "C3812680", "aliases": [], "types": ["T026"], "canonical_name": "guanosine monophosphate reductase"}
{"concept_id": "C3812681", "aliases": ["host cell outer membrane", "outer membrane of host cell"], "types": ["T026"], "definition": "A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell. [GOC:bf, GOC:ch]", "canonical_name": "host cell envelope outer membrane"}
{"concept_id": "C3812685", "aliases": ["parasexual reproduction with cellular fusion", "parasexual conjugation with cellular fusion"], "types": ["T043"], "definition": "A type of reproduction in which new individuals are produced from two individuals, with the fusion of two somatic cells. [GOC:di, PMID:26210747]", "canonical_name": "mating"}
{"concept_id": "C3813157", "aliases": ["mRNA-protein complex location", "mRNP complex location", "messenger ribonucleoprotein complex location", "messenger ribonucleoprotein complex", "mRNP complex", "mRNA-protein complex"], "types": ["T026"], "definition": "A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules. [GOC:bf, PMID:15574591, PMID:21915786]", "canonical_name": "mRNP"}
{"concept_id": "C3813159", "aliases": ["periciliary membrane compartment"], "types": ["T026"], "definition": "A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis. [GOC:cilia, GOC:dr, GOC:krc, PMID:22342749]", "canonical_name": "PCMC"}
{"concept_id": "C3813563", "aliases": ["regulation of sporocarp development involved in sexual reproduction", "regulation of perfect stage fruiting body development", "regulation of fruiting body formation involved in sexual reproduction", "regulation of ascus development"], "types": ["T040"], "definition": "Any process that modulates the frequency, rate or extent of sporocarp development involved in sexual reproduction. [GOC:di, GOC:TermGenie, PMID:23480775]", "canonical_name": "regulation of fruiting body development involved in sexual reproduction"}
{"concept_id": "C3813565", "aliases": [], "types": ["T044"], "canonical_name": "viral matrix protein"}
{"concept_id": "C3814045", "aliases": ["post-anaphase microtubule array", "post-anaphase array"], "types": ["T026"], "definition": "A cytoskeletal part that consists of an array of microtubules and associated molecules that forms at the end of anaphase, and in which microtubules are nucleated from an equatorial microtubule organizing center. [PMID:11792817, PMID:17072892, PMID:9601091]", "canonical_name": "PAA"}
{"concept_id": "C3814875", "aliases": ["mTOR complex"], "types": ["T026"], "canonical_name": "mTOR complex location"}
{"concept_id": "C3820479", "aliases": ["UvrB-UvrC complex location"], "types": ["T026"], "canonical_name": "UvrB-UvrC complex"}
{"concept_id": "C3820480", "aliases": ["UvrBC complex location"], "types": ["T026"], "canonical_name": "UvrBC complex"}
{"concept_id": "C3820481", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle"}
{"concept_id": "C3820482", "aliases": [], "types": ["T044"], "canonical_name": "Pmk1 MAPK cell integrity signaling"}
{"concept_id": "C3820483", "aliases": [], "types": ["T044"], "canonical_name": "Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway"}
{"concept_id": "C3820484", "aliases": [], "types": ["T044"], "canonical_name": "PMK1-MAPK signal transduction pathway"}
{"concept_id": "C3820485", "aliases": [], "types": ["T043"], "canonical_name": "ciliary or bacterial-type flagellar motility"}
{"concept_id": "C3820486", "aliases": [], "types": ["T042"], "canonical_name": "intramembranous bone ossification"}
{"concept_id": "C3820487", "aliases": [], "types": ["T044"], "canonical_name": "canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation"}
{"concept_id": "C3820488", "aliases": [], "types": ["T044"], "canonical_name": "serine elastase activity"}
{"concept_id": "C3820489", "aliases": [], "types": ["T044"], "canonical_name": "IFNAR binding"}
{"concept_id": "C3820490", "aliases": [], "types": ["T044"], "canonical_name": "IFNAR1 binding"}
{"concept_id": "C3820491", "aliases": [], "types": ["T044"], "canonical_name": "IFNAR2 binding"}
{"concept_id": "C3820492", "aliases": [], "types": ["T044"], "canonical_name": "pre-RC complex assembly"}
{"concept_id": "C3820493", "aliases": [], "types": ["T042"], "canonical_name": "neuromuscular junction stability"}
{"concept_id": "C3820494", "aliases": [], "types": ["T042"], "canonical_name": "NMJ stability"}
{"concept_id": "C3820495", "aliases": [], "types": ["T044"], "canonical_name": "gurken-activated signaling pathway"}
{"concept_id": "C3820496", "aliases": ["homocysteine transmethylase activity", "homocysteine methyltransferase activity"], "types": ["T044"], "canonical_name": "homocysteine methyltransferase activity"}
{"concept_id": "C3820497", "aliases": [], "types": ["T044"], "canonical_name": "L-homocysteine S-methyltransferase activity"}
{"concept_id": "C3820498", "aliases": [], "types": ["T044"], "canonical_name": "abscisic acid signal transduction"}
{"concept_id": "C3820499", "aliases": [], "types": ["T044"], "canonical_name": "ethylene signal transduction"}
{"concept_id": "C3820500", "aliases": [], "types": ["T044"], "canonical_name": "ethylene signaling pathway"}
{"concept_id": "C3820501", "aliases": ["growth cone collapse"], "types": ["T043"], "canonical_name": "growth cone collapse"}
{"concept_id": "C3820502", "aliases": [], "types": ["T043"], "canonical_name": "caspase-independent cell death"}
{"concept_id": "C3820503", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-activated signaling pathway"}
{"concept_id": "C3820504", "aliases": [], "types": ["T044"], "canonical_name": "4-nitrophenylphosphate phosphohydrolase activity"}
{"concept_id": "C3820505", "aliases": [], "types": ["T044"], "canonical_name": "ecto-p-nitrophenyl phosphatase activity"}
{"concept_id": "C3820506", "aliases": [], "types": ["T044"], "canonical_name": "K-pNPPase activity"}
{"concept_id": "C3820508", "aliases": ["nitrophenyl phosphatase activity"], "types": ["T044"], "canonical_name": "NPPase activity"}
{"concept_id": "C3820510", "aliases": [], "types": ["T044"], "canonical_name": "p-nitrophenylphosphate phosphohydrolase activity"}
{"concept_id": "C3820511", "aliases": [], "types": ["T044"], "canonical_name": "para-nitrophenyl phosphatase activity"}
{"concept_id": "C3820512", "aliases": ["p-nitrophenylphosphatase activity"], "types": ["T044"], "canonical_name": "PNPPase activity"}
{"concept_id": "C3820513", "aliases": [], "types": ["T043"], "canonical_name": "polyadenylated mRNA export from nucleus"}
{"concept_id": "C3820514", "aliases": [], "types": ["T043"], "canonical_name": "bacteriophage maturation"}
{"concept_id": "C3820515", "aliases": [], "types": ["T044"], "canonical_name": "glutathione-independent glyoxalase activity"}
{"concept_id": "C3820518", "aliases": [], "types": ["T026"], "canonical_name": "inner wall zone"}
{"concept_id": "C3820519", "aliases": [], "types": ["T045"], "canonical_name": "termination of RNA polymerase II transcription, polyadenylation-coupled"}
{"concept_id": "C3820520", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic to cytoplasmic side of plasma membrane"}
{"concept_id": "C3820521", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic to cytoplasmic side of plasma membrane"}
{"concept_id": "C3820522", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic to external leaflet of plasma membrane, in periplasmic space"}
{"concept_id": "C3820523", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic to internal leaflet of cell outer membrane"}
{"concept_id": "C3820524", "aliases": [], "types": ["T045"], "canonical_name": "replication fork restart"}
{"concept_id": "C3820525", "aliases": [], "types": ["T045"], "canonical_name": "replication restart"}
{"concept_id": "C3820527", "aliases": [], "types": ["T044"], "canonical_name": "restriction alleviation"}
{"concept_id": "C3820528", "aliases": [], "types": ["T045"], "canonical_name": "cotranscriptional gene silencing by RNA interference machinery"}
{"concept_id": "C3820529", "aliases": [], "types": ["T045"], "canonical_name": "cytoplasmic poly(A)-dependent rRNA catabolic process"}
{"concept_id": "C3820530", "aliases": [], "types": ["T043"], "canonical_name": "opsin transport", "definition": "The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. [GOC:atm, PMID:20238016, PMID:22855808]"}
{"concept_id": "C3820531", "aliases": [], "types": ["T043"], "canonical_name": "ciliary transport of opsin"}
{"concept_id": "C3820532", "aliases": ["fucose 1-epimerase activity", "type-2 mutarotase activity", "alpha-L-fucose 1-epimerase activity"], "types": ["T044"], "canonical_name": "L-fucose mutarotase activity", "definition": "Catalysis of the reaction: alpha-L-fucose = beta-L-fucose. [GOC:crds, PMID:15060078, RHEA:25580]"}
{"concept_id": "C3820533", "aliases": ["gamma-glutamyltranspeptidase activity", "glutathionase activity"], "types": ["T044"], "canonical_name": "glutathione hydrolase activity", "definition": "Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. [EC:3.4.19.13, GOC:imk]"}
{"concept_id": "C3820534", "aliases": ["Kbr, Ex and Mer complex", "Kbr, Ex and Mer complex location", "KEM complex location", "KEM complex", "Kibra-Ex-Mer complex location"], "types": ["T026"], "canonical_name": "Kibra-Ex-Mer complex", "definition": "An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2. [PMID:20159598]"}
{"concept_id": "C3820535", "aliases": ["sodium ion export from cell"], "types": ["T043"], "canonical_name": "sodium ion export across plasma membrane", "definition": "The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689]"}
{"concept_id": "C3820536", "aliases": ["arbuscular mycorrhizas formation", "arbuscular mycorrhizae formation"], "types": ["T070"], "canonical_name": "arbuscular mycorrhizal association", "definition": "A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil. [GOC:sk, Wikipedia:Arbuscular_mycorrhiza]"}
{"concept_id": "C3820537", "aliases": [], "types": ["T070"], "canonical_name": "arbuscular mycorrhizal symbiosis"}
{"concept_id": "C3820538", "aliases": ["calcitriol biosynthesis from calciol", "vitamin D3 activation"], "types": ["T044"], "canonical_name": "calcitriol biosynthetic process from calciol", "definition": "Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol. [GOC:BHF, GOC:rl, PMID:17426122, PMID:20511049]"}
{"concept_id": "C3820539", "aliases": [], "types": ["T044"], "canonical_name": "1alpha,25(OH)2D3 biosynthesis"}
{"concept_id": "C3820540", "aliases": [], "types": ["T044"], "canonical_name": "1alpha,25-dihydroxycholecalciferol biosynthesis"}
{"concept_id": "C3820541", "aliases": [], "types": ["T044"], "canonical_name": "1alpha,25-dihydroxyvitamin D3 biosynthesis"}
{"concept_id": "C3820542", "aliases": ["GlcNAc-P-P-Und synthase activity", "UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity", "UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity", "UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity", "UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity"], "types": ["T044"], "canonical_name": "UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol. [EC:2.7.8.33, GOC:rs]"}
{"concept_id": "C3820543", "aliases": ["pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) activity", "PdxST activity"], "types": ["T044"], "canonical_name": "pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity", "definition": "Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate. [EC:4.3.3.6, GOC:rs]"}
{"concept_id": "C3820544", "aliases": ["flavin:NADH oxidoreductase activity", "NADH-dependent flavin reductase activity"], "types": ["T044"], "canonical_name": "flavin reductase (NADH) activity", "definition": "Catalysis of the reaction: reduced flavin + NAD+ = flavin + NADH + H+. [EC:1.5.1.36, GOC:rs]"}
{"concept_id": "C3820545", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity", "definition": "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O. [EC:1.14.14.12, GOC:rs]"}
{"concept_id": "C3820546", "aliases": ["CDPase activity"], "types": ["T044"], "canonical_name": "cytidine-diphosphatase activity", "definition": "Catalysis of the reaction: CDP + H2O = CMP + phosphate. [GOC:al, RHEA:64880]"}
{"concept_id": "C3820548", "aliases": ["bacterial nucleoid DNA packaging"], "types": ["T045"], "canonical_name": "bacterial nucleoid packaging", "definition": "A process in which chromosomal DNA and associated proteins organize into a compact, orderly bacterial nucleoid. Often resulting in DNA supercoiling. [GOC:bf, GOC:bhm, PMID:17097674, PMID:17360520]"}
{"concept_id": "C3820549", "aliases": [], "types": ["T045"], "canonical_name": "chromosomal compaction"}
{"concept_id": "C3820550", "aliases": [], "types": ["T045"], "canonical_name": "nucleoid compaction"}
{"concept_id": "C3820551", "aliases": [], "types": ["T045"], "canonical_name": "prokaryotic DNA condensation"}
{"concept_id": "C3820552", "aliases": [], "types": ["T044"], "canonical_name": "pre-replication complex assembly"}
{"concept_id": "C3820553", "aliases": ["bacterial pre-replicative complex location", "bacterial pre-RC"], "types": ["T026"], "canonical_name": "bacterial pre-replicative complex", "definition": "A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, Wikipedia:Pre-replication_complex]"}
{"concept_id": "C3820554", "aliases": ["bacterial pre-RC assembly", "bacterial pre-replicative complex assembly"], "types": ["T044"], "canonical_name": "pre-replicative complex assembly involved in bacterial-type DNA replication", "definition": "The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, PMID:21895796]"}
{"concept_id": "C3820555", "aliases": [], "types": ["T026"], "canonical_name": "medial cortex septin ring", "definition": "A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. [GOC:vw, PMID:16009555]"}
{"concept_id": "C3820556", "aliases": ["C-C motif chemokine 20 production", "CCL20 production", "CCL-20 production"], "types": ["T040"], "canonical_name": "chemokine (C-C motif) ligand 20 production", "definition": "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:jc]"}
{"concept_id": "C3820557", "aliases": [], "types": ["T044"], "canonical_name": "thiocyanate peroxidase activity", "definition": "Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate. [GOC:pm, PMID:12626341]"}
{"concept_id": "C3820558", "aliases": ["amylase release"], "types": ["T043"], "canonical_name": "amylase secretion", "definition": "The controlled release of amylase from a cell. [GOC:jc, PMID:19028687]"}
{"concept_id": "C3820559", "aliases": [], "types": ["T043"], "canonical_name": "pancreatic amylase secretion", "definition": "The controlled release of amylase from a cell of the pancreas. [GOC:jc, PMID:19028687]"}
{"concept_id": "C3820560", "aliases": ["Mum2, Ime4, and Slz1 complex", "WMM complex location", "RNA N6-methyladenosine methyltransferase complex location", "MIS complex location", "Mum2, Ime4, and Slz1 complex location", "WMM complex", "MIS complex"], "types": ["T026"], "canonical_name": "RNA N6-methyladenosine methyltransferase complex", "definition": "A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B). [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715, PMID:24407421, PMID:29507755, PMID:29535189, PMID:29547716]"}
{"concept_id": "C3820561", "aliases": ["formate:quinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "formate dehydrogenase (quinone) activity", "definition": "Catalysis of the reaction: formate + a quinone = CO2 + a quinol. [GOC:bhm, RHEA:48592]"}
{"concept_id": "C3820562", "aliases": ["formate dehydrogenase-N activity"], "types": ["T044"], "canonical_name": "Fdh-N activity"}
{"concept_id": "C3820564", "aliases": ["LAT signalosome", "linker for activation of T cells signalosome"], "types": ["T026"], "canonical_name": "TCR signalosome", "definition": "A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology. [GOC:krc, PMID:17534068, PMID:20107804, PMID:22426112]"}
{"concept_id": "C3820565", "aliases": ["linker for activation of T cells signalosome assembly", "LAT signalosome assembly"], "types": ["T044"], "canonical_name": "TCR signalosome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome. [GOC:krc, PMID:22426112]"}
{"concept_id": "C3820566", "aliases": ["sNPF receptor activity"], "types": ["T044"], "canonical_name": "short neuropeptide F receptor activity", "definition": "Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide. [GOC:ha, PMID:16330127, PMID:21440021]"}
{"concept_id": "C3820567", "aliases": ["PK receptor activity"], "types": ["T044"], "canonical_name": "pyrokinin receptor activity", "definition": "Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation. [GOC:ha, PMID:12951076, PMID:19186060]"}
{"concept_id": "C3820568", "aliases": ["ATPase involved in positive regulation of proteasomal protein catabolic process", "proteasome-activating ATPase activity", "proteasomal ATPase activity"], "types": ["T044"], "canonical_name": "proteasome-activating activity", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. [GOC:rb, PMID:11430818]"}
{"concept_id": "C3820569", "aliases": [], "types": ["T044"], "canonical_name": "proteasome channel gating activity"}
{"concept_id": "C3820570", "aliases": [], "types": ["T044"], "canonical_name": "proteasome channel opening activity"}
{"concept_id": "C3820571", "aliases": [], "types": ["T044"], "canonical_name": "arachidonate 8(S)-lipoxygenase activity", "definition": "Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. [GOC:lb, PMID:10625675, RHEA:38675]"}
{"concept_id": "C3820572", "aliases": [], "types": ["T044"], "canonical_name": "8(S)-lipoxygenase activity"}
{"concept_id": "C3820573", "aliases": [], "types": ["T044"], "canonical_name": "8-lipoxygenase (S-type)"}
{"concept_id": "C3820576", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of cell outer membrane", "definition": "The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos, GOC:md]"}
{"concept_id": "C3820577", "aliases": [], "types": ["T026"], "canonical_name": "anchored to cell outer membrane"}
{"concept_id": "C3820578", "aliases": ["anchored to internal side of cell outer membrane"], "types": ["T026"], "canonical_name": "anchored component of periplasmic side of cell outer membrane", "definition": "The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only. [GOC:dos, GOC:md]"}
{"concept_id": "C3820579", "aliases": [], "types": ["T026"], "canonical_name": "anchored to periplasmic side of cell outer membrane"}
{"concept_id": "C3820580", "aliases": ["histone lysine N-acetyltransferase activity (H3-K14 specific)"], "types": ["T044"], "canonical_name": "histone acetyltransferase activity (H3-K14 specific)", "definition": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14). [GOC:vw, PMID:21289066]"}
{"concept_id": "C3820581", "aliases": ["H3-K14 histone acetyltransferase complex location", "histone H3 Lys 14 (H3K14) acetyltransferase complex location", "histone H3 Lys 14 (H3K14) acetyltransferase complex", "histone H3K14 acetyltransferase complex location", "H3-K14 histone acetyltransferase complex", "histone acetyltransferase complex (H3-K14 specific)", "histone H3K14 acetyltransferase complex", "histone H3-K14 acetyltransferase complex location", "histone acetyltransferase complex location (H3-K14 specific)"], "types": ["T026"], "canonical_name": "histone H3-K14 acetyltransferase complex", "definition": "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3. [GOC:vw, PMID:21289066]"}
{"concept_id": "C3820582", "aliases": ["Mst2 histone acetyltransferase complex location", "Mst2 complex location", "Mst2 histone H3K14 acetyltransferase complex location", "Mst2 H3K14 acetyltransferase complex", "Mst2 complex", "Mst2 histone H3K14 acetyltransferase complex", "Mst2 H3K14 acetyltransferase complex location"], "types": ["T026"], "canonical_name": "Mst2 histone acetyltransferase complex", "definition": "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6. [GOC:vw, PMID:21289066]"}
{"concept_id": "C3820583", "aliases": ["H-NS-Cnu complex location"], "types": ["T026"], "canonical_name": "H-NS-Cnu complex", "definition": "A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes. [GOC:bhm, PMID:18189420, PMID:22358512]"}
{"concept_id": "C3820584", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA:oxalate CoA-transferase", "definition": "Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA. [GOC:imk, PMID:23935849]"}
{"concept_id": "C3820585", "aliases": ["H3-R26 citrullination"], "types": ["T044"], "canonical_name": "histone-arginine deiminase activity (H3-R26 specific)", "definition": "Catalysis of the reaction: H2O + histone 3 L-arginyl (position 26)= histone 3 L-citrullyl (position 26) + NH4+, resulting in histone H3 citrullination at position 26. [PMID:15339660]"}
{"concept_id": "C3820587", "aliases": [], "types": ["T045"], "canonical_name": "regulation of tRNA stability", "definition": "Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs. [GOC:aa, PMID:21502523, PMID:23572593]"}
{"concept_id": "C3820588", "aliases": [], "types": ["T045"], "canonical_name": "tRNA stabilization", "definition": "Prevention of degradation of tRNA molecules. [GOC:aa, GOC:bf, PMID:20459084]"}
{"concept_id": "C3820589", "aliases": [], "types": ["T045"], "canonical_name": "tRNA destabilization", "definition": "Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes. [GOC:aa, GOC:bf]"}
{"concept_id": "C3820590", "aliases": ["intrinsic to MOM", "intrinsic to mycomembrane", "intrinsic to mycolate outer membrane"], "types": ["T026"], "canonical_name": "intrinsic component of mycolate outer membrane", "definition": "The component of the mycolate outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:md]"}
{"concept_id": "C3820591", "aliases": ["integral to mycomembrane", "integral to MOM"], "types": ["T026"], "canonical_name": "integral component of mycolate outer membrane", "definition": "The component of the mycolate outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:md]"}
{"concept_id": "C3820592", "aliases": [], "types": ["T026"], "canonical_name": "integral to mycolate outer membrane"}
{"concept_id": "C3820593", "aliases": ["extrinsic to mycomembrane", "extrinsic to MOM"], "types": ["T026"], "canonical_name": "extrinsic component of mycolate outer membrane", "definition": "The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:md]"}
{"concept_id": "C3820594", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic to mycolate outer membrane"}
{"concept_id": "C3820595", "aliases": ["extrinsic to external side of MOM", "extrinsic to external side of mycomembrane", "extrinsic to external side of mycolate outer membrane"], "types": ["T026"], "canonical_name": "extrinsic component of external side of mycolate outer membrane", "definition": "The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. [GOC:md]"}
{"concept_id": "C3820596", "aliases": ["all-trans-heptaprenyl-diphosphate synthase activity", "heptaprenyl pyrophosphate synthase activity", "HepPP synthase activity", "heptaprenyl pyrophosphate synthetase activity"], "types": ["T044"], "canonical_name": "heptaprenyl diphosphate synthase activity", "definition": "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate. [RHEA:27794]"}
{"concept_id": "C3820597", "aliases": [], "types": ["T044"], "canonical_name": "hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity", "definition": "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate. [EC:2.5.1.83, RHEA:27559]"}
{"concept_id": "C3820598", "aliases": [], "types": ["T044"], "canonical_name": "L-phosphoserine phosphatase activity", "definition": "Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid. [PMID:25037224, PMID:9188776, RHEA:21208]"}
{"concept_id": "C3820600", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-undecaprenyl-phosphate mannosyltransferase activity", "definition": "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP. [RHEA:28118]"}
{"concept_id": "C3820601", "aliases": [], "types": ["T044"], "canonical_name": "adenosylcobinamide kinase (GTP-specific) activity", "definition": "Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+. [RHEA:15765]"}
{"concept_id": "C3820602", "aliases": [], "types": ["T044"], "canonical_name": "adenosylcobinamide kinase (ATP-specific) activity", "definition": "Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+. [RHEA:15769]"}
{"concept_id": "C3820603", "aliases": [], "types": ["T044"], "canonical_name": "all-trans undecaprenol kinase activity", "definition": "Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+. [RHEA:23752]"}
{"concept_id": "C3820604", "aliases": [], "types": ["T044"], "canonical_name": "di-trans, poly-cis-undecaprenol kinase activity", "definition": "Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+. [RHEA:28122]"}
{"concept_id": "C3820605", "aliases": [], "types": ["T044"], "canonical_name": "ditrans,polycis-undecaprenol kinase activity"}
{"concept_id": "C3820606", "aliases": [], "types": ["T044"], "canonical_name": "nitronate monooxygenase (FMN-linked) activity", "definition": "Catalysis of the reaction: ethylnitronate + FMNH(2) + O(2) = acetaldehyde + FMN + H(2)O + H(+) + nitrite. [RHEA:26458]"}
{"concept_id": "C3820607", "aliases": [], "types": ["T044"], "canonical_name": "K48-linked polyubiquitin modification-dependent protein binding", "definition": "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein. [GOC:al, PMID:20739285]"}
{"concept_id": "C3820608", "aliases": ["Isw1a complex location"], "types": ["T026"], "canonical_name": "Isw1a complex", "definition": "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p. [GOC:jd, PMID:12482963]"}
{"concept_id": "C3820609", "aliases": ["Isw1b complex location"], "types": ["T026"], "canonical_name": "Isw1b complex", "definition": "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p. [GOC:jd, PMID:12482963]"}
{"concept_id": "C3820610", "aliases": ["preservation of lens transparency", "maintenance of ocular lens transparency"], "types": ["T040"], "canonical_name": "maintenance of lens transparency", "definition": "A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina. [GOC:nhn, PMID:22095752]"}
{"concept_id": "C3820611", "aliases": [], "types": ["T044"], "canonical_name": "2-dehydropantolactone reductase activity", "definition": "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. [RHEA:18981]"}
{"concept_id": "C3820612", "aliases": [], "types": ["T044"], "canonical_name": "dermatan 6-sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate. [EC:2.8.2.33, GOC:bf, KEGG_REACTION:R07288]"}
{"concept_id": "C3820613", "aliases": ["mitochondrial calcium ion import"], "types": ["T043"], "canonical_name": "calcium ion import into mitochondrion"}
{"concept_id": "C3820614", "aliases": ["NSC division"], "types": ["T043"], "canonical_name": "neuronal stem cell division", "definition": "The self-renewing division of a neuronal stem cell. [CL:0000047, GOC:nhn]"}
{"concept_id": "C3820615", "aliases": ["myofibroblast cell differentiation"], "types": ["T043"], "canonical_name": "myofibroblast differentiation", "definition": "The process in which an undifferentiated cell acquires the features of a myofibroblast cell. [CL:0000186, GOC:nhn]"}
{"concept_id": "C3820616", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to sugar-phosphate stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate. [GOC:am, PMID:17383224]"}
{"concept_id": "C3820617", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to presence of non-metabolizable sugars"}
{"concept_id": "C3820618", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to glucose-phosphate stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate. [GOC:am, PMID:17383224]"}
{"concept_id": "C3820619", "aliases": [], "types": ["T045"], "canonical_name": "polyuridylation-dependent decapping of nuclear-transcribed mRNA", "definition": "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end. [GOC:vw, PMID:19430462]"}
{"concept_id": "C3820620", "aliases": [], "types": ["T045"], "canonical_name": "uridylation-dependent decapping of nuclear-transcribed mRNA"}
{"concept_id": "C3820621", "aliases": [], "types": ["T045"], "canonical_name": "cap mRNA methylation", "definition": "Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a 5'-capped mRNA. [GOC:bf, PMID:20713356]"}
{"concept_id": "C3820622", "aliases": ["transitive RNAi"], "types": ["T045"], "canonical_name": "transitive RNA interference", "definition": "An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence. [GOC:pf, PMID:11719187, PMID:12554873, PMID:23724097, PMID:24369430]"}
{"concept_id": "C3820623", "aliases": ["growth factor complex location"], "types": ["T026"], "canonical_name": "growth factor complex", "definition": "A protein complex that has growth factor activity. [GOC:bhm]"}
{"concept_id": "C3820624", "aliases": ["Fe-S transferase activity"], "types": ["T044"], "canonical_name": "iron-sulfur transferase activity", "definition": "Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor). [GOC:bhm]"}
{"concept_id": "C3820625", "aliases": [], "types": ["T026"], "definition": "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope. [GOC:krc, PMID:15854042]", "canonical_name": "keratohyalin granule"}
{"concept_id": "C3820626", "aliases": ["HGF binding"], "types": ["T044"], "canonical_name": "hepatocyte growth factor binding", "definition": "Binding to a hepatocyte growth factor. [GOC:curators]"}
{"concept_id": "C3820627", "aliases": ["envelope stress response"], "types": ["T043"], "canonical_name": "cellular response to cell envelope stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope. [GOC:imk, PMID:15101969, PMID:15882407]"}
{"concept_id": "C3820628", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt-activated signaling pathway by Wnt receptor internalization"}
{"concept_id": "C3820630", "aliases": ["nerve growth factor signalling pathway", "NGF signaling pathway"], "types": ["T044"], "canonical_name": "nerve growth factor signaling pathway", "definition": "The series of molecular signals initiated by nerve growth factor (NGF) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, PMID:11520933]"}
{"concept_id": "C3820631", "aliases": [], "types": ["T044"], "canonical_name": "bile acid receptor activity", "definition": "Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile. [GOC:bf, PMID:10334992, PMID:12718893]"}
{"concept_id": "C3820632", "aliases": ["G-protein coupled bile acid receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled bile acid receptor activity", "definition": "Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, PMID:12524422]"}
{"concept_id": "C3820633", "aliases": [], "types": ["T044"], "canonical_name": "cell surface bile acid receptor"}
{"concept_id": "C3820634", "aliases": [], "types": ["T044"], "canonical_name": "membrane bile acid receptor activity"}
{"concept_id": "C3820635", "aliases": [], "types": ["T043"], "canonical_name": "bile acid signaling pathway", "definition": "The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:signaling, PMID:12016314]"}
{"concept_id": "C3820636", "aliases": [], "types": ["T044"], "canonical_name": "cell surface bile acid receptor signaling pathway", "definition": "The series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, PMID:12419312, PMID:19442546]"}
{"concept_id": "C3820637", "aliases": [], "types": ["T044"], "canonical_name": "membrane bile acid receptor signaling pathway"}
{"concept_id": "C3820638", "aliases": [], "types": ["T044"], "canonical_name": "intracellular bile acid receptor signaling pathway", "definition": "The series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, PMID:10334992]"}
{"concept_id": "C3820639", "aliases": [], "types": ["T044"], "canonical_name": "nuclear bile acid receptor signaling pathway"}
{"concept_id": "C3820640", "aliases": ["LCA receptor activity"], "types": ["T044"], "canonical_name": "lithocholic acid receptor activity", "definition": "Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity. [GOC:bf, PMID:12016314, PMID:12419312]"}
{"concept_id": "C3820641", "aliases": ["PRR", "PRR activity"], "types": ["T044"], "definition": "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response. [GOC:ar, GOC:bf]", "canonical_name": "pattern recognition receptor activity"}
{"concept_id": "C3820642", "aliases": ["CCK signaling"], "types": ["T044"], "canonical_name": "cholecystokinin signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by cholecystokinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:11181948]"}
{"concept_id": "C3820643", "aliases": [], "types": ["T044"], "canonical_name": "cholecystokinin receptor signaling pathway"}
{"concept_id": "C3820644", "aliases": ["Npn signaling"], "types": ["T044"], "canonical_name": "neuropilin signaling pathway", "definition": "The series of molecular signals initiated by an extracellular ligand binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, PMID:12852851]"}
{"concept_id": "C3820645", "aliases": ["VEGF-Npn-1 signaling", "vascular endothelial growth factor-activated neuropilin signaling pathway"], "types": ["T044"], "canonical_name": "VEGF-activated neuropilin signaling pathway", "definition": "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:rl, PMID:12852851]"}
{"concept_id": "C3820649", "aliases": [], "types": ["T044"], "canonical_name": "Nrp ligand"}
{"concept_id": "C3820650", "aliases": ["GIP signaling", "glucose-dependent insulinotropic polypeptide signaling", "gastric inhibitory polypeptide receptor signaling pathway"], "types": ["T044"], "canonical_name": "gastric inhibitory peptide signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by gastric inhibitory peptide (GIP) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, PMID:15955806]"}
{"concept_id": "C3820651", "aliases": ["TXA2 signaling", "TXA(2) receptor signaling"], "types": ["T044"], "canonical_name": "thromboxane A2 signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by thromboxane A2 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, PMID:15893915]"}
{"concept_id": "C3820652", "aliases": ["thyrotropin signaling pathway", "TSH signaling pathway"], "types": ["T044"], "canonical_name": "thyroid-stimulating hormone signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by thyroid-stimulating hormone (thyrotropin) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:gap, PMID:10809230]"}
{"concept_id": "C3820653", "aliases": ["uPA signaling pathway"], "types": ["T044"], "canonical_name": "urokinase plasminogen activator signaling pathway", "definition": "The series of molecular signals initiated by urokinase plasminogen activator binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:gap, PMID:9417082]"}
{"concept_id": "C3820654", "aliases": ["type III interferon-activated signaling pathway"], "types": ["T043"], "canonical_name": "type III interferon signaling pathway", "definition": "The series of molecular signals initiated by type III interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far. [GOC:pg, GOC:signaling]"}
{"concept_id": "C3820655", "aliases": [], "types": ["T043"], "canonical_name": "interferon lambda signaling pathway"}
{"concept_id": "C3820656", "aliases": ["type I interferon receptor complex location"], "types": ["T026"], "canonical_name": "type I interferon receptor complex", "definition": "A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). [GOC:cjm, GOC:signaling, PMID:17502368]"}
{"concept_id": "C3820657", "aliases": ["interferon-alpha/beta receptor complex location"], "types": ["T026"], "canonical_name": "interferon-alpha/beta receptor complex"}
{"concept_id": "C3820658", "aliases": [], "types": ["T044"], "canonical_name": "auxin receptor activity", "definition": "Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone). [GOC:signaling, PMID:15917797]"}
{"concept_id": "C3820659", "aliases": ["C2H4 receptor activity"], "types": ["T044"], "canonical_name": "ethylene receptor activity", "definition": "Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity. [GOC:signaling, PMID:22467798, PMID:24012247]"}
{"concept_id": "C3820660", "aliases": [], "types": ["T044"], "canonical_name": "ethylene response sensor"}
{"concept_id": "C3820661", "aliases": [], "types": ["T044"], "canonical_name": "ethylene receptor histidine kinase activity", "definition": "Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. [GOC:signaling, PMID:22467798]"}
{"concept_id": "C3820662", "aliases": ["TOR signaling complex", "TOR signaling complex location", "target of rapamycin complex", "target of rapamycin complex location", "TOR complex location"], "types": ["T026"], "canonical_name": "TOR complex", "definition": "A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. [Wikipedia:MTORC1, Wikipedia:MTORC2]"}
{"concept_id": "C3820663", "aliases": ["TORC1 signal transduction"], "types": ["T044"], "canonical_name": "TORC1 signaling", "definition": "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. [GOC:lb]"}
{"concept_id": "C3820664", "aliases": ["TORC2 signal transduction"], "types": ["T044"], "canonical_name": "TORC2 signaling", "definition": "A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. [GOC:lb]"}
{"concept_id": "C3820666", "aliases": [], "types": ["T040"], "canonical_name": "Rex exclusion"}
{"concept_id": "C3820667", "aliases": [], "types": ["T043"], "canonical_name": "induction by virus of host caspase activity"}
{"concept_id": "C3820668", "aliases": ["fusion of virus membrane with host endosomal membrane"], "types": ["T044"], "canonical_name": "fusion of virus membrane with host endosome membrane", "definition": "Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell. [GOC:bf, UniProtKB-KW:KW-1170, VZ:992]"}
{"concept_id": "C3820669", "aliases": [], "types": ["T044"], "canonical_name": "viral entry into host cell via caveolin-mediated endocytosis followed by membrane fusion with the endosome membrane"}
{"concept_id": "C3820670", "aliases": [], "types": ["T044"], "canonical_name": "viral entry into host cell via endocytosis followed by membrane fusion with host endosome"}
{"concept_id": "C3820671", "aliases": [], "types": ["T044"], "canonical_name": "viral entry into host cell via endocytosis followed by membrane fusion with the endosome membrane"}
{"concept_id": "C3820675", "aliases": [], "types": ["T045"], "canonical_name": "modulation by virus of host gene expression", "definition": "The process in which a virus effects a change in gene expression in its host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. [GOC:bf]"}
{"concept_id": "C3820676", "aliases": [], "types": ["T045"], "canonical_name": "regulation by virus of host gene expression"}
{"concept_id": "C3820677", "aliases": ["host gene expression shutoff by virus"], "types": ["T045"], "canonical_name": "suppression by virus of host gene expression", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. [UniProtKB-KW:KW-1190, VZ:1582]"}
{"concept_id": "C3820678", "aliases": ["TBK1-IKBKE-DDX3 complex", "TBK1-IKBKE-DDX3 complex location", "TBK1-IKKE-DDX3 complex location"], "types": ["T026"], "canonical_name": "TBK1-IKKE-DDX3 complex", "definition": "A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3. [PMID:18636090, VZ:719]"}
{"concept_id": "C3820680", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of virion", "definition": "The action of a molecule that contributes to the structural integrity of a virion. [GOC:bf, GOC:jl]"}
{"concept_id": "C3820681", "aliases": [], "types": ["T026"], "canonical_name": "host organelle outer membrane", "definition": "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell. [GOC:bf, GOC:ch]"}
{"concept_id": "C3820682", "aliases": ["fusion of virus membrane with host membrane during viral entry"], "types": ["T044"], "canonical_name": "membrane fusion involved in viral entry into host cell", "definition": "Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell. [GOC:bf, GOC:jl, UniProtKB-KW:KW-1168]"}
{"concept_id": "C3820683", "aliases": [], "types": ["T044"], "canonical_name": "fusion of virus membrane with host membrane"}
{"concept_id": "C3820684", "aliases": [], "types": ["T044"], "canonical_name": "viral entry into host cell via membrane fusion"}
{"concept_id": "C3820685", "aliases": ["viral penetration via lysis of host organellar membrane"], "types": ["T038"], "canonical_name": "lysis of host organelle involved in viral entry into host cell", "definition": "The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm. [GOC:bf, GOC:jl, UniProtKB-KW:KW-1174, VZ:984]"}
{"concept_id": "C3820686", "aliases": [], "types": ["T043"], "canonical_name": "viral entry into host cell via endosome membrane lysis"}
{"concept_id": "C3820687", "aliases": [], "types": ["T038"], "canonical_name": "viral entry into host cell via lysis of host organelle membrane"}
{"concept_id": "C3820688", "aliases": [], "types": ["T043"], "canonical_name": "viral membrane-lytic protein"}
{"concept_id": "C3820689", "aliases": ["viral penetration via host endosomal membrane disruption by virus", "viral penetration via permeabilization of host organellar membrane", "viral penetration via perforation of host organellar membrane by virus"], "types": ["T038"], "canonical_name": "permeabilization of host organelle membrane involved in viral entry into host cell", "definition": "Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm. [GOC:bf, GOC:jl, UniProtKB-KW:KW-1173, VZ:985]"}
{"concept_id": "C3820690", "aliases": [], "types": ["T038"], "canonical_name": "viral entry into host cell via permeabilization of host organelle membrane"}
{"concept_id": "C3820691", "aliases": [], "types": ["T038"], "canonical_name": "viral membrane-penetration protein"}
{"concept_id": "C3820692", "aliases": ["viral attachment to host cell pilus", "pilus-mediated viral adsorption onto host cell", "pilus-adsorption protein"], "types": ["T043"], "canonical_name": "virion attachment to host cell pilus", "definition": "The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side. [UniProtKB-KW:KW-1175, VZ:981]"}
{"concept_id": "C3820693", "aliases": [], "types": ["T043"], "canonical_name": "pilus-mediated viral attachment to host cell"}
{"concept_id": "C3820694", "aliases": [], "types": ["T043"], "canonical_name": "viral entry into host cell via pilus retraction", "definition": "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of a virion-bound pilus. [GOC:bf, GOC:jl, VZ:981]"}
{"concept_id": "C3820695", "aliases": [], "types": ["T043"], "canonical_name": "viral entry into host cell via pilus basal pore", "definition": "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of the virion-bound pilus, followed by entry of the viral genome into the host cell through the pilus basal pore. Filamentous bacteriophages absorb to the tip of the F-pili and can enter the bacterial cell in this way. [GOC:bf, GOC:jl]"}
{"concept_id": "C3820696", "aliases": [], "types": ["T043"], "canonical_name": "filamentous viral entry into host cell via pilus retraction"}
{"concept_id": "C3820697", "aliases": [], "types": ["T043"], "canonical_name": "viral entry into host cell via pilus retraction and membrane fusion", "definition": "The uptake of a virus into a host cell which occurs via retraction of the viral-bound pilus to bring the virus in contact with the host cell membrane, followed by fusion of the bacteriophage membrane with the host outer membrane. [GOC:bf, GOC:jl, PMID:20427561, VZ:981]"}
{"concept_id": "C3820698", "aliases": [], "types": ["T026"], "canonical_name": "viral capsid, turret", "definition": "A turret-like appendage formed at the vertices of an icosahedral capsid. [GOC:jh2, PMID:20592081]"}
{"concept_id": "C3820699", "aliases": ["protection by virus against host NK cell cytotoxicity", "evasion by virus of host natural killer cell response", "viral immunoevasion of host NK cell", "suppression by virus of host natural killer cell function", "evasion by virus of host NK cell killing"], "types": ["T040"], "canonical_name": "evasion by virus of host natural killer cell activity", "definition": "Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells. [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131]"}
{"concept_id": "C3820700", "aliases": [], "types": ["T040"], "canonical_name": "modulation of host NK-cell activity by virus"}
{"concept_id": "C3820701", "aliases": ["suppression by virus of host NK-cell activation"], "types": ["T043"], "canonical_name": "suppression by virus of host natural killer cell activation", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host. [GOC:bf, GOC:jl]"}
{"concept_id": "C3820702", "aliases": ["evasion by virus of host dendritic cell response", "impairing dendritic cell function by virus"], "types": ["T040"], "canonical_name": "evasion by virus of host dendritic cell activity", "definition": "Any process by which a virus avoids the effects mediated by the host organism's dendritic cells. [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118]"}
{"concept_id": "C3820703", "aliases": [], "types": ["T043"], "canonical_name": "modulation of host dendritic cell activity by virus"}
{"concept_id": "C3820704", "aliases": [], "types": ["T043"], "canonical_name": "exit of virus from host cell nucleus", "definition": "The directed movement of the viral genome or a viral particle out of the host cell nucleus. [VZ:2177]"}
{"concept_id": "C3820705", "aliases": ["nuclear pore exit of virus", "viral enome export through nuclear pore", "exit of virus from host cell nucleus through nuclear pore complex"], "types": ["T043"], "canonical_name": "exit of virus from host cell nucleus through nuclear pore", "definition": "The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore. [PMID:12921991, VZ:1953]"}
{"concept_id": "C3820706", "aliases": ["exit of virus from host cell nucleus via nuclear envelope breakdown"], "types": ["T043"], "canonical_name": "exit of virus from host cell nucleus via nuclear envelope disassembly", "definition": "The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus. [VZ:2176]"}
{"concept_id": "C3820707", "aliases": [], "types": ["T043"], "canonical_name": "viral genome ejection through host cell envelope", "definition": "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm. [GOC:ch, PMID:23385786, UniProtKB-KW:KW-1171]"}
{"concept_id": "C3820708", "aliases": [], "types": ["T043"], "canonical_name": "phage genome ejection"}
{"concept_id": "C3820709", "aliases": [], "types": ["T043"], "canonical_name": "viral genome injection through bacterial membranes"}
{"concept_id": "C3820710", "aliases": [], "types": ["T026"], "definition": "A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host. [UniProtKB-KW:KW-0842, VZ:1949]", "canonical_name": "viral occlusion body"}
{"concept_id": "C3820711", "aliases": ["actin-dependent intracellular transport of viral material towards nucleus", "actin-dependent inwards viral transport"], "types": ["T043"], "canonical_name": "actin-dependent intracellular transport of virus towards nucleus", "definition": "The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments. [UniProtKB-KW:KW-1178, VZ:991]"}
{"concept_id": "C3820712", "aliases": [], "types": ["T045"], "canonical_name": "rolling circle viral DNA replication", "definition": "A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA. [GOC:bf, GOC:jl, VZ:915, Wikipedia:Rolling_circle_replication]"}
{"concept_id": "C3820713", "aliases": ["dsDNA rolling circle replication"], "types": ["T045"], "canonical_name": "rolling circle double-stranded viral DNA replication", "definition": "A rolling circle viral DNA replication that begins with a double-stranded viral DNA genome. [GOC:bf, GOC:jl, VZ:2676]"}
{"concept_id": "C3820714", "aliases": ["ssDNA rolling circle replication"], "types": ["T045"], "canonical_name": "rolling circle single-stranded viral DNA replication", "definition": "A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome. [GOC:bf, GOC:jl, VZ:1941]"}
{"concept_id": "C3820715", "aliases": ["ssDNA rolling hairpin viral DNA replication"], "types": ["T045"], "canonical_name": "rolling hairpin viral DNA replication", "definition": "A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA. [GOC:bf, GOC:jl, VZ:2656]"}
{"concept_id": "C3820716", "aliases": ["viral bidirectional dsDNA replication"], "types": ["T045"], "canonical_name": "bidirectional double-stranded viral DNA replication", "definition": "A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions. [GOC:bf, GOC:jl, VZ:1939]"}
{"concept_id": "C3820717", "aliases": [], "types": ["T045"], "canonical_name": "viral DNA strand displacement replication", "definition": "A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA). [GOC:bf, GOC:jl, VZ:1940]"}
{"concept_id": "C3820718", "aliases": ["viral RNA-dependent DNA replication", "RNA-dependent viral DNA replication", "dsDNA replication via RNA intermediate"], "types": ["T045"], "canonical_name": "viral double stranded DNA replication via reverse transcription", "definition": "A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. [GOC:bf, GOC:jl, VZ:1938]"}
{"concept_id": "C3820720", "aliases": ["(-)ss viral RNA replication"], "types": ["T045"], "canonical_name": "negative stranded viral RNA replication", "definition": "A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA). [GOC:bf, GOC:jl, VZ:1096]"}
{"concept_id": "C3820721", "aliases": [], "types": ["T045"], "canonical_name": "positive stranded viral RNA replication", "definition": "A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA. [GOC:bf, GOC:jl, VZ:1116]"}
{"concept_id": "C3820722", "aliases": [], "types": ["T045"], "canonical_name": "ss(+) viral RNA replication"}
{"concept_id": "C3820723", "aliases": [], "types": ["T045"], "canonical_name": "double stranded viral RNA replication", "definition": "A viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA. [GOC:bf, GOC:jl, VZ:1936]"}
{"concept_id": "C3820724", "aliases": ["DNA-dependent viral DNA replication", "viral DNA-dependent DNA replication", "viral DNA replication"], "types": ["T045"], "canonical_name": "viral DNA genome replication", "definition": "The replication of a viral DNA genome. [GOC:bf, GOC:jl, VZ:915]"}
{"concept_id": "C3820725", "aliases": [], "types": ["T043"], "canonical_name": "viral RNA genome replication", "definition": "The replication of a viral RNA genome. [GOC:bf, GOC:jl]"}
{"concept_id": "C3820726", "aliases": [], "types": ["T045"], "canonical_name": "DNA-templated viral transcription", "definition": "A transcription process that uses a viral DNA as a template. [GOC:bf, GOC:jl]"}
{"concept_id": "C3820727", "aliases": [], "types": ["T045"], "canonical_name": "RNA-templated viral transcription", "definition": "A transcription process that uses viral RNA as a template. [GOC:bf, GOC:jl]"}
{"concept_id": "C3820728", "aliases": [], "types": ["T045"], "canonical_name": "negative stranded viral RNA transcription", "definition": "A viral transcription process that uses negative stranded (-) single stranded (ss) RNA as a template. [VZ:1096]"}
{"concept_id": "C3820729", "aliases": ["polyA stuttering"], "types": ["T044"], "canonical_name": "polyadenylation of viral mRNA by polymerase stuttering", "definition": "Polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail. [VZ:1916]"}
{"concept_id": "C3820730", "aliases": ["IFIT mRNA restriction evasion by virus"], "types": ["T043"], "canonical_name": "viral mRNA cap methylation", "definition": "An innate immune response evasion mechanism in which a virus methylates the 2'-O-ribose of the first or second transcribed nucleotide of its mRNAs. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs. [PMID:35215972]"}
{"concept_id": "C3820731", "aliases": ["viral primary envelope fusion with host outer nuclear membrane", "fusion of viral membrane with host outer nuclear membrane involved in nuclear egress"], "types": ["T044"], "canonical_name": "fusion of viral membrane with host outer nuclear membrane", "definition": "Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit. [PMID:23057731, UniProtKB-KW:KW-1181]"}
{"concept_id": "C3820732", "aliases": [], "types": ["T043"], "canonical_name": "microtubule-dependent intracellular transport of viral material towards cell periphery", "definition": "The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane. [UniProtKB-KW:KW-1189, VZ:1816]"}
{"concept_id": "C3820733", "aliases": ["viral budding through the ESCRT machinery"], "types": ["T043"], "canonical_name": "viral budding via host ESCRT complex", "definition": "Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process. [UniProtKB-KW:KW-1187, VZ:1536]"}
{"concept_id": "C3820734", "aliases": [], "types": ["T043"], "canonical_name": "host-assisted viral budding"}
{"concept_id": "C3820735", "aliases": ["ribosomal shunt initiation pathway"], "types": ["T043"], "canonical_name": "viral translational shunt", "definition": "A viral translation initiation mechanism where ribosomes are loaded onto viral mRNA at the 5'-cap structure and start scanning for a short distance before by-passing the large internal leader region and initiating at a downstream start site. [PMID:15827182, PMID:18195037, VZ:608]"}
{"concept_id": "C3820736", "aliases": [], "types": ["T045"], "canonical_name": "viral RNA suppression of termination"}
{"concept_id": "C3820737", "aliases": ["viral stop codon readthrough"], "types": ["T045"], "canonical_name": "viral translational readthrough", "definition": "The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons. [GOC:bf, GOC:ch, GOC:jl, PMID:10839817, VZ:859]"}
{"concept_id": "C3820738", "aliases": [], "types": ["T044"], "canonical_name": "co-receptor binding", "definition": "Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell. [GOC:bf, GOC:jl]"}
{"concept_id": "C3820739", "aliases": ["pore formation in membrane of host cell by virus"], "types": ["T038"], "canonical_name": "pore formation by virus in membrane of host cell", "definition": "The aggregation, arrangement and bonding together of a set of components by a virus to form a pore complex in a membrane of a host organism. [GOC:bf, GOC:jl, PMID:12972148, UniProtKB-KW:KW-1182]"}
{"concept_id": "C3820740", "aliases": [], "types": ["T038"], "canonical_name": "viroporin"}
{"concept_id": "C3820741", "aliases": [], "types": ["T043"], "canonical_name": "nuclear capsid assembly", "definition": "The assembly of a virus capsid that occurs in the nucleus. The assembly of large icosahedral shells for herpesviridae and adenoviridae requires structural proteins that act as chaperones for assembly. [VZ:1516]"}
{"concept_id": "C3820742", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic capsid assembly", "definition": "The assembly of a virus capsid that occurs in the cytoplasm. [VZ:1950]"}
{"concept_id": "C3820743", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic icosahedral capsid assembly", "definition": "The assembly of an icosahedral viral capsid in the cytoplasm. Often occurs by assembling around the viral genome. [VZ:1950]"}
{"concept_id": "C3820744", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic helical capsid assembly", "definition": "The assembly of a helical viral capsid in the cytoplasm. Occurs by assembling around the viral genome. [VZ:1950]"}
{"concept_id": "C3820746", "aliases": ["viral factory"], "types": ["T026"], "definition": "An intracellular compartment in a host cell which increases the efficiency of viral replication, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments. [PMID:22440839, VZ:1951]", "canonical_name": "virus factory"}
{"concept_id": "C3820747", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic viral factory", "definition": "A viral factory located in the cytoplasm of a host cell. [VZ:1951]"}
{"concept_id": "C3820748", "aliases": [], "types": ["T026"], "canonical_name": "nuclear viral factory", "definition": "A viral factory located in the nucleus of a host cell. [VZ:1951]"}
{"concept_id": "C3820749", "aliases": [], "types": ["T026"], "canonical_name": "viroplasm viral factory", "definition": "A cytoplasmic viral factory that is electron dense due to high levels of viral RNA. Produced by nucleo-cytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae and Iridoviridae, and dsRNA viruses like Reoviridae. [VZ:1951, Wikipedia:Viroplasm]"}
{"concept_id": "C3820750", "aliases": [], "types": ["T026"], "canonical_name": "spherule viral factory", "definition": "A cytoplasmic viral factory which is a 50-400nm diameter membrane invagination. Spherules can appear on several enveloped cellular components depending on the virus. [VZ:1951]"}
{"concept_id": "C3820751", "aliases": ["DMV viral factory"], "types": ["T026"], "canonical_name": "double membrane vesicle viral factory", "definition": "A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae. [PMID:22440839, VZ:1951]"}
{"concept_id": "C3820752", "aliases": [], "types": ["T026"], "canonical_name": "tube viral factory", "definition": "A cytoplasmic viral factory derived from the Golgi in which Bunyaviridae replication takes place. Tubes are membranous structures close to the assembly and budding sites, and their function may be to connect viral replication and morphogenesis inside viral factories. [VZ:1951]"}
{"concept_id": "C3820753", "aliases": ["inhibition of host TLR pathway by virus", "suppression by virus of host TLR signaling pathway"], "types": ["T044"], "canonical_name": "suppression by virus of host toll-like receptor signaling pathway", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism. [UniProtKB-KW:KW-1225]"}
{"concept_id": "C3820754", "aliases": ["inhibition of host TBK1 by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host TBK1 activity"}
{"concept_id": "C3820755", "aliases": ["inhibition of host IKBKE by virus"], "types": ["T043"], "canonical_name": "suppression by virus of host IKBKE activity"}
{"concept_id": "C3820756", "aliases": [], "types": ["T044"], "canonical_name": "ncRNA polyadenylation involved in poly(A)-dependent ncRNA catabolic process"}
{"concept_id": "C3820757", "aliases": [], "types": ["T045"], "canonical_name": "poly(A)-dependent ncRNA catabolic process"}
{"concept_id": "C3820758", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-activated signaling pathway involved in digestive tract morphogenesis"}
{"concept_id": "C3820759", "aliases": [], "types": ["T044"], "canonical_name": "cadystin transmembrane transporter ATPase activity"}
{"concept_id": "C3820760", "aliases": [], "types": ["T043"], "canonical_name": "membrane puncture-mediated penetration of viral genome into host cell"}
{"concept_id": "C3820761", "aliases": [], "types": ["T043"], "canonical_name": "viral pore-forming protein"}
{"concept_id": "C3820763", "aliases": [], "types": ["T043"], "canonical_name": "metaphase/anaphase transition of cell cycle", "definition": "The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3820764", "aliases": ["meiotic metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "metaphase/anaphase transition of meiotic cell cycle", "definition": "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3820765", "aliases": [], "types": ["T043"], "canonical_name": "cell cycle DNA replication", "definition": "The DNA-dependent DNA replication that takes place as part of the cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3820766", "aliases": ["bacterial-type cell cycle DNA replication"], "types": ["T043"], "canonical_name": "bacterial-type DNA replication", "definition": "The DNA-dependent DNA replication, exemplified by prokaryotes, that occurs as part of the cell cycle. Prokaryotic DNA replication is bi-directional and originates at a single origin of replication on the circular genome. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3820767", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of viral process", "definition": "A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. [GOC:jl]"}
{"concept_id": "C3820769", "aliases": ["downregulation of viral release from host cell", "negative regulation of viral shedding", "down regulation of viral exit", "inhibition of viral shedding", "downregulation of release of virus from host", "down regulation of viral shedding", "negative regulation of release of virus from host", "negative regulation of viral exit", "down-regulation of viral exit", "down regulation of viral release", "down regulation of viral release from host cell", "inhibition of viral release", "downregulation of viral shedding", "negative regulation of viral release from host cell", "downregulation of viral release", "down-regulation of viral shedding", "down-regulation of viral release from host cell", "inhibition of viral exit", "negative regulation by host of viral release from host cell", "negative regulation of viral release", "down-regulation of release of virus from host", "downregulation of viral exit", "down-regulation of viral release", "inhibition of release of virus from host", "down regulation of release of virus from host"], "types": ["T038"], "canonical_name": "suppression of viral release by host", "definition": "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells. [GOC:jl, PMID:18305167]"}
{"concept_id": "C3820771", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by host of viral process", "definition": "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected. [GOC:jl]"}
{"concept_id": "C3820772", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by host of viral process", "definition": "A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. [GOC:jl]"}
{"concept_id": "C3820773", "aliases": [], "types": ["T043"], "canonical_name": "trans-Golgi network to recycling endosome transport", "definition": "The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes. [GOC:lb, PMID:18779367]"}
{"concept_id": "C3820774", "aliases": ["DNA polymerase processivity factor complex location"], "types": ["T026"], "canonical_name": "DNA polymerase processivity factor complex", "definition": "A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication. [GOC:bhm, GOC:jl]"}
{"concept_id": "C3820775", "aliases": ["cytoplasmic transcription factor complex location"], "types": ["T026"], "canonical_name": "cytoplasmic transcription factor complex"}
{"concept_id": "C3820776", "aliases": ["nuclear transcription factor complex location"], "types": ["T026"], "canonical_name": "nuclear transcription factor complex"}
{"concept_id": "C3820777", "aliases": ["NarGHI complex location", "nitrate reductase A", "cytoplasmic membrane-bound quinol-nitrate oxidoreductase"], "types": ["T026"], "canonical_name": "NarGHI complex", "definition": "A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit. [GOC:bhm, PMID:11289299, PMID:12910261, PMID:17964535]"}
{"concept_id": "C3820782", "aliases": ["autophagy of nucleus", "nucleus degradation"], "types": ["T043"], "definition": "A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. [GOC:autophagy, GOC:jl, PMID:24013549]", "canonical_name": "nucleophagy"}
{"concept_id": "C3820783", "aliases": [], "types": ["T045"], "canonical_name": "G-quadruplex DNA unwinding", "definition": "The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'. [GOC:jl, GOC:se, PMID:23657261]"}
{"concept_id": "C3820784", "aliases": ["MIF production"], "types": ["T040"], "canonical_name": "macrophage migration inhibitory factor production", "definition": "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3820785", "aliases": ["OSM production"], "types": ["T040"], "canonical_name": "oncostatin M production", "definition": "The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3820786", "aliases": ["thymus and activation regulated chemokine production", "TARC production", "CCL17 production"], "types": ["T040"], "canonical_name": "chemokine (C-C motif) ligand 17 production", "definition": "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rv]"}
{"concept_id": "C3820787", "aliases": [], "types": ["T043"], "canonical_name": "Dma1-dependent checkpoint"}
{"concept_id": "C3820788", "aliases": ["response to Dma1-dependent checkpoint signalling"], "types": ["T043"], "canonical_name": "response to Dma1-dependent checkpoint signaling"}
{"concept_id": "C3820789", "aliases": ["carbohydrate fermentation"], "types": ["T044"], "canonical_name": "fermentative hydrogen production", "definition": "The fermentation of organic substances with a net release of hydrogen. [GOC:mengo_curators]"}
{"concept_id": "C3820790", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic fermentation via PFOR pathway", "definition": "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, continuing with pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species. [GOC:mengo_curators, PMID:20395274, PMID:20692761]"}
{"concept_id": "C3820791", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic fermentation via PFL pathway", "definition": "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, followed by pyruvate:formate lyase (PFL) activity. This pathway is found in facultative anaerobes such as E. coli. [GOC:mengo_curators, PMID:20395274, PMID:20692761]"}
{"concept_id": "C3820792", "aliases": ["DNA packaging complex location"], "types": ["T026"], "canonical_name": "DNA packaging complex", "definition": "A protein complex that plays a role in the process of DNA packaging. [GOC:jl]"}
{"concept_id": "C3820793", "aliases": ["Nsk1-Dlc1 complex location"], "types": ["T026"], "canonical_name": "Nsk1-Dlc1 complex", "definition": "A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation. [GOC:vw, PMID:22065639]"}
{"concept_id": "C3820794", "aliases": ["hydrogen biosynthesis via biophotolysis"], "types": ["T038"], "canonical_name": "hydrogen generation via biophotolysis", "definition": "The production of hydrogen which results from the dissociation by light of water into molecular hydrogen and oxygen. This process is observed in cyanobacteria and microalgae. [GOC:mengo_curators, PMID:20395274, PMID:20692761]"}
{"concept_id": "C3820795", "aliases": [], "types": ["T043"], "canonical_name": "mitotic G2/M transition checkpoint", "definition": "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3820796", "aliases": ["mitotic G1/S transition checkpoint"], "types": ["T043"], "canonical_name": "mitotic G1/S transition checkpoint signaling", "definition": "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3820797", "aliases": [], "types": ["T045"], "canonical_name": "mitotic telomere tethering at nuclear periphery", "definition": "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a mitotic cell cycle. [GOC:mtg_cell_cycle, PMID:25778919]"}
{"concept_id": "C3820798", "aliases": [], "types": ["T045"], "canonical_name": "meiotic telomere tethering at nuclear periphery", "definition": "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3820799", "aliases": ["poly(A)-RNA binding", "poly-A RNA binding"], "types": ["T045"], "canonical_name": "poly(A) RNA binding"}
{"concept_id": "C3820800", "aliases": [], "types": ["T044"], "canonical_name": "retroviral integrase activity", "definition": "Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism. [PMID:19091057]"}
{"concept_id": "C3820801", "aliases": ["3'-processing activity", "3' processing reaction"], "types": ["T045"], "canonical_name": "retroviral 3' processing activity", "definition": "The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls. [PMID:22580823, Reactome:R-HSA-164522]"}
{"concept_id": "C3820803", "aliases": ["viral genome integration"], "types": ["T038"], "canonical_name": "viral genome integration into host DNA", "definition": "The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses. [PMID:19091057]"}
{"concept_id": "C3820804", "aliases": ["regulation by host of viral genome reproduction"], "types": ["T043"], "canonical_name": "modulation by host of viral genome replication", "definition": "A process in which a host organism modulates the frequency, rate or extent of viral genome replication. [GOC:jl]"}
{"concept_id": "C3820805", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation by host of viral genome replication", "definition": "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication. [GOC:jl]"}
{"concept_id": "C3820806", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation by host of viral genome replication", "definition": "A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication. [GOC:jl]"}
{"concept_id": "C3820807", "aliases": ["regulation by host of viral RNA genome replication"], "types": ["T045"], "canonical_name": "modulation by host of viral RNA genome replication", "definition": "A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication. [GOC:jl]"}
{"concept_id": "C3820808", "aliases": [], "types": ["T040"], "canonical_name": "modulation by virus of host cytokine production", "definition": "Any process in which a virus modulates the frequency, rate or extent of cytokine production in its host organism. [GOC:jl]"}
{"concept_id": "C3820809", "aliases": ["positive regulation by virus of host cytokine production"], "types": ["T040"], "canonical_name": "induction by virus of host cytokine production", "definition": "The process in which a virus increases the frequency, rate or extent of cytokine production in its host organism. [GOC:jl]"}
{"concept_id": "C3820810", "aliases": [], "types": ["T043"], "canonical_name": "modulation by virus of host protein transport", "definition": "Any viral process that modulates the frequency, rate or extent of protein transport in its host organism. [GOC:jl, PMID:22334672]"}
{"concept_id": "C3820811", "aliases": [], "types": ["T026"], "canonical_name": "retroviral intasome", "definition": "A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome. [PMID:20118915]"}
{"concept_id": "C3820812", "aliases": [], "types": ["T038"], "canonical_name": "hydrogen generation via nitrogenase", "definition": "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria. [GOC:mengo_curators, PMID:22128188]"}
{"concept_id": "C3820813", "aliases": [], "types": ["T044"], "canonical_name": "D-xylose fermentation", "definition": "The anaerobic enzymatic conversion of D-xylose to ethanol, yielding energy in the form of ATP. [GOC:mengo_curators]"}
{"concept_id": "C3820814", "aliases": ["cytokinesis, actomyosin contractile ring organization"], "types": ["T043"], "canonical_name": "actomyosin contractile ring organization", "definition": "A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3820815", "aliases": ["cellular quiescence"], "types": ["T043"], "canonical_name": "cell quiescence", "definition": "A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed. [GOC:jb, GOC:mah]"}
{"concept_id": "C3820816", "aliases": [], "types": ["T043"], "canonical_name": "quiescence"}
{"concept_id": "C3820817", "aliases": [], "types": ["T026"], "canonical_name": "gut granule", "definition": "A lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. Gut granules are acidified, birefringent, autofluorescent, and contain the vacuolar H+-ATPase. They also serve as sites of cellular zinc storage. [GOC:kmv, PMID:22916203, PMID:24204312]"}
{"concept_id": "C3820818", "aliases": [], "types": ["T026"], "canonical_name": "gut granule membrane", "definition": "The membrane of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. [GOC:kmv, PMID:22916203, PMID:24204312]"}
{"concept_id": "C3820819", "aliases": [], "types": ["T026"], "canonical_name": "gut granule lumen", "definition": "The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. [GOC:kmv, PMID:22916203, PMID:24204312]"}
{"concept_id": "C3820820", "aliases": [], "types": ["T043"], "canonical_name": "cell cycle G1/S phase transition", "definition": "The cell cycle process by which a cell in G1 phase commits to S phase. [GOC:mtg_cell_cycle]"}
{"concept_id": "C3820821", "aliases": [], "types": ["T079"], "canonical_name": "meiotic interphase II", "definition": "The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge. [GOC:jl, GOC:mtg_cell_cycle]"}
{"concept_id": "C3820822", "aliases": [], "types": ["T044"], "canonical_name": "chain elongation of O-linked mannose residue", "definition": "Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules. [GOC:jl, PMID:19429925]"}
{"concept_id": "C3820823", "aliases": ["negative regulation by symbiont of auxin levels in host", "negative regulation by symbiont of IAA levels in host"], "types": ["T040"], "canonical_name": "negative regulation by symbiont of indole acetic acid levels in host", "definition": "Any process in which an organism reduces the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:ml, PMID:18056646]"}
{"concept_id": "C3820824", "aliases": ["iron acquisition by symbiont from host"], "types": ["T040"], "canonical_name": "iron acquisition from host", "definition": "The process by which a symbiont acquires iron from its host, either from heme or other iron containing molecules such as transferrin and lactoferrin. Begins with either the secretion of symbiont gene products that bind iron- or heme-containing molecules (siderophores and hemophores) from the symbiont cell into the host, or by expression of receptors that bind iron- or heme-containing molecules on the symbiont cell surface. Ends when the iron-containing compound is transported into the symbiont cell. [PMID:15487950, PMID:22865843]"}
{"concept_id": "C3820825", "aliases": [], "types": ["T040"], "canonical_name": "heme acquisition"}
{"concept_id": "C3820826", "aliases": [], "types": ["T040"], "canonical_name": "iron acquisition"}
{"concept_id": "C3820827", "aliases": [], "types": ["T040"], "canonical_name": "iron acquisition by symbiont from host heme"}
{"concept_id": "C3820828", "aliases": [], "types": ["T044"], "canonical_name": "membrane lipid peroxidation"}
{"concept_id": "C3820829", "aliases": [], "types": ["T043"], "canonical_name": "Golgi membrane viral budding during viral capsid re-envelopment"}
{"concept_id": "C3820830", "aliases": [], "types": ["T043"], "canonical_name": "viral budding from Golgi membrane during viral capsid re-envelopment"}
{"concept_id": "C3820831", "aliases": [], "types": ["T043"], "canonical_name": "virus budding from Golgi membrane during viral capsid re-envelopment"}
{"concept_id": "C3820832", "aliases": [], "types": ["T043"], "canonical_name": "virion budding"}
{"concept_id": "C3820833", "aliases": [], "types": ["T038"], "canonical_name": "viral budding from plasma membrane by viral capsid envelopment"}
{"concept_id": "C3820834", "aliases": [], "types": ["T043"], "canonical_name": "viral budding from ER membrane by viral capsid envelopment"}
{"concept_id": "C3820835", "aliases": [], "types": ["T043"], "canonical_name": "viral budding from nuclear membrane by viral capsid envelopment"}
{"concept_id": "C3820836", "aliases": [], "types": ["T043"], "canonical_name": "viral budding from inner nuclear membrane by viral capsid envelopment"}
{"concept_id": "C3820837", "aliases": [], "types": ["T044"], "canonical_name": "cadystin metabolic process"}
{"concept_id": "C3820838", "aliases": [], "types": ["T044"], "canonical_name": "cadystin metabolism"}
{"concept_id": "C3820840", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin transferase regulator"}
{"concept_id": "C3820841", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin-protein transferase regulator"}
{"concept_id": "C3820842", "aliases": [], "types": ["T044"], "canonical_name": "activation of ubiquitin transferase activity"}
{"concept_id": "C3820843", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of ubiquitin transferase activity"}
{"concept_id": "C3820844", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin transferase activator"}
{"concept_id": "C3820845", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ubiquitin transferase activity"}
{"concept_id": "C3820846", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin transferase inhibitor"}
{"concept_id": "C3820847", "aliases": [], "types": ["T043"], "canonical_name": "cell cycle switching, mitosis to meiosis"}
{"concept_id": "C3820848", "aliases": [], "types": ["T043"], "canonical_name": "germline cell cycle switching, mitosis to meiosis"}
{"concept_id": "C3820849", "aliases": [], "types": ["T044"], "canonical_name": "ali-esterase activity"}
{"concept_id": "C3820850", "aliases": [], "types": ["T044"], "canonical_name": "alpha-carboxylesterase activity"}
{"concept_id": "C3820851", "aliases": [], "types": ["T044"], "canonical_name": "nonspecific carboxylesterase activity"}
{"concept_id": "C3820852", "aliases": [], "types": ["T044"], "canonical_name": "serine esterase activity"}
{"concept_id": "C3820853", "aliases": [], "types": ["T044"], "canonical_name": "glucose 6-phosphate:inorganic phosphate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out). [GOC:dph, PMID:18337460]"}
{"concept_id": "C3820854", "aliases": [], "types": ["T043"], "canonical_name": "interleukin-34-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-34 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, PMID:18467591]"}
{"concept_id": "C3820855", "aliases": [], "types": ["T043"], "canonical_name": "myeloid cell development", "definition": "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C3820856", "aliases": [], "types": ["T043"], "canonical_name": "monocyte proliferation", "definition": "The expansion of a monocyte population by cell division. [GOC:dph, PMID:18467591]"}
{"concept_id": "C3820857", "aliases": [], "types": ["T043"], "canonical_name": "macrophage proliferation", "definition": "The expansion of a macrophage population by cell division. [GOC:dph, PMID:12614284, PMID:19466391]"}
{"concept_id": "C3820858", "aliases": [], "types": ["T043"], "canonical_name": "microglial cell proliferation", "definition": "The expansion of a microglial cell population by cell division. [GOC:dph, PMID:17344397]"}
{"concept_id": "C3820859", "aliases": [], "types": ["T043"], "canonical_name": "macrophage homeostasis", "definition": "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:dph, PMID:21727904]"}
{"concept_id": "C3820860", "aliases": [], "types": ["T043"], "canonical_name": "Langerhans cell differentiation", "definition": "The process in which a precursor cell type acquires the specialized features of a Langerhans cell. [GOC:dph, PMID:22729249]"}
{"concept_id": "C3820861", "aliases": [], "types": ["T043"], "canonical_name": "hepatic stellate cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell. [GOC:dph, PMID:9407545]"}
{"concept_id": "C3820862", "aliases": [], "types": ["T044"], "canonical_name": "1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity", "definition": "Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA. [GOC:dph]"}
{"concept_id": "C3820863", "aliases": ["cilium resorption"], "types": ["T043"], "canonical_name": "cilium disassembly", "definition": "A cellular process that results in the breakdown of a cilium. [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441]"}
{"concept_id": "C3820864", "aliases": [], "types": ["T042"], "canonical_name": "central canal development", "definition": "The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord. [GOC:cvs, GOC:dph, PMID:23409159]"}
{"concept_id": "C3820865", "aliases": [], "types": ["T042"], "canonical_name": "hindgut development", "definition": "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. [GOC:dph]"}
{"concept_id": "C3820866", "aliases": [], "types": ["T043"], "canonical_name": "acetylcholine secretion", "definition": "The regulated release of acetylcholine by a cell. [GOC:dph]"}
{"concept_id": "C3820867", "aliases": [], "types": ["T043"], "canonical_name": "dopamine secretion, neurotransmission", "definition": "The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820868", "aliases": [], "types": ["T043"], "canonical_name": "aspartate secretion", "definition": "The regulated release of aspartate by a cell. [GOC:dph]"}
{"concept_id": "C3820869", "aliases": ["adrenaline secretion, neurotransmission"], "types": ["T043"], "canonical_name": "epinephrine secretion, neurotransmission", "definition": "The regulated release of epinephrine by a cell in which the epinephrine acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820870", "aliases": [], "types": ["T043"], "canonical_name": "aspartate secretion, neurotransmission", "definition": "The regulated release of aspartate by a cell in which the aspartate acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820871", "aliases": [], "types": ["T043"], "canonical_name": "primary amine secretion", "definition": "The regulated release of a primary amine by a cell. [GOC:dph]"}
{"concept_id": "C3820872", "aliases": [], "types": ["T043"], "canonical_name": "primary amine secretion, neurotransmission", "definition": "The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820873", "aliases": ["noradrenaline secretion, neurotransmission"], "types": ["T043"], "canonical_name": "norepinephrine secretion, neurotransmission", "definition": "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820874", "aliases": [], "types": ["T043"], "canonical_name": "gamma-aminobutyric acid secretion, neurotransmission", "definition": "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820875", "aliases": [], "types": ["T043"], "canonical_name": "glutamate secretion, neurotransmission", "definition": "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820876", "aliases": [], "types": ["T043"], "canonical_name": "glycine secretion", "definition": "The controlled release of glycine by a cell. [GOC:dph]"}
{"concept_id": "C3820877", "aliases": [], "types": ["T043"], "canonical_name": "glycine secretion, neurotransmission", "definition": "The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820878", "aliases": [], "types": ["T043"], "canonical_name": "histamine secretion, neurotransmission", "definition": "The controlled release of histamine by a cell, in which the histamine acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820879", "aliases": [], "types": ["T043"], "canonical_name": "octopamine secretion", "definition": "The controlled release of octopamine by a cell. [GOC:dph]"}
{"concept_id": "C3820880", "aliases": [], "types": ["T043"], "canonical_name": "octopamine secretion, neurotransmission", "definition": "The controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820881", "aliases": [], "types": ["T043"], "canonical_name": "rhabdomere morphogenesis", "definition": "The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments. [GOC:dph, PMID:22113834]"}
{"concept_id": "C3820882", "aliases": [], "types": ["T044"], "canonical_name": "3-demethylubiquinol-n 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n. [EC:2.1.1.64, GOC:dph]"}
{"concept_id": "C3820883", "aliases": [], "types": ["T044"], "canonical_name": "3-demethylubiquinol-6 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-6 = S-adenosyl-L-homocysteine + ubiquinol-6. [GOC:dph]"}
{"concept_id": "C3820884", "aliases": [], "types": ["T043"], "canonical_name": "peptide secretion, neurotransmission", "definition": "The controlled release of a peptide from a cell in which the peptide acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820885", "aliases": [], "types": ["T043"], "canonical_name": "tyramine secretion", "definition": "The regulated release of a tyramine by a cell. [GOC:dph]"}
{"concept_id": "C3820886", "aliases": [], "types": ["T043"], "canonical_name": "tyramine secretion, neurotransmission", "definition": "The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820887", "aliases": [], "types": ["T044"], "canonical_name": "glycogen synthase activity, transferring glucose-1-phosphate", "definition": "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate. [GOC:dph, PMID:21356517]"}
{"concept_id": "C3820888", "aliases": ["ganglia development"], "types": ["T042"], "canonical_name": "ganglion development", "definition": "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C3820890", "aliases": [], "types": ["T042"], "canonical_name": "gangliogenesis"}
{"concept_id": "C3820891", "aliases": ["sympathetic ganglia development"], "types": ["T042"], "canonical_name": "sympathetic ganglion development", "definition": "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. [GOC:BHF, GOC:rl]"}
{"concept_id": "C3820893", "aliases": ["cranial ganglia development"], "types": ["T042"], "canonical_name": "cranial ganglion development", "definition": "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C3820895", "aliases": ["trigeminal ganglia development"], "types": ["T042"], "canonical_name": "trigeminal ganglion development", "definition": "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. [GOC:dph]"}
{"concept_id": "C3820897", "aliases": ["ganglia morphogenesis"], "types": ["T042"], "canonical_name": "ganglion morphogenesis", "definition": "The process in which the anatomical structures of ganglion are generated and organized. [GOC:dph]"}
{"concept_id": "C3820899", "aliases": ["ganglia maturation"], "types": ["T042"], "canonical_name": "ganglion maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. [GOC:dph]"}
{"concept_id": "C3820901", "aliases": ["ganglia formation"], "types": ["T042"], "canonical_name": "ganglion formation", "definition": "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. [GOC:dph]"}
{"concept_id": "C3820902", "aliases": ["ganglia structural organization"], "types": ["T040"], "canonical_name": "ganglion structural organization", "definition": "The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure. [GOC:dph]"}
{"concept_id": "C3820904", "aliases": ["trigeminal ganglia morphogenesis"], "types": ["T042"], "canonical_name": "trigeminal ganglion morphogenesis", "definition": "The process in which the anatomical structure of a trigeminal ganglion is generated and organized. [GOC:dph]"}
{"concept_id": "C3820906", "aliases": ["trigeminal ganglia maturation"], "types": ["T042"], "canonical_name": "trigeminal ganglion maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. [GOC:dph]"}
{"concept_id": "C3820908", "aliases": ["cranial ganglia maturation"], "types": ["T042"], "canonical_name": "cranial ganglion maturation", "definition": "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. [GOC:dph]"}
{"concept_id": "C3820911", "aliases": ["cranial ganglia formation"], "types": ["T042"], "canonical_name": "cranial ganglion formation", "definition": "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. [GOC:dph]"}
{"concept_id": "C3820913", "aliases": ["trigeminal ganglia formation"], "types": ["T042"], "canonical_name": "trigeminal ganglion formation", "definition": "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. [GOC:dph]"}
{"concept_id": "C3820915", "aliases": ["cranial ganglia structural organization"], "types": ["T042"], "canonical_name": "cranial ganglion structural organization", "definition": "The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure. [GOC:dph]"}
{"concept_id": "C3820917", "aliases": ["trigeminal ganglia organization"], "types": ["T042"], "canonical_name": "trigeminal ganglion structural organization", "definition": "The process that contributes to creating the structural organization of the trigeminal ganglion This process pertains to the physical shaping of a rudimentary structure. [GOC:dph]"}
{"concept_id": "C3820918", "aliases": [], "types": ["T043"], "canonical_name": "axon development", "definition": "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation). [GOC:dph, GOC:pg, GOC:pr]"}
{"concept_id": "C3820919", "aliases": [], "types": ["T044"], "canonical_name": "dAMP phosphorylation", "definition": "The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP. [GOC:dph, PMID:23416111]"}
{"concept_id": "C3820920", "aliases": [], "types": ["T044"], "canonical_name": "CMP phosphorylation", "definition": "The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP. [GOC:dph, PMID:23416111]"}
{"concept_id": "C3820921", "aliases": [], "types": ["T044"], "canonical_name": "dCMP phosphorylation", "definition": "The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP. [GOC:dph, PMID:23416111]"}
{"concept_id": "C3820922", "aliases": [], "types": ["T044"], "canonical_name": "GDP phosphorylation", "definition": "The process of introducing a phosphate group into GDP, guanosine diphosphate, to produce GTP. [GOC:dph, PMID:23416111]"}
{"concept_id": "C3820923", "aliases": [], "types": ["T044"], "canonical_name": "UDP phosphorylation", "definition": "The process of introducing a phosphate group into UDP, uridine diphosphate, to produce UTP. [GOC:dph, PMID:23416111]"}
{"concept_id": "C3820924", "aliases": [], "types": ["T044"], "canonical_name": "dCDP phosphorylation", "definition": "The process of introducing a phosphate group into dCDP to produce a dCTP. [GOC:dph, PMID:23416111]"}
{"concept_id": "C3820925", "aliases": [], "types": ["T044"], "canonical_name": "TDP phosphorylation", "definition": "The process of introducing a phosphate group into TDP to produce a TTP. [GOC:dph, PMID:23416111]"}
{"concept_id": "C3820926", "aliases": [], "types": ["T043"], "canonical_name": "actin filament bundle organization", "definition": "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. [GOC:dph]"}
{"concept_id": "C3820927", "aliases": [], "types": ["T043"], "canonical_name": "actin filament cable organization"}
{"concept_id": "C3820928", "aliases": [], "types": ["T043"], "canonical_name": "actin filament bundle retrograde transport", "definition": "A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell. [GOC:dph]"}
{"concept_id": "C3820929", "aliases": [], "types": ["T043"], "canonical_name": "actin filament cable retrograde transport"}
{"concept_id": "C3820930", "aliases": ["ASAP complex location"], "types": ["T026"], "canonical_name": "ASAP complex", "definition": "A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1. [GOC:dph, PMID:12665594, PMID:16314458, PMID:22388736]"}
{"concept_id": "C3820931", "aliases": [], "types": ["T044"], "canonical_name": "cyclin-dependent protein serine/threonine kinase activator activity", "definition": "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810]"}
{"concept_id": "C3820932", "aliases": ["acyl-CoA ceramide synthase complex location"], "types": ["T026"], "canonical_name": "acyl-CoA ceramide synthase complex", "definition": "A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1. [GOC:dph, PMID:15692566]"}
{"concept_id": "C3820933", "aliases": [], "types": ["T044"], "canonical_name": "generation of L-type calcium current"}
{"concept_id": "C3820934", "aliases": [], "types": ["T044"], "canonical_name": "Lys63-specific deubiquitinase activity", "definition": "Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein. [GOC:dph, GOC:pg, PMID:18313383]"}
{"concept_id": "C3820935", "aliases": [], "types": ["T044"], "canonical_name": "N-acyl homoserine lactone synthase activity", "definition": "Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone. [GOC:dph]"}
{"concept_id": "C3820936", "aliases": [], "types": ["T044"], "canonical_name": "autoinducer-1 synthase"}
{"concept_id": "C3820937", "aliases": [], "types": ["T043"], "canonical_name": "colon epithelial cell migration", "definition": "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism. [GOC:dph]"}
{"concept_id": "C3820938", "aliases": [], "types": ["T043"], "canonical_name": "corneal epithelial cell migration", "definition": "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism. [GOC:dph]"}
{"concept_id": "C3820939", "aliases": [], "types": ["T043"], "canonical_name": "intestinal epithelial cell migration", "definition": "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism. [GOC:dph]"}
{"concept_id": "C3820940", "aliases": [], "types": ["T043"], "canonical_name": "colon epithelial cell chemotaxis", "definition": "The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]"}
{"concept_id": "C3820941", "aliases": ["orexin secretion"], "types": ["T043"], "canonical_name": "hypocretin secretion", "definition": "The controlled release of hypocretin from a cell or a tissue. [GOC:dph]"}
{"concept_id": "C3820942", "aliases": ["orexin secretion, neurotransmission"], "types": ["T043"], "canonical_name": "hypocretin secretion, neurotransmission", "definition": "The controlled release of a peptide from a cell or a tissue in which the peptide acts as a neurotransmitter. [GOC:dph]"}
{"concept_id": "C3820943", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transcription by transcription factor localization", "definition": "Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor. [GOC:dph]"}
{"concept_id": "C3820944", "aliases": ["transfer RNA gene-mediated gene silencing", "tgm silencing", "tRNA gene-mediated chromatin silencing", "tRNA gene-mediated gene silencing", "transfer RNA gene-mediated chromatin silencing"], "types": ["T045"], "canonical_name": "transfer RNA gene-mediated silencing", "definition": "The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes. [GOC:dph, PMID:23707796]"}
{"concept_id": "C3820945", "aliases": [], "types": ["T043"], "canonical_name": "calcium activated phospholipid scrambling", "definition": "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. [GOC:krc, PMID:23532839]"}
{"concept_id": "C3820946", "aliases": [], "types": ["T043"], "canonical_name": "calcium activated phosphatidylserine scrambling", "definition": "The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. [GOC:krc, PMID:23532839]"}
{"concept_id": "C3820947", "aliases": [], "types": ["T043"], "canonical_name": "calcium activated phosphatidylcholine scrambling", "definition": "The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. [GOC:krc, PMID:23532839]"}
{"concept_id": "C3820948", "aliases": [], "types": ["T043"], "canonical_name": "calcium activated galactosylceramide scrambling", "definition": "The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. [GOC:krc, PMID:23532839]"}
{"concept_id": "C3820949", "aliases": [], "types": ["T043"], "canonical_name": "phosphatidylserine exposure on osteoblast involved in bone mineralization", "definition": "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of osteoblasts, and contributes to bone mineralization. [GOC:krc, PMID:22936354]"}
{"concept_id": "C3820950", "aliases": [], "types": ["T044"], "canonical_name": "sulfoquinovose isomerase activity", "definition": "Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose. [GOC:dph, PMID:24463506]"}
{"concept_id": "C3820951", "aliases": [], "types": ["T044"], "canonical_name": "6-deoxy-6-sulfofructose kinase activity", "definition": "Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP. [PMID:24463506]"}
{"concept_id": "C3820952", "aliases": [], "types": ["T044"], "canonical_name": "6-deoxy-6-sulfofructose-1-phosphate aldolase activity", "definition": "Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate. [PMID:24463506]"}
{"concept_id": "C3820953", "aliases": [], "types": ["T044"], "canonical_name": "3-sulfolactaldehyde reductase activity", "definition": "Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+. [EC:1.1.1.373, GOC:dph, PMID:24463506]"}
{"concept_id": "C3820955", "aliases": [], "types": ["T044"], "canonical_name": "molybdopterin adenylyltransferase activity", "definition": "Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin. [EC:2.7.7.75, GOC:dph]"}
{"concept_id": "C3820956", "aliases": [], "types": ["T044"], "canonical_name": "molybdopterin molybdotransferase activity", "definition": "Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP. [EC:2.10.1.1, GOC:dph]"}
{"concept_id": "C3820957", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum cofactor cytidylyltransferase activity", "definition": "Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor. [EC:2.7.7.76, GOC:dph]"}
{"concept_id": "C3820958", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum cofactor guanylyltransferase activity", "definition": "Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor. [EC:2.7.7.77, GOC:dph]"}
{"concept_id": "C3820959", "aliases": [], "types": ["T044"], "canonical_name": "molybdopterin-synthase sulfurtransferase activity", "definition": "Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase. [EC:2.8.1.11, GOC:dph, PMID:18154309, PMID:22370186]"}
{"concept_id": "C3820960", "aliases": [], "types": ["T044"], "canonical_name": "molybdopterin-synthase adenylyltransferase activity", "definition": "Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP. [EC:2.7.7.80, GOC:dph, PMID:18154309, PMID:22370186]"}
{"concept_id": "C3820961", "aliases": [], "types": ["T044"], "canonical_name": "N-terminal protein amino acid propionylation", "definition": "The propionylation of the N-terminal amino acid of proteins. [GOC:dph, PMID:17267393, PMID:23043182]"}
{"concept_id": "C3820962", "aliases": ["N-terminal propionyltransferase activity"], "types": ["T044"], "canonical_name": "peptide alpha-N-propionyltransferase activity", "definition": "Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein. [GOC:dph, PMID:23043182]"}
{"concept_id": "C3820963", "aliases": [], "types": ["T044"], "canonical_name": "nuclear import signal receptor activity", "definition": "Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]"}
{"concept_id": "C3820964", "aliases": ["glycerol metabolism to glycerone phosphate", "glycerol metabolism to dihydroxyacetone phosphate", "glycerol metabolism to DHAP", "glycerol to DHAP metabolic process", "glycerol to dihydroxyacetone phosphate metabolic process"], "types": ["T044"], "canonical_name": "glycerol to glycerone phosphate metabolic process", "definition": "The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate. [GOC:dph, ISBN:0201090910]"}
{"concept_id": "C3820965", "aliases": ["mannose metabolism to fructose-6-phosphate"], "types": ["T044"], "canonical_name": "mannose to fructose-6-phosphate metabolic process", "definition": "The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate. [GOC:dph, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C3820966", "aliases": [], "types": ["T044"], "canonical_name": "galactose to glucose-1-phosphate metabolic process", "definition": "The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate. [GOC:dph, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C3820967", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic process from glycerol", "definition": "The glycolytic process in which glycerol is catabolized to pyruvate generating ATP and NADH. [GOC:dph, ISBN:0201090910]"}
{"concept_id": "C3820968", "aliases": ["microRNA gene transcription", "pri-miRNA transcription by RNA polymerase II", "primary miRNA gene transcription", "pri-miRNA transcription from RNA polymerase II promoter", "miRNA gene transcription"], "types": ["T045"], "canonical_name": "miRNA transcription", "definition": "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation. [GOC:dph, GOC:kmv, PMID:18778799]"}
{"concept_id": "C3820969", "aliases": ["glycolysis through fructose-6-phosphate"], "types": ["T044"], "canonical_name": "glycolytic process through fructose-6-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH. [GOC:dph, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C3820970", "aliases": ["glycolysis from fructose through fructose-6-phosphate"], "types": ["T044"], "canonical_name": "glycolytic process from fructose through fructose-6-phosphate", "definition": "The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate. [GOC:dph, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C3820971", "aliases": ["MICOS complex location", "MINOS complex location", "Fcj1 complex location", "MINOS complex", "MitOS complex", "Fcj1 complex", "MitOS complex location", "mitochondrial contact site and cristae organizing system"], "types": ["T026"], "canonical_name": "MICOS complex", "definition": "Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60. [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]"}
{"concept_id": "C3820973", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic process from mannose through fructose-6-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH. [GOC:dph, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C3820974", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic process through glucose-6-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP. [GOC:dph, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C3820975", "aliases": [], "types": ["T044"], "canonical_name": "canonical glycolysis", "definition": "The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP. [GOC:dph, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C3820976", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic process through glucose-1-phosphate", "definition": "The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP. [GOC:dph, ISBN:0201090910]"}
{"concept_id": "C3820977", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic process from galactose", "definition": "The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP. [GOC:dph, ISBN:0201090910]"}
{"concept_id": "C3820978", "aliases": [], "types": ["T044"], "canonical_name": "fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. [GOC:dph, ISBN:0201090910]"}
{"concept_id": "C3820979", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic process through fructose-1-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH. [GOC:dph, ISBN:0201090910]"}
{"concept_id": "C3820980", "aliases": [], "types": ["T042"], "canonical_name": "pharyngeal arch artery morphogenesis", "definition": "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. [GOC:BHF, GOC:dph, PMID:20122914]"}
{"concept_id": "C3820981", "aliases": [], "types": ["T042"], "canonical_name": "aortic arch artery morphogenesis"}
{"concept_id": "C3820982", "aliases": ["S-methylmethionine homocysteine transmethylase activity", "methylmethionine:homocysteine methyltransferase activity"], "types": ["T044"], "canonical_name": "S-methylmethionine-homocysteine S-methyltransferase activity", "definition": "Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+. [EC:2.1.1.10, GOC:BHF, GOC:dph]"}
{"concept_id": "C3820983", "aliases": ["H3-K27me3 modified histone binding"], "types": ["T044"], "canonical_name": "H3K27me3 modified histone binding", "definition": "Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation. [GOC:dph, PMID:23948251]"}
{"concept_id": "C3820984", "aliases": ["RNA polymerase II sequence-specific DNA-binding transcription factor binding", "RNA polymerase II sequence-specific DNA binding transcription factor binding"], "types": ["T045"], "canonical_name": "RNA polymerase II-specific DNA-binding transcription factor binding", "definition": "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]"}
{"concept_id": "C3820985", "aliases": [], "types": ["T044"], "canonical_name": "HECT E3"}
{"concept_id": "C3820986", "aliases": [], "types": ["T043"], "canonical_name": "TNF-induced necroptosis"}
{"concept_id": "C3820987", "aliases": [], "types": ["T044"], "canonical_name": "calcitriol signaling pathway"}
{"concept_id": "C3820989", "aliases": [], "types": ["T026"], "canonical_name": "extracellular proteinaceous gel"}
{"concept_id": "C3820990", "aliases": [], "types": ["T045"], "canonical_name": "nuclear poly(A)-dependent snoRNA catabolic process"}
{"concept_id": "C3820991", "aliases": [], "types": ["T045"], "canonical_name": "nuclear poly(A)-dependent tRNA catabolic process"}
{"concept_id": "C3820992", "aliases": [], "types": ["T045"], "canonical_name": "nuclear poly(A)-dependent CUT catabolic process"}
{"concept_id": "C3820993", "aliases": [], "types": ["T045"], "canonical_name": "nuclear poly(A)-dependent mRNA catabolic process"}
{"concept_id": "C3820994", "aliases": [], "types": ["T045"], "canonical_name": "nuclear poly(A)-dependent ncRNA catabolic process"}
{"concept_id": "C3820995", "aliases": [], "types": ["T045"], "canonical_name": "poly(A)-dependent mRNA catabolic process"}
{"concept_id": "C3820996", "aliases": [], "types": ["T045"], "canonical_name": "poly(A)-dependent snoRNA 3'-end processing"}
{"concept_id": "C3820997", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to darkness"}
{"concept_id": "C3820998", "aliases": [], "types": ["T043"], "canonical_name": "regulation of bacterial-type flagellar cell motility by regulation of motor speed"}
{"concept_id": "C3820999", "aliases": [], "types": ["T044"], "canonical_name": "cadystin transporter activity"}
{"concept_id": "C3821001", "aliases": [], "types": ["T043"], "canonical_name": "cadystin transport"}
{"concept_id": "C3821002", "aliases": [], "types": ["T043"], "canonical_name": "cadystin transmembrane transport"}
{"concept_id": "C3821003", "aliases": [], "types": ["T043"], "canonical_name": "cadystin import into vacuole"}
{"concept_id": "C3821004", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation"}
{"concept_id": "C3821005", "aliases": [], "types": ["T043"], "canonical_name": "viral entry into host cell via caveolae-mediated endocytosis followed by endosome membrane"}
{"concept_id": "C3821006", "aliases": [], "types": ["T043"], "canonical_name": "viral entry into host cell via caveolin-mediated endocytosis"}
{"concept_id": "C3821007", "aliases": [], "types": ["T045"], "canonical_name": "IRES-dependent viral translational initiation", "definition": "Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation. [GOC:bf, GOC:jl, PMID:19632368, VZ:867]"}
{"concept_id": "C3821008", "aliases": ["ribosomal frameshifting involved in viral translation"], "types": ["T045"], "canonical_name": "viral translational frameshifting", "definition": "A process which occurs during viral translation, which involves a translational recoding mechanism called programmed ribosomal frameshifting. This causes the ribosome to alter its reading of the mRNA to an a different open reading frame to produce alternate viral proteins. [GOC:bf, GOC:ch, GOC:jl, PMID:24825891, PMID:8852897, VZ:860]"}
{"concept_id": "C3821009", "aliases": [], "types": ["T038"], "canonical_name": "ribosomal skipping", "definition": "A translation process in which a specific viral peptide prevents the ribosome from covalently linking a new inserted amino acid, and lets it continue translation, thereby cleaving the nascent protein while allowing translation to continue. [GOC:bf, GOC:ch, GOC:jl, VZ:914]"}
{"concept_id": "C3821010", "aliases": ["termination reinitiation involved in viral translation", "viral translation involving termination re-initiation", "viral translation involving translational stop-start", "viral translation involving termination-reinitiation"], "types": ["T038"], "canonical_name": "viral translational termination-reinitiation", "definition": "A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF. [GOC:bf, GOC:ch, GOC:jl, PMID:18631147, PMID:18824510, VZ:858]"}
{"concept_id": "C3821011", "aliases": ["cap snatching involved in viral mRNA transcription"], "types": ["T038"], "canonical_name": "cap snatching", "definition": "A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs. [GOC:bf, GOC:jl, VZ:839]"}
{"concept_id": "C3821012", "aliases": ["RNA editing involved in viral mRNA transcription"], "types": ["T045"], "canonical_name": "viral RNA editing", "definition": "The process by which bases in viral mRNA are chemically altered during viral transcription. This is usually the incorporation of 1 - 6 additional nucleotides, which shifts the reading frame, allowing the generation of different protein products or through a specific nucleotide change that eliminates the termination codon. [PMID:1629949, VZ:857]"}
{"concept_id": "C3821013", "aliases": ["regulation by virus of host immune system process"], "types": ["T043"], "canonical_name": "modulation by virus of host immune response", "definition": "The process in which a virus effects a change in the host immune response. [GOC:bf, GOC:jl]"}
{"concept_id": "C3821014", "aliases": [], "types": ["T043"], "canonical_name": "viral egress"}
{"concept_id": "C3821015", "aliases": [], "types": ["T043"], "canonical_name": "sinus node cardiac muscle cell action potential"}
{"concept_id": "C3821016", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential"}
{"concept_id": "C3821017", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential"}
{"concept_id": "C3821018", "aliases": [], "types": ["T045"], "canonical_name": "down-regulation of transcription from RNA polymerase II promoter during the G2/M transition of the mitotic cell cycle"}
{"concept_id": "C3821019", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle"}
{"concept_id": "C3821020", "aliases": [], "types": ["T043"], "canonical_name": "ceramide 1-phosphate signaling pathway"}
{"concept_id": "C3821021", "aliases": [], "types": ["T043"], "canonical_name": "sphingosine signaling pathway"}
{"concept_id": "C3821022", "aliases": [], "types": ["T040"], "canonical_name": "response to low humidity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of low humidity stimulus, reduced moisture in the atmosphere. [GOC:tb]"}
{"concept_id": "C3821023", "aliases": [], "types": ["T040"], "canonical_name": "response to nitrate starvation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nitrate. [GOC:tair_curators]"}
{"concept_id": "C3821024", "aliases": [], "types": ["T040"], "canonical_name": "response to carbon starvation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source. [GOC:tair_curators, PMID:18245858]"}
{"concept_id": "C3821025", "aliases": [], "types": ["T040"], "canonical_name": "response to molybdenum starvation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of molybdenum. [GOC:tair_curators]"}
{"concept_id": "C3821026", "aliases": [], "types": ["T040"], "canonical_name": "response to manganese starvation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of manganese. [GOC:tair_curators]"}
{"concept_id": "C3821027", "aliases": [], "types": ["T026"], "canonical_name": "unicellular trichome apex", "definition": "A cell projection part that is the apical most portion of a unicellular trichome. [GOC:PO_curators, PO:0025537]"}
{"concept_id": "C3821028", "aliases": [], "types": ["T026"], "canonical_name": "unicellular trichome tip", "definition": "A cell projection part that is the apical most portion of a unicellular trichome apex. [GOC:PO_curators]"}
{"concept_id": "C3821029", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine-translocating ATPase activity"}
{"concept_id": "C3821030", "aliases": ["phosphatidylethanolamine-translocating ATPase activity", "phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)"], "types": ["T044"], "canonical_name": "phosphatidylethanolamine flippase activity", "definition": "Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [GOC:ab, PMID:16452632, PMID:20043909, RHEA:36440]"}
{"concept_id": "C3821031", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylserine-translocating ATPase activity"}
{"concept_id": "C3821032", "aliases": [], "types": ["T043"], "canonical_name": "establishment of endothelial intestinal barrier", "definition": "The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:krc, PMID:22155109]"}
{"concept_id": "C3821033", "aliases": [], "types": ["T042"], "canonical_name": "plant epidermis development", "definition": "The process whose specific outcome is the progression of the plant epidermis over time, from its formation to the mature structure. [GOC:tb]"}
{"concept_id": "C3821034", "aliases": [], "types": ["T038"], "canonical_name": "regulation of membrane permeability", "definition": "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. [GOC:kmv, PMID:22677064]"}
{"concept_id": "C3821035", "aliases": [], "types": ["T044"], "canonical_name": "2-(3-amino-3-carboxypropyl)histidine synthase activity", "definition": "Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]. [GOC:pde, PMID:15485916]"}
{"concept_id": "C3821036", "aliases": [], "types": ["T043"], "canonical_name": "nuclear migration during mitotic telophase", "definition": "The dynein-driven microtubule based nuclear migration, whereby daughter nuclei are positioned away from the cell division site prior to cytokinesis. [GOC:vw, PMID:23087209]"}
{"concept_id": "C3821037", "aliases": [], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in). [GOC:am, PMID:10913119]"}
{"concept_id": "C3821038", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-sugar phosphotransferase activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:am]"}
{"concept_id": "C3821039", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-glucose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:am]"}
{"concept_id": "C3821040", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-mannitol phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. [GOC:am]"}
{"concept_id": "C3821041", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in). [GOC:am, PMID:10913119]"}
{"concept_id": "C3821042", "aliases": [], "types": ["T040"], "canonical_name": "reproductive shoot system development", "definition": "The process whose specific outcome is the progression of a reproductive shoot system over time, from its formation to the mature structure. [GOC:pj]"}
{"concept_id": "C3821043", "aliases": ["nuclear transcriptional repressor complex location"], "types": ["T026"], "canonical_name": "nuclear transcriptional repressor complex"}
{"concept_id": "C3821044", "aliases": ["cytoplasmic transcriptional repressor complex location"], "types": ["T026"], "canonical_name": "cytoplasmic transcriptional repressor complex"}
{"concept_id": "C3821045", "aliases": ["RNA polymerase I transcription repressor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase I transcription repressor complex", "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter. [GOC:tb]"}
{"concept_id": "C3821046", "aliases": ["RNA polymerase II transcription repressor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase II transcription repressor complex", "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter. [GOC:tb]"}
{"concept_id": "C3821047", "aliases": ["RNA polymerase III transcription repressor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase III transcription repressor complex", "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter. [GOC:tb]"}
{"concept_id": "C3821048", "aliases": ["RNA polymerase IV transcription repressor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase IV transcription repressor complex", "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter. [GOC:tb]"}
{"concept_id": "C3821049", "aliases": ["RNA polymerase V transcription repressor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase V transcription repressor complex", "definition": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter. [GOC:tb]"}
{"concept_id": "C3821050", "aliases": ["RNA polymerase II transcription factor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase II transcription factor complex"}
{"concept_id": "C3821051", "aliases": ["RNA polymerase III transcription factor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase III transcription factor complex"}
{"concept_id": "C3821052", "aliases": ["RNA polymerase IV transcription factor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase IV transcription factor complex"}
{"concept_id": "C3821053", "aliases": ["RNA polymerase V transcription factor complex location"], "types": ["T026"], "canonical_name": "RNA polymerase V transcription factor complex"}
{"concept_id": "C3821055", "aliases": [], "types": ["T044"], "canonical_name": "phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands", "definition": "Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand. [GOC:pde, GOC:rb, PMID:11238902]"}
{"concept_id": "C3821056", "aliases": [], "types": ["T044"], "canonical_name": "glycolysis from storage polysaccharide through glucose-1-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH. [GOC:dph, GOC:glycolysis]"}
{"concept_id": "C3821057", "aliases": ["response to antihelmintic", "response to nematocide"], "types": ["T043"], "canonical_name": "response to nematicide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes. [GOC:kvm, PMID:22301316]"}
{"concept_id": "C3821058", "aliases": [], "types": ["T026"], "canonical_name": "necrosome"}
{"concept_id": "C3821059", "aliases": ["TNFR1 complex II location"], "types": ["T026"], "canonical_name": "TNFR1 complex II"}
{"concept_id": "C3821060", "aliases": [], "types": ["T026"], "canonical_name": "Tnfr1-CII"}
{"concept_id": "C3821061", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial outer membrane permeabilization during apoptotic cell death"}
{"concept_id": "C3821062", "aliases": [], "types": ["T043"], "canonical_name": "motor neuron migration", "definition": "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. [CL:0000100, GOC:yaf, PMID:20711475]"}
{"concept_id": "C3821063", "aliases": [], "types": ["T043"], "canonical_name": "spinal cord motor neuron migration", "definition": "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. [CL:0011001, GOC:yaf, PMID:20711475]"}
{"concept_id": "C3821064", "aliases": [], "types": ["T043"], "canonical_name": "lateral motor column neuron migration", "definition": "The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme. [CL:0011002, GOC:yaf, PMID:20711475]"}
{"concept_id": "C3821065", "aliases": ["membrane leaflet"], "types": ["T024"], "canonical_name": "leaflet of membrane bilayer", "definition": "Any of the two layers of lipid molecules that constitute a membrane. [GOC:cjm]"}
{"concept_id": "C3821066", "aliases": ["synaptic vesicle localisation", "establishment and maintenance of synaptic vesicle localization", "establishment and maintenance of synaptic vesicle position"], "types": ["T038"], "canonical_name": "synaptic vesicle localization", "definition": "Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. [GOC:pr]"}
{"concept_id": "C3821067", "aliases": ["establishment of synaptic vesicle localisation"], "types": ["T043"], "canonical_name": "establishment of synaptic vesicle localization", "definition": "The directed movement of a synaptic vesicle or vesicles to a specific location. [GOC:pr]"}
{"concept_id": "C3821069", "aliases": ["muscle fiber postsynaptic density", "muscle cell postsynaptic density"], "types": ["T026"], "canonical_name": "muscle cell postsynaptic specialization", "definition": "A postsynaptic specialization that is part of a neuromuscular junction. [GOC:pr]"}
{"concept_id": "C3821071", "aliases": [], "types": ["T043"], "canonical_name": "dendrite extension", "definition": "Long distance growth of a single dendrite involved in cellular development. [GOC:BHF, GOC:rl]"}
{"concept_id": "C3821072", "aliases": ["neuron protrusion guidance", "neuron process guidance", "neuronal cell projection guidance"], "types": ["T043"], "canonical_name": "neuron projection guidance", "definition": "The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:rl, PMID:22790009]"}
{"concept_id": "C3821073", "aliases": [], "types": ["T043"], "canonical_name": "neurite guidance"}
{"concept_id": "C3821074", "aliases": [], "types": ["T026"], "canonical_name": "multivesicular body lumen", "definition": "The volume enclosed by the outermost membrane of a multivesicular body. [GOC:pde, PMID:21183070]"}
{"concept_id": "C3821075", "aliases": [], "types": ["T026"], "canonical_name": "multivesicular body, internal vesicle membrane", "definition": "The lipid bilayer surrounding a multivesicular body internal vesicle. [GOC:pde, PMID:21183070]"}
{"concept_id": "C3821076", "aliases": [], "types": ["T026"], "canonical_name": "multivesicular body, internal vesicle lumen", "definition": "The volume enclosed by the membrane of the multivesicular body internal vesicle. [GOC:pde, PMID:21183070]"}
{"concept_id": "C3821077", "aliases": ["sympathetic neuron process extension", "sympathetic neuronal cell projection extension", "sympathetic neuron protrusion extension"], "types": ["T043"], "canonical_name": "sympathetic neuron projection extension", "definition": "Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:BHF, GOC:rl, PMID:22790009]"}
{"concept_id": "C3821078", "aliases": [], "types": ["T043"], "canonical_name": "sympathetic neurite extension"}
{"concept_id": "C3821079", "aliases": ["sympathetic neuronal cell projection guidance", "sympathetic neuron protrusion guidance", "sympathetic neuron process guidance"], "types": ["T043"], "canonical_name": "sympathetic neuron projection guidance", "definition": "The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:rl, PMID:22790009]"}
{"concept_id": "C3821080", "aliases": [], "types": ["T043"], "canonical_name": "sympathetic neurite guidance"}
{"concept_id": "C3821081", "aliases": ["sympathetic neuron axon pathfinding"], "types": ["T043"], "canonical_name": "sympathetic neuron axon guidance", "definition": "The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:rl, PMID:22790009]"}
{"concept_id": "C3821082", "aliases": [], "types": ["T043"], "canonical_name": "sympathetic neuron axon chemotaxis"}
{"concept_id": "C3821083", "aliases": [], "types": ["T043"], "canonical_name": "sympathetic neuron axon growth cone guidance"}
{"concept_id": "C3821084", "aliases": [], "types": ["T044"], "canonical_name": "structural molecule activity conferring elasticity", "definition": "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling. [GOC:BHF, GOC:rl, PMID:23283722]"}
{"concept_id": "C3821085", "aliases": [], "types": ["T039"], "canonical_name": "regulation of vesicle size", "definition": "Any process that modulates the size of a vesicle. [GOC:pm, PMID:20007772]"}
{"concept_id": "C3821086", "aliases": ["H-NS-Hha complex location"], "types": ["T026"], "canonical_name": "H-NS-Hha complex", "definition": "A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes. [GOC:bhm, PMID:21600204]"}
{"concept_id": "C3821087", "aliases": [], "types": ["T042"], "canonical_name": "blood vessel lumen ensheathment", "definition": "A blood vessel lumenization process that occurs by blood vessel endothelial cells delaminating and aligning along the inner surface of an existing luminal space, extending the open ended lumen, and joining to other blood vessels to form a complete blood vessel. [GOC:dgh, PMID:23698350]"}
{"concept_id": "C3821088", "aliases": [], "types": ["T043"], "canonical_name": "blood vessel endothelial cell delamination", "definition": "The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet. [GOC:dgh, PMID:23698350]"}
{"concept_id": "C3821089", "aliases": [], "types": ["T042"], "canonical_name": "endothelial tube lumen extension", "definition": "Any endothelial tube morphogenesis process by which the tube is increased in length. [GOC:dgh, PMID:23698350]"}
{"concept_id": "C3821090", "aliases": ["protein localization to nonmotile primary cilium"], "types": ["T043"], "canonical_name": "protein localization to nonmotile primary cilium"}
{"concept_id": "C3821091", "aliases": [], "types": ["T043"], "canonical_name": "receptor localization to nonmotile primary cilium"}
{"concept_id": "C3821092", "aliases": ["response to metal ion stress"], "types": ["T039"], "canonical_name": "stress response to metal ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus. [GOC:kmv]"}
{"concept_id": "C3821093", "aliases": [], "types": ["T039"], "canonical_name": "response to excess metal ion"}
{"concept_id": "C3821094", "aliases": [], "types": ["T039"], "canonical_name": "response to metal ion toxicity"}
{"concept_id": "C3821095", "aliases": [], "types": ["T039"], "canonical_name": "response to metal toxicity"}
{"concept_id": "C3821096", "aliases": [], "types": ["T070"], "canonical_name": "mannosylation", "definition": "The covalent attachment of a mannose residue to a substrate molecule. [GOC:cjm]"}
{"concept_id": "C3821097", "aliases": ["Rad6-Rad18 complex location"], "types": ["T026"], "canonical_name": "Rad6-Rad18 complex", "definition": "A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity. [GOC:jd, PMID:9287349]"}
{"concept_id": "C3821098", "aliases": ["deaminated base DNA glycosylase activity", "DNA glycosylase activity acting on deaminated bases"], "types": ["T045"], "canonical_name": "deaminated base DNA N-glycosylase activity", "definition": "DNA N-glycosylase activity acting on deaminated bases. [GOC:al, PMID:18789404]"}
{"concept_id": "C3821099", "aliases": [], "types": ["T045"], "canonical_name": "hypoxanthine DNA N-glycosylase activity", "definition": "DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine). [GOC:al, PMID:18789404]"}
{"concept_id": "C3821100", "aliases": [], "types": ["T045"], "canonical_name": "xanthine DNA N-glycosylase activity", "definition": "DNA N-glycosylase activity acting on deaminated guanine (xanthine). [GOC:al, PMID:18789404]"}
{"concept_id": "C3821101", "aliases": [], "types": ["T045"], "canonical_name": "xanthine-DNA glycosylase activity"}
{"concept_id": "C3821102", "aliases": [], "types": ["T045"], "canonical_name": "oxanine DNA N-glycosylase activity", "definition": "DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination. [GOC:al, PMID:18789404]"}
{"concept_id": "C3821103", "aliases": [], "types": ["T045"], "canonical_name": "oxanine-DNA glycosylase activity"}
{"concept_id": "C3821104", "aliases": [], "types": ["T045"], "canonical_name": "base-excision repair, AP site formation via deaminated base removal", "definition": "A base-excision repair, AP site formation process occurring via excision of a deaminated base. [GOC:al, PMID:18789404]"}
{"concept_id": "C3821105", "aliases": [], "types": ["T026"], "canonical_name": "dendritic cell dendrite", "definition": "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. [CL:0000451, GOC:BHF, GOC:cjm, PMID:12200351]"}
{"concept_id": "C3821106", "aliases": [], "types": ["T026"], "canonical_name": "cardiac myofibril", "definition": "A cardiac myofibril is a myofibril specific to cardiac muscle cells. [GOC:cjm, GOC:devbiol]"}
{"concept_id": "C3821107", "aliases": [], "types": ["T026"], "canonical_name": "myosin II filament", "definition": "A bipolar filament composed of myosin II molecules. [GOC:cjm, GOC:mah]"}
{"concept_id": "C3821108", "aliases": [], "types": ["T026"], "canonical_name": "sexual spore wall", "definition": "A specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis. [GOC:cjm, GOC:mah]"}
{"concept_id": "C3821109", "aliases": [], "types": ["T026"], "canonical_name": "asexual spore wall", "definition": "A specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in bacterial and fungal species. [GOC:cjm, GOC:mah]"}
{"concept_id": "C3821110", "aliases": [], "types": ["T026"], "canonical_name": "microvillar actin bundle", "definition": "A parallel bundle of actin filaments at the core of a microvillus. [GOC:cjm, GOC:mah]"}
{"concept_id": "C3821111", "aliases": [], "types": ["T026"], "canonical_name": "contractile actin filament bundle", "definition": "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. [GOC:cjm, GOC:mah, ISBN:0815316194]"}
{"concept_id": "C3821112", "aliases": [], "types": ["T026"], "canonical_name": "parallel actin filament bundle", "definition": "An actin filament bundle in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity. [GOC:cjm, GOC:mah, ISBN:0815316194]"}
{"concept_id": "C3821113", "aliases": ["DNA recombinase complex location"], "types": ["T026"], "canonical_name": "DNA recombinase complex", "definition": "A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA. [GOC:cjm, PMID:10357855]"}
{"concept_id": "C3821114", "aliases": ["nucleotide-excision repair, preincision complex location"], "types": ["T026"], "canonical_name": "nucleotide-excision repair, preincision complex", "definition": "A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. [GOC:cjm, GOC:elh, PMID:10197977]"}
{"concept_id": "C3821115", "aliases": ["UvrA(2)-UvrB(2) complex location"], "types": ["T026"], "canonical_name": "UvrA(2)-UvrB(2) complex"}
{"concept_id": "C3821116", "aliases": ["UvrA(2)B(2) complex location"], "types": ["T026"], "canonical_name": "UvrA(2)B(2) complex"}
{"concept_id": "C3821117", "aliases": [], "types": ["T026"], "canonical_name": "UvrB dimer"}
{"concept_id": "C3821118", "aliases": ["protein-DNA ISRE complex location"], "types": ["T026"], "canonical_name": "protein-DNA ISRE complex", "definition": "A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA. [GOC:amm, GOC:cjm, PMID:11747630]"}
{"concept_id": "C3821119", "aliases": ["transcription protein-DNA-RNA complex location", "transcription protein-DNA-RNA complex", "transcription ternary complex location"], "types": ["T026"], "canonical_name": "transcription ternary complex", "definition": "A protein-DNA-RNA complex composed of RNA polymerase, template DNA, and an RNA transcript. [GOC:cjm, GOC:txnOH]"}
{"concept_id": "C3821120", "aliases": [], "types": ["T026"], "canonical_name": "sperm plasma membrane", "definition": "A plasma membrane that is part of a sperm cell. [GOC:cjm]"}
{"concept_id": "C3821121", "aliases": ["spliceosomal snRNP complex location"], "types": ["T026"], "canonical_name": "spliceosomal snRNP complex", "definition": "A small ribonucleoprotein complex involved in formation of the spliceosome. [GOC:krc, GOC:pr, ISBN:0879695897]"}
{"concept_id": "C3821122", "aliases": ["spliceosomal tri-snRNP complex location"], "types": ["T026"], "canonical_name": "spliceosomal tri-snRNP complex", "definition": "A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP. [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]"}
{"concept_id": "C3821123", "aliases": ["necroptotic signalling pathway", "necroptotic signal transduction", "necroptosis signaling pathway"], "types": ["T043"], "canonical_name": "necroptotic signaling pathway", "definition": "The series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered. [GOC:mtg_apoptosis, PMID:20823910]"}
{"concept_id": "C3821124", "aliases": [], "types": ["T043"], "canonical_name": "necroptosis signaling"}
{"concept_id": "C3821126", "aliases": ["execution phase of necroptotic process", "necroptotic execution phase"], "types": ["T043"], "canonical_name": "execution phase of necroptosis", "definition": "A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died. [GOC:mtg_apoptosis, PMID:20823910]"}
{"concept_id": "C3821127", "aliases": [], "types": ["T043"], "canonical_name": "myeloid leukocyte migration", "definition": "The movement of a myeloid leukocyte within or between different tissues and organs of the body. [GOC:cvs, PMID:22342843, PMID:24157461]"}
{"concept_id": "C3821128", "aliases": [], "types": ["T043"], "canonical_name": "granulocyte migration", "definition": "The movement of a granulocyte within or between different tissues and organs of the body. [GOC:cvs, PMID:24163421, PMID:24193336]"}
{"concept_id": "C3821129", "aliases": ["response to acid stress"], "types": ["T040"], "canonical_name": "stress response to acid"}
{"concept_id": "C3821130", "aliases": ["cellular response to acid stress"], "types": ["T043"], "canonical_name": "cellular stress response to acid"}
{"concept_id": "C3821131", "aliases": ["lymphoid lineage restricted progenitor cell migration"], "types": ["T043"], "canonical_name": "lymphoid lineage cell migration", "definition": "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage. [GOC:pr, PMID:22342843]"}
{"concept_id": "C3821132", "aliases": ["lymphoid lineage restricted progenitor cell migration into thymus"], "types": ["T043"], "canonical_name": "lymphoid lineage cell migration into thymus", "definition": "The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process. [GOC:cvs, PMID:22342843]"}
{"concept_id": "C3821133", "aliases": ["thymic epithelium morphogenesis"], "types": ["T042"], "canonical_name": "thymus epithelium morphogenesis", "definition": "The process in which the thymus epithelium is generated and organized. [GOC:pr, PMID:22342843]"}
{"concept_id": "C3821134", "aliases": ["Y-shaped link", "membrane-microtubule complex", "Y-link structure", "Y-shaped linker", "membrane-microtubule complex location", "Y-shaped fiber", "Y-shaped assemblage", "Y-shaped fibre"], "types": ["T026"], "definition": "A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium. [GOC:cilia, PMID:22653444, PMID:4554367]", "canonical_name": "Y-link"}
{"concept_id": "C3821135", "aliases": ["cilial necklace", "cilium necklace"], "types": ["T026"], "canonical_name": "ciliary necklace", "definition": "A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links. [GOC:cilia, PMID:22653444, PMID:4554367]"}
{"concept_id": "C3821136", "aliases": ["cilium transition fibre", "ciliary transition fibre", "cilium transition fiber", "cilial transition fiber", "cilial transition fibre"], "types": ["T026"], "canonical_name": "ciliary transition fiber", "definition": "A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium). [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827]"}
{"concept_id": "C3821137", "aliases": ["transition fibre"], "types": ["T026"], "canonical_name": "transition fiber"}
{"concept_id": "C3821138", "aliases": ["axoneme microtubule central pair", "central pair", "axoneme central pair", "central-pair microtubules", "axonemal microtubule central pair"], "types": ["T026"], "canonical_name": "axonemal central pair", "definition": "Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia. [GOC:cilia, GOC:krc, PMID:24283352]"}
{"concept_id": "C3821139", "aliases": ["axoneme basal plate"], "types": ["T026"], "canonical_name": "axonemal basal plate", "definition": "Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure. [GOC:cilia, PMID:23352055, PMID:4554367]"}
{"concept_id": "C3821140", "aliases": ["cilium inversin compartment", "Inv compartment of the cilium", "flagellar inversin compartment", "flagellum inversin compartment", "cilial inversin compartment"], "types": ["T026"], "canonical_name": "ciliary inversin compartment", "definition": "Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium. [GOC:cilia, PMID:19050042]"}
{"concept_id": "C3821141", "aliases": [], "types": ["T026"], "canonical_name": "inversin compartment"}
{"concept_id": "C3821142", "aliases": ["outer-doublet microtubules", "outer doublet", "axoneme outer doublet"], "types": ["T026"], "canonical_name": "axonemal outer doublet", "definition": "Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium. [GOC:cilia, GOC:krc, GOC:pr, PMID:5044758, PMID:5664206, Wikipedia:Axoneme]"}
{"concept_id": "C3821143", "aliases": ["flagellum base", "cilial base", "cilium base", "flagellar base"], "types": ["T026"], "canonical_name": "ciliary base", "definition": "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. [GOC:cilia, GOC:krc, PMID:22653444]"}
{"concept_id": "C3821144", "aliases": ["STV"], "types": ["T026"], "definition": "A cytoplasmic vesicle composed of both tubulovesicular and clear core vesicles that transport synaptic vesicle-associated proteins. Proteins carried by synaptic vesicle protein transport vesicles (STVs) include synaptophysin, synapsin Ia, synaptotagmin and synaptobrevin/vesicle-associated membrane protein 2 (VAMP2). STVs are packaged via the trans-Golgi network before being transported through the axon. [GOC:dr, PMID:21569270]", "canonical_name": "synaptic vesicle protein transport vesicle"}
{"concept_id": "C3821145", "aliases": [], "types": ["T040"], "canonical_name": "seed abscission", "definition": "The controlled shedding of a seed. [GOC:lmo]"}
{"concept_id": "C3821147", "aliases": ["mtDSB repair"], "types": ["T045"], "canonical_name": "mitochondrial double-strand break repair", "definition": "The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:di, PMID:22214610]"}
{"concept_id": "C3821148", "aliases": ["mtDSB repair via homologous recombination"], "types": ["T045"], "canonical_name": "mitochondrial double-strand break repair via homologous recombination", "definition": "The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences. [GOC:di, PMID:22214610]"}
{"concept_id": "C3821149", "aliases": [], "types": ["T044"], "canonical_name": "calcium ion transmembrane import into cytosol", "definition": "A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore. [GOC:vw]"}
{"concept_id": "C3821150", "aliases": [], "types": ["T044"], "canonical_name": "calcium transmembrane import into cytosol"}
{"concept_id": "C3821151", "aliases": ["left anterior cilium"], "types": ["T026"], "canonical_name": "left anterior flagellum", "definition": "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821152", "aliases": ["right anterior cilium"], "types": ["T026"], "canonical_name": "right anterior flagellum", "definition": "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821153", "aliases": ["left posteriolateral cilium", "left posterolateral flagellum", "left posterolateral cilium"], "types": ["T026"], "canonical_name": "left posteriolateral flagellum", "definition": "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821154", "aliases": ["right posteriolateral cilium", "right posterolateral cilium", "right posterolateral flagellum"], "types": ["T026"], "canonical_name": "right posteriolateral flagellum", "definition": "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821155", "aliases": ["left ventral cilium"], "types": ["T026"], "canonical_name": "left ventral flagellum", "definition": "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left ventral basal body and exits the cell body proximally and dorsal to the ventral disc. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821156", "aliases": ["right ventral cilium"], "types": ["T026"], "canonical_name": "right ventral flagellum", "definition": "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right ventral basal body and exits the cell body proximally and dorsal to the ventral disc. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821157", "aliases": ["left caudal cilium"], "types": ["T026"], "canonical_name": "left caudal flagellum", "definition": "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821158", "aliases": ["right caudal cilium"], "types": ["T026"], "canonical_name": "right caudal flagellum", "definition": "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821159", "aliases": [], "types": ["T026"], "canonical_name": "left lateral basal body pair", "definition": "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821160", "aliases": [], "types": ["T026"], "canonical_name": "left middle basal body pair", "definition": "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821161", "aliases": [], "types": ["T026"], "canonical_name": "right lateral basal body pair", "definition": "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821162", "aliases": [], "types": ["T026"], "canonical_name": "right middle basal body pair", "definition": "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally. [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821163", "aliases": [], "types": ["T026"], "canonical_name": "left tetrad", "definition": "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the left lateral basal body pair and the left middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally). [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821164", "aliases": [], "types": ["T026"], "canonical_name": "right tetrad", "definition": "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the right lateral basal body pair and the right middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally). [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3821165", "aliases": [], "types": ["T026"], "canonical_name": "median body", "definition": "A non-membrane bound, semi-organized microtubule array of unknown function found in Giardia species (trophozoite stage). It is located on the dorsal side of the trophozoite, slightly posterior to the ventral disc. [GOC:giardia, PMID:5961344]"}
{"concept_id": "C3821166", "aliases": [], "types": ["T026"], "canonical_name": "lateral shield", "definition": "Region of the ventral side of the cell body found in Giardia species (trophozoite stage). It is located posterior on either side of the ventral groove; the upper boundary is the ventral disc, and the lower boundary is marked by the posteriolateral flagella. [GOC:giardia, ISBN:9780124260207]"}
{"concept_id": "C3821167", "aliases": [], "types": ["T026"], "canonical_name": "cyst wall", "definition": "The specialized envelope lying outside the cell membrane of a cyst. A cyst is a resting or dormant stage of a microorganism, usually a bacterium or a protist or rarely an invertebrate animal, that helps the organism to survive in unfavorable environmental conditions. In protists such as protozoan parasites alternating cystic- and non-cystic stages, the cyst wall is usually composed of carbohydrates and proteins. [GOC:giardia, PMID:15134259, PMID:2026212, Wikipedia:Microbial_cyst]"}
{"concept_id": "C3821168", "aliases": [], "types": ["T026"], "canonical_name": "left nucleus", "definition": "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the left side of the cell when viewed from the dorsal side. [GOC:giardia, ISBN:0-444-81258-X]"}
{"concept_id": "C3821169", "aliases": [], "types": ["T026"], "canonical_name": "right nucleus", "definition": "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the right side of the cell when viewed from the dorsal side. [GOC:giardia, ISBN:0-444-81258-X]"}
{"concept_id": "C3821170", "aliases": [], "types": ["T044"], "canonical_name": "glutathione oxidoreductase activity", "definition": "Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione. [GOC:jd, PMID:18992757]"}
{"concept_id": "C3821171", "aliases": [], "types": ["T026"], "canonical_name": "lateral part of cell", "definition": "The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells. [GOC:pr]"}
{"concept_id": "C3821172", "aliases": [], "types": ["T026"], "canonical_name": "lateral cell cortex", "definition": "The region directly beneath the plasma membrane of the lateral portion of the cell. [GOC:mah, PMID:24146635]"}
{"concept_id": "C3821173", "aliases": ["storage of iron ion", "sequestration of iron ion", "iron ion sequestration", "iron ion sequestering", "retention of iron ion", "iron ion retention", "iron ion storage"], "types": ["T038"], "canonical_name": "sequestering of iron ion", "definition": "The process of binding or confining iron ions such that they are separated from other components of a biological system. [GOC:mr, PMID:3099306]"}
{"concept_id": "C3821174", "aliases": ["copper ion sequestering", "copper ion retention", "sequestration of copper ion", "storage of copper ion", "retention of copper ion", "copper ion storage", "copper ion sequestration"], "types": ["T043"], "canonical_name": "sequestering of copper ion", "definition": "The process of binding or confining copper ions such that they are separated from other components of a biological system. [GOC:mr, PMID:3099306]"}
{"concept_id": "C3821175", "aliases": ["extracellular copper ion sequestering", "extracellular storage of copper ion", "extracellular retention of copper ion", "extracellular copper ion storage", "extracellular sequestration of copper ion", "extracellular copper ion retention", "extracellular copper ion sequestration"], "types": ["T043"], "canonical_name": "extracellular sequestering of copper ion", "definition": "The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system. [GOC:mr, PMID:3099306]"}
{"concept_id": "C3821176", "aliases": ["intracellular sequestration of copper ion", "intracellular copper ion sequestering", "intracellular copper ion retention", "intracellular retention of copper ion", "intracellular copper ion storage", "intracellular copper ion sequestration", "intracellular storage of copper ion"], "types": ["T038"], "canonical_name": "intracellular sequestering of copper ion", "definition": "The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system. [GOC:mr, PMID:3099306]"}
{"concept_id": "C3821177", "aliases": ["dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex location"], "types": ["T026"], "canonical_name": "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex", "definition": "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt2p. [GOC:jd, PMID:12551906]"}
{"concept_id": "C3821178", "aliases": ["Pmt1p-Pmt2p complex location"], "types": ["T026"], "canonical_name": "Pmt1p-Pmt2p complex"}
{"concept_id": "C3821179", "aliases": ["dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex location"], "types": ["T026"], "canonical_name": "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex", "definition": "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p. [GOC:jd, PMID:12551906]"}
{"concept_id": "C3821180", "aliases": ["Pmt1p-Pmt3p complex location"], "types": ["T026"], "canonical_name": "Pmt1p-Pmt3p complex"}
{"concept_id": "C3821181", "aliases": ["dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex location", "Pmt5p-Pmt2p complex", "Pmt5p-Pmt2p complex location"], "types": ["T026"], "canonical_name": "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex", "definition": "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p. [GOC:jd, PMID:12551906]"}
{"concept_id": "C3821182", "aliases": ["Pmt5p-Pmt3p complex", "Pmt5p-Pmt3p complex location", "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex location"], "types": ["T026"], "canonical_name": "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex", "definition": "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p. [GOC:jd, PMID:12551906]"}
{"concept_id": "C3821183", "aliases": ["dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer", "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p-Pmt4p dimer complex", "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p-Pmt4p dimer complex location", "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex location"], "types": ["T026"], "canonical_name": "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex", "definition": "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p. [GOC:bhm, GOC:jd, PMID:12551906]"}
{"concept_id": "C3821184", "aliases": ["Pmt4p-Pmt4p complex location"], "types": ["T026"], "canonical_name": "Pmt4p-Pmt4p complex"}
{"concept_id": "C3821185", "aliases": ["MutLgamma complex location"], "types": ["T026"], "canonical_name": "MutLgamma complex", "definition": "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3. [GOC:jd, PMID:10570173]"}
{"concept_id": "C3821186", "aliases": [], "types": ["T043"], "canonical_name": "archaeal or bacterial-type flagellum-dependent cell motility", "definition": "Cell motility due to movement of bacterial- or archaeal-type flagella. [GOC:cilia, GOC:krc]"}
{"concept_id": "C3821187", "aliases": ["archaella", "archaellum", "archaeal flagellum"], "types": ["T026"], "canonical_name": "archaeal-type flagellum", "definition": "A non-membrane-bounded organelle superficially similar to a bacterial-type flagellum; they both consist of filaments extending outside the cell, and rotate to propel the cell, but the archaeal flagella (also called archaella) have a unique structure which lacks a central channel. Similar to bacterial type IV pilins, the archaeal flagellins (archaellins) are made with class 3 signal peptides and they are processed by a type IV prepilin peptidase-like enzyme. The archaellins are typically modified by the addition of N-linked glycans which are necessary for proper assembly and/or function. [GOC:cilia, GOC:krc, PMID:21265748, PMID:23146836, PMID:23204365, PMID:24330313, Wikipedia:Flagellum#Archaeal]"}
{"concept_id": "C3821188", "aliases": [], "types": ["T043"], "canonical_name": "archaeal-type flagellum-dependent cell motility", "definition": "Cell motility due to the motion of one or more archaeal-type flagella. An archaeal-type flagellum (also called archaellum) is a non-membrane-bounded organelle superficially similar to a bacterial-type flagellum, but having a different molecular structure and lacking a central channel. [GOC:cilia, GOC:krc, Wikipedia:Flagellum#Archaeal]"}
{"concept_id": "C3821189", "aliases": [], "types": ["T043"], "canonical_name": "archaeal-type flagellar cell motility"}
{"concept_id": "C3821190", "aliases": ["ventral disk lateral crest"], "types": ["T026"], "canonical_name": "ventral disc lateral crest", "definition": "Fibrillar repetitive structure surrounding the ventral disc edge in Giardia species (trophozoite stage). The composition of the lateral crest is not fully known yet. [GOC:giardia]"}
{"concept_id": "C3821191", "aliases": [], "types": ["T026"], "canonical_name": "lateral crest"}
{"concept_id": "C3821193", "aliases": ["ventral disk overlap zone"], "types": ["T026"], "canonical_name": "ventral disc overlap zone", "definition": "A region of the ventral disc of Giardia species (trophozoite stage) where two portions of the same array of microtubules overlap (the microtubule array makes a complete circle and overlaps on itself). [GOC:giardia]"}
{"concept_id": "C3821194", "aliases": [], "types": ["T026"], "canonical_name": "overlap zone"}
{"concept_id": "C3821196", "aliases": ["ventral disk microtubule array", "ventral disc spiral microtubule array"], "types": ["T026"], "canonical_name": "ventral disc microtubule array", "definition": "A part of the ventral disc of Giardia species (trophozoite stage) consisting of a spiral array of microtubules linked to the ventral membrane. These microtubules form the base of the ventral disc dorsal microribbons that extend nearly perpendicular from the membrane. [GOC:giardia]"}
{"concept_id": "C3821197", "aliases": [], "types": ["T026"], "canonical_name": "spiral microtubule array"}
{"concept_id": "C3821199", "aliases": ["ventral disk dorsal microribbon", "dorsal ribbon", "dorsal microribbon", "microribbon"], "types": ["T026"], "canonical_name": "ventral disc dorsal microribbon", "definition": "Trilaminar structure extending perpendicularly into the cytoplasm along the length of ventral disc microtubules in Giardia species (trophozoite stage). Constituents of dorsal microribbons (also called dorsal ribbons or microribbons) include alpha-coiled-helix proteins approximately 29 to 38 kDa in size. These proteins line the edges of the microribbons but are not found in microtubules. Tubulins are not found in microribbons. [GOC:giardia, PMID:11432808]"}
{"concept_id": "C3821200", "aliases": ["ventral disk crossbridge", "crossbridge"], "types": ["T026"], "canonical_name": "ventral disc crossbridge", "definition": "Structure horizontally linking adjacent microribbons of the ventral disc in Giardia species (trophozoite stage). The composition of crossbridges is not fully known yet. [GOC:giardia]"}
{"concept_id": "C3821201", "aliases": ["ventral disk supernumerary microtubule array"], "types": ["T026"], "canonical_name": "ventral disc supernumerary microtubule array", "definition": "A partial left-handed spiral array of microtubules that lies generally dorsal to the main ventral disc microtubule array in Giardia species (trophozoite stage). [GOC:giardia, ISBN:9780124260207]"}
{"concept_id": "C3821202", "aliases": [], "types": ["T026"], "canonical_name": "supernumerary microtubule array"}
{"concept_id": "C3821204", "aliases": ["ventral disk", "ventral adhesive disc"], "types": ["T026"], "canonical_name": "ventral disc", "definition": "Specialized organelle found in Giardia species (trophozoite stage) and characterized by a spiral array of microtubules and microtubule-associated structures including dorsal microribbons and crossbridges. The edge of the ventral disc narrows into a lateral crest. The ventral disk mediates mechanical attachment of the trophozoite to the host's intestinal wall, and contains the contractile proteins actinin, alpha-actinin, myosin, and tropomyosin working towards contraction of the disk involved in adherence. [GOC:giardia, ISBN:9780124260207, PMID:11432808, PMID:4777416, PMID:5961344]"}
{"concept_id": "C3821205", "aliases": [], "types": ["T026"], "canonical_name": "adhesive disc"}
{"concept_id": "C3821207", "aliases": ["sperm residual cytoplasm"], "types": ["T026"], "canonical_name": "sperm cytoplasmic droplet", "definition": "A small amount of cytoplasm surrounded by a cell membrane that is generally retained in spermatozoa after spermiogenesis, when the majority of the cytoplasm is phagocytosed by Sertoli cells to produce what are called residual bodies. Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from 'excessive residual cytoplasm' that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted. [GOC:krc, GOC:vesicles, PMID:12672117, PMID:21076437, PMID:23159014]"}
{"concept_id": "C3821208", "aliases": [], "types": ["T044"], "canonical_name": "xylosidase activity"}
{"concept_id": "C3821209", "aliases": ["maintenance of retina blood vessel", "maintenance of retinal blood vessel"], "types": ["T042"], "canonical_name": "retina blood vessel maintenance", "definition": "A retina homeostatic process preventing the degeneration of a retina blood vessel. [GOC:jh2, PMID:23093773]"}
{"concept_id": "C3821210", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of choriocapillaris"}
{"concept_id": "C3821211", "aliases": [], "types": ["T044"], "canonical_name": "cullin family protein binding", "definition": "Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). [GOC:ha, InterPro:IPR016158, PMID:18698375]"}
{"concept_id": "C3821212", "aliases": [], "types": ["T044"], "canonical_name": "cullin binding"}
{"concept_id": "C3821213", "aliases": ["temperature-activated ion channel activity", "temperature gated ion channel activity", "temperature-dependent ion channel activity"], "types": ["T044"], "canonical_name": "temperature-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). [GOC:ha, GOC:pr, PMID:23027824]"}
{"concept_id": "C3821214", "aliases": [], "types": ["T044"], "canonical_name": "heat-activated ion channel activity"}
{"concept_id": "C3821215", "aliases": ["temperature gated cation channel activity", "temperature-activated cation channel activity", "temperature-dependent cation channel activity"], "types": ["T044"], "canonical_name": "temperature-gated cation channel activity", "definition": "Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). [GOC:ha, GOC:pr, PMID:23027824]"}
{"concept_id": "C3821216", "aliases": [], "types": ["T044"], "canonical_name": "heat-activated cation channel activity"}
{"concept_id": "C3821224", "aliases": [], "types": ["T045"], "canonical_name": "G-rich strand telomeric DNA binding", "definition": "Binding to G-rich, single-stranded, telomere-associated DNA. [PMID:11349150]"}
{"concept_id": "C3821225", "aliases": [], "types": ["T044"], "canonical_name": "polynucleotide 3' dephosphorylation", "definition": "The process of removing one or more phosphate groups from the 3' end of a polynucleotide. [GOC:dos]"}
{"concept_id": "C3821226", "aliases": [], "types": ["T044"], "canonical_name": "polynucleotide 5' dephosphorylation", "definition": "The process of removing one or more phosphate groups from the 5' end of a polynucleotide. [GOC:dos]"}
{"concept_id": "C3821227", "aliases": [], "types": ["T043"], "canonical_name": "endothelial to hematopoietic transition", "definition": "The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium. [PMID:20154732, PMID:22521721]"}
{"concept_id": "C3821228", "aliases": ["hygrosensory perception"], "types": ["T042"], "canonical_name": "sensory perception of humidity", "definition": "The series of events required for an organism to detect some level of humidity in its environment, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process. [PMID:18269908, PMID:8650222]"}
{"concept_id": "C3821229", "aliases": [], "types": ["T042"], "canonical_name": "sensory perception of high humidity", "definition": "The series of events required for an organism to detect high environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process. [PMID:18269908]"}
{"concept_id": "C3821230", "aliases": [], "types": ["T042"], "canonical_name": "sensory perception of low humidity", "definition": "The series of events required for an organism to detect low environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process. [PMID:18269908]"}
{"concept_id": "C3821231", "aliases": [], "types": ["T042"], "canonical_name": "detection of humidity stimulus involved in sensory perception", "definition": "The series of events in which a humidity stimulus is received and converted into a molecular signal as part of the sensory perception of humidity. [GOC:dos, PMID:8650222]"}
{"concept_id": "C3821232", "aliases": [], "types": ["T043"], "canonical_name": "detection of humidity", "definition": "The series of events in which a humidity stimulus is received and converted into a molecular signal. [GOC:dos]"}
{"concept_id": "C3821233", "aliases": [], "types": ["T042"], "canonical_name": "detection of high humidity stimulus involved in sensory perception", "definition": "The series of events in which a high humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of high humidity. [GOC:dos, PMID:18269908]"}
{"concept_id": "C3821234", "aliases": [], "types": ["T042"], "canonical_name": "detection of low humidity stimulus involved in sensory perception", "definition": "The series of events in which a low humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of low humidity. [GOC:dos, PMID:18269908]"}
{"concept_id": "C3821235", "aliases": [], "types": ["T043"], "canonical_name": "detection of high humidity", "definition": "The series of events in which high humidity is detected and converted into a molecular signal. [GOC:dos]"}
{"concept_id": "C3821236", "aliases": [], "types": ["T043"], "canonical_name": "detection of low humidity", "definition": "The series of events in which low humidity is detected and converted into a molecular signal. [GOC:dos]"}
{"concept_id": "C3821237", "aliases": [], "types": ["T044"], "canonical_name": "polynucleotide phosphatase activity", "definition": "Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate. [GOC:mah]"}
{"concept_id": "C3821238", "aliases": [], "types": ["T026"], "canonical_name": "excitatory neuromuscular junction", "definition": "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible for muscle contraction. [GOC:dos]"}
{"concept_id": "C3821239", "aliases": [], "types": ["T026"], "canonical_name": "inhibitory neuromuscular junction", "definition": "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential that inhibits muscle contraction. [GOC:dos]"}
{"concept_id": "C3821240", "aliases": [], "types": ["T026"], "canonical_name": "neuromuscular junction of skeletal muscle fiber", "definition": "A neuromuscular junction in which the target muscle cell is a skeletal muscle fiber. [GOC:dos]"}
{"concept_id": "C3821241", "aliases": [], "types": ["T026"], "canonical_name": "neuromuscular junction of myotube", "definition": "A neuromuscular junction in which the target muscle cell is a myotube. [GOC:dos]"}
{"concept_id": "C3821242", "aliases": [], "types": ["T026"], "canonical_name": "neuromuscular junction of somatic muscle myotube", "definition": "A neuromuscular junction in which the target muscle cell is a somatic muscle myotube, such as an arthropod somatic muscle cell. [GOC:dos]"}
{"concept_id": "C3821243", "aliases": [], "types": ["T026"], "canonical_name": "excitatory neuromuscular junction of somatic myotube", "definition": "A neuromuscular junction that functions in the excitation of somatic muscle myotubes, such as an arthropod somatic muscle cells. [GOC:dos]"}
{"concept_id": "C3821244", "aliases": [], "types": ["T026"], "canonical_name": "inhibitory neuromuscular junction of somatic myotube", "definition": "A neuromuscular junction that functions in the inhibition of somatic muscle myotube contraction. Examples of somatic muscle myotubes include the somatic muscle cells of arthropods. [GOC:dos]"}
{"concept_id": "C3821245", "aliases": [], "types": ["T026"], "canonical_name": "neuromuscular junction of somatic muscle", "definition": "A neuromuscular junction in which the target muscle cell is a somatic muscle cell, such as those found in nematodes and arthropods. [GOC:dos]"}
{"concept_id": "C3821246", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle fiber differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. [GOC:dos]"}
{"concept_id": "C3821247", "aliases": [], "types": ["T042"], "canonical_name": "neuromuscular junction development, skeletal muscle fiber", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber. [GOC:mtg_OBO2OWL_2013]"}
{"concept_id": "C3821248", "aliases": ["positive regulation of Rad51-mediated strand invasion"], "types": ["T045"], "canonical_name": "positive regulation of strand invasion", "definition": "Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. [GOC:dos, GOC:dph, GOC:elh, GOC:tb]"}
{"concept_id": "C3821249", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of D-loop biosynthesis"}
{"concept_id": "C3821250", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of D-loop formation"}
{"concept_id": "C3821251", "aliases": ["direct ligand regulated sequence-specific DNA binding transcription factor activity", "transcription factor activity, direct ligand regulated sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "ligand-activated transcription factor activity", "definition": "A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. [GOC:dos, PMID:25568920, PMID:8735275]"}
{"concept_id": "C3821252", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K27 trimethylation", "definition": "The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone. [PMID:19270745]"}
{"concept_id": "C3821253", "aliases": ["ATPase dependent transmembrane transport complex location"], "types": ["T026"], "canonical_name": "ATPase dependent transmembrane transport complex", "definition": "A transmembrane protein complex that functions in ATPase dependent active transport across a membrane. [GOC:dos]"}
{"concept_id": "C3821254", "aliases": [], "types": ["T043"], "canonical_name": "centriole assembly", "definition": "A cellular process that results in the assembly of one or more centrioles. [GOC:dos, PMID:24075808]"}
{"concept_id": "C3821255", "aliases": [], "types": ["T043"], "canonical_name": "centriole amplification"}
{"concept_id": "C3821256", "aliases": [], "types": ["T026"], "canonical_name": "deuterosome", "definition": "A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles. [GOC:cilia, GOC:dos, PMID:24075808, PMID:25047614, PMID:5661997]"}
{"concept_id": "C3821258", "aliases": ["internal side of transport vesicle membrane"], "types": ["T026"], "canonical_name": "lumenal side of transport vesicle membrane", "definition": "The side (leaflet) of the transport vesicle membrane that faces the lumen. [GOC:ab]"}
{"concept_id": "C3821259", "aliases": ["external side of transport vesicle membrane"], "types": ["T026"], "canonical_name": "cytoplasmic side of transport vesicle membrane", "definition": "The side (leaflet) of the transport vesicle membrane that faces the cytoplasm. [GOC:ab]"}
{"concept_id": "C3821260", "aliases": [], "types": ["T026"], "canonical_name": "lumenal side of trans-Golgi network transport vesicle membrane", "definition": "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the lumen. [GOC:ab]"}
{"concept_id": "C3821261", "aliases": [], "types": ["T026"], "canonical_name": "internal side of trans-Golgi network transport vesicle membrane"}
{"concept_id": "C3821262", "aliases": ["external side of trans-Golgi network transport vesicle membrane"], "types": ["T026"], "canonical_name": "cytoplasmic side of trans-Golgi network transport vesicle membrane", "definition": "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the cytoplasm. [GOC:ab]"}
{"concept_id": "C3821263", "aliases": [], "types": ["T040"], "canonical_name": "defense response to other organism", "definition": "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. [GOC:dos]"}
{"concept_id": "C3821264", "aliases": [], "types": ["T040"], "canonical_name": "detection of other organism", "definition": "The series of events in which a stimulus from another organism is received and converted into a molecular signal. [GOC:dos]"}
{"concept_id": "C3821265", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein complex location", "definition": "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away. [GOC:dos]"}
{"concept_id": "C3821266", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein complex location in cytoplasm", "definition": "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere. [GOC:dos]"}
{"concept_id": "C3821268", "aliases": [], "types": ["T026"], "canonical_name": "lumenal side of Golgi membrane", "definition": "The side of the Golgi membrane that faces the lumen. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821269", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic side of Golgi membrane", "definition": "The side (leaflet) of the Golgi membrane that faces the cytoplasm. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821270", "aliases": [], "types": ["T026"], "canonical_name": "somatic ring canal", "definition": "A stable intercellular bridge between somatic cells. Examples include the intercellular bridges between ovarian follicle cells in insects and between imaginal disc cells in insects. [GOC:dos, PMID:22135360, PMID:670316]"}
{"concept_id": "C3821271", "aliases": ["internal side of early endosome membrane", "internal leaflet of early endosome membrane"], "types": ["T026"], "canonical_name": "lumenal side of early endosome membrane", "definition": "The side (leaflet) of the early endosome membrane that faces the lumen. [GOC:lr]"}
{"concept_id": "C3821272", "aliases": ["internal side of late endosome membrane", "internal leaflet of late endosome membrane"], "types": ["T026"], "canonical_name": "lumenal side of late endosome membrane", "definition": "The side (leaflet) of the late endosome membrane that faces the lumen. [GOC:lr]"}
{"concept_id": "C3821273", "aliases": [], "types": ["T024"], "canonical_name": "side of membrane", "definition": "A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos]"}
{"concept_id": "C3821274", "aliases": [], "types": ["T026"], "canonical_name": "lumenal side of endoplasmic reticulum membrane", "definition": "The side (leaflet) of the plasma membrane that faces the lumen. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821275", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic side of endoplasmic reticulum membrane", "definition": "The side (leaflet) of the plasma membrane that faces the cytoplasm. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821276", "aliases": [], "types": ["T026"], "canonical_name": "lumenal side of rough endoplasmic reticulum membrane", "definition": "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the lumen. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821277", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic side of rough endoplasmic reticulum membrane", "definition": "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821278", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic side of smooth endoplasmic reticulum membrane", "definition": "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the cytoplasm. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821279", "aliases": [], "types": ["T026"], "canonical_name": "lumenal side of smooth endoplasmic reticulum membrane", "definition": "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the lumen. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821280", "aliases": ["external side of early endosome membrane", "external leaflet of early endosome membrane"], "types": ["T026"], "canonical_name": "cytoplasmic side of early endosome membrane", "definition": "The side (leaflet) of the early endosome membrane that faces the cytoplasm. [GOC:lr]"}
{"concept_id": "C3821281", "aliases": ["external side of late endosome membrane", "external leaflet of late endosome membrane"], "types": ["T026"], "canonical_name": "cytoplasmic side of late endosome membrane", "definition": "The side (leaflet) of the late endosome membrane that faces the cytoplasm. [GOC:lr]"}
{"concept_id": "C3821282", "aliases": ["methyl accepting chemotaxis protein complex location"], "types": ["T026"], "canonical_name": "methyl accepting chemotaxis protein complex", "definition": "A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus. [GOC:dos, PMID:1326408, PMID:15802240]"}
{"concept_id": "C3821283", "aliases": [], "types": ["T024"], "canonical_name": "cytoplasmic side of membrane", "definition": "The side of a membrane that faces the cytoplasm. [GOC:dos]"}
{"concept_id": "C3821284", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of synaptic vesicle membrane", "definition": "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos]"}
{"concept_id": "C3821285", "aliases": [], "types": ["T026"], "canonical_name": "trans-Golgi network transport vesicle lumen", "definition": "The volume enclosed within the membrane of a trans-Golgi network transport vesicle. [GOC:dos]"}
{"concept_id": "C3821286", "aliases": ["internal side of endosome membrane", "internal leaflet of endosome membrane"], "types": ["T026"], "canonical_name": "lumenal side of endosome membrane", "definition": "The side (leaflet) of the endosome membrane that faces the lumen. [GOC:dos]"}
{"concept_id": "C3821287", "aliases": [], "types": ["T026"], "canonical_name": "transport vesicle lumen", "definition": "The volume enclosed within the membrane of a transport vesicle. [GOC:dos]"}
{"concept_id": "C3821288", "aliases": [], "types": ["T026"], "canonical_name": "periplasmic side of plasma membrane", "definition": "The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface. [GOC:dos]"}
{"concept_id": "C3821289", "aliases": [], "types": ["T026"], "canonical_name": "external side of mycolate outer membrane", "definition": "The side (leaflet) of the mycolate outer membrane that faces the environment and any proteins embedded in it or loosely bound to its surface. [GOC:dos, PMID:18316738, PMID:18567661]"}
{"concept_id": "C3821290", "aliases": [], "types": ["T024"], "canonical_name": "internal side of mycolate outer membrane", "definition": "The side of the mycolate outer membrane that faces the cell wall peptidoglycan. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. [GOC:dos, PMID:18316738, PMID:18567661]"}
{"concept_id": "C3821291", "aliases": [], "types": ["T026"], "canonical_name": "stromal side of plastid inner membrane", "definition": "The side (leaflet) of the plastid inner membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface. [GOC:dos]"}
{"concept_id": "C3821292", "aliases": [], "types": ["T026"], "canonical_name": "lumenal side of plastid thylakoid membrane", "definition": "The side (leaflet) of the plastid thylakoid membrane that faces the lumen, and any proteins embedded in it or loosely bound to its surface. [GOC:dos]"}
{"concept_id": "C3821293", "aliases": [], "types": ["T026"], "canonical_name": "stromal side of plastid thylakoid membrane", "definition": "The side (leaflet) of the plastid thylakoid membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface. [GOC:dos]"}
{"concept_id": "C3821294", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of mitochondrial membrane", "definition": "The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos]"}
{"concept_id": "C3821295", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic to mitochondrial membrane"}
{"concept_id": "C3821296", "aliases": ["external leaflet of lysosomal membrane", "external side of lysosomal membrane"], "types": ["T026"], "canonical_name": "cytoplasmic side of lysosomal membrane", "definition": "The side (leaflet) of the lysosomal membrane that faces the cytoplasm. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821297", "aliases": ["internal leaflet of lysosomal membrane", "internal side of lysosomal membrane"], "types": ["T026"], "canonical_name": "lumenal side of lysosomal membrane", "definition": "The side (leaflet) of the lysosomal membrane that faces the lumen. [GOC:dos]"}
{"concept_id": "C3821298", "aliases": [], "types": ["T026"], "canonical_name": "lumenal side of membrane", "definition": "Any side (leaflet) of a membrane that faces the lumen of an organelle. [GOC:dos]"}
{"concept_id": "C3821299", "aliases": ["inactivated sex chromosome"], "types": ["T026"], "canonical_name": "inactive sex chromosome", "definition": "A sex chromosome that has been inactivated. [GOC:dos]"}
{"concept_id": "C3821300", "aliases": [], "types": ["T026"], "canonical_name": "condensed chromatin of inactivated sex chromosome", "definition": "A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation. [GOC:dos]"}
{"concept_id": "C3821301", "aliases": [], "types": ["T026"], "canonical_name": "active sex chromosome", "definition": "A sex chromosome that has not been inactivated. [GOC:dos]"}
{"concept_id": "C3821303", "aliases": ["detection of exogenous biotic stimulus"], "types": ["T043"], "canonical_name": "detection of external biotic stimulus", "definition": "The series of events in which an external biotic stimulus is detected and converted into a molecular signal. An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated. [GOC:dos]"}
{"concept_id": "C3821304", "aliases": [], "types": ["T055"], "canonical_name": "innate vocalization behavior", "definition": "A vocalisation behavior that is innate, i.e. that does not need to be learned in order to occur. [GOC:BHF, GOC:dos, GOC:rl]"}
{"concept_id": "C3821305", "aliases": [], "types": ["T055"], "canonical_name": "learned vocalization behavior", "definition": "A vocalization behavior that is the result of learning. [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]"}
{"concept_id": "C3821306", "aliases": [], "types": ["T026"], "canonical_name": "host cell synaptic vesicle", "definition": "A secretory organelle of a host cell, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. [GOC:dos]"}
{"concept_id": "C3821307", "aliases": [], "types": ["T026"], "canonical_name": "host cell synaptic vesicle membrane", "definition": "The lipid bilayer surrounding a host synaptic vesicle. [GOC:dos]"}
{"concept_id": "C3821308", "aliases": ["kinetochore clustering"], "types": ["T043"], "canonical_name": "centromere clustering", "definition": "The process by which centromeres/kinetochores become localized to clusters. [GOC:di, GOC:dos, PMID:10761928, PMID:23283988, PMID:8486732]"}
{"concept_id": "C3821309", "aliases": [], "types": ["T026"], "canonical_name": "bounding membrane of organelle", "definition": "The lipid bilayer that forms the outer-most layer of an organelle. [GOC:dos]"}
{"concept_id": "C3821311", "aliases": [], "types": ["T026"], "canonical_name": "external side of apical plasma membrane", "definition": "The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821312", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic side of apical plasma membrane", "definition": "The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm. [GOC:ab, GOC:dos]"}
{"concept_id": "C3821313", "aliases": [], "types": ["T026"], "canonical_name": "goblet cell theca", "definition": "A cup shaped specialization of the cytoskeleton that forms a thin layer located just below the apical mass of mature mucin secretory granules in the cytoplasm of goblet cells of the intestinal epithelium. It consists of an orderly network of intermediate filaments and microtubules. Microtubules are arranged vertically, like barrel staves, along the inner aspect of the theta. Intermediate filaments form two networks: an inner, basketlike network and an outer series of circumferential bundles resembling the hoops of a barrel. [PMID:6541604]"}
{"concept_id": "C3821314", "aliases": [], "types": ["T026"], "canonical_name": "mucin granule", "definition": "A secretory granule that contains mucin. [PMID:16377632]"}
{"concept_id": "C3821315", "aliases": [], "types": ["T041"], "canonical_name": "imitative learning", "definition": "Learning in which new behaviors are acquired through imitation. [GOC:dos, Wikipedia:Imitative_learning&oldid=593192364]"}
{"concept_id": "C3821316", "aliases": [], "types": ["T041"], "canonical_name": "learned vocalization behavior or vocal learning", "definition": "Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned. [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]"}
{"concept_id": "C3821317", "aliases": [], "types": ["T044"], "canonical_name": "palmitoyl hydrolase activity", "definition": "Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate. [GOC:dos, GOC:pg]"}
{"concept_id": "C3821318", "aliases": [], "types": ["T044"], "canonical_name": "selenomethionine gamma-lyase activity", "definition": "Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid. [PMID:11578145, PMID:16037612, PMID:16444005]"}
{"concept_id": "C3821319", "aliases": [], "types": ["T044"], "canonical_name": "selenomethionine adenosyltransferase activity", "definition": "Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine. [PMID:2339986]"}
{"concept_id": "C3821321", "aliases": [], "types": ["T044"], "canonical_name": "selenol Se-methyltransferase activity", "definition": "Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine. [PMID:1711890]"}
{"concept_id": "C3821322", "aliases": [], "types": ["T044"], "canonical_name": "adenosylselenohomocysteinase activity", "definition": "Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine. [GOC:dos, PMID:1711890, PMID:7305945]"}
{"concept_id": "C3821323", "aliases": [], "types": ["T044"], "canonical_name": "selenocystathionine beta-synthase activity", "definition": "Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O. [PMID:6456763]"}
{"concept_id": "C3821324", "aliases": [], "types": ["T044"], "canonical_name": "selenocystathionine gamma-lyase activity", "definition": "Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid. [PMID:6456763]"}
{"concept_id": "C3821325", "aliases": [], "types": ["T044"], "canonical_name": "methylselenocysteine deselenhydrase activity", "definition": "Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol. [PMID:17451884, PMID:20383543]"}
{"concept_id": "C3821326", "aliases": [], "types": ["T044"], "canonical_name": "methylselenol demethylase activity", "definition": "Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH. [PMID:17451884, PMID:17988700]"}
{"concept_id": "C3821327", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion", "definition": "The attachment of one cell to another cell via adhesion molecules. [GOC:dos]"}
{"concept_id": "C3821328", "aliases": [], "types": ["T038"], "canonical_name": "multi-organismal cell-cell adhesion"}
{"concept_id": "C3821331", "aliases": [], "types": ["T044"], "canonical_name": "methaneselenol methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide. [PMID:14705, PMID:17988700, PMID:4380351]"}
{"concept_id": "C3821332", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen selenide methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol. [PMID:14705, PMID:17988700]"}
{"concept_id": "C3821333", "aliases": [], "types": ["T044"], "canonical_name": "dimethyl selenide methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium. [PMID:17988700, PMID:3350800]"}
{"concept_id": "C3821334", "aliases": [], "types": ["T044"], "canonical_name": "selenate adenylyltransferase (ATP) activity", "definition": "Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate. [PMID:2537056]"}
{"concept_id": "C3821335", "aliases": [], "types": ["T044"], "canonical_name": "adenylylselenate kinase activity", "definition": "Catalysis of the reaction: ATP + adenylylselenate => ADP + 3'-phosphoadenylylselenate. [PMID:2537056]"}
{"concept_id": "C3821336", "aliases": [], "types": ["T044"], "canonical_name": "selenomethionine-tRNA ligase activity", "definition": "Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met). [PMID:16661668, PMID:16661782]"}
{"concept_id": "C3821337", "aliases": [], "types": ["T044"], "canonical_name": "selenocysteine-tRNA ligase activity", "definition": "Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate. [PMID:8890909, PMID:9431993, PMID:9637248]"}
{"concept_id": "C3821338", "aliases": [], "types": ["T044"], "canonical_name": "seryl-selenocysteinyl-tRNA kinase activity", "definition": "Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP. [PMID:15317934]"}
{"concept_id": "C3821339", "aliases": [], "types": ["T044"], "canonical_name": "phosphoseryl-selenocysteinyl-tRNA selenium transferase activity", "definition": "Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid. [PMID:17142313, PMID:19608919, RHEA:25041]"}
{"concept_id": "C3821340", "aliases": [], "types": ["T044"], "canonical_name": "selenodiglutathione-disulfide reductase activity", "definition": "Catalysis of the reaction: H+ + selenodiglutathione + NADPH => gluthathioselenol + glutathione + NADP+. [PMID:1569062]"}
{"concept_id": "C3821341", "aliases": [], "types": ["T044"], "canonical_name": "selenite reductase activity", "definition": "Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O. [PMID:1321713]"}
{"concept_id": "C3821342", "aliases": ["PAPSe reductase activity"], "types": ["T044"], "canonical_name": "3'-phosphoadenylylselenate reductase activity", "definition": "Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+. [PMID:14723223]"}
{"concept_id": "C3821343", "aliases": [], "types": ["T044"], "canonical_name": "methylselenol reductase activity", "definition": "Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O. [PMID:11782468]"}
{"concept_id": "C3821344", "aliases": [], "types": ["T044"], "canonical_name": "methylseleninic acid reductase activity", "definition": "Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O. [PMID:11782468]"}
{"concept_id": "C3821345", "aliases": [], "types": ["T044"], "canonical_name": "protein arginine phosphatase activity", "definition": "Catalysis of the reaction: protein arginine phosphate + H2O = protein arginine + phosphate. [PMID:23770242, RHEA:43380]"}
{"concept_id": "C3821346", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-N-phospho-arginine dephosphorylation", "definition": "The removal of phosphate residues from peptidyl-N-phospho-arginine to form peptidyl-arginine. [PMID:23770242]"}
{"concept_id": "C3821347", "aliases": [], "types": ["T043"], "canonical_name": "trans-Golgi network membrane organization", "definition": "A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane. [GOC:di, GOC:dos, PMID:23345439]"}
{"concept_id": "C3821348", "aliases": ["aggregation of single cell organisms"], "types": ["T043"], "canonical_name": "aggregation of unicellular organisms", "definition": "The clustering together of unicellular organisms in suspension form aggregates. [GOC:dos]"}
{"concept_id": "C3821349", "aliases": ["cell adhesion mediator activity", "protein binding involved in cell adhesion"], "types": ["T044"], "definition": "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell. [GOC:vw, Wikipedia:Cell_adhesion]", "canonical_name": "cell adhesion molecule"}
{"concept_id": "C3821350", "aliases": ["protein binding involved in cell-cell adhesion", "cell-cell adhesion molecule"], "types": ["T044"], "definition": "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell. [Wikipedia:Cell_adhesion]", "canonical_name": "cell-cell adhesion mediator activity"}
{"concept_id": "C3821351", "aliases": [], "types": ["T044"], "canonical_name": "collagen fibril binding", "definition": "Binding to a collagen fibril. [GOC:dos, PMID:21421911]"}
{"concept_id": "C3821352", "aliases": ["cell-matrix adhesion molecule", "cell-matrix adhesion mediator activity"], "types": ["T044"], "definition": "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix. [Wikipedia:Cell_adhesion]", "canonical_name": "protein binding involved in cell-matrix adhesion"}
{"concept_id": "C3821353", "aliases": ["protein complex location involved in cell-cell adhesion"], "types": ["T026"], "canonical_name": "protein complex involved in cell-cell adhesion", "definition": "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. [GOC:dos]"}
{"concept_id": "C3821354", "aliases": ["protein complex location involved in cell adhesion"], "types": ["T026"], "canonical_name": "protein complex involved in cell adhesion", "definition": "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. [GOC:dos]"}
{"concept_id": "C3821355", "aliases": ["cell adhesion complex location"], "types": ["T026"], "canonical_name": "cell adhesion complex"}
{"concept_id": "C3821356", "aliases": ["protein complex location involved in cell-matrix adhesion"], "types": ["T026"], "canonical_name": "protein complex involved in cell-matrix adhesion", "definition": "Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion. [GOC:dos]"}
{"concept_id": "C3821357", "aliases": [], "types": ["T044"], "canonical_name": "laminin binding involved in cell-matrix adhesion", "definition": "Any laminin protein binding that occurs as part of cell-matrix adhesion. [GOC:dos]"}
{"concept_id": "C3821358", "aliases": [], "types": ["T044"], "canonical_name": "collagen binding involved in cell-matrix adhesion", "definition": "Any collagen binding that occurs as part of cell-matrix adhesion. [GOC:dos]"}
{"concept_id": "C3821359", "aliases": [], "types": ["T044"], "canonical_name": "integrin binding involved in cell-matrix adhesion", "definition": "Any integrin binding that occurs as part of the process of cell-matrix adhesion. [GOC:dos]"}
{"concept_id": "C3821360", "aliases": [], "types": ["T044"], "canonical_name": "cadherin binding involved in cell-cell adhesion", "definition": "Any cadherin binding that occurs as part of the process of cell-cell adhesion. [GOC:dos]"}
{"concept_id": "C3821361", "aliases": [], "types": ["T026"], "canonical_name": "network-forming collagen trimer", "definition": "A collagen trimer that forms networks. [PMID:21421911]"}
{"concept_id": "C3821362", "aliases": ["Supramolecular collagen assembly", "complex location of collagen trimers", "Supramolecular aggregate of collagen"], "types": ["T026"], "canonical_name": "complex of collagen trimers", "definition": "A complex of collagen trimers such as a fibril or collagen network. [GOC:dos]"}
{"concept_id": "C3821363", "aliases": [], "types": ["T026"], "canonical_name": "collagen network", "definition": "A supramolecular complex that consists of collagen triple helices associated to form a network. [GOC:dos, PMID:21421911]"}
{"concept_id": "C3821364", "aliases": ["collagen hexagonal network"], "types": ["T026"], "canonical_name": "collagen sheet", "definition": "A protein complex that consists of collagen triple helices associated to form a sheet-like network. [GOC:dos, PMID:21421911]"}
{"concept_id": "C3821365", "aliases": [], "types": ["T026"], "canonical_name": "collagen beaded filament", "definition": "A supramolecular assembly of collagen trimers with a 'beads on a string'-like structure. [GOC:dos, PMID:19693541]"}
{"concept_id": "C3821366", "aliases": [], "types": ["T026"], "canonical_name": "beads on a string"}
{"concept_id": "C3821367", "aliases": [], "types": ["T024"], "canonical_name": "collagen anchoring fibril", "definition": "A specialised collagen fibril that functions as an anchor, binding to other collagen structures. [GOC:dos]"}
{"concept_id": "C3821368", "aliases": [], "types": ["T038"], "canonical_name": "regulation of action potential", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]"}
{"concept_id": "C3821369", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cardiac muscle cell action potential", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:dos, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3821370", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane depolarization during action potential", "definition": "Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential. [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8]"}
{"concept_id": "C3821371", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane repolarization during action potential", "definition": "Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential. [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8]"}
{"concept_id": "C3821372", "aliases": ["regulation of atrioventricular node cardiac muscle cell action potential", "regulation of AV node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "regulation of AV node cell action potential", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3821373", "aliases": ["regulation of bundle of His cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "regulation of bundle of His cell action potential", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3821374", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Purkinje myocyte action potential", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3821375", "aliases": ["regulation of sinoatrial node cardiac muscle cell action potential", "regulation of SAN cardiac muscle cell action potential", "regulation of SA node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "regulation of SA node cell action potential", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3821376", "aliases": [], "types": ["T040"], "canonical_name": "regulation of neuronal action potential", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:dph, GOC:isa_complete, GOC:tb]"}
{"concept_id": "C3821377", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cardiac muscle cell action potential involved in regulation of contraction", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3821378", "aliases": [], "types": ["T043"], "canonical_name": "regulation of atrial cardiac muscle cell action potential", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3821379", "aliases": [], "types": ["T038"], "canonical_name": "regulation of ventricular cardiac muscle cell action potential", "definition": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C3821380", "aliases": [], "types": ["T043"], "canonical_name": "membrane repolarization during atrial cardiac muscle cell action potential", "definition": "The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]"}
{"concept_id": "C3821381", "aliases": [], "types": ["T043"], "canonical_name": "membrane repolarization during ventricular cardiac muscle cell action potential", "definition": "The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]"}
{"concept_id": "C3821382", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of membrane depolarization during cardiac muscle cell action potential"}
{"concept_id": "C3821383", "aliases": [], "types": ["T039"], "canonical_name": "activation of membrane depolarization during cardiac muscle cell action potential"}
{"concept_id": "C3821384", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3821385", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]"}
{"concept_id": "C3821386", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of non-canonical Wnt-activated signaling pathway via JNK cascade"}
{"concept_id": "C3821387", "aliases": ["neosartoricin metabolism"], "types": ["T044"], "canonical_name": "neosartoricin metabolic process", "definition": "The chemical reactions and pathways involving neosartoricin. [GOC:di, GOC:TermGenie, PMID:23368997]"}
{"concept_id": "C3821388", "aliases": ["neosartoricin degradation", "neosartoricin breakdown", "neosartoricin catabolism"], "types": ["T044"], "canonical_name": "neosartoricin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of neosartoricin. [GOC:di, GOC:TermGenie, PMID:23368997]"}
{"concept_id": "C3821389", "aliases": ["neosartoricin biosynthesis", "neosartoricin synthesis", "neosartoricin anabolism", "neosartoricin formation"], "types": ["T044"], "canonical_name": "neosartoricin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of neosartoricin. [GOC:di, GOC:TermGenie, PMID:23368997]"}
{"concept_id": "C3821390", "aliases": [], "types": ["T044"], "canonical_name": "(25S)-Delta(4)-dafachronate binding", "definition": "Binding to (25S)-Delta(4)-dafachronate. [GOC:TermGenie, PMID:16529801]"}
{"concept_id": "C3821391", "aliases": [], "types": ["T044"], "canonical_name": "(25S)-Delta(7)-dafachronate binding", "definition": "Binding to (25S)-Delta(7)-dafachronate. [GOC:TermGenie, PMID:16529801]"}
{"concept_id": "C3821392", "aliases": ["regulation of neosartoricin synthesis", "regulation of neosartoricin formation", "regulation of neosartoricin anabolism", "regulation of neosartoricin biosynthesis"], "types": ["T044"], "canonical_name": "regulation of neosartoricin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of neosartoricin biosynthetic process. [GOC:di, GOC:TermGenie, PMID:23368997]"}
{"concept_id": "C3821393", "aliases": ["down-regulation of neosartoricin biosynthetic process", "downregulation of neosartoricin anabolism", "negative regulation of neosartoricin anabolism", "down-regulation of neosartoricin synthesis", "downregulation of neosartoricin biosynthesis", "negative regulation of neosartoricin synthesis", "down regulation of neosartoricin biosynthetic process", "downregulation of neosartoricin formation", "inhibition of neosartoricin biosynthesis", "inhibition of neosartoricin formation", "inhibition of neosartoricin synthesis", "inhibition of neosartoricin anabolism", "negative regulation of neosartoricin formation", "down regulation of neosartoricin formation", "down-regulation of neosartoricin formation", "downregulation of neosartoricin synthesis", "downregulation of neosartoricin biosynthetic process", "down regulation of neosartoricin biosynthesis", "down regulation of neosartoricin synthesis", "down regulation of neosartoricin anabolism", "down-regulation of neosartoricin biosynthesis", "down-regulation of neosartoricin anabolism", "negative regulation of neosartoricin biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of neosartoricin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neosartoricin biosynthetic process. [GOC:di, GOC:TermGenie, PMID:23368997]"}
{"concept_id": "C3821394", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of neosartoricin biosynthetic process"}
{"concept_id": "C3821395", "aliases": ["activation of neosartoricin anabolism", "upregulation of neosartoricin formation", "upregulation of neosartoricin anabolism", "up-regulation of neosartoricin synthesis", "up-regulation of neosartoricin biosynthesis", "up regulation of neosartoricin formation", "positive regulation of neosartoricin anabolism", "up-regulation of neosartoricin formation", "upregulation of neosartoricin biosynthetic process", "up regulation of neosartoricin synthesis", "up regulation of neosartoricin biosynthesis", "activation of neosartoricin biosynthesis", "upregulation of neosartoricin biosynthesis", "up regulation of neosartoricin biosynthetic process", "up-regulation of neosartoricin anabolism", "positive regulation of neosartoricin biosynthesis", "positive regulation of neosartoricin formation", "up-regulation of neosartoricin biosynthetic process", "activation of neosartoricin synthesis", "activation of neosartoricin biosynthetic process", "positive regulation of neosartoricin synthesis", "activation of neosartoricin formation", "up regulation of neosartoricin anabolism", "upregulation of neosartoricin synthesis"], "types": ["T044"], "canonical_name": "positive regulation of neosartoricin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of neosartoricin biosynthetic process. [GOC:di, GOC:TermGenie, PMID:23368997]"}
{"concept_id": "C3821396", "aliases": ["(25S)-Delta(7)-dafachronate metabolism"], "types": ["T044"], "canonical_name": "(25S)-Delta(7)-dafachronate metabolic process", "definition": "The chemical reactions and pathways involving (25S)-Delta(7)-dafachronate. [GOC:TermGenie, PMID:22505847]"}
{"concept_id": "C3821397", "aliases": ["(25S)-Delta(4)-dafachronate metabolism"], "types": ["T044"], "canonical_name": "(25S)-Delta(4)-dafachronate metabolic process", "definition": "The chemical reactions and pathways involving (25S)-Delta(4)-dafachronate. [GOC:TermGenie, PMID:20178781]"}
{"concept_id": "C3821398", "aliases": ["down regulation of perfect stage fruiting body development", "down regulation of fruiting body formation involved in sexual reproduction", "downregulation of sporocarp development involved in sexual reproduction", "negative regulation of perfect stage fruiting body development", "down-regulation of perfect stage fruiting body development", "down-regulation of fruiting body development involved in sexual reproduction", "downregulation of fruiting body development involved in sexual reproduction", "downregulation of perfect stage fruiting body development", "down regulation of fruiting body development involved in sexual reproduction", "down-regulation of sporocarp development involved in sexual reproduction", "downregulation of ascus development", "down-regulation of fruiting body formation involved in sexual reproduction", "downregulation of fruiting body formation involved in sexual reproduction", "down-regulation of ascus development", "down regulation of sporocarp development involved in sexual reproduction", "down regulation of ascus development"], "types": ["T043"], "canonical_name": "negative regulation of sporocarp development involved in sexual reproduction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sporocarp development involved in sexual reproduction. [GOC:di, GOC:TermGenie, PMID:23480775]"}
{"concept_id": "C3821399", "aliases": ["inhibition of perfect stage fruiting body development", "inhibition of sporocarp development involved in sexual reproduction", "inhibition of fruiting body development involved in sexual reproduction", "inhibition of fruiting body formation involved in sexual reproduction"], "types": ["T043"], "canonical_name": "inhibition of ascus development"}
{"concept_id": "C3821400", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of fruiting body development involved in sexual reproduction"}
{"concept_id": "C3821401", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of fruiting body formation involved in sexual reproduction"}
{"concept_id": "C3821402", "aliases": ["upregulation of sporocarp development involved in sexual reproduction", "up regulation of sporocarp development involved in sexual reproduction", "up-regulation of sporocarp development involved in sexual reproduction"], "types": ["T043"], "canonical_name": "positive regulation of sporocarp development involved in sexual reproduction", "definition": "Any process that activates or increases the frequency, rate or extent of sporocarp development involved in sexual reproduction. [GOC:di, GOC:TermGenie, PMID:23480775]"}
{"concept_id": "C3821403", "aliases": ["activation of perfect stage fruiting body development", "activation of fruiting body formation involved in sexual reproduction", "activation of fruiting body development involved in sexual reproduction", "activation of sporocarp development involved in sexual reproduction"], "types": ["T043"], "canonical_name": "activation of ascus development"}
{"concept_id": "C3821404", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of fruiting body development involved in sexual reproduction"}
{"concept_id": "C3821405", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of fruiting body formation involved in sexual reproduction"}
{"concept_id": "C3821406", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of perfect stage fruiting body development"}
{"concept_id": "C3821407", "aliases": ["up-regulation of ascus development"], "types": ["T043"], "canonical_name": "up regulation of ascus development"}
{"concept_id": "C3821408", "aliases": ["up-regulation of fruiting body development involved in sexual reproduction"], "types": ["T043"], "canonical_name": "up regulation of fruiting body development involved in sexual reproduction"}
{"concept_id": "C3821409", "aliases": ["up-regulation of fruiting body formation involved in sexual reproduction"], "types": ["T043"], "canonical_name": "up regulation of fruiting body formation involved in sexual reproduction"}
{"concept_id": "C3821410", "aliases": ["up-regulation of perfect stage fruiting body development"], "types": ["T043"], "canonical_name": "up regulation of perfect stage fruiting body development"}
{"concept_id": "C3821411", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of ascus development"}
{"concept_id": "C3821412", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of fruiting body development involved in sexual reproduction"}
{"concept_id": "C3821413", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of fruiting body formation involved in sexual reproduction"}
{"concept_id": "C3821414", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of perfect stage fruiting body development"}
{"concept_id": "C3821415", "aliases": ["betaine aldehyde metabolism"], "types": ["T044"], "canonical_name": "betaine aldehyde metabolic process", "definition": "The chemical reactions and pathways involving betaine aldehyde. [GOC:di, GOC:TermGenie, PMID:23563483]"}
{"concept_id": "C3821416", "aliases": ["betaine aldehyde breakdown", "betaine aldehyde degradation", "betaine aldehyde catabolism"], "types": ["T044"], "canonical_name": "betaine aldehyde catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of betaine aldehyde. [GOC:di, GOC:TermGenie, PMID:23563483]"}
{"concept_id": "C3821417", "aliases": ["betaine aldehyde synthesis", "betaine aldehyde formation", "betaine aldehyde anabolism", "betaine aldehyde biosynthesis"], "types": ["T044"], "canonical_name": "betaine aldehyde biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of betaine aldehyde. [GOC:di, GOC:TermGenie, PMID:23563483]"}
{"concept_id": "C3821424", "aliases": [], "types": ["T040"], "canonical_name": "response to L-glutamate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus. [GOC:TermGenie, PMID:23574009]"}
{"concept_id": "C3821425", "aliases": ["regulation of cellulose and pectin-containing cell wall pectin metabolic process", "regulation of pectin metabolism during cell wall biogenesis", "regulation of plant-type cell wall pectin metabolic process", "regulation of cell wall pectin metabolism"], "types": ["T043"], "canonical_name": "regulation of cell wall pectin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of cell wall pectin metabolic process. [GOC:TermGenie, PMID:23453954]"}
{"concept_id": "C3821428", "aliases": [], "types": ["T044"], "canonical_name": "regulation of sphingolipid mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of sphingolipid signaling. [GOC:TermGenie, PMID:20870412]"}
{"concept_id": "C3821429", "aliases": [], "types": ["T044"], "canonical_name": "regulation of sphingolipid signaling pathway"}
{"concept_id": "C3821430", "aliases": ["down-regulation of sphingolipid mediated signaling pathway", "down regulation of sphingolipid mediated signaling pathway", "downregulation of sphingolipid mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of sphingolipid mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sphingolipid signaling. [GOC:TermGenie, PMID:20870412]"}
{"concept_id": "C3821431", "aliases": ["down-regulation of sphingolipid signaling pathway"], "types": ["T044"], "canonical_name": "down regulation of sphingolipid signaling pathway"}
{"concept_id": "C3821432", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of sphingolipid signaling pathway"}
{"concept_id": "C3821433", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sphingolipid mediated signaling pathway"}
{"concept_id": "C3821434", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sphingolipid signaling pathway"}
{"concept_id": "C3821435", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of sphingolipid signaling pathway"}
{"concept_id": "C3821436", "aliases": ["up regulation of sphingolipid mediated signaling pathway", "up-regulation of sphingolipid signaling pathway", "up-regulation of sphingolipid mediated signaling pathway", "upregulation of sphingolipid mediated signaling pathway", "up regulation of sphingolipid signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of sphingolipid mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of sphingolipid signaling. [GOC:TermGenie, PMID:20870412]"}
{"concept_id": "C3821437", "aliases": [], "types": ["T044"], "canonical_name": "activation of sphingolipid mediated signaling pathway"}
{"concept_id": "C3821438", "aliases": [], "types": ["T044"], "canonical_name": "activation of sphingolipid signaling pathway"}
{"concept_id": "C3821439", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of sphingolipid signaling pathway"}
{"concept_id": "C3821440", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of sphingolipid signaling pathway"}
{"concept_id": "C3821441", "aliases": ["regulation of HIF1alpha pathway", "regulation of hypoxia-inducible factor-1alpha signalling pathway"], "types": ["T044"], "canonical_name": "regulation of hypoxia-inducible factor-1alpha signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3821442", "aliases": ["inhibition of hypoxia-inducible factor-1alpha signaling pathway", "negative regulation of HIF1alpha pathway", "downregulation of HIF1alpha pathway", "negative regulation of hypoxia-inducible factor-1alpha signalling pathway", "downregulation of hypoxia-inducible factor-1alpha signalling pathway", "down regulation of HIF1alpha pathway", "down-regulation of HIF1alpha pathway", "inhibition of HIF1alpha pathway", "down regulation of hypoxia-inducible factor-1alpha signalling pathway", "down-regulation of hypoxia-inducible factor-1alpha signaling pathway", "down-regulation of hypoxia-inducible factor-1alpha signalling pathway", "down regulation of hypoxia-inducible factor-1alpha signaling pathway", "inhibition of hypoxia-inducible factor-1alpha signalling pathway", "downregulation of hypoxia-inducible factor-1alpha signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of hypoxia-inducible factor-1alpha signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3821443", "aliases": ["upregulation of hypoxia-inducible factor-1alpha signalling pathway", "positive regulation of HIF1alpha pathway", "upregulation of HIF1alpha pathway", "up-regulation of HIF1alpha pathway", "upregulation of hypoxia-inducible factor-1alpha signaling pathway", "positive regulation of hypoxia-inducible factor-1alpha signalling pathway", "up regulation of hypoxia-inducible factor-1alpha signalling pathway", "up-regulation of hypoxia-inducible factor-1alpha signaling pathway", "up regulation of HIF1alpha pathway", "up regulation of hypoxia-inducible factor-1alpha signaling pathway", "up-regulation of hypoxia-inducible factor-1alpha signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of hypoxia-inducible factor-1alpha signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway. [GOC:bf, GOC:TermGenie, PMID:21685248]"}
{"concept_id": "C3821444", "aliases": ["activation of hypoxia-inducible factor-1alpha signalling pathway", "activation of HIF1alpha pathway"], "types": ["T044"], "canonical_name": "activation of hypoxia-inducible factor-1alpha signaling pathway"}
{"concept_id": "C3821445", "aliases": [], "types": ["T044"], "canonical_name": "hypoxic stabilization of HIF1A"}
{"concept_id": "C3821446", "aliases": [], "types": ["T043"], "canonical_name": "response to salt", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. [GOC:mls, GOC:TermGenie, PMID:16666921]"}
{"concept_id": "C3821447", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to salt", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. [GOC:mls, GOC:TermGenie, PMID:16666921]"}
{"concept_id": "C3821448", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lateral motor column neuron migration", "definition": "Any process that modulates the frequency, rate or extent of lateral motor column neuron migration. [GOC:TermGenie, GOC:yaf, PMID:20711475]"}
{"concept_id": "C3821449", "aliases": ["downregulation of lateral motor column neuron migration", "down-regulation of lateral motor column neuron migration", "down regulation of lateral motor column neuron migration"], "types": ["T043"], "canonical_name": "negative regulation of lateral motor column neuron migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lateral motor column neuron migration. [GOC:TermGenie, GOC:yaf, PMID:20711475]"}
{"concept_id": "C3821450", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lateral motor column neuron migration"}
{"concept_id": "C3821451", "aliases": ["upregulation of lateral motor column neuron migration", "up-regulation of lateral motor column neuron migration", "up regulation of lateral motor column neuron migration"], "types": ["T043"], "canonical_name": "positive regulation of lateral motor column neuron migration", "definition": "Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration. [GOC:TermGenie, GOC:yaf, PMID:20711475]"}
{"concept_id": "C3821452", "aliases": [], "types": ["T043"], "canonical_name": "activation of lateral motor column neuron migration"}
{"concept_id": "C3821453", "aliases": ["D-valine degradation", "D-valine breakdown", "D-valine catabolism"], "types": ["T044"], "canonical_name": "D-valine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of D-valine. [GOC:TermGenie, PMID:23085840]"}
{"concept_id": "C3821454", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium ion import into sarcoplasmic reticulum", "definition": "Any process that modulates the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590]"}
{"concept_id": "C3821455", "aliases": ["down-regulation of calcium ion import into sarcoplasmic reticulum", "down regulation of calcium ion import into sarcoplasmic reticulum", "downregulation of calcium ion import into sarcoplasmic reticulum"], "types": ["T043"], "canonical_name": "negative regulation of calcium ion import into sarcoplasmic reticulum", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590]"}
{"concept_id": "C3821456", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcium ion import into sarcoplasmic reticulum"}
{"concept_id": "C3821457", "aliases": ["up-regulation of calcium ion import into sarcoplasmic reticulum", "upregulation of calcium ion import into sarcoplasmic reticulum", "up regulation of calcium ion import into sarcoplasmic reticulum"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion import into sarcoplasmic reticulum", "definition": "Any process that activates or increases the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590]"}
{"concept_id": "C3821458", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium ion import into sarcoplasmic reticulum"}
{"concept_id": "C3821459", "aliases": ["down regulation of protein S-nitrosylation", "downregulation of protein S-nitrosylation", "downregulation of peptidyl-cysteine S-nitrosylation", "down-regulation of S-nitrosylation", "inhibition of S-nitrosylation", "down regulation of peptidyl-cysteine S-nitrosylation", "negative regulation of S-nitrosylation", "down-regulation of protein S-nitrosylation", "down regulation of S-nitrosylation", "down-regulation of peptidyl-cysteine S-nitrosylation", "downregulation of S-nitrosylation", "negative regulation of protein S-nitrosylation", "inhibition of protein S-nitrosylation"], "types": ["T044"], "canonical_name": "negative regulation of peptidyl-cysteine S-nitrosylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19198614]"}
{"concept_id": "C3821460", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptidyl-cysteine S-nitrosylation"}
{"concept_id": "C3821461", "aliases": ["fumagillin metabolism"], "types": ["T044"], "canonical_name": "fumagillin metabolic process", "definition": "The chemical reactions and pathways involving fumagillin. [GOC:di, GOC:TermGenie, PMID:23488861]"}
{"concept_id": "C3821462", "aliases": ["fumagillin degradation", "fumagillin breakdown", "fumagillin catabolism"], "types": ["T044"], "canonical_name": "fumagillin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fumagillin. [GOC:di, GOC:TermGenie, PMID:23488861]"}
{"concept_id": "C3821463", "aliases": ["fumagillin synthesis", "fumagillin formation", "fumagillin anabolism", "fumagillin biosynthesis"], "types": ["T044"], "canonical_name": "fumagillin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumagillin. [GOC:di, GOC:TermGenie, PMID:23488861]"}
{"concept_id": "C3821464", "aliases": ["S,S-dimethyl-beta-propiothetin catabolism", "S,S-dimethyl-beta-propiothetin degradation", "S,S-dimethyl-beta-propiothetin catabolic process", "S,S-dimethyl-beta-propiothetin breakdown"], "types": ["T044"], "canonical_name": "dimethylsulfoniopropionate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of S,S-dimethyl-beta-propiothetin. [GOC:jh2, GOC:TermGenie, PMID:19807777]"}
{"concept_id": "C3821465", "aliases": ["cellulose and pectin-containing cell wall loosening involved in abscission"], "types": ["T043"], "canonical_name": "plant-type cell wall loosening involved in abscission", "definition": "Any plant-type cell wall loosening that is involved in abscission. [GOC:TermGenie, PMID:23479623]"}
{"concept_id": "C3821466", "aliases": ["cell wall polysaccharide breakdown involved in lateral root development"], "types": ["T043"], "canonical_name": "cell wall polysaccharide catabolic process involved in lateral root development", "definition": "Any cell wall polysaccharide catabolic process that is involved in lateral root development. [GOC:TermGenie, PMID:23479623]"}
{"concept_id": "C3821467", "aliases": ["regulation of fumagillin biosynthesis", "regulation of fumagillin formation", "regulation of fumagillin anabolism", "regulation of fumagillin synthesis"], "types": ["T044"], "canonical_name": "regulation of fumagillin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of fumagillin biosynthetic process. [GOC:di, GOC:TermGenie, PMID:23488861]"}
{"concept_id": "C3821468", "aliases": ["down regulation of fumagillin biosynthesis", "down regulation of fumagillin formation", "down-regulation of fumagillin formation", "inhibition of fumagillin formation", "inhibition of fumagillin synthesis", "downregulation of fumagillin anabolism", "inhibition of fumagillin anabolism", "negative regulation of fumagillin formation", "down regulation of fumagillin synthesis", "downregulation of fumagillin synthesis", "inhibition of fumagillin biosynthesis", "downregulation of fumagillin formation", "down-regulation of fumagillin synthesis", "negative regulation of fumagillin biosynthesis", "downregulation of fumagillin biosynthesis", "down-regulation of fumagillin biosynthetic process", "down regulation of fumagillin biosynthetic process", "down-regulation of fumagillin biosynthesis", "negative regulation of fumagillin synthesis", "negative regulation of fumagillin anabolism", "down regulation of fumagillin anabolism", "downregulation of fumagillin biosynthetic process", "down-regulation of fumagillin anabolism"], "types": ["T044"], "canonical_name": "negative regulation of fumagillin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fumagillin biosynthetic process. [GOC:di, GOC:TermGenie, PMID:23488861]"}
{"concept_id": "C3821469", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of fumagillin biosynthetic process"}
{"concept_id": "C3821470", "aliases": ["positive regulation of fumagillin anabolism", "up-regulation of fumagillin biosynthetic process", "upregulation of fumagillin biosynthesis", "activation of fumagillin biosynthesis", "positive regulation of fumagillin biosynthesis", "upregulation of fumagillin synthesis", "up regulation of fumagillin anabolism", "activation of fumagillin synthesis", "up-regulation of fumagillin synthesis", "up regulation of fumagillin biosynthesis", "up-regulation of fumagillin formation", "upregulation of fumagillin anabolism", "up-regulation of fumagillin anabolism", "up regulation of fumagillin synthesis", "up-regulation of fumagillin biosynthesis", "positive regulation of fumagillin formation", "upregulation of fumagillin formation", "positive regulation of fumagillin synthesis", "upregulation of fumagillin biosynthetic process", "up regulation of fumagillin biosynthetic process", "activation of fumagillin anabolism", "up regulation of fumagillin formation", "activation of fumagillin formation"], "types": ["T044"], "canonical_name": "positive regulation of fumagillin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of fumagillin biosynthetic process. [GOC:di, GOC:TermGenie, PMID:23488861]"}
{"concept_id": "C3821471", "aliases": [], "types": ["T044"], "canonical_name": "activation of fumagillin biosynthetic process"}
{"concept_id": "C3821472", "aliases": ["positive regulation of sperm movement", "up-regulation of sperm motility", "up-regulation of sperm movement", "up regulation of sperm motility", "upregulation of sperm movement", "up regulation of sperm movement", "upregulation of sperm motility", "activation of sperm movement"], "types": ["T043"], "canonical_name": "positive regulation of sperm motility"}
{"concept_id": "C3821473", "aliases": [], "types": ["T043"], "canonical_name": "activation of sperm motility"}
{"concept_id": "C3821477", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of cartilage homeostasis"}
{"concept_id": "C3821479", "aliases": ["up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium", "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacteria", "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacterium", "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria", "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium", "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria", "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria", "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacteria", "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacterium", "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria", "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria", "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium", "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium", "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium", "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria", "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacterium", "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacterium", "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacteria", "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium", "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacteria", "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium", "definition": "Any positive regulation of transcription from RNA polymerase II promoter that is involved in defense response to Gram-negative bacterium. [GOC:kmv, GOC:TermGenie, PMID:17183709]"}
{"concept_id": "C3821480", "aliases": ["activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium", "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria"], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria"}
{"concept_id": "C3821481", "aliases": ["activation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821482", "aliases": ["activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium"], "types": ["T045"], "canonical_name": "activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria"}
{"concept_id": "C3821483", "aliases": ["positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium", "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria"], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria"}
{"concept_id": "C3821484", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821485", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of global transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821486", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821487", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821488", "aliases": ["stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium"], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria"}
{"concept_id": "C3821489", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821490", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821491", "aliases": ["up-regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"], "types": ["T045"], "canonical_name": "up regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821492", "aliases": ["up-regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"], "types": ["T045"], "canonical_name": "up regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821493", "aliases": ["upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium", "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria", "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium"], "types": ["T045"], "canonical_name": "upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria"}
{"concept_id": "C3821494", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821495", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3821496", "aliases": ["hormonally active vitamin D3 binding", "1alpha,25-dihydroxycholecalciferol binding", "1,25-dihydroxycholecalciferol binding", "1alpha,25(OH)2 vitamin D3 binding", "1,25-dihydroxyvitamin D3 binding", "1alpha,25-dihydroxyvitamin D3 binding", "1alpha,25(OH)2D3 binding"], "types": ["T044"], "canonical_name": "calcitriol binding", "definition": "Binding to calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3. [GOC:TermGenie, PMID:21872797, Wikipedia:Calcitriol_receptor]"}
{"concept_id": "C3821497", "aliases": [], "types": ["T043"], "canonical_name": "regulation of metaphase/anaphase transition of cell cycle", "definition": "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821498", "aliases": ["down regulation of metaphase/anaphase transition of cell cycle", "down-regulation of metaphase/anaphase transition of cell cycle", "downregulation of metaphase/anaphase transition of cell cycle"], "types": ["T043"], "canonical_name": "negative regulation of metaphase/anaphase transition of cell cycle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821499", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of metaphase/anaphase transition of cell cycle"}
{"concept_id": "C3821500", "aliases": ["up-regulation of metaphase/anaphase transition of cell cycle", "upregulation of metaphase/anaphase transition of cell cycle", "up regulation of metaphase/anaphase transition of cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of metaphase/anaphase transition of cell cycle", "definition": "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821501", "aliases": [], "types": ["T043"], "canonical_name": "activation of metaphase/anaphase transition of cell cycle"}
{"concept_id": "C3821502", "aliases": ["regulation of meiotic metaphase/anaphase transition"], "types": ["T044"], "canonical_name": "regulation of metaphase/anaphase transition of meiotic cell cycle", "definition": "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821503", "aliases": ["down-regulation of meiotic metaphase/anaphase transition", "downregulation of meiotic metaphase/anaphase transition", "inhibition of metaphase/anaphase transition of meiotic cell cycle", "negative regulation of meiotic metaphase/anaphase transition", "downregulation of metaphase/anaphase transition of meiotic cell cycle", "down-regulation of metaphase/anaphase transition of meiotic cell cycle", "inhibition of meiotic metaphase/anaphase transition", "down regulation of meiotic metaphase/anaphase transition", "down regulation of metaphase/anaphase transition of meiotic cell cycle"], "types": ["T043"], "canonical_name": "negative regulation of metaphase/anaphase transition of meiotic cell cycle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821504", "aliases": ["upregulation of meiotic metaphase/anaphase transition", "up-regulation of meiotic metaphase/anaphase transition", "up-regulation of metaphase/anaphase transition of meiotic cell cycle", "upregulation of metaphase/anaphase transition of meiotic cell cycle", "up regulation of meiotic metaphase/anaphase transition", "positive regulation of meiotic metaphase/anaphase transition", "activation of meiotic metaphase/anaphase transition", "up regulation of metaphase/anaphase transition of meiotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of metaphase/anaphase transition of meiotic cell cycle", "definition": "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821505", "aliases": [], "types": ["T043"], "canonical_name": "activation of metaphase/anaphase transition of meiotic cell cycle"}
{"concept_id": "C3821506", "aliases": ["regulation of leucocyte differentiation", "regulation of immune cell differentiation"], "types": ["T038"], "canonical_name": "regulation of leukocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of leukocyte differentiation. [GOC:add, GOC:TermGenie]"}
{"concept_id": "C3821507", "aliases": ["down regulation of leucocyte differentiation", "negative regulation of immune cell differentiation", "down-regulation of leukocyte differentiation", "down regulation of immune cell differentiation", "negative regulation of leucocyte differentiation", "downregulation of immune cell differentiation", "down regulation of leukocyte differentiation", "down-regulation of leucocyte differentiation", "inhibition of leucocyte differentiation", "downregulation of leukocyte differentiation", "inhibition of leukocyte differentiation", "down-regulation of immune cell differentiation", "downregulation of leucocyte differentiation"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. [GOC:add, GOC:TermGenie]"}
{"concept_id": "C3821508", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of immune cell differentiation"}
{"concept_id": "C3821509", "aliases": ["up regulation of leucocyte differentiation", "positive regulation of leucocyte differentiation", "up regulation of leukocyte differentiation", "up-regulation of leucocyte differentiation", "upregulation of leucocyte differentiation", "up-regulation of immune cell differentiation", "upregulation of leukocyte differentiation", "up-regulation of leukocyte differentiation", "upregulation of immune cell differentiation", "up regulation of immune cell differentiation", "positive regulation of immune cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. [GOC:add, GOC:TermGenie]"}
{"concept_id": "C3821510", "aliases": [], "types": ["T043"], "canonical_name": "activation of immune cell differentiation"}
{"concept_id": "C3821511", "aliases": ["activation of leukocyte differentiation"], "types": ["T043"], "canonical_name": "activation of leucocyte differentiation"}
{"concept_id": "C3821512", "aliases": ["regulation of transport across mitochondrial membrane involved in apoptotic process", "regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death", "regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis", "regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death", "regulation of mitochondrial membrane permeability involved in apoptotic cell death", "regulation of transport across mitochondrial membrane involved in apoptotic cell death", "regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis"], "types": ["T043"], "canonical_name": "regulation of mitochondrial membrane permeability involved in apoptotic process", "definition": "Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]"}
{"concept_id": "C3821513", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial membrane permeability involved in apoptosis"}
{"concept_id": "C3821514", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial membrane permeability involved in apoptotic program"}
{"concept_id": "C3821515", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821516", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial membrane permeability involved in type I programmed cell death"}
{"concept_id": "C3821517", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transport across mitochondrial membrane involved in apoptosis"}
{"concept_id": "C3821518", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transport across mitochondrial membrane involved in apoptotic program"}
{"concept_id": "C3821519", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821520", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transport across mitochondrial membrane involved in type I programmed cell death"}
{"concept_id": "C3821521", "aliases": ["negative regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death", "negative regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death", "negative regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis", "negative regulation of mitochondrial membrane permeability involved in apoptotic cell death", "negative regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis", "negative regulation of transport across mitochondrial membrane involved in apoptotic process", "negative regulation of transport across mitochondrial membrane involved in apoptotic cell death"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial membrane permeability involved in apoptotic process", "definition": "Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process. [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]"}
{"concept_id": "C3821522", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeability involved in apoptosis"}
{"concept_id": "C3821523", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeability involved in apoptotic cell death"}
{"concept_id": "C3821524", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeability involved in apoptotic process"}
{"concept_id": "C3821525", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeability involved in apoptotic program"}
{"concept_id": "C3821526", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeability involved in apoptotic programmed cell death"}
{"concept_id": "C3821527", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeability involved in programmed cell death by apoptosis"}
{"concept_id": "C3821528", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeability involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821529", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeability involved in type I programmed cell death"}
{"concept_id": "C3821530", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeabilization involved in apoptosis"}
{"concept_id": "C3821531", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeabilization involved in apoptotic cell death"}
{"concept_id": "C3821532", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeabilization involved in apoptotic process"}
{"concept_id": "C3821533", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeabilization involved in apoptotic program"}
{"concept_id": "C3821534", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeabilization involved in apoptotic programmed cell death"}
{"concept_id": "C3821535", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeabilization involved in programmed cell death by apoptosis"}
{"concept_id": "C3821536", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeabilization involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821537", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane impermeabilization involved in type I programmed cell death"}
{"concept_id": "C3821538", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial membrane permeability involved in apoptosis"}
{"concept_id": "C3821539", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial membrane permeability involved in apoptotic program"}
{"concept_id": "C3821540", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821541", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial membrane permeability involved in type I programmed cell death"}
{"concept_id": "C3821542", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of transport across mitochondrial membrane involved in apoptosis"}
{"concept_id": "C3821543", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of transport across mitochondrial membrane involved in apoptotic program"}
{"concept_id": "C3821544", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821545", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of transport across mitochondrial membrane involved in type I programmed cell death"}
{"concept_id": "C3821546", "aliases": ["positive regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity", "positive regulation of mitochondrial membrane permeability involved in apoptotic cell death", "positive regulation of transport across mitochondrial membrane involved in apoptotic cell death", "positive regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis", "positive regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death", "positive regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis", "positive regulation of transport across mitochondrial membrane involved in apoptotic process", "positive regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane permeability involved in apoptotic process", "definition": "Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process. [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]"}
{"concept_id": "C3821547", "aliases": ["mitochondrial membrane permeability transition involved in apoptotic cell death", "mitochondrial permeability transition involved in apoptosis", "mitochondrial membrane permeability transition involved in apoptotic programmed cell death", "mitochondrial membrane permeability transition involved in programmed cell death by apoptosis", "mitochondrial membrane permeability transition involved in apoptotic process", "mitochondrial membrane permeability transition involved in apoptotic program"], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in apoptosis"}
{"concept_id": "C3821548", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821549", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in type I programmed cell death"}
{"concept_id": "C3821550", "aliases": ["mitochondrial membrane permeabilization involved in apoptotic program", "mitochondrial membrane permeabilization involved in apoptotic process", "mitochondrial membrane permeabilization involved in apoptotic cell death"], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in apoptosis"}
{"concept_id": "C3821551", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in apoptotic programmed cell death"}
{"concept_id": "C3821552", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in programmed cell death by apoptosis"}
{"concept_id": "C3821553", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821554", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in type I programmed cell death"}
{"concept_id": "C3821555", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in apoptotic cell death"}
{"concept_id": "C3821556", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in apoptotic process"}
{"concept_id": "C3821557", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in apoptotic program"}
{"concept_id": "C3821558", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in apoptotic programmed cell death"}
{"concept_id": "C3821559", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in programmed cell death by apoptosis"}
{"concept_id": "C3821560", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821561", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in type I programmed cell death"}
{"concept_id": "C3821562", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane permeability involved in apoptosis"}
{"concept_id": "C3821563", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane permeability involved in apoptotic program"}
{"concept_id": "C3821564", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane permeability involved in type I programmed cell death"}
{"concept_id": "C3821565", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across mitochondrial membrane involved in apoptosis"}
{"concept_id": "C3821566", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across mitochondrial membrane involved in apoptotic program"}
{"concept_id": "C3821567", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821568", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across mitochondrial membrane involved in type I programmed cell death"}
{"concept_id": "C3821569", "aliases": [], "types": ["T043"], "canonical_name": "response to diethyl maleate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus. [GOC:TermGenie, PMID:12100563]"}
{"concept_id": "C3821570", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to diethyl maleate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus. [GOC:TermGenie, PMID:12100563]"}
{"concept_id": "C3821571", "aliases": [], "types": ["T044"], "canonical_name": "nucleotide phosphorylation involved in DNA repair", "definition": "Any nucleotide phosphorylation that is involved in DNA repair. [GOC:TermGenie, PMID:11729194]"}
{"concept_id": "C3821572", "aliases": ["D-valine metabolism"], "types": ["T044"], "canonical_name": "D-valine metabolic process", "definition": "The chemical reactions and pathways involving D-valine. [GOC:TermGenie, PMID:23085840]"}
{"concept_id": "C3821573", "aliases": [], "types": ["T043"], "canonical_name": "regulation of organelle assembly", "definition": "Any process that modulates the frequency, rate or extent of organelle assembly. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3821574", "aliases": ["down-regulation of organelle assembly", "down regulation of organelle assembly", "downregulation of organelle assembly"], "types": ["T043"], "canonical_name": "negative regulation of organelle assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3821575", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of organelle assembly"}
{"concept_id": "C3821576", "aliases": ["up regulation of organelle assembly", "upregulation of organelle assembly", "up-regulation of organelle assembly"], "types": ["T043"], "canonical_name": "positive regulation of organelle assembly", "definition": "Any process that activates or increases the frequency, rate or extent of organelle assembly. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3821577", "aliases": [], "types": ["T043"], "canonical_name": "activation of organelle assembly"}
{"concept_id": "C3821578", "aliases": ["25(OH)D3 binding", "calcifediol binding", "25-hydroxycholecalciferol binding", "25-hydroxyvitamin D3 binding", "25OHD3 binding"], "types": ["T044"], "canonical_name": "calcidiol binding", "definition": "Binding to calcidiol. [GOC:bf, GOC:TermGenie, PMID:11799400]"}
{"concept_id": "C3821579", "aliases": ["regulation of spindle elongation during meiosis"], "types": ["T043"], "canonical_name": "regulation of meiotic spindle elongation", "definition": "Any process that modulates the frequency, rate or extent of meiotic spindle elongation. [GOC:TermGenie, PMID:23370392]"}
{"concept_id": "C3821580", "aliases": ["inhibition of spindle elongation during meiosis", "down-regulation of meiotic spindle elongation", "downregulation of meiotic spindle elongation", "negative regulation of spindle elongation during meiosis", "down regulation of meiotic spindle elongation", "downregulation of spindle elongation during meiosis", "down-regulation of spindle elongation during meiosis", "down regulation of spindle elongation during meiosis"], "types": ["T043"], "canonical_name": "negative regulation of meiotic spindle elongation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic spindle elongation. [GOC:TermGenie, PMID:23370392]"}
{"concept_id": "C3821581", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of meiotic spindle elongation"}
{"concept_id": "C3821582", "aliases": ["LCA binding"], "types": ["T044"], "canonical_name": "lithocholic acid binding", "definition": "Binding to lithocholic acid. [GOC:bf, GOC:TermGenie, PMID:20371703]"}
{"concept_id": "C3821583", "aliases": ["CDCA binding"], "types": ["T044"], "canonical_name": "chenodeoxycholic acid binding", "definition": "Binding to chenodeoxycholic acid. [GOC:bf, GOC:TermGenie, PMID:10334992]"}
{"concept_id": "C3821584", "aliases": ["(-)-pinoresinol breakdown", "(-)-pinoresinol degradation", "(-)-pinoresinol catabolism"], "types": ["T044"], "canonical_name": "(-)-pinoresinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (-)-pinoresinol. [GOC:TermGenie, PMID:15949826, PMID:9872995]"}
{"concept_id": "C3821585", "aliases": ["(+)-pinoresinol metabolism"], "types": ["T044"], "canonical_name": "(+)-pinoresinol metabolic process", "definition": "The chemical reactions and pathways involving (+)-pinoresinol. [GOC:TermGenie, PMID:8910615, PMID:9872995]"}
{"concept_id": "C3821586", "aliases": ["(+)-pinoresinol breakdown", "(+)-pinoresinol catabolism", "(+)-pinoresinol degradation"], "types": ["T044"], "canonical_name": "(+)-pinoresinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (+)-pinoresinol. [GOC:TermGenie, PMID:8910615, PMID:9872995]"}
{"concept_id": "C3821587", "aliases": ["(+)-pinoresinol anabolism", "(+)-pinoresinol synthesis", "(+)-pinoresinol formation", "(+)-pinoresinol biosynthesis"], "types": ["T044"], "canonical_name": "(+)-pinoresinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (+)-pinoresinol. [GOC:TermGenie, PMID:8910615, PMID:9872995]"}
{"concept_id": "C3821588", "aliases": ["(-)-lariciresinol metabolism"], "types": ["T044"], "canonical_name": "(-)-lariciresinol metabolic process", "definition": "The chemical reactions and pathways involving (-)-lariciresinol. [GOC:TermGenie, PMID:15949826, PMID:9872995]"}
{"concept_id": "C3821589", "aliases": ["(-)-lariciresinol degradation", "(-)-lariciresinol catabolism", "(-)-lariciresinol breakdown"], "types": ["T044"], "canonical_name": "(-)-lariciresinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (-)-lariciresinol. [GOC:TermGenie, PMID:15949826, PMID:9872995]"}
{"concept_id": "C3821590", "aliases": ["(-)-lariciresinol synthesis", "(-)-lariciresinol anabolism", "(-)-lariciresinol biosynthesis", "(-)-lariciresinol formation"], "types": ["T044"], "canonical_name": "(-)-lariciresinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (-)-lariciresinol. [GOC:TermGenie, PMID:15949826, PMID:9872995]"}
{"concept_id": "C3821591", "aliases": ["(+)-lariciresinol metabolism"], "types": ["T044"], "canonical_name": "(+)-lariciresinol metabolic process", "definition": "The chemical reactions and pathways involving (+)-lariciresinol. [GOC:TermGenie, PMID:8910615, PMID:9872995]"}
{"concept_id": "C3821592", "aliases": ["(+)-lariciresinol degradation", "(+)-lariciresinol breakdown", "(+)-lariciresinol catabolism"], "types": ["T044"], "canonical_name": "(+)-lariciresinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (+)-lariciresinol. [GOC:TermGenie, PMID:8910615, PMID:9872995]"}
{"concept_id": "C3821593", "aliases": ["(+)-lariciresinol synthesis", "(+)-lariciresinol anabolism", "(+)-lariciresinol biosynthesis", "(+)-lariciresinol formation"], "types": ["T044"], "canonical_name": "(+)-lariciresinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (+)-lariciresinol. [GOC:TermGenie, PMID:8910615, PMID:9872995]"}
{"concept_id": "C3821594", "aliases": ["(+)-secoisolariciresinol metabolism"], "types": ["T044"], "canonical_name": "(+)-secoisolariciresinol metabolic process", "definition": "The chemical reactions and pathways involving (+)-secoisolariciresinol. [GOC:TermGenie, PMID:15949826, PMID:9872995]"}
{"concept_id": "C3821595", "aliases": ["(+)-secoisolariciresinol catabolism", "(+)-secoisolariciresinol breakdown", "(+)-secoisolariciresinol degradation"], "types": ["T044"], "canonical_name": "(+)-secoisolariciresinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (+)-secoisolariciresinol. [GOC:TermGenie, PMID:15949826, PMID:9872995]"}
{"concept_id": "C3821596", "aliases": ["(+)-secoisolariciresinol biosynthesis", "(+)-secoisolariciresinol synthesis", "(+)-secoisolariciresinol formation", "(+)-secoisolariciresinol anabolism"], "types": ["T044"], "canonical_name": "(+)-secoisolariciresinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (+)-secoisolariciresinol. [GOC:TermGenie, PMID:15949826, PMID:9872995]"}
{"concept_id": "C3821597", "aliases": ["(-)-secoisolariciresinol metabolism"], "types": ["T044"], "canonical_name": "(-)-secoisolariciresinol metabolic process", "definition": "The chemical reactions and pathways involving (-)-secoisolariciresinol. [GOC:TermGenie, PMID:8910615, PMID:9872995]"}
{"concept_id": "C3821598", "aliases": ["(-)-secoisolariciresinol breakdown", "(-)-secoisolariciresinol degradation", "(-)-secoisolariciresinol catabolism"], "types": ["T044"], "canonical_name": "(-)-secoisolariciresinol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of (-)-secoisolariciresinol. [GOC:TermGenie, PMID:8910615, PMID:9872995]"}
{"concept_id": "C3821599", "aliases": ["(-)-secoisolariciresinol synthesis", "(-)-secoisolariciresinol anabolism", "(-)-secoisolariciresinol biosynthesis", "(-)-secoisolariciresinol formation"], "types": ["T044"], "canonical_name": "(-)-secoisolariciresinol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (-)-secoisolariciresinol. [GOC:TermGenie, PMID:8910615, PMID:9872995]"}
{"concept_id": "C3821600", "aliases": [], "types": ["T043"], "canonical_name": "response to inositol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus. [GOC:TermGenie, PMID:16496115]"}
{"concept_id": "C3821601", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to inositol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus. [GOC:TermGenie, PMID:16496115]"}
{"concept_id": "C3821602", "aliases": ["regulation of response to signal involved in cell cycle checkpoint", "regulation of cell cycle checkpoint effector process"], "types": ["T039"], "canonical_name": "regulation of response to cell cycle checkpoint signaling", "definition": "Any process that modulates the frequency, rate or extent of response to cell cycle checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821603", "aliases": [], "types": ["T039"], "canonical_name": "regulation of G1/S transition checkpoint effector process"}
{"concept_id": "C3821604", "aliases": ["regulation of response to signal involved in G2/M transition checkpoint"], "types": ["T043"], "canonical_name": "regulation of G2/M transition checkpoint effector process"}
{"concept_id": "C3821605", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to G1/S transition checkpoint signaling"}
{"concept_id": "C3821606", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to G2/M transition checkpoint signaling"}
{"concept_id": "C3821607", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to signal involved in G1/S transition checkpoint"}
{"concept_id": "C3821608", "aliases": ["positive regulation of cell cycle checkpoint effector process", "activation of cell cycle checkpoint effector process", "up-regulation of response to signal involved in cell cycle checkpoint", "upregulation of response to cell cycle checkpoint signaling", "upregulation of response to signal involved in cell cycle checkpoint", "up regulation of response to cell cycle checkpoint signaling", "up regulation of cell cycle checkpoint effector process", "up-regulation of response to cell cycle checkpoint signaling", "up-regulation of cell cycle checkpoint effector process", "up regulation of response to signal involved in cell cycle checkpoint", "positive regulation of response to signal involved in cell cycle checkpoint", "upregulation of cell cycle checkpoint effector process", "activation of response to signal involved in cell cycle checkpoint"], "types": ["T039"], "canonical_name": "positive regulation of response to cell cycle checkpoint signaling", "definition": "Any process that activates or increases the frequency, rate or extent of response to cell cycle checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821609", "aliases": [], "types": ["T039"], "canonical_name": "activation of G1/S transition checkpoint effector process"}
{"concept_id": "C3821610", "aliases": ["positive regulation of response to signal involved in G2/M transition checkpoint"], "types": ["T039"], "canonical_name": "activation of G2/M transition checkpoint effector process"}
{"concept_id": "C3821611", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to cell cycle checkpoint signaling"}
{"concept_id": "C3821612", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to G1/S transition checkpoint signaling"}
{"concept_id": "C3821613", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to G2/M transition checkpoint signaling"}
{"concept_id": "C3821614", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to signal involved in G1/S transition checkpoint"}
{"concept_id": "C3821615", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to signal involved in G2/M transition checkpoint"}
{"concept_id": "C3821616", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of G1/S transition checkpoint effector process"}
{"concept_id": "C3821617", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of G2/M transition checkpoint effector process"}
{"concept_id": "C3821618", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of response to G1/S transition checkpoint signaling"}
{"concept_id": "C3821619", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of response to G2/M transition checkpoint signaling"}
{"concept_id": "C3821620", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of response to signal involved in G1/S transition checkpoint"}
{"concept_id": "C3821621", "aliases": ["up-regulation of response to signal involved in G1/S transition checkpoint", "up regulation of response to signal involved in G1/S transition checkpoint", "up-regulation of G1/S transition checkpoint effector process"], "types": ["T043"], "canonical_name": "up regulation of G1/S transition checkpoint effector process"}
{"concept_id": "C3821622", "aliases": ["up-regulation of G2/M transition checkpoint effector process"], "types": ["T039"], "canonical_name": "up regulation of G2/M transition checkpoint effector process"}
{"concept_id": "C3821623", "aliases": ["up-regulation of response to G1/S transition checkpoint signaling"], "types": ["T039"], "canonical_name": "up regulation of response to G1/S transition checkpoint signaling"}
{"concept_id": "C3821624", "aliases": ["up-regulation of response to G2/M transition checkpoint signaling"], "types": ["T039"], "canonical_name": "up regulation of response to G2/M transition checkpoint signaling"}
{"concept_id": "C3821625", "aliases": ["up-regulation of response to signal involved in G2/M transition checkpoint"], "types": ["T039"], "canonical_name": "up regulation of response to signal involved in G2/M transition checkpoint"}
{"concept_id": "C3821626", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of G1/S transition checkpoint effector process"}
{"concept_id": "C3821627", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of G2/M transition checkpoint effector process"}
{"concept_id": "C3821628", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of response to G1/S transition checkpoint signaling"}
{"concept_id": "C3821629", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of response to G2/M transition checkpoint signaling"}
{"concept_id": "C3821630", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of response to signal involved in G1/S transition checkpoint"}
{"concept_id": "C3821631", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of response to signal involved in G2/M transition checkpoint"}
{"concept_id": "C3821632", "aliases": ["regulation of response to signal involved in cytokinesis checkpoint", "regulation of cytokinesis checkpoint effector process"], "types": ["T039"], "canonical_name": "regulation of response to cytokinesis checkpoint signaling", "definition": "Any process that modulates the frequency, rate or extent of response to cytokinesis checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821633", "aliases": ["upregulation of cytokinesis checkpoint effector process", "up-regulation of cytokinesis checkpoint effector process", "upregulation of response to signal involved in cytokinesis checkpoint", "activation of response to signal involved in cytokinesis checkpoint", "upregulation of response to cytokinesis checkpoint signaling", "up regulation of cytokinesis checkpoint effector process", "up-regulation of response to signal involved in cytokinesis checkpoint", "up regulation of response to cytokinesis checkpoint signaling", "activation of cytokinesis checkpoint effector process", "activation of response to cytokinesis checkpoint signaling", "up-regulation of response to cytokinesis checkpoint signaling", "positive regulation of cytokinesis checkpoint effector process", "up regulation of response to signal involved in cytokinesis checkpoint", "positive regulation of response to signal involved in cytokinesis checkpoint"], "types": ["T043"], "canonical_name": "positive regulation of response to cytokinesis checkpoint signaling", "definition": "Any process that activates or increases the frequency, rate or extent of response to cytokinesis checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821635", "aliases": ["regulation of DNA integrity checkpoint effector process", "regulation of response to signal involved in DNA integrity checkpoint"], "types": ["T039"], "canonical_name": "regulation of response to DNA integrity checkpoint signaling", "definition": "Any process that modulates the frequency, rate or extent of response to DNA integrity checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821636", "aliases": ["up-regulation of response to signal involved in DNA integrity checkpoint", "up regulation of DNA integrity checkpoint effector process", "up regulation of response to DNA integrity checkpoint signaling", "up regulation of response to signal involved in DNA integrity checkpoint", "upregulation of response to DNA integrity checkpoint signaling", "up-regulation of response to DNA integrity checkpoint signaling", "positive regulation of DNA integrity checkpoint effector process", "positive regulation of response to signal involved in DNA integrity checkpoint", "upregulation of response to signal involved in DNA integrity checkpoint", "activation of response to signal involved in DNA integrity checkpoint", "upregulation of DNA integrity checkpoint effector process", "activation of DNA integrity checkpoint effector process", "up-regulation of DNA integrity checkpoint effector process"], "types": ["T039"], "canonical_name": "positive regulation of response to DNA integrity checkpoint signaling", "definition": "Any process that activates or increases the frequency, rate or extent of response to DNA integrity checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821637", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to DNA integrity checkpoint signaling"}
{"concept_id": "C3821638", "aliases": ["regulation of response to signal involved in DNA damage checkpoint", "regulation of DNA damage checkpoint effector process"], "types": ["T039"], "canonical_name": "regulation of response to DNA damage checkpoint signaling", "definition": "Any process that modulates the frequency, rate or extent of response to DNA damage checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821639", "aliases": ["positive regulation of response to signal involved in DNA damage checkpoint", "upregulation of response to signal involved in DNA damage checkpoint", "up-regulation of response to DNA damage checkpoint signaling", "positive regulation of DNA damage checkpoint effector process", "up-regulation of DNA damage checkpoint effector process", "activation of DNA damage checkpoint effector process", "up regulation of response to signal involved in DNA damage checkpoint", "upregulation of DNA damage checkpoint effector process", "activation of response to signal involved in DNA damage checkpoint", "up regulation of DNA damage checkpoint effector process", "up-regulation of response to signal involved in DNA damage checkpoint", "up regulation of response to DNA damage checkpoint signaling", "upregulation of response to DNA damage checkpoint signaling"], "types": ["T039"], "canonical_name": "positive regulation of response to DNA damage checkpoint signaling", "definition": "Any process that activates or increases the frequency, rate or extent of response to DNA damage checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821640", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to DNA damage checkpoint signaling"}
{"concept_id": "C3821641", "aliases": ["regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint", "regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling", "regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process"], "types": ["T039"], "canonical_name": "regulation of response to G1 DNA damage checkpoint signaling", "definition": "Any process that modulates the frequency, rate or extent of response to G1 DNA damage checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821642", "aliases": ["up-regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process", "upregulation of response to G1 DNA damage checkpoint signaling", "upregulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process", "activation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process", "up-regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint", "upregulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling", "up regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint", "up-regulation of response to G1 DNA damage checkpoint signaling", "activation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint", "up regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling", "up regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process", "activation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling", "up-regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling", "activation of response to G1 DNA damage checkpoint signaling", "up regulation of response to G1 DNA damage checkpoint signaling", "upregulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint", "positive regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling", "positive regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint", "positive regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process"], "types": ["T043"], "canonical_name": "positive regulation of response to G1 DNA damage checkpoint signaling", "definition": "Any process that activates or increases the frequency, rate or extent of response to G1 DNA damage checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821643", "aliases": ["regulation of response to signal involved in G2/M transition DNA damage checkpoint", "regulation of G2/M transition DNA damage checkpoint effector process"], "types": ["T039"], "canonical_name": "regulation of response to G2 DNA damage checkpoint signaling", "definition": "Any process that modulates the frequency, rate or extent of response to G2 DNA damage checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821644", "aliases": ["upregulation of response to G2 DNA damage checkpoint signaling", "up regulation of response to signal involved in G2/M transition DNA damage checkpoint", "up regulation of G2/M transition DNA damage checkpoint effector process", "up-regulation of response to G2 DNA damage checkpoint signaling", "activation of G2/M transition DNA damage checkpoint effector process", "upregulation of response to signal involved in G2/M transition DNA damage checkpoint", "upregulation of G2/M transition DNA damage checkpoint effector process", "up-regulation of response to signal involved in G2/M transition DNA damage checkpoint", "up-regulation of G2/M transition DNA damage checkpoint effector process", "activation of response to signal involved in G2/M transition DNA damage checkpoint", "up regulation of response to G2 DNA damage checkpoint signaling", "positive regulation of response to signal involved in G2/M transition DNA damage checkpoint", "positive regulation of G2/M transition DNA damage checkpoint effector process"], "types": ["T039"], "canonical_name": "positive regulation of response to G2 DNA damage checkpoint signaling", "definition": "Any process that activates or increases the frequency, rate or extent of response to G2 DNA damage checkpoint signaling. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821645", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to G2 DNA damage checkpoint signaling"}
{"concept_id": "C3821646", "aliases": ["regulation of cyclic nucleotide-activated ion channel activity", "regulation of cyclic nucleotide gated ion channel activity", "regulation of cyclic nucleotide activated ion channel activity"], "types": ["T038"], "canonical_name": "regulation of cyclic nucleotide-gated ion channel activity", "definition": "Any process that modulates the frequency, rate or extent of cyclic nucleotide-gated ion channel activity. [GOC:TermGenie, PMID:11420311]"}
{"concept_id": "C3821647", "aliases": ["inhibition of cyclic nucleotide gated ion channel activity", "down regulation of cyclic nucleotide activated ion channel activity", "down-regulation of cyclic nucleotide-gated ion channel activity", "negative regulation of cyclic nucleotide activated ion channel activity", "downregulation of cyclic nucleotide-gated ion channel activity", "downregulation of cyclic nucleotide-activated ion channel activity", "negative regulation of cyclic nucleotide gated ion channel activity", "inhibition of cyclic nucleotide-activated ion channel activity", "negative regulation of cyclic nucleotide-activated ion channel activity", "down regulation of cyclic nucleotide gated ion channel activity", "down-regulation of cyclic nucleotide activated ion channel activity", "downregulation of cyclic nucleotide activated ion channel activity", "down regulation of cyclic nucleotide-activated ion channel activity", "inhibition of cyclic nucleotide-gated ion channel activity", "down-regulation of cyclic nucleotide-activated ion channel activity", "inhibition of cyclic nucleotide activated ion channel activity", "down-regulation of cyclic nucleotide gated ion channel activity", "down regulation of cyclic nucleotide-gated ion channel activity", "downregulation of cyclic nucleotide gated ion channel activity"], "types": ["T044"], "canonical_name": "negative regulation of cyclic nucleotide-gated ion channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cyclic nucleotide-gated ion channel activity. [GOC:TermGenie, PMID:11420311]"}
{"concept_id": "C3821649", "aliases": ["up-regulation of cyclic nucleotide gated ion channel activity", "activation of cyclic nucleotide-activated ion channel activity", "upregulation of cyclic nucleotide-activated ion channel activity", "positive regulation of cyclic nucleotide-activated ion channel activity", "upregulation of cyclic nucleotide-gated ion channel activity", "positive regulation of cyclic nucleotide gated ion channel activity", "up-regulation of cyclic nucleotide-gated ion channel activity", "up regulation of cyclic nucleotide activated ion channel activity", "up regulation of cyclic nucleotide-gated ion channel activity", "upregulation of cyclic nucleotide gated ion channel activity", "positive regulation of cyclic nucleotide activated ion channel activity", "up regulation of cyclic nucleotide gated ion channel activity", "upregulation of cyclic nucleotide activated ion channel activity", "up regulation of cyclic nucleotide-activated ion channel activity", "up-regulation of cyclic nucleotide activated ion channel activity", "up-regulation of cyclic nucleotide-activated ion channel activity", "activation of cyclic nucleotide activated ion channel activity", "activation of cyclic nucleotide gated ion channel activity", "activation of cyclic nucleotide-gated ion channel activity"], "types": ["T038"], "canonical_name": "positive regulation of cyclic nucleotide-gated ion channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity. [GOC:TermGenie, PMID:11420311]"}
{"concept_id": "C3821651", "aliases": [], "types": ["T044"], "canonical_name": "regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "definition": "Any process that modulates the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. [GOC:TermGenie, PMID:17719541]"}
{"concept_id": "C3821652", "aliases": ["downregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator"], "types": ["T044"], "canonical_name": "negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. [GOC:TermGenie, PMID:17719541]"}
{"concept_id": "C3821653", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator"}
{"concept_id": "C3821654", "aliases": ["upregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator"], "types": ["T045"], "canonical_name": "positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "definition": "Any process that activates or increases the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. [GOC:TermGenie, PMID:17719541]"}
{"concept_id": "C3821655", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator"}
{"concept_id": "C3821656", "aliases": ["regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"], "types": ["T043"], "canonical_name": "regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "definition": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. [GOC:TermGenie, PMID:17719541]"}
{"concept_id": "C3821657", "aliases": ["downregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"], "types": ["T043"], "canonical_name": "negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. [GOC:TermGenie, PMID:17719541]"}
{"concept_id": "C3821658", "aliases": ["down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"], "types": ["T043"], "canonical_name": "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821659", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821660", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821661", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"}
{"concept_id": "C3821662", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821663", "aliases": ["up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "up regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "upregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis", "activation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "definition": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. [GOC:TermGenie, PMID:17719541]"}
{"concept_id": "C3821664", "aliases": [], "types": ["T043"], "canonical_name": "activation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"}
{"concept_id": "C3821665", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821666", "aliases": ["up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"], "types": ["T043"], "canonical_name": "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821667", "aliases": [], "types": ["T043"], "canonical_name": "response to catechin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus. [GOC:rjd, GOC:TermGenie, PMID:23516620]"}
{"concept_id": "C3821668", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to catechin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus. [GOC:rjd, GOC:TermGenie, PMID:23516620]"}
{"concept_id": "C3821669", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to reactive nitrogen species", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus. [GOC:sl, GOC:TermGenie, PMID:22504638]"}
{"concept_id": "C3821670", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tocopherol cyclase activity", "definition": "Any process that modulates the frequency, rate or extent of tocopherol cyclase activity. [GOC:TermGenie, PMID:23632854]"}
{"concept_id": "C3821671", "aliases": [], "types": ["T043"], "canonical_name": "regulation of keratinocyte apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133]"}
{"concept_id": "C3821672", "aliases": [], "types": ["T043"], "canonical_name": "regulation of keratinocyte apoptosis"}
{"concept_id": "C3821673", "aliases": ["down-regulation of keratinocyte apoptotic process", "down regulation of keratinocyte apoptotic process", "downregulation of keratinocyte apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of keratinocyte apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133]"}
{"concept_id": "C3821674", "aliases": ["down-regulation of keratinocyte apoptosis"], "types": ["T043"], "canonical_name": "down regulation of keratinocyte apoptosis"}
{"concept_id": "C3821675", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of keratinocyte apoptosis"}
{"concept_id": "C3821676", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of keratinocyte apoptosis"}
{"concept_id": "C3821677", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of keratinocyte apoptotic process"}
{"concept_id": "C3821678", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of keratinocyte apoptosis"}
{"concept_id": "C3821679", "aliases": ["upregulation of keratinocyte apoptotic process", "up regulation of keratinocyte apoptotic process", "up-regulation of keratinocyte apoptotic process", "activation of keratinocyte apoptotic process", "upregulation of keratinocyte apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of keratinocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133]"}
{"concept_id": "C3821680", "aliases": [], "types": ["T043"], "canonical_name": "activation of keratinocyte apoptosis"}
{"concept_id": "C3821681", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of keratinocyte apoptosis"}
{"concept_id": "C3821682", "aliases": ["up-regulation of keratinocyte apoptosis"], "types": ["T043"], "canonical_name": "up regulation of keratinocyte apoptosis"}
{"concept_id": "C3821683", "aliases": ["regulation of intrinsic apoptotic signaling pathway in response to oxidative stress"], "types": ["T043"], "canonical_name": "regulation of oxidative stress-induced intrinsic apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]"}
{"concept_id": "C3821684", "aliases": ["downregulation of intrinsic apoptotic signaling pathway in response to oxidative stress", "down-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress", "negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress", "down regulation of intrinsic apoptotic signaling pathway in response to oxidative stress"], "types": ["T043"], "canonical_name": "negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]"}
{"concept_id": "C3821685", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intrinsic apoptotic signaling pathway in response to oxidative stress"}
{"concept_id": "C3821686", "aliases": ["up-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress", "upregulation of intrinsic apoptotic signaling pathway in response to oxidative stress", "positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress", "up regulation of intrinsic apoptotic signaling pathway in response to oxidative stress"], "types": ["T043"], "canonical_name": "positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]"}
{"concept_id": "C3821687", "aliases": [], "types": ["T043"], "canonical_name": "activation of intrinsic apoptotic signaling pathway in response to oxidative stress"}
{"concept_id": "C3821688", "aliases": ["fibroblast growth factor receptor signaling pathway involved in programmed cell death by apoptosis", "FGFR signaling pathway involved in signaling (initiator) caspase activity", "fibroblast growth factor receptor signaling pathway involved in apoptotic cell death", "FGFR signaling pathway involved in apoptotic cell death", "FGFR signaling pathway involved in apoptotic process", "fibroblast growth factor receptor signaling pathway involved in apoptotic programmed cell death", "FGF receptor signalling pathway involved in apoptotic program", "FGF receptor signalling pathway involved in programmed cell death by apoptosis", "FGF receptor signaling pathway involved in apoptotic cell death", "fibroblast growth factor receptor signalling pathway involved in programmed cell death by apoptosis", "fibroblast growth factor receptor signalling pathway involved in apoptotic programmed cell death", "FGF receptor signalling pathway involved in apoptotic process", "FGFR signaling pathway involved in programmed cell death by apoptosis", "FGF receptor signalling pathway involved in apoptotic programmed cell death", "FGFR signaling pathway involved in apoptotic programmed cell death", "FGF receptor signaling pathway involved in programmed cell death by apoptosis", "FGF receptor signalling pathway involved in apoptotic cell death", "fibroblast growth factor receptor signaling pathway involved in apoptotic process", "FGF receptor signaling pathway involved in apoptotic program", "fibroblast growth factor receptor signalling pathway involved in apoptotic process", "FGF receptor signaling pathway involved in apoptotic programmed cell death", "FGF receptor signaling pathway involved in apoptotic process", "fibroblast growth factor receptor signalling pathway involved in apoptotic cell death"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor apoptotic signaling pathway", "definition": "An apoptotic signaling pathway that starts with a ligand binding to, or being withdrawn from, a fibroblast growth factor receptor (FGFR). [GOC:mtg_apoptosis, GOC:pm, GOC:pr, GOC:TermGenie, PMID:17561467]"}
{"concept_id": "C3821689", "aliases": ["FGF receptor signalling pathway involved in apoptosis"], "types": ["T044"], "canonical_name": "FGF receptor signaling pathway involved in apoptosis"}
{"concept_id": "C3821690", "aliases": ["FGF receptor signalling pathway involved in signaling (initiator) caspase activity"], "types": ["T044"], "canonical_name": "FGF receptor signaling pathway involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821691", "aliases": ["FGF receptor signalling pathway involved in type I programmed cell death"], "types": ["T044"], "canonical_name": "FGF receptor signaling pathway involved in type I programmed cell death"}
{"concept_id": "C3821692", "aliases": [], "types": ["T044"], "canonical_name": "FGFR signaling pathway involved in apoptosis"}
{"concept_id": "C3821693", "aliases": [], "types": ["T044"], "canonical_name": "FGFR signaling pathway involved in apoptotic program"}
{"concept_id": "C3821694", "aliases": [], "types": ["T044"], "canonical_name": "FGFR signaling pathway involved in type I programmed cell death"}
{"concept_id": "C3821695", "aliases": ["fibroblast growth factor receptor signalling pathway involved in apoptosis"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in apoptosis"}
{"concept_id": "C3821696", "aliases": ["fibroblast growth factor receptor signalling pathway involved in apoptotic program"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in apoptotic program"}
{"concept_id": "C3821697", "aliases": ["fibroblast growth factor receptor signalling pathway involved in signaling (initiator) caspase activity"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in signaling (initiator) caspase activity"}
{"concept_id": "C3821698", "aliases": ["fibroblast growth factor receptor signalling pathway involved in type I programmed cell death"], "types": ["T044"], "canonical_name": "fibroblast growth factor receptor signaling pathway involved in type I programmed cell death"}
{"concept_id": "C3821699", "aliases": ["verruculogen metabolism"], "types": ["T044"], "canonical_name": "verruculogen metabolic process", "definition": "The chemical reactions and pathways involving verruculogen. [GOC:di, GOC:TermGenie, PMID:23649274]"}
{"concept_id": "C3821700", "aliases": ["verruculogen breakdown", "verruculogen degradation", "verruculogen catabolism"], "types": ["T044"], "canonical_name": "verruculogen catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of verruculogen. [GOC:di, GOC:TermGenie, PMID:23649274]"}
{"concept_id": "C3821701", "aliases": ["verruculogen formation", "verruculogen biosynthesis", "verruculogen anabolism", "verruculogen synthesis"], "types": ["T044"], "canonical_name": "verruculogen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of verruculogen. [GOC:di, GOC:TermGenie, PMID:23649274]"}
{"concept_id": "C3821702", "aliases": ["SAM development"], "types": ["T038"], "canonical_name": "shoot apical meristem development", "definition": "The process whose specific outcome is the progression of a shoot apical meristem over time, from its formation to the mature structure. [GOC:TermGenie, PMID:21496644]"}
{"concept_id": "C3821703", "aliases": [], "types": ["T038"], "canonical_name": "primary shoot meristem development"}
{"concept_id": "C3821704", "aliases": [], "types": ["T038"], "canonical_name": "promeristem development"}
{"concept_id": "C3821705", "aliases": ["regulation of SAM development"], "types": ["T038"], "canonical_name": "regulation of shoot apical meristem development", "definition": "Any process that modulates the frequency, rate or extent of shoot apical meristem development. [GOC:TermGenie, PMID:21496644]"}
{"concept_id": "C3821706", "aliases": [], "types": ["T038"], "canonical_name": "regulation of primary shoot meristem development"}
{"concept_id": "C3821707", "aliases": [], "types": ["T038"], "canonical_name": "regulation of promeristem development"}
{"concept_id": "C3821708", "aliases": ["down-regulation of SAM development", "negative regulation of SAM development", "down regulation of SAM development", "downregulation of shoot apical meristem development", "inhibition of SAM development", "downregulation of SAM development", "down-regulation of shoot apical meristem development", "down regulation of shoot apical meristem development"], "types": ["T039"], "canonical_name": "negative regulation of shoot apical meristem development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of shoot apical meristem development. [GOC:TermGenie, PMID:21496644]"}
{"concept_id": "C3821709", "aliases": ["down-regulation of primary shoot meristem development"], "types": ["T039"], "canonical_name": "down regulation of primary shoot meristem development"}
{"concept_id": "C3821710", "aliases": ["down-regulation of promeristem development"], "types": ["T039"], "canonical_name": "down regulation of promeristem development"}
{"concept_id": "C3821711", "aliases": [], "types": ["T039"], "canonical_name": "downregulation of primary shoot meristem development"}
{"concept_id": "C3821712", "aliases": [], "types": ["T039"], "canonical_name": "downregulation of promeristem development"}
{"concept_id": "C3821713", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of primary shoot meristem development"}
{"concept_id": "C3821714", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of promeristem development"}
{"concept_id": "C3821715", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of shoot apical meristem development"}
{"concept_id": "C3821716", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of primary shoot meristem development"}
{"concept_id": "C3821717", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of promeristem development"}
{"concept_id": "C3821718", "aliases": ["up-regulation of shoot apical meristem development", "positive regulation of SAM development", "up-regulation of SAM development", "upregulation of SAM development", "up regulation of shoot apical meristem development", "up regulation of SAM development", "upregulation of shoot apical meristem development", "activation of shoot apical meristem development", "activation of SAM development"], "types": ["T039"], "canonical_name": "positive regulation of shoot apical meristem development", "definition": "Any process that activates or increases the frequency, rate or extent of shoot apical meristem development. [GOC:TermGenie, PMID:21496644]"}
{"concept_id": "C3821719", "aliases": ["upregulation of primary shoot meristem development"], "types": ["T039"], "canonical_name": "activation of primary shoot meristem development"}
{"concept_id": "C3821720", "aliases": [], "types": ["T039"], "canonical_name": "activation of promeristem development"}
{"concept_id": "C3821721", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of primary shoot meristem development"}
{"concept_id": "C3821722", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of promeristem development"}
{"concept_id": "C3821723", "aliases": ["up-regulation of primary shoot meristem development"], "types": ["T039"], "canonical_name": "up regulation of primary shoot meristem development"}
{"concept_id": "C3821724", "aliases": ["up-regulation of promeristem development"], "types": ["T039"], "canonical_name": "up regulation of promeristem development"}
{"concept_id": "C3821725", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of promeristem development"}
{"concept_id": "C3821731", "aliases": ["2-methylbutanoyl-CoA(4-) metabolism"], "types": ["T044"], "canonical_name": "2-methylbutanoyl-CoA(4-) metabolic process", "definition": "The chemical reactions and pathways involving 2-methylbutanoyl-CoA(4-). [GOC:TermGenie, PMID:15574432]"}
{"concept_id": "C3821732", "aliases": ["2-methylbutanoyl-CoA(4-) catabolism", "2-methylbutanoyl-CoA(4-) breakdown", "2-methylbutanoyl-CoA(4-) degradation"], "types": ["T044"], "canonical_name": "2-methylbutanoyl-CoA(4-) catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-methylbutanoyl-CoA(4-). [GOC:TermGenie, PMID:15574432]"}
{"concept_id": "C3821733", "aliases": ["2-methylbutanoyl-CoA(4-) synthesis", "2-methylbutanoyl-CoA(4-) anabolism", "2-methylbutanoyl-CoA(4-) biosynthesis", "2-methylbutanoyl-CoA(4-) formation"], "types": ["T044"], "canonical_name": "2-methylbutanoyl-CoA(4-) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 2-methylbutanoyl-CoA(4-). [GOC:TermGenie, PMID:15574432]"}
{"concept_id": "C3821734", "aliases": ["2-methylbut-2-enoyl-CoA(4-) metabolism"], "types": ["T044"], "canonical_name": "2-methylbut-2-enoyl-CoA(4-) metabolic process", "definition": "The chemical reactions and pathways involving 2-methylbut-2-enoyl-CoA(4-). [GOC:TermGenie, PMID:15574432]"}
{"concept_id": "C3821735", "aliases": ["2-methylbut-2-enoyl-CoA(4-) degradation", "2-methylbut-2-enoyl-CoA(4-) catabolism", "2-methylbut-2-enoyl-CoA(4-) breakdown"], "types": ["T044"], "canonical_name": "2-methylbut-2-enoyl-CoA(4-) catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 2-methylbut-2-enoyl-CoA(4-). [GOC:TermGenie, PMID:15574432]"}
{"concept_id": "C3821736", "aliases": ["2-methylbut-2-enoyl-CoA(4-) synthesis", "2-methylbut-2-enoyl-CoA(4-) formation", "2-methylbut-2-enoyl-CoA(4-) biosynthesis", "2-methylbut-2-enoyl-CoA(4-) anabolism"], "types": ["T044"], "canonical_name": "2-methylbut-2-enoyl-CoA(4-) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 2-methylbut-2-enoyl-CoA(4-). [GOC:TermGenie, PMID:15574432]"}
{"concept_id": "C3821737", "aliases": ["isovaleryl-CoA(4-) metabolism"], "types": ["T044"], "canonical_name": "isovaleryl-CoA(4-) metabolic process", "definition": "The chemical reactions and pathways involving isovaleryl-CoA(4-). [GOC:TermGenie, pmid:11231285]"}
{"concept_id": "C3821738", "aliases": ["isovaleryl-CoA(4-) breakdown", "isovaleryl-CoA(4-) degradation", "isovaleryl-CoA(4-) catabolism"], "types": ["T044"], "canonical_name": "isovaleryl-CoA(4-) catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of isovaleryl-CoA(4-). [GOC:TermGenie, pmid:11231285]"}
{"concept_id": "C3821739", "aliases": ["isovaleryl-CoA(4-) biosynthesis", "isovaleryl-CoA(4-) anabolism", "isovaleryl-CoA(4-) formation", "isovaleryl-CoA(4-) synthesis"], "types": ["T044"], "canonical_name": "isovaleryl-CoA(4-) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of isovaleryl-CoA(4-). [GOC:TermGenie, pmid:11231285]"}
{"concept_id": "C3821740", "aliases": ["3-methylbut-2-enoyl-CoA(4-) metabolism"], "types": ["T044"], "canonical_name": "3-methylbut-2-enoyl-CoA(4-) metabolic process", "definition": "The chemical reactions and pathways involving 3-methylbut-2-enoyl-CoA(4-). [GOC:TermGenie, pmid:11231285]"}
{"concept_id": "C3821741", "aliases": ["3-methylbut-2-enoyl-CoA(4-) degradation", "3-methylbut-2-enoyl-CoA(4-) catabolism", "3-methylbut-2-enoyl-CoA(4-) breakdown"], "types": ["T044"], "canonical_name": "3-methylbut-2-enoyl-CoA(4-) catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3-methylbut-2-enoyl-CoA(4-). [GOC:TermGenie, pmid:11231285]"}
{"concept_id": "C3821742", "aliases": ["3-methylbut-2-enoyl-CoA(4-) synthesis", "3-methylbut-2-enoyl-CoA(4-) biosynthesis", "3-methylbut-2-enoyl-CoA(4-) anabolism", "3-methylbut-2-enoyl-CoA(4-) formation"], "types": ["T044"], "canonical_name": "3-methylbut-2-enoyl-CoA(4-) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 3-methylbut-2-enoyl-CoA(4-). [GOC:TermGenie, pmid:11231285]"}
{"concept_id": "C3821743", "aliases": ["down-regulation of flagellin-based flagellar cell motility", "inhibition of flagellin-based flagellar cell motility", "down-regulation of bacterial-type flagellar cell motility", "down regulation of bacterial-type flagellar cell motility", "negative regulation of flagellin-based flagellar cell motility", "downregulation of bacterial-type flagellar cell motility", "down regulation of flagellin-based flagellar cell motility", "downregulation of flagellin-based flagellar cell motility"], "types": ["T043"], "canonical_name": "negative regulation of bacterial-type flagellum-dependent cell motility", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility. [GOC:cilia, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3821744", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of bacterial-type flagellar cell motility"}
{"concept_id": "C3821745", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of bacterial-type flagellar cell motility"}
{"concept_id": "C3821746", "aliases": ["regulation of HGF receptor signaling pathway", "regulation of HGF receptor signalling pathway"], "types": ["T044"], "canonical_name": "regulation of hepatocyte growth factor receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway. [GOC:TermGenie, PMID:18819921]"}
{"concept_id": "C3821747", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Met signaling pathway"}
{"concept_id": "C3821748", "aliases": ["down-regulation of hepatocyte growth factor receptor signaling pathway", "negative regulation of HGF receptor signaling pathway", "down regulation of hepatocyte growth factor receptor signaling pathway", "down-regulation of HGF receptor signaling pathway", "down regulation of HGF receptor signalling pathway", "inhibition of hepatocyte growth factor receptor signaling pathway", "inhibition of HGF receptor signaling pathway", "negative regulation of HGF receptor signalling pathway", "downregulation of HGF receptor signaling pathway", "down-regulation of HGF receptor signalling pathway", "downregulation of HGF receptor signalling pathway", "inhibition of HGF receptor signalling pathway", "downregulation of hepatocyte growth factor receptor signaling pathway", "down regulation of HGF receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of hepatocyte growth factor receptor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway. [GOC:TermGenie, PMID:18819921]"}
{"concept_id": "C3821749", "aliases": ["down-regulation of Met signaling pathway"], "types": ["T044"], "canonical_name": "down regulation of Met signaling pathway"}
{"concept_id": "C3821750", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of Met signaling pathway"}
{"concept_id": "C3821751", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Met signaling pathway"}
{"concept_id": "C3821752", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of Met signaling pathway"}
{"concept_id": "C3821753", "aliases": ["activation of HGF receptor signaling pathway", "up regulation of HGF receptor signalling pathway", "up regulation of HGF receptor signaling pathway", "up-regulation of HGF receptor signaling pathway", "up-regulation of hepatocyte growth factor receptor signaling pathway", "up regulation of hepatocyte growth factor receptor signaling pathway", "upregulation of HGF receptor signaling pathway", "up-regulation of HGF receptor signalling pathway", "positive regulation of HGF receptor signalling pathway", "positive regulation of HGF receptor signaling pathway", "activation of HGF receptor signalling pathway", "upregulation of HGF receptor signalling pathway", "upregulation of hepatocyte growth factor receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of hepatocyte growth factor receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway. [GOC:TermGenie, PMID:18819921]"}
{"concept_id": "C3821754", "aliases": [], "types": ["T044"], "canonical_name": "activation of hepatocyte growth factor receptor signaling pathway"}
{"concept_id": "C3821755", "aliases": [], "types": ["T044"], "canonical_name": "activation of Met signaling pathway"}
{"concept_id": "C3821756", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Met signaling pathway"}
{"concept_id": "C3821757", "aliases": ["up-regulation of Met signaling pathway"], "types": ["T044"], "canonical_name": "up regulation of Met signaling pathway"}
{"concept_id": "C3821758", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of Met signaling pathway"}
{"concept_id": "C3821759", "aliases": ["regulation of interleukin-2-mediated signalling pathway", "regulation of IL-2-mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of interleukin-2-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of interleukin-2-mediated signaling pathway. [GOC:TermGenie, PMID:11909529]"}
{"concept_id": "C3821760", "aliases": ["down-regulation of interleukin-2-mediated signalling pathway", "down regulation of interleukin-2-mediated signalling pathway", "down regulation of interleukin-2-mediated signaling pathway", "down-regulation of interleukin-2-mediated signaling pathway", "downregulation of interleukin-2-mediated signalling pathway", "negative regulation of interleukin-2-mediated signalling pathway", "downregulation of interleukin-2-mediated signaling pathway", "inhibition of interleukin-2-mediated signalling pathway", "down regulation of IL-2-mediated signaling pathway", "downregulation of IL-2-mediated signaling pathway", "down-regulation of IL-2-mediated signaling pathway", "negative regulation of IL-2-mediated signaling pathway", "inhibition of interleukin-2-mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of interleukin-2-mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2-mediated signaling pathway. [GOC:TermGenie, PMID:11909529]"}
{"concept_id": "C3821761", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of IL-2-mediated signaling pathway"}
{"concept_id": "C3821762", "aliases": ["upregulation of interleukin-2-mediated signaling pathway", "up regulation of interleukin-2-mediated signalling pathway", "up-regulation of interleukin-2-mediated signaling pathway", "up regulation of IL-2-mediated signaling pathway", "up regulation of interleukin-2-mediated signaling pathway", "up-regulation of interleukin-2-mediated signalling pathway", "upregulation of interleukin-2-mediated signalling pathway", "activation of IL-2-mediated signaling pathway", "positive regulation of interleukin-2-mediated signalling pathway", "up-regulation of IL-2-mediated signaling pathway", "positive regulation of IL-2-mediated signaling pathway", "upregulation of IL-2-mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of interleukin-2-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-2-mediated signaling pathway. [GOC:TermGenie, PMID:11909529]"}
{"concept_id": "C3821763", "aliases": ["activation of interleukin-2-mediated signalling pathway"], "types": ["T044"], "canonical_name": "activation of interleukin-2-mediated signaling pathway"}
{"concept_id": "C3821764", "aliases": ["regulation of bacterial flagellum assembly"], "types": ["T043"], "canonical_name": "regulation of bacterial-type flagellum assembly", "definition": "Any process that modulates the frequency, rate or extent of bacterial-type flagellum assembly. [GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3821765", "aliases": ["down-regulation of bacterial flagellum assembly", "down regulation of bacterial flagellum assembly", "down regulation of bacterial-type flagellum assembly", "downregulation of bacterial-type flagellum assembly", "downregulation of bacterial flagellum assembly", "negative regulation of bacterial flagellum assembly", "down-regulation of bacterial-type flagellum assembly"], "types": ["T043"], "canonical_name": "negative regulation of bacterial-type flagellum assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum assembly. [GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3821766", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of bacterial flagellum assembly"}
{"concept_id": "C3821767", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of bacterial-type flagellum assembly"}
{"concept_id": "C3821768", "aliases": ["positive regulation of bacterial flagellum assembly", "up regulation of bacterial flagellum assembly", "up-regulation of bacterial flagellum assembly", "up regulation of bacterial-type flagellum assembly", "upregulation of bacterial flagellum assembly", "upregulation of bacterial-type flagellum assembly", "up-regulation of bacterial-type flagellum assembly"], "types": ["T043"], "canonical_name": "positive regulation of bacterial-type flagellum assembly", "definition": "Any process that activates or increases the frequency, rate or extent of bacterial-type flagellum assembly. [GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3821769", "aliases": [], "types": ["T043"], "canonical_name": "activation of bacterial flagellum assembly"}
{"concept_id": "C3821770", "aliases": [], "types": ["T043"], "canonical_name": "activation of bacterial-type flagellum assembly"}
{"concept_id": "C3821771", "aliases": ["regulation of prolactin-mediated signaling pathway", "regulation of PRL signaling pathway"], "types": ["T044"], "canonical_name": "regulation of prolactin signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of prolactin signaling pathway. [GOC:TermGenie, PMID:11773439]"}
{"concept_id": "C3821772", "aliases": ["downregulation of prolactin signaling pathway", "negative regulation of prolactin-mediated signaling pathway", "down regulation of prolactin-mediated signaling pathway", "inhibition of PRL signaling pathway", "negative regulation of PRL signaling pathway", "down-regulation of prolactin signaling pathway", "downregulation of PRL signaling pathway", "down-regulation of PRL signaling pathway", "down regulation of prolactin signaling pathway", "downregulation of prolactin-mediated signaling pathway", "down regulation of PRL signaling pathway", "down-regulation of prolactin-mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of prolactin signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin signaling pathway. [GOC:TermGenie, PMID:11773439]"}
{"concept_id": "C3821773", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of prolactin signaling pathway"}
{"concept_id": "C3821774", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of prolactin-mediated signaling pathway"}
{"concept_id": "C3821775", "aliases": ["upregulation of prolactin signaling pathway", "activation of prolactin signaling pathway", "up regulation of prolactin-mediated signaling pathway", "positive regulation of prolactin-mediated signaling pathway", "up-regulation of PRL signaling pathway", "upregulation of prolactin-mediated signaling pathway", "up regulation of PRL signaling pathway", "upregulation of PRL signaling pathway", "up-regulation of prolactin-mediated signaling pathway", "up-regulation of prolactin signaling pathway", "positive regulation of PRL signaling pathway", "up regulation of prolactin signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of prolactin signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway. [GOC:TermGenie, PMID:11773439]"}
{"concept_id": "C3821776", "aliases": [], "types": ["T044"], "canonical_name": "activation of PRL signaling pathway"}
{"concept_id": "C3821777", "aliases": [], "types": ["T044"], "canonical_name": "activation of prolactin-mediated signaling pathway"}
{"concept_id": "C3821778", "aliases": ["regulation of interleukin-4-mediated signalling pathway", "regulation of IL-4-mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of interleukin-4-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of interleukin-4-mediated signaling pathway. [GOC:TermGenie, PMID:17210636]"}
{"concept_id": "C3821779", "aliases": ["negative regulation of interleukin-4-mediated signalling pathway", "downregulation of interleukin-4-mediated signaling pathway", "down-regulation of interleukin-4-mediated signaling pathway", "down regulation of interleukin-4-mediated signalling pathway", "down regulation of IL-4-mediated signaling pathway", "down-regulation of interleukin-4-mediated signalling pathway", "downregulation of interleukin-4-mediated signalling pathway", "down regulation of interleukin-4-mediated signaling pathway", "down-regulation of IL-4-mediated signaling pathway", "negative regulation of IL-4-mediated signaling pathway", "downregulation of IL-4-mediated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of interleukin-4-mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4-mediated signaling pathway. [GOC:TermGenie, PMID:17210636]"}
{"concept_id": "C3821780", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of IL-4-mediated signaling pathway"}
{"concept_id": "C3821781", "aliases": ["inhibition of interleukin-4-mediated signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of interleukin-4-mediated signaling pathway"}
{"concept_id": "C3821782", "aliases": ["up-regulation of interleukin-4-mediated signaling pathway", "up regulation of interleukin-4-mediated signalling pathway", "up-regulation of IL-4-mediated signaling pathway", "positive regulation of interleukin-4-mediated signalling pathway", "activation of interleukin-4-mediated signalling pathway", "up regulation of IL-4-mediated signaling pathway", "upregulation of IL-4-mediated signaling pathway", "positive regulation of IL-4-mediated signaling pathway", "upregulation of interleukin-4-mediated signaling pathway", "upregulation of interleukin-4-mediated signalling pathway", "up-regulation of interleukin-4-mediated signalling pathway", "activation of interleukin-4-mediated signaling pathway", "up regulation of interleukin-4-mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of interleukin-4-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway. [GOC:TermGenie, PMID:17210636]"}
{"concept_id": "C3821783", "aliases": [], "types": ["T044"], "canonical_name": "activation of IL-4-mediated signaling pathway"}
{"concept_id": "C3821784", "aliases": ["erythrocyte apoptosis", "RBC apoptosis", "RBC apoptotic process", "red blood cell apoptotic process"], "types": ["T043"], "definition": "Any apoptotic process in an erythrocyte. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]", "canonical_name": "erythrocyte apoptotic process"}
{"concept_id": "C3821785", "aliases": [], "types": ["T043"], "canonical_name": "red blood cell apoptosis"}
{"concept_id": "C3821786", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "definition": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]"}
{"concept_id": "C3821787", "aliases": ["downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress"], "types": ["T044"], "canonical_name": "negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]"}
{"concept_id": "C3821788", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress"}
{"concept_id": "C3821789", "aliases": ["upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress"], "types": ["T044"], "canonical_name": "positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "definition": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]"}
{"concept_id": "C3821790", "aliases": [], "types": ["T044"], "canonical_name": "activation of intrinsic apoptotic signaling pathway in response to osmotic stress"}
{"concept_id": "C3821791", "aliases": ["erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolism"], "types": ["T044"], "canonical_name": "erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process", "definition": "The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3821792", "aliases": ["erythrose 4-phosphate/phosphoenolpyruvate family amino acid breakdown", "erythrose 4-phosphate/phosphoenolpyruvate family amino acid degradation", "erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolism"], "types": ["T044"], "canonical_name": "erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3821793", "aliases": ["erythrose 4-phosphate/phosphoenolpyruvate family amino acid anabolism", "erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthesis", "erythrose 4-phosphate/phosphoenolpyruvate family amino acid formation", "erythrose 4-phosphate/phosphoenolpyruvate family amino acid synthesis"], "types": ["T044"], "canonical_name": "erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3821794", "aliases": ["ketone body metabolism"], "types": ["T038"], "canonical_name": "ketone body metabolic process", "definition": "The chemical reactions and pathways involving ketone body. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3821795", "aliases": ["down-regulation of acrosome reaction", "down regulation of acrosome reaction", "downregulation of acrosome reaction"], "types": ["T043"], "canonical_name": "negative regulation of acrosome reaction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of acrosome reaction. [GOC:TermGenie, PMID:23430248]"}
{"concept_id": "C3821796", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of acrosome reaction"}
{"concept_id": "C3821797", "aliases": ["regulation of macrophage colony-stimulating factor signalling pathway", "regulation of M-CSF signaling pathway"], "types": ["T044"], "canonical_name": "regulation of macrophage colony-stimulating factor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. [GOC:TermGenie, PMID:16705167]"}
{"concept_id": "C3821798", "aliases": ["downregulation of macrophage colony-stimulating factor signaling pathway", "down-regulation of M-CSF signaling pathway", "down regulation of macrophage colony-stimulating factor signalling pathway", "negative regulation of M-CSF signaling pathway", "down-regulation of macrophage colony-stimulating factor signaling pathway", "downregulation of M-CSF signaling pathway", "negative regulation of macrophage colony-stimulating factor signalling pathway", "down-regulation of macrophage colony-stimulating factor signalling pathway", "downregulation of macrophage colony-stimulating factor signalling pathway", "down regulation of macrophage colony-stimulating factor signaling pathway", "down regulation of M-CSF signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of macrophage colony-stimulating factor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. [GOC:TermGenie, PMID:16705167]"}
{"concept_id": "C3821799", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of M-CSF signaling pathway"}
{"concept_id": "C3821800", "aliases": ["inhibition of macrophage colony-stimulating factor signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of macrophage colony-stimulating factor signaling pathway"}
{"concept_id": "C3821801", "aliases": ["up regulation of macrophage colony-stimulating factor signaling pathway", "upregulation of macrophage colony-stimulating factor signalling pathway", "upregulation of macrophage colony-stimulating factor signaling pathway", "positive regulation of M-CSF signaling pathway", "up-regulation of macrophage colony-stimulating factor signalling pathway", "up regulation of macrophage colony-stimulating factor signalling pathway", "up-regulation of macrophage colony-stimulating factor signaling pathway", "upregulation of M-CSF signaling pathway", "positive regulation of macrophage colony-stimulating factor signalling pathway", "activation of M-CSF signaling pathway", "up regulation of M-CSF signaling pathway", "up-regulation of M-CSF signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of macrophage colony-stimulating factor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. [GOC:TermGenie, PMID:16705167]"}
{"concept_id": "C3821802", "aliases": ["activation of macrophage colony-stimulating factor signalling pathway"], "types": ["T044"], "canonical_name": "activation of macrophage colony-stimulating factor signaling pathway"}
{"concept_id": "C3821803", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "definition": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]"}
{"concept_id": "C3821804", "aliases": [], "types": ["T043"], "canonical_name": "regulation of DNA damage response, signal transduction resulting in induction of apoptosis"}
{"concept_id": "C3821805", "aliases": ["downregulation of DNA damage response, signal transduction resulting in induction of apoptosis", "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "downregulation of intrinsic apoptotic signaling pathway in response to DNA damage", "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage", "inhibition of DNA damage response, signal transduction resulting in induction of apoptosis", "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage"], "types": ["T044"], "canonical_name": "negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]"}
{"concept_id": "C3821806", "aliases": ["down-regulation of DNA damage response, signal transduction resulting in induction of apoptosis"], "types": ["T043"], "canonical_name": "down regulation of DNA damage response, signal transduction resulting in induction of apoptosis"}
{"concept_id": "C3821807", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of DNA damage response, signal transduction resulting in induction of apoptosis"}
{"concept_id": "C3821808", "aliases": ["up regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage"], "types": ["T043"], "canonical_name": "positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "definition": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]"}
{"concept_id": "C3821809", "aliases": [], "types": ["T043"], "canonical_name": "activation of DNA damage response, signal transduction resulting in induction of apoptosis"}
{"concept_id": "C3821810", "aliases": [], "types": ["T043"], "canonical_name": "activation of intrinsic apoptotic signaling pathway in response to DNA damage"}
{"concept_id": "C3821811", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of DNA damage response, signal transduction resulting in induction of apoptosis"}
{"concept_id": "C3821812", "aliases": ["up-regulation of DNA damage response, signal transduction resulting in induction of apoptosis"], "types": ["T043"], "canonical_name": "up regulation of DNA damage response, signal transduction resulting in induction of apoptosis"}
{"concept_id": "C3821813", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of DNA damage response, signal transduction resulting in induction of apoptosis"}
{"concept_id": "C3821814", "aliases": ["regulation of positive thymic T-lymphocyte selection", "regulation of positive thymic T-cell selection", "regulation of positive thymic T lymphocyte selection"], "types": ["T043"], "canonical_name": "regulation of positive thymic T cell selection", "definition": "Any process that modulates the frequency, rate or extent of positive thymic T cell selection. [GOC:TermGenie, PMID:22080863]"}
{"concept_id": "C3821815", "aliases": ["down regulation of positive thymic T cell selection", "downregulation of positive thymic T cell selection", "down regulation of positive thymic T lymphocyte selection", "downregulation of positive thymic T-cell selection", "downregulation of positive thymic T-lymphocyte selection", "down-regulation of positive thymic T-cell selection", "down regulation of positive thymic T-lymphocyte selection", "negative regulation of positive thymic T-lymphocyte selection", "negative regulation of positive thymic T-cell selection", "negative regulation of positive thymic T lymphocyte selection", "down-regulation of positive thymic T lymphocyte selection", "down regulation of positive thymic T-cell selection", "down-regulation of positive thymic T cell selection", "downregulation of positive thymic T lymphocyte selection", "down-regulation of positive thymic T-lymphocyte selection"], "types": ["T039"], "canonical_name": "negative regulation of positive thymic T cell selection", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection. [GOC:TermGenie, PMID:22080863]"}
{"concept_id": "C3821816", "aliases": ["inhibition of positive thymic T-cell selection"], "types": ["T039"], "canonical_name": "inhibition of positive thymic T cell selection"}
{"concept_id": "C3821817", "aliases": ["inhibition of positive thymic T-lymphocyte selection"], "types": ["T039"], "canonical_name": "inhibition of positive thymic T lymphocyte selection"}
{"concept_id": "C3821818", "aliases": ["up regulation of positive thymic T-lymphocyte selection", "up-regulation of positive thymic T cell selection", "up-regulation of positive thymic T lymphocyte selection", "upregulation of positive thymic T-lymphocyte selection", "positive regulation of positive thymic T-cell selection", "positive regulation of positive thymic T lymphocyte selection", "up-regulation of positive thymic T-lymphocyte selection", "up regulation of positive thymic T lymphocyte selection", "upregulation of positive thymic T lymphocyte selection", "up regulation of positive thymic T-cell selection", "upregulation of positive thymic T-cell selection", "up regulation of positive thymic T cell selection", "up-regulation of positive thymic T-cell selection", "positive regulation of positive thymic T-lymphocyte selection", "activation of positive thymic T-cell selection", "activation of positive thymic T cell selection", "upregulation of positive thymic T cell selection"], "types": ["T043"], "canonical_name": "positive regulation of positive thymic T cell selection", "definition": "Any process that activates or increases the frequency, rate or extent of positive thymic T cell selection. [GOC:TermGenie, PMID:22080863]"}
{"concept_id": "C3821819", "aliases": ["activation of positive thymic T-lymphocyte selection"], "types": ["T039"], "canonical_name": "activation of positive thymic T lymphocyte selection"}
{"concept_id": "C3821820", "aliases": ["regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "regulation of ER stress-induced apoptosis", "regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "regulation of apoptosis triggered by ER stress", "regulation of endoplasmic reticulum stress-induced apoptosis", "regulation of apoptosis in response to ER stress"], "types": ["T043"], "canonical_name": "regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]"}
{"concept_id": "C3821821", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptosis in response to endoplasmic reticulum stress"}
{"concept_id": "C3821822", "aliases": ["downregulation of apoptosis triggered by ER stress", "down-regulation of apoptosis in response to ER stress", "down-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "negative regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "down-regulation of apoptosis triggered by ER stress", "down regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "negative regulation of ER stress-induced apoptosis", "negative regulation of endoplasmic reticulum stress-induced apoptosis", "negative regulation of apoptosis triggered by ER stress", "down-regulation of ER stress-induced apoptosis", "down regulation of apoptosis in response to ER stress", "down-regulation of endoplasmic reticulum stress-induced apoptosis", "down regulation of endoplasmic reticulum stress-induced apoptosis", "down regulation of ER stress-induced apoptosis", "down-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "downregulation of apoptosis in response to ER stress", "downregulation of endoplasmic reticulum stress-induced apoptosis", "down regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "downregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "inhibition of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "downregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "negative regulation of apoptosis in response to ER stress", "down regulation of apoptosis triggered by ER stress", "downregulation of ER stress-induced apoptosis"], "types": ["T044"], "canonical_name": "negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]"}
{"concept_id": "C3821823", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of apoptosis in response to ER stress"}
{"concept_id": "C3821824", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of apoptosis triggered by ER stress"}
{"concept_id": "C3821825", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of endoplasmic reticulum stress-induced apoptosis"}
{"concept_id": "C3821826", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ER stress-induced apoptosis"}
{"concept_id": "C3821827", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress"}
{"concept_id": "C3821828", "aliases": ["up regulation of apoptosis in response to ER stress", "upregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "positive regulation of ER stress-induced apoptosis", "up-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "upregulation of endoplasmic reticulum stress-induced apoptosis", "upregulation of apoptosis in response to ER stress", "up-regulation of apoptosis triggered by ER stress", "positive regulation of apoptosis triggered by ER stress", "positive regulation of endoplasmic reticulum stress-induced apoptosis", "positive regulation of apoptosis in response to ER stress", "up regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "up-regulation of apoptosis in response to ER stress", "up regulation of endoplasmic reticulum stress-induced apoptosis", "up-regulation of ER stress-induced apoptosis", "upregulation of apoptosis triggered by ER stress", "up-regulation of endoplasmic reticulum stress-induced apoptosis", "positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "up regulation of ER stress-induced apoptosis", "up-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "up regulation of apoptosis triggered by ER stress", "positive regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "up regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress", "upregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "upregulation of ER stress-induced apoptosis"], "types": ["T044"], "canonical_name": "positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]"}
{"concept_id": "C3821829", "aliases": [], "types": ["T044"], "canonical_name": "activation of apoptosis in response to ER stress"}
{"concept_id": "C3821830", "aliases": [], "types": ["T044"], "canonical_name": "activation of apoptosis triggered by ER stress"}
{"concept_id": "C3821831", "aliases": [], "types": ["T044"], "canonical_name": "activation of endoplasmic reticulum stress-induced apoptosis"}
{"concept_id": "C3821832", "aliases": [], "types": ["T044"], "canonical_name": "activation of ER stress-induced apoptosis"}
{"concept_id": "C3821833", "aliases": [], "types": ["T044"], "canonical_name": "activation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"}
{"concept_id": "C3821834", "aliases": [], "types": ["T044"], "canonical_name": "activation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress"}
{"concept_id": "C3821835", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator", "definition": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]"}
{"concept_id": "C3821836", "aliases": ["down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator", "downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator", "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator"], "types": ["T044"], "canonical_name": "negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]"}
{"concept_id": "C3821837", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator"}
{"concept_id": "C3821838", "aliases": ["activation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator", "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator", "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator", "upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator"], "types": ["T044"], "canonical_name": "positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator", "definition": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]"}
{"concept_id": "C3821839", "aliases": ["copal-8-ol diphosphate(3-) metabolism"], "types": ["T044"], "canonical_name": "copal-8-ol diphosphate(3-) metabolic process", "definition": "The chemical reactions and pathways involving copal-8-ol diphosphate(3-). [GOC:TermGenie, pmid:22672125]"}
{"concept_id": "C3821840", "aliases": ["copal-8-ol diphosphate(3-) catabolism", "copal-8-ol diphosphate(3-) degradation", "copal-8-ol diphosphate(3-) breakdown"], "types": ["T044"], "canonical_name": "copal-8-ol diphosphate(3-) catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of copal-8-ol diphosphate(3-). [GOC:TermGenie, pmid:22672125]"}
{"concept_id": "C3821841", "aliases": ["copal-8-ol diphosphate(3-) synthesis", "copal-8-ol diphosphate(3-) biosynthesis", "copal-8-ol diphosphate(3-) anabolism", "copal-8-ol diphosphate(3-) formation"], "types": ["T044"], "canonical_name": "copal-8-ol diphosphate(3-) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of copal-8-ol diphosphate(3-). [GOC:TermGenie, pmid:22672125]"}
{"concept_id": "C3821842", "aliases": ["cis-abienol metabolism"], "types": ["T044"], "canonical_name": "cis-abienol metabolic process", "definition": "The chemical reactions and pathways involving cis-abienol. [GOC:TermGenie, pmid:22672125]"}
{"concept_id": "C3821843", "aliases": ["cis-abienol catabolism", "cis-abienol breakdown", "cis-abienol degradation"], "types": ["T044"], "canonical_name": "cis-abienol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cis-abienol. [GOC:TermGenie, pmid:22672125]"}
{"concept_id": "C3821844", "aliases": ["cis-abienol anabolism", "cis-abienol synthesis", "cis-abienol formation", "cis-abienol biosynthesis"], "types": ["T044"], "canonical_name": "cis-abienol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cis-abienol. [GOC:TermGenie, pmid:22672125]"}
{"concept_id": "C3821845", "aliases": ["geranylgeranyl diphosphate breakdown", "geranylgeranyl diphosphate degradation", "geranylgeranyl diphosphate catabolism"], "types": ["T044"], "canonical_name": "geranylgeranyl diphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of geranylgeranyl diphosphate. [GOC:TermGenie, pmid:22672125]"}
{"concept_id": "C3821846", "aliases": ["5-phosphoribose 1-diphosphate binding", "phosphoribosylpyrophosphate binding"], "types": ["T044"], "canonical_name": "5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding", "definition": "Binding to 5-O-phosphono-alpha-D-ribofuranosyl diphosphate. [GOC:mah, GOC:TermGenie, PMID:4314233]"}
{"concept_id": "C3821847", "aliases": [], "types": ["T044"], "canonical_name": "IMP binding", "definition": "Binding to IMP, inosine monophosphate. [GOC:mah, GOC:TermGenie, PMID:4314233]"}
{"concept_id": "C3821848", "aliases": ["regulation of RBC apoptotic process", "regulation of red blood cell apoptotic process"], "types": ["T043"], "canonical_name": "regulation of erythrocyte apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]"}
{"concept_id": "C3821849", "aliases": [], "types": ["T043"], "canonical_name": "regulation of erythrocyte apoptosis"}
{"concept_id": "C3821850", "aliases": [], "types": ["T043"], "canonical_name": "regulation of RBC apoptosis"}
{"concept_id": "C3821851", "aliases": [], "types": ["T043"], "canonical_name": "regulation of red blood cell apoptosis"}
{"concept_id": "C3821852", "aliases": ["down-regulation of RBC apoptotic process", "negative regulation of RBC apoptotic process", "downregulation of erythrocyte apoptotic process", "downregulation of RBC apoptotic process", "downregulation of red blood cell apoptotic process", "down regulation of red blood cell apoptotic process", "down regulation of erythrocyte apoptotic process", "inhibition of erythrocyte apoptotic process", "downregulation of red blood cell apoptosis", "down regulation of RBC apoptotic process", "down-regulation of red blood cell apoptotic process", "down-regulation of erythrocyte apoptotic process", "negative regulation of red blood cell apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of erythrocyte apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]"}
{"concept_id": "C3821853", "aliases": ["down-regulation of erythrocyte apoptosis"], "types": ["T043"], "canonical_name": "down regulation of erythrocyte apoptosis"}
{"concept_id": "C3821854", "aliases": ["down-regulation of RBC apoptosis"], "types": ["T043"], "canonical_name": "down regulation of RBC apoptosis"}
{"concept_id": "C3821855", "aliases": ["down-regulation of red blood cell apoptosis"], "types": ["T043"], "canonical_name": "down regulation of red blood cell apoptosis"}
{"concept_id": "C3821856", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of erythrocyte apoptosis"}
{"concept_id": "C3821857", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of RBC apoptosis"}
{"concept_id": "C3821858", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of erythrocyte apoptosis"}
{"concept_id": "C3821859", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of RBC apoptosis"}
{"concept_id": "C3821860", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of RBC apoptotic process"}
{"concept_id": "C3821861", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of red blood cell apoptosis"}
{"concept_id": "C3821862", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of red blood cell apoptotic process"}
{"concept_id": "C3821863", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of erythrocyte apoptosis"}
{"concept_id": "C3821864", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of RBC apoptosis"}
{"concept_id": "C3821865", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of red blood cell apoptosis"}
{"concept_id": "C3821866", "aliases": ["positive regulation of red blood cell apoptotic process", "up-regulation of red blood cell apoptotic process", "upregulation of RBC apoptosis", "upregulation of red blood cell apoptotic process", "upregulation of erythrocyte apoptotic process", "up-regulation of erythrocyte apoptotic process", "up regulation of erythrocyte apoptosis", "up regulation of red blood cell apoptotic process", "positive regulation of RBC apoptotic process", "up-regulation of erythrocyte apoptosis", "activation of red blood cell apoptotic process", "up regulation of erythrocyte apoptotic process", "up-regulation of RBC apoptotic process", "up regulation of RBC apoptotic process", "upregulation of RBC apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of erythrocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]"}
{"concept_id": "C3821867", "aliases": [], "types": ["T043"], "canonical_name": "activation of erythrocyte apoptosis"}
{"concept_id": "C3821868", "aliases": [], "types": ["T043"], "canonical_name": "activation of erythrocyte apoptotic process"}
{"concept_id": "C3821869", "aliases": [], "types": ["T043"], "canonical_name": "activation of RBC apoptosis"}
{"concept_id": "C3821870", "aliases": [], "types": ["T043"], "canonical_name": "activation of RBC apoptotic process"}
{"concept_id": "C3821871", "aliases": [], "types": ["T043"], "canonical_name": "activation of red blood cell apoptosis"}
{"concept_id": "C3821872", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of erythrocyte apoptosis"}
{"concept_id": "C3821873", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of RBC apoptosis"}
{"concept_id": "C3821874", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of red blood cell apoptosis"}
{"concept_id": "C3821875", "aliases": ["up-regulation of RBC apoptosis"], "types": ["T043"], "canonical_name": "up regulation of RBC apoptosis"}
{"concept_id": "C3821876", "aliases": ["up-regulation of red blood cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of red blood cell apoptosis"}
{"concept_id": "C3821877", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of erythrocyte apoptosis"}
{"concept_id": "C3821878", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of red blood cell apoptosis"}
{"concept_id": "C3821879", "aliases": ["regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator"], "types": ["T044"], "canonical_name": "regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "definition": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]"}
{"concept_id": "C3821880", "aliases": [], "types": ["T044"], "canonical_name": "regulation of signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821881", "aliases": ["inhibition of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator", "downregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator", "down-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator", "down regulation of signal transduction by p53 class mediator resulting in induction of apoptosis", "down regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator", "down-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis", "inhibition of intrinsic apoptotic signaling pathway by p53 class mediator", "downregulation of intrinsic apoptotic signaling pathway by p53 class mediator", "inhibition of signal transduction by p53 class mediator resulting in induction of apoptosis", "down-regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "down regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "negative regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator"], "types": ["T044"], "canonical_name": "negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]"}
{"concept_id": "C3821882", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821883", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821884", "aliases": ["up regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "upregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator", "up regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator", "positive regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator", "up-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator", "up-regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "upregulation of intrinsic apoptotic signaling pathway by p53 class mediator"], "types": ["T044"], "canonical_name": "positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "definition": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]"}
{"concept_id": "C3821885", "aliases": [], "types": ["T044"], "canonical_name": "activation of intrinsic apoptotic signaling pathway by p53 class mediator"}
{"concept_id": "C3821886", "aliases": [], "types": ["T044"], "canonical_name": "activation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator"}
{"concept_id": "C3821887", "aliases": [], "types": ["T044"], "canonical_name": "activation of signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821888", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821889", "aliases": ["up-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis"], "types": ["T044"], "canonical_name": "up regulation of signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821890", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of signal transduction by p53 class mediator resulting in induction of apoptosis"}
{"concept_id": "C3821891", "aliases": [], "types": ["T042"], "canonical_name": "regulation of apoptotic process involved in outflow tract morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]"}
{"concept_id": "C3821892", "aliases": [], "types": ["T042"], "canonical_name": "regulation of apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C3821893", "aliases": ["downregulation of apoptotic process involved in outflow tract morphogenesis", "down regulation of apoptotic process involved in outflow tract morphogenesis", "inhibition of apoptotic process involved in outflow tract morphogenesis", "down-regulation of apoptotic process involved in outflow tract morphogenesis"], "types": ["T042"], "canonical_name": "negative regulation of apoptotic process involved in outflow tract morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]"}
{"concept_id": "C3821894", "aliases": ["down-regulation of apoptosis involved in outflow tract morphogenesis"], "types": ["T042"], "canonical_name": "down regulation of apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C3821895", "aliases": [], "types": ["T042"], "canonical_name": "downregulation of apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C3821896", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C3821897", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C3821898", "aliases": ["activation of apoptotic process involved in outflow tract morphogenesis", "up-regulation of apoptotic process involved in outflow tract morphogenesis", "upregulation of apoptotic process involved in outflow tract morphogenesis", "up regulation of apoptotic process involved in outflow tract morphogenesis"], "types": ["T042"], "canonical_name": "positive regulation of apoptotic process involved in outflow tract morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]"}
{"concept_id": "C3821899", "aliases": [], "types": ["T042"], "canonical_name": "activation of apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C3821900", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C3821901", "aliases": ["up-regulation of apoptosis involved in outflow tract morphogenesis"], "types": ["T042"], "canonical_name": "up regulation of apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C3821902", "aliases": [], "types": ["T042"], "canonical_name": "upregulation of apoptosis involved in outflow tract morphogenesis"}
{"concept_id": "C3821903", "aliases": [], "types": ["T038"], "canonical_name": "regulation of delayed rectifier potassium channel activity", "definition": "Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204]"}
{"concept_id": "C3821904", "aliases": ["downregulation of delayed rectifier potassium channel activity", "down-regulation of delayed rectifier potassium channel activity", "down regulation of delayed rectifier potassium channel activity"], "types": ["T044"], "canonical_name": "negative regulation of delayed rectifier potassium channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11299204]"}
{"concept_id": "C3821905", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of delayed rectifier potassium channel activity"}
{"concept_id": "C3821906", "aliases": ["activation of delayed rectifier potassium channel activity", "upregulation of delayed rectifier potassium channel activity", "up-regulation of delayed rectifier potassium channel activity", "up regulation of delayed rectifier potassium channel activity"], "types": ["T038"], "canonical_name": "positive regulation of delayed rectifier potassium channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204]"}
{"concept_id": "C3821907", "aliases": ["apoptotic programmed cell death involved in patterning of blood vessels", "programmed cell death by apoptosis involved in patterning of blood vessels", "type I programmed cell death involved in patterning of blood vessels", "apoptotic cell death involved in patterning of blood vessels"], "types": ["T043"], "canonical_name": "apoptotic process involved in blood vessel morphogenesis", "definition": "Any apoptotic process that is involved in blood vessel morphogenesis. [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358]"}
{"concept_id": "C3821908", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in patterning of blood vessels"}
{"concept_id": "C3821909", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic program involved in patterning of blood vessels"}
{"concept_id": "C3821910", "aliases": [], "types": ["T043"], "canonical_name": "signaling (initiator) caspase activity involved in patterning of blood vessels"}
{"concept_id": "C3821911", "aliases": ["signaling (initiator) caspase activity involved in embryonic digit morphogenesis", "programmed cell death by apoptosis involved in embryonic digit morphogenesis", "apoptotic programmed cell death involved in embryonic digit morphogenesis", "apoptotic program involved in embryonic digit morphogenesis", "apoptotic cell death involved in embryonic digit morphogenesis"], "types": ["T043"], "canonical_name": "apoptotic process involved in embryonic digit morphogenesis", "definition": "Any apoptotic process that is involved in embryonic digit morphogenesis. [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:15967824]"}
{"concept_id": "C3821912", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in embryonic digit morphogenesis"}
{"concept_id": "C3821913", "aliases": [], "types": ["T043"], "canonical_name": "type I programmed cell death involved in embryonic digit morphogenesis"}
{"concept_id": "C3821914", "aliases": ["inhibition of regulation of Ran GTPase activity", "downregulation of regulation of Ran GTPase activity", "down-regulation of regulation of Ran GTPase activity", "negative regulation of Ran GTPase activity"], "types": ["T044"], "canonical_name": "down regulation of regulation of Ran GTPase activity"}
{"concept_id": "C3821915", "aliases": [], "types": ["T039"], "canonical_name": "abscisic acid homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of abscisic acid within an organism or cell. [GOC:TermGenie, PMID:23252460]"}
{"concept_id": "C3821916", "aliases": [], "types": ["T039"], "canonical_name": "2-cis-abscisate homeostasis"}
{"concept_id": "C3821917", "aliases": [], "types": ["T039"], "canonical_name": "ABA homeostasis"}
{"concept_id": "C3821918", "aliases": ["cellular 2-cis-abscisate homeostasis"], "types": ["T043"], "canonical_name": "cellular abscisic acid homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of abscisic acid at the level of the cell. [GOC:TermGenie, PMID:23252460]"}
{"concept_id": "C3821919", "aliases": [], "types": ["T043"], "canonical_name": "cellular ABA homeostasis"}
{"concept_id": "C3821920", "aliases": [], "types": ["T043"], "canonical_name": "regulation of polyamine transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of polyamine transmembrane transport. [GOC:TermGenie, PMID:23755272]"}
{"concept_id": "C3821921", "aliases": ["downregulation of polyamine transmembrane transport", "down-regulation of polyamine transmembrane transport", "down regulation of polyamine transmembrane transport"], "types": ["T043"], "canonical_name": "negative regulation of polyamine transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of polyamine transmembrane transport. [GOC:TermGenie, PMID:23755272]"}
{"concept_id": "C3821922", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of polyamine transmembrane transport"}
{"concept_id": "C3821923", "aliases": ["up regulation of polyamine transmembrane transport", "up-regulation of polyamine transmembrane transport", "upregulation of polyamine transmembrane transport"], "types": ["T043"], "canonical_name": "positive regulation of polyamine transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of polyamine transmembrane transport. [GOC:TermGenie, PMID:23755272]"}
{"concept_id": "C3821924", "aliases": [], "types": ["T043"], "canonical_name": "activation of polyamine transmembrane transport"}
{"concept_id": "C3821925", "aliases": [], "types": ["T043"], "canonical_name": "(R)-carnitine transmembrane transport", "definition": "The process in which (R)-carnitine is transported across a membrane. [GOC:TermGenie, PMID:23755272]"}
{"concept_id": "C3821926", "aliases": [], "types": ["T044"], "canonical_name": "D3 vitamins binding", "definition": "Binding to D3 vitamins. [GOC:bf, GOC:TermGenie, PMID:9127467]"}
{"concept_id": "C3821927", "aliases": [], "types": ["T043"], "canonical_name": "regulation of (R)-carnitine transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of (R)-carnitine transmembrane transport. [GOC:TermGenie, PMID:23755272]"}
{"concept_id": "C3821928", "aliases": ["inhibition of (R)-carnitine transmembrane transport", "down-regulation of (R)-carnitine transmembrane transport", "down regulation of (R)-carnitine transmembrane transport", "downregulation of (R)-carnitine transmembrane transport"], "types": ["T043"], "canonical_name": "negative regulation of (R)-carnitine transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of (R)-carnitine transmembrane transport. [GOC:TermGenie, PMID:23755272]"}
{"concept_id": "C3821929", "aliases": ["up regulation of (R)-carnitine transmembrane transport", "up-regulation of (R)-carnitine transmembrane transport", "upregulation of (R)-carnitine transmembrane transport"], "types": ["T043"], "canonical_name": "positive regulation of (R)-carnitine transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of (R)-carnitine transmembrane transport. [GOC:TermGenie, PMID:23755272]"}
{"concept_id": "C3821930", "aliases": [], "types": ["T043"], "canonical_name": "activation of (R)-carnitine transmembrane transport"}
{"concept_id": "C3821931", "aliases": ["regulation of establishment or maintenance of chromatin architecture", "regulation of chromatin organisation"], "types": ["T043"], "canonical_name": "regulation of chromatin organization", "definition": "Any process that modulates the frequency, rate or extent of chromatin organization. [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879]"}
{"concept_id": "C3821932", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pancreatic amylase secretion", "definition": "Any process that modulates the frequency, rate or extent of pancreatic amylase secretion. [GOC:jc, GOC:TermGenie]"}
{"concept_id": "C3821933", "aliases": ["downregulation of pancreatic amylase secretion", "down regulation of pancreatic amylase secretion", "down-regulation of pancreatic amylase secretion"], "types": ["T043"], "canonical_name": "negative regulation of pancreatic amylase secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic amylase secretion. [GOC:jc, GOC:TermGenie]"}
{"concept_id": "C3821934", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pancreatic amylase secretion"}
{"concept_id": "C3821935", "aliases": ["up regulation of pancreatic amylase secretion", "up-regulation of pancreatic amylase secretion", "upregulation of pancreatic amylase secretion"], "types": ["T043"], "canonical_name": "positive regulation of pancreatic amylase secretion", "definition": "Any process that activates or increases the frequency, rate or extent of pancreatic amylase secretion. [GOC:jc, GOC:TermGenie, PMID:19028687]"}
{"concept_id": "C3821936", "aliases": [], "types": ["T043"], "canonical_name": "activation of pancreatic amylase secretion"}
{"concept_id": "C3821937", "aliases": ["up regulation of pancreatic amylase secretion by cholecystokinin signaling pathway", "cholecystokinin-mediated pancreatic amylase secretion", "up-regulation of pancreatic amylase secretion by cholecystokinin signaling pathway", "CCK-induced amylase release in pancreatic cell", "upregulation of pancreatic amylase secretion by cholecystokinin signaling pathway", "CCK-stimulated pancreatic amylase release", "CCK-mediated pancreatic amylase secretion"], "types": ["T044"], "canonical_name": "positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway", "definition": "A cholecystokinin signaling pathway that results in positive regulation of pancreatic amylase secretion. [GOC:jc, GOC:TermGenie, PMID:19028687]"}
{"concept_id": "C3821938", "aliases": [], "types": ["T044"], "canonical_name": "activation of pancreatic amylase secretion by cholecystokinin signaling pathway"}
{"concept_id": "C3821939", "aliases": ["regulation of ATP-dependent RNA helicase activity"], "types": ["T044"], "canonical_name": "regulation of RNA helicase activity", "definition": "Any process that modulates the frequency, rate or extent of ATP-dependent RNA helicase activity. [GOC:rb, GOC:TermGenie, PMID:23721653]"}
{"concept_id": "C3821940", "aliases": ["down-regulation of ATP-dependent RNA helicase activity", "downregulation of ATP-dependent RNA helicase activity", "negative regulation of ATP-dependent RNA helicase activity", "down regulation of ATP-dependent RNA helicase activity"], "types": ["T044"], "canonical_name": "negative regulation of RNA helicase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent RNA helicase activity. [GOC:rb, GOC:TermGenie, PMID:23721653]"}
{"concept_id": "C3821941", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATP-dependent RNA helicase activity"}
{"concept_id": "C3821942", "aliases": ["voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential"], "types": ["T044"], "canonical_name": "voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "definition": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:8528244]"}
{"concept_id": "C3821943", "aliases": [], "types": ["T044"], "canonical_name": "voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential"}
{"concept_id": "C3821944", "aliases": ["negative regulation of primary-amine:oxygen oxidoreductase (deaminating) activity", "downregulation of primary-amine:oxygen oxidoreductase (deaminating) activity", "down-regulation of primary-amine:oxygen oxidoreductase (deaminating) activity", "down regulation of primary-amine:oxygen oxidoreductase (deaminating) activity", "down regulation of primary amine oxidase activity", "down-regulation of primary amine oxidase activity", "downregulation of primary amine oxidase activity"], "types": ["T044"], "canonical_name": "negative regulation of primary amine oxidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of primary amine oxidase activity. [GOC:TermGenie, PMID:23349812]"}
{"concept_id": "C3821945", "aliases": ["inhibition of amine oxidase (copper-containing) activity", "down-regulation of amine oxidase (copper-containing) activity"], "types": ["T044"], "canonical_name": "down regulation of amine oxidase (copper-containing) activity"}
{"concept_id": "C3821946", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of amine oxidase (copper-containing) activity"}
{"concept_id": "C3821947", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of primary amine oxidase activity"}
{"concept_id": "C3821948", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of primary-amine:oxygen oxidoreductase (deaminating) activity"}
{"concept_id": "C3821949", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of amine oxidase (copper-containing) activity"}
{"concept_id": "C3821950", "aliases": ["neuronal cell projection extension involved in neuronal cell projection guidance", "neuronal cell projection extension involved in neuron process guidance", "neuronal cell projection extension involved in neuron projection guidance", "neuron protrusion extension involved in neuron process guidance", "neuron projection extension involved in neuron protrusion guidance", "neuron process extension involved in neuron protrusion guidance", "neuron projection extension involved in neuron process guidance", "neuron projection extension involved in neurite guidance", "neuron protrusion extension involved in neuron projection guidance", "neuron process extension involved in neuronal cell projection guidance", "neuronal cell projection extension involved in neuron protrusion guidance", "neurite extension involved in neuron projection guidance", "neurite extension involved in neurite guidance", "neuron projection extension involved in neuronal cell projection guidance", "neuron protrusion extension involved in neuronal cell projection guidance", "neurite extension involved in neuron protrusion guidance", "neuron process extension involved in neuron projection guidance", "neuron protrusion extension involved in neurite guidance", "neuron process extension involved in neuron process guidance", "neuron protrusion extension involved in neuron protrusion guidance"], "types": ["T043"], "canonical_name": "neuron projection extension involved in neuron projection guidance", "definition": "Any neuron projection extension that is involved in neuron projection guidance. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]"}
{"concept_id": "C3821951", "aliases": ["neuron process extension involved in neurite guidance"], "types": ["T043"], "canonical_name": "neurite extension involved in neuron process guidance"}
{"concept_id": "C3821952", "aliases": ["neuronal cell projection extension involved in neurite guidance"], "types": ["T043"], "canonical_name": "neurite extension involved in neuronal cell projection guidance"}
{"concept_id": "C3821953", "aliases": ["semaphorin-plexin signaling pathway involved in neuron process guidance", "semaphorin-plexin signalling pathway involved in neuron projection guidance", "semaphorin-plexin signalling pathway involved in neuronal cell projection guidance", "semaphorin-plexin signaling pathway involved in neuron protrusion guidance", "semaphorin-plexin signalling pathway involved in neuron protrusion guidance", "semaphorin-plexin signaling pathway involved in neuronal cell projection guidance", "semaphorin-plexin signalling pathway involved in neuron process guidance"], "types": ["T044"], "canonical_name": "semaphorin-plexin signaling pathway involved in neuron projection guidance", "definition": "Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]"}
{"concept_id": "C3821954", "aliases": ["semaphorin-plexin signalling pathway involved in neurite guidance"], "types": ["T044"], "canonical_name": "semaphorin-plexin signaling pathway involved in neurite guidance"}
{"concept_id": "C3821955", "aliases": ["semaphorin-plexin signalling pathway involved in dendrite guidance", "semaphorin-plexin signalling pathway involved in dendritic guidance", "semaphorin-plexin signaling pathway involved in dendritic guidance"], "types": ["T044"], "canonical_name": "semaphorin-plexin signaling pathway involved in dendrite guidance", "definition": "Any semaphorin-plexin signaling pathway that is involved in dendrite guidance. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]"}
{"concept_id": "C3821956", "aliases": ["semaphorin-plexin signalling pathway involved in axon growth cone guidance", "semaphorin-plexin signalling pathway involved in axon guidance", "semaphorin-plexin signalling pathway involved in axon pathfinding", "semaphorin-plexin signaling pathway involved in axon pathfinding", "semaphorin-plexin signaling pathway involved in axon growth cone guidance"], "types": ["T044"], "canonical_name": "semaphorin-plexin signaling pathway involved in axon guidance", "definition": "Any semaphorin-plexin signaling pathway that is involved in axon guidance. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]"}
{"concept_id": "C3821957", "aliases": ["semaphorin-plexin signalling pathway involved in axon chemotaxis"], "types": ["T044"], "canonical_name": "semaphorin-plexin signaling pathway involved in axon chemotaxis"}
{"concept_id": "C3821958", "aliases": [], "types": ["T039"], "canonical_name": "regulation of defense response to oomycetes", "definition": "Any process that modulates the frequency, rate or extent of defense response to oomycetes. [GOC:TermGenie, PMID:16040633]"}
{"concept_id": "C3821959", "aliases": ["down regulation of defense response to oomycetes", "down-regulation of defense response to oomycetes", "downregulation of defense response to oomycetes"], "types": ["T039"], "canonical_name": "negative regulation of defense response to oomycetes", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to oomycetes. [GOC:TermGenie, PMID:16040633]"}
{"concept_id": "C3821960", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of defense response to oomycetes"}
{"concept_id": "C3821961", "aliases": ["activation of defense response to oomycetes", "upregulation of defense response to oomycetes", "up regulation of defense response to oomycetes", "up-regulation of defense response to oomycetes"], "types": ["T039"], "canonical_name": "positive regulation of defense response to oomycetes", "definition": "Any process that activates or increases the frequency, rate or extent of defense response to oomycetes. [GOC:TermGenie, PMID:16040633]"}
{"concept_id": "C3821962", "aliases": ["DNA ligation involved in cell cycle DNA replication"], "types": ["T045"], "canonical_name": "cell cycle DNA replication DNA ligation", "definition": "Any DNA ligation that is involved in cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821963", "aliases": ["DNA-dependent DNA replication initiation involved in cell cycle DNA replication", "DNA replication initiation involved in cell cycle DNA replication"], "types": ["T045"], "canonical_name": "cell cycle DNA replication initiation", "definition": "Any DNA replication initiation that is involved in cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821964", "aliases": [], "types": ["T045"], "canonical_name": "DNA endoreduplication initiation involved in cell cycle DNA replication"}
{"concept_id": "C3821965", "aliases": [], "types": ["T045"], "canonical_name": "DNA re-replication initiation involved in cell cycle DNA replication"}
{"concept_id": "C3821966", "aliases": ["DNA replication termination involved in cell cycle DNA replication"], "types": ["T045"], "canonical_name": "cell cycle DNA replication termination", "definition": "Any DNA replication termination that is involved in cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821967", "aliases": ["DNA replication, synthesis of RNA primer involved in cell cycle DNA replication"], "types": ["T045"], "canonical_name": "synthesis of RNA primer involved in cell cycle DNA replication", "definition": "Any DNA replication, synthesis of RNA primer that is involved in cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821968", "aliases": [], "types": ["T045"], "canonical_name": "replication priming involved in cell cycle DNA replication"}
{"concept_id": "C3821969", "aliases": ["DNA replication elongation involved in cell cycle DNA replication"], "types": ["T045"], "canonical_name": "DNA strand elongation involved in cell cycle DNA replication", "definition": "Any DNA strand elongation that is involved in cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821970", "aliases": [], "types": ["T045"], "canonical_name": "DNA strand elongation during DNA replication involved in cell cycle DNA replication"}
{"concept_id": "C3821971", "aliases": ["DNA unwinding involved in cell cycle DNA replication"], "types": ["T045"], "canonical_name": "cell cycle DNA replication DNA unwinding", "definition": "Any DNA unwinding that is involved in cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821972", "aliases": [], "types": ["T045"], "canonical_name": "DNA unwinding during replication involved in cell cycle DNA replication"}
{"concept_id": "C3821973", "aliases": [], "types": ["T045"], "canonical_name": "DNA unwinding factor involved in cell cycle DNA replication"}
{"concept_id": "C3821974", "aliases": ["maintenance of fidelity involved in cell cycle DNA replication"], "types": ["T045"], "canonical_name": "cell cycle DNA replication maintenance of fidelity", "definition": "Any maintenance of fidelity that is involved in cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821975", "aliases": [], "types": ["T045"], "canonical_name": "maintenance of fidelity during DNA-dependent DNA replication involved in cell cycle DNA replication"}
{"concept_id": "C3821976", "aliases": ["pre-RC assembly involved in cell cycle DNA replication"], "types": ["T044"], "canonical_name": "pre-replicative complex assembly involved in cell cycle DNA replication", "definition": "Any pre-replicative complex assembly that is involved in cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3821977", "aliases": [], "types": ["T044"], "canonical_name": "pre-replication complex assembly involved in cell cycle DNA replication"}
{"concept_id": "C3821978", "aliases": ["galactarate transport", "galactaric acid anion transport"], "types": ["T043"], "canonical_name": "galactarate transmembrane transport", "definition": "The process in which galactaric acid anion (galactarate) is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3821979", "aliases": ["galactaric acid anion transmembrane transporter activity"], "types": ["T044"], "canonical_name": "galactarate transmembrane transporter activity", "definition": "Enables the transfer of galactaric acid anion (galactarate) from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3821980", "aliases": ["regulation of potassium ion export"], "types": ["T043"], "canonical_name": "regulation of potassium export"}
{"concept_id": "C3821981", "aliases": ["downregulation of potassium export", "down-regulation of potassium export", "down regulation of potassium ion export", "down-regulation of potassium ion export", "downregulation of potassium ion export", "negative regulation of potassium ion export", "negative regulation of potassium export"], "types": ["T043"], "canonical_name": "down regulation of potassium export"}
{"concept_id": "C3821982", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of potassium export"}
{"concept_id": "C3821983", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of potassium ion export"}
{"concept_id": "C3821984", "aliases": ["positive regulation of potassium ion export", "upregulation of potassium ion export", "up regulation of potassium export", "up-regulation of potassium ion export", "up regulation of potassium ion export", "up-regulation of potassium export", "upregulation of potassium export"], "types": ["T043"], "canonical_name": "positive regulation of potassium export"}
{"concept_id": "C3821985", "aliases": [], "types": ["T043"], "canonical_name": "activation of potassium export"}
{"concept_id": "C3821986", "aliases": [], "types": ["T043"], "canonical_name": "activation of potassium ion export"}
{"concept_id": "C3821987", "aliases": ["regulation of sodium ion membrane transport"], "types": ["T043"], "canonical_name": "regulation of sodium ion transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]"}
{"concept_id": "C3821988", "aliases": ["down-regulation of sodium ion transmembrane transport", "down regulation of sodium ion membrane transport", "down-regulation of sodium ion membrane transport", "down regulation of sodium ion transmembrane transport", "downregulation of sodium ion transmembrane transport", "negative regulation of sodium ion membrane transport", "downregulation of sodium ion membrane transport"], "types": ["T043"], "canonical_name": "negative regulation of sodium ion transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]"}
{"concept_id": "C3821989", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sodium ion membrane transport"}
{"concept_id": "C3821990", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sodium ion transmembrane transport"}
{"concept_id": "C3821991", "aliases": ["upregulation of sodium ion transmembrane transport", "up regulation of sodium ion transmembrane transport", "up regulation of sodium ion membrane transport", "positive regulation of sodium ion membrane transport", "up-regulation of sodium ion membrane transport", "up-regulation of sodium ion transmembrane transport", "upregulation of sodium ion membrane transport"], "types": ["T043"], "canonical_name": "positive regulation of sodium ion transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]"}
{"concept_id": "C3821992", "aliases": [], "types": ["T043"], "canonical_name": "activation of sodium ion membrane transport"}
{"concept_id": "C3821993", "aliases": [], "types": ["T043"], "canonical_name": "activation of sodium ion transmembrane transport"}
{"concept_id": "C3821994", "aliases": [], "types": ["T044"], "canonical_name": "regulation of peptidyl-serine dephosphorylation", "definition": "Any process that modulates the frequency, rate or extent of peptidyl-serine dephosphorylation. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308]"}
{"concept_id": "C3821995", "aliases": ["inhibition of peptidyl-serine dephosphorylation", "down regulation of peptidyl-serine dephosphorylation", "downregulation of peptidyl-serine dephosphorylation", "down-regulation of peptidyl-serine dephosphorylation"], "types": ["T044"], "canonical_name": "negative regulation of peptidyl-serine dephosphorylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308]"}
{"concept_id": "C3821996", "aliases": ["up regulation of peptidyl-serine dephosphorylation", "upregulation of peptidyl-serine dephosphorylation", "up-regulation of peptidyl-serine dephosphorylation"], "types": ["T044"], "canonical_name": "positive regulation of peptidyl-serine dephosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308]"}
{"concept_id": "C3821997", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptidyl-serine dephosphorylation"}
{"concept_id": "C3821998", "aliases": ["regulation of copper cation transmembrane transport", "regulation of copper ion membrane transport"], "types": ["T043"], "canonical_name": "regulation of copper ion transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of copper ion transmembrane transport. [GOC:di, GOC:TermGenie, PMID:21489137]"}
{"concept_id": "C3821999", "aliases": ["downregulation of copper ion transmembrane transport", "down-regulation of copper ion membrane transport", "down-regulation of copper cation transmembrane transport", "negative regulation of copper ion membrane transport", "inhibition of copper cation transmembrane transport", "downregulation of copper ion membrane transport", "downregulation of copper cation transmembrane transport", "down regulation of copper cation transmembrane transport", "down regulation of copper ion membrane transport", "negative regulation of copper cation transmembrane transport", "down-regulation of copper ion transmembrane transport", "down regulation of copper ion transmembrane transport"], "types": ["T043"], "canonical_name": "negative regulation of copper ion transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of copper ion transmembrane transport. [GOC:di, GOC:TermGenie, PMID:21489137]"}
{"concept_id": "C3822000", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of copper ion membrane transport"}
{"concept_id": "C3822001", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of copper ion transmembrane transport"}
{"concept_id": "C3822002", "aliases": ["up-regulation of copper ion membrane transport", "up-regulation of copper cation transmembrane transport", "upregulation of copper ion transmembrane transport", "activation of copper cation transmembrane transport", "up-regulation of copper ion transmembrane transport", "upregulation of copper ion membrane transport", "up regulation of copper ion membrane transport", "up regulation of copper cation transmembrane transport", "positive regulation of copper ion membrane transport", "up regulation of copper ion transmembrane transport", "positive regulation of copper cation transmembrane transport", "upregulation of copper cation transmembrane transport"], "types": ["T043"], "canonical_name": "positive regulation of copper ion transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of copper ion transmembrane transport. [GOC:di, GOC:TermGenie, PMID:21489137]"}
{"concept_id": "C3822003", "aliases": [], "types": ["T043"], "canonical_name": "activation of copper ion membrane transport"}
{"concept_id": "C3822004", "aliases": [], "types": ["T043"], "canonical_name": "activation of copper ion transmembrane transport"}
{"concept_id": "C3822005", "aliases": ["quinol binding"], "types": ["T044"], "canonical_name": "hydroquinone binding", "definition": "Binding to hydroquinone. [GOC:bhm, GOC:TermGenie, pmid:15667223]"}
{"concept_id": "C3822006", "aliases": ["DNA replication initiation involved in nuclear cell cycle DNA replication"], "types": ["T045"], "canonical_name": "nuclear cell cycle DNA replication initiation", "definition": "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822007", "aliases": [], "types": ["T045"], "canonical_name": "DNA endoreduplication initiation involved in nuclear cell cycle DNA replication"}
{"concept_id": "C3822008", "aliases": [], "types": ["T045"], "canonical_name": "DNA re-replication initiation involved in nuclear cell cycle DNA replication"}
{"concept_id": "C3822009", "aliases": ["DNA replication termination involved in DNA replication involved in S phase", "DNA replication termination involved in nuclear cell cycle DNA replication", "DNA replication termination involved in DNA replication involved in S-phase"], "types": ["T045"], "canonical_name": "nuclear DNA replication termination", "definition": "Any DNA replication termination that is involved in nuclear cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822010", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication termination involved in DNA replication during S phase"}
{"concept_id": "C3822011", "aliases": ["DNA replication, synthesis of RNA primer involved in DNA replication involved in S-phase", "DNA replication, synthesis of RNA primer involved in DNA replication involved in S phase"], "types": ["T045"], "canonical_name": "synthesis of RNA primer involved in nuclear cell cycle DNA replication", "definition": "Any synthesis of RNA primer that is involved in nuclear cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822012", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication, synthesis of RNA primer involved in DNA replication during S phase"}
{"concept_id": "C3822013", "aliases": ["replication priming involved in DNA replication involved in S-phase", "replication priming involved in DNA replication involved in S phase"], "types": ["T045"], "canonical_name": "replication priming involved in DNA replication during S phase"}
{"concept_id": "C3822014", "aliases": [], "types": ["T045"], "canonical_name": "replication priming involved in nuclear cell cycle DNA replication"}
{"concept_id": "C3822015", "aliases": ["DNA strand elongation involved in DNA replication involved in S-phase", "DNA strand elongation involved in DNA replication involved in S phase"], "types": ["T045"], "canonical_name": "DNA strand elongation involved in nuclear cell cycle DNA replication", "definition": "Any DNA strand elongation that is involved in nuclear cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822016", "aliases": [], "types": ["T045"], "canonical_name": "DNA strand elongation involved in DNA replication during S phase"}
{"concept_id": "C3822017", "aliases": ["DNA duplex unwinding involved in DNA replication involved in S-phase", "duplex DNA melting involved in DNA replication involved in S-phase", "DNA unwinding involved in DNA replication involved in S phase", "DNA duplex unwinding involved in DNA replication involved in S phase", "DNA unwinding involved in DNA replication involved in S-phase", "DNA duplex unwinding involved in nuclear cell cycle DNA replication", "DNA unwinding involved in nuclear cell cycle DNA replication", "duplex DNA melting involved in DNA replication involved in S phase"], "types": ["T045"], "canonical_name": "nuclear DNA replication DNA duplex unwinding", "definition": "Any DNA duplex unwinding that is involved in nuclear cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822018", "aliases": [], "types": ["T045"], "canonical_name": "DNA duplex unwinding involved in DNA replication during S phase"}
{"concept_id": "C3822019", "aliases": [], "types": ["T045"], "canonical_name": "DNA unwinding involved in DNA replication during S phase"}
{"concept_id": "C3822020", "aliases": [], "types": ["T045"], "canonical_name": "duplex DNA melting involved in DNA replication during S phase"}
{"concept_id": "C3822021", "aliases": ["methyl-branched fatty acid formation", "methyl-branched fatty acid biosynthesis", "methyl-branched fatty acid anabolism", "methyl-branched fatty acid synthesis"], "types": ["T044"], "canonical_name": "methyl-branched fatty acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of methyl-branched fatty acid. [GOC:kmv, GOC:TermGenie, PMID:15340492]"}
{"concept_id": "C3822022", "aliases": ["regulation of methyl-branched fatty acid synthesis", "regulation of methyl-branched fatty acid biosynthesis", "regulation of methyl-branched fatty acid anabolism", "regulation of methyl-branched fatty acid formation"], "types": ["T043"], "canonical_name": "regulation of methyl-branched fatty acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of methyl-branched fatty acid biosynthetic process. [GOC:kmv, GOC:TermGenie, PMID:15340492]"}
{"concept_id": "C3822023", "aliases": ["downregulation of methyl-branched fatty acid formation", "down regulation of methyl-branched fatty acid synthesis", "negative regulation of methyl-branched fatty acid biosynthesis", "down regulation of methyl-branched fatty acid anabolism", "downregulation of methyl-branched fatty acid biosynthesis", "down regulation of methyl-branched fatty acid biosynthesis", "down regulation of methyl-branched fatty acid formation", "negative regulation of methyl-branched fatty acid formation", "negative regulation of methyl-branched fatty acid synthesis", "downregulation of methyl-branched fatty acid biosynthetic process", "down-regulation of methyl-branched fatty acid biosynthetic process", "down-regulation of methyl-branched fatty acid formation", "inhibition of methyl-branched fatty acid synthesis", "downregulation of methyl-branched fatty acid synthesis", "downregulation of methyl-branched fatty acid anabolism", "down-regulation of methyl-branched fatty acid biosynthesis", "negative regulation of methyl-branched fatty acid anabolism", "down regulation of methyl-branched fatty acid biosynthetic process", "down-regulation of methyl-branched fatty acid anabolism", "down-regulation of methyl-branched fatty acid synthesis"], "types": ["T043"], "canonical_name": "negative regulation of methyl-branched fatty acid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methyl-branched fatty acid biosynthetic process. [GOC:kmv, GOC:TermGenie, PMID:15340492]"}
{"concept_id": "C3822024", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of methyl-branched fatty acid anabolism"}
{"concept_id": "C3822025", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of methyl-branched fatty acid biosynthesis"}
{"concept_id": "C3822026", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of methyl-branched fatty acid biosynthetic process"}
{"concept_id": "C3822027", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of methyl-branched fatty acid formation"}
{"concept_id": "C3822028", "aliases": ["upregulation of methyl-branched fatty acid formation", "up-regulation of methyl-branched fatty acid biosynthesis", "positive regulation of methyl-branched fatty acid biosynthesis", "upregulation of methyl-branched fatty acid anabolism", "up-regulation of methyl-branched fatty acid biosynthetic process", "up regulation of methyl-branched fatty acid anabolism", "up regulation of methyl-branched fatty acid synthesis", "up-regulation of methyl-branched fatty acid synthesis", "up regulation of methyl-branched fatty acid biosynthesis", "upregulation of methyl-branched fatty acid biosynthesis", "upregulation of methyl-branched fatty acid biosynthetic process", "positive regulation of methyl-branched fatty acid anabolism", "up-regulation of methyl-branched fatty acid anabolism", "positive regulation of methyl-branched fatty acid synthesis", "up-regulation of methyl-branched fatty acid formation", "upregulation of methyl-branched fatty acid synthesis", "up regulation of methyl-branched fatty acid formation", "up regulation of methyl-branched fatty acid biosynthetic process", "positive regulation of methyl-branched fatty acid formation"], "types": ["T043"], "canonical_name": "positive regulation of methyl-branched fatty acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of methyl-branched fatty acid biosynthetic process. [GOC:kmv, GOC:TermGenie, PMID:15340492]"}
{"concept_id": "C3822029", "aliases": [], "types": ["T043"], "canonical_name": "activation of methyl-branched fatty acid anabolism"}
{"concept_id": "C3822030", "aliases": [], "types": ["T043"], "canonical_name": "activation of methyl-branched fatty acid biosynthesis"}
{"concept_id": "C3822031", "aliases": [], "types": ["T043"], "canonical_name": "activation of methyl-branched fatty acid biosynthetic process"}
{"concept_id": "C3822032", "aliases": [], "types": ["T043"], "canonical_name": "activation of methyl-branched fatty acid formation"}
{"concept_id": "C3822033", "aliases": [], "types": ["T043"], "canonical_name": "activation of methyl-branched fatty acid synthesis"}
{"concept_id": "C3822034", "aliases": ["down regulation of chlorophyll anabolism", "downregulation of chlorophyll biosynthesis", "negative regulation of chlorophyll synthesis", "down regulation of chlorophyll biosynthesis", "downregulation of chlorophyll anabolism", "negative regulation of chlorophyll biosynthesis", "down regulation of chlorophyll synthesis", "down-regulation of chlorophyll anabolism", "downregulation of chlorophyll formation", "negative regulation of chlorophyll formation", "down regulation of chlorophyll formation", "down-regulation of chlorophyll biosynthetic process", "inhibition of chlorophyll biosynthesis", "down-regulation of chlorophyll biosynthesis", "down-regulation of chlorophyll synthesis", "down-regulation of chlorophyll formation", "downregulation of chlorophyll biosynthetic process", "downregulation of chlorophyll synthesis", "down regulation of chlorophyll biosynthetic process", "negative regulation of chlorophyll anabolism"], "types": ["T044"], "canonical_name": "negative regulation of chlorophyll biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll biosynthetic process. [GOC:TermGenie, PMID:23555952]"}
{"concept_id": "C3822035", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of chlorophyll anabolism"}
{"concept_id": "C3822036", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of chlorophyll biosynthetic process"}
{"concept_id": "C3822037", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of chlorophyll formation"}
{"concept_id": "C3822038", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of chlorophyll synthesis"}
{"concept_id": "C3822039", "aliases": ["positive regulation of chlorophyll biosynthesis", "upregulation of chlorophyll formation", "up regulation of chlorophyll biosynthetic process", "up regulation of chlorophyll formation", "up-regulation of chlorophyll biosynthesis", "up-regulation of chlorophyll synthesis", "up regulation of chlorophyll synthesis", "upregulation of chlorophyll anabolism", "up-regulation of chlorophyll biosynthetic process", "up-regulation of chlorophyll formation", "up-regulation of chlorophyll anabolism", "positive regulation of chlorophyll formation", "upregulation of chlorophyll biosynthetic process", "up regulation of chlorophyll anabolism", "upregulation of chlorophyll biosynthesis", "positive regulation of chlorophyll anabolism", "positive regulation of chlorophyll synthesis", "up regulation of chlorophyll biosynthesis", "upregulation of chlorophyll synthesis"], "types": ["T044"], "canonical_name": "positive regulation of chlorophyll biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of chlorophyll biosynthetic process. [GOC:TermGenie, PMID:23555952]"}
{"concept_id": "C3822040", "aliases": [], "types": ["T044"], "canonical_name": "activation of chlorophyll anabolism"}
{"concept_id": "C3822041", "aliases": [], "types": ["T044"], "canonical_name": "activation of chlorophyll biosynthesis"}
{"concept_id": "C3822042", "aliases": [], "types": ["T044"], "canonical_name": "activation of chlorophyll biosynthetic process"}
{"concept_id": "C3822043", "aliases": [], "types": ["T044"], "canonical_name": "activation of chlorophyll formation"}
{"concept_id": "C3822044", "aliases": [], "types": ["T044"], "canonical_name": "activation of chlorophyll synthesis"}
{"concept_id": "C3822045", "aliases": ["DNA ligation involved in bacterial-type DNA replication"], "types": ["T045"], "canonical_name": "bacterial-type DNA replication DNA ligation", "definition": "Any DNA ligation that is involved in bacterial-type DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822046", "aliases": ["DNA replication initiation involved in bacterial-type DNA replication", "DNA-dependent DNA replication initiation involved in bacterial-type DNA replication"], "types": ["T045"], "canonical_name": "bacterial-type DNA replication initiation", "definition": "Any DNA replication initiation that is involved in bacterial-type DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822047", "aliases": [], "types": ["T045"], "canonical_name": "DNA endoreduplication initiation involved in bacterial-type DNA replication"}
{"concept_id": "C3822048", "aliases": [], "types": ["T045"], "canonical_name": "DNA re-replication initiation involved in bacterial-type DNA replication"}
{"concept_id": "C3822049", "aliases": ["DNA replication termination involved in bacterial-type DNA replication"], "types": ["T045"], "canonical_name": "bacterial-type DNA replication termination", "definition": "Any DNA replication termination that is involved in bacterial-type DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822050", "aliases": [], "types": ["T045"], "canonical_name": "synthesis of RNA primer involved in bacterial-type DNA replication", "definition": "Any synthesis of RNA primer that is involved in bacterial-type DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822051", "aliases": [], "types": ["T045"], "canonical_name": "replication priming involved in bacterial-type DNA replication"}
{"concept_id": "C3822053", "aliases": ["duplex DNA melting involved in bacterial-type DNA replication", "DNA unwinding involved in bacterial-type DNA replication", "DNA duplex unwinding involved in bacterial-type DNA replication"], "types": ["T045"], "canonical_name": "bacterial-type DNA replication DNA duplex unwinding", "definition": "Any DNA duplex unwinding that is involved in bacterial-type DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822054", "aliases": ["DNA ligation involved in DNA replication involved in S phase", "DNA ligation involved in DNA replication involved in S-phase", "DNA ligation involved in nuclear cell cycle DNA replication"], "types": ["T045"], "canonical_name": "nuclear DNA replication DNA ligation", "definition": "Any DNA ligation that is involved in nuclear cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822055", "aliases": [], "types": ["T045"], "canonical_name": "DNA ligation involved in DNA replication during S phase"}
{"concept_id": "C3822056", "aliases": ["fructose transport from vacuole to cytoplasm"], "types": ["T043"], "canonical_name": "fructose export from vacuole to cytoplasm", "definition": "The directed movement of fructose from vacuole to cytoplasm. [GOC:TermGenie, PMID:23583552]"}
{"concept_id": "C3822060", "aliases": ["positive regulation of retinal ganglion cell axon pathfinding", "up-regulation of retinal ganglion cell axon guidance", "up regulation of retinal ganglion cell axon guidance", "upregulation of retinal ganglion cell axon pathfinding", "upregulation of retinal ganglion cell axon guidance", "up regulation of retinal ganglion cell axon pathfinding", "up-regulation of retinal ganglion cell axon pathfinding"], "types": ["T042"], "canonical_name": "positive regulation of retinal ganglion cell axon guidance", "definition": "Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]"}
{"concept_id": "C3822061", "aliases": [], "types": ["T042"], "canonical_name": "activation of retinal ganglion cell axon guidance"}
{"concept_id": "C3822062", "aliases": [], "types": ["T042"], "canonical_name": "activation of retinal ganglion cell axon pathfinding"}
{"concept_id": "C3822063", "aliases": ["regulation of morphogenetic apoptosis"], "types": ["T043"], "canonical_name": "regulation of apoptotic process involved in morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis. [GOC:sart, GOC:TermGenie, PMID:12202035]"}
{"concept_id": "C3822064", "aliases": [], "types": ["T038"], "canonical_name": "regulation of apoptosis involved in development"}
{"concept_id": "C3822065", "aliases": [], "types": ["T038"], "canonical_name": "regulation of apoptosis involved in morphogenesis"}
{"concept_id": "C3822066", "aliases": ["negative regulation of morphogenetic apoptosis", "inhibition of morphogenetic apoptosis", "downregulation of apoptotic process involved in morphogenesis", "down regulation of apoptotic process involved in morphogenesis", "down-regulation of apoptotic process involved in morphogenesis"], "types": ["T043"], "canonical_name": "negative regulation of apoptotic process involved in morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis. [GOC:sart, GOC:TermGenie, PMID:12202035]"}
{"concept_id": "C3822067", "aliases": ["down-regulation of apoptosis involved in development"], "types": ["T043"], "canonical_name": "down regulation of apoptosis involved in development"}
{"concept_id": "C3822068", "aliases": ["down-regulation of apoptosis involved in morphogenesis"], "types": ["T043"], "canonical_name": "down regulation of apoptosis involved in morphogenesis"}
{"concept_id": "C3822069", "aliases": ["down-regulation of morphogenetic apoptosis"], "types": ["T043"], "canonical_name": "down regulation of morphogenetic apoptosis"}
{"concept_id": "C3822070", "aliases": ["inhibition of apoptosis involved in development", "negative regulation of apoptosis involved in development"], "types": ["T043"], "canonical_name": "downregulation of apoptosis involved in development"}
{"concept_id": "C3822071", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of apoptosis involved in morphogenesis"}
{"concept_id": "C3822072", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of morphogenetic apoptosis"}
{"concept_id": "C3822073", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis involved in morphogenesis"}
{"concept_id": "C3822074", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic process involved in morphogenesis"}
{"concept_id": "C3822075", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptosis involved in morphogenesis"}
{"concept_id": "C3822076", "aliases": ["up-regulation of apoptosis involved in morphogenesis", "positive regulation of apoptosis involved in morphogenesis", "up regulation of apoptosis involved in development", "up-regulation of apoptotic process involved in morphogenesis", "up regulation of apoptosis involved in morphogenesis", "up-regulation of apoptosis involved in development", "up regulation of apoptotic process involved in morphogenesis", "upregulation of apoptotic process involved in morphogenesis", "upregulation of morphogenetic apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of apoptotic process involved in morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis. [GOC:sart, GOC:TermGenie, PMID:12202035]"}
{"concept_id": "C3822077", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptosis involved in development"}
{"concept_id": "C3822078", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptosis involved in morphogenesis"}
{"concept_id": "C3822079", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic process involved in morphogenesis"}
{"concept_id": "C3822080", "aliases": [], "types": ["T043"], "canonical_name": "activation of morphogenetic apoptosis"}
{"concept_id": "C3822081", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptosis involved in development"}
{"concept_id": "C3822082", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of morphogenetic apoptosis"}
{"concept_id": "C3822083", "aliases": ["up-regulation of morphogenetic apoptosis"], "types": ["T043"], "canonical_name": "up regulation of morphogenetic apoptosis"}
{"concept_id": "C3822084", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of apoptosis involved in development"}
{"concept_id": "C3822085", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of apoptosis involved in morphogenesis"}
{"concept_id": "C3822086", "aliases": ["negative regulation of nuclear chromosome condensation", "downregulation of chromosome condensation", "down-regulation of chromosome condensation", "down regulation of eukaryotic chromosome condensation", "down-regulation of eukaryotic chromosome condensation", "down-regulation of nuclear chromosome condensation", "downregulation of nuclear chromosome condensation", "down regulation of chromosome condensation", "down regulation of nuclear chromosome condensation", "downregulation of eukaryotic chromosome condensation", "negative regulation of eukaryotic chromosome condensation"], "types": ["T045"], "canonical_name": "negative regulation of chromosome condensation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. [GOC:TermGenie, PMID:23219725]"}
{"concept_id": "C3822087", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of chromosome condensation"}
{"concept_id": "C3822088", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of eukaryotic chromosome condensation"}
{"concept_id": "C3822089", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of nuclear chromosome condensation"}
{"concept_id": "C3822090", "aliases": [], "types": ["T043"], "canonical_name": "xylitol transport"}
{"concept_id": "C3822092", "aliases": [], "types": ["T043"], "canonical_name": "regulation of maltose transport", "definition": "Any process that modulates the frequency, rate or extent of maltose transport. [GOC:dph, GOC:TermGenie, PMID:23770568]"}
{"concept_id": "C3822093", "aliases": ["down regulation of maltose transport", "downregulation of maltose transport", "down-regulation of maltose transport"], "types": ["T043"], "canonical_name": "negative regulation of maltose transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maltose transport. [GOC:dph, GOC:TermGenie, PMID:23770568]"}
{"concept_id": "C3822094", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maltose transport"}
{"concept_id": "C3822095", "aliases": ["up-regulation of maltose transport", "upregulation of maltose transport", "up regulation of maltose transport"], "types": ["T043"], "canonical_name": "positive regulation of maltose transport", "definition": "Any process that activates or increases the frequency, rate or extent of maltose transport. [GOC:dph, GOC:TermGenie, PMID:23770568]"}
{"concept_id": "C3822096", "aliases": [], "types": ["T043"], "canonical_name": "activation of maltose transport"}
{"concept_id": "C3822097", "aliases": ["meiotic strand displacement involved in double-strand break repair via synthesis-dependent strand annealing"], "types": ["T045"], "canonical_name": "meiotic strand displacement involved in double-strand break repair via SDSA", "definition": "Any meiotic strand displacement that is involved in double-strand break repair via synthesis-dependent strand annealing (SDSA). [GOC:al, GOC:TermGenie, PMID:22723423]"}
{"concept_id": "C3822098", "aliases": [], "types": ["T045"], "canonical_name": "meiotic D-loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing"}
{"concept_id": "C3822099", "aliases": [], "types": ["T045"], "canonical_name": "meiotic D-loop dissociation involved in mitotic gene conversion"}
{"concept_id": "C3822100", "aliases": [], "types": ["T045"], "canonical_name": "meiotic D-loop processing involved in double-strand break repair via synthesis-dependent strand annealing"}
{"concept_id": "C3822101", "aliases": [], "types": ["T045"], "canonical_name": "meiotic D-loop processing involved in mitotic gene conversion"}
{"concept_id": "C3822102", "aliases": [], "types": ["T045"], "canonical_name": "meiotic displacement loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing"}
{"concept_id": "C3822103", "aliases": [], "types": ["T045"], "canonical_name": "meiotic displacement loop dissociation involved in mitotic gene conversion"}
{"concept_id": "C3822104", "aliases": [], "types": ["T045"], "canonical_name": "meiotic displacement loop processing involved in double-strand break repair via synthesis-dependent strand annealing"}
{"concept_id": "C3822105", "aliases": [], "types": ["T045"], "canonical_name": "meiotic displacement loop processing involved in mitotic gene conversion"}
{"concept_id": "C3822106", "aliases": [], "types": ["T045"], "canonical_name": "meiotic strand displacement involved in mitotic gene conversion"}
{"concept_id": "C3822107", "aliases": [], "types": ["T045"], "canonical_name": "meiotic strand displacement involved in SDSA"}
{"concept_id": "C3822108", "aliases": ["response to strigolactone analog GR24"], "types": ["T043"], "canonical_name": "response to strigolactone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus. [GOC:TermGenie, PMID:23893171]"}
{"concept_id": "C3822109", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to strigolactone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus. [GOC:TermGenie, PMID:23893171]"}
{"concept_id": "C3822110", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to strigolactone analog GR24"}
{"concept_id": "C3822111", "aliases": [], "types": ["T043"], "canonical_name": "response to chloroquine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus. [GOC:kmv, GOC:TermGenie, PMID:23922869]"}
{"concept_id": "C3822112", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chloroquine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus. [GOC:kmv, GOC:TermGenie, PMID:23922869]"}
{"concept_id": "C3822113", "aliases": [], "types": ["T043"], "canonical_name": "response to imidacloprid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an imidacloprid stimulus. [GOC:kmv, GOC:TermGenie, PMID:23922869]"}
{"concept_id": "C3822116", "aliases": [], "types": ["T043"], "canonical_name": "blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment", "definition": "Any blood vessel endothelial cell delamination that is involved in blood vessel lumen ensheathment. [GOC:dgh, GOC:TermGenie, PMID:23698350]"}
{"concept_id": "C3822117", "aliases": [], "types": ["T042"], "canonical_name": "endothelial tube lumen extension involved in blood vessel lumen ensheathment", "definition": "Any endothelial tube lumen extension that is involved in blood vessel lumen ensheathment. [GOC:dgh, GOC:TermGenie, PMID:23698350]"}
{"concept_id": "C3822118", "aliases": [], "types": ["T043"], "canonical_name": "oxaloacetate(2-) transmembrane transport", "definition": "The directed movement of oxaloacetate(2-) across a membrane. [GOC:dph, GOC:TermGenie, PMID:18682385]"}
{"concept_id": "C3822119", "aliases": [], "types": ["T043"], "canonical_name": "2-isopropylmalate(2-) transmembrane transport", "definition": "The process in which 2-isopropylmalate(2-) is transported across a membrane. [GOC:dph, GOC:TermGenie, GOC:vw, PMID:18682385]"}
{"concept_id": "C3822120", "aliases": [], "types": ["T043"], "canonical_name": "sulfate transmembrane transport", "definition": "The directed movement of sulfate across a membrane. [GOC:dph, GOC:TermGenie, PMID:9055073]"}
{"concept_id": "C3822121", "aliases": ["Notch-receptor signalling pathway involved in somitogenesis", "Notch receptor signalling pathway involved in formation of mesodermal clusters", "N signaling pathway involved in somitogenesis", "Notch-receptor signaling pathway involved in formation of mesodermal clusters", "N signalling pathway involved in formation of mesodermal clusters", "Notch signalling pathway involved in somitogenesis", "Notch-receptor signalling pathway involved in formation of mesodermal clusters", "Notch receptor signaling pathway involved in somitogenesis", "Notch receptor signalling pathway involved in somitogenesis", "Notch-receptor signaling pathway involved in somitogenesis", "N signaling pathway involved in formation of mesodermal clusters", "N signalling pathway involved in somitogenesis", "Notch signalling pathway involved in formation of mesodermal clusters", "Notch receptor signaling pathway involved in formation of mesodermal clusters", "Notch signaling pathway involved in formation of mesodermal clusters"], "types": ["T044"], "canonical_name": "Notch signaling pathway involved in somitogenesis", "definition": "Any Notch signaling pathway that is involved in somitogenesis. [GOC:dph, GOC:TermGenie, PMID:21795391]"}
{"concept_id": "C3822131", "aliases": [], "types": ["T043"], "canonical_name": "melanocyte apoptotic process", "definition": "Any apoptotic process in a melanocyte, the main structural component of the epidermis. [GOC:ic, GOC:TermGenie, PMID:20530876]"}
{"concept_id": "C3822132", "aliases": [], "types": ["T043"], "canonical_name": "melanocyte apoptosis"}
{"concept_id": "C3822133", "aliases": [], "types": ["T043"], "canonical_name": "melanophore apoptosis"}
{"concept_id": "C3822134", "aliases": [], "types": ["T043"], "canonical_name": "melanophore apoptotic process"}
{"concept_id": "C3822135", "aliases": ["regulation of protein localisation to spindle pole body"], "types": ["T039"], "canonical_name": "regulation of protein localization to spindle pole body", "definition": "Any process that modulates the frequency, rate or extent of protein localization to spindle pole body. [GOC:TermGenie, PMID:21131906]"}
{"concept_id": "C3822136", "aliases": ["down regulation of protein localization to spindle pole body", "down-regulation of protein localisation to spindle pole body", "negative regulation of protein localisation to spindle pole body", "downregulation of protein localisation to spindle pole body", "down-regulation of protein localization to spindle pole body", "downregulation of protein localization to spindle pole body", "down regulation of protein localisation to spindle pole body"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to spindle pole body", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to spindle pole body. [GOC:TermGenie, PMID:21131906]"}
{"concept_id": "C3822137", "aliases": ["inhibition of protein localization to spindle pole body"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to spindle pole body"}
{"concept_id": "C3822138", "aliases": ["positive regulation of protein localisation to spindle pole body", "upregulation of protein localisation to spindle pole body", "upregulation of protein localization to spindle pole body", "up regulation of protein localization to spindle pole body", "up-regulation of protein localisation to spindle pole body", "up-regulation of protein localization to spindle pole body", "up regulation of protein localisation to spindle pole body"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to spindle pole body", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to spindle pole body. [GOC:TermGenie, PMID:21131906]"}
{"concept_id": "C3822139", "aliases": ["activation of protein localization to spindle pole body"], "types": ["T043"], "canonical_name": "activation of protein localisation to spindle pole body"}
{"concept_id": "C3822140", "aliases": ["regulation of N signaling pathway involved in formation of mesodermal clusters", "regulation of Notch receptor signaling pathway involved in somitogenesis", "regulation of N signalling pathway involved in formation of mesodermal clusters", "regulation of N signaling pathway involved in somitogenesis", "regulation of Notch-receptor signaling pathway involved in somitogenesis", "regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters", "regulation of Notch signaling pathway involved in formation of mesodermal clusters", "regulation of Notch signalling pathway involved in somitogenesis", "regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters", "regulation of Notch-receptor signalling pathway involved in somitogenesis", "regulation of Notch signalling pathway involved in formation of mesodermal clusters", "regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters", "regulation of Notch receptor signalling pathway involved in somitogenesis", "regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters", "regulation of N signalling pathway involved in somitogenesis"], "types": ["T044"], "canonical_name": "regulation of Notch signaling pathway involved in somitogenesis", "definition": "Any process that modulates the frequency, rate or extent of Notch signaling pathway involved in somitogenesis. [GOC:dph, GOC:TermGenie, PMID:21795391]"}
{"concept_id": "C3822141", "aliases": ["down regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters", "inhibition of Notch receptor signalling pathway involved in somitogenesis", "downregulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters", "down regulation of Notch signalling pathway involved in formation of mesodermal clusters", "negative regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters", "down regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters", "down-regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters", "down regulation of Notch signalling pathway involved in somitogenesis", "down-regulation of Notch receptor signalling pathway involved in somitogenesis", "down-regulation of N signaling pathway involved in somitogenesis", "downregulation of Notch-receptor signalling pathway involved in somitogenesis", "inhibition of Notch-receptor signaling pathway involved in somitogenesis", "downregulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters", "down regulation of N signaling pathway involved in somitogenesis", "down regulation of N signalling pathway involved in formation of mesodermal clusters", "inhibition of Notch receptor signaling pathway involved in somitogenesis", "downregulation of Notch receptor signaling pathway involved in formation of mesodermal clusters", "negative regulation of Notch receptor signalling pathway involved in somitogenesis", "negative regulation of N signalling pathway involved in somitogenesis", "negative regulation of Notch receptor signaling pathway involved in somitogenesis", "down-regulation of Notch receptor signaling pathway involved in somitogenesis", "negative regulation of N signalling pathway involved in formation of mesodermal clusters", "downregulation of Notch signaling pathway involved in somitogenesis", "down-regulation of N signalling pathway involved in formation of mesodermal clusters", "down-regulation of Notch signalling pathway involved in formation of mesodermal clusters", "negative regulation of Notch-receptor signaling pathway involved in somitogenesis", "downregulation of N signaling pathway involved in formation of mesodermal clusters", "negative regulation of N signaling pathway involved in formation of mesodermal clusters", "negative regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters", "down-regulation of Notch-receptor signalling pathway involved in somitogenesis", "downregulation of Notch receptor signaling pathway involved in somitogenesis", "downregulation of Notch signaling pathway involved in formation of mesodermal clusters", "downregulation of N signalling pathway involved in formation of mesodermal clusters", "negative regulation of Notch signalling pathway involved in somitogenesis", "down-regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters", "downregulation of Notch-receptor signaling pathway involved in somitogenesis", "down regulation of Notch-receptor signalling pathway involved in somitogenesis", "down-regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters", "negative regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters", "negative regulation of Notch signalling pathway involved in formation of mesodermal clusters", "negative regulation of Notch-receptor signalling pathway involved in somitogenesis", "downregulation of Notch signalling pathway involved in formation of mesodermal clusters", "down-regulation of N signaling pathway involved in formation of mesodermal clusters", "down-regulation of Notch signaling pathway involved in somitogenesis", "negative regulation of N signaling pathway involved in somitogenesis", "negative regulation of Notch signaling pathway involved in formation of mesodermal clusters", "inhibition of Notch-receptor signalling pathway involved in somitogenesis", "down regulation of Notch signaling pathway involved in formation of mesodermal clusters", "down regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters", "down-regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters", "down regulation of N signaling pathway involved in formation of mesodermal clusters", "negative regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters", "downregulation of Notch receptor signalling pathway involved in somitogenesis", "down regulation of Notch receptor signalling pathway involved in somitogenesis", "down-regulation of Notch signaling pathway involved in formation of mesodermal clusters", "downregulation of Notch receptor signalling pathway involved in formation of mesodermal clusters", "down regulation of N signalling pathway involved in somitogenesis", "down regulation of Notch signaling pathway involved in somitogenesis", "down regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters", "down-regulation of N signalling pathway involved in somitogenesis", "down-regulation of Notch signalling pathway involved in somitogenesis", "down regulation of Notch receptor signaling pathway involved in somitogenesis", "downregulation of N signalling pathway involved in somitogenesis", "downregulation of Notch signalling pathway involved in somitogenesis", "down regulation of Notch-receptor signaling pathway involved in somitogenesis", "downregulation of N signaling pathway involved in somitogenesis", "down-regulation of Notch-receptor signaling pathway involved in somitogenesis"], "types": ["T044"], "canonical_name": "negative regulation of Notch signaling pathway involved in somitogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Notch signaling pathway involved in somitogenesis. [GOC:dph, GOC:TermGenie, PMID:21795391]"}
{"concept_id": "C3822142", "aliases": ["inhibition of N signalling pathway involved in formation of mesodermal clusters"], "types": ["T044"], "canonical_name": "inhibition of N signaling pathway involved in formation of mesodermal clusters"}
{"concept_id": "C3822143", "aliases": ["inhibition of N signalling pathway involved in somitogenesis"], "types": ["T044"], "canonical_name": "inhibition of N signaling pathway involved in somitogenesis"}
{"concept_id": "C3822144", "aliases": ["inhibition of Notch receptor signalling pathway involved in formation of mesodermal clusters", "inhibition of Notch-receptor signaling pathway involved in formation of mesodermal clusters", "inhibition of Notch-receptor signalling pathway involved in formation of mesodermal clusters"], "types": ["T044"], "canonical_name": "inhibition of Notch receptor signaling pathway involved in formation of mesodermal clusters"}
{"concept_id": "C3822145", "aliases": ["inhibition of Notch signalling pathway involved in formation of mesodermal clusters"], "types": ["T044"], "canonical_name": "inhibition of Notch signaling pathway involved in formation of mesodermal clusters"}
{"concept_id": "C3822146", "aliases": ["inhibition of Notch signalling pathway involved in somitogenesis"], "types": ["T044"], "canonical_name": "inhibition of Notch signaling pathway involved in somitogenesis"}
{"concept_id": "C3822149", "aliases": ["down-regulation of RNA catabolism", "down regulation of RNA catabolism", "downregulation of RNA degradation", "down-regulation of RNA catabolic process", "inhibition of RNA breakdown", "downregulation of RNA catabolism", "negative regulation of RNA degradation", "down regulation of RNA degradation", "down-regulation of RNA breakdown", "downregulation of RNA catabolic process", "down regulation of RNA catabolic process", "negative regulation of RNA catabolism", "downregulation of RNA breakdown", "negative regulation of RNA breakdown", "down-regulation of RNA degradation", "down regulation of RNA breakdown"], "types": ["T044"], "canonical_name": "negative regulation of RNA catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. [GOC:bf, GOC:TermGenie, PMID:16640457]"}
{"concept_id": "C3822150", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA catabolic process"}
{"concept_id": "C3822151", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA catabolism"}
{"concept_id": "C3822152", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA degradation"}
{"concept_id": "C3822153", "aliases": ["regulation of tRNA breakdown", "regulation of tRNA degradation", "regulation of tRNA catabolism"], "types": ["T044"], "canonical_name": "regulation of tRNA catabolic process", "definition": "Any process that modulates the frequency, rate or extent of tRNA catabolic process. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3822154", "aliases": ["down-regulation of tRNA catabolism", "downregulation of tRNA degradation", "down regulation of tRNA catabolic process", "down regulation of tRNA degradation", "down-regulation of tRNA degradation", "down regulation of tRNA catabolism", "negative regulation of tRNA catabolism", "downregulation of tRNA catabolic process", "down regulation of tRNA breakdown", "down-regulation of tRNA breakdown", "negative regulation of tRNA degradation", "negative regulation of tRNA breakdown", "down-regulation of tRNA catabolic process", "downregulation of tRNA catabolism", "downregulation of tRNA breakdown"], "types": ["T044"], "canonical_name": "negative regulation of tRNA catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA catabolic process. [GOC:bf, GOC:TermGenie, PMID:22919049]"}
{"concept_id": "C3822155", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tRNA breakdown"}
{"concept_id": "C3822156", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tRNA catabolic process"}
{"concept_id": "C3822157", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tRNA catabolism"}
{"concept_id": "C3822158", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tRNA degradation"}
{"concept_id": "C3822159", "aliases": ["up regulation of tRNA catabolic process", "up-regulation of tRNA degradation", "up regulation of tRNA catabolism", "upregulation of tRNA catabolic process", "positive regulation of tRNA breakdown", "upregulation of tRNA breakdown", "up regulation of tRNA degradation", "activation of tRNA degradation", "upregulation of tRNA catabolism", "up regulation of tRNA breakdown", "up-regulation of tRNA catabolic process", "positive regulation of tRNA catabolism", "positive regulation of tRNA degradation", "up-regulation of tRNA breakdown", "up-regulation of tRNA catabolism", "upregulation of tRNA degradation"], "types": ["T044"], "canonical_name": "positive regulation of tRNA catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of tRNA catabolic process. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3822160", "aliases": [], "types": ["T044"], "canonical_name": "activation of tRNA breakdown"}
{"concept_id": "C3822161", "aliases": [], "types": ["T044"], "canonical_name": "activation of tRNA catabolic process"}
{"concept_id": "C3822162", "aliases": [], "types": ["T044"], "canonical_name": "activation of tRNA catabolism"}
{"concept_id": "C3822163", "aliases": ["down regulation of mRNA breakdown", "down-regulation of mRNA catabolism", "negative regulation of mRNA breakdown", "down regulation of mRNA catabolism", "down regulation of mRNA catabolic process", "down regulation of mRNA degradation", "negative regulation of mRNA catabolism", "down-regulation of mRNA breakdown", "downregulation of mRNA catabolic process", "down-regulation of mRNA degradation", "down-regulation of mRNA catabolic process", "downregulation of mRNA breakdown", "downregulation of mRNA degradation", "negative regulation of mRNA decay", "negative regulation of mRNA degradation", "downregulation of mRNA catabolism"], "types": ["T044"], "canonical_name": "negative regulation of mRNA catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process. [GOC:bf, GOC:TermGenie, PMID:22626865]"}
{"concept_id": "C3822164", "aliases": ["down-regulation of mRNA decay"], "types": ["T044"], "canonical_name": "down regulation of mRNA decay"}
{"concept_id": "C3822165", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of mRNA decay"}
{"concept_id": "C3822166", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA breakdown"}
{"concept_id": "C3822167", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA catabolic process"}
{"concept_id": "C3822168", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA catabolism"}
{"concept_id": "C3822169", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA decay"}
{"concept_id": "C3822170", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA degradation"}
{"concept_id": "C3822171", "aliases": ["regulation of rRNA degradation", "regulation of rRNA breakdown", "regulation of rRNA catabolism"], "types": ["T044"], "canonical_name": "regulation of rRNA catabolic process", "definition": "Any process that modulates the frequency, rate or extent of rRNA catabolic process. [GOC:bf, GOC:TermGenie, PMID:20160119]"}
{"concept_id": "C3822172", "aliases": ["endonucleolytic tRNA 3'-end cleavage in nucleus", "tRNA 3'-end cleavage, endonucleolytic in cell nucleus", "endonucleolytic tRNA 3'-end cleavage in cell nucleus", "tRNA 3'-end cleavage, endonucleolytic in nucleus", "tRNA 3'-trailer cleavage, endonucleolytic in cell nucleus", "endonucleolytic tRNA 3'-trailer cleavage in cell nucleus"], "types": ["T045"], "canonical_name": "nuclear tRNA 3'-trailer cleavage, endonucleolytic", "definition": "Any tRNA 3'-trailer cleavage, endonucleolytic that takes place in nucleus. [GOC:TermGenie, PMID:23928301]"}
{"concept_id": "C3822174", "aliases": [], "types": ["T045"], "canonical_name": "endonucleolytic tRNA 3'-trailer cleavage in nucleus"}
{"concept_id": "C3822179", "aliases": ["VEGF-Npn-1 signaling involved in axon guidance", "VEGF-activated neuropilin signaling pathway involved in axon pathfinding", "VEGF-Npn-1 signaling involved in axon chemotaxis"], "types": ["T044"], "canonical_name": "VEGF-activated neuropilin signaling pathway involved in axon guidance", "definition": "Any VEGF-activated neuropilin signaling pathway that is involved in axon guidance. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]"}
{"concept_id": "C3822180", "aliases": [], "types": ["T044"], "canonical_name": "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon chemotaxis"}
{"concept_id": "C3822181", "aliases": [], "types": ["T044"], "canonical_name": "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon growth cone guidance"}
{"concept_id": "C3822182", "aliases": [], "types": ["T044"], "canonical_name": "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon guidance"}
{"concept_id": "C3822183", "aliases": [], "types": ["T044"], "canonical_name": "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon pathfinding"}
{"concept_id": "C3822184", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-activated neuropilin signaling pathway involved in axon chemotaxis"}
{"concept_id": "C3822185", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-activated neuropilin signaling pathway involved in axon growth cone guidance"}
{"concept_id": "C3822186", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-Npn-1 signaling involved in axon growth cone guidance"}
{"concept_id": "C3822187", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-Npn-1 signaling involved in axon pathfinding"}
{"concept_id": "C3822188", "aliases": ["chemoattractant activity involved in axon pathfinding"], "types": ["T044"], "canonical_name": "chemoattractant activity involved in axon guidance", "definition": "Any chemoattractant activity that is involved in axon guidance. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]"}
{"concept_id": "C3822189", "aliases": [], "types": ["T044"], "canonical_name": "chemoattractant activity involved in axon chemotaxis"}
{"concept_id": "C3822190", "aliases": [], "types": ["T044"], "canonical_name": "chemoattractant activity involved in axon growth cone guidance"}
{"concept_id": "C3822191", "aliases": ["up regulation of endoribonuclease activity", "upregulation of endoribonuclease activity", "up-regulation of endoribonuclease activity"], "types": ["T044"], "canonical_name": "positive regulation of endoribonuclease activity", "definition": "Any process that activates or increases the frequency, rate or extent of endoribonuclease activity. [GOC:bf, GOC:TermGenie]"}
{"concept_id": "C3822192", "aliases": [], "types": ["T044"], "canonical_name": "activation of endonuclease G activity"}
{"concept_id": "C3822193", "aliases": [], "types": ["T044"], "canonical_name": "activation of endoribonuclease activity"}
{"concept_id": "C3822194", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of endonuclease G activity"}
{"concept_id": "C3822195", "aliases": ["up-regulation of endonuclease G activity"], "types": ["T044"], "canonical_name": "up regulation of endonuclease G activity"}
{"concept_id": "C3822196", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of endonuclease G activity"}
{"concept_id": "C3822197", "aliases": ["11-oxo-beta-amyrin metabolism"], "types": ["T044"], "canonical_name": "11-oxo-beta-amyrin metabolic process", "definition": "The chemical reactions and pathways involving 11-oxo-beta-amyrin. [GOC:TermGenie, pmid:22128119]"}
{"concept_id": "C3822198", "aliases": ["11-oxo-beta-amyrin degradation", "11-oxo-beta-amyrin catabolism", "11-oxo-beta-amyrin breakdown"], "types": ["T044"], "canonical_name": "11-oxo-beta-amyrin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 11-oxo-beta-amyrin. [GOC:TermGenie, pmid:22128119]"}
{"concept_id": "C3822199", "aliases": ["11-oxo-beta-amyrin biosynthesis", "11-oxo-beta-amyrin anabolism", "11-oxo-beta-amyrin formation", "11-oxo-beta-amyrin synthesis"], "types": ["T044"], "canonical_name": "11-oxo-beta-amyrin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 11-oxo-beta-amyrin. [GOC:TermGenie, pmid:22128119]"}
{"concept_id": "C3822200", "aliases": ["glycyrrhetinate metabolism"], "types": ["T044"], "canonical_name": "glycyrrhetinate metabolic process", "definition": "The chemical reactions and pathways involving glycyrrhetinate. [GOC:TermGenie, pmid:22128119]"}
{"concept_id": "C3822201", "aliases": ["glycyrrhetinate degradation", "glycyrrhetinate breakdown", "glycyrrhetinate catabolism"], "types": ["T044"], "canonical_name": "glycyrrhetinate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glycyrrhetinate. [GOC:TermGenie, pmid:22128119]"}
{"concept_id": "C3822202", "aliases": ["glycyrrhetinate anabolism", "glycyrrhetinate biosynthesis", "glycyrrhetinate synthesis", "glycyrrhetinate formation"], "types": ["T044"], "canonical_name": "glycyrrhetinate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glycyrrhetinate. [GOC:TermGenie, pmid:22128119]"}
{"concept_id": "C3822203", "aliases": [], "types": ["T044"], "canonical_name": "ceramide 1-phosphate binding", "definition": "Binding to ceramide 1-phosphate. [GOC:TermGenie, PMID:23863933]"}
{"concept_id": "C3822204", "aliases": [], "types": ["T044"], "canonical_name": "ceramide 1-phosphate transporter activity"}
{"concept_id": "C3822205", "aliases": [], "types": ["T044"], "canonical_name": "regulation of N-terminal peptidyl-serine acetylation", "definition": "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-serine acetylation. [GOC:TermGenie, PMID:23912279]"}
{"concept_id": "C3822206", "aliases": ["up-regulation of N-terminal peptidyl-serine acetylation", "up regulation of N-terminal peptidyl-serine acetylation", "upregulation of N-terminal peptidyl-serine acetylation"], "types": ["T044"], "canonical_name": "positive regulation of N-terminal peptidyl-serine acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-serine acetylation. [GOC:TermGenie, PMID:23912279]"}
{"concept_id": "C3822207", "aliases": [], "types": ["T044"], "canonical_name": "activation of N-terminal peptidyl-serine acetylation"}
{"concept_id": "C3822208", "aliases": [], "types": ["T044"], "canonical_name": "regulation of exodeoxyribonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of exodeoxyribonuclease activity. [GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3822209", "aliases": ["down regulation of exodeoxyribonuclease activity", "downregulation of exodeoxyribonuclease activity", "down-regulation of exodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of exodeoxyribonuclease activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of exodeoxyribonuclease activity. [GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3822210", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of exodeoxyribonuclease activity"}
{"concept_id": "C3822211", "aliases": ["upregulation of exodeoxyribonuclease activity", "up-regulation of exodeoxyribonuclease activity", "up regulation of exodeoxyribonuclease activity"], "types": ["T044"], "canonical_name": "positive regulation of exodeoxyribonuclease activity", "definition": "Any process that activates or increases the frequency, rate or extent of exodeoxyribonuclease activity. [GOC:jl, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3822212", "aliases": [], "types": ["T044"], "canonical_name": "activation of exodeoxyribonuclease activity"}
{"concept_id": "C3822213", "aliases": ["regulation of 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity", "regulation of DOXP synthase activity", "regulation of DXP-synthase activity", "regulation of 1-deoxyxylulose-5-phosphate synthase activity", "regulation of pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)"], "types": ["T044"], "canonical_name": "regulation of 1-deoxy-D-xylulose-5-phosphate synthase activity", "definition": "Any process that modulates the frequency, rate or extent of 1-deoxy-D-xylulose-5-phosphate synthase activity. [GOC:TermGenie, PMID:23612965]"}
{"concept_id": "C3822214", "aliases": ["protein localisation in tight junction", "protein localization in tight junction", "protein localisation to tight junction"], "types": ["T043"], "canonical_name": "protein localization to bicellular tight junction", "definition": "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction. [GOC:TermGenie, PMID:18332111]"}
{"concept_id": "C3822260", "aliases": ["mitotic actomyosin contractile ring constriction", "cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "mitotic actomyosin contractile ring contraction", "definition": "Any actomyosin contractile ring contraction that is involved in mitotic cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822261", "aliases": ["contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle", "contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "mitotic actomyosin contractile ring localization", "definition": "Any actomyosin contractile ring localization that is involved in mitotic cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822262", "aliases": ["cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle", "contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "mitotic actomyosin contractile ring maintenance", "definition": "Any actomyosin contractile ring maintenance that is involved in mitotic cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822263", "aliases": ["cytokinesis, formation of actomyosin apparatus involved in mitotic cell cycle", "actomyosin apparatus assembly involved in cytokinesis involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "assembly of actomyosin apparatus involved in mitotic cytokinesis", "definition": "Any assembly of mitotic cytokinetic actomyosin apparatus. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822264", "aliases": [], "types": ["T043"], "canonical_name": "formation of actomyosin apparatus involved in cytokinesis involved in mitotic cell cycle"}
{"concept_id": "C3822265", "aliases": ["site selection involved in cell cycle cytokinesis involved in mitotic cell cycle", "site selection involved in cytokinesis involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "mitotic cytokinesis, site selection", "definition": "Any cytokinesis, site selection that is involved in mitotic cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822266", "aliases": ["cell separation following cytokinesis"], "types": ["T043"], "canonical_name": "septum digestion after cytokinesis", "definition": "The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. [GOC:mtg_cell_cycle, GOC:vw]"}
{"concept_id": "C3822271", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cytokinetic process", "definition": "Any cytokinetic process that is involved in mitotic cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822272", "aliases": [], "types": ["T043"], "canonical_name": "septin assembly and septum formation involved in mitotic cell cycle"}
{"concept_id": "C3822273", "aliases": [], "types": ["T043"], "canonical_name": "septin assembly and septum biosynthesis involved in mitotic cell cycle"}
{"concept_id": "C3822274", "aliases": ["regulation of cytokinesis after mitosis"], "types": ["T043"], "canonical_name": "regulation of mitotic cytokinesis", "definition": "Any process that modulates the frequency, rate or extent of mitotic cytokinesis. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822275", "aliases": ["negative regulation of cytokinesis after mitosis", "down regulation of mitotic cytokinesis", "down-regulation of mitotic cytokinesis", "down-regulation of cytokinesis after mitosis", "downregulation of cytokinesis after mitosis", "down regulation of cytokinesis after mitosis", "downregulation of mitotic cytokinesis"], "types": ["T043"], "canonical_name": "negative regulation of mitotic cytokinesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis. [GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3822276", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytokinesis after mitosis"}
{"concept_id": "C3822277", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic cytokinesis"}
{"concept_id": "C3822278", "aliases": ["protein localisation to cell junction", "protein localization in cell junction", "protein localisation in cell junction"], "types": ["T043"], "canonical_name": "protein localization to cell junction", "definition": "A process in which a protein is transported to, or maintained in, a location within a cell junction. [GOC:TermGenie, PMID:18332111]"}
{"concept_id": "C3822279", "aliases": [], "types": ["T044"], "canonical_name": "regulation of mRNA binding", "definition": "Any process that modulates the frequency, rate or extent of mRNA binding. [GOC:rb, GOC:TermGenie, PMID:22890846]"}
{"concept_id": "C3822280", "aliases": ["up-regulation of mRNA binding", "up regulation of mRNA binding", "upregulation of mRNA binding"], "types": ["T044"], "canonical_name": "positive regulation of mRNA binding", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA binding. [GOC:rb, GOC:TermGenie, PMID:22890846]"}
{"concept_id": "C3822281", "aliases": [], "types": ["T044"], "canonical_name": "activation of mRNA binding"}
{"concept_id": "C3822282", "aliases": ["abscisic acid glucosyl ester transmembrane transporter activity", "ABA-GE transmembrane transporter activity"], "types": ["T044"], "canonical_name": "(+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity", "definition": "Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other. [GOC:TermGenie, PMID:24028845]"}
{"concept_id": "C3822283", "aliases": ["abscisic acid glucosyl ester transmembrane transport", "ABA-GE transmembrane transport"], "types": ["T043"], "canonical_name": "(+)-abscisic acid D-glucopyranosyl ester transmembrane transport", "definition": "The process in which (+)-abscisic acid D-glucopyranosyl este is transported across a membrane. [GOC:TermGenie, PMID:24028845]"}
{"concept_id": "C3822292", "aliases": ["dihydrogen metabolism", "molecular hydrogen metabolism", "H2 metabolism"], "types": ["T040"], "canonical_name": "hydrogen metabolic process", "definition": "The chemical reactions and pathways involving H2 (dihydrogen). [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761]"}
{"concept_id": "C3822293", "aliases": ["molecular hydrogen biosynthesis", "hydrogen synthesis", "dihydrogen synthesis", "hydrogen formation", "hydrogen generation", "hydrogen anabolism", "hydrogen biosynthesis", "hydrogen production", "H2 biosynthesis"], "types": ["T038"], "canonical_name": "hydrogen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen). [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761]"}
{"concept_id": "C3822294", "aliases": ["regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation", "regulation of mitotic attachment of spindle microtubules to kinetochore", "regulation of attachment of spindle microtubules to kinetochore involved in mitosis", "regulation of attachment of spindle microtubules to mitotic chromosome"], "types": ["T043"], "canonical_name": "regulation of attachment of mitotic spindle microtubules to kinetochore", "definition": "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. [GOC:TermGenie, GOC:vw, PMID:22065639]"}
{"concept_id": "C3822295", "aliases": [], "types": ["T043"], "canonical_name": "regulation of attachment of spindle microtubules to kinetochore during mitosis"}
{"concept_id": "C3822296", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic bipolar attachment"}
{"concept_id": "C3822297", "aliases": ["down-regulation of attachment of spindle microtubules to kinetochore involved in mitosis", "down regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation", "down regulation of attachment of spindle microtubules to mitotic chromosome", "down regulation of attachment of spindle microtubules to kinetochore involved in mitosis", "negative regulation of attachment of spindle microtubules to kinetochore involved in mitosis", "down-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation", "downregulation of attachment of spindle microtubules to kinetochore involved in mitosis", "downregulation of attachment of spindle microtubules to mitotic chromosome", "negative regulation of attachment of spindle microtubules to mitotic chromosome", "downregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation", "negative regulation of mitotic attachment of spindle microtubules to kinetochore", "down-regulation of attachment of spindle microtubules to mitotic chromosome", "negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation"], "types": ["T043"], "canonical_name": "negative regulation of attachment of mitotic spindle microtubules to kinetochore", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. [GOC:TermGenie, GOC:vw, PMID:22065639]"}
{"concept_id": "C3822298", "aliases": ["down-regulation of attachment of spindle microtubules to kinetochore during mitosis"], "types": ["T043"], "canonical_name": "down regulation of attachment of spindle microtubules to kinetochore during mitosis"}
{"concept_id": "C3822299", "aliases": ["down-regulation of mitotic bipolar attachment"], "types": ["T043"], "canonical_name": "down regulation of mitotic bipolar attachment"}
{"concept_id": "C3822300", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of attachment of spindle microtubules to kinetochore during mitosis"}
{"concept_id": "C3822301", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of mitotic bipolar attachment"}
{"concept_id": "C3822302", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of attachment of spindle microtubules to kinetochore during mitosis"}
{"concept_id": "C3822303", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of attachment of spindle microtubules to kinetochore involved in mitosis"}
{"concept_id": "C3822304", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation"}
{"concept_id": "C3822305", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of attachment of spindle microtubules to mitotic chromosome"}
{"concept_id": "C3822306", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic bipolar attachment"}
{"concept_id": "C3822307", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of attachment of spindle microtubules to kinetochore during mitosis"}
{"concept_id": "C3822308", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic bipolar attachment"}
{"concept_id": "C3822309", "aliases": ["up-regulation of attachment of spindle microtubules to mitotic chromosome", "upregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation", "upregulation of attachment of spindle microtubules to kinetochore involved in mitosis", "up-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation", "up-regulation of attachment of spindle microtubules to kinetochore involved in mitosis", "up regulation of attachment of spindle microtubules to mitotic chromosome", "positive regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation", "upregulation of attachment of spindle microtubules to mitotic chromosome", "up regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation", "positive regulation of attachment of spindle microtubules to kinetochore during mitosis", "positive regulation of attachment of spindle microtubules to mitotic chromosome", "positive regulation of attachment of spindle microtubules to kinetochore involved in mitosis", "up regulation of attachment of spindle microtubules to kinetochore involved in mitosis"], "types": ["T043"], "canonical_name": "positive regulation of attachment of mitotic spindle microtubules to kinetochore", "definition": "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. [GOC:TermGenie, PMID:22065639]"}
{"concept_id": "C3822310", "aliases": [], "types": ["T043"], "canonical_name": "activation of attachment of spindle microtubules to kinetochore during mitosis"}
{"concept_id": "C3822311", "aliases": [], "types": ["T043"], "canonical_name": "activation of attachment of spindle microtubules to kinetochore involved in mitosis"}
{"concept_id": "C3822312", "aliases": [], "types": ["T043"], "canonical_name": "activation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation"}
{"concept_id": "C3822313", "aliases": [], "types": ["T043"], "canonical_name": "activation of attachment of spindle microtubules to mitotic chromosome"}
{"concept_id": "C3822314", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic bipolar attachment"}
{"concept_id": "C3822315", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic bipolar attachment"}
{"concept_id": "C3822316", "aliases": ["up-regulation of attachment of spindle microtubules to kinetochore during mitosis"], "types": ["T043"], "canonical_name": "up regulation of attachment of spindle microtubules to kinetochore during mitosis"}
{"concept_id": "C3822317", "aliases": ["up-regulation of mitotic bipolar attachment"], "types": ["T043"], "canonical_name": "up regulation of mitotic bipolar attachment"}
{"concept_id": "C3822318", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of attachment of spindle microtubules to kinetochore during mitosis"}
{"concept_id": "C3822319", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of mitotic bipolar attachment"}
{"concept_id": "C3822320", "aliases": ["downregulation of mitotic cell cycle spindle assembly checkpoint", "down-regulation of mitotic spindle assembly checkpoint", "down-regulation of Mad2-dependent checkpoint", "down regulation of mitotic cell cycle spindle assembly checkpoint", "negative regulation of mitotic cell cycle spindle assembly checkpoint", "down regulation of Mad2-dependent checkpoint", "downregulation of mitotic spindle assembly checkpoint", "down-regulation of mitotic cell cycle spindle assembly checkpoint", "down regulation of mitotic spindle assembly checkpoint"], "types": ["T043"], "canonical_name": "negative regulation of mitotic spindle assembly checkpoint"}
{"concept_id": "C3822321", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of Mad2-dependent checkpoint"}
{"concept_id": "C3822322", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Mad2-dependent checkpoint"}
{"concept_id": "C3822323", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic cell cycle spindle assembly checkpoint"}
{"concept_id": "C3822324", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic spindle assembly checkpoint"}
{"concept_id": "C3822325", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Mad2-dependent checkpoint"}
{"concept_id": "C3822326", "aliases": [], "types": ["T039"], "canonical_name": "regulation of water channel activity", "definition": "Any process that modulates the frequency, rate or extent of water channel activity. [GOC:nhn, GOC:TermGenie, PMID:22095752]"}
{"concept_id": "C3822327", "aliases": [], "types": ["T039"], "canonical_name": "regulation of aquaporin"}
{"concept_id": "C3822328", "aliases": [], "types": ["T039"], "canonical_name": "regulation of aquaporin permeability"}
{"concept_id": "C3822329", "aliases": ["downregulation of water channel activity", "down-regulation of water channel activity", "down regulation of water channel activity"], "types": ["T039"], "canonical_name": "negative regulation of water channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of water channel activity. [GOC:TermGenie]"}
{"concept_id": "C3822330", "aliases": ["down-regulation of aquaporin"], "types": ["T039"], "canonical_name": "down regulation of aquaporin"}
{"concept_id": "C3822331", "aliases": [], "types": ["T039"], "canonical_name": "downregulation of aquaporin"}
{"concept_id": "C3822332", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of aquaporin"}
{"concept_id": "C3822333", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of water channel activity"}
{"concept_id": "C3822334", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of aquaporin"}
{"concept_id": "C3822335", "aliases": ["up regulation of water channel activity", "up-regulation of water channel activity", "upregulation of water channel activity", "aquaporin activation", "activation of aquaporin"], "types": ["T038"], "canonical_name": "positive regulation of water channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of water channel activity. [GOC:nhn, GOC:TermGenie, PMID:22095752]"}
{"concept_id": "C3822336", "aliases": [], "types": ["T039"], "canonical_name": "activation of water channel activity"}
{"concept_id": "C3822337", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of aquaporin"}
{"concept_id": "C3822338", "aliases": ["up-regulation of aquaporin"], "types": ["T039"], "canonical_name": "up regulation of aquaporin"}
{"concept_id": "C3822339", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of aquaporin"}
{"concept_id": "C3822340", "aliases": ["negative regulation of beta-amyloid formation", "down regulation of beta-amyloid formation", "down-regulation of beta-amyloid formation", "downregulation of beta-amyloid formation"], "types": ["T040"], "canonical_name": "negative regulation of amyloid-beta formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation. [GOC:hjd, GOC:TermGenie, PMID:22992957]"}
{"concept_id": "C3822341", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of beta-amyloid formation"}
{"concept_id": "C3822343", "aliases": ["protein localisation to division septum", "protein localisation in division septum", "protein localization in division septum"], "types": ["T043"], "canonical_name": "protein localization to division septum", "definition": "A process in which a protein is transported to, or maintained in, a location within a division septum. [GOC:TermGenie, PMID:9367977]"}
{"concept_id": "C3822344", "aliases": ["up-regulation of aquaporin involved in preservation of lens transparency", "up regulation of aquaporin involved in maintenance of lens transparency", "up-regulation of aquaporin involved in maintenance of ocular lens transparency", "up regulation of water channel activity involved in maintenance of lens transparency", "up regulation of water channel activity involved in preservation of lens transparency", "positive regulation of water channel activity involved in preservation of lens transparency", "up-regulation of water channel activity involved in preservation of lens transparency", "up regulation of aquaporin involved in preservation of lens transparency", "upregulation of water channel activity involved in maintenance of lens transparency", "positive regulation of aquaporin involved in maintenance of ocular lens transparency", "up-regulation of water channel activity involved in maintenance of ocular lens transparency", "up regulation of aquaporin involved in maintenance of ocular lens transparency", "up-regulation of water channel activity involved in maintenance of lens transparency", "up regulation of water channel activity involved in maintenance of ocular lens transparency", "up-regulation of aquaporin involved in maintenance of lens transparency", "upregulation of water channel activity involved in preservation of lens transparency", "positive regulation of aquaporin involved in maintenance of lens transparency", "upregulation of water channel activity involved in maintenance of ocular lens transparency", "positive regulation of water channel activity involved in maintenance of ocular lens transparency"], "types": ["T043"], "canonical_name": "positive regulation of water channel activity involved in maintenance of lens transparency", "definition": "Any positive regulation of water channel activity that is involved in maintenance of lens transparency. [GOC:nhn, GOC:TermGenie, PMID:22095752]"}
{"concept_id": "C3822345", "aliases": ["aquaporin activation involved in maintenance of lens transparency"], "types": ["T039"], "canonical_name": "activation of aquaporin involved in maintenance of lens transparency"}
{"concept_id": "C3822346", "aliases": ["aquaporin activation involved in maintenance of ocular lens transparency"], "types": ["T039"], "canonical_name": "activation of aquaporin involved in maintenance of ocular lens transparency"}
{"concept_id": "C3822347", "aliases": ["aquaporin activation involved in preservation of lens transparency"], "types": ["T039"], "canonical_name": "activation of aquaporin involved in preservation of lens transparency"}
{"concept_id": "C3822348", "aliases": [], "types": ["T039"], "canonical_name": "activation of water channel activity involved in maintenance of lens transparency"}
{"concept_id": "C3822349", "aliases": [], "types": ["T039"], "canonical_name": "activation of water channel activity involved in maintenance of ocular lens transparency"}
{"concept_id": "C3822350", "aliases": [], "types": ["T039"], "canonical_name": "activation of water channel activity involved in preservation of lens transparency"}
{"concept_id": "C3822351", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of aquaporin involved in preservation of lens transparency"}
{"concept_id": "C3822352", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of aquaporin involved in maintenance of lens transparency"}
{"concept_id": "C3822353", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of aquaporin involved in maintenance of ocular lens transparency"}
{"concept_id": "C3822354", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of aquaporin involved in preservation of lens transparency"}
{"concept_id": "C3822355", "aliases": ["sulphate import into cell", "sulfate import into cell"], "types": ["T043"], "canonical_name": "sulfate import across plasma membrane", "definition": "The directed movement of sulfate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:TermGenie, PMID:14723223]"}
{"concept_id": "C3822356", "aliases": [], "types": ["T038"], "canonical_name": "regulation of male mating behavior", "definition": "Any process that modulates the frequency, rate or extent of male mating behavior. [GOC:TermGenie, PMID:24089208]"}
{"concept_id": "C3822357", "aliases": ["down-regulation of male mating behavior", "down regulation of male mating behavior", "inhibition of male mating behavior", "downregulation of male mating behavior"], "types": ["T038"], "canonical_name": "negative regulation of male mating behavior", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior. [GOC:TermGenie, PMID:24089208]"}
{"concept_id": "C3822358", "aliases": ["up regulation of male mating behavior", "upregulation of male mating behavior", "up-regulation of male mating behavior"], "types": ["T038"], "canonical_name": "positive regulation of male mating behavior", "definition": "Any process that activates or increases the frequency, rate or extent of male mating behavior. [GOC:TermGenie, PMID:24089208]"}
{"concept_id": "C3822359", "aliases": [], "types": ["T038"], "canonical_name": "activation of male mating behavior"}
{"concept_id": "C3822360", "aliases": [], "types": ["T043"], "canonical_name": "response to vanadate(3-)", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus. [GOC:di, GOC:TermGenie, PMID:7489911]"}
{"concept_id": "C3822361", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to vanadate(3-)", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus. [GOC:di, GOC:TermGenie, PMID:7489911]"}
{"concept_id": "C3822362", "aliases": ["protein localisation to mitotic spindle pole body", "protein localization in mitotic spindle pole body", "protein localisation in mitotic spindle pole body"], "types": ["T043"], "canonical_name": "protein localization to mitotic spindle pole body", "definition": "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body. [GOC:TermGenie, PMID:22438582]"}
{"concept_id": "C3822363", "aliases": ["protein localisation in meiotic spindle pole body", "protein localization in meiotic spindle pole body", "protein localisation to meiotic spindle pole body", "protein location to meiotic spindle pole body"], "types": ["T043"], "canonical_name": "protein localization to meiotic spindle pole body", "definition": "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body. [PMID:20833892]"}
{"concept_id": "C3822364", "aliases": [], "types": ["T040"], "canonical_name": "regulation of ripoptosome assembly involved in necroptotic process", "definition": "Any process that modulates the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process. [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097]"}
{"concept_id": "C3822365", "aliases": [], "types": ["T040"], "canonical_name": "regulation of ripoptosome assembly involved in necroptosis"}
{"concept_id": "C3822366", "aliases": ["downregulation of ripoptosome assembly involved in necroptosis", "down regulation of ripoptosome assembly involved in necroptosis", "down-regulation of ripoptosome assembly involved in necroptosis"], "types": ["T043"], "canonical_name": "negative regulation of ripoptosome assembly involved in necroptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process. [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097]"}
{"concept_id": "C3822367", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ripoptosome assembly involved in necroptosis"}
{"concept_id": "C3822368", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ripoptosome assembly involved in necroptosis"}
{"concept_id": "C3822369", "aliases": [], "types": ["T044"], "canonical_name": "riboflavin binding", "definition": "Binding to riboflavin. [GOC:TermGenie, PMID:12083520]"}
{"concept_id": "C3822370", "aliases": ["regulation of transport across mitochondrial membrane involved in programmed necrotic cell death"], "types": ["T043"], "canonical_name": "regulation of mitochondrial membrane permeability involved in programmed necrotic cell death", "definition": "Any regulation of mitochondrial membrane permeability that is involved in programmed necrotic cell death. [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:22493254]"}
{"concept_id": "C3822371", "aliases": [], "types": ["T039"], "canonical_name": "regulation of shade avoidance", "definition": "Any process that modulates the frequency, rate or extent of shade avoidance. [GOC:TermGenie, PMID:23763263]"}
{"concept_id": "C3822372", "aliases": ["down-regulation of shade avoidance", "downregulation of shade avoidance", "down regulation of shade avoidance"], "types": ["T039"], "canonical_name": "negative regulation of shade avoidance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of shade avoidance. [GOC:TermGenie, PMID:23763263]"}
{"concept_id": "C3822373", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of shade avoidance"}
{"concept_id": "C3822374", "aliases": ["upregulation of shade avoidance", "up regulation of shade avoidance", "up-regulation of shade avoidance"], "types": ["T039"], "canonical_name": "positive regulation of shade avoidance", "definition": "Any process that activates or increases the frequency, rate or extent of shade avoidance. [GOC:TermGenie, PMID:23763263]"}
{"concept_id": "C3822375", "aliases": [], "types": ["T039"], "canonical_name": "activation of shade avoidance"}
{"concept_id": "C3822377", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of ATP-dependent DNA helicase activity"}
{"concept_id": "C3822378", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATP-dependent DNA helicase activity"}
{"concept_id": "C3822380", "aliases": [], "types": ["T043"], "canonical_name": "regulation of amphisome-lysosome fusion"}
{"concept_id": "C3822381", "aliases": [], "types": ["T043"], "canonical_name": "regulation of autolysosome formation"}
{"concept_id": "C3822382", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fusion of autophagosome with lysosome"}
{"concept_id": "C3822384", "aliases": ["downregulation of amphisome-lysosome fusion", "down-regulation of amphisome-lysosome fusion"], "types": ["T043"], "canonical_name": "down regulation of amphisome-lysosome fusion"}
{"concept_id": "C3822385", "aliases": ["down-regulation of autolysosome formation", "downregulation of autolysosome formation"], "types": ["T043"], "canonical_name": "down regulation of autolysosome formation"}
{"concept_id": "C3822386", "aliases": ["downregulation of fusion of autophagosome with lysosome", "down-regulation of fusion of autophagosome with lysosome"], "types": ["T043"], "canonical_name": "down regulation of fusion of autophagosome with lysosome"}
{"concept_id": "C3822389", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of amphisome-lysosome fusion"}
{"concept_id": "C3822390", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of autolysosome formation"}
{"concept_id": "C3822391", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of autophagic vacuole fusion"}
{"concept_id": "C3822392", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of amphisome-lysosome fusion"}
{"concept_id": "C3822393", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of autolysosome formation"}
{"concept_id": "C3822394", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of fusion of autophagosome with lysosome"}
{"concept_id": "C3822396", "aliases": [], "types": ["T043"], "canonical_name": "activation of amphisome-lysosome fusion"}
{"concept_id": "C3822397", "aliases": [], "types": ["T043"], "canonical_name": "activation of autolysosome formation"}
{"concept_id": "C3822398", "aliases": [], "types": ["T043"], "canonical_name": "activation of autophagic vacuole fusion"}
{"concept_id": "C3822399", "aliases": [], "types": ["T043"], "canonical_name": "activation of fusion of autophagosome with lysosome"}
{"concept_id": "C3822400", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of amphisome-lysosome fusion"}
{"concept_id": "C3822401", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of autolysosome formation"}
{"concept_id": "C3822402", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of fusion of autophagosome with lysosome"}
{"concept_id": "C3822403", "aliases": ["up-regulation of amphisome-lysosome fusion", "upregulation of amphisome-lysosome fusion"], "types": ["T043"], "canonical_name": "up regulation of amphisome-lysosome fusion"}
{"concept_id": "C3822404", "aliases": ["upregulation of autolysosome formation", "up-regulation of autolysosome formation"], "types": ["T043"], "canonical_name": "up regulation of autolysosome formation"}
{"concept_id": "C3822405", "aliases": ["up-regulation of fusion of autophagosome with lysosome", "upregulation of fusion of autophagosome with lysosome"], "types": ["T043"], "canonical_name": "up regulation of fusion of autophagosome with lysosome"}
{"concept_id": "C3822409", "aliases": ["down regulation of stem cell maintenance", "downregulation of stem cell maintenance", "down-regulation of stem cell maintenance"], "types": ["T039"], "canonical_name": "negative regulation of stem cell population maintenance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance. [GOC:hjd, GOC:TermGenie, PMID:22969033]"}
{"concept_id": "C3822410", "aliases": ["down-regulation of maintenance of pluripotency"], "types": ["T039"], "canonical_name": "down regulation of maintenance of pluripotency"}
{"concept_id": "C3822411", "aliases": ["negative regulation of maintenance of pluripotency"], "types": ["T043"], "canonical_name": "downregulation of maintenance of pluripotency"}
{"concept_id": "C3822412", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of maintenance of pluripotency"}
{"concept_id": "C3822413", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of stem cell maintenance"}
{"concept_id": "C3822414", "aliases": [], "types": ["T039"], "canonical_name": "regulation of stomatal opening", "definition": "Any process that modulates the frequency, rate or extent of stomatal opening. [GOC:TermGenie, PMID:23766366]"}
{"concept_id": "C3822415", "aliases": ["down regulation of stomatal opening", "downregulation of stomatal opening", "down-regulation of stomatal opening"], "types": ["T043"], "canonical_name": "negative regulation of stomatal opening", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of stomatal opening. [GOC:TermGenie, PMID:23766366]"}
{"concept_id": "C3822416", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of stomatal opening"}
{"concept_id": "C3822417", "aliases": ["up regulation of stomatal opening", "up-regulation of stomatal opening", "upregulation of stomatal opening"], "types": ["T043"], "canonical_name": "positive regulation of stomatal opening", "definition": "Any process that activates or increases the frequency, rate or extent of stomatal opening. [GOC:TermGenie, PMID:23766366]"}
{"concept_id": "C3822418", "aliases": [], "types": ["T043"], "canonical_name": "activation of stomatal opening"}
{"concept_id": "C3822419", "aliases": ["positive regulation of maintenance of pluripotency", "up regulation of stem cell maintenance", "upregulation of stem cell maintenance", "activation of maintenance of pluripotency", "up-regulation of stem cell maintenance", "activation of stem cell maintenance"], "types": ["T040"], "canonical_name": "positive regulation of stem cell population maintenance", "definition": "Any process that activates or increases the frequency, rate or extent of stem cell population maintenance. [GOC:hjd, GOC:TermGenie, PMID:22969033]"}
{"concept_id": "C3822420", "aliases": ["up-regulation of maintenance of pluripotency"], "types": ["T039"], "canonical_name": "up regulation of maintenance of pluripotency"}
{"concept_id": "C3822421", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of maintenance of pluripotency"}
{"concept_id": "C3822422", "aliases": ["regulation of MSC proliferation"], "types": ["T043"], "canonical_name": "regulation of mesenchymal stem cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation. [GOC:pm, GOC:TermGenie, PMID:18672106]"}
{"concept_id": "C3822423", "aliases": ["downregulation of MSC proliferation", "inhibition of mesenchymal stem cell proliferation", "down regulation of MSC proliferation", "down-regulation of mesenchymal stem cell proliferation", "downregulation of mesenchymal stem cell proliferation", "negative regulation of MSC proliferation", "down-regulation of MSC proliferation", "down regulation of mesenchymal stem cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of mesenchymal stem cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell proliferation. [GOC:pm, GOC:TermGenie, PMID:18672106]"}
{"concept_id": "C3822424", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of MSC proliferation"}
{"concept_id": "C3822425", "aliases": ["up regulation of MSC proliferation", "up regulation of mesenchymal stem cell proliferation", "up-regulation of mesenchymal stem cell proliferation", "positive regulation of MSC proliferation", "upregulation of mesenchymal stem cell proliferation", "up-regulation of MSC proliferation", "upregulation of MSC proliferation"], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal stem cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell proliferation. [GOC:pm, GOC:TermGenie, PMID:18672106]"}
{"concept_id": "C3822426", "aliases": [], "types": ["T043"], "canonical_name": "activation of mesenchymal stem cell proliferation"}
{"concept_id": "C3822427", "aliases": [], "types": ["T043"], "canonical_name": "activation of MSC proliferation"}
{"concept_id": "C3822428", "aliases": ["protein localisation in cell leading edge", "protein localisation to cell leading edge", "protein localization in cell leading edge"], "types": ["T043"], "canonical_name": "protein localization to cell leading edge", "definition": "A process in which a protein is transported to, or maintained in, a location within a cell leading edge. [GOC:lb, GOC:TermGenie, PMID:21543326]"}
{"concept_id": "C3822429", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H3-K27 trimethylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K27 trimethylation. [GOC:TermGenie, PMID:19270745]"}
{"concept_id": "C3822430", "aliases": ["down regulation of histone H3-K27 trimethylation", "downregulation of histone H3-K27 trimethylation", "down-regulation of histone H3-K27 trimethylation"], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K27 trimethylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation. [GOC:TermGenie, PMID:19270745]"}
{"concept_id": "C3822431", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H3-K27 trimethylation"}
{"concept_id": "C3822432", "aliases": ["upregulation of histone H3-K27 trimethylation", "up regulation of histone H3-K27 trimethylation", "up-regulation of histone H3-K27 trimethylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K27 trimethylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation. [GOC:TermGenie, PMID:19270745]"}
{"concept_id": "C3822433", "aliases": [], "types": ["T044"], "canonical_name": "activation of histone H3-K27 trimethylation"}
{"concept_id": "C3822437", "aliases": ["regulation of septin assembly and septum formation involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle"}
{"concept_id": "C3822440", "aliases": ["down regulation of formation of division septum involved in mitotic cell cycle", "down regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle", "down-regulation of septin assembly and septum formation involved in mitotic cell cycle", "down-regulation of formation of division septum involved in mitotic cell cycle", "negative regulation of septin assembly and septum formation involved in mitotic cell cycle", "down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle", "downregulation of septin assembly and septum formation involved in mitotic cell cycle", "downregulation of division septum formation involved in mitotic cell cycle", "downregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle", "negative regulation of formation of division septum involved in mitotic cell cycle", "down regulation of septin assembly and septum formation involved in mitotic cell cycle", "down regulation of division septum formation involved in mitotic cell cycle", "down-regulation of division septum formation involved in mitotic cell cycle", "inhibition of septin assembly and septum biosynthesis involved in mitotic cell cycle", "inhibition of septin assembly and septum formation involved in mitotic cell cycle", "down regulation of mitotic division septum assembly", "negative regulation of division septum formation involved in mitotic cell cycle", "down-regulation of mitotic division septum assembly", "downregulation of formation of division septum involved in mitotic cell cycle", "negative regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle", "downregulation of mitotic division septum assembly"], "types": ["T043"], "canonical_name": "negative regulation of mitotic division septum assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. [PMID:22786806]"}
{"concept_id": "C3822452", "aliases": ["activation of mitotic division septum assembly", "activation of septin assembly and septum formation involved in mitotic cell cycle", "activation of division septum formation involved in mitotic cell cycle", "activation of formation of division septum involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "activation of septin assembly and septum biosynthesis involved in mitotic cell cycle"}
{"concept_id": "C3822460", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic actomyosin contractile ring localization", "definition": "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring localization. [GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806]"}
{"concept_id": "C3822461", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic cytokinesis, site selection", "definition": "Any process that modulates the frequency, rate or extent of mitotic cytokinesis, site selection. [GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806]"}
{"concept_id": "C3822462", "aliases": ["regulation of protein localisation to synapse"], "types": ["T039"], "canonical_name": "regulation of protein localization to synapse", "definition": "Any process that modulates the frequency, rate or extent of protein localization to synapse. [GOC:kmv, GOC:TermGenie, PMID:22588719]"}
{"concept_id": "C3822463", "aliases": ["up-regulation of protein localisation to synapse", "positive regulation of protein localisation to synapse", "up regulation of protein localisation to synapse", "up regulation of protein localization to synapse", "up-regulation of protein localization to synapse", "upregulation of protein localization to synapse", "upregulation of protein localisation to synapse"], "types": ["T039"], "canonical_name": "positive regulation of protein localization to synapse", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to synapse. [GOC:kmv, GOC:TermGenie, PMID:22588719]"}
{"concept_id": "C3822464", "aliases": ["activation of protein localization to synapse"], "types": ["T039"], "canonical_name": "activation of protein localisation to synapse"}
{"concept_id": "C3822465", "aliases": [], "types": ["T043"], "canonical_name": "L-alpha-amino acid transmembrane transport", "definition": "The directed movement of L-alpha-amino acid across a membrane. [GOC:kmv, GOC:TermGenie, PMID:14668347]"}
{"concept_id": "C3822466", "aliases": [], "types": ["T043"], "canonical_name": "chloride transmembrane transport", "definition": "The process in which chloride is transported across a membrane. [GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3822477", "aliases": ["protein localization in mitotic spindle", "protein localisation to mitotic spindle", "protein localisation in mitotic spindle"], "types": ["T043"], "canonical_name": "protein localization to mitotic spindle", "definition": "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle. [GOC:TermGenie, PMID:23885124]"}
{"concept_id": "C3822478", "aliases": ["gamma-tubulin complex formation"], "types": ["T044"], "canonical_name": "gamma-tubulin complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a gamma-tubulin complex. [GOC:TermGenie, PMID:23885124]"}
{"concept_id": "C3822479", "aliases": ["regulatory T lymphocyte apoptotic process", "regulatory T-cell apoptotic process", "regulatory T-lymphocyte apoptotic process"], "types": ["T043"], "canonical_name": "regulatory T cell apoptotic process", "definition": "Any apoptotic process in a regulatory T cell. [GOC:nhn, GOC:TermGenie, PMID:20471291]"}
{"concept_id": "C3822480", "aliases": ["regulatory T-cell apoptosis"], "types": ["T043"], "canonical_name": "regulatory T cell apoptosis"}
{"concept_id": "C3822481", "aliases": ["regulatory T-lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "regulatory T lymphocyte apoptosis"}
{"concept_id": "C3822482", "aliases": ["cytotoxic T-cell apoptotic process", "cytotoxic T cell apoptotic process", "cytotoxic T-lymphocyte apoptotic process"], "types": ["T043"], "canonical_name": "cytotoxic T lymphocyte apoptotic process"}
{"concept_id": "C3822483", "aliases": ["cytotoxic T-cell apoptosis"], "types": ["T043"], "canonical_name": "cytotoxic T cell apoptosis"}
{"concept_id": "C3822484", "aliases": ["cytotoxic T-lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "cytotoxic T lymphocyte apoptosis"}
{"concept_id": "C3822485", "aliases": [], "types": ["T043"], "canonical_name": "Sertoli cell apoptotic process", "definition": "Any apoptotic process in a Sertoli cell. [GOC:ic, GOC:TermGenie, PMID:17761895]"}
{"concept_id": "C3822486", "aliases": [], "types": ["T043"], "canonical_name": "Sertoli cell apoptosis"}
{"concept_id": "C3822487", "aliases": [], "types": ["T044"], "canonical_name": "L-cysteine binding", "definition": "Binding to L-cysteine. [GOC:bhm, GOC:TermGenie, PMID:12941942]"}
{"concept_id": "C3822488", "aliases": ["protein localisation to growing cell tip", "protein localisation in growing cell tip", "protein localization in growing cell tip"], "types": ["T043"], "canonical_name": "protein localization to growing cell tip", "definition": "A process in which a protein is transported to, or maintained in, a location within a growing cell tip. [GOC:TermGenie, PMID:23041194]"}
{"concept_id": "C3822489", "aliases": ["protein localisation to non-growing cell tip", "protein localisation in non-growing cell tip", "protein localization in non-growing cell tip"], "types": ["T043"], "canonical_name": "protein localization to non-growing cell tip", "definition": "A process in which a protein is transported to, or maintained in, a location within a non-growing cell tip. [GOC:TermGenie, PMID:21652630, PMID:23041194]"}
{"concept_id": "C3822490", "aliases": ["epithelial cell of bile duct apoptotic process"], "types": ["T043"], "canonical_name": "cholangiocyte apoptotic process", "definition": "Any apoptotic process in a cholangiocyte. [GOC:TermGenie, PMID:22961800]"}
{"concept_id": "C3822491", "aliases": [], "types": ["T043"], "canonical_name": "cholangiocyte apoptosis"}
{"concept_id": "C3822492", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell of bile duct apoptosis"}
{"concept_id": "C3822493", "aliases": [], "types": ["T043"], "canonical_name": "hepatoblast apoptotic process", "definition": "Any apoptotic process in a hepatoblast. [GOC:TermGenie, PMID:22412967]"}
{"concept_id": "C3822494", "aliases": [], "types": ["T043"], "canonical_name": "hepatoblast apoptosis"}
{"concept_id": "C3822495", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sperm capacitation", "definition": "Any process that modulates the frequency, rate or extent of sperm capacitation. [GOC:hjd, GOC:TermGenie, PMID:22539676]"}
{"concept_id": "C3822496", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sperm activation"}
{"concept_id": "C3822497", "aliases": ["inhibition of sperm capacitation", "downregulation of sperm activation", "downregulation of sperm capacitation", "down-regulation of sperm capacitation", "down regulation of sperm capacitation"], "types": ["T043"], "canonical_name": "negative regulation of sperm capacitation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation. [GOC:hjd, GOC:TermGenie, PMID:22539676]"}
{"concept_id": "C3822498", "aliases": ["down-regulation of sperm activation"], "types": ["T043"], "canonical_name": "down regulation of sperm activation"}
{"concept_id": "C3822499", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sperm activation"}
{"concept_id": "C3822500", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of sperm activation"}
{"concept_id": "C3822501", "aliases": ["up regulation of sperm capacitation", "up-regulation of sperm activation", "up-regulation of sperm capacitation", "up regulation of sperm activation", "upregulation of sperm capacitation"], "types": ["T043"], "canonical_name": "positive regulation of sperm capacitation", "definition": "Any process that activates or increases the frequency, rate or extent of sperm capacitation. [GOC:hjd, GOC:TermGenie, PMID:22539676]"}
{"concept_id": "C3822502", "aliases": [], "types": ["T043"], "canonical_name": "activation of sperm activation"}
{"concept_id": "C3822503", "aliases": [], "types": ["T043"], "canonical_name": "activation of sperm capacitation"}
{"concept_id": "C3822504", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of sperm activation"}
{"concept_id": "C3822505", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of sperm activation"}
{"concept_id": "C3822506", "aliases": ["acetyltransferase complex location"], "types": ["T026"], "canonical_name": "acetyltransferase complex", "definition": "A protein complex which is capable of acetyltransferase activity. [GOC:bhm, GOC:TermGenie, PMID:8077207]"}
{"concept_id": "C3822507", "aliases": ["transmembrane transporter complex location"], "types": ["T024"], "canonical_name": "transmembrane transporter complex", "definition": "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. [GOC:bhm, GOC:TermGenie, PMID:18024586]"}
{"concept_id": "C3822510", "aliases": [], "types": ["T043"], "canonical_name": "iron-sulfur cluster transport"}
{"concept_id": "C3822511", "aliases": ["regulation of protein self-ubiquitinylation", "regulation of protein auto-ubiquitinylation", "regulation of protein autoubiquitinylation", "regulation of protein auto-ubiquitination", "regulation of protein self-ubiquitination"], "types": ["T044"], "canonical_name": "regulation of protein autoubiquitination", "definition": "Any process that modulates the frequency, rate or extent of protein autoubiquitination. [GOC:rb, GOC:TermGenie, PMID:24069405]"}
{"concept_id": "C3822512", "aliases": ["positive regulation of protein self-ubiquitinylation", "upregulation of protein auto-ubiquitinylation", "positive regulation of protein self-ubiquitination", "upregulation of protein autoubiquitination", "activation of protein auto-ubiquitinylation", "up-regulation of protein autoubiquitination", "up-regulation of protein auto-ubiquitination", "upregulation of protein autoubiquitinylation", "up-regulation of protein self-ubiquitination", "up regulation of protein self-ubiquitination", "up-regulation of protein auto-ubiquitinylation", "upregulation of protein auto-ubiquitination", "up regulation of protein auto-ubiquitinylation", "up-regulation of protein autoubiquitinylation", "positive regulation of protein auto-ubiquitinylation", "upregulation of protein self-ubiquitinylation", "up regulation of protein self-ubiquitinylation", "up regulation of protein autoubiquitinylation", "upregulation of protein self-ubiquitination", "up regulation of protein autoubiquitination", "up regulation of protein auto-ubiquitination", "positive regulation of protein autoubiquitinylation", "up-regulation of protein self-ubiquitinylation", "positive regulation of protein auto-ubiquitination"], "types": ["T044"], "canonical_name": "positive regulation of protein autoubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of protein autoubiquitination. [GOC:rb, GOC:TermGenie, PMID:24069405]"}
{"concept_id": "C3822513", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein auto-ubiquitination"}
{"concept_id": "C3822514", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein autoubiquitination"}
{"concept_id": "C3822515", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein autoubiquitinylation"}
{"concept_id": "C3822516", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein self-ubiquitination"}
{"concept_id": "C3822517", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein self-ubiquitinylation"}
{"concept_id": "C3822518", "aliases": ["vacuolar HOPS complex location", "vacuolar membrane HOPS complex location", "vacuolar membrane HOPS complex"], "types": ["T026"], "canonical_name": "vacuolar HOPS complex", "definition": "Any HOPS complex that is part of a vacuolar membrane. [GOC:TermGenie, PMID:23645161]"}
{"concept_id": "C3822519", "aliases": ["lysosomal membrane HOPS complex location", "lysosomal HOPS complex location", "lysosomal membrane HOPS complex"], "types": ["T026"], "canonical_name": "lysosomal HOPS complex", "definition": "Any HOPS complex that is part of a lysosomal membrane. [GOC:TermGenie, PMID:23645161]"}
{"concept_id": "C3822520", "aliases": ["multivesicular body HOPS complex location", "multivesicular body membrane HOPS complex location", "multivesicular body membrane HOPS complex"], "types": ["T026"], "canonical_name": "multivesicular body HOPS complex", "definition": "Any HOPS complex that is part of a multivesicular body membrane. [GOC:TermGenie, PMID:23645161]"}
{"concept_id": "C3822521", "aliases": ["adenylyltransferase complex location"], "types": ["T026"], "canonical_name": "adenylyltransferase complex", "definition": "A protein complex which is capable of adenylyltransferase activity. [GOC:bhm, GOC:TermGenie, PMID:11713534]"}
{"concept_id": "C3822522", "aliases": ["ThiF-ThiS complex", "ThiF-ThiS complex location"], "types": ["T026"], "canonical_name": "ThiF-ThiS complex"}
{"concept_id": "C3822530", "aliases": ["thiazole synthase complex location"], "types": ["T026"], "canonical_name": "thiazole synthase complex", "definition": "A protein complex which is capable of thiazole synthase activity. [GOC:bhm, GOC:TermGenie, PMID:12650933]"}
{"concept_id": "C3822531", "aliases": ["2-iminoacetate synthase complex location"], "types": ["T026"], "canonical_name": "2-iminoacetate synthase complex", "definition": "A protein complex which is capable of 2-iminoacetate synthase activity. [GOC:bhm, GOC:TermGenie, PMID:12650933]"}
{"concept_id": "C3822532", "aliases": ["ThiH-ThiG complex location"], "types": ["T026"], "canonical_name": "ThiH-ThiG complex"}
{"concept_id": "C3822533", "aliases": ["methionine-importing complex location", "methionine importer complex location", "methionine importing complex", "methionine importing complex location", "methionine importer complex"], "types": ["T024"], "canonical_name": "methionine-importing complex", "definition": "A protein complex which is capable of methionine-importing activity. [GOC:pr, GOC:TermGenie, PMID:23748165]"}
{"concept_id": "C3822534", "aliases": ["regulation of DNA catabolism during apoptosis", "regulation of endonucleolytic DNA catabolic process involved in apoptosis", "regulation of DNA fragmentation involved in apoptotic nuclear change", "regulation of DNA catabolic process during apoptosis"], "types": ["T044"], "canonical_name": "regulation of apoptotic DNA fragmentation", "definition": "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation. [GOC:hjd, GOC:TermGenie, PMID:15572351, PMID:15723341]"}
{"concept_id": "C3822535", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chromatinolysis"}
{"concept_id": "C3822536", "aliases": [], "types": ["T044"], "canonical_name": "regulation of DNA fragmentation"}
{"concept_id": "C3822537", "aliases": ["down-regulation of DNA catabolic process during apoptosis", "down regulation of apoptotic DNA fragmentation", "down regulation of DNA fragmentation involved in apoptotic nuclear change", "downregulation of apoptotic DNA fragmentation", "downregulation of DNA catabolic process during apoptosis", "negative regulation of endonucleolytic DNA catabolic process involved in apoptosis", "downregulation of DNA fragmentation involved in apoptotic nuclear change", "down regulation of endonucleolytic DNA catabolic process involved in apoptosis", "inhibition of DNA catabolism during apoptosis", "negative regulation of DNA catabolism during apoptosis", "downregulation of DNA catabolism during apoptosis", "down regulation of DNA catabolism during apoptosis", "down regulation of DNA catabolic process during apoptosis", "negative regulation of DNA catabolic process during apoptosis", "down-regulation of DNA catabolism during apoptosis", "down-regulation of DNA fragmentation involved in apoptotic nuclear change", "negative regulation of DNA fragmentation involved in apoptotic nuclear change", "down-regulation of endonucleolytic DNA catabolic process involved in apoptosis", "downregulation of endonucleolytic DNA catabolic process involved in apoptosis", "down-regulation of apoptotic DNA fragmentation"], "types": ["T044"], "canonical_name": "negative regulation of apoptotic DNA fragmentation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. [GOC:hjd, GOC:TermGenie, PMID:15572351]"}
{"concept_id": "C3822538", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of apoptotic DNA fragmentation"}
{"concept_id": "C3822539", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA catabolic process during apoptosis"}
{"concept_id": "C3822540", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA fragmentation involved in apoptotic nuclear change"}
{"concept_id": "C3822541", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of endonucleolytic DNA catabolic process involved in apoptosis"}
{"concept_id": "C3822542", "aliases": ["up-regulation of DNA fragmentation involved in apoptotic nuclear change", "positive regulation of DNA catabolism during apoptosis", "up regulation of DNA catabolic process during apoptosis", "up regulation of apoptotic DNA fragmentation", "up-regulation of DNA catabolic process during apoptosis", "upregulation of DNA fragmentation involved in apoptotic nuclear change", "up regulation of DNA fragmentation involved in apoptotic nuclear change", "upregulation of apoptotic DNA fragmentation", "upregulation of DNA catabolic process during apoptosis", "up-regulation of DNA catabolism during apoptosis", "up regulation of endonucleolytic DNA catabolic process involved in apoptosis", "upregulation of endonucleolytic DNA catabolic process involved in apoptosis", "positive regulation of DNA fragmentation involved in apoptotic nuclear change", "positive regulation of endonucleolytic DNA catabolic process involved in apoptosis", "up regulation of DNA catabolism during apoptosis", "positive regulation of DNA catabolic process during apoptosis", "up-regulation of endonucleolytic DNA catabolic process involved in apoptosis", "up-regulation of apoptotic DNA fragmentation", "upregulation of DNA catabolism during apoptosis"], "types": ["T044"], "canonical_name": "positive regulation of apoptotic DNA fragmentation", "definition": "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. [GOC:hjd, GOC:TermGenie, PMID:15572351]"}
{"concept_id": "C3822543", "aliases": [], "types": ["T044"], "canonical_name": "activation of apoptotic DNA fragmentation"}
{"concept_id": "C3822544", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA catabolic process during apoptosis"}
{"concept_id": "C3822545", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA catabolism during apoptosis"}
{"concept_id": "C3822546", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA fragmentation involved in apoptotic nuclear change"}
{"concept_id": "C3822547", "aliases": [], "types": ["T044"], "canonical_name": "activation of endonucleolytic DNA catabolic process involved in apoptosis"}
{"concept_id": "C3822548", "aliases": ["regulation of microtubule-based organelle localization"], "types": ["T043"], "canonical_name": "regulation of organelle transport along microtubule", "definition": "Any process that modulates the frequency, rate or extent of organelle transport along microtubule. [GOC:dph, GOC:TermGenie, PMID:21147087]"}
{"concept_id": "C3822549", "aliases": [], "types": ["T043"], "canonical_name": "regulation of generation of L-type calcium current"}
{"concept_id": "C3822550", "aliases": ["thioredoxin-disulfide reductase complex location"], "types": ["T026"], "canonical_name": "thioredoxin-disulfide reductase complex", "definition": "A protein complex which is capable of thioredoxin-disulfide reductase activity. [GOC:bhm, GOC:TermGenie, PMID:10947986]"}
{"concept_id": "C3822551", "aliases": [], "types": ["T044"], "canonical_name": "sn-glycerol 3-phosphate binding", "definition": "Binding to sn-glycerol 3-phosphate. [GOC:bhm, GOC:TermGenie, PMID:23013274]"}
{"concept_id": "C3822552", "aliases": ["glycerol-3-phosphate-transporting ATPase complex location"], "types": ["T026"], "canonical_name": "glycerol-3-phosphate-transporting ATPase complex", "definition": "A protein complex which is capable of glycerol-3-phosphate-transporting ATPase activity. [GOC:bhm, GOC:TermGenie, PMID:23013274]"}
{"concept_id": "C3822553", "aliases": [], "types": ["T043"], "canonical_name": "response to cyclophosphamide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus. [GOC:dw, GOC:TermGenie, PMID:23648065]"}
{"concept_id": "C3822554", "aliases": [], "types": ["T043"], "canonical_name": "response to docetaxel trihydrate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus. [GOC:dw, GOC:TermGenie, PMID:23648065]"}
{"concept_id": "C3822555", "aliases": [], "types": ["T043"], "canonical_name": "response to docetaxel"}
{"concept_id": "C3822556", "aliases": [], "types": ["T043"], "canonical_name": "response to doxorubicin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus. [GOC:dw, GOC:TermGenie, PMID:23648065]"}
{"concept_id": "C3822557", "aliases": [], "types": ["T043"], "canonical_name": "response to etoposide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus. [GOC:dw, GOC:TermGenie, PMID:23648065]"}
{"concept_id": "C3822558", "aliases": [], "types": ["T043"], "canonical_name": "response to 4'-epidoxorubicin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus. [GOC:dw, GOC:TermGenie, PMID:23648065]"}
{"concept_id": "C3822559", "aliases": [], "types": ["T043"], "canonical_name": "response to epirubicin"}
{"concept_id": "C3822560", "aliases": ["up-regulation of protein K63-linked ubiquitination", "up-regulation of protein K63-linked polyubiquitination", "upregulation of protein K63-linked ubiquitination", "upregulation of protein K63-linked polyubiquitination", "up regulation of protein K63-linked polyubiquitination", "up regulation of protein K63-linked ubiquitination", "positive regulation of protein K63-linked polyubiquitination"], "types": ["T044"], "canonical_name": "positive regulation of protein K63-linked ubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination. [GOC:TermGenie, PMID:21931591]"}
{"concept_id": "C3822561", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein K63-linked polyubiquitination"}
{"concept_id": "C3822562", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein K63-linked ubiquitination"}
{"concept_id": "C3822563", "aliases": ["up regulation of protein K48-linked polyubiquitination", "activation of protein K48-linked ubiquitination", "upregulation of protein K48-linked polyubiquitination", "up-regulation of protein K48-linked ubiquitination", "up regulation of protein K48-linked ubiquitination", "positive regulation of protein K48-linked polyubiquitination", "upregulation of protein K48-linked ubiquitination", "up-regulation of protein K48-linked polyubiquitination"], "types": ["T044"], "canonical_name": "positive regulation of protein K48-linked ubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination. [GOC:TermGenie, PMID:21931591]"}
{"concept_id": "C3822564", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein K48-linked polyubiquitination"}
{"concept_id": "C3822565", "aliases": ["regulation of protein monoubiquitinylation", "regulation of protein monoubiquitylation"], "types": ["T044"], "canonical_name": "regulation of protein monoubiquitination", "definition": "Any process that modulates the frequency, rate or extent of protein monoubiquitination. [GOC:TermGenie, PMID:21931591]"}
{"concept_id": "C3822566", "aliases": ["negative regulation of protein monoubiquitinylation", "down regulation of protein monoubiquitylation", "down regulation of protein monoubiquitinylation", "down regulation of protein monoubiquitination", "downregulation of protein monoubiquitinylation", "down-regulation of protein monoubiquitylation", "negative regulation of protein monoubiquitylation", "down-regulation of protein monoubiquitinylation", "down-regulation of protein monoubiquitination", "inhibition of protein monoubiquitinylation", "downregulation of protein monoubiquitylation", "downregulation of protein monoubiquitination"], "types": ["T044"], "canonical_name": "negative regulation of protein monoubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein monoubiquitination. [GOC:TermGenie, PMID:21931591]"}
{"concept_id": "C3822567", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein monoubiquitination"}
{"concept_id": "C3822568", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein monoubiquitylation"}
{"concept_id": "C3822569", "aliases": ["up-regulation of protein monoubiquitinylation", "up regulation of protein monoubiquitylation", "activation of protein monoubiquitination", "positive regulation of protein monoubiquitinylation", "up-regulation of protein monoubiquitylation", "up regulation of protein monoubiquitination", "upregulation of protein monoubiquitinylation", "upregulation of protein monoubiquitination", "positive regulation of protein monoubiquitylation", "up regulation of protein monoubiquitinylation", "upregulation of protein monoubiquitylation", "up-regulation of protein monoubiquitination"], "types": ["T044"], "canonical_name": "positive regulation of protein monoubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of protein monoubiquitination. [GOC:TermGenie, PMID:21931591]"}
{"concept_id": "C3822570", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein monoubiquitinylation"}
{"concept_id": "C3822571", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein monoubiquitylation"}
{"concept_id": "C3822572", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein linear polyubiquitination", "definition": "Any process that modulates the frequency, rate or extent of protein linear polyubiquitination. [GOC:TermGenie, PMID:21931591]"}
{"concept_id": "C3822573", "aliases": [], "types": ["T044"], "canonical_name": "regulation of M1 linkage"}
{"concept_id": "C3822574", "aliases": ["downregulation of protein linear polyubiquitination", "down-regulation of protein linear polyubiquitination", "down regulation of protein linear polyubiquitination"], "types": ["T044"], "canonical_name": "negative regulation of protein linear polyubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination. [GOC:TermGenie, PMID:21931591]"}
{"concept_id": "C3822575", "aliases": ["down-regulation of M1 linkage"], "types": ["T044"], "canonical_name": "down regulation of M1 linkage"}
{"concept_id": "C3822576", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of M1 linkage"}
{"concept_id": "C3822577", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of M1 linkage"}
{"concept_id": "C3822578", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein linear polyubiquitination"}
{"concept_id": "C3822579", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of M1 linkage"}
{"concept_id": "C3822580", "aliases": ["up regulation of protein linear polyubiquitination", "upregulation of protein linear polyubiquitination", "up-regulation of protein linear polyubiquitination"], "types": ["T044"], "canonical_name": "positive regulation of protein linear polyubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of protein linear polyubiquitination. [GOC:TermGenie, PMID:21931591]"}
{"concept_id": "C3822581", "aliases": [], "types": ["T044"], "canonical_name": "activation of M1 linkage"}
{"concept_id": "C3822582", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein linear polyubiquitination"}
{"concept_id": "C3822583", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of M1 linkage"}
{"concept_id": "C3822584", "aliases": ["up-regulation of M1 linkage"], "types": ["T044"], "canonical_name": "up regulation of M1 linkage"}
{"concept_id": "C3822585", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of M1 linkage"}
{"concept_id": "C3822586", "aliases": [], "types": ["T044"], "canonical_name": "regulation of intracellular signal transduction pathway"}
{"concept_id": "C3822587", "aliases": [], "types": ["T044"], "canonical_name": "regulation of signal transduction via intracellular signaling cascade"}
{"concept_id": "C3822588", "aliases": [], "types": ["T044"], "canonical_name": "regulation of signal transmission via intracellular cascade"}
{"concept_id": "C3822589", "aliases": ["down-regulation of intracellular signal transduction pathway"], "types": ["T044"], "canonical_name": "down regulation of intracellular signal transduction pathway"}
{"concept_id": "C3822590", "aliases": ["down-regulation of intracellular signaling cascade"], "types": ["T044"], "canonical_name": "down regulation of intracellular signaling cascade"}
{"concept_id": "C3822591", "aliases": ["down-regulation of signal transduction via intracellular signaling cascade"], "types": ["T044"], "canonical_name": "down regulation of signal transduction via intracellular signaling cascade"}
{"concept_id": "C3822592", "aliases": ["down-regulation of signal transmission via intracellular cascade"], "types": ["T044"], "canonical_name": "down regulation of signal transmission via intracellular cascade"}
{"concept_id": "C3822593", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of intracellular signal transduction pathway"}
{"concept_id": "C3822594", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of intracellular signaling cascade"}
{"concept_id": "C3822595", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of intracellular signaling pathway"}
{"concept_id": "C3822596", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of signal transduction via intracellular signaling cascade"}
{"concept_id": "C3822597", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of signal transmission via intracellular cascade"}
{"concept_id": "C3822598", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of intracellular signal transduction"}
{"concept_id": "C3822599", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of intracellular signal transduction pathway"}
{"concept_id": "C3822600", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of intracellular signaling cascade"}
{"concept_id": "C3822601", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of intracellular signaling chain"}
{"concept_id": "C3822602", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of intracellular signaling pathway"}
{"concept_id": "C3822603", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of signal transduction via intracellular signaling cascade"}
{"concept_id": "C3822604", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of signal transmission via intracellular cascade"}
{"concept_id": "C3822605", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of intracellular signal transduction pathway"}
{"concept_id": "C3822606", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of intracellular signaling pathway"}
{"concept_id": "C3822607", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of signal transduction via intracellular signaling cascade"}
{"concept_id": "C3822608", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of signal transmission via intracellular cascade"}
{"concept_id": "C3822609", "aliases": ["positive regulation of intracellular signaling chain", "up-regulation of intracellular signaling chain", "upregulation of intracellular signaling chain", "up-regulation of intracellular signal transduction", "up regulation of intracellular signal transduction", "upregulation of intracellular signal transduction", "up regulation of intracellular signaling chain"], "types": ["T044"], "canonical_name": "positive regulation of intracellular signal transduction", "definition": "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]"}
{"concept_id": "C3822610", "aliases": [], "types": ["T044"], "canonical_name": "activation of intracellular signal transduction"}
{"concept_id": "C3822611", "aliases": [], "types": ["T044"], "canonical_name": "activation of intracellular signal transduction pathway"}
{"concept_id": "C3822612", "aliases": [], "types": ["T044"], "canonical_name": "activation of intracellular signaling cascade"}
{"concept_id": "C3822613", "aliases": [], "types": ["T044"], "canonical_name": "activation of intracellular signaling chain"}
{"concept_id": "C3822614", "aliases": [], "types": ["T044"], "canonical_name": "activation of intracellular signaling pathway"}
{"concept_id": "C3822615", "aliases": [], "types": ["T044"], "canonical_name": "activation of signal transduction via intracellular signaling cascade"}
{"concept_id": "C3822616", "aliases": [], "types": ["T044"], "canonical_name": "activation of signal transmission via intracellular cascade"}
{"concept_id": "C3822617", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of intracellular signal transduction pathway"}
{"concept_id": "C3822618", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of intracellular signaling cascade"}
{"concept_id": "C3822619", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of intracellular signaling pathway"}
{"concept_id": "C3822620", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of signal transduction via intracellular signaling cascade"}
{"concept_id": "C3822621", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of signal transmission via intracellular cascade"}
{"concept_id": "C3822622", "aliases": ["up-regulation of intracellular signal transduction pathway"], "types": ["T044"], "canonical_name": "up regulation of intracellular signal transduction pathway"}
{"concept_id": "C3822623", "aliases": ["up-regulation of intracellular signaling cascade"], "types": ["T044"], "canonical_name": "up regulation of intracellular signaling cascade"}
{"concept_id": "C3822624", "aliases": ["up-regulation of intracellular signaling pathway"], "types": ["T044"], "canonical_name": "up regulation of intracellular signaling pathway"}
{"concept_id": "C3822625", "aliases": ["up-regulation of signal transduction via intracellular signaling cascade"], "types": ["T044"], "canonical_name": "up regulation of signal transduction via intracellular signaling cascade"}
{"concept_id": "C3822626", "aliases": ["up-regulation of signal transmission via intracellular cascade"], "types": ["T044"], "canonical_name": "up regulation of signal transmission via intracellular cascade"}
{"concept_id": "C3822627", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of intracellular signal transduction pathway"}
{"concept_id": "C3822628", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of intracellular signaling cascade"}
{"concept_id": "C3822629", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of intracellular signaling pathway"}
{"concept_id": "C3822630", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of signal transduction via intracellular signaling cascade"}
{"concept_id": "C3822631", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of signal transmission via intracellular cascade"}
{"concept_id": "C3822640", "aliases": ["regulation of protein localisation to mitotic spindle pole body"], "types": ["T039"], "canonical_name": "regulation of protein localization to mitotic spindle pole body", "definition": "Any process that modulates the frequency, rate or extent of protein localization to mitotic spindle pole body. [GOC:TermGenie, PMID:22809626]"}
{"concept_id": "C3822641", "aliases": ["downregulation of protein localisation to mitotic spindle pole body", "down-regulation of protein localisation to mitotic spindle pole body", "down-regulation of protein localization to mitotic spindle pole body", "down-regulation of protein localisation in mitotic spindle pole body", "down regulation of protein localization to mitotic spindle pole body", "downregulation of protein localization to mitotic spindle pole body", "down regulation of protein localisation to mitotic spindle pole body", "negative regulation of protein localisation to mitotic spindle pole body"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to mitotic spindle pole body", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to mitotic spindle pole body. [GOC:TermGenie, PMID:22809626]"}
{"concept_id": "C3822642", "aliases": ["inhibition of protein localization to mitotic spindle pole body"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to mitotic spindle pole body"}
{"concept_id": "C3822643", "aliases": ["regulation of DNA glycosylase activity"], "types": ["T044"], "canonical_name": "regulation of DNA N-glycosylase activity", "definition": "Any process that modulates the frequency, rate or extent of DNA N-glycosylase activity. [GOC:rph, GOC:TermGenie, PMID:15518571]"}
{"concept_id": "C3822644", "aliases": [], "types": ["T044"], "canonical_name": "regulation of endonuclease VIII activity"}
{"concept_id": "C3822645", "aliases": ["down regulation of DNA glycosylase activity", "down regulation of DNA N-glycosylase activity", "downregulation of DNA N-glycosylase activity", "negative regulation of DNA glycosylase activity", "down-regulation of DNA N-glycosylase activity", "down-regulation of DNA glycosylase activity", "downregulation of DNA glycosylase activity"], "types": ["T044"], "canonical_name": "negative regulation of DNA N-glycosylase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA N-glycosylase activity. [GOC:rph, GOC:TermGenie, PMID:15518571]"}
{"concept_id": "C3822646", "aliases": ["down-regulation of endonuclease VIII activity"], "types": ["T044"], "canonical_name": "down regulation of endonuclease VIII activity"}
{"concept_id": "C3822647", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of endonuclease VIII activity"}
{"concept_id": "C3822648", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA glycosylase activity"}
{"concept_id": "C3822649", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA N-glycosylase activity"}
{"concept_id": "C3822650", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of endonuclease VIII activity"}
{"concept_id": "C3822651", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of endonuclease VIII activity"}
{"concept_id": "C3822652", "aliases": ["upregulation of DNA glycosylase activity", "up-regulation of DNA N-glycosylase activity", "up regulation of DNA glycosylase activity", "upregulation of DNA N-glycosylase activity", "up regulation of DNA N-glycosylase activity", "up-regulation of DNA glycosylase activity", "positive regulation of DNA glycosylase activity"], "types": ["T044"], "canonical_name": "positive regulation of DNA N-glycosylase activity", "definition": "Any process that activates or increases the frequency, rate or extent of DNA N-glycosylase activity. [GOC:rph, GOC:TermGenie, PMID:15518571]"}
{"concept_id": "C3822653", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA glycosylase activity"}
{"concept_id": "C3822654", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA N-glycosylase activity"}
{"concept_id": "C3822655", "aliases": [], "types": ["T044"], "canonical_name": "activation of endonuclease VIII activity"}
{"concept_id": "C3822656", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of endonuclease VIII activity"}
{"concept_id": "C3822657", "aliases": ["up-regulation of endonuclease VIII activity"], "types": ["T044"], "canonical_name": "up regulation of endonuclease VIII activity"}
{"concept_id": "C3822658", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of endonuclease VIII activity"}
{"concept_id": "C3822659", "aliases": ["regulation of cellular response to vascular endothelial growth factor", "regulation of cellular response to VEGF"], "types": ["T043"], "canonical_name": "regulation of cellular response to vascular endothelial growth factor stimulus", "definition": "Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370]"}
{"concept_id": "C3822660", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to VEGFA"}
{"concept_id": "C3822661", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to VEGFB"}
{"concept_id": "C3822662", "aliases": ["downregulation of cellular response to vascular endothelial growth factor", "down-regulation of cellular response to VEGF", "down-regulation of cellular response to vascular endothelial growth factor stimulus", "down-regulation of cellular response to vascular endothelial growth factor", "down regulation of cellular response to vascular endothelial growth factor", "down regulation of cellular response to vascular endothelial growth factor stimulus", "down regulation of cellular response to VEGF", "downregulation of cellular response to VEGF", "downregulation of cellular response to vascular endothelial growth factor stimulus", "negative regulation of cellular response to vascular endothelial growth factor", "negative regulation of cellular response to VEGF"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to vascular endothelial growth factor stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370]"}
{"concept_id": "C3822663", "aliases": ["down-regulation of cellular response to VEGFA"], "types": ["T043"], "canonical_name": "down regulation of cellular response to VEGFA"}
{"concept_id": "C3822664", "aliases": ["down-regulation of cellular response to VEGFB"], "types": ["T043"], "canonical_name": "down regulation of cellular response to VEGFB"}
{"concept_id": "C3822665", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of cellular response to VEGFA"}
{"concept_id": "C3822666", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of cellular response to VEGFB"}
{"concept_id": "C3822667", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to vascular endothelial growth factor"}
{"concept_id": "C3822668", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to vascular endothelial growth factor stimulus"}
{"concept_id": "C3822669", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to VEGF"}
{"concept_id": "C3822670", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to VEGFA"}
{"concept_id": "C3822671", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to VEGFB"}
{"concept_id": "C3822672", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular response to VEGFA"}
{"concept_id": "C3822673", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular response to VEGFB"}
{"concept_id": "C3822674", "aliases": ["protein localization in Mei2 nuclear dot", "protein localization to Mei2 dot", "protein localisation in Mei2 nuclear dot", "protein localisation to Mei2 nuclear dot"], "types": ["T043"], "canonical_name": "protein localization to Mei2 nuclear dot", "definition": "A process in which a protein is transported to, or maintained in, a location within a Mei2 nuclear dot. [GOC:TermGenie, PMID:23980030]"}
{"concept_id": "C3822675", "aliases": ["lymphoid lineage cell migration into thymus involved in thymic epithelium morphogenesis", "lymphoid lineage restricted progenitor cell migration into thymus involved in thymus epithelium morphogenesis", "lymphoid lineage restricted progenitor cell migration into thymus involved in thymic epithelium morphogenesis"], "types": ["T043"], "canonical_name": "lymphoid lineage cell migration into thymus involved in thymus epithelium morphogenesis", "definition": "Any lymphoid lineage cell migration into thymus that is involved in thymus epithelium morphogenesis. [GOC:cvs, GOC:TermGenie, PMID:22342843]"}
{"concept_id": "C3822676", "aliases": ["regulation of equilase activity", "regulation of caperase activity", "regulation of catalase-peroxidase activity", "regulation of optidase activity", "regulation of catalase reaction", "regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity"], "types": ["T044"], "canonical_name": "regulation of catalase activity", "definition": "Any process that modulates the frequency, rate or extent of catalase activity. [GOC:TermGenie, PMID:24285797]"}
{"concept_id": "C3822677", "aliases": [], "types": ["T044"], "canonical_name": "regulation of bacterial catalase-peroxidase activity"}
{"concept_id": "C3822678", "aliases": [], "types": ["T044"], "canonical_name": "regulation of CAT"}
{"concept_id": "C3822679", "aliases": ["regulation of heme catalase activity"], "types": ["T044"], "canonical_name": "regulation of haem catalase activity"}
{"concept_id": "C3822680", "aliases": [], "types": ["T044"], "canonical_name": "regulation of manganese catalase activity"}
{"concept_id": "C3822681", "aliases": ["negative regulation of caperase activity", "downregulation of optidase activity", "negative regulation of equilase activity", "down regulation of caperase activity", "down-regulation of catalase-peroxidase activity", "negative regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity", "down regulation of catalase reaction", "down-regulation of optidase activity", "down-regulation of catalase activity", "downregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity", "down-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity", "down regulation of optidase activity", "down regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity", "down-regulation of caperase activity", "down-regulation of catalase reaction", "negative regulation of catalase reaction", "down regulation of catalase-peroxidase activity", "down regulation of equilase activity", "negative regulation of catalase-peroxidase activity", "downregulation of catalase reaction", "down regulation of catalase activity", "downregulation of caperase activity", "downregulation of catalase-peroxidase activity", "down-regulation of equilase activity", "negative regulation of optidase activity", "downregulation of equilase activity", "downregulation of catalase activity"], "types": ["T044"], "canonical_name": "negative regulation of catalase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of catalase activity. [GOC:TermGenie, PMID:24285797]"}
{"concept_id": "C3822682", "aliases": ["down-regulation of bacterial catalase-peroxidase activity"], "types": ["T044"], "canonical_name": "down regulation of bacterial catalase-peroxidase activity"}
{"concept_id": "C3822683", "aliases": ["down-regulation of CAT"], "types": ["T044"], "canonical_name": "down regulation of CAT"}
{"concept_id": "C3822684", "aliases": ["down-regulation of haem catalase activity", "down-regulation of heme catalase activity", "down regulation of heme catalase activity"], "types": ["T044"], "canonical_name": "down regulation of haem catalase activity"}
{"concept_id": "C3822685", "aliases": ["down-regulation of manganese catalase activity"], "types": ["T044"], "canonical_name": "down regulation of manganese catalase activity"}
{"concept_id": "C3822686", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of bacterial catalase-peroxidase activity"}
{"concept_id": "C3822687", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of CAT"}
{"concept_id": "C3822688", "aliases": ["downregulation of heme catalase activity"], "types": ["T044"], "canonical_name": "downregulation of haem catalase activity"}
{"concept_id": "C3822689", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of manganese catalase activity"}
{"concept_id": "C3822690", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bacterial catalase-peroxidase activity"}
{"concept_id": "C3822691", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of caperase activity"}
{"concept_id": "C3822692", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CAT"}
{"concept_id": "C3822693", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of catalase activity"}
{"concept_id": "C3822694", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of catalase reaction"}
{"concept_id": "C3822695", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of catalase-peroxidase activity"}
{"concept_id": "C3822696", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of equilase activity"}
{"concept_id": "C3822697", "aliases": ["inhibition of heme catalase activity"], "types": ["T044"], "canonical_name": "inhibition of haem catalase activity"}
{"concept_id": "C3822698", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity"}
{"concept_id": "C3822699", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of manganese catalase activity"}
{"concept_id": "C3822700", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of optidase activity"}
{"concept_id": "C3822701", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of bacterial catalase-peroxidase activity"}
{"concept_id": "C3822702", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of CAT"}
{"concept_id": "C3822703", "aliases": ["negative regulation of heme catalase activity"], "types": ["T044"], "canonical_name": "negative regulation of haem catalase activity"}
{"concept_id": "C3822704", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of manganese catalase activity"}
{"concept_id": "C3822705", "aliases": ["up-regulation of equilase activity", "upregulation of optidase activity", "positive regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity", "upregulation of equilase activity", "up-regulation of caperase activity", "up regulation of catalase activity", "upregulation of catalase-peroxidase activity", "up regulation of equilase activity", "positive regulation of equilase activity", "upregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity", "up-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity", "positive regulation of optidase activity", "up regulation of caperase activity", "upregulation of catalase reaction", "up regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity", "up regulation of optidase activity", "positive regulation of catalase reaction", "upregulation of catalase activity", "up-regulation of catalase activity", "positive regulation of caperase activity", "up regulation of catalase-peroxidase activity", "upregulation of caperase activity", "up-regulation of optidase activity", "up-regulation of catalase reaction", "up regulation of catalase reaction", "positive regulation of catalase-peroxidase activity", "up-regulation of catalase-peroxidase activity"], "types": ["T044"], "canonical_name": "positive regulation of catalase activity", "definition": "Any process that activates or increases the frequency, rate or extent of catalase activity. [GOC:TermGenie, PMID:24285797]"}
{"concept_id": "C3822706", "aliases": [], "types": ["T044"], "canonical_name": "activation of bacterial catalase-peroxidase activity"}
{"concept_id": "C3822707", "aliases": [], "types": ["T044"], "canonical_name": "activation of caperase activity"}
{"concept_id": "C3822708", "aliases": [], "types": ["T044"], "canonical_name": "activation of CAT"}
{"concept_id": "C3822709", "aliases": [], "types": ["T044"], "canonical_name": "activation of catalase activity"}
{"concept_id": "C3822710", "aliases": [], "types": ["T044"], "canonical_name": "activation of catalase reaction"}
{"concept_id": "C3822711", "aliases": [], "types": ["T044"], "canonical_name": "activation of catalase-peroxidase activity"}
{"concept_id": "C3822712", "aliases": [], "types": ["T044"], "canonical_name": "activation of equilase activity"}
{"concept_id": "C3822713", "aliases": ["activation of heme catalase activity"], "types": ["T044"], "canonical_name": "activation of haem catalase activity"}
{"concept_id": "C3822714", "aliases": [], "types": ["T044"], "canonical_name": "activation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity"}
{"concept_id": "C3822715", "aliases": [], "types": ["T044"], "canonical_name": "activation of manganese catalase activity"}
{"concept_id": "C3822716", "aliases": [], "types": ["T044"], "canonical_name": "activation of optidase activity"}
{"concept_id": "C3822717", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of bacterial catalase-peroxidase activity"}
{"concept_id": "C3822718", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of CAT"}
{"concept_id": "C3822719", "aliases": ["positive regulation of heme catalase activity"], "types": ["T044"], "canonical_name": "positive regulation of haem catalase activity"}
{"concept_id": "C3822720", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of manganese catalase activity"}
{"concept_id": "C3822721", "aliases": ["up-regulation of bacterial catalase-peroxidase activity"], "types": ["T044"], "canonical_name": "up regulation of bacterial catalase-peroxidase activity"}
{"concept_id": "C3822722", "aliases": ["up-regulation of CAT"], "types": ["T044"], "canonical_name": "up regulation of CAT"}
{"concept_id": "C3822723", "aliases": ["up-regulation of heme catalase activity", "up regulation of heme catalase activity", "up-regulation of haem catalase activity"], "types": ["T044"], "canonical_name": "up regulation of haem catalase activity"}
{"concept_id": "C3822724", "aliases": ["up-regulation of manganese catalase activity"], "types": ["T044"], "canonical_name": "up regulation of manganese catalase activity"}
{"concept_id": "C3822725", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of bacterial catalase-peroxidase activity"}
{"concept_id": "C3822726", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of CAT"}
{"concept_id": "C3822727", "aliases": ["upregulation of heme catalase activity"], "types": ["T044"], "canonical_name": "upregulation of haem catalase activity"}
{"concept_id": "C3822728", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of manganese catalase activity"}
{"concept_id": "C3822729", "aliases": ["serine/threonine protein kinase complex location"], "types": ["T026"], "canonical_name": "serine/threonine protein kinase complex", "definition": "A protein complex which is capable of protein serine/threonine kinase activity. [GOC:bhm, GOC:TermGenie, PMID:18191223]"}
{"concept_id": "C3822730", "aliases": ["PDR16 complex location dimer"], "types": ["T026"], "canonical_name": "PDR16 complex dimer"}
{"concept_id": "C3822731", "aliases": ["PDR16 complex location homodimer"], "types": ["T026"], "canonical_name": "PDR16 complex homodimer"}
{"concept_id": "C3822732", "aliases": ["endoribonuclease complex location"], "types": ["T026"], "canonical_name": "endoribonuclease complex", "definition": "A protein complex which is capable of endoribonuclease activity. [GOC:bhm, GOC:TermGenie, PMID:18191223]"}
{"concept_id": "C3822733", "aliases": ["Ire1 complex dimer", "Ire1 complex location dimer"], "types": ["T026"], "canonical_name": "Ire1 complex dimer"}
{"concept_id": "C3822734", "aliases": ["Ire1 complex location homodimer", "Ire1 complex homodimer"], "types": ["T026"], "canonical_name": "Ire1 complex homodimer"}
{"concept_id": "C3822735", "aliases": ["Ire1 complex homooligomer", "Ire1 complex location homooligomer"], "types": ["T026"], "canonical_name": "Ire1 complex homooligomer"}
{"concept_id": "C3822736", "aliases": ["phosphatidylinositol transporter complex location"], "types": ["T026"], "canonical_name": "phosphatidylinositol transporter complex", "definition": "A protein complex which is capable of phosphatidylinositol transporter activity. [GOC:bhm, GOC:TermGenie, PMID:9890948]"}
{"concept_id": "C3822737", "aliases": [], "types": ["T044"], "canonical_name": "5'-adenylyl sulfate transmembrane transporter activity", "definition": "Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other. [GOC:TermGenie, PMID:24296033]"}
{"concept_id": "C3822738", "aliases": ["adenosine 5'-phosphosulfate transmembrane transport"], "types": ["T043"], "canonical_name": "5'-adenylyl sulfate transmembrane transport", "definition": "The process in which 5'-adenylyl sulfate is transported across a membrane. [GOC:TermGenie, PMID:24296033]"}
{"concept_id": "C3822739", "aliases": ["3'-phosphoadenosine 5'-phosphosulfate transmembrane transport"], "types": ["T043"], "canonical_name": "3'-phospho-5'-adenylyl sulfate transmembrane transport", "definition": "The process in which 3'-phospho-5'-adenylyl sulfate is transported across a membrane. [GOC:TermGenie, PMID:24296033]"}
{"concept_id": "C3822740", "aliases": ["GMP reductase complex location"], "types": ["T026"], "canonical_name": "GMP reductase complex", "definition": "An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH(4)(+). [GOC:bhm, GOC:TermGenie, PMID:12009299]"}
{"concept_id": "C3822741", "aliases": ["GMPR1 complex location"], "types": ["T026"], "canonical_name": "GMPR1 complex"}
{"concept_id": "C3822742", "aliases": ["GMPR2 complex location"], "types": ["T026"], "canonical_name": "GMPR2 complex"}
{"concept_id": "C3822743", "aliases": ["ORC formation", "origin of replication recognition complex assembly", "ORC assembly", "origin recognition complex formation", "origin of replication recognition complex formation"], "types": ["T044"], "canonical_name": "origin recognition complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an origin recognition complex. [GOC:TermGenie, PMID:11717425]"}
{"concept_id": "C3822744", "aliases": ["H4 histone acetyltransferase complex location"], "types": ["T026"], "canonical_name": "H4 histone acetyltransferase complex", "definition": "A protein complex which is capable of H4 histone acetyltransferase activity. [GOC:bhm, GOC:TermGenie, PMID:23775086]"}
{"concept_id": "C3822745", "aliases": [], "types": ["T026"], "canonical_name": "Hpa3 (homo-)dimer"}
{"concept_id": "C3822746", "aliases": ["Hpa3 complex location"], "types": ["T026"], "canonical_name": "Hpa3 complex"}
{"concept_id": "C3822747", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil activation", "definition": "Any process that modulates the frequency, rate or extent of neutrophil activation. [GOC:TermGenie, PMID:17588661]"}
{"concept_id": "C3822748", "aliases": ["downregulation of neutrophil activation", "down-regulation of neutrophil activation", "down regulation of neutrophil activation"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation. [GOC:TermGenie, PMID:17588661]"}
{"concept_id": "C3822749", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil activation"}
{"concept_id": "C3822750", "aliases": ["up regulation of neutrophil activation", "upregulation of neutrophil activation", "up-regulation of neutrophil activation"], "types": ["T039"], "canonical_name": "positive regulation of neutrophil activation", "definition": "Any process that activates or increases the frequency, rate or extent of neutrophil activation. [GOC:TermGenie, PMID:17588661]"}
{"concept_id": "C3822751", "aliases": [], "types": ["T039"], "canonical_name": "activation of neutrophil activation"}
{"concept_id": "C3822752", "aliases": [], "types": ["T043"], "canonical_name": "regulation of eosinophil activation", "definition": "Any process that modulates the frequency, rate or extent of eosinophil activation. [GOC:TermGenie, PMID:16254138]"}
{"concept_id": "C3822753", "aliases": ["down regulation of eosinophil activation", "down-regulation of eosinophil activation", "downregulation of eosinophil activation"], "types": ["T043"], "canonical_name": "negative regulation of eosinophil activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil activation. [GOC:TermGenie, PMID:16254138]"}
{"concept_id": "C3822754", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of eosinophil activation"}
{"concept_id": "C3822755", "aliases": ["up regulation of eosinophil activation", "upregulation of eosinophil activation", "up-regulation of eosinophil activation"], "types": ["T039"], "canonical_name": "positive regulation of eosinophil activation", "definition": "Any process that activates or increases the frequency, rate or extent of eosinophil activation. [GOC:TermGenie, PMID:16254138]"}
{"concept_id": "C3822756", "aliases": [], "types": ["T039"], "canonical_name": "activation of eosinophil activation"}
{"concept_id": "C3822757", "aliases": ["down regulation of activation of JAK2 kinase activity", "down regulation of activation of JAK2 protein", "downregulation of activation of JAK2 kinase activity", "negative regulation of activation of JAK2 protein", "down-regulation of activation of JAK2 protein", "down-regulation of activation of JAK2 kinase activity"], "types": ["T040"], "canonical_name": "negative regulation of activation of JAK2 kinase activity"}
{"concept_id": "C3822758", "aliases": ["down-regulation of tyrosine phosphorylation of JAK2 protein"], "types": ["T040"], "canonical_name": "down regulation of tyrosine phosphorylation of JAK2 protein"}
{"concept_id": "C3822759", "aliases": [], "types": ["T040"], "canonical_name": "downregulation of tyrosine phosphorylation of JAK2 protein"}
{"concept_id": "C3822760", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of activation of JAK2 kinase activity"}
{"concept_id": "C3822761", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of activation of JAK2 protein"}
{"concept_id": "C3822762", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of tyrosine phosphorylation of JAK2 protein"}
{"concept_id": "C3822763", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of tyrosine phosphorylation of JAK2 protein"}
{"concept_id": "C3822764", "aliases": ["protein localisation in nucleolus", "protein localization in nucleolus", "protein localisation to nucleolus"], "types": ["T043"], "canonical_name": "protein localization to nucleolus", "definition": "A process in which a protein is transported to, or maintained in, a location within a nucleolus. [GOC:TermGenie, PMID:22809626]"}
{"concept_id": "C3822765", "aliases": ["regulation of serine protease activity"], "types": ["T044"], "canonical_name": "regulation of serine-type peptidase activity", "definition": "Any process that modulates the frequency, rate or extent of serine-type peptidase activity. [GOC:krc, GOC:TermGenie, PMID:20179351]"}
{"concept_id": "C3822766", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of serine-type peptidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity. [GOC:krc, GOC:TermGenie, PMID:20179351]"}
{"concept_id": "C3822767", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of serine protease activity"}
{"concept_id": "C3822768", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of serine-type peptidase activity"}
{"concept_id": "C3822769", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of serine-type peptidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of serine-type peptidase activity. [GOC:krc, GOC:TermGenie, PMID:20179351]"}
{"concept_id": "C3822770", "aliases": [], "types": ["T044"], "canonical_name": "activation of serine protease activity"}
{"concept_id": "C3822771", "aliases": [], "types": ["T044"], "canonical_name": "activation of serine-type peptidase activity"}
{"concept_id": "C3822773", "aliases": ["protein localization to cell division site involved in contractile ring assembly", "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring assembly", "protein localisation to cell division site involved in contractile ring assembly"], "types": ["T043"], "canonical_name": "protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly", "definition": "Any protein localization to cell division site that is involved in cytokinesis, actomyosin contractile ring assembly. [GOC:al, GOC:TermGenie, PMID:24127216]"}
{"concept_id": "C3822774", "aliases": ["protein localization to cell division site involved in constriction ring assembly"], "types": ["T043"], "canonical_name": "protein localisation to cell division site involved in constriction ring assembly"}
{"concept_id": "C3822775", "aliases": ["protein localization to cell division site involved in cytokinesis, actomyosin contractile ring formation"], "types": ["T043"], "canonical_name": "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring formation"}
{"concept_id": "C3822776", "aliases": ["protein localization to cell division site involved in cytokinesis, actomyosin ring biosynthesis"], "types": ["T043"], "canonical_name": "protein localisation to cell division site involved in cytokinesis, actomyosin ring biosynthesis"}
{"concept_id": "C3822777", "aliases": ["protein localization to cell division site involved in cytokinesis, actomyosin ring formation"], "types": ["T043"], "canonical_name": "protein localisation to cell division site involved in cytokinesis, actomyosin ring formation"}
{"concept_id": "C3822778", "aliases": ["protein localization to cell division site involved in cytokinesis, contractile ring assembly"], "types": ["T043"], "canonical_name": "protein localisation to cell division site involved in cytokinesis, contractile ring assembly"}
{"concept_id": "C3822779", "aliases": ["down-regulation of nuclear cell cycle DNA replication", "down-regulation of DNA replication involved in S phase", "down regulation of nuclear cell cycle DNA replication", "down regulation of DNA replication involved in S phase", "down-regulation of DNA replication involved in S-phase", "negative regulation of DNA replication involved in S phase", "downregulation of DNA replication involved in S phase", "negative regulation of DNA replication involved in S-phase", "downregulation of nuclear cell cycle DNA replication", "down regulation of DNA replication involved in S-phase", "downregulation of DNA replication involved in S-phase"], "types": ["T043"], "canonical_name": "negative regulation of nuclear cell cycle DNA replication", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear cell cycle DNA replication. [GOC:TermGenie, PMID:19033384]"}
{"concept_id": "C3822780", "aliases": ["down-regulation of DNA replication during S phase"], "types": ["T043"], "canonical_name": "down regulation of DNA replication during S phase"}
{"concept_id": "C3822781", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of DNA replication during S phase"}
{"concept_id": "C3822782", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of DNA replication during S phase"}
{"concept_id": "C3822783", "aliases": ["inhibition of DNA replication involved in S-phase"], "types": ["T043"], "canonical_name": "inhibition of DNA replication involved in S phase"}
{"concept_id": "C3822784", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nuclear cell cycle DNA replication"}
{"concept_id": "C3822785", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of DNA replication during S phase"}
{"concept_id": "C3822786", "aliases": ["protein localization in medial cortical node", "protein localisation to medial cortical node", "protein localisation in medial cortical node"], "types": ["T043"], "canonical_name": "protein localization to medial cortical node", "definition": "A process in which a protein is transported to, or maintained in, a location within a medial cortical node. [GOC:TermGenie, PMID:24127216]"}
{"concept_id": "C3822791", "aliases": ["single-organism intracellular transport"], "types": ["T043"], "canonical_name": "single organism intracellular transport"}
{"concept_id": "C3822793", "aliases": ["upregulation of response to dehydration", "positive regulation of response to drought", "up-regulation of response to dehydration", "positive regulation of response to thirst", "positive regulation of response to dehydration", "upregulation of response to water deprivation", "upregulation of response to drought", "up-regulation of response to thirst", "up-regulation of response to water deprivation", "upregulation of response to thirst", "up regulation of response to thirst", "up regulation of response to water deprivation", "up regulation of response to dehydration", "up-regulation of response to drought", "up regulation of response to drought"], "types": ["T039"], "canonical_name": "positive regulation of response to water deprivation", "definition": "Any process that activates or increases the frequency, rate or extent of response to water deprivation. [GO_REF:0000058, GOC:TermGenie, PMID:24198318]"}
{"concept_id": "C3822794", "aliases": [], "types": ["T039"], "canonical_name": "activation of drought tolerance"}
{"concept_id": "C3822795", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to dehydration"}
{"concept_id": "C3822796", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to drought"}
{"concept_id": "C3822797", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to thirst"}
{"concept_id": "C3822798", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to water deprivation"}
{"concept_id": "C3822799", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of drought tolerance"}
{"concept_id": "C3822800", "aliases": ["up-regulation of drought tolerance"], "types": ["T039"], "canonical_name": "up regulation of drought tolerance"}
{"concept_id": "C3822801", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of drought tolerance"}
{"concept_id": "C3822802", "aliases": ["single-organism intercellular transport"], "types": ["T043"], "canonical_name": "single organism intercellular transport"}
{"concept_id": "C3822810", "aliases": ["single organism nuclear import"], "types": ["T043"], "canonical_name": "single-organism nuclear import"}
{"concept_id": "C3822812", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ARS binding"}
{"concept_id": "C3822813", "aliases": ["down regulation of DNA replication origin binding", "down-regulation of DNA replication origin binding", "downregulation of DNA replication origin binding"], "types": ["T045"], "canonical_name": "negative regulation of DNA replication origin binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding. [GO_REF:0000059, GOC:TermGenie, PMID:11850415]"}
{"concept_id": "C3822814", "aliases": ["down-regulation of ARS binding"], "types": ["T045"], "canonical_name": "down regulation of ARS binding"}
{"concept_id": "C3822815", "aliases": [], "types": ["T045"], "canonical_name": "downregulation of ARS binding"}
{"concept_id": "C3822816", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of ARS binding"}
{"concept_id": "C3822817", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA replication origin binding"}
{"concept_id": "C3822818", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of ARS binding"}
{"concept_id": "C3822819", "aliases": ["up regulation of DNA replication origin binding", "up-regulation of DNA replication origin binding", "upregulation of DNA replication origin binding"], "types": ["T044"], "canonical_name": "positive regulation of DNA replication origin binding", "definition": "Any process that activates or increases the frequency, rate or extent of DNA replication origin binding. [GO_REF:0000059, GOC:TermGenie, PMID:11850415]"}
{"concept_id": "C3822820", "aliases": [], "types": ["T044"], "canonical_name": "activation of ARS binding"}
{"concept_id": "C3822821", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA replication origin binding"}
{"concept_id": "C3822822", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ARS binding"}
{"concept_id": "C3822823", "aliases": ["up-regulation of ARS binding"], "types": ["T044"], "canonical_name": "up regulation of ARS binding"}
{"concept_id": "C3822824", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of ARS binding"}
{"concept_id": "C3822826", "aliases": [], "types": ["T044"], "canonical_name": "sulfathiazole transmembrane transport", "definition": "The directed movement of sulfathiazole across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3822827", "aliases": ["hydrogen ion transmembrane transport", "hydrogen transmembrane transport"], "types": ["T043"], "canonical_name": "proton transmembrane transport", "definition": "The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3822829", "aliases": [], "types": ["T043"], "canonical_name": "silver ion transmembrane transport", "definition": "The directed movement of silver ion across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3822830", "aliases": [], "types": ["T043"], "canonical_name": "silver transmembrane transport"}
{"concept_id": "C3822831", "aliases": ["aluminium ion transmembrane transport"], "types": ["T043"], "canonical_name": "aluminum ion transmembrane transport", "definition": "The process in which an aluminium ion is transported across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3822832", "aliases": ["aluminum transmembrane transport"], "types": ["T043"], "canonical_name": "aluminium transmembrane transport"}
{"concept_id": "C3822833", "aliases": [], "types": ["T043"], "canonical_name": "carnitine transmembrane transport", "definition": "The directed movement of carnitine across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3822834", "aliases": ["N-(4-aminobenzoyl)-L-glutamate transmembrane transport"], "types": ["T043"], "canonical_name": "p-aminobenzoyl-glutamate transmembrane transport", "definition": "The directed movement of N-(4-aminobenzoyl)-L-glutamate across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3822835", "aliases": ["heterotrimeric G-protein complex formation"], "types": ["T044"], "canonical_name": "heterotrimeric G-protein complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex. [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:23637185]"}
{"concept_id": "C3822836", "aliases": [], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase activity assembly"}
{"concept_id": "C3822837", "aliases": [], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase activity formation"}
{"concept_id": "C3822838", "aliases": [], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase, alpha-subunit assembly"}
{"concept_id": "C3822839", "aliases": [], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase, alpha-subunit formation"}
{"concept_id": "C3822840", "aliases": [], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase, beta-subunit assembly"}
{"concept_id": "C3822841", "aliases": [], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase, beta-subunit formation"}
{"concept_id": "C3822842", "aliases": [], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase, gamma-subunit assembly"}
{"concept_id": "C3822843", "aliases": [], "types": ["T044"], "canonical_name": "heterotrimeric G-protein GTPase, gamma-subunit formation"}
{"concept_id": "C3822844", "aliases": ["regulation of BK calcium-activated potassium channel activity", "regulation of large conductance KCa channels", "regulation of BK KCa channels"], "types": ["T038"], "canonical_name": "regulation of large conductance calcium-activated potassium channel activity", "definition": "Any process that modulates the frequency, rate or extent of large conductance calcium-activated potassium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:23407708]"}
{"concept_id": "C3822845", "aliases": [], "types": ["T038"], "canonical_name": "regulation of BK channel activity"}
{"concept_id": "C3822846", "aliases": ["down-regulation of large conductance calcium-activated potassium channel activity", "negative regulation of BK KCa channels", "down-regulation of BK calcium-activated potassium channel activity", "down regulation of BK KCa channels", "down regulation of large conductance KCa channels", "down regulation of large conductance calcium-activated potassium channel activity", "downregulation of large conductance calcium-activated potassium channel activity", "down-regulation of BK KCa channels", "down regulation of BK calcium-activated potassium channel activity", "negative regulation of large conductance KCa channels", "downregulation of BK KCa channels", "downregulation of BK calcium-activated potassium channel activity", "down-regulation of large conductance KCa channels", "negative regulation of BK calcium-activated potassium channel activity", "downregulation of large conductance KCa channels"], "types": ["T044"], "canonical_name": "negative regulation of large conductance calcium-activated potassium channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of large conductance calcium-activated potassium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:23407708]"}
{"concept_id": "C3822847", "aliases": ["down-regulation of BK channel activity"], "types": ["T044"], "canonical_name": "down regulation of BK channel activity"}
{"concept_id": "C3822848", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of BK channel activity"}
{"concept_id": "C3822849", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of BK calcium-activated potassium channel activity"}
{"concept_id": "C3822850", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of BK channel activity"}
{"concept_id": "C3822851", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of BK KCa channels"}
{"concept_id": "C3822852", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of large conductance calcium-activated potassium channel activity"}
{"concept_id": "C3822853", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of large conductance KCa channels"}
{"concept_id": "C3822854", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of BK channel activity"}
{"concept_id": "C3822855", "aliases": ["up regulation of large conductance KCa channels", "up regulation of large conductance calcium-activated potassium channel activity", "up-regulation of large conductance KCa channels", "upregulation of large conductance calcium-activated potassium channel activity", "upregulation of BK KCa channels", "up regulation of BK KCa channels", "up-regulation of BK KCa channels", "positive regulation of BK KCa channels", "positive regulation of large conductance KCa channels", "upregulation of large conductance KCa channels", "upregulation of BK calcium-activated potassium channel activity", "positive regulation of BK calcium-activated potassium channel activity", "up-regulation of BK calcium-activated potassium channel activity", "up regulation of BK calcium-activated potassium channel activity", "up-regulation of large conductance calcium-activated potassium channel activity"], "types": ["T038"], "canonical_name": "positive regulation of large conductance calcium-activated potassium channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of large conductance calcium-activated potassium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:23407708]"}
{"concept_id": "C3822856", "aliases": [], "types": ["T038"], "canonical_name": "activation of BK calcium-activated potassium channel activity"}
{"concept_id": "C3822857", "aliases": [], "types": ["T038"], "canonical_name": "activation of BK channel activity"}
{"concept_id": "C3822858", "aliases": [], "types": ["T038"], "canonical_name": "activation of BK KCa channels"}
{"concept_id": "C3822859", "aliases": [], "types": ["T038"], "canonical_name": "activation of large conductance calcium-activated potassium channel activity"}
{"concept_id": "C3822860", "aliases": [], "types": ["T038"], "canonical_name": "activation of large conductance KCa channels"}
{"concept_id": "C3822861", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of BK channel activity"}
{"concept_id": "C3822862", "aliases": ["up-regulation of BK channel activity"], "types": ["T038"], "canonical_name": "up regulation of BK channel activity"}
{"concept_id": "C3822863", "aliases": [], "types": ["T038"], "canonical_name": "upregulation of BK channel activity"}
{"concept_id": "C3822864", "aliases": ["(R)-2-hydroxy-alpha-linolenic acid formation", "(R)-2-hydroxy-alpha-linolenic acid biosynthesis", "(R)-2-hydroxy-alpha-linolenic acid anabolism", "(R)-2-hydroxy-alpha-linolenic acid synthesis"], "types": ["T044"], "canonical_name": "(R)-2-hydroxy-alpha-linolenic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (R)-2-hydroxy-alpha-linolenic acid. [GO_REF:0000068, GOC:TermGenie, PMID:24214535]"}
{"concept_id": "C3822865", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-octadecatrienoic acid biosynthesis"}
{"concept_id": "C3822866", "aliases": [], "types": ["T043"], "canonical_name": "response to N-phenylthiourea", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus. [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265]"}
{"concept_id": "C3822867", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to N-phenylthiourea", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus. [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265]"}
{"concept_id": "C3822868", "aliases": [], "types": ["T044"], "canonical_name": "regulation of anti-Mullerian hormone signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of anti-Mullerian hormone signaling pathway. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077]"}
{"concept_id": "C3822869", "aliases": ["down-regulation of anti-Mullerian hormone signaling pathway", "down regulation of anti-Mullerian hormone signaling pathway", "downregulation of anti-Mullerian hormone signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of anti-Mullerian hormone signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077]"}
{"concept_id": "C3822870", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of anti-Mullerian hormone signaling pathway"}
{"concept_id": "C3822871", "aliases": ["up-regulation of anti-Mullerian hormone signaling pathway", "upregulation of anti-Mullerian hormone signaling pathway", "up regulation of anti-Mullerian hormone signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of anti-Mullerian hormone signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of anti-Mullerian hormone signaling pathway. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077]"}
{"concept_id": "C3822872", "aliases": [], "types": ["T044"], "canonical_name": "activation of anti-Mullerian hormone signaling pathway"}
{"concept_id": "C3822873", "aliases": ["immune response involved in response to exogenous double-stranded RNA"], "types": ["T042"], "canonical_name": "immune response involved in response to exogenous dsRNA", "definition": "Any immune response that is involved in response to exogenous dsRNA. [GO_REF:0000060, GOC:pg, GOC:TermGenie, PMID:21266579]"}
{"concept_id": "C3822874", "aliases": [], "types": ["T042"], "canonical_name": "immune response involved in response to viral dsRNA"}
{"concept_id": "C3822875", "aliases": ["O-acylcarnitine transmembrane transport"], "types": ["T043"], "canonical_name": "acyl carnitine transmembrane transport", "definition": "The process in which acyl carnitine is transported across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C3822876", "aliases": [], "types": ["T040"], "canonical_name": "response to fluoride", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus. [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152]"}
{"concept_id": "C3822877", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to fluoride", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus. [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152]"}
{"concept_id": "C3822878", "aliases": [], "types": ["T044"], "canonical_name": "regulation of microtubule minus-end binding", "definition": "Any process that modulates the frequency, rate or extent of microtubule minus-end binding. [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623]"}
{"concept_id": "C3822879", "aliases": ["up-regulation of microtubule minus-end binding", "upregulation of microtubule minus-end binding", "up regulation of microtubule minus-end binding"], "types": ["T044"], "canonical_name": "positive regulation of microtubule minus-end binding", "definition": "Any process that activates or increases the frequency, rate or extent of microtubule minus-end binding. [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623]"}
{"concept_id": "C3822880", "aliases": [], "types": ["T044"], "canonical_name": "activation of microtubule minus-end binding"}
{"concept_id": "C3822881", "aliases": ["CAR disassembly", "contractile actomyosin ring disassembly"], "types": ["T043"], "canonical_name": "actomyosin contractile ring disassembly", "definition": "The disaggregation of an actomyosin contractile ring into its constituent components. [GO_REF:0000079, GOC:TermGenie, PMID:14602073, PMID:22891673]"}
{"concept_id": "C3822882", "aliases": [], "types": ["T043"], "canonical_name": "actomyosin ring disassembly"}
{"concept_id": "C3822883", "aliases": [], "types": ["T043"], "canonical_name": "constriction ring disassembly"}
{"concept_id": "C3822884", "aliases": [], "types": ["T043"], "canonical_name": "cytokinetic ring disassembly"}
{"concept_id": "C3822885", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neutrophil migration", "definition": "Any process that modulates the frequency, rate or extent of neutrophil migration. [GO_REF:0000058, GOC:TermGenie, PMID:1826836]"}
{"concept_id": "C3822886", "aliases": ["down regulation of neutrophil migration", "down-regulation of neutrophil migration", "downregulation of neutrophil migration"], "types": ["T043"], "canonical_name": "negative regulation of neutrophil migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration. [GO_REF:0000058, GOC:TermGenie, PMID:1826836]"}
{"concept_id": "C3822887", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neutrophil migration"}
{"concept_id": "C3822888", "aliases": ["up-regulation of neutrophil migration", "upregulation of neutrophil migration", "up regulation of neutrophil migration"], "types": ["T043"], "canonical_name": "positive regulation of neutrophil migration", "definition": "Any process that activates or increases the frequency, rate or extent of neutrophil migration. [GO_REF:0000058, GOC:TermGenie, PMID:1826836]"}
{"concept_id": "C3822889", "aliases": [], "types": ["T043"], "canonical_name": "activation of neutrophil migration"}
{"concept_id": "C3822891", "aliases": ["preribosome, large subunit precursor formation"], "types": ["T045"], "canonical_name": "assembly of large subunit precursor of preribosome", "definition": "The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome. [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:22735702]"}
{"concept_id": "C3822892", "aliases": [], "types": ["T045"], "canonical_name": "66S preribosome assembly"}
{"concept_id": "C3822893", "aliases": [], "types": ["T045"], "canonical_name": "66S preribosome formation"}
{"concept_id": "C3822894", "aliases": ["regulation of preribosome, large subunit precursor formation"], "types": ["T043"], "canonical_name": "regulation of assembly of large subunit precursor of preribosome", "definition": "Any process that modulates the frequency, rate or extent of assembly of a large subunit precursor of preribosome. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702]"}
{"concept_id": "C3822895", "aliases": [], "types": ["T043"], "canonical_name": "regulation of 66S preribosome assembly"}
{"concept_id": "C3822896", "aliases": [], "types": ["T043"], "canonical_name": "regulation of 66S preribosome formation"}
{"concept_id": "C3822897", "aliases": ["up regulation of preribosome, large subunit precursor formation", "up-regulation of assembly of large subunit precursor of preribosome", "upregulation of assembly of large subunit precursor of preribosome", "upregulation of preribosome, large subunit precursor formation", "up regulation of assembly of large subunit precursor of preribosome", "up-regulation of preribosome, large subunit precursor formation", "positive regulation of preribosome, large subunit precursor formation"], "types": ["T043"], "canonical_name": "positive regulation of assembly of large subunit precursor of preribosome", "definition": "Any process that activates or increases the frequency, rate or extent of assembly of a large subunit precursor of preribosome. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702]"}
{"concept_id": "C3822898", "aliases": [], "types": ["T043"], "canonical_name": "activation of 66S preribosome assembly"}
{"concept_id": "C3822899", "aliases": [], "types": ["T043"], "canonical_name": "activation of 66S preribosome formation"}
{"concept_id": "C3822900", "aliases": [], "types": ["T043"], "canonical_name": "activation of assembly of large subunit precursor of preribosome"}
{"concept_id": "C3822901", "aliases": [], "types": ["T043"], "canonical_name": "activation of preribosome, large subunit precursor formation"}
{"concept_id": "C3822902", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of 66S preribosome assembly"}
{"concept_id": "C3822903", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of 66S preribosome formation"}
{"concept_id": "C3822904", "aliases": ["up-regulation of 66S preribosome assembly"], "types": ["T043"], "canonical_name": "up regulation of 66S preribosome assembly"}
{"concept_id": "C3822905", "aliases": ["up-regulation of 66S preribosome formation"], "types": ["T043"], "canonical_name": "up regulation of 66S preribosome formation"}
{"concept_id": "C3822906", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of 66S preribosome assembly"}
{"concept_id": "C3822907", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of 66S preribosome formation"}
{"concept_id": "C3822908", "aliases": ["regulation of mRNA stability involved in cellular response to UV light stimulus", "regulation of mRNA stability involved in cellular response to ultraviolet radiation stimulus", "regulation of mRNA stability involved in cellular response to UV radiation stimulus", "regulation of mRNA stability involved in cellular response to ultraviolet light stimulus"], "types": ["T045"], "canonical_name": "regulation of mRNA stability involved in cellular response to UV", "definition": "Any regulation of mRNA stability that is involved in cellular response to UV. [GO_REF:0000060, GOC:TermGenie, PMID:10954610]"}
{"concept_id": "C3822909", "aliases": [], "types": ["T038"], "canonical_name": "regulation of membrane hyperpolarization", "definition": "Any process that modulates the frequency, rate or extent of membrane hyperpolarization. [GO_REF:0000058, GOC:TermGenie, PMID:23223304]"}
{"concept_id": "C3822910", "aliases": ["down-regulation of membrane hyperpolarization", "down regulation of membrane hyperpolarization", "downregulation of membrane hyperpolarization"], "types": ["T039"], "canonical_name": "negative regulation of membrane hyperpolarization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane hyperpolarization. [GO_REF:0000058, GOC:TermGenie, PMID:23223304]"}
{"concept_id": "C3822911", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of membrane hyperpolarization"}
{"concept_id": "C3822912", "aliases": ["up-regulation of membrane hyperpolarization", "upregulation of membrane hyperpolarization", "up regulation of membrane hyperpolarization"], "types": ["T039"], "canonical_name": "positive regulation of membrane hyperpolarization", "definition": "Any process that activates or increases the frequency, rate or extent of membrane hyperpolarization. [GO_REF:0000058, GOC:TermGenie, PMID:23223304]"}
{"concept_id": "C3822913", "aliases": [], "types": ["T039"], "canonical_name": "activation of membrane hyperpolarization"}
{"concept_id": "C3822914", "aliases": ["1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolism"], "types": ["T044"], "canonical_name": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process", "definition": "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153]"}
{"concept_id": "C3822915", "aliases": ["1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism", "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation"], "types": ["T044"], "canonical_name": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153]"}
{"concept_id": "C3822916", "aliases": ["1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation", "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism", "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis"], "types": ["T044"], "canonical_name": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153]"}
{"concept_id": "C3822917", "aliases": ["cilium basal body of kinocilium", "kinocilium basal body", "ciliary basal body of kinocilium", "cilial basal body of kinocilium", "kinocilium ciliary basal body", "microtubule basal body of kinocilium", "kinocilial basal body"], "types": ["T026"], "canonical_name": "kinociliary basal body", "definition": "A ciliary basal body that is part of a kinocilium. [GO_REF:0000064, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:15855039, PMID:15882574]"}
{"concept_id": "C3822918", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell differentiation involved in thymus development", "definition": "Any neural crest cell differentiation that is involved in thymus development. [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317, PMID:18292542]"}
{"concept_id": "C3822919", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell differentiation involved in parathyroid gland development", "definition": "Any neural crest cell differentiation that is involved in parathyroid gland development. [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317]"}
{"concept_id": "C3822920", "aliases": ["propan-2-ol metabolism", "Isopropanol metabolic process", "Isopropyl alcohol metabolic process"], "types": ["T044"], "canonical_name": "propan-2-ol metabolic process", "definition": "The chemical reactions and pathways involving propan-2-ol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237]"}
{"concept_id": "C3822921", "aliases": ["propan-2-ol formation", "propan-2-ol biosynthesis", "propan-2-ol anabolism", "Isopropyl alcohol biosynthetic process", "propan-2-ol synthesis", "Isopropanol biosynthetic process"], "types": ["T044"], "canonical_name": "propan-2-ol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of propan-2-ol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237]"}
{"concept_id": "C3822922", "aliases": ["regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation", "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism"], "types": ["T044"], "canonical_name": "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "definition": "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]"}
{"concept_id": "C3822923", "aliases": ["downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism", "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism", "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation", "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation", "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism", "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation", "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism", "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation"], "types": ["T044"], "canonical_name": "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]"}
{"concept_id": "C3822924", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown"}
{"concept_id": "C3822925", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process"}
{"concept_id": "C3822926", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism"}
{"concept_id": "C3822927", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation"}
{"concept_id": "C3822928", "aliases": ["up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism", "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism", "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism", "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation", "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation", "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation", "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown", "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism", "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation"], "types": ["T044"], "canonical_name": "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]"}
{"concept_id": "C3822929", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown"}
{"concept_id": "C3822930", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process"}
{"concept_id": "C3822931", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism"}
{"concept_id": "C3822932", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation"}
{"concept_id": "C3822933", "aliases": ["tertiary alcohol metabolism"], "types": ["T044"], "canonical_name": "tertiary alcohol metabolic process", "definition": "The chemical reactions and pathways involving tertiary alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]"}
{"concept_id": "C3822934", "aliases": ["tertiary alcohol synthesis", "tertiary alcohol biosynthesis", "tertiary alcohol anabolism", "tertiary alcohol formation"], "types": ["T044"], "canonical_name": "tertiary alcohol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tertiary alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]"}
{"concept_id": "C3822935", "aliases": ["regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis", "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism", "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation"], "types": ["T040"], "canonical_name": "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]"}
{"concept_id": "C3822936", "aliases": ["down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation", "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism", "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation", "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis", "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis", "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis", "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism", "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation", "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism", "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation", "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis", "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism"], "types": ["T040"], "canonical_name": "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]"}
{"concept_id": "C3822937", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism"}
{"concept_id": "C3822938", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis"}
{"concept_id": "C3822939", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"}
{"concept_id": "C3822940", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation"}
{"concept_id": "C3822941", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis"}
{"concept_id": "C3822942", "aliases": ["positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis", "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis", "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism", "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis", "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism", "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation", "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism", "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis", "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation", "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism", "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis", "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation", "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation"], "types": ["T040"], "canonical_name": "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]"}
{"concept_id": "C3822943", "aliases": [], "types": ["T040"], "canonical_name": "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism"}
{"concept_id": "C3822944", "aliases": [], "types": ["T040"], "canonical_name": "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis"}
{"concept_id": "C3822945", "aliases": [], "types": ["T040"], "canonical_name": "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"}
{"concept_id": "C3822946", "aliases": [], "types": ["T040"], "canonical_name": "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation"}
{"concept_id": "C3822947", "aliases": [], "types": ["T040"], "canonical_name": "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis"}
{"concept_id": "C3822953", "aliases": ["secondary alcohol metabolism"], "types": ["T044"], "canonical_name": "secondary alcohol metabolic process", "definition": "The chemical reactions and pathways involving secondary alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]"}
{"concept_id": "C3822954", "aliases": ["secondary alcohol formation", "secondary alcohol biosynthesis", "secondary alcohol anabolism", "secondary alcohol synthesis"], "types": ["T044"], "canonical_name": "secondary alcohol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of secondary alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]"}
{"concept_id": "C3822955", "aliases": ["aromatic primary alcohol metabolism"], "types": ["T044"], "canonical_name": "aromatic primary alcohol metabolic process", "definition": "The chemical reactions and pathways involving aromatic primary alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878]"}
{"concept_id": "C3822956", "aliases": ["aromatic primary alcohol synthesis", "aromatic primary alcohol anabolism", "aromatic primary alcohol biosynthesis", "aromatic primary alcohol formation"], "types": ["T044"], "canonical_name": "aromatic primary alcohol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of aromatic primary alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878]"}
{"concept_id": "C3822957", "aliases": [], "types": ["T043"], "canonical_name": "calcium ion import into cytosol", "definition": "The directed movement of calcium ion into a cytosol. [GO_REF:0000075, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3822958", "aliases": [], "types": ["T043"], "canonical_name": "calcium import into cytosol"}
{"concept_id": "C3822959", "aliases": ["protein localisation to prospore membrane", "protein localization in prospore membrane", "protein localisation in prospore membrane"], "types": ["T043"], "canonical_name": "protein localization to prospore membrane", "definition": "A process in which a protein is transported to, or maintained in, a location within a prospore membrane. [GO_REF:0000087, GOC:dph, GOC:TermGenie, PMID:24036347]"}
{"concept_id": "C3822961", "aliases": ["regulation of glucose mediated signalling"], "types": ["T044"], "canonical_name": "regulation of glucose mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of glucose mediated signaling pathway. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933]"}
{"concept_id": "C3822962", "aliases": ["down-regulation of glucose mediated signaling pathway", "downregulation of glucose mediated signalling", "downregulation of glucose mediated signaling pathway", "down regulation of glucose mediated signaling pathway", "down-regulation of glucose mediated signalling", "negative regulation of glucose mediated signalling", "down regulation of glucose mediated signalling"], "types": ["T044"], "canonical_name": "negative regulation of glucose mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucose mediated signaling pathway. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933]"}
{"concept_id": "C3822963", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucose mediated signaling pathway"}
{"concept_id": "C3822964", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucose mediated signalling"}
{"concept_id": "C3822965", "aliases": ["up regulation of glucose mediated signaling pathway", "upregulation of glucose mediated signalling", "up-regulation of glucose mediated signaling pathway", "up regulation of glucose mediated signalling", "up-regulation of glucose mediated signalling", "positive regulation of glucose mediated signalling", "upregulation of glucose mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of glucose mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of glucose mediated signaling pathway. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933]"}
{"concept_id": "C3822966", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucose mediated signaling pathway"}
{"concept_id": "C3822967", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucose mediated signalling"}
{"concept_id": "C3822968", "aliases": ["regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine", "regulation of peptidyl-cysteine S-palmitoylation", "regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "regulation of peptidyl-L-cysteine S-palmitoylation", "definition": "Any process that modulates the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation. [GO_REF:0000058, GOC:TermGenie, PMID:23444136]"}
{"concept_id": "C3822969", "aliases": ["negative regulation of peptidyl-cysteine S-palmitoylation", "down-regulation of peptidyl-L-cysteine S-palmitoylation", "downregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine", "down regulation of peptidyl-L-cysteine S-palmitoylation", "down regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "down regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine", "down-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "downregulation of peptidyl-cysteine S-palmitoylation", "negative regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "down-regulation of peptidyl-cysteine S-palmitoylation", "downregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "negative regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine", "downregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "down regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine", "down-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine", "downregulation of peptidyl-L-cysteine S-palmitoylation", "down regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "negative regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "negative regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine", "down regulation of peptidyl-cysteine S-palmitoylation", "downregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine", "down-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "down-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "negative regulation of peptidyl-L-cysteine S-palmitoylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation. [GO_REF:0000058, GOC:TermGenie, PMID:23444136]"}
{"concept_id": "C3822970", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptidyl-cysteine S-palmitoylation"}
{"concept_id": "C3822971", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptidyl-L-cysteine S-palmitoylation"}
{"concept_id": "C3822972", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine"}
{"concept_id": "C3822973", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine"}
{"concept_id": "C3822974", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine"}
{"concept_id": "C3822975", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine"}
{"concept_id": "C3822976", "aliases": ["up-regulation of peptidyl-L-cysteine S-palmitoylation", "positive regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "up-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine", "up-regulation of peptidyl-cysteine S-palmitoylation", "up regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "upregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "positive regulation of peptidyl-cysteine S-palmitoylation", "up regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine", "upregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "upregulation of peptidyl-cysteine S-palmitoylation", "positive regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "positive regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine", "up regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine", "up regulation of peptidyl-L-cysteine S-palmitoylation", "upregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine", "upregulation of peptidyl-L-cysteine S-palmitoylation", "positive regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine", "up regulation of peptidyl-cysteine S-palmitoylation", "up regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "up-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine", "up-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine", "up-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine", "upregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine"], "types": ["T044"], "canonical_name": "positive regulation of peptidyl-L-cysteine S-palmitoylation", "definition": "Any process that activates or increases the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation. [GO_REF:0000058, GOC:TermGenie, PMID:23444136]"}
{"concept_id": "C3822977", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptidyl-cysteine S-palmitoylation"}
{"concept_id": "C3822978", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptidyl-L-cysteine S-palmitoylation"}
{"concept_id": "C3822979", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine"}
{"concept_id": "C3822980", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine"}
{"concept_id": "C3822981", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine"}
{"concept_id": "C3822982", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine"}
{"concept_id": "C3822983", "aliases": ["response to 2-methylpropan-1-ol"], "types": ["T043"], "canonical_name": "response to isobutanol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isobutanol stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:24014527]"}
{"concept_id": "C3822985", "aliases": ["regulation of axon pathfinding"], "types": ["T042"], "canonical_name": "regulation of axon guidance", "definition": "Any process that modulates the frequency, rate or extent of axon guidance. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]"}
{"concept_id": "C3822986", "aliases": [], "types": ["T042"], "canonical_name": "regulation of axon chemotaxis"}
{"concept_id": "C3822987", "aliases": [], "types": ["T042"], "canonical_name": "regulation of axon growth cone guidance"}
{"concept_id": "C3822988", "aliases": ["downregulation of axon guidance", "downregulation of axon pathfinding", "down regulation of axon guidance", "down regulation of axon pathfinding", "down-regulation of axon pathfinding", "negative regulation of axon pathfinding", "down-regulation of axon guidance"], "types": ["T043"], "canonical_name": "negative regulation of axon guidance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]"}
{"concept_id": "C3822989", "aliases": ["down-regulation of axon chemotaxis"], "types": ["T043"], "canonical_name": "down regulation of axon chemotaxis"}
{"concept_id": "C3822990", "aliases": ["down-regulation of axon growth cone guidance"], "types": ["T043"], "canonical_name": "down regulation of axon growth cone guidance"}
{"concept_id": "C3822991", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of axon chemotaxis"}
{"concept_id": "C3822992", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of axon growth cone guidance"}
{"concept_id": "C3822993", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axon chemotaxis"}
{"concept_id": "C3822994", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axon growth cone guidance"}
{"concept_id": "C3822995", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axon guidance"}
{"concept_id": "C3822996", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axon pathfinding"}
{"concept_id": "C3822997", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of axon chemotaxis"}
{"concept_id": "C3822998", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of axon growth cone guidance"}
{"concept_id": "C3822999", "aliases": ["up regulation of axon guidance", "up-regulation of axon pathfinding", "upregulation of axon pathfinding", "positive regulation of axon pathfinding", "up regulation of axon pathfinding", "up-regulation of axon guidance", "upregulation of axon guidance"], "types": ["T043"], "canonical_name": "positive regulation of axon guidance", "definition": "Any process that activates or increases the frequency, rate or extent of axon guidance. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]"}
{"concept_id": "C3823000", "aliases": [], "types": ["T043"], "canonical_name": "activation of axon chemotaxis"}
{"concept_id": "C3823001", "aliases": [], "types": ["T043"], "canonical_name": "activation of axon growth cone guidance"}
{"concept_id": "C3823002", "aliases": [], "types": ["T043"], "canonical_name": "activation of axon guidance"}
{"concept_id": "C3823003", "aliases": [], "types": ["T043"], "canonical_name": "activation of axon pathfinding"}
{"concept_id": "C3823004", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of axon chemotaxis"}
{"concept_id": "C3823005", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of axon growth cone guidance"}
{"concept_id": "C3823006", "aliases": ["up-regulation of axon chemotaxis"], "types": ["T043"], "canonical_name": "up regulation of axon chemotaxis"}
{"concept_id": "C3823007", "aliases": ["up-regulation of axon growth cone guidance"], "types": ["T043"], "canonical_name": "up regulation of axon growth cone guidance"}
{"concept_id": "C3823008", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of axon chemotaxis"}
{"concept_id": "C3823009", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of axon growth cone guidance"}
{"concept_id": "C3823010", "aliases": ["CO2 binding"], "types": ["T044"], "canonical_name": "carbon dioxide binding", "definition": "Binding to carbon dioxide. [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:15491402]"}
{"concept_id": "C3823011", "aliases": ["microtubule basal body of left anterior cilium", "microtubule basal body of left anterior flagellum", "ciliary basal body of left anterior cilium", "left anterior flagellum ciliary basal body", "cilial basal body of left anterior cilium", "cilium basal body of left anterior flagellum", "ciliary basal body of left anterior flagellum", "cilium basal body of left anterior cilium", "cilial basal body of left anterior flagellum"], "types": ["T026"], "canonical_name": "left anterior basal body", "definition": "Any ciliary basal body that is part of a left anterior flagellum found in Giardia species (trophozoite stage). [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3823012", "aliases": ["ciliary basal body of right anterior flagellum", "microtubule basal body of right anterior cilium", "cilium basal body of right anterior cilium", "cilial basal body of right anterior cilium", "cilium basal body of right anterior flagellum", "ciliary basal body of right anterior cilium", "right anterior flagellum ciliary basal body", "microtubule basal body of right anterior flagellum", "cilial basal body of right anterior flagellum"], "types": ["T026"], "canonical_name": "right anterior basal body", "definition": "Any ciliary basal body that is part of a right anterior flagellum found in Giardia species (trophozoite stage). [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3823013", "aliases": ["ciliary basal body of left posterolateral flagellum", "ciliary basal body of left posterolateral cilium", "microtubule basal body of left posterolateral flagellum", "left posteriolateral flagellum ciliary basal body", "cilium basal body of left posteriolateral flagellum", "cilial basal body of left posteriolateral cilium", "microtubule basal body of left posteriolateral cilium", "cilium basal body of left posterolateral cilium", "microtubule basal body of left posterolateral cilium", "microtubule basal body of left posteriolateral flagellum", "ciliary basal body of left posteriolateral flagellum", "cilial basal body of left posterolateral cilium", "cilial basal body of left posterolateral flagellum", "cilium basal body of left posteriolateral cilium", "ciliary basal body of left posteriolateral cilium", "cilium basal body of left posterolateral flagellum", "cilial basal body of left posteriolateral flagellum"], "types": ["T026"], "canonical_name": "left posteriolateral basal body", "definition": "Any ciliary basal body that is part of a left posteriolateral flagellum found in Giardia species (trophozoite stage). [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3823014", "aliases": ["cilial basal body of right posterolateral flagellum", "microtubule basal body of right posteriolateral cilium", "ciliary basal body of right posteriolateral flagellum", "right posteriolateral flagellum ciliary basal body", "microtubule basal body of right posterolateral flagellum", "ciliary basal body of right posterolateral cilium", "cilium basal body of right posterolateral cilium", "cilial basal body of right posteriolateral flagellum", "cilium basal body of right posteriolateral flagellum", "microtubule basal body of right posterolateral cilium", "microtubule basal body of right posteriolateral flagellum", "cilial basal body of right posterolateral cilium", "cilial basal body of right posteriolateral cilium", "cilium basal body of right posterolateral flagellum", "cilium basal body of right posteriolateral cilium", "ciliary basal body of right posterolateral flagellum", "ciliary basal body of right posteriolateral cilium"], "types": ["T026"], "canonical_name": "right posteriolateral basal body", "definition": "Any ciliary basal body that is part of a right posteriolateral flagellum found in Giardia species (trophozoite stage). [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3823015", "aliases": ["cilium basal body of left ventral cilium", "left ventral flagellum ciliary basal body", "ciliary basal body of left ventral flagellum", "cilium basal body of left ventral flagellum", "cilial basal body of left ventral flagellum", "microtubule basal body of left ventral flagellum", "microtubule basal body of left ventral cilium", "ciliary basal body of left ventral cilium", "cilial basal body of left ventral cilium"], "types": ["T026"], "canonical_name": "left ventral basal body", "definition": "Any ciliary basal body that is part of a left ventral flagellum found in Giardia species (trophozoite stage). [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3823016", "aliases": ["microtubule basal body of right ventral cilium", "cilium basal body of right ventral cilium", "right ventral flagellum ciliary basal body", "cilial basal body of right ventral cilium", "ciliary basal body of right ventral cilium", "cilial basal body of right ventral flagellum", "cilium basal body of right ventral flagellum", "microtubule basal body of right ventral flagellum", "ciliary basal body of right ventral flagellum"], "types": ["T026"], "canonical_name": "right ventral basal body", "definition": "Any ciliary basal body that is part of a right ventral flagellum found in Giardia species (trophozoite stage). [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3823017", "aliases": ["cilium basal body of left caudal cilium", "microtubule basal body of left caudal cilium", "microtubule basal body of left caudal flagellum", "cilial basal body of left caudal flagellum", "left caudal flagellum ciliary basal body", "cilium basal body of left caudal flagellum", "ciliary basal body of left caudal flagellum", "cilial basal body of left caudal cilium", "ciliary basal body of left caudal cilium"], "types": ["T026"], "canonical_name": "left caudal basal body", "definition": "Any ciliary basal body that is part of a left caudal flagellum found in Giardia species (trophozoite stage). [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3823018", "aliases": ["microtubule basal body of right caudal cilium", "ciliary basal body of right caudal cilium", "cilium basal body of right caudal flagellum", "ciliary basal body of right caudal flagellum", "microtubule basal body of right caudal flagellum", "right caudal flagellum ciliary basal body", "cilial basal body of right caudal cilium", "cilium basal body of right caudal cilium", "cilial basal body of right caudal flagellum"], "types": ["T026"], "canonical_name": "right caudal basal body", "definition": "Any ciliary basal body that is part of a right caudal flagellum found in Giardia species (trophozoite stage). [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]"}
{"concept_id": "C3823019", "aliases": ["down regulation of RNA formation", "negative regulation of RNA anabolism", "down regulation of RNA biosynthetic process", "down-regulation of RNA biosynthesis", "negative regulation of RNA formation", "down regulation of RNA anabolism", "down-regulation of RNA formation", "negative regulation of RNA biosynthesis", "downregulation of RNA biosynthesis", "down-regulation of RNA biosynthetic process", "downregulation of RNA anabolism", "down regulation of RNA biosynthesis", "down-regulation of RNA synthesis", "downregulation of RNA formation", "downregulation of RNA biosynthetic process", "downregulation of RNA synthesis", "down-regulation of RNA anabolism", "down regulation of RNA synthesis", "negative regulation of RNA synthesis"], "types": ["T040"], "canonical_name": "negative regulation of RNA biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. [GO:jl, GO_REF:0000058, GOC:TermGenie]"}
{"concept_id": "C3823020", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of RNA anabolism"}
{"concept_id": "C3823021", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of RNA biosynthesis"}
{"concept_id": "C3823022", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of RNA biosynthetic process"}
{"concept_id": "C3823023", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of RNA formation"}
{"concept_id": "C3823024", "aliases": ["up regulation of RNA biosynthesis", "upregulation of RNA biosynthetic process", "upregulation of RNA formation", "up regulation of RNA biosynthetic process", "up regulation of RNA formation", "up-regulation of RNA formation", "positive regulation of RNA anabolism", "up regulation of RNA anabolism", "up-regulation of RNA biosynthesis", "up regulation of RNA synthesis", "upregulation of RNA biosynthesis", "up-regulation of RNA synthesis", "upregulation of RNA synthesis", "upregulation of RNA anabolism", "up-regulation of RNA biosynthetic process", "positive regulation of RNA synthesis", "up-regulation of RNA anabolism", "positive regulation of RNA formation", "positive regulation of RNA biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of RNA biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. [GO:jl, GO_REF:0000058, GOC:TermGenie]"}
{"concept_id": "C3823025", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNA anabolism"}
{"concept_id": "C3823026", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNA biosynthesis"}
{"concept_id": "C3823027", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNA biosynthetic process"}
{"concept_id": "C3823028", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNA formation"}
{"concept_id": "C3823029", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNA synthesis"}
{"concept_id": "C3823030", "aliases": ["regulation of replication fork blocking at rDNA repeats", "regulation of replication fork arrest at ribosomal DNA repeats"], "types": ["T043"], "canonical_name": "regulation of replication fork arrest at rDNA repeats", "definition": "Any process that modulates the frequency, rate or extent of replication fork arrest at rDNA repeats. [GO_REF:0000058, GOC:TermGenie, PMID:23260662]"}
{"concept_id": "C3823031", "aliases": ["protein localisation in centromeric heterochromatin"], "types": ["T045"], "canonical_name": "protein localization to pericentric heterochromatin", "definition": "A process in which a protein is transported to, or maintained in the pericentric heterochromatin. [GO_REF:0000087, GOC:TermGenie, PMID:20211136]"}
{"concept_id": "C3823032", "aliases": ["regulation of receptor localisation to synapse"], "types": ["T039"], "canonical_name": "regulation of receptor localization to synapse", "definition": "Any process that modulates the frequency, rate or extent of receptor localization to synapse. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]"}
{"concept_id": "C3823033", "aliases": ["negative regulation of receptor localisation to synapse", "down regulation of receptor localisation to synapse", "down regulation of receptor localization to synapse", "downregulation of receptor localisation to synapse", "down-regulation of receptor localization to synapse", "downregulation of receptor localization to synapse", "down-regulation of receptor localisation to synapse"], "types": ["T039"], "canonical_name": "negative regulation of receptor localization to synapse", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]"}
{"concept_id": "C3823034", "aliases": ["inhibition of receptor localization to synapse"], "types": ["T039"], "canonical_name": "inhibition of receptor localisation to synapse"}
{"concept_id": "C3823035", "aliases": ["positive regulation of receptor localisation to synapse", "up-regulation of receptor localization to synapse", "up regulation of receptor localisation to synapse", "upregulation of receptor localisation to synapse", "upregulation of receptor localization to synapse", "up-regulation of receptor localisation to synapse", "up regulation of receptor localization to synapse"], "types": ["T039"], "canonical_name": "positive regulation of receptor localization to synapse", "definition": "Any process that activates or increases the frequency, rate or extent of receptor localization to synapse. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]"}
{"concept_id": "C3823036", "aliases": ["activation of receptor localization to synapse"], "types": ["T039"], "canonical_name": "activation of receptor localisation to synapse"}
{"concept_id": "C3823037", "aliases": ["mitochondrion outer membrane permeabilization involved in programmed cell death", "positive regulation of transport across mitochondrial membrane involved in programmed cell death", "mitochondrial outer membrane permeabilization during programmed cell death", "positive regulation of mitochondrial membrane permeability involved in PCD", "positive regulation of mitochondrial membrane permeability involved in programmed cell death", "positive regulation of transport across mitochondrial membrane involved in PCD"], "types": ["T043"], "canonical_name": "mitochondrial outer membrane permeabilization involved in programmed cell death", "definition": "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process. [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie, PMID:20151314]"}
{"concept_id": "C3823038", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in caspase-independent apoptosis"}
{"concept_id": "C3823039", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in caspase-independent cell death"}
{"concept_id": "C3823040", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death"}
{"concept_id": "C3823041", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death"}
{"concept_id": "C3823042", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in PCD"}
{"concept_id": "C3823043", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in programmed cell death"}
{"concept_id": "C3823044", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeability transition involved in regulated cell death"}
{"concept_id": "C3823045", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in caspase-independent apoptosis"}
{"concept_id": "C3823046", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in caspase-independent cell death"}
{"concept_id": "C3823047", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death"}
{"concept_id": "C3823048", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death"}
{"concept_id": "C3823049", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in PCD"}
{"concept_id": "C3823050", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in programmed cell death"}
{"concept_id": "C3823051", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane permeabilization involved in regulated cell death"}
{"concept_id": "C3823052", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in caspase-independent apoptosis"}
{"concept_id": "C3823053", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in caspase-independent cell death"}
{"concept_id": "C3823054", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in non-apoptotic programmed cell death"}
{"concept_id": "C3823055", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in nonapoptotic programmed cell death"}
{"concept_id": "C3823056", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in PCD"}
{"concept_id": "C3823057", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in programmed cell death"}
{"concept_id": "C3823058", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial permeability transition involved in regulated cell death"}
{"concept_id": "C3823059", "aliases": [], "types": ["T043"], "canonical_name": "MPT involved in caspase-independent apoptosis"}
{"concept_id": "C3823060", "aliases": [], "types": ["T043"], "canonical_name": "MPT involved in caspase-independent cell death"}
{"concept_id": "C3823061", "aliases": [], "types": ["T043"], "canonical_name": "MPT involved in non-apoptotic programmed cell death"}
{"concept_id": "C3823062", "aliases": [], "types": ["T043"], "canonical_name": "MPT involved in nonapoptotic programmed cell death"}
{"concept_id": "C3823063", "aliases": [], "types": ["T043"], "canonical_name": "MPT involved in PCD"}
{"concept_id": "C3823064", "aliases": [], "types": ["T043"], "canonical_name": "MPT involved in programmed cell death"}
{"concept_id": "C3823065", "aliases": [], "types": ["T043"], "canonical_name": "MPT involved in regulated cell death"}
{"concept_id": "C3823066", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis"}
{"concept_id": "C3823067", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death"}
{"concept_id": "C3823068", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death"}
{"concept_id": "C3823069", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death"}
{"concept_id": "C3823070", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial membrane permeability involved in regulated cell death"}
{"concept_id": "C3823071", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis"}
{"concept_id": "C3823072", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death"}
{"concept_id": "C3823073", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death"}
{"concept_id": "C3823074", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death"}
{"concept_id": "C3823075", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across mitochondrial membrane involved in regulated cell death"}
{"concept_id": "C3823076", "aliases": ["glucosidase complex location"], "types": ["T026"], "canonical_name": "glucosidase complex", "definition": "A protein complex which is capable of glucosidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932]"}
{"concept_id": "C3823077", "aliases": ["regulation of NAD metabolism", "regulation of nicotinamide adenine dinucleotide metabolism", "regulation of oxidized NAD metabolism", "regulation of oxidized nicotinamide adenine dinucleotide metabolic process", "regulation of NAD (oxidized) metabolic process", "regulation of NAD (oxidized) metabolism", "regulation of nicotinamide adenine dinucleotide metabolic process", "regulation of oxidized nicotinamide adenine dinucleotide metabolism", "regulation of oxidized NAD metabolic process"], "types": ["T044"], "canonical_name": "regulation of NAD metabolic process", "definition": "Any process that modulates the frequency, rate or extent of NAD metabolic process. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558]"}
{"concept_id": "C3823078", "aliases": ["downregulation of oxidized nicotinamide adenine dinucleotide metabolism", "downregulation of NAD metabolism", "negative regulation of oxidized nicotinamide adenine dinucleotide metabolism", "down regulation of nicotinamide adenine dinucleotide metabolism", "negative regulation of NAD (oxidized) metabolism", "down-regulation of nicotinamide adenine dinucleotide metabolism", "downregulation of NAD (oxidized) metabolic process", "down-regulation of oxidized NAD metabolism", "downregulation of nicotinamide adenine dinucleotide metabolic process", "down regulation of NAD metabolism", "down-regulation of oxidized nicotinamide adenine dinucleotide metabolic process", "negative regulation of NAD metabolism", "down regulation of NAD metabolic process", "downregulation of NAD (oxidized) metabolism", "down regulation of oxidized NAD metabolism", "down-regulation of oxidized nicotinamide adenine dinucleotide metabolism", "down regulation of oxidized NAD metabolic process", "down regulation of NAD (oxidized) metabolism", "down regulation of oxidized nicotinamide adenine dinucleotide metabolic process", "down regulation of oxidized nicotinamide adenine dinucleotide metabolism", "down-regulation of oxidized NAD metabolic process", "negative regulation of nicotinamide adenine dinucleotide metabolism", "downregulation of oxidized nicotinamide adenine dinucleotide metabolic process", "down-regulation of NAD (oxidized) metabolic process", "down regulation of NAD (oxidized) metabolic process", "negative regulation of oxidized NAD metabolic process", "negative regulation of oxidized nicotinamide adenine dinucleotide metabolic process", "negative regulation of nicotinamide adenine dinucleotide metabolic process", "down-regulation of NAD metabolism", "downregulation of nicotinamide adenine dinucleotide metabolism", "downregulation of oxidized NAD metabolism", "negative regulation of oxidized NAD metabolism", "down-regulation of nicotinamide adenine dinucleotide metabolic process", "down-regulation of NAD (oxidized) metabolism", "down-regulation of NAD metabolic process", "downregulation of oxidized NAD metabolic process", "downregulation of NAD metabolic process", "down regulation of nicotinamide adenine dinucleotide metabolic process", "negative regulation of NAD (oxidized) metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of NAD metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of NAD metabolic process. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558]"}
{"concept_id": "C3823079", "aliases": ["down-regulation of NAD phosphorylation and dephosphorylation"], "types": ["T043"], "canonical_name": "down regulation of NAD phosphorylation and dephosphorylation"}
{"concept_id": "C3823080", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of NAD phosphorylation and dephosphorylation"}
{"concept_id": "C3823081", "aliases": ["inhibition of oxidized NAD metabolic process"], "types": ["T043"], "canonical_name": "inhibition of NAD (oxidized) metabolic process"}
{"concept_id": "C3823082", "aliases": ["inhibition of oxidized NAD metabolism"], "types": ["T043"], "canonical_name": "inhibition of NAD (oxidized) metabolism"}
{"concept_id": "C3823083", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of NAD metabolic process"}
{"concept_id": "C3823084", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of NAD metabolism"}
{"concept_id": "C3823085", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of NAD phosphorylation and dephosphorylation"}
{"concept_id": "C3823086", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nicotinamide adenine dinucleotide metabolic process"}
{"concept_id": "C3823087", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nicotinamide adenine dinucleotide metabolism"}
{"concept_id": "C3823088", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of oxidized nicotinamide adenine dinucleotide metabolic process"}
{"concept_id": "C3823089", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of oxidized nicotinamide adenine dinucleotide metabolism"}
{"concept_id": "C3823090", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of NAD phosphorylation and dephosphorylation"}
{"concept_id": "C3823091", "aliases": ["up-regulation of NAD (oxidized) metabolism", "positive regulation of nicotinamide adenine dinucleotide metabolic process", "upregulation of nicotinamide adenine dinucleotide metabolic process", "upregulation of oxidized nicotinamide adenine dinucleotide metabolism", "up-regulation of oxidized NAD metabolism", "up-regulation of NAD (oxidized) metabolic process", "positive regulation of nicotinamide adenine dinucleotide metabolism", "up regulation of NAD (oxidized) metabolism", "up-regulation of NAD metabolism", "upregulation of NAD (oxidized) metabolic process", "upregulation of NAD metabolic process", "up regulation of NAD metabolic process", "up regulation of oxidized nicotinamide adenine dinucleotide metabolism", "positive regulation of oxidized NAD metabolism", "positive regulation of oxidized nicotinamide adenine dinucleotide metabolism", "upregulation of oxidized NAD metabolism", "upregulation of oxidized nicotinamide adenine dinucleotide metabolic process", "up-regulation of oxidized nicotinamide adenine dinucleotide metabolism", "positive regulation of NAD (oxidized) metabolism", "up-regulation of oxidized NAD metabolic process", "up-regulation of oxidized nicotinamide adenine dinucleotide metabolic process", "positive regulation of oxidized NAD metabolic process", "upregulation of NAD (oxidized) metabolism", "up regulation of oxidized nicotinamide adenine dinucleotide metabolic process", "up-regulation of NAD metabolic process", "positive regulation of NAD metabolism", "up regulation of NAD metabolism", "positive regulation of oxidized nicotinamide adenine dinucleotide metabolic process", "up-regulation of nicotinamide adenine dinucleotide metabolism", "up regulation of nicotinamide adenine dinucleotide metabolic process", "up regulation of NAD (oxidized) metabolic process", "up regulation of oxidized NAD metabolic process", "up-regulation of nicotinamide adenine dinucleotide metabolic process", "upregulation of NAD metabolism", "up regulation of nicotinamide adenine dinucleotide metabolism", "upregulation of oxidized NAD metabolic process", "positive regulation of NAD (oxidized) metabolic process", "up regulation of oxidized NAD metabolism", "upregulation of nicotinamide adenine dinucleotide metabolism"], "types": ["T043"], "canonical_name": "positive regulation of NAD metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of NAD metabolic process. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558]"}
{"concept_id": "C3823092", "aliases": ["activation of oxidized NAD metabolic process"], "types": ["T043"], "canonical_name": "activation of NAD (oxidized) metabolic process"}
{"concept_id": "C3823093", "aliases": ["activation of oxidized NAD metabolism"], "types": ["T043"], "canonical_name": "activation of NAD (oxidized) metabolism"}
{"concept_id": "C3823094", "aliases": [], "types": ["T043"], "canonical_name": "activation of NAD metabolic process"}
{"concept_id": "C3823095", "aliases": [], "types": ["T043"], "canonical_name": "activation of NAD metabolism"}
{"concept_id": "C3823096", "aliases": [], "types": ["T043"], "canonical_name": "activation of NAD phosphorylation and dephosphorylation"}
{"concept_id": "C3823097", "aliases": [], "types": ["T043"], "canonical_name": "activation of nicotinamide adenine dinucleotide metabolic process"}
{"concept_id": "C3823098", "aliases": [], "types": ["T043"], "canonical_name": "activation of nicotinamide adenine dinucleotide metabolism"}
{"concept_id": "C3823099", "aliases": [], "types": ["T043"], "canonical_name": "activation of oxidized nicotinamide adenine dinucleotide metabolic process"}
{"concept_id": "C3823100", "aliases": [], "types": ["T043"], "canonical_name": "activation of oxidized nicotinamide adenine dinucleotide metabolism"}
{"concept_id": "C3823101", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of NAD phosphorylation and dephosphorylation"}
{"concept_id": "C3823102", "aliases": ["up-regulation of NAD phosphorylation and dephosphorylation"], "types": ["T043"], "canonical_name": "up regulation of NAD phosphorylation and dephosphorylation"}
{"concept_id": "C3823103", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of NAD phosphorylation and dephosphorylation"}
{"concept_id": "C3823104", "aliases": ["airway basal cell differentiation"], "types": ["T043"], "canonical_name": "respiratory basal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell. [GO_REF:0000086, GOC:TermGenie, MP:0011114, PMID:17909629]"}
{"concept_id": "C3823105", "aliases": [], "types": ["T042"], "canonical_name": "regulation of neuroblast proliferation", "definition": "Any process that modulates the frequency, rate or extent of neuroblast proliferation. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496]"}
{"concept_id": "C3823106", "aliases": ["superoxide dismutase complex location"], "types": ["T026"], "canonical_name": "superoxide dismutase complex", "definition": "A protein complex which is capable of superoxide dismutase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10026301]"}
{"concept_id": "C3823107", "aliases": ["superoxide dismutase copper chaperone complex location"], "types": ["T026"], "canonical_name": "superoxide dismutase copper chaperone complex", "definition": "A protein complex which is capable of superoxide dismutase copper chaperone activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947]"}
{"concept_id": "C3823108", "aliases": ["metallochaperone complex location"], "types": ["T026"], "canonical_name": "metallochaperone complex", "definition": "A protein complex which is capable of metallochaperone activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947]"}
{"concept_id": "C3823109", "aliases": ["glycine degradation to isobutanol", "glycine breakdown to isobutanol", "glycine catabolism to isobutanol"], "types": ["T044"], "canonical_name": "glycine catabolic process to isobutanol", "definition": "The chemical reactions and pathways resulting in the breakdown of glycine to isobutanol. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:23642236]"}
{"concept_id": "C3823110", "aliases": ["valine catabolism to isobutanol", "valine breakdown to isobutanol", "valine degradation to isobutanol"], "types": ["T044"], "canonical_name": "valine catabolic process to isobutanol", "definition": "The chemical reactions and pathways resulting in the breakdown of valine to isobutanol. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:9748245]"}
{"concept_id": "C3823111", "aliases": ["pentose catabolism to butyrate", "pentose breakdown to butyrate", "pentose degradation to butyrate"], "types": ["T044"], "canonical_name": "pentose catabolic process to butyrate", "definition": "The chemical reactions and pathways resulting in the breakdown of pentose to butyrate. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823112", "aliases": ["acidogenesis"], "types": ["T044"], "canonical_name": "acidogenesis"}
{"concept_id": "C3823113", "aliases": ["pentose catabolism to acetate", "pentose breakdown to acetate", "pentose degradation to acetate"], "types": ["T044"], "canonical_name": "pentose catabolic process to acetate", "definition": "The chemical reactions and pathways resulting in the breakdown of pentose to acetate. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823114", "aliases": ["pentose catabolic process to butanol", "pentose degradation to butan-1-ol", "pentose catabolism to butan-1-ol", "pentose catabolic process to 1-butanol", "pentose breakdown to butan-1-ol"], "types": ["T044"], "canonical_name": "pentose catabolic process to butan-1-ol", "definition": "The chemical reactions and pathways resulting in the breakdown of pentose to butan-1-ol. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823115", "aliases": ["solventogenesis"], "types": ["T040"], "canonical_name": "solventogenesis"}
{"concept_id": "C3823116", "aliases": ["pentose breakdown to propan-2-ol", "pentose catabolic process to isopropanol", "pentose catabolic process to isopropyl alcohol", "pentose degradation to propan-2-ol", "pentose catabolism to propan-2-ol"], "types": ["T044"], "canonical_name": "pentose catabolic process to propan-2-ol", "definition": "The chemical reactions and pathways resulting in the breakdown of pentose to propan-2-ol. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823117", "aliases": ["hexose degradation to propan-2-ol", "hexose catabolism to propan-2-ol", "hexose catabolic process to isopropanol", "hexose breakdown to propan-2-ol", "hexose catabolic process to isopropyl alcohol"], "types": ["T044"], "canonical_name": "hexose catabolic process to propan-2-ol", "definition": "The chemical reactions and pathways resulting in the breakdown of hexose to propan-2-ol. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823118", "aliases": ["hexose breakdown to butan-1-ol", "hexose catabolism to butan-1-ol", "hexose catabolic process to butanol", "hexose degradation to butan-1-ol", "hexose catabolic process to 1-butanol"], "types": ["T044"], "canonical_name": "hexose catabolic process to butan-1-ol", "definition": "The chemical reactions and pathways resulting in the breakdown of hexose to butan-1-ol. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823119", "aliases": ["hexose catabolic process to 2-propanone", "hexose catabolism to acetone", "hexose degradation to acetone", "hexose breakdown to acetone"], "types": ["T044"], "canonical_name": "hexose catabolic process to acetone", "definition": "The chemical reactions and pathways resulting in the breakdown of hexose to acetone. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823120", "aliases": ["hexose breakdown to butyrate", "hexose degradation to butyrate", "hexose catabolism to butyrate"], "types": ["T044"], "canonical_name": "hexose catabolic process to butyrate", "definition": "The chemical reactions and pathways resulting in the breakdown of hexose to butyrate. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823121", "aliases": ["hexose degradation to acetate", "hexose catabolism to acetate", "hexose breakdown to acetate"], "types": ["T044"], "canonical_name": "hexose catabolic process to acetate", "definition": "The chemical reactions and pathways resulting in the breakdown of hexose to acetate. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823122", "aliases": ["hexose degradation to ethanol", "hexose catabolism to ethanol", "hexose breakdown to ethanol"], "types": ["T040"], "canonical_name": "hexose catabolic process to ethanol", "definition": "The chemical reactions and pathways resulting in the breakdown of hexose to ethanol. [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]"}
{"concept_id": "C3823123", "aliases": [], "types": ["T043"], "canonical_name": "response to plumbagin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23028742]"}
{"concept_id": "C3823124", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to plumbagin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23028742]"}
{"concept_id": "C3823125", "aliases": ["gamma-aminobutyric acid receptor complex location", "GABA receptor complex location", "gamma-aminobutyric acid receptor complex"], "types": ["T026"], "canonical_name": "GABA receptor complex", "definition": "A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]"}
{"concept_id": "C3823126", "aliases": ["GABA-A receptor complex location"], "types": ["T026"], "canonical_name": "GABA-A receptor complex", "definition": "A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor). [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]"}
{"concept_id": "C3823127", "aliases": ["G-protein coupled GABA receptor complex", "G-protein coupled GABA receptor complex location", "G protein-coupled GABA receptor complex location"], "types": ["T026"], "canonical_name": "G protein-coupled GABA receptor complex", "definition": "A protein complex which is capable of G protein-coupled GABA receptor activity. In human, it is usually a heterodimer composed of GABA-B receptor subunits 1 and 2. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]"}
{"concept_id": "C3823128", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interferon-gamma secretion"}
{"concept_id": "C3823138", "aliases": ["cell cortex of growing cell end"], "types": ["T026"], "canonical_name": "cell cortex of growing cell tip", "definition": "Any cell cortex that is part of a growing cell tip. [GO_REF:0000064, GOC:TermGenie, PMID:24146635]"}
{"concept_id": "C3823139", "aliases": ["down-regulation of prolactin secretion", "downregulation of prolactin secretion", "down regulation of prolactin secretion"], "types": ["T043"], "canonical_name": "negative regulation of prolactin secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion. [GO_REF:0000058, GOC:TermGenie, PMID:16159377]"}
{"concept_id": "C3823140", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of prolactin secretion"}
{"concept_id": "C3823141", "aliases": ["up regulation of prolactin secretion", "up-regulation of prolactin secretion", "upregulation of prolactin secretion"], "types": ["T043"], "canonical_name": "positive regulation of prolactin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of prolactin secretion. [GO_REF:0000058, GOC:TermGenie, PMID:16159377]"}
{"concept_id": "C3823142", "aliases": [], "types": ["T043"], "canonical_name": "activation of prolactin secretion"}
{"concept_id": "C3823143", "aliases": ["down regulation of satellite cell proliferation", "down-regulation of satellite cell proliferation", "downregulation of satellite cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of skeletal muscle satellite cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823144", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of satellite cell proliferation"}
{"concept_id": "C3823145", "aliases": ["upregulation of satellite cell proliferation", "up-regulation of satellite cell proliferation", "up regulation of satellite cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of skeletal muscle satellite cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of skeletal muscle satellite cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823146", "aliases": [], "types": ["T043"], "canonical_name": "activation of satellite cell proliferation"}
{"concept_id": "C3823147", "aliases": ["down-regulation of satellite cell differentiation", "downregulation of satellite cell differentiation", "down regulation of satellite cell differentiation"], "types": ["T038"], "canonical_name": "negative regulation of satellite cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823148", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of satellite cell differentiation"}
{"concept_id": "C3823149", "aliases": ["upregulation of satellite cell differentiation", "up regulation of satellite cell differentiation", "up-regulation of satellite cell differentiation"], "types": ["T038"], "canonical_name": "positive regulation of skeletal muscle satellite cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of satellite cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823150", "aliases": [], "types": ["T038"], "canonical_name": "activation of satellite cell differentiation"}
{"concept_id": "C3823151", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of growth factor dependent skeletal muscle satellite cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823152", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of growth factor dependent skeletal muscle satellite cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823153", "aliases": ["down-regulation of proteoglycan biosynthesis", "down regulation of proteoglycan anabolism", "down regulation of proteoglycan biosynthetic process", "downregulation of proteoglycan anabolism", "down regulation of proteoglycan formation", "downregulation of proteoglycan synthesis", "downregulation of proteoglycan biosynthesis", "negative regulation of proteoglycan formation", "down regulation of proteoglycan biosynthesis", "down-regulation of proteoglycan biosynthetic process", "down-regulation of proteoglycan formation", "down regulation of proteoglycan synthesis", "down-regulation of proteoglycan anabolism", "downregulation of proteoglycan biosynthetic process", "negative regulation of proteoglycan anabolism", "down-regulation of proteoglycan synthesis", "negative regulation of proteoglycan biosynthesis", "negative regulation of proteoglycan synthesis", "downregulation of proteoglycan formation"], "types": ["T040"], "canonical_name": "negative regulation of proteoglycan biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823154", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of proteoglycan anabolism"}
{"concept_id": "C3823155", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of proteoglycan biosynthesis"}
{"concept_id": "C3823156", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of proteoglycan biosynthetic process"}
{"concept_id": "C3823157", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of proteoglycan formation"}
{"concept_id": "C3823158", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of proteoglycan synthesis"}
{"concept_id": "C3823159", "aliases": ["upregulation of proteoglycan anabolism", "upregulation of proteoglycan biosynthetic process", "up-regulation of proteoglycan biosynthetic process", "up-regulation of proteoglycan anabolism", "positive regulation of proteoglycan formation", "upregulation of proteoglycan biosynthesis", "up-regulation of proteoglycan formation", "up-regulation of proteoglycan synthesis", "upregulation of proteoglycan formation", "up regulation of proteoglycan synthesis", "up-regulation of proteoglycan biosynthesis", "upregulation of proteoglycan synthesis", "up regulation of proteoglycan formation", "up regulation of proteoglycan biosynthetic process", "positive regulation of proteoglycan synthesis", "positive regulation of proteoglycan anabolism", "up regulation of proteoglycan biosynthesis", "up regulation of proteoglycan anabolism", "positive regulation of proteoglycan biosynthesis"], "types": ["T040"], "canonical_name": "positive regulation of proteoglycan biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823160", "aliases": [], "types": ["T040"], "canonical_name": "activation of proteoglycan anabolism"}
{"concept_id": "C3823161", "aliases": [], "types": ["T040"], "canonical_name": "activation of proteoglycan biosynthesis"}
{"concept_id": "C3823162", "aliases": [], "types": ["T040"], "canonical_name": "activation of proteoglycan biosynthetic process"}
{"concept_id": "C3823163", "aliases": [], "types": ["T040"], "canonical_name": "activation of proteoglycan formation"}
{"concept_id": "C3823164", "aliases": [], "types": ["T040"], "canonical_name": "activation of proteoglycan synthesis"}
{"concept_id": "C3823165", "aliases": ["down-regulation of cartilage cell proliferation", "down regulation of cartilage cell proliferation", "negative regulation of cartilage cell proliferation", "downregulation of cartilage cell proliferation", "down-regulation of chondrocyte cell proliferation", "downregulation of chondrocyte proliferation", "negative regulation of chondrocyte cell proliferation", "down regulation of chondrocyte cell proliferation", "downregulation of chondrocyte cell proliferation", "down regulation of chondrocyte proliferation", "down-regulation of chondrocyte proliferation"], "types": ["T043"], "canonical_name": "negative regulation of chondrocyte proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823166", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cartilage cell proliferation"}
{"concept_id": "C3823167", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chondrocyte cell proliferation"}
{"concept_id": "C3823168", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chondrocyte proliferation"}
{"concept_id": "C3823169", "aliases": ["up regulation of chondrocyte proliferation", "up-regulation of chondrocyte cell proliferation", "positive regulation of cartilage cell proliferation", "up-regulation of cartilage cell proliferation", "upregulation of cartilage cell proliferation", "positive regulation of chondrocyte cell proliferation", "up regulation of cartilage cell proliferation", "up regulation of chondrocyte cell proliferation", "up-regulation of chondrocyte proliferation", "upregulation of chondrocyte cell proliferation", "upregulation of chondrocyte proliferation"], "types": ["T043"], "canonical_name": "positive regulation of chondrocyte proliferation", "definition": "Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823170", "aliases": [], "types": ["T043"], "canonical_name": "activation of cartilage cell proliferation"}
{"concept_id": "C3823171", "aliases": [], "types": ["T043"], "canonical_name": "activation of chondrocyte cell proliferation"}
{"concept_id": "C3823172", "aliases": [], "types": ["T043"], "canonical_name": "activation of chondrocyte proliferation"}
{"concept_id": "C3823173", "aliases": [], "types": ["T040"], "canonical_name": "regulation of growth plate cartilage chondrocyte differentiation", "definition": "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]"}
{"concept_id": "C3823174", "aliases": ["regulation of virion attachment, binding of host cell surface receptor"], "types": ["T038"], "canonical_name": "regulation of receptor-mediated virion attachment to host cell", "definition": "Any process that modulates the frequency, rate or extent of receptor-mediated virion attachment to host cell. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238]"}
{"concept_id": "C3823175", "aliases": ["down-regulation of virion attachment, binding of host cell surface receptor", "down regulation of receptor-mediated virion attachment to host cell", "down-regulation of receptor-mediated virion attachment to host cell", "negative regulation of virion attachment, binding of host cell surface receptor", "down regulation of virion attachment, binding of host cell surface receptor", "downregulation of receptor-mediated virion attachment to host cell", "downregulation of virion attachment, binding of host cell surface receptor"], "types": ["T038"], "canonical_name": "negative regulation of receptor-mediated virion attachment to host cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated virion attachment to host cell. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238]"}
{"concept_id": "C3823176", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of receptor-mediated virion attachment to host cell"}
{"concept_id": "C3823177", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of virion attachment, binding of host cell surface receptor"}
{"concept_id": "C3823178", "aliases": ["up regulation of receptor-mediated virion attachment to host cell", "up-regulation of receptor-mediated virion attachment to host cell", "up-regulation of virion attachment, binding of host cell surface receptor", "positive regulation of virion attachment, binding of host cell surface receptor", "up regulation of virion attachment, binding of host cell surface receptor", "upregulation of receptor-mediated virion attachment to host cell", "upregulation of virion attachment, binding of host cell surface receptor"], "types": ["T038"], "canonical_name": "positive regulation of receptor-mediated virion attachment to host cell", "definition": "Any process that activates or increases the frequency, rate or extent of receptor-mediated virion attachment to host cell. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238]"}
{"concept_id": "C3823179", "aliases": [], "types": ["T038"], "canonical_name": "activation of receptor-mediated virion attachment to host cell"}
{"concept_id": "C3823180", "aliases": [], "types": ["T038"], "canonical_name": "activation of virion attachment, binding of host cell surface receptor"}
{"concept_id": "C3823181", "aliases": ["dendrite filopodium"], "types": ["T026"], "canonical_name": "dendritic filopodium", "definition": "A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines. [GO_REF:0000064, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24464040, Wikipedia:Dendritic_filopodia]"}
{"concept_id": "C3823182", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chondrocyte differentiation involved in endochondral bone morphogenesis", "definition": "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. [GO_REF:0000058, GOC:TermGenie, PMID:8662546]"}
{"concept_id": "C3823192", "aliases": ["programmed cell death by apoptosis involved in development of an anatomical structure", "apoptotic cell death involved in development of an anatomical structure", "apoptotic programmed cell death involved in development of an anatomical structure", "programmed cell death by apoptosis involved in anatomical structure development", "apoptotic process involved in development of an anatomical structure", "apoptotic programmed cell death involved in anatomical structure development", "apoptotic process involved in anatomical structure development", "apoptotic cell death involved in anatomical structure development"], "types": ["T043"], "canonical_name": "apoptotic process involved in development", "definition": "Any apoptotic process that is involved in anatomical structure development. [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie]"}
{"concept_id": "C3823193", "aliases": ["activation of apoptosis involved in anatomical structure development"], "types": ["T043"], "canonical_name": "activation of apoptosis involved in anatomical structure development"}
{"concept_id": "C3823194", "aliases": ["activation of apoptosis involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "activation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C3823195", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis activator activity involved in anatomical structure development"}
{"concept_id": "C3823196", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis activator activity involved in development of an anatomical structure"}
{"concept_id": "C3823197", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in anatomical structure development"}
{"concept_id": "C3823198", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis involved in development of an anatomical structure"}
{"concept_id": "C3823199", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis signaling involved in anatomical structure development"}
{"concept_id": "C3823200", "aliases": [], "types": ["T043"], "canonical_name": "apoptosis signaling involved in development of an anatomical structure"}
{"concept_id": "C3823201", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic program involved in anatomical structure development"}
{"concept_id": "C3823202", "aliases": [], "types": ["T043"], "canonical_name": "apoptotic program involved in development of an anatomical structure"}
{"concept_id": "C3823203", "aliases": [], "types": ["T043"], "canonical_name": "commitment to apoptosis involved in anatomical structure development"}
{"concept_id": "C3823204", "aliases": [], "types": ["T043"], "canonical_name": "commitment to apoptosis involved in development of an anatomical structure"}
{"concept_id": "C3823205", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis by p53 involved in anatomical structure development"}
{"concept_id": "C3823206", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis by p53 involved in development of an anatomical structure"}
{"concept_id": "C3823207", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis involved in anatomical structure development"}
{"concept_id": "C3823208", "aliases": [], "types": ["T043"], "canonical_name": "induction of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C3823209", "aliases": [], "types": ["T043"], "canonical_name": "signaling (initiator) caspase activity involved in anatomical structure development"}
{"concept_id": "C3823210", "aliases": [], "types": ["T043"], "canonical_name": "signaling (initiator) caspase activity involved in development of an anatomical structure"}
{"concept_id": "C3823211", "aliases": [], "types": ["T043"], "canonical_name": "type I programmed cell death involved in anatomical structure development"}
{"concept_id": "C3823212", "aliases": [], "types": ["T043"], "canonical_name": "type I programmed cell death involved in development of an anatomical structure"}
{"concept_id": "C3823213", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lamellipodium organization"}
{"concept_id": "C3823214", "aliases": [], "types": ["T043"], "canonical_name": "activation of lamellipodium organization"}
{"concept_id": "C3823215", "aliases": ["regulation of lens fibre cell differentiation"], "types": ["T043"], "canonical_name": "regulation of lens fiber cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of lens fiber cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]"}
{"concept_id": "C3823216", "aliases": ["downregulation of lens fibre cell differentiation", "down regulation of lens fibre cell differentiation", "down-regulation of lens fiber cell differentiation", "downregulation of lens fiber cell differentiation", "down regulation of lens fiber cell differentiation", "negative regulation of lens fibre cell differentiation", "down-regulation of lens fibre cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of lens fiber cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]"}
{"concept_id": "C3823217", "aliases": ["inhibition of lens fibre cell differentiation"], "types": ["T043"], "canonical_name": "inhibition of lens fiber cell differentiation"}
{"concept_id": "C3823218", "aliases": ["positive regulation of lens fibre cell differentiation", "upregulation of lens fibre cell differentiation", "up-regulation of lens fiber cell differentiation", "up regulation of lens fibre cell differentiation", "up-regulation of lens fibre cell differentiation", "up regulation of lens fiber cell differentiation", "upregulation of lens fiber cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of lens fiber cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]"}
{"concept_id": "C3823219", "aliases": ["activation of lens fibre cell differentiation"], "types": ["T043"], "canonical_name": "activation of lens fiber cell differentiation"}
{"concept_id": "C3823220", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell cycle G2/M phase transition", "definition": "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle. [GO_REF:0000058, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3823221", "aliases": ["downregulation of cell cycle G2/M phase transition", "down-regulation of cell cycle G2/M phase transition", "down regulation of cell cycle G2/M phase transition"], "types": ["T043"], "canonical_name": "negative regulation of cell cycle G2/M phase transition", "definition": "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle. [GO_REF:0000058, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3823222", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell cycle G2/M phase transition"}
{"concept_id": "C3823223", "aliases": ["up-regulation of cell cycle G2/M phase transition", "up regulation of cell cycle G2/M phase transition", "upregulation of cell cycle G2/M phase transition"], "types": ["T043"], "canonical_name": "positive regulation of cell cycle G2/M phase transition", "definition": "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle. [GO_REF:0000058, GOC:jl, GOC:TermGenie]"}
{"concept_id": "C3823224", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell cycle G2/M phase transition"}
{"concept_id": "C3823225", "aliases": [], "types": ["T038"], "canonical_name": "regulation of renal amino acid absorption", "definition": "Any process that modulates the frequency, rate or extent of renal amino acid absorption. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373]"}
{"concept_id": "C3823226", "aliases": ["down-regulation of renal amino acid absorption", "down regulation of renal amino acid absorption", "downregulation of renal amino acid absorption"], "types": ["T039"], "canonical_name": "negative regulation of renal amino acid absorption", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of renal amino acid absorption. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373]"}
{"concept_id": "C3823227", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of renal amino acid absorption"}
{"concept_id": "C3823228", "aliases": ["up-regulation of renal amino acid absorption", "upregulation of renal amino acid absorption", "up regulation of renal amino acid absorption"], "types": ["T039"], "canonical_name": "positive regulation of renal amino acid absorption", "definition": "Any process that activates or increases the frequency, rate or extent of renal amino acid absorption. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373]"}
{"concept_id": "C3823229", "aliases": [], "types": ["T039"], "canonical_name": "activation of renal amino acid absorption"}
{"concept_id": "C3823230", "aliases": ["sulfurated eukaryotic molybdenum cofactor(2-) metabolism"], "types": ["T044"], "canonical_name": "sulfurated eukaryotic molybdenum cofactor(2-) metabolic process", "definition": "The chemical reactions and pathways involving sulfurated eukaryotic molybdenum cofactor(2-). [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600]"}
{"concept_id": "C3823231", "aliases": ["sulfurated eukaryotic molybdenum cofactor(2-) formation", "sulfurated eukaryotic molybdenum cofactor(2-) synthesis", "sulfurated eukaryotic molybdenum cofactor(2-) anabolism", "sulfurated eukaryotic molybdenum cofactor(2-) biosynthesis"], "types": ["T044"], "canonical_name": "sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sulfurated eukaryotic molybdenum cofactor(2-). [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600]"}
{"concept_id": "C3823232", "aliases": ["bis(molybdopterin guanine dinucleotide)molybdenum metabolism"], "types": ["T044"], "canonical_name": "bis(molybdopterin guanine dinucleotide)molybdenum metabolic process", "definition": "The chemical reactions and pathways involving bis(molybdopterin guanine dinucleotide)molybdenum. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]"}
{"concept_id": "C3823233", "aliases": ["bis(molybdopterin guanine dinucleotide)molybdenum synthesis", "bis(molybdopterin guanine dinucleotide)molybdenum biosynthesis", "bis-Mo-molybdopterin-guanine dinucleotide cofactor biosynthetic process", "bis(molybdopterin guanine dinucleotide)molybdenum formation", "bis(molybdopterin guanine dinucleotide)molybdenum anabolism"], "types": ["T044"], "canonical_name": "bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of bis(molybdopterin guanine dinucleotide)molybdenum. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]"}
{"concept_id": "C3823234", "aliases": ["Mo(VI)-molybdopterin cytosine dinucleotide metabolism"], "types": ["T044"], "canonical_name": "Mo(VI)-molybdopterin cytosine dinucleotide metabolic process", "definition": "The chemical reactions and pathways involving Mo(VI)-molybdopterin cytosine dinucleotide. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]"}
{"concept_id": "C3823235", "aliases": ["Mo(VI)-molybdopterin cytosine dinucleotide anabolism", "Mo(VI)-molybdopterin cytosine dinucleotide synthesis", "Mo(VI)-molybdopterin cytosine dinucleotide biosynthesis", "Mo-molybdopterin-cytosine-dinucleotide cofactor biosynthetic process", "Mo(VI)-molybdopterin cytosine dinucleotide formation"], "types": ["T044"], "canonical_name": "Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of Mo(VI)-molybdopterin cytosine dinucleotide. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]"}
{"concept_id": "C3823236", "aliases": ["upregulation of chondrocyte development", "up-regulation of chondrocyte development", "up regulation of chondrocyte development"], "types": ["T043"], "canonical_name": "positive regulation of chondrocyte development", "definition": "Any process that activates or increases the frequency, rate or extent of chondrocyte development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]"}
{"concept_id": "C3823237", "aliases": [], "types": ["T043"], "canonical_name": "activation of chondrocyte development"}
{"concept_id": "C3823238", "aliases": [], "types": ["T040"], "canonical_name": "regulation of embryonic skeletal joint development", "definition": "Any process that modulates the frequency, rate or extent of embryonic skeletal joint development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]"}
{"concept_id": "C3823239", "aliases": ["downregulation of embryonic skeletal joint development", "down regulation of embryonic skeletal joint development", "down-regulation of embryonic skeletal joint development"], "types": ["T039"], "canonical_name": "negative regulation of embryonic skeletal joint development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic skeletal joint development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]"}
{"concept_id": "C3823240", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of embryonic skeletal joint development"}
{"concept_id": "C3823241", "aliases": ["upregulation of embryonic skeletal joint development", "up-regulation of embryonic skeletal joint development", "up regulation of embryonic skeletal joint development"], "types": ["T039"], "canonical_name": "positive regulation of embryonic skeletal joint development", "definition": "Any process that activates or increases the frequency, rate or extent of embryonic skeletal joint development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]"}
{"concept_id": "C3823242", "aliases": [], "types": ["T039"], "canonical_name": "activation of embryonic skeletal joint development"}
{"concept_id": "C3823244", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle satellite cell migration", "definition": "The orderly movement of a skeletal muscle satellite cell from one site to another. Migration of these cells is a key step in the process of growth and repair of skeletal muscle cells. [GO_REF:0000091, GOC:mr, GOC:TermGenie, PMID:17996437, PMID:19609936]"}
{"concept_id": "C3823245", "aliases": ["isoprenoid biosynthesis via mevalonate", "isoprenoid synthesis via mevalonate", "isoprenoid anabolism via mevalonate", "isoprenoid formation via mevalonate"], "types": ["T044"], "canonical_name": "isoprenoid biosynthetic process via mevalonate", "definition": "The chemical reactions and pathways resulting in the formation of isoprenoid via mevalonate. [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:11078528]"}
{"concept_id": "C3823246", "aliases": ["isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate", "isoprenoid formation via 1-deoxy-D-xylulose 5-phosphate", "isoprenoid anabolism via 1-deoxy-D-xylulose 5-phosphate", "isoprenoid synthesis via 1-deoxy-D-xylulose 5-phosphate"], "types": ["T044"], "canonical_name": "isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate", "definition": "The chemical reactions and pathways resulting in the formation of isoprenoid via 1-deoxy-D-xylulose 5-phosphate. [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:23746261]"}
{"concept_id": "C3823247", "aliases": ["regulation of choline acetyltransferase activity", "regulation of CHOACTase activity", "regulation of acetyl-CoA:choline O-acetyltransferase activity", "regulation of choline acetylase activity"], "types": ["T044"], "canonical_name": "regulation of choline O-acetyltransferase activity", "definition": "Any process that modulates the frequency, rate or extent of choline O-acetyltransferase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634]"}
{"concept_id": "C3823248", "aliases": ["downregulation of choline acetylase activity", "down regulation of choline O-acetyltransferase activity", "downregulation of choline O-acetyltransferase activity", "down-regulation of acetyl-CoA:choline O-acetyltransferase activity", "negative regulation of choline acetylase activity", "down-regulation of CHOACTase activity", "down-regulation of choline acetyltransferase activity", "down regulation of CHOACTase activity", "downregulation of CHOACTase activity", "down-regulation of choline O-acetyltransferase activity", "negative regulation of choline acetyltransferase activity", "downregulation of choline acetyltransferase activity", "down regulation of acetyl-CoA:choline O-acetyltransferase activity", "negative regulation of acetyl-CoA:choline O-acetyltransferase activity", "down regulation of choline acetyltransferase activity", "negative regulation of CHOACTase activity", "down-regulation of choline acetylase activity", "downregulation of acetyl-CoA:choline O-acetyltransferase activity", "down regulation of choline acetylase activity"], "types": ["T044"], "canonical_name": "negative regulation of choline O-acetyltransferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of choline O-acetyltransferase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634]"}
{"concept_id": "C3823249", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acetyl-CoA:choline O-acetyltransferase activity"}
{"concept_id": "C3823250", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CHOACTase activity"}
{"concept_id": "C3823251", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of choline acetylase activity"}
{"concept_id": "C3823252", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of choline acetyltransferase activity"}
{"concept_id": "C3823253", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of choline O-acetyltransferase activity"}
{"concept_id": "C3823254", "aliases": ["upregulation of choline O-acetyltransferase activity", "upregulation of choline acetyltransferase activity", "positive regulation of CHOACTase activity", "up-regulation of choline acetyltransferase activity", "up regulation of choline acetyltransferase activity", "up-regulation of acetyl-CoA:choline O-acetyltransferase activity", "upregulation of CHOACTase activity", "upregulation of choline acetylase activity", "positive regulation of choline acetyltransferase activity", "positive regulation of acetyl-CoA:choline O-acetyltransferase activity", "up regulation of CHOACTase activity", "up regulation of choline acetylase activity", "up regulation of acetyl-CoA:choline O-acetyltransferase activity", "up-regulation of choline O-acetyltransferase activity", "up regulation of choline O-acetyltransferase activity", "positive regulation of choline acetylase activity", "up-regulation of CHOACTase activity", "up-regulation of choline acetylase activity", "upregulation of acetyl-CoA:choline O-acetyltransferase activity"], "types": ["T044"], "canonical_name": "positive regulation of choline O-acetyltransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of choline O-acetyltransferase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634]"}
{"concept_id": "C3823255", "aliases": [], "types": ["T044"], "canonical_name": "activation of acetyl-CoA:choline O-acetyltransferase activity"}
{"concept_id": "C3823256", "aliases": [], "types": ["T044"], "canonical_name": "activation of CHOACTase activity"}
{"concept_id": "C3823257", "aliases": [], "types": ["T044"], "canonical_name": "activation of choline acetylase activity"}
{"concept_id": "C3823258", "aliases": [], "types": ["T044"], "canonical_name": "activation of choline acetyltransferase activity"}
{"concept_id": "C3823259", "aliases": [], "types": ["T044"], "canonical_name": "activation of choline O-acetyltransferase activity"}
{"concept_id": "C3823260", "aliases": ["up regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway", "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway", "up regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway", "positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signalling pathway", "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signalling pathway", "positive regulation of histidyl-aspartyl phosphorelay involved in H2O2 mediated signaling pathway", "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signaling pathway", "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway", "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway", "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway", "upregulation of two-component signal transduction involved in H2O2 mediated signaling pathway", "up regulation of two-component signal transduction involved in H2O2 mediated signaling pathway", "up-regulation of two-component signal transduction involved in H2O2 mediated signaling pathway", "positive regulation of phosphorelay signal transduction system involved in H2O2 mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signaling pathway", "definition": "Any positive regulation of phosphorelay signal transduction system that is involved in hydrogen peroxide mediated signaling pathway. [GO_REF:0000060, GOC:TermGenie, PMID:18406331]"}
{"concept_id": "C3823261", "aliases": [], "types": ["T044"], "canonical_name": "activation of two-component signal transduction involved in H2O2 mediated signaling pathway"}
{"concept_id": "C3823262", "aliases": ["activation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway"], "types": ["T044"], "canonical_name": "activation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway"}
{"concept_id": "C3823263", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of two-component signal transduction system (phosphorelay) involved in H2O2 mediated signaling pathway"}
{"concept_id": "C3823264", "aliases": ["positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signaling pathway"}
{"concept_id": "C3823265", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of two-component signal transduction involved in H2O2 mediated signaling pathway"}
{"concept_id": "C3823266", "aliases": ["stimulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway"], "types": ["T044"], "canonical_name": "stimulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway"}
{"concept_id": "C3823267", "aliases": ["GTPase activator complex location"], "types": ["T026"], "canonical_name": "GTPase activator complex", "definition": "A protein complex which is capable of GTPase activator activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16449187]"}
{"concept_id": "C3823268", "aliases": [], "types": ["T043"], "canonical_name": "late endosome to lysosome transport", "definition": "The directed movement of substances from late endosome to lysosome. [GO_REF:0000076, GOC:TermGenie, PMID:23949442]"}
{"concept_id": "C3823269", "aliases": [], "types": ["T043"], "canonical_name": "prevacuolar compartment to lysosome transport"}
{"concept_id": "C3823270", "aliases": ["mitochondrial large ribosomal subunit formation"], "types": ["T043"], "canonical_name": "mitochondrial large ribosomal subunit assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit. [GO_REF:0000079, GOC:TermGenie, PMID:24206665]"}
{"concept_id": "C3823271", "aliases": [], "types": ["T043"], "canonical_name": "39S ribosomal subunit, mitochondrial assembly"}
{"concept_id": "C3823272", "aliases": [], "types": ["T043"], "canonical_name": "39S ribosomal subunit, mitochondrial formation"}
{"concept_id": "C3823273", "aliases": ["6-sulfoquinovose(1-) metabolism"], "types": ["T044"], "canonical_name": "6-sulfoquinovose(1-) metabolic process", "definition": "The chemical reactions and pathways involving 6-sulfoquinovose(1-). [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506]"}
{"concept_id": "C3823274", "aliases": ["6-sulfoquinovose(1-) catabolism", "6-sulfoquinovose(1-) breakdown", "6-sulfoquinovose(1-) degradation"], "types": ["T044"], "canonical_name": "6-sulfoquinovose(1-) catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-). [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506]"}
{"concept_id": "C3823275", "aliases": [], "types": ["T043"], "canonical_name": "response to alkane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995]"}
{"concept_id": "C3823276", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to alkane", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995]"}
{"concept_id": "C3823277", "aliases": [], "types": ["T043"], "canonical_name": "response to nonane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739]"}
{"concept_id": "C3823278", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nonane", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739]"}
{"concept_id": "C3823279", "aliases": [], "types": ["T043"], "canonical_name": "response to decane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]"}
{"concept_id": "C3823280", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to decane", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]"}
{"concept_id": "C3823281", "aliases": [], "types": ["T043"], "canonical_name": "response to undecane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]"}
{"concept_id": "C3823282", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to undecane", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]"}
{"concept_id": "C3823283", "aliases": [], "types": ["T043"], "canonical_name": "response to dodecane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]"}
{"concept_id": "C3823284", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to dodecane", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]"}
{"concept_id": "C3823285", "aliases": [], "types": ["T043"], "canonical_name": "response to isooctane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008]"}
{"concept_id": "C3823286", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to isooctane", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus. [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008]"}
{"concept_id": "C3823287", "aliases": ["undecan-2-one metabolism"], "types": ["T044"], "canonical_name": "undecan-2-one metabolic process", "definition": "The chemical reactions and pathways involving undecan-2-one. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559]"}
{"concept_id": "C3823288", "aliases": ["undecan-2-one formation", "undecan-2-one biosynthesis", "undecan-2-one synthesis", "undecan-2-one anabolism"], "types": ["T044"], "canonical_name": "undecan-2-one biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of undecan-2-one. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559]"}
{"concept_id": "C3823289", "aliases": ["pyrroline-5-carboxylate reductase complex location"], "types": ["T026"], "canonical_name": "pyrroline-5-carboxylate reductase complex", "definition": "A protein complex which is capable of pyrroline-5-carboxylate reductase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:2722838]"}
{"concept_id": "C3823290", "aliases": ["glutamate decarboxylase complex location"], "types": ["T026"], "canonical_name": "glutamate decarboxylase complex", "definition": "A protein complex which is capable of glutamate decarboxylase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17384644]"}
{"concept_id": "C3823291", "aliases": ["heterochromatin island formation", "heterochromatin island assembly"], "types": ["T045"], "canonical_name": "siRNA-independent facultative heterochromatin assembly", "definition": "The assembly of facultative heterochromatin to form a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process independent of small interfering RNAs. [GO_REF:0000079, GOC:TermGenie, PMID:22144463, PMID:24210919]"}
{"concept_id": "C3823292", "aliases": ["heterochromatin domain formation", "HOOD assembly", "heterochromatin domain assembly", "HOOD formation"], "types": ["T045"], "canonical_name": "siRNA-dependent facultative heterochromatin assembly", "definition": "The assembly of facultative heterochromatin to form a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a small interfering RNA. [GO_REF:0000079, GOC:TermGenie, PMID:23151475, PMID:24210919]"}
{"concept_id": "C3823293", "aliases": [], "types": ["T045"], "canonical_name": "regulation of snoRNA processing", "definition": "Any process that modulates the frequency, rate or extent of snoRNA processing. [GO_REF:0000058, GOC:TermGenie, PMID:24210919]"}
{"concept_id": "C3823294", "aliases": ["down regulation of snoRNA processing", "down-regulation of snoRNA processing", "downregulation of snoRNA processing"], "types": ["T045"], "canonical_name": "negative regulation of snoRNA processing", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA processing. [GO_REF:0000058, GOC:TermGenie, PMID:24210919]"}
{"concept_id": "C3823295", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of snoRNA processing"}
{"concept_id": "C3823296", "aliases": ["upregulation of snoRNA processing", "up-regulation of snoRNA processing", "up regulation of snoRNA processing"], "types": ["T045"], "canonical_name": "positive regulation of snoRNA processing", "definition": "Any process that activates or increases the frequency, rate or extent of snoRNA processing. [GO_REF:0000058, GOC:TermGenie, PMID:24210919]"}
{"concept_id": "C3823297", "aliases": [], "types": ["T045"], "canonical_name": "activation of snoRNA processing"}
{"concept_id": "C3823298", "aliases": ["regulation of oligonucleate 5'-nucleotidohydrolase activity", "regulation of nucleotide pyrophosphatase/phosphodiesterase I activity", "regulation of orthophosphoric diester phosphohydrolase activity", "regulation of PDE I activity", "regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity"], "types": ["T044"], "canonical_name": "regulation of phosphodiesterase I activity", "definition": "Any process that modulates the frequency, rate or extent of phosphodiesterase I activity. [GO_REF:0000059, GOC:TermGenie, PMID:24559510]"}
{"concept_id": "C3823299", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5'-exonuclease activity"}
{"concept_id": "C3823300", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5'-NPDase activity"}
{"concept_id": "C3823301", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5'-nucleotide phosphodiesterase activity"}
{"concept_id": "C3823302", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5'-PDase activity"}
{"concept_id": "C3823303", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5'-PDE activity"}
{"concept_id": "C3823304", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5'-phosphodiesterase activity"}
{"concept_id": "C3823305", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5'NPDE activity"}
{"concept_id": "C3823306", "aliases": [], "types": ["T044"], "canonical_name": "regulation of alkaline phosphodiesterase activity"}
{"concept_id": "C3823307", "aliases": [], "types": ["T044"], "canonical_name": "regulation of exonuclease I activity"}
{"concept_id": "C3823308", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphodiesterase activity"}
{"concept_id": "C3823309", "aliases": ["up regulation of oligonucleate 5'-nucleotidohydrolase activity", "positive regulation of oligonucleate 5'-nucleotidohydrolase activity", "positive regulation of nucleotide pyrophosphatase/phosphodiesterase I activity", "up regulation of orthophosphoric diester phosphohydrolase activity", "positive regulation of PDE I activity", "up-regulation of nucleotide pyrophosphatase/phosphodiesterase I activity", "up-regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity", "upregulation of PDE I activity", "positive regulation of orthophosphoric diester phosphohydrolase activity", "up regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity", "upregulation of oligonucleate 5'-nucleotidohydrolase activity", "upregulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity", "upregulation of orthophosphoric diester phosphohydrolase activity", "positive regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity", "up regulation of PDE I activity", "up-regulation of phosphodiesterase I activity", "up regulation of nucleotide pyrophosphatase/phosphodiesterase I activity", "upregulation of phosphodiesterase I activity", "upregulation of nucleotide pyrophosphatase/phosphodiesterase I activity", "up-regulation of PDE I activity", "up-regulation of orthophosphoric diester phosphohydrolase activity", "up-regulation of oligonucleate 5'-nucleotidohydrolase activity", "up regulation of phosphodiesterase I activity"], "types": ["T044"], "canonical_name": "positive regulation of phosphodiesterase I activity", "definition": "Any process that activates or increases the frequency, rate or extent of phosphodiesterase I activity. [GO_REF:0000059, GOC:TermGenie, PMID:24559510]"}
{"concept_id": "C3823310", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity"}
{"concept_id": "C3823311", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5'-exonuclease activity"}
{"concept_id": "C3823312", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5'-NPDase activity"}
{"concept_id": "C3823313", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5'-nucleotide phosphodiesterase activity"}
{"concept_id": "C3823314", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5'-PDase activity"}
{"concept_id": "C3823315", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5'-PDE activity"}
{"concept_id": "C3823316", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5'-phosphodiesterase activity"}
{"concept_id": "C3823317", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5'NPDE activity"}
{"concept_id": "C3823318", "aliases": [], "types": ["T044"], "canonical_name": "activation of alkaline phosphodiesterase activity"}
{"concept_id": "C3823319", "aliases": [], "types": ["T044"], "canonical_name": "activation of exonuclease I activity"}
{"concept_id": "C3823320", "aliases": [], "types": ["T044"], "canonical_name": "activation of nucleotide pyrophosphatase/phosphodiesterase I activity"}
{"concept_id": "C3823321", "aliases": [], "types": ["T044"], "canonical_name": "activation of oligonucleate 5'-nucleotidohydrolase activity"}
{"concept_id": "C3823322", "aliases": [], "types": ["T044"], "canonical_name": "activation of orthophosphoric diester phosphohydrolase activity"}
{"concept_id": "C3823323", "aliases": [], "types": ["T044"], "canonical_name": "activation of PDE I activity"}
{"concept_id": "C3823324", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphodiesterase I activity"}
{"concept_id": "C3823325", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 5'-exonuclease activity"}
{"concept_id": "C3823326", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 5'-NPDase activity"}
{"concept_id": "C3823327", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 5'-nucleotide phosphodiesterase activity"}
{"concept_id": "C3823328", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 5'-PDase activity"}
{"concept_id": "C3823329", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 5'-PDE activity"}
{"concept_id": "C3823330", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 5'-phosphodiesterase activity"}
{"concept_id": "C3823331", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 5'NPDE activity"}
{"concept_id": "C3823332", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of alkaline phosphodiesterase activity"}
{"concept_id": "C3823333", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of exonuclease I activity"}
{"concept_id": "C3823334", "aliases": ["up-regulation of 5'-exonuclease activity"], "types": ["T044"], "canonical_name": "up regulation of 5'-exonuclease activity"}
{"concept_id": "C3823335", "aliases": ["up-regulation of 5'-NPDase activity"], "types": ["T044"], "canonical_name": "up regulation of 5'-NPDase activity"}
{"concept_id": "C3823336", "aliases": ["up-regulation of 5'-nucleotide phosphodiesterase activity"], "types": ["T044"], "canonical_name": "up regulation of 5'-nucleotide phosphodiesterase activity"}
{"concept_id": "C3823337", "aliases": ["up-regulation of 5'-PDase activity"], "types": ["T044"], "canonical_name": "up regulation of 5'-PDase activity"}
{"concept_id": "C3823338", "aliases": ["up-regulation of 5'-PDE activity"], "types": ["T044"], "canonical_name": "up regulation of 5'-PDE activity"}
{"concept_id": "C3823339", "aliases": ["up-regulation of 5'-phosphodiesterase activity"], "types": ["T044"], "canonical_name": "up regulation of 5'-phosphodiesterase activity"}
{"concept_id": "C3823340", "aliases": ["up-regulation of 5'NPDE activity"], "types": ["T044"], "canonical_name": "up regulation of 5'NPDE activity"}
{"concept_id": "C3823341", "aliases": ["up-regulation of alkaline phosphodiesterase activity"], "types": ["T044"], "canonical_name": "up regulation of alkaline phosphodiesterase activity"}
{"concept_id": "C3823342", "aliases": ["up-regulation of exonuclease I activity"], "types": ["T044"], "canonical_name": "up regulation of exonuclease I activity"}
{"concept_id": "C3823343", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of 5'-exonuclease activity"}
{"concept_id": "C3823344", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of 5'-NPDase activity"}
{"concept_id": "C3823345", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of 5'-nucleotide phosphodiesterase activity"}
{"concept_id": "C3823346", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of 5'-PDase activity"}
{"concept_id": "C3823347", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of 5'-PDE activity"}
{"concept_id": "C3823348", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of 5'-phosphodiesterase activity"}
{"concept_id": "C3823349", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of 5'NPDE activity"}
{"concept_id": "C3823350", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of alkaline phosphodiesterase activity"}
{"concept_id": "C3823351", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of exonuclease I activity"}
{"concept_id": "C3823352", "aliases": ["regulation of heterochromatin island formation", "regulation of heterochromatin island assembly"], "types": ["T043"], "canonical_name": "regulation of siRNA-independent facultative heterochromatin assembly", "definition": "Any process that modulates the frequency, rate or extent of siRNA-independent facultative heterochromatin assembly. [GO_REF:0000058, GOC:TermGenie, PMID:24210919]"}
{"concept_id": "C3823353", "aliases": ["regulation of heterochromatin domain assembly", "regulation of HOOD assembly", "regulation of heterochromatin domain formation", "regulation of HOOD formation"], "types": ["T043"], "canonical_name": "regulation of siRNA-dependent facultative heterochromatin assembly", "definition": "Any process that modulates the frequency, rate or extent of siRNA-dependent facultative heterochromatin assembly. [GO_REF:0000058, GOC:TermGenie, PMID:24210919]"}
{"concept_id": "C3823354", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic vesicle transport", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle transport. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]"}
{"concept_id": "C3823355", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic vesicle fission"}
{"concept_id": "C3823356", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic vesicle fusion"}
{"concept_id": "C3823357", "aliases": ["down-regulation of synaptic vesicle transport", "down regulation of synaptic vesicle transport", "downregulation of synaptic vesicle transport"], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle transport. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]"}
{"concept_id": "C3823358", "aliases": ["down-regulation of synaptic vesicle fission"], "types": ["T043"], "canonical_name": "down regulation of synaptic vesicle fission"}
{"concept_id": "C3823359", "aliases": ["down-regulation of synaptic vesicle fusion"], "types": ["T043"], "canonical_name": "down regulation of synaptic vesicle fusion"}
{"concept_id": "C3823360", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of synaptic vesicle fission"}
{"concept_id": "C3823361", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of synaptic vesicle fusion"}
{"concept_id": "C3823362", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synaptic vesicle fission"}
{"concept_id": "C3823363", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synaptic vesicle fusion"}
{"concept_id": "C3823364", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synaptic vesicle transport"}
{"concept_id": "C3823365", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle fission"}
{"concept_id": "C3823366", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle fusion"}
{"concept_id": "C3823367", "aliases": ["up-regulation of synaptic vesicle transport", "upregulation of synaptic vesicle transport", "up regulation of synaptic vesicle transport"], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle transport", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle transport. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]"}
{"concept_id": "C3823368", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptic vesicle fission"}
{"concept_id": "C3823369", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptic vesicle fusion"}
{"concept_id": "C3823370", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptic vesicle transport"}
{"concept_id": "C3823371", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle fission"}
{"concept_id": "C3823372", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle fusion"}
{"concept_id": "C3823373", "aliases": ["up-regulation of synaptic vesicle fission"], "types": ["T043"], "canonical_name": "up regulation of synaptic vesicle fission"}
{"concept_id": "C3823374", "aliases": ["up-regulation of synaptic vesicle fusion"], "types": ["T043"], "canonical_name": "up regulation of synaptic vesicle fusion"}
{"concept_id": "C3823375", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of synaptic vesicle fission"}
{"concept_id": "C3823376", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of synaptic vesicle fusion"}
{"concept_id": "C3823377", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell cycle G1/S phase transition", "definition": "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3823378", "aliases": ["down-regulation of cell cycle G1/S phase transition", "down regulation of cell cycle G1/S phase transition", "downregulation of cell cycle G1/S phase transition"], "types": ["T043"], "canonical_name": "negative regulation of cell cycle G1/S phase transition", "definition": "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3823379", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell cycle G1/S phase transition"}
{"concept_id": "C3823380", "aliases": ["up-regulation of cell cycle G1/S phase transition", "up regulation of cell cycle G1/S phase transition", "upregulation of cell cycle G1/S phase transition"], "types": ["T043"], "canonical_name": "positive regulation of cell cycle G1/S phase transition", "definition": "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3823381", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell cycle G1/S phase transition"}
{"concept_id": "C3823382", "aliases": [], "types": ["T043"], "canonical_name": "regulation of skeletal muscle fiber differentiation", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]"}
{"concept_id": "C3823383", "aliases": ["down-regulation of skeletal muscle fiber differentiation", "downregulation of skeletal muscle fiber differentiation", "down regulation of skeletal muscle fiber differentiation"], "types": ["T043"], "canonical_name": "negative regulation of skeletal muscle fiber differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]"}
{"concept_id": "C3823384", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of skeletal muscle fiber differentiation"}
{"concept_id": "C3823385", "aliases": ["upregulation of skeletal muscle fiber differentiation", "up-regulation of skeletal muscle fiber differentiation", "up regulation of skeletal muscle fiber differentiation"], "types": ["T043"], "canonical_name": "positive regulation of skeletal muscle fiber differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]"}
{"concept_id": "C3823386", "aliases": [], "types": ["T043"], "canonical_name": "activation of skeletal muscle fiber differentiation"}
{"concept_id": "C3823387", "aliases": ["regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry"], "types": ["T043"], "canonical_name": "regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "definition": "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580]"}
{"concept_id": "C3823388", "aliases": ["down-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "negative regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "downregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "down-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "downregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "down regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "negative regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "down-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "downregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "down regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "down regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry"], "types": ["T043"], "canonical_name": "negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580]"}
{"concept_id": "C3823389", "aliases": ["inhibition of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "inhibition of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry"], "types": ["T043"], "canonical_name": "inhibition of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry"}
{"concept_id": "C3823390", "aliases": ["up-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "upregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "positive regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "up-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "positive regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "up-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "upregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "up regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "up regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "up regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination", "upregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry"], "types": ["T043"], "canonical_name": "positive regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry", "definition": "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580]"}
{"concept_id": "C3823391", "aliases": ["activation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry", "activation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination"], "types": ["T043"], "canonical_name": "activation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry"}
{"concept_id": "C3823392", "aliases": [], "types": ["T043"], "canonical_name": "N,N'-diacetylchitobiose import", "definition": "The directed movement of N,N'-diacetylchitobiose into a cell or organelle. [GO_REF:0000073, GOC:am, GOC:TermGenie, PMID:9405618]"}
{"concept_id": "C3823393", "aliases": ["regulation of protein localisation to microtubule"], "types": ["T039"], "canonical_name": "regulation of protein localization to microtubule", "definition": "Any process that modulates the frequency, rate or extent of protein localization to microtubule. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]"}
{"concept_id": "C3823394", "aliases": ["negative regulation of protein localisation to microtubule", "downregulation of protein localisation to microtubule", "down-regulation of protein localisation to microtubule", "down regulation of protein localisation to microtubule", "down-regulation of protein localization to microtubule", "down regulation of protein localization to microtubule", "downregulation of protein localization to microtubule"], "types": ["T039"], "canonical_name": "negative regulation of protein localization to microtubule", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]"}
{"concept_id": "C3823395", "aliases": ["inhibition of protein localization to microtubule"], "types": ["T039"], "canonical_name": "inhibition of protein localisation to microtubule"}
{"concept_id": "C3823396", "aliases": ["ethyl ethanoate metabolic process", "ethyl acetate metabolism"], "types": ["T040"], "canonical_name": "ethyl acetate metabolic process", "definition": "The chemical reactions and pathways involving ethyl acetate. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]"}
{"concept_id": "C3823397", "aliases": ["ethyl acetate synthesis", "ethyl acetate anabolism", "ethyl ethanoate biosynthetic process", "ethyl acetate formation", "ethyl acetate biosynthesis"], "types": ["T044"], "canonical_name": "ethyl acetate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ethyl acetate. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]"}
{"concept_id": "C3823398", "aliases": ["1-undecene metabolism"], "types": ["T043"], "canonical_name": "1-undecene metabolic process", "definition": "The chemical reactions and pathways involving 1-undecene. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]"}
{"concept_id": "C3823399", "aliases": ["1-undecene formation", "1-undecene biosynthesis", "1-undecene synthesis", "1-undecene anabolism"], "types": ["T043"], "canonical_name": "1-undecene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 1-undecene. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]"}
{"concept_id": "C3823400", "aliases": [], "types": ["T043"], "canonical_name": "regulation of late endosome to lysosome transport", "definition": "Any process that modulates the frequency, rate or extent of late endosome to lysosome transport. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442]"}
{"concept_id": "C3823401", "aliases": [], "types": ["T043"], "canonical_name": "regulation of prevacuolar compartment to lysosome transport"}
{"concept_id": "C3823402", "aliases": ["down regulation of late endosome to lysosome transport", "down-regulation of late endosome to lysosome transport", "downregulation of late endosome to lysosome transport"], "types": ["T043"], "canonical_name": "negative regulation of late endosome to lysosome transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of late endosome to lysosome transport. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442]"}
{"concept_id": "C3823403", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of late endosome to lysosome transport"}
{"concept_id": "C3823404", "aliases": ["up regulation of late endosome to lysosome transport", "up-regulation of late endosome to lysosome transport", "upregulation of late endosome to lysosome transport"], "types": ["T043"], "canonical_name": "positive regulation of late endosome to lysosome transport", "definition": "Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442]"}
{"concept_id": "C3823405", "aliases": [], "types": ["T043"], "canonical_name": "activation of late endosome to lysosome transport"}
{"concept_id": "C3823406", "aliases": ["proline import into cell"], "types": ["T043"], "canonical_name": "proline import across plasma membrane", "definition": "The directed movement of proline from outside of a cell into the cytoplasmic compartment. [GO_REF:0000075, GOC:TermGenie, PMID:24344203]"}
{"concept_id": "C3823407", "aliases": ["regulation of L-arginine import into cell"], "types": ["T043"], "canonical_name": "regulation of L-arginine import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of L-arginine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:14718525]"}
{"concept_id": "C3823408", "aliases": ["down regulation of L-arginine import into cell", "downregulation of L-arginine import into cell", "negative regulation of L-arginine import into cell"], "types": ["T043"], "canonical_name": "negative regulation of L-arginine import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-arginine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:14718525]"}
{"concept_id": "C3823409", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of L-arginine import into cell"}
{"concept_id": "C3823410", "aliases": ["up-regulation of L-arginine import into cell", "positive regulation of L-arginine import into cell", "activation of L-arginine uptake", "up-regulation of L-arginine uptake", "up regulation of L-arginine import", "up-regulation of L-arginine import", "upregulation of L-arginine import into cell", "upregulation of L-arginine import", "up regulation of L-arginine uptake", "positive regulation of L-arginine uptake", "upregulation of L-arginine uptake"], "types": ["T043"], "canonical_name": "positive regulation of L-arginine import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of L-arginine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:14718525]"}
{"concept_id": "C3823411", "aliases": [], "types": ["T043"], "canonical_name": "activation of L-arginine import into cell"}
{"concept_id": "C3823412", "aliases": ["regulation of spinal cord dorsal interneuron differentiation"], "types": ["T043"], "canonical_name": "regulation of spinal cord association neuron differentiation", "definition": "Any process that modulates the frequency, rate or extent of spinal cord association neuron differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]"}
{"concept_id": "C3823413", "aliases": ["negative regulation of spinal cord dorsal interneuron differentiation", "down regulation of spinal cord dorsal interneuron differentiation", "down-regulation of spinal cord association neuron differentiation", "downregulation of spinal cord association neuron differentiation", "down regulation of spinal cord association neuron differentiation", "down-regulation of spinal cord dorsal interneuron differentiation", "downregulation of spinal cord dorsal interneuron differentiation"], "types": ["T043"], "canonical_name": "negative regulation of spinal cord association neuron differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of spinal cord association neuron differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]"}
{"concept_id": "C3823414", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of spinal cord association neuron differentiation"}
{"concept_id": "C3823415", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of spinal cord dorsal interneuron differentiation"}
{"concept_id": "C3823416", "aliases": ["up regulation of spinal cord dorsal interneuron differentiation", "upregulation of spinal cord association neuron differentiation", "up regulation of spinal cord association neuron differentiation", "upregulation of spinal cord dorsal interneuron differentiation", "up-regulation of spinal cord association neuron differentiation", "up-regulation of spinal cord dorsal interneuron differentiation", "positive regulation of spinal cord dorsal interneuron differentiation"], "types": ["T043"], "canonical_name": "positive regulation of spinal cord association neuron differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of spinal cord association neuron differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]"}
{"concept_id": "C3823417", "aliases": [], "types": ["T043"], "canonical_name": "activation of spinal cord association neuron differentiation"}
{"concept_id": "C3823418", "aliases": [], "types": ["T043"], "canonical_name": "activation of spinal cord dorsal interneuron differentiation"}
{"concept_id": "C3823419", "aliases": ["down-regulation of cell proliferation in dorsal spinal cord", "downregulation of cell proliferation in dorsal spinal cord", "down regulation of cell proliferation in dorsal spinal cord"], "types": ["T038"], "canonical_name": "negative regulation of cell proliferation in dorsal spinal cord", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in dorsal spinal cord. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]"}
{"concept_id": "C3823420", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of cell proliferation in dorsal spinal cord"}
{"concept_id": "C3823421", "aliases": ["upregulation of cell proliferation in dorsal spinal cord", "up regulation of cell proliferation in dorsal spinal cord", "up-regulation of cell proliferation in dorsal spinal cord"], "types": ["T038"], "canonical_name": "positive regulation of cell proliferation in dorsal spinal cord", "definition": "Any process that activates or increases the frequency, rate or extent of cell proliferation in dorsal spinal cord. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]"}
{"concept_id": "C3823422", "aliases": [], "types": ["T038"], "canonical_name": "activation of cell proliferation in dorsal spinal cord"}
{"concept_id": "C3823423", "aliases": ["regulation of proline import into cell"], "types": ["T044"], "canonical_name": "regulation of proline import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of proline import into cell. [GO_REF:0000058, GOC:TermGenie, PMID:24344203]"}
{"concept_id": "C3823424", "aliases": ["down-regulation of proline import into cell", "negative regulation of proline import into cell", "downregulation of proline import into cell", "down regulation of proline import into cell"], "types": ["T044"], "canonical_name": "negative regulation of proline import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of proline import into cell. [GO_REF:0000058, GOC:TermGenie, PMID:24344203]"}
{"concept_id": "C3823425", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of proline import into cell"}
{"concept_id": "C3823426", "aliases": ["positive regulation of proline import into cell", "upregulation of proline import into cell", "up regulation of proline import into cell", "up-regulation of proline import into cell"], "types": ["T044"], "canonical_name": "positive regulation of proline import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of proline import into cell. [GO_REF:0000058, GOC:TermGenie, PMID:24344203]"}
{"concept_id": "C3823427", "aliases": [], "types": ["T044"], "canonical_name": "activation of proline import into cell"}
{"concept_id": "C3823429", "aliases": ["regulation of nuclear migration, microtubule-mediated", "regulation of microtubule-dependent nuclear positioning", "regulation of microtubule-dependent nucleus positioning", "regulation of microtubule cytoskeleton-dependent nuclear positioning", "regulation of transport of nucleus by microtubules", "regulation of microtubule cytoskeleton-dependent nucleus positioning", "regulation of transport of nucleus, microtubule-mediated", "regulation of microtubule-mediated nuclear migration"], "types": ["T043"], "canonical_name": "regulation of nuclear migration along microtubule", "definition": "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule. [GO_REF:0000058, GOC:TermGenie, PMID:23087209]"}
{"concept_id": "C3823430", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nuclear movement, microtubule-mediated"}
{"concept_id": "C3823431", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nucleus migration"}
{"concept_id": "C3823432", "aliases": ["down-regulation of microtubule-mediated nuclear migration", "down regulation of transport of nucleus, microtubule-mediated", "negative regulation of microtubule cytoskeleton-dependent nuclear positioning", "down regulation of microtubule-mediated nuclear migration", "downregulation of microtubule cytoskeleton-dependent nuclear positioning", "down-regulation of microtubule cytoskeleton-dependent nuclear positioning", "down-regulation of nuclear migration, microtubule-mediated", "negative regulation of microtubule-mediated nuclear migration", "downregulation of microtubule cytoskeleton-dependent nucleus positioning", "down-regulation of nuclear migration along microtubule", "down regulation of microtubule cytoskeleton-dependent nuclear positioning", "down regulation of nuclear migration, microtubule-mediated", "down-regulation of transport of nucleus, microtubule-mediated", "negative regulation of microtubule cytoskeleton-dependent nucleus positioning", "downregulation of microtubule-dependent nucleus positioning", "down-regulation of microtubule-dependent nuclear positioning", "down regulation of transport of nucleus by microtubules", "down regulation of microtubule-dependent nucleus positioning", "negative regulation of microtubule-dependent nucleus positioning", "downregulation of nuclear migration along microtubule", "downregulation of microtubule-dependent nuclear positioning", "downregulation of transport of nucleus by microtubules", "downregulation of microtubule-mediated nuclear migration", "down-regulation of microtubule cytoskeleton-dependent nucleus positioning", "downregulation of transport of nucleus, microtubule-mediated", "down regulation of microtubule cytoskeleton-dependent nucleus positioning", "downregulation of nuclear migration, microtubule-mediated", "negative regulation of transport of nucleus, microtubule-mediated", "negative regulation of nuclear migration, microtubule-mediated", "negative regulation of transport of nucleus by microtubules", "down regulation of microtubule-dependent nuclear positioning", "negative regulation of microtubule-dependent nuclear positioning", "down-regulation of microtubule-dependent nucleus positioning", "down regulation of nuclear migration along microtubule", "down-regulation of transport of nucleus by microtubules"], "types": ["T043"], "canonical_name": "negative regulation of nuclear migration along microtubule", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule. [GO_REF:0000058, GOC:TermGenie, PMID:23087209]"}
{"concept_id": "C3823433", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microtubule cytoskeleton-dependent nuclear positioning"}
{"concept_id": "C3823434", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microtubule cytoskeleton-dependent nucleus positioning"}
{"concept_id": "C3823435", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microtubule-dependent nuclear positioning"}
{"concept_id": "C3823436", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microtubule-dependent nucleus positioning"}
{"concept_id": "C3823437", "aliases": ["inhibition of nuclear migration, microtubule-mediated"], "types": ["T043"], "canonical_name": "inhibition of microtubule-mediated nuclear migration"}
{"concept_id": "C3823438", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nuclear migration along microtubule"}
{"concept_id": "C3823439", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of transport of nucleus by microtubules"}
{"concept_id": "C3823440", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of transport of nucleus, microtubule-mediated"}
{"concept_id": "C3823441", "aliases": ["positive regulation of transport of nucleus by microtubules", "up-regulation of transport of nucleus, microtubule-mediated", "upregulation of transport of nucleus, microtubule-mediated", "upregulation of nuclear migration, microtubule-mediated", "upregulation of microtubule-dependent nucleus positioning", "upregulation of microtubule-mediated nuclear migration", "positive regulation of microtubule cytoskeleton-dependent nuclear positioning", "positive regulation of microtubule-dependent nucleus positioning", "positive regulation of microtubule-dependent nuclear positioning", "up regulation of microtubule-dependent nuclear positioning", "up regulation of nuclear migration, microtubule-mediated", "upregulation of transport of nucleus by microtubules", "up regulation of transport of nucleus, microtubule-mediated", "positive regulation of microtubule cytoskeleton-dependent nucleus positioning", "up regulation of microtubule cytoskeleton-dependent nucleus positioning", "positive regulation of transport of nucleus, microtubule-mediated", "up-regulation of microtubule cytoskeleton-dependent nucleus positioning", "up regulation of transport of nucleus by microtubules", "up regulation of nuclear migration along microtubule", "up-regulation of microtubule-dependent nuclear positioning", "up regulation of microtubule-dependent nucleus positioning", "upregulation of microtubule-dependent nuclear positioning", "positive regulation of microtubule-mediated nuclear migration", "up-regulation of microtubule-mediated nuclear migration", "up-regulation of nuclear migration along microtubule", "up-regulation of microtubule-dependent nucleus positioning", "upregulation of microtubule cytoskeleton-dependent nucleus positioning", "upregulation of nuclear migration along microtubule", "positive regulation of nuclear migration, microtubule-mediated", "up regulation of microtubule-mediated nuclear migration", "up-regulation of nuclear migration, microtubule-mediated", "upregulation of microtubule cytoskeleton-dependent nuclear positioning", "up-regulation of microtubule cytoskeleton-dependent nuclear positioning", "up-regulation of transport of nucleus by microtubules", "up regulation of microtubule cytoskeleton-dependent nuclear positioning"], "types": ["T043"], "canonical_name": "positive regulation of nuclear migration along microtubule", "definition": "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule. [GO_REF:0000058, GOC:TermGenie, PMID:23087209]"}
{"concept_id": "C3823442", "aliases": [], "types": ["T043"], "canonical_name": "activation of microtubule cytoskeleton-dependent nuclear positioning"}
{"concept_id": "C3823443", "aliases": [], "types": ["T043"], "canonical_name": "activation of microtubule cytoskeleton-dependent nucleus positioning"}
{"concept_id": "C3823444", "aliases": [], "types": ["T043"], "canonical_name": "activation of microtubule-dependent nuclear positioning"}
{"concept_id": "C3823445", "aliases": [], "types": ["T043"], "canonical_name": "activation of microtubule-dependent nucleus positioning"}
{"concept_id": "C3823446", "aliases": ["activation of nuclear migration, microtubule-mediated"], "types": ["T043"], "canonical_name": "activation of microtubule-mediated nuclear migration"}
{"concept_id": "C3823447", "aliases": [], "types": ["T043"], "canonical_name": "activation of nuclear migration along microtubule"}
{"concept_id": "C3823448", "aliases": [], "types": ["T043"], "canonical_name": "activation of transport of nucleus by microtubules"}
{"concept_id": "C3823449", "aliases": [], "types": ["T043"], "canonical_name": "activation of transport of nucleus, microtubule-mediated"}
{"concept_id": "C3823450", "aliases": ["regulation of netrin-activated signalling pathway", "regulation of netrin-mediated signaling pathway", "regulation of netrin signaling pathway", "regulation of netrin-activated signal transduction pathway"], "types": ["T044"], "canonical_name": "regulation of netrin-activated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of netrin-activated signaling pathway. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945]"}
{"concept_id": "C3823451", "aliases": ["down regulation of netrin-mediated signaling pathway", "downregulation of netrin-activated signaling pathway", "negative regulation of netrin signaling pathway", "negative regulation of netrin-mediated signaling pathway", "down-regulation of netrin-activated signalling pathway", "down-regulation of netrin-activated signaling pathway", "downregulation of netrin-activated signalling pathway", "negative regulation of netrin-activated signal transduction pathway", "down regulation of netrin-activated signalling pathway", "downregulation of netrin signaling pathway", "down regulation of netrin signaling pathway", "down-regulation of netrin signaling pathway", "downregulation of netrin-mediated signaling pathway", "negative regulation of netrin-activated signalling pathway", "downregulation of netrin-activated signal transduction pathway", "down-regulation of netrin-mediated signaling pathway", "down-regulation of netrin-activated signal transduction pathway", "down regulation of netrin-activated signal transduction pathway", "down regulation of netrin-activated signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of netrin-activated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of netrin-activated signaling pathway. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945]"}
{"concept_id": "C3823452", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of netrin signaling pathway"}
{"concept_id": "C3823453", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of netrin-activated signal transduction pathway"}
{"concept_id": "C3823454", "aliases": ["inhibition of netrin-activated signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of netrin-activated signaling pathway"}
{"concept_id": "C3823455", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of netrin-mediated signaling pathway"}
{"concept_id": "C3823456", "aliases": ["positive regulation of netrin signaling pathway", "up regulation of netrin-activated signal transduction pathway", "positive regulation of netrin-activated signal transduction pathway", "up regulation of netrin-activated signaling pathway", "up-regulation of netrin-activated signal transduction pathway", "upregulation of netrin-activated signalling pathway", "up-regulation of netrin-activated signaling pathway", "upregulation of netrin signaling pathway", "upregulation of netrin-activated signal transduction pathway", "up regulation of netrin-mediated signaling pathway", "positive regulation of netrin-mediated signaling pathway", "up-regulation of netrin-mediated signaling pathway", "up regulation of netrin signaling pathway", "up regulation of netrin-activated signalling pathway", "positive regulation of netrin-activated signalling pathway", "upregulation of netrin-activated signaling pathway", "up-regulation of netrin-activated signalling pathway", "upregulation of netrin-mediated signaling pathway", "up-regulation of netrin signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of netrin-activated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of netrin-activated signaling pathway. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945]"}
{"concept_id": "C3823457", "aliases": [], "types": ["T044"], "canonical_name": "activation of netrin signaling pathway"}
{"concept_id": "C3823458", "aliases": [], "types": ["T044"], "canonical_name": "activation of netrin-activated signal transduction pathway"}
{"concept_id": "C3823459", "aliases": ["activation of netrin-activated signalling pathway"], "types": ["T044"], "canonical_name": "activation of netrin-activated signaling pathway"}
{"concept_id": "C3823460", "aliases": [], "types": ["T044"], "canonical_name": "activation of netrin-mediated signaling pathway"}
{"concept_id": "C3823461", "aliases": ["upregulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway", "up regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway", "positive regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway", "upregulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway", "up-regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway", "up regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway", "up-regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway", "definition": "A negative regulation of canonical Wnt signaling pathway that results in positive regulation of spinal cord association neuron differentiation. [GO_REF:0000063, GOC:mr, GOC:TermGenie, PMID:11262869]"}
{"concept_id": "C3823462", "aliases": [], "types": ["T043"], "canonical_name": "activation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway"}
{"concept_id": "C3823463", "aliases": [], "types": ["T043"], "canonical_name": "activation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway"}
{"concept_id": "C3823464", "aliases": ["downregulation of spindle elongation during mitosis", "down regulation of spindle elongation during mitosis", "down regulation of mitotic spindle elongation", "down-regulation of mitotic spindle elongation", "down-regulation of spindle elongation during mitosis", "downregulation of mitotic spindle elongation", "negative regulation of spindle elongation during mitosis"], "types": ["T043"], "canonical_name": "negative regulation of mitotic spindle elongation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation. [GO_REF:0000058, GOC:TermGenie, PMID:23087209]"}
{"concept_id": "C3823465", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic spindle elongation"}
{"concept_id": "C3823466", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of spindle elongation during mitosis"}
{"concept_id": "C3823467", "aliases": ["upregulation of mitotic spindle elongation", "upregulation of spindle elongation during mitosis", "up-regulation of spindle elongation during mitosis", "up-regulation of mitotic spindle elongation", "up regulation of spindle elongation during mitosis", "up regulation of mitotic spindle elongation", "positive regulation of spindle elongation during mitosis"], "types": ["T043"], "canonical_name": "positive regulation of mitotic spindle elongation", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation. [GO_REF:0000058, GOC:TermGenie, PMID:23087209]"}
{"concept_id": "C3823468", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic spindle elongation"}
{"concept_id": "C3823469", "aliases": [], "types": ["T043"], "canonical_name": "activation of spindle elongation during mitosis"}
{"concept_id": "C3823470", "aliases": [], "types": ["T044"], "canonical_name": "regulation of neuronal signal transduction", "definition": "Any process that modulates the frequency, rate or extent of neuronal signal transduction. [GO_REF:0000058, GOC:sjp, GOC:TermGenie]"}
{"concept_id": "C3823471", "aliases": ["down regulation of neuronal signal transduction", "downregulation of neuronal signal transduction", "down-regulation of neuronal signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of neuronal signal transduction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal signal transduction. [GO_REF:0000058, GOC:sjp, GOC:TermGenie]"}
{"concept_id": "C3823472", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of neuronal signal transduction"}
{"concept_id": "C3823473", "aliases": ["upregulation of neuronal signal transduction", "up regulation of neuronal signal transduction", "up-regulation of neuronal signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of neuronal signal transduction", "definition": "Any process that activates or increases the frequency, rate or extent of neuronal signal transduction. [GO_REF:0000058, GOC:sjp, GOC:TermGenie]"}
{"concept_id": "C3823474", "aliases": [], "types": ["T044"], "canonical_name": "activation of neuronal signal transduction"}
{"concept_id": "C3823475", "aliases": ["microtubule cytoskeleton organisation involved in mitosis", "microtubule dynamics involved in mitosis"], "types": ["T043"], "canonical_name": "microtubule cytoskeleton organization involved in mitosis", "definition": "Any microtubule cytoskeleton organization that is involved in mitosis. [GO_REF:0000060, GOC:TermGenie, PMID:18799626]"}
{"concept_id": "C3823476", "aliases": [], "types": ["T043"], "canonical_name": "microtubule cytoskeleton organization and biogenesis involved in mitosis"}
{"concept_id": "C3823477", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nuclear migration during mitotic telophase", "definition": "Any process that modulates the frequency, rate or extent of nuclear migration during mitotic telophase. [GO_REF:0000058, GOC:TermGenie, PMID:23087209]"}
{"concept_id": "C3823478", "aliases": ["downregulation of nuclear migration during mitotic telophase", "down regulation of nuclear migration during mitotic telophase", "down-regulation of nuclear migration during mitotic telophase"], "types": ["T043"], "canonical_name": "negative regulation of nuclear migration during mitotic telophase", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration during mitotic telophase. [GO_REF:0000058, GOC:TermGenie, PMID:23087209]"}
{"concept_id": "C3823479", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nuclear migration during mitotic telophase"}
{"concept_id": "C3823480", "aliases": ["upregulation of nuclear migration during mitotic telophase", "up regulation of nuclear migration during mitotic telophase", "up-regulation of nuclear migration during mitotic telophase"], "types": ["T043"], "canonical_name": "positive regulation of nuclear migration during mitotic telophase", "definition": "Any process that activates or increases the frequency, rate or extent of nuclear migration during mitotic telophase. [GO_REF:0000058, GOC:TermGenie, PMID:23087209]"}
{"concept_id": "C3823481", "aliases": [], "types": ["T043"], "canonical_name": "activation of nuclear migration during mitotic telophase"}
{"concept_id": "C3823482", "aliases": ["regulation of nonmotile primary cilium assembly", "regulation of immotile primary cilium assembly", "regulation of sensory cilium assembly"], "types": ["T043"], "canonical_name": "regulation of nonmotile primary cilia assembly"}
{"concept_id": "C3823484", "aliases": [], "types": ["T038"], "canonical_name": "regulation of sensory cilium biogenesis"}
{"concept_id": "C3823485", "aliases": ["downregulation of immotile primary cilium assembly", "downregulation of nonmotile primary cilia assembly", "down-regulation of immotile primary cilium assembly", "down-regulation of sensory cilium assembly", "down-regulation of nonmotile primary cilium assembly", "negative regulation of sensory cilium assembly", "downregulation of sensory cilium assembly", "negative regulation of nonmotile primary cilium assembly", "down regulation of nonmotile primary cilia assembly", "down-regulation of nonmotile primary cilia assembly", "downregulation of nonmotile primary cilium assembly", "negative regulation of immotile primary cilium assembly", "down regulation of nonmotile primary cilium assembly", "down regulation of sensory cilium assembly", "down regulation of immotile primary cilium assembly"], "types": ["T043"], "canonical_name": "negative regulation of nonmotile primary cilia assembly"}
{"concept_id": "C3823487", "aliases": ["down-regulation of sensory cilium biogenesis"], "types": ["T043"], "canonical_name": "down regulation of sensory cilium biogenesis"}
{"concept_id": "C3823489", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of sensory cilium biogenesis"}
{"concept_id": "C3823490", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of immotile primary cilium assembly"}
{"concept_id": "C3823491", "aliases": ["inhibition of nonmotile primary cilium assembly"], "types": ["T043"], "canonical_name": "inhibition of nonmotile primary cilia assembly"}
{"concept_id": "C3823492", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sensory cilium assembly"}
{"concept_id": "C3823493", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sensory cilium biogenesis"}
{"concept_id": "C3823495", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of sensory cilium biogenesis"}
{"concept_id": "C3823496", "aliases": ["up-regulation of immotile primary cilium assembly", "upregulation of sensory cilium assembly", "up regulation of sensory cilium assembly", "upregulation of nonmotile primary cilium assembly", "up regulation of nonmotile primary cilia assembly", "positive regulation of immotile primary cilium assembly", "up-regulation of nonmotile primary cilia assembly", "up-regulation of nonmotile primary cilium assembly", "up regulation of nonmotile primary cilium assembly", "positive regulation of nonmotile primary cilium assembly", "up-regulation of sensory cilium assembly", "upregulation of immotile primary cilium assembly", "up regulation of immotile primary cilium assembly", "upregulation of nonmotile primary cilia assembly", "positive regulation of sensory cilium assembly"], "types": ["T043"], "canonical_name": "positive regulation of nonmotile primary cilia assembly"}
{"concept_id": "C3823497", "aliases": [], "types": ["T043"], "canonical_name": "activation of immotile primary cilium assembly"}
{"concept_id": "C3823498", "aliases": ["activation of nonmotile primary cilium assembly"], "types": ["T043"], "canonical_name": "activation of nonmotile primary cilia assembly"}
{"concept_id": "C3823499", "aliases": [], "types": ["T043"], "canonical_name": "activation of sensory cilium assembly"}
{"concept_id": "C3823500", "aliases": [], "types": ["T043"], "canonical_name": "activation of sensory cilium biogenesis"}
{"concept_id": "C3823502", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of sensory cilium biogenesis"}
{"concept_id": "C3823504", "aliases": ["up-regulation of sensory cilium biogenesis"], "types": ["T043"], "canonical_name": "up regulation of sensory cilium biogenesis"}
{"concept_id": "C3823506", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of sensory cilium biogenesis"}
{"concept_id": "C3823507", "aliases": ["propionyl-CoA metabolism"], "types": ["T044"], "canonical_name": "propionyl-CoA metabolic process", "definition": "The chemical reactions and pathways involving propionyl-CoA. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053]"}
{"concept_id": "C3823508", "aliases": ["propionyl-CoA breakdown", "propionyl-CoA degradation", "propionyl-CoA catabolism"], "types": ["T044"], "canonical_name": "propionyl-CoA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of propionyl-CoA. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053]"}
{"concept_id": "C3823509", "aliases": ["propionyl-CoA biosynthesis", "propionyl-CoA formation", "propionyl-CoA anabolism", "propionyl-CoA synthesis"], "types": ["T044"], "canonical_name": "propionyl-CoA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of propionyl-CoA. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053]"}
{"concept_id": "C3823513", "aliases": ["regulation of embryonic eye development"], "types": ["T040"], "canonical_name": "regulation of embryonic camera-type eye development", "definition": "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823514", "aliases": ["down regulation of embryonic camera-type eye development", "downregulation of embryonic eye development", "downregulation of embryonic camera-type eye development", "down-regulation of embryonic camera-type eye development", "negative regulation of embryonic eye development", "down-regulation of embryonic eye development", "down regulation of embryonic eye development"], "types": ["T039"], "canonical_name": "negative regulation of embryonic camera-type eye development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823515", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of embryonic camera-type eye development"}
{"concept_id": "C3823516", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of embryonic eye development"}
{"concept_id": "C3823517", "aliases": ["up-regulation of embryonic camera-type eye development", "positive regulation of embryonic eye development", "upregulation of embryonic eye development", "up regulation of embryonic camera-type eye development", "up-regulation of embryonic eye development", "upregulation of embryonic camera-type eye development", "up regulation of embryonic eye development"], "types": ["T039"], "canonical_name": "positive regulation of embryonic camera-type eye development", "definition": "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823518", "aliases": [], "types": ["T039"], "canonical_name": "activation of embryonic camera-type eye development"}
{"concept_id": "C3823519", "aliases": [], "types": ["T039"], "canonical_name": "activation of embryonic eye development"}
{"concept_id": "C3823520", "aliases": ["regulation of retina development in camera-style eye"], "types": ["T038"], "canonical_name": "regulation of retina development in camera-type eye", "definition": "Any process that modulates the frequency, rate or extent of retina development in camera-type eye. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823521", "aliases": [], "types": ["T038"], "canonical_name": "regulation of retinal development"}
{"concept_id": "C3823522", "aliases": ["negative regulation of retina development in camera-style eye", "down regulation of retina development in camera-style eye", "down-regulation of retina development in camera-type eye", "down-regulation of retina development in camera-style eye", "down regulation of retina development in camera-type eye", "downregulation of retina development in camera-style eye", "downregulation of retina development in camera-type eye"], "types": ["T039"], "canonical_name": "negative regulation of retina development in camera-type eye", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823523", "aliases": ["down-regulation of retinal development"], "types": ["T039"], "canonical_name": "down regulation of retinal development"}
{"concept_id": "C3823524", "aliases": [], "types": ["T039"], "canonical_name": "downregulation of retinal development"}
{"concept_id": "C3823525", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of retina development in camera-style eye"}
{"concept_id": "C3823526", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of retina development in camera-type eye"}
{"concept_id": "C3823527", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of retinal development"}
{"concept_id": "C3823528", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of retinal development"}
{"concept_id": "C3823529", "aliases": ["up regulation of retina development in camera-style eye", "up regulation of retina development in camera-type eye", "positive regulation of retina development in camera-style eye", "upregulation of retina development in camera-style eye", "up-regulation of retina development in camera-type eye", "upregulation of retina development in camera-type eye", "up-regulation of retina development in camera-style eye"], "types": ["T039"], "canonical_name": "positive regulation of retina development in camera-type eye", "definition": "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823530", "aliases": [], "types": ["T039"], "canonical_name": "activation of retina development in camera-style eye"}
{"concept_id": "C3823531", "aliases": [], "types": ["T039"], "canonical_name": "activation of retina development in camera-type eye"}
{"concept_id": "C3823532", "aliases": [], "types": ["T039"], "canonical_name": "activation of retinal development"}
{"concept_id": "C3823533", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of retinal development"}
{"concept_id": "C3823534", "aliases": ["up-regulation of retinal development"], "types": ["T039"], "canonical_name": "up regulation of retinal development"}
{"concept_id": "C3823535", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of retinal development"}
{"concept_id": "C3823536", "aliases": ["regulation of amacrine neuron differentiation"], "types": ["T043"], "canonical_name": "regulation of amacrine cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of amacrine cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823537", "aliases": ["negative regulation of amacrine neuron differentiation", "down regulation of amacrine cell differentiation", "downregulation of amacrine neuron differentiation", "downregulation of amacrine cell differentiation", "down-regulation of amacrine cell differentiation", "down regulation of amacrine neuron differentiation", "down-regulation of amacrine neuron differentiation"], "types": ["T043"], "canonical_name": "negative regulation of amacrine cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823538", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of amacrine cell differentiation"}
{"concept_id": "C3823539", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of amacrine neuron differentiation"}
{"concept_id": "C3823540", "aliases": ["up regulation of amacrine cell differentiation", "upregulation of amacrine neuron differentiation", "up regulation of amacrine neuron differentiation", "up-regulation of amacrine neuron differentiation", "positive regulation of amacrine neuron differentiation", "upregulation of amacrine cell differentiation", "up-regulation of amacrine cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of amacrine cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823541", "aliases": [], "types": ["T043"], "canonical_name": "activation of amacrine cell differentiation"}
{"concept_id": "C3823542", "aliases": [], "types": ["T043"], "canonical_name": "activation of amacrine neuron differentiation"}
{"concept_id": "C3823543", "aliases": ["regulation of horizontal cell localisation", "regulation of retinal horizontal cell positioning", "regulation of horizontal cell positioning", "regulation of laminar positioning of retinal horizontal cell"], "types": ["T039"], "canonical_name": "regulation of horizontal cell localization", "definition": "Any process that modulates the frequency, rate or extent of horizontal cell localization. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823544", "aliases": ["downregulation of horizontal cell localization", "down-regulation of retinal horizontal cell positioning", "downregulation of horizontal cell positioning", "down-regulation of laminar positioning of retinal horizontal cell", "down-regulation of horizontal cell localization", "downregulation of horizontal cell localisation", "down regulation of laminar positioning of retinal horizontal cell", "down regulation of horizontal cell positioning", "negative regulation of horizontal cell positioning", "negative regulation of laminar positioning of retinal horizontal cell", "downregulation of retinal horizontal cell positioning", "down regulation of horizontal cell localization", "down regulation of horizontal cell localisation", "down-regulation of horizontal cell positioning", "negative regulation of retinal horizontal cell positioning", "down-regulation of horizontal cell localisation", "negative regulation of horizontal cell localisation", "down regulation of retinal horizontal cell positioning", "downregulation of laminar positioning of retinal horizontal cell"], "types": ["T039"], "canonical_name": "negative regulation of horizontal cell localization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of horizontal cell localization. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823545", "aliases": ["inhibition of horizontal cell localization"], "types": ["T039"], "canonical_name": "inhibition of horizontal cell localisation"}
{"concept_id": "C3823546", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of horizontal cell positioning"}
{"concept_id": "C3823547", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of laminar positioning of retinal horizontal cell"}
{"concept_id": "C3823548", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of retinal horizontal cell positioning"}
{"concept_id": "C3823549", "aliases": ["up-regulation of retinal horizontal cell positioning", "positive regulation of laminar positioning of retinal horizontal cell", "upregulation of horizontal cell positioning", "positive regulation of horizontal cell positioning", "up regulation of laminar positioning of retinal horizontal cell", "up regulation of horizontal cell localisation", "up regulation of horizontal cell positioning", "up-regulation of laminar positioning of retinal horizontal cell", "up regulation of horizontal cell localization", "up regulation of retinal horizontal cell positioning", "upregulation of horizontal cell localisation", "upregulation of horizontal cell localization", "up-regulation of horizontal cell positioning", "upregulation of retinal horizontal cell positioning", "upregulation of laminar positioning of retinal horizontal cell", "up-regulation of horizontal cell localisation", "up-regulation of horizontal cell localization", "positive regulation of horizontal cell localisation", "positive regulation of retinal horizontal cell positioning"], "types": ["T039"], "canonical_name": "positive regulation of horizontal cell localization", "definition": "Any process that activates or increases the frequency, rate or extent of horizontal cell localization. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823550", "aliases": ["activation of horizontal cell localization"], "types": ["T039"], "canonical_name": "activation of horizontal cell localisation"}
{"concept_id": "C3823551", "aliases": [], "types": ["T039"], "canonical_name": "activation of horizontal cell positioning"}
{"concept_id": "C3823552", "aliases": [], "types": ["T039"], "canonical_name": "activation of laminar positioning of retinal horizontal cell"}
{"concept_id": "C3823553", "aliases": [], "types": ["T039"], "canonical_name": "activation of retinal horizontal cell positioning"}
{"concept_id": "C3823554", "aliases": [], "types": ["T040"], "canonical_name": "regulation of embryonic pattern specification", "definition": "Any process that modulates the frequency, rate or extent of embryonic pattern specification. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823555", "aliases": [], "types": ["T040"], "canonical_name": "regulation of embryonic pattern biosynthesis"}
{"concept_id": "C3823556", "aliases": [], "types": ["T040"], "canonical_name": "regulation of embryonic pattern formation"}
{"concept_id": "C3823557", "aliases": [], "types": ["T040"], "canonical_name": "regulation of ventral/lateral system"}
{"concept_id": "C3823558", "aliases": ["down regulation of embryonic pattern specification", "downregulation of embryonic pattern specification", "down-regulation of embryonic pattern specification"], "types": ["T039"], "canonical_name": "negative regulation of embryonic pattern specification", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823559", "aliases": ["down-regulation of ventral/lateral system"], "types": ["T039"], "canonical_name": "down regulation of ventral/lateral system"}
{"concept_id": "C3823560", "aliases": [], "types": ["T039"], "canonical_name": "downregulation of ventral/lateral system"}
{"concept_id": "C3823561", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of embryonic pattern specification"}
{"concept_id": "C3823562", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of ventral/lateral system"}
{"concept_id": "C3823563", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of ventral/lateral system"}
{"concept_id": "C3823564", "aliases": ["up regulation of embryonic pattern specification", "upregulation of embryonic pattern specification", "up-regulation of embryonic pattern specification"], "types": ["T039"], "canonical_name": "positive regulation of embryonic pattern specification", "definition": "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]"}
{"concept_id": "C3823565", "aliases": [], "types": ["T039"], "canonical_name": "activation of embryonic pattern specification"}
{"concept_id": "C3823566", "aliases": [], "types": ["T039"], "canonical_name": "activation of ventral/lateral system"}
{"concept_id": "C3823567", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of ventral/lateral system"}
{"concept_id": "C3823568", "aliases": ["up-regulation of ventral/lateral system"], "types": ["T039"], "canonical_name": "up regulation of ventral/lateral system"}
{"concept_id": "C3823569", "aliases": [], "types": ["T039"], "canonical_name": "upregulation of ventral/lateral system"}
{"concept_id": "C3823577", "aliases": ["downregulation of Rab GTPase activity", "negative regulation of Rab GTPase activity", "down-regulation of Rab GTPase activity"], "types": ["T044"], "canonical_name": "down regulation of Rab GTPase activity"}
{"concept_id": "C3823578", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Rab GTPase activity"}
{"concept_id": "C3823579", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to oxidative stress", "definition": "Any process that modulates the frequency, rate or extent of response to oxidative stress. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]"}
{"concept_id": "C3823580", "aliases": ["down regulation of response to oxidative stress", "down-regulation of response to oxidative stress", "downregulation of response to oxidative stress"], "types": ["T039"], "canonical_name": "negative regulation of response to oxidative stress", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]"}
{"concept_id": "C3823581", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of response to oxidative stress"}
{"concept_id": "C3823582", "aliases": ["upregulation of response to oxidative stress", "up-regulation of response to oxidative stress", "up regulation of response to oxidative stress"], "types": ["T039"], "canonical_name": "positive regulation of response to oxidative stress", "definition": "Any process that activates or increases the frequency, rate or extent of response to oxidative stress. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]"}
{"concept_id": "C3823583", "aliases": [], "types": ["T039"], "canonical_name": "activation of response to oxidative stress"}
{"concept_id": "C3823611", "aliases": ["protein localisation to astral microtubule", "protein localization in astral microtubule", "protein localisation in astral microtubule"], "types": ["T043"], "canonical_name": "protein localization to astral microtubule", "definition": "A process in which a protein is transported to, or maintained in, a location within an astral microtubule. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030]"}
{"concept_id": "C3823612", "aliases": ["protein localisation in spindle microtubule", "protein localization in spindle microtubule", "protein localisation to spindle microtubule"], "types": ["T043"], "canonical_name": "protein localization to spindle microtubule", "definition": "A process in which a protein is transported to, or maintained in, a location within a spindle microtubule. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030]"}
{"concept_id": "C3823613", "aliases": [], "types": ["T043"], "canonical_name": "regulation of root hair elongation", "definition": "Any process that modulates the frequency, rate or extent of root hair elongation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353]"}
{"concept_id": "C3823614", "aliases": ["down regulation of root hair elongation", "downregulation of root hair elongation", "down-regulation of root hair elongation"], "types": ["T043"], "canonical_name": "negative regulation of root hair elongation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of root hair elongation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353]"}
{"concept_id": "C3823615", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of root hair elongation"}
{"concept_id": "C3823616", "aliases": ["upregulation of root hair elongation", "up-regulation of root hair elongation", "up regulation of root hair elongation"], "types": ["T043"], "canonical_name": "positive regulation of root hair elongation", "definition": "Any process that activates or increases the frequency, rate or extent of root hair elongation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353]"}
{"concept_id": "C3823617", "aliases": [], "types": ["T043"], "canonical_name": "activation of root hair elongation"}
{"concept_id": "C3823618", "aliases": ["regulation of microRNA gene transcription", "regulation of miRNA gene transcription", "regulation of pri-miRNA transcription from RNA polymerase II promoter", "regulation of pri-miRNA transcription by RNA polymerase II", "regulation of primary miRNA gene transcription"], "types": ["T045"], "canonical_name": "regulation of miRNA transcription", "definition": "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]"}
{"concept_id": "C3823619", "aliases": ["negative regulation of pri-miRNA transcription by RNA polymerase II", "negative regulation of pri-miRNA transcription from RNA polymerase II promoter", "down regulation of pri-miRNA transcription from RNA polymerase II promoter", "negative regulation of primary miRNA gene transcription", "down-regulation of pri-miRNA transcription from RNA polymerase II promoter", "negative regulation of miRNA gene transcription", "negative regulation of microRNA gene transcription", "downregulation of pri-miRNA transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of miRNA transcription", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]"}
{"concept_id": "C3823620", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of pri-miRNA transcription from RNA polymerase II promoter"}
{"concept_id": "C3823621", "aliases": ["positive regulation of primary miRNA gene transcription", "positive regulation of pri-miRNA transcription by RNA polymerase II", "up-regulation of pri-miRNA transcription from RNA polymerase II promoter", "upregulation of pri-miRNA transcription from RNA polymerase II promoter", "positive regulation of pri-miRNA gene transcription", "up regulation of pri-miRNA transcription from RNA polymerase II promoter", "positive regulation of pri-miRNA transcription from RNA polymerase II promoter", "positive regulation of microRNA gene transcription"], "types": ["T045"], "canonical_name": "positive regulation of miRNA transcription", "definition": "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]"}
{"concept_id": "C3823622", "aliases": [], "types": ["T045"], "canonical_name": "activation of pri-miRNA transcription from RNA polymerase II promoter"}
{"concept_id": "C3823623", "aliases": ["terminal web formation"], "types": ["T043"], "canonical_name": "terminal web assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a terminal web. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, pmid:21949650]"}
{"concept_id": "C3823624", "aliases": ["regulation of PSD-95 clustering", "regulation of post-synaptic density protein 95 clustering", "regulation of Dlg4 clustering"], "types": ["T039"], "canonical_name": "regulation of postsynaptic density protein 95 clustering", "definition": "Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:10570482]"}
{"concept_id": "C3823625", "aliases": ["FAME metabolic process", "fatty acid methyl ester metabolism"], "types": ["T044"], "canonical_name": "fatty acid methyl ester metabolic process", "definition": "The chemical reactions and pathways involving fatty acid methyl ester. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218]"}
{"concept_id": "C3823626", "aliases": ["fatty acid methyl ester formation", "FAME biosynthetic process", "fatty acid methyl ester biosynthesis", "fatty acid methyl ester synthesis", "fatty acid methyl ester anabolism"], "types": ["T040"], "canonical_name": "fatty acid methyl ester biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fatty acid methyl ester. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218]"}
{"concept_id": "C3823627", "aliases": ["gut granule formation", "gut granule biogenesis"], "types": ["T043"], "canonical_name": "gut granule assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a gut granule. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, pmid:17202409]"}
{"concept_id": "C3823628", "aliases": ["upregulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion", "up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress", "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress", "activation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress", "stimulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion", "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress", "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress", "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress", "up regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion", "up-regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion", "positive regulation of transcription from Pol II promoter involved in response to cadmium ion stress", "activation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion", "positive regulation of transcription from Pol II promoter involved in stress response to cadmium ion"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion", "definition": "Any positive regulation of transcription from RNA polymerase II promoter that is involved in stress response to cadmium ion. [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:17888400]"}
{"concept_id": "C3823629", "aliases": ["activation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion"], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress"}
{"concept_id": "C3823630", "aliases": [], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823631", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823632", "aliases": ["positive regulation of gene-specific transcription from RNA polymerase II promoter involved in stress response to cadmium ion"], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium ion stress"}
{"concept_id": "C3823633", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823634", "aliases": ["positive regulation of global transcription from Pol II promoter involved in stress response to cadmium ion"], "types": ["T045"], "canonical_name": "positive regulation of global transcription from Pol II promoter involved in response to cadmium ion stress"}
{"concept_id": "C3823635", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of global transcription from Pol II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823636", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from Pol II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823637", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823638", "aliases": ["stimulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion"], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress"}
{"concept_id": "C3823639", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823640", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823641", "aliases": ["up-regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion", "up regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion", "up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress"], "types": ["T045"], "canonical_name": "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress"}
{"concept_id": "C3823642", "aliases": ["up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity"], "types": ["T045"], "canonical_name": "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823643", "aliases": ["up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity"], "types": ["T045"], "canonical_name": "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823644", "aliases": ["upregulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion"], "types": ["T045"], "canonical_name": "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress"}
{"concept_id": "C3823645", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823646", "aliases": [], "types": ["T045"], "canonical_name": "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity"}
{"concept_id": "C3823647", "aliases": ["negative regulation of autophagosome biosynthesis", "down regulation of autophagosome formation", "negative regulation of autophagosome formation", "down regulation of autophagic vacuole assembly", "down regulation of autophagosome biosynthesis", "downregulation of autophagosome biosynthesis", "down-regulation of autophagosome formation", "negative regulation of autophagic vacuole assembly", "downregulation of autophagic vacuole assembly", "down-regulation of autophagosome biosynthesis", "downregulation of autophagosome formation", "down-regulation of autophagic vacuole assembly"], "types": ["T043"], "canonical_name": "negative regulation of autophagosome assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly. [GO_REF:0000058, GOC:als, GOC:autophagy, GOC:TermGenie, PMID:21975012]"}
{"concept_id": "C3823648", "aliases": ["down-regulation of autophagic vacuole formation"], "types": ["T043"], "canonical_name": "down regulation of autophagic vacuole formation"}
{"concept_id": "C3823649", "aliases": ["down-regulation of PAS formation"], "types": ["T043"], "canonical_name": "down regulation of PAS formation"}
{"concept_id": "C3823650", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of autophagic vacuole formation"}
{"concept_id": "C3823651", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of PAS formation"}
{"concept_id": "C3823652", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of autophagic vacuole assembly"}
{"concept_id": "C3823653", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of autophagic vacuole formation"}
{"concept_id": "C3823654", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of autophagosome biosynthesis"}
{"concept_id": "C3823655", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of autophagosome formation"}
{"concept_id": "C3823656", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of PAS formation"}
{"concept_id": "C3823657", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of autophagic vacuole formation"}
{"concept_id": "C3823658", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of PAS formation"}
{"concept_id": "C3823659", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fibril organisation"}
{"concept_id": "C3823660", "aliases": ["down-regulation of fibril organization", "downregulation of fibril organization", "downregulation of fibril organisation", "down-regulation of fibril organisation", "negative regulation of fibril organisation", "down regulation of fibril organization"], "types": ["T043"], "canonical_name": "down regulation of fibril organisation"}
{"concept_id": "C3823661", "aliases": ["inhibition of fibril organization"], "types": ["T043"], "canonical_name": "inhibition of fibril organisation"}
{"concept_id": "C3823662", "aliases": ["up-regulation of fibril organization", "up-regulation of fibril organisation", "upregulation of fibril organization", "up regulation of fibril organization", "positive regulation of fibril organisation", "upregulation of fibril organisation"], "types": ["T043"], "canonical_name": "up regulation of fibril organisation"}
{"concept_id": "C3823663", "aliases": ["activation of fibril organization"], "types": ["T043"], "canonical_name": "activation of fibril organisation"}
{"concept_id": "C3823664", "aliases": ["PSG assembly", "PSG formation", "proteasome storage granule formation"], "types": ["T044"], "canonical_name": "proteasome storage granule assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a proteasome storage granule. [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178]"}
{"concept_id": "C3823665", "aliases": ["PSG disassembly"], "types": ["T044"], "canonical_name": "proteasome storage granule disassembly", "definition": "The disaggregation of a proteasome storage granule into its constituent components. [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178]"}
{"concept_id": "C3823666", "aliases": [], "types": ["T043"], "canonical_name": "regulation of melanosome transport", "definition": "Any process that modulates the frequency, rate or extent of melanosome transport. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344]"}
{"concept_id": "C3823667", "aliases": ["downregulation of melanosome transport", "down-regulation of melanosome transport", "down regulation of melanosome transport"], "types": ["T043"], "canonical_name": "negative regulation of melanosome transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome transport. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344]"}
{"concept_id": "C3823668", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of melanosome transport"}
{"concept_id": "C3823669", "aliases": ["upregulation of melanosome transport", "up-regulation of melanosome transport", "up regulation of melanosome transport"], "types": ["T043"], "canonical_name": "positive regulation of melanosome transport", "definition": "Any process that activates or increases the frequency, rate or extent of melanosome transport. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344]"}
{"concept_id": "C3823670", "aliases": [], "types": ["T043"], "canonical_name": "activation of melanosome transport"}
{"concept_id": "C3823671", "aliases": ["protein kinase complex location"], "types": ["T026"], "canonical_name": "protein kinase complex", "definition": "A protein complex which is capable of protein kinase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]"}
{"concept_id": "C3823672", "aliases": ["pyruvate kinase complex location"], "types": ["T026"], "canonical_name": "pyruvate kinase complex", "definition": "A protein complex which is capable of pyruvate kinase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]"}
{"concept_id": "C3823673", "aliases": ["up regulation of neuroepithelial cell differentiation", "up-regulation of neuroepithelial cell differentiation", "upregulation of neuroepithelial cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of neuroepithelial cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506]"}
{"concept_id": "C3823674", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuroepithelial cell differentiation"}
{"concept_id": "C3823675", "aliases": ["regulation of protein polyubiquitinylation", "regulation of protein polyubiquitylation"], "types": ["T044"], "canonical_name": "regulation of protein polyubiquitination", "definition": "Any process that modulates the frequency, rate or extent of protein polyubiquitination. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]"}
{"concept_id": "C3823676", "aliases": [], "types": ["T044"], "canonical_name": "regulation of polyubiquitin"}
{"concept_id": "C3823677", "aliases": ["downregulation of protein polyubiquitylation", "down-regulation of protein polyubiquitination", "downregulation of protein polyubiquitination", "down regulation of protein polyubiquitylation", "down regulation of protein polyubiquitination", "negative regulation of protein polyubiquitylation", "negative regulation of protein polyubiquitinylation", "down regulation of protein polyubiquitinylation", "down-regulation of protein polyubiquitylation", "downregulation of protein polyubiquitinylation", "down-regulation of protein polyubiquitinylation"], "types": ["T044"], "canonical_name": "negative regulation of protein polyubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]"}
{"concept_id": "C3823678", "aliases": ["down-regulation of polyubiquitin"], "types": ["T044"], "canonical_name": "down regulation of polyubiquitin"}
{"concept_id": "C3823679", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of polyubiquitin"}
{"concept_id": "C3823680", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polyubiquitin"}
{"concept_id": "C3823681", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein polyubiquitination"}
{"concept_id": "C3823682", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein polyubiquitinylation"}
{"concept_id": "C3823683", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein polyubiquitylation"}
{"concept_id": "C3823684", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of polyubiquitin"}
{"concept_id": "C3823685", "aliases": ["upregulation of protein polyubiquitinylation", "up-regulation of protein polyubiquitination", "up-regulation of protein polyubiquitylation", "upregulation of protein polyubiquitination", "up-regulation of protein polyubiquitinylation", "up regulation of protein polyubiquitylation", "up regulation of protein polyubiquitination", "up regulation of protein polyubiquitinylation", "upregulation of protein polyubiquitylation", "positive regulation of protein polyubiquitylation", "positive regulation of protein polyubiquitinylation"], "types": ["T044"], "canonical_name": "positive regulation of protein polyubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of protein polyubiquitination. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]"}
{"concept_id": "C3823686", "aliases": [], "types": ["T044"], "canonical_name": "activation of polyubiquitin"}
{"concept_id": "C3823687", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein polyubiquitination"}
{"concept_id": "C3823688", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein polyubiquitinylation"}
{"concept_id": "C3823689", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein polyubiquitylation"}
{"concept_id": "C3823690", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of polyubiquitin"}
{"concept_id": "C3823691", "aliases": ["up-regulation of polyubiquitin"], "types": ["T044"], "canonical_name": "up regulation of polyubiquitin"}
{"concept_id": "C3823692", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of polyubiquitin"}
{"concept_id": "C3823693", "aliases": ["up regulation of mating projection assembly", "upregulation of mating projection assembly", "up-regulation of mating projection assembly"], "types": ["T043"], "canonical_name": "positive regulation of mating projection assembly", "definition": "Any process that activates or increases the frequency, rate or extent of mating projection assembly. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:12455985]"}
{"concept_id": "C3823694", "aliases": [], "types": ["T043"], "canonical_name": "activation of mating projection assembly"}
{"concept_id": "C3823695", "aliases": [], "types": ["T043"], "canonical_name": "activation of mating projection biogenesis"}
{"concept_id": "C3823696", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mating projection biogenesis"}
{"concept_id": "C3823697", "aliases": ["up-regulation of mating projection biogenesis"], "types": ["T043"], "canonical_name": "up regulation of mating projection biogenesis"}
{"concept_id": "C3823698", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of mating projection biogenesis"}
{"concept_id": "C3823699", "aliases": ["poly(5-hydroxyvalerate) metabolism"], "types": ["T044"], "canonical_name": "poly(5-hydroxyvalerate) metabolic process", "definition": "The chemical reactions and pathways involving poly(5-hydroxyvalerate). [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]"}
{"concept_id": "C3823700", "aliases": ["poly(5-hydroxyvalerate) formation", "poly(5-hydroxyvalerate) anabolism", "poly(5-hydroxyvalerate) biosynthesis", "poly(5-hydroxyvalerate) synthesis"], "types": ["T044"], "canonical_name": "poly(5-hydroxyvalerate) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly(5-hydroxyvalerate). [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]"}
{"concept_id": "C3823701", "aliases": ["poly(hydroxyvalerate) metabolism"], "types": ["T044"], "canonical_name": "poly(hydroxyvalerate) metabolic process", "definition": "The chemical reactions and pathways involving poly(hydroxyvalerate). [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]"}
{"concept_id": "C3823702", "aliases": ["poly(hydroxyvalerate) anabolism", "poly(hydroxyvalerate) formation", "poly(hydroxyvalerate) synthesis", "poly(hydroxyvalerate) biosynthesis"], "types": ["T044"], "canonical_name": "poly(hydroxyvalerate) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly(hydroxyvalerate). [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]"}
{"concept_id": "C3823703", "aliases": ["poly(3-hydroxyvalerate) metabolism"], "types": ["T044"], "canonical_name": "poly(3-hydroxyvalerate) metabolic process", "definition": "The chemical reactions and pathways involving poly(3-hydroxyvalerate). [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]"}
{"concept_id": "C3823704", "aliases": ["poly(3-hydroxyvalerate) formation", "poly(3-hydroxyvalerate) synthesis", "poly(3-hydroxyvalerate) anabolism", "poly(3-hydroxyvalerate) biosynthesis"], "types": ["T044"], "canonical_name": "poly(3-hydroxyvalerate) biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyvalerate). [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]"}
{"concept_id": "C3823705", "aliases": ["poly(hydroxyalkanoate) formation from glucose", "poly(hydroxyalkanoate) biosynthesis from glucose", "poly(hydroxyalkanoate) anabolism from glucose", "poly(hydroxyalkanoate) synthesis from glucose"], "types": ["T044"], "canonical_name": "poly(hydroxyalkanoate) biosynthetic process from glucose", "definition": "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from glucose. [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:24425304]"}
{"concept_id": "C3823706", "aliases": ["poly(hydroxyalkanoate) anabolism from fatty acid", "poly(hydroxyalkanoate) formation from fatty acid", "poly(hydroxyalkanoate) biosynthesis from fatty acid", "poly(hydroxyalkanoate) synthesis from fatty acid"], "types": ["T044"], "canonical_name": "poly(hydroxyalkanoate) biosynthetic process from fatty acid", "definition": "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from fatty acid. [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:21129764]"}
{"concept_id": "C3823707", "aliases": ["inulin metabolism"], "types": ["T044"], "canonical_name": "inulin metabolic process", "definition": "The chemical reactions and pathways involving inulin. [GO_REF:0000068, GOC:TermGenie, PMID:23104410]"}
{"concept_id": "C3823708", "aliases": ["inulin breakdown", "inulin catabolism", "inulin degradation"], "types": ["T044"], "canonical_name": "inulin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of inulin. [GO_REF:0000068, GOC:TermGenie, PMID:23104410]"}
{"concept_id": "C3823709", "aliases": ["inulin formation", "inulin biosynthesis", "inulin synthesis", "inulin anabolism"], "types": ["T044"], "canonical_name": "inulin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of inulin. [GO_REF:0000068, GOC:TermGenie, PMID:23104410]"}
{"concept_id": "C3823710", "aliases": ["growing cell tip plasma membrane part", "plasma membrane part of growing cell tip", "plasma membrane part of growing cell end"], "types": ["T026"], "canonical_name": "plasma membrane of growing cell tip", "definition": "Any plasma membrane part that is part of a growing cell tip. [GO_REF:0000064, GOC:TermGenie, PMID:17085965]"}
{"concept_id": "C3823711", "aliases": ["regulation of alcohol anabolism", "regulation of alcohol formation", "regulation of alcohol biosynthesis", "regulation of alcohol synthesis"], "types": ["T044"], "canonical_name": "regulation of alcohol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]"}
{"concept_id": "C3823712", "aliases": [], "types": ["T044"], "canonical_name": "regulation of solventogenesis"}
{"concept_id": "C3823713", "aliases": ["downregulation of alcohol formation", "down-regulation of alcohol anabolism", "downregulation of alcohol biosynthetic process", "negative regulation of alcohol anabolism", "down regulation of alcohol synthesis", "down-regulation of alcohol biosynthesis", "down-regulation of alcohol synthesis", "down regulation of alcohol biosynthetic process", "down regulation of alcohol formation", "downregulation of alcohol biosynthesis", "negative regulation of alcohol synthesis", "downregulation of alcohol anabolism", "down-regulation of alcohol biosynthetic process", "down regulation of alcohol biosynthesis", "negative regulation of alcohol formation", "negative regulation of alcohol biosynthesis", "down-regulation of alcohol formation", "down regulation of alcohol anabolism", "downregulation of alcohol synthesis"], "types": ["T044"], "canonical_name": "negative regulation of alcohol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]"}
{"concept_id": "C3823714", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of alcohol anabolism"}
{"concept_id": "C3823715", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of alcohol biosynthesis"}
{"concept_id": "C3823716", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of alcohol biosynthetic process"}
{"concept_id": "C3823717", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of alcohol formation"}
{"concept_id": "C3823718", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of alcohol synthesis"}
{"concept_id": "C3823719", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of solventogenesis"}
{"concept_id": "C3823720", "aliases": ["upregulation of alcohol biosynthesis", "up-regulation of alcohol anabolism", "upregulation of alcohol biosynthetic process", "up-regulation of alcohol synthesis", "upregulation of alcohol synthesis", "positive regulation of alcohol biosynthesis", "positive regulation of alcohol synthesis", "positive regulation of alcohol anabolism", "up-regulation of alcohol biosynthesis", "positive regulation of alcohol formation", "up regulation of alcohol biosynthetic process", "up-regulation of alcohol formation", "up regulation of alcohol biosynthesis", "up regulation of alcohol synthesis", "up regulation of alcohol anabolism", "up regulation of alcohol formation", "up-regulation of alcohol biosynthetic process", "upregulation of alcohol anabolism", "upregulation of alcohol formation"], "types": ["T044"], "canonical_name": "positive regulation of alcohol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]"}
{"concept_id": "C3823721", "aliases": [], "types": ["T044"], "canonical_name": "activation of alcohol anabolism"}
{"concept_id": "C3823722", "aliases": [], "types": ["T044"], "canonical_name": "activation of alcohol biosynthesis"}
{"concept_id": "C3823723", "aliases": [], "types": ["T044"], "canonical_name": "activation of alcohol biosynthetic process"}
{"concept_id": "C3823724", "aliases": [], "types": ["T044"], "canonical_name": "activation of alcohol formation"}
{"concept_id": "C3823725", "aliases": [], "types": ["T044"], "canonical_name": "activation of alcohol synthesis"}
{"concept_id": "C3823726", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of solventogenesis"}
{"concept_id": "C3823727", "aliases": ["isopentenol metabolism"], "types": ["T044"], "canonical_name": "isopentenol metabolic process", "definition": "The chemical reactions and pathways involving isopentenol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564]"}
{"concept_id": "C3823728", "aliases": ["isopentenol formation", "isopentenol synthesis", "isopentenol anabolism", "isopentenol biosynthesis"], "types": ["T044"], "canonical_name": "isopentenol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of isopentenol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564]"}
{"concept_id": "C3823729", "aliases": ["protein localisation to septin ring", "protein localization in septin ring", "protein localisation in septin ring"], "types": ["T043"], "canonical_name": "protein localization to septin ring", "definition": "A process in which a protein is transported to, or maintained in, a location within a septin ring. [GO_REF:0000087, GOC:TermGenie, PMID:16325501]"}
{"concept_id": "C3823730", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol bisphosphate binding", "definition": "Binding to phosphatidylinositol bisphosphate. [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]"}
{"concept_id": "C3823731", "aliases": ["inward rectifier potassium channel complex location"], "types": ["T026"], "canonical_name": "inward rectifier potassium channel complex", "definition": "A protein complex which is capable of inward rectifier potassium channel activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16834334]"}
{"concept_id": "C3823732", "aliases": [], "types": ["T039"], "canonical_name": "regulation of intracellular calcium activated chloride channel activity", "definition": "Any process that modulates the frequency, rate or extent of intracellular calcium activated chloride channel activity. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059]"}
{"concept_id": "C3823733", "aliases": ["down regulation of intracellular calcium activated chloride channel activity", "down-regulation of intracellular calcium activated chloride channel activity", "downregulation of intracellular calcium activated chloride channel activity"], "types": ["T039"], "canonical_name": "negative regulation of intracellular calcium activated chloride channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular calcium activated chloride channel activity. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059]"}
{"concept_id": "C3823734", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of intracellular calcium activated chloride channel activity"}
{"concept_id": "C3823735", "aliases": ["upregulation of intracellular calcium activated chloride channel activity", "up-regulation of intracellular calcium activated chloride channel activity", "up regulation of intracellular calcium activated chloride channel activity"], "types": ["T039"], "canonical_name": "positive regulation of intracellular calcium activated chloride channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of intracellular calcium activated chloride channel activity. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059]"}
{"concept_id": "C3823736", "aliases": [], "types": ["T039"], "canonical_name": "activation of intracellular calcium activated chloride channel activity"}
{"concept_id": "C3823737", "aliases": ["regulation of voltage-dependent chloride channel activity", "regulation of voltage gated chloride channel activity"], "types": ["T039"], "canonical_name": "regulation of voltage-gated chloride channel activity", "definition": "Any process that modulates the frequency, rate or extent of voltage-gated chloride channel activity. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]"}
{"concept_id": "C3823738", "aliases": ["downregulation of voltage-gated chloride channel activity", "down regulation of voltage gated chloride channel activity", "down regulation of voltage-dependent chloride channel activity", "downregulation of voltage-dependent chloride channel activity", "negative regulation of voltage gated chloride channel activity", "down regulation of voltage-gated chloride channel activity", "down-regulation of voltage gated chloride channel activity", "down-regulation of voltage-gated chloride channel activity", "negative regulation of voltage-dependent chloride channel activity", "downregulation of voltage gated chloride channel activity", "down-regulation of voltage-dependent chloride channel activity"], "types": ["T039"], "canonical_name": "negative regulation of voltage-gated chloride channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated chloride channel activity. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]"}
{"concept_id": "C3823739", "aliases": ["inhibition of voltage-gated chloride channel activity"], "types": ["T039"], "canonical_name": "inhibition of voltage gated chloride channel activity"}
{"concept_id": "C3823740", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of voltage-dependent chloride channel activity"}
{"concept_id": "C3823741", "aliases": ["positive regulation of voltage-dependent chloride channel activity", "up regulation of voltage-gated chloride channel activity", "up regulation of voltage gated chloride channel activity", "upregulation of voltage-gated chloride channel activity", "positive regulation of voltage gated chloride channel activity", "up-regulation of voltage-dependent chloride channel activity", "up-regulation of voltage-gated chloride channel activity", "upregulation of voltage gated chloride channel activity", "upregulation of voltage-dependent chloride channel activity", "up-regulation of voltage gated chloride channel activity", "up regulation of voltage-dependent chloride channel activity"], "types": ["T039"], "canonical_name": "positive regulation of voltage-gated chloride channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]"}
{"concept_id": "C3823742", "aliases": ["activation of voltage-gated chloride channel activity"], "types": ["T039"], "canonical_name": "activation of voltage gated chloride channel activity"}
{"concept_id": "C3823743", "aliases": [], "types": ["T039"], "canonical_name": "activation of voltage-dependent chloride channel activity"}
{"concept_id": "C3823744", "aliases": ["aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "aspartic-type endopeptidase activity involved in APP catabolic process", "aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "aspartic-type endopeptidase activity involved in APP catabolism", "aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "aspartic endopeptidase activity involved in APP catabolism", "aspartic endopeptidase activity involved in amyloid precursor protein degradation", "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "aspartic endopeptidase activity involved in APP catabolic process", "aspartic endopeptidase activity involved in amyloid precursor protein catabolic process"], "types": ["T044"], "canonical_name": "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "definition": "Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process. [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:10206644, PMID:24577224]"}
{"concept_id": "C3823745", "aliases": ["metalloendopeptidase activity involved in amyloid precursor protein breakdown", "metalloendopeptidase activity involved in APP catabolic process", "metalloendopeptidase activity involved in amyloid precursor protein degradation", "metalloendopeptidase activity involved in APP catabolism", "metalloendopeptidase activity involved in amyloid precursor protein catabolism"], "types": ["T044"], "canonical_name": "metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "definition": "Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process. [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:14598310, PMID:17855360]"}
{"concept_id": "C3823746", "aliases": ["protein localisation in early endosome", "protein localisation to early endosome", "protein localization in early endosome"], "types": ["T043"], "canonical_name": "protein localization to early endosome", "definition": "A process in which a protein is transported to, or maintained in, a location within an early endosome. [GO_REF:0000087, GOC:sjp, GOC:TermGenie, PMID:22621900]"}
{"concept_id": "C3823747", "aliases": ["regulation of tau protein kinase activity", "regulation of glycogen synthase kinase-3beta activity", "regulation of tau kinase activity", "regulation of [Tau protein] kinase activity", "regulation of protein tau kinase activity"], "types": ["T043"], "canonical_name": "regulation of tau-protein kinase activity", "definition": "Any process that modulates the frequency, rate or extent of tau-protein kinase activity. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]"}
{"concept_id": "C3823748", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ATP:tau-protein O-phosphotransferase activity"}
{"concept_id": "C3823749", "aliases": [], "types": ["T043"], "canonical_name": "regulation of brain protein kinase PK40erk activity"}
{"concept_id": "C3823750", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cdk5/p20"}
{"concept_id": "C3823751", "aliases": [], "types": ["T043"], "canonical_name": "regulation of CDK5/p23"}
{"concept_id": "C3823752", "aliases": [], "types": ["T043"], "canonical_name": "regulation of GSK"}
{"concept_id": "C3823753", "aliases": [], "types": ["T043"], "canonical_name": "regulation of STK31"}
{"concept_id": "C3823754", "aliases": [], "types": ["T043"], "canonical_name": "regulation of tau-protein kinase I activity"}
{"concept_id": "C3823755", "aliases": [], "types": ["T043"], "canonical_name": "regulation of tau-protein kinase II activity"}
{"concept_id": "C3823756", "aliases": [], "types": ["T043"], "canonical_name": "regulation of tau-tubulin kinase activity"}
{"concept_id": "C3823757", "aliases": [], "types": ["T043"], "canonical_name": "regulation of TPK"}
{"concept_id": "C3823758", "aliases": [], "types": ["T043"], "canonical_name": "regulation of TPK I"}
{"concept_id": "C3823759", "aliases": [], "types": ["T043"], "canonical_name": "regulation of TPK II"}
{"concept_id": "C3823760", "aliases": [], "types": ["T043"], "canonical_name": "regulation of TTK"}
{"concept_id": "C3823761", "aliases": ["down regulation of glycogen synthase kinase-3beta activity", "down-regulation of [Tau protein] kinase activity", "negative regulation of glycogen synthase kinase-3beta activity", "down regulation of tau protein kinase activity", "down-regulation of protein tau kinase activity", "downregulation of tau-protein kinase activity", "down-regulation of tau kinase activity", "negative regulation of tau kinase activity", "downregulation of protein tau kinase activity", "down regulation of tau-protein kinase activity", "negative regulation of protein tau kinase activity", "negative regulation of [Tau protein] kinase activity", "down regulation of tau kinase activity", "downregulation of tau kinase activity", "down-regulation of glycogen synthase kinase-3beta activity", "down-regulation of tau-protein kinase activity", "downregulation of glycogen synthase kinase-3beta activity", "downregulation of [Tau protein] kinase activity", "down regulation of protein tau kinase activity", "down regulation of [Tau protein] kinase activity", "downregulation of tau protein kinase activity", "down-regulation of tau protein kinase activity", "negative regulation of tau protein kinase activity"], "types": ["T043"], "canonical_name": "negative regulation of tau-protein kinase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]"}
{"concept_id": "C3823762", "aliases": ["down-regulation of brain protein kinase PK40erk activity"], "types": ["T043"], "canonical_name": "down regulation of brain protein kinase PK40erk activity"}
{"concept_id": "C3823763", "aliases": ["down-regulation of cdk5/p20"], "types": ["T043"], "canonical_name": "down regulation of cdk5/p20"}
{"concept_id": "C3823764", "aliases": ["down-regulation of CDK5/p23"], "types": ["T043"], "canonical_name": "down regulation of CDK5/p23"}
{"concept_id": "C3823765", "aliases": ["down-regulation of GSK"], "types": ["T043"], "canonical_name": "down regulation of GSK"}
{"concept_id": "C3823766", "aliases": ["down-regulation of STK31"], "types": ["T043"], "canonical_name": "down regulation of STK31"}
{"concept_id": "C3823767", "aliases": ["down-regulation of tau-protein kinase I activity"], "types": ["T043"], "canonical_name": "down regulation of tau-protein kinase I activity"}
{"concept_id": "C3823768", "aliases": ["down-regulation of tau-protein kinase II activity"], "types": ["T043"], "canonical_name": "down regulation of tau-protein kinase II activity"}
{"concept_id": "C3823769", "aliases": ["down-regulation of tau-tubulin kinase activity"], "types": ["T043"], "canonical_name": "down regulation of tau-tubulin kinase activity"}
{"concept_id": "C3823770", "aliases": ["down-regulation of TPK"], "types": ["T043"], "canonical_name": "down regulation of TPK"}
{"concept_id": "C3823771", "aliases": ["down-regulation of TPK I"], "types": ["T043"], "canonical_name": "down regulation of TPK I"}
{"concept_id": "C3823772", "aliases": ["down-regulation of TPK II"], "types": ["T043"], "canonical_name": "down regulation of TPK II"}
{"concept_id": "C3823773", "aliases": ["down-regulation of TTK"], "types": ["T043"], "canonical_name": "down regulation of TTK"}
{"concept_id": "C3823774", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of brain protein kinase PK40erk activity"}
{"concept_id": "C3823775", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of cdk5/p20"}
{"concept_id": "C3823776", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of CDK5/p23"}
{"concept_id": "C3823777", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of GSK"}
{"concept_id": "C3823778", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of STK31"}
{"concept_id": "C3823779", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of tau-protein kinase I activity"}
{"concept_id": "C3823780", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of tau-protein kinase II activity"}
{"concept_id": "C3823781", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of tau-tubulin kinase activity"}
{"concept_id": "C3823782", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of TPK"}
{"concept_id": "C3823783", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of TPK I"}
{"concept_id": "C3823784", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of TPK II"}
{"concept_id": "C3823785", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of TTK"}
{"concept_id": "C3823786", "aliases": ["inhibition of tau-protein kinase activity", "inhibition of protein tau kinase activity", "inhibition of tau protein kinase activity"], "types": ["T043"], "canonical_name": "inhibition of [Tau protein] kinase activity"}
{"concept_id": "C3823787", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of brain protein kinase PK40erk activity"}
{"concept_id": "C3823788", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cdk5/p20"}
{"concept_id": "C3823789", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of CDK5/p23"}
{"concept_id": "C3823790", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glycogen synthase kinase-3beta activity"}
{"concept_id": "C3823791", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of GSK"}
{"concept_id": "C3823792", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of STK31"}
{"concept_id": "C3823793", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of tau kinase activity"}
{"concept_id": "C3823794", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of tau-protein kinase I activity"}
{"concept_id": "C3823795", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of tau-protein kinase II activity"}
{"concept_id": "C3823796", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of tau-tubulin kinase activity"}
{"concept_id": "C3823797", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of TPK"}
{"concept_id": "C3823798", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of TPK I"}
{"concept_id": "C3823799", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of TPK II"}
{"concept_id": "C3823800", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of TTK"}
{"concept_id": "C3823801", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of brain protein kinase PK40erk activity"}
{"concept_id": "C3823802", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CDK5/p23"}
{"concept_id": "C3823803", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of GSK"}
{"concept_id": "C3823804", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of STK31"}
{"concept_id": "C3823805", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of tau-protein kinase I activity"}
{"concept_id": "C3823806", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of tau-protein kinase II activity"}
{"concept_id": "C3823807", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of tau-tubulin kinase activity"}
{"concept_id": "C3823808", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of TPK"}
{"concept_id": "C3823809", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of TPK I"}
{"concept_id": "C3823810", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of TPK II"}
{"concept_id": "C3823811", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of TTK"}
{"concept_id": "C3823812", "aliases": ["upregulation of tau kinase activity", "upregulation of protein tau kinase activity", "up-regulation of glycogen synthase kinase-3beta activity", "upregulation of glycogen synthase kinase-3beta activity", "up regulation of [Tau protein] kinase activity", "up-regulation of tau-protein kinase activity", "positive regulation of tau kinase activity", "upregulation of tau protein kinase activity", "up regulation of tau-protein kinase activity", "positive regulation of glycogen synthase kinase-3beta activity", "up-regulation of tau protein kinase activity", "up regulation of tau protein kinase activity", "positive regulation of tau protein kinase activity", "up-regulation of tau kinase activity", "upregulation of tau-protein kinase activity", "up-regulation of [Tau protein] kinase activity", "upregulation of [Tau protein] kinase activity", "up regulation of protein tau kinase activity", "up regulation of tau kinase activity", "up-regulation of protein tau kinase activity", "positive regulation of protein tau kinase activity", "positive regulation of [Tau protein] kinase activity", "up regulation of glycogen synthase kinase-3beta activity"], "types": ["T043"], "canonical_name": "positive regulation of tau-protein kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]"}
{"concept_id": "C3823813", "aliases": ["activation of protein tau kinase activity", "activation of tau protein kinase activity", "activation of tau-protein kinase activity"], "types": ["T043"], "canonical_name": "activation of [Tau protein] kinase activity"}
{"concept_id": "C3823814", "aliases": [], "types": ["T043"], "canonical_name": "activation of brain protein kinase PK40erk activity"}
{"concept_id": "C3823815", "aliases": [], "types": ["T043"], "canonical_name": "activation of cdk5/p20"}
{"concept_id": "C3823816", "aliases": [], "types": ["T043"], "canonical_name": "activation of CDK5/p23"}
{"concept_id": "C3823817", "aliases": [], "types": ["T043"], "canonical_name": "activation of glycogen synthase kinase-3beta activity"}
{"concept_id": "C3823818", "aliases": [], "types": ["T043"], "canonical_name": "activation of GSK"}
{"concept_id": "C3823819", "aliases": [], "types": ["T043"], "canonical_name": "activation of STK31"}
{"concept_id": "C3823820", "aliases": [], "types": ["T043"], "canonical_name": "activation of tau kinase activity"}
{"concept_id": "C3823821", "aliases": [], "types": ["T043"], "canonical_name": "activation of tau-protein kinase I activity"}
{"concept_id": "C3823822", "aliases": [], "types": ["T043"], "canonical_name": "activation of tau-protein kinase II activity"}
{"concept_id": "C3823823", "aliases": [], "types": ["T043"], "canonical_name": "activation of tau-tubulin kinase activity"}
{"concept_id": "C3823824", "aliases": [], "types": ["T043"], "canonical_name": "activation of TPK"}
{"concept_id": "C3823825", "aliases": [], "types": ["T043"], "canonical_name": "activation of TPK I"}
{"concept_id": "C3823826", "aliases": [], "types": ["T043"], "canonical_name": "activation of TPK II"}
{"concept_id": "C3823827", "aliases": [], "types": ["T043"], "canonical_name": "activation of TTK"}
{"concept_id": "C3823828", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of brain protein kinase PK40erk activity"}
{"concept_id": "C3823829", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cdk5/p20"}
{"concept_id": "C3823830", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CDK5/p23"}
{"concept_id": "C3823831", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of GSK"}
{"concept_id": "C3823832", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of STK31"}
{"concept_id": "C3823833", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of tau-protein kinase II activity"}
{"concept_id": "C3823834", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of tau-tubulin kinase activity"}
{"concept_id": "C3823835", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of TPK"}
{"concept_id": "C3823836", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of TPK I"}
{"concept_id": "C3823837", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of TPK II"}
{"concept_id": "C3823838", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of TTK"}
{"concept_id": "C3823839", "aliases": ["up-regulation of brain protein kinase PK40erk activity"], "types": ["T043"], "canonical_name": "up regulation of brain protein kinase PK40erk activity"}
{"concept_id": "C3823840", "aliases": ["up-regulation of cdk5/p20"], "types": ["T043"], "canonical_name": "up regulation of cdk5/p20"}
{"concept_id": "C3823841", "aliases": ["up-regulation of CDK5/p23"], "types": ["T043"], "canonical_name": "up regulation of CDK5/p23"}
{"concept_id": "C3823842", "aliases": ["up-regulation of GSK"], "types": ["T043"], "canonical_name": "up regulation of GSK"}
{"concept_id": "C3823843", "aliases": ["up-regulation of STK31"], "types": ["T043"], "canonical_name": "up regulation of STK31"}
{"concept_id": "C3823844", "aliases": ["up-regulation of tau-protein kinase I activity"], "types": ["T043"], "canonical_name": "up regulation of tau-protein kinase I activity"}
{"concept_id": "C3823845", "aliases": ["up-regulation of tau-protein kinase II activity"], "types": ["T043"], "canonical_name": "up regulation of tau-protein kinase II activity"}
{"concept_id": "C3823846", "aliases": ["up-regulation of tau-tubulin kinase activity"], "types": ["T043"], "canonical_name": "up regulation of tau-tubulin kinase activity"}
{"concept_id": "C3823847", "aliases": ["up-regulation of TPK"], "types": ["T043"], "canonical_name": "up regulation of TPK"}
{"concept_id": "C3823848", "aliases": ["up-regulation of TPK I"], "types": ["T043"], "canonical_name": "up regulation of TPK I"}
{"concept_id": "C3823849", "aliases": ["up-regulation of TPK II"], "types": ["T043"], "canonical_name": "up regulation of TPK II"}
{"concept_id": "C3823850", "aliases": ["up-regulation of TTK"], "types": ["T043"], "canonical_name": "up regulation of TTK"}
{"concept_id": "C3823851", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of brain protein kinase PK40erk activity"}
{"concept_id": "C3823852", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of cdk5/p20"}
{"concept_id": "C3823853", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of CDK5/p23"}
{"concept_id": "C3823854", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of GSK"}
{"concept_id": "C3823855", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of tau-protein kinase I activity"}
{"concept_id": "C3823856", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of tau-protein kinase II activity"}
{"concept_id": "C3823857", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of tau-tubulin kinase activity"}
{"concept_id": "C3823858", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of TPK"}
{"concept_id": "C3823859", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of TPK I"}
{"concept_id": "C3823860", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of TPK II"}
{"concept_id": "C3823861", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of TTK"}
{"concept_id": "C3823862", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendritic spine maintenance", "definition": "Any process that modulates the frequency, rate or extent of dendritic spine maintenance. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]"}
{"concept_id": "C3823863", "aliases": ["down regulation of dendritic spine maintenance", "downregulation of dendritic spine maintenance", "down-regulation of dendritic spine maintenance"], "types": ["T043"], "canonical_name": "negative regulation of dendritic spine maintenance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic spine maintenance. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]"}
{"concept_id": "C3823864", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dendritic spine maintenance"}
{"concept_id": "C3823865", "aliases": ["upregulation of dendritic spine maintenance", "up-regulation of dendritic spine maintenance", "up regulation of dendritic spine maintenance"], "types": ["T043"], "canonical_name": "positive regulation of dendritic spine maintenance", "definition": "Any process that activates or increases the frequency, rate or extent of dendritic spine maintenance. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]"}
{"concept_id": "C3823866", "aliases": [], "types": ["T043"], "canonical_name": "activation of dendritic spine maintenance"}
{"concept_id": "C3823867", "aliases": ["up regulation of rough endoplasmic reticulum to cis-Golgi transport", "up regulation of ER to Golgi vesicle-mediated transport", "upregulation of endoplasmic reticulum to Golgi transport", "upregulation of ER to Golgi transport", "positive regulation of endoplasmic reticulum to Golgi transport", "upregulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport", "positive regulation of endoplasmic reticulum to Golgi vesicle-mediated transport", "up-regulation of ER to Golgi vesicle-mediated transport", "positive regulation of rough ER to cis-Golgi transport", "positive regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport", "up-regulation of rough ER to cis-Golgi transport", "up-regulation of ER to Golgi transport", "up-regulation of endoplasmic reticulum to Golgi vesicle-mediated transport", "up-regulation of rough ER to cis-Golgi vesicle-mediated transport", "positive regulation of ER to Golgi transport", "up regulation of endoplasmic reticulum to Golgi vesicle-mediated transport", "up regulation of rough ER to cis-Golgi vesicle-mediated transport", "upregulation of rough ER to cis-Golgi vesicle-mediated transport", "upregulation of endoplasmic reticulum to Golgi vesicle-mediated transport", "upregulation of rough endoplasmic reticulum to cis-Golgi transport", "up regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport", "up-regulation of endoplasmic reticulum to Golgi transport", "up regulation of rough ER to cis-Golgi transport", "up regulation of endoplasmic reticulum to Golgi transport", "positive regulation of rough ER to cis-Golgi vesicle-mediated transport", "up regulation of ER to Golgi transport", "up-regulation of rough endoplasmic reticulum to cis-Golgi transport", "upregulation of rough ER to cis-Golgi transport", "up-regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport", "upregulation of ER to Golgi vesicle-mediated transport", "positive regulation of rough endoplasmic reticulum to cis-Golgi transport"], "types": ["T043"], "canonical_name": "positive regulation of ER to Golgi vesicle-mediated transport", "definition": "Any process that activates or increases the frequency, rate or extent of ER to Golgi vesicle-mediated transport. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:17855360]"}
{"concept_id": "C3823868", "aliases": [], "types": ["T043"], "canonical_name": "activation of endoplasmic reticulum to Golgi transport"}
{"concept_id": "C3823869", "aliases": [], "types": ["T043"], "canonical_name": "activation of endoplasmic reticulum to Golgi vesicle-mediated transport"}
{"concept_id": "C3823870", "aliases": [], "types": ["T043"], "canonical_name": "activation of ER to Golgi transport"}
{"concept_id": "C3823871", "aliases": [], "types": ["T043"], "canonical_name": "activation of ER to Golgi vesicle-mediated transport"}
{"concept_id": "C3823872", "aliases": [], "types": ["T043"], "canonical_name": "activation of rough endoplasmic reticulum to cis-Golgi transport"}
{"concept_id": "C3823873", "aliases": [], "types": ["T043"], "canonical_name": "activation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport"}
{"concept_id": "C3823874", "aliases": [], "types": ["T043"], "canonical_name": "activation of rough ER to cis-Golgi transport"}
{"concept_id": "C3823875", "aliases": [], "types": ["T043"], "canonical_name": "activation of rough ER to cis-Golgi vesicle-mediated transport"}
{"concept_id": "C3823876", "aliases": [], "types": ["T043"], "canonical_name": "regulation of early endosome to recycling endosome transport", "definition": "Any process that modulates the frequency, rate or extent of early endosome to recycling endosome transport. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]"}
{"concept_id": "C3823877", "aliases": ["up-regulation of early endosome to recycling endosome transport", "up regulation of early endosome to recycling endosome transport", "upregulation of early endosome to recycling endosome transport"], "types": ["T043"], "canonical_name": "positive regulation of early endosome to recycling endosome transport", "definition": "Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]"}
{"concept_id": "C3823878", "aliases": [], "types": ["T043"], "canonical_name": "activation of early endosome to recycling endosome transport"}
{"concept_id": "C3823879", "aliases": ["regulation of oxidative phosphorylation, NADH to ubiquinone"], "types": ["T044"], "canonical_name": "regulation of mitochondrial electron transport, NADH to ubiquinone", "definition": "Any process that modulates the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]"}
{"concept_id": "C3823880", "aliases": [], "types": ["T044"], "canonical_name": "regulation of complex I (NADH to ubiquinone)"}
{"concept_id": "C3823881", "aliases": ["down regulation of mitochondrial electron transport, NADH to ubiquinone", "down-regulation of mitochondrial electron transport, NADH to ubiquinone", "negative regulation of oxidative phosphorylation, NADH to ubiquinone", "down regulation of oxidative phosphorylation, NADH to ubiquinone", "downregulation of oxidative phosphorylation, NADH to ubiquinone", "downregulation of mitochondrial electron transport, NADH to ubiquinone", "down-regulation of oxidative phosphorylation, NADH to ubiquinone"], "types": ["T044"], "canonical_name": "negative regulation of mitochondrial electron transport, NADH to ubiquinone", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]"}
{"concept_id": "C3823882", "aliases": ["down-regulation of complex I (NADH to ubiquinone)"], "types": ["T044"], "canonical_name": "down regulation of complex I (NADH to ubiquinone)"}
{"concept_id": "C3823883", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of complex I (NADH to ubiquinone)"}
{"concept_id": "C3823884", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of complex I (NADH to ubiquinone)"}
{"concept_id": "C3823885", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mitochondrial electron transport, NADH to ubiquinone"}
{"concept_id": "C3823886", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of oxidative phosphorylation, NADH to ubiquinone"}
{"concept_id": "C3823887", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of complex I (NADH to ubiquinone)"}
{"concept_id": "C3823888", "aliases": ["up regulation of oxidative phosphorylation, NADH to ubiquinone", "upregulation of mitochondrial electron transport, NADH to ubiquinone", "up regulation of mitochondrial electron transport, NADH to ubiquinone", "up-regulation of oxidative phosphorylation, NADH to ubiquinone", "up-regulation of mitochondrial electron transport, NADH to ubiquinone", "positive regulation of oxidative phosphorylation, NADH to ubiquinone", "upregulation of oxidative phosphorylation, NADH to ubiquinone"], "types": ["T044"], "canonical_name": "positive regulation of mitochondrial electron transport, NADH to ubiquinone", "definition": "Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]"}
{"concept_id": "C3823889", "aliases": [], "types": ["T044"], "canonical_name": "activation of complex I (NADH to ubiquinone)"}
{"concept_id": "C3823890", "aliases": [], "types": ["T044"], "canonical_name": "activation of mitochondrial electron transport, NADH to ubiquinone"}
{"concept_id": "C3823891", "aliases": [], "types": ["T044"], "canonical_name": "activation of oxidative phosphorylation, NADH to ubiquinone"}
{"concept_id": "C3823892", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of complex I (NADH to ubiquinone)"}
{"concept_id": "C3823893", "aliases": ["up-regulation of complex I (NADH to ubiquinone)"], "types": ["T044"], "canonical_name": "up regulation of complex I (NADH to ubiquinone)"}
{"concept_id": "C3823894", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of complex I (NADH to ubiquinone)"}
{"concept_id": "C3823895", "aliases": ["regulation of carboxyl protease activity involved in APP catabolic process", "regulation of aspartic-type endopeptidase activity involved in APP catabolic process", "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "regulation of aspartic protease activity involved in APP catabolic process", "regulation of aspartic protease activity involved in amyloid precursor protein catabolism", "regulation of aspartate protease activity involved in amyloid precursor protein catabolism", "regulation of aspartyl protease activity involved in amyloid precursor protein breakdown", "regulation of carboxyl protease activity involved in amyloid precursor protein breakdown", "regulation of carboxyl protease activity involved in APP catabolism", "regulation of aspartic protease activity involved in APP catabolism", "regulation of aspartyl protease activity involved in APP catabolic process", "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process", "regulation of aspartyl protease activity involved in amyloid precursor protein catabolism", "regulation of aspartic-type endopeptidase activity involved in APP catabolism", "regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation", "regulation of aspartic protease activity involved in amyloid precursor protein degradation", "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "regulation of aspartic protease activity involved in amyloid precursor protein breakdown", "regulation of aspartate protease activity involved in amyloid precursor protein degradation", "regulation of carboxyl protease activity involved in amyloid precursor protein catabolism", "regulation of aspartyl protease activity involved in APP catabolism", "regulation of aspartic endopeptidase activity involved in APP catabolic process", "regulation of aspartyl protease activity involved in amyloid precursor protein degradation", "regulation of carboxyl protease activity involved in amyloid precursor protein degradation", "regulation of aspartate protease activity involved in APP catabolism", "regulation of aspartic protease activity involved in amyloid precursor protein catabolic process", "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "regulation of aspartate protease activity involved in APP catabolic process", "regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process", "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "regulation of aspartic endopeptidase activity involved in APP catabolism", "regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process", "regulation of aspartate protease activity involved in amyloid precursor protein breakdown", "regulation of aspartate protease activity involved in amyloid precursor protein catabolic process"], "types": ["T044"], "canonical_name": "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "definition": "Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]"}
{"concept_id": "C3823896", "aliases": ["down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "negative regulation of aspartate protease activity involved in APP catabolism", "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolism", "down regulation of aspartic protease activity involved in amyloid precursor protein catabolic process", "negative regulation of carboxyl protease activity involved in APP catabolism", "down-regulation of aspartic protease activity involved in amyloid precursor protein degradation", "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "downregulation of aspartate protease activity involved in amyloid precursor protein catabolism", "negative regulation of aspartate protease activity involved in amyloid precursor protein breakdown", "down-regulation of aspartyl protease activity involved in amyloid precursor protein degradation", "down regulation of aspartic protease activity involved in APP catabolic process", "down-regulation of aspartic protease activity involved in amyloid precursor protein breakdown", "down-regulation of aspartic-type endopeptidase activity involved in APP catabolism", "down regulation of aspartate protease activity involved in amyloid precursor protein catabolism", "down regulation of aspartic endopeptidase activity involved in APP catabolic process", "downregulation of carboxyl protease activity involved in amyloid precursor protein breakdown", "downregulation of carboxyl protease activity involved in APP catabolism", "downregulation of aspartic-type endopeptidase activity involved in APP catabolism", "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolism", "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "downregulation of aspartic endopeptidase activity involved in APP catabolic process", "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "negative regulation of aspartic endopeptidase activity involved in APP catabolism", "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process", "downregulation of aspartate protease activity involved in APP catabolism", "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "down regulation of aspartic-type endopeptidase activity involved in APP catabolism", "down-regulation of carboxyl protease activity involved in APP catabolic process", "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolic process", "down-regulation of aspartate protease activity involved in APP catabolism", "down regulation of aspartate protease activity involved in amyloid precursor protein degradation", "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "down regulation of aspartic endopeptidase activity involved in APP catabolism", "down-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown", "down-regulation of aspartic protease activity involved in APP catabolism", "down regulation of aspartic-type endopeptidase activity involved in APP catabolic process", "negative regulation of aspartic-type endopeptidase activity involved in APP catabolism", "downregulation of aspartate protease activity involved in amyloid precursor protein catabolic process", "down regulation of aspartic protease activity involved in amyloid precursor protein degradation", "downregulation of aspartyl protease activity involved in amyloid precursor protein degradation", "down-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown", "negative regulation of aspartic protease activity involved in amyloid precursor protein breakdown", "down-regulation of aspartyl protease activity involved in APP catabolic process", "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "negative regulation of aspartyl protease activity involved in APP catabolic process", "down regulation of aspartate protease activity involved in APP catabolic process", "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolism", "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "down regulation of aspartyl protease activity involved in APP catabolic process", "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "negative regulation of aspartic-type endopeptidase activity involved in APP catabolic process", "downregulation of aspartyl protease activity involved in APP catabolic process", "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process", "negative regulation of aspartyl protease activity involved in APP catabolism", "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "down-regulation of carboxyl protease activity involved in APP catabolism", "down regulation of carboxyl protease activity involved in APP catabolic process", "negative regulation of aspartyl protease activity involved in amyloid precursor protein degradation", "down-regulation of aspartic protease activity involved in APP catabolic process", "negative regulation of aspartic protease activity involved in amyloid precursor protein degradation", "downregulation of aspartate protease activity involved in amyloid precursor protein breakdown", "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation", "down regulation of aspartate protease activity involved in amyloid precursor protein breakdown", "downregulation of aspartic protease activity involved in amyloid precursor protein breakdown", "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process", "down-regulation of aspartic endopeptidase activity involved in APP catabolic process", "down-regulation of aspartyl protease activity involved in APP catabolism", "negative regulation of carboxyl protease activity involved in amyloid precursor protein degradation", "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process", "downregulation of aspartate protease activity involved in amyloid precursor protein degradation", "down regulation of aspartic protease activity involved in APP catabolism", "downregulation of aspartic protease activity involved in APP catabolic process", "down-regulation of aspartate protease activity involved in amyloid precursor protein degradation", "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolism", "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolism", "down-regulation of carboxyl protease activity involved in amyloid precursor protein degradation", "downregulation of aspartic protease activity involved in amyloid precursor protein catabolism", "downregulation of carboxyl protease activity involved in APP catabolic process", "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "down regulation of carboxyl protease activity involved in amyloid precursor protein breakdown", "down regulation of aspartate protease activity involved in APP catabolism", "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process", "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process", "negative regulation of carboxyl protease activity involved in APP catabolic process", "negative regulation of aspartic protease activity involved in APP catabolism", "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation", "down-regulation of aspartic-type endopeptidase activity involved in APP catabolic process", "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process", "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolism", "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation", "negative regulation of aspartyl protease activity involved in amyloid precursor protein breakdown", "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process", "downregulation of aspartic-type endopeptidase activity involved in APP catabolic process", "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolism", "negative regulation of carboxyl protease activity involved in amyloid precursor protein breakdown", "negative regulation of aspartate protease activity involved in APP catabolic process", "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism", "negative regulation of aspartate protease activity involved in amyloid precursor protein degradation", "downregulation of aspartic endopeptidase activity involved in APP catabolism", "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism", "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process", "downregulation of aspartyl protease activity involved in APP catabolism", "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolism", "down-regulation of aspartate protease activity involved in amyloid precursor protein breakdown", "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process", "down regulation of aspartate protease activity involved in amyloid precursor protein catabolic process", "negative regulation of aspartic protease activity involved in APP catabolic process", "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolism", "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation", "downregulation of aspartic protease activity involved in amyloid precursor protein degradation", "down regulation of aspartic protease activity involved in amyloid precursor protein catabolism", "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process", "downregulation of aspartyl protease activity involved in amyloid precursor protein breakdown", "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process", "downregulation of aspartate protease activity involved in APP catabolic process", "downregulation of aspartic protease activity involved in amyloid precursor protein catabolic process", "down regulation of aspartyl protease activity involved in APP catabolism", "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolic process", "down regulation of carboxyl protease activity involved in amyloid precursor protein degradation", "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "down-regulation of aspartate protease activity involved in APP catabolic process", "down regulation of aspartyl protease activity involved in amyloid precursor protein degradation", "down regulation of aspartic protease activity involved in amyloid precursor protein breakdown", "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process", "downregulation of carboxyl protease activity involved in amyloid precursor protein degradation", "down-regulation of aspartic endopeptidase activity involved in APP catabolism", "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process", "down regulation of carboxyl protease activity involved in APP catabolism", "negative regulation of aspartic endopeptidase activity involved in APP catabolic process", "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolism", "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "down regulation of aspartyl protease activity involved in amyloid precursor protein breakdown", "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "downregulation of aspartic protease activity involved in APP catabolism"], "types": ["T044"], "canonical_name": "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]"}
{"concept_id": "C3823897", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartate protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823898", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartate protease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823899", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartate protease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823900", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartate protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823901", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartate protease activity involved in APP catabolic process"}
{"concept_id": "C3823902", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartate protease activity involved in APP catabolism"}
{"concept_id": "C3823903", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823904", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823905", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823906", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823907", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic endopeptidase activity involved in APP catabolic process"}
{"concept_id": "C3823908", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic endopeptidase activity involved in APP catabolism"}
{"concept_id": "C3823909", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823910", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic protease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823911", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic protease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823912", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823913", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic protease activity involved in APP catabolic process"}
{"concept_id": "C3823914", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic protease activity involved in APP catabolism"}
{"concept_id": "C3823915", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823916", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823917", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823918", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823919", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic-type endopeptidase activity involved in APP catabolic process"}
{"concept_id": "C3823920", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic-type endopeptidase activity involved in APP catabolism"}
{"concept_id": "C3823921", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartyl protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823922", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823923", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823924", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartyl protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823925", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartyl protease activity involved in APP catabolic process"}
{"concept_id": "C3823926", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartyl protease activity involved in APP catabolism"}
{"concept_id": "C3823927", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carboxyl protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823928", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823929", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823930", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carboxyl protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823931", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carboxyl protease activity involved in APP catabolic process"}
{"concept_id": "C3823932", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carboxyl protease activity involved in APP catabolism"}
{"concept_id": "C3823933", "aliases": ["up-regulation of aspartic endopeptidase activity involved in APP catabolism", "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process", "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation", "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "upregulation of aspartic protease activity involved in APP catabolic process", "positive regulation of carboxyl protease activity involved in amyloid precursor protein breakdown", "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolism", "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "positive regulation of aspartic protease activity involved in APP catabolism", "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolism", "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism", "up regulation of aspartic protease activity involved in amyloid precursor protein degradation", "up regulation of carboxyl protease activity involved in APP catabolism", "positive regulation of carboxyl protease activity involved in APP catabolic process", "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process", "positive regulation of aspartate protease activity involved in amyloid precursor protein breakdown", "up regulation of aspartic protease activity involved in APP catabolic process", "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process", "up regulation of aspartate protease activity involved in amyloid precursor protein catabolic process", "up-regulation of aspartic protease activity involved in amyloid precursor protein degradation", "upregulation of aspartate protease activity involved in amyloid precursor protein breakdown", "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolism", "upregulation of carboxyl protease activity involved in APP catabolism", "positive regulation of carboxyl protease activity involved in amyloid precursor protein degradation", "up regulation of aspartic protease activity involved in APP catabolism", "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "up regulation of aspartic-type endopeptidase activity involved in APP catabolism", "upregulation of aspartyl protease activity involved in APP catabolic process", "upregulation of aspartic protease activity involved in amyloid precursor protein catabolism", "up-regulation of aspartyl protease activity involved in APP catabolic process", "up regulation of aspartic-type endopeptidase activity involved in APP catabolic process", "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process", "positive regulation of aspartate protease activity involved in APP catabolism", "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolic process", "positive regulation of aspartic endopeptidase activity involved in APP catabolic process", "positive regulation of aspartic protease activity involved in amyloid precursor protein degradation", "positive regulation of aspartyl protease activity involved in APP catabolism", "up-regulation of aspartic protease activity involved in APP catabolic process", "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "upregulation of aspartyl protease activity involved in amyloid precursor protein degradation", "up-regulation of aspartic endopeptidase activity involved in APP catabolic process", "up regulation of aspartate protease activity involved in amyloid precursor protein breakdown", "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process", "up regulation of aspartate protease activity involved in amyloid precursor protein catabolism", "up-regulation of aspartate protease activity involved in amyloid precursor protein degradation", "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process", "upregulation of aspartic protease activity involved in amyloid precursor protein catabolic process", "upregulation of aspartate protease activity involved in amyloid precursor protein degradation", "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process", "positive regulation of aspartyl protease activity involved in amyloid precursor protein degradation", "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "positive regulation of aspartate protease activity involved in amyloid precursor protein degradation", "up-regulation of aspartyl protease activity involved in APP catabolism", "upregulation of aspartic endopeptidase activity involved in APP catabolic process", "positive regulation of aspartyl protease activity involved in APP catabolic process", "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "upregulation of carboxyl protease activity involved in amyloid precursor protein breakdown", "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process", "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolism", "up-regulation of aspartic-type endopeptidase activity involved in APP catabolism", "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation", "up-regulation of carboxyl protease activity involved in amyloid precursor protein degradation", "up regulation of aspartyl protease activity involved in amyloid precursor protein degradation", "up-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown", "up regulation of aspartyl protease activity involved in APP catabolic process", "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation", "positive regulation of aspartic-type endopeptidase activity involved in APP catabolic process", "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "up regulation of aspartic endopeptidase activity involved in APP catabolism", "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism", "up-regulation of carboxyl protease activity involved in APP catabolic process", "up regulation of carboxyl protease activity involved in amyloid precursor protein breakdown", "positive regulation of aspartyl protease activity involved in amyloid precursor protein breakdown", "up regulation of aspartic protease activity involved in amyloid precursor protein catabolic process", "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process", "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolism", "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process", "up-regulation of aspartate protease activity involved in amyloid precursor protein breakdown", "upregulation of aspartic protease activity involved in amyloid precursor protein breakdown", "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "upregulation of aspartate protease activity involved in amyloid precursor protein catabolic process", "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process", "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolism", "up regulation of aspartyl protease activity involved in APP catabolism", "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "up-regulation of aspartyl protease activity involved in amyloid precursor protein degradation", "positive regulation of aspartic-type endopeptidase activity involved in APP catabolism", "up-regulation of aspartic protease activity involved in amyloid precursor protein breakdown", "up regulation of aspartate protease activity involved in amyloid precursor protein degradation", "up regulation of carboxyl protease activity involved in amyloid precursor protein degradation", "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "up-regulation of aspartate protease activity involved in APP catabolism", "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolism", "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolism", "up regulation of aspartic protease activity involved in amyloid precursor protein breakdown", "up regulation of aspartyl protease activity involved in amyloid precursor protein breakdown", "upregulation of aspartic protease activity involved in amyloid precursor protein degradation", "upregulation of aspartate protease activity involved in APP catabolism", "upregulation of aspartate protease activity involved in APP catabolic process", "upregulation of aspartate protease activity involved in amyloid precursor protein catabolism", "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process", "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process", "up-regulation of aspartic protease activity involved in APP catabolism", "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation", "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown", "positive regulation of aspartic protease activity involved in amyloid precursor protein breakdown", "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism", "upregulation of aspartic-type endopeptidase activity involved in APP catabolism", "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "upregulation of carboxyl protease activity involved in amyloid precursor protein degradation", "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolism", "upregulation of aspartyl protease activity involved in APP catabolism", "up-regulation of carboxyl protease activity involved in APP catabolism", "upregulation of aspartic-type endopeptidase activity involved in APP catabolic process", "upregulation of aspartyl protease activity involved in amyloid precursor protein breakdown", "up regulation of aspartate protease activity involved in APP catabolic process", "up regulation of aspartic protease activity involved in amyloid precursor protein catabolism", "up-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown", "upregulation of aspartic endopeptidase activity involved in APP catabolism", "up regulation of carboxyl protease activity involved in APP catabolic process", "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown", "upregulation of aspartic protease activity involved in APP catabolism", "up regulation of aspartic endopeptidase activity involved in APP catabolic process", "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation", "positive regulation of aspartic endopeptidase activity involved in APP catabolism", "up regulation of aspartate protease activity involved in APP catabolism", "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolic process", "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process", "up-regulation of aspartate protease activity involved in APP catabolic process", "up-regulation of aspartic-type endopeptidase activity involved in APP catabolic process", "positive regulation of aspartate protease activity involved in APP catabolic process", "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism", "upregulation of carboxyl protease activity involved in APP catabolic process", "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolism", "positive regulation of aspartic protease activity involved in APP catabolic process", "positive regulation of carboxyl protease activity involved in APP catabolism"], "types": ["T044"], "canonical_name": "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]"}
{"concept_id": "C3823934", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartate protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823935", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartate protease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823936", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartate protease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823937", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartate protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823938", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartate protease activity involved in APP catabolic process"}
{"concept_id": "C3823939", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartate protease activity involved in APP catabolism"}
{"concept_id": "C3823940", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823941", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823942", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823943", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic endopeptidase activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823944", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic endopeptidase activity involved in APP catabolic process"}
{"concept_id": "C3823945", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic endopeptidase activity involved in APP catabolism"}
{"concept_id": "C3823946", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823947", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic protease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823948", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic protease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823949", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823950", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic protease activity involved in APP catabolic process"}
{"concept_id": "C3823951", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic protease activity involved in APP catabolism"}
{"concept_id": "C3823952", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823953", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823954", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823955", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823956", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic-type endopeptidase activity involved in APP catabolic process"}
{"concept_id": "C3823957", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic-type endopeptidase activity involved in APP catabolism"}
{"concept_id": "C3823958", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartyl protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823959", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartyl protease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823960", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartyl protease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823961", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartyl protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823962", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartyl protease activity involved in APP catabolic process"}
{"concept_id": "C3823963", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartyl protease activity involved in APP catabolism"}
{"concept_id": "C3823964", "aliases": [], "types": ["T044"], "canonical_name": "activation of carboxyl protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823965", "aliases": [], "types": ["T044"], "canonical_name": "activation of carboxyl protease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823966", "aliases": [], "types": ["T044"], "canonical_name": "activation of carboxyl protease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823967", "aliases": [], "types": ["T044"], "canonical_name": "activation of carboxyl protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823968", "aliases": [], "types": ["T044"], "canonical_name": "activation of carboxyl protease activity involved in APP catabolic process"}
{"concept_id": "C3823969", "aliases": [], "types": ["T044"], "canonical_name": "activation of carboxyl protease activity involved in APP catabolism"}
{"concept_id": "C3823970", "aliases": ["regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism", "regulation of metalloendoproteinase activity involved in APP catabolic process", "regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown", "regulation of metalloendopeptidase activity involved in APP catabolic process", "regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown", "regulation of metalloendoprotease activity involved in APP catabolic process", "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "regulation of metalloendoprotease activity involved in APP catabolism", "regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation", "regulation of metalloendoprotease activity involved in amyloid precursor protein degradation", "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism", "regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown", "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process", "regulation of metalloendopeptidase activity involved in APP catabolism", "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism", "regulation of metalloendoproteinase activity involved in APP catabolism", "regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation"], "types": ["T044"], "canonical_name": "regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "definition": "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153]"}
{"concept_id": "C3823971", "aliases": ["down regulation of metalloendopeptidase activity involved in APP catabolism", "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism", "down-regulation of metalloendopeptidase activity involved in APP catabolic process", "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism", "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "negative regulation of metalloendoproteinase activity involved in APP catabolism", "down regulation of metalloendoprotease activity involved in amyloid precursor protein degradation", "downregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation", "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism", "down-regulation of metalloendopeptidase activity involved in APP catabolism", "down-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown", "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism", "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism", "downregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown", "down regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown", "down regulation of metalloendoproteinase activity involved in APP catabolic process", "negative regulation of metalloendoproteinase activity involved in APP catabolic process", "negative regulation of metalloendoprotease activity involved in amyloid precursor protein degradation", "down regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation", "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown", "down-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation", "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism", "down regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown", "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "downregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation", "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism", "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown", "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation", "negative regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown", "downregulation of metalloendopeptidase activity involved in APP catabolic process", "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown", "down regulation of metalloendoprotease activity involved in APP catabolic process", "downregulation of metalloendoprotease activity involved in APP catabolism", "down-regulation of metalloendoprotease activity involved in APP catabolic process", "downregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown", "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism", "down-regulation of metalloendoproteinase activity involved in APP catabolic process", "downregulation of metalloendopeptidase activity involved in APP catabolism", "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism", "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism", "down-regulation of metalloendoproteinase activity involved in APP catabolism", "downregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown", "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process", "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation", "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism", "down regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation", "negative regulation of metalloendopeptidase activity involved in APP catabolism", "negative regulation of metalloendoprotease activity involved in APP catabolic process", "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "negative regulation of metalloendopeptidase activity involved in APP catabolic process", "negative regulation of metalloendoprotease activity involved in APP catabolism", "downregulation of metalloendoproteinase activity involved in APP catabolism", "down regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown", "downregulation of metalloendoprotease activity involved in amyloid precursor protein degradation", "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism", "downregulation of metalloendoproteinase activity involved in APP catabolic process", "down regulation of metalloendoproteinase activity involved in APP catabolism", "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation", "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation", "down regulation of metalloendoprotease activity involved in APP catabolism", "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown", "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process", "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "down-regulation of metalloendoprotease activity involved in APP catabolism", "downregulation of metalloendoprotease activity involved in APP catabolic process", "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process", "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process", "down regulation of metalloendopeptidase activity involved in APP catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153]"}
{"concept_id": "C3823972", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendopeptidase activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823973", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823974", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823975", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendopeptidase activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823976", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendopeptidase activity involved in APP catabolic process"}
{"concept_id": "C3823977", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendopeptidase activity involved in APP catabolism"}
{"concept_id": "C3823978", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoprotease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823979", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823980", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823981", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoprotease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823982", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoprotease activity involved in APP catabolic process"}
{"concept_id": "C3823983", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoprotease activity involved in APP catabolism"}
{"concept_id": "C3823984", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoproteinase activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823985", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823986", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823987", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoproteinase activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823988", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoproteinase activity involved in APP catabolic process"}
{"concept_id": "C3823989", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoproteinase activity involved in APP catabolism"}
{"concept_id": "C3823990", "aliases": ["positive regulation of metalloendoproteinase activity involved in APP catabolic process", "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation", "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism", "positive regulation of metalloendoprotease activity involved in APP catabolic process", "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "up regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation", "positive regulation of metalloendoproteinase activity involved in APP catabolism", "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism", "upregulation of metalloendoproteinase activity involved in APP catabolic process", "up regulation of metalloendoproteinase activity involved in APP catabolism", "upregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation", "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism", "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation", "up-regulation of metalloendoprotease activity involved in APP catabolic process", "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation", "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown", "up regulation of metalloendoprotease activity involved in amyloid precursor protein degradation", "up regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown", "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism", "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism", "up regulation of metalloendopeptidase activity involved in APP catabolism", "up-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation", "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown", "upregulation of metalloendoproteinase activity involved in APP catabolism", "positive regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown", "up regulation of metalloendoprotease activity involved in APP catabolism", "upregulation of metalloendoprotease activity involved in APP catabolism", "upregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown", "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation", "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process", "upregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown", "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process", "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "up-regulation of metalloendoproteinase activity involved in APP catabolic process", "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "positive regulation of metalloendopeptidase activity involved in APP catabolism", "upregulation of metalloendopeptidase activity involved in APP catabolism", "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism", "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism", "up-regulation of metalloendoprotease activity involved in APP catabolism", "up regulation of metalloendoproteinase activity involved in APP catabolic process", "up-regulation of metalloendopeptidase activity involved in APP catabolic process", "positive regulation of metalloendoprotease activity involved in APP catabolism", "positive regulation of metalloendopeptidase activity involved in APP catabolic process", "upregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown", "up-regulation of metalloendoproteinase activity involved in APP catabolism", "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "upregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation", "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism", "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "up regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation", "up regulation of metalloendoprotease activity involved in APP catabolic process", "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism", "up regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown", "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process", "up regulation of metalloendopeptidase activity involved in APP catabolic process", "positive regulation of metalloendoprotease activity involved in amyloid precursor protein degradation", "upregulation of metalloendopeptidase activity involved in APP catabolic process", "upregulation of metalloendoprotease activity involved in APP catabolic process", "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism", "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism", "up regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown", "up-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown", "upregulation of metalloendoprotease activity involved in amyloid precursor protein degradation", "up-regulation of metalloendopeptidase activity involved in APP catabolism", "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown", "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown", "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process", "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism"], "types": ["T044"], "canonical_name": "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153]"}
{"concept_id": "C3823991", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendopeptidase activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823992", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823993", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3823994", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendopeptidase activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3823995", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendopeptidase activity involved in APP catabolic process"}
{"concept_id": "C3823996", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendopeptidase activity involved in APP catabolism"}
{"concept_id": "C3823997", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoprotease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3823998", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoprotease activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3823999", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoprotease activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3824000", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoprotease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3824001", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoprotease activity involved in APP catabolic process"}
{"concept_id": "C3824002", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoprotease activity involved in APP catabolism"}
{"concept_id": "C3824003", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoproteinase activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C3824004", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process"}
{"concept_id": "C3824005", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolism"}
{"concept_id": "C3824006", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoproteinase activity involved in amyloid precursor protein degradation"}
{"concept_id": "C3824007", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoproteinase activity involved in APP catabolic process"}
{"concept_id": "C3824008", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoproteinase activity involved in APP catabolism"}
{"concept_id": "C3824009", "aliases": ["regulation of protein localisation to early endosome", "regulation of protein localization in early endosome", "regulation of protein localisation in early endosome"], "types": ["T039"], "canonical_name": "regulation of protein localization to early endosome", "definition": "Any process that modulates the frequency, rate or extent of protein localization to early endosome. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]"}
{"concept_id": "C3824010", "aliases": ["positive regulation of protein localisation in early endosome", "up regulation of protein localization in early endosome", "upregulation of protein localization to early endosome", "up-regulation of protein localization to early endosome", "upregulation of protein localisation to early endosome", "up regulation of protein localization to early endosome", "up-regulation of protein localisation in early endosome", "up regulation of protein localisation in early endosome", "positive regulation of protein localization in early endosome", "up-regulation of protein localisation to early endosome", "positive regulation of protein localisation to early endosome", "upregulation of protein localization in early endosome", "up regulation of protein localisation to early endosome", "up-regulation of protein localization in early endosome", "upregulation of protein localisation in early endosome"], "types": ["T039"], "canonical_name": "positive regulation of protein localization to early endosome", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to early endosome. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]"}
{"concept_id": "C3824011", "aliases": ["activation of protein localization in early endosome", "activation of protein localization to early endosome", "activation of protein localisation to early endosome"], "types": ["T039"], "canonical_name": "activation of protein localisation in early endosome"}
{"concept_id": "C3824012", "aliases": ["protein localisation to mitotic spindle midzone", "protein localisation in mitotic spindle midzone", "protein localization in mitotic spindle midzone"], "types": ["T043"], "canonical_name": "protein localization to mitotic spindle midzone", "definition": "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle midzone. [GO_REF:0000087, GOC:TermGenie, PMID:16824200]"}
{"concept_id": "C3824014", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication during S phase involved in meiotic cell cycle"}
{"concept_id": "C3824015", "aliases": ["DNA replication involved in S phase involved in mitotic cell cycle", "DNA replication involved in S-phase involved in mitotic cell cycle", "mitotic cell cycle DNA replication", "mitotic nuclear cell cycle DNA replication"], "types": ["T045"], "canonical_name": "mitotic DNA replication", "definition": "Any nuclear DNA replication that is involved in a mitotic cell cycle. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824016", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication during S phase involved in mitotic cell cycle"}
{"concept_id": "C3824017", "aliases": [], "types": ["T045"], "canonical_name": "nuclear cell cycle DNA replication involved in mitotic cell cycle"}
{"concept_id": "C3824018", "aliases": ["DNA duplex unwinding involved in meiotic DNA replication", "DNA duplex unwinding involved in meiotic cell cycle DNA replication"], "types": ["T043"], "canonical_name": "premeiotic DNA replication DNA duplex unwinding", "definition": "Any DNA duplex unwinding involved in meiotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824019", "aliases": ["DNA duplex unwinding involved in mitotic DNA replication", "DNA duplex unwinding involved in mitotic cell cycle DNA replication"], "types": ["T045"], "canonical_name": "mitotic DNA replication DNA duplex unwinding", "definition": "Any DNA duplex unwinding involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824020", "aliases": ["DNA ligation involved in meiotic DNA replication"], "types": ["T043"], "canonical_name": "premeiotic DNA replication DNA ligation", "definition": "Any DNA ligation involved in meiotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824021", "aliases": [], "types": ["T043"], "canonical_name": "DNA ligation involved in meiotic cell cycle DNA replication"}
{"concept_id": "C3824022", "aliases": ["DNA ligation involved in mitotic cell cycle DNA replication", "DNA ligation involved in mitotic DNA replication"], "types": ["T045"], "canonical_name": "mitotic DNA replication DNA ligation", "definition": "Any DNA ligation involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824024", "aliases": ["DNA replication initiation involved in mitotic cell cycle DNA replication"], "types": ["T045"], "canonical_name": "mitotic DNA replication initiation", "definition": "Any DNA replication initiation involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824025", "aliases": ["DNA replication preinitiation complex formation involved in meiotic cell cycle", "pre-IC complex assembly involved in meiotic cell cycle"], "types": ["T044"], "canonical_name": "premeiotic DNA replication preinitiation complex assembly", "definition": "Any DNA replication preinitiation complex assembly that is involved in meiotic cell cycle. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824026", "aliases": ["pre-IC complex assembly involved in mitotic cell cycle", "DNA replication preinitiation complex formation involved in mitotic cell cycle"], "types": ["T044"], "canonical_name": "mitotic DNA replication preinitiation complex assembly", "definition": "Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824027", "aliases": ["DNA replication termination involved in meiotic cell cycle DNA replication", "DNA replication termination involved in meiotic DNA replication"], "types": ["T043"], "canonical_name": "premeiotic DNA replication termination", "definition": "Any DNA replication termination involved in meiotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824028", "aliases": ["DNA replication termination involved in mitotic cell cycle DNA replication"], "types": ["T045"], "canonical_name": "mitotic DNA replication termination", "definition": "Any DNA replication termination involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824029", "aliases": ["synthesis of RNA primer involved in meiotic cell cycle DNA replication"], "types": ["T043"], "canonical_name": "synthesis of RNA primer involved in premeiotic DNA replication", "definition": "Any synthesis of RNA primer involved in meiotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824030", "aliases": ["synthesis of RNA primer involved in mitotic cell cycle DNA replication"], "types": ["T045"], "canonical_name": "synthesis of RNA primer involved in mitotic DNA replication", "definition": "Any synthesis of RNA primer involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824031", "aliases": ["DNA strand elongation involved in meiotic cell cycle DNA replication"], "types": ["T043"], "canonical_name": "DNA strand elongation involved in premeiotic DNA replication", "definition": "Any DNA strand elongation involved in meiotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824032", "aliases": ["DNA strand elongation involved in mitotic cell cycle DNA replication"], "types": ["T045"], "canonical_name": "DNA strand elongation involved in mitotic DNA replication", "definition": "Any DNA strand elongation involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824033", "aliases": ["pre-replicative complex assembly involved in meiotic cell cycle DNA replication", "nuclear pre-replicative complex assembly involved in meiotic cell cycle"], "types": ["T044"], "canonical_name": "pre-replicative complex assembly involved in premeiotic DNA replication", "definition": "Any pre-replicative complex assembly involved in meiotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824034", "aliases": [], "types": ["T044"], "canonical_name": "pre-RC complex assembly involved in meiosis"}
{"concept_id": "C3824035", "aliases": [], "types": ["T044"], "canonical_name": "pre-replicative complex assembly involved in meiosis"}
{"concept_id": "C3824036", "aliases": [], "types": ["T044"], "canonical_name": "pre-replicative complex formation involved in meiosis"}
{"concept_id": "C3824037", "aliases": ["pre-replicative complex assembly involved in mitotic cell cycle DNA replication", "nuclear pre-replicative complex assembly involved in mitotic cell cycle"], "types": ["T044"], "canonical_name": "mitotic pre-replicative complex assembly", "definition": "Any pre-replicative complex assembly involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824038", "aliases": ["regulation of lysine formation via aminoadipic acid", "regulation of lysine biosynthetic process, aminoadipic acid pathway", "regulation of lysine biosynthesis, aminoadipic pathway", "regulation of lysine biosynthesis, aminoadipic acid pathway", "regulation of lysine biosynthetic process, aminoadipic pathway", "regulation of lysine anabolism via aminoadipic acid", "regulation of lysine synthesis via aminoadipic acid"], "types": ["T044"], "canonical_name": "regulation of lysine biosynthetic process via aminoadipic acid", "definition": "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid. [GO_REF:0000058, GOC:TermGenie, PMID:8590464]"}
{"concept_id": "C3824039", "aliases": ["downregulation of lysine formation via aminoadipic acid", "down-regulation of lysine formation via aminoadipic acid", "down-regulation of lysine biosynthetic process via aminoadipic acid", "downregulation of lysine biosynthetic process via aminoadipic acid", "downregulation of lysine anabolism via aminoadipic acid", "down regulation of lysine biosynthesis, aminoadipic pathway", "negative regulation of lysine biosynthesis, aminoadipic acid pathway", "down-regulation of lysine synthesis via aminoadipic acid", "down regulation of lysine biosynthetic process, aminoadipic pathway", "down regulation of lysine biosynthetic process, aminoadipic acid pathway", "down regulation of lysine biosynthesis, aminoadipic acid pathway", "down-regulation of lysine biosynthesis, aminoadipic acid pathway", "downregulation of lysine synthesis via aminoadipic acid", "down regulation of lysine formation via aminoadipic acid", "negative regulation of lysine biosynthetic process, aminoadipic acid pathway", "down regulation of lysine biosynthetic process via aminoadipic acid", "down-regulation of lysine biosynthesis, aminoadipic pathway", "down-regulation of lysine anabolism via aminoadipic acid", "negative regulation of lysine anabolism via aminoadipic acid", "down-regulation of lysine biosynthetic process, aminoadipic acid pathway", "down regulation of lysine anabolism via aminoadipic acid", "downregulation of lysine biosynthetic process, aminoadipic acid pathway", "negative regulation of lysine biosynthetic process, aminoadipic pathway", "downregulation of lysine biosynthetic process, aminoadipic pathway", "down-regulation of lysine biosynthetic process, aminoadipic pathway", "negative regulation of lysine synthesis via aminoadipic acid", "negative regulation of lysine formation via aminoadipic acid", "downregulation of lysine biosynthesis, aminoadipic acid pathway", "down regulation of lysine synthesis via aminoadipic acid", "negative regulation of lysine biosynthesis, aminoadipic pathway", "downregulation of lysine biosynthesis, aminoadipic pathway"], "types": ["T044"], "canonical_name": "negative regulation of lysine biosynthetic process via aminoadipic acid", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid. [GO_REF:0000058, GOC:TermGenie, PMID:8590464]"}
{"concept_id": "C3824040", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysine anabolism via aminoadipic acid"}
{"concept_id": "C3824041", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysine biosynthesis, aminoadipic acid pathway"}
{"concept_id": "C3824042", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysine biosynthesis, aminoadipic pathway"}
{"concept_id": "C3824043", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysine biosynthetic process via aminoadipic acid"}
{"concept_id": "C3824044", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysine biosynthetic process, aminoadipic acid pathway"}
{"concept_id": "C3824045", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysine biosynthetic process, aminoadipic pathway"}
{"concept_id": "C3824046", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysine formation via aminoadipic acid"}
{"concept_id": "C3824047", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysine synthesis via aminoadipic acid"}
{"concept_id": "C3824048", "aliases": ["neurofibrillary tangle formation"], "types": ["T043"], "canonical_name": "neurofibrillary tangle assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle. [GO_REF:0000079, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780, PMID:24154541]"}
{"concept_id": "C3824049", "aliases": [], "types": ["T043"], "canonical_name": "flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824050", "aliases": [], "types": ["T043"], "canonical_name": "flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824051", "aliases": [], "types": ["T043"], "canonical_name": "star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824052", "aliases": [], "types": ["T043"], "canonical_name": "star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824053", "aliases": [], "types": ["T045"], "canonical_name": "meiotic telomere maintenance via semi-conservative replication", "definition": "Any telomere maintenance via semi-conservative replication that is involved in meiotic cell cycle. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824054", "aliases": [], "types": ["T045"], "canonical_name": "equal telomere replication involved in meiotic cell cycle"}
{"concept_id": "C3824055", "aliases": [], "types": ["T045"], "canonical_name": "telomeric fork progression involved in meiotic cell cycle"}
{"concept_id": "C3824056", "aliases": [], "types": ["T045"], "canonical_name": "telomeric replication fork progression involved in meiotic cell cycle"}
{"concept_id": "C3824057", "aliases": [], "types": ["T045"], "canonical_name": "mitotic telomere maintenance via semi-conservative replication", "definition": "Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle. [GO_REF:0000060, GOC:TermGenie]"}
{"concept_id": "C3824058", "aliases": [], "types": ["T045"], "canonical_name": "equal telomere replication involved in mitotic cell cycle"}
{"concept_id": "C3824059", "aliases": [], "types": ["T045"], "canonical_name": "telomeric fork progression involved in mitotic cell cycle"}
{"concept_id": "C3824060", "aliases": [], "types": ["T045"], "canonical_name": "telomeric replication fork progression involved in mitotic cell cycle"}
{"concept_id": "C3824061", "aliases": ["regulation of APP catabolism", "regulation of amyloid precursor protein breakdown", "regulation of amyloid precursor protein catabolism", "regulation of APP catabolic process", "regulation of amyloid precursor protein degradation"], "types": ["T044"], "canonical_name": "regulation of amyloid precursor protein catabolic process", "definition": "Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]"}
{"concept_id": "C3824062", "aliases": ["down regulation of APP catabolic process", "negative regulation of APP catabolism", "downregulation of APP catabolism", "negative regulation of amyloid precursor protein catabolism", "down regulation of amyloid precursor protein breakdown", "downregulation of amyloid precursor protein breakdown", "negative regulation of amyloid precursor protein degradation", "downregulation of APP catabolic process", "down-regulation of amyloid precursor protein catabolism", "down regulation of amyloid precursor protein catabolic process", "down regulation of amyloid precursor protein degradation", "downregulation of amyloid precursor protein catabolism", "down-regulation of APP catabolic process", "down-regulation of amyloid precursor protein breakdown", "down regulation of APP catabolism", "negative regulation of amyloid precursor protein breakdown", "downregulation of amyloid precursor protein catabolic process", "down-regulation of amyloid precursor protein catabolic process", "down-regulation of amyloid precursor protein degradation", "negative regulation of APP catabolic process", "down regulation of amyloid precursor protein catabolism", "down-regulation of APP catabolism", "downregulation of amyloid precursor protein degradation"], "types": ["T044"], "canonical_name": "negative regulation of amyloid precursor protein catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]"}
{"concept_id": "C3824063", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amyloid precursor protein breakdown"}
{"concept_id": "C3824064", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amyloid precursor protein catabolic process"}
{"concept_id": "C3824065", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amyloid precursor protein catabolism"}
{"concept_id": "C3824066", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amyloid precursor protein degradation"}
{"concept_id": "C3824067", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of APP catabolic process"}
{"concept_id": "C3824068", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of APP catabolism"}
{"concept_id": "C3824069", "aliases": ["up-regulation of amyloid precursor protein degradation", "upregulation of amyloid precursor protein degradation", "upregulation of amyloid precursor protein catabolism", "up-regulation of APP catabolic process", "positive regulation of amyloid precursor protein catabolism", "upregulation of APP catabolic process", "up-regulation of APP catabolism", "positive regulation of amyloid precursor protein degradation", "up regulation of amyloid precursor protein catabolism", "up-regulation of amyloid precursor protein catabolic process", "positive regulation of amyloid precursor protein breakdown", "up regulation of amyloid precursor protein breakdown", "positive regulation of APP catabolic process", "up regulation of APP catabolism", "upregulation of APP catabolism", "upregulation of amyloid precursor protein breakdown", "upregulation of amyloid precursor protein catabolic process", "up regulation of amyloid precursor protein catabolic process", "up-regulation of amyloid precursor protein catabolism", "up regulation of APP catabolic process", "positive regulation of APP catabolism", "up-regulation of amyloid precursor protein breakdown", "up regulation of amyloid precursor protein degradation"], "types": ["T044"], "canonical_name": "positive regulation of amyloid precursor protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]"}
{"concept_id": "C3824070", "aliases": [], "types": ["T044"], "canonical_name": "activation of amyloid precursor protein breakdown"}
{"concept_id": "C3824071", "aliases": [], "types": ["T044"], "canonical_name": "activation of amyloid precursor protein catabolic process"}
{"concept_id": "C3824072", "aliases": [], "types": ["T044"], "canonical_name": "activation of amyloid precursor protein catabolism"}
{"concept_id": "C3824073", "aliases": [], "types": ["T044"], "canonical_name": "activation of amyloid precursor protein degradation"}
{"concept_id": "C3824074", "aliases": [], "types": ["T044"], "canonical_name": "activation of APP catabolic process"}
{"concept_id": "C3824075", "aliases": [], "types": ["T044"], "canonical_name": "activation of APP catabolism"}
{"concept_id": "C3824076", "aliases": ["regulation of phospholipid export"], "types": ["T044"], "canonical_name": "regulation of phospholipid efflux", "definition": "Any process that modulates the frequency, rate or extent of phospholipid efflux. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316]"}
{"concept_id": "C3824077", "aliases": ["up-regulation of phospholipid efflux", "up regulation of phospholipid export", "up regulation of phospholipid efflux", "positive regulation of phospholipid export", "upregulation of phospholipid efflux", "up-regulation of phospholipid export", "upregulation of phospholipid export"], "types": ["T044"], "canonical_name": "positive regulation of phospholipid efflux", "definition": "Any process that activates or increases the frequency, rate or extent of phospholipid efflux. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316]"}
{"concept_id": "C3824078", "aliases": [], "types": ["T044"], "canonical_name": "activation of phospholipid efflux"}
{"concept_id": "C3824079", "aliases": [], "types": ["T044"], "canonical_name": "activation of phospholipid export"}
{"concept_id": "C3824080", "aliases": ["regulation of neurofibrillary tangle formation"], "types": ["T043"], "canonical_name": "regulation of neurofibrillary tangle assembly", "definition": "Any process that modulates the frequency, rate or extent of neurofibrillary tangle assembly. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157]"}
{"concept_id": "C3824081", "aliases": [], "types": ["T043"], "canonical_name": "regulation of flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824082", "aliases": [], "types": ["T043"], "canonical_name": "regulation of star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824083", "aliases": [], "types": ["T043"], "canonical_name": "regulation of star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824084", "aliases": ["down regulation of neurofibrillary tangle assembly", "downregulation of neurofibrillary tangle assembly", "down-regulation of neurofibrillary tangle assembly", "downregulation of neurofibrillary tangle formation", "down-regulation of neurofibrillary tangle formation", "down regulation of neurofibrillary tangle formation", "negative regulation of neurofibrillary tangle formation"], "types": ["T043"], "canonical_name": "negative regulation of neurofibrillary tangle assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neurofibrillary tangle assembly. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157]"}
{"concept_id": "C3824085", "aliases": ["down-regulation of flame-shaped neurofibrillary tangle assembly"], "types": ["T043"], "canonical_name": "down regulation of flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824086", "aliases": ["down-regulation of flame-shaped neurofibrillary tangle formation"], "types": ["T043"], "canonical_name": "down regulation of flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824087", "aliases": ["down-regulation of star-shaped neurofibrillary tangle assembly"], "types": ["T043"], "canonical_name": "down regulation of star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824088", "aliases": ["down-regulation of star-shaped neurofibrillary tangle formation"], "types": ["T043"], "canonical_name": "down regulation of star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824089", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824090", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824091", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824092", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824093", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824094", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824095", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neurofibrillary tangle assembly"}
{"concept_id": "C3824096", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neurofibrillary tangle formation"}
{"concept_id": "C3824097", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824098", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824099", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824100", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824101", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824102", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824103", "aliases": ["upregulation of neurofibrillary tangle assembly", "up regulation of neurofibrillary tangle formation", "up regulation of neurofibrillary tangle assembly", "up-regulation of neurofibrillary tangle assembly", "positive regulation of neurofibrillary tangle formation", "upregulation of neurofibrillary tangle formation", "up-regulation of neurofibrillary tangle formation"], "types": ["T043"], "canonical_name": "positive regulation of neurofibrillary tangle assembly", "definition": "Any process that activates or increases the frequency, rate or extent of neurofibrillary tangle assembly. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157]"}
{"concept_id": "C3824104", "aliases": [], "types": ["T043"], "canonical_name": "activation of flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824105", "aliases": [], "types": ["T043"], "canonical_name": "activation of flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824106", "aliases": [], "types": ["T043"], "canonical_name": "activation of neurofibrillary tangle assembly"}
{"concept_id": "C3824107", "aliases": [], "types": ["T043"], "canonical_name": "activation of neurofibrillary tangle formation"}
{"concept_id": "C3824108", "aliases": [], "types": ["T043"], "canonical_name": "activation of star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824109", "aliases": [], "types": ["T043"], "canonical_name": "activation of star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824110", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824111", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824112", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824113", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824114", "aliases": ["up-regulation of flame-shaped neurofibrillary tangle assembly"], "types": ["T043"], "canonical_name": "up regulation of flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824115", "aliases": ["up-regulation of flame-shaped neurofibrillary tangle formation"], "types": ["T043"], "canonical_name": "up regulation of flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824116", "aliases": ["up-regulation of star-shaped neurofibrillary tangle assembly"], "types": ["T043"], "canonical_name": "up regulation of star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824117", "aliases": ["up-regulation of star-shaped neurofibrillary tangle formation"], "types": ["T043"], "canonical_name": "up regulation of star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824118", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of flame-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824119", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824120", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of star-shaped neurofibrillary tangle assembly"}
{"concept_id": "C3824121", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of star-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824122", "aliases": ["down regulation of phospholipid efflux", "downregulation of phospholipid efflux", "down-regulation of phospholipid export", "negative regulation of phospholipid export", "downregulation of phospholipid export", "down regulation of phospholipid export", "down-regulation of phospholipid efflux"], "types": ["T044"], "canonical_name": "negative regulation of phospholipid efflux", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid efflux. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316]"}
{"concept_id": "C3824123", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phospholipid efflux"}
{"concept_id": "C3824124", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phospholipid export"}
{"concept_id": "C3824125", "aliases": ["regulation of lipid transport across blood brain barrier"], "types": ["T044"], "canonical_name": "regulation of lipid transport across blood-brain barrier", "definition": "Any process that modulates the frequency, rate or extent of lipid transport across blood-brain barrier. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162]"}
{"concept_id": "C3824126", "aliases": ["negative regulation of lipid transport across blood brain barrier", "downregulation of lipid transport across blood brain barrier", "down regulation of lipid transport across blood brain barrier", "down-regulation of lipid transport across blood brain barrier"], "types": ["T044"], "canonical_name": "negative regulation of lipid transport across blood-brain barrier", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lipid transport across blood-brain barrier. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162]"}
{"concept_id": "C3824127", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lipid transport across blood brain barrier"}
{"concept_id": "C3824128", "aliases": ["upregulation of lipid transport across blood brain barrier", "up-regulation of lipid transport across blood brain barrier", "up regulation of lipid transport across blood brain barrier", "positive regulation of lipid transport across blood brain barrier"], "types": ["T044"], "canonical_name": "positive regulation of lipid transport across blood-brain barrier", "definition": "Any process that activates or increases the frequency, rate or extent of lipid transport across blood-brain barrier. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162]"}
{"concept_id": "C3824129", "aliases": [], "types": ["T044"], "canonical_name": "activation of lipid transport across blood brain barrier"}
{"concept_id": "C3824130", "aliases": ["up-regulation of deubiquitination", "upregulation of protein deubiquitinylation", "upregulation of protein deubiquitylation", "positive regulation of protein deubiquitinylation", "up regulation of deubiquitination", "up regulation of protein deubiquitination", "positive regulation of deubiquitination", "up-regulation of protein deubiquitination", "up regulation of protein deubiquitinylation", "positive regulation of protein deubiquitylation", "up-regulation of protein deubiquitylation", "upregulation of deubiquitination", "upregulation of protein deubiquitination", "up regulation of protein deubiquitylation", "up-regulation of protein deubiquitinylation"], "types": ["T044"], "canonical_name": "positive regulation of protein deubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of protein deubiquitination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]"}
{"concept_id": "C3824131", "aliases": [], "types": ["T044"], "canonical_name": "activation of deubiquitination"}
{"concept_id": "C3824132", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein deubiquitination"}
{"concept_id": "C3824133", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein deubiquitinylation"}
{"concept_id": "C3824134", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein deubiquitylation"}
{"concept_id": "C3824135", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein K63-linked deubiquitination", "definition": "Any process that modulates the frequency, rate or extent of protein K63-linked deubiquitination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]"}
{"concept_id": "C3824136", "aliases": ["down-regulation of protein K63-linked deubiquitination", "down regulation of protein K63-linked deubiquitination", "downregulation of protein K63-linked deubiquitination"], "types": ["T044"], "canonical_name": "negative regulation of protein K63-linked deubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked deubiquitination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]"}
{"concept_id": "C3824137", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein K63-linked deubiquitination"}
{"concept_id": "C3824138", "aliases": ["up-regulation of protein K63-linked deubiquitination", "upregulation of protein K63-linked deubiquitination", "up regulation of protein K63-linked deubiquitination"], "types": ["T044"], "canonical_name": "positive regulation of protein K63-linked deubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]"}
{"concept_id": "C3824139", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein K63-linked deubiquitination"}
{"concept_id": "C3824140", "aliases": ["upregulation of Lys63-specific deubiquitinase activity", "up regulation of Lys63-specific deubiquitinase activity", "up-regulation of Lys63-specific deubiquitinase activity"], "types": ["T044"], "canonical_name": "positive regulation of Lys63-specific deubiquitinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]"}
{"concept_id": "C3824141", "aliases": [], "types": ["T044"], "canonical_name": "activation of Lys63-specific deubiquitinase activity"}
{"concept_id": "C3824142", "aliases": ["organelle degradation"], "types": ["T043"], "canonical_name": "organelle disassembly", "definition": "The disaggregation of an organelle into its constituent components. [GO_REF:0000079, GOC:TermGenie]"}
{"concept_id": "C3824143", "aliases": ["proteasome disassembly", "proteasome degradation"], "types": ["T044"], "canonical_name": "proteasome complex disassembly", "definition": "The disaggregation of a proteasome complex into its constituent components. [GO_REF:0000079, GOC:TermGenie]"}
{"concept_id": "C3824144", "aliases": [], "types": ["T044"], "canonical_name": "26S proteasome disassembly"}
{"concept_id": "C3824145", "aliases": [], "types": ["T038"], "canonical_name": "regulation of bone development", "definition": "Any process that modulates the frequency, rate or extent of bone development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]"}
{"concept_id": "C3824146", "aliases": ["downregulation of bone development", "down regulation of bone development", "down-regulation of bone development"], "types": ["T039"], "canonical_name": "negative regulation of bone development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of bone development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]"}
{"concept_id": "C3824147", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of bone development"}
{"concept_id": "C3824148", "aliases": ["up regulation of bone development", "upregulation of bone development", "up-regulation of bone development"], "types": ["T039"], "canonical_name": "positive regulation of bone development", "definition": "Any process that activates or increases the frequency, rate or extent of bone development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]"}
{"concept_id": "C3824149", "aliases": [], "types": ["T039"], "canonical_name": "activation of bone development"}
{"concept_id": "C3824150", "aliases": ["DIF-1", "cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one", "response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one", "response to differentiation-inducing factor 1"], "types": ["T043"], "canonical_name": "cellular response to differentiation-inducing factor 1", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22365144]"}
{"concept_id": "C3824151", "aliases": ["regulation of acetylneuraminidase activity", "regulation of neuraminidase activity", "regulation of sialidase activity", "regulation of acetylneuraminyl hydrolase activity", "regulation of N-acylneuraminate glycohydrolase activity", "regulation of alpha-neuraminidase activity"], "types": ["T044"], "canonical_name": "regulation of exo-alpha-sialidase activity", "definition": "Any process that modulates the frequency, rate or extent of exo-alpha-sialidase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]"}
{"concept_id": "C3824152", "aliases": ["down regulation of sialidase activity", "down-regulation of sialidase activity", "downregulation of acetylneuraminidase activity", "downregulation of neuraminidase activity", "down-regulation of acetylneuraminyl hydrolase activity", "down-regulation of neuraminidase activity", "negative regulation of sialidase activity", "downregulation of sialidase activity", "down-regulation of N-acylneuraminate glycohydrolase activity", "downregulation of acetylneuraminyl hydrolase activity", "downregulation of alpha-neuraminidase activity", "down regulation of N-acylneuraminate glycohydrolase activity", "negative regulation of acetylneuraminyl hydrolase activity", "negative regulation of neuraminidase activity", "down regulation of neuraminidase activity", "down regulation of alpha-neuraminidase activity", "downregulation of exo-alpha-sialidase activity", "negative regulation of N-acylneuraminate glycohydrolase activity", "downregulation of N-acylneuraminate glycohydrolase activity", "negative regulation of acetylneuraminidase activity", "down-regulation of alpha-neuraminidase activity", "down-regulation of acetylneuraminidase activity", "down regulation of exo-alpha-sialidase activity", "down-regulation of exo-alpha-sialidase activity", "down regulation of acetylneuraminyl hydrolase activity", "negative regulation of alpha-neuraminidase activity", "down regulation of acetylneuraminidase activity"], "types": ["T044"], "canonical_name": "negative regulation of exo-alpha-sialidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of exo-alpha-sialidase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]"}
{"concept_id": "C3824153", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acetylneuraminidase activity"}
{"concept_id": "C3824154", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acetylneuraminyl hydrolase activity"}
{"concept_id": "C3824155", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of alpha-neuraminidase activity"}
{"concept_id": "C3824156", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of exo-alpha-sialidase activity"}
{"concept_id": "C3824157", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of N-acylneuraminate glycohydrolase activity"}
{"concept_id": "C3824158", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of neuraminidase activity"}
{"concept_id": "C3824159", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sialidase activity"}
{"concept_id": "C3824160", "aliases": ["upregulation of N-acylneuraminate glycohydrolase activity", "up regulation of sialidase activity", "up regulation of acetylneuraminyl hydrolase activity", "up regulation of N-acylneuraminate glycohydrolase activity", "positive regulation of neuraminidase activity", "up-regulation of acetylneuraminyl hydrolase activity", "upregulation of acetylneuraminyl hydrolase activity", "up-regulation of neuraminidase activity", "up-regulation of N-acylneuraminate glycohydrolase activity", "positive regulation of N-acylneuraminate glycohydrolase activity", "up-regulation of sialidase activity", "upregulation of acetylneuraminidase activity", "up-regulation of acetylneuraminidase activity", "positive regulation of acetylneuraminyl hydrolase activity", "up regulation of neuraminidase activity", "up-regulation of alpha-neuraminidase activity", "up regulation of alpha-neuraminidase activity", "positive regulation of alpha-neuraminidase activity", "upregulation of neuraminidase activity", "upregulation of alpha-neuraminidase activity", "positive regulation of sialidase activity", "upregulation of exo-alpha-sialidase activity", "up regulation of acetylneuraminidase activity", "up regulation of exo-alpha-sialidase activity", "upregulation of sialidase activity", "up-regulation of exo-alpha-sialidase activity", "positive regulation of acetylneuraminidase activity"], "types": ["T044"], "canonical_name": "positive regulation of exo-alpha-sialidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of exo-alpha-sialidase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]"}
{"concept_id": "C3824161", "aliases": [], "types": ["T044"], "canonical_name": "activation of acetylneuraminidase activity"}
{"concept_id": "C3824162", "aliases": [], "types": ["T044"], "canonical_name": "activation of acetylneuraminyl hydrolase activity"}
{"concept_id": "C3824163", "aliases": [], "types": ["T044"], "canonical_name": "activation of alpha-neuraminidase activity"}
{"concept_id": "C3824164", "aliases": [], "types": ["T044"], "canonical_name": "activation of exo-alpha-sialidase activity"}
{"concept_id": "C3824165", "aliases": [], "types": ["T044"], "canonical_name": "activation of N-acylneuraminate glycohydrolase activity"}
{"concept_id": "C3824166", "aliases": [], "types": ["T044"], "canonical_name": "activation of neuraminidase activity"}
{"concept_id": "C3824167", "aliases": [], "types": ["T044"], "canonical_name": "activation of sialidase activity"}
{"concept_id": "C3824168", "aliases": ["regulation of glycoprotein metabolism"], "types": ["T040"], "canonical_name": "regulation of glycoprotein metabolic process", "definition": "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]"}
{"concept_id": "C3824169", "aliases": ["down regulation of glycoprotein metabolic process", "downregulation of glycoprotein metabolism", "downregulation of glycoprotein metabolic process", "down regulation of glycoprotein metabolism", "negative regulation of glycoprotein metabolism", "down-regulation of glycoprotein metabolism", "down-regulation of glycoprotein metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of glycoprotein metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]"}
{"concept_id": "C3824170", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glycoprotein metabolic process"}
{"concept_id": "C3824171", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glycoprotein metabolism"}
{"concept_id": "C3824172", "aliases": ["upregulation of glycoprotein metabolism", "up regulation of glycoprotein metabolic process", "up regulation of glycoprotein metabolism", "up-regulation of glycoprotein metabolism", "upregulation of glycoprotein metabolic process", "positive regulation of glycoprotein metabolism", "up-regulation of glycoprotein metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of glycoprotein metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]"}
{"concept_id": "C3824173", "aliases": [], "types": ["T044"], "canonical_name": "activation of glycoprotein metabolic process"}
{"concept_id": "C3824174", "aliases": [], "types": ["T044"], "canonical_name": "activation of glycoprotein metabolism"}
{"concept_id": "C3824175", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands", "definition": "Any process that modulates the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands. [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046]"}
{"concept_id": "C3824176", "aliases": ["upregulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands", "up regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands", "up-regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands"], "types": ["T044"], "canonical_name": "positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands", "definition": "Any process that activates or increases the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands. [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046]"}
{"concept_id": "C3824177", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands"}
{"concept_id": "C3824178", "aliases": ["regulation of ascospore-type prospore membrane assembly", "regulation of FSM biosynthesis", "regulation of FSM formation", "regulation of forespore membrane biosynthesis", "regulation of FSM assembly", "regulation of forespore membrane formation"], "types": ["T043"], "canonical_name": "regulation of ascospore-type prospore membrane formation", "definition": "Any process that modulates the frequency, rate or extent of formation of an ascospore-type prospore membrane. [GO_REF:0000058, GOC:TermGenie, PMID:11405625]"}
{"concept_id": "C3824179", "aliases": ["up regulation of forespore membrane biosynthesis", "upregulation of FSM formation", "up regulation of FSM formation", "up regulation of ascospore-type prospore membrane assembly", "up regulation of FSM assembly", "up-regulation of FSM formation", "positive regulation of forespore membrane biosynthesis", "positive regulation of FSM assembly", "positive regulation of FSM formation", "upregulation of ascospore-type prospore membrane assembly", "up-regulation of FSM assembly", "positive regulation of ascospore-type prospore membrane assembly", "up-regulation of ascospore-type prospore membrane assembly", "up regulation of forespore membrane formation", "upregulation of FSM biosynthesis", "up-regulation of FSM biosynthesis", "upregulation of forespore membrane biosynthesis", "upregulation of forespore membrane formation", "up-regulation of forespore membrane formation", "up regulation of FSM biosynthesis", "positive regulation of FSM biosynthesis", "upregulation of FSM assembly", "up-regulation of forespore membrane biosynthesis", "positive regulation of forespore membrane formation"], "types": ["T039"], "canonical_name": "positive regulation of ascospore-type prospore membrane formation", "definition": "Any process that activates or increases the frequency, rate or extent of formation of an ascospore-type prospore membrane. [GO_REF:0000058, GOC:TermGenie, PMID:11405625]"}
{"concept_id": "C3824180", "aliases": [], "types": ["T039"], "canonical_name": "activation of ascospore-type prospore membrane assembly"}
{"concept_id": "C3824181", "aliases": [], "types": ["T039"], "canonical_name": "activation of forespore membrane biosynthesis"}
{"concept_id": "C3824182", "aliases": [], "types": ["T039"], "canonical_name": "activation of forespore membrane formation"}
{"concept_id": "C3824183", "aliases": [], "types": ["T039"], "canonical_name": "activation of FSM assembly"}
{"concept_id": "C3824184", "aliases": [], "types": ["T039"], "canonical_name": "activation of FSM biosynthesis"}
{"concept_id": "C3824185", "aliases": [], "types": ["T039"], "canonical_name": "activation of FSM formation"}
{"concept_id": "C3824186", "aliases": [], "types": ["T045"], "canonical_name": "regulation of RNA polymerase II regulatory region sequence-specific DNA binding", "definition": "Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding. [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326]"}
{"concept_id": "C3824187", "aliases": ["downregulation of RNA polymerase II regulatory region sequence-specific DNA binding", "down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding", "down regulation of RNA polymerase II regulatory region sequence-specific DNA binding"], "types": ["T044"], "canonical_name": "negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding. [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326]"}
{"concept_id": "C3824188", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA polymerase II regulatory region sequence-specific DNA binding"}
{"concept_id": "C3824189", "aliases": [], "types": ["T038"], "canonical_name": "regulation of opsonization", "definition": "Any process that modulates the frequency, rate or extent of opsonization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221]"}
{"concept_id": "C3824190", "aliases": ["up-regulation of opsonization", "up regulation of opsonization", "upregulation of opsonization"], "types": ["T039"], "canonical_name": "positive regulation of opsonization", "definition": "Any process that activates or increases the frequency, rate or extent of opsonization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221]"}
{"concept_id": "C3824191", "aliases": [], "types": ["T039"], "canonical_name": "activation of opsonization"}
{"concept_id": "C3824192", "aliases": [], "types": ["T044"], "canonical_name": "regulation of microtubule plus-end binding", "definition": "Any process that modulates the frequency, rate or extent of microtubule plus-end binding. [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]"}
{"concept_id": "C3824193", "aliases": ["downregulation of microtubule plus-end binding", "down regulation of microtubule plus-end binding", "down-regulation of microtubule plus-end binding"], "types": ["T044"], "canonical_name": "negative regulation of microtubule plus-end binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding. [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]"}
{"concept_id": "C3824194", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of microtubule plus-end binding"}
{"concept_id": "C3824195", "aliases": ["up-regulation of microtubule plus-end binding", "upregulation of microtubule plus-end binding", "up regulation of microtubule plus-end binding"], "types": ["T044"], "canonical_name": "positive regulation of microtubule plus-end binding", "definition": "Any process that activates or increases the frequency, rate or extent of microtubule plus-end binding. [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]"}
{"concept_id": "C3824196", "aliases": [], "types": ["T044"], "canonical_name": "activation of microtubule plus-end binding"}
{"concept_id": "C3824197", "aliases": [], "types": ["T045"], "canonical_name": "polyuridylation-dependent mRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA. [GOC:vw, PMID:23503588]"}
{"concept_id": "C3824198", "aliases": [], "types": ["T043"], "canonical_name": "cell wall polysaccharide catabolic process involved in abscission", "definition": "Any cell wall polysaccharide catabolic process that is involved in abscission. [GOC:TermGenie, PMID:23479623]"}
{"concept_id": "C3824199", "aliases": ["replication inhibiting complex location"], "types": ["T026"], "canonical_name": "replication inhibiting complex", "definition": "A protein complex that inhibits multiple events of replication initiation during one replication cycle. [GOC:bhm, PMID:21708944]"}
{"concept_id": "C3824200", "aliases": [], "types": ["T040"], "canonical_name": "cartilage homeostasis", "definition": "A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function. [GOC:hjd, PMID:21652695]"}
{"concept_id": "C3824201", "aliases": ["beta-phenylethylamine receptor activity"], "types": ["T044"], "canonical_name": "2-phenylethylamine receptor activity", "definition": "Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity. [PMID:16878137]"}
{"concept_id": "C3824202", "aliases": [], "types": ["T044"], "canonical_name": "trimethylamine receptor activity", "definition": "Combining with the biogenic amine trimethylamine to initiate a change in cell activity. [PMID:16878137]"}
{"concept_id": "C3824203", "aliases": ["DnaA-L2 complex location"], "types": ["T026"], "canonical_name": "DnaA-L2 complex", "definition": "A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2. [GOC:bhm, PMID:21288885]"}
{"concept_id": "C3824204", "aliases": ["DnaA-Hda complex location"], "types": ["T026"], "canonical_name": "DnaA-Hda complex", "definition": "A protein complex that inactivates the function of DnaA by inhibiting the phosphorylation of DnaA-ADP to DnaA-ATP and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of DnaA and Hda. [GOC:bhm, PMID:21708944]"}
{"concept_id": "C3824205", "aliases": ["DnaA-Dps complex location"], "types": ["T026"], "canonical_name": "DnaA-Dps complex", "definition": "A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps. [GOC:bhm, PMID:18284581]"}
{"concept_id": "C3824206", "aliases": ["Hda-dpo3b complex location", "Hda-dpo3b complex", "Hda-DnaN complex", "Hda-DnaN complex location", "Hda-beta clamp complex location"], "types": ["T026"], "canonical_name": "Hda-beta clamp complex", "definition": "A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda. [GOC:bhm, PMID:15150238]"}
{"concept_id": "C3824207", "aliases": [], "types": ["T043"], "canonical_name": "lens fiber cell apoptotic process", "definition": "Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. [CL:0011004, GOC:hjd, PMID:11095619]"}
{"concept_id": "C3824208", "aliases": ["methanol-specific methylcobalamin:coenzyme M methyltransferase activity", "methanol-specific methylcobalamin:CoM methyltransferase activity", "methanol-specific methylcobalamin: coenzyme M methyltransferase activity"], "types": ["T044"], "canonical_name": "[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase", "definition": "Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-coenzyme M + a [Co(I) methanol-specific corrinoid protein] + H+. [GOC:hjd, PMID:10077852, RHEA:45208]"}
{"concept_id": "C3824209", "aliases": ["response to nerve growth factor stimulus"], "types": ["T043"], "canonical_name": "response to nerve growth factor", "definition": "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. [PMID:22399805]"}
{"concept_id": "C3824210", "aliases": ["cellular response to NGF"], "types": ["T043"], "canonical_name": "cellular response to nerve growth factor stimulus", "definition": "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. [PMID:22399805, Wikipedia:Nerve_growth_factor]"}
{"concept_id": "C3824211", "aliases": [], "types": ["T044"], "canonical_name": "sodium-dependent self proteolysis", "definition": "The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. [PMID:20460380]"}
{"concept_id": "C3824212", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent self proteolysis", "definition": "The calcium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. [PMID:20460380]"}
{"concept_id": "C3824215", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:kmv, PMID:16166371]"}
{"concept_id": "C3824216", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to superoxide", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. [GOC:kmv, PMID:12869585, PMID:16166371]"}
{"concept_id": "C3824217", "aliases": ["SeqA-DNA complex location"], "types": ["T026"], "canonical_name": "SeqA-DNA complex", "definition": "A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle. [GOC:bhm, PMID:12379844, PMID:15933720, PMID:23149570]"}
{"concept_id": "C3824218", "aliases": ["SeqA-dsDNA complex location"], "types": ["T026"], "canonical_name": "SeqA-dsDNA complex"}
{"concept_id": "C3824219", "aliases": ["SeqA-hemimethylated DNA complex location"], "types": ["T026"], "canonical_name": "SeqA-hemimethylated DNA complex"}
{"concept_id": "C3824220", "aliases": ["SeqA-hemimethylation dsDNA complex location"], "types": ["T026"], "canonical_name": "SeqA-hemimethylation dsDNA complex"}
{"concept_id": "C3824221", "aliases": ["core primosome", "core primosome complex location"], "types": ["T026"], "canonical_name": "core primosome complex", "definition": "A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication. [GOC:bhm, PMID:21856207]"}
{"concept_id": "C3824222", "aliases": ["pre-primosome complex location", "preprimosome complex", "preprimosome complex location", "pre-priming complex location", "prereplication complex location", "pre-priming complex", "prereplication complex", "preprimosome", "pre-primosome"], "types": ["T026"], "canonical_name": "pre-primosome complex", "definition": "Any of the protein-DNA complexes that contain a DNA helicase and associated protein(s) at the origin of replication, and build up to assembling the core primosome. The associated protein(s) chaperone the helicase to the DNA, and assembly of the pre-primosome is essential for the initiation or restart of replication. Pre-primosome complexes lack a primase component. [GOC:bhm, PMID:18179598, PMID:20129058, PMID:8663105]"}
{"concept_id": "C3824223", "aliases": ["DnaB-DnaC complex location"], "types": ["T026"], "canonical_name": "DnaB-DnaC complex", "definition": "A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC). [GOC:bhm, PMID:20129058]"}
{"concept_id": "C3824224", "aliases": ["DnaB6-DnaC3 complex location"], "types": ["T026"], "canonical_name": "DnaB6-DnaC3 complex"}
{"concept_id": "C3824225", "aliases": ["DnaB6-DnaC6 complex location"], "types": ["T026"], "canonical_name": "DnaB6-DnaC6 complex"}
{"concept_id": "C3824226", "aliases": ["helicase-loading complex location"], "types": ["T026"], "canonical_name": "helicase-loading complex"}
{"concept_id": "C3824227", "aliases": ["DnaA-oriC complex location"], "types": ["T026"], "canonical_name": "DnaA-oriC complex", "definition": "A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle. [GOC:bhm, PMID:19833870]"}
{"concept_id": "C3824228", "aliases": ["DnaA-DNA complex location"], "types": ["T026"], "canonical_name": "DnaA-DNA complex"}
{"concept_id": "C3824229", "aliases": ["DnaA-DiaA-DNA complex", "DnaA-DiaA-DNA complex location", "DnaA-DiaA complex location"], "types": ["T026"], "canonical_name": "DnaA-DiaA complex", "definition": "A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA. [GOC:bhm, PMID:15326179, PMID:17699754]"}
{"concept_id": "C3824230", "aliases": ["DnaA-HU complex location", "DnaA-HU-DNA complex location", "DnaA-HU-DNA complex"], "types": ["T026"], "canonical_name": "DnaA-HU complex", "definition": "A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC. [GOC:bhm, PMID:18179598]"}
{"concept_id": "C3824231", "aliases": ["DNA bending complex location"], "types": ["T026"], "canonical_name": "DNA bending complex", "definition": "A protein-DNA complex that contains DNA in combination with a protein which binds to and bends DNA. Often plays a role in DNA compaction. [GOC:bhm, PMID:17097674]"}
{"concept_id": "C3824232", "aliases": ["histone-like DNA binding complex location"], "types": ["T026"], "canonical_name": "histone-like DNA binding complex"}
{"concept_id": "C3824234", "aliases": ["1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity"], "types": ["T044"], "canonical_name": "thiazole synthase activity", "definition": "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O. [EC:2.8.1.10, GOC:cjk, PMID:22031445, RHEA:26297]"}
{"concept_id": "C3824235", "aliases": [], "types": ["T044"], "canonical_name": "protein linear deubiquitination", "definition": "A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein. [PMID:23708998]"}
{"concept_id": "C3824236", "aliases": ["unilateral interspecific incompatibility"], "types": ["T054"], "canonical_name": "rejection of pollen from other species", "definition": "The recognition and rejection of pollen of one species by cells in the stigma of another species. [PMID:21205670]"}
{"concept_id": "C3824237", "aliases": ["spermatoproteasome complex location"], "types": ["T026"], "canonical_name": "spermatoproteasome complex", "definition": "A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity. [GOC:sp, PMID:23706739]"}
{"concept_id": "C3824238", "aliases": ["ribosome quality control complex", "ribosome quality control complex location", "RQC complex location", "ribosome-bound quality control complex location", "ribosome-bound quality control complex"], "types": ["T026"], "canonical_name": "RQC complex", "definition": "A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins. [GOC:rb, PMID:23178123, PMID:23232563]"}
{"concept_id": "C3824239", "aliases": ["RNA Polymerase I complex assembly", "DNA-directed RNA polymerase I complex assembly"], "types": ["T044"], "canonical_name": "RNA polymerase I assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex. [GOC:rb, PMID:23459708]"}
{"concept_id": "C3824240", "aliases": ["DNA-directed RNA polymerase II, core complex assembly"], "types": ["T044"], "canonical_name": "RNA polymerase II core complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex. [GOC:rb, PMID:23459708]"}
{"concept_id": "C3824241", "aliases": [], "types": ["T044"], "canonical_name": "RNA Polymerase II assembly"}
{"concept_id": "C3824242", "aliases": ["RNA Polymerase III complex assembly", "DNA-directed RNA polymerase III complex assembly"], "types": ["T044"], "canonical_name": "RNA polymerase III assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex. [GOC:rb, PMID:23459708]"}
{"concept_id": "C3824243", "aliases": [], "types": ["T060"], "canonical_name": "ribosome-associated degradation"}
{"concept_id": "C3824244", "aliases": ["B cell receptor extrinsic apoptotic signaling pathway"], "types": ["T044"], "canonical_name": "B cell receptor apoptotic signaling pathway", "definition": "An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:15214043]"}
{"concept_id": "C3824245", "aliases": [], "types": ["T044"], "canonical_name": "extrinsic apoptotic signaling pathway via B cell antigen receptor"}
{"concept_id": "C3824246", "aliases": [], "types": ["T044"], "canonical_name": "extrinsic apoptotic signaling pathway via BCR"}
{"concept_id": "C3824248", "aliases": ["ATP-dependent RNA helicase inhibitor activity"], "types": ["T044"], "canonical_name": "RNA helicase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of an RNA helicase. [GOC:rb, PMID:23721653]"}
{"concept_id": "C3824249", "aliases": ["mRNA-protein complex assembly", "mRNP assembly", "mRNP complex assembly"], "types": ["T045"], "canonical_name": "messenger ribonucleoprotein complex assembly", "definition": "The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex. [GOC:rb, PMID:23721653]"}
{"concept_id": "C3824250", "aliases": [], "types": ["T045"], "canonical_name": "messenger ribonucleoprotein assembly"}
{"concept_id": "C3824251", "aliases": ["histone-like protein H-NS complex", "histone-like protein H-NS complex location", "DNA-binding protein H-NS complex location", "DNA-binding protein H-NS complex", "H-NS complex location"], "types": ["T026"], "canonical_name": "H-NS complex", "definition": "A multimer of H-NS proteins that is involved in bacterial nucleoid condensation and negative regulation of global gene expression by directly binding to promoter regions. Recognizes both structural and sequence-specific motifs in double-stranded DNA and has binding preference for bent DNA. [GOC:bhm, PMID:12592399]"}
{"concept_id": "C3824253", "aliases": ["L-leucine import into cell", "L-leucine import across plasma membrane"], "types": ["T043"], "definition": "The directed movement of L-leucine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]", "canonical_name": "leucine uptake"}
{"concept_id": "C3824255", "aliases": [], "types": ["T026"], "canonical_name": "messenger ribonucleoprotein particle"}
{"concept_id": "C3824256", "aliases": ["DiaA homotetramer", "DiaA complex location"], "types": ["T026"], "canonical_name": "DiaA complex", "definition": "A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation. [GOC:bhm, PMID:17699754]"}
{"concept_id": "C3824258", "aliases": [], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered. [GOC:krc, GOC:mtg_apoptosis, PMID:16571598]"}
{"concept_id": "C3824261", "aliases": ["SEACIT complex", "SEACIT complex location", "IML1 complex location", "IML1 complex", "GATOR1 complex location"], "types": ["T026"], "canonical_name": "GATOR1 complex", "definition": "A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]"}
{"concept_id": "C3824262", "aliases": ["Gtr1-Gtr2 GTPase complex location"], "types": ["T026"], "canonical_name": "Gtr1-Gtr2 GTPase complex", "definition": "A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins. [GOC:rb, PMID:10388807, PMID:16143306]"}
{"concept_id": "C3824264", "aliases": ["molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex location"], "types": ["T026"], "canonical_name": "molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex", "definition": "A heterodimeric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin (MPT) cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; Moco biosynthesis and its constituent molecules are evolutionarily conserved. [GOC:bhm, pmid:11713534, pmid:16669776]"}
{"concept_id": "C3824265", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cell apoptotic process involved in palatal shelf morphogenesis", "definition": "An apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf. [GOC:dph, GOC:mtg_apoptosis, PMID:16607638]"}
{"concept_id": "C3824266", "aliases": [], "types": ["T044"], "canonical_name": "flavonoid sulfotransferase activity", "definition": "Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative. [PMID:23611783]"}
{"concept_id": "C3824267", "aliases": ["linoleate:oxygen 9S-oxidoreductase activity"], "types": ["T044"], "canonical_name": "linoleate 9S-lipoxygenase activity", "definition": "Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate. [GOC:rph, RHEA:30291]"}
{"concept_id": "C3824268", "aliases": [], "types": ["T044"], "canonical_name": "9-lipoxygenase activity"}
{"concept_id": "C3824269", "aliases": [], "types": ["T044"], "canonical_name": "9S-lipoxygenase activity"}
{"concept_id": "C3824270", "aliases": [], "types": ["T044"], "canonical_name": "linoleate 9-lipoxygenase activity"}
{"concept_id": "C3824271", "aliases": [], "types": ["T044"], "canonical_name": "plant seed peroxidase activity", "definition": "Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH. [PMID:19467604]"}
{"concept_id": "C3824272", "aliases": [], "types": ["T044"], "canonical_name": "peroxygenase activity"}
{"concept_id": "C3824273", "aliases": ["neuronal cell projection extension", "neuron protrusion extension", "neuron process extension"], "types": ["T043"], "canonical_name": "neuron projection extension", "definition": "Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:BHF, GOC:rl, PMID:22790009]"}
{"concept_id": "C3824274", "aliases": [], "types": ["T043"], "canonical_name": "neurite extension"}
{"concept_id": "C3824275", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to nuclear periphery", "definition": "A process in which a protein is transported to, or maintained in, a location within the nuclear periphery. [GOC:mah, PMID:23703609]"}
{"concept_id": "C3824276", "aliases": ["MPT synthase complex location"], "types": ["T026"], "canonical_name": "MPT synthase complex", "definition": "A heterodimeric protein complex which catalyses sulfur transfer from the sulfur carrier subunit of MPT synthase to precursor Z to synthesize MPT as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved. [GOC:bhm, PMID:11135669, PMID:16669776, Reactome:R-HSA-947581]"}
{"concept_id": "C3824277", "aliases": ["molybdopterin cofactor (Moco) biosynthesis sulfurtransferase complex location"], "types": ["T026"], "canonical_name": "molybdopterin cofactor (Moco) biosynthesis sulfurtransferase complex"}
{"concept_id": "C3824278", "aliases": [], "types": ["T045"], "canonical_name": "chromatin silencing at centromere outer repeat region"}
{"concept_id": "C3824279", "aliases": [], "types": ["T045"], "canonical_name": "chromatin silencing at pericentric region"}
{"concept_id": "C3824280", "aliases": ["envenomation resulting in hemolysis in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in hemolysis in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with hemolysis in the bitten organism. [PMID:21590705]"}
{"concept_id": "C3824281", "aliases": [], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway in response to hypoxia", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:20436456]"}
{"concept_id": "C3824282", "aliases": [], "types": ["T044"], "canonical_name": "maintenance of translational fidelity", "definition": "Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template. [GOC:hjd, ISBN:9781936113460, PMID:21841312]"}
{"concept_id": "C3824283", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to rhabdomere", "definition": "A process in which a protein is transported to, or maintained in, a location within a rhabdomere. [GOC:sart, PMID:8335687]"}
{"concept_id": "C3824284", "aliases": [], "types": ["T044"], "canonical_name": "talin binding", "definition": "Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. [GOC:hjd, PMID:23372168]"}
{"concept_id": "C3824285", "aliases": ["glutamate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "glutamate dehydrogenase complex", "definition": "A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies. [GOC:bhm, PMID:22393408, PMID:23412807]"}
{"concept_id": "C3824286", "aliases": ["dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) complex location"], "types": ["T026"], "canonical_name": "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) complex"}
{"concept_id": "C3824287", "aliases": ["glutamate dehydrogenase (NADP+) complex location"], "types": ["T026"], "canonical_name": "glutamate dehydrogenase (NADP+) complex"}
{"concept_id": "C3824288", "aliases": ["glutamic acid dehydrogenase complex location"], "types": ["T026"], "canonical_name": "glutamic acid dehydrogenase complex"}
{"concept_id": "C3824289", "aliases": ["glutamic dehydrogenase complex location"], "types": ["T026"], "canonical_name": "glutamic dehydrogenase complex"}
{"concept_id": "C3824290", "aliases": ["L-glutamate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "L-glutamate dehydrogenase complex"}
{"concept_id": "C3824291", "aliases": ["L-glutamate:NADP+ oxidoreductase (deaminating) complex location"], "types": ["T026"], "canonical_name": "L-glutamate:NADP+ oxidoreductase (deaminating) complex"}
{"concept_id": "C3824292", "aliases": ["L-glutamic acid dehydrogenase complex location"], "types": ["T026"], "canonical_name": "L-glutamic acid dehydrogenase complex"}
{"concept_id": "C3824293", "aliases": ["NAD(P)-glutamate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "NAD(P)-glutamate dehydrogenase complex"}
{"concept_id": "C3824294", "aliases": ["NAD(P)H-dependent glutamate dehydrogenase complex location"], "types": ["T026"], "canonical_name": "NAD(P)H-dependent glutamate dehydrogenase complex"}
{"concept_id": "C3824295", "aliases": ["vascular endothelial growth factor A complex", "vascular endothelial growth factor A complex location", "VEGF-A complex location"], "types": ["T026"], "canonical_name": "VEGF-A complex", "definition": "A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase. [GOC:bf, GOC:bhm, PMID:12207021, PMID:19658168]"}
{"concept_id": "C3824296", "aliases": ["protein localisation to cell tip"], "types": ["T043"], "canonical_name": "protein localization to cell tip", "definition": "A process in which a protein is transported to, or maintained in, a location at the cell tip. [PMID:22768263]"}
{"concept_id": "C3824297", "aliases": ["protein localization to telomeric heterochromatin"], "types": ["T045"], "canonical_name": "protein localisation to telomeric heterochromatin"}
{"concept_id": "C3824298", "aliases": ["maintenance of protein localisation to heterochromatin"], "types": ["T038"], "canonical_name": "maintenance of protein localization to heterochromatin", "definition": "A process in which a protein is maintained in a location in telomeric heterochromatin. [PMID:21300781]"}
{"concept_id": "C3824299", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of protein location in heterochromatin"}
{"concept_id": "C3824300", "aliases": ["EIIA(Glc)-MalFGK2 complex", "enzyme IIA-maltose transporter complex location", "EIIA(Glc)-maltose transporter complex", "EIIA(Glc)-maltose transporter complex location", "EIIA(Glc)-MalFGK2 complex location"], "types": ["T026"], "canonical_name": "enzyme IIA-maltose transporter complex", "definition": "A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter. [GOC:bf, GOC:bhm, PMID:23770568]"}
{"concept_id": "C3824301", "aliases": ["maltose transporter inhibitor complex location"], "types": ["T026"], "canonical_name": "maltose transporter inhibitor complex"}
{"concept_id": "C3824302", "aliases": ["Dsc complex assembly"], "types": ["T044"], "canonical_name": "Dsc E3 ubiquitin ligase complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane. [GOC:mah, PMID:23760507]"}
{"concept_id": "C3824303", "aliases": ["DnaB-DnaG complex location"], "types": ["T026"], "canonical_name": "DnaB-DnaG complex", "definition": "A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes. [GOC:bhm, PMID:14557266]"}
{"concept_id": "C3824304", "aliases": ["DnaB-DnaG primosome complex location"], "types": ["T026"], "canonical_name": "DnaB-DnaG primosome complex"}
{"concept_id": "C3824305", "aliases": ["DnaA-DnaB-DnaC complex location"], "types": ["T026"], "canonical_name": "DnaA-DnaB-DnaC complex", "definition": "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC bound to the DNA-bound DNA replication initiation protein DnaA. Essential for DNA replication initiation. [GOC:bhm, PMID:20129058]"}
{"concept_id": "C3824306", "aliases": ["DnaB-DnaC-DnaT-PriA-PriB preprimosome", "DnaB-DnaC-DnaT-PriA-PriB complex location"], "types": ["T026"], "canonical_name": "DnaB-DnaC-DnaT-PriA-PriB complex", "definition": "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired. [GOC:bhm, PMID:8663105]"}
{"concept_id": "C3824307", "aliases": ["phi-X174-type preprimosome"], "types": ["T026"], "canonical_name": "phi-X174-type preprimosome"}
{"concept_id": "C3824308", "aliases": ["DnaB-DnaC-DnaT-PriA-PriC complex location", "DnaB-DnaC-DnaT-PriA-PriC preprimosome"], "types": ["T026"], "canonical_name": "DnaB-DnaC-DnaT-PriA-PriC complex", "definition": "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired. [GOC:bhm, PMID:8663105]"}
{"concept_id": "C3824309", "aliases": ["DnaB-DnaC-Rep-PriC preprimosome", "DnaB-DnaC-Rep-PriC complex location"], "types": ["T026"], "canonical_name": "DnaB-DnaC-Rep-PriC complex", "definition": "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired. [GOC:bhm, PMID:19941825, PMID:8663105]"}
{"concept_id": "C3824310", "aliases": ["DnaB hexamer", "DnaB helicase complex location"], "types": ["T026"], "canonical_name": "DnaB helicase complex", "definition": "A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair. [GOC:bhm, PMID:17947583]"}
{"concept_id": "C3824311", "aliases": [], "types": ["T044"], "canonical_name": "histone deacetylase activity (H3-K4 specific)", "definition": "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein. [GOC:al, PMID:23771057, PMID:28450737]"}
{"concept_id": "C3824313", "aliases": [], "types": ["T045"], "canonical_name": "ATP-dependent Holliday junction helicase activity"}
{"concept_id": "C3824314", "aliases": [], "types": ["T044"], "canonical_name": "histone H2A phosphorylation", "definition": "The modification of histone H2A by the addition of a phosphate group. [GOC:mah, PMID:23080121]"}
{"concept_id": "C3824315", "aliases": ["single-strand break-containing damaged DNA binding", "SSB-containing DNA binding"], "types": ["T045"], "canonical_name": "single-strand break-containing DNA binding", "definition": "Binding to damaged DNA containing single-strand breaks (SSBs). [GOC:al, PMID:21984210]"}
{"concept_id": "C3824316", "aliases": ["protein localisation to site of double-strand break", "protein localization to double-strand break site", "protein localization to site of DSB"], "types": ["T043"], "canonical_name": "protein localization to site of double-strand break", "definition": "Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred. [GOC:mah, PMID:23080121]"}
{"concept_id": "C3824317", "aliases": [], "types": ["T044"], "canonical_name": "protein K27-linked deubiquitination", "definition": "A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein. [PMID:23827681]"}
{"concept_id": "C3824318", "aliases": [], "types": ["T044"], "canonical_name": "protein K33-linked deubiquitination", "definition": "A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein. [PMID:23827681]"}
{"concept_id": "C3824319", "aliases": ["response to copper ion stress"], "types": ["T040"], "canonical_name": "stress response to copper ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus. [GOC:kmv, PMID:23437011]"}
{"concept_id": "C3824320", "aliases": [], "types": ["T040"], "canonical_name": "response to copper toxicity"}
{"concept_id": "C3824321", "aliases": [], "types": ["T040"], "canonical_name": "stress response to copper"}
{"concept_id": "C3824322", "aliases": ["response to cadmium ion stress"], "types": ["T040"], "canonical_name": "stress response to cadmium ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus. [GOC:kmv]"}
{"concept_id": "C3824323", "aliases": [], "types": ["T040"], "canonical_name": "response to cadmium toxicity"}
{"concept_id": "C3824324", "aliases": [], "types": ["T040"], "canonical_name": "stress response to cadmium"}
{"concept_id": "C3824325", "aliases": [], "types": ["T044"], "canonical_name": "SCF complex disassembly in response to cadmium stress", "definition": "The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress. [GOC:rb, PMID:23000173]"}
{"concept_id": "C3824326", "aliases": ["G-protein coupled receptor catabolic process"], "types": ["T044"], "canonical_name": "G protein-coupled receptor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor. [PMID:12142540, PMID:23954414]"}
{"concept_id": "C3824327", "aliases": ["protein localisation to nucleoplasm"], "types": ["T043"], "canonical_name": "protein localization to nucleoplasm", "definition": "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm. [GOC:mah, PMID:22918952]"}
{"concept_id": "C3824328", "aliases": [], "types": ["T045"], "canonical_name": "phosphodiesterase decapping endonuclease activity", "definition": "Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA. [GOC:dgf, PMID:20802481]"}
{"concept_id": "C3824329", "aliases": [], "types": ["T045"], "canonical_name": "G(5')pppN pyrophosphatase activity"}
{"concept_id": "C3824330", "aliases": [], "types": ["T044"], "canonical_name": "EH domain binding", "definition": "Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R. [GOC:hjd, PMID:11911876, PMID:21115825]"}
{"concept_id": "C3824331", "aliases": ["MalF-MalG-MalK(2) complex location", "maltose transport complex location, core subunit", "MalFGK(2) complex", "MalF-MalG-MalK-MalK complex", "MalF-MalG-MalK(2) complex", "maltose transport complex, core subunit", "maltose transport MalFGK2 complex location", "MalFGK2 complex location", "MalF-MalG-MalK-MalK complex location", "maltose transport MalFGK2 complex", "MalFGK(2) complex location"], "types": ["T026"], "canonical_name": "MalFGK2 complex", "definition": "Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG. [GOC:bhm, PMID:19250913]"}
{"concept_id": "C3824332", "aliases": ["IHF complex location", "IHF-DNA complex location", "IHFa-IHFb-DNA complex", "IHF complex", "IHFa-IHFb-DNA complex location"], "types": ["T026"], "canonical_name": "IHF-DNA complex", "definition": "A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid. [GOC:bhm, PMID:17097674]"}
{"concept_id": "C3824333", "aliases": ["HU-DNA complex location"], "types": ["T026"], "canonical_name": "HU-DNA complex", "definition": "A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure. [GOC:bhm, PMID:17360520]"}
{"concept_id": "C3824334", "aliases": ["HU complex location"], "types": ["T026"], "canonical_name": "HU complex"}
{"concept_id": "C3824335", "aliases": ["protein localisation to actomyosin contractile ring"], "types": ["T043"], "canonical_name": "protein localization to actomyosin contractile ring", "definition": "A process in which a protein is transported to, or maintained at, the actomyosin contractile ring. [GOC:mah, PMID:23349808]"}
{"concept_id": "C3824336", "aliases": ["tRNA 3' processing in mitochondrion", "tRNA 3'-end processing in mitochondria", "tRNA 3' processing in mitochondria"], "types": ["T045"], "canonical_name": "mitochondrial tRNA 3'-end processing", "definition": "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion. [GOC:mah, GOC:TermGenie, PMID:23928301]"}
{"concept_id": "C3824337", "aliases": ["acetyl-CoA anabolism from pantothenate"], "types": ["T044"], "canonical_name": "acetyl-CoA biosynthetic process from pantothenate", "definition": "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA. [GOC:mah, PMID:23091701]"}
{"concept_id": "C3824338", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA formation from pantothenate"}
{"concept_id": "C3824339", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA synthesis from pantothenate"}
{"concept_id": "C3824340", "aliases": ["extracellular vesicular exosome secretion", "multi-vesicular body fusion with plasma membrane", "exosomal secretory pathway", "secretion of exosome"], "types": ["T043"], "canonical_name": "exosomal secretion", "definition": "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898]"}
{"concept_id": "C3824341", "aliases": [], "types": ["T043"], "canonical_name": "exosomal protein secretion"}
{"concept_id": "C3824342", "aliases": [], "types": ["T039"], "canonical_name": "lymphatic vascular process in circulatory system", "definition": "A circulatory process that occurs at the level of the lymphatic vasculature. [PMID:21576390]"}
{"concept_id": "C3824343", "aliases": ["amino acid transport complex location"], "types": ["T026"], "canonical_name": "amino acid transport complex", "definition": "A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane. [GOC:kmv, PMID:14668347]"}
{"concept_id": "C3824344", "aliases": [], "types": ["T039"], "canonical_name": "regulation of lymphatic vascular permeability", "definition": "Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid. [PMID:23897233]"}
{"concept_id": "C3824345", "aliases": [], "types": ["T038"], "canonical_name": "regulation of lymphatic vessel size", "definition": "Any process that modulates the size of lymphatic vessels. [PMID:23897233]"}
{"concept_id": "C3824346", "aliases": [], "types": ["T038"], "canonical_name": "regulation of collecting lymphatic vessel size"}
{"concept_id": "C3824348", "aliases": [], "types": ["T045"], "canonical_name": "euchromatin binding", "definition": "Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin. [GOC:vw, PMID:22431512]"}
{"concept_id": "C3824349", "aliases": [], "types": ["T044"], "canonical_name": "peptide-serine-N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide. [GOC:al, PMID:23912279]"}
{"concept_id": "C3824350", "aliases": [], "types": ["T044"], "canonical_name": "peptide-glutamate-N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide. [GOC:al, PMID:23912279]"}
{"concept_id": "C3824351", "aliases": ["cobalamin transport complex location", "vitamin B12-transporting BtuCDF complex location", "cobalamin-transporting BtuCDF complex", "vitamin B12 transport complex location", "BtuCDF complex location", "BtuCDF complex", "vitamin B12 transport complex", "cobalamin-transporting BtuCDF complex location", "vitamin B12-transporting BtuCDF complex"], "types": ["T026"], "canonical_name": "cobalamin transport complex", "definition": "Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD. [GOC:bhm, PMID:22569249]"}
{"concept_id": "C3824352", "aliases": ["lymphatic vessel myogenic constriction"], "types": ["T038"], "canonical_name": "collecting lymphatic vessel constriction", "definition": "A decrease in the diameter of collecting lymphatic vessels. [PMID:23322290]"}
{"concept_id": "C3824353", "aliases": ["BtuC-BtuD complex", "vitamin B12 transport complex location, core subunit", "vitamin B12 transport complex, core subunit", "BtuC-BtuD complex location", "cobalamin transport complex location, core subunit", "BtuCD complex location", "cobalamin transport complex, core subunit"], "types": ["T026"], "canonical_name": "BtuCD complex", "definition": "Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer. [GOC:bhm, PMID:22569249]"}
{"concept_id": "C3824354", "aliases": [], "types": ["T045"], "canonical_name": "cytoplasmic U snRNP body assembly", "definition": "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body. [PMID:19464282]"}
{"concept_id": "C3824355", "aliases": [], "types": ["T045"], "canonical_name": "U body assembly"}
{"concept_id": "C3824356", "aliases": ["macrolide transmembrane transporter complex location"], "types": ["T024"], "canonical_name": "macrolide transmembrane transporter complex", "definition": "A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes. [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725]"}
{"concept_id": "C3824357", "aliases": ["AcrAB-TolC complex location"], "types": ["T024"], "canonical_name": "AcrAB-TolC complex"}
{"concept_id": "C3824358", "aliases": ["MacAB-TolC complex location", "macrolide transporter MacAB-TolC complex", "macrolide transporter MacAB-TolC complex location", "MacAB-TolC complex"], "types": ["T024"], "canonical_name": "MacAB-TolC complex", "definition": "The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC. [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725]"}
{"concept_id": "C3824359", "aliases": [], "types": ["T024"], "canonical_name": "macrolide transporter"}
{"concept_id": "C3824360", "aliases": ["macrolide transporter complex location"], "types": ["T024"], "canonical_name": "macrolide transporter complex"}
{"concept_id": "C3824361", "aliases": ["ATP-binding cassette (ABC) methionine importer complex", "ATP-dependent methionine-importing complex", "ATP-dependent methionine importer complex", "ATP-dependent methionine importing complex", "ATP-dependent methionine-importing complex location", "ATP-dependent methionine importing complex location", "ATP-binding cassette (ABC) methionine importer complex location", "methionine-importing ABC transporter complex location", "ATP-dependent methionine importer complex location"], "types": ["T026"], "canonical_name": "methionine-importing ABC transporter complex", "definition": "An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner. [GOC:bhm, PMID:22095702]"}
{"concept_id": "C3824362", "aliases": ["methionine transport complex location"], "types": ["T026"], "canonical_name": "methionine transport complex"}
{"concept_id": "C3824363", "aliases": [], "types": ["T026"], "canonical_name": "methionine transporter"}
{"concept_id": "C3824364", "aliases": ["methionine transporter complex location"], "types": ["T026"], "canonical_name": "methionine transporter complex"}
{"concept_id": "C3824365", "aliases": ["methionine transporter complex location, ATP-dependent"], "types": ["T026"], "canonical_name": "methionine transporter complex, ATP-dependent"}
{"concept_id": "C3824366", "aliases": ["MetNI complex location"], "types": ["T026"], "canonical_name": "MetNI complex"}
{"concept_id": "C3824367", "aliases": ["MetNI transport complex location"], "types": ["T026"], "canonical_name": "MetNI transport complex"}
{"concept_id": "C3824368", "aliases": [], "types": ["T026"], "canonical_name": "MetNI transporter"}
{"concept_id": "C3824369", "aliases": ["MetNI transporter complex location"], "types": ["T026"], "canonical_name": "MetNI transporter complex"}
{"concept_id": "C3824370", "aliases": ["MetNIQ complex location"], "types": ["T026"], "canonical_name": "MetNIQ complex"}
{"concept_id": "C3824371", "aliases": ["MetNIQ transport complex location"], "types": ["T026"], "canonical_name": "MetNIQ transport complex"}
{"concept_id": "C3824372", "aliases": [], "types": ["T026"], "canonical_name": "MetNIQ transporter"}
{"concept_id": "C3824373", "aliases": ["MetNIQ transporter complex location"], "types": ["T026"], "canonical_name": "MetNIQ transporter complex"}
{"concept_id": "C3824374", "aliases": ["ModE dimer", "ModE complex location"], "types": ["T026"], "canonical_name": "ModE complex", "definition": "A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism. [GOC:bhm, PMID:12581638]"}
{"concept_id": "C3824375", "aliases": ["MsbA complex location", "MsbA complex", "MsbA dimer", "MsbA transporter complex location"], "types": ["T026"], "canonical_name": "MsbA transporter complex", "definition": "An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD). [GOC:bhm, PMID:18024585]"}
{"concept_id": "C3824376", "aliases": ["SsuD-SsuE complex location"], "types": ["T026"], "canonical_name": "SsuD-SsuE complex", "definition": "A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation. [GOC:bhm, PMID:16997955]"}
{"concept_id": "C3824377", "aliases": [], "types": ["T026"], "canonical_name": "two-component alkanesulfonate monooxygenase system"}
{"concept_id": "C3824378", "aliases": ["alkanesulfonate monooxygenase complex location"], "types": ["T026"], "canonical_name": "alkanesulfonate monooxygenase complex", "definition": "A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer. [GOC:bhm, PMID:10480865, PMID:16997955]"}
{"concept_id": "C3824379", "aliases": ["SsuD complex location"], "types": ["T026"], "canonical_name": "SsuD complex"}
{"concept_id": "C3824380", "aliases": ["FMN reductase complex location, NAD(P)H-dependent", "FMN reductase complex, NAD(P)H-dependent", "FMN reductase complex location"], "types": ["T026"], "canonical_name": "FMN reductase complex", "definition": "A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer. [GOC:bhm, PMID:10480865, PMID:16997955]"}
{"concept_id": "C3824381", "aliases": ["flavin oxidoreductase complex location, NAD(P)H-dependent"], "types": ["T026"], "canonical_name": "flavin oxidoreductase complex, NAD(P)H-dependent"}
{"concept_id": "C3824382", "aliases": ["FMN oxidoreductase complex location, NAD(P)H-dependent"], "types": ["T026"], "canonical_name": "FMN oxidoreductase complex, NAD(P)H-dependent"}
{"concept_id": "C3824383", "aliases": ["SsuE complex location"], "types": ["T026"], "canonical_name": "SsuE complex"}
{"concept_id": "C3824384", "aliases": ["multidrug efflux pump MdtBC"], "types": ["T026"], "canonical_name": "MdtBC Complex", "definition": "A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane. [GOC:bhm, PMID:20038594]"}
{"concept_id": "C3824385", "aliases": ["oxidoreductase complex location", "oxidation-reduction complex location", "oxidation-reduction complex", "redox complex", "redox complex location"], "types": ["T026"], "canonical_name": "oxidoreductase complex", "definition": "Any protein complex that possesses oxidoreductase activity. [GOC:bhm, PMID:18982432]"}
{"concept_id": "C3824386", "aliases": ["2-aminoethanesulfonate dioxygenase complex location", "alpha-ketoglutarate-dependent taurine dioxygenase complex location", "2-aminoethanesulfonate dioxygenase complex", "taurine dioxygenase complex location", "alpha-ketoglutarate-dependent taurine dioxygenase complex"], "types": ["T026"], "canonical_name": "taurine dioxygenase complex", "definition": "A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD. [GOC:bhm, PMID:12741810]"}
{"concept_id": "C3824387", "aliases": ["TauD complex location"], "types": ["T026"], "canonical_name": "TauD complex"}
{"concept_id": "C3824388", "aliases": [], "types": ["T044"], "canonical_name": "jasmonyl-Ile conjugate hydrolase activity", "definition": "Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine. [PMID:23943861]"}
{"concept_id": "C3824389", "aliases": [], "types": ["T044"], "canonical_name": "JA-Ile hydrolase"}
{"concept_id": "C3824390", "aliases": ["EmrE multidrug transporter complex location"], "types": ["T026"], "canonical_name": "EmrE multidrug transporter complex", "definition": "A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer. [GOC:bhm, PMID:18024586]"}
{"concept_id": "C3824391", "aliases": ["EmrE complex location"], "types": ["T026"], "canonical_name": "EmrE complex"}
{"concept_id": "C3824392", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of RNA levels in host", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:12182338, PMID:18703740]"}
{"concept_id": "C3824393", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of RNA levels in host", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:ml, PMID:18703740]"}
{"concept_id": "C3824394", "aliases": ["positive regulation by symbiont of auxin levels in host", "positive regulation by symbiont of IAA levels in host"], "types": ["T040"], "canonical_name": "positive regulation by symbiont of indole acetic acid levels in host", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:ml, PMID:18056646]"}
{"concept_id": "C3824395", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of jasmonic acid levels in host", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:ml, PMID:14617079, PMID:16553894]"}
{"concept_id": "C3824396", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of ethylene levels in host", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:ml, PMID:16167902]"}
{"concept_id": "C3824397", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of salicylic acid levels in host", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:ml, PMID:17722699, PMID:20565685]"}
{"concept_id": "C3824399", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by symbiont of host intracellular transport", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of intracellular transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:22319451]"}
{"concept_id": "C3824400", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host transcription", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of transcription in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:21994350]"}
{"concept_id": "C3824401", "aliases": ["negative regulation by symbiont of host phytoalexin production"], "types": ["T040"], "canonical_name": "suppression by symbiont of host phytoalexin production", "definition": "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:21402357]"}
{"concept_id": "C3824402", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of abscisic acid levels in host", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the abscisic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:17304219]"}
{"concept_id": "C3824404", "aliases": ["GroEL-GroES complex location"], "types": ["T026"], "canonical_name": "GroEL-GroES complex", "definition": "Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins. [GOC:bhm, PMID:15313620]"}
{"concept_id": "C3824405", "aliases": ["bacterial chaperonin ATPase complex location"], "types": ["T026"], "canonical_name": "bacterial chaperonin ATPase complex"}
{"concept_id": "C3824406", "aliases": ["bacterial chaperonin complex location"], "types": ["T026"], "canonical_name": "bacterial chaperonin complex"}
{"concept_id": "C3824407", "aliases": ["SufS complex location"], "types": ["T026"], "canonical_name": "SufS complex"}
{"concept_id": "C3824408", "aliases": ["ATP-binding cassette (ABC) transporter complex ProVWX", "ATP-binding cassette (ABC) transporter complex ProVWX location", "ProVWX complex location"], "types": ["T026"], "canonical_name": "ProVWX complex", "definition": "The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions. [GOC:bhm, PMID:23249124]"}
{"concept_id": "C3824409", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of cytokinin levels in host", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the cytokinin levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:24124900]"}
{"concept_id": "C3824410", "aliases": ["beta-nicotinamide D-ribonucleotide phosphatase activity", "nicotinamide mononucleotide phosphatase activity"], "types": ["T044"], "canonical_name": "NMN phosphatase activity", "definition": "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate. [GOC:rb, PMID:21349851, RHEA:30815]"}
{"concept_id": "C3824411", "aliases": [], "types": ["T026"], "canonical_name": "rhoptry neck", "definition": "Narrow, electron-dense part of the rhoptry that extends through the conoid at the apical tip of an apicomplexan parasite. The rhoptry neck serves as a duct through which the contents of the rhoptry are secreted after attachment to the host has been completed and at the commencement of invasion. [GOC:giardia, GOC:pr, PMID:23499754, PMID:23937520, PMID:24002067, PMID:24070999]"}
{"concept_id": "C3824412", "aliases": [], "types": ["T044"], "canonical_name": "histone methyltransferase binding", "definition": "Binding to a histone methyltransferase enzyme. [GOC:ame, GOC:BHF, PMID:19486527]"}
{"concept_id": "C3824413", "aliases": ["paranodal axoglial junction maintenance", "axoglial septate junction maintenance", "paranodal septate maintenance"], "types": ["T043"], "canonical_name": "paranodal junction maintenance", "definition": "The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. [GOC:pr, PMID:24011083]"}
{"concept_id": "C3824414", "aliases": ["sulfurtransferase complex location", "sulfur transfer complex location", "sulfur transfer complex"], "types": ["T026"], "canonical_name": "sulfurtransferase complex", "definition": "A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor). [GOC:bhm, PMID:17350958]"}
{"concept_id": "C3824415", "aliases": ["SufE complex location"], "types": ["T026"], "canonical_name": "SufE complex"}
{"concept_id": "C3824416", "aliases": [], "types": ["T026"], "canonical_name": "SufE dimer"}
{"concept_id": "C3824417", "aliases": ["iron-sulfur cluster assembly complex location"], "types": ["T026"], "canonical_name": "iron-sulfur cluster assembly complex", "definition": "A protein complex capable of assembling an iron-sulfur (Fe-S) cluster. [GOC:bhm, PMID:17350958]"}
{"concept_id": "C3824418", "aliases": ["Fe-S cluster assembly complex location"], "types": ["T026"], "canonical_name": "Fe-S cluster assembly complex"}
{"concept_id": "C3824419", "aliases": ["SufBCD complex location"], "types": ["T026"], "canonical_name": "SufBCD complex"}
{"concept_id": "C3824420", "aliases": ["Fe-S cluster transfer complex", "Fe-S cluster transfer complex location", "iron-sulfur cluster transfer complex location"], "types": ["T026"], "canonical_name": "iron-sulfur cluster transfer complex", "definition": "A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor). [GOC:bhm, PMID:19810706]"}
{"concept_id": "C3824421", "aliases": ["IscA complex location"], "types": ["T026"], "canonical_name": "IscA complex"}
{"concept_id": "C3824422", "aliases": ["SufA complex location"], "types": ["T026"], "canonical_name": "SufA complex"}
{"concept_id": "C3824423", "aliases": [], "types": ["T026"], "canonical_name": "SufA dimer"}
{"concept_id": "C3824424", "aliases": ["stimulator of interferon genes complex location", "stimulator of interferon genes complex", "STING complex location"], "types": ["T026"], "canonical_name": "STING complex", "definition": "A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response. [GOC:bhm, PMID:22705373, PMID:23706668, PMID:23910378]"}
{"concept_id": "C3824425", "aliases": ["phosphomannomutase complex location"], "types": ["T026"], "canonical_name": "phosphomannomutase complex", "definition": "A protein complex capable of phosphomannomutase activity. [GOC:bhm, PMID:16540464]"}
{"concept_id": "C3824426", "aliases": ["PMM-1 complex location"], "types": ["T026"], "canonical_name": "PMM-1 complex"}
{"concept_id": "C3824427", "aliases": [], "types": ["T026"], "canonical_name": "PMM-1 dimer"}
{"concept_id": "C3824428", "aliases": ["PMM-2 complex location"], "types": ["T026"], "canonical_name": "PMM-2 complex"}
{"concept_id": "C3824429", "aliases": [], "types": ["T026"], "canonical_name": "PMM-2 dimer"}
{"concept_id": "C3824430", "aliases": ["intramolecular phosphotransferase complex location"], "types": ["T026"], "canonical_name": "intramolecular phosphotransferase complex", "definition": "A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule. [GOC:bhm, PMID:16540464]"}
{"concept_id": "C3824431", "aliases": ["transferase complex location"], "types": ["T026"], "canonical_name": "transferase complex", "definition": "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). [GOC:bhm, PMID:16540464]"}
{"concept_id": "C3824432", "aliases": ["diamine N-acetyltransferase complex location"], "types": ["T026"], "canonical_name": "diamine N-acetyltransferase complex", "definition": "A protein complex which is capable of diamine N-acetyltransferase activity. [GOC:bhm, PMID:8077207]"}
{"concept_id": "C3824433", "aliases": ["SAT complex location"], "types": ["T026"], "canonical_name": "SAT complex"}
{"concept_id": "C3824434", "aliases": [], "types": ["T026"], "canonical_name": "SAT tetramer"}
{"concept_id": "C3824435", "aliases": ["spermidine acetyltransferase complex location"], "types": ["T026"], "canonical_name": "spermidine acetyltransferase complex"}
{"concept_id": "C3824436", "aliases": [], "types": ["T043"], "canonical_name": "proteasome core complex import into nucleus", "definition": "The directed movement of the proteasome core complex (AKA core particle (CP)) from the cytoplasm into the nucleus. [GOC:dos, GOC:rb, PMID:23982732]"}
{"concept_id": "C3824438", "aliases": [], "types": ["T045"], "canonical_name": "double-stranded DNA endodeoxyribonuclease activity", "definition": "Catalysis of the hydrolysis of ester linkages within a double-stranded deoxyribonucleic acid molecule by creating internal breaks. [GOC:PG, PMID:22885404]"}
{"concept_id": "C3824439", "aliases": [], "types": ["T045"], "canonical_name": "dsDNA-specific endodeoxyribonuclease activity"}
{"concept_id": "C3824440", "aliases": [], "types": ["T044"], "canonical_name": "steroid hormone binding", "definition": "Binding to a steroid hormone. [GOC:ln]"}
{"concept_id": "C3824445", "aliases": ["atf1-pcr1 complex location"], "types": ["T026"], "canonical_name": "atf1-pcr1 complex", "definition": "A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE). [PMID:24224056]"}
{"concept_id": "C3824446", "aliases": ["histone threonine kinase activity (H2A-T120 specific)"], "types": ["T044"], "canonical_name": "histone kinase activity (H2A-T120 specific)", "definition": "Catalysis of the transfer of a phosphate group to the threonine-120 residue of histone H2A. [PMID:24140421]"}
{"concept_id": "C3824447", "aliases": ["histone H2AT120 phosphorylation", "histone H2A phosphorylation at T120"], "types": ["T044"], "canonical_name": "histone H2A-T120 phosphorylation", "definition": "The modification of histone H2A by the addition of a phosphate group to a threonine residue at position 120 of the histone. [PMID:24140421]"}
{"concept_id": "C3824448", "aliases": ["mitochondrial uniporter complex", "mitochondrial uniporter complex location", "uniplex complex location", "mitochondrial uniporter holocomplex", "mitochondrial uniporter holocomplex location"], "types": ["T026"], "canonical_name": "uniplex complex", "definition": "A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE. [PMID:24231807]"}
{"concept_id": "C3824449", "aliases": [], "types": ["T045"], "canonical_name": "N6-methyladenosine-containing RNA binding", "definition": "Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. [PMID:22575960, PMID:24284625]"}
{"concept_id": "C3824450", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transcription from RNA polymerase II promoter in response to DNA damage", "definition": "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage. [PMID:15660129]"}
{"concept_id": "C3824451", "aliases": ["nucleotide-excision repair, DNA damage recognition complex location"], "types": ["T026"], "canonical_name": "nucleotide-excision repair, DNA damage recognition complex", "definition": "A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex. [GOC:bhm, PMID:22331906]"}
{"concept_id": "C3824452", "aliases": ["transcription-coupled nucleotide-excision repair, DNA damage recognition complex location"], "types": ["T026"], "canonical_name": "transcription-coupled nucleotide-excision repair, DNA damage recognition complex", "definition": "A protein complex that is capable of identifying lesions in DNA on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex. [GOC:bhm, PMID:22331906]"}
{"concept_id": "C3824454", "aliases": ["Mmi1 nuclear focus"], "types": ["T026"], "canonical_name": "nuclear exosome focus", "definition": "An nuclear body involved in nuclear mRNA surveilllance. Contains at least Mmi1, or an ortholog of it, and the nuclear exosome. [GOC:al, GOC:vw, PMID:16823445, PMID:23980030, PMID:32012158]"}
{"concept_id": "C3824455", "aliases": ["Syp1 complex location", "Syp1 dimer"], "types": ["T026"], "canonical_name": "Syp1 complex", "definition": "A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis. [GOC:bhm, PMID:19713939]"}
{"concept_id": "C3824456", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to leucine starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine. [PMID:19033384]"}
{"concept_id": "C3824457", "aliases": [], "types": ["T044"], "canonical_name": "keratin filament binding", "definition": "Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. [GOC:krc, PMID:6170061]"}
{"concept_id": "C3824458", "aliases": [], "types": ["T043"], "canonical_name": "subsynaptic reticulum organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a subsynaptic reticulum. A subsynaptic reticulum is an elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane. [PMID:21041451]"}
{"concept_id": "C3824459", "aliases": [], "types": ["T044"], "canonical_name": "signal clustering", "definition": "Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response. [GOC:als, PMID:12011072, PMID:15603739]"}
{"concept_id": "C3824460", "aliases": [], "types": ["T044"], "canonical_name": "ligand clustering"}
{"concept_id": "C3824461", "aliases": [], "types": ["T044"], "canonical_name": "histone glutamine methylation", "definition": "The modification of a histone by addition of a methyl group to an glutamine residue. [PMID:24352239]"}
{"concept_id": "C3824462", "aliases": [], "types": ["T044"], "canonical_name": "histone-glutamine methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-glutamine = S-adenosyl-L-homocysteine + (histone)-N5-methyl-glutamine. [PMID:24352239]"}
{"concept_id": "C3824463", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter using a mechanism that involves the localization of a transcription factor and initiated in response to the DNA damage checkpoint signaling. [PMID:24006488]"}
{"concept_id": "C3824464", "aliases": ["pre-mRNA decay", "unspliced RNA decay"], "types": ["T045"], "canonical_name": "pre-mRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA). [GOC:rb, PMID:22844259]"}
{"concept_id": "C3824465", "aliases": [], "types": ["T044"], "canonical_name": "anti-Mullerian hormone signaling pathway", "definition": "The series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:hjd, PMID:23624077]"}
{"concept_id": "C3824466", "aliases": ["MAPK cascade in response to starvation", "MAPK cascade involved in nutrient response signaling"], "types": ["T043"], "canonical_name": "spore wall assembly MAPK cascade", "definition": "A MAPK cascade that occurs as a result of deprivation of nourishment. [GOC:al, PMID:7501024]"}
{"concept_id": "C3824467", "aliases": [], "types": ["T040"], "canonical_name": "peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity", "definition": "Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity. [PMID:7501024]"}
{"concept_id": "C3824468", "aliases": ["platelet-derived growth factor complex location"], "types": ["T026"], "canonical_name": "platelet-derived growth factor complex", "definition": "A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD). [GOC:bhm, PMID:11331882]"}
{"concept_id": "C3824469", "aliases": ["PDGF complex location", "PDGF complex"], "types": ["T026"], "canonical_name": "PDGF complex"}
{"concept_id": "C3824470", "aliases": [], "types": ["T026"], "canonical_name": "PDGF-AA dimer"}
{"concept_id": "C3824471", "aliases": [], "types": ["T026"], "canonical_name": "PDGF-AB dimer"}
{"concept_id": "C3824472", "aliases": [], "types": ["T026"], "canonical_name": "PDGF-BB dimer"}
{"concept_id": "C3824473", "aliases": [], "types": ["T026"], "canonical_name": "PDGF-CC dimer"}
{"concept_id": "C3824474", "aliases": [], "types": ["T026"], "canonical_name": "PDGF-DD dimer"}
{"concept_id": "C3824475", "aliases": [], "types": ["T043"], "canonical_name": "response to transition metal nanoparticle", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle. [PMID:23150627]"}
{"concept_id": "C3824476", "aliases": [], "types": ["T043"], "canonical_name": "response to colloidal metal"}
{"concept_id": "C3824477", "aliases": [], "types": ["T043"], "canonical_name": "response to neutral metal atoms"}
{"concept_id": "C3824478", "aliases": [], "types": ["T043"], "canonical_name": "response to gold nanoparticle", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus. [PMID:23150627]"}
{"concept_id": "C3824479", "aliases": ["RNAP II C-terminal domain phosphoserine binding", "RNA Pol II C-terminal domain phosphoserine binding"], "types": ["T044"], "canonical_name": "RNA polymerase II C-terminal domain phosphoserine binding", "definition": "Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II. [GOC:di, PMID:22796944]"}
{"concept_id": "C3824480", "aliases": ["PDGF receptor-ligand complex location", "PDGF receptor-ligand complex", "platelet-derived growth factor receptor-ligand complex location"], "types": ["T026"], "canonical_name": "platelet-derived growth factor receptor-ligand complex", "definition": "A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes. [GOC:bhm, PMID:11331882]"}
{"concept_id": "C3824481", "aliases": ["PDGF-AA-receptor alpha complex location"], "types": ["T026"], "canonical_name": "PDGF-AA-receptor alpha complex"}
{"concept_id": "C3824482", "aliases": ["PDGF-AB-receptor alpha complex location"], "types": ["T026"], "canonical_name": "PDGF-AB-receptor alpha complex"}
{"concept_id": "C3824483", "aliases": ["PDGF-AB-receptor beta complex location"], "types": ["T026"], "canonical_name": "PDGF-AB-receptor beta complex"}
{"concept_id": "C3824484", "aliases": ["PDGF-BB-receptor alpha complex location"], "types": ["T026"], "canonical_name": "PDGF-BB-receptor alpha complex"}
{"concept_id": "C3824485", "aliases": ["PDGF-BB-receptor alpha-beta complex location"], "types": ["T026"], "canonical_name": "PDGF-BB-receptor alpha-beta complex"}
{"concept_id": "C3824486", "aliases": ["PDGF-BB-receptor beta complex location"], "types": ["T026"], "canonical_name": "PDGF-BB-receptor beta complex"}
{"concept_id": "C3824487", "aliases": ["PDGF-CC-receptor alpha complex location"], "types": ["T026"], "canonical_name": "PDGF-CC-receptor alpha complex"}
{"concept_id": "C3824488", "aliases": ["PDGF-CC-receptor alpha-beta complex location"], "types": ["T026"], "canonical_name": "PDGF-CC-receptor alpha-beta complex"}
{"concept_id": "C3824489", "aliases": ["PDGF-CC-receptor beta complex location"], "types": ["T026"], "canonical_name": "PDGF-CC-receptor beta complex"}
{"concept_id": "C3824490", "aliases": ["PDGF-DD-receptor alpha-beta complex location"], "types": ["T026"], "canonical_name": "PDGF-DD-receptor alpha-beta complex"}
{"concept_id": "C3824491", "aliases": ["PDGF-DD-receptor beta complex location"], "types": ["T026"], "canonical_name": "PDGF-DD-receptor beta complex"}
{"concept_id": "C3824492", "aliases": ["receptor-ligand complex location"], "types": ["T026"], "canonical_name": "receptor-ligand complex"}
{"concept_id": "C3824493", "aliases": [], "types": ["T044"], "canonical_name": "anti-Mullerian hormone receptor activity", "definition": "Combining with anti-Mullerian hormone to initiate a change in cell activity. [GOC:hjd, PMID:23624077]"}
{"concept_id": "C3824494", "aliases": [], "types": ["T044"], "canonical_name": "snRNA 5'-end processing"}
{"concept_id": "C3824495", "aliases": ["mitotic CAR disassembly", "mitotic contractile actomyosin ring disassembly"], "types": ["T043"], "canonical_name": "mitotic actomyosin contractile ring disassembly", "definition": "Any disaggregation of an actomyosin contractile ring into its constituent components that is involved in a mitotic cell cycle. [PMID:14602073, PMID:22891673]"}
{"concept_id": "C3824496", "aliases": [], "types": ["T043"], "canonical_name": "mitotic actomyosin ring disassembly"}
{"concept_id": "C3824497", "aliases": [], "types": ["T043"], "canonical_name": "mitotic constriction ring disassembly"}
{"concept_id": "C3824498", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cytokinetic ring disassembly"}
{"concept_id": "C3824499", "aliases": [], "types": ["T044"], "canonical_name": "preribosome binding", "definition": "Binding to a preribosome. [GOC:di, PMID:22735702]"}
{"concept_id": "C3824500", "aliases": [], "types": ["T044"], "canonical_name": "RNA 5'-methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule. [GOC:al, GOC:vw, PMID:22740346]"}
{"concept_id": "C3824503", "aliases": ["RNA localisation to chromatin"], "types": ["T043"], "canonical_name": "RNA localization to chromatin", "definition": "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. [GOC:dos, GOC:mah, PMID:22582262]"}
{"concept_id": "C3824504", "aliases": ["efflux transmembrane transporter complex", "efflux pump complex location", "efflux pump", "efflux transmembrane transporter complex location"], "types": ["T024"], "canonical_name": "efflux pump complex", "definition": "A protein complex that is capable of efflux transmembrane transporter activity. [GOC:dos, PMID:21556065, PMID:9417051]"}
{"concept_id": "C3824505", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine trans-autophosphorylation", "definition": "The phosphorylation of a peptidyl-threonine to form peptidyl-O-phospho-L-threonine on an identical protein. For example, phosphorylation by the other kinase within a homodimer. [PMID:19357077]"}
{"concept_id": "C3824507", "aliases": [], "types": ["T039"], "canonical_name": "renal amino acid absorption", "definition": "A renal system process in which amino acids are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:hjd, PMID:1526373]"}
{"concept_id": "C3824508", "aliases": ["bub1-bub3 complex location"], "types": ["T026"], "canonical_name": "bub1-bub3 complex", "definition": "Protein complex that associates with the kinetochores. [PMID:22521786]"}
{"concept_id": "C3824509", "aliases": [], "types": ["T043"], "canonical_name": "Bub1-Bub3 complex localization to kinetochore", "definition": "A cellular protein complex localization that acts on a Bub1-Bub3 complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. [PMID:22521786]"}
{"concept_id": "C3824510", "aliases": [], "types": ["T044"], "canonical_name": "cellulosome binding", "definition": "Binding to a cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides. [GOC:mengo_curators, PMID:11893054, PMID:15197390]"}
{"concept_id": "C3824512", "aliases": ["Bre1-Rad6 complex", "Bre1-Rad6 complex location", "Bre1-Rad6 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "Bre1-Rad6 ubiquitin ligase complex", "definition": "A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis. [GOC:bhm, PMID:19531475]"}
{"concept_id": "C3824513", "aliases": ["UBR1-RAD6 complex", "UBR1-RAD6 ubiquitin ligase complex location", "UBR1-RAD6 complex location"], "types": ["T026"], "canonical_name": "UBR1-RAD6 ubiquitin ligase complex", "definition": "A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. [GOC:bhm, PMID:19531475]"}
{"concept_id": "C3824514", "aliases": ["MUB1-RAD6-UBR2 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "MUB1-RAD6-UBR2 ubiquitin ligase complex", "definition": "A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme. [GOC:bhm, PMID:18070918]"}
{"concept_id": "C3824515", "aliases": ["RAD6-UBR2 complex", "RAD6-UBR2 complex location", "RAD6-UBR2 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "RAD6-UBR2 ubiquitin ligase complex", "definition": "A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation. [GOC:bhm, PMID:15504724]"}
{"concept_id": "C3824516", "aliases": ["RSP5-BUL1 complex", "RSP5-BUL1 complex location", "RSP5-BUL ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "RSP5-BUL ubiquitin ligase complex", "definition": "A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation. [GOC:bhm, PMID:9931424]"}
{"concept_id": "C3824517", "aliases": ["RSP5-BUL2 complex location"], "types": ["T026"], "canonical_name": "RSP5-BUL2 complex"}
{"concept_id": "C3824518", "aliases": [], "types": ["T044"], "canonical_name": "type-I dockerin domain binding", "definition": "Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain. [GOC:mengo_curators, PMID:23195689, PMID:24080387]"}
{"concept_id": "C3824519", "aliases": [], "types": ["T044"], "canonical_name": "type-II dockerin domain binding", "definition": "Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain. [GOC:mengo_curators, PMID:23195689, PMID:24080387]"}
{"concept_id": "C3824520", "aliases": [], "types": ["T044"], "canonical_name": "type-III dockerin domain binding", "definition": "Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain. [GOC:mengo_curators, PMID:23195689, PMID:24080387]"}
{"concept_id": "C3824521", "aliases": [], "types": ["T044"], "canonical_name": "type-I cohesin domain binding", "definition": "Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain. [GOC:mengo_curators, PMID:23195689, PMID:24080387]"}
{"concept_id": "C3824522", "aliases": [], "types": ["T044"], "canonical_name": "type-II cohesin domain binding", "definition": "Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain. [GOC:mengo_curators, PMID:23195689, PMID:24080387]"}
{"concept_id": "C3824523", "aliases": [], "types": ["T044"], "canonical_name": "type-III cohesin domain binding", "definition": "Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain. [GOC:mengo_curators, PMID:23195689, PMID:24080387]"}
{"concept_id": "C3824524", "aliases": ["cellular response to insulin-like growth factor"], "types": ["T043"], "canonical_name": "cellular response to insulin-like growth factor stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus. [PMID:20042609]"}
{"concept_id": "C3824525", "aliases": ["Mcs4 RR-MAPKKK complex location"], "types": ["T026"], "canonical_name": "Mcs4 RR-MAPKKK complex", "definition": "A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress. [PMID:24255738]"}
{"concept_id": "C3824526", "aliases": ["ULK1 signaling complex", "ATG1 kinase complex location", "autophagy-initiation complex", "ULK1 complex location", "autophagy-initiation complex location", "ATG1-ATG13 complex location", "ULK1-ATG13-FIP200 complex", "ATG1 kinase complex", "ULK1-ATG13-RB1CC1 complex", "ATG1/ULK1 signaling complex location", "Atg1p signalling complex location", "ATG1/ULK1 signaling complex", "ULK1-ATG13-RB1CC1 complex location", "ULK complex location", "ULK1-ATG13-FIP200 complex location", "ULK complex", "ULK1 complex", "ATG1-ATG13 complex", "ULK1 signaling complex location", "Atg1p signalling complex", "Atg1/ULK1 kinase complex location"], "types": ["T026"], "canonical_name": "Atg1/ULK1 kinase complex", "definition": "A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]"}
{"concept_id": "C3824527", "aliases": ["Gin4 complex location", "Gin4-septin complex location", "Gin4-septin complex"], "types": ["T026"], "canonical_name": "Gin4 complex", "definition": "A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved. [GOC:bhm, PMID:12058072]"}
{"concept_id": "C3824528", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XIX trimer", "definition": "A collagen homotrimer of alpha1(XIX) chains; type XIX collagen triple helices localize to basement membrane zones in differentiating muscle cells. [GOC:bhm, PMID:17876790]"}
{"concept_id": "C3824529", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XX trimer", "definition": "A collagen homotrimer of alpha1(XX) chains. [GOC:bhm, PMID:17876790]"}
{"concept_id": "C3824530", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XXI trimer", "definition": "A collagen homotrimer of alpha1(XXI) chains; type XXI collagen triple helices found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle. [GOC:bhm, PMID:17876790]"}
{"concept_id": "C3824531", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XXII trimer", "definition": "A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. [GOC:bhm, PMID:17876790]"}
{"concept_id": "C3824532", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XXIII trimer", "definition": "A collagen homotrimer of alpha1(XXIII) chains; type XXIII collagen triple helices span the plasma membrane. [GOC:bhm, PMID:17876790]"}
{"concept_id": "C3824533", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XXIV trimer", "definition": "A collagen homotrimer of alpha1(XXIV) chains; type XXIV collagen triple helices may participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. [GOC:bhm, PMID:17876790]"}
{"concept_id": "C3824534", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XXVI trimer", "definition": "A collagen homotrimer of alpha1(XXVI) chains. [GOC:bhm, PMID:17876790]"}
{"concept_id": "C3824535", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XXVII trimer", "definition": "A collagen homotrimer of alpha1(XXVII) chains. These trimers form thin, non-striated fibrils. Type XXVII collagen triple helices play a role during the calcification of cartilage and the transition of cartilage to bone. [GOC:bhm, PMID:17876790, PMID:21421911]"}
{"concept_id": "C3824536", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XXVIII trimer", "definition": "A collagen homotrimer of alpha1(XXVIII) chains. [GOC:bhm, PMID:17876790]"}
{"concept_id": "C3824537", "aliases": [], "types": ["T026"], "canonical_name": "collagen type XXV trimer", "definition": "A collagen homotrimer of alpha1(XXV) chains; type XXV collagen triple helices span the plasma membrane. [GOC:bhm, PMID:17876790]"}
{"concept_id": "C3824538", "aliases": ["RNA polymerase II, RPB4-RPB7 subcomplex location"], "types": ["T026"], "canonical_name": "RNA polymerase II, RPB4-RPB7 subcomplex"}
{"concept_id": "C3824539", "aliases": ["IscS-TusA complex location"], "types": ["T026"], "canonical_name": "IscS-TusA complex", "definition": "A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups. [GOC:bhm, PMID:20404999]"}
{"concept_id": "C3824540", "aliases": ["IscS-IscU complex location"], "types": ["T026"], "canonical_name": "IscS-IscU complex", "definition": "A heterotetrameric protein complex involved in the sulfur transfer during iron-sulfur cluster assembly and in the modification of tRNA wobble positions. In E. coli it consisting of a central IscS dimer with the IscU protomers attached to one of the IscS units each via a disulfide (-SSH) group. [GOC:bhm, PMID:20404999]"}
{"concept_id": "C3824541", "aliases": ["Hpa2 acetyltransferase complex location"], "types": ["T026"], "canonical_name": "Hpa2 acetyltransferase complex", "definition": "A tetrameric protein complex capable of acetyltransferase activity. It can catalyze the transfer of an acetyl group from acetyl-CoA to an acceptor residue on histone H-3, histone H-4, or on polyamines. The complex is also capable of acetylating certain small basic proteins. The two Hpa2 dimers that make up the tetramer are held together by interactions between the bound acetyl-CoA molecules. [GOC:bhm, PMID:10600387]"}
{"concept_id": "C3824542", "aliases": ["IRE1 dimer", "Ire1 complex location"], "types": ["T026"], "canonical_name": "Ire1 complex", "definition": "A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript. [GOC:bf, GOC:bhm, PMID:18191223, PMID:25437541]"}
{"concept_id": "C3824543", "aliases": ["mitotic checkpoint complex, CDC20-MAD2 subcomplex location", "CDC20-MAD2 complex", "CDC20-MAD2 complex location"], "types": ["T026"], "canonical_name": "mitotic checkpoint complex, CDC20-MAD2 subcomplex", "definition": "A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20. [GOC:bhm, PMID:15879521]"}
{"concept_id": "C3824544", "aliases": ["Bfa1-Bub2 complex location"], "types": ["T026"], "canonical_name": "Bfa1-Bub2 complex", "definition": "A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation. [GOC:bhm, PMID:16449187]"}
{"concept_id": "C3824545", "aliases": [], "types": ["T040"], "canonical_name": "process resulting in tolerance to alcohol"}
{"concept_id": "C3824546", "aliases": [], "types": ["T040"], "canonical_name": "process resulting in tolerance to butan-1-ol"}
{"concept_id": "C3824547", "aliases": [], "types": ["T040"], "canonical_name": "process resulting in tolerance to isobutanol"}
{"concept_id": "C3824548", "aliases": ["laminin-423", "laminin-14 complex location"], "types": ["T026"], "canonical_name": "laminin-14 complex", "definition": "A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains. [GOC:bhm, GOC:dph, PMID:15979864, PMID:17453709]"}
{"concept_id": "C3824549", "aliases": ["laminin-522", "laminin-522 complex location"], "types": ["T026"], "canonical_name": "laminin-522 complex", "definition": "A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains. [GOC:bhm, GOC:dph, PMID:15979864, PMID:17453709]"}
{"concept_id": "C3824550", "aliases": ["laminin-15 complex location", "laminin-523"], "types": ["T026"], "canonical_name": "laminin-15 complex", "definition": "A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains. [GOC:bhm, PMID:17453709]"}
{"concept_id": "C3824551", "aliases": ["thrombospondin complex location"], "types": ["T026"], "canonical_name": "thrombospondin complex", "definition": "A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour. [GOC:bhm, PMID:18193164]"}
{"concept_id": "C3824552", "aliases": [], "types": ["T026"], "canonical_name": "heterochromatin island", "definition": "A region of facultative heterochromatin formed dynamically at specific loci in response to environmental signals, independently of RNAi. [PMID:22144463, PMID:24210919]"}
{"concept_id": "C3824553", "aliases": [], "types": ["T043"], "canonical_name": "secondary cell septum biogenesis", "definition": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division. [PMID:22891259]"}
{"concept_id": "C3824555", "aliases": ["BID-BCL-xl complex location"], "types": ["T026"], "canonical_name": "BID-BCL-xl complex", "definition": "A heterodimeric protein complex consisting of BID and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. [GOC:bhm, PMID:14634621]"}
{"concept_id": "C3824557", "aliases": [], "types": ["T043"], "canonical_name": "gap junction-mediated intercellular transport", "definition": "The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells. [GOC:hjd, PMID:14506308, PMID:23261543, Wikipedia:Gap_junction]"}
{"concept_id": "C3824558", "aliases": ["glucose transporter complex location"], "types": ["T026"], "canonical_name": "glucose transporter complex", "definition": "A protein complex facilitating glucose transport into, out of or within a cell, or between cells. [GOC:bhm, PMID:15449578]"}
{"concept_id": "C3824559", "aliases": ["transporter complex location"], "types": ["T026"], "canonical_name": "transporter complex", "definition": "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. [GOC:bhm, PMID:15449578]"}
{"concept_id": "C3824560", "aliases": ["BRE1 E3 ubiquitin ligase complex location", "BRE1 oligomer", "BRE1 E3 ubiquitin-protein ligase complex", "BRE1 E3 ubiquitin-protein ligase complex location"], "types": ["T026"], "canonical_name": "BRE1 E3 ubiquitin ligase complex", "definition": "A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes. [GOC:bhm, PMID:19531475]"}
{"concept_id": "C3824561", "aliases": ["Fused-Smurf ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "Fused-Smurf ubiquitin ligase complex", "definition": "A ubiquitin ligase complex. In D. melanogaster, it regulates ubiquitination and proteolysis of the BMP receptor Thickveins in cystoblasts, potentially by controlling Tkv ubiquitination and degradation. [GOC:bhm, PMID:21145463]"}
{"concept_id": "C3824562", "aliases": ["activated SUMO-E1 ligase complex location"], "types": ["T026"], "canonical_name": "activated SUMO-E1 ligase complex", "definition": "A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins. [GOC:bhm, PMID:15660128]"}
{"concept_id": "C3824563", "aliases": ["SUMO-SAE1/2 complex location"], "types": ["T026"], "canonical_name": "SUMO-SAE1/2 complex"}
{"concept_id": "C3824564", "aliases": [], "types": ["T044"], "canonical_name": "L-methionine salvage from methionine sulphoxide", "definition": "The generation of L-methionine from methionine sulphoxide. [PMID:24118096]"}
{"concept_id": "C3824565", "aliases": [], "types": ["T044"], "canonical_name": "methionine salvage from methionine sulphoxide"}
{"concept_id": "C3824566", "aliases": ["sumoylated E2 ligase complex location"], "types": ["T026"], "canonical_name": "sumoylated E2 ligase complex", "definition": "A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase. [GOC:bhm, PMID:18691969]"}
{"concept_id": "C3824567", "aliases": [], "types": ["T026"], "canonical_name": "terminal web", "definition": "An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells. [GOC:kmv, PMID:19437512, PMID:24677443, PMID:7511618, Wikipedia:Terminal_web]"}
{"concept_id": "C3824568", "aliases": ["xylanolytic complex location", "xylanolytic complex"], "types": ["T026"], "canonical_name": "xylanosome", "definition": "A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose. [GOC:mengo_curators, PMID:16769147]"}
{"concept_id": "C3824569", "aliases": ["response to zinc ion stress"], "types": ["T043"], "canonical_name": "stress response to zinc ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a zinc ion stimulus. [GOC:kmv, pmid:17888400]"}
{"concept_id": "C3824570", "aliases": [], "types": ["T043"], "canonical_name": "response to zinc toxicity"}
{"concept_id": "C3824571", "aliases": [], "types": ["T043"], "canonical_name": "stress response to zinc"}
{"concept_id": "C3824572", "aliases": ["PKM2-SAICAR protein kinase complex location", "PKM2-SAICAR complex", "PKM2-SAICAR complex location"], "types": ["T026"], "canonical_name": "PKM2-SAICAR protein kinase complex"}
{"concept_id": "C3824573", "aliases": ["PKM2 pyruvate kinase complex location", "PKM2 homotetramer"], "types": ["T026"], "canonical_name": "PKM2 pyruvate kinase complex", "definition": "A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013). [GOC:bhm, PMID:24606918]"}
{"concept_id": "C3824574", "aliases": [], "types": ["T044"], "canonical_name": "butanol dehydrogenase activity", "definition": "Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+. [GOC:mengo_curators, PMID:1999395, RHEA:33199]"}
{"concept_id": "C3824578", "aliases": [], "types": ["T040"], "canonical_name": "process resulting in tolerance to organic substance"}
{"concept_id": "C3824579", "aliases": [], "types": ["T040"], "canonical_name": "process resulting in tolerance to ketone"}
{"concept_id": "C3824583", "aliases": [], "types": ["T040"], "canonical_name": "process resulting in tolerance to alkane"}
{"concept_id": "C3824584", "aliases": ["Kir2 inward rectifier potassium channel complex location"], "types": ["T026"], "canonical_name": "Kir2 inward rectifier potassium channel complex", "definition": "A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells. [GOC:bhm, PMID:16834334]"}
{"concept_id": "C3824585", "aliases": ["Kir2.1 complex location"], "types": ["T026"], "canonical_name": "Kir2.1 complex"}
{"concept_id": "C3824586", "aliases": ["os penis development", "penile bone development", "penis bone development"], "types": ["T040"], "canonical_name": "baculum development", "definition": "The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure. [GOC:sl, PMID:21471296]"}
{"concept_id": "C3824588", "aliases": [], "types": ["T024"], "canonical_name": "organomineral extracellular matrix", "definition": "An extracellular matrix consisting of a densely packed organomineral assembly in which the mineral phase represents the majority of the material by weight. [GOC:jh2, PMID:15994301]"}
{"concept_id": "C3824589", "aliases": ["USF complex location", "USF complex", "upstream stimulatory factor complex location"], "types": ["T026"], "canonical_name": "upstream stimulatory factor complex", "definition": "A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters. [GOC:bhm, PMID:8576131]"}
{"concept_id": "C3824590", "aliases": [], "types": ["T026"], "canonical_name": "USF1 homodimer"}
{"concept_id": "C3824591", "aliases": [], "types": ["T026"], "canonical_name": "USF1-USF2 heterodimer"}
{"concept_id": "C3824592", "aliases": [], "types": ["T026"], "canonical_name": "USF2 homodimer"}
{"concept_id": "C3824593", "aliases": ["lipid transport across blood brain barrier"], "types": ["T043"], "canonical_name": "lipid transport across blood-brain barrier", "definition": "The directed movement of lipid molecules passing through the blood-brain barrier. [GOC:sjp, PMID:24345162]"}
{"concept_id": "C3824594", "aliases": ["K48-specific deubiquitinase activity", "K48-specific deubiquitinating activity"], "types": ["T044"], "canonical_name": "Lys48-specific deubiquitinase activity", "definition": "Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. [GOC:bf, GOC:PARL, PMID:22970133]"}
{"concept_id": "C3824595", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis"}
{"concept_id": "C3824596", "aliases": [], "types": ["T045"], "canonical_name": "regulation of termination of RNA polymerase II transcription, polyadenylation-coupled"}
{"concept_id": "C3824597", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of termination of RNA polymerase II transcription, polyadenylation-coupled"}
{"concept_id": "C3824598", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of termination of RNA polymerase II transcription, polyadenylation-coupled"}
{"concept_id": "C3824599", "aliases": [], "types": ["T044"], "canonical_name": "ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity", "definition": "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP. [GOC:curators]"}
{"concept_id": "C3824600", "aliases": [], "types": ["T043"], "canonical_name": "cell cycle G2/M phase transition", "definition": "The cell cycle process by which a cell in G2 phase commits to M phase. [GOC:jl, GOC:mtg_cell_cycle]"}
{"concept_id": "C3824601", "aliases": [], "types": ["T044"], "canonical_name": "auxin-regulated transcription"}
{"concept_id": "C3824602", "aliases": [], "types": ["T043"], "canonical_name": "ceramide 1-phosphate transport", "definition": "The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie, PMID:23863933]"}
{"concept_id": "C3824603", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fusion of autophagosome with lysosome"}
{"concept_id": "C3824604", "aliases": ["cranial ganglia morphogenesis"], "types": ["T042"], "canonical_name": "cranial ganglion morphogenesis", "definition": "The process in which the anatomical structure of a cranial ganglion is generated and organized. [GOC:dph]"}
{"concept_id": "C3824605", "aliases": [], "types": ["T043"], "canonical_name": "regulation of flame-shaped neurofibrillary tangle formation"}
{"concept_id": "C3824606", "aliases": [], "types": ["T043"], "canonical_name": "vacuole fusion", "definition": "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. [GOC:pr, GOC:vw, Wikipedia:Vacuole]"}
{"concept_id": "C3824607", "aliases": [], "types": ["T044"], "canonical_name": "exoxylanase activity", "definition": "A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains. [GOC:jh2, ISBN:81-7736-269-0, PMID:16535010]"}
{"concept_id": "C3824608", "aliases": ["de novo centriole assembly"], "types": ["T043"], "canonical_name": "de novo centriole assembly", "definition": "Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects. [GOC:cilia, PMID:25047614, PMID:25291643]"}
{"concept_id": "C3824609", "aliases": [], "types": ["T040"], "canonical_name": "cellular response to virus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:dos]"}
{"concept_id": "C3824611", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA replication origin binding", "definition": "Any process that modulates the frequency, rate or extent of DNA replication origin binding. [GO_REF:0000059, GOC:TermGenie, PMID:11850415]"}
{"concept_id": "C3824612", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cdk5/p20"}
{"concept_id": "C3824613", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of tau-protein kinase I activity"}
{"concept_id": "C3824614", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of STK31"}
{"concept_id": "C3850088", "aliases": ["neutrophil extracellular trap"], "types": ["T026"], "definition": "A network of extracellular fibrillar structures containing granule proteins, chromatin fibers and DNA that are released by neutrophils as part of the host defense response. Extracellular release of antimicrobial proteins such as neutrophil elastase, cathepsin G and histones can bind, disarm, and kill microbes independent of phagocytosis and the fibrillar nature of these structures may target these effects locally by preventing diffusion of these proteins outside the target site.", "canonical_name": "NET"}
{"concept_id": "C3853555", "aliases": [], "types": ["T026"], "canonical_name": "IgG2a"}
{"concept_id": "C3853556", "aliases": [], "types": ["T026"], "canonical_name": "IgG2b"}
{"concept_id": "C3853734", "aliases": ["virus process"], "types": ["T038"], "canonical_name": "viral process", "definition": "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. [GOC:bf, GOC:jl, GOC:mah]"}
{"concept_id": "C3887589", "aliases": ["Embden-Meyerhof-Parnas pathway"], "types": ["T044"], "definition": "An old term for glycolysis. Often it is used to describe anaerobic glucose catabolism that includes the further conversion of PYRUVIC ACID to LACTIC ACID or ETHANOL.", "canonical_name": "Embden-Meyerhof pathway"}
{"concept_id": "C3887595", "aliases": ["autophagosome"], "types": ["T026"], "definition": "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. [GOC:autophagy, ISBN:0198547684, PMID:11099404]", "canonical_name": "autophagic vacuole"}
{"concept_id": "C3887856", "aliases": [], "types": ["T044"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. [GOC:jl]", "canonical_name": "response to unfolded protein"}
{"concept_id": "C3887885", "aliases": ["aromatic amino acid decarboxylase activity", "aromatic-L-amino-acid carboxy-lyase activity", "aromatic-L-amino-acid decarboxylase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. [EC:4.1.1.28]", "canonical_name": "aromatic L-amino acid decarboxylase activity"}
{"concept_id": "C3887886", "aliases": ["L-phenylalanine carboxy-lyase activity", "L-phenylalanine carboxy-lyase (phenylethylamine-forming)", "L-phenylalanine decarboxylase activity"], "types": ["T044"], "canonical_name": "phenylalanine decarboxylase activity", "definition": "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2. [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN]"}
{"concept_id": "C3888039", "aliases": ["cellular response to interleukin-21"], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus. [GOC:BHF, GOC:mah]", "canonical_name": "cellular response to IL-21"}
{"concept_id": "C3888045", "aliases": ["Polycomb Group protein complex location", "Polycomb Group protein complex", "PcG protein complex location"], "types": ["T026"], "definition": "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. [PMID:9372908]", "canonical_name": "PcG protein complex"}
{"concept_id": "C3888047", "aliases": ["rapamycin and nutrient-insensitive TOR complex location", "TORC2 complex", "mTORC2", "TORC2 complex location", "TORC 2 complex location", "rapamycin and nutrient-insensitive TOR complex", "TORC2", "TORC 2 complex", "TOR complex location 2"], "types": ["T026"], "definition": "A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p. [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]", "canonical_name": "TOR complex 2"}
{"concept_id": "C3888074", "aliases": ["ubiquitin-like protein transferase activity", "E3", "small conjugating protein transferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]", "canonical_name": "E2"}
{"concept_id": "C3888075", "aliases": [], "types": ["T044"], "canonical_name": "ciliary neurotrophic factor"}
{"concept_id": "C3888108", "aliases": ["uptake"], "types": ["T043"], "definition": "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. [GOC:dos]", "canonical_name": "import into cell"}
{"concept_id": "C3888151", "aliases": ["E3", "ubiquitin-protein transferase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. [GOC:BioGRID, GOC:jh2, PMID:9635407]", "canonical_name": "E2"}
{"concept_id": "C3888281", "aliases": ["response to IL-21"], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus. [GOC:BHF, GOC:mah]", "canonical_name": "response to interleukin-21"}
{"concept_id": "C3888349", "aliases": ["transcription factor AP-1 complex", "AP-1 complex location", "AP1 complex", "transcription factor AP1 complex", "Activating protein 1 complex location", "AP-1 complex", "AP1 complex location", "transcription factor AP-1 complex location", "transcription factor AP1 complex location"], "types": ["T026"], "definition": "A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes. [GOC:bf, GOC:BHF, GOC:rl, PMID:20060892, PMID:9069263, Wikipedia:AP-1_transcription_factor]", "canonical_name": "Activating protein 1 complex"}
{"concept_id": "C3889565", "aliases": ["UFM1 conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y -> Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C3889566", "aliases": ["SUMO conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C3889567", "aliases": ["NEDD8 conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C3889568", "aliases": ["URM1 conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y -> Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C3889569", "aliases": ["ISG15 conjugating enzyme activity"], "types": ["T044"], "definition": "Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y -> Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "canonical_name": "E2"}
{"concept_id": "C3889573", "aliases": ["peptidase inhibitor complex location"], "types": ["T026"], "definition": "A protein complex which is capable of peptidase inhibitor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20860624]", "canonical_name": "peptidase inhibitor complex"}
{"concept_id": "C3889733", "aliases": ["positive regulation of cyclin-dependent protein kinase activity"], "types": ["T043"], "definition": "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177]", "canonical_name": "positive regulation of CDK activity"}
{"concept_id": "C3889819", "aliases": ["RRP", "synaptic vesicle, readily releasable pool"], "types": ["T026"], "definition": "A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton. [GOC:pad, PMID:22745285]", "canonical_name": "readily releasable pool of synaptic vesicles"}
{"concept_id": "C3889828", "aliases": [], "types": ["T044"], "canonical_name": "5-hydroxytryptophan decarboxylase activity"}
{"concept_id": "C3889829", "aliases": [], "types": ["T044"], "canonical_name": "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)"}
{"concept_id": "C3890026", "aliases": [], "types": ["T044"], "definition": "Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. [GOC:tb]", "canonical_name": "alpha-glucosidase activity"}
{"concept_id": "C3890028", "aliases": ["acinar cell of sebaceous gland differentiation"], "types": ["T042"], "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an acinar cell of sebaceous gland. [GO_REF:0000086, GOC:TermGenie, PMID:17018284, PMID:18334552, PMID:19944183]", "canonical_name": "sebocyte differentiation"}
{"concept_id": "C3890037", "aliases": ["E3"], "types": ["T044"], "definition": "Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S --> X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "canonical_name": "ISG15 ligase activity"}
{"concept_id": "C3890038", "aliases": ["FAT10 ligase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S --> X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "canonical_name": "E3"}
{"concept_id": "C3890039", "aliases": ["E3"], "types": ["T044"], "definition": "Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S --> X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "canonical_name": "URM1 ligase activity"}
{"concept_id": "C3890040", "aliases": ["E3"], "types": ["T044"], "definition": "Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S --> X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "canonical_name": "Pup ligase activity"}
{"concept_id": "C3890041", "aliases": ["UFM1 ligase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S --> X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "canonical_name": "E3"}
{"concept_id": "C3890155", "aliases": ["cellular response to interleukin-7", "response to IL-7", "cellular response to IL-7"], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus. [GOC:BHF, GOC:mah]", "canonical_name": "response to interleukin-7"}
{"concept_id": "C3890158", "aliases": ["response to IL-8"], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus. [GOC:BHF, GOC:mah]", "canonical_name": "response to interleukin-8"}
{"concept_id": "C3890159", "aliases": ["cellular response to IL-8"], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus. [GOC:BHF, GOC:mah]", "canonical_name": "cellular response to interleukin-8"}
{"concept_id": "C3890160", "aliases": ["ryanodine receptor complex location", "RyR"], "types": ["T026"], "definition": "A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom. [GOC:ame, PMID:22822064]", "canonical_name": "ryanodine receptor complex"}
{"concept_id": "C3890161", "aliases": ["signalling cascade involved in septin checkpoint", "signaling pathway involved in septin checkpoint", "signalling pathway involved in septin checkpoint", "signal transduction involved in septin checkpoint", "mitotic morphogenesis checkpoint signaling", "signaling cascade involved in septin checkpoint", "signaling pathway involved in morphogenesis checkpoint", "signalling pathway involved in morphogenesis checkpoint", "signal transduction involved in morphogenesis checkpoint", "signaling cascade involved in morphogenesis checkpoint", "septin checkpoint", "morphogenesis checkpoint"], "types": ["T043"], "definition": "A signaling process that contributes to a mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth. [GOC:jl, GOC:mtg_cell_cycle]", "canonical_name": "signalling cascade involved in morphogenesis checkpoint"}
{"concept_id": "C3890162", "aliases": ["stigma", "eyespot apparatus"], "types": ["T026"], "definition": "A small pigmented organelle used in single-celled organisms to detect light. [Wikipedia:Eyespot_apparatus]", "canonical_name": "eyespot"}
{"concept_id": "C3890163", "aliases": ["tafi"], "types": ["T026"], "canonical_name": "thin aggregative fimbrae"}
{"concept_id": "C3890170", "aliases": ["androst-4-ene-3,17-dione synthesis", "androst-4-ene-3,17-dione anabolism", "androst-4-ene-3,17-dione biosynthesis", "androst-4-ene-3,17-dione formation", "androstenedione biosynthetic process"], "types": ["T044"], "definition": "The chemical reactions and pathways resulting in the formation of androst-4-ene-3,17-dione. [GO_REF:0000068, GOC:mr, GOC:TermGenie, PMID:2028480, PMID:4149619]", "canonical_name": "androst-4-ene-3,17-dione biosynthetic process"}
{"concept_id": "C3890171", "aliases": ["apex"], "types": ["T026"], "definition": "The anterior most point of a dinoflagellate epicone. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]", "canonical_name": "dinoflagellate apex"}
{"concept_id": "C3890172", "aliases": ["SUMO ligase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "canonical_name": "E3"}
{"concept_id": "C3890173", "aliases": ["NEDD8 ligase activity"], "types": ["T044"], "definition": "Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "canonical_name": "E3"}
{"concept_id": "C3890357", "aliases": ["archaeosine synthase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA. [PMID:20129918, RHEA:54084]", "canonical_name": "ArcS"}
{"concept_id": "C3890362", "aliases": ["chaperone-assisted selective autophagy", "CASA", "CMA"], "types": ["T043"], "definition": "The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded. [GOC:pad, GOC:PARL, PMID:22743996, PMID:23434281]", "canonical_name": "chaperone-mediated autophagy"}
{"concept_id": "C3890365", "aliases": ["dendritic lamellar body"], "types": ["T026"], "definition": "A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions. [PMID:7869120]", "canonical_name": "DLB"}
{"concept_id": "C3890367", "aliases": ["enterochelin binding"], "types": ["T044"], "definition": "Binding to enterobactin. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:21951132]", "canonical_name": "enterobactin binding"}
{"concept_id": "C3890558", "aliases": ["INAC", "INA complex"], "types": ["T026"], "definition": "A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p. [GOC:rn, PMID:24942160]", "canonical_name": "INA complex location"}
{"concept_id": "C3890559", "aliases": ["phosphatase and tensin homolog deleted on chromosome ten homodimer", "PTEN phosphatase complex location", "PTEN phosphatase complex", "phosphatase and tensin homolog"], "types": ["T026"], "definition": "A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function. [GOC:bhm, PMID:24766807]", "canonical_name": "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer"}
{"concept_id": "C3891816", "aliases": ["cingulum"], "types": ["T026"], "definition": "A cell surface furrow that wraps around a dinoflagellate cell; the transverse flagellum lies in it. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]", "canonical_name": "dinoflagellate cingulum"}
{"concept_id": "C3892989", "aliases": [], "types": ["T043"], "definition": "The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation. [GOC:hjd]", "canonical_name": "erythrocyte enucleation"}
{"concept_id": "C3893233", "aliases": ["protein phosphatase 2 complex location"], "types": ["T026"], "canonical_name": "protein phosphatase 2 complex"}
{"concept_id": "C3893234", "aliases": ["TERT-TERC complex location"], "types": ["T026"], "canonical_name": "TERT-TERC complex"}
{"concept_id": "C3893235", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cell cycle G1 arrest in response to pheromone", "definition": "The cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae. [GOC:clt, GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C3893236", "aliases": [], "types": ["T043"], "canonical_name": "response to acid chemical", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. [GOC:go_curators, GOC:rn]"}
{"concept_id": "C3893237", "aliases": [], "types": ["T043"], "canonical_name": "response to acid anion"}
{"concept_id": "C3893238", "aliases": [], "types": ["T043"], "canonical_name": "response to oxoanion"}
{"concept_id": "C3893239", "aliases": ["cytoplasmic translation initiation complex assembly"], "types": ["T045"], "canonical_name": "formation of cytoplasmic translation initiation complex", "definition": "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. [GOC:hjd]"}
{"concept_id": "C3893240", "aliases": [], "types": ["T044"], "canonical_name": "glutamine:preQ0-tRNA amidinotransferase"}
{"concept_id": "C3893241", "aliases": ["threonylcarbamoyladenosine formation", "threonylcarbamoyladenosine biosynthetic process", "threonylcarbamoyladenosine biosynthesis", "t6A biosynthetic process", "t6A biosynthesis", "t6A tRNA modification", "threonylcarbamoyladenosine anabolism", "threonylcarbamoyladenosine synthesis"], "types": ["T045"], "canonical_name": "tRNA threonylcarbamoyladenosine modification", "definition": "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). [GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]"}
{"concept_id": "C3893242", "aliases": [], "types": ["T044"], "canonical_name": "hydroxytryptophan decarboxylase activity"}
{"concept_id": "C3893244", "aliases": [], "types": ["T044"], "canonical_name": "tryptophan decarboxylase activity"}
{"concept_id": "C3893246", "aliases": [], "types": ["T026"], "canonical_name": "subcellular entity"}
{"concept_id": "C3893247", "aliases": [], "types": ["T026"], "canonical_name": "initial autophagic vacuole"}
{"concept_id": "C3893248", "aliases": [], "types": ["T026"], "canonical_name": "vesicular component"}
{"concept_id": "C3893249", "aliases": [], "types": ["T026"], "canonical_name": "cis face"}
{"concept_id": "C3893250", "aliases": [], "types": ["T026"], "canonical_name": "trans face"}
{"concept_id": "C3893251", "aliases": [], "types": ["T030"], "canonical_name": "intercellular gap junction channel"}
{"concept_id": "C3893252", "aliases": [], "types": ["T044"], "canonical_name": "ectoderm shedding"}
{"concept_id": "C3893253", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity iron ion transmembrane transport"}
{"concept_id": "C3893254", "aliases": [], "types": ["T043"], "canonical_name": "protein catabolic process in the vacuole", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. [GOC:mah, GOC:vw]"}
{"concept_id": "C3893255", "aliases": [], "types": ["T045"], "canonical_name": "translation factor activity, nucleic acid binding"}
{"concept_id": "C3893256", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 2 regulator activity"}
{"concept_id": "C3893257", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 2, intrinsic regulator activity"}
{"concept_id": "C3893258", "aliases": [], "types": ["T044"], "canonical_name": "demethoxy-ubiquinone hydroxylase"}
{"concept_id": "C3893259", "aliases": [], "types": ["T044"], "canonical_name": "demethoxyubiquinone monooxygenase"}
{"concept_id": "C3893260", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell separation following cytokinesis"}
{"concept_id": "C3893261", "aliases": ["low affinity sodium:dicarboxylate symporter activity"], "types": ["T044"], "canonical_name": "low-affinity sodium:dicarboxylate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [TC:2.A.47.1.1]"}
{"concept_id": "C3893262", "aliases": ["high affinity sodium:dicarboxylate symporter activity"], "types": ["T044"], "canonical_name": "high-affinity sodium:dicarboxylate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [TC:2.A.47.1.4]"}
{"concept_id": "C3893263", "aliases": ["L-malic acid:proton symporter activity", "L-malic acid permease"], "types": ["T044"], "canonical_name": "malate permease"}
{"concept_id": "C3893264", "aliases": [], "types": ["T044"], "canonical_name": "neutral, basic amino acid:sodium:chloride symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in). [TC:2.A.22.2.3]"}
{"concept_id": "C3893265", "aliases": ["nuclear transcription factor Y complex", "NF-Y transcription factor complex location", "nuclear transcription factor Y complex location"], "types": ["T026"], "canonical_name": "NF-Y transcription factor complex"}
{"concept_id": "C3893266", "aliases": [], "types": ["T044"], "canonical_name": "alcoholic fermentation"}
{"concept_id": "C3893267", "aliases": [], "types": ["T044"], "canonical_name": "Atg12 transferase activity", "definition": "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages. [GOC:mah, PMID:12826404]"}
{"concept_id": "C3893268", "aliases": [], "types": ["T044"], "canonical_name": "Atg12 activating enzyme activity", "definition": "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:mah]"}
{"concept_id": "C3893269", "aliases": ["Atg8-specific protease activity"], "types": ["T044"], "canonical_name": "Atg8-specific peptidase activity", "definition": "A thiol-dependent isopeptidase activity that cleaves APG8 from a target protein to which it is conjugated. [GOC:mah, PMID:28901328]"}
{"concept_id": "C3893270", "aliases": [], "types": ["T044"], "canonical_name": "NEDD8 transferase activity", "definition": "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. [GOC:mah]"}
{"concept_id": "C3893271", "aliases": [], "types": ["T044"], "canonical_name": "SUMO transferase activity", "definition": "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. [GOC:rn, PMID:11031248, PMID:11265250]"}
{"concept_id": "C3893272", "aliases": ["fibrous organelle", "trans-epithelial attachment"], "types": ["T026"], "canonical_name": "epidermal attachment structure"}
{"concept_id": "C3893273", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 3 binding"}
{"concept_id": "C3893276", "aliases": [], "types": ["T044"], "canonical_name": "enkephalin receptor binding"}
{"concept_id": "C3893277", "aliases": [], "types": ["T044"], "canonical_name": "dynorphin receptor binding"}
{"concept_id": "C3893278", "aliases": [], "types": ["T044"], "canonical_name": "morphine receptor binding"}
{"concept_id": "C3893279", "aliases": [], "types": ["T026"], "canonical_name": "Golgi lamellae"}
{"concept_id": "C3893280", "aliases": ["regulation of protein phosphatase 3 activity"], "types": ["T044"], "canonical_name": "regulation of protein phosphatase 3 activity"}
{"concept_id": "C3893283", "aliases": [], "types": ["T030"], "canonical_name": "node of Ranvier axon"}
{"concept_id": "C3893284", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein phosphatase type 2 activity"}
{"concept_id": "C3893285", "aliases": ["downregulation of protein phosphatase 2 activity"], "types": ["T044"], "canonical_name": "down regulation of protein phosphatase 2 activity"}
{"concept_id": "C3893288", "aliases": ["upregulation of protein phosphatase 2 activity", "up-regulation of protein phosphatase 2 activity"], "types": ["T044"], "canonical_name": "up regulation of protein phosphatase 2 activity"}
{"concept_id": "C3893289", "aliases": ["Ric1-Rgp1 guanyl-nucleotide exchange factor complex location"], "types": ["T026"], "canonical_name": "Ric1-Rgp1 guanyl-nucleotide exchange factor complex", "definition": "A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi. [GOC:jh, GOC:mah, PMID:10990452]"}
{"concept_id": "C3893290", "aliases": ["autophagy-specific phosphatidylinositol 3-kinase (PtdIns3K) complex location", "autophagy-specific phosphatidylinositol 3-kinase (PtdIns3K) complex", "phosphatidylinositol 3-kinase complex location, class III, type I"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex, class III, type I", "definition": "A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p. [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]"}
{"concept_id": "C3893291", "aliases": ["phosphatidylinositol 3-kinase complex location, class III, type II"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex, class III, type II", "definition": "A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p. [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]"}
{"concept_id": "C3893293", "aliases": ["mitochondrial calcium uptake", "calcium ion transmembrane import into mitochondrion"], "types": ["T043"], "canonical_name": "calcium import into the mitochondrion", "definition": "A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix. [GOC:vw]"}
{"concept_id": "C3893294", "aliases": [], "types": ["T044"], "canonical_name": "BLOC-2 complex binding", "definition": "Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. [GOC:bf, GOC:PARL, PMID:22511774]"}
{"concept_id": "C3893295", "aliases": ["TRAIL-activated extrinsic apoptotic signaling pathway", "TRAIL-induced apoptotic signaling pathway", "tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "TRAIL-activated apoptotic signaling pathway", "definition": "An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface. [GOC:bf, GOC:PARL, PMID:21785459]"}
{"concept_id": "C3893296", "aliases": ["tumor necrosis factor-related apoptosis-inducing ligand receptor"], "types": ["T044"], "canonical_name": "TRAIL receptor activity", "definition": "Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893297", "aliases": [], "types": ["T026"], "definition": "A ribonucleoprotein granule located in the cytoplasm. [GOC:bf, GOC:PARL, PMID:15121898]", "canonical_name": "cytoplasmic ribonucleoprotein granule"}
{"concept_id": "C3893298", "aliases": [], "types": ["T026"], "canonical_name": "Staufen granule"}
{"concept_id": "C3893299", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle recycling", "definition": "The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane. [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]"}
{"concept_id": "C3893300", "aliases": ["kiss-and-stay synaptic vesicle recycling"], "types": ["T043"], "canonical_name": "kiss-and-run synaptic vesicle recycling"}
{"concept_id": "C3893301", "aliases": ["recycling endosome localization within postsynapse"], "types": ["T043"], "canonical_name": "synaptic vesicle recycling via endosome", "definition": "Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate. [GOC:aruk, GOC:bc, GOC:bf, GOC:dos, GOC:pad, GOC:PARL, PMID:15217342]"}
{"concept_id": "C3893302", "aliases": [], "types": ["T044"], "canonical_name": "5-hydroxy-L-tryptophan decarboxylase activity", "definition": "Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin. [GOC:bf, GOC:PARL, RHEA:18533]"}
{"concept_id": "C3893303", "aliases": [], "types": ["T044"], "canonical_name": "L-tryptophan decarboxylase activity", "definition": "Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine. [GOC:bf, GOC:PARL, RHEA:30339]"}
{"concept_id": "C3893304", "aliases": ["tyrosine hydroxylase activator activity", "TH activator activity"], "types": ["T044"], "canonical_name": "tyrosine 3-monooxygenase activator activity", "definition": "Interacts with and increases tyrosine 3-monooxygenase (tyrosine hydroxylase) activity. [GOC:bf, GOC:PARL, PMID:19703902]"}
{"concept_id": "C3893305", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to glyoxal", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893306", "aliases": ["suppression by virus of host protein:protein interaction", "suppression by virus of host protein binding", "suppression by virus of host protein:protein binding", "suppression by virus of host protein interaction"], "types": ["T044"], "canonical_name": "suppression by virus of host protein-protein interaction", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins. [GOC:bf, GOC:PARL, PMID:17297443]"}
{"concept_id": "C3893307", "aliases": [], "types": ["T043"], "canonical_name": "cell death in response to oxidative stress", "definition": "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893308", "aliases": ["cell death in response to H2O2", "hydrogen peroxide-mediated cell death"], "types": ["T043"], "canonical_name": "cell death in response to hydrogen peroxide", "definition": "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2). [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893309", "aliases": ["oxidative stress-induced neuron death", "neuronal cell death in response to oxidative stress"], "types": ["T043"], "canonical_name": "neuron death in response to oxidative stress", "definition": "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893310", "aliases": ["neuron death in response to H2O2", "neuronal cell death in response to hydrogen peroxide", "hydrogen peroxide-induced neuron death"], "types": ["T043"], "canonical_name": "neuron death in response to hydrogen peroxide", "definition": "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2). [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893311", "aliases": [], "types": ["T026"], "canonical_name": "somatodendritic compartment", "definition": "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. [GOC:pad, GOC:PARL]"}
{"concept_id": "C3893312", "aliases": ["DDC activator activity"], "types": ["T044"], "canonical_name": "L-dopa decarboxylase activator activity", "definition": "Interacts with and increases L-dopa decarboxylase activity. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893313", "aliases": [], "types": ["T044"], "canonical_name": "peroxidase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of peroxidase. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893314", "aliases": [], "types": ["T043"], "canonical_name": "neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. [GOC:bf, GOC:PARL, PMID:23858059]"}
{"concept_id": "C3893315", "aliases": ["oxidative stress-induced neuronal apoptosis", "oxidative stress-induced neuron apoptosis"], "types": ["T043"], "canonical_name": "neuron apoptosis in response to oxidative stress"}
{"concept_id": "C3893316", "aliases": ["H2O2-induced intrinsic apoptotic signaling pathway", "hydrogen peroxide-induced intrinsic apoptotic signaling pathway", "intrinsic apoptotic signaling pathway in response to H2O2"], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2). [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893317", "aliases": [], "types": ["T043"], "canonical_name": "hydrogen peroxide-induced apoptosis"}
{"concept_id": "C3893318", "aliases": ["H2O2-induced neuron intrinsic apoptotic signaling pathway", "neuron intrinsic apoptotic signaling pathway in response to H2O2"], "types": ["T043"], "canonical_name": "neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893319", "aliases": [], "types": ["T043"], "canonical_name": "hydrogen peroxide-induced neuron apoptosis"}
{"concept_id": "C3893320", "aliases": ["neuron apoptosis in response to hydrogen peroxide"], "types": ["T043"], "canonical_name": "hydrogen peroxide-induced neuronal apoptosis"}
{"concept_id": "C3893321", "aliases": ["endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway", "ER stress-induced neuron intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:bf, GOC:PARL, PMID:21113145]"}
{"concept_id": "C3893322", "aliases": ["endoplasmic reticulum stress-induced neuron apoptosis"], "types": ["T043"], "canonical_name": "ER stress-induced neuron apoptosis"}
{"concept_id": "C3893323", "aliases": ["trunk NCC migration"], "types": ["T043"], "canonical_name": "trunk neural crest cell migration", "definition": "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo. [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]"}
{"concept_id": "C3893324", "aliases": ["dorsolateral trunk NCC migration"], "types": ["T043"], "canonical_name": "dorsolateral trunk neural crest cell migration", "definition": "The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells. [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]"}
{"concept_id": "C3893325", "aliases": ["ventral trunk NCC migration", "trunk NCC migration through anterior sclerotome", "trunk NCC migration within somite"], "types": ["T043"], "canonical_name": "ventral trunk neural crest cell migration", "definition": "The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta. [GOC:bf, GOC:mat, GOC:PARL, PMID:16319111, PMID:19386662]"}
{"concept_id": "C3893326", "aliases": ["CHOP-C/EBP heterodimer", "GADD153-C/EBP complex", "CHOP-C/EBP complex location", "CHOP-C/EBP dimer", "GADD153-C/EBP complex location"], "types": ["T026"], "canonical_name": "CHOP-C/EBP complex", "definition": "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors. [GOC:bf, GOC:PARL, PMID:1547942]"}
{"concept_id": "C3893327", "aliases": ["GADD153-C/EBP-alpha complex location"], "types": ["T026"], "canonical_name": "GADD153-C/EBP-alpha complex"}
{"concept_id": "C3893328", "aliases": ["neuromelanin biosynthesis", "neuromelanin anabolism", "neuromelanin formation", "neuromelanin synthesis"], "types": ["T044"], "canonical_name": "neuromelanin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers. [GOC:bf, GOC:PARL, Wiki:Neuromelanin]"}
{"concept_id": "C3893329", "aliases": ["regulation of translation in response to ER stress"], "types": ["T043"], "canonical_name": "regulation of translation in response to endoplasmic reticulum stress", "definition": "Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress. [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]"}
{"concept_id": "C3893330", "aliases": ["regulation of translation initiation in response to ER stress"], "types": ["T043"], "canonical_name": "regulation of translation initiation in response to endoplasmic reticulum stress", "definition": "Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress. [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]"}
{"concept_id": "C3893331", "aliases": ["eiF2alpha phosphorylation in response to ER stress", "regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "eiF2alpha phosphorylation in response to endoplasmic reticulum stress", "definition": "The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress. [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]"}
{"concept_id": "C3893332", "aliases": ["positive regulation of translation in response to ER stress"], "types": ["T043"], "canonical_name": "positive regulation of translation in response to endoplasmic reticulum stress", "definition": "Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893333", "aliases": ["positive regulation of translation initiation in response to ER stress"], "types": ["T043"], "canonical_name": "positive regulation of translation initiation in response to endoplasmic reticulum stress", "definition": "Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893334", "aliases": ["negative regulation of translation initiation in response to ER stress"], "types": ["T045"], "canonical_name": "negative regulation of translation initiation in response to endoplasmic reticulum stress", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893335", "aliases": [], "types": ["T044"], "canonical_name": "regulation of translational initiation by eIF2 alpha dephosphorylation", "definition": "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha. [GOC:bf, GOC:PARL]"}
{"concept_id": "C3893336", "aliases": ["eIF2alpha dephosphorylation in response to ER stress", "regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress"], "types": ["T043"], "canonical_name": "eIF2alpha dephosphorylation in response to endoplasmic reticulum stress", "definition": "The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress. [GOC:bf, GOC:PARL, PMID:16835242]"}
{"concept_id": "C3893337", "aliases": ["UPR signaling by IRE1 stress sensor", "IRE1 branch of UPR", "endoplasmic reticulum unfolded protein response; IRE1 signaling"], "types": ["T044"], "canonical_name": "IRE1-mediated unfolded protein response", "definition": "The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. [GOC:bf, GOC:PARL, PMID:22013210]"}
{"concept_id": "C3893338", "aliases": [], "types": ["T044"], "canonical_name": "inositol-requiring transmembrane kinase/endonuclease signal transduction"}
{"concept_id": "C3893339", "aliases": [], "types": ["T044"], "canonical_name": "IRE1 signal transduction pathway"}
{"concept_id": "C3893340", "aliases": [], "types": ["T044"], "canonical_name": "IRE1 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3893341", "aliases": [], "types": ["T044"], "canonical_name": "IRE1alpha unfolded protein response"}
{"concept_id": "C3893342", "aliases": [], "types": ["T044"], "canonical_name": "IRE1p unfolded protein response"}
{"concept_id": "C3893343", "aliases": ["PERK branch of UPR", "PKR-like ER kinase signal transduction", "UPR signaling by PERK stress sensor", "endoplasmic reticulum unfolded protein response; PERK signaling"], "types": ["T044"], "canonical_name": "PERK-mediated unfolded protein response", "definition": "The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. [GOC:bf, GOC:PARL, PMID:22013210, PMID:27629041]"}
{"concept_id": "C3893344", "aliases": [], "types": ["T044"], "canonical_name": "PERK signal transduction pathway"}
{"concept_id": "C3893345", "aliases": [], "types": ["T044"], "canonical_name": "PERK signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3893346", "aliases": ["endoplasmic reticulum unfolded protein response; ATF6 signaling", "UPR signaling by ATF6 stress sensor", "activating transcription factor 6 signaling in unfolded protein response", "ATF6 branch of UPR"], "types": ["T044"], "canonical_name": "ATF6-mediated unfolded protein response", "definition": "The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity. [GOC:bf, GOC:PARL, PMID:22013210]"}
{"concept_id": "C3893347", "aliases": [], "types": ["T044"], "canonical_name": "ATF6 signal transduction pathway"}
{"concept_id": "C3893348", "aliases": [], "types": ["T044"], "canonical_name": "ATF6 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3893349", "aliases": [], "types": ["T044"], "canonical_name": "ATF6-alpha UPR branch"}
{"concept_id": "C3893350", "aliases": [], "types": ["T044"], "canonical_name": "ISG15 transferase activity", "definition": "Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. [GOC:mah, PMID:12826404]"}
{"concept_id": "C3893351", "aliases": [], "types": ["T043"], "canonical_name": "myelinogenesis"}
{"concept_id": "C3893352", "aliases": [], "types": ["T043"], "canonical_name": "FtsZ-dependent cytokinesis", "definition": "A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells. [GOC:mah, ISBN:0815108893, PMID:12626683]"}
{"concept_id": "C3893353", "aliases": ["CENP-S-T-W-X", "CenH3 containing nucleosome", "CNP-T-W-S-X complex", "CNP-T-W-S-X complex location"], "types": ["T026"], "canonical_name": "CENP-A containing nucleosome", "definition": "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3). [GOC:go_curators, PMID:15175412, PMID:16183641]"}
{"concept_id": "C3893354", "aliases": ["6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex location"], "types": ["T026"], "canonical_name": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex", "definition": "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis. [GOC:jl, GOC:so]"}
{"concept_id": "C3893355", "aliases": ["6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex location"], "types": ["T026"], "canonical_name": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex"}
{"concept_id": "C3893356", "aliases": ["6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex location"], "types": ["T026"], "canonical_name": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex"}
{"concept_id": "C3893357", "aliases": ["6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex location"], "types": ["T026"], "canonical_name": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex"}
{"concept_id": "C3893358", "aliases": [], "types": ["T026"], "canonical_name": "juxta paranode axon"}
{"concept_id": "C3893359", "aliases": [], "types": ["T026"], "canonical_name": "spine head"}
{"concept_id": "C3893361", "aliases": [], "types": ["T038"], "canonical_name": "biological phase", "definition": "A distinct period or stage in a biological process or cycle. [GOC:jl]"}
{"concept_id": "C3893362", "aliases": [], "types": ["T038"], "canonical_name": "hair cycle phase", "definition": "The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. [GOC:jl]"}
{"concept_id": "C3893364", "aliases": [], "types": ["T026"], "canonical_name": "plasma membrane raft", "definition": "A membrane raft that is part of the plasma membrane. [GOC:jl]"}
{"concept_id": "C3893365", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane raft assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft. [GOC:jl]"}
{"concept_id": "C3893366", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane raft distribution", "definition": "The process that establishes the spatial arrangement of membrane rafts within a plasma membrane. [GOC:jl]"}
{"concept_id": "C3893367", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane raft localization", "definition": "Any process in which plasma membrane rafts are transported to, or maintained in, a specific location. [GOC:jl]"}
{"concept_id": "C3893368", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane raft organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts. [GOC:jl]"}
{"concept_id": "C3893369", "aliases": ["plasma membrane polarization"], "types": ["T043"], "canonical_name": "plasma membrane raft polarization", "definition": "The clustering and aggregation of a plasma membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. [GOC:jl]"}
{"concept_id": "C3893370", "aliases": [], "types": ["T043"], "canonical_name": "protein insertion into plasma membrane raft", "definition": "The process in which a protein is incorporated into a plasma membrane raft. [GOC:jl]"}
{"concept_id": "C3893371", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to plasma membrane raft", "definition": "A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft. [GOC:jl]"}
{"concept_id": "C3893372", "aliases": [], "types": ["T043"], "canonical_name": "protein transport into plasma membrane raft", "definition": "The directed movement of a protein into a plasma membrane raft. [GOC:jl]"}
{"concept_id": "C3893373", "aliases": [], "types": ["T043"], "canonical_name": "protein transport out of plasma membrane raft", "definition": "The directed movement of a protein out of a plasma membrane raft. [GOC:jl]"}
{"concept_id": "C3893374", "aliases": ["regulation by virus of host cell division"], "types": ["T043"], "canonical_name": "modulation by virus of host cell division", "definition": "Any process where an infecting virus modulates the frequency, rate or extent of the physical partitioning and separation of its host's cell into daughter cells. [GOC:jl]"}
{"concept_id": "C3893375", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation by virus of host cell division", "definition": "Any process where an infecting virus activates or increases the frequency, rate or extent of its host's cell division. [GOC:jl]"}
{"concept_id": "C3893376", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by virus of host cell division", "definition": "Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division. [GOC:jl]"}
{"concept_id": "C3893377", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of viral exo-alpha-sialidase activity", "definition": "The process in which a host organism effects a change in viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. [GOC:jl]"}
{"concept_id": "C3893378", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of viral catalytic activity", "definition": "The process in which a host organism effects a change in the enzyme activity of a virus with which it is infected. [GOC:jl]"}
{"concept_id": "C3893379", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of viral molecular function", "definition": "A process in which a host organism modulates the frequency, rate or extent of any molecular function being mediated by a virus with which it is infected. [GOC:jl]"}
{"concept_id": "C3893380", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by host of viral exo-alpha-sialidase activity", "definition": "The process in which a host organism decreases viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. [GOC:jl]"}
{"concept_id": "C3893381", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of viral glycoprotein metabolic process", "definition": "A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process. [GOC:jl]"}
{"concept_id": "C3893382", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by host of viral glycoprotein metabolic process", "definition": "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process. [GOC:jl]"}
{"concept_id": "C3893383", "aliases": [], "types": ["T043"], "canonical_name": "lipoprotein localization", "definition": "Any process in which a lipoprotein is transported to, or maintained in, a specific location. [GOC:jl]"}
{"concept_id": "C3893384", "aliases": [], "types": ["T043"], "canonical_name": "lipoprotein localization to membrane", "definition": "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane. [GOC:jl]"}
{"concept_id": "C3893385", "aliases": [], "types": ["T043"], "canonical_name": "lipoprotein localization to outer membrane", "definition": "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. [GOC:jl]"}
{"concept_id": "C3893386", "aliases": ["gamma-glutamyl hercynylcysteine sulfoxide synthase", "gamma-glutamyl hercynylcysteine S-oxide synthase"], "types": ["T044"], "canonical_name": "gamma-glutamyl hercynylcysteine sulfoxide synthase activity", "definition": "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O. [GOC:jl, PMID:24828577, RHEA:42672]"}
{"concept_id": "C3893387", "aliases": [], "types": ["T044"], "canonical_name": "hercynylselenocysteine synthase", "definition": "Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 <=> 2 H2O + 2 hercynylselenocysteine. [GOC:jl, PMID:24828577, RHEA:42680]"}
{"concept_id": "C3893388", "aliases": [], "types": ["T044"], "canonical_name": "macromolecular complex binding"}
{"concept_id": "C3893389", "aliases": [], "types": ["T043"], "canonical_name": "cytokinesis after mitosis checkpoint"}
{"concept_id": "C3893390", "aliases": [], "types": ["T040"], "canonical_name": "nematode male tail tip morphogenesis", "definition": "The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome. [GOC:kmv, PMID:16806150, PMID:18050419, PMID:21408209, PMID:7409314]"}
{"concept_id": "C3893391", "aliases": [], "types": ["T043"], "canonical_name": "microtubule formation"}
{"concept_id": "C3893392", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial envelope permeability"}
{"concept_id": "C3893393", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle trafficking"}
{"concept_id": "C3893394", "aliases": [], "types": ["T026"], "canonical_name": "pre-synaptic active zone component"}
{"concept_id": "C3893395", "aliases": [], "types": ["T040"], "canonical_name": "thermal nociception"}
{"concept_id": "C3893396", "aliases": [], "types": ["T039"], "canonical_name": "mechanical nociception"}
{"concept_id": "C3893397", "aliases": [], "types": ["T039"], "canonical_name": "chemical nociception"}
{"concept_id": "C3893398", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 2 binding"}
{"concept_id": "C3893399", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glutamate uptake involved in conduction of nerve impulse"}
{"concept_id": "C3893401", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of APC-Cdc20 complex activity"}
{"concept_id": "C3893402", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to acidic pH", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7. [GOC:dph, GOC:go_curators]"}
{"concept_id": "C3893403", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0. [GOC:dph, PMID:11523797, PMID:15299026, PMID:21749328]"}
{"concept_id": "C3893404", "aliases": [], "types": ["T044"], "canonical_name": "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase"}
{"concept_id": "C3893405", "aliases": [], "types": ["T044"], "canonical_name": "OMHMB-methyltransferase"}
{"concept_id": "C3893406", "aliases": [], "types": ["T044"], "canonical_name": "5-demethylubiquinone-10 methyltransferase"}
{"concept_id": "C3893407", "aliases": [], "types": ["T044"], "canonical_name": "5-demethylubiquinone-9 methyltransferase"}
{"concept_id": "C3893408", "aliases": [], "types": ["T044"], "canonical_name": "RNA lariat debranching enzyme activator activity", "definition": "Increases the activity of an enzyme that catalyzes the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide. [GOC:dph, PMID:24919400]"}
{"concept_id": "C3893409", "aliases": [], "types": ["T044"], "canonical_name": "transport-coupled glycolytic process through glucose-6-phosphate", "definition": "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport. [GOC:dph]"}
{"concept_id": "C3893410", "aliases": ["alpha-xylosidase"], "types": ["T044"], "canonical_name": "alpha-D-xyloside xylohydrolase", "definition": "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose. [EC:3.2.1.177]"}
{"concept_id": "C3893411", "aliases": [], "types": ["T038"], "canonical_name": "regulation of protein complex stability", "definition": "Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly. [GOC:dph]"}
{"concept_id": "C3893412", "aliases": [], "types": ["T044"], "canonical_name": "mitotic anaphase-promoting complex activator activity"}
{"concept_id": "C3893413", "aliases": [], "types": ["T044"], "canonical_name": "mitotic anaphase-promoting complex inhibitor activity"}
{"concept_id": "C3893414", "aliases": ["centromeric core region chromatin", "chromatin containing CENP-A"], "types": ["T026"], "canonical_name": "CENP-A containing chromatin", "definition": "The specialized chromatin located in the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment. [GOC:vw, PMID:20206496, PMID:22729156, PMID:24710126]"}
{"concept_id": "C3893415", "aliases": [], "types": ["T026"], "canonical_name": "centromeric core domain chromatin"}
{"concept_id": "C3893416", "aliases": [], "types": ["T043"], "canonical_name": "Cdv-dependent cytokinesis", "definition": "A cytokinesis that involves a set of conserved proteins including the Cdv proteins, and results in the formation of two similarly sized and shaped cells. [GOC:dph, PMID:18987308]"}
{"concept_id": "C3893417", "aliases": [], "types": ["T043"], "canonical_name": "cytoskeleton-dependent cytokinesis", "definition": "A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. [GOC:dph]"}
{"concept_id": "C3893418", "aliases": [], "types": ["T045"], "canonical_name": "CENP-A containing chromatin organization", "definition": "Any process that results in the specification, formation or maintenance of the physical structure of CENP-A containing chromatin. [GOC:dph]"}
{"concept_id": "C3893419", "aliases": [], "types": ["T045"], "canonical_name": "centromeric chromatin organization"}
{"concept_id": "C3893420", "aliases": [], "types": ["T043"], "canonical_name": "chemoattraction of axon", "definition": "The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal. [GOC:dph, GOC:krc]"}
{"concept_id": "C3893421", "aliases": [], "types": ["T043"], "canonical_name": "chemorepulsion of axon", "definition": "The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. [GOC:dph, GOC:krc]"}
{"concept_id": "C3893422", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to CENP-A containing chromatin", "definition": "Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin. [GOC:dph, GOC:vw]"}
{"concept_id": "C3893423", "aliases": [], "types": ["T026"], "canonical_name": "endocytic patch", "definition": "The part of the cell cortex consisting of an aggregation of proteins that will give rise to an endocytic vesicle. [GOC:dph, PMID:22949647]"}
{"concept_id": "C3893424", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization", "definition": "Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter. [GOC:pad, GOC:PARL]"}
{"concept_id": "C3893425", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K9 modification", "definition": "The modification of histone H3 at a lysine in position 9 of the histone. [GOC:vw]"}
{"concept_id": "C3893426", "aliases": [], "types": ["T042"], "canonical_name": "tooth replacement", "definition": "The process whose specific outcome is the replacement of an existing tooth with another tooth. [GOC:dph, PMID:15170864]"}
{"concept_id": "C3893427", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitinated histone binding"}
{"concept_id": "C3893428", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial ribosome assembly", "definition": "The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits. [GOC:dph]"}
{"concept_id": "C3893429", "aliases": ["stimulus-independent neurotransmitter secretion"], "types": ["T043"], "canonical_name": "spontaneous neurotransmitter secretion", "definition": "Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential. [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193]"}
{"concept_id": "C3893430", "aliases": ["stimulus-dependant neurotransmitter secretion"], "types": ["T043"], "canonical_name": "evoked neurotransmitter secretion", "definition": "Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential. [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193]"}
{"concept_id": "C3893431", "aliases": ["Cbp3p-Cbp6 complex location"], "types": ["T026"], "canonical_name": "Cbp3p-Cbp6 complex", "definition": "A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly. [GOC:dph, GOC:rb, PMID:21670217]"}
{"concept_id": "C3893432", "aliases": ["gamma-glutamyltranspeptidase complex location", "glutathionase complex", "glutathionase complex location", "gamma-glutamyltranspeptidase complex", "glutathione hydrolase complex location"], "types": ["T026"], "canonical_name": "glutathione hydrolase complex", "definition": "Enzyme complex that in S. cerevisiae has components Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly. [GOC:dph]"}
{"concept_id": "C3893433", "aliases": ["glutamine amidotransferase II complex location"], "types": ["T026"], "canonical_name": "glutamine amidotransferase II complex"}
{"concept_id": "C3893434", "aliases": [], "types": ["T026"], "canonical_name": "mitotic spindle astral microtubule", "definition": "Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. [GOC:dph]"}
{"concept_id": "C3893435", "aliases": [], "types": ["T045"], "canonical_name": "gap filling involved in double-strand break repair via nonhomologous end joining", "definition": "Repair of the gaps in the DNA helix using a discontinuous template during double-strand break repair via nonhomologous end joining. [GOC:dph]"}
{"concept_id": "C3893436", "aliases": ["rhamnose-binding lectin family protein binding"], "types": ["T044"], "canonical_name": "RBL family protein binding", "definition": "Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose. [PMID:22312473]"}
{"concept_id": "C3893437", "aliases": [], "types": ["T044"], "canonical_name": "importin-alpha family protein binding", "definition": "Binding to a member of the importin-alpha family. [PMID:15350979, PMID:17170104, PMID:23734157]"}
{"concept_id": "C3893438", "aliases": ["KDG aldolase activity", "2-keto-3-deoxygluconate aldolase activity"], "types": ["T044"], "canonical_name": "2-dehydro-3-deoxy-D-gluconate aldolase activity", "definition": "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate <=> pyruvate + D-glyceraldehyde. [EC:4.1.2.51, GOC:dph, PMID:12824170, RHEA:35583]"}
{"concept_id": "C3893439", "aliases": [], "types": ["T044"], "canonical_name": "Entner-Doudoroff pathway", "definition": "A cellular carbohydrate catabolic process that converts a carbohydrate to pyruvate and either glyceraldehyde or glyceraldehyde-3 phosphate by dehydration and aldol cleavage via a gluconate or 6-phosphogluconate intermediate. [GOC:dph, PMID:12921536]"}
{"concept_id": "C3893440", "aliases": [], "types": ["T044"], "canonical_name": "Entner-Doudoroff pathway through gluconate", "definition": "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate. [GOC:dph, PMID:12921536]"}
{"concept_id": "C3893441", "aliases": [], "types": ["T044"], "canonical_name": "Entner-Doudoroff pathway through gluconate to D-glyceraldehyde", "definition": "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde. [GOC:dph, MetaCyc:ENTNER-DOUDOROFF-PWY-II, PMID:12921536]"}
{"concept_id": "C3893442", "aliases": [], "types": ["T044"], "canonical_name": "Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate", "definition": "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate. [GOC:dph, MetaCyc:ENTNER-DOUFDOROFF-PWY-III, PMID:12921536]"}
{"concept_id": "C3893443", "aliases": [], "types": ["T040"], "canonical_name": "seminal vesicle morphogenesis", "definition": "The process in which the anatomical structures of a seminal vesicle are generated and organized. [GOC:dph]"}
{"concept_id": "C3893444", "aliases": ["seminal vesicle branching", "gonecyst branching morphogenesis", "seminal gland branching morphogenesis", "seminal vesicle branching morphogenesis"], "types": ["T040"], "canonical_name": "branching involved in seminal vesicle morphogenesis", "definition": "The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem. [GOC:dph, PMID:16916376]"}
{"concept_id": "C3893445", "aliases": [], "types": ["T044"], "canonical_name": "diphthine methylesterase activity", "definition": "Catalysis of the reaction: diphthine methyl ester + H2O <=> diphthine + H+ + methanol. [GOC:dph, PMID:24739148, RHEA:42656]"}
{"concept_id": "C3893446", "aliases": ["hercynylcysteine S-oxide synthase", "hercynylcysteine sulfoxide synthase"], "types": ["T044"], "canonical_name": "hercynylcysteine sulfoxide synthase activity", "definition": "Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 <=> hercynylcysteine sulfoxide + H2O. [GOC:dph, PMID:24828577, PMID:4276459, RHEA:42704]"}
{"concept_id": "C3893447", "aliases": [], "types": ["T040"], "canonical_name": "detoxification of inorganic compound", "definition": "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds. [GOC:vw]"}
{"concept_id": "C3893448", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic process via Entner-Doudoroff Pathway", "definition": "A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes. [GOC:dph, PMID:9657988]"}
{"concept_id": "C3893449", "aliases": ["autophagy-specific phosphatidylinositol 3-kinase complex location"], "types": ["T026"], "canonical_name": "autophagy-specific phosphatidylinositol 3-kinase complex"}
{"concept_id": "C3893450", "aliases": ["cyclin H-CDK7 complex location"], "types": ["T026"], "canonical_name": "cyclin H-CDK7 complex", "definition": "OBSOLETE. A protein complex consisting of cyclin H and cyclin-dependent kinase 7 (CDK7). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [PMID:9857180]"}
{"concept_id": "C3893451", "aliases": ["Mcs6/Mcs2/Pmh1 complex location"], "types": ["T026"], "canonical_name": "Mcs6/Mcs2/Pmh1 complex"}
{"concept_id": "C3893452", "aliases": [], "types": ["T044"], "canonical_name": "protein targeting to autophagosome"}
{"concept_id": "C3893453", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to acid chemical", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. [GOC:go_curators, GOC:mah, Wikipedia:Acid]"}
{"concept_id": "C3893454", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to acid anion"}
{"concept_id": "C3893455", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to oxoanion"}
{"concept_id": "C3893456", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to alkalinity"}
{"concept_id": "C3893457", "aliases": [], "types": ["T043"], "canonical_name": "plant cell wall assembly"}
{"concept_id": "C3893458", "aliases": [], "types": ["T044"], "canonical_name": "swell-activated chloride channel"}
{"concept_id": "C3893459", "aliases": [], "types": ["T044"], "canonical_name": "Pup transferase activity", "definition": "Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y --> Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages. [GOC:sp]"}
{"concept_id": "C3893460", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 2 activator activity"}
{"concept_id": "C3893461", "aliases": ["protein kinase D signal transduction", "PKD signal transduction"], "types": ["T044"], "canonical_name": "protein kinase D signaling", "definition": "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound. [GOC:BHF, GOC:dos, GOC:mah]"}
{"concept_id": "C3893462", "aliases": [], "types": ["T044"], "canonical_name": "PKD signaling cascade"}
{"concept_id": "C3893463", "aliases": ["protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "protein kinase D signaling cascade"}
{"concept_id": "C3893464", "aliases": ["U2 accessory factor", "U2AF", "U2AF complex location"], "types": ["T026"], "canonical_name": "U2AF complex", "definition": "A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point. [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]"}
{"concept_id": "C3893465", "aliases": [], "types": ["T044"], "canonical_name": "undecaprenyl-phosphate glucose phosphotransferase activity", "definition": "Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol. [EC:2.7.8.31, GOC:dos, GOC:imk]"}
{"concept_id": "C3893466", "aliases": [], "types": ["T043"], "canonical_name": "L-aspartate transmembrane export from vacuole", "definition": "The directed movement of L-aspartate out of the vacuole, across the vacuolar membrane. [PMID:21307582]"}
{"concept_id": "C3893467", "aliases": [], "types": ["T043"], "canonical_name": "L-glutamate transmembrane export from vacuole", "definition": "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane. [PMID:21307582]"}
{"concept_id": "C3893468", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to outer membrane", "definition": "A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane. [GOC:dos, PMID:12823819]"}
{"concept_id": "C3893469", "aliases": [], "types": ["T043"], "canonical_name": "L-ornithine transmembrane export from vacuole", "definition": "The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane. [PMID:21307582]"}
{"concept_id": "C3893470", "aliases": [], "types": ["T043"], "canonical_name": "L-lysine transmembrane export from vacuole", "definition": "The directed movement of L-lysine out of the vacuole, across the vacuolar membrane. [PMID:21307582]"}
{"concept_id": "C3893471", "aliases": [], "types": ["T043"], "canonical_name": "L-histidine transmembrane export from vacuole", "definition": "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane. [PMID:21307582]"}
{"concept_id": "C3893472", "aliases": [], "types": ["T044"], "canonical_name": "L-histidine transmembrane transport", "definition": "The directed movement of L-histidine across a membrane. [PMID:21307582]"}
{"concept_id": "C3893473", "aliases": [], "types": ["T044"], "canonical_name": "endocytic targeting sequence binding", "definition": "Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits. [PMID:8918456]"}
{"concept_id": "C3893475", "aliases": [], "types": ["T043"], "canonical_name": "L-aspartate transmembrane transport", "definition": "The directed movement of L-aspartate across a membrane. [PMID:21307582]"}
{"concept_id": "C3893476", "aliases": ["Cbf1-Met4-Met28 complex location"], "types": ["T026"], "canonical_name": "Cbf1-Met4-Met28 complex", "definition": "A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation. [PMID:8665859, PMID:9171357]"}
{"concept_id": "C3893477", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetyl-D-mannosamine dehydrogenase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+. [EC:1.1.1.336]"}
{"concept_id": "C3893478", "aliases": [], "types": ["T045"], "canonical_name": "tRNA m6t6A37 methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine. [PMID:25063302]"}
{"concept_id": "C3893479", "aliases": ["Pip2-Oaf1 complex location"], "types": ["T026"], "canonical_name": "Pip2-Oaf1 complex", "definition": "A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins. [PMID:8972187, PMID:9288897]"}
{"concept_id": "C3893480", "aliases": [], "types": ["T026"], "canonical_name": "spanning component of membrane", "definition": "The component of a membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane. [GOC:dos]"}
{"concept_id": "C3893481", "aliases": ["amino acid import into cell"], "types": ["T043"], "canonical_name": "amino acid import across plasma membrane", "definition": "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]"}
{"concept_id": "C3893482", "aliases": ["inhibitor of apoptosis binding domain binding", "RHG domain binding", "iap binding domain binding", "reaper hid grim domain binding"], "types": ["T044"], "canonical_name": "RHG protein domain binding", "definition": "Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif). [GOC:dos, GOC:ha]"}
{"concept_id": "C3893483", "aliases": [], "types": ["T044"], "canonical_name": "caspase binding", "definition": "Binding to a caspase family protein. [GOC:dos, GOC:ha]"}
{"concept_id": "C3893484", "aliases": [], "types": ["T044"], "canonical_name": "phosphoenolpyruvate transmembrane transporter activity", "definition": "Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other. [GOC:dos]"}
{"concept_id": "C3893485", "aliases": [], "types": ["T043"], "canonical_name": "phosphoenolpyruvate transmembrane transport", "definition": "The directed movement of phosphoenolpytuvate across a membrane. [GOC:dos]"}
{"concept_id": "C3893486", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in). [PMID:14645248]"}
{"concept_id": "C3893487", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in). [PMID:8626640]"}
{"concept_id": "C3893488", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in). [PMID:8875915]"}
{"concept_id": "C3893489", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-galactitol-phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in). [PMID:8955298]"}
{"concept_id": "C3893490", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in). [PMID:15153772]"}
{"concept_id": "C3893491", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in). [PMID:8246840]"}
{"concept_id": "C3893492", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-glucosamine phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in). [PMID:8246840]"}
{"concept_id": "C3893493", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in). [PMID:15060041]"}
{"concept_id": "C3893494", "aliases": [], "types": ["T044"], "canonical_name": "protein-phosphocysteine-trehalose phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in). [PMID:7608078]"}
{"concept_id": "C3893495", "aliases": [], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in). [PMID:8246840]"}
{"concept_id": "C3893496", "aliases": [], "types": ["T044"], "canonical_name": "protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity", "definition": "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in). [PMID:9864311]"}
{"concept_id": "C3893497", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis involved in DNA replication", "definition": "Synthesis of DNA that is a part of the process of duplicating one or more molecules of DNA. [GOC:vw]"}
{"concept_id": "C3893498", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine autophosphorylation", "definition": "The phosphorylation by a protein of one or more of its own histidine residues, or a histidine residue on an identical protein. [PMID:15947782, PMID:8962061]"}
{"concept_id": "C3893499", "aliases": [], "types": ["T046"], "canonical_name": "inflammatory response to wounding", "definition": "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents. [GOC:add]"}
{"concept_id": "C3893500", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA:L-lysine N6-acetyltransferase", "definition": "Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H(+). [MetaCyc:LYSACET-RXN]"}
{"concept_id": "C3893501", "aliases": [], "types": ["T040"], "canonical_name": "sensory organ morphogenesis", "definition": "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:kmv, ISBN:978-0199210893]"}
{"concept_id": "C3893502", "aliases": [], "types": ["T042"], "canonical_name": "nematode male tail mating organ morphogenesis", "definition": "The process in which the anatomical structures of the nematode male tail mating organ are generated and organized. The male tail is a sensory organ required for mating and, in C. elegans, consists of ray sensilla, an acellular cuticular fan, a sensory hook, and protracting, copulatory spicules. [GOC:kmv, PMID:1782863, PMID:18050419, PMID:7409314]"}
{"concept_id": "C3893503", "aliases": [], "types": ["T040"], "canonical_name": "male anatomical structure morphogenesis", "definition": "The processes by which anatomical structures that are only present in the male organism are generated and organized. [GOC:kmv, GOC:tb]"}
{"concept_id": "C3893504", "aliases": [], "types": ["T044"], "canonical_name": "alpha-1,3-glucosidase activity", "definition": "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose. [GOC:sd, GOC:tb]"}
{"concept_id": "C3893505", "aliases": [], "types": ["T043"], "canonical_name": "sieve element enucleation", "definition": "The process in which nucleated precursor cells lose their nucleus as part of sieve element differentiation. The nuclear contents are released and degraded in the cytoplasm at the same time as other organelles are rearranged and the cytosol is degraded. [GOC:tb, PMID:25081480]"}
{"concept_id": "C3893506", "aliases": [], "types": ["T043"], "canonical_name": "sieve element differentiation", "definition": "The process whereby a relatively unspecialized cell acquires specialized features of a sieve element. [GOC:tb]"}
{"concept_id": "C3893507", "aliases": [], "types": ["T043"], "canonical_name": "surface biofilm formation", "definition": "A process in which planktonically growing microorganisms grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. [GOC:di, GOC:tb]"}
{"concept_id": "C3893508", "aliases": [], "types": ["T043"], "canonical_name": "submerged biofilm formation", "definition": "A process in which planktonically growing microorganisms aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription. [GOC:di, GOC:tb]"}
{"concept_id": "C3893509", "aliases": [], "types": ["T043"], "canonical_name": "solid substrate biofilm formation"}
{"concept_id": "C3893510", "aliases": [], "types": ["T043"], "canonical_name": "single-species surface biofilm formation", "definition": "A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface. [GOC:ml]"}
{"concept_id": "C3893513", "aliases": [], "types": ["T043"], "canonical_name": "single-species submerged biofilm formation", "definition": "A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription. [GOC:di, GOC:tb]"}
{"concept_id": "C3893514", "aliases": [], "types": ["T043"], "canonical_name": "bundle sheath cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a bundle sheath cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:tb, PMID:24517883]"}
{"concept_id": "C3893515", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination. [PMID:22547407]"}
{"concept_id": "C3893516", "aliases": ["cyclic adenosine monophosphate deaminase activity"], "types": ["T044"], "canonical_name": "cAMP deaminase activity", "definition": "Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3. [PMID:24074367, RHEA:22908]"}
{"concept_id": "C3893517", "aliases": [], "types": ["T044"], "canonical_name": "5'-deoxyadenosine deaminase activity", "definition": "Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3. [PMID:23968233, RHEA:42892]"}
{"concept_id": "C3893518", "aliases": [], "types": ["T044"], "canonical_name": "5'-methylthioadenosine deaminase activity", "definition": "Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3. [PMID:23968233, RHEA:25025]"}
{"concept_id": "C3893519", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial mRNA processing", "definition": "Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs. [GOC:tb, PMID:25181358]"}
{"concept_id": "C3893520", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial mRNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of an mRNA molecule that derives from the mitochondrial genome. [GOC:tb, PMID:25181358]"}
{"concept_id": "C3893521", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial mRNA 5'-end processing", "definition": "Any process involved in forming the mature 5' end of an mRNA molecule that derives from the mitochondrial genome. [GOC:tb, PMID:25181358]"}
{"concept_id": "C3893522", "aliases": [], "types": ["T043"], "canonical_name": "DNA clamp unloading", "definition": "The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates. [GOC:rb, PMID:23499004]"}
{"concept_id": "C3893523", "aliases": [], "types": ["T043"], "canonical_name": "PCNA unloading"}
{"concept_id": "C3893524", "aliases": [], "types": ["T026"], "canonical_name": "meiotic spindle pole", "definition": "Either of the ends of a meiotic spindle, a spindle that forms as part of meiosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:ha, PMID:18250200]"}
{"concept_id": "C3893528", "aliases": [], "types": ["T044"], "canonical_name": "APC-fizzy related complex activity"}
{"concept_id": "C3893529", "aliases": [], "types": ["T044"], "canonical_name": "activation of APC-fizzy related complex activity"}
{"concept_id": "C3893530", "aliases": [], "types": ["T045"], "canonical_name": "endoribonuclease activity, cleaving miRNA-paired mRNA", "definition": "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970, PMID:19239888]"}
{"concept_id": "C3893531", "aliases": ["mRNA destabilization-mediated gene silencing by siRNA", "mRNA cleavage involved in gene silencing by siRNA"], "types": ["T045"], "canonical_name": "siRNA-mediated gene silencing by mRNA destabilization", "definition": "An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970]"}
{"concept_id": "C3893532", "aliases": [], "types": ["T040"], "canonical_name": "plant epidermis morphogenesis", "definition": "The process in which the anatomical structures of the plant epidermis are generated and organized. [GOC:tb]"}
{"concept_id": "C3893533", "aliases": [], "types": ["T043"], "canonical_name": "plant epidermal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized features of a plant epidermal cell. [GOC:tb]"}
{"concept_id": "C3893534", "aliases": [], "types": ["T043"], "canonical_name": "plant epidermal cell fate specification", "definition": "The process in which a cell becomes capable of differentiating autonomously into a plant epidermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [GOC:tb]"}
{"concept_id": "C3893535", "aliases": [], "types": ["T045"], "canonical_name": "lagging strand initiation", "definition": "The process in which the synthesis of DNA from a template strand in a net 3' to 5' direction is started. [GOC:mah, GOC:tb]"}
{"concept_id": "C3893537", "aliases": ["CMP-Neu5Gc synthetase activity"], "types": ["T044"], "canonical_name": "N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity", "definition": "Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc. [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411]"}
{"concept_id": "C3893538", "aliases": ["CMP-KDN synthetase activity", "cytidine 5'-monophospho-2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid synthetase activity"], "types": ["T044"], "canonical_name": "keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity", "definition": "Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN. [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411]"}
{"concept_id": "C3893539", "aliases": [], "types": ["T045"], "canonical_name": "CENP-A containing nucleosome binding", "definition": "Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3). [GOC:jp, PMID:21412236]"}
{"concept_id": "C3893540", "aliases": ["presynaptic neurexin clustering"], "types": ["T044"], "canonical_name": "neurexin clustering involved in presynaptic membrane assembly", "definition": "The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals. [GOC:BHF, GOC:sjp, PMID:12796785]"}
{"concept_id": "C3893541", "aliases": [], "types": ["T043"], "canonical_name": "gephyrin clustering involved in postsynaptic density assembly", "definition": "The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses. [GOC:BHF, GOC:sjp, PMID:15620359, PMID:24552784, PMID:25772192]"}
{"concept_id": "C3893542", "aliases": ["postsynaptic neuroligin clustering"], "types": ["T044"], "canonical_name": "neuroligin clustering involved in postsynaptic membrane assembly", "definition": "The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons. [GOC:BHF, GOC:sjp, PMID:12796785]"}
{"concept_id": "C3893543", "aliases": [], "types": ["T043"], "canonical_name": "chromosome attachment to the nuclear envelope", "definition": "The process in which chromatin is anchored to the nuclear envelope. [GOC:vw, PMID:31635174]"}
{"concept_id": "C3893545", "aliases": [], "types": ["T043"], "canonical_name": "stress response to acid chemical", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049, PMID:19170886, Wikipedia:Acid]"}
{"concept_id": "C3893546", "aliases": [], "types": ["T043"], "canonical_name": "cellular stress response to acid chemical", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049, PMID:19170886, Wikipedia:Acid]"}
{"concept_id": "C3893547", "aliases": [], "types": ["T026"], "canonical_name": "centriolar distal appendage"}
{"concept_id": "C3893548", "aliases": [], "types": ["T026"], "canonical_name": "distal appendage of basal body"}
{"concept_id": "C3893549", "aliases": [], "types": ["T026"], "canonical_name": "distal appendage of centriole"}
{"concept_id": "C3893550", "aliases": [], "types": ["T026"], "canonical_name": "distal appendage of mother centriole"}
{"concept_id": "C3893554", "aliases": ["transverse cilium"], "types": ["T026"], "canonical_name": "transverse flagellum", "definition": "A motile cilium found in dinoflagellates. It coils around the cell and provides the forward thrust for motility. It is often contained in a furrow called the cingulum, and emerges from a flagellar pore located in the cingulum. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]"}
{"concept_id": "C3893555", "aliases": ["longitudinal cilium"], "types": ["T026"], "canonical_name": "longitudinal flagellum", "definition": "A motile cilium found in dinoflagellates. It trails the cell and acts as a steering rudder. It is often partially contained in a furrow called the sulcus, and emerges from a flagellar pore located in the sulcus. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]"}
{"concept_id": "C3893556", "aliases": ["cell surface groove", "cell surface furrow", "furrow"], "types": ["T026"], "definition": "A furrow that may be found on the cell surface. Examples include the cingulum and sulcus found in some dinoflagellates. [GOC:pr]", "canonical_name": "groove"}
{"concept_id": "C3893557", "aliases": [], "types": ["T026"], "canonical_name": "transverse groove"}
{"concept_id": "C3893558", "aliases": ["longitudinal furrow", "sulcus", "longitudinal groove"], "types": ["T026"], "definition": "A cell surface furrow that occurs on the ventral side of a dinoflagellate cell. It partially houses the longitudinal flagellum. The sulcus intersects with the cingulum on the ventral side of a dinoflagellate cell. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]", "canonical_name": "dinoflagellate sulcus"}
{"concept_id": "C3893559", "aliases": ["epicone"], "types": ["T026"], "canonical_name": "dinoflagellate epicone", "definition": "The part of a dinoflagellate cell above the cingulum; also referred to as the anterior portion of a dinoflagellate cell. It is separated from the hypocone by the cingulum. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]"}
{"concept_id": "C3893560", "aliases": [], "types": ["T026"], "canonical_name": "epitheca"}
{"concept_id": "C3893561", "aliases": [], "types": ["T026"], "canonical_name": "dinoflagellate hypocone", "definition": "The part of a dinoflagellate cell below the cingulum; also referred to as the posterior portion of a dinoflagellate cell. It is separated from the epicone by the cingulum. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]"}
{"concept_id": "C3893562", "aliases": [], "types": ["T026"], "canonical_name": "hypocone"}
{"concept_id": "C3893563", "aliases": [], "types": ["T026"], "canonical_name": "hyposome"}
{"concept_id": "C3893564", "aliases": [], "types": ["T026"], "canonical_name": "hypotheca"}
{"concept_id": "C3893565", "aliases": ["modulation by host of bacterial type IV pilus-dependent motility"], "types": ["T043"], "canonical_name": "modulation by host of symbiont type IV pilus-dependent motility", "definition": "The process in which an organism effects a change in the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:als, PMID:12037568]"}
{"concept_id": "C3893566", "aliases": ["positive regulation by host of bacterial type IV pilus-dependent motility"], "types": ["T043"], "canonical_name": "positive regulation by host of symbiont type IV pilus-dependent motility", "definition": "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:als, PMID:12037568]"}
{"concept_id": "C3893568", "aliases": ["sulcal notch", "dinoflagellate sulcus notch"], "types": ["T026"], "canonical_name": "dinoflagellate sulcal notch", "definition": "A dinoflagellate sulcus that extends all the way to the posterior end of the cell (also known as antapex). The presence of a sulcal notch makes the dinoflagellate hypocone appear bilobed. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]"}
{"concept_id": "C3893569", "aliases": ["PTEX complex location"], "types": ["T026"], "canonical_name": "PTEX complex", "definition": "A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components. [GOC:pr, PMID:19536257, PMID:25043010, PMID:25043043]"}
{"concept_id": "C3893570", "aliases": [], "types": ["T026"], "canonical_name": "Plasmodium translocon of exported proteins"}
{"concept_id": "C3893571", "aliases": ["D-mandelate dehydrogenase activity"], "types": ["T044"], "canonical_name": "(R)-mandelate dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor. [GOC:pr, PMID:1731758, RHEA:43112]"}
{"concept_id": "C3893572", "aliases": ["amine:oxygen oxidoreductase (deaminating) activity"], "types": ["T044"], "canonical_name": "monoamine oxidase activity", "definition": "Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. [GOC:pr, RHEA:26414]"}
{"concept_id": "C3893573", "aliases": [], "types": ["T045"], "canonical_name": "cytoplasmic translational elongation through polyproline stretches", "definition": "The successive addition of amino acid residues to a nascent polypeptide chain, proceeding through regions of multiple repeated proline codons, during protein biosynthesis in the cytoplasm. [GOC:mcc, PMID:24923804]"}
{"concept_id": "C3893574", "aliases": ["potassium ion export from cell", "potassium export across plasma membrane"], "types": ["T043"], "canonical_name": "potassium ion export across plasma membrane", "definition": "The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:11932440]"}
{"concept_id": "C3893575", "aliases": ["UDP-galactose import into Golgi lumen"], "types": ["T043"], "canonical_name": "UDP-galactose transmembrane import into Golgi lumen", "definition": "The directed movement of UDP-galactose into the Golgi lumen across the Golgi membrane. [GOC:vw, PMID:11378902]"}
{"concept_id": "C3893576", "aliases": ["low affinity basic amino acid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "low-affinity basic amino acid transmembrane transporter activity", "definition": "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [GOC:pr]"}
{"concept_id": "C3893577", "aliases": ["low affinity L-arginine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "low-affinity L-arginine transmembrane transporter activity", "definition": "Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [GOC:krc, PMID:8195186]"}
{"concept_id": "C3893578", "aliases": ["high affinity L-ornithine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity L-ornithine transmembrane transporter activity", "definition": "Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:krc, PMID:8195186]"}
{"concept_id": "C3893579", "aliases": [], "types": ["T043"], "canonical_name": "distal tip cell migration", "definition": "The orderly movement of a distal tip cell. [CL:0000661, GOC:mm2, PMID:24968003]"}
{"concept_id": "C3893580", "aliases": ["extrinsic to omegasome membrane"], "types": ["T026"], "canonical_name": "extrinsic component of omegasome membrane", "definition": "The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:mf, PMID:18725538, PMID:24591649]"}
{"concept_id": "C3893581", "aliases": [], "types": ["T026"], "canonical_name": "omegasome peripheral membrane"}
{"concept_id": "C3893582", "aliases": ["intrinsic to omegasome membrane"], "types": ["T026"], "canonical_name": "intrinsic component of omegasome membrane", "definition": "The component of the omegasome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:mf, PMID:18725538, PMID:24591649]"}
{"concept_id": "C3893583", "aliases": ["omegasome integral membrane protein", "integral to omegasome membrane"], "types": ["T026"], "canonical_name": "integral component of omegasome membrane", "definition": "The component of the omegasome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:mf, PMID:18725538, PMID:24591649]"}
{"concept_id": "C3893584", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of pre-autophagosomal structure membrane"}
{"concept_id": "C3893585", "aliases": ["intrinsic to phagophore assembly site membrane"], "types": ["T026"], "canonical_name": "intrinsic component of phagophore assembly site membrane", "definition": "The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:mf]"}
{"concept_id": "C3893586", "aliases": [], "types": ["T026"], "canonical_name": "integral component of phagophore assembly site membrane", "definition": "The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:mf]"}
{"concept_id": "C3893587", "aliases": ["autophagic vacuole peripheral membrane", "extrinsic to autophagic vacuole membrane", "extrinsic component of autophagic vacuole membrane"], "types": ["T026"], "canonical_name": "extrinsic component of autophagosome membrane", "definition": "The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C3893588", "aliases": ["intrinsic component of autophagic vacuole membrane", "intrinsic to autophagic vacuole membrane"], "types": ["T026"], "canonical_name": "intrinsic component of autophagosome membrane", "definition": "The component of the autophagosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C3893589", "aliases": ["integral to autophagic vacuole membrane", "autophagic vacuole integral membrane protein", "integral component of autophagic vacuole membrane"], "types": ["T026"], "canonical_name": "integral component of autophagosome membrane", "definition": "The component of the autophagosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C3893590", "aliases": ["L-arginine import into cell"], "types": ["T043"], "canonical_name": "L-arginine import across plasma membrane", "definition": "The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]"}
{"concept_id": "C3893591", "aliases": ["L-lysine import into cell"], "types": ["T043"], "canonical_name": "L-lysine import across plasma membrane", "definition": "The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]"}
{"concept_id": "C3893592", "aliases": ["L-ornithine import into cell"], "types": ["T043"], "canonical_name": "L-ornithine import across plasma membrane", "definition": "The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]"}
{"concept_id": "C3893593", "aliases": ["2-oxoglutarate-dependent xanthine dioxygenase activity", "alpha-ketoglutarate- and Fe(II)-dependent xanthine dioxygenase activity", "alpha-ketoglutarate- and Fe(II)-dependent xanthine hydroxylase activity"], "types": ["T044"], "canonical_name": "alpha-ketoglutarate-dependent xanthine dioxygenase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate. [GOC:vw, PMID:15948966, PMID:17429948, RHEA:43120]"}
{"concept_id": "C3893594", "aliases": [], "types": ["T044"], "canonical_name": "calcitonin family receptor activity", "definition": "Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity. [GOC:bhm, InterPro:IPR003287, PMID:10871296, PMID:12037140, PMID:18687416]"}
{"concept_id": "C3893595", "aliases": [], "types": ["T044"], "canonical_name": "amylin receptor activity", "definition": "Combining with amylin to initiate a change in cell activity. [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]"}
{"concept_id": "C3893596", "aliases": [], "types": ["T044"], "canonical_name": "calcitonin family binding", "definition": "Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)). [GOC:bhm, InterPro:IPR021116, PMID:10871296, PMID:12037140, PMID:18687416]"}
{"concept_id": "C3893597", "aliases": [], "types": ["T044"], "canonical_name": "amylin binding", "definition": "Binding to amylin. [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]"}
{"concept_id": "C3893598", "aliases": ["calcitonin family receptor signalling pathway"], "types": ["T044"], "canonical_name": "calcitonin family receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]"}
{"concept_id": "C3893599", "aliases": ["amilyn receptor signalling pathway"], "types": ["T044"], "canonical_name": "amylin receptor signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]"}
{"concept_id": "C3893600", "aliases": ["G-protein coupled receptor complex", "G protein-coupled receptor complex location", "G-protein coupled receptor complex location"], "types": ["T026"], "canonical_name": "G protein-coupled receptor complex", "definition": "A protein complex that contains G protein-coupled receptors. [GOC:bhm]"}
{"concept_id": "C3893601", "aliases": ["A tubule"], "types": ["T026"], "canonical_name": "A axonemal microtubule", "definition": "A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule. [GOC:cilia, ISBN:0716731363]"}
{"concept_id": "C3893602", "aliases": ["B tubule"], "types": ["T026"], "canonical_name": "B axonemal microtubule", "definition": "An incomplete microtubule containing 10 protofilaments that fuses with a complete microtubule called A tubule (containing 13 protofilaments) to form an axonemal outer doublet. [GOC:cilia, ISBN:0716731363]"}
{"concept_id": "C3893603", "aliases": ["class I PI3K complex", "class I PI3K complex location", "phosphatidylinositol 3-kinase complex location, class I", "class I phosphatidylinositol 3-kinase complex", "class I phosphatidylinositol 3-kinase complex location"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex, class I", "definition": "A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast. [GOC:ha, PMID:24587488]"}
{"concept_id": "C3893604", "aliases": ["class II PI3K complex", "class II phosphatidylinositol 3-kinase complex location", "phosphatidylinositol 3-kinase complex location, class II", "class II phosphatidylinositol 3-kinase complex", "class II PI3K complex location"], "types": ["T026"], "canonical_name": "phosphatidylinositol 3-kinase complex, class II", "definition": "A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast. [GOC:ha, PMID:24587488]"}
{"concept_id": "C3893605", "aliases": ["non-encapsulated part of cell"], "types": ["T026"], "canonical_name": "unencapsulated part of cell", "definition": "The part of a cell encompassing the intracellular environment and the plasma membrane; it excludes any external encapsulating structures. [GOC:curators]"}
{"concept_id": "C3893606", "aliases": ["platelet SNARE complex location"], "types": ["T026"], "canonical_name": "platelet SNARE complex", "definition": "A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4. [GOC:bhm, PMID:12130530, PMID:19450911]"}
{"concept_id": "C3893607", "aliases": [], "types": ["T044"], "canonical_name": "serpin family protein binding", "definition": "Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors. [GOC:mr, InterPro:IPR000215, PMID:16737556]"}
{"concept_id": "C3893608", "aliases": ["kin recognition", "self recognition", "kin discrimination"], "types": ["T043"], "canonical_name": "cell-cell self recognition", "definition": "A cell-cell recognition process by which a cell distinguishes between self and non self during cooperative behavior, such as early development. [GOC:pf, PMID:21700835, PMID:23910661]"}
{"concept_id": "C3893609", "aliases": [], "types": ["T044"], "canonical_name": "3',5'-nucleotide bisphosphate phosphatase activity", "definition": "Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate. [GOC:jh2, PMID:24401123, RHEA:43532]"}
{"concept_id": "C3893610", "aliases": ["Asi complex location"], "types": ["T026"], "canonical_name": "Asi complex", "definition": "A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p. [GOC:mcc, PMID:25236469]"}
{"concept_id": "C3893611", "aliases": [], "types": ["T045"], "canonical_name": "nucleic acid-templated transcription", "definition": "The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA). [GOC:pr, GOC:txnOH, GOC:vw]"}
{"concept_id": "C3893612", "aliases": ["SCF-Cdc4 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Cdc4 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Cdc4 in S. cerevisiae. [GOC:jd, GOC:vw, PMID:9346238]"}
{"concept_id": "C3893613", "aliases": ["SCF-Ctf13 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Ctf13 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Ctf13 in S. cerevisiae. [GOC:jd, GOC:vw, PMID:14747994]"}
{"concept_id": "C3893614", "aliases": ["SCF-Das1 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Das1 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Das1 in S. cerevisiae. [GOC:jd, GOC:vw, PMID:14747994]"}
{"concept_id": "C3893615", "aliases": ["SCF-Dia2/Pof3 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Dia2/Pof3 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe). [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]"}
{"concept_id": "C3893616", "aliases": ["SCF-Grr1/Pof2 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Grr1/Pof2 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Grr1 in S. cerevisiae (Pof2 in S. pombe). [GOC:jd, GOC:vw, PMID:10213692, PMID:15147268]"}
{"concept_id": "C3893617", "aliases": ["SCF-Mdm30 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Mdm30 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Mdm30 in S. cerevisiae. [GOC:jd, GOC:vw, PMID:14747994]"}
{"concept_id": "C3893618", "aliases": ["SCF-Met30/Pof1 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Met30/Pof1 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe). [GOC:jd, GOC:vw, PMID:15147268, PMID:9499404]"}
{"concept_id": "C3893619", "aliases": ["SCF-Rcy1/Pof6 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Rcy1/Pof6 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe). [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]"}
{"concept_id": "C3893620", "aliases": ["SCF-Saf1/Pof9 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Saf1/Pof9 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe). [GOC:jd, GOC:vw, PMID:11283612, PMID:15147268]"}
{"concept_id": "C3893621", "aliases": ["SCF-Skp2 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Skp2 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae. [GOC:jd, GOC:vw, PMID:14747994]"}
{"concept_id": "C3893622", "aliases": ["SCF-Ufo1/Pof10 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Ufo1/Pof10 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Ufo1 in S. cerevisiae (Pof10 in S. pombe). [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]"}
{"concept_id": "C3893623", "aliases": ["SCF-YDR131C ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-YDR131C ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is YDR131C in S. cerevisiae. [GOC:jd, GOC:vw, PMID:14747994]"}
{"concept_id": "C3893624", "aliases": ["SCF-Pof5 ubiquitin ligase complex location", "SCF-YDR306C ubiquitin ligase complex", "SCF-YDR306C ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Pof5 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae). [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]"}
{"concept_id": "C3893625", "aliases": ["SCF-YLR224W ubiquitin ligase complex", "SCF-Ucc1 ubiquitin ligase complex location", "SCF-YLR224W ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Ucc1 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae. [GOC:jd, GOC:vw, PMID:14747994, PMID:25982115]"}
{"concept_id": "C3893626", "aliases": ["SCF-YLR352W ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-YLR352W ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is YLR352W in S. cerevisiae. [GOC:jd, GOC:vw, PMID:19882662]"}
{"concept_id": "C3893627", "aliases": ["SCF-Hrt3/Pof7 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "SCF-Hrt3/Pof7 ubiquitin ligase complex", "definition": "An SCF ubiquitin ligase complex in which the F-box protein is Hrt3 in S. cerevisiae (Pof7 in S. pombe). [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]"}
{"concept_id": "C3893628", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K36 dimethylation", "definition": "The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone. [GOC:lb, PMID:21187428]"}
{"concept_id": "C3893629", "aliases": ["signal transducers and activators of transcription family protein binding"], "types": ["T044"], "canonical_name": "STAT family protein binding", "definition": "Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses. [GOC:mr, InterPro:IPR001217, PMID:21447371, PMID:24470978]"}
{"concept_id": "C3893630", "aliases": ["suppressor of cytokine signaling family protein binding"], "types": ["T044"], "canonical_name": "SOCS family protein binding", "definition": "Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions. [GOC:mr, InterPro:IPR028413, PMID:23885323, PMID:24705897]"}
{"concept_id": "C3893631", "aliases": [], "types": ["T026"], "canonical_name": "other organism cytoplasm"}
{"concept_id": "C3893632", "aliases": ["canonical nonhomologous end joining", "C-NHEJ"], "types": ["T045"], "canonical_name": "double-strand break repair via classical nonhomologous end joining", "definition": "An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining). [GOC:rph, PMID:18584027]"}
{"concept_id": "C3893633", "aliases": ["A-NHEJ", "double-strand break repair via microhomology-mediated end joining", "MMEJ"], "types": ["T045"], "canonical_name": "double-strand break repair via alternative nonhomologous end joining", "definition": "An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment. [GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining]"}
{"concept_id": "C3893634", "aliases": [], "types": ["T045"], "canonical_name": "alt-NHEJ"}
{"concept_id": "C3893635", "aliases": [], "types": ["T044"], "canonical_name": "intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity", "definition": "Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts. [GOC:ha, PMID:24375408]"}
{"concept_id": "C3893636", "aliases": ["antapex"], "types": ["T026"], "canonical_name": "dinoflagellate antapex", "definition": "The anterior most point of a dinoflagellate hypocone. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]"}
{"concept_id": "C3893637", "aliases": ["apical groove"], "types": ["T026"], "canonical_name": "dinoflagellate apical groove", "definition": "A cell surface furrow (or groove) found on a dinoflagellate apex. It typically loops around the apex. [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology]"}
{"concept_id": "C3893638", "aliases": [], "types": ["T026"], "canonical_name": "dinoflagellate apical horn", "definition": "A horn-shaped dinoflagellate apex found in thecate species. [GOC:at, http://species-identification.org]"}
{"concept_id": "C3893639", "aliases": [], "types": ["T026"], "canonical_name": "dinoflagellate antapical horn", "definition": "A horn-shaped dinoflagellate antapex found in thecate species. [GOC:at, http://species-identification.org]"}
{"concept_id": "C3893640", "aliases": ["glutamatergic receptor clustering"], "types": ["T044"], "canonical_name": "glutamate receptor clustering", "definition": "The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane. [GOC:krc, PMID:19723286]"}
{"concept_id": "C3893642", "aliases": ["iron channel inhibitor activity"], "types": ["T044"], "canonical_name": "iron ion transmembrane transporter inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of an iron ion transmembrane transporter. [GOC:BHF, GOC:kom, PMID:15514116]"}
{"concept_id": "C3893643", "aliases": [], "types": ["T043"], "canonical_name": "adhesion between unicellular organisms", "definition": "The attachment of two unicellular organisms to each other. [GOC:dos]"}
{"concept_id": "C3893646", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-proline 4-dioxygenase binding", "definition": "Binding to a peptidyl-proline 4-dioxygenase. [GOC:dos, GOC:kvm]"}
{"concept_id": "C3893647", "aliases": [], "types": ["T026"], "canonical_name": "basement membrane collagen trimer", "definition": "Any collagen timer that is part of a basement membrane. [GOC:dos, PMID:21421911]"}
{"concept_id": "C3893648", "aliases": [], "types": ["T026"], "canonical_name": "collagen type VII anchoring fibril", "definition": "An antiparallel dimer of two collagen VII trimers, one end of which is embedded in the lamina densa while the other end attaches to banded collagen fibrils in the dermis. [PMID:19693541]"}
{"concept_id": "C3893649", "aliases": ["CENP-A recruiting complex location"], "types": ["T026"], "canonical_name": "CENP-A recruiting complex", "definition": "A protein complex that includes Mis16(Yippee family) and/or Mis18 (WD repeat) subunits that is involved in the deposition of centromere specific (CENP-A containing) nucleosomes at the centromere. [PMID:24774534]"}
{"concept_id": "C3893650", "aliases": ["MIS18 complex location"], "types": ["T026"], "canonical_name": "MIS18 complex", "definition": "OBSOLETE. A centromere complex assembly protein that is required for the deposition of CENP-A on the centromere. The Mis18 complex localizes to centromeres just prior to the pre-nucleosomal HJURP/CENP-A/H4 complex and is absolutely required for the CENP-A-specific chaperone, Holliday junction recognition protein (HJURP) to reach the centromeres. Plk1 phosphorylation activates Mis18 complex recruitment to the centromeres during G1. CDK phosphorylation of MISBP1 during G2 and mitosis, prior to the metaphase-to-anaphase transition, negatively regulates complex assembly. [GOC:bhm, PMID:25036634]"}
{"concept_id": "C3893651", "aliases": [], "types": ["T044"], "canonical_name": "cation transmembrane transport", "definition": "The process in which a cation is transported across a membrane. [GOC:dos, GOC:vw]"}
{"concept_id": "C3893652", "aliases": [], "types": ["T043"], "canonical_name": "anion transmembrane transport", "definition": "The process in which an anion is transported across a membrane. [GOC:dos, GOC:vw]"}
{"concept_id": "C3893653", "aliases": ["inorganic anion import into cell"], "types": ["T043"], "canonical_name": "inorganic anion import across plasma membrane", "definition": "The directed movement of inorganic anions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893654", "aliases": ["inorganic cation import into cell"], "types": ["T044"], "canonical_name": "inorganic cation import across plasma membrane", "definition": "The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893655", "aliases": ["transmembrane inorganic ion transport", "inorganic ion membrane transport"], "types": ["T043"], "canonical_name": "inorganic ion transmembrane transport", "definition": "The process in which an inorganic ion is transported across a membrane. [GOC:mah]"}
{"concept_id": "C3893656", "aliases": ["inorganic anion membrane transport", "transmembrane inorganic anion transport"], "types": ["T043"], "canonical_name": "inorganic anion transmembrane transport", "definition": "The process in which an inorganic anion is transported across a membrane. [GOC:mah]"}
{"concept_id": "C3893657", "aliases": ["inorganic cation membrane transport", "transmembrane inorganic cation transport"], "types": ["T043"], "canonical_name": "inorganic cation transmembrane transport", "definition": "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]"}
{"concept_id": "C3893659", "aliases": ["neurotransmitter import into synaptic vesicle", "synaptic vesicle neurotransmitter loading", "neurotransmitter uptake into synaptic vesicle"], "types": ["T043"], "canonical_name": "neurotransmitter loading into synaptic vesicle", "definition": "The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps. [GOC:bf, GOC:pad, GOC:PARL, PMID:10099709, PMID:15217342]"}
{"concept_id": "C3893661", "aliases": ["adenine import into cell"], "types": ["T043"], "canonical_name": "adenine import across plasma membrane", "definition": "The directed movement of adenine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893662", "aliases": ["calcium ion uptake into cell", "calcium ion import into cell"], "types": ["T043"], "canonical_name": "calcium ion import across plasma membrane", "definition": "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893663", "aliases": ["carbohydrate import into cell"], "types": ["T043"], "canonical_name": "carbohydrate import across plasma membrane", "definition": "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893664", "aliases": ["copper ion import into cell", "copper cation import into cell"], "types": ["T043"], "canonical_name": "copper ion import across plasma membrane", "definition": "The directed movement of copper ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893665", "aliases": ["ferric iron import across cell outer membrane", "ferric iron import into cell", "ferric ion import into cell"], "types": ["T043"], "canonical_name": "iron ion import across cell outer membrane", "definition": "The directed movement of iron ions from outside of a cell, across the cell outer membrane and into the periplasmic space. [GOC:mah, PMID:23192658]"}
{"concept_id": "C3893666", "aliases": ["ferrous iron import across plasma membrane", "ferrous iron import into cell"], "types": ["T044"], "canonical_name": "ferrous ion import into cell"}
{"concept_id": "C3893667", "aliases": ["glucose import into cell"], "types": ["T044"], "canonical_name": "glucose import across plasma membrane", "definition": "The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893668", "aliases": ["glutathione uptake", "glutathione import into cell"], "types": ["T043"], "canonical_name": "glutathione import across plasma membrane", "definition": "The directed movement of glutathione from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893669", "aliases": ["guanine import into cell"], "types": ["T043"], "canonical_name": "guanine import across plasma membrane", "definition": "The directed movement of guanine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893670", "aliases": ["iron ion import into cell"], "types": ["T044"], "canonical_name": "iron ion import across plasma membrane", "definition": "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:mah, PMID:8321236]"}
{"concept_id": "C3893671", "aliases": ["L-glutamate(1-) import into cell", "L-glutamate import into cell"], "types": ["T043"], "canonical_name": "L-glutamate import across plasma membrane", "definition": "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893672", "aliases": ["leucine import into cell"], "types": ["T043"], "canonical_name": "leucine import across plasma membrane", "definition": "The directed movement of leucine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893673", "aliases": ["malate import into cell"], "types": ["T043"], "canonical_name": "malate import across plasma membrane", "definition": "The directed movement of malate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893674", "aliases": ["malonic acid import into cell", "malonate import into cell"], "types": ["T043"], "canonical_name": "malonic acid import across plasma membrane", "definition": "The directed movement of malonic acid from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893675", "aliases": ["nickel cation import into cell"], "types": ["T043"], "canonical_name": "nickel cation import across plasma membrane", "definition": "The directed movement of nickel cations from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893676", "aliases": ["pantothenate import into cell"], "types": ["T043"], "canonical_name": "pantothenate import across plasma membrane", "definition": "The directed movement of pantothenate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893677", "aliases": ["serine import into cell"], "types": ["T043"], "canonical_name": "serine import across plasma membrane", "definition": "The directed movement of serine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893678", "aliases": ["sodium import", "sodium ion import into cell"], "types": ["T043"], "canonical_name": "sodium ion import across plasma membrane", "definition": "The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893679", "aliases": ["succinate import into cell"], "types": ["T043"], "canonical_name": "succinate import across plasma membrane", "definition": "The directed movement of succinate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893680", "aliases": ["uracil import into cell"], "types": ["T043"], "canonical_name": "uracil import across plasma membrane", "definition": "The directed movement of uracil from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893681", "aliases": [], "types": ["T026"], "canonical_name": "skeletal muscle myofibril", "definition": "A myofibril of a skeletal muscle fiber. [GOC:dos]"}
{"concept_id": "C3893682", "aliases": [], "types": ["T043"], "canonical_name": "symmetric stem cell division", "definition": "Symmetric division of a stem cell to produce two stem cells of the same type as the parent. Symmetric stem cell division is necessary for amplification of stem cell populations in the absence of sources of stem cells external to an existing population. [PMID:19948499, PMID:23303905]"}
{"concept_id": "C3893683", "aliases": [], "types": ["T043"], "canonical_name": "symmetric cell division", "definition": "Cell division in which both daughter cells are of the same type. [GOC:dos]"}
{"concept_id": "C3893684", "aliases": [], "types": ["T043"], "canonical_name": "symmetric division of skeletal muscle satellite stem cell", "definition": "The symmetric division of a skeletal muscle satellite stem cell, resulting in two skeletal muscle satellite stem cells. This process is involved in amplification of the pool of these cells. [PMID:23303905]"}
{"concept_id": "C3893685", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of cell number", "definition": "Any process by which the numbers of cells of a particular type or in a tissue are maintained. [GOC:dos]"}
{"concept_id": "C3893686", "aliases": [], "types": ["T043"], "canonical_name": "germline stem cell asymmetric division", "definition": "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes. [GOC:dos]"}
{"concept_id": "C3893687", "aliases": [], "types": ["T043"], "canonical_name": "germline stem cell symmetric division", "definition": "Division of a germline stem cell to produce two germline stem cells of the same type as the parent. [GOC:dos, PMID:19948499]"}
{"concept_id": "C3893688", "aliases": [], "types": ["T043"], "canonical_name": "male germline stem cell symmetric division", "definition": "The symmetric division of a male germline stem cell to produce two male germline stem cells. An example of this is found in mammalian spermatogonial stem cells, some proportion of which divide symmetrically, so amplifying the population. The choice between asymmetric and symmetric division in this case appears to be internal and stochastic. [GOC:dos, PMID:19948499]"}
{"concept_id": "C3893689", "aliases": [], "types": ["T043"], "canonical_name": "skeletal muscle satellite stem cell maintenance involved in skeletal muscle regeneration", "definition": "Any process by which the number of skeletal muscle satellite stem cells in a skeletal muscle is maintained during skeletal muscle regeneration. There are at least two mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. [PMID:23303905]"}
{"concept_id": "C3893690", "aliases": [], "types": ["T044"], "canonical_name": "macromolecule deacylation", "definition": "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. [GOC:dos]"}
{"concept_id": "C3893691", "aliases": ["hemidesmosome associated protein complex location"], "types": ["T026"], "canonical_name": "hemidesmosome associated protein complex", "definition": "Any protein complex that is part of or has some part in a hemidesmosome. [GOC:dos]"}
{"concept_id": "C3893692", "aliases": [], "types": ["T044"], "canonical_name": "macromolecule depalmitoylation", "definition": "The removal of palymitoyl groups from a macromolecule. [GOC:dos]"}
{"concept_id": "C3893693", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of the force of heart contraction", "definition": "Any process that increases the force of heart muscle contraction. [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280]"}
{"concept_id": "C3893694", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of the force of heart contraction", "definition": "Any process that decreases the force of heart muscle contraction. [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280]"}
{"concept_id": "C3893695", "aliases": [], "types": ["T043"], "canonical_name": "protein insertion into plasma membrane", "definition": "The process that results in the incorporation of a protein into a plasma membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. [GOC:DOS]"}
{"concept_id": "C3893696", "aliases": ["uptake"], "types": ["T043"], "definition": "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]", "canonical_name": "import across plasma membrane"}
{"concept_id": "C3893698", "aliases": [], "types": ["T043"], "canonical_name": "adhesion between unicellular organisms via cell-wall interaction"}
{"concept_id": "C3893699", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion via plasma-membrane adhesion molecules", "definition": "The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. [GOC:dos]"}
{"concept_id": "C3893700", "aliases": [], "types": ["T044"], "canonical_name": "1-phosphatidylinositol 4-kinase activator activity", "definition": "Binds to and increases the activity of 1-phosphatidylinositol 4-kinase. [PMID:21288895]"}
{"concept_id": "C3893701", "aliases": ["Dcp1-Dcp2 complex location"], "types": ["T026"], "canonical_name": "Dcp1-Dcp2 complex", "definition": "A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA. [GOC:dos, GOC:vw, PMID:22323607]"}
{"concept_id": "C3893702", "aliases": ["synchronous, calcium ion-dependent exocytosis of neurotransmitter"], "types": ["T043"], "canonical_name": "fast, calcium ion-dependent exocytosis of neurotransmitter", "definition": "The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release. [GOC:dos, GOC:pad, GOC:PARL, PMID:4405553, PMID:7809151, PMID:7954835]"}
{"concept_id": "C3893703", "aliases": [], "types": ["T043"], "canonical_name": "slow, calcium ion-dependent exocytosis of neurotransmitter", "definition": "The slow, second phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on high affinity calcium sensors and decays slowly, typically with a decay constant of over 100ms. The underlying molecular mechanisms of this process are distinct from those of the earlier, fast phase of release. [GOC:dos, GOC:pad, GOC:parl, PMID:7809151, PMID:7954835]"}
{"concept_id": "C3893704", "aliases": [], "types": ["T044"], "canonical_name": "endocytic adaptor activity"}
{"concept_id": "C3893705", "aliases": [], "types": ["T043"], "canonical_name": "cerebellar neuron development", "definition": "The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dos]"}
{"concept_id": "C3893706", "aliases": [], "types": ["T044"], "canonical_name": "FYXD domain binding", "definition": "Binding to a FXYD domain. [GOC:dos, GOC:mr, PMID:10950925, PMID:16403837, PMID:18000745]"}
{"concept_id": "C3893707", "aliases": [], "types": ["T043"], "canonical_name": "bone cell development", "definition": "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dos]"}
{"concept_id": "C3893708", "aliases": [], "types": ["T026"], "canonical_name": "integral component of the cytoplasmic side of the plasma membrane", "definition": "The component of the plasma membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane. [GOC:dos]"}
{"concept_id": "C3893709", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of the cytoplasmic side of the plasma membrane", "definition": "The component of the plasma membrane consisting of gene products and protein complexes with covalently attached hydrophobic anchors products that penetrate only the cytoplasmic side of the membrane. [GOC:dos]"}
{"concept_id": "C3893710", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of seed dormancy by absisic acid", "definition": "The process by which seed dormancy is maintained by the presence of absisic acid. [GOC:dos, PMID:9580097]"}
{"concept_id": "C3893711", "aliases": [], "types": ["T043"], "canonical_name": "meiotic cell cycle phase", "definition": "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. [GOC:dos]"}
{"concept_id": "C3893712", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cell cycle phase", "definition": "One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. [GOC:dos]"}
{"concept_id": "C3893713", "aliases": [], "types": ["T043"], "canonical_name": "meiosis I cell cycle phase", "definition": "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs. [GOC:dos]"}
{"concept_id": "C3893714", "aliases": [], "types": ["T043"], "canonical_name": "meiosis II cell cycle phase", "definition": "A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division). [GOC:dos]"}
{"concept_id": "C3893717", "aliases": [], "types": ["T043"], "canonical_name": "meiotic prometaphase I", "definition": "The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate. [PMID:16012859]"}
{"concept_id": "C3893718", "aliases": [], "types": ["T044"], "canonical_name": "TIMP family protein binding", "definition": "Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family. [PMID:22078297]"}
{"concept_id": "C3893719", "aliases": [], "types": ["T044"], "canonical_name": "FBXO family protein binding", "definition": "Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction. [PMID:11178263]"}
{"concept_id": "C3893720", "aliases": [], "types": ["T039"], "canonical_name": "inorganic ion homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell. [GOC:dos]"}
{"concept_id": "C3893721", "aliases": ["molecular function regulator"], "types": ["T044"], "canonical_name": "molecular function regulator activity", "definition": "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition. [GOC:dos, GOC:pt]"}
{"concept_id": "C3893722", "aliases": [], "types": ["T042"], "canonical_name": "skin epidermis development", "definition": "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. [GOC:dos]"}
{"concept_id": "C3893723", "aliases": [], "types": ["T026"], "canonical_name": "curli", "definition": "A proteinaceous extracellular fiber, produced by an enteric bacterium, that is involved in surface and cell-cell contacts that promote community behavior and host colonization. [PMID:16704339]"}
{"concept_id": "C3893724", "aliases": [], "types": ["T044"], "canonical_name": "curli assembly", "definition": "The process of assembly of curli, extracellular fibers produced by enteric bacteria. This process occurs outside the cell, where it is coupled to secretion across the cell outer membrane via nucleation by elements of the transporter complex. [PMID:16704339]"}
{"concept_id": "C3893725", "aliases": [], "types": ["T043"], "canonical_name": "protein transport across the cell outer membrane", "definition": "The directed movement of proteins across the cell outer membrane. [GOC:dos]"}
{"concept_id": "C3893726", "aliases": ["T8SS"], "types": ["T043"], "canonical_name": "protein secretion by the type VIII secretion system", "definition": "Protein secretion through the outer membrane via the mechanism used for the secretion of curli subunits. [PMID:19299134, PMID:24080089]"}
{"concept_id": "C3893727", "aliases": ["extracellular nucleation-precipitation pathway"], "types": ["T043"], "canonical_name": "curli subunit secretion coupled to curli assembly", "definition": "The secretion of soluble curli subunits through the outer membrane, coupled to nucleation of curli fiber formation at the membrane surface. [PMID:24080089]"}
{"concept_id": "C3893728", "aliases": ["positive regulation of macromitophagy in response to mitochondrial depolarization"], "types": ["T043"], "canonical_name": "positive regulation of mitophagy in response to mitochondrial depolarization", "definition": "Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization. [GOC:PARL, PMID:18200046, PMID:23985961]"}
{"concept_id": "C3893729", "aliases": [], "types": ["T043"], "canonical_name": "response to mitochondrial depolarisation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. [GOC:dos]"}
{"concept_id": "C3893730", "aliases": [], "types": ["T045"], "canonical_name": "ncRNA transcription", "definition": "The transcription of non (protein) coding RNA from a DNA template. [GOC:dos]"}
{"concept_id": "C3893731", "aliases": ["mechanically-gated potassium channel activity"], "types": ["T044"], "canonical_name": "mechanosensitived potassium channel activity", "definition": "Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress. [PMID:22282805, PMID:25471887, PMID:25500157]"}
{"concept_id": "C3893733", "aliases": ["biofilm matrix organization and biogenesis"], "types": ["T043"], "canonical_name": "biofilm matrix organization", "definition": "A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix. [GOC:mah]"}
{"concept_id": "C3893734", "aliases": [], "types": ["T043"], "canonical_name": "biofilm matrix assembly", "definition": "A process that results in the assembly of a biofilm matrix. [GOC:mah]"}
{"concept_id": "C3893735", "aliases": [], "types": ["T043"], "canonical_name": "biofilm matrix disassembly", "definition": "A process that results in the disassembly of a biofilm matrix. [GOC:mah]"}
{"concept_id": "C3893736", "aliases": ["apical dendritic knob"], "types": ["T026"], "canonical_name": "dendritic knob", "definition": "The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium. [PMID:20801626]"}
{"concept_id": "C3893737", "aliases": ["Golgi subcompartment"], "types": ["T026"], "canonical_name": "Golgi apparatus subcompartment", "definition": "A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus. [GOC:dos]"}
{"concept_id": "C3893738", "aliases": [], "types": ["T038"], "canonical_name": "regulation of renal system process", "definition": "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. [GOC:dos]"}
{"concept_id": "C3893739", "aliases": ["inorganic ion import into cell"], "types": ["T043"], "canonical_name": "inorganic ion import across plasma membrane", "definition": "The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]"}
{"concept_id": "C3893740", "aliases": [], "types": ["T040"], "canonical_name": "regulation of skeletal muscle contraction by action potential", "definition": "Any action potential process that regulates skeletal muscle contraction. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893741", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein kinase activity by protein phosphorylation", "definition": "Any protein phosphorylation process that negatively regulates protein kinase activity. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893747", "aliases": [], "types": ["T044"], "canonical_name": "regulation of fever generation by prostaglandin biosynthetic process", "definition": "Any prostaglandin biosynthetic process process that regulates fever generation. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893748", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fever generation by prostaglandin secretion", "definition": "Any prostaglandin secretion process that regulates fever generation. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893749", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of fever generation by prostaglandin biosynthetic process", "definition": "Any prostaglandin biosynthetic process process that positively_regulates fever generation. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893750", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of fever generation by prostaglandin secretion", "definition": "Any prostaglandin secretion process that positively_regulates fever generation. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893751", "aliases": [], "types": ["T043"], "canonical_name": "regulation of heart induction by canonical Wnt signaling pathway", "definition": "Any canonical Wnt signaling pathway process that regulates heart induction. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893765", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA repair by transcription from RNA polymerase II promoter", "definition": "Any transcription from RNA polymerase II promoter process that positively regulates DNA repair. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893784", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter", "definition": "Any transcription from RNA polymerase II promoter process that negatively regulates arginine catabolic process. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893806", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway", "definition": "Any canonical Wnt signaling pathway process that positively_regulates spinal cord association neuron differentiation. [GOC:cjm, GOC:obol]"}
{"concept_id": "C3893811", "aliases": ["regulation of physiological response to wounding"], "types": ["T039"], "canonical_name": "regulation of response to wounding", "definition": "Any process that modulates the frequency, rate or extent of response to wounding. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535]"}
{"concept_id": "C3893812", "aliases": ["inhibition of physiological response to wounding", "down-regulation of response to wounding", "negative regulation of physiological response to wounding", "inhibition of response to wounding", "down-regulation of physiological response to wounding", "down regulation of physiological response to wounding", "downregulation of physiological response to wounding", "downregulation of response to wounding", "down regulation of response to wounding"], "types": ["T039"], "canonical_name": "negative regulation of response to wounding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535]"}
{"concept_id": "C3893813", "aliases": ["activation of response to wounding", "up-regulation of physiological response to wounding", "upregulation of response to wounding", "up-regulation of response to wounding", "up regulation of response to wounding", "positive regulation of physiological response to wounding", "up regulation of physiological response to wounding", "upregulation of physiological response to wounding", "activation of physiological response to wounding"], "types": ["T039"], "canonical_name": "positive regulation of response to wounding", "definition": "Any process that activates or increases the frequency, rate or extent of response to wounding. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535]"}
{"concept_id": "C3893814", "aliases": ["regulation of leukocyte cell adhesion", "regulation of leukocyte adhesion"], "types": ["T043"], "canonical_name": "regulation of leukocyte cell-cell adhesion", "definition": "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]"}
{"concept_id": "C3893815", "aliases": ["inhibition of leukocyte cell-cell adhesion", "inhibition of leukocyte adhesion", "down-regulation of leukocyte adhesion", "downregulation of leukocyte cell adhesion", "downregulation of leukocyte cell-cell adhesion", "down regulation of leukocyte cell-cell adhesion", "negative regulation of leukocyte adhesion", "negative regulation of leukocyte cell adhesion", "down-regulation of leukocyte cell-cell adhesion", "inhibition of leukocyte cell adhesion", "down regulation of leukocyte cell adhesion", "downregulation of leukocyte adhesion", "down-regulation of leukocyte cell adhesion", "down regulation of leukocyte adhesion"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte cell-cell adhesion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]"}
{"concept_id": "C3893816", "aliases": ["upregulation of leukocyte adhesion", "up regulation of leukocyte adhesion", "upregulation of leukocyte cell-cell adhesion", "up regulation of leukocyte cell-cell adhesion", "up regulation of leukocyte cell adhesion", "positive regulation of leukocyte cell adhesion", "up-regulation of leukocyte adhesion", "up-regulation of leukocyte cell adhesion", "activation of leukocyte cell adhesion", "activation of leukocyte adhesion", "up-regulation of leukocyte cell-cell adhesion", "positive regulation of leukocyte adhesion", "upregulation of leukocyte cell adhesion", "activation of leukocyte cell-cell adhesion"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte cell-cell adhesion", "definition": "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]"}
{"concept_id": "C3893817", "aliases": ["EJC assembly", "EJC formation", "exon-exon junction complex formation"], "types": ["T044"], "canonical_name": "exon-exon junction complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an exon-exon junction complex. [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:17606899]"}
{"concept_id": "C3893818", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chondrocyte hypertrophy", "definition": "Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032]"}
{"concept_id": "C3893819", "aliases": ["inhibition of chondrocyte hypertrophy", "down regulation of chondrocyte hypertrophy", "down-regulation of chondrocyte hypertrophy", "downregulation of chondrocyte hypertrophy"], "types": ["T043"], "canonical_name": "negative regulation of chondrocyte hypertrophy", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032]"}
{"concept_id": "C3893820", "aliases": ["activation of chondrocyte hypertrophy", "up regulation of chondrocyte hypertrophy", "up-regulation of chondrocyte hypertrophy", "upregulation of chondrocyte hypertrophy"], "types": ["T043"], "canonical_name": "positive regulation of chondrocyte hypertrophy", "definition": "Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032]"}
{"concept_id": "C3893821", "aliases": ["protein localisation in membrane raft", "protein localisation to membrane raft", "protein localization in membrane raft"], "types": ["T043"], "canonical_name": "protein localization to membrane raft", "definition": "A process in which a protein is transported to, or maintained in, a location within a membrane raft. [GO_REF:0000087, GOC:dl, GOC:TermGenie, PMID:19414744]"}
{"concept_id": "C3893822", "aliases": [], "types": ["T043"], "canonical_name": "neural crest cell migration involved in sympathetic nervous system development", "definition": "Any neural crest cell migration that is involved in sympathetic nervous system development. [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19325129]"}
{"concept_id": "C3893823", "aliases": [], "types": ["T043"], "canonical_name": "meiotic cell cycle process", "definition": "A process that is part of the meiotic cell cycle. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3893824", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cell cycle process", "definition": "A process that is part of the mitotic cell cycle. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3893825", "aliases": [], "types": ["T038"], "canonical_name": "regulation of acetylcholine-gated cation channel activity", "definition": "Any process that modulates the frequency, rate or extent of acetylcholine-gated cation channel activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690]"}
{"concept_id": "C3893826", "aliases": ["down-regulation of acetylcholine-gated cation channel activity", "inhibition of acetylcholine-gated cation channel activity", "downregulation of acetylcholine-gated cation channel activity", "down regulation of acetylcholine-gated cation channel activity"], "types": ["T038"], "canonical_name": "negative regulation of acetylcholine-gated cation channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine-gated cation channel activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690]"}
{"concept_id": "C3893827", "aliases": ["regulation of proteolysis during cellular protein catabolic process", "regulation of peptidolysis involved in cellular protein catabolic process", "regulation of peptidolysis during cellular protein catabolic process", "regulation of proteolysis involved in cellular protein catabolic process", "regulation of peptidolysis involved in cellular protein catabolism", "regulation of peptidolysis during cellular protein catabolism", "regulation of proteolysis during cellular protein catabolism"], "types": ["T044"], "canonical_name": "regulation of proteolysis involved in protein catabolic process", "definition": "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]"}
{"concept_id": "C3893828", "aliases": ["down-regulation of peptidolysis during cellular protein catabolism", "down regulation of proteolysis during cellular protein catabolic process", "downregulation of peptidolysis during cellular protein catabolic process", "inhibition of peptidolysis during cellular protein catabolism", "downregulation of proteolysis during cellular protein catabolism", "downregulation of proteolysis involved in cellular protein catabolic process", "down-regulation of proteolysis involved in cellular protein catabolic process", "inhibition of proteolysis during cellular protein catabolism", "down-regulation of proteolysis during cellular protein catabolic process", "downregulation of peptidolysis involved in cellular protein catabolism", "down regulation of proteolysis during cellular protein catabolism", "negative regulation of peptidolysis during cellular protein catabolism", "downregulation of proteolysis during cellular protein catabolic process", "downregulation of peptidolysis involved in cellular protein catabolic process", "inhibition of peptidolysis involved in cellular protein catabolism", "negative regulation of proteolysis during cellular protein catabolism", "negative regulation of peptidolysis involved in cellular protein catabolism", "down-regulation of peptidolysis during cellular protein catabolic process", "down regulation of peptidolysis during cellular protein catabolic process", "down regulation of peptidolysis involved in cellular protein catabolic process", "negative regulation of peptidolysis involved in cellular protein catabolic process", "inhibition of proteolysis during cellular protein catabolic process", "down regulation of proteolysis involved in cellular protein catabolic process", "inhibition of peptidolysis during cellular protein catabolic process", "down-regulation of proteolysis during cellular protein catabolism", "down-regulation of peptidolysis involved in cellular protein catabolism", "negative regulation of proteolysis during cellular protein catabolic process", "down-regulation of peptidolysis involved in cellular protein catabolic process", "negative regulation of proteolysis involved in cellular protein catabolic process", "down regulation of peptidolysis involved in cellular protein catabolism", "inhibition of proteolysis involved in cellular protein catabolic process", "downregulation of peptidolysis during cellular protein catabolism", "down regulation of peptidolysis during cellular protein catabolism", "inhibition of peptidolysis involved in cellular protein catabolic process", "negative regulation of peptidolysis during cellular protein catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of proteolysis involved in protein catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]"}
{"concept_id": "C3893829", "aliases": ["activation of proteolysis involved in cellular protein catabolic process", "up regulation of proteolysis during cellular protein catabolic process", "positive regulation of peptidolysis during cellular protein catabolic process", "up regulation of peptidolysis during cellular protein catabolism", "positive regulation of proteolysis involved in cellular protein catabolic process", "up-regulation of proteolysis involved in cellular protein catabolic process", "up-regulation of proteolysis during cellular protein catabolic process", "up-regulation of peptidolysis involved in cellular protein catabolic process", "up regulation of peptidolysis involved in cellular protein catabolic process", "upregulation of peptidolysis involved in cellular protein catabolic process", "positive regulation of proteolysis during cellular protein catabolic process", "positive regulation of peptidolysis involved in cellular protein catabolic process", "positive regulation of peptidolysis during cellular protein catabolism", "activation of proteolysis during cellular protein catabolic process", "activation of proteolysis during cellular protein catabolism", "positive regulation of peptidolysis involved in cellular protein catabolism", "up-regulation of proteolysis during cellular protein catabolism", "up-regulation of peptidolysis involved in cellular protein catabolism", "upregulation of peptidolysis during cellular protein catabolism", "up regulation of proteolysis involved in cellular protein catabolic process", "up-regulation of peptidolysis during cellular protein catabolism", "activation of peptidolysis during cellular protein catabolic process", "upregulation of peptidolysis involved in cellular protein catabolism", "upregulation of peptidolysis during cellular protein catabolic process", "activation of peptidolysis involved in cellular protein catabolism", "positive regulation of proteolysis during cellular protein catabolism", "upregulation of proteolysis during cellular protein catabolism", "upregulation of proteolysis involved in cellular protein catabolic process", "activation of peptidolysis involved in cellular protein catabolic process", "up regulation of proteolysis during cellular protein catabolism", "activation of peptidolysis during cellular protein catabolism", "up regulation of peptidolysis involved in cellular protein catabolism", "up regulation of peptidolysis during cellular protein catabolic process", "up-regulation of peptidolysis during cellular protein catabolic process", "upregulation of proteolysis during cellular protein catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of proteolysis involved in protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]"}
{"concept_id": "C3893830", "aliases": ["regulation of extracellular matrix organization and biogenesis", "regulation of extracellular matrix organisation"], "types": ["T043"], "canonical_name": "regulation of extracellular matrix organization", "definition": "Any process that modulates the frequency, rate or extent of extracellular matrix organization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]"}
{"concept_id": "C3893831", "aliases": ["down-regulation of extracellular matrix organisation", "negative regulation of extracellular matrix organisation", "inhibition of extracellular matrix organization", "downregulation of extracellular matrix organization", "down regulation of extracellular matrix organization", "down-regulation of extracellular matrix organization", "inhibition of extracellular matrix organisation", "down regulation of extracellular matrix organisation", "downregulation of extracellular matrix organisation"], "types": ["T043"], "canonical_name": "negative regulation of extracellular matrix organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]"}
{"concept_id": "C3893832", "aliases": ["down-regulation of extracellular matrix organization and biogenesis", "downregulation of extracellular matrix organization and biogenesis", "inhibition of extracellular matrix organization and biogenesis", "negative regulation of extracellular matrix organization and biogenesis"], "types": ["T043"], "canonical_name": "down regulation of extracellular matrix organization and biogenesis"}
{"concept_id": "C3893833", "aliases": ["up regulation of extracellular matrix organization", "upregulation of extracellular matrix organization", "upregulation of extracellular matrix organisation", "up-regulation of extracellular matrix organization", "activation of extracellular matrix organization", "positive regulation of extracellular matrix organisation", "activation of extracellular matrix organisation", "up-regulation of extracellular matrix organisation", "up regulation of extracellular matrix organisation"], "types": ["T043"], "canonical_name": "positive regulation of extracellular matrix organization", "definition": "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]"}
{"concept_id": "C3893834", "aliases": ["positive regulation of extracellular matrix organization and biogenesis", "up-regulation of extracellular matrix organization and biogenesis", "up regulation of extracellular matrix organization and biogenesis", "upregulation of extracellular matrix organization and biogenesis"], "types": ["T043"], "canonical_name": "activation of extracellular matrix organization and biogenesis"}
{"concept_id": "C3893835", "aliases": ["regulation of melanosome organisation", "regulation of melanosome organization and biogenesis"], "types": ["T043"], "canonical_name": "regulation of melanosome organization", "definition": "Any process that modulates the frequency, rate or extent of melanosome organization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727]"}
{"concept_id": "C3893836", "aliases": ["down-regulation of melanosome organization", "downregulation of melanosome organization and biogenesis", "down regulation of melanosome organization", "down regulation of melanosome organization and biogenesis", "down-regulation of melanosome organisation", "negative regulation of melanosome organisation", "down regulation of melanosome organisation", "downregulation of melanosome organisation", "down-regulation of melanosome organization and biogenesis", "negative regulation of melanosome organization and biogenesis", "downregulation of melanosome organization", "inhibition of melanosome organization and biogenesis"], "types": ["T043"], "canonical_name": "negative regulation of melanosome organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome organization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727]"}
{"concept_id": "C3893837", "aliases": ["inhibition of melanosome organization"], "types": ["T043"], "canonical_name": "inhibition of melanosome organisation"}
{"concept_id": "C3893838", "aliases": ["up-regulation of melanosome organisation", "upregulation of melanosome organisation", "positive regulation of melanosome organization and biogenesis", "up regulation of melanosome organization and biogenesis", "activation of melanosome organization and biogenesis", "upregulation of melanosome organization", "up regulation of melanosome organization", "up-regulation of melanosome organization and biogenesis", "upregulation of melanosome organization and biogenesis", "positive regulation of melanosome organisation", "up-regulation of melanosome organization", "up regulation of melanosome organisation"], "types": ["T043"], "canonical_name": "positive regulation of melanosome organization", "definition": "Any process that activates or increases the frequency, rate or extent of melanosome organization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727]"}
{"concept_id": "C3893839", "aliases": ["activation of melanosome organization"], "types": ["T043"], "canonical_name": "activation of melanosome organisation"}
{"concept_id": "C3893840", "aliases": ["regulation of lipid:protein modification", "regulation of protein amino acid lipidation"], "types": ["T044"], "canonical_name": "regulation of protein lipidation", "definition": "Any process that modulates the frequency, rate or extent of protein lipidation. [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]"}
{"concept_id": "C3893841", "aliases": ["down regulation of protein amino acid lipidation", "down regulation of lipid:protein modification", "downregulation of protein lipidation", "negative regulation of lipid:protein modification", "downregulation of protein amino acid lipidation", "down-regulation of lipid:protein modification", "down regulation of protein lipidation", "down-regulation of protein lipidation", "inhibition of lipid:protein modification", "downregulation of lipid:protein modification", "down-regulation of protein amino acid lipidation", "inhibition of protein lipidation", "inhibition of protein amino acid lipidation", "negative regulation of protein amino acid lipidation"], "types": ["T044"], "canonical_name": "negative regulation of protein lipidation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation. [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]"}
{"concept_id": "C3893842", "aliases": ["positive regulation of protein amino acid lipidation", "activation of lipid:protein modification", "up-regulation of protein lipidation", "up-regulation of protein amino acid lipidation", "positive regulation of lipid:protein modification", "activation of protein lipidation", "upregulation of lipid:protein modification", "up regulation of protein amino acid lipidation", "up regulation of protein lipidation", "upregulation of protein lipidation", "up regulation of lipid:protein modification", "upregulation of protein amino acid lipidation", "up-regulation of lipid:protein modification", "activation of protein amino acid lipidation"], "types": ["T044"], "canonical_name": "positive regulation of protein lipidation", "definition": "Any process that activates or increases the frequency, rate or extent of protein lipidation. [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]"}
{"concept_id": "C3893843", "aliases": [], "types": ["T044"], "canonical_name": "regulation of reverse cholesterol transport", "definition": "Any process that modulates the frequency, rate or extent of reverse cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754]"}
{"concept_id": "C3893844", "aliases": ["down-regulation of reverse cholesterol transport", "downregulation of reverse cholesterol transport", "down regulation of reverse cholesterol transport", "inhibition of reverse cholesterol transport"], "types": ["T044"], "canonical_name": "negative regulation of reverse cholesterol transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of reverse cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754]"}
{"concept_id": "C3893845", "aliases": ["upregulation of reverse cholesterol transport", "up-regulation of reverse cholesterol transport", "up regulation of reverse cholesterol transport", "activation of reverse cholesterol transport"], "types": ["T044"], "canonical_name": "positive regulation of reverse cholesterol transport", "definition": "Any process that activates or increases the frequency, rate or extent of reverse cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754]"}
{"concept_id": "C3893847", "aliases": ["regulation of protein localisation to cell tip"], "types": ["T039"], "canonical_name": "regulation of protein localization to cell tip", "definition": "Any process that modulates the frequency, rate or extent of protein localization to cell tip. [GO_REF:0000058, GOC:TermGenie, PMID:24554432]"}
{"concept_id": "C3893848", "aliases": ["down-regulation of protein localisation to cell tip", "downregulation of protein localisation to cell tip", "down regulation of protein localization to cell tip", "down regulation of protein localisation to cell tip", "negative regulation of protein localisation to cell tip", "down-regulation of protein localization to cell tip", "downregulation of protein localization to cell tip"], "types": ["T039"], "canonical_name": "negative regulation of protein localization to cell tip", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell tip. [GO_REF:0000058, GOC:TermGenie, PMID:24554432]"}
{"concept_id": "C3893849", "aliases": ["inhibition of protein localization to cell tip"], "types": ["T039"], "canonical_name": "inhibition of protein localisation to cell tip"}
{"concept_id": "C3893850", "aliases": ["up-regulation of protein localisation to cell tip", "activation of protein localization to cell tip", "upregulation of protein localisation to cell tip", "activation of protein localisation to cell tip", "up regulation of protein localisation to cell tip", "positive regulation of protein localisation to cell tip", "up regulation of protein localization to cell tip", "up-regulation of protein localization to cell tip", "upregulation of protein localization to cell tip"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to cell tip", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to cell tip. [GO_REF:0000058, GOC:TermGenie, PMID:24554432]"}
{"concept_id": "C3893851", "aliases": ["regulation of ER-associated protein breakdown", "regulation of endoplasmic reticulum-associated protein catabolic process", "regulation of ER-associated protein catabolism", "regulation of ER-associated protein degradation", "regulation of ERAD", "regulation of endoplasmic reticulum-associated protein catabolism", "regulation of ER-associated protein catabolic process"], "types": ["T043"], "canonical_name": "regulation of ER-associated ubiquitin-dependent protein catabolic process", "definition": "Any process that modulates the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process. [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946]"}
{"concept_id": "C3893852", "aliases": ["down regulation of ERAD", "negative regulation of endoplasmic reticulum-associated protein catabolic process", "downregulation of endoplasmic reticulum-associated protein catabolic process", "negative regulation of ER-associated protein catabolism", "downregulation of ER-associated protein catabolic process", "down-regulation of ER-associated protein breakdown", "inhibition of ER-associated protein breakdown", "inhibition of endoplasmic reticulum-associated protein catabolism", "negative regulation of ER-associated protein breakdown", "down regulation of ER-associated protein degradation", "down regulation of endoplasmic reticulum-associated protein catabolic process", "down regulation of ER-associated protein breakdown", "negative regulation of ERAD", "down-regulation of endoplasmic reticulum-associated protein catabolism", "inhibition of endoplasmic reticulum-associated protein catabolic process", "negative regulation of ER-associated protein degradation", "downregulation of ER-associated protein degradation", "down-regulation of ERAD", "inhibition of ER-associated protein catabolism", "inhibition of ER-associated protein degradation", "inhibition of ERAD", "downregulation of ER-associated ubiquitin-dependent protein catabolic process", "downregulation of ERAD", "inhibition of ER-associated ubiquitin-dependent protein catabolic process", "down regulation of ER-associated ubiquitin-dependent protein catabolic process", "downregulation of ER-associated protein catabolism", "down-regulation of ER-associated protein degradation", "down-regulation of endoplasmic reticulum-associated protein catabolic process", "downregulation of ER-associated protein breakdown", "down regulation of endoplasmic reticulum-associated protein catabolism", "down-regulation of ER-associated protein catabolic process", "inhibition of ER-associated protein catabolic process", "downregulation of endoplasmic reticulum-associated protein catabolism", "negative regulation of endoplasmic reticulum-associated protein catabolism", "down regulation of ER-associated protein catabolism", "negative regulation of ER-associated protein catabolic process", "down-regulation of ER-associated ubiquitin-dependent protein catabolic process", "down-regulation of ER-associated protein catabolism", "down regulation of ER-associated protein catabolic process"], "types": ["T043"], "canonical_name": "negative regulation of ER-associated ubiquitin-dependent protein catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process. [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946]"}
{"concept_id": "C3893853", "aliases": ["up-regulation of ER-associated protein breakdown", "positive regulation of endoplasmic reticulum-associated protein catabolism", "up regulation of endoplasmic reticulum-associated protein catabolic process", "up-regulation of ER-associated protein catabolism", "up regulation of ER-associated ubiquitin-dependent protein catabolic process", "up-regulation of ER-associated protein degradation", "upregulation of ER-associated protein breakdown", "positive regulation of ER-associated protein degradation", "up regulation of endoplasmic reticulum-associated protein catabolism", "up-regulation of ER-associated protein catabolic process", "up regulation of ERAD", "upregulation of ER-associated protein degradation", "up regulation of ER-associated protein catabolic process", "positive regulation of ER-associated protein breakdown", "up regulation of ER-associated protein breakdown", "upregulation of ER-associated protein catabolism", "up-regulation of endoplasmic reticulum-associated protein catabolism", "positive regulation of ER-associated protein catabolism", "upregulation of ER-associated protein catabolic process", "up regulation of ER-associated protein degradation", "upregulation of endoplasmic reticulum-associated protein catabolic process", "upregulation of ER-associated ubiquitin-dependent protein catabolic process", "positive regulation of ERAD", "positive regulation of ER-associated protein catabolic process", "upregulation of ERAD", "upregulation of endoplasmic reticulum-associated protein catabolism", "up-regulation of ERAD", "positive regulation of endoplasmic reticulum-associated protein catabolic process", "up regulation of ER-associated protein catabolism", "up-regulation of ER-associated ubiquitin-dependent protein catabolic process", "up-regulation of endoplasmic reticulum-associated protein catabolic process"], "types": ["T043"], "canonical_name": "positive regulation of ER-associated ubiquitin-dependent protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process. [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946]"}
{"concept_id": "C3893854", "aliases": ["activation of ER-associated ubiquitin-dependent protein catabolic process", "activation of ER-associated protein catabolic process", "activation of endoplasmic reticulum-associated protein catabolic process", "activation of ER-associated protein catabolism", "activation of ER-associated protein degradation", "activation of ERAD", "activation of endoplasmic reticulum-associated protein catabolism"], "types": ["T043"], "canonical_name": "activation of ER-associated protein breakdown"}
{"concept_id": "C3893855", "aliases": ["regulation of DISC assembly", "regulation of death-inducing signaling complex formation", "regulation of death domain-mediated complex assembly", "regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway", "regulation of DISC formation", "regulation of death-inducing signalling complex assembly", "regulation of DD-mediated complex assembly"], "types": ["T040"], "canonical_name": "regulation of death-inducing signaling complex assembly", "definition": "Any process that modulates the frequency, rate or extent of death-inducing signaling complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]"}
{"concept_id": "C3893856", "aliases": ["down-regulation of DISC assembly", "down-regulation of DISC formation", "negative regulation of DISC formation", "negative regulation of DD-mediated complex assembly", "downregulation of death-inducing signaling complex assembly", "down regulation of DD-mediated complex assembly", "downregulation of DD-mediated complex assembly", "down regulation of death-inducing signalling complex assembly", "inhibition of death-inducing signaling complex assembly", "down regulation of DISC formation", "downregulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway", "down-regulation of death domain-mediated complex assembly", "down regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway", "negative regulation of death-inducing signaling complex formation", "down-regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway", "downregulation of DISC assembly", "down regulation of DISC assembly", "negative regulation of death-inducing signalling complex assembly", "down regulation of death-inducing signaling complex formation", "negative regulation of DISC assembly", "down-regulation of death-inducing signalling complex assembly", "down-regulation of death-inducing signaling complex formation", "down regulation of death domain-mediated complex assembly", "negative regulation of death domain-mediated complex assembly", "inhibition of death-inducing signalling complex assembly", "down-regulation of DD-mediated complex assembly", "downregulation of death-inducing signaling complex formation", "down regulation of death-inducing signaling complex assembly", "down-regulation of death-inducing signaling complex assembly", "downregulation of death domain-mediated complex assembly", "downregulation of DISC formation", "downregulation of death-inducing signalling complex assembly", "negative regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway"], "types": ["T043"], "canonical_name": "negative regulation of death-inducing signaling complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]"}
{"concept_id": "C3893857", "aliases": ["inhibition of death domain-mediated complex assembly involved in extrinsic apoptotic pathway", "inhibition of death domain-mediated complex assembly", "inhibition of DISC assembly", "inhibition of death-inducing signaling complex formation", "inhibition of DISC formation"], "types": ["T043"], "canonical_name": "inhibition of DD-mediated complex assembly"}
{"concept_id": "C3893858", "aliases": ["TRAIL death-inducing signalling complex assembly", "TRAIL DISC assembly", "TRAIL DISC formation", "TRAIL death-inducing signaling complex formation", "TRAIL death-inducing signalling complex formation"], "types": ["T044"], "canonical_name": "TRAIL death-inducing signaling complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a TRAIL death-inducing signaling complex. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]"}
{"concept_id": "C3893859", "aliases": ["pyridoxine import into cell"], "types": ["T043"], "canonical_name": "pyridoxine import across plasma membrane", "definition": "The directed movement of pyridoxine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:15701794]"}
{"concept_id": "C3893860", "aliases": ["regulation of protein localization in plasma membrane", "regulation of protein localisation in plasma membrane"], "types": ["T043"], "canonical_name": "regulation of protein localization to plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]"}
{"concept_id": "C3893861", "aliases": ["downregulation of protein localization to plasma membrane", "down-regulation of protein localization to plasma membrane", "downregulation of protein localisation in plasma membrane", "down regulation of protein localization to plasma membrane", "down-regulation of protein localization in plasma membrane", "downregulation of protein localization in plasma membrane", "negative regulation of protein localisation in plasma membrane", "negative regulation of protein localization in plasma membrane", "down-regulation of protein localisation in plasma membrane", "down regulation of protein localisation in plasma membrane", "down regulation of protein localization in plasma membrane"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]"}
{"concept_id": "C3893862", "aliases": ["inhibition of protein localization to plasma membrane", "inhibition of protein localization in plasma membrane"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in plasma membrane"}
{"concept_id": "C3893863", "aliases": ["up-regulation of protein localisation in plasma membrane", "activation of protein localization to plasma membrane", "activation of protein localisation in plasma membrane", "up-regulation of protein localization in plasma membrane", "up regulation of protein localisation in plasma membrane", "up regulation of protein localization to plasma membrane", "upregulation of protein localization in plasma membrane", "upregulation of protein localization to plasma membrane", "up-regulation of protein localization to plasma membrane", "activation of protein localization in plasma membrane", "up regulation of protein localization in plasma membrane", "positive regulation of protein localization in plasma membrane", "upregulation of protein localisation in plasma membrane", "positive regulation of protein localisation in plasma membrane"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]"}
{"concept_id": "C3893866", "aliases": ["regulation of C-C chemokine receptor CCR7 signalling pathway", "regulation of CCR7 signaling pathway"], "types": ["T044"], "canonical_name": "regulation of C-C chemokine receptor CCR7 signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]"}
{"concept_id": "C3893867", "aliases": ["down regulation of C-C chemokine receptor CCR7 signalling pathway", "down-regulation of C-C chemokine receptor CCR7 signalling pathway", "inhibition of CCR7 signaling pathway", "downregulation of C-C chemokine receptor CCR7 signaling pathway", "down regulation of C-C chemokine receptor CCR7 signaling pathway", "negative regulation of C-C chemokine receptor CCR7 signalling pathway", "down-regulation of CCR7 signaling pathway", "down-regulation of C-C chemokine receptor CCR7 signaling pathway", "negative regulation of CCR7 signaling pathway", "downregulation of C-C chemokine receptor CCR7 signalling pathway", "down regulation of CCR7 signaling pathway", "downregulation of CCR7 signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of C-C chemokine receptor CCR7 signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]"}
{"concept_id": "C3893868", "aliases": ["inhibition of C-C chemokine receptor CCR7 signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of C-C chemokine receptor CCR7 signaling pathway"}
{"concept_id": "C3893869", "aliases": ["activation of CCR7 signaling pathway", "up regulation of C-C chemokine receptor CCR7 signaling pathway", "upregulation of CCR7 signaling pathway", "up regulation of CCR7 signaling pathway", "positive regulation of C-C chemokine receptor CCR7 signalling pathway", "up-regulation of CCR7 signaling pathway", "up regulation of C-C chemokine receptor CCR7 signalling pathway", "upregulation of C-C chemokine receptor CCR7 signaling pathway", "positive regulation of CCR7 signaling pathway", "up-regulation of C-C chemokine receptor CCR7 signalling pathway", "upregulation of C-C chemokine receptor CCR7 signalling pathway", "up-regulation of C-C chemokine receptor CCR7 signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of C-C chemokine receptor CCR7 signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]"}
{"concept_id": "C3893870", "aliases": ["activation of C-C chemokine receptor CCR7 signalling pathway"], "types": ["T044"], "canonical_name": "activation of C-C chemokine receptor CCR7 signaling pathway"}
{"concept_id": "C3893871", "aliases": ["protein localisation to condensed chromosome", "protein localization in condensed chromosome", "protein localisation in condensed chromosome"], "types": ["T043"], "canonical_name": "protein localization to condensed chromosome", "definition": "A process in which a protein is transported to, or maintained in, a location within a condensed chromosome. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312]"}
{"concept_id": "C3893872", "aliases": ["protein localization in condensed nuclear chromosome", "protein localisation to condensed nuclear chromosome", "protein localisation in condensed nuclear chromosome"], "types": ["T043"], "canonical_name": "protein localization to condensed nuclear chromosome", "definition": "A process in which a protein is transported to, or maintained in, a location within a condensed nuclear chromosome. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312]"}
{"concept_id": "C3893873", "aliases": ["regulation of sinapate ester formation", "regulation of sinapate ester synthesis", "regulation of sinapate ester anabolism", "regulation of sinapate ester biosynthesis"], "types": ["T044"], "canonical_name": "regulation of sinapate ester biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of sinapate ester biosynthesis. [GO_REF:0000058, GOC:TermGenie, PMID:11080161]"}
{"concept_id": "C3893874", "aliases": ["negative regulation of sinapate ester anabolism", "down-regulation of sinapate ester formation", "downregulation of sinapate ester synthesis", "down-regulation of sinapate ester anabolism", "down regulation of sinapate ester biosynthesis", "negative regulation of sinapate ester biosynthesis", "down regulation of sinapate ester formation", "down-regulation of sinapate ester biosynthesis", "down regulation of sinapate ester biosynthetic process", "negative regulation of sinapate ester formation", "downregulation of sinapate ester biosynthesis", "inhibition of sinapate ester anabolism", "downregulation of sinapate ester biosynthetic process", "inhibition of sinapate ester biosynthesis", "inhibition of sinapate ester formation", "down regulation of sinapate ester synthesis", "inhibition of sinapate ester synthesis", "down-regulation of sinapate ester biosynthetic process", "negative regulation of sinapate ester synthesis", "inhibition of sinapate ester biosynthetic process", "downregulation of sinapate ester anabolism", "down regulation of sinapate ester anabolism", "downregulation of sinapate ester formation", "down-regulation of sinapate ester synthesis"], "types": ["T044"], "canonical_name": "negative regulation of sinapate ester biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sinapate ester biosynthesis. [GO_REF:0000058, GOC:TermGenie, PMID:11080161]"}
{"concept_id": "C3893875", "aliases": ["spindle pole body assembly involved in mitotic cell cycle", "spindle pole body formation involved in mitotic cell cycle", "spindle pole body duplication in cytoplasm involved in mitotic cell cycle", "spindle pole body duplication involved in mitotic cell cycle", "spindle pole body biosynthesis involved in mitotic cell cycle", "spindle pole body duplication associated with nuclear envelope involved in mitotic cell cycle", "spindle pole body replication involved in mitotic cell cycle", "spindle pole body biogenesis involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "mitotic spindle pole body duplication", "definition": "Any spindle pole body duplication that is involved in the mitotic cell cycle. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3893876", "aliases": [], "types": ["T043"], "canonical_name": "5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport", "definition": "The process in which 5-amino-1-ribofuranosylimidazole-4-carboxamide is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:24778186]"}
{"concept_id": "C3893877", "aliases": ["acadesine transporter activity"], "types": ["T044"], "canonical_name": "5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity", "definition": "Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other. [GO_REF:0000066, GOC:TermGenie, PMID:24778186]"}
{"concept_id": "C3893878", "aliases": [], "types": ["T043"], "canonical_name": "pyridoxal transmembrane transport", "definition": "The process in which pyridoxal is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:15701794]"}
{"concept_id": "C3893879", "aliases": [], "types": ["T043"], "canonical_name": "pyridoxamine transmembrane transport", "definition": "The process in which pyridoxamine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:15701794]"}
{"concept_id": "C3893880", "aliases": [], "types": ["T043"], "canonical_name": "pyridoxine transmembrane transport", "definition": "The process in which pyridoxine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:15701794]"}
{"concept_id": "C3893881", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein K48-linked deubiquitination", "definition": "Any process that modulates the frequency, rate or extent of protein K48-linked deubiquitination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3893882", "aliases": ["downregulation of protein K48-linked deubiquitination", "down-regulation of protein K48-linked deubiquitination", "inhibition of protein K48-linked deubiquitination", "down regulation of protein K48-linked deubiquitination"], "types": ["T044"], "canonical_name": "negative regulation of protein K48-linked deubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21097510]"}
{"concept_id": "C3893883", "aliases": ["ribonuclease III complex location"], "types": ["T026"], "canonical_name": "ribonuclease III complex", "definition": "A protein complex which is capable of ribonuclease III activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22393237]"}
{"concept_id": "C3893884", "aliases": ["protein localization in meiotic spindle midzone", "protein localisation to meiotic spindle midzone", "protein localisation in meiotic spindle midzone"], "types": ["T043"], "canonical_name": "protein localization to meiotic spindle midzone", "definition": "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312]"}
{"concept_id": "C3893892", "aliases": ["1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolism"], "types": ["T044"], "canonical_name": "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process", "definition": "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]"}
{"concept_id": "C3893893", "aliases": ["1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate breakdown", "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolism", "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate degradation"], "types": ["T044"], "canonical_name": "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]"}
{"concept_id": "C3893894", "aliases": ["1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate formation", "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis", "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthesis", "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate anabolism"], "types": ["T044"], "canonical_name": "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]"}
{"concept_id": "C3893895", "aliases": ["potassium:proton antiporter complex location"], "types": ["T026"], "canonical_name": "potassium:proton antiporter complex", "definition": "A protein complex which is capable of potassium:proton antiporter activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:21041667]"}
{"concept_id": "C3893903", "aliases": ["daf-2 receptor signaling pathway involved in dauer larval development", "insulin receptor signalling pathway involved in dauer larval development"], "types": ["T044"], "canonical_name": "insulin receptor signaling pathway involved in dauer larval development", "definition": "Any insulin receptor signaling pathway that is involved in dauer larval development. [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19853560]"}
{"concept_id": "C3893904", "aliases": ["regulation of transcription from mitochondrial promoter"], "types": ["T045"], "canonical_name": "regulation of mitochondrial transcription", "definition": "Any process that modulates the frequency, rate or extent of transcription occuring in the mitochondrion. [GO_REF:0000058, GOC:TermGenie, PMID:21357609]"}
{"concept_id": "C3893905", "aliases": ["upregulation of transcription from mitochondrial promoter", "up regulation of mitochondrial transcription", "activation of transcription from mitochondrial promoter", "upregulation of mitochondrial transcription", "activation of mitochondrial transcription", "up regulation of transcription from mitochondrial promoter", "positive regulation of transcription from mitochondrial promoter", "up-regulation of mitochondrial transcription", "up-regulation of transcription from mitochondrial promoter"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial transcription", "definition": "Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion. [GO_REF:0000058, GOC:TermGenie, PMID:21357609]"}
{"concept_id": "C3893906", "aliases": [], "types": ["T043"], "canonical_name": "regulation of single-strand break repair via homologous recombination", "definition": "Any process that modulates the frequency, rate or extent of single-strand break repair via homologous recombination. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919]"}
{"concept_id": "C3893907", "aliases": ["down-regulation of single-strand break repair via homologous recombination", "down regulation of single-strand break repair via homologous recombination", "downregulation of single-strand break repair via homologous recombination", "inhibition of single-strand break repair via homologous recombination"], "types": ["T045"], "canonical_name": "negative regulation of single-strand break repair via homologous recombination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of single-strand break repair via homologous recombination. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919]"}
{"concept_id": "C3893908", "aliases": ["up regulation of single-strand break repair via homologous recombination", "upregulation of single-strand break repair via homologous recombination", "activation of single-strand break repair via homologous recombination", "up-regulation of single-strand break repair via homologous recombination"], "types": ["T045"], "canonical_name": "positive regulation of single-strand break repair via homologous recombination", "definition": "Any process that activates or increases the frequency, rate or extent of single-strand break repair via homologous recombination. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919]"}
{"concept_id": "C3893909", "aliases": ["copper ion transmembrane transporter complex location"], "types": ["T026"], "canonical_name": "copper ion transmembrane transporter complex", "definition": "A protein complex which is capable of copper ion transmembrane transporter activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23122209]"}
{"concept_id": "C3893910", "aliases": ["silver ion transmembrane transporter complex location"], "types": ["T026"], "canonical_name": "silver ion transmembrane transporter complex", "definition": "A protein complex which is capable of silver ion transmembrane transporter activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11283292]"}
{"concept_id": "C3893911", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament-based movement", "definition": "Any process that modulates the frequency, rate or extent of actin filament-based movement. [GO_REF:0000058, GOC:TermGenie, PMID:24798735]"}
{"concept_id": "C3893912", "aliases": ["up-regulation of actin filament-based movement", "up regulation of actin filament-based movement", "upregulation of actin filament-based movement", "activation of actin filament-based movement"], "types": ["T043"], "canonical_name": "positive regulation of actin filament-based movement", "definition": "Any process that activates or increases the frequency, rate or extent of actin filament-based movement. [GO_REF:0000058, GOC:TermGenie, PMID:24798735]"}
{"concept_id": "C3893913", "aliases": ["regulation of actin filament organisation of cytokinesis, actomyosin contractile ring assembly", "regulation of actin filament organization of contractile ring assembly", "regulation of actin filament organization of cytokinesis, contractile ring assembly", "regulation of actin filament organisation of contractile ring assembly", "regulation of actin filament organization of cytokinesis, actomyosin contractile ring assembly", "regulation of actin filament organisation of cytokinesis, contractile ring assembly", "regulation of actin filament organization of constriction ring assembly", "regulation of actin filament organisation of constriction ring assembly"], "types": ["T043"], "canonical_name": "regulation of actin filament organization involved in cytokinetic actomyosin contractile ring assembly", "definition": "Any process that modulates the frequency, rate or extent of actin filament organization involved in cytokinetic actomyosin contractile ring assembly. [GO_REF:0000058, GOC:TermGenie, PMID:24798735]"}
{"concept_id": "C3893914", "aliases": ["regulation of actin filament organization of cytokinesis, actomyosin contractile ring formation"], "types": ["T043"], "canonical_name": "regulation of actin filament organisation of cytokinesis, actomyosin contractile ring formation"}
{"concept_id": "C3893915", "aliases": ["regulation of regulation of actin filament localization of cytokinesis, contractile ring assembly", "regulation of regulation of actin filament localization of constriction ring assembly", "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation", "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly", "regulation of actin filament organization of cytokinesis, actomyosin ring biosynthesis", "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring formation", "regulation of regulation of actin filament localization of contractile ring assembly", "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis"], "types": ["T043"], "canonical_name": "regulation of actin filament organisation of cytokinesis, actomyosin ring biosynthesis"}
{"concept_id": "C3893916", "aliases": ["regulation of actin filament organization of cytokinesis, actomyosin ring formation"], "types": ["T043"], "canonical_name": "regulation of actin filament organisation of cytokinesis, actomyosin ring formation"}
{"concept_id": "C3893917", "aliases": [], "types": ["T038"], "canonical_name": "urate homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of urate within an organism or cell. [GO_REF:0000072, GOC:dph, GOC:TermGenie, PMID:22306318]"}
{"concept_id": "C3893918", "aliases": ["protein localization in actin cytoskeleton", "protein localisation in actin cytoskeleton", "protein localisation to actin cytoskeleton"], "types": ["T043"], "canonical_name": "protein localization to actin cytoskeleton", "definition": "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. [GO_REF:0000087, GOC:TermGenie, PMID:24798735]"}
{"concept_id": "C3893919", "aliases": ["protein localization to actin cable", "protein localisation in actin filament bundle", "protein localization in actin filament bundle", "protein localisation to actin filament bundle"], "types": ["T043"], "canonical_name": "protein localization to actin filament bundle", "definition": "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. [GO_REF:0000087, GOC:TermGenie, PMID:24798735]"}
{"concept_id": "C3893920", "aliases": ["regulation of TRAIL-activated extrinsic apoptotic signaling pathway", "regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "regulation of TRAIL-induced apoptotic signaling pathway"], "types": ["T044"], "canonical_name": "regulation of TRAIL-activated apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3893921", "aliases": ["negative regulation of TRAIL-activated extrinsic apoptotic signaling pathway", "down-regulation of TRAIL-activated apoptotic signaling pathway", "down regulation of TRAIL-activated apoptotic signaling pathway", "down-regulation of TRAIL-induced apoptotic signaling pathway", "downregulation of TRAIL-induced apoptotic signaling pathway", "inhibition of TRAIL-activated apoptotic signaling pathway", "inhibition of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "negative regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "down regulation of TRAIL-activated extrinsic apoptotic signaling pathway", "down regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "negative regulation of TRAIL-induced apoptotic signaling pathway", "inhibition of TRAIL-induced apoptotic signaling pathway", "down-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "downregulation of TRAIL-activated extrinsic apoptotic signaling pathway", "down-regulation of TRAIL-activated extrinsic apoptotic signaling pathway", "downregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "inhibition of TRAIL-activated extrinsic apoptotic signaling pathway", "down regulation of TRAIL-induced apoptotic signaling pathway", "downregulation of TRAIL-activated apoptotic signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of TRAIL-activated apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]"}
{"concept_id": "C3893922", "aliases": ["regulation of TrxPx activity", "regulation of thiol peroxidase activity", "regulation of TPx activity"], "types": ["T044"], "canonical_name": "regulation of thioredoxin peroxidase activity", "definition": "Any process that modulates the frequency, rate or extent of thioredoxin peroxidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3893923", "aliases": ["inhibition of thioredoxin peroxidase activity", "negative regulation of thiol peroxidase activity", "negative regulation of TPx activity", "downregulation of thioredoxin peroxidase activity", "downregulation of TPx activity", "down-regulation of thiol peroxidase activity", "negative regulation of TrxPx activity", "downregulation of TrxPx activity", "down-regulation of TPx activity", "down regulation of TPx activity", "down-regulation of TrxPx activity", "down regulation of TrxPx activity", "down regulation of thioredoxin peroxidase activity", "down regulation of thiol peroxidase activity", "inhibition of thiol peroxidase activity", "down-regulation of thioredoxin peroxidase activity", "downregulation of thiol peroxidase activity"], "types": ["T044"], "canonical_name": "negative regulation of thioredoxin peroxidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of thioredoxin peroxidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687]"}
{"concept_id": "C3893924", "aliases": ["inhibition of TrxPx activity"], "types": ["T044"], "canonical_name": "inhibition of TPx activity"}
{"concept_id": "C3893925", "aliases": ["negative regulation of thiol peroxidase activity by peptidyl-threonine phosphorylation", "negative regulation of TrxPx activity by peptidyl-threonine phosphorylation", "negative regulation of TPx activity by peptidyl-threonine phosphorylation"], "types": ["T044"], "canonical_name": "negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation", "definition": "A peptidyl-threonine phosphorylation that results in negative regulation of thioredoxin peroxidase activity. [GO_REF:0000063, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687]"}
{"concept_id": "C3893926", "aliases": ["downregulation of centriole-centriole cohesion", "down regulation of centriole-centriole cohesion", "down-regulation of centriole-centriole cohesion", "inhibition of centriole-centriole cohesion"], "types": ["T043"], "canonical_name": "negative regulation of centriole-centriole cohesion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434]"}
{"concept_id": "C3893927", "aliases": ["up-regulation of centriole-centriole cohesion", "activation of centriole-centriole cohesion", "upregulation of centriole-centriole cohesion", "up regulation of centriole-centriole cohesion"], "types": ["T043"], "canonical_name": "positive regulation of centriole-centriole cohesion", "definition": "Any process that activates or increases the frequency, rate or extent of centriole-centriole cohesion. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434]"}
{"concept_id": "C3893932", "aliases": ["up-regulation of L-leucine import into cell", "upregulation of L-leucine import into cell"], "types": ["T043"], "canonical_name": "up regulation of L-leucine import into cell"}
{"concept_id": "C3893933", "aliases": [], "types": ["T043"], "canonical_name": "mononuclear cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]"}
{"concept_id": "C3893934", "aliases": [], "types": ["T038"], "canonical_name": "regulation of tube lumen cavitation", "definition": "Any process that modulates the frequency, rate or extent of tube lumen cavitation. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778]"}
{"concept_id": "C3893935", "aliases": ["inhibition of tube lumen cavitation"], "types": ["T039"], "canonical_name": "negative regulation of tube lumen cavitation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tube lumen cavitation. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778]"}
{"concept_id": "C3893937", "aliases": ["Cu(II) binding", "Cu(2+) binding", "copper(2+)binding"], "types": ["T044"], "canonical_name": "cupric ion binding", "definition": "Binding to a cupric ion, copper(2+). [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]"}
{"concept_id": "C3893938", "aliases": ["copper(1+) binding", "Cu(+) binding", "Cu(I) binding"], "types": ["T044"], "canonical_name": "cuprous ion binding", "definition": "Binding to a cuprous ion, copper(1+). [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]"}
{"concept_id": "C3893939", "aliases": ["regulation of MAPK cascade involved in cell wall organization or biogenesis", "regulation of cell wall biogenesis, MAPKKK cascade", "regulation of cell integrity MAPK pathway", "regulation of MAPKKK cascade involved in cell wall biogenesis"], "types": ["T044"], "canonical_name": "regulation of cell wall integrity MAPK cascade", "definition": "Any process that modulates the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:23934882]"}
{"concept_id": "C3893940", "aliases": ["regulation of Mpk1 cascade", "regulation of Slt2 cascade", "regulation of PMK1-MAPK signal transduction pathway", "regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway", "regulation of Pmk1 MAPK cell integrity signaling"], "types": ["T044"], "canonical_name": "regulation of MAPK cascade involved in cell wall biogenesis"}
{"concept_id": "C3893941", "aliases": ["downregulation of MAPK cascade involved in cell wall organization or biogenesis", "negative regulation of cell integrity MAPK pathway", "down regulation of MAPKKK cascade involved in cell wall biogenesis", "down regulation of PMK1-MAPK signal transduction pathway", "negative regulation of cell wall biogenesis, MAPKKK cascade", "negative regulation of MAPK cascade involved in cell wall organization or biogenesis", "down-regulation of MAPKKK cascade involved in cell wall biogenesis", "down-regulation of PMK1-MAPK signal transduction pathway", "negative regulation of MAPKKK cascade involved in cell wall biogenesis", "down-regulation of cell wall biogenesis, MAPKKK cascade", "downregulation of MAPKKK cascade involved in cell wall biogenesis", "down regulation of cell integrity MAPK pathway", "down-regulation of MAPK cascade involved in cell wall organization or biogenesis", "down-regulation of cell integrity MAPK pathway", "downregulation of cell wall biogenesis, MAPKKK cascade", "down regulation of MAPK cascade involved in cell wall organization or biogenesis", "downregulation of cell integrity MAPK pathway", "down regulation of cell wall biogenesis, MAPKKK cascade"], "types": ["T044"], "canonical_name": "negative regulation of cell wall integrity MAPK cascade", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:23934882]"}
{"concept_id": "C3893942", "aliases": ["down regulation of Pmk1 MAPK cell integrity signaling", "inhibition of Mpk1 cascade", "down-regulation of Slt2 cascade", "inhibition of Slt2 cascade", "negative regulation of PMK1-MAPK signal transduction pathway", "downregulation of MAPK cascade involved in cell wall biogenesis", "down regulation of Mpk1 cascade", "down-regulation of MAPK cascade involved in cell wall biogenesis", "negative regulation of MAPK cascade involved in cell wall biogenesis", "negative regulation of Mpk1 cascade", "inhibition of Pmk1 MAPK cell integrity signaling", "downregulation of PMK1-MAPK signal transduction pathway", "negative regulation of Slt2 cascade", "negative regulation of Pmk1 MAPK cell integrity signaling", "down-regulation of Mpk1 cascade", "inhibition of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway", "down-regulation of Pmk1 MAPK cell integrity signaling", "inhibition of PMK1-MAPK signal transduction pathway", "inhibition of MAPK cascade involved in cell wall biogenesis", "inhibition of MAPK cascade involved in cell wall organization or biogenesis", "inhibition of MAPKKK cascade involved in cell wall biogenesis", "down regulation of Slt2 cascade", "negative regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway", "downregulation of Mpk1 cascade", "inhibition of cell integrity MAPK pathway", "downregulation of Pmk1 MAPK cell integrity signaling", "downregulation of Slt2 cascade", "downregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway", "inhibition of cell wall biogenesis, MAPKKK cascade"], "types": ["T044"], "canonical_name": "down regulation of MAPK cascade involved in cell wall biogenesis"}
{"concept_id": "C3893943", "aliases": ["down-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway"], "types": ["T044"], "canonical_name": "down regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway"}
{"concept_id": "C3893944", "aliases": ["upregulation of cell wall biogenesis, MAPKKK cascade", "positive regulation of Pmk1 MAPK cell integrity signaling", "up-regulation of MAPK cascade involved in cell wall organization or biogenesis", "upregulation of MAPK cascade involved in cell wall organization or biogenesis", "activation of MAPKKK cascade involved in cell wall biogenesis", "activation of MAPK cascade involved in cell wall biogenesis", "up regulation of MAPK cascade involved in cell wall organization or biogenesis", "positive regulation of Mpk1 cascade", "up-regulation of MAPKKK cascade involved in cell wall biogenesis", "positive regulation of MAPK cascade involved in cell wall organization or biogenesis", "up regulation of MAPKKK cascade involved in cell wall biogenesis", "activation of PMK1-MAPK signal transduction pathway", "activation of Slt2 cascade", "activation of Pmk1 MAPK cell integrity signaling", "upregulation of MAPKKK cascade involved in cell wall biogenesis", "activation of cell wall biogenesis, MAPKKK cascade", "positive regulation of cell integrity MAPK pathway", "upregulation of cell integrity MAPK pathway", "activation of Mpk1 cascade", "upregulation of Pmk1 MAPK cell integrity signaling", "up-regulation of cell wall biogenesis, MAPKKK cascade", "positive regulation of PMK1-MAPK signal transduction pathway", "up regulation of cell integrity MAPK pathway", "activation of cell integrity MAPK pathway", "positive regulation of MAPKKK cascade involved in cell wall biogenesis", "up-regulation of Slt2 cascade", "up regulation of Slt2 cascade", "activation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway", "positive regulation of cell wall biogenesis, MAPKKK cascade", "positive regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway", "upregulation of PMK1-MAPK signal transduction pathway", "up regulation of Mpk1 cascade", "upregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway", "up-regulation of MAPK cascade involved in cell wall biogenesis", "up-regulation of cell integrity MAPK pathway", "positive regulation of Slt2 cascade", "up regulation of cell wall biogenesis, MAPKKK cascade", "positive regulation of MAPK cascade involved in cell wall biogenesis", "up-regulation of Pmk1 MAPK cell integrity signaling", "up regulation of MAPK cascade involved in cell wall biogenesis", "upregulation of Slt2 cascade", "up-regulation of Mpk1 cascade", "upregulation of Mpk1 cascade", "activation of MAPK cascade involved in cell wall organization or biogenesis", "upregulation of MAPK cascade involved in cell wall biogenesis", "up regulation of Pmk1 MAPK cell integrity signaling"], "types": ["T044"], "canonical_name": "positive regulation of cell wall integrity MAPK cascade", "definition": "Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:23934882]"}
{"concept_id": "C3893945", "aliases": ["up-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway"], "types": ["T044"], "canonical_name": "up regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway"}
{"concept_id": "C3893946", "aliases": ["up-regulation of PMK1-MAPK signal transduction pathway"], "types": ["T044"], "canonical_name": "up regulation of PMK1-MAPK signal transduction pathway"}
{"concept_id": "C3893947", "aliases": [], "types": ["T043"], "canonical_name": "regulation of establishment of endothelial barrier", "definition": "Any process that modulates the frequency, rate or extent of establishment of endothelial barrier. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]"}
{"concept_id": "C3893948", "aliases": ["down regulation of establishment of endothelial barrier", "down-regulation of establishment of endothelial barrier", "downregulation of establishment of endothelial barrier", "inhibition of establishment of endothelial barrier"], "types": ["T043"], "canonical_name": "negative regulation of establishment of endothelial barrier", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]"}
{"concept_id": "C3893949", "aliases": ["up-regulation of establishment of endothelial barrier", "up regulation of establishment of endothelial barrier", "upregulation of establishment of endothelial barrier", "activation of establishment of endothelial barrier"], "types": ["T043"], "canonical_name": "positive regulation of establishment of endothelial barrier", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]"}
{"concept_id": "C3893950", "aliases": ["adrenomedullin receptor AM1 complex location", "adrenomedullin receptor complex location", "adrenomedullin receptor AM1 complex", "adrenomedullin receptor AM2 complex location", "adrenomedullin receptor AM2 complex"], "types": ["T026"], "canonical_name": "adrenomedullin receptor complex", "definition": "A transmembrane, G protein-coupled signalling receptor complex which is capable of adrenomedullin receptor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22102369]"}
{"concept_id": "C3893951", "aliases": ["actin filament of CAR", "actin filament of actomyosin ring", "actin filament of actomyosin contractile ring", "actin filament of contractile actomyosin ring", "actin filament of cytokinetic ring"], "types": ["T026"], "canonical_name": "actomyosin contractile ring actin filament", "definition": "Any actin filament that is part of a actomyosin contractile ring. [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052]"}
{"concept_id": "C3893952", "aliases": ["actin filament of cell cortex of cell end", "microfilament of cell cortex of cell tip", "microfilament of cell cortex of cell end"], "types": ["T026"], "canonical_name": "actin filament of cell cortex of cell tip", "definition": "Any actin filament that is part of a cell cortex of cell tip. [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052]"}
{"concept_id": "C3893953", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrion degradation"}
{"concept_id": "C3893954", "aliases": ["inhibition of mitophagy"], "types": ["T043"], "canonical_name": "inhibition of mitochondrion degradation"}
{"concept_id": "C3893974", "aliases": [], "types": ["T043"], "canonical_name": "response to polycyclic arene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501]"}
{"concept_id": "C3893975", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to polycyclic arene", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501]"}
{"concept_id": "C3893976", "aliases": ["regulation of L-proline oxidase activity", "regulation of 1-pyrroline-5-carboxylate reductase activity", "regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity", "regulation of L-proline:NAD(P)+ 5-oxidoreductase activity", "regulation of L-proline-NAD(P)+ 5-oxidoreductase activity", "regulation of P5CR activity"], "types": ["T044"], "canonical_name": "regulation of pyrroline-5-carboxylate reductase activity", "definition": "Any process that modulates the frequency, rate or extent of pyrroline-5-carboxylate reductase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3893977", "aliases": ["upregulation of L-proline-NAD(P)+ 5-oxidoreductase activity", "positive regulation of L-proline:NAD(P)+ 5-oxidoreductase activity", "up regulation of L-proline:NAD(P)+ 5-oxidoreductase activity", "up regulation of P5CR activity", "upregulation of P5CR activity", "positive regulation of L-proline-NAD(P)+ 5-oxidoreductase activity", "up-regulation of L-proline oxidase activity", "upregulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity", "up-regulation of P5CR activity", "up-regulation of L-proline:NAD(P)+ 5-oxidoreductase activity", "up regulation of L-proline-NAD(P)+ 5-oxidoreductase activity", "positive regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity", "up regulation of L-proline oxidase activity", "upregulation of L-proline oxidase activity", "positive regulation of L-proline oxidase activity", "up-regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity", "positive regulation of 1-pyrroline-5-carboxylate reductase activity", "up-regulation of L-proline-NAD(P)+ 5-oxidoreductase activity", "upregulation of L-proline:NAD(P)+ 5-oxidoreductase activity", "up regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity", "up regulation of pyrroline-5-carboxylate reductase activity", "activation of 1-pyrroline-5-carboxylate reductase activity", "upregulation of pyrroline-5-carboxylate reductase activity", "up-regulation of 1-pyrroline-5-carboxylate reductase activity", "up-regulation of pyrroline-5-carboxylate reductase activity", "up regulation of 1-pyrroline-5-carboxylate reductase activity", "upregulation of 1-pyrroline-5-carboxylate reductase activity", "positive regulation of P5CR activity"], "types": ["T044"], "canonical_name": "positive regulation of pyrroline-5-carboxylate reductase activity", "definition": "Any process that activates or increases the frequency, rate or extent of pyrroline-5-carboxylate reductase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23743200]"}
{"concept_id": "C3893978", "aliases": ["activation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity"], "types": ["T044"], "canonical_name": "activation of L-proline oxidase activity"}
{"concept_id": "C3893979", "aliases": ["activation of L-proline:NAD(P)+ 5-oxidoreductase activity"], "types": ["T044"], "canonical_name": "activation of L-proline-NAD(P)+ 5-oxidoreductase activity"}
{"concept_id": "C3893980", "aliases": ["activation of pyrroline-5-carboxylate reductase activity"], "types": ["T044"], "canonical_name": "activation of P5CR activity"}
{"concept_id": "C3893981", "aliases": ["regulation of calcium ion membrane transport", "regulation of transmembrane calcium transport"], "types": ["T043"], "canonical_name": "regulation of calcium ion transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]"}
{"concept_id": "C3893982", "aliases": ["down-regulation of calcium ion transmembrane transport", "down regulation of transmembrane calcium transport", "down-regulation of transmembrane calcium transport", "down regulation of calcium ion membrane transport", "down regulation of calcium ion transmembrane transport", "negative regulation of calcium ion membrane transport", "downregulation of transmembrane calcium transport", "negative regulation of transmembrane calcium transport", "downregulation of calcium ion transmembrane transport", "downregulation of calcium ion membrane transport", "down-regulation of calcium ion membrane transport"], "types": ["T043"], "canonical_name": "negative regulation of calcium ion transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]"}
{"concept_id": "C3893983", "aliases": ["inhibition of calcium ion transmembrane transport", "inhibition of transmembrane calcium transport"], "types": ["T043"], "canonical_name": "inhibition of calcium ion membrane transport"}
{"concept_id": "C3893984", "aliases": [], "types": ["T038"], "canonical_name": "carbon dioxide homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of carbon dioxide within an organism or cell. [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594]"}
{"concept_id": "C3893985", "aliases": [], "types": ["T039"], "canonical_name": "cellular carbon dioxide homeostasis", "definition": "Any biological process involved in the maintenance of an internal steady state of carbon dioxide at the level of the cell. [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594]"}
{"concept_id": "C3893986", "aliases": ["fatty alcohol metabolism"], "types": ["T044"], "canonical_name": "fatty alcohol metabolic process", "definition": "The chemical reactions and pathways involving fatty alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493]"}
{"concept_id": "C3893987", "aliases": ["fatty alcohol breakdown", "fatty alcohol catabolism", "fatty alcohol degradation"], "types": ["T040"], "canonical_name": "fatty alcohol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of fatty alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493]"}
{"concept_id": "C3893988", "aliases": ["fatty alcohol synthesis", "fatty alcohol biosynthesis", "fatty alcohol formation", "fatty alcohol anabolism"], "types": ["T040"], "canonical_name": "fatty alcohol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fatty alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493]"}
{"concept_id": "C3893989", "aliases": ["regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "regulation of tyrosine 3-hydroxylase activity", "regulation of L-tyrosine hydroxylase activity", "regulation of tyrosine hydroxylase activity"], "types": ["T044"], "canonical_name": "regulation of tyrosine 3-monooxygenase activity", "definition": "Any process that modulates the frequency, rate or extent of tyrosine 3-monooxygenase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3893990", "aliases": ["inhibition of tyrosine 3-monooxygenase activity", "down regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "downregulation of tyrosine 3-hydroxylase activity", "down-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "negative regulation of tyrosine 3-hydroxylase activity", "downregulation of tyrosine hydroxylase activity", "negative regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "negative regulation of tyrosine hydroxylase activity", "inhibition of L-tyrosine hydroxylase activity", "down-regulation of tyrosine 3-hydroxylase activity", "down regulation of tyrosine hydroxylase activity", "inhibition of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "down regulation of tyrosine 3-hydroxylase activity", "down-regulation of L-tyrosine hydroxylase activity", "down regulation of tyrosine 3-monooxygenase activity", "downregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "negative regulation of L-tyrosine hydroxylase activity", "downregulation of L-tyrosine hydroxylase activity", "down-regulation of tyrosine hydroxylase activity", "inhibition of tyrosine 3-hydroxylase activity", "inhibition of tyrosine hydroxylase activity", "down regulation of L-tyrosine hydroxylase activity", "down-regulation of tyrosine 3-monooxygenase activity", "downregulation of tyrosine 3-monooxygenase activity"], "types": ["T044"], "canonical_name": "negative regulation of tyrosine 3-monooxygenase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tyrosine 3-monooxygenase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3893991", "aliases": ["up-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "stimulation of TH activity", "up-regulation of tyrosine 3-hydroxylase activity", "positive regulation of L-tyrosine hydroxylase activity", "positive regulation of tyrosine 3-hydroxylase activity", "positive regulation of tyrosine hydroxylase activity", "up regulation of L-tyrosine hydroxylase activity", "upregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "up-regulation of tyrosine 3-monooxygenase activity", "upregulation of L-tyrosine hydroxylase activity", "activation of L-tyrosine hydroxylase activity", "up regulation of tyrosine 3-monooxygenase activity", "activation of tyrosine 3-hydroxylase activity", "positive regulation of TH activity", "up regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "upregulation of tyrosine 3-hydroxylase activity", "activation of tyrosine hydroxylase activity", "upregulation of tyrosine 3-monooxygenase activity", "positive regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "activation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)", "up regulation of tyrosine hydroxylase activity", "activation of tyrosine 3-monooxygenase activity", "up regulation of tyrosine 3-hydroxylase activity", "up-regulation of tyrosine hydroxylase activity", "up-regulation of L-tyrosine hydroxylase activity", "upregulation of tyrosine hydroxylase activity"], "types": ["T044"], "canonical_name": "positive regulation of tyrosine 3-monooxygenase activity", "definition": "Any process that activates or increases the frequency, rate or extent of tyrosine 3-monooxygenase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]"}
{"concept_id": "C3893992", "aliases": ["regulation of dopamine biosynthesis", "regulation of dopamine anabolism", "regulation of dopamine formation", "regulation of dopamine synthesis"], "types": ["T044"], "canonical_name": "regulation of dopamine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of dopamine biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3893993", "aliases": ["inhibition of dopamine synthesis", "down regulation of dopamine biosynthetic process", "downregulation of dopamine anabolism", "negative regulation of dopamine synthesis", "downregulation of dopamine biosynthesis", "down-regulation of dopamine anabolism", "inhibition of dopamine anabolism", "down-regulation of dopamine biosynthetic process", "down-regulation of dopamine biosynthesis", "down regulation of dopamine formation", "down-regulation of dopamine formation", "down regulation of dopamine synthesis", "down regulation of dopamine biosynthesis", "inhibition of dopamine formation", "downregulation of dopamine synthesis", "negative regulation of dopamine biosynthesis", "negative regulation of dopamine formation", "downregulation of dopamine biosynthetic process", "inhibition of dopamine biosynthetic process", "downregulation of dopamine formation", "down-regulation of dopamine synthesis", "inhibition of dopamine biosynthesis", "negative regulation of dopamine anabolism", "down regulation of dopamine anabolism"], "types": ["T044"], "canonical_name": "negative regulation of dopamine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dopamine biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3893994", "aliases": ["positive regulation of dopamine biosynthesis", "activation of dopamine anabolism", "upregulation of dopamine biosynthetic process", "up-regulation of dopamine biosynthesis", "up regulation of dopamine synthesis", "upregulation of dopamine biosynthesis", "up regulation of dopamine biosynthetic process", "up regulation of dopamine biosynthesis", "positive regulation of dopamine formation", "upregulation of dopamine synthesis", "up-regulation of dopamine anabolism", "activation of dopamine synthesis", "up-regulation of dopamine synthesis", "activation of dopamine formation", "activation of dopamine biosynthetic process", "positive regulation of dopamine anabolism", "upregulation of dopamine anabolism", "up-regulation of dopamine biosynthetic process", "up regulation of dopamine anabolism", "up regulation of dopamine formation", "activation of dopamine biosynthesis", "positive regulation of dopamine synthesis", "upregulation of dopamine formation", "up-regulation of dopamine formation"], "types": ["T044"], "canonical_name": "positive regulation of dopamine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of dopamine biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]"}
{"concept_id": "C3893995", "aliases": ["regulation of SUMO conjugating enzyme activity", "regulation of SMT3 conjugating enzyme"], "types": ["T044"], "canonical_name": "regulation of SUMO transferase activity", "definition": "Any process that modulates the frequency, rate or extent of SUMO ligase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3893996", "aliases": ["down-regulation of SUMO conjugating enzyme activity", "inhibition of SUMO conjugating enzyme activity", "downregulation of SMT3 conjugating enzyme", "downregulation of SUMO conjugating enzyme activity", "down-regulation of SMT3 conjugating enzyme", "inhibition of SMT3 conjugating enzyme", "downregulation of SUMO ligase activity", "down regulation of SUMO ligase activity", "negative regulation of SMT3 conjugating enzyme", "down regulation of SUMO conjugating enzyme activity", "negative regulation of SUMO conjugating enzyme activity", "down regulation of SMT3 conjugating enzyme", "down-regulation of SUMO ligase activity"], "types": ["T044"], "canonical_name": "negative regulation of SUMO transferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528]"}
{"concept_id": "C3893997", "aliases": ["L-dopa metabolism"], "types": ["T044"], "canonical_name": "L-dopa metabolic process", "definition": "The chemical reactions and pathways involving L-dopa. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146]"}
{"concept_id": "C3893998", "aliases": ["L-dopa biosynthesis", "L-dopa synthesis", "L-dopa anabolism", "L-dopa formation"], "types": ["T044"], "canonical_name": "L-dopa biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-dopa. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146]"}
{"concept_id": "C3893999", "aliases": ["regulation of yolk production"], "types": ["T038"], "canonical_name": "regulation of vitellogenesis", "definition": "Any process that modulates the frequency, rate or extent of vitellogenesis. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235]"}
{"concept_id": "C3894000", "aliases": ["down-regulation of yolk production", "downregulation of yolk production", "inhibition of vitellogenesis", "downregulation of vitellogenesis", "inhibition of yolk production", "down regulation of vitellogenesis", "down regulation of yolk production", "down-regulation of vitellogenesis", "negative regulation of yolk production"], "types": ["T038"], "canonical_name": "negative regulation of vitellogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vitellogenesis. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235]"}
{"concept_id": "C3894001", "aliases": ["activation of yolk production", "upregulation of yolk production", "up regulation of yolk production", "up-regulation of yolk production", "up regulation of vitellogenesis", "upregulation of vitellogenesis", "up-regulation of vitellogenesis", "positive regulation of yolk production", "activation of vitellogenesis"], "types": ["T038"], "canonical_name": "positive regulation of vitellogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of vitellogenesis. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235]"}
{"concept_id": "C3894002", "aliases": ["glyoxal metabolism"], "types": ["T044"], "canonical_name": "glyoxal metabolic process", "definition": "The chemical reactions and pathways involving glyoxal. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894003", "aliases": ["glyoxal catabolism", "glyoxal degradation", "glyoxal breakdown"], "types": ["T044"], "canonical_name": "glyoxal catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of glyoxal. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22523093, PMID:23651081]"}
{"concept_id": "C3894004", "aliases": ["glyoxal biosynthesis", "glyoxal synthesis", "glyoxal formation", "glyoxal anabolism"], "types": ["T044"], "canonical_name": "glyoxal biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of glyoxal. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894005", "aliases": ["sesquarterpene metabolism"], "types": ["T044"], "canonical_name": "sesquarterpene metabolic process", "definition": "The chemical reactions and pathways involving sesquarterpene. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333]"}
{"concept_id": "C3894006", "aliases": ["sesquarterpene anabolism", "sesquarterpene biosynthesis", "sesquarterpene formation", "sesquarterpene synthesis"], "types": ["T044"], "canonical_name": "sesquarterpene biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of sesquarterpene. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333]"}
{"concept_id": "C3894007", "aliases": ["regulation of L-dopa anabolism", "regulation of L-dopa synthesis", "regulation of L-dopa formation", "regulation of L-dopa biosynthesis"], "types": ["T044"], "canonical_name": "regulation of L-dopa biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of L-dopa biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894008", "aliases": ["downregulation of L-dopa formation", "down regulation of L-dopa biosynthesis", "negative regulation of L-dopa synthesis", "inhibition of L-dopa anabolism", "down-regulation of L-dopa anabolism", "down-regulation of L-dopa formation", "downregulation of L-dopa synthesis", "down-regulation of L-dopa biosynthetic process", "down regulation of L-dopa synthesis", "down-regulation of L-dopa synthesis", "negative regulation of L-dopa formation", "negative regulation of L-dopa anabolism", "negative regulation of L-dopa biosynthesis", "downregulation of L-dopa biosynthesis", "downregulation of L-dopa anabolism", "inhibition of L-dopa biosynthesis", "down-regulation of L-dopa biosynthesis", "down regulation of L-dopa anabolism", "down regulation of L-dopa biosynthetic process", "down regulation of L-dopa formation", "downregulation of L-dopa biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of L-dopa biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894009", "aliases": ["inhibition of L-dopa synthesis", "inhibition of L-dopa formation"], "types": ["T044"], "canonical_name": "inhibition of L-dopa biosynthetic process"}
{"concept_id": "C3894010", "aliases": ["up-regulation of L-dopa anabolism", "activation of L-dopa biosynthesis", "up-regulation of L-dopa biosynthetic process", "activation of L-dopa formation", "up regulation of L-dopa synthesis", "activation of L-dopa biosynthetic process", "upregulation of L-dopa biosynthetic process", "positive regulation of L-dopa anabolism", "positive regulation of L-dopa formation", "up-regulation of L-dopa biosynthesis", "upregulation of L-dopa synthesis", "activation of L-dopa anabolism", "up regulation of L-dopa formation", "positive regulation of L-dopa biosynthesis", "up regulation of L-dopa anabolism", "up regulation of L-dopa biosynthetic process", "activation of L-dopa synthesis", "upregulation of L-dopa formation", "up regulation of L-dopa biosynthesis", "up-regulation of L-dopa synthesis", "positive regulation of L-dopa synthesis", "upregulation of L-dopa biosynthesis", "upregulation of L-dopa anabolism", "up-regulation of L-dopa formation"], "types": ["T044"], "canonical_name": "positive regulation of L-dopa biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of L-dopa biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528]"}
{"concept_id": "C3894011", "aliases": ["regulation of DOPA decarboxylase activity", "regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "regulation of DDC activity"], "types": ["T044"], "canonical_name": "regulation of L-dopa decarboxylase activity", "definition": "Any process that modulates the frequency, rate or extent of L-dopa decarboxylase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894012", "aliases": ["down regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "negative regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "down-regulation of DDC activity", "down-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "downregulation of DDC activity", "down-regulation of L-dopa decarboxylase activity", "inhibition of DDC activity", "negative regulation of DDC activity", "inhibition of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "down regulation of DDC activity", "down regulation of L-dopa decarboxylase activity", "downregulation of L-dopa decarboxylase activity", "downregulation of DOPA decarboxylase activity", "inhibition of L-dopa decarboxylase activity", "inhibition of DOPA decarboxylase activity", "down-regulation of DOPA decarboxylase activity", "downregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "negative regulation of DOPA decarboxylase activity", "down regulation of DOPA decarboxylase activity"], "types": ["T044"], "canonical_name": "negative regulation of L-dopa decarboxylase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa decarboxylase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894013", "aliases": ["up regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "positive regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "upregulation of DDC activity", "positive regulation of DDC activity", "up-regulation of DDC activity", "up-regulation of L-dopa decarboxylase activity", "up regulation of L-dopa decarboxylase activity", "positive regulation of DOPA decarboxylase activity", "up-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "up regulation of DDC activity", "upregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity", "up regulation of DOPA decarboxylase activity", "upregulation of DOPA decarboxylase activity", "upregulation of L-dopa decarboxylase activity", "up-regulation of DOPA decarboxylase activity"], "types": ["T044"], "canonical_name": "positive regulation of L-dopa decarboxylase activity", "definition": "Any process that activates or increases the frequency, rate or extent of L-dopa decarboxylase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]"}
{"concept_id": "C3894014", "aliases": ["activation of L-dopa decarboxylase activity", "activation of DDC activity", "activation of DOPA decarboxylase activity"], "types": ["T044"], "canonical_name": "activation of 4-dihydroxyl-L-phenylalanine decarboxylase activity"}
{"concept_id": "C3894015", "aliases": ["regulation of cell death in response to oxidative stress"], "types": ["T043"], "canonical_name": "regulation of oxidative stress-induced cell death", "definition": "Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894016", "aliases": ["downregulation of cell death in response to oxidative stress", "protection against oxidative stress-induced cell death", "down-regulation of cell death in response to oxidative stress", "negative regulation of cell death in response to oxidative stress", "inhibition of cell death in response to oxidative stress", "down regulation of cell death in response to oxidative stress"], "types": ["T043"], "canonical_name": "negative regulation of oxidative stress-induced cell death", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]"}
{"concept_id": "C3894017", "aliases": ["regulation of neuronal cell death in response to oxidative stress", "regulation of neuron death in response to oxidative stress"], "types": ["T043"], "canonical_name": "regulation of oxidative stress-induced neuron death", "definition": "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894018", "aliases": ["inhibition of oxidative stress-induced neuron death", "downregulation of neuronal cell death in response to oxidative stress", "downregulation of neuron death in response to oxidative stress", "neuronal protection under oxidative stress", "down regulation of neuronal cell death in response to oxidative stress", "inhibition of neuron death in response to oxidative stress", "down-regulation of neuronal cell death in response to oxidative stress", "negative regulation of neuronal cell death in response to oxidative stress", "down-regulation of oxidative stress-induced neuron death", "inhibition of neuronal cell death in response to oxidative stress", "down regulation of oxidative stress-induced neuron death", "down regulation of neuron death in response to oxidative stress", "down-regulation of neuron death in response to oxidative stress", "neuroprotection against oxidative stress", "downregulation of oxidative stress-induced neuron death"], "types": ["T043"], "canonical_name": "negative regulation of oxidative stress-induced neuron death", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]"}
{"concept_id": "C3894019", "aliases": ["regulation of hydrogen peroxide-mediated cell death", "regulation of cell death in response to H2O2", "protection against hydrogen peroxide-mediated cell death", "regulation of cell death in response to hydrogen peroxide"], "types": ["T043"], "canonical_name": "regulation of hydrogen peroxide-induced cell death", "definition": "Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894020", "aliases": ["downregulation of hydrogen peroxide-mediated cell death", "negative regulation of hydrogen peroxide-mediated cell death", "downregulation of cell death in response to hydrogen peroxide", "inhibition of cell death in response to hydrogen peroxide", "protection against hydrogen peroxide-induced cell death", "inhibition of cell death in response to H2O2", "downregulation of cell death in response to H2O2", "down-regulation of cell death in response to H2O2", "inhibition of hydrogen peroxide-mediated cell death", "negative regulation of cell death in response to hydrogen peroxide", "negative regulation of cell death in response to H2O2", "down regulation of cell death in response to H2O2", "down regulation of cell death in response to hydrogen peroxide", "down-regulation of cell death in response to hydrogen peroxide", "protection against H2O2-induced cell death"], "types": ["T043"], "canonical_name": "negative regulation of hydrogen peroxide-induced cell death", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14749723, PMID:24252804]"}
{"concept_id": "C3894021", "aliases": ["down-regulation of hydrogen peroxide-mediated cell death"], "types": ["T043"], "canonical_name": "down regulation of hydrogen peroxide-mediated cell death"}
{"concept_id": "C3894022", "aliases": ["regulation of neuron death in response to H2O2", "regulation of neuronal cell death in response to hydrogen peroxide", "regulation of neuron death in response to hydrogen peroxide"], "types": ["T043"], "canonical_name": "regulation of hydrogen peroxide-induced neuron death", "definition": "Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced neuron death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894023", "aliases": ["down regulation of neuronal cell death in response to hydrogen peroxide", "downregulation of neuron death in response to hydrogen peroxide", "down-regulation of neuron death in response to H2O2", "inhibition of neuron death in response to hydrogen peroxide", "downregulation of hydrogen peroxide-induced neuron death", "downregulation of neuron death in response to H2O2", "negative regulation of neuron death in response to hydrogen peroxide", "down regulation of neuron death in response to H2O2", "inhibition of neuronal cell death in response to hydrogen peroxide", "neuroprotection against hydrogen peroxide", "downregulation of neuronal cell death in response to hydrogen peroxide", "down regulation of hydrogen peroxide-induced neuron death", "down-regulation of neuronal cell death in response to hydrogen peroxide", "down regulation of neuron death in response to hydrogen peroxide", "protection against H2O2-induced neuron death", "negative regulation of neuron death in response to H2O2", "negative regulation of neuronal cell death in response to hydrogen peroxide", "inhibition of neuron death in response to H2O2", "neuroprotection against H2O2-induced cell death", "down-regulation of neuron death in response to hydrogen peroxide", "protection against hydrogen peroxide-induced neuron death", "inhibition of hydrogen peroxide-induced neuron death", "down-regulation of hydrogen peroxide-induced neuron death"], "types": ["T043"], "canonical_name": "negative regulation of hydrogen peroxide-induced neuron death", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced neuron death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]"}
{"concept_id": "C3894024", "aliases": ["glomerular podocyte apoptotic process", "up-regulation of cell death in response to oxidative stress", "activation of cell death in response to oxidative stress", "glomerular visceral epithelial cell apoptotic process", "podocyte apoptosis", "enhancement of oxidative stress-induced cell death", "glomerular visceral epithelial cell apoptosis", "glomerular podocyte apoptosis", "upregulation of cell death in response to oxidative stress", "positive regulation of oxidative stress-induced cell death", "up regulation of cell death in response to oxidative stress", "positive regulation of cell death in response to oxidative stress"], "types": ["T043"], "canonical_name": "podocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:20969476]"}
{"concept_id": "C3894026", "aliases": ["protein localisation to mating-type region heterochromatin", "protein localisation in mating-type region heterochromatin", "protein localization in mating-type region heterochromatin"], "types": ["T045"], "canonical_name": "protein localization to mating-type region heterochromatin", "definition": "A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin. [GO_REF:0000087, GOC:TermGenie, PMID:18761674]"}
{"concept_id": "C3894027", "aliases": ["protein localisation to subtelomeric heterochromatin", "protein localization in subtelomeric heterochromatin", "protein localisation in subtelomeric heterochromatin"], "types": ["T045"], "canonical_name": "protein localization to subtelomeric heterochromatin", "definition": "A process in which a protein is transported to, or maintained in, a location within a subtelomeric heterochromatin. [GO_REF:0000087, GOC:TermGenie, PMID:21300781, SO:0001997]"}
{"concept_id": "C3894028", "aliases": ["regulation of protein targeting to mitochondria", "regulation of protein-mitochondrial targeting", "regulation of protein import into mitochondrion"], "types": ["T043"], "canonical_name": "regulation of protein targeting to mitochondrion", "definition": "Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894029", "aliases": ["regulation of mitochondrial translocation"], "types": ["T043"], "canonical_name": "regulation of mitochondrial protein import"}
{"concept_id": "C3894030", "aliases": ["down regulation of protein-mitochondrial targeting", "downregulation of protein import into mitochondrion", "down-regulation of protein-mitochondrial targeting", "downregulation of protein targeting to mitochondria", "down-regulation of protein targeting to mitochondria", "negative regulation of protein targeting to mitochondria", "down-regulation of protein import into mitochondrion", "downregulation of protein targeting to mitochondrion", "inhibition of protein targeting to mitochondrion", "down regulation of protein import into mitochondrion", "downregulation of protein-mitochondrial targeting", "inhibition of protein targeting to mitochondria", "negative regulation of protein import into mitochondrion", "down-regulation of protein targeting to mitochondrion", "down regulation of protein targeting to mitochondrion", "down regulation of protein targeting to mitochondria", "negative regulation of protein-mitochondrial targeting"], "types": ["T043"], "canonical_name": "negative regulation of protein targeting to mitochondrion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]"}
{"concept_id": "C3894031", "aliases": ["negative regulation of mitochondrial translocation", "negative regulation of mitochondrial protein import", "inhibition of protein import into mitochondrion", "inhibition of protein-mitochondrial targeting", "downregulation of mitochondrial protein import", "down-regulation of mitochondrial translocation", "downregulation of mitochondrial translocation", "down-regulation of mitochondrial protein import", "inhibition of mitochondrial protein import", "down regulation of mitochondrial translocation", "inhibition of mitochondrial translocation"], "types": ["T043"], "canonical_name": "down regulation of mitochondrial protein import"}
{"concept_id": "C3894032", "aliases": ["regulation of mitochondrial protein processing during import", "regulation of mitochondrial processing"], "types": ["T043"], "canonical_name": "regulation of protein processing involved in protein targeting to mitochondrion", "definition": "Any process that modulates the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]"}
{"concept_id": "C3894033", "aliases": ["down-regulation of protein processing involved in protein targeting to mitochondrion", "inhibition of mitochondrial protein processing during import", "down-regulation of mitochondrial protein processing during import", "down regulation of mitochondrial protein processing during import", "downregulation of protein processing involved in protein targeting to mitochondrion", "inhibition of protein processing involved in protein targeting to mitochondrion", "downregulation of mitochondrial protein processing during import", "negative regulation of mitochondrial protein processing during import", "down regulation of protein processing involved in protein targeting to mitochondrion"], "types": ["T045"], "canonical_name": "negative regulation of protein processing involved in protein targeting to mitochondrion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]"}
{"concept_id": "C3894034", "aliases": ["regulation of L-malate:NADP oxidoreductase activity", "regulation of NADP-linked decarboxylating malic enzyme", "regulation of malate dehydrogenase (NADP, decarboxylating)", "regulation of NADP-malic enzyme activity", "regulation of 'malic' enzyme", "regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "regulation of NADP-specific malate dehydrogenase activity", "regulation of malate dehydrogenase (decarboxylating, NADP)", "regulation of NADP-specific malic enzyme"], "types": ["T044"], "canonical_name": "regulation of malate dehydrogenase (decarboxylating) (NADP+) activity", "definition": "Any process that modulates the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity. [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416]"}
{"concept_id": "C3894035", "aliases": ["down-regulation of NADP-malic enzyme activity", "down regulation of 'malic' enzyme", "down-regulation of L-malate:NADP oxidoreductase activity", "down-regulation of NADP-specific malate dehydrogenase activity", "down regulation of NADP-malic enzyme activity", "negative regulation of malate dehydrogenase (NADP, decarboxylating)", "downregulation of NADP-malic enzyme activity", "downregulation of malate dehydrogenase (decarboxylating, NADP)", "down-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity", "downregulation of L-malate:NADP oxidoreductase activity", "down regulation of malate dehydrogenase (NADP, decarboxylating)", "down-regulation of malate dehydrogenase (decarboxylating, NADP)", "down-regulation of 'malic' enzyme", "down regulation of L-malate:NADP oxidoreductase activity", "downregulation of NADP-linked decarboxylating malic enzyme", "down regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "negative regulation of L-malate:NADP oxidoreductase activity", "negative regulation of NADP-malic enzyme activity", "downregulation of malate dehydrogenase (NADP, decarboxylating)", "down regulation of NADP-specific malate dehydrogenase activity", "downregulation of NADP-specific malate dehydrogenase activity", "down-regulation of malate dehydrogenase (NADP, decarboxylating)", "downregulation of malate dehydrogenase (decarboxylating) (NADP+) activity", "down-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "negative regulation of malate dehydrogenase (decarboxylating, NADP)", "downregulation of NADP-specific malic enzyme", "downregulation of 'malic' enzyme", "negative regulation of NADP-specific malate dehydrogenase activity", "inhibition of 'malic' enzyme", "negative regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "down regulation of malate dehydrogenase (decarboxylating) (NADP+) activity", "down regulation of malate dehydrogenase (decarboxylating, NADP)", "downregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)"], "types": ["T044"], "canonical_name": "negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity. [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416]"}
{"concept_id": "C3894036", "aliases": ["down-regulation of NADP-linked decarboxylating malic enzyme"], "types": ["T044"], "canonical_name": "down regulation of NADP-linked decarboxylating malic enzyme"}
{"concept_id": "C3894037", "aliases": ["down-regulation of NADP-specific malic enzyme"], "types": ["T044"], "canonical_name": "down regulation of NADP-specific malic enzyme"}
{"concept_id": "C3894038", "aliases": ["negative regulation of NADP-specific malic enzyme", "inhibition of L-malate:NADP oxidoreductase activity", "inhibition of NADP-linked decarboxylating malic enzyme", "inhibition of NADP-specific malic enzyme", "negative regulation of NADP-linked decarboxylating malic enzyme", "inhibition of malate dehydrogenase (decarboxylating) (NADP+) activity", "inhibition of NADP-malic enzyme activity", "negative regulation of 'malic' enzyme", "inhibition of NADP-specific malate dehydrogenase activity"], "types": ["T044"], "canonical_name": "inhibition of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)"}
{"concept_id": "C3894039", "aliases": ["inhibition of malate dehydrogenase (decarboxylating, NADP)"], "types": ["T044"], "canonical_name": "inhibition of malate dehydrogenase (NADP, decarboxylating)"}
{"concept_id": "C3894040", "aliases": ["upregulation of NADP-specific malate dehydrogenase activity", "upregulation of malate dehydrogenase (decarboxylating) (NADP+) activity", "up regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "upregulation of NADP-malic enzyme activity", "upregulation of malate dehydrogenase (decarboxylating, NADP)", "up-regulation of malate dehydrogenase (decarboxylating, NADP)", "up regulation of malate dehydrogenase (decarboxylating, NADP)", "positive regulation of malate dehydrogenase (decarboxylating, NADP)", "upregulation of malate dehydrogenase (NADP, decarboxylating)", "up-regulation of 'malic' enzyme", "upregulation of 'malic' enzyme", "up-regulation of NADP-malic enzyme activity", "positive regulation of NADP-specific malic enzyme", "positive regulation of NADP-linked decarboxylating malic enzyme", "activation of NADP-specific malic enzyme", "activation of malate dehydrogenase (decarboxylating) (NADP+) activity", "positive regulation of NADP-specific malate dehydrogenase activity", "up regulation of NADP-specific malate dehydrogenase activity", "up-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "upregulation of L-malate:NADP oxidoreductase activity", "up regulation of NADP-malic enzyme activity", "up regulation of L-malate:NADP oxidoreductase activity", "up-regulation of malate dehydrogenase (NADP, decarboxylating)", "positive regulation of 'malic' enzyme", "up-regulation of NADP-specific malate dehydrogenase activity", "positive regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "activation of NADP-malic enzyme activity", "up regulation of malate dehydrogenase (decarboxylating) (NADP+) activity", "activation of 'malic' enzyme", "upregulation of NADP-linked decarboxylating malic enzyme", "activation of NADP-linked decarboxylating malic enzyme", "activation of L-malate:NADP oxidoreductase activity", "positive regulation of malate dehydrogenase (NADP, decarboxylating)", "upregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "up regulation of 'malic' enzyme", "activation of NADP-specific malate dehydrogenase activity", "up-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity", "up-regulation of L-malate:NADP oxidoreductase activity", "up regulation of malate dehydrogenase (NADP, decarboxylating)", "upregulation of NADP-specific malic enzyme", "positive regulation of L-malate:NADP oxidoreductase activity", "activation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)", "positive regulation of NADP-malic enzyme activity"], "types": ["T044"], "canonical_name": "positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity", "definition": "Any process that activates or increases the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity. [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416]"}
{"concept_id": "C3894041", "aliases": ["activation of malate dehydrogenase (decarboxylating, NADP)"], "types": ["T044"], "canonical_name": "activation of malate dehydrogenase (NADP, decarboxylating)"}
{"concept_id": "C3894042", "aliases": ["up-regulation of NADP-linked decarboxylating malic enzyme"], "types": ["T044"], "canonical_name": "up regulation of NADP-linked decarboxylating malic enzyme"}
{"concept_id": "C3894043", "aliases": ["up-regulation of NADP-specific malic enzyme"], "types": ["T044"], "canonical_name": "up regulation of NADP-specific malic enzyme"}
{"concept_id": "C3894044", "aliases": ["regulation of mitotic recombination involved in replication fork restart", "prevention of genomic instability induced by DNA replication fork arrest", "regulation of mitotic recombination involved in replication restart", "regulation of mitotic recombination involved in recovery from replication fork arrest", "regulation of mitotic recombination involved in collapsed replication fork processing", "regulation of mitotic recombination involved in replication fork processing", "regulation of mitotic recombination involved in recovery from replication fork stalling"], "types": ["T043"], "canonical_name": "regulation of mitotic recombination-dependent replication fork processing", "definition": "Any process that modulates the frequency, rate or extent of mitotic recombination-dependent replication fork processing. Regulation of mitotic recombination prevents recombination between inappropriate homologous sequences. [GO_REF:0000058, GOC:TermGenie, PMID:23093942]"}
{"concept_id": "C3894045", "aliases": [], "types": ["T043"], "canonical_name": "quinolinic acid transmembrane transport", "definition": "The process in which quinolinic acid is transported across a membrane. [GO_REF:0000069, GOC:di, GOC:TermGenie, PMID:23457190]"}
{"concept_id": "C3894046", "aliases": ["upregulation of neuronal cell death in response to oxidative stress", "up regulation of neuron death in response to oxidative stress", "up regulation of neuronal cell death in response to oxidative stress", "upregulation of neuron death in response to oxidative stress", "activation of oxidative stress-induced neuron death", "up regulation of oxidative stress-induced neuron death", "activation of neuron death in response to oxidative stress", "activation of neuronal cell death in response to oxidative stress", "sensitization of neuron to oxidative stress-induced cell death", "up-regulation of oxidative stress-induced neuron death", "upregulation of oxidative stress-induced neuron death", "up-regulation of neuron death in response to oxidative stress", "positive regulation of neuron death in response to oxidative stress", "positive regulation of neuronal cell death in response to oxidative stress", "up-regulation of neuronal cell death in response to oxidative stress"], "types": ["T043"], "canonical_name": "positive regulation of oxidative stress-induced neuron death", "definition": "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23858059]"}
{"concept_id": "C3894047", "aliases": ["regulation of endoderm cell differentiation"], "types": ["T039"], "canonical_name": "regulation of endodermal cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of endodermal cell differentiation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]"}
{"concept_id": "C3894048", "aliases": ["down-regulation of endodermal cell differentiation", "downregulation of endoderm cell differentiation", "negative regulation of endoderm cell differentiation", "downregulation of endodermal cell differentiation", "inhibition of endodermal cell differentiation", "down regulation of endodermal cell differentiation", "down regulation of endoderm cell differentiation", "inhibition of endoderm cell differentiation", "down-regulation of endoderm cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of endodermal cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]"}
{"concept_id": "C3894049", "aliases": ["up-regulation of endoderm cell differentiation", "activation of endoderm cell differentiation", "up regulation of endodermal cell differentiation", "upregulation of endodermal cell differentiation", "up-regulation of endodermal cell differentiation", "positive regulation of endoderm cell differentiation", "up regulation of endoderm cell differentiation", "upregulation of endoderm cell differentiation", "activation of endodermal cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of endodermal cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]"}
{"concept_id": "C3894050", "aliases": ["xanthosine metabolism"], "types": ["T044"], "canonical_name": "xanthosine metabolic process", "definition": "The chemical reactions and pathways involving xanthosine. [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336]"}
{"concept_id": "C3894051", "aliases": ["xanthosine breakdown", "xanthosine degradation", "xanthosine catabolism"], "types": ["T044"], "canonical_name": "xanthosine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of xanthosine. [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336]"}
{"concept_id": "C3894052", "aliases": ["xanthosine anabolism", "xanthosine synthesis", "xanthosine formation", "xanthosine biosynthesis"], "types": ["T044"], "canonical_name": "xanthosine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of xanthosine. [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336]"}
{"concept_id": "C3894054", "aliases": ["mRNA base-pairing posttranscriptional repressor activity", "mRNA binding involved in cosuppression", "mRNA binding involved in PTGS", "mRNA binding involved in post-transcriptional gene silencing", "mRNA binding involved in posttranscriptional gene silencing", "mRNA binding involved in quelling"], "types": ["T045"], "canonical_name": "mRNA base-pairing post-transcriptional repressor activity", "definition": "A translation repressor activity that acts by base-pairing with an mRNA. The binding can result in targeting the mRNA for degradation or interfering with mRNA translation, hence resulting in posttranscriptional gene silencing. [GOC:BHF, GOC:BHF_miRNA, PMID:18197166, PMID:20533884]"}
{"concept_id": "C3894055", "aliases": ["melanosome formation"], "types": ["T043"], "canonical_name": "melanosome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22511774]"}
{"concept_id": "C3894056", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium ion-dependent exocytosis of neurotransmitter", "definition": "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter. [GO_REF:0000058, GOC:TermGenie, PMID:16782817]"}
{"concept_id": "C3894057", "aliases": ["downregulation of calcium ion-dependent exocytosis of neurotransmitter", "inhibition of calcium ion-dependent exocytosis of neurotransmitter", "down-regulation of calcium ion-dependent exocytosis of neurotransmitter", "down regulation of calcium ion-dependent exocytosis of neurotransmitter"], "types": ["T043"], "canonical_name": "negative regulation of calcium ion-dependent exocytosis of neurotransmitter", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter. [GO_REF:0000058, GOC:TermGenie, PMID:16782817]"}
{"concept_id": "C3894058", "aliases": ["up regulation of calcium ion-dependent exocytosis of neurotransmitter", "up-regulation of calcium ion-dependent exocytosis of neurotransmitter", "activation of calcium ion-dependent exocytosis of neurotransmitter", "upregulation of calcium ion-dependent exocytosis of neurotransmitter"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion-dependent exocytosis of neurotransmitter", "definition": "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter. [GO_REF:0000058, GOC:TermGenie, PMID:16782817]"}
{"concept_id": "C3894059", "aliases": [], "types": ["T043"], "canonical_name": "regulation of leukocyte tethering or rolling", "definition": "Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]"}
{"concept_id": "C3894060", "aliases": ["down regulation of leukocyte tethering or rolling", "downregulation of leukocyte tethering or rolling", "inhibition of leukocyte tethering or rolling", "down-regulation of leukocyte tethering or rolling"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte tethering or rolling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]"}
{"concept_id": "C3894061", "aliases": ["upregulation of leukocyte tethering or rolling", "up regulation of leukocyte tethering or rolling", "up-regulation of leukocyte tethering or rolling", "activation of leukocyte tethering or rolling"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte tethering or rolling", "definition": "Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]"}
{"concept_id": "C3894064", "aliases": ["major prespliceosome assembly", "major prespliceosome formation", "GT-AG prespliceosome formation", "GT-AG prespliceosome assembly", "U2-type prespliceosome formation"], "types": ["T045"], "canonical_name": "U2-type prespliceosome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome. [GO_REF:0000079, GOC:TermGenie, PMID:12374752]"}
{"concept_id": "C3894065", "aliases": [], "types": ["T045"], "canonical_name": "mammalian U2-type spliceosomal complex A assembly"}
{"concept_id": "C3894066", "aliases": [], "types": ["T045"], "canonical_name": "mammalian U2-type spliceosomal complex A formation"}
{"concept_id": "C3894067", "aliases": [], "types": ["T045"], "canonical_name": "yeast U2-type spliceosomal complex B assembly"}
{"concept_id": "C3894068", "aliases": [], "types": ["T045"], "canonical_name": "yeast U2-type spliceosomal complex B formation"}
{"concept_id": "C3894069", "aliases": [], "types": ["T039"], "canonical_name": "regulation of cardiac muscle hypertrophy in response to stress", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]"}
{"concept_id": "C3894070", "aliases": ["down-regulation of cardiac muscle hypertrophy in response to stress", "down regulation of cardiac muscle hypertrophy in response to stress", "downregulation of cardiac muscle hypertrophy in response to stress"], "types": ["T039"], "canonical_name": "negative regulation of cardiac muscle hypertrophy in response to stress", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]"}
{"concept_id": "C3894071", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cardiac muscle hypertrophy in response to stress"}
{"concept_id": "C3894072", "aliases": ["up-regulation of cardiac muscle hypertrophy in response to stress", "up regulation of cardiac muscle hypertrophy in response to stress", "upregulation of cardiac muscle hypertrophy in response to stress"], "types": ["T039"], "canonical_name": "positive regulation of cardiac muscle hypertrophy in response to stress", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]"}
{"concept_id": "C3894073", "aliases": [], "types": ["T039"], "canonical_name": "activation of cardiac muscle hypertrophy in response to stress"}
{"concept_id": "C3894088", "aliases": ["regulation of citrulline formation", "regulation of citrulline synthesis", "regulation of citrulline biosynthesis", "regulation of citrulline anabolism"], "types": ["T044"], "canonical_name": "regulation of citrulline biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of citrulline biosynthetic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978]"}
{"concept_id": "C3894089", "aliases": ["down regulation of citrulline synthesis", "negative regulation of citrulline anabolism", "down-regulation of citrulline anabolism", "downregulation of citrulline synthesis", "down regulation of citrulline biosynthesis", "down-regulation of citrulline biosynthetic process", "inhibition of citrulline formation", "down-regulation of citrulline synthesis", "inhibition of citrulline anabolism", "downregulation of citrulline anabolism", "negative regulation of citrulline formation", "inhibition of citrulline biosynthetic process", "down regulation of citrulline biosynthetic process", "inhibition of citrulline biosynthesis", "downregulation of citrulline biosynthetic process", "down regulation of citrulline formation", "negative regulation of citrulline biosynthesis", "downregulation of citrulline formation", "down-regulation of citrulline biosynthesis", "downregulation of citrulline biosynthesis", "down regulation of citrulline anabolism", "negative regulation of citrulline synthesis", "inhibition of citrulline synthesis", "down-regulation of citrulline formation"], "types": ["T044"], "canonical_name": "negative regulation of citrulline biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of citrulline biosynthetic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978]"}
{"concept_id": "C3894090", "aliases": ["up-regulation of citrulline biosynthetic process", "activation of citrulline biosynthetic process", "up regulation of citrulline synthesis", "activation of citrulline formation", "activation of citrulline biosynthesis", "upregulation of citrulline anabolism", "upregulation of citrulline formation", "upregulation of citrulline synthesis", "up regulation of citrulline anabolism", "positive regulation of citrulline synthesis", "positive regulation of citrulline anabolism", "up-regulation of citrulline synthesis", "up-regulation of citrulline formation", "up-regulation of citrulline anabolism", "up regulation of citrulline biosynthetic process", "activation of citrulline anabolism", "positive regulation of citrulline formation", "upregulation of citrulline biosynthetic process", "activation of citrulline synthesis", "positive regulation of citrulline biosynthesis", "up-regulation of citrulline biosynthesis", "up regulation of citrulline biosynthesis", "upregulation of citrulline biosynthesis", "up regulation of citrulline formation"], "types": ["T044"], "canonical_name": "positive regulation of citrulline biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of citrulline biosynthetic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978]"}
{"concept_id": "C3894091", "aliases": [], "types": ["T043"], "canonical_name": "multiciliate cell differentiation", "definition": "OBSOLETE. The process in which a relatively unspecialized cell acquires features of a multiciliated cell, a specialized epithelial cell type that extends anywhere from 150 to 200 motile cilia per cell in order to produce a vigorous fluid flow critical to human health in several organ systems. [PMID:22231168, PMID:24934224]"}
{"concept_id": "C3894092", "aliases": ["hercynylcysteine sulfoxide metabolism"], "types": ["T044"], "canonical_name": "hercynylcysteine sulfoxide metabolic process", "definition": "The chemical reactions and pathways involving hercynylcysteine sulfoxide. [GO_REF:0000068, GOC:TermGenie, PMID:24828577]"}
{"concept_id": "C3894093", "aliases": ["hercynylcysteine sulfoxide formation", "hercynylcysteine sulfoxide anabolism", "hercynylcysteine sulfoxide synthesis", "hercynylcysteine sulfoxide biosynthesis"], "types": ["T044"], "canonical_name": "hercynylcysteine sulfoxide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hercynylcysteine sulfoxide. [GO_REF:0000068, GOC:TermGenie, PMID:24828577]"}
{"concept_id": "C3894094", "aliases": ["hercynylselenocysteine metabolism"], "types": ["T044"], "canonical_name": "hercynylselenocysteine metabolic process", "definition": "The chemical reactions and pathways involving hercynylselenocysteine. [GO_REF:0000068, GOC:TermGenie, PMID:24828577]"}
{"concept_id": "C3894095", "aliases": ["hercynylselenocysteine synthesis", "hercynylselenocysteine anabolism", "hercynylselenocysteine biosynthesis", "hercynylselenocysteine formation"], "types": ["T044"], "canonical_name": "hercynylselenocysteine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of hercynylselenocysteine. [GO_REF:0000068, GOC:TermGenie, PMID:24828577]"}
{"concept_id": "C3894096", "aliases": ["L-selenoneine metabolic process", "selenoneine metabolism"], "types": ["T044"], "canonical_name": "selenoneine metabolic process", "definition": "The chemical reactions and pathways involving selenoneine. [GO_REF:0000068, GOC:TermGenie, PMID:24828577]"}
{"concept_id": "C3894097", "aliases": ["L-selenoneine biosynthetic process", "selenoneine synthesis", "selenoneine formation", "selenoneine biosynthesis", "selenoneine anabolism"], "types": ["T044"], "canonical_name": "selenoneine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of selenoneine. [GO_REF:0000068, GOC:TermGenie, PMID:24828577]"}
{"concept_id": "C3894098", "aliases": ["sorbose import into cell"], "types": ["T043"], "canonical_name": "sorbose import across plasma membrane", "definition": "The process in which sorbose is transported from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:2878925]"}
{"concept_id": "C3894099", "aliases": ["EJC disassembly"], "types": ["T044"], "canonical_name": "exon-exon junction complex disassembly", "definition": "The disaggregation of an exon-exon junction complex into its constituent components. [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:24967911]"}
{"concept_id": "C3894100", "aliases": ["protein localization in mating projection tip", "protein localisation to mating projection tip", "protein localization to shmoo tip", "protein localisation in mating projection tip", "protein localization to conjugation tube tip"], "types": ["T043"], "canonical_name": "protein localization to mating projection tip", "definition": "A process in which a protein is transported to, or maintained in, a location within a mating projection tip. [GO_REF:0000087, GOC:TermGenie, PMID:11952834]"}
{"concept_id": "C3894101", "aliases": [], "types": ["T044"], "canonical_name": "regulation of serine phosphorylation of STAT3 protein"}
{"concept_id": "C3894104", "aliases": ["respiratory nitrate reductase activity involved in anaerobic electron transport chain", "nitrite:(acceptor) oxidoreductase involved in anaerobic electron transport chain", "nitrite:acceptor oxidoreductase involved in anaerobic electron transport chain", "nitrate reductase (acceptor) involved in anaerobic electron transport chain"], "types": ["T044"], "canonical_name": "nitrate reductase activity involved in anaerobic electron transport chain", "definition": "Any nitrate reductase activity that is involved in anaerobic electron transport chain. [GO_REF:0000061, GOC:dos, GOC:TermGenie, PMID:12910261]"}
{"concept_id": "C3894105", "aliases": ["activation of tumor necrosis factor-mediated signaling pathway", "upregulation of tumor necrosis factor-mediated signalling pathway", "up-regulation of tumor necrosis factor-mediated signalling pathway", "positive regulation of tumor necrosis factor-mediated signalling pathway", "up regulation of tumor necrosis factor alpha-mediated signaling pathway", "upregulation of tumor necrosis factor-mediated signaling pathway", "up regulation of tumor necrosis factor-mediated signalling pathway", "up-regulation of tumor necrosis factor alpha-mediated signaling pathway", "up regulation of tumor necrosis factor-mediated signaling pathway", "activation of tumor necrosis factor-mediated signalling pathway", "up-regulation of tumor necrosis factor-mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of tumor necrosis factor-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807]"}
{"concept_id": "C3894106", "aliases": ["activation of tumor necrosis factor alpha-mediated signaling pathway", "positive regulation of tumor necrosis factor alpha-mediated signaling pathway", "upregulation of tumor necrosis factor alpha-mediated signaling pathway", "positive regulation of TNF-alpha-mediated signaling pathway", "positive regulation of adipocytokine signaling pathway", "upregulation of adipocytokine signaling pathway", "activation of adipocytokine signaling pathway", "up regulation of adipocytokine signaling pathway", "upregulation of TNF-alpha-mediated signaling pathway", "up-regulation of adipocytokine signaling pathway"], "types": ["T044"], "canonical_name": "activation of TNF-alpha-mediated signaling pathway"}
{"concept_id": "C3894107", "aliases": ["up-regulation of TNF-alpha-mediated signaling pathway"], "types": ["T044"], "canonical_name": "up regulation of TNF-alpha-mediated signaling pathway"}
{"concept_id": "C3894108", "aliases": ["regulation of ornithine degradation", "regulation of ornithine catabolism", "regulation of ornithine breakdown"], "types": ["T044"], "canonical_name": "regulation of ornithine catabolic process", "definition": "Any process that modulates the frequency, rate or extent of ornithine catabolic process. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340]"}
{"concept_id": "C3894109", "aliases": ["downregulation of ornithine catabolism", "inhibition of ornithine breakdown", "down-regulation of ornithine degradation", "down-regulation of ornithine catabolism", "downregulation of ornithine degradation", "down-regulation of ornithine breakdown", "negative regulation of ornithine catabolism", "negative regulation of ornithine breakdown", "down-regulation of ornithine catabolic process", "down regulation of ornithine catabolic process", "inhibition of ornithine degradation", "downregulation of ornithine catabolic process", "inhibition of ornithine catabolic process", "inhibition of ornithine catabolism", "downregulation of ornithine breakdown", "down regulation of ornithine degradation", "negative regulation of ornithine degradation", "down regulation of ornithine breakdown", "down regulation of ornithine catabolism"], "types": ["T044"], "canonical_name": "negative regulation of ornithine catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ornithine catabolic process. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340]"}
{"concept_id": "C3894110", "aliases": ["activation of ornithine breakdown", "activation of ornithine catabolic process", "activation of ornithine degradation", "up-regulation of ornithine degradation", "up regulation of ornithine catabolism", "positive regulation of ornithine degradation", "upregulation of ornithine breakdown", "activation of ornithine catabolism", "upregulation of ornithine catabolic process", "upregulation of ornithine degradation", "up-regulation of ornithine catabolism", "up-regulation of ornithine breakdown", "upregulation of ornithine catabolism", "up-regulation of ornithine catabolic process", "up regulation of ornithine breakdown", "up regulation of ornithine degradation", "positive regulation of ornithine catabolism", "positive regulation of ornithine breakdown", "up regulation of ornithine catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of ornithine catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of ornithine catabolic process. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340]"}
{"concept_id": "C3894111", "aliases": ["OTC-ARGI complex location", "ornithine carbamoyltransferase arginase complex location", "ornithine carbamoyltransferase inhibitor complex location", "ornithine carbamoyltransferase arginase complex", "OTC-ARGI complex"], "types": ["T026"], "canonical_name": "ornithine carbamoyltransferase inhibitor complex", "definition": "A protein complex which is capable of ornithine carbamoyltransferase inhibitor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12679340]"}
{"concept_id": "C3894112", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic translational elongation through polyproline stretches", "definition": "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches. [GO_REF:0000058, GOC:TermGenie, PMID:24923804]"}
{"concept_id": "C3894113", "aliases": ["downregulation of cytoplasmic translational elongation through polyproline stretches", "inhibition of cytoplasmic translational elongation through polyproline stretches", "down-regulation of cytoplasmic translational elongation through polyproline stretches", "down regulation of cytoplasmic translational elongation through polyproline stretches"], "types": ["T043"], "canonical_name": "negative regulation of cytoplasmic translational elongation through polyproline stretches", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches. [GO_REF:0000058, GOC:TermGenie, PMID:24923804]"}
{"concept_id": "C3894114", "aliases": ["up regulation of cytoplasmic translational elongation through polyproline stretches", "activation of cytoplasmic translational elongation through polyproline stretches", "upregulation of cytoplasmic translational elongation through polyproline stretches", "up-regulation of cytoplasmic translational elongation through polyproline stretches"], "types": ["T043"], "canonical_name": "positive regulation of cytoplasmic translational elongation through polyproline stretches", "definition": "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches. [GO_REF:0000058, GOC:TermGenie, PMID:24923804]"}
{"concept_id": "C3894118", "aliases": ["regulation of sodium ion export from cell"], "types": ["T043"], "canonical_name": "regulation of sodium ion export across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]"}
{"concept_id": "C3894119", "aliases": ["downregulation of sodium ion export from cell", "inhibition of sodium ion export from cell", "down regulation of sodium ion export from cell", "down-regulation of sodium ion export from cell", "negative regulation of sodium ion export from cell"], "types": ["T043"], "canonical_name": "negative regulation of sodium ion export across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]"}
{"concept_id": "C3894120", "aliases": ["positive regulation of sodium ion export from cell", "upregulation of sodium ion export from cell", "activation of sodium ion export from cell", "up regulation of sodium ion export from cell", "up-regulation of sodium ion export from cell"], "types": ["T043"], "canonical_name": "positive regulation of sodium ion export across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]"}
{"concept_id": "C3894121", "aliases": ["regulation of mitochondrial sodium/calcium ion exchange", "regulation of sodium/calcium exchanger", "regulation of sodium:calcium exchange"], "types": ["T038"], "canonical_name": "regulation of calcium:sodium antiporter activity", "definition": "Any process that modulates the frequency, rate or extent of calcium:sodium antiporter activity. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]"}
{"concept_id": "C3894122", "aliases": ["downregulation of sodium:calcium exchange", "down-regulation of sodium:calcium exchange", "negative regulation of sodium:calcium exchange", "downregulation of sodium/calcium exchanger", "downregulation of calcium:sodium antiporter activity", "down-regulation of sodium/calcium exchanger", "negative regulation of sodium/calcium exchanger", "down-regulation of mitochondrial sodium/calcium ion exchange", "down regulation of sodium:calcium exchange", "down regulation of sodium/calcium exchanger", "inhibition of calcium:sodium antiporter activity", "inhibition of mitochondrial sodium/calcium ion exchange", "down-regulation of calcium:sodium antiporter activity", "downregulation of mitochondrial sodium/calcium ion exchange", "down regulation of mitochondrial sodium/calcium ion exchange", "inhibition of sodium/calcium exchanger", "down regulation of calcium:sodium antiporter activity", "negative regulation of mitochondrial sodium/calcium ion exchange", "inhibition of sodium:calcium exchange"], "types": ["T044"], "canonical_name": "negative regulation of calcium:sodium antiporter activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]"}
{"concept_id": "C3894123", "aliases": ["activation of calcium:sodium antiporter activity", "activation of mitochondrial sodium/calcium ion exchange", "up-regulation of sodium/calcium exchanger", "positive regulation of mitochondrial sodium/calcium ion exchange", "activation of sodium/calcium exchanger", "up-regulation of calcium:sodium antiporter activity", "upregulation of sodium:calcium exchange", "positive regulation of sodium/calcium exchanger", "up regulation of sodium/calcium exchanger", "up regulation of calcium:sodium antiporter activity", "up regulation of mitochondrial sodium/calcium ion exchange", "up regulation of sodium:calcium exchange", "activation of sodium:calcium exchange", "up-regulation of sodium:calcium exchange", "upregulation of sodium/calcium exchanger", "positive regulation of sodium:calcium exchange", "up-regulation of mitochondrial sodium/calcium ion exchange", "upregulation of mitochondrial sodium/calcium ion exchange", "upregulation of calcium:sodium antiporter activity"], "types": ["T038"], "canonical_name": "positive regulation of calcium:sodium antiporter activity", "definition": "Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]"}
{"concept_id": "C3894124", "aliases": ["regulation of reduced glutathione peroxidase activity", "regulation of GSH peroxidase activity", "regulation of selenium-glutathione peroxidase activity", "regulation of glutathione:hydrogen-peroxide oxidoreductase activity", "regulation of non-selenium glutathione peroxidase activity"], "types": ["T044"], "canonical_name": "regulation of glutathione peroxidase activity", "definition": "Any process that modulates the frequency, rate or extent of glutathione peroxidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894125", "aliases": ["down-regulation of selenium-glutathione peroxidase activity", "inhibition of non-selenium glutathione peroxidase activity", "down regulation of reduced glutathione peroxidase activity", "down-regulation of GSH peroxidase activity", "down-regulation of reduced glutathione peroxidase activity", "negative regulation of reduced glutathione peroxidase activity", "down-regulation of glutathione:hydrogen-peroxide oxidoreductase activity", "down regulation of selenium-glutathione peroxidase activity", "inhibition of glutathione peroxidase activity", "down regulation of glutathione:hydrogen-peroxide oxidoreductase activity", "downregulation of reduced glutathione peroxidase activity", "negative regulation of selenium-glutathione peroxidase activity", "inhibition of selenium-glutathione peroxidase activity", "inhibition of reduced glutathione peroxidase activity", "inhibition of GSH peroxidase activity", "inhibition of glutathione:hydrogen-peroxide oxidoreductase activity", "negative regulation of GSH peroxidase activity", "downregulation of glutathione peroxidase activity", "down regulation of glutathione peroxidase activity", "downregulation of non-selenium glutathione peroxidase activity", "negative regulation of non-selenium glutathione peroxidase activity", "down-regulation of glutathione peroxidase activity", "down regulation of GSH peroxidase activity", "downregulation of GSH peroxidase activity", "negative regulation of glutathione:hydrogen-peroxide oxidoreductase activity", "downregulation of glutathione:hydrogen-peroxide oxidoreductase activity", "downregulation of selenium-glutathione peroxidase activity"], "types": ["T044"], "canonical_name": "negative regulation of glutathione peroxidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glutathione peroxidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894126", "aliases": ["down-regulation of non-selenium glutathione peroxidase activity"], "types": ["T044"], "canonical_name": "down regulation of non-selenium glutathione peroxidase activity"}
{"concept_id": "C3894127", "aliases": ["activation of glutathione peroxidase activity", "upregulation of selenium-glutathione peroxidase activity", "up-regulation of glutathione:hydrogen-peroxide oxidoreductase activity", "positive regulation of GSH peroxidase activity", "upregulation of reduced glutathione peroxidase activity", "upregulation of glutathione:hydrogen-peroxide oxidoreductase activity", "activation of GSH peroxidase activity", "positive regulation of selenium-glutathione peroxidase activity", "up-regulation of glutathione peroxidase activity", "up regulation of reduced glutathione peroxidase activity", "up-regulation of reduced glutathione peroxidase activity", "positive regulation of reduced glutathione peroxidase activity", "positive regulation of glutathione:hydrogen-peroxide oxidoreductase activity", "up-regulation of selenium-glutathione peroxidase activity", "up-regulation of GSH peroxidase activity", "enhancement of GPX activity", "upregulation of GSH peroxidase activity", "up regulation of GSH peroxidase activity", "activation of glutathione:hydrogen-peroxide oxidoreductase activity", "up regulation of glutathione:hydrogen-peroxide oxidoreductase activity", "upregulation of glutathione peroxidase activity", "up regulation of glutathione peroxidase activity", "up regulation of selenium-glutathione peroxidase activity"], "types": ["T044"], "canonical_name": "positive regulation of glutathione peroxidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046]"}
{"concept_id": "C3894128", "aliases": ["positive regulation of non-selenium glutathione peroxidase activity", "activation of reduced glutathione peroxidase activity", "activation of selenium-glutathione peroxidase activity", "upregulation of non-selenium glutathione peroxidase activity"], "types": ["T044"], "canonical_name": "activation of non-selenium glutathione peroxidase activity"}
{"concept_id": "C3894129", "aliases": ["up-regulation of non-selenium glutathione peroxidase activity"], "types": ["T044"], "canonical_name": "up regulation of non-selenium glutathione peroxidase activity"}
{"concept_id": "C3894130", "aliases": ["activation of hydrogen peroxide removal", "positive regulation of H2O2 scavenging", "up regulation of hydrogen peroxide degradation", "positive regulation of detoxification of hydrogen peroxide", "up regulation of hydrogen peroxide breakdown", "up-regulation of hydrogen peroxide catabolic process", "upregulation of hydrogen peroxide catabolism", "positive regulation of hydrogen peroxide catabolism", "positive regulation of H2O2 catabolic process", "up-regulation of hydrogen peroxide breakdown", "activation of detoxification of hydrogen peroxide", "upregulation of hydrogen peroxide catabolic process", "upregulation of H2O2 catabolic process", "up-regulation of hydrogen peroxide catabolism", "up-regulation of H2O2 catabolic process", "positive regulation of hydrogen peroxide degradation", "up regulation of hydrogen peroxide catabolism", "positive regulation of hydrogen peroxide breakdown", "activation of H2O2 scavenging", "upregulation of hydrogen peroxide degradation", "up regulation of hydrogen peroxide catabolic process", "activation of detoxification of H2O2", "activation of hydrogen peroxide breakdown", "up regulation of H2O2 catabolic process", "positive regulation of hydrogen peroxide removal", "activation of hydrogen peroxide degradation", "activation of hydrogen peroxide catabolism", "positive regulation of detoxification of H2O2", "activation of hydrogen peroxide catabolic process", "positive regulation of hydrogen peroxide scavenging", "up-regulation of hydrogen peroxide degradation", "upregulation of hydrogen peroxide breakdown", "activation of hydrogen peroxide scavenging", "activation of H2O2 catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of hydrogen peroxide catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046]"}
{"concept_id": "C3894131", "aliases": ["up regulation of hydrogen peroxide removal", "up-regulation of H2O2 scavenging", "up-regulation of hydrogen peroxide scavenging", "up-regulation of detoxification of H2O2", "up-regulation of detoxification of hydrogen peroxide", "upregulation of detoxification of H2O2", "upregulation of H2O2 scavenging", "upregulation of hydrogen peroxide removal", "upregulation of hydrogen peroxide scavenging", "upregulation of detoxification of hydrogen peroxide", "up regulation of detoxification of H2O2", "up regulation of detoxification of hydrogen peroxide", "up regulation of hydrogen peroxide scavenging", "up-regulation of hydrogen peroxide removal"], "types": ["T044"], "canonical_name": "up regulation of H2O2 scavenging"}
{"concept_id": "C3894132", "aliases": ["regulation of potassium import", "regulation of potassium ion uptake"], "types": ["T043"], "canonical_name": "regulation of potassium ion import", "definition": "Any process that modulates the frequency, rate or extent of potassium ion import. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]"}
{"concept_id": "C3894133", "aliases": ["down-regulation of potassium import", "down regulation of potassium ion import", "downregulation of potassium ion uptake", "down-regulation of potassium ion import", "down regulation of potassium ion uptake", "downregulation of potassium import", "negative regulation of potassium ion uptake", "inhibition of potassium ion uptake", "inhibition of potassium ion import", "negative regulation of potassium import", "downregulation of potassium ion import", "down regulation of potassium import", "inhibition of potassium import", "down-regulation of potassium ion uptake"], "types": ["T043"], "canonical_name": "negative regulation of potassium ion import"}
{"concept_id": "C3894134", "aliases": ["positive regulation of potassium ion uptake", "up regulation of potassium import", "upregulation of potassium import", "up regulation of potassium ion import", "upregulation of potassium ion uptake", "upregulation of potassium ion import", "activation of potassium import", "up regulation of potassium ion uptake", "activation of potassium ion uptake", "up-regulation of potassium ion import", "activation of potassium ion import", "positive regulation of potassium import", "positive regulation of potassium ion import", "up-regulation of potassium import", "up-regulation of potassium ion uptake"], "types": ["T043"], "canonical_name": "positive regulation of potassium ion import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]"}
{"concept_id": "C3894138", "aliases": ["protein localisation in Golgi membrane", "protein localisation to Golgi membrane", "protein localization in Golgi membrane"], "types": ["T043"], "canonical_name": "protein localization to Golgi membrane", "definition": "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. [GO_REF:0000087, GOC:TermGenie, PMID:11378902]"}
{"concept_id": "C3894139", "aliases": ["phosphatase complex location"], "types": ["T026"], "canonical_name": "phosphatase complex", "definition": "A protein complex which is capable of phosphatase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807]"}
{"concept_id": "C3894140", "aliases": [], "types": ["T038"], "canonical_name": "regulation of glutamate secretion, neurotransmission", "definition": "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission. [GO_REF:0000058, GOC:TermGenie, PMID:16782817]"}
{"concept_id": "C3894141", "aliases": ["inhibition of glutamate secretion, neurotransmission", "downregulation of glutamate secretion, neurotransmission", "down regulation of glutamate secretion, neurotransmission", "down-regulation of glutamate secretion, neurotransmission"], "types": ["T043"], "canonical_name": "negative regulation of glutamate secretion, neurotransmission", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission. [GO_REF:0000058, GOC:TermGenie, PMID:16782817]"}
{"concept_id": "C3894142", "aliases": ["activation of glutamate secretion, neurotransmission", "up-regulation of glutamate secretion, neurotransmission", "upregulation of glutamate secretion, neurotransmission", "up regulation of glutamate secretion, neurotransmission"], "types": ["T043"], "canonical_name": "positive regulation of glutamate secretion, neurotransmission", "definition": "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter. [GO_REF:0000058, GOC:TermGenie, PMID:16782817]"}
{"concept_id": "C3894143", "aliases": ["regulation of intrinsic apoptotic signaling pathway in response to hypoxia", "regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway", "regulation of hypoxia-induced apoptosis"], "types": ["T043"], "canonical_name": "regulation of hypoxia-induced intrinsic apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894144", "aliases": ["inhibition of intrinsic apoptotic signaling pathway in response to hypoxia", "down-regulation of intrinsic apoptotic signaling pathway in response to hypoxia", "down regulation of intrinsic apoptotic signaling pathway in response to hypoxia", "negative regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway", "downregulation of intrinsic apoptotic signaling pathway in response to hypoxia", "negative regulation of intrinsic apoptotic signaling pathway in response to hypoxia"], "types": ["T043"], "canonical_name": "negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24553947]"}
{"concept_id": "C3894145", "aliases": ["protection against hypoxia-induced apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of hypoxia-induced apoptosis"}
{"concept_id": "C3894146", "aliases": ["regulation of glucose ATP phosphotransferase activity", "regulation of ATP:D-hexose 6-phosphotransferase activity", "regulation of hexokinase (phosphorylating)", "regulation of hexokinase type IV glucokinase activity", "regulation of ATP-dependent hexokinase activity", "regulation of hexokinase type IV (glucokinase) activity"], "types": ["T044"], "canonical_name": "regulation of hexokinase activity", "definition": "Any process that modulates the frequency, rate or extent of hexokinase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]"}
{"concept_id": "C3894147", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hexokinase D"}
{"concept_id": "C3894148", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hexokinase type I activity"}
{"concept_id": "C3894149", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hexokinase type II activity"}
{"concept_id": "C3894150", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hexokinase type III activity"}
{"concept_id": "C3894151", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hexokinase type IV"}
{"concept_id": "C3894152", "aliases": ["negative regulation of hexokinase (phosphorylating)", "down-regulation of glucose ATP phosphotransferase activity", "negative regulation of ATP-dependent hexokinase activity", "down regulation of ATP-dependent hexokinase activity", "negative regulation of hexokinase type IV (glucokinase) activity", "down regulation of hexokinase type IV glucokinase activity", "negative regulation of hexokinase type IV glucokinase activity", "negative regulation of glucose ATP phosphotransferase activity", "down regulation of hexokinase activity", "down regulation of hexokinase type IV (glucokinase) activity", "down-regulation of hexokinase type IV (glucokinase) activity", "down regulation of hexokinase (phosphorylating)", "downregulation of glucose ATP phosphotransferase activity", "down regulation of glucose ATP phosphotransferase activity", "down-regulation of ATP:D-hexose 6-phosphotransferase activity", "downregulation of hexokinase (phosphorylating)", "down-regulation of hexokinase (phosphorylating)", "downregulation of ATP-dependent hexokinase activity", "downregulation of hexokinase type IV glucokinase activity", "down-regulation of hexokinase activity", "down regulation of ATP:D-hexose 6-phosphotransferase activity", "downregulation of ATP:D-hexose 6-phosphotransferase activity", "downregulation of hexokinase activity", "down-regulation of ATP-dependent hexokinase activity", "down-regulation of hexokinase type IV glucokinase activity", "negative regulation of ATP:D-hexose 6-phosphotransferase activity"], "types": ["T044"], "canonical_name": "negative regulation of hexokinase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hexokinase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]"}
{"concept_id": "C3894153", "aliases": ["downregulation of hexokinase D", "down-regulation of hexokinase D"], "types": ["T043"], "canonical_name": "down regulation of hexokinase D"}
{"concept_id": "C3894154", "aliases": ["down-regulation of hexokinase type I activity", "downregulation of hexokinase type I activity"], "types": ["T043"], "canonical_name": "down regulation of hexokinase type I activity"}
{"concept_id": "C3894155", "aliases": ["down-regulation of hexokinase type II activity", "downregulation of hexokinase type II activity"], "types": ["T043"], "canonical_name": "down regulation of hexokinase type II activity"}
{"concept_id": "C3894156", "aliases": ["down-regulation of hexokinase type III activity", "downregulation of hexokinase type III activity"], "types": ["T043"], "canonical_name": "down regulation of hexokinase type III activity"}
{"concept_id": "C3894157", "aliases": ["down-regulation of hexokinase type IV", "downregulation of hexokinase type IV (glucokinase) activity", "downregulation of hexokinase type IV"], "types": ["T043"], "canonical_name": "down regulation of hexokinase type IV"}
{"concept_id": "C3894158", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATP-dependent hexokinase activity"}
{"concept_id": "C3894159", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATP:D-hexose 6-phosphotransferase activity"}
{"concept_id": "C3894160", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glucose ATP phosphotransferase activity"}
{"concept_id": "C3894161", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hexokinase (phosphorylating)"}
{"concept_id": "C3894162", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hexokinase activity"}
{"concept_id": "C3894163", "aliases": ["negative regulation of hexokinase D"], "types": ["T043"], "canonical_name": "inhibition of hexokinase D"}
{"concept_id": "C3894164", "aliases": ["negative regulation of hexokinase type I activity"], "types": ["T043"], "canonical_name": "inhibition of hexokinase type I activity"}
{"concept_id": "C3894165", "aliases": ["negative regulation of hexokinase type II activity"], "types": ["T043"], "canonical_name": "inhibition of hexokinase type II activity"}
{"concept_id": "C3894166", "aliases": ["negative regulation of hexokinase type III activity"], "types": ["T043"], "canonical_name": "inhibition of hexokinase type III activity"}
{"concept_id": "C3894167", "aliases": ["negative regulation of hexokinase type IV"], "types": ["T043"], "canonical_name": "inhibition of hexokinase type IV"}
{"concept_id": "C3894168", "aliases": ["inhibition of hexokinase type IV glucokinase activity"], "types": ["T043"], "canonical_name": "inhibition of hexokinase type IV (glucokinase) activity"}
{"concept_id": "C3894169", "aliases": ["up-regulation of ATP:D-hexose 6-phosphotransferase activity", "upregulation of ATP:D-hexose 6-phosphotransferase activity", "upregulation of glucose ATP phosphotransferase activity", "positive regulation of ATP-dependent hexokinase activity", "up-regulation of ATP-dependent hexokinase activity", "up-regulation of glucose ATP phosphotransferase activity", "up regulation of ATP-dependent hexokinase activity", "positive regulation of hexokinase (phosphorylating)", "upregulation of ATP-dependent hexokinase activity", "upregulation of hexokinase (phosphorylating)", "up regulation of glucose ATP phosphotransferase activity", "up-regulation of hexokinase activity", "up regulation of hexokinase (phosphorylating)", "up regulation of hexokinase activity", "up-regulation of hexokinase type IV glucokinase activity", "upregulation of hexokinase activity", "positive regulation of ATP:D-hexose 6-phosphotransferase activity", "positive regulation of glucose ATP phosphotransferase activity", "up regulation of ATP:D-hexose 6-phosphotransferase activity", "up-regulation of hexokinase (phosphorylating)"], "types": ["T044"], "canonical_name": "positive regulation of hexokinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of hexokinase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]"}
{"concept_id": "C3894170", "aliases": ["activation of ATP:D-hexose 6-phosphotransferase activity", "activation of hexokinase activity", "activation of glucose ATP phosphotransferase activity", "activation of hexokinase (phosphorylating)"], "types": ["T044"], "canonical_name": "activation of ATP-dependent hexokinase activity"}
{"concept_id": "C3894171", "aliases": [], "types": ["T044"], "canonical_name": "activation of hexokinase D"}
{"concept_id": "C3894172", "aliases": [], "types": ["T044"], "canonical_name": "activation of hexokinase type I activity"}
{"concept_id": "C3894173", "aliases": [], "types": ["T044"], "canonical_name": "activation of hexokinase type II activity"}
{"concept_id": "C3894174", "aliases": [], "types": ["T044"], "canonical_name": "activation of hexokinase type III activity"}
{"concept_id": "C3894175", "aliases": [], "types": ["T044"], "canonical_name": "activation of hexokinase type IV"}
{"concept_id": "C3894176", "aliases": ["activation of hexokinase type IV glucokinase activity"], "types": ["T044"], "canonical_name": "activation of hexokinase type IV (glucokinase) activity"}
{"concept_id": "C3894177", "aliases": ["up regulation of hexokinase D", "upregulation of hexokinase D", "up-regulation of hexokinase D"], "types": ["T044"], "canonical_name": "positive regulation of hexokinase D"}
{"concept_id": "C3894178", "aliases": ["up regulation of hexokinase type I activity", "upregulation of hexokinase type I activity", "up-regulation of hexokinase type I activity"], "types": ["T044"], "canonical_name": "positive regulation of hexokinase type I activity"}
{"concept_id": "C3894179", "aliases": ["up-regulation of hexokinase type II activity", "upregulation of hexokinase type II activity", "up regulation of hexokinase type II activity"], "types": ["T044"], "canonical_name": "positive regulation of hexokinase type II activity"}
{"concept_id": "C3894180", "aliases": ["up regulation of hexokinase type III activity", "up-regulation of hexokinase type III activity", "upregulation of hexokinase type III activity"], "types": ["T044"], "canonical_name": "positive regulation of hexokinase type III activity"}
{"concept_id": "C3894181", "aliases": ["positive regulation of hexokinase type IV glucokinase activity", "positive regulation of hexokinase type IV (glucokinase) activity"], "types": ["T044"], "canonical_name": "positive regulation of hexokinase type IV"}
{"concept_id": "C3894182", "aliases": ["regulation of ATP:pyruvate 2-O-phosphotransferase activity", "regulation of phosphoenolpyruvate kinase activity", "regulation of phosphoenol transphosphorylase activity"], "types": ["T044"], "canonical_name": "regulation of pyruvate kinase activity", "definition": "Any process that modulates the frequency, rate or extent of pyruvate kinase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]"}
{"concept_id": "C3894183", "aliases": ["down-regulation of ATP:pyruvate 2-O-phosphotransferase activity", "inhibition of pyruvate kinase activity", "down-regulation of pyruvate kinase activity", "down regulation of ATP:pyruvate 2-O-phosphotransferase activity", "negative regulation of ATP:pyruvate 2-O-phosphotransferase activity", "inhibition of phosphoenolpyruvate kinase activity", "inhibition of phosphoenol transphosphorylase activity", "downregulation of ATP:pyruvate 2-O-phosphotransferase activity", "down regulation of phosphoenolpyruvate kinase activity", "negative regulation of phosphoenol transphosphorylase activity", "downregulation of phosphoenolpyruvate kinase activity", "downregulation of phosphoenol transphosphorylase activity", "down-regulation of phosphoenol transphosphorylase activity", "down regulation of pyruvate kinase activity", "downregulation of pyruvate kinase activity", "down regulation of phosphoenol transphosphorylase activity", "inhibition of ATP:pyruvate 2-O-phosphotransferase activity", "negative regulation of phosphoenolpyruvate kinase activity", "down-regulation of phosphoenolpyruvate kinase activity"], "types": ["T044"], "canonical_name": "negative regulation of pyruvate kinase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate kinase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]"}
{"concept_id": "C3894184", "aliases": ["up-regulation of ATP:pyruvate 2-O-phosphotransferase activity", "up regulation of phosphoenolpyruvate kinase activity", "positive regulation of phosphoenolpyruvate kinase activity", "up-regulation of pyruvate kinase activity", "up regulation of phosphoenol transphosphorylase activity", "activation of pyruvate kinase activity", "activation of ATP:pyruvate 2-O-phosphotransferase activity", "up regulation of ATP:pyruvate 2-O-phosphotransferase activity", "upregulation of pyruvate kinase activity", "upregulation of phosphoenolpyruvate kinase activity", "upregulation of phosphoenol transphosphorylase activity", "up regulation of pyruvate kinase activity", "activation of phosphoenolpyruvate kinase activity", "positive regulation of phosphoenol transphosphorylase activity", "up-regulation of phosphoenol transphosphorylase activity", "activation of phosphoenol transphosphorylase activity", "upregulation of ATP:pyruvate 2-O-phosphotransferase activity", "up-regulation of phosphoenolpyruvate kinase activity", "positive regulation of ATP:pyruvate 2-O-phosphotransferase activity"], "types": ["T044"], "canonical_name": "positive regulation of pyruvate kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of pyruvate kinase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]"}
{"concept_id": "C3894185", "aliases": [], "types": ["T043"], "canonical_name": "regulation of regulated secretory pathway", "definition": "Any process that modulates the frequency, rate or extent of regulated secretory pathway. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]"}
{"concept_id": "C3894186", "aliases": ["down regulation of regulated secretory pathway", "downregulation of regulated secretory pathway", "down-regulation of regulated secretory pathway"], "types": ["T043"], "canonical_name": "negative regulation of regulated secretory pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]"}
{"concept_id": "C3894187", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of regulated secretory pathway"}
{"concept_id": "C3894188", "aliases": ["up regulation of regulated secretory pathway", "upregulation of regulated secretory pathway", "up-regulation of regulated secretory pathway", "activation of regulated secretory pathway"], "types": ["T043"], "canonical_name": "positive regulation of regulated secretory pathway", "definition": "Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]"}
{"concept_id": "C3894189", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chromatin modification"}
{"concept_id": "C3894190", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of chromatin modification"}
{"concept_id": "C3894191", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of chromatin modification"}
{"concept_id": "C3894192", "aliases": ["regulation of mRNA metabolism"], "types": ["T045"], "canonical_name": "regulation of mRNA metabolic process", "definition": "Any process that modulates the frequency, rate or extent of mRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894193", "aliases": ["down-regulation of mRNA metabolic process", "negative regulation of mRNA metabolism", "downregulation of mRNA metabolic process", "down-regulation of mRNA metabolism", "inhibition of mRNA metabolic process", "down regulation of mRNA metabolic process", "downregulation of mRNA metabolism", "down regulation of mRNA metabolism"], "types": ["T045"], "canonical_name": "negative regulation of mRNA metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894194", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mRNA metabolism"}
{"concept_id": "C3894195", "aliases": ["activation of mRNA metabolism", "up-regulation of mRNA metabolism", "activation of mRNA metabolic process", "positive regulation of mRNA metabolism", "upregulation of mRNA metabolism", "up regulation of mRNA metabolic process", "upregulation of mRNA metabolic process", "up-regulation of mRNA metabolic process", "up regulation of mRNA metabolism"], "types": ["T045"], "canonical_name": "positive regulation of mRNA metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894196", "aliases": [], "types": ["T044"], "canonical_name": "regulation of nitrogen cycle metabolic process", "definition": "Any process that modulates the frequency, rate or extent of nitrogen cycle metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894197", "aliases": ["down regulation of nitrogen cycle metabolic process", "downregulation of nitrogen cycle metabolic process", "down-regulation of nitrogen cycle metabolic process", "inhibition of nitrogen cycle metabolic process"], "types": ["T044"], "canonical_name": "negative regulation of nitrogen cycle metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen cycle metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894198", "aliases": ["up regulation of nitrogen cycle metabolic process", "upregulation of nitrogen cycle metabolic process", "up-regulation of nitrogen cycle metabolic process", "activation of nitrogen cycle metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of nitrogen cycle metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of nitrogen cycle metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894199", "aliases": [], "types": ["T045"], "canonical_name": "regulation of protein maturation", "definition": "Any process that modulates the frequency, rate or extent of protein maturation. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894200", "aliases": ["down regulation of protein maturation", "inhibition of protein maturation", "down-regulation of protein maturation", "downregulation of protein maturation"], "types": ["T045"], "canonical_name": "negative regulation of protein maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894201", "aliases": ["activation of protein maturation", "up regulation of protein maturation", "up-regulation of protein maturation", "upregulation of protein maturation"], "types": ["T045"], "canonical_name": "positive regulation of protein maturation", "definition": "Any process that activates or increases the frequency, rate or extent of protein maturation. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894202", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein modification by small protein conjugation or removal", "definition": "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894203", "aliases": ["inhibition of protein modification by small protein conjugation or removal", "down-regulation of protein modification by small protein conjugation or removal", "downregulation of protein modification by small protein conjugation or removal", "down regulation of protein modification by small protein conjugation or removal"], "types": ["T044"], "canonical_name": "negative regulation of protein modification by small protein conjugation or removal", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894204", "aliases": ["up-regulation of protein modification by small protein conjugation or removal", "activation of protein modification by small protein conjugation or removal", "upregulation of protein modification by small protein conjugation or removal", "up regulation of protein modification by small protein conjugation or removal"], "types": ["T044"], "canonical_name": "positive regulation of protein modification by small protein conjugation or removal", "definition": "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894205", "aliases": ["regulation of snoRNA metabolism"], "types": ["T045"], "canonical_name": "regulation of snoRNA metabolic process", "definition": "Any process that modulates the frequency, rate or extent of snoRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894206", "aliases": ["down regulation of snoRNA metabolism", "downregulation of snoRNA metabolism", "inhibition of snoRNA metabolism", "down-regulation of snoRNA metabolic process", "downregulation of snoRNA metabolic process", "down-regulation of snoRNA metabolism", "inhibition of snoRNA metabolic process", "negative regulation of snoRNA metabolism", "down regulation of snoRNA metabolic process"], "types": ["T045"], "canonical_name": "negative regulation of snoRNA metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894207", "aliases": ["upregulation of snoRNA metabolism", "activation of snoRNA metabolic process", "up regulation of snoRNA metabolism", "up-regulation of snoRNA metabolic process", "upregulation of snoRNA metabolic process", "positive regulation of snoRNA metabolism", "activation of snoRNA metabolism", "up regulation of snoRNA metabolic process", "up-regulation of snoRNA metabolism"], "types": ["T045"], "canonical_name": "positive regulation of snoRNA metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of snoRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894208", "aliases": ["regulation of tRNA metabolism"], "types": ["T045"], "canonical_name": "regulation of tRNA metabolic process", "definition": "Any process that modulates the frequency, rate or extent of tRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894209", "aliases": ["down-regulation of tRNA metabolism", "downregulation of tRNA metabolism", "down-regulation of tRNA metabolic process", "inhibition of tRNA metabolic process", "inhibition of tRNA metabolism", "negative regulation of tRNA metabolism", "down regulation of tRNA metabolism", "downregulation of tRNA metabolic process", "down regulation of tRNA metabolic process"], "types": ["T045"], "canonical_name": "negative regulation of tRNA metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894210", "aliases": ["upregulation of tRNA metabolic process", "up-regulation of tRNA metabolic process", "activation of tRNA metabolic process", "up regulation of tRNA metabolism", "upregulation of tRNA metabolism", "up-regulation of tRNA metabolism", "up regulation of tRNA metabolic process", "activation of tRNA metabolism", "positive regulation of tRNA metabolism"], "types": ["T045"], "canonical_name": "positive regulation of tRNA metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of tRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894211", "aliases": [], "types": ["T044"], "canonical_name": "regulation of iron-sulfur cluster assembly", "definition": "Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894212", "aliases": ["down regulation of iron-sulfur cluster assembly", "down regulation of iron-sulphur cluster assembly", "negative regulation of iron-sulphur cluster assembly", "downregulation of iron-sulfur cluster assembly", "inhibition of iron-sulphur cluster assembly", "downregulation of iron-sulphur cluster assembly", "down-regulation of iron-sulfur cluster assembly", "down-regulation of iron-sulphur cluster assembly", "inhibition of iron-sulfur cluster assembly"], "types": ["T044"], "canonical_name": "negative regulation of iron-sulfur cluster assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur cluster assembly. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894213", "aliases": ["down-regulation of iron-sulfur cluster biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of iron-sulfur cluster biosynthesis"}
{"concept_id": "C3894214", "aliases": ["inhibition of iron-sulfur cluster biosynthesis", "negative regulation of iron-sulfur cluster biosynthesis"], "types": ["T044"], "canonical_name": "downregulation of iron-sulfur cluster biosynthesis"}
{"concept_id": "C3894215", "aliases": ["up-regulation of iron-sulphur cluster assembly", "upregulation of iron-sulfur cluster assembly", "up regulation of iron-sulphur cluster assembly", "upregulation of iron-sulphur cluster assembly", "up regulation of iron-sulfur cluster assembly", "up-regulation of iron-sulfur cluster assembly", "positive regulation of iron-sulphur cluster assembly"], "types": ["T044"], "canonical_name": "positive regulation of iron-sulfur cluster assembly", "definition": "Any process that activates or increases the frequency, rate or extent of iron-sulfur cluster assembly. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894216", "aliases": ["activation of iron-sulphur cluster assembly"], "types": ["T044"], "canonical_name": "activation of iron-sulfur cluster assembly"}
{"concept_id": "C3894217", "aliases": ["upregulation of iron-sulfur cluster biosynthesis", "positive regulation of iron-sulfur cluster biosynthesis"], "types": ["T044"], "canonical_name": "activation of iron-sulfur cluster biosynthesis"}
{"concept_id": "C3894218", "aliases": ["up-regulation of iron-sulfur cluster biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of iron-sulfur cluster biosynthesis"}
{"concept_id": "C3894219", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein folding", "definition": "Any process that modulates the frequency, rate or extent of protein folding. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894220", "aliases": [], "types": ["T044"], "canonical_name": "regulation of alpha-tubulin folding"}
{"concept_id": "C3894221", "aliases": [], "types": ["T044"], "canonical_name": "regulation of beta-tubulin folding"}
{"concept_id": "C3894222", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chaperone activity"}
{"concept_id": "C3894223", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chaperonin ATPase activity"}
{"concept_id": "C3894224", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chaperonin-mediated tubulin folding"}
{"concept_id": "C3894225", "aliases": ["regulation of co-chaperonin activity"], "types": ["T044"], "canonical_name": "regulation of co-chaperone activity"}
{"concept_id": "C3894226", "aliases": [], "types": ["T044"], "canonical_name": "regulation of glycoprotein-specific chaperone activity"}
{"concept_id": "C3894227", "aliases": [], "types": ["T044"], "canonical_name": "regulation of non-chaperonin molecular chaperone ATPase activity"}
{"concept_id": "C3894228", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein complex assembly, multichaperone pathway"}
{"concept_id": "C3894229", "aliases": ["down regulation of protein folding", "down-regulation of beta-tubulin folding", "downregulation of protein folding", "down-regulation of protein folding", "down regulation of beta-tubulin folding"], "types": ["T044"], "canonical_name": "negative regulation of protein folding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein folding. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894230", "aliases": ["down-regulation of alpha-tubulin folding"], "types": ["T044"], "canonical_name": "down regulation of alpha-tubulin folding"}
{"concept_id": "C3894231", "aliases": ["down-regulation of chaperone activity"], "types": ["T044"], "canonical_name": "down regulation of chaperone activity"}
{"concept_id": "C3894232", "aliases": ["down-regulation of chaperonin ATPase activity"], "types": ["T044"], "canonical_name": "down regulation of chaperonin ATPase activity"}
{"concept_id": "C3894233", "aliases": ["down-regulation of chaperonin-mediated tubulin folding"], "types": ["T044"], "canonical_name": "down regulation of chaperonin-mediated tubulin folding"}
{"concept_id": "C3894234", "aliases": ["down-regulation of co-chaperone activity"], "types": ["T044"], "canonical_name": "down regulation of co-chaperone activity"}
{"concept_id": "C3894235", "aliases": ["down-regulation of co-chaperonin activity"], "types": ["T044"], "canonical_name": "down regulation of co-chaperonin activity"}
{"concept_id": "C3894236", "aliases": ["down-regulation of glycoprotein-specific chaperone activity"], "types": ["T044"], "canonical_name": "down regulation of glycoprotein-specific chaperone activity"}
{"concept_id": "C3894237", "aliases": ["down-regulation of non-chaperonin molecular chaperone ATPase activity"], "types": ["T044"], "canonical_name": "down regulation of non-chaperonin molecular chaperone ATPase activity"}
{"concept_id": "C3894238", "aliases": ["down-regulation of protein complex assembly, multichaperone pathway"], "types": ["T044"], "canonical_name": "down regulation of protein complex assembly, multichaperone pathway"}
{"concept_id": "C3894239", "aliases": ["negative regulation of alpha-tubulin folding", "inhibition of alpha-tubulin folding"], "types": ["T044"], "canonical_name": "downregulation of alpha-tubulin folding"}
{"concept_id": "C3894240", "aliases": ["negative regulation of beta-tubulin folding", "inhibition of beta-tubulin folding"], "types": ["T044"], "canonical_name": "downregulation of beta-tubulin folding"}
{"concept_id": "C3894241", "aliases": ["negative regulation of chaperone activity", "inhibition of chaperone activity"], "types": ["T044"], "canonical_name": "downregulation of chaperone activity"}
{"concept_id": "C3894242", "aliases": ["inhibition of chaperonin ATPase activity"], "types": ["T044"], "canonical_name": "downregulation of chaperonin ATPase activity"}
{"concept_id": "C3894243", "aliases": ["inhibition of chaperonin-mediated tubulin folding"], "types": ["T044"], "canonical_name": "downregulation of chaperonin-mediated tubulin folding"}
{"concept_id": "C3894244", "aliases": ["inhibition of co-chaperonin activity", "inhibition of co-chaperone activity", "downregulation of co-chaperonin activity"], "types": ["T044"], "canonical_name": "downregulation of co-chaperone activity"}
{"concept_id": "C3894245", "aliases": ["inhibition of glycoprotein-specific chaperone activity"], "types": ["T044"], "canonical_name": "downregulation of glycoprotein-specific chaperone activity"}
{"concept_id": "C3894246", "aliases": ["inhibition of non-chaperonin molecular chaperone ATPase activity"], "types": ["T044"], "canonical_name": "downregulation of non-chaperonin molecular chaperone ATPase activity"}
{"concept_id": "C3894247", "aliases": ["inhibition of protein complex assembly, multichaperone pathway"], "types": ["T044"], "canonical_name": "downregulation of protein complex assembly, multichaperone pathway"}
{"concept_id": "C3894248", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein folding"}
{"concept_id": "C3894249", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of chaperonin ATPase activity"}
{"concept_id": "C3894250", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of chaperonin-mediated tubulin folding"}
{"concept_id": "C3894251", "aliases": ["negative regulation of co-chaperonin activity"], "types": ["T044"], "canonical_name": "negative regulation of co-chaperone activity"}
{"concept_id": "C3894252", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of glycoprotein-specific chaperone activity"}
{"concept_id": "C3894253", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of non-chaperonin molecular chaperone ATPase activity"}
{"concept_id": "C3894254", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein complex assembly, multichaperone pathway"}
{"concept_id": "C3894255", "aliases": ["up-regulation of non-chaperonin molecular chaperone ATPase activity", "up regulation of co-chaperonin activity", "up-regulation of protein folding", "up-regulation of chaperonin-mediated tubulin folding", "up regulation of protein folding", "up regulation of non-chaperonin molecular chaperone ATPase activity", "upregulation of protein folding", "up-regulation of co-chaperonin activity", "up regulation of chaperonin-mediated tubulin folding"], "types": ["T044"], "canonical_name": "positive regulation of protein folding", "definition": "Any process that activates or increases the frequency, rate or extent of protein folding. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894256", "aliases": [], "types": ["T044"], "canonical_name": "activation of alpha-tubulin folding"}
{"concept_id": "C3894257", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-tubulin folding"}
{"concept_id": "C3894258", "aliases": [], "types": ["T044"], "canonical_name": "activation of chaperone activity"}
{"concept_id": "C3894259", "aliases": [], "types": ["T044"], "canonical_name": "activation of chaperonin ATPase activity"}
{"concept_id": "C3894260", "aliases": [], "types": ["T044"], "canonical_name": "activation of chaperonin-mediated tubulin folding"}
{"concept_id": "C3894261", "aliases": ["activation of co-chaperonin activity"], "types": ["T044"], "canonical_name": "activation of co-chaperone activity"}
{"concept_id": "C3894262", "aliases": [], "types": ["T044"], "canonical_name": "activation of glycoprotein-specific chaperone activity"}
{"concept_id": "C3894263", "aliases": [], "types": ["T044"], "canonical_name": "activation of non-chaperonin molecular chaperone ATPase activity"}
{"concept_id": "C3894264", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein complex assembly, multichaperone pathway"}
{"concept_id": "C3894265", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein folding"}
{"concept_id": "C3894266", "aliases": ["upregulation of alpha-tubulin folding"], "types": ["T044"], "canonical_name": "positive regulation of alpha-tubulin folding"}
{"concept_id": "C3894267", "aliases": ["upregulation of beta-tubulin folding"], "types": ["T044"], "canonical_name": "positive regulation of beta-tubulin folding"}
{"concept_id": "C3894268", "aliases": ["upregulation of chaperone activity", "up-regulation of chaperone activity", "up regulation of chaperone activity"], "types": ["T044"], "canonical_name": "positive regulation of chaperone activity"}
{"concept_id": "C3894269", "aliases": ["up regulation of chaperonin ATPase activity", "up-regulation of chaperonin ATPase activity", "upregulation of chaperonin ATPase activity"], "types": ["T044"], "canonical_name": "positive regulation of chaperonin ATPase activity"}
{"concept_id": "C3894270", "aliases": ["upregulation of chaperonin-mediated tubulin folding"], "types": ["T044"], "canonical_name": "positive regulation of chaperonin-mediated tubulin folding"}
{"concept_id": "C3894271", "aliases": ["upregulation of co-chaperone activity"], "types": ["T044"], "canonical_name": "positive regulation of co-chaperone activity"}
{"concept_id": "C3894272", "aliases": ["upregulation of co-chaperonin activity"], "types": ["T044"], "canonical_name": "positive regulation of co-chaperonin activity"}
{"concept_id": "C3894273", "aliases": ["upregulation of glycoprotein-specific chaperone activity"], "types": ["T044"], "canonical_name": "positive regulation of glycoprotein-specific chaperone activity"}
{"concept_id": "C3894274", "aliases": ["upregulation of non-chaperonin molecular chaperone ATPase activity"], "types": ["T044"], "canonical_name": "positive regulation of non-chaperonin molecular chaperone ATPase activity"}
{"concept_id": "C3894275", "aliases": ["up-regulation of protein complex assembly, multichaperone pathway", "upregulation of protein complex assembly, multichaperone pathway", "up regulation of protein complex assembly, multichaperone pathway"], "types": ["T044"], "canonical_name": "positive regulation of protein complex assembly, multichaperone pathway"}
{"concept_id": "C3894276", "aliases": ["up-regulation of alpha-tubulin folding"], "types": ["T044"], "canonical_name": "up regulation of alpha-tubulin folding"}
{"concept_id": "C3894277", "aliases": ["up-regulation of beta-tubulin folding"], "types": ["T044"], "canonical_name": "up regulation of beta-tubulin folding"}
{"concept_id": "C3894278", "aliases": ["up-regulation of co-chaperone activity"], "types": ["T044"], "canonical_name": "up regulation of co-chaperone activity"}
{"concept_id": "C3894279", "aliases": ["up-regulation of glycoprotein-specific chaperone activity"], "types": ["T044"], "canonical_name": "up regulation of glycoprotein-specific chaperone activity"}
{"concept_id": "C3894280", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vacuolar transport", "definition": "Any process that modulates the frequency, rate or extent of vacuolar transport. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894281", "aliases": ["downregulation of vacuolar transport", "down-regulation of vacuolar transport", "down regulation of vacuolar transport"], "types": ["T043"], "canonical_name": "negative regulation of vacuolar transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894282", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vacuolar transport"}
{"concept_id": "C3894283", "aliases": ["up-regulation of vacuolar transport", "up regulation of vacuolar transport", "upregulation of vacuolar transport"], "types": ["T043"], "canonical_name": "positive regulation of vacuolar transport", "definition": "Any process that activates or increases the frequency, rate or extent of vacuolar transport. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894284", "aliases": [], "types": ["T043"], "canonical_name": "activation of vacuolar transport"}
{"concept_id": "C3894285", "aliases": ["regulation of cell wall organization or biogenesis at cellular level", "regulation of cell wall organisation or biogenesis", "regulation of cellular cell wall organization or biogenesis", "regulation of cellular cell wall organisation or biogenesis"], "types": ["T043"], "canonical_name": "regulation of cell wall organization or biogenesis", "definition": "Any process that modulates the frequency, rate or extent of cell wall organization or biogenesis. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894286", "aliases": ["downregulation of cell wall organization or biogenesis", "negative regulation of cellular cell wall organization or biogenesis", "down regulation of cell wall organization or biogenesis at cellular level", "down regulation of cell wall organisation or biogenesis", "down-regulation of cellular cell wall organisation or biogenesis", "negative regulation of cell wall organisation or biogenesis", "negative regulation of cell wall organization or biogenesis at cellular level", "down regulation of cellular cell wall organization or biogenesis", "downregulation of cellular cell wall organization or biogenesis", "downregulation of cellular cell wall organisation or biogenesis", "down-regulation of cell wall organisation or biogenesis", "negative regulation of cellular cell wall organisation or biogenesis", "down-regulation of cell wall organization or biogenesis", "down regulation of cellular cell wall organisation or biogenesis", "down-regulation of cell wall organization or biogenesis at cellular level", "downregulation of cell wall organization or biogenesis at cellular level", "downregulation of cell wall organisation or biogenesis", "down regulation of cell wall organization or biogenesis", "down-regulation of cellular cell wall organization or biogenesis"], "types": ["T043"], "canonical_name": "negative regulation of cell wall organization or biogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall organization or biogenesis. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894287", "aliases": ["inhibition of cell wall organization or biogenesis"], "types": ["T043"], "canonical_name": "inhibition of cell wall organisation or biogenesis"}
{"concept_id": "C3894288", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell wall organization or biogenesis at cellular level"}
{"concept_id": "C3894289", "aliases": ["inhibition of cellular cell wall organization or biogenesis"], "types": ["T043"], "canonical_name": "inhibition of cellular cell wall organisation or biogenesis"}
{"concept_id": "C3894290", "aliases": ["upregulation of cell wall organization or biogenesis", "up-regulation of cell wall organization or biogenesis", "up regulation of cell wall organisation or biogenesis", "up-regulation of cellular cell wall organisation or biogenesis", "up-regulation of cell wall organization or biogenesis at cellular level", "positive regulation of cellular cell wall organisation or biogenesis", "up regulation of cell wall organization or biogenesis at cellular level", "up regulation of cell wall organization or biogenesis", "upregulation of cell wall organization or biogenesis at cellular level", "upregulation of cell wall organisation or biogenesis", "up-regulation of cell wall organisation or biogenesis", "up regulation of cellular cell wall organization or biogenesis", "upregulation of cellular cell wall organization or biogenesis", "positive regulation of cellular cell wall organization or biogenesis", "up-regulation of cellular cell wall organization or biogenesis", "activation of cell wall organization or biogenesis", "positive regulation of cell wall organisation or biogenesis", "positive regulation of cell wall organization or biogenesis at cellular level", "activation of cell wall organisation or biogenesis", "up regulation of cellular cell wall organisation or biogenesis", "upregulation of cellular cell wall organisation or biogenesis"], "types": ["T043"], "canonical_name": "positive regulation of cell wall organization or biogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of cell wall organization or biogenesis. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894291", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell wall organization or biogenesis at cellular level"}
{"concept_id": "C3894292", "aliases": ["activation of cellular cell wall organization or biogenesis"], "types": ["T043"], "canonical_name": "activation of cellular cell wall organisation or biogenesis"}
{"concept_id": "C3894293", "aliases": [], "types": ["T043"], "canonical_name": "regulation of meiotic DNA double-strand break formation", "definition": "Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation. [GO_REF:0000058, GOC:TermGenie, PMID:25103240]"}
{"concept_id": "C3894294", "aliases": ["down-regulation of meiotic DNA double-strand break formation", "down regulation of meiotic DNA double-strand break formation", "downregulation of meiotic DNA double-strand break formation"], "types": ["T044"], "canonical_name": "negative regulation of meiotic DNA double-strand break formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation. [GO_REF:0000058, GOC:TermGenie, PMID:25103240]"}
{"concept_id": "C3894295", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of meiotic DNA double-strand break formation"}
{"concept_id": "C3894296", "aliases": ["up-regulation of meiotic DNA double-strand break formation", "upregulation of meiotic DNA double-strand break formation", "up regulation of meiotic DNA double-strand break formation"], "types": ["T044"], "canonical_name": "positive regulation of meiotic DNA double-strand break formation", "definition": "Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation. [GO_REF:0000058, GOC:TermGenie, PMID:25103240]"}
{"concept_id": "C3894297", "aliases": [], "types": ["T044"], "canonical_name": "activation of meiotic DNA double-strand break formation"}
{"concept_id": "C3894298", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein polyglycylation", "definition": "Any process that modulates the frequency, rate or extent of protein polyglycylation. [GO_REF:0000058, GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3894299", "aliases": ["down regulation of protein polyglycylation", "down-regulation of protein polyglycylation", "downregulation of protein polyglycylation"], "types": ["T044"], "canonical_name": "negative regulation of protein polyglycylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyglycylation. [GO_REF:0000058, GOC:sart, GOC:TermGenie]"}
{"concept_id": "C3894300", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein polyglycylation"}
{"concept_id": "C3894301", "aliases": ["up regulation of protein polyglycylation", "up-regulation of protein polyglycylation", "upregulation of protein polyglycylation"], "types": ["T044"], "canonical_name": "positive regulation of protein polyglycylation", "definition": "Any process that activates or increases the frequency, rate or extent of protein polyglycylation. [GO_REF:0000058, GOC:sart, GOC:TermGenie, PMID:21298005]"}
{"concept_id": "C3894302", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein polyglycylation"}
{"concept_id": "C3894303", "aliases": ["downregulation of tight junction formation", "down-regulation of tight junction assembly", "down-regulation of tight junction formation", "negative regulation of tight junction formation", "downregulation of tight junction assembly", "down regulation of tight junction formation", "down regulation of tight junction assembly"], "types": ["T043"], "canonical_name": "negative regulation of bicellular tight junction assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly. [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]"}
{"concept_id": "C3894304", "aliases": ["inhibition of tight junction formation"], "types": ["T043"], "canonical_name": "inhibition of tight junction assembly"}
{"concept_id": "C3894305", "aliases": ["up regulation of tight junction formation", "up-regulation of tight junction assembly", "positive regulation of tight junction formation", "upregulation of tight junction formation", "up-regulation of tight junction formation", "up regulation of tight junction assembly", "upregulation of tight junction assembly"], "types": ["T043"], "canonical_name": "positive regulation of bicellular tight junction assembly", "definition": "Any process that activates or increases the frequency, rate or extent of tight junction assembly. [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]"}
{"concept_id": "C3894306", "aliases": ["activation of tight junction formation"], "types": ["T043"], "canonical_name": "activation of tight junction assembly"}
{"concept_id": "C3894307", "aliases": [], "types": ["T026"], "canonical_name": "omegasome membrane", "definition": "Any membrane that is part of an omegasome. [GO_REF:0000064, GOC:mf, GOC:TermGenie, PMID:18725538, PMID:24591649]"}
{"concept_id": "C3894308", "aliases": [], "types": ["T043"], "canonical_name": "response to dopamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]"}
{"concept_id": "C3894309", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to dopamine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]"}
{"concept_id": "C3894310", "aliases": [], "types": ["T043"], "canonical_name": "L-ornithine transmembrane transport", "definition": "The directed movement of L-ornithine across a membrane. [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]"}
{"concept_id": "C3894311", "aliases": ["regulation of nuclear organization", "regulation of nuclear organisation"], "types": ["T043"], "canonical_name": "regulation of nucleus organization", "definition": "Any process that modulates the frequency, rate or extent of nucleus organization. [GO_REF:0000058, GOC:TermGenie, PMID:16943282]"}
{"concept_id": "C3894312", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nuclear morphology"}
{"concept_id": "C3894313", "aliases": ["regulation of nucleus organization and biogenesis"], "types": ["T043"], "canonical_name": "regulation of nuclear organization and biogenesis"}
{"concept_id": "C3894314", "aliases": [], "types": ["T043"], "canonical_name": "regulation of distal tip cell migration", "definition": "Any process that modulates the frequency, rate or extent of distal tip cell migration. [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003]"}
{"concept_id": "C3894315", "aliases": ["down-regulation of distal tip cell migration", "down regulation of distal tip cell migration", "downregulation of distal tip cell migration"], "types": ["T043"], "canonical_name": "negative regulation of distal tip cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of distal tip cell migration. [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003]"}
{"concept_id": "C3894316", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of distal tip cell migration"}
{"concept_id": "C3894317", "aliases": ["up-regulation of distal tip cell migration", "upregulation of distal tip cell migration", "up regulation of distal tip cell migration"], "types": ["T043"], "canonical_name": "positive regulation of distal tip cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of distal tip cell migration. [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003]"}
{"concept_id": "C3894318", "aliases": [], "types": ["T043"], "canonical_name": "activation of distal tip cell migration"}
{"concept_id": "C3894319", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript"}
{"concept_id": "C3894320", "aliases": ["regulation of Golgi organisation"], "types": ["T043"], "canonical_name": "regulation of Golgi organization", "definition": "Any process that modulates the frequency, rate or extent of Golgi organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]"}
{"concept_id": "C3894321", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Golgi organization and biogenesis"}
{"concept_id": "C3894322", "aliases": ["Skb1-containing cortical node assembly", "lateral cortical node formation", "Skb1-containing cortical node formation"], "types": ["T044"], "canonical_name": "lateral cortical node assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a lateral cortical node. [GO_REF:0000079, GOC:TermGenie, PMID:25009287]"}
{"concept_id": "C3894323", "aliases": ["protein localisation to lateral cortical node", "protein localisation in lateral cortical node", "protein localization in lateral cortical node"], "types": ["T043"], "canonical_name": "protein localization to lateral cortical node", "definition": "A process in which a protein is transported to, or maintained in, a location within a lateral cortical node. [GO_REF:0000087, GOC:TermGenie, PMID:25009287]"}
{"concept_id": "C3894324", "aliases": ["basolateral protein localization", "protein localization in basolateral plasma membrane", "protein localisation in basolateral plasma membrane", "protein localisation to basolateral plasma membrane"], "types": ["T043"], "canonical_name": "protein localization to basolateral plasma membrane", "definition": "Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]"}
{"concept_id": "C3894330", "aliases": ["regulation of physiological fear response"], "types": ["T038"], "canonical_name": "regulation of fear response", "definition": "Any process that modulates the frequency, rate or extent of fear response. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]"}
{"concept_id": "C3894331", "aliases": ["negative regulation of physiological fear response", "down-regulation of fear response", "down regulation of fear response", "downregulation of fear response", "downregulation of physiological fear response", "down regulation of physiological fear response", "down-regulation of physiological fear response"], "types": ["T039"], "canonical_name": "negative regulation of fear response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fear response. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]"}
{"concept_id": "C3894332", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of fear response"}
{"concept_id": "C3894333", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of physiological fear response"}
{"concept_id": "C3894334", "aliases": ["up regulation of fear response", "up-regulation of fear response", "upregulation of fear response", "positive regulation of physiological fear response", "upregulation of physiological fear response", "up-regulation of physiological fear response", "up regulation of physiological fear response"], "types": ["T039"], "canonical_name": "positive regulation of fear response", "definition": "Any process that activates or increases the frequency, rate or extent of fear response. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]"}
{"concept_id": "C3894335", "aliases": [], "types": ["T039"], "canonical_name": "activation of fear response"}
{"concept_id": "C3894336", "aliases": [], "types": ["T039"], "canonical_name": "activation of physiological fear response"}
{"concept_id": "C3894337", "aliases": [], "types": ["T055"], "canonical_name": "regulation of foraging behavior", "definition": "Any process that modulates the frequency, rate or extent of foraging behavior. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]"}
{"concept_id": "C3894338", "aliases": ["down-regulation of foraging behavior", "downregulation of foraging behavior", "down regulation of foraging behavior"], "types": ["T040"], "canonical_name": "negative regulation of foraging behavior", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of foraging behavior. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]"}
{"concept_id": "C3894339", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of foraging behavior"}
{"concept_id": "C3894340", "aliases": ["up regulation of foraging behavior", "upregulation of foraging behavior", "up-regulation of foraging behavior"], "types": ["T040"], "canonical_name": "positive regulation of foraging behavior", "definition": "Any process that activates or increases the frequency, rate or extent of foraging behavior. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]"}
{"concept_id": "C3894341", "aliases": [], "types": ["T040"], "canonical_name": "activation of foraging behavior"}
{"concept_id": "C3894342", "aliases": ["regulation of endoplasmic reticulum tubular network organisation", "regulation of ER tubular network organisation", "regulation of ER tubular network organization"], "types": ["T043"], "canonical_name": "regulation of endoplasmic reticulum tubular network organization", "definition": "Any process that modulates the frequency, rate or extent of endoplasmic reticulum tubular network organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]"}
{"concept_id": "C3894343", "aliases": ["down-regulation of endoplasmic reticulum tubular network organization", "negative regulation of endoplasmic reticulum tubular network organisation", "down-regulation of ER tubular network organisation", "down-regulation of ER tubular network organization", "downregulation of ER tubular network organization", "down-regulation of endoplasmic reticulum tubular network organisation", "down regulation of endoplasmic reticulum tubular network organization", "inhibition of endoplasmic reticulum tubular network organization", "negative regulation of ER tubular network organisation", "inhibition of endoplasmic reticulum tubular network organisation", "negative regulation of ER tubular network organization", "down regulation of endoplasmic reticulum tubular network organisation", "down regulation of ER tubular network organisation", "down regulation of ER tubular network organization", "downregulation of endoplasmic reticulum tubular network organisation", "downregulation of endoplasmic reticulum tubular network organization", "downregulation of ER tubular network organisation"], "types": ["T043"], "canonical_name": "negative regulation of endoplasmic reticulum tubular network organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum tubular network organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]"}
{"concept_id": "C3894344", "aliases": ["inhibition of ER tubular network organization"], "types": ["T043"], "canonical_name": "inhibition of ER tubular network organisation"}
{"concept_id": "C3894345", "aliases": ["up regulation of endoplasmic reticulum tubular network organisation", "up regulation of endoplasmic reticulum tubular network organization", "upregulation of ER tubular network organization", "up-regulation of ER tubular network organization", "positive regulation of ER tubular network organisation", "up regulation of ER tubular network organisation", "up-regulation of endoplasmic reticulum tubular network organisation", "up-regulation of endoplasmic reticulum tubular network organization", "positive regulation of ER tubular network organization", "upregulation of endoplasmic reticulum tubular network organisation", "up regulation of ER tubular network organization", "positive regulation of endoplasmic reticulum tubular network organisation", "up-regulation of ER tubular network organisation", "upregulation of ER tubular network organisation", "upregulation of endoplasmic reticulum tubular network organization"], "types": ["T043"], "canonical_name": "positive regulation of endoplasmic reticulum tubular network organization", "definition": "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum tubular network organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]"}
{"concept_id": "C3894346", "aliases": ["activation of endoplasmic reticulum tubular network organization"], "types": ["T043"], "canonical_name": "activation of endoplasmic reticulum tubular network organisation"}
{"concept_id": "C3894347", "aliases": ["activation of ER tubular network organization"], "types": ["T043"], "canonical_name": "activation of ER tubular network organisation"}
{"concept_id": "C3894354", "aliases": ["facio-acoustic ganglion development", "acousticofacial ganglion development", "facio-acoustic VII-VIII ganglion complex development", "acoustico-facial VII-VIII ganglion complex development", "facio-acoustic ganglion complex VII-VIII development"], "types": ["T042"], "canonical_name": "facioacoustic ganglion development", "definition": "The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure. [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247]"}
{"concept_id": "C3894355", "aliases": ["regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress"], "types": ["T043"], "canonical_name": "regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894356", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neuron apoptosis in response to oxidative stress"}
{"concept_id": "C3894357", "aliases": ["regulation of oxidative stress-induced neuronal apoptosis"], "types": ["T043"], "canonical_name": "regulation of oxidative stress-induced neuron apoptosis"}
{"concept_id": "C3894358", "aliases": ["down-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "down regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "negative regulation of oxidative stress-induced neuron apoptosis", "negative regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "downregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress"], "types": ["T043"], "canonical_name": "negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595]"}
{"concept_id": "C3894359", "aliases": ["negative regulation of neuron apoptosis in response to oxidative stress", "downregulation of neuron apoptosis in response to oxidative stress", "down-regulation of neuron apoptosis in response to oxidative stress"], "types": ["T043"], "canonical_name": "down regulation of neuron apoptosis in response to oxidative stress"}
{"concept_id": "C3894360", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuron apoptosis in response to oxidative stress"}
{"concept_id": "C3894361", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuron intrinsic apoptotic signaling pathway in response to oxidative stress"}
{"concept_id": "C3894362", "aliases": [], "types": ["T043"], "canonical_name": "neuroprotection against oxidative stress-induced apoptosis"}
{"concept_id": "C3894363", "aliases": ["protection against oxidative stress-induced neuronal apoptosis"], "types": ["T043"], "canonical_name": "protection against oxidative stress-induced neuron apoptosis"}
{"concept_id": "C3894364", "aliases": ["positive regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "up-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "up regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "upregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress"], "types": ["T043"], "canonical_name": "positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894365", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuron apoptosis in response to oxidative stress"}
{"concept_id": "C3894366", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress"}
{"concept_id": "C3894367", "aliases": ["upregulation of neuron apoptosis in response to oxidative stress", "up regulation of neuron apoptosis in response to oxidative stress", "up-regulation of neuron apoptosis in response to oxidative stress"], "types": ["T043"], "canonical_name": "positive regulation of neuron apoptosis in response to oxidative stress"}
{"concept_id": "C3894368", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic chromosome condensation", "definition": "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation. [GO_REF:0000058, GOC:TermGenie, PMID:9490640]"}
{"concept_id": "C3894369", "aliases": ["upregulation of mitotic chromosome condensation", "up regulation of mitotic chromosome condensation", "up-regulation of mitotic chromosome condensation"], "types": ["T043"], "canonical_name": "positive regulation of mitotic chromosome condensation", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation. [GO_REF:0000058, GOC:TermGenie, PMID:9490640]"}
{"concept_id": "C3894370", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic chromosome condensation"}
{"concept_id": "C3894371", "aliases": ["regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway", "regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"], "types": ["T043"], "canonical_name": "regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894372", "aliases": ["regulation of endoplasmic reticulum stress-induced neuron apoptosis"], "types": ["T043"], "canonical_name": "regulation of ER stress-induced neuron apoptosis"}
{"concept_id": "C3894373", "aliases": ["down-regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway", "negative regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "down regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway", "down regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "downregulation of ER stress-induced neuron intrinsic apoptotic signaling pathway", "downregulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway", "down-regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway", "down-regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "downregulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "negative regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway", "down regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807]"}
{"concept_id": "C3894374", "aliases": ["inhibition of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "inhibition of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "inhibition of ER stress-induced neuron intrinsic apoptotic signaling pathway"}
{"concept_id": "C3894375", "aliases": ["regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway", "regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2"], "types": ["T043"], "canonical_name": "regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894376", "aliases": ["regulation of hydrogen peroxide-induced neuron apoptosis"], "types": ["T043"], "canonical_name": "regulation of H2O2-induced neuron apoptosis"}
{"concept_id": "C3894377", "aliases": ["regulation of neuron apoptosis in response to hydrogen peroxide"], "types": ["T043"], "canonical_name": "regulation of hydrogen peroxide-induced neuronal apoptosis"}
{"concept_id": "C3894378", "aliases": ["down regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "downregulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "down regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway", "downregulation of H2O2-induced neuron intrinsic apoptotic signaling pathway", "down-regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "downregulation of neuron intrinsic apoptotic signaling pathway in response to H2O2", "negative regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2", "down regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2", "negative regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "down-regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway", "negative regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway", "down-regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2"], "types": ["T043"], "canonical_name": "negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23261939]"}
{"concept_id": "C3894379", "aliases": ["downregulation of neuron apoptosis in response to hydrogen peroxide", "down-regulation of neuron apoptosis in response to hydrogen peroxide"], "types": ["T043"], "canonical_name": "down regulation of neuron apoptosis in response to hydrogen peroxide"}
{"concept_id": "C3894380", "aliases": ["inhibition of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "inhibition of neuron intrinsic apoptotic signaling pathway in response to H2O2"], "types": ["T043"], "canonical_name": "inhibition of H2O2-induced neuron intrinsic apoptotic signaling pathway"}
{"concept_id": "C3894381", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuron apoptosis in response to hydrogen peroxide"}
{"concept_id": "C3894382", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of neuron apoptosis in response to hydrogen peroxide"}
{"concept_id": "C3894383", "aliases": ["protection against hydrogen peroxide-induced neuron apoptosis"], "types": ["T043"], "canonical_name": "protection against H2O2-induced neuron apoptosis"}
{"concept_id": "C3894384", "aliases": [], "types": ["T043"], "canonical_name": "regulation of homophilic cell adhesion", "definition": "Any process that modulates the frequency, rate or extent of homophilic cell adhesion. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]"}
{"concept_id": "C3894385", "aliases": ["down regulation of homophilic cell adhesion", "downregulation of homophilic cell adhesion", "down-regulation of homophilic cell adhesion"], "types": ["T043"], "canonical_name": "negative regulation of homophilic cell adhesion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of homophilic cell adhesion. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]"}
{"concept_id": "C3894386", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of homophilic cell adhesion"}
{"concept_id": "C3894387", "aliases": ["up regulation of homophilic cell adhesion", "upregulation of homophilic cell adhesion", "up-regulation of homophilic cell adhesion"], "types": ["T043"], "canonical_name": "positive regulation of homophilic cell adhesion", "definition": "Any process that activates or increases the frequency, rate or extent of homophilic cell adhesion. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]"}
{"concept_id": "C3894388", "aliases": [], "types": ["T043"], "canonical_name": "activation of homophilic cell adhesion"}
{"concept_id": "C3894389", "aliases": ["regulation of synaptic vesicle coat protein depolymerization", "regulation of synaptic vesicle coat depolymerization"], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle uncoating", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle uncoating. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316]"}
{"concept_id": "C3894390", "aliases": ["downregulation of synaptic vesicle uncoating", "downregulation of synaptic vesicle coat protein depolymerization", "negative regulation of synaptic vesicle coat protein depolymerization", "downregulation of synaptic vesicle coat depolymerization", "down-regulation of synaptic vesicle coat protein depolymerization", "down-regulation of synaptic vesicle coat depolymerization", "down regulation of synaptic vesicle coat depolymerization", "down-regulation of synaptic vesicle uncoating", "down regulation of synaptic vesicle coat protein depolymerization", "negative regulation of synaptic vesicle coat depolymerization", "down regulation of synaptic vesicle uncoating"], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle uncoating", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle uncoating. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316]"}
{"concept_id": "C3894391", "aliases": ["inhibition of synaptic vesicle coat protein depolymerization", "inhibition of synaptic vesicle uncoating"], "types": ["T043"], "canonical_name": "inhibition of synaptic vesicle coat depolymerization"}
{"concept_id": "C3894392", "aliases": ["positive regulation of synaptic vesicle coat depolymerization", "up regulation of synaptic vesicle uncoating", "up regulation of synaptic vesicle coat protein depolymerization", "up-regulation of synaptic vesicle uncoating", "upregulation of synaptic vesicle coat protein depolymerization", "upregulation of synaptic vesicle coat depolymerization", "up-regulation of synaptic vesicle coat depolymerization", "positive regulation of synaptic vesicle coat protein depolymerization", "upregulation of synaptic vesicle uncoating", "up-regulation of synaptic vesicle coat protein depolymerization", "up regulation of synaptic vesicle coat depolymerization"], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle uncoating", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle uncoating. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316]"}
{"concept_id": "C3894393", "aliases": ["activation of synaptic vesicle coat protein depolymerization", "activation of synaptic vesicle uncoating"], "types": ["T043"], "canonical_name": "activation of synaptic vesicle coat depolymerization"}
{"concept_id": "C3894394", "aliases": ["regulation of adherens junction organisation", "regulation of adherens junction assembly and maintenance"], "types": ["T043"], "canonical_name": "regulation of adherens junction organization", "definition": "Any process that modulates the frequency, rate or extent of adherens junction organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]"}
{"concept_id": "C3894395", "aliases": ["down-regulation of adherens junction assembly and maintenance", "down-regulation of adherens junction organization", "downregulation of adherens junction organization", "down regulation of adherens junction organization", "negative regulation of adherens junction assembly and maintenance", "down-regulation of adherens junction organisation", "down regulation of adherens junction organisation", "negative regulation of adherens junction organisation", "downregulation of adherens junction assembly and maintenance", "down regulation of adherens junction assembly and maintenance", "downregulation of adherens junction organisation"], "types": ["T043"], "canonical_name": "negative regulation of adherens junction organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]"}
{"concept_id": "C3894396", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adherens junction assembly and maintenance"}
{"concept_id": "C3894397", "aliases": ["inhibition of adherens junction organization"], "types": ["T043"], "canonical_name": "inhibition of adherens junction organisation"}
{"concept_id": "C3894398", "aliases": ["up-regulation of adherens junction organization", "up-regulation of adherens junction organisation", "up regulation of adherens junction organization", "upregulation of adherens junction organisation", "positive regulation of adherens junction organisation", "upregulation of adherens junction assembly and maintenance", "positive regulation of adherens junction assembly and maintenance", "upregulation of adherens junction organization", "up-regulation of adherens junction assembly and maintenance", "up regulation of adherens junction assembly and maintenance", "up regulation of adherens junction organisation"], "types": ["T043"], "canonical_name": "positive regulation of adherens junction organization", "definition": "Any process that activates or increases the frequency, rate or extent of adherens junction organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]"}
{"concept_id": "C3894399", "aliases": [], "types": ["T043"], "canonical_name": "activation of adherens junction assembly and maintenance"}
{"concept_id": "C3894400", "aliases": ["activation of adherens junction organization"], "types": ["T043"], "canonical_name": "activation of adherens junction organisation"}
{"concept_id": "C3894401", "aliases": ["protein localisation to kinetochore involved in kinetochore assembly"], "types": ["T043"], "canonical_name": "protein localization to kinetochore involved in kinetochore assembly", "definition": "Any protein localization to kinetochore that is involved in kinetochore assembly. [GO_REF:0000060, GOC:TermGenie, PMID:15369671]"}
{"concept_id": "C3894402", "aliases": ["condensin localization to kinetochore involved in centromere/kinetochore complex maturation"], "types": ["T043"], "canonical_name": "condensin localization to kinetochore involved in centromere and kinetochore complex maturation"}
{"concept_id": "C3894403", "aliases": [], "types": ["T043"], "canonical_name": "condensin localization to kinetochore involved in chromosome-kinetochore attachment"}
{"concept_id": "C3894404", "aliases": ["condensin localization to kinetochore involved in kinetochore formation"], "types": ["T043"], "canonical_name": "condensin localization to kinetochore involved in kinetochore assembly"}
{"concept_id": "C3894405", "aliases": ["protein localization to kinetochore involved in centromere and kinetochore complex maturation", "protein localization to kinetochore involved in centromere/kinetochore complex maturation", "protein localisation to kinetochore involved in centromere/kinetochore complex maturation"], "types": ["T043"], "canonical_name": "protein localisation to kinetochore involved in centromere and kinetochore complex maturation"}
{"concept_id": "C3894406", "aliases": ["protein localization to kinetochore involved in chromosome-kinetochore attachment"], "types": ["T043"], "canonical_name": "protein localisation to kinetochore involved in chromosome-kinetochore attachment"}
{"concept_id": "C3894407", "aliases": ["protein localization to kinetochore involved in kinetochore formation"], "types": ["T043"], "canonical_name": "protein localisation to kinetochore involved in kinetochore formation"}
{"concept_id": "C3894408", "aliases": [], "types": ["T043"], "canonical_name": "regulation of secondary cell septum biogenesis", "definition": "Any process that modulates the frequency, rate or extent of secondary cell septum biogenesis. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277]"}
{"concept_id": "C3894409", "aliases": ["down-regulation of secondary cell septum biogenesis", "downregulation of secondary cell septum biogenesis", "down regulation of secondary cell septum biogenesis"], "types": ["T043"], "canonical_name": "negative regulation of secondary cell septum biogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell septum biogenesis. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277]"}
{"concept_id": "C3894410", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of secondary cell septum biogenesis"}
{"concept_id": "C3894411", "aliases": ["up regulation of secondary cell septum biogenesis", "upregulation of secondary cell septum biogenesis", "up-regulation of secondary cell septum biogenesis"], "types": ["T043"], "canonical_name": "positive regulation of secondary cell septum biogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of secondary cell septum biogenesis. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277]"}
{"concept_id": "C3894412", "aliases": [], "types": ["T043"], "canonical_name": "activation of secondary cell septum biogenesis"}
{"concept_id": "C3894413", "aliases": ["regulation of M(7)G(5')pppN pyrophosphatase activity", "regulation of m7G(5')pppN pyrophosphatase activity", "regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity"], "types": ["T044"], "canonical_name": "regulation of m7G(5')pppN diphosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of m7G(5')pppN diphosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:22323607]"}
{"concept_id": "C3894414", "aliases": [], "types": ["T044"], "canonical_name": "regulation of decapase activity"}
{"concept_id": "C3894415", "aliases": ["positive regulation of M(7)G(5')pppN pyrophosphatase activity", "up-regulation of m7G(5')pppN diphosphatase activity", "positive regulation of m7G(5')pppN pyrophosphatase activity", "upregulation of M(7)G(5')pppN pyrophosphatase activity", "up regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity", "up regulation of M(7)G(5')pppN pyrophosphatase activity", "up-regulation of M(7)G(5')pppN pyrophosphatase activity", "upregulation of m7G(5')pppN pyrophosphatase activity", "up regulation of m7G(5')pppN diphosphatase activity", "up-regulation of m7G(5')pppN pyrophosphatase activity", "positive regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity", "upregulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity", "up regulation of m7G(5')pppN pyrophosphatase activity", "up-regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity", "upregulation of m7G(5')pppN diphosphatase activity"], "types": ["T044"], "canonical_name": "positive regulation of m7G(5')pppN diphosphatase activity", "definition": "Any process that activates or increases the frequency, rate or extent of m7G(5')pppN diphosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:22323607]"}
{"concept_id": "C3894416", "aliases": ["activation of m7G(5')pppN diphosphatase activity", "activation of M(7)G(5')pppN pyrophosphatase activity", "activation of m7G(5')pppN pyrophosphatase activity"], "types": ["T044"], "canonical_name": "activation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity"}
{"concept_id": "C3894417", "aliases": [], "types": ["T044"], "canonical_name": "activation of decapase activity"}
{"concept_id": "C3894418", "aliases": ["up-regulation of decapase activity", "up regulation of decapase activity"], "types": ["T044"], "canonical_name": "positive regulation of decapase activity"}
{"concept_id": "C3894419", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of decapase activity"}
{"concept_id": "C3894421", "aliases": [], "types": ["T044"], "canonical_name": "L-lysine transmembrane transport", "definition": "The directed movement of L-lysine across a membrane. [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]"}
{"concept_id": "C3894422", "aliases": ["regulation of renal phosphate ion excretion"], "types": ["T038"], "canonical_name": "regulation of renal phosphate excretion", "definition": "Any process that modulates the frequency, rate or extent of renal phosphate excretion. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837]"}
{"concept_id": "C3894423", "aliases": ["downregulation of renal phosphate ion excretion", "down regulation of renal phosphate excretion", "down regulation of renal phosphate ion excretion", "down-regulation of renal phosphate excretion", "negative regulation of renal phosphate ion excretion", "inhibition of renal phosphate ion excretion", "downregulation of renal phosphate excretion", "down-regulation of renal phosphate ion excretion", "inhibition of renal phosphate excretion"], "types": ["T039"], "canonical_name": "negative regulation of renal phosphate excretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of renal phosphate excretion. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837]"}
{"concept_id": "C3894424", "aliases": ["up-regulation of renal phosphate excretion", "activation of renal phosphate ion excretion", "upregulation of renal phosphate ion excretion", "up regulation of renal phosphate ion excretion", "positive regulation of renal phosphate ion excretion", "activation of renal phosphate excretion", "upregulation of renal phosphate excretion", "up regulation of renal phosphate excretion", "up-regulation of renal phosphate ion excretion"], "types": ["T039"], "canonical_name": "positive regulation of renal phosphate excretion", "definition": "Any process that activates or increases the frequency, rate or extent of renal phosphate excretion. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837]"}
{"concept_id": "C3894425", "aliases": ["protein localisation to nuclear body", "protein localisation in nuclear body", "protein localization in nuclear body"], "types": ["T043"], "canonical_name": "protein localization to nuclear body", "definition": "A process in which a protein is transported to, or maintained in, a location within a nuclear body. [GO_REF:0000087, GOC:TermGenie, PMID:24713849]"}
{"concept_id": "C3894426", "aliases": ["regulation of (Na+ + K+)-activated ATPase activity", "regulation of sodium:potassium-exchanging ATPase activity", "regulation of ATP phosphohydrolase (Na+/K+-exchanging)", "regulation of Na+/K+-ATPase activity", "regulation of sodium pump", "regulation of sodium:potassium exchanging ATPase activity", "regulation of Na(+)/K(+)-ATPase activity", "regulation of Na,K-activated ATPase activity", "regulation of Na(+)/K(+)-exchanging ATPase activity", "regulation of Na+/K+-exchanging ATPase activity", "regulation of sodium/potassium-transporting ATPase activity", "regulation of Na+,K+-ATPase activity", "regulation of sodium/potassium-exchanging ATPase activity", "regulation of (Na+ + K+)-ATPase activity"], "types": ["T044"], "canonical_name": "regulation of P-type sodium:potassium-exchanging transporter activity", "definition": "Any process that modulates the frequency, rate or extent of sodium:potassium-exchanging ATPase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]"}
{"concept_id": "C3894427", "aliases": ["regulation of Na,K-pump"], "types": ["T044"], "canonical_name": "regulation of Na+,K+ pump"}
{"concept_id": "C3894428", "aliases": ["inhibition of Na+/K+-ATPase activity", "down-regulation of Na(+)/K(+)-ATPase activity", "down-regulation of sodium:potassium exchanging ATPase activity", "down-regulation of Na(+)/K(+)-exchanging ATPase activity", "down-regulation of Na+/K+-exchanging ATPase activity", "inhibition of sodium/potassium-exchanging ATPase activity", "downregulation of Na+/K+-ATPase activity", "down regulation of Na,K-activated ATPase activity", "negative regulation of sodium/potassium-exchanging ATPase activity", "inhibition of sodium:potassium exchanging ATPase activity", "negative regulation of Na+/K+-ATPase activity", "downregulation of Na(+)/K(+)-ATPase activity", "downregulation of ATP phosphohydrolase (Na+/K+-exchanging)", "downregulation of Na(+)/K(+)-exchanging ATPase activity", "down-regulation of sodium:potassium-exchanging ATPase activity", "down regulation of sodium/potassium-exchanging ATPase activity", "downregulation of sodium:potassium-exchanging ATPase activity", "down regulation of ATP phosphohydrolase (Na+/K+-exchanging)", "inhibition of Na,K-activated ATPase activity", "downregulation of (Na+ + K+)-activated ATPase activity", "inhibition of Na+,K+-ATPase activity", "down-regulation of Na+,K+-ATPase activity", "negative regulation of Na+/K+-exchanging ATPase activity", "down-regulation of sodium/potassium-exchanging ATPase activity", "negative regulation of (Na+ + K+)-activated ATPase activity", "down-regulation of Na+/K+-ATPase activity", "down-regulation of Na,K-activated ATPase activity", "down regulation of sodium:potassium exchanging ATPase activity", "downregulation of sodium/potassium-exchanging ATPase activity", "downregulation of sodium/potassium-transporting ATPase activity", "down-regulation of (Na+ + K+)-activated ATPase activity", "down regulation of Na(+)/K(+)-ATPase activity", "negative regulation of Na(+)/K(+)-exchanging ATPase activity", "down regulation of Na+/K+-exchanging ATPase activity", "downregulation of Na,K-activated ATPase activity", "downregulation of sodium:potassium exchanging ATPase activity", "negative regulation of Na+,K+-ATPase activity", "downregulation of (Na+ + K+)-ATPase activity", "downregulation of Na+/K+-exchanging ATPase activity", "negative regulation of sodium:potassium exchanging ATPase activity", "inhibition of Na(+)/K(+)-ATPase activity", "inhibition of (Na+ + K+)-ATPase activity", "negative regulation of Na,K-activated ATPase activity", "negative regulation of ATP phosphohydrolase (Na+/K+-exchanging)", "negative regulation of sodium/potassium-transporting ATPase activity", "down regulation of (Na+ + K+)-ATPase activity", "inhibition of (Na+ + K+)-activated ATPase activity", "down regulation of sodium:potassium-exchanging ATPase activity", "down-regulation of (Na+ + K+)-ATPase activity", "negative regulation of (Na+ + K+)-ATPase activity", "negative regulation of Na(+)/K(+)-ATPase activity", "down regulation of (Na+ + K+)-activated ATPase activity", "down regulation of Na+,K+-ATPase activity", "inhibition of sodium:potassium-exchanging ATPase activity", "downregulation of Na+,K+-ATPase activity", "down regulation of Na+/K+-ATPase activity", "down-regulation of ATP phosphohydrolase (Na+/K+-exchanging)", "down regulation of sodium/potassium-transporting ATPase activity", "down regulation of Na(+)/K(+)-exchanging ATPase activity", "down-regulation of sodium/potassium-transporting ATPase activity", "negative regulation of sodium:potassium-exchanging ATPase activity"], "types": ["T044"], "canonical_name": "negative regulation of P-type sodium:potassium-exchanging transporter activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sodium:potassium-exchanging ATPase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]"}
{"concept_id": "C3894429", "aliases": ["down-regulation of Na,K-pump", "down regulation of Na,K-pump", "down-regulation of Na+,K+ pump"], "types": ["T044"], "canonical_name": "down regulation of Na+,K+ pump"}
{"concept_id": "C3894430", "aliases": ["downregulation of Na,K-pump"], "types": ["T044"], "canonical_name": "downregulation of Na+,K+ pump"}
{"concept_id": "C3894431", "aliases": ["inhibition of sodium/potassium-transporting ATPase activity"], "types": ["T044"], "canonical_name": "inhibition of ATP phosphohydrolase (Na+/K+-exchanging)"}
{"concept_id": "C3894432", "aliases": ["inhibition of Na+/K+-exchanging ATPase activity"], "types": ["T044"], "canonical_name": "inhibition of Na(+)/K(+)-exchanging ATPase activity"}
{"concept_id": "C3894433", "aliases": ["inhibition of Na,K-pump"], "types": ["T044"], "canonical_name": "inhibition of Na+,K+ pump"}
{"concept_id": "C3894434", "aliases": ["negative regulation of Na,K-pump"], "types": ["T044"], "canonical_name": "negative regulation of Na+,K+ pump"}
{"concept_id": "C3894435", "aliases": ["upregulation of sodium:potassium exchanging ATPase activity", "upregulation of sodium/potassium-exchanging ATPase activity", "upregulation of sodium:potassium-exchanging ATPase activity", "up regulation of Na(+)/K(+)-ATPase activity", "up-regulation of (Na+ + K+)-activated ATPase activity", "up-regulation of Na+,K+-ATPase activity", "up-regulation of Na+/K+-exchanging ATPase activity", "up regulation of sodium/potassium-exchanging ATPase activity", "up regulation of sodium:potassium-exchanging ATPase activity", "up-regulation of Na+/K+-ATPase activity", "upregulation of (Na+ + K+)-activated ATPase activity", "upregulation of Na(+)/K(+)-ATPase activity", "up regulation of Na+,K+-ATPase activity", "upregulation of Na(+)/K(+)-exchanging ATPase activity", "up regulation of Na+/K+-ATPase activity", "positive regulation of Na(+)/K(+)-ATPase activity", "up regulation of (Na+ + K+)-ATPase activity", "up-regulation of Na(+)/K(+)-ATPase activity", "upregulation of ATP phosphohydrolase (Na+/K+-exchanging)", "up regulation of Na+/K+-exchanging ATPase activity", "upregulation of Na+/K+-ATPase activity", "positive regulation of ATP phosphohydrolase (Na+/K+-exchanging)", "up-regulation of Na(+)/K(+)-exchanging ATPase activity", "up regulation of sodium:potassium exchanging ATPase activity", "up regulation of Na(+)/K(+)-exchanging ATPase activity", "up-regulation of sodium/potassium-exchanging ATPase activity", "up regulation of ATP phosphohydrolase (Na+/K+-exchanging)", "upregulation of (Na+ + K+)-ATPase activity", "positive regulation of sodium/potassium-transporting ATPase activity", "positive regulation of sodium/potassium-exchanging ATPase activity", "upregulation of Na+,K+-ATPase activity", "up-regulation of sodium:potassium exchanging ATPase activity", "upregulation of sodium/potassium-transporting ATPase activity", "positive regulation of (Na+ + K+)-activated ATPase activity", "activation of ATP phosphohydrolase (Na+/K+-exchanging)", "upregulation of Na+/K+-exchanging ATPase activity", "up regulation of Na,K-activated ATPase activity", "positive regulation of Na(+)/K(+)-exchanging ATPase activity", "up-regulation of sodium/potassium-transporting ATPase activity", "positive regulation of Na,K-activated ATPase activity", "activation of sodium/potassium-transporting ATPase activity", "up-regulation of sodium:potassium-exchanging ATPase activity", "up regulation of sodium/potassium-transporting ATPase activity", "up-regulation of (Na+ + K+)-ATPase activity", "positive regulation of Na+/K+-exchanging ATPase activity", "positive regulation of (Na+ + K+)-ATPase activity", "upregulation of Na,K-activated ATPase activity", "positive regulation of Na+,K+-ATPase activity", "positive regulation of sodium:potassium-exchanging ATPase activity", "up regulation of (Na+ + K+)-activated ATPase activity", "up-regulation of Na,K-activated ATPase activity", "positive regulation of Na+/K+-ATPase activity", "up-regulation of ATP phosphohydrolase (Na+/K+-exchanging)", "positive regulation of sodium:potassium exchanging ATPase activity"], "types": ["T044"], "canonical_name": "positive regulation of P-type sodium:potassium-exchanging transporter activity", "definition": "Any process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]"}
{"concept_id": "C3894436", "aliases": ["activation of Na,K-activated ATPase activity"], "types": ["T044"], "canonical_name": "activation of (Na+ + K+)-activated ATPase activity"}
{"concept_id": "C3894437", "aliases": ["activation of Na+/K+-ATPase activity", "activation of Na+,K+ pump", "activation of Na+,K+-ATPase activity", "activation of Na,K-pump", "activation of Na(+)/K(+)-ATPase activity"], "types": ["T044"], "canonical_name": "activation of (Na+ + K+)-ATPase activity"}
{"concept_id": "C3894438", "aliases": ["activation of Na+/K+-exchanging ATPase activity"], "types": ["T044"], "canonical_name": "activation of Na(+)/K(+)-exchanging ATPase activity"}
{"concept_id": "C3894439", "aliases": ["activation of sodium:potassium-exchanging ATPase activity", "activation of sodium:potassium exchanging ATPase activity"], "types": ["T044"], "canonical_name": "activation of sodium/potassium-exchanging ATPase activity"}
{"concept_id": "C3894440", "aliases": ["positive regulation of Na,K-pump"], "types": ["T044"], "canonical_name": "positive regulation of Na+,K+ pump"}
{"concept_id": "C3894441", "aliases": ["up-regulation of Na+,K+ pump", "up-regulation of Na,K-pump", "up regulation of Na,K-pump"], "types": ["T044"], "canonical_name": "up regulation of Na+,K+ pump"}
{"concept_id": "C3894442", "aliases": ["upregulation of Na,K-pump"], "types": ["T044"], "canonical_name": "upregulation of Na+,K+ pump"}
{"concept_id": "C3894443", "aliases": ["ROS generation", "ROS formation", "reactive oxygen species anabolism", "reactive oxygen species generation", "reactive oxygen species biosynthesis", "reactive oxygen species formation", "reactive oxygen species synthesis"], "types": ["T038"], "canonical_name": "reactive oxygen species biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]"}
{"concept_id": "C3894446", "aliases": [], "types": ["T043"], "canonical_name": "response to bile acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]"}
{"concept_id": "C3894447", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to bile acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]"}
{"concept_id": "C3894448", "aliases": [], "types": ["T043"], "canonical_name": "iron cation export"}
{"concept_id": "C3894449", "aliases": ["flavonoid accumulation in vacuole"], "types": ["T043"], "canonical_name": "flavonoid transport from endoplasmic reticulum to plant-type vacuole", "definition": "The directed movement of flavonoid from endoplasmic reticulum to plant-type vacuole. [GO_REF:0000078, GOC:tb, GOC:TermGenie, PMID:25116949]"}
{"concept_id": "C3894450", "aliases": ["cellular response to ouabain"], "types": ["T043"], "canonical_name": "response to glycoside", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus. [GO_REF:0000071, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:12027881, PMID:16243970]"}
{"concept_id": "C3894451", "aliases": ["protein localization in plasma membrane of cell tip", "protein localisation in plasma membrane of cell tip", "protein localisation to plasma membrane of cell tip"], "types": ["T043"], "canonical_name": "protein localization to plasma membrane of cell tip", "definition": "A process in which a protein is transported to, or maintained in, a location within a plasma membrane of cell tip. [GO_REF:0000087, GOC:TermGenie, PMID:25157670, PMID:27852900]"}
{"concept_id": "C3894452", "aliases": ["protein localisation in cortical endoplasmic reticulum", "protein localisation to cortical endoplasmic reticulum", "protein localization in cortical endoplasmic reticulum", "protein localization to cortical ER"], "types": ["T043"], "canonical_name": "protein localization to cortical endoplasmic reticulum", "definition": "A process in which a protein is transported to, or maintained in, a location within a cortical endoplasmic reticulum. [GO_REF:0000087, GOC:TermGenie, PMID:25103238]"}
{"concept_id": "C3894453", "aliases": ["protein localization in endoplasmic reticulum tubular network", "protein localisation in endoplasmic reticulum tubular network", "protein localisation to endoplasmic reticulum tubular network", "protein localization to tubular ER"], "types": ["T043"], "canonical_name": "protein localization to endoplasmic reticulum tubular network", "definition": "A process in which a protein is transported to, or maintained in, a location within an endoplasmic reticulum tubular network. [GO_REF:0000087, GOC:TermGenie, PMID:25103238]"}
{"concept_id": "C3894454", "aliases": ["regulation of kiss-and-stay synaptic vesicle recycling", "regulation of kiss-and-run synaptic vesicle recycling"], "types": ["T042"], "canonical_name": "regulation of synaptic vesicle recycling", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle recycling. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]"}
{"concept_id": "C3894455", "aliases": ["inhibition of synaptic vesicle recycling", "inhibition of kiss-and-stay synaptic vesicle recycling", "negative regulation of kiss-and-stay synaptic vesicle recycling", "down-regulation of synaptic vesicle recycling", "downregulation of kiss-and-run synaptic vesicle recycling", "negative regulation of kiss-and-run synaptic vesicle recycling", "inhibition of kiss-and-run synaptic vesicle recycling", "down regulation of synaptic vesicle recycling", "downregulation of synaptic vesicle recycling", "downregulation of kiss-and-stay synaptic vesicle recycling"], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle recycling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle recycling. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]"}
{"concept_id": "C3894456", "aliases": ["down-regulation of kiss-and-run synaptic vesicle recycling"], "types": ["T043"], "canonical_name": "down regulation of kiss-and-run synaptic vesicle recycling"}
{"concept_id": "C3894457", "aliases": ["down-regulation of kiss-and-stay synaptic vesicle recycling"], "types": ["T043"], "canonical_name": "down regulation of kiss-and-stay synaptic vesicle recycling"}
{"concept_id": "C3894458", "aliases": ["up-regulation of synaptic vesicle recycling", "upregulation of synaptic vesicle recycling", "upregulation of kiss-and-stay synaptic vesicle recycling", "positive regulation of kiss-and-stay synaptic vesicle recycling", "activation of kiss-and-run synaptic vesicle recycling", "up regulation of synaptic vesicle recycling", "positive regulation of kiss-and-run synaptic vesicle recycling", "upregulation of kiss-and-run synaptic vesicle recycling", "activation of synaptic vesicle recycling", "activation of kiss-and-stay synaptic vesicle recycling"], "types": ["T043"], "canonical_name": "positive regulation of synaptic vesicle recycling", "definition": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle recycling. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]"}
{"concept_id": "C3894459", "aliases": ["up-regulation of kiss-and-run synaptic vesicle recycling"], "types": ["T043"], "canonical_name": "up regulation of kiss-and-run synaptic vesicle recycling"}
{"concept_id": "C3894460", "aliases": ["up-regulation of kiss-and-stay synaptic vesicle recycling"], "types": ["T043"], "canonical_name": "up regulation of kiss-and-stay synaptic vesicle recycling"}
{"concept_id": "C3894461", "aliases": ["fluoride membrane transport", "transmembrane fluoride transport"], "types": ["T043"], "canonical_name": "fluoride transmembrane transport", "definition": "The process in which fluoride is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:24173035]"}
{"concept_id": "C3894462", "aliases": [], "types": ["T044"], "canonical_name": "fluoride transmembrane transporter activity", "definition": "Enables the transfer of fluoride from one side of a membrane to the other. [GO_REF:0000070, GOC:TermGenie, PMID:24173035]"}
{"concept_id": "C3894463", "aliases": ["regulation of reactive oxygen species anabolism", "regulation of reactive oxygen species formation", "regulation of reactive oxygen species biosynthesis", "regulation of reactive oxygen species synthesis"], "types": ["T044"], "canonical_name": "regulation of reactive oxygen species biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]"}
{"concept_id": "C3894464", "aliases": ["regulation of reactive oxygen species generation", "regulation of ROS generation"], "types": ["T044"], "canonical_name": "regulation of ROS formation"}
{"concept_id": "C3894465", "aliases": ["inhibition of reactive oxygen species biosynthetic process", "negative regulation of ROS generation", "negative regulation of reactive oxygen species biosynthesis", "down regulation of reactive oxygen species formation", "downregulation of ROS generation", "inhibition of ROS formation", "downregulation of reactive oxygen species generation", "down regulation of reactive oxygen species synthesis", "inhibition of reactive oxygen species generation", "down regulation of ROS generation", "downregulation of ROS formation", "down regulation of reactive oxygen species biosynthesis", "downregulation of reactive oxygen species synthesis", "prevention of ROS generation", "inhibition of reactive oxygen species anabolism", "down-regulation of reactive oxygen species anabolism", "down-regulation of reactive oxygen species synthesis", "down regulation of reactive oxygen species anabolism", "negative regulation of reactive oxygen species generation", "downregulation of reactive oxygen species formation", "down-regulation of ROS formation", "down-regulation of ROS generation", "down regulation of reactive oxygen species biosynthetic process", "inhibition of reactive oxygen species formation", "down-regulation of reactive oxygen species biosynthetic process", "down-regulation of reactive oxygen species generation", "inhibition of reactive oxygen species synthesis", "negative regulation of ROS formation", "down-regulation of reactive oxygen species formation", "down regulation of ROS formation", "down-regulation of reactive oxygen species biosynthesis", "downregulation of reactive oxygen species anabolism", "inhibition of reactive oxygen species biosynthesis", "down regulation of reactive oxygen species generation", "negative regulation of reactive oxygen species formation", "downregulation of reactive oxygen species biosynthesis", "downregulation of reactive oxygen species biosynthetic process", "inhibition of ROS generation", "negative regulation of reactive oxygen species anabolism", "negative regulation of reactive oxygen species synthesis"], "types": ["T044"], "canonical_name": "negative regulation of reactive oxygen species biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]"}
{"concept_id": "C3894466", "aliases": ["positive regulation of ROS generation", "up regulation of reactive oxygen species biosynthesis", "positive regulation of reactive oxygen species biosynthesis", "up-regulation of reactive oxygen species biosynthesis", "up-regulation of reactive oxygen species formation", "up-regulation of ROS formation", "activation of reactive oxygen species biosynthesis", "upregulation of reactive oxygen species biosynthetic process", "positive regulation of ROS formation", "upregulation of reactive oxygen species anabolism", "up regulation of reactive oxygen species generation", "up-regulation of reactive oxygen species anabolism", "up-regulation of ROS generation", "upregulation of reactive oxygen species generation", "up regulation of ROS generation", "positive regulation of reactive oxygen species anabolism", "positive regulation of reactive oxygen species generation", "upregulation of reactive oxygen species biosynthesis", "positive regulation of reactive oxygen species formation", "activation of reactive oxygen species biosynthetic process", "activation of reactive oxygen species synthesis", "upregulation of ROS generation", "up regulation of reactive oxygen species formation", "activation of reactive oxygen species generation", "activation of reactive oxygen species formation", "activation of ROS generation", "up-regulation of reactive oxygen species biosynthetic process", "up-regulation of reactive oxygen species generation", "up regulation of reactive oxygen species synthesis", "up regulation of reactive oxygen species anabolism", "up regulation of ROS formation", "upregulation of reactive oxygen species formation", "activation of reactive oxygen species anabolism", "upregulation of ROS formation", "upregulation of reactive oxygen species synthesis", "activation of ROS formation", "up-regulation of reactive oxygen species synthesis", "positive regulation of reactive oxygen species synthesis", "up regulation of reactive oxygen species biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of reactive oxygen species biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]"}
{"concept_id": "C3894467", "aliases": ["regulation of functional differentiation"], "types": ["T043"], "canonical_name": "regulation of cell maturation", "definition": "Any process that modulates the frequency, rate or extent of cell maturation. [GO_REF:0000058, GOC:TermGenie, PMID:17459944]"}
{"concept_id": "C3894468", "aliases": ["inhibition of functional differentiation", "down regulation of cell maturation", "negative regulation of functional differentiation", "down-regulation of cell maturation", "downregulation of cell maturation", "down-regulation of functional differentiation", "inhibition of cell maturation", "downregulation of functional differentiation", "down regulation of functional differentiation"], "types": ["T043"], "canonical_name": "negative regulation of cell maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. [GO_REF:0000058, GOC:TermGenie, PMID:17459944]"}
{"concept_id": "C3894469", "aliases": ["upregulation of functional differentiation", "positive regulation of functional differentiation", "upregulation of cell maturation", "up-regulation of functional differentiation", "up regulation of cell maturation", "up regulation of functional differentiation", "up-regulation of cell maturation", "activation of functional differentiation", "activation of cell maturation"], "types": ["T043"], "canonical_name": "positive regulation of cell maturation", "definition": "Any process that activates or increases the frequency, rate or extent of cell maturation. [GO_REF:0000058, GOC:TermGenie, PMID:17459944]"}
{"concept_id": "C3894470", "aliases": ["regulation of TORC1 signal transduction"], "types": ["T044"], "canonical_name": "regulation of TORC1 signaling", "definition": "Any process that modulates the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie]"}
{"concept_id": "C3894471", "aliases": [], "types": ["T043"], "canonical_name": "regulation of constitutive secretory pathway", "definition": "Any process that modulates the frequency, rate or extent of constitutive secretory pathway. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725]"}
{"concept_id": "C3894472", "aliases": ["downregulation of constitutive secretory pathway", "down-regulation of constitutive secretory pathway", "inhibition of constitutive secretory pathway", "down regulation of constitutive secretory pathway"], "types": ["T043"], "canonical_name": "negative regulation of constitutive secretory pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of constitutive secretory pathway. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725]"}
{"concept_id": "C3894473", "aliases": ["activation of constitutive secretory pathway", "upregulation of constitutive secretory pathway", "up regulation of constitutive secretory pathway", "up-regulation of constitutive secretory pathway"], "types": ["T043"], "canonical_name": "positive regulation of constitutive secretory pathway", "definition": "Any process that activates or increases the frequency, rate or extent of constitutive secretory pathway. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725]"}
{"concept_id": "C3894474", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic cytokinetic process", "definition": "Any process that modulates the frequency, rate or extent of mitotic cytokinetic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894475", "aliases": ["inhibition of mitotic cytokinetic process", "down-regulation of mitotic cytokinetic process", "downregulation of mitotic cytokinetic process", "down regulation of mitotic cytokinetic process"], "types": ["T043"], "canonical_name": "negative regulation of mitotic cytokinetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinetic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894476", "aliases": ["up regulation of mitotic cytokinetic process", "up-regulation of mitotic cytokinetic process", "activation of mitotic cytokinetic process", "upregulation of mitotic cytokinetic process"], "types": ["T043"], "canonical_name": "positive regulation of mitotic cytokinetic process", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic cytokinetic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894477", "aliases": ["calcitonin family receptor complex location"], "types": ["T026"], "canonical_name": "calcitonin family receptor complex", "definition": "A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416]"}
{"concept_id": "C3894478", "aliases": ["amylin receptor complex location"], "types": ["T026"], "canonical_name": "amylin receptor complex", "definition": "A protein complex which is capable of amylin receptor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416]"}
{"concept_id": "C3894479", "aliases": ["protein localisation in ciliary membrane", "protein localization in ciliary membrane", "protein localisation to ciliary membrane"], "types": ["T043"], "canonical_name": "protein localization to ciliary membrane", "definition": "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371]"}
{"concept_id": "C3894480", "aliases": [], "types": ["T043"], "canonical_name": "response to lipoic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus. [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760]"}
{"concept_id": "C3894481", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to lipoic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus. [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760]"}
{"concept_id": "C3894482", "aliases": ["down regulation of brown adipocyte cell differentiation", "down regulation of brown fat cell differentiation", "negative regulation of brown adipocyte cell differentiation", "down regulation of brown adipocyte differentiation", "downregulation of brown adipocyte differentiation", "inhibition of brown fat cell differentiation", "negative regulation of brown adipocyte differentiation", "inhibition of brown adipocyte differentiation", "down-regulation of brown adipocyte cell differentiation", "downregulation of brown fat cell differentiation", "down-regulation of brown fat cell differentiation", "downregulation of brown adipocyte cell differentiation", "down-regulation of brown adipocyte differentiation", "inhibition of brown adipocyte cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of brown fat cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of brown fat cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:23977283]"}
{"concept_id": "C3894483", "aliases": [], "types": ["T043"], "canonical_name": "protein transport from ciliary membrane to plasma membrane", "definition": "The directed movement of protein from ciliary membrane to plasma membrane. [GO_REF:0000078, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371]"}
{"concept_id": "C3894484", "aliases": ["geraniol metabolism"], "types": ["T044"], "canonical_name": "geraniol metabolic process", "definition": "The chemical reactions and pathways involving geraniol. [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656]"}
{"concept_id": "C3894485", "aliases": ["geraniol catabolism", "geraniol degradation", "geraniol breakdown"], "types": ["T044"], "canonical_name": "geraniol catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of geraniol. [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656]"}
{"concept_id": "C3894486", "aliases": ["geraniol synthesis", "geraniol formation", "geraniol anabolism", "geraniol biosynthesis"], "types": ["T044"], "canonical_name": "geraniol biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of geraniol. [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656]"}
{"concept_id": "C3894487", "aliases": ["regulation of stationary phase", "regulation of G1/G0 transition", "regulation of establishment of cell quiescence", "regulation of cell cycle quiescence"], "types": ["T043"], "canonical_name": "regulation of G1 to G0 transition", "definition": "Any process that modulates the frequency, rate or extent of G1 to G0 transition. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]"}
{"concept_id": "C3894488", "aliases": ["down regulation of G1/G0 transition", "downregulation of establishment of cell quiescence", "down-regulation of establishment of cell quiescence", "down regulation of G1 to G0 transition", "downregulation of G1/G0 transition", "negative regulation of G1/G0 transition", "negative regulation of establishment of cell quiescence", "down-regulation of G1 to G0 transition", "down-regulation of G1/G0 transition", "downregulation of G1 to G0 transition", "down regulation of establishment of cell quiescence"], "types": ["T043"], "canonical_name": "negative regulation of G1 to G0 transition", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of G1 to G0 transition. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]"}
{"concept_id": "C3894489", "aliases": ["downregulation of cell cycle quiescence", "negative regulation of cell cycle quiescence", "down-regulation of stationary phase", "down regulation of stationary phase", "negative regulation of stationary phase", "inhibition of establishment of cell quiescence", "down-regulation of cell cycle quiescence", "downregulation of stationary phase", "inhibition of cell cycle quiescence", "inhibition of stationary phase"], "types": ["T043"], "canonical_name": "down regulation of cell cycle quiescence"}
{"concept_id": "C3894490", "aliases": ["inhibition of G1/G0 transition"], "types": ["T043"], "canonical_name": "inhibition of G1 to G0 transition"}
{"concept_id": "C3894491", "aliases": ["up-regulation of G1 to G0 transition", "up regulation of G1/G0 transition", "positive regulation of G1/G0 transition", "up-regulation of G1/G0 transition", "upregulation of G1 to G0 transition", "up regulation of G1 to G0 transition", "up regulation of establishment of cell quiescence", "upregulation of establishment of cell quiescence", "upregulation of G1/G0 transition", "positive regulation of establishment of cell quiescence", "up-regulation of establishment of cell quiescence"], "types": ["T043"], "canonical_name": "positive regulation of G1 to G0 transition", "definition": "Any process that activates or increases the frequency, rate or extent of G1 to G0 transition. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]"}
{"concept_id": "C3894492", "aliases": ["activation of stationary phase", "up regulation of stationary phase", "up-regulation of cell cycle quiescence", "up regulation of cell cycle quiescence", "upregulation of cell cycle quiescence", "positive regulation of cell cycle quiescence", "positive regulation of stationary phase", "up-regulation of stationary phase", "upregulation of stationary phase", "activation of establishment of cell quiescence"], "types": ["T043"], "canonical_name": "activation of cell cycle quiescence"}
{"concept_id": "C3894493", "aliases": ["activation of G1/G0 transition"], "types": ["T043"], "canonical_name": "activation of G1 to G0 transition"}
{"concept_id": "C3894495", "aliases": ["regulation of androst-4-ene-3,17-dione formation", "regulation of androst-4-ene-3,17-dione synthesis", "regulation of androstenedione biosynthetic process", "regulation of androst-4-ene-3,17-dione anabolism", "regulation of androst-4-ene-3,17-dione biosynthesis"], "types": ["T040"], "canonical_name": "regulation of androst-4-ene-3,17-dione biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684]"}
{"concept_id": "C3894496", "aliases": ["down-regulation of androst-4-ene-3,17-dione synthesis", "down regulation of androst-4-ene-3,17-dione synthesis", "down-regulation of androst-4-ene-3,17-dione anabolism", "inhibition of androstenedione", "downregulation of androst-4-ene-3,17-dione anabolism", "negative regulation of androst-4-ene-3,17-dione formation", "downregulation of androst-4-ene-3,17-dione synthesis", "negative regulation of androst-4-ene-3,17-dione biosynthesis", "down regulation of androst-4-ene-3,17-dione anabolism", "downregulation of androst-4-ene-3,17-dione formation", "inhibition of androst-4-ene-3,17-dione biosynthetic process", "negative regulation of androst-4-ene-3,17-dione synthesis", "down regulation of androst-4-ene-3,17-dione biosynthetic process", "down regulation of androst-4-ene-3,17-dione biosynthesis", "down regulation of androstenedione biosynthetic process", "negative regulation of androst-4-ene-3,17-dione anabolism", "inhibition of androst-4-ene-3,17-dione formation", "down-regulation of androstenedione biosynthetic process", "negative regulation of androstenedione biosynthetic process", "downregulation of androst-4-ene-3,17-dione biosynthesis", "inhibition of androst-4-ene-3,17-dione synthesis", "downregulation of androstenedione biosynthetic process", "inhibition of androst-4-ene-3,17-dione biosynthesis", "down-regulation of androst-4-ene-3,17-dione biosynthesis", "down-regulation of androst-4-ene-3,17-dione formation", "downregulation of androst-4-ene-3,17-dione biosynthetic process", "inhibition of androst-4-ene-3,17-dione anabolism", "down regulation of androst-4-ene-3,17-dione formation", "down-regulation of androst-4-ene-3,17-dione biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of androst-4-ene-3,17-dione biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684]"}
{"concept_id": "C3894497", "aliases": ["upregulation of androst-4-ene-3,17-dione formation", "up-regulation of androst-4-ene-3,17-dione formation", "activation of androst-4-ene-3,17-dione biosynthetic process", "positive regulation of androst-4-ene-3,17-dione synthesis", "positive regulation of androstenedione biosynthetic process", "upregulation of androst-4-ene-3,17-dione anabolism", "activation of androst-4-ene-3,17-dione biosynthesis", "activation of androst-4-ene-3,17-dione synthesis", "up-regulation of androst-4-ene-3,17-dione anabolism", "up-regulation of androst-4-ene-3,17-dione biosynthesis", "positive regulation of androst-4-ene-3,17-dione formation", "activation of androst-4-ene-3,17-dione anabolism", "up regulation of androst-4-ene-3,17-dione anabolism", "up-regulation of androst-4-ene-3,17-dione synthesis", "upregulation of androst-4-ene-3,17-dione synthesis", "upregulation of androstenedione biosynthetic process", "up regulation of androst-4-ene-3,17-dione biosynthetic process", "up-regulation of androst-4-ene-3,17-dione biosynthetic process", "upregulation of androst-4-ene-3,17-dione biosynthesis", "up regulation of androstenedione biosynthetic process", "up regulation of androst-4-ene-3,17-dione formation", "upregulation of androst-4-ene-3,17-dione biosynthetic process", "activation of androst-4-ene-3,17-dione formation", "up-regulation of androstenedione biosynthetic process", "positive regulation of androst-4-ene-3,17-dione anabolism", "up regulation of androst-4-ene-3,17-dione synthesis", "up regulation of androst-4-ene-3,17-dione biosynthesis", "positive regulation of androst-4-ene-3,17-dione biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of androst-4-ene-3,17-dione biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684]"}
{"concept_id": "C3894498", "aliases": [], "types": ["T044"], "canonical_name": "activation of androstenedione"}
{"concept_id": "C3894499", "aliases": ["lactate breakdown", "lactate catabolism", "lactate degradation"], "types": ["T044"], "canonical_name": "lactate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lactate. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:8941775]"}
{"concept_id": "C3894500", "aliases": ["lagging strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle", "lagging strand elongation involved in mitotic DNA replication", "lagging strand elongation involved in mitotic nuclear cell cycle DNA replication", "lagging strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle", "lagging strand elongation involved in DNA replication during S phase involved in mitotic cell cycle", "lagging strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle"], "types": ["T045"], "canonical_name": "mitotic DNA replication lagging strand elongation", "definition": "Any lagging strand elongation that is involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894501", "aliases": ["leading strand elongation involved in DNA replication during S phase involved in mitotic cell cycle", "leading strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle", "leading strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle", "leading strand elongation involved in mitotic DNA replication", "leading strand elongation involved in mitotic nuclear cell cycle DNA replication", "leading strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle"], "types": ["T045"], "canonical_name": "mitotic DNA replication leading strand elongation", "definition": "Any leading strand elongation that is involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894502", "aliases": ["DNA replication, Okazaki fragment processing involved in DNA replication involved in S phase involved in mitotic cell cycle", "DNA replication, Okazaki fragment processing involved in DNA replication involved in S-phase involved in mitotic cell cycle", "DNA replication, Okazaki fragment processing involved in nuclear cell cycle DNA replication involved in mitotic cell cycle", "DNA replication, Okazaki fragment processing involved in DNA replication during S phase involved in mitotic cell cycle", "DNA replication, Okazaki fragment processing involved in mitotic nuclear cell cycle DNA replication"], "types": ["T045"], "canonical_name": "Okazaki fragment processing involved in mitotic DNA replication", "definition": "Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894503", "aliases": ["regulation of DNA replication involved in S-phase involved in mitotic cell cycle", "regulation of mitotic nuclear cell cycle DNA replication", "regulation of DNA replication during S phase involved in mitotic cell cycle", "regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle", "regulation of DNA replication involved in S phase involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "regulation of mitotic cell cycle DNA replication", "definition": "Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894504", "aliases": ["down-regulation of DNA replication involved in S phase involved in mitotic cell cycle", "downregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle", "down regulation of mitotic cell cycle DNA replication", "down-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle", "downregulation of DNA replication involved in S-phase involved in mitotic cell cycle", "negative regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle", "inhibition of DNA replication during S phase involved in mitotic cell cycle", "downregulation of mitotic nuclear cell cycle DNA replication", "negative regulation of DNA replication during S phase involved in mitotic cell cycle", "down-regulation of mitotic cell cycle DNA replication", "down regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle", "down-regulation of mitotic nuclear cell cycle DNA replication", "down-regulation of DNA replication during S phase involved in mitotic cell cycle", "inhibition of DNA replication involved in S phase involved in mitotic cell cycle", "downregulation of DNA replication involved in S phase involved in mitotic cell cycle", "downregulation of mitotic cell cycle DNA replication", "negative regulation of DNA replication involved in S-phase involved in mitotic cell cycle", "negative regulation of mitotic nuclear cell cycle DNA replication", "inhibition of mitotic cell cycle DNA replication", "downregulation of DNA replication during S phase involved in mitotic cell cycle", "down regulation of DNA replication involved in S phase involved in mitotic cell cycle", "down regulation of DNA replication involved in S-phase involved in mitotic cell cycle", "inhibition of mitotic nuclear cell cycle DNA replication", "down-regulation of DNA replication involved in S-phase involved in mitotic cell cycle", "negative regulation of DNA replication involved in S phase involved in mitotic cell cycle", "down regulation of mitotic nuclear cell cycle DNA replication", "down regulation of DNA replication during S phase involved in mitotic cell cycle", "inhibition of nuclear cell cycle DNA replication involved in mitotic cell cycle", "inhibition of DNA replication involved in S-phase involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "negative regulation of mitotic cell cycle DNA replication", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894505", "aliases": ["up regulation of DNA replication involved in S phase involved in mitotic cell cycle", "up regulation of mitotic cell cycle DNA replication", "positive regulation of DNA replication involved in S-phase involved in mitotic cell cycle", "upregulation of DNA replication involved in S-phase involved in mitotic cell cycle", "upregulation of mitotic nuclear cell cycle DNA replication", "up-regulation of DNA replication involved in S phase involved in mitotic cell cycle", "activation of mitotic cell cycle DNA replication", "up regulation of DNA replication involved in S-phase involved in mitotic cell cycle", "upregulation of DNA replication involved in S phase involved in mitotic cell cycle", "up-regulation of DNA replication involved in S-phase involved in mitotic cell cycle", "up-regulation of mitotic cell cycle DNA replication", "up regulation of mitotic nuclear cell cycle DNA replication", "activation of DNA replication involved in S phase involved in mitotic cell cycle", "up-regulation of mitotic nuclear cell cycle DNA replication", "positive regulation of mitotic nuclear cell cycle DNA replication", "activation of DNA replication during S phase involved in mitotic cell cycle", "upregulation of mitotic cell cycle DNA replication", "positive regulation of DNA replication involved in S phase involved in mitotic cell cycle", "activation of DNA replication involved in S-phase involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of mitotic cell cycle DNA replication", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894506", "aliases": ["activation of nuclear cell cycle DNA replication involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "activation of mitotic nuclear cell cycle DNA replication"}
{"concept_id": "C3894507", "aliases": ["up regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle", "positive regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle", "upregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle", "up-regulation of DNA replication during S phase involved in mitotic cell cycle", "upregulation of DNA replication during S phase involved in mitotic cell cycle", "up regulation of DNA replication during S phase involved in mitotic cell cycle", "up-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of DNA replication during S phase involved in mitotic cell cycle"}
{"concept_id": "C3894508", "aliases": ["regulation of DNA replication initiation involved in mitotic cell cycle DNA replication"], "types": ["T045"], "canonical_name": "regulation of mitotic DNA replication initiation", "definition": "Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894509", "aliases": ["negative regulation of DNA replication initiation involved in mitotic cell cycle DNA replication", "down regulation of DNA replication initiation involved in mitotic cell cycle DNA replication", "inhibition of DNA replication initiation involved in mitotic DNA replication", "downregulation of DNA replication initiation involved in mitotic DNA replication", "down regulation of DNA replication initiation involved in mitotic DNA replication", "down-regulation of DNA replication initiation involved in mitotic DNA replication", "down-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication", "downregulation of DNA replication initiation involved in mitotic cell cycle DNA replication", "inhibition of DNA replication initiation involved in mitotic cell cycle DNA replication"], "types": ["T045"], "canonical_name": "negative regulation of mitotic DNA replication initiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894510", "aliases": ["upregulation of DNA replication initiation involved in mitotic cell cycle DNA replication", "positive regulation of DNA replication initiation involved in mitotic cell cycle DNA replication", "up regulation of DNA replication initiation involved in mitotic DNA replication", "up-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication", "up-regulation of DNA replication initiation involved in mitotic DNA replication", "up regulation of DNA replication initiation involved in mitotic cell cycle DNA replication", "upregulation of DNA replication initiation involved in mitotic DNA replication"], "types": ["T045"], "canonical_name": "positive regulation of DNA replication initiation", "definition": "Any process that activates or increases the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894511", "aliases": ["activation of DNA replication initiation involved in mitotic cell cycle DNA replication"], "types": ["T045"], "canonical_name": "activation of DNA replication initiation involved in mitotic DNA replication"}
{"concept_id": "C3894512", "aliases": ["Okazaki initiator RNA removal involved in DNA replication involved in S phase involved in mitotic cell cycle", "DNA replication, removal of RNA primer involved in nuclear cell cycle DNA replication involved in mitotic cell cycle", "Okazaki initiator RNA removal involved in nuclear cell cycle DNA replication involved in mitotic cell cycle", "Okazaki initiator RNA removal involved in mitotic cell cycle DNA replication", "DNA replication, removal of RNA primer involved in DNA replication during S phase involved in mitotic cell cycle", "DNA replication, removal of RNA primer involved in mitotic nuclear cell cycle DNA replication", "DNA replication, removal of RNA primer involved in DNA replication involved in S phase involved in mitotic cell cycle", "DNA replication, removal of RNA primer involved in DNA replication involved in S-phase involved in mitotic cell cycle", "Okazaki initiator RNA removal involved in mitotic nuclear cell cycle DNA replication", "Okazaki initiator RNA removal involved in DNA replication involved in S-phase involved in mitotic cell cycle", "Okazaki initiator RNA removal involved in DNA replication during S phase involved in mitotic cell cycle"], "types": ["T045"], "canonical_name": "removal of RNA primer involved in mitotic DNA replication", "definition": "Any DNA replication, removal of RNA primer that is involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894514", "aliases": ["regulation of mitotic actomyosin contractile ring constriction", "regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle", "regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "regulation of mitotic actomyosin contractile ring contraction", "definition": "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring contraction. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894515", "aliases": ["down-regulation of mitotic actomyosin contractile ring contraction", "down-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "down regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "inhibition of mitotic actomyosin contractile ring contraction", "negative regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "negative regulation of mitotic actomyosin contractile ring constriction", "downregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle", "negative regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle", "down regulation of mitotic actomyosin contractile ring contraction", "inhibition of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle", "inhibition of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "down-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle", "downregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "downregulation of mitotic actomyosin contractile ring contraction", "down regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "negative regulation of mitotic actomyosin contractile ring contraction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring contraction. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894516", "aliases": ["positive regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle", "upregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "upregulation of mitotic actomyosin contractile ring contraction", "up regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle", "up-regulation of mitotic actomyosin contractile ring contraction", "up regulation of mitotic actomyosin contractile ring contraction", "up regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "positive regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "upregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle", "up-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle", "positive regulation of mitotic actomyosin contractile ring constriction", "up-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of mitotic actomyosin contractile ring contraction", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]"}
{"concept_id": "C3894517", "aliases": ["activation of mitotic actomyosin contractile ring contraction", "activation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "activation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle"}
{"concept_id": "C3894521", "aliases": ["cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "contractile ring assembly involved in mitotic cytokinesis", "actomyosin contractile ring assembly involved in cytokinesis after mitosis"], "types": ["T043"], "canonical_name": "mitotic actomyosin contractile ring assembly", "definition": "Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3894522", "aliases": ["protein localization to cell division site involved in contractile ring assembly involved in mitotic cytokinesis", "protein localisation to cell division site involved in mitotic actomyosin contractile ring assembly", "protein localization to cell division site involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis"], "types": ["T043"], "canonical_name": "protein localization to cell division site involved in mitotic actomyosin contractile ring assembly", "definition": "Any protein localization to cell division site that is involved in mitotic actomyosin contractile ring assembly. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3894523", "aliases": ["actin filament bundle assembly involved in mitotic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "mitotic contractile ring actin filament bundle assembly", "definition": "Any actin filament bundle assembly that is involved in mitotic actomyosin contractile ring assembly. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894524", "aliases": ["actin filament bundle convergence involved in contractile ring assembly involved in mitotic cytokinesis", "actin filament bundle convergence involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis", "actin filament bundle convergence involved in cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "actin filament bundle convergence involved in mitotic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "actin filament bundle convergence involved in mitotic contractile ring assembly", "definition": "Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3894525", "aliases": ["actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "actin filament organization involved in mitotic actomyosin contractile ring assembly", "actin filament organisation involved in mitotic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "mitotic actomyosin contractile ring assembly actin filament organization", "definition": "Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3894526", "aliases": ["regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly", "definition": "Any process that modulates the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3894527", "aliases": ["down-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "downregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "negative regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "down-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly", "negative regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly", "down-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly", "downregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly", "downregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly", "down regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly", "down regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "down regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "negative regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3894528", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis"}
{"concept_id": "C3894529", "aliases": ["inhibition of actin filament organization involved in mitotic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "inhibition of actin filament organisation involved in mitotic actomyosin contractile ring assembly"}
{"concept_id": "C3894530", "aliases": ["up-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly", "positive regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "up regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly", "up-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "positive regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly", "upregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "up regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis", "upregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly", "up-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly", "up regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly", "upregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "positive regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly", "definition": "Any process that activates or increases the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3894531", "aliases": [], "types": ["T043"], "canonical_name": "activation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis"}
{"concept_id": "C3894532", "aliases": ["activation of actin filament organization involved in mitotic actomyosin contractile ring assembly"], "types": ["T043"], "canonical_name": "activation of actin filament organisation involved in mitotic actomyosin contractile ring assembly"}
{"concept_id": "C3894545", "aliases": ["establishment of actomyosin contractile ring localization involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "establishment of mitotic actomyosin contractile ring localization", "definition": "Any establishment of actomyosin contractile ring localization that is involved in mitotic cell cycle. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3894546", "aliases": [], "types": ["T039"], "canonical_name": "regulation of lactation", "definition": "Any process that modulates the frequency, rate or extent of lactation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620]"}
{"concept_id": "C3894547", "aliases": ["downregulation of lactation", "down-regulation of lactation", "down regulation of lactation"], "types": ["T039"], "canonical_name": "negative regulation of lactation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lactation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620]"}
{"concept_id": "C3894548", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of lactation"}
{"concept_id": "C3894549", "aliases": ["up regulation of lactation", "upregulation of lactation", "up-regulation of lactation"], "types": ["T039"], "canonical_name": "positive regulation of lactation", "definition": "Any process that activates or increases the frequency, rate or extent of lactation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620]"}
{"concept_id": "C3894550", "aliases": [], "types": ["T039"], "canonical_name": "activation of lactation"}
{"concept_id": "C3894551", "aliases": ["up regulation of mitotic cytokinesis", "up-regulation of mitotic cytokinesis", "upregulation of mitotic cytokinesis", "positive regulation of cytokinesis after mitosis", "up regulation of cytokinesis after mitosis", "up-regulation of cytokinesis after mitosis", "upregulation of cytokinesis after mitosis"], "types": ["T043"], "canonical_name": "positive regulation of mitotic cytokinesis", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis. [GO_REF:0000058, GOC:TermGenie, PMID:24920823]"}
{"concept_id": "C3894552", "aliases": ["activation of mitotic cytokinesis"], "types": ["T043"], "canonical_name": "activation of cytokinesis after mitosis"}
{"concept_id": "C3894553", "aliases": [], "types": ["T043"], "canonical_name": "response to simvastatin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug. [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23100282]"}
{"concept_id": "C3894554", "aliases": [], "types": ["T043"], "canonical_name": "response to acetylsalicylate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aspirin (acetylsalicylate) stimulus. Aspirin is a non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity. [GO_REF:0000071, GOC:TermGenie, PMID:23392654]"}
{"concept_id": "C3894555", "aliases": [], "types": ["T043"], "canonical_name": "response to clopidogrel", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clopidogrel stimulus. Clopidogrel is a is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. [GO_REF:0000071, GOC:TermGenie, PMID:23392654]"}
{"concept_id": "C3894556", "aliases": [], "types": ["T043"], "canonical_name": "response to dehydroepiandrosterone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]"}
{"concept_id": "C3894557", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to dehydroepiandrosterone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]"}
{"concept_id": "C3894558", "aliases": [], "types": ["T043"], "canonical_name": "response to 11-deoxycorticosterone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]"}
{"concept_id": "C3894559", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to 11-deoxycorticosterone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]"}
{"concept_id": "C3894560", "aliases": [], "types": ["T043"], "canonical_name": "bundle sheath cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a bundle sheath cell. [GO_REF:0000086, GOC:tb, GOC:TermGenie, PMID:24517883]"}
{"concept_id": "C3894561", "aliases": ["regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "regulation of mitotic cytokinesis, actomyosin contractile ring assembly", "regulation of contractile ring assembly involved in mitotic cytokinesis", "regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis"], "types": ["T043"], "canonical_name": "regulation of mitotic actomyosin contractile ring assembly", "definition": "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring assembly. [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290]"}
{"concept_id": "C3894562", "aliases": ["down regulation of mitotic actomyosin contractile ring assembly", "down regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis", "downregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis", "down-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis", "negative regulation of contractile ring assembly involved in mitotic cytokinesis", "down regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "downregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "down-regulation of mitotic actomyosin contractile ring assembly", "down-regulation of contractile ring assembly involved in mitotic cytokinesis", "negative regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "downregulation of contractile ring assembly involved in mitotic cytokinesis", "down-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "negative regulation of mitotic cytokinesis, actomyosin contractile ring assembly", "downregulation of mitotic actomyosin contractile ring assembly", "negative regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis", "down regulation of contractile ring assembly involved in mitotic cytokinesis"], "types": ["T043"], "canonical_name": "negative regulation of mitotic actomyosin contractile ring assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring assembly. [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290]"}
{"concept_id": "C3894563", "aliases": ["inhibition of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "inhibition of mitotic actomyosin contractile ring assembly", "inhibition of contractile ring assembly involved in mitotic cytokinesis"], "types": ["T043"], "canonical_name": "inhibition of actomyosin contractile ring assembly involved in cytokinesis after mitosis"}
{"concept_id": "C3894564", "aliases": ["positive regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis", "up-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "up regulation of mitotic actomyosin contractile ring assembly", "up regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "positive regulation of contractile ring assembly involved in mitotic cytokinesis", "up regulation of contractile ring assembly involved in mitotic cytokinesis", "positive regulation of mitotic cytokinesis, actomyosin contractile ring assembly", "upregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "upregulation of mitotic actomyosin contractile ring assembly", "up-regulation of contractile ring assembly involved in mitotic cytokinesis", "upregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis", "positive regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis", "up-regulation of mitotic actomyosin contractile ring assembly", "up-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis", "up regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis", "upregulation of contractile ring assembly involved in mitotic cytokinesis"], "types": ["T043"], "canonical_name": "positive regulation of mitotic actomyosin contractile ring assembly", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring assembly. [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290]"}
{"concept_id": "C3894565", "aliases": ["activation of contractile ring assembly involved in mitotic cytokinesis", "activation of mitotic actomyosin contractile ring assembly", "activation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis"], "types": ["T043"], "canonical_name": "activation of actomyosin contractile ring assembly involved in cytokinesis after mitosis"}
{"concept_id": "C3894566", "aliases": ["translation repressor complex location"], "types": ["T026"], "canonical_name": "translation repressor complex", "definition": "A protein complex which is capable of translation repressor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:14723848]"}
{"concept_id": "C3894567", "aliases": ["ATPase inhibitor complex location"], "types": ["T026"], "canonical_name": "ATPase inhibitor complex", "definition": "A protein complex which is capable of ATPase inhibitor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16170325]"}
{"concept_id": "C3894568", "aliases": ["regulation of mitotic cell cycle spindle checkpoint"], "types": ["T043"], "canonical_name": "regulation of mitotic spindle checkpoint", "definition": "Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint. [GO_REF:0000058, GOC:TermGenie, PMID:23442800]"}
{"concept_id": "C3894569", "aliases": [], "types": ["T043"], "canonical_name": "regulation of establishment of actomyosin contractile ring localization involved in mitotic cell cycle", "definition": "Any process that modulates the frequency, rate or extent of establishment of actomyosin contractile ring localization involved in mitotic cell cycle. [GO_REF:0000058, GOC:TermGenie, PMID:24165938]"}
{"concept_id": "C3894570", "aliases": [], "types": ["T045"], "canonical_name": "regulation of nucleic acid-templated transcription", "definition": "Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription. [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw]"}
{"concept_id": "C3894571", "aliases": ["inhibition of nucleic acid-templated transcription", "downregulation of nucleic acid-templated transcription", "down-regulation of nucleic acid-templated transcription", "down regulation of nucleic acid-templated transcription"], "types": ["T045"], "canonical_name": "negative regulation of nucleic acid-templated transcription", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription. [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw]"}
{"concept_id": "C3894572", "aliases": ["up regulation of nucleic acid-templated transcription", "upregulation of nucleic acid-templated transcription", "up-regulation of nucleic acid-templated transcription"], "types": ["T045"], "canonical_name": "positive regulation of nucleic acid-templated transcription", "definition": "Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription. [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw]"}
{"concept_id": "C3894573", "aliases": [], "types": ["T045"], "canonical_name": "activation of nucleic acid-templated transcription"}
{"concept_id": "C3894574", "aliases": ["liposaccharide metabolism"], "types": ["T044"], "canonical_name": "liposaccharide metabolic process", "definition": "The chemical reactions and pathways involving liposaccharide. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:9452964]"}
{"concept_id": "C3894575", "aliases": ["mucopolysaccharide metabolism"], "types": ["T044"], "canonical_name": "mucopolysaccharide metabolic process", "definition": "The chemical reactions and pathways involving mucopolysaccharide. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:4236091]"}
{"concept_id": "C3894576", "aliases": ["orotic acid metabolism"], "types": ["T044"], "canonical_name": "orotic acid metabolic process", "definition": "The chemical reactions and pathways involving orotic acid. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:10727948]"}
{"concept_id": "C3894577", "aliases": ["phytanic acid metabolism"], "types": ["T044"], "canonical_name": "phytanic acid metabolic process", "definition": "The chemical reactions and pathways involving phytanic acid. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:16799769]"}
{"concept_id": "C3894578", "aliases": ["ER to cytosol transport"], "types": ["T043"], "canonical_name": "endoplasmic reticulum to cytosol transport", "definition": "The directed movement of substances from endoplasmic reticulum to cytosol. [GO_REF:0000076, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]"}
{"concept_id": "C3894579", "aliases": [], "types": ["T043"], "canonical_name": "calcium ion transport from endoplasmic reticulum to cytosol"}
{"concept_id": "C3894580", "aliases": [], "types": ["T043"], "canonical_name": "calcium ion transport from cytosol to endoplasmic reticulum", "definition": "The directed movement of calcium ion from cytosol to endoplasmic reticulum. [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]"}
{"concept_id": "C3894581", "aliases": [], "types": ["T045"], "canonical_name": "regulation of single strand break repair", "definition": "Any process that modulates the frequency, rate or extent of single strand break repair. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]"}
{"concept_id": "C3894582", "aliases": ["down-regulation of single strand break repair", "downregulation of single strand break repair", "down regulation of single strand break repair", "inhibition of single strand break repair"], "types": ["T045"], "canonical_name": "negative regulation of single strand break repair", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of single strand break repair. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]"}
{"concept_id": "C3894583", "aliases": ["upregulation of single strand break repair", "up regulation of single strand break repair", "up-regulation of single strand break repair"], "types": ["T045"], "canonical_name": "positive regulation of single strand break repair", "definition": "Any process that activates or increases the frequency, rate or extent of single strand break repair. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]"}
{"concept_id": "C3894584", "aliases": [], "types": ["T045"], "canonical_name": "activation of single strand break repair"}
{"concept_id": "C3894585", "aliases": [], "types": ["T039"], "canonical_name": "regulation of mammary gland involution", "definition": "Any process that modulates the frequency, rate or extent of mammary gland involution. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222]"}
{"concept_id": "C3894586", "aliases": ["down-regulation of mammary gland involution", "down regulation of mammary gland involution", "downregulation of mammary gland involution"], "types": ["T039"], "canonical_name": "negative regulation of mammary gland involution", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mammary gland involution. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222]"}
{"concept_id": "C3894587", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of mammary gland involution"}
{"concept_id": "C3894588", "aliases": ["up regulation of mammary gland involution", "upregulation of mammary gland involution", "up-regulation of mammary gland involution"], "types": ["T039"], "canonical_name": "positive regulation of mammary gland involution", "definition": "Any process that activates or increases the frequency, rate or extent of mammary gland involution. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222]"}
{"concept_id": "C3894589", "aliases": [], "types": ["T039"], "canonical_name": "activation of mammary gland involution"}
{"concept_id": "C3894590", "aliases": [], "types": ["T039"], "canonical_name": "regulation of blood circulation", "definition": "Any process that modulates the frequency, rate or extent of blood circulation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]"}
{"concept_id": "C3894591", "aliases": [], "types": ["T039"], "canonical_name": "regulation of hemolymph circulation"}
{"concept_id": "C3894592", "aliases": ["downregulation of blood circulation", "down regulation of blood circulation", "down-regulation of blood circulation"], "types": ["T039"], "canonical_name": "negative regulation of blood circulation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]"}
{"concept_id": "C3894593", "aliases": ["downregulation of hemolymph circulation", "down-regulation of hemolymph circulation", "negative regulation of hemolymph circulation"], "types": ["T039"], "canonical_name": "down regulation of hemolymph circulation"}
{"concept_id": "C3894594", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of blood circulation"}
{"concept_id": "C3894595", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of hemolymph circulation"}
{"concept_id": "C3894596", "aliases": ["upregulation of blood circulation", "up-regulation of blood circulation", "up regulation of blood circulation"], "types": ["T039"], "canonical_name": "positive regulation of blood circulation", "definition": "Any process that activates or increases the frequency, rate or extent of blood circulation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]"}
{"concept_id": "C3894597", "aliases": [], "types": ["T039"], "canonical_name": "activation of blood circulation"}
{"concept_id": "C3894598", "aliases": [], "types": ["T039"], "canonical_name": "activation of hemolymph circulation"}
{"concept_id": "C3894599", "aliases": ["up regulation of hemolymph circulation", "up-regulation of hemolymph circulation", "upregulation of hemolymph circulation"], "types": ["T039"], "canonical_name": "positive regulation of hemolymph circulation"}
{"concept_id": "C3894600", "aliases": ["regulation of plasma membrane tubulation"], "types": ["T043"], "canonical_name": "regulation of membrane tubulation", "definition": "Any process that modulates the frequency, rate or extent of membrane tubulation. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]"}
{"concept_id": "C3894601", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vesicle scission"}
{"concept_id": "C3894602", "aliases": ["downregulation of membrane tubulation", "down-regulation of plasma membrane tubulation", "downregulation of plasma membrane tubulation", "negative regulation of plasma membrane tubulation", "down-regulation of membrane tubulation", "down regulation of membrane tubulation", "down regulation of plasma membrane tubulation"], "types": ["T043"], "canonical_name": "negative regulation of membrane tubulation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane tubulation. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]"}
{"concept_id": "C3894603", "aliases": ["inhibition of plasma membrane tubulation"], "types": ["T043"], "canonical_name": "inhibition of membrane tubulation"}
{"concept_id": "C3894604", "aliases": ["up-regulation of membrane tubulation", "upregulation of membrane tubulation", "up regulation of plasma membrane tubulation", "up regulation of membrane tubulation", "up-regulation of plasma membrane tubulation", "positive regulation of plasma membrane tubulation", "upregulation of plasma membrane tubulation"], "types": ["T043"], "canonical_name": "positive regulation of membrane tubulation", "definition": "Any process that activates or increases the frequency, rate or extent of membrane tubulation. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]"}
{"concept_id": "C3894605", "aliases": ["activation of plasma membrane tubulation"], "types": ["T043"], "canonical_name": "activation of membrane tubulation"}
{"concept_id": "C3894606", "aliases": ["regulation of dCDP synthesis", "regulation of dCDP anabolism", "regulation of dCDP biosynthesis", "regulation of dCDP formation"], "types": ["T044"], "canonical_name": "regulation of dCDP biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of dCDP biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:16317005]"}
{"concept_id": "C3894607", "aliases": ["down-regulation of dCDP formation", "down-regulation of dCDP synthesis", "downregulation of dCDP synthesis", "downregulation of dCDP biosynthesis", "downregulation of dCDP anabolism", "negative regulation of dCDP biosynthesis", "down regulation of dCDP anabolism", "negative regulation of dCDP formation", "negative regulation of dCDP anabolism", "down-regulation of dCDP biosynthesis", "negative regulation of dCDP synthesis", "down regulation of dCDP synthesis", "down-regulation of dCDP biosynthetic process", "down regulation of dCDP biosynthesis", "down-regulation of dCDP anabolism", "downregulation of dCDP biosynthetic process", "down regulation of dCDP biosynthetic process", "downregulation of dCDP formation", "down regulation of dCDP formation"], "types": ["T044"], "canonical_name": "negative regulation of dCDP biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dCDP biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:16317005]"}
{"concept_id": "C3894608", "aliases": ["inhibition of dCDP biosynthesis", "inhibition of dCDP synthesis", "inhibition of dCDP formation", "inhibition of dCDP biosynthetic process"], "types": ["T044"], "canonical_name": "inhibition of dCDP anabolism"}
{"concept_id": "C3894609", "aliases": ["regulation of cellular secretion"], "types": ["T043"], "canonical_name": "regulation of secretion by cell", "definition": "Any process that modulates the frequency, rate or extent of secretion by cell. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]"}
{"concept_id": "C3894610", "aliases": ["downregulation of secretion by cell", "downregulation of cellular secretion", "down-regulation of cellular secretion", "down regulation of secretion by cell", "negative regulation of cellular secretion", "down regulation of cellular secretion", "down-regulation of secretion by cell"], "types": ["T043"], "canonical_name": "negative regulation of secretion by cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]"}
{"concept_id": "C3894611", "aliases": ["inhibition of secretion by cell"], "types": ["T043"], "canonical_name": "inhibition of cellular secretion"}
{"concept_id": "C3894612", "aliases": ["up regulation of cellular secretion", "up regulation of secretion by cell", "upregulation of cellular secretion", "positive regulation of cellular secretion", "up-regulation of secretion by cell", "upregulation of secretion by cell", "up-regulation of cellular secretion"], "types": ["T043"], "canonical_name": "positive regulation of secretion by cell", "definition": "Any process that activates or increases the frequency, rate or extent of secretion by cell. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]"}
{"concept_id": "C3894613", "aliases": ["activation of secretion by cell"], "types": ["T043"], "canonical_name": "activation of cellular secretion"}
{"concept_id": "C3894614", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein targeting", "definition": "Any process that modulates the frequency, rate or extent of protein targeting. [GO_REF:0000058, GOC:TermGenie]"}
{"concept_id": "C3894615", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nascent polypeptide association"}
{"concept_id": "C3894616", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein sorting along secretory pathway"}
{"concept_id": "C3894617", "aliases": ["regulation of lactose synthesis", "regulation of lactose anabolism", "regulation of lactose formation", "regulation of lactose biosynthesis"], "types": ["T044"], "canonical_name": "regulation of lactose biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of lactose biosynthetic process. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418]"}
{"concept_id": "C3894618", "aliases": ["negative regulation of lactose anabolism", "down regulation of lactose biosynthetic process", "down-regulation of lactose anabolism", "negative regulation of lactose formation", "down regulation of lactose biosynthesis", "down-regulation of lactose synthesis", "negative regulation of lactose biosynthesis", "negative regulation of lactose synthesis", "down-regulation of lactose biosynthesis", "downregulation of lactose anabolism", "downregulation of lactose biosynthetic process", "down-regulation of lactose formation", "downregulation of lactose synthesis", "down regulation of lactose formation", "down-regulation of lactose biosynthetic process", "down regulation of lactose anabolism", "downregulation of lactose biosynthesis", "downregulation of lactose formation", "down regulation of lactose synthesis"], "types": ["T044"], "canonical_name": "negative regulation of lactose biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lactose biosynthetic process. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418]"}
{"concept_id": "C3894619", "aliases": ["inhibition of lactose biosynthesis", "inhibition of lactose formation", "inhibition of lactose synthesis", "inhibition of lactose biosynthetic process"], "types": ["T044"], "canonical_name": "inhibition of lactose anabolism"}
{"concept_id": "C3894620", "aliases": ["upregulation of lactose biosynthesis", "upregulation of lactose anabolism", "up regulation of lactose anabolism", "up regulation of lactose formation", "up-regulation of lactose formation", "positive regulation of lactose biosynthesis", "up regulation of lactose biosynthesis", "up-regulation of lactose synthesis", "up regulation of lactose biosynthetic process", "up-regulation of lactose anabolism", "up-regulation of lactose biosynthetic process", "positive regulation of lactose anabolism", "upregulation of lactose formation", "positive regulation of lactose synthesis", "upregulation of lactose synthesis", "up-regulation of lactose biosynthesis", "up regulation of lactose synthesis", "upregulation of lactose biosynthetic process", "positive regulation of lactose formation"], "types": ["T044"], "canonical_name": "positive regulation of lactose biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of lactose biosynthetic process. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418]"}
{"concept_id": "C3894621", "aliases": ["activation of lactose synthesis", "activation of lactose formation", "activation of lactose biosynthesis", "activation of lactose biosynthetic process"], "types": ["T044"], "canonical_name": "activation of lactose anabolism"}
{"concept_id": "C3894622", "aliases": [], "types": ["T043"], "canonical_name": "meiotic cell cycle process involved in oocyte maturation", "definition": "Any meiotic cell cycle process that is involved in oocyte maturation. [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395]"}
{"concept_id": "C3894623", "aliases": [], "types": ["T043"], "canonical_name": "meiosis involved in oocyte maturation"}
{"concept_id": "C3894624", "aliases": [], "types": ["T043"], "canonical_name": "regulation of meiotic cell cycle process involved in oocyte maturation", "definition": "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395]"}
{"concept_id": "C3894625", "aliases": [], "types": ["T043"], "canonical_name": "regulation of meiosis involved in oocyte maturation"}
{"concept_id": "C3894626", "aliases": ["protein localisation to postsynaptic membrane", "protein localisation in postsynaptic membrane", "protein localization in postsynaptic membrane"], "types": ["T043"], "canonical_name": "protein localization to postsynaptic membrane", "definition": "A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:9753322]"}
{"concept_id": "C3894627", "aliases": ["establishment of protein localisation in postsynaptic membrane", "establishment of protein localisation to postsynaptic membrane", "establishment of protein localization in postsynaptic membrane"], "types": ["T043"], "canonical_name": "establishment of protein localization to postsynaptic membrane", "definition": "The directed movement of a protein to a specific location in a postsynaptic membrane. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:9753322]"}
{"concept_id": "C3894628", "aliases": ["regulation of exosomal secretory pathway", "regulation of extracellular vesicular exosome secretion", "regulation of secretion of exosome"], "types": ["T043"], "canonical_name": "regulation of exosomal secretion", "definition": "Any process that modulates the frequency, rate or extent of exosomal secretion. [GO_REF:0000058, GOC:TermGenie, PMID:24105262]"}
{"concept_id": "C3894629", "aliases": [], "types": ["T043"], "canonical_name": "regulation of exosomal protein secretion"}
{"concept_id": "C3894630", "aliases": ["down-regulation of extracellular vesicular exosome secretion", "negative regulation of extracellular vesicular exosome secretion", "down-regulation of exosomal secretion", "downregulation of exosomal secretion", "negative regulation of secretion of exosome", "down regulation of secretion of exosome", "downregulation of exosomal secretory pathway", "down regulation of exosomal secretory pathway", "downregulation of extracellular vesicular exosome secretion", "down regulation of exosomal secretion", "down-regulation of exosomal secretory pathway", "negative regulation of exosomal secretory pathway", "downregulation of secretion of exosome", "down regulation of extracellular vesicular exosome secretion", "down-regulation of secretion of exosome"], "types": ["T043"], "canonical_name": "negative regulation of exosomal secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion. [GO_REF:0000058, GOC:TermGenie, PMID:24105262]"}
{"concept_id": "C3894631", "aliases": ["downregulation of exosomal protein secretion", "negative regulation of exosomal protein secretion", "down-regulation of exosomal protein secretion"], "types": ["T043"], "canonical_name": "down regulation of exosomal protein secretion"}
{"concept_id": "C3894632", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of exosomal protein secretion"}
{"concept_id": "C3894633", "aliases": ["inhibition of secretion of exosome"], "types": ["T043"], "canonical_name": "inhibition of exosomal secretion"}
{"concept_id": "C3894634", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of exosomal secretory pathway"}
{"concept_id": "C3894635", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of extracellular vesicular exosome secretion"}
{"concept_id": "C3894636", "aliases": ["upregulation of exosomal secretory pathway", "upregulation of exosomal secretion", "up regulation of extracellular vesicular exosome secretion", "up-regulation of secretion of exosome", "up-regulation of exosomal secretion", "upregulation of extracellular vesicular exosome secretion", "positive regulation of extracellular vesicular exosome secretion", "upregulation of secretion of exosome", "up-regulation of exosomal secretory pathway", "up regulation of secretion of exosome", "up regulation of exosomal secretory pathway", "positive regulation of exosomal secretory pathway", "positive regulation of secretion of exosome", "up-regulation of extracellular vesicular exosome secretion", "up regulation of exosomal secretion"], "types": ["T043"], "canonical_name": "positive regulation of exosomal secretion", "definition": "Any process that activates or increases the frequency, rate or extent of exosomal secretion. [GO_REF:0000058, GOC:TermGenie, PMID:24105262]"}
{"concept_id": "C3894637", "aliases": [], "types": ["T043"], "canonical_name": "activation of exosomal protein secretion"}
{"concept_id": "C3894638", "aliases": ["activation of secretion of exosome"], "types": ["T043"], "canonical_name": "activation of exosomal secretion"}
{"concept_id": "C3894639", "aliases": [], "types": ["T043"], "canonical_name": "activation of exosomal secretory pathway"}
{"concept_id": "C3894640", "aliases": [], "types": ["T043"], "canonical_name": "activation of extracellular vesicular exosome secretion"}
{"concept_id": "C3894641", "aliases": ["up-regulation of exosomal protein secretion", "upregulation of exosomal protein secretion", "up regulation of exosomal protein secretion"], "types": ["T043"], "canonical_name": "positive regulation of exosomal protein secretion"}
{"concept_id": "C3894642", "aliases": [], "types": ["T043"], "canonical_name": "response to butyrate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870]"}
{"concept_id": "C3894643", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to butyrate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870]"}
{"concept_id": "C3894644", "aliases": ["protein localisation to photoreceptor outer segment", "protein localisation in photoreceptor outer segment", "protein localization in photoreceptor outer segment"], "types": ["T043"], "canonical_name": "protein localization to photoreceptor outer segment", "definition": "A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment. [GO_REF:0000087, GOC:TermGenie, PMID:11481257, PMID:21867699]"}
{"concept_id": "C3894645", "aliases": ["regulation of GH activity"], "types": ["T044"], "canonical_name": "regulation of growth hormone activity", "definition": "Any process that modulates the frequency, rate or extent of growth hormone activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266]"}
{"concept_id": "C3894646", "aliases": [], "types": ["T044"], "canonical_name": "regulation of pituitary growth hormone activity"}
{"concept_id": "C3894647", "aliases": [], "types": ["T044"], "canonical_name": "regulation of placental growth hormone activity"}
{"concept_id": "C3894648", "aliases": ["downregulation of growth hormone activity", "downregulation of GH activity", "down-regulation of growth hormone activity", "down regulation of growth hormone activity", "negative regulation of GH activity", "down regulation of GH activity", "down-regulation of GH activity"], "types": ["T044"], "canonical_name": "negative regulation of growth hormone activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of growth hormone activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266]"}
{"concept_id": "C3894649", "aliases": ["down-regulation of pituitary growth hormone activity", "downregulation of pituitary growth hormone activity", "negative regulation of pituitary growth hormone activity"], "types": ["T044"], "canonical_name": "down regulation of pituitary growth hormone activity"}
{"concept_id": "C3894650", "aliases": ["negative regulation of placental growth hormone activity", "downregulation of placental growth hormone activity", "down-regulation of placental growth hormone activity"], "types": ["T044"], "canonical_name": "down regulation of placental growth hormone activity"}
{"concept_id": "C3894651", "aliases": ["inhibition of growth hormone activity"], "types": ["T044"], "canonical_name": "inhibition of GH activity"}
{"concept_id": "C3894652", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pituitary growth hormone activity"}
{"concept_id": "C3894653", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of placental growth hormone activity"}
{"concept_id": "C3894654", "aliases": ["upregulation of GH activity", "up regulation of growth hormone activity", "positive regulation of GH activity", "up regulation of GH activity", "up-regulation of growth hormone activity", "up-regulation of GH activity", "upregulation of growth hormone activity"], "types": ["T044"], "canonical_name": "positive regulation of growth hormone activity", "definition": "Any process that activates or increases the frequency, rate or extent of growth hormone activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266]"}
{"concept_id": "C3894655", "aliases": ["activation of growth hormone activity"], "types": ["T044"], "canonical_name": "activation of GH activity"}
{"concept_id": "C3894656", "aliases": [], "types": ["T044"], "canonical_name": "activation of pituitary growth hormone activity"}
{"concept_id": "C3894657", "aliases": [], "types": ["T044"], "canonical_name": "activation of placental growth hormone activity"}
{"concept_id": "C3894658", "aliases": ["up-regulation of pituitary growth hormone activity", "up regulation of pituitary growth hormone activity", "upregulation of pituitary growth hormone activity"], "types": ["T044"], "canonical_name": "positive regulation of pituitary growth hormone activity"}
{"concept_id": "C3894659", "aliases": ["up regulation of placental growth hormone activity", "up-regulation of placental growth hormone activity", "upregulation of placental growth hormone activity"], "types": ["T044"], "canonical_name": "positive regulation of placental growth hormone activity"}
{"concept_id": "C3894660", "aliases": ["regulation of extracellular vesicular exosome assembly"], "types": ["T043"], "canonical_name": "regulation of extracellular exosome assembly", "definition": "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly. [GO_REF:0000058, GOC:TermGenie, PMID:24105262]"}
{"concept_id": "C3894661", "aliases": ["down regulation of extracellular vesicular exosome assembly", "negative regulation of extracellular vesicular exosome assembly", "downregulation of extracellular vesicular exosome assembly", "down-regulation of extracellular vesicular exosome assembly"], "types": ["T043"], "canonical_name": "negative regulation of extracellular exosome assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly. [GO_REF:0000058, GOC:TermGenie, PMID:24105262]"}
{"concept_id": "C3894662", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of extracellular vesicular exosome assembly"}
{"concept_id": "C3894663", "aliases": ["up-regulation of extracellular vesicular exosome assembly", "upregulation of extracellular vesicular exosome assembly", "up regulation of extracellular vesicular exosome assembly", "positive regulation of extracellular vesicular exosome assembly"], "types": ["T043"], "canonical_name": "positive regulation of extracellular exosome assembly", "definition": "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly. [GO_REF:0000058, GOC:TermGenie, PMID:24105262]"}
{"concept_id": "C3894664", "aliases": [], "types": ["T043"], "canonical_name": "activation of extracellular vesicular exosome assembly"}
{"concept_id": "C3894665", "aliases": ["G-protein coupled receptor signaling pathway involved in defense response to Gram-negative bacteria", "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria", "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacteria", "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacteria", "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium", "G-protein-coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium", "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium", "GPCR signalling pathway involved in defence response to Gram-negative bacteria", "GPCR signaling pathway involved in defence response to Gram-negative bacteria", "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium", "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium", "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria", "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacterium", "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacteria", "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium", "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria", "GPCR signaling pathway involved in defense response to Gram-negative bacterium", "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacterium", "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacteria", "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria", "GPCR signalling pathway involved in defense response to Gram-negative bacteria", "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium", "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacterium", "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacterium", "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacteria", "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria", "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria", "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria", "GPCR signaling pathway involved in defence response to Gram-negative bacterium", "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacterium", "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium", "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium", "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium", "GPCR signalling pathway involved in defence response to Gram-negative bacterium", "GPCR signaling pathway involved in defense response to Gram-negative bacteria", "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria", "GPCR signalling pathway involved in defense response to Gram-negative bacterium", "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria"], "types": ["T044"], "canonical_name": "G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium", "definition": "A G protein-coupled receptor signaling pathway that is involved in the defense response to Gram-negative bacterium. [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:25303524]"}
{"concept_id": "C3894666", "aliases": ["G-protein-coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity", "G protein coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity", "G-protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity", "G-protein-coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity"], "types": ["T044"], "canonical_name": "G protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3894667", "aliases": [], "types": ["T044"], "canonical_name": "G-protein coupled receptor protein signal transduction involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3894668", "aliases": ["G-protein coupled receptor signalling pathway involved in Gram-negative antibacterial peptide activity"], "types": ["T044"], "canonical_name": "G-protein coupled receptor signaling pathway involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3894669", "aliases": ["GPCR signalling pathway involved in Gram-negative antibacterial peptide activity"], "types": ["T044"], "canonical_name": "GPCR signaling pathway involved in Gram-negative antibacterial peptide activity"}
{"concept_id": "C3894670", "aliases": ["regulation of TNFSF cytokine production"], "types": ["T044"], "canonical_name": "regulation of tumor necrosis factor superfamily cytokine production", "definition": "Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C3894671", "aliases": [], "types": ["T044"], "canonical_name": "regulation of TNF superfamily production"}
{"concept_id": "C3894672", "aliases": ["downregulation of tumor necrosis factor superfamily cytokine production", "down-regulation of tumor necrosis factor superfamily cytokine production", "down regulation of TNFSF cytokine production", "negative regulation of TNFSF cytokine production", "down-regulation of TNFSF cytokine production", "downregulation of TNFSF cytokine production", "down regulation of tumor necrosis factor superfamily cytokine production"], "types": ["T044"], "canonical_name": "negative regulation of tumor necrosis factor superfamily cytokine production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C3894673", "aliases": ["downregulation of TNF superfamily production", "negative regulation of TNF superfamily production", "down-regulation of TNF superfamily production"], "types": ["T044"], "canonical_name": "down regulation of TNF superfamily production"}
{"concept_id": "C3894674", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of TNF superfamily production"}
{"concept_id": "C3894675", "aliases": ["inhibition of tumor necrosis factor superfamily cytokine production"], "types": ["T044"], "canonical_name": "inhibition of TNFSF cytokine production"}
{"concept_id": "C3894676", "aliases": ["up-regulation of TNFSF cytokine production", "upregulation of tumor necrosis factor superfamily cytokine production", "up regulation of tumor necrosis factor superfamily cytokine production", "up regulation of TNFSF cytokine production", "upregulation of TNFSF cytokine production", "positive regulation of TNFSF cytokine production", "up-regulation of tumor necrosis factor superfamily cytokine production"], "types": ["T044"], "canonical_name": "positive regulation of tumor necrosis factor superfamily cytokine production", "definition": "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C3894677", "aliases": [], "types": ["T044"], "canonical_name": "activation of TNF superfamily production"}
{"concept_id": "C3894678", "aliases": ["activation of tumor necrosis factor superfamily cytokine production"], "types": ["T044"], "canonical_name": "activation of TNFSF cytokine production"}
{"concept_id": "C3894679", "aliases": ["up regulation of TNF superfamily production", "up-regulation of TNF superfamily production", "upregulation of TNF superfamily production"], "types": ["T044"], "canonical_name": "positive regulation of TNF superfamily production"}
{"concept_id": "C3894680", "aliases": ["3-cyano-L-alanine metabolism"], "types": ["T044"], "canonical_name": "3-cyano-L-alanine metabolic process", "definition": "The chemical reactions and pathways involving 3-cyano-L-alanine. [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024]"}
{"concept_id": "C3894681", "aliases": ["3-cyano-L-alanine breakdown", "3-cyano-L-alanine catabolism", "3-cyano-L-alanine degradation"], "types": ["T044"], "canonical_name": "3-cyano-L-alanine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine. [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024]"}
{"concept_id": "C3894682", "aliases": ["3-cyano-L-alanine biosynthesis", "3-cyano-L-alanine formation", "3-cyano-L-alanine anabolism", "3-cyano-L-alanine synthesis"], "types": ["T044"], "canonical_name": "3-cyano-L-alanine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of 3-cyano-L-alanine. [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024]"}
{"concept_id": "C3894683", "aliases": [], "types": ["T026"], "definition": "Any vesicle that is part of the extracellular region. [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]", "canonical_name": "extracellular vesicle"}
{"concept_id": "C3894684", "aliases": ["microtubule bundle formation involved in mitotic spindle midzone formation", "microtubule bundle formation involved in spindle midzone assembly involved in mitosis", "microtubule bundling involved in spindle midzone formation involved in mitosis", "microtubule bundling involved in spindle midzone assembly involved in mitosis", "microtubule bundling involved in spindle midzone biogenesis involved in mitosis", "microtubule bundling involved in mitotic spindle midzone formation"], "types": ["T043"], "canonical_name": "microtubule bundle formation involved in mitotic spindle midzone assembly", "definition": "Any microtubule bundle formation that is involved in spindle midzone assembly involved in mitosis. [GO_REF:0000060, GOC:TermGenie, PMID:15647375]"}
{"concept_id": "C3894685", "aliases": [], "types": ["T043"], "canonical_name": "microtubule bundling involved in mitotic spindle midzone assembly"}
{"concept_id": "C3894686", "aliases": ["microtubule bundling involved in horsetail-astral microtubule organisation", "microtubule bundling involved in horsetail-astral microtubule array organization", "microtubule bundle formation involved in horsetail-astral microtubule array organization", "microtubule bundling involved in horsetail-astral microtubule organization", "microtubule bundle formation involved in horsetail-astral microtubule organisation"], "types": ["T043"], "canonical_name": "microtubule bundle formation involved in horsetail-astral microtubule organization", "definition": "Any microtubule bundle formation that is involved in horsetail-astral microtubule organization. [GO_REF:0000060, GOC:TermGenie, PMID:15647375]"}
{"concept_id": "C3894687", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein localization to cilium", "definition": "Any process that modulates the frequency, rate or extent of protein localization to cilium. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]"}
{"concept_id": "C3894688", "aliases": ["downregulation of protein localization to cilium", "down regulation of protein localization to cilium", "down-regulation of protein localization to cilium"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to cilium", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]"}
{"concept_id": "C3894689", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein localization to cilium"}
{"concept_id": "C3894690", "aliases": ["up-regulation of protein localization to cilium", "up regulation of protein localization to cilium", "upregulation of protein localization to cilium"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to cilium", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to cilium. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]"}
{"concept_id": "C3894691", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein localization to cilium"}
{"concept_id": "C3894692", "aliases": ["regulation of protein localisation in ciliary membrane", "regulation of protein localisation to ciliary membrane", "regulation of protein localization in ciliary membrane"], "types": ["T043"], "canonical_name": "regulation of protein localization to ciliary membrane", "definition": "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]"}
{"concept_id": "C3894693", "aliases": ["down regulation of protein localisation to ciliary membrane", "down regulation of protein localization in ciliary membrane", "down-regulation of protein localisation in ciliary membrane", "down regulation of protein localization to ciliary membrane", "downregulation of protein localization in ciliary membrane", "down regulation of protein localisation in ciliary membrane", "down-regulation of protein localization to ciliary membrane", "down-regulation of protein localization in ciliary membrane", "downregulation of protein localization to ciliary membrane", "downregulation of protein localisation to ciliary membrane", "down-regulation of protein localisation to ciliary membrane", "downregulation of protein localisation in ciliary membrane", "negative regulation of protein localisation to ciliary membrane", "negative regulation of protein localization in ciliary membrane", "negative regulation of protein localisation in ciliary membrane"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to ciliary membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]"}
{"concept_id": "C3894694", "aliases": ["inhibition of protein localisation to ciliary membrane", "inhibition of protein localization to ciliary membrane", "inhibition of protein localization in ciliary membrane"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in ciliary membrane"}
{"concept_id": "C3894695", "aliases": ["upregulation of protein localisation to ciliary membrane", "up regulation of protein localization in ciliary membrane", "up regulation of protein localisation to ciliary membrane", "up-regulation of protein localization to ciliary membrane", "up regulation of protein localisation in ciliary membrane", "up-regulation of protein localisation in ciliary membrane", "positive regulation of protein localization in ciliary membrane", "up-regulation of protein localization in ciliary membrane", "up-regulation of protein localisation to ciliary membrane", "positive regulation of protein localisation to ciliary membrane", "positive regulation of protein localisation in ciliary membrane", "upregulation of protein localization in ciliary membrane", "up regulation of protein localization to ciliary membrane", "upregulation of protein localization to ciliary membrane", "upregulation of protein localisation in ciliary membrane"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to ciliary membrane", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]"}
{"concept_id": "C3894696", "aliases": ["activation of protein localization in ciliary membrane", "activation of protein localisation to ciliary membrane", "activation of protein localization to ciliary membrane"], "types": ["T043"], "canonical_name": "activation of protein localisation in ciliary membrane"}
{"concept_id": "C3894697", "aliases": ["regulation of PKD signal transduction", "regulation of protein kinase D signal transduction"], "types": ["T044"], "canonical_name": "regulation of protein kinase D signaling", "definition": "Any process that modulates the frequency, rate or extent of protein kinase D signaling. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]"}
{"concept_id": "C3894698", "aliases": [], "types": ["T044"], "canonical_name": "regulation of PKD signaling cascade"}
{"concept_id": "C3894699", "aliases": ["regulation of protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "regulation of protein kinase D signaling cascade"}
{"concept_id": "C3894700", "aliases": ["downregulation of PKD signal transduction", "down-regulation of protein kinase D signaling", "down regulation of protein kinase D signaling", "down-regulation of protein kinase D signal transduction", "down-regulation of PKD signal transduction", "downregulation of protein kinase D signaling", "down regulation of PKD signal transduction", "negative regulation of PKD signal transduction", "downregulation of protein kinase D signal transduction", "down regulation of protein kinase D signal transduction", "negative regulation of protein kinase D signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of protein kinase D signaling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase D signaling. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]"}
{"concept_id": "C3894701", "aliases": ["downregulation of PKD signaling cascade", "negative regulation of PKD signaling cascade", "down-regulation of PKD signaling cascade"], "types": ["T044"], "canonical_name": "down regulation of PKD signaling cascade"}
{"concept_id": "C3894702", "aliases": ["down-regulation of protein kinase D signalling cascade", "down-regulation of protein kinase D signaling cascade", "down regulation of protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "down regulation of protein kinase D signaling cascade"}
{"concept_id": "C3894703", "aliases": ["downregulation of protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "downregulation of protein kinase D signaling cascade"}
{"concept_id": "C3894704", "aliases": ["inhibition of protein kinase D signal transduction", "inhibition of protein kinase D signaling"], "types": ["T044"], "canonical_name": "inhibition of PKD signal transduction"}
{"concept_id": "C3894705", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of PKD signaling cascade"}
{"concept_id": "C3894706", "aliases": ["inhibition of protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "inhibition of protein kinase D signaling cascade"}
{"concept_id": "C3894707", "aliases": ["negative regulation of protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "negative regulation of protein kinase D signaling cascade"}
{"concept_id": "C3894708", "aliases": ["up regulation of PKD signal transduction", "up regulation of protein kinase D signaling", "up-regulation of PKD signal transduction", "up regulation of protein kinase D signal transduction", "upregulation of PKD signal transduction", "up-regulation of protein kinase D signaling", "upregulation of protein kinase D signal transduction", "upregulation of protein kinase D signaling", "positive regulation of protein kinase D signal transduction", "positive regulation of PKD signal transduction", "up-regulation of protein kinase D signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of protein kinase D signaling", "definition": "Any process that activates or increases the frequency, rate or extent of protein kinase D signaling. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]"}
{"concept_id": "C3894709", "aliases": ["activation of protein kinase D signal transduction"], "types": ["T044"], "canonical_name": "activation of PKD signal transduction"}
{"concept_id": "C3894710", "aliases": [], "types": ["T044"], "canonical_name": "activation of PKD signaling cascade"}
{"concept_id": "C3894711", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein kinase D signaling"}
{"concept_id": "C3894712", "aliases": ["activation of protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "activation of protein kinase D signaling cascade"}
{"concept_id": "C3894713", "aliases": ["up-regulation of PKD signaling cascade", "up regulation of PKD signaling cascade", "upregulation of PKD signaling cascade"], "types": ["T044"], "canonical_name": "positive regulation of PKD signaling cascade"}
{"concept_id": "C3894714", "aliases": ["positive regulation of protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "positive regulation of protein kinase D signaling cascade"}
{"concept_id": "C3894715", "aliases": ["up-regulation of protein kinase D signaling cascade", "up-regulation of protein kinase D signalling cascade", "up regulation of protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "up regulation of protein kinase D signaling cascade"}
{"concept_id": "C3894716", "aliases": ["upregulation of protein kinase D signalling cascade"], "types": ["T044"], "canonical_name": "upregulation of protein kinase D signaling cascade"}
{"concept_id": "C3894717", "aliases": ["downregulation of ER stress response", "downregulation of response to endoplasmic reticulum stress", "negative regulation of response to ER stress", "down regulation of ER stress response", "down-regulation of ER stress response", "down regulation of response to ER stress", "down-regulation of response to ER stress", "negative regulation of cellular response to endoplasmic reticulum stress", "downregulation of cellular response to endoplasmic reticulum stress", "down-regulation of response to endoplasmic reticulum stress", "downregulation of response to ER stress", "down regulation of cellular response to endoplasmic reticulum stress", "down-regulation of cellular response to endoplasmic reticulum stress", "down regulation of response to endoplasmic reticulum stress", "negative regulation of ER stress response"], "types": ["T043"], "canonical_name": "negative regulation of response to endoplasmic reticulum stress", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]"}
{"concept_id": "C3894718", "aliases": ["inhibition of response to endoplasmic reticulum stress"], "types": ["T043"], "canonical_name": "inhibition of cellular response to endoplasmic reticulum stress"}
{"concept_id": "C3894719", "aliases": ["inhibition of response to ER stress"], "types": ["T043"], "canonical_name": "inhibition of ER stress response"}
{"concept_id": "C3894720", "aliases": ["downregulation of cellular response to amino acid starvation", "down regulation of cellular response to amino acid starvation", "down-regulation of cellular response to amino acid starvation"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to amino acid starvation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to amino acid starvation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]"}
{"concept_id": "C3894721", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to amino acid starvation"}
{"concept_id": "C3894722", "aliases": ["cornified envelope formation"], "types": ["T043"], "canonical_name": "cornified envelope assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a cornified envelope. [GO_REF:0000079, GOC:pm, GOC:TermGenie, PMID:22226963, PMID:24794495]"}
{"concept_id": "C3894723", "aliases": [], "types": ["T040"], "canonical_name": "response to L-arginine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628]"}
{"concept_id": "C3894724", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to L-arginine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628]"}
{"concept_id": "C3894725", "aliases": ["regulation of ATP metabolism"], "types": ["T044"], "canonical_name": "regulation of ATP metabolic process", "definition": "Any process that modulates the frequency, rate or extent of ATP metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:20695849]"}
{"concept_id": "C3894726", "aliases": ["down-regulation of ATP metabolism", "negative regulation of ATP metabolism", "down-regulation of ATP metabolic process", "downregulation of ATP metabolic process", "down regulation of ATP metabolic process", "downregulation of ATP metabolism", "down regulation of ATP metabolism"], "types": ["T044"], "canonical_name": "negative regulation of ATP metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:20695849]"}
{"concept_id": "C3894727", "aliases": ["inhibition of ATP metabolism"], "types": ["T044"], "canonical_name": "inhibition of ATP metabolic process"}
{"concept_id": "C3894728", "aliases": ["positive regulation of ATP metabolism", "up regulation of ATP metabolic process", "upregulation of ATP metabolism", "up-regulation of ATP metabolic process", "up-regulation of ATP metabolism", "upregulation of ATP metabolic process", "up regulation of ATP metabolism"], "types": ["T044"], "canonical_name": "positive regulation of ATP metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of ATP metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:20695849]"}
{"concept_id": "C3894729", "aliases": ["activation of ATP metabolism"], "types": ["T044"], "canonical_name": "activation of ATP metabolic process"}
{"concept_id": "C3894730", "aliases": [], "types": ["T043"], "canonical_name": "regulation of basophil degranulation", "definition": "Any process that modulates the frequency, rate or extent of basophil degranulation. [GO_REF:0000058, GOC:TermGenie, PMID:10880837]"}
{"concept_id": "C3894731", "aliases": ["down-regulation of basophil degranulation", "down regulation of basophil degranulation", "downregulation of basophil degranulation"], "types": ["T043"], "canonical_name": "negative regulation of basophil degranulation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of basophil degranulation. [GO_REF:0000058, GOC:TermGenie, PMID:10880837]"}
{"concept_id": "C3894732", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of basophil degranulation"}
{"concept_id": "C3894733", "aliases": ["up regulation of basophil degranulation", "upregulation of basophil degranulation", "up-regulation of basophil degranulation"], "types": ["T043"], "canonical_name": "positive regulation of basophil degranulation", "definition": "Any process that activates or increases the frequency, rate or extent of basophil degranulation. [GO_REF:0000058, GOC:TermGenie, PMID:10880837]"}
{"concept_id": "C3894734", "aliases": [], "types": ["T043"], "canonical_name": "activation of basophil degranulation"}
{"concept_id": "C3894735", "aliases": ["regulation of histone deubiquitylation", "regulation of histone deubiquitinylation"], "types": ["T044"], "canonical_name": "regulation of histone deubiquitination", "definition": "Any process that modulates the frequency, rate or extent of histone deubiquitination. [GO_REF:0000058, GOC:TermGenie, PMID:24526689]"}
{"concept_id": "C3894736", "aliases": ["down-regulation of histone deubiquitinylation", "negative regulation of histone deubiquitylation", "down-regulation of histone deubiquitination", "downregulation of histone deubiquitylation", "down regulation of histone deubiquitylation", "down-regulation of histone deubiquitylation", "negative regulation of histone deubiquitinylation", "downregulation of histone deubiquitination", "down regulation of histone deubiquitinylation", "down regulation of histone deubiquitination", "downregulation of histone deubiquitinylation"], "types": ["T044"], "canonical_name": "negative regulation of histone deubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone deubiquitination. [GO_REF:0000058, GOC:TermGenie, PMID:24526689]"}
{"concept_id": "C3894737", "aliases": ["inhibition of histone deubiquitylation", "inhibition of histone deubiquitinylation"], "types": ["T044"], "canonical_name": "inhibition of histone deubiquitination"}
{"concept_id": "C3894738", "aliases": ["up-regulation of histone deubiquitylation", "up regulation of histone deubiquitylation", "positive regulation of histone deubiquitylation", "upregulation of histone deubiquitinylation", "up-regulation of histone deubiquitination", "upregulation of histone deubiquitination", "up-regulation of histone deubiquitinylation", "positive regulation of histone deubiquitinylation", "up regulation of histone deubiquitination", "up regulation of histone deubiquitinylation", "upregulation of histone deubiquitylation"], "types": ["T044"], "canonical_name": "positive regulation of histone deubiquitination", "definition": "Any process that activates or increases the frequency, rate or extent of histone deubiquitination. [GO_REF:0000058, GOC:TermGenie, PMID:24526689]"}
{"concept_id": "C3894739", "aliases": ["activation of histone deubiquitylation", "activation of histone deubiquitinylation"], "types": ["T044"], "canonical_name": "activation of histone deubiquitination"}
{"concept_id": "C3894740", "aliases": ["regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis"], "types": ["T043"], "canonical_name": "regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "definition": "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:23388056]"}
{"concept_id": "C3894741", "aliases": ["down regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "down regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis", "downregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "down-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis", "downregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis", "down-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"], "types": ["T043"], "canonical_name": "negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:23388056]"}
{"concept_id": "C3894742", "aliases": ["inhibition of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"], "types": ["T043"], "canonical_name": "inhibition of blood vessel endothelial cell proliferation during sprouting angiogenesis"}
{"concept_id": "C3894743", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis"}
{"concept_id": "C3894744", "aliases": ["upregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis", "positive regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis", "up-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "upregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "up-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis", "up regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "up regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis"], "types": ["T043"], "canonical_name": "positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:23388056]"}
{"concept_id": "C3894745", "aliases": ["activation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"], "types": ["T043"], "canonical_name": "activation of blood vessel endothelial cell proliferation during sprouting angiogenesis"}
{"concept_id": "C3894746", "aliases": ["regulation of mucopeptide glucohydrolase activity", "regulation of 1,4-N-acetylmuramidase activity", "regulation of peptidoglycan N-acetylmuramoylhydrolase activity", "regulation of N,O-diacetylmuramidase activity", "regulation of mucopeptide N-acetylmuramoylhydrolase activity", "regulation of muramidase activity"], "types": ["T044"], "canonical_name": "regulation of lysozyme activity", "definition": "Any process that modulates the frequency, rate or extent of lysozyme activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697]"}
{"concept_id": "C3894747", "aliases": [], "types": ["T044"], "canonical_name": "regulation of globulin G"}
{"concept_id": "C3894748", "aliases": [], "types": ["T044"], "canonical_name": "regulation of globulin G1"}
{"concept_id": "C3894749", "aliases": [], "types": ["T044"], "canonical_name": "regulation of L-7001"}
{"concept_id": "C3894750", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lysozyme g"}
{"concept_id": "C3894751", "aliases": [], "types": ["T044"], "canonical_name": "regulation of PR1-lysozyme"}
{"concept_id": "C3894752", "aliases": ["down-regulation of peptidoglycan N-acetylmuramoylhydrolase activity", "down regulation of lysozyme activity", "down regulation of N,O-diacetylmuramidase activity", "downregulation of peptidoglycan N-acetylmuramoylhydrolase activity", "downregulation of N,O-diacetylmuramidase activity", "downregulation of muramidase activity", "down-regulation of mucopeptide glucohydrolase activity", "down regulation of mucopeptide N-acetylmuramoylhydrolase activity", "negative regulation of 1,4-N-acetylmuramidase activity", "down-regulation of lysozyme activity", "downregulation of mucopeptide glucohydrolase activity", "down-regulation of mucopeptide N-acetylmuramoylhydrolase activity", "negative regulation of mucopeptide N-acetylmuramoylhydrolase activity", "downregulation of mucopeptide N-acetylmuramoylhydrolase activity", "negative regulation of muramidase activity", "down-regulation of N,O-diacetylmuramidase activity", "downregulation of lysozyme activity", "down regulation of 1,4-N-acetylmuramidase activity", "downregulation of 1,4-N-acetylmuramidase activity", "down-regulation of muramidase activity", "down regulation of mucopeptide glucohydrolase activity", "down regulation of muramidase activity", "negative regulation of N,O-diacetylmuramidase activity", "down regulation of peptidoglycan N-acetylmuramoylhydrolase activity", "negative regulation of peptidoglycan N-acetylmuramoylhydrolase activity", "down-regulation of 1,4-N-acetylmuramidase activity", "negative regulation of mucopeptide glucohydrolase activity"], "types": ["T044"], "canonical_name": "negative regulation of lysozyme activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lysozyme activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697]"}
{"concept_id": "C3894753", "aliases": ["down-regulation of globulin G", "downregulation of globulin G", "negative regulation of globulin G"], "types": ["T044"], "canonical_name": "down regulation of globulin G"}
{"concept_id": "C3894754", "aliases": ["down-regulation of globulin G1", "downregulation of globulin G1", "negative regulation of globulin G1"], "types": ["T044"], "canonical_name": "down regulation of globulin G1"}
{"concept_id": "C3894755", "aliases": ["down-regulation of L-7001"], "types": ["T044"], "canonical_name": "down regulation of L-7001"}
{"concept_id": "C3894756", "aliases": ["negative regulation of lysozyme g", "down-regulation of lysozyme g"], "types": ["T044"], "canonical_name": "down regulation of lysozyme g"}
{"concept_id": "C3894757", "aliases": ["down-regulation of PR1-lysozyme"], "types": ["T044"], "canonical_name": "down regulation of PR1-lysozyme"}
{"concept_id": "C3894758", "aliases": ["negative regulation of L-7001"], "types": ["T044"], "canonical_name": "downregulation of L-7001"}
{"concept_id": "C3894759", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of lysozyme g"}
{"concept_id": "C3894760", "aliases": ["negative regulation of PR1-lysozyme"], "types": ["T044"], "canonical_name": "downregulation of PR1-lysozyme"}
{"concept_id": "C3894761", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1,4-N-acetylmuramidase activity"}
{"concept_id": "C3894762", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of globulin G"}
{"concept_id": "C3894763", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of globulin G1"}
{"concept_id": "C3894764", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-7001"}
{"concept_id": "C3894765", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysozyme activity"}
{"concept_id": "C3894766", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysozyme g"}
{"concept_id": "C3894767", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mucopeptide glucohydrolase activity"}
{"concept_id": "C3894768", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mucopeptide N-acetylmuramoylhydrolase activity"}
{"concept_id": "C3894769", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of muramidase activity"}
{"concept_id": "C3894770", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of N,O-diacetylmuramidase activity"}
{"concept_id": "C3894771", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of peptidoglycan N-acetylmuramoylhydrolase activity"}
{"concept_id": "C3894772", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of PR1-lysozyme"}
{"concept_id": "C3894773", "aliases": ["upregulation of 1,4-N-acetylmuramidase activity", "positive regulation of peptidoglycan N-acetylmuramoylhydrolase activity", "up-regulation of mucopeptide glucohydrolase activity", "up-regulation of N,O-diacetylmuramidase activity", "positive regulation of mucopeptide N-acetylmuramoylhydrolase activity", "upregulation of mucopeptide N-acetylmuramoylhydrolase activity", "up-regulation of muramidase activity", "upregulation of lysozyme activity", "up-regulation of mucopeptide N-acetylmuramoylhydrolase activity", "positive regulation of N,O-diacetylmuramidase activity", "upregulation of mucopeptide glucohydrolase activity", "up-regulation of 1,4-N-acetylmuramidase activity", "positive regulation of muramidase activity", "up regulation of peptidoglycan N-acetylmuramoylhydrolase activity", "up-regulation of peptidoglycan N-acetylmuramoylhydrolase activity", "up regulation of N,O-diacetylmuramidase activity", "positive regulation of mucopeptide glucohydrolase activity", "up-regulation of lysozyme activity", "up regulation of 1,4-N-acetylmuramidase activity", "up regulation of mucopeptide N-acetylmuramoylhydrolase activity", "up regulation of mucopeptide glucohydrolase activity", "upregulation of muramidase activity", "upregulation of peptidoglycan N-acetylmuramoylhydrolase activity", "upregulation of N,O-diacetylmuramidase activity", "up regulation of muramidase activity", "up regulation of lysozyme activity", "positive regulation of 1,4-N-acetylmuramidase activity"], "types": ["T044"], "canonical_name": "positive regulation of lysozyme activity", "definition": "Any process that activates or increases the frequency, rate or extent of lysozyme activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697]"}
{"concept_id": "C3894774", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1,4-N-acetylmuramidase activity"}
{"concept_id": "C3894775", "aliases": [], "types": ["T044"], "canonical_name": "activation of globulin G"}
{"concept_id": "C3894776", "aliases": [], "types": ["T044"], "canonical_name": "activation of globulin G1"}
{"concept_id": "C3894777", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-7001"}
{"concept_id": "C3894778", "aliases": [], "types": ["T044"], "canonical_name": "activation of lysozyme activity"}
{"concept_id": "C3894779", "aliases": [], "types": ["T044"], "canonical_name": "activation of lysozyme g"}
{"concept_id": "C3894780", "aliases": [], "types": ["T044"], "canonical_name": "activation of mucopeptide glucohydrolase activity"}
{"concept_id": "C3894781", "aliases": [], "types": ["T044"], "canonical_name": "activation of muramidase activity"}
{"concept_id": "C3894782", "aliases": [], "types": ["T044"], "canonical_name": "activation of N,O-diacetylmuramidase activity"}
{"concept_id": "C3894783", "aliases": [], "types": ["T044"], "canonical_name": "activation of peptidoglycan N-acetylmuramoylhydrolase activity"}
{"concept_id": "C3894784", "aliases": [], "types": ["T044"], "canonical_name": "activation of PR1-lysozyme"}
{"concept_id": "C3894785", "aliases": ["upregulation of globulin G", "up-regulation of globulin G", "up regulation of globulin G"], "types": ["T044"], "canonical_name": "positive regulation of globulin G"}
{"concept_id": "C3894786", "aliases": ["upregulation of globulin G1", "up-regulation of globulin G1", "up regulation of globulin G1"], "types": ["T044"], "canonical_name": "positive regulation of globulin G1"}
{"concept_id": "C3894787", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of L-7001"}
{"concept_id": "C3894788", "aliases": ["up regulation of lysozyme g", "upregulation of lysozyme g", "up-regulation of lysozyme g"], "types": ["T044"], "canonical_name": "positive regulation of lysozyme g"}
{"concept_id": "C3894789", "aliases": ["upregulation of PR1-lysozyme"], "types": ["T044"], "canonical_name": "positive regulation of PR1-lysozyme"}
{"concept_id": "C3894790", "aliases": ["up-regulation of L-7001"], "types": ["T044"], "canonical_name": "up regulation of L-7001"}
{"concept_id": "C3894791", "aliases": ["up-regulation of PR1-lysozyme"], "types": ["T044"], "canonical_name": "up regulation of PR1-lysozyme"}
{"concept_id": "C3894792", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of L-7001"}
{"concept_id": "C3894793", "aliases": [], "types": ["T043"], "canonical_name": "regulation of histamine secretion by mast cell", "definition": "Any process that modulates the frequency, rate or extent of histamine secretion by mast cell. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]"}
{"concept_id": "C3894794", "aliases": ["down regulation of histamine secretion by mast cell", "downregulation of histamine secretion by mast cell", "down-regulation of histamine secretion by mast cell"], "types": ["T043"], "canonical_name": "negative regulation of histamine secretion by mast cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]"}
{"concept_id": "C3894795", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of histamine secretion by mast cell"}
{"concept_id": "C3894796", "aliases": ["up regulation of histamine secretion by mast cell", "up-regulation of histamine secretion by mast cell", "upregulation of histamine secretion by mast cell"], "types": ["T043"], "canonical_name": "positive regulation of histamine secretion by mast cell", "definition": "Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]"}
{"concept_id": "C3894797", "aliases": [], "types": ["T043"], "canonical_name": "activation of histamine secretion by mast cell"}
{"concept_id": "C3894798", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gap junction assembly", "definition": "Any process that modulates the frequency, rate or extent of gap junction assembly. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]"}
{"concept_id": "C3894799", "aliases": ["down-regulation of gap junction assembly", "down regulation of gap junction assembly", "downregulation of gap junction assembly"], "types": ["T043"], "canonical_name": "negative regulation of gap junction assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gap junction assembly. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]"}
{"concept_id": "C3894800", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gap junction assembly"}
{"concept_id": "C3894801", "aliases": ["upregulation of gap junction assembly", "up regulation of gap junction assembly", "up-regulation of gap junction assembly"], "types": ["T043"], "canonical_name": "positive regulation of gap junction assembly", "definition": "Any process that activates or increases the frequency, rate or extent of gap junction assembly. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]"}
{"concept_id": "C3894802", "aliases": [], "types": ["T043"], "canonical_name": "activation of gap junction assembly"}
{"concept_id": "C3894803", "aliases": ["up-regulation of mitophagy", "up-regulation of mitochondrion degradation", "upregulation of mitophagy", "upregulation of mitochondrion degradation", "up regulation of mitochondrion degradation", "up regulation of mitophagy"], "types": ["T043"], "canonical_name": "positive regulation of autophagy of mitochondrion", "definition": "Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy. [GO_REF:0000058, GOC:autophagy, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21753002]"}
{"concept_id": "C3894804", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitochondrion degradation"}
{"concept_id": "C3894805", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitophagy"}
{"concept_id": "C3894806", "aliases": ["glutaminase complex location", "Sno1p-Snz1p"], "types": ["T026"], "canonical_name": "glutaminase complex", "definition": "A protein complex which is capable of glutaminase activity. [GO_REF:0000088, GOC:TermGenie, PMID:14764090]"}
{"concept_id": "C3894807", "aliases": ["thermospermine metabolism"], "types": ["T044"], "canonical_name": "thermospermine metabolic process", "definition": "The chemical reactions and pathways involving thermospermine. [GO_REF:0000068, GOC:TermGenie, PMID:24906355]"}
{"concept_id": "C3894808", "aliases": ["thermospermine degradation", "thermospermine catabolism", "thermospermine breakdown"], "types": ["T044"], "canonical_name": "thermospermine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of thermospermine. [GO_REF:0000068, GOC:TermGenie, PMID:24906355]"}
{"concept_id": "C3894809", "aliases": ["thermospermine formation", "thermospermine anabolism", "thermospermine synthesis", "thermospermine biosynthesis"], "types": ["T044"], "canonical_name": "thermospermine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of thermospermine. [GO_REF:0000068, GOC:TermGenie, PMID:24906355]"}
{"concept_id": "C3894810", "aliases": ["cytochrome metabolism"], "types": ["T044"], "canonical_name": "cytochrome metabolic process", "definition": "The chemical reactions and pathways involving a cytochrome. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]"}
{"concept_id": "C3894811", "aliases": ["cytochrome formation", "cytochrome synthesis", "cytochrome anabolism", "cytochrome biosynthesis"], "types": ["T044"], "canonical_name": "cytochrome biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a cytochrome. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]"}
{"concept_id": "C3894812", "aliases": ["cytochrome c metabolism"], "types": ["T044"], "canonical_name": "cytochrome c metabolic process", "definition": "The chemical reactions and pathways involving cytochrome c. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]"}
{"concept_id": "C3894813", "aliases": ["cytochrome c formation", "cytochrome c synthesis", "cytochrome c anabolism", "cytochrome c biosynthesis"], "types": ["T044"], "canonical_name": "cytochrome c biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cytochrome c. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]"}
{"concept_id": "C3894814", "aliases": ["protein localization in cytoplasmic stress granule", "protein localisation in cytoplasmic stress granule", "protein localisation to cytoplasmic stress granule"], "types": ["T043"], "canonical_name": "protein localization to cytoplasmic stress granule", "definition": "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule. [GO_REF:0000087, GOC:TermGenie, PMID:24755092]"}
{"concept_id": "C3894815", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to stress granule"}
{"concept_id": "C3894816", "aliases": ["down regulation of Kir channel activity", "downregulation of Kir channel activity", "down-regulation of Kir channel activity", "negative regulation of Kir channel activity", "down regulation of inward rectifier potassium channel activity", "down-regulation of inward rectifier potassium channel activity", "downregulation of inward rectifier potassium channel activity"], "types": ["T044"], "canonical_name": "negative regulation of inward rectifier potassium channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18923542]"}
{"concept_id": "C3894817", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of Kir channel activity"}
{"concept_id": "C3894818", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcium-dependent ATPase activity", "definition": "Any process that modulates the frequency, rate or extent of calcium-dependent ATPase activity. [GO_REF:0000059, GOC:TermGenie, PMID:10861851]"}
{"concept_id": "C3894819", "aliases": ["downregulation of calcium-dependent ATPase activity", "down-regulation of calcium-dependent ATPase activity", "down regulation of calcium-dependent ATPase activity"], "types": ["T044"], "canonical_name": "negative regulation of calcium-dependent ATPase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent ATPase activity. [GO_REF:0000059, GOC:TermGenie, PMID:10861851]"}
{"concept_id": "C3894820", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcium-dependent ATPase activity"}
{"concept_id": "C3894821", "aliases": ["up-regulation of calcium-dependent ATPase activity", "up regulation of calcium-dependent ATPase activity", "upregulation of calcium-dependent ATPase activity"], "types": ["T044"], "canonical_name": "positive regulation of calcium-dependent ATPase activity", "definition": "Any process that activates or increases the frequency, rate or extent of calcium-dependent ATPase activity. [GO_REF:0000059, GOC:TermGenie, PMID:10861851]"}
{"concept_id": "C3894822", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcium-dependent ATPase activity"}
{"concept_id": "C3894823", "aliases": ["regulation of [phosphotyrosine]protein phosphatase activity", "regulation of PTP-phosphatase activity", "regulation of phosphotyrosine histone phosphatase activity", "regulation of phosphotyrosylprotein phosphatase activity", "regulation of phosphoprotein phosphatase (phosphotyrosine) activity", "regulation of phosphotyrosine protein phosphatase activity", "regulation of protein-tyrosine-phosphatase activity", "regulation of protein-tyrosine-phosphate phosphohydrolase activity", "regulation of PTPase activity", "regulation of PPT-phosphatase activity", "regulation of tyrosylprotein phosphatase activity", "regulation of tyrosine O-phosphate phosphatase activity", "regulation of protein phosphotyrosine phosphatase activity", "regulation of phosphotyrosine phosphatase activity"], "types": ["T044"], "canonical_name": "regulation of protein tyrosine phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of protein tyrosine phosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:11129957]"}
{"concept_id": "C3894824", "aliases": ["negative regulation of [phosphotyrosine]protein phosphatase activity", "down-regulation of tyrosine O-phosphate phosphatase activity", "negative regulation of phosphotyrosylprotein phosphatase activity", "downregulation of tyrosine O-phosphate phosphatase activity", "down-regulation of phosphotyrosine histone phosphatase activity", "negative regulation of phosphotyrosine protein phosphatase activity", "down-regulation of phosphotyrosine protein phosphatase activity", "down regulation of [phosphotyrosine]protein phosphatase activity", "down-regulation of PTPase activity", "down-regulation of phosphoprotein phosphatase (phosphotyrosine) activity", "downregulation of [phosphotyrosine]protein phosphatase activity", "down-regulation of protein phosphotyrosine phosphatase activity", "down regulation of PTP-phosphatase activity", "negative regulation of phosphotyrosine phosphatase activity", "down regulation of phosphotyrosine histone phosphatase activity", "negative regulation of PPT-phosphatase activity", "negative regulation of protein phosphotyrosine phosphatase activity", "negative regulation of tyrosine O-phosphate phosphatase activity", "down regulation of PTPase activity", "down regulation of phosphoprotein phosphatase (phosphotyrosine) activity", "negative regulation of phosphoprotein phosphatase (phosphotyrosine) activity", "down-regulation of [phosphotyrosine]protein phosphatase activity", "down regulation of tyrosine O-phosphate phosphatase activity", "downregulation of phosphotyrosine protein phosphatase activity", "downregulation of protein tyrosine phosphatase activity", "negative regulation of protein-tyrosine-phosphatase activity", "down-regulation of protein tyrosine phosphatase activity", "down regulation of phosphotyrosine protein phosphatase activity", "downregulation of phosphotyrosine phosphatase activity", "down-regulation of tyrosylprotein phosphatase activity", "down regulation of phosphotyrosine phosphatase activity", "downregulation of PTP-phosphatase activity", "down regulation of PPT-phosphatase activity", "downregulation of tyrosylprotein phosphatase activity", "downregulation of PTPase activity", "down-regulation of phosphotyrosylprotein phosphatase activity", "negative regulation of protein-tyrosine-phosphate phosphohydrolase activity", "downregulation of phosphotyrosine histone phosphatase activity", "down regulation of protein-tyrosine-phosphatase activity", "downregulation of phosphotyrosylprotein phosphatase activity", "down-regulation of PPT-phosphatase activity", "negative regulation of PTP-phosphatase activity", "negative regulation of PTPase activity", "down regulation of phosphotyrosylprotein phosphatase activity", "down regulation of protein phosphotyrosine phosphatase activity", "down regulation of protein-tyrosine-phosphate phosphohydrolase activity", "down-regulation of protein-tyrosine-phosphatase activity", "downregulation of protein phosphotyrosine phosphatase activity", "down regulation of protein tyrosine phosphatase activity", "down-regulation of PTP-phosphatase activity", "downregulation of protein-tyrosine-phosphatase activity", "down-regulation of phosphotyrosine phosphatase activity", "downregulation of protein-tyrosine-phosphate phosphohydrolase activity", "negative regulation of tyrosylprotein phosphatase activity", "down-regulation of protein-tyrosine-phosphate phosphohydrolase activity", "negative regulation of phosphotyrosine histone phosphatase activity", "downregulation of PPT-phosphatase activity", "downregulation of phosphoprotein phosphatase (phosphotyrosine) activity", "down regulation of tyrosylprotein phosphatase activity"], "types": ["T044"], "canonical_name": "negative regulation of protein tyrosine phosphatase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:11129957]"}
{"concept_id": "C3894825", "aliases": ["inhibition of phosphotyrosine protein phosphatase activity", "inhibition of protein phosphotyrosine phosphatase activity"], "types": ["T044"], "canonical_name": "inhibition of [phosphotyrosine]protein phosphatase activity"}
{"concept_id": "C3894826", "aliases": ["inhibition of phosphoprotein phosphatase (phosphotyrosine) activity", "inhibition of phosphotyrosine histone phosphatase activity", "inhibition of PTP-phosphatase activity", "inhibition of tyrosylprotein phosphatase activity", "inhibition of protein-tyrosine-phosphatase activity", "inhibition of PTPase activity", "inhibition of tyrosine O-phosphate phosphatase activity", "inhibition of protein-tyrosine-phosphate phosphohydrolase activity", "inhibition of protein tyrosine phosphatase activity", "inhibition of phosphotyrosylprotein phosphatase activity", "inhibition of phosphotyrosine phosphatase activity"], "types": ["T044"], "canonical_name": "inhibition of PPT-phosphatase activity"}
{"concept_id": "C3894827", "aliases": ["positive regulation of PTP-phosphatase activity", "up-regulation of phosphotyrosine protein phosphatase activity", "positive regulation of phosphoprotein phosphatase (phosphotyrosine) activity", "up regulation of phosphotyrosine protein phosphatase activity", "positive regulation of phosphotyrosine protein phosphatase activity", "up-regulation of [phosphotyrosine]protein phosphatase activity", "up-regulation of phosphotyrosine phosphatase activity", "positive regulation of [phosphotyrosine]protein phosphatase activity", "up-regulation of phosphotyrosylprotein phosphatase activity", "up-regulation of protein-tyrosine-phosphatase activity", "positive regulation of phosphotyrosine histone phosphatase activity", "up regulation of [phosphotyrosine]protein phosphatase activity", "upregulation of phosphotyrosine protein phosphatase activity", "upregulation of protein phosphotyrosine phosphatase activity", "up regulation of PTP-phosphatase activity", "up-regulation of phosphotyrosine histone phosphatase activity", "up regulation of PPT-phosphatase activity", "positive regulation of protein phosphotyrosine phosphatase activity", "positive regulation of tyrosine O-phosphate phosphatase activity", "positive regulation of tyrosylprotein phosphatase activity", "up regulation of tyrosine O-phosphate phosphatase activity", "up regulation of protein tyrosine phosphatase activity", "positive regulation of phosphotyrosine phosphatase activity", "up regulation of phosphotyrosylprotein phosphatase activity", "up-regulation of protein-tyrosine-phosphate phosphohydrolase activity", "up regulation of phosphotyrosine histone phosphatase activity", "upregulation of tyrosylprotein phosphatase activity", "upregulation of protein-tyrosine-phosphatase activity", "upregulation of phosphotyrosine phosphatase activity", "up-regulation of PTP-phosphatase activity", "upregulation of PTP-phosphatase activity", "up-regulation of tyrosylprotein phosphatase activity", "up-regulation of phosphoprotein phosphatase (phosphotyrosine) activity", "up-regulation of protein tyrosine phosphatase activity", "upregulation of PPT-phosphatase activity", "positive regulation of protein-tyrosine-phosphate phosphohydrolase activity", "up-regulation of PTPase activity", "upregulation of [phosphotyrosine]protein phosphatase activity", "upregulation of phosphotyrosine histone phosphatase activity", "upregulation of PTPase activity", "upregulation of protein tyrosine phosphatase activity", "up regulation of protein-tyrosine-phosphate phosphohydrolase activity", "up regulation of protein-tyrosine-phosphatase activity", "upregulation of protein-tyrosine-phosphate phosphohydrolase activity", "up-regulation of protein phosphotyrosine phosphatase activity", "upregulation of tyrosine O-phosphate phosphatase activity", "upregulation of phosphoprotein phosphatase (phosphotyrosine) activity", "up regulation of protein phosphotyrosine phosphatase activity", "positive regulation of PTPase activity", "upregulation of phosphotyrosylprotein phosphatase activity", "up-regulation of PPT-phosphatase activity", "up regulation of phosphoprotein phosphatase (phosphotyrosine) activity", "positive regulation of phosphotyrosylprotein phosphatase activity", "positive regulation of protein-tyrosine-phosphatase activity", "up regulation of tyrosylprotein phosphatase activity", "up-regulation of tyrosine O-phosphate phosphatase activity", "up regulation of PTPase activity", "up regulation of phosphotyrosine phosphatase activity", "positive regulation of PPT-phosphatase activity"], "types": ["T044"], "canonical_name": "positive regulation of protein tyrosine phosphatase activity", "definition": "Any process that activates or increases the frequency, rate or extent of protein tyrosine phosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:11129957]"}
{"concept_id": "C3894828", "aliases": ["activation of phosphotyrosine protein phosphatase activity", "activation of protein phosphotyrosine phosphatase activity"], "types": ["T044"], "canonical_name": "activation of [phosphotyrosine]protein phosphatase activity"}
{"concept_id": "C3894829", "aliases": ["activation of phosphoprotein phosphatase (phosphotyrosine) activity", "activation of PTPase activity", "activation of phosphotyrosine phosphatase activity", "activation of tyrosine O-phosphate phosphatase activity", "activation of protein-tyrosine-phosphatase activity", "activation of PTP-phosphatase activity", "activation of tyrosylprotein phosphatase activity", "activation of phosphotyrosine histone phosphatase activity", "activation of phosphotyrosylprotein phosphatase activity", "activation of protein-tyrosine-phosphate phosphohydrolase activity", "activation of protein tyrosine phosphatase activity"], "types": ["T044"], "canonical_name": "activation of PPT-phosphatase activity"}
{"concept_id": "C3894834", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic cytokinesis, site selection", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis, site selection. [GO_REF:0000058, GOC:TermGenie, PMID:21246752]"}
{"concept_id": "C3894835", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transdifferentiation", "definition": "Any process that modulates the frequency, rate or extent of transdifferentiation. [GO_REF:0000058, GOC:TermGenie, PMID:22118091]"}
{"concept_id": "C3894836", "aliases": ["down regulation of transdifferentiation", "down-regulation of transdifferentiation", "downregulation of transdifferentiation"], "types": ["T043"], "canonical_name": "negative regulation of transdifferentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transdifferentiation. [GO_REF:0000058, GOC:TermGenie, PMID:22118091]"}
{"concept_id": "C3894837", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of transdifferentiation"}
{"concept_id": "C3894838", "aliases": ["up regulation of transdifferentiation", "upregulation of transdifferentiation", "up-regulation of transdifferentiation"], "types": ["T043"], "canonical_name": "positive regulation of transdifferentiation", "definition": "Any process that activates or increases the frequency, rate or extent of transdifferentiation. [GO_REF:0000058, GOC:TermGenie, PMID:22118091]"}
{"concept_id": "C3894839", "aliases": [], "types": ["T043"], "canonical_name": "activation of transdifferentiation"}
{"concept_id": "C3894840", "aliases": ["protein localization in photoreceptor connecting cilium", "protein localisation in photoreceptor connecting cilium", "protein localisation to photoreceptor connecting cilium"], "types": ["T043"], "canonical_name": "protein localization to photoreceptor connecting cilium", "definition": "A process in which a protein is transported to, or maintained in, a location within a photoreceptor connecting cilium. [GO_REF:0000087, GOC:lb, GOC:TermGenie, PMID:25398945]"}
{"concept_id": "C3894841", "aliases": [], "types": ["T045"], "canonical_name": "regulation of RNA polymerase III activity", "definition": "Any process that modulates the frequency, rate or extent of RNA polymerase III activity. [GO_REF:0000059, GOC:TermGenie, PMID:25392932]"}
{"concept_id": "C3894842", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter"}
{"concept_id": "C3894843", "aliases": ["down-regulation of RNA polymerase III activity", "downregulation of RNA polymerase III activity", "down regulation of RNA polymerase III activity", "negative regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter", "down regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter", "down-regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter", "downregulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter"], "types": ["T045"], "canonical_name": "negative regulation of RNA polymerase III activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity. [GO_REF:0000059, GOC:TermGenie, PMID:25392932]"}
{"concept_id": "C3894844", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter"}
{"concept_id": "C3894845", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of RNA polymerase III activity"}
{"concept_id": "C3894846", "aliases": ["regulation of DNA breakdown", "regulation of DNA degradation", "regulation of DNA catabolism"], "types": ["T044"], "canonical_name": "regulation of DNA catabolic process", "definition": "Any process that modulates the frequency, rate or extent of DNA catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:2001740]"}
{"concept_id": "C3894847", "aliases": ["negative regulation of DNA catabolism", "downregulation of DNA catabolism", "down regulation of DNA catabolic process", "down regulation of DNA catabolism", "down-regulation of DNA degradation", "negative regulation of DNA breakdown", "downregulation of DNA degradation", "down regulation of DNA breakdown", "downregulation of DNA catabolic process", "down-regulation of DNA catabolism", "down-regulation of DNA breakdown", "down-regulation of DNA catabolic process", "down regulation of DNA degradation", "negative regulation of DNA degradation", "downregulation of DNA breakdown"], "types": ["T044"], "canonical_name": "negative regulation of DNA catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:2001740]"}
{"concept_id": "C3894848", "aliases": ["inhibition of DNA catabolic process", "inhibition of DNA degradation", "inhibition of DNA catabolism"], "types": ["T044"], "canonical_name": "inhibition of DNA breakdown"}
{"concept_id": "C3894849", "aliases": ["up regulation of DNA catabolic process", "up regulation of DNA breakdown", "up regulation of DNA degradation", "positive regulation of DNA catabolism", "upregulation of DNA catabolic process", "upregulation of DNA catabolism", "positive regulation of DNA degradation", "upregulation of DNA breakdown", "up-regulation of DNA breakdown", "upregulation of DNA degradation", "up-regulation of DNA catabolism", "up regulation of DNA catabolism", "up-regulation of DNA degradation", "positive regulation of DNA breakdown", "up-regulation of DNA catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of DNA catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of DNA catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:2001740]"}
{"concept_id": "C3894850", "aliases": ["activation of DNA degradation", "activation of DNA catabolic process", "activation of DNA catabolism"], "types": ["T044"], "canonical_name": "activation of DNA breakdown"}
{"concept_id": "C3894851", "aliases": ["regulation of desoxyuridine 5'-triphosphatase activity", "regulation of dUTP nucleotidohydrolase activity", "regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "regulation of deoxyuridine-triphosphatase activity", "regulation of dUTP pyrophosphatase activity", "regulation of dUTPase activity"], "types": ["T044"], "canonical_name": "regulation of dUTP diphosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of dUTP diphosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:1315924]"}
{"concept_id": "C3894852", "aliases": ["negative regulation of dUTPase activity", "down regulation of dUTP nucleotidohydrolase activity", "down regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "downregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "downregulation of dUTP nucleotidohydrolase activity", "negative regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "down-regulation of dUTP diphosphatase activity", "down regulation of dUTPase activity", "downregulation of dUTP diphosphatase activity", "downregulation of desoxyuridine 5'-triphosphatase activity", "down-regulation of desoxyuridine 5'-triphosphatase activity", "downregulation of deoxyuridine-triphosphatase activity", "downregulation of dUTP pyrophosphatase activity", "down regulation of dUTP pyrophosphatase activity", "down regulation of deoxyuridine-triphosphatase activity", "down-regulation of dUTPase activity", "negative regulation of deoxyuridine-triphosphatase activity", "negative regulation of desoxyuridine 5'-triphosphatase activity", "downregulation of dUTPase activity", "down-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "down regulation of dUTP diphosphatase activity", "down-regulation of dUTP pyrophosphatase activity", "down-regulation of dUTP nucleotidohydrolase activity", "negative regulation of dUTP pyrophosphatase activity", "negative regulation of dUTP nucleotidohydrolase activity", "down regulation of desoxyuridine 5'-triphosphatase activity", "down-regulation of deoxyuridine-triphosphatase activity"], "types": ["T044"], "canonical_name": "negative regulation of dUTP diphosphatase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dUTP diphosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:1315924]"}
{"concept_id": "C3894853", "aliases": ["inhibition of dUTPase activity", "inhibition of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "inhibition of dUTP pyrophosphatase activity", "inhibition of deoxyuridine-triphosphatase activity", "inhibition of desoxyuridine 5'-triphosphatase activity", "inhibition of dUTP nucleotidohydrolase activity"], "types": ["T044"], "canonical_name": "inhibition of dUTP diphosphatase activity"}
{"concept_id": "C3894854", "aliases": ["up-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "positive regulation of dUTPase activity", "up regulation of deoxyuridine-triphosphatase activity", "positive regulation of dUTP nucleotidohydrolase activity", "up regulation of dUTP diphosphatase activity", "up-regulation of dUTP nucleotidohydrolase activity", "positive regulation of deoxyuridine-triphosphatase activity", "positive regulation of dUTP pyrophosphatase activity", "up-regulation of dUTPase activity", "up regulation of dUTPase activity", "upregulation of deoxyuridine-triphosphatase activity", "upregulation of dUTP pyrophosphatase activity", "up regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "upregulation of dUTPase activity", "up-regulation of deoxyuridine-triphosphatase activity", "up regulation of desoxyuridine 5'-triphosphatase activity", "up-regulation of dUTP pyrophosphatase activity", "positive regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "upregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "upregulation of dUTP diphosphatase activity", "up regulation of dUTP nucleotidohydrolase activity", "up-regulation of desoxyuridine 5'-triphosphatase activity", "up regulation of dUTP pyrophosphatase activity", "upregulation of desoxyuridine 5'-triphosphatase activity", "positive regulation of desoxyuridine 5'-triphosphatase activity", "up-regulation of dUTP diphosphatase activity", "upregulation of dUTP nucleotidohydrolase activity"], "types": ["T044"], "canonical_name": "positive regulation of dUTP diphosphatase activity", "definition": "Any process that activates or increases the frequency, rate or extent of dUTP diphosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:1315924]"}
{"concept_id": "C3894855", "aliases": ["activation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity", "activation of deoxyuridine-triphosphatase activity", "activation of dUTP nucleotidohydrolase activity", "activation of dUTP pyrophosphatase activity", "activation of dUTPase activity", "activation of desoxyuridine 5'-triphosphatase activity"], "types": ["T044"], "canonical_name": "activation of dUTP diphosphatase activity"}
{"concept_id": "C3894856", "aliases": ["regulation of aminoacyl-tRNA synthetase activity"], "types": ["T044"], "canonical_name": "regulation of aminoacyl-tRNA ligase activity", "definition": "Any process that modulates the frequency, rate or extent of aminoacyl-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:2280766]"}
{"concept_id": "C3894857", "aliases": [], "types": ["T044"], "canonical_name": "regulation of aminoacyl-tRNA synthetase auxiliary protein activity"}
{"concept_id": "C3894858", "aliases": ["down regulation of aminoacyl-tRNA ligase activity", "negative regulation of aminoacyl-tRNA synthetase activity", "down-regulation of aminoacyl-tRNA synthetase activity", "downregulation of aminoacyl-tRNA ligase activity", "down regulation of aminoacyl-tRNA synthetase activity", "down-regulation of aminoacyl-tRNA ligase activity", "downregulation of aminoacyl-tRNA synthetase activity"], "types": ["T044"], "canonical_name": "negative regulation of aminoacyl-tRNA ligase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aminoacyl-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:2280766]"}
{"concept_id": "C3894859", "aliases": ["down-regulation of aminoacyl-tRNA synthetase auxiliary protein activity"], "types": ["T044"], "canonical_name": "down regulation of aminoacyl-tRNA synthetase auxiliary protein activity"}
{"concept_id": "C3894860", "aliases": [], "types": ["T044"], "canonical_name": "downregulation of aminoacyl-tRNA synthetase auxiliary protein activity"}
{"concept_id": "C3894861", "aliases": ["inhibition of aminoacyl-tRNA synthetase activity"], "types": ["T044"], "canonical_name": "inhibition of aminoacyl-tRNA ligase activity"}
{"concept_id": "C3894862", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aminoacyl-tRNA synthetase auxiliary protein activity"}
{"concept_id": "C3894863", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of aminoacyl-tRNA synthetase auxiliary protein activity"}
{"concept_id": "C3894864", "aliases": ["up-regulation of aminoacyl-tRNA ligase activity", "up-regulation of aminoacyl-tRNA synthetase activity", "upregulation of aminoacyl-tRNA ligase activity", "upregulation of aminoacyl-tRNA synthetase activity", "positive regulation of aminoacyl-tRNA synthetase activity", "up regulation of aminoacyl-tRNA synthetase activity", "up regulation of aminoacyl-tRNA ligase activity"], "types": ["T044"], "canonical_name": "positive regulation of aminoacyl-tRNA ligase activity", "definition": "Any process that activates or increases the frequency, rate or extent of aminoacyl-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:2280766]"}
{"concept_id": "C3894865", "aliases": ["activation of aminoacyl-tRNA synthetase activity"], "types": ["T044"], "canonical_name": "activation of aminoacyl-tRNA ligase activity"}
{"concept_id": "C3894866", "aliases": [], "types": ["T044"], "canonical_name": "activation of aminoacyl-tRNA synthetase auxiliary protein activity"}
{"concept_id": "C3894867", "aliases": ["upregulation of aminoacyl-tRNA synthetase auxiliary protein activity"], "types": ["T044"], "canonical_name": "positive regulation of aminoacyl-tRNA synthetase auxiliary protein activity"}
{"concept_id": "C3894868", "aliases": ["up-regulation of aminoacyl-tRNA synthetase auxiliary protein activity"], "types": ["T044"], "canonical_name": "up regulation of aminoacyl-tRNA synthetase auxiliary protein activity"}
{"concept_id": "C3894869", "aliases": ["regulation of leucine-tRNA synthetase activity", "regulation of leucyl-transfer ribonucleate synthetase activity", "regulation of L-leucine:tRNALeu ligase (AMP-forming)", "regulation of leucyl-tRNA synthetase activity", "regulation of leucine translase activity", "regulation of leucyl-transfer ribonucleic acid synthetase activity", "regulation of leucyl-transfer RNA synthetase activity"], "types": ["T044"], "canonical_name": "regulation of leucine-tRNA ligase activity", "definition": "Any process that modulates the frequency, rate or extent of leucine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:2280766]"}
{"concept_id": "C3894870", "aliases": ["down-regulation of leucine-tRNA ligase activity", "down-regulation of leucine-tRNA synthetase activity", "negative regulation of leucine-tRNA synthetase activity", "down regulation of leucyl-transfer ribonucleic acid synthetase activity", "downregulation of leucyl-tRNA synthetase activity", "down regulation of leucine-tRNA ligase activity", "down-regulation of leucine translase activity", "down-regulation of leucyl-transfer ribonucleate synthetase activity", "negative regulation of leucyl-transfer ribonucleic acid synthetase activity", "negative regulation of leucyl-transfer RNA synthetase activity", "downregulation of leucyl-transfer ribonucleate synthetase activity", "downregulation of leucyl-transfer ribonucleic acid synthetase activity", "negative regulation of leucyl-transfer ribonucleate synthetase activity", "down regulation of leucine-tRNA synthetase activity", "down regulation of leucyl-tRNA synthetase activity", "down regulation of leucyl-transfer RNA synthetase activity", "downregulation of leucine-tRNA ligase activity", "down-regulation of L-leucine:tRNALeu ligase (AMP-forming)", "down-regulation of leucyl-transfer ribonucleic acid synthetase activity", "down regulation of leucyl-transfer ribonucleate synthetase activity", "down-regulation of leucyl-tRNA synthetase activity", "downregulation of leucine-tRNA synthetase activity", "downregulation of leucyl-transfer RNA synthetase activity", "negative regulation of leucyl-tRNA synthetase activity", "negative regulation of leucine translase activity", "down-regulation of leucyl-transfer RNA synthetase activity", "downregulation of L-leucine:tRNALeu ligase (AMP-forming)", "negative regulation of L-leucine:tRNALeu ligase (AMP-forming)", "downregulation of leucine translase activity", "down regulation of L-leucine:tRNALeu ligase (AMP-forming)", "down regulation of leucine translase activity"], "types": ["T044"], "canonical_name": "negative regulation of leucine-tRNA ligase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leucine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:2280766]"}
{"concept_id": "C3894871", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-leucine:tRNALeu ligase (AMP-forming)"}
{"concept_id": "C3894872", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of leucine translase activity"}
{"concept_id": "C3894873", "aliases": ["inhibition of leucyl-transfer ribonucleic acid synthetase activity", "inhibition of leucyl-transfer RNA synthetase activity", "inhibition of leucyl-tRNA synthetase activity", "inhibition of leucine-tRNA synthetase activity", "inhibition of leucyl-transfer ribonucleate synthetase activity"], "types": ["T044"], "canonical_name": "inhibition of leucine-tRNA ligase activity"}
{"concept_id": "C3894874", "aliases": ["up-regulation of leucyl-transfer ribonucleic acid synthetase activity", "upregulation of leucyl-tRNA synthetase activity", "up regulation of leucyl-transfer ribonucleate synthetase activity", "up-regulation of leucine-tRNA ligase activity", "up regulation of leucyl-transfer ribonucleic acid synthetase activity", "up-regulation of L-leucine:tRNALeu ligase (AMP-forming)", "positive regulation of leucyl-transfer ribonucleic acid synthetase activity", "positive regulation of leucine-tRNA synthetase activity", "positive regulation of leucyl-transfer RNA synthetase activity", "up regulation of leucyl-tRNA synthetase activity", "up-regulation of leucine-tRNA synthetase activity", "upregulation of leucine translase activity", "positive regulation of leucine translase activity", "up-regulation of leucine translase activity", "up-regulation of leucyl-tRNA synthetase activity", "upregulation of L-leucine:tRNALeu ligase (AMP-forming)", "upregulation of leucyl-transfer RNA synthetase activity", "up regulation of leucine-tRNA synthetase activity", "positive regulation of leucyl-tRNA synthetase activity", "positive regulation of L-leucine:tRNALeu ligase (AMP-forming)", "up regulation of leucine translase activity", "upregulation of leucyl-transfer ribonucleic acid synthetase activity", "up-regulation of leucyl-transfer ribonucleate synthetase activity", "positive regulation of leucyl-transfer ribonucleate synthetase activity", "up regulation of leucyl-transfer RNA synthetase activity", "up-regulation of leucyl-transfer RNA synthetase activity", "up regulation of leucine-tRNA ligase activity", "upregulation of leucine-tRNA ligase activity", "up regulation of L-leucine:tRNALeu ligase (AMP-forming)", "upregulation of leucyl-transfer ribonucleate synthetase activity", "upregulation of leucine-tRNA synthetase activity"], "types": ["T044"], "canonical_name": "positive regulation of leucine-tRNA ligase activity", "definition": "Any process that activates or increases the frequency, rate or extent of leucine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:2280766]"}
{"concept_id": "C3894875", "aliases": ["activation of leucine-tRNA ligase activity", "activation of leucyl-tRNA synthetase activity", "activation of leucyl-transfer RNA synthetase activity", "activation of leucine-tRNA synthetase activity", "activation of leucine translase activity", "activation of leucyl-transfer ribonucleic acid synthetase activity", "activation of leucyl-transfer ribonucleate synthetase activity"], "types": ["T044"], "canonical_name": "activation of L-leucine:tRNALeu ligase (AMP-forming)"}
{"concept_id": "C3894876", "aliases": ["regulation of mitochondrial outer membrane protein import", "regulation of protein transport into mitochondrial outer membrane", "regulation of protein import into mitochondrial outer membrane"], "types": ["T043"], "canonical_name": "regulation of protein insertion into mitochondrial outer membrane", "definition": "Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial outer membrane. [GO_REF:0000058, GOC:TermGenie, PMID:16374546]"}
{"concept_id": "C3894877", "aliases": ["down regulation of protein transport into mitochondrial outer membrane", "negative regulation of protein import into mitochondrial outer membrane", "downregulation of protein import into mitochondrial outer membrane", "downregulation of protein transport into mitochondrial outer membrane", "down-regulation of mitochondrial outer membrane protein import", "negative regulation of mitochondrial outer membrane protein import", "down regulation of protein insertion into mitochondrial outer membrane", "down regulation of mitochondrial outer membrane protein import", "downregulation of mitochondrial outer membrane protein import", "downregulation of protein insertion into mitochondrial outer membrane", "negative regulation of protein transport into mitochondrial outer membrane", "down regulation of protein import into mitochondrial outer membrane", "down-regulation of protein transport into mitochondrial outer membrane", "down-regulation of protein insertion into mitochondrial outer membrane", "down-regulation of protein import into mitochondrial outer membrane"], "types": ["T043"], "canonical_name": "negative regulation of protein insertion into mitochondrial outer membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein insertion into mitochondrial outer membrane. [GO_REF:0000058, GOC:TermGenie, PMID:16374546]"}
{"concept_id": "C3894878", "aliases": ["inhibition of protein transport into mitochondrial outer membrane", "inhibition of protein insertion into mitochondrial outer membrane", "inhibition of protein import into mitochondrial outer membrane"], "types": ["T043"], "canonical_name": "inhibition of mitochondrial outer membrane protein import"}
{"concept_id": "C3894879", "aliases": ["upregulation of protein insertion into mitochondrial outer membrane", "up regulation of mitochondrial outer membrane protein import", "up-regulation of protein import into mitochondrial outer membrane", "upregulation of protein transport into mitochondrial outer membrane", "upregulation of protein import into mitochondrial outer membrane", "positive regulation of protein transport into mitochondrial outer membrane", "positive regulation of protein import into mitochondrial outer membrane", "upregulation of mitochondrial outer membrane protein import", "up-regulation of protein insertion into mitochondrial outer membrane", "up regulation of protein import into mitochondrial outer membrane", "up-regulation of protein transport into mitochondrial outer membrane", "positive regulation of mitochondrial outer membrane protein import", "up-regulation of mitochondrial outer membrane protein import", "up regulation of protein transport into mitochondrial outer membrane", "up regulation of protein insertion into mitochondrial outer membrane"], "types": ["T043"], "canonical_name": "positive regulation of protein insertion into mitochondrial outer membrane", "definition": "Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial outer membrane. [GO_REF:0000058, GOC:TermGenie, PMID:16374546]"}
{"concept_id": "C3894880", "aliases": ["activation of protein transport into mitochondrial outer membrane", "activation of protein import into mitochondrial outer membrane", "activation of protein insertion into mitochondrial outer membrane"], "types": ["T043"], "canonical_name": "activation of mitochondrial outer membrane protein import"}
{"concept_id": "C3894881", "aliases": [], "types": ["T038"], "canonical_name": "regulation of gastrin-induced gastric acid secretion", "definition": "Any process that modulates the frequency, rate or extent of gastrin-induced gastric acid secretion. [GO_REF:0000058, GOC:TermGenie, PMID:11123201]"}
{"concept_id": "C3894882", "aliases": ["down regulation of gastrin-induced gastric acid secretion", "down-regulation of gastrin-induced gastric acid secretion", "downregulation of gastrin-induced gastric acid secretion"], "types": ["T038"], "canonical_name": "negative regulation of gastrin-induced gastric acid secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion. [GO_REF:0000058, GOC:TermGenie, PMID:11123201]"}
{"concept_id": "C3894883", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of gastrin-induced gastric acid secretion"}
{"concept_id": "C3894884", "aliases": ["upregulation of gastrin-induced gastric acid secretion", "up-regulation of gastrin-induced gastric acid secretion", "up regulation of gastrin-induced gastric acid secretion"], "types": ["T038"], "canonical_name": "positive regulation of gastrin-induced gastric acid secretion", "definition": "Any process that activates or increases the frequency, rate or extent of gastrin-induced gastric acid secretion. [GO_REF:0000058, GOC:TermGenie, PMID:11123201]"}
{"concept_id": "C3894885", "aliases": [], "types": ["T038"], "canonical_name": "activation of gastrin-induced gastric acid secretion"}
{"concept_id": "C3894886", "aliases": ["regulation of DNA binding, recombination hotspot"], "types": ["T045"], "canonical_name": "regulation of recombination hotspot binding", "definition": "Any process that modulates the frequency, rate or extent of recombination hotspot binding. [GO_REF:0000059, GOC:TermGenie, PMID:19436749]"}
{"concept_id": "C3894887", "aliases": ["positive regulation of DNA binding, recombination hotspot", "up-regulation of DNA binding, recombination hotspot", "upregulation of DNA binding, recombination hotspot", "up-regulation of recombination hotspot binding", "up regulation of recombination hotspot binding", "upregulation of recombination hotspot binding", "up regulation of DNA binding, recombination hotspot"], "types": ["T044"], "canonical_name": "positive regulation of recombination hotspot binding", "definition": "Any process that activates or increases the frequency, rate or extent of recombination hotspot binding. [GO_REF:0000059, GOC:TermGenie, PMID:19436749]"}
{"concept_id": "C3894888", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA binding, recombination hotspot"}
{"concept_id": "C3894889", "aliases": [], "types": ["T044"], "canonical_name": "activation of recombination hotspot binding"}
{"concept_id": "C3894890", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chaperone-mediated protein folding", "definition": "Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding. [GO_REF:0000058, GOC:TermGenie, PMID:24375412]"}
{"concept_id": "C3894891", "aliases": ["down regulation of chaperone-mediated protein folding", "downregulation of chaperone-mediated protein folding", "down-regulation of chaperone-mediated protein folding"], "types": ["T044"], "canonical_name": "negative regulation of chaperone-mediated protein folding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding. [GO_REF:0000058, GOC:TermGenie, PMID:24375412]"}
{"concept_id": "C3894892", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of chaperone-mediated protein folding"}
{"concept_id": "C3894893", "aliases": ["up regulation of chaperone-mediated protein folding", "up-regulation of chaperone-mediated protein folding", "upregulation of chaperone-mediated protein folding"], "types": ["T044"], "canonical_name": "positive regulation of chaperone-mediated protein folding", "definition": "Any process that activates or increases the frequency, rate or extent of chaperone-mediated protein folding. [GO_REF:0000058, GOC:TermGenie, PMID:24375412]"}
{"concept_id": "C3894894", "aliases": [], "types": ["T044"], "canonical_name": "activation of chaperone-mediated protein folding"}
{"concept_id": "C3894895", "aliases": ["downregulation of chlorophyll catabolism", "down-regulation of chlorophyll degradation", "negative regulation of chlorophyll catabolism", "negative regulation of chlorophyll degradation", "downregulation of chlorophyll degradation", "negative regulation of chlorophyll breakdown", "down regulation of chlorophyll catabolism", "down regulation of chlorophyll degradation", "down regulation of chlorophyll catabolic process", "down regulation of chlorophyll breakdown", "down-regulation of chlorophyll breakdown", "down-regulation of chlorophyll catabolism", "down-regulation of chlorophyll catabolic process", "downregulation of chlorophyll catabolic process", "downregulation of chlorophyll breakdown"], "types": ["T044"], "canonical_name": "negative regulation of chlorophyll catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:24719469]"}
{"concept_id": "C3894896", "aliases": ["inhibition of chlorophyll degradation", "inhibition of chlorophyll catabolic process", "inhibition of chlorophyll catabolism"], "types": ["T044"], "canonical_name": "inhibition of chlorophyll breakdown"}
{"concept_id": "C3894897", "aliases": ["positive regulation of chlorophyll breakdown", "up-regulation of chlorophyll degradation", "up regulation of chlorophyll degradation", "up regulation of chlorophyll breakdown", "upregulation of chlorophyll degradation", "up-regulation of chlorophyll catabolic process", "upregulation of chlorophyll catabolism", "upregulation of chlorophyll catabolic process", "positive regulation of chlorophyll degradation", "up regulation of chlorophyll catabolism", "up regulation of chlorophyll catabolic process", "up-regulation of chlorophyll catabolism", "up-regulation of chlorophyll breakdown", "positive regulation of chlorophyll catabolism", "upregulation of chlorophyll breakdown"], "types": ["T044"], "canonical_name": "positive regulation of chlorophyll catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of chlorophyll catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:24719469]"}
{"concept_id": "C3894898", "aliases": [], "types": ["T044"], "canonical_name": "activation of chlorophyll breakdown"}
{"concept_id": "C3894899", "aliases": ["activation of chlorophyll degradation", "activation of chlorophyll catabolism"], "types": ["T044"], "canonical_name": "activation of chlorophyll catabolic process"}
{"concept_id": "C3894900", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic transport", "definition": "Any process that modulates the frequency, rate or extent of cytoplasmic transport. [GO_REF:0000058, GOC:TermGenie, PMID:25049409]"}
{"concept_id": "C3894901", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic streaming"}
{"concept_id": "C3894902", "aliases": ["downregulation of cytoplasmic transport", "down regulation of cytoplasmic transport", "down-regulation of cytoplasmic transport"], "types": ["T043"], "canonical_name": "negative regulation of cytoplasmic transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. [GO_REF:0000058, GOC:TermGenie, PMID:25049409]"}
{"concept_id": "C3894903", "aliases": ["down-regulation of cytoplasmic streaming"], "types": ["T043"], "canonical_name": "down regulation of cytoplasmic streaming"}
{"concept_id": "C3894904", "aliases": ["negative regulation of cytoplasmic streaming"], "types": ["T043"], "canonical_name": "downregulation of cytoplasmic streaming"}
{"concept_id": "C3894905", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytoplasmic streaming"}
{"concept_id": "C3894906", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytoplasmic transport"}
{"concept_id": "C3894907", "aliases": ["upregulation of cytoplasmic transport", "up regulation of cytoplasmic transport", "up-regulation of cytoplasmic transport"], "types": ["T043"], "canonical_name": "positive regulation of cytoplasmic transport", "definition": "Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. [GO_REF:0000058, GOC:TermGenie, PMID:25049409]"}
{"concept_id": "C3894908", "aliases": [], "types": ["T043"], "canonical_name": "activation of cytoplasmic streaming"}
{"concept_id": "C3894909", "aliases": [], "types": ["T043"], "canonical_name": "activation of cytoplasmic transport"}
{"concept_id": "C3894910", "aliases": ["up regulation of cytoplasmic streaming", "up-regulation of cytoplasmic streaming", "upregulation of cytoplasmic streaming"], "types": ["T043"], "canonical_name": "positive regulation of cytoplasmic streaming"}
{"concept_id": "C3894911", "aliases": ["regulation by virus of host cytoplasmic streaming", "viral modulation of host cytoplasmic trafficking", "regulation by virus of host cytoplasmic transport"], "types": ["T043"], "canonical_name": "modulation by virus of host cytoplasmic transport", "definition": "Modulation by an infecting virus of host cytoplasmic transport. [GO_REF:0000063, GOC:TermGenie, PMID:25049409]"}
{"concept_id": "C3894912", "aliases": ["modulation by symbiont of host cell movement", "modulation by symbiont of host cell locomotion", "regulation by symbiont of host cell motility"], "types": ["T040"], "canonical_name": "modulation by symbiont of host cell motility", "definition": "Modulation of host cell motility by a symbiont of that host. [GO_REF:0000063, GOC:TermGenie, PMID:25049409]"}
{"concept_id": "C3894913", "aliases": [], "types": ["T045"], "canonical_name": "phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter", "definition": "Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter. [GO_REF:0000060, GOC:TermGenie, PMID:19328067]"}
{"concept_id": "C3894914", "aliases": [], "types": ["T045"], "canonical_name": "phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter", "definition": "Any phosphorylation of RNA polymerase II C-terminal domain serine 2 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter. [GO_REF:0000060, GOC:TermGenie, PMID:19328067]"}
{"concept_id": "C3894915", "aliases": ["regulation of type IV fimbria biogenesis", "regulation of type 4 pilus biogenesis", "regulation of type IV fimbrium biogenesis", "regulation of type IV fimbriae biogenesis", "regulation of type IV fimbrium assembly", "regulation of type IV fimbria assembly", "regulation of type IV fimbrial assembly", "regulation of TFP biogenesis", "regulation of type IV fimbrial biogenesis", "regulation of type IV fimbriae assembly", "regulation of type IV pilus biosynthesis"], "types": ["T043"], "canonical_name": "regulation of type IV pilus biogenesis", "definition": "Any process that modulates the frequency, rate or extent of type IV pilus biogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:25049409]"}
{"concept_id": "C3894916", "aliases": ["down regulation of type IV fimbriae assembly", "down regulation of TFP biogenesis", "downregulation of type IV fimbrium biogenesis", "negative regulation of type IV fimbriae assembly", "down-regulation of type IV fimbrium biogenesis", "down regulation of type IV fimbria biogenesis", "downregulation of type IV fimbriae biogenesis", "down regulation of type IV pilus biogenesis", "downregulation of type IV pilus biosynthesis", "down-regulation of type IV fimbriae biogenesis", "negative regulation of type IV fimbria biogenesis", "down regulation of type IV fimbrial biogenesis", "negative regulation of type IV fimbrial biogenesis", "down regulation of type 4 pilus biogenesis", "negative regulation of type IV fimbrium biogenesis", "downregulation of type IV fimbrial biogenesis", "downregulation of type IV fimbria biogenesis", "down-regulation of type IV fimbrial assembly", "down regulation of type IV fimbrium assembly", "down regulation of type IV fimbria assembly", "downregulation of TFP biogenesis", "negative regulation of type IV fimbrial assembly", "downregulation of type IV fimbria assembly", "down-regulation of type IV fimbrium assembly", "negative regulation of type 4 pilus biogenesis", "downregulation of type IV pilus biogenesis", "down-regulation of type 4 pilus biogenesis", "down-regulation of type IV pilus biogenesis", "downregulation of type IV fimbrium assembly", "down-regulation of type IV fimbria biogenesis", "negative regulation of type IV fimbria assembly", "down-regulation of type IV pilus biosynthesis", "downregulation of type IV fimbrial assembly", "down regulation of type IV pilus biosynthesis", "down regulation of type IV fimbrium biogenesis", "down regulation of type IV fimbriae biogenesis", "down-regulation of TFP biogenesis", "down-regulation of type IV fimbriae assembly", "negative regulation of TFP biogenesis", "negative regulation of type IV fimbrium assembly", "down-regulation of type IV fimbria assembly", "down regulation of type IV fimbrial assembly", "downregulation of type IV fimbriae assembly", "downregulation of type 4 pilus biogenesis", "down-regulation of type IV fimbrial biogenesis", "negative regulation of type IV fimbriae biogenesis", "negative regulation of type IV pilus biosynthesis"], "types": ["T043"], "canonical_name": "negative regulation of type IV pilus biogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of type IV pilus biogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:25049409]"}
{"concept_id": "C3894917", "aliases": ["inhibition of type IV pilus biosynthesis", "inhibition of type IV fimbrium biogenesis", "inhibition of type IV fimbrial biogenesis", "inhibition of type IV pilus biogenesis", "inhibition of type IV fimbrium assembly", "inhibition of type IV fimbrial assembly", "inhibition of type 4 pilus biogenesis"], "types": ["T043"], "canonical_name": "inhibition of TFP biogenesis"}
{"concept_id": "C3894918", "aliases": ["inhibition of type IV fimbriae assembly"], "types": ["T043"], "canonical_name": "inhibition of type IV fimbria assembly"}
{"concept_id": "C3894919", "aliases": ["inhibition of type IV fimbriae biogenesis"], "types": ["T043"], "canonical_name": "inhibition of type IV fimbria biogenesis"}
{"concept_id": "C3894920", "aliases": ["upregulation of type IV pilus biogenesis", "up-regulation of type IV fimbriae biogenesis", "up regulation of type IV fimbrium assembly", "positive regulation of type IV fimbriae assembly", "up regulation of type IV fimbriae assembly", "up regulation of type 4 pilus biogenesis", "positive regulation of type IV fimbria biogenesis", "up-regulation of type IV fimbrium biogenesis", "positive regulation of type IV pilus biosynthesis", "up regulation of type IV fimbriae biogenesis", "up regulation of type IV pilus biogenesis", "upregulation of type IV fimbriae biogenesis", "up-regulation of type 4 pilus biogenesis", "upregulation of type IV fimbrium biogenesis", "up-regulation of type IV fimbriae assembly", "up regulation of type IV fimbrial assembly", "up-regulation of type IV fimbrial assembly", "upregulation of type IV fimbriae assembly", "positive regulation of type IV fimbrium biogenesis", "upregulation of type IV pilus biosynthesis", "up-regulation of type IV pilus biogenesis", "upregulation of TFP biogenesis", "up-regulation of type IV fimbrial biogenesis", "positive regulation of type IV fimbria assembly", "upregulation of type IV fimbrial assembly", "positive regulation of type 4 pilus biogenesis", "up-regulation of type IV pilus biosynthesis", "up-regulation of type IV fimbria assembly", "up-regulation of type IV fimbrium assembly", "positive regulation of type IV fimbrial assembly", "up regulation of type IV fimbria assembly", "up regulation of type IV fimbrial biogenesis", "up regulation of type IV pilus biosynthesis", "upregulation of type IV fimbrial biogenesis", "up regulation of type IV fimbrium biogenesis", "up regulation of type IV fimbria biogenesis", "upregulation of type 4 pilus biogenesis", "upregulation of type IV fimbria biogenesis", "positive regulation of type IV fimbrial biogenesis", "upregulation of type IV fimbria assembly", "up regulation of TFP biogenesis", "up-regulation of TFP biogenesis", "up-regulation of type IV fimbria biogenesis", "upregulation of type IV fimbrium assembly", "positive regulation of type IV fimbrium assembly", "positive regulation of TFP biogenesis", "positive regulation of type IV fimbriae biogenesis"], "types": ["T043"], "canonical_name": "positive regulation of type IV pilus biogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of type IV pilus biogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:25049409]"}
{"concept_id": "C3894921", "aliases": ["activation of type IV fimbrial assembly", "activation of type IV pilus biogenesis", "activation of type IV fimbrium assembly", "activation of type IV fimbrial biogenesis", "activation of type IV fimbrium biogenesis", "activation of type IV pilus biosynthesis", "activation of type 4 pilus biogenesis"], "types": ["T043"], "canonical_name": "activation of TFP biogenesis"}
{"concept_id": "C3894922", "aliases": ["activation of type IV fimbriae assembly"], "types": ["T043"], "canonical_name": "activation of type IV fimbria assembly"}
{"concept_id": "C3894923", "aliases": ["activation of type IV fimbriae biogenesis"], "types": ["T043"], "canonical_name": "activation of type IV fimbria biogenesis"}
{"concept_id": "C3894924", "aliases": [], "types": ["T043"], "canonical_name": "regulation of complement-dependent cytotoxicity", "definition": "Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity. [GO_REF:0000058, GOC:TermGenie, PMID:24280217]"}
{"concept_id": "C3894925", "aliases": ["down-regulation of complement-dependent cytotoxicity", "down regulation of complement-dependent cytotoxicity", "downregulation of complement-dependent cytotoxicity"], "types": ["T043"], "canonical_name": "negative regulation of complement-dependent cytotoxicity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity. [GO_REF:0000058, GOC:TermGenie, PMID:24280217]"}
{"concept_id": "C3894926", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of complement-dependent cytotoxicity"}
{"concept_id": "C3894927", "aliases": ["up-regulation of complement-dependent cytotoxicity", "up regulation of complement-dependent cytotoxicity", "upregulation of complement-dependent cytotoxicity"], "types": ["T043"], "canonical_name": "positive regulation of complement-dependent cytotoxicity", "definition": "Any process that activates or increases the frequency, rate or extent of complement-dependent cytotoxicity. [GO_REF:0000058, GOC:TermGenie, PMID:24280217]"}
{"concept_id": "C3894928", "aliases": [], "types": ["T043"], "canonical_name": "activation of complement-dependent cytotoxicity"}
{"concept_id": "C3894929", "aliases": ["L-altrarate(1-) metabolism"], "types": ["T044"], "canonical_name": "L-altrarate metabolic process", "definition": "The chemical reactions and pathways involving L-altrarate. [GO_REF:0000068, GOC:TermGenie, PMID:17649980]"}
{"concept_id": "C3894930", "aliases": ["L-altrarate(1-) catabolism", "L-altrarate(1-) breakdown", "L-altrarate(1-) degradation"], "types": ["T044"], "canonical_name": "L-altrarate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of L-altrarate. [GO_REF:0000068, GOC:TermGenie, PMID:17649980]"}
{"concept_id": "C3894931", "aliases": [], "types": ["T038"], "canonical_name": "regulation of asexual reproduction", "definition": "Any process that modulates the frequency, rate or extent of asexual reproduction. [GO_REF:0000058, GOC:TermGenie, PMID:24390142]"}
{"concept_id": "C3894932", "aliases": ["downregulation of asexual reproduction", "down regulation of asexual reproduction", "down-regulation of asexual reproduction"], "types": ["T039"], "canonical_name": "negative regulation of asexual reproduction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction. [GO_REF:0000058, GOC:TermGenie, PMID:24390142]"}
{"concept_id": "C3894933", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of asexual reproduction"}
{"concept_id": "C3894934", "aliases": ["up-regulation of asexual reproduction", "upregulation of asexual reproduction", "up regulation of asexual reproduction"], "types": ["T039"], "canonical_name": "positive regulation of asexual reproduction", "definition": "Any process that activates or increases the frequency, rate or extent of asexual reproduction. [GO_REF:0000058, GOC:TermGenie, PMID:24390142]"}
{"concept_id": "C3894935", "aliases": ["regulation of chemorepellant activity"], "types": ["T043"], "canonical_name": "regulation of chemorepellent activity", "definition": "Any process that modulates the frequency, rate or extent of chemorepellent activity. [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142]"}
{"concept_id": "C3894936", "aliases": ["down regulation of chemorepellant activity", "downregulation of chemorepellant activity", "downregulation of chemorepellent activity", "down regulation of chemorepellent activity", "negative regulation of chemorepellant activity", "down-regulation of chemorepellent activity", "down-regulation of chemorepellant activity"], "types": ["T044"], "canonical_name": "negative regulation of chemorepellent activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chemorepellent activity. [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142]"}
{"concept_id": "C3894937", "aliases": ["inhibition of chemorepellent activity"], "types": ["T044"], "canonical_name": "inhibition of chemorepellant activity"}
{"concept_id": "C3894938", "aliases": ["upregulation of chemorepellent activity", "upregulation of chemorepellant activity", "positive regulation of chemorepellant activity", "up regulation of chemorepellant activity", "up-regulation of chemorepellent activity", "up regulation of chemorepellent activity", "up-regulation of chemorepellant activity"], "types": ["T044"], "canonical_name": "positive regulation of chemorepellent activity", "definition": "Any process that activates or increases the frequency, rate or extent of chemorepellent activity. [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142]"}
{"concept_id": "C3894939", "aliases": ["activation of chemorepellent activity"], "types": ["T044"], "canonical_name": "activation of chemorepellant activity"}
{"concept_id": "C3894940", "aliases": [], "types": ["T040"], "canonical_name": "regulation of sprouting angiogenesis", "definition": "Any process that modulates the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958]"}
{"concept_id": "C3894941", "aliases": ["down regulation of sprouting angiogenesis", "down-regulation of sprouting angiogenesis", "downregulation of sprouting angiogenesis"], "types": ["T043"], "canonical_name": "negative regulation of sprouting angiogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958]"}
{"concept_id": "C3894942", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sprouting angiogenesis"}
{"concept_id": "C3894943", "aliases": ["up-regulation of sprouting angiogenesis", "up regulation of sprouting angiogenesis", "upregulation of sprouting angiogenesis"], "types": ["T040"], "canonical_name": "positive regulation of sprouting angiogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958]"}
{"concept_id": "C3894944", "aliases": [], "types": ["T040"], "canonical_name": "activation of sprouting angiogenesis"}
{"concept_id": "C3894945", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cleavage furrow formation", "definition": "Any cleavage furrow formation that is involved in mitotic cell cycle. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]"}
{"concept_id": "C3894946", "aliases": [], "types": ["T043"], "canonical_name": "cleavage furrow positioning involved in mitotic cell cycle"}
{"concept_id": "C3894947", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cap-dependent translational initiation", "definition": "Any process that modulates the frequency, rate or extent of cap-dependent translational initiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894948", "aliases": ["down regulation of cap-dependent translational initiation", "down-regulation of cap-dependent translational initiation", "downregulation of cap-dependent translational initiation"], "types": ["T043"], "canonical_name": "negative regulation of cap-dependent translational initiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cap-dependent translational initiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894949", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cap-dependent translational initiation"}
{"concept_id": "C3894950", "aliases": ["upregulation of cap-dependent translational initiation", "up-regulation of cap-dependent translational initiation", "up regulation of cap-dependent translational initiation"], "types": ["T045"], "canonical_name": "positive regulation of cap-dependent translational initiation", "definition": "Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995]"}
{"concept_id": "C3894951", "aliases": [], "types": ["T045"], "canonical_name": "activation of cap-dependent translational initiation"}
{"concept_id": "C3894952", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cap-independent translational initiation", "definition": "Any process that modulates the frequency, rate or extent of cap-independent translational initiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894953", "aliases": ["downregulation of cap-independent translational initiation", "down-regulation of cap-independent translational initiation", "down regulation of cap-independent translational initiation"], "types": ["T043"], "canonical_name": "negative regulation of cap-independent translational initiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3894954", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cap-independent translational initiation"}
{"concept_id": "C3894955", "aliases": ["upregulation of cap-independent translational initiation", "up regulation of cap-independent translational initiation", "up-regulation of cap-independent translational initiation"], "types": ["T045"], "canonical_name": "positive regulation of cap-independent translational initiation", "definition": "Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995]"}
{"concept_id": "C3894956", "aliases": [], "types": ["T045"], "canonical_name": "activation of cap-independent translational initiation"}
{"concept_id": "C3894957", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial cell-cell adhesion involved in epithelium migration", "definition": "Any process that modulates the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]"}
{"concept_id": "C3894958", "aliases": ["down-regulation of epithelial cell-cell adhesion involved in epithelium migration", "downregulation of epithelial cell-cell adhesion involved in epithelium migration", "down regulation of epithelial cell-cell adhesion involved in epithelium migration"], "types": ["T043"], "canonical_name": "negative regulation of epithelial cell-cell adhesion involved in epithelium migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]"}
{"concept_id": "C3894959", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of epithelial cell-cell adhesion involved in epithelium migration"}
{"concept_id": "C3894960", "aliases": ["up regulation of epithelial cell-cell adhesion involved in epithelium migration", "upregulation of epithelial cell-cell adhesion involved in epithelium migration", "up-regulation of epithelial cell-cell adhesion involved in epithelium migration"], "types": ["T043"], "canonical_name": "positive regulation of epithelial cell-cell adhesion involved in epithelium migration", "definition": "Any process that activates or increases the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]"}
{"concept_id": "C3894961", "aliases": [], "types": ["T043"], "canonical_name": "activation of epithelial cell-cell adhesion involved in epithelium migration"}
{"concept_id": "C3894962", "aliases": [], "types": ["T043"], "canonical_name": "regulation of border follicle cell migration", "definition": "Any process that modulates the frequency, rate or extent of border follicle cell migration. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]"}
{"concept_id": "C3894963", "aliases": [], "types": ["T043"], "canonical_name": "regulation of border cell migration"}
{"concept_id": "C3894964", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of border follicle cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of border follicle cell migration. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]"}
{"concept_id": "C3894965", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of border follicle cell migration"}
{"concept_id": "C3894966", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of border follicle cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of border follicle cell migration. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]"}
{"concept_id": "C3894967", "aliases": [], "types": ["T043"], "canonical_name": "activation of border follicle cell migration"}
{"concept_id": "C3894968", "aliases": [], "types": ["T038"], "canonical_name": "regulation of wound healing, spreading of epidermal cells", "definition": "Any process that modulates the frequency, rate or extent of wound healing, spreading of epidermal cells. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]"}
{"concept_id": "C3894969", "aliases": ["downregulation of wound healing, spreading of epidermal cells", "down-regulation of wound healing, spreading of epidermal cells", "down regulation of wound healing, spreading of epidermal cells"], "types": ["T043"], "canonical_name": "negative regulation of wound healing, spreading of epidermal cells", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]"}
{"concept_id": "C3894970", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of wound healing, spreading of epidermal cells"}
{"concept_id": "C3894971", "aliases": ["up regulation of wound healing, spreading of epidermal cells", "up-regulation of wound healing, spreading of epidermal cells", "upregulation of wound healing, spreading of epidermal cells"], "types": ["T043"], "canonical_name": "positive regulation of wound healing, spreading of epidermal cells", "definition": "Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]"}
{"concept_id": "C3894972", "aliases": [], "types": ["T043"], "canonical_name": "activation of wound healing, spreading of epidermal cells"}
{"concept_id": "C3894973", "aliases": ["methionine import into cell"], "types": ["T043"], "canonical_name": "methionine import across plasma membrane", "definition": "The directed movement of methionine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:17556368]"}
{"concept_id": "C3894984", "aliases": ["protein localization in horsetail-astral microtubule array", "protein localisation in horsetail-astral microtubule array", "protein localisation to horsetail-astral microtubule array"], "types": ["T043"], "canonical_name": "protein localization to horsetail-astral microtubule array", "definition": "A process in which a protein is transported to, or maintained in, a location within a horsetail-astral microtubule array. [GO_REF:0000087, GOC:TermGenie, PMID:11907273]"}
{"concept_id": "C3894985", "aliases": ["down regulation of microvillus assembly", "down-regulation of microvillus assembly", "downregulation of microvillus assembly"], "types": ["T043"], "canonical_name": "negative regulation of microvillus assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]"}
{"concept_id": "C3894986", "aliases": ["downregulation of microvillus biogenesis", "negative regulation of microvillus biogenesis", "down-regulation of microvillus biogenesis"], "types": ["T043"], "canonical_name": "down regulation of microvillus biogenesis"}
{"concept_id": "C3894987", "aliases": ["inhibition of microvillus biogenesis"], "types": ["T043"], "canonical_name": "inhibition of microvillus assembly"}
{"concept_id": "C3894988", "aliases": ["up regulation of microvillus assembly", "upregulation of microvillus assembly", "up-regulation of microvillus biogenesis", "upregulation of microvillus biogenesis", "up-regulation of microvillus assembly", "up regulation of microvillus biogenesis", "positive regulation of microvillus biogenesis"], "types": ["T043"], "canonical_name": "positive regulation of microvillus assembly", "definition": "Any process that activates or increases the frequency, rate or extent of microvillus assembly. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]"}
{"concept_id": "C3894989", "aliases": ["activation of microvillus biogenesis"], "types": ["T043"], "canonical_name": "activation of microvillus assembly"}
{"concept_id": "C3894990", "aliases": ["gland of Meibom development", "glandula tarsales development", "Meibomian gland development"], "types": ["T042"], "canonical_name": "tarsal gland development", "definition": "The process whose specific outcome is the progression of a tarsal gland over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, PMID:20664693]"}
{"concept_id": "C3894991", "aliases": [], "types": ["T042"], "canonical_name": "tarsoconjunctival gland development"}
{"concept_id": "C3894992", "aliases": ["intestinum crassum caecum development", "cecum development", "ceca development", "intestinum crassum cecum development", "caeca development"], "types": ["T042"], "canonical_name": "caecum development", "definition": "The process whose specific outcome is the progression of a caecum over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8]"}
{"concept_id": "C3894993", "aliases": ["blindgut development"], "types": ["T042"], "canonical_name": "blind intestine development"}
{"concept_id": "C3894994", "aliases": [], "types": ["T042"], "canonical_name": "intestinum caecum development"}
{"concept_id": "C3894995", "aliases": ["stroma of cornea development", "corneal stroma development"], "types": ["T042"], "canonical_name": "substantia propria of cornea development", "definition": "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, PMID:12556382]"}
{"concept_id": "C3894996", "aliases": [], "types": ["T042"], "canonical_name": "substantia propria development"}
{"concept_id": "C3894997", "aliases": ["gullet development", "esophageal development", "oesophagus development"], "types": ["T038"], "canonical_name": "esophagus development", "definition": "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8]"}
{"concept_id": "C3894998", "aliases": [], "types": ["T043"], "canonical_name": "enterocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of an enterocyte. [GO_REF:0000086, GOC:TermGenie, PMID:16782882, Wikipedia:List_of_intestinal_epithelial_differentiation_genes]"}
{"concept_id": "C3894999", "aliases": ["down regulation of RNA interference, production of guide RNAs", "down-regulation of production of siRNA involved in RNA interference", "negative regulation of production of siRNA involved in RNA interference", "downregulation of RNA interference, production of siRNA", "negative regulation of production of siRNA involved in PTGS", "negative regulation of production of guide RNAs involved in RNA interference", "down-regulation of RNA interference, production of guide RNAs", "downregulation of production of siRNA involved in RNA interference", "down-regulation of production of guide RNAs involved in RNA interference", "down regulation of production of siRNA involved in RNA interference", "negative regulation of RNA interference, production of siRNA", "down-regulation of RNA interference, production of siRNA", "down regulation of RNA interference, production of siRNA", "negative regulation of RNA interference, production of guide RNAs", "down regulation of production of guide RNAs involved in RNA interference", "downregulation of production of guide RNAs involved in RNA interference", "downregulation of RNA interference, production of guide RNAs"], "types": ["T045"], "canonical_name": "negative regulation of siRNA production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of production of siRNA involved in RNA interference. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182]"}
{"concept_id": "C3895000", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of production of guide RNAs involved in RNA interference"}
{"concept_id": "C3895001", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of production of siRNA involved in RNA interference"}
{"concept_id": "C3895002", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of RNA interference, production of guide RNAs"}
{"concept_id": "C3895003", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of RNA interference, production of siRNA"}
{"concept_id": "C3895004", "aliases": ["up regulation of production of siRNA involved in RNA interference", "up-regulation of production of guide RNAs involved in RNA interference", "upregulation of production of guide RNAs involved in RNA interference", "up regulation of RNA interference, production of guide RNAs", "up-regulation of RNA interference, production of siRNA", "positive regulation of RNA interference, production of guide RNAs", "upregulation of RNA interference, production of guide RNAs", "up regulation of RNA interference, production of siRNA", "upregulation of RNA interference, production of siRNA", "positive regulation of production of siRNA involved in RNA interference", "up-regulation of RNA interference, production of guide RNAs", "upregulation of production of siRNA involved in RNA interference", "positive regulation of RNA interference, production of siRNA", "up regulation of production of guide RNAs involved in RNA interference", "positive regulation of production of siRNA involved in PTGS", "up-regulation of production of siRNA involved in RNA interference", "positive regulation of production of guide RNAs involved in RNA interference"], "types": ["T045"], "canonical_name": "positive regulation of siRNA production", "definition": "Any process that activates or increases the frequency, rate or extent of production of siRNA involved in RNA interference. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182]"}
{"concept_id": "C3895005", "aliases": [], "types": ["T045"], "canonical_name": "activation of production of guide RNAs involved in RNA interference"}
{"concept_id": "C3895006", "aliases": [], "types": ["T045"], "canonical_name": "activation of production of siRNA involved in RNA interference"}
{"concept_id": "C3895007", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA interference, production of guide RNAs"}
{"concept_id": "C3895008", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA interference, production of siRNA"}
{"concept_id": "C3895009", "aliases": ["regulation of blood cell formation", "regulation of hematopoiesis", "regulation of blood cell biosynthesis", "regulation of haemopoiesis"], "types": ["T038"], "canonical_name": "regulation of hemopoiesis", "definition": "Any process that modulates the frequency, rate or extent of hemopoiesis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]"}
{"concept_id": "C3895010", "aliases": ["negative regulation of blood cell formation", "inhibition of hematopoiesis", "down regulation of blood cell formation", "downregulation of hematopoiesis", "negative regulation of haemopoiesis", "down-regulation of blood cell formation", "downregulation of blood cell formation", "down-regulation of hematopoiesis", "down-regulation of hemopoiesis", "negative regulation of blood cell biosynthesis", "down-regulation of blood cell biosynthesis", "down regulation of hematopoiesis", "downregulation of hemopoiesis", "downregulation of blood cell biosynthesis", "down regulation of haemopoiesis", "down-regulation of haemopoiesis", "negative regulation of hematopoiesis", "down regulation of blood cell biosynthesis", "downregulation of haemopoiesis", "down regulation of hemopoiesis"], "types": ["T039"], "canonical_name": "negative regulation of hemopoiesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]"}
{"concept_id": "C3895011", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of blood cell biosynthesis"}
{"concept_id": "C3895012", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of blood cell formation"}
{"concept_id": "C3895013", "aliases": ["inhibition of hemopoiesis"], "types": ["T039"], "canonical_name": "inhibition of haemopoiesis"}
{"concept_id": "C3895014", "aliases": ["up-regulation of hematopoiesis", "upregulation of hemopoiesis", "upregulation of hematopoiesis", "positive regulation of blood cell biosynthesis", "up-regulation of hemopoiesis", "positive regulation of hematopoiesis", "up-regulation of blood cell biosynthesis", "positive regulation of haemopoiesis", "upregulation of blood cell formation", "up-regulation of blood cell formation", "positive regulation of blood cell formation", "upregulation of haemopoiesis", "up regulation of hematopoiesis", "up regulation of haemopoiesis", "up regulation of blood cell biosynthesis", "up regulation of hemopoiesis", "up-regulation of haemopoiesis", "upregulation of blood cell biosynthesis", "up regulation of blood cell formation"], "types": ["T039"], "canonical_name": "positive regulation of hemopoiesis", "definition": "Any process that activates or increases the frequency, rate or extent of hemopoiesis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]"}
{"concept_id": "C3895015", "aliases": ["activation of blood cell formation", "activation of hematopoiesis"], "types": ["T039"], "canonical_name": "activation of blood cell biosynthesis"}
{"concept_id": "C3895016", "aliases": ["activation of hemopoiesis"], "types": ["T039"], "canonical_name": "activation of haemopoiesis"}
{"concept_id": "C3895017", "aliases": ["uterine glands set development", "uterine glands development", "endometrium gland development", "endometrial gland development", "set of uterine glands development"], "types": ["T039"], "canonical_name": "uterine gland development", "definition": "The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, PMID:23619340]"}
{"concept_id": "C3895018", "aliases": [], "types": ["T039"], "canonical_name": "glandulae uterinae development"}
{"concept_id": "C3895019", "aliases": [], "types": ["T039"], "canonical_name": "glandular part of endometrium development"}
{"concept_id": "C3895020", "aliases": [], "types": ["T043"], "canonical_name": "spermine transmembrane transport", "definition": "The process in which spermine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:15637075]"}
{"concept_id": "C3895021", "aliases": [], "types": ["T043"], "canonical_name": "spermidine transmembrane transport", "definition": "The process in which spermidine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:15637075]"}
{"concept_id": "C3895022", "aliases": [], "types": ["T043"], "canonical_name": "cysteine transmembrane transport", "definition": "The directed movement of cysteine across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:17435223]"}
{"concept_id": "C3895023", "aliases": [], "types": ["T043"], "canonical_name": "asparagine transmembrane transport", "definition": "The directed movement of asparagine across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:18503766]"}
{"concept_id": "C3895024", "aliases": [], "types": ["T043"], "canonical_name": "isoleucine transmembrane transport", "definition": "The directed movement of isoleucine across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:18503766]"}
{"concept_id": "C3895025", "aliases": [], "types": ["T043"], "canonical_name": "regulation of aerobic respiration", "definition": "Any process that modulates the frequency, rate or extent of aerobic respiration. [GO_REF:0000058, GOC:TermGenie, PMID:19266076]"}
{"concept_id": "C3895028", "aliases": ["regulation of inhibitor of NF-kappaB phosphorylation", "regulation of inhibitor of kappaB phosphorylation", "regulation of IKB phosphorylation", "regulation of IkappaB phosphorylation"], "types": ["T044"], "canonical_name": "regulation of I-kappaB phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of I-kappaB phosphorylation. [GO_REF:0000058, GOC:TermGenie, PMID:23675531]"}
{"concept_id": "C3895029", "aliases": ["negative regulation of inhibitor of NF-kappaB phosphorylation", "negative regulation of IKB phosphorylation", "down-regulation of IKB phosphorylation", "downregulation of inhibitor of NF-kappaB phosphorylation", "down-regulation of IkappaB phosphorylation", "down regulation of I-kappaB phosphorylation", "down regulation of inhibitor of kappaB phosphorylation", "down regulation of IkappaB phosphorylation", "downregulation of IkappaB phosphorylation", "negative regulation of inhibitor of kappaB phosphorylation", "down-regulation of inhibitor of kappaB phosphorylation", "down regulation of inhibitor of NF-kappaB phosphorylation", "downregulation of IKB phosphorylation", "down-regulation of I-kappaB phosphorylation", "negative regulation of IkappaB phosphorylation", "down-regulation of inhibitor of NF-kappaB phosphorylation", "downregulation of I-kappaB phosphorylation", "down regulation of IKB phosphorylation", "downregulation of inhibitor of kappaB phosphorylation"], "types": ["T044"], "canonical_name": "negative regulation of I-kappaB phosphorylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation. [GO_REF:0000058, GOC:TermGenie, PMID:23675531]"}
{"concept_id": "C3895030", "aliases": ["inhibition of IkappaB phosphorylation", "inhibition of IKB phosphorylation", "inhibition of inhibitor of NF-kappaB phosphorylation", "inhibition of inhibitor of kappaB phosphorylation"], "types": ["T044"], "canonical_name": "inhibition of I-kappaB phosphorylation"}
{"concept_id": "C3895031", "aliases": ["up-regulation of inhibitor of kappaB phosphorylation", "up regulation of IkappaB phosphorylation", "up-regulation of I-kappaB phosphorylation", "upregulation of IkappaB phosphorylation", "up regulation of I-kappaB phosphorylation", "up regulation of inhibitor of kappaB phosphorylation", "upregulation of IKB phosphorylation", "positive regulation of IKB phosphorylation", "positive regulation of IkappaB phosphorylation", "up-regulation of inhibitor of NF-kappaB phosphorylation", "upregulation of I-kappaB phosphorylation", "up regulation of IKB phosphorylation", "positive regulation of inhibitor of NF-kappaB phosphorylation", "upregulation of inhibitor of kappaB phosphorylation", "positive regulation of inhibitor of kappaB phosphorylation", "up regulation of inhibitor of NF-kappaB phosphorylation", "up-regulation of IKB phosphorylation", "up-regulation of IkappaB phosphorylation", "upregulation of inhibitor of NF-kappaB phosphorylation"], "types": ["T044"], "canonical_name": "positive regulation of I-kappaB phosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation. [GO_REF:0000058, GOC:TermGenie, PMID:23675531]"}
{"concept_id": "C3895032", "aliases": ["activation of IKB phosphorylation", "activation of inhibitor of kappaB phosphorylation", "activation of inhibitor of NF-kappaB phosphorylation", "activation of IkappaB phosphorylation"], "types": ["T044"], "canonical_name": "activation of I-kappaB phosphorylation"}
{"concept_id": "C3895033", "aliases": [], "types": ["T043"], "canonical_name": "regulation of centriole elongation", "definition": "Any process that modulates the frequency, rate or extent of centriole elongation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]"}
{"concept_id": "C3895034", "aliases": ["downregulation of centriole elongation", "down-regulation of centriole elongation", "down regulation of centriole elongation"], "types": ["T043"], "canonical_name": "negative regulation of centriole elongation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of centriole elongation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]"}
{"concept_id": "C3895035", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of centriole elongation"}
{"concept_id": "C3895036", "aliases": ["up-regulation of centriole elongation", "upregulation of centriole elongation", "up regulation of centriole elongation"], "types": ["T045"], "canonical_name": "positive regulation of centriole elongation", "definition": "Any process that activates or increases the frequency, rate or extent of centriole elongation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]"}
{"concept_id": "C3895037", "aliases": [], "types": ["T045"], "canonical_name": "activation of centriole elongation"}
{"concept_id": "C3895038", "aliases": ["regulation of phospholipid metabolism"], "types": ["T043"], "canonical_name": "regulation of phospholipid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of phospholipid metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10657240]"}
{"concept_id": "C3895039", "aliases": ["down-regulation of phospholipid metabolism", "negative regulation of phospholipid metabolism", "down-regulation of phospholipid metabolic process", "downregulation of phospholipid metabolism", "down regulation of phospholipid metabolic process", "downregulation of phospholipid metabolic process", "down regulation of phospholipid metabolism"], "types": ["T043"], "canonical_name": "negative regulation of phospholipid metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10657240]"}
{"concept_id": "C3895040", "aliases": ["inhibition of phospholipid metabolism"], "types": ["T043"], "canonical_name": "inhibition of phospholipid metabolic process"}
{"concept_id": "C3895041", "aliases": ["up-regulation of phospholipid metabolism", "upregulation of phospholipid metabolic process", "up regulation of phospholipid metabolism", "positive regulation of phospholipid metabolism", "up-regulation of phospholipid metabolic process", "upregulation of phospholipid metabolism", "up regulation of phospholipid metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of phospholipid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10657240]"}
{"concept_id": "C3895042", "aliases": ["activation of phospholipid metabolism"], "types": ["T043"], "canonical_name": "activation of phospholipid metabolic process"}
{"concept_id": "C3895043", "aliases": ["lutein cell differentiation"], "types": ["T043"], "canonical_name": "luteal cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a luteal cell. Large luteal cells develop from granulosa cells. Small luteal cells develop from theca cells. [GO_REF:0000086, GOC:TermGenie, MP:0001133]"}
{"concept_id": "C3895044", "aliases": ["regulation of plasma membrane organisation"], "types": ["T043"], "canonical_name": "regulation of plasma membrane organization", "definition": "Any process that modulates the frequency, rate or extent of plasma membrane organization. [GO_REF:0000058, GOC:TermGenie, PMID:24514900]"}
{"concept_id": "C3895045", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plasma membrane organization and biogenesis"}
{"concept_id": "C3895046", "aliases": ["regulation of 3-sn-phosphatidate phosphohydrolase activity", "regulation of phosphatic acid phosphatase activity", "regulation of acid phosphatidyl phosphatase activity", "regulation of phosphatic acid phosphohydrolase activity", "regulation of phosphatidate phosphohydrolase activity", "regulation of phosphatidic acid phosphatase activity"], "types": ["T044"], "canonical_name": "regulation of phosphatidate phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:22334681, PMID:24876385, PMID:25359770]"}
{"concept_id": "C3895047", "aliases": ["up regulation of phosphatidate phosphatase activity", "positive regulation of phosphatidate phosphohydrolase activity", "upregulation of phosphatidic acid phosphatase activity", "up-regulation of acid phosphatidyl phosphatase activity", "upregulation of phosphatidate phosphatase activity", "positive regulation of phosphatic acid phosphatase activity", "up-regulation of phosphatidate phosphohydrolase activity", "upregulation of phosphatic acid phosphatase activity", "up regulation of phosphatidic acid phosphatase activity", "upregulation of 3-sn-phosphatidate phosphohydrolase activity", "positive regulation of phosphatidic acid phosphatase activity", "positive regulation of acid phosphatidyl phosphatase activity", "up regulation of 3-sn-phosphatidate phosphohydrolase activity", "upregulation of phosphatidate phosphohydrolase activity", "up-regulation of phosphatidate phosphatase activity", "up regulation of phosphatidate phosphohydrolase activity", "up-regulation of phosphatic acid phosphohydrolase activity", "up-regulation of phosphatidic acid phosphatase activity", "upregulation of phosphatic acid phosphohydrolase activity", "up regulation of phosphatic acid phosphatase activity", "up regulation of phosphatic acid phosphohydrolase activity", "up-regulation of phosphatic acid phosphatase activity", "up regulation of acid phosphatidyl phosphatase activity", "positive regulation of phosphatic acid phosphohydrolase activity", "positive regulation of 3-sn-phosphatidate phosphohydrolase activity", "up-regulation of 3-sn-phosphatidate phosphohydrolase activity", "upregulation of acid phosphatidyl phosphatase activity"], "types": ["T044"], "canonical_name": "positive regulation of phosphatidate phosphatase activity", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidate phosphatase activity. [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:25359770]"}
{"concept_id": "C3895048", "aliases": ["activation of acid phosphatidyl phosphatase activity", "activation of phosphatidate phosphatase activity", "activation of phosphatic acid phosphatase activity", "activation of phosphatidate phosphohydrolase activity", "activation of phosphatidic acid phosphatase activity", "activation of phosphatic acid phosphohydrolase activity"], "types": ["T044"], "canonical_name": "activation of 3-sn-phosphatidate phosphohydrolase activity"}
{"concept_id": "C3895049", "aliases": ["down-regulation of phosphatidate phosphatase activity", "downregulation of 3-sn-phosphatidate phosphohydrolase activity", "downregulation of phosphatic acid phosphatase activity", "downregulation of phosphatidate phosphatase activity", "downregulation of phosphatidate phosphohydrolase activity", "down-regulation of 3-sn-phosphatidate phosphohydrolase activity", "down regulation of phosphatic acid phosphatase activity", "down regulation of phosphatidic acid phosphatase activity", "down regulation of acid phosphatidyl phosphatase activity", "down regulation of 3-sn-phosphatidate phosphohydrolase activity", "down-regulation of acid phosphatidyl phosphatase activity", "negative regulation of phosphatic acid phosphatase activity", "negative regulation of acid phosphatidyl phosphatase activity", "down-regulation of phosphatidate phosphohydrolase activity", "down regulation of phosphatidate phosphatase activity", "downregulation of phosphatic acid phosphohydrolase activity", "downregulation of phosphatidic acid phosphatase activity", "downregulation of acid phosphatidyl phosphatase activity", "down-regulation of phosphatic acid phosphohydrolase activity", "negative regulation of 3-sn-phosphatidate phosphohydrolase activity", "down regulation of phosphatic acid phosphohydrolase activity", "down regulation of phosphatidate phosphohydrolase activity", "down-regulation of phosphatic acid phosphatase activity", "negative regulation of phosphatic acid phosphohydrolase activity", "negative regulation of phosphatidate phosphohydrolase activity", "down-regulation of phosphatidic acid phosphatase activity", "negative regulation of phosphatidic acid phosphatase activity"], "types": ["T044"], "canonical_name": "negative regulation of phosphatidate phosphatase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidate phosphatase activity. [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:22334681]"}
{"concept_id": "C3895050", "aliases": ["inhibition of phosphatidate phosphohydrolase activity", "inhibition of phosphatidate phosphatase activity", "inhibition of acid phosphatidyl phosphatase activity", "inhibition of phosphatic acid phosphohydrolase activity", "inhibition of phosphatidic acid phosphatase activity", "inhibition of phosphatic acid phosphatase activity"], "types": ["T044"], "canonical_name": "inhibition of 3-sn-phosphatidate phosphohydrolase activity"}
{"concept_id": "C3895051", "aliases": [], "types": ["T042"], "canonical_name": "regulation of anterograde synaptic vesicle transport", "definition": "Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]"}
{"concept_id": "C3895052", "aliases": ["down-regulation of anterograde synaptic vesicle transport", "downregulation of anterograde synaptic vesicle transport", "down regulation of anterograde synaptic vesicle transport"], "types": ["T043"], "canonical_name": "negative regulation of anterograde synaptic vesicle transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde synaptic vesicle transport. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]"}
{"concept_id": "C3895053", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of anterograde synaptic vesicle transport"}
{"concept_id": "C3895054", "aliases": ["upregulation of anterograde synaptic vesicle transport", "up regulation of anterograde synaptic vesicle transport", "up-regulation of anterograde synaptic vesicle transport"], "types": ["T043"], "canonical_name": "positive regulation of anterograde synaptic vesicle transport", "definition": "Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]"}
{"concept_id": "C3895055", "aliases": [], "types": ["T043"], "canonical_name": "activation of anterograde synaptic vesicle transport"}
{"concept_id": "C3895056", "aliases": ["downregulation of pharyngeal pumping", "down regulation of pharyngeal pumping", "down-regulation of pharyngeal pumping"], "types": ["T039"], "canonical_name": "negative regulation of pharyngeal pumping", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pharyngeal pumping. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]"}
{"concept_id": "C3895057", "aliases": ["downregulation of pumping behavior", "down-regulation of pumping behavior"], "types": ["T039"], "canonical_name": "down regulation of pumping behavior"}
{"concept_id": "C3895058", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of pharyngeal pumping"}
{"concept_id": "C3895059", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of pumping behavior"}
{"concept_id": "C3895060", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of pumping behavior"}
{"concept_id": "C3895061", "aliases": ["up regulation of pharyngeal pumping", "upregulation of pharyngeal pumping", "up-regulation of pharyngeal pumping"], "types": ["T039"], "canonical_name": "positive regulation of pharyngeal pumping", "definition": "Any process that activates or increases the frequency, rate or extent of pharyngeal pumping. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]"}
{"concept_id": "C3895062", "aliases": [], "types": ["T039"], "canonical_name": "activation of pharyngeal pumping"}
{"concept_id": "C3895063", "aliases": [], "types": ["T039"], "canonical_name": "activation of pumping behavior"}
{"concept_id": "C3895064", "aliases": ["upregulation of pumping behavior", "up-regulation of pumping behavior", "up regulation of pumping behavior"], "types": ["T039"], "canonical_name": "positive regulation of pumping behavior"}
{"concept_id": "C3895065", "aliases": ["regulation of establishment of protein localization in mitochondrion", "regulation of establishment of protein localisation to mitochondrion"], "types": ["T039"], "canonical_name": "regulation of establishment of protein localization to mitochondrion", "definition": "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion. [GO_REF:0000058, GOC:TermGenie, PMID:16857185]"}
{"concept_id": "C3895066", "aliases": ["downregulation of establishment of protein localisation to mitochondrion", "down regulation of establishment of protein localisation to mitochondrion", "down-regulation of establishment of protein localisation to mitochondrion", "downregulation of establishment of protein localization to mitochondrion", "down regulation of establishment of protein localization in mitochondrion", "down-regulation of establishment of protein localization to mitochondrion", "negative regulation of establishment of protein localisation to mitochondrion", "downregulation of establishment of protein localization in mitochondrion", "down-regulation of establishment of protein localization in mitochondrion", "negative regulation of establishment of protein localization in mitochondrion", "down regulation of establishment of protein localization to mitochondrion"], "types": ["T039"], "canonical_name": "negative regulation of establishment of protein localization to mitochondrion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion. [GO_REF:0000058, GOC:TermGenie, PMID:16857185]"}
{"concept_id": "C3895067", "aliases": ["inhibition of establishment of protein localization to mitochondrion", "inhibition of establishment of protein localization in mitochondrion"], "types": ["T044"], "canonical_name": "inhibition of establishment of protein localisation to mitochondrion"}
{"concept_id": "C3895068", "aliases": ["positive regulation of establishment of protein localisation to mitochondrion", "upregulation of establishment of protein localization to mitochondrion", "up-regulation of establishment of protein localization in mitochondrion", "up-regulation of establishment of protein localization to mitochondrion", "upregulation of establishment of protein localization in mitochondrion", "up regulation of establishment of protein localisation to mitochondrion", "up regulation of establishment of protein localization to mitochondrion", "positive regulation of establishment of protein localization in mitochondrion", "upregulation of establishment of protein localisation to mitochondrion", "up regulation of establishment of protein localization in mitochondrion", "up-regulation of establishment of protein localisation to mitochondrion"], "types": ["T039"], "canonical_name": "positive regulation of establishment of protein localization to mitochondrion", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion. [GO_REF:0000058, GOC:TermGenie, PMID:16857185]"}
{"concept_id": "C3895069", "aliases": ["activation of establishment of protein localization in mitochondrion", "activation of establishment of protein localization to mitochondrion"], "types": ["T039"], "canonical_name": "activation of establishment of protein localisation to mitochondrion"}
{"concept_id": "C3895070", "aliases": ["regulation of H2O2-induced intrinsic apoptotic signaling pathway", "regulation of intrinsic apoptotic signaling pathway in response to H2O2", "regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "definition": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. [GO_REF:0000058, GOC:TermGenie, PMID:18681888]"}
{"concept_id": "C3895071", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hydrogen peroxide-induced apoptosis"}
{"concept_id": "C3895072", "aliases": ["downregulation of H2O2-induced intrinsic apoptotic signaling pathway", "down regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "negative regulation of intrinsic apoptotic signaling pathway in response to H2O2", "down regulation of intrinsic apoptotic signaling pathway in response to H2O2", "down-regulation of intrinsic apoptotic signaling pathway in response to H2O2", "down-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "down regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway", "downregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway", "negative regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway", "downregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "downregulation of intrinsic apoptotic signaling pathway in response to H2O2", "down-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. [GO_REF:0000058, GOC:TermGenie, PMID:18681888]"}
{"concept_id": "C3895073", "aliases": ["down-regulation of H2O2-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "down regulation of H2O2-induced intrinsic apoptotic signaling pathway"}
{"concept_id": "C3895074", "aliases": ["inhibition of hydrogen peroxide-induced intrinsic apoptotic signaling pathway", "inhibition of intrinsic apoptotic signaling pathway in response to H2O2", "inhibition of intrinsic apoptotic signaling pathway in response to hydrogen peroxide"], "types": ["T043"], "canonical_name": "inhibition of H2O2-induced intrinsic apoptotic signaling pathway"}
{"concept_id": "C3895075", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of H2O2-induced intrinsic apoptotic signaling pathway"}
{"concept_id": "C3895076", "aliases": ["up regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway", "up-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway", "up-regulation of intrinsic apoptotic signaling pathway in response to H2O2", "upregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "positive regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway", "up-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "up regulation of intrinsic apoptotic signaling pathway in response to H2O2", "positive regulation of intrinsic apoptotic signaling pathway in response to H2O2", "upregulation of intrinsic apoptotic signaling pathway in response to H2O2", "up regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "upregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "definition": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. [GO_REF:0000058, GOC:TermGenie, PMID:18681888]"}
{"concept_id": "C3895077", "aliases": ["activation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "activation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway", "activation of intrinsic apoptotic signaling pathway in response to H2O2"], "types": ["T043"], "canonical_name": "activation of H2O2-induced intrinsic apoptotic signaling pathway"}
{"concept_id": "C3895078", "aliases": ["upregulation of H2O2-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of H2O2-induced intrinsic apoptotic signaling pathway"}
{"concept_id": "C3895079", "aliases": ["up-regulation of H2O2-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "up regulation of H2O2-induced intrinsic apoptotic signaling pathway"}
{"concept_id": "C3895080", "aliases": ["down regulation of p38 MAPK cascade", "downregulation of p38 cascade", "down-regulation of p38MAPK cascade", "down regulation of p38MAPK cascade", "downregulation of p38 MAPK cascade", "down-regulation of p38 MAPK cascade", "down regulation of p38 cascade", "negative regulation of p38 cascade", "downregulation of p38MAPK cascade", "negative regulation of p38 MAPK cascade", "down-regulation of p38 cascade"], "types": ["T040"], "canonical_name": "negative regulation of p38MAPK cascade", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade. [GO_REF:0000058, GOC:TermGenie, PMID:18681888]"}
{"concept_id": "C3895081", "aliases": ["inhibition of p38 cascade", "inhibition of p38MAPK cascade"], "types": ["T040"], "canonical_name": "inhibition of p38 MAPK cascade"}
{"concept_id": "C3895082", "aliases": ["cortical microtubule plus end"], "types": ["T026"], "canonical_name": "cortical microtubule plus-end", "definition": "The plus-end of a cortical microtubule. [GO_REF:0000064, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3895083", "aliases": ["up regulation of SUMO transferase activity", "up-regulation of SUMO transferase activity", "upregulation of SUMO transferase activity"], "types": ["T044"], "canonical_name": "positive regulation of SUMO transferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of SUMO transferase activity. [GO_REF:0000059, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:19955185]"}
{"concept_id": "C3895084", "aliases": [], "types": ["T044"], "canonical_name": "activation of SMT3 conjugating enzyme"}
{"concept_id": "C3895085", "aliases": [], "types": ["T044"], "canonical_name": "activation of SUMO conjugating enzyme activity"}
{"concept_id": "C3895086", "aliases": [], "types": ["T044"], "canonical_name": "activation of SUMO transferase activity"}
{"concept_id": "C3895087", "aliases": ["up regulation of SMT3 conjugating enzyme", "up-regulation of SMT3 conjugating enzyme", "upregulation of SMT3 conjugating enzyme"], "types": ["T044"], "canonical_name": "positive regulation of SMT3 conjugating enzyme"}
{"concept_id": "C3895088", "aliases": ["upregulation of SUMO conjugating enzyme activity", "up regulation of SUMO conjugating enzyme activity", "up-regulation of SUMO conjugating enzyme activity"], "types": ["T044"], "canonical_name": "positive regulation of SUMO conjugating enzyme activity"}
{"concept_id": "C3895105", "aliases": ["regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential", "regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential"], "types": ["T038"], "canonical_name": "regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "definition": "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493]"}
{"concept_id": "C3895106", "aliases": ["down regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "down regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential", "down-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "downregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "down regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "downregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential", "down-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "negative regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "down-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "downregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "downregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "negative regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "downregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "negative regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "down regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "down-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential", "down-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "down regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization"], "types": ["T038"], "canonical_name": "negative regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493]"}
{"concept_id": "C3895107", "aliases": ["inhibition of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "inhibition of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "inhibition of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "inhibition of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential"], "types": ["T038"], "canonical_name": "inhibition of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential"}
{"concept_id": "C3895108", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential"}
{"concept_id": "C3895109", "aliases": ["up-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "up regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "positive regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "positive regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "up regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "up regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential", "upregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "positive regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential", "upregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "upregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "up-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "up-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "positive regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "up-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential", "upregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential", "up regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "up-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential", "upregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "up regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization"], "types": ["T038"], "canonical_name": "positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "definition": "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493]"}
{"concept_id": "C3895110", "aliases": ["activation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "activation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential", "activation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential", "activation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential"], "types": ["T038"], "canonical_name": "activation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential"}
{"concept_id": "C3895111", "aliases": ["innexin channel activity involved in cell communication by electrical coupling"], "types": ["T044"], "canonical_name": "gap junction channel activity involved in cell communication by electrical coupling", "definition": "Any gap junction channel activity that is involved in cell communication by electrical coupling. [GO_REF:0000061, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:24587307]"}
{"concept_id": "C3895112", "aliases": [], "types": ["T044"], "canonical_name": "connexin involved in cell communication by electrical coupling"}
{"concept_id": "C3895113", "aliases": [], "types": ["T044"], "canonical_name": "innexin involved in cell communication by electrical coupling"}
{"concept_id": "C3895114", "aliases": [], "types": ["T043"], "canonical_name": "regulation of potassium ion export across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]"}
{"concept_id": "C3895115", "aliases": [], "types": ["T043"], "canonical_name": "regulation of potassium export across plasma membrane"}
{"concept_id": "C3895116", "aliases": ["inhibition of potassium ion export across plasma membrane", "downregulation of potassium ion export across plasma membrane", "down-regulation of potassium ion export across plasma membrane", "down regulation of potassium ion export across plasma membrane"], "types": ["T043"], "canonical_name": "negative regulation of potassium ion export across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]"}
{"concept_id": "C3895118", "aliases": ["up regulation of potassium ion export across plasma membrane", "upregulation of potassium ion export across plasma membrane", "up-regulation of potassium ion export across plasma membrane"], "types": ["T043"], "canonical_name": "positive regulation of potassium ion export across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]"}
{"concept_id": "C3895119", "aliases": [], "types": ["T043"], "canonical_name": "activation of potassium ion export across plasma membrane"}
{"concept_id": "C3895120", "aliases": ["sweet taste receptor complex location"], "types": ["T026"], "canonical_name": "sweet taste receptor complex", "definition": "A protein complex which is capable of sweet taste receptor activity. [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576]"}
{"concept_id": "C3895121", "aliases": ["taste receptor complex location"], "types": ["T026"], "canonical_name": "taste receptor complex", "definition": "A protein complex which is capable of taste receptor activity. [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576]"}
{"concept_id": "C3895122", "aliases": ["downregulation of bone marrow cell proliferation", "downregulation of cell proliferation in bone marrow", "down-regulation of bone marrow cell proliferation", "down regulation of bone marrow cell proliferation", "negative regulation of bone marrow cell proliferation", "down-regulation of cell proliferation in bone marrow", "down regulation of cell proliferation in bone marrow"], "types": ["T043"], "canonical_name": "negative regulation of cell proliferation in bone marrow", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in bone marrow. [GO_REF:0000058, GOC:TermGenie, PMID:9241534]"}
{"concept_id": "C3895123", "aliases": ["inhibition of cell proliferation in bone marrow"], "types": ["T043"], "canonical_name": "inhibition of bone marrow cell proliferation"}
{"concept_id": "C3895124", "aliases": ["downregulation of beta-D-lactosidase activity", "down regulation of beta-lactosidase activity", "negative regulation of beta-D-galactanase activity", "down-regulation of beta-D-lactosidase activity", "down regulation of beta-galactosidase activity", "downregulation of beta-D-galactanase activity", "negative regulation of trilactase activity", "negative regulation of exo-(1->4)-beta-D-galactanase activity", "down-regulation of beta-galactosidase activity", "down regulation of beta-D-galactanase activity", "downregulation of beta-galactosidase activity", "down-regulation of beta-lactosidase activity", "down-regulation of beta-D-galactoside galactohydrolase activity", "downregulation of beta-lactosidase activity", "down-regulation of beta-D-galactanase activity", "downregulation of exo-(1->4)-beta-D-galactanase activity", "negative regulation of beta-lactosidase activity", "negative regulation of beta-D-lactosidase activity", "down regulation of beta-D-galactoside galactohydrolase activity", "down-regulation of trilactase activity", "downregulation of trilactase activity", "down regulation of exo-(1->4)-beta-D-galactanase activity", "down regulation of beta-D-lactosidase activity", "negative regulation of beta-D-galactoside galactohydrolase activity", "downregulation of beta-D-galactoside galactohydrolase activity", "down-regulation of exo-(1->4)-beta-D-galactanase activity", "down regulation of trilactase activity"], "types": ["T044"], "canonical_name": "negative regulation of beta-galactosidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518]"}
{"concept_id": "C3895125", "aliases": ["downregulation of hydrolact", "down-regulation of hydrolact"], "types": ["T044"], "canonical_name": "down regulation of hydrolact"}
{"concept_id": "C3895126", "aliases": ["downregulation of lactose hydrolysis", "down-regulation of lactose hydrolysis"], "types": ["T044"], "canonical_name": "down regulation of lactose hydrolysis"}
{"concept_id": "C3895127", "aliases": ["downregulation of lactozym", "down-regulation of lactozym"], "types": ["T044"], "canonical_name": "down regulation of lactozym"}
{"concept_id": "C3895128", "aliases": ["downregulation of maxilact", "down-regulation of maxilact"], "types": ["T044"], "canonical_name": "down regulation of maxilact"}
{"concept_id": "C3895129", "aliases": ["downregulation of oryzatym", "down-regulation of oryzatym"], "types": ["T044"], "canonical_name": "down regulation of oryzatym"}
{"concept_id": "C3895130", "aliases": ["downregulation of S 2107", "down-regulation of S 2107"], "types": ["T044"], "canonical_name": "down regulation of S 2107"}
{"concept_id": "C3895131", "aliases": ["down-regulation of sumiklat", "downregulation of sumiklat"], "types": ["T044"], "canonical_name": "down regulation of sumiklat"}
{"concept_id": "C3895132", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of beta-D-galactanase activity"}
{"concept_id": "C3895133", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of beta-D-galactoside galactohydrolase activity"}
{"concept_id": "C3895134", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of beta-D-lactosidase activity"}
{"concept_id": "C3895135", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of beta-galactosidase activity"}
{"concept_id": "C3895136", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of beta-lactosidase activity"}
{"concept_id": "C3895137", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of exo-(1->4)-beta-D-galactanase activity"}
{"concept_id": "C3895138", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hydrolact"}
{"concept_id": "C3895139", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lactose hydrolysis"}
{"concept_id": "C3895140", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lactozym"}
{"concept_id": "C3895141", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of maxilact"}
{"concept_id": "C3895142", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of oryzatym"}
{"concept_id": "C3895143", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of S 2107"}
{"concept_id": "C3895144", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sumiklat"}
{"concept_id": "C3895145", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of trilactase activity"}
{"concept_id": "C3895146", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of hydrolact"}
{"concept_id": "C3895147", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lactose hydrolysis"}
{"concept_id": "C3895148", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lactozym"}
{"concept_id": "C3895149", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of maxilact"}
{"concept_id": "C3895150", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of oryzatym"}
{"concept_id": "C3895151", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of S 2107"}
{"concept_id": "C3895152", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of sumiklat"}
{"concept_id": "C3895153", "aliases": ["up regulation of beta-D-lactosidase activity", "upregulation of beta-D-galactanase activity", "up regulation of beta-galactosidase activity", "up regulation of beta-lactosidase activity", "up-regulation of beta-lactosidase activity", "positive regulation of trilactase activity", "up-regulation of beta-D-lactosidase activity", "upregulation of beta-lactosidase activity", "positive regulation of exo-(1->4)-beta-D-galactanase activity", "upregulation of beta-galactosidase activity", "positive regulation of beta-D-galactoside galactohydrolase activity", "upregulation of trilactase activity", "up-regulation of beta-D-galactoside galactohydrolase activity", "positive regulation of beta-D-galactanase activity", "upregulation of beta-D-galactoside galactohydrolase activity", "positive regulation of beta-lactosidase activity", "up regulation of beta-D-galactoside galactohydrolase activity", "up regulation of beta-D-galactanase activity", "upregulation of exo-(1->4)-beta-D-galactanase activity", "up-regulation of trilactase activity", "positive regulation of beta-D-lactosidase activity", "up-regulation of exo-(1->4)-beta-D-galactanase activity", "up-regulation of beta-D-galactanase activity", "up regulation of trilactase activity", "up-regulation of beta-galactosidase activity", "up regulation of exo-(1->4)-beta-D-galactanase activity", "upregulation of beta-D-lactosidase activity"], "types": ["T044"], "canonical_name": "positive regulation of beta-galactosidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518]"}
{"concept_id": "C3895154", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-D-galactanase activity"}
{"concept_id": "C3895155", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-D-galactoside galactohydrolase activity"}
{"concept_id": "C3895156", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-D-lactosidase activity"}
{"concept_id": "C3895157", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-galactosidase activity"}
{"concept_id": "C3895158", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-lactosidase activity"}
{"concept_id": "C3895159", "aliases": [], "types": ["T044"], "canonical_name": "activation of exo-(1->4)-beta-D-galactanase activity"}
{"concept_id": "C3895160", "aliases": [], "types": ["T044"], "canonical_name": "activation of hydrolact"}
{"concept_id": "C3895161", "aliases": [], "types": ["T044"], "canonical_name": "activation of lactose hydrolysis"}
{"concept_id": "C3895162", "aliases": [], "types": ["T044"], "canonical_name": "activation of lactozym"}
{"concept_id": "C3895163", "aliases": [], "types": ["T044"], "canonical_name": "activation of maxilact"}
{"concept_id": "C3895164", "aliases": [], "types": ["T044"], "canonical_name": "activation of oryzatym"}
{"concept_id": "C3895165", "aliases": [], "types": ["T044"], "canonical_name": "activation of S 2107"}
{"concept_id": "C3895166", "aliases": [], "types": ["T044"], "canonical_name": "activation of sumiklat"}
{"concept_id": "C3895167", "aliases": [], "types": ["T044"], "canonical_name": "activation of trilactase activity"}
{"concept_id": "C3895168", "aliases": ["upregulation of hydrolact", "up-regulation of hydrolact", "up regulation of hydrolact"], "types": ["T044"], "canonical_name": "positive regulation of hydrolact"}
{"concept_id": "C3895169", "aliases": ["upregulation of lactose hydrolysis", "up regulation of lactose hydrolysis", "up-regulation of lactose hydrolysis"], "types": ["T044"], "canonical_name": "positive regulation of lactose hydrolysis"}
{"concept_id": "C3895170", "aliases": ["up-regulation of lactozym", "up regulation of lactozym", "upregulation of lactozym"], "types": ["T044"], "canonical_name": "positive regulation of lactozym"}
{"concept_id": "C3895171", "aliases": ["up regulation of maxilact", "up-regulation of maxilact", "upregulation of maxilact"], "types": ["T044"], "canonical_name": "positive regulation of maxilact"}
{"concept_id": "C3895172", "aliases": ["up-regulation of oryzatym", "upregulation of oryzatym", "up regulation of oryzatym"], "types": ["T044"], "canonical_name": "positive regulation of oryzatym"}
{"concept_id": "C3895173", "aliases": ["up regulation of S 2107", "up-regulation of S 2107", "upregulation of S 2107"], "types": ["T044"], "canonical_name": "positive regulation of S 2107"}
{"concept_id": "C3895174", "aliases": ["up regulation of sumiklat", "up-regulation of sumiklat", "upregulation of sumiklat"], "types": ["T044"], "canonical_name": "positive regulation of sumiklat"}
{"concept_id": "C3895175", "aliases": [], "types": ["T043"], "canonical_name": "regulation of viral budding via host ESCRT complex", "definition": "Any process that modulates the frequency, rate or extent of viral budding via host ESCRT complex. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737]"}
{"concept_id": "C3895176", "aliases": [], "types": ["T043"], "canonical_name": "regulation of host-assisted viral budding"}
{"concept_id": "C3895177", "aliases": [], "types": ["T043"], "canonical_name": "regulation of viral budding through the ESCRT machinery"}
{"concept_id": "C3895178", "aliases": ["downregulation of viral budding via host ESCRT complex", "down-regulation of viral budding via host ESCRT complex", "down regulation of viral budding via host ESCRT complex"], "types": ["T043"], "canonical_name": "negative regulation of viral budding via host ESCRT complex", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of viral budding via host ESCRT complex. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737]"}
{"concept_id": "C3895179", "aliases": ["negative regulation of viral budding through the ESCRT machinery", "down-regulation of viral budding through the ESCRT machinery", "downregulation of viral budding through the ESCRT machinery"], "types": ["T043"], "canonical_name": "down regulation of viral budding through the ESCRT machinery"}
{"concept_id": "C3895180", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of viral budding through the ESCRT machinery"}
{"concept_id": "C3895181", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of viral budding via host ESCRT complex"}
{"concept_id": "C3895182", "aliases": ["upregulation of viral budding via host ESCRT complex", "up regulation of viral budding via host ESCRT complex", "up-regulation of viral budding via host ESCRT complex"], "types": ["T043"], "canonical_name": "positive regulation of viral budding via host ESCRT complex", "definition": "Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737]"}
{"concept_id": "C3895183", "aliases": [], "types": ["T043"], "canonical_name": "activation of viral budding through the ESCRT machinery"}
{"concept_id": "C3895184", "aliases": [], "types": ["T043"], "canonical_name": "activation of viral budding via host ESCRT complex"}
{"concept_id": "C3895185", "aliases": ["up regulation of viral budding through the ESCRT machinery", "upregulation of viral budding through the ESCRT machinery", "up-regulation of viral budding through the ESCRT machinery"], "types": ["T043"], "canonical_name": "positive regulation of viral budding through the ESCRT machinery"}
{"concept_id": "C3895186", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA double-strand break processing", "definition": "Any process that modulates the frequency, rate or extent of DNA double-strand break processing. [GO_REF:0000058, GOC:TermGenie, PMID:25203555]"}
{"concept_id": "C3895187", "aliases": [], "types": ["T043"], "canonical_name": "regulation of double-strand break repair via single-strand annealing, removal of nonhomologous ends", "definition": "Any process that modulates the frequency, rate or extent of double-strand break repair via single-strand annealing, removal of nonhomologous ends. [GO_REF:0000058, GOC:TermGenie, PMID:25203555]"}
{"concept_id": "C3895188", "aliases": [], "types": ["T044"], "canonical_name": "melibiose binding", "definition": "Binding to melibiose. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:11471732]"}
{"concept_id": "C3895189", "aliases": ["protein localisation in vacuolar membrane", "protein localisation to vacuolar membrane", "protein localization in vacuolar membrane"], "types": ["T043"], "canonical_name": "protein localization to vacuolar membrane", "definition": "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. [GO_REF:0000087, GOC:TermGenie, PMID:25378562]"}
{"concept_id": "C3895190", "aliases": [], "types": ["T038"], "canonical_name": "regulation of cardiac conduction", "definition": "Any process that modulates the frequency, rate or extent of cardiac conduction. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]"}
{"concept_id": "C3895191", "aliases": ["down regulation of cardiac conduction", "downregulation of cardiac conduction", "down-regulation of cardiac conduction"], "types": ["T038"], "canonical_name": "negative regulation of cardiac conduction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]"}
{"concept_id": "C3895192", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of cardiac conduction"}
{"concept_id": "C3895193", "aliases": ["up-regulation of cardiac conduction", "up regulation of cardiac conduction", "upregulation of cardiac conduction"], "types": ["T038"], "canonical_name": "positive regulation of cardiac conduction", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac conduction. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]"}
{"concept_id": "C3895194", "aliases": [], "types": ["T038"], "canonical_name": "activation of cardiac conduction"}
{"concept_id": "C3895195", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sodium ion import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of sodium ion import across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779]"}
{"concept_id": "C3895196", "aliases": ["down-regulation of sodium ion import across plasma membrane", "downregulation of sodium ion import across plasma membrane", "down regulation of sodium ion import across plasma membrane"], "types": ["T043"], "canonical_name": "negative regulation of sodium ion import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion import across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779]"}
{"concept_id": "C3895197", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sodium ion import across plasma membrane"}
{"concept_id": "C3895198", "aliases": ["up-regulation of sodium ion import across plasma membrane", "upregulation of sodium ion import across plasma membrane", "up regulation of sodium ion import across plasma membrane"], "types": ["T043"], "canonical_name": "positive regulation of sodium ion import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of sodium ion import across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779]"}
{"concept_id": "C3895199", "aliases": [], "types": ["T043"], "canonical_name": "activation of sodium ion import across plasma membrane"}
{"concept_id": "C3895200", "aliases": [], "types": ["T043"], "canonical_name": "L-valine transmembrane transport", "definition": "The directed movement of L-valine across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:20944394]"}
{"concept_id": "C3895201", "aliases": ["regulation of glutathione formation", "regulation of glutathione biosynthesis", "regulation of glutathione synthesis", "regulation of glutathione anabolism"], "types": ["T044"], "canonical_name": "regulation of glutathione biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of glutathione biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3895202", "aliases": ["down regulation of glutathione anabolism", "downregulation of glutathione formation", "negative regulation of glutathione formation", "negative regulation of glutathione biosynthesis", "down-regulation of glutathione biosynthetic process", "negative regulation of glutathione anabolism", "down-regulation of glutathione biosynthesis", "down-regulation of glutathione anabolism", "negative regulation of glutathione synthesis", "down-regulation of glutathione synthesis", "down regulation of glutathione biosynthetic process", "downregulation of glutathione biosynthetic process", "down-regulation of glutathione formation", "downregulation of glutathione synthesis", "down regulation of glutathione synthesis", "downregulation of glutathione biosynthesis", "down regulation of glutathione formation", "downregulation of glutathione anabolism", "down regulation of glutathione biosynthesis"], "types": ["T044"], "canonical_name": "negative regulation of glutathione biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glutathione biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3895203", "aliases": ["inhibition of glutathione biosynthesis", "inhibition of glutathione synthesis", "inhibition of glutathione formation", "inhibition of glutathione biosynthetic process"], "types": ["T044"], "canonical_name": "inhibition of glutathione anabolism"}
{"concept_id": "C3895204", "aliases": ["positive regulation of glutathione biosynthesis", "up-regulation of glutathione biosynthetic process", "up regulation of glutathione anabolism", "up regulation of glutathione biosynthetic process", "upregulation of glutathione anabolism", "up-regulation of glutathione anabolism", "up regulation of glutathione biosynthesis", "upregulation of glutathione biosynthesis", "up regulation of glutathione formation", "upregulation of glutathione biosynthetic process", "positive regulation of glutathione synthesis", "upregulation of glutathione synthesis", "up-regulation of glutathione synthesis", "up-regulation of glutathione biosynthesis", "positive regulation of glutathione anabolism", "positive regulation of glutathione formation", "up-regulation of glutathione formation", "upregulation of glutathione formation", "up regulation of glutathione synthesis"], "types": ["T044"], "canonical_name": "positive regulation of glutathione biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3895205", "aliases": ["activation of glutathione synthesis", "activation of glutathione biosynthesis", "activation of glutathione biosynthetic process", "activation of glutathione formation"], "types": ["T044"], "canonical_name": "activation of glutathione anabolism"}
{"concept_id": "C3895206", "aliases": ["regulation of amino acid membrane transport"], "types": ["T044"], "canonical_name": "regulation of amino acid transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:16115814]"}
{"concept_id": "C3895207", "aliases": ["guanyl nucleotide transmembrane transport"], "types": ["T043"], "canonical_name": "guanine nucleotide transmembrane transport", "definition": "The process in which a guanyl nucleotide is transported across a membrane. [GO_REF:0000069, GOC:dph, GOC:TermGenie, GOC:vw, PMID:25320081]"}
{"concept_id": "C3895208", "aliases": [], "types": ["T043"], "canonical_name": "uracil transmembrane transport", "definition": "The process in which uracil is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:8948441]"}
{"concept_id": "C3895209", "aliases": ["downregulation of anion transport", "down regulation of anion transport", "down-regulation of anion transport"], "types": ["T043"], "canonical_name": "negative regulation of anion transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. [GO_REF:0000058, GOC:TermGenie, PMID:11336802]"}
{"concept_id": "C3895210", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of anion transport"}
{"concept_id": "C3895211", "aliases": ["upregulation of anion transport", "up-regulation of anion transport", "up regulation of anion transport"], "types": ["T043"], "canonical_name": "positive regulation of anion transport", "definition": "Any process that activates or increases the frequency, rate or extent of anion transport. [GO_REF:0000058, GOC:TermGenie, PMID:11336802]"}
{"concept_id": "C3895212", "aliases": [], "types": ["T043"], "canonical_name": "activation of anion transport"}
{"concept_id": "C3895213", "aliases": [], "types": ["T044"], "canonical_name": "cortisol binding", "definition": "Binding to cortisol. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:18483153]"}
{"concept_id": "C3895214", "aliases": ["regulation of transmembrane inorganic anion transport", "regulation of inorganic anion membrane transport"], "types": ["T043"], "canonical_name": "regulation of inorganic anion transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:11336802]"}
{"concept_id": "C3895215", "aliases": ["down regulation of inorganic anion transmembrane transport", "downregulation of inorganic anion membrane transport", "negative regulation of transmembrane inorganic anion transport", "down regulation of transmembrane inorganic anion transport", "downregulation of transmembrane inorganic anion transport", "down-regulation of inorganic anion transmembrane transport", "down-regulation of inorganic anion membrane transport", "down-regulation of transmembrane inorganic anion transport", "negative regulation of inorganic anion membrane transport", "down regulation of inorganic anion membrane transport", "downregulation of inorganic anion transmembrane transport"], "types": ["T043"], "canonical_name": "negative regulation of inorganic anion transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:11336802]"}
{"concept_id": "C3895216", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of inorganic anion membrane transport"}
{"concept_id": "C3895217", "aliases": ["inhibition of transmembrane inorganic anion transport"], "types": ["T043"], "canonical_name": "inhibition of inorganic anion transmembrane transport"}
{"concept_id": "C3895218", "aliases": ["up regulation of transmembrane inorganic anion transport", "up-regulation of inorganic anion membrane transport", "up regulation of inorganic anion transmembrane transport", "positive regulation of transmembrane inorganic anion transport", "up regulation of inorganic anion membrane transport", "positive regulation of inorganic anion membrane transport", "upregulation of inorganic anion transmembrane transport", "up-regulation of inorganic anion transmembrane transport", "upregulation of inorganic anion membrane transport", "up-regulation of transmembrane inorganic anion transport", "upregulation of transmembrane inorganic anion transport"], "types": ["T043"], "canonical_name": "positive regulation of inorganic anion transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:11336802]"}
{"concept_id": "C3895219", "aliases": [], "types": ["T043"], "canonical_name": "activation of inorganic anion membrane transport"}
{"concept_id": "C3895220", "aliases": ["activation of transmembrane inorganic anion transport"], "types": ["T043"], "canonical_name": "activation of inorganic anion transmembrane transport"}
{"concept_id": "C3895221", "aliases": ["regulation of production of microRNAs involved in gene silencing by microRNA", "regulation of gene silencing by miRNA, production of miRNAs", "regulation of production of miRNAs involved in gene silencing by miRNA", "regulation of microRNA-mediated gene silencing, production of microRNAs", "regulation of miRNA-mediated gene silencing, production of miRNAs", "regulation of miRNA processing"], "types": ["T045"], "canonical_name": "regulation of miRNA maturation", "definition": "Any process that modulates the frequency, rate or extent of maturation of miRNAs. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]"}
{"concept_id": "C3895222", "aliases": ["regulation of microRNA biogenesis", "regulation of microRNA biosynthetic process", "regulation of microRNA biosynthesis"], "types": ["T045"], "canonical_name": "regulation of miRNA biogenesis"}
{"concept_id": "C3895223", "aliases": [], "types": ["T045"], "canonical_name": "regulation of microRNA metabolism"}
{"concept_id": "C3895224", "aliases": [], "types": ["T045"], "canonical_name": "regulation of microRNA processing"}
{"concept_id": "C3895225", "aliases": ["downregulation of production of miRNAs involved in gene silencing by miRNA", "negative regulation of microRNA-mediated gene silencing, production of microRNAs", "negative regulation of miRNA processing", "down regulation of miRNA-mediated gene silencing, production of miRNAs", "down-regulation of production of microRNAs involved in gene silencing by microRNA", "downregulation of gene silencing by miRNA, production of miRNAs", "down regulation of production of miRNAs involved in gene silencing by miRNA", "down regulation of production of microRNAs involved in gene silencing by microRNA", "negative regulation of miRNA-mediated gene silencing, production of miRNAs", "downregulation of miRNA-mediated gene silencing, production of miRNAs", "down regulation of miRNA processing", "down-regulation of microRNA-mediated gene silencing, production of microRNAs", "negative regulation of production of microRNAs involved in gene silencing by microRNA", "down-regulation of production of miRNAs involved in gene silencing by miRNA", "down-regulation of miRNA processing", "down-regulation of miRNA-mediated gene silencing, production of miRNAs", "negative regulation of gene silencing by miRNA, production of miRNAs", "down-regulation of gene silencing by miRNA, production of miRNAs", "downregulation of microRNA-mediated gene silencing, production of microRNAs", "negative regulation of production of miRNAs involved in gene silencing by miRNA", "downregulation of miRNA processing", "downregulation of production of microRNAs involved in gene silencing by microRNA", "down regulation of microRNA-mediated gene silencing, production of microRNAs", "down regulation of gene silencing by miRNA, production of miRNAs"], "types": ["T045"], "canonical_name": "negative regulation of miRNA maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maturation of miRNAs. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]"}
{"concept_id": "C3895226", "aliases": ["down regulation of microRNA biosynthesis", "downregulation of miRNA biogenesis", "down-regulation of miRNA biogenesis", "down-regulation of microRNA biogenesis", "down-regulation of microRNA biosynthesis", "down regulation of microRNA metabolic process", "down-regulation of microRNA biosynthetic process", "downregulation of microRNA biogenesis", "down regulation of microRNA biogenesis", "downregulation of microRNA biosynthetic process", "down regulation of microRNA biosynthetic process", "downregulation of microRNA biosynthesis"], "types": ["T045"], "canonical_name": "down regulation of miRNA biogenesis"}
{"concept_id": "C3895227", "aliases": ["down-regulation of microRNA metabolic process", "down-regulation of microRNA metabolism"], "types": ["T045"], "canonical_name": "down regulation of microRNA metabolism"}
{"concept_id": "C3895228", "aliases": ["downregulation of microRNA metabolism"], "types": ["T045"], "canonical_name": "downregulation of microRNA metabolic process"}
{"concept_id": "C3895229", "aliases": ["inhibition of production of miRNAs involved in gene silencing by miRNA", "inhibition of production of microRNAs involved in gene silencing by microRNA", "inhibition of miRNA-mediated gene silencing, production of miRNAs", "inhibition of microRNA-mediated gene silencing, production of microRNAs"], "types": ["T045"], "canonical_name": "inhibition of gene silencing by miRNA, production of miRNAs"}
{"concept_id": "C3895230", "aliases": ["inhibition of microRNA biogenesis", "inhibition of microRNA biosynthesis", "inhibition of microRNA biosynthetic process"], "types": ["T045"], "canonical_name": "inhibition of miRNA biogenesis"}
{"concept_id": "C3895231", "aliases": ["inhibition of microRNA metabolism"], "types": ["T045"], "canonical_name": "inhibition of microRNA metabolic process"}
{"concept_id": "C3895232", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of miRNA processing"}
{"concept_id": "C3895233", "aliases": ["negative regulation of microRNA biogenesis", "negative regulation of microRNA biosynthesis", "negative regulation of microRNA biosynthetic process"], "types": ["T045"], "canonical_name": "negative regulation of miRNA biogenesis"}
{"concept_id": "C3895234", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of microRNA metabolism"}
{"concept_id": "C3895235", "aliases": ["up-regulation of miRNA-mediated gene silencing, production of miRNAs", "positive regulation of microRNA-mediated gene silencing, production of microRNAs", "positive regulation of gene silencing by miRNA, production of miRNAs", "positive regulation of miRNA-mediated gene silencing, production of miRNAs", "positive regulation of miRNA processing", "upregulation of microRNA-mediated gene silencing, production of microRNAs", "up regulation of miRNA processing", "up-regulation of miRNA processing", "up regulation of production of microRNAs involved in gene silencing by microRNA", "upregulation of production of miRNAs involved in gene silencing by miRNA", "up regulation of miRNA-mediated gene silencing, production of miRNAs", "up regulation of gene silencing by miRNA, production of miRNAs", "up-regulation of gene silencing by miRNA, production of miRNAs", "up-regulation of production of microRNAs involved in gene silencing by microRNA", "upregulation of gene silencing by miRNA, production of miRNAs", "positive regulation of production of miRNAs involved in gene silencing by miRNA", "upregulation of production of microRNAs involved in gene silencing by microRNA", "up-regulation of production of miRNAs involved in gene silencing by miRNA", "positive regulation of production of microRNAs involved in gene silencing by microRNA", "upregulation of miRNA processing", "up regulation of production of miRNAs involved in gene silencing by miRNA", "up-regulation of microRNA-mediated gene silencing, production of microRNAs", "up regulation of microRNA-mediated gene silencing, production of microRNAs", "upregulation of miRNA-mediated gene silencing, production of miRNAs"], "types": ["T045"], "canonical_name": "positive regulation of miRNA maturation", "definition": "Any process that activates or increases the frequency, rate or extent of maturation of miRNAs. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]"}
{"concept_id": "C3895236", "aliases": [], "types": ["T045"], "canonical_name": "activation of gene silencing by miRNA, production of miRNAs"}
{"concept_id": "C3895237", "aliases": ["activation of microRNA biosynthesis", "activation of microRNA biosynthetic process", "activation of microRNA biogenesis"], "types": ["T045"], "canonical_name": "activation of miRNA biogenesis"}
{"concept_id": "C3895238", "aliases": ["activation of microRNA metabolism"], "types": ["T045"], "canonical_name": "activation of microRNA metabolic process"}
{"concept_id": "C3895239", "aliases": ["activation of production of microRNAs involved in gene silencing by microRNA", "activation of microRNA-mediated gene silencing, production of microRNAs", "activation of production of miRNAs involved in gene silencing by miRNA"], "types": ["T045"], "canonical_name": "activation of miRNA-mediated gene silencing, production of miRNAs"}
{"concept_id": "C3895240", "aliases": [], "types": ["T045"], "canonical_name": "activation of miRNA processing"}
{"concept_id": "C3895241", "aliases": ["up regulation of microRNA biogenesis", "upregulation of microRNA biogenesis", "up-regulation of microRNA biosynthetic process", "positive regulation of microRNA biogenesis", "upregulation of microRNA biosynthetic process", "up regulation of microRNA biosynthetic process", "up regulation of miRNA biogenesis", "up-regulation of microRNA biosynthesis", "positive regulation of microRNA biosynthesis", "upregulation of miRNA biogenesis", "up-regulation of miRNA biogenesis", "upregulation of microRNA biosynthesis", "up regulation of microRNA biosynthesis", "positive regulation of microRNA biosynthetic process", "up-regulation of microRNA biogenesis"], "types": ["T045"], "canonical_name": "positive regulation of miRNA biogenesis"}
{"concept_id": "C3895242", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of microRNA metabolism"}
{"concept_id": "C3895243", "aliases": ["up-regulation of microRNA metabolism", "up regulation of microRNA metabolism", "up-regulation of microRNA metabolic process"], "types": ["T045"], "canonical_name": "up regulation of microRNA metabolic process"}
{"concept_id": "C3895244", "aliases": ["upregulation of microRNA metabolism"], "types": ["T045"], "canonical_name": "upregulation of microRNA metabolic process"}
{"concept_id": "C3895246", "aliases": ["L-glutamine import into cell", "L-glutamine uptake"], "types": ["T043"], "canonical_name": "L-glutamine import across plasma membrane", "definition": "The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]"}
{"concept_id": "C3895247", "aliases": ["glycine import into cell"], "types": ["T043"], "canonical_name": "glycine import across plasma membrane", "definition": "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]"}
{"concept_id": "C3895248", "aliases": ["L-valine import into cell"], "types": ["T043"], "canonical_name": "L-valine import across plasma membrane", "definition": "The directed movement of L-valine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]"}
{"concept_id": "C3895249", "aliases": ["L-isoleucine import into cell"], "types": ["T043"], "canonical_name": "L-isoleucine import across plasma membrane", "definition": "The directed movement of L-isoleucine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]"}
{"concept_id": "C3895250", "aliases": ["L-threonine uptake", "L-threonine import into cell"], "types": ["T043"], "canonical_name": "L-threonine import across plasma membrane", "definition": "The directed movement of L-threonine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]"}
{"concept_id": "C3895251", "aliases": ["L-tyrosine import into cell", "L-tyrosine uptake"], "types": ["T043"], "canonical_name": "L-tyrosine import across plasma membrane", "definition": "The directed movement of L-tyrosine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]"}
{"concept_id": "C3895253", "aliases": ["L-histidine import into cell"], "types": ["T043"], "canonical_name": "L-histidine import across plasma membrane", "definition": "The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]"}
{"concept_id": "C3895254", "aliases": ["L-asparagine import into cell"], "types": ["T043"], "canonical_name": "L-asparagine import across plasma membrane", "definition": "The directed movement of L-asparagine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]"}
{"concept_id": "C3895255", "aliases": ["L-serine import into cell"], "types": ["T043"], "canonical_name": "L-serine import across plasma membrane", "definition": "The directed movement of L-serine into a cell. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]"}
{"concept_id": "C3895256", "aliases": ["L-methionine import into cell"], "types": ["T043"], "canonical_name": "L-methionine import across plasma membrane", "definition": "The directed movement of L-methionine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:17556368]"}
{"concept_id": "C3895257", "aliases": ["regulation of lymphatic vessel myogenic constriction"], "types": ["T038"], "canonical_name": "regulation of collecting lymphatic vessel constriction", "definition": "Any process that modulates the frequency, rate or extent of collecting lymphatic vessel constriction. [GO_REF:0000058, GOC:TermGenie, PMID:23897233]"}
{"concept_id": "C3895258", "aliases": ["down regulation of collecting lymphatic vessel constriction", "downregulation of lymphatic vessel myogenic constriction", "down-regulation of lymphatic vessel myogenic constriction", "downregulation of collecting lymphatic vessel constriction", "down-regulation of collecting lymphatic vessel constriction", "negative regulation of lymphatic vessel myogenic constriction", "down regulation of lymphatic vessel myogenic constriction"], "types": ["T039"], "canonical_name": "negative regulation of collecting lymphatic vessel constriction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of collecting lymphatic vessel constriction. [GO_REF:0000058, GOC:TermGenie, PMID:23897233]"}
{"concept_id": "C3895259", "aliases": ["inhibition of lymphatic vessel myogenic constriction"], "types": ["T039"], "canonical_name": "inhibition of collecting lymphatic vessel constriction"}
{"concept_id": "C3895260", "aliases": ["up-regulation of collecting lymphatic vessel constriction", "up-regulation of lymphatic vessel myogenic constriction", "upregulation of collecting lymphatic vessel constriction", "up regulation of collecting lymphatic vessel constriction", "positive regulation of lymphatic vessel myogenic constriction", "upregulation of lymphatic vessel myogenic constriction", "up regulation of lymphatic vessel myogenic constriction"], "types": ["T039"], "canonical_name": "positive regulation of collecting lymphatic vessel constriction", "definition": "Any process that activates or increases the frequency, rate or extent of collecting lymphatic vessel constriction. [GO_REF:0000058, GOC:TermGenie, PMID:23897233]"}
{"concept_id": "C3895261", "aliases": ["activation of lymphatic vessel myogenic constriction"], "types": ["T039"], "canonical_name": "activation of collecting lymphatic vessel constriction"}
{"concept_id": "C3895262", "aliases": ["downregulation of voltage-gated potassium channel activity", "negative regulation of voltage-dependent potassium channel activity", "down regulation of voltage-dependent potassium channel activity", "downregulation of voltage-gated potassium ion channel activity", "down-regulation of voltage gated potassium channel activity", "down-regulation of voltage-gated potassium ion channel activity", "down regulation of voltage-sensitive potassium channel", "negative regulation of voltage-sensitive potassium channel", "downregulation of voltage-dependent potassium channel activity", "downregulation of voltage-sensitive potassium channel", "negative regulation of voltage-gated potassium ion channel activity", "down-regulation of voltage-gated potassium channel activity", "negative regulation of voltage gated potassium channel activity", "down-regulation of voltage-sensitive potassium channel", "down regulation of voltage gated potassium channel activity", "down regulation of voltage-gated potassium channel activity", "down-regulation of voltage-dependent potassium channel activity", "down regulation of voltage-gated potassium ion channel activity", "downregulation of voltage gated potassium channel activity"], "types": ["T044"], "canonical_name": "negative regulation of voltage-gated potassium channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:19219384]"}
{"concept_id": "C3895263", "aliases": ["inhibition of voltage-gated potassium ion channel activity", "inhibition of voltage-gated potassium channel activity", "inhibition of voltage-dependent potassium channel activity", "inhibition of voltage-sensitive potassium channel"], "types": ["T044"], "canonical_name": "inhibition of voltage gated potassium channel activity"}
{"concept_id": "C3895264", "aliases": ["up regulation of voltage-dependent potassium channel activity", "positive regulation of voltage gated potassium channel activity", "up-regulation of voltage-gated potassium ion channel activity", "up regulation of voltage-gated potassium channel activity", "up-regulation of voltage-sensitive potassium channel", "positive regulation of voltage-gated potassium ion channel activity", "upregulation of voltage-gated potassium ion channel activity", "up regulation of voltage gated potassium channel activity", "upregulation of voltage-gated potassium channel activity", "upregulation of voltage gated potassium channel activity", "upregulation of voltage-sensitive potassium channel", "up-regulation of voltage-gated potassium channel activity", "positive regulation of voltage-dependent potassium channel activity", "up-regulation of voltage gated potassium channel activity", "positive regulation of voltage-sensitive potassium channel", "up regulation of voltage-gated potassium ion channel activity", "up-regulation of voltage-dependent potassium channel activity", "up regulation of voltage-sensitive potassium channel", "upregulation of voltage-dependent potassium channel activity"], "types": ["T038"], "canonical_name": "positive regulation of voltage-gated potassium channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:19219384]"}
{"concept_id": "C3895265", "aliases": ["activation of voltage-sensitive potassium channel", "activation of voltage-dependent potassium channel activity", "activation of voltage-gated potassium channel activity", "activation of voltage-gated potassium ion channel activity"], "types": ["T038"], "canonical_name": "activation of voltage gated potassium channel activity"}
{"concept_id": "C3895280", "aliases": ["single strand break repair in telomere", "telomeric single strand break repair", "telomere single-strand break repair", "telomere SSBR"], "types": ["T045"], "canonical_name": "telomere single strand break repair", "definition": "Single strand break repair that takes place in a telomere. [GO_REF:0000062, GOC:TermGenie, PMID:24374808]"}
{"concept_id": "C3895281", "aliases": ["down-regulation of telomeric single strand break repair", "negative regulation of single strand break repair in telomere", "down-regulation of telomere single strand break repair", "down regulation of telomere single strand break repair", "downregulation of telomere single-strand break repair", "down-regulation of single strand break repair in telomere", "negative regulation of telomere single-strand break repair", "down regulation of telomere single-strand break repair", "down-regulation of telomere SSBR", "downregulation of telomeric single strand break repair", "downregulation of single strand break repair in telomere", "down regulation of single strand break repair in telomere", "down regulation of telomere SSBR", "down regulation of telomeric single strand break repair", "down-regulation of telomere single-strand break repair", "negative regulation of telomere SSBR", "downregulation of telomere single strand break repair", "downregulation of telomere SSBR", "negative regulation of telomeric single strand break repair"], "types": ["T043"], "canonical_name": "negative regulation of telomere single strand break repair", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomere single strand break repair. [GO_REF:0000058, GOC:TermGenie, PMID:24374808]"}
{"concept_id": "C3895282", "aliases": ["inhibition of telomere single strand break repair", "inhibition of telomere single-strand break repair"], "types": ["T045"], "canonical_name": "inhibition of single strand break repair in telomere"}
{"concept_id": "C3895283", "aliases": ["inhibition of telomeric single strand break repair"], "types": ["T043"], "canonical_name": "inhibition of telomere SSBR"}
{"concept_id": "C3895284", "aliases": [], "types": ["T043"], "canonical_name": "organic acid transmembrane transport", "definition": "The process in which an organic acid is transported across a membrane. [GO_REF:0000069, GOC:TermGenie]"}
{"concept_id": "C3895285", "aliases": [], "types": ["T043"], "canonical_name": "arginine transmembrane transport"}
{"concept_id": "C3895288", "aliases": ["down regulation of cellular protein localisation", "negative regulation of cellular protein localization", "negative regulation of cellular protein localisation", "down-regulation of cellular protein localization", "down regulation of cellular protein localization", "downregulation of cellular protein localisation", "down-regulation of cellular protein localisation", "downregulation of cellular protein localization"], "types": ["T039"], "canonical_name": "negative regulation of protein localization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3895290", "aliases": ["inhibition of cellular protein localization"], "types": ["T043"], "canonical_name": "inhibition of cellular protein localisation"}
{"concept_id": "C3895292", "aliases": ["up-regulation of cellular protein localization", "upregulation of cellular protein localisation", "positive regulation of cellular protein localization", "upregulation of cellular protein localization", "up regulation of cellular protein localization", "positive regulation of cellular protein localisation", "up-regulation of cellular protein localisation", "up regulation of cellular protein localisation"], "types": ["T039"], "canonical_name": "positive regulation of protein localization", "definition": "Any process that activates or increases the frequency, rate or extent of a protein localization. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3895296", "aliases": [], "types": ["T043"], "canonical_name": "magnesium ion transmembrane transport", "definition": "The directed movement of magnesium ion across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:11254124]"}
{"concept_id": "C3895297", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in cellular response to ammonium ion", "definition": "Any signal transduction that is involved in cellular response to ammonium ion. [GO_REF:0000060, GOC:TermGenie, PMID:16297994]"}
{"concept_id": "C3895298", "aliases": ["signalling cascade involved in cellular response to ammonium ion"], "types": ["T043"], "canonical_name": "signaling cascade involved in cellular response to ammonium ion"}
{"concept_id": "C3895299", "aliases": ["signalling pathway involved in cellular response to ammonium ion"], "types": ["T043"], "canonical_name": "signaling pathway involved in cellular response to ammonium ion"}
{"concept_id": "C3895300", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to amino acid starvation", "definition": "Any process that modulates the frequency, rate or extent of cellular response to amino acid starvation. [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840]"}
{"concept_id": "C3895301", "aliases": ["up-regulation of cellular response to amino acid starvation", "up regulation of cellular response to amino acid starvation", "upregulation of cellular response to amino acid starvation"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to amino acid starvation", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation. [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840]"}
{"concept_id": "C3895302", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to amino acid starvation"}
{"concept_id": "C3895303", "aliases": [], "types": ["T044"], "canonical_name": "regulation of APC-fizzy related complex activity"}
{"concept_id": "C3895305", "aliases": ["regulation of mRNA 3' UTR binding"], "types": ["T044"], "canonical_name": "regulation of mRNA 3'-UTR binding", "definition": "Any process that modulates the frequency, rate or extent of mRNA 3'-UTR binding. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]"}
{"concept_id": "C3895306", "aliases": ["downregulation of mRNA 3' UTR binding", "negative regulation of mRNA 3' UTR binding", "down-regulation of mRNA 3'-UTR binding", "down regulation of mRNA 3' UTR binding", "down regulation of mRNA 3'-UTR binding", "down-regulation of mRNA 3' UTR binding", "downregulation of mRNA 3'-UTR binding"], "types": ["T044"], "canonical_name": "negative regulation of mRNA 3'-UTR binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-UTR binding. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]"}
{"concept_id": "C3895307", "aliases": ["inhibition of mRNA 3'-UTR binding"], "types": ["T044"], "canonical_name": "inhibition of mRNA 3' UTR binding"}
{"concept_id": "C3895308", "aliases": ["upregulation of mRNA 3' UTR binding", "up regulation of mRNA 3' UTR binding", "up-regulation of mRNA 3'-UTR binding", "up-regulation of mRNA 3' UTR binding", "positive regulation of mRNA 3' UTR binding", "upregulation of mRNA 3'-UTR binding", "up regulation of mRNA 3'-UTR binding"], "types": ["T044"], "canonical_name": "positive regulation of mRNA 3'-UTR binding", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA 3'-UTR binding. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]"}
{"concept_id": "C3895309", "aliases": ["activation of mRNA 3'-UTR binding"], "types": ["T044"], "canonical_name": "activation of mRNA 3' UTR binding"}
{"concept_id": "C3895310", "aliases": [], "types": ["T043"], "canonical_name": "response to arsenite(3-)", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]"}
{"concept_id": "C3895311", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to arsenite(3-)", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]"}
{"concept_id": "C3895312", "aliases": [], "types": ["T043"], "canonical_name": "response to arsenite ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]"}
{"concept_id": "C3895313", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to arsenite ion", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]"}
{"concept_id": "C3895314", "aliases": ["regulation of cellular response to TGF-beta stimulus", "regulation of cellular response to TGFbeta stimulus"], "types": ["T043"], "canonical_name": "regulation of cellular response to transforming growth factor beta stimulus", "definition": "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]"}
{"concept_id": "C3895315", "aliases": ["down-regulation of cellular response to TGF-beta stimulus", "down regulation of cellular response to TGFbeta stimulus", "negative regulation of cellular response to TGF-beta stimulus", "down-regulation of cellular response to transforming growth factor beta stimulus", "down regulation of cellular response to transforming growth factor beta stimulus", "downregulation of cellular response to transforming growth factor beta stimulus", "downregulation of cellular response to TGFbeta stimulus", "down regulation of cellular response to TGF-beta stimulus", "downregulation of cellular response to TGF-beta stimulus", "down-regulation of cellular response to TGFbeta stimulus", "negative regulation of cellular response to TGFbeta stimulus"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to transforming growth factor beta stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]"}
{"concept_id": "C3895316", "aliases": ["inhibition of cellular response to TGFbeta stimulus", "inhibition of cellular response to transforming growth factor beta stimulus"], "types": ["T043"], "canonical_name": "inhibition of cellular response to TGF-beta stimulus"}
{"concept_id": "C3895317", "aliases": ["up regulation of cellular response to TGFbeta stimulus", "positive regulation of cellular response to TGFbeta stimulus", "up regulation of cellular response to transforming growth factor beta stimulus", "up-regulation of cellular response to transforming growth factor beta stimulus", "up regulation of cellular response to TGF-beta stimulus", "positive regulation of cellular response to TGF-beta stimulus", "upregulation of cellular response to transforming growth factor beta stimulus", "up-regulation of cellular response to TGFbeta stimulus", "up-regulation of cellular response to TGF-beta stimulus", "upregulation of cellular response to TGF-beta stimulus", "upregulation of cellular response to TGFbeta stimulus"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to transforming growth factor beta stimulus", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]"}
{"concept_id": "C3895318", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to TGF-beta stimulus"}
{"concept_id": "C3895319", "aliases": ["activation of cellular response to transforming growth factor beta stimulus"], "types": ["T043"], "canonical_name": "activation of cellular response to TGFbeta stimulus"}
{"concept_id": "C3895320", "aliases": [], "types": ["T038"], "canonical_name": "regulation of aorta morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of aorta morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]"}
{"concept_id": "C3895321", "aliases": ["down-regulation of aorta morphogenesis", "downregulation of aorta morphogenesis", "down regulation of aorta morphogenesis"], "types": ["T038"], "canonical_name": "negative regulation of aorta morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]"}
{"concept_id": "C3895322", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of aorta morphogenesis"}
{"concept_id": "C3895323", "aliases": ["up regulation of aorta morphogenesis", "upregulation of aorta morphogenesis", "up-regulation of aorta morphogenesis"], "types": ["T038"], "canonical_name": "positive regulation of aorta morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]"}
{"concept_id": "C3895324", "aliases": [], "types": ["T038"], "canonical_name": "activation of aorta morphogenesis"}
{"concept_id": "C3895325", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cristae formation", "definition": "Any process that modulates the frequency, rate or extent of cristae formation. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]"}
{"concept_id": "C3895326", "aliases": ["downregulation of cristae formation", "down regulation of cristae formation", "down-regulation of cristae formation"], "types": ["T043"], "canonical_name": "negative regulation of cristae formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cristae formation. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]"}
{"concept_id": "C3895327", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cristae formation"}
{"concept_id": "C3895328", "aliases": ["up regulation of cristae formation", "up-regulation of cristae formation", "upregulation of cristae formation"], "types": ["T043"], "canonical_name": "positive regulation of cristae formation", "definition": "Any process that activates or increases the frequency, rate or extent of cristae formation. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]"}
{"concept_id": "C3895329", "aliases": [], "types": ["T043"], "canonical_name": "activation of cristae formation"}
{"concept_id": "C3895330", "aliases": ["regulation of stress response to copper", "regulation of response to copper ion stress"], "types": ["T039"], "canonical_name": "regulation of stress response to copper ion", "definition": "Any process that modulates the frequency, rate or extent of stress response to copper ion. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011]"}
{"concept_id": "C3895331", "aliases": [], "types": ["T039"], "canonical_name": "regulation of response to copper toxicity"}
{"concept_id": "C3895332", "aliases": ["downregulation of response to copper ion stress", "down regulation of response to copper ion stress", "downregulation of stress response to copper ion", "negative regulation of response to copper ion stress", "down-regulation of stress response to copper ion", "down-regulation of response to copper ion stress", "down regulation of stress response to copper ion"], "types": ["T039"], "canonical_name": "negative regulation of stress response to copper ion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of stress response to copper ion. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011]"}
{"concept_id": "C3895333", "aliases": ["down-regulation of response to copper toxicity", "downregulation of response to copper toxicity"], "types": ["T039"], "canonical_name": "down regulation of response to copper toxicity"}
{"concept_id": "C3895334", "aliases": ["negative regulation of response to copper toxicity"], "types": ["T039"], "canonical_name": "inhibition of response to copper toxicity"}
{"concept_id": "C3895335", "aliases": ["inhibition of stress response to copper ion"], "types": ["T039"], "canonical_name": "inhibition of response to copper ion stress"}
{"concept_id": "C3895336", "aliases": ["upregulation of stress response to copper ion", "up regulation of stress response to copper ion", "up-regulation of stress response to copper ion", "upregulation of response to copper ion stress", "up-regulation of response to copper ion stress", "up regulation of response to copper ion stress", "positive regulation of response to copper ion stress"], "types": ["T039"], "canonical_name": "positive regulation of stress response to copper ion", "definition": "Any process that activates or increases the frequency, rate or extent of stress response to copper ion. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011]"}
{"concept_id": "C3895337", "aliases": ["activation of stress response to copper ion"], "types": ["T039"], "canonical_name": "activation of response to copper ion stress"}
{"concept_id": "C3895338", "aliases": ["upregulation of response to copper toxicity", "up-regulation of response to copper toxicity", "up regulation of response to copper toxicity", "positive regulation of response to copper toxicity"], "types": ["T039"], "canonical_name": "activation of response to copper toxicity"}
{"concept_id": "C3895339", "aliases": ["regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity", "regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity", "regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity"], "types": ["T044"], "canonical_name": "regulation of cytokinin dehydrogenase activity", "definition": "Any process that modulates the frequency, rate or extent of cytokinin dehydrogenase activity. [GO_REF:0000059, GOC:TermGenie, PMID:25535363]"}
{"concept_id": "C3895340", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cytokinin oxidase activity"}
{"concept_id": "C3895341", "aliases": ["down regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity", "down-regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity", "negative regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity", "downregulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity", "downregulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity", "downregulation of cytokinin dehydrogenase activity", "down-regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity", "negative regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity", "down regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity", "down regulation of cytokinin dehydrogenase activity", "downregulation of N6-dimethylallyladenine:acceptor oxidoreductase activity", "down-regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity", "down-regulation of cytokinin dehydrogenase activity", "negative regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity", "down regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity"], "types": ["T044"], "canonical_name": "negative regulation of cytokinin dehydrogenase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinin dehydrogenase activity. [GO_REF:0000059, GOC:TermGenie, PMID:25535363]"}
{"concept_id": "C3895342", "aliases": ["down-regulation of cytokinin oxidase activity", "downregulation of cytokinin oxidase activity"], "types": ["T044"], "canonical_name": "down regulation of cytokinin oxidase activity"}
{"concept_id": "C3895343", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 6-N-dimethylallyladenine:acceptor oxidoreductase activity"}
{"concept_id": "C3895344", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytokinin dehydrogenase activity"}
{"concept_id": "C3895345", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytokinin oxidase activity"}
{"concept_id": "C3895346", "aliases": ["inhibition of N6-dimethylallyladenine:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "inhibition of N6-dimethylallyladenine:(acceptor) oxidoreductase activity"}
{"concept_id": "C3895347", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cytokinin oxidase activity"}
{"concept_id": "C3895348", "aliases": ["protein localization in old growing cell tip", "protein localisation in old growing cell tip", "protein localisation to old growing cell tip"], "types": ["T043"], "canonical_name": "protein localization to old growing cell tip", "definition": "A process in which a protein is transported to, or maintained in, a location within an old growing cell tip. [GO_REF:0000087, GOC:TermGenie, PMID:17895368]"}
{"concept_id": "C3895349", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dendrite extension", "definition": "Any process that modulates the frequency, rate or extent of dendrite extension. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]"}
{"concept_id": "C3895350", "aliases": ["down regulation of dendrite extension", "inhibition of dendrite extension", "up regulation of dendrite retraction", "downregulation of dendrite extension", "down-regulation of dendrite extension", "up-regulation of dendrite retraction"], "types": ["T043"], "canonical_name": "negative regulation of dendrite extension", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dendrite extension. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]"}
{"concept_id": "C3895351", "aliases": ["up-regulation of dendrite extension", "up regulation of dendrite extension", "upregulation of dendrite extension", "activation of dendrite extension"], "types": ["T043"], "canonical_name": "positive regulation of dendrite extension", "definition": "Any process that activates or increases the frequency, rate or extent of dendrite extension. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]"}
{"concept_id": "C3895352", "aliases": ["up regulation of respiratory-chain phosphorylation", "up-regulation of oxidative phosphorylation", "upregulation of oxidative phosphorylation", "activation of oxidative phosphorylation", "positive regulation of respiratory-chain phosphorylation", "upregulation of respiratory-chain phosphorylation", "up-regulation of respiratory-chain phosphorylation", "up regulation of oxidative phosphorylation"], "types": ["T044"], "canonical_name": "positive regulation of oxidative phosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation. [GO_REF:0000058, GOC:TermGenie, PMID:10225962]"}
{"concept_id": "C3895353", "aliases": [], "types": ["T044"], "canonical_name": "activation of respiratory-chain phosphorylation"}
{"concept_id": "C3895354", "aliases": ["P granule formation", "polar granule assembly", "germline granule formation", "germline granule assembly", "polar granule formation"], "types": ["T045"], "canonical_name": "P granule assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a P granule. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836]"}
{"concept_id": "C3895355", "aliases": ["germline granule disassembly", "polar granule disassembly"], "types": ["T043"], "canonical_name": "P granule disassembly", "definition": "The disaggregation of a P granule into its constituent components. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836]"}
{"concept_id": "C3895356", "aliases": ["sigma factor antagonist complex location"], "types": ["T026"], "canonical_name": "sigma factor antagonist complex", "definition": "A protein complex which is capable of sigma factor antagonist activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23687042]"}
{"concept_id": "C3895357", "aliases": [], "types": ["T042"], "canonical_name": "palisade mesophyll development", "definition": "The process whose specific outcome is the progression of a palisade mesophyll over time, from its formation to the mature structure. [GO_REF:0000080, GOC:TermGenie, PMID:24663344]"}
{"concept_id": "C3895358", "aliases": [], "types": ["T042"], "canonical_name": "palisade parenchyma development"}
{"concept_id": "C3895359", "aliases": [], "types": ["T042"], "canonical_name": "extraembryonic membrane development", "definition": "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584]"}
{"concept_id": "C3895360", "aliases": ["regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity", "regulation of 5,10-CH2-H4folate reductase activity", "regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "regulation of methylenetetrahydrofolate reductase (NADPH2)", "regulation of 5,10-CH(2)-H(4)folate reductase activity", "regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity", "regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity", "regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity", "regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity", "regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity", "regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity", "regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "regulation of N5,N10-methylenetetrahydrofolate reductase activity", "regulation of N5,10-methylenetetrahydrofolate reductase activity"], "types": ["T044"], "canonical_name": "regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity", "definition": "Any process that modulates the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity. [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206]"}
{"concept_id": "C3895362", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"}
{"concept_id": "C3895363", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5,10-methylenetetrahydrofolate reductase activity"}
{"concept_id": "C3895364", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 5,10-methylenetetrahydrofolic acid reductase activity"}
{"concept_id": "C3895365", "aliases": [], "types": ["T044"], "canonical_name": "regulation of MetF"}
{"concept_id": "C3895366", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity"}
{"concept_id": "C3895367", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methylenetetrahydrofolate reductase [NAD(P)H]"}
{"concept_id": "C3895368", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methylenetetrahydrofolate reductase activity"}
{"concept_id": "C3895369", "aliases": [], "types": ["T044"], "canonical_name": "regulation of methylenetetrahydrofolic acid reductase activity"}
{"concept_id": "C3895370", "aliases": [], "types": ["T044"], "canonical_name": "regulation of MTHFR activity"}
{"concept_id": "C3895371", "aliases": [], "types": ["T044"], "canonical_name": "regulation of N(5),N(10)-methylenetetrahydrofolate reductase activity"}
{"concept_id": "C3895372", "aliases": [], "types": ["T044"], "canonical_name": "regulation of N(5,10)-methylenetetrahydrofolate reductase activity"}
{"concept_id": "C3895373", "aliases": ["downregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "down regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity", "negative regulation of 5,10-CH2-H4folate reductase activity", "down regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "down regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "down regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "downregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity", "downregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "negative regulation of N5,10-methylenetetrahydrofolate reductase activity", "downregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "downregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity", "downregulation of N5,N10-methylenetetrahydrofolate reductase activity", "down regulation of 5,10-CH(2)-H(4)folate reductase activity", "down regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity", "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity", "down-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity", "down regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "down regulation of 5,10-CH2-H4folate reductase activity", "downregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity", "down regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity", "down-regulation of N5,N10-methylenetetrahydrofolate reductase activity", "down regulation of N5,N10-methylenetetrahydrofolate reductase activity", "down-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "negative regulation of 5,10-CH(2)-H(4)folate reductase activity", "down-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity", "downregulation of N5,10-methylenetetrahydrofolate reductase activity", "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity", "down-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "down-regulation of 5,10-CH2-H4folate reductase activity", "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity", "negative regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity", "down-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity", "downregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "down regulation of N5,10-methylenetetrahydrofolate reductase activity", "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity", "downregulation of 5,10-CH2-H4folate reductase activity", "negative regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity", "down-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "downregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "down regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity", "downregulation of 5,10-CH(2)-H(4)folate reductase activity", "down-regulation of 5,10-CH(2)-H(4)folate reductase activity", "down regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "negative regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "negative regulation of methylenetetrahydrofolate reductase (NADPH2)", "down-regulation of methylenetetrahydrofolate reductase (NADPH2)", "down regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity", "downregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity", "negative regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "down-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "down-regulation of N5,10-methylenetetrahydrofolate reductase activity", "downregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "downregulation of methylenetetrahydrofolate reductase (NADPH2)", "downregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity", "down-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity", "down-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity", "down-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity", "negative regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "down regulation of methylenetetrahydrofolate reductase (NADPH2)", "negative regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity", "down-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity", "negative regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity", "negative regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "down regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity", "down-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity", "downregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity", "negative regulation of N5,N10-methylenetetrahydrofolate reductase activity", "negative regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity", "down regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity", "negative regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "negative regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity"], "types": ["T044"], "canonical_name": "negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity. [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206]"}
{"concept_id": "C3895375", "aliases": ["down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"], "types": ["T044"], "canonical_name": "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"}
{"concept_id": "C3895376", "aliases": ["down-regulation of MetF"], "types": ["T044"], "canonical_name": "down regulation of MetF"}
{"concept_id": "C3895377", "aliases": ["negative regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity", "downregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity", "down-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity"], "types": ["T044"], "canonical_name": "down regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity"}
{"concept_id": "C3895378", "aliases": ["down-regulation of methylenetetrahydrofolate reductase [NAD(P)H]", "negative regulation of methylenetetrahydrofolate reductase [NAD(P)H]", "downregulation of methylenetetrahydrofolate reductase [NAD(P)H]"], "types": ["T044"], "canonical_name": "down regulation of methylenetetrahydrofolate reductase [NAD(P)H]"}
{"concept_id": "C3895380", "aliases": ["negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"], "types": ["T044"], "canonical_name": "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"}
{"concept_id": "C3895381", "aliases": ["negative regulation of MetF"], "types": ["T044"], "canonical_name": "downregulation of MetF"}
{"concept_id": "C3895383", "aliases": ["inhibition of 5,10-CH2-H4folate reductase activity"], "types": ["T044"], "canonical_name": "inhibition of 5,10-CH(2)-H(4)folate reductase activity"}
{"concept_id": "C3895384", "aliases": ["inhibition of 5,10-methylenetetrahydrofolate reductase (FADH2) activity"], "types": ["T044"], "canonical_name": "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"}
{"concept_id": "C3895385", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH) activity"}
{"concept_id": "C3895386", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 5,10-methylenetetrahydrofolate reductase (NADPH) activity"}
{"concept_id": "C3895387", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 5,10-methylenetetrahydropteroylglutamate reductase activity"}
{"concept_id": "C3895388", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity"}
{"concept_id": "C3895389", "aliases": ["inhibition of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "inhibition of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "inhibition of 5-methyltetrahydrofolate:NAD oxidoreductase activity"}
{"concept_id": "C3895390", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity"}
{"concept_id": "C3895391", "aliases": ["inhibition of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "inhibition of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity"}
{"concept_id": "C3895392", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of MetF"}
{"concept_id": "C3895393", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity"}
{"concept_id": "C3895394", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity"}
{"concept_id": "C3895395", "aliases": ["inhibition of methylenetetrahydrofolate reductase [NAD(P)H]"], "types": ["T044"], "canonical_name": "inhibition of methylenetetrahydrofolate reductase (NAD(P)H) activity"}
{"concept_id": "C3895396", "aliases": ["inhibition of methylenetetrahydrofolate reductase (NADPH2)"], "types": ["T044"], "canonical_name": "inhibition of methylenetetrahydrofolate reductase (NADPH(2)) activity"}
{"concept_id": "C3895397", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of N5,10-methylenetetrahydrofolate reductase activity"}
{"concept_id": "C3895398", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of N5,N10-methylenetetrahydrofolate reductase activity"}
{"concept_id": "C3895399", "aliases": ["upregulation of 5,10-CH2-H4folate reductase activity", "up regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity", "up-regulation of methylenetetrahydrofolate reductase (NADPH2)", "positive regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity", "up regulation of methylenetetrahydrofolate reductase (NADPH2)", "up-regulation of N5,10-methylenetetrahydrofolate reductase activity", "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity", "up-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity", "up regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity", "positive regulation of 5,10-CH2-H4folate reductase activity", "up regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "up-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity", "up regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity", "up-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "up regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "positive regulation of methylenetetrahydrofolate reductase (NADPH2)", "positive regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "upregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "up-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity", "upregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity", "up regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity", "up-regulation of 5,10-CH2-H4folate reductase activity", "upregulation of methylenetetrahydrofolate reductase (NADPH2)", "upregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "up regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "upregulation of 5,10-CH(2)-H(4)folate reductase activity", "upregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity", "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity", "up-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "positive regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity", "up-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity", "up regulation of 5,10-CH2-H4folate reductase activity", "positive regulation of 5,10-CH(2)-H(4)folate reductase activity", "positive regulation of N5,10-methylenetetrahydrofolate reductase activity", "positive regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity", "positive regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "up regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity", "up regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity", "up-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "up regulation of N5,10-methylenetetrahydrofolate reductase activity", "up regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "positive regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "up-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity", "up regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "positive regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity", "positive regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity", "up-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity", "up-regulation of N5,N10-methylenetetrahydrofolate reductase activity", "upregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "up regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity", "up regulation of 5,10-CH(2)-H(4)folate reductase activity", "upregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "upregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity", "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity", "up-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity", "up-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity", "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity", "upregulation of N5,N10-methylenetetrahydrofolate reductase activity", "upregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity", "positive regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity", "positive regulation of N5,N10-methylenetetrahydrofolate reductase activity", "up-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "upregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity", "upregulation of N5,10-methylenetetrahydrofolate reductase activity", "positive regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity", "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity", "up regulation of N5,N10-methylenetetrahydrofolate reductase activity", "upregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity", "upregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity", "upregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity", "up-regulation of 5,10-CH(2)-H(4)folate reductase activity", "positive regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity"], "types": ["T044"], "canonical_name": "positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity", "definition": "Any process that activates or increases the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity. [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206]"}
{"concept_id": "C3895401", "aliases": ["activation of 5,10-CH2-H4folate reductase activity"], "types": ["T044"], "canonical_name": "activation of 5,10-CH(2)-H(4)folate reductase activity"}
{"concept_id": "C3895402", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"}
{"concept_id": "C3895403", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5,10-methylenetetrahydrofolate reductase (FADH) activity"}
{"concept_id": "C3895404", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity"}
{"concept_id": "C3895405", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity"}
{"concept_id": "C3895406", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5,10-methylenetetrahydropteroylglutamate reductase activity"}
{"concept_id": "C3895407", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity"}
{"concept_id": "C3895408", "aliases": ["activation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity", "activation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "activation of 5-methyltetrahydrofolate:NAD oxidoreductase activity"}
{"concept_id": "C3895409", "aliases": [], "types": ["T044"], "canonical_name": "activation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity"}
{"concept_id": "C3895410", "aliases": ["activation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "activation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity"}
{"concept_id": "C3895411", "aliases": [], "types": ["T044"], "canonical_name": "activation of MetF"}
{"concept_id": "C3895412", "aliases": [], "types": ["T044"], "canonical_name": "activation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity"}
{"concept_id": "C3895413", "aliases": [], "types": ["T044"], "canonical_name": "activation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity"}
{"concept_id": "C3895414", "aliases": ["activation of methylenetetrahydrofolate reductase [NAD(P)H]"], "types": ["T044"], "canonical_name": "activation of methylenetetrahydrofolate reductase (NAD(P)H) activity"}
{"concept_id": "C3895415", "aliases": ["activation of methylenetetrahydrofolate reductase (NADPH2)"], "types": ["T044"], "canonical_name": "activation of methylenetetrahydrofolate reductase (NADPH(2)) activity"}
{"concept_id": "C3895416", "aliases": ["activation of N5,N10-methylenetetrahydrofolate reductase activity"], "types": ["T044"], "canonical_name": "activation of N5,10-methylenetetrahydrofolate reductase activity"}
{"concept_id": "C3895418", "aliases": ["upregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"], "types": ["T044"], "canonical_name": "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"}
{"concept_id": "C3895419", "aliases": ["up-regulation of MetF", "upregulation of MetF", "up regulation of MetF"], "types": ["T044"], "canonical_name": "positive regulation of MetF"}
{"concept_id": "C3895420", "aliases": ["up regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity", "up-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity", "upregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity"], "types": ["T044"], "canonical_name": "positive regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity"}
{"concept_id": "C3895421", "aliases": ["upregulation of methylenetetrahydrofolate reductase [NAD(P)H]", "up regulation of methylenetetrahydrofolate reductase [NAD(P)H]", "up-regulation of methylenetetrahydrofolate reductase [NAD(P)H]"], "types": ["T044"], "canonical_name": "positive regulation of methylenetetrahydrofolate reductase [NAD(P)H]"}
{"concept_id": "C3895422", "aliases": ["up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"], "types": ["T044"], "canonical_name": "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity"}
{"concept_id": "C3895423", "aliases": ["DNA recombinase mediator complex formation"], "types": ["T044"], "canonical_name": "DNA recombinase mediator complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a DNA recombinase mediator complex. [GO_REF:0000079, GOC:rb, GOC:TermGenie, PMID:18347097]"}
{"concept_id": "C3895424", "aliases": ["regulation of DNA recombinase mediator complex formation"], "types": ["T040"], "canonical_name": "regulation of DNA recombinase mediator complex assembly", "definition": "Any process that modulates the frequency, rate or extent of DNA recombinase mediator complex assembly. [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097]"}
{"concept_id": "C3895425", "aliases": ["negative regulation of DNA recombinase mediator complex formation", "down-regulation of DNA recombinase mediator complex formation", "down regulation of DNA recombinase mediator complex assembly", "down regulation of DNA recombinase mediator complex formation", "down-regulation of DNA recombinase mediator complex assembly", "downregulation of DNA recombinase mediator complex formation", "downregulation of DNA recombinase mediator complex assembly"], "types": ["T043"], "canonical_name": "negative regulation of DNA recombinase mediator complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombinase mediator complex assembly. [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097]"}
{"concept_id": "C3895426", "aliases": ["inhibition of DNA recombinase mediator complex formation"], "types": ["T043"], "canonical_name": "inhibition of DNA recombinase mediator complex assembly"}
{"concept_id": "C3895427", "aliases": ["iron(2+) transmembrane transport"], "types": ["T044"], "canonical_name": "ferrous iron transmembrane transport"}
{"concept_id": "C3895428", "aliases": [], "types": ["T044"], "canonical_name": "corticosterone binding", "definition": "Binding to corticosterone. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]"}
{"concept_id": "C3895429", "aliases": [], "types": ["T044"], "canonical_name": "11-deoxycortisol binding", "definition": "Binding to 11-deoxycortisol. [GO_REF:0000067, GOC:TermGenie, PMID:10802282]"}
{"concept_id": "C3895430", "aliases": [], "types": ["T044"], "canonical_name": "21-deoxycortisol binding", "definition": "Binding to 21-deoxycortisol. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]"}
{"concept_id": "C3895431", "aliases": [], "types": ["T044"], "canonical_name": "11-deoxycorticosterone binding", "definition": "Binding to 11-deoxycorticosterone. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]"}
{"concept_id": "C3895432", "aliases": [], "types": ["T044"], "canonical_name": "11beta-hydroxyprogesterone binding", "definition": "Binding to 11beta-hydroxyprogesterone. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]"}
{"concept_id": "C3895433", "aliases": [], "types": ["T044"], "canonical_name": "17alpha-hydroxyprogesterone binding", "definition": "Binding to 17alpha-hydroxyprogesterone. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]"}
{"concept_id": "C3895434", "aliases": ["regulation of IL-17-mediated signalling pathway", "regulation of interleukin-17-mediated signalling pathway", "regulation of IL-17-mediated signaling pathway"], "types": ["T044"], "canonical_name": "regulation of interleukin-17-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of interleukin-17-mediated signaling pathway. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]"}
{"concept_id": "C3895435", "aliases": ["down regulation of interleukin-17-mediated signaling pathway", "downregulation of interleukin-17-mediated signaling pathway", "negative regulation of IL-17-mediated signaling pathway", "negative regulation of IL-17-mediated signalling pathway", "down regulation of IL-17-mediated signaling pathway", "negative regulation of interleukin-17-mediated signalling pathway", "down-regulation of IL-17-mediated signaling pathway", "down-regulation of interleukin-17-mediated signaling pathway", "downregulation of IL-17-mediated signalling pathway", "down regulation of IL-17-mediated signalling pathway", "down-regulation of IL-17-mediated signalling pathway", "downregulation of interleukin-17-mediated signalling pathway", "down-regulation of interleukin-17-mediated signalling pathway", "downregulation of IL-17-mediated signaling pathway", "down regulation of interleukin-17-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of interleukin-17-mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17-mediated signaling pathway. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]"}
{"concept_id": "C3895436", "aliases": ["inhibition of IL-17-mediated signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of IL-17-mediated signaling pathway"}
{"concept_id": "C3895437", "aliases": ["inhibition of interleukin-17-mediated signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of interleukin-17-mediated signaling pathway"}
{"concept_id": "C3895438", "aliases": ["upregulation of IL-17-mediated signaling pathway", "activation of IL-17-mediated signalling pathway", "activation of IL-17-mediated signaling pathway", "up regulation of IL-17-mediated signaling pathway", "activation of interleukin-17-mediated signalling pathway", "upregulation of interleukin-17-mediated signaling pathway", "upregulation of interleukin-17-mediated signalling pathway", "up regulation of IL-17-mediated signalling pathway", "up-regulation of interleukin-17-mediated signaling pathway", "upregulation of IL-17-mediated signalling pathway", "positive regulation of IL-17-mediated signaling pathway", "positive regulation of IL-17-mediated signalling pathway", "up regulation of interleukin-17-mediated signalling pathway", "up regulation of interleukin-17-mediated signaling pathway", "up-regulation of IL-17-mediated signaling pathway", "up-regulation of interleukin-17-mediated signalling pathway", "up-regulation of IL-17-mediated signalling pathway", "positive regulation of interleukin-17-mediated signalling pathway", "activation of interleukin-17-mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of interleukin-17-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-17-mediated signaling pathway. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]"}
{"concept_id": "C3895439", "aliases": ["regulation of CCL-20 production", "regulation of CCL20 production", "regulation of C-C motif chemokine 20 production"], "types": ["T040"], "canonical_name": "regulation of chemokine (C-C motif) ligand 20 production", "definition": "Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 20 production. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]"}
{"concept_id": "C3895440", "aliases": ["downregulation of CCL-20 production", "down-regulation of chemokine (C-C motif) ligand 20 production", "downregulation of CCL20 production", "down regulation of CCL-20 production", "down regulation of CCL20 production", "down regulation of C-C motif chemokine 20 production", "down-regulation of CCL20 production", "down-regulation of CCL-20 production", "down-regulation of C-C motif chemokine 20 production", "downregulation of C-C motif chemokine 20 production", "negative regulation of C-C motif chemokine 20 production", "downregulation of chemokine (C-C motif) ligand 20 production", "negative regulation of CCL-20 production", "down regulation of chemokine (C-C motif) ligand 20 production", "negative regulation of CCL20 production"], "types": ["T040"], "canonical_name": "negative regulation of chemokine (C-C motif) ligand 20 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 20 production. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]"}
{"concept_id": "C3895441", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of C-C motif chemokine 20 production"}
{"concept_id": "C3895442", "aliases": ["inhibition of CCL20 production"], "types": ["T040"], "canonical_name": "inhibition of CCL-20 production"}
{"concept_id": "C3895443", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of chemokine (C-C motif) ligand 20 production"}
{"concept_id": "C3895444", "aliases": ["positive regulation of CCL-20 production", "upregulation of C-C motif chemokine 20 production", "upregulation of chemokine (C-C motif) ligand 20 production", "positive regulation of CCL20 production", "up-regulation of CCL-20 production", "up regulation of chemokine (C-C motif) ligand 20 production", "upregulation of CCL20 production", "up-regulation of chemokine (C-C motif) ligand 20 production", "up regulation of CCL-20 production", "positive regulation of C-C motif chemokine 20 production", "up regulation of CCL20 production", "up-regulation of C-C motif chemokine 20 production", "upregulation of CCL-20 production", "up-regulation of CCL20 production", "up regulation of C-C motif chemokine 20 production"], "types": ["T040"], "canonical_name": "positive regulation of chemokine (C-C motif) ligand 20 production", "definition": "Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]"}
{"concept_id": "C3895445", "aliases": [], "types": ["T040"], "canonical_name": "activation of C-C motif chemokine 20 production"}
{"concept_id": "C3895446", "aliases": ["activation of CCL20 production"], "types": ["T040"], "canonical_name": "activation of CCL-20 production"}
{"concept_id": "C3895447", "aliases": [], "types": ["T040"], "canonical_name": "activation of chemokine (C-C motif) ligand 20 production"}
{"concept_id": "C3895450", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plant epidermal cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of plant epidermal cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:123345]"}
{"concept_id": "C3895451", "aliases": ["down-regulation of plant epidermal cell differentiation", "downregulation of plant epidermal cell differentiation", "down regulation of plant epidermal cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of plant epidermal cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of plant epidermal cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:123345]"}
{"concept_id": "C3895452", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of plant epidermal cell differentiation"}
{"concept_id": "C3895453", "aliases": ["up regulation of plant epidermal cell differentiation", "up-regulation of plant epidermal cell differentiation", "upregulation of plant epidermal cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of plant epidermal cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of plant epidermal cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:123345]"}
{"concept_id": "C3895454", "aliases": [], "types": ["T043"], "canonical_name": "activation of plant epidermal cell differentiation"}
{"concept_id": "C3895455", "aliases": ["regulation of activating transcription factor 6 signaling in unfolded protein response", "regulation of UPR signaling by ATF6 stress sensor", "regulation of ATF6 branch of UPR", "regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling"], "types": ["T044"], "canonical_name": "regulation of ATF6-mediated unfolded protein response", "definition": "Any process that modulates the frequency, rate or extent of the ATF6-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]"}
{"concept_id": "C3895456", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ATF6 signal transduction pathway"}
{"concept_id": "C3895457", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ATF6 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895458", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ATF6-alpha UPR branch"}
{"concept_id": "C3895459", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ATF6-beta UPR branch"}
{"concept_id": "C3895460", "aliases": ["downregulation of activating transcription factor 6 signaling in unfolded protein response", "negative regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling", "down-regulation of activating transcription factor 6 signaling in unfolded protein response", "downregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling", "negative regulation of UPR signaling by ATF6 stress sensor", "down-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling", "downregulation of ATF6 branch of UPR", "down-regulation of UPR signaling by ATF6 stress sensor", "down regulation of ATF6-mediated unfolded protein response", "negative regulation of ATF6 branch of UPR", "down-regulation of ATF6-mediated unfolded protein response", "down-regulation of ATF6 branch of UPR", "downregulation of ATF6-mediated unfolded protein response", "down regulation of activating transcription factor 6 signaling in unfolded protein response", "negative regulation of activating transcription factor 6 signaling in unfolded protein response", "down regulation of UPR signaling by ATF6 stress sensor", "down regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling", "downregulation of UPR signaling by ATF6 stress sensor", "down regulation of ATF6 branch of UPR"], "types": ["T044"], "canonical_name": "negative regulation of ATF6-mediated unfolded protein response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the ATF6-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]"}
{"concept_id": "C3895461", "aliases": ["down-regulation of ATF6 signaling in response to endoplasmic reticulum stress", "negative regulation of ATF6 signaling in response to endoplasmic reticulum stress", "downregulation of ATF6 signaling in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "down regulation of ATF6 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895462", "aliases": ["down-regulation of ATF6-alpha UPR branch"], "types": ["T044"], "canonical_name": "down regulation of ATF6-alpha UPR branch"}
{"concept_id": "C3895463", "aliases": ["down-regulation of ATF6-beta UPR branch"], "types": ["T044"], "canonical_name": "down regulation of ATF6-beta UPR branch"}
{"concept_id": "C3895464", "aliases": ["negative regulation of ATF6-alpha UPR branch"], "types": ["T044"], "canonical_name": "downregulation of ATF6-alpha UPR branch"}
{"concept_id": "C3895465", "aliases": ["negative regulation of ATF6-beta UPR branch"], "types": ["T044"], "canonical_name": "downregulation of ATF6-beta UPR branch"}
{"concept_id": "C3895466", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of activating transcription factor 6 signaling in unfolded protein response"}
{"concept_id": "C3895467", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATF6 branch of UPR"}
{"concept_id": "C3895468", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATF6 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895469", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATF6-alpha UPR branch"}
{"concept_id": "C3895470", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATF6-beta UPR branch"}
{"concept_id": "C3895471", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATF6-mediated unfolded protein response"}
{"concept_id": "C3895472", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of endoplasmic reticulum unfolded protein response; ATF6 signaling"}
{"concept_id": "C3895473", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UPR signaling by ATF6 stress sensor"}
{"concept_id": "C3895474", "aliases": ["upregulation of UPR signaling by ATF6 stress sensor", "positive regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling", "up regulation of ATF6-mediated unfolded protein response", "positive regulation of UPR signaling by ATF6 stress sensor", "upregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling", "up regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling", "up regulation of ATF6 branch of UPR", "positive regulation of ATF6 branch of UPR", "upregulation of ATF6 branch of UPR", "up-regulation of ATF6-mediated unfolded protein response", "up regulation of UPR signaling by ATF6 stress sensor", "up-regulation of activating transcription factor 6 signaling in unfolded protein response", "up regulation of activating transcription factor 6 signaling in unfolded protein response", "upregulation of activating transcription factor 6 signaling in unfolded protein response", "up-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling", "up-regulation of UPR signaling by ATF6 stress sensor", "positive regulation of activating transcription factor 6 signaling in unfolded protein response", "upregulation of ATF6-mediated unfolded protein response", "up-regulation of ATF6 branch of UPR"], "types": ["T044"], "canonical_name": "positive regulation of ATF6-mediated unfolded protein response", "definition": "Any process that activates or increases the frequency, rate or extent of the ATF6-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]"}
{"concept_id": "C3895475", "aliases": [], "types": ["T044"], "canonical_name": "activation of activating transcription factor 6 signaling in unfolded protein response"}
{"concept_id": "C3895476", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATF6 branch of UPR"}
{"concept_id": "C3895477", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATF6 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895478", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATF6-alpha UPR branch"}
{"concept_id": "C3895479", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATF6-beta UPR branch"}
{"concept_id": "C3895480", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATF6-mediated unfolded protein response"}
{"concept_id": "C3895481", "aliases": [], "types": ["T044"], "canonical_name": "activation of endoplasmic reticulum unfolded protein response; ATF6 signaling"}
{"concept_id": "C3895482", "aliases": [], "types": ["T044"], "canonical_name": "activation of UPR signaling by ATF6 stress sensor"}
{"concept_id": "C3895483", "aliases": ["upregulation of ATF6 signaling in response to endoplasmic reticulum stress", "up regulation of ATF6 signaling in response to endoplasmic reticulum stress", "up-regulation of ATF6 signaling in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "positive regulation of ATF6 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895484", "aliases": ["upregulation of ATF6-alpha UPR branch"], "types": ["T044"], "canonical_name": "positive regulation of ATF6-alpha UPR branch"}
{"concept_id": "C3895485", "aliases": ["upregulation of ATF6-beta UPR branch"], "types": ["T044"], "canonical_name": "positive regulation of ATF6-beta UPR branch"}
{"concept_id": "C3895486", "aliases": ["up-regulation of ATF6-alpha UPR branch"], "types": ["T044"], "canonical_name": "up regulation of ATF6-alpha UPR branch"}
{"concept_id": "C3895487", "aliases": ["up-regulation of ATF6-beta UPR branch"], "types": ["T044"], "canonical_name": "up regulation of ATF6-beta UPR branch"}
{"concept_id": "C3895488", "aliases": ["regulation of UPR signaling by IRE1 stress sensor", "regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling", "regulation of IRE1 branch of UPR"], "types": ["T044"], "canonical_name": "regulation of IRE1-mediated unfolded protein response", "definition": "Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]"}
{"concept_id": "C3895489", "aliases": [], "types": ["T044"], "canonical_name": "regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction"}
{"concept_id": "C3895490", "aliases": [], "types": ["T044"], "canonical_name": "regulation of IRE1 signal transduction pathway"}
{"concept_id": "C3895491", "aliases": [], "types": ["T044"], "canonical_name": "regulation of IRE1 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895492", "aliases": [], "types": ["T044"], "canonical_name": "regulation of IRE1alpha unfolded protein response"}
{"concept_id": "C3895493", "aliases": [], "types": ["T044"], "canonical_name": "regulation of IRE1p unfolded protein response"}
{"concept_id": "C3895494", "aliases": ["down regulation of IRE1 branch of UPR", "down-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling", "downregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling", "down regulation of IRE1-mediated unfolded protein response", "down regulation of UPR signaling by IRE1 stress sensor", "down regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling", "negative regulation of IRE1 branch of UPR", "down-regulation of UPR signaling by IRE1 stress sensor", "downregulation of IRE1 branch of UPR", "negative regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling", "downregulation of IRE1-mediated unfolded protein response", "down-regulation of IRE1-mediated unfolded protein response", "negative regulation of UPR signaling by IRE1 stress sensor", "down-regulation of IRE1 branch of UPR", "downregulation of UPR signaling by IRE1 stress sensor"], "types": ["T044"], "canonical_name": "negative regulation of IRE1-mediated unfolded protein response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]"}
{"concept_id": "C3895495", "aliases": ["down-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction"], "types": ["T044"], "canonical_name": "down regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction"}
{"concept_id": "C3895496", "aliases": ["negative regulation of IRE1 signaling in response to endoplasmic reticulum stress", "downregulation of IRE1 signaling in response to endoplasmic reticulum stress", "down-regulation of IRE1 signaling in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "down regulation of IRE1 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895497", "aliases": ["down-regulation of IRE1alpha unfolded protein response", "downregulation of IRE1alpha unfolded protein response", "negative regulation of IRE1alpha unfolded protein response"], "types": ["T044"], "canonical_name": "down regulation of IRE1alpha unfolded protein response"}
{"concept_id": "C3895498", "aliases": ["downregulation of IRE1p unfolded protein response", "negative regulation of IRE1p unfolded protein response", "down-regulation of IRE1p unfolded protein response"], "types": ["T044"], "canonical_name": "down regulation of IRE1p unfolded protein response"}
{"concept_id": "C3895499", "aliases": ["negative regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction"], "types": ["T044"], "canonical_name": "downregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction"}
{"concept_id": "C3895500", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of endoplasmic reticulum unfolded protein response; IRE1 signaling"}
{"concept_id": "C3895501", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of inositol-requiring transmembrane kinase/endonuclease signal transduction"}
{"concept_id": "C3895502", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of IRE1 branch of UPR"}
{"concept_id": "C3895503", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of IRE1 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895504", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of IRE1-mediated unfolded protein response"}
{"concept_id": "C3895505", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of IRE1alpha unfolded protein response"}
{"concept_id": "C3895506", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of IRE1p unfolded protein response"}
{"concept_id": "C3895507", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UPR signaling by IRE1 stress sensor"}
{"concept_id": "C3895508", "aliases": ["upregulation of IRE1-mediated unfolded protein response", "upregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling", "upregulation of UPR signaling by IRE1 stress sensor", "up regulation of IRE1-mediated unfolded protein response", "positive regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling", "up-regulation of IRE1 branch of UPR", "up-regulation of IRE1-mediated unfolded protein response", "up-regulation of UPR signaling by IRE1 stress sensor", "up regulation of UPR signaling by IRE1 stress sensor", "up regulation of IRE1 branch of UPR", "positive regulation of IRE1 branch of UPR", "upregulation of IRE1 branch of UPR", "positive regulation of UPR signaling by IRE1 stress sensor", "up-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling", "up regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling"], "types": ["T044"], "canonical_name": "positive regulation of IRE1-mediated unfolded protein response", "definition": "Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]"}
{"concept_id": "C3895509", "aliases": [], "types": ["T044"], "canonical_name": "activation of endoplasmic reticulum unfolded protein response; IRE1 signaling"}
{"concept_id": "C3895510", "aliases": [], "types": ["T044"], "canonical_name": "activation of inositol-requiring transmembrane kinase/endonuclease signal transduction"}
{"concept_id": "C3895511", "aliases": [], "types": ["T044"], "canonical_name": "activation of IRE1 branch of UPR"}
{"concept_id": "C3895512", "aliases": [], "types": ["T044"], "canonical_name": "activation of IRE1 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895513", "aliases": [], "types": ["T044"], "canonical_name": "activation of IRE1-mediated unfolded protein response"}
{"concept_id": "C3895514", "aliases": [], "types": ["T044"], "canonical_name": "activation of IRE1alpha unfolded protein response"}
{"concept_id": "C3895515", "aliases": [], "types": ["T044"], "canonical_name": "activation of IRE1p unfolded protein response"}
{"concept_id": "C3895516", "aliases": [], "types": ["T044"], "canonical_name": "activation of UPR signaling by IRE1 stress sensor"}
{"concept_id": "C3895517", "aliases": ["upregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction"}
{"concept_id": "C3895518", "aliases": ["up-regulation of IRE1 signaling in response to endoplasmic reticulum stress", "up regulation of IRE1 signaling in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "positive regulation of IRE1 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895519", "aliases": ["up-regulation of IRE1alpha unfolded protein response", "upregulation of IRE1alpha unfolded protein response", "up regulation of IRE1alpha unfolded protein response"], "types": ["T044"], "canonical_name": "positive regulation of IRE1alpha unfolded protein response"}
{"concept_id": "C3895520", "aliases": ["up regulation of IRE1p unfolded protein response", "up-regulation of IRE1p unfolded protein response"], "types": ["T044"], "canonical_name": "positive regulation of IRE1p unfolded protein response"}
{"concept_id": "C3895521", "aliases": ["up-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction"], "types": ["T044"], "canonical_name": "up regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction"}
{"concept_id": "C3895522", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of IRE1 signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895523", "aliases": [], "types": ["T044"], "canonical_name": "upregulation of IRE1p unfolded protein response"}
{"concept_id": "C3895524", "aliases": ["regulation of UPR signaling by PERK stress sensor", "regulation of endoplasmic reticulum unfolded protein response; PERK signaling", "regulation of PKR-like ER kinase signal transduction", "regulation of PERK branch of UPR"], "types": ["T044"], "canonical_name": "regulation of PERK-mediated unfolded protein response", "definition": "Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]"}
{"concept_id": "C3895525", "aliases": [], "types": ["T044"], "canonical_name": "regulation of PERK signal transduction pathway"}
{"concept_id": "C3895526", "aliases": [], "types": ["T044"], "canonical_name": "regulation of PERK signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895527", "aliases": ["downregulation of PERK branch of UPR", "down-regulation of endoplasmic reticulum unfolded protein response; PERK signaling", "negative regulation of PKR-like ER kinase signal transduction", "down-regulation of UPR signaling by PERK stress sensor", "down regulation of UPR signaling by PERK stress sensor", "downregulation of endoplasmic reticulum unfolded protein response; PERK signaling", "down regulation of PERK branch of UPR", "negative regulation of UPR signaling by PERK stress sensor", "downregulation of PKR-like ER kinase signal transduction", "down regulation of PERK-mediated unfolded protein response", "down regulation of endoplasmic reticulum unfolded protein response; PERK signaling", "down-regulation of PERK branch of UPR", "down-regulation of PKR-like ER kinase signal transduction", "down-regulation of PERK-mediated unfolded protein response", "downregulation of PERK-mediated unfolded protein response", "down regulation of PKR-like ER kinase signal transduction", "negative regulation of endoplasmic reticulum unfolded protein response; PERK signaling", "downregulation of UPR signaling by PERK stress sensor", "negative regulation of PERK branch of UPR"], "types": ["T044"], "canonical_name": "negative regulation of PERK-mediated unfolded protein response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]"}
{"concept_id": "C3895528", "aliases": ["down-regulation of PERK signaling in response to endoplasmic reticulum stress", "downregulation of PERK signaling in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "down regulation of PERK signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895529", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of endoplasmic reticulum unfolded protein response; PERK signaling"}
{"concept_id": "C3895530", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of PERK branch of UPR"}
{"concept_id": "C3895531", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of PERK signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895532", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of PERK-mediated unfolded protein response"}
{"concept_id": "C3895533", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of PKR-like ER kinase signal transduction"}
{"concept_id": "C3895534", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UPR signaling by PERK stress sensor"}
{"concept_id": "C3895535", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of PERK signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895536", "aliases": ["up-regulation of UPR signaling by PERK stress sensor", "positive regulation of UPR signaling by PERK stress sensor", "upregulation of PERK-mediated unfolded protein response", "positive regulation of endoplasmic reticulum unfolded protein response; PERK signaling", "up regulation of PERK-mediated unfolded protein response", "upregulation of PKR-like ER kinase signal transduction", "upregulation of UPR signaling by PERK stress sensor", "upregulation of PERK branch of UPR", "upregulation of endoplasmic reticulum unfolded protein response; PERK signaling", "positive regulation of PKR-like ER kinase signal transduction", "up regulation of PERK branch of UPR", "up-regulation of PERK branch of UPR", "up regulation of endoplasmic reticulum unfolded protein response; PERK signaling", "up-regulation of endoplasmic reticulum unfolded protein response; PERK signaling", "positive regulation of PERK branch of UPR", "up regulation of UPR signaling by PERK stress sensor", "up-regulation of PKR-like ER kinase signal transduction", "up-regulation of PERK-mediated unfolded protein response", "up regulation of PKR-like ER kinase signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of PERK-mediated unfolded protein response", "definition": "Any process that activates or increases the frequency, rate or extent of the PERK-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]"}
{"concept_id": "C3895537", "aliases": [], "types": ["T044"], "canonical_name": "activation of endoplasmic reticulum unfolded protein response; PERK signaling"}
{"concept_id": "C3895538", "aliases": [], "types": ["T044"], "canonical_name": "activation of PERK branch of UPR"}
{"concept_id": "C3895539", "aliases": [], "types": ["T044"], "canonical_name": "activation of PERK signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895540", "aliases": [], "types": ["T044"], "canonical_name": "activation of PERK-mediated unfolded protein response"}
{"concept_id": "C3895541", "aliases": [], "types": ["T044"], "canonical_name": "activation of PKR-like ER kinase signal transduction"}
{"concept_id": "C3895542", "aliases": [], "types": ["T044"], "canonical_name": "activation of UPR signaling by PERK stress sensor"}
{"concept_id": "C3895543", "aliases": ["up-regulation of PERK signaling in response to endoplasmic reticulum stress", "up regulation of PERK signaling in response to endoplasmic reticulum stress", "upregulation of PERK signaling in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "positive regulation of PERK signaling in response to endoplasmic reticulum stress"}
{"concept_id": "C3895544", "aliases": [], "types": ["T038"], "canonical_name": "regulation of lytic viral life cycle"}
{"concept_id": "C3895545", "aliases": [], "types": ["T038"], "canonical_name": "regulation of viral assembly, maturation, egress, and release"}
{"concept_id": "C3895546", "aliases": [], "types": ["T038"], "canonical_name": "regulation of viral infectious cycle"}
{"concept_id": "C3895547", "aliases": [], "types": ["T038"], "canonical_name": "regulation of viral replication"}
{"concept_id": "C3895548", "aliases": ["down-regulation of lytic viral life cycle"], "types": ["T038"], "canonical_name": "down regulation of lytic viral life cycle"}
{"concept_id": "C3895549", "aliases": ["down-regulation of viral assembly, maturation, egress, and release"], "types": ["T038"], "canonical_name": "down regulation of viral assembly, maturation, egress, and release"}
{"concept_id": "C3895550", "aliases": ["down-regulation of viral infectious cycle", "downregulation of viral infectious cycle", "negative regulation of viral infectious cycle"], "types": ["T038"], "canonical_name": "down regulation of viral infectious cycle"}
{"concept_id": "C3895551", "aliases": ["negative regulation of viral replication", "down-regulation of viral replication", "downregulation of viral replication"], "types": ["T038"], "canonical_name": "down regulation of viral replication"}
{"concept_id": "C3895552", "aliases": ["negative regulation of lytic viral life cycle"], "types": ["T038"], "canonical_name": "downregulation of lytic viral life cycle"}
{"concept_id": "C3895553", "aliases": ["negative regulation of viral assembly, maturation, egress, and release"], "types": ["T038"], "canonical_name": "downregulation of viral assembly, maturation, egress, and release"}
{"concept_id": "C3895554", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of lytic viral life cycle"}
{"concept_id": "C3895555", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of viral assembly, maturation, egress, and release"}
{"concept_id": "C3895556", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of viral infectious cycle"}
{"concept_id": "C3895557", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of viral replication"}
{"concept_id": "C3895558", "aliases": [], "types": ["T038"], "canonical_name": "activation of lytic viral life cycle"}
{"concept_id": "C3895559", "aliases": [], "types": ["T038"], "canonical_name": "activation of viral assembly, maturation, egress, and release"}
{"concept_id": "C3895560", "aliases": [], "types": ["T038"], "canonical_name": "activation of viral infectious cycle"}
{"concept_id": "C3895561", "aliases": [], "types": ["T038"], "canonical_name": "activation of viral replication"}
{"concept_id": "C3895562", "aliases": ["up-regulation of lytic viral life cycle", "upregulation of lytic viral life cycle", "up regulation of lytic viral life cycle"], "types": ["T038"], "canonical_name": "positive regulation of lytic viral life cycle"}
{"concept_id": "C3895563", "aliases": ["up regulation of viral assembly, maturation, egress, and release", "upregulation of viral assembly, maturation, egress, and release", "up-regulation of viral assembly, maturation, egress, and release"], "types": ["T038"], "canonical_name": "positive regulation of viral assembly, maturation, egress, and release"}
{"concept_id": "C3895564", "aliases": ["up-regulation of viral infectious cycle", "upregulation of viral infectious cycle", "up regulation of viral infectious cycle"], "types": ["T038"], "canonical_name": "positive regulation of viral infectious cycle"}
{"concept_id": "C3895565", "aliases": ["upregulation of viral replication", "up regulation of viral replication", "up-regulation of viral replication"], "types": ["T038"], "canonical_name": "positive regulation of viral replication"}
{"concept_id": "C3895566", "aliases": ["regulation of T cell polarization", "regulation of T-cell polarization", "regulation of T lymphocyte polarization", "regulation of establishment of T-lymphocyte polarity", "regulation of establishment of T-cell polarity", "regulation of establishment of T lymphocyte polarity"], "types": ["T043"], "canonical_name": "regulation of establishment of T cell polarity", "definition": "Any process that modulates the frequency, rate or extent of establishment of T cell polarity. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895567", "aliases": ["negative regulation of T cell polarization", "down-regulation of establishment of T-cell polarity", "down-regulation of establishment of T-lymphocyte polarity", "negative regulation of establishment of T-cell polarity", "negative regulation of establishment of T lymphocyte polarity", "down regulation of establishment of T cell polarity", "down regulation of establishment of T-lymphocyte polarity", "negative regulation of T-cell polarization", "down regulation of T-cell polarization", "down regulation of establishment of T-cell polarity", "downregulation of T lymphocyte polarization", "downregulation of establishment of T-cell polarity", "downregulation of establishment of T lymphocyte polarity", "down-regulation of establishment of T lymphocyte polarity", "downregulation of establishment of T cell polarity", "negative regulation of establishment of T-lymphocyte polarity", "down regulation of T cell polarization", "down regulation of T lymphocyte polarization", "downregulation of T cell polarization", "down-regulation of T lymphocyte polarization", "down regulation of establishment of T lymphocyte polarity", "downregulation of T-cell polarization", "down-regulation of establishment of T cell polarity", "down-regulation of T cell polarization", "negative regulation of T lymphocyte polarization", "down-regulation of T-cell polarization", "downregulation of establishment of T-lymphocyte polarity"], "types": ["T043"], "canonical_name": "negative regulation of establishment of T cell polarity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895568", "aliases": ["inhibition of T-cell polarization", "inhibition of establishment of T lymphocyte polarity", "inhibition of establishment of T-lymphocyte polarity", "inhibition of T lymphocyte polarization", "inhibition of establishment of T-cell polarity", "inhibition of establishment of T cell polarity"], "types": ["T043"], "canonical_name": "inhibition of T cell polarization"}
{"concept_id": "C3895569", "aliases": ["up regulation of T cell polarization", "up-regulation of establishment of T-lymphocyte polarity", "up regulation of establishment of T-lymphocyte polarity", "upregulation of establishment of T-cell polarity", "upregulation of establishment of T lymphocyte polarity", "up regulation of establishment of T cell polarity", "upregulation of establishment of T-lymphocyte polarity", "positive regulation of T lymphocyte polarization", "up regulation of establishment of T-cell polarity", "positive regulation of establishment of T-lymphocyte polarity", "up-regulation of T cell polarization", "up regulation of establishment of T lymphocyte polarity", "up-regulation of establishment of T cell polarity", "up-regulation of T-cell polarization", "up-regulation of T lymphocyte polarization", "up regulation of T-cell polarization", "upregulation of T cell polarization", "up-regulation of establishment of T lymphocyte polarity", "up regulation of T lymphocyte polarization", "upregulation of establishment of T cell polarity", "positive regulation of establishment of T-cell polarity", "positive regulation of T-cell polarization", "upregulation of T lymphocyte polarization", "up-regulation of establishment of T-cell polarity", "upregulation of T-cell polarization", "positive regulation of establishment of T lymphocyte polarity", "positive regulation of T cell polarization"], "types": ["T043"], "canonical_name": "positive regulation of establishment of T cell polarity", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895570", "aliases": ["activation of T lymphocyte polarization", "activation of establishment of T-lymphocyte polarity", "activation of T-cell polarization", "activation of establishment of T cell polarity", "activation of establishment of T lymphocyte polarity", "activation of establishment of T-cell polarity"], "types": ["T043"], "canonical_name": "activation of T cell polarization"}
{"concept_id": "C3895571", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plasma membrane raft polarization", "definition": "Any process that modulates the frequency, rate or extent of plasma membrane raft polarization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895572", "aliases": ["downregulation of plasma membrane raft polarization", "down regulation of plasma membrane raft polarization", "down-regulation of plasma membrane raft polarization"], "types": ["T043"], "canonical_name": "negative regulation of plasma membrane raft polarization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane raft polarization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895573", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of plasma membrane raft polarization"}
{"concept_id": "C3895574", "aliases": ["upregulation of plasma membrane raft polarization", "up-regulation of plasma membrane raft polarization", "up regulation of plasma membrane raft polarization"], "types": ["T043"], "canonical_name": "positive regulation of plasma membrane raft polarization", "definition": "Any process that activates or increases the frequency, rate or extent of plasma membrane raft polarization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895575", "aliases": [], "types": ["T043"], "canonical_name": "activation of plasma membrane raft polarization"}
{"concept_id": "C3895576", "aliases": [], "types": ["T043"], "canonical_name": "regulation of receptor clustering", "definition": "Any process that modulates the frequency, rate or extent of receptor clustering. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895577", "aliases": ["down regulation of receptor clustering", "downregulation of receptor clustering", "down-regulation of receptor clustering"], "types": ["T043"], "canonical_name": "negative regulation of receptor clustering", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of receptor clustering. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895578", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of receptor clustering"}
{"concept_id": "C3895579", "aliases": ["up regulation of receptor clustering", "upregulation of receptor clustering", "up-regulation of receptor clustering"], "types": ["T043"], "canonical_name": "positive regulation of receptor clustering", "definition": "Any process that activates or increases the frequency, rate or extent of receptor clustering. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895580", "aliases": [], "types": ["T043"], "canonical_name": "activation of receptor clustering"}
{"concept_id": "C3895581", "aliases": ["down regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress", "down regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress", "negative regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress", "downregulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress", "down regulation of eiF2alpha phosphorylation in response to ER stress", "negative regulation of eiF2alpha phosphorylation in response to ER stress", "downregulation of eiF2alpha phosphorylation in response to ER stress", "down-regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress", "down-regulation of eiF2alpha phosphorylation in response to ER stress", "downregulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress", "negative regulation of ER stress-induced eIF2 alpha phosphorylation", "negative regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress", "down-regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16835242]"}
{"concept_id": "C3895582", "aliases": ["inhibition of eiF2alpha phosphorylation in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "inhibition of eiF2alpha phosphorylation in response to ER stress"}
{"concept_id": "C3895583", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress"}
{"concept_id": "C3895584", "aliases": ["regulation of viral envelope fusion with host cell membrane", "regulation of viral envelope fusion with host membrane", "regulation of viral envelope fusion with host plasma membrane", "regulation of viral penetration via membrane fusion"], "types": ["T043"], "canonical_name": "regulation of fusion of virus membrane with host plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of fusion of virus membrane with host plasma membrane. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895585", "aliases": [], "types": ["T043"], "canonical_name": "regulation of viral entry into host cell via membrane fusion with the plasma membrane"}
{"concept_id": "C3895586", "aliases": [], "types": ["T043"], "canonical_name": "regulation of viral envelope fusion"}
{"concept_id": "C3895587", "aliases": [], "types": ["T044"], "canonical_name": "regulation of viral-cell fusion molecule activity"}
{"concept_id": "C3895588", "aliases": ["downregulation of viral envelope fusion with host membrane", "down regulation of fusion of virus membrane with host plasma membrane", "downregulation of viral envelope fusion with host plasma membrane", "down-regulation of viral envelope fusion with host plasma membrane", "down regulation of viral envelope fusion with host plasma membrane", "down-regulation of viral envelope fusion with host cell membrane", "down regulation of viral envelope fusion with host cell membrane", "downregulation of viral envelope fusion with host cell membrane", "down regulation of viral envelope fusion with host membrane", "down-regulation of viral envelope fusion with host membrane", "downregulation of viral penetration via membrane fusion", "negative regulation of viral penetration via membrane fusion", "negative regulation of viral envelope fusion with host cell membrane", "down regulation of viral penetration via membrane fusion", "negative regulation of viral envelope fusion with host plasma membrane", "negative regulation of viral envelope fusion with host membrane", "downregulation of fusion of virus membrane with host plasma membrane", "down-regulation of fusion of virus membrane with host plasma membrane", "down-regulation of viral penetration via membrane fusion"], "types": ["T043"], "canonical_name": "negative regulation of fusion of virus membrane with host plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fusion of virus membrane with host plasma membrane. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895589", "aliases": ["negative regulation of viral entry into host cell via membrane fusion with the plasma membrane", "downregulation of viral entry into host cell via membrane fusion with the plasma membrane", "down-regulation of viral entry into host cell via membrane fusion with the plasma membrane"], "types": ["T043"], "canonical_name": "down regulation of viral entry into host cell via membrane fusion with the plasma membrane"}
{"concept_id": "C3895590", "aliases": ["down-regulation of viral-cell fusion molecule activity"], "types": ["T043"], "canonical_name": "down regulation of viral-cell fusion molecule activity"}
{"concept_id": "C3895591", "aliases": ["negative regulation of viral-cell fusion molecule activity"], "types": ["T043"], "canonical_name": "downregulation of viral-cell fusion molecule activity"}
{"concept_id": "C3895592", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fusion of virus membrane with host plasma membrane"}
{"concept_id": "C3895593", "aliases": ["inhibition of viral penetration via membrane fusion"], "types": ["T043"], "canonical_name": "inhibition of viral entry into host cell via membrane fusion with the plasma membrane"}
{"concept_id": "C3895594", "aliases": ["inhibition of viral envelope fusion with host plasma membrane", "inhibition of viral envelope fusion with host membrane"], "types": ["T043"], "canonical_name": "inhibition of viral envelope fusion with host cell membrane"}
{"concept_id": "C3895595", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of viral-cell fusion molecule activity"}
{"concept_id": "C3895596", "aliases": ["up regulation of viral envelope fusion with host membrane", "upregulation of viral envelope fusion with host cell membrane", "up regulation of viral envelope fusion with host cell membrane", "upregulation of viral penetration via membrane fusion", "upregulation of viral envelope fusion with host plasma membrane", "up regulation of fusion of virus membrane with host plasma membrane", "up-regulation of viral envelope fusion with host cell membrane", "positive regulation of viral envelope fusion with host cell membrane", "up-regulation of viral envelope fusion with host plasma membrane", "upregulation of viral envelope fusion with host membrane", "upregulation of fusion of virus membrane with host plasma membrane", "up-regulation of viral penetration via membrane fusion", "positive regulation of viral envelope fusion with host membrane", "up regulation of viral penetration via membrane fusion", "up-regulation of fusion of virus membrane with host plasma membrane", "positive regulation of viral penetration via membrane fusion", "up-regulation of viral envelope fusion with host membrane", "positive regulation of viral envelope fusion with host plasma membrane", "up regulation of viral envelope fusion with host plasma membrane"], "types": ["T038"], "canonical_name": "positive regulation of fusion of virus membrane with host plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of fusion of virus membrane with host plasma membrane. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]"}
{"concept_id": "C3895597", "aliases": ["activation of viral envelope fusion with host plasma membrane", "activation of viral envelope fusion with host cell membrane", "activation of viral envelope fusion with host membrane"], "types": ["T038"], "canonical_name": "activation of fusion of virus membrane with host plasma membrane"}
{"concept_id": "C3895598", "aliases": ["activation of viral penetration via membrane fusion"], "types": ["T038"], "canonical_name": "activation of viral entry into host cell via membrane fusion with the plasma membrane"}
{"concept_id": "C3895599", "aliases": [], "types": ["T038"], "canonical_name": "activation of viral-cell fusion molecule activity"}
{"concept_id": "C3895600", "aliases": ["upregulation of viral entry into host cell via membrane fusion with the plasma membrane", "up regulation of viral entry into host cell via membrane fusion with the plasma membrane", "up-regulation of viral entry into host cell via membrane fusion with the plasma membrane"], "types": ["T038"], "canonical_name": "positive regulation of viral entry into host cell via membrane fusion with the plasma membrane"}
{"concept_id": "C3895601", "aliases": ["upregulation of viral-cell fusion molecule activity"], "types": ["T038"], "canonical_name": "positive regulation of viral-cell fusion molecule activity"}
{"concept_id": "C3895602", "aliases": ["up-regulation of viral-cell fusion molecule activity"], "types": ["T038"], "canonical_name": "up regulation of viral-cell fusion molecule activity"}
{"concept_id": "C3895603", "aliases": ["regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress", "regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress", "regulation of ER stress-induced eIF2 alpha dephosphorylation", "regulation of eIF2alpha dephosphorylation in response to ER stress"], "types": ["T044"], "canonical_name": "regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation", "definition": "Any process that modulates the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C3895604", "aliases": ["upregulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress", "up-regulation of eIF2alpha dephosphorylation in response to ER stress", "up-regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress", "positive regulation of ER stress-induced eIF2 alpha dephosphorylation", "upregulation of eIF2alpha dephosphorylation in response to ER stress", "up-regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress", "up regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress", "positive regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress", "up regulation of eIF2alpha dephosphorylation in response to ER stress", "up regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress", "positive regulation of eIF2alpha dephosphorylation in response to ER stress", "upregulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]"}
{"concept_id": "C3895605", "aliases": ["activation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress"], "types": ["T044"], "canonical_name": "activation of eIF2alpha dephosphorylation in response to ER stress"}
{"concept_id": "C3895606", "aliases": [], "types": ["T044"], "canonical_name": "activation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress"}
{"concept_id": "C3895607", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress"}
{"concept_id": "C3895608", "aliases": ["regulation of F-actin severing"], "types": ["T043"], "canonical_name": "regulation of actin filament severing", "definition": "Any process that modulates the frequency, rate or extent of actin filament severing. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]"}
{"concept_id": "C3895609", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament severing activity"}
{"concept_id": "C3895610", "aliases": [], "types": ["T043"], "canonical_name": "regulation of barbed-end actin capping/severing activity"}
{"concept_id": "C3895611", "aliases": ["down-regulation of actin filament severing", "down regulation of actin filament severing", "downregulation of F-actin severing", "downregulation of actin filament severing", "negative regulation of F-actin severing", "down-regulation of F-actin severing", "down regulation of F-actin severing"], "types": ["T043"], "canonical_name": "negative regulation of actin filament severing", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]"}
{"concept_id": "C3895612", "aliases": ["negative regulation of actin filament severing activity", "downregulation of actin filament severing activity", "down-regulation of actin filament severing activity"], "types": ["T043"], "canonical_name": "down regulation of actin filament severing activity"}
{"concept_id": "C3895613", "aliases": ["down-regulation of barbed-end actin capping/severing activity"], "types": ["T043"], "canonical_name": "down regulation of barbed-end actin capping/severing activity"}
{"concept_id": "C3895614", "aliases": ["negative regulation of barbed-end actin capping/severing activity"], "types": ["T043"], "canonical_name": "downregulation of barbed-end actin capping/severing activity"}
{"concept_id": "C3895615", "aliases": ["inhibition of actin filament severing"], "types": ["T043"], "canonical_name": "inhibition of F-actin severing"}
{"concept_id": "C3895616", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of actin filament severing activity"}
{"concept_id": "C3895617", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of barbed-end actin capping/severing activity"}
{"concept_id": "C3895618", "aliases": ["upregulation of actin filament severing", "positive regulation of F-actin severing", "upregulation of F-actin severing", "up regulation of F-actin severing", "up-regulation of F-actin severing", "up-regulation of actin filament severing", "up regulation of actin filament severing"], "types": ["T043"], "canonical_name": "positive regulation of actin filament severing", "definition": "Any process that activates or increases the frequency, rate or extent of actin filament severing. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]"}
{"concept_id": "C3895619", "aliases": ["activation of actin filament severing"], "types": ["T043"], "canonical_name": "activation of F-actin severing"}
{"concept_id": "C3895620", "aliases": [], "types": ["T043"], "canonical_name": "activation of actin filament severing activity"}
{"concept_id": "C3895621", "aliases": [], "types": ["T043"], "canonical_name": "activation of barbed-end actin capping/severing activity"}
{"concept_id": "C3895622", "aliases": ["up-regulation of actin filament severing activity", "upregulation of actin filament severing activity", "up regulation of actin filament severing activity"], "types": ["T043"], "canonical_name": "positive regulation of actin filament severing activity"}
{"concept_id": "C3895623", "aliases": ["upregulation of barbed-end actin capping/severing activity"], "types": ["T043"], "canonical_name": "positive regulation of barbed-end actin capping/severing activity"}
{"concept_id": "C3895624", "aliases": ["up-regulation of barbed-end actin capping/severing activity"], "types": ["T043"], "canonical_name": "up regulation of barbed-end actin capping/severing activity"}
{"concept_id": "C3895625", "aliases": ["regulation of peptidolysis during protein maturation in phagosome", "regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "regulation of peptidolysis during protein maturation in phagocytic vesicle", "regulation of protein maturation by peptide bond hydrolysis in phagosome", "regulation of protein maturation by peptide bond cleavage in phagosome", "regulation of protein maturation by peptide bond cleavage in phagocytic vesicle", "regulation of protein processing in phagosome"], "types": ["T044"], "canonical_name": "regulation of protein processing in phagocytic vesicle", "definition": "Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]"}
{"concept_id": "C3895627", "aliases": ["regulation of protein maturation by proteolysis in phagosome"], "types": ["T044"], "canonical_name": "regulation of protein maturation by proteolysis in phagocytic vesicle"}
{"concept_id": "C3895628", "aliases": ["downregulation of protein maturation by peptide bond cleavage in phagocytic vesicle", "down-regulation of protein processing in phagosome", "down-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle", "downregulation of protein processing in phagosome", "down regulation of protein processing in phagocytic vesicle", "downregulation of protein processing in phagocytic vesicle", "down-regulation of protein processing in phagocytic vesicle", "negative regulation of protein maturation by peptide bond hydrolysis in phagosome", "down regulation of protein maturation by peptide bond cleavage in phagocytic vesicle", "downregulation of protein maturation by peptide bond cleavage in phagosome", "negative regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "downregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "down-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "down regulation of protein maturation by peptide bond hydrolysis in phagosome", "down regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "negative regulation of protein maturation by peptide bond cleavage in phagocytic vesicle", "negative regulation of protein maturation by peptide bond cleavage in phagosome", "down regulation of protein processing in phagosome", "down-regulation of protein maturation by peptide bond hydrolysis in phagosome", "negative regulation of protein processing in phagosome", "down-regulation of protein maturation by peptide bond cleavage in phagosome", "down regulation of protein maturation by peptide bond cleavage in phagosome", "downregulation of protein maturation by peptide bond hydrolysis in phagosome"], "types": ["T044"], "canonical_name": "negative regulation of protein processing in phagocytic vesicle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]"}
{"concept_id": "C3895629", "aliases": ["down regulation of peptidolysis during protein maturation in phagosome", "down-regulation of peptidolysis during protein maturation in phagosome", "negative regulation of peptidolysis during protein maturation in phagosome", "downregulation of peptidolysis during protein maturation in phagosome", "down-regulation of peptidolysis during protein maturation in phagocytic vesicle", "negative regulation of peptidolysis during protein maturation in phagocytic vesicle", "downregulation of peptidolysis during protein maturation in phagocytic vesicle"], "types": ["T044"], "canonical_name": "down regulation of peptidolysis during protein maturation in phagocytic vesicle"}
{"concept_id": "C3895630", "aliases": ["down regulation of protein maturation by proteolysis in phagosome", "down-regulation of protein maturation by proteolysis in phagocytic vesicle", "downregulation of protein maturation by proteolysis in phagosome", "down-regulation of protein maturation by proteolysis in phagosome", "downregulation of protein maturation by proteolysis in phagocytic vesicle"], "types": ["T044"], "canonical_name": "down regulation of protein maturation by proteolysis in phagocytic vesicle"}
{"concept_id": "C3895631", "aliases": ["inhibition of peptidolysis during protein maturation in phagosome", "inhibition of protein maturation by peptide bond hydrolysis in phagosome", "inhibition of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "inhibition of protein maturation by peptide bond cleavage in phagosome", "inhibition of protein maturation by peptide bond cleavage in phagocytic vesicle"], "types": ["T044"], "canonical_name": "inhibition of peptidolysis during protein maturation in phagocytic vesicle"}
{"concept_id": "C3895632", "aliases": ["inhibition of protein maturation by proteolysis in phagosome"], "types": ["T045"], "canonical_name": "inhibition of protein maturation by proteolysis in phagocytic vesicle"}
{"concept_id": "C3895633", "aliases": ["inhibition of protein processing in phagosome"], "types": ["T045"], "canonical_name": "inhibition of protein processing in phagocytic vesicle"}
{"concept_id": "C3895634", "aliases": ["negative regulation of protein maturation by proteolysis in phagosome"], "types": ["T045"], "canonical_name": "negative regulation of protein maturation by proteolysis in phagocytic vesicle"}
{"concept_id": "C3895635", "aliases": ["upregulation of protein maturation by peptide bond cleavage in phagosome", "positive regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "upregulation of protein processing in phagocytic vesicle", "up regulation of protein processing in phagosome", "upregulation of protein maturation by peptide bond cleavage in phagocytic vesicle", "upregulation of protein maturation by peptide bond hydrolysis in phagosome", "up-regulation of protein processing in phagosome", "up regulation of protein processing in phagocytic vesicle", "up-regulation of protein maturation by peptide bond cleavage in phagosome", "positive regulation of protein maturation by peptide bond cleavage in phagocytic vesicle", "upregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "up regulation of protein maturation by peptide bond hydrolysis in phagosome", "up-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "positive regulation of protein maturation by peptide bond hydrolysis in phagosome", "up regulation of protein maturation by peptide bond cleavage in phagosome", "up regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "positive regulation of protein maturation by peptide bond cleavage in phagosome", "up-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle", "up-regulation of protein processing in phagocytic vesicle", "up regulation of protein maturation by peptide bond cleavage in phagocytic vesicle", "positive regulation of protein processing in phagosome", "upregulation of protein processing in phagosome", "up-regulation of protein maturation by peptide bond hydrolysis in phagosome"], "types": ["T045"], "canonical_name": "positive regulation of protein processing in phagocytic vesicle", "definition": "Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]"}
{"concept_id": "C3895636", "aliases": ["activation of protein maturation by peptide bond hydrolysis in phagosome", "activation of peptidolysis during protein maturation in phagosome", "activation of protein maturation by peptide bond hydrolysis in phagocytic vesicle", "activation of protein maturation by peptide bond cleavage in phagocytic vesicle", "activation of protein maturation by peptide bond cleavage in phagosome"], "types": ["T045"], "canonical_name": "activation of peptidolysis during protein maturation in phagocytic vesicle"}
{"concept_id": "C3895637", "aliases": ["activation of protein maturation by proteolysis in phagosome"], "types": ["T045"], "canonical_name": "activation of protein maturation by proteolysis in phagocytic vesicle"}
{"concept_id": "C3895638", "aliases": ["activation of protein processing in phagosome"], "types": ["T045"], "canonical_name": "activation of protein processing in phagocytic vesicle"}
{"concept_id": "C3895639", "aliases": ["upregulation of peptidolysis during protein maturation in phagosome", "up-regulation of peptidolysis during protein maturation in phagocytic vesicle", "up-regulation of peptidolysis during protein maturation in phagosome", "up regulation of peptidolysis during protein maturation in phagocytic vesicle", "upregulation of peptidolysis during protein maturation in phagocytic vesicle", "up regulation of peptidolysis during protein maturation in phagosome", "positive regulation of peptidolysis during protein maturation in phagosome"], "types": ["T045"], "canonical_name": "positive regulation of peptidolysis during protein maturation in phagocytic vesicle"}
{"concept_id": "C3895640", "aliases": ["upregulation of protein maturation by proteolysis in phagosome", "up regulation of protein maturation by proteolysis in phagocytic vesicle", "up regulation of protein maturation by proteolysis in phagosome", "up-regulation of protein maturation by proteolysis in phagosome", "positive regulation of protein maturation by proteolysis in phagosome", "up-regulation of protein maturation by proteolysis in phagocytic vesicle", "upregulation of protein maturation by proteolysis in phagocytic vesicle"], "types": ["T045"], "canonical_name": "positive regulation of protein maturation by proteolysis in phagocytic vesicle"}
{"concept_id": "C3895641", "aliases": [], "types": ["T044"], "canonical_name": "estradiol binding", "definition": "Binding to estradiol. [GO_REF:0000067, GOC:TermGenie, PMID:9048584]"}
{"concept_id": "C3895642", "aliases": [], "types": ["T043"], "canonical_name": "response to bisphenol A", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22957036]"}
{"concept_id": "C3895643", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to bisphenol A", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22957036]"}
{"concept_id": "C3895644", "aliases": [], "types": ["T043"], "canonical_name": "response to cyanide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21854848]"}
{"concept_id": "C3895645", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cyanide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21854848]"}
{"concept_id": "C3895646", "aliases": ["primitive palate development", "processus palatinus medianus development", "palatum primarium development", "primary palate process development"], "types": ["T039"], "canonical_name": "primary palate development", "definition": "The process whose specific outcome is the progression of a primary palate over time, from its formation to the mature structure. [GO_REF:0000094, GOC:mgi_curators, GOC:TermGenie, PMID:24644145, PMID:25504820]"}
{"concept_id": "C3895647", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pyrimidine-containing compound salvage", "definition": "Any process that modulates the frequency, rate or extent of pyrimidine-containing compound salvage. [GO_REF:0000058, GOC:TermGenie, PMID:23695302]"}
{"concept_id": "C3895648", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pyrimidine salvage"}
{"concept_id": "C3895649", "aliases": ["up-regulation of pyrimidine-containing compound salvage", "upregulation of pyrimidine-containing compound salvage", "up regulation of pyrimidine-containing compound salvage"], "types": ["T044"], "canonical_name": "positive regulation of pyrimidine-containing compound salvage", "definition": "Any process that activates or increases the frequency, rate or extent of pyrimidine-containing compound salvage. [GO_REF:0000058, GOC:TermGenie, PMID:23695302]"}
{"concept_id": "C3895650", "aliases": [], "types": ["T044"], "canonical_name": "activation of pyrimidine salvage"}
{"concept_id": "C3895651", "aliases": [], "types": ["T044"], "canonical_name": "activation of pyrimidine-containing compound salvage"}
{"concept_id": "C3895652", "aliases": ["up regulation of pyrimidine salvage", "up-regulation of pyrimidine salvage", "upregulation of pyrimidine salvage"], "types": ["T044"], "canonical_name": "positive regulation of pyrimidine salvage"}
{"concept_id": "C3895653", "aliases": [], "types": ["T044"], "canonical_name": "regulation of DNA primase activity", "definition": "Any process that modulates the frequency, rate or extent of DNA primase activity. [GO_REF:0000059, GOC:TermGenie, PMID:14766746]"}
{"concept_id": "C3895654", "aliases": ["down regulation of DNA primase activity", "down-regulation of DNA primase activity", "downregulation of DNA primase activity"], "types": ["T044"], "canonical_name": "negative regulation of DNA primase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA primase activity. [GO_REF:0000059, GOC:TermGenie, PMID:14766746]"}
{"concept_id": "C3895655", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA primase activity"}
{"concept_id": "C3895656", "aliases": ["up regulation of DNA primase activity", "upregulation of DNA primase activity", "up-regulation of DNA primase activity"], "types": ["T044"], "canonical_name": "positive regulation of DNA primase activity", "definition": "Any process that activates or increases the frequency, rate or extent of DNA primase activity. [GO_REF:0000059, GOC:TermGenie, PMID:14766746]"}
{"concept_id": "C3895657", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA primase activity"}
{"concept_id": "C3895658", "aliases": [], "types": ["T043"], "canonical_name": "response to sodium arsenite", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18674524]"}
{"concept_id": "C3895659", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to sodium arsenite", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18674524]"}
{"concept_id": "C3895660", "aliases": [], "types": ["T043"], "canonical_name": "response to acrylamide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16292499]"}
{"concept_id": "C3895661", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to acrylamide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16292499]"}
{"concept_id": "C3895662", "aliases": ["regulation of TORC2 signal transduction"], "types": ["T044"], "canonical_name": "regulation of TORC2 signaling", "definition": "Any process that modulates the frequency, rate or extent of TORC2 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:24247430]"}
{"concept_id": "C3895663", "aliases": ["downregulation of TORC2 signal transduction", "down-regulation of TORC2 signaling", "down-regulation of TORC2 signal transduction", "down regulation of TORC2 signaling", "downregulation of TORC2 signaling", "negative regulation of TORC2 signal transduction", "down regulation of TORC2 signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of TORC2 signaling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of TORC2 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:24247430]"}
{"concept_id": "C3895664", "aliases": ["inhibition of TORC2 signaling"], "types": ["T044"], "canonical_name": "inhibition of TORC2 signal transduction"}
{"concept_id": "C3895665", "aliases": ["downregulation of respiratory gaseous exchange", "down-regulation of respiratory gaseous exchange", "down regulation of respiratory gaseous exchange"], "types": ["T039"], "canonical_name": "negative regulation of respiratory gaseous exchange", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. [GO_REF:0000058, GOC:TermGenie, PMID:22819705]"}
{"concept_id": "C3895666", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of respiratory gaseous exchange"}
{"concept_id": "C3895667", "aliases": ["up regulation of respiratory gaseous exchange", "upregulation of respiratory gaseous exchange", "up-regulation of respiratory gaseous exchange"], "types": ["T039"], "canonical_name": "positive regulation of respiratory gaseous exchange", "definition": "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. [GO_REF:0000058, GOC:TermGenie, PMID:22819705]"}
{"concept_id": "C3895668", "aliases": [], "types": ["T039"], "canonical_name": "activation of respiratory gaseous exchange"}
{"concept_id": "C3895669", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hepatocyte apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:8649852]"}
{"concept_id": "C3895670", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hepatocyte apoptosis"}
{"concept_id": "C3895671", "aliases": ["down regulation of hepatocyte apoptotic process", "down-regulation of hepatocyte apoptotic process", "downregulation of hepatocyte apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of hepatocyte apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:8649852]"}
{"concept_id": "C3895672", "aliases": ["down-regulation of hepatocyte apoptosis"], "types": ["T043"], "canonical_name": "down regulation of hepatocyte apoptosis"}
{"concept_id": "C3895673", "aliases": [], "types": ["T043"], "canonical_name": "downregulation of hepatocyte apoptosis"}
{"concept_id": "C3895674", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hepatocyte apoptosis"}
{"concept_id": "C3895675", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hepatocyte apoptotic process"}
{"concept_id": "C3895676", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of hepatocyte apoptosis"}
{"concept_id": "C3895677", "aliases": ["upregulation of hepatocyte apoptotic process", "up-regulation of hepatocyte apoptotic process", "up regulation of hepatocyte apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of hepatocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:8649852]"}
{"concept_id": "C3895678", "aliases": [], "types": ["T043"], "canonical_name": "activation of hepatocyte apoptosis"}
{"concept_id": "C3895679", "aliases": [], "types": ["T043"], "canonical_name": "activation of hepatocyte apoptotic process"}
{"concept_id": "C3895680", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of hepatocyte apoptosis"}
{"concept_id": "C3895681", "aliases": ["up-regulation of hepatocyte apoptosis"], "types": ["T043"], "canonical_name": "up regulation of hepatocyte apoptosis"}
{"concept_id": "C3895682", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of hepatocyte apoptosis"}
{"concept_id": "C3895683", "aliases": ["downregulation of ventricular cardiac muscle cell action potential", "down-regulation of ventricular cardiac muscle cell action potential", "down regulation of ventricular cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "negative regulation of ventricular cardiac muscle cell action potential", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ventricular cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]"}
{"concept_id": "C3895684", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ventricular cardiac muscle cell action potential"}
{"concept_id": "C3895685", "aliases": ["upregulation of ventricular cardiac muscle cell action potential", "up-regulation of ventricular cardiac muscle cell action potential", "up regulation of ventricular cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "positive regulation of ventricular cardiac muscle cell action potential", "definition": "Any process that activates or increases the frequency, rate or extent of ventricular cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]"}
{"concept_id": "C3895686", "aliases": [], "types": ["T043"], "canonical_name": "activation of ventricular cardiac muscle cell action potential"}
{"concept_id": "C3895687", "aliases": ["down regulation of atrial cardiac muscle cell action potential", "down-regulation of atrial cardiac muscle cell action potential", "downregulation of atrial cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "negative regulation of atrial cardiac muscle cell action potential", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of atrial cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]"}
{"concept_id": "C3895688", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of atrial cardiac muscle cell action potential"}
{"concept_id": "C3895689", "aliases": ["up-regulation of atrial cardiac muscle cell action potential", "up regulation of atrial cardiac muscle cell action potential", "upregulation of atrial cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "positive regulation of atrial cardiac muscle cell action potential", "definition": "Any process that activates or increases the frequency, rate or extent of atrial cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]"}
{"concept_id": "C3895690", "aliases": [], "types": ["T043"], "canonical_name": "activation of atrial cardiac muscle cell action potential"}
{"concept_id": "C3895691", "aliases": ["downregulation of AV node cardiac muscle cell action potential", "negative regulation of atrioventricular node cardiac muscle cell action potential", "down-regulation of AV node cell action potential", "down-regulation of atrioventricular node cardiac muscle cell action potential", "negative regulation of AV node cardiac muscle cell action potential", "downregulation of AV node cell action potential", "down regulation of AV node cardiac muscle cell action potential", "downregulation of atrioventricular node cardiac muscle cell action potential", "down regulation of AV node cell action potential", "down regulation of atrioventricular node cardiac muscle cell action potential", "down-regulation of AV node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "negative regulation of AV node cell action potential", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]"}
{"concept_id": "C3895692", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of atrioventricular node cardiac muscle cell action potential"}
{"concept_id": "C3895693", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of AV node cardiac muscle cell action potential"}
{"concept_id": "C3895694", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of AV node cell action potential"}
{"concept_id": "C3895695", "aliases": ["upregulation of AV node cell action potential", "up regulation of atrioventricular node cardiac muscle cell action potential", "positive regulation of atrioventricular node cardiac muscle cell action potential", "positive regulation of AV node cardiac muscle cell action potential", "up regulation of AV node cell action potential", "upregulation of AV node cardiac muscle cell action potential", "up-regulation of atrioventricular node cardiac muscle cell action potential", "upregulation of atrioventricular node cardiac muscle cell action potential", "up-regulation of AV node cell action potential", "up-regulation of AV node cardiac muscle cell action potential", "up regulation of AV node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "positive regulation of AV node cell action potential", "definition": "Any process that activates or increases the frequency, rate or extent of AV node cell action potential. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]"}
{"concept_id": "C3895696", "aliases": [], "types": ["T043"], "canonical_name": "activation of atrioventricular node cardiac muscle cell action potential"}
{"concept_id": "C3895697", "aliases": [], "types": ["T043"], "canonical_name": "activation of AV node cardiac muscle cell action potential"}
{"concept_id": "C3895698", "aliases": [], "types": ["T043"], "canonical_name": "activation of AV node cell action potential"}
{"concept_id": "C3895699", "aliases": ["regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization"], "types": ["T043"], "canonical_name": "regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "definition": "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]"}
{"concept_id": "C3895700", "aliases": ["down regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization", "down regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "down-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization", "negative regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization", "downregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization", "down-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "downregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization"], "types": ["T044"], "canonical_name": "negative regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]"}
{"concept_id": "C3895701", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization"}
{"concept_id": "C3895702", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization"}
{"concept_id": "C3895703", "aliases": ["up regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "upregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization", "upregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "up-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "positive regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization", "up-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization", "up regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization"], "types": ["T038"], "canonical_name": "positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "definition": "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]"}
{"concept_id": "C3895704", "aliases": [], "types": ["T038"], "canonical_name": "activation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization"}
{"concept_id": "C3895705", "aliases": [], "types": ["T038"], "canonical_name": "activation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization"}
{"concept_id": "C3895706", "aliases": ["up regulation of protein targeting to mitochondrion", "upregulation of protein targeting to mitochondrion", "upregulation of protein import into mitochondrion", "up-regulation of protein targeting to mitochondria", "up regulation of protein-mitochondrial targeting", "up-regulation of protein targeting to mitochondrion", "up-regulation of protein-mitochondrial targeting", "positive regulation of protein-mitochondrial targeting", "upregulation of protein targeting to mitochondria", "up regulation of protein targeting to mitochondria", "upregulation of protein-mitochondrial targeting", "positive regulation of protein import into mitochondrion", "up regulation of protein import into mitochondrion", "up-regulation of protein import into mitochondrion", "positive regulation of protein targeting to mitochondria"], "types": ["T043"], "canonical_name": "positive regulation of protein targeting to mitochondrion", "definition": "Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24270810]"}
{"concept_id": "C3895707", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitochondrial protein import"}
{"concept_id": "C3895708", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitochondrial translocation"}
{"concept_id": "C3895709", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein import into mitochondrion"}
{"concept_id": "C3895710", "aliases": ["activation of protein targeting to mitochondrion"], "types": ["T043"], "canonical_name": "activation of protein targeting to mitochondria"}
{"concept_id": "C3895711", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein-mitochondrial targeting"}
{"concept_id": "C3895712", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial protein import"}
{"concept_id": "C3895713", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial translocation"}
{"concept_id": "C3895714", "aliases": ["up-regulation of mitochondrial protein import"], "types": ["T043"], "canonical_name": "up regulation of mitochondrial protein import"}
{"concept_id": "C3895715", "aliases": ["up-regulation of mitochondrial translocation"], "types": ["T043"], "canonical_name": "up regulation of mitochondrial translocation"}
{"concept_id": "C3895716", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of mitochondrial protein import"}
{"concept_id": "C3895717", "aliases": [], "types": ["T043"], "canonical_name": "upregulation of mitochondrial translocation"}
{"concept_id": "C3895720", "aliases": ["nitric-oxide synthase complex location"], "types": ["T026"], "canonical_name": "nitric-oxide synthase complex", "definition": "A protein complex which is capable of nitric-oxide synthase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:25417112]"}
{"concept_id": "C3895721", "aliases": ["iNOS-S100A8/A9 complex location", "iNOS-S100A8/A9 complex"], "types": ["T026"], "canonical_name": "iNOS-S100A8/A9 complex", "definition": "A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine. [GOC:bhm, PMID:25417112]"}
{"concept_id": "C3895722", "aliases": [], "types": ["T043"], "canonical_name": "regulation of anion transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of anion transmembrane transport. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3895723", "aliases": ["down regulation of anion transmembrane transport", "downregulation of anion transmembrane transport", "down-regulation of anion transmembrane transport"], "types": ["T043"], "canonical_name": "negative regulation of anion transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3895724", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of anion transmembrane transport"}
{"concept_id": "C3895725", "aliases": ["up regulation of anion transmembrane transport", "upregulation of anion transmembrane transport", "up-regulation of anion transmembrane transport"], "types": ["T043"], "canonical_name": "positive regulation of anion transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of anion transmembrane transport. [GO_REF:0000058, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C3895726", "aliases": [], "types": ["T043"], "canonical_name": "activation of anion transmembrane transport"}
{"concept_id": "C3895727", "aliases": ["arachidonic acid transporter activity"], "types": ["T044"], "canonical_name": "arachidonate transporter activity"}
{"concept_id": "C3895728", "aliases": ["arachidonic acid transport"], "types": ["T043"], "canonical_name": "arachidonate transport", "definition": "The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GO_REF:0000065, GOC:bhm, GOC:TermGenie, PMID:15642721]"}
{"concept_id": "C3895729", "aliases": ["monounsaturated fatty acid metabolism"], "types": ["T044"], "canonical_name": "monounsaturated fatty acid metabolic process", "definition": "The chemical reactions and pathways involving monounsaturated fatty acid. [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]"}
{"concept_id": "C3895730", "aliases": ["monounsaturated fatty acid catabolism", "monounsaturated fatty acid breakdown", "monounsaturated fatty acid degradation"], "types": ["T044"], "canonical_name": "monounsaturated fatty acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of monounsaturated fatty acid. [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]"}
{"concept_id": "C3895731", "aliases": ["monounsaturated fatty acid synthesis", "monounsaturated fatty acid anabolism", "monounsaturated fatty acid biosynthesis", "monounsaturated fatty acid formation"], "types": ["T044"], "canonical_name": "monounsaturated fatty acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid. [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]"}
{"concept_id": "C3895732", "aliases": [], "types": ["T043"], "canonical_name": "response to micafungin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16928959]"}
{"concept_id": "C3895733", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to micafungin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16928959]"}
{"concept_id": "C3895734", "aliases": ["regulation of response to macrophage colony-stimulating factor stimulus", "regulation of response to M-CSF"], "types": ["T038"], "canonical_name": "regulation of response to macrophage colony-stimulating factor", "definition": "Any process that modulates the frequency, rate or extent of response to macrophage colony-stimulating factor. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895735", "aliases": ["negative regulation of response to M-CSF", "down-regulation of response to macrophage colony-stimulating factor stimulus", "down regulation of response to macrophage colony-stimulating factor stimulus", "down regulation of response to macrophage colony-stimulating factor", "downregulation of response to macrophage colony-stimulating factor stimulus", "down-regulation of response to M-CSF", "downregulation of response to macrophage colony-stimulating factor", "negative regulation of response to macrophage colony-stimulating factor stimulus", "down-regulation of response to macrophage colony-stimulating factor", "downregulation of response to M-CSF", "down regulation of response to M-CSF"], "types": ["T038"], "canonical_name": "negative regulation of response to macrophage colony-stimulating factor", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to macrophage colony-stimulating factor. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895736", "aliases": ["inhibition of response to macrophage colony-stimulating factor stimulus", "inhibition of response to macrophage colony-stimulating factor"], "types": ["T038"], "canonical_name": "inhibition of response to M-CSF"}
{"concept_id": "C3895737", "aliases": ["positive regulation of response to macrophage colony-stimulating factor stimulus", "upregulation of response to macrophage colony-stimulating factor", "up regulation of response to macrophage colony-stimulating factor stimulus", "positive regulation of response to M-CSF", "up regulation of response to M-CSF", "up-regulation of response to M-CSF", "up-regulation of response to macrophage colony-stimulating factor", "up regulation of response to macrophage colony-stimulating factor", "upregulation of response to M-CSF", "up-regulation of response to macrophage colony-stimulating factor stimulus", "upregulation of response to macrophage colony-stimulating factor stimulus"], "types": ["T038"], "canonical_name": "positive regulation of response to macrophage colony-stimulating factor", "definition": "Any process that activates or increases the frequency, rate or extent of response to macrophage colony-stimulating factor. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895738", "aliases": ["activation of response to macrophage colony-stimulating factor", "activation of response to macrophage colony-stimulating factor stimulus"], "types": ["T038"], "canonical_name": "activation of response to M-CSF"}
{"concept_id": "C3895739", "aliases": ["regulation of cellular response to macrophage colony-stimulating factor", "regulation of cellular response to M-CSF stimulus"], "types": ["T043"], "canonical_name": "regulation of cellular response to macrophage colony-stimulating factor stimulus", "definition": "Any process that modulates the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895740", "aliases": ["down-regulation of cellular response to macrophage colony-stimulating factor", "downregulation of cellular response to M-CSF stimulus", "downregulation of cellular response to macrophage colony-stimulating factor", "down-regulation of cellular response to macrophage colony-stimulating factor stimulus", "down regulation of cellular response to M-CSF stimulus", "negative regulation of cellular response to macrophage colony-stimulating factor", "down regulation of cellular response to macrophage colony-stimulating factor stimulus", "down-regulation of cellular response to M-CSF stimulus", "down regulation of cellular response to macrophage colony-stimulating factor", "downregulation of cellular response to macrophage colony-stimulating factor stimulus", "negative regulation of cellular response to M-CSF stimulus"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to macrophage colony-stimulating factor stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895741", "aliases": ["inhibition of cellular response to macrophage colony-stimulating factor", "inhibition of cellular response to macrophage colony-stimulating factor stimulus"], "types": ["T043"], "canonical_name": "inhibition of cellular response to M-CSF stimulus"}
{"concept_id": "C3895742", "aliases": ["up-regulation of cellular response to macrophage colony-stimulating factor", "up regulation of cellular response to macrophage colony-stimulating factor stimulus", "up-regulation of cellular response to M-CSF stimulus", "up regulation of cellular response to macrophage colony-stimulating factor", "up-regulation of cellular response to macrophage colony-stimulating factor stimulus", "upregulation of cellular response to M-CSF stimulus", "up regulation of cellular response to M-CSF stimulus", "upregulation of cellular response to macrophage colony-stimulating factor", "positive regulation of cellular response to M-CSF stimulus", "upregulation of cellular response to macrophage colony-stimulating factor stimulus", "positive regulation of cellular response to macrophage colony-stimulating factor"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to macrophage colony-stimulating factor stimulus", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895743", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to M-CSF stimulus"}
{"concept_id": "C3895744", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to macrophage colony-stimulating factor"}
{"concept_id": "C3895745", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to macrophage colony-stimulating factor stimulus"}
{"concept_id": "C3895746", "aliases": ["regulation of glia cell migration"], "types": ["T038"], "canonical_name": "regulation of glial cell migration", "definition": "Any process that modulates the frequency, rate or extent of glial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895747", "aliases": ["down regulation of glia cell migration", "down-regulation of glial cell migration", "negative regulation of glia cell migration", "down-regulation of glia cell migration", "downregulation of glial cell migration", "down regulation of glial cell migration", "downregulation of glia cell migration"], "types": ["T039"], "canonical_name": "negative regulation of glial cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895748", "aliases": ["inhibition of glial cell migration"], "types": ["T039"], "canonical_name": "inhibition of glia cell migration"}
{"concept_id": "C3895749", "aliases": ["upregulation of glia cell migration", "up regulation of glia cell migration", "upregulation of glial cell migration", "up regulation of glial cell migration", "positive regulation of glia cell migration", "up-regulation of glia cell migration", "up-regulation of glial cell migration"], "types": ["T039"], "canonical_name": "positive regulation of glial cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of glial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895750", "aliases": ["activation of glial cell migration"], "types": ["T039"], "canonical_name": "activation of glia cell migration"}
{"concept_id": "C3895751", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microglial cell activation", "definition": "Any process that modulates the frequency, rate or extent of microglial cell activation. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895752", "aliases": ["down regulation of microglial cell activation", "down-regulation of microglial cell activation", "downregulation of microglial cell activation"], "types": ["T043"], "canonical_name": "negative regulation of microglial cell activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895753", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microglial cell activation"}
{"concept_id": "C3895754", "aliases": ["up-regulation of microglial cell activation", "up regulation of microglial cell activation", "upregulation of microglial cell activation"], "types": ["T043"], "canonical_name": "positive regulation of microglial cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of microglial cell activation. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C3895755", "aliases": [], "types": ["T043"], "canonical_name": "activation of microglial cell activation"}
{"concept_id": "C3895756", "aliases": ["downregulation of regulation of microvillus length", "down regulation of regulation of microvillus length", "down-regulation of regulation of microvillus length"], "types": ["T043"], "canonical_name": "negative regulation of microvillus length", "definition": "A process that decreases the length of a microvillus. [GOC:als, PMID:22114352]"}
{"concept_id": "C3895757", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of regulation of microvillus length"}
{"concept_id": "C3895758", "aliases": ["up-regulation of regulation of microvillus length", "up regulation of regulation of microvillus length", "upregulation of regulation of microvillus length"], "types": ["T043"], "canonical_name": "positive regulation of microvillus length", "definition": "A process that increases the length of a microvillus. [GOC:als, PMID:22114352]"}
{"concept_id": "C3895759", "aliases": [], "types": ["T043"], "canonical_name": "activation of regulation of microvillus length"}
{"concept_id": "C3895760", "aliases": ["positive regulation of TRAIL-activated extrinsic apoptotic signaling pathway", "positive regulation of TRAIL-induced apoptotic signaling pathway", "up regulation of TRAIL-induced apoptotic signaling pathway", "up regulation of TRAIL-activated apoptotic signaling pathway", "upregulation of TRAIL-activated extrinsic apoptotic signaling pathway", "up regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "up-regulation of TRAIL-activated apoptotic signaling pathway", "up-regulation of TRAIL-induced apoptotic signaling pathway", "up-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "upregulation of TRAIL-induced apoptotic signaling pathway", "positive regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "up regulation of TRAIL-activated extrinsic apoptotic signaling pathway", "upregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway", "upregulation of TRAIL-activated apoptotic signaling pathway", "up-regulation of TRAIL-activated extrinsic apoptotic signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of TRAIL-activated apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24939851]"}
{"concept_id": "C3895761", "aliases": [], "types": ["T044"], "canonical_name": "activation of TRAIL-activated apoptotic signaling pathway"}
{"concept_id": "C3895762", "aliases": [], "types": ["T044"], "canonical_name": "activation of TRAIL-activated extrinsic apoptotic signaling pathway"}
{"concept_id": "C3895763", "aliases": [], "types": ["T044"], "canonical_name": "activation of TRAIL-induced apoptotic signaling pathway"}
{"concept_id": "C3895764", "aliases": [], "types": ["T044"], "canonical_name": "activation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway"}
{"concept_id": "C3895765", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intestinal D-glucose absorption", "definition": "Any process that modulates the frequency, rate or extent of intestinal D-glucose absorption. [GO_REF:0000058, GOA:als, GOC:TermGenie, PMID:22114352]"}
{"concept_id": "C3895766", "aliases": ["iron(2+) export"], "types": ["T043"], "canonical_name": "ferrous iron export"}
{"concept_id": "C3895769", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ferrous ion import into cell"}
{"concept_id": "C3895771", "aliases": [], "types": ["T043"], "canonical_name": "activation of ferrous ion import into cell"}
{"concept_id": "C3895797", "aliases": [], "types": ["T043"], "canonical_name": "regulation of non-membrane spanning protein tyrosine kinase activity", "definition": "Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]"}
{"concept_id": "C3895798", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity"}
{"concept_id": "C3895799", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ATP:protein-tyrosine O-phosphotransferase activity"}
{"concept_id": "C3895800", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Bruton's tyrosine kinase activity"}
{"concept_id": "C3895801", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic protein tyrosine kinase activity"}
{"concept_id": "C3895802", "aliases": [], "types": ["T043"], "canonical_name": "regulation of focal adhesion kinase activity"}
{"concept_id": "C3895803", "aliases": [], "types": ["T043"], "canonical_name": "regulation of janus kinase 1 activity"}
{"concept_id": "C3895804", "aliases": [], "types": ["T043"], "canonical_name": "regulation of janus kinase 2 activity"}
{"concept_id": "C3895805", "aliases": [], "types": ["T043"], "canonical_name": "regulation of janus kinase 3 activity"}
{"concept_id": "C3895806", "aliases": [], "types": ["T043"], "canonical_name": "regulation of non-specific protein-tyrosine kinase activity"}
{"concept_id": "C3895807", "aliases": [], "types": ["T043"], "canonical_name": "regulation of p60c-src protein tyrosine kinase activity"}
{"concept_id": "C3895808", "aliases": ["down-regulation of non-membrane spanning protein tyrosine kinase activity", "downregulation of non-membrane spanning protein tyrosine kinase activity", "down regulation of non-membrane spanning protein tyrosine kinase activity"], "types": ["T043"], "canonical_name": "negative regulation of non-membrane spanning protein tyrosine kinase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]"}
{"concept_id": "C3895809", "aliases": ["down-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity", "downregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity", "negative regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity"], "types": ["T043"], "canonical_name": "down regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity"}
{"concept_id": "C3895810", "aliases": ["downregulation of Bruton's tyrosine kinase activity", "negative regulation of Bruton's tyrosine kinase activity", "down-regulation of Bruton's tyrosine kinase activity"], "types": ["T043"], "canonical_name": "down regulation of Bruton's tyrosine kinase activity"}
{"concept_id": "C3895811", "aliases": ["down-regulation of cytoplasmic protein tyrosine kinase activity", "downregulation of cytoplasmic protein tyrosine kinase activity", "negative regulation of cytoplasmic protein tyrosine kinase activity"], "types": ["T043"], "canonical_name": "down regulation of cytoplasmic protein tyrosine kinase activity"}
{"concept_id": "C3895812", "aliases": ["down-regulation of focal adhesion kinase activity", "downregulation of focal adhesion kinase activity", "negative regulation of focal adhesion kinase activity"], "types": ["T043"], "canonical_name": "down regulation of focal adhesion kinase activity"}
{"concept_id": "C3895813", "aliases": ["negative regulation of janus kinase 1 activity", "downregulation of janus kinase 1 activity", "down-regulation of janus kinase 1 activity"], "types": ["T043"], "canonical_name": "down regulation of janus kinase 1 activity"}
{"concept_id": "C3895814", "aliases": ["negative regulation of janus kinase 2 activity", "downregulation of janus kinase 2 activity", "down-regulation of janus kinase 2 activity"], "types": ["T043"], "canonical_name": "down regulation of janus kinase 2 activity"}
{"concept_id": "C3895815", "aliases": ["down-regulation of janus kinase 3 activity", "negative regulation of janus kinase 3 activity", "downregulation of janus kinase 3 activity"], "types": ["T043"], "canonical_name": "down regulation of janus kinase 3 activity"}
{"concept_id": "C3895816", "aliases": ["down-regulation of non-specific protein-tyrosine kinase activity", "negative regulation of non-specific protein-tyrosine kinase activity", "downregulation of non-specific protein-tyrosine kinase activity"], "types": ["T043"], "canonical_name": "down regulation of non-specific protein-tyrosine kinase activity"}
{"concept_id": "C3895817", "aliases": ["down-regulation of p60c-src protein tyrosine kinase activity"], "types": ["T043"], "canonical_name": "down regulation of p60c-src protein tyrosine kinase activity"}
{"concept_id": "C3895818", "aliases": ["negative regulation of p60c-src protein tyrosine kinase activity"], "types": ["T043"], "canonical_name": "downregulation of p60c-src protein tyrosine kinase activity"}
{"concept_id": "C3895819", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity"}
{"concept_id": "C3895820", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Bruton's tyrosine kinase activity"}
{"concept_id": "C3895821", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytoplasmic protein tyrosine kinase activity"}
{"concept_id": "C3895822", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of focal adhesion kinase activity"}
{"concept_id": "C3895823", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of janus kinase 1 activity"}
{"concept_id": "C3895824", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of janus kinase 2 activity"}
{"concept_id": "C3895825", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of janus kinase 3 activity"}
{"concept_id": "C3895826", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of non-membrane spanning protein tyrosine kinase activity"}
{"concept_id": "C3895827", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of non-specific protein-tyrosine kinase activity"}
{"concept_id": "C3895828", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of p60c-src protein tyrosine kinase activity"}
{"concept_id": "C3895829", "aliases": ["up regulation of non-membrane spanning protein tyrosine kinase activity", "upregulation of non-membrane spanning protein tyrosine kinase activity", "up-regulation of non-membrane spanning protein tyrosine kinase activity"], "types": ["T043"], "canonical_name": "positive regulation of non-membrane spanning protein tyrosine kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]"}
{"concept_id": "C3895830", "aliases": [], "types": ["T043"], "canonical_name": "activation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity"}
{"concept_id": "C3895831", "aliases": [], "types": ["T043"], "canonical_name": "activation of Bruton's tyrosine kinase activity"}
{"concept_id": "C3895832", "aliases": [], "types": ["T043"], "canonical_name": "activation of cytoplasmic protein tyrosine kinase activity"}
{"concept_id": "C3895833", "aliases": [], "types": ["T043"], "canonical_name": "activation of focal adhesion kinase activity"}
{"concept_id": "C3895834", "aliases": [], "types": ["T043"], "canonical_name": "activation of janus kinase 1 activity"}
{"concept_id": "C3895835", "aliases": [], "types": ["T043"], "canonical_name": "activation of janus kinase 2 activity"}
{"concept_id": "C3895836", "aliases": [], "types": ["T043"], "canonical_name": "activation of janus kinase 3 activity"}
{"concept_id": "C3895837", "aliases": [], "types": ["T043"], "canonical_name": "activation of non-membrane spanning protein tyrosine kinase activity"}
{"concept_id": "C3895838", "aliases": [], "types": ["T043"], "canonical_name": "activation of non-specific protein-tyrosine kinase activity"}
{"concept_id": "C3895839", "aliases": [], "types": ["T043"], "canonical_name": "activation of p60c-src protein tyrosine kinase activity"}
{"concept_id": "C3895840", "aliases": ["up-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity", "up regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity", "upregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity"], "types": ["T043"], "canonical_name": "positive regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity"}
{"concept_id": "C3895841", "aliases": ["up regulation of Bruton's tyrosine kinase activity", "upregulation of Bruton's tyrosine kinase activity", "up-regulation of Bruton's tyrosine kinase activity"], "types": ["T043"], "canonical_name": "positive regulation of Bruton's tyrosine kinase activity"}
{"concept_id": "C3895842", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cytoplasmic protein tyrosine kinase activity"}
{"concept_id": "C3895843", "aliases": ["up regulation of focal adhesion kinase activity", "upregulation of focal adhesion kinase activity", "up-regulation of focal adhesion kinase activity"], "types": ["T043"], "canonical_name": "positive regulation of focal adhesion kinase activity"}
{"concept_id": "C3895844", "aliases": ["up regulation of janus kinase 1 activity", "upregulation of janus kinase 1 activity", "up-regulation of janus kinase 1 activity"], "types": ["T043"], "canonical_name": "positive regulation of janus kinase 1 activity"}
{"concept_id": "C3895845", "aliases": ["upregulation of janus kinase 2 activity", "up-regulation of janus kinase 2 activity", "up regulation of janus kinase 2 activity"], "types": ["T043"], "canonical_name": "positive regulation of janus kinase 2 activity"}
{"concept_id": "C3895846", "aliases": ["up-regulation of janus kinase 3 activity", "up regulation of janus kinase 3 activity", "upregulation of janus kinase 3 activity"], "types": ["T043"], "canonical_name": "positive regulation of janus kinase 3 activity"}
{"concept_id": "C3895847", "aliases": ["up-regulation of non-specific protein-tyrosine kinase activity", "upregulation of non-specific protein-tyrosine kinase activity", "up regulation of non-specific protein-tyrosine kinase activity"], "types": ["T043"], "canonical_name": "positive regulation of non-specific protein-tyrosine kinase activity"}
{"concept_id": "C3895848", "aliases": ["upregulation of p60c-src protein tyrosine kinase activity"], "types": ["T043"], "canonical_name": "positive regulation of p60c-src protein tyrosine kinase activity"}
{"concept_id": "C3895849", "aliases": ["up-regulation of cytoplasmic protein tyrosine kinase activity", "upregulation of cytoplasmic protein tyrosine kinase activity"], "types": ["T043"], "canonical_name": "up regulation of cytoplasmic protein tyrosine kinase activity"}
{"concept_id": "C3895850", "aliases": ["up-regulation of p60c-src protein tyrosine kinase activity"], "types": ["T043"], "canonical_name": "up regulation of p60c-src protein tyrosine kinase activity"}
{"concept_id": "C3895851", "aliases": ["regulation of eating behaviour"], "types": ["T055"], "canonical_name": "regulation of eating behavior", "definition": "Any process that modulates the frequency, rate or extent of eating behavior. [GO_REF:0000058, GOC:TermGenie, PMID:11961051]"}
{"concept_id": "C3895852", "aliases": ["down-regulation of eating behaviour", "negative regulation of eating behaviour", "down regulation of eating behavior", "down-regulation of eating behavior", "downregulation of eating behavior", "downregulation of eating behaviour", "down regulation of eating behaviour"], "types": ["T055"], "canonical_name": "negative regulation of eating behavior", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior. [GO_REF:0000058, GOC:TermGenie, PMID:11961051]"}
{"concept_id": "C3895853", "aliases": ["inhibition of eating behaviour"], "types": ["T055"], "canonical_name": "inhibition of eating behavior"}
{"concept_id": "C3895854", "aliases": ["up regulation of eating behavior", "positive regulation of eating behaviour", "up-regulation of eating behavior", "upregulation of eating behaviour", "up regulation of eating behaviour", "upregulation of eating behavior", "up-regulation of eating behaviour"], "types": ["T055"], "canonical_name": "positive regulation of eating behavior", "definition": "Any process that activates or increases the frequency, rate or extent of eating behavior. [GO_REF:0000058, GOC:TermGenie, PMID:11961051]"}
{"concept_id": "C3895855", "aliases": ["activation of eating behaviour"], "types": ["T055"], "canonical_name": "activation of eating behavior"}
{"concept_id": "C3895860", "aliases": ["regulation of sebocyte proliferation"], "types": ["T043"], "canonical_name": "regulation of sebum secreting cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of sebum secreting cell proliferation. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790]"}
{"concept_id": "C3895861", "aliases": ["negative regulation of sebocyte proliferation", "downregulation of sebocyte proliferation", "down regulation of sebocyte proliferation", "down-regulation of sebum secreting cell proliferation", "downregulation of sebum secreting cell proliferation", "down regulation of sebum secreting cell proliferation", "down-regulation of sebocyte proliferation"], "types": ["T043"], "canonical_name": "negative regulation of sebum secreting cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sebum secreting cell proliferation. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790]"}
{"concept_id": "C3895862", "aliases": ["inhibition of sebum secreting cell proliferation"], "types": ["T043"], "canonical_name": "inhibition of sebocyte proliferation"}
{"concept_id": "C3895863", "aliases": ["up regulation of sebocyte proliferation", "positive regulation of sebocyte proliferation", "up-regulation of sebocyte proliferation", "upregulation of sebocyte proliferation", "upregulation of sebum secreting cell proliferation", "up regulation of sebum secreting cell proliferation", "up-regulation of sebum secreting cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of sebum secreting cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of sebum secreting cell proliferation. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790]"}
{"concept_id": "C3895864", "aliases": ["activation of sebum secreting cell proliferation"], "types": ["T043"], "canonical_name": "activation of sebocyte proliferation"}
{"concept_id": "C3895865", "aliases": ["regulation of choline phosphatase activity", "regulation of phosphatidylcholine phosphatidohydrolase activity", "regulation of lipophosphodiesterase II activity", "regulation of lecithinase D activity"], "types": ["T040"], "canonical_name": "regulation of phospholipase D activity", "definition": "Any process that modulates the frequency, rate or extent of phospholipase D activity. [GO_REF:0000059, GOC:TermGenie, PMID:11211872]"}
{"concept_id": "C3895867", "aliases": ["down-regulation of choline phosphatase activity", "down regulation of lipophosphodiesterase II activity", "down regulation of phospholipase D activity", "downregulation of lipophosphodiesterase II activity", "downregulation of phospholipase D activity", "negative regulation of lecithinase D activity", "downregulation of choline phosphatase activity", "down-regulation of phospholipase D activity", "down regulation of choline phosphatase activity", "down regulation of lecithinase D activity", "negative regulation of choline phosphatase activity", "negative regulation of lipophosphodiesterase II activity", "downregulation of lecithinase D activity", "down-regulation of lipophosphodiesterase II activity", "down-regulation of lecithinase D activity"], "types": ["T044"], "canonical_name": "negative regulation of phospholipase D activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase D activity. [GO_REF:0000059, GOC:TermGenie, PMID:11211872]"}
{"concept_id": "C3895868", "aliases": ["down-regulation of phosphatidylcholine phosphatidohydrolase activity", "negative regulation of phosphatidylcholine phosphatidohydrolase activity", "downregulation of phosphatidylcholine phosphatidohydrolase activity"], "types": ["T044"], "canonical_name": "down regulation of phosphatidylcholine phosphatidohydrolase activity"}
{"concept_id": "C3895869", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of choline phosphatase activity"}
{"concept_id": "C3895870", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lecithinase D activity"}
{"concept_id": "C3895871", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lipophosphodiesterase II activity"}
{"concept_id": "C3895872", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylcholine phosphatidohydrolase activity"}
{"concept_id": "C3895873", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phospholipase D activity"}
{"concept_id": "C3895874", "aliases": ["up-regulation of lecithinase D activity", "up regulation of choline phosphatase activity", "positive regulation of lecithinase D activity", "up-regulation of phospholipase D activity", "up-regulation of lipophosphodiesterase II activity", "up-regulation of choline phosphatase activity", "positive regulation of choline phosphatase activity", "positive regulation of lipophosphodiesterase II activity", "upregulation of phospholipase D activity", "upregulation of lipophosphodiesterase II activity", "up regulation of lecithinase D activity", "up regulation of lipophosphodiesterase II activity", "upregulation of choline phosphatase activity", "upregulation of lecithinase D activity", "up regulation of phospholipase D activity"], "types": ["T044"], "canonical_name": "positive regulation of phospholipase D activity", "definition": "Any process that activates or increases the frequency, rate or extent of phospholipase D activity. [GO_REF:0000059, GOC:TermGenie, PMID:11211872]"}
{"concept_id": "C3895875", "aliases": [], "types": ["T044"], "canonical_name": "activation of choline phosphatase activity"}
{"concept_id": "C3895876", "aliases": [], "types": ["T044"], "canonical_name": "activation of lecithinase D activity"}
{"concept_id": "C3895877", "aliases": [], "types": ["T044"], "canonical_name": "activation of lipophosphodiesterase II activity"}
{"concept_id": "C3895878", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylcholine phosphatidohydrolase activity"}
{"concept_id": "C3895879", "aliases": ["upregulation of phosphatidylcholine phosphatidohydrolase activity", "up regulation of phosphatidylcholine phosphatidohydrolase activity", "up-regulation of phosphatidylcholine phosphatidohydrolase activity"], "types": ["T044"], "canonical_name": "positive regulation of phosphatidylcholine phosphatidohydrolase activity"}
{"concept_id": "C3895880", "aliases": [], "types": ["T043"], "canonical_name": "response to monosodium glutamate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20704590]"}
{"concept_id": "C3895881", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to monosodium glutamate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20704590]"}
{"concept_id": "C3895882", "aliases": [], "types": ["T043"], "canonical_name": "response to Aroclor 1254", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18602130]"}
{"concept_id": "C3895883", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to Aroclor 1254", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18602130]"}
{"concept_id": "C3895886", "aliases": [], "types": ["T043"], "canonical_name": "response to serotonin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:1505525]"}
{"concept_id": "C3895887", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to serotonin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:1505525]"}
{"concept_id": "C3895888", "aliases": [], "types": ["T043"], "canonical_name": "response to Thyroglobulin triiodothyronine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:7531505]"}
{"concept_id": "C3895889", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to Thyroglobulin triiodothyronine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:7531505]"}
{"concept_id": "C3895890", "aliases": ["up regulation of vasculature development", "upregulation of vasculature development", "up-regulation of vasculature development"], "types": ["T039"], "canonical_name": "positive regulation of vasculature development", "definition": "Any process that activates or increases the frequency, rate or extent of vasculature development. [GO_REF:0000058, GOC:TermGenie, PMID:21472453]"}
{"concept_id": "C3895891", "aliases": [], "types": ["T039"], "canonical_name": "activation of vascular system development"}
{"concept_id": "C3895892", "aliases": [], "types": ["T039"], "canonical_name": "activation of vasculature development"}
{"concept_id": "C3895893", "aliases": ["up-regulation of vascular system development", "upregulation of vascular system development", "up regulation of vascular system development"], "types": ["T039"], "canonical_name": "positive regulation of vascular system development"}
{"concept_id": "C3895894", "aliases": ["epitheliocyte apoptosis", "epitheliocyte apoptotic process", "epithelial cell apoptosis"], "types": ["T043"], "canonical_name": "epithelial cell apoptotic process", "definition": "Any apoptotic process in an epithelial cell. [GO_REF:0000085, GOC:TermGenie, PMID:19137015]"}
{"concept_id": "C3895895", "aliases": ["regulation of G-protein-coupled receptor internalization"], "types": ["T043"], "canonical_name": "regulation of G protein-coupled receptor internalization", "definition": "Any process that modulates the frequency, rate or extent of G protein-coupled receptor internalization. [GO_REF:0000058, GOC:TermGenie, PMID:24732013]"}
{"concept_id": "C3895896", "aliases": ["negative regulation of G-protein coupled receptor internalization", "downregulation of G-protein coupled receptor internalization", "down regulation of G-protein coupled receptor internalization", "down-regulation of G-protein coupled receptor internalization"], "types": ["T043"], "canonical_name": "negative regulation of G protein-coupled receptor internalization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of G protein-coupled receptor internalization. [GO_REF:0000058, GOC:TermGenie, PMID:24732013]"}
{"concept_id": "C3895897", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of G-protein coupled receptor internalization"}
{"concept_id": "C3895898", "aliases": ["positive regulation of G-protein coupled receptor internalization", "up regulation of G-protein coupled receptor internalization", "up-regulation of G-protein coupled receptor internalization", "upregulation of G-protein coupled receptor internalization"], "types": ["T043"], "canonical_name": "positive regulation of G protein-coupled receptor internalization", "definition": "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor internalization. [GO_REF:0000058, GOC:TermGenie, PMID:24732013]"}
{"concept_id": "C3895899", "aliases": [], "types": ["T043"], "canonical_name": "activation of G-protein coupled receptor internalization"}
{"concept_id": "C3895900", "aliases": ["regulation of homofermentation", "regulation of homolactic fermentation", "regulation of homolactate fermentation", "regulation of homofermentative pathway", "regulation of homofermentative lactate fermentation", "regulation of glucose fermentation to lactate via pyruvate"], "types": ["T044"], "canonical_name": "regulation of glucose catabolic process to lactate via pyruvate", "definition": "Any process that modulates the frequency, rate or extent of glucose catabolic process to lactate via pyruvate. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]"}
{"concept_id": "C3895901", "aliases": ["down regulation of homolactate fermentation", "downregulation of homofermentation", "downregulation of homolactic fermentation", "down regulation of homolactic fermentation", "down-regulation of homofermentative lactate fermentation", "downregulation of glucose catabolic process to lactate via pyruvate", "downregulation of homofermentative pathway", "down-regulation of homofermentative pathway", "down-regulation of glucose catabolic process to lactate via pyruvate", "downregulation of glucose fermentation to lactate via pyruvate", "down regulation of homofermentative lactate fermentation", "down-regulation of homolactic fermentation", "down-regulation of glucose fermentation to lactate via pyruvate", "down regulation of homofermentation", "downregulation of homolactate fermentation", "down-regulation of homofermentation", "downregulation of homofermentative lactate fermentation", "negative regulation of glucose fermentation to lactate via pyruvate", "down-regulation of homolactate fermentation", "negative regulation of homofermentative lactate fermentation", "negative regulation of homolactic fermentation", "negative regulation of homofermentative pathway", "down regulation of glucose catabolic process to lactate via pyruvate", "down regulation of glucose fermentation to lactate via pyruvate", "negative regulation of homolactate fermentation", "negative regulation of homofermentation", "down regulation of homofermentative pathway"], "types": ["T044"], "canonical_name": "negative regulation of glucose catabolic process to lactate via pyruvate", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]"}
{"concept_id": "C3895902", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucose catabolic process to lactate via pyruvate"}
{"concept_id": "C3895903", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucose fermentation to lactate via pyruvate"}
{"concept_id": "C3895904", "aliases": ["inhibition of homofermentative pathway"], "types": ["T044"], "canonical_name": "inhibition of homofermentation"}
{"concept_id": "C3895905", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of homofermentative lactate fermentation"}
{"concept_id": "C3895906", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of homolactate fermentation"}
{"concept_id": "C3895907", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of homolactic fermentation"}
{"concept_id": "C3895908", "aliases": ["up regulation of homolactate fermentation", "up regulation of glucose fermentation to lactate via pyruvate", "positive regulation of glucose fermentation to lactate via pyruvate", "upregulation of homofermentative pathway", "positive regulation of homofermentative lactate fermentation", "upregulation of glucose fermentation to lactate via pyruvate", "up regulation of glucose catabolic process to lactate via pyruvate", "up regulation of homolactic fermentation", "positive regulation of homolactic fermentation", "upregulation of homolactate fermentation", "up-regulation of glucose catabolic process to lactate via pyruvate", "positive regulation of homolactate fermentation", "up-regulation of homofermentative lactate fermentation", "upregulation of homofermentation", "up-regulation of glucose fermentation to lactate via pyruvate", "up regulation of homofermentation", "up regulation of homofermentative pathway", "upregulation of homofermentative lactate fermentation", "up-regulation of homolactate fermentation", "positive regulation of homofermentation", "positive regulation of homofermentative pathway", "upregulation of homolactic fermentation", "up regulation of homofermentative lactate fermentation", "up-regulation of homofermentation", "up-regulation of homofermentative pathway", "upregulation of glucose catabolic process to lactate via pyruvate", "up-regulation of homolactic fermentation"], "types": ["T044"], "canonical_name": "positive regulation of glucose catabolic process to lactate via pyruvate", "definition": "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to lactate via pyruvate. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]"}
{"concept_id": "C3895909", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucose catabolic process to lactate via pyruvate"}
{"concept_id": "C3895910", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucose fermentation to lactate via pyruvate"}
{"concept_id": "C3895911", "aliases": ["activation of homofermentative pathway"], "types": ["T044"], "canonical_name": "activation of homofermentation"}
{"concept_id": "C3895912", "aliases": [], "types": ["T044"], "canonical_name": "activation of homofermentative lactate fermentation"}
{"concept_id": "C3895913", "aliases": [], "types": ["T044"], "canonical_name": "activation of homolactate fermentation"}
{"concept_id": "C3895914", "aliases": [], "types": ["T044"], "canonical_name": "activation of homolactic fermentation"}
{"concept_id": "C3895915", "aliases": ["regulation of collagen fibril organisation", "regulation of fibrillar collagen organization"], "types": ["T043"], "canonical_name": "regulation of collagen fibril organization", "definition": "Any process that modulates the frequency, rate or extent of collagen fibril organization. [GO_REF:0000058, GOC:TermGenie, PMID:25451920]"}
{"concept_id": "C3895916", "aliases": [], "types": ["T043"], "canonical_name": "regulation of collagen fibrillogenesis"}
{"concept_id": "C3895917", "aliases": ["down regulation of collagen fibril organization", "downregulation of fibrillar collagen organization", "negative regulation of collagen fibril organisation", "downregulation of collagen fibril organization", "downregulation of collagen fibril organisation", "down regulation of fibrillar collagen organization", "negative regulation of fibrillar collagen organization", "down-regulation of fibrillar collagen organization", "down regulation of collagen fibril organisation", "down-regulation of collagen fibril organisation", "down-regulation of collagen fibril organization"], "types": ["T043"], "canonical_name": "negative regulation of collagen fibril organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization. [GO_REF:0000058, GOC:TermGenie, PMID:25451920]"}
{"concept_id": "C3895918", "aliases": ["inhibition of collagen fibril organization"], "types": ["T043"], "canonical_name": "inhibition of collagen fibril organisation"}
{"concept_id": "C3895919", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fibrillar collagen organization"}
{"concept_id": "C3895920", "aliases": ["up-regulation of fibrillar collagen organization", "upregulation of fibrillar collagen organization", "positive regulation of collagen fibril organisation", "upregulation of collagen fibril organization", "positive regulation of fibrillar collagen organization", "up regulation of collagen fibril organization", "up-regulation of collagen fibril organization", "upregulation of collagen fibril organisation", "up-regulation of collagen fibril organisation", "up regulation of fibrillar collagen organization", "up regulation of collagen fibril organisation"], "types": ["T043"], "canonical_name": "positive regulation of collagen fibril organization", "definition": "Any process that activates or increases the frequency, rate or extent of collagen fibril organization. [GO_REF:0000058, GOC:TermGenie, PMID:25451920]"}
{"concept_id": "C3895921", "aliases": ["activation of collagen fibril organization"], "types": ["T043"], "canonical_name": "activation of collagen fibril organisation"}
{"concept_id": "C3895922", "aliases": [], "types": ["T043"], "canonical_name": "activation of fibrillar collagen organization"}
{"concept_id": "C3895923", "aliases": [], "types": ["T043"], "canonical_name": "regulation of t-SNARE clustering", "definition": "Any process that modulates the frequency, rate or extent of t-SNARE clustering. [GO_REF:0000058, GOC:TermGenie, PMID:22528485]"}
{"concept_id": "C3895924", "aliases": ["down regulation of t-SNARE clustering", "down-regulation of t-SNARE clustering", "downregulation of t-SNARE clustering"], "types": ["T043"], "canonical_name": "negative regulation of t-SNARE clustering", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of t-SNARE clustering. [GO_REF:0000058, GOC:TermGenie, PMID:22528485]"}
{"concept_id": "C3895925", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of t-SNARE clustering"}
{"concept_id": "C3895926", "aliases": ["upregulation of t-SNARE clustering", "up-regulation of t-SNARE clustering", "up regulation of t-SNARE clustering"], "types": ["T043"], "canonical_name": "positive regulation of t-SNARE clustering", "definition": "Any process that activates or increases the frequency, rate or extent of t-SNARE clustering. [GO_REF:0000058, GOC:TermGenie, PMID:22528485]"}
{"concept_id": "C3895927", "aliases": [], "types": ["T043"], "canonical_name": "activation of t-SNARE clustering"}
{"concept_id": "C3895928", "aliases": ["regulation of epitheliocyte apoptosis", "regulation of epitheliocyte apoptotic process", "regulation of epithelial cell apoptosis"], "types": ["T043"], "canonical_name": "regulation of epithelial cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19137015]"}
{"concept_id": "C3895929", "aliases": ["down regulation of epitheliocyte apoptotic process", "down-regulation of epithelial cell apoptosis", "down regulation of epithelial cell apoptosis", "downregulation of epithelial cell apoptotic process", "down-regulation of epitheliocyte apoptotic process", "down regulation of epithelial cell apoptotic process", "downregulation of epithelial cell apoptosis", "down-regulation of epithelial cell apoptotic process", "down regulation of epitheliocyte apoptosis", "downregulation of epitheliocyte apoptotic process", "downregulation of epitheliocyte apoptosis", "down-regulation of epitheliocyte apoptosis", "negative regulation of epitheliocyte apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of epithelial cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19137015]"}
{"concept_id": "C3895930", "aliases": ["inhibition of epithelial cell apoptotic process", "inhibition of epitheliocyte apoptotic process", "inhibition of epitheliocyte apoptosis"], "types": ["T043"], "canonical_name": "inhibition of epithelial cell apoptosis"}
{"concept_id": "C3895931", "aliases": ["negative regulation of epitheliocyte apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of epithelial cell apoptosis"}
{"concept_id": "C3895932", "aliases": ["upregulation of epithelial cell apoptotic process", "up regulation of epitheliocyte apoptotic process", "upregulation of epitheliocyte apoptotic process", "positive regulation of epitheliocyte apoptotic process", "up regulation of epithelial cell apoptotic process", "up-regulation of epitheliocyte apoptotic process", "up-regulation of epithelial cell apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of epithelial cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19137015]"}
{"concept_id": "C3895933", "aliases": ["activation of epithelial cell apoptotic process", "activation of epitheliocyte apoptosis", "activation of epitheliocyte apoptotic process"], "types": ["T043"], "canonical_name": "activation of epithelial cell apoptosis"}
{"concept_id": "C3895934", "aliases": ["up regulation of epithelial cell apoptosis", "up-regulation of epitheliocyte apoptosis", "up-regulation of epithelial cell apoptosis", "positive regulation of epitheliocyte apoptosis", "upregulation of epitheliocyte apoptosis", "up regulation of epitheliocyte apoptosis", "upregulation of epithelial cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of epithelial cell apoptosis"}
{"concept_id": "C3895935", "aliases": ["regulation of iron(2+) export"], "types": ["T043"], "canonical_name": "regulation of ferrous iron export"}
{"concept_id": "C3895936", "aliases": ["downregulation of ferrous iron export", "down regulation of iron(2+) export", "negative regulation of iron(2+) export", "down regulation of ferrous iron export", "downregulation of iron(2+) export", "down-regulation of iron(2+) export", "down-regulation of ferrous iron export"], "types": ["T043"], "canonical_name": "negative regulation of ferrous iron export"}
{"concept_id": "C3895937", "aliases": ["inhibition of iron(2+) export"], "types": ["T043"], "canonical_name": "inhibition of ferrous iron export"}
{"concept_id": "C3895938", "aliases": ["positive regulation of iron(2+) export", "up-regulation of ferrous iron export", "up-regulation of iron(2+) export", "up regulation of iron(2+) export", "up regulation of ferrous iron export", "upregulation of iron(2+) export", "upregulation of ferrous iron export"], "types": ["T043"], "canonical_name": "positive regulation of ferrous iron export"}
{"concept_id": "C3895939", "aliases": ["activation of iron(2+) export"], "types": ["T043"], "canonical_name": "activation of ferrous iron export"}
{"concept_id": "C3895940", "aliases": ["regulation of serine sulfhydrylase activity", "regulation of beta-thionase activity", "regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "regulation of serine sulfhydrase activity", "regulation of methylcysteine synthase activity", "regulation of L-serine hydro-lyase (adding homocysteine)"], "types": ["T044"], "canonical_name": "regulation of cystathionine beta-synthase activity", "definition": "Any process that modulates the frequency, rate or extent of cystathionine beta-synthase activity. [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422]"}
{"concept_id": "C3895941", "aliases": ["down regulation of serine sulfhydrase activity", "negative regulation of beta-thionase activity", "down-regulation of methylcysteine synthase activity", "negative regulation of methylcysteine synthase activity", "down regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "negative regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "down regulation of serine sulfhydrylase activity", "down-regulation of serine sulfhydrase activity", "negative regulation of L-serine hydro-lyase (adding homocysteine)", "downregulation of cystathionine beta-synthase activity", "down-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "down regulation of methylcysteine synthase activity", "downregulation of methylcysteine synthase activity", "downregulation of serine sulfhydrase activity", "negative regulation of serine sulfhydrase activity", "down-regulation of serine sulfhydrylase activity", "downregulation of L-serine hydro-lyase (adding homocysteine)", "negative regulation of serine sulfhydrylase activity", "down-regulation of beta-thionase activity", "down-regulation of L-serine hydro-lyase (adding homocysteine)", "down regulation of beta-thionase activity", "downregulation of beta-thionase activity", "down-regulation of cystathionine beta-synthase activity", "down regulation of cystathionine beta-synthase activity", "downregulation of serine sulfhydrylase activity", "down regulation of L-serine hydro-lyase (adding homocysteine)", "downregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)"], "types": ["T044"], "canonical_name": "negative regulation of cystathionine beta-synthase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cystathionine beta-synthase activity. [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422]"}
{"concept_id": "C3895942", "aliases": ["inhibition of serine sulfhydrase activity", "inhibition of beta-thionase activity", "inhibition of cystathionine beta-synthase activity", "inhibition of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "inhibition of methylcysteine synthase activity", "inhibition of serine sulfhydrylase activity"], "types": ["T044"], "canonical_name": "inhibition of L-serine hydro-lyase (adding homocysteine)"}
{"concept_id": "C3895943", "aliases": ["upregulation of cystathionine beta-synthase activity", "up-regulation of beta-thionase activity", "up-regulation of L-serine hydro-lyase (adding homocysteine)", "up-regulation of serine sulfhydrylase activity", "upregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "up-regulation of serine sulfhydrase activity", "positive regulation of L-serine hydro-lyase (adding homocysteine)", "up regulation of L-serine hydro-lyase (adding homocysteine)", "up regulation of beta-thionase activity", "positive regulation of methylcysteine synthase activity", "up-regulation of methylcysteine synthase activity", "up regulation of cystathionine beta-synthase activity", "positive regulation of beta-thionase activity", "up regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "upregulation of serine sulfhydrylase activity", "positive regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "positive regulation of serine sulfhydrase activity", "upregulation of L-serine hydro-lyase (adding homocysteine)", "positive regulation of serine sulfhydrylase activity", "up-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "upregulation of serine sulfhydrase activity", "up regulation of methylcysteine synthase activity", "upregulation of methylcysteine synthase activity", "up-regulation of cystathionine beta-synthase activity", "upregulation of beta-thionase activity", "up regulation of serine sulfhydrylase activity", "up regulation of serine sulfhydrase activity"], "types": ["T044"], "canonical_name": "positive regulation of cystathionine beta-synthase activity", "definition": "Any process that activates or increases the frequency, rate or extent of cystathionine beta-synthase activity. [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422]"}
{"concept_id": "C3895944", "aliases": ["activation of beta-thionase activity", "activation of serine sulfhydrase activity", "activation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)", "activation of serine sulfhydrylase activity", "activation of cystathionine beta-synthase activity", "activation of methylcysteine synthase activity"], "types": ["T044"], "canonical_name": "activation of L-serine hydro-lyase (adding homocysteine)"}
{"concept_id": "C3895945", "aliases": [], "types": ["T043"], "canonical_name": "response to aldosterone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17644563]"}
{"concept_id": "C3895946", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to aldosterone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17644563]"}
{"concept_id": "C3895947", "aliases": ["negative regulation of VEGF production", "down regulation of VEGF production", "down regulation of vascular endothelial growth factor production", "downregulation of VEGF production", "down-regulation of vascular endothelial growth factor production", "down-regulation of VEGF production", "downregulation of vascular endothelial growth factor production"], "types": ["T040"], "canonical_name": "negative regulation of vascular endothelial growth factor production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production. [GO_REF:0000058, GOC:TermGenie, PMID:19404486]"}
{"concept_id": "C3895948", "aliases": ["inhibition of vascular endothelial growth factor production"], "types": ["T040"], "canonical_name": "inhibition of VEGF production"}
{"concept_id": "C3895949", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine binding", "definition": "Binding to S-adenosyl-L-methionine. [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]"}
{"concept_id": "C3895950", "aliases": ["regulation of stimulus-independent neurotransmitter secretion"], "types": ["T043"], "canonical_name": "regulation of spontaneous neurotransmitter secretion", "definition": "Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364]"}
{"concept_id": "C3895951", "aliases": ["down-regulation of stimulus-independent neurotransmitter secretion", "negative regulation of stimulus-independent neurotransmitter secretion", "down regulation of spontaneous neurotransmitter secretion", "downregulation of spontaneous neurotransmitter secretion", "down-regulation of spontaneous neurotransmitter secretion", "downregulation of stimulus-independent neurotransmitter secretion", "down regulation of stimulus-independent neurotransmitter secretion"], "types": ["T043"], "canonical_name": "negative regulation of spontaneous neurotransmitter secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364]"}
{"concept_id": "C3895952", "aliases": ["inhibition of stimulus-independent neurotransmitter secretion"], "types": ["T043"], "canonical_name": "inhibition of spontaneous neurotransmitter secretion"}
{"concept_id": "C3895953", "aliases": ["positive regulation of stimulus-independent neurotransmitter secretion", "up regulation of spontaneous neurotransmitter secretion", "upregulation of spontaneous neurotransmitter secretion", "up-regulation of spontaneous neurotransmitter secretion", "up regulation of stimulus-independent neurotransmitter secretion", "upregulation of stimulus-independent neurotransmitter secretion", "up-regulation of stimulus-independent neurotransmitter secretion"], "types": ["T043"], "canonical_name": "positive regulation of spontaneous neurotransmitter secretion", "definition": "Any process that activates or increases the frequency, rate or extent of spontaneous neurotransmitter secretion. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364]"}
{"concept_id": "C3895954", "aliases": ["activation of stimulus-independent neurotransmitter secretion"], "types": ["T043"], "canonical_name": "activation of spontaneous neurotransmitter secretion"}
{"concept_id": "C3895955", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein targeting to vacuole involved in autophagy", "definition": "Any process that modulates the frequency, rate or extent of protein targeting to vacuole involved in autophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]"}
{"concept_id": "C3895956", "aliases": ["down regulation of protein targeting to vacuole involved in autophagy", "down-regulation of protein targeting to vacuole involved in autophagy", "downregulation of protein targeting to vacuole involved in autophagy"], "types": ["T043"], "canonical_name": "negative regulation of protein targeting to vacuole involved in autophagy", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuole involved in autophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]"}
{"concept_id": "C3895957", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein targeting to vacuole involved in autophagy"}
{"concept_id": "C3895958", "aliases": ["upregulation of protein targeting to vacuole involved in autophagy", "up regulation of protein targeting to vacuole involved in autophagy", "up-regulation of protein targeting to vacuole involved in autophagy"], "types": ["T043"], "canonical_name": "positive regulation of protein targeting to vacuole involved in autophagy", "definition": "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuole involved in autophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]"}
{"concept_id": "C3895959", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein targeting to vacuole involved in autophagy"}
{"concept_id": "C3895960", "aliases": ["regulation of hepatoblast proliferation"], "types": ["T043"], "canonical_name": "regulation of cholangiocyte proliferation", "definition": "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24434010]"}
{"concept_id": "C3895961", "aliases": ["downregulation of cholangiocyte proliferation", "down-regulation of cholangiocyte proliferation", "down regulation of cholangiocyte proliferation"], "types": ["T043"], "canonical_name": "negative regulation of cholangiocyte proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24434010]"}
{"concept_id": "C3895962", "aliases": ["negative regulation of hepatoblast proliferation", "down-regulation of hepatoblast proliferation", "downregulation of hepatoblast proliferation"], "types": ["T043"], "canonical_name": "down regulation of hepatoblast proliferation"}
{"concept_id": "C3895963", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cholangiocyte proliferation"}
{"concept_id": "C3895964", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hepatoblast proliferation"}
{"concept_id": "C3895965", "aliases": ["up regulation of cholangiocyte proliferation", "upregulation of cholangiocyte proliferation", "up-regulation of cholangiocyte proliferation"], "types": ["T043"], "canonical_name": "positive regulation of cholangiocyte proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24434010]"}
{"concept_id": "C3895966", "aliases": [], "types": ["T043"], "canonical_name": "activation of cholangiocyte proliferation"}
{"concept_id": "C3895967", "aliases": [], "types": ["T043"], "canonical_name": "activation of hepatoblast proliferation"}
{"concept_id": "C3895968", "aliases": ["up regulation of hepatoblast proliferation", "up-regulation of hepatoblast proliferation", "upregulation of hepatoblast proliferation"], "types": ["T043"], "canonical_name": "positive regulation of hepatoblast proliferation"}
{"concept_id": "C3895969", "aliases": ["down-regulation of nociception", "down regulation of nociception", "down-regulation of sensory perception of pain", "downregulation of sensory perception of pain", "down regulation of sensory perception of pain", "negative regulation of nociception", "downregulation of nociception"], "types": ["T040"], "canonical_name": "negative regulation of sensory perception of pain", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. [GO_REF:0000058, GOC:TermGenie, PMID:17167094]"}
{"concept_id": "C3895970", "aliases": ["downregulation of perception of physiological pain", "down-regulation of perception of physiological pain"], "types": ["T040"], "canonical_name": "down regulation of perception of physiological pain"}
{"concept_id": "C3895971", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of nociception"}
{"concept_id": "C3895972", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of perception of physiological pain"}
{"concept_id": "C3895973", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of sensory perception of pain"}
{"concept_id": "C3895974", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of perception of physiological pain"}
{"concept_id": "C3895975", "aliases": ["up-regulation of nociception", "up-regulation of sensory perception of pain", "upregulation of nociception", "positive regulation of nociception", "up regulation of nociception", "up regulation of sensory perception of pain", "upregulation of sensory perception of pain"], "types": ["T040"], "canonical_name": "positive regulation of sensory perception of pain", "definition": "Any process that activates or increases the frequency, rate or extent of sensory perception of pain. [GO_REF:0000058, GOC:TermGenie, PMID:17167094]"}
{"concept_id": "C3895976", "aliases": [], "types": ["T040"], "canonical_name": "activation of nociception"}
{"concept_id": "C3895977", "aliases": [], "types": ["T040"], "canonical_name": "activation of perception of physiological pain"}
{"concept_id": "C3895978", "aliases": [], "types": ["T040"], "canonical_name": "activation of sensory perception of pain"}
{"concept_id": "C3895979", "aliases": ["upregulation of perception of physiological pain", "up-regulation of perception of physiological pain", "up regulation of perception of physiological pain"], "types": ["T040"], "canonical_name": "positive regulation of perception of physiological pain"}
{"concept_id": "C3895980", "aliases": [], "types": ["T038"], "canonical_name": "regulation of locomotor rhythm", "definition": "Any process that modulates the frequency, rate or extent of locomotor rhythm. [GO_REF:0000058, GOC:TermGenie, PMID:16310969]"}
{"concept_id": "C3895981", "aliases": [], "types": ["T038"], "canonical_name": "regulation of circadian locomotor activity rhythm"}
{"concept_id": "C3895982", "aliases": ["downregulation of locomotor rhythm", "down regulation of locomotor rhythm", "down-regulation of locomotor rhythm"], "types": ["T039"], "canonical_name": "negative regulation of locomotor rhythm", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of locomotor rhythm. [GO_REF:0000058, GOC:TermGenie, PMID:16310969]"}
{"concept_id": "C3895983", "aliases": ["negative regulation of circadian locomotor activity rhythm", "down-regulation of circadian locomotor activity rhythm", "downregulation of circadian locomotor activity rhythm"], "types": ["T039"], "canonical_name": "down regulation of circadian locomotor activity rhythm"}
{"concept_id": "C3895984", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of circadian locomotor activity rhythm"}
{"concept_id": "C3895985", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of locomotor rhythm"}
{"concept_id": "C3895986", "aliases": ["up-regulation of locomotor rhythm", "upregulation of locomotor rhythm", "up regulation of locomotor rhythm"], "types": ["T039"], "canonical_name": "positive regulation of locomotor rhythm", "definition": "Any process that activates or increases the frequency, rate or extent of locomotor rhythm. [GO_REF:0000058, GOC:TermGenie, PMID:16310969]"}
{"concept_id": "C3895987", "aliases": [], "types": ["T039"], "canonical_name": "activation of circadian locomotor activity rhythm"}
{"concept_id": "C3895988", "aliases": [], "types": ["T039"], "canonical_name": "activation of locomotor rhythm"}
{"concept_id": "C3895989", "aliases": ["up regulation of circadian locomotor activity rhythm", "upregulation of circadian locomotor activity rhythm", "up-regulation of circadian locomotor activity rhythm"], "types": ["T039"], "canonical_name": "positive regulation of circadian locomotor activity rhythm"}
{"concept_id": "C3895990", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cation transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of cation transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:15304482]"}
{"concept_id": "C3895991", "aliases": ["downregulation of cation transmembrane transport", "down-regulation of cation transmembrane transport", "down regulation of cation transmembrane transport"], "types": ["T043"], "canonical_name": "negative regulation of cation transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:15304482]"}
{"concept_id": "C3895992", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cation transmembrane transport"}
{"concept_id": "C3895993", "aliases": ["up-regulation of cation transmembrane transport", "upregulation of cation transmembrane transport", "up regulation of cation transmembrane transport"], "types": ["T043"], "canonical_name": "positive regulation of cation transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:15304482]"}
{"concept_id": "C3895994", "aliases": [], "types": ["T043"], "canonical_name": "activation of cation transmembrane transport"}
{"concept_id": "C3895995", "aliases": ["muscarinic acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission", "muscarinic acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion", "G-protein coupled acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion", "acetylcholine receptor signalling, muscarinic pathway involved in positive regulation of acetylcholine secretion, neurotransmission", "acetylcholine receptor signalling, muscarinic pathway involved in up-regulation of acetylcholine secretion", "acetylcholine receptor signalling, muscarinic pathway involved in upregulation of acetylcholine secretion", "acetylcholine receptor signalling, muscarinic pathway involved in up regulation of acetylcholine secretion", "G-protein coupled acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion", "muscarinic acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion", "G-protein coupled acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion", "muscarinic acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion", "G-protein coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission"], "types": ["T044"], "canonical_name": "G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission", "definition": "Any G protein-coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission. [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22588719]"}
{"concept_id": "C3895996", "aliases": ["muscarinic acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion"], "types": ["T044"], "canonical_name": "acetylcholine receptor signalling, muscarinic pathway involved in activation of acetylcholine secretion"}
{"concept_id": "C3895997", "aliases": ["muscarinic acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion"], "types": ["T044"], "canonical_name": "acetylcholine receptor signalling, muscarinic pathway involved in stimulation of acetylcholine secretion"}
{"concept_id": "C3895998", "aliases": [], "types": ["T044"], "canonical_name": "G-protein coupled acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion"}
{"concept_id": "C3895999", "aliases": [], "types": ["T044"], "canonical_name": "G-protein coupled acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion"}
{"concept_id": "C3896000", "aliases": ["G-protein coupled receptor protein signaling pathway involved in dauer larval development", "GPCR signaling pathway involved in dauer larval development", "G protein coupled receptor protein signaling pathway involved in dauer larval development", "GPCR signalling pathway involved in dauer larval development", "G-protein-coupled receptor protein signalling pathway involved in dauer larval development", "G-protein coupled receptor signalling pathway involved in dauer larval development", "G protein coupled receptor protein signalling pathway involved in dauer larval development", "G-protein coupled receptor protein signal transduction involved in dauer larval development"], "types": ["T044"], "canonical_name": "G protein-coupled receptor signaling pathway involved in dauer larval development", "definition": "Any G protein-coupled receptor signaling pathway that is involved in dauer larval development. [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22665789]"}
{"concept_id": "C3896001", "aliases": [], "types": ["T044"], "canonical_name": "ascr#2 binding", "definition": "Binding to ascr#2. [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:22665789]"}
{"concept_id": "C3896002", "aliases": ["G protein coupled receptor protein signaling pathway involved in social behavior", "G-protein coupled receptor signaling pathway involved in social behaviour", "G-protein coupled receptor protein signal transduction involved in social behaviour", "GPCR signalling pathway involved in social behaviour", "G-protein-coupled receptor protein signaling pathway involved in social behaviour", "G-protein coupled receptor protein signal transduction involved in social behavior", "G-protein coupled receptor protein signaling pathway involved in social behavior", "G-protein coupled receptor protein signaling pathway involved in social behaviour", "GPCR signalling pathway involved in social behavior", "G-protein coupled receptor signaling pathway involved in social behavior", "G protein coupled receptor protein signalling pathway involved in social behaviour", "G protein coupled receptor protein signalling pathway involved in social behavior", "G protein coupled receptor protein signaling pathway involved in social behaviour", "GPCR signaling pathway involved in social behaviour", "G-protein-coupled receptor protein signalling pathway involved in social behaviour", "G-protein-coupled receptor protein signalling pathway involved in social behavior", "G-protein coupled receptor signalling pathway involved in social behaviour", "G-protein-coupled receptor protein signaling pathway involved in social behavior", "GPCR signaling pathway involved in social behavior", "G-protein coupled receptor signalling pathway involved in social behavior"], "types": ["T044"], "canonical_name": "G protein-coupled receptor signaling pathway involved in social behavior", "definition": "Any G protein-coupled receptor signaling pathway that is involved in social behavior. [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22665789]"}
{"concept_id": "C3896003", "aliases": ["G-protein coupled receptor protein signaling pathway involved in cooperative behavior", "G-protein-coupled receptor protein signalling pathway involved in cooperative behavior", "G protein coupled receptor protein signalling pathway involved in cooperative behavior", "G-protein-coupled receptor protein signaling pathway involved in cooperative behavior"], "types": ["T044"], "canonical_name": "G protein coupled receptor protein signaling pathway involved in cooperative behavior"}
{"concept_id": "C3896004", "aliases": [], "types": ["T044"], "canonical_name": "G-protein coupled receptor protein signal transduction involved in cooperative behavior"}
{"concept_id": "C3896005", "aliases": ["G-protein coupled receptor signalling pathway involved in cooperative behavior"], "types": ["T044"], "canonical_name": "G-protein coupled receptor signaling pathway involved in cooperative behavior"}
{"concept_id": "C3896006", "aliases": ["GPCR signalling pathway involved in cooperative behavior"], "types": ["T044"], "canonical_name": "GPCR signaling pathway involved in cooperative behavior"}
{"concept_id": "C3896007", "aliases": ["ascaroside metabolism"], "types": ["T044"], "canonical_name": "ascaroside metabolic process", "definition": "The chemical reactions and pathways involving ascaroside. [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:25775534]"}
{"concept_id": "C3896008", "aliases": ["ascaroside formation", "ascaroside biosynthesis", "ascaroside synthesis", "ascaroside anabolism"], "types": ["T044"], "canonical_name": "ascaroside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ascaroside. [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:25775534]"}
{"concept_id": "C3896009", "aliases": ["pre-synaptic active zone formation", "presynaptic active zone formation", "pre-synaptic active zone assembly"], "types": ["T043"], "canonical_name": "presynaptic active zone assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone. The presynaptic active zone is a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. [GO_REF:0000079, GOC:pr, GOC:TermGenie, PMID:10769383]"}
{"concept_id": "C3896010", "aliases": ["pre-synaptic active zone component formation"], "types": ["T043"], "canonical_name": "pre-synaptic active zone component assembly"}
{"concept_id": "C3896011", "aliases": ["pre-synaptic active zone disassembly"], "types": ["T043"], "canonical_name": "presynaptic active zone disassembly", "definition": "The disaggregation of a presynaptic active zone into its constituent components. [GO_REF:0000079, GOC:pr, GOC:TermGenie, ISBN:9780387325606]"}
{"concept_id": "C3896012", "aliases": [], "types": ["T043"], "canonical_name": "pre-synaptic active zone component disassembly"}
{"concept_id": "C3896013", "aliases": ["regulation of trophectoderm cell proliferation"], "types": ["T043"], "canonical_name": "regulation of trophectodermal cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24508636]"}
{"concept_id": "C3896014", "aliases": ["down-regulation of trophectodermal cell proliferation", "negative regulation of trophectoderm cell proliferation", "down regulation of trophectoderm cell proliferation", "downregulation of trophectodermal cell proliferation", "downregulation of trophectoderm cell proliferation", "down regulation of trophectodermal cell proliferation", "down-regulation of trophectoderm cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of trophectodermal cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24508636]"}
{"concept_id": "C3896015", "aliases": ["inhibition of trophectodermal cell proliferation"], "types": ["T043"], "canonical_name": "inhibition of trophectoderm cell proliferation"}
{"concept_id": "C3896016", "aliases": ["upregulation of trophectoderm cell proliferation", "up-regulation of trophectodermal cell proliferation", "positive regulation of trophectoderm cell proliferation", "up regulation of trophectoderm cell proliferation", "up regulation of trophectodermal cell proliferation", "upregulation of trophectodermal cell proliferation", "up-regulation of trophectoderm cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of trophectodermal cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24508636]"}
{"concept_id": "C3896017", "aliases": ["activation of trophectodermal cell proliferation"], "types": ["T043"], "canonical_name": "activation of trophectoderm cell proliferation"}
{"concept_id": "C3896018", "aliases": ["regulation of estrogen formation", "regulation of estrogen anabolism", "regulation of oestrogen biosynthesis", "regulation of estrogen synthesis", "regulation of estrogen biosynthesis", "regulation of oestrogen biosynthetic process"], "types": ["T044"], "canonical_name": "regulation of estrogen biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of estrogen biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:24530842]"}
{"concept_id": "C3896019", "aliases": ["down-regulation of estrogen formation", "down regulation of estrogen anabolism", "down regulation of estrogen biosynthesis", "down-regulation of oestrogen biosynthetic process", "negative regulation of oestrogen biosynthesis", "down regulation of estrogen formation", "downregulation of estrogen synthesis", "negative regulation of estrogen anabolism", "negative regulation of estrogen formation", "down-regulation of oestrogen biosynthesis", "down regulation of oestrogen biosynthesis", "downregulation of oestrogen biosynthesis", "down-regulation of estrogen synthesis", "down-regulation of estrogen biosynthesis", "downregulation of oestrogen biosynthetic process", "down-regulation of estrogen anabolism", "downregulation of estrogen biosynthesis", "down-regulation of estrogen biosynthetic process", "downregulation of estrogen anabolism", "negative regulation of estrogen biosynthesis", "negative regulation of oestrogen biosynthetic process", "down regulation of oestrogen biosynthetic process", "downregulation of estrogen biosynthetic process", "negative regulation of estrogen synthesis", "downregulation of estrogen formation", "down regulation of estrogen biosynthetic process", "down regulation of estrogen synthesis"], "types": ["T044"], "canonical_name": "negative regulation of estrogen biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:24530842]"}
{"concept_id": "C3896020", "aliases": ["inhibition of estrogen formation", "inhibition of estrogen synthesis"], "types": ["T044"], "canonical_name": "inhibition of estrogen anabolism"}
{"concept_id": "C3896021", "aliases": ["inhibition of oestrogen biosynthesis"], "types": ["T044"], "canonical_name": "inhibition of estrogen biosynthesis"}
{"concept_id": "C3896022", "aliases": ["inhibition of oestrogen biosynthetic process"], "types": ["T044"], "canonical_name": "inhibition of estrogen biosynthetic process"}
{"concept_id": "C3896023", "aliases": ["upregulation of oestrogen biosynthesis", "up-regulation of oestrogen biosynthetic process", "positive regulation of estrogen synthesis", "up-regulation of oestrogen biosynthesis", "up regulation of estrogen biosynthesis", "up-regulation of estrogen synthesis", "positive regulation of oestrogen biosynthetic process", "up regulation of estrogen formation", "upregulation of oestrogen biosynthetic process", "positive regulation of estrogen biosynthesis", "upregulation of estrogen biosynthetic process", "up-regulation of estrogen biosynthetic process", "positive regulation of estrogen formation", "up regulation of oestrogen biosynthetic process", "up regulation of estrogen synthesis", "upregulation of estrogen biosynthesis", "upregulation of estrogen synthesis", "upregulation of estrogen formation", "positive regulation of oestrogen biosynthesis", "up regulation of oestrogen biosynthesis", "up-regulation of estrogen biosynthesis", "up-regulation of estrogen formation", "up regulation of estrogen anabolism", "up-regulation of estrogen anabolism", "upregulation of estrogen anabolism", "positive regulation of estrogen anabolism", "up regulation of estrogen biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of estrogen biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of estrogen biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:24530842]"}
{"concept_id": "C3896024", "aliases": ["activation of estrogen synthesis", "activation of estrogen formation"], "types": ["T044"], "canonical_name": "activation of estrogen anabolism"}
{"concept_id": "C3896025", "aliases": ["activation of oestrogen biosynthetic process", "activation of estrogen biosynthetic process", "activation of oestrogen biosynthesis"], "types": ["T044"], "canonical_name": "activation of estrogen biosynthesis"}
{"concept_id": "C3896074", "aliases": ["up-regulation of transcription from RNA polymerase II promoter involved in neuron differentiation", "up regulation of transcription from RNA polymerase II promoter involved in neuron differentiation", "stimulation of transcription from RNA polymerase II promoter involved in neuron differentiation", "upregulation of transcription from RNA polymerase II promoter involved in neuron differentiation", "positive regulation of transcription from Pol II promoter involved in neuron differentiation", "activation of transcription from RNA polymerase II promoter involved in neuron differentiation"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation", "definition": "Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron differentiation. [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:24353061]"}
{"concept_id": "C3896075", "aliases": [], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter involved in neuron differentiation"}
{"concept_id": "C3896076", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron differentiation"}
{"concept_id": "C3896077", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of global transcription from Pol II promoter involved in neuron differentiation"}
{"concept_id": "C3896078", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron differentiation"}
{"concept_id": "C3896079", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter involved in neuron differentiation"}
{"concept_id": "C3896080", "aliases": ["upregulation of global transcription from RNA polymerase II promoter involved in neuron differentiation", "up-regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation"], "types": ["T045"], "canonical_name": "up regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation"}
{"concept_id": "C3896081", "aliases": [], "types": ["T043"], "canonical_name": "pyrimidine nucleobase transmembrane transport", "definition": "The process in which pyrimidine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie]"}
{"concept_id": "C3896087", "aliases": [], "types": ["T039"], "canonical_name": "regulation of epiboly involved in gastrulation with mouth forming second", "definition": "Any process that modulates the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second. [GO_REF:0000058, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C3896088", "aliases": ["downregulation of epiboly involved in gastrulation with mouth forming second", "down regulation of epiboly involved in gastrulation with mouth forming second", "down-regulation of epiboly involved in gastrulation with mouth forming second"], "types": ["T039"], "canonical_name": "negative regulation of epiboly involved in gastrulation with mouth forming second", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second. [GO_REF:0000058, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C3896089", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of epiboly involved in gastrulation with mouth forming second"}
{"concept_id": "C3896090", "aliases": ["upregulation of epiboly involved in gastrulation with mouth forming second", "up regulation of epiboly involved in gastrulation with mouth forming second", "up-regulation of epiboly involved in gastrulation with mouth forming second"], "types": ["T039"], "canonical_name": "positive regulation of epiboly involved in gastrulation with mouth forming second", "definition": "Any process that activates or increases the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second. [GO_REF:0000058, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C3896091", "aliases": [], "types": ["T039"], "canonical_name": "activation of epiboly involved in gastrulation with mouth forming second"}
{"concept_id": "C3896092", "aliases": ["negative regulation of programmed cell death, neurons by negative regulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of neuron apoptotic process by negative regulation of transcription from RNA polymerase II promoter", "definition": "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of neuron apoptotic process. [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:20150917]"}
{"concept_id": "C3896093", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of neuron apoptosis by negative regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C3896094", "aliases": ["Cathepsin-B - cystatin-A complex location"], "types": ["T026"], "canonical_name": "Cathepsin-B - cystatin-A complex"}
{"concept_id": "C3896095", "aliases": ["oligopeptide binding involved in non-ribosomal peptide biosynthetic process", "oligopeptide binding involved in nonribosomal peptide biosynthetic process", "oligopeptide binding involved in nonribosomal peptide anabolism", "oligopeptide binding involved in non-ribosomal peptide formation", "oligopeptides binding involved in nonribosomal peptide anabolism", "peptidyl binding involved in nonribosomal peptide biosynthesis", "peptidyl carrier protein activity", "peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis", "oligopeptides binding involved in nonribosomal peptide biosynthesis", "oligopeptide binding involved in nonribosomal peptide synthesis", "oligopeptides binding involved in nonribosomal peptide formation", "oligopeptides binding involved in nonribosomal peptide synthesis", "oligopeptides binding involved in non-ribosomal peptide biosynthesis", "oligopeptide binding involved in non-ribosomal peptide synthesis", "PCP", "peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process", "oligopeptides binding involved in nonribosomal peptide biosynthetic process", "oligopeptide binding involved in non-ribosomal peptide biosynthesis", "peptidyl binding involved in nonribosomal peptide biosynthetic process", "oligopeptide binding involved in nonribosomal peptide biosynthesis", "oligopeptides binding involved in non-ribosomal peptide formation", "oligopeptides binding involved in non-ribosomal peptide synthesis", "oligopeptide binding involved in nonribosomal peptide formation"], "types": ["T044"], "definition": "Binding an amino-acid derived peptidyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the peptidyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. Peptidyl carrier protein (PCP) is involved in nonribosomal peptide biosynthetic process. [GO_REF:0000061, GOC:pr, GOC:TermGenie, GOC:vw, PMID:17502372]", "canonical_name": "oligopeptides binding involved in non-ribosomal peptide biosynthetic process"}
{"concept_id": "C3896096", "aliases": ["Oligopeptid binding involved in non-ribosomal peptide synthesis", "oligopeptido binding involved in nonribosomal peptide formation", "Oligopeptid binding involved in non-ribosomal peptide formation", "oligopeptido binding involved in nonribosomal peptide anabolism", "Oligopeptid binding involved in nonribosomal peptide anabolism", "oligopeptido binding involved in nonribosomal peptide synthetase", "Oligopeptid binding involved in nonribosomal peptide biosynthetic process", "oligopeptido binding involved in nonribosomal peptide biosynthetic process", "Oligopeptid binding involved in nonribosomal peptide formation", "Oligopeptid binding involved in non-ribosomal peptide biosynthetic process", "oligopeptido binding involved in nonribosomal peptide biosynthesis", "Oligopeptid binding involved in nonribosomal peptide synthesis", "oligopeptido binding involved in non-ribosomal peptide synthesis", "Oligopeptid binding involved in nonribosomal peptide biosynthesis", "oligopeptido binding involved in non-ribosomal peptide biosynthesis", "oligopeptido binding involved in non-ribosomal peptide biosynthetic process", "oligopeptido binding involved in nonribosomal peptide synthesis", "Oligopeptid binding involved in nonribosomal peptide synthetase", "oligopeptido binding involved in non-ribosomal peptide formation"], "types": ["T044"], "canonical_name": "Oligopeptid binding involved in non-ribosomal peptide biosynthesis"}
{"concept_id": "C3896097", "aliases": ["oligopeptides binding involved in nonribosomal peptide synthetase"], "types": ["T044"], "canonical_name": "oligopeptide binding involved in nonribosomal peptide synthetase"}
{"concept_id": "C3896098", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl carrier protein"}
{"concept_id": "C3896099", "aliases": ["regulation of autophagic death", "regulation of programmed cell death by autophagy"], "types": ["T043"], "canonical_name": "regulation of autophagic cell death", "definition": "Any process that modulates the frequency, rate or extent of autophagic cell death. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]"}
{"concept_id": "C3896101", "aliases": [], "types": ["T043"], "canonical_name": "regulation of programmed cell death by macroautophagy"}
{"concept_id": "C3896102", "aliases": [], "types": ["T043"], "canonical_name": "regulation of type II programmed cell death"}
{"concept_id": "C3896103", "aliases": ["negative regulation of programmed cell death by macroautophagy", "down-regulation of autophagic cell death", "down regulation of autophagic cell death", "downregulation of programmed cell death by macroautophagy", "down regulation of programmed cell death by macroautophagy", "downregulation of autophagic cell death", "down-regulation of programmed cell death by macroautophagy"], "types": ["T043"], "canonical_name": "negative regulation of autophagic cell death", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]"}
{"concept_id": "C3896104", "aliases": ["negative regulation of type II programmed cell death", "down-regulation of type II programmed cell death", "downregulation of type II programmed cell death"], "types": ["T043"], "canonical_name": "down regulation of type II programmed cell death"}
{"concept_id": "C3896105", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of autophagic cell death"}
{"concept_id": "C3896106", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of programmed cell death by macroautophagy"}
{"concept_id": "C3896107", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of type II programmed cell death"}
{"concept_id": "C3896108", "aliases": ["upregulation of autophagic cell death", "up regulation of autophagic cell death", "up-regulation of autophagic cell death"], "types": ["T043"], "canonical_name": "positive regulation of autophagic cell death", "definition": "Any process that activates or increases the frequency, rate or extent of autophagic cell death. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]"}
{"concept_id": "C3896109", "aliases": [], "types": ["T043"], "canonical_name": "activation of autophagic cell death"}
{"concept_id": "C3896110", "aliases": [], "types": ["T043"], "canonical_name": "activation of programmed cell death by macroautophagy"}
{"concept_id": "C3896111", "aliases": [], "types": ["T043"], "canonical_name": "activation of type II programmed cell death"}
{"concept_id": "C3896112", "aliases": ["up-regulation of programmed cell death by macroautophagy", "up regulation of programmed cell death by macroautophagy", "upregulation of programmed cell death by macroautophagy"], "types": ["T043"], "canonical_name": "positive regulation of programmed cell death by macroautophagy"}
{"concept_id": "C3896113", "aliases": ["upregulation of type II programmed cell death", "up regulation of type II programmed cell death", "up-regulation of type II programmed cell death"], "types": ["T043"], "canonical_name": "positive regulation of type II programmed cell death"}
{"concept_id": "C3896114", "aliases": ["down-regulation of endosperm development", "downregulation of endosperm development", "down regulation of endosperm development"], "types": ["T039"], "canonical_name": "negative regulation of endosperm development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endosperm development. [GO_REF:0000058, GOC:TermGenie, PMID:25194028]"}
{"concept_id": "C3896115", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of endosperm development"}
{"concept_id": "C3896116", "aliases": ["protein tyrosine phosphatase complex location"], "types": ["T026"], "canonical_name": "protein tyrosine phosphatase complex", "definition": "A protein complex which is capable of protein tyrosine phosphatase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22389722]"}
{"concept_id": "C3896117", "aliases": ["acid phosphatase complex location"], "types": ["T026"], "canonical_name": "acid phosphatase complex", "definition": "A protein complex which is capable of acid phosphatase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:8132635]"}
{"concept_id": "C3896118", "aliases": ["regulation of protein amino acid O-linked glycosylation"], "types": ["T040"], "canonical_name": "regulation of protein O-linked glycosylation", "definition": "Any process that modulates the frequency, rate or extent of protein O-linked glycosylation. [GO_REF:0000058, GOC:TermGenie, PMID:24509081]"}
{"concept_id": "C3896119", "aliases": ["down-regulation of protein amino acid O-linked glycosylation", "downregulation of protein O-linked glycosylation", "down-regulation of protein O-linked glycosylation", "downregulation of protein amino acid O-linked glycosylation", "down regulation of protein O-linked glycosylation", "negative regulation of protein amino acid O-linked glycosylation", "down regulation of protein amino acid O-linked glycosylation"], "types": ["T044"], "canonical_name": "negative regulation of protein O-linked glycosylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation. [GO_REF:0000058, GOC:TermGenie, PMID:24509081]"}
{"concept_id": "C3896120", "aliases": ["inhibition of protein amino acid O-linked glycosylation"], "types": ["T044"], "canonical_name": "inhibition of protein O-linked glycosylation"}
{"concept_id": "C3896121", "aliases": ["upregulation of protein amino acid O-linked glycosylation", "upregulation of protein O-linked glycosylation", "up-regulation of protein O-linked glycosylation", "positive regulation of protein amino acid O-linked glycosylation", "up regulation of protein amino acid O-linked glycosylation", "up regulation of protein O-linked glycosylation", "up-regulation of protein amino acid O-linked glycosylation"], "types": ["T040"], "canonical_name": "positive regulation of protein O-linked glycosylation", "definition": "Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation. [GO_REF:0000058, GOC:TermGenie, PMID:24509081]"}
{"concept_id": "C3896122", "aliases": ["activation of protein amino acid O-linked glycosylation"], "types": ["T040"], "canonical_name": "activation of protein O-linked glycosylation"}
{"concept_id": "C3896123", "aliases": [], "types": ["T043"], "canonical_name": "response to acadesine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119]"}
{"concept_id": "C3896124", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to acadesine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119]"}
{"concept_id": "C3896125", "aliases": [], "types": ["T039"], "canonical_name": "regulation of convergent extension involved in gastrulation", "definition": "Any process that modulates the frequency, rate or extent of convergent extension involved in gastrulation. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C3896126", "aliases": ["downregulation of convergent extension involved in gastrulation", "down regulation of convergent extension involved in gastrulation", "down-regulation of convergent extension involved in gastrulation"], "types": ["T039"], "canonical_name": "negative regulation of convergent extension involved in gastrulation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in gastrulation. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C3896127", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of convergent extension involved in gastrulation"}
{"concept_id": "C3896128", "aliases": ["up-regulation of convergent extension involved in gastrulation", "upregulation of convergent extension involved in gastrulation", "up regulation of convergent extension involved in gastrulation"], "types": ["T039"], "canonical_name": "positive regulation of convergent extension involved in gastrulation", "definition": "Any process that activates or increases the frequency, rate or extent of convergent extension involved in gastrulation. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C3896129", "aliases": [], "types": ["T039"], "canonical_name": "activation of convergent extension involved in gastrulation"}
{"concept_id": "C3896130", "aliases": ["protein localisation in microvillus", "protein localisation to microvillus", "protein localization in microvillus"], "types": ["T043"], "canonical_name": "protein localization to microvillus", "definition": "A process in which a protein is transported to, or maintained in, a location within a microvillus. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]"}
{"concept_id": "C3896131", "aliases": ["protein localization in microvillus membrane", "protein localisation in microvillus membrane", "protein localisation to microvillus membrane"], "types": ["T043"], "canonical_name": "protein localization to microvillus membrane", "definition": "A process in which a protein is transported to, or maintained in, a location within a microvillus membrane. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]"}
{"concept_id": "C3896132", "aliases": ["protein localisation in ciliary inversin compartment", "protein localisation to ciliary inversin compartment", "protein localization in ciliary inversin compartment"], "types": ["T043"], "canonical_name": "protein localization to ciliary inversin compartment", "definition": "A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]"}
{"concept_id": "C3896133", "aliases": ["up regulation of cholesterol import", "upregulation of cholesterol uptake", "up-regulation of cholesterol import", "positive regulation of cholesterol uptake", "up regulation of cholesterol uptake", "up-regulation of cholesterol uptake", "upregulation of cholesterol import"], "types": ["T044"], "canonical_name": "positive regulation of cholesterol import", "definition": "Any process that activates or increases the frequency, rate or extent of cholesterol import. [GO_REF:0000058, GOC:TermGenie, PMID:16772292]"}
{"concept_id": "C3896134", "aliases": ["activation of cholesterol uptake"], "types": ["T044"], "canonical_name": "activation of cholesterol import"}
{"concept_id": "C3896137", "aliases": ["deubiquitinase binding", "deubiquitinating enzyme binding"], "types": ["T044"], "canonical_name": "ubiquitin-specific protease binding", "definition": "Binding to a ubiquitin-specific protease. [GOC:bf, GOC:PARL, PMID:24063750]"}
{"concept_id": "C3896140", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to biotin starvation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin. [PMID:12557275]"}
{"concept_id": "C3896141", "aliases": [], "types": ["T042"], "canonical_name": "hyaloid vascular plexus regression", "definition": "The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression. [GOC:hjd, PMID:18841878]"}
{"concept_id": "C3896142", "aliases": [], "types": ["T026"], "canonical_name": "meiotic spindle midzone", "definition": "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap. [GOC:kmv, PMID:12707312]"}
{"concept_id": "C3896143", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cleavage furrow ingression", "definition": "Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed. [GOC:kmv, PMID:12707312]"}
{"concept_id": "C3896144", "aliases": [], "types": ["T044"], "canonical_name": "isogloboside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a lactosyl-ceramide derivative in which a galactose is linked to the galactose via an alpha 1,3 linkage (vs alpha 1,4 for globosides). [GOC:hjd, PMID:22875802]"}
{"concept_id": "C3896145", "aliases": [], "types": ["T043"], "canonical_name": "xylem-to-phloem iron transport", "definition": "The directed movement of iron ions into the phloem from the xylem. [GOC:tb, PMID:24867923]"}
{"concept_id": "C3896146", "aliases": ["CUE1-UBC7 ubiquitin-conjugating enzyme (E2)", "CUE1-UBC7 ubiquitin-conjugating enzyme complex location"], "types": ["T026"], "canonical_name": "CUE1-UBC7 ubiquitin-conjugating enzyme complex", "definition": "A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1. [GOC:bhm, PMID:23028185]"}
{"concept_id": "C3896147", "aliases": [], "types": ["T044"], "canonical_name": "protein K33-linked ubiquitination", "definition": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is added to a protein. [PMID:24768539]"}
{"concept_id": "C3896148", "aliases": ["DNA damage repair complex location", "DNA damage repair complex", "DNA repair complex location"], "types": ["T026"], "canonical_name": "DNA repair complex", "definition": "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350]"}
{"concept_id": "C3896149", "aliases": ["EFF-1 complex location"], "types": ["T026"], "canonical_name": "EFF-1 complex", "definition": "A trimeric cell-cell fusion complex that serves as a scaffold for zippering up the extracellular domains, bringing the transmembrane segments into close proximity such that they can continue zippering within the two membranes into one. Two prefusion monomers cluster at the surface of adjacent cells. Parallel EFF-1 interactions occur across cells and a third monomer, which can come from either cell, adds on to make an intermediate, extended trimer. [GOC:bhm, PMID:24725407]"}
{"concept_id": "C3896150", "aliases": ["3M complex location"], "types": ["T026"], "canonical_name": "3M complex", "definition": "A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity. [PMID:24793695, PMID:24793696]"}
{"concept_id": "C3896151", "aliases": [], "types": ["T039"], "canonical_name": "cellular response to cell wall damage", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell wall damage. The process begins with detection of the damage and ends with a change in state or activity of the cell. [PMID:17287531]"}
{"concept_id": "C3896152", "aliases": [], "types": ["T043"], "canonical_name": "meiotic spindle pole body organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the meiotic spindle pole body. [GOC:vw]"}
{"concept_id": "C3896153", "aliases": [], "types": ["T045"], "canonical_name": "single-strand break repair via homologous recombination", "definition": "The error-free repair of a single-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. [GOC:bhm, PMID:24339919]"}
{"concept_id": "C3896154", "aliases": [], "types": ["T044"], "canonical_name": "queuosine salvage", "definition": "Any process which produces queuosine from derivatives of it, without de novo synthesis. [GOC:vw, PMID:24911101]"}
{"concept_id": "C3896155", "aliases": ["Cus cation efflux system", "Cus cation efflux complex location"], "types": ["T026"], "canonical_name": "Cus cation efflux complex", "definition": "Transmembrane complex that mediates resistance to copper and silver by cation efflux directly from the cell using the proton-motive force. Spans the inner membrane, periplasm, and outer membrane. Primarily activated under anaerobic conditions by CusR and CusS but also expressed under extreme copper stress, in aerobic growth. [GOC:bhm, PMID:23122209]"}
{"concept_id": "C3896156", "aliases": ["copper efflux complex location"], "types": ["T026"], "canonical_name": "copper efflux complex"}
{"concept_id": "C3896157", "aliases": [], "types": ["T026"], "canonical_name": "copper efflux system"}
{"concept_id": "C3896158", "aliases": ["silver efflux complex location"], "types": ["T026"], "canonical_name": "silver efflux complex"}
{"concept_id": "C3896159", "aliases": [], "types": ["T026"], "canonical_name": "silver efflux system"}
{"concept_id": "C3896160", "aliases": ["regeneration of epithelium"], "types": ["T042"], "canonical_name": "epithelium regeneration", "definition": "The regrowth of lost or destroyed epithelium. [GOC:sl, PMID:19845688]"}
{"concept_id": "C3896161", "aliases": ["mitochondrial LSU rRNA binding"], "types": ["T045"], "canonical_name": "mitochondrial ribosomal large subunit rRNA binding", "definition": "Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA). [PMID:24206665]"}
{"concept_id": "C3896162", "aliases": [], "types": ["T045"], "canonical_name": "21S rRNA binding"}
{"concept_id": "C3896163", "aliases": [], "types": ["T042"], "canonical_name": "embryonic lung development", "definition": "The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure. [PMID:24785085]"}
{"concept_id": "C3896164", "aliases": [], "types": ["T042"], "canonical_name": "embryonic liver development", "definition": "The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure. [PMID:15918910]"}
{"concept_id": "C3896165", "aliases": [], "types": ["T042"], "canonical_name": "embryonic brain development", "definition": "The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure. [PMID:15918910]"}
{"concept_id": "C3896166", "aliases": ["protein ADP-ribosylase activity"], "types": ["T044"], "canonical_name": "NAD+-protein ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243]"}
{"concept_id": "C3896167", "aliases": [], "types": ["T044"], "canonical_name": "ribosylase activity"}
{"concept_id": "C3896168", "aliases": [], "types": ["T044"], "canonical_name": "protein antigen binding", "definition": "Binding to a protein antigen. [PMID:9360996]"}
{"concept_id": "C3896169", "aliases": ["calcitonin gene-related polypeptide receptor complex location", "CGRP-R complex location", "Calcitonin-gene-related peptide receptor complex", "calcitonin gene-related polypeptide receptor complex", "CGRP receptor complex location", "Calcitonin-gene-related peptide receptor complex location", "CGRP-R complex"], "types": ["T026"], "canonical_name": "CGRP receptor complex", "definition": "A transmembrane, G protein-coupled signalling receptor complex recognized by calcitonin gene-related peptides (CGRP). [GOC:bhm, PMID:20826335]"}
{"concept_id": "C3896170", "aliases": ["calcitonin-gene-related polypeptide binding", "CGRP polypeptide binding", "calcitonin-gene-related peptide binding"], "types": ["T044"], "canonical_name": "calcitonin gene-related peptide binding", "definition": "Binding to calcitonin gene-related peptide (CGRP). [GOC:bhm, PMID:10882736]"}
{"concept_id": "C3896171", "aliases": ["calcitonin-gene-related peptide receptor signaling pathway", "CGRP receptor signaling pathway", "calcitonin-gene-related polypeptide receptor signaling pathway"], "types": ["T044"], "canonical_name": "calcitonin gene-related peptide receptor signaling pathway", "definition": "The series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers. [GOC:bhm, PMID:10882736]"}
{"concept_id": "C3896172", "aliases": ["adrenomedullin binding"], "types": ["T044"], "definition": "Binding to adrenomedullin (AM). [GOC:bhm, PMID:10882736]", "canonical_name": "AM binding"}
{"concept_id": "C3896173", "aliases": ["AM receptor signaling pathway"], "types": ["T044"], "canonical_name": "adrenomedullin receptor signaling pathway", "definition": "The series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell. [GOC:bhm, PMID:10882736]"}
{"concept_id": "C3896174", "aliases": [], "types": ["T044"], "canonical_name": "hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)", "definition": "Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium. [PMID:24828577]"}
{"concept_id": "C3896175", "aliases": [], "types": ["T044"], "canonical_name": "hercynylselenocysteine lyase activity (selenoneine-forming)", "definition": "Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium. [PMID:24828577]"}
{"concept_id": "C3896176", "aliases": ["replication-born DSB repair by SCE"], "types": ["T045"], "canonical_name": "replication-born double-strand break repair via sister chromatid exchange", "definition": "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks. [GOC:rb, PMID:12820977, PMID:16888651]"}
{"concept_id": "C3896178", "aliases": ["cellular response to BDNF stimulus"], "types": ["T043"], "canonical_name": "cellular response to brain-derived neurotrophic factor stimulus", "definition": "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus. [PMID:21958434]"}
{"concept_id": "C3896179", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA release from pre-rRNA", "definition": "The release of snoRNA from pre-rRNA. [GOC:rb, PMID:16908538]"}
{"concept_id": "C3896180", "aliases": [], "types": ["T043"], "canonical_name": "response to insulin-like growth factor stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus. [PMID:21932665]"}
{"concept_id": "C3896182", "aliases": ["establishment of SIN asymmetry"], "types": ["T043"], "canonical_name": "establishment of septation initiation network asymmetry", "definition": "The septation initiation signaling process by which the activity of the septation initiation network (SIN) is activated asymmetrically on the spindle pole bodies. [PMID:22786806]"}
{"concept_id": "C3896184", "aliases": [], "types": ["T044"], "canonical_name": "glyoxalase (glycolic acid-forming) activity", "definition": "Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor. [GOC:bf, GOC:PARL, PMID:22523093]"}
{"concept_id": "C3896185", "aliases": ["Rod-Zwilch-Zw10 complex", "RZZ complex location", "Rod-Zwilch-Zw10 complex location"], "types": ["T026"], "canonical_name": "RZZ complex", "definition": "A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints. [PMID:12686595, PMID:15922598, PMID:20462495]"}
{"concept_id": "C3896186", "aliases": [], "types": ["T044"], "canonical_name": "protein arginine kinase activity", "definition": "Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate. [GOC:imk, PMID:22517742]"}
{"concept_id": "C3896187", "aliases": ["homologous recombination-dependent replication fork processing", "mitotic recombination involved in recovery from replication fork arrest", "mitotic recombination involved in recovery from replication fork stalling", "mitotic recombination involved in collapsed replication fork processing"], "types": ["T045"], "canonical_name": "mitotic recombination-dependent replication fork processing", "definition": "Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart. [GOC:mah, PMID:23093942]"}
{"concept_id": "C3896188", "aliases": [], "types": ["T045"], "canonical_name": "homologous recombination dependent replication fork recovery"}
{"concept_id": "C3896189", "aliases": [], "types": ["T026"], "canonical_name": "stereocilia tip-link density", "definition": "An electron-dense plaque at either end of a stereocilia tip link that provides the anchor in the stereocilia membrane. [PMID:19447093, PMID:21709241]"}
{"concept_id": "C3896190", "aliases": ["microRNA transport"], "types": ["T043"], "canonical_name": "miRNA transport", "definition": "The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. [GO:jl, PMID:24356509]"}
{"concept_id": "C3896191", "aliases": ["peroxisomal import pore", "peroxisomal protein import machinery", "peroxisomal importomer complex location"], "types": ["T026"], "canonical_name": "peroxisomal importomer complex", "definition": "A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners. [PMID:12667447, PMID:20154681, PMID:22375831]"}
{"concept_id": "C3896192", "aliases": ["Pex14 complex location"], "types": ["T026"], "canonical_name": "Pex14 complex"}
{"concept_id": "C3896193", "aliases": [], "types": ["T044"], "canonical_name": "extracellular matrix protein binding", "definition": "Binding to a protein that is part of an extracellular matrix. [PMID:22355679]"}
{"concept_id": "C3896194", "aliases": ["priRNA 3' end processing", "primal small RNA 3'-end processing"], "types": ["T045"], "canonical_name": "priRNA 3'-end processing", "definition": "The process of forming the mature 3' end of a priRNA molecule. [PMID:24095277]"}
{"concept_id": "C3896195", "aliases": ["siRNA 3' end processing", "small interfering RNA 3'-end processing"], "types": ["T045"], "canonical_name": "siRNA 3'-end processing", "definition": "The process of forming the mature 3' end of a siRNA molecule. [PMID:24095277]"}
{"concept_id": "C3896196", "aliases": ["CSL-NotchIC-MASTERMIND complex", "CSL-Notch-Mastermind transcription factor complex location", "CSL-NotchIC-MASTERMIND complex location"], "types": ["T026"], "canonical_name": "CSL-Notch-Mastermind transcription factor complex", "definition": "A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes. [GOC:bhm, GOC:dos, PMID:16530045]"}
{"concept_id": "C3896197", "aliases": ["LTLD"], "types": ["T026"], "canonical_name": "lower tip-link density", "definition": "An electron-dense plaque at the lower end of a stereocilia tip link that provides the anchor in the stereocilia membrane at the tip of the stereocilium from which the tip link rises. [PMID:19447093]"}
{"concept_id": "C3896198", "aliases": ["UTLD"], "types": ["T026"], "canonical_name": "upper tip-link density", "definition": "An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends. [PMID:19447093]"}
{"concept_id": "C3896200", "aliases": [], "types": ["T045"], "canonical_name": "snRNA 2'-O-methylation", "definition": "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an snRNA molecule. [PMID:11842100, PMID:9844635]"}
{"concept_id": "C3896201", "aliases": [], "types": ["T045"], "canonical_name": "U6 2'-O-snRNA methylation", "definition": "The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule. [PMID:11842100, PMID:9844635]"}
{"concept_id": "C3896202", "aliases": [], "types": ["T044"], "canonical_name": "MAP kinase serine/threonine phosphatase activity", "definition": "Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate. [PMID:10398679]"}
{"concept_id": "C3896203", "aliases": ["activation of transcription from RNA polymerase II promoter in response to ER stress", "upregulation of Pol II transcription induced by ER stress", "stimulation of transcription from RNA polymerase II promoter in response to ER stress", "up-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress", "upregulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress"], "types": ["T043"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress", "definition": "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. [GOC:bf, GOC:PARL, PMID:21113145]"}
{"concept_id": "C3896205", "aliases": [], "types": ["T043"], "canonical_name": "ER stress-induced upregulation of transcription"}
{"concept_id": "C3896206", "aliases": [], "types": ["T043"], "canonical_name": "up-regulation of transcription induced by ER stress"}
{"concept_id": "C3896207", "aliases": ["suppression of transcription from RNA polymerase II promoter under ER stress", "repression of transcription from RNA polymerase II promoter under ER stress", "down-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress", "negative regulation of transcription from RNA polymerase II promoter in response to ER stress", "ER stress-induced negative regulation of transcription from RNA polymerase II promoter", "down regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress", "reduction of transcription from RNA polymerase II promoter under ER stress"], "types": ["T043"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. [GOC:bf, GOC:PARL, PMID:21113145]"}
{"concept_id": "C3896208", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress"}
{"concept_id": "C3896209", "aliases": ["nitrosative stress-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "intrinsic apoptotic signaling pathway in response to nitrosative stress", "definition": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. [GOC:bf, GOC:PARL, PMID:23985028]"}
{"concept_id": "C3896210", "aliases": [], "types": ["T043"], "canonical_name": "nitrosative stress-induced apoptosis"}
{"concept_id": "C3896211", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine autophosphorylation", "definition": "The phosphorylation by a protein of one or more of its own threonine amino acid residues, or a threonine residue on an identical protein. [PMID:7803855]"}
{"concept_id": "C3896212", "aliases": [], "types": ["T044"], "canonical_name": "F-box domain binding", "definition": "Binding to an F-box domain of a protein. [GOC:bf, GOC:PARL, InterPro:IPR001810, PMID:12628165]"}
{"concept_id": "C3896213", "aliases": [], "types": ["T044"], "canonical_name": "U1 snRNP binding", "definition": "Binding to a U1 small nuclear ribonucleoprotein particle. [PMID:14713954]"}
{"concept_id": "C3896214", "aliases": [], "types": ["T044"], "canonical_name": "U2 snRNP binding", "definition": "Binding to a U2 small nuclear ribonucleoprotein particle. [PMID:14713954]"}
{"concept_id": "C3896215", "aliases": ["EJC binding"], "types": ["T044"], "canonical_name": "exon-exon junction complex binding", "definition": "Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. [GOC:sart, PMID:24967911]"}
{"concept_id": "C3896222", "aliases": ["M1-linked ubiquitin chain binding"], "types": ["T044"], "canonical_name": "linear polyubiquitin binding", "definition": "Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next. [GOC:bf, GOC:PARL, PMID:23453807]"}
{"concept_id": "C3896223", "aliases": [], "types": ["T043"], "canonical_name": "cellular stress response to acidic pH", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution. [GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049]"}
{"concept_id": "C3896224", "aliases": [], "types": ["T043"], "canonical_name": "cellular stress response to acidity"}
{"concept_id": "C3896225", "aliases": ["Park2-FBXW7-Cul1 complex", "Park2-FBXW7-Cul1 complex location", "PRKN-FBXW7-Cul1 complex", "Parkin-FBXW7-Cul1 protein complex location", "Parkin/Cul1/F-box protein complex", "Parkin-FBXW7-Cul1 ubiquitin ligase complex location", "PRKN-FBXW7-Cul1 complex location", "Parkin-FBXW7-Cul1 protein complex", "Parkin/Cul1/F-box protein complex location"], "types": ["T026"], "canonical_name": "Parkin-FBXW7-Cul1 ubiquitin ligase complex", "definition": "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein. [GOC:bf, GOC:PARL, PMID:12628165]"}
{"concept_id": "C3896226", "aliases": ["Parkin-HSel-10-Cullin-1 complex location"], "types": ["T026"], "canonical_name": "Parkin-HSel-10-Cullin-1 complex"}
{"concept_id": "C3896227", "aliases": ["nucleosome disassembly/reassembly complex location"], "types": ["T026"], "canonical_name": "nucleosome disassembly/reassembly complex", "definition": "A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex. [GOC:bhm, PMID:24843044]"}
{"concept_id": "C3896228", "aliases": ["eaf5/7/3 complex location"], "types": ["T026"], "canonical_name": "eaf5/7/3 complex"}
{"concept_id": "C3896229", "aliases": ["L-type voltage-gated calcium channel complex location"], "types": ["T026"], "canonical_name": "L-type voltage-gated calcium channel complex", "definition": "A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. [GOC:ame, PMID:12946355]"}
{"concept_id": "C3896230", "aliases": ["cardiac muscle L-type voltage-gated calcium channel complex location"], "types": ["T026"], "canonical_name": "cardiac muscle L-type voltage-gated calcium channel complex"}
{"concept_id": "C3896231", "aliases": ["skeletal muscle L-type voltage-gated calcium channel complex location"], "types": ["T026"], "canonical_name": "skeletal muscle L-type voltage-gated calcium channel complex"}
{"concept_id": "C3896232", "aliases": ["mitochondrion-ER tethering", "mitochondrion-ER membrane tethering", "mitochondrion-endoplasmic reticulum tethering", "mitochondrion-ER attachment", "mitochondrion-endoplasmic reticulum attachment"], "types": ["T043"], "canonical_name": "mitochondrion-endoplasmic reticulum membrane tethering", "definition": "The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. [PMID:19556461, PMID:27875684]"}
{"concept_id": "C3896233", "aliases": [], "types": ["T026"], "canonical_name": "pexophagosome", "definition": "A membrane-bounded intracellular vesicle involved in the degradation of peroxisome by macropexophagy. [PMID:22536249]"}
{"concept_id": "C3896234", "aliases": [], "types": ["T044"], "canonical_name": "lipooligosaccharide binding", "definition": "Binding to lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria. [GOC:hjd, PMID:8894399]"}
{"concept_id": "C3896235", "aliases": [], "types": ["T044"], "canonical_name": "LOS binding"}
{"concept_id": "C3896236", "aliases": [], "types": ["T044"], "canonical_name": "transferrin receptor binding", "definition": "Binding to a transferrin receptor. [GOC:pm, PMID:9819414]"}
{"concept_id": "C3896237", "aliases": [], "types": ["T044"], "canonical_name": "leptin receptor binding", "definition": "Binding to a leptin receptor. [GOC:pm, PMID:22405007]"}
{"concept_id": "C3896238", "aliases": [], "types": ["T040"], "canonical_name": "detoxification of iron ion", "definition": "Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion. [GOC:sart, PMID:23064556]"}
{"concept_id": "C3896239", "aliases": [], "types": ["T026"], "canonical_name": "omegasome", "definition": "Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites. [GOC:autophagy, GOC:mf, PMID:18725538, PMID:24591649]"}
{"concept_id": "C3896240", "aliases": ["Skb1-containing cortical node"], "types": ["T026"], "canonical_name": "lateral cortical node", "definition": "A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins. [GOC:mah, PMID:25009287]"}
{"concept_id": "C3896241", "aliases": ["(R)-2-hydroxyacid:quinone oxidoreductase activity"], "types": ["T044"], "canonical_name": "D-2-hydroxyacid dehydrogenase (quinone) activity", "definition": "Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol. [EC:1.1.5.10, GOC:am, PMID:3013300, PMID:4582730]"}
{"concept_id": "C3896242", "aliases": [], "types": ["T044"], "canonical_name": "(R)-2-hydroxy acid dehydrogenase activity"}
{"concept_id": "C3896243", "aliases": ["D-lactate dehydrogenase (quinone) activity"], "types": ["T044"], "canonical_name": "D-lactate dehydrogenase (quinone) activity", "definition": "Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol. [GOC:pz, PMID:10944213, PMID:4575624, RHEA:51468]"}
{"concept_id": "C3896244", "aliases": [], "types": ["T044"], "canonical_name": "D-lactate:quinone oxidoreductase activity"}
{"concept_id": "C3896245", "aliases": [], "types": ["T044"], "canonical_name": "aldehyde oxygenase (deformylating) activity", "definition": "Catalysis of the reaction a long-chain aldehyde + O(2) + 2 NADPH = an alkane + formate + H(2)O + 2 NADP(+). [GOC:mengo_curators, PMID:22947199, RHEA:21440]"}
{"concept_id": "C3896246", "aliases": ["protein self-sumoylation", "protein auto-sumoylation"], "types": ["T044"], "canonical_name": "protein autosumoylation", "definition": "The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [PMID:21518767, PMID:23443663]"}
{"concept_id": "C3896247", "aliases": ["NuA3a histone acetyltransferase complex location"], "types": ["T026"], "canonical_name": "NuA3a histone acetyltransferase complex", "definition": "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p. [GOC:rb, PMID:25104842]"}
{"concept_id": "C3896248", "aliases": ["NuA3b histone acetyltransferase complex location"], "types": ["T026"], "canonical_name": "NuA3b histone acetyltransferase complex", "definition": "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p. [GOC:rb, PMID:25104842]"}
{"concept_id": "C3896249", "aliases": ["rhi-del-cuff complex", "rhi-del-cuff complex location", "RDC complex", "RDC complex location"], "types": ["T026"], "canonical_name": "Rhino-Deadlock-Cutoff Complex", "definition": "Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation. [GOC:bhm, PMID:24906153]"}
{"concept_id": "C3896250", "aliases": [], "types": ["T045"], "canonical_name": "piRNA cluster binding", "definition": "Binding to piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs). [GOC:bhm, PMID:24906153]"}
{"concept_id": "C3896251", "aliases": [], "types": ["T045"], "canonical_name": "piRNA uni-strand cluster binding", "definition": "Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa. [GOC:bhm, PMID:24906153]"}
{"concept_id": "C3896252", "aliases": [], "types": ["T045"], "canonical_name": "piRNA dual-strand cluster binding", "definition": "Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription. [GOC:bhm, PMID:24906153]"}
{"concept_id": "C3896253", "aliases": ["CTS binding"], "types": ["T044"], "canonical_name": "ciliary targeting signal binding", "definition": "Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane. [GOC:krc, PMID:18256283, PMID:19575670, PMID:20603001, PMID:20697559]"}
{"concept_id": "C3896254", "aliases": ["recycling pool of synaptic vesicles"], "types": ["T026"], "canonical_name": "synaptic vesicle, recycling pool", "definition": "A synaptic vesicle belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state. [GOC:pad, PMID:22745285]"}
{"concept_id": "C3896255", "aliases": ["resting pool of synaptic vesicles", "reserve pool of synaptic vesicles"], "types": ["T026"], "canonical_name": "synaptic vesicle, resting pool", "definition": "A synaptic vesicle belonging to the pool that remain unreleased even after prolonged stimulation causes a saturating degree of vesicular turnover. 50-80% of the total number of synaptic vesicles at a resting terminal bouton are in this pool. [GOC:pad, PMID:22745285]"}
{"concept_id": "C3896256", "aliases": ["MTREC complex location", "Mtl1-Red1 core complex location", "NURS complex location", "Mtl1-Red1 core complex", "PAXT complex", "PAXT complex location", "NURS complex"], "types": ["T026"], "canonical_name": "MTREC complex", "definition": "Protein complex formed by an RNA binding protein Red1, an RNA helicase Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2. This complex is required for the recruitment of the nuclear exosome to Mmi1 nuclear focus. It is likely related to the human CBCN complex. This complex is also known as RNA silencing (NURS) complex. [PMID:24210919, PMID:24713849, PMID:32012158]"}
{"concept_id": "C3896257", "aliases": [], "types": ["T040"], "canonical_name": "response to ultrasound", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus. [PMID:20950932]"}
{"concept_id": "C3896260", "aliases": ["mRNA pseudouridylation"], "types": ["T045"], "canonical_name": "mRNA pseudouridine synthesis", "definition": "The intramolecular conversion of uridine to pseudouridine in an mRNA molecule. [PMID:25192136]"}
{"concept_id": "C3896261", "aliases": [], "types": ["T044"], "canonical_name": "sphingolipid alpha-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC. [GOC:tb, PMID:25122154]"}
{"concept_id": "C3896262", "aliases": [], "types": ["T044"], "canonical_name": "inositol phosphorylceramide glucuronosyltransferase activity"}
{"concept_id": "C3896263", "aliases": ["Clr6 histone deacetylase complex I'' location"], "types": ["T026"], "canonical_name": "Clr6 histone deacetylase complex I''", "definition": "A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3. [PMID:25002536]"}
{"concept_id": "C3896264", "aliases": [], "types": ["T044"], "canonical_name": "aerobic lactate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen. [GOC:mengo_curators, PMID:8941775]"}
{"concept_id": "C3896265", "aliases": [], "types": ["T044"], "canonical_name": "aerobic lactic acid catabolic process"}
{"concept_id": "C3896266", "aliases": [], "types": ["T044"], "canonical_name": "anaerobic lactate catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the absence of oxygen. [GOC:mengo_curators, PMID:11133436]"}
{"concept_id": "C3896267", "aliases": [], "types": ["T044"], "canonical_name": "anaerobic lactic acid catabolic process"}
{"concept_id": "C3896268", "aliases": ["anaerobic fatty acid degradation"], "types": ["T044"], "canonical_name": "anaerobic fatty acid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. [GOC:mengo_curators, PMID:17329794]"}
{"concept_id": "C3896269", "aliases": ["anaerobic lignin degradation"], "types": ["T044"], "canonical_name": "anaerobic lignin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units. [DOI:10.1039/C3EE40932E, GOC:mengo_curators]"}
{"concept_id": "C3896270", "aliases": ["anaerobic cellulose degradation"], "types": ["T044"], "canonical_name": "anaerobic cellulose catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen. [GOC:mengo_curators, PMID:8561466]"}
{"concept_id": "C3896271", "aliases": ["anaerobic pectin degradation"], "types": ["T044"], "canonical_name": "anaerobic pectin catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen. [GOC:mengo_curators, PMID:23079077]"}
{"concept_id": "C3896272", "aliases": ["archaeal proton-transporting A-type ATPase complex location"], "types": ["T026"], "canonical_name": "archaeal proton-transporting A-type ATPase complex", "definition": "A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea. [GOC:mengo_curators, PMID:15473999, PMID:24650628]"}
{"concept_id": "C3896273", "aliases": ["A-type ATPase protein complex location"], "types": ["T026"], "canonical_name": "A-type ATPase protein complex"}
{"concept_id": "C3896274", "aliases": ["archaeal A-type ATPase protein complex location"], "types": ["T026"], "canonical_name": "archaeal A-type ATPase protein complex"}
{"concept_id": "C3896275", "aliases": ["methane biosynthesis from methanol and hydrogen", "methanogenesis from methanol and hydrogen"], "types": ["T044"], "canonical_name": "methane biosynthetic process from methanol and hydrogen", "definition": "The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen. [GOC:mengo_curators, PMID:16347126]"}
{"concept_id": "C3896279", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic translation in response to stress", "definition": "Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:vw, PMID:16278445]"}
{"concept_id": "C3896280", "aliases": [], "types": ["T026"], "canonical_name": "mitotic spindle microtubule", "definition": "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole. [GOC:vw]"}
{"concept_id": "C3896281", "aliases": ["Rapsynoid-Inscuteable complex", "raps-insc complex location", "Rapsynoid-Inscuteable complex location", "partner of inscuteable-inscuteable complex", "partner of inscuteable-inscuteable complex location"], "types": ["T026"], "canonical_name": "raps-insc complex", "definition": "Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2). [GOC:bhm, PMID:22171003]"}
{"concept_id": "C3896282", "aliases": ["eif4e-cup complex location", "eukaryotic translation initiation factor 4E-cup complex location", "eukaryotic translation initiation factor 4E-cup complex"], "types": ["T026"], "canonical_name": "eif4e-cup complex", "definition": "A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo. [GOC:bhm, PMID:14723848]"}
{"concept_id": "C3896283", "aliases": ["MGN-RBM8A complex location", "MGN-RBM8A complex", "exon-exon junction subcomplex mago-y14 location", "exon junction subcomplex MAGOH-Y14", "exon junction subcomplex MAGOH-Y14 location"], "types": ["T026"], "canonical_name": "exon-exon junction subcomplex mago-y14", "definition": "Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA. [GOC:bhm, PMID:12730685]"}
{"concept_id": "C3896284", "aliases": ["mago-y14 complex location"], "types": ["T026"], "canonical_name": "mago-y14 complex"}
{"concept_id": "C3896285", "aliases": ["dense core vesicle maturation"], "types": ["T043"], "canonical_name": "dense core granule maturation", "definition": "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. [GOC:kmv, PMID:22654674]"}
{"concept_id": "C3896286", "aliases": ["dense core vesicle exocytosis"], "types": ["T043"], "canonical_name": "dense core granule exocytosis", "definition": "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels. [GOC:kmv, PMID:17553987, PMID:24653208]"}
{"concept_id": "C3896287", "aliases": ["maintenance of fidelity involved in mitotic cell cycle DNA replication", "maintenance of fidelity involved in mitotic DNA replication"], "types": ["T045"], "canonical_name": "mitotic DNA replication maintenance of fidelity", "definition": "Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication. [PMID:19185548]"}
{"concept_id": "C3896288", "aliases": ["mitotic DNA-dependent DNA replication"], "types": ["T043"], "canonical_name": "mitotic DNA-templated DNA replication", "definition": "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle. [PMID:16120966]"}
{"concept_id": "C3896290", "aliases": ["CDK8 kinase module", "SRB8/9/10/11 complex", "SRB8-SRB11 complex location", "SRB8/9/10/11 complex location", "CKM complex location", "SRB8-SRB11 complex"], "types": ["T026"], "canonical_name": "CKM complex", "definition": "Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8. [GOC:bhm, PMID:12200444]"}
{"concept_id": "C3896291", "aliases": ["wibg-mago-tsu complex location", "PYM-mago-RNA-binding protein 8A complex location", "wibg-mago-tsu complex", "PYM-mago-Y14 complex location", "PYM-mago-RNA-binding protein 8A complex"], "types": ["T026"], "canonical_name": "PYM-mago-Y14 complex", "definition": "Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans. [GOC:bhm, PMID:14968132]"}
{"concept_id": "C3896292", "aliases": ["Piwi-associated RNA biosynthetic process"], "types": ["T045"], "canonical_name": "piRNA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. [GOC:kmv, PMID:24696457]"}
{"concept_id": "C3896293", "aliases": ["Cry-Per complex location"], "types": ["T026"], "canonical_name": "Cry-Per complex", "definition": "Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms. [GOC:bhm, PMID:24855952]"}
{"concept_id": "C3896294", "aliases": ["CLOCK/BMAL complex location", "CLOCK-BMAL transcription complex location", "CLOCK/BMAL complex"], "types": ["T026"], "canonical_name": "CLOCK-BMAL transcription complex", "definition": "Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms. [GOC:bhm, PMID:23229515]"}
{"concept_id": "C3896295", "aliases": [], "types": ["T045"], "canonical_name": "5' transitive RNA interference", "definition": "An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA. [GOC:pf, PMID:24369430]"}
{"concept_id": "C3896296", "aliases": [], "types": ["T045"], "canonical_name": "3' transitive RNA interference", "definition": "An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA. [GOC:pf, PMID:24369430]"}
{"concept_id": "C3896297", "aliases": [], "types": ["T045"], "canonical_name": "ribonucleotide excision repair", "definition": "The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase. [PMID:12475934, PMID:22864116]"}
{"concept_id": "C3896299", "aliases": [], "types": ["T045"], "canonical_name": "single-stranded 3'-5' DNA helicase activity", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'. [PMID:25165823]"}
{"concept_id": "C3896300", "aliases": ["mitochondrial pyrimidine nucleotide import"], "types": ["T043"], "canonical_name": "pyrimidine nucleotide import into mitochondrion", "definition": "The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix. [PMID:16194150]"}
{"concept_id": "C3896301", "aliases": ["Cut1-2 complex location", "separase-securin complex location", "Cut1-2 complex"], "types": ["T026"], "canonical_name": "separase-securin complex", "definition": "A protein complex that includes separase (a protease which cleaves cohesin as part of chromosome separation) and securin, a protease inhibitor. Chromosome separation is inhibited until securin is degraded by the Anaphase Promoting Complex (APC). [GOC:dos, GOC:vw, PMID:8978688]"}
{"concept_id": "C3896302", "aliases": [], "types": ["T044"], "canonical_name": "m7G(5')pppN diphosphatase activator activity", "definition": "Binds to and increases the activity of m7G(5')pppN diphosphatase. [PMID:22323607]"}
{"concept_id": "C3896303", "aliases": [], "types": ["T040"], "canonical_name": "tail spike morphogenesis", "definition": "The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death. [GOC:kmv, PMID:17329362, PMID:6684600]"}
{"concept_id": "C3896304", "aliases": ["Baculovirus Inhibitor of apoptosis protein Repeat domain binding"], "types": ["T044"], "canonical_name": "BIR domain binding", "definition": "Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain. [GOC:ha, InterPro:IPR001370]"}
{"concept_id": "C3896305", "aliases": ["Ste12p-Dig1p-Dig2p complex location"], "types": ["T026"], "canonical_name": "Ste12p-Dig1p-Dig2p complex", "definition": "A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae. [GOC:rb, PMID:16782869]"}
{"concept_id": "C3896306", "aliases": ["Tec1p-Ste12p-Dig1p complex location"], "types": ["T026"], "canonical_name": "Tec1p-Ste12p-Dig1p complex", "definition": "A multiprotein complex that is involved in the transcriptional regulation of primarily filamentation genes, but also mating genes, in the yeast S. cerevisiae. [GOC:rb, PMID:16782869]"}
{"concept_id": "C3896307", "aliases": ["Rvs161p-Rvs167p complex location"], "types": ["T026"], "canonical_name": "Rvs161p-Rvs167p complex", "definition": "A protein complex that is involved in endocytosis in the yeast S. cerevisiae. [GOC:rb, PMID:20610658]"}
{"concept_id": "C3896308", "aliases": ["glycosylphosphatidylinositol-mannosyltransferase I complex location"], "types": ["T026"], "canonical_name": "glycosylphosphatidylinositol-mannosyltransferase I complex", "definition": "A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M. [GOC:dph, GOC:rb, PMID:15635094]"}
{"concept_id": "C3896309", "aliases": ["GPI-MT-I complex location", "GPI-MT-I complex"], "types": ["T026"], "canonical_name": "GPI-MT-I complex"}
{"concept_id": "C3896310", "aliases": ["Cdc50p-Drs2p complex location"], "types": ["T026"], "canonical_name": "Cdc50p-Drs2p complex", "definition": "A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome. [GOC:rb, PMID:15090616, PMID:22234261]"}
{"concept_id": "C3896311", "aliases": ["Lem3p-Dnf1p complex location"], "types": ["T026"], "canonical_name": "Lem3p-Dnf1p complex"}
{"concept_id": "C3896312", "aliases": ["response to nickel ion stress", "stress response to nickel", "response to nickel toxicity"], "types": ["T039"], "canonical_name": "stress response to nickel ion", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus. [GOC:kmv, PMID:25330323]"}
{"concept_id": "C3896313", "aliases": ["Dom34:Hbs1 complex", "Dom34:Hbs1 complex location", "Dom34-Hbs1 complex location"], "types": ["T026"], "canonical_name": "Dom34-Hbs1 complex", "definition": "A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay. [GOC:mcc, PMID:20890290, PMID:21102444, PMID:21448132, PMID:22503425]"}
{"concept_id": "C3896314", "aliases": [], "types": ["T044"], "canonical_name": "thermospermine oxidase activity", "definition": "Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine. [PMID:24906355]"}
{"concept_id": "C3896315", "aliases": ["neuron process maintenance", "neuronal cell projection maintenance", "neuron protrusion maintenance"], "types": ["T043"], "canonical_name": "neuron projection maintenance", "definition": "The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:kmv, PMID:25359212]"}
{"concept_id": "C3896316", "aliases": [], "types": ["T043"], "canonical_name": "neurite maintenance"}
{"concept_id": "C3896317", "aliases": [], "types": ["T043"], "canonical_name": "phosphoenolpyruvate transmembrane import into Golgi lumen", "definition": "The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane. [PMID:25195688]"}
{"concept_id": "C3896318", "aliases": [], "types": ["T026"], "canonical_name": "mitotic spindle polar microtubule", "definition": "Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone. [PMID:16079915]"}
{"concept_id": "C3896319", "aliases": [], "types": ["T044"], "canonical_name": "xylan O-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan. [PMID:25141999]"}
{"concept_id": "C3896320", "aliases": ["fructose uptake"], "types": ["T043"], "canonical_name": "fructose import across plasma membrane", "definition": "The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol. [PMID:10735857]"}
{"concept_id": "C3896321", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial manganese ion transmembrane transport", "definition": "The process in which a manganese ion is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:12890866]"}
{"concept_id": "C3896322", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial citrate transmembrane transport", "definition": "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix. [GOC:ai, PMID:20371607]"}
{"concept_id": "C3896323", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial transmembrane transport", "definition": "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. [PMID:20533899]"}
{"concept_id": "C3896324", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial S-adenosyl-L-methionine transmembrane transport", "definition": "The process in which S-adenosyl-L-methionine is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:14609944]"}
{"concept_id": "C3896325", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial ATP transmembrane transport", "definition": "The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:18485069]"}
{"concept_id": "C3896326", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial thiamine pyrophosphate transmembrane transport", "definition": "The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:12411483]"}
{"concept_id": "C3896327", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial tricarboxylic acid transmembrane transport", "definition": "The process in which a tricarboxylic acid is transported across a mitochondrial membrane, into or out of the mitochondrion. [GOC:vw]"}
{"concept_id": "C3896328", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial phosphate ion transmembrane transport", "definition": "The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:9099701]"}
{"concept_id": "C3896329", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial FAD transmembrane transport", "definition": "The process in which FAD is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:14555654]"}
{"concept_id": "C3896330", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial NAD transmembrane transport", "definition": "The process in which NAD is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:16291748]"}
{"concept_id": "C3896331", "aliases": ["mitochondrial 2-oxoglutarate transmembrane transport"], "types": ["T043"], "canonical_name": "mitochondrial alpha-ketoglutarate transmembrane transport", "definition": "The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:11013234, PMID:20371607]"}
{"concept_id": "C3896332", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial 2-oxoadipate transmembrane transport", "definition": "The process in which 2-oxoadipate is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:11013234]"}
{"concept_id": "C3896333", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial 5'-adenylyl sulfate transmembrane transport", "definition": "The process in which 5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:24296033]"}
{"concept_id": "C3896334", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport", "definition": "The process in which 3'-phospho-5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:24296033]"}
{"concept_id": "C3896335", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial oxaloacetate transmembrane transport", "definition": "The process in which oxaloacetate is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:10428783]"}
{"concept_id": "C3896336", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial isopropylmalate transmembrane transport", "definition": "The process in which 2-isopropylmalate(2-) is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:10428783]"}
{"concept_id": "C3896337", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial sulfate transmembrane transport", "definition": "The process in which sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:10428783]"}
{"concept_id": "C3896338", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial malonate(1-) transmembrane transport", "definition": "The process in which malonate(1-) is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:10428783]"}
{"concept_id": "C3896339", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial coenzyme A transmembrane transport", "definition": "The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:11158296]"}
{"concept_id": "C3896342", "aliases": ["syndecan-syntenin-ALIX complex location"], "types": ["T026"], "canonical_name": "syndecan-syntenin-ALIX complex", "definition": "An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery. [GOC:bhm, PMID:22660413]"}
{"concept_id": "C3896343", "aliases": ["extracellular vesicular exosome complex location", "exosome complex location", "exosome complex", "extracellular vesicular exosome complex", "extracellular exosome complex location"], "types": ["T026"], "canonical_name": "extracellular exosome complex", "definition": "A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome. [GOC:bhm, PMID:22660413]"}
{"concept_id": "C3896344", "aliases": [], "types": ["T044"], "canonical_name": "protein polyufmylation", "definition": "Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain. [PMID:25219498]"}
{"concept_id": "C3896345", "aliases": ["HSP90-CDC37 chaperone complex location"], "types": ["T026"], "canonical_name": "HSP90-CDC37 chaperone complex", "definition": "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins. [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624]"}
{"concept_id": "C3896346", "aliases": ["I(KACh) inward rectifier potassium channel complex location"], "types": ["T026"], "canonical_name": "I(KACh) inward rectifier potassium channel complex", "definition": "An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signalling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits. [GOC:ame, PMID:9765280]"}
{"concept_id": "C3896347", "aliases": ["GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex location"], "types": ["T026"], "canonical_name": "GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex"}
{"concept_id": "C3896348", "aliases": ["Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex location"], "types": ["T026"], "canonical_name": "Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex"}
{"concept_id": "C3896349", "aliases": ["muscarinic potassium channel complex location"], "types": ["T026"], "canonical_name": "muscarinic potassium channel complex"}
{"concept_id": "C3896350", "aliases": ["DPS complex location"], "types": ["T026"], "canonical_name": "DPS complex", "definition": "A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22. [PMID:24945319]"}
{"concept_id": "C3896351", "aliases": [], "types": ["T043"], "canonical_name": "UDP-N-acetylglucosamine transmembrane transport", "definition": "The process in which UDP-N-acetylglucosamine is transported across a membrane. [PMID:10788474]"}
{"concept_id": "C3896352", "aliases": [], "types": ["T043"], "canonical_name": "GDP-mannose transmembrane transport", "definition": "The process in which GDP-mannose is transported across a membrane. [PMID:9395539]"}
{"concept_id": "C3896353", "aliases": ["homologous chromosome movement towards spindle pole in meiosis I prometaphase", "centromere clustering during meiosis"], "types": ["T043"], "canonical_name": "meiotic centromere clustering", "definition": "The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I. [PMID:10366596, PMID:9009280]"}
{"concept_id": "C3896354", "aliases": ["telomerase reverse transcriptase:RMRP RNA complex", "TERT-RMRP complex location", "telomerase reverse transcriptase:RMRP RNA complex location"], "types": ["T026"], "canonical_name": "TERT-RMRP complex", "definition": "A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP). [GOC:bf, GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19701182]"}
{"concept_id": "C3896355", "aliases": [], "types": ["T043"], "canonical_name": "potassium ion import across plasma membrane", "definition": "The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]"}
{"concept_id": "C3896356", "aliases": [], "types": ["T026"], "canonical_name": "meiotic spindle astral microtubule", "definition": "Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. [PMID:10366596]"}
{"concept_id": "C3896357", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial L-ornithine transmembrane transport", "definition": "The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:9237680]"}
{"concept_id": "C3896358", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial ornithine transmembrane transport"}
{"concept_id": "C3896359", "aliases": ["G-protein coupled glucose receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled glucose receptor activity", "definition": "Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [PMID:15667320]"}
{"concept_id": "C3896360", "aliases": [], "types": ["T044"], "canonical_name": "C-terminal protein demethylation", "definition": "The removal of a methyl group from the C-terminal amino acid of a protein. [PMID:11060018]"}
{"concept_id": "C3896361", "aliases": ["perinuclear ER membrane"], "types": ["T026"], "canonical_name": "perinuclear endoplasmic reticulum membrane", "definition": "The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. [PMID:25454947]"}
{"concept_id": "C3896362", "aliases": ["serine autophosphorylation in trans", "serine transautophosphorylation"], "types": ["T044"], "canonical_name": "peptidyl-serine trans-autophosphorylation", "definition": "The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer. [GOC:bf, GOC:PARL, PMID:21317875]"}
{"concept_id": "C3896363", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic translational termination", "definition": "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination. [PMID:11570975]"}
{"concept_id": "C3896366", "aliases": [], "types": ["T044"], "canonical_name": "phospholipase D activator activity", "definition": "Increases the activity of the enzyme phospholipase D. [PMID:7972129]"}
{"concept_id": "C3896367", "aliases": ["cardiac Troponin complex location"], "types": ["T026"], "canonical_name": "cardiac Troponin complex", "definition": "A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction. [GOC:ame, PMID:12840750]"}
{"concept_id": "C3896368", "aliases": [], "types": ["T026"], "canonical_name": "cTnC:cTnI:cTnT"}
{"concept_id": "C3896369", "aliases": ["HPAT"], "types": ["T044"], "canonical_name": "hydroxyproline O-arabinosyltransferase activity", "definition": "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline <=> a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+. [EC:2.4.2.-, PMID:24036508]"}
{"concept_id": "C3896370", "aliases": ["divisome complex location"], "types": ["T026"], "canonical_name": "divisome complex", "definition": "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells. [GOC:bhm, PMID:15165235, PMID:21784946]"}
{"concept_id": "C3896371", "aliases": ["FtsQBL complex location", "FtsB-FtsL-FtsQ complex location", "FtsB-FtsL-FtsQ complex"], "types": ["T026"], "canonical_name": "FtsQBL complex", "definition": "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ. [GOC:bhm, PMID:15165235, PMID:21784946]"}
{"concept_id": "C3896372", "aliases": ["FtsB-FtsL complex location", "FtsB-FtsL complex", "FtsBL complex location"], "types": ["T026"], "canonical_name": "FtsBL complex", "definition": "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL. [GOC:bhm, PMID:15165235, PMID:21784946]"}
{"concept_id": "C3896373", "aliases": ["ATF4-CREB1 transcription factor complex location"], "types": ["T026"], "canonical_name": "ATF4-CREB1 transcription factor complex", "definition": "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway. [GOC:bhm, PMID:12871976]"}
{"concept_id": "C3896374", "aliases": ["ATF1-ATF4 transcription factor complex location"], "types": ["T026"], "canonical_name": "ATF1-ATF4 transcription factor complex", "definition": "Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway. [GOC:bhm, PMID:12871976]"}
{"concept_id": "C3896375", "aliases": [], "types": ["T043"], "canonical_name": "asparagine transmembrane import into vacuole", "definition": "The directed movement of asparagine into the vacuole across the vacuolar membrane. [PMID:20388511]"}
{"concept_id": "C3896376", "aliases": [], "types": ["T044"], "canonical_name": "protein K69-linked ufmylation", "definition": "A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein. [PMID:25219498]"}
{"concept_id": "C3896377", "aliases": ["NACA binding", "NAC binding"], "types": ["T044"], "canonical_name": "nascent polypeptide-associated complex binding", "definition": "Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. [PMID:25487825]"}
{"concept_id": "C3896378", "aliases": ["L-talarate dehydratase activity"], "types": ["T044"], "canonical_name": "L-altrarate dehydratase activity", "definition": "Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O. [PMID:17649980]"}
{"concept_id": "C3896379", "aliases": [], "types": ["T044"], "canonical_name": "mast cell secretagogue receptor activity", "definition": "Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells. [GOC:sp, PMID:25517090]"}
{"concept_id": "C3896380", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K4 deacetylation", "definition": "The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone. [PMID:20299449]"}
{"concept_id": "C3896381", "aliases": ["IRE1-DAB2IP complex location", "AIP1-IRE1 complex location", "IRE1-DAB2IP complex"], "types": ["T026"], "canonical_name": "AIP1-IRE1 complex", "definition": "A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein). [GOC:bf, GOC:PARL, PMID:18281285]"}
{"concept_id": "C3896382", "aliases": ["IRE1alpha-AIP1 complex location"], "types": ["T026"], "canonical_name": "IRE1alpha-AIP1 complex"}
{"concept_id": "C3896384", "aliases": [], "types": ["T045"], "canonical_name": "3' overhang single-stranded DNA endodeoxyribonuclease activity", "definition": "Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks. [PMID:25203555]"}
{"concept_id": "C3896385", "aliases": [], "types": ["T044"], "canonical_name": "single-stranded DNA endodeoxyribonuclease activator activity", "definition": "Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity. [PMID:25203555]"}
{"concept_id": "C3896386", "aliases": [], "types": ["T045"], "canonical_name": "5' overhang single-stranded DNA endodeoxyribonuclease activity", "definition": "Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks. [PMID:25203555]"}
{"concept_id": "C3896390", "aliases": ["IRE1-TRAF2-ASK1 complex location"], "types": ["T026"], "canonical_name": "IRE1-TRAF2-ASK1 complex", "definition": "A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K). [GOC:bf, GOC:PARL, PMID:12050113, PMID:23000344]"}
{"concept_id": "C3896391", "aliases": [], "types": ["T045"], "canonical_name": "GU repeat RNA binding", "definition": "Binding to an RNA molecule containing GU repeats. [PMID:20081200]"}
{"concept_id": "C3896392", "aliases": [], "types": ["T044"], "canonical_name": "membrane scission GTPase motor activity", "definition": "Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis. [PMID:11242086, PMID:23530241, PMID:24515348]"}
{"concept_id": "C3896394", "aliases": [], "types": ["T043"], "canonical_name": "mitotic spindle pole body localization to nuclear envelope"}
{"concept_id": "C3896395", "aliases": [], "types": ["T044"], "canonical_name": "glutamate-cysteine ligase regulator activity", "definition": "Binds to and modulates the activity of glutamate-cysteine ligase. [PMID:8103521]"}
{"concept_id": "C3896396", "aliases": [], "types": ["T044"], "canonical_name": "acetolactate synthase regulator activity", "definition": "Binds to and modulates the activity of acetolactate synthase. [PMID:8972574]"}
{"concept_id": "C3896397", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic translational initiation in response to stress", "definition": "Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [PMID:16278445]"}
{"concept_id": "C3896398", "aliases": ["Sad1-Kms1 LINC complex location"], "types": ["T026"], "canonical_name": "Sad1-Kms1 LINC complex", "definition": "A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair. [GOC:vw, PMID:24943839, PMID:24947240]"}
{"concept_id": "C3896400", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial magnesium ion transmembrane transport", "definition": "The process in which a magnesium ion (Mg2+) is transported across a mitochondrial membrane, into or out of the mitochondrion. [GOC:ai, PMID:11254124]"}
{"concept_id": "C3896401", "aliases": ["KFRC complex", "Kelch-containing formin regulatory complex location", "KFRC complex location"], "types": ["T026"], "canonical_name": "Kelch-containing formin regulatory complex", "definition": "A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p. [PMID:24828508]"}
{"concept_id": "C3896402", "aliases": ["Bud14-Kel1-Kel2 complex location"], "types": ["T026"], "canonical_name": "Bud14-Kel1-Kel2 complex"}
{"concept_id": "C3896403", "aliases": ["magnesium ion efflux from mitochondrion"], "types": ["T043"], "canonical_name": "magnesium ion export from mitochondrion", "definition": "The directed movement of magnesium ions out of mitochondrial matrix into the cytosol by means of some agent such as a transporter or pore. [PMID:25585246]"}
{"concept_id": "C3896404", "aliases": ["GADD153-ATF4 complex location", "CHOP/ATF4 complex", "CHOP/ATF4 complex location", "CHOP-ATF4 heterodimer", "CHOP-ATF4 complex location", "CHOP-CREB-2 complex location", "GADD153-ATF4 complex", "ATF4-CHOP heterodimer", "CHOP-CREB-2 complex"], "types": ["T026"], "canonical_name": "CHOP-ATF4 complex", "definition": "A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits. [GOC:bf, GOC:PARL, PMID:18940792]"}
{"concept_id": "C3896407", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K9 deacetylation", "definition": "The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone. [PMID:25002536]"}
{"concept_id": "C3896408", "aliases": ["ANPR-A receptor complex location"], "types": ["T026"], "canonical_name": "ANPR-A receptor complex", "definition": "A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. [GOC:ame, PMID:15117952]"}
{"concept_id": "C3896409", "aliases": ["NPR1 receptor complex location"], "types": ["T026"], "canonical_name": "NPR1 receptor complex"}
{"concept_id": "C3896410", "aliases": ["Vps4-Vta1 complex location", "Vta1-Vps4 complex", "Vta1-Vps4 complex location"], "types": ["T026"], "canonical_name": "Vps4-Vta1 complex"}
{"concept_id": "C3896411", "aliases": ["Vps4 complex location", "VPS4 complex", "VPS4 complex location"], "types": ["T026"], "canonical_name": "Vps4 complex"}
{"concept_id": "C3896412", "aliases": ["CHOP-ATF3 heterodimeric complex location", "GADD153-ATF3 complex location", "CHOP-ATF3 heterodimeric complex", "GADD153-ATF3 complex", "ATF3-CHOP complex location", "ATF3-CHOP complex", "CHOP-ATF3 heterodimer", "CHOP-ATF3 complex location"], "types": ["T026"], "canonical_name": "CHOP-ATF3 complex", "definition": "A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits. [GOC:bf, GOC:PARL, PMID:8622660]"}
{"concept_id": "C3896413", "aliases": [], "types": ["T044"], "canonical_name": "guanyl nucleotide exchange factor inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor. [GOC:vw, PMID:25635048]"}
{"concept_id": "C3896414", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of cytoplasmic translational initiation in response to stress", "definition": "Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress. [GOC:vw, PMID:12242291]"}
{"concept_id": "C3896415", "aliases": ["mitochondrion outer membrane fusion"], "types": ["T043"], "canonical_name": "mitochondrial outer membrane fusion", "definition": "The membrane organization process that joins two mitochondrial outer membranes to form a single membrane. [GOC:vw, PMID:21385840]"}
{"concept_id": "C3896416", "aliases": ["mitochondrion inner membrane fusion"], "types": ["T043"], "canonical_name": "mitochondrial inner membrane fusion", "definition": "The membrane organization process that joins two mitochondrial inner membranes to form a single membrane. [GOC:vw, PMID:17055438]"}
{"concept_id": "C3896419", "aliases": ["cardiac phospholamban complex location", "cardiac phospholamban complex", "phospholamban complex location"], "types": ["T026"], "canonical_name": "phospholamban complex", "definition": "A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels. [GOC:ame, PMID:16043693]"}
{"concept_id": "C3896420", "aliases": ["cardiac PLB complex location"], "types": ["T026"], "canonical_name": "cardiac PLB complex"}
{"concept_id": "C3896421", "aliases": ["cardiac PLN complex location"], "types": ["T026"], "canonical_name": "cardiac PLN complex"}
{"concept_id": "C3896422", "aliases": ["IRE1-RACK1-PP2A complex location"], "types": ["T026"], "canonical_name": "IRE1-RACK1-PP2A complex", "definition": "A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A. [GOC:bf, GOC:PARL, PMID:20103773]"}
{"concept_id": "C3896423", "aliases": ["IRE1alpha-RACK1-PP2A complex location"], "types": ["T026"], "canonical_name": "IRE1alpha-RACK1-PP2A complex"}
{"concept_id": "C3896424", "aliases": ["HER4 receptor binding"], "types": ["T044"], "canonical_name": "ErbB-4 class receptor binding", "definition": "Binding to the protein-tyrosine kinase receptor ErbB-4/HER4. [GOC:sl, PMID:18523588]"}
{"concept_id": "C3896425", "aliases": ["submandibular gland branching morphogenesis", "submandibular gland ductal branching"], "types": ["T040"], "canonical_name": "branching involved in submandibular gland morphogenesis", "definition": "The process in which the branching structure of the submandibular gland is generated and organized. [PMID:15063181, PMID:20890964]"}
{"concept_id": "C3896426", "aliases": [], "types": ["T026"], "canonical_name": "mutator focus", "definition": "A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules. [GOC:kmv, PMID:22713602, PMID:25635455]"}
{"concept_id": "C3896427", "aliases": ["protein phosphatase T binding"], "types": ["T044"], "canonical_name": "protein phosphatase 5 binding", "definition": "Binding to protein phosphatase 5. [PMID:8943293]"}
{"concept_id": "C3896428", "aliases": [], "types": ["T026"], "canonical_name": "proximal dendrite", "definition": "The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma). [GOC:aruk, GOC:bc, PMID:16899232]"}
{"concept_id": "C3896429", "aliases": [], "types": ["T040"], "definition": "A life cycle stage during which the reproductive capacity and fitness of an organism declines. [PMID:24914937, PMID:25523082, PMID:27353257]", "canonical_name": "reproductive senescence"}
{"concept_id": "C3896430", "aliases": [], "types": ["T043"], "canonical_name": "response to prolactin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation. [PMID:7760850]"}
{"concept_id": "C3896431", "aliases": ["response to G-CSF"], "types": ["T043"], "canonical_name": "response to granulocyte colony-stimulating factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus. [PMID:9488469]"}
{"concept_id": "C3896433", "aliases": [], "types": ["T044"], "canonical_name": "inositol-2,4,5-triphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate. [PMID:15316017]"}
{"concept_id": "C3896434", "aliases": [], "types": ["T040"], "canonical_name": "response to iron ion starvation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion. [PMID:16208485]"}
{"concept_id": "C3896436", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to granulocyte colony-stimulating factor", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus. [PMID:9488469]"}
{"concept_id": "C3896437", "aliases": [], "types": ["T044"], "canonical_name": "microtubule site clamp", "definition": "The binding activity of a molecule that attaches the spindle microtubules to the kinetochore. [PMID:20723757]"}
{"concept_id": "C3896439", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to prolactin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. [PMID:7760850]"}
{"concept_id": "C3896440", "aliases": ["C/EBP homodimer complex location", "C/EBP complex location", "C/EBP transcription factor complex location", "C/EBP transcription factor complex", "C/EBP homodimer complex"], "types": ["T026"], "canonical_name": "C/EBP complex", "definition": "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities. [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121]"}
{"concept_id": "C3896441", "aliases": ["C/EBPalpha complex location"], "types": ["T026"], "canonical_name": "C/EBPalpha complex"}
{"concept_id": "C3896442", "aliases": ["C/EBPalpha homodimer complex location"], "types": ["T026"], "canonical_name": "C/EBPalpha homodimer complex"}
{"concept_id": "C3896443", "aliases": ["C/EBPbeta complex location"], "types": ["T026"], "canonical_name": "C/EBPbeta complex"}
{"concept_id": "C3896444", "aliases": ["C/EBPbeta homodimer complex location"], "types": ["T026"], "canonical_name": "C/EBPbeta homodimer complex"}
{"concept_id": "C3896445", "aliases": [], "types": ["T044"], "canonical_name": "inositol-4,5,6-triphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate. [GOC:al, PMID:15316017]"}
{"concept_id": "C3896446", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate. [GOC:al, PMID:15316017]"}
{"concept_id": "C3896447", "aliases": [], "types": ["T044"], "canonical_name": "inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate. [GOC:al, PMID:15316017]"}
{"concept_id": "C3896448", "aliases": [], "types": ["T044"], "canonical_name": "inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate. [GOC:al, PMID:15316017]"}
{"concept_id": "C3896451", "aliases": [], "types": ["T043"], "canonical_name": "sebum secreting cell proliferation", "definition": "The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum. [GOC:hjd, PMID:16901790, PMID:18474083]"}
{"concept_id": "C3896452", "aliases": [], "types": ["T043"], "canonical_name": "sebocyte proliferation"}
{"concept_id": "C3896453", "aliases": [], "types": ["T044"], "canonical_name": "4 iron, 3 sulfur cluster binding", "definition": "Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria. [GOC:am, PMID:23267108]"}
{"concept_id": "C3896454", "aliases": [], "types": ["T044"], "canonical_name": "4Fe-3S cluster binding"}
{"concept_id": "C3896455", "aliases": [], "types": ["T043"], "canonical_name": "t-SNARE clustering", "definition": "The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies. [PMID:22528485]"}
{"concept_id": "C3896456", "aliases": ["transferase complex location, transferring nitrogenous groups", "transferase complex, transferring nitrogenous groups", "transnitrosylase complex location"], "types": ["T026"], "canonical_name": "transnitrosylase complex", "definition": "A transferase complex which is capable of transferring nitrogenous groups from one component to another. [GOC:bhm, PMID:25417112]"}
{"concept_id": "C3896457", "aliases": ["manganese ion storage", "manganese ion retention", "storage of manganese ion", "manganese ion sequestration", "sequestration of manganese ion", "manganese ion sequestering", "retention of manganese ion"], "types": ["T038"], "canonical_name": "sequestering of manganese ion", "definition": "The process of binding or confining manganese ions such that they are separated from other components of a biological system. [GOC:bhm, PMID:25417112]"}
{"concept_id": "C3896458", "aliases": ["calprotectin complex location"], "types": ["T026"], "canonical_name": "calprotectin complex", "definition": "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. [GOC:bhm, PMID:25417112]"}
{"concept_id": "C3896459", "aliases": [], "types": ["T026"], "canonical_name": "calprotectin heterodimer"}
{"concept_id": "C3896460", "aliases": ["S100A8 complex location", "S100A8 homodimer"], "types": ["T026"], "canonical_name": "S100A8 complex", "definition": "A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4). [GOC:bhm, PMID:25417112]"}
{"concept_id": "C3896461", "aliases": ["S100A9 complex location", "S100A9 homodimer"], "types": ["T026"], "canonical_name": "S100A9 complex", "definition": "A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility. [GOC:bhm, PMID:15642721]"}
{"concept_id": "C3896462", "aliases": [], "types": ["T044"], "canonical_name": "dihydroorotate dehydrogenase (fumarate) activity", "definition": "Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate. [PMID:1409592, RHEA:30059]"}
{"concept_id": "C3896463", "aliases": ["Nkx-2.5 complex location"], "types": ["T026"], "canonical_name": "Nkx-2.5 complex", "definition": "A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes. [GOC:ame, PMID:22849347]"}
{"concept_id": "C3896464", "aliases": ["Nkx-2.5 homodimer complex", "Nkx-2.5 homodimer complex location", "NKX.2-5 homodimer complex location"], "types": ["T026"], "canonical_name": "NKX.2-5 homodimer complex"}
{"concept_id": "C3896465", "aliases": ["NKX2.5 complex location"], "types": ["T026"], "canonical_name": "NKX2.5 complex"}
{"concept_id": "C3896466", "aliases": ["NKX2E homodimer complex location"], "types": ["T026"], "canonical_name": "NKX2E homodimer complex"}
{"concept_id": "C3896467", "aliases": ["(A2.p11)2 complex location", "AnxA2:S100A10 heterotetramer", "AnxA2.p11 complex", "AnxA2-p11 complex location", "Annexin A2-p11 complex", "(A2.p11)2 complex", "Annexin A2-p11 complex location", "(p11)2.(AnxA2)2 complex location", "AnxA2.p11 complex location", "(p11)2.(AnxA2)2 complex"], "types": ["T026"], "canonical_name": "AnxA2-p11 complex", "definition": "A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10). [GOC:bf, GOC:BHF, GOC:nc, PMID:18799458, PMID:23483454]"}
{"concept_id": "C3896468", "aliases": [], "types": ["T026"], "canonical_name": "Annexin A2 tetramer"}
{"concept_id": "C3896469", "aliases": ["PCSK9:low-density lipoprotein receptor complex location", "PCSK9/LDL-R complex", "PCSK9/LDL-R complex location", "PCSK9-LDLR complex location", "PCSK9:low-density lipoprotein receptor complex", "PCSK9.LDLR complex location", "PCSK9.LDLR complex"], "types": ["T026"], "canonical_name": "PCSK9-LDLR complex", "definition": "A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. [GOC:BHF, GOC:nc, PMID:18250299, PMID:24440079]"}
{"concept_id": "C3896470", "aliases": ["PCSK9:EGF-A complex location"], "types": ["T026"], "canonical_name": "PCSK9:EGF-A complex"}
{"concept_id": "C3896471", "aliases": ["PCSK9:ANXA2 complex", "PCSK9.AnxA2 complex", "PCSK9-AnxA2 complex location", "PCSK9.AnxA2 complex location", "PCSK9:ANXA2 complex location", "PCSK9-Annexin A2 complex", "PCSK9-Annexin A2 complex location"], "types": ["T026"], "canonical_name": "PCSK9-AnxA2 complex", "definition": "A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and annexin A2 (AnxA2). [GOC:BHF, GOC:nc, PMID:22848640]"}
{"concept_id": "C3896472", "aliases": ["vesicle fusion with ERGIC membrane", "vesicle fusion with ER-Golgi intermediate compartment (ERGIC) membrane", "vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment membrane", "vesicle fusion with ER-Golgi intermediate compartment membrane"], "types": ["T043"], "canonical_name": "vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane", "definition": "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896473", "aliases": ["ER-Golgi intermediate compartment derived vesicle fusion with ER membrane", "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with ER membrane"], "types": ["T043"], "canonical_name": "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane", "definition": "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896474", "aliases": [], "types": ["T043"], "canonical_name": "vesicle fusion with Golgi cis cisterna membrane", "definition": "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896475", "aliases": [], "types": ["T043"], "canonical_name": "vesicle fusion with Golgi medial cisterna membrane", "definition": "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896476", "aliases": [], "types": ["T043"], "canonical_name": "medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane", "definition": "The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896477", "aliases": ["intrinsic component of endoplasmic reticulum-Golgi intermediate compartment membrane"], "types": ["T026"], "canonical_name": "intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane", "definition": "The component of the ERGIC membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896478", "aliases": ["cis-Golgi cisterna membrane"], "types": ["T026"], "canonical_name": "Golgi cis cisterna membrane", "definition": "The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896479", "aliases": ["medial-Golgi cisterna membrane"], "types": ["T026"], "canonical_name": "Golgi medial cisterna membrane", "definition": "The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896480", "aliases": ["trans-Golgi cisterna membrane"], "types": ["T026"], "canonical_name": "Golgi trans cisterna membrane", "definition": "The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896481", "aliases": ["mitochondrion inner membrane assembly complex location", "mitochondrion inner membrane assembly complex", "INAC complex", "mitochondrial inner membrane assembly complex location", "INAC complex location"], "types": ["T026"], "canonical_name": "mitochondrial inner membrane assembly complex", "definition": "A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion. [GOC:bhm, PMID:24942160]"}
{"concept_id": "C3896482", "aliases": ["inner membrane assembly complex location"], "types": ["T026"], "canonical_name": "inner membrane assembly complex"}
{"concept_id": "C3896483", "aliases": [], "types": ["T044"], "canonical_name": "histone H4-K16 deacetylation", "definition": "The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone. [PMID:17446861]"}
{"concept_id": "C3896484", "aliases": [], "types": ["T044"], "canonical_name": "histone H4-K12 deacetylation", "definition": "The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone. [PMID:17446861]"}
{"concept_id": "C3896485", "aliases": ["response to MSH"], "types": ["T043"], "canonical_name": "response to melanocyte-stimulating hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates. [PMID:17036007]"}
{"concept_id": "C3896486", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 2A inhibitor activity"}
{"concept_id": "C3896487", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 2 inhibitor activity"}
{"concept_id": "C3896488", "aliases": ["CSF1:C-FMS complex location", "macrophage colony-stimulating factor:receptor complex location", "macrophage colony-stimulating factor:receptor complex", "M-CSF:FMS complex location", "CSF1:C-FMS complex", "M-CSF:FMS complex", "CSF1-CSF1R complex location"], "types": ["T026"], "canonical_name": "CSF1-CSF1R complex", "definition": "A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand. [GOC:bf, GOC:BHF, GOC:nc, PMID:19017797]"}
{"concept_id": "C3896489", "aliases": ["M-CSF:C-FMS complex location"], "types": ["T026"], "canonical_name": "M-CSF:C-FMS complex"}
{"concept_id": "C3896490", "aliases": ["M-CSF:CSF1R complex location"], "types": ["T026"], "canonical_name": "M-CSF:CSF1R complex"}
{"concept_id": "C3896491", "aliases": [], "types": ["T043"], "canonical_name": "DNA double-strand break attachment to nuclear envelope", "definition": "A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs. [PMID:24943839]"}
{"concept_id": "C3896492", "aliases": ["protein-lipid-RNA complex location"], "types": ["T026"], "canonical_name": "protein-lipid-RNA complex", "definition": "A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other. [GOC:vesicles, PMID:21423178, PMID:22028337, PMID:23559634]"}
{"concept_id": "C3896493", "aliases": ["miRNA-lipoprotein complex location"], "types": ["T026"], "canonical_name": "miRNA-lipoprotein complex"}
{"concept_id": "C3896494", "aliases": ["HDL-containing protein-lipid-RNA complex location"], "types": ["T026"], "canonical_name": "HDL-containing protein-lipid-RNA complex", "definition": "A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other. [GOC:vesicles, PMID:21423178, PMID:23559634]"}
{"concept_id": "C3896495", "aliases": ["LDL-containing protein-lipid-RNA complex location"], "types": ["T026"], "canonical_name": "LDL-containing protein-lipid-RNA complex", "definition": "A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other. [GOC:vesicles, PMID:23559634]"}
{"concept_id": "C3896496", "aliases": ["ER-derived vesicle fusion with ERGIC membrane", "ER-derived vesicle fusion with ER-Golgi intermediate compartment membrane"], "types": ["T043"], "canonical_name": "endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane", "definition": "The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896497", "aliases": ["Golgi vesicle fusion with ERGIC membrane", "Golgi vesicle fusion with ER-Golgi intermediate compartment membrane"], "types": ["T043"], "canonical_name": "Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane", "definition": "The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896498", "aliases": ["ERGIC-derived vesicle fusion with cis-Golgi cisterna membrane", "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with cis-Golgi cisterna membrane", "ER-Golgi intermediate compartment derived vesicle fusion with cis-Golgi cisterna membrane", "ERGIC-derived vesicle fusion with Golgi cis cisterna membrane", "ER-Golgi intermediate compartment derived vesicle fusion with Golgi cis cisterna membrane"], "types": ["T043"], "canonical_name": "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane", "definition": "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896499", "aliases": ["medial-Golgi cisterna-derived vesicle fusion with cis-Golgi cisterna membrane"], "types": ["T043"], "canonical_name": "Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane", "definition": "The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896500", "aliases": ["cis-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane"], "types": ["T043"], "canonical_name": "cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane", "definition": "The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896501", "aliases": ["trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane"], "types": ["T043"], "canonical_name": "trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane", "definition": "The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896502", "aliases": ["intrinsic component of cis-Golgi cisterna membrane"], "types": ["T026"], "canonical_name": "intrinsic component of Golgi cis cisterna membrane", "definition": "The component of the Golgi cis cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896503", "aliases": ["intrinsic component of medial-Golgi cisterna membrane"], "types": ["T026"], "canonical_name": "intrinsic component of Golgi medial cisterna membrane", "definition": "The component of the Golgi medial cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896504", "aliases": ["intrinsic component of trans-Golgi cisterna membrane"], "types": ["T026"], "canonical_name": "intrinsic component of Golgi trans cisterna membrane", "definition": "The component of the Golgi trans cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896505", "aliases": ["USH2 quaternary protein complex", "USH2 complex location", "USH2 quaternary protein complex location"], "types": ["T026"], "canonical_name": "USH2 complex", "definition": "A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7. [GOC:krc, PMID:25406310]"}
{"concept_id": "C3896506", "aliases": [], "types": ["T044"], "canonical_name": "protein depalmitoleylation", "definition": "The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein. [PMID:25731175]"}
{"concept_id": "C3896507", "aliases": [], "types": ["T044"], "canonical_name": "palmitoleoyltransferase activity", "definition": "Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule. [PMID:17141155, PMID:25731175]"}
{"concept_id": "C3896508", "aliases": [], "types": ["T044"], "canonical_name": "palmitoleyl hydrolase activity", "definition": "Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate. [PMID:25731175]"}
{"concept_id": "C3896509", "aliases": ["establishment or maintenance of nucleolar chromatin architecture", "nucleolar chromatin organisation"], "types": ["T043"], "canonical_name": "nucleolar chromatin organization", "definition": "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin. [PMID:18362178]"}
{"concept_id": "C3896510", "aliases": ["integral component of ER-Golgi intermediate compartment membrane", "integral component of ERGIC membrane", "integral component of endoplasmic reticulum-Golgi intermediate compartment membrane"], "types": ["T026"], "canonical_name": "integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane", "definition": "The component of the ERGIC membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896511", "aliases": ["integral component of cis-Golgi cisterna membrane"], "types": ["T026"], "canonical_name": "integral component of Golgi cis cisterna membrane", "definition": "The component of the Golgi cis membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896512", "aliases": ["integral component of medial-Golgi cisterna membrane"], "types": ["T026"], "canonical_name": "integral component of Golgi medial cisterna membrane", "definition": "The component of the Golgi medial membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896513", "aliases": ["integral component of trans-Golgi cisterna membrane"], "types": ["T026"], "canonical_name": "integral component of Golgi trans cisterna membrane", "definition": "The component of the Golgi trans membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:bhm, PMID:16038056, PMID:24119662]"}
{"concept_id": "C3896514", "aliases": ["hepatoblast proliferation"], "types": ["T043"], "canonical_name": "cholangiocyte proliferation", "definition": "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. [PMID:24434010]"}
{"concept_id": "C3896515", "aliases": ["MAD1 complex location", "MAD1 homodimer"], "types": ["T026"], "canonical_name": "MAD1 complex", "definition": "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). [GOC:bhm, intAct:EBI-10691224, PMID:22493223, PMID:22898774]"}
{"concept_id": "C3896517", "aliases": ["presynaptic active zone organisation"], "types": ["T043"], "canonical_name": "presynaptic active zone organization", "definition": "A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone. [GOC:pr, PMID:16865347, PMID:17068967]"}
{"concept_id": "C3896518", "aliases": ["MutS mismatch repair complex location", "MutS mismatch repair complex", "MutS complex location"], "types": ["T026"], "canonical_name": "MutS complex", "definition": "A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations. [GOC:bhm, PMID:21666597]"}
{"concept_id": "C3896519", "aliases": ["beta-catenin-ICAT complex location", "CTNNB1-CTNNBIP1 complex", "CTNNB1-CTNNBIP1 complex location"], "types": ["T026"], "canonical_name": "beta-catenin-ICAT complex", "definition": "Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex. [GOC:bhm, PMID:12408824]"}
{"concept_id": "C3896520", "aliases": ["HFE-transferrin receptor complex location"], "types": ["T026"], "canonical_name": "HFE-transferrin receptor complex", "definition": "A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription. [GOC:BHF, GOC:kom, PMID:25147378]"}
{"concept_id": "C3896521", "aliases": ["Baculoviral IAP repeat-containing protein 5 complex", "survivin complex location", "Baculoviral IAP repeat-containing protein 5 complex location"], "types": ["T026"], "canonical_name": "survivin complex", "definition": "A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC). [GOC:bhm, PMID:10949038]"}
{"concept_id": "C3896522", "aliases": ["survivin homodimer complex location"], "types": ["T026"], "canonical_name": "survivin homodimer complex"}
{"concept_id": "C3896523", "aliases": ["HPGT"], "types": ["T044"], "canonical_name": "hydroxyproline O-galactosyltransferase activity", "definition": "Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone. [PMID:25600942]"}
{"concept_id": "C3896524", "aliases": ["mRNA coding region binding", "mRNA coding sequence binding"], "types": ["T045"], "canonical_name": "mRNA CDS binding", "definition": "Binding to an mRNA molecule coding sequence (CDS). [GOC:kmv, PMID:25805859, SO:0000316]"}
{"concept_id": "C3896525", "aliases": [], "types": ["T026"], "canonical_name": "axonemal central apparatus", "definition": "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules. [GOC:cilia, PMID:21586547, PMID:9295136]"}
{"concept_id": "C3896526", "aliases": [], "types": ["T026"], "canonical_name": "axonemal central bridge", "definition": "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules. [GOC:cilia, PMID:21586547, PMID:9295136]"}
{"concept_id": "C3896527", "aliases": [], "types": ["T026"], "canonical_name": "axonemal central pair projection", "definition": "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules. [GOC:cilia, PMID:21586547, PMID:9295136]"}
{"concept_id": "C3896528", "aliases": [], "types": ["T026"], "canonical_name": "C1 axonemal microtubule", "definition": "One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections. [GOC:cilia, PMID:21586547, PMID:9295136]"}
{"concept_id": "C3896529", "aliases": [], "types": ["T026"], "canonical_name": "C1 tubule"}
{"concept_id": "C3896530", "aliases": [], "types": ["T026"], "canonical_name": "C2 axonemal microtubule", "definition": "One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections. [GOC:cilia, PMID:21586547, PMID:9295136]"}
{"concept_id": "C3896531", "aliases": [], "types": ["T026"], "canonical_name": "C2 tubule"}
{"concept_id": "C3896532", "aliases": [], "types": ["T043"], "canonical_name": "regulation of FtsZ-dependent cytokinesis", "definition": "Any process that modulates the frequency, rate or extent of FtsZ-dependent cytokinesis. [GOC:mah]"}
{"concept_id": "C3896533", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of FtsZ-dependent cytokinesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of Ftsz-dependent cytokinesis. [GOC:mah]"}
{"concept_id": "C3896534", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of FtsZ-dependent cytokinesis", "definition": "Any process that activates or increases the frequency, rate or extent of Ftsz-dependent cytokinesis. [GOC:mah]"}
{"concept_id": "C3896535", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell separation after cytokinesis"}
{"concept_id": "C3896536", "aliases": [], "types": ["T043"], "canonical_name": "regulation of meiotic nuclear division", "definition": "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. [GOC:ems, GOC:ma]"}
{"concept_id": "C3896537", "aliases": [], "types": ["T043"], "canonical_name": "inhibition by virus of host cell division"}
{"concept_id": "C3896538", "aliases": [], "types": ["T044"], "canonical_name": "ATF6-beta UPR branch"}
{"concept_id": "C3896540", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase"}
{"concept_id": "C3896541", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of SUMO ligase activity"}
{"concept_id": "C3896542", "aliases": [], "types": ["T044"], "canonical_name": "activation of mucopeptide N-acetylmuramoylhydrolase activity"}
{"concept_id": "C3896543", "aliases": [], "types": ["T043"], "canonical_name": "multi-ciliated epithelial cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. [GO_REF:0000086, GOC:sp, GOC:TermGenie, PMID:22231168, PMID:24934224]"}
{"concept_id": "C3896544", "aliases": [], "types": ["T039"], "canonical_name": "activation of asexual reproduction"}
{"concept_id": "C3896545", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of inward rectifier potassium channel activity"}
{"concept_id": "C4042777", "aliases": [], "types": ["T043"], "definition": "The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches. [GOC:aruk, GOC:bc, PMID:23270857]", "canonical_name": "dendrite arborization"}
{"concept_id": "C4042929", "aliases": [], "types": ["T026"], "definition": "The very long and thin extensions of telocytes' cell surface, that have alternating thick and thin sections called podoms and podomers.", "canonical_name": "telopode"}
{"concept_id": "C4048301", "aliases": [], "types": ["T026"], "definition": "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell. [GOC:ns]", "canonical_name": "micronucleus"}
{"concept_id": "C4048619", "aliases": ["post-translational amino acid modification"], "types": ["T044"], "canonical_name": "posttranslational amino acid modification"}
{"concept_id": "C4048749", "aliases": ["co-translational amino acid modification"], "types": ["T044"], "canonical_name": "cotranslational amino acid modification"}
{"concept_id": "C4082184", "aliases": ["peristromal region viral factory"], "types": ["T026"], "definition": "A nuclear viral factory formed at the periphery of the host cell nucleus by Baculoviruses. [PMID:18434402, VZ:1951]", "canonical_name": "PR"}
{"concept_id": "C4082187", "aliases": ["metachromatic granule", "volutin granule"], "types": ["T026"], "canonical_name": "acidocalcisome", "definition": "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations. [GOC:mb]"}
{"concept_id": "C4083021", "aliases": ["VS"], "types": ["T026"], "definition": "A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled. [PMID:13358757, PMID:1433508, VZ:1951]", "canonical_name": "virogenic stroma"}
{"concept_id": "C4083034", "aliases": ["up-regulation of ubiquitin protein ligase activity", "up regulation of ubiquitin ligase activity", "upregulation of ubiquitin protein ligase activity", "up-regulation of protein ubiquitination activity", "positive regulation of protein ubiquitination activity", "up regulation of ubiquitin protein ligase activity", "up-regulation of ubiquitin ligase activity", "up regulation of protein ubiquitination activity", "upregulation of ubiquitin ligase activity", "upregulation of protein ubiquitination activity", "positive regulation of ubiquitin ligase activity"], "types": ["T044"], "canonical_name": "positive regulation of ubiquitin protein ligase activity", "definition": "Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity. [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882]"}
{"concept_id": "C4083278", "aliases": ["down-regulation of serine-type peptidase activity", "downregulation of serine-type peptidase activity"], "types": ["T044"], "canonical_name": "down regulation of serine-type peptidase activity"}
{"concept_id": "C4083279", "aliases": ["upregulation of serine-type peptidase activity", "up-regulation of serine-type peptidase activity"], "types": ["T044"], "canonical_name": "up regulation of serine-type peptidase activity"}
{"concept_id": "C4083287", "aliases": [], "types": ["T043"], "canonical_name": "down-regulation of mitophagy"}
{"concept_id": "C4084932", "aliases": [], "types": ["T026"], "canonical_name": "adhesion plaque"}
{"concept_id": "C4084933", "aliases": ["anterograde axon cargo transport"], "types": ["T043"], "definition": "The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons. [GOC:dos]", "canonical_name": "anterograde axonal protein transport"}
{"concept_id": "C4084934", "aliases": ["ARR"], "types": ["T038"], "definition": "An innate immune response that is positively correlated with host plant development. As a plant develops, its innate resistance to pathogenic infections increases. The mechanisms involved in age-related resistance differ in nature or in aspects of regulation from the hypersensitive response (HR), systemic acquired resistance (SAR), or induced systemic resistance (ISR). [PMID:17635216, PMID:19694953]", "canonical_name": "age-related resistance"}
{"concept_id": "C4084936", "aliases": ["GPIb-IX-V complex", "GPIb-V-IX complex", "CD42", "glycoprotein Ib-IX-V complex location", "GPIb-IX-V complex location", "GPIb-V-IX complex location"], "types": ["T026"], "definition": "A transmembrane signalling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation. [GOC:bhm, PMID:1730602, PMID:23336709, PMID:25297919]", "canonical_name": "glycoprotein Ib-IX-V complex"}
{"concept_id": "C4084938", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+. [GOC:pz]", "canonical_name": "dTDP-L-rhamnose synthetase activity"}
{"concept_id": "C4084940", "aliases": [], "types": ["T044"], "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:ai]", "canonical_name": "purine/pyrimidine nucleoside diphosphate reduction"}
{"concept_id": "C4084941", "aliases": ["cellular response to PAF", "cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine"], "types": ["T043"], "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:9321918]", "canonical_name": "cellular response to platelet-activating factor"}
{"concept_id": "C4084942", "aliases": ["response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine", "response to platelet-activating factor"], "types": ["T039"], "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:9321918]", "canonical_name": "response to PAF"}
{"concept_id": "C4084943", "aliases": ["retrograde axonal protein transport"], "types": ["T043"], "definition": "The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons. [ISBN:0815316194]", "canonical_name": "retrograde axon cargo transport"}
{"concept_id": "C4084945", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: D-glycerate + NAD <=> H+ + 2-hydroxy-3-oxopropanoate + NADH. [EC:1.1.1.-, GOC:pz]", "canonical_name": "tartronate semialdehyde reductase activity"}
{"concept_id": "C4085353", "aliases": ["FPC", "flagellar pocket collar"], "types": ["T026"], "canonical_name": "flagellum pocket collar"}
{"concept_id": "C4085668", "aliases": [], "types": ["T040"], "definition": "The specific neuromuscular movement of a single organism in response to external or internal stimuli. [GOC:bf, GOC:PARL, PMID:25318560]", "canonical_name": "motor behavior"}
{"concept_id": "C4085686", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate. [PMID:6292732]", "canonical_name": "[isocitrate dehydrogenase (NADP+)] phosphatase activity"}
{"concept_id": "C4085687", "aliases": [], "types": ["T044"], "canonical_name": "Man9-mannosidase activity"}
{"concept_id": "C4085688", "aliases": [], "types": ["T026"], "canonical_name": "microparticle"}
{"concept_id": "C4085689", "aliases": ["neutral sphingomyelinase", "neutral sphingomyelin phosphodiesterase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in a neutral environment. [GOC:dph, PMID:26493087]", "canonical_name": "neutral SMase"}
{"concept_id": "C4085690", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor. [GOC:dos, GOC:jh]", "canonical_name": "nitrite reductase activity"}
{"concept_id": "C4085691", "aliases": ["prostatic acid phosphatase complex"], "types": ["T026"], "definition": "OBSOLETE. A protein complex that is capable of dephosphorylation of alky, aryl and acyl orthophosphate monoesters and phosphorylated proteins. Optimal activity in acidic environment (pH 4-6). In mammals it consists of a homodimer of ACPP. [GOC:bhm, PMID:12525165]", "canonical_name": "prostatic acid phosphatase complex location"}
{"concept_id": "C4085692", "aliases": ["pedicel", "podocyte foot"], "types": ["T026"], "definition": "A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms. [PMID:25324828]", "canonical_name": "podocyte foot process"}
{"concept_id": "C4085693", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal <=> L-proline + a standard alpha amino acid. [EC:3.4.13.9]", "canonical_name": "proline dipeptidase activity"}
{"concept_id": "C4231691", "aliases": [], "types": ["T044"], "canonical_name": "activation of Ras GTPase binding"}
{"concept_id": "C4231692", "aliases": [], "types": ["T043"], "canonical_name": "activation of endothelin-2 secretion"}
{"concept_id": "C4231693", "aliases": ["chemorepulsion of DA axon", "chemorepulsion of dopaminergic axon"], "types": ["T043"], "canonical_name": "chemorepulsion of dopaminergic neuron axon", "definition": "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308]"}
{"concept_id": "C4231694", "aliases": [], "types": ["T043"], "canonical_name": "activation of xenophagy"}
{"concept_id": "C4231695", "aliases": [], "types": ["T040"], "canonical_name": "activation of mature seedling resistance"}
{"concept_id": "C4231696", "aliases": ["downregulation of mutagenic postreplication DNA repair", "down-regulation of mutagenic postreplication DNA repair"], "types": ["T045"], "canonical_name": "down regulation of mutagenic postreplication DNA repair"}
{"concept_id": "C4231697", "aliases": ["AIP1-ERN1 complex location"], "types": ["T026"], "canonical_name": "AIP1-ERN1 complex"}
{"concept_id": "C4231698", "aliases": ["activation of endosome organization"], "types": ["T043"], "canonical_name": "activation of endosome organisation"}
{"concept_id": "C4231699", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glomerular podocyte apoptosis"}
{"concept_id": "C4231700", "aliases": [], "types": ["T043"], "canonical_name": "second meiotic metaphase/anaphase transition"}
{"concept_id": "C4231701", "aliases": [], "types": ["T043"], "canonical_name": "first meiotic metaphase/anaphase transition"}
{"concept_id": "C4231702", "aliases": [], "types": ["T044"], "canonical_name": "tethering factor for nuclear proteasome"}
{"concept_id": "C4231703", "aliases": [], "types": ["T044"], "canonical_name": "nuclear membrane proteasome adaptor"}
{"concept_id": "C4231704", "aliases": [], "types": ["T026"], "canonical_name": "LRP6 signalosome"}
{"concept_id": "C4231705", "aliases": ["beta-catenin/T-cell factor complex location"], "types": ["T026"], "canonical_name": "beta-catenin/T-cell factor complex"}
{"concept_id": "C4231706", "aliases": ["beta-catenin/lymphoid enhancer binding factor complex location"], "types": ["T026"], "canonical_name": "beta-catenin/lymphoid enhancer binding factor complex"}
{"concept_id": "C4231707", "aliases": ["beta-catenin/LEF complex location"], "types": ["T026"], "canonical_name": "beta-catenin/LEF complex"}
{"concept_id": "C4231708", "aliases": [], "types": ["T026"], "canonical_name": "flagellar pore"}
{"concept_id": "C4231709", "aliases": [], "types": ["T026"], "canonical_name": "flagellar collar"}
{"concept_id": "C4231710", "aliases": ["CTC1-OBFC1-TEN1 complex location"], "types": ["T026"], "canonical_name": "CTC1-OBFC1-TEN1 complex"}
{"concept_id": "C4231711", "aliases": ["Cdc13-Stn1-Ten1 complex location"], "types": ["T026"], "canonical_name": "Cdc13-Stn1-Ten1 complex"}
{"concept_id": "C4231715", "aliases": [], "types": ["T043"], "canonical_name": "response to sermorelin"}
{"concept_id": "C4231716", "aliases": ["Wnt-induced Frizzled-LRP5/6 complex location"], "types": ["T026"], "canonical_name": "Wnt-induced Frizzled-LRP5/6 complex"}
{"concept_id": "C4231717", "aliases": ["WNT-FZD-LRP6 complex location"], "types": ["T026"], "canonical_name": "WNT-FZD-LRP6 complex"}
{"concept_id": "C4231718", "aliases": ["WNT-FZD-LRP5 complex location"], "types": ["T026"], "canonical_name": "WNT-FZD-LRP5 complex"}
{"concept_id": "C4231719", "aliases": ["Wnt receptor complex location"], "types": ["T026"], "canonical_name": "Wnt receptor complex"}
{"concept_id": "C4231720", "aliases": ["Fz/Wnt/LRP6 complex location"], "types": ["T026"], "canonical_name": "Fz/Wnt/LRP6 complex"}
{"concept_id": "C4231721", "aliases": ["Frizzled-LRP5/6 complex location"], "types": ["T026"], "canonical_name": "Frizzled-LRP5/6 complex"}
{"concept_id": "C4231722", "aliases": ["galactose-containing glycoprotein complex location"], "types": ["T026"], "canonical_name": "galactose-containing glycoprotein complex"}
{"concept_id": "C4231723", "aliases": [], "types": ["T043"], "canonical_name": "thyroid follicular cell proliferation"}
{"concept_id": "C4231724", "aliases": [], "types": ["T043"], "canonical_name": "Hurthle cell proliferation"}
{"concept_id": "C4231727", "aliases": [], "types": ["T043"], "canonical_name": "endothelin-1 secretion"}
{"concept_id": "C4231731", "aliases": [], "types": ["T043"], "canonical_name": "matrix metalloproteinase secretion"}
{"concept_id": "C4231733", "aliases": [], "types": ["T026"], "canonical_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer"}
{"concept_id": "C4231734", "aliases": [], "types": ["T026"], "canonical_name": "shedding vesicle"}
{"concept_id": "C4231735", "aliases": ["Titin-Tcap complex location"], "types": ["T026"], "canonical_name": "Titin-Tcap complex"}
{"concept_id": "C4231736", "aliases": ["DNA incision involved in alternative excision repair", "alternative excision repair, DNA incision"], "types": ["T045"], "canonical_name": "DNA incision involved in AER"}
{"concept_id": "C4231737", "aliases": ["galectin-2 complex location"], "types": ["T026"], "canonical_name": "galectin-2 complex"}
{"concept_id": "C4231738", "aliases": ["galectin-1 complex location"], "types": ["T026"], "canonical_name": "galectin-1 complex"}
{"concept_id": "C4231739", "aliases": ["ERN1-RACK1-PP2A complex location"], "types": ["T026"], "canonical_name": "ERN1-RACK1-PP2A complex"}
{"concept_id": "C4231740", "aliases": ["ERN1-TRAF2-ASK1 complex location"], "types": ["T026"], "canonical_name": "ERN1-TRAF2-ASK1 complex"}
{"concept_id": "C4231742", "aliases": ["ERN1 complex location"], "types": ["T026"], "canonical_name": "ERN1 complex"}
{"concept_id": "C4231743", "aliases": [], "types": ["T043"], "canonical_name": "activation of Rhp51-dependent recombinational repair"}
{"concept_id": "C4231744", "aliases": [], "types": ["T043"], "canonical_name": "activation of Rad51-dependent recombinational repair"}
{"concept_id": "C4231745", "aliases": [], "types": ["T043"], "canonical_name": "activation of HRR"}
{"concept_id": "C4231746", "aliases": [], "types": ["T045"], "canonical_name": "activation of homology-directed repair"}
{"concept_id": "C4231747", "aliases": [], "types": ["T045"], "canonical_name": "activation of homologous recombinational repair"}
{"concept_id": "C4231748", "aliases": [], "types": ["T043"], "canonical_name": "activation of HDR"}
{"concept_id": "C4231749", "aliases": [], "types": ["T043"], "canonical_name": "activation of double-strand break repair via homologous recombination"}
{"concept_id": "C4231750", "aliases": ["upregulation of proteolysis within lysosome", "up-regulation of proteolysis within lysosome"], "types": ["T044"], "canonical_name": "up regulation of proteolysis within lysosome"}
{"concept_id": "C4231751", "aliases": ["up-regulation of lysosomal proteolysis", "upregulation of lysosomal proteolysis"], "types": ["T043"], "canonical_name": "up regulation of lysosomal proteolysis"}
{"concept_id": "C4231752", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of proteolysis within lysosome"}
{"concept_id": "C4231753", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of lysosomal proteolysis"}
{"concept_id": "C4231754", "aliases": [], "types": ["T044"], "canonical_name": "activation of proteolysis within lysosome"}
{"concept_id": "C4231755", "aliases": [], "types": ["T044"], "canonical_name": "activation of lysosomal proteolysis"}
{"concept_id": "C4231756", "aliases": [], "types": ["T044"], "canonical_name": "activation of lysosomal protein degradation"}
{"concept_id": "C4231757", "aliases": [], "types": ["T044"], "canonical_name": "activation of lysosomal protein catabolism"}
{"concept_id": "C4231758", "aliases": [], "types": ["T043"], "canonical_name": "activation of lysosomal protein catabolic process"}
{"concept_id": "C4231759", "aliases": [], "types": ["T044"], "canonical_name": "activation of cellular protein degradation in lysosome"}
{"concept_id": "C4231760", "aliases": [], "types": ["T044"], "canonical_name": "activation of cellular protein catabolism in lysosome"}
{"concept_id": "C4231761", "aliases": [], "types": ["T044"], "canonical_name": "activation of cellular protein catabolic process in lysosome"}
{"concept_id": "C4231762", "aliases": [], "types": ["T044"], "canonical_name": "activation of cellular protein breakdown in lysosome"}
{"concept_id": "C4231763", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of proteolysis within lysosome"}
{"concept_id": "C4231764", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lysosomal proteolysis"}
{"concept_id": "C4231765", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of proteolysis within lysosome"}
{"concept_id": "C4231766", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysosomal proteolysis"}
{"concept_id": "C4231767", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysosomal protein degradation"}
{"concept_id": "C4231768", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysosomal protein catabolism"}
{"concept_id": "C4231769", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of lysosomal protein catabolic process"}
{"concept_id": "C4231770", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cellular protein degradation in lysosome"}
{"concept_id": "C4231771", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cellular protein catabolism in lysosome"}
{"concept_id": "C4231772", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cellular protein catabolic process in lysosome"}
{"concept_id": "C4231773", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cellular protein breakdown in lysosome"}
{"concept_id": "C4231774", "aliases": ["downregulation of proteolysis within lysosome", "down-regulation of proteolysis within lysosome"], "types": ["T044"], "canonical_name": "down regulation of proteolysis within lysosome"}
{"concept_id": "C4231775", "aliases": ["down-regulation of lysosomal proteolysis", "downregulation of lysosomal proteolysis"], "types": ["T044"], "canonical_name": "down regulation of lysosomal proteolysis"}
{"concept_id": "C4231776", "aliases": [], "types": ["T044"], "canonical_name": "regulation of proteolysis within lysosome"}
{"concept_id": "C4231777", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lysosomal proteolysis"}
{"concept_id": "C4231778", "aliases": [], "types": ["T043"], "canonical_name": "activation of phagosome maturation"}
{"concept_id": "C4231779", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of phagosome maturation"}
{"concept_id": "C4231780", "aliases": [], "types": ["T039"], "canonical_name": "activation of photosynthesis"}
{"concept_id": "C4231781", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of photosynthesis"}
{"concept_id": "C4231782", "aliases": [], "types": ["T043"], "canonical_name": "activation of membrane invagination"}
{"concept_id": "C4231783", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane invagination"}
{"concept_id": "C4231784", "aliases": [], "types": ["T044"], "canonical_name": "activation of voltage-sensitive sodium channel"}
{"concept_id": "C4231785", "aliases": [], "types": ["T043"], "canonical_name": "activation of voltage-gated sodium ion channel activity"}
{"concept_id": "C4231786", "aliases": ["activation of voltage-gated sodium channel activity"], "types": ["T043"], "canonical_name": "activation of voltage gated sodium channel activity"}
{"concept_id": "C4231787", "aliases": [], "types": ["T043"], "canonical_name": "activation of voltage-dependent sodium channel activity"}
{"concept_id": "C4231788", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of voltage-sensitive sodium channel"}
{"concept_id": "C4231789", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of voltage-gated sodium ion channel activity"}
{"concept_id": "C4231790", "aliases": ["inhibition of voltage-gated sodium channel activity"], "types": ["T043"], "canonical_name": "inhibition of voltage gated sodium channel activity"}
{"concept_id": "C4231791", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of voltage-dependent sodium channel activity"}
{"concept_id": "C4231792", "aliases": [], "types": ["T039"], "canonical_name": "activation of smooth muscle hypertrophy"}
{"concept_id": "C4231793", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of smooth muscle hypertrophy"}
{"concept_id": "C4231794", "aliases": [], "types": ["T043"], "canonical_name": "proteolysis within lysosome"}
{"concept_id": "C4231795", "aliases": [], "types": ["T043"], "canonical_name": "lysosomal proteolysis"}
{"concept_id": "C4231796", "aliases": ["upregulation of crista ectodermalis apicalis formation", "up-regulation of crista ectodermalis apicalis formation"], "types": ["T042"], "canonical_name": "up regulation of crista ectodermalis apicalis formation"}
{"concept_id": "C4231797", "aliases": ["upregulation of AER formation", "up-regulation of AER formation"], "types": ["T043"], "canonical_name": "up regulation of AER formation"}
{"concept_id": "C4231798", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of crista ectodermalis apicalis formation"}
{"concept_id": "C4231799", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of AER formation"}
{"concept_id": "C4231800", "aliases": ["upregulation of apical epidermal ridge formation", "up regulation of apical epidermal ridge formation", "upregulation of apical ectodermal ridge formation", "up-regulation of apical ectodermal ridge formation", "up-regulation of apical epidermal ridge formation", "activation of AER formation", "up regulation of apical ectodermal ridge formation", "positive regulation of apical epidermal ridge formation"], "types": ["T042"], "canonical_name": "positive regulation of apical ectodermal ridge formation", "definition": "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. [GO_REF:0000058, GOC:TermGenie, PMID:18359901]"}
{"concept_id": "C4231801", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of crista ectodermalis apicalis formation"}
{"concept_id": "C4231802", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of AER formation"}
{"concept_id": "C4231803", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of crista ectodermalis apicalis formation"}
{"concept_id": "C4231804", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of apical epidermal ridge formation"}
{"concept_id": "C4231805", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of apical ectodermal ridge formation"}
{"concept_id": "C4231806", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of AER formation"}
{"concept_id": "C4231807", "aliases": ["down-regulation of crista ectodermalis apicalis formation", "downregulation of crista ectodermalis apicalis formation"], "types": ["T039"], "canonical_name": "down regulation of crista ectodermalis apicalis formation"}
{"concept_id": "C4231808", "aliases": ["downregulation of AER formation", "down-regulation of AER formation"], "types": ["T042"], "canonical_name": "down regulation of AER formation"}
{"concept_id": "C4231809", "aliases": [], "types": ["T043"], "canonical_name": "regulation of crista ectodermalis apicalis formation"}
{"concept_id": "C4231810", "aliases": ["regulation of apical epidermal ridge formation", "regulation of AER formation"], "types": ["T042"], "canonical_name": "regulation of apical ectodermal ridge formation", "definition": "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. [GO_REF:0000058, GOC:TermGenie, PMID:18359901]"}
{"concept_id": "C4231811", "aliases": [], "types": ["T042"], "canonical_name": "crista ectodermalis apicalis formation"}
{"concept_id": "C4231812", "aliases": [], "types": ["T042"], "canonical_name": "AER formation"}
{"concept_id": "C4231813", "aliases": [], "types": ["T043"], "canonical_name": "activation of viral DNA genome packaging via site-specific sequence recognition"}
{"concept_id": "C4231814", "aliases": [], "types": ["T043"], "canonical_name": "activation of meiotic chromosome separation"}
{"concept_id": "C4231815", "aliases": [], "types": ["T043"], "canonical_name": "activation of meiotic chromosome resolution"}
{"concept_id": "C4231816", "aliases": [], "types": ["T043"], "canonical_name": "activation of chromosome separation during meiosis"}
{"concept_id": "C4231817", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of meiotic chromosome separation"}
{"concept_id": "C4231818", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of meiotic chromosome resolution"}
{"concept_id": "C4231819", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chromosome separation during meiosis"}
{"concept_id": "C4231820", "aliases": ["upregulation of axonal protein transport", "up-regulation of axonal protein transport"], "types": ["T043"], "canonical_name": "up regulation of axonal protein transport"}
{"concept_id": "C4231821", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of axonal protein transport"}
{"concept_id": "C4231822", "aliases": [], "types": ["T043"], "canonical_name": "activation of axonal protein transport"}
{"concept_id": "C4231823", "aliases": [], "types": ["T043"], "canonical_name": "activation of axo-dendritic protein transport"}
{"concept_id": "C4231824", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of axonal protein transport"}
{"concept_id": "C4231825", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axonal protein transport"}
{"concept_id": "C4231826", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axo-dendritic protein transport"}
{"concept_id": "C4231827", "aliases": ["down-regulation of axonal protein transport", "downregulation of axonal protein transport"], "types": ["T043"], "canonical_name": "down regulation of axonal protein transport"}
{"concept_id": "C4231828", "aliases": [], "types": ["T043"], "canonical_name": "regulation of axonal protein transport"}
{"concept_id": "C4231829", "aliases": [], "types": ["T044"], "canonical_name": "activation of psychosine hydrolase activity"}
{"concept_id": "C4231830", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucosylsphingosine beta-glucosidase activity"}
{"concept_id": "C4231831", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucosylsphingosine beta-D-glucosidase activity"}
{"concept_id": "C4231832", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucosylcerebrosidase activity"}
{"concept_id": "C4231833", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucosylceramidase activity"}
{"concept_id": "C4231834", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucosphingosine glucosylhydrolase activity"}
{"concept_id": "C4231835", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucocerebrosidase activity"}
{"concept_id": "C4231836", "aliases": [], "types": ["T044"], "canonical_name": "activation of GlcCer-beta-glucosidase activity"}
{"concept_id": "C4231837", "aliases": [], "types": ["T044"], "canonical_name": "activation of D-glucosyl-N-acylsphingosine glucohydrolase activity"}
{"concept_id": "C4231838", "aliases": [], "types": ["T044"], "canonical_name": "activation of ceramide glucosidase activity"}
{"concept_id": "C4231839", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-glucosylceramidase activity"}
{"concept_id": "C4231840", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-glucocerebrosidase activity"}
{"concept_id": "C4231841", "aliases": [], "types": ["T044"], "canonical_name": "activation of beta-D-glucocerebrosidase activity"}
{"concept_id": "C4231842", "aliases": [], "types": ["T044"], "canonical_name": "activation of acid beta-glucosidase activity"}
{"concept_id": "C4231843", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of psychosine hydrolase activity"}
{"concept_id": "C4231844", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucosylsphingosine beta-glucosidase activity"}
{"concept_id": "C4231845", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucosylsphingosine beta-D-glucosidase activity"}
{"concept_id": "C4231846", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucosylcerebrosidase activity"}
{"concept_id": "C4231847", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucosylceramidase activity"}
{"concept_id": "C4231848", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucosphingosine glucosylhydrolase activity"}
{"concept_id": "C4231849", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucocerebrosidase activity"}
{"concept_id": "C4231850", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of GlcCer-beta-glucosidase activity"}
{"concept_id": "C4231851", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of D-glucosyl-N-acylsphingosine glucohydrolase activity"}
{"concept_id": "C4231852", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ceramide glucosidase activity"}
{"concept_id": "C4231853", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of beta-glucosylceramidase activity"}
{"concept_id": "C4231854", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of beta-glucocerebrosidase activity"}
{"concept_id": "C4231855", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of beta-D-glucocerebrosidase activity"}
{"concept_id": "C4231856", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acid beta-glucosidase activity"}
{"concept_id": "C4231858", "aliases": ["upregulation of RNR", "up-regulation of RNR"], "types": ["T044"], "canonical_name": "up regulation of RNR"}
{"concept_id": "C4231859", "aliases": ["up-regulation of ribonucleotide diphosphate reductase activity", "upregulation of ribonucleotide diphosphate reductase activity"], "types": ["T044"], "canonical_name": "up regulation of ribonucleotide diphosphate reductase activity"}
{"concept_id": "C4231860", "aliases": ["up-regulation of ribonucleoside-diphosphate reductase activity", "upregulation of ribonucleoside-diphosphate reductase activity"], "types": ["T044"], "canonical_name": "up regulation of ribonucleoside-diphosphate reductase activity"}
{"concept_id": "C4231861", "aliases": ["up-regulation of ribonucleoside 5'-diphosphate reductase activity", "upregulation of ribonucleoside 5'-diphosphate reductase activity"], "types": ["T044"], "canonical_name": "up regulation of ribonucleoside 5'-diphosphate reductase activity"}
{"concept_id": "C4231862", "aliases": ["up-regulation of purine/pyrimidine nucleoside diphosphate reduction", "upregulation of purine/pyrimidine nucleoside diphosphate reduction"], "types": ["T044"], "canonical_name": "up regulation of purine/pyrimidine nucleoside diphosphate reduction"}
{"concept_id": "C4231863", "aliases": ["upregulation of nucleoside diphosphate reductase activity", "up-regulation of nucleoside diphosphate reductase activity"], "types": ["T044"], "canonical_name": "up regulation of nucleoside diphosphate reductase activity"}
{"concept_id": "C4231864", "aliases": ["upregulation of class III ribonucleotide reductase activity", "up-regulation of class III ribonucleotide reductase activity"], "types": ["T044"], "canonical_name": "up regulation of class III ribonucleotide reductase activity"}
{"concept_id": "C4231865", "aliases": ["upregulation of class II ribonucleotide reductase activity", "up-regulation of class II ribonucleotide reductase activity"], "types": ["T044"], "canonical_name": "up regulation of class II ribonucleotide reductase activity"}
{"concept_id": "C4231866", "aliases": ["up-regulation of class II ribonucleoside-diphosphate reductase activity", "upregulation of class II ribonucleoside-diphosphate reductase activity"], "types": ["T044"], "canonical_name": "up regulation of class II ribonucleoside-diphosphate reductase activity"}
{"concept_id": "C4231867", "aliases": ["up-regulation of class I ribonucleotide reductase activity", "upregulation of class I ribonucleotide reductase activity"], "types": ["T044"], "canonical_name": "up regulation of class I ribonucleotide reductase activity"}
{"concept_id": "C4231868", "aliases": ["up-regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity", "upregulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity"], "types": ["T044"], "canonical_name": "up regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231869", "aliases": ["upregulation of aerobic non-heme iron-dependent ribonucleotide reductase activity", "up-regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity"], "types": ["T044"], "canonical_name": "up regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231870", "aliases": ["upregulation of adenosylcobalamin-dependent ribonucleotide reductase activity", "up-regulation of adenosylcobalamin-dependent ribonucleotide reductase activity"], "types": ["T044"], "canonical_name": "up regulation of adenosylcobalamin-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231871", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of RNR"}
{"concept_id": "C4231872", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ribonucleotide diphosphate reductase activity"}
{"concept_id": "C4231873", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ribonucleoside 5'-diphosphate reductase activity"}
{"concept_id": "C4231874", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of purine/pyrimidine nucleoside diphosphate reduction"}
{"concept_id": "C4231875", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of nucleoside diphosphate reductase activity"}
{"concept_id": "C4231876", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of class III ribonucleotide reductase activity"}
{"concept_id": "C4231877", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of class II ribonucleotide reductase activity"}
{"concept_id": "C4231878", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of class II ribonucleoside-diphosphate reductase activity"}
{"concept_id": "C4231879", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of class I ribonucleotide reductase activity"}
{"concept_id": "C4231880", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231881", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231882", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of adenosylcobalamin-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231883", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNR"}
{"concept_id": "C4231884", "aliases": [], "types": ["T044"], "canonical_name": "activation of ribonucleotide diphosphate reductase activity"}
{"concept_id": "C4231885", "aliases": [], "types": ["T044"], "canonical_name": "activation of ribonucleoside-diphosphate reductase activity"}
{"concept_id": "C4231886", "aliases": [], "types": ["T044"], "canonical_name": "activation of ribonucleoside 5'-diphosphate reductase activity"}
{"concept_id": "C4231887", "aliases": [], "types": ["T044"], "canonical_name": "activation of purine/pyrimidine nucleoside diphosphate reduction"}
{"concept_id": "C4231888", "aliases": [], "types": ["T044"], "canonical_name": "activation of nucleoside diphosphate reductase activity"}
{"concept_id": "C4231889", "aliases": [], "types": ["T044"], "canonical_name": "activation of class III ribonucleotide reductase activity"}
{"concept_id": "C4231890", "aliases": [], "types": ["T044"], "canonical_name": "activation of class II ribonucleotide reductase activity"}
{"concept_id": "C4231891", "aliases": [], "types": ["T044"], "canonical_name": "activation of class II ribonucleoside-diphosphate reductase activity"}
{"concept_id": "C4231892", "aliases": [], "types": ["T044"], "canonical_name": "activation of class I ribonucleotide reductase activity"}
{"concept_id": "C4231893", "aliases": [], "types": ["T044"], "canonical_name": "activation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231894", "aliases": [], "types": ["T044"], "canonical_name": "activation of aerobic non-heme iron-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231895", "aliases": [], "types": ["T044"], "canonical_name": "activation of adenosylcobalamin-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231896", "aliases": [], "types": ["T044"], "canonical_name": "regulation of RNR"}
{"concept_id": "C4231897", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ribonucleotide reductase activity"}
{"concept_id": "C4231898", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ribonucleoside 5'-diphosphate reductase activity"}
{"concept_id": "C4231899", "aliases": [], "types": ["T044"], "canonical_name": "regulation of purine/pyrimidine nucleoside diphosphate reduction"}
{"concept_id": "C4231900", "aliases": [], "types": ["T044"], "canonical_name": "regulation of nucleoside diphosphate reductase activity"}
{"concept_id": "C4231901", "aliases": [], "types": ["T044"], "canonical_name": "regulation of class III ribonucleotide reductase activity"}
{"concept_id": "C4231902", "aliases": [], "types": ["T044"], "canonical_name": "regulation of class II ribonucleotide reductase activity"}
{"concept_id": "C4231903", "aliases": [], "types": ["T044"], "canonical_name": "regulation of class II ribonucleoside-diphosphate reductase activity"}
{"concept_id": "C4231904", "aliases": [], "types": ["T044"], "canonical_name": "regulation of class I ribonucleotide reductase activity"}
{"concept_id": "C4231905", "aliases": [], "types": ["T044"], "canonical_name": "regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231906", "aliases": [], "types": ["T044"], "canonical_name": "regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231907", "aliases": [], "types": ["T044"], "canonical_name": "regulation of adenosylcobalamin-dependent ribonucleotide reductase activity"}
{"concept_id": "C4231908", "aliases": [], "types": ["T043"], "canonical_name": "activation of lateral attachment of mitotic spindle microtubules to kinetochore"}
{"concept_id": "C4231935", "aliases": [], "types": ["T039"], "canonical_name": "activation of pulmonary blood vessel remodeling"}
{"concept_id": "C4231936", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of pulmonary blood vessel remodeling"}
{"concept_id": "C4231937", "aliases": [], "types": ["T026"], "canonical_name": "integral to lysosomal membrane"}
{"concept_id": "C4231938", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptosome formation"}
{"concept_id": "C4231939", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptosome assembly"}
{"concept_id": "C4231940", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosome formation"}
{"concept_id": "C4231941", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosome assembly"}
{"concept_id": "C4231942", "aliases": ["up-regulation of GNRP", "upregulation of GNRP"], "types": ["T044"], "canonical_name": "up regulation of GNRP"}
{"concept_id": "C4231943", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of GNRP"}
{"concept_id": "C4231944", "aliases": [], "types": ["T044"], "canonical_name": "activation of guanyl-nucleotide releasing factor"}
{"concept_id": "C4231945", "aliases": [], "types": ["T044"], "canonical_name": "activation of guanyl-nucleotide release factor activity"}
{"concept_id": "C4231946", "aliases": [], "types": ["T044"], "canonical_name": "activation of guanyl-nucleotide exchange factor activity"}
{"concept_id": "C4231947", "aliases": [], "types": ["T044"], "canonical_name": "activation of GNRP"}
{"concept_id": "C4231948", "aliases": [], "types": ["T044"], "canonical_name": "activation of GEF"}
{"concept_id": "C4231949", "aliases": [], "types": ["T044"], "canonical_name": "activation of GDS"}
{"concept_id": "C4231950", "aliases": [], "types": ["T044"], "canonical_name": "activation of GDP-dissociation stimulator activity"}
{"concept_id": "C4231951", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of GNRP"}
{"concept_id": "C4231952", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of guanyl-nucleotide releasing factor"}
{"concept_id": "C4231953", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of guanyl-nucleotide release factor activity"}
{"concept_id": "C4231954", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of guanyl-nucleotide exchange factor activity"}
{"concept_id": "C4231955", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of GNRP"}
{"concept_id": "C4231956", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of GEF"}
{"concept_id": "C4231957", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of GDS"}
{"concept_id": "C4231958", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of GDP-dissociation stimulator activity"}
{"concept_id": "C4231959", "aliases": ["downregulation of GNRP", "down-regulation of GNRP"], "types": ["T044"], "canonical_name": "down regulation of GNRP"}
{"concept_id": "C4231960", "aliases": [], "types": ["T044"], "canonical_name": "regulation of GNRP"}
{"concept_id": "C4231961", "aliases": ["activation of apolipoprotein A-I-mediated signalling pathway"], "types": ["T044"], "canonical_name": "activation of apolipoprotein A-I-mediated signaling pathway"}
{"concept_id": "C4231962", "aliases": ["inhibition of apolipoprotein A-I-mediated signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of apolipoprotein A-I-mediated signaling pathway"}
{"concept_id": "C4231963", "aliases": [], "types": ["T043"], "canonical_name": "activation of parkin-mediated mitophagy in response to mitochondrial depolarization"}
{"concept_id": "C4231964", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of parkin-mediated mitophagy in response to mitochondrial depolarization"}
{"concept_id": "C4231965", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptonemal complex formation"}
{"concept_id": "C4231966", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptonemal complex assembly"}
{"concept_id": "C4231967", "aliases": [], "types": ["T044"], "canonical_name": "activation of bioluminescence"}
{"concept_id": "C4231968", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bioluminescence"}
{"concept_id": "C4231969", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitochondrial translational elongation"}
{"concept_id": "C4231970", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitochondrial translation elongation"}
{"concept_id": "C4231971", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mitochondrial translational elongation"}
{"concept_id": "C4231972", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mitochondrial translation elongation"}
{"concept_id": "C4231973", "aliases": [], "types": ["T043"], "canonical_name": "activation of cerebellar neuron development"}
{"concept_id": "C4231974", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cerebellar neuron development"}
{"concept_id": "C4231989", "aliases": [], "types": ["T043"], "canonical_name": "activation of tight junction disassembly"}
{"concept_id": "C4231990", "aliases": [], "types": ["T043"], "canonical_name": "activation of occluding junction disassembly"}
{"concept_id": "C4231991", "aliases": [], "types": ["T043"], "canonical_name": "activation of occluding cell junction disassembly"}
{"concept_id": "C4231993", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of tight junction disassembly"}
{"concept_id": "C4231994", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of occluding junction disassembly"}
{"concept_id": "C4231995", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of occluding cell junction disassembly"}
{"concept_id": "C4231999", "aliases": [], "types": ["T042"], "canonical_name": "allantoic bud development"}
{"concept_id": "C4232000", "aliases": [], "types": ["T044"], "canonical_name": "activation of canonical Wnt-activated signaling pathway involved in heart development"}
{"concept_id": "C4232001", "aliases": [], "types": ["T044"], "canonical_name": "activation of canonical Wnt signaling pathway involved in heart development"}
{"concept_id": "C4232002", "aliases": ["activation of canonical Wnt receptor signalling pathway involved in heart development"], "types": ["T039"], "canonical_name": "activation of canonical Wnt receptor signaling pathway involved in heart development"}
{"concept_id": "C4232003", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of canonical Wnt-activated signaling pathway involved in heart development"}
{"concept_id": "C4232004", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of canonical Wnt signaling pathway involved in heart development"}
{"concept_id": "C4232005", "aliases": ["inhibition of canonical Wnt receptor signalling pathway involved in heart development"], "types": ["T043"], "canonical_name": "inhibition of canonical Wnt receptor signaling pathway involved in heart development"}
{"concept_id": "C4232006", "aliases": [], "types": ["T043"], "canonical_name": "activation of VSMC differentiation"}
{"concept_id": "C4232007", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular smooth muscle cell differentiation"}
{"concept_id": "C4232008", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular associated smooth muscle cell differentiation"}
{"concept_id": "C4232009", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of VSMC differentiation"}
{"concept_id": "C4232010", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vascular smooth muscle cell differentiation"}
{"concept_id": "C4232011", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vascular associated smooth muscle cell differentiation"}
{"concept_id": "C4232012", "aliases": [], "types": ["T043"], "canonical_name": "activation of cardioblast proliferation"}
{"concept_id": "C4232013", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardioblast proliferation"}
{"concept_id": "C4232014", "aliases": [], "types": ["T044"], "canonical_name": "sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232015", "aliases": [], "types": ["T044"], "canonical_name": "sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232016", "aliases": [], "types": ["T044"], "canonical_name": "plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232017", "aliases": [], "types": ["T044"], "canonical_name": "calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232018", "aliases": [], "types": ["T044"], "canonical_name": "calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232019", "aliases": [], "types": ["T044"], "canonical_name": "calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232020", "aliases": [], "types": ["T044"], "canonical_name": "dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232021", "aliases": [], "types": ["T044"], "canonical_name": "plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232022", "aliases": [], "types": ["T044"], "canonical_name": "calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232023", "aliases": [], "types": ["T044"], "canonical_name": "calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232024", "aliases": [], "types": ["T044"], "canonical_name": "calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration"}
{"concept_id": "C4232025", "aliases": [], "types": ["T045"], "canonical_name": "activation of BER"}
{"concept_id": "C4232026", "aliases": [], "types": ["T045"], "canonical_name": "activation of base-excision repair"}
{"concept_id": "C4232027", "aliases": ["inhibition of base-excision repair"], "types": ["T045"], "canonical_name": "inhibition of BER"}
{"concept_id": "C4232028", "aliases": ["up-regulation of metalloproteinase activity", "upregulation of metalloproteinase activity"], "types": ["T044"], "canonical_name": "up regulation of metalloproteinase activity"}
{"concept_id": "C4232029", "aliases": ["up-regulation of metalloprotease activity", "upregulation of metalloprotease activity"], "types": ["T044"], "canonical_name": "up regulation of metalloprotease activity"}
{"concept_id": "C4232030", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of metalloproteinase activity"}
{"concept_id": "C4232031", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of metalloprotease activity"}
{"concept_id": "C4232032", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloproteinase activity"}
{"concept_id": "C4232033", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloprotease activity"}
{"concept_id": "C4232034", "aliases": [], "types": ["T044"], "canonical_name": "activation of metallopeptidase activity"}
{"concept_id": "C4232035", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of metalloproteinase activity"}
{"concept_id": "C4232036", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of metalloprotease activity"}
{"concept_id": "C4232037", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloproteinase activity"}
{"concept_id": "C4232038", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloprotease activity"}
{"concept_id": "C4232039", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metallopeptidase activity"}
{"concept_id": "C4232040", "aliases": ["downregulation of metalloproteinase activity", "down-regulation of metalloproteinase activity"], "types": ["T044"], "canonical_name": "down regulation of metalloproteinase activity"}
{"concept_id": "C4232041", "aliases": ["downregulation of metalloprotease activity", "down-regulation of metalloprotease activity"], "types": ["T044"], "canonical_name": "down regulation of metalloprotease activity"}
{"concept_id": "C4232042", "aliases": [], "types": ["T044"], "canonical_name": "regulation of metalloproteinase activity"}
{"concept_id": "C4232043", "aliases": [], "types": ["T044"], "canonical_name": "regulation of metalloprotease activity"}
{"concept_id": "C4232044", "aliases": [], "types": ["T043"], "canonical_name": "activation of Schwann cell proliferation involved in axon regeneration"}
{"concept_id": "C4232045", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Schwann cell proliferation involved in axon regeneration"}
{"concept_id": "C4232046", "aliases": ["activation of regeneration of epithelium"], "types": ["T042"], "canonical_name": "activation of epithelium regeneration"}
{"concept_id": "C4232047", "aliases": ["inhibition of regeneration of epithelium"], "types": ["T042"], "canonical_name": "inhibition of epithelium regeneration"}
{"concept_id": "C4232048", "aliases": [], "types": ["T042"], "canonical_name": "octaval VIII placode development"}
{"concept_id": "C4232049", "aliases": [], "types": ["T042"], "canonical_name": "octaval placode development"}
{"concept_id": "C4232050", "aliases": [], "types": ["T042"], "canonical_name": "ear/otic placode development"}
{"concept_id": "C4232051", "aliases": [], "types": ["T042"], "canonical_name": "ear placode development"}
{"concept_id": "C4232052", "aliases": [], "types": ["T042"], "canonical_name": "auditory placode development"}
{"concept_id": "C4232053", "aliases": [], "types": ["T043"], "canonical_name": "initial autophagic vacuole organization"}
{"concept_id": "C4232054", "aliases": [], "types": ["T039"], "canonical_name": "activation of antifungal innate immune response"}
{"concept_id": "C4232055", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of antifungal innate immune response"}
{"concept_id": "C4232056", "aliases": [], "types": ["T043"], "canonical_name": "activation of membrane repolarization during cardiac muscle cell action potential"}
{"concept_id": "C4232057", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane repolarization during cardiac muscle cell action potential"}
{"concept_id": "C4232058", "aliases": [], "types": ["T043"], "canonical_name": "activation of membrane depolarization during AV node cell action potential"}
{"concept_id": "C4232059", "aliases": [], "types": ["T043"], "canonical_name": "activation of membrane depolarization during AV node cardiac muscle cell action potential"}
{"concept_id": "C4232060", "aliases": [], "types": ["T042"], "canonical_name": "activation of membrane depolarization during atrioventricular node cardiac muscle cell action potential"}
{"concept_id": "C4232061", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane depolarization during AV node cell action potential"}
{"concept_id": "C4232062", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane depolarization during AV node cardiac muscle cell action potential"}
{"concept_id": "C4232063", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane depolarization during atrioventricular node cardiac muscle cell action potential"}
{"concept_id": "C4232064", "aliases": ["upregulation of ventricular repolarization", "up-regulation of ventricular repolarization"], "types": ["T043"], "canonical_name": "up regulation of ventricular repolarization"}
{"concept_id": "C4232065", "aliases": ["up-regulation of regulation of ventricular cardiac muscle repolarization", "upregulation of regulation of ventricular cardiac muscle repolarization"], "types": ["T043"], "canonical_name": "up regulation of regulation of ventricular cardiac muscle repolarization"}
{"concept_id": "C4232066", "aliases": ["upregulation of electrocardiogram T wave", "up-regulation of electrocardiogram T wave"], "types": ["T043"], "canonical_name": "up regulation of electrocardiogram T wave"}
{"concept_id": "C4232067", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ventricular repolarization"}
{"concept_id": "C4232068", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of regulation of ventricular cardiac muscle repolarization"}
{"concept_id": "C4232069", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of electrocardiogram T wave"}
{"concept_id": "C4232070", "aliases": [], "types": ["T043"], "canonical_name": "activation of ventricular repolarization"}
{"concept_id": "C4232071", "aliases": [], "types": ["T043"], "canonical_name": "activation of regulation of ventricular cardiac muscle repolarization"}
{"concept_id": "C4232072", "aliases": [], "types": ["T043"], "canonical_name": "activation of membrane repolarization during ventricular cardiac muscle cell action potential"}
{"concept_id": "C4232073", "aliases": [], "types": ["T043"], "canonical_name": "activation of electrocardiogram T wave"}
{"concept_id": "C4232074", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ventricular repolarization"}
{"concept_id": "C4232075", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of regulation of ventricular cardiac muscle repolarization"}
{"concept_id": "C4232076", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of electrocardiogram T wave"}
{"concept_id": "C4232077", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ventricular repolarization"}
{"concept_id": "C4232078", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of regulation of ventricular cardiac muscle repolarization"}
{"concept_id": "C4232079", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane repolarization during ventricular cardiac muscle cell action potential"}
{"concept_id": "C4232080", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of electrocardiogram T wave"}
{"concept_id": "C4232081", "aliases": ["down-regulation of ventricular repolarization", "downregulation of ventricular repolarization"], "types": ["T043"], "canonical_name": "down regulation of ventricular repolarization"}
{"concept_id": "C4232082", "aliases": ["downregulation of regulation of ventricular cardiac muscle repolarization", "down-regulation of regulation of ventricular cardiac muscle repolarization"], "types": ["T043"], "canonical_name": "down regulation of regulation of ventricular cardiac muscle repolarization"}
{"concept_id": "C4232083", "aliases": ["down-regulation of electrocardiogram T wave", "downregulation of electrocardiogram T wave"], "types": ["T043"], "canonical_name": "down regulation of electrocardiogram T wave"}
{"concept_id": "C4232084", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ventricular repolarization"}
{"concept_id": "C4232085", "aliases": [], "types": ["T043"], "canonical_name": "regulation of regulation of ventricular cardiac muscle repolarization"}
{"concept_id": "C4232086", "aliases": [], "types": ["T042"], "canonical_name": "regulation of electrocardiogram T wave"}
{"concept_id": "C4232087", "aliases": ["up-regulation of TRS", "upregulation of TRS"], "types": ["T044"], "canonical_name": "up regulation of TRS"}
{"concept_id": "C4232088", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of TRS"}
{"concept_id": "C4232089", "aliases": [], "types": ["T044"], "canonical_name": "activation of TRS"}
{"concept_id": "C4232090", "aliases": [], "types": ["T044"], "canonical_name": "activation of threonyl-tRNA synthetase activity"}
{"concept_id": "C4232091", "aliases": [], "types": ["T044"], "canonical_name": "activation of threonyl-transfer RNA synthetase activity"}
{"concept_id": "C4232092", "aliases": [], "types": ["T044"], "canonical_name": "activation of threonyl-transfer ribonucleic acid synthetase activity"}
{"concept_id": "C4232093", "aliases": [], "types": ["T044"], "canonical_name": "activation of threonyl-transfer ribonucleate synthetase activity"}
{"concept_id": "C4232094", "aliases": [], "types": ["T044"], "canonical_name": "activation of threonyl ribonucleic synthetase activity"}
{"concept_id": "C4232095", "aliases": [], "types": ["T044"], "canonical_name": "activation of threonine-tRNA ligase activity"}
{"concept_id": "C4232096", "aliases": [], "types": ["T044"], "canonical_name": "activation of threonine-transfer ribonucleate synthetase activity"}
{"concept_id": "C4232097", "aliases": [], "types": ["T044"], "canonical_name": "activation of threonine translase activity"}
{"concept_id": "C4232098", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-threonine:tRNAThr ligase (AMP-forming)"}
{"concept_id": "C4232099", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of TRS"}
{"concept_id": "C4232100", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of TRS"}
{"concept_id": "C4232101", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of threonyl-tRNA synthetase activity"}
{"concept_id": "C4232102", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of threonyl-transfer RNA synthetase activity"}
{"concept_id": "C4232103", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of threonyl-transfer ribonucleic acid synthetase activity"}
{"concept_id": "C4232104", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of threonyl-transfer ribonucleate synthetase activity"}
{"concept_id": "C4232105", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of threonyl ribonucleic synthetase activity"}
{"concept_id": "C4232106", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of threonine-tRNA ligase activity"}
{"concept_id": "C4232107", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of threonine-transfer ribonucleate synthetase activity"}
{"concept_id": "C4232108", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of threonine translase activity"}
{"concept_id": "C4232109", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-threonine:tRNAThr ligase (AMP-forming)"}
{"concept_id": "C4232110", "aliases": ["downregulation of TRS", "down-regulation of TRS"], "types": ["T044"], "canonical_name": "down regulation of TRS"}
{"concept_id": "C4232111", "aliases": [], "types": ["T044"], "canonical_name": "regulation of TRS"}
{"concept_id": "C4232112", "aliases": [], "types": ["T044"], "canonical_name": "activation of MetRS activity"}
{"concept_id": "C4232113", "aliases": [], "types": ["T044"], "canonical_name": "activation of methionyl-tRNA synthetase activity"}
{"concept_id": "C4232114", "aliases": [], "types": ["T044"], "canonical_name": "activation of methionyl-transfer RNA synthetase activity"}
{"concept_id": "C4232115", "aliases": [], "types": ["T044"], "canonical_name": "activation of methionyl-transfer ribonucleic acid synthetase activity"}
{"concept_id": "C4232116", "aliases": [], "types": ["T044"], "canonical_name": "activation of methionyl-transfer ribonucleate synthetase activity"}
{"concept_id": "C4232117", "aliases": [], "types": ["T044"], "canonical_name": "activation of methionine-tRNA ligase activity"}
{"concept_id": "C4232118", "aliases": [], "types": ["T044"], "canonical_name": "activation of methionine translase activity"}
{"concept_id": "C4232119", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-methionine:tRNAMet ligase (AMP-forming)"}
{"concept_id": "C4232120", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of MetRS activity"}
{"concept_id": "C4232121", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methionyl-tRNA synthetase activity"}
{"concept_id": "C4232122", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methionyl-transfer RNA synthetase activity"}
{"concept_id": "C4232123", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methionyl-transfer ribonucleic acid synthetase activity"}
{"concept_id": "C4232124", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methionyl-transfer ribonucleate synthetase activity"}
{"concept_id": "C4232125", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methionine-tRNA ligase activity"}
{"concept_id": "C4232126", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of methionine translase activity"}
{"concept_id": "C4232127", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-methionine:tRNAMet ligase (AMP-forming)"}
{"concept_id": "C4232128", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-isoleucine:tRNAIle ligase (AMP-forming)"}
{"concept_id": "C4232129", "aliases": [], "types": ["T044"], "canonical_name": "activation of isoleucyl-tRNA synthetase activity"}
{"concept_id": "C4232130", "aliases": [], "types": ["T044"], "canonical_name": "activation of isoleucyl-transfer RNA synthetase activity"}
{"concept_id": "C4232131", "aliases": [], "types": ["T044"], "canonical_name": "activation of isoleucyl-transfer ribonucleate synthetase activity"}
{"concept_id": "C4232132", "aliases": [], "types": ["T044"], "canonical_name": "activation of isoleucine-tRNA synthetase activity"}
{"concept_id": "C4232133", "aliases": [], "types": ["T044"], "canonical_name": "activation of isoleucine-tRNA ligase activity"}
{"concept_id": "C4232134", "aliases": [], "types": ["T044"], "canonical_name": "activation of isoleucine-transfer RNA ligase activity"}
{"concept_id": "C4232135", "aliases": [], "types": ["T044"], "canonical_name": "activation of isoleucine translase activity"}
{"concept_id": "C4232136", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-isoleucine:tRNAIle ligase (AMP-forming)"}
{"concept_id": "C4232137", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoleucyl-tRNA synthetase activity"}
{"concept_id": "C4232138", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoleucyl-transfer RNA synthetase activity"}
{"concept_id": "C4232139", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoleucyl-transfer ribonucleate synthetase activity"}
{"concept_id": "C4232140", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoleucine-tRNA synthetase activity"}
{"concept_id": "C4232141", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoleucine-tRNA ligase activity"}
{"concept_id": "C4232142", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoleucine-transfer RNA ligase activity"}
{"concept_id": "C4232143", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of isoleucine translase activity"}
{"concept_id": "C4232144", "aliases": ["upregulation of 'de novo' NAD biosynthetic process from tryptophan", "up regulation of 'de novo' NAD biosynthetic process from tryptophan", "up-regulation of 'de novo' NAD biosynthetic process from tryptophan", "upregulation of de novo NAD biosynthetic process from tryptophan", "up-regulation of de novo NAD biosynthetic process from tryptophan"], "types": ["T044"], "canonical_name": "up regulation of de novo NAD biosynthetic process from tryptophan"}
{"concept_id": "C4232146", "aliases": ["activation of de novo NAD biosynthetic process from tryptophan"], "types": ["T044"], "canonical_name": "activation of 'de novo' NAD biosynthetic process from tryptophan"}
{"concept_id": "C4232148", "aliases": ["inhibition of de novo NAD biosynthetic process from tryptophan"], "types": ["T044"], "canonical_name": "inhibition of 'de novo' NAD biosynthetic process from tryptophan"}
{"concept_id": "C4232150", "aliases": ["regulation of de novo NAD biosynthetic process from tryptophan"], "types": ["T044"], "canonical_name": "regulation of 'de novo' NAD biosynthetic process from tryptophan", "definition": "Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]"}
{"concept_id": "C4232151", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-lysine import into cell"}
{"concept_id": "C4232152", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-lysine import into cell"}
{"concept_id": "C4232153", "aliases": [], "types": ["T043"], "canonical_name": "activation of epithelial to mesenchymal transition involved in endocardial cushion formation"}
{"concept_id": "C4232154", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of epithelial to mesenchymal transition involved in endocardial cushion formation"}
{"concept_id": "C4232155", "aliases": ["upregulation of electrocardiogram QRS complex", "up-regulation of electrocardiogram QRS complex"], "types": ["T043"], "canonical_name": "up regulation of electrocardiogram QRS complex"}
{"concept_id": "C4232156", "aliases": ["upregulation of atrial repolarization", "up-regulation of atrial repolarization"], "types": ["T043"], "canonical_name": "up regulation of atrial repolarization"}
{"concept_id": "C4232157", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of electrocardiogram QRS complex"}
{"concept_id": "C4232158", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of atrial repolarization"}
{"concept_id": "C4232159", "aliases": [], "types": ["T043"], "canonical_name": "activation of membrane repolarization during atrial cardiac muscle cell action potential"}
{"concept_id": "C4232160", "aliases": [], "types": ["T043"], "canonical_name": "activation of electrocardiogram QRS complex"}
{"concept_id": "C4232161", "aliases": [], "types": ["T043"], "canonical_name": "activation of atrial repolarization"}
{"concept_id": "C4232162", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of electrocardiogram QRS complex"}
{"concept_id": "C4232163", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of atrial repolarization"}
{"concept_id": "C4232164", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane repolarization during atrial cardiac muscle cell action potential"}
{"concept_id": "C4232165", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of electrocardiogram QRS complex"}
{"concept_id": "C4232166", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of atrial repolarization"}
{"concept_id": "C4232167", "aliases": ["down-regulation of electrocardiogram QRS complex", "downregulation of electrocardiogram QRS complex"], "types": ["T043"], "canonical_name": "down regulation of electrocardiogram QRS complex"}
{"concept_id": "C4232168", "aliases": ["downregulation of atrial repolarization", "down-regulation of atrial repolarization"], "types": ["T043"], "canonical_name": "down regulation of atrial repolarization"}
{"concept_id": "C4232169", "aliases": [], "types": ["T042"], "canonical_name": "regulation of electrocardiogram QRS complex"}
{"concept_id": "C4232170", "aliases": [], "types": ["T042"], "canonical_name": "regulation of atrial repolarization"}
{"concept_id": "C4232171", "aliases": [], "types": ["T043"], "canonical_name": "activation of leukocyte adhesion to arterial endothelial cell"}
{"concept_id": "C4232172", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of leukocyte adhesion to arterial endothelial cell"}
{"concept_id": "C4232173", "aliases": [], "types": ["T043"], "canonical_name": "activation of leukocyte adhesion to vascular endothelial cell"}
{"concept_id": "C4232174", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of leukocyte adhesion to vascular endothelial cell"}
{"concept_id": "C4232175", "aliases": ["up regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway", "up-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway", "upregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway", "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway", "up regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway", "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway", "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway", "upregulation of dopamine receptor, adenylyl cyclase inhibiting pathway", "up regulation of dopamine receptor, adenylate cyclase inhibiting pathway", "up regulation of dopamine receptor, adenylyl cyclase inhibiting pathway", "up-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway", "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway", "up-regulation of dopamine receptor, adenylate cyclase inhibiting pathway", "upregulation of dopamine receptor, adenylate cyclase inhibiting pathway"], "types": ["T043"], "canonical_name": "up regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway"}
{"concept_id": "C4232177", "aliases": ["activation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway"], "types": ["T043"], "canonical_name": "activation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway"}
{"concept_id": "C4232178", "aliases": [], "types": ["T043"], "canonical_name": "activation of dopamine receptor, adenylyl cyclase inhibiting pathway"}
{"concept_id": "C4232179", "aliases": [], "types": ["T043"], "canonical_name": "activation of dopamine receptor, adenylate cyclase inhibiting pathway"}
{"concept_id": "C4232180", "aliases": [], "types": ["T043"], "canonical_name": "activation of adenylate cyclase-inhibiting dopamine receptor signaling pathway"}
{"concept_id": "C4232182", "aliases": ["inhibition of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway"}
{"concept_id": "C4232183", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of dopamine receptor, adenylyl cyclase inhibiting pathway"}
{"concept_id": "C4232184", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of dopamine receptor, adenylate cyclase inhibiting pathway"}
{"concept_id": "C4232185", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of adenylate cyclase-inhibiting dopamine receptor signaling pathway"}
{"concept_id": "C4232186", "aliases": ["down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway", "down-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway", "downregulation of dopamine receptor, adenylyl cyclase inhibiting pathway", "down regulation of dopamine receptor, adenylyl cyclase inhibiting pathway", "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway", "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway", "downregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway", "down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway", "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway", "down-regulation of dopamine receptor, adenylate cyclase inhibiting pathway", "down regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway", "down regulation of dopamine receptor, adenylate cyclase inhibiting pathway", "down-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway", "downregulation of dopamine receptor, adenylate cyclase inhibiting pathway"], "types": ["T044"], "canonical_name": "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway"}
{"concept_id": "C4232188", "aliases": [], "types": ["T043"], "canonical_name": "activation of endothelial cell activation"}
{"concept_id": "C4232189", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelial cell activation"}
{"concept_id": "C4232190", "aliases": [], "types": ["T044"], "canonical_name": "activation of quinolinate synthesis"}
{"concept_id": "C4232191", "aliases": [], "types": ["T044"], "canonical_name": "activation of quinolinate formation"}
{"concept_id": "C4232192", "aliases": [], "types": ["T044"], "canonical_name": "activation of quinolinate biosynthetic process"}
{"concept_id": "C4232193", "aliases": [], "types": ["T044"], "canonical_name": "activation of quinolinate biosynthesis"}
{"concept_id": "C4232194", "aliases": [], "types": ["T044"], "canonical_name": "activation of quinolinate anabolism"}
{"concept_id": "C4232195", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of quinolinate synthesis"}
{"concept_id": "C4232196", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of quinolinate formation"}
{"concept_id": "C4232197", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of quinolinate biosynthetic process"}
{"concept_id": "C4232198", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of quinolinate biosynthesis"}
{"concept_id": "C4232199", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of quinolinate anabolism"}
{"concept_id": "C4232200", "aliases": ["upregulation of endosome organization and biogenesis", "up-regulation of endosome organization and biogenesis"], "types": ["T043"], "canonical_name": "up regulation of endosome organization and biogenesis"}
{"concept_id": "C4232201", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endosome organization and biogenesis"}
{"concept_id": "C4232202", "aliases": [], "types": ["T043"], "canonical_name": "activation of endosome organization and biogenesis"}
{"concept_id": "C4232203", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endosome organization and biogenesis"}
{"concept_id": "C4232204", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endosome organization and biogenesis"}
{"concept_id": "C4232205", "aliases": ["inhibition of endosome organization"], "types": ["T043"], "canonical_name": "inhibition of endosome organisation"}
{"concept_id": "C4232206", "aliases": ["down-regulation of endosome organization and biogenesis", "downregulation of endosome organization and biogenesis"], "types": ["T043"], "canonical_name": "down regulation of endosome organization and biogenesis"}
{"concept_id": "C4232207", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endosome organization and biogenesis"}
{"concept_id": "C4232208", "aliases": [], "types": ["T045"], "canonical_name": "activation of viral translation"}
{"concept_id": "C4232209", "aliases": [], "types": ["T045"], "canonical_name": "activation of viral protein synthesis"}
{"concept_id": "C4232210", "aliases": [], "types": ["T045"], "canonical_name": "activation of viral protein formation"}
{"concept_id": "C4232211", "aliases": [], "types": ["T045"], "canonical_name": "activation of viral protein biosynthetic process"}
{"concept_id": "C4232212", "aliases": [], "types": ["T045"], "canonical_name": "activation of viral protein biosynthesis"}
{"concept_id": "C4232213", "aliases": [], "types": ["T045"], "canonical_name": "activation of viral protein anabolism"}
{"concept_id": "C4232214", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of viral translation"}
{"concept_id": "C4232215", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of viral protein synthesis"}
{"concept_id": "C4232216", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of viral protein formation"}
{"concept_id": "C4232217", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of viral protein biosynthetic process"}
{"concept_id": "C4232218", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of viral protein biosynthesis"}
{"concept_id": "C4232219", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of viral protein anabolism"}
{"concept_id": "C4232220", "aliases": ["up-regulation of attachment of spindle microtubules to kinetochore during meiosis I", "upregulation of attachment of spindle microtubules to kinetochore during meiosis I"], "types": ["T043"], "canonical_name": "up regulation of attachment of spindle microtubules to kinetochore during meiosis I"}
{"concept_id": "C4232221", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of attachment of spindle microtubules to kinetochore during meiosis I"}
{"concept_id": "C4232222", "aliases": [], "types": ["T043"], "canonical_name": "activation of sister kinetochore mono-orientation"}
{"concept_id": "C4232223", "aliases": [], "types": ["T043"], "canonical_name": "activation of monopolar attachment"}
{"concept_id": "C4232224", "aliases": [], "types": ["T043"], "canonical_name": "activation of attachment of spindle microtubules to kinetochore involved in meiosis I"}
{"concept_id": "C4232225", "aliases": [], "types": ["T043"], "canonical_name": "activation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation"}
{"concept_id": "C4232226", "aliases": [], "types": ["T043"], "canonical_name": "activation of attachment of spindle microtubules to kinetochore during meiosis I"}
{"concept_id": "C4232227", "aliases": [], "types": ["T043"], "canonical_name": "regulation of attachment of spindle microtubules to kinetochore during meiosis I"}
{"concept_id": "C4232228", "aliases": ["upregulation of alpha-tocopherol biosynthetic process", "up-regulation of alpha-tocopherol biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of alpha-tocopherol biosynthetic process"}
{"concept_id": "C4232229", "aliases": ["up-regulation of alpha-tocopherol biosynthesis", "upregulation of alpha-tocopherol biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of alpha-tocopherol biosynthesis"}
{"concept_id": "C4232230", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of alpha-tocopherol biosynthetic process"}
{"concept_id": "C4232231", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of alpha-tocopherol biosynthesis"}
{"concept_id": "C4232232", "aliases": [], "types": ["T044"], "canonical_name": "activation of vitamin E synthesis"}
{"concept_id": "C4232233", "aliases": [], "types": ["T044"], "canonical_name": "activation of vitamin E formation"}
{"concept_id": "C4232234", "aliases": [], "types": ["T044"], "canonical_name": "activation of vitamin E biosynthetic process"}
{"concept_id": "C4232235", "aliases": [], "types": ["T044"], "canonical_name": "activation of vitamin E biosynthesis"}
{"concept_id": "C4232236", "aliases": [], "types": ["T044"], "canonical_name": "activation of vitamin E anabolism"}
{"concept_id": "C4232237", "aliases": [], "types": ["T044"], "canonical_name": "activation of tocopherol biosynthetic process"}
{"concept_id": "C4232238", "aliases": [], "types": ["T044"], "canonical_name": "activation of tocopherol biosynthesis"}
{"concept_id": "C4232239", "aliases": [], "types": ["T044"], "canonical_name": "activation of alpha-tocopherol biosynthetic process"}
{"concept_id": "C4232240", "aliases": [], "types": ["T044"], "canonical_name": "activation of alpha-tocopherol biosynthesis"}
{"concept_id": "C4232241", "aliases": [], "types": ["T044"], "canonical_name": "regulation of alpha-tocopherol biosynthetic process"}
{"concept_id": "C4232242", "aliases": [], "types": ["T044"], "canonical_name": "regulation of alpha-tocopherol biosynthesis"}
{"concept_id": "C4232243", "aliases": [], "types": ["T044"], "canonical_name": "activation of phytol synthesis"}
{"concept_id": "C4232244", "aliases": [], "types": ["T044"], "canonical_name": "activation of phytol formation"}
{"concept_id": "C4232245", "aliases": [], "types": ["T044"], "canonical_name": "activation of phytol biosynthetic process"}
{"concept_id": "C4232246", "aliases": [], "types": ["T044"], "canonical_name": "activation of phytol biosynthesis"}
{"concept_id": "C4232247", "aliases": [], "types": ["T044"], "canonical_name": "activation of phytol anabolism"}
{"concept_id": "C4232248", "aliases": [], "types": ["T043"], "canonical_name": "plastid to vacuolar carboxypeptidase Y vesicle-mediated transport"}
{"concept_id": "C4232249", "aliases": ["upregulation of warburg's respiratory enzyme activity", "up-regulation of warburg's respiratory enzyme activity"], "types": ["T044"], "canonical_name": "up regulation of warburg's respiratory enzyme activity"}
{"concept_id": "C4232250", "aliases": ["up-regulation of indophenolase", "upregulation of indophenolase"], "types": ["T038"], "canonical_name": "up regulation of indophenolase"}
{"concept_id": "C4232251", "aliases": ["up-regulation of indophenol oxidase", "upregulation of indophenol oxidase"], "types": ["T044"], "canonical_name": "up regulation of indophenol oxidase"}
{"concept_id": "C4232252", "aliases": ["up-regulation of ferrocytochrome-c:oxygen oxidoreductase", "upregulation of ferrocytochrome-c:oxygen oxidoreductase"], "types": ["T044"], "canonical_name": "up regulation of ferrocytochrome-c:oxygen oxidoreductase"}
{"concept_id": "C4232253", "aliases": ["up-regulation of ferrocytochrome c oxidase", "upregulation of ferrocytochrome c oxidase"], "types": ["T044"], "canonical_name": "up regulation of ferrocytochrome c oxidase"}
{"concept_id": "C4232254", "aliases": ["upregulation of cytochrome oxidase activity", "up-regulation of cytochrome oxidase activity"], "types": ["T044"], "canonical_name": "up regulation of cytochrome oxidase activity"}
{"concept_id": "C4232255", "aliases": ["upregulation of cytochrome aa3 activity", "up-regulation of cytochrome aa3 activity"], "types": ["T044"], "canonical_name": "up regulation of cytochrome aa3 activity"}
{"concept_id": "C4232256", "aliases": ["upregulation of cytochrome a3 activity", "up-regulation of cytochrome a3 activity"], "types": ["T044"], "canonical_name": "up regulation of cytochrome a3 activity"}
{"concept_id": "C4232257", "aliases": ["upregulation of complex IV (mitochondrial electron transport) activity", "up-regulation of complex IV (mitochondrial electron transport) activity"], "types": ["T044"], "canonical_name": "up regulation of complex IV (mitochondrial electron transport) activity"}
{"concept_id": "C4232258", "aliases": ["upregulation of cbb3-type cytochrome c oxidase", "up-regulation of cbb3-type cytochrome c oxidase"], "types": ["T044"], "canonical_name": "up regulation of cbb3-type cytochrome c oxidase"}
{"concept_id": "C4232259", "aliases": ["upregulation of caa3-type cytochrome c oxidase", "up-regulation of caa3-type cytochrome c oxidase"], "types": ["T044"], "canonical_name": "up regulation of caa3-type cytochrome c oxidase"}
{"concept_id": "C4232260", "aliases": ["up-regulation of ba3-type cytochrome c oxidase", "upregulation of ba3-type cytochrome c oxidase"], "types": ["T044"], "canonical_name": "up regulation of ba3-type cytochrome c oxidase"}
{"concept_id": "C4232261", "aliases": ["up-regulation of aa3-type cytochrome c oxidase", "upregulation of aa3-type cytochrome c oxidase"], "types": ["T044"], "canonical_name": "up regulation of aa3-type cytochrome c oxidase"}
{"concept_id": "C4232262", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of warburg's respiratory enzyme activity"}
{"concept_id": "C4232263", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of indophenolase"}
{"concept_id": "C4232264", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of indophenol oxidase"}
{"concept_id": "C4232265", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ferrocytochrome-c:oxygen oxidoreductase"}
{"concept_id": "C4232266", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ferrocytochrome c oxidase"}
{"concept_id": "C4232267", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cytochrome oxidase activity"}
{"concept_id": "C4232268", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cytochrome aa3 activity"}
{"concept_id": "C4232269", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cytochrome a3 activity"}
{"concept_id": "C4232270", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of complex IV (mitochondrial electron transport) activity"}
{"concept_id": "C4232271", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cbb3-type cytochrome c oxidase"}
{"concept_id": "C4232272", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of caa3-type cytochrome c oxidase"}
{"concept_id": "C4232273", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ba3-type cytochrome c oxidase"}
{"concept_id": "C4232274", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of aa3-type cytochrome c oxidase"}
{"concept_id": "C4232275", "aliases": [], "types": ["T043"], "canonical_name": "activation of warburg's respiratory enzyme activity"}
{"concept_id": "C4232276", "aliases": [], "types": ["T044"], "canonical_name": "activation of NADH cytochrome c oxidase"}
{"concept_id": "C4232277", "aliases": [], "types": ["T044"], "canonical_name": "activation of indophenolase"}
{"concept_id": "C4232278", "aliases": [], "types": ["T044"], "canonical_name": "activation of indophenol oxidase"}
{"concept_id": "C4232279", "aliases": [], "types": ["T044"], "canonical_name": "activation of ferrocytochrome-c:oxygen oxidoreductase"}
{"concept_id": "C4232280", "aliases": [], "types": ["T044"], "canonical_name": "activation of ferrocytochrome c oxidase"}
{"concept_id": "C4232281", "aliases": ["activation of cytochrome-c oxidase activity"], "types": ["T044"], "canonical_name": "activation of cytochrome c oxidase activity"}
{"concept_id": "C4232282", "aliases": [], "types": ["T044"], "canonical_name": "activation of cytochrome oxidase activity"}
{"concept_id": "C4232283", "aliases": [], "types": ["T044"], "canonical_name": "activation of cytochrome aa3 activity"}
{"concept_id": "C4232284", "aliases": [], "types": ["T044"], "canonical_name": "activation of cytochrome a3 activity"}
{"concept_id": "C4232285", "aliases": [], "types": ["T044"], "canonical_name": "activation of complex IV (mitochondrial electron transport) activity"}
{"concept_id": "C4232286", "aliases": [], "types": ["T044"], "canonical_name": "activation of cbb3-type cytochrome c oxidase"}
{"concept_id": "C4232287", "aliases": [], "types": ["T044"], "canonical_name": "activation of caa3-type cytochrome c oxidase"}
{"concept_id": "C4232288", "aliases": [], "types": ["T044"], "canonical_name": "activation of ba3-type cytochrome c oxidase"}
{"concept_id": "C4232289", "aliases": [], "types": ["T044"], "canonical_name": "activation of aa3-type cytochrome c oxidase"}
{"concept_id": "C4232290", "aliases": [], "types": ["T044"], "canonical_name": "regulation of warburg's respiratory enzyme activity"}
{"concept_id": "C4232291", "aliases": [], "types": ["T044"], "canonical_name": "regulation of indophenolase"}
{"concept_id": "C4232292", "aliases": [], "types": ["T044"], "canonical_name": "regulation of indophenol oxidase"}
{"concept_id": "C4232293", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ferrocytochrome-c:oxygen oxidoreductase"}
{"concept_id": "C4232294", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ferrocytochrome c oxidase"}
{"concept_id": "C4232295", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cytochrome oxidase activity"}
{"concept_id": "C4232296", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cytochrome aa3 activity"}
{"concept_id": "C4232297", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cytochrome a3 activity"}
{"concept_id": "C4232298", "aliases": [], "types": ["T044"], "canonical_name": "regulation of complex IV (mitochondrial electron transport) activity"}
{"concept_id": "C4232299", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cbb3-type cytochrome c oxidase"}
{"concept_id": "C4232300", "aliases": [], "types": ["T044"], "canonical_name": "regulation of caa3-type cytochrome c oxidase"}
{"concept_id": "C4232301", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ba3-type cytochrome c oxidase"}
{"concept_id": "C4232302", "aliases": [], "types": ["T044"], "canonical_name": "regulation of aa3-type cytochrome c oxidase"}
{"concept_id": "C4232303", "aliases": [], "types": ["T043"], "canonical_name": "activation of midbrain dopaminergic neuron production"}
{"concept_id": "C4232304", "aliases": [], "types": ["T043"], "canonical_name": "activation of midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4232305", "aliases": [], "types": ["T043"], "canonical_name": "activation of midbrain DA neurogenesis"}
{"concept_id": "C4232306", "aliases": [], "types": ["T043"], "canonical_name": "activation of mDA neuron differentiation"}
{"concept_id": "C4232307", "aliases": [], "types": ["T043"], "canonical_name": "activation of DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4232308", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of midbrain dopaminergic neuron production"}
{"concept_id": "C4232309", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4232310", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of midbrain DA neurogenesis"}
{"concept_id": "C4232311", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mDA neuron differentiation"}
{"concept_id": "C4232312", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4232313", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4232314", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4232315", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-PCP signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4232316", "aliases": [], "types": ["T043"], "canonical_name": "Wnt-PCP signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4232317", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-PCP signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4232318", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4232319", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4232320", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4232321", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4232322", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4232323", "aliases": [], "types": ["T044"], "canonical_name": "non-canonical Wnt-mediated midbrain DA neuron differentiation"}
{"concept_id": "C4232328", "aliases": ["non-canonical Wnt signaling pathway involved in mDA neuron differentiation", "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "non-canonical Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production", "non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation", "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production", "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "non-canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate", "beta-catenin-independent Wnt receptor signaling pathway involved in mDA neuron differentiation", "non-canonical Wnt-activated signaling pathway involved in mDA neuron differentiation", "non-canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis", "non-canonical Wnt receptor signalling pathway involved in mDA neuron differentiation", "non-canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "beta-catenin-independent Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis", "non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "non-canonical Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "non-canonical Wnt receptor signaling pathway involved in mDA neuron differentiation", "non-canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain DA neurogenesis"], "types": ["T044"], "canonical_name": "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "definition": "Any non-canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation. [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183]"}
{"concept_id": "C4232329", "aliases": [], "types": ["T044"], "canonical_name": "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4232330", "aliases": [], "types": ["T044"], "canonical_name": "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4232331", "aliases": [], "types": ["T044"], "canonical_name": "frizzled-1 receptor signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4232332", "aliases": [], "types": ["T044"], "canonical_name": "frizzled-1 receptor signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4232333", "aliases": [], "types": ["T044"], "canonical_name": "frizzled-1 receptor signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4232334", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4232335", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4232336", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-activated signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4232337", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-activated signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4232338", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4232339", "aliases": [], "types": ["T039"], "canonical_name": "activation of protein recruitment"}
{"concept_id": "C4232340", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein positioning"}
{"concept_id": "C4232341", "aliases": ["activation of establishment of protein localization"], "types": ["T039"], "canonical_name": "activation of establishment of protein localisation"}
{"concept_id": "C4232342", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of protein recruitment"}
{"concept_id": "C4232343", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of protein positioning"}
{"concept_id": "C4232344", "aliases": ["inhibition of establishment of protein localization"], "types": ["T043"], "canonical_name": "inhibition of establishment of protein localisation"}
{"concept_id": "C4232345", "aliases": [], "types": ["T042"], "canonical_name": "activation of cardiac ventricle formation"}
{"concept_id": "C4232346", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cardiac ventricle formation"}
{"concept_id": "C4232347", "aliases": ["up-regulation of terminal addition enzyme activity", "upregulation of terminal addition enzyme activity"], "types": ["T044"], "canonical_name": "up regulation of terminal addition enzyme activity"}
{"concept_id": "C4232348", "aliases": ["upregulation of TdT", "up-regulation of TdT"], "types": ["T044"], "canonical_name": "up regulation of TdT"}
{"concept_id": "C4232349", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of terminal addition enzyme activity"}
{"concept_id": "C4232350", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of TdT"}
{"concept_id": "C4232351", "aliases": [], "types": ["T044"], "canonical_name": "activation of terminal transferase activity"}
{"concept_id": "C4232352", "aliases": [], "types": ["T044"], "canonical_name": "activation of terminal deoxyribonucleotidyltransferase activity"}
{"concept_id": "C4232353", "aliases": [], "types": ["T044"], "canonical_name": "activation of terminal deoxynucleotidyltransferase activity"}
{"concept_id": "C4232354", "aliases": [], "types": ["T044"], "canonical_name": "activation of terminal deoxynucleotide transferase activity"}
{"concept_id": "C4232355", "aliases": [], "types": ["T044"], "canonical_name": "activation of terminal addition enzyme activity"}
{"concept_id": "C4232356", "aliases": [], "types": ["T044"], "canonical_name": "activation of TdT"}
{"concept_id": "C4232357", "aliases": [], "types": ["T044"], "canonical_name": "activation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity"}
{"concept_id": "C4232358", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA nucleotidylexotransferase activity"}
{"concept_id": "C4232359", "aliases": [], "types": ["T044"], "canonical_name": "activation of deoxyribonucleic nucleotidyltransferase activity"}
{"concept_id": "C4232360", "aliases": [], "types": ["T044"], "canonical_name": "activation of deoxyribonucleic acid nucleotidyltransferase activity"}
{"concept_id": "C4232361", "aliases": [], "types": ["T044"], "canonical_name": "activation of deoxynucleotidyl terminal transferase activity"}
{"concept_id": "C4232362", "aliases": [], "types": ["T044"], "canonical_name": "activation of addase activity"}
{"concept_id": "C4232363", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of terminal addition enzyme activity"}
{"concept_id": "C4232364", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of TdT"}
{"concept_id": "C4232365", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of terminal transferase activity"}
{"concept_id": "C4232366", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of terminal deoxyribonucleotidyltransferase activity"}
{"concept_id": "C4232367", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of terminal deoxynucleotidyltransferase activity"}
{"concept_id": "C4232368", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of terminal deoxynucleotide transferase activity"}
{"concept_id": "C4232369", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of terminal addition enzyme activity"}
{"concept_id": "C4232370", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of TdT"}
{"concept_id": "C4232371", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity"}
{"concept_id": "C4232372", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA nucleotidylexotransferase activity"}
{"concept_id": "C4232373", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of deoxyribonucleic nucleotidyltransferase activity"}
{"concept_id": "C4232374", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of deoxyribonucleic acid nucleotidyltransferase activity"}
{"concept_id": "C4232375", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of deoxynucleotidyl terminal transferase activity"}
{"concept_id": "C4232376", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of addase activity"}
{"concept_id": "C4232377", "aliases": ["down-regulation of terminal addition enzyme activity", "downregulation of terminal addition enzyme activity"], "types": ["T044"], "canonical_name": "down regulation of terminal addition enzyme activity"}
{"concept_id": "C4232378", "aliases": ["down-regulation of TdT", "downregulation of TdT"], "types": ["T044"], "canonical_name": "down regulation of TdT"}
{"concept_id": "C4232379", "aliases": [], "types": ["T044"], "canonical_name": "regulation of terminal addition enzyme activity"}
{"concept_id": "C4232380", "aliases": [], "types": ["T044"], "canonical_name": "regulation of TdT"}
{"concept_id": "C4232381", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-PCP signaling pathway involved in axon pathfinding"}
{"concept_id": "C4232382", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-PCP signaling pathway involved in axon guidance"}
{"concept_id": "C4232383", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-PCP signaling pathway involved in axon growth cone guidance"}
{"concept_id": "C4232384", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-PCP signaling pathway involved in axon chemotaxis"}
{"concept_id": "C4232385", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway involved in axon pathfinding"}
{"concept_id": "C4232386", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway involved in axon guidance"}
{"concept_id": "C4232387", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway involved in axon growth cone guidance"}
{"concept_id": "C4232388", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-JNK signaling pathway involved in axon chemotaxis"}
{"concept_id": "C4232389", "aliases": [], "types": ["T043"], "canonical_name": "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon growth cone guidance"}
{"concept_id": "C4232390", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon chemotaxis"}
{"concept_id": "C4232391", "aliases": [], "types": ["T044"], "canonical_name": "Wnt signaling pathway, planar cell polarity pathway involved in axon growth cone guidance"}
{"concept_id": "C4232392", "aliases": [], "types": ["T044"], "canonical_name": "Wnt signaling pathway, planar cell polarity pathway involved in axon chemotaxis"}
{"concept_id": "C4232393", "aliases": ["Wnt receptor signalling pathway, planar cell polarity pathway involved in axon growth cone guidance"], "types": ["T043"], "canonical_name": "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon growth cone guidance"}
{"concept_id": "C4232394", "aliases": ["Wnt receptor signalling pathway, planar cell polarity pathway involved in axon chemotaxis"], "types": ["T043"], "canonical_name": "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon chemotaxis"}
{"concept_id": "C4232395", "aliases": [], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in axon growth cone guidance"}
{"concept_id": "C4232396", "aliases": [], "types": ["T043"], "canonical_name": "planar cell polarity pathway involved in axon chemotaxis"}
{"concept_id": "C4232397", "aliases": [], "types": ["T044"], "canonical_name": "PCP pathway involved in axon growth cone guidance"}
{"concept_id": "C4232398", "aliases": [], "types": ["T044"], "canonical_name": "PCP pathway involved in axon chemotaxis"}
{"concept_id": "C4232399", "aliases": [], "types": ["T044"], "canonical_name": "non-canonical Wnt signaling pathway involved in axon pathfinding"}
{"concept_id": "C4232400", "aliases": [], "types": ["T044"], "canonical_name": "non-canonical Wnt signaling pathway involved in axon guidance"}
{"concept_id": "C4232401", "aliases": [], "types": ["T044"], "canonical_name": "non-canonical Wnt signaling pathway involved in axon growth cone guidance"}
{"concept_id": "C4232402", "aliases": [], "types": ["T044"], "canonical_name": "non-canonical Wnt signaling pathway involved in axon chemotaxis"}
{"concept_id": "C4232403", "aliases": ["upregulation of mesencepahalic cell proliferation", "up-regulation of mesencepahalic cell proliferation"], "types": ["T043"], "canonical_name": "up regulation of mesencepahalic cell proliferation"}
{"concept_id": "C4232404", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mesencepahalic cell proliferation"}
{"concept_id": "C4232405", "aliases": [], "types": ["T043"], "canonical_name": "activation of mesencepahalic cell proliferation"}
{"concept_id": "C4232406", "aliases": [], "types": ["T039"], "canonical_name": "activation of cell proliferation in midbrain"}
{"concept_id": "C4232407", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell proliferation in mesencephalon"}
{"concept_id": "C4232408", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mesencepahalic cell proliferation"}
{"concept_id": "C4232409", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mesencepahalic cell proliferation"}
{"concept_id": "C4232410", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cell proliferation in midbrain"}
{"concept_id": "C4232411", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell proliferation in mesencephalon"}
{"concept_id": "C4232412", "aliases": ["down-regulation of mesencepahalic cell proliferation", "downregulation of mesencepahalic cell proliferation"], "types": ["T043"], "canonical_name": "down regulation of mesencepahalic cell proliferation"}
{"concept_id": "C4232413", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mesencepahalic cell proliferation"}
{"concept_id": "C4232414", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of cartilage condensation"}
{"concept_id": "C4232415", "aliases": [], "types": ["T044"], "canonical_name": "Wnt co-receptor, non-canonical pathway"}
{"concept_id": "C4232416", "aliases": [], "types": ["T044"], "canonical_name": "Wnt co-receptor activity, non-canonical signaling"}
{"concept_id": "C4232417", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in Wnt-PCP signaling pathway"}
{"concept_id": "C4232418", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in Wnt-JNK signaling pathway"}
{"concept_id": "C4232419", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway"}
{"concept_id": "C4232420", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway"}
{"concept_id": "C4232421", "aliases": ["coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway"], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway"}
{"concept_id": "C4232422", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in planar cell polarity pathway"}
{"concept_id": "C4232423", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in PCP pathway"}
{"concept_id": "C4232424", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in non-canonical Wnt signaling pathway"}
{"concept_id": "C4232425", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in Wnt-PCP signaling pathway"}
{"concept_id": "C4232426", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in Wnt-JNK signaling pathway"}
{"concept_id": "C4232427", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway"}
{"concept_id": "C4232428", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway"}
{"concept_id": "C4232429", "aliases": ["coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway"], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway"}
{"concept_id": "C4232430", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in planar cell polarity pathway"}
{"concept_id": "C4232431", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in PCP pathway"}
{"concept_id": "C4232432", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in non-canonical Wnt signaling pathway"}
{"concept_id": "C4232433", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor activity involved in Wnt-PCP signaling pathway"}
{"concept_id": "C4232434", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor activity involved in Wnt-JNK signaling pathway"}
{"concept_id": "C4232435", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor activity involved in non-canonical Wnt signaling pathway"}
{"concept_id": "C4232436", "aliases": ["coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin"], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin"}
{"concept_id": "C4232437", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin"}
{"concept_id": "C4232438", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in frizzled-1 receptor signaling pathway"}
{"concept_id": "C4232439", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in canonical Wnt-activated signaling pathway"}
{"concept_id": "C4232440", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in canonical Wnt signaling pathway"}
{"concept_id": "C4232441", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, soluble ligand activity involved in canonical Wnt receptor signaling pathway"}
{"concept_id": "C4232442", "aliases": ["coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin"], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin"}
{"concept_id": "C4232443", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin"}
{"concept_id": "C4232444", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in frizzled-1 receptor signaling pathway"}
{"concept_id": "C4232445", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in canonical Wnt-activated signaling pathway"}
{"concept_id": "C4232446", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in canonical Wnt signaling pathway"}
{"concept_id": "C4232447", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor, insoluble ligand activity involved in canonical Wnt receptor signaling pathway"}
{"concept_id": "C4232448", "aliases": [], "types": ["T044"], "canonical_name": "coreceptor activity involved in frizzled-1 receptor signaling pathway"}
{"concept_id": "C4232449", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitophagy in response to mitochondrial depolarization"}
{"concept_id": "C4232450", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitophagy in response to mitochondrial depolarization"}
{"concept_id": "C4232484", "aliases": ["activation of establishment of macromolecular complex localization to telomere"], "types": ["T043"], "canonical_name": "activation of establishment of macromolecular complex localisation to telomere"}
{"concept_id": "C4232485", "aliases": ["inhibition of establishment of macromolecular complex localization to telomere"], "types": ["T043"], "canonical_name": "inhibition of establishment of macromolecular complex localisation to telomere"}
{"concept_id": "C4232486", "aliases": ["activation of establishment of RNA localization to telomere"], "types": ["T045"], "canonical_name": "activation of establishment of RNA localisation to telomere"}
{"concept_id": "C4232487", "aliases": ["inhibition of establishment of RNA localization to telomere"], "types": ["T043"], "canonical_name": "inhibition of establishment of RNA localisation to telomere"}
{"concept_id": "C4232488", "aliases": [], "types": ["T043"], "canonical_name": "activation of maintenance of telomeric mitotic sister chromatin cohesion"}
{"concept_id": "C4232489", "aliases": [], "types": ["T043"], "canonical_name": "activation of maintenance of sister chromatin cohesion at telomere at mitosis"}
{"concept_id": "C4232490", "aliases": [], "types": ["T043"], "canonical_name": "activation of maintenance of mitotic sister chromatin cohesion at telomere"}
{"concept_id": "C4232491", "aliases": [], "types": ["T043"], "canonical_name": "activation of maintenance of mitotic sister chromatid cohesion, telomeric"}
{"concept_id": "C4232492", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maintenance of telomeric mitotic sister chromatin cohesion"}
{"concept_id": "C4232493", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maintenance of sister chromatin cohesion at telomere at mitosis"}
{"concept_id": "C4232494", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maintenance of mitotic sister chromatin cohesion at telomere"}
{"concept_id": "C4232495", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of maintenance of mitotic sister chromatid cohesion, telomeric"}
{"concept_id": "C4232496", "aliases": [], "types": ["T026"], "canonical_name": "activation of endothelial cell-matrix adhesion via fibronectin"}
{"concept_id": "C4232497", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelial cell-matrix adhesion via fibronectin"}
{"concept_id": "C4232498", "aliases": ["up-regulation of myosin II polymerization or depolymerization", "upregulation of myosin II polymerization or depolymerization"], "types": ["T043"], "canonical_name": "up regulation of myosin II polymerization or depolymerization"}
{"concept_id": "C4232499", "aliases": ["upregulation of myosin II filament assembly or disassembly", "up-regulation of myosin II filament assembly or disassembly"], "types": ["T043"], "canonical_name": "up regulation of myosin II filament assembly or disassembly"}
{"concept_id": "C4232500", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of myosin II polymerization or depolymerization"}
{"concept_id": "C4232501", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of myosin II filament assembly or disassembly"}
{"concept_id": "C4232502", "aliases": [], "types": ["T043"], "canonical_name": "activation of myosin II polymerization or depolymerization"}
{"concept_id": "C4232503", "aliases": ["activation of myosin II filament organization"], "types": ["T043"], "canonical_name": "activation of myosin II filament organisation"}
{"concept_id": "C4232504", "aliases": [], "types": ["T043"], "canonical_name": "activation of myosin II filament assembly or disassembly"}
{"concept_id": "C4232505", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myosin II polymerization or depolymerization"}
{"concept_id": "C4232506", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myosin II filament assembly or disassembly"}
{"concept_id": "C4232507", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myosin II polymerization or depolymerization"}
{"concept_id": "C4232508", "aliases": ["inhibition of myosin II filament organization"], "types": ["T043"], "canonical_name": "inhibition of myosin II filament organisation"}
{"concept_id": "C4232509", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myosin II filament assembly or disassembly"}
{"concept_id": "C4232510", "aliases": ["downregulation of myosin II polymerization or depolymerization", "down-regulation of myosin II polymerization or depolymerization"], "types": ["T043"], "canonical_name": "down regulation of myosin II polymerization or depolymerization"}
{"concept_id": "C4232511", "aliases": ["downregulation of myosin II filament assembly or disassembly", "down-regulation of myosin II filament assembly or disassembly"], "types": ["T043"], "canonical_name": "down regulation of myosin II filament assembly or disassembly"}
{"concept_id": "C4232512", "aliases": [], "types": ["T043"], "canonical_name": "activation of perisinusoidal cell proliferation"}
{"concept_id": "C4232513", "aliases": [], "types": ["T043"], "canonical_name": "activation of Ito cell proliferation"}
{"concept_id": "C4232514", "aliases": [], "types": ["T043"], "canonical_name": "activation of hepatic stellate cell proliferation"}
{"concept_id": "C4232515", "aliases": [], "types": ["T043"], "canonical_name": "activation of hepatic perisinusoidal cell proliferation"}
{"concept_id": "C4232516", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of perisinusoidal cell proliferation"}
{"concept_id": "C4232517", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Ito cell proliferation"}
{"concept_id": "C4232518", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hepatic stellate cell proliferation"}
{"concept_id": "C4232519", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of hepatic perisinusoidal cell proliferation"}
{"concept_id": "C4232520", "aliases": [], "types": ["T044"], "canonical_name": "activation of STAT signalling pathway"}
{"concept_id": "C4232521", "aliases": [], "types": ["T044"], "canonical_name": "activation of STAT cascade"}
{"concept_id": "C4232522", "aliases": [], "types": ["T044"], "canonical_name": "activation of kinase-STAT cascade"}
{"concept_id": "C4232523", "aliases": [], "types": ["T044"], "canonical_name": "activation of kinase activated-STAT cascade"}
{"concept_id": "C4232524", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of STAT signalling pathway"}
{"concept_id": "C4232525", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of STAT cascade"}
{"concept_id": "C4232526", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of kinase-STAT cascade"}
{"concept_id": "C4232527", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of kinase activated-STAT cascade"}
{"concept_id": "C4232528", "aliases": [], "types": ["T043"], "canonical_name": "activation of excitatory synapse formation"}
{"concept_id": "C4232529", "aliases": [], "types": ["T043"], "canonical_name": "activation of excitatory synapse assembly"}
{"concept_id": "C4232530", "aliases": ["inhibition of excitatory synapse formation"], "types": ["T043"], "canonical_name": "inhibition of excitatory synapse assembly"}
{"concept_id": "C4232531", "aliases": [], "types": ["T042"], "canonical_name": "osteocranium development"}
{"concept_id": "C4232532", "aliases": [], "types": ["T042"], "canonical_name": "cranium development"}
{"concept_id": "C4232533", "aliases": [], "types": ["T042"], "canonical_name": "craniofacial development"}
{"concept_id": "C4232534", "aliases": [], "types": ["T042"], "canonical_name": "cranial skeleton development"}
{"concept_id": "C4232535", "aliases": [], "types": ["T044"], "canonical_name": "LRP6 signalosome formation"}
{"concept_id": "C4232536", "aliases": [], "types": ["T044"], "canonical_name": "LRP6 signalosome assembly"}
{"concept_id": "C4232537", "aliases": [], "types": ["T044"], "canonical_name": "23S APC complex disassembly"}
{"concept_id": "C4232538", "aliases": [], "types": ["T044"], "canonical_name": "destruction complex formation"}
{"concept_id": "C4232539", "aliases": [], "types": ["T044"], "canonical_name": "23S APC complex formation"}
{"concept_id": "C4232540", "aliases": [], "types": ["T044"], "canonical_name": "23S APC complex assembly"}
{"concept_id": "C4232541", "aliases": ["up-regulation of TERT-TERC complex formation", "upregulation of TERT-TERC complex formation"], "types": ["T043"], "canonical_name": "up regulation of TERT-TERC complex formation"}
{"concept_id": "C4232542", "aliases": ["upregulation of TERT-TERC complex assembly", "up-regulation of TERT-TERC complex assembly"], "types": ["T043"], "canonical_name": "up regulation of TERT-TERC complex assembly"}
{"concept_id": "C4232543", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of TERT-TERC complex formation"}
{"concept_id": "C4232544", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of TERT-TERC complex assembly"}
{"concept_id": "C4232545", "aliases": [], "types": ["T043"], "canonical_name": "activation of TERT-TERC complex formation"}
{"concept_id": "C4232546", "aliases": [], "types": ["T043"], "canonical_name": "activation of TERT-TERC complex assembly"}
{"concept_id": "C4232547", "aliases": [], "types": ["T043"], "canonical_name": "activation of telomerase catalytic core complex formation"}
{"concept_id": "C4232548", "aliases": [], "types": ["T043"], "canonical_name": "activation of telomerase catalytic core complex assembly"}
{"concept_id": "C4232549", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of TERT-TERC complex formation"}
{"concept_id": "C4232550", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of TERT-TERC complex assembly"}
{"concept_id": "C4232551", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of TERT-TERC complex formation"}
{"concept_id": "C4232552", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of TERT-TERC complex assembly"}
{"concept_id": "C4232553", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of telomerase catalytic core complex formation"}
{"concept_id": "C4232554", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of telomerase catalytic core complex assembly"}
{"concept_id": "C4232555", "aliases": ["down-regulation of TERT-TERC complex formation", "downregulation of TERT-TERC complex formation"], "types": ["T043"], "canonical_name": "down regulation of TERT-TERC complex formation"}
{"concept_id": "C4232556", "aliases": ["down-regulation of TERT-TERC complex assembly", "downregulation of TERT-TERC complex assembly"], "types": ["T043"], "canonical_name": "down regulation of TERT-TERC complex assembly"}
{"concept_id": "C4232557", "aliases": [], "types": ["T043"], "canonical_name": "regulation of TERT-TERC complex formation"}
{"concept_id": "C4232558", "aliases": [], "types": ["T043"], "canonical_name": "regulation of TERT-TERC complex assembly"}
{"concept_id": "C4232559", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of generation of L-type calcium current"}
{"concept_id": "C4232560", "aliases": [], "types": ["T043"], "canonical_name": "activation of generation of L-type calcium current"}
{"concept_id": "C4232561", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of generation of L-type calcium current"}
{"concept_id": "C4232562", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of generation of L-type calcium current"}
{"concept_id": "C4232563", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA ligase activity"}
{"concept_id": "C4232564", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA ligase activity"}
{"concept_id": "C4232565", "aliases": [], "types": ["T043"], "canonical_name": "activation of telomerase RNA localization to Cajal body"}
{"concept_id": "C4232566", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of telomerase RNA localization to Cajal body"}
{"concept_id": "C4232567", "aliases": ["activation of protein localization to Cajal body"], "types": ["T043"], "canonical_name": "activation of protein localisation to Cajal body"}
{"concept_id": "C4232568", "aliases": ["activation of protein localization in Cajal body"], "types": ["T043"], "canonical_name": "activation of protein localisation in Cajal body"}
{"concept_id": "C4232569", "aliases": ["inhibition of protein localization to Cajal body"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to Cajal body"}
{"concept_id": "C4232570", "aliases": ["inhibition of protein localization in Cajal body"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in Cajal body"}
{"concept_id": "C4232571", "aliases": ["telomerase catalytic core complex formation", "TERT-TERC complex formation"], "types": ["T043"], "canonical_name": "telomerase catalytic core complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a telomerase catalytic core complex. [GO_REF:0000079, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4232572", "aliases": [], "types": ["T045"], "canonical_name": "TERT-TERC complex assembly"}
{"concept_id": "C4232573", "aliases": ["ventral tegmental area (Tsai) development", "ventral tegmental nucleus (tsai) development", "ventral tegmental nucleus of tsai development", "ventral tegmental area of tsai development", "a10a development", "ventral tegmentum development", "VTA development"], "types": ["T042"], "canonical_name": "ventral tegmental area development", "definition": "The process whose specific outcome is the progression of a ventral tegmental area (VTA) over time, from its formation to the mature structure. [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26548362]"}
{"concept_id": "C4232574", "aliases": [], "types": ["T042"], "canonical_name": "ventromedial mesencephalic tegmentum development"}
{"concept_id": "C4232575", "aliases": [], "types": ["T042"], "canonical_name": "ventral tegmental nucleus (Rioch) development"}
{"concept_id": "C4232577", "aliases": [], "types": ["T042"], "canonical_name": "ventral brain stem development"}
{"concept_id": "C4232578", "aliases": [], "types": ["T042"], "canonical_name": "tegmentum ventrale development"}
{"concept_id": "C4232579", "aliases": [], "types": ["T042"], "canonical_name": "area tegmentalis ventralis development"}
{"concept_id": "C4232580", "aliases": [], "types": ["T042"], "canonical_name": "area tegmentalis ventralis (Tsai) development"}
{"concept_id": "C4232581", "aliases": ["up-regulation of beta-catenin/T-cell factor complex formation", "upregulation of beta-catenin/T-cell factor complex formation"], "types": ["T043"], "canonical_name": "up regulation of beta-catenin/T-cell factor complex formation"}
{"concept_id": "C4232582", "aliases": ["upregulation of beta-catenin/T-cell factor complex assembly", "up-regulation of beta-catenin/T-cell factor complex assembly"], "types": ["T043"], "canonical_name": "up regulation of beta-catenin/T-cell factor complex assembly"}
{"concept_id": "C4232583", "aliases": ["up-regulation of beta-catenin/lymphoid enhancer binding factor complex formation", "upregulation of beta-catenin/lymphoid enhancer binding factor complex formation"], "types": ["T043"], "canonical_name": "up regulation of beta-catenin/lymphoid enhancer binding factor complex formation"}
{"concept_id": "C4232584", "aliases": ["up-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly", "upregulation of beta-catenin/lymphoid enhancer binding factor complex assembly"], "types": ["T043"], "canonical_name": "up regulation of beta-catenin/lymphoid enhancer binding factor complex assembly"}
{"concept_id": "C4232585", "aliases": ["upregulation of beta-catenin/LEF complex formation", "up-regulation of beta-catenin/LEF complex formation"], "types": ["T043"], "canonical_name": "up regulation of beta-catenin/LEF complex formation"}
{"concept_id": "C4232586", "aliases": ["up-regulation of beta-catenin/LEF complex assembly", "upregulation of beta-catenin/LEF complex assembly"], "types": ["T043"], "canonical_name": "up regulation of beta-catenin/LEF complex assembly"}
{"concept_id": "C4232587", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of beta-catenin/T-cell factor complex formation"}
{"concept_id": "C4232588", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of beta-catenin/T-cell factor complex assembly"}
{"concept_id": "C4232589", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of beta-catenin/lymphoid enhancer binding factor complex formation"}
{"concept_id": "C4232590", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of beta-catenin/lymphoid enhancer binding factor complex assembly"}
{"concept_id": "C4232591", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of beta-catenin/LEF complex formation"}
{"concept_id": "C4232592", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of beta-catenin/LEF complex assembly"}
{"concept_id": "C4232593", "aliases": [], "types": ["T043"], "canonical_name": "activation of beta-catenin/T-cell factor complex formation"}
{"concept_id": "C4232594", "aliases": [], "types": ["T043"], "canonical_name": "activation of beta-catenin/T-cell factor complex assembly"}
{"concept_id": "C4232595", "aliases": [], "types": ["T043"], "canonical_name": "activation of beta-catenin/lymphoid enhancer binding factor complex formation"}
{"concept_id": "C4232596", "aliases": [], "types": ["T043"], "canonical_name": "activation of beta-catenin/lymphoid enhancer binding factor complex assembly"}
{"concept_id": "C4232597", "aliases": [], "types": ["T043"], "canonical_name": "activation of beta-catenin/LEF complex formation"}
{"concept_id": "C4232598", "aliases": [], "types": ["T043"], "canonical_name": "activation of beta-catenin/LEF complex assembly"}
{"concept_id": "C4232599", "aliases": [], "types": ["T043"], "canonical_name": "activation of beta-catenin-TCF complex formation"}
{"concept_id": "C4232600", "aliases": [], "types": ["T043"], "canonical_name": "activation of beta-catenin-TCF complex assembly"}
{"concept_id": "C4232601", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of beta-catenin/T-cell factor complex formation"}
{"concept_id": "C4232602", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of beta-catenin/T-cell factor complex assembly"}
{"concept_id": "C4232603", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of beta-catenin/lymphoid enhancer binding factor complex formation"}
{"concept_id": "C4232604", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of beta-catenin/lymphoid enhancer binding factor complex assembly"}
{"concept_id": "C4232605", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of beta-catenin/LEF complex formation"}
{"concept_id": "C4232606", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of beta-catenin/LEF complex assembly"}
{"concept_id": "C4232607", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of beta-catenin/T-cell factor complex formation"}
{"concept_id": "C4232608", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of beta-catenin/T-cell factor complex assembly"}
{"concept_id": "C4232609", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of beta-catenin/lymphoid enhancer binding factor complex formation"}
{"concept_id": "C4232610", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of beta-catenin/lymphoid enhancer binding factor complex assembly"}
{"concept_id": "C4232611", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of beta-catenin/LEF complex formation"}
{"concept_id": "C4232612", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of beta-catenin/LEF complex assembly"}
{"concept_id": "C4232613", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of beta-catenin-TCF complex formation"}
{"concept_id": "C4232614", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of beta-catenin-TCF complex assembly"}
{"concept_id": "C4232615", "aliases": ["downregulation of beta-catenin/T-cell factor complex formation", "down-regulation of beta-catenin/T-cell factor complex formation"], "types": ["T043"], "canonical_name": "down regulation of beta-catenin/T-cell factor complex formation"}
{"concept_id": "C4232616", "aliases": ["downregulation of beta-catenin/T-cell factor complex assembly", "down-regulation of beta-catenin/T-cell factor complex assembly"], "types": ["T043"], "canonical_name": "down regulation of beta-catenin/T-cell factor complex assembly"}
{"concept_id": "C4232617", "aliases": ["down-regulation of beta-catenin/lymphoid enhancer binding factor complex formation", "downregulation of beta-catenin/lymphoid enhancer binding factor complex formation"], "types": ["T043"], "canonical_name": "down regulation of beta-catenin/lymphoid enhancer binding factor complex formation"}
{"concept_id": "C4232618", "aliases": ["down-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly", "downregulation of beta-catenin/lymphoid enhancer binding factor complex assembly"], "types": ["T043"], "canonical_name": "down regulation of beta-catenin/lymphoid enhancer binding factor complex assembly"}
{"concept_id": "C4232619", "aliases": ["down-regulation of beta-catenin/LEF complex formation", "downregulation of beta-catenin/LEF complex formation"], "types": ["T043"], "canonical_name": "down regulation of beta-catenin/LEF complex formation"}
{"concept_id": "C4232620", "aliases": ["down-regulation of beta-catenin/LEF complex assembly", "downregulation of beta-catenin/LEF complex assembly"], "types": ["T043"], "canonical_name": "down regulation of beta-catenin/LEF complex assembly"}
{"concept_id": "C4232621", "aliases": [], "types": ["T043"], "canonical_name": "regulation of beta-catenin/T-cell factor complex formation"}
{"concept_id": "C4232622", "aliases": [], "types": ["T043"], "canonical_name": "regulation of beta-catenin/T-cell factor complex assembly"}
{"concept_id": "C4232623", "aliases": [], "types": ["T043"], "canonical_name": "regulation of beta-catenin/lymphoid enhancer binding factor complex formation"}
{"concept_id": "C4232624", "aliases": [], "types": ["T043"], "canonical_name": "regulation of beta-catenin/lymphoid enhancer binding factor complex assembly"}
{"concept_id": "C4232625", "aliases": [], "types": ["T043"], "canonical_name": "regulation of beta-catenin/LEF complex formation"}
{"concept_id": "C4232626", "aliases": [], "types": ["T043"], "canonical_name": "regulation of beta-catenin/LEF complex assembly"}
{"concept_id": "C4232627", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle"}
{"concept_id": "C4232628", "aliases": [], "types": ["T044"], "canonical_name": "DNA synthesis involved in DNA replication during S phase involved in mitotic cell cycle"}
{"concept_id": "C4232629", "aliases": [], "types": ["T045"], "canonical_name": "DNA formation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle"}
{"concept_id": "C4232630", "aliases": [], "types": ["T044"], "canonical_name": "DNA formation involved in DNA replication during S phase involved in mitotic cell cycle"}
{"concept_id": "C4232631", "aliases": [], "types": ["T044"], "canonical_name": "DNA biosynthetic process involved in nuclear cell cycle DNA replication involved in mitotic cell cycle"}
{"concept_id": "C4232632", "aliases": [], "types": ["T044"], "canonical_name": "DNA biosynthetic process involved in DNA replication during S phase involved in mitotic cell cycle"}
{"concept_id": "C4232633", "aliases": [], "types": ["T044"], "canonical_name": "DNA biosynthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle"}
{"concept_id": "C4232634", "aliases": [], "types": ["T044"], "canonical_name": "DNA biosynthesis involved in DNA replication during S phase involved in mitotic cell cycle"}
{"concept_id": "C4232635", "aliases": [], "types": ["T044"], "canonical_name": "DNA anabolism involved in nuclear cell cycle DNA replication involved in mitotic cell cycle"}
{"concept_id": "C4232636", "aliases": [], "types": ["T044"], "canonical_name": "DNA anabolism involved in DNA replication during S phase involved in mitotic cell cycle"}
{"concept_id": "C4232637", "aliases": [], "types": ["T043"], "canonical_name": "activation of endothelial cell chemotaxis to vascular endothelial growth factor"}
{"concept_id": "C4232638", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelial cell chemotaxis to vascular endothelial growth factor"}
{"concept_id": "C4232639", "aliases": [], "types": ["T044"], "canonical_name": "PA700 proteasome activator binding"}
{"concept_id": "C4232640", "aliases": [], "types": ["T044"], "canonical_name": "modulator complex binding"}
{"concept_id": "C4232641", "aliases": [], "types": ["T044"], "canonical_name": "19S regulatory particle binding"}
{"concept_id": "C4232642", "aliases": [], "types": ["T044"], "canonical_name": "PA28gamma-20S proteasome binding"}
{"concept_id": "C4232643", "aliases": [], "types": ["T044"], "canonical_name": "20S proteasome binding"}
{"concept_id": "C4232644", "aliases": [], "types": ["T044"], "canonical_name": "20S core complex binding"}
{"concept_id": "C4232645", "aliases": ["activation of establishment of protein localization to telomere"], "types": ["T043"], "canonical_name": "activation of establishment of protein localisation to telomere"}
{"concept_id": "C4232646", "aliases": [], "types": ["T039"], "canonical_name": "activation of establishment of protein localization to chromosome, telomeric region"}
{"concept_id": "C4232647", "aliases": ["inhibition of establishment of protein localization to telomere"], "types": ["T043"], "canonical_name": "inhibition of establishment of protein localisation to telomere"}
{"concept_id": "C4232648", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of establishment of protein localization to chromosome, telomeric region"}
{"concept_id": "C4232649", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell chemotaxis to fibroblast growth factor"}
{"concept_id": "C4232650", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell chemotaxis to fibroblast growth factor"}
{"concept_id": "C4232651", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of establishment of bipolar cell polarity"}
{"concept_id": "C4232652", "aliases": [], "types": ["T044"], "canonical_name": "mTORC2 binding"}
{"concept_id": "C4232653", "aliases": [], "types": ["T043"], "canonical_name": "activation of male germ-line stem cell renewal"}
{"concept_id": "C4232654", "aliases": [], "types": ["T043"], "canonical_name": "activation of male germ-line stem cell asymmetric division"}
{"concept_id": "C4232655", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of male germ-line stem cell renewal"}
{"concept_id": "C4232656", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of male germ-line stem cell asymmetric division"}
{"concept_id": "C4232657", "aliases": [], "types": ["T044"], "canonical_name": "beta-catenin/T-cell factor complex formation"}
{"concept_id": "C4232658", "aliases": [], "types": ["T044"], "canonical_name": "beta-catenin/T-cell factor complex assembly"}
{"concept_id": "C4232659", "aliases": [], "types": ["T044"], "canonical_name": "beta-catenin/lymphoid enhancer binding factor complex formation"}
{"concept_id": "C4232660", "aliases": [], "types": ["T044"], "canonical_name": "beta-catenin/lymphoid enhancer binding factor complex assembly"}
{"concept_id": "C4232661", "aliases": [], "types": ["T044"], "canonical_name": "beta-catenin/LEF complex formation"}
{"concept_id": "C4232662", "aliases": [], "types": ["T044"], "canonical_name": "beta-catenin/LEF complex assembly"}
{"concept_id": "C4232663", "aliases": ["acoustico-facial VII-VIII ganglion complex morphogenesis", "facio-acoustic ganglion complex VII-VIII morphogenesis"], "types": ["T043"], "canonical_name": "facio-acoustic VII-VIII ganglion complex morphogenesis"}
{"concept_id": "C4232664", "aliases": [], "types": ["T042"], "canonical_name": "facio-acoustic ganglion complex morphogenesis"}
{"concept_id": "C4232665", "aliases": [], "types": ["T042"], "canonical_name": "posterior root ganglion morphogenesis"}
{"concept_id": "C4232666", "aliases": [], "types": ["T042"], "canonical_name": "ganglion spinale morphogenesis"}
{"concept_id": "C4232667", "aliases": [], "types": ["T042"], "canonical_name": "ganglion sensorium nervi spinalis morphogenesis"}
{"concept_id": "C4232668", "aliases": [], "types": ["T042"], "canonical_name": "DRG morphogenesis"}
{"concept_id": "C4232669", "aliases": ["ganglion spinalis morphogenesis", "spinal ganglion morphogenesis", "dorsal root ganglia morphogenesis", "spinal ganglion part of peripheral nervous system morphogenesis", "ganglion of dorsal root morphogenesis"], "types": ["T042"], "canonical_name": "dorsal root ganglion morphogenesis", "definition": "The developmental process by which a dorsal root ganglion is generated and organized. [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]"}
{"concept_id": "C4232671", "aliases": [], "types": ["T043"], "canonical_name": "activation of removal of superoxide radicals"}
{"concept_id": "C4232672", "aliases": [], "types": ["T043"], "canonical_name": "activation of removal of oxygen free radicals"}
{"concept_id": "C4232673", "aliases": [], "types": ["T043"], "canonical_name": "activation of removal of O2-"}
{"concept_id": "C4232674", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular detoxification of superoxide radicals"}
{"concept_id": "C4232675", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of removal of superoxide radicals"}
{"concept_id": "C4232676", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of removal of oxygen free radicals"}
{"concept_id": "C4232677", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of removal of O2-"}
{"concept_id": "C4232678", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular detoxification of superoxide radicals"}
{"concept_id": "C4232679", "aliases": [], "types": ["T043"], "canonical_name": "activation of aortic smooth muscle cell differentiation"}
{"concept_id": "C4232680", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of aortic smooth muscle cell differentiation"}
{"concept_id": "C4232681", "aliases": ["activation of hydrogen sulphide biosynthetic process"], "types": ["T044"], "canonical_name": "activation of hydrogen sulfide biosynthetic process"}
{"concept_id": "C4232682", "aliases": ["activation of hydrogen sulphide biosynthesis"], "types": ["T044"], "canonical_name": "activation of hydrogen sulfide biosynthesis"}
{"concept_id": "C4232683", "aliases": [], "types": ["T044"], "canonical_name": "activation of hydrogen sulfide synthesis"}
{"concept_id": "C4232684", "aliases": [], "types": ["T044"], "canonical_name": "activation of hydrogen sulfide formation"}
{"concept_id": "C4232685", "aliases": [], "types": ["T044"], "canonical_name": "activation of hydrogen sulfide anabolism"}
{"concept_id": "C4232686", "aliases": ["inhibition of hydrogen sulphide biosynthetic process"], "types": ["T044"], "canonical_name": "inhibition of hydrogen sulfide biosynthetic process"}
{"concept_id": "C4232687", "aliases": ["inhibition of hydrogen sulphide biosynthesis"], "types": ["T044"], "canonical_name": "inhibition of hydrogen sulfide biosynthesis"}
{"concept_id": "C4232688", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hydrogen sulfide synthesis"}
{"concept_id": "C4232689", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hydrogen sulfide formation"}
{"concept_id": "C4232690", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hydrogen sulfide anabolism"}
{"concept_id": "C4232691", "aliases": ["APC assembly", "anaphase-promoting complex formation", "anaphase promoting complex assembly", "cyclosome assembly", "cyclosome formation", "anaphase promoting complex formation"], "types": ["T043"], "canonical_name": "anaphase-promoting complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an anaphase-promoting complex. [GO_REF:0000079, GOC:TermGenie, PMID:16950791]"}
{"concept_id": "C4232697", "aliases": [], "types": ["T043"], "canonical_name": "chloroplast degradation"}
{"concept_id": "C4232698", "aliases": ["peritonaeum development"], "types": ["T042"], "canonical_name": "peritoneum development", "definition": "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]"}
{"concept_id": "C4232699", "aliases": [], "types": ["T042"], "canonical_name": "serosa development"}
{"concept_id": "C4232700", "aliases": [], "types": ["T045"], "canonical_name": "activation of protein localization to telomere"}
{"concept_id": "C4232701", "aliases": ["activation of protein localization to chromosome, telomeric region"], "types": ["T045"], "canonical_name": "activation of protein localisation to chromosome, telomeric region"}
{"concept_id": "C4232702", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of protein localization to telomere"}
{"concept_id": "C4232703", "aliases": ["inhibition of protein localization to chromosome, telomeric region"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to chromosome, telomeric region"}
{"concept_id": "C4232704", "aliases": [], "types": ["T026"], "canonical_name": "membrane-enclosed lumen of ficolin granule"}
{"concept_id": "C4232705", "aliases": [], "types": ["T045"], "canonical_name": "rRNA acetylation involved in processing of 20S pre-rRNA"}
{"concept_id": "C4232706", "aliases": [], "types": ["T043"], "canonical_name": "activation of dense core vesicle transport"}
{"concept_id": "C4232707", "aliases": [], "types": ["T043"], "canonical_name": "activation of dense core granule transport"}
{"concept_id": "C4232708", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dense core vesicle transport"}
{"concept_id": "C4232709", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dense core granule transport"}
{"concept_id": "C4232710", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein oxidation"}
{"concept_id": "C4232711", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein amino acid oxidation"}
{"concept_id": "C4232712", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein oxidation"}
{"concept_id": "C4232713", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein amino acid oxidation"}
{"concept_id": "C4232714", "aliases": ["up-regulation of axon pruning", "upregulation of axon pruning"], "types": ["T043"], "canonical_name": "up regulation of axon pruning"}
{"concept_id": "C4232715", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of axon pruning"}
{"concept_id": "C4232716", "aliases": [], "types": ["T042"], "canonical_name": "activation of neuronal remodeling"}
{"concept_id": "C4232717", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuron remodeling"}
{"concept_id": "C4232718", "aliases": [], "types": ["T043"], "canonical_name": "activation of axon pruning"}
{"concept_id": "C4232719", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of axon pruning"}
{"concept_id": "C4232720", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of neuronal remodeling"}
{"concept_id": "C4232721", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuron remodeling"}
{"concept_id": "C4232722", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of axon pruning"}
{"concept_id": "C4232723", "aliases": ["downregulation of axon pruning", "down-regulation of axon pruning"], "types": ["T043"], "canonical_name": "down regulation of axon pruning"}
{"concept_id": "C4232724", "aliases": [], "types": ["T043"], "canonical_name": "regulation of axon pruning"}
{"concept_id": "C4232725", "aliases": [], "types": ["T045"], "canonical_name": "activation of core promoter binding"}
{"concept_id": "C4232726", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of core promoter binding"}
{"concept_id": "C4232727", "aliases": [], "types": ["T044"], "canonical_name": "activation of euchromatin binding"}
{"concept_id": "C4232728", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of euchromatin binding"}
{"concept_id": "C4232729", "aliases": [], "types": ["T043"], "canonical_name": "activation of telosome assembly"}
{"concept_id": "C4232730", "aliases": [], "types": ["T043"], "canonical_name": "activation of shelterin complex formation"}
{"concept_id": "C4232731", "aliases": [], "types": ["T043"], "canonical_name": "activation of Pot1-Tpz1 complex assembly"}
{"concept_id": "C4232732", "aliases": [], "types": ["T043"], "canonical_name": "activation of Pot1 complex assembly"}
{"concept_id": "C4232733", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of telosome assembly"}
{"concept_id": "C4232734", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of shelterin complex formation"}
{"concept_id": "C4232735", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Pot1-Tpz1 complex assembly"}
{"concept_id": "C4232736", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Pot1 complex assembly"}
{"concept_id": "C4232740", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell fate commitment, asymmetric protein localization"}
{"concept_id": "C4232741", "aliases": [], "types": ["T043"], "canonical_name": "activation of asymmetric protein localization resulting in cell fate commitment"}
{"concept_id": "C4232742", "aliases": ["activation of asymmetric protein localization involved in cell fate determination"], "types": ["T043"], "canonical_name": "activation of asymmetric protein localisation involved in cell fate determination"}
{"concept_id": "C4232743", "aliases": [], "types": ["T043"], "canonical_name": "activation of asymmetric protein localization involved in cell fate commitment"}
{"concept_id": "C4232744", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell fate commitment, asymmetric protein localization"}
{"concept_id": "C4232745", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of asymmetric protein localization resulting in cell fate commitment"}
{"concept_id": "C4232746", "aliases": ["inhibition of asymmetric protein localization involved in cell fate determination"], "types": ["T043"], "canonical_name": "inhibition of asymmetric protein localisation involved in cell fate determination"}
{"concept_id": "C4232747", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of asymmetric protein localization involved in cell fate commitment"}
{"concept_id": "C4232748", "aliases": [], "types": ["T043"], "canonical_name": "activation of NMDA receptor"}
{"concept_id": "C4232749", "aliases": [], "types": ["T043"], "canonical_name": "activation of NMDA glutamate receptor activity"}
{"concept_id": "C4232750", "aliases": [], "types": ["T043"], "canonical_name": "activation of N-methyl-D-aspartate selective glutamate receptor activity"}
{"concept_id": "C4232751", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of NMDA receptor"}
{"concept_id": "C4232752", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of NMDA glutamate receptor activity"}
{"concept_id": "C4232753", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of N-methyl-D-aspartate selective glutamate receptor activity"}
{"concept_id": "C4232754", "aliases": ["activation of protein localization to centrosome"], "types": ["T043"], "canonical_name": "activation of protein localisation to centrosome"}
{"concept_id": "C4232755", "aliases": ["inhibition of protein localization to centrosome"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to centrosome"}
{"concept_id": "C4232756", "aliases": ["activation of protein localization to cell cortex"], "types": ["T043"], "canonical_name": "activation of protein localisation to cell cortex"}
{"concept_id": "C4232757", "aliases": ["inhibition of protein localization to cell cortex"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to cell cortex"}
{"concept_id": "C4232758", "aliases": ["up-regulation of coenzyme Q9 biosynthetic process", "upregulation of coenzyme Q9 biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of coenzyme Q9 biosynthetic process"}
{"concept_id": "C4232759", "aliases": ["up-regulation of coenzyme Q9 biosynthesis", "upregulation of coenzyme Q9 biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of coenzyme Q9 biosynthesis"}
{"concept_id": "C4232760", "aliases": ["up-regulation of coenzyme Q8 biosynthetic process", "upregulation of coenzyme Q8 biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of coenzyme Q8 biosynthetic process"}
{"concept_id": "C4232761", "aliases": ["upregulation of coenzyme Q8 biosynthesis", "up-regulation of coenzyme Q8 biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of coenzyme Q8 biosynthesis"}
{"concept_id": "C4232762", "aliases": ["up-regulation of coenzyme Q6 biosynthetic process", "upregulation of coenzyme Q6 biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of coenzyme Q6 biosynthetic process"}
{"concept_id": "C4232763", "aliases": ["up-regulation of coenzyme Q6 biosynthesis", "upregulation of coenzyme Q6 biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of coenzyme Q6 biosynthesis"}
{"concept_id": "C4232764", "aliases": ["up-regulation of coenzyme Q10 biosynthetic process", "upregulation of coenzyme Q10 biosynthetic process"], "types": ["T044"], "canonical_name": "up regulation of coenzyme Q10 biosynthetic process"}
{"concept_id": "C4232765", "aliases": ["up-regulation of coenzyme Q10 biosynthesis", "upregulation of coenzyme Q10 biosynthesis"], "types": ["T044"], "canonical_name": "up regulation of coenzyme Q10 biosynthesis"}
{"concept_id": "C4232766", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of coenzyme Q9 biosynthetic process"}
{"concept_id": "C4232767", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of coenzyme Q9 biosynthesis"}
{"concept_id": "C4232768", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of coenzyme Q8 biosynthetic process"}
{"concept_id": "C4232769", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of coenzyme Q8 biosynthesis"}
{"concept_id": "C4232770", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of coenzyme Q6 biosynthetic process"}
{"concept_id": "C4232771", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of coenzyme Q6 biosynthesis"}
{"concept_id": "C4232772", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of coenzyme Q10 biosynthetic process"}
{"concept_id": "C4232773", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of coenzyme Q10 biosynthesis"}
{"concept_id": "C4232774", "aliases": [], "types": ["T044"], "canonical_name": "activation of ubiquinone synthesis"}
{"concept_id": "C4232775", "aliases": [], "types": ["T044"], "canonical_name": "activation of ubiquinone formation"}
{"concept_id": "C4232776", "aliases": [], "types": ["T044"], "canonical_name": "activation of ubiquinone biosynthetic process"}
{"concept_id": "C4232777", "aliases": [], "types": ["T044"], "canonical_name": "activation of ubiquinone biosynthesis"}
{"concept_id": "C4232778", "aliases": [], "types": ["T044"], "canonical_name": "activation of ubiquinone anabolism"}
{"concept_id": "C4232779", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q9 biosynthetic process"}
{"concept_id": "C4232780", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q9 biosynthesis"}
{"concept_id": "C4232781", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q8 biosynthetic process"}
{"concept_id": "C4232782", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q8 biosynthesis"}
{"concept_id": "C4232783", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q6 biosynthetic process"}
{"concept_id": "C4232784", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q6 biosynthesis"}
{"concept_id": "C4232785", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q10 biosynthetic process"}
{"concept_id": "C4232786", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q10 biosynthesis"}
{"concept_id": "C4232787", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q biosynthetic process"}
{"concept_id": "C4232788", "aliases": [], "types": ["T044"], "canonical_name": "activation of coenzyme Q biosynthesis"}
{"concept_id": "C4232789", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of coenzyme Q9 biosynthetic process"}
{"concept_id": "C4232790", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of coenzyme Q9 biosynthesis"}
{"concept_id": "C4232791", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of coenzyme Q8 biosynthetic process"}
{"concept_id": "C4232792", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of coenzyme Q8 biosynthesis"}
{"concept_id": "C4232793", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of coenzyme Q6 biosynthetic process"}
{"concept_id": "C4232794", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of coenzyme Q6 biosynthesis"}
{"concept_id": "C4232795", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of coenzyme Q10 biosynthetic process"}
{"concept_id": "C4232796", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of coenzyme Q10 biosynthesis"}
{"concept_id": "C4232797", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ubiquinone synthesis"}
{"concept_id": "C4232798", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ubiquinone formation"}
{"concept_id": "C4232799", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ubiquinone biosynthetic process"}
{"concept_id": "C4232800", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ubiquinone biosynthesis"}
{"concept_id": "C4232801", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ubiquinone anabolism"}
{"concept_id": "C4232802", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q9 biosynthetic process"}
{"concept_id": "C4232803", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q9 biosynthesis"}
{"concept_id": "C4232804", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q8 biosynthetic process"}
{"concept_id": "C4232805", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q8 biosynthesis"}
{"concept_id": "C4232806", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q6 biosynthetic process"}
{"concept_id": "C4232807", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q6 biosynthesis"}
{"concept_id": "C4232808", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q10 biosynthetic process"}
{"concept_id": "C4232809", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q10 biosynthesis"}
{"concept_id": "C4232810", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q biosynthetic process"}
{"concept_id": "C4232811", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of coenzyme Q biosynthesis"}
{"concept_id": "C4232812", "aliases": ["down-regulation of coenzyme Q9 biosynthetic process", "downregulation of coenzyme Q9 biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of coenzyme Q9 biosynthetic process"}
{"concept_id": "C4232813", "aliases": ["down-regulation of coenzyme Q9 biosynthesis", "downregulation of coenzyme Q9 biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of coenzyme Q9 biosynthesis"}
{"concept_id": "C4232814", "aliases": ["down-regulation of coenzyme Q8 biosynthetic process", "downregulation of coenzyme Q8 biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of coenzyme Q8 biosynthetic process"}
{"concept_id": "C4232815", "aliases": ["downregulation of coenzyme Q8 biosynthesis", "down-regulation of coenzyme Q8 biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of coenzyme Q8 biosynthesis"}
{"concept_id": "C4232816", "aliases": ["down-regulation of coenzyme Q6 biosynthetic process", "downregulation of coenzyme Q6 biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of coenzyme Q6 biosynthetic process"}
{"concept_id": "C4232817", "aliases": ["downregulation of coenzyme Q6 biosynthesis", "down-regulation of coenzyme Q6 biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of coenzyme Q6 biosynthesis"}
{"concept_id": "C4232818", "aliases": ["downregulation of coenzyme Q10 biosynthetic process", "down-regulation of coenzyme Q10 biosynthetic process"], "types": ["T044"], "canonical_name": "down regulation of coenzyme Q10 biosynthetic process"}
{"concept_id": "C4232819", "aliases": ["downregulation of coenzyme Q10 biosynthesis", "down-regulation of coenzyme Q10 biosynthesis"], "types": ["T044"], "canonical_name": "down regulation of coenzyme Q10 biosynthesis"}
{"concept_id": "C4232820", "aliases": ["membrane bone morphogenesis"], "types": ["T042"], "canonical_name": "membrane bone morphogenesis", "definition": "The process in which bone which forms deep in the organism are generated and organized. [PMID:14579374]"}
{"concept_id": "C4232822", "aliases": ["up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus", "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus"], "types": ["T045"], "canonical_name": "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus"}
{"concept_id": "C4232823", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus"}
{"concept_id": "C4232824", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter, global involved in cellular response to maltose stimulus"}
{"concept_id": "C4232825", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of global transcription from Pol II promoter involved in cellular response to maltose stimulus"}
{"concept_id": "C4232826", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus"}
{"concept_id": "C4232827", "aliases": [], "types": ["T045"], "canonical_name": "activation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus"}
{"concept_id": "C4232828", "aliases": [], "types": ["T043"], "canonical_name": "CMA receptor complex disassembly"}
{"concept_id": "C4232829", "aliases": [], "types": ["T044"], "canonical_name": "chaperone-mediated autophagy receptor complex disassembly"}
{"concept_id": "C4232830", "aliases": [], "types": ["T043"], "canonical_name": "CMA receptor complex formation"}
{"concept_id": "C4232831", "aliases": [], "types": ["T043"], "canonical_name": "CMA receptor complex assembly"}
{"concept_id": "C4232832", "aliases": [], "types": ["T043"], "canonical_name": "chaperone-mediated autophagy receptor complex formation"}
{"concept_id": "C4232833", "aliases": [], "types": ["T044"], "canonical_name": "chaperone-mediated autophagy receptor complex assembly"}
{"concept_id": "C4232834", "aliases": [], "types": ["T043"], "canonical_name": "activation of myofibroblast differentiation"}
{"concept_id": "C4232835", "aliases": [], "types": ["T043"], "canonical_name": "activation of myofibroblast cell differentiation"}
{"concept_id": "C4232836", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myofibroblast differentiation"}
{"concept_id": "C4232837", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myofibroblast cell differentiation"}
{"concept_id": "C4232838", "aliases": [], "types": ["T043"], "canonical_name": "activation of gut granule formation"}
{"concept_id": "C4232839", "aliases": [], "types": ["T043"], "canonical_name": "activation of gut granule biogenesis"}
{"concept_id": "C4232840", "aliases": [], "types": ["T043"], "canonical_name": "activation of gut granule assembly"}
{"concept_id": "C4232841", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gut granule formation"}
{"concept_id": "C4232842", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gut granule biogenesis"}
{"concept_id": "C4232843", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gut granule assembly"}
{"concept_id": "C4232844", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular smooth muscle cell migration"}
{"concept_id": "C4232845", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular associated smooth muscle cell migration"}
{"concept_id": "C4232846", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vascular smooth muscle cell migration"}
{"concept_id": "C4232847", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vascular associated smooth muscle cell migration"}
{"concept_id": "C4232848", "aliases": ["activation of protein localization to nucleolus"], "types": ["T043"], "canonical_name": "activation of protein localisation to nucleolus"}
{"concept_id": "C4232849", "aliases": ["activation of protein localization in nucleolus"], "types": ["T043"], "canonical_name": "activation of protein localisation in nucleolus"}
{"concept_id": "C4232850", "aliases": ["inhibition of protein localization to nucleolus"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to nucleolus"}
{"concept_id": "C4232851", "aliases": ["inhibition of protein localization in nucleolus"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in nucleolus"}
{"concept_id": "C4232852", "aliases": [], "types": ["T043"], "canonical_name": "regulation of type I programmed cell death involved in development of an anatomical structure"}
{"concept_id": "C4232853", "aliases": [], "types": ["T043"], "canonical_name": "regulation of type I programmed cell death involved in anatomical structure development"}
{"concept_id": "C4232854", "aliases": [], "types": ["T043"], "canonical_name": "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure"}
{"concept_id": "C4232855", "aliases": [], "types": ["T043"], "canonical_name": "regulation of signaling (initiator) caspase activity involved in anatomical structure development"}
{"concept_id": "C4232856", "aliases": [], "types": ["T043"], "canonical_name": "regulation of induction of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232857", "aliases": [], "types": ["T043"], "canonical_name": "regulation of induction of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232858", "aliases": [], "types": ["T043"], "canonical_name": "regulation of induction of apoptosis by p53 involved in development of an anatomical structure"}
{"concept_id": "C4232859", "aliases": [], "types": ["T043"], "canonical_name": "regulation of induction of apoptosis by p53 involved in anatomical structure development"}
{"concept_id": "C4232860", "aliases": [], "types": ["T043"], "canonical_name": "regulation of commitment to apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232861", "aliases": [], "types": ["T043"], "canonical_name": "regulation of commitment to apoptosis involved in anatomical structure development"}
{"concept_id": "C4232862", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptotic program involved in development of an anatomical structure"}
{"concept_id": "C4232863", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptotic program involved in anatomical structure development"}
{"concept_id": "C4232864", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptosis signaling involved in development of an anatomical structure"}
{"concept_id": "C4232865", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptosis signaling involved in anatomical structure development"}
{"concept_id": "C4232866", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232867", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232868", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptosis activator activity involved in development of an anatomical structure"}
{"concept_id": "C4232869", "aliases": [], "types": ["T043"], "canonical_name": "regulation of apoptosis activator activity involved in anatomical structure development"}
{"concept_id": "C4232870", "aliases": [], "types": ["T043"], "canonical_name": "regulation of activation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232871", "aliases": [], "types": ["T043"], "canonical_name": "regulation of activation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232872", "aliases": ["upregulation of type I programmed cell death involved in development of an anatomical structure", "up-regulation of type I programmed cell death involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of type I programmed cell death involved in development of an anatomical structure"}
{"concept_id": "C4232873", "aliases": ["upregulation of type I programmed cell death involved in anatomical structure development", "up-regulation of type I programmed cell death involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of type I programmed cell death involved in anatomical structure development"}
{"concept_id": "C4232874", "aliases": ["upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure", "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure"}
{"concept_id": "C4232875", "aliases": ["upregulation of signaling (initiator) caspase activity involved in anatomical structure development", "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of signaling (initiator) caspase activity involved in anatomical structure development"}
{"concept_id": "C4232876", "aliases": ["upregulation of induction of apoptosis involved in development of an anatomical structure", "up-regulation of induction of apoptosis involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of induction of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232877", "aliases": ["upregulation of induction of apoptosis involved in anatomical structure development", "up-regulation of induction of apoptosis involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of induction of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232878", "aliases": ["up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure", "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure"}
{"concept_id": "C4232879", "aliases": ["upregulation of induction of apoptosis by p53 involved in anatomical structure development", "up-regulation of induction of apoptosis by p53 involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of induction of apoptosis by p53 involved in anatomical structure development"}
{"concept_id": "C4232880", "aliases": ["up-regulation of commitment to apoptosis involved in development of an anatomical structure", "upregulation of commitment to apoptosis involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of commitment to apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232881", "aliases": ["upregulation of commitment to apoptosis involved in anatomical structure development", "up-regulation of commitment to apoptosis involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of commitment to apoptosis involved in anatomical structure development"}
{"concept_id": "C4232882", "aliases": ["upregulation of apoptotic program involved in development of an anatomical structure", "up-regulation of apoptotic program involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of apoptotic program involved in development of an anatomical structure"}
{"concept_id": "C4232883", "aliases": ["upregulation of apoptotic program involved in anatomical structure development", "up-regulation of apoptotic program involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of apoptotic program involved in anatomical structure development"}
{"concept_id": "C4232884", "aliases": ["upregulation of apoptosis signaling involved in development of an anatomical structure", "up-regulation of apoptosis signaling involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of apoptosis signaling involved in development of an anatomical structure"}
{"concept_id": "C4232885", "aliases": ["upregulation of apoptosis signaling involved in anatomical structure development", "up-regulation of apoptosis signaling involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of apoptosis signaling involved in anatomical structure development"}
{"concept_id": "C4232886", "aliases": ["upregulation of apoptosis involved in development of an anatomical structure", "up-regulation of apoptosis involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232887", "aliases": ["up-regulation of apoptosis involved in anatomical structure development", "upregulation of apoptosis involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232888", "aliases": ["upregulation of apoptosis activator activity involved in development of an anatomical structure", "up-regulation of apoptosis activator activity involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of apoptosis activator activity involved in development of an anatomical structure"}
{"concept_id": "C4232889", "aliases": ["upregulation of apoptosis activator activity involved in anatomical structure development", "up-regulation of apoptosis activator activity involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of apoptosis activator activity involved in anatomical structure development"}
{"concept_id": "C4232890", "aliases": ["up-regulation of activation of apoptosis involved in development of an anatomical structure", "upregulation of activation of apoptosis involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "up regulation of activation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232891", "aliases": ["upregulation of activation of apoptosis involved in anatomical structure development", "up-regulation of activation of apoptosis involved in anatomical structure development"], "types": ["T043"], "canonical_name": "up regulation of activation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232892", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of type I programmed cell death involved in development of an anatomical structure"}
{"concept_id": "C4232893", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of type I programmed cell death involved in anatomical structure development"}
{"concept_id": "C4232894", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure"}
{"concept_id": "C4232895", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development"}
{"concept_id": "C4232896", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of induction of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232897", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of induction of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232898", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure"}
{"concept_id": "C4232899", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of induction of apoptosis by p53 involved in anatomical structure development"}
{"concept_id": "C4232900", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of commitment to apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232901", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of commitment to apoptosis involved in anatomical structure development"}
{"concept_id": "C4232902", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptotic program involved in development of an anatomical structure"}
{"concept_id": "C4232903", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptotic program involved in anatomical structure development"}
{"concept_id": "C4232904", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptosis signaling involved in development of an anatomical structure"}
{"concept_id": "C4232905", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptosis signaling involved in anatomical structure development"}
{"concept_id": "C4232906", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232907", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232908", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptosis activator activity involved in development of an anatomical structure"}
{"concept_id": "C4232909", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptosis activator activity involved in anatomical structure development"}
{"concept_id": "C4232910", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of activation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232911", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of activation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232912", "aliases": [], "types": ["T043"], "canonical_name": "activation of type I programmed cell death involved in development of an anatomical structure"}
{"concept_id": "C4232913", "aliases": [], "types": ["T043"], "canonical_name": "activation of type I programmed cell death involved in anatomical structure development"}
{"concept_id": "C4232914", "aliases": [], "types": ["T043"], "canonical_name": "activation of signaling (initiator) caspase activity involved in development of an anatomical structure"}
{"concept_id": "C4232915", "aliases": [], "types": ["T043"], "canonical_name": "activation of signaling (initiator) caspase activity involved in anatomical structure development"}
{"concept_id": "C4232916", "aliases": [], "types": ["T043"], "canonical_name": "activation of programmed cell death by apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232917", "aliases": [], "types": ["T043"], "canonical_name": "activation of programmed cell death by apoptosis involved in anatomical structure development"}
{"concept_id": "C4232918", "aliases": [], "types": ["T043"], "canonical_name": "activation of induction of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232919", "aliases": [], "types": ["T043"], "canonical_name": "activation of induction of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232920", "aliases": [], "types": ["T043"], "canonical_name": "activation of induction of apoptosis by p53 involved in development of an anatomical structure"}
{"concept_id": "C4232921", "aliases": [], "types": ["T043"], "canonical_name": "activation of induction of apoptosis by p53 involved in anatomical structure development"}
{"concept_id": "C4232922", "aliases": [], "types": ["T043"], "canonical_name": "activation of commitment to apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232923", "aliases": [], "types": ["T043"], "canonical_name": "activation of commitment to apoptosis involved in anatomical structure development"}
{"concept_id": "C4232924", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic programmed cell death involved in development of an anatomical structure"}
{"concept_id": "C4232925", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic programmed cell death involved in anatomical structure development"}
{"concept_id": "C4232926", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic program involved in development of an anatomical structure"}
{"concept_id": "C4232927", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic program involved in anatomical structure development"}
{"concept_id": "C4232928", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic process involved in development of an anatomical structure"}
{"concept_id": "C4232929", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic process involved in development"}
{"concept_id": "C4232930", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic process involved in anatomical structure development"}
{"concept_id": "C4232931", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic cell death involved in development of an anatomical structure"}
{"concept_id": "C4232932", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptotic cell death involved in anatomical structure development"}
{"concept_id": "C4232933", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptosis signaling involved in development of an anatomical structure"}
{"concept_id": "C4232934", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptosis signaling involved in anatomical structure development"}
{"concept_id": "C4232935", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptosis activator activity involved in development of an anatomical structure"}
{"concept_id": "C4232936", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptosis activator activity involved in anatomical structure development"}
{"concept_id": "C4232937", "aliases": [], "types": ["T043"], "canonical_name": "activation of activation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232938", "aliases": [], "types": ["T043"], "canonical_name": "activation of activation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232939", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of type I programmed cell death involved in development of an anatomical structure"}
{"concept_id": "C4232940", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of type I programmed cell death involved in anatomical structure development"}
{"concept_id": "C4232941", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure"}
{"concept_id": "C4232942", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development"}
{"concept_id": "C4232943", "aliases": ["negative regulation of induction of apoptosis involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "negative regulation of induction of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232944", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure"}
{"concept_id": "C4232945", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of induction of apoptosis by p53 involved in anatomical structure development"}
{"concept_id": "C4232946", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of commitment to apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232947", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of commitment to apoptosis involved in anatomical structure development"}
{"concept_id": "C4232948", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptotic program involved in development of an anatomical structure"}
{"concept_id": "C4232949", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptotic program involved in anatomical structure development"}
{"concept_id": "C4232950", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptosis signaling involved in development of an anatomical structure"}
{"concept_id": "C4232951", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptosis signaling involved in anatomical structure development"}
{"concept_id": "C4232952", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232953", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232954", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptosis activator activity involved in development of an anatomical structure"}
{"concept_id": "C4232955", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of apoptosis activator activity involved in anatomical structure development"}
{"concept_id": "C4232956", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of activation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232957", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of activation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232958", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of type I programmed cell death involved in development of an anatomical structure"}
{"concept_id": "C4232959", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of type I programmed cell death involved in anatomical structure development"}
{"concept_id": "C4232960", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure"}
{"concept_id": "C4232961", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of signaling (initiator) caspase activity involved in anatomical structure development"}
{"concept_id": "C4232962", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232963", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of programmed cell death by apoptosis involved in anatomical structure development"}
{"concept_id": "C4232964", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of induction of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232965", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of induction of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232966", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure"}
{"concept_id": "C4232967", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of induction of apoptosis by p53 involved in anatomical structure development"}
{"concept_id": "C4232968", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of commitment to apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232969", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of commitment to apoptosis involved in anatomical structure development"}
{"concept_id": "C4232970", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic programmed cell death involved in development of an anatomical structure"}
{"concept_id": "C4232971", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic programmed cell death involved in anatomical structure development"}
{"concept_id": "C4232972", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic program involved in development of an anatomical structure"}
{"concept_id": "C4232973", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic program involved in anatomical structure development"}
{"concept_id": "C4232974", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic process involved in development of an anatomical structure"}
{"concept_id": "C4232975", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic process involved in development"}
{"concept_id": "C4232976", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic process involved in anatomical structure development"}
{"concept_id": "C4232977", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic cell death involved in development of an anatomical structure"}
{"concept_id": "C4232978", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptotic cell death involved in anatomical structure development"}
{"concept_id": "C4232979", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis signaling involved in development of an anatomical structure"}
{"concept_id": "C4232980", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis signaling involved in anatomical structure development"}
{"concept_id": "C4232981", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232982", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232983", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis activator activity involved in development of an anatomical structure"}
{"concept_id": "C4232984", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of apoptosis activator activity involved in anatomical structure development"}
{"concept_id": "C4232985", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of activation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232986", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of activation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232987", "aliases": ["down-regulation of type I programmed cell death involved in anatomical structure development", "down regulation of type I programmed cell death involved in development of an anatomical structure", "downregulation of type I programmed cell death involved in development of an anatomical structure", "downregulation of type I programmed cell death involved in anatomical structure development", "down-regulation of type I programmed cell death involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "down regulation of type I programmed cell death involved in anatomical structure development"}
{"concept_id": "C4232988", "aliases": ["downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure", "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure"}
{"concept_id": "C4232989", "aliases": ["down-regulation of signaling (initiator) caspase activity involved in anatomical structure development", "downregulation of signaling (initiator) caspase activity involved in anatomical structure development"], "types": ["T043"], "canonical_name": "down regulation of signaling (initiator) caspase activity involved in anatomical structure development"}
{"concept_id": "C4232990", "aliases": ["downregulation of induction of apoptosis involved in development of an anatomical structure", "down regulation of induction of apoptosis involved in development of an anatomical structure", "down-regulation of induction of apoptosis involved in anatomical structure development", "down-regulation of induction of apoptosis involved in development of an anatomical structure", "downregulation of induction of apoptosis involved in anatomical structure development"], "types": ["T043"], "canonical_name": "down regulation of induction of apoptosis involved in anatomical structure development"}
{"concept_id": "C4232991", "aliases": ["downregulation of induction of apoptosis by p53 involved in development of an anatomical structure", "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure"}
{"concept_id": "C4232992", "aliases": ["down-regulation of induction of apoptosis by p53 involved in anatomical structure development", "downregulation of induction of apoptosis by p53 involved in anatomical structure development"], "types": ["T043"], "canonical_name": "down regulation of induction of apoptosis by p53 involved in anatomical structure development"}
{"concept_id": "C4232993", "aliases": ["downregulation of commitment to apoptosis involved in development of an anatomical structure", "down-regulation of commitment to apoptosis involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "down regulation of commitment to apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4232994", "aliases": ["downregulation of commitment to apoptosis involved in anatomical structure development", "down-regulation of commitment to apoptosis involved in anatomical structure development"], "types": ["T043"], "canonical_name": "down regulation of commitment to apoptosis involved in anatomical structure development"}
{"concept_id": "C4232995", "aliases": ["downregulation of apoptotic program involved in development of an anatomical structure", "down-regulation of apoptotic program involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "down regulation of apoptotic program involved in development of an anatomical structure"}
{"concept_id": "C4232996", "aliases": ["down-regulation of apoptotic program involved in anatomical structure development", "downregulation of apoptotic program involved in anatomical structure development"], "types": ["T043"], "canonical_name": "down regulation of apoptotic program involved in anatomical structure development"}
{"concept_id": "C4232997", "aliases": ["downregulation of apoptosis signaling involved in development of an anatomical structure", "down-regulation of apoptosis signaling involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "down regulation of apoptosis signaling involved in development of an anatomical structure"}
{"concept_id": "C4232998", "aliases": ["downregulation of apoptosis signaling involved in anatomical structure development", "down-regulation of apoptosis signaling involved in anatomical structure development"], "types": ["T043"], "canonical_name": "down regulation of apoptosis signaling involved in anatomical structure development"}
{"concept_id": "C4232999", "aliases": ["down-regulation of apoptosis involved in development of an anatomical structure", "downregulation of apoptosis involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "down regulation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4233000", "aliases": ["down-regulation of apoptosis involved in anatomical structure development", "downregulation of apoptosis involved in anatomical structure development"], "types": ["T043"], "canonical_name": "down regulation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4233001", "aliases": ["down-regulation of apoptosis activator activity involved in development of an anatomical structure", "downregulation of apoptosis activator activity involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "down regulation of apoptosis activator activity involved in development of an anatomical structure"}
{"concept_id": "C4233002", "aliases": ["downregulation of apoptosis activator activity involved in anatomical structure development", "down-regulation of apoptosis activator activity involved in anatomical structure development"], "types": ["T043"], "canonical_name": "down regulation of apoptosis activator activity involved in anatomical structure development"}
{"concept_id": "C4233003", "aliases": ["downregulation of activation of apoptosis involved in development of an anatomical structure", "down-regulation of activation of apoptosis involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "down regulation of activation of apoptosis involved in development of an anatomical structure"}
{"concept_id": "C4233004", "aliases": ["downregulation of activation of apoptosis involved in anatomical structure development", "down-regulation of activation of apoptosis involved in anatomical structure development"], "types": ["T043"], "canonical_name": "down regulation of activation of apoptosis involved in anatomical structure development"}
{"concept_id": "C4233005", "aliases": [], "types": ["T044"], "canonical_name": "activation of telomeric repeat binding"}
{"concept_id": "C4233006", "aliases": [], "types": ["T044"], "canonical_name": "activation of telomeric DNA binding"}
{"concept_id": "C4233007", "aliases": [], "types": ["T044"], "canonical_name": "activation of telomere binding"}
{"concept_id": "C4233008", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomeric repeat binding"}
{"concept_id": "C4233009", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomeric DNA binding"}
{"concept_id": "C4233010", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomere binding"}
{"concept_id": "C4233023", "aliases": [], "types": ["T044"], "canonical_name": "activation of fatty acid beta-oxidation using acyl-CoA dehydrogenase"}
{"concept_id": "C4233024", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fatty acid beta-oxidation using acyl-CoA dehydrogenase"}
{"concept_id": "C4233025", "aliases": ["upregulation of thioredoxin-like 2Fe-2S ferredoxin", "up-regulation of thioredoxin-like 2Fe-2S ferredoxin"], "types": ["T044"], "canonical_name": "up regulation of thioredoxin-like 2Fe-2S ferredoxin"}
{"concept_id": "C4233026", "aliases": ["up-regulation of small blue copper electron carrier", "upregulation of small blue copper electron carrier"], "types": ["T044"], "canonical_name": "up regulation of small blue copper electron carrier"}
{"concept_id": "C4233027", "aliases": ["up-regulation of rubredoxin", "upregulation of rubredoxin"], "types": ["T044"], "canonical_name": "up regulation of rubredoxin"}
{"concept_id": "C4233028", "aliases": ["upregulation of redox-active disulfide bond electron carrier", "up-regulation of redox-active disulfide bond electron carrier"], "types": ["T044"], "canonical_name": "up regulation of redox-active disulfide bond electron carrier"}
{"concept_id": "C4233029", "aliases": ["upregulation of polyferredoxin", "up-regulation of polyferredoxin"], "types": ["T044"], "canonical_name": "up regulation of polyferredoxin"}
{"concept_id": "C4233030", "aliases": ["up-regulation of mononuclear iron electron carrier", "upregulation of mononuclear iron electron carrier"], "types": ["T044"], "canonical_name": "up regulation of mononuclear iron electron carrier"}
{"concept_id": "C4233031", "aliases": ["up-regulation of monocluster bacterial-type ferredoxin", "upregulation of monocluster bacterial-type ferredoxin"], "types": ["T044"], "canonical_name": "up regulation of monocluster bacterial-type ferredoxin"}
{"concept_id": "C4233032", "aliases": ["up-regulation of iron-sulfur electron transfer carrier", "upregulation of iron-sulfur electron transfer carrier"], "types": ["T044"], "canonical_name": "up regulation of iron-sulfur electron transfer carrier"}
{"concept_id": "C4233033", "aliases": ["upregulation of high-potential iron-sulfur carrier", "up-regulation of high-potential iron-sulfur carrier"], "types": ["T044"], "canonical_name": "up regulation of high-potential iron-sulfur carrier"}
{"concept_id": "C4233034", "aliases": ["up-regulation of electron transfer flavoprotein, group II", "upregulation of electron transfer flavoprotein, group II"], "types": ["T044"], "canonical_name": "up regulation of electron transfer flavoprotein, group II"}
{"concept_id": "C4233035", "aliases": ["up-regulation of electron transfer flavoprotein, group I", "upregulation of electron transfer flavoprotein, group I"], "types": ["T044"], "canonical_name": "up regulation of electron transfer flavoprotein, group I"}
{"concept_id": "C4233036", "aliases": ["upregulation of electron transfer flavoprotein", "up-regulation of electron transfer flavoprotein"], "types": ["T044"], "canonical_name": "up regulation of electron transfer flavoprotein"}
{"concept_id": "C4233037", "aliases": ["up-regulation of electron donor activity", "upregulation of electron donor activity"], "types": ["T044"], "canonical_name": "up regulation of electron donor activity"}
{"concept_id": "C4233038", "aliases": ["upregulation of electron carrier, chlorophyll electron transport system", "up-regulation of electron carrier, chlorophyll electron transport system"], "types": ["T044"], "canonical_name": "up regulation of electron carrier, chlorophyll electron transport system"}
{"concept_id": "C4233039", "aliases": ["upregulation of electron acceptor activity", "up-regulation of electron acceptor activity"], "types": ["T044"], "canonical_name": "up regulation of electron acceptor activity"}
{"concept_id": "C4233040", "aliases": ["up-regulation of dicluster bacterial-type ferredoxin", "upregulation of dicluster bacterial-type ferredoxin"], "types": ["T044"], "canonical_name": "up regulation of dicluster bacterial-type ferredoxin"}
{"concept_id": "C4233041", "aliases": ["upregulation of copper electron carrier", "up-regulation of copper electron carrier"], "types": ["T044"], "canonical_name": "up regulation of copper electron carrier"}
{"concept_id": "C4233042", "aliases": ["upregulation of chloroplast-type ferredoxin", "up-regulation of chloroplast-type ferredoxin"], "types": ["T044"], "canonical_name": "up regulation of chloroplast-type ferredoxin"}
{"concept_id": "C4233043", "aliases": ["upregulation of bacterial-type ferredoxin", "up-regulation of bacterial-type ferredoxin"], "types": ["T044"], "canonical_name": "up regulation of bacterial-type ferredoxin"}
{"concept_id": "C4233044", "aliases": ["upregulation of azurin", "up-regulation of azurin"], "types": ["T044"], "canonical_name": "up regulation of azurin"}
{"concept_id": "C4233045", "aliases": ["upregulation of amicyanin", "up-regulation of amicyanin"], "types": ["T044"], "canonical_name": "up regulation of amicyanin"}
{"concept_id": "C4233046", "aliases": ["up-regulation of adrenodoxin-type ferredoxin", "upregulation of adrenodoxin-type ferredoxin"], "types": ["T044"], "canonical_name": "up regulation of adrenodoxin-type ferredoxin"}
{"concept_id": "C4233047", "aliases": ["up-regulation of 3Fe-4S/4Fe-4S electron transfer carrier", "upregulation of 3Fe-4S/4Fe-4S electron transfer carrier"], "types": ["T044"], "canonical_name": "up regulation of 3Fe-4S/4Fe-4S electron transfer carrier"}
{"concept_id": "C4233048", "aliases": ["upregulation of 2Fe-2S electron transfer carrier", "up-regulation of 2Fe-2S electron transfer carrier"], "types": ["T044"], "canonical_name": "up regulation of 2Fe-2S electron transfer carrier"}
{"concept_id": "C4233049", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of thioredoxin-like 2Fe-2S ferredoxin"}
{"concept_id": "C4233050", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of small blue copper electron carrier"}
{"concept_id": "C4233051", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of rubredoxin"}
{"concept_id": "C4233052", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of redox-active disulfide bond electron carrier"}
{"concept_id": "C4233053", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of polyferredoxin"}
{"concept_id": "C4233054", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of mononuclear iron electron carrier"}
{"concept_id": "C4233055", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of monocluster bacterial-type ferredoxin"}
{"concept_id": "C4233056", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of iron-sulfur electron transfer carrier"}
{"concept_id": "C4233057", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of high-potential iron-sulfur carrier"}
{"concept_id": "C4233058", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of electron transfer flavoprotein, group II"}
{"concept_id": "C4233059", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of electron transfer flavoprotein, group I"}
{"concept_id": "C4233060", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of electron transfer flavoprotein"}
{"concept_id": "C4233061", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of electron donor activity"}
{"concept_id": "C4233062", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of electron carrier, chlorophyll electron transport system"}
{"concept_id": "C4233063", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of electron acceptor activity"}
{"concept_id": "C4233064", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of dicluster bacterial-type ferredoxin"}
{"concept_id": "C4233065", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of copper electron carrier"}
{"concept_id": "C4233066", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of chloroplast-type ferredoxin"}
{"concept_id": "C4233067", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of bacterial-type ferredoxin"}
{"concept_id": "C4233068", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of azurin"}
{"concept_id": "C4233069", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of amicyanin"}
{"concept_id": "C4233070", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of adrenodoxin-type ferredoxin"}
{"concept_id": "C4233071", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 3Fe-4S/4Fe-4S electron transfer carrier"}
{"concept_id": "C4233072", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 2Fe-2S electron transfer carrier"}
{"concept_id": "C4233073", "aliases": [], "types": ["T044"], "canonical_name": "activation of thioredoxin-like 2Fe-2S ferredoxin"}
{"concept_id": "C4233074", "aliases": [], "types": ["T044"], "canonical_name": "activation of small blue copper electron carrier"}
{"concept_id": "C4233075", "aliases": [], "types": ["T044"], "canonical_name": "activation of rubredoxin"}
{"concept_id": "C4233076", "aliases": [], "types": ["T044"], "canonical_name": "activation of redox-active disulfide bond electron carrier"}
{"concept_id": "C4233077", "aliases": [], "types": ["T044"], "canonical_name": "activation of polyferredoxin"}
{"concept_id": "C4233078", "aliases": [], "types": ["T044"], "canonical_name": "activation of mononuclear iron electron carrier"}
{"concept_id": "C4233079", "aliases": [], "types": ["T044"], "canonical_name": "activation of monocluster bacterial-type ferredoxin"}
{"concept_id": "C4233080", "aliases": [], "types": ["T044"], "canonical_name": "activation of iron-sulfur electron transfer carrier"}
{"concept_id": "C4233081", "aliases": [], "types": ["T044"], "canonical_name": "activation of high-potential iron-sulfur carrier"}
{"concept_id": "C4233082", "aliases": [], "types": ["T044"], "canonical_name": "activation of electron transporter activity"}
{"concept_id": "C4233083", "aliases": [], "types": ["T044"], "canonical_name": "activation of electron transfer flavoprotein, group II"}
{"concept_id": "C4233084", "aliases": [], "types": ["T044"], "canonical_name": "activation of electron transfer flavoprotein, group I"}
{"concept_id": "C4233085", "aliases": [], "types": ["T044"], "canonical_name": "activation of electron transfer flavoprotein"}
{"concept_id": "C4233086", "aliases": [], "types": ["T044"], "canonical_name": "activation of electron donor activity"}
{"concept_id": "C4233087", "aliases": [], "types": ["T044"], "canonical_name": "activation of electron carrier, chlorophyll electron transport system"}
{"concept_id": "C4233088", "aliases": [], "types": ["T044"], "canonical_name": "activation of electron carrier activity"}
{"concept_id": "C4233089", "aliases": [], "types": ["T044"], "canonical_name": "activation of electron acceptor activity"}
{"concept_id": "C4233090", "aliases": [], "types": ["T044"], "canonical_name": "activation of dicluster bacterial-type ferredoxin"}
{"concept_id": "C4233091", "aliases": [], "types": ["T044"], "canonical_name": "activation of copper electron carrier"}
{"concept_id": "C4233092", "aliases": [], "types": ["T044"], "canonical_name": "activation of chloroplast-type ferredoxin"}
{"concept_id": "C4233093", "aliases": [], "types": ["T044"], "canonical_name": "activation of bacterial-type ferredoxin"}
{"concept_id": "C4233094", "aliases": [], "types": ["T044"], "canonical_name": "activation of azurin"}
{"concept_id": "C4233095", "aliases": [], "types": ["T044"], "canonical_name": "activation of amicyanin"}
{"concept_id": "C4233096", "aliases": [], "types": ["T044"], "canonical_name": "activation of adrenodoxin-type ferredoxin"}
{"concept_id": "C4233097", "aliases": [], "types": ["T044"], "canonical_name": "activation of 3Fe-4S/4Fe-4S electron transfer carrier"}
{"concept_id": "C4233098", "aliases": [], "types": ["T044"], "canonical_name": "activation of 2Fe-2S electron transfer carrier"}
{"concept_id": "C4233099", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of thioredoxin-like 2Fe-2S ferredoxin"}
{"concept_id": "C4233100", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of small blue copper electron carrier"}
{"concept_id": "C4233101", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of rubredoxin"}
{"concept_id": "C4233102", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of redox-active disulfide bond electron carrier"}
{"concept_id": "C4233103", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of polyferredoxin"}
{"concept_id": "C4233104", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of mononuclear iron electron carrier"}
{"concept_id": "C4233105", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of monocluster bacterial-type ferredoxin"}
{"concept_id": "C4233106", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of iron-sulfur electron transfer carrier"}
{"concept_id": "C4233107", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of high-potential iron-sulfur carrier"}
{"concept_id": "C4233108", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of electron transfer flavoprotein, group II"}
{"concept_id": "C4233109", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of electron transfer flavoprotein, group I"}
{"concept_id": "C4233110", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of electron transfer flavoprotein"}
{"concept_id": "C4233111", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of electron donor activity"}
{"concept_id": "C4233112", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of electron carrier, chlorophyll electron transport system"}
{"concept_id": "C4233113", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of electron acceptor activity"}
{"concept_id": "C4233114", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of dicluster bacterial-type ferredoxin"}
{"concept_id": "C4233115", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of copper electron carrier"}
{"concept_id": "C4233116", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of chloroplast-type ferredoxin"}
{"concept_id": "C4233117", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of bacterial-type ferredoxin"}
{"concept_id": "C4233118", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of azurin"}
{"concept_id": "C4233119", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of amicyanin"}
{"concept_id": "C4233120", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of adrenodoxin-type ferredoxin"}
{"concept_id": "C4233121", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 3Fe-4S/4Fe-4S electron transfer carrier"}
{"concept_id": "C4233122", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 2Fe-2S electron transfer carrier"}
{"concept_id": "C4233123", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of thioredoxin-like 2Fe-2S ferredoxin"}
{"concept_id": "C4233124", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of small blue copper electron carrier"}
{"concept_id": "C4233125", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of rubredoxin"}
{"concept_id": "C4233126", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of redox-active disulfide bond electron carrier"}
{"concept_id": "C4233127", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polyferredoxin"}
{"concept_id": "C4233128", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mononuclear iron electron carrier"}
{"concept_id": "C4233129", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of monocluster bacterial-type ferredoxin"}
{"concept_id": "C4233130", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of iron-sulfur electron transfer carrier"}
{"concept_id": "C4233131", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of high-potential iron-sulfur carrier"}
{"concept_id": "C4233132", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of electron transporter activity"}
{"concept_id": "C4233133", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of electron transfer flavoprotein, group II"}
{"concept_id": "C4233134", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of electron transfer flavoprotein, group I"}
{"concept_id": "C4233135", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of electron transfer flavoprotein"}
{"concept_id": "C4233136", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of electron donor activity"}
{"concept_id": "C4233137", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of electron carrier, chlorophyll electron transport system"}
{"concept_id": "C4233138", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of electron carrier activity"}
{"concept_id": "C4233139", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of electron acceptor activity"}
{"concept_id": "C4233140", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of dicluster bacterial-type ferredoxin"}
{"concept_id": "C4233141", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of copper electron carrier"}
{"concept_id": "C4233142", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of chloroplast-type ferredoxin"}
{"concept_id": "C4233143", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bacterial-type ferredoxin"}
{"concept_id": "C4233144", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of azurin"}
{"concept_id": "C4233145", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amicyanin"}
{"concept_id": "C4233146", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of adrenodoxin-type ferredoxin"}
{"concept_id": "C4233147", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 3Fe-4S/4Fe-4S electron transfer carrier"}
{"concept_id": "C4233148", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 2Fe-2S electron transfer carrier"}
{"concept_id": "C4233149", "aliases": ["down-regulation of thioredoxin-like 2Fe-2S ferredoxin", "downregulation of thioredoxin-like 2Fe-2S ferredoxin"], "types": ["T044"], "canonical_name": "down regulation of thioredoxin-like 2Fe-2S ferredoxin"}
{"concept_id": "C4233150", "aliases": ["downregulation of small blue copper electron carrier", "down-regulation of small blue copper electron carrier"], "types": ["T044"], "canonical_name": "down regulation of small blue copper electron carrier"}
{"concept_id": "C4233151", "aliases": ["down-regulation of rubredoxin", "downregulation of rubredoxin"], "types": ["T044"], "canonical_name": "down regulation of rubredoxin"}
{"concept_id": "C4233152", "aliases": ["down-regulation of redox-active disulfide bond electron carrier", "downregulation of redox-active disulfide bond electron carrier"], "types": ["T044"], "canonical_name": "down regulation of redox-active disulfide bond electron carrier"}
{"concept_id": "C4233153", "aliases": ["downregulation of polyferredoxin", "down-regulation of polyferredoxin"], "types": ["T044"], "canonical_name": "down regulation of polyferredoxin"}
{"concept_id": "C4233154", "aliases": ["downregulation of mononuclear iron electron carrier", "down-regulation of mononuclear iron electron carrier"], "types": ["T044"], "canonical_name": "down regulation of mononuclear iron electron carrier"}
{"concept_id": "C4233155", "aliases": ["down-regulation of monocluster bacterial-type ferredoxin", "downregulation of monocluster bacterial-type ferredoxin"], "types": ["T044"], "canonical_name": "down regulation of monocluster bacterial-type ferredoxin"}
{"concept_id": "C4233156", "aliases": ["downregulation of iron-sulfur electron transfer carrier", "down-regulation of iron-sulfur electron transfer carrier"], "types": ["T044"], "canonical_name": "down regulation of iron-sulfur electron transfer carrier"}
{"concept_id": "C4233157", "aliases": ["down-regulation of high-potential iron-sulfur carrier", "downregulation of high-potential iron-sulfur carrier"], "types": ["T044"], "canonical_name": "down regulation of high-potential iron-sulfur carrier"}
{"concept_id": "C4233158", "aliases": ["downregulation of electron transfer flavoprotein, group II", "down-regulation of electron transfer flavoprotein, group II"], "types": ["T044"], "canonical_name": "down regulation of electron transfer flavoprotein, group II"}
{"concept_id": "C4233159", "aliases": ["downregulation of electron transfer flavoprotein, group I", "down-regulation of electron transfer flavoprotein, group I"], "types": ["T044"], "canonical_name": "down regulation of electron transfer flavoprotein, group I"}
{"concept_id": "C4233160", "aliases": ["downregulation of electron transfer flavoprotein", "down-regulation of electron transfer flavoprotein"], "types": ["T044"], "canonical_name": "down regulation of electron transfer flavoprotein"}
{"concept_id": "C4233161", "aliases": ["down-regulation of electron donor activity", "downregulation of electron donor activity"], "types": ["T044"], "canonical_name": "down regulation of electron donor activity"}
{"concept_id": "C4233162", "aliases": ["down-regulation of electron carrier, chlorophyll electron transport system", "downregulation of electron carrier, chlorophyll electron transport system"], "types": ["T044"], "canonical_name": "down regulation of electron carrier, chlorophyll electron transport system"}
{"concept_id": "C4233163", "aliases": ["down-regulation of electron acceptor activity", "downregulation of electron acceptor activity"], "types": ["T044"], "canonical_name": "down regulation of electron acceptor activity"}
{"concept_id": "C4233164", "aliases": ["down-regulation of dicluster bacterial-type ferredoxin", "downregulation of dicluster bacterial-type ferredoxin"], "types": ["T044"], "canonical_name": "down regulation of dicluster bacterial-type ferredoxin"}
{"concept_id": "C4233165", "aliases": ["down-regulation of copper electron carrier", "downregulation of copper electron carrier"], "types": ["T044"], "canonical_name": "down regulation of copper electron carrier"}
{"concept_id": "C4233166", "aliases": ["downregulation of chloroplast-type ferredoxin", "down-regulation of chloroplast-type ferredoxin"], "types": ["T044"], "canonical_name": "down regulation of chloroplast-type ferredoxin"}
{"concept_id": "C4233167", "aliases": ["downregulation of bacterial-type ferredoxin", "down-regulation of bacterial-type ferredoxin"], "types": ["T044"], "canonical_name": "down regulation of bacterial-type ferredoxin"}
{"concept_id": "C4233168", "aliases": ["down-regulation of azurin", "downregulation of azurin"], "types": ["T044"], "canonical_name": "down regulation of azurin"}
{"concept_id": "C4233169", "aliases": ["down-regulation of amicyanin", "downregulation of amicyanin"], "types": ["T044"], "canonical_name": "down regulation of amicyanin"}
{"concept_id": "C4233170", "aliases": ["down-regulation of adrenodoxin-type ferredoxin", "downregulation of adrenodoxin-type ferredoxin"], "types": ["T044"], "canonical_name": "down regulation of adrenodoxin-type ferredoxin"}
{"concept_id": "C4233171", "aliases": ["downregulation of 3Fe-4S/4Fe-4S electron transfer carrier", "down-regulation of 3Fe-4S/4Fe-4S electron transfer carrier"], "types": ["T044"], "canonical_name": "down regulation of 3Fe-4S/4Fe-4S electron transfer carrier"}
{"concept_id": "C4233172", "aliases": ["downregulation of 2Fe-2S electron transfer carrier", "down-regulation of 2Fe-2S electron transfer carrier"], "types": ["T044"], "canonical_name": "down regulation of 2Fe-2S electron transfer carrier"}
{"concept_id": "C4233173", "aliases": [], "types": ["T044"], "canonical_name": "regulation of thioredoxin-like 2Fe-2S ferredoxin"}
{"concept_id": "C4233174", "aliases": [], "types": ["T044"], "canonical_name": "regulation of small blue copper electron carrier"}
{"concept_id": "C4233175", "aliases": [], "types": ["T044"], "canonical_name": "regulation of rubredoxin"}
{"concept_id": "C4233176", "aliases": [], "types": ["T044"], "canonical_name": "regulation of redox-active disulfide bond electron carrier"}
{"concept_id": "C4233177", "aliases": [], "types": ["T044"], "canonical_name": "regulation of polyferredoxin"}
{"concept_id": "C4233178", "aliases": [], "types": ["T044"], "canonical_name": "regulation of mononuclear iron electron carrier"}
{"concept_id": "C4233179", "aliases": [], "types": ["T044"], "canonical_name": "regulation of monocluster bacterial-type ferredoxin"}
{"concept_id": "C4233180", "aliases": [], "types": ["T044"], "canonical_name": "regulation of iron-sulfur electron transfer carrier"}
{"concept_id": "C4233181", "aliases": [], "types": ["T044"], "canonical_name": "regulation of high-potential iron-sulfur carrier"}
{"concept_id": "C4233182", "aliases": [], "types": ["T044"], "canonical_name": "regulation of electron transfer flavoprotein, group II"}
{"concept_id": "C4233183", "aliases": [], "types": ["T044"], "canonical_name": "regulation of electron transfer flavoprotein, group I"}
{"concept_id": "C4233184", "aliases": [], "types": ["T044"], "canonical_name": "regulation of electron transfer flavoprotein"}
{"concept_id": "C4233185", "aliases": [], "types": ["T044"], "canonical_name": "regulation of electron donor activity"}
{"concept_id": "C4233186", "aliases": [], "types": ["T044"], "canonical_name": "regulation of electron carrier, chlorophyll electron transport system"}
{"concept_id": "C4233187", "aliases": [], "types": ["T044"], "canonical_name": "regulation of electron acceptor activity"}
{"concept_id": "C4233188", "aliases": [], "types": ["T044"], "canonical_name": "regulation of dicluster bacterial-type ferredoxin"}
{"concept_id": "C4233189", "aliases": [], "types": ["T044"], "canonical_name": "regulation of copper electron carrier"}
{"concept_id": "C4233190", "aliases": [], "types": ["T044"], "canonical_name": "regulation of chloroplast-type ferredoxin"}
{"concept_id": "C4233191", "aliases": [], "types": ["T044"], "canonical_name": "regulation of bacterial-type ferredoxin"}
{"concept_id": "C4233192", "aliases": [], "types": ["T044"], "canonical_name": "regulation of azurin"}
{"concept_id": "C4233193", "aliases": [], "types": ["T044"], "canonical_name": "regulation of amicyanin"}
{"concept_id": "C4233194", "aliases": [], "types": ["T044"], "canonical_name": "regulation of adrenodoxin-type ferredoxin"}
{"concept_id": "C4233195", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 3Fe-4S/4Fe-4S electron transfer carrier"}
{"concept_id": "C4233196", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 2Fe-2S electron transfer carrier"}
{"concept_id": "C4233197", "aliases": [], "types": ["T044"], "canonical_name": "activation of intestinal lipid absorption"}
{"concept_id": "C4233198", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of intestinal lipid absorption"}
{"concept_id": "C4233199", "aliases": [], "types": ["T043"], "canonical_name": "activation of replicative senescence"}
{"concept_id": "C4233200", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of replicative senescence"}
{"concept_id": "C4233207", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Wnt-induced Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233208", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Wnt-induced Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233209", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of WNT-FZD-LRP6 complex formation"}
{"concept_id": "C4233210", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of WNT-FZD-LRP6 complex assembly"}
{"concept_id": "C4233211", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of WNT-FZD-LRP5 complex formation"}
{"concept_id": "C4233212", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of WNT-FZD-LRP5 complex assembly"}
{"concept_id": "C4233213", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233214", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233215", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-induced Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233216", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-induced Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233217", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of WNT-FZD-LRP6 complex formation"}
{"concept_id": "C4233218", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of WNT-FZD-LRP6 complex assembly"}
{"concept_id": "C4233219", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-FZD-LRP5/6 trimeric complex formation"}
{"concept_id": "C4233220", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-FZD-LRP5/6 trimeric complex assembly"}
{"concept_id": "C4233221", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of WNT-FZD-LRP5 complex formation"}
{"concept_id": "C4233222", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of WNT-FZD-LRP5 complex assembly"}
{"concept_id": "C4233223", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233224", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233225", "aliases": ["downregulation of Wnt-induced Frizzled-LRP5/6 complex formation", "down-regulation of Wnt-induced Frizzled-LRP5/6 complex formation"], "types": ["T043"], "canonical_name": "down regulation of Wnt-induced Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233226", "aliases": ["downregulation of Wnt-induced Frizzled-LRP5/6 complex assembly", "down-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly"], "types": ["T043"], "canonical_name": "down regulation of Wnt-induced Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233227", "aliases": ["downregulation of WNT-FZD-LRP6 complex formation", "down-regulation of WNT-FZD-LRP6 complex formation"], "types": ["T043"], "canonical_name": "down regulation of WNT-FZD-LRP6 complex formation"}
{"concept_id": "C4233228", "aliases": ["down-regulation of WNT-FZD-LRP6 complex assembly", "downregulation of WNT-FZD-LRP6 complex assembly"], "types": ["T043"], "canonical_name": "down regulation of WNT-FZD-LRP6 complex assembly"}
{"concept_id": "C4233229", "aliases": ["down-regulation of WNT-FZD-LRP5 complex formation", "downregulation of WNT-FZD-LRP5 complex formation"], "types": ["T043"], "canonical_name": "down regulation of WNT-FZD-LRP5 complex formation"}
{"concept_id": "C4233230", "aliases": ["down-regulation of WNT-FZD-LRP5 complex assembly", "downregulation of WNT-FZD-LRP5 complex assembly"], "types": ["T043"], "canonical_name": "down regulation of WNT-FZD-LRP5 complex assembly"}
{"concept_id": "C4233231", "aliases": ["down-regulation of Frizzled-LRP5/6 complex formation", "downregulation of Frizzled-LRP5/6 complex formation"], "types": ["T043"], "canonical_name": "down regulation of Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233262", "aliases": [], "types": ["T043"], "canonical_name": "activation of AMPA receptor clustering"}
{"concept_id": "C4233263", "aliases": [], "types": ["T043"], "canonical_name": "activation of AMPA glutamate receptor clustering"}
{"concept_id": "C4233264", "aliases": [], "types": ["T043"], "canonical_name": "activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering"}
{"concept_id": "C4233265", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of AMPA receptor clustering"}
{"concept_id": "C4233266", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of AMPA glutamate receptor clustering"}
{"concept_id": "C4233267", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering"}
{"concept_id": "C4233268", "aliases": ["up-regulation of CMA", "upregulation of CMA"], "types": ["T043"], "canonical_name": "up regulation of CMA"}
{"concept_id": "C4233269", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of CMA"}
{"concept_id": "C4233270", "aliases": [], "types": ["T043"], "canonical_name": "activation of CMA"}
{"concept_id": "C4233271", "aliases": [], "types": ["T043"], "canonical_name": "activation of chaperone-mediated autophagy"}
{"concept_id": "C4233272", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of CMA"}
{"concept_id": "C4233273", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of CMA"}
{"concept_id": "C4233274", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chaperone-mediated autophagy"}
{"concept_id": "C4233275", "aliases": ["down-regulation of CMA", "downregulation of CMA"], "types": ["T043"], "canonical_name": "down regulation of CMA"}
{"concept_id": "C4233276", "aliases": ["regulation of CMA"], "types": ["T043"], "canonical_name": "regulation of chaperone-mediated autophagy", "definition": "Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]"}
{"concept_id": "C4233277", "aliases": [], "types": ["T044"], "canonical_name": "23S APC complex binding"}
{"concept_id": "C4233278", "aliases": ["upregulation of Wnt-induced Frizzled-LRP5/6 complex formation", "up-regulation of Wnt-induced Frizzled-LRP5/6 complex formation"], "types": ["T043"], "canonical_name": "up regulation of Wnt-induced Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233279", "aliases": ["upregulation of Wnt-induced Frizzled-LRP5/6 complex assembly", "up-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly"], "types": ["T043"], "canonical_name": "up regulation of Wnt-induced Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233280", "aliases": ["up-regulation of WNT-FZD-LRP6 complex formation", "upregulation of WNT-FZD-LRP6 complex formation"], "types": ["T043"], "canonical_name": "up regulation of WNT-FZD-LRP6 complex formation"}
{"concept_id": "C4233281", "aliases": ["upregulation of WNT-FZD-LRP6 complex assembly", "up-regulation of WNT-FZD-LRP6 complex assembly"], "types": ["T043"], "canonical_name": "up regulation of WNT-FZD-LRP6 complex assembly"}
{"concept_id": "C4233282", "aliases": ["upregulation of WNT-FZD-LRP5 complex formation", "up-regulation of WNT-FZD-LRP5 complex formation"], "types": ["T043"], "canonical_name": "up regulation of WNT-FZD-LRP5 complex formation"}
{"concept_id": "C4233283", "aliases": ["up-regulation of WNT-FZD-LRP5 complex assembly", "upregulation of WNT-FZD-LRP5 complex assembly"], "types": ["T043"], "canonical_name": "up regulation of WNT-FZD-LRP5 complex assembly"}
{"concept_id": "C4233284", "aliases": ["upregulation of Frizzled-LRP5/6 complex formation", "up-regulation of Frizzled-LRP5/6 complex formation"], "types": ["T043"], "canonical_name": "up regulation of Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233285", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt-induced Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233286", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt-induced Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233287", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of WNT-FZD-LRP6 complex formation"}
{"concept_id": "C4233288", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of WNT-FZD-LRP6 complex assembly"}
{"concept_id": "C4233289", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of WNT-FZD-LRP5 complex formation"}
{"concept_id": "C4233290", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of WNT-FZD-LRP5 complex assembly"}
{"concept_id": "C4233291", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233292", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233293", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-induced Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233294", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-induced Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233295", "aliases": [], "types": ["T043"], "canonical_name": "activation of WNT-FZD-LRP6 complex formation"}
{"concept_id": "C4233296", "aliases": [], "types": ["T043"], "canonical_name": "activation of WNT-FZD-LRP6 complex assembly"}
{"concept_id": "C4233297", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-FZD-LRP5/6 trimeric complex formation"}
{"concept_id": "C4233298", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-FZD-LRP5/6 trimeric complex assembly"}
{"concept_id": "C4233299", "aliases": [], "types": ["T043"], "canonical_name": "activation of WNT-FZD-LRP5 complex formation"}
{"concept_id": "C4233300", "aliases": [], "types": ["T043"], "canonical_name": "activation of WNT-FZD-LRP5 complex assembly"}
{"concept_id": "C4233301", "aliases": [], "types": ["T043"], "canonical_name": "activation of Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233302", "aliases": [], "types": ["T043"], "canonical_name": "activation of Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233303", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Wnt-induced Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233304", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Wnt-induced Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233305", "aliases": [], "types": ["T043"], "canonical_name": "regulation of WNT-FZD-LRP6 complex formation"}
{"concept_id": "C4233306", "aliases": [], "types": ["T043"], "canonical_name": "regulation of WNT-FZD-LRP6 complex assembly"}
{"concept_id": "C4233307", "aliases": [], "types": ["T043"], "canonical_name": "regulation of WNT-FZD-LRP5 complex formation"}
{"concept_id": "C4233308", "aliases": [], "types": ["T043"], "canonical_name": "regulation of WNT-FZD-LRP5 complex assembly"}
{"concept_id": "C4233309", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Wnt receptor complex assembly"}
{"concept_id": "C4233310", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233311", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233312", "aliases": ["upregulation of granulosa cell of ovary apoptosis", "up-regulation of granulosa cell of ovary apoptosis"], "types": ["T043"], "canonical_name": "up regulation of granulosa cell of ovary apoptosis"}
{"concept_id": "C4233313", "aliases": ["up-regulation of granulosa cell apoptosis", "upregulation of granulosa cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of granulosa cell apoptosis"}
{"concept_id": "C4233314", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of granulosa cell of ovary apoptosis"}
{"concept_id": "C4233315", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of granulosa cell apoptosis"}
{"concept_id": "C4233316", "aliases": [], "types": ["T043"], "canonical_name": "activation of granulosa cell of ovary apoptotic process"}
{"concept_id": "C4233317", "aliases": [], "types": ["T043"], "canonical_name": "activation of granulosa cell of ovary apoptosis"}
{"concept_id": "C4233318", "aliases": [], "types": ["T043"], "canonical_name": "activation of granulosa cell apoptotic process"}
{"concept_id": "C4233319", "aliases": [], "types": ["T043"], "canonical_name": "activation of granulosa cell apoptosis"}
{"concept_id": "C4233320", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of granulosa cell of ovary apoptosis"}
{"concept_id": "C4233321", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of granulosa cell apoptosis"}
{"concept_id": "C4233322", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of granulosa cell of ovary apoptotic process"}
{"concept_id": "C4233323", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of granulosa cell of ovary apoptosis"}
{"concept_id": "C4233324", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of granulosa cell apoptotic process"}
{"concept_id": "C4233325", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of granulosa cell apoptosis"}
{"concept_id": "C4233326", "aliases": ["downregulation of granulosa cell of ovary apoptosis", "down-regulation of granulosa cell of ovary apoptosis"], "types": ["T043"], "canonical_name": "down regulation of granulosa cell of ovary apoptosis"}
{"concept_id": "C4233327", "aliases": ["down-regulation of granulosa cell apoptosis", "downregulation of granulosa cell apoptosis"], "types": ["T043"], "canonical_name": "down regulation of granulosa cell apoptosis"}
{"concept_id": "C4233328", "aliases": [], "types": ["T043"], "canonical_name": "regulation of granulosa cell of ovary apoptosis"}
{"concept_id": "C4233329", "aliases": [], "types": ["T043"], "canonical_name": "regulation of granulosa cell apoptosis"}
{"concept_id": "C4233330", "aliases": [], "types": ["T043"], "canonical_name": "activation of VSMC proliferation"}
{"concept_id": "C4233331", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular smooth muscle cell proliferation"}
{"concept_id": "C4233332", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of VSMC proliferation"}
{"concept_id": "C4233333", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vascular smooth muscle cell proliferation"}
{"concept_id": "C4233334", "aliases": ["activation of protein localization to cell-cell adherens junction"], "types": ["T044"], "canonical_name": "activation of protein localisation to cell-cell adherens junction"}
{"concept_id": "C4233335", "aliases": ["activation of protein localization in cell-cell adherens junction"], "types": ["T044"], "canonical_name": "activation of protein localisation in cell-cell adherens junction"}
{"concept_id": "C4233336", "aliases": ["inhibition of protein localization to cell-cell adherens junction"], "types": ["T044"], "canonical_name": "inhibition of protein localisation to cell-cell adherens junction"}
{"concept_id": "C4233337", "aliases": ["inhibition of protein localization in cell-cell adherens junction"], "types": ["T044"], "canonical_name": "inhibition of protein localisation in cell-cell adherens junction"}
{"concept_id": "C4233338", "aliases": [], "types": ["T044"], "canonical_name": "Wnt-induced Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233339", "aliases": ["Wnt-FZD-LRP5/6 trimeric complex assembly", "Wnt-FZD-LRP5/6 trimeric complex formation", "Wnt-induced Frizzled-LRP5/6 complex assembly"], "types": ["T044"], "canonical_name": "Wnt-Frizzled-LRP5/6 complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a Wnt-Frizzled-LRP5/6 complex. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11448771]"}
{"concept_id": "C4233340", "aliases": [], "types": ["T044"], "canonical_name": "WNT-FZD-LRP6 complex formation"}
{"concept_id": "C4233341", "aliases": [], "types": ["T044"], "canonical_name": "WNT-FZD-LRP6 complex assembly"}
{"concept_id": "C4233342", "aliases": [], "types": ["T044"], "canonical_name": "WNT-FZD-LRP5 complex formation"}
{"concept_id": "C4233343", "aliases": [], "types": ["T044"], "canonical_name": "WNT-FZD-LRP5 complex assembly"}
{"concept_id": "C4233344", "aliases": [], "types": ["T044"], "canonical_name": "Wnt receptor complex assembly"}
{"concept_id": "C4233345", "aliases": [], "types": ["T044"], "canonical_name": "Frizzled-LRP5/6 complex formation"}
{"concept_id": "C4233346", "aliases": [], "types": ["T044"], "canonical_name": "Frizzled-LRP5/6 complex assembly"}
{"concept_id": "C4233347", "aliases": [], "types": ["T043"], "canonical_name": "granulosa cell of ovary apoptosis"}
{"concept_id": "C4233348", "aliases": [], "types": ["T043"], "canonical_name": "granulosa cell apoptosis"}
{"concept_id": "C4233349", "aliases": [], "types": ["T043"], "canonical_name": "activation of acinous cell proliferation"}
{"concept_id": "C4233350", "aliases": [], "types": ["T043"], "canonical_name": "activation of acinic cell proliferation"}
{"concept_id": "C4233351", "aliases": [], "types": ["T043"], "canonical_name": "activation of acinar cell proliferation"}
{"concept_id": "C4233352", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of acinous cell proliferation"}
{"concept_id": "C4233353", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of acinic cell proliferation"}
{"concept_id": "C4233354", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of acinar cell proliferation"}
{"concept_id": "C4233355", "aliases": [], "types": ["T042"], "canonical_name": "activation of vascular smooth muscle contraction"}
{"concept_id": "C4233356", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of vascular smooth muscle contraction"}
{"concept_id": "C4233357", "aliases": [], "types": ["T042"], "canonical_name": "mesencephalon morphogenesis"}
{"concept_id": "C4233358", "aliases": [], "types": ["T042"], "canonical_name": "MB morphogenesis"}
{"concept_id": "C4233359", "aliases": [], "types": ["T043"], "canonical_name": "activation of type B pancreatic cell proliferation"}
{"concept_id": "C4233360", "aliases": [], "types": ["T043"], "canonical_name": "activation of pancreatic beta cell proliferation"}
{"concept_id": "C4233361", "aliases": [], "types": ["T043"], "canonical_name": "activation of pancreatic B cell proliferation"}
{"concept_id": "C4233362", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of type B pancreatic cell proliferation"}
{"concept_id": "C4233363", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pancreatic beta cell proliferation"}
{"concept_id": "C4233364", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pancreatic B cell proliferation"}
{"concept_id": "C4233365", "aliases": [], "types": ["T045"], "canonical_name": "activation of cytoplasmic translational initiation"}
{"concept_id": "C4233366", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cytoplasmic translational initiation"}
{"concept_id": "C4233367", "aliases": [], "types": ["T044"], "canonical_name": "activation of spindle disassembly during mitosis"}
{"concept_id": "C4233368", "aliases": [], "types": ["T044"], "canonical_name": "activation of spindle degradation during mitosis"}
{"concept_id": "C4233369", "aliases": [], "types": ["T044"], "canonical_name": "activation of spindle breakdown during mitosis"}
{"concept_id": "C4233370", "aliases": [], "types": ["T044"], "canonical_name": "activation of mitotic spindle disassembly"}
{"concept_id": "C4233371", "aliases": [], "types": ["T044"], "canonical_name": "activation of mitotic spindle degradation"}
{"concept_id": "C4233372", "aliases": [], "types": ["T044"], "canonical_name": "activation of mitotic spindle catabolism"}
{"concept_id": "C4233373", "aliases": [], "types": ["T044"], "canonical_name": "activation of mitotic spindle breakdown"}
{"concept_id": "C4233374", "aliases": ["upregulation of metalloendoproteinase activity", "up-regulation of metalloendoproteinase activity"], "types": ["T044"], "canonical_name": "up regulation of metalloendoproteinase activity"}
{"concept_id": "C4233375", "aliases": ["up-regulation of metalloendoprotease activity", "upregulation of metalloendoprotease activity"], "types": ["T044"], "canonical_name": "up regulation of metalloendoprotease activity"}
{"concept_id": "C4233376", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of metalloendoproteinase activity"}
{"concept_id": "C4233377", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of metalloendoprotease activity"}
{"concept_id": "C4233378", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoproteinase activity"}
{"concept_id": "C4233379", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendoprotease activity"}
{"concept_id": "C4233380", "aliases": [], "types": ["T044"], "canonical_name": "activation of metalloendopeptidase activity"}
{"concept_id": "C4233381", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of metalloendoproteinase activity"}
{"concept_id": "C4233382", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoproteinase activity"}
{"concept_id": "C4233383", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendoprotease activity"}
{"concept_id": "C4233384", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of metalloendopeptidase activity"}
{"concept_id": "C4233385", "aliases": ["downregulation of metalloendoproteinase activity", "down-regulation of metalloendoproteinase activity"], "types": ["T044"], "canonical_name": "down regulation of metalloendoproteinase activity"}
{"concept_id": "C4233386", "aliases": ["down-regulation of metalloendoprotease activity", "downregulation of metalloendoprotease activity"], "types": ["T044"], "canonical_name": "down regulation of metalloendoprotease activity"}
{"concept_id": "C4233387", "aliases": [], "types": ["T044"], "canonical_name": "regulation of metalloendoproteinase activity"}
{"concept_id": "C4233388", "aliases": [], "types": ["T044"], "canonical_name": "regulation of metalloendoprotease activity"}
{"concept_id": "C4233389", "aliases": [], "types": ["T045"], "canonical_name": "aminoacyl-tRNA binding"}
{"concept_id": "C4233390", "aliases": [], "types": ["T043"], "canonical_name": "activation of somatic stem cell renewal"}
{"concept_id": "C4233391", "aliases": [], "types": ["T043"], "canonical_name": "activation of somatic stem cell division"}
{"concept_id": "C4233392", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of somatic stem cell renewal"}
{"concept_id": "C4233393", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of somatic stem cell division"}
{"concept_id": "C4233394", "aliases": [], "types": ["T040"], "canonical_name": "activation of somatic stem cell population maintenance"}
{"concept_id": "C4233395", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of somatic stem cell population maintenance"}
{"concept_id": "C4233396", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell differentiation involved in maintenance of pluripotency"}
{"concept_id": "C4233397", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell differentiation involved in stem cell population maintenance"}
{"concept_id": "C4233398", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell differentiation involved in maintenance of pluripotency"}
{"concept_id": "C4233399", "aliases": ["down-regulation of cell differentiation involved in maintenance of pluripotency", "downregulation of cell differentiation involved in maintenance of pluripotency"], "types": ["T043"], "canonical_name": "down regulation of cell differentiation involved in maintenance of pluripotency"}
{"concept_id": "C4233400", "aliases": [], "types": ["T043"], "canonical_name": "ATP efflux"}
{"concept_id": "C4233401", "aliases": ["up-regulation of E3", "upregulation of E3"], "types": ["T044"], "canonical_name": "up regulation of E3"}
{"concept_id": "C4233402", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of E3"}
{"concept_id": "C4233403", "aliases": [], "types": ["T044"], "canonical_name": "activation of ubiquitin protein ligase activity"}
{"concept_id": "C4233404", "aliases": [], "types": ["T044"], "canonical_name": "activation of ubiquitin ligase activity"}
{"concept_id": "C4233405", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein ubiquitination activity"}
{"concept_id": "C4233406", "aliases": [], "types": ["T044"], "canonical_name": "activation of E3"}
{"concept_id": "C4233407", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of E3"}
{"concept_id": "C4233408", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ubiquitin protein ligase activity"}
{"concept_id": "C4233409", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ubiquitin ligase activity"}
{"concept_id": "C4233410", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein ubiquitination activity"}
{"concept_id": "C4233411", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of E3"}
{"concept_id": "C4233412", "aliases": ["down-regulation of E3", "downregulation of E3"], "types": ["T044"], "canonical_name": "down regulation of E3"}
{"concept_id": "C4233413", "aliases": [], "types": ["T044"], "canonical_name": "regulation of E3"}
{"concept_id": "C4233414", "aliases": [], "types": ["T040"], "canonical_name": "activation of sensory perception of bitter taste"}
{"concept_id": "C4233415", "aliases": [], "types": ["T040"], "canonical_name": "activation of bitter taste perception"}
{"concept_id": "C4233416", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of sensory perception of bitter taste"}
{"concept_id": "C4233417", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of bitter taste perception"}
{"concept_id": "C4233418", "aliases": [], "types": ["T040"], "canonical_name": "activation of sweet taste perception"}
{"concept_id": "C4233419", "aliases": [], "types": ["T040"], "canonical_name": "activation of sensory perception of sweet taste"}
{"concept_id": "C4233420", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of sweet taste perception"}
{"concept_id": "C4233421", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of sensory perception of sweet taste"}
{"concept_id": "C4233422", "aliases": [], "types": ["T039"], "canonical_name": "activation of lung alveolus development"}
{"concept_id": "C4233423", "aliases": [], "types": ["T039"], "canonical_name": "activation of alveologenesis"}
{"concept_id": "C4233424", "aliases": [], "types": ["T039"], "canonical_name": "activation of alveolarization"}
{"concept_id": "C4233425", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of lung alveolus development"}
{"concept_id": "C4233426", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of alveologenesis"}
{"concept_id": "C4233427", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of alveolarization"}
{"concept_id": "C4233428", "aliases": ["upregulation of fat cell apoptosis", "up-regulation of fat cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of fat cell apoptosis"}
{"concept_id": "C4233429", "aliases": ["upregulation of adipose cell apoptosis", "up-regulation of adipose cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of adipose cell apoptosis"}
{"concept_id": "C4233430", "aliases": ["up-regulation of adipocyte apoptosis", "upregulation of adipocyte apoptosis"], "types": ["T043"], "canonical_name": "up regulation of adipocyte apoptosis"}
{"concept_id": "C4233431", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of fat cell apoptosis"}
{"concept_id": "C4233432", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of adipose cell apoptosis"}
{"concept_id": "C4233433", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of adipocyte apoptosis"}
{"concept_id": "C4233434", "aliases": [], "types": ["T043"], "canonical_name": "activation of fat cell apoptotic process"}
{"concept_id": "C4233435", "aliases": [], "types": ["T043"], "canonical_name": "activation of fat cell apoptosis"}
{"concept_id": "C4233436", "aliases": [], "types": ["T043"], "canonical_name": "activation of adipose cell apoptotic process"}
{"concept_id": "C4233437", "aliases": [], "types": ["T043"], "canonical_name": "activation of adipose cell apoptosis"}
{"concept_id": "C4233438", "aliases": [], "types": ["T043"], "canonical_name": "activation of adipocyte apoptotic process"}
{"concept_id": "C4233439", "aliases": [], "types": ["T043"], "canonical_name": "activation of adipocyte apoptosis"}
{"concept_id": "C4233440", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of fat cell apoptosis"}
{"concept_id": "C4233441", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of adipose cell apoptosis"}
{"concept_id": "C4233442", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of adipocyte apoptosis"}
{"concept_id": "C4233443", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fat cell apoptotic process"}
{"concept_id": "C4233444", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fat cell apoptosis"}
{"concept_id": "C4233445", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adipose cell apoptotic process"}
{"concept_id": "C4233446", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adipose cell apoptosis"}
{"concept_id": "C4233447", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adipocyte apoptotic process"}
{"concept_id": "C4233448", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adipocyte apoptosis"}
{"concept_id": "C4233449", "aliases": ["down-regulation of fat cell apoptosis", "downregulation of fat cell apoptosis"], "types": ["T043"], "canonical_name": "down regulation of fat cell apoptosis"}
{"concept_id": "C4233450", "aliases": ["down-regulation of adipose cell apoptosis", "downregulation of adipose cell apoptosis"], "types": ["T043"], "canonical_name": "down regulation of adipose cell apoptosis"}
{"concept_id": "C4233451", "aliases": ["downregulation of adipocyte apoptosis", "down-regulation of adipocyte apoptosis"], "types": ["T043"], "canonical_name": "down regulation of adipocyte apoptosis"}
{"concept_id": "C4233452", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fat cell apoptosis"}
{"concept_id": "C4233453", "aliases": [], "types": ["T043"], "canonical_name": "regulation of adipose cell apoptosis"}
{"concept_id": "C4233454", "aliases": [], "types": ["T043"], "canonical_name": "regulation of adipocyte apoptosis"}
{"concept_id": "C4233459", "aliases": ["up-regulation of podocyte apoptosis", "upregulation of podocyte apoptosis"], "types": ["T043"], "canonical_name": "up regulation of podocyte apoptosis"}
{"concept_id": "C4233460", "aliases": ["upregulation of glomerular visceral epithelial cell apoptosis", "up-regulation of glomerular visceral epithelial cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of glomerular visceral epithelial cell apoptosis"}
{"concept_id": "C4233461", "aliases": ["up-regulation of glomerular podocyte apoptosis", "upregulation of glomerular podocyte apoptosis"], "types": ["T043"], "canonical_name": "up regulation of glomerular podocyte apoptosis"}
{"concept_id": "C4233462", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of podocyte apoptosis"}
{"concept_id": "C4233463", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glomerular visceral epithelial cell apoptosis"}
{"concept_id": "C4233464", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glomerular podocyte apoptosis"}
{"concept_id": "C4233465", "aliases": [], "types": ["T043"], "canonical_name": "activation of podocyte apoptotic process"}
{"concept_id": "C4233466", "aliases": [], "types": ["T043"], "canonical_name": "activation of podocyte apoptosis"}
{"concept_id": "C4233467", "aliases": [], "types": ["T043"], "canonical_name": "activation of glomerular visceral epithelial cell apoptotic process"}
{"concept_id": "C4233468", "aliases": [], "types": ["T043"], "canonical_name": "activation of glomerular visceral epithelial cell apoptosis"}
{"concept_id": "C4233469", "aliases": [], "types": ["T043"], "canonical_name": "activation of glomerular podocyte apoptotic process"}
{"concept_id": "C4233470", "aliases": [], "types": ["T043"], "canonical_name": "activation of glomerular podocyte apoptosis"}
{"concept_id": "C4233472", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glomerular visceral epithelial cell apoptosis"}
{"concept_id": "C4233473", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glomerular podocyte apoptosis"}
{"concept_id": "C4233474", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of podocyte apoptotic process"}
{"concept_id": "C4233475", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of podocyte apoptosis"}
{"concept_id": "C4233476", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glomerular visceral epithelial cell apoptotic process"}
{"concept_id": "C4233477", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glomerular visceral epithelial cell apoptosis"}
{"concept_id": "C4233478", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glomerular podocyte apoptotic process"}
{"concept_id": "C4233479", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glomerular podocyte apoptosis"}
{"concept_id": "C4233480", "aliases": ["downregulation of podocyte apoptosis", "down-regulation of podocyte apoptosis"], "types": ["T043"], "canonical_name": "down regulation of podocyte apoptosis"}
{"concept_id": "C4233481", "aliases": ["downregulation of glomerular visceral epithelial cell apoptosis", "down-regulation of glomerular visceral epithelial cell apoptosis"], "types": ["T043"], "canonical_name": "down regulation of glomerular visceral epithelial cell apoptosis"}
{"concept_id": "C4233482", "aliases": ["down-regulation of glomerular podocyte apoptosis", "downregulation of glomerular podocyte apoptosis"], "types": ["T043"], "canonical_name": "down regulation of glomerular podocyte apoptosis"}
{"concept_id": "C4233483", "aliases": [], "types": ["T043"], "canonical_name": "regulation of podocyte apoptosis"}
{"concept_id": "C4233484", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glomerular visceral epithelial cell apoptosis"}
{"concept_id": "C4233485", "aliases": [], "types": ["T043"], "canonical_name": "activation of glycine secretion, neurotransmission"}
{"concept_id": "C4233486", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glycine secretion, neurotransmission"}
{"concept_id": "C4233491", "aliases": ["upregulation of membrane associated actin binding", "up-regulation of membrane associated actin binding"], "types": ["T044"], "canonical_name": "up regulation of membrane associated actin binding"}
{"concept_id": "C4233492", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of membrane associated actin binding"}
{"concept_id": "C4233493", "aliases": [], "types": ["T044"], "canonical_name": "activation of membrane associated actin binding"}
{"concept_id": "C4233494", "aliases": [], "types": ["T044"], "canonical_name": "activation of actin binding"}
{"concept_id": "C4233495", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of membrane associated actin binding"}
{"concept_id": "C4233496", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of membrane associated actin binding"}
{"concept_id": "C4233497", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of actin binding"}
{"concept_id": "C4233498", "aliases": ["downregulation of membrane associated actin binding", "down-regulation of membrane associated actin binding"], "types": ["T044"], "canonical_name": "down regulation of membrane associated actin binding"}
{"concept_id": "C4233499", "aliases": [], "types": ["T044"], "canonical_name": "regulation of membrane associated actin binding"}
{"concept_id": "C4233500", "aliases": [], "types": ["T043"], "canonical_name": "fat cell apoptosis"}
{"concept_id": "C4233501", "aliases": [], "types": ["T043"], "canonical_name": "adipose cell apoptosis"}
{"concept_id": "C4233502", "aliases": [], "types": ["T043"], "canonical_name": "adipocyte apoptosis"}
{"concept_id": "C4233503", "aliases": [], "types": ["T044"], "canonical_name": "activation of RAGE activity"}
{"concept_id": "C4233504", "aliases": [], "types": ["T044"], "canonical_name": "activation of AGE receptor activity"}
{"concept_id": "C4233505", "aliases": [], "types": ["T044"], "canonical_name": "activation of advanced glycation end-product receptor activity"}
{"concept_id": "C4233506", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RAGE activity"}
{"concept_id": "C4233507", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of AGE receptor activity"}
{"concept_id": "C4233508", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of advanced glycation end-product receptor activity"}
{"concept_id": "C4233509", "aliases": ["5-hydroxytryptamine receptor complex location", "5HT receptor complex", "5-HT receptor complex", "5HT receptor complex location", "5-hydroxytryptamine receptor complex", "serotonin receptor complex", "serotonin receptor complex location", "5-HT receptor complex location"], "types": ["T026"], "canonical_name": "serotonin receptor complex", "definition": "A protein complex that is capable of serotonin receptor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]"}
{"concept_id": "C4233510", "aliases": ["up-regulation of fibrosis during inflammatory response", "upregulation of fibrosis during inflammatory response"], "types": ["T039"], "canonical_name": "up regulation of fibrosis during inflammatory response"}
{"concept_id": "C4233511", "aliases": ["up-regulation of connective tissue replacement during inflammatory response", "upregulation of connective tissue replacement during inflammatory response"], "types": ["T039"], "canonical_name": "up regulation of connective tissue replacement during inflammatory response"}
{"concept_id": "C4233512", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of fibrosis during inflammatory response"}
{"concept_id": "C4233513", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of connective tissue replacement during inflammatory response"}
{"concept_id": "C4233514", "aliases": [], "types": ["T039"], "canonical_name": "activation of fibrosis during inflammatory response"}
{"concept_id": "C4233515", "aliases": [], "types": ["T039"], "canonical_name": "activation of connective tissue replacement involved in inflammatory response wound healing"}
{"concept_id": "C4233516", "aliases": [], "types": ["T039"], "canonical_name": "activation of connective tissue replacement during inflammatory response"}
{"concept_id": "C4233517", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of fibrosis during inflammatory response"}
{"concept_id": "C4233518", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of connective tissue replacement during inflammatory response"}
{"concept_id": "C4233519", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of fibrosis during inflammatory response"}
{"concept_id": "C4233520", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of connective tissue replacement involved in inflammatory response wound healing"}
{"concept_id": "C4233521", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of connective tissue replacement during inflammatory response"}
{"concept_id": "C4233522", "aliases": ["down-regulation of fibrosis during inflammatory response", "downregulation of fibrosis during inflammatory response"], "types": ["T039"], "canonical_name": "down regulation of fibrosis during inflammatory response"}
{"concept_id": "C4233523", "aliases": ["down-regulation of connective tissue replacement during inflammatory response", "downregulation of connective tissue replacement during inflammatory response"], "types": ["T039"], "canonical_name": "down regulation of connective tissue replacement during inflammatory response"}
{"concept_id": "C4233524", "aliases": [], "types": ["T039"], "canonical_name": "regulation of fibrosis during inflammatory response"}
{"concept_id": "C4233525", "aliases": [], "types": ["T039"], "canonical_name": "regulation of connective tissue replacement during inflammatory response"}
{"concept_id": "C4233526", "aliases": ["up-regulation of RNA polymerase II transcription termination factor activity", "upregulation of RNA polymerase II transcription termination factor activity"], "types": ["T045"], "canonical_name": "up regulation of RNA polymerase II transcription termination factor activity"}
{"concept_id": "C4233527", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of RNA polymerase II transcription termination factor activity"}
{"concept_id": "C4233528", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription termination from RNA polymerase II promoter"}
{"concept_id": "C4233529", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription termination from Pol II promoter"}
{"concept_id": "C4233530", "aliases": ["activation of termination of RNA polymerase II transcription"], "types": ["T045"], "canonical_name": "activation of RNA polymerase II transcription termination"}
{"concept_id": "C4233531", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA polymerase II transcription termination factor activity"}
{"concept_id": "C4233532", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA 3'-end formation by RNA polymerase II"}
{"concept_id": "C4233533", "aliases": [], "types": ["T045"], "canonical_name": "regulation of RNA polymerase II transcription termination factor activity"}
{"concept_id": "C4233534", "aliases": ["upregulation of heat shock protein activity", "up-regulation of heat shock protein activity"], "types": ["T044"], "canonical_name": "up regulation of heat shock protein activity"}
{"concept_id": "C4233535", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heat shock protein activity"}
{"concept_id": "C4233536", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein refolding"}
{"concept_id": "C4233537", "aliases": [], "types": ["T044"], "canonical_name": "activation of heat shock protein activity"}
{"concept_id": "C4233538", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein uptake"}
{"concept_id": "C4233539", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein import"}
{"concept_id": "C4233540", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein uptake"}
{"concept_id": "C4233541", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein import"}
{"concept_id": "C4233542", "aliases": ["upregulation of mRNA positioning, intracellular", "up-regulation of intracellular mRNA positioning", "upregulation of intracellular mRNA positioning", "up-regulation of mRNA positioning, intracellular", "up regulation of mRNA positioning, intracellular"], "types": ["T039"], "canonical_name": "up regulation of intracellular mRNA positioning"}
{"concept_id": "C4233543", "aliases": ["positive regulation of mRNA positioning, intracellular"], "types": ["T043"], "canonical_name": "positive regulation of intracellular mRNA positioning"}
{"concept_id": "C4233544", "aliases": ["activation of mRNA positioning, intracellular"], "types": ["T043"], "canonical_name": "activation of intracellular mRNA positioning"}
{"concept_id": "C4233545", "aliases": ["activation of intracellular mRNA localization", "activation of mRNA localization, intracellular"], "types": ["T043"], "canonical_name": "activation of intracellular mRNA localisation"}
{"concept_id": "C4233546", "aliases": [], "types": ["T043"], "canonical_name": "activation of establishment and maintenance of intracellular RNA localization"}
{"concept_id": "C4233547", "aliases": ["negative regulation of mRNA positioning, intracellular"], "types": ["T039"], "canonical_name": "negative regulation of intracellular mRNA positioning"}
{"concept_id": "C4233548", "aliases": ["inhibition of mRNA positioning, intracellular"], "types": ["T044"], "canonical_name": "inhibition of intracellular mRNA positioning"}
{"concept_id": "C4233549", "aliases": ["inhibition of mRNA localization, intracellular", "inhibition of intracellular mRNA localization"], "types": ["T043"], "canonical_name": "inhibition of intracellular mRNA localisation"}
{"concept_id": "C4233550", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of establishment and maintenance of intracellular RNA localization"}
{"concept_id": "C4233551", "aliases": ["downregulation of intracellular mRNA positioning", "down regulation of mRNA positioning, intracellular", "down-regulation of mRNA positioning, intracellular", "downregulation of mRNA positioning, intracellular", "down-regulation of intracellular mRNA positioning"], "types": ["T043"], "canonical_name": "down regulation of intracellular mRNA positioning"}
{"concept_id": "C4233552", "aliases": ["regulation of mRNA positioning, intracellular"], "types": ["T044"], "canonical_name": "regulation of intracellular mRNA positioning"}
{"concept_id": "C4233553", "aliases": [], "types": ["T044"], "canonical_name": "activation of selenocysteine insertion sequence binding"}
{"concept_id": "C4233554", "aliases": [], "types": ["T044"], "canonical_name": "activation of SECIS binding"}
{"concept_id": "C4233555", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of selenocysteine insertion sequence binding"}
{"concept_id": "C4233556", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of SECIS binding"}
{"concept_id": "C4233557", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA binding"}
{"concept_id": "C4233558", "aliases": [], "types": ["T043"], "canonical_name": "activation of selenocysteine incorporation"}
{"concept_id": "C4233559", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of selenocysteine incorporation"}
{"concept_id": "C4233560", "aliases": [], "types": ["T043"], "canonical_name": "activation of chemotaxis to arachidonic acid"}
{"concept_id": "C4233561", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chemotaxis to arachidonic acid"}
{"concept_id": "C4233562", "aliases": [], "types": ["T044"], "canonical_name": "activation of free ubiquitin chain polymerization"}
{"concept_id": "C4233563", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of free ubiquitin chain polymerization"}
{"concept_id": "C4233564", "aliases": [], "types": ["T043"], "canonical_name": "fungal-type cell wall disassembly involved in mating"}
{"concept_id": "C4233565", "aliases": [], "types": ["T043"], "canonical_name": "fungal-type cell wall disassembly involved in cell fusion"}
{"concept_id": "C4233566", "aliases": [], "types": ["T043"], "canonical_name": "activation of glycolytic process through fructose-6-phosphate"}
{"concept_id": "C4233567", "aliases": [], "types": ["T044"], "canonical_name": "activation of glycolysis through fructose-6-phosphate"}
{"concept_id": "C4233568", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glycolytic process through fructose-6-phosphate"}
{"concept_id": "C4233569", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of glycolysis through fructose-6-phosphate"}
{"concept_id": "C4233570", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of mitotic telomere tethering at nuclear periphery"}
{"concept_id": "C4233571", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomeric loop disassembly"}
{"concept_id": "C4233572", "aliases": [], "types": ["T045"], "canonical_name": "activation of T loop disassembly"}
{"concept_id": "C4233573", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomeric loop disassembly"}
{"concept_id": "C4233574", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of T loop disassembly"}
{"concept_id": "C4233575", "aliases": ["upregulation of actin cross-linking activity", "up-regulation of actin cross-linking activity"], "types": ["T044"], "canonical_name": "up regulation of actin cross-linking activity"}
{"concept_id": "C4233576", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of actin cross-linking activity"}
{"concept_id": "C4233577", "aliases": [], "types": ["T044"], "canonical_name": "activation of F-actin binding"}
{"concept_id": "C4233578", "aliases": [], "types": ["T044"], "canonical_name": "activation of actin filament binding"}
{"concept_id": "C4233579", "aliases": [], "types": ["T044"], "canonical_name": "activation of actin cross-linking activity"}
{"concept_id": "C4233580", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of actin cross-linking activity"}
{"concept_id": "C4233581", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of F-actin binding"}
{"concept_id": "C4233582", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of actin filament binding"}
{"concept_id": "C4233583", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of actin cross-linking activity"}
{"concept_id": "C4233584", "aliases": ["down-regulation of actin cross-linking activity", "downregulation of actin cross-linking activity"], "types": ["T044"], "canonical_name": "down regulation of actin cross-linking activity"}
{"concept_id": "C4233585", "aliases": [], "types": ["T044"], "canonical_name": "regulation of actin cross-linking activity"}
{"concept_id": "C4233586", "aliases": ["up-regulation of microtubule/chromatin interaction", "upregulation of microtubule/chromatin interaction"], "types": ["T044"], "canonical_name": "up regulation of microtubule/chromatin interaction"}
{"concept_id": "C4233587", "aliases": ["upregulation of microtubule severing activity", "up-regulation of microtubule severing activity"], "types": ["T044"], "canonical_name": "up regulation of microtubule severing activity"}
{"concept_id": "C4233588", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of microtubule/chromatin interaction"}
{"concept_id": "C4233589", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of microtubule severing activity"}
{"concept_id": "C4233590", "aliases": [], "types": ["T044"], "canonical_name": "activation of microtubule/chromatin interaction"}
{"concept_id": "C4233591", "aliases": [], "types": ["T044"], "canonical_name": "activation of microtubule severing activity"}
{"concept_id": "C4233592", "aliases": [], "types": ["T044"], "canonical_name": "activation of microtubule binding"}
{"concept_id": "C4233593", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of microtubule/chromatin interaction"}
{"concept_id": "C4233594", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of microtubule severing activity"}
{"concept_id": "C4233595", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of microtubule/chromatin interaction"}
{"concept_id": "C4233596", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of microtubule severing activity"}
{"concept_id": "C4233597", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of microtubule binding"}
{"concept_id": "C4233598", "aliases": ["downregulation of microtubule/chromatin interaction", "down-regulation of microtubule/chromatin interaction"], "types": ["T044"], "canonical_name": "down regulation of microtubule/chromatin interaction"}
{"concept_id": "C4233599", "aliases": ["down-regulation of microtubule severing activity", "downregulation of microtubule severing activity"], "types": ["T044"], "canonical_name": "down regulation of microtubule severing activity"}
{"concept_id": "C4233600", "aliases": [], "types": ["T044"], "canonical_name": "regulation of microtubule/chromatin interaction"}
{"concept_id": "C4233601", "aliases": [], "types": ["T044"], "canonical_name": "regulation of microtubule severing activity"}
{"concept_id": "C4233602", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA amplification"}
{"concept_id": "C4233603", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA amplification"}
{"concept_id": "C4233604", "aliases": ["up-regulation of myofibroblast cell apoptosis", "upregulation of myofibroblast cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of myofibroblast cell apoptosis"}
{"concept_id": "C4233605", "aliases": ["up-regulation of MFB apoptosis", "upregulation of MFB apoptosis"], "types": ["T043"], "canonical_name": "up regulation of MFB apoptosis"}
{"concept_id": "C4233606", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of myofibroblast cell apoptosis"}
{"concept_id": "C4233607", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of MFB apoptosis"}
{"concept_id": "C4233608", "aliases": [], "types": ["T043"], "canonical_name": "activation of myofibroblast cell apoptotic process"}
{"concept_id": "C4233609", "aliases": [], "types": ["T043"], "canonical_name": "activation of myofibroblast cell apoptosis"}
{"concept_id": "C4233610", "aliases": [], "types": ["T043"], "canonical_name": "activation of MFB apoptotic process"}
{"concept_id": "C4233611", "aliases": [], "types": ["T043"], "canonical_name": "activation of MFB apoptosis"}
{"concept_id": "C4233612", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myofibroblast cell apoptosis"}
{"concept_id": "C4233613", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of MFB apoptosis"}
{"concept_id": "C4233614", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myofibroblast cell apoptotic process"}
{"concept_id": "C4233615", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myofibroblast cell apoptosis"}
{"concept_id": "C4233616", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of MFB apoptotic process"}
{"concept_id": "C4233617", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of MFB apoptosis"}
{"concept_id": "C4233618", "aliases": ["downregulation of myofibroblast cell apoptosis", "down-regulation of myofibroblast cell apoptosis"], "types": ["T043"], "canonical_name": "down regulation of myofibroblast cell apoptosis"}
{"concept_id": "C4233619", "aliases": ["downregulation of MFB apoptosis", "down-regulation of MFB apoptosis"], "types": ["T043"], "canonical_name": "down regulation of MFB apoptosis"}
{"concept_id": "C4233620", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myofibroblast cell apoptosis"}
{"concept_id": "C4233621", "aliases": [], "types": ["T043"], "canonical_name": "regulation of MFB apoptosis"}
{"concept_id": "C4233622", "aliases": [], "types": ["T043"], "canonical_name": "myofibroblast cell apoptosis"}
{"concept_id": "C4233623", "aliases": [], "types": ["T043"], "canonical_name": "MFB apoptosis"}
{"concept_id": "C4233624", "aliases": [], "types": ["T044"], "canonical_name": "activation of TORC2 signaling"}
{"concept_id": "C4233625", "aliases": [], "types": ["T044"], "canonical_name": "activation of TORC2 signal transduction"}
{"concept_id": "C4233626", "aliases": ["upregulation of meiotic DNA replication initiation", "up-regulation of meiotic DNA replication initiation"], "types": ["T043"], "canonical_name": "up regulation of meiotic DNA replication initiation"}
{"concept_id": "C4233627", "aliases": ["upregulation of initiation of premeiotic DNA synthesis", "up-regulation of initiation of premeiotic DNA synthesis"], "types": ["T045"], "canonical_name": "up regulation of initiation of premeiotic DNA synthesis"}
{"concept_id": "C4233628", "aliases": ["up-regulation of initiation of meiotic DNA synthesis", "upregulation of initiation of meiotic DNA synthesis"], "types": ["T043"], "canonical_name": "up regulation of initiation of meiotic DNA synthesis"}
{"concept_id": "C4233629", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of meiotic DNA replication initiation"}
{"concept_id": "C4233630", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of initiation of premeiotic DNA synthesis"}
{"concept_id": "C4233631", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of initiation of meiotic DNA synthesis"}
{"concept_id": "C4233632", "aliases": ["activation of premeiotic DNA replication initiation"], "types": ["T045"], "canonical_name": "activation of initiation of premeiotic DNA replication"}
{"concept_id": "C4233633", "aliases": [], "types": ["T043"], "canonical_name": "activation of meiotic DNA replication initiation"}
{"concept_id": "C4233634", "aliases": [], "types": ["T043"], "canonical_name": "activation of initiation of premeiotic DNA synthesis"}
{"concept_id": "C4233635", "aliases": [], "types": ["T043"], "canonical_name": "activation of initiation of meiotic DNA synthesis"}
{"concept_id": "C4233636", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of meiotic DNA replication initiation"}
{"concept_id": "C4233637", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of initiation of premeiotic DNA synthesis"}
{"concept_id": "C4233638", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of initiation of meiotic DNA synthesis"}
{"concept_id": "C4233639", "aliases": ["inhibition of premeiotic DNA replication initiation"], "types": ["T045"], "canonical_name": "inhibition of initiation of premeiotic DNA replication"}
{"concept_id": "C4233640", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of meiotic DNA replication initiation"}
{"concept_id": "C4233641", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of initiation of premeiotic DNA synthesis"}
{"concept_id": "C4233642", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of initiation of meiotic DNA synthesis"}
{"concept_id": "C4233643", "aliases": ["downregulation of meiotic DNA replication initiation", "down-regulation of meiotic DNA replication initiation"], "types": ["T045"], "canonical_name": "down regulation of meiotic DNA replication initiation"}
{"concept_id": "C4233644", "aliases": ["down-regulation of initiation of premeiotic DNA synthesis", "downregulation of initiation of premeiotic DNA synthesis"], "types": ["T045"], "canonical_name": "down regulation of initiation of premeiotic DNA synthesis"}
{"concept_id": "C4233645", "aliases": ["down-regulation of initiation of meiotic DNA synthesis", "downregulation of initiation of meiotic DNA synthesis"], "types": ["T045"], "canonical_name": "down regulation of initiation of meiotic DNA synthesis"}
{"concept_id": "C4233646", "aliases": [], "types": ["T045"], "canonical_name": "regulation of meiotic DNA replication initiation"}
{"concept_id": "C4233647", "aliases": [], "types": ["T045"], "canonical_name": "regulation of initiation of premeiotic DNA synthesis"}
{"concept_id": "C4233648", "aliases": [], "types": ["T045"], "canonical_name": "regulation of initiation of meiotic DNA synthesis"}
{"concept_id": "C4233649", "aliases": ["microtubule plus-end of non-spindle-associated astral microtubule"], "types": ["T026"], "canonical_name": "microtubule plus end of non-spindle-associated astral microtubule"}
{"concept_id": "C4233650", "aliases": [], "types": ["T026"], "canonical_name": "growing microtubule plus end of non-spindle-associated astral microtubule"}
{"concept_id": "C4233651", "aliases": ["activation of protein localization to basolateral plasma membrane", "activation of protein localization in basolateral plasma membrane", "activation of protein localisation to basolateral plasma membrane"], "types": ["T043"], "canonical_name": "activation of protein localisation in basolateral plasma membrane"}
{"concept_id": "C4233652", "aliases": ["inhibition of protein localization to basolateral plasma membrane"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to basolateral plasma membrane"}
{"concept_id": "C4233653", "aliases": ["inhibition of protein localization in basolateral plasma membrane"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in basolateral plasma membrane"}
{"concept_id": "C4233654", "aliases": ["activation of telomere maintenance in response to DNA damage"], "types": ["T045"], "canonical_name": "activation of DNA damage response, telomere maintenance"}
{"concept_id": "C4233655", "aliases": ["inhibition of telomere maintenance in response to DNA damage"], "types": ["T045"], "canonical_name": "inhibition of DNA damage response, telomere maintenance"}
{"concept_id": "C4233656", "aliases": [], "types": ["T043"], "canonical_name": "activation of lipophagy"}
{"concept_id": "C4233657", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lipophagy"}
{"concept_id": "C4233660", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to actomyosin contractile ring during mitotic cytokinesis"}
{"concept_id": "C4233661", "aliases": [], "types": ["T043"], "canonical_name": "heterochromatin formation involved in chromatin silencing at pericentric region"}
{"concept_id": "C4233662", "aliases": [], "types": ["T043"], "canonical_name": "heterochromatin assembly involved in chromatin silencing at pericentric region"}
{"concept_id": "C4233663", "aliases": [], "types": ["T043"], "canonical_name": "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region"}
{"concept_id": "C4233664", "aliases": [], "types": ["T043"], "canonical_name": "activation of substance P secretion, neurotransmission"}
{"concept_id": "C4233665", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of substance P secretion, neurotransmission"}
{"concept_id": "C4233666", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter, global"}
{"concept_id": "C4233667", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mtUPR by negative regulation of global transcription from Pol II promoter"}
{"concept_id": "C4233668", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mtUPR by negative regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C4233669", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mtUPR by inhibition of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233670", "aliases": ["negative regulation of mtUPR by down-regulation of global transcription from RNA polymerase II promoter", "negative regulation of mtUPR by downregulation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of mtUPR by down regulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233671", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter, global"}
{"concept_id": "C4233672", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial unfolded protein response by negative regulation of global transcription from Pol II promoter"}
{"concept_id": "C4233673", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial unfolded protein response by negative regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C4233674", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial unfolded protein response by inhibition of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233675", "aliases": ["negative regulation of mitochondrial unfolded protein response by downregulation of global transcription from RNA polymerase II promoter", "negative regulation of mitochondrial unfolded protein response by down-regulation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial unfolded protein response by down regulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233676", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter, global"}
{"concept_id": "C4233677", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by negative regulation of global transcription from Pol II promoter"}
{"concept_id": "C4233678", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C4233679", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by inhibition of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233680", "aliases": ["regulation of ROS metabolic process by downregulation of global transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by down-regulation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by down regulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233681", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter, global"}
{"concept_id": "C4233682", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by negative regulation of global transcription from Pol II promoter"}
{"concept_id": "C4233683", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by negative regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C4233684", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by inhibition of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233685", "aliases": ["regulation of reactive oxygen species metabolism by downregulation of global transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by down-regulation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by down regulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233686", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter, global"}
{"concept_id": "C4233687", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by negative regulation of global transcription from Pol II promoter"}
{"concept_id": "C4233688", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C4233689", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by inhibition of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233690", "aliases": ["regulation of reactive oxygen species metabolic process by down-regulation of global transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolic process by downregulation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by down regulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233691", "aliases": ["regulation of ROS metabolic process by upregulation of global transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by up-regulation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by up regulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233692", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by stimulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233693", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter, global"}
{"concept_id": "C4233694", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by positive regulation of global transcription from Pol II promoter"}
{"concept_id": "C4233695", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C4233696", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ROS metabolic process by activation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233697", "aliases": ["regulation of reactive oxygen species metabolism by up-regulation of global transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by upregulation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by up regulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233698", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by stimulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233699", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter, global"}
{"concept_id": "C4233700", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by positive regulation of global transcription from Pol II promoter"}
{"concept_id": "C4233701", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by positive regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C4233702", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolism by activation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233703", "aliases": ["regulation of reactive oxygen species metabolic process by up-regulation of global transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolic process by upregulation of global transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by up regulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233704", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by stimulation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233705", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter, global"}
{"concept_id": "C4233706", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by positive regulation of global transcription from Pol II promoter"}
{"concept_id": "C4233707", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter"}
{"concept_id": "C4233708", "aliases": [], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by activation of global transcription from RNA polymerase II promoter"}
{"concept_id": "C4233709", "aliases": [], "types": ["T043"], "canonical_name": "activation of intestinal absorption"}
{"concept_id": "C4233710", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intestinal absorption"}
{"concept_id": "C4233719", "aliases": ["up-regulation of endothelin-3 secretion", "upregulation of endothelin-3 secretion"], "types": ["T043"], "canonical_name": "up regulation of endothelin-3 secretion"}
{"concept_id": "C4233720", "aliases": ["up-regulation of endothelin-2 secretion", "upregulation of endothelin-2 secretion"], "types": ["T043"], "canonical_name": "up regulation of endothelin-2 secretion"}
{"concept_id": "C4233721", "aliases": ["upregulation of endothelin-1 secretion", "up-regulation of endothelin-1 secretion"], "types": ["T043"], "canonical_name": "up regulation of endothelin-1 secretion"}
{"concept_id": "C4233722", "aliases": ["upregulation of EDN3 secretion", "up-regulation of EDN3 secretion"], "types": ["T043"], "canonical_name": "up regulation of EDN3 secretion"}
{"concept_id": "C4233723", "aliases": ["upregulation of EDN2 secretion", "up-regulation of EDN2 secretion"], "types": ["T043"], "canonical_name": "up regulation of EDN2 secretion"}
{"concept_id": "C4233724", "aliases": ["up-regulation of EDN1 secretion", "upregulation of EDN1 secretion"], "types": ["T043"], "canonical_name": "up regulation of EDN1 secretion"}
{"concept_id": "C4233725", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endothelin-3 secretion"}
{"concept_id": "C4233726", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endothelin-2 secretion"}
{"concept_id": "C4233727", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endothelin-1 secretion"}
{"concept_id": "C4233728", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of EDN3 secretion"}
{"concept_id": "C4233729", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of EDN2 secretion"}
{"concept_id": "C4233730", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of EDN1 secretion"}
{"concept_id": "C4233731", "aliases": [], "types": ["T043"], "canonical_name": "activation of endothelin-3 secretion"}
{"concept_id": "C4233732", "aliases": [], "types": ["T043"], "canonical_name": "activation of endothelin-1 secretion"}
{"concept_id": "C4233733", "aliases": [], "types": ["T043"], "canonical_name": "activation of endothelin secretion"}
{"concept_id": "C4233734", "aliases": [], "types": ["T043"], "canonical_name": "activation of EDN3 secretion"}
{"concept_id": "C4233735", "aliases": [], "types": ["T043"], "canonical_name": "activation of EDN2 secretion"}
{"concept_id": "C4233736", "aliases": [], "types": ["T043"], "canonical_name": "activation of EDN1 secretion"}
{"concept_id": "C4233737", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endothelin-3 secretion"}
{"concept_id": "C4233738", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endothelin-2 secretion"}
{"concept_id": "C4233739", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endothelin-1 secretion"}
{"concept_id": "C4233740", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of EDN3 secretion"}
{"concept_id": "C4233741", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of EDN2 secretion"}
{"concept_id": "C4233742", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of EDN1 secretion"}
{"concept_id": "C4233743", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelin-3 secretion"}
{"concept_id": "C4233744", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelin-2 secretion"}
{"concept_id": "C4233745", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelin-1 secretion"}
{"concept_id": "C4233746", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endothelin secretion"}
{"concept_id": "C4233747", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of EDN3 secretion"}
{"concept_id": "C4233748", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of EDN2 secretion"}
{"concept_id": "C4233749", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of EDN1 secretion"}
{"concept_id": "C4233750", "aliases": ["down-regulation of endothelin-3 secretion", "downregulation of endothelin-3 secretion"], "types": ["T043"], "canonical_name": "down regulation of endothelin-3 secretion"}
{"concept_id": "C4233751", "aliases": ["downregulation of endothelin-2 secretion", "down-regulation of endothelin-2 secretion"], "types": ["T043"], "canonical_name": "down regulation of endothelin-2 secretion"}
{"concept_id": "C4233752", "aliases": ["down-regulation of endothelin-1 secretion", "downregulation of endothelin-1 secretion"], "types": ["T043"], "canonical_name": "down regulation of endothelin-1 secretion"}
{"concept_id": "C4233753", "aliases": ["downregulation of EDN3 secretion", "down-regulation of EDN3 secretion"], "types": ["T043"], "canonical_name": "down regulation of EDN3 secretion"}
{"concept_id": "C4233754", "aliases": ["downregulation of EDN2 secretion", "down-regulation of EDN2 secretion"], "types": ["T043"], "canonical_name": "down regulation of EDN2 secretion"}
{"concept_id": "C4233755", "aliases": ["downregulation of EDN1 secretion", "down-regulation of EDN1 secretion"], "types": ["T043"], "canonical_name": "down regulation of EDN1 secretion"}
{"concept_id": "C4233756", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelin-3 secretion"}
{"concept_id": "C4233757", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelin-2 secretion"}
{"concept_id": "C4233758", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelin-1 secretion"}
{"concept_id": "C4233759", "aliases": [], "types": ["T043"], "canonical_name": "regulation of EDN3 secretion"}
{"concept_id": "C4233760", "aliases": [], "types": ["T043"], "canonical_name": "regulation of EDN2 secretion"}
{"concept_id": "C4233761", "aliases": [], "types": ["T043"], "canonical_name": "regulation of EDN1 secretion"}
{"concept_id": "C4233778", "aliases": ["upregulation of matrix metalloproteinase secretion", "up-regulation of matrix metalloproteinase secretion"], "types": ["T043"], "canonical_name": "up regulation of matrix metalloproteinase secretion"}
{"concept_id": "C4233779", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of matrix metalloproteinase secretion"}
{"concept_id": "C4233780", "aliases": [], "types": ["T043"], "canonical_name": "activation of MMP secretion"}
{"concept_id": "C4233781", "aliases": [], "types": ["T043"], "canonical_name": "activation of matrix metalloproteinase secretion"}
{"concept_id": "C4233782", "aliases": [], "types": ["T043"], "canonical_name": "activation of matrix metallopeptidase secretion"}
{"concept_id": "C4233783", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of matrix metalloproteinase secretion"}
{"concept_id": "C4233784", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of MMP secretion"}
{"concept_id": "C4233785", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of matrix metalloproteinase secretion"}
{"concept_id": "C4233786", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of matrix metallopeptidase secretion"}
{"concept_id": "C4233787", "aliases": ["downregulation of matrix metalloproteinase secretion", "down-regulation of matrix metalloproteinase secretion"], "types": ["T043"], "canonical_name": "down regulation of matrix metalloproteinase secretion"}
{"concept_id": "C4233788", "aliases": [], "types": ["T043"], "canonical_name": "regulation of matrix metalloproteinase secretion"}
{"concept_id": "C4233789", "aliases": [], "types": ["T043"], "canonical_name": "activation of substance P secretion"}
{"concept_id": "C4233790", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of substance P secretion"}
{"concept_id": "C4233791", "aliases": ["upregulation of generation of action potential", "up-regulation of generation of action potential"], "types": ["T043"], "canonical_name": "up regulation of generation of action potential"}
{"concept_id": "C4233792", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of generation of action potential"}
{"concept_id": "C4233793", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuronal action potential"}
{"concept_id": "C4233794", "aliases": [], "types": ["T043"], "canonical_name": "activation of generation of action potential"}
{"concept_id": "C4233795", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of generation of action potential"}
{"concept_id": "C4233796", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuronal action potential"}
{"concept_id": "C4233797", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of generation of action potential"}
{"concept_id": "C4233798", "aliases": ["downregulation of generation of action potential", "down-regulation of generation of action potential"], "types": ["T043"], "canonical_name": "down regulation of generation of action potential"}
{"concept_id": "C4233910", "aliases": ["up-regulation of gastric H+/K+ ATPase", "upregulation of gastric H+/K+ ATPase"], "types": ["T044"], "canonical_name": "up regulation of gastric H+/K+ ATPase"}
{"concept_id": "C4233911", "aliases": ["upregulation of gastric H(+)/K(+) ATPase activity", "up-regulation of gastric H(+)/K(+) ATPase activity"], "types": ["T044"], "canonical_name": "up regulation of gastric H(+)/K(+) ATPase activity"}
{"concept_id": "C4233912", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of gastric H+/K+ ATPase"}
{"concept_id": "C4233913", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of gastric H(+)/K(+) ATPase activity"}
{"concept_id": "C4233914", "aliases": ["activation of hydrogen:potassium exchanging ATPase activity", "activation of hydrogen:potassium-exchanging ATPase activity"], "types": ["T044"], "canonical_name": "activation of hydrogen/potassium-exchanging ATPase activity"}
{"concept_id": "C4233915", "aliases": ["activation of H+/K+-ATPase activity", "activation of H+-K+-ATPase activity", "activation of H(+)/K(+)-ATPase activity", "activation of H,K-ATPase activity"], "types": ["T044"], "canonical_name": "activation of (K+ + H+)-ATPase activity"}
{"concept_id": "C4233916", "aliases": ["activation of H+/K+-exchanging ATPase activity"], "types": ["T044"], "canonical_name": "activation of H(+)/K(+)-exchanging ATPase activity"}
{"concept_id": "C4233917", "aliases": [], "types": ["T044"], "canonical_name": "activation of gastric H+/K+ ATPase"}
{"concept_id": "C4233918", "aliases": [], "types": ["T044"], "canonical_name": "activation of gastric H(+)/K(+) ATPase activity"}
{"concept_id": "C4233919", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATP phosphohydrolase (H+/K+-exchanging)"}
{"concept_id": "C4233920", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of gastric H+/K+ ATPase"}
{"concept_id": "C4233921", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of gastric H(+)/K(+) ATPase activity"}
{"concept_id": "C4233922", "aliases": ["inhibition of hydrogen:potassium exchanging ATPase activity", "inhibition of hydrogen:potassium-exchanging ATPase activity"], "types": ["T044"], "canonical_name": "inhibition of hydrogen/potassium-exchanging ATPase activity"}
{"concept_id": "C4233923", "aliases": ["inhibition of H(+)/K(+)-ATPase activity", "inhibition of H+/K+-ATPase activity", "inhibition of H+-K+-ATPase activity", "inhibition of H,K-ATPase activity"], "types": ["T044"], "canonical_name": "inhibition of (K+ + H+)-ATPase activity"}
{"concept_id": "C4233924", "aliases": ["inhibition of H+/K+-exchanging ATPase activity"], "types": ["T044"], "canonical_name": "inhibition of H(+)/K(+)-exchanging ATPase activity"}
{"concept_id": "C4233925", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of gastric H+/K+ ATPase"}
{"concept_id": "C4233926", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of gastric H(+)/K(+) ATPase activity"}
{"concept_id": "C4233927", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATP phosphohydrolase (H+/K+-exchanging)"}
{"concept_id": "C4233928", "aliases": ["downregulation of gastric H+/K+ ATPase", "down-regulation of gastric H+/K+ ATPase"], "types": ["T044"], "canonical_name": "down regulation of gastric H+/K+ ATPase"}
{"concept_id": "C4233929", "aliases": ["down-regulation of gastric H(+)/K(+) ATPase activity", "downregulation of gastric H(+)/K(+) ATPase activity"], "types": ["T044"], "canonical_name": "down regulation of gastric H(+)/K(+) ATPase activity"}
{"concept_id": "C4233930", "aliases": [], "types": ["T044"], "canonical_name": "regulation of proton pump activity"}
{"concept_id": "C4233931", "aliases": [], "types": ["T044"], "canonical_name": "regulation of gastric H+/K+ ATPase"}
{"concept_id": "C4233932", "aliases": [], "types": ["T044"], "canonical_name": "regulation of gastric H(+)/K(+) ATPase activity"}
{"concept_id": "C4233933", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartate secretion"}
{"concept_id": "C4233934", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartate secretion"}
{"concept_id": "C4233935", "aliases": [], "types": ["T043"], "canonical_name": "activation of establishment of Sertoli cell barrier"}
{"concept_id": "C4233936", "aliases": [], "types": ["T043"], "canonical_name": "activation of establishment of SCB"}
{"concept_id": "C4233937", "aliases": [], "types": ["T043"], "canonical_name": "activation of establishment of BTB"}
{"concept_id": "C4233938", "aliases": [], "types": ["T043"], "canonical_name": "activation of establishment of blood-testis barrier"}
{"concept_id": "C4233939", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of establishment of Sertoli cell barrier"}
{"concept_id": "C4233940", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of establishment of SCB"}
{"concept_id": "C4233941", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of establishment of BTB"}
{"concept_id": "C4233942", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of establishment of blood-testis barrier"}
{"concept_id": "C4233943", "aliases": ["upregulation of thyroid follicular cell proliferation", "up-regulation of thyroid follicular cell proliferation"], "types": ["T043"], "canonical_name": "up regulation of thyroid follicular cell proliferation"}
{"concept_id": "C4233944", "aliases": ["upregulation of Hurthle cell proliferation", "up-regulation of Hurthle cell proliferation"], "types": ["T043"], "canonical_name": "up regulation of Hurthle cell proliferation"}
{"concept_id": "C4233945", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of thyroid follicular cell proliferation"}
{"concept_id": "C4233946", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Hurthle cell proliferation"}
{"concept_id": "C4233947", "aliases": [], "types": ["T043"], "canonical_name": "activation of thyroid gland epithelial cell proliferation"}
{"concept_id": "C4233948", "aliases": [], "types": ["T043"], "canonical_name": "activation of thyroid follicular cell proliferation"}
{"concept_id": "C4233949", "aliases": [], "types": ["T043"], "canonical_name": "activation of Hurthle cell proliferation"}
{"concept_id": "C4233950", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of thyroid follicular cell proliferation"}
{"concept_id": "C4233951", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Hurthle cell proliferation"}
{"concept_id": "C4233952", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of thyroid gland epithelial cell proliferation"}
{"concept_id": "C4233953", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of thyroid follicular cell proliferation"}
{"concept_id": "C4233954", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Hurthle cell proliferation"}
{"concept_id": "C4233955", "aliases": ["down-regulation of thyroid follicular cell proliferation", "downregulation of thyroid follicular cell proliferation"], "types": ["T043"], "canonical_name": "down regulation of thyroid follicular cell proliferation"}
{"concept_id": "C4233956", "aliases": ["down-regulation of Hurthle cell proliferation", "downregulation of Hurthle cell proliferation"], "types": ["T043"], "canonical_name": "down regulation of Hurthle cell proliferation"}
{"concept_id": "C4233957", "aliases": [], "types": ["T043"], "canonical_name": "regulation of thyroid follicular cell proliferation"}
{"concept_id": "C4233958", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Hurthle cell proliferation"}
{"concept_id": "C4233959", "aliases": [], "types": ["T043"], "canonical_name": "activation of ferrous iron import across plasma membrane"}
{"concept_id": "C4233960", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ferrous iron import across plasma membrane"}
{"concept_id": "C4233961", "aliases": [], "types": ["T044"], "canonical_name": "activation of transferrin receptor binding"}
{"concept_id": "C4233962", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of transferrin receptor binding"}
{"concept_id": "C4233963", "aliases": [], "types": ["T044"], "canonical_name": "activation of ferrous iron binding"}
{"concept_id": "C4233964", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ferrous iron binding"}
{"concept_id": "C4233965", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomeric circle formation"}
{"concept_id": "C4233966", "aliases": [], "types": ["T045"], "canonical_name": "activation of t-circle formation"}
{"concept_id": "C4233967", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomeric circle formation"}
{"concept_id": "C4233968", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of t-circle formation"}
{"concept_id": "C4233969", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tubulin deacetylation"}
{"concept_id": "C4233970", "aliases": [], "types": ["T043"], "canonical_name": "activation of transmembrane calcium transport"}
{"concept_id": "C4233971", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium ion transmembrane transport"}
{"concept_id": "C4233972", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium ion membrane transport"}
{"concept_id": "C4233973", "aliases": [], "types": ["T044"], "canonical_name": "activation of GTP binding"}
{"concept_id": "C4233974", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of GTP binding"}
{"concept_id": "C4233975", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomeric loop formation"}
{"concept_id": "C4233976", "aliases": [], "types": ["T045"], "canonical_name": "activation of t-loop formation"}
{"concept_id": "C4233977", "aliases": [], "types": ["T045"], "canonical_name": "activation of t-loop biosynthesis"}
{"concept_id": "C4233978", "aliases": ["inhibition of telomeric loop formation"], "types": ["T045"], "canonical_name": "inhibition of t-loop formation"}
{"concept_id": "C4233979", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of t-loop biosynthesis"}
{"concept_id": "C4233980", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of xenophagy"}
{"concept_id": "C4233981", "aliases": [], "types": ["T042"], "canonical_name": "activation of cardiac ventricle development"}
{"concept_id": "C4233982", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of cardiac ventricle development"}
{"concept_id": "C4233983", "aliases": ["up-regulation of secretory granule organization and biogenesis", "upregulation of secretory granule organization and biogenesis"], "types": ["T043"], "canonical_name": "up regulation of secretory granule organization and biogenesis"}
{"concept_id": "C4233984", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of secretory granule organization and biogenesis"}
{"concept_id": "C4233985", "aliases": [], "types": ["T043"], "canonical_name": "activation of secretory granule organization and biogenesis"}
{"concept_id": "C4233986", "aliases": ["activation of secretory granule organization"], "types": ["T043"], "canonical_name": "activation of secretory granule organisation"}
{"concept_id": "C4233987", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of secretory granule organization and biogenesis"}
{"concept_id": "C4233988", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of secretory granule organization and biogenesis"}
{"concept_id": "C4233989", "aliases": ["inhibition of secretory granule organization"], "types": ["T043"], "canonical_name": "inhibition of secretory granule organisation"}
{"concept_id": "C4233990", "aliases": ["down-regulation of secretory granule organization and biogenesis", "downregulation of secretory granule organization and biogenesis"], "types": ["T043"], "canonical_name": "down regulation of secretory granule organization and biogenesis"}
{"concept_id": "C4233991", "aliases": [], "types": ["T043"], "canonical_name": "regulation of secretory granule organization and biogenesis"}
{"concept_id": "C4233992", "aliases": [], "types": ["T044"], "canonical_name": "activation of nitric oxide metabolism"}
{"concept_id": "C4233993", "aliases": [], "types": ["T044"], "canonical_name": "activation of nitric oxide metabolic process"}
{"concept_id": "C4233994", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nitric oxide metabolism"}
{"concept_id": "C4233995", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of nitric oxide metabolic process"}
{"concept_id": "C4233996", "aliases": ["upregulation of NMJ stability", "up-regulation of NMJ stability"], "types": ["T043"], "canonical_name": "up regulation of NMJ stability"}
{"concept_id": "C4233997", "aliases": ["up-regulation of neuromuscular junction stability", "upregulation of neuromuscular junction stability"], "types": ["T043"], "canonical_name": "up regulation of neuromuscular junction stability"}
{"concept_id": "C4233998", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of NMJ stability"}
{"concept_id": "C4233999", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of neuromuscular junction stability"}
{"concept_id": "C4234000", "aliases": ["activation of neuromuscular junction stability"], "types": ["T042"], "canonical_name": "activation of NMJ stability"}
{"concept_id": "C4234001", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuromuscular junction organization"}
{"concept_id": "C4234002", "aliases": [], "types": ["T043"], "canonical_name": "activation of neuromuscular junction development"}
{"concept_id": "C4234003", "aliases": ["negative regulation of NMJ stability", "negative regulation of neuromuscular junction organization"], "types": ["T043"], "canonical_name": "negative regulation of neuromuscular junction development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development. [GO_REF:0000058, GOC:TermGenie, PMID:7722643]"}
{"concept_id": "C4234004", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of neuromuscular junction stability"}
{"concept_id": "C4234005", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of NMJ stability"}
{"concept_id": "C4234006", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuromuscular junction stability"}
{"concept_id": "C4234007", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuromuscular junction organization"}
{"concept_id": "C4234008", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuromuscular junction development"}
{"concept_id": "C4234009", "aliases": ["down-regulation of NMJ stability", "downregulation of NMJ stability"], "types": ["T043"], "canonical_name": "down regulation of NMJ stability"}
{"concept_id": "C4234010", "aliases": ["downregulation of neuromuscular junction stability", "down-regulation of neuromuscular junction stability"], "types": ["T042"], "canonical_name": "down regulation of neuromuscular junction stability"}
{"concept_id": "C4234011", "aliases": [], "types": ["T042"], "canonical_name": "regulation of NMJ stability"}
{"concept_id": "C4234012", "aliases": [], "types": ["T042"], "canonical_name": "regulation of neuromuscular junction stability"}
{"concept_id": "C4234013", "aliases": [], "types": ["T043"], "canonical_name": "activation of skeletal muscle nicotinic acetylcholine receptor clustering"}
{"concept_id": "C4234014", "aliases": [], "types": ["T043"], "canonical_name": "activation of skeletal muscle AChR clustering"}
{"concept_id": "C4234015", "aliases": [], "types": ["T043"], "canonical_name": "activation of skeletal muscle acetylcholine-gated channel clustering"}
{"concept_id": "C4234016", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of skeletal muscle nicotinic acetylcholine receptor clustering"}
{"concept_id": "C4234017", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of skeletal muscle AChR clustering"}
{"concept_id": "C4234018", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of skeletal muscle acetylcholine-gated channel clustering"}
{"concept_id": "C4234019", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of pasRNA transcription"}
{"concept_id": "C4234020", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of pasRNA transcription"}
{"concept_id": "C4234021", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of ncRNA transcription associated with protein coding gene TSS/TES"}
{"concept_id": "C4234022", "aliases": ["down-regulation of pasRNA transcription", "downregulation of pasRNA transcription"], "types": ["T045"], "canonical_name": "down regulation of pasRNA transcription"}
{"concept_id": "C4234023", "aliases": [], "types": ["T044"], "canonical_name": "mannose trimming involved in misfolded or incompletely synthesized glycoprotein catabolic process"}
{"concept_id": "C4234024", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming involved in gpERAD"}
{"concept_id": "C4234025", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming involved in glycoprotein ERAD pathway"}
{"concept_id": "C4234026", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming involved in glycoprotein ERAD"}
{"concept_id": "C4234027", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming involved in ER-associated glycoprotein degradation"}
{"concept_id": "C4234028", "aliases": [], "types": ["T044"], "canonical_name": "protein alpha-1,2-demannosylation in Golgi ribbon"}
{"concept_id": "C4234029", "aliases": [], "types": ["T044"], "canonical_name": "mannose trimming in Golgi"}
{"concept_id": "C4234030", "aliases": [], "types": ["T044"], "canonical_name": "mannose trimming in cis-Golgi"}
{"concept_id": "C4234031", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming in Golgi ribbon"}
{"concept_id": "C4234032", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming in Golgi complex"}
{"concept_id": "C4234033", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming in Golgi apparatus"}
{"concept_id": "C4234034", "aliases": [], "types": ["T044"], "canonical_name": "protein alpha-1,2-demannosylation in ER-derived quality control compartment"}
{"concept_id": "C4234035", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming in ERQC"}
{"concept_id": "C4234036", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming in ER-derived quality control compartment"}
{"concept_id": "C4234037", "aliases": ["glycoprotein mannose trimming in endoplasmic reticulum quality control compartment"], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming in ER quality control compartment"}
{"concept_id": "C4234038", "aliases": ["protein localisation to cytosolic proteasome complex involved in ERAD pathway", "protein localization to cytosolic proteasome complex involved in ER-associated degradation pathway", "protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation", "protein localisation to cytosolic proteasome complex involved in ER-associated degradation pathway", "protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation"], "types": ["T043"], "canonical_name": "protein localization to cytosolic proteasome complex involved in ERAD pathway", "definition": "Any protein localization to cytosolic proteasome complex that is involved in ERAD pathway. Following their retrotranslocation out of the endoplasmic reticulum, protein substrates must be shuttled to the cytosolic proteasome for degradation. [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303]"}
{"concept_id": "C4234039", "aliases": ["protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway"], "types": ["T043"], "canonical_name": "protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234040", "aliases": ["protein localization in cytosolic proteasome complex involved in ER-associated degradation pathway", "protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation", "protein localization in cytosolic proteasome complex involved in ERAD pathway", "protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation", "protein localisation in cytosolic proteasome complex involved in ERAD pathway"], "types": ["T043"], "canonical_name": "protein localisation in cytosolic proteasome complex involved in ER-associated degradation pathway"}
{"concept_id": "C4234041", "aliases": ["protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway"], "types": ["T043"], "canonical_name": "protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234042", "aliases": ["maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation", "maintenance of unfolded protein involved in ER-associated degradation pathway"], "types": ["T043"], "canonical_name": "maintenance of unfolded protein involved in ERAD pathway", "definition": "Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome. [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303]"}
{"concept_id": "C4234043", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234044", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of unfolded protein during ERAD"}
{"concept_id": "C4234045", "aliases": [], "types": ["T043"], "canonical_name": "holdase activity"}
{"concept_id": "C4234046", "aliases": [], "types": ["T043"], "canonical_name": "ERAD chaperone-like activity"}
{"concept_id": "C4234047", "aliases": [], "types": ["T043"], "canonical_name": "chaperone holdase activity"}
{"concept_id": "C4234048", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein localization to cell periphery"}
{"concept_id": "C4234049", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein localization to cell periphery"}
{"concept_id": "C4234050", "aliases": ["activation of protein localization to actin cortical patch"], "types": ["T039"], "canonical_name": "activation of protein localisation to actin cortical patch"}
{"concept_id": "C4234051", "aliases": ["inhibition of protein localization to actin cortical patch"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to actin cortical patch"}
{"concept_id": "C4234052", "aliases": [], "types": ["T039"], "canonical_name": "activation of chemokinesis"}
{"concept_id": "C4234053", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chemokinesis"}
{"concept_id": "C4234054", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcitonin secretion"}
{"concept_id": "C4234055", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcitonin secretion"}
{"concept_id": "C4234056", "aliases": [], "types": ["T039"], "canonical_name": "activation of spore germination"}
{"concept_id": "C4234057", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of spore germination"}
{"concept_id": "C4234058", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomere maintenance via telomere lengthening"}
{"concept_id": "C4234059", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomere maintenance via telomere lengthening"}
{"concept_id": "C4234060", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomere end protection"}
{"concept_id": "C4234061", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomere capping"}
{"concept_id": "C4234062", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomere end protection"}
{"concept_id": "C4234063", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomere capping"}
{"concept_id": "C4234064", "aliases": ["up-regulation of vacuolar protein degradation", "upregulation of vacuolar protein degradation"], "types": ["T044"], "canonical_name": "up regulation of vacuolar protein degradation"}
{"concept_id": "C4234065", "aliases": ["up-regulation of vacuolar protein catabolism", "upregulation of vacuolar protein catabolism"], "types": ["T044"], "canonical_name": "up regulation of vacuolar protein catabolism"}
{"concept_id": "C4234066", "aliases": ["up-regulation of vacuolar protein catabolic process", "upregulation of vacuolar protein catabolic process"], "types": ["T044"], "canonical_name": "up regulation of vacuolar protein catabolic process"}
{"concept_id": "C4234067", "aliases": ["upregulation of vacuolar protein breakdown", "up-regulation of vacuolar protein breakdown"], "types": ["T044"], "canonical_name": "up regulation of vacuolar protein breakdown"}
{"concept_id": "C4234068", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of vacuolar protein degradation"}
{"concept_id": "C4234069", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of vacuolar protein catabolism"}
{"concept_id": "C4234070", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of vacuolar protein catabolic process"}
{"concept_id": "C4234071", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of vacuolar protein breakdown"}
{"concept_id": "C4234072", "aliases": [], "types": ["T044"], "canonical_name": "activation of vacuolar protein degradation"}
{"concept_id": "C4234073", "aliases": [], "types": ["T044"], "canonical_name": "activation of vacuolar protein catabolism"}
{"concept_id": "C4234074", "aliases": [], "types": ["T044"], "canonical_name": "activation of vacuolar protein catabolic process"}
{"concept_id": "C4234075", "aliases": [], "types": ["T044"], "canonical_name": "activation of vacuolar protein breakdown"}
{"concept_id": "C4234076", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein catabolic process in the vacuole"}
{"concept_id": "C4234077", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of vacuolar protein degradation"}
{"concept_id": "C4234078", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of vacuolar protein catabolism"}
{"concept_id": "C4234079", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of vacuolar protein catabolic process"}
{"concept_id": "C4234080", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of vacuolar protein breakdown"}
{"concept_id": "C4234081", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of vacuolar protein degradation"}
{"concept_id": "C4234082", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of vacuolar protein catabolism"}
{"concept_id": "C4234083", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of vacuolar protein catabolic process"}
{"concept_id": "C4234084", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of vacuolar protein breakdown"}
{"concept_id": "C4234085", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein catabolic process in the vacuole"}
{"concept_id": "C4234086", "aliases": ["down-regulation of vacuolar protein degradation", "downregulation of vacuolar protein degradation"], "types": ["T044"], "canonical_name": "down regulation of vacuolar protein degradation"}
{"concept_id": "C4234087", "aliases": ["downregulation of vacuolar protein catabolism", "down-regulation of vacuolar protein catabolism"], "types": ["T044"], "canonical_name": "down regulation of vacuolar protein catabolism"}
{"concept_id": "C4234088", "aliases": ["downregulation of vacuolar protein catabolic process", "down-regulation of vacuolar protein catabolic process"], "types": ["T044"], "canonical_name": "down regulation of vacuolar protein catabolic process"}
{"concept_id": "C4234089", "aliases": ["down-regulation of vacuolar protein breakdown", "downregulation of vacuolar protein breakdown"], "types": ["T044"], "canonical_name": "down regulation of vacuolar protein breakdown"}
{"concept_id": "C4234090", "aliases": [], "types": ["T044"], "canonical_name": "regulation of vacuolar protein degradation"}
{"concept_id": "C4234091", "aliases": [], "types": ["T044"], "canonical_name": "regulation of vacuolar protein catabolism"}
{"concept_id": "C4234092", "aliases": [], "types": ["T044"], "canonical_name": "regulation of vacuolar protein catabolic process"}
{"concept_id": "C4234093", "aliases": [], "types": ["T044"], "canonical_name": "regulation of vacuolar protein breakdown"}
{"concept_id": "C4234094", "aliases": [], "types": ["T042"], "canonical_name": "activation of small intestine smooth muscle contraction"}
{"concept_id": "C4234095", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of small intestine smooth muscle contraction"}
{"concept_id": "C4234096", "aliases": [], "types": ["T039"], "canonical_name": "activation of stomach mucosal blood circulation"}
{"concept_id": "C4234097", "aliases": [], "types": ["T039"], "canonical_name": "activation of gastric mucosal blood circulation"}
{"concept_id": "C4234098", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of stomach mucosal blood circulation"}
{"concept_id": "C4234099", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of gastric mucosal blood circulation"}
{"concept_id": "C4234100", "aliases": [], "types": ["T042"], "canonical_name": "activation of colon smooth muscle contraction"}
{"concept_id": "C4234101", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of colon smooth muscle contraction"}
{"concept_id": "C4234102", "aliases": [], "types": ["T043"], "canonical_name": "activation of dopaminergic neuron differentiation"}
{"concept_id": "C4234103", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dopaminergic neuron differentiation"}
{"concept_id": "C4234104", "aliases": [], "types": ["T039"], "canonical_name": "activation of ductus arteriosus closure"}
{"concept_id": "C4234105", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of ductus arteriosus closure"}
{"concept_id": "C4234106", "aliases": ["upregulation of mutagenic postreplication DNA repair", "up-regulation of mutagenic postreplication DNA repair"], "types": ["T045"], "canonical_name": "up regulation of mutagenic postreplication DNA repair"}
{"concept_id": "C4234107", "aliases": ["up-regulation of error-prone postreplication DNA repair", "upregulation of error-prone postreplication DNA repair"], "types": ["T045"], "canonical_name": "up regulation of error-prone postreplication DNA repair"}
{"concept_id": "C4234108", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mutagenic postreplication DNA repair"}
{"concept_id": "C4234109", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of error-prone postreplication DNA repair"}
{"concept_id": "C4234110", "aliases": [], "types": ["T045"], "canonical_name": "activation of mutagenic PRR"}
{"concept_id": "C4234111", "aliases": [], "types": ["T045"], "canonical_name": "activation of mutagenic postreplication DNA repair"}
{"concept_id": "C4234112", "aliases": [], "types": ["T045"], "canonical_name": "activation of error-prone translesion synthesis"}
{"concept_id": "C4234113", "aliases": [], "types": ["T045"], "canonical_name": "activation of error-prone postreplication DNA repair"}
{"concept_id": "C4234114", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mutagenic postreplication DNA repair"}
{"concept_id": "C4234115", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of error-prone postreplication DNA repair"}
{"concept_id": "C4234116", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mutagenic PRR"}
{"concept_id": "C4234117", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mutagenic postreplication DNA repair"}
{"concept_id": "C4234118", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of error-prone translesion synthesis"}
{"concept_id": "C4234119", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of error-prone postreplication DNA repair"}
{"concept_id": "C4234120", "aliases": ["downregulation of error-prone postreplication DNA repair", "down-regulation of error-prone postreplication DNA repair"], "types": ["T045"], "canonical_name": "down regulation of error-prone postreplication DNA repair"}
{"concept_id": "C4234121", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mutagenic postreplication DNA repair"}
{"concept_id": "C4234122", "aliases": [], "types": ["T043"], "canonical_name": "regulation of error-prone postreplication DNA repair"}
{"concept_id": "C4234123", "aliases": [], "types": ["T043"], "canonical_name": "activation of myofibroblast contraction"}
{"concept_id": "C4234124", "aliases": [], "types": ["T043"], "canonical_name": "activation of MFB contraction"}
{"concept_id": "C4234125", "aliases": [], "types": ["T043"], "canonical_name": "activation of MF contraction"}
{"concept_id": "C4234126", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myofibroblast contraction"}
{"concept_id": "C4234127", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of MFB contraction"}
{"concept_id": "C4234128", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of MF contraction"}
{"concept_id": "C4234129", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of circadian sleep/wake cycle, wakefulness"}
{"concept_id": "C4234130", "aliases": [], "types": ["T044"], "canonical_name": "activation of inhibitory G-protein coupled receptor phosphorylation"}
{"concept_id": "C4234131", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of inhibitory G-protein coupled receptor phosphorylation"}
{"concept_id": "C4234132", "aliases": ["upregulation of urinary bladder smooth muscle contraction involved in micturition", "up-regulation of urinary bladder smooth muscle contraction involved in micturition"], "types": ["T042"], "canonical_name": "up regulation of urinary bladder smooth muscle contraction involved in micturition"}
{"concept_id": "C4234133", "aliases": ["up-regulation of smooth muscle contraction involved in urination", "upregulation of smooth muscle contraction involved in urination"], "types": ["T042"], "canonical_name": "up regulation of smooth muscle contraction involved in urination"}
{"concept_id": "C4234134", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of urinary bladder smooth muscle contraction involved in micturition"}
{"concept_id": "C4234135", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of smooth muscle contraction involved in urination"}
{"concept_id": "C4234136", "aliases": [], "types": ["T042"], "canonical_name": "activation of urinary bladder smooth muscle contraction involved in micturition"}
{"concept_id": "C4234137", "aliases": [], "types": ["T042"], "canonical_name": "activation of smooth muscle contraction involved in urination"}
{"concept_id": "C4234138", "aliases": [], "types": ["T042"], "canonical_name": "activation of smooth muscle contraction involved in micturition"}
{"concept_id": "C4234139", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of urinary bladder smooth muscle contraction involved in micturition"}
{"concept_id": "C4234140", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of smooth muscle contraction involved in urination"}
{"concept_id": "C4234141", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of urinary bladder smooth muscle contraction involved in micturition"}
{"concept_id": "C4234142", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of smooth muscle contraction involved in urination"}
{"concept_id": "C4234143", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of smooth muscle contraction involved in micturition"}
{"concept_id": "C4234144", "aliases": ["down-regulation of urinary bladder smooth muscle contraction involved in micturition", "downregulation of urinary bladder smooth muscle contraction involved in micturition"], "types": ["T040"], "canonical_name": "down regulation of urinary bladder smooth muscle contraction involved in micturition"}
{"concept_id": "C4234145", "aliases": ["down-regulation of smooth muscle contraction involved in urination", "downregulation of smooth muscle contraction involved in urination"], "types": ["T040"], "canonical_name": "down regulation of smooth muscle contraction involved in urination"}
{"concept_id": "C4234146", "aliases": [], "types": ["T042"], "canonical_name": "regulation of urinary bladder smooth muscle contraction involved in micturition"}
{"concept_id": "C4234147", "aliases": [], "types": ["T042"], "canonical_name": "regulation of smooth muscle contraction involved in urination"}
{"concept_id": "C4234148", "aliases": [], "types": ["T044"], "canonical_name": "ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential"}
{"concept_id": "C4234149", "aliases": [], "types": ["T044"], "canonical_name": "ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential"}
{"concept_id": "C4234150", "aliases": [], "types": ["T042"], "canonical_name": "activation of gastro-intestinal system smooth muscle contraction"}
{"concept_id": "C4234151", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of gastro-intestinal system smooth muscle contraction"}
{"concept_id": "C4234152", "aliases": [], "types": ["T038"], "canonical_name": "activation of maternal process involved in parturition"}
{"concept_id": "C4234153", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of maternal process involved in parturition"}
{"concept_id": "C4234154", "aliases": [], "types": ["T043"], "canonical_name": "activation of transcytosis"}
{"concept_id": "C4234155", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of transcytosis"}
{"concept_id": "C4234156", "aliases": [], "types": ["T044"], "canonical_name": "activation of osmolarity-sensing cation channel activity"}
{"concept_id": "C4234157", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of osmolarity-sensing cation channel activity"}
{"concept_id": "C4234158", "aliases": ["up-regulation of ER-associated degradation pathway", "upregulation of ER-associated degradation pathway"], "types": ["T043"], "canonical_name": "up regulation of ER-associated degradation pathway"}
{"concept_id": "C4234159", "aliases": ["upregulation of endoplasmic reticulum-associated protein degradation pathway", "up-regulation of endoplasmic reticulum-associated protein degradation pathway"], "types": ["T043"], "canonical_name": "up regulation of endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234160", "aliases": ["positive regulation of ER-associated degradation pathway", "up regulation of ERAD pathway", "upregulation of endoplasmic reticulum-associated degradation", "up regulation of endoplasmic reticulum-associated degradation", "up-regulation of ERAD pathway", "up-regulation of endoplasmic reticulum-associated degradation", "positive regulation of endoplasmic reticulum-associated degradation", "upregulation of ERAD pathway"], "types": ["T043"], "canonical_name": "positive regulation of ERAD pathway", "definition": "Any process that activates or increases the frequency, rate or extent of ERAD pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4234161", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234162", "aliases": [], "types": ["T043"], "canonical_name": "activation of ERAD pathway"}
{"concept_id": "C4234163", "aliases": [], "types": ["T043"], "canonical_name": "activation of ER-associated degradation pathway"}
{"concept_id": "C4234164", "aliases": [], "types": ["T043"], "canonical_name": "activation of endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234165", "aliases": [], "types": ["T043"], "canonical_name": "activation of endoplasmic reticulum-associated degradation"}
{"concept_id": "C4234166", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ER-associated degradation pathway"}
{"concept_id": "C4234167", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234168", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ERAD pathway"}
{"concept_id": "C4234169", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ER-associated degradation pathway"}
{"concept_id": "C4234170", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234171", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endoplasmic reticulum-associated degradation"}
{"concept_id": "C4234172", "aliases": ["down-regulation of ER-associated degradation pathway", "downregulation of ER-associated degradation pathway"], "types": ["T043"], "canonical_name": "down regulation of ER-associated degradation pathway"}
{"concept_id": "C4234173", "aliases": ["downregulation of endoplasmic reticulum-associated protein degradation pathway", "down-regulation of endoplasmic reticulum-associated protein degradation pathway"], "types": ["T043"], "canonical_name": "down regulation of endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234174", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ER-associated degradation pathway"}
{"concept_id": "C4234175", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4234176", "aliases": [], "types": ["T045"], "canonical_name": "activation of mitotic DNA damage checkpoint"}
{"concept_id": "C4234177", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic DNA damage checkpoint"}
{"concept_id": "C4234178", "aliases": ["Bag6 complex binding", "BAT3-TRC35-UBL4A complex binding", "BAG6-UBL4A-TRC35 complex binding"], "types": ["T044"], "canonical_name": "BAT3 complex binding", "definition": "Binding to a BAT3 complex. [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23246001]"}
{"concept_id": "C4234179", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein-pyridoxal-5-phosphate linkage"}
{"concept_id": "C4234180", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein-pyridoxal-5-phosphate linkage"}
{"concept_id": "C4234181", "aliases": [], "types": ["T043"], "canonical_name": "activation of endogenous peptide antigen processing and presentation via MHC class I"}
{"concept_id": "C4234182", "aliases": [], "types": ["T039"], "canonical_name": "activation of antigen processing and presentation of endogenous peptide antigen via MHC class I"}
{"concept_id": "C4234183", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endogenous peptide antigen processing and presentation via MHC class I"}
{"concept_id": "C4234184", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of antigen processing and presentation of endogenous peptide antigen via MHC class I"}
{"concept_id": "C4234185", "aliases": [], "types": ["T038"], "canonical_name": "regulation of antigen processing, endogenous antigen via MHC class I"}
{"concept_id": "C4234186", "aliases": [], "types": ["T043"], "canonical_name": "regulation of antigen processing, endogenous antigen via major histocompatibility complex class I"}
{"concept_id": "C4234187", "aliases": [], "types": ["T039"], "canonical_name": "regulation of antigen presentation, endogenous peptide antigen"}
{"concept_id": "C4234188", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription from RNA polymerase V promoter"}
{"concept_id": "C4234189", "aliases": [], "types": ["T045"], "canonical_name": "activation of transcription from RNA pol V promoter"}
{"concept_id": "C4234190", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription from RNA polymerase V promoter"}
{"concept_id": "C4234191", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of transcription from RNA pol V promoter"}
{"concept_id": "C4234192", "aliases": [], "types": ["T038"], "canonical_name": "activation of wax synthesis"}
{"concept_id": "C4234193", "aliases": [], "types": ["T043"], "canonical_name": "activation of wax formation"}
{"concept_id": "C4234194", "aliases": ["activation of wax biosynthetic process"], "types": ["T038"], "canonical_name": "activation of wax biosynthesis"}
{"concept_id": "C4234195", "aliases": [], "types": ["T043"], "canonical_name": "activation of wax anabolism"}
{"concept_id": "C4234196", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of wax synthesis"}
{"concept_id": "C4234197", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of wax formation"}
{"concept_id": "C4234198", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of wax biosynthetic process"}
{"concept_id": "C4234199", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of wax biosynthesis"}
{"concept_id": "C4234200", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of wax anabolism"}
{"concept_id": "C4234201", "aliases": ["peripheral cytoplasm of leading edge of cell"], "types": ["T026"], "canonical_name": "peripheral cytoplasm of cell leading edge"}
{"concept_id": "C4234202", "aliases": [], "types": ["T026"], "canonical_name": "peripheral cytoplasm of front of cell"}
{"concept_id": "C4234203", "aliases": ["cell periphery of leading edge of cell"], "types": ["T026"], "canonical_name": "cell periphery of cell leading edge"}
{"concept_id": "C4234204", "aliases": [], "types": ["T026"], "canonical_name": "cell periphery of front of cell"}
{"concept_id": "C4234205", "aliases": [], "types": ["T043"], "canonical_name": "activation of Schwann cell chemotaxis"}
{"concept_id": "C4234206", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Schwann cell chemotaxis"}
{"concept_id": "C4234236", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin-specific protease activity involved in negative regulation of ERAD pathway"}
{"concept_id": "C4234251", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin ligase activity involved in ER-associated degradation pathway"}
{"concept_id": "C4234260", "aliases": [], "types": ["T044"], "canonical_name": "activation of TORC1 signaling"}
{"concept_id": "C4234261", "aliases": [], "types": ["T044"], "canonical_name": "activation of TORC1 signal transduction"}
{"concept_id": "C4234262", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of TORC1 signaling"}
{"concept_id": "C4234263", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of TORC1 signal transduction"}
{"concept_id": "C4234264", "aliases": [], "types": ["T040"], "canonical_name": "activation of basement membrane assembly involved in embryonic body morphogenesis"}
{"concept_id": "C4234265", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of basement membrane assembly involved in embryonic body morphogenesis"}
{"concept_id": "C4234266", "aliases": [], "types": ["T043"], "canonical_name": "activation of iron-specific channel activity"}
{"concept_id": "C4234267", "aliases": [], "types": ["T043"], "canonical_name": "activation of iron channel activity"}
{"concept_id": "C4234268", "aliases": [], "types": ["T043"], "canonical_name": "activation of iron cation channel activity"}
{"concept_id": "C4234269", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of iron-specific channel activity"}
{"concept_id": "C4234270", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of iron channel activity"}
{"concept_id": "C4234271", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of iron cation channel activity"}
{"concept_id": "C4234272", "aliases": [], "types": ["T044"], "canonical_name": "activation of bile acid metabolism"}
{"concept_id": "C4234273", "aliases": [], "types": ["T044"], "canonical_name": "activation of bile acid metabolic process"}
{"concept_id": "C4234274", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bile acid metabolism"}
{"concept_id": "C4234275", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bile acid metabolic process"}
{"concept_id": "C4234276", "aliases": ["upregulation of senescence-induced resistance", "up-regulation of senescence-induced resistance"], "types": ["T040"], "canonical_name": "up regulation of senescence-induced resistance"}
{"concept_id": "C4234277", "aliases": ["up-regulation of mature seedling resistance", "upregulation of mature seedling resistance"], "types": ["T040"], "canonical_name": "up regulation of mature seedling resistance"}
{"concept_id": "C4234278", "aliases": ["up-regulation of flowering-induced resistance", "upregulation of flowering-induced resistance"], "types": ["T040"], "canonical_name": "up regulation of flowering-induced resistance"}
{"concept_id": "C4234279", "aliases": ["upregulation of adult seedling resistance", "up-regulation of adult seedling resistance"], "types": ["T040"], "canonical_name": "up regulation of adult seedling resistance"}
{"concept_id": "C4234280", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of senescence-induced resistance"}
{"concept_id": "C4234281", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of mature seedling resistance"}
{"concept_id": "C4234282", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of flowering-induced resistance"}
{"concept_id": "C4234283", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of adult seedling resistance"}
{"concept_id": "C4234284", "aliases": [], "types": ["T040"], "canonical_name": "activation of senescence-induced resistance"}
{"concept_id": "C4234285", "aliases": [], "types": ["T040"], "canonical_name": "activation of flowering-induced resistance"}
{"concept_id": "C4234286", "aliases": [], "types": ["T040"], "canonical_name": "activation of ARR"}
{"concept_id": "C4234287", "aliases": [], "types": ["T040"], "canonical_name": "activation of age-related resistance"}
{"concept_id": "C4234288", "aliases": [], "types": ["T040"], "canonical_name": "activation of adult seedling resistance"}
{"concept_id": "C4234289", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of senescence-induced resistance"}
{"concept_id": "C4234290", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of mature seedling resistance"}
{"concept_id": "C4234291", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of flowering-induced resistance"}
{"concept_id": "C4234292", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of adult seedling resistance"}
{"concept_id": "C4234293", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of senescence-induced resistance"}
{"concept_id": "C4234294", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of mature seedling resistance"}
{"concept_id": "C4234295", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of flowering-induced resistance"}
{"concept_id": "C4234296", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of ARR"}
{"concept_id": "C4234297", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of age-related resistance"}
{"concept_id": "C4234298", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of adult seedling resistance"}
{"concept_id": "C4234299", "aliases": ["down-regulation of senescence-induced resistance", "downregulation of senescence-induced resistance"], "types": ["T040"], "canonical_name": "down regulation of senescence-induced resistance"}
{"concept_id": "C4234300", "aliases": ["downregulation of mature seedling resistance", "down-regulation of mature seedling resistance"], "types": ["T040"], "canonical_name": "down regulation of mature seedling resistance"}
{"concept_id": "C4234301", "aliases": ["downregulation of flowering-induced resistance", "down-regulation of flowering-induced resistance"], "types": ["T040"], "canonical_name": "down regulation of flowering-induced resistance"}
{"concept_id": "C4234302", "aliases": ["down-regulation of adult seedling resistance", "downregulation of adult seedling resistance"], "types": ["T040"], "canonical_name": "down regulation of adult seedling resistance"}
{"concept_id": "C4234303", "aliases": [], "types": ["T040"], "canonical_name": "regulation of senescence-induced resistance"}
{"concept_id": "C4234304", "aliases": [], "types": ["T040"], "canonical_name": "regulation of ontogenic resistance"}
{"concept_id": "C4234305", "aliases": [], "types": ["T040"], "canonical_name": "regulation of mature seedling resistance"}
{"concept_id": "C4234306", "aliases": [], "types": ["T040"], "canonical_name": "regulation of flowering-induced resistance"}
{"concept_id": "C4234307", "aliases": [], "types": ["T040"], "canonical_name": "regulation of developmental resistance"}
{"concept_id": "C4234308", "aliases": [], "types": ["T040"], "canonical_name": "regulation of adult seedling resistance"}
{"concept_id": "C4234309", "aliases": ["up-regulation of RNA formation factors, PF1", "upregulation of RNA formation factors, PF1"], "types": ["T044"], "canonical_name": "up regulation of RNA formation factors, PF1"}
{"concept_id": "C4234310", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of RNA formation factors, PF1"}
{"concept_id": "C4234311", "aliases": [], "types": ["T044"], "canonical_name": "activation of terminal riboadenylate transferase activity"}
{"concept_id": "C4234312", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNA formation factors, PF1"}
{"concept_id": "C4234313", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNA adenylating enzyme activity"}
{"concept_id": "C4234314", "aliases": [], "types": ["T044"], "canonical_name": "activation of polynucleotide adenylyltransferase activity"}
{"concept_id": "C4234315", "aliases": [], "types": ["T044"], "canonical_name": "activation of polyadenylic polymerase activity"}
{"concept_id": "C4234316", "aliases": [], "types": ["T044"], "canonical_name": "activation of polyadenylic acid polymerase activity"}
{"concept_id": "C4234317", "aliases": [], "types": ["T044"], "canonical_name": "activation of polyadenylate synthetase activity"}
{"concept_id": "C4234318", "aliases": [], "types": ["T044"], "canonical_name": "activation of polyadenylate polymerase activity"}
{"concept_id": "C4234319", "aliases": [], "types": ["T044"], "canonical_name": "activation of polyadenylate nucleotidyltransferase activity"}
{"concept_id": "C4234320", "aliases": ["activation of poly-A polymerase activity"], "types": ["T044"], "canonical_name": "activation of poly(A) polymerase activity"}
{"concept_id": "C4234321", "aliases": [], "types": ["T044"], "canonical_name": "activation of poly(A) synthetase activity"}
{"concept_id": "C4234322", "aliases": [], "types": ["T044"], "canonical_name": "activation of poly(A) hydrolase activity"}
{"concept_id": "C4234323", "aliases": [], "types": ["T044"], "canonical_name": "activation of NTP polymerase activity"}
{"concept_id": "C4234324", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATP:polynucleotidylexotransferase activity"}
{"concept_id": "C4234325", "aliases": ["activation of ATP:polynucleotide adenylyltransferase activity"], "types": ["T044"], "canonical_name": "activation of ATP-polynucleotide adenylyltransferase activity"}
{"concept_id": "C4234326", "aliases": [], "types": ["T044"], "canonical_name": "activation of AMP polynucleotidylexotransferase activity"}
{"concept_id": "C4234327", "aliases": [], "types": ["T044"], "canonical_name": "activation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity"}
{"concept_id": "C4234328", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of RNA formation factors, PF1"}
{"concept_id": "C4234329", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of terminal riboadenylate transferase activity"}
{"concept_id": "C4234330", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA formation factors, PF1"}
{"concept_id": "C4234331", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA adenylating enzyme activity"}
{"concept_id": "C4234332", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polynucleotide adenylyltransferase activity"}
{"concept_id": "C4234333", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polyadenylic polymerase activity"}
{"concept_id": "C4234334", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polyadenylic acid polymerase activity"}
{"concept_id": "C4234335", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polyadenylate synthetase activity"}
{"concept_id": "C4234336", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polyadenylate polymerase activity"}
{"concept_id": "C4234337", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polyadenylate nucleotidyltransferase activity"}
{"concept_id": "C4234338", "aliases": ["inhibition of poly-A polymerase activity"], "types": ["T044"], "canonical_name": "inhibition of poly(A) polymerase activity"}
{"concept_id": "C4234339", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of poly(A) synthetase activity"}
{"concept_id": "C4234340", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of poly(A) hydrolase activity"}
{"concept_id": "C4234341", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of NTP polymerase activity"}
{"concept_id": "C4234342", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATP:polynucleotidylexotransferase activity"}
{"concept_id": "C4234343", "aliases": ["inhibition of ATP:polynucleotide adenylyltransferase activity"], "types": ["T044"], "canonical_name": "inhibition of ATP-polynucleotide adenylyltransferase activity"}
{"concept_id": "C4234344", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of AMP polynucleotidylexotransferase activity"}
{"concept_id": "C4234345", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of adenosine triphosphate:ribonucleic acid adenylyltransferase activity"}
{"concept_id": "C4234346", "aliases": ["downregulation of RNA formation factors, PF1", "down-regulation of RNA formation factors, PF1"], "types": ["T044"], "canonical_name": "down regulation of RNA formation factors, PF1"}
{"concept_id": "C4234347", "aliases": [], "types": ["T044"], "canonical_name": "regulation of RNA formation factors, PF1"}
{"concept_id": "C4234348", "aliases": [], "types": ["T043"], "canonical_name": "activation of pancreatic trypsinogen secretion"}
{"concept_id": "C4234349", "aliases": [], "types": ["T043"], "canonical_name": "activation of pancreatic trypsinogen release"}
{"concept_id": "C4234350", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pancreatic trypsinogen secretion"}
{"concept_id": "C4234351", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of pancreatic trypsinogen release"}
{"concept_id": "C4234352", "aliases": ["up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation", "upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"], "types": ["T043"], "canonical_name": "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"}
{"concept_id": "C4234353", "aliases": ["upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly", "up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"], "types": ["T043"], "canonical_name": "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"}
{"concept_id": "C4234354", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"}
{"concept_id": "C4234355", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"}
{"concept_id": "C4234356", "aliases": [], "types": ["T043"], "canonical_name": "activation of VCP-NPL4-UFD1 AAA ATPase complex formation"}
{"concept_id": "C4234357", "aliases": [], "types": ["T043"], "canonical_name": "activation of VCP-NPL4-UFD1 AAA ATPase complex assembly"}
{"concept_id": "C4234358", "aliases": [], "types": ["T043"], "canonical_name": "activation of p97-Ufd1-Npl4 complex formation"}
{"concept_id": "C4234359", "aliases": [], "types": ["T043"], "canonical_name": "activation of p97-Ufd1-Npl4 complex assembly"}
{"concept_id": "C4234360", "aliases": [], "types": ["T043"], "canonical_name": "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"}
{"concept_id": "C4234361", "aliases": [], "types": ["T043"], "canonical_name": "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"}
{"concept_id": "C4234362", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"}
{"concept_id": "C4234363", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"}
{"concept_id": "C4234364", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of VCP-NPL4-UFD1 AAA ATPase complex formation"}
{"concept_id": "C4234365", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of VCP-NPL4-UFD1 AAA ATPase complex assembly"}
{"concept_id": "C4234366", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of p97-Ufd1-Npl4 complex formation"}
{"concept_id": "C4234367", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of p97-Ufd1-Npl4 complex assembly"}
{"concept_id": "C4234368", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"}
{"concept_id": "C4234369", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"}
{"concept_id": "C4234370", "aliases": ["down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation", "downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"], "types": ["T043"], "canonical_name": "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"}
{"concept_id": "C4234371", "aliases": ["downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly", "down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"], "types": ["T043"], "canonical_name": "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"}
{"concept_id": "C4234372", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"}
{"concept_id": "C4234373", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"}
{"concept_id": "C4234374", "aliases": [], "types": ["T043"], "canonical_name": "activation of substrate-dependent cell migration, cell attachment to substrate"}
{"concept_id": "C4234375", "aliases": [], "types": ["T043"], "canonical_name": "activation of substrate-bound cell migration, cell attachment to substrate"}
{"concept_id": "C4234376", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of substrate-dependent cell migration, cell attachment to substrate"}
{"concept_id": "C4234377", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of substrate-bound cell migration, cell attachment to substrate"}
{"concept_id": "C4234378", "aliases": [], "types": ["T044"], "canonical_name": "activation of citrate(isocitrate) hydro-lyase activity"}
{"concept_id": "C4234379", "aliases": [], "types": ["T044"], "canonical_name": "activation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)"}
{"concept_id": "C4234380", "aliases": [], "types": ["T044"], "canonical_name": "activation of cis-aconitase activity"}
{"concept_id": "C4234381", "aliases": [], "types": ["T044"], "canonical_name": "activation of aconitate hydratase activity"}
{"concept_id": "C4234382", "aliases": [], "types": ["T044"], "canonical_name": "activation of aconitase activity"}
{"concept_id": "C4234383", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of citrate(isocitrate) hydro-lyase activity"}
{"concept_id": "C4234384", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)"}
{"concept_id": "C4234385", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cis-aconitase activity"}
{"concept_id": "C4234386", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aconitate hydratase activity"}
{"concept_id": "C4234387", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aconitase activity"}
{"concept_id": "C4234388", "aliases": [], "types": ["T044"], "canonical_name": "regulation of citrate hydro-lyase activity"}
{"concept_id": "C4234389", "aliases": [], "types": ["T044"], "canonical_name": "activation of succinyl dehydrogenase activity"}
{"concept_id": "C4234390", "aliases": [], "types": ["T044"], "canonical_name": "activation of succinodehydrogenase activity"}
{"concept_id": "C4234391", "aliases": [], "types": ["T044"], "canonical_name": "activation of succinic acid dehydrogenase activity"}
{"concept_id": "C4234392", "aliases": ["activation of succinate:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "activation of succinate:(acceptor) oxidoreductase activity"}
{"concept_id": "C4234393", "aliases": [], "types": ["T044"], "canonical_name": "activation of succinate oxidoreductase activity"}
{"concept_id": "C4234394", "aliases": [], "types": ["T044"], "canonical_name": "activation of succinate dehydrogenase activity"}
{"concept_id": "C4234395", "aliases": [], "types": ["T044"], "canonical_name": "activation of fumaric hydrogenase activity"}
{"concept_id": "C4234396", "aliases": [], "types": ["T044"], "canonical_name": "activation of fumarate reductase activity"}
{"concept_id": "C4234397", "aliases": [], "types": ["T044"], "canonical_name": "activation of fumarate dehydrogenase activity"}
{"concept_id": "C4234398", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of succinyl dehydrogenase activity"}
{"concept_id": "C4234399", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of succinodehydrogenase activity"}
{"concept_id": "C4234400", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of succinic acid dehydrogenase activity"}
{"concept_id": "C4234401", "aliases": ["inhibition of succinate:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "inhibition of succinate:(acceptor) oxidoreductase activity"}
{"concept_id": "C4234402", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of succinate oxidoreductase activity"}
{"concept_id": "C4234403", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of succinate dehydrogenase activity"}
{"concept_id": "C4234404", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of fumaric hydrogenase activity"}
{"concept_id": "C4234405", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of fumarate reductase activity"}
{"concept_id": "C4234406", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of fumarate dehydrogenase activity"}
{"concept_id": "C4234407", "aliases": [], "types": ["T044"], "canonical_name": "regulation of succinic dehydrogenase activity"}
{"concept_id": "C4234408", "aliases": [], "types": ["T044"], "canonical_name": "activation of glycogen synthase activity, transferring glucose-1-phosphate"}
{"concept_id": "C4234409", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glycogen synthase activity, transferring glucose-1-phosphate"}
{"concept_id": "C4234410", "aliases": ["up-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity", "upregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234411", "aliases": ["upregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity", "up-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234412", "aliases": ["up-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity", "upregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234413", "aliases": ["upregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity", "up-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity"}
{"concept_id": "C4234414", "aliases": ["upregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity", "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"}
{"concept_id": "C4234415", "aliases": ["upregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity", "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"}
{"concept_id": "C4234416", "aliases": ["up-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity", "upregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234417", "aliases": ["up-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity", "upregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"}
{"concept_id": "C4234418", "aliases": ["upregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity", "up-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"], "types": ["T044"], "canonical_name": "up regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"}
{"concept_id": "C4234419", "aliases": ["up-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity", "upregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234420", "aliases": ["up-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity", "upregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234421", "aliases": ["up-regulation of UDP glucuronate-estriol glucuronosyltransferase activity", "upregulation of UDP glucuronate-estriol glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of UDP glucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234422", "aliases": ["up-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity", "upregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity"}
{"concept_id": "C4234423", "aliases": ["up-regulation of pnp-UDPGT activity", "upregulation of pnp-UDPGT activity"], "types": ["T044"], "canonical_name": "up regulation of pnp-UDPGT activity"}
{"concept_id": "C4234424", "aliases": ["upregulation of PNP-UDPGT", "up-regulation of PNP-UDPGT"], "types": ["T044"], "canonical_name": "up regulation of PNP-UDPGT"}
{"concept_id": "C4234425", "aliases": ["up-regulation of phenyl-UDP-glucuronosyltransferase activity", "upregulation of phenyl-UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of phenyl-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234426", "aliases": ["upregulation of p-phenylphenol glucuronyltransferase activity", "up-regulation of p-phenylphenol glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of p-phenylphenol glucuronyltransferase activity"}
{"concept_id": "C4234427", "aliases": ["up-regulation of p-nitrophenylglucuronosyltransferase activity", "upregulation of p-nitrophenylglucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of p-nitrophenylglucuronosyltransferase activity"}
{"concept_id": "C4234428", "aliases": ["upregulation of p-nitrophenol UDP-glucuronyltransferase activity", "up-regulation of p-nitrophenol UDP-glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of p-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234429", "aliases": ["up-regulation of p-nitrophenol UDP-glucuronosyltransferase activity", "upregulation of p-nitrophenol UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of p-nitrophenol UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234430", "aliases": ["upregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity", "up-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity"}
{"concept_id": "C4234431", "aliases": ["up-regulation of morphine glucuronyltransferase activity", "upregulation of morphine glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of morphine glucuronyltransferase activity"}
{"concept_id": "C4234432", "aliases": ["up-regulation of estrone UDPglucuronosyltransferase activity", "upregulation of estrone UDPglucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of estrone UDPglucuronosyltransferase activity"}
{"concept_id": "C4234433", "aliases": ["upregulation of estriol UDPglucuronosyltransferase activity", "up-regulation of estriol UDPglucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of estriol UDPglucuronosyltransferase activity"}
{"concept_id": "C4234434", "aliases": ["upregulation of ciramadol UDP-glucuronyltransferase activity", "up-regulation of ciramadol UDP-glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of ciramadol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234435", "aliases": ["upregulation of bilirubin uridine diphosphoglucuronyltransferase activity", "up-regulation of bilirubin uridine diphosphoglucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of bilirubin uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234436", "aliases": ["upregulation of bilirubin UDPGT activity", "up-regulation of bilirubin UDPGT activity"], "types": ["T044"], "canonical_name": "up regulation of bilirubin UDPGT activity"}
{"concept_id": "C4234437", "aliases": ["upregulation of bilirubin UDP-glucuronosyltransferase activity", "up-regulation of bilirubin UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of bilirubin UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234438", "aliases": ["up-regulation of bilirubin monoglucuronide glucuronyltransferase activity", "upregulation of bilirubin monoglucuronide glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of bilirubin monoglucuronide glucuronyltransferase activity"}
{"concept_id": "C4234439", "aliases": ["upregulation of bilirubin glucuronyltransferase activity", "up-regulation of bilirubin glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234440", "aliases": ["up-regulation of 4-nitrophenol UDPGT activity", "upregulation of 4-nitrophenol UDPGT activity"], "types": ["T044"], "canonical_name": "up regulation of 4-nitrophenol UDPGT activity"}
{"concept_id": "C4234441", "aliases": ["up-regulation of 4-nitrophenol UDP-glucuronyltransferase activity", "upregulation of 4-nitrophenol UDP-glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of 4-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234442", "aliases": ["up-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity", "upregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234443", "aliases": ["up-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity", "upregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234444", "aliases": ["upregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity", "up-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234445", "aliases": ["up-regulation of 3-OH androgenic UDPGT activity", "upregulation of 3-OH androgenic UDPGT activity"], "types": ["T044"], "canonical_name": "up regulation of 3-OH androgenic UDPGT activity"}
{"concept_id": "C4234446", "aliases": ["up-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity", "upregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234447", "aliases": ["up-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity", "upregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234448", "aliases": ["up-regulation of 17-OH steroid UDPGT activity", "upregulation of 17-OH steroid UDPGT activity"], "types": ["T044"], "canonical_name": "up regulation of 17-OH steroid UDPGT activity"}
{"concept_id": "C4234449", "aliases": ["up-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity", "upregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234450", "aliases": ["up-regulation of 1-naphthol-UDP-glucuronosyltransferase activity", "upregulation of 1-naphthol-UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of 1-naphthol-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234451", "aliases": ["up-regulation of 1-naphthol glucuronyltransferase activity", "upregulation of 1-naphthol glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "up regulation of 1-naphthol glucuronyltransferase activity"}
{"concept_id": "C4234452", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234453", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234454", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234455", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity"}
{"concept_id": "C4234456", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"}
{"concept_id": "C4234457", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"}
{"concept_id": "C4234458", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234459", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"}
{"concept_id": "C4234460", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"}
{"concept_id": "C4234461", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234462", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234463", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of UDP glucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234464", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity"}
{"concept_id": "C4234465", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pnp-UDPGT activity"}
{"concept_id": "C4234466", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of PNP-UDPGT"}
{"concept_id": "C4234467", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phenyl-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234468", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of p-phenylphenol glucuronyltransferase activity"}
{"concept_id": "C4234469", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of p-nitrophenylglucuronosyltransferase activity"}
{"concept_id": "C4234470", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of p-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234471", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of p-nitrophenol UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234472", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity"}
{"concept_id": "C4234473", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of morphine glucuronyltransferase activity"}
{"concept_id": "C4234474", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of estrone UDPglucuronosyltransferase activity"}
{"concept_id": "C4234475", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of estriol UDPglucuronosyltransferase activity"}
{"concept_id": "C4234476", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ciramadol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234477", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of bilirubin uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234478", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of bilirubin UDPGT activity"}
{"concept_id": "C4234479", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of bilirubin UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234480", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of bilirubin monoglucuronide glucuronyltransferase activity"}
{"concept_id": "C4234481", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234482", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 4-nitrophenol UDPGT activity"}
{"concept_id": "C4234483", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 4-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234484", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234485", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234486", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234487", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 3-OH androgenic UDPGT activity"}
{"concept_id": "C4234488", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234489", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234490", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 17-OH steroid UDPGT activity"}
{"concept_id": "C4234491", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234492", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 1-naphthol-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234493", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 1-naphthol glucuronyltransferase activity"}
{"concept_id": "C4234494", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234495", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronosyltransferase activity"}
{"concept_id": "C4234496", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234497", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234498", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234499", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity"}
{"concept_id": "C4234500", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"}
{"concept_id": "C4234501", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"}
{"concept_id": "C4234502", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234503", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"}
{"concept_id": "C4234504", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine diphosphate glucuronyltransferase activity"}
{"concept_id": "C4234505", "aliases": [], "types": ["T044"], "canonical_name": "activation of uridine 5'-diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234506", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDPGT activity"}
{"concept_id": "C4234507", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"}
{"concept_id": "C4234508", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDPGA-glucuronyltransferase activity"}
{"concept_id": "C4234509", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDPGA transferase activity"}
{"concept_id": "C4234510", "aliases": ["activation of UDP-glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "activation of UDP glucuronyltransferase activity"}
{"concept_id": "C4234511", "aliases": ["activation of UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "activation of UDP glucuronosyltransferase activity"}
{"concept_id": "C4234512", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDP-glucuronate-bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234513", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234514", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)"}
{"concept_id": "C4234515", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDP glucuronic acid transferase activity"}
{"concept_id": "C4234516", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDP glucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234517", "aliases": [], "types": ["T044"], "canonical_name": "activation of UDP glucuronate-estradiol-glucuronosyltransferase activity"}
{"concept_id": "C4234518", "aliases": [], "types": ["T044"], "canonical_name": "activation of pnp-UDPGT activity"}
{"concept_id": "C4234519", "aliases": [], "types": ["T044"], "canonical_name": "activation of PNP-UDPGT"}
{"concept_id": "C4234520", "aliases": [], "types": ["T044"], "canonical_name": "activation of phenyl-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234521", "aliases": [], "types": ["T044"], "canonical_name": "activation of p-phenylphenol glucuronyltransferase activity"}
{"concept_id": "C4234522", "aliases": [], "types": ["T044"], "canonical_name": "activation of p-nitrophenylglucuronosyltransferase activity"}
{"concept_id": "C4234523", "aliases": [], "types": ["T044"], "canonical_name": "activation of p-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234524", "aliases": [], "types": ["T044"], "canonical_name": "activation of p-nitrophenol UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234525", "aliases": [], "types": ["T044"], "canonical_name": "activation of p-hydroxybiphenyl UDP glucuronyltransferase activity"}
{"concept_id": "C4234526", "aliases": [], "types": ["T044"], "canonical_name": "activation of morphine glucuronyltransferase activity"}
{"concept_id": "C4234527", "aliases": [], "types": ["T044"], "canonical_name": "activation of GT activity"}
{"concept_id": "C4234528", "aliases": [], "types": ["T044"], "canonical_name": "activation of glucuronosyltransferase activity"}
{"concept_id": "C4234529", "aliases": [], "types": ["T044"], "canonical_name": "activation of estrone UDPglucuronosyltransferase activity"}
{"concept_id": "C4234530", "aliases": [], "types": ["T044"], "canonical_name": "activation of estriol UDPglucuronosyltransferase activity"}
{"concept_id": "C4234531", "aliases": [], "types": ["T044"], "canonical_name": "activation of ciramadol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234532", "aliases": [], "types": ["T044"], "canonical_name": "activation of bilirubin uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234533", "aliases": [], "types": ["T044"], "canonical_name": "activation of bilirubin UDPGT activity"}
{"concept_id": "C4234534", "aliases": [], "types": ["T044"], "canonical_name": "activation of bilirubin UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234535", "aliases": [], "types": ["T044"], "canonical_name": "activation of bilirubin monoglucuronide glucuronyltransferase activity"}
{"concept_id": "C4234536", "aliases": [], "types": ["T044"], "canonical_name": "activation of bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234537", "aliases": [], "types": ["T044"], "canonical_name": "activation of 4-nitrophenol UDPGT activity"}
{"concept_id": "C4234538", "aliases": [], "types": ["T044"], "canonical_name": "activation of 4-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234539", "aliases": [], "types": ["T044"], "canonical_name": "activation of 4-methylumbelliferone UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234540", "aliases": [], "types": ["T044"], "canonical_name": "activation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234541", "aliases": [], "types": ["T044"], "canonical_name": "activation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234542", "aliases": [], "types": ["T044"], "canonical_name": "activation of 3-OH androgenic UDPGT activity"}
{"concept_id": "C4234543", "aliases": [], "types": ["T044"], "canonical_name": "activation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234544", "aliases": [], "types": ["T044"], "canonical_name": "activation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234545", "aliases": [], "types": ["T044"], "canonical_name": "activation of 17-OH steroid UDPGT activity"}
{"concept_id": "C4234546", "aliases": [], "types": ["T044"], "canonical_name": "activation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234547", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1-naphthol-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234548", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1-naphthol glucuronyltransferase activity"}
{"concept_id": "C4234549", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234550", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234551", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234552", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity"}
{"concept_id": "C4234553", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"}
{"concept_id": "C4234554", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"}
{"concept_id": "C4234555", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234556", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"}
{"concept_id": "C4234557", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"}
{"concept_id": "C4234558", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234559", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234560", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of UDP glucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234561", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity"}
{"concept_id": "C4234562", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of pnp-UDPGT activity"}
{"concept_id": "C4234563", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of PNP-UDPGT"}
{"concept_id": "C4234564", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phenyl-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234565", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of p-phenylphenol glucuronyltransferase activity"}
{"concept_id": "C4234566", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of p-nitrophenylglucuronosyltransferase activity"}
{"concept_id": "C4234567", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of p-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234568", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of p-nitrophenol UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234569", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity"}
{"concept_id": "C4234570", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of morphine glucuronyltransferase activity"}
{"concept_id": "C4234571", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of estrone UDPglucuronosyltransferase activity"}
{"concept_id": "C4234572", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of estriol UDPglucuronosyltransferase activity"}
{"concept_id": "C4234573", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ciramadol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234574", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of bilirubin uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234575", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of bilirubin UDPGT activity"}
{"concept_id": "C4234576", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of bilirubin UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234577", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of bilirubin monoglucuronide glucuronyltransferase activity"}
{"concept_id": "C4234578", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234579", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 4-nitrophenol UDPGT activity"}
{"concept_id": "C4234580", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 4-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234581", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234582", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234583", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234584", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 3-OH androgenic UDPGT activity"}
{"concept_id": "C4234585", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234586", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234587", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 17-OH steroid UDPGT activity"}
{"concept_id": "C4234588", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234589", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 1-naphthol-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234590", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 1-naphthol glucuronyltransferase activity"}
{"concept_id": "C4234591", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234592", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronosyltransferase activity"}
{"concept_id": "C4234593", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234594", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234595", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234596", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity"}
{"concept_id": "C4234597", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"}
{"concept_id": "C4234598", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"}
{"concept_id": "C4234599", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234600", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"}
{"concept_id": "C4234601", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine diphosphate glucuronyltransferase activity"}
{"concept_id": "C4234602", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of uridine 5'-diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234603", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDPGT activity"}
{"concept_id": "C4234604", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"}
{"concept_id": "C4234605", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDPGA-glucuronyltransferase activity"}
{"concept_id": "C4234606", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDPGA transferase activity"}
{"concept_id": "C4234607", "aliases": ["inhibition of UDP-glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "inhibition of UDP glucuronyltransferase activity"}
{"concept_id": "C4234608", "aliases": ["inhibition of UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "inhibition of UDP glucuronosyltransferase activity"}
{"concept_id": "C4234609", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDP-glucuronate-bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234610", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234611", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)"}
{"concept_id": "C4234612", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDP glucuronic acid transferase activity"}
{"concept_id": "C4234613", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDP glucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234614", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of UDP glucuronate-estradiol-glucuronosyltransferase activity"}
{"concept_id": "C4234615", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pnp-UDPGT activity"}
{"concept_id": "C4234616", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of PNP-UDPGT"}
{"concept_id": "C4234617", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phenyl-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234618", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of p-phenylphenol glucuronyltransferase activity"}
{"concept_id": "C4234619", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of p-nitrophenylglucuronosyltransferase activity"}
{"concept_id": "C4234620", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of p-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234621", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of p-nitrophenol UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234622", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of p-hydroxybiphenyl UDP glucuronyltransferase activity"}
{"concept_id": "C4234623", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of morphine glucuronyltransferase activity"}
{"concept_id": "C4234624", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of GT activity"}
{"concept_id": "C4234625", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glucuronosyltransferase activity"}
{"concept_id": "C4234626", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of estrone UDPglucuronosyltransferase activity"}
{"concept_id": "C4234627", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of estriol UDPglucuronosyltransferase activity"}
{"concept_id": "C4234628", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ciramadol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234629", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bilirubin uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234630", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bilirubin UDPGT activity"}
{"concept_id": "C4234631", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bilirubin UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234632", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bilirubin monoglucuronide glucuronyltransferase activity"}
{"concept_id": "C4234633", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234634", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 4-nitrophenol UDPGT activity"}
{"concept_id": "C4234635", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 4-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234636", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 4-methylumbelliferone UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234637", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234638", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234639", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 3-OH androgenic UDPGT activity"}
{"concept_id": "C4234640", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234641", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234642", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 17-OH steroid UDPGT activity"}
{"concept_id": "C4234643", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234644", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1-naphthol-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234645", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1-naphthol glucuronyltransferase activity"}
{"concept_id": "C4234646", "aliases": ["downregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity", "down-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234647", "aliases": ["downregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity", "down-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity", "down-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity", "downregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity", "down regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234648", "aliases": ["downregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity", "down-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity"}
{"concept_id": "C4234649", "aliases": ["down-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity", "downregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"}
{"concept_id": "C4234650", "aliases": ["down-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity", "downregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"}
{"concept_id": "C4234651", "aliases": ["downregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity", "down-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234652", "aliases": ["down-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity", "downregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"}
{"concept_id": "C4234653", "aliases": ["downregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity", "down-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"], "types": ["T044"], "canonical_name": "down regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"}
{"concept_id": "C4234654", "aliases": ["down-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity", "downregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234655", "aliases": ["downregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity", "down-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234656", "aliases": ["down-regulation of UDP glucuronate-estriol glucuronosyltransferase activity", "downregulation of UDP glucuronate-estriol glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of UDP glucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234657", "aliases": ["downregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity", "down-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity"}
{"concept_id": "C4234658", "aliases": ["down-regulation of pnp-UDPGT activity", "downregulation of pnp-UDPGT activity"], "types": ["T044"], "canonical_name": "down regulation of pnp-UDPGT activity"}
{"concept_id": "C4234659", "aliases": ["down-regulation of PNP-UDPGT", "downregulation of PNP-UDPGT"], "types": ["T044"], "canonical_name": "down regulation of PNP-UDPGT"}
{"concept_id": "C4234660", "aliases": ["downregulation of phenyl-UDP-glucuronosyltransferase activity", "down-regulation of phenyl-UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of phenyl-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234661", "aliases": ["downregulation of p-phenylphenol glucuronyltransferase activity", "down-regulation of p-phenylphenol glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of p-phenylphenol glucuronyltransferase activity"}
{"concept_id": "C4234662", "aliases": ["downregulation of p-nitrophenylglucuronosyltransferase activity", "down-regulation of p-nitrophenylglucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of p-nitrophenylglucuronosyltransferase activity"}
{"concept_id": "C4234663", "aliases": ["down-regulation of p-nitrophenol UDP-glucuronyltransferase activity", "downregulation of p-nitrophenol UDP-glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of p-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234664", "aliases": ["down-regulation of p-nitrophenol UDP-glucuronosyltransferase activity", "downregulation of p-nitrophenol UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of p-nitrophenol UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234665", "aliases": ["downregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity", "down-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity"}
{"concept_id": "C4234666", "aliases": ["down-regulation of morphine glucuronyltransferase activity", "downregulation of morphine glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of morphine glucuronyltransferase activity"}
{"concept_id": "C4234667", "aliases": ["down-regulation of estrone UDPglucuronosyltransferase activity", "downregulation of estrone UDPglucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of estrone UDPglucuronosyltransferase activity"}
{"concept_id": "C4234668", "aliases": ["down-regulation of estriol UDPglucuronosyltransferase activity", "downregulation of estriol UDPglucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of estriol UDPglucuronosyltransferase activity"}
{"concept_id": "C4234669", "aliases": ["downregulation of ciramadol UDP-glucuronyltransferase activity", "down-regulation of ciramadol UDP-glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of ciramadol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234670", "aliases": ["down-regulation of bilirubin uridine diphosphoglucuronyltransferase activity", "downregulation of bilirubin uridine diphosphoglucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of bilirubin uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234671", "aliases": ["down-regulation of bilirubin UDPGT activity", "downregulation of bilirubin UDPGT activity"], "types": ["T044"], "canonical_name": "down regulation of bilirubin UDPGT activity"}
{"concept_id": "C4234672", "aliases": ["downregulation of bilirubin UDP-glucuronosyltransferase activity", "down-regulation of bilirubin UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of bilirubin UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234673", "aliases": ["downregulation of bilirubin monoglucuronide glucuronyltransferase activity", "down-regulation of bilirubin monoglucuronide glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of bilirubin monoglucuronide glucuronyltransferase activity"}
{"concept_id": "C4234674", "aliases": ["down-regulation of bilirubin glucuronyltransferase activity", "downregulation of bilirubin glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234675", "aliases": ["downregulation of 4-nitrophenol UDPGT activity", "down-regulation of 4-nitrophenol UDPGT activity"], "types": ["T044"], "canonical_name": "down regulation of 4-nitrophenol UDPGT activity"}
{"concept_id": "C4234676", "aliases": ["down-regulation of 4-nitrophenol UDP-glucuronyltransferase activity", "downregulation of 4-nitrophenol UDP-glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of 4-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234677", "aliases": ["downregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity", "down-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234678", "aliases": ["down-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity", "downregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234679", "aliases": ["downregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity", "down-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234680", "aliases": ["down-regulation of 3-OH androgenic UDPGT activity", "downregulation of 3-OH androgenic UDPGT activity"], "types": ["T044"], "canonical_name": "down regulation of 3-OH androgenic UDPGT activity"}
{"concept_id": "C4234681", "aliases": ["downregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity", "down-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234682", "aliases": ["downregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity", "down-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234683", "aliases": ["downregulation of 17-OH steroid UDPGT activity", "down-regulation of 17-OH steroid UDPGT activity"], "types": ["T044"], "canonical_name": "down regulation of 17-OH steroid UDPGT activity"}
{"concept_id": "C4234684", "aliases": ["down-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity", "downregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234685", "aliases": ["down-regulation of 1-naphthol-UDP-glucuronosyltransferase activity", "downregulation of 1-naphthol-UDP-glucuronosyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of 1-naphthol-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234686", "aliases": ["downregulation of 1-naphthol glucuronyltransferase activity", "down-regulation of 1-naphthol glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "down regulation of 1-naphthol glucuronyltransferase activity"}
{"concept_id": "C4234687", "aliases": [], "types": ["T044"], "canonical_name": "regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234688", "aliases": [], "types": ["T044"], "canonical_name": "regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234689", "aliases": [], "types": ["T044"], "canonical_name": "regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity"}
{"concept_id": "C4234690", "aliases": [], "types": ["T044"], "canonical_name": "regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity"}
{"concept_id": "C4234691", "aliases": [], "types": ["T044"], "canonical_name": "regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity"}
{"concept_id": "C4234692", "aliases": [], "types": ["T044"], "canonical_name": "regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity"}
{"concept_id": "C4234693", "aliases": [], "types": ["T044"], "canonical_name": "regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234694", "aliases": [], "types": ["T044"], "canonical_name": "regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity"}
{"concept_id": "C4234695", "aliases": [], "types": ["T044"], "canonical_name": "regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity"}
{"concept_id": "C4234696", "aliases": [], "types": ["T044"], "canonical_name": "regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234697", "aliases": [], "types": ["T044"], "canonical_name": "regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity"}
{"concept_id": "C4234698", "aliases": [], "types": ["T044"], "canonical_name": "regulation of UDP glucuronate-estriol glucuronosyltransferase activity"}
{"concept_id": "C4234699", "aliases": [], "types": ["T044"], "canonical_name": "regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity"}
{"concept_id": "C4234700", "aliases": [], "types": ["T044"], "canonical_name": "regulation of pnp-UDPGT activity"}
{"concept_id": "C4234701", "aliases": [], "types": ["T044"], "canonical_name": "regulation of PNP-UDPGT"}
{"concept_id": "C4234702", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phenyl-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234703", "aliases": [], "types": ["T044"], "canonical_name": "regulation of p-phenylphenol glucuronyltransferase activity"}
{"concept_id": "C4234704", "aliases": [], "types": ["T044"], "canonical_name": "regulation of p-nitrophenylglucuronosyltransferase activity"}
{"concept_id": "C4234705", "aliases": [], "types": ["T044"], "canonical_name": "regulation of p-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234706", "aliases": [], "types": ["T044"], "canonical_name": "regulation of p-nitrophenol UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234707", "aliases": [], "types": ["T044"], "canonical_name": "regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity"}
{"concept_id": "C4234708", "aliases": [], "types": ["T044"], "canonical_name": "regulation of morphine glucuronyltransferase activity"}
{"concept_id": "C4234709", "aliases": [], "types": ["T044"], "canonical_name": "regulation of estrone UDPglucuronosyltransferase activity"}
{"concept_id": "C4234710", "aliases": [], "types": ["T044"], "canonical_name": "regulation of estriol UDPglucuronosyltransferase activity"}
{"concept_id": "C4234711", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ciramadol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234712", "aliases": [], "types": ["T044"], "canonical_name": "regulation of bilirubin uridine diphosphoglucuronyltransferase activity"}
{"concept_id": "C4234713", "aliases": [], "types": ["T044"], "canonical_name": "regulation of bilirubin UDPGT activity"}
{"concept_id": "C4234714", "aliases": [], "types": ["T044"], "canonical_name": "regulation of bilirubin UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234715", "aliases": [], "types": ["T044"], "canonical_name": "regulation of bilirubin monoglucuronide glucuronyltransferase activity"}
{"concept_id": "C4234716", "aliases": [], "types": ["T044"], "canonical_name": "regulation of bilirubin glucuronyltransferase activity"}
{"concept_id": "C4234717", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 4-nitrophenol UDPGT activity"}
{"concept_id": "C4234718", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 4-nitrophenol UDP-glucuronyltransferase activity"}
{"concept_id": "C4234719", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234720", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234721", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234722", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 3-OH androgenic UDPGT activity"}
{"concept_id": "C4234723", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234724", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234725", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 17-OH steroid UDPGT activity"}
{"concept_id": "C4234726", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234727", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 1-naphthol-UDP-glucuronosyltransferase activity"}
{"concept_id": "C4234728", "aliases": [], "types": ["T044"], "canonical_name": "regulation of 1-naphthol glucuronyltransferase activity"}
{"concept_id": "C4234729", "aliases": ["upregulation of 3-oxosphinganine synthetase activity", "positive regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity", "positive regulation of SPT", "upregulation of serine C-palmitoyltransferase activity", "up regulation of serine C-palmitoyltransferase activity", "up-regulation of serine C-palmitoyltransferase activity", "up-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity", "up-regulation of 3-oxosphinganine synthetase activity", "up regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity", "up regulation of SPT", "positive regulation of 3-oxosphinganine synthetase activity", "up regulation of 3-oxosphinganine synthetase activity", "upregulation of SPT", "up-regulation of SPT", "upregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity"], "types": ["T044"], "canonical_name": "positive regulation of serine C-palmitoyltransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of serine C-palmitoyltransferase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]"}
{"concept_id": "C4234730", "aliases": ["upregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating", "up-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating"], "types": ["T044"], "canonical_name": "up regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating"}
{"concept_id": "C4234731", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating"}
{"concept_id": "C4234732", "aliases": [], "types": ["T044"], "canonical_name": "activation of SPT"}
{"concept_id": "C4234733", "aliases": [], "types": ["T044"], "canonical_name": "activation of serine C-palmitoyltransferase activity"}
{"concept_id": "C4234734", "aliases": [], "types": ["T044"], "canonical_name": "activation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity"}
{"concept_id": "C4234735", "aliases": [], "types": ["T044"], "canonical_name": "activation of acyl-CoA:serine C-2 acyltransferase decarboxylating"}
{"concept_id": "C4234736", "aliases": [], "types": ["T044"], "canonical_name": "activation of 3-oxosphinganine synthetase activity"}
{"concept_id": "C4234737", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of SPT"}
{"concept_id": "C4234738", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating"}
{"concept_id": "C4234739", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of SPT"}
{"concept_id": "C4234740", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of serine C-palmitoyltransferase activity"}
{"concept_id": "C4234741", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity"}
{"concept_id": "C4234742", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acyl-CoA:serine C-2 acyltransferase decarboxylating"}
{"concept_id": "C4234743", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 3-oxosphinganine synthetase activity"}
{"concept_id": "C4234744", "aliases": ["down-regulation of SPT", "downregulation of SPT"], "types": ["T044"], "canonical_name": "down regulation of SPT"}
{"concept_id": "C4234745", "aliases": ["downregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating", "down-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating"], "types": ["T044"], "canonical_name": "down regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating"}
{"concept_id": "C4234746", "aliases": [], "types": ["T044"], "canonical_name": "regulation of SPT"}
{"concept_id": "C4234747", "aliases": [], "types": ["T044"], "canonical_name": "regulation of serine palmitoyltransferase"}
{"concept_id": "C4234748", "aliases": [], "types": ["T044"], "canonical_name": "regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating"}
{"concept_id": "C4234749", "aliases": [], "types": ["T044"], "canonical_name": "activation of PS synthase activity"}
{"concept_id": "C4234750", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylserine synthetase activity"}
{"concept_id": "C4234751", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidylserine synthase activity"}
{"concept_id": "C4234752", "aliases": [], "types": ["T044"], "canonical_name": "activation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234753", "aliases": [], "types": ["T044"], "canonical_name": "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234754", "aliases": [], "types": ["T044"], "canonical_name": "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234755", "aliases": [], "types": ["T044"], "canonical_name": "activation of CDPdiglyceride-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234756", "aliases": [], "types": ["T044"], "canonical_name": "activation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234757", "aliases": [], "types": ["T044"], "canonical_name": "activation of CDP-diglycerine-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234758", "aliases": [], "types": ["T044"], "canonical_name": "activation of CDP-diglyceride:serine phosphatidyltransferase activity"}
{"concept_id": "C4234759", "aliases": [], "types": ["T044"], "canonical_name": "activation of CDP-diglyceride-L-serine phosphatidyltransferase activity"}
{"concept_id": "C4234760", "aliases": [], "types": ["T044"], "canonical_name": "activation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity"}
{"concept_id": "C4234761", "aliases": [], "types": ["T044"], "canonical_name": "activation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234762", "aliases": [], "types": ["T044"], "canonical_name": "activation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234763", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of PS synthase activity"}
{"concept_id": "C4234764", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylserine synthetase activity"}
{"concept_id": "C4234765", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidylserine synthase activity"}
{"concept_id": "C4234766", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234767", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234768", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234769", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CDPdiglyceride-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234770", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CDPdiacylglycerol-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234771", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CDP-diglycerine-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234772", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CDP-diglyceride:serine phosphatidyltransferase activity"}
{"concept_id": "C4234773", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CDP-diglyceride-L-serine phosphatidyltransferase activity"}
{"concept_id": "C4234774", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity"}
{"concept_id": "C4234775", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CDP-diacylglycerol-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234776", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity"}
{"concept_id": "C4234777", "aliases": [], "types": ["T044"], "canonical_name": "regulation of serine exchange enzyme"}
{"concept_id": "C4234778", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein transport into chloroplast stroma"}
{"concept_id": "C4234779", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein import into chloroplast stroma"}
{"concept_id": "C4234780", "aliases": [], "types": ["T043"], "canonical_name": "activation of chloroplast stroma protein import"}
{"concept_id": "C4234781", "aliases": [], "types": ["T043"], "canonical_name": "activation of iodide transmembrane transport"}
{"concept_id": "C4234782", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of iodide transmembrane transport"}
{"concept_id": "C4234783", "aliases": [], "types": ["T044"], "canonical_name": "intramembrane cleavage of ERAD substrate"}
{"concept_id": "C4234784", "aliases": [], "types": ["T044"], "canonical_name": "Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation"}
{"concept_id": "C4234785", "aliases": [], "types": ["T044"], "canonical_name": "Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly"}
{"concept_id": "C4234790", "aliases": [], "types": ["T039"], "canonical_name": "activation of skeletal muscle hypertrophy"}
{"concept_id": "C4234791", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of skeletal muscle hypertrophy"}
{"concept_id": "C4234792", "aliases": [], "types": ["T043"], "canonical_name": "activation of iodide transport"}
{"concept_id": "C4234793", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of iodide transport"}
{"concept_id": "C4234794", "aliases": [], "types": ["T043"], "canonical_name": "activation of regulation of vascular smooth muscle cell membrane depolarization"}
{"concept_id": "C4234795", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of regulation of vascular smooth muscle cell membrane depolarization"}
{"concept_id": "C4234796", "aliases": [], "types": ["T043"], "canonical_name": "activation of granulosa cell proliferation"}
{"concept_id": "C4234797", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of granulosa cell proliferation"}
{"concept_id": "C4234798", "aliases": ["up-regulation of epithelial cell of bile duct apoptosis", "upregulation of epithelial cell of bile duct apoptosis"], "types": ["T043"], "canonical_name": "up regulation of epithelial cell of bile duct apoptosis"}
{"concept_id": "C4234799", "aliases": ["up-regulation of cholangiocyte apoptosis", "upregulation of cholangiocyte apoptosis"], "types": ["T043"], "canonical_name": "up regulation of cholangiocyte apoptosis"}
{"concept_id": "C4234800", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of epithelial cell of bile duct apoptosis"}
{"concept_id": "C4234801", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cholangiocyte apoptosis"}
{"concept_id": "C4234802", "aliases": [], "types": ["T043"], "canonical_name": "activation of epithelial cell of bile duct apoptotic process"}
{"concept_id": "C4234803", "aliases": [], "types": ["T043"], "canonical_name": "activation of epithelial cell of bile duct apoptosis"}
{"concept_id": "C4234804", "aliases": [], "types": ["T043"], "canonical_name": "activation of cholangiocyte apoptotic process"}
{"concept_id": "C4234805", "aliases": [], "types": ["T043"], "canonical_name": "activation of cholangiocyte apoptosis"}
{"concept_id": "C4234806", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of epithelial cell of bile duct apoptosis"}
{"concept_id": "C4234807", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cholangiocyte apoptosis"}
{"concept_id": "C4234808", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of epithelial cell of bile duct apoptotic process"}
{"concept_id": "C4234809", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of epithelial cell of bile duct apoptosis"}
{"concept_id": "C4234810", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cholangiocyte apoptotic process"}
{"concept_id": "C4234811", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cholangiocyte apoptosis"}
{"concept_id": "C4234812", "aliases": ["down-regulation of epithelial cell of bile duct apoptosis", "downregulation of epithelial cell of bile duct apoptosis"], "types": ["T043"], "canonical_name": "down regulation of epithelial cell of bile duct apoptosis"}
{"concept_id": "C4234813", "aliases": ["downregulation of cholangiocyte apoptosis", "down-regulation of cholangiocyte apoptosis"], "types": ["T043"], "canonical_name": "down regulation of cholangiocyte apoptosis"}
{"concept_id": "C4234814", "aliases": [], "types": ["T043"], "canonical_name": "regulation of epithelial cell of bile duct apoptosis"}
{"concept_id": "C4234815", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cholangiocyte apoptosis"}
{"concept_id": "C4234816", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division"}
{"concept_id": "C4234817", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cyclin-dependent protein kinase activity involved in meiosis"}
{"concept_id": "C4234818", "aliases": [], "types": ["T043"], "canonical_name": "activation of cyclin-dependent protein kinase activity involved in meiotic nuclear division"}
{"concept_id": "C4234820", "aliases": [], "types": ["T038"], "canonical_name": "activation of viral transformation of host cell"}
{"concept_id": "C4234821", "aliases": [], "types": ["T038"], "canonical_name": "activation of viral transformation"}
{"concept_id": "C4234822", "aliases": [], "types": ["T038"], "canonical_name": "activation of transformation of host cell by virus"}
{"concept_id": "C4234823", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of viral transformation of host cell"}
{"concept_id": "C4234824", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of viral transformation"}
{"concept_id": "C4234825", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of transformation of host cell by virus"}
{"concept_id": "C4234826", "aliases": [], "types": ["T044"], "canonical_name": "activation of pyruvic dehydrogenase activity"}
{"concept_id": "C4234827", "aliases": [], "types": ["T044"], "canonical_name": "activation of pyruvic acid dehydrogenase activity"}
{"concept_id": "C4234828", "aliases": [], "types": ["T044"], "canonical_name": "activation of pyruvate dehydrogenase activity"}
{"concept_id": "C4234829", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pyruvic dehydrogenase activity"}
{"concept_id": "C4234830", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pyruvic acid dehydrogenase activity"}
{"concept_id": "C4234831", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of pyruvate dehydrogenase activity"}
{"concept_id": "C4234832", "aliases": [], "types": ["T043"], "canonical_name": "activation of membrane depolarization"}
{"concept_id": "C4234833", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of membrane depolarization"}
{"concept_id": "C4234834", "aliases": ["up-regulation of adipogenesis", "upregulation of adipogenesis"], "types": ["T039"], "canonical_name": "up regulation of adipogenesis"}
{"concept_id": "C4234835", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of adipogenesis"}
{"concept_id": "C4234836", "aliases": [], "types": ["T039"], "canonical_name": "activation of adipose tissue development"}
{"concept_id": "C4234837", "aliases": [], "types": ["T039"], "canonical_name": "activation of adipogenesis"}
{"concept_id": "C4234838", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of adipogenesis"}
{"concept_id": "C4234839", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of adipose tissue development"}
{"concept_id": "C4234840", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of adipogenesis"}
{"concept_id": "C4234841", "aliases": ["down-regulation of adipogenesis", "downregulation of adipogenesis"], "types": ["T039"], "canonical_name": "down regulation of adipogenesis"}
{"concept_id": "C4234842", "aliases": [], "types": ["T038"], "canonical_name": "regulation of adipogenesis"}
{"concept_id": "C4234843", "aliases": [], "types": ["T044"], "canonical_name": "activation of histone demethylase activity (H3-K4 specific)"}
{"concept_id": "C4234844", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone demethylase activity (H3-K4 specific)"}
{"concept_id": "C4234845", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell blebbing"}
{"concept_id": "C4234846", "aliases": [], "types": ["T043"], "canonical_name": "activation of bleb assembly"}
{"concept_id": "C4234847", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell blebbing"}
{"concept_id": "C4234848", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of bleb assembly"}
{"concept_id": "C4234853", "aliases": [], "types": ["T045"], "canonical_name": "mitotic DNA repair synthesis involved in UVER"}
{"concept_id": "C4234854", "aliases": [], "types": ["T045"], "canonical_name": "mitotic DNA repair synthesis involved in UVDE-dependent excision repair"}
{"concept_id": "C4234855", "aliases": [], "types": ["T045"], "canonical_name": "mitotic DNA repair synthesis involved in UV-damaged DNA endonuclease-dependent excision repair"}
{"concept_id": "C4234856", "aliases": [], "types": ["T045"], "canonical_name": "mitotic DNA repair synthesis involved in UV-damage excision repair"}
{"concept_id": "C4234857", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis involved in alternative excision repair"}
{"concept_id": "C4234858", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis involved in AER"}
{"concept_id": "C4234859", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis during UVER"}
{"concept_id": "C4234860", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis during UVDE-dependent excision repair"}
{"concept_id": "C4234861", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis during UV-damaged DNA endonuclease-dependent excision repair"}
{"concept_id": "C4234862", "aliases": [], "types": ["T045"], "canonical_name": "DNA synthesis during UV-damage excision repair"}
{"concept_id": "C4234863", "aliases": [], "types": ["T043"], "canonical_name": "activation of retrograde protein transport, ER to cytosol"}
{"concept_id": "C4234864", "aliases": [], "types": ["T043"], "canonical_name": "activation of retrograde protein transport, endoplasmic reticulum to cytosol"}
{"concept_id": "C4234865", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein dislocation from ER"}
{"concept_id": "C4234866", "aliases": ["downregulation of protein dislocation from ER", "down regulation of retrograde protein transport, ER to cytosol", "downregulation of retrograde protein transport, endoplasmic reticulum to cytosol", "negative regulation of protein dislocation from ER", "down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol", "down-regulation of protein dislocation from ER", "negative regulation of protein retrotranslocation from ER", "down regulation of retrograde protein transport, endoplasmic reticulum to cytosol", "downregulation of retrograde protein transport, ER to cytosol", "negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol", "inhibition of retrograde protein transport, ER to cytosol", "down regulation of protein dislocation from ER", "down-regulation of retrograde protein transport, ER to cytosol"], "types": ["T043"], "canonical_name": "negative regulation of retrograde protein transport, ER to cytosol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]"}
{"concept_id": "C4234867", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of retrograde protein transport, endoplasmic reticulum to cytosol"}
{"concept_id": "C4234868", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein dislocation from ER"}
{"concept_id": "C4234869", "aliases": [], "types": ["T043"], "canonical_name": "activation of microglial cell mediated cytotoxicity"}
{"concept_id": "C4234870", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microglial cell mediated cytotoxicity"}
{"concept_id": "C4234871", "aliases": [], "types": ["T044"], "canonical_name": "activation of meiotic cell cycle process involved in oocyte maturation"}
{"concept_id": "C4234872", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of meiotic cell cycle process involved in oocyte maturation"}
{"concept_id": "C4234873", "aliases": [], "types": ["T044"], "canonical_name": "activation of carotenoid synthesis"}
{"concept_id": "C4234874", "aliases": [], "types": ["T044"], "canonical_name": "activation of carotenoid formation"}
{"concept_id": "C4234875", "aliases": [], "types": ["T044"], "canonical_name": "activation of carotenoid biosynthetic process"}
{"concept_id": "C4234876", "aliases": ["activation of carotenoid biosynthesis", "up-regulation of carotenoid formation", "upregulation of carotenoid biosynthetic process", "positive regulation of carotenoid anabolism", "up regulation of carotenoid biosynthesis", "upregulation of carotenoid anabolism", "positive regulation of carotenoid formation", "up regulation of carotenoid synthesis", "up-regulation of carotenoid biosynthesis", "up regulation of carotenoid biosynthetic process", "up-regulation of carotenoid anabolism", "upregulation of carotenoid formation", "up-regulation of carotenoid biosynthetic process", "up regulation of carotenoid formation", "upregulation of carotenoid biosynthesis", "positive regulation of carotenoid biosynthesis", "upregulation of carotenoid synthesis", "up-regulation of carotenoid synthesis", "up regulation of carotenoid anabolism", "positive regulation of carotenoid synthesis"], "types": ["T044"], "canonical_name": "positive regulation of carotenoid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of carotenoid biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:25675505]"}
{"concept_id": "C4234877", "aliases": [], "types": ["T044"], "canonical_name": "activation of carotenoid anabolism"}
{"concept_id": "C4234878", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carotenoid synthesis"}
{"concept_id": "C4234879", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carotenoid formation"}
{"concept_id": "C4234880", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carotenoid biosynthetic process"}
{"concept_id": "C4234881", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carotenoid biosynthesis"}
{"concept_id": "C4234882", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of carotenoid anabolism"}
{"concept_id": "C4234883", "aliases": [], "types": ["T043"], "canonical_name": "activation of microglial cell migration"}
{"concept_id": "C4234884", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microglial cell migration"}
{"concept_id": "C4234885", "aliases": [], "types": ["T040"], "canonical_name": "activation of convergent extension involved in notochord morphogenesis"}
{"concept_id": "C4234886", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of convergent extension involved in notochord morphogenesis"}
{"concept_id": "C4234887", "aliases": [], "types": ["T039"], "canonical_name": "activation of convergent extension involved in rhombomere morphogenesis"}
{"concept_id": "C4234888", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of convergent extension involved in rhombomere morphogenesis"}
{"concept_id": "C4234889", "aliases": [], "types": ["T042"], "canonical_name": "activation of convergent extension involved in neural plate elongation"}
{"concept_id": "C4234890", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of convergent extension involved in neural plate elongation"}
{"concept_id": "C4234891", "aliases": [], "types": ["T042"], "canonical_name": "activation of convergent extension involved in somitogenesis"}
{"concept_id": "C4234892", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of convergent extension involved in somitogenesis"}
{"concept_id": "C4234893", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of fatty acid beta-oxidation by serotonin receptor signaling pathway"}
{"concept_id": "C4234894", "aliases": [], "types": ["T044"], "canonical_name": "activation of fatty acid beta-oxidation by serotonin receptor signaling pathway"}
{"concept_id": "C4234895", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of fatty acid beta-oxidation by octopamine signaling pathway"}
{"concept_id": "C4234896", "aliases": [], "types": ["T043"], "canonical_name": "activation of fatty acid beta-oxidation by octopamine signaling pathway"}
{"concept_id": "C4234897", "aliases": [], "types": ["T040"], "canonical_name": "activation of otic vesicle morphogenesis"}
{"concept_id": "C4234898", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of otic vesicle morphogenesis"}
{"concept_id": "C4234899", "aliases": [], "types": ["T043"], "canonical_name": "activation of muscle filament sliding"}
{"concept_id": "C4234900", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of muscle filament sliding"}
{"concept_id": "C4234912", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of EIF2AK3-mediated unfolded protein response"}
{"concept_id": "C4234913", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of EIF2AK3-mediated unfolded protein response"}
{"concept_id": "C4234914", "aliases": [], "types": ["T044"], "canonical_name": "regulation of EIF2AK3-mediated unfolded protein response"}
{"concept_id": "C4234915", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ERN1-mediated unfolded protein response"}
{"concept_id": "C4234916", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ERN1-mediated unfolded protein response"}
{"concept_id": "C4234917", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ERN1-mediated unfolded protein response"}
{"concept_id": "C4234922", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial degradation"}
{"concept_id": "C4234923", "aliases": ["down-regulation of mitochondrion degradation", "downregulation of mitochondrion degradation"], "types": ["T043"], "canonical_name": "down regulation of mitochondrion degradation"}
{"concept_id": "C4234924", "aliases": [], "types": ["T043"], "canonical_name": "down regulation of mitochondrial degradation"}
{"concept_id": "C4234925", "aliases": ["metalloendoproteinase activity involved in amyloid precursor protein catabolic process", "metalloendoproteinase activity involved in amyloid precursor protein catabolism", "metalloendoproteinase activity involved in APP catabolism"], "types": ["T044"], "canonical_name": "metalloendoproteinase activity involved in APP catabolic process"}
{"concept_id": "C4234926", "aliases": [], "types": ["T044"], "canonical_name": "metalloendoproteinase activity involved in amyloid precursor protein degradation"}
{"concept_id": "C4234927", "aliases": [], "types": ["T044"], "canonical_name": "metalloendoproteinase activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C4234928", "aliases": ["metalloendoprotease activity involved in amyloid precursor protein catabolism", "metalloendoprotease activity involved in APP catabolism", "metalloendoprotease activity involved in amyloid precursor protein catabolic process"], "types": ["T044"], "canonical_name": "metalloendoprotease activity involved in APP catabolic process"}
{"concept_id": "C4234929", "aliases": [], "types": ["T044"], "canonical_name": "metalloendoprotease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C4234930", "aliases": [], "types": ["T044"], "canonical_name": "metalloendoprotease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C4234931", "aliases": ["carboxyl protease activity involved in amyloid precursor protein catabolic process", "carboxyl protease activity involved in amyloid precursor protein catabolism", "carboxyl protease activity involved in APP catabolism"], "types": ["T044"], "canonical_name": "carboxyl protease activity involved in APP catabolic process"}
{"concept_id": "C4234932", "aliases": [], "types": ["T044"], "canonical_name": "carboxyl protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C4234933", "aliases": [], "types": ["T044"], "canonical_name": "carboxyl protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C4234934", "aliases": ["aspartyl protease activity involved in APP catabolism", "aspartyl protease activity involved in amyloid precursor protein catabolism", "aspartyl protease activity involved in amyloid precursor protein catabolic process"], "types": ["T044"], "canonical_name": "aspartyl protease activity involved in APP catabolic process"}
{"concept_id": "C4234935", "aliases": [], "types": ["T044"], "canonical_name": "aspartyl protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C4234936", "aliases": [], "types": ["T044"], "canonical_name": "aspartyl protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C4234937", "aliases": ["aspartic protease activity involved in APP catabolism", "aspartic protease activity involved in amyloid precursor protein catabolic process", "aspartic protease activity involved in amyloid precursor protein catabolism"], "types": ["T044"], "canonical_name": "aspartic protease activity involved in APP catabolic process"}
{"concept_id": "C4234938", "aliases": [], "types": ["T044"], "canonical_name": "aspartic protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C4234939", "aliases": [], "types": ["T044"], "canonical_name": "aspartic protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C4234940", "aliases": ["aspartate protease activity involved in amyloid precursor protein catabolism", "aspartate protease activity involved in APP catabolism", "aspartate protease activity involved in amyloid precursor protein catabolic process"], "types": ["T044"], "canonical_name": "aspartate protease activity involved in APP catabolic process"}
{"concept_id": "C4234941", "aliases": [], "types": ["T044"], "canonical_name": "aspartate protease activity involved in amyloid precursor protein degradation"}
{"concept_id": "C4234942", "aliases": [], "types": ["T044"], "canonical_name": "aspartate protease activity involved in amyloid precursor protein breakdown"}
{"concept_id": "C4234943", "aliases": ["up-regulation of serine protease activity", "upregulation of serine protease activity"], "types": ["T044"], "canonical_name": "up regulation of serine protease activity"}
{"concept_id": "C4234944", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of serine protease activity"}
{"concept_id": "C4234945", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of serine protease activity"}
{"concept_id": "C4234946", "aliases": ["down-regulation of serine protease activity", "downregulation of serine protease activity"], "types": ["T044"], "canonical_name": "down regulation of serine protease activity"}
{"concept_id": "C4234947", "aliases": [], "types": ["T026"], "canonical_name": "ficolin granule"}
{"concept_id": "C4234948", "aliases": [], "types": ["T043"], "canonical_name": "axonal protein transport"}
{"concept_id": "C4234949", "aliases": [], "types": ["T043"], "canonical_name": "heart repolarization"}
{"concept_id": "C4234950", "aliases": [], "types": ["T044"], "canonical_name": "regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering"}
{"concept_id": "C4234952", "aliases": [], "types": ["T044"], "canonical_name": "nuclear rRNA polyadenylation involved in poly(A)-dependent rRNA catabolic process"}
{"concept_id": "C4234953", "aliases": [], "types": ["T044"], "canonical_name": "nuclear rRNA polyadenylation during polyadenylation-dependent rRNA catabolic process"}
{"concept_id": "C4234955", "aliases": [], "types": ["T045"], "canonical_name": "pasRNA transcription"}
{"concept_id": "C4234956", "aliases": [], "types": ["T043"], "canonical_name": "iron-dependent programmed cell death"}
{"concept_id": "C4234957", "aliases": [], "types": ["T045"], "canonical_name": "TERRA RNA transcription from RNA pol II promoter"}
{"concept_id": "C4234958", "aliases": [], "types": ["T026"], "canonical_name": "apoptotic bleb"}
{"concept_id": "C4234959", "aliases": [], "types": ["T044"], "canonical_name": "generation of T-type calcium current"}
{"concept_id": "C4234960", "aliases": ["galanin signalling pathway"], "types": ["T043"], "canonical_name": "galanin signaling pathway"}
{"concept_id": "C4234961", "aliases": [], "types": ["T040"], "canonical_name": "locomotor gait pattern"}
{"concept_id": "C4234962", "aliases": [], "types": ["T038"], "canonical_name": "response to the introduction of novel objects"}
{"concept_id": "C4234963", "aliases": [], "types": ["T040"], "canonical_name": "senescence-induced resistance"}
{"concept_id": "C4234964", "aliases": [], "types": ["T040"], "canonical_name": "ontogenic resistance"}
{"concept_id": "C4234965", "aliases": [], "types": ["T038"], "canonical_name": "mature seedling resistance"}
{"concept_id": "C4234966", "aliases": [], "types": ["T040"], "canonical_name": "flowering-induced resistance"}
{"concept_id": "C4234967", "aliases": [], "types": ["T040"], "canonical_name": "developmental resistance"}
{"concept_id": "C4234968", "aliases": [], "types": ["T038"], "canonical_name": "adult seedling resistance"}
{"concept_id": "C4234969", "aliases": [], "types": ["T045"], "canonical_name": "rabl configuration"}
{"concept_id": "C4234970", "aliases": [], "types": ["T042"], "canonical_name": "Wolffian duct morphogenesis"}
{"concept_id": "C4234971", "aliases": ["BAT3-TRC35-UBL4A complex location"], "types": ["T026"], "canonical_name": "BAT3-TRC35-UBL4A complex"}
{"concept_id": "C4234972", "aliases": [], "types": ["T045"], "canonical_name": "alternative excision repair"}
{"concept_id": "C4234974", "aliases": ["PARP-dependent cell death"], "types": ["T043"], "definition": "A type of regulated cell death initiated by hyperactivation of POLY (ADP-RIBOSE) POLYMERASE-1 (PARP-1) as a consequence of DNA DAMAGE; OXIDATIVE STRESS; HYPOXIA; HYPOGLYCEMIA; or INFLAMMATION. This leads to DNA FRAGMENTATION and CHROMATIN condensation.", "canonical_name": "parthanatos"}
{"concept_id": "C4234979", "aliases": [], "types": ["T045"], "canonical_name": "TERC binding"}
{"concept_id": "C4234980", "aliases": [], "types": ["T038"], "canonical_name": "stress-activated AMP-activated protein kinase signaling cascade"}
{"concept_id": "C4234981", "aliases": [], "types": ["T044"], "canonical_name": "D-2HG reductase activity"}
{"concept_id": "C4234982", "aliases": [], "types": ["T044"], "canonical_name": "2-oxoglutarate reductase activity"}
{"concept_id": "C4234983", "aliases": [], "types": ["T044"], "canonical_name": "2-ketoglutarate reductase activity"}
{"concept_id": "C4234984", "aliases": [], "types": ["T044"], "canonical_name": "acid SMase"}
{"concept_id": "C4234985", "aliases": ["CMA receptor complex location"], "types": ["T026"], "canonical_name": "CMA receptor complex"}
{"concept_id": "C4234986", "aliases": ["chaperone-mediated autophagy receptor complex location"], "types": ["T026"], "canonical_name": "chaperone-mediated autophagy receptor complex"}
{"concept_id": "C4234987", "aliases": [], "types": ["T044"], "canonical_name": "nucleoside diphosphate reductase activity"}
{"concept_id": "C4234988", "aliases": [], "types": ["T044"], "canonical_name": "class III ribonucleotide reductase activity"}
{"concept_id": "C4234989", "aliases": [], "types": ["T044"], "canonical_name": "class II ribonucleotide reductase activity"}
{"concept_id": "C4234990", "aliases": [], "types": ["T044"], "canonical_name": "class II ribonucleoside-diphosphate reductase activity"}
{"concept_id": "C4234991", "aliases": [], "types": ["T044"], "canonical_name": "class I ribonucleotide reductase activity"}
{"concept_id": "C4234992", "aliases": [], "types": ["T044"], "canonical_name": "anaerobic iron-sulfur-dependent ribonucleotide reductase activity"}
{"concept_id": "C4234993", "aliases": [], "types": ["T044"], "canonical_name": "aerobic non-heme iron-dependent ribonucleotide reductase activity"}
{"concept_id": "C4234994", "aliases": [], "types": ["T044"], "canonical_name": "adenosylcobalamin-dependent ribonucleotide reductase activity"}
{"concept_id": "C4234995", "aliases": [], "types": ["T043"], "canonical_name": "ER degradation"}
{"concept_id": "C4234996", "aliases": [], "types": ["T043"], "canonical_name": "endoplasmic reticulum degradation"}
{"concept_id": "C4234997", "aliases": [], "types": ["T043"], "canonical_name": "cardiocyte cell fate determination"}
{"concept_id": "C4234998", "aliases": [], "types": ["T042"], "canonical_name": "histolysis"}
{"concept_id": "C4235005", "aliases": [], "types": ["T026"], "canonical_name": "regulation of adhesion plaque assembly"}
{"concept_id": "C4235006", "aliases": [], "types": ["T043"], "canonical_name": "autosis"}
{"concept_id": "C4235007", "aliases": [], "types": ["T043"], "canonical_name": "adhesion plaque assembly"}
{"concept_id": "C4235008", "aliases": ["CoQH2-cytochrome c reductase complex location"], "types": ["T026"], "canonical_name": "CoQH2-cytochrome c reductase complex"}
{"concept_id": "C4235009", "aliases": [], "types": ["T043"], "canonical_name": "defective cytokinesis checkpoint"}
{"concept_id": "C4235010", "aliases": ["axonal shaft"], "types": ["T026"], "canonical_name": "axon shaft", "definition": "OBSOLETE. Main portion of an axon, excluding terminal, spines, or dendrites. [PMID:11264310, PMID:24312009]"}
{"concept_id": "C4235011", "aliases": ["upregulation of metalloenzyme activity", "up-regulation of metalloenzyme activity"], "types": ["T044"], "canonical_name": "up regulation of metalloenzyme activity"}
{"concept_id": "C4235012", "aliases": [], "types": ["T043"], "canonical_name": "midbrain dopaminergic neuron-astrocyte crosstalk"}
{"concept_id": "C4235013", "aliases": [], "types": ["T043"], "canonical_name": "mesencephalic dopaminergic neuron-astrocyte crosstalk"}
{"concept_id": "C4235014", "aliases": [], "types": ["T043"], "canonical_name": "dopaminergic neuron-astrocyte crosstalk"}
{"concept_id": "C4235015", "aliases": [], "types": ["T043"], "canonical_name": "chemorepulsion of serotonergic axon"}
{"concept_id": "C4235016", "aliases": ["glycoprotein mannose trimming on A branch"], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming on A branch"}
{"concept_id": "C4235017", "aliases": [], "types": ["T044"], "canonical_name": "conversion of M8A to M7AA"}
{"concept_id": "C4235018", "aliases": [], "types": ["T044"], "canonical_name": "conversion of (Man)8A(GlcNAc)2 to (Man)7AA(GlcNAc)2"}
{"concept_id": "C4235019", "aliases": [], "types": ["T044"], "canonical_name": "conversion of M9 to M8A"}
{"concept_id": "C4235020", "aliases": [], "types": ["T044"], "canonical_name": "conversion of (Man)9(GlcNAc)2 to (Man)8A(GlcNAc)2"}
{"concept_id": "C4235021", "aliases": [], "types": ["T044"], "canonical_name": "conversion of M9 to M8C"}
{"concept_id": "C4235022", "aliases": [], "types": ["T044"], "canonical_name": "conversion of (Man)9(GlcNAc)2 to (Man)8C(GlcNAc)2"}
{"concept_id": "C4235023", "aliases": [], "types": ["T044"], "canonical_name": "conversion of M9 to M8B"}
{"concept_id": "C4235024", "aliases": [], "types": ["T044"], "canonical_name": "conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2"}
{"concept_id": "C4235025", "aliases": [], "types": ["T044"], "canonical_name": "mannose trimming"}
{"concept_id": "C4235026", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein mannose trimming"}
{"concept_id": "C4235027", "aliases": [], "types": ["T043"], "canonical_name": "ER-associated degradation pathway"}
{"concept_id": "C4235028", "aliases": [], "types": ["T043"], "canonical_name": "endoplasmic reticulum-associated protein degradation pathway"}
{"concept_id": "C4235029", "aliases": [], "types": ["T044"], "canonical_name": "eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response"}
{"concept_id": "C4235030", "aliases": [], "types": ["T044"], "canonical_name": "EIF2AK3-mediated unfolded protein response"}
{"concept_id": "C4235031", "aliases": [], "types": ["T044"], "canonical_name": "inositol-requiring enzyme 1-mediated unfolded protein response"}
{"concept_id": "C4235032", "aliases": [], "types": ["T044"], "canonical_name": "ERN1-mediated unfolded protein response"}
{"concept_id": "C4235033", "aliases": ["response to hydroxymethylglutaryl-CoA reductase inhibitor"], "types": ["T040"], "canonical_name": "response to HMG-CoA reductase inhibitor"}
{"concept_id": "C4235036", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to restraint stress"}
{"concept_id": "C4235037", "aliases": [], "types": ["T039"], "canonical_name": "response to restraint stress"}
{"concept_id": "C4235038", "aliases": [], "types": ["T044"], "canonical_name": "inositol 4-phosphatase"}
{"concept_id": "C4235039", "aliases": [], "types": ["T044"], "canonical_name": "Leloir Pathway"}
{"concept_id": "C4235040", "aliases": [], "types": ["T043"], "canonical_name": "membrane blebbing"}
{"concept_id": "C4235041", "aliases": [], "types": ["T043"], "canonical_name": "blebbing"}
{"concept_id": "C4235042", "aliases": ["SNF1/AMPK protein kinase complex location"], "types": ["T026"], "canonical_name": "SNF1/AMPK protein kinase complex"}
{"concept_id": "C4235043", "aliases": ["ADP-activated protein kinase complex location"], "types": ["T026"], "canonical_name": "ADP-activated protein kinase complex"}
{"concept_id": "C4235044", "aliases": [], "types": ["T026"], "canonical_name": "gas vacuole"}
{"concept_id": "C4235049", "aliases": [], "types": ["T038"], "canonical_name": "corticogenesis"}
{"concept_id": "C4235050", "aliases": [], "types": ["T044"], "canonical_name": "glucose catabolic process to mixed acids"}
{"concept_id": "C4235051", "aliases": [], "types": ["T044"], "canonical_name": "methylglyoxal degradation to D-lactate"}
{"concept_id": "C4235052", "aliases": [], "types": ["T044"], "canonical_name": "methylglyoxal breakdown to D-lactate"}
{"concept_id": "C4235053", "aliases": ["D-lactate biosynthetic process from methylglyoxal"], "types": ["T044"], "canonical_name": "D-lactate biosynthesis from methylglyoxal"}
{"concept_id": "C4235054", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organism reproductive behavior"}
{"concept_id": "C4235055", "aliases": [], "types": ["T043"], "canonical_name": "caspase-dependent programmed cell death"}
{"concept_id": "C4235056", "aliases": [], "types": ["T044"], "canonical_name": "non-selective cation channel activity"}
{"concept_id": "C4235057", "aliases": [], "types": ["T044"], "canonical_name": "non-selective anion channel activity"}
{"concept_id": "C4235058", "aliases": [], "types": ["T044"], "canonical_name": "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity"}
{"concept_id": "C4235059", "aliases": [], "types": ["T044"], "canonical_name": "proline, 2-oxoglutarate dioxygenase activity"}
{"concept_id": "C4235060", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl proline hydroxylase activity"}
{"concept_id": "C4235061", "aliases": [], "types": ["T044"], "canonical_name": "mannose-9 processing alpha-mannosidase activity"}
{"concept_id": "C4235062", "aliases": [], "types": ["T044"], "canonical_name": "carboxyl protease activity"}
{"concept_id": "C4235063", "aliases": [], "types": ["T044"], "canonical_name": "aspartyl protease activity"}
{"concept_id": "C4235064", "aliases": [], "types": ["T044"], "canonical_name": "aspartic protease activity"}
{"concept_id": "C4235065", "aliases": [], "types": ["T044"], "canonical_name": "aspartate protease activity"}
{"concept_id": "C4235066", "aliases": [], "types": ["T043"], "canonical_name": "response to sustained hypoxia", "definition": "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sustained stimulus indicating lowered oxygen tension. [PMID:24055447]"}
{"concept_id": "C4235067", "aliases": [], "types": ["T043"], "canonical_name": "response to intermittent hypoxia", "definition": "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an episodic stimulus indicating lowered oxygen tension. [PMID:24055447]"}
{"concept_id": "C4235068", "aliases": ["HRD1 ubiquitin ligase complex location"], "types": ["T026"], "canonical_name": "HRD1 ubiquitin ligase complex"}
{"concept_id": "C4235070", "aliases": [], "types": ["T043"], "canonical_name": "proteasome localization to nuclear periphery", "definition": "Any process in which the proteasome is transported to, or maintained at the nuclear periphery. [PMID:11084332]"}
{"concept_id": "C4235073", "aliases": ["ligand-gated ion channel signalling pathway"], "types": ["T044"], "canonical_name": "ligand-gated ion channel signaling pathway", "definition": "The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription. [GOC:bhm, PMID:25869137]"}
{"concept_id": "C4235091", "aliases": ["PET complex location"], "types": ["T026"], "canonical_name": "PET complex", "definition": "A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs. [PMID:26669262]"}
{"concept_id": "C4235092", "aliases": ["beta-catenin-TCF complex location"], "types": ["T026"], "canonical_name": "beta-catenin-TCF complex", "definition": "A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]"}
{"concept_id": "C4235094", "aliases": ["CST complex location"], "types": ["T026"], "definition": "A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19854130, PMID:22965356]", "canonical_name": "CST complex"}
{"concept_id": "C4235095", "aliases": ["FLCN-FNIP1 complex", "BFC complex", "FLCN-FNIP1 complex location", "FLCN-FNIP2 complex", "Lst4-Lst7 complex", "FLCN-FNIP2 complex location", "FNIP-Folliculin RagC/D GAP complex", "FNIP-Folliculin RagC/D GAP complex location", "BFC complex location", "Lst4-Lst7 complex location"], "types": ["T026"], "canonical_name": "FNIP-folliculin RagC/D GAP", "definition": "A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2. [GOC:rn, PMID:24095279, PMID:26387955, PMID:34805795]"}
{"concept_id": "C4235096", "aliases": ["Vma12-Vma22 assembly complex location"], "types": ["T026"], "canonical_name": "Vma12-Vma22 assembly complex", "definition": "A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p. [GOC:rb, PMID:9660861]"}
{"concept_id": "C4235097", "aliases": ["nuclear membrane complex Bqt3-Bqt4 location"], "types": ["T026"], "canonical_name": "nuclear membrane complex Bqt3-Bqt4", "definition": "A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4. [PMID:19948484]"}
{"concept_id": "C4235098", "aliases": ["Ubp3-Bre5 ubiquitin protease complex", "Ubp3-Bre5 deubiquitination complex location", "Ubp3-Bre5 ubiquitin protease complex location"], "types": ["T026"], "canonical_name": "Ubp3-Bre5 deubiquitination complex", "definition": "A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p. [GOC:rb, PMID:12778054, PMID:18391941]"}
{"concept_id": "C4235099", "aliases": ["Pho85-Pho80 CDK-cyclin complex location"], "types": ["T026"], "canonical_name": "Pho85-Pho80 CDK-cyclin complex", "definition": "A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin. [GOC:rb, PMID:8108735]"}
{"concept_id": "C4235101", "aliases": ["Wnt.Fz.LRP ternary complex location", "Wnt-Frizzled-LRP5/6 complex location", "Wnt-FZD-LRP5/6 trimeric complex location", "Wnt-FZD-LRP5/6 trimeric complex", "Wnt.Fz.LRP ternary complex"], "types": ["T026"], "canonical_name": "Wnt-Frizzled-LRP5/6 complex", "definition": "A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6. [GOC:bf, GOC:PARL, PMID:11448771, PMID:20093360]"}
{"concept_id": "C4235102", "aliases": ["H-gal-GP complex location", "Haemonchus galactose-containing glycoprotein complex location", "Haemonchus galactose-containing glycoprotein complex"], "types": ["T026"], "canonical_name": "H-gal-GP complex", "definition": "A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus. [PMID:11166393]"}
{"concept_id": "C4235103", "aliases": ["nucleoplasmic periphery of the nuclear pore complex location"], "types": ["T026"], "canonical_name": "nucleoplasmic periphery of the nuclear pore complex", "definition": "Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex. [PMID:10633080]"}
{"concept_id": "C4235104", "aliases": ["Msd1-Wdr8-Pkl1 complex location", "Msd1-Wdr8-Pkl1 complex", "MWP complex location"], "types": ["T026"], "canonical_name": "MWP complex", "definition": "A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin. [PMID:25987607, PMID:29021344]"}
{"concept_id": "C4235105", "aliases": ["GLI-SUFU complex location"], "types": ["T026"], "canonical_name": "GLI-SUFU complex", "definition": "A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins. [GOC:bhm, PMID:24311597]"}
{"concept_id": "C4235108", "aliases": ["EARP complex location"], "types": ["T026"], "canonical_name": "EARP complex", "definition": "A quatrefoil tethering complex required for endocytic recycling. [PMID:25799061]"}
{"concept_id": "C4235109", "aliases": ["titin-telethonin complex location"], "types": ["T026"], "canonical_name": "titin-telethonin complex", "definition": "A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils. [GOC:ame, PMID:16407954]"}
{"concept_id": "C4235110", "aliases": ["p97-p47 complex", "VCP-NSFL1C complex location", "p97-p47 complex location"], "types": ["T026"], "canonical_name": "VCP-NSFL1C complex", "definition": "A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97. [GOC:bf, GOC:PARL, PMID:9214505]"}
{"concept_id": "C4235111", "aliases": ["mitotic spindle assembly checkpoint MAD1-MAD2 complex location", "MAD1-MAD2 complex location", "MAD1-MAD2 complex"], "types": ["T026"], "canonical_name": "mitotic spindle assembly checkpoint MAD1-MAD2 complex", "definition": "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex. [GOC:bhm, PMID:12006501, PMID:22898774]"}
{"concept_id": "C4235112", "aliases": ["tubulin folding cofactor complex location"], "types": ["T026"], "canonical_name": "tubulin folding cofactor complex", "definition": "A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur. [GOC:vw, PMID:12445400]"}
{"concept_id": "C4235113", "aliases": ["Lsm1-7-Pat1 complex location"], "types": ["T026"], "canonical_name": "Lsm1-7-Pat1 complex", "definition": "A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway. [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202]"}
{"concept_id": "C4235114", "aliases": ["galectin complex location"], "types": ["T026"], "canonical_name": "galectin complex", "definition": "A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes. [GOC:bhm, PMID:15476813, PMID:18777589, PMID:8262940]"}
{"concept_id": "C4235115", "aliases": ["cytoplasmic periphery of the nuclear pore complex location"], "types": ["T026"], "canonical_name": "cytoplasmic periphery of the nuclear pore complex", "definition": "Cytoplasm situated in close proximity to a nuclear pore complex. [PMID:9398662]"}
{"concept_id": "C4235116", "aliases": ["DAPK1-calmodulin complex location", "death-associated protein kinase 1 - calmodulin complex location", "death-associated protein kinase 1 - calmodulin complex"], "types": ["T026"], "canonical_name": "DAPK1-calmodulin complex", "definition": "A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding. [GOC:bhm, PMID:20103772]"}
{"concept_id": "C4235117", "aliases": ["PKM2 protein kinase complex location"], "types": ["T026"], "canonical_name": "PKM2 protein kinase complex", "definition": "A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer. [GOC:bhm, PMID:24606918]"}
{"concept_id": "C4235118", "aliases": ["HEPS complex", "heparanase complex location", "HEPS complex location"], "types": ["T026"], "canonical_name": "heparanase complex", "definition": "A protein complex which is capable of heparanase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12927802]"}
{"concept_id": "C4235119", "aliases": ["ATPase complex location"], "types": ["T026"], "canonical_name": "ATPase complex", "definition": "A protein complex which is capable of ATPase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181]"}
{"concept_id": "C4235120", "aliases": ["trimethylamine-N-oxide reductase (cytochrome c) complex location"], "types": ["T026"], "canonical_name": "trimethylamine-N-oxide reductase (cytochrome c) complex", "definition": "A protein complex which is capable of trimethylamine-N-oxide reductase (cytochrome c) activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11056172]"}
{"concept_id": "C4235121", "aliases": ["5HT3 receptor complex location", "5-hydroxytryptamine receptor 3 complex", "serotonin-activated cation-selective channel complex location", "5-HT3 receptor complex location", "5-HT-3 receptor complex location", "5-HT3 receptor complex", "5-hydroxytryptamine receptor 3 complex location", "5HT3 receptor complex", "5-HT-3 receptor complex"], "types": ["T026"], "canonical_name": "serotonin-activated cation-selective channel complex", "definition": "A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]"}
{"concept_id": "C4235122", "aliases": ["Nbp35-Cfd1 ATPase complex location"], "types": ["T026"], "canonical_name": "Nbp35-Cfd1 ATPase complex", "definition": "An iron-sulfur cluster assembly complex that is capable of weak ATPase activity. In yeast it consists of two subunits, Nbp35 and Cfd1. [GO_REF:0000088, GOC:bhm, GOC:rb, GOC:TermGenie, PMID:26195633]"}
{"concept_id": "C4235123", "aliases": ["dehydrodolichyl diphosphate synthase complex location"], "types": ["T026"], "canonical_name": "dehydrodolichyl diphosphate synthase complex", "definition": "A protein complex which is capable of dehydrodolichyl diphosphate synthase activity. [GO_REF:0000088, GOC:TermGenie, PMID:25066056]"}
{"concept_id": "C4235124", "aliases": ["carbon phosphorus lyase complex location"], "types": ["T026"], "canonical_name": "carbon phosphorus lyase complex", "definition": "A protein complex which is capable of carbon phosphorus lyase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17993513, PMID:21705661, PMID:22089136, PMID:23830682]"}
{"concept_id": "C4235125", "aliases": ["phosphatidylinositol phosphate phosphatase complex location"], "types": ["T026"], "canonical_name": "phosphatidylinositol phosphate phosphatase complex", "definition": "A protein complex which is capable of phosphatidylinositol phosphate phosphatase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12525165]"}
{"concept_id": "C4235126", "aliases": ["K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex location", "HCN channel complex location", "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex location", "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex", "K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex"], "types": ["T026"], "canonical_name": "HCN channel complex", "definition": "A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart. [PMID:20829353]"}
{"concept_id": "C4235127", "aliases": ["trans-synaptic protein complex location"], "types": ["T026"], "canonical_name": "trans-synaptic protein complex", "definition": "A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes. [PMID:20200227]"}
{"concept_id": "C4235128", "aliases": ["chloroplast thylakoid membrane protein complex location"], "types": ["T026"], "canonical_name": "chloroplast thylakoid membrane protein complex", "definition": "A protein complex that is part of a chloroplast thylakoid membrane. [GOC:dos]"}
{"concept_id": "C4235129", "aliases": ["respiratory chain complex location"], "types": ["T026"], "canonical_name": "respiratory chain complex", "definition": "Any protein complex that is part of a respiratory chain. [GOC:dos]"}
{"concept_id": "C4235130", "aliases": ["plasma membrane signaling receptor complex location"], "types": ["T026"], "canonical_name": "plasma membrane signaling receptor complex", "definition": "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor. [GOC:dos]"}
{"concept_id": "C4235131", "aliases": ["inner mitochondrial membrane protein complex location"], "types": ["T026"], "canonical_name": "inner mitochondrial membrane protein complex", "definition": "Any protein complex that is part of the inner mitochondrial membrane. [GOC:dos]"}
{"concept_id": "C4235132", "aliases": ["outer mitochondrial membrane protein complex location"], "types": ["T026"], "canonical_name": "outer mitochondrial membrane protein complex", "definition": "Any protein complex that is part of the outer mitochondrial membrane. [GOC:dos]"}
{"concept_id": "C4235133", "aliases": ["plasma membrane protein complex location"], "types": ["T026"], "canonical_name": "plasma membrane protein complex", "definition": "Any protein complex that is part of the plasma membrane. [GOC:dos]"}
{"concept_id": "C4235134", "aliases": ["membrane protein complex location"], "types": ["T026"], "canonical_name": "membrane protein complex", "definition": "Any protein complex that is part of a membrane. [GOC:dos]"}
{"concept_id": "C4235135", "aliases": ["glycoprotein complex location"], "types": ["T026"], "canonical_name": "glycoprotein complex", "definition": "A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. [GOC:pf, PMID:7693675, PMID:8662961]"}
{"concept_id": "C4235136", "aliases": ["box H/ACA telomerase RNP complex location"], "types": ["T026"], "canonical_name": "box H/ACA telomerase RNP complex", "definition": "A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell. [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:22527283]"}
{"concept_id": "C4235137", "aliases": ["P-TEFb complex location"], "types": ["T026"], "canonical_name": "P-TEFb complex", "definition": "A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T. [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067, Wikipedia:P-TEFb]"}
{"concept_id": "C4235138", "aliases": ["chaperone-mediated autophagy translocation complex location", "CMA translocation complex location", "CMA translocation complex"], "types": ["T026"], "canonical_name": "chaperone-mediated autophagy translocation complex", "definition": "A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy. [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626]"}
{"concept_id": "C4235139", "aliases": ["pyroptosome complex location", "ASC pyroptosome"], "types": ["T026"], "canonical_name": "pyroptosome complex", "definition": "A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis. [GOC:dph, PMID:17599095]"}
{"concept_id": "C4235140", "aliases": ["inflammasome complex location"], "types": ["T026"], "canonical_name": "inflammasome complex", "definition": "A cytosolic protein complex that is capable of activating caspase-1. [GOC:dph, PMID:17599095]"}
{"concept_id": "C4235141", "aliases": ["SEACAT complex location", "GATOR2 complex location", "SEACAT complex"], "types": ["T026"], "canonical_name": "GATOR2 complex", "definition": "A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins. [GOC:krc, GOC:rb, PMID:23723238, PMID:25934700]"}
{"concept_id": "C4235142", "aliases": ["pituitary gonadotropin complex location"], "types": ["T026"], "canonical_name": "pituitary gonadotropin complex", "definition": "A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function. [GOC:dph, PMID:11420129]"}
{"concept_id": "C4235143", "aliases": ["transferase complex location, transferring phosphorus-containing groups"], "types": ["T026"], "canonical_name": "transferase complex, transferring phosphorus-containing groups", "definition": "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). [GOC:bhm, GOC:dph]"}
{"concept_id": "C4235144", "aliases": ["alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex location"], "types": ["T026"], "canonical_name": "alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex", "definition": "A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity. [GOC:dph, PMID:22089136]"}
{"concept_id": "C4235145", "aliases": ["Derlin-1 retro-translocation complex location", "Derlin-1 retro-translocation complex", "Derlin-1 complex location", "ERAD protein dislocation complex location", "ERAD protein dislocation complex", "Derlin-1 protein dislocation complex", "Derlin-1 retrotranslocation complex location", "Derlin-1 protein dislocation complex location", "Derlin-1 retrotranslocon", "Derlin-1 complex"], "types": ["T026"], "canonical_name": "Derlin-1 retrotranslocation complex", "definition": "A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]"}
{"concept_id": "C4235146", "aliases": ["Derlin-1/VIMP complex", "Derlin-1-VIMP complex location", "Derlin-1/VIMP complex location"], "types": ["T026"], "canonical_name": "Derlin-1-VIMP complex", "definition": "A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome. [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]"}
{"concept_id": "C4235147", "aliases": ["UFD1L-NPLOC4 complex", "Ufd1-Npl4 binary complex", "Ufd1-Npl4 binary complex location", "Ufd1-Npl4 cofactor complex", "Ufd1/Npl4 complex", "Ufd1-Npl4 cofactor complex location", "Npl4p-Ufd1p complex location", "UFD1-NPL4 complex location", "Npl4p-Ufd1p complex", "Ufd1/Npl4 complex location", "UFD1L-NPLOC4 complex location"], "types": ["T026"], "canonical_name": "UFD1-NPL4 complex", "definition": "A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p. [GOC:bf, GOC:PARL, PMID:10811609, PMID:17289586]"}
{"concept_id": "C4235148", "aliases": ["p97-Ufd1-Npl4 complex location", "p97-Ufd1-Npl4 complex", "VCP-NPL4-UFD1 AAA ATPase complex location"], "types": ["T026"], "canonical_name": "VCP-NPL4-UFD1 AAA ATPase complex", "definition": "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). [PMID:11813000, PMID:16179952]"}
{"concept_id": "C4235149", "aliases": ["nucleotide-activated protein kinase complex location"], "types": ["T026"], "canonical_name": "nucleotide-activated protein kinase complex", "definition": "A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae). [GOC:bhm, GOC:mah, GOC:vw]"}
{"concept_id": "C4235150", "aliases": ["cyclin/CDK positive transcription elongation factor complex location"], "types": ["T026"], "canonical_name": "cyclin/CDK positive transcription elongation factor complex", "definition": "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473]"}
{"concept_id": "C4235151", "aliases": ["Wnt signalosome complex location", "LRP5/6 signalosome", "Wnt-LRP5/6 signalosome", "Wnt signalosome complex"], "types": ["T026"], "canonical_name": "Wnt signalosome", "definition": "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]"}
{"concept_id": "C4235152", "aliases": ["cytoplasmic side of nucleopore", "cytoplasmic side of nuclear pore complex location", "cytoplasmic side of NPC", "cytoplasmic side of nuclear pore complex"], "types": ["T026"], "canonical_name": "cytoplasmic side of nuclear pore", "definition": "The side of the nuclear pore complex (NPC) that faces the cytoplasm. [PMID:8422679]"}
{"concept_id": "C4235153", "aliases": ["nucleoplasmic side of nuclear pore complex", "nucleoplasmic side of nuclear pore complex location", "nucleoplasmic side of NPC", "nucleoplasmic side of nucleopore"], "types": ["T026"], "canonical_name": "nucleoplasmic side of nuclear pore", "definition": "The side of the nuclear pore complex (NPC) that faces the nucleoplasm. [PMID:8422679]"}
{"concept_id": "C4235215", "aliases": ["myo-inositol import into cell"], "types": ["T043"], "canonical_name": "myo-inositol import across plasma membrane", "definition": "The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:9560432]"}
{"concept_id": "C4235228", "aliases": [], "types": ["T044"], "canonical_name": "RNA N6-methyladenosine dioxygenase activity"}
{"concept_id": "C4235229", "aliases": ["protein localisation to microtubule plus-end"], "types": ["T043"], "canonical_name": "protein localization to microtubule plus-end", "definition": "A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end. [GO_REF:0000087, GOC:TermGenie, PMID:24039245]"}
{"concept_id": "C4235230", "aliases": [], "types": ["T026"], "canonical_name": "growth cone lamellipodium", "definition": "A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments. [GOC:dos, PMID:25598228]"}
{"concept_id": "C4235231", "aliases": [], "types": ["T043"], "canonical_name": "endothelial cell chemotaxis to vascular endothelial growth factor", "definition": "The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF). [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851]"}
{"concept_id": "C4235232", "aliases": ["up-regulation of membrane depolarization", "up regulation of membrane depolarization", "upregulation of membrane depolarization"], "types": ["T043"], "canonical_name": "positive regulation of membrane depolarization", "definition": "Any process that activates or increases the frequency, rate or extent of membrane depolarization. [GO_REF:0000058, GOC:TermGenie, PMID:20826763]"}
{"concept_id": "C4235233", "aliases": ["meiosis II metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "metaphase/anaphase transition of meiosis II", "definition": "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II. [ISBN:0815316194]"}
{"concept_id": "C4235234", "aliases": ["meiosis I metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "metaphase/anaphase transition of meiosis I", "definition": "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I. [ISBN:0815316194]"}
{"concept_id": "C4235235", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin ligase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase. [GOC:dph, GOC:vw, PMID:21389117]"}
{"concept_id": "C4235236", "aliases": ["meiotic exit"], "types": ["T043"], "canonical_name": "exit from meiosis", "definition": "Any process involved in the progression from anaphase/telophase of meiosis II to the creation of end products of meiosis, in which ploidy is reduced by half. [PMID:21389117]"}
{"concept_id": "C4235237", "aliases": [], "types": ["T043"], "canonical_name": "meiosis I/meiosis II transition", "definition": "The cell cycle process in which a cell progresses from meiosis I to meiosis II. [PMID:21389117]"}
{"concept_id": "C4235240", "aliases": ["RTS1 element binding", "RTS1 barrier binding"], "types": ["T045"], "canonical_name": "mating type region replication fork barrier binding", "definition": "Binding to the replication fork barrier found in the mating type region of fission yeast. [PMID:18723894]"}
{"concept_id": "C4235241", "aliases": ["metaphase chromosome retrieval to the spindle pole body", "microtubule sliding involved in kinetochore retrieval", "microtubule sliding involved in metaphase chromosome retrieval to the spindle pole body", "kinetochore retrieval", "sister kinetochore recapture", "microtubule sliding involved in sister kinetochore recapture"], "types": ["T043"], "canonical_name": "mitotic metaphase chromosome recapture", "definition": "A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate. [PMID:18256284]"}
{"concept_id": "C4235242", "aliases": [], "types": ["T026"], "canonical_name": "mitotic spindle kinetochore microtubule", "definition": "Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation. [PMID:18256284]"}
{"concept_id": "C4235244", "aliases": ["aspartyl autophosphorylation", "peptidyl-aspartate autophosphorylation"], "types": ["T044"], "canonical_name": "peptidyl-aspartic acid autophosphorylation", "definition": "The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein. [GOC:bf, GOC:PARL, PMID:26134396]"}
{"concept_id": "C4235245", "aliases": [], "types": ["T044"], "canonical_name": "xylan acetylation", "definition": "The addition of one or more acetyl groups to a xylan molecule. [PMID:26745802]"}
{"concept_id": "C4235246", "aliases": ["vascular smooth muscle cell dedifferentiation"], "types": ["T042"], "canonical_name": "vascular associated smooth muscle cell dedifferentiation", "definition": "The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19088079]"}
{"concept_id": "C4235247", "aliases": [], "types": ["T044"], "canonical_name": "splicing factor binding", "definition": "Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA. [PMID:11118435]"}
{"concept_id": "C4235248", "aliases": ["NLB", "compact nucleolus"], "types": ["T026"], "canonical_name": "nucleolus-like body", "definition": "A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles. [PMID:26226217, PMID:9021878]"}
{"concept_id": "C4235249", "aliases": [], "types": ["T043"], "canonical_name": "microtubule cytoskeleton attachment to nuclear envelope", "definition": "A process in which the microtubule cytoskeleton is attached to the nuclear envelope. [PMID:14655046, PMID:20507227]"}
{"concept_id": "C4235250", "aliases": [], "types": ["T045"], "canonical_name": "5.8S rRNA binding", "definition": "Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA. [PMID:11716358, PMID:15527424]"}
{"concept_id": "C4235251", "aliases": [], "types": ["T044"], "canonical_name": "RNA N1-methyladenosine dioxygenase activity"}
{"concept_id": "C4235252", "aliases": [], "types": ["T044"], "canonical_name": "sulfoquinovosidase activity", "definition": "Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose. [GOC:imk, PMID:26878550]"}
{"concept_id": "C4235253", "aliases": [], "types": ["T040"], "canonical_name": "response to amino acid starvation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. [PMID:7765311]"}
{"concept_id": "C4235254", "aliases": [], "types": ["T043"], "canonical_name": "calcium ion regulated lysosome exocytosis", "definition": "The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. [PMID:10725327, PMID:11511344]"}
{"concept_id": "C4235256", "aliases": ["hepatic perisinusoidal cell proliferation", "Ito cell proliferation", "perisinusoidal cell proliferation"], "types": ["T043"], "canonical_name": "hepatic stellate cell proliferation", "definition": "The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver. [GOC:sl, PMID:15358192, PMID:18466260]"}
{"concept_id": "C4235257", "aliases": ["nuclear membrane proteasome tether", "nuclear membrane proteasome tether activity", "nuclear membrane-proteasome tether activity", "nuclear membrane proteasome anchor", "nuclear membrane-proteasome anchor activity"], "types": ["T044"], "canonical_name": "proteasome-nuclear membrane anchor activity", "definition": "The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome. [PMID:16096059]"}
{"concept_id": "C4235258", "aliases": [], "types": ["T045"], "canonical_name": "double-strand break repair involved in meiotic recombination", "definition": "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination. [GOC:mah, PMID:15238514]"}
{"concept_id": "C4235259", "aliases": [], "types": ["T026"], "canonical_name": "Isp3 layer of spore wall", "definition": "The outermost layers of the spore wall, as described in Schizosaccharomyces pombe. [PMID:24623719]"}
{"concept_id": "C4235260", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of ascospore wall", "definition": "The action of a molecule that contributes to the structural integrity of an ascospore wall. [PMID:24623719]"}
{"concept_id": "C4235261", "aliases": [], "types": ["T026"], "canonical_name": "integral component of periplasmic side of plasma membrane", "definition": "The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane. [GOC:bhm, PMID:15919996]"}
{"concept_id": "C4235262", "aliases": [], "types": ["T026"], "canonical_name": "sperm head plasma membrane", "definition": "The plasma membrane that is part of the head section of a sperm cell. [PMID:24478030]"}
{"concept_id": "C4235263", "aliases": [], "types": ["T039"], "canonical_name": "response to psychosocial stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism. [PMID:22922217, PMID:26458179]"}
{"concept_id": "C4235264", "aliases": [], "types": ["T043"], "canonical_name": "response to hypobaric hypoxia", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level). [PMID:24590457]"}
{"concept_id": "C4235265", "aliases": [], "types": ["T026"], "canonical_name": "accessory outer segment", "definition": "A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors. [GOC:dph, PMID:25125189]"}
{"concept_id": "C4235266", "aliases": [], "types": ["T026"], "canonical_name": "dinoflagellate peduncle", "definition": "A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy). [GOC:at, PMID:1480107, Wikipedia:Dinoflagellate]"}
{"concept_id": "C4235267", "aliases": [], "types": ["T026"], "canonical_name": "new cell pole", "definition": "The cell pole proximal to the most recent cell division. [GOC:jh2, PMID:10231492, PMID:8226658]"}
{"concept_id": "C4235268", "aliases": [], "types": ["T026"], "canonical_name": "old cell pole", "definition": "The cell pole distal from the most recent cell division. [GOC:jh2, PMID:10231492, PMID:8226658]"}
{"concept_id": "C4235269", "aliases": ["cilium pocket collar"], "types": ["T026"], "canonical_name": "ciliary pocket collar", "definition": "A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma. [GOC:giardia, PMID:18462016, PMID:19806154]"}
{"concept_id": "C4235270", "aliases": [], "types": ["T043"], "canonical_name": "meiotic DNA double-strand break resectioning", "definition": "The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends. [PMID:26130711]"}
{"concept_id": "C4235271", "aliases": [], "types": ["T043"], "canonical_name": "meiotic DNA double-strand break clipping", "definition": "The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP). [PMID:26130711]"}
{"concept_id": "C4235272", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to cell cortex of cell tip", "definition": "A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip. [PMID:26150232]"}
{"concept_id": "C4235273", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein localization to cell cortex of cell tip", "definition": "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip. [GOC:vw, PMID:26150232]"}
{"concept_id": "C4235274", "aliases": ["mitotic chromosome condensation at kinetochore"], "types": ["T043"], "canonical_name": "mitotic chromosome centromere condensation", "definition": "The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis. [PMID:21633354]"}
{"concept_id": "C4235275", "aliases": [], "types": ["T043"], "canonical_name": "mitotic chromosome arm condensation", "definition": "The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells. [PMID:21633354]"}
{"concept_id": "C4235276", "aliases": [], "types": ["T043"], "canonical_name": "mitotic sister chromatid arm separation", "definition": "The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis. [PMID:21633354]"}
{"concept_id": "C4235277", "aliases": [], "types": ["T044"], "canonical_name": "netrin receptor binding", "definition": "Binding to a netrin receptor. [GOC:kmv, PMID:8861902, PMID:9126742]"}
{"concept_id": "C4235278", "aliases": [], "types": ["T044"], "canonical_name": "H4K20me3 modified histone binding", "definition": "Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation. [PMID:22150589]"}
{"concept_id": "C4235279", "aliases": [], "types": ["T044"], "canonical_name": "2-polyprenyl-6-hydroxyphenol O-methyltransferase activity", "definition": "Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+. [PMID:10419476]"}
{"concept_id": "C4235280", "aliases": [], "types": ["T044"], "canonical_name": "2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity", "definition": "Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+. [PMID:10419476]"}
{"concept_id": "C4235281", "aliases": [], "types": ["T044"], "canonical_name": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+. [PMID:10419476, PMID:9628017, RHEA:44452]"}
{"concept_id": "C4235282", "aliases": [], "types": ["T045"], "canonical_name": "RNA acetylation", "definition": "The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule. [PMID:25402480]"}
{"concept_id": "C4235283", "aliases": [], "types": ["T044"], "canonical_name": "rRNA cytidine N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA. [PMID:25402480]"}
{"concept_id": "C4235284", "aliases": [], "types": ["T045"], "canonical_name": "rRNA acetylation", "definition": "The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [PMID:25402480]"}
{"concept_id": "C4235285", "aliases": [], "types": ["T043"], "canonical_name": "cellular detoxification of copper ion", "definition": "Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration. [PMID:10369673]"}
{"concept_id": "C4235286", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to gastrin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus. [PMID:10348814]"}
{"concept_id": "C4235287", "aliases": ["vascular smooth muscle cell proliferation", "VSMC proliferation"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell proliferation", "definition": "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. [PMID:23246467]"}
{"concept_id": "C4235288", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of plasma membrane of cell tip", "definition": "The component of the plasma membrane surrounding the cell tip consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the plasma membrane surrounding the cell tip or some other covalently attached group such as a GPI anchor that is similarly embedded in the plasma membrane surrounding the cell tip. [PMID:20624220]"}
{"concept_id": "C4235290", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chemokine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. [PMID:11113082]"}
{"concept_id": "C4235291", "aliases": [], "types": ["T043"], "canonical_name": "response to chemokine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. [PMID:11113082]"}
{"concept_id": "C4235292", "aliases": [], "types": ["T043"], "canonical_name": "response to gastrin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus. [PMID:10348814]"}
{"concept_id": "C4235293", "aliases": ["response to somatoliberin", "response to somatocrinin", "response to GHRF", "response to somatorelin", "response to GRF", "response to growth hormone-releasing factor"], "types": ["T043"], "canonical_name": "response to growth hormone-releasing hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins. [PMID:7720628]"}
{"concept_id": "C4235294", "aliases": ["acinous cell proliferation", "acinic cell proliferation"], "types": ["T043"], "canonical_name": "acinar cell proliferation", "definition": "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). [PMID:9788538]"}
{"concept_id": "C4235295", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to endothelin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3). [PMID:16365184]"}
{"concept_id": "C4235296", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to lectin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. [PMID:25996210, PMID:26306444]"}
{"concept_id": "C4235297", "aliases": [], "types": ["T045"], "canonical_name": "methionyl-initiator methionine tRNA binding", "definition": "Binding to methionine-initator methionine tRNA. [GOC:hjd, ISBN:9781555810733]"}
{"concept_id": "C4235298", "aliases": ["vacuole-endoplasmic reticulum attachment", "vacuole-endoplasmic reticulum tethering", "vacuole-ER attachment"], "types": ["T043"], "canonical_name": "vacuole-ER tethering", "definition": "The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles. [PMID:26283797]"}
{"concept_id": "C4235299", "aliases": [], "types": ["T044"], "canonical_name": "histone H2A SQE motif phosphorylation", "definition": "The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone. [DOI:10.1038/35052000, PMID:15226425]"}
{"concept_id": "C4235300", "aliases": [], "types": ["T043"], "canonical_name": "protein transport along microtubule to spindle pole body", "definition": "The directed movement of a protein along a microtubule to the spindle pole body, mediated by motor proteins. [PMID:25987607]"}
{"concept_id": "C4235301", "aliases": ["maintenance of vacuole localization", "maintenance of vacuolar location", "maintenance of vacuolar localization", "maintenance of vacuole location"], "types": ["T043"], "canonical_name": "vacuolar localization", "definition": "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. [PMID:26283797]"}
{"concept_id": "C4235303", "aliases": [], "types": ["T044"], "canonical_name": "ribonucleoside-diphosphate reductase inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase. [PMID:16317005]"}
{"concept_id": "C4235304", "aliases": [], "types": ["T040"], "definition": "The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature. [PMID:17260010, PMID:20363363]", "canonical_name": "adaptive thermogenesis"}
{"concept_id": "C4235306", "aliases": [], "types": ["T045"], "canonical_name": "promoter-specific chromatin binding", "definition": "Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]"}
{"concept_id": "C4235307", "aliases": [], "types": ["T040"], "canonical_name": "response to lectin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. [PMID:25996210, PMID:26306444]"}
{"concept_id": "C4235308", "aliases": [], "types": ["T043"], "canonical_name": "response to endothelin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3). [PMID:16365184]"}
{"concept_id": "C4235309", "aliases": [], "types": ["T044"], "canonical_name": "poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends", "definition": "Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P). [PMID:23022480]"}
{"concept_id": "C4235310", "aliases": ["sequence-specific dsDNA binding"], "types": ["T045"], "canonical_name": "sequence-specific double-stranded DNA binding", "definition": "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]"}
{"concept_id": "C4235311", "aliases": [], "types": ["T026"], "canonical_name": "lysosomal matrix", "definition": "A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome. [PMID:9395337]"}
{"concept_id": "C4235312", "aliases": [], "types": ["T043"], "canonical_name": "response to odorant", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell. [PMID:11268007]"}
{"concept_id": "C4235313", "aliases": [], "types": ["T044"], "canonical_name": "clathrin-uncoating ATPase activity", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP. [PMID:6146630, PMID:8363588]"}
{"concept_id": "C4235314", "aliases": ["cellular response to pregnancy specific glycoprotein"], "types": ["T043"], "canonical_name": "cellular response to carcinoembryonic antigen", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins. [PMID:10202129, PMID:14597422]"}
{"concept_id": "C4235315", "aliases": ["cellular response to cholinergic differentiation factor", "cellular response to CDF"], "types": ["T043"], "canonical_name": "cellular response to leukemia inhibitory factor", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]"}
{"concept_id": "C4235316", "aliases": ["C-rich ssDNA binding"], "types": ["T045"], "canonical_name": "C-rich single-stranded DNA binding", "definition": "Binding to C-rich, single-stranded DNA. [PMID:8127654]"}
{"concept_id": "C4235317", "aliases": [], "types": ["T043"], "canonical_name": "hepatocyte dedifferentiation", "definition": "The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. [PMID:20102719]"}
{"concept_id": "C4235318", "aliases": [], "types": ["T044"], "canonical_name": "deaminase binding", "definition": "Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3). [PMID:9792439]"}
{"concept_id": "C4235319", "aliases": [], "types": ["T045"], "canonical_name": "sequence-specific mRNA binding", "definition": "Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif. [PMID:11886857]"}
{"concept_id": "C4235320", "aliases": ["response to cholinergic differentiation factor", "response to CDF", "response to LIF"], "types": ["T043"], "canonical_name": "response to leukemia inhibitory factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]"}
{"concept_id": "C4235321", "aliases": [], "types": ["T043"], "canonical_name": "basic amino acid transmembrane transport", "definition": "The directed movement of basic amino acids from one side of a membrane to the other. [GOC:dph, GOC:vw]"}
{"concept_id": "C4235323", "aliases": ["response to signal involved in mitotic DNA integrity checkpoint"], "types": ["T043"], "canonical_name": "response to mitotic DNA integrity checkpoint signaling", "definition": "A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling. [PMID:7548844]"}
{"concept_id": "C4235324", "aliases": [], "types": ["T026"], "canonical_name": "actin fusion focus", "definition": "A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location. [PMID:25825517]"}
{"concept_id": "C4235325", "aliases": [], "types": ["T043"], "canonical_name": "L-arginine transmembrane export from vacuole", "definition": "The directed movement of L-arginine out of the vacuole, across the vacuolar membrane. [PMID:26083598]"}
{"concept_id": "C4235326", "aliases": [], "types": ["T045"], "canonical_name": "RNA adenylyltransferase activity", "definition": "Catalysis of the template-independent extension of the 3'- end of an RNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA, or oligo(A) bearing a 3'-OH terminal group. [GOC:vw]"}
{"concept_id": "C4235327", "aliases": ["vacuole and mitochondria patch", "vCLAMP"], "types": ["T026"], "canonical_name": "vacuole-mitochondrion membrane contact site", "definition": "A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles. [PMID:25026035, PMID:25026036]"}
{"concept_id": "C4235328", "aliases": ["DNA reannealing activity"], "types": ["T045"], "canonical_name": "DNA/DNA annealing activity", "definition": "An activity that faciliates the formation of a complementary double-stranded DNA molecule. [PMID:22888405, PMID:25520186]"}
{"concept_id": "C4235329", "aliases": ["protection of centromeric cohesion during meiotic anaphase I"], "types": ["T043"], "canonical_name": "meiotic centromeric cohesion protection", "definition": "The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation after cohesin is cleaved by separase along the arm regions. [PMID:14730319, PMID:25533956]"}
{"concept_id": "C4235330", "aliases": [], "types": ["T026"], "canonical_name": "growth cone filopodium", "definition": "A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone. [PMID:25598228]"}
{"concept_id": "C4235331", "aliases": [], "types": ["T043"], "canonical_name": "microtubule anchoring at mitotic spindle pole body", "definition": "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end. [PMID:17486116]"}
{"concept_id": "C4235332", "aliases": [], "types": ["T043"], "canonical_name": "endoplasmic reticulum tubular network membrane organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane. [PMID:20434336]"}
{"concept_id": "C4235333", "aliases": [], "types": ["T044"], "canonical_name": "F-bar domain binding", "definition": "Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins. [PMID:20603077]"}
{"concept_id": "C4235334", "aliases": [], "types": ["T026"], "canonical_name": "central cylinder", "definition": "A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules. [GOC:kmv, PMID:2428682, PMID:26124290]"}
{"concept_id": "C4235339", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tRNA wobble position uridine thiolation", "definition": "The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. [PMID:15509579]"}
{"concept_id": "C4235340", "aliases": [], "types": ["T040"], "canonical_name": "pancreas regeneration", "definition": "The regrowth of a destroyed pancreas. [PMID:1985964]"}
{"concept_id": "C4235341", "aliases": [], "types": ["T026"], "canonical_name": "photoreceptor cell terminal bouton", "definition": "A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light. [PMID:19883736]"}
{"concept_id": "C4235342", "aliases": [], "types": ["T026"], "canonical_name": "rod bipolar cell terminal bouton", "definition": "A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer. [PMID:19883736]"}
{"concept_id": "C4235343", "aliases": [], "types": ["T026"], "canonical_name": "basolateral part of cell", "definition": "The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells. [PMID:18495799]"}
{"concept_id": "C4235344", "aliases": [], "types": ["T043"], "canonical_name": "substance P secretion, neurotransmission", "definition": "The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter. [PMID:15292051]"}
{"concept_id": "C4235345", "aliases": ["cellular response to GDNF", "cellular response to ATF", "cellular response to astrocyte-derived trophic factor"], "types": ["T043"], "canonical_name": "cellular response to glial cell derived neurotrophic factor", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus. [PMID:20877310]"}
{"concept_id": "C4235346", "aliases": ["DRG development"], "types": ["T042"], "canonical_name": "dorsal root ganglion development", "definition": "The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure. [PMID:18583150]"}
{"concept_id": "C4235347", "aliases": ["response to ATF", "response to GDNF", "response to astrocyte-derived trophic factor"], "types": ["T043"], "canonical_name": "response to glial cell derived neurotrophic factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus. [PMID:20877310]"}
{"concept_id": "C4235348", "aliases": [], "types": ["T043"], "canonical_name": "thyroid gland epithelial cell proliferation", "definition": "The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population. [PMID:17646383]"}
{"concept_id": "C4235349", "aliases": ["negative regulation of hedgehog target transcription factor"], "types": ["T044"], "canonical_name": "negative regulation of hh target transcription factor activity", "definition": "Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling. [GOC:bhm, PMID:24311597]"}
{"concept_id": "C4235350", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to dsDNA", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus. [PMID:10051633]"}
{"concept_id": "C4235351", "aliases": ["response to immobilization stress combined with water immersion"], "types": ["T039"], "canonical_name": "response to water-immersion restraint stress", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile. [PMID:10882227]"}
{"concept_id": "C4235352", "aliases": ["response to double-stranded DNA"], "types": ["T043"], "canonical_name": "response to dsDNA", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus. [PMID:10051633]"}
{"concept_id": "C4235353", "aliases": [], "types": ["T026"], "canonical_name": "periphagosomal region of cytoplasm", "definition": "Cytoplasm situated near, or occurring around, a phagosome. [PMID:18250451]"}
{"concept_id": "C4235354", "aliases": ["tyrosine kinase binding"], "types": ["T044"], "canonical_name": "protein tyrosine kinase binding", "definition": "Binding to protein tyrosine kinase. [PMID:25499537]"}
{"concept_id": "C4235355", "aliases": [], "types": ["T039"], "canonical_name": "response to immobilization stress combined with electrical stimulus", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile. [PMID:17008368]"}
{"concept_id": "C4235356", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic side of dendritic spine plasma membrane", "definition": "The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine. [PMID:9275233]"}
{"concept_id": "C4235357", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to cell periphery", "definition": "A process in which a protein is transported to, or maintained in, the cell periphery. [PMID:18216290]"}
{"concept_id": "C4235358", "aliases": [], "types": ["T026"], "canonical_name": "lipoprotein particle", "definition": "A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph. [GOC:vesicles]"}
{"concept_id": "C4235359", "aliases": [], "types": ["T043"], "canonical_name": "response to angiotensin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. [PMID:22982863]"}
{"concept_id": "C4235360", "aliases": [], "types": ["T043"], "canonical_name": "endothelin secretion"}
{"concept_id": "C4235362", "aliases": ["MMP secretion"], "types": ["T043"], "canonical_name": "matrix metallopeptidase secretion", "definition": "The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins. [PMID:8679543]"}
{"concept_id": "C4235363", "aliases": [], "types": ["T043"], "canonical_name": "substance P secretion", "definition": "The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity. [PMID:11278900]"}
{"concept_id": "C4235364", "aliases": ["clathrin-mediated extracellular exosome endocytosis", "exosome related"], "types": ["T043"], "canonical_name": "clathrin-dependent extracellular exosome endocytosis", "definition": "The clathrin-mediated endocytosis of an extracellular exosome. [PMID:24951588]"}
{"concept_id": "C4235365", "aliases": [], "types": ["T042"], "canonical_name": "small intestine smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. [PMID:11991626]"}
{"concept_id": "C4235366", "aliases": [], "types": ["T026"], "canonical_name": "proximal neuron projection", "definition": "The portion of an axon or dendrite that is close to the neuronal cell body. [PMID:21104189]"}
{"concept_id": "C4235367", "aliases": ["stomach mucosal blood circulation"], "types": ["T039"], "canonical_name": "gastric mucosal blood circulation", "definition": "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. [PMID:10807413]"}
{"concept_id": "C4235368", "aliases": [], "types": ["T043"], "canonical_name": "prostaglandin receptor internalization", "definition": "The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle. [PMID:15937517]"}
{"concept_id": "C4235369", "aliases": [], "types": ["T042"], "canonical_name": "colon smooth muscle contraction", "definition": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. [PMID:24170253]"}
{"concept_id": "C4235370", "aliases": ["MF contraction", "MFB contraction"], "types": ["T043"], "canonical_name": "myofibroblast contraction", "definition": "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast. [PMID:19239477]"}
{"concept_id": "C4235371", "aliases": [], "types": ["T044"], "canonical_name": "arrestin family protein binding", "definition": "Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors. [PMID:23911909]"}
{"concept_id": "C4235372", "aliases": [], "types": ["T045"], "canonical_name": "cytoplasmic alanyl-tRNA aminoacylation", "definition": "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation. [GOC:vw]"}
{"concept_id": "C4235373", "aliases": [], "types": ["T044"], "canonical_name": "osmolarity-sensing cation channel activity", "definition": "Enables the transmembrane transfer of a cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides. [PMID:18279313]"}
{"concept_id": "C4235374", "aliases": [], "types": ["T043"], "canonical_name": "mitotic sister chromatid biorientation", "definition": "The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression. [PMID:15309047, PMID:26258632, PMID:26705896]"}
{"concept_id": "C4235375", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin ligase activator activity", "definition": "Binds to and increases the activity of a ubiquitin ligase. [GOC:dph, PMID:25619242]"}
{"concept_id": "C4235376", "aliases": ["ubiquitin ligase substrate adaptor", "protein binding, bridging involved in substrate recognition for ubiquitination"], "types": ["T044"], "canonical_name": "ubiquitin ligase-substrate adaptor activity", "definition": "The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins. [PMID:24658274]"}
{"concept_id": "C4235377", "aliases": ["mitotic spindle microtubule depolymerisation"], "types": ["T043"], "canonical_name": "mitotic spindle microtubule depolymerization", "definition": "The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle. [PMID:25253718]"}
{"concept_id": "C4235378", "aliases": [], "types": ["T026"], "canonical_name": "equatorial cell cortex", "definition": "The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression. [GOC:kmv, PMID:16352658, PMID:22552143, PMID:23750214, PMID:25898168]"}
{"concept_id": "C4235379", "aliases": [], "types": ["T026"], "canonical_name": "microtubule end", "definition": "Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. [GOC:pr]"}
{"concept_id": "C4235380", "aliases": [], "types": ["T043"], "canonical_name": "Schwann cell chemotaxis", "definition": "The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [PMID:16203995]"}
{"concept_id": "C4235381", "aliases": [], "types": ["T044"], "canonical_name": "polynucleotide adenylyltransferase activator activity", "definition": "Increases the activity of the enzyme polynucleotide adenylyltransferase. [GOC:kmv, PMID:19460348]"}
{"concept_id": "C4235382", "aliases": [], "types": ["T043"], "canonical_name": "cellular detoxification", "definition": "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:vw]"}
{"concept_id": "C4235383", "aliases": ["pancreatic trypsinogen release"], "types": ["T043"], "canonical_name": "pancreatic trypsinogen secretion", "definition": "The regulated release of trypsinogen from the cells of the exocrine pancreas. [PMID:12771515]"}
{"concept_id": "C4235385", "aliases": [], "types": ["T043"], "canonical_name": "protein sialylation", "definition": "A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein. [PMID:21930713]"}
{"concept_id": "C4235386", "aliases": [], "types": ["T043"], "canonical_name": "granulosa cell proliferation", "definition": "The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. [PMID:22383759]"}
{"concept_id": "C4235387", "aliases": [], "types": ["T044"], "canonical_name": "pseudouridine 5'-phosphatase activity", "definition": "Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate. [EC:3.1.3.96, PMID:20722631]"}
{"concept_id": "C4235388", "aliases": ["response to manganese-induced ER stress", "response to Mn-induced ER stress", "manganese-induced ER stress response"], "types": ["T043"], "canonical_name": "response to manganese-induced endoplasmic reticulum stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus. [GOC:bf, GOC:PARL, PMID:23934647]"}
{"concept_id": "C4235389", "aliases": ["regulation of vascular smooth muscle cell membrane depolarization"], "types": ["T038"], "canonical_name": "regulation of vascular associated smooth muscle cell membrane depolarization", "definition": "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell. [PMID:20826763]"}
{"concept_id": "C4235390", "aliases": ["gamma-tubulin complex localisation to mitotic spindle pole body", "establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body", "gamma-tubulin complex localization to mitotic SPB"], "types": ["T043"], "canonical_name": "gamma-tubulin complex localization to mitotic spindle pole body", "definition": "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body. [GOC:dos, GOC:mah, PMID:11080156]"}
{"concept_id": "C4235391", "aliases": [], "types": ["T043"], "canonical_name": "astral microtubule anchoring at mitotic spindle pole body", "definition": "Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end. [PMID:15004232]"}
{"concept_id": "C4235392", "aliases": [], "types": ["T026"], "canonical_name": "pyrenoid", "definition": "A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation. [GOC:cjm, GOC:pr, PMID:23345319, Wikipedia:Pyrenoid]"}
{"concept_id": "C4235393", "aliases": ["DNA incision involved in UV-damaged DNA endonuclease-dependent excision repair", "UVDE-dependent excision repair, DNA incision", "DNA incision involved in UVER", "UV-damaged DNA endonuclease-dependent excision repair, DNA incision", "DNA incision involved in UVDE-dependent excision repair", "DNA incision involved in UV-damage excision repair", "nucleic acid cleavage involved in UV-damage excision repair"], "types": ["T045"], "canonical_name": "UV-damage excision repair, DNA incision", "definition": "A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). [PMID:10704216]"}
{"concept_id": "C4235395", "aliases": ["TMD receptor activity", "trehalose 6,6'-dimycolate receptor activity"], "types": ["T044"], "canonical_name": "cord factor receptor activity", "definition": "Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:hjd, PMID:23602766]"}
{"concept_id": "C4235396", "aliases": ["up-regulation of homologous recombinational repair", "upregulation of Rhp51-dependent recombinational repair", "upregulation of HDR", "up-regulation of HRR", "up regulation of HDR", "up regulation of homology-directed repair", "up regulation of Rad51-dependent recombinational repair", "positive regulation of HRR", "up-regulation of homology-directed repair", "up regulation of HRR", "up regulation of homologous recombinational repair", "upregulation of HRR", "upregulation of homologous recombinational repair", "up-regulation of Rad51-dependent recombinational repair", "up-regulation of Rhp51-dependent recombinational repair", "upregulation of Rad51-dependent recombinational repair", "up-regulation of HDR", "upregulation of double-strand break repair via homologous recombination", "up regulation of Rhp51-dependent recombinational repair", "up regulation of double-strand break repair via homologous recombination", "positive regulation of HDR", "upregulation of homology-directed repair", "positive regulation of homologous recombinational repair", "up-regulation of double-strand break repair via homologous recombination", "positive regulation of Rad51-dependent recombinational repair", "positive regulation of homology-directed repair", "positive regulation of Rhp51-dependent recombinational repair"], "types": ["T045"], "canonical_name": "positive regulation of double-strand break repair via homologous recombination", "definition": "Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination. [GO_REF:0000058, GOC:TermGenie, PMID:12023299]"}
{"concept_id": "C4235397", "aliases": ["up regulation of cellular protein degradation in lysosome", "up-regulation of cellular protein catabolism in lysosome", "up-regulation of cellular protein catabolic process in lysosome", "upregulation of cellular protein catabolism in lysosome", "upregulation of lysosomal protein catabolic process", "positive regulation of cellular protein catabolic process in lysosome", "up-regulation of cellular protein breakdown in lysosome", "positive regulation of lysosomal protein catabolism", "up-regulation of cellular protein degradation in lysosome", "positive regulation of cellular protein catabolism in lysosome", "up regulation of lysosomal protein catabolic process", "upregulation of lysosomal protein degradation", "up regulation of lysosomal protein catabolism", "up-regulation of lysosomal protein catabolism", "upregulation of cellular protein catabolic process in lysosome", "positive regulation of cellular protein breakdown in lysosome", "positive regulation of cellular protein degradation in lysosome", "up regulation of cellular protein catabolic process in lysosome", "up-regulation of lysosomal protein degradation", "up regulation of cellular protein breakdown in lysosome", "upregulation of lysosomal protein catabolism", "upregulation of cellular protein breakdown in lysosome", "up-regulation of lysosomal protein catabolic process", "positive regulation of lysosomal protein degradation", "up regulation of cellular protein catabolism in lysosome", "upregulation of cellular protein degradation in lysosome", "up regulation of lysosomal protein degradation"], "types": ["T044"], "canonical_name": "positive regulation of lysosomal protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235398", "aliases": ["down-regulation of lysosomal protein catabolic process", "negative regulation of cellular protein catabolism in lysosome", "down regulation of lysosomal protein catabolism", "down-regulation of cellular protein catabolic process in lysosome", "down regulation of lysosomal protein degradation", "down regulation of cellular protein degradation in lysosome", "downregulation of lysosomal protein degradation", "downregulation of cellular protein degradation in lysosome", "down regulation of cellular protein catabolism in lysosome", "downregulation of cellular protein breakdown in lysosome", "downregulation of cellular protein catabolism in lysosome", "negative regulation of cellular protein catabolic process in lysosome", "down-regulation of cellular protein breakdown in lysosome", "downregulation of cellular protein catabolic process in lysosome", "down regulation of cellular protein catabolic process in lysosome", "down-regulation of lysosomal protein degradation", "negative regulation of lysosomal protein degradation", "downregulation of lysosomal protein catabolism", "down-regulation of cellular protein degradation in lysosome", "down regulation of cellular protein breakdown in lysosome", "down regulation of lysosomal protein catabolic process", "negative regulation of cellular protein breakdown in lysosome", "negative regulation of lysosomal protein catabolism", "down-regulation of lysosomal protein catabolism", "downregulation of lysosomal protein catabolic process", "negative regulation of cellular protein degradation in lysosome", "down-regulation of cellular protein catabolism in lysosome"], "types": ["T044"], "canonical_name": "negative regulation of lysosomal protein catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235399", "aliases": ["regulation of cellular protein catabolic process in lysosome", "regulation of cellular protein catabolism in lysosome", "regulation of lysosomal protein degradation", "regulation of cellular protein degradation in lysosome", "regulation of lysosomal protein catabolism", "regulation of cellular protein breakdown in lysosome"], "types": ["T044"], "canonical_name": "regulation of lysosomal protein catabolic process", "definition": "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937]"}
{"concept_id": "C4235400", "aliases": ["up regulation of phagosome maturation", "upregulation of phagosome maturation", "up-regulation of phagosome maturation"], "types": ["T043"], "canonical_name": "positive regulation of phagosome maturation", "definition": "Any process that activates or increases the frequency, rate or extent of phagosome maturation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235401", "aliases": ["down regulation of phagosome maturation", "down-regulation of phagosome maturation", "downregulation of phagosome maturation"], "types": ["T043"], "canonical_name": "negative regulation of phagosome maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phagosome maturation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235402", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phagosome maturation", "definition": "Any process that modulates the frequency, rate or extent of phagosome maturation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16908865, PMID:23303671]"}
{"concept_id": "C4235403", "aliases": ["protein localisation to phagosome", "protein localisation in phagocytic vesicle", "protein recruitment to phagosome", "protein localisation to phagocytic vesicle", "protein localization in phagocytic vesicle"], "types": ["T043"], "canonical_name": "protein localization to phagocytic vesicle", "definition": "A process in which a protein is transported to, or maintained in, a location within a phagocytic vesicle. [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671]"}
{"concept_id": "C4235404", "aliases": ["up regulation of photosynthesis", "up-regulation of photosynthesis", "upregulation of photosynthesis"], "types": ["T039"], "canonical_name": "positive regulation of photosynthesis", "definition": "Any process that activates or increases the frequency, rate or extent of photosynthesis. [GO_REF:0000058, GOC:TermGenie, PMID:7592491]"}
{"concept_id": "C4235405", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of photosynthesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of photosynthesis. [GO_REF:0000058, GOC:TermGenie, PMID:7592491]"}
{"concept_id": "C4235406", "aliases": ["up-regulation of membrane invagination", "up regulation of membrane invagination", "upregulation of membrane invagination"], "types": ["T043"], "canonical_name": "positive regulation of membrane invagination", "definition": "Any process that activates or increases the frequency, rate or extent of membrane invagination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235407", "aliases": ["down regulation of membrane invagination", "down-regulation of membrane invagination", "downregulation of membrane invagination"], "types": ["T043"], "canonical_name": "negative regulation of membrane invagination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]"}
{"concept_id": "C4235408", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane invagination", "definition": "Any process that modulates the frequency, rate or extent of membrane invagination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]"}
{"concept_id": "C4235409", "aliases": ["positive regulation of voltage-sensitive sodium channel", "positive regulation of voltage-dependent sodium channel activity", "positive regulation of voltage gated sodium channel activity", "positive regulation of voltage-gated sodium ion channel activity"], "types": ["T044"], "canonical_name": "positive regulation of voltage-gated sodium channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:24198377]"}
{"concept_id": "C4235410", "aliases": ["negative regulation of voltage-dependent sodium channel activity", "negative regulation of voltage-gated sodium ion channel activity", "negative regulation of voltage-sensitive sodium channel", "negative regulation of voltage gated sodium channel activity"], "types": ["T044"], "canonical_name": "negative regulation of voltage-gated sodium channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated sodium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:24198377]"}
{"concept_id": "C4235411", "aliases": ["regulation of voltage-dependent sodium channel activity", "regulation of voltage gated sodium channel activity", "regulation of voltage-gated sodium ion channel activity", "regulation of voltage-sensitive sodium channel"], "types": ["T043"], "canonical_name": "regulation of voltage-gated sodium channel activity", "definition": "Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:24198377]"}
{"concept_id": "C4235412", "aliases": ["up-regulation of smooth muscle hypertrophy", "upregulation of smooth muscle hypertrophy", "up regulation of smooth muscle hypertrophy"], "types": ["T039"], "canonical_name": "positive regulation of smooth muscle hypertrophy", "definition": "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]"}
{"concept_id": "C4235413", "aliases": ["down-regulation of smooth muscle hypertrophy", "down regulation of smooth muscle hypertrophy", "downregulation of smooth muscle hypertrophy"], "types": ["T039"], "canonical_name": "negative regulation of smooth muscle hypertrophy", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]"}
{"concept_id": "C4235414", "aliases": [], "types": ["T042"], "canonical_name": "regulation of smooth muscle hypertrophy", "definition": "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]"}
{"concept_id": "C4235415", "aliases": ["cellular protein degradation in lysosome", "lysosomal protein catabolism", "cellular protein breakdown in lysosome", "lysosomal protein degradation", "cellular protein catabolism in lysosome", "cellular protein catabolic process in lysosome"], "types": ["T043"], "canonical_name": "lysosomal protein catabolic process", "definition": "Any cellular protein catabolic process that takes place in a lysosome. [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]"}
{"concept_id": "C4235416", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to acetylcholine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21238497]"}
{"concept_id": "C4235417", "aliases": [], "types": ["T043"], "canonical_name": "response to acetylcholine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21238497]"}
{"concept_id": "C4235418", "aliases": ["eukaryotic translation initiation factor 2 complex formation", "eIF-2 assembly", "eIF-2 formation", "eIF2 assembly", "eIF2 formation"], "types": ["T044"], "canonical_name": "eukaryotic translation initiation factor 2 complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex. [GO_REF:0000079, GOC:TermGenie, PMID:23775072]"}
{"concept_id": "C4235419", "aliases": ["downregulation of apical ectodermal ridge formation", "down regulation of apical ectodermal ridge formation", "downregulation of apical epidermal ridge formation", "down-regulation of apical ectodermal ridge formation", "negative regulation of apical epidermal ridge formation", "down regulation of apical epidermal ridge formation", "down-regulation of apical epidermal ridge formation"], "types": ["T042"], "canonical_name": "negative regulation of apical ectodermal ridge formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. [GO_REF:0000058, GOC:TermGenie, PMID:18359901]"}
{"concept_id": "C4235420", "aliases": ["apical epidermal ridge formation"], "types": ["T042"], "canonical_name": "apical ectodermal ridge formation", "definition": "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583]"}
{"concept_id": "C4235421", "aliases": ["upregulation of viral DNA genome packaging via site-specific sequence recognition", "up-regulation of viral DNA genome packaging via site-specific sequence recognition", "up regulation of viral DNA genome packaging via site-specific sequence recognition"], "types": ["T043"], "canonical_name": "positive regulation of viral DNA genome packaging via site-specific sequence recognition", "definition": "Any process that activates or increases the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition. [GO_REF:0000058, GOC:TermGenie, PMID:24711378]"}
{"concept_id": "C4235422", "aliases": [], "types": ["T043"], "canonical_name": "regulation of viral DNA genome packaging via site-specific sequence recognition", "definition": "Any process that modulates the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition. [GO_REF:0000058, GOC:TermGenie, PMID:24711378]"}
{"concept_id": "C4235423", "aliases": ["dethiobiotin import into cell"], "types": ["T043"], "canonical_name": "dethiobiotin import across plasma membrane", "definition": "The directed movement of dethiobiotin from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:12557275]"}
{"concept_id": "C4235424", "aliases": ["biotin import into cell"], "types": ["T043"], "canonical_name": "biotin import across plasma membrane", "definition": "The directed movement of biotin from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:12557275]"}
{"concept_id": "C4235425", "aliases": ["up regulation of meiotic chromosome resolution", "up regulation of meiotic chromosome separation", "positive regulation of chromosome separation during meiosis", "upregulation of meiotic chromosome separation", "upregulation of meiotic chromosome resolution", "up-regulation of meiotic chromosome resolution", "up regulation of chromosome separation during meiosis", "positive regulation of meiotic chromosome resolution", "upregulation of chromosome separation during meiosis", "up-regulation of chromosome separation during meiosis", "up-regulation of meiotic chromosome separation"], "types": ["T043"], "canonical_name": "positive regulation of meiotic chromosome separation", "definition": "Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]"}
{"concept_id": "C4235426", "aliases": ["downregulation of meiotic chromosome resolution", "downregulation of meiotic chromosome separation", "down-regulation of chromosome separation during meiosis", "down regulation of meiotic chromosome resolution", "downregulation of chromosome separation during meiosis", "down-regulation of meiotic chromosome resolution", "down regulation of meiotic chromosome separation", "down-regulation of meiotic chromosome separation", "down regulation of chromosome separation during meiosis", "negative regulation of meiotic chromosome resolution", "negative regulation of chromosome separation during meiosis"], "types": ["T043"], "canonical_name": "negative regulation of meiotic chromosome separation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]"}
{"concept_id": "C4235427", "aliases": ["regulation of meiotic chromosome resolution", "regulation of chromosome separation during meiosis"], "types": ["T043"], "canonical_name": "regulation of meiotic chromosome separation", "definition": "Any process that modulates the frequency, rate or extent of meiotic chromosome separation. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]"}
{"concept_id": "C4235428", "aliases": [], "types": ["T044"], "canonical_name": "carcinine transmembrane transporter activity", "definition": "Enables the transfer of carcinine from one side of a membrane to the other. [GO_REF:0000070, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872]"}
{"concept_id": "C4235429", "aliases": [], "types": ["T043"], "canonical_name": "carcinine import across plasma membrane", "definition": "The directed movement of carcinine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872]"}
{"concept_id": "C4235430", "aliases": ["endocannabinoid signalling pathway involved in trans-synaptic signaling by endocannabinoid"], "types": ["T044"], "canonical_name": "endocannabinoid signaling pathway involved in trans-synaptic signaling", "definition": "Any endocannabinoid signaling pathway that is involved in trans-synaptic signaling by endocannabinoid. [GO_REF:0000060, GOC:TermGenie, PMID:23040807]"}
{"concept_id": "C4235431", "aliases": ["upregulation of axo-dendritic protein transport", "up-regulation of axo-dendritic protein transport", "up regulation of axo-dendritic protein transport"], "types": ["T043"], "canonical_name": "positive regulation of axo-dendritic protein transport", "definition": "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:20694152]"}
{"concept_id": "C4235432", "aliases": ["down-regulation of axo-dendritic protein transport", "down regulation of axo-dendritic protein transport", "downregulation of axo-dendritic protein transport"], "types": ["T043"], "canonical_name": "negative regulation of axo-dendritic protein transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:20694152]"}
{"concept_id": "C4235433", "aliases": [], "types": ["T043"], "canonical_name": "regulation of axo-dendritic protein transport", "definition": "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:20694152]"}
{"concept_id": "C4235434", "aliases": ["positive regulation of glucosylcerebrosidase activity", "up regulation of ceramide glucosidase activity", "positive regulation of glucosylsphingosine beta-D-glucosidase activity", "upregulation of glucosylsphingosine beta-glucosidase activity", "upregulation of glucosphingosine glucosylhydrolase activity", "up-regulation of glucosphingosine glucosylhydrolase activity", "up-regulation of glucosylcerebrosidase activity", "up-regulation of beta-glucosylceramidase activity", "positive regulation of GlcCer-beta-glucosidase activity", "up regulation of glucosphingosine glucosylhydrolase activity", "positive regulation of beta-glucocerebrosidase activity", "up regulation of beta-glucosylceramidase activity", "up regulation of glucosylsphingosine beta-glucosidase activity", "up-regulation of glucosylceramidase activity", "positive regulation of ceramide glucosidase activity", "positive regulation of glucosylsphingosine beta-glucosidase activity", "up-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity", "up-regulation of glucosylsphingosine beta-glucosidase activity", "up regulation of glucosylceramidase activity", "upregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity", "upregulation of beta-glucosylceramidase activity", "upregulation of psychosine hydrolase activity", "up regulation of beta-D-glucocerebrosidase activity", "upregulation of ceramide glucosidase activity", "up regulation of glucocerebrosidase activity", "positive regulation of psychosine hydrolase activity", "up regulation of glucosylcerebrosidase activity", "positive regulation of beta-glucosylceramidase activity", "upregulation of beta-D-glucocerebrosidase activity", "positive regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity", "up-regulation of beta-glucocerebrosidase activity", "upregulation of beta-glucocerebrosidase activity", "up-regulation of beta-D-glucocerebrosidase activity", "positive regulation of GCase activity", "up regulation of beta-glucocerebrosidase activity", "upregulation of glucosylcerebrosidase activity", "positive regulation of glucosphingosine glucosylhydrolase activity", "positive regulation of acid beta-glucosidase activity", "up-regulation of glucosylsphingosine beta-D-glucosidase activity", "upregulation of acid beta-glucosidase activity", "upregulation of GlcCer-beta-glucosidase activity", "up-regulation of glucocerebrosidase activity", "upregulation of glucosylsphingosine beta-D-glucosidase activity", "up-regulation of GlcCer-beta-glucosidase activity", "up regulation of psychosine hydrolase activity", "up-regulation of acid beta-glucosidase activity", "up-regulation of psychosine hydrolase activity", "upregulation of glucocerebrosidase activity", "positive regulation of beta-D-glucocerebrosidase activity", "up regulation of glucosylsphingosine beta-D-glucosidase activity", "upregulation of glucosylceramidase activity", "positive regulation of glucocerebrosidase activity", "up regulation of GlcCer-beta-glucosidase activity", "up regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity", "up regulation of acid beta-glucosidase activity", "up-regulation of ceramide glucosidase activity"], "types": ["T044"], "canonical_name": "positive regulation of glucosylceramidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of glucosylceramidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235435", "aliases": ["down-regulation of beta-D-glucocerebrosidase activity", "downregulation of glucosylsphingosine beta-D-glucosidase activity", "downregulation of beta-glucocerebrosidase activity", "down regulation of beta-glucosylceramidase activity", "downregulation of beta-D-glucocerebrosidase activity", "negative regulation of glucosphingosine glucosylhydrolase activity", "negative regulation of beta-D-glucocerebrosidase activity", "downregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity", "negative regulation of GCase activity", "down-regulation of psychosine hydrolase activity", "downregulation of glucosylsphingosine beta-glucosidase activity", "down regulation of GlcCer-beta-glucosidase activity", "downregulation of acid beta-glucosidase activity", "negative regulation of acid beta-glucosidase activity", "negative regulation of glucosylsphingosine beta-D-glucosidase activity", "down-regulation of glucosylsphingosine beta-D-glucosidase activity", "down regulation of glucosylceramidase activity", "down regulation of glucosylsphingosine beta-D-glucosidase activity", "downregulation of beta-glucosylceramidase activity", "down regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity", "down-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity", "down-regulation of glucosylcerebrosidase activity", "downregulation of glucosphingosine glucosylhydrolase activity", "negative regulation of glucosylsphingosine beta-glucosidase activity", "down-regulation of glucosylsphingosine beta-glucosidase activity", "negative regulation of psychosine hydrolase activity", "downregulation of glucosylcerebrosidase activity", "down regulation of glucosphingosine glucosylhydrolase activity", "negative regulation of beta-glucosylceramidase activity", "down-regulation of glucosylceramidase activity", "down-regulation of GlcCer-beta-glucosidase activity", "down regulation of ceramide glucosidase activity", "negative regulation of glucosylcerebrosidase activity", "down regulation of beta-D-glucocerebrosidase activity", "down regulation of glucosylsphingosine beta-glucosidase activity", "downregulation of glucosylceramidase activity", "down-regulation of ceramide glucosidase activity", "downregulation of GlcCer-beta-glucosidase activity", "negative regulation of GlcCer-beta-glucosidase activity", "negative regulation of beta-glucocerebrosidase activity", "down regulation of glucocerebrosidase activity", "down-regulation of glucosphingosine glucosylhydrolase activity", "downregulation of glucocerebrosidase activity", "down regulation of psychosine hydrolase activity", "downregulation of ceramide glucosidase activity", "down regulation of glucosylcerebrosidase activity", "negative regulation of ceramide glucosidase activity", "negative regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity", "down regulation of beta-glucocerebrosidase activity", "down regulation of acid beta-glucosidase activity", "down-regulation of glucocerebrosidase activity", "downregulation of psychosine hydrolase activity", "down-regulation of acid beta-glucosidase activity", "down-regulation of beta-glucosylceramidase activity", "negative regulation of glucocerebrosidase activity", "down-regulation of beta-glucocerebrosidase activity"], "types": ["T044"], "canonical_name": "negative regulation of glucosylceramidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucosylceramidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235436", "aliases": ["regulation of acid beta-glucosidase activity", "regulation of glucocerebrosidase activity", "regulation of glucosylsphingosine beta-glucosidase activity", "regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity", "regulation of psychosine hydrolase activity", "regulation of GlcCer-beta-glucosidase activity", "regulation of GCase activity", "regulation of glucosylsphingosine beta-D-glucosidase activity", "regulation of ceramide glucosidase activity", "regulation of glucosylcerebrosidase activity", "regulation of beta-glucocerebrosidase activity", "regulation of beta-glucosylceramidase activity", "regulation of beta-D-glucocerebrosidase activity", "regulation of glucosphingosine glucosylhydrolase activity"], "types": ["T044"], "canonical_name": "regulation of glucosylceramidase activity", "definition": "Any process that modulates the frequency, rate or extent of glucosylceramidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]"}
{"concept_id": "C4235438", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to haloperidol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus. [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]"}
{"concept_id": "C4235439", "aliases": [], "types": ["T043"], "canonical_name": "response to haloperidol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus. [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]"}
{"concept_id": "C4235440", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ribonucleoside-diphosphate reductase activity", "definition": "Any process that activates or increases the frequency, rate or extent of ribonucleoside-diphosphate reductase activity. [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891]"}
{"concept_id": "C4235441", "aliases": ["regulation of ribonucleotide diphosphate reductase activity"], "types": ["T044"], "canonical_name": "regulation of ribonucleoside-diphosphate reductase activity", "definition": "Any process that modulates the frequency, rate or extent of ribonucleoside-diphosphate reductase activity. [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891]"}
{"concept_id": "C4235442", "aliases": ["upregulation of lateral attachment of mitotic spindle microtubules to kinetochore", "up-regulation of lateral attachment of mitotic spindle microtubules to kinetochore", "up regulation of lateral attachment of mitotic spindle microtubules to kinetochore"], "types": ["T043"], "canonical_name": "positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore", "definition": "Any process that activates or increases the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore. [GO_REF:0000058, GOC:TermGenie, PMID:22375062]"}
{"concept_id": "C4235443", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lateral attachment of mitotic spindle microtubules to kinetochore", "definition": "Any process that modulates the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore. [GO_REF:0000058, GOC:TermGenie, PMID:22375062]"}
{"concept_id": "C4235444", "aliases": ["cell surface receptor signaling pathway involved in cell-cell signalling", "cell surface receptor linked signaling pathway involved in cell-cell signaling", "cell surface receptor linked signalling pathway involved in cell-cell signaling", "cell surface receptor linked signaling pathway involved in cell-cell signalling", "cell surface receptor linked signal transduction involved in cell-cell signalling", "cell surface receptor linked signal transduction involved in cell-cell signaling", "cell surface receptor linked signalling pathway involved in cell-cell signalling"], "types": ["T043"], "canonical_name": "cell surface receptor signaling pathway involved in cell-cell signaling", "definition": "Any cell surface receptor signaling pathway that is involved in cell-cell signaling. [GO_REF:0000060, GOC:TermGenie, ISBN:0-7167-3051-0]"}
{"concept_id": "C4235447", "aliases": ["up regulation of pulmonary blood vessel remodeling", "up-regulation of pulmonary blood vessel remodeling", "upregulation of pulmonary blood vessel remodeling"], "types": ["T039"], "canonical_name": "positive regulation of pulmonary blood vessel remodeling", "definition": "Any process that activates or increases the frequency, rate or extent of pulmonary blood vessel remodeling. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]"}
{"concept_id": "C4235448", "aliases": ["down regulation of pulmonary blood vessel remodeling", "downregulation of pulmonary blood vessel remodeling", "down-regulation of pulmonary blood vessel remodeling"], "types": ["T042"], "canonical_name": "negative regulation of pulmonary blood vessel remodeling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pulmonary blood vessel remodeling. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]"}
{"concept_id": "C4235449", "aliases": [], "types": ["T042"], "canonical_name": "regulation of pulmonary blood vessel remodeling", "definition": "Any process that modulates the frequency, rate or extent of pulmonary blood vessel remodeling. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]"}
{"concept_id": "C4235450", "aliases": [], "types": ["T045"], "canonical_name": "guanosine binding", "definition": "Binding to guanosine. [GO_REF:0000067, GOC:TermGenie, PMID:26007660]"}
{"concept_id": "C4235451", "aliases": ["integral component of lysosome membrane"], "types": ["T026"], "canonical_name": "integral component of lysosomal membrane", "definition": "The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GO_REF:0000064, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26134396]"}
{"concept_id": "C4235452", "aliases": ["up-regulation of apoptosome formation", "up-regulation of apoptosome assembly", "upregulation of apoptosome formation", "positive regulation of apoptosome formation", "up regulation of apoptosome assembly", "up regulation of apoptosome formation", "upregulation of apoptosome assembly"], "types": ["T043"], "canonical_name": "positive regulation of apoptosome assembly", "definition": "Any process that activates or increases the frequency, rate or extent of apoptosome assembly. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]"}
{"concept_id": "C4235453", "aliases": ["downregulation of apoptosome formation", "down regulation of apoptosome assembly", "downregulation of apoptosome assembly", "down-regulation of apoptosome formation", "negative regulation of apoptosome formation", "down regulation of apoptosome formation", "down-regulation of apoptosome assembly"], "types": ["T043"], "canonical_name": "negative regulation of apoptosome assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptosome assembly. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]"}
{"concept_id": "C4235454", "aliases": ["regulation of apoptosome formation"], "types": ["T044"], "canonical_name": "regulation of apoptosome assembly", "definition": "Any process that modulates the frequency, rate or extent of apoptosome assembly. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]"}
{"concept_id": "C4235455", "aliases": ["positive regulation of guanyl-nucleotide releasing factor", "up-regulation of guanyl-nucleotide releasing factor", "positive regulation of GDS", "up regulation of guanyl-nucleotide releasing factor", "upregulation of guanyl-nucleotide releasing factor", "upregulation of GEF", "positive regulation of GEF", "up-regulation of GEF", "up regulation of GDS", "up-regulation of guanyl-nucleotide exchange factor activity", "positive regulation of guanyl-nucleotide release factor activity", "up regulation of guanyl-nucleotide exchange factor activity", "upregulation of GDS", "up regulation of GDP-dissociation stimulator activity", "positive regulation of GDP-dissociation stimulator activity", "up-regulation of guanyl-nucleotide release factor activity", "up-regulation of GDS", "up regulation of GEF", "upregulation of guanyl-nucleotide exchange factor activity", "upregulation of GDP-dissociation stimulator activity", "upregulation of guanyl-nucleotide release factor activity", "up regulation of guanyl-nucleotide release factor activity", "up-regulation of GDP-dissociation stimulator activity"], "types": ["T044"], "canonical_name": "positive regulation of guanyl-nucleotide exchange factor activity", "definition": "Any process that activates or increases the frequency, rate or extent of guanyl-nucleotide exchange factor activity. [GO_REF:0000059, GOC:TermGenie, PMID:20484009]"}
{"concept_id": "C4235456", "aliases": ["down regulation of GDP-dissociation stimulator activity", "down regulation of GEF", "negative regulation of GDS", "negative regulation of GDP-dissociation stimulator activity", "down regulation of guanyl-nucleotide exchange factor activity", "down-regulation of GEF", "negative regulation of GEF", "down-regulation of GDS", "negative regulation of guanyl-nucleotide releasing factor", "down-regulation of guanyl-nucleotide release factor activity", "down regulation of guanyl-nucleotide releasing factor", "downregulation of guanyl-nucleotide release factor activity", "negative regulation of guanyl-nucleotide release factor activity", "down-regulation of GDP-dissociation stimulator activity", "down-regulation of guanyl-nucleotide exchange factor activity", "downregulation of guanyl-nucleotide releasing factor", "downregulation of GEF", "down regulation of GDS", "downregulation of GDP-dissociation stimulator activity", "down regulation of guanyl-nucleotide release factor activity", "downregulation of GDS", "downregulation of guanyl-nucleotide exchange factor activity", "down-regulation of guanyl-nucleotide releasing factor"], "types": ["T044"], "canonical_name": "negative regulation of guanyl-nucleotide exchange factor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity. [GO_REF:0000059, GOC:TermGenie, PMID:20484009]"}
{"concept_id": "C4235457", "aliases": ["regulation of GDP-dissociation stimulator activity", "regulation of GEF", "regulation of guanyl-nucleotide release factor activity", "regulation of guanyl-nucleotide releasing factor", "regulation of GDS"], "types": ["T044"], "canonical_name": "regulation of guanyl-nucleotide exchange factor activity", "definition": "Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity. [GO_REF:0000059, GOC:TermGenie, PMID:20484009]"}
{"concept_id": "C4235458", "aliases": ["positive regulation of apolipoprotein A-I-mediated signalling pathway", "upregulation of apolipoprotein A-I-mediated signaling pathway", "up regulation of apolipoprotein A-I-mediated signalling pathway", "upregulation of apolipoprotein A-I-mediated signalling pathway", "up-regulation of apolipoprotein A-I-mediated signalling pathway", "up-regulation of apolipoprotein A-I-mediated signaling pathway", "up regulation of apolipoprotein A-I-mediated signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of apolipoprotein A-I-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]"}
{"concept_id": "C4235459", "aliases": ["down-regulation of apolipoprotein A-I-mediated signaling pathway", "down regulation of apolipoprotein A-I-mediated signaling pathway", "down-regulation of apolipoprotein A-I-mediated signalling pathway", "downregulation of apolipoprotein A-I-mediated signalling pathway", "downregulation of apolipoprotein A-I-mediated signaling pathway", "down regulation of apolipoprotein A-I-mediated signalling pathway", "negative regulation of apolipoprotein A-I-mediated signalling pathway"], "types": ["T044"], "canonical_name": "negative regulation of apolipoprotein A-I-mediated signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]"}
{"concept_id": "C4235460", "aliases": ["regulation of apolipoprotein A-I-mediated signalling pathway"], "types": ["T043"], "canonical_name": "regulation of apolipoprotein A-I-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]"}
{"concept_id": "C4235461", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to diosgenin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus. [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]"}
{"concept_id": "C4235462", "aliases": [], "types": ["T043"], "canonical_name": "response to diosgenin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus. [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]"}
{"concept_id": "C4235463", "aliases": ["positive regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization", "up regulation of parkin-mediated mitophagy in response to mitochondrial depolarization", "upregulation of parkin-mediated mitophagy in response to mitochondrial depolarization", "positive regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization", "up-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization"], "types": ["T043"], "canonical_name": "positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization", "definition": "Any process that activates or increases the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284]"}
{"concept_id": "C4235464", "aliases": ["downregulation of parkin-mediated mitophagy in response to mitochondrial depolarization", "down regulation of parkin-mediated mitophagy in response to mitochondrial depolarization", "negative regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization", "negative regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization", "down-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization"], "types": ["T043"], "canonical_name": "negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284]"}
{"concept_id": "C4235465", "aliases": ["regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization", "regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization"], "types": ["T043"], "canonical_name": "regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization", "definition": "Any process that modulates the frequency, rate or extent of a parkin-mediated process that positively regulates mitophagy in response to mitochondrial depolarization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284]"}
{"concept_id": "C4235466", "aliases": ["upregulation of synaptonemal complex formation", "positive regulation of synaptonemal complex formation", "up regulation of synaptonemal complex assembly", "up regulation of synaptonemal complex formation", "upregulation of synaptonemal complex assembly", "up-regulation of synaptonemal complex formation", "up-regulation of synaptonemal complex assembly"], "types": ["T043"], "canonical_name": "positive regulation of synaptonemal complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of synaptonemal complex assembly. [GO_REF:0000058, GOC:TermGenie, PMID:24797370]"}
{"concept_id": "C4235467", "aliases": ["upregulation of bioluminescence", "up-regulation of bioluminescence", "up regulation of bioluminescence"], "types": ["T044"], "canonical_name": "positive regulation of bioluminescence", "definition": "Any process that activates or increases the frequency, rate or extent of bioluminescence. [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092]"}
{"concept_id": "C4235468", "aliases": ["down regulation of bioluminescence", "downregulation of bioluminescence", "down-regulation of bioluminescence"], "types": ["T044"], "canonical_name": "negative regulation of bioluminescence", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of bioluminescence. [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092]"}
{"concept_id": "C4235469", "aliases": [], "types": ["T043"], "canonical_name": "regulation of bioluminescence", "definition": "Any process that modulates the frequency, rate or extent of bioluminescence. [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092]"}
{"concept_id": "C4235470", "aliases": ["upregulation of mitochondrial translational elongation", "upregulation of mitochondrial translation elongation", "up regulation of mitochondrial translational elongation", "positive regulation of mitochondrial translation elongation", "up-regulation of mitochondrial translation elongation", "up regulation of mitochondrial translation elongation", "up-regulation of mitochondrial translational elongation"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial translational elongation", "definition": "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation. [GO_REF:0000058, GOC:TermGenie, PMID:25738458]"}
{"concept_id": "C4235471", "aliases": ["down-regulation of mitochondrial translation elongation", "downregulation of mitochondrial translational elongation", "downregulation of mitochondrial translation elongation", "down regulation of mitochondrial translation elongation", "negative regulation of mitochondrial translation elongation", "down-regulation of mitochondrial translational elongation", "down regulation of mitochondrial translational elongation"], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial translational elongation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation. [GO_REF:0000058, GOC:TermGenie, PMID:25738458]"}
{"concept_id": "C4235472", "aliases": ["regulation of mitochondrial translation elongation"], "types": ["T043"], "canonical_name": "regulation of mitochondrial translational elongation", "definition": "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation. [GO_REF:0000058, GOC:TermGenie, PMID:25738458]"}
{"concept_id": "C4235473", "aliases": ["upregulation of cerebellar neuron development", "up-regulation of cerebellar neuron development", "up regulation of cerebellar neuron development"], "types": ["T043"], "canonical_name": "positive regulation of cerebellar neuron development", "definition": "Any process that activates or increases the frequency, rate or extent of cerebellar neuron development. [GO_REF:0000058, GOC:TermGenie, PMID:26609159]"}
{"concept_id": "C4235474", "aliases": ["down-regulation of cerebellar neuron development", "downregulation of cerebellar neuron development", "down regulation of cerebellar neuron development"], "types": ["T043"], "canonical_name": "negative regulation of cerebellar neuron development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development. [GO_REF:0000058, GOC:TermGenie, PMID:26609159]"}
{"concept_id": "C4235475", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cerebellar neuron development", "definition": "Any process that modulates the frequency, rate or extent of cerebellar neuron development. [GO_REF:0000058, GOC:TermGenie, PMID:26609159]"}
{"concept_id": "C4235479", "aliases": ["up-regulation of occluding cell junction disassembly", "up regulation of occluding cell junction disassembly", "positive regulation of occluding junction disassembly", "upregulation of tight junction disassembly", "positive regulation of occluding cell junction disassembly", "upregulation of occluding cell junction disassembly", "up-regulation of tight junction disassembly", "up regulation of tight junction disassembly"], "types": ["T043"], "canonical_name": "positive regulation of tight junction disassembly", "definition": "Any process that activates or increases the frequency, rate or extent of tight junction disassembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]"}
{"concept_id": "C4235480", "aliases": ["downregulation of occluding cell junction disassembly", "negative regulation of occluding cell junction disassembly", "down regulation of occluding cell junction disassembly", "downregulation of occluding junction disassembly", "down-regulation of tight junction disassembly", "downregulation of tight junction disassembly", "down regulation of tight junction disassembly", "down-regulation of occluding cell junction disassembly"], "types": ["T043"], "canonical_name": "negative regulation of tight junction disassembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction disassembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]"}
{"concept_id": "C4235481", "aliases": ["regulation of occluding junction disassembly", "regulation of occluding cell junction disassembly"], "types": ["T043"], "canonical_name": "regulation of tight junction disassembly", "definition": "Any process that modulates the frequency, rate or extent of tight junction disassembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]"}
{"concept_id": "C4235482", "aliases": ["heart cardiac jelly development"], "types": ["T042"], "canonical_name": "cardiac jelly development", "definition": "The process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure. The cardiac jelly is an acellular gelatinous matrix secreted by the myocardium and plays a central role in the septation of the heart. [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10645959, PMID:16314491, PMID:19703439]"}
{"concept_id": "C4235483", "aliases": ["occluding cell junction disassembly", "occluding junction disassembly"], "types": ["T043"], "canonical_name": "tight junction disassembly", "definition": "The disaggregation of an tight junction into its constituent components. [GO_REF:0000079, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]"}
{"concept_id": "C4235484", "aliases": [], "types": ["T043"], "canonical_name": "anterior visceral endoderm cell migration", "definition": "The orderly movement of an anterior visceral endoderm cell from one site to another. [GO_REF:0000091, GOC:TermGenie, PMID:17078044]"}
{"concept_id": "C4235485", "aliases": [], "types": ["T042"], "canonical_name": "allantois development", "definition": "The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, PMID:17440924, PMID:21470579]"}
{"concept_id": "C4235486", "aliases": ["positive regulation of canonical Wnt receptor signalling pathway involved in heart development", "positive regulation of canonical Wnt receptor signaling pathway involved in heart development", "positive regulation of canonical Wnt-activated signaling pathway involved in heart development"], "types": ["T043"], "canonical_name": "positive regulation of canonical Wnt signaling pathway involved in heart development", "definition": "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]"}
{"concept_id": "C4235487", "aliases": ["negative regulation of canonical Wnt receptor signalling pathway involved in heart development", "down-regulation of canonical Wnt receptor signaling pathway involved in heart development", "down regulation of canonical Wnt signaling pathway involved in heart development", "downregulation of canonical Wnt signaling pathway involved in heart development", "down-regulation of canonical Wnt receptor signalling pathway involved in heart development", "down regulation of canonical Wnt-activated signaling pathway involved in heart development", "negative regulation of canonical Wnt receptor signaling pathway involved in heart development", "downregulation of canonical Wnt receptor signalling pathway involved in heart development", "down regulation of canonical Wnt receptor signaling pathway involved in heart development", "down-regulation of canonical Wnt-activated signaling pathway involved in heart development", "down regulation of canonical Wnt receptor signalling pathway involved in heart development", "downregulation of canonical Wnt-activated signaling pathway involved in heart development", "down-regulation of canonical Wnt signaling pathway involved in heart development", "downregulation of canonical Wnt receptor signaling pathway involved in heart development", "negative regulation of canonical Wnt-activated signaling pathway involved in heart development"], "types": ["T043"], "canonical_name": "negative regulation of canonical Wnt signaling pathway involved in heart development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]"}
{"concept_id": "C4235488", "aliases": ["regulation of canonical Wnt receptor signaling pathway involved in heart development", "regulation of canonical Wnt-activated signaling pathway involved in heart development", "regulation of canonical Wnt receptor signalling pathway involved in heart development"], "types": ["T044"], "canonical_name": "regulation of canonical Wnt signaling pathway involved in heart development", "definition": "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]"}
{"concept_id": "C4235489", "aliases": ["positive regulation of VSMC differentiation", "upregulation of vascular smooth muscle cell differentiation", "up-regulation of VSMC differentiation", "up regulation of VSMC differentiation", "upregulation of VSMC differentiation", "up-regulation of vascular associated smooth muscle cell differentiation", "up regulation of vascular associated smooth muscle cell differentiation", "up regulation of vascular smooth muscle cell differentiation", "upregulation of vascular associated smooth muscle cell differentiation", "up-regulation of vascular smooth muscle cell differentiation", "positive regulation of vascular smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of vascular associated smooth muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]"}
{"concept_id": "C4235490", "aliases": ["negative regulation of vascular smooth muscle cell differentiation", "down-regulation of vascular associated smooth muscle cell differentiation", "downregulation of vascular smooth muscle cell differentiation", "down regulation of vascular associated smooth muscle cell differentiation", "down regulation of vascular smooth muscle cell differentiation", "negative regulation of VSMC differentiation", "down regulation of VSMC differentiation", "downregulation of vascular associated smooth muscle cell differentiation", "downregulation of VSMC differentiation", "down-regulation of vascular smooth muscle cell differentiation", "down-regulation of VSMC differentiation"], "types": ["T043"], "canonical_name": "negative regulation of vascular associated smooth muscle cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]"}
{"concept_id": "C4235491", "aliases": ["regulation of vascular smooth muscle cell differentiation", "regulation of VSMC differentiation"], "types": ["T043"], "canonical_name": "regulation of vascular associated smooth muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]"}
{"concept_id": "C4235492", "aliases": ["upregulation of cardioblast proliferation", "up-regulation of cardioblast proliferation", "up regulation of cardioblast proliferation"], "types": ["T043"], "canonical_name": "positive regulation of cardioblast proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097]"}
{"concept_id": "C4235493", "aliases": ["down regulation of cardioblast proliferation", "downregulation of cardioblast proliferation", "down-regulation of cardioblast proliferation"], "types": ["T043"], "canonical_name": "negative regulation of cardioblast proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardioblast proliferation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097]"}
{"concept_id": "C4235494", "aliases": ["calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels"], "types": ["T044"], "canonical_name": "calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "definition": "Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. [GO_REF:0000061, GOC:TermGenie, PMID:18024055]"}
{"concept_id": "C4235495", "aliases": ["Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels", "calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels", "calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration", "calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration"], "types": ["T044"], "canonical_name": "P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "definition": "A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration. [GO_REF:0000061, GOC:TermGenie, PMID:20678993]"}
{"concept_id": "C4235496", "aliases": ["calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels"], "types": ["T043"], "canonical_name": "calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "definition": "Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. [GO_REF:0000061, GOC:TermGenie, PMID:23639769]"}
{"concept_id": "C4235497", "aliases": ["depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels", "depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration", "voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration", "voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration"], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels", "definition": "Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. [GO_REF:0000061, GOC:TermGenie, PMID:20734177]"}
{"concept_id": "C4235498", "aliases": ["Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration", "Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration", "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels", "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration", "Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration", "calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration", "calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration"], "types": ["T044"], "canonical_name": "P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration", "definition": "A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration. [GO_REF:0000061, GOC:TermGenie, PMID:22972962]"}
{"concept_id": "C4235499", "aliases": ["calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels"], "types": ["T044"], "canonical_name": "calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration", "definition": "Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. [GO_REF:0000061, GOC:TermGenie, PMID:22972962, PMID:23255722]"}
{"concept_id": "C4235500", "aliases": ["calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels"], "types": ["T044"], "canonical_name": "calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration", "definition": "Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. [GO_REF:0000061, GOC:TermGenie, PMID:15919193, PMID:23918386]"}
{"concept_id": "C4235501", "aliases": ["upregulation of base-excision repair", "up regulation of BER", "up-regulation of base-excision repair", "up regulation of base-excision repair", "upregulation of BER", "up-regulation of BER", "positive regulation of BER"], "types": ["T045"], "canonical_name": "positive regulation of base-excision repair", "definition": "Any process that activates or increases the frequency, rate or extent of base-excision repair. [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]"}
{"concept_id": "C4235502", "aliases": ["down-regulation of BER", "down-regulation of base-excision repair", "negative regulation of BER", "downregulation of BER", "downregulation of base-excision repair", "down regulation of base-excision repair", "down regulation of BER"], "types": ["T043"], "canonical_name": "negative regulation of base-excision repair", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of base-excision repair. [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]"}
{"concept_id": "C4235503", "aliases": ["regulation of BER"], "types": ["T043"], "canonical_name": "regulation of base-excision repair", "definition": "Any process that modulates the frequency, rate or extent of base-excision repair. [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]"}
{"concept_id": "C4235504", "aliases": ["upregulation of metallopeptidase activity", "up regulation of metallopeptidase activity", "up-regulation of metallopeptidase activity"], "types": ["T044"], "canonical_name": "positive regulation of metallopeptidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of metallopeptidase activity. [GO_REF:0000059, GOC:TermGenie, PMID:26473732]"}
{"concept_id": "C4235505", "aliases": ["downregulation of metallopeptidase activity", "down-regulation of metallopeptidase activity", "down regulation of metallopeptidase activity"], "types": ["T044"], "canonical_name": "negative regulation of metallopeptidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity. [GO_REF:0000059, GOC:TermGenie, PMID:26473732]"}
{"concept_id": "C4235506", "aliases": [], "types": ["T044"], "canonical_name": "regulation of metallopeptidase activity", "definition": "Any process that modulates the frequency, rate or extent of metallopeptidase activity. [GO_REF:0000059, GOC:TermGenie, PMID:26473732]"}
{"concept_id": "C4235507", "aliases": [], "types": ["T043"], "canonical_name": "mitotic spindle pole body organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitotic spindle pole body. [GOC:TermGenie, PMID:24963130]"}
{"concept_id": "C4235508", "aliases": ["up-regulation of Schwann cell proliferation involved in axon regeneration", "upregulation of Schwann cell proliferation involved in axon regeneration", "up regulation of Schwann cell proliferation involved in axon regeneration"], "types": ["T043"], "canonical_name": "positive regulation of Schwann cell proliferation involved in axon regeneration", "definition": "Any process that activates or increases the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241]"}
{"concept_id": "C4235509", "aliases": ["downregulation of Schwann cell proliferation involved in axon regeneration", "down-regulation of Schwann cell proliferation involved in axon regeneration", "down regulation of Schwann cell proliferation involved in axon regeneration"], "types": ["T043"], "canonical_name": "negative regulation of Schwann cell proliferation involved in axon regeneration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241]"}
{"concept_id": "C4235510", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Schwann cell proliferation involved in axon regeneration", "definition": "Any process that modulates the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241]"}
{"concept_id": "C4235511", "aliases": ["up regulation of epithelium regeneration", "up-regulation of epithelium regeneration", "up regulation of regeneration of epithelium", "positive regulation of regeneration of epithelium", "up-regulation of regeneration of epithelium", "upregulation of regeneration of epithelium", "upregulation of epithelium regeneration"], "types": ["T042"], "canonical_name": "positive regulation of epithelium regeneration", "definition": "Any process that activates or increases the frequency, rate or extent of epithelium regeneration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517]"}
{"concept_id": "C4235512", "aliases": ["down regulation of epithelium regeneration", "down-regulation of epithelium regeneration", "down regulation of regeneration of epithelium", "down-regulation of regeneration of epithelium", "negative regulation of regeneration of epithelium", "downregulation of regeneration of epithelium", "downregulation of epithelium regeneration"], "types": ["T040"], "canonical_name": "negative regulation of epithelium regeneration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517]"}
{"concept_id": "C4235513", "aliases": ["regulation of regeneration of epithelium"], "types": ["T042"], "canonical_name": "regulation of epithelium regeneration", "definition": "Any process that modulates the frequency, rate or extent of epithelium regeneration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517]"}
{"concept_id": "C4235514", "aliases": ["placoda otica development"], "types": ["T042"], "canonical_name": "otic placode development", "definition": "The process whose specific outcome is the progression of an otic placode over time, from its formation to the mature structure. [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247]"}
{"concept_id": "C4235515", "aliases": [], "types": ["T043"], "canonical_name": "carboxylic acid transmembrane transport", "definition": "The process in which carboxylic acid is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:10869563]"}
{"concept_id": "C4235516", "aliases": ["regulation of membrane lipid metabolism"], "types": ["T043"], "canonical_name": "regulation of membrane lipid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:25954280]"}
{"concept_id": "C4235517", "aliases": ["autophagic vacuole organization"], "types": ["T043"], "canonical_name": "autophagosome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024]"}
{"concept_id": "C4235518", "aliases": ["upregulation of antifungal innate immune response", "up-regulation of antifungal innate immune response", "up regulation of antifungal innate immune response"], "types": ["T039"], "canonical_name": "positive regulation of antifungal innate immune response", "definition": "Any process that activates or increases the frequency, rate or extent of an antifungal innate immune response. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]"}
{"concept_id": "C4235519", "aliases": ["down-regulation of antifungal innate immune response", "downregulation of antifungal innate immune response", "down regulation of antifungal innate immune response"], "types": ["T039"], "canonical_name": "negative regulation of antifungal innate immune response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]"}
{"concept_id": "C4235520", "aliases": [], "types": ["T039"], "canonical_name": "regulation of antifungal innate immune response", "definition": "Any process that modulates the frequency, rate or extent of an antifungal innate immune response. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]"}
{"concept_id": "C4235521", "aliases": ["up-regulation of membrane repolarization during cardiac muscle cell action potential", "up regulation of membrane repolarization during cardiac muscle cell action potential", "upregulation of membrane repolarization during cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "positive regulation of membrane repolarization during cardiac muscle cell action potential", "definition": "Any process that activates or increases the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]"}
{"concept_id": "C4235522", "aliases": ["downregulation of membrane repolarization during cardiac muscle cell action potential", "down regulation of membrane repolarization during cardiac muscle cell action potential", "down-regulation of membrane repolarization during cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "negative regulation of membrane repolarization during cardiac muscle cell action potential", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]"}
{"concept_id": "C4235523", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane repolarization during cardiac muscle cell action potential", "definition": "Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]"}
{"concept_id": "C4235524", "aliases": ["voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential", "voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential", "voltage gated ion channel activity involved in regulation of post-synaptic membrane potential", "voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential", "voltage gated ion channel activity involved in regulation of postsynaptic membrane potential"], "types": ["T044"], "canonical_name": "voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential", "definition": "Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. [GO_REF:0000061, GOC:TermGenie, ISBN:9780071120005]"}
{"concept_id": "C4235525", "aliases": ["up regulation of membrane depolarization during AV node cell action potential", "up regulation of membrane depolarization during AV node cardiac muscle cell action potential", "up-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential", "up-regulation of membrane depolarization during AV node cell action potential", "up regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential", "up-regulation of membrane depolarization during AV node cardiac muscle cell action potential", "positive regulation of membrane depolarization during AV node cardiac muscle cell action potential", "upregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential", "upregulation of membrane depolarization during AV node cardiac muscle cell action potential", "positive regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential", "upregulation of membrane depolarization during AV node cell action potential"], "types": ["T043"], "canonical_name": "positive regulation of membrane depolarization during AV node cell action potential", "definition": "Any process that activates or increases the frequency, rate or extent of membrane depolarization during AV node cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871]"}
{"concept_id": "C4235526", "aliases": ["down regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential", "down regulation of membrane depolarization during AV node cell action potential", "downregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential", "downregulation of membrane depolarization during AV node cell action potential", "down-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential", "down regulation of membrane depolarization during AV node cardiac muscle cell action potential", "down-regulation of membrane depolarization during AV node cell action potential", "down-regulation of membrane depolarization during AV node cardiac muscle cell action potential", "downregulation of membrane depolarization during AV node cardiac muscle cell action potential", "negative regulation of membrane depolarization during AV node cardiac muscle cell action potential", "negative regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "negative regulation of membrane depolarization during AV node cell action potential", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during AV node cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871]"}
{"concept_id": "C4235527", "aliases": ["regulation of membrane depolarization during AV node cardiac muscle cell action potential", "regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "regulation of membrane depolarization during AV node cell action potential", "definition": "Any process that modulates the frequency, rate or extent of membrane depolarization during AV node cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871]"}
{"concept_id": "C4235528", "aliases": ["up-regulation of membrane repolarization during ventricular cardiac muscle cell action potential", "up regulation of membrane repolarization during ventricular cardiac muscle cell action potential", "upregulation of membrane repolarization during ventricular cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential", "definition": "Any process that activates or increases the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]"}
{"concept_id": "C4235529", "aliases": ["downregulation of membrane repolarization during ventricular cardiac muscle cell action potential", "down-regulation of membrane repolarization during ventricular cardiac muscle cell action potential", "down regulation of membrane repolarization during ventricular cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]"}
{"concept_id": "C4235530", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane repolarization during ventricular cardiac muscle cell action potential", "definition": "Any process that modulates the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]"}
{"concept_id": "C4235531", "aliases": ["upregulation of threonine-tRNA ligase activity", "up-regulation of threonine translase activity", "up-regulation of threonyl-transfer ribonucleic acid synthetase activity", "up regulation of threonyl-tRNA synthetase activity", "upregulation of threonyl ribonucleic synthetase activity", "upregulation of threonine-transfer ribonucleate synthetase activity", "upregulation of threonine translase activity", "upregulation of threonyl-transfer ribonucleic acid synthetase activity", "up regulation of threonyl-transfer ribonucleic acid synthetase activity", "positive regulation of threonyl-transfer RNA synthetase activity", "upregulation of L-threonine:tRNAThr ligase (AMP-forming)", "upregulation of threonyl-tRNA synthetase activity", "up-regulation of threonine-tRNA ligase activity", "up regulation of L-threonine:tRNAThr ligase (AMP-forming)", "up-regulation of threonyl-tRNA synthetase activity", "upregulation of threonyl-transfer RNA synthetase activity", "positive regulation of L-threonine:tRNAThr ligase (AMP-forming)", "positive regulation of threonine translase activity", "up regulation of threonyl-transfer ribonucleate synthetase activity", "up-regulation of threonyl-transfer RNA synthetase activity", "up-regulation of threonyl ribonucleic synthetase activity", "positive regulation of threonyl-tRNA synthetase activity", "up regulation of threonyl-transfer RNA synthetase activity", "positive regulation of threonine-transfer ribonucleate synthetase activity", "positive regulation of threonyl-transfer ribonucleate synthetase activity", "up-regulation of threonine-transfer ribonucleate synthetase activity", "positive regulation of threonyl ribonucleic synthetase activity", "up-regulation of L-threonine:tRNAThr ligase (AMP-forming)", "up regulation of threonyl ribonucleic synthetase activity", "up regulation of threonine-tRNA ligase activity", "up regulation of threonine-transfer ribonucleate synthetase activity", "up regulation of threonine translase activity", "positive regulation of threonyl-transfer ribonucleic acid synthetase activity", "upregulation of threonyl-transfer ribonucleate synthetase activity", "up-regulation of threonyl-transfer ribonucleate synthetase activity"], "types": ["T044"], "canonical_name": "positive regulation of threonine-tRNA ligase activity", "definition": "Any process that activates or increases the frequency, rate or extent of threonine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:8049265]"}
{"concept_id": "C4235532", "aliases": ["down-regulation of threonyl-tRNA synthetase activity", "down-regulation of threonine translase activity", "negative regulation of threonyl-transfer ribonucleate synthetase activity", "down regulation of threonine-transfer ribonucleate synthetase activity", "down-regulation of L-threonine:tRNAThr ligase (AMP-forming)", "down regulation of threonine-tRNA ligase activity", "down regulation of L-threonine:tRNAThr ligase (AMP-forming)", "down-regulation of threonyl ribonucleic synthetase activity", "downregulation of threonyl-transfer ribonucleic acid synthetase activity", "negative regulation of threonyl-transfer ribonucleic acid synthetase activity", "down regulation of threonyl-transfer RNA synthetase activity", "negative regulation of threonyl-tRNA synthetase activity", "downregulation of threonyl-tRNA synthetase activity", "negative regulation of threonine-transfer ribonucleate synthetase activity", "downregulation of L-threonine:tRNAThr ligase (AMP-forming)", "negative regulation of threonine translase activity", "down-regulation of threonyl-transfer ribonucleate synthetase activity", "down-regulation of threonyl-transfer ribonucleic acid synthetase activity", "negative regulation of L-threonine:tRNAThr ligase (AMP-forming)", "downregulation of threonine-tRNA ligase activity", "down-regulation of threonine-transfer ribonucleate synthetase activity", "downregulation of threonine translase activity", "down regulation of threonyl-tRNA synthetase activity", "downregulation of threonine-transfer ribonucleate synthetase activity", "downregulation of threonyl-transfer ribonucleate synthetase activity", "negative regulation of threonyl ribonucleic synthetase activity", "down regulation of threonyl ribonucleic synthetase activity", "down regulation of threonyl-transfer ribonucleate synthetase activity", "downregulation of threonyl ribonucleic synthetase activity", "downregulation of threonyl-transfer RNA synthetase activity", "down-regulation of threonine-tRNA ligase activity", "down regulation of threonyl-transfer ribonucleic acid synthetase activity", "down regulation of threonine translase activity", "negative regulation of threonyl-transfer RNA synthetase activity", "down-regulation of threonyl-transfer RNA synthetase activity"], "types": ["T044"], "canonical_name": "negative regulation of threonine-tRNA ligase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of threonine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:8049265]"}
{"concept_id": "C4235533", "aliases": ["regulation of threonyl-tRNA synthetase activity", "regulation of threonyl-transfer ribonucleic acid synthetase activity", "regulation of threonine translase activity", "regulation of L-threonine:tRNAThr ligase (AMP-forming)", "regulation of threonine-transfer ribonucleate synthetase activity", "regulation of threonyl ribonucleic synthetase activity", "regulation of threonyl-transfer ribonucleate synthetase activity", "regulation of threonyl-transfer RNA synthetase activity"], "types": ["T044"], "canonical_name": "regulation of threonine-tRNA ligase activity", "definition": "Any process that modulates the frequency, rate or extent of threonine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:8049265]"}
{"concept_id": "C4235534", "aliases": ["positive regulation of MetRS activity", "up-regulation of methionyl-tRNA synthetase activity", "positive regulation of methionine translase activity", "up-regulation of methionyl-transfer ribonucleic acid synthetase activity", "up regulation of methionine-tRNA ligase activity", "up regulation of methionyl-tRNA synthetase activity", "up-regulation of MetRS activity", "positive regulation of methionyl-transfer ribonucleate synthetase activity", "up-regulation of methionyl-transfer ribonucleate synthetase activity", "up-regulation of L-methionine:tRNAMet ligase (AMP-forming)", "positive regulation of L-methionine:tRNAMet ligase (AMP-forming)", "up-regulation of methionine-tRNA ligase activity", "upregulation of methionyl-transfer ribonucleate synthetase activity", "up regulation of MetRS activity", "upregulation of methionyl-tRNA synthetase activity", "up-regulation of methionyl-transfer RNA synthetase activity", "up regulation of methionyl-transfer ribonucleate synthetase activity", "positive regulation of methionyl-tRNA synthetase activity", "upregulation of methionine-tRNA ligase activity", "up regulation of methionine translase activity", "upregulation of methionyl-transfer RNA synthetase activity", "upregulation of MetRS activity", "positive regulation of methionyl-transfer ribonucleic acid synthetase activity", "up regulation of methionyl-transfer RNA synthetase activity", "up-regulation of methionine translase activity", "positive regulation of methionyl-transfer RNA synthetase activity", "up regulation of L-methionine:tRNAMet ligase (AMP-forming)", "upregulation of methionyl-transfer ribonucleic acid synthetase activity", "upregulation of methionine translase activity", "up regulation of methionyl-transfer ribonucleic acid synthetase activity", "upregulation of L-methionine:tRNAMet ligase (AMP-forming)"], "types": ["T044"], "canonical_name": "positive regulation of methionine-tRNA ligase activity", "definition": "Any process that activates or increases the frequency, rate or extent of methionine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:1665486]"}
{"concept_id": "C4235535", "aliases": ["negative regulation of methionyl-tRNA synthetase activity", "negative regulation of methionyl-transfer ribonucleic acid synthetase activity", "down-regulation of methionine translase activity", "down regulation of methionyl-transfer ribonucleic acid synthetase activity", "downregulation of methionine translase activity", "downregulation of methionine-tRNA ligase activity", "downregulation of methionyl-transfer RNA synthetase activity", "down regulation of methionyl-tRNA synthetase activity", "down regulation of methionine-tRNA ligase activity", "downregulation of MetRS activity", "negative regulation of L-methionine:tRNAMet ligase (AMP-forming)", "downregulation of methionyl-transfer ribonucleate synthetase activity", "negative regulation of MetRS activity", "negative regulation of methionyl-transfer ribonucleate synthetase activity", "negative regulation of methionyl-transfer RNA synthetase activity", "down regulation of methionine translase activity", "down regulation of L-methionine:tRNAMet ligase (AMP-forming)", "down-regulation of methionyl-tRNA synthetase activity", "downregulation of L-methionine:tRNAMet ligase (AMP-forming)", "down-regulation of MetRS activity", "down regulation of methionyl-transfer RNA synthetase activity", "downregulation of methionyl-transfer ribonucleic acid synthetase activity", "down-regulation of methionyl-transfer ribonucleate synthetase activity", "down-regulation of L-methionine:tRNAMet ligase (AMP-forming)", "down-regulation of methionyl-transfer ribonucleic acid synthetase activity", "down regulation of MetRS activity", "downregulation of methionyl-tRNA synthetase activity", "negative regulation of methionine translase activity", "down-regulation of methionine-tRNA ligase activity", "down regulation of methionyl-transfer ribonucleate synthetase activity", "down-regulation of methionyl-transfer RNA synthetase activity"], "types": ["T044"], "canonical_name": "negative regulation of methionine-tRNA ligase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of methionine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:1665486]"}
{"concept_id": "C4235536", "aliases": ["regulation of methionyl-tRNA synthetase activity", "regulation of methionyl-transfer ribonucleic acid synthetase activity", "regulation of methionyl-transfer ribonucleate synthetase activity", "regulation of MetRS activity", "regulation of methionyl-transfer RNA synthetase activity", "regulation of L-methionine:tRNAMet ligase (AMP-forming)", "regulation of methionine translase activity"], "types": ["T044"], "canonical_name": "regulation of methionine-tRNA ligase activity", "definition": "Any process that modulates the frequency, rate or extent of methionine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:1665486]"}
{"concept_id": "C4235537", "aliases": ["upregulation of L-isoleucine:tRNAIle ligase (AMP-forming)", "up regulation of isoleucine-tRNA synthetase activity", "up-regulation of isoleucyl-transfer RNA synthetase activity", "up-regulation of isoleucine-transfer RNA ligase activity", "positive regulation of isoleucine-transfer RNA ligase activity", "up-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)", "positive regulation of L-isoleucine:tRNAIle ligase (AMP-forming)", "up-regulation of isoleucyl-tRNA synthetase activity", "up-regulation of isoleucine translase activity", "up regulation of isoleucine-tRNA ligase activity", "up regulation of isoleucine-transfer RNA ligase activity", "up-regulation of isoleucyl-transfer ribonucleate synthetase activity", "upregulation of isoleucyl-transfer ribonucleate synthetase activity", "positive regulation of isoleucyl-tRNA synthetase activity", "up regulation of isoleucyl-transfer ribonucleate synthetase activity", "up regulation of L-isoleucine:tRNAIle ligase (AMP-forming)", "positive regulation of isoleucine-tRNA synthetase activity", "upregulation of isoleucyl-tRNA synthetase activity", "up regulation of isoleucine translase activity", "upregulation of isoleucine-tRNA synthetase activity", "upregulation of isoleucine-tRNA ligase activity", "positive regulation of isoleucine translase activity", "positive regulation of isoleucyl-transfer RNA synthetase activity", "up regulation of isoleucyl-transfer RNA synthetase activity", "up regulation of isoleucyl-tRNA synthetase activity", "upregulation of isoleucyl-transfer RNA synthetase activity", "positive regulation of isoleucyl-transfer ribonucleate synthetase activity", "upregulation of isoleucine translase activity", "up-regulation of isoleucine-tRNA synthetase activity", "upregulation of isoleucine-transfer RNA ligase activity", "up-regulation of isoleucine-tRNA ligase activity"], "types": ["T044"], "canonical_name": "positive regulation of isoleucine-tRNA ligase activity", "definition": "Any process that activates or increases the frequency, rate or extent of isoleucine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:1665486]"}
{"concept_id": "C4235538", "aliases": ["down-regulation of isoleucine translase activity", "downregulation of isoleucine-tRNA ligase activity", "downregulation of isoleucine translase activity", "down-regulation of isoleucyl-transfer ribonucleate synthetase activity", "negative regulation of isoleucyl-transfer ribonucleate synthetase activity", "downregulation of isoleucyl-transfer ribonucleate synthetase activity", "down-regulation of isoleucyl-transfer RNA synthetase activity", "downregulation of isoleucyl-transfer RNA synthetase activity", "down regulation of isoleucine-transfer RNA ligase activity", "negative regulation of isoleucine-transfer RNA ligase activity", "down-regulation of isoleucine-tRNA synthetase activity", "down-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)", "down-regulation of isoleucine-tRNA ligase activity", "down regulation of isoleucyl-transfer ribonucleate synthetase activity", "downregulation of L-isoleucine:tRNAIle ligase (AMP-forming)", "downregulation of isoleucine-tRNA synthetase activity", "negative regulation of L-isoleucine:tRNAIle ligase (AMP-forming)", "down-regulation of isoleucyl-tRNA synthetase activity", "down regulation of isoleucyl-transfer RNA synthetase activity", "down regulation of L-isoleucine:tRNAIle ligase (AMP-forming)", "negative regulation of isoleucine-tRNA synthetase activity", "downregulation of isoleucine-transfer RNA ligase activity", "down regulation of isoleucyl-tRNA synthetase activity", "down regulation of isoleucine translase activity", "downregulation of isoleucyl-tRNA synthetase activity", "negative regulation of isoleucyl-transfer RNA synthetase activity", "down regulation of isoleucine-tRNA ligase activity", "negative regulation of isoleucyl-tRNA synthetase activity", "down regulation of isoleucine-tRNA synthetase activity", "negative regulation of isoleucine translase activity", "down-regulation of isoleucine-transfer RNA ligase activity"], "types": ["T044"], "canonical_name": "negative regulation of isoleucine-tRNA ligase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of isoleucine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:1665486]"}
{"concept_id": "C4235539", "aliases": ["regulation of isoleucine translase activity", "regulation of isoleucyl-tRNA synthetase activity", "regulation of isoleucyl-transfer RNA synthetase activity", "regulation of isoleucine-transfer RNA ligase activity", "regulation of isoleucyl-transfer ribonucleate synthetase activity", "regulation of isoleucine-tRNA synthetase activity", "regulation of L-isoleucine:tRNAIle ligase (AMP-forming)"], "types": ["T044"], "canonical_name": "regulation of isoleucine-tRNA ligase activity", "definition": "Any process that modulates the frequency, rate or extent of isoleucine-tRNA ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:1665486]"}
{"concept_id": "C4235540", "aliases": ["positive regulation of de novo NAD biosynthetic process from tryptophan"], "types": ["T044"], "canonical_name": "positive regulation of 'de novo' NAD biosynthetic process from tryptophan", "definition": "Any process that activates or increases the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235541", "aliases": ["down regulation of 'de novo' NAD biosynthetic process from tryptophan", "negative regulation of de novo NAD biosynthetic process from tryptophan", "down regulation of de novo NAD biosynthetic process from tryptophan", "downregulation of 'de novo' NAD biosynthetic process from tryptophan", "down-regulation of de novo NAD biosynthetic process from tryptophan", "downregulation of de novo NAD biosynthetic process from tryptophan", "down-regulation of 'de novo' NAD biosynthetic process from tryptophan"], "types": ["T044"], "canonical_name": "negative regulation of 'de novo' NAD biosynthetic process from tryptophan", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]"}
{"concept_id": "C4235542", "aliases": [], "types": ["T043"], "canonical_name": "transmembrane phosphate ion transport from cytosol to vacuole", "definition": "The directed movement of phosphate ions from the cytosol across the vacuolar membrane and into the vacuolar lumen. [GO_REF:0000078, GOC:TermGenie, PMID:26554016]"}
{"concept_id": "C4235544", "aliases": ["negative regulation of L-lysine import into cell", "negative regulation of lysine uptake", "downregulation of L-lysine import into cell", "down regulation of L-lysine import into cell", "down-regulation of L-lysine import into cell"], "types": ["T044"], "canonical_name": "negative regulation of L-lysine import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-lysine import into cell. [GO_REF:0000058, GOC:TermGenie, PMID:7499219]"}
{"concept_id": "C4235545", "aliases": ["regulation of L-lysine import into cell", "regulation of lysine uptake"], "types": ["T044"], "canonical_name": "regulation of L-lysine import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of L-lysine import into cell. [GO_REF:0000058, GOC:TermGenie, PMID:7499219]"}
{"concept_id": "C4235546", "aliases": ["up-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation", "upregulation of epithelial to mesenchymal transition involved in endocardial cushion formation", "up regulation of epithelial to mesenchymal transition involved in endocardial cushion formation"], "types": ["T043"], "canonical_name": "positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation", "definition": "Any process that activates or increases the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]"}
{"concept_id": "C4235547", "aliases": ["down-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation", "downregulation of epithelial to mesenchymal transition involved in endocardial cushion formation", "down regulation of epithelial to mesenchymal transition involved in endocardial cushion formation"], "types": ["T043"], "canonical_name": "negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]"}
{"concept_id": "C4235548", "aliases": [], "types": ["T042"], "canonical_name": "regulation of epithelial to mesenchymal transition involved in endocardial cushion formation", "definition": "Any process that modulates the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]"}
{"concept_id": "C4235549", "aliases": ["picolinate biosynthetic process", "picolinic acid anabolism", "picolinic acid synthesis", "picolinic acid formation", "picolinate biosynthesis", "picolinic acid biosynthesis"], "types": ["T044"], "canonical_name": "picolinic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of picolinic acid. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166]"}
{"concept_id": "C4235550", "aliases": ["picolinate metabolism", "picolinic acid metabolism"], "types": ["T044"], "canonical_name": "picolinic acid metabolic process", "definition": "The chemical reactions and pathways involving picolinic acid. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166]"}
{"concept_id": "C4235551", "aliases": ["upregulation of membrane repolarization during atrial cardiac muscle cell action potential", "up regulation of membrane repolarization during atrial cardiac muscle cell action potential", "up-regulation of membrane repolarization during atrial cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "positive regulation of membrane repolarization during atrial cardiac muscle cell action potential", "definition": "Any process that activates or increases the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446]"}
{"concept_id": "C4235552", "aliases": ["down-regulation of membrane repolarization during atrial cardiac muscle cell action potential", "down regulation of membrane repolarization during atrial cardiac muscle cell action potential", "downregulation of membrane repolarization during atrial cardiac muscle cell action potential"], "types": ["T043"], "canonical_name": "negative regulation of membrane repolarization during atrial cardiac muscle cell action potential", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446]"}
{"concept_id": "C4235553", "aliases": [], "types": ["T043"], "canonical_name": "regulation of membrane repolarization during atrial cardiac muscle cell action potential", "definition": "Any process that modulates the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446]"}
{"concept_id": "C4235554", "aliases": ["upregulation of leukocyte adhesion to arterial endothelial cell", "up-regulation of leukocyte adhesion to arterial endothelial cell", "up regulation of leukocyte adhesion to arterial endothelial cell"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte adhesion to arterial endothelial cell", "definition": "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480]"}
{"concept_id": "C4235555", "aliases": ["downregulation of leukocyte adhesion to arterial endothelial cell", "down regulation of leukocyte adhesion to arterial endothelial cell", "down-regulation of leukocyte adhesion to arterial endothelial cell"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte adhesion to arterial endothelial cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480]"}
{"concept_id": "C4235556", "aliases": [], "types": ["T043"], "canonical_name": "regulation of leukocyte adhesion to arterial endothelial cell", "definition": "Any process that modulates the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480]"}
{"concept_id": "C4235557", "aliases": ["up regulation of leukocyte adhesion to vascular endothelial cell", "up-regulation of leukocyte adhesion to vascular endothelial cell", "upregulation of leukocyte adhesion to vascular endothelial cell"], "types": ["T043"], "canonical_name": "positive regulation of leukocyte adhesion to vascular endothelial cell", "definition": "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]"}
{"concept_id": "C4235558", "aliases": ["down regulation of leukocyte adhesion to vascular endothelial cell", "down-regulation of leukocyte adhesion to vascular endothelial cell", "downregulation of leukocyte adhesion to vascular endothelial cell"], "types": ["T043"], "canonical_name": "negative regulation of leukocyte adhesion to vascular endothelial cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]"}
{"concept_id": "C4235559", "aliases": [], "types": ["T043"], "canonical_name": "regulation of leukocyte adhesion to vascular endothelial cell", "definition": "Any process that modulates the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]"}
{"concept_id": "C4235560", "aliases": ["positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway", "positive regulation of dopamine receptor, adenylyl cyclase inhibiting pathway", "positive regulation of dopamine receptor, adenylate cyclase inhibiting pathway", "positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway"], "types": ["T043"], "canonical_name": "positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]"}
{"concept_id": "C4235561", "aliases": ["negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway", "negative regulation of dopamine receptor, adenylyl cyclase inhibiting pathway", "negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway", "negative regulation of dopamine receptor, adenylate cyclase inhibiting pathway"], "types": ["T044"], "canonical_name": "negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]"}
{"concept_id": "C4235562", "aliases": ["regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway", "regulation of dopamine receptor, adenylate cyclase inhibiting pathway", "regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway", "regulation of dopamine receptor, adenylyl cyclase inhibiting pathway"], "types": ["T043"], "canonical_name": "regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]"}
{"concept_id": "C4235563", "aliases": ["up-regulation of endothelial cell activation", "upregulation of endothelial cell activation", "up regulation of endothelial cell activation"], "types": ["T043"], "canonical_name": "positive regulation of endothelial cell activation", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial cell activation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]"}
{"concept_id": "C4235564", "aliases": ["down regulation of endothelial cell activation", "downregulation of endothelial cell activation", "down-regulation of endothelial cell activation"], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]"}
{"concept_id": "C4235565", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelial cell activation", "definition": "Any process that modulates the frequency, rate or extent of endothelial cell activation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]"}
{"concept_id": "C4235566", "aliases": ["positive regulation of quinolinate synthesis", "upregulation of quinolinate biosynthetic process", "up-regulation of quinolinate anabolism", "up regulation of quinolinate biosynthesis", "positive regulation of quinolinate biosynthesis", "up regulation of quinolinate synthesis", "positive regulation of quinolinate anabolism", "upregulation of quinolinate synthesis", "upregulation of quinolinate biosynthesis", "up regulation of quinolinate formation", "upregulation of quinolinate formation", "up-regulation of quinolinate biosynthetic process", "up regulation of quinolinate anabolism", "up regulation of quinolinate biosynthetic process", "up-regulation of quinolinate synthesis", "positive regulation of quinolinate formation", "upregulation of quinolinate anabolism", "up-regulation of quinolinate biosynthesis", "up-regulation of quinolinate formation"], "types": ["T044"], "canonical_name": "positive regulation of quinolinate biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of quinolinate biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235567", "aliases": ["negative regulation of quinolinate biosynthesis", "down-regulation of quinolinate biosynthesis", "negative regulation of quinolinate synthesis", "down regulation of quinolinate biosynthesis", "downregulation of quinolinate biosynthesis", "down regulation of quinolinate anabolism", "negative regulation of quinolinate formation", "downregulation of quinolinate anabolism", "down-regulation of quinolinate anabolism", "down regulation of quinolinate synthesis", "negative regulation of quinolinate anabolism", "down regulation of quinolinate formation", "down-regulation of quinolinate synthesis", "downregulation of quinolinate biosynthetic process", "downregulation of quinolinate synthesis", "down-regulation of quinolinate formation", "down-regulation of quinolinate biosynthetic process", "down regulation of quinolinate biosynthetic process", "downregulation of quinolinate formation"], "types": ["T044"], "canonical_name": "negative regulation of quinolinate biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of quinolinate biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]"}
{"concept_id": "C4235568", "aliases": ["regulation of quinolinate biosynthesis", "regulation of quinolinate anabolism", "regulation of quinolinate formation", "regulation of quinolinate synthesis"], "types": ["T044"], "canonical_name": "regulation of quinolinate biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of quinolinate biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]"}
{"concept_id": "C4235569", "aliases": ["transmembrane glycine transport from cytosol to mitochondrion"], "types": ["T043"], "canonical_name": "glycine import into mitochondrion", "definition": "The process in which glycine is transported from the cytosol into the mitochondrial matrix. [GO_REF:0000078, GOC:TermGenie, PMID:26821380]"}
{"concept_id": "C4235570", "aliases": [], "types": ["T043"], "canonical_name": "sucrose transmembrane transport", "definition": "The process in which sucrose is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:11136464]"}
{"concept_id": "C4235571", "aliases": [], "types": ["T043"], "canonical_name": "maltose transmembrane transport", "definition": "The process in which maltose is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:11136464]"}
{"concept_id": "C4235572", "aliases": ["upregulation of endosome organisation", "upregulation of endosome organization", "up-regulation of endosome organisation", "up regulation of endosome organisation", "up regulation of endosome organization", "up-regulation of endosome organization", "positive regulation of endosome organisation"], "types": ["T043"], "canonical_name": "positive regulation of endosome organization", "definition": "Any process that activates or increases the frequency, rate or extent of endosome organization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]"}
{"concept_id": "C4235573", "aliases": ["down regulation of endosome organisation", "downregulation of endosome organization", "downregulation of endosome organisation", "down regulation of endosome organization", "negative regulation of endosome organisation", "down-regulation of endosome organisation", "down-regulation of endosome organization"], "types": ["T043"], "canonical_name": "negative regulation of endosome organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endosome organization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]"}
{"concept_id": "C4235574", "aliases": ["regulation of endosome organisation"], "types": ["T043"], "canonical_name": "regulation of endosome organization", "definition": "Any process that modulates the frequency, rate or extent of endosome organization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]"}
{"concept_id": "C4235575", "aliases": [], "types": ["T043"], "canonical_name": "lymphatic endothelial cell migration", "definition": "The orderly movement of a lymphatic endothelial cell from one site to another in the wall of a lymphatic vessel. [GO_REF:0000091, GOC:TermGenie, PMID:25745057]"}
{"concept_id": "C4235576", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to bleomycin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:11553781]"}
{"concept_id": "C4235577", "aliases": [], "types": ["T043"], "canonical_name": "response to bleomycin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:11553781]"}
{"concept_id": "C4235578", "aliases": ["up-regulation of viral protein biosynthetic process", "up-regulation of viral protein biosynthesis", "up regulation of viral protein formation", "up-regulation of viral translation", "up regulation of viral protein biosynthesis", "up regulation of viral protein synthesis", "positive regulation of viral protein synthesis", "upregulation of viral protein formation", "positive regulation of viral protein biosynthetic process", "positive regulation of viral protein biosynthesis", "up regulation of viral translation", "upregulation of viral translation", "upregulation of viral protein biosynthesis", "upregulation of viral protein synthesis", "up regulation of viral protein anabolism", "up-regulation of viral protein anabolism", "up-regulation of viral protein formation", "up-regulation of viral protein synthesis", "positive regulation of viral protein formation", "upregulation of viral protein anabolism", "up regulation of viral protein biosynthetic process", "upregulation of viral protein biosynthetic process", "positive regulation of viral protein anabolism"], "types": ["T045"], "canonical_name": "positive regulation of viral translation", "definition": "Any process that activates or increases the frequency, rate or extent of viral translation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]"}
{"concept_id": "C4235579", "aliases": ["negative regulation of viral protein synthesis", "down-regulation of viral protein anabolism", "down-regulation of viral translation", "downregulation of viral protein biosynthetic process", "down regulation of viral protein anabolism", "down-regulation of viral protein formation", "downregulation of viral protein biosynthesis", "downregulation of viral protein synthesis", "down regulation of viral translation", "down regulation of viral protein biosynthetic process", "down regulation of viral protein synthesis", "down-regulation of viral protein biosynthesis", "downregulation of viral translation", "negative regulation of viral protein biosynthesis", "downregulation of viral protein anabolism", "negative regulation of viral protein biosynthetic process", "negative regulation of viral protein formation", "down regulation of viral protein biosynthesis", "downregulation of viral protein formation", "down regulation of viral protein formation", "negative regulation of viral protein anabolism", "down-regulation of viral protein biosynthetic process", "down-regulation of viral protein synthesis"], "types": ["T045"], "canonical_name": "negative regulation of viral translation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of viral translation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]"}
{"concept_id": "C4235580", "aliases": ["regulation of viral protein formation", "regulation of viral protein biosynthetic process", "regulation of viral protein synthesis", "regulation of viral protein anabolism", "regulation of viral protein biosynthesis"], "types": ["T043"], "canonical_name": "regulation of viral translation", "definition": "Any process that modulates the frequency, rate or extent of viral translation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]"}
{"concept_id": "C4235581", "aliases": ["brush border formation"], "types": ["T043"], "canonical_name": "brush border assembly", "definition": "The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border. [GO_REF:0000079, GOC:lb, GOC:TermGenie, PMID:24725409]"}
{"concept_id": "C4235582", "aliases": ["slow-twitch muscle cell migration"], "types": ["T043"], "canonical_name": "slow muscle cell migration", "definition": "The orderly movement of a slow muscle cell from one site to another. [GO_REF:0000091, GOC:TermGenie, GOC:ymb, PMID:14667409, PMID:15572133, PMID:25534553]"}
{"concept_id": "C4235583", "aliases": ["up regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation", "upregulation of sister kinetochore mono-orientation", "up regulation of monopolar attachment", "upregulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation", "positive regulation of sister kinetochore mono-orientation", "upregulation of attachment of spindle microtubules to kinetochore involved in meiosis I", "upregulation of monopolar attachment", "up-regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation", "positive regulation of monopolar attachment", "up-regulation of attachment of spindle microtubules to kinetochore involved in meiosis I", "positive regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation", "up-regulation of sister kinetochore mono-orientation", "positive regulation of attachment of spindle microtubules to kinetochore involved in meiosis I", "up regulation of sister kinetochore mono-orientation", "up regulation of attachment of spindle microtubules to kinetochore involved in meiosis I", "up-regulation of monopolar attachment"], "types": ["T043"], "canonical_name": "positive regulation of monopolar spindle attachment to meiosis I kinetochore", "definition": "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation. [GO_REF:0000058, GOC:TermGenie, PMID:23770679]"}
{"concept_id": "C4235584", "aliases": ["regulation of sister kinetochore mono-orientation", "regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation", "regulation of monopolar attachment", "regulation of attachment of spindle microtubules to kinetochore involved in meiosis I"], "types": ["T043"], "canonical_name": "regulation of monopolar spindle attachment to meiosis I kinetochore", "definition": "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:21920317, PMID:23770679]"}
{"concept_id": "C4235585", "aliases": ["upregulation of vitamin E synthesis", "up-regulation of tocopherol biosynthetic process", "positive regulation of vitamin E biosynthesis", "positive regulation of tocopherol biosynthetic process", "up regulation of vitamin E formation", "up regulation of vitamin E biosynthetic process", "upregulation of vitamin E biosynthetic process", "up regulation of tocopherol biosynthetic process", "up-regulation of vitamin E biosynthetic process", "up-regulation of vitamin E synthesis", "up-regulation of vitamin E biosynthesis", "upregulation of vitamin E biosynthesis", "up regulation of vitamin E biosynthesis", "up-regulation of vitamin E formation", "upregulation of vitamin E formation", "upregulation of tocopherol biosynthetic process", "up regulation of vitamin E anabolism", "up-regulation of vitamin E anabolism", "upregulation of vitamin E anabolism", "up regulation of vitamin E synthesis", "up-regulation of tocopherol biosynthesis", "positive regulation of tocopherol biosynthesis", "up regulation of tocopherol biosynthesis", "positive regulation of vitamin E synthesis", "positive regulation of vitamin E anabolism", "upregulation of tocopherol biosynthesis", "positive regulation of vitamin E formation"], "types": ["T044"], "canonical_name": "positive regulation of vitamin E biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of vitamin E biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:20823244]"}
{"concept_id": "C4235586", "aliases": ["regulation of vitamin E anabolism", "regulation of vitamin E formation", "regulation of vitamin E biosynthesis", "regulation of tocopherol biosynthetic process", "regulation of tocopherol biosynthesis", "regulation of vitamin E synthesis"], "types": ["T044"], "canonical_name": "regulation of vitamin E biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of vitamin E biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:20823244]"}
{"concept_id": "C4235587", "aliases": ["positive regulation of phytol anabolism", "up-regulation of phytol anabolism", "up regulation of phytol biosynthesis", "up-regulation of phytol formation", "up-regulation of phytol synthesis", "upregulation of phytol biosynthesis", "up regulation of phytol biosynthetic process", "up-regulation of phytol biosynthesis", "up regulation of phytol anabolism", "upregulation of phytol formation", "upregulation of phytol biosynthetic process", "positive regulation of phytol formation", "upregulation of phytol synthesis", "up-regulation of phytol biosynthetic process", "up regulation of phytol synthesis", "up regulation of phytol formation", "positive regulation of phytol synthesis", "upregulation of phytol anabolism", "positive regulation of phytol biosynthesis"], "types": ["T044"], "canonical_name": "positive regulation of phytol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of phytol biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:24275650]"}
{"concept_id": "C4235588", "aliases": ["regulation of phytol formation", "regulation of phytol biosynthesis", "regulation of phytol anabolism", "regulation of phytol synthesis"], "types": ["T043"], "canonical_name": "regulation of phytol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of phytol biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:24275650]"}
{"concept_id": "C4235589", "aliases": [], "types": ["T043"], "canonical_name": "plastid to vacuole vesicle-mediated transport", "definition": "The vesicle-mediated and directed movement of substances from plastid to vacuole. [GO_REF:0000076, GOC:TermGenie, PMID:25281689]"}
{"concept_id": "C4235590", "aliases": ["quiescent center structural organization"], "types": ["T040"], "canonical_name": "quiescent center organization", "definition": "The process that contributes to the act of creating the structural organization of the quiescent center. This process pertains to the physical shaping of a rudimentary structure. [GO_REF:0000084, GOC:TermGenie, PMID:21233333]"}
{"concept_id": "C4235591", "aliases": ["up regulation of cytochrome-c oxidase activity", "positive regulation of NADH cytochrome c oxidase", "up-regulation of NADH cytochrome c oxidase", "positive regulation of cytochrome c oxidase activity", "up regulation of NADH cytochrome c oxidase", "upregulation of cytochrome-c oxidase activity", "upregulation of cytochrome c oxidase activity", "up-regulation of cytochrome c oxidase activity", "up regulation of cytochrome c oxidase activity", "upregulation of NADH cytochrome c oxidase", "up-regulation of cytochrome-c oxidase activity"], "types": ["T044"], "canonical_name": "positive regulation of cytochrome-c oxidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity. [GO_REF:0000059, GOC:TermGenie, PMID:26734017]"}
{"concept_id": "C4235592", "aliases": ["regulation of NADH cytochrome c oxidase", "regulation of cytochrome c oxidase activity"], "types": ["T044"], "canonical_name": "regulation of cytochrome-c oxidase activity", "definition": "Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity. [GO_REF:0000059, GOC:TermGenie, PMID:26734017]"}
{"concept_id": "C4235593", "aliases": ["up-regulation of DA neurogenesis from midbrain floor plate", "upregulation of mDA neuron differentiation", "up regulation of DA neurogenesis from midbrain floor plate", "up-regulation of midbrain dopaminergic neuron production", "upregulation of DA neurogenesis from midbrain floor plate", "up regulation of midbrain dopaminergic neuron differentiation", "up-regulation of midbrain dopaminergic neuron differentiation", "positive regulation of mDA neuron differentiation", "positive regulation of midbrain dopaminergic neuron production", "up regulation of midbrain dopaminergic neuron production", "up regulation of midbrain DA neurogenesis", "up-regulation of midbrain DA neurogenesis", "upregulation of midbrain DA neurogenesis", "up regulation of mDA neuron differentiation", "positive regulation of DA neurogenesis from midbrain floor plate", "positive regulation of midbrain DA neurogenesis", "up-regulation of mDA neuron differentiation", "upregulation of midbrain dopaminergic neuron production", "upregulation of midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "positive regulation of midbrain dopaminergic neuron differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]"}
{"concept_id": "C4235594", "aliases": ["downregulation of DA neurogenesis from midbrain floor plate", "down-regulation of DA neurogenesis from midbrain floor plate", "down-regulation of midbrain dopaminergic neuron differentiation", "downregulation of midbrain dopaminergic neuron production", "down regulation of midbrain dopaminergic neuron differentiation", "downregulation of midbrain DA neurogenesis", "down-regulation of midbrain DA neurogenesis", "negative regulation of midbrain DA neurogenesis", "downregulation of mDA neuron differentiation", "negative regulation of DA neurogenesis from midbrain floor plate", "down regulation of midbrain DA neurogenesis", "down-regulation of mDA neuron differentiation", "negative regulation of midbrain dopaminergic neuron production", "down regulation of DA neurogenesis from midbrain floor plate", "down regulation of mDA neuron differentiation", "negative regulation of mDA neuron differentiation", "down-regulation of midbrain dopaminergic neuron production", "downregulation of midbrain dopaminergic neuron differentiation", "down regulation of midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "negative regulation of midbrain dopaminergic neuron differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235595", "aliases": ["regulation of midbrain dopaminergic neuron production", "regulation of midbrain DA neurogenesis", "regulation of mDA neuron differentiation", "regulation of DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "regulation of midbrain dopaminergic neuron differentiation", "definition": "Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]"}
{"concept_id": "C4235596", "aliases": ["Wnt signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation", "Wnt receptor signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation", "planar cell polarity pathway involved in midbrain DA neurogenesis", "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation", "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis", "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis", "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation", "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production", "Wnt receptor signalling pathway, planar cell polarity pathway involved in mDA neuron differentiation", "Wnt receptor signalling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate", "Wnt signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis", "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation", "Wnt signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate", "PCP pathway involved in midbrain dopaminergic neuron production", "PCP pathway involved in mDA neuron differentiation", "PCP pathway involved in DA neurogenesis from midbrain floor plate", "planar cell polarity pathway involved in midbrain dopaminergic neuron production", "planar cell polarity pathway involved in mDA neuron differentiation", "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production", "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation", "Wnt-activated signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation", "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production", "planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate", "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis", "PCP pathway involved in midbrain dopaminergic neuron differentiation", "PCP pathway involved in midbrain DA neurogenesis", "Wnt-activated signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate", "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production", "Wnt receptor signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation", "definition": "Any Wnt signaling pathway, planar cell polarity pathway that is involved in midbrain dopaminergic neuron differentiation. [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876]"}
{"concept_id": "C4235597", "aliases": ["canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production", "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation", "Wnt receptor signalling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate", "canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis", "canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production", "Wnt receptor signaling pathway via beta-catenin involved in midbrain DA neurogenesis", "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron production", "canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "canonical Wnt signaling pathway involved in midbrain DA neurogenesis", "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron differentiation", "canonical Wnt-mediated midbrain DA neuron differentiation", "Wnt receptor signaling pathway through beta-catenin involved in midbrain DA neurogenesis", "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron production", "Wnt receptor signaling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate", "canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate", "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation", "Wnt receptor signaling pathway through beta-catenin involved in mDA neuron differentiation", "canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wnt receptor signaling pathway via beta-catenin involved in mDA neuron differentiation", "canonical Wnt receptor signaling pathway involved in mDA neuron differentiation", "canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "Wnt receptor signalling pathway through beta-catenin involved in mDA neuron differentiation", "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron production", "canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "canonical Wnt-activated signaling pathway involved in mDA neuron differentiation", "canonical Wnt signaling pathway involved in mDA neuron differentiation", "Wnt receptor signalling pathway through beta-catenin involved in midbrain DA neurogenesis", "Wnt receptor signaling pathway via beta-catenin involved in DA neurogenesis from midbrain floor plate"], "types": ["T044"], "canonical_name": "canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "definition": "Any canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation. [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876]"}
{"concept_id": "C4235598", "aliases": ["frizzled signalling pathway involved in mDA neuron differentiation", "frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "Wg signaling pathway involved in midbrain DA neurogenesis", "Wnt receptor signalling pathway involved in mDA neuron differentiation", "Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "Wnt-mediated midbrain DA neuron differentiation", "Wg signalling pathway involved in midbrain dopaminergic neuron production", "frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate", "Wingless signalling pathway involved in mDA neuron differentiation", "Wg signalling pathway involved in mDA neuron differentiation", "Wnt signaling pathway involved in midbrain DA neurogenesis", "frizzled signalling pathway involved in midbrain DA neurogenesis", "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "Wg signalling pathway involved in midbrain DA neurogenesis", "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "Wingless signaling pathway involved in midbrain DA neurogenesis", "Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "Wingless signaling pathway involved in mDA neuron differentiation", "Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "Wg signaling pathway involved in mDA neuron differentiation", "Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "Wnt signaling pathway involved in mDA neuron differentiation", "Wingless signaling pathway involved in midbrain dopaminergic neuron production", "frizzled signalling pathway involved in midbrain dopaminergic neuron production", "Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "Wingless signalling pathway involved in midbrain dopaminergic neuron production", "frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "Wnt receptor signaling pathway involved in mDA neuron differentiation", "frizzled signaling pathway involved in midbrain dopaminergic neuron production", "frizzled signaling pathway involved in midbrain DA neurogenesis", "Wnt signaling pathway involved in midbrain dopaminergic neuron production", "Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "frizzled signaling pathway involved in mDA neuron differentiation", "Wg signaling pathway involved in midbrain dopaminergic neuron production", "Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "Wingless signalling pathway involved in midbrain DA neurogenesis"], "types": ["T044"], "canonical_name": "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "definition": "Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation. [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250, PMID:22988876, PMID:23517308]"}
{"concept_id": "C4235599", "aliases": [], "types": ["T043"], "canonical_name": "hydroxycinnamic acid transport", "definition": "The directed movement of a hydroxycinnamic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GO_REF:0000065, GOC:TermGenie, PMID:26744218]"}
{"concept_id": "C4235600", "aliases": ["upregulation of protein recruitment", "positive regulation of establishment of protein localisation", "up regulation of protein positioning", "up-regulation of protein positioning", "upregulation of establishment of protein localisation", "positive regulation of protein positioning", "positive regulation of protein recruitment", "up-regulation of establishment of protein localization", "upregulation of protein positioning", "up-regulation of protein recruitment", "upregulation of establishment of protein localization", "up regulation of establishment of protein localisation", "up-regulation of establishment of protein localisation", "up regulation of establishment of protein localization", "up regulation of protein recruitment"], "types": ["T039"], "canonical_name": "positive regulation of establishment of protein localization", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of protein localization. [GO_REF:0000058, GOC:TermGenie, PMID:22761445]"}
{"concept_id": "C4235601", "aliases": ["down-regulation of establishment of protein localization", "negative regulation of establishment of protein localisation", "downregulation of protein recruitment", "down-regulation of protein positioning", "down-regulation of establishment of protein localisation", "negative regulation of protein recruitment", "downregulation of establishment of protein localisation", "down regulation of protein positioning", "down regulation of establishment of protein localisation", "downregulation of establishment of protein localization", "down regulation of protein recruitment", "downregulation of protein positioning", "negative regulation of protein positioning", "down-regulation of protein recruitment", "down regulation of establishment of protein localization"], "types": ["T043"], "canonical_name": "negative regulation of establishment of protein localization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. [GO_REF:0000058, GOC:TermGenie, PMID:22761445]"}
{"concept_id": "C4235602", "aliases": ["DA neurogenesis from midbrain floor plate", "midbrain dopaminergic neuron production", "mDA neuron differentiation", "midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "midbrain dopaminergic neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron. [GO_REF:0000086, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17331494, PMID:19122665]"}
{"concept_id": "C4235603", "aliases": [], "types": ["T043"], "canonical_name": "folic acid import into mitochondrion"}
{"concept_id": "C4235604", "aliases": ["up-regulation of cardiac ventricle formation", "upregulation of cardiac ventricle formation", "up regulation of cardiac ventricle formation"], "types": ["T042"], "canonical_name": "positive regulation of cardiac ventricle formation", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]"}
{"concept_id": "C4235605", "aliases": ["down regulation of cardiac ventricle formation", "downregulation of cardiac ventricle formation", "down-regulation of cardiac ventricle formation"], "types": ["T039"], "canonical_name": "negative regulation of cardiac ventricle formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]"}
{"concept_id": "C4235606", "aliases": [], "types": ["T042"], "canonical_name": "regulation of cardiac ventricle formation", "definition": "Any process that modulates the frequency, rate or extent of cardiac ventricle formation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]"}
{"concept_id": "C4235607", "aliases": ["upregulation of deoxyribonucleic acid nucleotidyltransferase activity", "positive regulation of addase activity", "upregulation of terminal transferase activity", "upregulation of addase activity", "positive regulation of terminal deoxynucleotide transferase activity", "up regulation of terminal deoxynucleotidyltransferase activity", "positive regulation of terminal deoxynucleotidyltransferase activity", "upregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity", "positive regulation of terminal deoxyribonucleotidyltransferase activity", "up regulation of deoxynucleotidyl terminal transferase activity", "up regulation of terminal deoxynucleotide transferase activity", "up regulation of deoxyribonucleic acid nucleotidyltransferase activity", "upregulation of DNA nucleotidylexotransferase activity", "up regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity", "up-regulation of deoxynucleotidyl terminal transferase activity", "up regulation of terminal transferase activity", "upregulation of terminal deoxynucleotide transferase activity", "upregulation of terminal deoxynucleotidyltransferase activity", "positive regulation of deoxyribonucleic acid nucleotidyltransferase activity", "up-regulation of addase activity", "upregulation of terminal deoxyribonucleotidyltransferase activity", "up-regulation of terminal deoxyribonucleotidyltransferase activity", "up regulation of deoxyribonucleic nucleotidyltransferase activity", "up-regulation of DNA nucleotidylexotransferase activity", "up-regulation of deoxyribonucleic acid nucleotidyltransferase activity", "upregulation of deoxynucleotidyl terminal transferase activity", "up regulation of addase activity", "up-regulation of terminal deoxynucleotidyltransferase activity", "up regulation of terminal deoxyribonucleotidyltransferase activity", "positive regulation of terminal transferase activity", "positive regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity", "upregulation of deoxyribonucleic nucleotidyltransferase activity", "up-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity", "up regulation of DNA nucleotidylexotransferase activity", "up-regulation of terminal deoxynucleotide transferase activity", "up-regulation of terminal transferase activity", "up-regulation of deoxyribonucleic nucleotidyltransferase activity", "positive regulation of deoxyribonucleic nucleotidyltransferase activity", "positive regulation of deoxynucleotidyl terminal transferase activity"], "types": ["T044"], "canonical_name": "positive regulation of DNA nucleotidylexotransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of DNA nucleotidylexotransferase activity. [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]"}
{"concept_id": "C4235608", "aliases": ["downregulation of terminal deoxyribonucleotidyltransferase activity", "negative regulation of deoxyribonucleic acid nucleotidyltransferase activity", "down-regulation of DNA nucleotidylexotransferase activity", "negative regulation of terminal deoxyribonucleotidyltransferase activity", "negative regulation of deoxynucleotidyl terminal transferase activity", "downregulation of deoxynucleotidyl terminal transferase activity", "negative regulation of terminal deoxynucleotide transferase activity", "downregulation of DNA nucleotidylexotransferase activity", "down regulation of terminal deoxynucleotidyltransferase activity", "downregulation of addase activity", "down regulation of addase activity", "down regulation of deoxynucleotidyl terminal transferase activity", "down regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity", "downregulation of terminal deoxynucleotidyltransferase activity", "down regulation of terminal transferase activity", "down regulation of deoxyribonucleic nucleotidyltransferase activity", "down-regulation of addase activity", "downregulation of deoxyribonucleic acid nucleotidyltransferase activity", "downregulation of terminal transferase activity", "down regulation of DNA nucleotidylexotransferase activity", "negative regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity", "down regulation of deoxyribonucleic acid nucleotidyltransferase activity", "down-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity", "down-regulation of deoxynucleotidyl terminal transferase activity", "negative regulation of addase activity", "down-regulation of terminal deoxynucleotide transferase activity", "downregulation of terminal deoxynucleotide transferase activity", "negative regulation of deoxyribonucleic nucleotidyltransferase activity", "down regulation of terminal deoxynucleotide transferase activity", "negative regulation of terminal transferase activity", "down-regulation of terminal deoxyribonucleotidyltransferase activity", "down-regulation of deoxyribonucleic nucleotidyltransferase activity", "downregulation of deoxyribonucleic nucleotidyltransferase activity", "negative regulation of terminal deoxynucleotidyltransferase activity", "downregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity", "down-regulation of deoxyribonucleic acid nucleotidyltransferase activity", "down regulation of terminal deoxyribonucleotidyltransferase activity", "down-regulation of terminal transferase activity", "down-regulation of terminal deoxynucleotidyltransferase activity"], "types": ["T044"], "canonical_name": "negative regulation of DNA nucleotidylexotransferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA nucleotidylexotransferase activity. [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]"}
{"concept_id": "C4235609", "aliases": ["regulation of terminal deoxynucleotidyltransferase activity", "regulation of deoxyribonucleic acid nucleotidyltransferase activity", "regulation of deoxynucleotidyl terminal transferase activity", "regulation of terminal deoxynucleotide transferase activity", "regulation of terminal deoxyribonucleotidyltransferase activity", "regulation of addase activity", "regulation of deoxyribonucleic nucleotidyltransferase activity", "regulation of terminal transferase activity", "regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity"], "types": ["T044"], "canonical_name": "regulation of DNA nucleotidylexotransferase activity", "definition": "Any process that modulates the frequency, rate or extent of DNA nucleotidylexotransferase activity. [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]"}
{"concept_id": "C4235610", "aliases": ["Wnt-activated signaling pathway, planar cell polarity pathway involved in axon guidance", "Wnt-PCP signaling involved in axon guidance", "PCP pathway involved in axon pathfinding", "Wnt signaling pathway, planar cell polarity pathway involved in axon pathfinding", "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon pathfinding", "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon pathfinding", "Wnt signaling pathway, planar cell polarity pathway involved in axon guidance", "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon pathfinding", "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon guidance", "planar cell polarity pathway involved in axon pathfinding", "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon guidance", "PCP pathway involved in axon guidance"], "types": ["T044"], "canonical_name": "planar cell polarity pathway involved in axon guidance", "definition": "Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance. [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21106844, PMID:23517308]"}
{"concept_id": "C4235611", "aliases": [], "types": ["T043"], "canonical_name": "sensory neuron migration", "definition": "The orderly movement of a sensory neuron from one site to another. [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]"}
{"concept_id": "C4235612", "aliases": ["inter neuron migration", "inter-neuron migration"], "types": ["T043"], "canonical_name": "interneuron migration", "definition": "The orderly movement of an interneuron from one site to another. [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]"}
{"concept_id": "C4235613", "aliases": ["up regulation of cell proliferation in mesencephalon", "upregulation of cell proliferation in midbrain", "up regulation of cell proliferation in midbrain", "up-regulation of cell proliferation in midbrain", "up-regulation of cell proliferation in mesencephalon", "upregulation of cell proliferation in mesencephalon", "positive regulation of cell proliferation in mesencephalon"], "types": ["T043"], "canonical_name": "positive regulation of cell proliferation in midbrain", "definition": "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]"}
{"concept_id": "C4235614", "aliases": ["downregulation of cell proliferation in midbrain", "down regulation of cell proliferation in mesencephalon", "down-regulation of cell proliferation in midbrain", "downregulation of cell proliferation in mesencephalon", "negative regulation of cell proliferation in mesencephalon", "down-regulation of cell proliferation in mesencephalon", "down regulation of cell proliferation in midbrain"], "types": ["T043"], "canonical_name": "negative regulation of cell proliferation in midbrain", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]"}
{"concept_id": "C4235615", "aliases": ["regulation of cell proliferation in mesencephalon"], "types": ["T043"], "canonical_name": "regulation of cell proliferation in midbrain", "definition": "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]"}
{"concept_id": "C4235616", "aliases": ["down-regulation of cartilage condensation", "down regulation of cartilage condensation", "downregulation of cartilage condensation"], "types": ["T042"], "canonical_name": "negative regulation of cartilage condensation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cartilage condensation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17604018]"}
{"concept_id": "C4235617", "aliases": ["mini-chromosome maintenance complex binding"], "types": ["T044"], "canonical_name": "MCM complex binding", "definition": "Binding to an MCM complex. [GOC:TermGenie, PMID:12604790]"}
{"concept_id": "C4235618", "aliases": [], "types": ["T026"], "canonical_name": "amphisome membrane", "definition": "Any membrane that is part of an amphisome. [GO_REF:0000064, GOC:bhm, GOC:TermGenie, PMID:17984323]"}
{"concept_id": "C4235619", "aliases": ["Wnt/PCP co-receptor activity", "coreceptor activity involved in Wnt receptor signalling pathway, planar cell polarity pathway", "coreceptor activity involved in Wnt-activated signaling pathway, planar cell polarity pathway", "coreceptor activity involved in PCP pathway", "coreceptor activity involved in planar cell polarity pathway", "coreceptor activity involved in Wnt receptor signaling pathway, planar cell polarity pathway"], "types": ["T044"], "canonical_name": "coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway", "definition": "Any coreceptor activity that is involved in Wnt signaling pathway, planar cell polarity pathway. [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]"}
{"concept_id": "C4235620", "aliases": ["coreceptor activity involved in Wnt receptor signaling pathway through beta-catenin", "coreceptor activity involved in canonical Wnt-activated signaling pathway", "coreceptor activity involved in canonical Wnt receptor signaling pathway", "coreceptor activity involved in Wnt receptor signaling pathway via beta-catenin", "Wnt co-receptor activity, canonical signaling", "Wnt co-receptor, canonical pathway", "coreceptor activity involved in Wnt receptor signalling pathway through beta-catenin"], "types": ["T044"], "canonical_name": "coreceptor activity involved in canonical Wnt signaling pathway", "definition": "Any coreceptor activity that is involved in a canonical Wnt signaling pathway. [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]"}
{"concept_id": "C4235621", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to palmitoleic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233]"}
{"concept_id": "C4235622", "aliases": [], "types": ["T043"], "canonical_name": "response to palmitoleic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233]"}
{"concept_id": "C4235623", "aliases": ["up-regulation of mitophagy in response to mitochondrial depolarization", "up regulation of mitophagy in response to mitochondrial depolarization", "upregulation of mitophagy in response to mitochondrial depolarization"], "types": ["T043"], "canonical_name": "positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "definition": "Any process that activates or increases the frequency, rate or extent of autophagy of the mitochondrion in response to mitochondrial depolarization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]"}
{"concept_id": "C4235624", "aliases": ["downregulation of mitophagy in response to mitochondrial depolarization", "down regulation of mitophagy in response to mitochondrial depolarization", "down-regulation of mitophagy in response to mitochondrial depolarization"], "types": ["T043"], "canonical_name": "negative regulation of mitophagy in response to mitochondrial depolarization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy in response to mitochondrial depolarization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]"}
{"concept_id": "C4235625", "aliases": [], "types": ["T043"], "canonical_name": "regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "definition": "Any process that modulates the frequency, rate or extent of autophagy of mitochondrion in response to mitochondrial depolarization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]"}
{"concept_id": "C4235628", "aliases": [], "types": ["T043"], "canonical_name": "transmembrane L-cystine transport from lysosomal lumen to cytosol", "definition": "The directed movement of L-cystine from the lysosomal lumen across the lysosomal membrane and into the cytosol. [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]"}
{"concept_id": "C4235629", "aliases": [], "types": ["T043"], "canonical_name": "transmembrane L-histidine transport from lysosomal lumen to cytosol", "definition": "The directed movement of L-histidine from the lysosomal lumen across the lysosomal membrane and into the cytosol. [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]"}
{"concept_id": "C4235630", "aliases": ["transmembrane L-arginine transport from lysosomal lumen to cytosol"], "types": ["T043"], "canonical_name": "L-arginine transmembrane transport from lysosomal lumen to cytosol", "definition": "The directed movement of L-arginine across a membrane from lysosomal lumen to cytosol. [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]"}
{"concept_id": "C4235631", "aliases": [], "types": ["T043"], "canonical_name": "transmembrane L-lysine transport from lysosomal lumen to cytosol", "definition": "The directed movement of L-lysine from the lysosomal lumen across the lysosomal membrane and into the cytosol. [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]"}
{"concept_id": "C4235632", "aliases": ["upregulation of establishment of macromolecular complex localisation to telomere", "up-regulation of establishment of macromolecular complex localisation to telomere", "up regulation of establishment of macromolecular complex localization to telomere", "up-regulation of establishment of macromolecular complex localization to telomere", "up regulation of establishment of macromolecular complex localisation to telomere", "upregulation of establishment of macromolecular complex localization to telomere", "positive regulation of establishment of macromolecular complex localisation to telomere", "positive regulation of establishment of macromolecular complex localization to telomere"], "types": ["T043"], "canonical_name": "positive regulation of establishment of protein-containing complex localization to telomere", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4235634", "aliases": ["regulation of establishment of macromolecular complex localisation to telomere", "regulation of establishment of macromolecular complex localization to telomere"], "types": ["T043"], "canonical_name": "regulation of establishment of protein-containing complex localization to telomere", "definition": "Any process that modulates the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4235635", "aliases": ["positive regulation of establishment of RNA localisation to telomere", "up regulation of establishment of RNA localisation to telomere", "upregulation of establishment of RNA localisation to telomere", "up regulation of establishment of RNA localization to telomere", "up-regulation of establishment of RNA localisation to telomere", "upregulation of establishment of RNA localization to telomere", "up-regulation of establishment of RNA localization to telomere"], "types": ["T039"], "canonical_name": "positive regulation of establishment of RNA localization to telomere", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of RNA localization to telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4235636", "aliases": ["down regulation of establishment of RNA localization to telomere", "downregulation of establishment of RNA localization to telomere", "down-regulation of establishment of RNA localization to telomere", "down-regulation of establishment of RNA localisation to telomere", "negative regulation of establishment of RNA localisation to telomere", "down regulation of establishment of RNA localisation to telomere", "downregulation of establishment of RNA localisation to telomere"], "types": ["T045"], "canonical_name": "negative regulation of establishment of RNA localization to telomere", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of RNA localization to telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4235637", "aliases": ["regulation of establishment of RNA localisation to telomere"], "types": ["T045"], "canonical_name": "regulation of establishment of RNA localization to telomere", "definition": "Any process that modulates the frequency, rate or extent of establishment of RNA localization to telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4235638", "aliases": ["up regulation of maintenance of mitotic sister chromatid cohesion, telomeric", "up regulation of maintenance of sister chromatin cohesion at telomere at mitosis", "up-regulation of maintenance of sister chromatin cohesion at telomere at mitosis", "positive regulation of maintenance of sister chromatin cohesion at telomere at mitosis", "upregulation of maintenance of telomeric mitotic sister chromatin cohesion", "positive regulation of maintenance of mitotic sister chromatin cohesion at telomere", "upregulation of maintenance of mitotic sister chromatid cohesion, telomeric", "up regulation of maintenance of mitotic sister chromatin cohesion at telomere", "upregulation of maintenance of mitotic sister chromatin cohesion at telomere", "up-regulation of maintenance of mitotic sister chromatid cohesion, telomeric", "positive regulation of maintenance of telomeric mitotic sister chromatin cohesion", "upregulation of maintenance of sister chromatin cohesion at telomere at mitosis", "up regulation of maintenance of telomeric mitotic sister chromatin cohesion", "up-regulation of maintenance of telomeric mitotic sister chromatin cohesion", "up-regulation of maintenance of mitotic sister chromatin cohesion at telomere"], "types": ["T043"], "canonical_name": "positive regulation of maintenance of mitotic sister chromatid cohesion, telomeric", "definition": "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]"}
{"concept_id": "C4235639", "aliases": ["down-regulation of maintenance of telomeric mitotic sister chromatin cohesion", "downregulation of maintenance of telomeric mitotic sister chromatin cohesion", "down-regulation of maintenance of mitotic sister chromatid cohesion, telomeric", "down regulation of maintenance of telomeric mitotic sister chromatin cohesion", "down-regulation of maintenance of mitotic sister chromatin cohesion at telomere", "downregulation of maintenance of mitotic sister chromatid cohesion, telomeric", "down-regulation of maintenance of sister chromatin cohesion at telomere at mitosis", "downregulation of maintenance of mitotic sister chromatin cohesion at telomere", "negative regulation of maintenance of mitotic sister chromatin cohesion at telomere", "downregulation of maintenance of sister chromatin cohesion at telomere at mitosis", "down regulation of maintenance of mitotic sister chromatid cohesion, telomeric", "down regulation of maintenance of sister chromatin cohesion at telomere at mitosis", "negative regulation of maintenance of telomeric mitotic sister chromatin cohesion", "negative regulation of maintenance of sister chromatin cohesion at telomere at mitosis", "down regulation of maintenance of mitotic sister chromatin cohesion at telomere"], "types": ["T043"], "canonical_name": "negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]"}
{"concept_id": "C4235640", "aliases": ["regulation of maintenance of telomeric mitotic sister chromatin cohesion", "regulation of maintenance of mitotic sister chromatin cohesion at telomere", "regulation of maintenance of sister chromatin cohesion at telomere at mitosis"], "types": ["T043"], "canonical_name": "regulation of maintenance of mitotic sister chromatid cohesion, telomeric", "definition": "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]"}
{"concept_id": "C4235641", "aliases": ["up-regulation of endothelial cell-matrix adhesion via fibronectin", "upregulation of endothelial cell-matrix adhesion via fibronectin", "up regulation of endothelial cell-matrix adhesion via fibronectin"], "types": ["T044"], "canonical_name": "positive regulation of endothelial cell-matrix adhesion via fibronectin", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962]"}
{"concept_id": "C4235642", "aliases": ["down-regulation of endothelial cell-matrix adhesion via fibronectin", "downregulation of endothelial cell-matrix adhesion via fibronectin", "down regulation of endothelial cell-matrix adhesion via fibronectin"], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell-matrix adhesion via fibronectin", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962]"}
{"concept_id": "C4235643", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelial cell-matrix adhesion via fibronectin", "definition": "Any process that modulates the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962]"}
{"concept_id": "C4235644", "aliases": [], "types": ["T044"], "canonical_name": "ESCRT III complex disassembly", "definition": "The disaggregation of an ESCRT III complex into its constituent components. [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296]"}
{"concept_id": "C4235645", "aliases": ["ESCRT III complex formation"], "types": ["T044"], "canonical_name": "ESCRT III complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an ESCRT III complex. [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296]"}
{"concept_id": "C4235646", "aliases": ["upregulation of myosin II filament organization", "up-regulation of myosin II filament organization", "up regulation of myosin II filament organization", "upregulation of myosin II filament organisation", "positive regulation of myosin II filament organisation", "up regulation of myosin II filament organisation", "up-regulation of myosin II filament organisation"], "types": ["T043"], "canonical_name": "positive regulation of myosin II filament organization", "definition": "Any process that activates or increases the frequency, rate or extent of myosin II filament organization. [GO_REF:0000058, GOC:TermGenie, PMID:22761445]"}
{"concept_id": "C4235647", "aliases": ["down regulation of myosin II filament organization", "down-regulation of myosin II filament organization", "downregulation of myosin II filament organisation", "down regulation of myosin II filament organisation", "negative regulation of myosin II filament organisation", "down-regulation of myosin II filament organisation", "downregulation of myosin II filament organization"], "types": ["T043"], "canonical_name": "negative regulation of myosin II filament organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament organization. [GO_REF:0000058, GOC:TermGenie, PMID:22761445]"}
{"concept_id": "C4235648", "aliases": ["upregulation of Ito cell proliferation", "positive regulation of perisinusoidal cell proliferation", "up regulation of hepatic stellate cell proliferation", "up-regulation of perisinusoidal cell proliferation", "up regulation of Ito cell proliferation", "up-regulation of Ito cell proliferation", "up-regulation of hepatic stellate cell proliferation", "upregulation of hepatic stellate cell proliferation", "up regulation of perisinusoidal cell proliferation", "upregulation of perisinusoidal cell proliferation", "positive regulation of Ito cell proliferation", "up-regulation of hepatic perisinusoidal cell proliferation", "positive regulation of hepatic perisinusoidal cell proliferation", "upregulation of hepatic perisinusoidal cell proliferation", "up regulation of hepatic perisinusoidal cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of hepatic stellate cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:15358192]"}
{"concept_id": "C4235649", "aliases": ["downregulation of hepatic perisinusoidal cell proliferation", "downregulation of hepatic stellate cell proliferation", "down regulation of Ito cell proliferation", "down regulation of perisinusoidal cell proliferation", "down-regulation of perisinusoidal cell proliferation", "down-regulation of hepatic perisinusoidal cell proliferation", "negative regulation of Ito cell proliferation", "negative regulation of hepatic perisinusoidal cell proliferation", "downregulation of Ito cell proliferation", "down regulation of hepatic perisinusoidal cell proliferation", "down-regulation of Ito cell proliferation", "down-regulation of hepatic stellate cell proliferation", "down regulation of hepatic stellate cell proliferation", "downregulation of perisinusoidal cell proliferation", "negative regulation of perisinusoidal cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of hepatic stellate cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:15358192]"}
{"concept_id": "C4235650", "aliases": ["regulation of Ito cell proliferation", "regulation of hepatic perisinusoidal cell proliferation", "regulation of perisinusoidal cell proliferation"], "types": ["T043"], "canonical_name": "regulation of hepatic stellate cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of hepatic stellate cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:15358192]"}
{"concept_id": "C4235651", "aliases": ["endosomal sorting complex required for transport disassembly"], "types": ["T044"], "canonical_name": "ESCRT complex disassembly", "definition": "The disaggregation of an ESCRT complex into its constituent components. [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109]"}
{"concept_id": "C4235652", "aliases": ["ESCRT complex formation", "endosomal sorting complex required for transport assembly", "endosomal sorting complex required for transport formation"], "types": ["T044"], "canonical_name": "ESCRT complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an ESCRT complex. [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109]"}
{"concept_id": "C4235653", "aliases": ["up regulation of STAT cascade", "up-regulation of STAT cascade", "upregulation of STAT signalling pathway", "up regulation of kinase-STAT cascade", "up regulation of STAT signalling pathway", "up-regulation of kinase activated-STAT cascade", "up-regulation of STAT signalling pathway", "positive regulation of kinase-STAT cascade", "upregulation of kinase-STAT cascade", "up-regulation of kinase-STAT cascade", "upregulation of kinase activated-STAT cascade", "upregulation of STAT cascade", "positive regulation of kinase activated-STAT cascade", "positive regulation of STAT signalling pathway", "up regulation of kinase activated-STAT cascade"], "types": ["T044"], "canonical_name": "positive regulation of receptor signaling pathway via STAT", "definition": "Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT. [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]"}
{"concept_id": "C4235654", "aliases": ["downregulation of STAT cascade", "negative regulation of kinase-STAT cascade", "negative regulation of kinase activated-STAT cascade", "downregulation of kinase-STAT cascade", "downregulation of STAT signalling pathway", "down regulation of kinase-STAT cascade", "down-regulation of kinase-STAT cascade", "negative regulation of STAT signalling pathway", "downregulation of kinase activated-STAT cascade", "down regulation of kinase activated-STAT cascade", "down regulation of STAT cascade", "down-regulation of kinase activated-STAT cascade", "down-regulation of STAT signalling pathway", "down regulation of STAT signalling pathway", "down-regulation of STAT cascade"], "types": ["T044"], "canonical_name": "negative regulation of receptor signaling pathway via STAT", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of receptor signaling via STAT. [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]"}
{"concept_id": "C4235655", "aliases": ["regulation of STAT signalling pathway", "regulation of kinase activated-STAT cascade", "regulation of kinase-STAT cascade"], "types": ["T044"], "canonical_name": "regulation of receptor signaling pathway via STAT", "definition": "Any process that modulates the frequency, rate or extent of receptor signaling via STAT. [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]"}
{"concept_id": "C4235656", "aliases": ["upregulation of excitatory synapse assembly", "upregulation of excitatory synapse formation", "up-regulation of excitatory synapse formation", "positive regulation of excitatory synapse formation", "up-regulation of excitatory synapse assembly", "up regulation of excitatory synapse assembly", "up regulation of excitatory synapse formation"], "types": ["T042"], "canonical_name": "positive regulation of excitatory synapse assembly", "definition": "Any process that activates or increases the frequency, rate or extent of excitatory synapse assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302]"}
{"concept_id": "C4235657", "aliases": ["downregulation of excitatory synapse formation", "down-regulation of excitatory synapse assembly", "down regulation of excitatory synapse assembly", "down regulation of excitatory synapse formation", "downregulation of excitatory synapse assembly", "negative regulation of excitatory synapse formation", "down-regulation of excitatory synapse formation"], "types": ["T042"], "canonical_name": "negative regulation of excitatory synapse assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235658", "aliases": ["regulation of excitatory synapse formation"], "types": ["T042"], "canonical_name": "regulation of excitatory synapse assembly", "definition": "Any process that modulates the frequency, rate or extent of excitatory synapse assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235659", "aliases": [], "types": ["T042"], "canonical_name": "cranial skeletal system development", "definition": "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227]"}
{"concept_id": "C4235660", "aliases": ["LRP5/6 signalosome assembly", "Wnt signalosome complex assembly", "LRP5/6 signalosome formation", "Wnt-LRP5/6 signalosome formation", "Wnt signalosome formation", "Wnt signalosome complex formation", "Wnt-LRP5/6 signalosome assembly"], "types": ["T044"], "canonical_name": "Wnt signalosome assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a Wnt signalosome. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650]"}
{"concept_id": "C4235661", "aliases": ["APC-Axin-1-beta-catenin complex disassembly", "Axin-APC-beta-catenin-GSK3B complex disassembly", "BDC disassembly", "dissociation of beta-catenin degradation complex", "beta-catenin degradation complex disassembly"], "types": ["T044"], "canonical_name": "beta-catenin destruction complex disassembly", "definition": "The disaggregation of a beta-catenin destruction complex into its constituent components. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23169527]"}
{"concept_id": "C4235662", "aliases": ["beta-catenin degradation complex formation", "beta-catenin destruction complex formation", "beta-catenin degradation complex assembly", "APC-Axin-1-beta-catenin complex formation", "APC-Axin-1-beta-catenin complex assembly", "BDC assembly", "BDC formation", "Axin-APC-beta-catenin-GSK3B complex formation", "Axin-APC-beta-catenin-GSK3B complex assembly"], "types": ["T044"], "canonical_name": "beta-catenin destruction complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin destruction complex. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17143292, PMID:23169527]"}
{"concept_id": "C4235663", "aliases": ["upregulation of telomerase catalytic core complex assembly", "up regulation of telomerase catalytic core complex assembly", "positive regulation of telomerase catalytic core complex formation", "up regulation of telomerase catalytic core complex formation", "up-regulation of telomerase catalytic core complex assembly", "upregulation of telomerase catalytic core complex formation", "up-regulation of telomerase catalytic core complex formation"], "types": ["T043"], "canonical_name": "positive regulation of telomerase catalytic core complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4235664", "aliases": ["downregulation of telomerase catalytic core complex assembly", "down regulation of telomerase catalytic core complex assembly", "downregulation of telomerase catalytic core complex formation", "negative regulation of telomerase catalytic core complex formation", "down regulation of telomerase catalytic core complex formation", "down-regulation of telomerase catalytic core complex assembly", "down-regulation of telomerase catalytic core complex formation"], "types": ["T043"], "canonical_name": "negative regulation of telomerase catalytic core complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase catalytic core complex assembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4235665", "aliases": ["regulation of telomerase catalytic core complex formation"], "types": ["T043"], "canonical_name": "regulation of telomerase catalytic core complex assembly", "definition": "Any process that modulates the frequency, rate or extent of telomerase catalytic core complex assembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4235666", "aliases": ["cellular response to sulfane", "cellular response to dihydridosulfur"], "types": ["T043"], "canonical_name": "cellular response to hydrogen sulfide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24012591]"}
{"concept_id": "C4235667", "aliases": ["response to dihydridosulfur", "response to sulfane"], "types": ["T043"], "canonical_name": "response to hydrogen sulfide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24012591]"}
{"concept_id": "C4235668", "aliases": ["up regulation of generation of L-type calcium current", "upregulation of generation of L-type calcium current", "up-regulation of generation of L-type calcium current"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "definition": "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel. [GO_REF:0000058, GOC:TermGenie, PMID:23071515]"}
{"concept_id": "C4235669", "aliases": ["down-regulation of generation of L-type calcium current", "downregulation of generation of L-type calcium current", "down regulation of generation of L-type calcium current"], "types": ["T043"], "canonical_name": "negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel. [GO_REF:0000058, GOC:TermGenie, PMID:23071515]"}
{"concept_id": "C4235670", "aliases": ["up regulation of DNA ligase activity", "upregulation of DNA ligase activity", "up-regulation of DNA ligase activity"], "types": ["T045"], "canonical_name": "positive regulation of DNA ligase activity", "definition": "Any process that activates or increases the frequency, rate or extent of DNA ligase activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648]"}
{"concept_id": "C4235671", "aliases": ["downregulation of DNA ligase activity", "down-regulation of DNA ligase activity", "down regulation of DNA ligase activity"], "types": ["T045"], "canonical_name": "negative regulation of DNA ligase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligase activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648]"}
{"concept_id": "C4235672", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA ligase activity", "definition": "Any process that modulates the frequency, rate or extent of DNA ligase activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648]"}
{"concept_id": "C4235673", "aliases": ["upregulation of telomerase RNA localization to Cajal body", "up regulation of telomerase RNA localization to Cajal body", "up-regulation of telomerase RNA localization to Cajal body"], "types": ["T043"], "canonical_name": "positive regulation of telomerase RNA localization to Cajal body", "definition": "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]"}
{"concept_id": "C4235674", "aliases": ["down regulation of telomerase RNA localization to Cajal body", "down-regulation of telomerase RNA localization to Cajal body", "downregulation of telomerase RNA localization to Cajal body"], "types": ["T043"], "canonical_name": "negative regulation of telomerase RNA localization to Cajal body", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA localization to Cajal body. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]"}
{"concept_id": "C4235675", "aliases": [], "types": ["T043"], "canonical_name": "regulation of telomerase RNA localization to Cajal body", "definition": "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]"}
{"concept_id": "C4235676", "aliases": ["positive regulation of protein localisation in Cajal body", "up-regulation of protein localization to Cajal body", "up-regulation of protein localisation to Cajal body", "up regulation of protein localisation in Cajal body", "upregulation of protein localization in Cajal body", "upregulation of protein localization to Cajal body", "up regulation of protein localization in Cajal body", "positive regulation of protein localization in Cajal body", "up-regulation of protein localisation in Cajal body", "upregulation of protein localisation in Cajal body", "up-regulation of protein localization in Cajal body", "up regulation of protein localization to Cajal body", "up regulation of protein localisation to Cajal body", "upregulation of protein localisation to Cajal body", "positive regulation of protein localisation to Cajal body"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to Cajal body", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]"}
{"concept_id": "C4235677", "aliases": ["down regulation of protein localization to Cajal body", "down-regulation of protein localisation to Cajal body", "down regulation of protein localization in Cajal body", "down-regulation of protein localization to Cajal body", "down-regulation of protein localisation in Cajal body", "negative regulation of protein localisation in Cajal body", "downregulation of protein localization to Cajal body", "down regulation of protein localisation in Cajal body", "down-regulation of protein localization in Cajal body", "downregulation of protein localisation to Cajal body", "negative regulation of protein localisation to Cajal body", "downregulation of protein localisation in Cajal body", "down regulation of protein localisation to Cajal body", "negative regulation of protein localization in Cajal body", "downregulation of protein localization in Cajal body"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to Cajal body", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to Cajal body. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]"}
{"concept_id": "C4235678", "aliases": ["regulation of protein localisation to Cajal body", "regulation of protein localisation in Cajal body", "regulation of protein localization in Cajal body"], "types": ["T043"], "canonical_name": "regulation of protein localization to Cajal body", "definition": "Any process that modulates the frequency, rate or extent of protein localization to Cajal body. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]"}
{"concept_id": "C4235679", "aliases": ["protein localization in Cajal body", "protein localisation in Cajal body", "protein localisation to Cajal body"], "types": ["T043"], "canonical_name": "protein localization to Cajal body", "definition": "A process in which a protein is transported to, or maintained in, a location within a Cajal body. [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]"}
{"concept_id": "C4235680", "aliases": ["up-regulation of beta-catenin-TCF complex assembly", "positive regulation of beta-catenin-TCF complex formation", "up-regulation of beta-catenin-TCF complex formation", "upregulation of beta-catenin-TCF complex formation", "upregulation of beta-catenin-TCF complex assembly", "up regulation of beta-catenin-TCF complex formation", "up regulation of beta-catenin-TCF complex assembly"], "types": ["T043"], "canonical_name": "positive regulation of beta-catenin-TCF complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of beta-catenin-TCF complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235681", "aliases": ["down-regulation of beta-catenin-TCF complex assembly", "down regulation of beta-catenin-TCF complex assembly", "down regulation of beta-catenin-TCF complex formation", "negative regulation of beta-catenin-TCF complex formation", "downregulation of beta-catenin-TCF complex formation", "downregulation of beta-catenin-TCF complex assembly", "down-regulation of beta-catenin-TCF complex formation"], "types": ["T043"], "canonical_name": "negative regulation of beta-catenin-TCF complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of beta-catenin-TCF complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]"}
{"concept_id": "C4235682", "aliases": ["regulation of beta-catenin-TCF complex formation"], "types": ["T043"], "canonical_name": "regulation of beta-catenin-TCF complex assembly", "definition": "Any process that modulates the frequency, rate or extent of beta-catenin-TCF complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235683", "aliases": ["inhibitory synapse formation"], "types": ["T043"], "canonical_name": "inhibitory synapse assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235684", "aliases": ["excitatory synapse formation"], "types": ["T042"], "canonical_name": "excitatory synapse assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302]"}
{"concept_id": "C4235685", "aliases": ["DNA synthesis involved in mitotic nuclear cell cycle DNA replication", "DNA anabolism involved in mitotic nuclear cell cycle DNA replication", "DNA synthesis involved in mitotic cell cycle DNA replication", "DNA synthesis involved in DNA replication involved in S phase involved in mitotic cell cycle", "DNA biosynthetic process involved in DNA replication involved in S-phase involved in mitotic cell cycle", "DNA biosynthesis involved in mitotic DNA replication", "DNA anabolism involved in DNA replication involved in S-phase involved in mitotic cell cycle", "DNA biosynthetic process involved in mitotic cell cycle DNA replication", "DNA formation involved in DNA replication involved in S phase involved in mitotic cell cycle", "DNA biosynthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle", "DNA formation involved in DNA replication involved in S-phase involved in mitotic cell cycle", "DNA biosynthesis involved in DNA replication involved in S phase involved in mitotic cell cycle", "DNA biosynthetic process involved in mitotic DNA replication", "DNA anabolism involved in DNA replication involved in S phase involved in mitotic cell cycle", "DNA formation involved in mitotic DNA replication", "DNA anabolism involved in mitotic cell cycle DNA replication", "DNA biosynthetic process involved in mitotic nuclear cell cycle DNA replication", "DNA biosynthesis involved in mitotic nuclear cell cycle DNA replication", "DNA synthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle", "DNA anabolism involved in mitotic DNA replication", "DNA biosynthesis involved in mitotic cell cycle DNA replication", "DNA formation involved in mitotic nuclear cell cycle DNA replication", "DNA formation involved in mitotic cell cycle DNA replication", "DNA biosynthetic process involved in DNA replication involved in S phase involved in mitotic cell cycle"], "types": ["T044"], "canonical_name": "DNA synthesis involved in mitotic DNA replication", "definition": "Any DNA biosynthetic process that is involved in mitotic DNA replication. [GO_REF:0000060, GOC:TermGenie, PMID:16849602]"}
{"concept_id": "C4235686", "aliases": ["up regulation of endothelial cell chemotaxis to vascular endothelial growth factor", "up-regulation of endothelial cell chemotaxis to vascular endothelial growth factor", "upregulation of endothelial cell chemotaxis to vascular endothelial growth factor"], "types": ["T043"], "canonical_name": "positive regulation of endothelial cell chemotaxis to vascular endothelial growth factor", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851]"}
{"concept_id": "C4235687", "aliases": ["down-regulation of endothelial cell chemotaxis to vascular endothelial growth factor", "down regulation of endothelial cell chemotaxis to vascular endothelial growth factor", "downregulation of endothelial cell chemotaxis to vascular endothelial growth factor"], "types": ["T043"], "canonical_name": "negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851]"}
{"concept_id": "C4235688", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelial cell chemotaxis to vascular endothelial growth factor", "definition": "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851]"}
{"concept_id": "C4235689", "aliases": ["cytoplasmic membrane-enclosed vesicle lumen of cytolytic granule", "cytoplasmic membrane-bounded vesicle lumen of cytolytic granule", "cytolytic granule cytoplasmic membrane-bounded vesicle lumen"], "types": ["T026"], "canonical_name": "cytolytic granule lumen", "definition": "Any cytoplasmic membrane-bounded vesicle lumen that is part of a cytolytic granule. [GO_REF:0000064, GOC:TermGenie, PMID:17272266, PMID:21247065]"}
{"concept_id": "C4235690", "aliases": ["PA700-dependent proteasome activator binding"], "types": ["T044"], "canonical_name": "proteasome regulatory particle binding", "definition": "Binding to a proteasome regulatory particle. [GOC:TermGenie, PMID:16096059]"}
{"concept_id": "C4235691", "aliases": ["macropain binding"], "types": ["T044"], "canonical_name": "proteasome core complex binding", "definition": "Binding to a proteasome core complex. [GOC:TermGenie, PMID:16096059]"}
{"concept_id": "C4235692", "aliases": ["protein localisation in ascospore wall", "protein localization in ascospore wall", "protein localisation to ascospore wall"], "types": ["T043"], "canonical_name": "protein localization to ascospore wall", "definition": "A process in which a protein is transported to, or maintained in, a location within an ascospore wall. [GO_REF:0000087, GOC:TermGenie, PMID:24623719]"}
{"concept_id": "C4235693", "aliases": ["up regulation of establishment of protein localisation to telomere", "upregulation of establishment of protein localization to telomere", "up regulation of establishment of protein localization to telomere", "up-regulation of establishment of protein localisation to telomere", "positive regulation of establishment of protein localization to chromosome, telomeric region", "up-regulation of establishment of protein localization to chromosome, telomeric region", "up regulation of establishment of protein localization to chromosome, telomeric region", "positive regulation of establishment of protein localisation to telomere", "up-regulation of establishment of protein localization to telomere", "upregulation of establishment of protein localization to chromosome, telomeric region", "upregulation of establishment of protein localisation to telomere"], "types": ["T043"], "canonical_name": "positive regulation of establishment of protein localization to telomere", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]"}
{"concept_id": "C4235694", "aliases": ["downregulation of establishment of protein localization to chromosome, telomeric region", "downregulation of establishment of protein localization to telomere", "down regulation of establishment of protein localisation to telomere", "down-regulation of establishment of protein localization to chromosome, telomeric region", "down-regulation of establishment of protein localization to telomere", "negative regulation of establishment of protein localisation to telomere", "downregulation of establishment of protein localisation to telomere", "negative regulation of establishment of protein localization to chromosome, telomeric region", "down regulation of establishment of protein localization to telomere", "down regulation of establishment of protein localization to chromosome, telomeric region", "down-regulation of establishment of protein localisation to telomere"], "types": ["T043"], "canonical_name": "negative regulation of establishment of protein localization to telomere", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]"}
{"concept_id": "C4235695", "aliases": ["up regulation of cell chemotaxis to fibroblast growth factor", "up-regulation of cell chemotaxis to fibroblast growth factor", "upregulation of cell chemotaxis to fibroblast growth factor"], "types": ["T043"], "canonical_name": "positive regulation of cell chemotaxis to fibroblast growth factor", "definition": "Any process that activates or increases the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]"}
{"concept_id": "C4235696", "aliases": ["downregulation of cell chemotaxis to fibroblast growth factor", "down-regulation of cell chemotaxis to fibroblast growth factor", "down regulation of cell chemotaxis to fibroblast growth factor"], "types": ["T043"], "canonical_name": "negative regulation of cell chemotaxis to fibroblast growth factor", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]"}
{"concept_id": "C4235697", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell chemotaxis to fibroblast growth factor", "definition": "Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]"}
{"concept_id": "C4235698", "aliases": ["down regulation of establishment of bipolar cell polarity", "downregulation of establishment of bipolar cell polarity", "down-regulation of establishment of bipolar cell polarity"], "types": ["T043"], "canonical_name": "negative regulation of establishment of bipolar cell polarity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of bipolar cell polarity. [GO_REF:0000058, GOC:TermGenie, PMID:26525038]"}
{"concept_id": "C4235699", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to L-glutamine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23185570]"}
{"concept_id": "C4235700", "aliases": [], "types": ["T043"], "canonical_name": "response to L-glutamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23185570]"}
{"concept_id": "C4235701", "aliases": ["cellular response to trinitroglycerin", "cellular response to nitroglycerine", "cellular response to trinitroglycerol", "cellular response to nitroglycerol"], "types": ["T043"], "canonical_name": "cellular response to nitroglycerin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25626975]"}
{"concept_id": "C4235702", "aliases": ["response to nitroglycerol", "response to trinitroglycerin", "response to trinitroglycerol", "response to nitroglycerine"], "types": ["T043"], "canonical_name": "response to nitroglycerin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25626975]"}
{"concept_id": "C4235703", "aliases": ["TOR complex 2 binding", "TORC 2 complex binding", "TORC2 binding", "rapamycin and nutrient-insensitive TOR complex binding"], "types": ["T044"], "canonical_name": "TORC2 complex binding", "definition": "Binding to a TORC2 complex. [GOC:TermGenie, PMID:20660630]"}
{"concept_id": "C4235704", "aliases": ["up-regulation of male germ-line stem cell asymmetric division", "up regulation of male germ-line stem cell asymmetric division", "upregulation of male germ-line stem cell asymmetric division", "up-regulation of male germ-line stem cell renewal", "up regulation of male germ-line stem cell renewal", "upregulation of male germ-line stem cell renewal", "positive regulation of male germ-line stem cell renewal"], "types": ["T043"], "canonical_name": "positive regulation of male germ-line stem cell asymmetric division", "definition": "Any process that activates or increases the frequency, rate or extent of male germ-line stem cell asymmetric division. [GO_REF:0000058, GOC:TermGenie, PMID:19339709]"}
{"concept_id": "C4235705", "aliases": ["down-regulation of male germ-line stem cell renewal", "down regulation of male germ-line stem cell renewal", "downregulation of male germ-line stem cell asymmetric division", "downregulation of male germ-line stem cell renewal", "down regulation of male germ-line stem cell asymmetric division", "negative regulation of male germ-line stem cell renewal", "down-regulation of male germ-line stem cell asymmetric division"], "types": ["T043"], "canonical_name": "negative regulation of male germ-line stem cell asymmetric division", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of male germ-line stem cell asymmetric division. [GO_REF:0000058, GOC:TermGenie, PMID:19339709]"}
{"concept_id": "C4235706", "aliases": ["regulation of male germ-line stem cell renewal"], "types": ["T043"], "canonical_name": "regulation of male germ-line stem cell asymmetric division", "definition": "Any process that modulates the frequency, rate or extent of male germ-line stem cell asymmetric division. [GO_REF:0000058, GOC:TermGenie, PMID:19339709]"}
{"concept_id": "C4235707", "aliases": ["beta-catenin-TCF complex formation"], "types": ["T044"], "canonical_name": "beta-catenin-TCF complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]"}
{"concept_id": "C4235708", "aliases": ["facio-acoustic ganglion morphogenesis", "acousticofacial ganglion morphogenesis"], "types": ["T043"], "canonical_name": "facioacoustic ganglion morphogenesis", "definition": "The developmental process by which an acoustico-facial VII-VIII ganglion complex is generated and organized. [GO_REF:0000083, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247]"}
{"concept_id": "C4235710", "aliases": ["upregulation of removal of oxygen free radicals", "upregulation of removal of superoxide radicals", "positive regulation of cellular detoxification of superoxide radicals", "up-regulation of removal of superoxide radicals", "up-regulation of removal of O2-", "up regulation of removal of oxygen free radicals", "up regulation of removal of O2-", "up-regulation of removal of oxygen free radicals", "up regulation of removal of superoxide radicals", "positive regulation of removal of oxygen free radicals", "up-regulation of cellular detoxification of superoxide radicals", "positive regulation of removal of O2-", "upregulation of cellular detoxification of superoxide radicals", "upregulation of removal of O2-", "up regulation of cellular detoxification of superoxide radicals"], "types": ["T043"], "canonical_name": "positive regulation of removal of superoxide radicals", "definition": "Any process that activates or increases the frequency, rate or extent of removal of superoxide radicals. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756]"}
{"concept_id": "C4235711", "aliases": ["down regulation of cellular detoxification of superoxide radicals", "down regulation of removal of superoxide radicals", "down-regulation of removal of superoxide radicals", "negative regulation of removal of oxygen free radicals", "downregulation of removal of superoxide radicals", "down-regulation of cellular detoxification of superoxide radicals", "downregulation of cellular detoxification of superoxide radicals", "negative regulation of cellular detoxification of superoxide radicals", "down regulation of removal of oxygen free radicals", "downregulation of removal of O2-", "negative regulation of removal of O2-", "down-regulation of removal of oxygen free radicals", "down regulation of removal of O2-", "downregulation of removal of oxygen free radicals", "down-regulation of removal of O2-"], "types": ["T043"], "canonical_name": "negative regulation of removal of superoxide radicals", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of removal of superoxide radicals. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756]"}
{"concept_id": "C4235712", "aliases": ["up-regulation of aortic smooth muscle cell differentiation", "upregulation of aortic smooth muscle cell differentiation", "up regulation of aortic smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of aortic smooth muscle cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]"}
{"concept_id": "C4235713", "aliases": ["down-regulation of aortic smooth muscle cell differentiation", "downregulation of aortic smooth muscle cell differentiation", "down regulation of aortic smooth muscle cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of aortic smooth muscle cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]"}
{"concept_id": "C4235714", "aliases": [], "types": ["T043"], "canonical_name": "regulation of aortic smooth muscle cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]"}
{"concept_id": "C4235715", "aliases": ["upregulation of hydrogen sulfide anabolism", "up regulation of hydrogen sulphide biosynthetic process", "up regulation of hydrogen sulfide biosynthetic process", "up-regulation of hydrogen sulfide formation", "positive regulation of hydrogen sulfide anabolism", "positive regulation of hydrogen sulfide biosynthesis", "up-regulation of hydrogen sulfide anabolism", "up-regulation of hydrogen sulphide biosynthesis", "positive regulation of hydrogen sulfide formation", "up regulation of hydrogen sulfide biosynthesis", "up regulation of hydrogen sulphide biosynthesis", "up regulation of hydrogen sulfide formation", "upregulation of hydrogen sulfide synthesis", "up regulation of hydrogen sulfide anabolism", "up-regulation of hydrogen sulphide biosynthetic process", "upregulation of hydrogen sulfide biosynthetic process", "up-regulation of hydrogen sulfide synthesis", "positive regulation of hydrogen sulphide biosynthesis", "upregulation of hydrogen sulfide formation", "up regulation of hydrogen sulfide synthesis", "upregulation of hydrogen sulphide biosynthesis", "upregulation of hydrogen sulphide biosynthetic process", "up-regulation of hydrogen sulfide biosynthesis", "up-regulation of hydrogen sulfide biosynthetic process", "upregulation of hydrogen sulfide biosynthesis", "positive regulation of hydrogen sulfide synthesis", "positive regulation of hydrogen sulphide biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of hydrogen sulfide biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of hydrogen sulfide biosynthetic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]"}
{"concept_id": "C4235716", "aliases": ["down-regulation of hydrogen sulfide formation", "down-regulation of hydrogen sulfide anabolism", "negative regulation of hydrogen sulfide formation", "negative regulation of hydrogen sulphide biosynthesis", "negative regulation of hydrogen sulfide anabolism", "downregulation of hydrogen sulfide biosynthetic process", "downregulation of hydrogen sulfide biosynthesis", "down-regulation of hydrogen sulfide synthesis", "downregulation of hydrogen sulfide anabolism", "down regulation of hydrogen sulfide biosynthetic process", "down regulation of hydrogen sulfide biosynthesis", "down regulation of hydrogen sulfide formation", "down regulation of hydrogen sulfide anabolism", "downregulation of hydrogen sulphide biosynthesis", "down regulation of hydrogen sulphide biosynthesis", "down-regulation of hydrogen sulphide biosynthesis", "down regulation of hydrogen sulfide synthesis", "downregulation of hydrogen sulfide synthesis", "downregulation of hydrogen sulphide biosynthetic process", "negative regulation of hydrogen sulfide synthesis", "negative regulation of hydrogen sulfide biosynthesis", "down-regulation of hydrogen sulphide biosynthetic process", "down regulation of hydrogen sulphide biosynthetic process", "negative regulation of hydrogen sulphide biosynthetic process", "down-regulation of hydrogen sulfide biosynthetic process", "down-regulation of hydrogen sulfide biosynthesis", "downregulation of hydrogen sulfide formation"], "types": ["T044"], "canonical_name": "negative regulation of hydrogen sulfide biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen sulfide biosynthetic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]"}
{"concept_id": "C4235717", "aliases": ["regulation of hydrogen sulfide anabolism", "regulation of hydrogen sulfide biosynthesis", "regulation of hydrogen sulphide biosynthetic process", "regulation of hydrogen sulfide formation", "regulation of hydrogen sulfide synthesis", "regulation of hydrogen sulphide biosynthesis"], "types": ["T044"], "canonical_name": "regulation of hydrogen sulfide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of hydrogen sulfide biosynthetic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]"}
{"concept_id": "C4235718", "aliases": [], "types": ["T044"], "canonical_name": "purine nucleobase transmembrane transport", "definition": "The process in which a purine nucleobase is transported across a membrane. [GO_REF:0000069, GOC:TermGenie]"}
{"concept_id": "C4235720", "aliases": [], "types": ["T043"], "canonical_name": "chloroplast disassembly", "definition": "The disaggregation of a chloroplast into its constituent components. [GO_REF:0000079, GOC:TermGenie, PMID:26494759]"}
{"concept_id": "C4235721", "aliases": ["peritoneal cavity lining development"], "types": ["T042"], "canonical_name": "parietal peritoneum development", "definition": "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]"}
{"concept_id": "C4235722", "aliases": [], "types": ["T042"], "canonical_name": "visceral peritoneum development", "definition": "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]"}
{"concept_id": "C4235723", "aliases": ["tunica serosa development", "wall of serous sac development"], "types": ["T042"], "canonical_name": "serous membrane development", "definition": "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure. [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]"}
{"concept_id": "C4235724", "aliases": ["up-regulation of protein localization to telomere", "up-regulation of protein localization to chromosome, telomeric region", "up regulation of protein localisation to chromosome, telomeric region", "upregulation of protein localization to chromosome, telomeric region", "up-regulation of protein localisation to chromosome, telomeric region", "upregulation of protein localization to telomere", "up regulation of protein localization to chromosome, telomeric region", "upregulation of protein localisation to chromosome, telomeric region", "positive regulation of protein localisation to chromosome, telomeric region", "positive regulation of protein localization to telomere", "up regulation of protein localization to telomere"], "types": ["T045"], "canonical_name": "positive regulation of protein localization to chromosome, telomeric region", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455]"}
{"concept_id": "C4235725", "aliases": ["down regulation of protein localisation to chromosome, telomeric region", "downregulation of protein localisation to chromosome, telomeric region", "downregulation of protein localization to telomere", "downregulation of protein localization to chromosome, telomeric region", "negative regulation of protein localisation to chromosome, telomeric region", "negative regulation of protein localization to telomere", "down regulation of protein localization to chromosome, telomeric region", "down-regulation of protein localization to chromosome, telomeric region", "down-regulation of protein localisation to chromosome, telomeric region", "down-regulation of protein localization to telomere", "down regulation of protein localization to telomere"], "types": ["T045"], "canonical_name": "negative regulation of protein localization to chromosome, telomeric region", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to chromosome, telomeric region. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455]"}
{"concept_id": "C4235726", "aliases": ["regulation of protein localisation to chromosome, telomeric region", "regulation of protein localization to telomere"], "types": ["T043"], "canonical_name": "regulation of protein localization to chromosome, telomeric region", "definition": "Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455]"}
{"concept_id": "C4235727", "aliases": ["membrane-enclosed lumen of ficolin-1-rich granule", "membrane-enclosed lumen of ficolin-1 rich granule", "ficolin-1-rich granule membrane-enclosed lumen"], "types": ["T026"], "canonical_name": "ficolin-1-rich granule lumen", "definition": "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]"}
{"concept_id": "C4235728", "aliases": ["rRNA acetylation involved in SSU-rRNA maturation"], "types": ["T045"], "canonical_name": "rRNA acetylation involved in maturation of SSU-rRNA", "definition": "Any rRNA acetylation that is involved in maturation of SSU-rRNA. [GO_REF:0000060, GOC:TermGenie, PMID:25402480]"}
{"concept_id": "C4235729", "aliases": ["up-regulation of dense core vesicle transport", "upregulation of dense core vesicle transport", "up-regulation of dense core granule transport", "positive regulation of dense core vesicle transport", "upregulation of dense core granule transport", "up regulation of dense core vesicle transport", "up regulation of dense core granule transport"], "types": ["T043"], "canonical_name": "positive regulation of dense core granule transport", "definition": "Any process that activates or increases the frequency, rate or extent of dense core granule transport. [GO_REF:0000058, GOC:TermGenie, PMID:22699897]"}
{"concept_id": "C4235730", "aliases": ["downregulation of dense core vesicle transport", "down regulation of dense core vesicle transport", "downregulation of dense core granule transport", "down regulation of dense core granule transport", "negative regulation of dense core vesicle transport", "down-regulation of dense core granule transport", "down-regulation of dense core vesicle transport"], "types": ["T043"], "canonical_name": "negative regulation of dense core granule transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport. [GO_REF:0000058, GOC:TermGenie, PMID:22699897]"}
{"concept_id": "C4235731", "aliases": ["regulation of dense core vesicle transport"], "types": ["T043"], "canonical_name": "regulation of dense core granule transport", "definition": "Any process that modulates the frequency, rate or extent of dense core granule transport. [GO_REF:0000058, GOC:TermGenie, PMID:22699897]"}
{"concept_id": "C4235732", "aliases": ["up regulation of protein amino acid oxidation", "up regulation of protein oxidation", "up-regulation of protein amino acid oxidation", "positive regulation of protein amino acid oxidation", "upregulation of protein oxidation", "upregulation of protein amino acid oxidation", "up-regulation of protein oxidation"], "types": ["T044"], "canonical_name": "positive regulation of protein oxidation", "definition": "Any process that activates or increases the frequency, rate or extent of protein oxidation. [GO_REF:0000058, GOC:TermGenie, PMID:22719267]"}
{"concept_id": "C4235733", "aliases": ["down regulation of protein oxidation", "down-regulation of protein amino acid oxidation", "down-regulation of protein oxidation", "down regulation of protein amino acid oxidation", "downregulation of protein amino acid oxidation", "negative regulation of protein amino acid oxidation", "downregulation of protein oxidation"], "types": ["T044"], "canonical_name": "negative regulation of protein oxidation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation. [GO_REF:0000058, GOC:TermGenie, PMID:22719267]"}
{"concept_id": "C4235734", "aliases": ["regulation of protein amino acid oxidation"], "types": ["T044"], "canonical_name": "regulation of protein oxidation", "definition": "Any process that modulates the frequency, rate or extent of protein oxidation. [GO_REF:0000058, GOC:TermGenie, PMID:22719267]"}
{"concept_id": "C4235737", "aliases": ["regulation of protein biosynthesis involved in cellular response to UV", "regulation of translation involved in cellular response to ultraviolet light stimulus", "regulation of translation involved in cellular response to UV radiation stimulus", "regulation of protein formation involved in cellular response to UV", "regulation of translation involved in cellular response to UV light stimulus", "regulation of protein anabolism involved in cellular response to UV", "regulation of translation involved in cellular response to ultraviolet radiation stimulus", "regulation of protein synthesis involved in cellular response to UV"], "types": ["T043"], "canonical_name": "regulation of translation involved in cellular response to UV", "definition": "Any regulation of translation that is involved in cellular response to UV. [GO_REF:0000060, GOC:TermGenie, PMID:17369398]"}
{"concept_id": "C4235738", "aliases": ["RITS complex formation"], "types": ["T043"], "canonical_name": "RITS complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a RITS complex. [GO_REF:0000079, GOC:TermGenie, PMID:26443059]"}
{"concept_id": "C4235739", "aliases": ["up regulation of neuron remodeling", "upregulation of neuron remodeling", "positive regulation of neuronal remodeling", "up-regulation of neuronal remodeling", "up regulation of neuronal remodeling", "upregulation of neuronal remodeling", "up-regulation of neuron remodeling"], "types": ["T043"], "canonical_name": "positive regulation of neuron remodeling", "definition": "Any process that activates or increases the frequency, rate or extent of neuron remodeling. [GO_REF:0000058, GOC:TermGenie, PMID:21609829]"}
{"concept_id": "C4235740", "aliases": ["negative regulation of neuronal remodeling", "down-regulation of neuron remodeling", "down regulation of neuron remodeling", "downregulation of neuronal remodeling", "down-regulation of neuronal remodeling", "downregulation of neuron remodeling", "down regulation of neuronal remodeling"], "types": ["T042"], "canonical_name": "negative regulation of neuron remodeling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neuron remodeling. [GO_REF:0000058, GOC:TermGenie, PMID:21609829]"}
{"concept_id": "C4235741", "aliases": ["regulation of neuronal remodeling"], "types": ["T043"], "canonical_name": "regulation of neuron remodeling", "definition": "Any process that modulates the frequency, rate or extent of neuron remodeling. [GO_REF:0000058, GOC:TermGenie, PMID:21609829]"}
{"concept_id": "C4235742", "aliases": ["up regulation of core promoter binding", "up-regulation of core promoter binding", "upregulation of core promoter binding"], "types": ["T045"], "canonical_name": "positive regulation of core promoter binding", "definition": "Any process that activates or increases the frequency, rate or extent of core promoter binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]"}
{"concept_id": "C4235743", "aliases": ["down-regulation of core promoter binding", "down regulation of core promoter binding", "downregulation of core promoter binding"], "types": ["T045"], "canonical_name": "negative regulation of core promoter binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]"}
{"concept_id": "C4235744", "aliases": [], "types": ["T045"], "canonical_name": "regulation of core promoter binding", "definition": "Any process that modulates the frequency, rate or extent of core promoter binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]"}
{"concept_id": "C4235745", "aliases": ["up-regulation of euchromatin binding", "up regulation of euchromatin binding", "upregulation of euchromatin binding"], "types": ["T044"], "canonical_name": "positive regulation of euchromatin binding", "definition": "Any process that activates or increases the frequency, rate or extent of euchromatin binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]"}
{"concept_id": "C4235746", "aliases": ["down regulation of euchromatin binding", "downregulation of euchromatin binding", "down-regulation of euchromatin binding"], "types": ["T044"], "canonical_name": "negative regulation of euchromatin binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]"}
{"concept_id": "C4235747", "aliases": [], "types": ["T044"], "canonical_name": "regulation of euchromatin binding", "definition": "Any process that modulates the frequency, rate or extent of euchromatin binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]"}
{"concept_id": "C4235748", "aliases": ["upregulation of Pot1 complex assembly", "up-regulation of telosome assembly", "up-regulation of Pot1-Tpz1 complex assembly", "up regulation of Pot1 complex assembly", "upregulation of shelterin complex formation", "upregulation of telosome assembly", "positive regulation of telosome assembly", "up regulation of shelterin complex formation", "up regulation of Pot1-Tpz1 complex assembly", "upregulation of Pot1-Tpz1 complex assembly", "up regulation of telosome assembly", "positive regulation of Pot1-Tpz1 complex assembly", "up-regulation of shelterin complex formation", "positive regulation of Pot1 complex assembly", "positive regulation of shelterin complex formation", "up-regulation of Pot1 complex assembly"], "types": ["T043"], "canonical_name": "positive regulation of shelterin complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of shelterin complex assembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157]"}
{"concept_id": "C4235749", "aliases": ["downregulation of Pot1 complex assembly", "down regulation of shelterin complex formation", "negative regulation of shelterin complex formation", "down regulation of Pot1 complex assembly", "downregulation of Pot1-Tpz1 complex assembly", "downregulation of shelterin complex formation", "down-regulation of shelterin complex formation", "negative regulation of telosome assembly", "negative regulation of Pot1 complex assembly", "down regulation of telosome assembly", "down-regulation of Pot1-Tpz1 complex assembly", "down regulation of Pot1-Tpz1 complex assembly", "negative regulation of Pot1-Tpz1 complex assembly", "down-regulation of telosome assembly", "down-regulation of Pot1 complex assembly", "downregulation of telosome assembly"], "types": ["T043"], "canonical_name": "negative regulation of shelterin complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of shelterin complex assembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157]"}
{"concept_id": "C4235750", "aliases": ["regulation of telosome assembly", "regulation of Pot1 complex assembly", "regulation of shelterin complex formation", "regulation of Pot1-Tpz1 complex assembly"], "types": ["T043"], "canonical_name": "regulation of shelterin complex assembly", "definition": "Any process that modulates the frequency, rate or extent of shelterin complex assembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157]"}
{"concept_id": "C4235751", "aliases": ["regulation of contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle", "regulation of cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "regulation of mitotic actomyosin contractile ring maintenance", "definition": "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring maintenance. [GO_REF:0000058, GOC:TermGenie, PMID:24115772]"}
{"concept_id": "C4235752", "aliases": ["up-regulation of asymmetric protein localization involved in cell fate determination", "upregulation of asymmetric protein localization resulting in cell fate commitment", "upregulation of asymmetric protein localization involved in cell fate determination", "up regulation of asymmetric protein localisation involved in cell fate determination", "up-regulation of asymmetric protein localization resulting in cell fate commitment", "upregulation of asymmetric protein localisation involved in cell fate determination", "up regulation of cell fate commitment, asymmetric protein localization", "upregulation of cell fate commitment, asymmetric protein localization", "positive regulation of asymmetric protein localization involved in cell fate commitment", "positive regulation of cell fate commitment, asymmetric protein localization", "up-regulation of asymmetric protein localisation involved in cell fate determination", "positive regulation of asymmetric protein localisation involved in cell fate determination", "upregulation of asymmetric protein localization involved in cell fate commitment", "up regulation of asymmetric protein localization resulting in cell fate commitment", "up regulation of asymmetric protein localization involved in cell fate commitment", "up-regulation of asymmetric protein localization involved in cell fate commitment", "positive regulation of asymmetric protein localization resulting in cell fate commitment", "up regulation of asymmetric protein localization involved in cell fate determination", "up-regulation of cell fate commitment, asymmetric protein localization"], "types": ["T043"], "canonical_name": "positive regulation of asymmetric protein localization involved in cell fate determination", "definition": "Any process that activates or increases the frequency, rate or extent of asymmetric protein localization involved in cell fate determination. [GO_REF:0000058, GOC:TermGenie, PMID:17476329]"}
{"concept_id": "C4235753", "aliases": ["down-regulation of asymmetric protein localization involved in cell fate determination", "downregulation of asymmetric protein localization resulting in cell fate commitment", "negative regulation of asymmetric protein localisation involved in cell fate determination", "down regulation of asymmetric protein localization involved in cell fate determination", "downregulation of cell fate commitment, asymmetric protein localization", "downregulation of asymmetric protein localisation involved in cell fate determination", "down regulation of asymmetric protein localization involved in cell fate commitment", "negative regulation of cell fate commitment, asymmetric protein localization", "down-regulation of asymmetric protein localisation involved in cell fate determination", "down-regulation of asymmetric protein localization involved in cell fate commitment", "down regulation of asymmetric protein localization resulting in cell fate commitment", "downregulation of asymmetric protein localization involved in cell fate commitment", "down-regulation of asymmetric protein localization resulting in cell fate commitment", "down regulation of asymmetric protein localisation involved in cell fate determination", "downregulation of asymmetric protein localization involved in cell fate determination", "negative regulation of asymmetric protein localization resulting in cell fate commitment", "down-regulation of cell fate commitment, asymmetric protein localization", "negative regulation of asymmetric protein localization involved in cell fate commitment", "down regulation of cell fate commitment, asymmetric protein localization"], "types": ["T043"], "canonical_name": "negative regulation of asymmetric protein localization involved in cell fate determination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of asymmetric protein localization involved in cell fate determination. [GO_REF:0000058, GOC:TermGenie, PMID:17476329]"}
{"concept_id": "C4235754", "aliases": ["regulation of cell fate commitment, asymmetric protein localization", "regulation of asymmetric protein localization resulting in cell fate commitment", "regulation of asymmetric protein localisation involved in cell fate determination", "regulation of asymmetric protein localization involved in cell fate commitment"], "types": ["T043"], "canonical_name": "regulation of asymmetric protein localization involved in cell fate determination", "definition": "Any process that modulates the frequency, rate or extent of asymmetric protein localization involved in cell fate determination. [GO_REF:0000058, GOC:TermGenie, PMID:17476329]"}
{"concept_id": "C4235755", "aliases": ["NLRP1 inflammasome complex formation", "NALP1 inflammasome complex formation", "NALP1 inflammasome complex assembly"], "types": ["T044"], "canonical_name": "NLRP1 inflammasome complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex. [GO_REF:0000079, GOC:TermGenie, PMID:19124602]"}
{"concept_id": "C4235756", "aliases": ["up regulation of N-methyl-D-aspartate selective glutamate receptor activity", "positive regulation of NMDA receptor", "upregulation of N-methyl-D-aspartate selective glutamate receptor activity", "up-regulation of NMDA glutamate receptor activity", "upregulation of NMDA receptor", "positive regulation of N-methyl-D-aspartate selective glutamate receptor activity", "up-regulation of N-methyl-D-aspartate selective glutamate receptor activity", "up regulation of NMDA glutamate receptor activity", "upregulation of NMDA glutamate receptor activity", "up-regulation of NMDA receptor", "up regulation of NMDA receptor"], "types": ["T043"], "canonical_name": "positive regulation of NMDA glutamate receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857]"}
{"concept_id": "C4235757", "aliases": ["down-regulation of N-methyl-D-aspartate selective glutamate receptor activity", "down-regulation of NMDA glutamate receptor activity", "down regulation of NMDA receptor", "negative regulation of N-methyl-D-aspartate selective glutamate receptor activity", "downregulation of NMDA receptor", "down regulation of N-methyl-D-aspartate selective glutamate receptor activity", "down-regulation of NMDA receptor", "down regulation of NMDA glutamate receptor activity", "downregulation of N-methyl-D-aspartate selective glutamate receptor activity", "downregulation of NMDA glutamate receptor activity", "negative regulation of NMDA receptor"], "types": ["T044"], "canonical_name": "negative regulation of NMDA glutamate receptor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857]"}
{"concept_id": "C4235758", "aliases": ["up regulation of protein localisation to centrosome", "upregulation of protein localization to centrosome", "up-regulation of protein localization to centrosome", "up-regulation of protein localisation to centrosome", "upregulation of protein localisation to centrosome", "up regulation of protein localization to centrosome", "positive regulation of protein localisation to centrosome"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to centrosome", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to centrosome. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]"}
{"concept_id": "C4235759", "aliases": ["down-regulation of protein localisation to centrosome", "downregulation of protein localisation to centrosome", "down regulation of protein localization to centrosome", "negative regulation of protein localisation to centrosome", "downregulation of protein localization to centrosome", "down regulation of protein localisation to centrosome", "down-regulation of protein localization to centrosome"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to centrosome", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]"}
{"concept_id": "C4235760", "aliases": ["regulation of protein localisation to centrosome"], "types": ["T039"], "canonical_name": "regulation of protein localization to centrosome", "definition": "Any process that modulates the frequency, rate or extent of protein localization to centrosome. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]"}
{"concept_id": "C4235761", "aliases": ["up regulation of protein localisation to cell cortex", "upregulation of protein localization to cell cortex", "up-regulation of protein localisation to cell cortex", "positive regulation of protein localisation to cell cortex", "upregulation of protein localisation to cell cortex", "up regulation of protein localization to cell cortex", "up-regulation of protein localization to cell cortex"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to cell cortex", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]"}
{"concept_id": "C4235762", "aliases": ["downregulation of protein localisation to cell cortex", "down regulation of protein localisation to cell cortex", "negative regulation of protein localisation to cell cortex", "down regulation of protein localization to cell cortex", "downregulation of protein localization to cell cortex", "down-regulation of protein localization to cell cortex", "down-regulation of protein localisation to cell cortex"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to cell cortex", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]"}
{"concept_id": "C4235763", "aliases": ["regulation of protein localisation to cell cortex"], "types": ["T043"], "canonical_name": "regulation of protein localization to cell cortex", "definition": "Any process that modulates the frequency, rate or extent of protein localization to cell cortex. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]"}
{"concept_id": "C4235764", "aliases": ["up regulation of ubiquinone biosynthetic process", "up-regulation of ubiquinone biosynthetic process", "up-regulation of coenzyme Q biosynthetic process", "positive regulation of ubiquinone synthesis", "upregulation of coenzyme Q biosynthetic process", "up-regulation of ubiquinone anabolism", "upregulation of ubiquinone biosynthesis", "upregulation of ubiquinone synthesis", "up regulation of ubiquinone biosynthesis", "positive regulation of coenzyme Q biosynthesis", "up regulation of coenzyme Q biosynthetic process", "positive regulation of ubiquinone anabolism", "upregulation of ubiquinone anabolism", "upregulation of coenzyme Q biosynthesis", "positive regulation of coenzyme Q biosynthetic process", "up regulation of ubiquinone synthesis", "up regulation of coenzyme Q biosynthesis", "up-regulation of ubiquinone biosynthesis", "up-regulation of coenzyme Q biosynthesis", "upregulation of ubiquinone biosynthetic process", "positive regulation of ubiquinone formation", "up regulation of ubiquinone formation", "up-regulation of ubiquinone synthesis", "positive regulation of ubiquinone biosynthesis", "up-regulation of ubiquinone formation", "up regulation of ubiquinone anabolism", "upregulation of ubiquinone formation"], "types": ["T044"], "canonical_name": "positive regulation of ubiquinone biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of ubiquinone biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:8125303]"}
{"concept_id": "C4235765", "aliases": ["down-regulation of ubiquinone biosynthetic process", "negative regulation of coenzyme Q biosynthetic process", "negative regulation of ubiquinone formation", "downregulation of ubiquinone formation", "negative regulation of coenzyme Q biosynthesis", "negative regulation of ubiquinone synthesis", "down-regulation of ubiquinone formation", "down regulation of coenzyme Q biosynthesis", "negative regulation of ubiquinone anabolism", "down regulation of ubiquinone synthesis", "down regulation of coenzyme Q biosynthetic process", "negative regulation of ubiquinone biosynthesis", "downregulation of ubiquinone anabolism", "down-regulation of ubiquinone synthesis", "downregulation of ubiquinone biosynthetic process", "down regulation of ubiquinone anabolism", "down regulation of ubiquinone biosynthetic process", "down regulation of ubiquinone formation", "downregulation of coenzyme Q biosynthesis", "down-regulation of coenzyme Q biosynthetic process", "down-regulation of ubiquinone biosynthesis", "downregulation of ubiquinone synthesis", "downregulation of ubiquinone biosynthesis", "downregulation of coenzyme Q biosynthetic process", "down regulation of ubiquinone biosynthesis", "down-regulation of coenzyme Q biosynthesis", "down-regulation of ubiquinone anabolism"], "types": ["T044"], "canonical_name": "negative regulation of ubiquinone biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquinone biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:8125303]"}
{"concept_id": "C4235766", "aliases": ["response to CCL4", "response to carbon tetrachloride"], "types": ["T039"], "canonical_name": "response to tetrachloromethane", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:7852267]"}
{"concept_id": "C4235767", "aliases": ["intramembranous bones morphogenesis"], "types": ["T040"], "canonical_name": "intramembranous bone morphogenesis", "definition": "The developmental process by which an intramembranous bone is generated and organized. [GO_REF:0000083, GOC:TermGenie, PMID:26399686]"}
{"concept_id": "C4235768", "aliases": ["13-methylmyristic acid binding"], "types": ["T044"], "canonical_name": "isopentadecanoic acid binding", "definition": "Binding to isopentadecanoic acid. [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]"}
{"concept_id": "C4235769", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-retinol binding", "definition": "Binding to all-trans-retinol. [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]"}
{"concept_id": "C4235770", "aliases": ["caprylic acid binding"], "types": ["T044"], "canonical_name": "octanoic acid binding", "definition": "Binding to octanoic acid. [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]"}
{"concept_id": "C4235771", "aliases": ["negative regulation of starvation-induced autophagy by TORC1 signaling", "negative regulation of autophagy in response to cellular starvation by TORC1 signal transduction", "negative regulation of non-specific autophagy by TORC1 signal transduction", "negative regulation of autophagy in response to cellular starvation by TORC1 signaling", "negative regulation of starvation-induced autophagy by TORC1 signal transduction", "negative regulation of non-specific autophagy by TORC1 signaling", "negative regulation of macroautophagy by TORC1 signal transduction"], "types": ["T043"], "canonical_name": "negative regulation of macroautophagy by TORC1 signaling", "definition": "A TORC1 signaling that results in negative regulation of macroautophagy. [GO_REF:0000063, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:23602450]"}
{"concept_id": "C4235772", "aliases": ["up regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus", "stimulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus", "positive regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus", "positive regulation of transcription from Pol II promoter involved in cellular response to maltose stimulus", "upregulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus", "activation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus", "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus"], "types": ["T045"], "canonical_name": "positive regulation of transcription from RNA polymerase II promoter in response to maltose", "definition": "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a maltose stimulus. [GO_REF:0000060, GOC:TermGenie, PMID:24224056]"}
{"concept_id": "C4235773", "aliases": ["CMA translocation complex disassembly"], "types": ["T044"], "canonical_name": "chaperone-mediated autophagy translocation complex disassembly", "definition": "The disaggregation of a chaperone-mediated autophagy translocation complex into its constituent components. [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871]"}
{"concept_id": "C4235774", "aliases": ["CMA translocation complex formation", "chaperone-mediated autophagy translocation complex formation", "CMA translocation complex assembly"], "types": ["T044"], "canonical_name": "chaperone-mediated autophagy translocation complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a chaperone-mediated autophagy translocation complex. [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871]"}
{"concept_id": "C4235775", "aliases": ["up-regulation of myofibroblast cell differentiation", "up regulation of myofibroblast cell differentiation", "upregulation of myofibroblast differentiation", "up-regulation of myofibroblast differentiation", "upregulation of myofibroblast cell differentiation", "positive regulation of myofibroblast cell differentiation", "up regulation of myofibroblast differentiation"], "types": ["T043"], "canonical_name": "positive regulation of myofibroblast differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of myofibroblast differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]"}
{"concept_id": "C4235776", "aliases": ["negative regulation of myofibroblast cell differentiation", "down regulation of myofibroblast differentiation", "downregulation of myofibroblast cell differentiation", "down regulation of myofibroblast cell differentiation", "down-regulation of myofibroblast cell differentiation", "downregulation of myofibroblast differentiation", "down-regulation of myofibroblast differentiation"], "types": ["T043"], "canonical_name": "negative regulation of myofibroblast differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]"}
{"concept_id": "C4235777", "aliases": ["regulation of myofibroblast cell differentiation"], "types": ["T043"], "canonical_name": "regulation of myofibroblast differentiation", "definition": "Any process that modulates the frequency, rate or extent of myofibroblast differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]"}
{"concept_id": "C4235778", "aliases": ["protein localisation to equatorial microtubule organizing center", "protein localisation in equatorial microtubule organizing center", "protein localization in equatorial microtubule organizing center", "protein localization to eMTOC"], "types": ["T043"], "canonical_name": "protein localization to equatorial microtubule organizing center", "definition": "A process in which a protein is transported to, or maintained in, a location within an equatorial microtubule organizing center. [GO_REF:0000087, GOC:TermGenie, PMID:16611237]"}
{"concept_id": "C4235779", "aliases": ["protein localization to post-NETO new cell tip", "protein localization to new growing cell end", "protein localisation to new growing cell tip", "protein localization to post-new end take-off new cell tip", "protein localization in new growing cell tip", "protein localization to post-NETO new cell end", "protein localisation in new growing cell tip", "protein localization to new cell tip after activation of bipolar cell growth"], "types": ["T043"], "canonical_name": "protein localization to new growing cell tip", "definition": "A process in which a protein is transported to, or maintained in, a location within a new growing cell tip. [GO_REF:0000087, GOC:TermGenie, PMID:19431238]"}
{"concept_id": "C4235780", "aliases": ["up-regulation of gut granule assembly", "up regulation of gut granule assembly", "positive regulation of gut granule biogenesis", "up regulation of gut granule formation", "up-regulation of gut granule biogenesis", "positive regulation of gut granule formation", "up regulation of gut granule biogenesis", "upregulation of gut granule biogenesis", "upregulation of gut granule formation", "upregulation of gut granule assembly", "up-regulation of gut granule formation"], "types": ["T043"], "canonical_name": "positive regulation of gut granule assembly", "definition": "Any process that activates or increases the frequency, rate or extent of gut granule assembly. [GO_REF:0000058, GOC:TermGenie, PMID:17535251]"}
{"concept_id": "C4235781", "aliases": ["down-regulation of gut granule biogenesis", "downregulation of gut granule formation", "downregulation of gut granule assembly", "down-regulation of gut granule assembly", "down-regulation of gut granule formation", "downregulation of gut granule biogenesis", "down regulation of gut granule formation", "negative regulation of gut granule biogenesis", "down regulation of gut granule biogenesis", "negative regulation of gut granule formation", "down regulation of gut granule assembly"], "types": ["T043"], "canonical_name": "negative regulation of gut granule assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gut granule assembly. [GO_REF:0000058, GOC:TermGenie, PMID:17535251]"}
{"concept_id": "C4235782", "aliases": ["regulation of gut granule biogenesis", "regulation of gut granule formation"], "types": ["T043"], "canonical_name": "regulation of gut granule assembly", "definition": "Any process that modulates the frequency, rate or extent of gut granule assembly. [GO_REF:0000058, GOC:TermGenie, PMID:17535251]"}
{"concept_id": "C4235783", "aliases": ["up-regulation of vascular smooth muscle cell migration", "up regulation of vascular associated smooth muscle cell migration", "up regulation of vascular smooth muscle cell migration", "upregulation of vascular associated smooth muscle cell migration", "up-regulation of vascular associated smooth muscle cell migration", "upregulation of vascular smooth muscle cell migration", "positive regulation of vascular smooth muscle cell migration"], "types": ["T043"], "canonical_name": "positive regulation of vascular associated smooth muscle cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]"}
{"concept_id": "C4235784", "aliases": ["down-regulation of vascular smooth muscle cell migration", "down regulation of vascular smooth muscle cell migration", "downregulation of vascular associated smooth muscle cell migration", "down-regulation of vascular associated smooth muscle cell migration", "down regulation of vascular associated smooth muscle cell migration", "downregulation of vascular smooth muscle cell migration", "negative regulation of vascular smooth muscle cell migration"], "types": ["T043"], "canonical_name": "negative regulation of vascular associated smooth muscle cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]"}
{"concept_id": "C4235785", "aliases": ["regulation of vascular smooth muscle cell migration"], "types": ["T043"], "canonical_name": "regulation of vascular associated smooth muscle cell migration", "definition": "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]"}
{"concept_id": "C4235786", "aliases": ["positive regulation of protein localisation to nucleolus", "upregulation of protein localization in nucleolus", "upregulation of protein localisation to nucleolus", "up regulation of protein localisation to nucleolus", "up regulation of protein localization to nucleolus", "up-regulation of protein localisation in nucleolus", "upregulation of protein localization to nucleolus", "upregulation of protein localisation in nucleolus", "up-regulation of protein localisation to nucleolus", "positive regulation of protein localisation in nucleolus", "up regulation of protein localization in nucleolus", "up regulation of protein localisation in nucleolus", "up-regulation of protein localization in nucleolus", "positive regulation of protein localization in nucleolus", "up-regulation of protein localization to nucleolus"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to nucleolus", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]"}
{"concept_id": "C4235787", "aliases": ["negative regulation of protein localisation to nucleolus", "down-regulation of protein localization to nucleolus", "down-regulation of protein localisation in nucleolus", "downregulation of protein localization to nucleolus", "down-regulation of protein localisation to nucleolus", "down regulation of protein localization in nucleolus", "negative regulation of protein localisation in nucleolus", "down regulation of protein localization to nucleolus", "downregulation of protein localisation in nucleolus", "down regulation of protein localisation to nucleolus", "down-regulation of protein localization in nucleolus", "downregulation of protein localisation to nucleolus", "negative regulation of protein localization in nucleolus", "down regulation of protein localisation in nucleolus", "downregulation of protein localization in nucleolus"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to nucleolus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]"}
{"concept_id": "C4235788", "aliases": ["regulation of protein localisation to nucleolus", "regulation of protein localisation in nucleolus", "regulation of protein localization in nucleolus"], "types": ["T043"], "canonical_name": "regulation of protein localization to nucleolus", "definition": "Any process that modulates the frequency, rate or extent of protein localization to nucleolus. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]"}
{"concept_id": "C4235789", "aliases": ["regulation of apoptotic cell death involved in anatomical structure development", "regulation of apoptotic programmed cell death involved in anatomical structure development", "regulation of programmed cell death by apoptosis involved in anatomical structure development", "regulation of apoptotic cell death involved in development of an anatomical structure", "regulation of apoptotic process involved in development of an anatomical structure", "regulation of apoptotic programmed cell death involved in development of an anatomical structure", "regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "regulation of apoptotic process involved in anatomical structure development"], "types": ["T043"], "canonical_name": "regulation of apoptotic process involved in development", "definition": "Any process that modulates the frequency, rate or extent of apoptotic process involved in development. [GO_REF:0000058, GOC:TermGenie, PMID:22801495]"}
{"concept_id": "C4235790", "aliases": ["up regulation of apoptotic process involved in anatomical structure development", "up regulation of apoptotic programmed cell death involved in anatomical structure development", "up-regulation of apoptotic process involved in anatomical structure development", "upregulation of apoptotic process involved in anatomical structure development", "upregulation of apoptotic process involved in development of an anatomical structure", "up regulation of apoptotic cell death involved in development of an anatomical structure", "positive regulation of apoptotic process involved in anatomical structure development", "positive regulation of apoptotic cell death involved in anatomical structure development", "positive regulation of programmed cell death by apoptosis involved in anatomical structure development", "up-regulation of apoptotic programmed cell death involved in anatomical structure development", "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "upregulation of apoptotic process involved in development", "up-regulation of apoptotic process involved in development", "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure", "upregulation of programmed cell death by apoptosis involved in anatomical structure development", "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure", "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "up-regulation of programmed cell death by apoptosis involved in anatomical structure development", "positive regulation of apoptotic cell death involved in development of an anatomical structure", "positive regulation of apoptotic process involved in development of an anatomical structure", "up regulation of programmed cell death by apoptosis involved in anatomical structure development", "up regulation of apoptotic cell death involved in anatomical structure development", "upregulation of apoptotic programmed cell death involved in development of an anatomical structure", "up-regulation of apoptotic process involved in development of an anatomical structure", "up regulation of apoptotic process involved in development", "upregulation of apoptotic programmed cell death involved in anatomical structure development", "up-regulation of apoptotic cell death involved in anatomical structure development", "up regulation of apoptotic programmed cell death involved in development of an anatomical structure", "up regulation of apoptotic process involved in development of an anatomical structure", "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "upregulation of apoptotic cell death involved in development of an anatomical structure", "up-regulation of apoptotic cell death involved in development of an anatomical structure", "positive regulation of apoptotic programmed cell death involved in anatomical structure development", "upregulation of apoptotic cell death involved in anatomical structure development", "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure"], "types": ["T043"], "canonical_name": "positive regulation of apoptotic process involved in development", "definition": "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. [GO_REF:0000058, GOC:TermGenie, PMID:22801495]"}
{"concept_id": "C4235791", "aliases": ["down-regulation of apoptotic process involved in anatomical structure development", "downregulation of apoptotic cell death involved in anatomical structure development", "down-regulation of apoptotic process involved in development", "down-regulation of apoptotic programmed cell death involved in anatomical structure development", "down regulation of programmed cell death by apoptosis involved in anatomical structure development", "down regulation of apoptotic process involved in development of an anatomical structure", "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure", "down regulation of apoptotic process involved in development", "down regulation of apoptotic process involved in anatomical structure development", "negative regulation of apoptotic process involved in development of an anatomical structure", "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure", "down-regulation of apoptotic cell death involved in anatomical structure development", "downregulation of apoptotic process involved in development of an anatomical structure", "down regulation of apoptotic programmed cell death involved in anatomical structure development", "down regulation of apoptotic programmed cell death involved in development of an anatomical structure", "downregulation of apoptotic process involved in anatomical structure development", "down regulation of apoptotic cell death involved in anatomical structure development", "negative regulation of apoptotic cell death involved in anatomical structure development", "downregulation of programmed cell death by apoptosis involved in anatomical structure development", "negative regulation of apoptotic cell death involved in development of an anatomical structure", "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "down-regulation of apoptotic process involved in development of an anatomical structure", "downregulation of apoptotic cell death involved in development of an anatomical structure", "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure", "negative regulation of programmed cell death by apoptosis involved in anatomical structure development", "downregulation of apoptotic programmed cell death involved in anatomical structure development", "downregulation of apoptotic process involved in development", "down-regulation of programmed cell death by apoptosis involved in anatomical structure development", "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "negative regulation of apoptotic process involved in anatomical structure development", "down-regulation of apoptotic cell death involved in development of an anatomical structure", "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure", "down regulation of apoptotic cell death involved in development of an anatomical structure", "downregulation of apoptotic programmed cell death involved in development of an anatomical structure", "negative regulation of apoptotic programmed cell death involved in anatomical structure development"], "types": ["T043"], "canonical_name": "negative regulation of apoptotic process involved in development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. [GO_REF:0000058, GOC:TermGenie, PMID:22801495]"}
{"concept_id": "C4235792", "aliases": ["ATG1/ULK1 kinase complex formation", "ATG1/ULK1 signaling complex formation", "ULK1-ATG13-RB1CC1 complex assembly", "ULK1-ATG13-RB1CC1 complex formation", "ATG1 kinase complex formation", "ATG1-ATG13 complex assembly", "ATG1/ULK1 signaling complex assembly", "ULK1 signaling complex assembly", "Atg1p signalling complex assembly", "ULK1-ATG13-FIP200 complex assembly", "ULK1 signaling complex formation", "ATG1-ATG13 complex formation", "ATG1 kinase complex assembly", "ULK1-ATG13-FIP200 complex formation", "Atg1p signalling complex formation"], "types": ["T044"], "canonical_name": "Atg1/ULK1 kinase complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex. [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:25139988]"}
{"concept_id": "C4235793", "aliases": ["up regulation of telomere binding", "up regulation of telomeric DNA binding", "positive regulation of telomeric repeat binding", "upregulation of telomere binding", "positive regulation of telomere binding", "up-regulation of telomeric repeat binding", "upregulation of telomeric DNA binding", "up-regulation of telomere binding", "upregulation of telomeric repeat binding", "up regulation of telomeric repeat binding", "up-regulation of telomeric DNA binding"], "types": ["T045"], "canonical_name": "positive regulation of telomeric DNA binding", "definition": "Any process that activates or increases the frequency, rate or extent of telomeric DNA binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]"}
{"concept_id": "C4235794", "aliases": ["downregulation of telomeric repeat binding", "downregulation of telomeric DNA binding", "downregulation of telomere binding", "down regulation of telomeric repeat binding", "down-regulation of telomeric repeat binding", "down regulation of telomere binding", "negative regulation of telomeric repeat binding", "down regulation of telomeric DNA binding", "down-regulation of telomeric DNA binding", "down-regulation of telomere binding", "negative regulation of telomere binding"], "types": ["T045"], "canonical_name": "negative regulation of telomeric DNA binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]"}
{"concept_id": "C4235795", "aliases": ["regulation of telomeric repeat binding", "regulation of telomere binding"], "types": ["T045"], "canonical_name": "regulation of telomeric DNA binding", "definition": "Any process that modulates the frequency, rate or extent of telomeric DNA binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]"}
{"concept_id": "C4235799", "aliases": ["vascular smooth muscle cell migration"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell migration", "definition": "The orderly movement of a vascular associated smooth muscle cell from one site to another. [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]"}
{"concept_id": "C4235800", "aliases": ["up regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase", "upregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase", "up-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase"], "types": ["T044"], "canonical_name": "positive regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase", "definition": "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase. [GO_REF:0000058, GOC:TermGenie, PMID:25416781]"}
{"concept_id": "C4235801", "aliases": ["down regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase", "down-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase", "downregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase"], "types": ["T044"], "canonical_name": "negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase. [GO_REF:0000058, GOC:TermGenie, PMID:25416781]"}
{"concept_id": "C4235802", "aliases": [], "types": ["T044"], "canonical_name": "regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase", "definition": "Any process that modulates the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase. [GO_REF:0000058, GOC:TermGenie, PMID:25416781]"}
{"concept_id": "C4235803", "aliases": ["upregulation of electron transporter activity", "up-regulation of electron transporter activity", "up regulation of electron transporter activity", "up-regulation of electron carrier activity", "up regulation of electron carrier activity", "upregulation of electron carrier activity"], "types": ["T044"], "canonical_name": "positive regulation of electron transporter activity"}
{"concept_id": "C4235804", "aliases": ["negative regulation of electron transporter activity", "down-regulation of electron carrier activity", "downregulation of electron carrier activity", "downregulation of electron transporter activity", "down regulation of electron transporter activity", "down-regulation of electron transporter activity", "down regulation of electron carrier activity"], "types": ["T044"], "canonical_name": "negative regulation of electron transfer activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of electron transfer activity. [GO_REF:0000059, GOC:TermGenie, PMID:25416781]"}
{"concept_id": "C4235805", "aliases": ["regulation of electron transporter activity"], "types": ["T044"], "canonical_name": "regulation of electron transfer activity", "definition": "Any process that modulates the frequency, rate or extent of electron transfer activity. [GO_REF:0000059, GOC:TermGenie, PMID:25416781]"}
{"concept_id": "C4235806", "aliases": ["up regulation of intestinal lipid absorption", "upregulation of intestinal lipid absorption", "up-regulation of intestinal lipid absorption"], "types": ["T044"], "canonical_name": "positive regulation of intestinal lipid absorption", "definition": "Any process that activates or increases the frequency, rate or extent of intestinal lipid absorption. [GO_REF:0000058, GOC:TermGenie, PMID:18768481]"}
{"concept_id": "C4235807", "aliases": ["down regulation of intestinal lipid absorption", "downregulation of intestinal lipid absorption", "down-regulation of intestinal lipid absorption"], "types": ["T044"], "canonical_name": "negative regulation of intestinal lipid absorption", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal lipid absorption. [GO_REF:0000058, GOC:TermGenie, PMID:18768481]"}
{"concept_id": "C4235808", "aliases": [], "types": ["T044"], "canonical_name": "regulation of intestinal lipid absorption", "definition": "Any process that modulates the frequency, rate or extent of intestinal lipid absorption. [GO_REF:0000058, GOC:TermGenie, PMID:18768481]"}
{"concept_id": "C4235809", "aliases": ["up-regulation of replicative senescence", "upregulation of replicative senescence", "up regulation of replicative senescence"], "types": ["T043"], "canonical_name": "positive regulation of replicative senescence", "definition": "Any process that activates or increases the frequency, rate or extent of replicative senescence. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142]"}
{"concept_id": "C4235810", "aliases": ["down-regulation of replicative senescence", "downregulation of replicative senescence", "down regulation of replicative senescence"], "types": ["T043"], "canonical_name": "negative regulation of replicative senescence", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of replicative senescence. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142]"}
{"concept_id": "C4235811", "aliases": [], "types": ["T043"], "canonical_name": "regulation of replicative senescence", "definition": "Any process that modulates the frequency, rate or extent of replicative senescence. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142]"}
{"concept_id": "C4235813", "aliases": ["membrane-enclosed lumen of tertiary granule", "membrane-enclosed lumen of gelatinase granule", "gelatinase granule membrane-enclosed lumen", "tertiary granule membrane-enclosed lumen"], "types": ["T026"], "canonical_name": "tertiary granule lumen", "definition": "Any membrane-enclosed lumen that is part of a tertiary granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]"}
{"concept_id": "C4235814", "aliases": ["down regulation of Frizzled-LRP5/6 complex assembly", "down-regulation of Wnt-FZD-LRP5/6 trimeric complex formation", "negative regulation of Wnt-FZD-LRP5/6 trimeric complex formation", "downregulation of Wnt-FZD-LRP5/6 trimeric complex formation", "downregulation of Frizzled-LRP5/6 complex assembly", "down-regulation of Frizzled-LRP5/6 complex assembly", "negative regulation of Wnt-FZD-LRP5/6 trimeric complex assembly", "down regulation of Wnt-FZD-LRP5/6 trimeric complex assembly", "downregulation of Wnt-FZD-LRP5/6 trimeric complex assembly", "down-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly", "down regulation of Wnt-FZD-LRP5/6 trimeric complex formation"], "types": ["T043"], "canonical_name": "negative regulation of Wnt-Frizzled-LRP5/6 complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11433302]"}
{"concept_id": "C4235818", "aliases": ["up regulation of AMPA glutamate receptor clustering", "positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering", "up-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering", "upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering", "up-regulation of AMPA glutamate receptor clustering", "up-regulation of AMPA receptor clustering", "upregulation of AMPA glutamate receptor clustering", "up regulation of AMPA receptor clustering", "upregulation of AMPA receptor clustering", "up regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering", "positive regulation of AMPA receptor clustering"], "types": ["T043"], "canonical_name": "positive regulation of AMPA glutamate receptor clustering", "definition": "Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]"}
{"concept_id": "C4235819", "aliases": ["down regulation of AMPA glutamate receptor clustering", "down-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering", "downregulation of AMPA glutamate receptor clustering", "down-regulation of AMPA glutamate receptor clustering", "negative regulation of AMPA receptor clustering", "negative regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering", "downregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering", "down regulation of AMPA receptor clustering", "downregulation of AMPA receptor clustering", "down regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering", "down-regulation of AMPA receptor clustering"], "types": ["T044"], "canonical_name": "negative regulation of AMPA glutamate receptor clustering", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor clustering. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]"}
{"concept_id": "C4235820", "aliases": ["regulation of AMPA receptor clustering", "regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering"], "types": ["T043"], "canonical_name": "regulation of AMPA glutamate receptor clustering", "definition": "Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]"}
{"concept_id": "C4235821", "aliases": ["upregulation of chaperone-mediated autophagy", "up regulation of chaperone-mediated autophagy", "up-regulation of chaperone-mediated autophagy"], "types": ["T043"], "canonical_name": "positive regulation of chaperone-mediated autophagy", "definition": "Any process that activates or increases the frequency, rate or extent of chaperone-mediated autophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]"}
{"concept_id": "C4235822", "aliases": ["down regulation of chaperone-mediated autophagy", "downregulation of chaperone-mediated autophagy", "down-regulation of chaperone-mediated autophagy"], "types": ["T043"], "canonical_name": "negative regulation of chaperone-mediated autophagy", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]"}
{"concept_id": "C4235823", "aliases": ["Axin-APC-beta-catenin-GSK3B complex binding", "BDC binding", "APC-Axin-1-beta-catenin complex binding", "beta-catenin degradation complex binding"], "types": ["T044"], "canonical_name": "beta-catenin destruction complex binding", "definition": "Binding to a beta-catenin destruction complex. [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650]"}
{"concept_id": "C4235824", "aliases": ["positive regulation of Wnt-FZD-LRP5/6 trimeric complex formation", "up regulation of Frizzled-LRP5/6 complex assembly", "positive regulation of Wnt-FZD-LRP5/6 trimeric complex assembly", "up-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly", "up regulation of Wnt-FZD-LRP5/6 trimeric complex formation", "up-regulation of Wnt-FZD-LRP5/6 trimeric complex formation", "upregulation of Wnt-FZD-LRP5/6 trimeric complex assembly", "upregulation of Frizzled-LRP5/6 complex assembly", "up regulation of Wnt-FZD-LRP5/6 trimeric complex assembly", "upregulation of Wnt-FZD-LRP5/6 trimeric complex formation", "up-regulation of Frizzled-LRP5/6 complex assembly"], "types": ["T043"], "canonical_name": "positive regulation of Wnt-Frizzled-LRP5/6 complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235825", "aliases": ["regulation of Wnt-FZD-LRP5/6 trimeric complex formation", "regulation of Wnt-FZD-LRP5/6 trimeric complex assembly"], "types": ["T043"], "canonical_name": "regulation of Wnt-Frizzled-LRP5/6 complex assembly", "definition": "Any process that modulates the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4235826", "aliases": ["up-regulation of granulosa cell of ovary apoptotic process", "up regulation of granulosa cell apoptotic process", "up regulation of granulosa cell of ovary apoptotic process", "up-regulation of granulosa cell apoptotic process", "positive regulation of granulosa cell of ovary apoptotic process", "upregulation of granulosa cell apoptotic process", "upregulation of granulosa cell of ovary apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of granulosa cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of granulosa cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19208546]"}
{"concept_id": "C4235827", "aliases": ["down regulation of granulosa cell of ovary apoptotic process", "down regulation of granulosa cell apoptotic process", "downregulation of granulosa cell apoptotic process", "down-regulation of granulosa cell of ovary apoptotic process", "down-regulation of granulosa cell apoptotic process", "downregulation of granulosa cell of ovary apoptotic process", "negative regulation of granulosa cell of ovary apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of granulosa cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19208546]"}
{"concept_id": "C4235828", "aliases": ["regulation of granulosa cell of ovary apoptotic process"], "types": ["T043"], "canonical_name": "regulation of granulosa cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of granulosa cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19208546]"}
{"concept_id": "C4235829", "aliases": ["positive regulation of vascular smooth muscle cell proliferation", "upregulation of vascular smooth muscle cell proliferation", "up regulation of VSMC proliferation", "up-regulation of vascular smooth muscle cell proliferation", "up-regulation of VSMC proliferation", "up regulation of vascular smooth muscle cell proliferation", "upregulation of VSMC proliferation", "positive regulation of VSMC proliferation"], "types": ["T043"], "canonical_name": "positive regulation of vascular associated smooth muscle cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]"}
{"concept_id": "C4235830", "aliases": ["down-regulation of VSMC proliferation", "downregulation of vascular smooth muscle cell proliferation", "downregulation of VSMC proliferation", "down regulation of vascular smooth muscle cell proliferation", "negative regulation of VSMC proliferation", "down regulation of VSMC proliferation", "negative regulation of vascular smooth muscle cell proliferation", "down-regulation of vascular smooth muscle cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of vascular associated smooth muscle cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]"}
{"concept_id": "C4235831", "aliases": ["regulation of VSMC proliferation", "regulation of vascular smooth muscle cell proliferation"], "types": ["T043"], "canonical_name": "regulation of vascular associated smooth muscle cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]"}
{"concept_id": "C4235832", "aliases": ["positive regulation of protein localization in cell-cell adherens junction", "positive regulation of protein localisation to cell-cell adherens junction"], "types": ["T044"], "canonical_name": "positive regulation of protein localisation in cell-cell adherens junction"}
{"concept_id": "C4235833", "aliases": ["downregulation of protein localization to cell-cell adherens junction", "downregulation of protein localisation to cell-cell adherens junction", "down-regulation of protein localization to cell-cell adherens junction", "down regulation of protein localisation in cell-cell adherens junction", "down-regulation of protein localisation to cell-cell adherens junction", "down regulation of protein localization to cell-cell adherens junction", "down-regulation of protein localization in cell-cell adherens junction", "down regulation of protein localization in cell-cell adherens junction", "downregulation of protein localization in cell-cell adherens junction", "down regulation of protein localisation to cell-cell adherens junction", "down-regulation of protein localisation in cell-cell adherens junction", "downregulation of protein localisation in cell-cell adherens junction", "negative regulation of protein localisation to cell-cell adherens junction", "negative regulation of protein localization in cell-cell adherens junction", "negative regulation of protein localisation in cell-cell adherens junction"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to adherens junction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237]"}
{"concept_id": "C4235834", "aliases": ["regulation of protein localization in cell-cell adherens junction", "regulation of protein localisation in cell-cell adherens junction", "regulation of protein localisation to cell-cell adherens junction"], "types": ["T043"], "canonical_name": "regulation of protein localization to adherens junction", "definition": "Any process that modulates the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237]"}
{"concept_id": "C4235835", "aliases": ["granulosa cell of ovary apoptotic process"], "types": ["T043"], "canonical_name": "granulosa cell apoptotic process", "definition": "Any apoptotic process in a granulosa cell. [GO_REF:0000085, GOC:TermGenie, PMID:19208546]"}
{"concept_id": "C4235836", "aliases": ["upregulation of acinic cell proliferation", "upregulation of acinous cell proliferation", "positive regulation of acinous cell proliferation", "up-regulation of acinous cell proliferation", "up regulation of acinar cell proliferation", "upregulation of acinar cell proliferation", "up-regulation of acinar cell proliferation", "up regulation of acinous cell proliferation", "up regulation of acinic cell proliferation", "up-regulation of acinic cell proliferation", "positive regulation of acinic cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of acinar cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:9788538]"}
{"concept_id": "C4235837", "aliases": ["down regulation of acinous cell proliferation", "down-regulation of acinous cell proliferation", "down-regulation of acinic cell proliferation", "down regulation of acinar cell proliferation", "downregulation of acinar cell proliferation", "downregulation of acinous cell proliferation", "negative regulation of acinic cell proliferation", "down regulation of acinic cell proliferation", "down-regulation of acinar cell proliferation", "negative regulation of acinous cell proliferation", "downregulation of acinic cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of acinar cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:9788538]"}
{"concept_id": "C4235838", "aliases": ["regulation of acinous cell proliferation", "regulation of acinic cell proliferation"], "types": ["T043"], "canonical_name": "regulation of acinar cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of acinar cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:9788538]"}
{"concept_id": "C4235840", "aliases": ["up-regulation of vascular smooth muscle contraction", "positive regulation of vascular smooth muscle contraction", "up regulation of vascular smooth muscle contraction", "upregulation of vascular smooth muscle contraction"], "types": ["T042"], "canonical_name": "positive regulation of vascular associated smooth muscle contraction", "definition": "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624]"}
{"concept_id": "C4235841", "aliases": ["negative regulation of vascular smooth muscle contraction", "down regulation of vascular smooth muscle contraction", "down-regulation of vascular smooth muscle contraction", "downregulation of vascular smooth muscle contraction"], "types": ["T042"], "canonical_name": "negative regulation of vascular associated smooth muscle contraction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624]"}
{"concept_id": "C4235842", "aliases": [], "types": ["T042"], "canonical_name": "midbrain morphogenesis", "definition": "The developmental process by which a midbrain is generated and organized. [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]"}
{"concept_id": "C4235843", "aliases": ["upregulation of pancreatic beta cell proliferation", "upregulation of type B pancreatic cell proliferation", "up-regulation of pancreatic B cell proliferation", "positive regulation of pancreatic B cell proliferation", "upregulation of pancreatic B cell proliferation", "up regulation of pancreatic B cell proliferation", "up-regulation of pancreatic beta cell proliferation", "positive regulation of pancreatic beta cell proliferation", "up regulation of type B pancreatic cell proliferation", "up regulation of pancreatic beta cell proliferation", "up-regulation of type B pancreatic cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of type B pancreatic cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24055447]"}
{"concept_id": "C4235844", "aliases": ["down-regulation of type B pancreatic cell proliferation", "downregulation of type B pancreatic cell proliferation", "negative regulation of pancreatic beta cell proliferation", "down regulation of pancreatic beta cell proliferation", "down-regulation of pancreatic beta cell proliferation", "downregulation of pancreatic B cell proliferation", "negative regulation of pancreatic B cell proliferation", "down-regulation of pancreatic B cell proliferation", "downregulation of pancreatic beta cell proliferation", "down regulation of pancreatic B cell proliferation", "down regulation of type B pancreatic cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of type B pancreatic cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:24055447]"}
{"concept_id": "C4235845", "aliases": ["up-regulation of cytoplasmic translational initiation", "up regulation of cytoplasmic translational initiation", "upregulation of cytoplasmic translational initiation"], "types": ["T045"], "canonical_name": "positive regulation of cytoplasmic translational initiation", "definition": "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation. [GO_REF:0000058, GOC:TermGenie, PMID:12242291]"}
{"concept_id": "C4235846", "aliases": ["downregulation of cytoplasmic translational initiation", "down regulation of cytoplasmic translational initiation", "down-regulation of cytoplasmic translational initiation"], "types": ["T043"], "canonical_name": "negative regulation of cytoplasmic translational initiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation. [GO_REF:0000058, GOC:TermGenie, PMID:12242291]"}
{"concept_id": "C4235847", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic translational initiation", "definition": "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation. [GO_REF:0000058, GOC:TermGenie, PMID:12242291]"}
{"concept_id": "C4235848", "aliases": ["up-regulation of mitotic spindle disassembly", "positive regulation of mitotic spindle degradation", "up regulation of spindle breakdown during mitosis", "up regulation of mitotic spindle catabolism", "upregulation of mitotic spindle disassembly", "up-regulation of spindle disassembly during mitosis", "up regulation of mitotic spindle disassembly", "positive regulation of spindle breakdown during mitosis", "up regulation of mitotic spindle breakdown", "positive regulation of spindle degradation during mitosis", "up-regulation of spindle breakdown during mitosis", "up-regulation of spindle degradation during mitosis", "positive regulation of spindle disassembly during mitosis", "upregulation of spindle breakdown during mitosis", "up regulation of spindle disassembly during mitosis", "up-regulation of mitotic spindle breakdown", "upregulation of mitotic spindle catabolism", "up-regulation of mitotic spindle catabolism", "up regulation of spindle degradation during mitosis", "positive regulation of mitotic spindle catabolism", "upregulation of spindle degradation during mitosis", "upregulation of spindle disassembly during mitosis", "up-regulation of mitotic spindle degradation", "positive regulation of mitotic spindle breakdown", "upregulation of mitotic spindle breakdown", "up regulation of mitotic spindle degradation", "upregulation of mitotic spindle degradation"], "types": ["T044"], "canonical_name": "positive regulation of mitotic spindle disassembly", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic spindle disassembly. [GO_REF:0000058, GOC:TermGenie, PMID:25963819]"}
{"concept_id": "C4235849", "aliases": ["regulation of mitotic spindle catabolism", "regulation of mitotic spindle breakdown", "regulation of spindle degradation during mitosis", "regulation of spindle disassembly during mitosis", "regulation of mitotic spindle degradation", "regulation of spindle breakdown during mitosis"], "types": ["T043"], "canonical_name": "regulation of mitotic spindle disassembly", "definition": "Any process that modulates the frequency, rate or extent of mitotic spindle disassembly. [GO_REF:0000058, GOC:TermGenie, PMID:25963819]"}
{"concept_id": "C4235850", "aliases": ["up regulation of metalloendopeptidase activity", "upregulation of metalloendopeptidase activity", "up-regulation of metalloendopeptidase activity"], "types": ["T044"], "canonical_name": "positive regulation of metalloendopeptidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]"}
{"concept_id": "C4235851", "aliases": ["down regulation of metalloendopeptidase activity", "down-regulation of metalloendopeptidase activity", "negative regulation of metalloendoprotease activity", "downregulation of metalloendopeptidase activity"], "types": ["T044"], "canonical_name": "negative regulation of metalloendopeptidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]"}
{"concept_id": "C4235852", "aliases": [], "types": ["T044"], "canonical_name": "regulation of metalloendopeptidase activity", "definition": "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]"}
{"concept_id": "C4235853", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to 3-methylcholanthrene", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771]"}
{"concept_id": "C4235854", "aliases": [], "types": ["T043"], "canonical_name": "response to 3-methylcholanthrene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771]"}
{"concept_id": "C4235855", "aliases": [], "types": ["T044"], "canonical_name": "peptide transmembrane transporter activity", "definition": "Enables the transfer of a peptide from one side of a membrane to the other. [GO_REF:0000070, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C4235856", "aliases": [], "types": ["T045"], "canonical_name": "alpha-aminoacyl-tRNA binding", "definition": "Binding to an alpha-aminoacyl-tRNA. [GO_REF:0000067, GOC:TermGenie, ISBN:155581073X]"}
{"concept_id": "C4235857", "aliases": ["upregulation of somatic stem cell division", "positive regulation of somatic stem cell renewal", "up-regulation of somatic stem cell division", "upregulation of somatic stem cell renewal", "up-regulation of somatic stem cell renewal", "up regulation of somatic stem cell renewal", "up regulation of somatic stem cell division"], "types": ["T043"], "canonical_name": "positive regulation of somatic stem cell division", "definition": "Any process that activates or increases the frequency, rate or extent of somatic stem cell division. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]"}
{"concept_id": "C4235858", "aliases": ["negative regulation of somatic stem cell renewal", "down regulation of somatic stem cell division", "down regulation of somatic stem cell renewal", "down-regulation of somatic stem cell renewal", "downregulation of somatic stem cell division", "down-regulation of somatic stem cell division", "downregulation of somatic stem cell renewal"], "types": ["T043"], "canonical_name": "negative regulation of somatic stem cell division", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]"}
{"concept_id": "C4235859", "aliases": ["regulation of somatic stem cell renewal"], "types": ["T043"], "canonical_name": "regulation of somatic stem cell division", "definition": "Any process that modulates the frequency, rate or extent of somatic stem cell division. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]"}
{"concept_id": "C4235860", "aliases": ["upregulation of somatic stem cell population maintenance", "up-regulation of somatic stem cell population maintenance", "up regulation of somatic stem cell population maintenance"], "types": ["T040"], "canonical_name": "positive regulation of somatic stem cell population maintenance", "definition": "Any process that activates or increases the frequency, rate or extent of somatic stem cell population maintenance. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]"}
{"concept_id": "C4235861", "aliases": ["down-regulation of somatic stem cell population maintenance", "downregulation of somatic stem cell population maintenance", "down regulation of somatic stem cell population maintenance"], "types": ["T039"], "canonical_name": "negative regulation of somatic stem cell population maintenance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]"}
{"concept_id": "C4235862", "aliases": [], "types": ["T043"], "canonical_name": "regulation of somatic stem cell population maintenance", "definition": "Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]"}
{"concept_id": "C4235863", "aliases": ["downregulation of cell differentiation involved in stem cell population maintenance", "down regulation of cell differentiation involved in stem cell population maintenance", "down-regulation of cell differentiation involved in stem cell population maintenance"], "types": ["T043"], "canonical_name": "negative regulation of cell differentiation involved in stem cell population maintenance", "definition": "Any negative regulation of cell differentiation that is involved in stem cell population maintenance. [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]"}
{"concept_id": "C4235864", "aliases": [], "types": ["T043"], "canonical_name": "actin filament polymerization involved in mitotic actomyosin contractile ring assembly", "definition": "Any actin filament polymerization that is involved in mitotic actomyosin contractile ring assembly. [GO_REF:0000060, GOC:TermGenie, PMID:24127216]"}
{"concept_id": "C4235865", "aliases": [], "types": ["T043"], "canonical_name": "ATP export", "definition": "The directed movement of ATP out of a cell or organelle. [GO_REF:0000074, GOC:TermGenie, PMID:24286344]"}
{"concept_id": "C4235866", "aliases": ["down regulation of protein ubiquitination activity", "negative regulation of protein ubiquitination activity", "down regulation of ubiquitin protein ligase activity", "negative regulation of ubiquitin ligase activity", "down-regulation of ubiquitin ligase activity", "down regulation of ubiquitin ligase activity", "downregulation of protein ubiquitination activity", "down-regulation of protein ubiquitination activity", "downregulation of ubiquitin ligase activity", "down-regulation of ubiquitin protein ligase activity", "downregulation of ubiquitin protein ligase activity"], "types": ["T044"], "canonical_name": "negative regulation of ubiquitin protein ligase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity. [GO_REF:0000059, GOC:dph, GOC:tb, GOC:TermGenie, PMID:26216882]"}
{"concept_id": "C4235867", "aliases": ["regulation of ubiquitin ligase activity", "regulation of protein ubiquitination activity"], "types": ["T044"], "canonical_name": "regulation of ubiquitin protein ligase activity", "definition": "Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882]"}
{"concept_id": "C4235868", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of N-terminal peptidyl-methionine acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-methionine acetylation. [GO_REF:0000058, GOC:TermGenie, PMID:20807799]"}
{"concept_id": "C4235869", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of N-terminal peptidyl-methionine acetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation. [GO_REF:0000058, GOC:TermGenie, PMID:20807799]"}
{"concept_id": "C4235870", "aliases": [], "types": ["T044"], "canonical_name": "regulation of N-terminal peptidyl-methionine acetylation", "definition": "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-methionine acetylation. [GO_REF:0000058, GOC:TermGenie, PMID:20807799]"}
{"concept_id": "C4235871", "aliases": ["up-regulation of sensory perception of bitter taste", "positive regulation of bitter taste perception", "upregulation of sensory perception of bitter taste", "up regulation of sensory perception of bitter taste", "upregulation of bitter taste perception", "up-regulation of bitter taste perception", "up regulation of bitter taste perception"], "types": ["T040"], "canonical_name": "positive regulation of sensory perception of bitter taste", "definition": "Any process that activates or increases the frequency, rate or extent of sensory perception of bitter taste. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]"}
{"concept_id": "C4235872", "aliases": ["down regulation of sensory perception of bitter taste", "downregulation of bitter taste perception", "down-regulation of sensory perception of bitter taste", "down-regulation of bitter taste perception", "down regulation of bitter taste perception", "downregulation of sensory perception of bitter taste", "negative regulation of bitter taste perception"], "types": ["T040"], "canonical_name": "negative regulation of sensory perception of bitter taste", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of bitter taste. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]"}
{"concept_id": "C4235873", "aliases": ["regulation of bitter taste perception"], "types": ["T040"], "canonical_name": "regulation of sensory perception of bitter taste", "definition": "Any process that modulates the frequency, rate or extent of sensory perception of bitter taste. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]"}
{"concept_id": "C4235874", "aliases": [], "types": ["T043"], "canonical_name": "glucose transmembrane transport", "definition": "The process in which glucose is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:9090050]"}
{"concept_id": "C4235875", "aliases": ["up regulation of sensory perception of sweet taste", "up-regulation of sensory perception of sweet taste", "positive regulation of sweet taste perception", "up-regulation of sweet taste perception", "up regulation of sweet taste perception", "upregulation of sensory perception of sweet taste", "upregulation of sweet taste perception"], "types": ["T040"], "canonical_name": "positive regulation of sensory perception of sweet taste", "definition": "Any process that activates or increases the frequency, rate or extent of sensory perception of sweet taste. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]"}
{"concept_id": "C4235876", "aliases": ["downregulation of sweet taste perception", "down regulation of sensory perception of sweet taste", "negative regulation of sweet taste perception", "down regulation of sweet taste perception", "down-regulation of sensory perception of sweet taste", "downregulation of sensory perception of sweet taste", "down-regulation of sweet taste perception"], "types": ["T040"], "canonical_name": "negative regulation of sensory perception of sweet taste", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of sweet taste. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]"}
{"concept_id": "C4235877", "aliases": ["regulation of sweet taste perception"], "types": ["T040"], "canonical_name": "regulation of sensory perception of sweet taste", "definition": "Any process that modulates the frequency, rate or extent of sensory perception of sweet taste. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]"}
{"concept_id": "C4235878", "aliases": ["up-regulation of alveologenesis", "up-regulation of lung alveolus development", "positive regulation of alveolarization", "up-regulation of alveolarization", "positive regulation of alveologenesis", "up regulation of lung alveolus development", "up regulation of alveolarization", "up regulation of alveologenesis", "upregulation of alveologenesis", "upregulation of lung alveolus development", "upregulation of alveolarization"], "types": ["T039"], "canonical_name": "positive regulation of lung alveolus development", "definition": "Any process that activates or increases the frequency, rate or extent of lung alveolus development. [GO_REF:0000058, GOC:TermGenie, PMID:23962064]"}
{"concept_id": "C4235879", "aliases": ["down regulation of lung alveolus development", "down regulation of alveolarization", "down regulation of alveologenesis", "down-regulation of alveologenesis", "down-regulation of alveolarization", "negative regulation of alveolarization", "downregulation of alveologenesis", "downregulation of lung alveolus development", "down-regulation of lung alveolus development", "downregulation of alveolarization", "negative regulation of alveologenesis"], "types": ["T042"], "canonical_name": "negative regulation of lung alveolus development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development. [GO_REF:0000058, GOC:TermGenie, PMID:23962064]"}
{"concept_id": "C4235880", "aliases": ["regulation of alveolarization", "regulation of alveologenesis"], "types": ["T042"], "canonical_name": "regulation of lung alveolus development", "definition": "Any process that modulates the frequency, rate or extent of lung alveolus development. [GO_REF:0000058, GOC:TermGenie, PMID:23962064]"}
{"concept_id": "C4235881", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to cell division site involved in cell separation after cytokinesis", "definition": "Any protein localization to cell division site that is involved in cell separation after cytokinesis. [GO_REF:0000060, GOC:TermGenie, PMID:25411334]"}
{"concept_id": "C4235882", "aliases": ["up regulation of adipocyte apoptotic process", "up regulation of adipose cell apoptotic process", "up-regulation of adipose cell apoptotic process", "up-regulation of adipocyte apoptotic process", "positive regulation of adipocyte apoptotic process", "upregulation of adipose cell apoptotic process", "positive regulation of adipose cell apoptotic process", "up-regulation of fat cell apoptotic process", "upregulation of fat cell apoptotic process", "upregulation of adipocyte apoptotic process", "up regulation of fat cell apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of fat cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:17024416]"}
{"concept_id": "C4235883", "aliases": ["negative regulation of adipose cell apoptotic process", "down-regulation of adipocyte apoptotic process", "down regulation of adipose cell apoptotic process", "down regulation of fat cell apoptotic process", "negative regulation of adipocyte apoptotic process", "down regulation of adipocyte apoptotic process", "downregulation of adipose cell apoptotic process", "down-regulation of adipose cell apoptotic process", "down-regulation of fat cell apoptotic process", "downregulation of fat cell apoptotic process", "downregulation of adipocyte apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of fat cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:17024416]"}
{"concept_id": "C4235884", "aliases": ["regulation of adipocyte apoptotic process", "regulation of adipose cell apoptotic process"], "types": ["T043"], "canonical_name": "regulation of fat cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of fat cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:17024416]"}
{"concept_id": "C4235885", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to rotenone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18538940]"}
{"concept_id": "C4235886", "aliases": [], "types": ["T043"], "canonical_name": "response to rotenone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18538940]"}
{"concept_id": "C4235887", "aliases": ["cellular response to beta-amyloid", "cellular response to beta-amyloids"], "types": ["T043"], "canonical_name": "cellular response to amyloid-beta", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]"}
{"concept_id": "C4235888", "aliases": ["response to beta-amyloids", "response to beta-amyloid"], "types": ["T043"], "canonical_name": "response to amyloid-beta", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]"}
{"concept_id": "C4235889", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to curcumin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24755072]"}
{"concept_id": "C4235890", "aliases": [], "types": ["T043"], "canonical_name": "response to curcumin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24755072]"}
{"concept_id": "C4235891", "aliases": ["cellular response to dinitrophenols"], "types": ["T043"], "canonical_name": "cellular response to dinitrophenol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24336883]"}
{"concept_id": "C4235892", "aliases": ["response to dinitrophenols"], "types": ["T043"], "canonical_name": "response to dinitrophenol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24336883]"}
{"concept_id": "C4235893", "aliases": [], "types": ["T043"], "canonical_name": "response to methionine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17716000]"}
{"concept_id": "C4235894", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to resveratrol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]"}
{"concept_id": "C4235895", "aliases": [], "types": ["T043"], "canonical_name": "response to resveratrol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]"}
{"concept_id": "C4235896", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to ionomycin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17516843]"}
{"concept_id": "C4235897", "aliases": [], "types": ["T043"], "canonical_name": "response to ionomycin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17516843]"}
{"concept_id": "C4235898", "aliases": ["up regulation of glomerular visceral epithelial cell apoptotic process", "positive regulation of glomerular visceral epithelial cell apoptotic process", "upregulation of glomerular visceral epithelial cell apoptotic process", "upregulation of podocyte apoptotic process", "up regulation of podocyte apoptotic process", "upregulation of glomerular podocyte apoptotic process", "up-regulation of glomerular podocyte apoptotic process", "up regulation of glomerular podocyte apoptotic process", "up-regulation of podocyte apoptotic process", "positive regulation of glomerular podocyte apoptotic process", "up-regulation of glomerular visceral epithelial cell apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of podocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:23692924]"}
{"concept_id": "C4235899", "aliases": ["downregulation of podocyte apoptotic process", "downregulation of glomerular podocyte apoptotic process", "down-regulation of podocyte apoptotic process", "down regulation of podocyte apoptotic process", "down regulation of glomerular visceral epithelial cell apoptotic process", "negative regulation of glomerular podocyte apoptotic process", "negative regulation of podocyte apoptosis", "down-regulation of glomerular visceral epithelial cell apoptotic process", "down-regulation of glomerular podocyte apoptotic process", "negative regulation of glomerular visceral epithelial cell apoptotic process", "down regulation of glomerular podocyte apoptotic process", "downregulation of glomerular visceral epithelial cell apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of podocyte apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:23692924]"}
{"concept_id": "C4235900", "aliases": ["regulation of glomerular visceral epithelial cell apoptotic process", "regulation of glomerular podocyte apoptotic process"], "types": ["T043"], "canonical_name": "regulation of podocyte apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:23692924]"}
{"concept_id": "C4235901", "aliases": ["cellular response to glucosides"], "types": ["T043"], "canonical_name": "cellular response to glucoside", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16842873]"}
{"concept_id": "C4235902", "aliases": ["response to glucosides"], "types": ["T043"], "canonical_name": "response to glucoside", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16842873]"}
{"concept_id": "C4235903", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to diterpene", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:19765580]"}
{"concept_id": "C4235904", "aliases": [], "types": ["T043"], "canonical_name": "response to diterpene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:19765580]"}
{"concept_id": "C4235905", "aliases": ["cellular response to TPA", "cellular response to tetradecanoylphorbol acetate", "cellular response to response to PMA", "cellular response to phorbol 12-tetradecanoate 13-acetate"], "types": ["T043"], "canonical_name": "cellular response to phorbol 13-acetate 12-myristate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:2200903]"}
{"concept_id": "C4235906", "aliases": ["response to tetradecanoylphorbol acetate", "response to PMA", "response to phorbol 12-tetradecanoate 13-acetate", "response to TPA"], "types": ["T043"], "canonical_name": "response to phorbol 13-acetate 12-myristate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:2200903]"}
{"concept_id": "C4235907", "aliases": ["up-regulation of glycine secretion, neurotransmission", "upregulation of glycine secretion, neurotransmission", "up regulation of glycine secretion, neurotransmission"], "types": ["T043"], "canonical_name": "positive regulation of glycine secretion, neurotransmission", "definition": "Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission. [GO_REF:0000058, GOC:TermGenie, PMID:22988142]"}
{"concept_id": "C4235908", "aliases": ["down regulation of glycine secretion, neurotransmission", "downregulation of glycine secretion, neurotransmission", "down-regulation of glycine secretion, neurotransmission"], "types": ["T043"], "canonical_name": "negative regulation of glycine secretion, neurotransmission", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission. [GO_REF:0000058, GOC:TermGenie, PMID:22988142]"}
{"concept_id": "C4235909", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glycine secretion, neurotransmission", "definition": "Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission. [GO_REF:0000058, GOC:TermGenie, PMID:22988142]"}
{"concept_id": "C4235913", "aliases": ["cellular response to DMSO"], "types": ["T043"], "canonical_name": "cellular response to dimethyl sulfoxide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12873812]"}
{"concept_id": "C4235914", "aliases": ["response to DMSO"], "types": ["T043"], "canonical_name": "response to dimethyl sulfoxide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12873812]"}
{"concept_id": "C4235915", "aliases": ["up regulation of actin binding", "up-regulation of actin binding", "upregulation of actin binding"], "types": ["T044"], "canonical_name": "positive regulation of actin binding", "definition": "Any process that activates or increases the frequency, rate or extent of actin binding. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]"}
{"concept_id": "C4235916", "aliases": ["down regulation of actin binding", "downregulation of actin binding", "down-regulation of actin binding"], "types": ["T044"], "canonical_name": "negative regulation of actin binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of actin binding. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]"}
{"concept_id": "C4235917", "aliases": [], "types": ["T044"], "canonical_name": "regulation of actin binding", "definition": "Any process that modulates the frequency, rate or extent of actin binding. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]"}
{"concept_id": "C4235918", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to biphenyl", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23196670]"}
{"concept_id": "C4235919", "aliases": [], "types": ["T043"], "canonical_name": "response to biphenyl", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23196670]"}
{"concept_id": "C4235920", "aliases": ["cellular response to TCDD", "cellular response to dioxin"], "types": ["T043"], "canonical_name": "cellular response to 2,3,7,8-tetrachlorodibenzodioxine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23196670]"}
{"concept_id": "C4235921", "aliases": ["response to TCDD", "response to dioxin"], "types": ["T043"], "canonical_name": "response to 2,3,7,8-tetrachlorodibenzodioxine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23196670]"}
{"concept_id": "C4235922", "aliases": ["cellular response to PCB 126"], "types": ["T043"], "canonical_name": "cellular response to 3,3',4,4',5-pentachlorobiphenyl", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23196670]"}
{"concept_id": "C4235923", "aliases": ["response to PCB 126"], "types": ["T043"], "canonical_name": "response to 3,3',4,4',5-pentachlorobiphenyl", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23196670]"}
{"concept_id": "C4235924", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to monosodium L-glutamate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21389115]"}
{"concept_id": "C4235925", "aliases": [], "types": ["T043"], "canonical_name": "response to monosodium L-glutamate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21389115]"}
{"concept_id": "C4235926", "aliases": ["adipose cell apoptotic process", "adipocyte apoptotic process"], "types": ["T043"], "canonical_name": "fat cell apoptotic process", "definition": "Any apoptotic process in a fat cell. [GO_REF:0000085, GOC:TermGenie, PMID:17024416]"}
{"concept_id": "C4235927", "aliases": ["positive regulation of AGE receptor activity", "up regulation of RAGE activity", "up-regulation of AGE receptor activity", "up-regulation of advanced glycation end-product receptor activity", "upregulation of advanced glycation end-product receptor activity", "positive regulation of RAGE activity", "upregulation of AGE receptor activity", "up regulation of AGE receptor activity", "upregulation of RAGE activity", "up regulation of advanced glycation end-product receptor activity", "up-regulation of RAGE activity"], "types": ["T044"], "canonical_name": "positive regulation of advanced glycation end-product receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of advanced glycation end-product receptor activity. [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878]"}
{"concept_id": "C4235928", "aliases": ["down regulation of RAGE activity", "down-regulation of advanced glycation end-product receptor activity", "negative regulation of AGE receptor activity", "negative regulation of RAGE activity", "downregulation of RAGE activity", "down regulation of AGE receptor activity", "down-regulation of AGE receptor activity", "downregulation of advanced glycation end-product receptor activity", "down regulation of advanced glycation end-product receptor activity", "downregulation of AGE receptor activity", "down-regulation of RAGE activity"], "types": ["T044"], "canonical_name": "negative regulation of advanced glycation end-product receptor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of advanced glycation end-product receptor activity. [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878]"}
{"concept_id": "C4235929", "aliases": ["regulation of AGE receptor activity", "regulation of RAGE activity"], "types": ["T044"], "canonical_name": "regulation of advanced glycation end-product receptor activity", "definition": "Any process that modulates the frequency, rate or extent of advanced glycation end-product receptor activity. [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878]"}
{"concept_id": "C4235930", "aliases": ["protein localization in actin fusion focus", "protein localisation in actin fusion focus", "protein localisation to actin fusion focus"], "types": ["T043"], "canonical_name": "protein localization to actin fusion focus", "definition": "A process in which a protein is transported to, or maintained in, a location within an actin fusion focus. [GO_REF:0000087, GOC:TermGenie, PMID:25825517]"}
{"concept_id": "C4235931", "aliases": ["actin fusion focus formation"], "types": ["T043"], "canonical_name": "actin fusion focus assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an actin fusion focus. [GO_REF:0000079, GOC:TermGenie, PMID:25825517]"}
{"concept_id": "C4235932", "aliases": [], "types": ["T044"], "canonical_name": "advanced glycation end-product binding", "definition": "Binding to advanced glycation end-product. [GO_REF:0000067, GOC:krc, GOC:TermGenie, PMID:1650387]"}
{"concept_id": "C4235933", "aliases": ["up regulation of connective tissue replacement involved in inflammatory response wound healing", "up-regulation of connective tissue replacement involved in inflammatory response wound healing", "upregulation of connective tissue replacement involved in inflammatory response wound healing"], "types": ["T039"], "canonical_name": "positive regulation of connective tissue replacement involved in inflammatory response wound healing", "definition": "Any process that activates or increases the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812]"}
{"concept_id": "C4235934", "aliases": ["down-regulation of connective tissue replacement involved in inflammatory response wound healing", "downregulation of connective tissue replacement involved in inflammatory response wound healing", "down regulation of connective tissue replacement involved in inflammatory response wound healing"], "types": ["T039"], "canonical_name": "negative regulation of connective tissue replacement involved in inflammatory response wound healing", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812]"}
{"concept_id": "C4235935", "aliases": [], "types": ["T039"], "canonical_name": "regulation of connective tissue replacement involved in inflammatory response wound healing", "definition": "Any process that modulates the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812]"}
{"concept_id": "C4235936", "aliases": ["upregulation of transcription termination from Pol II promoter", "up-regulation of termination of RNA polymerase II transcription", "positive regulation of RNA 3'-end formation by RNA polymerase II", "upregulation of RNA polymerase II transcription termination", "up regulation of termination of RNA polymerase II transcription", "up-regulation of RNA 3'-end formation by RNA polymerase II", "up-regulation of RNA polymerase II transcription termination", "up-regulation of transcription termination from Pol II promoter", "up regulation of transcription termination from Pol II promoter", "positive regulation of transcription termination from Pol II promoter", "positive regulation of transcription termination from RNA polymerase II promoter", "upregulation of termination of RNA polymerase II transcription", "positive regulation of RNA polymerase II transcription termination", "upregulation of RNA 3'-end formation by RNA polymerase II", "upregulation of transcription termination from RNA polymerase II promoter", "up regulation of RNA polymerase II transcription termination", "up-regulation of transcription termination from RNA polymerase II promoter", "up regulation of RNA 3'-end formation by RNA polymerase II", "up regulation of transcription termination from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "positive regulation of termination of RNA polymerase II transcription", "definition": "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription. [GO_REF:0000058, GOC:TermGenie, PMID:25417108]"}
{"concept_id": "C4235937", "aliases": ["regulation of transcription termination from Pol II promoter", "regulation of transcription termination from RNA polymerase II promoter", "regulation of RNA polymerase II transcription termination", "regulation of RNA 3'-end formation by RNA polymerase II"], "types": ["T045"], "canonical_name": "regulation of termination of RNA polymerase II transcription", "definition": "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription. [GO_REF:0000058, GOC:TermGenie, PMID:25417108]"}
{"concept_id": "C4235938", "aliases": [], "types": ["T044"], "canonical_name": "prostaglandin binding", "definition": "Binding to prostaglandin. [GO_REF:0000067, GOC:TermGenie, PMID:21445266]"}
{"concept_id": "C4235939", "aliases": ["upregulation of protein refolding", "up-regulation of protein refolding", "up regulation of protein refolding"], "types": ["T044"], "canonical_name": "positive regulation of protein refolding", "definition": "Any process that activates or increases the frequency, rate or extent of protein refolding. [GO_REF:0000058, GOC:TermGenie, PMID:11360998]"}
{"concept_id": "C4235940", "aliases": ["up regulation of protein import", "up-regulation of protein import", "positive regulation of protein uptake", "upregulation of protein import", "up-regulation of protein uptake", "upregulation of protein uptake", "up regulation of protein uptake"], "types": ["T043"], "canonical_name": "positive regulation of protein import", "definition": "Any process that activates or increases the frequency, rate or extent of protein import. [GO_REF:0000058, GOC:TermGenie, PMID:11406629]"}
{"concept_id": "C4235941", "aliases": ["downregulation of protein import", "downregulation of protein uptake", "down regulation of protein import", "down-regulation of protein uptake", "negative regulation of protein uptake", "down regulation of protein uptake", "down-regulation of protein import"], "types": ["T043"], "canonical_name": "negative regulation of protein import", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein import. [GO_REF:0000058, GOC:TermGenie, PMID:11406629]"}
{"concept_id": "C4235942", "aliases": ["regulation of protein uptake"], "types": ["T043"], "canonical_name": "regulation of protein import", "definition": "Any process that modulates the frequency, rate or extent of protein import. [GO_REF:0000058, GOC:TermGenie, PMID:11406629]"}
{"concept_id": "C4235943", "aliases": ["cellular response to glycoproteins"], "types": ["T043"], "canonical_name": "cellular response to glycoprotein", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:14597422]"}
{"concept_id": "C4235944", "aliases": ["response to glycoproteins"], "types": ["T043"], "canonical_name": "response to glycoprotein", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:14597422]"}
{"concept_id": "C4235945", "aliases": ["cellular response to 1,4-Diaminobutane", "cellular response to tetramethylenediamine", "cellular response to 1,4-Butanediamine"], "types": ["T043"], "canonical_name": "cellular response to putrescine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20805360]"}
{"concept_id": "C4235946", "aliases": ["response to tetramethylenediamine", "response to 1,4-Diaminobutane", "response to 1,4-Butanediamine"], "types": ["T043"], "canonical_name": "response to putrescine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20805360]"}
{"concept_id": "C4235947", "aliases": ["cellular response to polyamine", "cellular response to polyamines"], "types": ["T043"], "canonical_name": "cellular response to polyamine macromolecule", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20805360]"}
{"concept_id": "C4235948", "aliases": ["response to polyamines", "response to polyamine"], "types": ["T039"], "canonical_name": "response to polyamine macromolecule", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20805360]"}
{"concept_id": "C4235949", "aliases": ["up-regulation of mRNA localization, intracellular", "up-regulation of establishment and maintenance of intracellular RNA localization", "up regulation of intracellular mRNA localisation", "up-regulation of intracellular mRNA localisation", "up regulation of intracellular mRNA localization", "positive regulation of mRNA localization, intracellular", "positive regulation of establishment and maintenance of intracellular RNA localization", "upregulation of mRNA localization, intracellular", "up-regulation of intracellular mRNA localization", "upregulation of intracellular mRNA localization", "positive regulation of intracellular mRNA localisation", "up regulation of establishment and maintenance of intracellular RNA localization", "upregulation of establishment and maintenance of intracellular RNA localization", "upregulation of intracellular mRNA localisation", "up regulation of mRNA localization, intracellular"], "types": ["T043"], "canonical_name": "positive regulation of intracellular mRNA localization", "definition": "Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization. [GO_REF:0000058, GOC:TermGenie, PMID:21471000]"}
{"concept_id": "C4235950", "aliases": ["downregulation of mRNA localization, intracellular", "down regulation of intracellular mRNA localization", "downregulation of intracellular mRNA localisation", "negative regulation of mRNA localization, intracellular", "negative regulation of intracellular mRNA localisation", "down-regulation of establishment and maintenance of intracellular RNA localization", "downregulation of establishment and maintenance of intracellular RNA localization", "down regulation of establishment and maintenance of intracellular RNA localization", "down-regulation of intracellular mRNA localization", "down-regulation of intracellular mRNA localisation", "negative regulation of establishment and maintenance of intracellular RNA localization", "down regulation of intracellular mRNA localisation", "down regulation of mRNA localization, intracellular", "down-regulation of mRNA localization, intracellular", "downregulation of intracellular mRNA localization"], "types": ["T043"], "canonical_name": "negative regulation of intracellular mRNA localization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular mRNA localization. [GO_REF:0000058, GOC:TermGenie, PMID:21471000]"}
{"concept_id": "C4235951", "aliases": ["regulation of intracellular mRNA localisation", "regulation of mRNA localization, intracellular", "regulation of establishment and maintenance of intracellular RNA localization"], "types": ["T043"], "canonical_name": "regulation of intracellular mRNA localization", "definition": "Any process that modulates the frequency, rate or extent of intracellular mRNA localization. [GO_REF:0000058, GOC:TermGenie, PMID:21471000]"}
{"concept_id": "C4235952", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to thapsigargin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23106379]"}
{"concept_id": "C4235953", "aliases": [], "types": ["T039"], "canonical_name": "response to thapsigargin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23106379]"}
{"concept_id": "C4235954", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to tunicamycin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23106379]"}
{"concept_id": "C4235955", "aliases": [], "types": ["T043"], "canonical_name": "response to tunicamycin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23106379]"}
{"concept_id": "C4235956", "aliases": ["up-regulation of SECIS binding", "upregulation of selenocysteine insertion sequence binding", "positive regulation of SECIS binding", "up regulation of selenocysteine insertion sequence binding", "upregulation of SECIS binding", "up regulation of SECIS binding", "up-regulation of selenocysteine insertion sequence binding"], "types": ["T044"], "canonical_name": "positive regulation of selenocysteine insertion sequence binding", "definition": "Any process that activates or increases the frequency, rate or extent of selenocysteine insertion sequence binding. [GO_REF:0000059, GOC:TermGenie, PMID:19716792]"}
{"concept_id": "C4235957", "aliases": ["down-regulation of selenocysteine insertion sequence binding", "downregulation of SECIS binding", "down regulation of selenocysteine insertion sequence binding", "negative regulation of SECIS binding", "down regulation of SECIS binding", "down-regulation of SECIS binding", "downregulation of selenocysteine insertion sequence binding"], "types": ["T045"], "canonical_name": "negative regulation of selenocysteine insertion sequence binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding. [GO_REF:0000059, GOC:TermGenie, PMID:19716792]"}
{"concept_id": "C4235958", "aliases": ["regulation of SECIS binding"], "types": ["T044"], "canonical_name": "regulation of selenocysteine insertion sequence binding", "definition": "Any process that modulates the frequency, rate or extent of selenocysteine insertion sequence binding. [GO_REF:0000059, GOC:TermGenie, PMID:19716792]"}
{"concept_id": "C4235959", "aliases": ["downregulation of mRNA binding", "down regulation of mRNA binding", "down-regulation of mRNA binding"], "types": ["T044"], "canonical_name": "negative regulation of mRNA binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA binding. [GO_REF:0000059, GOC:TermGenie, PMID:19716792]"}
{"concept_id": "C4235960", "aliases": ["upregulation of selenocysteine incorporation", "up-regulation of selenocysteine incorporation", "up regulation of selenocysteine incorporation"], "types": ["T043"], "canonical_name": "positive regulation of selenocysteine incorporation", "definition": "Any process that activates or increases the frequency, rate or extent of selenocysteine incorporation. [GO_REF:0000058, GOC:TermGenie, PMID:21685449]"}
{"concept_id": "C4235961", "aliases": ["down regulation of selenocysteine incorporation", "down-regulation of selenocysteine incorporation", "downregulation of selenocysteine incorporation"], "types": ["T045"], "canonical_name": "negative regulation of selenocysteine incorporation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation. [GO_REF:0000058, GOC:TermGenie, PMID:21685449]"}
{"concept_id": "C4235962", "aliases": [], "types": ["T045"], "canonical_name": "regulation of selenocysteine incorporation", "definition": "Any process that modulates the frequency, rate or extent of selenocysteine incorporation. [GO_REF:0000058, GOC:TermGenie, PMID:21685449]"}
{"concept_id": "C4235963", "aliases": ["cellular response to wartmannin"], "types": ["T043"], "canonical_name": "cellular response to wortmannin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20629186]"}
{"concept_id": "C4235964", "aliases": ["response to wartmannin"], "types": ["T043"], "canonical_name": "response to wortmannin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20629186]"}
{"concept_id": "C4235965", "aliases": ["cellular response to oleoyl lysophosphatidic acid", "cellular response to lysophosphatidic acid", "cellular response to oleoyl-L-alpha-lysophosphatidic acid", "cellular response to 1-oleoyl lysophosphatidic acid", "cellular response to LPA"], "types": ["T043"], "canonical_name": "cellular response to 1-oleoyl-sn-glycerol 3-phosphate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12139919]"}
{"concept_id": "C4235966", "aliases": ["response to lysophosphatidic acid", "response to 1-oleoyl lysophosphatidic acid", "response to LPA", "response to oleoyl lysophosphatidic acid", "response to oleoyl-L-alpha-lysophosphatidic acid"], "types": ["T039"], "canonical_name": "response to 1-oleoyl-sn-glycerol 3-phosphate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12139919]"}
{"concept_id": "C4235967", "aliases": ["phosphatidylinositol 5-phosphate biosynthesis", "phosphatidylinositol 5-phosphate formation", "phosphatidylinositol 5-phosphate synthesis", "phosphatidylinositol 5-phosphate anabolism"], "types": ["T044"], "canonical_name": "phosphatidylinositol 5-phosphate biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of phosphatidylinositol 5-phosphate. [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588]"}
{"concept_id": "C4235968", "aliases": ["phosphatidylinositol 5-phosphate metabolism"], "types": ["T044"], "canonical_name": "phosphatidylinositol 5-phosphate metabolic process", "definition": "The chemical reactions and pathways involving phosphatidylinositol 5-phosphate. [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588]"}
{"concept_id": "C4235969", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to diphenidol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]"}
{"concept_id": "C4235970", "aliases": [], "types": ["T039"], "canonical_name": "response to diphenidol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]"}
{"concept_id": "C4235971", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to dextromethorphan", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]"}
{"concept_id": "C4235972", "aliases": [], "types": ["T039"], "canonical_name": "response to dextromethorphan", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]"}
{"concept_id": "C4235973", "aliases": [], "types": ["T043"], "canonical_name": "L-alanine transmembrane transport", "definition": "The directed movement of L-alanine across a membrane. [GO_REF:0000069, GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C4235974", "aliases": [], "types": ["T043"], "canonical_name": "L-tryptophan transmembrane transport", "definition": "The directed movement of L-tryptophan across a membrane. [GO_REF:0000069, GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C4235975", "aliases": [], "types": ["T043"], "canonical_name": "L-proline transmembrane transport", "definition": "The directed movement of L-proline across a membrane. [GO_REF:0000069, GOC:kmv, GOC:TermGenie]"}
{"concept_id": "C4235976", "aliases": ["up-regulation of chemotaxis to arachidonic acid", "up regulation of chemotaxis to arachidonic acid", "upregulation of chemotaxis to arachidonic acid"], "types": ["T043"], "canonical_name": "positive regulation of chemotaxis to arachidonic acid", "definition": "Any process that activates or increases the frequency, rate or extent of chemotaxis to arachidonic acid. [GO_REF:0000058, GOC:TermGenie, PMID:16382163]"}
{"concept_id": "C4235977", "aliases": ["downregulation of chemotaxis to arachidonic acid", "down-regulation of chemotaxis to arachidonic acid", "down regulation of chemotaxis to arachidonic acid"], "types": ["T043"], "canonical_name": "negative regulation of chemotaxis to arachidonic acid", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chemotaxis to arachidonic acid. [GO_REF:0000058, GOC:TermGenie, PMID:16382163]"}
{"concept_id": "C4235978", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chemotaxis to arachidonic acid", "definition": "Any process that modulates the frequency, rate or extent of chemotaxis to arachidonic acid. [GO_REF:0000058, GOC:TermGenie, PMID:16382163]"}
{"concept_id": "C4235979", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to arachidonic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16382163]"}
{"concept_id": "C4235980", "aliases": [], "types": ["T043"], "canonical_name": "response to arachidonic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16382163]"}
{"concept_id": "C4235981", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to glucose starvation", "definition": "Any process that modulates the frequency, rate or extent of cellular response to glucose starvation. [GO_REF:0000058, GOC:TermGenie, PMID:21118717]"}
{"concept_id": "C4235982", "aliases": ["upregulation of free ubiquitin chain polymerization", "up-regulation of free ubiquitin chain polymerization", "up regulation of free ubiquitin chain polymerization"], "types": ["T044"], "canonical_name": "positive regulation of free ubiquitin chain polymerization", "definition": "Any process that activates or increases the frequency, rate or extent of free ubiquitin chain polymerization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806]"}
{"concept_id": "C4235983", "aliases": ["downregulation of free ubiquitin chain polymerization", "down regulation of free ubiquitin chain polymerization", "down-regulation of free ubiquitin chain polymerization"], "types": ["T044"], "canonical_name": "negative regulation of free ubiquitin chain polymerization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of free ubiquitin chain polymerization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806]"}
{"concept_id": "C4235984", "aliases": [], "types": ["T044"], "canonical_name": "regulation of free ubiquitin chain polymerization", "definition": "Any process that modulates the frequency, rate or extent of free ubiquitin chain polymerization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806]"}
{"concept_id": "C4235985", "aliases": [], "types": ["T043"], "canonical_name": "fungal-type cell wall disassembly involved in conjugation with cellular fusion", "definition": "Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion. [GO_REF:0000060, GOC:TermGenie, PMID:25825517]"}
{"concept_id": "C4235986", "aliases": ["up-regulation of glycolytic process through fructose-6-phosphate", "up regulation of glycolytic process through fructose-6-phosphate", "up-regulation of glycolysis through fructose-6-phosphate", "up regulation of glycolysis through fructose-6-phosphate", "positive regulation of glycolysis through fructose-6-phosphate", "upregulation of glycolysis through fructose-6-phosphate", "upregulation of glycolytic process through fructose-6-phosphate"], "types": ["T043"], "canonical_name": "positive regulation of glycolytic process through fructose-6-phosphate", "definition": "Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate. [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C4235987", "aliases": ["down regulation of glycolysis through fructose-6-phosphate", "down-regulation of glycolysis through fructose-6-phosphate", "down regulation of glycolytic process through fructose-6-phosphate", "downregulation of glycolysis through fructose-6-phosphate", "downregulation of glycolytic process through fructose-6-phosphate", "negative regulation of glycolysis through fructose-6-phosphate", "down-regulation of glycolytic process through fructose-6-phosphate"], "types": ["T043"], "canonical_name": "negative regulation of glycolytic process through fructose-6-phosphate", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate. [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C4235988", "aliases": ["regulation of glycolysis through fructose-6-phosphate"], "types": ["T043"], "canonical_name": "regulation of glycolytic process through fructose-6-phosphate", "definition": "Any process that modulates the frequency, rate or extent of glycolytic process through fructose-6-phosphate. [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479]"}
{"concept_id": "C4235989", "aliases": ["down-regulation of mitotic telomere tethering at nuclear periphery", "downregulation of mitotic telomere tethering at nuclear periphery", "down regulation of mitotic telomere tethering at nuclear periphery"], "types": ["T045"], "canonical_name": "negative regulation of mitotic telomere tethering at nuclear periphery", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic telomere tethering at nuclear periphery. [GO_REF:0000058, GOC:TermGenie, PMID:22959349]"}
{"concept_id": "C4235990", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mitotic telomere tethering at nuclear periphery", "definition": "Any process that modulates the frequency, rate or extent of mitotic telomere tethering at nuclear periphery. [GO_REF:0000058, GOC:TermGenie, PMID:22959349]"}
{"concept_id": "C4235991", "aliases": ["upregulation of telomeric loop disassembly", "up regulation of T loop disassembly", "up regulation of telomeric loop disassembly", "up-regulation of T loop disassembly", "positive regulation of T loop disassembly", "upregulation of T loop disassembly", "up-regulation of telomeric loop disassembly"], "types": ["T045"], "canonical_name": "positive regulation of telomeric loop disassembly", "definition": "Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4235992", "aliases": ["downregulation of telomeric loop disassembly", "down regulation of T loop disassembly", "downregulation of T loop disassembly", "down-regulation of T loop disassembly", "down regulation of telomeric loop disassembly", "down-regulation of telomeric loop disassembly", "negative regulation of T loop disassembly"], "types": ["T045"], "canonical_name": "negative regulation of telomeric loop disassembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop disassembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4235993", "aliases": ["regulation of T loop disassembly"], "types": ["T045"], "canonical_name": "regulation of telomeric loop disassembly", "definition": "Any process that modulates the frequency, rate or extent of telomeric loop disassembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4235994", "aliases": ["up regulation of actin filament binding", "up-regulation of F-actin binding", "upregulation of actin filament binding", "up regulation of F-actin binding", "positive regulation of F-actin binding", "up-regulation of actin filament binding", "upregulation of F-actin binding"], "types": ["T044"], "canonical_name": "positive regulation of actin filament binding", "definition": "Any process that activates or increases the frequency, rate or extent of actin filament binding. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]"}
{"concept_id": "C4235995", "aliases": ["downregulation of F-actin binding", "downregulation of actin filament binding", "down regulation of F-actin binding", "negative regulation of F-actin binding", "down regulation of actin filament binding", "down-regulation of F-actin binding", "down-regulation of actin filament binding"], "types": ["T044"], "canonical_name": "negative regulation of actin filament binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]"}
{"concept_id": "C4235996", "aliases": ["regulation of F-actin binding"], "types": ["T044"], "canonical_name": "regulation of actin filament binding", "definition": "Any process that modulates the frequency, rate or extent of actin filament binding. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]"}
{"concept_id": "C4235997", "aliases": ["up-regulation of microtubule binding", "upregulation of microtubule binding", "up regulation of microtubule binding"], "types": ["T044"], "canonical_name": "positive regulation of microtubule binding", "definition": "Any process that activates or increases the frequency, rate or extent of microtubule binding. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]"}
{"concept_id": "C4235998", "aliases": ["down regulation of microtubule binding", "downregulation of microtubule binding", "down-regulation of microtubule binding"], "types": ["T044"], "canonical_name": "negative regulation of microtubule binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]"}
{"concept_id": "C4235999", "aliases": [], "types": ["T044"], "canonical_name": "regulation of microtubule binding", "definition": "Any process that modulates the frequency, rate or extent of microtubule binding. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]"}
{"concept_id": "C4236000", "aliases": ["up-regulation of DNA amplification", "upregulation of DNA amplification", "up regulation of DNA amplification"], "types": ["T045"], "canonical_name": "positive regulation of DNA amplification", "definition": "Any process that activates or increases the frequency, rate or extent of DNA amplification. [GO_REF:0000058, GOC:TermGenie, PMID:26195783]"}
{"concept_id": "C4236001", "aliases": ["downregulation of DNA amplification", "down-regulation of DNA amplification", "down regulation of DNA amplification"], "types": ["T045"], "canonical_name": "negative regulation of DNA amplification", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification. [GO_REF:0000058, GOC:TermGenie, PMID:26195783]"}
{"concept_id": "C4236002", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA amplification", "definition": "Any process that modulates the frequency, rate or extent of DNA amplification. [GO_REF:0000058, GOC:TermGenie, PMID:26195783]"}
{"concept_id": "C4236003", "aliases": ["positive regulation of MFB apoptotic process", "up regulation of MFB apoptotic process", "upregulation of MFB apoptotic process", "up regulation of myofibroblast cell apoptotic process", "up-regulation of myofibroblast cell apoptotic process", "upregulation of myofibroblast cell apoptotic process", "up-regulation of MFB apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of myofibroblast cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:26119034]"}
{"concept_id": "C4236004", "aliases": ["down regulation of MFB apoptotic process", "negative regulation of MFB apoptotic process", "downregulation of myofibroblast cell apoptotic process", "down-regulation of myofibroblast cell apoptotic process", "down-regulation of MFB apoptotic process", "down regulation of myofibroblast cell apoptotic process", "downregulation of MFB apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of myofibroblast cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:26119034]"}
{"concept_id": "C4236005", "aliases": ["regulation of MFB apoptotic process"], "types": ["T043"], "canonical_name": "regulation of myofibroblast cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of myofibroblast cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:26119034]"}
{"concept_id": "C4236006", "aliases": ["protein localisation to microtubule minus-end", "protein localization in microtubule minus-end", "protein localisation in microtubule minus-end"], "types": ["T043"], "canonical_name": "protein localization to microtubule minus-end", "definition": "A process in which a protein is transported to, or maintained in, a location at a microtubule minus-end. [GO_REF:0000087, GOC:TermGenie, PMID:25987607]"}
{"concept_id": "C4236007", "aliases": ["protein localisation to cytoplasmic microtubule plus-end", "protein localization in cytoplasmic microtubule plus-end", "protein localisation in cytoplasmic microtubule plus-end"], "types": ["T043"], "canonical_name": "protein localization to cytoplasmic microtubule plus-end", "definition": "A process in which a protein is transported to, or maintained in, a location at a cytoplasmic microtubule plus-end. [GO_REF:0000087, GOC:TermGenie, PMID:15772152]"}
{"concept_id": "C4236008", "aliases": [], "types": ["T044"], "canonical_name": "MgATP(2-) binding", "definition": "Binding to MgATP(2-). [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:20086079]"}
{"concept_id": "C4236009", "aliases": ["MFB apoptotic process"], "types": ["T043"], "canonical_name": "myofibroblast cell apoptotic process", "definition": "Any apoptotic process in a myofibroblast cell. [GO_REF:0000085, GOC:TermGenie, PMID:23026405]"}
{"concept_id": "C4236010", "aliases": ["upregulation of TORC2 signaling", "positive regulation of TORC2 signal transduction", "up regulation of TORC2 signaling", "up-regulation of TORC2 signaling", "up regulation of TORC2 signal transduction", "upregulation of TORC2 signal transduction", "up-regulation of TORC2 signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of TORC2 signaling", "definition": "Any process that activates or increases the frequency, rate or extent of TORC2 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25590601]"}
{"concept_id": "C4236011", "aliases": ["up-regulation of premeiotic DNA replication initiation", "up regulation of premeiotic DNA replication initiation", "up regulation of initiation of premeiotic DNA replication", "positive regulation of premeiotic DNA replication initiation", "upregulation of initiation of premeiotic DNA replication", "upregulation of premeiotic DNA replication initiation", "up-regulation of initiation of premeiotic DNA replication"], "types": ["T043"], "canonical_name": "positive regulation of initiation of premeiotic DNA replication", "definition": "Any process that activates or increases the frequency, rate or extent of initiation of premeiotic DNA replication. [GO_REF:0000058, GOC:TermGenie, PMID:25891897]"}
{"concept_id": "C4236012", "aliases": ["downregulation of premeiotic DNA replication initiation", "down regulation of initiation of premeiotic DNA replication", "down-regulation of premeiotic DNA replication initiation", "downregulation of initiation of premeiotic DNA replication", "down regulation of premeiotic DNA replication initiation", "negative regulation of premeiotic DNA replication initiation", "down-regulation of initiation of premeiotic DNA replication"], "types": ["T045"], "canonical_name": "negative regulation of initiation of premeiotic DNA replication", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of initiation of premeiotic DNA replication. [GO_REF:0000058, GOC:TermGenie, PMID:25891897]"}
{"concept_id": "C4236013", "aliases": ["regulation of premeiotic DNA replication initiation"], "types": ["T045"], "canonical_name": "regulation of initiation of premeiotic DNA replication", "definition": "Any process that modulates the frequency, rate or extent of initiation of premeiotic DNA replication. [GO_REF:0000058, GOC:TermGenie, PMID:25891897]"}
{"concept_id": "C4236014", "aliases": ["growing microtubule plus end of cytoplasmic microtubule", "microtubule plus-end of cytoplasmic microtubule", "microtubule plus end of cytoplasmic microtubule"], "types": ["T026"], "canonical_name": "cytoplasmic microtubule plus-end", "definition": "Any microtubule plus-end that is part of a cytoplasmic microtubule. [GO_REF:0000064, GOC:TermGenie, PMID:15772152]"}
{"concept_id": "C4236015", "aliases": ["up regulation of protein localization in basolateral plasma membrane", "positive regulation of protein localisation in basolateral plasma membrane", "positive regulation of protein localization in basolateral plasma membrane", "positive regulation of protein localisation to basolateral plasma membrane", "upregulation of protein localisation to basolateral plasma membrane", "upregulation of protein localisation in basolateral plasma membrane", "up regulation of protein localisation in basolateral plasma membrane", "upregulation of protein localization to basolateral plasma membrane", "up regulation of protein localisation to basolateral plasma membrane", "up regulation of protein localization to basolateral plasma membrane", "up-regulation of protein localisation in basolateral plasma membrane", "up-regulation of protein localisation to basolateral plasma membrane", "up-regulation of protein localization to basolateral plasma membrane", "upregulation of protein localization in basolateral plasma membrane", "up-regulation of protein localization in basolateral plasma membrane"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to basolateral plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to basolateral plasma membrane. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433]"}
{"concept_id": "C4236016", "aliases": ["down-regulation of protein localization to basolateral plasma membrane", "down regulation of protein localisation to basolateral plasma membrane", "down regulation of protein localisation in basolateral plasma membrane", "downregulation of protein localization to basolateral plasma membrane", "down regulation of protein localization in basolateral plasma membrane", "downregulation of protein localisation in basolateral plasma membrane", "downregulation of protein localization in basolateral plasma membrane", "negative regulation of protein localization in basolateral plasma membrane", "negative regulation of protein localisation in basolateral plasma membrane", "down regulation of protein localization to basolateral plasma membrane", "negative regulation of protein localisation to basolateral plasma membrane", "down-regulation of protein localisation to basolateral plasma membrane", "down-regulation of protein localisation in basolateral plasma membrane", "down-regulation of protein localization in basolateral plasma membrane", "downregulation of protein localisation to basolateral plasma membrane"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to basolateral plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to basolateral plasma membrane. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433]"}
{"concept_id": "C4236017", "aliases": ["regulation of protein localisation to basolateral plasma membrane", "regulation of protein localization in basolateral plasma membrane", "regulation of protein localisation in basolateral plasma membrane"], "types": ["T043"], "canonical_name": "regulation of protein localization to basolateral plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of protein localization to basolateral plasma membrane. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433]"}
{"concept_id": "C4236018", "aliases": ["up-regulation of telomere maintenance in response to DNA damage", "up regulation of telomere maintenance in response to DNA damage", "up regulation of DNA damage response, telomere maintenance", "positive regulation of DNA damage response, telomere maintenance", "upregulation of DNA damage response, telomere maintenance", "up-regulation of DNA damage response, telomere maintenance", "upregulation of telomere maintenance in response to DNA damage"], "types": ["T045"], "canonical_name": "positive regulation of telomere maintenance in response to DNA damage", "definition": "Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4236019", "aliases": ["negative regulation of DNA damage response, telomere maintenance", "down-regulation of telomere maintenance in response to DNA damage", "down-regulation of DNA damage response, telomere maintenance", "down regulation of telomere maintenance in response to DNA damage", "downregulation of telomere maintenance in response to DNA damage", "downregulation of DNA damage response, telomere maintenance", "down regulation of DNA damage response, telomere maintenance"], "types": ["T045"], "canonical_name": "negative regulation of telomere maintenance in response to DNA damage", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance in response to DNA damage. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4236020", "aliases": ["regulation of DNA damage response, telomere maintenance"], "types": ["T045"], "canonical_name": "regulation of telomere maintenance in response to DNA damage", "definition": "Any process that modulates the frequency, rate or extent of telomere maintenance in response to DNA damage. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4236021", "aliases": ["up-regulation of lipophagy", "upregulation of lipophagy", "up regulation of lipophagy"], "types": ["T043"], "canonical_name": "positive regulation of lipophagy", "definition": "Any process that activates or increases the frequency, rate or extent of lipophagy. [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]"}
{"concept_id": "C4236022", "aliases": ["down regulation of lipophagy", "down-regulation of lipophagy", "downregulation of lipophagy"], "types": ["T043"], "canonical_name": "negative regulation of lipophagy", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lipophagy. [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]"}
{"concept_id": "C4236023", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lipophagy", "definition": "Any process that modulates the frequency, rate or extent of lipophagy. [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]"}
{"concept_id": "C4236027", "aliases": ["protein localization to actomyosin contractile ring involved in mitotic cytokinesis", "protein localisation to actomyosin contractile ring involved in mitotic cytokinesis", "protein localisation to actomyosin contractile ring involved in cytokinesis after mitosis", "protein localization to actomyosin contractile ring involved in cytokinesis after mitosis"], "types": ["T043"], "canonical_name": "protein localization to mitotic actomyosin contractile ring", "definition": "Any protein localization to actomyosin contractile ring that is involved in mitotic cytokinesis. [GO_REF:0000060, GOC:TermGenie, PMID:25688133]"}
{"concept_id": "C4236028", "aliases": [], "types": ["T043"], "canonical_name": "heterochromatin assembly involved in chromatin silencing at centromere outer repeat region"}
{"concept_id": "C4236029", "aliases": ["upregulation of substance P secretion, neurotransmission", "up regulation of substance P secretion, neurotransmission", "up-regulation of substance P secretion, neurotransmission"], "types": ["T043"], "canonical_name": "positive regulation of substance P secretion, neurotransmission", "definition": "Any process that activates or increases the frequency, rate or extent of substance P secretion, neurotransmission. [GO_REF:0000058, GOC:TermGenie, PMID:15292051]"}
{"concept_id": "C4236030", "aliases": ["down-regulation of substance P secretion, neurotransmission", "down regulation of substance P secretion, neurotransmission", "downregulation of substance P secretion, neurotransmission"], "types": ["T043"], "canonical_name": "negative regulation of substance P secretion, neurotransmission", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion, neurotransmission. [GO_REF:0000058, GOC:TermGenie, PMID:15292051]"}
{"concept_id": "C4236031", "aliases": [], "types": ["T043"], "canonical_name": "regulation of substance P secretion, neurotransmission", "definition": "Any process that modulates the frequency, rate or extent of substance P secretion, neurotransmission. [GO_REF:0000058, GOC:TermGenie, PMID:15292051]"}
{"concept_id": "C4236032", "aliases": [], "types": ["T044"], "canonical_name": "tetrahydrofolyl-poly(glutamate) polymer binding", "definition": "Binding to tetrahydrofolyl-poly(glutamate) polymer. [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754]"}
{"concept_id": "C4236033", "aliases": [], "types": ["T044"], "canonical_name": "Ac-Asp-Glu binding", "definition": "Binding to Ac-Asp-Glu. [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754]"}
{"concept_id": "C4236034", "aliases": ["protein localization in ciliary transition zone", "protein localisation to ciliary transition zone", "protein localisation in ciliary transition zone"], "types": ["T043"], "canonical_name": "protein localization to ciliary transition zone", "definition": "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230]"}
{"concept_id": "C4236035", "aliases": ["negative regulation of mtUPR by down-regulation of transcription from RNA polymerase II promoter", "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from Pol II promoter", "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter", "negative regulation of mitochondrial unfolded protein response by down-regulation of transcription from RNA polymerase II promoter", "negative regulation of mitochondrial unfolded protein response by inhibition of transcription from RNA polymerase II promoter", "negative regulation of mtUPR by negative regulation of transcription from Pol II promoter", "negative regulation of mitochondrial unfolded protein response by down regulation of transcription from RNA polymerase II promoter", "negative regulation of mtUPR by inhibition of transcription from RNA polymerase II promoter", "negative regulation of mtUPR by down regulation of transcription from RNA polymerase II promoter", "negative regulation of mitochondrial unfolded protein response by downregulation of transcription from RNA polymerase II promoter", "negative regulation of mtUPR by downregulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter", "definition": "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of mitochondrial unfolded protein response. [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505]"}
{"concept_id": "C4236036", "aliases": ["regulation of reactive oxygen species metabolic process by down-regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolic process by downregulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by downregulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by inhibition of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by negative regulation of transcription from Pol II promoter", "regulation of reactive oxygen species metabolism by down regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolic process by down regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by downregulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by down-regulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by down-regulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by down regulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by negative regulation of transcription from Pol II promoter", "regulation of reactive oxygen species metabolic process by inhibition of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by inhibition of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolic process by negative regulation of transcription from Pol II promoter"], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter", "definition": "A negative regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process. [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505]"}
{"concept_id": "C4236037", "aliases": ["regulation of reactive oxygen species metabolic process by activation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by up-regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by positive regulation of transcription from Pol II promoter", "regulation of reactive oxygen species metabolic process by positive regulation of transcription from Pol II promoter", "regulation of ROS metabolic process by stimulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by up regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolic process by up-regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolic process by up regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolic process by stimulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by positive regulation of transcription from Pol II promoter", "regulation of reactive oxygen species metabolism by upregulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by activation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by up regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by activation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by up-regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolism by stimulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter", "regulation of reactive oxygen species metabolic process by upregulation of transcription from RNA polymerase II promoter", "regulation of ROS metabolic process by upregulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter", "definition": "A positive regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process. [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505]"}
{"concept_id": "C4236038", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to 17alpha-ethynylestradiol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18805421]"}
{"concept_id": "C4236039", "aliases": [], "types": ["T043"], "canonical_name": "response to 17alpha-ethynylestradiol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18805421]"}
{"concept_id": "C4236040", "aliases": [], "types": ["T042"], "canonical_name": "cloacal gland development", "definition": "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure. [GO_REF:0000094, GOC:mr, GOC:TermGenie, PMID:18805421]"}
{"concept_id": "C4236041", "aliases": [], "types": ["T044"], "canonical_name": "synthetic cannabinoid binding", "definition": "Binding to synthetic cannabinoid. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10700562]"}
{"concept_id": "C4236042", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to tetrahydrofolate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus. [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160]"}
{"concept_id": "C4236043", "aliases": [], "types": ["T043"], "canonical_name": "response to tetrahydrofolate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus. [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160]"}
{"concept_id": "C4236044", "aliases": ["up-regulation of intestinal absorption", "upregulation of intestinal absorption", "up regulation of intestinal absorption"], "types": ["T039"], "canonical_name": "positive regulation of intestinal absorption", "definition": "Any process that activates or increases the frequency, rate or extent of intestinal absorption. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]"}
{"concept_id": "C4236045", "aliases": ["downregulation of intestinal absorption", "down regulation of intestinal absorption", "down-regulation of intestinal absorption"], "types": ["T043"], "canonical_name": "negative regulation of intestinal absorption", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]"}
{"concept_id": "C4236046", "aliases": [], "types": ["T042"], "canonical_name": "regulation of intestinal absorption", "definition": "Any process that modulates the frequency, rate or extent of intestinal absorption. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]"}
{"concept_id": "C4236047", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of Ras GTPase binding"}
{"concept_id": "C4236048", "aliases": ["down regulation of small GTPase binding", "downregulation of small GTPase binding", "negative regulation of Ras GTPase binding", "down-regulation of Ras GTPase binding", "inhibition of small GTPase binding"], "types": ["T044"], "canonical_name": "negative regulation of small GTPase binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase binding. [GO_REF:0000059, GOC:TermGenie, PMID:15798216]"}
{"concept_id": "C4236049", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Ras GTPase binding"}
{"concept_id": "C4236050", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to L-dopa", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25044243]"}
{"concept_id": "C4236051", "aliases": [], "types": ["T043"], "canonical_name": "response to L-dopa", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25044243]"}
{"concept_id": "C4236052", "aliases": ["positive regulation of endothelin secretion", "up-regulation of endothelin secretion", "upregulation of endothelin secretion", "up regulation of endothelin secretion"], "types": ["T043"], "canonical_name": "positive regulation of endothelin production", "definition": "Any process that activates or increases the frequency, rate or extent of endothelin production. [GO_REF:0000058, GOC:TermGenie, PMID:15560120]"}
{"concept_id": "C4236053", "aliases": ["downregulation of endothelin secretion", "negative regulation of endothelin secretion", "down-regulation of endothelin secretion", "down regulation of endothelin secretion"], "types": ["T043"], "canonical_name": "negative regulation of endothelin production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelin production. [GO_REF:0000058, GOC:TermGenie, PMID:15560120]"}
{"concept_id": "C4236054", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endothelin secretion"}
{"concept_id": "C4236058", "aliases": ["positive regulation of MMP secretion", "upregulation of MMP secretion", "up-regulation of MMP secretion", "up-regulation of matrix metallopeptidase secretion", "upregulation of matrix metallopeptidase secretion", "up regulation of matrix metallopeptidase secretion", "up regulation of MMP secretion"], "types": ["T043"], "canonical_name": "positive regulation of matrix metallopeptidase secretion", "definition": "Any process that activates or increases the frequency, rate or extent of matrix metallopeptidase secretion. [GO_REF:0000058, GOC:TermGenie, PMID:8679543]"}
{"concept_id": "C4236059", "aliases": ["downregulation of MMP secretion", "down-regulation of MMP secretion", "down-regulation of matrix metallopeptidase secretion", "down regulation of MMP secretion", "downregulation of matrix metallopeptidase secretion", "negative regulation of MMP secretion", "down regulation of matrix metallopeptidase secretion"], "types": ["T043"], "canonical_name": "negative regulation of matrix metallopeptidase secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion. [GO_REF:0000058, GOC:TermGenie, PMID:8679543]"}
{"concept_id": "C4236060", "aliases": ["regulation of MMP secretion"], "types": ["T043"], "canonical_name": "regulation of matrix metallopeptidase secretion", "definition": "Any process that modulates the frequency, rate or extent of matrix metallopeptidase secretion. [GO_REF:0000058, GOC:TermGenie, PMID:8679543]"}
{"concept_id": "C4236061", "aliases": ["ergosteryl 3-beta-D-glucoside biosynthesis", "ergosteryl 3-beta-D-glucoside anabolism", "ergosteryl 3-beta-D-glucoside synthesis", "ergosteryl 3-beta-D-glucoside formation"], "types": ["T044"], "canonical_name": "ergosteryl 3-beta-D-glucoside biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ergosteryl 3-beta-D-glucoside. [GO_REF:0000068, GOC:TermGenie, PMID:26116408]"}
{"concept_id": "C4236062", "aliases": ["ergosteryl 3-beta-D-glucoside degradation", "ergosteryl 3-beta-D-glucoside breakdown", "ergosteryl 3-beta-D-glucoside catabolism"], "types": ["T044"], "canonical_name": "ergosteryl 3-beta-D-glucoside catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside. [GO_REF:0000068, GOC:TermGenie, PMID:26116408]"}
{"concept_id": "C4236063", "aliases": ["ergosteryl 3-beta-D-glucoside metabolism"], "types": ["T044"], "canonical_name": "ergosteryl 3-beta-D-glucoside metabolic process", "definition": "The chemical reactions and pathways involving ergosteryl 3-beta-D-glucoside. [GO_REF:0000068, GOC:TermGenie, PMID:26116408]"}
{"concept_id": "C4236064", "aliases": ["up regulation of substance P secretion", "up-regulation of substance P secretion", "upregulation of substance P secretion"], "types": ["T043"], "canonical_name": "positive regulation of substance P secretion", "definition": "Any process that activates or increases the frequency, rate or extent of substance P secretion. [GO_REF:0000058, GOC:TermGenie, PMID:11278900]"}
{"concept_id": "C4236065", "aliases": ["downregulation of substance P secretion", "down-regulation of substance P secretion", "down regulation of substance P secretion"], "types": ["T043"], "canonical_name": "negative regulation of substance P secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion. [GO_REF:0000058, GOC:TermGenie, PMID:11278900]"}
{"concept_id": "C4236066", "aliases": [], "types": ["T038"], "canonical_name": "regulation of substance P secretion", "definition": "Any process that modulates the frequency, rate or extent of substance P secretion. [GO_REF:0000058, GOC:TermGenie, PMID:11278900]"}
{"concept_id": "C4236067", "aliases": ["upregulation of neuronal action potential", "up regulation of neuronal action potential", "up-regulation of neuronal action potential"], "types": ["T043"], "canonical_name": "positive regulation of neuronal action potential", "definition": "Any process that activates or increases the frequency, rate or extent of neuronal action potential. [GO_REF:0000058, GOC:TermGenie, PMID:25126967]"}
{"concept_id": "C4236068", "aliases": ["down regulation of neuronal action potential", "down-regulation of neuronal action potential", "downregulation of neuronal action potential"], "types": ["T043"], "canonical_name": "negative regulation of neuronal action potential", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. [GO_REF:0000058, GOC:TermGenie, PMID:25126967]"}
{"concept_id": "C4236069", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin-specific protease activity involved in positive regulation of ERAD pathway"}
{"concept_id": "C4236070", "aliases": ["up-regulation of H+-K+-ATPase activity", "positive regulation of H,K-ATPase activity", "up regulation of hydrogen/potassium-exchanging ATPase activity", "upregulation of H+/K+-ATPase activity", "up-regulation of (K+ + H+)-ATPase activity", "up regulation of (K+ + H+)-ATPase activity", "up regulation of H+/K+-ATPase activity", "up regulation of H(+)/K(+)-ATPase activity", "upregulation of hydrogen/potassium-exchanging ATPase activity", "up-regulation of H(+)/K(+)-ATPase activity", "positive regulation of H+/K+-ATPase activity", "upregulation of H(+)/K(+)-ATPase activity", "positive regulation of H+/K+-exchanging ATPase activity", "positive regulation of hydrogen:potassium exchanging ATPase activity", "positive regulation of H(+)/K(+)-ATPase activity", "up-regulation of hydrogen:potassium exchanging ATPase activity", "up regulation of H+-K+-ATPase activity", "up-regulation of hydrogen:potassium-exchanging ATPase activity", "upregulation of (K+ + H+)-ATPase activity", "up regulation of H(+)/K(+)-exchanging ATPase activity", "upregulation of H+-K+-ATPase activity", "up-regulation of ATP phosphohydrolase (H+/K+-exchanging)", "upregulation of hydrogen:potassium exchanging ATPase activity", "upregulation of H(+)/K(+)-exchanging ATPase activity", "up regulation of ATP phosphohydrolase (H+/K+-exchanging)", "positive regulation of H+-K+-ATPase activity", "positive regulation of hydrogen/potassium-exchanging ATPase activity", "upregulation of hydrogen:potassium-exchanging ATPase activity", "positive regulation of hydrogen:potassium-exchanging ATPase activity", "up-regulation of H,K-ATPase activity", "up regulation of hydrogen:potassium exchanging ATPase activity", "up-regulation of H+/K+-ATPase activity", "upregulation of ATP phosphohydrolase (H+/K+-exchanging)", "up-regulation of H(+)/K(+)-exchanging ATPase activity", "positive regulation of ATP phosphohydrolase (H+/K+-exchanging)", "upregulation of H+/K+-exchanging ATPase activity", "up regulation of hydrogen:potassium-exchanging ATPase activity", "up-regulation of H+/K+-exchanging ATPase activity", "upregulation of H,K-ATPase activity", "up-regulation of hydrogen/potassium-exchanging ATPase activity", "positive regulation of H(+)/K(+)-exchanging ATPase activity", "positive regulation of (K+ + H+)-ATPase activity", "up regulation of H,K-ATPase activity", "up regulation of H+/K+-exchanging ATPase activity"], "types": ["T044"], "canonical_name": "positive regulation of potassium:proton exchanging ATPase activity", "definition": "Any process that activates or increases the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity. [GO_REF:0000059, GOC:TermGenie, PMID:11897793]"}
{"concept_id": "C4236071", "aliases": ["downregulation of H(+)/K(+)-exchanging ATPase activity", "down-regulation of hydrogen:potassium exchanging ATPase activity", "down-regulation of ATP phosphohydrolase (H+/K+-exchanging)", "downregulation of hydrogen/potassium-exchanging ATPase activity", "down regulation of hydrogen/potassium-exchanging ATPase activity", "downregulation of hydrogen:potassium-exchanging ATPase activity", "downregulation of hydrogen:potassium exchanging ATPase activity", "down-regulation of H+/K+-ATPase activity", "downregulation of H+-K+-ATPase activity", "down-regulation of H+/K+-exchanging ATPase activity", "down regulation of ATP phosphohydrolase (H+/K+-exchanging)", "down-regulation of hydrogen/potassium-exchanging ATPase activity", "down regulation of H+-K+-ATPase activity", "down regulation of H(+)/K(+)-exchanging ATPase activity", "negative regulation of H+-K+-ATPase activity", "downregulation of H,K-ATPase activity", "down regulation of H,K-ATPase activity", "negative regulation of H(+)/K(+)-exchanging ATPase activity", "down regulation of hydrogen:potassium exchanging ATPase activity", "negative regulation of H,K-ATPase activity", "down regulation of H+/K+-ATPase activity", "down regulation of H+/K+-exchanging ATPase activity", "downregulation of H(+)/K(+)-ATPase activity", "down-regulation of hydrogen:potassium-exchanging ATPase activity", "down-regulation of (K+ + H+)-ATPase activity", "down regulation of hydrogen:potassium-exchanging ATPase activity", "down-regulation of H(+)/K(+)-ATPase activity", "down regulation of H(+)/K(+)-ATPase activity", "downregulation of (K+ + H+)-ATPase activity", "down regulation of (K+ + H+)-ATPase activity", "downregulation of ATP phosphohydrolase (H+/K+-exchanging)", "down-regulation of H(+)/K(+)-exchanging ATPase activity", "negative regulation of hydrogen/potassium-exchanging ATPase activity", "negative regulation of (K+ + H+)-ATPase activity", "down-regulation of H,K-ATPase activity", "downregulation of H+/K+-ATPase activity", "negative regulation of hydrogen:potassium exchanging ATPase activity", "negative regulation of ATP phosphohydrolase (H+/K+-exchanging)", "negative regulation of H(+)/K(+)-ATPase activity", "negative regulation of H+/K+-exchanging ATPase activity", "negative regulation of H+/K+-ATPase activity", "downregulation of H+/K+-exchanging ATPase activity", "down-regulation of H+-K+-ATPase activity", "negative regulation of hydrogen:potassium-exchanging ATPase activity"], "types": ["T044"], "canonical_name": "negative regulation of potassium:proton exchanging ATPase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity. [GO_REF:0000059, GOC:TermGenie, PMID:11897793]"}
{"concept_id": "C4236072", "aliases": ["regulation of H(+)/K(+)-ATPase activity", "regulation of H+/K+-ATPase activity", "regulation of hydrogen:potassium exchanging ATPase activity", "regulation of ATP phosphohydrolase (H+/K+-exchanging)", "regulation of H+-K+-ATPase activity", "regulation of H,K-ATPase activity", "regulation of hydrogen/potassium-exchanging ATPase activity", "regulation of H+/K+-exchanging ATPase activity", "regulation of H(+)/K(+)-exchanging ATPase activity", "regulation of hydrogen:potassium-exchanging ATPase activity", "regulation of (K+ + H+)-ATPase activity"], "types": ["T044"], "canonical_name": "regulation of potassium:proton exchanging ATPase activity", "definition": "Any process that modulates the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity. [GO_REF:0000059, GOC:TermGenie, PMID:11897793]"}
{"concept_id": "C4236073", "aliases": ["upregulation of aspartate secretion", "up-regulation of aspartate secretion", "up regulation of aspartate secretion"], "types": ["T044"], "canonical_name": "positive regulation of aspartate secretion", "definition": "Any process that activates or increases the frequency, rate or extent of aspartate secretion. [GO_REF:0000058, GOC:TermGenie, PMID:2342602]"}
{"concept_id": "C4236074", "aliases": ["downregulation of aspartate secretion", "down regulation of aspartate secretion", "down-regulation of aspartate secretion"], "types": ["T044"], "canonical_name": "negative regulation of aspartate secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aspartate secretion. [GO_REF:0000058, GOC:TermGenie, PMID:2342602]"}
{"concept_id": "C4236075", "aliases": [], "types": ["T044"], "canonical_name": "regulation of aspartate secretion", "definition": "Any process that modulates the frequency, rate or extent of aspartate secretion. [GO_REF:0000058, GOC:TermGenie, PMID:2342602]"}
{"concept_id": "C4236076", "aliases": ["folate import into cell", "folic acid import across plasma membrane"], "types": ["T043"], "canonical_name": "folate import across plasma membrane", "definition": "The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:19762432]"}
{"concept_id": "C4236077", "aliases": ["up regulation of establishment of BTB", "positive regulation of establishment of BTB", "positive regulation of establishment of SCB", "up-regulation of establishment of BTB", "up regulation of establishment of Sertoli cell barrier", "upregulation of establishment of BTB", "up-regulation of establishment of blood-testis barrier", "positive regulation of establishment of blood-testis barrier", "up regulation of establishment of SCB", "upregulation of establishment of SCB", "upregulation of establishment of Sertoli cell barrier", "up-regulation of establishment of Sertoli cell barrier", "upregulation of establishment of blood-testis barrier", "up-regulation of establishment of SCB", "up regulation of establishment of blood-testis barrier"], "types": ["T043"], "canonical_name": "positive regulation of establishment of Sertoli cell barrier", "definition": "Any process that activates or increases the frequency, rate or extent of establishment of Sertoli cell barrier. [GO_REF:0000058, GOC:TermGenie, PMID:18057314]"}
{"concept_id": "C4236078", "aliases": ["negative regulation of establishment of blood-testis barrier", "down-regulation of establishment of Sertoli cell barrier", "downregulation of establishment of SCB", "negative regulation of establishment of SCB", "down regulation of establishment of SCB", "down regulation of establishment of Sertoli cell barrier", "down-regulation of establishment of blood-testis barrier", "downregulation of establishment of Sertoli cell barrier", "down-regulation of establishment of BTB", "down regulation of establishment of blood-testis barrier", "down-regulation of establishment of SCB", "down regulation of establishment of BTB", "negative regulation of establishment of BTB", "downregulation of establishment of BTB", "downregulation of establishment of blood-testis barrier"], "types": ["T043"], "canonical_name": "negative regulation of establishment of Sertoli cell barrier", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of Sertoli cell barrier. [GO_REF:0000058, GOC:TermGenie, PMID:18057314]"}
{"concept_id": "C4236079", "aliases": ["regulation of establishment of blood-testis barrier", "regulation of establishment of SCB", "regulation of establishment of BTB"], "types": ["T043"], "canonical_name": "regulation of establishment of Sertoli cell barrier", "definition": "Any process that modulates the frequency, rate or extent of establishment of Sertoli cell barrier. [GO_REF:0000058, GOC:TermGenie, PMID:18057314]"}
{"concept_id": "C4236080", "aliases": ["up-regulation of thyroid gland epithelial cell proliferation", "upregulation of thyroid gland epithelial cell proliferation", "up regulation of thyroid gland epithelial cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of thyroid gland epithelial cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:17646383]"}
{"concept_id": "C4236081", "aliases": ["down regulation of thyroid gland epithelial cell proliferation", "downregulation of thyroid gland epithelial cell proliferation", "down-regulation of thyroid gland epithelial cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of thyroid gland epithelial cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid gland epithelial cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:17646383]"}
{"concept_id": "C4236082", "aliases": [], "types": ["T043"], "canonical_name": "regulation of thyroid gland epithelial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of thyroid gland epithelial cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:17646383]"}
{"concept_id": "C4236083", "aliases": ["up-regulation of ferrous iron import across plasma membrane", "upregulation of ferrous ion import into cell", "upregulation of ferrous iron import across plasma membrane", "up-regulation of ferrous ion import into cell", "up regulation of ferrous ion import into cell", "up regulation of ferrous iron import across plasma membrane", "positive regulation of ferrous ion import into cell"], "types": ["T043"], "canonical_name": "positive regulation of ferrous iron import across plasma membrane"}
{"concept_id": "C4236084", "aliases": ["down regulation of ferrous ion import into cell", "down-regulation of ferrous iron import across plasma membrane", "down-regulation of ferrous ion import into cell", "downregulation of ferrous ion import into cell", "down regulation of ferrous iron import across plasma membrane", "negative regulation of ferrous ion import into cell", "downregulation of ferrous iron import across plasma membrane"], "types": ["T043"], "canonical_name": "negative regulation of ferrous iron import across plasma membrane"}
{"concept_id": "C4236085", "aliases": ["regulation of ferrous iron import into cell", "regulation of ferrous ion import into cell"], "types": ["T043"], "canonical_name": "regulation of ferrous iron import across plasma membrane"}
{"concept_id": "C4236086", "aliases": ["up-regulation of transferrin receptor binding", "up regulation of transferrin receptor binding", "upregulation of transferrin receptor binding"], "types": ["T044"], "canonical_name": "positive regulation of transferrin receptor binding", "definition": "Any process that activates or increases the frequency, rate or extent of transferrin receptor binding. [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]"}
{"concept_id": "C4236087", "aliases": ["downregulation of transferrin receptor binding", "down-regulation of transferrin receptor binding", "down regulation of transferrin receptor binding"], "types": ["T044"], "canonical_name": "negative regulation of transferrin receptor binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding. [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]"}
{"concept_id": "C4236088", "aliases": [], "types": ["T044"], "canonical_name": "regulation of transferrin receptor binding", "definition": "Any process that modulates the frequency, rate or extent of transferrin receptor binding. [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]"}
{"concept_id": "C4236089", "aliases": ["upregulation of ferrous iron binding", "up regulation of ferrous iron binding", "up-regulation of ferrous iron binding"], "types": ["T044"], "canonical_name": "positive regulation of ferrous iron binding", "definition": "Any process that activates or increases the frequency, rate or extent of ferrous iron binding. [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]"}
{"concept_id": "C4236090", "aliases": ["down regulation of ferrous iron binding", "down-regulation of ferrous iron binding", "downregulation of ferrous iron binding"], "types": ["T044"], "canonical_name": "negative regulation of ferrous iron binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron binding. [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]"}
{"concept_id": "C4236091", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ferrous iron binding", "definition": "Any process that modulates the frequency, rate or extent of ferrous iron binding. [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]"}
{"concept_id": "C4236092", "aliases": ["up-regulation of t-circle formation", "up regulation of telomeric circle formation", "up-regulation of telomeric circle formation", "positive regulation of telomeric circle formation", "up regulation of t-circle formation", "upregulation of telomeric circle formation", "upregulation of t-circle formation"], "types": ["T045"], "canonical_name": "positive regulation of t-circle formation", "definition": "Any process that activates or increases the frequency, rate or extent of t-circle formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4236093", "aliases": ["down regulation of telomeric circle formation", "downregulation of telomeric circle formation", "down-regulation of telomeric circle formation", "down regulation of t-circle formation", "downregulation of t-circle formation", "down-regulation of t-circle formation", "negative regulation of telomeric circle formation"], "types": ["T045"], "canonical_name": "negative regulation of t-circle formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4236094", "aliases": ["regulation of telomeric circle formation"], "types": ["T045"], "canonical_name": "regulation of t-circle formation", "definition": "Any process that modulates the frequency, rate or extent of t-circle formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4236095", "aliases": ["down regulation of tubulin deacetylation", "downregulation of tubulin deacetylation", "down-regulation of tubulin deacetylation"], "types": ["T044"], "canonical_name": "negative regulation of tubulin deacetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation. [GO_REF:0000058, GOC:TermGenie, PMID:23886946]"}
{"concept_id": "C4236096", "aliases": ["up-regulation of transmembrane calcium transport", "up regulation of calcium ion membrane transport", "up-regulation of calcium ion transmembrane transport", "upregulation of calcium ion membrane transport", "upregulation of calcium ion transmembrane transport", "upregulation of transmembrane calcium transport", "up regulation of calcium ion transmembrane transport", "positive regulation of transmembrane calcium transport", "up regulation of transmembrane calcium transport", "up-regulation of calcium ion membrane transport", "positive regulation of calcium ion membrane transport"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:22910094]"}
{"concept_id": "C4236097", "aliases": ["up-regulation of GTP binding", "upregulation of GTP binding", "up regulation of GTP binding"], "types": ["T044"], "canonical_name": "positive regulation of GTP binding", "definition": "Any process that activates or increases the frequency, rate or extent of GTP binding. [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]"}
{"concept_id": "C4236098", "aliases": ["down-regulation of GTP binding", "downregulation of GTP binding", "down regulation of GTP binding"], "types": ["T044"], "canonical_name": "negative regulation of GTP binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding. [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]"}
{"concept_id": "C4236099", "aliases": [], "types": ["T044"], "canonical_name": "regulation of GTP binding", "definition": "Any process that modulates the frequency, rate or extent of GTP binding. [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]"}
{"concept_id": "C4236100", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to D-galactosamine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12057922]"}
{"concept_id": "C4236101", "aliases": [], "types": ["T043"], "canonical_name": "response to D-galactosamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12057922]"}
{"concept_id": "C4236102", "aliases": ["upregulation of t-loop formation", "up regulation of t-loop biosynthesis", "upregulation of t-loop biosynthesis", "positive regulation of t-loop formation", "up-regulation of t-loop biosynthesis", "up-regulation of t-loop formation", "up regulation of telomeric loop formation", "up regulation of t-loop formation", "up-regulation of telomeric loop formation", "upregulation of telomeric loop formation", "positive regulation of t-loop biosynthesis"], "types": ["T045"], "canonical_name": "positive regulation of telomeric loop formation", "definition": "Any process that activates or increases the frequency, rate or extent of telomeric loop formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4236103", "aliases": ["down regulation of t-loop biosynthesis", "down regulation of t-loop formation", "down-regulation of t-loop biosynthesis", "negative regulation of t-loop biosynthesis", "negative regulation of t-loop formation", "down regulation of telomeric loop formation", "down-regulation of t-loop formation", "downregulation of t-loop biosynthesis", "down-regulation of telomeric loop formation", "downregulation of telomeric loop formation", "downregulation of t-loop formation"], "types": ["T045"], "canonical_name": "negative regulation of telomeric loop formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4236104", "aliases": ["regulation of t-loop biosynthesis", "regulation of t-loop formation"], "types": ["T045"], "canonical_name": "regulation of telomeric loop formation", "definition": "Any process that modulates the frequency, rate or extent of telomeric loop formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]"}
{"concept_id": "C4236105", "aliases": ["upregulation of xenophagy", "up-regulation of xenophagy", "up regulation of xenophagy"], "types": ["T043"], "canonical_name": "positive regulation of xenophagy", "definition": "Any process that activates or increases the frequency, rate or extent of xenophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]"}
{"concept_id": "C4236106", "aliases": ["down regulation of xenophagy", "down-regulation of xenophagy", "downregulation of xenophagy"], "types": ["T043"], "canonical_name": "negative regulation of xenophagy", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of xenophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]"}
{"concept_id": "C4236107", "aliases": [], "types": ["T043"], "canonical_name": "regulation of xenophagy", "definition": "Any process that modulates the frequency, rate or extent of xenophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]"}
{"concept_id": "C4236108", "aliases": ["up regulation of cardiac ventricle development", "up-regulation of cardiac ventricle development", "upregulation of cardiac ventricle development"], "types": ["T042"], "canonical_name": "positive regulation of cardiac ventricle development", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. [GO_REF:0000058, GOC:TermGenie, PMID:19590510]"}
{"concept_id": "C4236109", "aliases": ["down-regulation of cardiac ventricle development", "down regulation of cardiac ventricle development", "downregulation of cardiac ventricle development"], "types": ["T042"], "canonical_name": "negative regulation of cardiac ventricle development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. [GO_REF:0000058, GOC:TermGenie, PMID:19590510]"}
{"concept_id": "C4236110", "aliases": [], "types": ["T042"], "canonical_name": "regulation of cardiac ventricle development", "definition": "Any process that modulates the frequency, rate or extent of cardiac ventricle development. [GO_REF:0000058, GOC:TermGenie, PMID:19590510]"}
{"concept_id": "C4236111", "aliases": ["upregulation of secretory granule organization", "up regulation of secretory granule organisation", "up regulation of secretory granule organization", "up-regulation of secretory granule organization", "positive regulation of secretory granule organisation", "upregulation of secretory granule organisation", "up-regulation of secretory granule organisation"], "types": ["T043"], "canonical_name": "positive regulation of secretory granule organization", "definition": "Any process that activates or increases the frequency, rate or extent of secretory granule organization. [GO_REF:0000058, GOC:TermGenie, PMID:15039777]"}
{"concept_id": "C4236112", "aliases": ["down-regulation of secretory granule organization", "downregulation of secretory granule organisation", "negative regulation of secretory granule organisation", "down regulation of secretory granule organisation", "down-regulation of secretory granule organisation", "downregulation of secretory granule organization", "down regulation of secretory granule organization"], "types": ["T043"], "canonical_name": "negative regulation of secretory granule organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization. [GO_REF:0000058, GOC:TermGenie, PMID:15039777]"}
{"concept_id": "C4236113", "aliases": ["regulation of secretory granule organisation"], "types": ["T043"], "canonical_name": "regulation of secretory granule organization", "definition": "Any process that modulates the frequency, rate or extent of secretory granule organization. [GO_REF:0000058, GOC:TermGenie, PMID:15039777]"}
{"concept_id": "C4236114", "aliases": [], "types": ["T044"], "canonical_name": "melatonin binding", "definition": "Binding to melatonin. [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923]"}
{"concept_id": "C4236115", "aliases": ["up regulation of nitric oxide metabolic process", "upregulation of nitric oxide metabolism", "up-regulation of nitric oxide metabolism", "up-regulation of nitric oxide metabolic process", "up regulation of nitric oxide metabolism", "positive regulation of nitric oxide metabolism", "upregulation of nitric oxide metabolic process"], "types": ["T044"], "canonical_name": "positive regulation of nitric oxide metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of nitric oxide metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:11991626]"}
{"concept_id": "C4236116", "aliases": ["down-regulation of nitric oxide metabolic process", "down regulation of nitric oxide metabolic process", "downregulation of nitric oxide metabolic process", "downregulation of nitric oxide metabolism", "negative regulation of nitric oxide metabolism", "down regulation of nitric oxide metabolism", "down-regulation of nitric oxide metabolism"], "types": ["T044"], "canonical_name": "negative regulation of nitric oxide metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:11991626]"}
{"concept_id": "C4236117", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to formaldehyde", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:9149109]"}
{"concept_id": "C4236118", "aliases": [], "types": ["T039"], "canonical_name": "response to formaldehyde", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:9149109]"}
{"concept_id": "C4236119", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nocodazole", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17822405]"}
{"concept_id": "C4236120", "aliases": [], "types": ["T043"], "canonical_name": "response to nocodazole", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17822405]"}
{"concept_id": "C4236121", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to Thyroid stimulating hormone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:11238928]"}
{"concept_id": "C4236122", "aliases": [], "types": ["T039"], "canonical_name": "response to Thyroid stimulating hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:11238928]"}
{"concept_id": "C4236123", "aliases": ["positive regulation of neuromuscular junction organization"], "types": ["T044"], "canonical_name": "positive regulation of neuromuscular junction development", "definition": "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. [GO_REF:0000058, GOC:TermGenie, PMID:7722643]"}
{"concept_id": "C4236124", "aliases": ["regulation of neuromuscular junction organization"], "types": ["T042"], "canonical_name": "regulation of neuromuscular junction development", "definition": "Any process that modulates the frequency, rate or extent of neuromuscular junction development. [GO_REF:0000058, GOC:TermGenie, PMID:7722643]"}
{"concept_id": "C4236125", "aliases": ["up regulation of skeletal muscle acetylcholine-gated channel clustering", "upregulation of skeletal muscle acetylcholine-gated channel clustering", "up regulation of skeletal muscle AChR clustering", "up-regulation of skeletal muscle AChR clustering", "upregulation of skeletal muscle nicotinic acetylcholine receptor clustering", "positive regulation of skeletal muscle nicotinic acetylcholine receptor clustering", "upregulation of skeletal muscle AChR clustering", "positive regulation of skeletal muscle AChR clustering", "up regulation of skeletal muscle nicotinic acetylcholine receptor clustering", "up-regulation of skeletal muscle nicotinic acetylcholine receptor clustering", "up-regulation of skeletal muscle acetylcholine-gated channel clustering"], "types": ["T043"], "canonical_name": "positive regulation of skeletal muscle acetylcholine-gated channel clustering", "definition": "Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering. [GO_REF:0000058, GOC:TermGenie, PMID:7722643]"}
{"concept_id": "C4236126", "aliases": ["down-regulation of skeletal muscle acetylcholine-gated channel clustering", "downregulation of skeletal muscle AChR clustering", "down-regulation of skeletal muscle nicotinic acetylcholine receptor clustering", "down-regulation of skeletal muscle AChR clustering", "negative regulation of skeletal muscle nicotinic acetylcholine receptor clustering", "down regulation of skeletal muscle acetylcholine-gated channel clustering", "downregulation of skeletal muscle nicotinic acetylcholine receptor clustering", "down regulation of skeletal muscle AChR clustering", "negative regulation of skeletal muscle AChR clustering", "down regulation of skeletal muscle nicotinic acetylcholine receptor clustering", "downregulation of skeletal muscle acetylcholine-gated channel clustering"], "types": ["T043"], "canonical_name": "negative regulation of skeletal muscle acetylcholine-gated channel clustering", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering. [GO_REF:0000058, GOC:TermGenie, PMID:7722643]"}
{"concept_id": "C4236127", "aliases": ["regulation of skeletal muscle nicotinic acetylcholine receptor clustering", "regulation of skeletal muscle AChR clustering"], "types": ["T043"], "canonical_name": "regulation of skeletal muscle acetylcholine-gated channel clustering", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering. [GO_REF:0000058, GOC:TermGenie, PMID:7722643]"}
{"concept_id": "C4236128", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to ciliary neurotrophic factor", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16914133]"}
{"concept_id": "C4236129", "aliases": [], "types": ["T043"], "canonical_name": "response to ciliary neurotrophic factor", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16914133]"}
{"concept_id": "C4236130", "aliases": ["retinal cone bipolar cell differentiation", "cone bipolar cell differentiation"], "types": ["T043"], "canonical_name": "cone retinal bipolar cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a cone retinal bipolar cell. [GO_REF:0000086, GOC:TermGenie, PMID:24123365]"}
{"concept_id": "C4236131", "aliases": [], "types": ["T043"], "canonical_name": "rod bipolar cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a rod bipolar cell. [GO_REF:0000086, GOC:TermGenie, PMID:16914133]"}
{"concept_id": "C4236132", "aliases": ["downregulation of ncRNA transcription associated with protein coding gene TSS/TES", "down-regulation of ncRNA transcription associated with protein coding gene TSS/TES", "down regulation of ncRNA transcription associated with protein coding gene TSS/TES"], "types": ["T045"], "canonical_name": "negative regulation of ncRNA transcription associated with protein coding gene TSS/TES", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ncRNA transcription associated with protein coding gene TSS/TES. [GO_REF:0000058, GOC:TermGenie, PMID:20502517]"}
{"concept_id": "C4236133", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to L-phenylalanine derivative", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12112407]"}
{"concept_id": "C4236134", "aliases": [], "types": ["T043"], "canonical_name": "response to L-phenylalanine derivative", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12112407]"}
{"concept_id": "C4236135", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to angiotensin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. [GO_REF:0000071, GOC:TermGenie, PMID:22982863]"}
{"concept_id": "C4236136", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to sodium phosphate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24625659]"}
{"concept_id": "C4236137", "aliases": [], "types": ["T043"], "canonical_name": "response to sodium phosphate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24625659]"}
{"concept_id": "C4236138", "aliases": ["protein alpha-1,2-demannosylation involved in ER-associated glycoprotein degradation", "protein alpha-1,2-demannosylation involved in glycoprotein ERAD", "protein alpha-1,2-demannosylation involved in gpERAD", "protein alpha-1,2-demannosylation involved in glycoprotein ERAD pathway"], "types": ["T044"], "canonical_name": "mannose trimming involved in glycoprotein ERAD pathway", "definition": "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD). [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]"}
{"concept_id": "C4236139", "aliases": ["protein alpha-1,2-demannosylation in Golgi complex", "mannose trimming in Golgi apparatus", "protein alpha-1,2-demannosylation in Golgi apparatus"], "types": ["T044"], "canonical_name": "Golgi apparatus mannose trimming", "definition": "Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus. [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:10915796]"}
{"concept_id": "C4236140", "aliases": ["ER protein alpha-1,2-demannosylation", "protein alpha-1,2-demannosylation in endoplasmic reticulum", "protein alpha-1,2-demannosylation in endoplasmic reticulum quality control compartment", "protein alpha-1,2-demannosylation in ERQC", "protein alpha-1,2-demannosylation in ER", "protein alpha-1,2-demannosylation in ER quality control compartment", "ER mannose trimming"], "types": ["T044"], "canonical_name": "endoplasmic reticulum mannose trimming", "definition": "Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC). [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]"}
{"concept_id": "C4236141", "aliases": ["up regulation of protein localization to cell periphery", "up-regulation of protein localization to cell periphery", "upregulation of protein localization to cell periphery"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to cell periphery", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. [GO_REF:0000058, GOC:TermGenie, PMID:18216290]"}
{"concept_id": "C4236142", "aliases": ["down regulation of protein localization to cell periphery", "downregulation of protein localization to cell periphery", "down-regulation of protein localization to cell periphery"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to cell periphery", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. [GO_REF:0000058, GOC:TermGenie, PMID:18216290]"}
{"concept_id": "C4236143", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein localization to cell periphery", "definition": "Any process that modulates the frequency, rate or extent of protein localization to cell periphery. [GO_REF:0000058, GOC:TermGenie, PMID:18216290]"}
{"concept_id": "C4236144", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to kainic acid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17443789]"}
{"concept_id": "C4236145", "aliases": [], "types": ["T043"], "canonical_name": "response to kainic acid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17443789]"}
{"concept_id": "C4236146", "aliases": ["up regulation of protein localisation to actin cortical patch", "up regulation of protein localization to actin cortical patch", "positive regulation of protein localisation to actin cortical patch", "up-regulation of protein localization to actin cortical patch", "up-regulation of protein localisation to actin cortical patch", "upregulation of protein localisation to actin cortical patch", "upregulation of protein localization to actin cortical patch"], "types": ["T039"], "canonical_name": "positive regulation of protein localization to actin cortical patch", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to actin cortical patch. [GO_REF:0000058, GOC:TermGenie, PMID:18216290]"}
{"concept_id": "C4236147", "aliases": ["down-regulation of protein localisation to actin cortical patch", "downregulation of protein localization to actin cortical patch", "downregulation of protein localisation to actin cortical patch", "down regulation of protein localisation to actin cortical patch", "negative regulation of protein localisation to actin cortical patch", "down-regulation of protein localization to actin cortical patch", "down regulation of protein localization to actin cortical patch"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to actin cortical patch", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to actin cortical patch. [GO_REF:0000058, GOC:TermGenie, PMID:18216290]"}
{"concept_id": "C4236148", "aliases": ["regulation of protein localisation to actin cortical patch"], "types": ["T043"], "canonical_name": "regulation of protein localization to actin cortical patch", "definition": "Any process that modulates the frequency, rate or extent of protein localization to actin cortical patch. [GO_REF:0000058, GOC:TermGenie, PMID:18216290]"}
{"concept_id": "C4236149", "aliases": ["up-regulation of sclerenchyma cell differentiation", "up regulation of sclerenchyma cell differentiation", "upregulation of sclerenchyma cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of sclerenchyma cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of sclerenchyma cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:26025534]"}
{"concept_id": "C4236150", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sclerenchyma cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of sclerenchyma cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:26025534]"}
{"concept_id": "C4236151", "aliases": ["up regulation of chemokinesis", "up-regulation of chemokinesis", "upregulation of chemokinesis"], "types": ["T039"], "canonical_name": "positive regulation of chemokinesis", "definition": "Any process that activates or increases the frequency, rate or extent of chemokinesis. [GO_REF:0000058, GOC:TermGenie, PMID:8679543]"}
{"concept_id": "C4236152", "aliases": ["down regulation of chemokinesis", "downregulation of chemokinesis", "down-regulation of chemokinesis"], "types": ["T043"], "canonical_name": "negative regulation of chemokinesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chemokinesis. [GO_REF:0000058, GOC:TermGenie, PMID:8679543]"}
{"concept_id": "C4236153", "aliases": [], "types": ["T039"], "canonical_name": "regulation of chemokinesis", "definition": "Any process that modulates the frequency, rate or extent of chemokinesis. [GO_REF:0000058, GOC:TermGenie, PMID:8679543]"}
{"concept_id": "C4236154", "aliases": ["upregulation of calcitonin secretion", "up regulation of calcitonin secretion", "up-regulation of calcitonin secretion"], "types": ["T043"], "canonical_name": "positive regulation of calcitonin secretion", "definition": "Any process that activates or increases the frequency, rate or extent of calcitonin secretion. [GO_REF:0000058, GOC:TermGenie, PMID:11278900]"}
{"concept_id": "C4236155", "aliases": ["downregulation of calcitonin secretion", "down regulation of calcitonin secretion", "down-regulation of calcitonin secretion"], "types": ["T043"], "canonical_name": "negative regulation of calcitonin secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion. [GO_REF:0000058, GOC:TermGenie, PMID:11278900]"}
{"concept_id": "C4236156", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcitonin secretion", "definition": "Any process that modulates the frequency, rate or extent of calcitonin secretion. [GO_REF:0000058, GOC:TermGenie, PMID:11278900]"}
{"concept_id": "C4236157", "aliases": ["up regulation of spore germination", "upregulation of spore germination", "up-regulation of spore germination"], "types": ["T039"], "canonical_name": "positive regulation of spore germination", "definition": "Any process that activates or increases the frequency, rate or extent of spore germination. [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]"}
{"concept_id": "C4236158", "aliases": ["down regulation of spore germination", "downregulation of spore germination", "down-regulation of spore germination"], "types": ["T039"], "canonical_name": "negative regulation of spore germination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of spore germination. [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]"}
{"concept_id": "C4236159", "aliases": [], "types": ["T044"], "canonical_name": "regulation of spore germination", "definition": "Any process that modulates the frequency, rate or extent of spore germination. [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]"}
{"concept_id": "C4236160", "aliases": ["up-regulation of telomere maintenance via telomere lengthening", "upregulation of telomere maintenance via telomere lengthening", "up regulation of telomere maintenance via telomere lengthening"], "types": ["T045"], "canonical_name": "positive regulation of telomere maintenance via telomere lengthening", "definition": "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]"}
{"concept_id": "C4236161", "aliases": ["down regulation of telomere maintenance via telomere lengthening", "down-regulation of telomere maintenance via telomere lengthening", "downregulation of telomere maintenance via telomere lengthening"], "types": ["T045"], "canonical_name": "negative regulation of telomere maintenance via telomere lengthening", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]"}
{"concept_id": "C4236162", "aliases": [], "types": ["T045"], "canonical_name": "regulation of telomere maintenance via telomere lengthening", "definition": "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]"}
{"concept_id": "C4236163", "aliases": ["up regulation of telomere end protection", "positive regulation of telomere end protection", "upregulation of telomere capping", "up regulation of telomere capping", "up-regulation of telomere end protection", "up-regulation of telomere capping", "upregulation of telomere end protection"], "types": ["T045"], "canonical_name": "positive regulation of telomere capping", "definition": "Any process that activates or increases the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]"}
{"concept_id": "C4236164", "aliases": ["downregulation of telomere end protection", "down-regulation of telomere end protection", "negative regulation of telomere end protection", "down regulation of telomere end protection", "down-regulation of telomere capping", "down regulation of telomere capping", "downregulation of telomere capping"], "types": ["T045"], "canonical_name": "negative regulation of telomere capping", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]"}
{"concept_id": "C4236165", "aliases": ["regulation of telomere end protection"], "types": ["T045"], "canonical_name": "regulation of telomere capping", "definition": "Any process that modulates the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]"}
{"concept_id": "C4236166", "aliases": ["up-regulation of protein catabolic process in the vacuole", "up regulation of protein catabolic process in the vacuole", "upregulation of protein catabolic process in the vacuole"], "types": ["T044"], "canonical_name": "positive regulation of protein catabolic process in the vacuole", "definition": "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]"}
{"concept_id": "C4236167", "aliases": ["downregulation of protein catabolic process in the vacuole", "down-regulation of protein catabolic process in the vacuole", "down regulation of protein catabolic process in the vacuole"], "types": ["T044"], "canonical_name": "negative regulation of protein catabolic process in the vacuole", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]"}
{"concept_id": "C4236168", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein catabolic process in the vacuole", "definition": "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]"}
{"concept_id": "C4236169", "aliases": ["up-regulation of small intestine smooth muscle contraction", "upregulation of small intestine smooth muscle contraction", "up regulation of small intestine smooth muscle contraction"], "types": ["T042"], "canonical_name": "positive regulation of small intestine smooth muscle contraction", "definition": "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:11991626]"}
{"concept_id": "C4236170", "aliases": ["down regulation of small intestine smooth muscle contraction", "down-regulation of small intestine smooth muscle contraction", "downregulation of small intestine smooth muscle contraction"], "types": ["T042"], "canonical_name": "negative regulation of small intestine smooth muscle contraction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:11991626]"}
{"concept_id": "C4236171", "aliases": [], "types": ["T042"], "canonical_name": "regulation of small intestine smooth muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:11991626]"}
{"concept_id": "C4236172", "aliases": ["upregulation of stomach mucosal blood circulation", "up-regulation of gastric mucosal blood circulation", "up regulation of gastric mucosal blood circulation", "up regulation of stomach mucosal blood circulation", "up-regulation of stomach mucosal blood circulation", "positive regulation of stomach mucosal blood circulation", "upregulation of gastric mucosal blood circulation"], "types": ["T039"], "canonical_name": "positive regulation of gastric mucosal blood circulation", "definition": "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation. [GO_REF:0000058, GOC:TermGenie, PMID:10807413]"}
{"concept_id": "C4236173", "aliases": ["negative regulation of stomach mucosal blood circulation", "down regulation of stomach mucosal blood circulation", "downregulation of gastric mucosal blood circulation", "down-regulation of gastric mucosal blood circulation", "down-regulation of stomach mucosal blood circulation", "downregulation of stomach mucosal blood circulation", "down regulation of gastric mucosal blood circulation"], "types": ["T039"], "canonical_name": "negative regulation of gastric mucosal blood circulation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation. [GO_REF:0000058, GOC:TermGenie, PMID:10807413]"}
{"concept_id": "C4236174", "aliases": ["regulation of stomach mucosal blood circulation"], "types": ["T039"], "canonical_name": "regulation of gastric mucosal blood circulation", "definition": "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. [GO_REF:0000058, GOC:TermGenie, PMID:10807413]"}
{"concept_id": "C4236175", "aliases": ["up-regulation of colon smooth muscle contraction", "up regulation of colon smooth muscle contraction", "upregulation of colon smooth muscle contraction"], "types": ["T042"], "canonical_name": "positive regulation of colon smooth muscle contraction", "definition": "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:24170253]"}
{"concept_id": "C4236176", "aliases": ["down regulation of colon smooth muscle contraction", "down-regulation of colon smooth muscle contraction", "downregulation of colon smooth muscle contraction"], "types": ["T040"], "canonical_name": "negative regulation of colon smooth muscle contraction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:24170253]"}
{"concept_id": "C4236177", "aliases": [], "types": ["T042"], "canonical_name": "regulation of colon smooth muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:24170253]"}
{"concept_id": "C4236178", "aliases": ["up regulation of dopaminergic neuron differentiation", "up-regulation of dopaminergic neuron differentiation", "upregulation of dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "positive regulation of dopaminergic neuron differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:15522889]"}
{"concept_id": "C4236179", "aliases": ["down-regulation of dopaminergic neuron differentiation", "down regulation of dopaminergic neuron differentiation", "downregulation of dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "negative regulation of dopaminergic neuron differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:15522889]"}
{"concept_id": "C4236180", "aliases": [], "types": ["T043"], "canonical_name": "regulation of dopaminergic neuron differentiation", "definition": "Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:15522889]"}
{"concept_id": "C4236181", "aliases": ["up regulation of ductus arteriosus closure", "upregulation of ductus arteriosus closure", "up-regulation of ductus arteriosus closure"], "types": ["T042"], "canonical_name": "positive regulation of ductus arteriosus closure", "definition": "Any process that activates or increases the frequency, rate or extent of ductus arteriosus closure. [GO_REF:0000058, GOC:TermGenie, PMID:16303610]"}
{"concept_id": "C4236182", "aliases": ["down-regulation of ductus arteriosus closure", "downregulation of ductus arteriosus closure", "down regulation of ductus arteriosus closure"], "types": ["T042"], "canonical_name": "negative regulation of ductus arteriosus closure", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ductus arteriosus closure. [GO_REF:0000058, GOC:TermGenie, PMID:16303610]"}
{"concept_id": "C4236183", "aliases": [], "types": ["T042"], "canonical_name": "regulation of ductus arteriosus closure", "definition": "Any process that modulates the frequency, rate or extent of ductus arteriosus closure. [GO_REF:0000058, GOC:TermGenie, PMID:16303610]"}
{"concept_id": "C4236184", "aliases": [], "types": ["T043"], "canonical_name": "heme import across plasma membrane", "definition": "The directed movement of heme from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:25733668]"}
{"concept_id": "C4236185", "aliases": ["up-regulation of mutagenic PRR", "positive regulation of mutagenic PRR", "upregulation of error-prone translesion synthesis", "up-regulation of error-prone translesion synthesis", "up regulation of mutagenic PRR", "up regulation of error-prone translesion synthesis", "upregulation of mutagenic PRR"], "types": ["T045"], "canonical_name": "positive regulation of error-prone translesion synthesis", "definition": "Any process that activates or increases the frequency, rate or extent of error-prone translesion synthesis. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]"}
{"concept_id": "C4236186", "aliases": ["down-regulation of error-prone translesion synthesis", "down-regulation of mutagenic PRR", "downregulation of error-prone translesion synthesis", "downregulation of mutagenic PRR", "negative regulation of mutagenic PRR", "down regulation of error-prone translesion synthesis", "down regulation of mutagenic PRR"], "types": ["T045"], "canonical_name": "negative regulation of error-prone translesion synthesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of error-prone translesion synthesis. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]"}
{"concept_id": "C4236187", "aliases": ["regulation of mutagenic PRR"], "types": ["T043"], "canonical_name": "regulation of error-prone translesion synthesis", "definition": "Any process that modulates the frequency, rate or extent of error-prone translesion synthesis. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]"}
{"concept_id": "C4236188", "aliases": ["up-regulation of MFB contraction", "up regulation of MF contraction", "up-regulation of MF contraction", "up regulation of myofibroblast contraction", "up regulation of MFB contraction", "positive regulation of MF contraction", "upregulation of MFB contraction", "up-regulation of myofibroblast contraction", "upregulation of myofibroblast contraction", "upregulation of MF contraction", "positive regulation of MFB contraction"], "types": ["T043"], "canonical_name": "positive regulation of myofibroblast contraction", "definition": "Any process that activates or increases the frequency, rate or extent of myofibroblast contraction. [GO_REF:0000058, GOC:TermGenie, PMID:19239477]"}
{"concept_id": "C4236189", "aliases": ["down-regulation of MF contraction", "downregulation of MFB contraction", "downregulation of MF contraction", "downregulation of myofibroblast contraction", "negative regulation of MF contraction", "down regulation of myofibroblast contraction", "negative regulation of MFB contraction", "down regulation of MF contraction", "down-regulation of myofibroblast contraction", "down-regulation of MFB contraction", "down regulation of MFB contraction"], "types": ["T043"], "canonical_name": "negative regulation of myofibroblast contraction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast contraction. [GO_REF:0000058, GOC:TermGenie, PMID:19239477]"}
{"concept_id": "C4236190", "aliases": ["regulation of MF contraction", "regulation of MFB contraction"], "types": ["T043"], "canonical_name": "regulation of myofibroblast contraction", "definition": "Any process that modulates the frequency, rate or extent of myofibroblast contraction. [GO_REF:0000058, GOC:TermGenie, PMID:19239477]"}
{"concept_id": "C4236191", "aliases": ["protein localization in cytosolic proteasome complex", "protein localisation in cytosolic proteasome complex", "protein localisation to cytosolic proteasome complex"], "types": ["T043"], "canonical_name": "protein localization to cytosolic proteasome complex", "definition": "A process in which a protein is transported to, or maintained in, a location within a cytosolic proteasome complex. [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]"}
{"concept_id": "C4236192", "aliases": ["downregulation of circadian sleep/wake cycle, wakefulness", "down regulation of circadian sleep/wake cycle, wakefulness", "down-regulation of circadian sleep/wake cycle, wakefulness"], "types": ["T040"], "canonical_name": "negative regulation of circadian sleep/wake cycle, wakefulness", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of circadian sleep/wake cycle, wakefulness. [GO_REF:0000058, GOC:TermGenie, PMID:10923657]"}
{"concept_id": "C4236193", "aliases": ["up-regulation of inhibitory G-protein coupled receptor phosphorylation", "positive regulation of inhibitory G-protein coupled receptor phosphorylation", "up regulation of inhibitory G-protein coupled receptor phosphorylation", "upregulation of inhibitory G-protein coupled receptor phosphorylation"], "types": ["T044"], "canonical_name": "positive regulation of inhibitory G protein-coupled receptor phosphorylation", "definition": "Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation. [GO_REF:0000058, GOC:TermGenie, PMID:15937517]"}
{"concept_id": "C4236194", "aliases": ["negative regulation of inhibitory G-protein coupled receptor phosphorylation", "downregulation of inhibitory G-protein coupled receptor phosphorylation", "down-regulation of inhibitory G-protein coupled receptor phosphorylation", "down regulation of inhibitory G-protein coupled receptor phosphorylation"], "types": ["T044"], "canonical_name": "negative regulation of inhibitory G protein-coupled receptor phosphorylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation. [GO_REF:0000058, GOC:TermGenie, PMID:15937517]"}
{"concept_id": "C4236195", "aliases": ["regulation of inhibitory G-protein coupled receptor phosphorylation"], "types": ["T044"], "canonical_name": "regulation of inhibitory G protein-coupled receptor phosphorylation", "definition": "Any process that modulates the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation. [GO_REF:0000058, GOC:TermGenie, PMID:15937517]"}
{"concept_id": "C4236196", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to forskolin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:15937517]"}
{"concept_id": "C4236197", "aliases": [], "types": ["T043"], "canonical_name": "response to forskolin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:15937517]"}
{"concept_id": "C4236198", "aliases": ["up-regulation of smooth muscle contraction involved in micturition", "upregulation of smooth muscle contraction involved in micturition", "up regulation of smooth muscle contraction involved in micturition"], "types": ["T042"], "canonical_name": "positive regulation of smooth muscle contraction involved in micturition", "definition": "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition. [GO_REF:0000058, GOC:TermGenie, PMID:18562635]"}
{"concept_id": "C4236199", "aliases": ["down regulation of smooth muscle contraction involved in micturition", "downregulation of smooth muscle contraction involved in micturition", "down-regulation of smooth muscle contraction involved in micturition"], "types": ["T042"], "canonical_name": "negative regulation of smooth muscle contraction involved in micturition", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition. [GO_REF:0000058, GOC:TermGenie, PMID:18562635]"}
{"concept_id": "C4236200", "aliases": [], "types": ["T042"], "canonical_name": "regulation of smooth muscle contraction involved in micturition", "definition": "Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition. [GO_REF:0000058, GOC:TermGenie, PMID:18562635]"}
{"concept_id": "C4236201", "aliases": [], "types": ["T044"], "canonical_name": "transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential", "definition": "Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. [GO_REF:0000061, GOC:TermGenie, PMID:20200227]"}
{"concept_id": "C4236202", "aliases": ["cellular response to methamphetamine HCL"], "types": ["T043"], "canonical_name": "cellular response to methamphetamine hydrochloride", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22174933]"}
{"concept_id": "C4236203", "aliases": ["response to methamphetamine HCL"], "types": ["T043"], "canonical_name": "response to methamphetamine hydrochloride", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22174933]"}
{"concept_id": "C4236204", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to gold(3+)", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16206274]"}
{"concept_id": "C4236205", "aliases": [], "types": ["T043"], "canonical_name": "response to gold(3+)", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16206274]"}
{"concept_id": "C4236206", "aliases": ["cellular response to 3'-deoxyadenosine"], "types": ["T043"], "canonical_name": "cellular response to cordycepin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21597460]"}
{"concept_id": "C4236207", "aliases": ["response to 3'-deoxyadenosine"], "types": ["T043"], "canonical_name": "response to cordycepin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21597460]"}
{"concept_id": "C4236208", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to desipramine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20549303]"}
{"concept_id": "C4236209", "aliases": [], "types": ["T043"], "canonical_name": "response to desipramine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:20549303]"}
{"concept_id": "C4236210", "aliases": ["upregulation of gastro-intestinal system smooth muscle contraction", "up-regulation of gastro-intestinal system smooth muscle contraction", "up regulation of gastro-intestinal system smooth muscle contraction"], "types": ["T042"], "canonical_name": "positive regulation of gastro-intestinal system smooth muscle contraction", "definition": "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:10821044]"}
{"concept_id": "C4236211", "aliases": ["downregulation of gastro-intestinal system smooth muscle contraction", "down regulation of gastro-intestinal system smooth muscle contraction", "down-regulation of gastro-intestinal system smooth muscle contraction"], "types": ["T042"], "canonical_name": "negative regulation of gastro-intestinal system smooth muscle contraction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:10821044]"}
{"concept_id": "C4236212", "aliases": [], "types": ["T042"], "canonical_name": "regulation of gastro-intestinal system smooth muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:10821044]"}
{"concept_id": "C4236213", "aliases": ["upregulation of maternal process involved in parturition", "up-regulation of maternal process involved in parturition", "up regulation of maternal process involved in parturition"], "types": ["T038"], "canonical_name": "positive regulation of maternal process involved in parturition", "definition": "Any process that activates or increases the frequency, rate or extent of maternal process involved in parturition. [GO_REF:0000058, GOC:TermGenie, PMID:1849751]"}
{"concept_id": "C4236214", "aliases": ["down regulation of maternal process involved in parturition", "down-regulation of maternal process involved in parturition", "downregulation of maternal process involved in parturition"], "types": ["T038"], "canonical_name": "negative regulation of maternal process involved in parturition", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of maternal process involved in parturition. [GO_REF:0000058, GOC:TermGenie, PMID:1849751]"}
{"concept_id": "C4236215", "aliases": [], "types": ["T039"], "canonical_name": "regulation of maternal process involved in parturition", "definition": "Any process that modulates the frequency, rate or extent of maternal process involved in parturition. [GO_REF:0000058, GOC:TermGenie, PMID:1849751]"}
{"concept_id": "C4236216", "aliases": ["up regulation of transcytosis", "upregulation of transcytosis", "up-regulation of transcytosis"], "types": ["T043"], "canonical_name": "positive regulation of transcytosis", "definition": "Any process that activates or increases the frequency, rate or extent of transcytosis. [GO_REF:0000058, GOC:TermGenie, PMID:9664076]"}
{"concept_id": "C4236217", "aliases": ["down regulation of transcytosis", "downregulation of transcytosis", "down-regulation of transcytosis"], "types": ["T043"], "canonical_name": "negative regulation of transcytosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transcytosis. [GO_REF:0000058, GOC:TermGenie, PMID:9664076]"}
{"concept_id": "C4236218", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transcytosis", "definition": "Any process that modulates the frequency, rate or extent of transcytosis. [GO_REF:0000058, GOC:TermGenie, PMID:9664076]"}
{"concept_id": "C4236219", "aliases": ["up regulation of osmolarity-sensing cation channel activity", "up-regulation of osmolarity-sensing cation channel activity", "upregulation of osmolarity-sensing cation channel activity"], "types": ["T044"], "canonical_name": "positive regulation of osmolarity-sensing cation channel activity", "definition": "Any process that activates or increases the frequency, rate or extent of osmolarity-sensing cation channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:18279313]"}
{"concept_id": "C4236220", "aliases": ["downregulation of osmolarity-sensing cation channel activity", "down-regulation of osmolarity-sensing cation channel activity", "down regulation of osmolarity-sensing cation channel activity"], "types": ["T044"], "canonical_name": "negative regulation of osmolarity-sensing cation channel activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of osmolarity-sensing cation channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:18279313]"}
{"concept_id": "C4236221", "aliases": [], "types": ["T039"], "canonical_name": "regulation of osmolarity-sensing cation channel activity", "definition": "Any process that modulates the frequency, rate or extent of osmolarity-sensing cation channel activity. [GO_REF:0000059, GOC:TermGenie, PMID:18279313]"}
{"concept_id": "C4236222", "aliases": ["downregulation of ERAD pathway", "down regulation of endoplasmic reticulum-associated degradation", "down regulation of ERAD pathway", "down-regulation of endoplasmic reticulum-associated degradation", "negative regulation of endoplasmic reticulum-associated degradation", "downregulation of endoplasmic reticulum-associated degradation", "down-regulation of ERAD pathway"], "types": ["T043"], "canonical_name": "negative regulation of ERAD pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22590560]"}
{"concept_id": "C4236223", "aliases": ["regulation of endoplasmic reticulum-associated degradation"], "types": ["T043"], "canonical_name": "regulation of ERAD pathway", "definition": "Any process that modulates the frequency, rate or extent of ERAD pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4236224", "aliases": ["up-regulation of mitotic DNA damage checkpoint", "upregulation of mitotic DNA damage checkpoint", "up regulation of mitotic DNA damage checkpoint"], "types": ["T045"], "canonical_name": "positive regulation of mitotic DNA damage checkpoint", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic DNA damage checkpoint. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501]"}
{"concept_id": "C4236225", "aliases": ["down regulation of mitotic DNA damage checkpoint", "downregulation of mitotic DNA damage checkpoint", "down-regulation of mitotic DNA damage checkpoint"], "types": ["T043"], "canonical_name": "negative regulation of mitotic DNA damage checkpoint", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic DNA damage checkpoint. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501]"}
{"concept_id": "C4236226", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mitotic DNA damage checkpoint", "definition": "Any process that modulates the frequency, rate or extent of mitotic DNA damage checkpoint. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501]"}
{"concept_id": "C4236227", "aliases": ["stimulation of protein-pyridoxal-5-phosphate linkage", "up-regulation of protein-pyridoxal-5-phosphate linkage", "up regulation of protein-pyridoxal-5-phosphate linkage", "upregulation of protein-pyridoxal-5-phosphate linkage"], "types": ["T044"], "canonical_name": "positive regulation of protein-pyridoxal-5-phosphate linkage", "definition": "Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage. [GO_REF:0000058, GOC:TermGenie, PMID:25957689]"}
{"concept_id": "C4236228", "aliases": ["down-regulation of protein-pyridoxal-5-phosphate linkage", "downregulation of protein-pyridoxal-5-phosphate linkage", "down regulation of protein-pyridoxal-5-phosphate linkage"], "types": ["T044"], "canonical_name": "negative regulation of protein-pyridoxal-5-phosphate linkage", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage. [GO_REF:0000058, GOC:TermGenie, PMID:25957689]"}
{"concept_id": "C4236229", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein-pyridoxal-5-phosphate linkage", "definition": "Any process that modulates the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage. [GO_REF:0000058, GOC:TermGenie, PMID:25957689]"}
{"concept_id": "C4236230", "aliases": ["up-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I", "upregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I", "up regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I", "up-regulation of endogenous peptide antigen processing and presentation via MHC class I", "upregulation of endogenous peptide antigen processing and presentation via MHC class I", "up regulation of endogenous peptide antigen processing and presentation via MHC class I", "positive regulation of endogenous peptide antigen processing and presentation via MHC class I"], "types": ["T043"], "canonical_name": "positive regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I", "definition": "Any process that activates or increases the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698]"}
{"concept_id": "C4236231", "aliases": ["down regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I", "negative regulation of endogenous peptide antigen processing and presentation via MHC class I", "down-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I", "down-regulation of endogenous peptide antigen processing and presentation via MHC class I", "down regulation of endogenous peptide antigen processing and presentation via MHC class I", "downregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I", "downregulation of endogenous peptide antigen processing and presentation via MHC class I"], "types": ["T043"], "canonical_name": "negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698]"}
{"concept_id": "C4236232", "aliases": ["regulation of endogenous peptide antigen processing and presentation via MHC class I"], "types": ["T043"], "canonical_name": "regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I", "definition": "Any process that modulates the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698]"}
{"concept_id": "C4236233", "aliases": ["up regulation of transcription from RNA polymerase V promoter", "up regulation of transcription from RNA pol V promoter", "upregulation of transcription from RNA pol V promoter", "positive regulation of transcription from RNA pol V promoter", "up-regulation of transcription from RNA pol V promoter", "positive regulation of transcription from RNA polymerase V promoter", "up-regulation of transcription from RNA polymerase V promoter", "upregulation of transcription from RNA polymerase V promoter"], "types": ["T045"], "canonical_name": "positive regulation of transcription by RNA polymerase V", "definition": "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase V. [GO_REF:0000058, GOC:TermGenie, PMID:24726328]"}
{"concept_id": "C4236234", "aliases": ["downregulation of transcription from RNA pol V promoter", "negative regulation of transcription from RNA polymerase V promoter", "down regulation of transcription from RNA polymerase V promoter", "down-regulation of transcription from RNA pol V promoter", "down-regulation of transcription from RNA polymerase V promoter", "negative regulation of transcription from RNA pol V promoter", "down regulation of transcription from RNA pol V promoter", "downregulation of transcription from RNA polymerase V promoter"], "types": ["T045"], "canonical_name": "negative regulation of transcription by RNA polymerase V", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transcription mediated by RNA polymerase V. [GO_REF:0000058, GOC:TermGenie, PMID:24726328]"}
{"concept_id": "C4236235", "aliases": ["regulation of transcription from RNA polymerase V promoter", "regulation of transcription from RNA pol V promoter"], "types": ["T045"], "canonical_name": "regulation of transcription by RNA polymerase V", "definition": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase V. [GO_REF:0000058, GOC:TermGenie, PMID:24726328]"}
{"concept_id": "C4236236", "aliases": ["up regulation of wax biosynthesis", "up regulation of wax formation", "upregulation of wax anabolism", "positive regulation of wax biosynthesis", "upregulation of wax formation", "up-regulation of wax biosynthetic process", "upregulation of wax synthesis", "positive regulation of wax anabolism", "positive regulation of wax formation", "positive regulation of wax synthesis", "up-regulation of wax biosynthesis", "up-regulation of wax anabolism", "upregulation of wax biosynthesis", "up regulation of wax synthesis", "up-regulation of wax synthesis", "up-regulation of wax formation", "upregulation of wax biosynthetic process", "up regulation of wax anabolism", "up regulation of wax biosynthetic process"], "types": ["T038"], "canonical_name": "positive regulation of wax biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of wax biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:24692420]"}
{"concept_id": "C4236237", "aliases": ["negative regulation of wax anabolism", "down-regulation of wax biosynthetic process", "negative regulation of wax synthesis", "down regulation of wax anabolism", "down-regulation of wax synthesis", "down regulation of wax biosynthetic process", "down-regulation of wax anabolism", "downregulation of wax anabolism", "downregulation of wax formation", "downregulation of wax synthesis", "down-regulation of wax formation", "downregulation of wax biosynthetic process", "downregulation of wax biosynthesis", "negative regulation of wax biosynthesis", "down-regulation of wax biosynthesis", "negative regulation of wax formation", "down regulation of wax synthesis", "down regulation of wax biosynthesis", "down regulation of wax formation"], "types": ["T044"], "canonical_name": "negative regulation of wax biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of wax biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:24692420]"}
{"concept_id": "C4236238", "aliases": ["regulation of wax synthesis", "regulation of wax anabolism", "regulation of wax biosynthesis", "regulation of wax formation"], "types": ["T043"], "canonical_name": "regulation of wax biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of wax biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:24692420]"}
{"concept_id": "C4236239", "aliases": [], "types": ["T043"], "canonical_name": "tricellular tight junction disassembly", "definition": "The disaggregation of a tricellular tight junction into its constituent components. [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962]"}
{"concept_id": "C4236240", "aliases": ["tricellular tight junction formation"], "types": ["T043"], "canonical_name": "tricellular tight junction assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a tricellular tight junction. [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962]"}
{"concept_id": "C4236241", "aliases": [], "types": ["T043"], "canonical_name": "L-alanine import across plasma membrane", "definition": "The directed import of L-alanine from the extracellular region across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500]"}
{"concept_id": "C4236242", "aliases": [], "types": ["T043"], "canonical_name": "L-tryptophan import across plasma membrane", "definition": "The directed movement of L-tryptophan from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500]"}
{"concept_id": "C4236243", "aliases": ["L-proline import into cell"], "types": ["T043"], "canonical_name": "L-proline import across plasma membrane", "definition": "The directed movement of L-proline from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500]"}
{"concept_id": "C4236244", "aliases": ["ASC pyroptosome formation", "ASC pyroptosome assembly", "pyroptosome complex formation"], "types": ["T044"], "canonical_name": "pyroptosome complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a pyroptosome complex. [GO_REF:0000079, GOC:TermGenie, PMID:17964261]"}
{"concept_id": "C4236245", "aliases": ["cell cortex of front of cell", "cell cortex of leading edge of cell", "cell cortex of cell leading edge"], "types": ["T026"], "canonical_name": "cell leading edge cell cortex", "definition": "The cell cortex of the leading edge of a cell. [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030]"}
{"concept_id": "C4236246", "aliases": ["up-regulation of Schwann cell chemotaxis", "upregulation of Schwann cell chemotaxis", "up regulation of Schwann cell chemotaxis"], "types": ["T043"], "canonical_name": "positive regulation of Schwann cell chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis. [GO_REF:0000058, GOC:TermGenie, PMID:16203995]"}
{"concept_id": "C4236247", "aliases": ["down regulation of Schwann cell chemotaxis", "down-regulation of Schwann cell chemotaxis", "downregulation of Schwann cell chemotaxis"], "types": ["T043"], "canonical_name": "negative regulation of Schwann cell chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis. [GO_REF:0000058, GOC:TermGenie, PMID:16203995]"}
{"concept_id": "C4236248", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Schwann cell chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis. [GO_REF:0000058, GOC:TermGenie, PMID:16203995]"}
{"concept_id": "C4236251", "aliases": ["up regulation of TORC1 signal transduction", "up-regulation of TORC1 signaling", "upregulation of TORC1 signaling", "up regulation of TORC1 signaling", "up-regulation of TORC1 signal transduction", "upregulation of TORC1 signal transduction", "positive regulation of TORC1 signal transduction"], "types": ["T044"], "canonical_name": "positive regulation of TORC1 signaling", "definition": "Any process that activates or increases the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275]"}
{"concept_id": "C4236252", "aliases": ["down-regulation of TORC1 signaling", "negative regulation of TORC1 signal transduction", "down regulation of TORC1 signal transduction", "down regulation of TORC1 signaling", "downregulation of TORC1 signal transduction", "downregulation of TORC1 signaling", "down-regulation of TORC1 signal transduction"], "types": ["T044"], "canonical_name": "negative regulation of TORC1 signaling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275]"}
{"concept_id": "C4236253", "aliases": ["up-regulation of basement membrane assembly involved in embryonic body morphogenesis", "upregulation of basement membrane assembly involved in embryonic body morphogenesis", "up regulation of basement membrane assembly involved in embryonic body morphogenesis"], "types": ["T043"], "canonical_name": "positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118]"}
{"concept_id": "C4236254", "aliases": ["down-regulation of basement membrane assembly involved in embryonic body morphogenesis", "downregulation of basement membrane assembly involved in embryonic body morphogenesis", "down regulation of basement membrane assembly involved in embryonic body morphogenesis"], "types": ["T043"], "canonical_name": "negative regulation of basement membrane assembly involved in embryonic body morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118]"}
{"concept_id": "C4236255", "aliases": [], "types": ["T038"], "canonical_name": "regulation of basement membrane assembly involved in embryonic body morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118]"}
{"concept_id": "C4236256", "aliases": ["D body assembly", "nuclear dicing body formation", "D body formation"], "types": ["T043"], "canonical_name": "nuclear dicing body assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a nuclear dicing body. [GO_REF:0000079, GOC:TermGenie, PMID:25902521]"}
{"concept_id": "C4236257", "aliases": ["zinc(2+) import across Golgi membrane", "cytosol to Golgi apparatus zinc transport", "zinc ion import into Golgi membrane", "zinc II ion import across Golgi membrane", "zinc ion import across Golgi membrane", "zinc ion import into Golgi apparatus"], "types": ["T043"], "canonical_name": "zinc ion import into Golgi lumen", "definition": "The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen. [GO_REF:0000075, GOC:TermGenie, PMID:25732056]"}
{"concept_id": "C4236258", "aliases": ["upregulation of iron channel activity", "up regulation of iron-specific channel activity", "positive regulation of iron channel activity", "positive regulation of iron cation channel activity", "up regulation of iron channel activity", "upregulation of iron cation channel activity", "positive regulation of iron transmembrane transporter activity", "up-regulation of iron-specific channel activity", "upregulation of iron-specific channel activity", "up-regulation of iron cation channel activity", "up regulation of iron cation channel activity", "positive regulation of iron-specific channel activity", "up-regulation of iron channel activity"], "types": ["T043"], "canonical_name": "positive regulation of iron ion transmembrane transporter activity", "definition": "Any process that activates or increases the frequency, rate or extent of an iron transmembrane transporter activity. [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]"}
{"concept_id": "C4236259", "aliases": ["down-regulation of iron channel activity", "down regulation of iron cation channel activity", "downregulation of iron cation channel activity", "downregulation of iron channel activity", "negative regulation of iron-specific channel activity", "negative regulation of iron channel activity", "down regulation of iron channel activity", "negative regulation of iron cation channel activity", "downregulation of iron-specific channel activity", "down-regulation of iron cation channel activity", "down regulation of iron-specific channel activity", "down-regulation of iron-specific channel activity"], "types": ["T043"], "canonical_name": "negative regulation of iron ion transmembrane transporter activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of an iron transmembrane transporter activity. [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]"}
{"concept_id": "C4236260", "aliases": ["regulation of iron channel activity", "regulation of iron-specific channel activity", "regulation of iron cation channel activity"], "types": ["T043"], "canonical_name": "regulation of iron ion transmembrane transporter activity", "definition": "Any process that modulates the frequency, rate or extent of an iron transmembrane transporter activity. [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]"}
{"concept_id": "C4236261", "aliases": ["up-regulation of bile acid metabolic process", "positive regulation of bile acid metabolism", "up-regulation of bile acid metabolism", "upregulation of bile acid metabolic process", "up regulation of bile acid metabolic process", "upregulation of bile acid metabolism", "up regulation of bile acid metabolism"], "types": ["T044"], "canonical_name": "positive regulation of bile acid metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. [GO_REF:0000058, GOC:bf, GOC:TermGenie]"}
{"concept_id": "C4236262", "aliases": ["negative regulation of bile acid metabolism", "down-regulation of bile acid metabolism", "down-regulation of bile acid metabolic process", "downregulation of bile acid metabolic process", "downregulation of bile acid metabolism", "down regulation of bile acid metabolic process", "down regulation of bile acid metabolism"], "types": ["T044"], "canonical_name": "negative regulation of bile acid metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. [GO_REF:0000058, GOC:bf, GOC:TermGenie]"}
{"concept_id": "C4236263", "aliases": ["regulation of bile acid metabolism"], "types": ["T044"], "canonical_name": "regulation of bile acid metabolic process", "definition": "Any process that modulates the frequency, rate or extent of bile acid metabolic process. [GO_REF:0000058, GOC:bf, GOC:TermGenie]"}
{"concept_id": "C4236264", "aliases": ["up-regulation of age-related resistance", "up-regulation of ARR", "up regulation of age-related resistance", "positive regulation of ARR", "up regulation of ARR", "upregulation of age-related resistance", "upregulation of ARR"], "types": ["T040"], "canonical_name": "positive regulation of age-related resistance", "definition": "Any process that activates or increases the extent of age-related resistance. [GO_REF:0000058, GOC:TermGenie, PMID:19694953]"}
{"concept_id": "C4236265", "aliases": ["downregulation of ARR", "negative regulation of ARR", "down regulation of ARR", "downregulation of age-related resistance", "down-regulation of age-related resistance", "down regulation of age-related resistance", "down-regulation of ARR"], "types": ["T040"], "canonical_name": "negative regulation of age-related resistance", "definition": "Any process that stops, prevents or reduces the extent of age-related resistance. [GO_REF:0000058, GOC:TermGenie, PMID:19694953]"}
{"concept_id": "C4236266", "aliases": ["regulation of ARR"], "types": ["T040"], "canonical_name": "regulation of age-related resistance", "definition": "Any process that modulates the extent of age-related resistance. [GO_REF:0000058, GOC:TermGenie, PMID:19694953]"}
{"concept_id": "C4236267", "aliases": ["up-regulation of polyadenylate nucleotidyltransferase activity", "upregulation of polyadenylate nucleotidyltransferase activity", "upregulation of poly(A) hydrolase activity", "positive regulation of ATP:polynucleotide adenylyltransferase activity", "up regulation of ATP:polynucleotide adenylyltransferase activity", "upregulation of polyadenylic polymerase activity", "up regulation of RNA adenylating enzyme activity", "up regulation of NTP polymerase activity", "upregulation of poly(A) polymerase activity", "up-regulation of RNA adenylating enzyme activity", "upregulation of ATP:polynucleotide adenylyltransferase activity", "up regulation of polyadenylate synthetase activity", "upregulation of AMP polynucleotidylexotransferase activity", "up-regulation of poly(A) synthetase activity", "up-regulation of AMP polynucleotidylexotransferase activity", "up regulation of terminal riboadenylate transferase activity", "up regulation of polyadenylic polymerase activity", "positive regulation of terminal riboadenylate transferase activity", "up regulation of AMP polynucleotidylexotransferase activity", "up regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "positive regulation of polyadenylic polymerase activity", "upregulation of ATP-polynucleotide adenylyltransferase activity", "positive regulation of polyadenylate synthetase activity", "up-regulation of ATP:polynucleotidylexotransferase activity", "upregulation of polyadenylic acid polymerase activity", "positive regulation of NTP polymerase activity", "up-regulation of poly(A) polymerase activity", "positive regulation of poly-A polymerase activity", "positive regulation of polyadenylate nucleotidyltransferase activity", "upregulation of poly(A) synthetase activity", "upregulation of polyadenylate polymerase activity", "upregulation of RNA adenylating enzyme activity", "upregulation of polyadenylate synthetase activity", "positive regulation of AMP polynucleotidylexotransferase activity", "up regulation of polyadenylate nucleotidyltransferase activity", "upregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "positive regulation of ATP:polynucleotidylexotransferase activity", "positive regulation of poly(A) polymerase activity", "up-regulation of polyadenylate synthetase activity", "up-regulation of polyadenylic polymerase activity", "up regulation of polyadenylic acid polymerase activity", "upregulation of polynucleotide adenylyltransferase activity", "up-regulation of ATP:polynucleotide adenylyltransferase activity", "up-regulation of poly-A polymerase activity", "positive regulation of polyadenylic acid polymerase activity", "up-regulation of terminal riboadenylate transferase activity", "up-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "up-regulation of ATP-polynucleotide adenylyltransferase activity", "up regulation of poly(A) hydrolase activity", "up regulation of poly(A) polymerase activity", "up-regulation of poly(A) hydrolase activity", "up regulation of polynucleotide adenylyltransferase activity", "up-regulation of polynucleotide adenylyltransferase activity", "up regulation of ATP-polynucleotide adenylyltransferase activity", "upregulation of terminal riboadenylate transferase activity", "upregulation of ATP:polynucleotidylexotransferase activity", "positive regulation of poly(A) synthetase activity", "upregulation of poly-A polymerase activity", "upregulation of NTP polymerase activity", "up regulation of poly(A) synthetase activity", "positive regulation of polyadenylate polymerase activity", "up-regulation of polyadenylic acid polymerase activity", "positive regulation of ATP-polynucleotide adenylyltransferase activity", "positive regulation of RNA adenylating enzyme activity", "up regulation of poly-A polymerase activity", "up regulation of ATP:polynucleotidylexotransferase activity", "up-regulation of NTP polymerase activity", "positive regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "positive regulation of poly(A) hydrolase activity", "up regulation of polyadenylate polymerase activity", "up-regulation of polyadenylate polymerase activity"], "types": ["T044"], "canonical_name": "positive regulation of polynucleotide adenylyltransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of polynucleotide adenylyltransferase activity. [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348]"}
{"concept_id": "C4236268", "aliases": ["down-regulation of polyadenylate polymerase activity", "down-regulation of polyadenylate synthetase activity", "downregulation of ATP:polynucleotide adenylyltransferase activity", "negative regulation of polyadenylate synthetase activity", "downregulation of ATP-polynucleotide adenylyltransferase activity", "negative regulation of AMP polynucleotidylexotransferase activity", "down regulation of ATP:polynucleotide adenylyltransferase activity", "down regulation of polyadenylate polymerase activity", "downregulation of NTP polymerase activity", "down regulation of poly(A) hydrolase activity", "downregulation of polyadenylate polymerase activity", "negative regulation of ATP:polynucleotide adenylyltransferase activity", "negative regulation of polyadenylic polymerase activity", "downregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "down-regulation of RNA adenylating enzyme activity", "down-regulation of ATP-polynucleotide adenylyltransferase activity", "negative regulation of ATP-polynucleotide adenylyltransferase activity", "down-regulation of AMP polynucleotidylexotransferase activity", "negative regulation of NTP polymerase activity", "down-regulation of poly(A) synthetase activity", "downregulation of poly-A polymerase activity", "down regulation of polyadenylate nucleotidyltransferase activity", "down-regulation of polynucleotide adenylyltransferase activity", "down regulation of ATP:polynucleotidylexotransferase activity", "down regulation of ATP-polynucleotide adenylyltransferase activity", "down regulation of RNA adenylating enzyme activity", "downregulation of AMP polynucleotidylexotransferase activity", "downregulation of terminal riboadenylate transferase activity", "downregulation of polynucleotide adenylyltransferase activity", "negative regulation of poly(A) hydrolase activity", "downregulation of polyadenylate nucleotidyltransferase activity", "downregulation of polyadenylate synthetase activity", "negative regulation of polyadenylate nucleotidyltransferase activity", "down regulation of polynucleotide adenylyltransferase activity", "down regulation of polyadenylic polymerase activity", "negative regulation of polyadenylate polymerase activity", "down regulation of AMP polynucleotidylexotransferase activity", "negative regulation of poly-A polymerase activity", "down-regulation of poly(A) hydrolase activity", "down regulation of NTP polymerase activity", "down-regulation of terminal riboadenylate transferase activity", "down-regulation of poly(A) polymerase activity", "down regulation of polyadenylate synthetase activity", "down-regulation of polyadenylate nucleotidyltransferase activity", "down-regulation of ATP:polynucleotide adenylyltransferase activity", "down-regulation of poly-A polymerase activity", "down regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "downregulation of polyadenylic acid polymerase activity", "negative regulation of RNA adenylating enzyme activity", "down regulation of poly(A) polymerase activity", "down-regulation of polyadenylic acid polymerase activity", "negative regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "negative regulation of ATP:polynucleotidylexotransferase activity", "down regulation of terminal riboadenylate transferase activity", "down regulation of polyadenylic acid polymerase activity", "negative regulation of poly(A) synthetase activity", "downregulation of poly(A) polymerase activity", "negative regulation of terminal riboadenylate transferase activity", "negative regulation of poly(A) polymerase activity", "down-regulation of polyadenylic polymerase activity", "downregulation of RNA adenylating enzyme activity", "down-regulation of ATP:polynucleotidylexotransferase activity", "downregulation of poly(A) hydrolase activity", "down regulation of poly(A) synthetase activity", "down regulation of poly-A polymerase activity", "downregulation of ATP:polynucleotidylexotransferase activity", "down-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "down-regulation of NTP polymerase activity", "negative regulation of polyadenylic acid polymerase activity", "downregulation of polyadenylic polymerase activity", "downregulation of poly(A) synthetase activity"], "types": ["T044"], "canonical_name": "negative regulation of polynucleotide adenylyltransferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of polynucleotide adenylyltransferase activity. [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348]"}
{"concept_id": "C4236269", "aliases": ["regulation of poly(A) polymerase activity", "regulation of terminal riboadenylate transferase activity", "regulation of ATP:polynucleotide adenylyltransferase activity", "regulation of polyadenylic acid polymerase activity", "regulation of poly(A) hydrolase activity", "regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "regulation of AMP polynucleotidylexotransferase activity", "regulation of NTP polymerase activity", "regulation of RNA adenylating enzyme activity", "regulation of ATP:polynucleotidylexotransferase activity", "regulation of polyadenylate synthetase activity", "regulation of polyadenylate polymerase activity", "regulation of poly-A polymerase activity", "regulation of ATP-polynucleotide adenylyltransferase activity", "regulation of polyadenylate nucleotidyltransferase activity", "regulation of polyadenylic polymerase activity", "regulation of poly(A) synthetase activity"], "types": ["T044"], "canonical_name": "regulation of polynucleotide adenylyltransferase activity", "definition": "Any process that modulates the frequency, rate or extent of polynucleotide adenylyltransferase activity. [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348]"}
{"concept_id": "C4236270", "aliases": ["upregulation of pancreatic trypsinogen secretion", "up regulation of pancreatic trypsinogen release", "up regulation of pancreatic trypsinogen secretion", "up-regulation of pancreatic trypsinogen release", "upregulation of pancreatic trypsinogen release", "up-regulation of pancreatic trypsinogen secretion", "positive regulation of pancreatic trypsinogen release"], "types": ["T043"], "canonical_name": "positive regulation of pancreatic trypsinogen secretion", "definition": "Any process that activates or increases the frequency, rate or extent of pancreatic trypsinogen secretion. [GO_REF:0000058, GOC:TermGenie, PMID:12771515]"}
{"concept_id": "C4236271", "aliases": ["down-regulation of pancreatic trypsinogen secretion", "downregulation of pancreatic trypsinogen secretion", "down regulation of pancreatic trypsinogen release", "negative regulation of pancreatic trypsinogen release", "down-regulation of pancreatic trypsinogen release", "down regulation of pancreatic trypsinogen secretion", "downregulation of pancreatic trypsinogen release"], "types": ["T043"], "canonical_name": "negative regulation of pancreatic trypsinogen secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic trypsinogen secretion. [GO_REF:0000058, GOC:TermGenie, PMID:12771515]"}
{"concept_id": "C4236272", "aliases": ["regulation of pancreatic trypsinogen release"], "types": ["T043"], "canonical_name": "regulation of pancreatic trypsinogen secretion", "definition": "Any process that modulates the frequency, rate or extent of pancreatic trypsinogen secretion. [GO_REF:0000058, GOC:TermGenie, PMID:12771515]"}
{"concept_id": "C4236273", "aliases": ["upregulation of VCP-NPL4-UFD1 AAA ATPase complex formation", "up-regulation of p97-Ufd1-Npl4 complex formation", "positive regulation of p97-Ufd1-Npl4 complex assembly", "up-regulation of p97-Ufd1-Npl4 complex assembly", "positive regulation of VCP-NPL4-UFD1 AAA ATPase complex formation", "up regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "upregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "positive regulation of p97-Ufd1-Npl4 complex formation", "upregulation of p97-Ufd1-Npl4 complex formation", "upregulation of p97-Ufd1-Npl4 complex assembly", "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation", "up regulation of p97-Ufd1-Npl4 complex formation", "up regulation of p97-Ufd1-Npl4 complex assembly", "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "up regulation of VCP-NPL4-UFD1 AAA ATPase complex formation"], "types": ["T043"], "canonical_name": "positive regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4236274", "aliases": ["down-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "down-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation", "down regulation of VCP-NPL4-UFD1 AAA ATPase complex formation", "down regulation of p97-Ufd1-Npl4 complex formation", "downregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "down regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "downregulation of p97-Ufd1-Npl4 complex formation", "down regulation of p97-Ufd1-Npl4 complex assembly", "downregulation of p97-Ufd1-Npl4 complex assembly", "down-regulation of p97-Ufd1-Npl4 complex assembly", "negative regulation of p97-Ufd1-Npl4 complex assembly", "down-regulation of p97-Ufd1-Npl4 complex formation", "negative regulation of p97-Ufd1-Npl4 complex formation", "negative regulation of VCP-NPL4-UFD1 AAA ATPase complex formation", "downregulation of VCP-NPL4-UFD1 AAA ATPase complex formation"], "types": ["T043"], "canonical_name": "negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]"}
{"concept_id": "C4236275", "aliases": ["regulation of p97-Ufd1-Npl4 complex formation", "regulation of VCP-NPL4-UFD1 AAA ATPase complex formation", "regulation of p97-Ufd1-Npl4 complex assembly"], "types": ["T043"], "canonical_name": "regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "definition": "Any process that modulates the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4236276", "aliases": [], "types": ["T043"], "canonical_name": "pericyte cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell. [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:23868830]"}
{"concept_id": "C4236277", "aliases": ["up regulation of substrate-dependent cell migration, cell attachment to substrate", "up-regulation of substrate-dependent cell migration, cell attachment to substrate", "positive regulation of substrate-bound cell migration, cell attachment to substrate", "upregulation of substrate-dependent cell migration, cell attachment to substrate", "up regulation of substrate-bound cell migration, cell attachment to substrate", "up-regulation of substrate-bound cell migration, cell attachment to substrate", "upregulation of substrate-bound cell migration, cell attachment to substrate"], "types": ["T043"], "canonical_name": "positive regulation of substrate-dependent cell migration, cell attachment to substrate", "definition": "Any process that activates or increases the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate. [GO_REF:0000058, GOC:TermGenie, PMID:25834989]"}
{"concept_id": "C4236278", "aliases": ["down-regulation of substrate-dependent cell migration, cell attachment to substrate", "negative regulation of substrate-bound cell migration, cell attachment to substrate", "down-regulation of substrate-bound cell migration, cell attachment to substrate", "downregulation of substrate-bound cell migration, cell attachment to substrate", "down regulation of substrate-dependent cell migration, cell attachment to substrate", "downregulation of substrate-dependent cell migration, cell attachment to substrate", "down regulation of substrate-bound cell migration, cell attachment to substrate"], "types": ["T043"], "canonical_name": "negative regulation of substrate-dependent cell migration, cell attachment to substrate", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate. [GO_REF:0000058, GOC:TermGenie, PMID:25834989]"}
{"concept_id": "C4236279", "aliases": ["regulation of substrate-bound cell migration, cell attachment to substrate"], "types": ["T043"], "canonical_name": "regulation of substrate-dependent cell migration, cell attachment to substrate", "definition": "Any process that modulates the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate. [GO_REF:0000058, GOC:TermGenie, PMID:25834989]"}
{"concept_id": "C4236280", "aliases": ["upregulation of aconitase activity", "upregulation of cis-aconitase activity", "up regulation of aconitate hydratase activity", "positive regulation of cis-aconitase activity", "up-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "upregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "positive regulation of aconitase activity", "positive regulation of citrate(isocitrate) hydro-lyase activity", "up regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "up regulation of citrate(isocitrate) hydro-lyase activity", "up-regulation of aconitase activity", "up-regulation of cis-aconitase activity", "positive regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "upregulation of citrate(isocitrate) hydro-lyase activity", "up-regulation of citrate(isocitrate) hydro-lyase activity", "up regulation of aconitase activity", "upregulation of aconitate hydratase activity", "up-regulation of aconitate hydratase activity", "up regulation of cis-aconitase activity"], "types": ["T044"], "canonical_name": "positive regulation of aconitate hydratase activity", "definition": "Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]"}
{"concept_id": "C4236281", "aliases": ["down regulation of citrate(isocitrate) hydro-lyase activity", "down-regulation of cis-aconitase activity", "negative regulation of aconitase activity", "down regulation of aconitate hydratase activity", "down-regulation of aconitate hydratase activity", "down-regulation of citrate(isocitrate) hydro-lyase activity", "down-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "downregulation of aconitase activity", "down regulation of aconitase activity", "downregulation of cis-aconitase activity", "down-regulation of aconitase activity", "negative regulation of cis-aconitase activity", "down regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "downregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "negative regulation of citrate(isocitrate) hydro-lyase activity", "negative regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "downregulation of citrate(isocitrate) hydro-lyase activity", "down regulation of cis-aconitase activity", "downregulation of aconitate hydratase activity"], "types": ["T044"], "canonical_name": "negative regulation of aconitate hydratase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aconitate hydratase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]"}
{"concept_id": "C4236282", "aliases": ["regulation of cis-aconitase activity", "regulation of citrate(isocitrate) hydro-lyase activity", "regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)", "regulation of aconitase activity"], "types": ["T044"], "canonical_name": "regulation of aconitate hydratase activity", "definition": "Any process that modulates the frequency, rate or extent of aconitate hydratase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]"}
{"concept_id": "C4236283", "aliases": ["positive regulation of succinodehydrogenase activity", "up-regulation of succinic acid dehydrogenase activity", "positive regulation of fumarate dehydrogenase activity", "upregulation of succinate dehydrogenase activity", "positive regulation of succinate:(acceptor) oxidoreductase activity", "upregulation of fumaric hydrogenase activity", "upregulation of succinyl dehydrogenase activity", "upregulation of fumarate dehydrogenase activity", "positive regulation of fumarate reductase activity", "up regulation of succinic acid dehydrogenase activity", "up regulation of succinate:acceptor oxidoreductase activity", "up-regulation of succinate:acceptor oxidoreductase activity", "up-regulation of succinate:(acceptor) oxidoreductase activity", "upregulation of succinate oxidoreductase activity", "positive regulation of succinic acid dehydrogenase activity", "upregulation of succinate:acceptor oxidoreductase activity", "up-regulation of succinyl dehydrogenase activity", "up regulation of succinate:(acceptor) oxidoreductase activity", "upregulation of fumarate reductase activity", "up regulation of succinodehydrogenase activity", "up regulation of fumarate dehydrogenase activity", "up regulation of fumaric hydrogenase activity", "up regulation of succinyl dehydrogenase activity", "up regulation of succinate dehydrogenase activity", "up-regulation of succinate oxidoreductase activity", "up-regulation of succinodehydrogenase activity", "positive regulation of succinyl dehydrogenase activity", "up regulation of fumarate reductase activity", "upregulation of succinic acid dehydrogenase activity", "up-regulation of fumarate dehydrogenase activity", "positive regulation of succinate:acceptor oxidoreductase activity", "up-regulation of fumaric hydrogenase activity", "upregulation of succinodehydrogenase activity", "up-regulation of succinate dehydrogenase activity", "positive regulation of succinate oxidoreductase activity", "up regulation of succinate oxidoreductase activity", "positive regulation of fumaric hydrogenase activity", "up-regulation of fumarate reductase activity", "upregulation of succinate:(acceptor) oxidoreductase activity"], "types": ["T044"], "canonical_name": "positive regulation of succinate dehydrogenase activity", "definition": "Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]"}
{"concept_id": "C4236284", "aliases": ["downregulation of fumarate reductase activity", "downregulation of fumaric hydrogenase activity", "negative regulation of succinate:acceptor oxidoreductase activity", "negative regulation of fumaric hydrogenase activity", "down regulation of succinate dehydrogenase activity", "down-regulation of fumarate reductase activity", "down-regulation of fumarate dehydrogenase activity", "downregulation of succinodehydrogenase activity", "down-regulation of succinate:(acceptor) oxidoreductase activity", "down-regulation of succinodehydrogenase activity", "negative regulation of fumarate reductase activity", "negative regulation of succinyl dehydrogenase activity", "down regulation of succinyl dehydrogenase activity", "negative regulation of fumarate dehydrogenase activity", "downregulation of succinyl dehydrogenase activity", "down-regulation of fumaric hydrogenase activity", "downregulation of succinate:acceptor oxidoreductase activity", "down regulation of succinic acid dehydrogenase activity", "down regulation of fumarate dehydrogenase activity", "negative regulation of succinic acid dehydrogenase activity", "down-regulation of succinate oxidoreductase activity", "down regulation of fumarate reductase activity", "downregulation of succinate oxidoreductase activity", "negative regulation of succinate oxidoreductase activity", "down-regulation of succinate:acceptor oxidoreductase activity", "down regulation of fumaric hydrogenase activity", "down regulation of succinate oxidoreductase activity", "down-regulation of succinic acid dehydrogenase activity", "down regulation of succinate:(acceptor) oxidoreductase activity", "downregulation of fumarate dehydrogenase activity", "negative regulation of succinodehydrogenase activity", "downregulation of succinate dehydrogenase activity", "downregulation of succinate:(acceptor) oxidoreductase activity", "down regulation of succinodehydrogenase activity", "down regulation of succinate:acceptor oxidoreductase activity", "down-regulation of succinate dehydrogenase activity", "down-regulation of succinyl dehydrogenase activity", "downregulation of succinic acid dehydrogenase activity", "negative regulation of succinate:(acceptor) oxidoreductase activity"], "types": ["T044"], "canonical_name": "negative regulation of succinate dehydrogenase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of succinate dehydrogenase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]"}
{"concept_id": "C4236285", "aliases": ["regulation of succinate:acceptor oxidoreductase activity", "regulation of succinate oxidoreductase activity", "regulation of succinodehydrogenase activity", "regulation of fumarate dehydrogenase activity", "regulation of succinic acid dehydrogenase activity", "regulation of succinate:(acceptor) oxidoreductase activity", "regulation of fumaric hydrogenase activity", "regulation of fumarate reductase activity", "regulation of succinyl dehydrogenase activity"], "types": ["T044"], "canonical_name": "regulation of succinate dehydrogenase activity", "definition": "Any process that modulates the frequency, rate or extent of succinate dehydrogenase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]"}
{"concept_id": "C4236286", "aliases": ["up regulation of glycogen synthase activity, transferring glucose-1-phosphate", "up-regulation of glycogen synthase activity, transferring glucose-1-phosphate", "upregulation of glycogen synthase activity, transferring glucose-1-phosphate"], "types": ["T044"], "canonical_name": "positive regulation of glycogen synthase activity, transferring glucose-1-phosphate", "definition": "Any process that activates or increases the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761]"}
{"concept_id": "C4236287", "aliases": ["down regulation of glycogen synthase activity, transferring glucose-1-phosphate", "downregulation of glycogen synthase activity, transferring glucose-1-phosphate", "down-regulation of glycogen synthase activity, transferring glucose-1-phosphate"], "types": ["T044"], "canonical_name": "negative regulation of glycogen synthase activity, transferring glucose-1-phosphate", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761]"}
{"concept_id": "C4236288", "aliases": [], "types": ["T044"], "canonical_name": "regulation of glycogen synthase activity, transferring glucose-1-phosphate", "definition": "Any process that modulates the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761]"}
{"concept_id": "C4236289", "aliases": ["up-regulation of UDP glucuronic acid transferase activity", "positive regulation of GT activity", "up-regulation of uridine diphosphoglucuronyltransferase activity", "up-regulation of UDP glucuronosyltransferase activity", "upregulation of GT activity", "positive regulation of UDP-glucuronyltransferase activity", "up regulation of uridine 5'-diphosphoglucuronyltransferase activity", "upregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "up-regulation of uridine 5'-diphosphoglucuronyltransferase activity", "up regulation of uridine diphosphoglucuronyltransferase activity", "up-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "positive regulation of UDPGA-glucuronyltransferase activity", "up regulation of UDP glucuronyltransferase activity", "up regulation of UDPGA transferase activity", "up regulation of uridine diphosphoglucuronosyltransferase activity", "up regulation of UDP glucuronic acid transferase activity", "up regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "up regulation of UDP glucuronosyltransferase activity", "up-regulation of glucuronosyltransferase activity", "upregulation of UDPGT activity", "up regulation of GT activity", "positive regulation of UDP-glucuronosyltransferase activity", "positive regulation of UDP glucuronyltransferase activity", "upregulation of uridine 5'-diphosphoglucuronyltransferase activity", "positive regulation of UDPGA transferase activity", "positive regulation of uridine diphosphoglucuronyltransferase activity", "up-regulation of UDPGT activity", "positive regulation of UDP glucuronosyltransferase activity", "up-regulation of uridine diphosphoglucuronosyltransferase activity", "positive regulation of UDPGT activity", "upregulation of UDPGA transferase activity", "upregulation of UDP glucuronosyltransferase activity", "positive regulation of UDP glucuronic acid transferase activity", "up regulation of uridine diphosphate glucuronyltransferase activity", "upregulation of UDP-glucuronyltransferase activity", "upregulation of UDPGA-glucuronyltransferase activity", "upregulation of uridine diphosphate glucuronyltransferase activity", "upregulation of UDP glucuronyltransferase activity", "up-regulation of UDPGA transferase activity", "positive regulation of uridine 5'-diphosphoglucuronyltransferase activity", "up-regulation of UDP-glucuronosyltransferase activity", "up-regulation of uridine diphosphate glucuronyltransferase activity", "upregulation of UDP-glucuronosyltransferase activity", "up-regulation of UDPGA-glucuronyltransferase activity", "up regulation of UDPGT activity", "upregulation of glucuronosyltransferase activity", "upregulation of UDP glucuronic acid transferase activity", "upregulation of uridine diphosphoglucuronosyltransferase activity", "up-regulation of GT activity", "up regulation of UDP-glucuronosyltransferase activity", "up regulation of UDP-glucuronyltransferase activity", "up regulation of glucuronosyltransferase activity", "up-regulation of UDP glucuronyltransferase activity", "up regulation of UDPGA-glucuronyltransferase activity", "up-regulation of UDP-glucuronyltransferase activity", "positive regulation of uridine diphosphoglucuronosyltransferase activity", "positive regulation of uridine diphosphate glucuronyltransferase activity", "positive regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "upregulation of uridine diphosphoglucuronyltransferase activity"], "types": ["T044"], "canonical_name": "positive regulation of glucuronosyltransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of glucuronosyltransferase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558]"}
{"concept_id": "C4236290", "aliases": ["down-regulation of UDPGT activity", "downregulation of uridine diphosphoglucuronyltransferase activity", "down-regulation of uridine 5'-diphosphoglucuronyltransferase activity", "down regulation of uridine diphosphate glucuronyltransferase activity", "down-regulation of UDP-glucuronosyltransferase activity", "downregulation of UDP glucuronyltransferase activity", "down regulation of uridine 5'-diphosphoglucuronyltransferase activity", "down-regulation of UDP-glucuronyltransferase activity", "down-regulation of UDP glucuronosyltransferase activity", "downregulation of UDPGT activity", "down-regulation of UDPGA-glucuronyltransferase activity", "down-regulation of GT activity", "negative regulation of uridine diphosphoglucuronosyltransferase activity", "negative regulation of GT activity", "down-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "down regulation of UDP glucuronic acid transferase activity", "down regulation of glucuronosyltransferase activity", "negative regulation of UDP glucuronic acid transferase activity", "down regulation of UDP-glucuronyltransferase activity", "downregulation of UDP-glucuronosyltransferase activity", "downregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "down regulation of UDPGA transferase activity", "negative regulation of UDP-glucuronyltransferase activity", "down regulation of UDP glucuronyltransferase activity", "downregulation of uridine diphosphate glucuronyltransferase activity", "downregulation of uridine diphosphoglucuronosyltransferase activity", "negative regulation of UDP-glucuronosyltransferase activity", "down-regulation of uridine diphosphate glucuronyltransferase activity", "downregulation of UDPGA-glucuronyltransferase activity", "down-regulation of UDP glucuronic acid transferase activity", "down regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "negative regulation of UDPGT activity", "down regulation of UDPGT activity", "down-regulation of uridine diphosphoglucuronosyltransferase activity", "negative regulation of UDP glucuronosyltransferase activity", "downregulation of uridine 5'-diphosphoglucuronyltransferase activity", "negative regulation of uridine diphosphoglucuronyltransferase activity", "down-regulation of UDP glucuronyltransferase activity", "downregulation of GT activity", "negative regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "down-regulation of glucuronosyltransferase activity", "down regulation of UDP-glucuronosyltransferase activity", "down regulation of uridine diphosphoglucuronosyltransferase activity", "down-regulation of uridine diphosphoglucuronyltransferase activity", "negative regulation of UDPGA transferase activity", "downregulation of UDP-glucuronyltransferase activity", "negative regulation of UDPGA-glucuronyltransferase activity", "down regulation of uridine diphosphoglucuronyltransferase activity", "downregulation of UDP glucuronosyltransferase activity", "downregulation of glucuronosyltransferase activity", "negative regulation of uridine diphosphate glucuronyltransferase activity", "down regulation of UDP glucuronosyltransferase activity", "down regulation of GT activity", "down regulation of UDPGA-glucuronyltransferase activity", "negative regulation of uridine 5'-diphosphoglucuronyltransferase activity", "downregulation of UDPGA transferase activity", "downregulation of UDP glucuronic acid transferase activity", "down-regulation of UDPGA transferase activity", "negative regulation of UDP glucuronyltransferase activity"], "types": ["T044"], "canonical_name": "negative regulation of glucuronosyltransferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronosyltransferase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558]"}
{"concept_id": "C4236291", "aliases": ["regulation of uridine diphosphoglucuronyltransferase activity", "regulation of UDPGA transferase activity", "regulation of UDP-glucuronosyltransferase activity", "regulation of uridine diphosphate glucuronyltransferase activity", "regulation of UDP glucuronic acid transferase activity", "regulation of UDP-glucuronyltransferase activity", "regulation of UDPGT activity", "regulation of uridine diphosphoglucuronosyltransferase activity", "regulation of UDP glucuronyltransferase activity", "regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)", "regulation of UDPGA-glucuronyltransferase activity", "regulation of UDP glucuronosyltransferase activity", "regulation of GT activity", "regulation of uridine 5'-diphosphoglucuronyltransferase activity"], "types": ["T044"], "canonical_name": "regulation of glucuronosyltransferase activity", "definition": "Any process that modulates the frequency, rate or extent of glucuronosyltransferase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558]"}
{"concept_id": "C4236292", "aliases": ["downregulation of serine C-palmitoyltransferase activity", "downregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity", "down regulation of serine C-palmitoyltransferase activity", "down regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity", "down-regulation of 3-oxosphinganine synthetase activity", "down-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity", "negative regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity", "negative regulation of 3-oxosphinganine synthetase activity", "down regulation of 3-oxosphinganine synthetase activity", "down-regulation of serine C-palmitoyltransferase activity", "downregulation of 3-oxosphinganine synthetase activity"], "types": ["T044"], "canonical_name": "negative regulation of serine C-palmitoyltransferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of serine C-palmitoyltransferase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]"}
{"concept_id": "C4236293", "aliases": ["regulation of 3-oxosphinganine synthetase activity", "regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity"], "types": ["T044"], "canonical_name": "regulation of serine C-palmitoyltransferase activity", "definition": "Any process that modulates the frequency, rate or extent of serine C-palmitoyltransferase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]"}
{"concept_id": "C4236294", "aliases": ["up regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity", "upregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity", "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "up-regulation of phosphatidylserine synthase activity", "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "up-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "up regulation of CDP-diglyceride:serine phosphatidyltransferase activity", "upregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity", "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "up-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "up-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity", "positive regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "upregulation of phosphatidylserine synthetase activity", "upregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity", "positive regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity", "upregulation of PS synthase activity", "positive regulation of CDP-diglyceride:serine phosphatidyltransferase activity", "up-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity", "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "upregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "up regulation of PS synthase activity", "up regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity", "up regulation of phosphatidylserine synthetase activity", "positive regulation of PS synthase activity", "up regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity", "up-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "upregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "positive regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity", "positive regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity", "upregulation of phosphatidylserine synthase activity", "up regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "up-regulation of phosphatidylserine synthetase activity", "positive regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "up-regulation of CDP-diglyceride:serine phosphatidyltransferase activity", "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "up regulation of phosphatidylserine synthase activity", "upregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity", "upregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity", "up-regulation of PS synthase activity", "up regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "up regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "up-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity", "up-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity", "positive regulation of phosphatidylserine synthase activity", "upregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "upregulation of CDP-diglyceride:serine phosphatidyltransferase activity", "up regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity", "up-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity", "positive regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity", "positive regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity", "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "positive regulation of phosphatidylserine synthetase activity", "up regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity"], "types": ["T044"], "canonical_name": "positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]"}
{"concept_id": "C4236295", "aliases": ["downregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity", "down regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "down regulation of phosphatidylserine synthase activity", "downregulation of CDP-diglyceride:serine phosphatidyltransferase activity", "downregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity", "downregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity", "down regulation of phosphatidylserine synthetase activity", "down-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "down-regulation of PS synthase activity", "down-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity", "negative regulation of CDP-diglyceride:serine phosphatidyltransferase activity", "down regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "down-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "down-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity", "negative regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "downregulation of phosphatidylserine synthase activity", "down-regulation of phosphatidylserine synthetase activity", "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "down-regulation of CDP-diglyceride:serine phosphatidyltransferase activity", "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "negative regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity", "down regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity", "down regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity", "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "down regulation of CDP-diglyceride:serine phosphatidyltransferase activity", "downregulation of phosphatidylserine synthetase activity", "down-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity", "negative regulation of phosphatidylserine synthetase activity", "negative regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity", "negative regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity", "down regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity", "down regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity", "negative regulation of phosphatidylserine synthase activity", "down-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity", "downregulation of PS synthase activity", "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "downregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "negative regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity", "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "negative regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity", "down-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "down regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity", "down-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity", "downregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "down-regulation of phosphatidylserine synthase activity", "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "downregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "down regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "negative regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "down regulation of PS synthase activity", "downregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity", "downregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity", "negative regulation of PS synthase activity"], "types": ["T044"], "canonical_name": "negative regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]"}
{"concept_id": "C4236296", "aliases": ["regulation of phosphatidylserine synthetase activity", "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity", "regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity", "regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity", "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity", "regulation of phosphatidylserine synthase activity", "regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity", "regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity", "regulation of PS synthase activity", "regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity", "regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity", "regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity", "regulation of CDP-diglyceride:serine phosphatidyltransferase activity"], "types": ["T044"], "canonical_name": "regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "definition": "Any process that modulates the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity. [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]"}
{"concept_id": "C4236297", "aliases": ["up-regulation of protein transport into chloroplast stroma", "up regulation of chloroplast stroma protein import", "up-regulation of protein import into chloroplast stroma", "up-regulation of chloroplast stroma protein import", "positive regulation of protein transport into chloroplast stroma", "up regulation of protein transport into chloroplast stroma", "up regulation of protein import into chloroplast stroma", "upregulation of chloroplast stroma protein import", "upregulation of protein import into chloroplast stroma", "upregulation of protein transport into chloroplast stroma", "positive regulation of chloroplast stroma protein import"], "types": ["T043"], "canonical_name": "positive regulation of protein import into chloroplast stroma", "definition": "Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma. [GO_REF:0000058, GOC:TermGenie, PMID:25901327]"}
{"concept_id": "C4236298", "aliases": ["regulation of chloroplast stroma protein import", "regulation of protein transport into chloroplast stroma"], "types": ["T043"], "canonical_name": "regulation of protein import into chloroplast stroma", "definition": "Any process that modulates the frequency, rate or extent of protein import into chloroplast stroma. [GO_REF:0000058, GOC:TermGenie, PMID:25901327]"}
{"concept_id": "C4236299", "aliases": ["up regulation of iodide transmembrane transport", "upregulation of iodide transmembrane transport", "up-regulation of iodide transmembrane transport"], "types": ["T043"], "canonical_name": "positive regulation of iodide transmembrane transport", "definition": "Any process that activates or increases the frequency, rate or extent of iodide transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:20392814]"}
{"concept_id": "C4236300", "aliases": ["down-regulation of iodide transmembrane transport", "downregulation of iodide transmembrane transport", "down regulation of iodide transmembrane transport"], "types": ["T043"], "canonical_name": "negative regulation of iodide transmembrane transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:20392814]"}
{"concept_id": "C4236301", "aliases": [], "types": ["T043"], "canonical_name": "regulation of iodide transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of iodide transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:20392814]"}
{"concept_id": "C4236302", "aliases": ["membrane protein proteolysis involved in retrograde protein transport, endoplasmic reticulum to cytosol", "membrane protein proteolysis involved in protein dislocation from ER", "membrane protein proteolysis involved in protein retrotranslocation, ER to cytosol", "intramembrane proteolysis involved in ERAD"], "types": ["T044"], "canonical_name": "membrane protein proteolysis involved in retrograde protein transport, ER to cytosol", "definition": "Any membrane protein proteolysis that is involved in retrograde protein transport, ER to cytosol. [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22795130]"}
{"concept_id": "C4236303", "aliases": ["p97-Ufd1-Npl4 complex assembly", "VCP-NPL4-UFD1 AAA ATPase complex formation", "p97-Ufd1-Npl4 complex formation"], "types": ["T044"], "canonical_name": "VCP-NPL4-UFD1 AAA ATPase complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a VCP-NPL4-UFD1 AAA ATPase complex. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]"}
{"concept_id": "C4236307", "aliases": ["upregulation of skeletal muscle hypertrophy", "up-regulation of skeletal muscle hypertrophy", "up regulation of skeletal muscle hypertrophy"], "types": ["T039"], "canonical_name": "positive regulation of skeletal muscle hypertrophy", "definition": "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy. [GO_REF:0000058, GOC:TermGenie, PMID:23470307]"}
{"concept_id": "C4236308", "aliases": ["downregulation of skeletal muscle hypertrophy", "down regulation of skeletal muscle hypertrophy", "down-regulation of skeletal muscle hypertrophy"], "types": ["T039"], "canonical_name": "negative regulation of skeletal muscle hypertrophy", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. [GO_REF:0000058, GOC:TermGenie, PMID:23470307]"}
{"concept_id": "C4236309", "aliases": [], "types": ["T039"], "canonical_name": "regulation of skeletal muscle hypertrophy", "definition": "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy. [GO_REF:0000058, GOC:TermGenie, PMID:23470307]"}
{"concept_id": "C4236310", "aliases": ["up-regulation of iodide transport", "upregulation of iodide transport", "up regulation of iodide transport"], "types": ["T043"], "canonical_name": "positive regulation of iodide transport", "definition": "Any process that activates or increases the frequency, rate or extent of iodide transport. [GO_REF:0000058, GOC:TermGenie, PMID:20392814]"}
{"concept_id": "C4236311", "aliases": ["down regulation of iodide transport", "downregulation of iodide transport", "down-regulation of iodide transport"], "types": ["T043"], "canonical_name": "negative regulation of iodide transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transport. [GO_REF:0000058, GOC:TermGenie, PMID:20392814]"}
{"concept_id": "C4236312", "aliases": [], "types": ["T043"], "canonical_name": "regulation of iodide transport", "definition": "Any process that modulates the frequency, rate or extent of iodide transport. [GO_REF:0000058, GOC:TermGenie, PMID:20392814]"}
{"concept_id": "C4236313", "aliases": [], "types": ["T043"], "canonical_name": "iodide transmembrane transport", "definition": "The process in which iodide is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:20392814]"}
{"concept_id": "C4236314", "aliases": ["positive regulation of regulation of vascular smooth muscle cell membrane depolarization", "upregulation of regulation of vascular smooth muscle cell membrane depolarization", "up-regulation of regulation of vascular smooth muscle cell membrane depolarization", "up regulation of regulation of vascular smooth muscle cell membrane depolarization"], "types": ["T043"], "canonical_name": "positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization", "definition": "Any process that activates or increases the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization. [GO_REF:0000058, GOC:TermGenie, PMID:20826763]"}
{"concept_id": "C4236315", "aliases": ["negative regulation of regulation of vascular smooth muscle cell membrane depolarization", "downregulation of regulation of vascular smooth muscle cell membrane depolarization", "down-regulation of regulation of vascular smooth muscle cell membrane depolarization", "down regulation of regulation of vascular smooth muscle cell membrane depolarization"], "types": ["T043"], "canonical_name": "negative regulation of regulation of vascular associated smooth muscle cell membrane depolarization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization. [GO_REF:0000058, GOC:TermGenie, PMID:20826763]"}
{"concept_id": "C4236316", "aliases": ["up regulation of granulosa cell proliferation", "upregulation of granulosa cell proliferation", "up-regulation of granulosa cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of granulosa cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of granulosa cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:22383759]"}
{"concept_id": "C4236317", "aliases": ["down-regulation of granulosa cell proliferation", "downregulation of granulosa cell proliferation", "down regulation of granulosa cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of granulosa cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:22383759]"}
{"concept_id": "C4236318", "aliases": [], "types": ["T043"], "canonical_name": "regulation of granulosa cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of granulosa cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:22383759]"}
{"concept_id": "C4236319", "aliases": ["positive regulation of epithelial cell of bile duct apoptotic process", "up regulation of epithelial cell of bile duct apoptotic process", "up regulation of cholangiocyte apoptotic process", "upregulation of cholangiocyte apoptotic process", "upregulation of epithelial cell of bile duct apoptotic process", "up-regulation of epithelial cell of bile duct apoptotic process", "up-regulation of cholangiocyte apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of cholangiocyte apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24498161]"}
{"concept_id": "C4236320", "aliases": ["down-regulation of cholangiocyte apoptotic process", "downregulation of epithelial cell of bile duct apoptotic process", "downregulation of cholangiocyte apoptotic process", "down regulation of cholangiocyte apoptotic process", "negative regulation of epithelial cell of bile duct apoptotic process", "down regulation of epithelial cell of bile duct apoptotic process", "down-regulation of epithelial cell of bile duct apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of cholangiocyte apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24498161]"}
{"concept_id": "C4236321", "aliases": ["regulation of epithelial cell of bile duct apoptotic process"], "types": ["T043"], "canonical_name": "regulation of cholangiocyte apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24498161]"}
{"concept_id": "C4236322", "aliases": ["upregulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division", "up regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division", "up-regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division", "positive regulation of CDK activity involved in meiotic nuclear division"], "types": ["T043"], "canonical_name": "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division", "definition": "Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division. [GO_REF:0000060, GOC:TermGenie, PMID:15791259]"}
{"concept_id": "C4236323", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of APC-fizzy related complex activity"}
{"concept_id": "C4236324", "aliases": ["up-regulation of viral transformation", "positive regulation of viral transformation of host cell", "upregulation of transformation of host cell by virus", "up regulation of viral transformation", "up-regulation of transformation of host cell by virus", "upregulation of viral transformation of host cell", "upregulation of viral transformation", "up regulation of viral transformation of host cell", "up-regulation of viral transformation of host cell", "positive regulation of viral transformation", "up regulation of transformation of host cell by virus"], "types": ["T038"], "canonical_name": "positive regulation of transformation of host cell by virus", "definition": "Any process that activates or increases the frequency, rate or extent of transformation of host cell by virus. [GO_REF:0000058, GOC:TermGenie, PMID:12200142]"}
{"concept_id": "C4236325", "aliases": ["down-regulation of viral transformation of host cell", "down-regulation of transformation of host cell by virus", "down regulation of viral transformation", "downregulation of viral transformation of host cell", "down regulation of viral transformation of host cell", "downregulation of viral transformation", "down regulation of transformation of host cell by virus", "downregulation of transformation of host cell by virus", "down-regulation of viral transformation", "negative regulation of viral transformation of host cell", "negative regulation of viral transformation"], "types": ["T038"], "canonical_name": "negative regulation of transformation of host cell by virus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transformation of host cell by virus. [GO_REF:0000058, GOC:TermGenie, PMID:12200142]"}
{"concept_id": "C4236326", "aliases": ["regulation of viral transformation", "regulation of viral transformation of host cell"], "types": ["T043"], "canonical_name": "regulation of transformation of host cell by virus", "definition": "Any process that modulates the frequency, rate or extent of transformation of host cell by virus. [GO_REF:0000058, GOC:TermGenie, PMID:12200142]"}
{"concept_id": "C4236327", "aliases": ["PAA organization", "post-anaphase array organization", "post-anaphase microtubule array organisation"], "types": ["T043"], "canonical_name": "post-anaphase microtubule array organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly ofa post-anaphase microtubule array. [GOC:TermGenie, PMID:15004232]"}
{"concept_id": "C4236328", "aliases": ["EMTOC assembly", "equatorial microtubule organizing center formation", "EMTOC formation", "equatorial microtubule organising centre assembly", "equatorial microtubule organising centre formation"], "types": ["T043"], "canonical_name": "equatorial microtubule organizing center assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an equatorial microtubule organizing center. [GO_REF:0000079, GOC:TermGenie, PMID:15004232]"}
{"concept_id": "C4236329", "aliases": ["upregulation of pyruvic dehydrogenase activity", "upregulation of pyruvic acid dehydrogenase activity", "up-regulation of pyruvate dehydrogenase activity", "up regulation of pyruvate dehydrogenase activity", "up-regulation of pyruvic dehydrogenase activity", "positive regulation of pyruvic acid dehydrogenase activity", "upregulation of pyruvate dehydrogenase activity", "up-regulation of pyruvic acid dehydrogenase activity", "positive regulation of pyruvic dehydrogenase activity", "up regulation of pyruvic dehydrogenase activity", "up regulation of pyruvic acid dehydrogenase activity"], "types": ["T044"], "canonical_name": "positive regulation of pyruvate dehydrogenase activity", "definition": "Any process that activates or increases the frequency, rate or extent of pyruvate dehydrogenase activity. [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879]"}
{"concept_id": "C4236330", "aliases": ["downregulation of pyruvic dehydrogenase activity", "down-regulation of pyruvic acid dehydrogenase activity", "downregulation of pyruvate dehydrogenase activity", "downregulation of pyruvic acid dehydrogenase activity", "down regulation of pyruvic dehydrogenase activity", "negative regulation of pyruvic acid dehydrogenase activity", "negative regulation of pyruvic dehydrogenase activity", "down-regulation of pyruvic dehydrogenase activity", "down regulation of pyruvic acid dehydrogenase activity", "down regulation of pyruvate dehydrogenase activity", "down-regulation of pyruvate dehydrogenase activity"], "types": ["T044"], "canonical_name": "negative regulation of pyruvate dehydrogenase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate dehydrogenase activity. [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879]"}
{"concept_id": "C4236331", "aliases": ["regulation of pyruvic acid dehydrogenase activity", "regulation of pyruvic dehydrogenase activity"], "types": ["T044"], "canonical_name": "regulation of pyruvate dehydrogenase activity", "definition": "Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity. [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879]"}
{"concept_id": "C4236332", "aliases": ["downregulation of membrane depolarization", "down-regulation of membrane depolarization", "down regulation of membrane depolarization"], "types": ["T043"], "canonical_name": "negative regulation of membrane depolarization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization. [GO_REF:0000058, GOC:TermGenie, PMID:20826763]"}
{"concept_id": "C4236333", "aliases": ["up-regulation of adipose tissue development", "up regulation of adipose tissue development", "upregulation of adipose tissue development"], "types": ["T039"], "canonical_name": "positive regulation of adipose tissue development", "definition": "Any process that activates or increases the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]"}
{"concept_id": "C4236334", "aliases": ["down regulation of adipose tissue development", "down-regulation of adipose tissue development", "downregulation of adipose tissue development"], "types": ["T039"], "canonical_name": "negative regulation of adipose tissue development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]"}
{"concept_id": "C4236335", "aliases": [], "types": ["T038"], "canonical_name": "regulation of adipose tissue development", "definition": "Any process that modulates the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]"}
{"concept_id": "C4236336", "aliases": ["up-regulation of histone demethylase activity (H3-K4 specific)", "up regulation of histone demethylase activity (H3-K4 specific)", "upregulation of histone demethylase activity (H3-K4 specific)"], "types": ["T044"], "canonical_name": "positive regulation of histone demethylase activity (H3-K4 specific)", "definition": "Any process that activates or increases the frequency, rate or extent of histone demethylase activity (H3-K4 specific). [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136]"}
{"concept_id": "C4236337", "aliases": ["down regulation of histone demethylase activity (H3-K4 specific)", "down-regulation of histone demethylase activity (H3-K4 specific)", "downregulation of histone demethylase activity (H3-K4 specific)"], "types": ["T044"], "canonical_name": "negative regulation of histone demethylase activity (H3-K4 specific)", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone demethylase activity (H3-K4 specific). [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136]"}
{"concept_id": "C4236338", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone demethylase activity (H3-K4 specific)", "definition": "Any process that modulates the frequency, rate or extent of histone demethylase activity (H3-K4 specific). [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136]"}
{"concept_id": "C4236339", "aliases": ["positive regulation of cell blebbing", "upregulation of cell blebbing", "up-regulation of cell blebbing", "up regulation of bleb assembly", "up-regulation of bleb assembly", "upregulation of bleb assembly", "up regulation of cell blebbing"], "types": ["T043"], "canonical_name": "positive regulation of bleb assembly", "definition": "Any process that activates or increases the frequency, rate or extent of bleb assembly. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]"}
{"concept_id": "C4236340", "aliases": ["down-regulation of cell blebbing", "negative regulation of cell blebbing", "downregulation of bleb assembly", "down regulation of bleb assembly", "down regulation of cell blebbing", "downregulation of cell blebbing", "down-regulation of bleb assembly"], "types": ["T043"], "canonical_name": "negative regulation of bleb assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]"}
{"concept_id": "C4236341", "aliases": ["regulation of cell blebbing"], "types": ["T043"], "canonical_name": "regulation of bleb assembly", "definition": "Any process that modulates the frequency, rate or extent of bleb assembly. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]"}
{"concept_id": "C4236342", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of thyroid hormone receptor activity"}
{"concept_id": "C4236343", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of thyroid hormone receptor activity"}
{"concept_id": "C4236344", "aliases": [], "types": ["T045"], "canonical_name": "regulation of thyroid hormone receptor activity"}
{"concept_id": "C4236346", "aliases": ["DNA synthesis involved in UVDE-dependent excision repair", "DNA synthesis involved in UV-damaged DNA endonuclease-dependent excision repair", "DNA synthesis involved in UVER"], "types": ["T045"], "canonical_name": "DNA synthesis involved in UV-damage excision repair", "definition": "Any DNA synthesis that is involved in UV-damage excision repair. [GO_REF:0000060, GOC:TermGenie, PMID:10704216]"}
{"concept_id": "C4236347", "aliases": ["protein localization in chloroplast starch grain", "protein localisation to chloroplast starch grain", "protein localisation in chloroplast starch grain"], "types": ["T043"], "canonical_name": "protein localization to chloroplast starch grain", "definition": "A process in which a protein is transported to, or maintained in, a location within a chloroplast starch grain. [GO_REF:0000087, GOC:TermGenie, PMID:25710501]"}
{"concept_id": "C4236348", "aliases": ["megaspore mother cell differentiation"], "types": ["T043"], "canonical_name": "megasporocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a megasporocyte. [GO_REF:0000086, GOC:tair_curators, GOC:TermGenie]"}
{"concept_id": "C4236349", "aliases": ["axonemal central apparatus formation"], "types": ["T043"], "canonical_name": "axonemal central apparatus assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus. [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:9295136]"}
{"concept_id": "C4236350", "aliases": [], "types": ["T043"], "canonical_name": "DN4 thymocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a DN4 thymocyte. A DN4 thymocyte is a CD4-,CD8- thymocyte that is also CD44-,CD25-. [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325]"}
{"concept_id": "C4236351", "aliases": [], "types": ["T043"], "canonical_name": "DN3 thymocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a DN3 thymocyte. A DN3 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25+. [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325]"}
{"concept_id": "C4236352", "aliases": [], "types": ["T043"], "canonical_name": "DN2 thymocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a DN2 thymocyte. A DN2 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25-. [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325]"}
{"concept_id": "C4236353", "aliases": ["upregulation of protein dislocation from ER", "up-regulation of protein dislocation from ER", "positive regulation of protein retrotranslocation from ER", "upregulation of retrograde protein transport, ER to cytosol", "up regulation of protein dislocation from ER", "positive regulation of protein dislocation from ER", "up-regulation of retrograde protein transport, endoplasmic reticulum to cytosol", "positive regulation of retrograde protein transport, endoplasmic reticulum to cytosol", "up-regulation of protein retrotranslocation from ER", "upregulation of retrograde protein transport, endoplasmic reticulum to cytosol", "up-regulation of retrograde protein transport, ER to cytosol", "up regulation of retrograde protein transport, endoplasmic reticulum to cytosol", "up regulation of retrograde protein transport, ER to cytosol"], "types": ["T043"], "canonical_name": "positive regulation of retrograde protein transport, ER to cytosol", "definition": "Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]"}
{"concept_id": "C4236354", "aliases": ["regulation of protein retrotranslocation from ER", "regulation of retrograde protein transport, endoplasmic reticulum to cytosol", "regulation of protein dislocation from ER"], "types": ["T043"], "canonical_name": "regulation of retrograde protein transport, ER to cytosol", "definition": "Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]"}
{"concept_id": "C4236355", "aliases": ["upregulation of microglial cell mediated cytotoxicity", "up regulation of microglial cell mediated cytotoxicity", "up-regulation of microglial cell mediated cytotoxicity"], "types": ["T043"], "canonical_name": "positive regulation of microglial cell mediated cytotoxicity", "definition": "Any process that activates or increases the frequency, rate or extent of microglial cell mediated cytotoxicity. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C4236356", "aliases": ["downregulation of microglial cell mediated cytotoxicity", "down regulation of microglial cell mediated cytotoxicity", "down-regulation of microglial cell mediated cytotoxicity"], "types": ["T043"], "canonical_name": "negative regulation of microglial cell mediated cytotoxicity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell mediated cytotoxicity. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C4236357", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microglial cell mediated cytotoxicity", "definition": "Any process that modulates the frequency, rate or extent of microglial cell mediated cytotoxicity. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C4236358", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to nonylphenol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:19260726]"}
{"concept_id": "C4236359", "aliases": [], "types": ["T043"], "canonical_name": "response to nonylphenol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:19260726]"}
{"concept_id": "C4236360", "aliases": ["up regulation of meiotic cell cycle process involved in oocyte maturation", "upregulation of meiotic cell cycle process involved in oocyte maturation", "up-regulation of meiotic cell cycle process involved in oocyte maturation"], "types": ["T044"], "canonical_name": "positive regulation of meiotic cell cycle process involved in oocyte maturation", "definition": "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. [GO_REF:0000058, GOC:TermGenie, PMID:22674394]"}
{"concept_id": "C4236361", "aliases": ["downregulation of meiotic cell cycle process involved in oocyte maturation", "down-regulation of meiotic cell cycle process involved in oocyte maturation", "down regulation of meiotic cell cycle process involved in oocyte maturation"], "types": ["T043"], "canonical_name": "negative regulation of meiotic cell cycle process involved in oocyte maturation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. [GO_REF:0000058, GOC:TermGenie, PMID:22674394]"}
{"concept_id": "C4236362", "aliases": ["down-regulation of carotenoid biosynthetic process", "down regulation of carotenoid biosynthesis", "down-regulation of carotenoid synthesis", "negative regulation of carotenoid anabolism", "downregulation of carotenoid biosynthesis", "down regulation of carotenoid biosynthetic process", "down regulation of carotenoid anabolism", "negative regulation of carotenoid formation", "downregulation of carotenoid formation", "down regulation of carotenoid synthesis", "negative regulation of carotenoid synthesis", "down-regulation of carotenoid anabolism", "downregulation of carotenoid biosynthetic process", "negative regulation of carotenoid biosynthesis", "downregulation of carotenoid synthesis", "down-regulation of carotenoid biosynthesis", "down regulation of carotenoid formation", "down-regulation of carotenoid formation", "downregulation of carotenoid anabolism"], "types": ["T044"], "canonical_name": "negative regulation of carotenoid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of carotenoid biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:25675505]"}
{"concept_id": "C4236363", "aliases": ["up regulation of microglial cell migration", "upregulation of microglial cell migration", "up-regulation of microglial cell migration"], "types": ["T043"], "canonical_name": "positive regulation of microglial cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of microglial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C4236364", "aliases": ["down-regulation of microglial cell migration", "down regulation of microglial cell migration", "downregulation of microglial cell migration"], "types": ["T043"], "canonical_name": "negative regulation of microglial cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C4236365", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microglial cell migration", "definition": "Any process that modulates the frequency, rate or extent of microglial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C4236366", "aliases": ["up regulation of convergent extension involved in notochord morphogenesis", "up-regulation of convergent extension involved in notochord morphogenesis", "upregulation of convergent extension involved in notochord morphogenesis"], "types": ["T039"], "canonical_name": "positive regulation of convergent extension involved in notochord morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of convergent extension involved in notochord morphogenesis. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236367", "aliases": ["downregulation of convergent extension involved in notochord morphogenesis", "down-regulation of convergent extension involved in notochord morphogenesis", "down regulation of convergent extension involved in notochord morphogenesis"], "types": ["T042"], "canonical_name": "negative regulation of convergent extension involved in notochord morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in notochord morphogenesis. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236368", "aliases": [], "types": ["T042"], "canonical_name": "regulation of convergent extension involved in notochord morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of convergent extension involved in notochord morphogenesis. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236369", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of convergent extension involved in rhombomere morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236370", "aliases": ["down regulation of convergent extension involved in rhombomere morphogenesis", "downregulation of convergent extension involved in rhombomere morphogenesis", "down-regulation of convergent extension involved in rhombomere morphogenesis"], "types": ["T043"], "canonical_name": "negative regulation of convergent extension involved in rhombomere morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236371", "aliases": [], "types": ["T042"], "canonical_name": "regulation of convergent extension involved in rhombomere morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236372", "aliases": ["up regulation of convergent extension involved in neural plate elongation", "upregulation of convergent extension involved in neural plate elongation", "up-regulation of convergent extension involved in neural plate elongation"], "types": ["T043"], "canonical_name": "positive regulation of convergent extension involved in neural plate elongation", "definition": "Any process that activates or increases the frequency, rate or extent of convergent extension involved in neural plate elongation. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236373", "aliases": ["down regulation of convergent extension involved in neural plate elongation", "downregulation of convergent extension involved in neural plate elongation", "down-regulation of convergent extension involved in neural plate elongation"], "types": ["T043"], "canonical_name": "negative regulation of convergent extension involved in neural plate elongation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in neural plate elongation. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236374", "aliases": [], "types": ["T042"], "canonical_name": "regulation of convergent extension involved in neural plate elongation", "definition": "Any process that modulates the frequency, rate or extent of convergent extension involved in neural plate elongation. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236375", "aliases": ["up regulation of convergent extension involved in somitogenesis", "upregulation of convergent extension involved in somitogenesis", "up-regulation of convergent extension involved in somitogenesis"], "types": ["T038"], "canonical_name": "positive regulation of convergent extension involved in somitogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of convergent extension involved in somitogenesis. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236376", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of convergent extension involved in somitogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in somitogenesis. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236377", "aliases": [], "types": ["T039"], "canonical_name": "regulation of convergent extension involved in somitogenesis", "definition": "Any process that modulates the frequency, rate or extent of convergent extension involved in somitogenesis. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236378", "aliases": [], "types": ["T042"], "canonical_name": "convergent extension involved in notochord morphogenesis", "definition": "Any convergent extension that is involved in notochord morphogenesis. [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236379", "aliases": [], "types": ["T042"], "canonical_name": "convergent extension involved in rhombomere morphogenesis", "definition": "Any convergent extension that is involved in rhombomere morphogenesis. [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953]"}
{"concept_id": "C4236380", "aliases": [], "types": ["T043"], "canonical_name": "microglial cell migration", "definition": "The orderly movement of a microglial cell from one site to another. [GO_REF:0000091, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]"}
{"concept_id": "C4236381", "aliases": ["up regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway", "upregulation of fatty acid beta-oxidation by serotonin receptor signaling pathway", "up-regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway", "definition": "A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation. [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942]"}
{"concept_id": "C4236382", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of fatty acid beta-oxidation by octopamine signaling pathway", "definition": "An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation. [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942]"}
{"concept_id": "C4236383", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylethanolamine transporter activity"}
{"concept_id": "C4236384", "aliases": ["up regulation of otic vesicle morphogenesis", "upregulation of otic vesicle morphogenesis", "up-regulation of otic vesicle morphogenesis"], "types": ["T043"], "canonical_name": "positive regulation of otic vesicle morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of otic vesicle morphogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:25677106]"}
{"concept_id": "C4236385", "aliases": ["down-regulation of otic vesicle morphogenesis", "downregulation of otic vesicle morphogenesis", "down regulation of otic vesicle morphogenesis"], "types": ["T043"], "canonical_name": "negative regulation of otic vesicle morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of otic vesicle morphogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:25677106]"}
{"concept_id": "C4236386", "aliases": [], "types": ["T042"], "canonical_name": "regulation of otic vesicle morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of otic vesicle morphogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:25677106]"}
{"concept_id": "C4236387", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to vasopressin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22811487]"}
{"concept_id": "C4236388", "aliases": [], "types": ["T039"], "canonical_name": "response to vasopressin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22811487]"}
{"concept_id": "C4236389", "aliases": ["up regulation of muscle filament sliding", "upregulation of muscle filament sliding", "up-regulation of muscle filament sliding"], "types": ["T043"], "canonical_name": "positive regulation of muscle filament sliding", "definition": "Any process that activates or increases the frequency, rate or extent of muscle filament sliding. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181]"}
{"concept_id": "C4236390", "aliases": ["down-regulation of muscle filament sliding", "downregulation of muscle filament sliding", "down regulation of muscle filament sliding"], "types": ["T043"], "canonical_name": "negative regulation of muscle filament sliding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of muscle filament sliding. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181]"}
{"concept_id": "C4236394", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "definition": "Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel. [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048]"}
{"concept_id": "C4236395", "aliases": [], "types": ["T044"], "canonical_name": "UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity", "definition": "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] <=> UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]. [EC:2.3.1.191, GOC:pz]"}
{"concept_id": "C4236396", "aliases": [], "types": ["T044"], "canonical_name": "UDP-3-O-acyl-N-acetylglucosamine deacetylase activity", "definition": "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate. [EC:3.5.1.108, GOC:pz]"}
{"concept_id": "C4236397", "aliases": ["alpha-D-galactofuranose transporter activity", "ATPase-coupled alpha-D-galactofuranose transporter activity", "ATP-dependent alpha-D-galactofuranose transporter activity"], "types": ["T044"], "canonical_name": "ABC-type D-galactofuranose transporter", "definition": "Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+. [GOC:pz, PMID:19744923, RHEA:61716]"}
{"concept_id": "C4236398", "aliases": [], "types": ["T044"], "canonical_name": "protoheme IX ABC transporter activity"}
{"concept_id": "C4236400", "aliases": [], "types": ["T044"], "canonical_name": "D-glucosamine PTS permease activity", "definition": "Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine <=> D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine. [EC:2.7.1.69, GOC:pz]"}
{"concept_id": "C4236401", "aliases": [], "types": ["T044"], "canonical_name": "castasterone 23-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: castasterone + UDP-alpha-D-glucose <=> castasterone-23-O-glucoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236402", "aliases": [], "types": ["T044"], "canonical_name": "brassinolide 23-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose <=> brassinolide-23-O-glucoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236403", "aliases": [], "types": ["T044"], "canonical_name": "2-oxo-6-methylthiohexanoate aminotransferase activity", "definition": "Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid <=> dihomomethionine + a 2-oxo carboxylate. [EC:2.6.1.-, GOC:pz]"}
{"concept_id": "C4236404", "aliases": [], "types": ["T044"], "canonical_name": "6-methylthiohexyldesulfoglucosinolate sulfotransferase activity", "definition": "Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate <=> adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate. [EC:2.8.2.-, GOC:pz]"}
{"concept_id": "C4236405", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate <=> 8-methylthiooctyldesulfoglucosinolate + UDP + H+. [EC:2.4.1.195, GOC:pz]"}
{"concept_id": "C4236406", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate <=> H+ + 7-methylthioheptyldesulfoglucosinolate + UDP. [EC:2.4.1.195, GOC:pz]"}
{"concept_id": "C4236407", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate <=> H+ + 6-methylthiohexyldesulfoglucosinolate + UDP. [EC:2.4.1.195, GOC:pz]"}
{"concept_id": "C4236408", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate <=> H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-). [EC:2.4.1.195, GOC:pz]"}
{"concept_id": "C4236409", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate <=> H+ + 4-methylthiobutyldesulfoglucosinolate + UDP. [EC:2.4.1.195, GOC:pz]"}
{"concept_id": "C4236410", "aliases": [], "types": ["T044"], "canonical_name": "CYP79F1 tetrahomomethionine monooxygenase activity", "definition": "Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH <=> 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4236411", "aliases": [], "types": ["T044"], "canonical_name": "CYP79F1 trihomomethionine monooxygenase activity", "definition": "Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4236412", "aliases": [], "types": ["T044"], "canonical_name": "CYP79F1 dihomomethionine monooxygenase activity", "definition": "Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4236413", "aliases": [], "types": ["T044"], "canonical_name": "methylthioalkylmalate dehydrogenase activity", "definition": "Catalysis of the reaction: 3-(7'-methylthio)heptylmalate <=> H+ + 2-oxo-10-methylthiodecanoate + carbon dioxide. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4236414", "aliases": [], "types": ["T044"], "canonical_name": "methylthioalkylmalate isomerase activity", "definition": "Catalysis of the reaction: 2-(7'-methylthio)heptylmalate <=> 3-(7'-methylthio)heptylmalate. [EC:5.4.4.-, GOC:pz]"}
{"concept_id": "C4236415", "aliases": [], "types": ["T044"], "canonical_name": "2-(7'-methylthio)heptylmalate synthase activity", "definition": "Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O <=> H+ + 2-(7'-methylthio)heptylmalate + coenzyme A. [EC:2.3.3.-, GOC:pz]"}
{"concept_id": "C4236416", "aliases": [], "types": ["T044"], "canonical_name": "2-(6'-methylthio)hexylmalate synthase activity", "definition": "Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O <=> H+ + 2-(6'-methylthio)hexylmalate + coenzyme A. [EC:2.3.3.-, GOC:pz]"}
{"concept_id": "C4236417", "aliases": [], "types": ["T044"], "canonical_name": "2-(5'-methylthio)pentylmalate synthase activity", "definition": "Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O <=> H+ + 2-(5'-methylthio)pentylmalate + coenzyme A. [EC:2.3.3.-, GOC:pz]"}
{"concept_id": "C4236418", "aliases": [], "types": ["T044"], "canonical_name": "2-(4'-methylthio)butylmalate synthase activity", "definition": "Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O <=> H+ + 2-(4'-methylthio)butylmalate + coenzyme A. [EC:2.3.3.-, GOC:pz]"}
{"concept_id": "C4236419", "aliases": [], "types": ["T044"], "canonical_name": "2-(3'-methylthio)propylmalate synthase activity", "definition": "Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-(3-methylthiopropyl)malate + coenzyme A. [EC:2.3.3.-, GOC:pz]"}
{"concept_id": "C4236420", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236421", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3-glucoside 7-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose <=> quercetin-3-O-glucoside-7-O-rhamnoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236422", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-pyruvate monooxygenase activity", "definition": "Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ <=> indole-3-acetate + carbon dioxide + NADP + H2O. [EC:1.14.13.168, GOC:pz]"}
{"concept_id": "C4236423", "aliases": [], "types": ["T044"], "canonical_name": "anandamide amidohydrolase activity", "definition": "Catalysis of the reaction: anandamide + H2O <=> arachidonate + ethanolaminium(1+). [EC:3.5.1.99, GOC:pz]"}
{"concept_id": "C4236424", "aliases": [], "types": ["T044"], "canonical_name": "17-hydroxyprogesterone 21-hydroxylase activity", "definition": "Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:pz, RHEA:50308]"}
{"concept_id": "C4236425", "aliases": [], "types": ["T044"], "canonical_name": "trans-keto-C61-meroacyl-AMP ligase activity", "definition": "Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] <=> diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]. [EC:6.2.1.-, GOC:pz]"}
{"concept_id": "C4236426", "aliases": [], "types": ["T044"], "canonical_name": "cis-keto-C60-meroacyl-AMP ligase activity", "definition": "Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] <=> diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]. [EC:6.2.1.-, GOC:pz]"}
{"concept_id": "C4236427", "aliases": [], "types": ["T044"], "canonical_name": "trans-methoxy-C60-meroacyl-AMP ligase activity", "definition": "Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] <=> diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]. [GOC:pz, PMID:15042094]"}
{"concept_id": "C4236428", "aliases": [], "types": ["T044"], "canonical_name": "kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose <=> kaempferol-3-rhamnoside-7-rhamnoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236429", "aliases": [], "types": ["T044"], "canonical_name": "UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose <=> H+ + kaempferol-3-rhamnoside + UDP(3-). [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236430", "aliases": [], "types": ["T044"], "canonical_name": "kaempferol 3-glucoside 7-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose <=> kaempferol-3-glucoside-7-rhamnoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236431", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate <=> H+ + gibberellin A20 + 2 carbon dioxide + succinate. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4236432", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate <=> gibberellin A44 diacid + carbon dioxide + succinate. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4236433", "aliases": [], "types": ["T044"], "canonical_name": "gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4236434", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming)", "definition": "Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate <=> gibberellin A15 + carbon dioxide + succinate. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4236435", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxy-L-threonine aldolase activity", "definition": "Catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine. [GOC:pz, RHEA:28779]"}
{"concept_id": "C4236437", "aliases": [], "types": ["T044"], "canonical_name": "mannosylfructose-phosphate synthase activity", "definition": "Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate <=> mannosylfructose-phosphate + GDP. [EC:2.4.1.246, GOC:pz]"}
{"concept_id": "C4236438", "aliases": [], "types": ["T044"], "canonical_name": "9,10-epoxystearate hydrolase activity", "definition": "Catalysis of the reaction: 9,10-epoxystearate + H2O <=> (9R,10S)-dihydroxystearate. [EC:3.3.2.-, GOC:pz]"}
{"concept_id": "C4236439", "aliases": [], "types": ["T044"], "canonical_name": "(gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide. [GOC:pz]"}
{"concept_id": "C4236440", "aliases": [], "types": ["T044"], "canonical_name": "(gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate. [GOC:pz]"}
{"concept_id": "C4236441", "aliases": [], "types": ["T044"], "canonical_name": "p-coumaroyltriacetic acid synthase activity", "definition": "Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA <=> 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4236442", "aliases": [], "types": ["T044"], "canonical_name": "cirsimaritin 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine <=> salvigenin + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4236443", "aliases": [], "types": ["T044"], "canonical_name": "scutellarein 7-methyl ether 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> ladanein + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4236444", "aliases": [], "types": ["T044"], "canonical_name": "scutellarein 7-methyl ether 6-O-methyltransferase activity", "definition": "Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> cirsimaritin + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4236445", "aliases": [], "types": ["T044"], "canonical_name": "linuron hydrolase activity", "definition": "Catalysis of the reaction: linuron + H2O <=> N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline. [EC:3.5.1.-, GOC:pz]"}
{"concept_id": "C4236446", "aliases": [], "types": ["T044"], "canonical_name": "germacrene A acid 8beta-hydroxylase activity", "definition": "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ <=> 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4236447", "aliases": [], "types": ["T044"], "canonical_name": "trimethyluric acid monooxygenase activity", "definition": "Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O. [GOC:pz, RHEA:48992]"}
{"concept_id": "C4236448", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) <=> cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4236449", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 6''-O-malonyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA <=> cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A. [EC:2.3.1.171, GOC:pz]"}
{"concept_id": "C4236450", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236451", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4236452", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A. [GOC:pz, PMID:17292360]"}
{"concept_id": "C4236453", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+. [GOC:pz, PMID:15807784]"}
{"concept_id": "C4236454", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4236455", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+. [EC:2.4.2.-, GOC:pz]"}
{"concept_id": "C4236456", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside-p-coumaroyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ <=> cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4236457", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP. [EC:2.4.2.51, GOC:pz]"}
{"concept_id": "C4236458", "aliases": [], "types": ["T044"], "canonical_name": "esculetin glucosyltransferase activity", "definition": "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) <=> esculin + UDP(3-) + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236459", "aliases": [], "types": ["T044"], "canonical_name": "scopolin beta-glucosidase activity", "definition": "Catalysis of the reaction: H2O + scopolin <=> beta-D-glucose + scopoletin. [EC:3.2.1.21, GOC:pz]"}
{"concept_id": "C4236460", "aliases": [], "types": ["T044"], "canonical_name": "patchoulol synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> seychellene + diphosphoric acid. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4236461", "aliases": [], "types": ["T044"], "canonical_name": "19-O-beta-glucopyranosyl-steviol glucosyltransferase activity", "definition": "Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose <=> rubusoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236462", "aliases": [], "types": ["T044"], "canonical_name": "steviol 19-O glucosyltransferase activity", "definition": "Catalysis of the reaction: steviol + UDP-alpha-D-glucose <=> 19-O-beta-glucopyranosyl-steviol + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4236463", "aliases": [], "types": ["T044"], "canonical_name": "1,8-cineole synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate(3-) + H2O <=> 1,8-cineole + diphosphoric acid. [GOC:pz, RHEA:32543]"}
{"concept_id": "C4236464", "aliases": [], "types": ["T044"], "canonical_name": "4-coumaroyl 2'-hydroxylase activity", "definition": "Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide. [GOC:pz, PMID:22168819, PMID:22169019]"}
{"concept_id": "C4236465", "aliases": [], "types": ["T044"], "canonical_name": "linolenate 9R-lipoxygenase activity", "definition": "Catalysis of the reaction: alpha-linolenate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate. [EC:1.13.11.61, GOC:pz]"}
{"concept_id": "C4236466", "aliases": [], "types": ["T044"], "canonical_name": "lecithin:11-cis retinol acyltransferase activity", "definition": "Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine <=> a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine. [EC:2.3.1.135, GOC:pz]"}
{"concept_id": "C4236468", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-beta-apo-10'-carotenal cleavage oxygenase activity", "definition": "Catalysis of the reaction: 10'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial. [EC:1.13.11.70, GOC:pz]"}
{"concept_id": "C4236469", "aliases": [], "types": ["T044"], "canonical_name": "soyasaponin III rhamnosyltransferase activity", "definition": "Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III <=> H+ + UDP + soyasaponin I. [EC:2.4.1.273, GOC:pz]"}
{"concept_id": "C4236470", "aliases": [], "types": ["T044"], "canonical_name": "soyasapogenol B glucuronide galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate <=> H+ + UDP + soyasaponin III. [EC:2.4.1.272, GOC:pz]"}
{"concept_id": "C4236471", "aliases": [], "types": ["T044"], "canonical_name": "unsaturated rhamnogalacturonyl hydrolase activity", "definition": "Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose. [EC:3.2.1.172, GOC:pz]"}
{"concept_id": "C4236472", "aliases": [], "types": ["T044"], "canonical_name": "rhamnogalacturonan endolyase activity", "definition": "Catalysis of the reaction: H2O + a rhamnogalacturonan type I <=> [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]. [EC:4.2.2.23, GOC:pz]"}
{"concept_id": "C4236473", "aliases": [], "types": ["T044"], "canonical_name": "trans-permethrin hydrolase activity", "definition": "Catalysis of the reaction: (-)-trans-permethrin + H2O <=> H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate. [EC:3.1.1.88, GOC:pz]"}
{"concept_id": "C4236474", "aliases": [], "types": ["T044"], "canonical_name": "cycloeucalenone reductase activity", "definition": "Catalysis of the reaction: cycloeucalenone + NADPH + H+ <=> cycloeucalenol + NADP. [GOC:pz, PMID:4387005]"}
{"concept_id": "C4236475", "aliases": [], "types": ["T044"], "canonical_name": "pyocyanin hydroxylase activity", "definition": "Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ = pyocyanin + NAD + carbon dioxide + H2O. [GOC:pz, PMID:11591691]"}
{"concept_id": "C4236476", "aliases": [], "types": ["T044"], "canonical_name": "copal-8-ol diphosphate synthase activity", "definition": "Catalysis of the reaction: copal-8-ol diphosphate <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O. [EC:4.2.1.133, GOC:pz]"}
{"concept_id": "C4236477", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate <=> H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP. [EC:2.4.1.254, GOC:pz]"}
{"concept_id": "C4236478", "aliases": [], "types": ["T044"], "canonical_name": "baicalein 7-O-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein <=> H+ + UDP + baicalin. [EC:2.4.1.253, GOC:pz]"}
{"concept_id": "C4236479", "aliases": [], "types": ["T044"], "canonical_name": "7-oxatyphasterol synthase activity", "definition": "Catalysis of the reaction: H+ + typhasterol + NADPH + O2 <=> 7-oxatyphasterol + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4236480", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A20 carboxyl methyltransferase activity", "definition": "Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4236481", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A4 carboxyl methyltransferase activity", "definition": "Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine <=> gibberellin A4 methyl ester + S-adenosyl-L-homocysteine. [EC:2.1.1.276, GOC:pz]"}
{"concept_id": "C4236482", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A9 carboxyl methyltransferase activity", "definition": "Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine <=> gibberellin A9 methyl ester + S-adenosyl-L-homocysteine. [EC:2.1.1.275, GOC:pz]"}
{"concept_id": "C4236483", "aliases": [], "types": ["T044"], "canonical_name": "3,4-dichlorobenzoate-4,5-oxygenase activity", "definition": "Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor. [GOC:pz, PMID:9322760]"}
{"concept_id": "C4236484", "aliases": [], "types": ["T044"], "canonical_name": "3-chlorobenzoate-3,4-oxygenase activity", "definition": "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor. [GOC:pz, PMID:8285670]"}
{"concept_id": "C4236485", "aliases": [], "types": ["T044"], "canonical_name": "3-chlorobenzoate-4,5-oxygenase activity", "definition": "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4236486", "aliases": [], "types": ["T044"], "canonical_name": "4-nitrotoluene monooxygenase activity", "definition": "Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O. [GOC:pz]"}
{"concept_id": "C4236487", "aliases": [], "types": ["T044"], "canonical_name": "methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity", "definition": "Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]. [EC:2.1.1.258, GOC:pz, PMID:7928975]"}
{"concept_id": "C4236488", "aliases": [], "types": ["T044"], "canonical_name": "isobutyryl-CoA:FAD oxidoreductase activity", "definition": "Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2. [GOC:pz, PMID:3988734]"}
{"concept_id": "C4236489", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 fatty acid omega-hydroxylase activity"}
{"concept_id": "C4236490", "aliases": [], "types": ["T044"], "canonical_name": "4-acetamido-4,6-dideoxy-D-galactose transferase activity", "definition": "Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol <=> H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP. [EC:2.4.1.325, GOC:pz]"}
{"concept_id": "C4236491", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity", "definition": "Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine. [GOC:pz, RHEA:30063]"}
{"concept_id": "C4236492", "aliases": [], "types": ["T044"], "canonical_name": "arginine-importing ATPase activity"}
{"concept_id": "C4236493", "aliases": ["alkylphosphonate transmembrane-transporting ATPase activity", "ATPase-coupled alkylphosphonate transmembrane transporter activity"], "types": ["T044"], "canonical_name": "alkylphosphonate ABC transporter activity"}
{"concept_id": "C4236494", "aliases": [], "types": ["T044"], "canonical_name": "beta-D-galactose-importing ATPase activity", "definition": "Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O <=> ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+. [EC:3.6.3.17]"}
{"concept_id": "C4236495", "aliases": [], "types": ["T044"], "canonical_name": "L-glutamate-importing ATPase activity"}
{"concept_id": "C4236497", "aliases": [], "types": ["T044"], "canonical_name": "acyl-L-homoserine-lactone lactonohydrolase activity", "definition": "Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine. [EC:3.1.1.81]"}
{"concept_id": "C4236498", "aliases": [], "types": ["T044"], "canonical_name": "4-methyl-2-oxopentanoate dehydrogenase activity", "definition": "Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) <=> isovaleryl-CoA(4-) + carbon dioxide + NADH(2-). [EC:1.2.1.-]"}
{"concept_id": "C4236499", "aliases": [], "types": ["T044"], "canonical_name": "2-octaprenyl-6-hydroxyphenol methylase activity", "definition": "Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine. [EC:2.1.1.222]"}
{"concept_id": "C4236500", "aliases": [], "types": ["T044"], "canonical_name": "Delta8-sphingolipid desaturase activity", "definition": "Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor <=> 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.4]"}
{"concept_id": "C4236501", "aliases": [], "types": ["T044"], "canonical_name": "valine N-monooxygenase (oxime forming) activity", "definition": "Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O. [EC:1.14.14.38]"}
{"concept_id": "C4236502", "aliases": [], "types": ["T044"], "canonical_name": "isoleucine N-monooxygenase (oxime forming) activity", "definition": "Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O. [EC:1.14.14.39]"}
{"concept_id": "C4236503", "aliases": [], "types": ["T044"], "canonical_name": "FMN-binding domain binding", "definition": "Binding to the FMN-binding domain of a protein. [PMID:15752726]"}
{"concept_id": "C4236504", "aliases": ["mechanically-modulated voltage-gated sodium channel activity"], "types": ["T044"], "canonical_name": "mechanosensitive voltage-gated sodium channel activity", "definition": "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [PMID:21041530, PMID:26838316]"}
{"concept_id": "C4236505", "aliases": ["inositol 1-pyrophosphate 2,3,4,5,6-pentakisphosphate 1-pyrophosphatase activity"], "types": ["T044"], "canonical_name": "inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity", "definition": "Catalysis of the reaction: myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = myo-inositol hexakisphosphate + phosphate. [GOC:mah, PMID:26422458]"}
{"concept_id": "C4236506", "aliases": [], "types": ["T042"], "canonical_name": "pulmonary blood vessel remodeling", "definition": "The reorganization or renovation of existing pulmonary blood vessels. [GOC:mec]"}
{"concept_id": "C4236509", "aliases": [], "types": ["T044"], "canonical_name": "protein histidine phosphatase activity", "definition": "Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. [GOC:mec, RHEA:47964]"}
{"concept_id": "C4236510", "aliases": [], "types": ["T026"], "canonical_name": "cytolytic granule membrane", "definition": "The lipid bilayer surrounding the cytolytic granule. [PMID:17272266, PMID:21247065]"}
{"concept_id": "C4236511", "aliases": [], "types": ["T026"], "canonical_name": "ficolin-1-rich granule membrane", "definition": "The lipid bilayer surrounding a ficolin-1-rich granule. [GOC:mec, PMID:23650620]"}
{"concept_id": "C4236512", "aliases": ["ficolin-1 rich granule"], "types": ["T026"], "canonical_name": "ficolin-1-rich granule", "definition": "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry. [GOC:mec, PMID:19741154]"}
{"concept_id": "C4236513", "aliases": ["perimembrane region"], "types": ["T026"], "canonical_name": "cell cortex region", "definition": "The complete extent of cell cortex that underlies some some region of the plasma membrane. [GOC:dos]"}
{"concept_id": "C4236514", "aliases": [], "types": ["T043"], "canonical_name": "induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration", "definition": "The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission. [GOC:dos, ISBN:9780071120005]"}
{"concept_id": "C4236515", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter receptor transport, plasma membrane to endosome", "definition": "Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome. [GOC:dos]"}
{"concept_id": "C4236516", "aliases": ["neurotransmitter receptor localisation in postsynaptic specialization membrane"], "types": ["T043"], "canonical_name": "neurotransmitter receptor localization to postsynaptic specialization membrane", "definition": "A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). [GOC:dos]"}
{"concept_id": "C4236517", "aliases": ["protein localisation to presynaptic membrane", "protein localisation in presynaptic membrane", "protein localization in presynaptic membrane"], "types": ["T043"], "canonical_name": "protein localization to presynaptic membrane", "definition": "A process in which a protein is transported to, or maintained in, a location within a presynaptic membrane. [GOC:dos]"}
{"concept_id": "C4236518", "aliases": [], "types": ["T039"], "canonical_name": "signal release from synapse", "definition": "Any signal release from a synapse. [GOC:dos]"}
{"concept_id": "C4236519", "aliases": [], "types": ["T043"], "canonical_name": "axo-dendritic protein transport", "definition": "The directed movement of proteins along microtubules in neuron projections. [ISBN:0815316194]"}
{"concept_id": "C4236520", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter receptor transport, endosome to plasma membrane", "definition": "The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles. [GOC:dos]"}
{"concept_id": "C4236521", "aliases": [], "types": ["T043"], "canonical_name": "endosome to plasma membrane protein transport", "definition": "The directed movement of proteins from the endosome to the plasma membrane in transport vesicles. [GOC:dos]"}
{"concept_id": "C4236522", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter receptor transport", "definition": "The directed movement of neurotransmitter receptors. [GOC:dos]"}
{"concept_id": "C4236523", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels", "definition": "Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission. [GOC:dos]"}
{"concept_id": "C4236524", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic specialization membrane", "definition": "The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]"}
{"concept_id": "C4236525", "aliases": ["protein localisation in postsynaptic specialization membrane"], "types": ["T043"], "canonical_name": "protein localization to postsynaptic specialization membrane", "definition": "A process in which a protein is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. post synaptic density). [GOC:dos]"}
{"concept_id": "C4236526", "aliases": [], "types": ["T043"], "canonical_name": "protein transport within plasma membrane", "definition": "A process in which protein is transported from one region of the plasma membrane to another. [GOC:dos]"}
{"concept_id": "C4236527", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic endocytic zone cytoplasmic component", "definition": "The cytoplasmic component of the postsynaptic endocytic zone. [GOC:dos]"}
{"concept_id": "C4236528", "aliases": [], "types": ["T043"], "canonical_name": "postsynaptic neurotransmitter receptor cycle", "definition": "The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane. [PMID:18832033]"}
{"concept_id": "C4236529", "aliases": ["postsynaptic density of inhibitory synapse"], "types": ["T026"], "canonical_name": "postsynaptic specialization of symmetric synapse", "definition": "A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses. [PMID:18832033]"}
{"concept_id": "C4236530", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter receptor diffusion trapping", "definition": "The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane. [PMID:18832033]"}
{"concept_id": "C4236531", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter receptor cycle", "definition": "The process during which neurotransmitter receptors, anchored in some region of the synaptic membrane, are recycled via the endosome. This cycle includes release from anchoring, diffusion in the synaptic membrane to an endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent anchoring (trapping). [GOC:dos]"}
{"concept_id": "C4236532", "aliases": ["voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels"], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels", "definition": "Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels. [GOC:dos, PMID:15548655]"}
{"concept_id": "C4236533", "aliases": [], "types": ["T043"], "canonical_name": "ventricular cardiac muscle cell membrane repolarization", "definition": "The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C4236534", "aliases": [], "types": ["T043"], "canonical_name": "atrial cardiac muscle cell membrane repolarization", "definition": "The process in which ions are transported across the plasma membrane of an atrial cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF]"}
{"concept_id": "C4236535", "aliases": ["regulation of cardiomyocyte membrane repolarization", "regulation of cardiac muscle cell repolarization"], "types": ["T043"], "canonical_name": "regulation of cardiac muscle cell membrane repolarization", "definition": "Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. [GOC:BHF, GOC:dos, GOC:rl]"}
{"concept_id": "C4236536", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscle cell membrane repolarization", "definition": "The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF]"}
{"concept_id": "C4236537", "aliases": ["Ara4FN transferase activity", "undecaprenyl phosphate-L-Ara4FN transferase activity", "undecaprenyl-phosphate Ara4FN transferase activity"], "types": ["T044"], "canonical_name": "undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity", "definition": "Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate. [GOC:al, GOC:dos, PMID:11706007, PMID:15695810]"}
{"concept_id": "C4236538", "aliases": ["UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase", "UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase", "UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase", "UDP-L-Ara4N transaminase", "UDP-Ara4O aminotransferase"], "types": ["T044"], "canonical_name": "UDP-4-amino-4-deoxy-L-arabinose aminotransferase", "definition": "Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate. [GOC:al, GOC:dos, PMID:12429098, PMID:12704196]"}
{"concept_id": "C4236539", "aliases": ["ArnAFT activity", "UDP-L-Ara4N formyltransferase activity", "10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase activity"], "types": ["T044"], "canonical_name": "UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity", "definition": "Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. [PMID:15695810, PMID:15807526, PMID:15809294, PMID:15939024, PMID:17928292]"}
{"concept_id": "C4236540", "aliases": ["UDP-GlcUA decarboxylase activity"], "types": ["T044"], "canonical_name": "UDP-glucuronic acid dehydrogenase activity", "definition": "Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+. [GOC:al, GOC:dos]"}
{"concept_id": "C4236541", "aliases": [], "types": ["T026"], "canonical_name": "matrix side of mitochondrial inner membrane", "definition": "The side (leaflet) of the mitochondrial inner membrane that faces the matrix. [GOC:dos]"}
{"concept_id": "C4236542", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of matrix side of mitochondrial inner membrane", "definition": "The component of the matrix side of the mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]"}
{"concept_id": "C4236543", "aliases": ["R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity", "D-2HG-pyruvate transhydrogenase activity"], "types": ["T044"], "canonical_name": "(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity", "definition": "Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor. [PMID:26774271]"}
{"concept_id": "C4236544", "aliases": [], "types": ["T044"], "canonical_name": "protein targeting to spore cell wall"}
{"concept_id": "C4236545", "aliases": [], "types": ["T044"], "canonical_name": "protein localization to cell wall", "definition": "The process of directing proteins towards the cell-wall. [ISBN:0716731363]"}
{"concept_id": "C4236546", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to axon", "definition": "A process in which a protein is transported to or maintained in a location within an axon. [GOC:dos, PMID:26157139]"}
{"concept_id": "C4236547", "aliases": [], "types": ["T038"], "canonical_name": "regulation of action potential firing threshold", "definition": "Any process that regulates the potential at which an axon potential is triggered. [ISBN:978-0071390118]"}
{"concept_id": "C4236548", "aliases": ["action potential firing", "action potential triggering"], "types": ["T043"], "canonical_name": "action potential initiation", "definition": "The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate. [ISBN:978-0071390118, PMID:19439602]"}
{"concept_id": "C4236549", "aliases": [], "types": ["T044"], "canonical_name": "microtubule lateral binding", "definition": "Binding to the side of a microtubule. [GOC:dos]"}
{"concept_id": "C4236550", "aliases": ["spike train sculpting"], "types": ["T043"], "canonical_name": "regulation of action potential firing pattern", "definition": "Any process that regulates the temporal pattern of a sequence of action potentials in a neuron. [ISBN:978-0071390118]"}
{"concept_id": "C4236551", "aliases": [], "types": ["T043"], "canonical_name": "lateral attachment of mitotic spindle microtubules to kinetochore", "definition": "The cell cycle process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate). [PMID:26258632, PMID:26705896]"}
{"concept_id": "C4236552", "aliases": ["plus-end directed chromosome gliding"], "types": ["T043"], "canonical_name": "microtubule plus-end directed mitotic chromosome migration", "definition": "The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression. [GOC:dos, PMID:26258632, PMID:26705896]"}
{"concept_id": "C4236553", "aliases": [], "types": ["T038"], "canonical_name": "regulation of action potential firing rate", "definition": "Any process that regulates the frequency of action potentials in a spike train. [ISBN:978-0071390118]"}
{"concept_id": "C4236554", "aliases": [], "types": ["T044"], "canonical_name": "ligand-gated calcium channel activity", "definition": "Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:dos]"}
{"concept_id": "C4236555", "aliases": [], "types": ["T044"], "canonical_name": "neurotransmitter receptor regulator activity", "definition": "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing. [GOC:dos, PMID:12740117, PMID:18387948]"}
{"concept_id": "C4236556", "aliases": [], "types": ["T039"], "canonical_name": "regulation of neurotransmitter receptor activity", "definition": "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. [GOC:dos]"}
{"concept_id": "C4236557", "aliases": [], "types": ["T043"], "canonical_name": "endocytosed synaptic vesicle to endosome fusion", "definition": "Fusion of an endocytosed synaptic vesicle with an endosome. [GOC:dos]"}
{"concept_id": "C4236558", "aliases": ["synaptic vesicle processing via endosome involved in synaptic vesicle recycling"], "types": ["T043"], "canonical_name": "endocytosed synaptic vesicle processing via endosome", "definition": "The process in which endocytosed synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles. [GOC:dos]"}
{"concept_id": "C4236559", "aliases": ["postsynaptic neurotransmitter receptor endocytosis", "postsynaptic neurotransmitter receptor internalization"], "types": ["T043"], "canonical_name": "neurotransmitter receptor internalization", "definition": "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor. [GOC:dos]"}
{"concept_id": "C4236560", "aliases": [], "types": ["T044"], "canonical_name": "serotonin receptor activity", "definition": "Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:dos]"}
{"concept_id": "C4236561", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of postsynaptic cytosolic calcium concentration", "definition": "Any process that increases the concentration of calcium ions in the postsynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4236562", "aliases": [], "types": ["T043"], "canonical_name": "release of sequestered calcium ion into postsynaptic cytosol", "definition": "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4236563", "aliases": [], "types": ["T043"], "canonical_name": "release of sequestered calcium ion into presynaptic cytosol", "definition": "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4236564", "aliases": ["neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels"], "types": ["T044"], "canonical_name": "neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "definition": "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4236565", "aliases": ["neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels"], "types": ["T044"], "canonical_name": "neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration", "definition": "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4236566", "aliases": ["ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential", "ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential"], "types": ["T044"], "canonical_name": "ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential", "definition": "Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential. [GOC:dos]"}
{"concept_id": "C4236567", "aliases": ["ion antiporter activity involved in regulation of post-synaptic membrane potential"], "types": ["T044"], "canonical_name": "ion antiporter activity involved in regulation of postsynaptic membrane potential", "definition": "Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential. [GOC:dos]"}
{"concept_id": "C4236568", "aliases": ["G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential"], "types": ["T044"], "canonical_name": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "definition": "A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential. [GOC:dos]"}
{"concept_id": "C4236569", "aliases": [], "types": ["T043"], "canonical_name": "regulation of translation at postsynapse, modulating synaptic transmission", "definition": "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. [GOC:dos]"}
{"concept_id": "C4236570", "aliases": [], "types": ["T043"], "canonical_name": "regulation of translation at presynapse, modulating synaptic transmission", "definition": "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. [GOC:dos]"}
{"concept_id": "C4236571", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein catabolic process at postsynapse, modulating synaptic transmission", "definition": "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. [GOC:dos]"}
{"concept_id": "C4236572", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein catabolic process at presynapse, modulating synaptic transmission", "definition": "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. [GOC:dos]"}
{"concept_id": "C4236573", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein catabolic process at synapse, modulating synaptic transmission", "definition": "Any process that modulates synaptic transmission by regulating protein degradation at the synapse. [GOC:dos]"}
{"concept_id": "C4236574", "aliases": ["postsynaptic specialization, glutamatergic neuron-to-neuron synapse"], "types": ["T026"], "canonical_name": "glutamatergic postsynaptic density", "definition": "The post-synaptic specialization of a glutamatergic excitatory synapse. [GOC:dos]"}
{"concept_id": "C4236575", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic specialization", "definition": "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [PMID:22046028]"}
{"concept_id": "C4236576", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic cytoskeleton", "definition": "The portion of the cytoskeleton contained within the postsynapse. [GOC:dos, PMID:19889835]"}
{"concept_id": "C4236577", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic cytoskeleton", "definition": "The portion of the cytoskeleton contained within the presynapse. [GOC:dos]"}
{"concept_id": "C4236578", "aliases": ["calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels", "postsynaptic calcium ion buffering"], "types": ["T044"], "canonical_name": "calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration", "definition": "The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations. [PMID:24442513, PMID:26190970]"}
{"concept_id": "C4236579", "aliases": ["regulation of postsynaptic cytosolic calcium levels"], "types": ["T043"], "canonical_name": "regulation of postsynaptic cytosolic calcium ion concentration", "definition": "Any process that regulates the concentration of calcium in the postsynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4236580", "aliases": [], "types": ["T044"], "canonical_name": "chemical synaptic transmission, postsynaptic", "definition": "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4236581", "aliases": [], "types": ["T043"], "canonical_name": "modification of synaptic structure, modulating synaptic transmission", "definition": "Any process that modulates synaptic transmission via modification of the structure of the synapse. [GOC:dos]"}
{"concept_id": "C4236582", "aliases": ["modification of synaptic structure"], "types": ["T043"], "definition": "Any process that modifies the structure/morphology of a synapse. [GOC:dos]", "canonical_name": "synapse remodelling"}
{"concept_id": "C4236583", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of postsynaptic density structure", "definition": "A process which maintains the organization and the arrangement of proteins in the presynaptic density. [GOC:dos]"}
{"concept_id": "C4236584", "aliases": [], "types": ["T043"], "canonical_name": "synaptic membrane adhesion to extracellular matrix", "definition": "The binding of a synaptic membrane to the extracellular matrix via adhesion molecules. [GOC:dos]"}
{"concept_id": "C4236585", "aliases": ["synapse adhesion between pre- and post-synapse"], "types": ["T043"], "canonical_name": "synaptic membrane adhesion", "definition": "The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. [GOC:dos]"}
{"concept_id": "C4236586", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of alignment of postsynaptic density and presynaptic active zone", "definition": "The process by which alignment between postsynaptic density and presynaptic active zone is maintained. [GOC:dos]"}
{"concept_id": "C4236587", "aliases": ["synaptic maintenance"], "types": ["T043"], "canonical_name": "maintenance of synapse structure", "definition": "A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. [GOC:dos, PMID:24449494, PMID:25611509]"}
{"concept_id": "C4236588", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission", "definition": "Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse. [GOC:dos, PMID:19029886]"}
{"concept_id": "C4236589", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by carbon monoxide, modulating synaptic transmission", "definition": "Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse. [GOC:dos]"}
{"concept_id": "C4236590", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by nitric oxide, modulating synaptic transmission", "definition": "Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse. [GOC:dos]"}
{"concept_id": "C4236591", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by soluble gas, modulating synaptic transmission", "definition": "Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse. [GOC:dos]"}
{"concept_id": "C4236592", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by endocannabinoid, modulating synaptic transmission", "definition": "Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse. [GOC:dos, PMID:21531987]"}
{"concept_id": "C4236593", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by lipid, modulating synaptic transmission", "definition": "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. [GOC:dos, PMID:21531987]"}
{"concept_id": "C4236594", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by neuropeptide, modulating synaptic transmission", "definition": "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. [GOC:dos]"}
{"concept_id": "C4236595", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling, modulating synaptic transmission", "definition": "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. [GOC:dos]"}
{"concept_id": "C4236596", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by carbon monoxide", "definition": "Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide. [GOC:dos]"}
{"concept_id": "C4236597", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by nitric oxide", "definition": "Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide. [GOC:dos]"}
{"concept_id": "C4236598", "aliases": [], "types": ["T043"], "canonical_name": "regulation of translation at synapse, modulating synaptic transmission", "definition": "Any process that modulates synaptic transmission by regulating translation occurring at the synapse. [GOC:dos]"}
{"concept_id": "C4236599", "aliases": [], "types": ["T044"], "canonical_name": "protein catabolic process, modulating synaptic transmission", "definition": "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. [GOC:dos, PMID:23083742]"}
{"concept_id": "C4236600", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by trans-synaptic complex", "definition": "Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex. [GOC:dos]"}
{"concept_id": "C4236601", "aliases": ["extrasynaptic space"], "types": ["T026"], "canonical_name": "perisynaptic space", "definition": "The extracellular region immediately adjacent to to a synapse. [GOC:dos]"}
{"concept_id": "C4236602", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by soluble gas", "definition": "Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft. [GOC:dos]"}
{"concept_id": "C4236603", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by endocannabinoid", "definition": "Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand. [GOC:dos]"}
{"concept_id": "C4236604", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by lipid", "definition": "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. [GOC:dos]"}
{"concept_id": "C4236605", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by neuropeptide", "definition": "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. [GOC:dos]"}
{"concept_id": "C4236606", "aliases": ["neuropeptide secretion from presynapse via dense core granule exocytosis"], "types": ["T043"], "canonical_name": "neuropeptide secretion from presynapse", "definition": "The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration. [PMID:17553987, PMID:24653208]"}
{"concept_id": "C4236607", "aliases": [], "types": ["T043"], "canonical_name": "synaptic signaling via neuropeptide", "definition": "Cell-cell signaling to or from a synapse, mediated by a peptide. [GOC:dos]"}
{"concept_id": "C4236608", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling", "definition": "Cell-cell signaling in either direction across the synaptic cleft. [GOC:dos]"}
{"concept_id": "C4236609", "aliases": [], "types": ["T043"], "canonical_name": "synaptic signaling", "definition": "Cell-cell signaling to, from or within a synapse. [GOC:dos]"}
{"concept_id": "C4236610", "aliases": ["extra-synaptic extracellular matrix"], "types": ["T026"], "definition": "The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. [GOC:dos]", "canonical_name": "synapse-associated extracellular matrix"}
{"concept_id": "C4236611", "aliases": ["calcium ion binding involved in regulation of presynaptic cytosolic calcium levels", "regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering", "presynaptic calcium ion buffering"], "types": ["T044"], "canonical_name": "calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "definition": "The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations. [PMID:24442513, PMID:26190970]"}
{"concept_id": "C4236612", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of presynaptic cytosolic calcium concentration", "definition": "Any process that increases the concentration of calcium ions in the presynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4236613", "aliases": ["synaptic vesicle processing via endosome"], "types": ["T043"], "canonical_name": "synaptic vesicle endosomal processing", "definition": "The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles. [GOC:aruk, GOC:bc, GOC:dos]"}
{"concept_id": "C4236614", "aliases": [], "types": ["T038"], "canonical_name": "presynaptic process involved in chemical synaptic transmission", "definition": "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. [GOC:dos]"}
{"concept_id": "C4236615", "aliases": ["G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential"], "types": ["T044"], "canonical_name": "G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential", "definition": "A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane. [GOC:dos]"}
{"concept_id": "C4236616", "aliases": [], "types": ["T044"], "canonical_name": "neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "definition": "Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel). [GOC:dos]"}
{"concept_id": "C4236617", "aliases": ["G-protein coupled neurotransmitter receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled neurotransmitter receptor activity", "definition": "Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:fj, GOC:mah]"}
{"concept_id": "C4236618", "aliases": ["postsynaptic signaling to nucleus"], "types": ["T043"], "canonical_name": "postsynapse to nucleus signaling pathway", "definition": "The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). [GOC:dos, PMID:24317321, PMID:25652077]"}
{"concept_id": "C4236619", "aliases": ["presynaptic signaling to nucleus"], "types": ["T043"], "canonical_name": "presynapse to nucleus signaling pathway", "definition": "The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). [GOC:dos, PMID:24317321, PMID:25652077]"}
{"concept_id": "C4236620", "aliases": [], "types": ["T043"], "canonical_name": "presynaptic dense core vesicle exocytosis", "definition": "The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels. [PMID:17553987, PMID:24653208]"}
{"concept_id": "C4236621", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic cytosol", "definition": "The region of the cytosol consisting of all cytosol that is part of the postsynapse. [GOC:dos]"}
{"concept_id": "C4236622", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic cytosol", "definition": "The region of the cytosol consisting of all cytosol that is part of the presynapse. [GOC:dos]"}
{"concept_id": "C4236623", "aliases": ["region of cytosol"], "types": ["T026"], "canonical_name": "cytosolic region", "definition": "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol. [GOC:dos]"}
{"concept_id": "C4236624", "aliases": ["ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential", "ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential"], "types": ["T044"], "canonical_name": "ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential", "definition": "Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. [GOC:dos, PMID:17220883]"}
{"concept_id": "C4236625", "aliases": ["ion antiporter activity involved in regulation of pre-synaptic membrane potential"], "types": ["T043"], "canonical_name": "ion antiporter activity involved in regulation of presynaptic membrane potential", "definition": "Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. [GOC:dos]"}
{"concept_id": "C4236626", "aliases": ["dense core vesicle cytoskeletal trafficking"], "types": ["T043"], "canonical_name": "dense core granule cytoskeletal transport", "definition": "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments. [GOC:kmv, PMID:23358451]"}
{"concept_id": "C4236627", "aliases": ["vesicle cytoskeletal transport", "cytoskeletal fiber-based vesicle localization"], "types": ["T043"], "canonical_name": "vesicle cytoskeletal trafficking", "definition": "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. [GOC:ecd, GOC:rl]"}
{"concept_id": "C4236628", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle transport along microtubule", "definition": "The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. [GOC:dos]"}
{"concept_id": "C4236629", "aliases": [], "types": ["T044"], "canonical_name": "ion antiporter activity"}
{"concept_id": "C4236630", "aliases": [], "types": ["T043"], "canonical_name": "actin filament-based transport", "definition": "The transport of organelles or other particles from one location in the cell to another along actin filaments. [GOC:dos, GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C4236631", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle cytoskeletal transport", "definition": "The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. [GOC:dos]"}
{"concept_id": "C4236632", "aliases": [], "types": ["T026"], "canonical_name": "polymeric cytoskeletal fiber", "definition": "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. [GOC:dos]"}
{"concept_id": "C4236633", "aliases": ["supramolecular fiber"], "types": ["T026"], "definition": "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. [GOC:dos]", "canonical_name": "fibril"}
{"concept_id": "C4236634", "aliases": [], "types": ["T044"], "canonical_name": "voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels", "definition": "Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel. [GOC:dos]"}
{"concept_id": "C4236635", "aliases": ["regulation of cytosolic calcium ion concentration by calcium ion buffering"], "types": ["T044"], "canonical_name": "calcium ion binding involved in regulation of cytosolic calcium ion concentration", "definition": "The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations. [PMID:24442513, PMID:26190970]"}
{"concept_id": "C4236636", "aliases": ["regulation of presynaptic cytosolic calcium levels"], "types": ["T043"], "canonical_name": "regulation of presynaptic cytosolic calcium ion concentration", "definition": "Any process that regulates the concentration of calcium in the presynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4236637", "aliases": ["voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential", "voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential", "voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential", "voltage gated ion channel activity involved in regulation of presynaptic membrane potential"], "types": ["T044"], "canonical_name": "voltage-gated ion channel activity involved in regulation of presynaptic membrane potential", "definition": "Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. [GOC:dos]"}
{"concept_id": "C4236638", "aliases": ["ligand gated ion channel activity involved in regulation of presynaptic membrane potential", "ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential", "ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential", "ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential"], "types": ["T044"], "canonical_name": "ligand-gated ion channel activity involved in regulation of presynaptic membrane potential", "definition": "Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. [GOC:dos, PMID:15145529, PMID:19558451]"}
{"concept_id": "C4236639", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle transport along actin filament", "definition": "The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors. [GOC:dos]"}
{"concept_id": "C4236640", "aliases": ["regulation of pre-synaptic membrane potential"], "types": ["T043"], "canonical_name": "regulation of presynaptic membrane potential", "definition": "Any process that modulates the potential difference across a presynaptic membrane. [GOC:dph, GOC:ef]"}
{"concept_id": "C4236641", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle cycle", "definition": "A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. [GOC:aruk, GOC:bc, PMID:15217342]"}
{"concept_id": "C4236642", "aliases": [], "types": ["T043"], "canonical_name": "calcium-dependent activation of synaptic vesicle fusion", "definition": "The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane. [PMID:23060190]"}
{"concept_id": "C4236643", "aliases": [], "types": ["T026"], "canonical_name": "exocytic vesicle membrane", "definition": "The lipid bilayer surrounding an exocytic vesicle. [GOC:dos]"}
{"concept_id": "C4236644", "aliases": [], "types": ["T043"], "canonical_name": "vesicle fusion to plasma membrane", "definition": "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]"}
{"concept_id": "C4236645", "aliases": ["mitotic sister chromatid cohesion at telomere", "sister chromatid cohesion at telomere at mitosis", "telomeric mitotic sister chromatin cohesion"], "types": ["T043"], "canonical_name": "mitotic sister chromatid cohesion, telomeric", "definition": "The cell cycle process in which telomeres of sister chromatids are joined during mitosis. [GOC:BHF, GOC:BHF_telomere, GOC:mah, GOC:rph, PMID:26373281]"}
{"concept_id": "C4236646", "aliases": ["maintenance of telomeric mitotic sister chromatin cohesion", "maintenance of sister chromatin cohesion at telomere at mitosis", "maintenance of mitotic sister chromatin cohesion at telomere"], "types": ["T043"], "canonical_name": "maintenance of mitotic sister chromatid cohesion, telomeric", "definition": "The process in which the association between sister chromatids of a replicated chromosome along the length of the telomeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. [GOC:BHF, GOC:BHF_telomere, GOC:dos, GOC:rph, PMID:26373281]"}
{"concept_id": "C4236647", "aliases": ["caveola crater"], "types": ["T026"], "canonical_name": "caveola bulb", "definition": "The region of a caveola that extends into the cytoplasm, excluding the neck (rim). This region is associated with intracellular caveola proteins. [GOC:PARL, GOC:POD, PMID:17227843]"}
{"concept_id": "C4236648", "aliases": [], "types": ["T026"], "canonical_name": "caveola neck", "definition": "A membrane microdomain that forms a necklace around the bulb (crater) of a caveola. Intramembrane particles are concentrated in this region and cytoskeletal components, including actin, are highly enriched in the area underlying it. [GOC:pad, GOC:PARL, PMID:17227843]"}
{"concept_id": "C4236649", "aliases": [], "types": ["T043"], "canonical_name": "retrograde trans-synaptic signaling by trans-synaptic protein complex", "definition": "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex. [GOC:dos]"}
{"concept_id": "C4236650", "aliases": [], "types": ["T043"], "canonical_name": "anterograde trans-synaptic signaling by trans-synaptic protein complex", "definition": "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex. [GOC:dos]"}
{"concept_id": "C4236651", "aliases": [], "types": ["T043"], "canonical_name": "anterograde trans-synaptic signaling by nitric oxide", "definition": "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide. [GOC:dos]"}
{"concept_id": "C4236652", "aliases": [], "types": ["T026"], "canonical_name": "actin cytoskeleton of dendritic spine", "definition": "The actin cytoskeleton that is part of a dendritic spine. [GOC:dos]"}
{"concept_id": "C4236653", "aliases": ["degradation of host cell wall peptidoglycan by virus", "degradation of host peptidoglycans during virus entry", "catabolism of host cell wall peptidoglycan by virus", "disassembly by virus of host cell wall peptidoglycan"], "types": ["T040"], "canonical_name": "disruption by virus of host cell wall peptidoglycan during virus entry", "definition": "A process carried out by a virus that breaks down peptidoglycans in the cell wall of its host during viral entry. [GOC:dos, VZ:3940]"}
{"concept_id": "C4236654", "aliases": [], "types": ["T043"], "canonical_name": "virion attachment to host cell flagellum", "definition": "The process by which a virion attaches to a the host cell flagellum. Some DNA bacterial viruses use flagella to attach to the host cell. This contact with the flagellum facilitates concentration of phage particles around the entry receptor on the bacterial cell surface. [GOC:dos, VZ:3949]"}
{"concept_id": "C4236655", "aliases": ["presynaptic signaling pathway"], "types": ["T043"], "canonical_name": "presynaptic signal transduction", "definition": "Signal transduction in which the initial step occurs in a presynapse. [GOC:dos]"}
{"concept_id": "C4236656", "aliases": [], "types": ["T043"], "canonical_name": "vesicle-mediated transport between endosomal compartments", "definition": "A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. [GOC:dos, PMID:10930469]"}
{"concept_id": "C4236657", "aliases": ["postsynaptic signaling pathway"], "types": ["T043"], "canonical_name": "postsynaptic signal transduction", "definition": "Signal transduction in which the initial step occurs in a postsynapse. [GOC:dos]"}
{"concept_id": "C4236658", "aliases": [], "types": ["T043"], "canonical_name": "retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission", "definition": "Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. [GOC:dos]"}
{"concept_id": "C4236659", "aliases": [], "types": ["T043"], "canonical_name": "retrograde trans-synaptic signaling by nitric oxide", "definition": "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. [GOC:dos]"}
{"concept_id": "C4236660", "aliases": [], "types": ["T043"], "canonical_name": "retrograde trans-synaptic signaling by soluble gas", "definition": "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand. [GOC:dos]"}
{"concept_id": "C4236661", "aliases": [], "types": ["T043"], "canonical_name": "retrograde trans-synaptic signaling by endocannabinoid", "definition": "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand. [GOC:dos]"}
{"concept_id": "C4236662", "aliases": [], "types": ["T043"], "canonical_name": "retrograde trans-synaptic signaling by lipid", "definition": "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. [GOC:dos]"}
{"concept_id": "C4236663", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of postsynaptic density", "definition": "The action of a molecule that contributes to the structural integrity of a postsynaptic density. [GOC:dos]"}
{"concept_id": "C4236664", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of synapse", "definition": "The action of a molecule that contributes to the structural integrity of a synapse. [GOC:dos]"}
{"concept_id": "C4236665", "aliases": [], "types": ["T043"], "canonical_name": "retrograde trans-synaptic signaling", "definition": "Cell-cell signaling from post to pre-synapse, across the synaptic cleft. [GOC:dos]"}
{"concept_id": "C4236666", "aliases": [], "types": ["T043"], "canonical_name": "anterograde trans-synaptic signaling", "definition": "Cell-cell signaling from pre to post-synapse, across the synaptic cleft. [GOC:dos]"}
{"concept_id": "C4236667", "aliases": [], "types": ["T026"], "canonical_name": "epididymosome", "definition": "A microvesicle of the epididymal fluid, from which spermatozoa aquire membrane proteins. [GOC:dos, GOC:mg, PMID:23177142, PMID:26112475]"}
{"concept_id": "C4236668", "aliases": ["spike-train", "burst of action potentials"], "types": ["T043"], "canonical_name": "spike train", "definition": "A series of sequential, propagated action potentials occurring in a single cell. [ISBN:978-0071390118]"}
{"concept_id": "C4236669", "aliases": [], "types": ["T043"], "canonical_name": "neuronal action potential back-propagation", "definition": "Propagation of an action potential in a neuron, from its site of initiation (typically the axon hillock) towards the soma. [GOC:dos]"}
{"concept_id": "C4236670", "aliases": ["G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels"], "types": ["T044"], "canonical_name": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "definition": "A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse. [GOC:dos]"}
{"concept_id": "C4236671", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic actin cytoskeleton", "definition": "The actin cytoskeleton that is part of a postsynapse. [GOC:dos]"}
{"concept_id": "C4236672", "aliases": [], "types": ["T043"], "canonical_name": "action potential propagation", "definition": "The propagation of an action potential along the plane of an excitable membrane. Action potentials typically propagate once triggered because the depolarization of adjacent membrane regions due to an action potential crosses the firing threshold. [GOC:dos]"}
{"concept_id": "C4236673", "aliases": [], "types": ["T043"], "canonical_name": "cellular oxidant detoxification", "definition": "Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. [GOC:dos, GOC:vw]"}
{"concept_id": "C4236674", "aliases": [], "types": ["T038"], "canonical_name": "intramembranous bone growth", "definition": "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone. [PMID:26399686]"}
{"concept_id": "C4236675", "aliases": [], "types": ["T043"], "canonical_name": "multivesicular body fusion to apical plasma membrane", "definition": "The fusion of the membrane of a multivesicular body with the apical plasma membrane, resulting in release of exosomes from the cell. [PMID:26459596]"}
{"concept_id": "C4236676", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host bicellular tight junctions", "definition": "The process in which an organism effects a change in the structure or function of its host bicellular tight junctions, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. [PMID:24287273]"}
{"concept_id": "C4236677", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host tight cell-cell junction", "definition": "The process in which a symbiont organism effects a change in the structure or function of its host tight junction, a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. [PMID:24287273]"}
{"concept_id": "C4236678", "aliases": [], "types": ["T043"], "canonical_name": "nuclear migration by microtubule mediated pushing forces", "definition": "The directed movement of the nucleus by pushing forces exerted by polymerization of backward-extending microtubules. [GOC:vw, PMID:11309419, PMID:16611238]"}
{"concept_id": "C4236679", "aliases": [], "types": ["T026"], "canonical_name": "cluster of actin-based cell projections", "definition": "A cell part consisting of multiple, closely packed actin-based cell projections. [GOC:dos]"}
{"concept_id": "C4236680", "aliases": [], "types": ["T026"], "canonical_name": "actin filament bundle of filopodium", "definition": "A parallel bundle of actin filaments that is part of filopodium. Filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex. [PMID:12566431]"}
{"concept_id": "C4236681", "aliases": [], "types": ["T026"], "canonical_name": "actin filament bundle of stereocilium", "definition": "A bundle of hundreds of cross-linked actin filaments (an actin cable), that is the supporting structure of a stereocilium. Filaments are oriented such that the the plus (barbed) ends are at the tip of the protrusion and are capped by a tip complex which bridges to the plasma membrane. [PMID:15661519]"}
{"concept_id": "C4236682", "aliases": [], "types": ["T026"], "canonical_name": "actin filament bundle of actin-based cell projection", "definition": "A bundle of cross-linked actin filaments that is part of an actin-based cell protrusion, in which filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which stabilizes the filaments. [PMID:12566431, PMID:15661519]"}
{"concept_id": "C4236683", "aliases": [], "types": ["T026"], "canonical_name": "actin-based cell projection", "definition": "A cell projection supported by an assembly of actin filaments, and which lacks microtubules. [PMID:15661519]"}
{"concept_id": "C4236684", "aliases": [], "types": ["T043"], "canonical_name": "intestinal lipid absorption", "definition": "Any process in which lipids are taken up from the contents of the intestine. [GOC:dos, GOC:sl, PMID:18768481]"}
{"concept_id": "C4236685", "aliases": ["podocyte major process", "primary podocyte process", "glomerular visceral epithelial cell primary projection"], "types": ["T026"], "canonical_name": "podocyte primary projection", "definition": "A cell projection originating from a renal glomerular podocyte and extending to the renal glomerular podocyte foot. [PMID:24309184, PMID:25324828]"}
{"concept_id": "C4236686", "aliases": ["ER-vacuole membrane contact site"], "types": ["T026"], "canonical_name": "endoplasmic reticulum-vacuole membrane contact site", "definition": "A zone of apposition between endoplasmic-reticulum and lytic vacuole membranes, structured by bridging complexes. [GOC:dos, PMID:26283797]"}
{"concept_id": "C4236687", "aliases": [], "types": ["T026"], "canonical_name": "lytic vacuole membrane", "definition": "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. [GOC:dos]"}
{"concept_id": "C4236688", "aliases": ["miRNA duplex binding"], "types": ["T045"], "canonical_name": "double-stranded miRNA binding", "definition": "Binding to double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19966796]"}
{"concept_id": "C4236689", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of synaptic vesicle membrane", "definition": "The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]"}
{"concept_id": "C4236690", "aliases": [], "types": ["T043"], "canonical_name": "cellular detoxification of cadmium ion", "definition": "Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration. [GOC:dos, GOC:vw]"}
{"concept_id": "C4236691", "aliases": ["alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming)"], "types": ["T044"], "canonical_name": "alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity", "definition": "Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane. [EC:4.7.1.1, GOC:dos, GOC:ik]"}
{"concept_id": "C4236692", "aliases": [], "types": ["T045"], "canonical_name": "sequence-specific single stranded DNA binding", "definition": "Binding to single-stranded DNA of a specific nucleotide composition. [PMID:9531483]"}
{"concept_id": "C4236693", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic endosome", "definition": "An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse. [PMID:20820847]"}
{"concept_id": "C4236694", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic endocytic zone membrane", "definition": "The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta. [PMID:17880892]"}
{"concept_id": "C4236695", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic endocytic zone", "definition": "A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins. [PMID:17880892]"}
{"concept_id": "C4236696", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic early endosome", "definition": "An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling. [PMID:19603039, PMID:20820847, PMID:24727350]"}
{"concept_id": "C4236697", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to cell division site after cytokinesis", "definition": "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis. [PMID:25411334]"}
{"concept_id": "C4236698", "aliases": ["microtubule-based protein transport"], "types": ["T043"], "canonical_name": "protein transport along microtubule", "definition": "The directed movement of a protein along a microtubule, mediated by motor proteins. [PMID:25987607]"}
{"concept_id": "C4236699", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic density membrane", "definition": "The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]"}
{"concept_id": "C4236700", "aliases": [], "types": ["T043"], "canonical_name": "reduced folate transmembrane transport"}
{"concept_id": "C4236701", "aliases": ["postsynaptic recycling outpost"], "types": ["T026"], "canonical_name": "postsynaptic recycling endosome", "definition": "A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation. [PMID:20820847]"}
{"concept_id": "C4236702", "aliases": [], "types": ["T026"], "canonical_name": "cytoskeleton of dendritic spine", "definition": "The portion of the cytoskeleton that lies within a dendritic spine. The actin component of this cytoskeleton is involved in spine head remodelling in response to postsynaptic signalling. [PMID:24854120]"}
{"concept_id": "C4236703", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic endocytic zone membrane", "definition": "The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release. [GOC:dos]"}
{"concept_id": "C4236704", "aliases": ["cortex of presynaptic endocytic zone"], "types": ["T026"], "canonical_name": "presynaptic endocytic zone cytoplasmic component", "definition": "The cytoplasmic component of the presynaptic endocytic zone. [GOC:dos]"}
{"concept_id": "C4236705", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic endocytic zone", "definition": "A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity. [PMID:17455288]"}
{"concept_id": "C4236706", "aliases": [], "types": ["T026"], "canonical_name": "peri-centrosomal recycling endosome", "definition": "A recycling endosome that is organized around the microtubule organizing center, close to the nucleus. This is the main recycling endosome of most cells. It receives input from the Golgi as well as recycled molecules from early endosomes. [PMID:19696797, PMID:20820847]"}
{"concept_id": "C4236707", "aliases": ["presynaptic zone cortex", "cortex of presynaptic active zone"], "types": ["T026"], "canonical_name": "presynaptic active zone cytoplasmic component", "definition": "A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles. [GOC:dos]"}
{"concept_id": "C4236708", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic endosome", "definition": "An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles. [PMID:20200227, PMID:25939282]"}
{"concept_id": "C4236709", "aliases": [], "types": ["T042"], "canonical_name": "intestinal folate absorption", "definition": "Uptake of folic into the blood by absorption from the small intestine. [GOC:BHF, GOC:dos, GOC:hal, PMID:19762432]"}
{"concept_id": "C4236710", "aliases": ["regulation of inhibitory postsynaptic potential"], "types": ["T044"], "canonical_name": "modulation of inhibitory postsynaptic potential", "definition": "Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. [GOC:dos]"}
{"concept_id": "C4236711", "aliases": [], "types": ["T026"], "canonical_name": "endoplasmic reticulum subcompartment", "definition": "A distinct region of the endoplasmic reticulum. [GOC:dos]"}
{"concept_id": "C4236712", "aliases": [], "types": ["T026"], "canonical_name": "endoplasmic reticulum tubular network membrane", "definition": "The membrane of the endoplasmic reticulum tubular network. [PMID:16469703]"}
{"concept_id": "C4236713", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-histidine guanylation", "definition": "The guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine. [RESID:AA0325]"}
{"concept_id": "C4236714", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine sulfation", "definition": "The sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine. [RESID:AA0171]"}
{"concept_id": "C4236715", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine modification to S-amindino-L-cysteine", "definition": "The amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine. [RESID:AA0335]"}
{"concept_id": "C4236716", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine modification to L-cysteine persulfide", "definition": "The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide. [PMID:11592406]"}
{"concept_id": "C4236717", "aliases": [], "types": ["T044"], "canonical_name": "BMP receptor activity", "definition": "Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity. [GOC:BHF, GOC:dos]"}
{"concept_id": "C4236718", "aliases": [], "types": ["T043"], "canonical_name": "depolarization of postsynaptic membrane", "definition": "A process that depolarizes a postsynaptic membrane relative to its resting potential. This has an excitatory effect on the post-synaptic cell, moving the membrane potential towards the firing threshold. [GOC:dos]"}
{"concept_id": "C4236719", "aliases": [], "types": ["T043"], "canonical_name": "hyperpolarization of postsynaptic membrane", "definition": "A process that hyerpolarizes a postsynaptic membrane relative to its resting potential. This has an inhibitory effect on the post-synaptic cell, moving the membrane potential away from the firing threshold. [GOC:dos]"}
{"concept_id": "C4236720", "aliases": [], "types": ["T043"], "canonical_name": "evoked excitatory postsynaptic potential", "definition": "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell induced by the evoked release of many vesicles of excitatory neurotransmitter at the synapse. [GOC:dos]"}
{"concept_id": "C4236721", "aliases": [], "types": ["T043"], "canonical_name": "mini excitatory postsynaptic potential", "definition": "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse. [GOC:dos]"}
{"concept_id": "C4236722", "aliases": [], "types": ["T043"], "canonical_name": "modulation of excitatory postsynaptic potential", "definition": "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dos]"}
{"concept_id": "C4236723", "aliases": ["basal synaptic transmission"], "types": ["T043"], "canonical_name": "spontaneous synaptic transmission", "definition": "The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential. [PMID:20200227]"}
{"concept_id": "C4236724", "aliases": [], "types": ["T045"], "canonical_name": "nuclear chromosome segregation", "definition": "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. [GOC:dos]"}
{"concept_id": "C4236725", "aliases": [], "types": ["T044"], "canonical_name": "nuclear rRNA polyadenylation involved in polyadenylation-dependent rRNA catabolic process", "definition": "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a rRNA, occurring as part of the process of polyadenylation-dependent rRNA catabolism in the nucleus. [GOC:dph, GOC:jl, GOC:tb]"}
{"concept_id": "C4236727", "aliases": ["deadenylation involved in gene silencing by miRNA", "mRNA deadenylation-mediated gene silencing by miRNA"], "types": ["T045"], "canonical_name": "miRNA-mediated gene silencing by mRNA deadenylation", "definition": "An RNA interference pathway in which a miRNA binding to mRNA triggers shortening of the poly(A) tail of a nuclear-transcribed mRNA, resulting in destabilization of the mRNA and a reduction the amount of translated transcript. [GOC:BHF, GOC:dos, PMID:21118121, PMID:23209154]"}
{"concept_id": "C4236729", "aliases": [], "types": ["T026"], "canonical_name": "nonmotile primary cilium membrane"}
{"concept_id": "C4236730", "aliases": [], "types": ["T045"], "canonical_name": "mRNA cleavage involved in gene silencing"}
{"concept_id": "C4236731", "aliases": [], "types": ["T026"], "canonical_name": "postsynapse", "definition": "The part of a synapse that is part of the post-synaptic cell. [GOC:dos]"}
{"concept_id": "C4236732", "aliases": ["presynapse"], "types": ["T026"], "definition": "The part of a synapse that is part of the presynaptic cell. [GOC:dos]", "canonical_name": "presynaptic terminal"}
{"concept_id": "C4236733", "aliases": [], "types": ["T043"], "definition": "The selective autophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents. [GOC:autophagy, GOC:pad, GOC:PARL, PMID:19802565, PMID:20159618, PMID:25497060]", "canonical_name": "xenophagy"}
{"concept_id": "C4236734", "aliases": [], "types": ["T045"], "canonical_name": "ncRNA transcription associated with protein coding gene TSS/TES", "definition": "The transcription of non-coding RNA associated with transcriptional start and end sites of protein coding genes. This occurs at some low level for many protein coding genes. [PMID:20502517]"}
{"concept_id": "C4236735", "aliases": [], "types": ["T045"], "canonical_name": "mRNA cleavage involved in mRNA processing", "definition": "Cleavage of an immature mRNA transcript to produce one or more more mature mRNA transcripts, prior to translation into polypeptide. [GOC:dos]"}
{"concept_id": "C4236736", "aliases": [], "types": ["T026"], "canonical_name": "intracellular vesicle", "definition": "Any vesicle that is part of the intracellular region. [GOC:vesicles]"}
{"concept_id": "C4236737", "aliases": [], "types": ["T043"], "definition": "A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes. [GOC:mtg_apoptosis, PMID:25236395, PMID:26794443]", "canonical_name": "ferroptosis"}
{"concept_id": "C4236738", "aliases": ["blood vessel endothelial cell response to oscillatory fluid shear stress"], "types": ["T043"], "canonical_name": "vascular endothelial cell response to oscillatory fluid shear stress", "definition": "Any response to oscillatory fluid shear stress that occurs in a vascular endothelial cell. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]"}
{"concept_id": "C4236739", "aliases": ["blood vessel endothelial cell response to pulsatile fluid shear stress"], "types": ["T043"], "canonical_name": "vascular endothelial cell response to pulsatile fluid shear stress", "definition": "Any response to pulsatile fluid shear stress that occurs in a vascular endothelial cell. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]"}
{"concept_id": "C4236740", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to oscillatory fluid shear stress", "definition": "Any response to oscillatory fluid shear stress that occurs at the level of a cell. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]"}
{"concept_id": "C4236741", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to pulsatile fluid shear stress", "definition": "Any response to pulsatile fluid shear stress that occurs at the level of a cell. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]"}
{"concept_id": "C4236742", "aliases": [], "types": ["T039"], "canonical_name": "response to oscillatory fluid shear stress", "definition": "Any response to fluid shear stress where the fluid is moving across a solid surface with an oscillatory flow. Disturbed flow patterns at the arterial bifurcations and curvatures may cause endothelial dysfunction, which initiates atherosclerosis. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]"}
{"concept_id": "C4236743", "aliases": [], "types": ["T039"], "canonical_name": "response to pulsatile fluid shear stress", "definition": "Any response to fluid shear stress where the fluid is flowing across a solid surface with periodic variations. For example, the endothelium in straight parts of the artery tree is subjected to pulsatile shear stress with a significant forward direction, which is believed to be an important physiological stimulus enhancing vessel compliance and conferring anti-thrombotic, anti-adhesive, and anti-inflammatory effects. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]"}
{"concept_id": "C4236744", "aliases": ["blood vessel endothelial cell response to laminar fluid shear stress"], "types": ["T043"], "canonical_name": "vascular endothelial cell response to laminar fluid shear stress", "definition": "Any response to laminar fluid shear stress in a vascular endothelial cell. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]"}
{"concept_id": "C4236745", "aliases": ["blood vessel endothelial cell response to fluid shear stress"], "types": ["T043"], "canonical_name": "vascular endothelial cell response to fluid shear stress", "definition": "Any response to fluid shear stress in a vascular endothelial cell. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]"}
{"concept_id": "C4236746", "aliases": [], "types": ["T045"], "canonical_name": "telomere maintenance via base-excision repair", "definition": "A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature. [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:24703901]"}
{"concept_id": "C4236747", "aliases": [], "types": ["T044"], "canonical_name": "tRNA 5-carboxymethoxyuridine methyltransferase activity", "definition": "Catalysis of the transfer of a methyl group from S-adenosylmethionine to a 5-carboxymethoxy-modified uridine residue in a tRNA molecule. [GOC:imk, PMID:26681692]"}
{"concept_id": "C4236748", "aliases": ["kinase-STAT cascade", "STAT signalling pathway", "kinase activated-STAT cascade"], "types": ["T044"], "canonical_name": "receptor signaling pathway via STAT", "definition": "An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. [GOC:rjd, PMID:21534947, PMID:24587195]"}
{"concept_id": "C4236749", "aliases": ["establishment of macromolecular complex localization to telomere", "establishment of macromolecular complex localisation to telomere"], "types": ["T043"], "canonical_name": "establishment of protein-containing complex localization to telomere", "definition": "The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome. [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433]"}
{"concept_id": "C4236750", "aliases": ["establishment of RNA localisation to telomere"], "types": ["T045"], "canonical_name": "establishment of RNA localization to telomere", "definition": "The directed movement of RNA to a specific location in the telomeric region of a chromosome. [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433]"}
{"concept_id": "C4236751", "aliases": [], "types": ["T026"], "canonical_name": "ocelloid", "definition": "Eye-like subcellular structure found in dinoflagellates (a large group of single-celled eukaryotes). Consists of subcellular analogues to a cornea, lens, iris, and retina. Ocelloids are built from pre-existing organelles, including a cornea-like layer made of mitochondria and a retinal body made of anastomosing plastids. [GOC:ar, PMID:26131935]"}
{"concept_id": "C4236752", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-K4 monomethylation", "definition": "The modification of histone H3 by addition of one methyl group to lysine at position 4 of the histone. [GOC:jh2, PMID:26320581]"}
{"concept_id": "C4236753", "aliases": [], "types": ["T026"], "canonical_name": "bacterial extracellular vesicle", "definition": "Small membrane vesicle (< 1 um) that buds off a prokaryotic cell plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, and more. Important in intercellular communication and pathogenesis; can exist within host cells. [GOC:aa, PMID:25704309]"}
{"concept_id": "C4236754", "aliases": ["ER-associated glycoprotein degradation", "glycoprotein ERAD", "gpERAD"], "types": ["T043"], "canonical_name": "ubiquitin-dependent glycoprotein ERAD pathway", "definition": "An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component. [GOC:al, GOC:bf, PMID:16079177]"}
{"concept_id": "C4236755", "aliases": ["telomeric repeat-containing RNA transcription from RNA pol II promoter"], "types": ["T045"], "canonical_name": "telomeric repeat-containing RNA transcription by RNA polymerase II", "definition": "The synthesis of telomeric repeat-containing RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II promoter. [GOC:al, PMID:22139915]"}
{"concept_id": "C4236756", "aliases": ["cilium plasm"], "types": ["T026"], "canonical_name": "ciliary plasm", "definition": "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]"}
{"concept_id": "C4236757", "aliases": ["acetylcholine receptor signalling pathway"], "types": ["T043"], "canonical_name": "acetylcholine receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. [GOC:mah]"}
{"concept_id": "C4236758", "aliases": [], "types": ["T044"], "canonical_name": "calcium ion transmembrane transport via low voltage-gated calcium channel", "definition": "A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel. [GOC:bf, GOC:PARL, PMID:20371816]"}
{"concept_id": "C4236759", "aliases": [], "types": ["T043"], "canonical_name": "intermicrovillar adhesion", "definition": "The cell-cell adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin. [GOC:lb, PMID:24725409]"}
{"concept_id": "C4236760", "aliases": [], "types": ["T026"], "canonical_name": "endothelial cell-matrix adhesion via fibronectin", "definition": "The binding of an endothelial cell to the extracellular matrix via fibronectin. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962]"}
{"concept_id": "C4236761", "aliases": [], "types": ["T026"], "canonical_name": "endothelial cell-matrix adhesion", "definition": "The binding of an endothelial cell to the extracellular matrix via adhesion molecules. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962]"}
{"concept_id": "C4236762", "aliases": [], "types": ["T043"], "canonical_name": "telomerase RNA localization", "definition": "Any process in which telomerase RNA is transported to, or maintained in, a specific location. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]"}
{"concept_id": "C4236763", "aliases": [], "types": ["T043"], "canonical_name": "telomerase RNA localization to Cajal body", "definition": "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]"}
{"concept_id": "C4236764", "aliases": [], "types": ["T043"], "canonical_name": "RNA localization to Cajal body", "definition": "A process in which an RNA is transported to, or maintained in, a Cajal body. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]"}
{"concept_id": "C4236765", "aliases": ["TERC stabilization"], "types": ["T045"], "canonical_name": "telomerase RNA stabilization", "definition": "Prevention of degradation of telomerase RNA (TERC) molecules. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]"}
{"concept_id": "C4236766", "aliases": [], "types": ["T043"], "canonical_name": "cell chemotaxis to vascular endothelial growth factor", "definition": "The directed movement of a motile cell in response to the presence of vascular endothelial growth factor (VEGF). [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851]"}
{"concept_id": "C4236767", "aliases": [], "types": ["T043"], "canonical_name": "scaRNA localization to Cajal body", "definition": "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]"}
{"concept_id": "C4236768", "aliases": ["response to crowding"], "types": ["T039"], "canonical_name": "response to high population density", "definition": "Any process that results in a change in state or activity of a cell or a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a higher than normal number of multicellular organisms living per unit area. [GOC:mr, PMID:26439857]"}
{"concept_id": "C4236769", "aliases": ["galanin-activated signalling pathway"], "types": ["T044"], "canonical_name": "galanin-activated signaling pathway", "definition": "The series of molecular signals generated as a consequence of the peptide neurotransmitter galanin binding to a cell surface receptor. [GOC:lb, PMID:25691535]"}
{"concept_id": "C4236770", "aliases": [], "types": ["T044"], "canonical_name": "ATP hydrolysis coupled transmembrane transport"}
{"concept_id": "C4236771", "aliases": [], "types": ["T040"], "canonical_name": "walking behavior", "definition": "The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. [GOC:tb]"}
{"concept_id": "C4236772", "aliases": [], "types": ["T026"], "canonical_name": "cone matrix sheath", "definition": "A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments. [GOC:mr, PMID:2055688]"}
{"concept_id": "C4236773", "aliases": ["t-loop disassembly", "T loop disassembly"], "types": ["T045"], "canonical_name": "telomeric loop disassembly", "definition": "The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:22579284]"}
{"concept_id": "C4236774", "aliases": ["telomeric circle formation"], "types": ["T045"], "canonical_name": "t-circle formation", "definition": "A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD). [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19214183, PMID:19581589, PMID:19809492, PMID:19858100]"}
{"concept_id": "C4236775", "aliases": [], "types": ["T045"], "canonical_name": "double-stranded/single-stranded junction telomeric DNA binding", "definition": "Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang. [GOC:BHF, GOC:BHF_telomere, GOC:bhm, GOC:nc, PMID:21852327]"}
{"concept_id": "C4236776", "aliases": [], "types": ["T026"], "canonical_name": "basolateral recycling endosome", "definition": "Tubulo-vesicular structure located in the basolateral cytoplasm that participates in basolateral cargo recycling in polarized epithelial cells. [PMID:11389442, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315]"}
{"concept_id": "C4236777", "aliases": [], "types": ["T026"], "canonical_name": "apical recycling endosome", "definition": "Tubulo-vesicular structure located in the apical cytoplasm that participates in apical cargo recycling in polarized epithelial cells. [PMID:12669082, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315]"}
{"concept_id": "C4236778", "aliases": [], "types": ["T026"], "canonical_name": "basolateral cytoplasm", "definition": "The region of the cytoplasm located at the basolateral side of the cell. Used in reference to animal polarized epithelial cells. [PMID:17494872]"}
{"concept_id": "C4236779", "aliases": [], "types": ["T026"], "canonical_name": "apical cytoplasm", "definition": "The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells. [PMID:17494872]"}
{"concept_id": "C4236780", "aliases": ["cellular response to OGD"], "types": ["T043"], "canonical_name": "cellular response to oxygen-glucose deprivation", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose. [GOC:sl, PMID:21525936]"}
{"concept_id": "C4236781", "aliases": ["response to OGD"], "types": ["T039"], "canonical_name": "response to oxygen-glucose deprivation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose. [GOC:sl, PMID:21525936]"}
{"concept_id": "C4236782", "aliases": [], "types": ["T038"], "canonical_name": "response to environmental enrichment", "definition": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment. [GOC:sl, PMID:23644055, PMID:25934034]"}
{"concept_id": "C4236784", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tRNA processing", "definition": "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion. [GOC:vw]"}
{"concept_id": "C4236785", "aliases": [], "types": ["T044"], "canonical_name": "APC-Cdc20 complex inhibitor activity"}
{"concept_id": "C4236786", "aliases": [], "types": ["T042"], "canonical_name": "inflorescence phyllotactic patterning", "definition": "The radial pattern formation process that results in the formation of flowers around a central axis in an inflorescence meristem. [PMID:25352850]"}
{"concept_id": "C4236787", "aliases": [], "types": ["T026"], "canonical_name": "microsporidian-type exospore", "definition": "The dense, protein rich outermost layer of a microsporidian spore wall that lies above the endospore. [PMID:19457051, PMID:25363531]"}
{"concept_id": "C4236788", "aliases": [], "types": ["T026"], "canonical_name": "microsporidian-type endospore", "definition": "The middle layer in a microsporidian spore wall that lies under the exospore and outside the plasma membrane, containing chitin and proteins. [PMID:19457051]"}
{"concept_id": "C4236789", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine", "definition": "The phosphatidylcholine biosynthetic process that involves the two-step acylation of sn-glycero-3-phosphocholine to a phosphatidylcholine. [MetaCyc:PWY-7470, PMID:24329598, PMID:27758859]"}
{"concept_id": "C4236790", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol", "definition": "The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine. [MetaCyc:PWY-6826]"}
{"concept_id": "C4236791", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine biosynthesis from phosphatidylethanolamine", "definition": "The phosphatidylcholine biosynthetic process that depends on direct conversion of the phosphatidyl-base phosphatidylethanolamine to phosphatidylcholine by successive methylations. [MetaCyc:PWY-6825]"}
{"concept_id": "C4236792", "aliases": [], "types": ["T026"], "canonical_name": "inner dense plaque of desmosome", "definition": "The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane. [PMID:20066089]"}
{"concept_id": "C4236793", "aliases": [], "types": ["T026"], "canonical_name": "outer dense plaque of desmosome", "definition": "The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane. [PMID:20066089]"}
{"concept_id": "C4236794", "aliases": ["desmoglea"], "types": ["T026"], "canonical_name": "extracellular core region of desmosome", "definition": "The desmosomal part containing the desmosomal cadherins, desmogleins and desmocollins, that establish contact and adhere to neighboring cells in a Ca2+-dependent manner. [PMID:20066089]"}
{"concept_id": "C4236795", "aliases": [], "types": ["T043"], "canonical_name": "microglial cell mediated cytotoxicity", "definition": "The directed killing of a target cell by a microglial cell. [GOC:BHF, GOC:nc, PMID:19100238]"}
{"concept_id": "C4236796", "aliases": ["G-protein coupled acetylcholine receptor signalling pathway involved in heart process", "G-protein coupled acetylcholine receptor signaling pathway involved in heart process"], "types": ["T043"], "canonical_name": "G protein-coupled acetylcholine receptor signaling pathway involved in heart process", "definition": "A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]"}
{"concept_id": "C4236798", "aliases": ["negative regulation of pulmonary blood pressure"], "types": ["T038"], "canonical_name": "negative regulation of lung blood pressure", "definition": "The process that decreases the force with which blood travels through the lungs. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:dph, PMID:22161164]"}
{"concept_id": "C4236799", "aliases": ["positive regulation of pulmonary blood pressure"], "types": ["T040"], "canonical_name": "positive regulation of lung blood pressure", "definition": "The process that increases the force with which blood travels through the lungs. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22161164]"}
{"concept_id": "C4236800", "aliases": ["modulation by virus of host NIK/NF-kappaB signaling"], "types": ["T043"], "canonical_name": "modulation by virus of host NIK/NF-kappaB cascade", "definition": "Any process in which a virus effect a change in the frequency, rate or extent of NIK/NF-kappaB signaling in the host. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:26764146]"}
{"concept_id": "C4236801", "aliases": [], "types": ["T043"], "canonical_name": "late endosome to lysosome transport via multivesicular body sorting pathway", "definition": "The directed movement of substances from late endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome. [GOC:dph]"}
{"concept_id": "C4236802", "aliases": ["fusion of multivesicular body to lysosome", "fusion of MVB to lysosome", "MVB-lysosome fusion"], "types": ["T043"], "canonical_name": "multivesicular body-lysosome fusion", "definition": "The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle. [GOC:dph, GOC:pad, GOC:PARL, PMID:21118109]"}
{"concept_id": "C4236803", "aliases": [], "types": ["T043"], "canonical_name": "CAMKK-AMPK signaling cascade", "definition": "The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity. [GOC:dph, GOC:pad, GOC:PARL, PMID:23010169, PMID:24709372]"}
{"concept_id": "C4236804", "aliases": ["latrophilin binding", "lasso receptor binding"], "types": ["T044"], "canonical_name": "alpha-latrotoxin receptor binding", "definition": "Binding to an alpha-latrotoxin receptor. [GOC:dph, PMID:21724987]"}
{"concept_id": "C4236805", "aliases": [], "types": ["T039"], "canonical_name": "antifungal innate immune response", "definition": "An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [GOC:dph, PMID:22470487]"}
{"concept_id": "C4236806", "aliases": ["2-hydroxyglutarate dehydrogenase activity, reverse reaction"], "types": ["T044"], "canonical_name": "alpha-ketoglutarate reductase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + reduced acceptor = (S)-2-hydroxyglutarate + acceptor. [EC:1.1.99.2, GOC:dph, PMID:26774271, RHEA:21254]"}
{"concept_id": "C4236807", "aliases": ["alpha-ketoglutarate reductase activity, reverse reaction"], "types": ["T044"], "canonical_name": "2-hydroxyglutarate dehydrogenase activity, forward reaction", "definition": "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor. [EC:1.1.99.2, GOC:dph, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]"}
{"concept_id": "C4236808", "aliases": [], "types": ["T043"], "canonical_name": "leukocyte adhesion to arterial endothelial cell", "definition": "The attachment of a leukocyte to an arterial endothelial cell via adhesion molecules. [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22267480]"}
{"concept_id": "C4236809", "aliases": [], "types": ["T043"], "canonical_name": "leukocyte adhesion to vascular endothelial cell", "definition": "The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:23897866]"}
{"concept_id": "C4236810", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of circulating fibrinogen levels", "definition": "Any process that increases the quantity of fibrinogen circulating in the bloodstream. [GOC:bf, GOC:BHF, GOC:BHF_miRNA, PMID:20570858]"}
{"concept_id": "C4236811", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of circulating fibrinogen levels", "definition": "Any process that reduces the quantity of fibrinogen circulating in the bloodstream. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:20570858]"}
{"concept_id": "C4236812", "aliases": ["substrate sequestration to phagophore", "substrate sequestration to autophagosome"], "types": ["T043"], "canonical_name": "substrate localization to autophagosome", "definition": "The localization process by which an autophagic substrate is delivered to a forming autophagosome. [GOC:dph, GOC:pad, GOC:PARL, PMID:23545414]"}
{"concept_id": "C4236813", "aliases": ["TERRA binding"], "types": ["T045"], "canonical_name": "telomeric repeat-containing RNA binding", "definition": "Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats. [GOC:BHF, GOC:BHF_telomere, GOC:dph, GOC:jbu, PMID:20655916]"}
{"concept_id": "C4236814", "aliases": [], "types": ["T045"], "canonical_name": "forked DNA-dependent helicase activity", "definition": "Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis. [GOC:dph, PMID:26277776]"}
{"concept_id": "C4236815", "aliases": [], "types": ["T044"], "canonical_name": "single-stranded DNA-dependent CTPase activity"}
{"concept_id": "C4236818", "aliases": [], "types": ["T044"], "canonical_name": "GTPase activity, coupled"}
{"concept_id": "C4236819", "aliases": [], "types": ["T038"], "canonical_name": "motor learning", "definition": "Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience. [GOC:bf, GOC:PARL, Wikipedia:Motor_learning]"}
{"concept_id": "C4236821", "aliases": [], "types": ["T044"], "canonical_name": "protein targeting to lysosome involved in chaperone-mediated autophagy", "definition": "The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor. [GOC:dph, GOC:pad, GOC:PARL, PMID:22748206]"}
{"concept_id": "C4236822", "aliases": [], "types": ["T044"], "canonical_name": "protein lipidation involved in autophagosome assembly", "definition": "The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly. [GOC:autophagy, GOC:dph, PMID:11096062, PMID:11100732, PMID:15277523]"}
{"concept_id": "C4236823", "aliases": [], "types": ["T043"], "canonical_name": "late endosomal microautophagy", "definition": "The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment. [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:21238931]"}
{"concept_id": "C4236824", "aliases": [], "types": ["T043"], "canonical_name": "leukotriene signaling pathway", "definition": "A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:dph, PMID:21771892]"}
{"concept_id": "C4236825", "aliases": [], "types": ["T043"], "canonical_name": "engulfment of target by autophagosome", "definition": "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy. [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL]"}
{"concept_id": "C4236826", "aliases": ["dynamin-like protein-mediated stimulation of mitophagy in response to mitochondrial depolarization"], "types": ["T043"], "canonical_name": "DNM1L-mediated stimulation of mitophagy in response to mitochondrial depolarization", "definition": "A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a DNM1L-family molecule. [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:25349190]"}
{"concept_id": "C4236827", "aliases": ["PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization", "Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization"], "types": ["T043"], "canonical_name": "parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization", "definition": "A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule. [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:25349190]"}
{"concept_id": "C4236828", "aliases": [], "types": ["T044"], "canonical_name": "peptide-lysine-N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide. [GOC:dph]"}
{"concept_id": "C4236829", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial acetyl-CoA biosynthetic process from pyruvate", "definition": "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA. [GOC:dph, ISBN:0201090910]"}
{"concept_id": "C4236830", "aliases": [], "types": ["T045"], "canonical_name": "C-rich strand telomeric DNA binding", "definition": "Binding to C-rich, single-stranded, telomere-associated DNA. [GOC:dph, GOC:kmv, PMID:18329362]"}
{"concept_id": "C4236831", "aliases": [], "types": ["T044"], "canonical_name": "GDP-mannose biosynthetic process from fructose-6-phosphate", "definition": "The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate. [GOC:dph, PMID:16339137]"}
{"concept_id": "C4236832", "aliases": [], "types": ["T044"], "canonical_name": "GDP-mannose biosynthetic process from mannose", "definition": "The chemical reactions and pathways resulting in the formation of GDP-mannose from mannose. [GOC:dph, PMID:16339137, PMID:24218558]"}
{"concept_id": "C4236833", "aliases": [], "types": ["T044"], "canonical_name": "methylglyoxal catabolic process to lactate", "definition": "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate. [GOC:dph, PMID:2198020]"}
{"concept_id": "C4236834", "aliases": ["mitochondrion degradation"], "types": ["T043"], "canonical_name": "mitochondrion disassembly", "definition": "The disaggregation of a mitochondrion into its constituent components. [GOC:autophagy, PMID:25009776]"}
{"concept_id": "C4236835", "aliases": [], "types": ["T043"], "canonical_name": "cytosolic lipolysis", "definition": "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases. [GOC:autophagy]"}
{"concept_id": "C4236836", "aliases": [], "types": ["T043"], "definition": "The selective autophagy process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions. [GOC:autophagy, PMID:23708524, PMID:26076903]", "canonical_name": "lipophagy"}
{"concept_id": "C4236837", "aliases": [], "types": ["T043"], "canonical_name": "glycophagy", "definition": "The selective autophagy process in which cellular glycogen is delivered to the vacuole and degraded in response to changing cellular conditions. [GOC:autophagy, PMID:21893048]"}
{"concept_id": "C4236838", "aliases": ["sulfoglycolysis"], "types": ["T044"], "canonical_name": "sulphoglycolysis", "definition": "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and pyruvate. [GOC:dph, PMID:24463506]"}
{"concept_id": "C4236839", "aliases": [], "types": ["T038"], "canonical_name": "6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-)", "definition": "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfopropanediol(1-). [GOC:dph, PMID:14602517, PMID:24463506]"}
{"concept_id": "C4236840", "aliases": [], "types": ["T044"], "canonical_name": "6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde", "definition": "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). [GOC:dph, PMID:24463506]"}
{"concept_id": "C4236841", "aliases": [], "types": ["T044"], "canonical_name": "glucose catabolic process to pyruvate utilizing ADP", "definition": "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, with the concomitant production of a small amount of ATP and the utilization of ADP in the initial kinase reactions. [GOC:dph, MetaCyc:P341-PWY]"}
{"concept_id": "C4236842", "aliases": ["glucose catabolism to pyruvate"], "types": ["T044"], "canonical_name": "glucose catabolic process to pyruvate", "definition": "The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate. [GOC:dph]"}
{"concept_id": "C4236844", "aliases": [], "types": ["T043"], "canonical_name": "miRNA export from nucleus", "definition": "The directed movement of a processed miRNA from the nucleus to the cytoplasm. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15738428, PMID:21554756]"}
{"concept_id": "C4236846", "aliases": ["folate receptor activity"], "types": ["T044"], "canonical_name": "folic acid receptor activity", "definition": "Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis. [GOC:BHF, GOC:hal]"}
{"concept_id": "C4236847", "aliases": [], "types": ["T042"], "canonical_name": "anterior neural tube closure", "definition": "The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline. [GOC:BHF, GOC:dph, GOC:hal, PMID:17286298]"}
{"concept_id": "C4236848", "aliases": [], "types": ["T044"], "canonical_name": "tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase", "definition": "Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine. [EC:2.8.4.5]"}
{"concept_id": "C4236849", "aliases": [], "types": ["T044"], "canonical_name": "N(6)-L-threonylcarbamoyladenine synthase activity", "definition": "Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA. [EC:2.3.1.234]"}
{"concept_id": "C4236850", "aliases": [], "types": ["T044"], "canonical_name": "L-threonylcarbamoyladenylate synthase", "definition": "Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O. [EC:2.7.7.87]"}
{"concept_id": "C4236851", "aliases": ["ER autophagy", "reticulophagy", "endoplasmic reticulum autophagy", "autophagy of the endoplasmic reticulum", "autophagy of the ER"], "types": ["T043"], "definition": "The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]", "canonical_name": "ER-phagy"}
{"concept_id": "C4236852", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-5-taurinomethyluridine 2-sulfurtransferase", "definition": "Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+. [GOC:dph, PMID:15509579]"}
{"concept_id": "C4236853", "aliases": [], "types": ["T043"], "canonical_name": "extracellular exosome macropinocytosis", "definition": "The single-organism macropinocytosis process that results in the uptake of an extracellular exosome. [GOC:dph, PMID:24951588]"}
{"concept_id": "C4236854", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic process from sucrose through glucose and fructose", "definition": "The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. [GOC:dph, GOC:glycolysis, MetaCyc:PWY-1042, PMID:15012287]"}
{"concept_id": "C4236855", "aliases": [], "types": ["T044"], "canonical_name": "sucrose catabolic process to fructose-6-phosphate through glucose and fructose", "definition": "The chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates. [GOC:dph, GOC:glycolysis, MetaCyc:PWY-621, PMID:15012287]"}
{"concept_id": "C4236856", "aliases": [], "types": ["T044"], "canonical_name": "glycolytic process from sucrose", "definition": "The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. [GOC:dph, GOC:glycolysis, PMID:15012287]"}
{"concept_id": "C4236857", "aliases": [], "types": ["T026"], "canonical_name": "bacterial outer membrane vesicle", "definition": "A spherical, bilayered proteolipid vesicle released from gram-negative bacterial outer membranes. [GOC:dph, GOC:pr, PMID:20596524]"}
{"concept_id": "C4236858", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine deglutarylation", "definition": "The removal of a glutaryl group (CO-CH2-CH2--CH2-CO) from a glutarylated lysine residue in a peptide or protein. [GOC:dph, PMID:24703693]"}
{"concept_id": "C4236859", "aliases": [], "types": ["T044"], "canonical_name": "protein deglutarylation", "definition": "The removal of a glutaryl group (CO-CH2-CH2-CH2-CO) from a residue in a peptide or protein. [GOC:dph, PMID:24703693]"}
{"concept_id": "C4236860", "aliases": [], "types": ["T044"], "canonical_name": "protein-glutaryllysine deglutarylase activity", "definition": "Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. [GOC:dph, PMID:24703693]"}
{"concept_id": "C4236861", "aliases": [], "types": ["T044"], "canonical_name": "alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity", "definition": "Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine. [EC:2.7.8.37, GOC:dph, PMID:22089136]"}
{"concept_id": "C4236862", "aliases": [], "types": ["T044"], "canonical_name": "cellular detoxification of hydrogen peroxide", "definition": "Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration. [GOC:dph, GOC:vw]"}
{"concept_id": "C4236863", "aliases": ["lipoyl-X-hydrolase"], "types": ["T044"], "canonical_name": "lipoamidase activity", "definition": "Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein. [GOC:dph, PMID:14086741]"}
{"concept_id": "C4236864", "aliases": [], "types": ["T030"], "canonical_name": "tricellular tight junction", "definition": "An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet. [GOC:dk, GOC:dph, PMID:22520461, PMID:25822906]"}
{"concept_id": "C4236865", "aliases": [], "types": ["T044"], "canonical_name": "calcium ion transmembrane transport via high voltage-gated calcium channel", "definition": "A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel. [GOC:dph]"}
{"concept_id": "C4236866", "aliases": [], "types": ["T044"], "canonical_name": "ADP-activated adenosine receptor activity"}
{"concept_id": "C4236867", "aliases": [], "types": ["T044"], "canonical_name": "ATP-activated adenosine receptor activity"}
{"concept_id": "C4236868", "aliases": ["mitotic cytokinesis checkpoint", "signal transduction involved in mitotic cytokinesis checkpoint", "signalling pathway involved in mitotic cytokinesis checkpoint", "signaling pathway involved in mitotic cytokinesis checkpoint", "signalling cascade involved in mitotic cytokinesis checkpoint"], "types": ["T043"], "canonical_name": "mitotic cytokinesis checkpoint signaling", "definition": "A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed. [GOC:jl, GOC:mtg_cell_cycle, PMID:17538026]"}
{"concept_id": "C4236869", "aliases": ["astrocyte-dopaminergic neuron cell signaling"], "types": ["T043"], "canonical_name": "astrocyte-dopaminergic neuron signaling", "definition": "Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron. [GOC:bf, GOC:PARL, PMID:12794311, PMID:21752258]"}
{"concept_id": "C4236870", "aliases": ["chemorepulsion of 5-HT axon"], "types": ["T043"], "canonical_name": "chemorepulsion of serotonergic neuron axon", "definition": "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]"}
{"concept_id": "C4236871", "aliases": ["chemoattraction of 5-HT axon", "chemoattraction of serotonergic axon"], "types": ["T043"], "canonical_name": "chemoattraction of serotonergic neuron axon", "definition": "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal. [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]"}
{"concept_id": "C4236872", "aliases": ["chemoattraction of DA axon", "chemoattraction of dopaminergic axon"], "types": ["T043"], "canonical_name": "chemoattraction of dopaminergic neuron axon", "definition": "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal. [GOC:bf, GOC:PARL, PMID:21106844]"}
{"concept_id": "C4236873", "aliases": ["serotonergic axon guidance", "5-HT axon guidance"], "types": ["T043"], "canonical_name": "serotonergic neuron axon guidance", "definition": "The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues. [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]"}
{"concept_id": "C4236874", "aliases": ["DA axon guidance", "mdDA axon guidance", "dopaminergic axon guidance"], "types": ["T043"], "canonical_name": "dopaminergic neuron axon guidance", "definition": "The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues. [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308]"}
{"concept_id": "C4236875", "aliases": [], "types": ["T044"], "canonical_name": "trimming of second mannose on A branch", "definition": "The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. [GOC:bf, GOC:PARL, PMID:12829701]"}
{"concept_id": "C4236876", "aliases": [], "types": ["T044"], "canonical_name": "trimming of first mannose on A branch", "definition": "The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. [GOC:bf, GOC:PARL, PMID:12829701]"}
{"concept_id": "C4236877", "aliases": ["glycoprotein mannose trimming on C branch"], "types": ["T044"], "canonical_name": "trimming of terminal mannose on C branch", "definition": "The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. [GOC:bf, GOC:PARL, PMID:20065073]"}
{"concept_id": "C4236878", "aliases": ["glycoprotein mannose trimming on B branch"], "types": ["T044"], "canonical_name": "trimming of terminal mannose on B branch", "definition": "The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. [GOC:bf, GOC:PARL, KEGG_REACTION:R06722, PMID:22160784]"}
{"concept_id": "C4236879", "aliases": [], "types": ["T044"], "canonical_name": "protein alpha-1,2-demannosylation", "definition": "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. [GOC:bf, GOC:PARL, PMID:21062743, PMID:25092655]"}
{"concept_id": "C4236880", "aliases": ["protein de-mannosylation"], "types": ["T044"], "canonical_name": "protein demannosylation", "definition": "The removal of one or more mannose residues from a mannosylated protein. [GOC:bf, GOC:PARL, PMID:25092655]"}
{"concept_id": "C4236881", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of unfolded protein", "definition": "Maintaining a protein in an unfolded, soluble state. [GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, PMID:21636303]"}
{"concept_id": "C4236882", "aliases": ["prosaposin-activated receptor activity"], "types": ["T044"], "canonical_name": "prosaposin receptor activity", "definition": "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D). [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493]"}
{"concept_id": "C4236883", "aliases": ["membrane fusion involved in Golgi reassembly", "post-mitotic fusion of Golgi membranes"], "types": ["T043"], "canonical_name": "Golgi membrane fusion", "definition": "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. [GOC:bf, GOC:PARL, PMID:12473691]"}
{"concept_id": "C4236884", "aliases": [], "types": ["T040"], "canonical_name": "myxococcal fruiting body development", "definition": "The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure. [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786]"}
{"concept_id": "C4236885", "aliases": [], "types": ["T044"], "canonical_name": "glial cell-derived neurotrophic factor receptor binding", "definition": "A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors. [GOC:vw, PMID:11476867]"}
{"concept_id": "C4236887", "aliases": [], "types": ["T043"], "canonical_name": "stem cell population maintenance", "definition": "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types. [GOC:mah, ISBN:0878932437]"}
{"concept_id": "C4236888", "aliases": [], "types": ["T043"], "canonical_name": "axo-dendritic transport", "definition": "The directed movement of organelles or molecules along microtubules in neuron projections. [ISBN:0815316194]"}
{"concept_id": "C4236889", "aliases": [], "types": ["T045"], "canonical_name": "mRNA 3'-end processing by stem-loop binding and cleavage", "definition": "Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine. [GOC:mah, GOC:tb, PMID:17998288]"}
{"concept_id": "C4236891", "aliases": ["downregulation of photosynthesis", "down-regulation of photosynthesis"], "types": ["T043"], "canonical_name": "down regulation of photosynthesis"}
{"concept_id": "C4236892", "aliases": ["upregulation of voltage gated sodium channel activity", "up regulation of voltage-sensitive sodium channel", "up-regulation of voltage-dependent sodium channel activity", "up-regulation of voltage-sensitive sodium channel", "upregulation of voltage-dependent sodium channel activity", "upregulation of voltage-sensitive sodium channel", "up-regulation of voltage-gated sodium ion channel activity", "up-regulation of voltage gated sodium channel activity", "upregulation of voltage-gated sodium ion channel activity", "upregulation of voltage-gated sodium channel activity", "up regulation of voltage-dependent sodium channel activity", "up regulation of voltage-gated sodium ion channel activity", "up-regulation of voltage-gated sodium channel activity", "up regulation of voltage-gated sodium channel activity"], "types": ["T044"], "canonical_name": "up regulation of voltage gated sodium channel activity"}
{"concept_id": "C4236893", "aliases": ["down-regulation of voltage-gated sodium channel activity", "down regulation of voltage-gated sodium channel activity", "down regulation of voltage-sensitive sodium channel", "downregulation of voltage gated sodium channel activity", "down-regulation of voltage-gated sodium ion channel activity", "down regulation of voltage-dependent sodium channel activity", "downregulation of voltage-gated sodium ion channel activity", "downregulation of voltage-gated sodium channel activity", "down-regulation of voltage-dependent sodium channel activity", "downregulation of voltage-sensitive sodium channel", "downregulation of voltage-dependent sodium channel activity", "down regulation of voltage-gated sodium ion channel activity", "down-regulation of voltage gated sodium channel activity", "down-regulation of voltage-sensitive sodium channel"], "types": ["T044"], "canonical_name": "down regulation of voltage gated sodium channel activity"}
{"concept_id": "C4236894", "aliases": ["upregulation of canonical Wnt receptor signaling pathway involved in heart development", "up-regulation of canonical Wnt receptor signaling pathway involved in heart development", "up-regulation of canonical Wnt signaling pathway involved in heart development", "up regulation of canonical Wnt receptor signalling pathway involved in heart development", "upregulation of canonical Wnt receptor signalling pathway involved in heart development", "up-regulation of canonical Wnt-activated signaling pathway involved in heart development", "up regulation of canonical Wnt-activated signaling pathway involved in heart development", "upregulation of canonical Wnt-activated signaling pathway involved in heart development", "upregulation of canonical Wnt signaling pathway involved in heart development", "up regulation of canonical Wnt signaling pathway involved in heart development", "up-regulation of canonical Wnt receptor signalling pathway involved in heart development"], "types": ["T043"], "canonical_name": "up regulation of canonical Wnt receptor signaling pathway involved in heart development"}
{"concept_id": "C4236895", "aliases": ["up regulation of L-lysine import into cell", "upregulation of L-lysine import into cell", "up-regulation of L-lysine import into cell", "positive regulation of L-lysine import into cell"], "types": ["T043"], "canonical_name": "positive regulation of L-lysine import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of L-lysine import into cell. [GO_REF:0000058, GOC:TermGenie, PMID:7499219]"}
{"concept_id": "C4236896", "aliases": ["down regulation of establishment of macromolecular complex localisation to telomere", "down-regulation of establishment of macromolecular complex localization to telomere", "down regulation of establishment of macromolecular complex localization to telomere", "negative regulation of establishment of macromolecular complex localisation to telomere", "negative regulation of establishment of macromolecular complex localization to telomere", "down-regulation of establishment of macromolecular complex localisation to telomere", "downregulation of establishment of macromolecular complex localisation to telomere", "downregulation of establishment of macromolecular complex localization to telomere"], "types": ["T043"], "canonical_name": "negative regulation of establishment of protein-containing complex localization to telomere", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]"}
{"concept_id": "C4236897", "aliases": ["up-regulation of protein localization in cell-cell adherens junction", "up regulation of protein localization in cell-cell adherens junction", "up regulation of protein localisation in cell-cell adherens junction", "upregulation of protein localization in cell-cell adherens junction", "up regulation of protein localization to cell-cell adherens junction", "up-regulation of protein localization to cell-cell adherens junction", "upregulation of protein localisation to cell-cell adherens junction", "upregulation of protein localisation in cell-cell adherens junction", "up-regulation of protein localisation in cell-cell adherens junction", "upregulation of protein localization to cell-cell adherens junction", "up-regulation of protein localisation to cell-cell adherens junction", "up regulation of protein localisation to cell-cell adherens junction"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to adherens junction", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237]"}
{"concept_id": "C4236898", "aliases": ["upregulation of neuromuscular junction development", "upregulation of neuromuscular junction organization", "up regulation of neuromuscular junction organization", "up-regulation of neuromuscular junction organization", "up-regulation of neuromuscular junction development"], "types": ["T044"], "canonical_name": "up regulation of neuromuscular junction development"}
{"concept_id": "C4236899", "aliases": ["downregulation of neuromuscular junction development", "down-regulation of neuromuscular junction organization", "downregulation of neuromuscular junction organization", "down regulation of neuromuscular junction organization", "down-regulation of neuromuscular junction development"], "types": ["T043"], "canonical_name": "down regulation of neuromuscular junction development"}
{"concept_id": "C4236900", "aliases": ["upregulation of convergent extension involved in rhombomere morphogenesis", "up-regulation of convergent extension involved in rhombomere morphogenesis"], "types": ["T044"], "canonical_name": "up regulation of convergent extension involved in rhombomere morphogenesis"}
{"concept_id": "C4236901", "aliases": ["down-regulation of convergent extension involved in somitogenesis", "downregulation of convergent extension involved in somitogenesis"], "types": ["T044"], "canonical_name": "down regulation of convergent extension involved in somitogenesis"}
{"concept_id": "C4236902", "aliases": ["upregulation of fatty acid beta-oxidation by octopamine signaling pathway", "up-regulation of fatty acid beta-oxidation by octopamine signaling pathway"], "types": ["T044"], "canonical_name": "up regulation of fatty acid beta-oxidation by octopamine signaling pathway"}
{"concept_id": "C4282088", "aliases": ["dynactin complex"], "types": ["T026"], "definition": "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach. [ISBN:0198506732]", "canonical_name": "dynactin complex location"}
{"concept_id": "C4316807", "aliases": [], "types": ["T026"], "definition": "Any microtubule in the cytoplasm of a cell. [GOC:mah]", "canonical_name": "cytoplasmic microtubule"}
{"concept_id": "C4316901", "aliases": ["plasma membrane invagination"], "types": ["T043"], "canonical_name": "plasma membrane invagination", "definition": "An infolding of the plasma membrane. [GOC:dos, GOC:vw]"}
{"concept_id": "C4317071", "aliases": [], "types": ["T043"], "canonical_name": "viral entry into host cell via membrane fusion with the plasma membrane"}
{"concept_id": "C4317072", "aliases": ["viral particle maturation"], "types": ["T043"], "definition": "Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection. [ISBN:0781718325, UniProtKB-KW:KW-0917, VZ:1946]", "canonical_name": "virion maturation"}
{"concept_id": "C4318489", "aliases": ["paraflagellar rod"], "types": ["T026"], "definition": "A large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. Protein components of the paraflagellar rod are likely implicated, among other, in adenine nucleotide signalling and metabolism, and in calcium signalling. [GOC:cilia, PMID:19879876, PMID:26199333, PMID:26688619]", "canonical_name": "PFR"}
{"concept_id": "C4318503", "aliases": ["ciliary vesicle", "primary ciliary vesicle"], "types": ["T026"], "definition": "A Golgi-derived vesicle to which the ciliary basal body docks via its transitional fibers. Its membrane is compositionally distinct from Golgi membranes, and will become the ciliary membrane once the ciliary vesicle is fused to the plasma membrane. The ciliary vesicle is thought to be formed by multiple smaller vesicles that attach to the transitional fibers and then fuse to form a larger vesicle. [GOC:cilia, PMID:13978319, PMID:25686250]", "canonical_name": "CV"}
{"concept_id": "C4318582", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphoric acid. [EC:4.2.3.61, GOC:pz]", "canonical_name": "5-epi-aristolochene synthase activity"}
{"concept_id": "C4318583", "aliases": [], "types": ["T043"], "definition": "The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body. [GOC:dos]", "canonical_name": "anterograde dendritic transport of mitochondrion"}
{"concept_id": "C4318584", "aliases": ["anterograde axonal transport of mitochondrion"], "types": ["T043"], "definition": "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. [GOC:dos]", "canonical_name": "anterograde axon transport of mitochondria"}
{"concept_id": "C4318585", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR). [GOC:dph, GOC:pad, GOC:PARL, PMID:11866528]", "canonical_name": "cyclic ADP-ribose hydrolase"}
{"concept_id": "C4318586", "aliases": [], "types": ["T044"], "canonical_name": "cystatin"}
{"concept_id": "C4318734", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 <=> (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O. [EC:1.14.13.-, GOC:pz]", "canonical_name": "DMNT synthase activity"}
{"concept_id": "C4318735", "aliases": ["establishment of ER localization to postsynapse"], "types": ["T043"], "definition": "The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine. [GOC:dos, PMID:21151132]", "canonical_name": "establishment of endoplasmic reticulum localization to postsynapse"}
{"concept_id": "C4318736", "aliases": ["intramanchette transport"], "types": ["T043"], "definition": "The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments. [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866]", "canonical_name": "IMT"}
{"concept_id": "C4318737", "aliases": ["intrinsic component of dense core granule membrane"], "types": ["T026"], "definition": "The component of the dense core granule membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]", "canonical_name": "intrinsic to dense core granule membrane"}
{"concept_id": "C4318738", "aliases": ["intrinsic to neuronal dense core granule membrane"], "types": ["T026"], "definition": "The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]", "canonical_name": "intrinsic component of neuronal dense core vesicle membrane"}
{"concept_id": "C4318739", "aliases": [], "types": ["T043"], "canonical_name": "L-leucine import into cell"}
{"concept_id": "C4318740", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: (4R)-limonene + O2 + NADH + H+ <=> (4R)-perillyl alcohol + NAD + H2O. [EC:1.14.13.-, GOC:pz]", "canonical_name": "limonene hydroxylase activity"}
{"concept_id": "C4318741", "aliases": ["maintenance of protein location at cell tip"], "types": ["T043"], "definition": "Any process in which localization of a protein is maintained at the cell tip. [GOC:dos, GOC:vw, PMID:12894167]", "canonical_name": "maintenance of protein localization at cell tip"}
{"concept_id": "C4318742", "aliases": ["maintenance of protein localization at growing cell tip"], "types": ["T043"], "definition": "Any process in which localization of a protein is maintained at the growing cell tip. [GOC:dos, GOC:vw, PMID:24146635]", "canonical_name": "maintenance of protein location at growing cell tip"}
{"concept_id": "C4318743", "aliases": [], "types": ["T043"], "definition": "A membrane organization process resulting in the formation of a tubular projection. This may face inwardly (as in tubular membrane invaginations) or outwardly (as in endosomal tubules). [GOC:pr]", "canonical_name": "membrane tubulation"}
{"concept_id": "C4318836", "aliases": [], "types": ["T044"], "canonical_name": "pepsin inhibitor"}
{"concept_id": "C4318837", "aliases": ["perisynaptic ECM", "perisynaptic extracellular matrix"], "types": ["T026"], "definition": "The portion of the extracellular matrix that lies within the perisynaptic space. [GOC:dos]", "canonical_name": "extrasynaptic extracellular matrix"}
{"concept_id": "C4318838", "aliases": ["neurotransmitter receptor transport, postsynaptic endosome to lysosome"], "types": ["T043"], "definition": "The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation. [GOC:dos]", "canonical_name": "postsynaptic neurotransmitter receptor endosomal trafficking"}
{"concept_id": "C4318839", "aliases": ["neurotransmitter receptor transport, endosome to postsynaptic membrane"], "types": ["T043"], "definition": "The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. [GOC:dos]", "canonical_name": "postsynaptic neurotransmitter receptor endosomal trafficking"}
{"concept_id": "C4318840", "aliases": ["retrograde axonal transport of mitochondrion"], "types": ["T043"], "definition": "The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse. [GOC:dos]", "canonical_name": "retrograde axon transport of mitochondria"}
{"concept_id": "C4318841", "aliases": ["retrograde dendrite transport of mitochondria"], "types": ["T043"], "definition": "The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse. [GOC:dos]", "canonical_name": "retrograde dendritic transport of mitochondrion"}
{"concept_id": "C4318842", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. [GOC:pf]", "canonical_name": "RNA polymerase activity"}
{"concept_id": "C4318843", "aliases": ["modification of postsynaptic structure"], "types": ["T043"], "definition": "Any process that modifies the structure of a postsynapse. [GOC:dos]", "canonical_name": "synapse remodelling"}
{"concept_id": "C4318927", "aliases": [], "types": ["T026"], "definition": "A non-membrane bound, electron dense structure associated that extends perpendicular to the presynaptic membrane in ribbon synapses. The ribbon's surface is studded with small particles to which synaptic vesicles tether via fine filaments. The tethered vesicles function as a pool, several fold greater than the docked pool available for fast release, which supports sustained release of vesicles. Synaptic ribbons may be plate like or spherical. [PMID:15626493]", "canonical_name": "synaptic ribbon"}
{"concept_id": "C4318928", "aliases": [], "types": ["T026"], "definition": "A T-shaped presynpatic density. These are common in arhropod central nervous systems. [GOC:dos, PMID:26780543]", "canonical_name": "T-bar"}
{"concept_id": "C4318929", "aliases": [], "types": ["T026"], "canonical_name": "Tenascin-C"}
{"concept_id": "C4318930", "aliases": [], "types": ["T026"], "canonical_name": "Tenascin-R"}
{"concept_id": "C4318931", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: an NDP-alpha-D-glucose + D-glucopyranose <=> alpha,alpha-trehalose + H+ + a nucleoside diphosphate. [EC:2.4.1.245, GOC:pz]", "canonical_name": "trehalose synthase activity"}
{"concept_id": "C4318932", "aliases": ["viral terminase, small subunit"], "types": ["T026"], "definition": "The part of the viral terminase complex that acts as a phage DNA-recognition component and regulates the activity of the large subunit. The small subunit usually assembles as a heterooligomer with the large subunit. [GOC:ch, GOC:jh2, PMID:18687036]", "canonical_name": "virus terminase, small subunit"}
{"concept_id": "C4319101", "aliases": ["regulation of centromeric recombination"], "types": ["T045"], "definition": "Any process that modulates the frequency, rate or extent of DNA recombination within centromeric DNA. [GOC:dph, GOC:mah, PMID:27697832]", "canonical_name": "regulation of DNA recombination at centromere"}
{"concept_id": "C4319102", "aliases": ["negative regulation of centromeric recombination"], "types": ["T045"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination at the centromere. [GOC:dph, GOC:mah]", "canonical_name": "negative regulation of DNA recombination at centromere"}
{"concept_id": "C4319733", "aliases": ["mitochondrion-derived vesicle"], "types": ["T026"], "definition": "A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae. [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:18207745, PMID:20619655, PMID:22226745, PMID:23300790]", "canonical_name": "MDV"}
{"concept_id": "C4321289", "aliases": [], "types": ["T026"], "canonical_name": "Tenascin-X"}
{"concept_id": "C4321528", "aliases": ["sensory perception of itch"], "types": ["T080"], "definition": "A sensory perception which causes the desire or reflex to scratch. [PMID:26015312, PMID:29723501, PMID:30734045, Wikipedia:Itch]", "canonical_name": "pruritus"}
{"concept_id": "C4325592", "aliases": ["down-regulation of motile primary cilia assembly", "downregulation of motile primary cilia assembly", "downregulation of motile primary cilium assembly", "down-regulation of motile primary cilium assembly", "down regulation of motile primary cilium assembly"], "types": ["T043"], "canonical_name": "down regulation of motile primary cilia assembly"}
{"concept_id": "C4325593", "aliases": ["downregulation of cytochrome aa3 activity", "down-regulation of cytochrome aa3 activity"], "types": ["T044"], "canonical_name": "down regulation of cytochrome aa3 activity"}
{"concept_id": "C4325594", "aliases": [], "types": ["T044"], "canonical_name": "distal appendage of mother centriole assembly"}
{"concept_id": "C4325595", "aliases": [], "types": ["T044"], "canonical_name": "activation of prostaglandin breakdown"}
{"concept_id": "C4325596", "aliases": ["vacuolar protein sorting-associated complex location"], "types": ["T026"], "canonical_name": "vacuolar protein sorting-associated complex"}
{"concept_id": "C4325597", "aliases": ["inhibition of protein localization to kinetochore"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to kinetochore"}
{"concept_id": "C4325598", "aliases": ["activation of morphogenesis of an epithelium"], "types": ["T042"], "canonical_name": "activation of epithelium morphogenesis"}
{"concept_id": "C4325599", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synapse organization and biogenesis"}
{"concept_id": "C4325600", "aliases": ["meiotic nuclear division"], "types": ["T043"], "definition": "One of the two nuclear divisions that occur as part of the meiotic cell cycle. [PMID:9334324]", "canonical_name": "meiosis"}
{"concept_id": "C4325602", "aliases": ["iron import into cell"], "types": ["T043"], "canonical_name": "iron import into cell", "definition": "The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. [PMID:18622392, PMID:23192658, Wikipedia:Human_iron_metabolism]"}
{"concept_id": "C4325603", "aliases": [], "types": ["T043"], "canonical_name": "response to DIF1"}
{"concept_id": "C4325604", "aliases": ["nonmotile primary cilia", "immotile primary cilium"], "types": ["T026"], "canonical_name": "nonmotile primary cilium"}
{"concept_id": "C4325605", "aliases": [], "types": ["T026"], "canonical_name": "Las1-Grc3-Rat1-Rai1"}
{"concept_id": "C4325606", "aliases": [], "types": ["T043"], "canonical_name": "microtubule basal body duplication"}
{"concept_id": "C4325607", "aliases": [], "types": ["T044"], "canonical_name": "deglycation of N-acetylarginine"}
{"concept_id": "C4325608", "aliases": [], "types": ["T044"], "canonical_name": "Rad51 nucleoprotein filament disassembly"}
{"concept_id": "C4325609", "aliases": [], "types": ["T043"], "canonical_name": "actin-dependent nuclear movement"}
{"concept_id": "C4325610", "aliases": ["TAN line"], "types": ["T026"], "canonical_name": "transmembrane actin-associated (TAN) line", "definition": "A linear array of nuclear envelope membrane proteins composed of nesprin-2G and SUN2, which couple the nucleus to moving actin cables, resulting in rearward nuclear transport (away from the leading edge). [GOC:hjd, PMID:21173262]"}
{"concept_id": "C4325611", "aliases": ["Platelet glycoprotein Ia* complex location"], "types": ["T026"], "canonical_name": "Platelet glycoprotein Ia* complex"}
{"concept_id": "C4325612", "aliases": ["p155 complex location"], "types": ["T026"], "canonical_name": "p155 complex"}
{"concept_id": "C4325613", "aliases": ["Multimerin-2 complex location"], "types": ["T026"], "canonical_name": "Multimerin-2 complex"}
{"concept_id": "C4325614", "aliases": ["Multimerin-1 complex location"], "types": ["T026"], "canonical_name": "Multimerin-1 complex"}
{"concept_id": "C4325615", "aliases": ["Elastic microfibrillar interface 4 complex", "EMILIN-4 complex location", "Elastic microfibrillar interface 4 complex location"], "types": ["T026"], "canonical_name": "EMILIN-4 complex"}
{"concept_id": "C4325616", "aliases": ["Elastic microfibrillar interface 3 complex location", "EMILIN-3 complex location", "Elastic microfibrillar interface 3 complex"], "types": ["T026"], "canonical_name": "EMILIN-3 complex"}
{"concept_id": "C4325617", "aliases": ["Elastic microfibrillar interface 2 complex location", "Elastic microfibrillar interface 2 complex", "EMILIN-2 complex location"], "types": ["T026"], "canonical_name": "EMILIN-2 complex"}
{"concept_id": "C4325618", "aliases": ["EMILIN-1 complex location", "Elastic microfibrillar interface 1 complex", "Elastic microfibrillar interface 1 complex location"], "types": ["T026"], "canonical_name": "EMILIN-1 complex"}
{"concept_id": "C4325619", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of viral Tat activity"}
{"concept_id": "C4325620", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of viral protein:RNA interaction"}
{"concept_id": "C4325622", "aliases": ["establishment of blood-retina barrier", "establishment of BRB"], "types": ["T043"], "canonical_name": "establishment of blood-retinal barrier", "definition": "Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type. [PMID:25053619]"}
{"concept_id": "C4325623", "aliases": ["VPS4A/B complex", "VPS4A/B complex location"], "types": ["T026"], "canonical_name": "VPS4A-VPS4B"}
{"concept_id": "C4325626", "aliases": ["Palmitoyltransferase ERF2/SHR5 complex", "Palmitoyltransferase ERF2/SHR5 complex location", "Palmitoyltransferase ERF2-SHR5 complex location"], "types": ["T026"], "canonical_name": "Palmitoyltransferase ERF2-SHR5 complex"}
{"concept_id": "C4325627", "aliases": ["response to DIF2", "response to DIF-2", "response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one"], "types": ["T040"], "canonical_name": "response to differentiation-inducing factor 2", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus. [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:19684855, PMID:3355503]"}
{"concept_id": "C4325628", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to alcohol"}
{"concept_id": "C4325629", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to alcohol"}
{"concept_id": "C4325630", "aliases": [], "types": ["T042"], "canonical_name": "activation of endothelial tube morphogenesis"}
{"concept_id": "C4325631", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of endothelial tube morphogenesis"}
{"concept_id": "C4325632", "aliases": ["activation of lipid localization"], "types": ["T039"], "canonical_name": "activation of lipid localisation"}
{"concept_id": "C4325633", "aliases": ["inhibition of lipid localization"], "types": ["T039"], "canonical_name": "inhibition of lipid localisation"}
{"concept_id": "C4325634", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcium ion import across plasma membrane"}
{"concept_id": "C4325635", "aliases": ["activation of response to calcium ion"], "types": ["T039"], "canonical_name": "activation of response to Ca2+ ion"}
{"concept_id": "C4325636", "aliases": ["inhibition of response to calcium ion"], "types": ["T039"], "canonical_name": "inhibition of response to Ca2+ ion"}
{"concept_id": "C4325637", "aliases": [], "types": ["T043"], "canonical_name": "activation of formation of growth cone in injured axon"}
{"concept_id": "C4325638", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of formation of growth cone in injured axon"}
{"concept_id": "C4325639", "aliases": ["activation of gonadogenesis"], "types": ["T042"], "canonical_name": "activation of gonad development"}
{"concept_id": "C4325640", "aliases": ["inhibition of gonadogenesis"], "types": ["T042"], "canonical_name": "inhibition of gonad development"}
{"concept_id": "C4325641", "aliases": [], "types": ["T043"], "canonical_name": "activation of germ cell proliferation"}
{"concept_id": "C4325642", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of germ cell proliferation"}
{"concept_id": "C4325643", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell fate determination"}
{"concept_id": "C4325644", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell fate determination"}
{"concept_id": "C4325645", "aliases": ["upregulation of VSMC differentiation involved in phenotypic dimorphism", "up-regulation of VSMC differentiation involved in phenotypic dimorphism", "up regulation of VSMC differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "positive regulation of VSMC differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325646", "aliases": ["up-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism", "upregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism", "up regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325647", "aliases": ["upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism", "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism", "up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325648", "aliases": ["activation of vascular smooth muscle cell differentiation involved in phenotypic switching"], "types": ["T043"], "canonical_name": "activation of VSMC differentiation involved in phenotypic switching"}
{"concept_id": "C4325649", "aliases": ["activation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "activation of VSMC differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325650", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular associated smooth muscle cell differentiation involved in phenotypic switching"}
{"concept_id": "C4325651", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325652", "aliases": ["negative regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "negative regulation of VSMC differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325653", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325654", "aliases": ["inhibition of vascular smooth muscle cell differentiation involved in phenotypic switching"], "types": ["T043"], "canonical_name": "inhibition of VSMC differentiation involved in phenotypic switching"}
{"concept_id": "C4325655", "aliases": ["inhibition of vascular smooth muscle cell differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "inhibition of VSMC differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325656", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic switching"}
{"concept_id": "C4325657", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325658", "aliases": ["down-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism", "down regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism", "downregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism", "down-regulation of VSMC differentiation involved in phenotypic dimorphism", "downregulation of VSMC differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "down regulation of VSMC differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325659", "aliases": ["down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism", "downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325660", "aliases": ["regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "regulation of VSMC differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325661", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4325668", "aliases": [], "types": ["T044"], "canonical_name": "activation of acetylcholine synthesis"}
{"concept_id": "C4325669", "aliases": [], "types": ["T044"], "canonical_name": "activation of acetylcholine formation"}
{"concept_id": "C4325670", "aliases": [], "types": ["T044"], "canonical_name": "activation of acetylcholine biosynthetic process"}
{"concept_id": "C4325671", "aliases": [], "types": ["T044"], "canonical_name": "activation of acetylcholine biosynthesis"}
{"concept_id": "C4325672", "aliases": [], "types": ["T044"], "canonical_name": "activation of acetylcholine anabolism"}
{"concept_id": "C4325673", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acetylcholine synthesis"}
{"concept_id": "C4325674", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acetylcholine formation"}
{"concept_id": "C4325675", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acetylcholine biosynthetic process"}
{"concept_id": "C4325676", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acetylcholine biosynthesis"}
{"concept_id": "C4325677", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of acetylcholine anabolism"}
{"concept_id": "C4325678", "aliases": [], "types": ["T044"], "canonical_name": "activation of CoA-transferase activity"}
{"concept_id": "C4325679", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CoA-transferase activity"}
{"concept_id": "C4325680", "aliases": [], "types": ["T043"], "canonical_name": "activation of cell differentiation involved in phenotypic switching"}
{"concept_id": "C4325681", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cell differentiation involved in phenotypic switching"}
{"concept_id": "C4325682", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium ion export from cell"}
{"concept_id": "C4325683", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium ion efflux from cell"}
{"concept_id": "C4325684", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcium ion export from cell"}
{"concept_id": "C4325685", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of calcium ion efflux from cell"}
{"concept_id": "C4325686", "aliases": [], "types": ["T040"], "canonical_name": "activation of nematode entry into dormancy"}
{"concept_id": "C4325687", "aliases": [], "types": ["T040"], "canonical_name": "activation of dauer entry"}
{"concept_id": "C4325688", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of nematode entry into dormancy"}
{"concept_id": "C4325689", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of dauer entry"}
{"concept_id": "C4325690", "aliases": ["upregulation of amyloid structure formation", "up-regulation of amyloid structure formation"], "types": ["T044"], "canonical_name": "up regulation of amyloid structure formation"}
{"concept_id": "C4325691", "aliases": ["up-regulation of amyloid structure assembly", "upregulation of amyloid structure assembly"], "types": ["T044"], "canonical_name": "up regulation of amyloid structure assembly"}
{"concept_id": "C4325692", "aliases": ["up-regulation of amyloid fibril assembly", "upregulation of amyloid fibril assembly"], "types": ["T044"], "canonical_name": "up regulation of amyloid fibril assembly"}
{"concept_id": "C4325693", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of amyloid structure formation"}
{"concept_id": "C4325694", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of amyloid structure assembly"}
{"concept_id": "C4325695", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of amyloid fibril assembly"}
{"concept_id": "C4325696", "aliases": [], "types": ["T044"], "canonical_name": "activation of amyloid structure formation"}
{"concept_id": "C4325697", "aliases": [], "types": ["T044"], "canonical_name": "activation of amyloid structure assembly"}
{"concept_id": "C4325698", "aliases": [], "types": ["T044"], "canonical_name": "activation of amyloid fibril formation"}
{"concept_id": "C4325699", "aliases": [], "types": ["T044"], "canonical_name": "activation of amyloid fibril assembly"}
{"concept_id": "C4325700", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of amyloid structure formation"}
{"concept_id": "C4325701", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of amyloid structure assembly"}
{"concept_id": "C4325702", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of amyloid fibril assembly"}
{"concept_id": "C4325703", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amyloid structure formation"}
{"concept_id": "C4325704", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amyloid structure assembly"}
{"concept_id": "C4325705", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amyloid fibril formation"}
{"concept_id": "C4325706", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of amyloid fibril assembly"}
{"concept_id": "C4325707", "aliases": ["down-regulation of amyloid structure formation", "downregulation of amyloid structure formation"], "types": ["T044"], "canonical_name": "down regulation of amyloid structure formation"}
{"concept_id": "C4325708", "aliases": ["downregulation of amyloid structure assembly", "down-regulation of amyloid structure assembly"], "types": ["T044"], "canonical_name": "down regulation of amyloid structure assembly"}
{"concept_id": "C4325709", "aliases": ["down-regulation of amyloid fibril assembly", "downregulation of amyloid fibril assembly"], "types": ["T044"], "canonical_name": "down regulation of amyloid fibril assembly"}
{"concept_id": "C4325710", "aliases": [], "types": ["T044"], "canonical_name": "regulation of amyloid structure formation"}
{"concept_id": "C4325711", "aliases": [], "types": ["T044"], "canonical_name": "regulation of amyloid structure assembly"}
{"concept_id": "C4325712", "aliases": [], "types": ["T044"], "canonical_name": "regulation of amyloid fibril assembly"}
{"concept_id": "C4325713", "aliases": [], "types": ["T042"], "canonical_name": "glandulae pharyngeae morphogenesis"}
{"concept_id": "C4325714", "aliases": [], "types": ["T042"], "canonical_name": "activation of mesoderm formation"}
{"concept_id": "C4325715", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of mesoderm formation"}
{"concept_id": "C4325716", "aliases": [], "types": ["T042"], "canonical_name": "activation of smooth muscle tissue development"}
{"concept_id": "C4325717", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of smooth muscle tissue development"}
{"concept_id": "C4325718", "aliases": ["activation of response to endoplasmic reticulum stress", "activation of response to ER stress"], "types": ["T043"], "canonical_name": "activation of ER stress response"}
{"concept_id": "C4325719", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to endoplasmic reticulum stress"}
{"concept_id": "C4325720", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to tunicamycin"}
{"concept_id": "C4325721", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to tunicamycin"}
{"concept_id": "C4325722", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to thapsigargin"}
{"concept_id": "C4325723", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to thapsigargin"}
{"concept_id": "C4325724", "aliases": ["activation of cellular response to very-low-density lipoprotein particle stimulus"], "types": ["T043"], "canonical_name": "activation of cellular response to VLDL particle stimulus"}
{"concept_id": "C4325725", "aliases": ["inhibition of cellular response to very-low-density lipoprotein particle stimulus"], "types": ["T043"], "canonical_name": "inhibition of cellular response to VLDL particle stimulus"}
{"concept_id": "C4325726", "aliases": [], "types": ["T044"], "canonical_name": "activation of triglyceride transport"}
{"concept_id": "C4325727", "aliases": [], "types": ["T044"], "canonical_name": "activation of triacylglycerol transport"}
{"concept_id": "C4325728", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of triglyceride transport"}
{"concept_id": "C4325729", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of triacylglycerol transport"}
{"concept_id": "C4325730", "aliases": [], "types": ["T043"], "canonical_name": "activation of ovum development"}
{"concept_id": "C4325731", "aliases": [], "types": ["T043"], "canonical_name": "activation of oogenesis"}
{"concept_id": "C4325732", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ovum development"}
{"concept_id": "C4325733", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of oogenesis"}
{"concept_id": "C4325734", "aliases": ["activation of postsynaptic density organization", "activation of postsynaptic density organisation", "activation of post synaptic density organization", "activation of post-synaptic density organization"], "types": ["T043"], "canonical_name": "activation of PSD organization"}
{"concept_id": "C4325735", "aliases": ["inhibition of postsynaptic density organisation", "inhibition of post-synaptic density organization", "inhibition of post synaptic density organization", "inhibition of postsynaptic density organization"], "types": ["T043"], "canonical_name": "inhibition of PSD organization"}
{"concept_id": "C4325736", "aliases": ["activation of protein localization to cell leading edge"], "types": ["T043"], "canonical_name": "activation of protein localisation to cell leading edge"}
{"concept_id": "C4325737", "aliases": ["activation of protein localization in cell leading edge"], "types": ["T043"], "canonical_name": "activation of protein localisation in cell leading edge"}
{"concept_id": "C4325738", "aliases": ["inhibition of protein localization to cell leading edge"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to cell leading edge"}
{"concept_id": "C4325739", "aliases": ["inhibition of protein localization in cell leading edge"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in cell leading edge"}
{"concept_id": "C4325740", "aliases": ["activation of 3'-untranslated region-mediated mRNA stabilization"], "types": ["T045"], "canonical_name": "activation of 3'-UTR-mediated mRNA stabilization"}
{"concept_id": "C4325741", "aliases": ["inhibition of 3'-untranslated region-mediated mRNA stabilization"], "types": ["T045"], "canonical_name": "inhibition of 3'-UTR-mediated mRNA stabilization"}
{"concept_id": "C4325742", "aliases": [], "types": ["T043"], "canonical_name": "activation of ULK1-ATG13-RB1CC1 complex formation"}
{"concept_id": "C4325743", "aliases": [], "types": ["T043"], "canonical_name": "activation of ULK1-ATG13-RB1CC1 complex assembly"}
{"concept_id": "C4325744", "aliases": [], "types": ["T043"], "canonical_name": "activation of ULK1-ATG13-FIP200 complex formation"}
{"concept_id": "C4325745", "aliases": [], "types": ["T043"], "canonical_name": "activation of ULK1-ATG13-FIP200 complex assembly"}
{"concept_id": "C4325746", "aliases": [], "types": ["T043"], "canonical_name": "activation of ULK1 signaling complex formation"}
{"concept_id": "C4325747", "aliases": [], "types": ["T043"], "canonical_name": "activation of ULK1 signaling complex assembly"}
{"concept_id": "C4325748", "aliases": [], "types": ["T043"], "canonical_name": "activation of Atg1p signalling complex formation"}
{"concept_id": "C4325749", "aliases": [], "types": ["T043"], "canonical_name": "activation of Atg1p signalling complex assembly"}
{"concept_id": "C4325750", "aliases": [], "types": ["T043"], "canonical_name": "activation of ATG1/ULK1 signaling complex formation"}
{"concept_id": "C4325751", "aliases": [], "types": ["T043"], "canonical_name": "activation of ATG1/ULK1 signaling complex assembly"}
{"concept_id": "C4325752", "aliases": [], "types": ["T043"], "canonical_name": "activation of ATG1/ULK1 kinase complex formation"}
{"concept_id": "C4325753", "aliases": [], "types": ["T043"], "canonical_name": "activation of ATG1/ULK1 kinase complex assembly"}
{"concept_id": "C4325754", "aliases": [], "types": ["T043"], "canonical_name": "activation of ATG1-ATG13 complex formation"}
{"concept_id": "C4325755", "aliases": [], "types": ["T043"], "canonical_name": "activation of ATG1-ATG13 complex assembly"}
{"concept_id": "C4325756", "aliases": [], "types": ["T043"], "canonical_name": "activation of ATG1 kinase complex formation"}
{"concept_id": "C4325757", "aliases": [], "types": ["T043"], "canonical_name": "activation of ATG1 kinase complex assembly"}
{"concept_id": "C4325758", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ULK1-ATG13-RB1CC1 complex formation"}
{"concept_id": "C4325759", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ULK1-ATG13-RB1CC1 complex assembly"}
{"concept_id": "C4325760", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ULK1-ATG13-FIP200 complex formation"}
{"concept_id": "C4325761", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ULK1-ATG13-FIP200 complex assembly"}
{"concept_id": "C4325762", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ULK1 signaling complex formation"}
{"concept_id": "C4325763", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ULK1 signaling complex assembly"}
{"concept_id": "C4325764", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Atg1p signalling complex formation"}
{"concept_id": "C4325765", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Atg1p signalling complex assembly"}
{"concept_id": "C4325766", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATG1/ULK1 signaling complex formation"}
{"concept_id": "C4325767", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATG1/ULK1 signaling complex assembly"}
{"concept_id": "C4325768", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATG1/ULK1 kinase complex formation"}
{"concept_id": "C4325769", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATG1/ULK1 kinase complex assembly"}
{"concept_id": "C4325770", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATG1-ATG13 complex formation"}
{"concept_id": "C4325771", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATG1-ATG13 complex assembly"}
{"concept_id": "C4325772", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATG1 kinase complex formation"}
{"concept_id": "C4325773", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ATG1 kinase complex assembly"}
{"concept_id": "C4325774", "aliases": ["up-regulation of heparin proteoglycan binding", "upregulation of heparin proteoglycan binding"], "types": ["T044"], "canonical_name": "up regulation of heparin proteoglycan binding"}
{"concept_id": "C4325775", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heparin proteoglycan binding"}
{"concept_id": "C4325776", "aliases": [], "types": ["T044"], "canonical_name": "activation of heparin proteoglycan binding"}
{"concept_id": "C4325777", "aliases": [], "types": ["T044"], "canonical_name": "activation of heparan sulfate proteoglycan binding"}
{"concept_id": "C4325778", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of heparin proteoglycan binding"}
{"concept_id": "C4325779", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heparin proteoglycan binding"}
{"concept_id": "C4325780", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heparan sulfate proteoglycan binding"}
{"concept_id": "C4325781", "aliases": ["downregulation of heparin proteoglycan binding", "down-regulation of heparin proteoglycan binding"], "types": ["T044"], "canonical_name": "down regulation of heparin proteoglycan binding"}
{"concept_id": "C4325782", "aliases": [], "types": ["T044"], "canonical_name": "regulation of heparin proteoglycan binding"}
{"concept_id": "C4325783", "aliases": [], "types": ["T044"], "canonical_name": "activation of heparan sulfate binding"}
{"concept_id": "C4325784", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of heparan sulfate binding"}
{"concept_id": "C4325785", "aliases": [], "types": ["T040"], "canonical_name": "activation of backward locomotion"}
{"concept_id": "C4325786", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of backward locomotion"}
{"concept_id": "C4325787", "aliases": [], "types": ["T040"], "canonical_name": "activation of forward locomotion"}
{"concept_id": "C4325788", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of forward locomotion"}
{"concept_id": "C4325789", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to oxidopamine"}
{"concept_id": "C4325790", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to oxidopamine"}
{"concept_id": "C4325791", "aliases": ["upregulation of cellular response to gamma-ray photon", "up-regulation of cellular response to gamma-ray photon"], "types": ["T043"], "canonical_name": "up regulation of cellular response to gamma-ray photon"}
{"concept_id": "C4325792", "aliases": ["upregulation of cellular response to gamma ray", "up-regulation of cellular response to gamma ray"], "types": ["T043"], "canonical_name": "up regulation of cellular response to gamma ray"}
{"concept_id": "C4325793", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cellular response to gamma-ray photon"}
{"concept_id": "C4325794", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cellular response to gamma ray"}
{"concept_id": "C4325795", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to gamma-ray photon"}
{"concept_id": "C4325796", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to gamma ray"}
{"concept_id": "C4325797", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to gamma radiation"}
{"concept_id": "C4325798", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular response to gamma-ray photon"}
{"concept_id": "C4325799", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular response to gamma ray"}
{"concept_id": "C4325800", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to gamma-ray photon"}
{"concept_id": "C4325801", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to gamma ray"}
{"concept_id": "C4325802", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to gamma radiation"}
{"concept_id": "C4325803", "aliases": ["down-regulation of cellular response to gamma-ray photon", "downregulation of cellular response to gamma-ray photon"], "types": ["T043"], "canonical_name": "down regulation of cellular response to gamma-ray photon"}
{"concept_id": "C4325804", "aliases": ["down-regulation of cellular response to gamma ray", "downregulation of cellular response to gamma ray"], "types": ["T043"], "canonical_name": "down regulation of cellular response to gamma ray"}
{"concept_id": "C4325805", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to gamma-ray photon"}
{"concept_id": "C4325806", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to gamma ray"}
{"concept_id": "C4325807", "aliases": [], "types": ["T045"], "canonical_name": "activation of telomeric D-loop disassembly"}
{"concept_id": "C4325808", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of telomeric D-loop disassembly"}
{"concept_id": "C4325809", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of microtubule nucleation"}
{"concept_id": "C4325810", "aliases": [], "types": ["T043"], "canonical_name": "activation of spindle formation"}
{"concept_id": "C4325811", "aliases": [], "types": ["T043"], "canonical_name": "activation of spindle biosynthesis"}
{"concept_id": "C4325812", "aliases": [], "types": ["T043"], "canonical_name": "activation of spindle assembly"}
{"concept_id": "C4325813", "aliases": [], "types": ["T043"], "canonical_name": "activation of bipolar spindle formation"}
{"concept_id": "C4325814", "aliases": [], "types": ["T043"], "canonical_name": "activation of bipolar spindle biosynthesis"}
{"concept_id": "C4325815", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of spindle formation"}
{"concept_id": "C4325816", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of spindle biosynthesis"}
{"concept_id": "C4325817", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of spindle assembly"}
{"concept_id": "C4325818", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of bipolar spindle formation"}
{"concept_id": "C4325819", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of bipolar spindle biosynthesis"}
{"concept_id": "C4325820", "aliases": [], "types": ["T044"], "canonical_name": "activation of prostaglandin degradation"}
{"concept_id": "C4325821", "aliases": [], "types": ["T044"], "canonical_name": "activation of prostaglandin catabolism"}
{"concept_id": "C4325822", "aliases": [], "types": ["T044"], "canonical_name": "activation of prostaglandin catabolic process"}
{"concept_id": "C4325823", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of prostaglandin degradation"}
{"concept_id": "C4325824", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of prostaglandin catabolism"}
{"concept_id": "C4325825", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of prostaglandin catabolic process"}
{"concept_id": "C4325826", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of prostaglandin breakdown"}
{"concept_id": "C4325827", "aliases": [], "types": ["T043"], "canonical_name": "activation of selenocysteine metabolism"}
{"concept_id": "C4325828", "aliases": [], "types": ["T043"], "canonical_name": "activation of selenocysteine metabolic process"}
{"concept_id": "C4325829", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of selenocysteine metabolism"}
{"concept_id": "C4325830", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of selenocysteine metabolic process"}
{"concept_id": "C4325831", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic sister chromatid arm separation"}
{"concept_id": "C4325832", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic sister chromatid arm separation"}
{"concept_id": "C4325833", "aliases": [], "types": ["T043"], "canonical_name": "activation of nuclear chromosome condensation"}
{"concept_id": "C4325834", "aliases": [], "types": ["T043"], "canonical_name": "activation of eukaryotic chromosome condensation"}
{"concept_id": "C4325835", "aliases": [], "types": ["T043"], "canonical_name": "activation of chromosome condensation"}
{"concept_id": "C4325836", "aliases": ["up-regulation of rDNA separation", "upregulation of rDNA separation"], "types": ["T045"], "canonical_name": "up regulation of rDNA separation"}
{"concept_id": "C4325837", "aliases": ["up-regulation of chromatid release", "upregulation of chromatid release"], "types": ["T045"], "canonical_name": "up regulation of chromatid release"}
{"concept_id": "C4325838", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of rDNA separation"}
{"concept_id": "C4325839", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of chromatid release"}
{"concept_id": "C4325840", "aliases": [], "types": ["T045"], "canonical_name": "activation of rDNA separation"}
{"concept_id": "C4325841", "aliases": [], "types": ["T045"], "canonical_name": "activation of chromosome separation"}
{"concept_id": "C4325842", "aliases": [], "types": ["T045"], "canonical_name": "activation of chromatid release"}
{"concept_id": "C4325843", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of rDNA separation"}
{"concept_id": "C4325844", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of chromatid release"}
{"concept_id": "C4325845", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of rDNA separation"}
{"concept_id": "C4325846", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chromosome separation"}
{"concept_id": "C4325847", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chromatid release"}
{"concept_id": "C4325848", "aliases": ["downregulation of rDNA separation", "down-regulation of rDNA separation"], "types": ["T043"], "canonical_name": "down regulation of rDNA separation"}
{"concept_id": "C4325849", "aliases": ["downregulation of chromatid release", "down-regulation of chromatid release"], "types": ["T043"], "canonical_name": "down regulation of chromatid release"}
{"concept_id": "C4325850", "aliases": [], "types": ["T043"], "canonical_name": "regulation of rDNA separation"}
{"concept_id": "C4325851", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chromatid release"}
{"concept_id": "C4325852", "aliases": ["activation of dorsal/ventral axon guidance", "activation of dorsoventral axon guidance"], "types": ["T043"], "canonical_name": "activation of dorsal-ventral axon guidance"}
{"concept_id": "C4325853", "aliases": [], "types": ["T043"], "canonical_name": "activation of dorsal/ventral axon pathfinding"}
{"concept_id": "C4325854", "aliases": ["inhibition of dorsal/ventral axon guidance", "inhibition of dorsoventral axon guidance"], "types": ["T043"], "canonical_name": "inhibition of dorsal-ventral axon guidance"}
{"concept_id": "C4325855", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dorsal/ventral axon pathfinding"}
{"concept_id": "C4325856", "aliases": ["activation of motor neuron axon guidance"], "types": ["T043"], "canonical_name": "activation of motoneuron axon guidance"}
{"concept_id": "C4325857", "aliases": [], "types": ["T043"], "canonical_name": "activation of motor axon pathfinding"}
{"concept_id": "C4325858", "aliases": [], "types": ["T043"], "canonical_name": "activation of motor axon guidance"}
{"concept_id": "C4325859", "aliases": ["inhibition of motor neuron axon guidance"], "types": ["T043"], "canonical_name": "inhibition of motoneuron axon guidance"}
{"concept_id": "C4325860", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of motor axon pathfinding"}
{"concept_id": "C4325861", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of motor axon guidance"}
{"concept_id": "C4325862", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of excitatory synapse disassembly"}
{"concept_id": "C4325863", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of synapse organization and biogenesis"}
{"concept_id": "C4325864", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of synapse morphogenesis"}
{"concept_id": "C4325865", "aliases": ["inhibition of synapse organization"], "types": ["T043"], "canonical_name": "inhibition of synapse organisation"}
{"concept_id": "C4325866", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synapse morphogenesis"}
{"concept_id": "C4325867", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synapse development"}
{"concept_id": "C4325868", "aliases": ["down-regulation of synapse organization and biogenesis", "downregulation of synapse organization and biogenesis"], "types": ["T043"], "canonical_name": "down regulation of synapse organization and biogenesis"}
{"concept_id": "C4325869", "aliases": ["downregulation of synapse morphogenesis", "down-regulation of synapse morphogenesis"], "types": ["T043"], "canonical_name": "down regulation of synapse morphogenesis"}
{"concept_id": "C4325870", "aliases": [], "types": ["T043"], "canonical_name": "activation of synapse disassembly"}
{"concept_id": "C4325871", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synapse disassembly"}
{"concept_id": "C4325872", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to manganese ion"}
{"concept_id": "C4325873", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular response to manganese"}
{"concept_id": "C4325874", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to manganese ion"}
{"concept_id": "C4325875", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular response to manganese"}
{"concept_id": "C4325876", "aliases": [], "types": ["T043"], "canonical_name": "activation of intraflagellar retrograde transport"}
{"concept_id": "C4325877", "aliases": [], "types": ["T043"], "canonical_name": "activation of intraciliary retrograde transport"}
{"concept_id": "C4325878", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intraflagellar retrograde transport"}
{"concept_id": "C4325879", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intraciliary retrograde transport"}
{"concept_id": "C4325880", "aliases": [], "types": ["T043"], "canonical_name": "activation of intraflagellar anterograde transport"}
{"concept_id": "C4325881", "aliases": [], "types": ["T043"], "canonical_name": "activation of intraciliary anterograde transport"}
{"concept_id": "C4325882", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intraflagellar anterograde transport"}
{"concept_id": "C4325883", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intraciliary anterograde transport"}
{"concept_id": "C4325884", "aliases": ["activation of mechanosensory behaviour"], "types": ["T040"], "canonical_name": "activation of mechanosensory behavior"}
{"concept_id": "C4325885", "aliases": ["activation of behavioural response to mechanical stimulus"], "types": ["T040"], "canonical_name": "activation of behavioral response to mechanical stimulus"}
{"concept_id": "C4325886", "aliases": ["inhibition of mechanosensory behaviour"], "types": ["T040"], "canonical_name": "inhibition of mechanosensory behavior"}
{"concept_id": "C4325887", "aliases": ["inhibition of behavioural response to mechanical stimulus"], "types": ["T040"], "canonical_name": "inhibition of behavioral response to mechanical stimulus"}
{"concept_id": "C4325888", "aliases": [], "types": ["T040"], "canonical_name": "activation of tactition, sensory detection of mechanical stimulus"}
{"concept_id": "C4325889", "aliases": [], "types": ["T040"], "canonical_name": "activation of sensory transduction of mechanical stimulus during perception of touch"}
{"concept_id": "C4325890", "aliases": [], "types": ["T040"], "canonical_name": "activation of sensory detection of mechanical stimulus during perception of touch"}
{"concept_id": "C4325891", "aliases": [], "types": ["T040"], "canonical_name": "activation of perception of touch, sensory transduction of mechanical stimulus"}
{"concept_id": "C4325892", "aliases": [], "types": ["T040"], "canonical_name": "activation of perception of touch, sensory detection of mechanical stimulus"}
{"concept_id": "C4325893", "aliases": [], "types": ["T040"], "canonical_name": "activation of perception of touch, detection of mechanical stimulus"}
{"concept_id": "C4325894", "aliases": [], "types": ["T040"], "canonical_name": "activation of detection of mechanical stimulus involved in sensory perception of touch"}
{"concept_id": "C4325895", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of tactition, sensory detection of mechanical stimulus"}
{"concept_id": "C4325896", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of sensory transduction of mechanical stimulus during perception of touch"}
{"concept_id": "C4325897", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of sensory detection of mechanical stimulus during perception of touch"}
{"concept_id": "C4325898", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of perception of touch, sensory transduction of mechanical stimulus"}
{"concept_id": "C4325899", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of perception of touch, sensory detection of mechanical stimulus"}
{"concept_id": "C4325900", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of perception of touch, detection of mechanical stimulus"}
{"concept_id": "C4325901", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of detection of mechanical stimulus involved in sensory perception of touch"}
{"concept_id": "C4325904", "aliases": [], "types": ["T043"], "canonical_name": "activation of phosphatidylserine exposure on apoptotic cell surface"}
{"concept_id": "C4325905", "aliases": [], "types": ["T043"], "canonical_name": "activation of externalization of phosphatidylserine"}
{"concept_id": "C4325906", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of phosphatidylserine exposure on apoptotic cell surface"}
{"concept_id": "C4325907", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of externalization of phosphatidylserine"}
{"concept_id": "C4325908", "aliases": ["upregulation of exonuclease IX activity", "up-regulation of exonuclease IX activity"], "types": ["T044"], "canonical_name": "up regulation of exonuclease IX activity"}
{"concept_id": "C4325909", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of exonuclease IX activity"}
{"concept_id": "C4325910", "aliases": [], "types": ["T044"], "canonical_name": "activation of exonuclease IX activity"}
{"concept_id": "C4325911", "aliases": [], "types": ["T044"], "canonical_name": "activation of exonuclease activity"}
{"concept_id": "C4325912", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of exonuclease IX activity"}
{"concept_id": "C4325913", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of exonuclease IX activity"}
{"concept_id": "C4325914", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of exonuclease activity"}
{"concept_id": "C4325915", "aliases": ["down-regulation of exonuclease IX activity", "downregulation of exonuclease IX activity"], "types": ["T044"], "canonical_name": "down regulation of exonuclease IX activity"}
{"concept_id": "C4325916", "aliases": [], "types": ["T044"], "canonical_name": "regulation of exonuclease IX activity"}
{"concept_id": "C4325917", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA helicase activity"}
{"concept_id": "C4325918", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DNA helicase activity"}
{"concept_id": "C4325919", "aliases": ["activation of mesodermal cell differentiation"], "types": ["T043"], "canonical_name": "activation of mesoderm cell differentiation"}
{"concept_id": "C4325920", "aliases": ["inhibition of mesodermal cell differentiation"], "types": ["T043"], "canonical_name": "inhibition of mesoderm cell differentiation"}
{"concept_id": "C4325921", "aliases": [], "types": ["T045"], "canonical_name": "activation of double-stranded telomeric DNA binding"}
{"concept_id": "C4325922", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of double-stranded telomeric DNA binding"}
{"concept_id": "C4325923", "aliases": [], "types": ["T045"], "canonical_name": "activation of protection from non-homologous end joining at telomere"}
{"concept_id": "C4325924", "aliases": [], "types": ["T045"], "canonical_name": "activation of protection from NHEJ-mediated telomere fusion"}
{"concept_id": "C4325925", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of protection from non-homologous end joining at telomere"}
{"concept_id": "C4325926", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of protection from NHEJ-mediated telomere fusion"}
{"concept_id": "C4325927", "aliases": [], "types": ["T044"], "canonical_name": "SCF complex substrate recognition subunit binding"}
{"concept_id": "C4325928", "aliases": ["microtubule end of neurotubule of post-anaphase microtubule array", "microtubule end of neurotubule of post-anaphase array"], "types": ["T026"], "canonical_name": "microtubule end of neurotubule of PAA"}
{"concept_id": "C4325929", "aliases": ["neurotubule of post-anaphase microtubule array", "neurotubule of post-anaphase array"], "types": ["T026"], "canonical_name": "neurotubule of PAA"}
{"concept_id": "C4325930", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-citrulline:L-aspartate ligase (AMP-forming)"}
{"concept_id": "C4325931", "aliases": [], "types": ["T044"], "canonical_name": "activation of citrulline--aspartate ligase activity"}
{"concept_id": "C4325932", "aliases": [], "types": ["T044"], "canonical_name": "activation of arginosuccinate synthetase activity"}
{"concept_id": "C4325933", "aliases": [], "types": ["T044"], "canonical_name": "activation of argininosuccinic acid synthetase activity"}
{"concept_id": "C4325934", "aliases": [], "types": ["T044"], "canonical_name": "activation of argininosuccinate synthetase activity"}
{"concept_id": "C4325935", "aliases": [], "types": ["T044"], "canonical_name": "activation of argininosuccinate synthase activity"}
{"concept_id": "C4325936", "aliases": [], "types": ["T044"], "canonical_name": "activation of arginine succinate synthetase activity"}
{"concept_id": "C4325937", "aliases": [], "types": ["T043"], "canonical_name": "activation of endosome to plasma membrane protein transport"}
{"concept_id": "C4325938", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endosome to plasma membrane protein transport"}
{"concept_id": "C4325939", "aliases": ["inhibition of salivation"], "types": ["T042"], "canonical_name": "inhibition of saliva secretion"}
{"concept_id": "C4325940", "aliases": [], "types": ["T045"], "canonical_name": "regulation of splicing"}
{"concept_id": "C4325941", "aliases": [], "types": ["T045"], "canonical_name": "regulation of nuclear mRNA cis splicing, via U2-type spliceosome"}
{"concept_id": "C4325942", "aliases": [], "types": ["T044"], "canonical_name": "activation of trypanothione synthesis"}
{"concept_id": "C4325943", "aliases": [], "types": ["T044"], "canonical_name": "activation of trypanothione formation"}
{"concept_id": "C4325944", "aliases": [], "types": ["T044"], "canonical_name": "activation of trypanothione biosynthetic process"}
{"concept_id": "C4325945", "aliases": [], "types": ["T044"], "canonical_name": "activation of trypanothione biosynthesis"}
{"concept_id": "C4325946", "aliases": [], "types": ["T044"], "canonical_name": "activation of trypanothione anabolism"}
{"concept_id": "C4325947", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of trypanothione synthesis"}
{"concept_id": "C4325948", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of trypanothione formation"}
{"concept_id": "C4325949", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of trypanothione biosynthetic process"}
{"concept_id": "C4325950", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of trypanothione biosynthesis"}
{"concept_id": "C4325951", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of trypanothione anabolism"}
{"concept_id": "C4325952", "aliases": [], "types": ["T043"], "canonical_name": "activation of cornification"}
{"concept_id": "C4325953", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cornification"}
{"concept_id": "C4325954", "aliases": [], "types": ["T043"], "canonical_name": "regulation of shmooing"}
{"concept_id": "C4325955", "aliases": [], "types": ["T043"], "canonical_name": "regulation of shmoo orientation"}
{"concept_id": "C4325956", "aliases": [], "types": ["T043"], "canonical_name": "activation of inhibitory synapse formation"}
{"concept_id": "C4325957", "aliases": [], "types": ["T043"], "canonical_name": "activation of inhibitory synapse assembly"}
{"concept_id": "C4325958", "aliases": ["inhibition of inhibitory synapse formation"], "types": ["T043"], "canonical_name": "inhibition of inhibitory synapse assembly"}
{"concept_id": "C4325959", "aliases": [], "types": ["T043"], "canonical_name": "activation of drug transmembrane export"}
{"concept_id": "C4325960", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of drug transmembrane export"}
{"concept_id": "C4325961", "aliases": [], "types": ["T044"], "canonical_name": "activation of polysome binding"}
{"concept_id": "C4325962", "aliases": [], "types": ["T044"], "canonical_name": "activation of polyribosome binding"}
{"concept_id": "C4325963", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polysome binding"}
{"concept_id": "C4325964", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of polyribosome binding"}
{"concept_id": "C4325965", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidic acid synthesis"}
{"concept_id": "C4325966", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidic acid formation"}
{"concept_id": "C4325967", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidic acid biosynthetic process"}
{"concept_id": "C4325968", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidic acid biosynthesis"}
{"concept_id": "C4325969", "aliases": [], "types": ["T044"], "canonical_name": "activation of phosphatidic acid anabolism"}
{"concept_id": "C4325970", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidic acid synthesis"}
{"concept_id": "C4325971", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidic acid formation"}
{"concept_id": "C4325972", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidic acid biosynthetic process"}
{"concept_id": "C4325973", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidic acid biosynthesis"}
{"concept_id": "C4325974", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of phosphatidic acid anabolism"}
{"concept_id": "C4325975", "aliases": ["up-regulation of diacylglycerol:ATP kinase activity", "upregulation of diacylglycerol:ATP kinase activity"], "types": ["T044"], "canonical_name": "up regulation of diacylglycerol:ATP kinase activity"}
{"concept_id": "C4325976", "aliases": ["upregulation of CTP:diacylglycerol kinase activity", "up-regulation of CTP:diacylglycerol kinase activity"], "types": ["T044"], "canonical_name": "up regulation of CTP:diacylglycerol kinase activity"}
{"concept_id": "C4325977", "aliases": ["up-regulation of ATP:diacylglycerol phosphotransferase activity", "upregulation of ATP:diacylglycerol phosphotransferase activity"], "types": ["T044"], "canonical_name": "up regulation of ATP:diacylglycerol phosphotransferase activity"}
{"concept_id": "C4325978", "aliases": ["upregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity", "up-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity"], "types": ["T044"], "canonical_name": "up regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity"}
{"concept_id": "C4325979", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of diacylglycerol:ATP kinase activity"}
{"concept_id": "C4325980", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of CTP:diacylglycerol kinase activity"}
{"concept_id": "C4325981", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ATP:diacylglycerol phosphotransferase activity"}
{"concept_id": "C4325982", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity"}
{"concept_id": "C4325983", "aliases": [], "types": ["T044"], "canonical_name": "activation of sn-1,2-diacylglycerol kinase activity"}
{"concept_id": "C4325984", "aliases": [], "types": ["T044"], "canonical_name": "activation of diglyceride kinase activity"}
{"concept_id": "C4325985", "aliases": [], "types": ["T044"], "canonical_name": "activation of diacylglycerol:ATP kinase activity"}
{"concept_id": "C4325986", "aliases": [], "types": ["T044"], "canonical_name": "activation of diacylglycerol kinase activity"}
{"concept_id": "C4325987", "aliases": [], "types": ["T044"], "canonical_name": "activation of DGK activity"}
{"concept_id": "C4325988", "aliases": [], "types": ["T044"], "canonical_name": "activation of DG kinase activity"}
{"concept_id": "C4325989", "aliases": [], "types": ["T044"], "canonical_name": "activation of CTP:diacylglycerol kinase activity"}
{"concept_id": "C4325990", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATP:diacylglycerol phosphotransferase activity"}
{"concept_id": "C4325991", "aliases": [], "types": ["T044"], "canonical_name": "activation of ATP:1,2-diacylglycerol 3-phosphotransferase activity"}
{"concept_id": "C4325992", "aliases": [], "types": ["T044"], "canonical_name": "activation of arachidonoyl-specific diacylglycerol kinase activity"}
{"concept_id": "C4325993", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1,2-diacylglycerol kinase activity"}
{"concept_id": "C4325994", "aliases": [], "types": ["T044"], "canonical_name": "activation of 1,2-diacylglycerol kinase (phosphorylating)"}
{"concept_id": "C4325995", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of diacylglycerol:ATP kinase activity"}
{"concept_id": "C4325996", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of CTP:diacylglycerol kinase activity"}
{"concept_id": "C4325997", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ATP:diacylglycerol phosphotransferase activity"}
{"concept_id": "C4325998", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity"}
{"concept_id": "C4325999", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of sn-1,2-diacylglycerol kinase activity"}
{"concept_id": "C4326000", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of diglyceride kinase activity"}
{"concept_id": "C4326001", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of diacylglycerol:ATP kinase activity"}
{"concept_id": "C4326002", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of diacylglycerol kinase activity"}
{"concept_id": "C4326003", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DGK activity"}
{"concept_id": "C4326004", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of DG kinase activity"}
{"concept_id": "C4326005", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CTP:diacylglycerol kinase activity"}
{"concept_id": "C4326006", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATP:diacylglycerol phosphotransferase activity"}
{"concept_id": "C4326007", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ATP:1,2-diacylglycerol 3-phosphotransferase activity"}
{"concept_id": "C4326008", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of arachidonoyl-specific diacylglycerol kinase activity"}
{"concept_id": "C4326009", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1,2-diacylglycerol kinase activity"}
{"concept_id": "C4326010", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of 1,2-diacylglycerol kinase (phosphorylating)"}
{"concept_id": "C4326011", "aliases": ["downregulation of diacylglycerol:ATP kinase activity", "down-regulation of diacylglycerol:ATP kinase activity"], "types": ["T044"], "canonical_name": "down regulation of diacylglycerol:ATP kinase activity"}
{"concept_id": "C4326012", "aliases": ["downregulation of CTP:diacylglycerol kinase activity", "down-regulation of CTP:diacylglycerol kinase activity"], "types": ["T044"], "canonical_name": "down regulation of CTP:diacylglycerol kinase activity"}
{"concept_id": "C4326013", "aliases": ["down-regulation of ATP:diacylglycerol phosphotransferase activity", "downregulation of ATP:diacylglycerol phosphotransferase activity"], "types": ["T044"], "canonical_name": "down regulation of ATP:diacylglycerol phosphotransferase activity"}
{"concept_id": "C4326014", "aliases": ["down-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity", "downregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity"], "types": ["T044"], "canonical_name": "down regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity"}
{"concept_id": "C4326015", "aliases": [], "types": ["T044"], "canonical_name": "regulation of diacylglycerol:ATP kinase activity"}
{"concept_id": "C4326016", "aliases": [], "types": ["T044"], "canonical_name": "regulation of CTP:diacylglycerol kinase activity"}
{"concept_id": "C4326017", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ATP:diacylglycerol phosphotransferase activity"}
{"concept_id": "C4326018", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity"}
{"concept_id": "C4326019", "aliases": [], "types": ["T043"], "canonical_name": "activation of plasma membrane repair"}
{"concept_id": "C4326020", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of plasma membrane repair"}
{"concept_id": "C4326021", "aliases": ["peroxisomal disassembly"], "types": ["T043"], "canonical_name": "peroxisome disassembly", "definition": "The disaggregation of a peroxisome into its constituent components. [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C4326022", "aliases": [], "types": ["T040"], "canonical_name": "activation of innate immunity memory response"}
{"concept_id": "C4326023", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of innate immunity memory response"}
{"concept_id": "C4326024", "aliases": [], "types": ["T040"], "canonical_name": "activation of adaptive immune effector response"}
{"concept_id": "C4326025", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of adaptive immune effector response"}
{"concept_id": "C4326026", "aliases": [], "types": ["T040"], "canonical_name": "activation of adaptive immune memory response"}
{"concept_id": "C4326027", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of adaptive immune memory response"}
{"concept_id": "C4326028", "aliases": ["up regulation of lysosome organization and biogenesis", "up-regulation of lysosome organization and biogenesis", "upregulation of lysosome organization and biogenesis"], "types": ["T043"], "canonical_name": "positive regulation of lysosome organization and biogenesis"}
{"concept_id": "C4326029", "aliases": [], "types": ["T043"], "canonical_name": "activation of lysosome organization and biogenesis"}
{"concept_id": "C4326030", "aliases": ["activation of lysosome organization"], "types": ["T043"], "canonical_name": "activation of lysosome organisation"}
{"concept_id": "C4326031", "aliases": ["downregulation of lysosome organization and biogenesis", "down-regulation of lysosome organization and biogenesis", "negative regulation of lysosome organization and biogenesis"], "types": ["T043"], "canonical_name": "down regulation of lysosome organization and biogenesis"}
{"concept_id": "C4326032", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lysosome organization and biogenesis"}
{"concept_id": "C4326033", "aliases": ["inhibition of lysosome organization"], "types": ["T043"], "canonical_name": "inhibition of lysosome organisation"}
{"concept_id": "C4326034", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lysosome organization and biogenesis"}
{"concept_id": "C4326035", "aliases": [], "types": ["T044"], "canonical_name": "mTORC2 disassembly"}
{"concept_id": "C4326036", "aliases": [], "types": ["T044"], "canonical_name": "mTORC1 formation"}
{"concept_id": "C4326037", "aliases": [], "types": ["T044"], "canonical_name": "mTORC1 assembly"}
{"concept_id": "C4326038", "aliases": [], "types": ["T044"], "canonical_name": "dTORC1 formation"}
{"concept_id": "C4326039", "aliases": [], "types": ["T044"], "canonical_name": "dTORC1 assembly"}
{"concept_id": "C4326040", "aliases": [], "types": ["T044"], "canonical_name": "dTOR/dRaptor complex formation"}
{"concept_id": "C4326041", "aliases": [], "types": ["T044"], "canonical_name": "dTOR/dRaptor complex assembly"}
{"concept_id": "C4326042", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein localization to endosome"}
{"concept_id": "C4326043", "aliases": ["activation of protein localization in endosome"], "types": ["T043"], "canonical_name": "activation of protein localisation in endosome"}
{"concept_id": "C4326044", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein localization to endosome"}
{"concept_id": "C4326045", "aliases": ["inhibition of protein localization in endosome"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in endosome"}
{"concept_id": "C4326046", "aliases": [], "types": ["T043"], "canonical_name": "activation of calcium ion import across plasma membrane"}
{"concept_id": "C4326047", "aliases": [], "types": ["T044"], "canonical_name": "activation of telomerase, catalyst"}
{"concept_id": "C4326048", "aliases": [], "types": ["T044"], "canonical_name": "activation of telomerase RNA reverse transcriptase activity"}
{"concept_id": "C4326049", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of telomerase, catalyst"}
{"concept_id": "C4326050", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of telomerase RNA reverse transcriptase activity"}
{"concept_id": "C4326051", "aliases": [], "types": ["T042"], "canonical_name": "activation of artery smooth muscle contraction"}
{"concept_id": "C4326052", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of artery smooth muscle contraction"}
{"concept_id": "C4326053", "aliases": ["activation of arteriogenesis", "activation of artery morphogenesis"], "types": ["T042"], "canonical_name": "activation of arterial morphogenesis"}
{"concept_id": "C4326054", "aliases": ["inhibition of arteriogenesis", "inhibition of artery morphogenesis"], "types": ["T042"], "canonical_name": "inhibition of arterial morphogenesis"}
{"concept_id": "C4326055", "aliases": [], "types": ["T042"], "canonical_name": "activation of shell calcification"}
{"concept_id": "C4326056", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of shell calcification"}
{"concept_id": "C4326057", "aliases": [], "types": ["T043"], "canonical_name": "activation of FACT complex formation"}
{"concept_id": "C4326058", "aliases": ["activation of Facilitates chromatin transcription complex assembly"], "types": ["T043"], "canonical_name": "activation of FACT complex assembly"}
{"concept_id": "C4326059", "aliases": ["inhibition of FACT complex formation"], "types": ["T043"], "canonical_name": "activation of Facilitates chromatin transcription complex formation"}
{"concept_id": "C4326060", "aliases": ["inhibition of Facilitates chromatin transcription complex assembly"], "types": ["T043"], "canonical_name": "inhibition of FACT complex assembly"}
{"concept_id": "C4326061", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Facilitates chromatin transcription complex formation"}
{"concept_id": "C4326062", "aliases": [], "types": ["T044"], "canonical_name": "activation of DNA methylation"}
{"concept_id": "C4326063", "aliases": [], "types": ["T044"], "canonical_name": "activation of mitochondrial mRNA catabolic process"}
{"concept_id": "C4326064", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mitochondrial mRNA catabolic process"}
{"concept_id": "C4326065", "aliases": [], "types": ["T045"], "canonical_name": "activation of RNA polymerase II regulatory region sequence-specific DNA binding"}
{"concept_id": "C4326066", "aliases": [], "types": ["T043"], "canonical_name": "activation of serotonin synthesis"}
{"concept_id": "C4326067", "aliases": [], "types": ["T043"], "canonical_name": "activation of serotonin formation"}
{"concept_id": "C4326068", "aliases": [], "types": ["T043"], "canonical_name": "activation of serotonin biosynthetic process"}
{"concept_id": "C4326069", "aliases": [], "types": ["T043"], "canonical_name": "activation of serotonin biosynthesis"}
{"concept_id": "C4326070", "aliases": [], "types": ["T043"], "canonical_name": "activation of serotonin anabolism"}
{"concept_id": "C4326071", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of serotonin synthesis"}
{"concept_id": "C4326072", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of serotonin formation"}
{"concept_id": "C4326073", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of serotonin biosynthetic process"}
{"concept_id": "C4326074", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of serotonin biosynthesis"}
{"concept_id": "C4326075", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of serotonin anabolism"}
{"concept_id": "C4326076", "aliases": [], "types": ["T039"], "canonical_name": "activation of leaf development"}
{"concept_id": "C4326077", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of leaf development"}
{"concept_id": "C4326078", "aliases": ["activation of alpha-1,3-fucosyltransferase activity", "activation of alpha-(1->3)-fucosyltransferase activity", "activation of alpha-(1,3)-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "activation of alpha(1,3)-fucosyltransferase activity"}
{"concept_id": "C4326079", "aliases": ["inhibition of alpha-(1->3)-fucosyltransferase activity", "inhibition of alpha-(1,3)-fucosyltransferase activity", "inhibition of alpha-1,3-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "inhibition of alpha(1,3)-fucosyltransferase activity"}
{"concept_id": "C4326103", "aliases": [], "types": ["T040"], "canonical_name": "activation of developmental vegetative growth"}
{"concept_id": "C4326104", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of developmental vegetative growth"}
{"concept_id": "C4326105", "aliases": [], "types": ["T044"], "canonical_name": "activation of mRNA cap binding"}
{"concept_id": "C4326106", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of mRNA cap binding"}
{"concept_id": "C4326107", "aliases": [], "types": ["T043"], "canonical_name": "activation of smooth muscle cell-matrix adhesion"}
{"concept_id": "C4326108", "aliases": [], "types": ["T043"], "canonical_name": "activation of presynaptic terminal assembly"}
{"concept_id": "C4326109", "aliases": [], "types": ["T043"], "canonical_name": "activation of presynapse biogenesis"}
{"concept_id": "C4326110", "aliases": [], "types": ["T043"], "canonical_name": "activation of presynapse assembly"}
{"concept_id": "C4326111", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of presynaptic terminal assembly"}
{"concept_id": "C4326112", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of presynapse biogenesis"}
{"concept_id": "C4326113", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of presynapse assembly"}
{"concept_id": "C4326114", "aliases": ["activation of maintenance of permeability of blood-brain barrier"], "types": ["T039"], "canonical_name": "activation of maintenance of permeability of BBB"}
{"concept_id": "C4326115", "aliases": ["inhibition of maintenance of permeability of blood-brain barrier"], "types": ["T039"], "canonical_name": "inhibition of maintenance of permeability of BBB"}
{"concept_id": "C4326116", "aliases": ["upregulation of receptor-mediated endocytosis of LDL", "up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport", "upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport", "up regulation of receptor-mediated endocytosis of LDL", "up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport", "up-regulation of receptor-mediated endocytosis of LDL"], "types": ["T043"], "canonical_name": "positive regulation of receptor-mediated endocytosis of LDL", "definition": "OBSOLETE. Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4326117", "aliases": ["up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport", "upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"], "types": ["T043"], "canonical_name": "up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"}
{"concept_id": "C4326118", "aliases": ["upregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport", "up-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport"], "types": ["T043"], "canonical_name": "up regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport"}
{"concept_id": "C4326119", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport"}
{"concept_id": "C4326120", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"}
{"concept_id": "C4326121", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport"}
{"concept_id": "C4326122", "aliases": [], "types": ["T043"], "canonical_name": "activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport"}
{"concept_id": "C4326123", "aliases": [], "types": ["T043"], "canonical_name": "activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"}
{"concept_id": "C4326124", "aliases": [], "types": ["T043"], "canonical_name": "activation of receptor-mediated endocytosis of LDL"}
{"concept_id": "C4326125", "aliases": [], "types": ["T043"], "canonical_name": "activation of receptor-mediated endocytosis involved in intracellular cholesterol transport"}
{"concept_id": "C4326126", "aliases": [], "types": ["T043"], "canonical_name": "activation of receptor-mediated endocytosis involved in cholesterol transport"}
{"concept_id": "C4326127", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport"}
{"concept_id": "C4326128", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"}
{"concept_id": "C4326129", "aliases": ["down-regulation of receptor-mediated endocytosis of LDL", "down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport", "downregulation of receptor-mediated endocytosis of LDL", "down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport", "negative regulation of receptor-mediated endocytosis of LDL", "downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport"], "types": ["T043"], "canonical_name": "down regulation of receptor-mediated endocytosis of LDL", "definition": "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4326130", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport"}
{"concept_id": "C4326131", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport"}
{"concept_id": "C4326132", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"}
{"concept_id": "C4326133", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of receptor-mediated endocytosis of LDL"}
{"concept_id": "C4326134", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of receptor-mediated endocytosis involved in intracellular cholesterol transport"}
{"concept_id": "C4326135", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of receptor-mediated endocytosis involved in cholesterol transport"}
{"concept_id": "C4326136", "aliases": ["down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport", "downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"], "types": ["T043"], "canonical_name": "down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"}
{"concept_id": "C4326137", "aliases": ["down-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport", "downregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport"], "types": ["T043"], "canonical_name": "down regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport"}
{"concept_id": "C4326138", "aliases": [], "types": ["T043"], "canonical_name": "regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport"}
{"concept_id": "C4326139", "aliases": [], "types": ["T043"], "canonical_name": "regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport"}
{"concept_id": "C4326140", "aliases": [], "types": ["T043"], "canonical_name": "regulation of receptor-mediated endocytosis of LDL", "definition": "OBSOLETE. Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4326141", "aliases": [], "types": ["T043"], "canonical_name": "regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport"}
{"concept_id": "C4326142", "aliases": [], "types": ["T044"], "canonical_name": "activation of low-density lipoprotein receptor activity"}
{"concept_id": "C4326143", "aliases": [], "types": ["T044"], "canonical_name": "activation of LDLR activity"}
{"concept_id": "C4326144", "aliases": [], "types": ["T044"], "canonical_name": "activation of LDL receptor"}
{"concept_id": "C4326145", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of low-density lipoprotein receptor activity"}
{"concept_id": "C4326146", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of LDLR activity"}
{"concept_id": "C4326147", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of LDL receptor"}
{"concept_id": "C4326148", "aliases": ["activation of low-density lipoprotein receptor binding"], "types": ["T044"], "canonical_name": "activation of LDL receptor binding"}
{"concept_id": "C4326149", "aliases": [], "types": ["T044"], "canonical_name": "activation of low-density lipoprotein particle receptor binding"}
{"concept_id": "C4326150", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of low-density lipoprotein receptor binding"}
{"concept_id": "C4326151", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of low-density lipoprotein particle receptor binding"}
{"concept_id": "C4326152", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of LDL receptor binding"}
{"concept_id": "C4326153", "aliases": [], "types": ["T043"], "canonical_name": "activation of optical nerve axon regeneration"}
{"concept_id": "C4326154", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of optical nerve axon regeneration"}
{"concept_id": "C4326155", "aliases": [], "types": ["T043"], "canonical_name": "activation of L-arginine import across plasma membrane"}
{"concept_id": "C4326156", "aliases": ["up-regulation of outer hair cell apoptosis", "upregulation of outer hair cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of outer hair cell apoptosis"}
{"concept_id": "C4326157", "aliases": ["upregulation of cochlear outer hair cell apoptosis", "up-regulation of cochlear outer hair cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of cochlear outer hair cell apoptosis"}
{"concept_id": "C4326158", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of outer hair cell apoptosis"}
{"concept_id": "C4326159", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cochlear outer hair cell apoptosis"}
{"concept_id": "C4326160", "aliases": [], "types": ["T043"], "canonical_name": "activation of outer hair cell apoptotic process"}
{"concept_id": "C4326161", "aliases": [], "types": ["T043"], "canonical_name": "activation of outer hair cell apoptosis"}
{"concept_id": "C4326162", "aliases": ["activation of cochlear outer hair cell apoptotic process"], "types": ["T043"], "canonical_name": "activation of cochlear outer hair cell apoptosis"}
{"concept_id": "C4326163", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of outer hair cell apoptosis"}
{"concept_id": "C4326164", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cochlear outer hair cell apoptosis"}
{"concept_id": "C4326165", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of outer hair cell apoptotic process"}
{"concept_id": "C4326166", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of outer hair cell apoptosis"}
{"concept_id": "C4326167", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cochlear outer hair cell apoptotic process"}
{"concept_id": "C4326168", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cochlear outer hair cell apoptosis"}
{"concept_id": "C4326169", "aliases": ["down-regulation of outer hair cell apoptosis", "downregulation of outer hair cell apoptosis"], "types": ["T043"], "canonical_name": "down regulation of outer hair cell apoptosis"}
{"concept_id": "C4326170", "aliases": ["downregulation of cochlear outer hair cell apoptosis", "down-regulation of cochlear outer hair cell apoptosis"], "types": ["T043"], "canonical_name": "down regulation of cochlear outer hair cell apoptosis"}
{"concept_id": "C4326171", "aliases": [], "types": ["T043"], "canonical_name": "regulation of outer hair cell apoptosis"}
{"concept_id": "C4326172", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cochlear outer hair cell apoptosis"}
{"concept_id": "C4326173", "aliases": [], "types": ["T043"], "canonical_name": "outer hair cell apoptosis"}
{"concept_id": "C4326174", "aliases": [], "types": ["T043"], "canonical_name": "cochlear outer hair cell apoptosis"}
{"concept_id": "C4326175", "aliases": [], "types": ["T043"], "canonical_name": "activation of low-density lipoprotein particle clearance"}
{"concept_id": "C4326176", "aliases": [], "types": ["T043"], "canonical_name": "activation of LDL clearance"}
{"concept_id": "C4326177", "aliases": [], "types": ["T043"], "canonical_name": "activation of receptor tyrosine-protein kinase erbB-3 signaling pathway"}
{"concept_id": "C4326178", "aliases": [], "types": ["T043"], "canonical_name": "activation of HER3 signaling pathway"}
{"concept_id": "C4326179", "aliases": ["activation of ERBB3 signalling pathway"], "types": ["T044"], "canonical_name": "activation of ERBB3 signaling pathway"}
{"concept_id": "C4326180", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of receptor tyrosine-protein kinase erbB-3 signaling pathway"}
{"concept_id": "C4326181", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of HER3 signaling pathway"}
{"concept_id": "C4326182", "aliases": ["inhibition of ERBB3 signalling pathway"], "types": ["T044"], "canonical_name": "inhibition of ERBB3 signaling pathway"}
{"concept_id": "C4326183", "aliases": ["upregulation of ferrichrome biosynthetic process, peptide modification", "up-regulation of ferrichrome biosynthetic process, peptide modification"], "types": ["T043"], "canonical_name": "up regulation of ferrichrome biosynthetic process, peptide modification"}
{"concept_id": "C4326184", "aliases": ["up-regulation of ferrichrome biosynthetic process, peptide formation", "upregulation of ferrichrome biosynthetic process, peptide formation"], "types": ["T043"], "canonical_name": "up regulation of ferrichrome biosynthetic process, peptide formation"}
{"concept_id": "C4326185", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ferrichrome biosynthetic process, peptide modification"}
{"concept_id": "C4326186", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ferrichrome biosynthetic process, peptide formation"}
{"concept_id": "C4326187", "aliases": [], "types": ["T043"], "canonical_name": "activation of ferrichrome synthesis"}
{"concept_id": "C4326188", "aliases": [], "types": ["T043"], "canonical_name": "activation of ferrichrome formation"}
{"concept_id": "C4326189", "aliases": [], "types": ["T043"], "canonical_name": "activation of ferrichrome biosynthetic process, peptide modification"}
{"concept_id": "C4326190", "aliases": [], "types": ["T043"], "canonical_name": "activation of ferrichrome biosynthetic process, peptide formation"}
{"concept_id": "C4326191", "aliases": [], "types": ["T043"], "canonical_name": "activation of ferrichrome biosynthetic process"}
{"concept_id": "C4326192", "aliases": [], "types": ["T043"], "canonical_name": "activation of ferrichrome biosynthesis"}
{"concept_id": "C4326193", "aliases": [], "types": ["T043"], "canonical_name": "activation of ferrichrome anabolism"}
{"concept_id": "C4326194", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ferrichrome biosynthetic process, peptide modification"}
{"concept_id": "C4326195", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ferrichrome biosynthetic process, peptide formation"}
{"concept_id": "C4326196", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ferrichrome synthesis"}
{"concept_id": "C4326197", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ferrichrome formation"}
{"concept_id": "C4326198", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ferrichrome biosynthetic process, peptide modification"}
{"concept_id": "C4326199", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ferrichrome biosynthetic process, peptide formation"}
{"concept_id": "C4326200", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ferrichrome biosynthetic process"}
{"concept_id": "C4326201", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ferrichrome biosynthesis"}
{"concept_id": "C4326202", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of ferrichrome anabolism"}
{"concept_id": "C4326203", "aliases": ["downregulation of ferrichrome biosynthetic process, peptide modification", "down-regulation of ferrichrome biosynthetic process, peptide modification"], "types": ["T043"], "canonical_name": "down regulation of ferrichrome biosynthetic process, peptide modification"}
{"concept_id": "C4326204", "aliases": ["downregulation of ferrichrome biosynthetic process, peptide formation", "down-regulation of ferrichrome biosynthetic process, peptide formation"], "types": ["T043"], "canonical_name": "down regulation of ferrichrome biosynthetic process, peptide formation"}
{"concept_id": "C4326205", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ferrichrome biosynthetic process, peptide modification"}
{"concept_id": "C4326206", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ferrichrome biosynthetic process, peptide formation"}
{"concept_id": "C4326207", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular endothelial cell proliferation"}
{"concept_id": "C4326208", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vascular endothelial cell proliferation"}
{"concept_id": "C4326209", "aliases": ["up-regulation of kinetochore formation", "upregulation of kinetochore formation"], "types": ["T043"], "canonical_name": "up regulation of kinetochore formation"}
{"concept_id": "C4326210", "aliases": ["upregulation of chromosome-kinetochore attachment", "up-regulation of chromosome-kinetochore attachment"], "types": ["T043"], "canonical_name": "up regulation of chromosome-kinetochore attachment"}
{"concept_id": "C4326211", "aliases": ["upregulation of centromere/kinetochore complex maturation", "up-regulation of centromere and kinetochore complex maturation", "up-regulation of centromere/kinetochore complex maturation", "up regulation of centromere/kinetochore complex maturation", "upregulation of centromere and kinetochore complex maturation"], "types": ["T043"], "canonical_name": "up regulation of centromere and kinetochore complex maturation"}
{"concept_id": "C4326212", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of kinetochore formation"}
{"concept_id": "C4326213", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of chromosome-kinetochore attachment"}
{"concept_id": "C4326214", "aliases": ["positive regulation of centromere/kinetochore complex maturation"], "types": ["T043"], "canonical_name": "positive regulation of centromere and kinetochore complex maturation"}
{"concept_id": "C4326215", "aliases": ["activation of kinetochore formation"], "types": ["T043"], "canonical_name": "activation of kinetochore assembly"}
{"concept_id": "C4326216", "aliases": [], "types": ["T043"], "canonical_name": "activation of chromosome-kinetochore attachment"}
{"concept_id": "C4326217", "aliases": ["activation of centromere/kinetochore complex maturation"], "types": ["T043"], "canonical_name": "activation of centromere and kinetochore complex maturation"}
{"concept_id": "C4326218", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of kinetochore formation"}
{"concept_id": "C4326219", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of chromosome-kinetochore attachment"}
{"concept_id": "C4326220", "aliases": ["negative regulation of centromere/kinetochore complex maturation"], "types": ["T043"], "canonical_name": "negative regulation of centromere and kinetochore complex maturation"}
{"concept_id": "C4326221", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of kinetochore formation"}
{"concept_id": "C4326222", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of kinetochore assembly"}
{"concept_id": "C4326223", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chromosome-kinetochore attachment"}
{"concept_id": "C4326224", "aliases": ["inhibition of centromere/kinetochore complex maturation"], "types": ["T043"], "canonical_name": "inhibition of centromere and kinetochore complex maturation"}
{"concept_id": "C4326225", "aliases": ["downregulation of kinetochore formation", "down-regulation of kinetochore formation"], "types": ["T043"], "canonical_name": "down regulation of kinetochore formation"}
{"concept_id": "C4326226", "aliases": ["down-regulation of chromosome-kinetochore attachment", "downregulation of chromosome-kinetochore attachment"], "types": ["T043"], "canonical_name": "down regulation of chromosome-kinetochore attachment"}
{"concept_id": "C4326227", "aliases": ["downregulation of centromere and kinetochore complex maturation", "down regulation of centromere/kinetochore complex maturation", "down-regulation of centromere and kinetochore complex maturation", "downregulation of centromere/kinetochore complex maturation", "down-regulation of centromere/kinetochore complex maturation"], "types": ["T043"], "canonical_name": "down regulation of centromere and kinetochore complex maturation"}
{"concept_id": "C4326228", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic nuclear envelope disassembly"}
{"concept_id": "C4326229", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic nuclear envelope degradation"}
{"concept_id": "C4326230", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic nuclear envelope catabolism"}
{"concept_id": "C4326231", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitotic nuclear envelope breakdown"}
{"concept_id": "C4326232", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic nuclear envelope disassembly"}
{"concept_id": "C4326233", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic nuclear envelope degradation"}
{"concept_id": "C4326234", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic nuclear envelope catabolism"}
{"concept_id": "C4326235", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic nuclear envelope breakdown"}
{"concept_id": "C4326236", "aliases": [], "types": ["T043"], "canonical_name": "CV formation"}
{"concept_id": "C4326237", "aliases": [], "types": ["T043"], "canonical_name": "CV assembly"}
{"concept_id": "C4326238", "aliases": [], "types": ["T042"], "canonical_name": "activation of patterning of blood vessels"}
{"concept_id": "C4326239", "aliases": [], "types": ["T042"], "canonical_name": "activation of branching involved in blood vessel morphogenesis"}
{"concept_id": "C4326240", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of patterning of blood vessels"}
{"concept_id": "C4326241", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of branching involved in blood vessel morphogenesis"}
{"concept_id": "C4326242", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein localization to endoplasmic reticulum"}
{"concept_id": "C4326243", "aliases": ["activation of protein localization in endoplasmic reticulum", "activation of protein localization in ER"], "types": ["T043"], "canonical_name": "activation of protein localisation in endoplasmic reticulum"}
{"concept_id": "C4326244", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein localization to endoplasmic reticulum"}
{"concept_id": "C4326245", "aliases": ["inhibition of protein localization in ER", "inhibition of protein localization in endoplasmic reticulum"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in endoplasmic reticulum"}
{"concept_id": "C4326250", "aliases": [], "types": ["T043"], "canonical_name": "activation of eukaryotic translation initiation factor 4F complex assembly"}
{"concept_id": "C4326251", "aliases": [], "types": ["T043"], "canonical_name": "activation of eIF4F assembly"}
{"concept_id": "C4326252", "aliases": [], "types": ["T043"], "canonical_name": "activation of eIF-4F assembly"}
{"concept_id": "C4326253", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of eukaryotic translation initiation factor 4F complex assembly"}
{"concept_id": "C4326254", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of eIF4F assembly"}
{"concept_id": "C4326255", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of eIF-4F assembly"}
{"concept_id": "C4326256", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of L-leucine import into cell"}
{"concept_id": "C4326257", "aliases": [], "types": ["T043"], "canonical_name": "activation of leucine import into cell"}
{"concept_id": "C4326258", "aliases": [], "types": ["T043"], "canonical_name": "activation of L-leucine import into cell"}
{"concept_id": "C4326259", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of L-leucine import into cell"}
{"concept_id": "C4326260", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of leucine import into cell"}
{"concept_id": "C4326261", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of L-leucine import into cell"}
{"concept_id": "C4326262", "aliases": ["downregulation of L-leucine import into cell", "down-regulation of L-leucine import into cell"], "types": ["T043"], "canonical_name": "down regulation of L-leucine import into cell"}
{"concept_id": "C4326263", "aliases": [], "types": ["T043"], "canonical_name": "regulation of L-leucine import into cell"}
{"concept_id": "C4326264", "aliases": [], "types": ["T043"], "canonical_name": "activation of Golgi lumen acidification"}
{"concept_id": "C4326265", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Golgi lumen acidification"}
{"concept_id": "C4326266", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein self-ubiquitinylation"}
{"concept_id": "C4326267", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein self-ubiquitination"}
{"concept_id": "C4326268", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein autoubiquitinylation"}
{"concept_id": "C4326269", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein autoubiquitination"}
{"concept_id": "C4326270", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein auto-ubiquitinylation"}
{"concept_id": "C4326271", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein auto-ubiquitination"}
{"concept_id": "C4326272", "aliases": [], "types": ["T043"], "canonical_name": "activation of macrophage migration"}
{"concept_id": "C4326273", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of macrophage migration"}
{"concept_id": "C4326274", "aliases": ["up regulation of pre-synaptic active zone component formation", "up-regulation of pre-synaptic active zone component assembly", "upregulation of pre-synaptic active zone component formation", "up-regulation of pre-synaptic active zone component formation", "upregulation of pre-synaptic active zone component assembly"], "types": ["T043"], "canonical_name": "up regulation of pre-synaptic active zone component assembly"}
{"concept_id": "C4326275", "aliases": ["positive regulation of pre-synaptic active zone component formation"], "types": ["T043"], "canonical_name": "positive regulation of pre-synaptic active zone component assembly"}
{"concept_id": "C4326276", "aliases": ["activation of presynaptic active zone assembly", "activation of presynaptic active zone formation", "activation of pre-synaptic active zone formation"], "types": ["T043"], "canonical_name": "activation of pre-synaptic active zone assembly"}
{"concept_id": "C4326277", "aliases": ["activation of pre-synaptic active zone component formation"], "types": ["T043"], "canonical_name": "activation of pre-synaptic active zone component assembly"}
{"concept_id": "C4326278", "aliases": ["negative regulation of pre-synaptic active zone component formation"], "types": ["T043"], "canonical_name": "negative regulation of pre-synaptic active zone component assembly"}
{"concept_id": "C4326279", "aliases": ["inhibition of presynaptic active zone formation", "inhibition of presynaptic active zone assembly", "inhibition of pre-synaptic active zone formation"], "types": ["T043"], "canonical_name": "inhibition of pre-synaptic active zone assembly"}
{"concept_id": "C4326280", "aliases": ["inhibition of pre-synaptic active zone component formation"], "types": ["T043"], "canonical_name": "inhibition of pre-synaptic active zone component assembly"}
{"concept_id": "C4326281", "aliases": ["down regulation of pre-synaptic active zone component formation", "downregulation of pre-synaptic active zone component formation", "down-regulation of pre-synaptic active zone component assembly", "downregulation of pre-synaptic active zone component assembly", "down-regulation of pre-synaptic active zone component formation"], "types": ["T043"], "canonical_name": "down regulation of pre-synaptic active zone component assembly"}
{"concept_id": "C4326282", "aliases": ["regulation of pre-synaptic active zone component formation"], "types": ["T043"], "canonical_name": "regulation of pre-synaptic active zone component assembly"}
{"concept_id": "C4326283", "aliases": [], "types": ["T040"], "canonical_name": "activation of syngamy"}
{"concept_id": "C4326284", "aliases": [], "types": ["T040"], "canonical_name": "activation of fertilization"}
{"concept_id": "C4326285", "aliases": [], "types": ["T043"], "canonical_name": "sensory cilium assembly"}
{"concept_id": "C4326286", "aliases": ["nonmotile primary cilium assembly"], "types": ["T043"], "canonical_name": "nonmotile primary cilia assembly"}
{"concept_id": "C4326287", "aliases": [], "types": ["T043"], "canonical_name": "immotile primary cilium assembly"}
{"concept_id": "C4326288", "aliases": [], "types": ["T043"], "canonical_name": "activation of synaptic facilitation"}
{"concept_id": "C4326289", "aliases": [], "types": ["T043"], "canonical_name": "activation of short-term synaptic potentiation"}
{"concept_id": "C4326290", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of synaptic facilitation"}
{"concept_id": "C4326291", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of short-term synaptic potentiation"}
{"concept_id": "C4326292", "aliases": ["upregulation of myosin II polymerization", "up-regulation of myosin II polymerization"], "types": ["T043"], "canonical_name": "up regulation of myosin II polymerization"}
{"concept_id": "C4326293", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of myosin II polymerization"}
{"concept_id": "C4326294", "aliases": [], "types": ["T043"], "canonical_name": "activation of myosin II polymerization"}
{"concept_id": "C4326295", "aliases": [], "types": ["T043"], "canonical_name": "activation of myosin II filament assembly"}
{"concept_id": "C4326296", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myosin II polymerization"}
{"concept_id": "C4326297", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myosin II polymerization"}
{"concept_id": "C4326298", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myosin II filament assembly"}
{"concept_id": "C4326299", "aliases": ["down-regulation of myosin II polymerization", "downregulation of myosin II polymerization"], "types": ["T043"], "canonical_name": "down regulation of myosin II polymerization"}
{"concept_id": "C4326300", "aliases": ["upregulation of nodal cilium formation", "up-regulation of nodal cilium formation"], "types": ["T043"], "canonical_name": "up regulation of nodal cilium formation"}
{"concept_id": "C4326301", "aliases": ["up-regulation of nodal cilium assembly", "upregulation of nodal cilium assembly"], "types": ["T043"], "canonical_name": "up regulation of nodal cilium assembly"}
{"concept_id": "C4326302", "aliases": ["upregulation of motile primary cilium formation", "upregulation of motile primary cilia formation", "up-regulation of motile primary cilia formation", "up regulation of motile primary cilium formation", "up-regulation of motile primary cilium formation"], "types": ["T043"], "canonical_name": "up regulation of motile primary cilia formation"}
{"concept_id": "C4326303", "aliases": ["up-regulation of motile primary cilium assembly", "upregulation of motile primary cilia assembly", "up regulation of motile primary cilium assembly", "up-regulation of motile primary cilia assembly", "upregulation of motile primary cilium assembly"], "types": ["T043"], "canonical_name": "up regulation of motile primary cilia assembly"}
{"concept_id": "C4326304", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of nodal cilium formation"}
{"concept_id": "C4326305", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of nodal cilium assembly"}
{"concept_id": "C4326306", "aliases": ["positive regulation of motile primary cilium formation"], "types": ["T043"], "canonical_name": "positive regulation of motile primary cilia formation"}
{"concept_id": "C4326307", "aliases": ["positive regulation of motile primary cilium assembly"], "types": ["T043"], "canonical_name": "positive regulation of motile primary cilia assembly"}
{"concept_id": "C4326308", "aliases": [], "types": ["T043"], "canonical_name": "activation of nodal cilium formation"}
{"concept_id": "C4326309", "aliases": [], "types": ["T043"], "canonical_name": "activation of nodal cilium assembly"}
{"concept_id": "C4326310", "aliases": ["activation of motile primary cilium formation"], "types": ["T043"], "canonical_name": "activation of motile primary cilia formation"}
{"concept_id": "C4326311", "aliases": ["activation of motile primary cilium assembly"], "types": ["T043"], "canonical_name": "activation of motile primary cilia assembly"}
{"concept_id": "C4326312", "aliases": ["negative regulation of nodal cilium formation"], "types": ["T043"], "canonical_name": "negative regulation of nodal cilium assembly"}
{"concept_id": "C4326313", "aliases": ["negative regulation of motile primary cilium formation"], "types": ["T043"], "canonical_name": "negative regulation of motile primary cilia formation"}
{"concept_id": "C4326314", "aliases": ["negative regulation of motile primary cilium assembly"], "types": ["T043"], "canonical_name": "negative regulation of motile primary cilia assembly"}
{"concept_id": "C4326315", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nodal cilium formation"}
{"concept_id": "C4326316", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nodal cilium assembly"}
{"concept_id": "C4326317", "aliases": ["inhibition of motile primary cilium formation"], "types": ["T043"], "canonical_name": "inhibition of motile primary cilia formation"}
{"concept_id": "C4326318", "aliases": ["inhibition of motile primary cilium assembly"], "types": ["T043"], "canonical_name": "inhibition of motile primary cilia assembly"}
{"concept_id": "C4326319", "aliases": ["downregulation of nodal cilium formation", "down-regulation of nodal cilium formation"], "types": ["T043"], "canonical_name": "down regulation of nodal cilium formation"}
{"concept_id": "C4326320", "aliases": ["downregulation of nodal cilium assembly", "down-regulation of nodal cilium assembly"], "types": ["T043"], "canonical_name": "down regulation of nodal cilium assembly"}
{"concept_id": "C4326321", "aliases": ["downregulation of motile primary cilium formation", "downregulation of motile primary cilia formation", "down regulation of motile primary cilium formation", "down-regulation of motile primary cilium formation", "down-regulation of motile primary cilia formation"], "types": ["T043"], "canonical_name": "down regulation of motile primary cilia formation"}
{"concept_id": "C4326322", "aliases": ["regulation of nodal cilium formation"], "types": ["T043"], "canonical_name": "regulation of nodal cilium assembly"}
{"concept_id": "C4326323", "aliases": ["regulation of motile primary cilium formation"], "types": ["T038"], "canonical_name": "regulation of motile primary cilia formation"}
{"concept_id": "C4326324", "aliases": ["regulation of motile primary cilium assembly"], "types": ["T038"], "canonical_name": "regulation of motile primary cilia assembly"}
{"concept_id": "C4326325", "aliases": [], "types": ["T043"], "canonical_name": "trichome papilla assembly"}
{"concept_id": "C4326326", "aliases": [], "types": ["T045"], "canonical_name": "activation of triplex DNA binding"}
{"concept_id": "C4326327", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of triplex DNA binding"}
{"concept_id": "C4326328", "aliases": [], "types": ["T045"], "canonical_name": "activation of tetraplex DNA binding"}
{"concept_id": "C4326329", "aliases": [], "types": ["T045"], "canonical_name": "activation of quadruplex DNA binding"}
{"concept_id": "C4326330", "aliases": ["activation of G-quartet DNA binding"], "types": ["T045"], "canonical_name": "activation of G quartet DNA binding"}
{"concept_id": "C4326331", "aliases": ["activation of G-quadruplex DNA binding"], "types": ["T045"], "canonical_name": "activation of G quadruplex DNA binding"}
{"concept_id": "C4326332", "aliases": [], "types": ["T045"], "canonical_name": "activation of G-DNA binding"}
{"concept_id": "C4326333", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of tetraplex DNA binding"}
{"concept_id": "C4326334", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of quadruplex DNA binding"}
{"concept_id": "C4326335", "aliases": ["inhibition of G quartet DNA binding", "inhibition of G-quadruplex DNA binding", "inhibition of G-DNA binding", "inhibition of G-quartet DNA binding"], "types": ["T045"], "canonical_name": "inhibition of G quadruplex DNA binding"}
{"concept_id": "C4326336", "aliases": ["regulation of G-DNA binding", "regulation of quadruplex DNA binding", "regulation of G quartet DNA binding", "regulation of tetraplex DNA binding", "regulation of G quartet binding", "regulation of G quadruplex DNA binding", "regulation of G-quartet DNA binding", "regulation of G-quartet binding"], "types": ["T045"], "canonical_name": "regulation of G-quadruplex DNA binding", "definition": "Any process that modulates the frequency, rate or extent of G-quadruplex DNA binding. [GO_REF:0000059, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4326337", "aliases": [], "types": ["T042"], "canonical_name": "activation of branching morphogenesis of a nerve"}
{"concept_id": "C4326338", "aliases": [], "types": ["T043"], "canonical_name": "activation of sensory neuron axon guidance"}
{"concept_id": "C4326339", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sensory neuron axon guidance"}
{"concept_id": "C4326340", "aliases": [], "types": ["T043"], "canonical_name": "activation of anterior/posterior axon pathfinding"}
{"concept_id": "C4326341", "aliases": ["activation of anterior/posterior axon guidance"], "types": ["T043"], "canonical_name": "activation of anterior-posterior axon guidance"}
{"concept_id": "C4326342", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of anterior/posterior axon pathfinding"}
{"concept_id": "C4326343", "aliases": ["inhibition of anterior/posterior axon guidance"], "types": ["T043"], "canonical_name": "inhibition of anterior-posterior axon guidance"}
{"concept_id": "C4326344", "aliases": [], "types": ["T043"], "canonical_name": "activation of motor neuron migration"}
{"concept_id": "C4326345", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of motor neuron migration"}
{"concept_id": "C4326346", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-glutamine synthetase activity"}
{"concept_id": "C4326347", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-glutamate:ammonia ligase (ADP-forming)"}
{"concept_id": "C4326348", "aliases": [], "types": ["T044"], "canonical_name": "activation of glutamylhydroxamic synthetase activity"}
{"concept_id": "C4326349", "aliases": [], "types": ["T044"], "canonical_name": "activation of glutamine synthetase activity"}
{"concept_id": "C4326350", "aliases": [], "types": ["T044"], "canonical_name": "activation of glutamate-ammonia ligase activity"}
{"concept_id": "C4326351", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-glutamine synthetase activity"}
{"concept_id": "C4326352", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-glutamate:ammonia ligase (ADP-forming)"}
{"concept_id": "C4326353", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glutamylhydroxamic synthetase activity"}
{"concept_id": "C4326354", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glutamine synthetase activity"}
{"concept_id": "C4326355", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of glutamate-ammonia ligase activity"}
{"concept_id": "C4326356", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein localization to membrane"}
{"concept_id": "C4326357", "aliases": ["activation of protein localization in membrane"], "types": ["T043"], "canonical_name": "activation of protein localisation in membrane"}
{"concept_id": "C4326358", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein localization to membrane"}
{"concept_id": "C4326359", "aliases": ["inhibition of protein localization in membrane"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in membrane"}
{"concept_id": "C4326360", "aliases": [], "types": ["T043"], "canonical_name": "frizzled-1 receptor signaling pathway involved in stem cell proliferation"}
{"concept_id": "C4326361", "aliases": [], "types": ["T044"], "canonical_name": "activation of histone lysine H3 K79 dimethylation"}
{"concept_id": "C4326362", "aliases": ["activation of histone H3-K79 dimethylation"], "types": ["T044"], "canonical_name": "activation of histone H3 K79 dimethylation"}
{"concept_id": "C4326363", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone lysine H3 K79 dimethylation"}
{"concept_id": "C4326364", "aliases": ["inhibition of histone H3-K79 dimethylation"], "types": ["T044"], "canonical_name": "inhibition of histone H3 K79 dimethylation"}
{"concept_id": "C4326365", "aliases": [], "types": ["T043"], "canonical_name": "activation of coated pit formation"}
{"concept_id": "C4326366", "aliases": [], "types": ["T043"], "canonical_name": "activation of coated pit assembly"}
{"concept_id": "C4326367", "aliases": [], "types": ["T043"], "canonical_name": "activation of clathrin-coated pit formation"}
{"concept_id": "C4326368", "aliases": [], "types": ["T043"], "canonical_name": "activation of clathrin-coated pit assembly"}
{"concept_id": "C4326369", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of coated pit formation"}
{"concept_id": "C4326370", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of coated pit assembly"}
{"concept_id": "C4326371", "aliases": ["inhibition of clathrin-coated pit formation"], "types": ["T043"], "canonical_name": "inhibition of clathrin-coated pit assembly"}
{"concept_id": "C4326372", "aliases": [], "types": ["T045"], "canonical_name": "activation of G-quadruplex DNA unwinding"}
{"concept_id": "C4326373", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of G-quadruplex DNA unwinding"}
{"concept_id": "C4326374", "aliases": [], "types": ["T045"], "canonical_name": "activation of duplex DNA melting"}
{"concept_id": "C4326375", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA unwinding"}
{"concept_id": "C4326376", "aliases": [], "types": ["T045"], "canonical_name": "activation of DNA duplex unwinding"}
{"concept_id": "C4326377", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of duplex DNA melting"}
{"concept_id": "C4326378", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA unwinding"}
{"concept_id": "C4326379", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of DNA duplex unwinding"}
{"concept_id": "C4326380", "aliases": ["up-regulation of VSMC apoptosis", "upregulation of VSMC apoptosis"], "types": ["T043"], "canonical_name": "up regulation of VSMC apoptosis"}
{"concept_id": "C4326381", "aliases": ["upregulation of vascular smooth muscle cell apoptosis", "up-regulation of vascular smooth muscle cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of vascular smooth muscle cell apoptosis"}
{"concept_id": "C4326382", "aliases": ["upregulation of vascular associated smooth muscle cell apoptosis", "up-regulation of vascular associated smooth muscle cell apoptosis"], "types": ["T043"], "canonical_name": "up regulation of vascular associated smooth muscle cell apoptosis"}
{"concept_id": "C4326383", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of VSMC apoptosis"}
{"concept_id": "C4326384", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of vascular smooth muscle cell apoptosis"}
{"concept_id": "C4326385", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of vascular associated smooth muscle cell apoptosis"}
{"concept_id": "C4326386", "aliases": [], "types": ["T043"], "canonical_name": "activation of VSMC apoptotic process"}
{"concept_id": "C4326387", "aliases": [], "types": ["T043"], "canonical_name": "activation of VSMC apoptosis"}
{"concept_id": "C4326388", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular smooth muscle cell apoptotic process"}
{"concept_id": "C4326389", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular smooth muscle cell apoptosis"}
{"concept_id": "C4326390", "aliases": ["activation of vascular associated smooth muscle cell apoptotic process"], "types": ["T043"], "canonical_name": "activation of vascular associated smooth muscle cell apoptosis"}
{"concept_id": "C4326391", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of VSMC apoptosis"}
{"concept_id": "C4326392", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of vascular smooth muscle cell apoptosis"}
{"concept_id": "C4326393", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of vascular associated smooth muscle cell apoptosis"}
{"concept_id": "C4326394", "aliases": ["inhibition of vascular associated smooth muscle cell apoptotic process"], "types": ["T043"], "canonical_name": "inhibition of VSMC apoptotic process"}
{"concept_id": "C4326395", "aliases": ["inhibition of vascular associated smooth muscle cell apoptosis"], "types": ["T043"], "canonical_name": "inhibition of VSMC apoptosis"}
{"concept_id": "C4326396", "aliases": ["inhibition of vascular smooth muscle cell apoptotic process"], "types": ["T043"], "canonical_name": "inhibition of vascular smooth muscle cell apoptosis"}
{"concept_id": "C4326397", "aliases": ["downregulation of VSMC apoptosis", "downregulation of vascular associated smooth muscle cell apoptosis", "down-regulation of vascular associated smooth muscle cell apoptosis", "down regulation of vascular associated smooth muscle cell apoptosis", "down-regulation of VSMC apoptosis"], "types": ["T043"], "canonical_name": "down regulation of VSMC apoptosis"}
{"concept_id": "C4326398", "aliases": ["down-regulation of vascular smooth muscle cell apoptosis", "downregulation of vascular smooth muscle cell apoptosis"], "types": ["T043"], "canonical_name": "down regulation of vascular smooth muscle cell apoptosis"}
{"concept_id": "C4326399", "aliases": [], "types": ["T043"], "canonical_name": "regulation of VSMC apoptosis"}
{"concept_id": "C4326400", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vascular smooth muscle cell apoptosis"}
{"concept_id": "C4326401", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vascular associated smooth muscle cell apoptosis"}
{"concept_id": "C4326402", "aliases": [], "types": ["T043"], "canonical_name": "activation of lymphoid progenitor cell differentiation"}
{"concept_id": "C4326403", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of lymphoid progenitor cell differentiation"}
{"concept_id": "C4326404", "aliases": [], "types": ["T043"], "canonical_name": "activation of myeloid progenitor cell differentiation"}
{"concept_id": "C4326405", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of myeloid progenitor cell differentiation"}
{"concept_id": "C4326406", "aliases": [], "types": ["T043"], "canonical_name": "activation of IgG-mediated phagocytosis"}
{"concept_id": "C4326407", "aliases": [], "types": ["T043"], "canonical_name": "activation of Fcgamma receptor-mediated phagocytosis"}
{"concept_id": "C4326408", "aliases": ["activation of Fc-gamma receptor signalling pathway involved in phagocytosis"], "types": ["T043"], "canonical_name": "activation of Fc-gamma receptor signaling pathway involved in phagocytosis"}
{"concept_id": "C4326409", "aliases": [], "types": ["T043"], "canonical_name": "activation of Fc gamma receptor-dependent phagocytosis"}
{"concept_id": "C4326410", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of IgG-mediated phagocytosis"}
{"concept_id": "C4326411", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Fcgamma receptor-mediated phagocytosis"}
{"concept_id": "C4326412", "aliases": ["inhibition of Fc-gamma receptor signalling pathway involved in phagocytosis"], "types": ["T043"], "canonical_name": "inhibition of Fc-gamma receptor signaling pathway involved in phagocytosis"}
{"concept_id": "C4326413", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Fc gamma receptor-dependent phagocytosis"}
{"concept_id": "C4326414", "aliases": [], "types": ["T043"], "canonical_name": "activation of mitochondrial ATP synthesis coupled electron transport"}
{"concept_id": "C4326415", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitochondrial ATP synthesis coupled electron transport"}
{"concept_id": "C4326416", "aliases": [], "types": ["T043"], "canonical_name": "regulation of organelle ATP synthesis coupled electron transport"}
{"concept_id": "C4326417", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial electron transport"}
{"concept_id": "C4326418", "aliases": [], "types": ["T043"], "canonical_name": "activation of clathrin coat assembly"}
{"concept_id": "C4326419", "aliases": [], "types": ["T043"], "canonical_name": "activation of clathrin cage assembly"}
{"concept_id": "C4326420", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of clathrin coat assembly"}
{"concept_id": "C4326421", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of clathrin cage assembly"}
{"concept_id": "C4326422", "aliases": [], "types": ["T044"], "canonical_name": "activation of histone H3-K4 trimethylation"}
{"concept_id": "C4326423", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histone H3-K4 trimethylation"}
{"concept_id": "C4326424", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling"}
{"concept_id": "C4326425", "aliases": [], "types": ["T043"], "canonical_name": "activation of retrograde trans-synaptic signaling by neuropeptide"}
{"concept_id": "C4326426", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling"}
{"concept_id": "C4326427", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of retrograde trans-synaptic signaling by neuropeptide"}
{"concept_id": "C4326428", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neuropeptide-mediated retrograde trans-synaptic signaling"}
{"concept_id": "C4326429", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neuropeptide-mediated retrograde trans-synaptic signaling"}
{"concept_id": "C4326430", "aliases": ["signal transmission via intracellular cascade involved in up-regulation of cell growth", "signal transmission via intracellular cascade involved in upregulation of cell growth"], "types": ["T043"], "canonical_name": "signal transmission via intracellular cascade involved in up regulation of cell growth"}
{"concept_id": "C4326431", "aliases": [], "types": ["T043"], "canonical_name": "signal transmission via intracellular cascade involved in stimulation of cell growth"}
{"concept_id": "C4326432", "aliases": [], "types": ["T043"], "canonical_name": "signal transmission via intracellular cascade involved in positive regulation of cell growth"}
{"concept_id": "C4326433", "aliases": [], "types": ["T043"], "canonical_name": "signal transmission via intracellular cascade involved in activation of cell growth"}
{"concept_id": "C4326434", "aliases": ["signal transduction via intracellular signaling cascade involved in upregulation of cell growth", "signal transduction via intracellular signaling cascade involved in up-regulation of cell growth"], "types": ["T043"], "canonical_name": "signal transduction via intracellular signaling cascade involved in up regulation of cell growth"}
{"concept_id": "C4326435", "aliases": [], "types": ["T044"], "canonical_name": "signal transduction via intracellular signaling cascade involved in stimulation of cell growth"}
{"concept_id": "C4326436", "aliases": [], "types": ["T044"], "canonical_name": "signal transduction via intracellular signaling cascade involved in positive regulation of cell growth"}
{"concept_id": "C4326437", "aliases": [], "types": ["T044"], "canonical_name": "signal transduction via intracellular signaling cascade involved in activation of cell growth"}
{"concept_id": "C4326438", "aliases": ["protein kinase cascade involved in upregulation of cell growth", "protein kinase cascade involved in up-regulation of cell growth"], "types": ["T044"], "canonical_name": "protein kinase cascade involved in up regulation of cell growth"}
{"concept_id": "C4326439", "aliases": [], "types": ["T044"], "canonical_name": "protein kinase cascade involved in stimulation of cell growth"}
{"concept_id": "C4326440", "aliases": [], "types": ["T044"], "canonical_name": "protein kinase cascade involved in positive regulation of cell growth"}
{"concept_id": "C4326441", "aliases": [], "types": ["T044"], "canonical_name": "protein kinase cascade involved in activation of cell growth"}
{"concept_id": "C4326442", "aliases": ["intracellular signaling pathway involved in up-regulation of cell growth", "intracellular signaling pathway involved in upregulation of cell growth"], "types": ["T044"], "canonical_name": "intracellular signaling pathway involved in up regulation of cell growth"}
{"concept_id": "C4326443", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signaling pathway involved in stimulation of cell growth"}
{"concept_id": "C4326444", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signaling pathway involved in positive regulation of cell growth"}
{"concept_id": "C4326445", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signaling pathway involved in activation of cell growth"}
{"concept_id": "C4326446", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signaling chain involved in stimulation of cell growth"}
{"concept_id": "C4326447", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signaling chain involved in activation of cell growth"}
{"concept_id": "C4326448", "aliases": ["intracellular signaling cascade involved in upregulation of cell growth", "intracellular signaling cascade involved in up-regulation of cell growth"], "types": ["T044"], "canonical_name": "intracellular signaling cascade involved in up regulation of cell growth"}
{"concept_id": "C4326449", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signaling cascade involved in stimulation of cell growth"}
{"concept_id": "C4326450", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signaling cascade involved in positive regulation of cell growth"}
{"concept_id": "C4326451", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signaling cascade involved in activation of cell growth"}
{"concept_id": "C4326452", "aliases": ["intracellular signal transduction pathway involved in up-regulation of cell growth", "intracellular signal transduction pathway involved in upregulation of cell growth"], "types": ["T044"], "canonical_name": "intracellular signal transduction pathway involved in up regulation of cell growth"}
{"concept_id": "C4326453", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signal transduction pathway involved in stimulation of cell growth"}
{"concept_id": "C4326454", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signal transduction pathway involved in positive regulation of cell growth"}
{"concept_id": "C4326455", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signal transduction pathway involved in activation of cell growth"}
{"concept_id": "C4326456", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signal transduction involved in stimulation of cell growth"}
{"concept_id": "C4326457", "aliases": [], "types": ["T044"], "canonical_name": "intracellular signal transduction involved in activation of cell growth"}
{"concept_id": "C4326458", "aliases": ["intracellular protein kinase cascade involved in upregulation of cell growth", "intracellular protein kinase cascade involved in up-regulation of cell growth"], "types": ["T044"], "canonical_name": "intracellular protein kinase cascade involved in up regulation of cell growth"}
{"concept_id": "C4326459", "aliases": [], "types": ["T044"], "canonical_name": "intracellular protein kinase cascade involved in stimulation of cell growth"}
{"concept_id": "C4326460", "aliases": [], "types": ["T044"], "canonical_name": "intracellular protein kinase cascade involved in positive regulation of cell growth"}
{"concept_id": "C4326461", "aliases": [], "types": ["T044"], "canonical_name": "intracellular protein kinase cascade involved in activation of cell growth"}
{"concept_id": "C4326462", "aliases": ["upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326463", "aliases": ["up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326464", "aliases": ["up-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis", "upregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "up regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326465", "aliases": ["upregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation", "up-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "up regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326466", "aliases": ["up-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "up regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326467", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326468", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326469", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326470", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326471", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326472", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of midbrain dopaminergic neuron differentiation by positive regulation of Wnt signaling"}
{"concept_id": "C4326473", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-mediated midbrain DA neuron differentiation"}
{"concept_id": "C4326474", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326475", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326476", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326477", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-activated signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326478", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326479", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326480", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326481", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326482", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326483", "aliases": [], "types": ["T043"], "canonical_name": "activation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326484", "aliases": ["activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326485", "aliases": ["activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326486", "aliases": ["activation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "activation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326487", "aliases": ["activation of Wnt receptor signalling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "activation of Wnt receptor signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326488", "aliases": ["activation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "activation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326489", "aliases": ["activation of Wingless signalling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "activation of Wingless signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326490", "aliases": ["activation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "activation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326491", "aliases": ["activation of Wingless signalling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "activation of Wingless signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326492", "aliases": ["activation of Wingless signalling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "activation of Wingless signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326493", "aliases": ["activation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "activation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326494", "aliases": ["activation of Wg signalling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "activation of Wg signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326495", "aliases": ["activation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "activation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326496", "aliases": ["activation of Wg signalling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "activation of Wg signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326497", "aliases": ["activation of Wg signalling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "activation of Wg signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326498", "aliases": ["activation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "activation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326499", "aliases": ["activation of frizzled signalling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "activation of frizzled signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326500", "aliases": ["activation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "activation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326501", "aliases": ["activation of frizzled signalling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "activation of frizzled signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326502", "aliases": ["activation of frizzled signalling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "activation of frizzled signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326503", "aliases": ["activation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "activation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326504", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326505", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326506", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326507", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326508", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326509", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of midbrain dopaminergic neuron differentiation by negative regulation of Wnt signaling"}
{"concept_id": "C4326510", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-mediated midbrain DA neuron differentiation"}
{"concept_id": "C4326511", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326512", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326513", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-activated signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326514", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-activated signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326515", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326516", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326517", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326518", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326519", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326520", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326521", "aliases": ["inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326522", "aliases": ["inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326523", "aliases": ["inhibition of Wnt receptor signalling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "inhibition of Wnt receptor signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326524", "aliases": ["inhibition of Wnt receptor signalling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "inhibition of Wnt receptor signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326525", "aliases": ["inhibition of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "inhibition of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326526", "aliases": ["inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326527", "aliases": ["inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326528", "aliases": ["inhibition of Wingless signalling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "inhibition of Wingless signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326529", "aliases": ["inhibition of Wingless signalling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "inhibition of Wingless signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326530", "aliases": ["inhibition of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "inhibition of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326531", "aliases": ["inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326532", "aliases": ["inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326533", "aliases": ["inhibition of Wg signalling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "inhibition of Wg signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326534", "aliases": ["inhibition of Wg signalling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "inhibition of Wg signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326535", "aliases": ["inhibition of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "inhibition of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326536", "aliases": ["inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326537", "aliases": ["inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326538", "aliases": ["inhibition of frizzled signalling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "inhibition of frizzled signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326539", "aliases": ["inhibition of frizzled signalling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "inhibition of frizzled signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326540", "aliases": ["inhibition of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "inhibition of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326541", "aliases": ["down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production", "downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"], "types": ["T043"], "canonical_name": "down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326542", "aliases": ["down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"], "types": ["T043"], "canonical_name": "down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326543", "aliases": ["down-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis", "downregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis"], "types": ["T043"], "canonical_name": "down regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326544", "aliases": ["down-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation", "downregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "down regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326545", "aliases": ["downregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "down regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326546", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production"}
{"concept_id": "C4326547", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation"}
{"concept_id": "C4326548", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis"}
{"concept_id": "C4326549", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation"}
{"concept_id": "C4326550", "aliases": [], "types": ["T044"], "canonical_name": "regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate"}
{"concept_id": "C4326551", "aliases": [], "types": ["T044"], "canonical_name": "regulation of midbrain dopaminergic neuron differentiation by regulation of Wnt signaling"}
{"concept_id": "C4326552", "aliases": [], "types": ["T042"], "canonical_name": "activation of plant organ morphogenesis"}
{"concept_id": "C4326553", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of plant organ morphogenesis"}
{"concept_id": "C4326554", "aliases": [], "types": ["T043"], "canonical_name": "VSMC differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4326555", "aliases": ["vascular smooth muscle cell differentiation involved in phenotypic dimorphism"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism"}
{"concept_id": "C4326556", "aliases": ["activation of amoeboid sperm movement", "activation of amoeboid sperm motility", "activation of ameboid sperm movement"], "types": ["T043"], "canonical_name": "activation of ameboid sperm motility"}
{"concept_id": "C4326557", "aliases": ["inhibition of amoeboid sperm movement", "inhibition of ameboid sperm movement", "inhibition of amoeboid sperm motility"], "types": ["T043"], "canonical_name": "inhibition of ameboid sperm motility"}
{"concept_id": "C4326558", "aliases": [], "types": ["T043"], "canonical_name": "activation of dense core vesicle exocytosis"}
{"concept_id": "C4326559", "aliases": [], "types": ["T043"], "canonical_name": "activation of dense core granule exocytosis"}
{"concept_id": "C4326560", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dense core vesicle exocytosis"}
{"concept_id": "C4326561", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of dense core granule exocytosis"}
{"concept_id": "C4326562", "aliases": [], "types": ["T044"], "canonical_name": "activation of creatine transmembrane transporter activity"}
{"concept_id": "C4326563", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of creatine transmembrane transporter activity"}
{"concept_id": "C4326564", "aliases": ["up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "up regulation of activated CD8-positive, alpha-beta T cell apoptosis", "up regulation of activated CD8-positive, alpha-beta T-cell apoptotic process", "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "up-regulation of activated CD8-positive, alpha-beta T-cell apoptosis", "upregulation of activated CD8-positive, alpha-beta T-cell apoptosis", "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "positive regulation of activated CD8-positive, alpha-beta T-cell apoptosis", "up-regulation of activated CD8-positive, alpha-beta T cell apoptotic process", "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "up-regulation of activated CD8-positive, alpha-beta T cell apoptosis", "upregulation of activated CD8-positive, alpha-beta T-cell apoptotic process", "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "up regulation of activated CD8-positive, alpha-beta T-cell apoptosis", "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "positive regulation of activated CD8-positive, alpha-beta T cell apoptosis", "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "up regulation of activated CD8-positive, alpha-beta T cell apoptotic process", "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "upregulation of activated CD8-positive, alpha-beta T cell apoptotic process", "up-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process", "positive regulation of activated CD8-positive, alpha-beta T-cell apoptotic process", "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "upregulation of activated CD8-positive, alpha-beta T cell apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C4326565", "aliases": ["activation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "activation of activated CD8-positive, alpha-beta T cell apoptotic process", "activation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "activation of activated CD8-positive, alpha-beta T-cell apoptosis", "activation of activated CD8-positive, alpha-beta T-cell apoptotic process", "activation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "activation of activated CD8-positive, alpha-beta T lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "activation of activated CD8-positive, alpha-beta T cell apoptosis"}
{"concept_id": "C4326566", "aliases": ["negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "negative regulation of activated CD8-positive, alpha-beta T-cell apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of activated CD8-positive, alpha-beta T cell apoptosis"}
{"concept_id": "C4326567", "aliases": ["inhibition of activated CD8-positive, alpha-beta T-cell apoptotic process", "inhibition of activated CD8-positive, alpha-beta T-cell apoptosis", "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "inhibition of activated CD8-positive, alpha-beta T cell apoptotic process"], "types": ["T043"], "canonical_name": "inhibition of activated CD8-positive, alpha-beta T cell apoptosis"}
{"concept_id": "C4326568", "aliases": ["downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "down-regulation of activated CD8-positive, alpha-beta T cell apoptosis", "down regulation of activated CD8-positive, alpha-beta T cell apoptosis", "down-regulation of activated CD8-positive, alpha-beta T cell apoptotic process", "downregulation of activated CD8-positive, alpha-beta T-cell apoptotic process", "negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "downregulation of activated CD8-positive, alpha-beta T cell apoptosis", "down-regulation of activated CD8-positive, alpha-beta T-cell apoptosis", "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "downregulation of activated CD8-positive, alpha-beta T-cell apoptosis", "downregulation of activated CD8-positive, alpha-beta T cell apoptotic process", "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "down regulation of activated CD8-positive, alpha-beta T-cell apoptotic process", "down regulation of activated CD8-positive, alpha-beta T cell apoptotic process", "down-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process", "down regulation of activated CD8-positive, alpha-beta T-cell apoptosis", "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "negative regulation of activated CD8-positive, alpha-beta T-cell apoptotic process", "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C4326569", "aliases": ["regulation of activated CD8-positive, alpha-beta T-cell apoptosis", "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis", "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "regulation of activated CD8-positive, alpha-beta T cell apoptosis", "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process", "regulation of activated CD8-positive, alpha-beta T-cell apoptotic process"], "types": ["T043"], "canonical_name": "regulation of activated CD8-positive, alpha-beta T cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C4326570", "aliases": ["up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis", "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "upregulation of activated CD4-positive, alpha-beta T cell apoptosis", "up regulation of activated CD4-positive, alpha-beta T-cell apoptosis", "up-regulation of activated CD4-positive, alpha-beta T cell apoptosis", "up regulation of activated CD4-positive, alpha-beta T cell apoptosis", "upregulation of activated CD4-positive, alpha-beta T-cell apoptosis", "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis", "up-regulation of activated CD4-positive, alpha-beta T-cell apoptosis", "positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis", "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis", "positive regulation of activated CD4-positive, alpha-beta T-cell apoptosis", "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of activated CD4-positive, alpha-beta T cell apoptosis"}
{"concept_id": "C4326571", "aliases": ["activation of activated CD4-positive, alpha-beta T-cell apoptosis", "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "activation of activated CD4-positive, alpha-beta T cell apoptotic process", "activation of activated CD4-positive, alpha-beta T-cell apoptotic process", "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "activation of activated CD4-positive, alpha-beta T lymphocyte apoptosis", "activation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process"], "types": ["T043"], "canonical_name": "activation of activated CD4-positive, alpha-beta T cell apoptosis"}
{"concept_id": "C4326572", "aliases": ["negative regulation of activated CD4-positive, alpha-beta T-cell apoptosis", "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis", "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of activated CD4-positive, alpha-beta T cell apoptosis"}
{"concept_id": "C4326573", "aliases": ["inhibition of activated CD4-positive, alpha-beta T-cell apoptotic process", "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptosis", "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "inhibition of activated CD4-positive, alpha-beta T-cell apoptosis", "inhibition of activated CD4-positive, alpha-beta T cell apoptotic process", "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptotic process"], "types": ["T043"], "canonical_name": "inhibition of activated CD4-positive, alpha-beta T cell apoptosis"}
{"concept_id": "C4326574", "aliases": ["downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "down-regulation of activated CD4-positive, alpha-beta T cell apoptosis", "downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "negative regulation of activated CD4-positive, alpha-beta T-cell apoptotic process", "down regulation of activated CD4-positive, alpha-beta T-cell apoptotic process", "downregulation of activated CD4-positive, alpha-beta T-cell apoptotic process", "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis", "down-regulation of activated CD4-positive, alpha-beta T cell apoptotic process", "down-regulation of activated CD4-positive, alpha-beta T-cell apoptosis", "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "downregulation of activated CD4-positive, alpha-beta T cell apoptotic process", "down regulation of activated CD4-positive, alpha-beta T-cell apoptosis", "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "down regulation of activated CD4-positive, alpha-beta T cell apoptosis", "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "downregulation of activated CD4-positive, alpha-beta T-cell apoptosis", "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "down-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process", "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "down regulation of activated CD4-positive, alpha-beta T cell apoptotic process", "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis", "downregulation of activated CD4-positive, alpha-beta T cell apoptosis", "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "negative regulation of activated CD4-positive, alpha-beta T cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C4326575", "aliases": ["regulation of activated CD4-positive, alpha-beta T-cell apoptotic process", "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "regulation of activated CD4-positive, alpha-beta T cell apoptosis", "regulation of activated CD4-positive, alpha-beta T-cell apoptosis", "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis"], "types": ["T043"], "canonical_name": "regulation of activated CD4-positive, alpha-beta T cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C4326576", "aliases": ["activated CD4-positive, alpha-beta T cell apoptosis", "activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "activated CD4-positive, alpha-beta T-lymphocyte apoptosis", "activated CD4-positive, alpha-beta T-cell apoptosis", "activated CD4-positive, alpha-beta T lymphocyte apoptosis", "activated CD4-positive, alpha-beta T-cell apoptotic process", "activated CD4-positive, alpha-beta T-lymphocyte apoptotic process"], "types": ["T043"], "canonical_name": "activated CD4-positive, alpha-beta T cell apoptotic process", "definition": "Any apoptotic process in an activated CD4-positive, alpha-beta T cell. [GO_REF:0000085, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C4326577", "aliases": ["activated CD8-positive, alpha-beta T cell apoptosis", "activated CD8-positive, alpha-beta T-lymphocyte apoptosis", "activated CD8-positive, alpha-beta T-cell apoptosis", "activated CD8-positive, alpha-beta T lymphocyte apoptosis", "activated CD8-positive, alpha-beta T-cell apoptotic process", "activated CD8-positive, alpha-beta T lymphocyte apoptotic process", "activated CD8-positive, alpha-beta T-lymphocyte apoptotic process"], "types": ["T043"], "canonical_name": "activated CD8-positive, alpha-beta T cell apoptotic process", "definition": "Any apoptotic process in an activated CD8-positive, alpha-beta T cell. [GO_REF:0000085, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C4326578", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein localisation to cell division site involved in cytokinetic cell separation"}
{"concept_id": "C4326579", "aliases": [], "types": ["T043"], "canonical_name": "activation of recruitment of presynaptic proteins"}
{"concept_id": "C4326580", "aliases": ["activation of protein localization to presynapse"], "types": ["T043"], "canonical_name": "activation of protein localisation to presynapse"}
{"concept_id": "C4326581", "aliases": ["activation of protein localization in presynapse"], "types": ["T043"], "canonical_name": "activation of protein localisation in presynapse"}
{"concept_id": "C4326582", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of recruitment of presynaptic proteins"}
{"concept_id": "C4326583", "aliases": ["inhibition of protein localization to presynapse"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to presynapse"}
{"concept_id": "C4326584", "aliases": ["inhibition of protein localization in presynapse"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in presynapse"}
{"concept_id": "C4326585", "aliases": [], "types": ["T045"], "canonical_name": "activation of snRNA transcription from RNA polymerase II promoter"}
{"concept_id": "C4326586", "aliases": [], "types": ["T045"], "canonical_name": "activation of snRNA transcription from Pol II promoter"}
{"concept_id": "C4326587", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of snRNA transcription from RNA polymerase II promoter"}
{"concept_id": "C4326588", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of snRNA transcription from Pol II promoter"}
{"concept_id": "C4326589", "aliases": ["HEX S complex location"], "types": ["T026"], "canonical_name": "HEX S complex"}
{"concept_id": "C4326590", "aliases": ["HEX B complex location"], "types": ["T026"], "canonical_name": "HEX B complex"}
{"concept_id": "C4326591", "aliases": ["HEX A complex location"], "types": ["T026"], "canonical_name": "HEX A complex"}
{"concept_id": "C4326592", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of warburg's respiratory enzyme activity"}
{"concept_id": "C4326593", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of indophenolase"}
{"concept_id": "C4326594", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of indophenol oxidase"}
{"concept_id": "C4326595", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ferrocytochrome-c:oxygen oxidoreductase"}
{"concept_id": "C4326596", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ferrocytochrome c oxidase"}
{"concept_id": "C4326597", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cytochrome oxidase activity"}
{"concept_id": "C4326598", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cytochrome aa3 activity"}
{"concept_id": "C4326599", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cytochrome a3 activity"}
{"concept_id": "C4326600", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of complex IV (mitochondrial electron transport) activity"}
{"concept_id": "C4326601", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cbb3-type cytochrome c oxidase"}
{"concept_id": "C4326602", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of caa3-type cytochrome c oxidase"}
{"concept_id": "C4326603", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ba3-type cytochrome c oxidase"}
{"concept_id": "C4326604", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of aa3-type cytochrome c oxidase"}
{"concept_id": "C4326605", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of warburg's respiratory enzyme activity"}
{"concept_id": "C4326606", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of NADH cytochrome c oxidase"}
{"concept_id": "C4326607", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of indophenolase"}
{"concept_id": "C4326608", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of indophenol oxidase"}
{"concept_id": "C4326609", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ferrocytochrome-c:oxygen oxidoreductase"}
{"concept_id": "C4326610", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ferrocytochrome c oxidase"}
{"concept_id": "C4326611", "aliases": ["inhibition of cytochrome-c oxidase activity"], "types": ["T044"], "canonical_name": "inhibition of cytochrome c oxidase activity"}
{"concept_id": "C4326612", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytochrome oxidase activity"}
{"concept_id": "C4326613", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytochrome aa3 activity"}
{"concept_id": "C4326614", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cytochrome a3 activity"}
{"concept_id": "C4326615", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of complex IV (mitochondrial electron transport) activity"}
{"concept_id": "C4326616", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cbb3-type cytochrome c oxidase"}
{"concept_id": "C4326617", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of caa3-type cytochrome c oxidase"}
{"concept_id": "C4326618", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ba3-type cytochrome c oxidase"}
{"concept_id": "C4326619", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aa3-type cytochrome c oxidase"}
{"concept_id": "C4326620", "aliases": ["down-regulation of warburg's respiratory enzyme activity", "downregulation of warburg's respiratory enzyme activity"], "types": ["T044"], "canonical_name": "down regulation of warburg's respiratory enzyme activity"}
{"concept_id": "C4326621", "aliases": ["downregulation of indophenolase", "down-regulation of indophenolase"], "types": ["T044"], "canonical_name": "down regulation of indophenolase"}
{"concept_id": "C4326622", "aliases": ["downregulation of indophenol oxidase", "down-regulation of indophenol oxidase"], "types": ["T044"], "canonical_name": "down regulation of indophenol oxidase"}
{"concept_id": "C4326623", "aliases": ["downregulation of ferrocytochrome-c:oxygen oxidoreductase", "down-regulation of ferrocytochrome-c:oxygen oxidoreductase"], "types": ["T044"], "canonical_name": "down regulation of ferrocytochrome-c:oxygen oxidoreductase"}
{"concept_id": "C4326624", "aliases": ["down-regulation of ferrocytochrome c oxidase", "downregulation of ferrocytochrome c oxidase"], "types": ["T044"], "canonical_name": "down regulation of ferrocytochrome c oxidase"}
{"concept_id": "C4326625", "aliases": ["downregulation of cytochrome oxidase activity", "down-regulation of cytochrome oxidase activity"], "types": ["T044"], "canonical_name": "down regulation of cytochrome oxidase activity"}
{"concept_id": "C4326626", "aliases": ["down-regulation of cytochrome a3 activity", "downregulation of cytochrome a3 activity"], "types": ["T044"], "canonical_name": "down regulation of cytochrome a3 activity"}
{"concept_id": "C4326627", "aliases": ["downregulation of complex IV (mitochondrial electron transport) activity", "down-regulation of complex IV (mitochondrial electron transport) activity"], "types": ["T044"], "canonical_name": "down regulation of complex IV (mitochondrial electron transport) activity"}
{"concept_id": "C4326628", "aliases": ["down-regulation of cbb3-type cytochrome c oxidase", "downregulation of cbb3-type cytochrome c oxidase"], "types": ["T044"], "canonical_name": "down regulation of cbb3-type cytochrome c oxidase"}
{"concept_id": "C4326629", "aliases": ["down-regulation of caa3-type cytochrome c oxidase", "downregulation of caa3-type cytochrome c oxidase"], "types": ["T044"], "canonical_name": "down regulation of caa3-type cytochrome c oxidase"}
{"concept_id": "C4326630", "aliases": ["down-regulation of ba3-type cytochrome c oxidase", "downregulation of ba3-type cytochrome c oxidase"], "types": ["T044"], "canonical_name": "down regulation of ba3-type cytochrome c oxidase"}
{"concept_id": "C4326631", "aliases": ["downregulation of aa3-type cytochrome c oxidase", "down-regulation of aa3-type cytochrome c oxidase"], "types": ["T044"], "canonical_name": "down regulation of aa3-type cytochrome c oxidase"}
{"concept_id": "C4326632", "aliases": [], "types": ["T043"], "canonical_name": "activation of intralumenal vesicle formation"}
{"concept_id": "C4326633", "aliases": [], "types": ["T043"], "canonical_name": "activation of endosome membrane budding"}
{"concept_id": "C4326634", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intralumenal vesicle formation"}
{"concept_id": "C4326635", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endosome membrane budding"}
{"concept_id": "C4326636", "aliases": [], "types": ["T043"], "canonical_name": "activation of endosome vesicle fusion"}
{"concept_id": "C4326637", "aliases": [], "types": ["T043"], "canonical_name": "activation of endosomal vesicle fusion"}
{"concept_id": "C4326638", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endosome vesicle fusion"}
{"concept_id": "C4326639", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of endosomal vesicle fusion"}
{"concept_id": "C4326640", "aliases": ["RASH-SOS1 complex location"], "types": ["T026"], "canonical_name": "RASH-SOS1 complex"}
{"concept_id": "C4326641", "aliases": ["HRAS-SOS1 complex location"], "types": ["T026"], "canonical_name": "HRAS-SOS1 complex"}
{"concept_id": "C4326642", "aliases": [], "types": ["T045"], "canonical_name": "activation of snRNA pseudouridine synthesis"}
{"concept_id": "C4326643", "aliases": [], "types": ["T045"], "canonical_name": "inhibition of snRNA pseudouridine synthesis"}
{"concept_id": "C4326644", "aliases": [], "types": ["T043"], "canonical_name": "dense material formation"}
{"concept_id": "C4326645", "aliases": [], "types": ["T043"], "canonical_name": "dense material assembly"}
{"concept_id": "C4326646", "aliases": [], "types": ["T044"], "canonical_name": "distal appendage of mother centriole formation"}
{"concept_id": "C4326647", "aliases": [], "types": ["T044"], "canonical_name": "distal appendage of centriole formation"}
{"concept_id": "C4326648", "aliases": [], "types": ["T044"], "canonical_name": "distal appendage of centriole assembly"}
{"concept_id": "C4326649", "aliases": [], "types": ["T044"], "canonical_name": "distal appendage of basal body formation"}
{"concept_id": "C4326650", "aliases": [], "types": ["T044"], "canonical_name": "distal appendage of basal body assembly"}
{"concept_id": "C4326651", "aliases": [], "types": ["T044"], "canonical_name": "centriolar distal appendage formation"}
{"concept_id": "C4326652", "aliases": [], "types": ["T044"], "canonical_name": "centriolar distal appendage assembly"}
{"concept_id": "C4326653", "aliases": [], "types": ["T044"], "canonical_name": "Y-shaped linker formation"}
{"concept_id": "C4326654", "aliases": [], "types": ["T044"], "canonical_name": "Y-shaped linker assembly"}
{"concept_id": "C4326655", "aliases": ["Y-shaped fibre formation"], "types": ["T044"], "canonical_name": "Y-shaped fiber formation"}
{"concept_id": "C4326656", "aliases": ["Y-shaped fibre assembly"], "types": ["T044"], "canonical_name": "Y-shaped fiber assembly"}
{"concept_id": "C4326657", "aliases": [], "types": ["T044"], "canonical_name": "Y-shaped assemblage formation"}
{"concept_id": "C4326658", "aliases": [], "types": ["T044"], "canonical_name": "Y-shaped assemblage assembly"}
{"concept_id": "C4326659", "aliases": [], "types": ["T044"], "canonical_name": "Y-link structure formation"}
{"concept_id": "C4326660", "aliases": [], "types": ["T044"], "canonical_name": "Y-link structure assembly"}
{"concept_id": "C4326661", "aliases": [], "types": ["T044"], "canonical_name": "Y-link formation"}
{"concept_id": "C4326662", "aliases": [], "types": ["T044"], "canonical_name": "Y-link assembly"}
{"concept_id": "C4326663", "aliases": [], "types": ["T044"], "canonical_name": "membrane-microtubule complex formation"}
{"concept_id": "C4326664", "aliases": [], "types": ["T044"], "canonical_name": "membrane-microtubule complex assembly"}
{"concept_id": "C4326665", "aliases": ["up-regulation of condensin localization to kinetochore", "upregulation of condensin localization to kinetochore"], "types": ["T043"], "canonical_name": "up regulation of condensin localization to kinetochore"}
{"concept_id": "C4326666", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of condensin localization to kinetochore"}
{"concept_id": "C4326667", "aliases": ["activation of protein localization to kinetochore"], "types": ["T043"], "canonical_name": "activation of protein localisation to kinetochore"}
{"concept_id": "C4326668", "aliases": [], "types": ["T043"], "canonical_name": "activation of condensin localization to kinetochore"}
{"concept_id": "C4326669", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of condensin localization to kinetochore"}
{"concept_id": "C4326670", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of condensin localization to kinetochore"}
{"concept_id": "C4326671", "aliases": ["down-regulation of condensin localization to kinetochore", "downregulation of condensin localization to kinetochore"], "types": ["T043"], "canonical_name": "down regulation of condensin localization to kinetochore"}
{"concept_id": "C4326672", "aliases": [], "types": ["T043"], "canonical_name": "regulation of condensin localization to kinetochore"}
{"concept_id": "C4326673", "aliases": [], "types": ["T045"], "canonical_name": "activation of cohesin unloading"}
{"concept_id": "C4326674", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of cohesin unloading"}
{"concept_id": "C4326675", "aliases": [], "types": ["T043"], "canonical_name": "activation of aggrephagy"}
{"concept_id": "C4326676", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of aggrephagy"}
{"concept_id": "C4326677", "aliases": ["inhibition of morphogenesis of an epithelium"], "types": ["T042"], "canonical_name": "inhibition of epithelium morphogenesis"}
{"concept_id": "C4326678", "aliases": [], "types": ["T043"], "canonical_name": "sphingosine transport"}
{"concept_id": "C4326679", "aliases": [], "types": ["T043"], "canonical_name": "sphingoid transport"}
{"concept_id": "C4326680", "aliases": [], "types": ["T043"], "canonical_name": "phytosphingosine transport"}
{"concept_id": "C4326681", "aliases": [], "types": ["T043"], "canonical_name": "long-chain base transport"}
{"concept_id": "C4326682", "aliases": [], "types": ["T043"], "canonical_name": "dihydrosphingosine transport"}
{"concept_id": "C4326683", "aliases": [], "types": ["T042"], "canonical_name": "dissepiment development"}
{"concept_id": "C4326684", "aliases": [], "types": ["T042"], "canonical_name": "tracheoesophageal ridges formation"}
{"concept_id": "C4326685", "aliases": ["activation of meiosis I spindle assembly checkpoint"], "types": ["T043"], "canonical_name": "activation of meiosis I spindle assembly checkpoint", "definition": "Any process that starts the inactive process of a meiosis I cell cycle spindle assembly checkpoint. [GOC:mah]"}
{"concept_id": "C4326686", "aliases": [], "types": ["T043"], "canonical_name": "activation of mesenchymal stem cell migration"}
{"concept_id": "C4326687", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mesenchymal stem cell migration"}
{"concept_id": "C4326688", "aliases": ["TGFbeta receptor signaling pathway involved in dorsal vessel development", "TGF-beta receptor signalling pathway involved in dorsal vessel development", "transforming growth factor beta receptor signalling pathway involved in dorsal vessel development", "TGFbeta receptor signalling pathway involved in dorsal vessel development", "transforming growth factor beta receptor signaling pathway involved in dorsal vessel development"], "types": ["T044"], "canonical_name": "TGF-beta receptor signaling pathway involved in dorsal vessel development"}
{"concept_id": "C4326689", "aliases": ["TGFbeta receptor signaling pathway involved in cardiac development", "transforming growth factor beta receptor signaling pathway involved in cardiac development", "TGFbeta receptor signalling pathway involved in cardiac development", "TGF-beta receptor signalling pathway involved in cardiac development", "transforming growth factor beta receptor signalling pathway involved in cardiac development"], "types": ["T044"], "canonical_name": "TGF-beta receptor signaling pathway involved in cardiac development"}
{"concept_id": "C4326690", "aliases": [], "types": ["T043"], "canonical_name": "activation of cardiac neural crest cell migration involved in outflow tract morphogenesis"}
{"concept_id": "C4326691", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis"}
{"concept_id": "C4326692", "aliases": ["up-regulation of cardiac myofibril assembly", "up-regulation of cardiac myofibril morphogenesis", "positive regulation of cardiac myofibril development", "positive regulation of cardiac myofibril morphogenesis", "upregulation of cardiac myofibril morphogenesis", "upregulation of heart myofibril assembly", "upregulation of cardiac myofibril assembly", "up regulation of heart myofibril assembly", "up-regulation of heart myofibril assembly", "up regulation of cardiac myofibril development", "positive regulation of heart myofibril assembly", "up regulation of cardiac myofibril morphogenesis", "up regulation of cardiac myofibril assembly", "upregulation of cardiac myofibril development", "up-regulation of cardiac myofibril development"], "types": ["T043"], "canonical_name": "positive regulation of cardiac myofibril assembly", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]"}
{"concept_id": "C4326693", "aliases": [], "types": ["T043"], "canonical_name": "activation of heart myofibril assembly"}
{"concept_id": "C4326694", "aliases": [], "types": ["T043"], "canonical_name": "activation of cardiac myofibril morphogenesis"}
{"concept_id": "C4326695", "aliases": [], "types": ["T043"], "canonical_name": "activation of cardiac myofibril development"}
{"concept_id": "C4326696", "aliases": [], "types": ["T043"], "canonical_name": "activation of cardiac myofibril assembly"}
{"concept_id": "C4326697", "aliases": ["down regulation of heart myofibril assembly", "down regulation of cardiac myofibril development", "down-regulation of cardiac myofibril development", "downregulation of heart myofibril assembly", "negative regulation of heart myofibril assembly", "down-regulation of cardiac myofibril assembly", "down regulation of cardiac myofibril assembly", "down regulation of cardiac myofibril morphogenesis", "down-regulation of cardiac myofibril morphogenesis", "downregulation of cardiac myofibril development", "downregulation of cardiac myofibril morphogenesis", "negative regulation of cardiac myofibril development", "negative regulation of cardiac myofibril morphogenesis", "downregulation of cardiac myofibril assembly", "down-regulation of heart myofibril assembly"], "types": ["T043"], "canonical_name": "negative regulation of cardiac myofibril assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]"}
{"concept_id": "C4326698", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of heart myofibril assembly"}
{"concept_id": "C4326699", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardiac myofibril morphogenesis"}
{"concept_id": "C4326700", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardiac myofibril development"}
{"concept_id": "C4326701", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardiac myofibril assembly"}
{"concept_id": "C4326702", "aliases": [], "types": ["T043"], "canonical_name": "regulation of heart myofibril assembly"}
{"concept_id": "C4326703", "aliases": [], "types": ["T043"], "canonical_name": "activation of macropinocytosis"}
{"concept_id": "C4326704", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of macropinocytosis"}
{"concept_id": "C4326705", "aliases": [], "types": ["T043"], "canonical_name": "regulation of clathrin-independent pinocytosis"}
{"concept_id": "C4326706", "aliases": [], "types": ["T043"], "canonical_name": "activation of intestinal epithelial cell development"}
{"concept_id": "C4326707", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of intestinal epithelial cell development"}
{"concept_id": "C4326708", "aliases": [], "types": ["T043"], "canonical_name": "activation of neural crest cell fate specification"}
{"concept_id": "C4326709", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neural crest cell fate specification"}
{"concept_id": "C4326710", "aliases": [], "types": ["T043"], "canonical_name": "activation of neural crest cell differentiation"}
{"concept_id": "C4326711", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of neural crest cell differentiation"}
{"concept_id": "C4326712", "aliases": ["up-regulation of stress-activated AMP-activated protein kinase signaling cascade", "up regulation of stress-activated AMP-activated protein kinase signaling cascade", "upregulation of stress-activated AMP-activated protein kinase signaling cascade"], "types": ["T044"], "canonical_name": "positive regulation of stress-activated AMP-activated protein kinase signaling cascade"}
{"concept_id": "C4326713", "aliases": [], "types": ["T044"], "canonical_name": "activation of stress-activated AMP-activated protein kinase signaling cascade"}
{"concept_id": "C4326714", "aliases": [], "types": ["T044"], "canonical_name": "activation of CAMKK-AMPK signaling cascade"}
{"concept_id": "C4326715", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of stress-activated AMP-activated protein kinase signaling cascade"}
{"concept_id": "C4326716", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of stress-activated AMP-activated protein kinase signaling cascade"}
{"concept_id": "C4326717", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of CAMKK-AMPK signaling cascade"}
{"concept_id": "C4326718", "aliases": ["downregulation of stress-activated AMP-activated protein kinase signaling cascade", "down-regulation of stress-activated AMP-activated protein kinase signaling cascade"], "types": ["T044"], "canonical_name": "down regulation of stress-activated AMP-activated protein kinase signaling cascade"}
{"concept_id": "C4326719", "aliases": [], "types": ["T044"], "canonical_name": "regulation of stress-activated AMP-activated protein kinase signaling cascade"}
{"concept_id": "C4326720", "aliases": ["vascular smooth muscle cell apoptosis", "vascular smooth muscle cell apoptotic process", "vascular associated smooth muscle cell apoptosis", "VSMC apoptotic process", "VSMC apoptosis"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell apoptotic process", "definition": "Any apoptotic process in a vascular associated smooth muscle cell. [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]"}
{"concept_id": "C4326721", "aliases": ["Factor VII - TF complex location"], "types": ["T026"], "canonical_name": "Factor VII - TF complex"}
{"concept_id": "C4326722", "aliases": [], "types": ["T042"], "canonical_name": "Lower's ring morphogenesis"}
{"concept_id": "C4326723", "aliases": [], "types": ["T042"], "canonical_name": "coronary tendon morphogenesis"}
{"concept_id": "C4326724", "aliases": [], "types": ["T042"], "canonical_name": "atrioventricular ring morphogenesis"}
{"concept_id": "C4326725", "aliases": [], "types": ["T042"], "canonical_name": "aortic annulus morphogenesis"}
{"concept_id": "C4326726", "aliases": ["anulus fibrosus cordis morphogenesis"], "types": ["T042"], "canonical_name": "annulus fibrosus cordis morphogenesis"}
{"concept_id": "C4326727", "aliases": ["up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process", "upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326728", "aliases": ["up-regulation of ERBB1 signaling pathway involved in cardiac process", "upregulation of ERBB1 signaling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "up regulation of ERBB1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326729", "aliases": ["upregulation of EGF receptor signalling pathway involved in cardiac process", "up regulation of EGF receptor signalling pathway involved in cardiac process", "up regulation of EGFR signaling pathway involved in cardiac process", "up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process", "up regulation of epidermal growth factor receptor signalling pathway involved in cardiac process", "up-regulation of EGF receptor signaling pathway involved in cardiac process", "up-regulation of EGFR signaling pathway involved in cardiac process", "up-regulation of EGF receptor signalling pathway involved in cardiac process", "up-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process", "upregulation of EGF receptor signaling pathway involved in cardiac process", "upregulation of epidermal growth factor receptor signalling pathway involved in cardiac process", "up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process", "upregulation of EGFR signaling pathway involved in cardiac process", "upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "up regulation of EGF receptor signaling pathway involved in cardiac process"}
{"concept_id": "C4326730", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326731", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ERBB1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326732", "aliases": ["positive regulation of EGFR signaling pathway involved in cardiac process", "positive regulation of EGF receptor signalling pathway involved in cardiac process", "positive regulation of epidermal growth factor receptor signalling pathway involved in cardiac process", "positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "positive regulation of EGF receptor signaling pathway involved in cardiac process"}
{"concept_id": "C4326733", "aliases": [], "types": ["T044"], "canonical_name": "activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process"}
{"concept_id": "C4326734", "aliases": [], "types": ["T044"], "canonical_name": "activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326735", "aliases": [], "types": ["T044"], "canonical_name": "activation of ERBB1 signaling pathway involved in heart process"}
{"concept_id": "C4326736", "aliases": [], "types": ["T044"], "canonical_name": "activation of ERBB1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326737", "aliases": ["activation of EGF receptor signalling pathway involved in heart process", "activation of EGFR signaling pathway involved in heart process", "activation of epidermal growth factor receptor signalling pathway involved in heart process", "activation of epidermal growth factor receptor signaling pathway involved in heart process"], "types": ["T043"], "canonical_name": "activation of EGF receptor signaling pathway involved in heart process"}
{"concept_id": "C4326738", "aliases": ["activation of epidermal growth factor receptor signalling pathway involved in cardiac process", "activation of epidermal growth factor receptor signaling pathway involved in cardiac process", "activation of EGF receptor signalling pathway involved in cardiac process", "activation of EGFR signaling pathway involved in cardiac process"], "types": ["T043"], "canonical_name": "activation of EGF receptor signaling pathway involved in cardiac process"}
{"concept_id": "C4326739", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326740", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ERBB1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326741", "aliases": ["down-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process", "negative regulation of EGF receptor signalling pathway involved in cardiac process", "down regulation of epidermal growth factor receptor signalling pathway involved in cardiac process", "downregulation of EGFR signaling pathway involved in cardiac process", "negative regulation of EGFR signaling pathway involved in cardiac process", "negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process", "downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process", "negative regulation of EGF receptor signaling pathway involved in cardiac process", "down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process", "down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process", "negative regulation of epidermal growth factor receptor signalling pathway involved in cardiac process", "downregulation of epidermal growth factor receptor signalling pathway involved in cardiac process", "down-regulation of EGFR signaling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "down regulation of EGFR signaling pathway involved in cardiac process"}
{"concept_id": "C4326742", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process"}
{"concept_id": "C4326743", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326744", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ERBB1 signaling pathway involved in heart process"}
{"concept_id": "C4326745", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of ERBB1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326746", "aliases": ["inhibition of epidermal growth factor receptor signaling pathway involved in heart process", "inhibition of EGF receptor signalling pathway involved in heart process", "inhibition of epidermal growth factor receptor signalling pathway involved in heart process", "inhibition of EGFR signaling pathway involved in heart process"], "types": ["T043"], "canonical_name": "inhibition of EGF receptor signaling pathway involved in heart process"}
{"concept_id": "C4326747", "aliases": ["inhibition of EGFR signaling pathway involved in cardiac process", "inhibition of epidermal growth factor receptor signalling pathway involved in cardiac process", "inhibition of EGF receptor signalling pathway involved in cardiac process", "inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process"], "types": ["T043"], "canonical_name": "inhibition of EGF receptor signaling pathway involved in cardiac process"}
{"concept_id": "C4326748", "aliases": ["downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process", "down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326749", "aliases": ["downregulation of ERBB1 signaling pathway involved in cardiac process", "down-regulation of ERBB1 signaling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "down regulation of ERBB1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326750", "aliases": ["downregulation of EGF receptor signaling pathway involved in cardiac process", "downregulation of EGF receptor signalling pathway involved in cardiac process", "down-regulation of EGF receptor signaling pathway involved in cardiac process", "down-regulation of EGF receptor signalling pathway involved in cardiac process", "down regulation of EGF receptor signalling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "down regulation of EGF receptor signaling pathway involved in cardiac process"}
{"concept_id": "C4326751", "aliases": [], "types": ["T044"], "canonical_name": "regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326752", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ERBB1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326753", "aliases": ["regulation of EGF receptor signalling pathway involved in cardiac process", "regulation of epidermal growth factor receptor signaling pathway involved in cardiac process", "regulation of EGFR signaling pathway involved in cardiac process", "regulation of epidermal growth factor receptor signalling pathway involved in cardiac process"], "types": ["T044"], "canonical_name": "regulation of EGF receptor signaling pathway involved in cardiac process"}
{"concept_id": "C4326754", "aliases": ["activation of retrograde transport, endosome to Golgi"], "types": ["T043"], "canonical_name": "activation of retrograde (endosome to Golgi) transport"}
{"concept_id": "C4326755", "aliases": ["inhibition of retrograde transport, endosome to Golgi"], "types": ["T043"], "canonical_name": "inhibition of retrograde (endosome to Golgi) transport"}
{"concept_id": "C4326756", "aliases": [], "types": ["T042"], "canonical_name": "activation of epithelial tube formation"}
{"concept_id": "C4326757", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of epithelial tube formation"}
{"concept_id": "C4326758", "aliases": [], "types": ["T044"], "canonical_name": "activation of proton-transporting ATP synthase activity, rotational mechanism"}
{"concept_id": "C4326759", "aliases": [], "types": ["T044"], "canonical_name": "activation of hydrogen ion transporting two-sector ATPase activity"}
{"concept_id": "C4326760", "aliases": [], "types": ["T044"], "canonical_name": "activation of hydrogen ion transporting ATP synthase activity, rotational mechanism"}
{"concept_id": "C4326761", "aliases": [], "types": ["T044"], "canonical_name": "activation of hydrogen ion translocating F-type ATPase activity"}
{"concept_id": "C4326762", "aliases": [], "types": ["T044"], "canonical_name": "activation of H+-transporting ATP synthase activity"}
{"concept_id": "C4326763", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of proton-transporting ATP synthase activity, rotational mechanism"}
{"concept_id": "C4326764", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hydrogen ion transporting two-sector ATPase activity"}
{"concept_id": "C4326765", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hydrogen ion transporting ATP synthase activity, rotational mechanism"}
{"concept_id": "C4326766", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of hydrogen ion translocating F-type ATPase activity"}
{"concept_id": "C4326767", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of H+-transporting ATP synthase activity"}
{"concept_id": "C4326768", "aliases": [], "types": ["T043"], "canonical_name": "activation of establishment or maintenance of chromatin architecture"}
{"concept_id": "C4326769", "aliases": ["activation of chromatin organization"], "types": ["T043"], "canonical_name": "activation of chromatin organisation"}
{"concept_id": "C4326770", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of establishment or maintenance of chromatin architecture"}
{"concept_id": "C4326771", "aliases": ["inhibition of chromatin organization"], "types": ["T043"], "canonical_name": "inhibition of chromatin organisation"}
{"concept_id": "C4326772", "aliases": [], "types": ["T043"], "canonical_name": "activation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"}
{"concept_id": "C4326773", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"}
{"concept_id": "C4326774", "aliases": ["upregulation of nitrosative stress-induced apoptosis", "up-regulation of nitrosative stress-induced apoptosis", "up regulation of nitrosative stress-induced apoptosis"], "types": ["T043"], "canonical_name": "positive regulation of nitrosative stress-induced apoptosis"}
{"concept_id": "C4326775", "aliases": ["activation of nitrosative stress-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "activation of intrinsic apoptotic signaling pathway in response to nitrosative stress"}
{"concept_id": "C4326776", "aliases": [], "types": ["T043"], "canonical_name": "activation of nitrosative stress-induced apoptosis"}
{"concept_id": "C4326777", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of nitrosative stress-induced apoptosis"}
{"concept_id": "C4326778", "aliases": ["inhibition of nitrosative stress-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "inhibition of intrinsic apoptotic signaling pathway in response to nitrosative stress"}
{"concept_id": "C4326779", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of nitrosative stress-induced apoptosis"}
{"concept_id": "C4326780", "aliases": ["downregulation of nitrosative stress-induced apoptosis", "down-regulation of nitrosative stress-induced apoptosis"], "types": ["T043"], "canonical_name": "down regulation of nitrosative stress-induced apoptosis"}
{"concept_id": "C4326781", "aliases": [], "types": ["T043"], "canonical_name": "regulation of nitrosative stress-induced apoptosis"}
{"concept_id": "C4326782", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNA binding transcription factor activity"}
{"concept_id": "C4326783", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA binding transcription factor activity"}
{"concept_id": "C4326784", "aliases": ["receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process"], "types": ["T043"], "canonical_name": "ERBB1 signaling pathway involved in cardiac process"}
{"concept_id": "C4326785", "aliases": ["epidermal growth factor receptor signalling pathway involved in cardiac process", "EGF receptor signalling pathway involved in cardiac process", "EGFR signaling pathway involved in cardiac process", "epidermal growth factor receptor signaling pathway involved in cardiac process"], "types": ["T043"], "canonical_name": "EGF receptor signaling pathway involved in cardiac process"}
{"concept_id": "C4326786", "aliases": [], "types": ["T044"], "canonical_name": "activation of aspartic-type peptidase activity"}
{"concept_id": "C4326787", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of aspartic-type peptidase activity"}
{"concept_id": "C4326788", "aliases": ["activation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "activation of canonical Wnt signaling pathway involved in osteoblast differentiation", "activation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation"], "types": ["T043"], "canonical_name": "activation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation"}
{"concept_id": "C4326789", "aliases": ["inhibition of canonical Wnt signaling pathway involved in osteoblast differentiation", "inhibition of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "inhibition of canonical Wnt receptor signalling pathway involved in osteoblast differentiation"], "types": ["T043"], "canonical_name": "inhibition of canonical Wnt receptor signaling pathway involved in osteoblast differentiation"}
{"concept_id": "C4326790", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to L-glutamate(1-)"}
{"concept_id": "C4326791", "aliases": ["cellular response to protirelin", "cellular response to TRH"], "types": ["T043"], "canonical_name": "cellular response to thyrotropin-releasing hormone", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. [GO_REF:0000071, GOC:TermGenie, PMID:21382270]"}
{"concept_id": "C4326792", "aliases": [], "types": ["T043"], "canonical_name": "activation of adhesion of symbiont to host epithelial cell"}
{"concept_id": "C4326793", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of adhesion of symbiont to host epithelial cell"}
{"concept_id": "C4326794", "aliases": ["response to TRH", "response to protirelin"], "types": ["T040"], "canonical_name": "response to thyrotropin-releasing hormone", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:21382270]"}
{"concept_id": "C4326795", "aliases": [], "types": ["T042"], "canonical_name": "pericardium visceral mesothelium morphogenesis"}
{"concept_id": "C4326796", "aliases": [], "types": ["T042"], "canonical_name": "ependymal canal morphogenesis"}
{"concept_id": "C4326797", "aliases": [], "types": ["T042"], "canonical_name": "canalis atrioventricularis morphogenesis"}
{"concept_id": "C4326798", "aliases": [], "types": ["T043"], "canonical_name": "activation of platelet formation"}
{"concept_id": "C4326799", "aliases": [], "types": ["T043"], "canonical_name": "activation of platelet extrusion"}
{"concept_id": "C4326800", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of platelet formation"}
{"concept_id": "C4326801", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of platelet extrusion"}
{"concept_id": "C4326802", "aliases": [], "types": ["T044"], "canonical_name": "activation of RNA binding"}
{"concept_id": "C4326803", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of RNA binding"}
{"concept_id": "C4326804", "aliases": [], "types": ["T043"], "canonical_name": "activation of fibroblast chemotaxis"}
{"concept_id": "C4326805", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of fibroblast chemotaxis"}
{"concept_id": "C4326806", "aliases": [], "types": ["T043"], "canonical_name": "activation of heart cell differentiation"}
{"concept_id": "C4326807", "aliases": [], "types": ["T043"], "canonical_name": "activation of cardiocyte differentiation"}
{"concept_id": "C4326808", "aliases": [], "types": ["T043"], "canonical_name": "activation of cardiac cell differentiation"}
{"concept_id": "C4326809", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of heart cell differentiation"}
{"concept_id": "C4326810", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardiocyte differentiation"}
{"concept_id": "C4326811", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cardiac cell differentiation"}
{"concept_id": "C4326812", "aliases": ["up-regulation of hydrogen peroxide-mediated cell death", "up regulation of hydrogen peroxide-mediated cell death", "upregulation of hydrogen peroxide-mediated cell death"], "types": ["T043"], "canonical_name": "positive regulation of hydrogen peroxide-mediated cell death"}
{"concept_id": "C4326813", "aliases": ["activation of cell death in response to hydrogen peroxide", "activation of hydrogen peroxide-mediated cell death"], "types": ["T043"], "canonical_name": "activation of cell death in response to H2O2"}
{"concept_id": "C4326814", "aliases": [], "types": ["T042"], "canonical_name": "activation of connective tissue replacement"}
{"concept_id": "C4326815", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of connective tissue replacement"}
{"concept_id": "C4326820", "aliases": [], "types": ["T043"], "canonical_name": "activation of chloroplast fission"}
{"concept_id": "C4326821", "aliases": [], "types": ["T043"], "canonical_name": "activation of chloroplast division"}
{"concept_id": "C4326822", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chloroplast fission"}
{"concept_id": "C4326823", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chloroplast division"}
{"concept_id": "C4326824", "aliases": [], "types": ["T043"], "canonical_name": "regulation of first meiotic metaphase/anaphase transition"}
{"concept_id": "C4326825", "aliases": [], "types": ["T044"], "canonical_name": "activation of serine/threonine specific protein phosphatase activity"}
{"concept_id": "C4326826", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein serine/threonine phosphatase activity"}
{"concept_id": "C4326827", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of serine/threonine specific protein phosphatase activity"}
{"concept_id": "C4326828", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein serine/threonine phosphatase activity"}
{"concept_id": "C4326829", "aliases": [], "types": ["T044"], "canonical_name": "activation of urease activity"}
{"concept_id": "C4326830", "aliases": [], "types": ["T044"], "canonical_name": "activation of urea amidohydrolase activity"}
{"concept_id": "C4326831", "aliases": [], "types": ["T042"], "canonical_name": "activation of cardiac muscle tissue regeneration"}
{"concept_id": "C4326832", "aliases": [], "types": ["T042"], "canonical_name": "inhibition of cardiac muscle tissue regeneration"}
{"concept_id": "C4326833", "aliases": [], "types": ["T043"], "canonical_name": "activation of vascular smooth muscle cell dedifferentiation"}
{"concept_id": "C4326834", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of vascular smooth muscle cell dedifferentiation"}
{"concept_id": "C4326835", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein recruitment to phagosome"}
{"concept_id": "C4326836", "aliases": ["activation of protein localization to phagocytic vesicle"], "types": ["T043"], "canonical_name": "activation of protein localisation to phagocytic vesicle"}
{"concept_id": "C4326837", "aliases": ["activation of protein localization in phagocytic vesicle"], "types": ["T043"], "canonical_name": "activation of protein localisation in phagocytic vesicle"}
{"concept_id": "C4326838", "aliases": [], "types": ["T043"], "canonical_name": "activation of protein localisation to phagosome"}
{"concept_id": "C4326839", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein recruitment to phagosome"}
{"concept_id": "C4326840", "aliases": ["inhibition of protein localization to phagocytic vesicle"], "types": ["T043"], "canonical_name": "inhibition of protein localisation to phagocytic vesicle"}
{"concept_id": "C4326841", "aliases": ["inhibition of protein localization in phagocytic vesicle"], "types": ["T043"], "canonical_name": "inhibition of protein localisation in phagocytic vesicle"}
{"concept_id": "C4326842", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of protein localisation to phagosome"}
{"concept_id": "C4326843", "aliases": ["up-regulation of APC-fizzy related complex activity", "upregulation of APC-fizzy related complex activity"], "types": ["T043"], "canonical_name": "up regulation of APC-fizzy related complex activity"}
{"concept_id": "C4326844", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of APC-fizzy related complex activity"}
{"concept_id": "C4326845", "aliases": [], "types": ["T043"], "canonical_name": "activation of anaphase-promoting complex activity"}
{"concept_id": "C4326846", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ferrous iron import into cell"}
{"concept_id": "C4326847", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ferrous iron import into cell"}
{"concept_id": "C4326857", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to DIF1"}
{"concept_id": "C4326858", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to DIF-1"}
{"concept_id": "C4326859", "aliases": [], "types": ["T043"], "canonical_name": "response to DIF-1"}
{"concept_id": "C4326860", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tyrosine phosphorylation of JAK1 protein"}
{"concept_id": "C4326861", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of activation of JAK1 protein"}
{"concept_id": "C4326862", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of tyrosine phosphorylation of JAK1 protein"}
{"concept_id": "C4326863", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of activation of JAK1 protein"}
{"concept_id": "C4326864", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of activation of JAK1 kinase activity"}
{"concept_id": "C4326865", "aliases": ["downregulation of tyrosine phosphorylation of JAK1 protein", "down-regulation of tyrosine phosphorylation of JAK1 protein"], "types": ["T044"], "canonical_name": "down regulation of tyrosine phosphorylation of JAK1 protein"}
{"concept_id": "C4326866", "aliases": ["down-regulation of activation of JAK1 protein", "downregulation of activation of JAK1 protein"], "types": ["T044"], "canonical_name": "down regulation of activation of JAK1 protein"}
{"concept_id": "C4326867", "aliases": ["down-regulation of activation of JAK1 kinase activity", "downregulation of activation of JAK1 kinase activity"], "types": ["T044"], "canonical_name": "down regulation of activation of JAK1 kinase activity"}
{"concept_id": "C4326868", "aliases": [], "types": ["T043"], "canonical_name": "proton export from cell"}
{"concept_id": "C4326869", "aliases": [], "types": ["T043"], "canonical_name": "hydrogen ion export from cell"}
{"concept_id": "C4326870", "aliases": ["AUM", "asymmetric unit membrane"], "types": ["T026"], "canonical_name": "apical plasma membrane urothelial plaque", "definition": "A scallop-shaped plaque, also referred to as an asymmetric unit membrane (AUM), found in the apical plasma membrane of urothelial superficial (umbrella) cells which form a a barrier to the passage of water and soluble toxic compounds found in urine. The plaques are thickened regions of membrane composed of uroplakin transmembrane proteins which form a crystalline array. [GOC:krc, PMID:21468280, PMID:21887288]"}
{"concept_id": "C4326871", "aliases": ["homotrimer of amyloid beta protein"], "types": ["T026"], "canonical_name": "amyloid beta homotrimer"}
{"concept_id": "C4326872", "aliases": ["homooligomer of amyloid beta protein"], "types": ["T026"], "canonical_name": "amyloid beta homooligomer"}
{"concept_id": "C4326873", "aliases": ["homodimer of amyloid beta protein"], "types": ["T026"], "canonical_name": "amyloid beta homodimer"}
{"concept_id": "C4326874", "aliases": ["heterotrimer of amyloid beta protein"], "types": ["T026"], "canonical_name": "amyloid beta heterotrimer"}
{"concept_id": "C4326875", "aliases": ["heterooligomer of amyloid beta protein"], "types": ["T026"], "canonical_name": "amyloid beta heterooligomer"}
{"concept_id": "C4326876", "aliases": ["heterodimer of amyloid beta protein"], "types": ["T026"], "canonical_name": "amyloid beta heterodimer"}
{"concept_id": "C4326877", "aliases": ["amyloid-beta protein 42 complex location"], "types": ["T026"], "canonical_name": "amyloid-beta protein 42 complex"}
{"concept_id": "C4326878", "aliases": ["amyloid-beta protein 40/42 complex location"], "types": ["T026"], "canonical_name": "amyloid-beta protein 40/42 complex"}
{"concept_id": "C4326879", "aliases": ["amyloid-beta protein 40 complex location"], "types": ["T026"], "canonical_name": "amyloid-beta protein 40 complex"}
{"concept_id": "C4326880", "aliases": [], "types": ["T026"], "canonical_name": "amyloid beta trimer"}
{"concept_id": "C4326881", "aliases": [], "types": ["T026"], "canonical_name": "amyloid beta oligomer"}
{"concept_id": "C4326882", "aliases": [], "types": ["T026"], "canonical_name": "amyloid beta dimer"}
{"concept_id": "C4326883", "aliases": ["ADDL complex location"], "types": ["T026"], "canonical_name": "ADDL complex"}
{"concept_id": "C4326884", "aliases": ["Abeta-derived diffusible ligand complex location"], "types": ["T026"], "canonical_name": "Abeta-derived diffusible ligand complex"}
{"concept_id": "C4326885", "aliases": [], "types": ["T044"], "canonical_name": "postsynaptic process involved in chemical synaptic transmission"}
{"concept_id": "C4326886", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial calcium ion export"}
{"concept_id": "C4326888", "aliases": ["quiescent cell microtubule bundle"], "types": ["T026"], "canonical_name": "quiescent cell MT bundle"}
{"concept_id": "C4326889", "aliases": [], "types": ["T026"], "canonical_name": "Q-MT bundle"}
{"concept_id": "C4326890", "aliases": ["viral penetration via permeabilization of host membrane"], "types": ["T043"], "canonical_name": "viral penetration via permeabilization of host membrane"}
{"concept_id": "C4326891", "aliases": [], "types": ["T043"], "canonical_name": "fusion of viral membrane with host outer membrane"}
{"concept_id": "C4326892", "aliases": [], "types": ["T043"], "canonical_name": "disassembly by virus of outer membrane lipopolysaccharide during viral entry"}
{"concept_id": "C4326893", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic to postsynaptic early endosome membrane"}
{"concept_id": "C4326894", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic to postsynaptic endosome membrane"}
{"concept_id": "C4326895", "aliases": ["intrinsic to postsynaptic specialization membrane"], "types": ["T026"], "canonical_name": "intrinsic to postsynaptic specialization membrane"}
{"concept_id": "C4326896", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic to postsynaptic acive zone membrane"}
{"concept_id": "C4326897", "aliases": ["intrinsic to presynaptic acive zone membrane"], "types": ["T026"], "canonical_name": "intrinsic to presynaptic acive zone membrane"}
{"concept_id": "C4326898", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic to postsynaptic membrane"}
{"concept_id": "C4326899", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic to presynaptic membrane"}
{"concept_id": "C4326900", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic endosomal recycling compartment"}
{"concept_id": "C4326901", "aliases": ["multiciliogenesis"], "types": ["T043"], "canonical_name": "multiciliogenesis"}
{"concept_id": "C4326902", "aliases": ["multiciliation"], "types": ["T043"], "canonical_name": "multiciliation"}
{"concept_id": "C4326903", "aliases": [], "types": ["T043"], "canonical_name": "deuterosome-mediated centriole biogenesis"}
{"concept_id": "C4326904", "aliases": [], "types": ["T043"], "canonical_name": "deuterosome pathway"}
{"concept_id": "C4326905", "aliases": [], "types": ["T043"], "canonical_name": "deuterosomal basal body biogenesis"}
{"concept_id": "C4326906", "aliases": [], "types": ["T043"], "canonical_name": "membrane curvature"}
{"concept_id": "C4326907", "aliases": [], "types": ["T039"], "canonical_name": "sporangium formation"}
{"concept_id": "C4326908", "aliases": [], "types": ["T042"], "canonical_name": "regulation of vasodilation"}
{"concept_id": "C4326909", "aliases": [], "types": ["T040"], "canonical_name": "regulation of vasodilatation"}
{"concept_id": "C4326910", "aliases": [], "types": ["T039"], "canonical_name": "urate excretion"}
{"concept_id": "C4326911", "aliases": [], "types": ["T043"], "canonical_name": "de novo ciliary basal body assembly"}
{"concept_id": "C4326912", "aliases": [], "types": ["T043"], "canonical_name": "de novo centriole amplification"}
{"concept_id": "C4326913", "aliases": [], "types": ["T043"], "canonical_name": "de novo basal body generation"}
{"concept_id": "C4326914", "aliases": [], "types": ["T043"], "canonical_name": "de novo basal body biogenesis"}
{"concept_id": "C4326915", "aliases": [], "types": ["T043"], "canonical_name": "de novo basal body assembly"}
{"concept_id": "C4326916", "aliases": [], "types": ["T043"], "canonical_name": "de novo basal body amplification"}
{"concept_id": "C4326917", "aliases": [], "types": ["T043"], "canonical_name": "acentriolar basal body biogenesis"}
{"concept_id": "C4326918", "aliases": [], "types": ["T040"], "canonical_name": "mycelium developmental competence"}
{"concept_id": "C4326919", "aliases": [], "types": ["T040"], "canonical_name": "fertile mycelium formation"}
{"concept_id": "C4326920", "aliases": [], "types": ["T040"], "canonical_name": "aerial hyphal growth"}
{"concept_id": "C4326921", "aliases": ["intraluminal vesicle assembly"], "types": ["T043"], "canonical_name": "ILV assembly"}
{"concept_id": "C4326922", "aliases": ["non-motile 9+2 cilium", "9+2 immotile cilium"], "types": ["T026"], "canonical_name": "9+2 non-motile cilium", "definition": "A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme). [GOC:cilia, PMID:21307074, PMID:22118931]"}
{"concept_id": "C4326923", "aliases": [], "types": ["T026"], "canonical_name": "sensory cilium"}
{"concept_id": "C4326924", "aliases": [], "types": ["T026"], "canonical_name": "conventional motile cilium"}
{"concept_id": "C4326925", "aliases": [], "types": ["T043"], "canonical_name": "calcineurin signaling"}
{"concept_id": "C4326926", "aliases": ["neural tissue regeneration"], "types": ["T042"], "definition": "The regrowth of neural tissue following its loss or destruction. [Wikipedia:Neuroregeneration]", "canonical_name": "neuroregeneration"}
{"concept_id": "C4326927", "aliases": [], "types": ["T044"], "canonical_name": "disordered protein domain specific binding"}
{"concept_id": "C4326928", "aliases": ["copper ion transport across blood-CSF barrier", "copper ion transport across blood/cerebrospinal fluid barrier", "copper ion transport across blood/CSF barrier", "copper ion transport across BCB", "copper ion transport across BCSFB"], "types": ["T043"], "canonical_name": "copper ion transport across blood-cerebrospinal fluid barrier", "definition": "OBSOLETE. The directed movement of copper ions passing through the blood-cerebrospinal fluid barrier. [PMID:24614235]"}
{"concept_id": "C4326929", "aliases": ["copper ion transport across BBB"], "types": ["T043"], "canonical_name": "copper ion transport across blood-brain barrier", "definition": "The directed movement of copper (Cu) ions passing through the blood-brain barrier. [GOC:sl, PMID:24614235]"}
{"concept_id": "C4326930", "aliases": [], "types": ["T043"], "canonical_name": "anchoring of the basal body to the plasma membrane"}
{"concept_id": "C4326931", "aliases": [], "types": ["T026"], "canonical_name": "Tenascin-W"}
{"concept_id": "C4326932", "aliases": [], "types": ["T026"], "canonical_name": "Tenascin-N"}
{"concept_id": "C4326933", "aliases": ["chromatin loop assembly", "DNA loop extrusion"], "types": ["T045"], "canonical_name": "chromatin looping", "definition": "A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome. [PMID:32213323]"}
{"concept_id": "C4326934", "aliases": [], "types": ["T026"], "canonical_name": "Midbody ring"}
{"concept_id": "C4326935", "aliases": [], "types": ["T043"], "canonical_name": "receptor-mediated endocytosis involved in intracellular cholesterol transport"}
{"concept_id": "C4326936", "aliases": ["CATCHR family complex location"], "types": ["T026"], "canonical_name": "CATCHR family complex"}
{"concept_id": "C4326937", "aliases": [], "types": ["T043"], "canonical_name": "programmed necrosis"}
{"concept_id": "C4326938", "aliases": ["cellular response to DIF2"], "types": ["T043"], "canonical_name": "cellular response to DIF-2"}
{"concept_id": "C4326939", "aliases": ["ERV41-ERV46 retrograde receptor complex location"], "types": ["T026"], "canonical_name": "ERV41-ERV46 retrograde receptor complex"}
{"concept_id": "C4326940", "aliases": [], "types": ["T043"], "canonical_name": "peptide-mediated antimicrobial humoral response"}
{"concept_id": "C4326941", "aliases": ["restructuring of BTB", "restructuring of blood-testis barrier"], "types": ["T042"], "canonical_name": "blood testis barrier restructuring"}
{"concept_id": "C4326942", "aliases": ["microtubule organizing center polarity"], "types": ["T043"], "canonical_name": "MTOC polarity"}
{"concept_id": "C4326943", "aliases": ["FET5-FTH1 high-affinity iron exporter complex", "FET5-FTH1 high affinity iron exporter complex location", "FET5-FTH1 high-affinity iron exporter complex location"], "types": ["T026"], "canonical_name": "FET5-FTH1 high affinity iron exporter complex"}
{"concept_id": "C4326944", "aliases": [], "types": ["T043"], "canonical_name": "intracellular ciliogenesis"}
{"concept_id": "C4326945", "aliases": ["nucleosome bridging complex location"], "types": ["T026"], "canonical_name": "nucleosome bridging complex"}
{"concept_id": "C4326946", "aliases": ["Epidermal Growth Factor repeat binding"], "types": ["T044"], "canonical_name": "EGF repeat binding", "definition": "Binding to Epidermal Growth Factor (EGF) repeats. [GOC:25700513, GOC:dph, PMID:25155514]"}
{"concept_id": "C4326947", "aliases": [], "types": ["T044"], "canonical_name": "Epidermal growth factor domain binding"}
{"concept_id": "C4326948", "aliases": [], "types": ["T044"], "canonical_name": "lysostaphin activity"}
{"concept_id": "C4326949", "aliases": ["gluconate pathway"], "types": ["T044"], "canonical_name": "gluconate pathway"}
{"concept_id": "C4326951", "aliases": [], "types": ["T044"], "canonical_name": "APC-Cdc20 complex activity"}
{"concept_id": "C4326952", "aliases": [], "types": ["T043"], "canonical_name": "nodal cilium movement involved in determination of left/right asymmetry"}
{"concept_id": "C4326953", "aliases": [], "types": ["T043"], "canonical_name": "Kuppfer's vesicle cilium movement involved in determination of left/right asymmetry"}
{"concept_id": "C4326954", "aliases": [], "types": ["T043"], "canonical_name": "cilium biogenesis"}
{"concept_id": "C4326955", "aliases": [], "types": ["T042"], "canonical_name": "regulation of relaxation of vascular smooth muscle"}
{"concept_id": "C4326956", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of relaxation of vascular smooth muscle"}
{"concept_id": "C4326957", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of relaxation of vascular smooth muscle"}
{"concept_id": "C4326959", "aliases": ["NETO"], "types": ["T043"], "canonical_name": "new end take off"}
{"concept_id": "C4326960", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell elongation"}
{"concept_id": "C4326961", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell elongation"}
{"concept_id": "C4326962", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell elongation"}
{"concept_id": "C4326970", "aliases": [], "types": ["T040"], "canonical_name": "sorocarp spore head morphogenesis"}
{"concept_id": "C4326971", "aliases": ["initiation of an animal organ primordium"], "types": ["T042"], "canonical_name": "animal organ primordium initiation"}
{"concept_id": "C4326972", "aliases": [], "types": ["T044"], "canonical_name": "aldehyde dehydrogenase (pyrroloquinoline-quinone)"}
{"concept_id": "C4326973", "aliases": ["coenzyme Q-cytochrome c reductase complex location"], "types": ["T026"], "canonical_name": "coenzyme Q-cytochrome c reductase complex"}
{"concept_id": "C4326974", "aliases": ["coenzyme Q-cytochrome c oxidoreductase complex location"], "types": ["T026"], "canonical_name": "coenzyme Q-cytochrome c oxidoreductase complex"}
{"concept_id": "C4326975", "aliases": [], "types": ["T043"], "canonical_name": "nodal cilium formation"}
{"concept_id": "C4326976", "aliases": [], "types": ["T043"], "canonical_name": "nodal cilium assembly"}
{"concept_id": "C4326977", "aliases": ["motile primary cilium formation"], "types": ["T043"], "canonical_name": "motile primary cilia formation"}
{"concept_id": "C4326978", "aliases": ["motile primary cilium assembly"], "types": ["T043"], "canonical_name": "motile primary cilia assembly"}
{"concept_id": "C4326979", "aliases": [], "types": ["T043"], "canonical_name": "asexual sporulation resulting in the formation of a viable spore"}
{"concept_id": "C4326980", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein phosphatase type 2B activity"}
{"concept_id": "C4326981", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcineurin activity"}
{"concept_id": "C4326982", "aliases": [], "types": ["T044"], "canonical_name": "activation of JAK2 protein"}
{"concept_id": "C4326983", "aliases": [], "types": ["T044"], "canonical_name": "activation of JAK2 kinase activity"}
{"concept_id": "C4326984", "aliases": [], "types": ["T044"], "canonical_name": "activation of JAK1 protein"}
{"concept_id": "C4326985", "aliases": [], "types": ["T044"], "canonical_name": "activation of JAK1 kinase activity"}
{"concept_id": "C4326986", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tyrosine phosphorylation of Stat7 protein"}
{"concept_id": "C4326987", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tyrosine phosphorylation of Stat6 protein"}
{"concept_id": "C4326988", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tyrosine phosphorylation of Stat5 protein"}
{"concept_id": "C4326989", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tyrosine phosphorylation of Stat4 protein"}
{"concept_id": "C4326990", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tyrosine phosphorylation of Stat3 protein"}
{"concept_id": "C4326991", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tyrosine phosphorylation of Stat2 protein"}
{"concept_id": "C4326992", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tyrosine phosphorylation of Stat1 protein"}
{"concept_id": "C4326993", "aliases": ["down-regulation of tyrosine phosphorylation of Stat7 protein", "downregulation of tyrosine phosphorylation of Stat7 protein"], "types": ["T044"], "canonical_name": "down regulation of tyrosine phosphorylation of Stat7 protein"}
{"concept_id": "C4326994", "aliases": ["down-regulation of tyrosine phosphorylation of Stat6 protein", "downregulation of tyrosine phosphorylation of Stat6 protein"], "types": ["T044"], "canonical_name": "down regulation of tyrosine phosphorylation of Stat6 protein"}
{"concept_id": "C4326995", "aliases": ["down-regulation of tyrosine phosphorylation of Stat5 protein", "downregulation of tyrosine phosphorylation of Stat5 protein"], "types": ["T044"], "canonical_name": "down regulation of tyrosine phosphorylation of Stat5 protein"}
{"concept_id": "C4326996", "aliases": ["down-regulation of tyrosine phosphorylation of Stat4 protein", "downregulation of tyrosine phosphorylation of Stat4 protein"], "types": ["T044"], "canonical_name": "down regulation of tyrosine phosphorylation of Stat4 protein"}
{"concept_id": "C4326997", "aliases": ["downregulation of tyrosine phosphorylation of Stat3 protein", "down-regulation of tyrosine phosphorylation of Stat3 protein"], "types": ["T044"], "canonical_name": "down regulation of tyrosine phosphorylation of Stat3 protein"}
{"concept_id": "C4326998", "aliases": ["down-regulation of tyrosine phosphorylation of Stat2 protein", "downregulation of tyrosine phosphorylation of Stat2 protein"], "types": ["T044"], "canonical_name": "down regulation of tyrosine phosphorylation of Stat2 protein"}
{"concept_id": "C4326999", "aliases": ["down-regulation of tyrosine phosphorylation of Stat1 protein", "downregulation of tyrosine phosphorylation of Stat1 protein"], "types": ["T044"], "canonical_name": "down regulation of tyrosine phosphorylation of Stat1 protein"}
{"concept_id": "C4327000", "aliases": ["upregulation of tyrosine phosphorylation of Stat7 protein", "up-regulation of tyrosine phosphorylation of Stat7 protein"], "types": ["T044"], "canonical_name": "up regulation of tyrosine phosphorylation of Stat7 protein"}
{"concept_id": "C4327001", "aliases": ["up-regulation of tyrosine phosphorylation of Stat6 protein", "upregulation of tyrosine phosphorylation of Stat6 protein"], "types": ["T044"], "canonical_name": "up regulation of tyrosine phosphorylation of Stat6 protein"}
{"concept_id": "C4327002", "aliases": ["up-regulation of tyrosine phosphorylation of Stat5 protein", "upregulation of tyrosine phosphorylation of Stat5 protein"], "types": ["T044"], "canonical_name": "up regulation of tyrosine phosphorylation of Stat5 protein"}
{"concept_id": "C4327003", "aliases": ["up-regulation of tyrosine phosphorylation of Stat4 protein", "upregulation of tyrosine phosphorylation of Stat4 protein"], "types": ["T044"], "canonical_name": "up regulation of tyrosine phosphorylation of Stat4 protein"}
{"concept_id": "C4327004", "aliases": ["up-regulation of tyrosine phosphorylation of Stat3 protein", "upregulation of tyrosine phosphorylation of Stat3 protein"], "types": ["T044"], "canonical_name": "up regulation of tyrosine phosphorylation of Stat3 protein"}
{"concept_id": "C4327005", "aliases": ["upregulation of tyrosine phosphorylation of Stat2 protein", "up-regulation of tyrosine phosphorylation of Stat2 protein"], "types": ["T044"], "canonical_name": "up regulation of tyrosine phosphorylation of Stat2 protein"}
{"concept_id": "C4327006", "aliases": ["up-regulation of tyrosine phosphorylation of Stat1 protein", "upregulation of tyrosine phosphorylation of Stat1 protein"], "types": ["T044"], "canonical_name": "up regulation of tyrosine phosphorylation of Stat1 protein"}
{"concept_id": "C4327007", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of Stat7 protein"}
{"concept_id": "C4327008", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of Stat6 protein"}
{"concept_id": "C4327009", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of Stat5 protein"}
{"concept_id": "C4327010", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of Stat4 protein"}
{"concept_id": "C4327011", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of Stat3 protein"}
{"concept_id": "C4327012", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of Stat2 protein"}
{"concept_id": "C4327013", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tyrosine phosphorylation of Stat1 protein"}
{"concept_id": "C4327014", "aliases": [], "types": ["T044"], "canonical_name": "protein deglycation of methylglyoxal-glycated protein"}
{"concept_id": "C4327015", "aliases": [], "types": ["T044"], "canonical_name": "protein deglycation of glyoxal-glycated protein"}
{"concept_id": "C4327016", "aliases": [], "types": ["T044"], "canonical_name": "deglycation of N-acetyllysine"}
{"concept_id": "C4327017", "aliases": [], "types": ["T044"], "canonical_name": "deglycation of N-acetylcysteine"}
{"concept_id": "C4327018", "aliases": [], "types": ["T044"], "canonical_name": "glycated protein repair"}
{"concept_id": "C4327019", "aliases": [], "types": ["T044"], "canonical_name": "protein deglycating enzyme"}
{"concept_id": "C4327021", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host protein localisation to phagosome"}
{"concept_id": "C4327022", "aliases": [], "types": ["T026"], "canonical_name": "connecting cilium"}
{"concept_id": "C4327023", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)"}
{"concept_id": "C4327024", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming)"}
{"concept_id": "C4327025", "aliases": [], "types": ["T044"], "canonical_name": "type III protein arginine methyltransferase activity"}
{"concept_id": "C4327026", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega-methyl-L-arginine-forming)"}
{"concept_id": "C4327027", "aliases": ["up-regulation of serine phosphorylation of STAT3 protein", "upregulation of serine phosphorylation of STAT3 protein"], "types": ["T044"], "canonical_name": "up regulation of serine phosphorylation of STAT3 protein"}
{"concept_id": "C4327028", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of serine phosphorylation of STAT3 protein"}
{"concept_id": "C4327029", "aliases": [], "types": ["T044"], "canonical_name": "activation of serine phosphorylation of STAT3 protein"}
{"concept_id": "C4327030", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of serine phosphorylation of STAT3 protein"}
{"concept_id": "C4327031", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of serine phosphorylation of STAT3 protein"}
{"concept_id": "C4327032", "aliases": ["downregulation of serine phosphorylation of STAT3 protein", "down-regulation of serine phosphorylation of STAT3 protein"], "types": ["T044"], "canonical_name": "down regulation of serine phosphorylation of STAT3 protein"}
{"concept_id": "C4327033", "aliases": ["up-regulation of protein phosphatase type 2B activity", "upregulation of protein phosphatase type 2B activity"], "types": ["T044"], "canonical_name": "up regulation of protein phosphatase type 2B activity"}
{"concept_id": "C4327034", "aliases": ["up-regulation of protein phosphatase type 2A activity", "upregulation of protein phosphatase type 2A activity"], "types": ["T044"], "canonical_name": "up regulation of protein phosphatase type 2A activity"}
{"concept_id": "C4327035", "aliases": [], "types": ["T044"], "canonical_name": "up regulation of protein phosphatase 3 activity"}
{"concept_id": "C4327036", "aliases": [], "types": ["T044"], "canonical_name": "up regulation of calcineurin activity"}
{"concept_id": "C4327037", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of protein phosphatase 2 activity"}
{"concept_id": "C4327038", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of protein phosphatase type 2B activity"}
{"concept_id": "C4327039", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of protein phosphatase type 2A activity"}
{"concept_id": "C4327040", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of protein phosphatase 3 activity"}
{"concept_id": "C4327041", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of protein phosphatase 2 activity"}
{"concept_id": "C4327042", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of calcineurin activity"}
{"concept_id": "C4327043", "aliases": [], "types": ["T044"], "canonical_name": "calcineurin activation"}
{"concept_id": "C4327044", "aliases": [], "types": ["T044"], "canonical_name": "activation of protein phosphatase 3 activity"}
{"concept_id": "C4327045", "aliases": [], "types": ["T044"], "canonical_name": "activation of calcineurin activity"}
{"concept_id": "C4327046", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein phosphatase type 2B activity"}
{"concept_id": "C4327047", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein phosphatase type 2A activity"}
{"concept_id": "C4327048", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein phosphatase 2 activity"}
{"concept_id": "C4327049", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of calcineurin activity"}
{"concept_id": "C4327050", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein phosphatase 3 activity"}
{"concept_id": "C4327051", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of protein phosphatase 2 activity"}
{"concept_id": "C4327052", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of calcineurin activity"}
{"concept_id": "C4327053", "aliases": ["down-regulation of protein phosphatase type 2B activity", "downregulation of protein phosphatase type 2B activity"], "types": ["T044"], "canonical_name": "down regulation of protein phosphatase type 2B activity"}
{"concept_id": "C4327054", "aliases": ["down-regulation of protein phosphatase type 2A activity", "downregulation of protein phosphatase type 2A activity"], "types": ["T044"], "canonical_name": "down regulation of protein phosphatase type 2A activity"}
{"concept_id": "C4327055", "aliases": ["downregulation of protein phosphatase 3 activity"], "types": ["T044"], "canonical_name": "down regulation of protein phosphatase 3 activity"}
{"concept_id": "C4327056", "aliases": ["downregulation of calcineurin activity"], "types": ["T044"], "canonical_name": "down regulation of calcineurin activity"}
{"concept_id": "C4327057", "aliases": ["replication fork processing at ribosomal DNA locus"], "types": ["T045"], "canonical_name": "replication fork processing at rDNA locus"}
{"concept_id": "C4327058", "aliases": [], "types": ["T045"], "canonical_name": "recovery from replication fork stalling at rDNA locus"}
{"concept_id": "C4327059", "aliases": [], "types": ["T045"], "canonical_name": "recovery from replication fork arrest at rDNA locus"}
{"concept_id": "C4327060", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation"}
{"concept_id": "C4327061", "aliases": ["cyclin degradation"], "types": ["T044"], "canonical_name": "degradation of cyclin"}
{"concept_id": "C4327062", "aliases": ["cyclin catabolic process"], "types": ["T044"], "canonical_name": "cyclin catabolism"}
{"concept_id": "C4327063", "aliases": [], "types": ["T044"], "canonical_name": "cyclin breakdown"}
{"concept_id": "C4327068", "aliases": [], "types": ["T043"], "canonical_name": "autophagic membrane degradation"}
{"concept_id": "C4327069", "aliases": [], "types": ["T043"], "canonical_name": "autophagic membrane catabolism"}
{"concept_id": "C4327070", "aliases": [], "types": ["T044"], "canonical_name": "5-hydroxytryptamine-gated receptor-channel"}
{"concept_id": "C4327071", "aliases": [], "types": ["T026"], "canonical_name": "Salmonella-containing vacuole"}
{"concept_id": "C4327072", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase type 2B regulator activity"}
{"concept_id": "C4327073", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 3, intrinsic regulator activity"}
{"concept_id": "C4327074", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase 3 regulator activity"}
{"concept_id": "C4327075", "aliases": [], "types": ["T044"], "canonical_name": "calcineurin, intrinsic regulator activity"}
{"concept_id": "C4327076", "aliases": [], "types": ["T044"], "canonical_name": "calcineurin regulator activity"}
{"concept_id": "C4327077", "aliases": ["up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter", "up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C4327078", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C4327079", "aliases": ["up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter", "up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C4327080", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C4327081", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C4327082", "aliases": [], "types": ["T045"], "canonical_name": "activation of meiosis by positive regulation of transcription from RNA polymerase II promoter"}
{"concept_id": "C4327083", "aliases": [], "types": ["T043"], "canonical_name": "programmed cell death involved in development"}
{"concept_id": "C4327084", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of activation of JAK2 protein"}
{"concept_id": "C4327085", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of activation of JAK2 kinase activity"}
{"concept_id": "C4327086", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of activation of JAK1 protein"}
{"concept_id": "C4327087", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of activation of JAK1 kinase activity"}
{"concept_id": "C4327088", "aliases": [], "types": ["T044"], "canonical_name": "regulation of activation of JAK2 protein"}
{"concept_id": "C4327089", "aliases": [], "types": ["T044"], "canonical_name": "regulation of activation of JAK2 kinase activity"}
{"concept_id": "C4327090", "aliases": [], "types": ["T044"], "canonical_name": "regulation of activation of JAK1 protein"}
{"concept_id": "C4327091", "aliases": [], "types": ["T044"], "canonical_name": "regulation of activation of JAK1 kinase activity"}
{"concept_id": "C4327092", "aliases": [], "types": ["T043"], "canonical_name": "chemoreception"}
{"concept_id": "C4327093", "aliases": [], "types": ["T043"], "canonical_name": "male nuclear division"}
{"concept_id": "C4327094", "aliases": [], "types": ["T043"], "canonical_name": "ciliary basal body duplication"}
{"concept_id": "C4327095", "aliases": [], "types": ["T043"], "canonical_name": "centrosome organization and biogenesis"}
{"concept_id": "C4327096", "aliases": [], "types": ["T026"], "canonical_name": "mother centriole"}
{"concept_id": "C4327097", "aliases": [], "types": ["T026"], "canonical_name": "daughter centriole"}
{"concept_id": "C4327098", "aliases": ["laminin-321 complex location"], "types": ["T026"], "canonical_name": "laminin-321 complex"}
{"concept_id": "C4327099", "aliases": ["laminin-332 complex location"], "types": ["T026"], "canonical_name": "laminin-332 complex"}
{"concept_id": "C4327100", "aliases": [], "types": ["T043"], "canonical_name": "cilium movement involved in fluid flow"}
{"concept_id": "C4327101", "aliases": [], "types": ["T042"], "canonical_name": "regulation of vasodilation by neuronal norepinephrine"}
{"concept_id": "C4327102", "aliases": [], "types": ["T042"], "canonical_name": "regulation of vasodilation by neuronal noradrenaline"}
{"concept_id": "C4327103", "aliases": [], "types": ["T042"], "canonical_name": "regulation of vasodilation by circulating norepinephrine"}
{"concept_id": "C4327104", "aliases": [], "types": ["T042"], "canonical_name": "regulation of vasodilation by circulating noradrenaline"}
{"concept_id": "C4327105", "aliases": [], "types": ["T042"], "canonical_name": "regulation of vasodilation by neuronal epinephrine"}
{"concept_id": "C4327106", "aliases": [], "types": ["T042"], "canonical_name": "regulation of vasodilation by neuronal adrenaline"}
{"concept_id": "C4327107", "aliases": [], "types": ["T042"], "canonical_name": "regulation of vasodilation by circulating epinephrine"}
{"concept_id": "C4327108", "aliases": [], "types": ["T042"], "canonical_name": "regulation of vasodilation by circulating adrenaline"}
{"concept_id": "C4327109", "aliases": [], "types": ["T044"], "canonical_name": "phospho-AI-2 isomerase activity"}
{"concept_id": "C4327110", "aliases": ["mitotic nuclear division"], "types": ["T043"], "definition": "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. [ISBN:0198547684]", "canonical_name": "mitosis"}
{"concept_id": "C4327112", "aliases": ["mitotic spindle astral microtubule tip"], "types": ["T026"], "canonical_name": "mitotic spindle astral microtubule end", "definition": "Any microtubule end that is part of a mitotic spindle astral microtubule. [GO_REF:0000064, GOC:TermGenie, PMID:11007487]"}
{"concept_id": "C4327119", "aliases": ["positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "positive regulation of EGF receptor signalling pathway involved in heart process", "up-regulation of ERBB1 signaling pathway involved in heart process", "up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "up regulation of ERBB1 signaling pathway involved in heart process", "positive regulation of ERBB1 signaling pathway involved in heart process", "up-regulation of EGFR signaling pathway involved in heart process", "upregulation of EGF receptor signaling pathway involved in heart process", "up-regulation of EGF receptor signaling pathway involved in heart process", "positive regulation of epidermal growth factor receptor signalling pathway involved in heart process", "positive regulation of EGFR signaling pathway involved in heart process", "up regulation of EGF receptor signalling pathway involved in heart process", "up-regulation of epidermal growth factor receptor signalling pathway involved in heart process", "upregulation of EGF receptor signalling pathway involved in heart process", "up regulation of epidermal growth factor receptor signaling pathway involved in heart process", "up regulation of epidermal growth factor receptor signalling pathway involved in heart process", "up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "upregulation of ERBB1 signaling pathway involved in heart process", "up-regulation of EGF receptor signalling pathway involved in heart process", "up regulation of EGFR signaling pathway involved in heart process", "upregulation of epidermal growth factor receptor signaling pathway involved in heart process", "upregulation of epidermal growth factor receptor signalling pathway involved in heart process", "upregulation of EGFR signaling pathway involved in heart process", "upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "up-regulation of epidermal growth factor receptor signaling pathway involved in heart process", "positive regulation of EGF receptor signaling pathway involved in heart process", "up regulation of EGF receptor signaling pathway involved in heart process"], "types": ["T044"], "canonical_name": "positive regulation of epidermal growth factor receptor signaling pathway involved in heart process", "definition": "OBSOLETE. Any positive regulation of epidermal growth factor receptor signaling pathway that is involved in heart process. [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]"}
{"concept_id": "C4327120", "aliases": ["down-regulation of ERBB1 signaling pathway involved in heart process", "down regulation of EGF receptor signalling pathway involved in heart process", "downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "downregulation of EGF receptor signalling pathway involved in heart process", "negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "down-regulation of epidermal growth factor receptor signaling pathway involved in heart process", "negative regulation of epidermal growth factor receptor signalling pathway involved in heart process", "negative regulation of EGFR signaling pathway involved in heart process", "negative regulation of EGF receptor signalling pathway involved in heart process", "downregulation of epidermal growth factor receptor signalling pathway involved in heart process", "down regulation of epidermal growth factor receptor signalling pathway involved in heart process", "down-regulation of EGF receptor signaling pathway involved in heart process", "downregulation of EGFR signaling pathway involved in heart process", "down regulation of epidermal growth factor receptor signaling pathway involved in heart process", "downregulation of EGF receptor signaling pathway involved in heart process", "negative regulation of EGF receptor signaling pathway involved in heart process", "negative regulation of ERBB1 signaling pathway involved in heart process", "down-regulation of EGFR signaling pathway involved in heart process", "down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "downregulation of epidermal growth factor receptor signaling pathway involved in heart process", "down-regulation of EGF receptor signalling pathway involved in heart process", "down regulation of EGFR signaling pathway involved in heart process", "down-regulation of epidermal growth factor receptor signalling pathway involved in heart process", "downregulation of ERBB1 signaling pathway involved in heart process", "down regulation of ERBB1 signaling pathway involved in heart process", "down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "down regulation of EGF receptor signaling pathway involved in heart process"], "types": ["T044"], "canonical_name": "negative regulation of epidermal growth factor receptor signaling pathway involved in heart process", "definition": "OBSOLETE. Any negative regulation of epidermal growth factor receptor signaling pathway that is involved in heart process. [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]"}
{"concept_id": "C4327121", "aliases": ["regulation of epidermal growth factor receptor signalling pathway involved in heart process", "regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "regulation of EGFR signaling pathway involved in heart process", "regulation of EGF receptor signalling pathway involved in heart process", "regulation of ERBB1 signaling pathway involved in heart process", "regulation of EGF receptor signaling pathway involved in heart process"], "types": ["T044"], "canonical_name": "regulation of epidermal growth factor receptor signaling pathway involved in heart process", "definition": "OBSOLETE. Any regulation of epidermal growth factor receptor signaling pathway that is involved in heart process. [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]"}
{"concept_id": "C4327126", "aliases": ["neurotransmitter receptor complex location"], "types": ["T026"], "canonical_name": "neurotransmitter receptor complex", "definition": "Any protein complex that is capable of functioning as a neurotransmitter receptor. [GOC:dos]"}
{"concept_id": "C4327127", "aliases": ["DNA methyltransferase complex location"], "types": ["T026"], "canonical_name": "DNA methyltransferase complex", "definition": "A protein complex that possesses DNA methyltransferase activity. [PMID:20939822, PMID:24947342]"}
{"concept_id": "C4327128", "aliases": ["multimerin complex location"], "types": ["T026"], "canonical_name": "multimerin complex", "definition": "Glycoprotein complex of the C1q/TNF superfamily involved in cell adhesion. A homotrimer that will combine to form supramolecular Multimerin structures. [GOC:bhm, PMID:9454761]"}
{"concept_id": "C4327129", "aliases": ["EMILIN complex location"], "types": ["T026"], "canonical_name": "EMILIN complex", "definition": "Glycoprotein complex of the C1q/TNF superfamily found in the extracellular matrix (ECM) where it is an important component of the elastic fiber system. A homotrimer that will combine to form supramolecular EMILIN structures. [GOC:bhm, PMID:10821830]"}
{"concept_id": "C4327130", "aliases": ["actin cytoskeleton-regulatory complex location"], "types": ["T026"], "canonical_name": "actin cytoskeleton-regulatory complex", "definition": "A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat. [GOC:bhm, PMID:10594004, PMID:11739778]"}
{"concept_id": "C4327131", "aliases": ["NPHP complex location", "NPHP module"], "types": ["T026"], "canonical_name": "NPHP complex", "definition": "A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways. [GOC:cilia, PMID:18337471, PMID:21422230, PMID:21498478, PMID:21555462, PMID:25150219]"}
{"concept_id": "C4327132", "aliases": ["ESCRT IV complex location", "ESCRT-IV"], "types": ["T026"], "canonical_name": "ESCRT IV complex", "definition": "An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1. [GOC:bhm, GOC:ha, PMID:20653365, PMID:20696398, PMID:21925211, PMID:24456136, PMID:25164817, PMID:26775243]"}
{"concept_id": "C4327133", "aliases": ["protein-cysteine S-palmitoyltransferase complex location"], "types": ["T026"], "canonical_name": "protein-cysteine S-palmitoyltransferase complex", "definition": "A protein complex which is capable of protein-cysteine S-palmitoyltransferase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20851885]"}
{"concept_id": "C4327134", "aliases": ["ferroxidase complex location"], "types": ["T026"], "canonical_name": "ferroxidase complex", "definition": "A protein complex which is capable of ferroxidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16522632]"}
{"concept_id": "C4327135", "aliases": ["Ras guanyl-nucleotide exchange factor complex location"], "types": ["T026"], "canonical_name": "Ras guanyl-nucleotide exchange factor complex", "definition": "A protein complex which is capable of Ras guanyl-nucleotide exchange factor activity. [GO_REF:0000088, GOC:rjd, GOC:TermGenie, PMID:20493808]"}
{"concept_id": "C4327136", "aliases": ["IL-10-receptor complex", "interleukin-10 receptor complex location", "IL10 receptor complex location", "IL-10-receptor complex location", "IL-10 receptor complex", "interleukin-10-receptor complex", "IL10 receptor complex", "interleukin-10-receptor complex location", "IL-10 receptor complex location"], "types": ["T026"], "canonical_name": "interleukin-10 receptor complex", "definition": "A protein complex that binds interleukin-10 (IL-10) and that consists of, at a minimum, a dimeric interleukin, an alpha and a beta chain as well as optional additional kinase subunits. The alpha chain binds IL-10 with high affinity and subsequently binds the common beta receptor chain that forms part of multiple interleukin receptors. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16982608]"}
{"concept_id": "C4327137", "aliases": ["interleukin-15 receptor complex location", "IL15-receptor complex", "IL15 receptor complex location", "IL-15-receptor complex location", "IL-15-receptor complex", "interleukin-15-receptor complex location", "IL15-receptor complex location", "IL-15 receptor complex location", "IL15 receptor complex", "IL-15 receptor complex", "interleukin-15-receptor complex"], "types": ["T026"], "canonical_name": "interleukin-15 receptor complex", "definition": "A protein complex that binds interleukin-15 (IL-15) and that consists of, at a minimum, an interleukin, an alpha, beta and gamma chain as well as optional additional kinase subunits. The alpha chain is unique to binds IL-15 while it shares the beta chain with the IL-2 receptor and the cytokine receptor common gamma chain with multiple interleukin receptors. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23104097]"}
{"concept_id": "C4327138", "aliases": ["IL7-receptor complex", "IL7-receptor complex location", "IL-7 receptor complex location", "IL-7-receptor complex", "IL7 receptor complex location", "interleukin-7 receptor complex location", "IL-7 receptor complex", "IL-7-receptor complex location", "IL7 receptor complex"], "types": ["T026"], "canonical_name": "interleukin-7 receptor complex", "definition": "A protein complex that binds interleukin-7 (IL-7) and that consists of, at a minimum, an interleukin, an alpha and a gamma chain as well as optional additional kinase subunits. The alpha chain binds IL-7 with high affinity and subsequently binds the cytokine receptor common gamma chain that forms part of multiple interleukin receptors. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:19141282]"}
{"concept_id": "C4327139", "aliases": ["beta-N-acetylhexosaminidase complex location"], "types": ["T026"], "canonical_name": "beta-N-acetylhexosaminidase complex", "definition": "A protein complex which is capable of beta-N-acetylhexosaminidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:6458607]"}
{"concept_id": "C4327140", "aliases": ["serine-type endopeptidase complex location"], "types": ["T026"], "canonical_name": "serine-type endopeptidase complex", "definition": "A protein complex which is capable of serine-type endopeptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]"}
{"concept_id": "C4327141", "aliases": ["endopeptidase complex location"], "types": ["T026"], "canonical_name": "endopeptidase complex", "definition": "A protein complex which is capable of endopeptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]"}
{"concept_id": "C4327142", "aliases": ["peptidase complex location", "protease complex", "protease complex location"], "types": ["T026"], "canonical_name": "peptidase complex", "definition": "A protein complex which is capable of peptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]"}
{"concept_id": "C4327143", "aliases": ["GTPase complex location"], "types": ["T026"], "canonical_name": "GTPase complex", "definition": "A protein complex which is capable of GTPase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006]"}
{"concept_id": "C4327144", "aliases": ["exoribonuclease complex location"], "types": ["T026"], "canonical_name": "exoribonuclease complex", "definition": "A protein complex which is capable of exoribonuclease activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17174896]"}
{"concept_id": "C4327145", "aliases": ["endonuclease complex location"], "types": ["T026"], "canonical_name": "endonuclease complex", "definition": "A protein complex which is capable of endonuclease activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]"}
{"concept_id": "C4327146", "aliases": ["endodeoxyribonuclease complex location"], "types": ["T026"], "canonical_name": "endodeoxyribonuclease complex", "definition": "A protein complex which is capable of endodeoxyribonuclease activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]"}
{"concept_id": "C4327147", "aliases": ["serine-type peptidase complex location"], "types": ["T026"], "canonical_name": "serine-type peptidase complex", "definition": "A protein complex which is capable of serine-type peptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18640965]"}
{"concept_id": "C4327148", "aliases": ["KICSTOR complex location"], "types": ["T026"], "canonical_name": "KICSTOR complex", "definition": "A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2. [PMID:28199306]"}
{"concept_id": "C4327149", "aliases": ["toxin-antitoxin complex location"], "types": ["T026"], "canonical_name": "toxin-antitoxin complex", "definition": "A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon. [GOC:bhm, PMID:16109374, PMID:25093388]"}
{"concept_id": "C4327150", "aliases": ["Abeta complex", "beta-amyloid complex", "amyloid-beta complex location", "betaA complex location", "amyloid beta complex location", "Abeta complex location", "beta amyloid complex location", "betaA complex", "amyloid beta complex", "beta amyloid complex", "beta-amyloid complex location"], "types": ["T026"], "canonical_name": "amyloid-beta complex", "definition": "Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease. [GOC:bhm, PMID:18568035]"}
{"concept_id": "C4327151", "aliases": ["mCRD-poly(A)-bridging complex location", "major coding region determinant of instability-mediated mRNA stability complex location", "mCRD-poly(A)-bridging complex", "major coding region instability determinant-mediated mRNA stability complex", "major coding region instability determinant-poly(A)-bridging complex", "mCRD-mediated mRNA stability complex location", "major coding region instability determinant-poly(A)-bridging complex location", "major coding-region determinant of instability - poly(A) tail-bridging complex", "major coding region instability determinant-mediated mRNA stability complex location", "major coding-region determinant of instability - poly(A) tail-bridging complex location", "major coding region determinant of instability-mediated mRNA stability complex"], "types": ["T026"], "canonical_name": "mCRD-mediated mRNA stability complex", "definition": "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP. [GOC:bhm, PMID:11051545]"}
{"concept_id": "C4327152", "aliases": ["chaperone complex location"], "types": ["T026"], "canonical_name": "chaperone complex", "definition": "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. [GOC:bhm, PMID:21855797]"}
{"concept_id": "C4327153", "aliases": ["nucleolar exosome (RNase complex location)"], "types": ["T026"], "canonical_name": "nucleolar exosome (RNase complex)", "definition": "A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. [PMID:17174896, PMID:20531386, PMID:26726035]"}
{"concept_id": "C4327154", "aliases": ["mitochondrial iron-sulfur cluster assembly complex location"], "types": ["T026"], "canonical_name": "mitochondrial iron-sulfur cluster assembly complex", "definition": "A protein complex consisting of frataxin, cysteine desulfurase, an accessory protein and a Fe-S scaffold protein. In human these genes correspond to FXN, NFS1, ISD11 and ISCU respectively. This complex assembles Fe-S clusters onto the scaffolding protein using the substrates ferrous iron, electrons, and sulfur from l-cysteine. [PMID:27519411]"}
{"concept_id": "C4327155", "aliases": ["TGFbeta dimer", "TGF-beta complex", "TGFB dimer", "TGF-beta dimer", "TGFB complex", "TGFbeta complex location", "transforming growth factor beta complex location", "TGF-beta complex location", "TGFB complex location", "TGFbeta complex"], "types": ["T026"], "canonical_name": "transforming growth factor beta complex", "definition": "A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerisation and dissociation of the LAP. [GOC:bhm, PMID:22943793]"}
{"concept_id": "C4327156", "aliases": ["PAK family kinase-Sog2 complex location"], "types": ["T026"], "canonical_name": "PAK family kinase-Sog2 complex", "definition": "A protein kinase complex comprising a conserved PAK/GC/Ste20 family kinase, leucine rich repeat protein Sog2 family, which function as part of the cell shape network. [PMID:23462181]"}
{"concept_id": "C4327157", "aliases": ["supramolecular complex location"], "types": ["T026"], "canonical_name": "supramolecular complex", "definition": "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. [GOC:dos]"}
{"concept_id": "C4327158", "aliases": ["BORC complex location"], "types": ["T026"], "canonical_name": "BORC complex", "definition": "A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors. [GOC:dos, GOC:li, PMID:25898167]"}
{"concept_id": "C4327159", "aliases": ["ASC-1 complex location", "ASC-1 complex", "activating signal cointegrator 1 complex location"], "types": ["T026"], "canonical_name": "activating signal cointegrator 1 complex", "definition": "A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3. [PMID:12077347]"}
{"concept_id": "C4327160", "aliases": ["vesicle tethering complex location"], "types": ["T026"], "canonical_name": "vesicle tethering complex", "definition": "Any protein complex that plays a role in vesicle tethering. [GOC:dos, GOC:vw, PMID:27243008]"}
{"concept_id": "C4327161", "aliases": ["G-protein coupled serotonin receptor complex", "G-protein coupled serotonin receptor complex location", "G protein-coupled serotonin receptor complex location"], "types": ["T026"], "canonical_name": "G protein-coupled serotonin receptor complex", "definition": "A protein complex that is capable of G protein-coupled serotonin receptor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie]"}
{"concept_id": "C4327162", "aliases": ["tenascin complex location"], "types": ["T026"], "canonical_name": "tenascin complex", "definition": "A extracellular matrix complex involved in cell adhesion and cell migration. Typically homotrimeric or homohexameric. In mammals, four complexes exist: Tenascin-C, Tenascin-N (also known as Tenascin-W), Tenascin-X and Tenascin-R. [GOC:bhm, PMID:11731446, PMID:12845616, PMID:17909022, PMID:23658023]"}
{"concept_id": "C4327163", "aliases": ["Las1 complex location"], "types": ["T026"], "canonical_name": "Las1 complex", "definition": "A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448). [GOC:vw, PMID:26638174]"}
{"concept_id": "C4327164", "aliases": ["Wpl/Pds5 cohesin loading/unloading complex location"], "types": ["T026"], "canonical_name": "Wpl/Pds5 cohesin loading/unloading complex", "definition": "A eukaryotically conserved heterodimeric protein complex (comprising Wings apart-like protein and the Pds5 Armadillo repeat cohesin associated protein) involved in the loading and unloading of a cohesin complex onto DNA. [GOC:vw, PMID:26687354]"}
{"concept_id": "C4327165", "aliases": ["Mis4-Ssl3 cohesin loading complex", "Scc2-Scc4 cohesin loading complex location", "Mis4-Ssl3 cohesin loading complex location"], "types": ["T026"], "canonical_name": "Scc2-Scc4 cohesin loading complex", "definition": "A eukaryotically conserved heterodimeric protein complex (comprising adherin and the chromatid cohesion factor MAU2/Scc4/Ssl3) required for the loading of a cohesin, complex onto DNA. [GOC:vw, PMID:24291789]"}
{"concept_id": "C4327166", "aliases": ["retrograte transporter complex, Golgi to endoplasmic reticulum", "retrograte transporter complex location, Golgi to endoplasmic reticulum", "retrograte receptor complex, Golgi to ER", "retrograte receptor complex, Golgi to endoplasmic reticulum", "retrograte receptor complex location, Golgi to ER", "retrograte receptor complex location, Golgi to endoplasmic reticulum", "retrograte transporter complex location, Golgi to ER"], "types": ["T026"], "canonical_name": "retrograte transporter complex, Golgi to ER", "definition": "Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles. [GOC:bhm, PMID:16093310]"}
{"concept_id": "C4327167", "aliases": ["high-affinity iron exporter complex location", "high affinity iron exporter complex location", "high affinity iron exporter complex"], "types": ["T026"], "canonical_name": "high-affinity iron exporter complex", "definition": "A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment. [GOC:bhm, PMID:10608875, PMID:9413439]"}
{"concept_id": "C4327168", "aliases": ["CENP-T-W-S-X complex location"], "types": ["T026"], "canonical_name": "CENP-T-W-S-X complex", "definition": "A histone-variant containing protein complex which forms a centromere specific nucleosomal structure, involved in centromeric chromatin organization. [PMID:22304909, PMID:22304917]"}
{"concept_id": "C4327169", "aliases": ["basal TBC", "basal tubulobulbar complex location"], "types": ["T026"], "canonical_name": "basal tubulobulbar complex", "definition": "Actin-based structures involved in establishing the blood-testis barrier of the Sertoli cell. [PMID:20403871, PMID:22510523]"}
{"concept_id": "C4327170", "aliases": ["apical TBC", "apical tubulobulbar complex location"], "types": ["T026"], "canonical_name": "apical tubulobulbar complex", "definition": "Actin-based structures involved in establishing close contact between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell. [PMID:20403871, PMID:22510523]"}
{"concept_id": "C4327172", "aliases": ["laminin 3B32 complex", "laminin-5B complex location", "laminin 3B32 complex location"], "types": ["T026"], "canonical_name": "laminin-5B complex", "definition": "A laminin complex composed of alpha3B, beta3 and gamma2 polypeptide chains. [GOC:dph, PMID:15979864]"}
{"concept_id": "C4327173", "aliases": ["chromatin lock complex location"], "types": ["T026"], "canonical_name": "chromatin lock complex", "definition": "A chromatin silencing complex that binds and bridges separate nucleosomal histones resulting in heterochromatin assembly and chromatin looping. [GOC:bhm, GOC:dph, PMID:17540172]"}
{"concept_id": "C4327174", "aliases": ["Tapasin-ERp57 complex location"], "types": ["T026"], "canonical_name": "Tapasin-ERp57 complex", "definition": "Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role. [GOC:bhm, GOC:dph, Intact:EBI-11896237, Intact:EBI-9013963, PMID:17603487]"}
{"concept_id": "C4327175", "aliases": ["energy dependent nucleolar silencing complex", "eNoSc complex location", "energy dependent nucleolar silencing complex location"], "types": ["T026"], "canonical_name": "eNoSc complex", "definition": "A chromatin silencing complex that recruits histone-modifying enzymes and upregulates silencing of rDNA in response to glucose starvation. [GOC:BHM, Intact:EBI-11789632, Intact:EBI-11790279, PMID:18485871]"}
{"concept_id": "C4327176", "aliases": ["MKS module", "MKS complex location"], "types": ["T026"], "canonical_name": "MKS complex", "definition": "A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane. [GOC:cilia, GOC:sp, PMID:21422230, PMID:21565611, PMID:21725307, PMID:22179047, PMID:25869670, PMID:26595381, PMID:26982032]"}
{"concept_id": "C4327177", "aliases": ["nucleocytoplasmic transport complex location"], "types": ["T026"], "canonical_name": "nucleocytoplasmic transport complex", "definition": "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores. [GOC:mah]"}
{"concept_id": "C4327248", "aliases": ["up-regulation of formation of growth cone in injured axon", "up regulation of formation of growth cone in injured axon", "upregulation of formation of growth cone in injured axon"], "types": ["T043"], "canonical_name": "positive regulation of formation of growth cone in injured axon", "definition": "Any process that activates or increases the frequency, rate or extent of formation of growth cone in injured axon. [GO_REF:0000058, GOC:TermGenie, PMID:19737525]"}
{"concept_id": "C4327249", "aliases": [], "types": ["T026"], "canonical_name": "leading edge of lamellipodium", "definition": "That part of the lamellipodium which represents the distal part of the structure. [PMID:22339865]"}
{"concept_id": "C4327250", "aliases": ["intranuclear actin rod"], "types": ["T026"], "canonical_name": "intranuclear rod", "definition": "A macromolecular fiber consisting of actin and cofilin that is formed in the nucleus as a consequence of chemical or mechanical stress conditions. [PMID:28074884]"}
{"concept_id": "C4327251", "aliases": [], "types": ["T026"], "canonical_name": "podosome core", "definition": "The F-actin-rich core of an adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. [PMID:23158496]"}
{"concept_id": "C4327252", "aliases": [], "types": ["T040"], "canonical_name": "chimeric colonial development", "definition": "Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype. [PMID:18272966]"}
{"concept_id": "C4327253", "aliases": [], "types": ["T026"], "canonical_name": "integral component of neuronal dense core vesicle membrane", "definition": "The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4327254", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane oxysterol transfer activity"}
{"concept_id": "C4327255", "aliases": [], "types": ["T040"], "canonical_name": "aerial mycelium formation", "definition": "The process by which hyphae grow in an upward or outward direction from the surface of the substrate; from there, propagative spores develop in or on characteristic structures that are distinctive of some fungal and bacterial species. The species that form an aerial mycelium develop conidiophores at the ends of the aerial hyphae. [GOC:di, PMID:12832397]"}
{"concept_id": "C4327256", "aliases": [], "types": ["T044"], "canonical_name": "10-oxogeraniol oxidoreductase activity", "definition": "Catalysis of the reaction: (6E)-8-oxogeraniol + NADP <=> (6E)-8-oxogeranial + NADPH + H+. [GOC:pz, RHEA:32615]"}
{"concept_id": "C4327258", "aliases": [], "types": ["T044"], "canonical_name": "DNA recombinase disassembly", "definition": "The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases). [GOC:pg, PMID:19540122]"}
{"concept_id": "C4327259", "aliases": [], "types": ["T044"], "canonical_name": "tRNA demethylase activity", "definition": "Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule. [PMID:27745969]"}
{"concept_id": "C4327260", "aliases": [], "types": ["T045"], "canonical_name": "tRNA demethylation", "definition": "The removal of a methyl group from one or more residues within a tRNA molecule. [PMID:27745969]"}
{"concept_id": "C4327261", "aliases": [], "types": ["T043"], "canonical_name": "protein transport along microtubule to mitotic spindle pole body", "definition": "The directed movement of a protein along a microtubule to the mitotic spindle pole body, mediated by motor proteins. [PMID:25987607]"}
{"concept_id": "C4327262", "aliases": [], "types": ["T043"], "canonical_name": "establishment of protein localization to mitotic spindle pole body"}
{"concept_id": "C4327263", "aliases": [], "types": ["T043"], "canonical_name": "actin-dependent nuclear migration", "definition": "The process whereby the centrosome is held at the cell center while the nucleus moves to the cell rear by actin retrograde flow resulting in the position of the centrosome between the nucleus and the leading edge of the cell. [GOC:hjd, PMID:21173262]"}
{"concept_id": "C4327264", "aliases": ["TAR binding"], "types": ["T045"], "canonical_name": "trans-activation response element binding", "definition": "Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter. [GOC:bf, GOC:PARL, PMID:25116364, Wikipedia:Trans-activation_response_element_(TAR)]"}
{"concept_id": "C4327265", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of viral RNA-binding transcription factor activity", "definition": "A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor. [GOC:bf, GOC:PARL, PMID:25116364]"}
{"concept_id": "C4327266", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of RNA binding by virus", "definition": "A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA. [GOC:bf, GOC:PARL, PMID:25116364]"}
{"concept_id": "C4327268", "aliases": [], "types": ["T044"], "canonical_name": "ATP generation from poly-ADP-D-ribose", "definition": "The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. [PMID:27257257]"}
{"concept_id": "C4327269", "aliases": [], "types": ["T044"], "canonical_name": "cytosylglucuronate decarboxylase activity", "definition": "Catalysis of the reaction: cytosylglucuronic acid + H(+) = cytosylarabinopyranose + CO(2). [GOC:pr, GOC:tb, PMID:23874663]"}
{"concept_id": "C4327270", "aliases": [], "types": ["T043"], "canonical_name": "drug transport across blood-brain barrier"}
{"concept_id": "C4327271", "aliases": [], "types": ["T044"], "canonical_name": "drug transmembrane export"}
{"concept_id": "C4327272", "aliases": ["basophilic leucocyte homeostasis"], "types": ["T043"], "canonical_name": "basophil homeostasis", "definition": "The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. [PMID:10606160]"}
{"concept_id": "C4327273", "aliases": ["eosinocyte homeostasis", "eosinophilic leukocyte homeostasis", "eosinophilic leucocyte homeostasis", "eosinophilic granulocyte homeostasis"], "types": ["T043"], "canonical_name": "eosinophil homeostasis", "definition": "The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. [PMID:10606160]"}
{"concept_id": "C4327274", "aliases": [], "types": ["T043"], "canonical_name": "fibroblast chemotaxis", "definition": "The directed movement of a fibroblast guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph, PMID:8760137]"}
{"concept_id": "C4327275", "aliases": [], "types": ["T045"], "canonical_name": "G-rich single-stranded DNA binding", "definition": "Binding to G-rich, single-stranded DNA. [GOC:hjd, PMID:8493094]"}
{"concept_id": "C4327276", "aliases": [], "types": ["T043"], "canonical_name": "establishment of protein localization to meiotic spindle pole body"}
{"concept_id": "C4327277", "aliases": ["synaptic facilitation"], "types": ["T043"], "canonical_name": "short-term synaptic potentiation", "definition": "The process by which synaptic transmission, induced by the arrival of a spike (action potential) at a synapse, acts to increase the amount of neurotransmitter released in response to the arrival of subsequent spikes. This effect is seen when a train of closely space spikes arrives at a synapse with a low initial release probability. It occurs in a timeframe of tens to hundreds of milliseconds. [GOC:dos, GOC:sp, ISBN:9780071120005, PMID:11826273, PMID:26738595]"}
{"concept_id": "C4327281", "aliases": [], "types": ["T043"], "canonical_name": "glutamatergic neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron. [GO_REF:0000086, GOC:TermGenie, PMID:24030726]"}
{"concept_id": "C4327282", "aliases": ["up regulation of cellular response to alcohol", "upregulation of cellular response to alcohol", "up-regulation of cellular response to alcohol"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to alcohol", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to alcohol. [GO_REF:0000058, GOC:TermGenie, PMID:26434723]"}
{"concept_id": "C4327283", "aliases": ["downregulation of cellular response to alcohol", "down-regulation of cellular response to alcohol", "down regulation of cellular response to alcohol"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to alcohol", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alcohol. [GO_REF:0000058, GOC:TermGenie, PMID:26434723]"}
{"concept_id": "C4327284", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to alcohol", "definition": "Any process that modulates the frequency, rate or extent of cellular response to alcohol. [GO_REF:0000058, GOC:TermGenie, PMID:26434723]"}
{"concept_id": "C4327285", "aliases": ["upregulation of endothelial tube morphogenesis", "up-regulation of endothelial tube morphogenesis", "up regulation of endothelial tube morphogenesis"], "types": ["T042"], "canonical_name": "positive regulation of endothelial tube morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718]"}
{"concept_id": "C4327286", "aliases": ["down-regulation of endothelial tube morphogenesis", "down regulation of endothelial tube morphogenesis", "downregulation of endothelial tube morphogenesis"], "types": ["T042"], "canonical_name": "negative regulation of endothelial tube morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718]"}
{"concept_id": "C4327287", "aliases": ["up-regulation of lipid localization", "upregulation of lipid localization", "positive regulation of lipid localisation", "upregulation of lipid localisation", "up regulation of lipid localization", "up-regulation of lipid localisation", "up regulation of lipid localisation"], "types": ["T039"], "canonical_name": "positive regulation of lipid localization", "definition": "Any process that activates or increases the frequency, rate or extent of lipid localization. [GO_REF:0000058, GOC:TermGenie, PMID:17564681]"}
{"concept_id": "C4327288", "aliases": ["down-regulation of lipid localization", "negative regulation of lipid localisation", "down regulation of lipid localization", "downregulation of lipid localization", "down regulation of lipid localisation", "downregulation of lipid localisation", "down-regulation of lipid localisation"], "types": ["T039"], "canonical_name": "negative regulation of lipid localization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. [GO_REF:0000058, GOC:TermGenie, PMID:17564681]"}
{"concept_id": "C4327289", "aliases": ["regulation of lipid localisation"], "types": ["T039"], "canonical_name": "regulation of lipid localization", "definition": "Any process that modulates the frequency, rate or extent of lipid localization. [GO_REF:0000058, GOC:TermGenie, PMID:17564681]"}
{"concept_id": "C4327290", "aliases": ["DNA recombination in mitochondria"], "types": ["T045"], "canonical_name": "mitochondrion DNA recombination", "definition": "Any DNA recombination that takes place in mitochondrion. [GO_REF:0000062, GOC:TermGenie, PMID:8087883]"}
{"concept_id": "C4327291", "aliases": [], "types": ["T043"], "canonical_name": "monosaccharide transmembrane transport", "definition": "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. [GO_REF:0000069, GOC:TermGenie, GOC:vw]"}
{"concept_id": "C4327292", "aliases": ["down regulation of calcium ion import across plasma membrane", "down-regulation of calcium ion import across plasma membrane", "downregulation of calcium ion import across plasma membrane"], "types": ["T043"], "canonical_name": "negative regulation of calcium ion import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]"}
{"concept_id": "C4327293", "aliases": ["3',5'-cyclic GMP transmembrane-transporting ATPase activity", "ATPase-coupled 3',5'-cyclic GMP transmembrane transporter activity", "ATP-dependent 3',5'-cyclic GMP transmembrane transporter activity", "ATPase-coupled cGMP transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type 3',5'-cyclic GMP transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + 3',5'-cyclic GMP(in) = ADP + phosphate + 3',5'-cyclic GMP(out). [GO_REF:0000070, GOC:TermGenie, PMID:18310115]"}
{"concept_id": "C4327294", "aliases": ["up regulation of response to calcium ion", "up-regulation of response to calcium ion", "upregulation of response to calcium ion", "positive regulation of response to Ca2+ ion", "upregulation of response to Ca2+ ion", "up regulation of response to Ca2+ ion", "up-regulation of response to Ca2+ ion"], "types": ["T039"], "canonical_name": "positive regulation of response to calcium ion", "definition": "Any process that activates or increases the frequency, rate or extent of response to calcium ion. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397]"}
{"concept_id": "C4327295", "aliases": ["down regulation of response to Ca2+ ion", "down-regulation of response to calcium ion", "negative regulation of response to Ca2+ ion", "down regulation of response to calcium ion", "downregulation of response to calcium ion", "downregulation of response to Ca2+ ion", "down-regulation of response to Ca2+ ion"], "types": ["T039"], "canonical_name": "negative regulation of response to calcium ion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of response to calcium ion. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397]"}
{"concept_id": "C4327296", "aliases": ["regulation of response to Ca2+ ion"], "types": ["T039"], "canonical_name": "regulation of response to calcium ion", "definition": "Any process that modulates the frequency, rate or extent of response to calcium ion. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397]"}
{"concept_id": "C4327297", "aliases": ["downregulation of formation of growth cone in injured axon", "down regulation of formation of growth cone in injured axon", "down-regulation of formation of growth cone in injured axon"], "types": ["T043"], "canonical_name": "negative regulation of formation of growth cone in injured axon", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of formation of growth cone in injured axon. [GO_REF:0000058, GOC:TermGenie, PMID:19737525]"}
{"concept_id": "C4327298", "aliases": [], "types": ["T043"], "canonical_name": "regulation of formation of growth cone in injured axon", "definition": "Any process that modulates the frequency, rate or extent of formation of growth cone in injured axon. [GO_REF:0000058, GOC:TermGenie, PMID:19737525]"}
{"concept_id": "C4327299", "aliases": ["upregulation of gonadogenesis", "up regulation of gonadogenesis", "up-regulation of gonad development", "up regulation of gonad development", "up-regulation of gonadogenesis", "upregulation of gonad development", "positive regulation of gonadogenesis"], "types": ["T042"], "canonical_name": "positive regulation of gonad development", "definition": "Any process that activates or increases the frequency, rate or extent of gonad development. [GO_REF:0000058, GOC:TermGenie, PMID:15342467]"}
{"concept_id": "C4327300", "aliases": ["negative regulation of gonadogenesis", "down regulation of gonad development", "downregulation of gonadogenesis", "down regulation of gonadogenesis", "down-regulation of gonad development", "downregulation of gonad development", "down-regulation of gonadogenesis"], "types": ["T042"], "canonical_name": "negative regulation of gonad development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. [GO_REF:0000058, GOC:TermGenie, PMID:15342467]"}
{"concept_id": "C4327301", "aliases": ["regulation of gonadogenesis"], "types": ["T039"], "canonical_name": "regulation of gonad development", "definition": "Any process that modulates the frequency, rate or extent of gonad development. [GO_REF:0000058, GOC:TermGenie, PMID:15342467]"}
{"concept_id": "C4327302", "aliases": ["upregulation of germ cell proliferation", "up-regulation of germ cell proliferation", "up regulation of germ cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of germ cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of germ cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:15342467]"}
{"concept_id": "C4327303", "aliases": ["down regulation of germ cell proliferation", "downregulation of germ cell proliferation", "down-regulation of germ cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of germ cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:15342467]"}
{"concept_id": "C4327304", "aliases": [], "types": ["T043"], "canonical_name": "regulation of germ cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of germ cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:15342467]"}
{"concept_id": "C4327305", "aliases": ["up-regulation of cell fate determination", "up regulation of cell fate determination", "upregulation of cell fate determination"], "types": ["T043"], "canonical_name": "positive regulation of cell fate determination", "definition": "Any process that activates or increases the frequency, rate or extent of cell fate determination. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578]"}
{"concept_id": "C4327306", "aliases": ["down-regulation of cell fate determination", "down regulation of cell fate determination", "downregulation of cell fate determination"], "types": ["T043"], "canonical_name": "negative regulation of cell fate determination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578]"}
{"concept_id": "C4327307", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell fate determination", "definition": "Any process that modulates the frequency, rate or extent of cell fate determination. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578]"}
{"concept_id": "C4327308", "aliases": ["upregulation of VSMC differentiation involved in phenotypic switching", "up-regulation of VSMC differentiation involved in phenotypic switching", "up regulation of vascular smooth muscle cell differentiation involved in phenotypic switching", "upregulation of vascular smooth muscle cell differentiation involved in phenotypic switching", "up regulation of VSMC differentiation involved in phenotypic switching", "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching", "positive regulation of VSMC differentiation involved in phenotypic switching", "upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching", "up-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching", "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching", "up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching"], "types": ["T043"], "canonical_name": "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching", "definition": "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]"}
{"concept_id": "C4327309", "aliases": ["downregulation of vascular smooth muscle cell differentiation involved in phenotypic switching", "down regulation of VSMC differentiation involved in phenotypic switching", "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching", "down regulation of vascular smooth muscle cell differentiation involved in phenotypic switching", "down-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching", "downregulation of VSMC differentiation involved in phenotypic switching", "downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching", "negative regulation of VSMC differentiation involved in phenotypic switching", "down-regulation of VSMC differentiation involved in phenotypic switching", "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching", "down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching"], "types": ["T043"], "canonical_name": "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]"}
{"concept_id": "C4327310", "aliases": ["regulation of vascular smooth muscle cell differentiation involved in phenotypic switching", "regulation of VSMC differentiation involved in phenotypic switching"], "types": ["T043"], "canonical_name": "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching", "definition": "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]"}
{"concept_id": "C4327317", "aliases": ["upregulation of acetylcholine anabolism", "positive regulation of acetylcholine synthesis", "up-regulation of acetylcholine synthesis", "positive regulation of acetylcholine biosynthesis", "up regulation of acetylcholine synthesis", "upregulation of acetylcholine synthesis", "positive regulation of acetylcholine formation", "up-regulation of acetylcholine biosynthetic process", "positive regulation of acetylcholine anabolism", "up-regulation of acetylcholine biosynthesis", "up regulation of acetylcholine formation", "upregulation of acetylcholine formation", "up-regulation of acetylcholine formation", "up-regulation of acetylcholine anabolism", "upregulation of acetylcholine biosynthetic process", "up regulation of acetylcholine anabolism", "upregulation of acetylcholine biosynthesis", "up regulation of acetylcholine biosynthesis", "up regulation of acetylcholine biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of acetylcholine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]"}
{"concept_id": "C4327318", "aliases": ["down-regulation of acetylcholine formation", "downregulation of acetylcholine synthesis", "down-regulation of acetylcholine synthesis", "downregulation of acetylcholine biosynthesis", "negative regulation of acetylcholine synthesis", "down-regulation of acetylcholine biosynthesis", "downregulation of acetylcholine formation", "down regulation of acetylcholine biosynthesis", "downregulation of acetylcholine anabolism", "down regulation of acetylcholine anabolism", "negative regulation of acetylcholine formation", "down regulation of acetylcholine formation", "negative regulation of acetylcholine anabolism", "down-regulation of acetylcholine anabolism", "down regulation of acetylcholine synthesis", "down-regulation of acetylcholine biosynthetic process", "down regulation of acetylcholine biosynthetic process", "negative regulation of acetylcholine biosynthesis", "downregulation of acetylcholine biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of acetylcholine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]"}
{"concept_id": "C4327319", "aliases": ["regulation of acetylcholine synthesis", "regulation of acetylcholine formation", "regulation of acetylcholine anabolism", "regulation of acetylcholine biosynthesis"], "types": ["T044"], "canonical_name": "regulation of acetylcholine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]"}
{"concept_id": "C4327320", "aliases": ["up-regulation of CoA-transferase activity", "upregulation of CoA-transferase activity", "up regulation of CoA-transferase activity"], "types": ["T044"], "canonical_name": "positive regulation of CoA-transferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of CoA-transferase activity. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]"}
{"concept_id": "C4327321", "aliases": ["down-regulation of CoA-transferase activity", "downregulation of CoA-transferase activity", "down regulation of CoA-transferase activity"], "types": ["T044"], "canonical_name": "negative regulation of CoA-transferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CoA-transferase activity. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]"}
{"concept_id": "C4327322", "aliases": [], "types": ["T044"], "canonical_name": "regulation of CoA-transferase activity", "definition": "Any process that modulates the frequency, rate or extent of CoA-transferase activity. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]"}
{"concept_id": "C4327323", "aliases": ["up-regulation of cell differentiation involved in phenotypic switching", "up regulation of cell differentiation involved in phenotypic switching", "upregulation of cell differentiation involved in phenotypic switching"], "types": ["T043"], "canonical_name": "positive regulation of cell differentiation involved in phenotypic switching", "definition": "Any process that activates or increases the frequency, rate or extent of cell differentiation involved in phenotypic switching. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]"}
{"concept_id": "C4327324", "aliases": ["downregulation of cell differentiation involved in phenotypic switching", "down-regulation of cell differentiation involved in phenotypic switching", "down regulation of cell differentiation involved in phenotypic switching"], "types": ["T043"], "canonical_name": "negative regulation of cell differentiation involved in phenotypic switching", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation involved in phenotypic switching. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]"}
{"concept_id": "C4327325", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell differentiation involved in phenotypic switching", "definition": "Any process that modulates the frequency, rate or extent of cell differentiation involved in phenotypic switching. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]"}
{"concept_id": "C4327326", "aliases": ["upregulation of calcium ion export from cell", "upregulation of calcium ion efflux from cell", "up-regulation of calcium ion efflux from cell", "up regulation of calcium ion efflux from cell", "positive regulation of calcium ion efflux from cell", "up regulation of calcium ion export from cell", "up-regulation of calcium ion export from cell", "positive regulation of calcium ion export from cell"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion export across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of calcium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515]"}
{"concept_id": "C4327327", "aliases": ["negative regulation of calcium ion export from cell", "down regulation of calcium ion export from cell", "down regulation of calcium ion efflux from cell", "downregulation of calcium ion efflux from cell", "negative regulation of calcium ion efflux from cell", "down-regulation of calcium ion export from cell", "downregulation of calcium ion export from cell", "down-regulation of calcium ion efflux from cell"], "types": ["T043"], "canonical_name": "negative regulation of calcium ion export across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515]"}
{"concept_id": "C4327328", "aliases": ["regulation of calcium ion efflux from cell", "regulation of calcium ion export from cell"], "types": ["T043"], "canonical_name": "regulation of calcium ion export across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515]"}
{"concept_id": "C4327329", "aliases": ["up-regulation of dauer entry", "up-regulation of nematode entry into dormancy", "positive regulation of nematode entry into dormancy", "up regulation of dauer entry", "up regulation of nematode entry into dormancy", "upregulation of dauer entry", "upregulation of nematode entry into dormancy"], "types": ["T040"], "canonical_name": "positive regulation of dauer entry", "definition": "Any process that activates or increases the frequency, rate or extent of dauer entry. [GO_REF:0000058, GOC:TermGenie, PMID:21531333]"}
{"concept_id": "C4327330", "aliases": ["down-regulation of dauer entry", "negative regulation of nematode entry into dormancy", "downregulation of nematode entry into dormancy", "down regulation of nematode entry into dormancy", "downregulation of dauer entry", "down regulation of dauer entry", "down-regulation of nematode entry into dormancy"], "types": ["T040"], "canonical_name": "negative regulation of dauer entry", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dauer entry. [GO_REF:0000058, GOC:TermGenie, PMID:21531333]"}
{"concept_id": "C4327331", "aliases": ["regulation of nematode entry into dormancy"], "types": ["T040"], "canonical_name": "regulation of dauer entry", "definition": "Any process that modulates the frequency, rate or extent of dauer entry. [GO_REF:0000058, GOC:TermGenie, PMID:21531333]"}
{"concept_id": "C4327332", "aliases": ["up-regulation of amyloid fibril formation", "up regulation of amyloid fibril formation", "upregulation of amyloid fibril formation"], "types": ["T044"], "canonical_name": "positive regulation of amyloid fibril formation", "definition": "Any process that activates or increases the frequency, rate or extent of amyloid fibril formation. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]"}
{"concept_id": "C4327333", "aliases": ["down regulation of amyloid fibril formation", "down-regulation of amyloid fibril formation", "downregulation of amyloid fibril formation"], "types": ["T044"], "canonical_name": "negative regulation of amyloid fibril formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]"}
{"concept_id": "C4327334", "aliases": [], "types": ["T044"], "canonical_name": "regulation of amyloid fibril formation", "definition": "Any process that modulates the frequency, rate or extent of amyloid fibril formation. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]"}
{"concept_id": "C4327335", "aliases": ["pharynx gland morphogenesis"], "types": ["T042"], "canonical_name": "pharyngeal gland morphogenesis", "definition": "The developmental process by which a pharyngeal gland is generated and organized. [GO_REF:0000083, GOC:TermGenie, PMID:21868609]"}
{"concept_id": "C4327336", "aliases": ["up regulation of mesoderm formation", "up-regulation of mesoderm formation", "upregulation of mesoderm formation"], "types": ["T042"], "canonical_name": "positive regulation of mesoderm formation", "definition": "Any process that activates or increases the frequency, rate or extent of mesoderm formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]"}
{"concept_id": "C4327337", "aliases": ["downregulation of mesoderm formation", "down regulation of mesoderm formation", "down-regulation of mesoderm formation"], "types": ["T042"], "canonical_name": "negative regulation of mesoderm formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]"}
{"concept_id": "C4327338", "aliases": [], "types": ["T042"], "canonical_name": "regulation of mesoderm formation", "definition": "Any process that modulates the frequency, rate or extent of mesoderm formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]"}
{"concept_id": "C4327339", "aliases": ["upregulation of smooth muscle tissue development", "up-regulation of smooth muscle tissue development", "up regulation of smooth muscle tissue development"], "types": ["T042"], "canonical_name": "positive regulation of smooth muscle tissue development", "definition": "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]"}
{"concept_id": "C4327340", "aliases": ["down-regulation of smooth muscle tissue development", "down regulation of smooth muscle tissue development", "downregulation of smooth muscle tissue development"], "types": ["T042"], "canonical_name": "negative regulation of smooth muscle tissue development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]"}
{"concept_id": "C4327341", "aliases": [], "types": ["T042"], "canonical_name": "regulation of smooth muscle tissue development", "definition": "Any process that modulates the frequency, rate or extent of smooth muscle tissue development. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]"}
{"concept_id": "C4327342", "aliases": ["up-regulation of response to ER stress", "upregulation of response to endoplasmic reticulum stress", "upregulation of cellular response to endoplasmic reticulum stress", "upregulation of ER stress response", "up regulation of ER stress response", "up-regulation of response to endoplasmic reticulum stress", "up-regulation of ER stress response", "upregulation of response to ER stress", "positive regulation of cellular response to endoplasmic reticulum stress", "up regulation of response to endoplasmic reticulum stress", "up regulation of cellular response to endoplasmic reticulum stress", "up-regulation of cellular response to endoplasmic reticulum stress", "up regulation of response to ER stress", "positive regulation of ER stress response", "positive regulation of response to ER stress"], "types": ["T043"], "canonical_name": "positive regulation of response to endoplasmic reticulum stress", "definition": "Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]"}
{"concept_id": "C4327343", "aliases": ["regulation of response to ER stress", "regulation of ER stress response", "regulation of cellular response to endoplasmic reticulum stress"], "types": ["T043"], "canonical_name": "regulation of response to endoplasmic reticulum stress", "definition": "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]"}
{"concept_id": "C4327344", "aliases": ["upregulation of cellular response to tunicamycin", "up regulation of cellular response to tunicamycin", "up-regulation of cellular response to tunicamycin"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to tunicamycin", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to tunicamycin. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]"}
{"concept_id": "C4327345", "aliases": ["downregulation of cellular response to tunicamycin", "down-regulation of cellular response to tunicamycin", "down regulation of cellular response to tunicamycin"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to tunicamycin", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to tunicamycin. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]"}
{"concept_id": "C4327346", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to tunicamycin", "definition": "Any process that modulates the frequency, rate or extent of cellular response to tunicamycin. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]"}
{"concept_id": "C4327347", "aliases": ["upregulation of cellular response to thapsigargin", "up-regulation of cellular response to thapsigargin", "up regulation of cellular response to thapsigargin"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to thapsigargin", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to thapsigargin. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]"}
{"concept_id": "C4327348", "aliases": ["down-regulation of cellular response to thapsigargin", "down regulation of cellular response to thapsigargin", "downregulation of cellular response to thapsigargin"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to thapsigargin", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to thapsigargin. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]"}
{"concept_id": "C4327349", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to thapsigargin", "definition": "Any process that modulates the frequency, rate or extent of cellular response to thapsigargin. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]"}
{"concept_id": "C4327350", "aliases": ["regulation of cellular response to VLDL particle stimulus"], "types": ["T043"], "canonical_name": "regulation of cellular response to very-low-density lipoprotein particle stimulus", "definition": "Any process that modulates the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957]"}
{"concept_id": "C4327351", "aliases": ["up regulation of cellular response to very-low-density lipoprotein particle stimulus", "upregulation of cellular response to very-low-density lipoprotein particle stimulus", "positive regulation of cellular response to VLDL particle stimulus", "up regulation of cellular response to VLDL particle stimulus", "up-regulation of cellular response to VLDL particle stimulus", "upregulation of cellular response to VLDL particle stimulus", "up-regulation of cellular response to very-low-density lipoprotein particle stimulus"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to very-low-density lipoprotein particle stimulus", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957]"}
{"concept_id": "C4327352", "aliases": ["negative regulation of cellular response to VLDL particle stimulus", "downregulation of cellular response to very-low-density lipoprotein particle stimulus", "down regulation of cellular response to very-low-density lipoprotein particle stimulus", "down regulation of cellular response to VLDL particle stimulus", "down-regulation of cellular response to VLDL particle stimulus", "downregulation of cellular response to VLDL particle stimulus", "down-regulation of cellular response to very-low-density lipoprotein particle stimulus"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to very-low-density lipoprotein particle stimulus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957]"}
{"concept_id": "C4327353", "aliases": ["(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol transmembrane transport", "AI-2 transmembrane transport", "autoinducer 2 transmembrane transport"], "types": ["T043"], "canonical_name": "autoinducer AI-2 transmembrane transport", "definition": "The process in which (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol (autoinducer AI-2) is transported across a membrane. AI-2 is produced by prokaryotes and is believed to play a role in quorum sensing. [GO_REF:0000069, GOC:TermGenie, PMID:15601708]"}
{"concept_id": "C4327355", "aliases": ["upregulation of triacylglycerol transport", "up regulation of triacylglycerol transport", "positive regulation of triacylglycerol transport", "up-regulation of triglyceride transport", "upregulation of triglyceride transport", "up regulation of triglyceride transport", "up-regulation of triacylglycerol transport"], "types": ["T044"], "canonical_name": "positive regulation of triglyceride transport", "definition": "Any process that activates or increases the frequency, rate or extent of triglyceride transport. [GO_REF:0000058, GOC:TermGenie, PMID:25849533]"}
{"concept_id": "C4327356", "aliases": ["down regulation of triacylglycerol transport", "downregulation of triacylglycerol transport", "downregulation of triglyceride transport", "negative regulation of triacylglycerol transport", "down-regulation of triglyceride transport", "down regulation of triglyceride transport", "down-regulation of triacylglycerol transport"], "types": ["T044"], "canonical_name": "negative regulation of triglyceride transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride transport. [GO_REF:0000058, GOC:TermGenie, PMID:25849533]"}
{"concept_id": "C4327357", "aliases": ["regulation of triacylglycerol transport"], "types": ["T044"], "canonical_name": "regulation of triglyceride transport", "definition": "Any process that modulates the frequency, rate or extent of triglyceride transport. [GO_REF:0000058, GOC:TermGenie, PMID:25849533]"}
{"concept_id": "C4327358", "aliases": ["positive regulation of ovum development", "up-regulation of ovum development", "up-regulation of oogenesis", "up regulation of oogenesis", "upregulation of ovum development", "up regulation of ovum development", "upregulation of oogenesis"], "types": ["T043"], "canonical_name": "positive regulation of oogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of oogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:26434723]"}
{"concept_id": "C4327359", "aliases": ["down regulation of oogenesis", "down-regulation of ovum development", "downregulation of oogenesis", "downregulation of ovum development", "negative regulation of ovum development", "down regulation of ovum development", "down-regulation of oogenesis"], "types": ["T043"], "canonical_name": "negative regulation of oogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:26434723]"}
{"concept_id": "C4327360", "aliases": ["regulation of ovum development"], "types": ["T039"], "canonical_name": "regulation of oogenesis", "definition": "Any process that modulates the frequency, rate or extent of oogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:26434723]"}
{"concept_id": "C4327363", "aliases": ["up regulation of postsynaptic density organization", "up-regulation of post-synaptic density organization", "up regulation of post-synaptic density organization", "upregulation of postsynaptic density organization", "upregulation of post synaptic density organization", "up regulation of post synaptic density organization", "positive regulation of PSD organization", "up regulation of postsynaptic density organisation", "up regulation of PSD organization", "positive regulation of post synaptic density organization", "upregulation of post-synaptic density organization", "upregulation of postsynaptic density organisation", "positive regulation of postsynaptic density organisation", "up-regulation of postsynaptic density organization", "up-regulation of post synaptic density organization", "positive regulation of post-synaptic density organization", "up-regulation of postsynaptic density organisation", "up-regulation of PSD organization", "upregulation of PSD organization"], "types": ["T043"], "canonical_name": "positive regulation of postsynaptic density organization", "definition": "Any process that activates or increases the frequency, rate or extent of postsynaptic density organization. [GO_REF:0000058, GOC:TermGenie, PMID:21887379]"}
{"concept_id": "C4327364", "aliases": ["down regulation of postsynaptic density organisation", "downregulation of postsynaptic density organization", "down-regulation of postsynaptic density organisation", "negative regulation of post synaptic density organization", "downregulation of post-synaptic density organization", "downregulation of post synaptic density organization", "down-regulation of post synaptic density organization", "downregulation of PSD organization", "down regulation of post-synaptic density organization", "down-regulation of postsynaptic density organization", "negative regulation of post-synaptic density organization", "down-regulation of post-synaptic density organization", "down-regulation of PSD organization", "down regulation of postsynaptic density organization", "down regulation of post synaptic density organization", "down regulation of PSD organization", "downregulation of postsynaptic density organisation", "negative regulation of PSD organization", "negative regulation of postsynaptic density organisation"], "types": ["T043"], "canonical_name": "negative regulation of postsynaptic density organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic density organization. [GO_REF:0000058, GOC:TermGenie, PMID:21887379]"}
{"concept_id": "C4327365", "aliases": ["regulation of post synaptic density organization", "regulation of postsynaptic density organisation", "regulation of post-synaptic density organization", "regulation of PSD organization"], "types": ["T043"], "canonical_name": "regulation of postsynaptic density organization", "definition": "Any process that modulates the frequency, rate or extent of postsynaptic density organization. [GO_REF:0000058, GOC:TermGenie, PMID:21887379]"}
{"concept_id": "C4327366", "aliases": ["up-regulation of protein localisation in cell leading edge", "up regulation of protein localization to cell leading edge", "up-regulation of protein localisation to cell leading edge", "up-regulation of protein localization in cell leading edge", "upregulation of protein localisation to cell leading edge", "up regulation of protein localization in cell leading edge", "positive regulation of protein localisation to cell leading edge", "upregulation of protein localization in cell leading edge", "positive regulation of protein localisation in cell leading edge", "up-regulation of protein localization to cell leading edge", "positive regulation of protein localization in cell leading edge", "upregulation of protein localization to cell leading edge", "up regulation of protein localisation in cell leading edge", "upregulation of protein localisation in cell leading edge", "up regulation of protein localisation to cell leading edge"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to cell leading edge", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge. [GO_REF:0000058, GOC:TermGenie, PMID:26324884]"}
{"concept_id": "C4327367", "aliases": ["down-regulation of protein localization to cell leading edge", "negative regulation of protein localisation in cell leading edge", "downregulation of protein localisation to cell leading edge", "down-regulation of protein localisation to cell leading edge", "down regulation of protein localization in cell leading edge", "negative regulation of protein localisation to cell leading edge", "downregulation of protein localization in cell leading edge", "negative regulation of protein localization in cell leading edge", "down-regulation of protein localization in cell leading edge", "down regulation of protein localisation in cell leading edge", "downregulation of protein localization to cell leading edge", "down regulation of protein localisation to cell leading edge", "down regulation of protein localization to cell leading edge", "downregulation of protein localisation in cell leading edge", "down-regulation of protein localisation in cell leading edge"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to cell leading edge", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. [GO_REF:0000058, GOC:TermGenie, PMID:26324884]"}
{"concept_id": "C4327368", "aliases": ["regulation of protein localisation in cell leading edge", "regulation of protein localisation to cell leading edge", "regulation of protein localization in cell leading edge"], "types": ["T043"], "canonical_name": "regulation of protein localization to cell leading edge", "definition": "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge. [GO_REF:0000058, GOC:TermGenie, PMID:26324884]"}
{"concept_id": "C4327369", "aliases": ["up-regulation of 3'-UTR-mediated mRNA stabilization", "positive regulation of 3'-untranslated region-mediated mRNA stabilization", "up regulation of 3'-untranslated region-mediated mRNA stabilization", "upregulation of 3'-UTR-mediated mRNA stabilization", "up-regulation of 3'-untranslated region-mediated mRNA stabilization", "up regulation of 3'-UTR-mediated mRNA stabilization", "upregulation of 3'-untranslated region-mediated mRNA stabilization"], "types": ["T045"], "canonical_name": "positive regulation of 3'-UTR-mediated mRNA stabilization", "definition": "Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization. [GO_REF:0000058, GOC:TermGenie, PMID:19737525]"}
{"concept_id": "C4327370", "aliases": ["negative regulation of 3'-untranslated region-mediated mRNA stabilization", "downregulation of 3'-untranslated region-mediated mRNA stabilization", "down-regulation of 3'-untranslated region-mediated mRNA stabilization", "down regulation of 3'-UTR-mediated mRNA stabilization", "down-regulation of 3'-UTR-mediated mRNA stabilization", "down regulation of 3'-untranslated region-mediated mRNA stabilization", "downregulation of 3'-UTR-mediated mRNA stabilization"], "types": ["T045"], "canonical_name": "negative regulation of 3'-UTR-mediated mRNA stabilization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization. [GO_REF:0000058, GOC:TermGenie, PMID:19737525]"}
{"concept_id": "C4327371", "aliases": ["regulation of 3'-untranslated region-mediated mRNA stabilization"], "types": ["T045"], "canonical_name": "regulation of 3'-UTR-mediated mRNA stabilization", "definition": "Any process that modulates the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization. [GO_REF:0000058, GOC:TermGenie, PMID:19737525]"}
{"concept_id": "C4327372", "aliases": ["epididymus development"], "types": ["T042"], "canonical_name": "epididymis development", "definition": "The process whose specific outcome is the progression of an epididymis over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, PMID:12388089]"}
{"concept_id": "C4327373", "aliases": ["upregulation of ULK1-ATG13-RB1CC1 complex formation", "up-regulation of ULK1-ATG13-RB1CC1 complex assembly", "up regulation of ATG1-ATG13 complex formation", "positive regulation of ULK1-ATG13-FIP200 complex formation", "up regulation of ATG1/ULK1 signaling complex assembly", "up regulation of ATG1-ATG13 complex assembly", "up regulation of ATG1 kinase complex assembly", "positive regulation of ATG1 kinase complex assembly", "up-regulation of ULK1-ATG13-RB1CC1 complex formation", "up-regulation of ATG1-ATG13 complex formation", "up-regulation of ATG1 kinase complex assembly", "up regulation of ATG1/ULK1 signaling complex formation", "up regulation of ULK1-ATG13-FIP200 complex formation", "up-regulation of ATG1/ULK1 kinase complex assembly", "upregulation of ULK1-ATG13-RB1CC1 complex assembly", "positive regulation of ATG1-ATG13 complex assembly", "upregulation of ATG1/ULK1 signaling complex assembly", "up-regulation of ULK1 signaling complex formation", "positive regulation of Atg1p signalling complex formation", "up-regulation of ATG1 kinase complex formation", "up-regulation of ATG1/ULK1 signaling complex formation", "up regulation of Atg1p signalling complex assembly", "up regulation of ULK1-ATG13-RB1CC1 complex formation", "positive regulation of ULK1 signaling complex formation", "up regulation of ATG1/ULK1 kinase complex assembly", "upregulation of ULK1-ATG13-FIP200 complex assembly", "positive regulation of ULK1 signaling complex assembly", "upregulation of ATG1/ULK1 kinase complex assembly", "positive regulation of ATG1 kinase complex formation", "up-regulation of ULK1-ATG13-FIP200 complex formation", "upregulation of Atg1p signalling complex formation", "positive regulation of ATG1/ULK1 kinase complex formation", "upregulation of ATG1-ATG13 complex assembly", "up-regulation of ULK1-ATG13-FIP200 complex assembly", "upregulation of ULK1-ATG13-FIP200 complex formation", "upregulation of ATG1-ATG13 complex formation", "upregulation of Atg1p signalling complex assembly", "up-regulation of ATG1/ULK1 signaling complex assembly", "upregulation of ULK1 signaling complex assembly", "up regulation of ULK1 signaling complex assembly", "up-regulation of ATG1-ATG13 complex assembly", "positive regulation of ATG1/ULK1 signaling complex assembly", "up-regulation of ULK1 signaling complex assembly", "positive regulation of ATG1-ATG13 complex formation", "upregulation of ULK1 signaling complex formation", "up-regulation of ATG1/ULK1 kinase complex formation", "up regulation of ULK1 signaling complex formation", "upregulation of ATG1 kinase complex assembly", "up-regulation of Atg1p signalling complex assembly", "positive regulation of ATG1/ULK1 signaling complex formation", "upregulation of ATG1/ULK1 kinase complex formation", "up regulation of ATG1 kinase complex formation", "up regulation of ULK1-ATG13-FIP200 complex assembly", "up regulation of ATG1/ULK1 kinase complex formation", "up regulation of Atg1p signalling complex formation", "positive regulation of ULK1-ATG13-FIP200 complex assembly", "positive regulation of Atg1p signalling complex assembly", "positive regulation of ULK1-ATG13-RB1CC1 complex assembly", "up-regulation of Atg1p signalling complex formation", "upregulation of ATG1/ULK1 signaling complex formation", "positive regulation of ULK1-ATG13-RB1CC1 complex formation", "up regulation of ULK1-ATG13-RB1CC1 complex assembly", "upregulation of ATG1 kinase complex formation"], "types": ["T043"], "canonical_name": "positive regulation of Atg1/ULK1 kinase complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of Atg1/ULK1 kinase complex assembly. [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215]"}
{"concept_id": "C4327374", "aliases": ["down-regulation of ULK1-ATG13-FIP200 complex formation", "downregulation of ATG1/ULK1 kinase complex assembly", "negative regulation of ATG1/ULK1 signaling complex formation", "downregulation of ATG1-ATG13 complex formation", "down regulation of ULK1-ATG13-FIP200 complex assembly", "downregulation of ULK1-ATG13-FIP200 complex assembly", "down regulation of ATG1/ULK1 signaling complex assembly", "down-regulation of ATG1 kinase complex assembly", "down-regulation of ULK1-ATG13-FIP200 complex assembly", "down regulation of Atg1p signalling complex formation", "downregulation of Atg1p signalling complex assembly", "negative regulation of ULK1-ATG13-FIP200 complex assembly", "down regulation of ULK1-ATG13-RB1CC1 complex formation", "down-regulation of Atg1p signalling complex formation", "downregulation of ULK1-ATG13-RB1CC1 complex assembly", "negative regulation of ATG1/ULK1 kinase complex formation", "down-regulation of ATG1/ULK1 signaling complex formation", "negative regulation of ATG1-ATG13 complex formation", "negative regulation of ATG1 kinase complex assembly", "down-regulation of ATG1 kinase complex formation", "downregulation of ATG1 kinase complex formation", "downregulation of Atg1p signalling complex formation", "down regulation of ATG1 kinase complex formation", "down-regulation of ULK1 signaling complex assembly", "negative regulation of Atg1p signalling complex formation", "down regulation of Atg1p signalling complex assembly", "down-regulation of ATG1-ATG13 complex formation", "down-regulation of ULK1-ATG13-RB1CC1 complex formation", "negative regulation of ULK1 signaling complex assembly", "down regulation of ULK1 signaling complex formation", "down regulation of ULK1 signaling complex assembly", "negative regulation of ATG1/ULK1 signaling complex assembly", "downregulation of ATG1 kinase complex assembly", "down regulation of ATG1/ULK1 kinase complex formation", "negative regulation of ULK1 signaling complex formation", "negative regulation of ULK1-ATG13-RB1CC1 complex assembly", "downregulation of ATG1/ULK1 signaling complex assembly", "down-regulation of ULK1 signaling complex formation", "down-regulation of ATG1/ULK1 kinase complex formation", "down regulation of ULK1-ATG13-RB1CC1 complex assembly", "negative regulation of ULK1-ATG13-RB1CC1 complex formation", "down-regulation of ULK1-ATG13-RB1CC1 complex assembly", "down regulation of ATG1/ULK1 signaling complex formation", "down-regulation of ATG1-ATG13 complex assembly", "down regulation of ATG1-ATG13 complex formation", "down regulation of ATG1 kinase complex assembly", "down-regulation of ATG1/ULK1 signaling complex assembly", "down regulation of ATG1-ATG13 complex assembly", "negative regulation of Atg1p signalling complex assembly", "downregulation of ATG1/ULK1 signaling complex formation", "downregulation of ULK1 signaling complex assembly", "down regulation of ULK1-ATG13-FIP200 complex formation", "downregulation of ULK1 signaling complex formation", "down-regulation of ATG1/ULK1 kinase complex assembly", "downregulation of ULK1-ATG13-RB1CC1 complex formation", "down regulation of ATG1/ULK1 kinase complex assembly", "downregulation of ULK1-ATG13-FIP200 complex formation", "down-regulation of Atg1p signalling complex assembly", "downregulation of ATG1/ULK1 kinase complex formation", "downregulation of ATG1-ATG13 complex assembly", "negative regulation of ULK1-ATG13-FIP200 complex formation", "negative regulation of ATG1-ATG13 complex assembly", "negative regulation of ATG1 kinase complex formation"], "types": ["T043"], "canonical_name": "negative regulation of Atg1/ULK1 kinase complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Atg1/ULK1 kinase complex assembly. [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215]"}
{"concept_id": "C4327375", "aliases": ["regulation of ATG1-ATG13 complex assembly", "regulation of ULK1 signaling complex assembly", "regulation of Atg1p signalling complex formation", "regulation of ATG1 kinase complex formation", "regulation of ULK1 signaling complex formation", "regulation of ATG1-ATG13 complex formation", "regulation of ULK1-ATG13-FIP200 complex assembly", "regulation of Atg1p signalling complex assembly", "regulation of ATG1/ULK1 signaling complex assembly", "regulation of ATG1/ULK1 signaling complex formation", "regulation of ULK1-ATG13-RB1CC1 complex formation", "regulation of ULK1-ATG13-RB1CC1 complex assembly", "regulation of ATG1/ULK1 kinase complex formation", "regulation of ULK1-ATG13-FIP200 complex formation", "regulation of ATG1 kinase complex assembly"], "types": ["T043"], "canonical_name": "regulation of Atg1/ULK1 kinase complex assembly", "definition": "Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly. [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215]"}
{"concept_id": "C4327377", "aliases": ["intranuclear rod formation", "intranuclear actin rod assembly", "intranuclear actin rod formation"], "types": ["T043"], "canonical_name": "intranuclear rod assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an intranuclear rod. [GO_REF:0000079, GOC:TermGenie, PMID:28074884]"}
{"concept_id": "C4327378", "aliases": ["upregulation of heparan sulfate proteoglycan binding", "up-regulation of heparan sulfate proteoglycan binding", "up regulation of heparan sulfate proteoglycan binding"], "types": ["T044"], "canonical_name": "positive regulation of heparan sulfate proteoglycan binding", "definition": "Any process that activates or increases the frequency, rate or extent of heparan sulfate proteoglycan binding. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]"}
{"concept_id": "C4327379", "aliases": ["downregulation of heparan sulfate proteoglycan binding", "down regulation of heparan sulfate proteoglycan binding", "down-regulation of heparan sulfate proteoglycan binding"], "types": ["T044"], "canonical_name": "negative regulation of heparan sulfate proteoglycan binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate proteoglycan binding. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]"}
{"concept_id": "C4327380", "aliases": [], "types": ["T044"], "canonical_name": "regulation of heparan sulfate proteoglycan binding", "definition": "Any process that modulates the frequency, rate or extent of heparan sulfate proteoglycan binding. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]"}
{"concept_id": "C4327381", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pentose-phosphate shunt", "definition": "Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt. [GO_REF:0000058, GOC:TermGenie, PMID:19015259]"}
{"concept_id": "C4327382", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of pentose-phosphate shunt", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of pentose-phosphate shunt. [GO_REF:0000058, GOC:TermGenie, PMID:19015259]"}
{"concept_id": "C4327383", "aliases": ["up-regulation of heparan sulfate binding", "upregulation of heparan sulfate binding", "up regulation of heparan sulfate binding"], "types": ["T044"], "canonical_name": "positive regulation of heparan sulfate binding", "definition": "Any process that activates or increases the frequency, rate or extent of heparan sulfate binding. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]"}
{"concept_id": "C4327384", "aliases": ["down regulation of heparan sulfate binding", "downregulation of heparan sulfate binding", "down-regulation of heparan sulfate binding"], "types": ["T044"], "canonical_name": "negative regulation of heparan sulfate binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate binding. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]"}
{"concept_id": "C4327385", "aliases": [], "types": ["T044"], "canonical_name": "regulation of heparan sulfate binding", "definition": "Any process that modulates the frequency, rate or extent of heparan sulfate binding. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]"}
{"concept_id": "C4327386", "aliases": ["upregulation of backward locomotion", "up-regulation of backward locomotion", "up regulation of backward locomotion"], "types": ["T040"], "canonical_name": "positive regulation of backward locomotion", "definition": "Any process that activates or increases the frequency, rate or extent of backward locomotion. [GO_REF:0000058, GOC:TermGenie, PMID:11717360]"}
{"concept_id": "C4327387", "aliases": ["down regulation of backward locomotion", "down-regulation of backward locomotion", "downregulation of backward locomotion"], "types": ["T040"], "canonical_name": "negative regulation of backward locomotion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of backward locomotion. [GO_REF:0000058, GOC:TermGenie, PMID:11717360]"}
{"concept_id": "C4327388", "aliases": ["up regulation of forward locomotion", "up-regulation of forward locomotion", "upregulation of forward locomotion"], "types": ["T040"], "canonical_name": "positive regulation of forward locomotion", "definition": "Any process that activates or increases the frequency, rate or extent of forward locomotion. [GO_REF:0000058, GOC:TermGenie, PMID:11717360]"}
{"concept_id": "C4327389", "aliases": ["down-regulation of forward locomotion", "downregulation of forward locomotion", "down regulation of forward locomotion"], "types": ["T040"], "canonical_name": "negative regulation of forward locomotion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of forward locomotion. [GO_REF:0000058, GOC:TermGenie, PMID:11717360]"}
{"concept_id": "C4327390", "aliases": ["up regulation of cellular response to oxidopamine", "up-regulation of cellular response to oxidopamine", "upregulation of cellular response to oxidopamine"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to oxidopamine", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to oxidopamine. [GO_REF:0000058, GOC:TermGenie, PMID:23721876]"}
{"concept_id": "C4327391", "aliases": ["down regulation of cellular response to oxidopamine", "down-regulation of cellular response to oxidopamine", "downregulation of cellular response to oxidopamine"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to oxidopamine", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidopamine. [GO_REF:0000058, GOC:TermGenie, PMID:23721876]"}
{"concept_id": "C4327392", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to oxidopamine", "definition": "Any process that modulates the frequency, rate or extent of cellular response to oxidopamine. [GO_REF:0000058, GOC:TermGenie, PMID:23721876]"}
{"concept_id": "C4327393", "aliases": ["up regulation of cellular response to gamma radiation", "up-regulation of cellular response to gamma radiation", "upregulation of cellular response to gamma radiation"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to gamma radiation", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to gamma radiation. [GO_REF:0000058, GOC:TermGenie, PMID:23505386]"}
{"concept_id": "C4327394", "aliases": ["down-regulation of cellular response to gamma radiation", "downregulation of cellular response to gamma radiation", "down regulation of cellular response to gamma radiation"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to gamma radiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation. [GO_REF:0000058, GOC:TermGenie, PMID:23505386]"}
{"concept_id": "C4327395", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to gamma radiation", "definition": "Any process that modulates the frequency, rate or extent of cellular response to gamma radiation. [GO_REF:0000058, GOC:TermGenie, PMID:23505386]"}
{"concept_id": "C4327396", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to oxidopamine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus. [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876]"}
{"concept_id": "C4327397", "aliases": [], "types": ["T043"], "canonical_name": "response to oxidopamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus. [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876]"}
{"concept_id": "C4327398", "aliases": ["up-regulation of telomeric D-loop disassembly", "upregulation of telomeric D-loop disassembly", "up regulation of telomeric D-loop disassembly"], "types": ["T045"], "canonical_name": "positive regulation of telomeric D-loop disassembly", "definition": "Any process that activates or increases the frequency, rate or extent of telomeric D-loop disassembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]"}
{"concept_id": "C4327399", "aliases": ["downregulation of telomeric D-loop disassembly", "down regulation of telomeric D-loop disassembly", "down-regulation of telomeric D-loop disassembly"], "types": ["T045"], "canonical_name": "negative regulation of telomeric D-loop disassembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric D-loop disassembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]"}
{"concept_id": "C4327400", "aliases": [], "types": ["T045"], "canonical_name": "regulation of telomeric D-loop disassembly", "definition": "Any process that modulates the frequency, rate or extent of telomeric D-loop disassembly. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]"}
{"concept_id": "C4327401", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to triterpenoid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:28078994]"}
{"concept_id": "C4327402", "aliases": [], "types": ["T043"], "canonical_name": "response to triterpenoid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:28078994]"}
{"concept_id": "C4327403", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to pyrimidine ribonucleotide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22065602]"}
{"concept_id": "C4327404", "aliases": [], "types": ["T043"], "canonical_name": "response to pyrimidine ribonucleotide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22065602]"}
{"concept_id": "C4327405", "aliases": ["downregulation of microtubule nucleation", "down regulation of microtubule nucleation", "down-regulation of microtubule nucleation"], "types": ["T043"], "canonical_name": "negative regulation of microtubule nucleation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. [GO_REF:0000058, GOC:TermGenie, PMID:27689799]"}
{"concept_id": "C4327406", "aliases": ["up regulation of spindle assembly", "upregulation of bipolar spindle biosynthesis", "up-regulation of spindle formation", "up-regulation of bipolar spindle biosynthesis", "up-regulation of spindle biosynthesis", "up-regulation of spindle assembly", "upregulation of bipolar spindle formation", "positive regulation of bipolar spindle formation", "up regulation of bipolar spindle biosynthesis", "upregulation of spindle formation", "positive regulation of spindle formation", "positive regulation of bipolar spindle biosynthesis", "upregulation of spindle assembly", "up-regulation of bipolar spindle formation", "positive regulation of spindle biosynthesis", "up regulation of bipolar spindle formation", "up regulation of spindle biosynthesis", "up regulation of spindle formation", "upregulation of spindle biosynthesis"], "types": ["T043"], "canonical_name": "positive regulation of spindle assembly", "definition": "Any process that activates or increases the frequency, rate or extent of spindle assembly. [GO_REF:0000058, GOC:TermGenie, PMID:27689799]"}
{"concept_id": "C4327407", "aliases": ["down regulation of bipolar spindle biosynthesis", "down regulation of spindle formation", "down-regulation of bipolar spindle formation", "negative regulation of spindle biosynthesis", "downregulation of spindle biosynthesis", "downregulation of spindle formation", "down-regulation of spindle assembly", "negative regulation of spindle formation", "negative regulation of bipolar spindle formation", "downregulation of spindle assembly", "downregulation of bipolar spindle formation", "down regulation of spindle biosynthesis", "down-regulation of spindle biosynthesis", "down-regulation of spindle formation", "down regulation of spindle assembly", "downregulation of bipolar spindle biosynthesis", "down regulation of bipolar spindle formation", "down-regulation of bipolar spindle biosynthesis", "negative regulation of bipolar spindle biosynthesis"], "types": ["T043"], "canonical_name": "negative regulation of spindle assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of spindle assembly. [GO_REF:0000058, GOC:TermGenie, PMID:27689799]"}
{"concept_id": "C4327408", "aliases": ["upregulation of prostaglandin breakdown", "up regulation of prostaglandin catabolism", "up-regulation of prostaglandin catabolic process", "upregulation of prostaglandin catabolic process", "up regulation of prostaglandin catabolic process", "upregulation of prostaglandin degradation", "positive regulation of prostaglandin breakdown", "positive regulation of prostaglandin degradation", "positive regulation of prostaglandin catabolism", "up regulation of prostaglandin breakdown", "up regulation of prostaglandin degradation", "upregulation of prostaglandin catabolism", "up-regulation of prostaglandin breakdown", "up-regulation of prostaglandin degradation", "up-regulation of prostaglandin catabolism"], "types": ["T044"], "canonical_name": "positive regulation of prostaglandin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of prostaglandin catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:12432938]"}
{"concept_id": "C4327409", "aliases": ["down regulation of prostaglandin degradation", "down regulation of prostaglandin catabolism", "negative regulation of prostaglandin catabolism", "downregulation of prostaglandin catabolism", "down-regulation of prostaglandin catabolism", "downregulation of prostaglandin catabolic process", "down-regulation of prostaglandin degradation", "down regulation of prostaglandin catabolic process", "down-regulation of prostaglandin catabolic process", "down regulation of prostaglandin breakdown", "downregulation of prostaglandin breakdown", "downregulation of prostaglandin degradation", "down-regulation of prostaglandin breakdown", "negative regulation of prostaglandin degradation", "negative regulation of prostaglandin breakdown"], "types": ["T044"], "canonical_name": "negative regulation of prostaglandin catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:12432938]"}
{"concept_id": "C4327410", "aliases": ["regulation of prostaglandin catabolism", "regulation of prostaglandin breakdown", "regulation of prostaglandin degradation"], "types": ["T043"], "canonical_name": "regulation of prostaglandin catabolic process", "definition": "Any process that modulates the frequency, rate or extent of prostaglandin catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:12432938]"}
{"concept_id": "C4327411", "aliases": ["up regulation of selenocysteine metabolism", "positive regulation of selenocysteine metabolism", "up-regulation of selenocysteine metabolism", "upregulation of selenocysteine metabolism", "upregulation of selenocysteine metabolic process", "up-regulation of selenocysteine metabolic process", "up regulation of selenocysteine metabolic process"], "types": ["T043"], "canonical_name": "positive regulation of selenocysteine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of selenocysteine metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:19716792]"}
{"concept_id": "C4327412", "aliases": ["negative regulation of selenocysteine metabolism", "down regulation of selenocysteine metabolism", "downregulation of selenocysteine metabolic process", "down-regulation of selenocysteine metabolism", "downregulation of selenocysteine metabolism", "down regulation of selenocysteine metabolic process", "down-regulation of selenocysteine metabolic process"], "types": ["T043"], "canonical_name": "negative regulation of selenocysteine metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:19716792]"}
{"concept_id": "C4327413", "aliases": ["regulation of selenocysteine metabolism"], "types": ["T044"], "canonical_name": "regulation of selenocysteine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of selenocysteine metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:19716792]"}
{"concept_id": "C4327414", "aliases": ["upregulation of mitotic sister chromatid arm separation", "up-regulation of mitotic sister chromatid arm separation", "up regulation of mitotic sister chromatid arm separation"], "types": ["T043"], "canonical_name": "positive regulation of mitotic sister chromatid arm separation", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid arm separation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790]"}
{"concept_id": "C4327415", "aliases": ["down-regulation of mitotic sister chromatid arm separation", "down regulation of mitotic sister chromatid arm separation", "downregulation of mitotic sister chromatid arm separation"], "types": ["T043"], "canonical_name": "negative regulation of mitotic sister chromatid arm separation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid arm separation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790]"}
{"concept_id": "C4327416", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic sister chromatid arm separation", "definition": "Any process that modulates the frequency, rate or extent of mitotic sister chromatid arm separation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790]"}
{"concept_id": "C4327417", "aliases": ["up-regulation of nuclear chromosome condensation", "upregulation of eukaryotic chromosome condensation", "upregulation of nuclear chromosome condensation", "upregulation of chromosome condensation", "up regulation of eukaryotic chromosome condensation", "up regulation of nuclear chromosome condensation", "positive regulation of nuclear chromosome condensation", "up-regulation of eukaryotic chromosome condensation", "positive regulation of eukaryotic chromosome condensation", "up-regulation of chromosome condensation", "up regulation of chromosome condensation"], "types": ["T043"], "canonical_name": "positive regulation of chromosome condensation", "definition": "Any process that activates or increases the frequency, rate or extent of chromosome condensation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547]"}
{"concept_id": "C4327418", "aliases": ["upregulation of chromosome separation", "up-regulation of chromosome separation", "up regulation of chromosome separation"], "types": ["T045"], "canonical_name": "positive regulation of chromosome separation", "definition": "Any process that activates or increases the frequency, rate or extent of chromosome separation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393]"}
{"concept_id": "C4327419", "aliases": ["downregulation of chromosome separation", "down regulation of chromosome separation", "down-regulation of chromosome separation"], "types": ["T043"], "canonical_name": "negative regulation of chromosome separation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome separation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393]"}
{"concept_id": "C4327420", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chromosome separation", "definition": "Any process that modulates the frequency, rate or extent of chromosome separation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393]"}
{"concept_id": "C4327421", "aliases": ["upregulation of dorsal/ventral axon pathfinding", "up regulation of dorsal-ventral axon guidance", "positive regulation of dorsal-ventral axon guidance", "up regulation of dorsal/ventral axon pathfinding", "up-regulation of dorsoventral axon guidance", "positive regulation of dorsoventral axon guidance", "up-regulation of dorsal/ventral axon guidance", "upregulation of dorsal-ventral axon guidance", "positive regulation of dorsal/ventral axon pathfinding", "upregulation of dorsal/ventral axon guidance", "upregulation of dorsoventral axon guidance", "up regulation of dorsoventral axon guidance", "up-regulation of dorsal/ventral axon pathfinding", "up-regulation of dorsal-ventral axon guidance", "up regulation of dorsal/ventral axon guidance"], "types": ["T043"], "canonical_name": "positive regulation of dorsal/ventral axon guidance", "definition": "Any process that activates or increases the frequency, rate or extent of dorsal/ventral axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:18434533]"}
{"concept_id": "C4327422", "aliases": ["downregulation of dorsal-ventral axon guidance", "down regulation of dorsoventral axon guidance", "down regulation of dorsal/ventral axon pathfinding", "down regulation of dorsal-ventral axon guidance", "down regulation of dorsal/ventral axon guidance", "negative regulation of dorsoventral axon guidance", "negative regulation of dorsal/ventral axon pathfinding", "downregulation of dorsal/ventral axon guidance", "down-regulation of dorsal-ventral axon guidance", "down-regulation of dorsoventral axon guidance", "downregulation of dorsal/ventral axon pathfinding", "down-regulation of dorsal/ventral axon guidance", "downregulation of dorsoventral axon guidance", "down-regulation of dorsal/ventral axon pathfinding", "negative regulation of dorsal-ventral axon guidance"], "types": ["T043"], "canonical_name": "negative regulation of dorsal/ventral axon guidance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dorsal/ventral axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:18434533]"}
{"concept_id": "C4327423", "aliases": ["regulation of dorsoventral axon guidance", "regulation of dorsal-ventral axon guidance", "regulation of dorsal/ventral axon pathfinding"], "types": ["T043"], "canonical_name": "regulation of dorsal/ventral axon guidance", "definition": "Any process that modulates the frequency, rate or extent of dorsal/ventral axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:18434533]"}
{"concept_id": "C4327424", "aliases": ["up regulation of motor neuron axon guidance", "up-regulation of motor neuron axon guidance", "up-regulation of motor axon guidance", "upregulation of motoneuron axon guidance", "upregulation of motor axon guidance", "positive regulation of motor axon pathfinding", "up regulation of motoneuron axon guidance", "positive regulation of motor axon guidance", "upregulation of motor neuron axon guidance", "up-regulation of motoneuron axon guidance", "up regulation of motor axon guidance", "up-regulation of motor axon pathfinding", "upregulation of motor axon pathfinding", "up regulation of motor axon pathfinding", "positive regulation of motoneuron axon guidance"], "types": ["T043"], "canonical_name": "positive regulation of motor neuron axon guidance", "definition": "Any process that activates or increases the frequency, rate or extent of motor neuron axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:18434533]"}
{"concept_id": "C4327425", "aliases": ["downregulation of motor axon guidance", "down-regulation of motor axon guidance", "down-regulation of motor neuron axon guidance", "downregulation of motoneuron axon guidance", "negative regulation of motor axon guidance", "downregulation of motor axon pathfinding", "down regulation of motor neuron axon guidance", "down-regulation of motor axon pathfinding", "negative regulation of motoneuron axon guidance", "down regulation of motor axon guidance", "negative regulation of motor axon pathfinding", "down-regulation of motoneuron axon guidance", "down regulation of motoneuron axon guidance", "down regulation of motor axon pathfinding", "downregulation of motor neuron axon guidance"], "types": ["T043"], "canonical_name": "negative regulation of motor neuron axon guidance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:18434533]"}
{"concept_id": "C4327426", "aliases": ["regulation of motor axon pathfinding", "regulation of motor axon guidance", "regulation of motoneuron axon guidance"], "types": ["T043"], "canonical_name": "regulation of motor neuron axon guidance", "definition": "Any process that modulates the frequency, rate or extent of motor neuron axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:18434533]"}
{"concept_id": "C4327427", "aliases": ["down regulation of excitatory synapse disassembly", "downregulation of excitatory synapse disassembly", "down-regulation of excitatory synapse disassembly"], "types": ["T043"], "canonical_name": "negative regulation of excitatory synapse pruning", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse pruning. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327428", "aliases": [], "types": ["T043"], "canonical_name": "regulation of excitatory synapse pruning", "definition": "Any process that modulates the frequency, rate or extent of excitatory synapse pruning. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327429", "aliases": ["negative regulation of synapse organisation", "downregulation of synapse organisation", "down regulation of synapse organization", "down-regulation of synapse organization", "downregulation of synapse organization", "negative regulation of synapse development", "down-regulation of synapse organisation", "down-regulation of synapse development", "downregulation of synapse development", "down regulation of synapse organisation", "down regulation of synapse development"], "types": ["T043"], "canonical_name": "negative regulation of synapse organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327430", "aliases": ["upregulation of synapse disassembly", "up regulation of synapse disassembly", "up-regulation of synapse disassembly"], "types": ["T043"], "canonical_name": "positive regulation of synapse pruning", "definition": "Any process that activates or increases the frequency, rate or extent of synapse pruning. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327431", "aliases": ["down-regulation of synapse disassembly", "down regulation of synapse disassembly", "downregulation of synapse disassembly"], "types": ["T043"], "canonical_name": "negative regulation of synapse pruning", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327432", "aliases": ["regulation of synapse disassembly", "regulation of synapse elimination", "regulation of synapse clearance", "regulation of synapse removal"], "types": ["T043"], "canonical_name": "regulation of synapse pruning", "definition": "Any process that modulates the frequency, rate or extent of synapse pruning. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327433", "aliases": [], "types": ["T043"], "canonical_name": "excitatory synapse pruning", "definition": "The disaggregation of an excitatory synapse into its constituent components. [GO_REF:0000079, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327434", "aliases": ["upregulation of cellular response to manganese", "up-regulation of cellular response to manganese", "upregulation of cellular response to manganese ion", "up-regulation of cellular response to manganese ion", "up regulation of cellular response to manganese", "up regulation of cellular response to manganese ion", "positive regulation of cellular response to manganese"], "types": ["T043"], "canonical_name": "positive regulation of cellular response to manganese ion", "definition": "Any process that activates or increases the frequency, rate or extent of cellular response to manganese ion. [GO_REF:0000058, GOC:TermGenie, PMID:23721876]"}
{"concept_id": "C4327435", "aliases": ["down-regulation of cellular response to manganese ion", "down-regulation of cellular response to manganese", "down regulation of cellular response to manganese", "negative regulation of cellular response to manganese", "downregulation of cellular response to manganese", "down regulation of cellular response to manganese ion", "downregulation of cellular response to manganese ion"], "types": ["T043"], "canonical_name": "negative regulation of cellular response to manganese ion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to manganese ion. [GO_REF:0000058, GOC:TermGenie, PMID:23721876]"}
{"concept_id": "C4327436", "aliases": ["regulation of cellular response to manganese"], "types": ["T043"], "canonical_name": "regulation of cellular response to manganese ion", "definition": "Any process that modulates the frequency, rate or extent of cellular response to manganese ion. [GO_REF:0000058, GOC:TermGenie, PMID:23721876]"}
{"concept_id": "C4327437", "aliases": ["up-regulation of intraflagellar retrograde transport", "up regulation of intraflagellar retrograde transport", "upregulation of intraflagellar retrograde transport", "up regulation of intraciliary retrograde transport", "positive regulation of intraflagellar retrograde transport", "up-regulation of intraciliary retrograde transport", "upregulation of intraciliary retrograde transport"], "types": ["T043"], "canonical_name": "positive regulation of intraciliary retrograde transport", "definition": "Any process that activates or increases the frequency, rate or extent of intraciliary retrograde transport. [GO_REF:0000058, GOC:TermGenie, PMID:27930654]"}
{"concept_id": "C4327438", "aliases": ["down regulation of intraciliary retrograde transport", "downregulation of intraflagellar retrograde transport", "down regulation of intraflagellar retrograde transport", "down-regulation of intraciliary retrograde transport", "downregulation of intraciliary retrograde transport", "negative regulation of intraflagellar retrograde transport", "down-regulation of intraflagellar retrograde transport"], "types": ["T043"], "canonical_name": "negative regulation of intraciliary retrograde transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary retrograde transport. [GO_REF:0000058, GOC:TermGenie, PMID:27930654]"}
{"concept_id": "C4327439", "aliases": ["regulation of intraflagellar retrograde transport"], "types": ["T043"], "canonical_name": "regulation of intraciliary retrograde transport", "definition": "Any process that modulates the frequency, rate or extent of intraciliary retrograde transport. [GO_REF:0000058, GOC:TermGenie, PMID:27930654]"}
{"concept_id": "C4327440", "aliases": ["upregulation of intraciliary anterograde transport", "up regulation of intraciliary anterograde transport", "up-regulation of intraflagellar anterograde transport", "up regulation of intraflagellar anterograde transport", "up-regulation of intraciliary anterograde transport", "positive regulation of intraflagellar anterograde transport", "upregulation of intraflagellar anterograde transport"], "types": ["T043"], "canonical_name": "positive regulation of intraciliary anterograde transport", "definition": "Any process that activates or increases the frequency, rate or extent of intraciliary anterograde transport. [GO_REF:0000058, GOC:TermGenie, PMID:27930654]"}
{"concept_id": "C4327441", "aliases": ["down regulation of intraciliary anterograde transport", "down-regulation of intraciliary anterograde transport", "downregulation of intraciliary anterograde transport", "negative regulation of intraflagellar anterograde transport", "down-regulation of intraflagellar anterograde transport", "down regulation of intraflagellar anterograde transport", "downregulation of intraflagellar anterograde transport"], "types": ["T043"], "canonical_name": "negative regulation of intraciliary anterograde transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary anterograde transport. [GO_REF:0000058, GOC:TermGenie, PMID:27930654]"}
{"concept_id": "C4327442", "aliases": ["regulation of intraflagellar anterograde transport"], "types": ["T043"], "canonical_name": "regulation of intraciliary anterograde transport", "definition": "Any process that modulates the frequency, rate or extent of intraciliary anterograde transport. [GO_REF:0000058, GOC:TermGenie, PMID:27930654]"}
{"concept_id": "C4327443", "aliases": ["cellular response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine"], "types": ["T043"], "canonical_name": "cellular response to puromycin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25736288]"}
{"concept_id": "C4327444", "aliases": ["response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine"], "types": ["T043"], "canonical_name": "response to puromycin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25736288]"}
{"concept_id": "C4327445", "aliases": ["protein localisation to pericentriolar material", "protein localisation in pericentriolar material", "protein localization in pericentriolar material"], "types": ["T043"], "canonical_name": "protein localization to pericentriolar material", "definition": "A process in which a protein is transported to, or maintained in, a location within a pericentriolar material. [GO_REF:0000087, GOC:TermGenie, PMID:21694707, PMID:24385583]"}
{"concept_id": "C4327446", "aliases": ["upregulation of mechanosensory behavior", "upregulation of behavioral response to mechanical stimulus", "up regulation of mechanosensory behaviour", "up-regulation of behavioural response to mechanical stimulus", "positive regulation of behavioral response to mechanical stimulus", "positive regulation of mechanosensory behaviour", "up-regulation of mechanosensory behavior", "up-regulation of mechanosensory behaviour", "up-regulation of behavioral response to mechanical stimulus", "upregulation of mechanosensory behaviour", "up regulation of behavioural response to mechanical stimulus", "up regulation of behavioral response to mechanical stimulus", "positive regulation of behavioural response to mechanical stimulus", "up regulation of mechanosensory behavior", "upregulation of behavioural response to mechanical stimulus"], "types": ["T040"], "canonical_name": "positive regulation of mechanosensory behavior", "definition": "Any process that activates or increases the frequency, rate or extent of mechanosensory behavior. [GO_REF:0000058, GOC:TermGenie, PMID:8692859]"}
{"concept_id": "C4327447", "aliases": ["down-regulation of mechanosensory behavior", "down regulation of behavioural response to mechanical stimulus", "down regulation of mechanosensory behavior", "down-regulation of mechanosensory behaviour", "downregulation of behavioral response to mechanical stimulus", "downregulation of mechanosensory behavior", "negative regulation of mechanosensory behaviour", "down regulation of behavioral response to mechanical stimulus", "negative regulation of behavioral response to mechanical stimulus", "downregulation of mechanosensory behaviour", "down regulation of mechanosensory behaviour", "down-regulation of behavioral response to mechanical stimulus", "downregulation of behavioural response to mechanical stimulus", "down-regulation of behavioural response to mechanical stimulus", "negative regulation of behavioural response to mechanical stimulus"], "types": ["T040"], "canonical_name": "negative regulation of mechanosensory behavior", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mechanosensory behavior. [GO_REF:0000058, GOC:TermGenie, PMID:8692859]"}
{"concept_id": "C4327448", "aliases": ["regulation of behavioural response to mechanical stimulus", "regulation of behavioral response to mechanical stimulus", "regulation of mechanosensory behaviour"], "types": ["T040"], "canonical_name": "regulation of mechanosensory behavior", "definition": "Any process that modulates the frequency, rate or extent of mechanosensory behavior. [GO_REF:0000058, GOC:TermGenie, PMID:8692859]"}
{"concept_id": "C4327449", "aliases": ["positive regulation of perception of touch, sensory detection of mechanical stimulus", "positive regulation of sensory transduction of mechanical stimulus during perception of touch", "up-regulation of perception of touch, sensory detection of mechanical stimulus", "up-regulation of tactition, sensory detection of mechanical stimulus", "upregulation of tactition, sensory detection of mechanical stimulus", "upregulation of sensory detection of mechanical stimulus during perception of touch", "up-regulation of perception of touch, detection of mechanical stimulus", "up-regulation of sensory detection of mechanical stimulus during perception of touch", "up regulation of perception of touch, sensory transduction of mechanical stimulus", "up-regulation of detection of mechanical stimulus involved in sensory perception of touch", "upregulation of perception of touch, sensory transduction of mechanical stimulus", "upregulation of detection of mechanical stimulus involved in sensory perception of touch", "up-regulation of perception of touch, sensory transduction of mechanical stimulus", "upregulation of perception of touch, sensory detection of mechanical stimulus", "up regulation of detection of mechanical stimulus involved in sensory perception of touch", "up regulation of perception of touch, detection of mechanical stimulus", "positive regulation of perception of touch, detection of mechanical stimulus", "up regulation of sensory detection of mechanical stimulus during perception of touch", "up regulation of tactition, sensory detection of mechanical stimulus", "positive regulation of tactition, sensory detection of mechanical stimulus", "positive regulation of sensory detection of mechanical stimulus during perception of touch", "positive regulation of perception of touch, sensory transduction of mechanical stimulus", "up-regulation of sensory transduction of mechanical stimulus during perception of touch", "up regulation of perception of touch, sensory detection of mechanical stimulus", "upregulation of perception of touch, detection of mechanical stimulus", "upregulation of sensory transduction of mechanical stimulus during perception of touch", "up regulation of sensory transduction of mechanical stimulus during perception of touch"], "types": ["T040"], "canonical_name": "positive regulation of detection of mechanical stimulus involved in sensory perception of touch", "definition": "Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. [GO_REF:0000058, GOC:TermGenie, PMID:8692859]"}
{"concept_id": "C4327450", "aliases": ["downregulation of sensory transduction of mechanical stimulus during perception of touch", "down-regulation of sensory detection of mechanical stimulus during perception of touch", "down-regulation of perception of touch, detection of mechanical stimulus", "negative regulation of tactition, sensory detection of mechanical stimulus", "down-regulation of tactition, sensory detection of mechanical stimulus", "downregulation of detection of mechanical stimulus involved in sensory perception of touch", "downregulation of perception of touch, sensory transduction of mechanical stimulus", "downregulation of perception of touch, detection of mechanical stimulus", "down-regulation of perception of touch, sensory transduction of mechanical stimulus", "down regulation of perception of touch, detection of mechanical stimulus", "down regulation of perception of touch, sensory transduction of mechanical stimulus", "down-regulation of perception of touch, sensory detection of mechanical stimulus", "down-regulation of sensory transduction of mechanical stimulus during perception of touch", "down regulation of sensory detection of mechanical stimulus during perception of touch", "downregulation of sensory detection of mechanical stimulus during perception of touch", "downregulation of tactition, sensory detection of mechanical stimulus", "down regulation of perception of touch, sensory detection of mechanical stimulus", "negative regulation of perception of touch, sensory detection of mechanical stimulus", "down regulation of sensory transduction of mechanical stimulus during perception of touch", "negative regulation of sensory transduction of mechanical stimulus during perception of touch", "negative regulation of perception of touch, sensory transduction of mechanical stimulus", "down regulation of detection of mechanical stimulus involved in sensory perception of touch", "down-regulation of detection of mechanical stimulus involved in sensory perception of touch", "down regulation of tactition, sensory detection of mechanical stimulus", "downregulation of perception of touch, sensory detection of mechanical stimulus", "negative regulation of perception of touch, detection of mechanical stimulus", "negative regulation of sensory detection of mechanical stimulus during perception of touch"], "types": ["T040"], "canonical_name": "negative regulation of detection of mechanical stimulus involved in sensory perception of touch", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. [GO_REF:0000058, GOC:TermGenie, PMID:8692859]"}
{"concept_id": "C4327451", "aliases": ["regulation of tactition, sensory detection of mechanical stimulus", "regulation of perception of touch, sensory transduction of mechanical stimulus", "regulation of perception of touch, sensory detection of mechanical stimulus", "regulation of sensory detection of mechanical stimulus during perception of touch", "regulation of perception of touch, detection of mechanical stimulus", "regulation of sensory transduction of mechanical stimulus during perception of touch"], "types": ["T040"], "canonical_name": "regulation of detection of mechanical stimulus involved in sensory perception of touch", "definition": "Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. [GO_REF:0000058, GOC:TermGenie, PMID:8692859]"}
{"concept_id": "C4327452", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of anaphase-promoting complex-dependent catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10921876]"}
{"concept_id": "C4327453", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of anaphase-promoting complex-dependent catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10921876]"}
{"concept_id": "C4327454", "aliases": [], "types": ["T043"], "canonical_name": "regulation of anaphase-promoting complex-dependent catabolic process", "definition": "Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10921876]"}
{"concept_id": "C4327456", "aliases": ["up-regulation of phosphatidylserine exposure on apoptotic cell surface", "upregulation of externalization of phosphatidylserine", "positive regulation of externalization of phosphatidylserine", "up-regulation of externalization of phosphatidylserine", "up regulation of externalization of phosphatidylserine", "upregulation of phosphatidylserine exposure on apoptotic cell surface", "up regulation of phosphatidylserine exposure on apoptotic cell surface"], "types": ["T043"], "canonical_name": "positive regulation of phosphatidylserine exposure on apoptotic cell surface", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362]"}
{"concept_id": "C4327457", "aliases": ["down-regulation of externalization of phosphatidylserine", "down regulation of externalization of phosphatidylserine", "down regulation of phosphatidylserine exposure on apoptotic cell surface", "downregulation of phosphatidylserine exposure on apoptotic cell surface", "downregulation of externalization of phosphatidylserine", "down-regulation of phosphatidylserine exposure on apoptotic cell surface", "negative regulation of externalization of phosphatidylserine"], "types": ["T043"], "canonical_name": "negative regulation of phosphatidylserine exposure on apoptotic cell surface", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362]"}
{"concept_id": "C4327458", "aliases": ["regulation of externalization of phosphatidylserine"], "types": ["T043"], "canonical_name": "regulation of phosphatidylserine exposure on apoptotic cell surface", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362]"}
{"concept_id": "C4327459", "aliases": ["up regulation of exonuclease activity", "up-regulation of exonuclease activity", "upregulation of exonuclease activity"], "types": ["T044"], "canonical_name": "positive regulation of exonuclease activity", "definition": "Any process that activates or increases the frequency, rate or extent of exonuclease activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]"}
{"concept_id": "C4327460", "aliases": ["down regulation of exonuclease activity", "downregulation of exonuclease activity", "down-regulation of exonuclease activity"], "types": ["T044"], "canonical_name": "negative regulation of exonuclease activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of exonuclease activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]"}
{"concept_id": "C4327461", "aliases": [], "types": ["T044"], "canonical_name": "regulation of exonuclease activity", "definition": "Any process that modulates the frequency, rate or extent of exonuclease activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954]"}
{"concept_id": "C4327462", "aliases": ["positive regulation of ATP-dependent DNA helicase activity"], "types": ["T044"], "canonical_name": "positive regulation of DNA helicase activity", "definition": "Any process that activates or increases the frequency, rate or extent of ATP-dependent DNA helicase activity. [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539]"}
{"concept_id": "C4327463", "aliases": ["negative regulation of ATP-dependent DNA helicase activity"], "types": ["T045"], "canonical_name": "negative regulation of DNA helicase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity. [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539]"}
{"concept_id": "C4327464", "aliases": ["regulation of ATP-dependent DNA helicase activity"], "types": ["T045"], "canonical_name": "regulation of DNA helicase activity", "definition": "Any process that modulates the frequency, rate or extent of ATP-dependent DNA helicase activity. [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539]"}
{"concept_id": "C4327465", "aliases": [], "types": ["T045"], "canonical_name": "8-hydroxy-2'-deoxyguanosine DNA binding", "definition": "Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA. [GO_REF:0000067, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19734539]"}
{"concept_id": "C4327466", "aliases": ["up regulation of mesodermal cell differentiation", "upregulation of mesoderm cell differentiation", "up regulation of mesoderm cell differentiation", "positive regulation of mesoderm cell differentiation", "up-regulation of mesoderm cell differentiation", "upregulation of mesodermal cell differentiation", "up-regulation of mesodermal cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of mesodermal cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]"}
{"concept_id": "C4327467", "aliases": ["downregulation of mesoderm cell differentiation", "down regulation of mesoderm cell differentiation", "downregulation of mesodermal cell differentiation", "down regulation of mesodermal cell differentiation", "down-regulation of mesoderm cell differentiation", "negative regulation of mesoderm cell differentiation", "down-regulation of mesodermal cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of mesodermal cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]"}
{"concept_id": "C4327468", "aliases": ["regulation of mesoderm cell differentiation"], "types": ["T043"], "canonical_name": "regulation of mesodermal cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]"}
{"concept_id": "C4327469", "aliases": ["upregulation of double-stranded telomeric DNA binding", "up-regulation of double-stranded telomeric DNA binding", "up regulation of double-stranded telomeric DNA binding"], "types": ["T045"], "canonical_name": "positive regulation of double-stranded telomeric DNA binding", "definition": "Any process that activates or increases the frequency, rate or extent of double-stranded telomeric DNA binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185]"}
{"concept_id": "C4327470", "aliases": ["down regulation of double-stranded telomeric DNA binding", "downregulation of double-stranded telomeric DNA binding", "down-regulation of double-stranded telomeric DNA binding"], "types": ["T045"], "canonical_name": "negative regulation of double-stranded telomeric DNA binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of double-stranded telomeric DNA binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185]"}
{"concept_id": "C4327471", "aliases": [], "types": ["T045"], "canonical_name": "regulation of double-stranded telomeric DNA binding", "definition": "Any process that modulates the frequency, rate or extent of double-stranded telomeric DNA binding. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185]"}
{"concept_id": "C4327472", "aliases": ["positive regulation of protection from NHEJ-mediated telomere fusion", "upregulation of protection from NHEJ-mediated telomere fusion", "up regulation of protection from non-homologous end joining at telomere", "up regulation of protection from NHEJ-mediated telomere fusion", "up-regulation of protection from non-homologous end joining at telomere", "upregulation of protection from non-homologous end joining at telomere", "up-regulation of protection from NHEJ-mediated telomere fusion"], "types": ["T045"], "canonical_name": "positive regulation of protection from non-homologous end joining at telomere", "definition": "Any process that activates or increases the frequency, rate or extent of protection from non-homologous end joining at telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602]"}
{"concept_id": "C4327473", "aliases": ["down-regulation of protection from non-homologous end joining at telomere", "negative regulation of protection from NHEJ-mediated telomere fusion", "downregulation of protection from non-homologous end joining at telomere", "down regulation of protection from non-homologous end joining at telomere", "downregulation of protection from NHEJ-mediated telomere fusion", "down regulation of protection from NHEJ-mediated telomere fusion", "down-regulation of protection from NHEJ-mediated telomere fusion"], "types": ["T045"], "canonical_name": "negative regulation of protection from non-homologous end joining at telomere", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protection from non-homologous end joining at telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602]"}
{"concept_id": "C4327474", "aliases": ["regulation of protection from NHEJ-mediated telomere fusion"], "types": ["T045"], "canonical_name": "regulation of protection from non-homologous end joining at telomere", "definition": "Any process that modulates the frequency, rate or extent of protection from non-homologous end joining at telomere. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602]"}
{"concept_id": "C4327475", "aliases": ["PAXT complex binding", "Mtl1-Red1 core complex binding", "NURS complex binding"], "types": ["T044"], "canonical_name": "MTREC complex binding", "definition": "Binding to a MTREC complex. [GOC:TermGenie, PMID:26942678]"}
{"concept_id": "C4327476", "aliases": [], "types": ["T044"], "canonical_name": "CCR4-NOT complex binding", "definition": "Binding to a CCR4-NOT complex. [GOC:TermGenie, PMID:26942678]"}
{"concept_id": "C4327477", "aliases": ["SCF complex binding", "CRL1 complex binding", "CDL1 complex binding", "Cul1-RING ubiquitin ligase complex binding", "Skp1/Cul1/F-box protein complex binding", "cullin-RING ligase 1 binding"], "types": ["T044"], "canonical_name": "SCF ubiquitin ligase complex binding", "definition": "Binding to a SCF ubiquitin ligase complex. [GOC:dph, GOC:ha, GOC:TermGenie, PMID:19723762]"}
{"concept_id": "C4327478", "aliases": ["microtubule end of microtubulus of post-anaphase microtubule array", "microtubule end of microtubule of PAA", "microtubule end of microtubuli of post-anaphase microtubule array", "microtubule end of post-anaphase array microtubule", "microtubule end of microtubule of post-anaphase array", "microtubule end of microtubule of post-anaphase microtubule array", "microtubule end of microtubulus of PAA", "microtubule end of microtubulus of post-anaphase array", "microtubule end of microtubuli of PAA", "microtubule end of microtubuli of post-anaphase array"], "types": ["T026"], "canonical_name": "post-anaphase array microtubule end", "definition": "Any microtubule end that is part of a post-anaphase array microtubule. [GO_REF:0000064, GOC:TermGenie, PMID:11007487]"}
{"concept_id": "C4327479", "aliases": ["microtubule of PAA", "microtubuli of PAA", "microtubulus of post-anaphase microtubule array", "microtubule of post-anaphase array", "microtubulus of post-anaphase array", "microtubulus of PAA", "microtubuli of post-anaphase array", "microtubuli of post-anaphase microtubule array", "microtubule of post-anaphase microtubule array"], "types": ["T026"], "canonical_name": "post-anaphase array microtubule", "definition": "Any microtubule that is part of a post-anaphase microtubule array. [GO_REF:0000064, GOC:TermGenie, PMID:11007487]"}
{"concept_id": "C4327480", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of primary cell septum biogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of primary cell septum biogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:27898700]"}
{"concept_id": "C4327481", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of primary cell septum biogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of primary cell septum biogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:27898700]"}
{"concept_id": "C4327482", "aliases": [], "types": ["T043"], "canonical_name": "regulation of primary cell septum biogenesis", "definition": "Any process that modulates the frequency, rate or extent of primary cell septum biogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:27898700]"}
{"concept_id": "C4327483", "aliases": ["protein localisation to cytoplasmic microtubule"], "types": ["T043"], "canonical_name": "protein localization to cytoplasmic microtubule", "definition": "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule. [GO_REF:0000087, GOC:TermGenie, PMID:15177031]"}
{"concept_id": "C4327484", "aliases": ["cell nucleus of ascospore-type prospore", "nucleus of ascospore-type prospore"], "types": ["T026"], "canonical_name": "ascospore-type prospore nucleus", "definition": "Any nucleus that is part of a ascospore-type prospore. [GO_REF:0000064, GOC:TermGenie, PMID:26942678]"}
{"concept_id": "C4327485", "aliases": ["positive regulation of argininosuccinate synthetase activity", "up regulation of argininosuccinate synthetase activity", "up-regulation of citrulline--aspartate ligase activity", "up-regulation of argininosuccinate synthetase activity", "up-regulation of argininosuccinate synthase activity", "up regulation of L-citrulline:L-aspartate ligase (AMP-forming)", "up regulation of citrulline--aspartate ligase activity", "up-regulation of argininosuccinic acid synthetase activity", "up regulation of argininosuccinate synthase activity", "upregulation of argininosuccinate synthetase activity", "up-regulation of arginosuccinate synthetase activity", "upregulation of arginosuccinate synthetase activity", "upregulation of citrulline--aspartate ligase activity", "up-regulation of arginine succinate synthetase activity", "positive regulation of argininosuccinic acid synthetase activity", "positive regulation of arginine succinate synthetase activity", "upregulation of arginine succinate synthetase activity", "positive regulation of citrulline--aspartate ligase activity", "upregulation of argininosuccinate synthase activity", "up regulation of argininosuccinic acid synthetase activity", "up-regulation of L-citrulline:L-aspartate ligase (AMP-forming)", "upregulation of L-citrulline:L-aspartate ligase (AMP-forming)", "upregulation of argininosuccinic acid synthetase activity", "up regulation of arginosuccinate synthetase activity", "positive regulation of L-citrulline:L-aspartate ligase (AMP-forming)", "positive regulation of arginosuccinate synthetase activity", "up regulation of arginine succinate synthetase activity"], "types": ["T044"], "canonical_name": "positive regulation of argininosuccinate synthase activity", "definition": "Any process that activates or increases the frequency, rate or extent of argininosuccinate synthase activity. [GO_REF:0000059, GOC:TermGenie, PMID:19491403]"}
{"concept_id": "C4327486", "aliases": ["regulation of citrulline--aspartate ligase activity", "regulation of arginosuccinate synthetase activity", "regulation of L-citrulline:L-aspartate ligase (AMP-forming)", "regulation of argininosuccinic acid synthetase activity", "regulation of argininosuccinate synthetase activity", "regulation of arginine succinate synthetase activity"], "types": ["T044"], "canonical_name": "regulation of argininosuccinate synthase activity", "definition": "Any process that modulates the frequency, rate or extent of argininosuccinate synthase activity. [GO_REF:0000059, GOC:TermGenie, PMID:19491403]"}
{"concept_id": "C4327487", "aliases": ["up-regulation of endosome to plasma membrane protein transport", "upregulation of endosome to plasma membrane protein transport", "up regulation of endosome to plasma membrane protein transport"], "types": ["T043"], "canonical_name": "positive regulation of endosome to plasma membrane protein transport", "definition": "Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:22869721]"}
{"concept_id": "C4327488", "aliases": ["down regulation of endosome to plasma membrane protein transport", "down-regulation of endosome to plasma membrane protein transport", "downregulation of endosome to plasma membrane protein transport"], "types": ["T043"], "canonical_name": "negative regulation of endosome to plasma membrane protein transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endosome to plasma membrane protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:22869721]"}
{"concept_id": "C4327489", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endosome to plasma membrane protein transport", "definition": "Any process that modulates the frequency, rate or extent of endosome to plasma membrane protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:22869721]"}
{"concept_id": "C4327490", "aliases": ["palatum durum morphogenesis"], "types": ["T042"], "canonical_name": "hard palate morphogenesis", "definition": "The developmental process by which a hard palate is generated and organized. [GO_REF:0000083, GOC:TermGenie, PMID:23419067]"}
{"concept_id": "C4327491", "aliases": ["down-regulation of salivation", "negative regulation of salivation", "downregulation of saliva secretion", "down regulation of saliva secretion", "downregulation of salivation", "down regulation of salivation", "down-regulation of saliva secretion"], "types": ["T042"], "canonical_name": "negative regulation of saliva secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion. [GO_REF:0000058, GOC:TermGenie, PMID:23419067]"}
{"concept_id": "C4327492", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mRNA cis splicing, via spliceosome", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA cis splicing, via spliceosome. [GO_REF:0000058, GOC:TermGenie, PMID:2880558]"}
{"concept_id": "C4327493", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mRNA cis splicing, via spliceosome", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cis splicing, via spliceosome. [GO_REF:0000058, GOC:TermGenie, PMID:2880558]"}
{"concept_id": "C4327494", "aliases": ["regulation of nuclear mRNA cis splicing, via spliceosome"], "types": ["T045"], "canonical_name": "regulation of mRNA cis splicing, via spliceosome", "definition": "Any process that modulates the frequency, rate or extent of mRNA cis splicing, via spliceosome. [GO_REF:0000058, GOC:TermGenie, PMID:2880558]"}
{"concept_id": "C4327495", "aliases": ["mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration", "calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration"], "types": ["T043"], "canonical_name": "calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration", "definition": "Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration. [GO_REF:0000060, GOC:TermGenie, PMID:26644474]"}
{"concept_id": "C4327496", "aliases": ["mitochondrial calcium release involved in positive regulation of presynaptic cytosolic calcium concentration", "calcium ion transmembrane export from mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration"], "types": ["T043"], "canonical_name": "calcium export from the mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration", "definition": "Any mitochondrial calcium release that is involved in positive regulation of presynaptic cytosolic calcium concentration. [GO_REF:0000060, GOC:TermGenie, PMID:26644474]"}
{"concept_id": "C4327497", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of L-proline import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of L-proline import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:24344203]"}
{"concept_id": "C4327498", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of L-proline import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-proline import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:24344203]"}
{"concept_id": "C4327499", "aliases": [], "types": ["T043"], "canonical_name": "regulation of L-proline import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of L-proline import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:24344203]"}
{"concept_id": "C4327500", "aliases": ["protein localisation to microtubule end"], "types": ["T043"], "canonical_name": "protein localization to microtubule end", "definition": "A process in which a protein is transported to, or maintained in, a location at a microtubule end. [GO_REF:0000087, GOC:TermGenie, PMID:12034771]"}
{"concept_id": "C4327501", "aliases": ["upregulation of trypanothione synthesis", "up-regulation of trypanothione biosynthesis", "up regulation of trypanothione synthesis", "up regulation of trypanothione biosynthetic process", "positive regulation of trypanothione anabolism", "upregulation of trypanothione formation", "positive regulation of trypanothione biosynthesis", "up-regulation of trypanothione formation", "upregulation of trypanothione biosynthetic process", "up-regulation of trypanothione biosynthetic process", "up regulation of trypanothione formation", "positive regulation of trypanothione synthesis", "up-regulation of trypanothione anabolism", "up-regulation of trypanothione synthesis", "positive regulation of trypanothione formation", "upregulation of trypanothione biosynthesis", "up regulation of trypanothione anabolism", "up regulation of trypanothione biosynthesis", "upregulation of trypanothione anabolism"], "types": ["T044"], "canonical_name": "positive regulation of trypanothione biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of trypanothione biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:18949025]"}
{"concept_id": "C4327502", "aliases": ["down regulation of trypanothione synthesis", "negative regulation of trypanothione synthesis", "negative regulation of trypanothione biosynthesis", "down-regulation of trypanothione biosynthetic process", "down regulation of trypanothione formation", "down-regulation of trypanothione anabolism", "downregulation of trypanothione formation", "downregulation of trypanothione synthesis", "negative regulation of trypanothione anabolism", "downregulation of trypanothione biosynthesis", "down regulation of trypanothione biosynthetic process", "down regulation of trypanothione biosynthesis", "downregulation of trypanothione biosynthetic process", "down regulation of trypanothione anabolism", "downregulation of trypanothione anabolism", "down-regulation of trypanothione formation", "down-regulation of trypanothione synthesis", "down-regulation of trypanothione biosynthesis", "negative regulation of trypanothione formation"], "types": ["T044"], "canonical_name": "negative regulation of trypanothione biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of trypanothione biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:18949025]"}
{"concept_id": "C4327503", "aliases": ["regulation of trypanothione biosynthesis", "regulation of trypanothione synthesis", "regulation of trypanothione anabolism", "regulation of trypanothione formation"], "types": ["T044"], "canonical_name": "regulation of trypanothione biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of trypanothione biosynthetic process. [GO_REF:0000058, GOC:TermGenie, PMID:18949025]"}
{"concept_id": "C4327504", "aliases": ["microtubule fascicle of cytoplasm", "microtubule bundle of cytoplasm"], "types": ["T026"], "canonical_name": "cytoplasmic microtubule bundle", "definition": "Any microtubule bundle that is part of a cytoplasm. [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291]"}
{"concept_id": "C4327505", "aliases": ["protein localization to perinuclear cytoplasm", "protein localisation to perinuclear region of cytoplasm", "protein localisation in perinuclear region of cytoplasm", "protein localization in perinuclear region of cytoplasm"], "types": ["T043"], "canonical_name": "protein localization to perinuclear region of cytoplasm", "definition": "A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm. [GO_REF:0000087, GOC:TermGenie, PMID:15177031]"}
{"concept_id": "C4327506", "aliases": ["upregulation of cornification", "up-regulation of cornification", "up regulation of cornification"], "types": ["T043"], "canonical_name": "positive regulation of cornification", "definition": "Any process that activates or increases the frequency, rate or extent of cornification. [GO_REF:0000058, GOC:TermGenie, PMID:26014679]"}
{"concept_id": "C4327507", "aliases": ["downregulation of cornification", "down regulation of cornification", "down-regulation of cornification"], "types": ["T043"], "canonical_name": "negative regulation of cornification", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cornification. [GO_REF:0000058, GOC:TermGenie, PMID:26014679]"}
{"concept_id": "C4327508", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cornification", "definition": "Any process that modulates the frequency, rate or extent of cornification. [GO_REF:0000058, GOC:TermGenie, PMID:26014679]"}
{"concept_id": "C4327509", "aliases": ["cellular response to phosphatidyl(amino)ethanols", "cellular response to phosphatidylethanolamines", "cellular response to PtdEtn", "cellular response to PE"], "types": ["T043"], "canonical_name": "cellular response to phosphatidylethanolamine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:1657995]"}
{"concept_id": "C4327510", "aliases": ["response to phosphatidylethanolamines", "response to PtdEtn", "response to PE", "response to phosphatidyl(amino)ethanols"], "types": ["T043"], "canonical_name": "response to phosphatidylethanolamine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:1657995]"}
{"concept_id": "C4327511", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of membrane permeability", "definition": "Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane. [PMID:27482894]"}
{"concept_id": "C4327512", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of membrane permeability", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the passage or uptake of molecules by a membrane. [PMID:27482894]"}
{"concept_id": "C4327513", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell morphogenesis involved in conjugation with cellular fusion", "definition": "Any process that modulates the location, frequency, rate or extent of cell morphogenesis involved in conjugation with cellular fusion. [GO_REF:0000058, GOC:TermGenie, PMID:23200991]"}
{"concept_id": "C4327514", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial ATP synthesis coupled proton transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport. [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286]"}
{"concept_id": "C4327515", "aliases": [], "types": ["T044"], "canonical_name": "regulation of mitochondrial ATP synthesis coupled proton transport", "definition": "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport. [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286]"}
{"concept_id": "C4327516", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to paclitaxel", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18472094]"}
{"concept_id": "C4327517", "aliases": ["upregulation of inhibitory synapse assembly", "up regulation of inhibitory synapse formation", "up-regulation of inhibitory synapse formation", "up regulation of inhibitory synapse assembly", "upregulation of inhibitory synapse formation", "up-regulation of inhibitory synapse assembly", "positive regulation of inhibitory synapse formation"], "types": ["T043"], "canonical_name": "positive regulation of inhibitory synapse assembly", "definition": "Any process that activates or increases the frequency, rate or extent of inhibitory synapse assembly. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327518", "aliases": ["down regulation of inhibitory synapse formation", "downregulation of inhibitory synapse formation", "negative regulation of inhibitory synapse formation", "down-regulation of inhibitory synapse formation", "down regulation of inhibitory synapse assembly", "down-regulation of inhibitory synapse assembly", "downregulation of inhibitory synapse assembly"], "types": ["T043"], "canonical_name": "negative regulation of inhibitory synapse assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory synapse assembly. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327519", "aliases": ["regulation of inhibitory synapse formation"], "types": ["T043"], "canonical_name": "regulation of inhibitory synapse assembly", "definition": "Any process that modulates the frequency, rate or extent of inhibitory synapse assembly. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]"}
{"concept_id": "C4327520", "aliases": ["up regulation of drug transmembrane export", "up-regulation of drug transmembrane export", "upregulation of drug transmembrane export"], "types": ["T043"], "canonical_name": "positive regulation of drug transmembrane export"}
{"concept_id": "C4327521", "aliases": ["down-regulation of drug transmembrane export", "downregulation of drug transmembrane export", "down regulation of drug transmembrane export"], "types": ["T043"], "canonical_name": "negative regulation of drug transmembrane export"}
{"concept_id": "C4327522", "aliases": [], "types": ["T043"], "canonical_name": "regulation of drug transmembrane export"}
{"concept_id": "C4327523", "aliases": ["upregulation of polyribosome binding", "upregulation of polysome binding", "up regulation of polyribosome binding", "up-regulation of polysome binding", "up-regulation of polyribosome binding", "positive regulation of polyribosome binding", "up regulation of polysome binding"], "types": ["T044"], "canonical_name": "positive regulation of polysome binding", "definition": "Any process that activates or increases the frequency, rate or extent of polysome binding. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]"}
{"concept_id": "C4327524", "aliases": ["down-regulation of polyribosome binding", "down regulation of polysome binding", "downregulation of polysome binding", "down-regulation of polysome binding", "downregulation of polyribosome binding", "negative regulation of polyribosome binding", "down regulation of polyribosome binding"], "types": ["T044"], "canonical_name": "negative regulation of polysome binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of polysome binding. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]"}
{"concept_id": "C4327525", "aliases": ["regulation of polyribosome binding"], "types": ["T044"], "canonical_name": "regulation of polysome binding", "definition": "Any process that modulates the frequency, rate or extent of polysome binding. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]"}
{"concept_id": "C4327526", "aliases": ["up regulation of phosphatidic acid formation", "upregulation of phosphatidic acid formation", "positive regulation of phosphatidic acid synthesis", "up-regulation of phosphatidic acid formation", "positive regulation of phosphatidic acid anabolism", "up regulation of phosphatidic acid anabolism", "upregulation of phosphatidic acid anabolism", "positive regulation of phosphatidic acid formation", "upregulation of phosphatidic acid synthesis", "upregulation of phosphatidic acid biosynthesis", "up regulation of phosphatidic acid biosynthetic process", "up regulation of phosphatidic acid synthesis", "up-regulation of phosphatidic acid synthesis", "up-regulation of phosphatidic acid biosynthesis", "positive regulation of phosphatidic acid biosynthesis", "up-regulation of phosphatidic acid anabolism", "upregulation of phosphatidic acid biosynthetic process", "up regulation of phosphatidic acid biosynthesis", "up-regulation of phosphatidic acid biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of phosphatidic acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidic acid biosynthetic process. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959]"}
{"concept_id": "C4327527", "aliases": ["down-regulation of phosphatidic acid formation", "down regulation of phosphatidic acid anabolism", "down-regulation of phosphatidic acid biosynthetic process", "downregulation of phosphatidic acid anabolism", "downregulation of phosphatidic acid formation", "downregulation of phosphatidic acid synthesis", "down regulation of phosphatidic acid biosynthetic process", "negative regulation of phosphatidic acid biosynthesis", "negative regulation of phosphatidic acid formation", "downregulation of phosphatidic acid biosynthetic process", "down regulation of phosphatidic acid formation", "downregulation of phosphatidic acid biosynthesis", "down regulation of phosphatidic acid synthesis", "down regulation of phosphatidic acid biosynthesis", "down-regulation of phosphatidic acid anabolism", "down-regulation of phosphatidic acid synthesis", "negative regulation of phosphatidic acid anabolism", "down-regulation of phosphatidic acid biosynthesis", "negative regulation of phosphatidic acid synthesis"], "types": ["T044"], "canonical_name": "negative regulation of phosphatidic acid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidic acid biosynthetic process. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959]"}
{"concept_id": "C4327528", "aliases": ["regulation of phosphatidic acid anabolism", "regulation of phosphatidic acid formation", "regulation of phosphatidic acid biosynthesis", "regulation of phosphatidic acid synthesis"], "types": ["T044"], "canonical_name": "regulation of phosphatidic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of phosphatidic acid biosynthetic process. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959]"}
{"concept_id": "C4327529", "aliases": ["ER disassembly"], "types": ["T043"], "canonical_name": "endoplasmic reticulum disassembly", "definition": "The disaggregation of an endoplasmic reticulum into its constituent components. [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C4327530", "aliases": ["adiposome disassembly", "lipid body disassembly", "lipid droplet reserve breakdown", "lipid particle disassembly"], "types": ["T043"], "canonical_name": "lipid droplet disassembly", "definition": "The disaggregation of a lipid particle into its constituent components. [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C4327531", "aliases": ["cell nucleus disassembly"], "types": ["T043"], "canonical_name": "nucleus disassembly", "definition": "The disaggregation of a nucleus into its constituent components. [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C4327532", "aliases": ["up-regulation of diacylglycerol kinase activity", "up regulation of diacylglycerol kinase activity", "positive regulation of sn-1,2-diacylglycerol kinase activity", "upregulation of 1,2-diacylglycerol kinase (phosphorylating)", "upregulation of sn-1,2-diacylglycerol kinase activity", "upregulation of 1,2-diacylglycerol kinase activity", "up regulation of 1,2-diacylglycerol kinase (phosphorylating)", "positive regulation of arachidonoyl-specific diacylglycerol kinase activity", "up regulation of diglyceride kinase activity", "up-regulation of 1,2-diacylglycerol kinase (phosphorylating)", "up-regulation of DGK activity", "positive regulation of 1,2-diacylglycerol kinase activity", "up-regulation of sn-1,2-diacylglycerol kinase activity", "up regulation of 1,2-diacylglycerol kinase activity", "up-regulation of DG kinase activity", "upregulation of diacylglycerol kinase activity", "up regulation of arachidonoyl-specific diacylglycerol kinase activity", "positive regulation of DG kinase activity", "up-regulation of diglyceride kinase activity", "up-regulation of 1,2-diacylglycerol kinase activity", "positive regulation of 1,2-diacylglycerol kinase (phosphorylating)", "upregulation of DG kinase activity", "upregulation of DGK activity", "up-regulation of arachidonoyl-specific diacylglycerol kinase activity", "upregulation of diglyceride kinase activity", "positive regulation of DGK activity", "up regulation of DG kinase activity", "up regulation of DGK activity", "positive regulation of diglyceride kinase activity", "up regulation of sn-1,2-diacylglycerol kinase activity", "upregulation of arachidonoyl-specific diacylglycerol kinase activity"], "types": ["T044"], "canonical_name": "positive regulation of diacylglycerol kinase activity", "definition": "Any process that activates or increases the frequency, rate or extent of diacylglycerol kinase activity. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060]"}
{"concept_id": "C4327533", "aliases": ["downregulation of diacylglycerol kinase activity", "negative regulation of DGK activity", "downregulation of arachidonoyl-specific diacylglycerol kinase activity", "down-regulation of DG kinase activity", "downregulation of DG kinase activity", "down regulation of arachidonoyl-specific diacylglycerol kinase activity", "negative regulation of sn-1,2-diacylglycerol kinase activity", "down regulation of sn-1,2-diacylglycerol kinase activity", "down regulation of DGK activity", "down regulation of DG kinase activity", "down-regulation of 1,2-diacylglycerol kinase activity", "down-regulation of DGK activity", "negative regulation of 1,2-diacylglycerol kinase (phosphorylating)", "down-regulation of diglyceride kinase activity", "negative regulation of arachidonoyl-specific diacylglycerol kinase activity", "downregulation of diglyceride kinase activity", "down-regulation of arachidonoyl-specific diacylglycerol kinase activity", "downregulation of sn-1,2-diacylglycerol kinase activity", "down regulation of diacylglycerol kinase activity", "downregulation of 1,2-diacylglycerol kinase (phosphorylating)", "downregulation of DGK activity", "downregulation of 1,2-diacylglycerol kinase activity", "negative regulation of 1,2-diacylglycerol kinase activity", "down regulation of 1,2-diacylglycerol kinase activity", "down regulation of diglyceride kinase activity", "negative regulation of DG kinase activity", "down regulation of 1,2-diacylglycerol kinase (phosphorylating)", "down-regulation of 1,2-diacylglycerol kinase (phosphorylating)", "down-regulation of sn-1,2-diacylglycerol kinase activity", "down-regulation of diacylglycerol kinase activity", "negative regulation of diglyceride kinase activity"], "types": ["T044"], "canonical_name": "negative regulation of diacylglycerol kinase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol kinase activity. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060]"}
{"concept_id": "C4327534", "aliases": ["regulation of 1,2-diacylglycerol kinase activity", "regulation of 1,2-diacylglycerol kinase (phosphorylating)", "regulation of DG kinase activity", "regulation of DGK activity", "regulation of sn-1,2-diacylglycerol kinase activity", "regulation of diglyceride kinase activity", "regulation of arachidonoyl-specific diacylglycerol kinase activity"], "types": ["T044"], "canonical_name": "regulation of diacylglycerol kinase activity", "definition": "Any process that modulates the frequency, rate or extent of diacylglycerol kinase activity. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060]"}
{"concept_id": "C4327535", "aliases": ["up regulation of plasma membrane repair", "upregulation of plasma membrane repair", "up-regulation of plasma membrane repair"], "types": ["T043"], "canonical_name": "positive regulation of plasma membrane repair", "definition": "Any process that activates or increases the frequency, rate or extent of plasma membrane repair. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]"}
{"concept_id": "C4327536", "aliases": ["downregulation of plasma membrane repair", "down regulation of plasma membrane repair", "down-regulation of plasma membrane repair"], "types": ["T043"], "canonical_name": "negative regulation of plasma membrane repair", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane repair. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]"}
{"concept_id": "C4327537", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plasma membrane repair", "definition": "Any process that modulates the frequency, rate or extent of plasma membrane repair. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]"}
{"concept_id": "C4327538", "aliases": ["up-regulation of innate immunity memory response", "upregulation of innate immunity memory response", "up regulation of innate immunity memory response"], "types": ["T040"], "canonical_name": "positive regulation of innate immunity memory response", "definition": "Any process that activates or increases the frequency, rate or extent of innate immunity memory response. [GO_REF:0000058, GOC:TermGenie]"}
{"concept_id": "C4327539", "aliases": ["down regulation of innate immunity memory response", "down-regulation of innate immunity memory response", "downregulation of innate immunity memory response"], "types": ["T040"], "canonical_name": "negative regulation of innate immunity memory response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of innate immunity memory response. [GO_REF:0000058, GOC:TermGenie]"}
{"concept_id": "C4327540", "aliases": [], "types": ["T040"], "canonical_name": "regulation of innate immunity memory response", "definition": "Any process that modulates the frequency, rate or extent of innate immunity memory response. [GO_REF:0000058, GOC:TermGenie]"}
{"concept_id": "C4327541", "aliases": ["upregulation of adaptive immune effector response", "up regulation of adaptive immune effector response", "up-regulation of adaptive immune effector response"], "types": ["T040"], "canonical_name": "positive regulation of adaptive immune effector response", "definition": "Any process that activates or increases the frequency, rate or extent of adaptive immune effector response. [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833]"}
{"concept_id": "C4327542", "aliases": ["down-regulation of adaptive immune effector response", "downregulation of adaptive immune effector response", "down regulation of adaptive immune effector response"], "types": ["T040"], "canonical_name": "negative regulation of adaptive immune effector response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune effector response. [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833]"}
{"concept_id": "C4327543", "aliases": [], "types": ["T040"], "canonical_name": "regulation of adaptive immune effector response", "definition": "Any process that modulates the frequency, rate or extent of adaptive immune effector response. [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833]"}
{"concept_id": "C4327544", "aliases": ["up-regulation of adaptive immune memory response", "upregulation of adaptive immune memory response", "up regulation of adaptive immune memory response"], "types": ["T040"], "canonical_name": "positive regulation of adaptive immune memory response", "definition": "Any process that activates or increases the frequency, rate or extent of adaptive immune memory response. [GO_REF:0000058, GOC:TermGenie, PMID:26831526]"}
{"concept_id": "C4327545", "aliases": ["down-regulation of adaptive immune memory response", "downregulation of adaptive immune memory response", "down regulation of adaptive immune memory response"], "types": ["T040"], "canonical_name": "negative regulation of adaptive immune memory response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune memory response. [GO_REF:0000058, GOC:TermGenie, PMID:26831526]"}
{"concept_id": "C4327546", "aliases": [], "types": ["T040"], "canonical_name": "regulation of adaptive immune memory response", "definition": "Any process that modulates the frequency, rate or extent of adaptive immune memory response. [GO_REF:0000058, GOC:TermGenie, PMID:26831526]"}
{"concept_id": "C4327547", "aliases": ["upregulation of lysosome organisation", "up regulation of lysosome organization", "up-regulation of lysosome organization", "up-regulation of lysosome organisation", "upregulation of lysosome organization", "up regulation of lysosome organisation", "positive regulation of lysosome organisation"], "types": ["T043"], "canonical_name": "positive regulation of lysosome organization", "definition": "Any process that activates or increases the frequency, rate or extent of lysosome organization. [GO_REF:0000058, GOC:TermGenie, PMID:25561470]"}
{"concept_id": "C4327548", "aliases": ["down-regulation of lysosome organisation", "down regulation of lysosome organisation", "downregulation of lysosome organisation", "down regulation of lysosome organization", "negative regulation of lysosome organisation", "downregulation of lysosome organization", "down-regulation of lysosome organization"], "types": ["T043"], "canonical_name": "negative regulation of lysosome organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization. [GO_REF:0000058, GOC:TermGenie, PMID:25561470]"}
{"concept_id": "C4327549", "aliases": ["regulation of lysosome organisation"], "types": ["T043"], "canonical_name": "regulation of lysosome organization", "definition": "Any process that modulates the frequency, rate or extent of lysosome organization. [GO_REF:0000058, GOC:TermGenie, PMID:25561470]"}
{"concept_id": "C4327550", "aliases": ["TORC2 disassembly", "TOR complex 2 disassembly", "TORC 2 complex disassembly", "rapamycin and nutrient-insensitive TOR complex disassembly"], "types": ["T044"], "canonical_name": "TORC2 complex disassembly", "definition": "The disaggregation of a TORC2 complex into its constituent components. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218]"}
{"concept_id": "C4327551", "aliases": ["TORC1 complex formation", "TORC1 assembly", "nutrient sensitive complex formation", "TORC 1 complex formation", "TOR complex 1 formation", "nutrient sensitive complex assembly", "TORC 1 complex assembly", "rapamycin and nutrient-sensitive TOR complex formation", "TORC1 formation", "TOR complex 1 assembly", "rapamycin and nutrient-sensitive TOR complex assembly"], "types": ["T044"], "canonical_name": "TORC1 complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a TORC1 complex. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218]"}
{"concept_id": "C4327552", "aliases": ["up regulation of protein localisation in endosome", "up regulation of protein localization to endosome", "positive regulation of protein localisation in endosome", "upregulation of protein localization in endosome", "upregulation of protein localisation in endosome", "up regulation of protein localization in endosome", "up-regulation of protein localization to endosome", "upregulation of protein localization to endosome", "up-regulation of protein localization in endosome", "positive regulation of protein localization in endosome", "up-regulation of protein localisation in endosome"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to endosome", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to endosome. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145]"}
{"concept_id": "C4327553", "aliases": ["down-regulation of protein localization in endosome", "negative regulation of protein localization in endosome", "down regulation of protein localization to endosome", "downregulation of protein localization to endosome", "down-regulation of protein localisation in endosome", "negative regulation of protein localisation in endosome", "downregulation of protein localization in endosome", "down regulation of protein localization in endosome", "down regulation of protein localisation in endosome", "downregulation of protein localisation in endosome", "down-regulation of protein localization to endosome"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to endosome", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endosome. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145]"}
{"concept_id": "C4327554", "aliases": ["regulation of protein localisation in endosome", "regulation of protein localization in endosome"], "types": ["T043"], "canonical_name": "regulation of protein localization to endosome", "definition": "Any process that modulates the frequency, rate or extent of protein localization to endosome. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145]"}
{"concept_id": "C4327555", "aliases": ["up regulation of calcium ion import across plasma membrane", "upregulation of calcium ion import across plasma membrane", "up-regulation of calcium ion import across plasma membrane"], "types": ["T043"], "canonical_name": "positive regulation of calcium ion import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]"}
{"concept_id": "C4327556", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium ion import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]"}
{"concept_id": "C4327557", "aliases": ["positive regulation of telomerase, catalyst", "upregulation of telomerase RNA reverse transcriptase activity", "up regulation of telomerase RNA reverse transcriptase activity", "up regulation of telomerase, catalyst", "upregulation of telomerase, catalyst", "up-regulation of telomerase, catalyst", "up-regulation of telomerase RNA reverse transcriptase activity"], "types": ["T044"], "canonical_name": "positive regulation of telomerase RNA reverse transcriptase activity", "definition": "Any process that activates or increases the frequency, rate or extent of telomerase RNA reverse transcriptase activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954]"}
{"concept_id": "C4327558", "aliases": ["down regulation of telomerase RNA reverse transcriptase activity", "down regulation of telomerase, catalyst", "negative regulation of telomerase, catalyst", "downregulation of telomerase RNA reverse transcriptase activity", "down-regulation of telomerase, catalyst", "down-regulation of telomerase RNA reverse transcriptase activity", "downregulation of telomerase, catalyst"], "types": ["T044"], "canonical_name": "negative regulation of telomerase RNA reverse transcriptase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954]"}
{"concept_id": "C4327559", "aliases": ["regulation of telomerase, catalyst"], "types": ["T044"], "canonical_name": "regulation of telomerase RNA reverse transcriptase activity", "definition": "Any process that modulates the frequency, rate or extent of telomerase RNA reverse transcriptase activity. [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954]"}
{"concept_id": "C4327560", "aliases": ["MCC formation", "MCC assembly", "mitotic checkpoint complex formation"], "types": ["T044"], "canonical_name": "mitotic checkpoint complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a mitotic checkpoint complex. [GO_REF:0000079, GOC:TermGenie, PMID:26882497]"}
{"concept_id": "C4327561", "aliases": ["upregulation of artery smooth muscle contraction", "up-regulation of artery smooth muscle contraction", "up regulation of artery smooth muscle contraction"], "types": ["T042"], "canonical_name": "positive regulation of artery smooth muscle contraction", "definition": "Any process that activates or increases the frequency, rate or extent of artery smooth muscle contraction. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]"}
{"concept_id": "C4327562", "aliases": ["downregulation of artery smooth muscle contraction", "down-regulation of artery smooth muscle contraction", "down regulation of artery smooth muscle contraction"], "types": ["T042"], "canonical_name": "negative regulation of artery smooth muscle contraction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of artery smooth muscle contraction. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]"}
{"concept_id": "C4327563", "aliases": [], "types": ["T042"], "canonical_name": "regulation of artery smooth muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of artery smooth muscle contraction. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]"}
{"concept_id": "C4327564", "aliases": ["up-regulation of arteriogenesis", "up regulation of arterial morphogenesis", "up regulation of arteriogenesis", "upregulation of arteriogenesis", "up-regulation of arterial morphogenesis", "upregulation of arterial morphogenesis", "positive regulation of arterial morphogenesis", "up regulation of artery morphogenesis", "positive regulation of arteriogenesis", "up-regulation of artery morphogenesis", "upregulation of artery morphogenesis"], "types": ["T042"], "canonical_name": "positive regulation of artery morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of artery morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]"}
{"concept_id": "C4327565", "aliases": ["down-regulation of arteriogenesis", "negative regulation of arterial morphogenesis", "down-regulation of arterial morphogenesis", "down regulation of arterial morphogenesis", "downregulation of arterial morphogenesis", "down-regulation of artery morphogenesis", "negative regulation of arteriogenesis", "down regulation of arteriogenesis", "downregulation of artery morphogenesis", "down regulation of artery morphogenesis", "downregulation of arteriogenesis"], "types": ["T042"], "canonical_name": "negative regulation of artery morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]"}
{"concept_id": "C4327566", "aliases": ["regulation of arterial morphogenesis", "regulation of arteriogenesis"], "types": ["T042"], "canonical_name": "regulation of artery morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of artery morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]"}
{"concept_id": "C4327567", "aliases": ["upregulation of shell calcification", "up-regulation of shell calcification", "up regulation of shell calcification"], "types": ["T042"], "canonical_name": "positive regulation of shell calcification", "definition": "Any process that activates or increases the frequency, rate or extent of shell calcification. [GO_REF:0000058, GOC:TermGenie, PMID:14648763]"}
{"concept_id": "C4327568", "aliases": ["down regulation of shell calcification", "down-regulation of shell calcification", "downregulation of shell calcification"], "types": ["T042"], "canonical_name": "negative regulation of shell calcification", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of shell calcification. [GO_REF:0000058, GOC:TermGenie, PMID:14648763]"}
{"concept_id": "C4327569", "aliases": [], "types": ["T042"], "canonical_name": "regulation of shell calcification", "definition": "Any process that modulates the frequency, rate or extent of shell calcification. [GO_REF:0000058, GOC:TermGenie, PMID:14648763]"}
{"concept_id": "C4327570", "aliases": ["up regulation of Facilitates chromatin transcription complex formation", "up-regulation of Facilitates chromatin transcription complex assembly", "up-regulation of Facilitates chromatin transcription complex formation", "up-regulation of FACT complex assembly", "up regulation of FACT complex assembly", "upregulation of Facilitates chromatin transcription complex assembly", "upregulation of FACT complex assembly", "up regulation of Facilitates chromatin transcription complex assembly", "upregulation of Facilitates chromatin transcription complex formation", "up-regulation of FACT complex formation", "up regulation of FACT complex formation", "positive regulation of FACT complex formation", "positive regulation of Facilitates chromatin transcription complex assembly", "positive regulation of Facilitates chromatin transcription complex formation", "upregulation of FACT complex formation"], "types": ["T043"], "canonical_name": "positive regulation of FACT complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of FACT complex assembly. [GO_REF:0000058, GOC:TermGenie, PMID:20889714]"}
{"concept_id": "C4327571", "aliases": ["downregulation of FACT complex assembly", "down regulation of Facilitates chromatin transcription complex assembly", "down-regulation of Facilitates chromatin transcription complex formation", "down-regulation of Facilitates chromatin transcription complex assembly", "down-regulation of FACT complex assembly", "down regulation of FACT complex assembly", "down regulation of Facilitates chromatin transcription complex formation", "downregulation of Facilitates chromatin transcription complex formation", "negative regulation of FACT complex formation", "negative regulation of Facilitates chromatin transcription complex assembly", "down regulation of FACT complex formation", "downregulation of FACT complex formation", "negative regulation of Facilitates chromatin transcription complex formation", "downregulation of Facilitates chromatin transcription complex assembly", "down-regulation of FACT complex formation"], "types": ["T043"], "canonical_name": "negative regulation of FACT complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of FACT complex assembly. [GO_REF:0000058, GOC:TermGenie, PMID:20889714]"}
{"concept_id": "C4327572", "aliases": ["regulation of Facilitates chromatin transcription complex formation", "regulation of FACT complex formation", "regulation of Facilitates chromatin transcription complex assembly"], "types": ["T043"], "canonical_name": "regulation of FACT complex assembly", "definition": "Any process that modulates the frequency, rate or extent of FACT complex assembly. [GO_REF:0000058, GOC:TermGenie, PMID:20889714]"}
{"concept_id": "C4327573", "aliases": ["upregulation of DNA methylation", "up-regulation of DNA methylation", "up regulation of DNA methylation"], "types": ["T044"], "canonical_name": "positive regulation of DNA methylation", "definition": "Any process that activates or increases the frequency, rate or extent of DNA methylation. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847]"}
{"concept_id": "C4327574", "aliases": ["down-regulation of DNA methylation", "down regulation of DNA methylation", "downregulation of DNA methylation"], "types": ["T044"], "canonical_name": "negative regulation of DNA methylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA methylation. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847]"}
{"concept_id": "C4327575", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to acetaldehyde", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:27687866]"}
{"concept_id": "C4327576", "aliases": [], "types": ["T043"], "canonical_name": "response to acetaldehyde", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:27687866]"}
{"concept_id": "C4327577", "aliases": ["up regulation of mitochondrial mRNA catabolic process", "up-regulation of mitochondrial mRNA catabolic process", "upregulation of mitochondrial mRNA catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of mitochondrial mRNA catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of mitochondrial mRNA catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:27122350]"}
{"concept_id": "C4327578", "aliases": ["down-regulation of mitochondrial mRNA catabolic process", "downregulation of mitochondrial mRNA catabolic process", "down regulation of mitochondrial mRNA catabolic process"], "types": ["T044"], "canonical_name": "negative regulation of mitochondrial mRNA catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial mRNA catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:27122350]"}
{"concept_id": "C4327579", "aliases": [], "types": ["T044"], "canonical_name": "regulation of mitochondrial mRNA catabolic process", "definition": "Any process that modulates the frequency, rate or extent of mitochondrial mRNA catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:27122350]"}
{"concept_id": "C4327580", "aliases": ["up regulation of RNA polymerase II regulatory region sequence-specific DNA binding", "up-regulation of RNA polymerase II regulatory region sequence-specific DNA binding", "upregulation of RNA polymerase II regulatory region sequence-specific DNA binding"], "types": ["T045"], "canonical_name": "positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding", "definition": "Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23675531]"}
{"concept_id": "C4327581", "aliases": ["Facilitates chromatin transcription complex assembly", "Facilitates chromatin transcription complex formation", "FACT complex formation"], "types": ["T044"], "canonical_name": "FACT complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a FACT complex. [GO_REF:0000079, GOC:TermGenie, PMID:20889714]"}
{"concept_id": "C4327582", "aliases": ["regulation of protein localisation to chromatin"], "types": ["T043"], "canonical_name": "regulation of protein localization to chromatin", "definition": "Any process that modulates the frequency, rate or extent of protein localization to chromatin. [GO_REF:0000058, GOC:TermGenie, PMID:20889714]"}
{"concept_id": "C4327583", "aliases": ["establishment of protein localisation to euchromatin", "establishment of protein localization in euchromatin", "establishment of protein localisation in euchromatin"], "types": ["T043"], "canonical_name": "establishment of protein localization to euchromatin", "definition": "The directed movement of a protein to a specific location in an euchromatin. [GO_REF:0000087, GOC:TermGenie, PMID:20889714]"}
{"concept_id": "C4327584", "aliases": ["protein localisation to euchromatin", "protein localization in euchromatin", "protein localisation in euchromatin"], "types": ["T043"], "canonical_name": "protein localization to euchromatin", "definition": "A process in which a protein is transported to, or maintained in, a location within an euchromatin. [GO_REF:0000087, GOC:TermGenie, PMID:20889714]"}
{"concept_id": "C4327585", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to glyceraldehyde", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:11377826]"}
{"concept_id": "C4327586", "aliases": [], "types": ["T043"], "canonical_name": "response to glyceraldehyde", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:11377826]"}
{"concept_id": "C4327587", "aliases": ["upregulation of serotonin formation", "up regulation of serotonin anabolism", "up-regulation of serotonin biosynthetic process", "positive regulation of serotonin formation", "upregulation of serotonin biosynthesis", "up regulation of serotonin biosynthesis", "upregulation of serotonin biosynthetic process", "up-regulation of serotonin synthesis", "upregulation of serotonin anabolism", "positive regulation of serotonin biosynthesis", "up-regulation of serotonin biosynthesis", "upregulation of serotonin synthesis", "up-regulation of serotonin formation", "up regulation of serotonin biosynthetic process", "up-regulation of serotonin anabolism", "positive regulation of serotonin anabolism", "up regulation of serotonin synthesis", "positive regulation of serotonin synthesis", "up regulation of serotonin formation"], "types": ["T044"], "canonical_name": "positive regulation of serotonin biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]"}
{"concept_id": "C4327588", "aliases": ["downregulation of serotonin formation", "negative regulation of serotonin anabolism", "down-regulation of serotonin biosynthetic process", "downregulation of serotonin biosynthetic process", "down-regulation of serotonin biosynthesis", "downregulation of serotonin biosynthesis", "down-regulation of serotonin anabolism", "down regulation of serotonin synthesis", "down regulation of serotonin biosynthesis", "negative regulation of serotonin formation", "down regulation of serotonin anabolism", "down regulation of serotonin biosynthetic process", "negative regulation of serotonin synthesis", "down-regulation of serotonin synthesis", "downregulation of serotonin synthesis", "down regulation of serotonin formation", "down-regulation of serotonin formation", "negative regulation of serotonin biosynthesis", "downregulation of serotonin anabolism"], "types": ["T043"], "canonical_name": "negative regulation of serotonin biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]"}
{"concept_id": "C4327589", "aliases": ["regulation of serotonin biosynthesis", "regulation of serotonin synthesis", "regulation of serotonin formation", "regulation of serotonin anabolism"], "types": ["T043"], "canonical_name": "regulation of serotonin biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]"}
{"concept_id": "C4327590", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of L-methionine import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of L-methionine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:17556368]"}
{"concept_id": "C4327591", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of L-methionine import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-methionine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:17556368]"}
{"concept_id": "C4327592", "aliases": [], "types": ["T043"], "canonical_name": "regulation of L-methionine import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of L-methionine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:17556368]"}
{"concept_id": "C4327593", "aliases": ["up regulation of leaf development", "upregulation of leaf development", "up-regulation of leaf development"], "types": ["T039"], "canonical_name": "positive regulation of leaf development", "definition": "Any process that activates or increases the frequency, rate or extent of leaf development. [GO_REF:0000058, GOC:TermGenie, PMID:11606552]"}
{"concept_id": "C4327594", "aliases": ["down regulation of leaf development", "down-regulation of leaf development", "downregulation of leaf development"], "types": ["T039"], "canonical_name": "negative regulation of leaf development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leaf development. [GO_REF:0000058, GOC:TermGenie, PMID:11606552]"}
{"concept_id": "C4327595", "aliases": ["positive regulation of alpha-1,3-fucosyltransferase activity", "upregulation of alpha-1,3-fucosyltransferase activity", "up-regulation of alpha-(1,3)-fucosyltransferase activity", "up-regulation of alpha-(1->3)-fucosyltransferase activity", "up regulation of alpha-(1,3)-fucosyltransferase activity", "upregulation of alpha-(1->3)-fucosyltransferase activity", "upregulation of alpha(1,3)-fucosyltransferase activity", "up-regulation of alpha(1,3)-fucosyltransferase activity", "up-regulation of alpha-1,3-fucosyltransferase activity", "upregulation of alpha-(1,3)-fucosyltransferase activity", "positive regulation of alpha(1,3)-fucosyltransferase activity", "positive regulation of alpha-(1,3)-fucosyltransferase activity", "up regulation of alpha(1,3)-fucosyltransferase activity", "up regulation of alpha-1,3-fucosyltransferase activity", "up regulation of alpha-(1->3)-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "positive regulation of alpha-(1->3)-fucosyltransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity. [GO_REF:0000059, GOC:TermGenie, PMID:15364955]"}
{"concept_id": "C4327596", "aliases": ["down regulation of alpha(1,3)-fucosyltransferase activity", "down-regulation of alpha(1,3)-fucosyltransferase activity", "down-regulation of alpha-(1,3)-fucosyltransferase activity", "down regulation of alpha-(1,3)-fucosyltransferase activity", "downregulation of alpha(1,3)-fucosyltransferase activity", "downregulation of alpha-(1->3)-fucosyltransferase activity", "negative regulation of alpha-1,3-fucosyltransferase activity", "down-regulation of alpha-1,3-fucosyltransferase activity", "down-regulation of alpha-(1->3)-fucosyltransferase activity", "downregulation of alpha-(1,3)-fucosyltransferase activity", "negative regulation of alpha-(1,3)-fucosyltransferase activity", "downregulation of alpha-1,3-fucosyltransferase activity", "down regulation of alpha-1,3-fucosyltransferase activity", "negative regulation of alpha(1,3)-fucosyltransferase activity", "down regulation of alpha-(1->3)-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "negative regulation of alpha-(1->3)-fucosyltransferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity. [GO_REF:0000059, GOC:TermGenie, PMID:15364955]"}
{"concept_id": "C4327597", "aliases": ["regulation of alpha-(1,3)-fucosyltransferase activity", "regulation of alpha(1,3)-fucosyltransferase activity", "regulation of alpha-1,3-fucosyltransferase activity"], "types": ["T044"], "canonical_name": "regulation of alpha-(1->3)-fucosyltransferase activity", "definition": "Any process that modulates the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity. [GO_REF:0000059, GOC:TermGenie, PMID:15364955]"}
{"concept_id": "C4327601", "aliases": ["upregulation of developmental vegetative growth", "up-regulation of developmental vegetative growth", "up regulation of developmental vegetative growth"], "types": ["T040"], "canonical_name": "positive regulation of developmental vegetative growth", "definition": "Any process that activates or increases the frequency, rate or extent of developmental vegetative growth. [GO_REF:0000058, GOC:TermGenie, PMID:11606552]"}
{"concept_id": "C4327602", "aliases": ["down-regulation of developmental vegetative growth", "down regulation of developmental vegetative growth", "downregulation of developmental vegetative growth"], "types": ["T040"], "canonical_name": "negative regulation of developmental vegetative growth", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of developmental vegetative growth. [GO_REF:0000058, GOC:TermGenie, PMID:11606552]"}
{"concept_id": "C4327603", "aliases": [], "types": ["T040"], "canonical_name": "regulation of developmental vegetative growth", "definition": "Any process that modulates the frequency, rate or extent of developmental vegetative growth. [GO_REF:0000058, GOC:TermGenie, PMID:11606552]"}
{"concept_id": "C4327604", "aliases": ["up-regulation of mRNA cap binding", "upregulation of mRNA cap binding", "up regulation of mRNA cap binding"], "types": ["T045"], "canonical_name": "positive regulation of mRNA cap binding", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA cap binding. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]"}
{"concept_id": "C4327605", "aliases": ["down-regulation of mRNA cap binding", "downregulation of mRNA cap binding", "down regulation of mRNA cap binding"], "types": ["T044"], "canonical_name": "negative regulation of mRNA cap binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cap binding. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]"}
{"concept_id": "C4327606", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA cap binding", "definition": "Any process that modulates the frequency, rate or extent of mRNA cap binding. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]"}
{"concept_id": "C4327607", "aliases": ["upregulation of smooth muscle cell-matrix adhesion", "up-regulation of smooth muscle cell-matrix adhesion", "up regulation of smooth muscle cell-matrix adhesion"], "types": ["T043"], "canonical_name": "positive regulation of smooth muscle cell-matrix adhesion", "definition": "Any process that activates or increases the frequency, rate or extent of smooth muscle cell-matrix adhesion. [GO_REF:0000058, GOC:TermGenie, PMID:14970114]"}
{"concept_id": "C4327608", "aliases": ["upregulation of presynapse assembly", "up regulation of presynaptic terminal assembly", "upregulation of presynaptic terminal assembly", "positive regulation of presynaptic terminal assembly", "up-regulation of presynaptic terminal assembly", "positive regulation of presynapse biogenesis", "up regulation of presynapse assembly", "up-regulation of presynapse biogenesis", "up-regulation of presynapse assembly", "up regulation of presynapse biogenesis", "upregulation of presynapse biogenesis"], "types": ["T043"], "canonical_name": "positive regulation of presynapse assembly", "definition": "Any process that activates or increases the frequency, rate or extent of presynapse assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]"}
{"concept_id": "C4327609", "aliases": ["negative regulation of presynapse biogenesis", "downregulation of presynapse assembly", "downregulation of presynaptic terminal assembly", "down regulation of presynapse assembly", "down regulation of presynaptic terminal assembly", "downregulation of presynapse biogenesis", "negative regulation of presynaptic terminal assembly", "down-regulation of presynaptic terminal assembly", "down regulation of presynapse biogenesis", "down-regulation of presynapse biogenesis", "down-regulation of presynapse assembly"], "types": ["T043"], "canonical_name": "negative regulation of presynapse assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]"}
{"concept_id": "C4327610", "aliases": ["regulation of presynapse biogenesis", "regulation of presynaptic terminal assembly"], "types": ["T043"], "canonical_name": "regulation of presynapse assembly", "definition": "Any process that modulates the frequency, rate or extent of presynapse assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]"}
{"concept_id": "C4327611", "aliases": ["positive regulation of blood/brain barrier permeability", "up-regulation of blood/brain barrier permeability", "upregulation of blood/brain barrier permeability", "positive regulation of BBB permeability", "upregulation of BBB permeability", "upregulation of blood-brain barrier permeability", "up-regulation of BBB permeability", "up-regulation of blood-brain barrier permeability"], "types": ["T039"], "canonical_name": "positive regulation of blood-brain barrier permeability", "definition": "Any process that increases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653]"}
{"concept_id": "C4327612", "aliases": ["downregulation of blood-brain barrier permeability", "downregulation of BBB permeability", "down-regulation of BBB permeability", "negative regulation of blood/brain barrier permeability", "negative regulation of BBB permeability", "down-regulation of blood-brain barrier permeability", "down-regulation of blood/brain barrier permeability", "downregulation of blood/brain barrier permeability"], "types": ["T039"], "canonical_name": "negative regulation of blood-brain barrier permeability", "definition": "Any process that decreases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653]"}
{"concept_id": "C4327613", "aliases": ["regulation of BBB permeability", "regulation of blood/brain barrier permeability"], "types": ["T042"], "canonical_name": "regulation of blood-brain barrier permeability", "definition": "Any process that modulates blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653]"}
{"concept_id": "C4327614", "aliases": ["upregulation of receptor-mediated endocytosis involved in cholesterol transport", "up-regulation of receptor-mediated endocytosis involved in cholesterol transport", "up regulation of receptor-mediated endocytosis involved in cholesterol transport"], "types": ["T043"], "canonical_name": "positive regulation of receptor-mediated endocytosis involved in cholesterol transport", "definition": "Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4327615", "aliases": ["down regulation of receptor-mediated endocytosis involved in cholesterol transport", "down-regulation of receptor-mediated endocytosis involved in cholesterol transport", "downregulation of receptor-mediated endocytosis involved in cholesterol transport"], "types": ["T043"], "canonical_name": "negative regulation of receptor-mediated endocytosis involved in cholesterol transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4327616", "aliases": [], "types": ["T043"], "canonical_name": "regulation of receptor-mediated endocytosis involved in cholesterol transport", "definition": "Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4327617", "aliases": ["up regulation of LDLR activity", "upregulation of LDLR activity", "positive regulation of LDLR activity", "up-regulation of LDLR activity", "up-regulation of low-density lipoprotein receptor activity", "upregulation of low-density lipoprotein receptor activity", "positive regulation of LDL receptor", "up regulation of LDL receptor", "upregulation of LDL receptor", "up regulation of low-density lipoprotein receptor activity", "up-regulation of LDL receptor"], "types": ["T043"], "canonical_name": "positive regulation of low-density lipoprotein receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein receptor activity. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4327618", "aliases": ["negative regulation of LDL receptor", "down regulation of low-density lipoprotein receptor activity", "down-regulation of low-density lipoprotein receptor activity", "down regulation of LDL receptor", "down-regulation of LDL receptor", "down regulation of LDLR activity", "downregulation of low-density lipoprotein receptor activity", "downregulation of LDL receptor", "downregulation of LDLR activity", "negative regulation of LDLR activity", "down-regulation of LDLR activity"], "types": ["T044"], "canonical_name": "negative regulation of low-density lipoprotein receptor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4327619", "aliases": ["up regulation of LDL receptor binding", "upregulation of low-density lipoprotein particle receptor binding", "positive regulation of LDL receptor binding", "upregulation of low-density lipoprotein receptor binding", "up regulation of low-density lipoprotein receptor binding", "positive regulation of low-density lipoprotein receptor binding", "upregulation of LDL receptor binding", "up-regulation of LDL receptor binding", "up-regulation of low-density lipoprotein particle receptor binding", "up-regulation of low-density lipoprotein receptor binding", "up regulation of low-density lipoprotein particle receptor binding"], "types": ["T044"], "canonical_name": "positive regulation of low-density lipoprotein particle receptor binding", "definition": "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle receptor binding. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4327620", "aliases": ["down-regulation of low-density lipoprotein receptor binding", "negative regulation of low-density lipoprotein receptor binding", "downregulation of low-density lipoprotein receptor binding", "down regulation of low-density lipoprotein particle receptor binding", "downregulation of low-density lipoprotein particle receptor binding", "downregulation of LDL receptor binding", "down-regulation of low-density lipoprotein particle receptor binding", "down regulation of LDL receptor binding", "down regulation of low-density lipoprotein receptor binding", "down-regulation of LDL receptor binding", "negative regulation of LDL receptor binding"], "types": ["T044"], "canonical_name": "negative regulation of low-density lipoprotein particle receptor binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein particle receptor binding. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4327621", "aliases": ["regulation of LDL receptor binding", "regulation of low-density lipoprotein receptor binding"], "types": ["T043"], "canonical_name": "regulation of low-density lipoprotein particle receptor binding", "definition": "Any process that modulates the frequency, rate or extent of low-density lipoprotein particle receptor binding. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4327622", "aliases": [], "types": ["T044"], "canonical_name": "resveratrol binding", "definition": "Binding to resveratrol. [GO_REF:0000067, GOC:TermGenie, PMID:18254726]"}
{"concept_id": "C4327623", "aliases": ["upregulation of optical nerve axon regeneration", "up regulation of optical nerve axon regeneration", "up-regulation of optical nerve axon regeneration"], "types": ["T043"], "canonical_name": "positive regulation of optical nerve axon regeneration", "definition": "Any process that activates or increases the frequency, rate or extent of optical nerve axon regeneration. [GO_REF:0000058, GOC:TermGenie, PMID:16699509]"}
{"concept_id": "C4327624", "aliases": ["down regulation of optical nerve axon regeneration", "downregulation of optical nerve axon regeneration", "down-regulation of optical nerve axon regeneration"], "types": ["T043"], "canonical_name": "negative regulation of optical nerve axon regeneration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of optical nerve axon regeneration. [GO_REF:0000058, GOC:TermGenie, PMID:16699509]"}
{"concept_id": "C4327625", "aliases": [], "types": ["T043"], "canonical_name": "regulation of optical nerve axon regeneration", "definition": "Any process that modulates the frequency, rate or extent of optical nerve axon regeneration. [GO_REF:0000058, GOC:TermGenie, PMID:16699509]"}
{"concept_id": "C4327626", "aliases": [], "types": ["T043"], "canonical_name": "fibronectin fibril organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril. [GOC:dph, GOC:TermGenie, PMID:20690820]"}
{"concept_id": "C4327627", "aliases": ["cellulose and pectin-containing cell wall modification involved in stomatal movement"], "types": ["T043"], "canonical_name": "plant-type cell wall modification involved in stomatal movement", "definition": "Any plant-type cell wall modification that is involved in stomatal movement. [GO_REF:0000060, GOC:TermGenie, PMID:27720618]"}
{"concept_id": "C4327628", "aliases": ["up-regulation of outer hair cell apoptotic process", "up-regulation of cochlear outer hair cell apoptotic process", "positive regulation of cochlear outer hair cell apoptotic process", "upregulation of outer hair cell apoptotic process", "upregulation of cochlear outer hair cell apoptotic process", "up regulation of outer hair cell apoptotic process", "up regulation of cochlear outer hair cell apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of outer hair cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of outer hair cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24472721]"}
{"concept_id": "C4327629", "aliases": ["down regulation of outer hair cell apoptotic process", "down-regulation of outer hair cell apoptotic process", "downregulation of outer hair cell apoptotic process", "down-regulation of cochlear outer hair cell apoptotic process", "negative regulation of cochlear outer hair cell apoptotic process", "downregulation of cochlear outer hair cell apoptotic process", "down regulation of cochlear outer hair cell apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of outer hair cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of outer hair cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24472721]"}
{"concept_id": "C4327630", "aliases": ["regulation of cochlear outer hair cell apoptotic process"], "types": ["T043"], "canonical_name": "regulation of outer hair cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of outer hair cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24472721]"}
{"concept_id": "C4327631", "aliases": ["cochlear outer hair cell apoptotic process"], "types": ["T043"], "canonical_name": "outer hair cell apoptotic process", "definition": "Any apoptotic process in an outer hair cell. [GO_REF:0000085, GOC:TermGenie, PMID:12062759, PMID:24472721]"}
{"concept_id": "C4327632", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to mannose", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16699509]"}
{"concept_id": "C4327633", "aliases": [], "types": ["T040"], "canonical_name": "response to mannose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16699509]"}
{"concept_id": "C4327634", "aliases": ["upregulation of LDL clearance", "positive regulation of LDL clearance", "up-regulation of low-density lipoprotein particle clearance", "up-regulation of LDL clearance", "up regulation of low-density lipoprotein particle clearance", "upregulation of low-density lipoprotein particle clearance", "up regulation of LDL clearance"], "types": ["T043"], "canonical_name": "positive regulation of low-density lipoprotein particle clearance", "definition": "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle clearance. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]"}
{"concept_id": "C4327635", "aliases": ["up regulation of ERBB3 signalling pathway", "positive regulation of ERBB3 signalling pathway", "up-regulation of HER3 signaling pathway", "upregulation of HER3 signaling pathway", "up regulation of ERBB3 signaling pathway", "positive regulation of HER3 signaling pathway", "upregulation of ERBB3 signalling pathway", "upregulation of ERBB3 signaling pathway", "upregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway", "up-regulation of ERBB3 signalling pathway", "up-regulation of ERBB3 signaling pathway", "positive regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway", "up regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway", "up regulation of HER3 signaling pathway", "up-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway"], "types": ["T043"], "canonical_name": "positive regulation of ERBB3 signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of ERBB3 signaling pathway. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365]"}
{"concept_id": "C4327636", "aliases": ["down regulation of ERBB3 signalling pathway", "downregulation of HER3 signaling pathway", "downregulation of ERBB3 signaling pathway", "negative regulation of ERBB3 signalling pathway", "downregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway", "down regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway", "down regulation of ERBB3 signaling pathway", "negative regulation of HER3 signaling pathway", "down-regulation of ERBB3 signalling pathway", "down regulation of HER3 signaling pathway", "down-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway", "down-regulation of ERBB3 signaling pathway", "negative regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway", "downregulation of ERBB3 signalling pathway", "down-regulation of HER3 signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of ERBB3 signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB3 signaling pathway. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365]"}
{"concept_id": "C4327637", "aliases": ["regulation of HER3 signaling pathway", "regulation of ERBB3 signalling pathway", "regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway"], "types": ["T043"], "canonical_name": "regulation of ERBB3 signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of ERBB3 signaling pathway. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365]"}
{"concept_id": "C4327638", "aliases": [], "types": ["T044"], "canonical_name": "ganglioside GP1c binding", "definition": "Binding to ganglioside GP1c. [GO_REF:0000067, GOC:TermGenie, PMID:1454804]"}
{"concept_id": "C4327639", "aliases": [], "types": ["T044"], "canonical_name": "ganglioside GT1b binding", "definition": "Binding to ganglioside GT1b. [GO_REF:0000067, GOC:TermGenie, PMID:1454804]"}
{"concept_id": "C4327640", "aliases": [], "types": ["T044"], "canonical_name": "ganglioside GM3 binding", "definition": "Binding to ganglioside GM3. [GO_REF:0000067, GOC:TermGenie, PMID:1454804]"}
{"concept_id": "C4327641", "aliases": [], "types": ["T044"], "canonical_name": "ganglioside GM2 binding", "definition": "Binding to ganglioside GM2. [GO_REF:0000067, GOC:TermGenie, PMID:1454804]"}
{"concept_id": "C4327642", "aliases": [], "types": ["T044"], "canonical_name": "ganglioside GM1 binding", "definition": "Binding to ganglioside GM1. [GO_REF:0000067, GOC:TermGenie, PMID:1454804]"}
{"concept_id": "C4327643", "aliases": [], "types": ["T043"], "canonical_name": "ganglioside GM1 transport to membrane", "definition": "The directed movement of ganglioside GM1 to membrane. [GO_REF:0000078, GOC:TermGenie, PMID:1454804]"}
{"concept_id": "C4327644", "aliases": ["up regulation of ferrichrome formation", "upregulation of ferrichrome synthesis", "up regulation of ferrichrome anabolism", "up-regulation of ferrichrome synthesis", "upregulation of ferrichrome biosynthesis", "upregulation of ferrichrome anabolism", "positive regulation of ferrichrome anabolism", "upregulation of ferrichrome biosynthetic process", "positive regulation of ferrichrome biosynthesis", "up-regulation of ferrichrome biosynthesis", "up regulation of ferrichrome synthesis", "up regulation of ferrichrome biosynthesis", "up-regulation of ferrichrome anabolism", "up regulation of ferrichrome biosynthetic process", "positive regulation of ferrichrome synthesis", "upregulation of ferrichrome formation", "positive regulation of ferrichrome formation", "up-regulation of ferrichrome formation", "up-regulation of ferrichrome biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of ferrichrome biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of ferrichrome biosynthetic process. [GO_REF:0000058, GOC:al, GOC:TermGenie, PMID:654321]"}
{"concept_id": "C4327645", "aliases": ["negative regulation of ferrichrome formation", "down regulation of ferrichrome formation", "down regulation of ferrichrome anabolism", "down-regulation of ferrichrome anabolism", "downregulation of ferrichrome anabolism", "down regulation of ferrichrome biosynthetic process", "down regulation of ferrichrome biosynthesis", "negative regulation of ferrichrome biosynthesis", "down-regulation of ferrichrome biosynthesis", "down-regulation of ferrichrome formation", "negative regulation of ferrichrome synthesis", "downregulation of ferrichrome synthesis", "downregulation of ferrichrome biosynthetic process", "downregulation of ferrichrome formation", "downregulation of ferrichrome biosynthesis", "negative regulation of ferrichrome anabolism", "down-regulation of ferrichrome synthesis", "down-regulation of ferrichrome biosynthetic process", "down regulation of ferrichrome synthesis"], "types": ["T043"], "canonical_name": "negative regulation of ferrichrome biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ferrichrome biosynthetic process. [GO_REF:0000058, GOC:al, GOC:TermGenie, PMID:654321]"}
{"concept_id": "C4327646", "aliases": ["regulation of ferrichrome synthesis", "regulation of ferrichrome anabolism", "regulation of ferrichrome formation", "regulation of ferrichrome biosynthesis"], "types": ["T043"], "canonical_name": "regulation of ferrichrome biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of ferrichrome biosynthetic process. [GO_REF:0000058, GOC:al, GOC:TermGenie]"}
{"concept_id": "C4327647", "aliases": ["upregulation of vascular endothelial cell proliferation", "up regulation of vascular endothelial cell proliferation", "up-regulation of vascular endothelial cell proliferation"], "types": ["T043"], "canonical_name": "positive regulation of vascular endothelial cell proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]"}
{"concept_id": "C4327648", "aliases": ["down regulation of vascular endothelial cell proliferation", "downregulation of vascular endothelial cell proliferation", "down-regulation of vascular endothelial cell proliferation"], "types": ["T043"], "canonical_name": "negative regulation of vascular endothelial cell proliferation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]"}
{"concept_id": "C4327649", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vascular endothelial cell proliferation", "definition": "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]"}
{"concept_id": "C4327650", "aliases": ["up regulation of kinetochore assembly", "up-regulation of kinetochore assembly", "upregulation of kinetochore assembly"], "types": ["T043"], "canonical_name": "positive regulation of kinetochore assembly", "definition": "Any process that activates or increases the frequency, rate or extent of kinetochore assembly. [GO_REF:0000058, GOC:TermGenie, PMID:18765790]"}
{"concept_id": "C4327651", "aliases": ["down regulation of kinetochore assembly", "down regulation of kinetochore biogenesis", "down-regulation of kinetochore assembly", "downregulation of kinetochore assembly"], "types": ["T043"], "canonical_name": "negative regulation of kinetochore assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of kinetochore assembly. [GO_REF:0000058, GOC:TermGenie, PMID:18765790]"}
{"concept_id": "C4327652", "aliases": ["up-regulation of mitotic nuclear envelope degradation", "upregulation of mitotic nuclear envelope breakdown", "upregulation of mitotic nuclear envelope catabolism", "positive regulation of mitotic nuclear envelope breakdown", "positive regulation of mitotic nuclear envelope degradation", "up-regulation of mitotic nuclear envelope disassembly", "up regulation of mitotic nuclear envelope degradation", "upregulation of mitotic nuclear envelope disassembly", "upregulation of mitotic nuclear envelope degradation", "up-regulation of mitotic nuclear envelope catabolism", "up regulation of mitotic nuclear envelope catabolism", "up regulation of mitotic nuclear envelope breakdown", "positive regulation of mitotic nuclear envelope catabolism", "up-regulation of mitotic nuclear envelope breakdown", "up regulation of mitotic nuclear envelope disassembly"], "types": ["T043"], "canonical_name": "positive regulation of mitotic nuclear envelope disassembly", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. [GO_REF:0000058, GOC:TermGenie, PMID:18765790]"}
{"concept_id": "C4327653", "aliases": ["down-regulation of mitotic nuclear envelope disassembly", "down regulation of mitotic nuclear envelope catabolism", "down-regulation of mitotic nuclear envelope degradation", "negative regulation of mitotic nuclear envelope degradation", "down-regulation of mitotic nuclear envelope catabolism", "negative regulation of mitotic nuclear envelope catabolism", "downregulation of mitotic nuclear envelope degradation", "down regulation of mitotic nuclear envelope degradation", "downregulation of mitotic nuclear envelope breakdown", "down regulation of mitotic nuclear envelope disassembly", "down-regulation of mitotic nuclear envelope breakdown", "negative regulation of mitotic nuclear envelope breakdown", "downregulation of mitotic nuclear envelope disassembly", "downregulation of mitotic nuclear envelope catabolism", "down regulation of mitotic nuclear envelope breakdown"], "types": ["T043"], "canonical_name": "negative regulation of mitotic nuclear envelope disassembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly. [GO_REF:0000058, GOC:TermGenie, PMID:18765790]"}
{"concept_id": "C4327654", "aliases": ["regulation of mitotic nuclear envelope breakdown", "regulation of mitotic nuclear envelope catabolism", "regulation of mitotic nuclear envelope degradation"], "types": ["T043"], "canonical_name": "regulation of mitotic nuclear envelope disassembly", "definition": "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. [GO_REF:0000058, GOC:TermGenie, PMID:18765790]"}
{"concept_id": "C4327655", "aliases": ["primary ciliary vesicle formation", "ciliary vesicle formation", "primary ciliary vesicle assembly"], "types": ["T043"], "canonical_name": "ciliary vesicle assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a ciliary vesicle. Multiple smaller vesicles dock to the transitional fibers on a mature basal body and then fuse together to form a larger single vesicle. This then fuses with the plasma membrane and forms the ciliary membrane. [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:13978319, PMID:25313408, PMID:25805133, PMID:25812525]"}
{"concept_id": "C4327656", "aliases": ["positive regulation of branching involved in blood vessel morphogenesis", "up-regulation of patterning of blood vessels", "upregulation of branching involved in blood vessel morphogenesis", "up regulation of branching involved in blood vessel morphogenesis", "upregulation of patterning of blood vessels", "up regulation of patterning of blood vessels", "up-regulation of branching involved in blood vessel morphogenesis"], "types": ["T042"], "canonical_name": "positive regulation of blood vessel branching", "definition": "Any process that activates or increases the frequency, rate or extent of blood vessel branching. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]"}
{"concept_id": "C4327657", "aliases": ["downregulation of branching involved in blood vessel morphogenesis", "down-regulation of branching involved in blood vessel morphogenesis", "down regulation of branching involved in blood vessel morphogenesis", "down regulation of patterning of blood vessels", "downregulation of patterning of blood vessels", "negative regulation of branching involved in blood vessel morphogenesis", "down-regulation of patterning of blood vessels"], "types": ["T042"], "canonical_name": "negative regulation of vessel branching", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]"}
{"concept_id": "C4327658", "aliases": ["regulation of branching involved in blood vessel morphogenesis"], "types": ["T042"], "canonical_name": "regulation of blood vessel branching", "definition": "Any process that modulates the frequency, rate or extent of blood vessel branching. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]"}
{"concept_id": "C4327659", "aliases": ["upregulation of protein localization in ER", "positive regulation of protein localisation in endoplasmic reticulum", "up regulation of protein localization in endoplasmic reticulum", "up regulation of protein localization to endoplasmic reticulum", "up-regulation of protein localization in ER", "up regulation of protein localization in ER", "upregulation of protein localization in endoplasmic reticulum", "up-regulation of protein localization in endoplasmic reticulum", "up-regulation of protein localization to endoplasmic reticulum", "up regulation of protein localisation in endoplasmic reticulum", "upregulation of protein localization to endoplasmic reticulum", "positive regulation of protein localization in ER", "positive regulation of protein localization in endoplasmic reticulum", "upregulation of protein localisation in endoplasmic reticulum", "up-regulation of protein localisation in endoplasmic reticulum"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to endoplasmic reticulum", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to endoplasmic reticulum. [GO_REF:0000058, GOC:TermGenie, PMID:22768340]"}
{"concept_id": "C4327660", "aliases": ["down-regulation of protein localization in ER", "negative regulation of protein localization in ER", "negative regulation of protein localization in endoplasmic reticulum", "downregulation of protein localization to endoplasmic reticulum", "negative regulation of protein localisation in endoplasmic reticulum", "down regulation of protein localization in ER", "down regulation of protein localisation in endoplasmic reticulum", "down regulation of protein localization to endoplasmic reticulum", "down-regulation of protein localization in endoplasmic reticulum", "down-regulation of protein localisation in endoplasmic reticulum", "downregulation of protein localisation in endoplasmic reticulum", "down-regulation of protein localization to endoplasmic reticulum", "downregulation of protein localization in endoplasmic reticulum", "down regulation of protein localization in endoplasmic reticulum", "downregulation of protein localization in ER"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to endoplasmic reticulum", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endoplasmic reticulum. [GO_REF:0000058, GOC:TermGenie, PMID:22768340]"}
{"concept_id": "C4327661", "aliases": ["regulation of protein localization in endoplasmic reticulum", "regulation of protein localization in ER", "regulation of protein localisation in endoplasmic reticulum"], "types": ["T043"], "canonical_name": "regulation of protein localization to endoplasmic reticulum", "definition": "Any process that modulates the frequency, rate or extent of protein localization to endoplasmic reticulum. [GO_REF:0000058, GOC:TermGenie, PMID:22768340]"}
{"concept_id": "C4327665", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to phenylpropanoid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylpropanoid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22700048]"}
{"concept_id": "C4327666", "aliases": ["regulation of postsynaptic signaling to nucleus"], "types": ["T043"], "canonical_name": "regulation of postsynapse to nucleus signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway. [GO_REF:0000058, GOC:TermGenie, ISBN:9780071120005]"}
{"concept_id": "C4327667", "aliases": ["polyribosome binding"], "types": ["T044"], "canonical_name": "polysome binding", "definition": "Binding to a polysome. [GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]"}
{"concept_id": "C4327668", "aliases": ["upregulation of eIF4F assembly", "up regulation of eukaryotic translation initiation factor 4F complex assembly", "upregulation of eIF-4F assembly", "upregulation of eukaryotic translation initiation factor 4F complex assembly", "up regulation of eIF4F assembly", "up-regulation of eIF4F assembly", "up-regulation of eIF-4F assembly", "up-regulation of eukaryotic translation initiation factor 4F complex assembly", "positive regulation of eIF4F assembly", "positive regulation of eIF-4F assembly", "up regulation of eIF-4F assembly"], "types": ["T043"], "canonical_name": "positive regulation of eukaryotic translation initiation factor 4F complex assembly", "definition": "Any process that activates or increases the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]"}
{"concept_id": "C4327669", "aliases": ["downregulation of eIF-4F assembly", "negative regulation of eIF-4F assembly", "down-regulation of eIF4F assembly", "downregulation of eukaryotic translation initiation factor 4F complex assembly", "down regulation of eIF-4F assembly", "down-regulation of eIF-4F assembly", "negative regulation of eIF4F assembly", "down-regulation of eukaryotic translation initiation factor 4F complex assembly", "down regulation of eIF4F assembly", "downregulation of eIF4F assembly", "down regulation of eukaryotic translation initiation factor 4F complex assembly"], "types": ["T043"], "canonical_name": "negative regulation of eukaryotic translation initiation factor 4F complex assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]"}
{"concept_id": "C4327670", "aliases": ["regulation of eIF-4F assembly", "regulation of eIF4F assembly"], "types": ["T043"], "canonical_name": "regulation of eukaryotic translation initiation factor 4F complex assembly", "definition": "Any process that modulates the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977]"}
{"concept_id": "C4327671", "aliases": ["up-regulation of leucine import into cell", "positive regulation of leucine import into cell", "up regulation of leucine import into cell", "upregulation of leucine import into cell"], "types": ["T043"], "canonical_name": "positive regulation of leucine import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of leucine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:10467003]"}
{"concept_id": "C4327672", "aliases": ["negative regulation of leucine import into cell", "downregulation of leucine import into cell", "down regulation of leucine import into cell", "down-regulation of leucine import into cell"], "types": ["T043"], "canonical_name": "negative regulation of leucine import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of leucine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:10467003]"}
{"concept_id": "C4327673", "aliases": ["regulation of leucine import into cell"], "types": ["T043"], "canonical_name": "regulation of leucine import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of leucine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:10467003]"}
{"concept_id": "C4327674", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of uracil import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of uracil import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:26536126]"}
{"concept_id": "C4327675", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of uracil import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of uracil import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:26536126]"}
{"concept_id": "C4327676", "aliases": [], "types": ["T043"], "canonical_name": "regulation of uracil import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of uracil import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:26536126]"}
{"concept_id": "C4327677", "aliases": ["upregulation of Golgi lumen acidification", "up regulation of Golgi lumen acidification", "up-regulation of Golgi lumen acidification"], "types": ["T043"], "canonical_name": "positive regulation of Golgi lumen acidification", "definition": "Any process that activates or increases the frequency, rate or extent of Golgi lumen acidification. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592]"}
{"concept_id": "C4327678", "aliases": ["down-regulation of Golgi lumen acidification", "down regulation of Golgi lumen acidification", "downregulation of Golgi lumen acidification"], "types": ["T043"], "canonical_name": "negative regulation of Golgi lumen acidification", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Golgi lumen acidification. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592]"}
{"concept_id": "C4327679", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Golgi lumen acidification", "definition": "Any process that modulates the frequency, rate or extent of Golgi lumen acidification. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592]"}
{"concept_id": "C4327680", "aliases": ["downregulation of protein self-ubiquitination", "downregulation of protein auto-ubiquitination", "downregulation of protein auto-ubiquitinylation", "down regulation of protein self-ubiquitinylation", "down regulation of protein autoubiquitination", "down-regulation of protein auto-ubiquitinylation", "negative regulation of protein autoubiquitinylation", "down regulation of protein auto-ubiquitination", "negative regulation of protein auto-ubiquitination", "negative regulation of protein self-ubiquitination", "down regulation of protein self-ubiquitination", "down-regulation of protein auto-ubiquitination", "negative regulation of protein auto-ubiquitinylation", "down regulation of protein auto-ubiquitinylation", "negative regulation of protein self-ubiquitinylation", "down-regulation of protein autoubiquitinylation", "down-regulation of protein self-ubiquitinylation", "downregulation of protein autoubiquitination", "downregulation of protein autoubiquitinylation", "down-regulation of protein autoubiquitination", "down regulation of protein autoubiquitinylation", "down-regulation of protein self-ubiquitination", "downregulation of protein self-ubiquitinylation"], "types": ["T043"], "canonical_name": "negative regulation of protein autoubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:17237821]"}
{"concept_id": "C4327681", "aliases": ["up-regulation of macrophage migration", "upregulation of macrophage migration", "up regulation of macrophage migration"], "types": ["T043"], "canonical_name": "positive regulation of macrophage migration", "definition": "Any process that activates or increases the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]"}
{"concept_id": "C4327682", "aliases": ["down regulation of macrophage migration", "downregulation of macrophage migration", "down-regulation of macrophage migration"], "types": ["T043"], "canonical_name": "negative regulation of macrophage migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]"}
{"concept_id": "C4327683", "aliases": [], "types": ["T043"], "canonical_name": "regulation of macrophage migration", "definition": "Any process that modulates the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]"}
{"concept_id": "C4327684", "aliases": ["positive regulation of pre-synaptic active zone assembly", "upregulation of presynaptic active zone formation", "positive regulation of presynaptic active zone formation", "up-regulation of pre-synaptic active zone assembly", "up-regulation of presynaptic active zone assembly", "upregulation of presynaptic active zone assembly", "up regulation of presynaptic active zone formation", "up regulation of presynaptic active zone assembly", "upregulation of pre-synaptic active zone formation", "up regulation of pre-synaptic active zone formation", "up-regulation of presynaptic active zone formation", "up-regulation of pre-synaptic active zone formation", "up regulation of pre-synaptic active zone assembly", "positive regulation of pre-synaptic active zone formation", "upregulation of pre-synaptic active zone assembly"], "types": ["T043"], "canonical_name": "positive regulation of presynaptic active zone assembly", "definition": "Any process that activates or increases the frequency, rate or extent of presynaptic active zone assembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875]"}
{"concept_id": "C4327685", "aliases": ["down regulation of presynaptic active zone formation", "down-regulation of presynaptic active zone assembly", "downregulation of pre-synaptic active zone formation", "down-regulation of presynaptic active zone formation", "downregulation of presynaptic active zone assembly", "negative regulation of pre-synaptic active zone formation", "downregulation of pre-synaptic active zone assembly", "down-regulation of pre-synaptic active zone assembly", "negative regulation of presynaptic active zone formation", "down regulation of pre-synaptic active zone assembly", "downregulation of presynaptic active zone formation", "negative regulation of pre-synaptic active zone assembly", "down regulation of pre-synaptic active zone formation", "down regulation of presynaptic active zone assembly", "down-regulation of pre-synaptic active zone formation"], "types": ["T043"], "canonical_name": "negative regulation of presynaptic active zone assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic active zone assembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875]"}
{"concept_id": "C4327686", "aliases": ["regulation of presynaptic active zone formation", "regulation of pre-synaptic active zone assembly", "regulation of pre-synaptic active zone formation"], "types": ["T043"], "canonical_name": "regulation of presynaptic active zone assembly", "definition": "Any process that modulates the frequency, rate or extent of presynaptic active zone assembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875]"}
{"concept_id": "C4327687", "aliases": [], "types": ["T043"], "canonical_name": "macrophage migration", "definition": "The orderly movement of a macrophage from one site to another. [GO_REF:0000091, GOC:TermGenie, PMID:25749876]"}
{"concept_id": "C4327688", "aliases": ["positive regulation of syngamy", "up regulation of fertilization", "up-regulation of fertilization", "up regulation of syngamy", "up-regulation of syngamy", "upregulation of fertilization", "upregulation of syngamy"], "types": ["T040"], "canonical_name": "positive regulation of fertilization", "definition": "Any process that activates or increases the frequency, rate or extent of fertilization. [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576]"}
{"concept_id": "C4327689", "aliases": ["non-motile cilium formation", "nonmotile cilium formation", "nonmotile cilium assembly"], "types": ["T043"], "canonical_name": "non-motile cilium assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium. [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]"}
{"concept_id": "C4327690", "aliases": ["upregulation of synaptic facilitation", "up-regulation of synaptic facilitation", "up regulation of synaptic facilitation", "up-regulation of short-term synaptic potentiation", "upregulation of short-term synaptic potentiation", "positive regulation of synaptic facilitation", "up regulation of short-term synaptic potentiation"], "types": ["T043"], "canonical_name": "positive regulation of short-term synaptic potentiation", "definition": "Any process that activates or increases the frequency, rate or extent of short-term synaptic potentiation. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145]"}
{"concept_id": "C4327691", "aliases": ["down-regulation of synaptic facilitation", "down regulation of short-term synaptic potentiation", "downregulation of synaptic facilitation", "negative regulation of synaptic facilitation", "down-regulation of short-term synaptic potentiation", "downregulation of short-term synaptic potentiation", "down regulation of synaptic facilitation"], "types": ["T043"], "canonical_name": "negative regulation of short-term synaptic potentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of short-term synaptic potentiation. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145]"}
{"concept_id": "C4327692", "aliases": ["regulation of synaptic facilitation"], "types": ["T043"], "canonical_name": "regulation of short-term synaptic potentiation", "definition": "Any process that modulates the frequency, rate or extent of short-term synaptic potentiation. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145]"}
{"concept_id": "C4327693", "aliases": ["up-regulation of myosin II filament assembly", "upregulation of myosin II filament assembly", "up regulation of myosin II filament assembly"], "types": ["T043"], "canonical_name": "positive regulation of myosin II filament assembly", "definition": "Any process that activates or increases the frequency, rate or extent of myosin II filament assembly. [GO_REF:0000058, GOC:TermGenie, PMID:27237792, PMID:7691416]"}
{"concept_id": "C4327694", "aliases": ["down regulation of myosin II filament assembly", "downregulation of myosin II filament assembly", "down-regulation of myosin II filament assembly"], "types": ["T043"], "canonical_name": "negative regulation of myosin II filament assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament assembly. [GO_REF:0000058, GOC:TermGenie, PMID:27237792, PMID:7691416]"}
{"concept_id": "C4327695", "aliases": ["protein localisation to interphase microtubule organizing center", "protein localisation in interphase microtubule organizing center", "protein localization in interphase microtubule organizing center"], "types": ["T043"], "canonical_name": "protein localization to interphase microtubule organizing center", "definition": "A process in which a protein is transported to, or maintained in, a location within an interphase microtubule organizing center. [GO_REF:0000087, GOC:TermGenie, PMID:19001497]"}
{"concept_id": "C4327696", "aliases": ["protein localization in microtubule organizing center", "protein localisation in microtubule organizing center", "protein localisation to microtubule organizing center"], "types": ["T043"], "canonical_name": "protein localization to microtubule organizing center", "definition": "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center. [GO_REF:0000087, GOC:TermGenie, PMID:19001497]"}
{"concept_id": "C4327698", "aliases": [], "types": ["T026"], "canonical_name": "gerontoplast stroma", "definition": "Any plastid stroma that is part of a gerontoplast. [GO_REF:0000064, GOC:mag, GOC:TermGenie, PMID:11212360]"}
{"concept_id": "C4327699", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of motile cilium assembly", "definition": "Any process that activates or increases the frequency, rate or extent of motile cilium assembly. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]"}
{"concept_id": "C4327700", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of motile cilium assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]"}
{"concept_id": "C4327701", "aliases": [], "types": ["T043"], "canonical_name": "regulation of motile cilium assembly", "definition": "Any process that modulates the frequency, rate or extent of motile cilium assembly. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]"}
{"concept_id": "C4327702", "aliases": ["acetyl-coenzyme A binding"], "types": ["T044"], "canonical_name": "acetyl-CoA binding", "definition": "Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component. [GO_REF:0000067, GOC:bc, GOC:krc, GOC:PARL, GOC:TermGenie, PMID:24927529]"}
{"concept_id": "C4327703", "aliases": [], "types": ["T043"], "canonical_name": "trichome papilla formation", "definition": "The aggregation, arrangement and bonding together of a set of components to form a trichome papilla. [GO_REF:0000079, GOC:tb, GOC:TermGenie, PMID:24014871]"}
{"concept_id": "C4327704", "aliases": ["up regulation of triplex DNA binding", "up-regulation of triplex DNA binding", "upregulation of triplex DNA binding"], "types": ["T045"], "canonical_name": "positive regulation of triplex DNA binding", "definition": "Any process that activates or increases the frequency, rate or extent of triplex DNA binding. [GO_REF:0000059, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327705", "aliases": ["down-regulation of triplex DNA binding", "down regulation of triplex DNA binding", "downregulation of triplex DNA binding"], "types": ["T045"], "canonical_name": "negative regulation of triplex DNA binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of triplex DNA binding. [GO_REF:0000059, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327706", "aliases": [], "types": ["T045"], "canonical_name": "regulation of triplex DNA binding", "definition": "Any process that modulates the frequency, rate or extent of triplex DNA binding. [GO_REF:0000059, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327707", "aliases": ["up regulation of quadruplex DNA binding", "positive regulation of tetraplex DNA binding", "positive regulation of G quartet DNA binding", "up regulation of G-DNA binding", "upregulation of G-quartet DNA binding", "up-regulation of tetraplex DNA binding", "up regulation of G quartet DNA binding", "upregulation of tetraplex DNA binding", "up regulation of G quadruplex DNA binding", "up-regulation of G quadruplex DNA binding", "positive regulation of G quadruplex DNA binding", "upregulation of G-DNA binding", "positive regulation of quadruplex DNA binding", "up regulation of tetraplex DNA binding", "up-regulation of G quartet DNA binding", "positive regulation of G-quartet DNA binding", "up-regulation of G-quartet DNA binding", "upregulation of G quartet DNA binding", "upregulation of G-quadruplex DNA binding", "up regulation of G-quartet DNA binding", "upregulation of quadruplex DNA binding", "up-regulation of quadruplex DNA binding", "up regulation of G-quadruplex DNA binding", "up-regulation of G-DNA binding", "positive regulation of G-DNA binding", "upregulation of G quadruplex DNA binding", "up-regulation of G-quadruplex DNA binding"], "types": ["T045"], "canonical_name": "positive regulation of G-quadruplex DNA binding", "definition": "Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA binding. [GO_REF:0000059, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327708", "aliases": ["down-regulation of G quadruplex DNA binding", "down regulation of G quartet DNA binding", "negative regulation of tetraplex DNA binding", "down regulation of tetraplex DNA binding", "down regulation of G quadruplex DNA binding", "downregulation of G-quartet DNA binding", "down regulation of G-quadruplex DNA binding", "down-regulation of G-DNA binding", "downregulation of G quadruplex DNA binding", "down-regulation of G-quartet DNA binding", "negative regulation of G-DNA binding", "down-regulation of quadruplex DNA binding", "negative regulation of G quadruplex DNA binding", "down regulation of quadruplex DNA binding", "downregulation of G-quadruplex DNA binding", "downregulation of tetraplex DNA binding", "negative regulation of quadruplex DNA binding", "down-regulation of tetraplex DNA binding", "down regulation of G-quartet DNA binding", "downregulation of G quartet DNA binding", "down-regulation of G-quadruplex DNA binding", "downregulation of quadruplex DNA binding", "negative regulation of G-quartet DNA binding", "downregulation of G-DNA binding", "down-regulation of G quartet DNA binding", "negative regulation of G quartet DNA binding", "down regulation of G-DNA binding"], "types": ["T045"], "canonical_name": "negative regulation of G-quadruplex DNA binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA binding. [GO_REF:0000059, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327709", "aliases": ["up-regulation of branching morphogenesis of a nerve", "up regulation of branching morphogenesis of a nerve", "upregulation of branching morphogenesis of a nerve"], "types": ["T042"], "canonical_name": "positive regulation of branching morphogenesis of a nerve", "definition": "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327710", "aliases": ["up regulation of sensory neuron axon guidance", "upregulation of sensory neuron axon guidance", "up-regulation of sensory neuron axon guidance"], "types": ["T043"], "canonical_name": "positive regulation of sensory neuron axon guidance", "definition": "Any process that activates or increases the frequency, rate or extent of sensory neuron axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327711", "aliases": ["downregulation of sensory neuron axon guidance", "down regulation of sensory neuron axon guidance", "down-regulation of sensory neuron axon guidance"], "types": ["T043"], "canonical_name": "negative regulation of sensory neuron axon guidance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of sensory neuron axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327712", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sensory neuron axon guidance", "definition": "Any process that modulates the frequency, rate or extent of sensory neuron axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327713", "aliases": ["up-regulation of anterior-posterior axon guidance", "up regulation of anterior-posterior axon guidance", "upregulation of anterior-posterior axon guidance", "up regulation of anterior/posterior axon pathfinding", "up regulation of anterior/posterior axon guidance", "upregulation of anterior/posterior axon pathfinding", "positive regulation of anterior/posterior axon pathfinding", "up-regulation of anterior/posterior axon guidance", "up-regulation of anterior/posterior axon pathfinding", "upregulation of anterior/posterior axon guidance", "positive regulation of anterior-posterior axon guidance"], "types": ["T043"], "canonical_name": "positive regulation of anterior/posterior axon guidance", "definition": "Any process that activates or increases the frequency, rate or extent of anterior/posterior axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327714", "aliases": ["down regulation of anterior/posterior axon pathfinding", "negative regulation of anterior-posterior axon guidance", "down regulation of anterior-posterior axon guidance", "down-regulation of anterior/posterior axon guidance", "negative regulation of anterior/posterior axon pathfinding", "downregulation of anterior/posterior axon pathfinding", "downregulation of anterior-posterior axon guidance", "downregulation of anterior/posterior axon guidance", "down regulation of anterior/posterior axon guidance", "down-regulation of anterior/posterior axon pathfinding", "down-regulation of anterior-posterior axon guidance"], "types": ["T043"], "canonical_name": "negative regulation of anterior/posterior axon guidance", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of anterior/posterior axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327715", "aliases": ["regulation of anterior/posterior axon pathfinding", "regulation of anterior-posterior axon guidance"], "types": ["T043"], "canonical_name": "regulation of anterior/posterior axon guidance", "definition": "Any process that modulates the frequency, rate or extent of anterior/posterior axon guidance. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327716", "aliases": ["upregulation of motor neuron migration", "up regulation of motor neuron migration", "up-regulation of motor neuron migration"], "types": ["T043"], "canonical_name": "positive regulation of motor neuron migration", "definition": "Any process that activates or increases the frequency, rate or extent of motor neuron migration. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327717", "aliases": ["down-regulation of motor neuron migration", "down regulation of motor neuron migration", "downregulation of motor neuron migration"], "types": ["T043"], "canonical_name": "negative regulation of motor neuron migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327718", "aliases": [], "types": ["T043"], "canonical_name": "regulation of motor neuron migration", "definition": "Any process that modulates the frequency, rate or extent of motor neuron migration. [GO_REF:0000058, GOC:TermGenie, PMID:16516839]"}
{"concept_id": "C4327721", "aliases": ["upregulation of glutamylhydroxamic synthetase activity", "up regulation of glutamine synthetase activity", "positive regulation of L-glutamate:ammonia ligase (ADP-forming)", "up regulation of L-glutamine synthetase activity", "up-regulation of L-glutamate:ammonia ligase (ADP-forming)", "up-regulation of glutamylhydroxamic synthetase activity", "up-regulation of glutamate-ammonia ligase activity", "upregulation of glutamine synthetase activity", "up regulation of glutamate-ammonia ligase activity", "up regulation of glutamylhydroxamic synthetase activity", "up-regulation of glutamine synthetase activity", "upregulation of L-glutamate:ammonia ligase (ADP-forming)", "positive regulation of glutamylhydroxamic synthetase activity", "positive regulation of L-glutamine synthetase activity", "up-regulation of L-glutamine synthetase activity", "positive regulation of glutamine synthetase activity", "upregulation of L-glutamine synthetase activity", "upregulation of glutamate-ammonia ligase activity", "up regulation of L-glutamate:ammonia ligase (ADP-forming)"], "types": ["T044"], "canonical_name": "positive regulation of glutamate-ammonia ligase activity", "definition": "Any process that activates or increases the frequency, rate or extent of glutamate-ammonia ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:10377385]"}
{"concept_id": "C4327722", "aliases": ["down regulation of glutamine synthetase activity", "down-regulation of glutamylhydroxamic synthetase activity", "negative regulation of L-glutamate:ammonia ligase (ADP-forming)", "negative regulation of glutamine synthetase activity", "downregulation of L-glutamine synthetase activity", "downregulation of L-glutamate:ammonia ligase (ADP-forming)", "down-regulation of L-glutamine synthetase activity", "down regulation of glutamate-ammonia ligase activity", "negative regulation of L-glutamine synthetase activity", "down-regulation of glutamine synthetase activity", "negative regulation of glutamylhydroxamic synthetase activity", "downregulation of glutamylhydroxamic synthetase activity", "down regulation of glutamylhydroxamic synthetase activity", "down regulation of L-glutamate:ammonia ligase (ADP-forming)", "down regulation of L-glutamine synthetase activity", "down-regulation of L-glutamate:ammonia ligase (ADP-forming)", "downregulation of glutamate-ammonia ligase activity", "down-regulation of glutamate-ammonia ligase activity", "downregulation of glutamine synthetase activity"], "types": ["T044"], "canonical_name": "negative regulation of glutamate-ammonia ligase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate-ammonia ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:10377385]"}
{"concept_id": "C4327723", "aliases": ["regulation of glutamylhydroxamic synthetase activity", "regulation of glutamine synthetase activity", "regulation of L-glutamine synthetase activity", "regulation of L-glutamate:ammonia ligase (ADP-forming)"], "types": ["T044"], "canonical_name": "regulation of glutamate-ammonia ligase activity", "definition": "Any process that modulates the frequency, rate or extent of glutamate-ammonia ligase activity. [GO_REF:0000059, GOC:TermGenie, PMID:10377385]"}
{"concept_id": "C4327724", "aliases": ["upregulation of protein localization to membrane", "positive regulation of protein localization in membrane", "up regulation of protein localisation in membrane", "up-regulation of protein localisation in membrane", "up regulation of protein localization to membrane", "up-regulation of protein localization to membrane", "upregulation of protein localization in membrane", "up-regulation of protein localization in membrane", "up regulation of protein localization in membrane", "upregulation of protein localisation in membrane", "positive regulation of protein localisation in membrane"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to membrane", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to membrane. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]"}
{"concept_id": "C4327725", "aliases": ["down-regulation of protein localization in membrane", "downregulation of protein localisation in membrane", "down regulation of protein localisation in membrane", "negative regulation of protein localisation in membrane", "downregulation of protein localization to membrane", "down regulation of protein localization in membrane", "down regulation of protein localization to membrane", "down-regulation of protein localization to membrane", "down-regulation of protein localisation in membrane", "downregulation of protein localization in membrane", "negative regulation of protein localization in membrane"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]"}
{"concept_id": "C4327726", "aliases": ["regulation of protein localization in membrane", "regulation of protein localisation in membrane"], "types": ["T043"], "canonical_name": "regulation of protein localization to membrane", "definition": "Any process that modulates the frequency, rate or extent of protein localization to membrane. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]"}
{"concept_id": "C4327727", "aliases": ["Wnt receptor signalling pathway through beta-catenin involved in stem cell proliferation", "Wnt receptor signaling pathway through beta-catenin involved in stem cell proliferation", "Wnt receptor signaling pathway via beta-catenin involved in stem cell proliferation", "canonical Wnt-activated signaling pathway involved in stem cell proliferation", "canonical Wnt receptor signaling pathway involved in stem cell proliferation"], "types": ["T043"], "canonical_name": "canonical Wnt signaling pathway involved in stem cell proliferation", "definition": "Any canonical Wnt signaling pathway that is involved in stem cell proliferation. [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183]"}
{"concept_id": "C4327728", "aliases": ["up-regulation of histone H3-K79 dimethylation", "up-regulation of histone lysine H3 K79 dimethylation", "up-regulation of histone H3 K79 dimethylation", "upregulation of histone lysine H3 K79 dimethylation", "up regulation of histone H3 K79 dimethylation", "up regulation of histone H3-K79 dimethylation", "upregulation of histone H3 K79 dimethylation", "upregulation of histone H3-K79 dimethylation", "up regulation of histone lysine H3 K79 dimethylation", "positive regulation of histone H3 K79 dimethylation", "positive regulation of histone lysine H3 K79 dimethylation"], "types": ["T043"], "canonical_name": "positive regulation of histone H3-K79 dimethylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K79 dimethylation. [GO_REF:0000058, GOC:TermGenie, PMID:27541139]"}
{"concept_id": "C4327729", "aliases": ["negative regulation of histone H3 K79 dimethylation", "down regulation of histone H3-K79 dimethylation", "downregulation of histone H3 K79 dimethylation", "down-regulation of histone H3 K79 dimethylation", "negative regulation of histone lysine H3 K79 dimethylation", "downregulation of histone lysine H3 K79 dimethylation", "down-regulation of histone lysine H3 K79 dimethylation", "down regulation of histone lysine H3 K79 dimethylation", "down-regulation of histone H3-K79 dimethylation", "downregulation of histone H3-K79 dimethylation", "down regulation of histone H3 K79 dimethylation"], "types": ["T043"], "canonical_name": "negative regulation of histone H3-K79 dimethylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 dimethylation. [GO_REF:0000058, GOC:TermGenie, PMID:27541139]"}
{"concept_id": "C4327730", "aliases": ["regulation of histone H3 K79 dimethylation", "regulation of histone lysine H3 K79 dimethylation"], "types": ["T043"], "canonical_name": "regulation of histone H3-K79 dimethylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K79 dimethylation. [GO_REF:0000058, GOC:TermGenie, PMID:27541139]"}
{"concept_id": "C4327731", "aliases": ["positive regulation of coated pit assembly", "up-regulation of coated pit formation", "up-regulation of clathrin-coated pit formation", "up-regulation of coated pit assembly", "up regulation of clathrin-coated pit assembly", "positive regulation of clathrin-coated pit formation", "upregulation of clathrin-coated pit formation", "upregulation of clathrin-coated pit assembly", "up-regulation of clathrin-coated pit assembly", "up regulation of coated pit formation", "up regulation of coated pit assembly", "upregulation of coated pit assembly", "up regulation of clathrin-coated pit formation", "upregulation of coated pit formation", "positive regulation of coated pit formation"], "types": ["T043"], "canonical_name": "positive regulation of clathrin-coated pit assembly", "definition": "Any process that activates or increases the frequency, rate or extent of clathrin-coated pit assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327732", "aliases": ["down regulation of coated pit formation", "negative regulation of coated pit assembly", "down regulation of clathrin-coated pit assembly", "downregulation of clathrin-coated pit assembly", "down-regulation of coated pit assembly", "down regulation of coated pit assembly", "negative regulation of coated pit formation", "downregulation of clathrin-coated pit formation", "downregulation of coated pit assembly", "down-regulation of clathrin-coated pit formation", "negative regulation of clathrin-coated pit formation", "downregulation of coated pit formation", "down-regulation of clathrin-coated pit assembly", "down regulation of clathrin-coated pit formation", "down-regulation of coated pit formation"], "types": ["T043"], "canonical_name": "negative regulation of clathrin-coated pit assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-coated pit assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]"}
{"concept_id": "C4327733", "aliases": ["regulation of coated pit formation", "regulation of coated pit assembly", "regulation of clathrin-coated pit formation"], "types": ["T043"], "canonical_name": "regulation of clathrin-coated pit assembly", "definition": "Any process that modulates the frequency, rate or extent of clathrin-coated pit assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327734", "aliases": ["up regulation of G-quadruplex DNA unwinding", "upregulation of G-quadruplex DNA unwinding", "up-regulation of G-quadruplex DNA unwinding"], "types": ["T045"], "canonical_name": "positive regulation of G-quadruplex DNA unwinding", "definition": "Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA unwinding. [GO_REF:0000058, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327735", "aliases": ["downregulation of G-quadruplex DNA unwinding", "down-regulation of G-quadruplex DNA unwinding", "down regulation of G-quadruplex DNA unwinding"], "types": ["T045"], "canonical_name": "negative regulation of G-quadruplex DNA unwinding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA unwinding. [GO_REF:0000058, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327736", "aliases": [], "types": ["T045"], "canonical_name": "regulation of G-quadruplex DNA unwinding", "definition": "Any process that modulates the frequency, rate or extent of G-quadruplex DNA unwinding. [GO_REF:0000058, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327737", "aliases": ["positive regulation of duplex DNA melting", "up regulation of DNA duplex unwinding", "up regulation of duplex DNA melting", "up-regulation of DNA unwinding", "upregulation of DNA unwinding", "up regulation of DNA unwinding", "up-regulation of DNA duplex unwinding", "upregulation of duplex DNA melting", "positive regulation of DNA unwinding", "upregulation of DNA duplex unwinding", "up-regulation of duplex DNA melting"], "types": ["T045"], "canonical_name": "positive regulation of DNA duplex unwinding", "definition": "Any process that activates or increases the frequency, rate or extent of DNA duplex unwinding. [GO_REF:0000058, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327738", "aliases": ["down-regulation of DNA unwinding", "down regulation of duplex DNA melting", "downregulation of duplex DNA melting", "down-regulation of duplex DNA melting", "down regulation of DNA duplex unwinding", "negative regulation of DNA unwinding", "down regulation of DNA unwinding", "downregulation of DNA unwinding", "down-regulation of DNA duplex unwinding", "negative regulation of duplex DNA melting", "downregulation of DNA duplex unwinding"], "types": ["T045"], "canonical_name": "negative regulation of DNA duplex unwinding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA duplex unwinding. [GO_REF:0000058, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327739", "aliases": ["regulation of duplex DNA melting", "regulation of DNA unwinding"], "types": ["T045"], "canonical_name": "regulation of DNA duplex unwinding", "definition": "Any process that modulates the frequency, rate or extent of DNA duplex unwinding. [GO_REF:0000058, GOC:TermGenie, PMID:26503245]"}
{"concept_id": "C4327740", "aliases": ["upregulation of vascular smooth muscle cell apoptotic process", "upregulation of VSMC apoptotic process", "up-regulation of VSMC apoptotic process", "up-regulation of vascular smooth muscle cell apoptotic process", "positive regulation of VSMC apoptotic process", "up regulation of VSMC apoptotic process", "up regulation of vascular smooth muscle cell apoptotic process", "up regulation of vascular associated smooth muscle cell apoptotic process", "positive regulation of vascular smooth muscle cell apoptotic process", "up-regulation of vascular associated smooth muscle cell apoptotic process", "upregulation of vascular associated smooth muscle cell apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of vascular associated smooth muscle cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]"}
{"concept_id": "C4327741", "aliases": ["down regulation of VSMC apoptotic process", "down regulation of vascular smooth muscle cell apoptotic process", "down-regulation of vascular smooth muscle cell apoptotic process", "downregulation of VSMC apoptotic process", "down-regulation of VSMC apoptotic process", "negative regulation of VSMC apoptotic process", "down-regulation of vascular associated smooth muscle cell apoptotic process", "downregulation of vascular smooth muscle cell apoptotic process", "downregulation of vascular associated smooth muscle cell apoptotic process", "down regulation of vascular associated smooth muscle cell apoptotic process", "negative regulation of vascular smooth muscle cell apoptotic process"], "types": ["T043"], "canonical_name": "negative regulation of vascular associated smooth muscle cell apoptotic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]"}
{"concept_id": "C4327742", "aliases": ["regulation of VSMC apoptotic process", "regulation of vascular smooth muscle cell apoptotic process"], "types": ["T043"], "canonical_name": "regulation of vascular associated smooth muscle cell apoptotic process", "definition": "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]"}
{"concept_id": "C4327743", "aliases": ["up regulation of lymphoid progenitor cell differentiation", "up-regulation of lymphoid progenitor cell differentiation", "upregulation of lymphoid progenitor cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of lymphoid progenitor cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:27010503]"}
{"concept_id": "C4327744", "aliases": ["down-regulation of lymphoid progenitor cell differentiation", "downregulation of lymphoid progenitor cell differentiation", "down regulation of lymphoid progenitor cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of lymphoid progenitor cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:27010503]"}
{"concept_id": "C4327745", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lymphoid progenitor cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:27010503]"}
{"concept_id": "C4327746", "aliases": ["upregulation of myeloid progenitor cell differentiation", "up-regulation of myeloid progenitor cell differentiation", "up regulation of myeloid progenitor cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of myeloid progenitor cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:27010503]"}
{"concept_id": "C4327747", "aliases": ["downregulation of myeloid progenitor cell differentiation", "down regulation of myeloid progenitor cell differentiation", "down-regulation of myeloid progenitor cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of myeloid progenitor cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:27010503]"}
{"concept_id": "C4327748", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myeloid progenitor cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:27010503]"}
{"concept_id": "C4327749", "aliases": ["up regulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "up-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "upregulation of Fc gamma receptor-dependent phagocytosis", "upregulation of Fc-gamma receptor signalling pathway involved in phagocytosis", "upregulation of IgG-mediated phagocytosis", "up-regulation of Fc gamma receptor-dependent phagocytosis", "positive regulation of IgG-mediated phagocytosis", "upregulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "positive regulation of Fc-gamma receptor signalling pathway involved in phagocytosis", "positive regulation of Fc gamma receptor-dependent phagocytosis", "upregulation of Fcgamma receptor-mediated phagocytosis", "up regulation of Fcgamma receptor-mediated phagocytosis", "up regulation of Fc gamma receptor-dependent phagocytosis", "up regulation of Fc-gamma receptor signalling pathway involved in phagocytosis", "up-regulation of Fcgamma receptor-mediated phagocytosis", "up-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis", "up-regulation of IgG-mediated phagocytosis", "up regulation of IgG-mediated phagocytosis", "positive regulation of Fcgamma receptor-mediated phagocytosis"], "types": ["T043"], "canonical_name": "positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis. [GO_REF:0000058, GOC:TermGenie, PMID:18832707]"}
{"concept_id": "C4327750", "aliases": ["down regulation of Fc gamma receptor-dependent phagocytosis", "down regulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "down regulation of Fcgamma receptor-mediated phagocytosis", "negative regulation of Fcgamma receptor-mediated phagocytosis", "down-regulation of Fcgamma receptor-mediated phagocytosis", "negative regulation of Fc gamma receptor-dependent phagocytosis", "downregulation of Fc-gamma receptor signalling pathway involved in phagocytosis", "negative regulation of Fc-gamma receptor signalling pathway involved in phagocytosis", "down-regulation of IgG-mediated phagocytosis", "down-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "down-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis", "negative regulation of IgG-mediated phagocytosis", "downregulation of Fc gamma receptor-dependent phagocytosis", "downregulation of IgG-mediated phagocytosis", "downregulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "down regulation of Fc-gamma receptor signalling pathway involved in phagocytosis", "down regulation of IgG-mediated phagocytosis", "down-regulation of Fc gamma receptor-dependent phagocytosis", "downregulation of Fcgamma receptor-mediated phagocytosis"], "types": ["T043"], "canonical_name": "negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis. [GO_REF:0000058, GOC:TermGenie, PMID:18832707]"}
{"concept_id": "C4327751", "aliases": ["regulation of Fc-gamma receptor signalling pathway involved in phagocytosis", "regulation of IgG-mediated phagocytosis", "regulation of Fcgamma receptor-mediated phagocytosis", "regulation of Fc gamma receptor-dependent phagocytosis"], "types": ["T043"], "canonical_name": "regulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "definition": "Any process that modulates the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis. [GO_REF:0000058, GOC:TermGenie, PMID:18832707]"}
{"concept_id": "C4327752", "aliases": ["up regulation of mitochondrial ATP synthesis coupled electron transport", "up-regulation of mitochondrial ATP synthesis coupled electron transport", "upregulation of mitochondrial ATP synthesis coupled electron transport"], "types": ["T043"], "canonical_name": "positive regulation of mitochondrial ATP synthesis coupled electron transport", "definition": "Any process that activates or increases the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074]"}
{"concept_id": "C4327753", "aliases": ["down-regulation of mitochondrial ATP synthesis coupled electron transport", "down regulation of mitochondrial ATP synthesis coupled electron transport", "downregulation of mitochondrial ATP synthesis coupled electron transport"], "types": ["T043"], "canonical_name": "negative regulation of mitochondrial ATP synthesis coupled electron transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074]"}
{"concept_id": "C4327754", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitochondrial ATP synthesis coupled electron transport", "definition": "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074]"}
{"concept_id": "C4327755", "aliases": ["up regulation of clathrin coat assembly", "up-regulation of clathrin coat assembly", "upregulation of clathrin coat assembly", "up regulation of clathrin cage assembly", "positive regulation of clathrin cage assembly", "upregulation of clathrin cage assembly", "up-regulation of clathrin cage assembly"], "types": ["T043"], "canonical_name": "positive regulation of clathrin coat assembly", "definition": "Any process that activates or increases the frequency, rate or extent of clathrin coat assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15533940]"}
{"concept_id": "C4327756", "aliases": ["down regulation of clathrin cage assembly", "downregulation of clathrin coat assembly", "negative regulation of clathrin cage assembly", "down-regulation of clathrin cage assembly", "downregulation of clathrin cage assembly", "down regulation of clathrin coat assembly", "down-regulation of clathrin coat assembly"], "types": ["T043"], "canonical_name": "negative regulation of clathrin coat assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin coat assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327757", "aliases": ["regulation of clathrin cage assembly"], "types": ["T043"], "canonical_name": "regulation of clathrin coat assembly", "definition": "Any process that modulates the frequency, rate or extent of clathrin coat assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15533940]"}
{"concept_id": "C4327758", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chondroitin 4'-sulfate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22365850]"}
{"concept_id": "C4327759", "aliases": [], "types": ["T040"], "canonical_name": "response to chondroitin 4'-sulfate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22365850]"}
{"concept_id": "C4327760", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chondroitin 6'-sulfate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22365850]"}
{"concept_id": "C4327761", "aliases": [], "types": ["T040"], "canonical_name": "response to chondroitin 6'-sulfate", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22365850]"}
{"concept_id": "C4327762", "aliases": ["upregulation of histone H3-K4 trimethylation", "up regulation of histone H3-K4 trimethylation", "up-regulation of histone H3-K4 trimethylation"], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K4 trimethylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K4 trimethylation. [GO_REF:0000058, GOC:TermGenie, PMID:27541139]"}
{"concept_id": "C4327763", "aliases": ["downregulation of histone H3-K4 trimethylation", "down regulation of histone H3-K4 trimethylation", "down-regulation of histone H3-K4 trimethylation"], "types": ["T043"], "canonical_name": "negative regulation of histone H3-K4 trimethylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 trimethylation. [GO_REF:0000058, GOC:TermGenie, PMID:27541139]"}
{"concept_id": "C4327764", "aliases": [], "types": ["T043"], "canonical_name": "regulation of histone H3-K4 trimethylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K4 trimethylation. [GO_REF:0000058, GOC:TermGenie, PMID:27541139]"}
{"concept_id": "C4327765", "aliases": ["up regulation of retrograde trans-synaptic signaling by neuropeptide", "upregulation of retrograde trans-synaptic signaling by neuropeptide", "up-regulation of retrograde trans-synaptic signaling by neuropeptide"], "types": ["T043"], "canonical_name": "positive regulation of retrograde trans-synaptic signaling by neuropeptide", "definition": "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]"}
{"concept_id": "C4327766", "aliases": ["down regulation of retrograde trans-synaptic signaling by neuropeptide", "downregulation of retrograde trans-synaptic signaling by neuropeptide", "down-regulation of retrograde trans-synaptic signaling by neuropeptide"], "types": ["T043"], "canonical_name": "negative regulation of retrograde trans-synaptic signaling by neuropeptide", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]"}
{"concept_id": "C4327767", "aliases": [], "types": ["T043"], "canonical_name": "regulation of retrograde trans-synaptic signaling by neuropeptide", "definition": "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]"}
{"concept_id": "C4327768", "aliases": [], "types": ["T043"], "canonical_name": "microcystin transport", "definition": "The directed movement of a microcystin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GO_REF:0000065, GOC:TermGenie, PMID:26055554]"}
{"concept_id": "C4327769", "aliases": ["cellular response to aminoacetic acid", "cellular response to glycin", "cellular response to aminoethanoic acid", "cellular response to Gly"], "types": ["T043"], "canonical_name": "cellular response to glycine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18984164]"}
{"concept_id": "C4327770", "aliases": ["response to Gly", "response to aminoethanoic acid", "response to aminoacetic acid", "response to glycin"], "types": ["T040"], "canonical_name": "response to glycine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18984164]"}
{"concept_id": "C4327771", "aliases": [], "types": ["T042"], "canonical_name": "regulation of plant organ formation", "definition": "Any process that modulates the frequency, rate or extent of plant organ formation. [GO_REF:0000058, GOC:tb, GOC:TermGenie]"}
{"concept_id": "C4327772", "aliases": ["intracellular signaling chain involved in up-regulation of cell growth", "intracellular signal transduction involved in up-regulation of cell growth", "intracellular signaling chain involved in upregulation of cell growth", "intracellular signaling chain involved in positive regulation of cell growth", "intracellular signaling chain involved in up regulation of cell growth", "intracellular signal transduction involved in up regulation of cell growth", "intracellular signal transduction involved in upregulation of cell growth"], "types": ["T044"], "canonical_name": "intracellular signal transduction involved in positive regulation of cell growth", "definition": "Any intracellular signal transduction that is involved in positive regulation of cell growth. [GO_REF:0000060, GOC:al, GOC:TermGenie, GOC:vw, PMID:15917811]"}
{"concept_id": "C4327773", "aliases": ["up regulation of Wg signaling pathway involved in midbrain DA neurogenesis", "up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wingless signalling pathway involved in midbrain DA neurogenesis", "upregulation of Wingless signaling pathway involved in mDA neuron differentiation", "up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of Wg signalling pathway involved in midbrain DA neurogenesis", "up regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wg signaling pathway involved in mDA neuron differentiation", "up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production", "upregulation of Wingless signalling pathway involved in midbrain DA neurogenesis", "up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wnt signaling pathway involved in midbrain DA neurogenesis", "up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "up-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation", "positive regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "positive regulation of Wnt signaling pathway involved in mDA neuron differentiation", "up regulation of frizzled signalling pathway involved in midbrain DA neurogenesis", "positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of Wg signalling pathway involved in midbrain DA neurogenesis", "upregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production", "upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wingless signalling pathway involved in midbrain DA neurogenesis", "up regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "positive regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wnt-mediated midbrain DA neuron differentiation", "up regulation of frizzled signaling pathway involved in midbrain DA neurogenesis", "positive regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of Wg signalling pathway involved in midbrain DA neurogenesis", "positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production", "upregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "positive regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "upregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation", "up regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate", "positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production", "positive regulation of Wnt-mediated midbrain DA neuron differentiation", "up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wingless signaling pathway involved in mDA neuron differentiation", "up regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "up regulation of Wg signalling pathway involved in mDA neuron differentiation", "up-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "positive regulation of frizzled signaling pathway involved in mDA neuron differentiation", "up-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis", "upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production", "positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wnt signaling pathway involved in midbrain DA neurogenesis", "up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production", "upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production", "positive regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production", "positive regulation of Wingless signalling pathway involved in mDA neuron differentiation", "up-regulation of Wg signaling pathway involved in midbrain DA neurogenesis", "up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of frizzled signalling pathway involved in midbrain DA neurogenesis", "up-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "up-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation", "up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "up-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation", "up regulation of Wnt-mediated midbrain DA neuron differentiation", "positive regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate", "positive regulation of Wg signaling pathway involved in mDA neuron differentiation", "upregulation of frizzled signaling pathway involved in midbrain DA neurogenesis", "positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of frizzled signalling pathway involved in mDA neuron differentiation", "upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wingless signaling pathway involved in midbrain DA neurogenesis", "upregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production", "positive regulation of frizzled signaling pathway involved in midbrain DA neurogenesis", "up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production", "positive regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis", "up regulation of Wnt signaling pathway involved in mDA neuron differentiation", "up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wg signalling pathway involved in midbrain DA neurogenesis", "upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation", "up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis", "upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production", "positive regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "upregulation of Wg signalling pathway involved in mDA neuron differentiation", "up-regulation of frizzled signaling pathway involved in mDA neuron differentiation", "positive regulation of Wg signalling pathway involved in mDA neuron differentiation", "upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "positive regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "up regulation of Wg signaling pathway involved in mDA neuron differentiation", "up-regulation of frizzled signalling pathway involved in mDA neuron differentiation", "up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of Wg signalling pathway involved in mDA neuron differentiation", "up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "positive regulation of Wingless signaling pathway involved in midbrain DA neurogenesis", "positive regulation of Wg signaling pathway involved in midbrain DA neurogenesis", "up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation", "up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wingless signaling pathway involved in mDA neuron differentiation", "up regulation of frizzled signaling pathway involved in mDA neuron differentiation", "positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "up regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "upregulation of Wingless signalling pathway involved in mDA neuron differentiation", "upregulation of frizzled signalling pathway involved in mDA neuron differentiation", "up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wnt signaling pathway involved in midbrain DA neurogenesis", "upregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "positive regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation", "up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "upregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation", "upregulation of frizzled signaling pathway involved in mDA neuron differentiation", "up-regulation of Wingless signaling pathway involved in mDA neuron differentiation", "positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production", "up regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "positive regulation of frizzled signalling pathway involved in midbrain DA neurogenesis", "up-regulation of Wingless signalling pathway involved in mDA neuron differentiation", "up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of Wnt signaling pathway involved in mDA neuron differentiation", "upregulation of Wingless signaling pathway involved in midbrain DA neurogenesis", "upregulation of Wnt signaling pathway involved in mDA neuron differentiation", "positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "up-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "positive regulation of frizzled signalling pathway involved in mDA neuron differentiation", "upregulation of Wg signaling pathway involved in midbrain DA neurogenesis", "up regulation of Wingless signalling pathway involved in mDA neuron differentiation", "up-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate", "up-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis", "upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production", "positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "up-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis", "up-regulation of Wnt-mediated midbrain DA neuron differentiation", "upregulation of Wg signaling pathway involved in mDA neuron differentiation"], "types": ["T043"], "canonical_name": "positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17244647]"}
{"concept_id": "C4327774", "aliases": ["down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "down regulation of frizzled signaling pathway involved in midbrain DA neurogenesis", "down-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation", "down-regulation of Wg signaling pathway involved in mDA neuron differentiation", "down regulation of Wg signalling pathway involved in midbrain DA neurogenesis", "downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production", "negative regulation of frizzled signaling pathway involved in midbrain DA neurogenesis", "downregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "negative regulation of Wg signalling pathway involved in mDA neuron differentiation", "negative regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "negative regulation of Wingless signaling pathway involved in mDA neuron differentiation", "down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "downregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "down regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "down regulation of Wnt signaling pathway involved in mDA neuron differentiation", "down regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis", "down regulation of Wingless signaling pathway involved in mDA neuron differentiation", "down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production", "down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production", "down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production", "downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production", "negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production", "negative regulation of frizzled signalling pathway involved in mDA neuron differentiation", "down-regulation of Wingless signaling pathway involved in mDA neuron differentiation", "down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation", "downregulation of frizzled signalling pathway involved in midbrain DA neurogenesis", "down-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis", "downregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate", "downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production", "down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "negative regulation of Wnt signaling pathway involved in mDA neuron differentiation", "downregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production", "down regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of frizzled signaling pathway involved in mDA neuron differentiation", "downregulation of Wg signalling pathway involved in mDA neuron differentiation", "down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production", "down regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation", "down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production", "down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production", "down regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wg signalling pathway involved in mDA neuron differentiation", "down-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "downregulation of Wg signaling pathway involved in midbrain DA neurogenesis", "down regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "negative regulation of Wg signaling pathway involved in mDA neuron differentiation", "down regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of Wingless signalling pathway involved in mDA neuron differentiation", "downregulation of frizzled signaling pathway involved in mDA neuron differentiation", "down-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate", "down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production", "down regulation of Wingless signalling pathway involved in midbrain DA neurogenesis", "down regulation of Wnt-mediated midbrain DA neuron differentiation", "down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "down-regulation of Wg signalling pathway involved in midbrain DA neurogenesis", "negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of frizzled signalling pathway involved in mDA neuron differentiation", "down-regulation of frizzled signaling pathway involved in mDA neuron differentiation", "downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production", "negative regulation of Wingless signalling pathway involved in midbrain DA neurogenesis", "negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "negative regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "down-regulation of Wingless signalling pathway involved in mDA neuron differentiation", "negative regulation of Wnt-mediated midbrain DA neuron differentiation", "downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "down regulation of Wingless signalling pathway involved in mDA neuron differentiation", "down regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "down regulation of Wingless signaling pathway involved in midbrain DA neurogenesis", "down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "down-regulation of Wnt-mediated midbrain DA neuron differentiation", "downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of frizzled signalling pathway involved in mDA neuron differentiation", "downregulation of Wnt signaling pathway involved in midbrain DA neurogenesis", "down-regulation of Wg signaling pathway involved in midbrain DA neurogenesis", "negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production", "negative regulation of Wnt signaling pathway involved in midbrain DA neurogenesis", "down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production", "downregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of Wnt signaling pathway involved in mDA neuron differentiation", "down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production", "negative regulation of Wingless signalling pathway involved in mDA neuron differentiation", "downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "downregulation of Wg signaling pathway involved in mDA neuron differentiation", "downregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation", "negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "negative regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis", "downregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "downregulation of Wg signalling pathway involved in midbrain DA neurogenesis", "downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production", "down-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of frizzled signalling pathway involved in mDA neuron differentiation", "down regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "down-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "downregulation of Wnt-mediated midbrain DA neuron differentiation", "down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of Wingless signaling pathway involved in midbrain DA neurogenesis", "negative regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation", "downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production", "down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "down-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production", "negative regulation of frizzled signalling pathway involved in midbrain DA neurogenesis", "downregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "down regulation of Wnt signaling pathway involved in midbrain DA neurogenesis", "downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of Wg signaling pathway involved in midbrain DA neurogenesis", "negative regulation of Wingless signaling pathway involved in midbrain DA neurogenesis", "downregulation of Wingless signalling pathway involved in midbrain DA neurogenesis", "down-regulation of Wnt signaling pathway involved in mDA neuron differentiation", "negative regulation of Wg signaling pathway involved in midbrain DA neurogenesis", "downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "down-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation", "down-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation", "down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "down-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production", "down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "down-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis", "negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production", "down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production", "down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production", "negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of frizzled signaling pathway involved in mDA neuron differentiation", "down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production", "downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "down-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "downregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "downregulation of frizzled signaling pathway involved in midbrain DA neurogenesis", "downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production", "negative regulation of Wg signalling pathway involved in midbrain DA neurogenesis", "negative regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "down regulation of Wg signaling pathway involved in mDA neuron differentiation", "down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production", "down-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis", "downregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production", "negative regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "down regulation of Wg signalling pathway involved in mDA neuron differentiation", "negative regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "down regulation of frizzled signalling pathway involved in midbrain DA neurogenesis", "down-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "negative regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation", "downregulation of Wingless signaling pathway involved in mDA neuron differentiation", "down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production", "negative regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate"], "types": ["T043"], "canonical_name": "negative regulation of Wnt-mediated midbrain dopaminergic neuron differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327775", "aliases": ["regulation of Wingless signalling pathway involved in mDA neuron differentiation", "regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate", "regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production", "regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production", "regulation of frizzled signalling pathway involved in midbrain DA neurogenesis", "regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production", "regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation", "regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate", "regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis", "regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production", "regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production", "regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production", "regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis", "regulation of Wnt-mediated midbrain DA neuron differentiation", "regulation of Wg signaling pathway involved in mDA neuron differentiation", "regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate", "regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation", "regulation of frizzled signalling pathway involved in mDA neuron differentiation", "regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate", "regulation of frizzled signaling pathway involved in midbrain DA neurogenesis", "regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production", "regulation of Wnt signaling pathway involved in midbrain DA neurogenesis", "regulation of Wingless signaling pathway involved in mDA neuron differentiation", "regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation", "regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation", "regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation", "regulation of frizzled signaling pathway involved in mDA neuron differentiation", "regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate", "regulation of Wingless signalling pathway involved in midbrain DA neurogenesis", "regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation", "regulation of Wg signalling pathway involved in mDA neuron differentiation", "regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate", "regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate", "regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate", "regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation", "regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate", "regulation of Wg signaling pathway involved in midbrain DA neurogenesis", "regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation", "regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation", "regulation of Wnt signaling pathway involved in mDA neuron differentiation", "regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production", "regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production", "regulation of Wingless signaling pathway involved in midbrain DA neurogenesis", "regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation", "regulation of Wg signalling pathway involved in midbrain DA neurogenesis"], "types": ["T044"], "canonical_name": "regulation of Wnt-mediated midbrain dopaminergic neuron differentiation", "definition": "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17244647]"}
{"concept_id": "C4327776", "aliases": ["upregulation of plant organ morphogenesis", "up regulation of plant organ morphogenesis", "up-regulation of plant organ morphogenesis"], "types": ["T042"], "canonical_name": "positive regulation of plant organ morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of plant organ morphogenesis. [GO_REF:0000058, GOC:tb, GOC:TermGenie]"}
{"concept_id": "C4327777", "aliases": ["down-regulation of plant organ morphogenesis", "downregulation of plant organ morphogenesis", "down regulation of plant organ morphogenesis"], "types": ["T042"], "canonical_name": "negative regulation of plant organ morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of plant organ morphogenesis. [GO_REF:0000058, GOC:tb, GOC:TermGenie]"}
{"concept_id": "C4327778", "aliases": [], "types": ["T042"], "canonical_name": "regulation of plant organ morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of plant organ morphogenesis. [GO_REF:0000058, GOC:tb, GOC:TermGenie]"}
{"concept_id": "C4327779", "aliases": ["vascular smooth muscle cell differentiation involved in phenotypic switching", "VSMC differentiation involved in phenotypic switching"], "types": ["T043"], "canonical_name": "vascular associated smooth muscle cell differentiation involved in phenotypic switching", "definition": "Any vascular smooth muscle cell differentiation that is involved in phenotypic switching. [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]"}
{"concept_id": "C4327781", "aliases": ["positive regulation of ameboid sperm movement", "upregulation of amoeboid sperm motility", "positive regulation of amoeboid sperm movement", "upregulation of amoeboid sperm movement", "up-regulation of amoeboid sperm movement", "up-regulation of ameboid sperm movement", "upregulation of ameboid sperm movement", "up regulation of amoeboid sperm motility", "up regulation of amoeboid sperm movement", "up regulation of ameboid sperm motility", "up-regulation of amoeboid sperm motility", "up-regulation of ameboid sperm motility", "upregulation of ameboid sperm motility", "up regulation of ameboid sperm movement", "positive regulation of ameboid sperm motility"], "types": ["T043"], "canonical_name": "positive regulation of amoeboid sperm motility", "definition": "Any process that activates or increases the frequency, rate or extent of amoeboid sperm motility. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie]"}
{"concept_id": "C4327782", "aliases": ["down regulation of ameboid sperm motility", "downregulation of ameboid sperm movement", "downregulation of ameboid sperm motility", "negative regulation of amoeboid sperm movement", "down-regulation of amoeboid sperm motility", "downregulation of amoeboid sperm motility", "down regulation of amoeboid sperm movement", "down-regulation of ameboid sperm movement", "down-regulation of ameboid sperm motility", "downregulation of amoeboid sperm movement", "down regulation of amoeboid sperm motility", "down regulation of ameboid sperm movement", "negative regulation of ameboid sperm movement", "down-regulation of amoeboid sperm movement", "negative regulation of ameboid sperm motility"], "types": ["T043"], "canonical_name": "negative regulation of amoeboid sperm motility", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of amoeboid sperm motility. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie]"}
{"concept_id": "C4327783", "aliases": ["regulation of ameboid sperm motility", "regulation of ameboid sperm movement", "regulation of amoeboid sperm movement"], "types": ["T043"], "canonical_name": "regulation of amoeboid sperm motility", "definition": "Any process that modulates the frequency, rate or extent of amoeboid sperm motility. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie]"}
{"concept_id": "C4327784", "aliases": ["upregulation of dense core vesicle exocytosis", "up regulation of dense core vesicle exocytosis", "positive regulation of dense core vesicle exocytosis", "upregulation of dense core granule exocytosis", "up regulation of dense core granule exocytosis", "up-regulation of dense core vesicle exocytosis", "up-regulation of dense core granule exocytosis"], "types": ["T043"], "canonical_name": "positive regulation of dense core granule exocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of dense core granule exocytosis. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511]"}
{"concept_id": "C4327785", "aliases": ["downregulation of dense core granule exocytosis", "down regulation of dense core vesicle exocytosis", "downregulation of dense core vesicle exocytosis", "down-regulation of dense core vesicle exocytosis", "down regulation of dense core granule exocytosis", "down-regulation of dense core granule exocytosis", "negative regulation of dense core vesicle exocytosis"], "types": ["T043"], "canonical_name": "negative regulation of dense core granule exocytosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule exocytosis. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327786", "aliases": ["regulation of dense core vesicle exocytosis"], "types": ["T043"], "canonical_name": "regulation of dense core granule exocytosis", "definition": "Any process that modulates the frequency, rate or extent of dense core granule exocytosis. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511]"}
{"concept_id": "C4327787", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic cohesin loading", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin loading. [GO_REF:0000058, GOC:TermGenie, PMID:26687354]"}
{"concept_id": "C4327788", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic cohesin unloading", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic cohesin unloading. [GO_REF:0000058, GOC:TermGenie, PMID:26687354]"}
{"concept_id": "C4327789", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic cohesin unloading", "definition": "Any process that modulates the frequency, rate or extent of mitotic cohesin unloading. [GO_REF:0000058, GOC:TermGenie, PMID:26687354]"}
{"concept_id": "C4327790", "aliases": ["up regulation of creatine transmembrane transporter activity", "up-regulation of creatine transmembrane transporter activity", "upregulation of creatine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "positive regulation of creatine transmembrane transporter activity", "definition": "Any process that activates or increases the frequency, rate or extent of creatine transmembrane transporter activity. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585]"}
{"concept_id": "C4327791", "aliases": ["downregulation of creatine transmembrane transporter activity", "down regulation of creatine transmembrane transporter activity", "down-regulation of creatine transmembrane transporter activity"], "types": ["T044"], "canonical_name": "negative regulation of creatine transmembrane transporter activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585]"}
{"concept_id": "C4327792", "aliases": [], "types": ["T044"], "canonical_name": "regulation of creatine transmembrane transporter activity", "definition": "Any process that modulates the frequency, rate or extent of creatine transmembrane transporter activity. [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585]"}
{"concept_id": "C4327793", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic cohesin loading", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic cohesin loading. [GO_REF:0000058, GOC:TermGenie, PMID:26687354]"}
{"concept_id": "C4327794", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic cohesin loading", "definition": "Any process that modulates the frequency, rate or extent of mitotic cohesin loading. [GO_REF:0000058, GOC:TermGenie, PMID:26687354]"}
{"concept_id": "C4327795", "aliases": ["positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "up-regulation of activated CD4-positive, alpha-beta T cell apoptotic process", "up regulation of activated CD4-positive, alpha-beta T cell apoptotic process", "positive regulation of activated CD4-positive, alpha-beta T-cell apoptotic process", "upregulation of activated CD4-positive, alpha-beta T cell apoptotic process", "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "up regulation of activated CD4-positive, alpha-beta T-cell apoptotic process", "up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process", "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process", "upregulation of activated CD4-positive, alpha-beta T-cell apoptotic process", "up-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process"], "types": ["T043"], "canonical_name": "positive regulation of activated CD4-positive, alpha-beta T cell apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]"}
{"concept_id": "C4327796", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to flavonoid", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22700048]"}
{"concept_id": "C4327797", "aliases": [], "types": ["T040"], "canonical_name": "response to flavonoid", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22700048]"}
{"concept_id": "C4327798", "aliases": [], "types": ["T044"], "canonical_name": "retromer complex binding", "definition": "Binding to a retromer complex. [GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27385586]"}
{"concept_id": "C4327799", "aliases": [], "types": ["T042"], "canonical_name": "plant organ morphogenesis", "definition": "The developmental process by which a plant organ is generated and organized. [GO_REF:0000083, GOC:tb, GOC:TermGenie]"}
{"concept_id": "C4327800", "aliases": ["regulation of protein localisation to cell division site involved in cell separation following cytokinesis", "regulation of protein localisation to cell division site involved in cell separation after cytokinesis", "regulation of protein localisation to cell division site involved in mitotic cytokinetic cell separation"], "types": ["T043"], "canonical_name": "regulation of protein localization to cell division site involved in cell separation after cytokinesis", "definition": "Any regulation of protein localization to cell division site that is involved in cell separation after cytokinesis. [GO_REF:0000060, GOC:TermGenie, PMID:25411334]"}
{"concept_id": "C4327801", "aliases": ["cellular response to LTB4"], "types": ["T043"], "canonical_name": "cellular response to leukotriene B4", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:14656734]"}
{"concept_id": "C4327802", "aliases": ["response to LTB4"], "types": ["T040"], "canonical_name": "response to leukotriene B4", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:14656734]"}
{"concept_id": "C4327803", "aliases": ["cellular response to beta,beta-carotene"], "types": ["T043"], "canonical_name": "cellular response to beta-carotene", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16771696]"}
{"concept_id": "C4327804", "aliases": ["response to beta,beta-carotene"], "types": ["T040"], "canonical_name": "response to beta-carotene", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:16771696]"}
{"concept_id": "C4327805", "aliases": ["upregulation of protein localisation in presynapse", "upregulation of protein localization to presynapse", "up-regulation of protein localization to presynapse", "up-regulation of protein localisation in presynapse", "upregulation of protein localisation to presynapse", "up-regulation of recruitment of presynaptic proteins", "up regulation of recruitment of presynaptic proteins", "up regulation of protein localisation in presynapse", "positive regulation of protein localisation in presynapse", "up-regulation of protein localization in presynapse", "positive regulation of protein localisation to presynapse", "upregulation of recruitment of presynaptic proteins", "positive regulation of protein localization in presynapse", "up regulation of protein localization to presynapse", "up regulation of protein localization in presynapse", "upregulation of protein localization in presynapse", "up-regulation of protein localisation to presynapse", "up regulation of protein localisation to presynapse", "positive regulation of recruitment of presynaptic proteins"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to presynapse", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]"}
{"concept_id": "C4327806", "aliases": ["downregulation of protein localisation in presynapse", "downregulation of protein localisation to presynapse", "down regulation of protein localization in presynapse", "down-regulation of recruitment of presynaptic proteins", "down-regulation of protein localization to presynapse", "negative regulation of recruitment of presynaptic proteins", "negative regulation of protein localisation to presynapse", "downregulation of protein localization to presynapse", "negative regulation of protein localization in presynapse", "down-regulation of protein localisation to presynapse", "down-regulation of protein localisation in presynapse", "down regulation of protein localisation in presynapse", "down regulation of recruitment of presynaptic proteins", "downregulation of protein localization in presynapse", "negative regulation of protein localisation in presynapse", "downregulation of recruitment of presynaptic proteins", "down regulation of protein localisation to presynapse", "down regulation of protein localization to presynapse", "down-regulation of protein localization in presynapse"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to presynapse", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]"}
{"concept_id": "C4327807", "aliases": ["regulation of protein localization in presynapse", "regulation of recruitment of presynaptic proteins", "regulation of protein localisation to presynapse", "regulation of protein localisation in presynapse"], "types": ["T043"], "canonical_name": "regulation of protein localization to presynapse", "definition": "Any process that modulates the frequency, rate or extent of protein localization to presynapse. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]"}
{"concept_id": "C4327808", "aliases": ["protein localization in presynapse", "protein localisation in presynapse", "recruitment of presynaptic proteins", "protein localisation to presynapse"], "types": ["T043"], "canonical_name": "protein localization to presynapse", "definition": "A process in which a protein is transported to, or maintained in, a location within a presynapse. [GO_REF:0000087, GOC:TermGenie, PMID:24449494]"}
{"concept_id": "C4327809", "aliases": ["upregulation of snRNA transcription from RNA polymerase II promoter", "up-regulation of snRNA transcription from Pol II promoter", "upregulation of snRNA transcription from Pol II promoter", "up regulation of snRNA transcription from Pol II promoter", "positive regulation of snRNA transcription from RNA polymerase II promoter", "up regulation of snRNA transcription from RNA polymerase II promoter", "positive regulation of snRNA transcription from Pol II promoter", "up-regulation of snRNA transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "positive regulation of snRNA transcription by RNA polymerase II", "definition": "Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900]"}
{"concept_id": "C4327810", "aliases": ["negative regulation of snRNA transcription from Pol II promoter", "down-regulation of snRNA transcription from Pol II promoter", "down regulation of snRNA transcription from Pol II promoter", "down-regulation of snRNA transcription from RNA polymerase II promoter", "downregulation of snRNA transcription from Pol II promoter", "down regulation of snRNA transcription from RNA polymerase II promoter", "negative regulation of snRNA transcription from RNA polymerase II promoter", "downregulation of snRNA transcription from RNA polymerase II promoter"], "types": ["T045"], "canonical_name": "negative regulation of snRNA transcription by RNA polymerase II", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900]"}
{"concept_id": "C4327811", "aliases": ["regulation of snRNA transcription from RNA polymerase II promoter", "regulation of snRNA transcription from Pol II promoter"], "types": ["T045"], "canonical_name": "regulation of snRNA transcription by RNA polymerase II", "definition": "Any process that modulates the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900]"}
{"concept_id": "C4327812", "aliases": ["cellular response to D-Gal", "cellular response to D-galacto-hexose"], "types": ["T043"], "canonical_name": "cellular response to D-galactose", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:26261574]"}
{"concept_id": "C4327813", "aliases": ["response to D-galacto-hexose", "response to D-Gal"], "types": ["T040"], "canonical_name": "response to D-galactose", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:26261574]"}
{"concept_id": "C4327814", "aliases": ["down-regulation of cytochrome-c oxidase activity", "negative regulation of cytochrome c oxidase activity", "downregulation of NADH cytochrome c oxidase", "downregulation of cytochrome-c oxidase activity", "down regulation of cytochrome c oxidase activity", "down-regulation of NADH cytochrome c oxidase", "negative regulation of NADH cytochrome c oxidase", "downregulation of cytochrome c oxidase activity", "down regulation of cytochrome-c oxidase activity", "down-regulation of cytochrome c oxidase activity", "down regulation of NADH cytochrome c oxidase"], "types": ["T044"], "canonical_name": "negative regulation of cytochrome-c oxidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cytochrome-c oxidase activity. [GO_REF:0000059, GOC:TermGenie, PMID:26722473]"}
{"concept_id": "C4327815", "aliases": ["cellular response to 2-amino-4-mercaptobutyric acid", "cellular response to Hcy", "cellular response to 2-amino-4-sulfanylbutanoic acid"], "types": ["T043"], "canonical_name": "cellular response to homocysteine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:26722473]"}
{"concept_id": "C4327816", "aliases": ["response to 2-amino-4-sulfanylbutanoic acid", "response to Hcy", "response to 2-amino-4-mercaptobutyric acid"], "types": ["T040"], "canonical_name": "response to homocysteine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:26722473]"}
{"concept_id": "C4327817", "aliases": ["ceramide phosphoethanolamine anabolism", "ceramide phosphoethanolamine synthesis", "ceramide phosphoethanolamine biosynthesis", "ceramide phosphoethanolamine formation"], "types": ["T044"], "canonical_name": "ceramide phosphoethanolamine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ceramide phosphoethanolamine. [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419]"}
{"concept_id": "C4327818", "aliases": ["ceramide phosphoethanolamine degradation", "ceramide phosphoethanolamine breakdown", "ceramide phosphoethanolamine catabolism"], "types": ["T044"], "canonical_name": "ceramide phosphoethanolamine catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of ceramide phosphoethanolamine. [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419]"}
{"concept_id": "C4327819", "aliases": ["ceramide phosphoethanolamine metabolism"], "types": ["T044"], "canonical_name": "ceramide phosphoethanolamine metabolic process", "definition": "The chemical reactions and pathways involving ceramide phosphoethanolamine. [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419]"}
{"concept_id": "C4327820", "aliases": ["up-regulation of endosome membrane budding", "positive regulation of endosome membrane budding", "up-regulation of intralumenal vesicle formation", "up regulation of intralumenal vesicle formation", "up regulation of endosome membrane budding", "upregulation of intralumenal vesicle formation", "upregulation of endosome membrane budding"], "types": ["T043"], "canonical_name": "positive regulation of intralumenal vesicle formation", "definition": "Any process that activates or increases the frequency, rate or extent of intralumenal vesicle formation. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]"}
{"concept_id": "C4327821", "aliases": ["down regulation of endosome membrane budding", "down-regulation of endosome membrane budding", "downregulation of intralumenal vesicle formation", "downregulation of endosome membrane budding", "down regulation of intralumenal vesicle formation", "negative regulation of endosome membrane budding", "down-regulation of intralumenal vesicle formation"], "types": ["T043"], "canonical_name": "negative regulation of intralumenal vesicle formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intralumenal vesicle formation. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]"}
{"concept_id": "C4327822", "aliases": ["regulation of endosome membrane budding"], "types": ["T043"], "canonical_name": "regulation of intralumenal vesicle formation", "definition": "Any process that modulates the frequency, rate or extent of intralumenal vesicle formation. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]"}
{"concept_id": "C4327823", "aliases": ["regulation of endosome vesicle fusion"], "types": ["T043"], "canonical_name": "regulation of endosomal vesicle fusion", "definition": "Any process that modulates the frequency, rate or extent of endosomal vesicle fusion. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]"}
{"concept_id": "C4327824", "aliases": ["up regulation of endosome vesicle fusion", "up-regulation of endosomal vesicle fusion", "up-regulation of endosome vesicle fusion", "upregulation of endosomal vesicle fusion", "up regulation of endosomal vesicle fusion", "upregulation of endosome vesicle fusion", "positive regulation of endosome vesicle fusion"], "types": ["T043"], "canonical_name": "positive regulation of endosomal vesicle fusion", "definition": "Any process that activates or increases the frequency, rate or extent of endosomal vesicle fusion. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]"}
{"concept_id": "C4327825", "aliases": ["down-regulation of endosome vesicle fusion", "down regulation of endosomal vesicle fusion", "down regulation of endosome vesicle fusion", "downregulation of endosomal vesicle fusion", "downregulation of endosome vesicle fusion", "down-regulation of endosomal vesicle fusion", "negative regulation of endosome vesicle fusion"], "types": ["T043"], "canonical_name": "negative regulation of endosomal vesicle fusion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endosomal vesicle fusion. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]"}
{"concept_id": "C4327826", "aliases": ["protein localisation to meiotic spindle"], "types": ["T043"], "canonical_name": "protein localization to meiotic spindle", "definition": "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle. [GO_REF:0000087, GOC:TermGenie, PMID:26696398]"}
{"concept_id": "C4327827", "aliases": ["upregulation of snRNA pseudouridine synthesis", "up regulation of snRNA pseudouridine synthesis", "up-regulation of snRNA pseudouridine synthesis"], "types": ["T045"], "canonical_name": "positive regulation of snRNA pseudouridine synthesis", "definition": "Any process that activates or increases the frequency, rate or extent of snRNA pseudouridine synthesis. [GO_REF:0000058, GOC:TermGenie, PMID:27268497]"}
{"concept_id": "C4327828", "aliases": ["down-regulation of snRNA pseudouridine synthesis", "down regulation of snRNA pseudouridine synthesis", "downregulation of snRNA pseudouridine synthesis"], "types": ["T045"], "canonical_name": "negative regulation of snRNA pseudouridine synthesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of snRNA pseudouridine synthesis. [GO_REF:0000058, GOC:TermGenie, PMID:27268497]"}
{"concept_id": "C4327829", "aliases": [], "types": ["T045"], "canonical_name": "regulation of snRNA pseudouridine synthesis", "definition": "Any process that modulates the frequency, rate or extent of snRNA pseudouridine synthesis. [GO_REF:0000058, GOC:TermGenie, PMID:27268497]"}
{"concept_id": "C4327830", "aliases": ["spine apparatus formation"], "types": ["T043"], "canonical_name": "spine apparatus assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a spine apparatus. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12928494]"}
{"concept_id": "C4327831", "aliases": ["cilium transition fibre formation", "cilial transition fibre assembly", "cilium transition fiber assembly", "cilium transition fibre assembly", "ciliary transition fiber formation", "ciliary transition fibre formation", "cilium transition fiber formation", "cilial transition fibre formation", "cilial transition fiber assembly", "cilial transition fiber formation", "ciliary transition fibre assembly"], "types": ["T044"], "canonical_name": "ciliary transition fiber assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition fiber. [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:24189274]"}
{"concept_id": "C4327832", "aliases": ["ciliary necklace formation", "cilial necklace assembly", "cilium necklace formation", "cilial necklace formation", "cilium necklace assembly"], "types": ["T044"], "canonical_name": "ciliary necklace assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a ciliary necklace. [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:20399632, PMID:6409906]"}
{"concept_id": "C4327833", "aliases": [], "types": ["T043"], "canonical_name": "pericyte cell migration", "definition": "The orderly movement of a pericyte cell from one site to another. [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26268439]"}
{"concept_id": "C4327834", "aliases": ["Y-shaped link formation"], "types": ["T044"], "canonical_name": "Y-shaped link assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a Y-shaped link. Two distinct protein complexes are known to be involved in proper linker assembly: the MKS complex and the NPHP complex. Improper assembly of Y-shaped links may cause malfunctioning of the transition zone as a molecular gate. [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:23728985, PMID:24664739, PMID:26595381, PMID:4554367]"}
{"concept_id": "C4327835", "aliases": ["cilium transition zone assembly", "cilial transition zone formation", "cilial transition zone assembly", "ciliary transition zone formation", "cilium transition zone formation"], "types": ["T043"], "canonical_name": "ciliary transition zone assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032]"}
{"concept_id": "C4327836", "aliases": ["protein localisation to cleavage furrow rim", "protein localisation in cleavage furrow rim", "protein localization in cleavage furrow rim"], "types": ["T043"], "canonical_name": "protein localization to cleavage furrow rim", "definition": "A process in which a protein is transported to, or maintained in, a location within a cleavage furrow rim. [GO_REF:0000087, GOC:TermGenie, PMID:27082518]"}
{"concept_id": "C4327837", "aliases": ["protein localisation in cleavage furrow", "protein localization in cleavage furrow", "protein localisation to cleavage furrow"], "types": ["T043"], "canonical_name": "protein localization to cleavage furrow", "definition": "A process in which a protein is transported to, or maintained in, a location within a cleavage furrow. [GO_REF:0000087, GOC:TermGenie, PMID:27082518]"}
{"concept_id": "C4327838", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cohesin unloading", "definition": "Any process that modulates the frequency, rate or extent of cohesin unloading. [GO_REF:0000058, GOC:TermGenie, PMID:26687354]"}
{"concept_id": "C4327839", "aliases": ["up regulation of protein localization to kinetochore", "upregulation of protein localization to kinetochore", "up-regulation of protein localization to kinetochore", "up-regulation of protein localisation to kinetochore", "upregulation of protein localisation to kinetochore", "positive regulation of protein localisation to kinetochore", "up regulation of protein localisation to kinetochore"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to kinetochore", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore. [GO_REF:0000058, GOC:TermGenie, PMID:22581055]"}
{"concept_id": "C4327840", "aliases": ["down regulation of protein localization to kinetochore", "negative regulation of protein localisation to kinetochore", "down-regulation of protein localization to kinetochore", "down-regulation of protein localisation to kinetochore", "down regulation of protein localisation to kinetochore", "downregulation of protein localisation to kinetochore", "downregulation of protein localization to kinetochore"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to kinetochore", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to kinetochore. [GO_REF:0000058, GOC:TermGenie, PMID:22581055]"}
{"concept_id": "C4327841", "aliases": ["regulation of protein localisation to kinetochore"], "types": ["T043"], "canonical_name": "regulation of protein localization to kinetochore", "definition": "Any process that modulates the frequency, rate or extent of protein localization to kinetochore. [GO_REF:0000058, GOC:TermGenie, PMID:22581055]"}
{"concept_id": "C4327842", "aliases": ["upregulation of cohesin unloading", "up-regulation of cohesin unloading", "up regulation of cohesin unloading"], "types": ["T045"], "canonical_name": "positive regulation of cohesin unloading", "definition": "Any process that activates or increases the frequency, rate or extent of cohesin unloading. [GO_REF:0000058, GOC:TermGenie, PMID:26687354]"}
{"concept_id": "C4327843", "aliases": ["down-regulation of cohesin unloading", "down regulation of cohesin unloading", "downregulation of cohesin unloading"], "types": ["T044"], "canonical_name": "negative regulation of cohesin unloading", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cohesin unloading. [GO_REF:0000058, GOC:TermGenie, PMID:26687354]"}
{"concept_id": "C4327844", "aliases": ["up regulation of aggrephagy", "upregulation of aggrephagy", "up-regulation of aggrephagy"], "types": ["T043"], "canonical_name": "positive regulation of aggrephagy", "definition": "Any process that activates or increases the frequency, rate or extent of aggrephagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]"}
{"concept_id": "C4327845", "aliases": ["downregulation of aggrephagy", "down regulation of aggrephagy", "down-regulation of aggrephagy"], "types": ["T043"], "canonical_name": "negative regulation of aggrephagy", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aggrephagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]"}
{"concept_id": "C4327846", "aliases": [], "types": ["T043"], "canonical_name": "regulation of aggrephagy", "definition": "Any process that modulates the frequency, rate or extent of aggrephagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]"}
{"concept_id": "C4327847", "aliases": ["Sae3-Mei5 complex binding"], "types": ["T044"], "canonical_name": "Swi5-Sfr1 complex binding", "definition": "Binding to a Swi5-Sfr1 complex. [GOC:TermGenie, PMID:16921379]"}
{"concept_id": "C4327848", "aliases": [], "types": ["T042"], "canonical_name": "regulation of gastric motility", "definition": "Any process that modulates the frequency, rate or extent of gastric motility. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:9924029]"}
{"concept_id": "C4327849", "aliases": ["up regulation of epithelium morphogenesis", "upregulation of morphogenesis of an epithelium", "up-regulation of morphogenesis of an epithelium", "positive regulation of epithelium morphogenesis", "upregulation of epithelium morphogenesis", "up-regulation of epithelium morphogenesis", "up regulation of morphogenesis of an epithelium"], "types": ["T042"], "canonical_name": "positive regulation of morphogenesis of an epithelium", "definition": "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]"}
{"concept_id": "C4327850", "aliases": ["down regulation of morphogenesis of an epithelium", "negative regulation of epithelium morphogenesis", "down-regulation of morphogenesis of an epithelium", "downregulation of morphogenesis of an epithelium", "downregulation of epithelium morphogenesis", "down-regulation of epithelium morphogenesis", "down regulation of epithelium morphogenesis"], "types": ["T042"], "canonical_name": "negative regulation of morphogenesis of an epithelium", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]"}
{"concept_id": "C4327851", "aliases": ["regulation of epithelium morphogenesis"], "types": ["T042"], "canonical_name": "regulation of morphogenesis of an epithelium", "definition": "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]"}
{"concept_id": "C4327852", "aliases": ["sphingoid base(1+) transport"], "types": ["T043"], "canonical_name": "sphingoid long-chain base transport", "definition": "The directed movement of a sphingoid long-chain base, sometimes referred to as long-chain base, or sphingoid base, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sphingoid long-chain bases are long-chain aliphatic amines that are the fundamental building blocks of sphingolipids. The main mammalian sphingoid long-chain bases are dihydrosphingosine and sphingosine, while dihydrosphingosine and phytosphingosine are the main sphingoid long-chain bases in yeast. [GO_REF:0000065, GOC:rn, GOC:TermGenie, PMID:27136724]"}
{"concept_id": "C4327853", "aliases": [], "types": ["T042"], "canonical_name": "plant septum development", "definition": "The process whose specific outcome is the progression of a septum over time, from its formation to the mature structure. [GO_REF:0000080, GOC:tb, GOC:TermGenie, PMID:4562349]"}
{"concept_id": "C4327854", "aliases": ["esophagotracheal septum formation"], "types": ["T042"], "canonical_name": "tracheoesophageal septum formation", "definition": "The process that gives rise to the tracheoesophageal septum. This process pertains to the initial formation of a structure from unspecified parts. [GO_REF:0000081, GOC:TermGenie, PMID:9731532]"}
{"concept_id": "C4327855", "aliases": ["upregulation of meiosis I spindle assembly checkpoint", "up-regulation of meiosis I spindle assembly checkpoint", "up regulation of meiosis I spindle assembly checkpoint"], "types": ["T043"], "canonical_name": "positive regulation of meiosis I spindle assembly checkpoint", "definition": "Any process that activates or increases the frequency, rate or extent of the meiosis I spindle assembly checkpoint. [GO_REF:0000058, GOC:TermGenie, PMID:26483559]"}
{"concept_id": "C4327856", "aliases": [], "types": ["T043"], "canonical_name": "regulation of meiosis I spindle assembly checkpoint", "definition": "Any process that modulates the frequency, rate or extent of the meiosis I spindle assembly checkpoint. [GO_REF:0000058, GOC:TermGenie, PMID:26483559]"}
{"concept_id": "C4327857", "aliases": ["telomere-telomerase complex formation"], "types": ["T044"], "canonical_name": "telomere-telomerase complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a telomere-telomerase complex. [GO_REF:0000079, GOC:TermGenie, PMID:26305931]"}
{"concept_id": "C4327858", "aliases": ["telomerase holoenzyme complex formation"], "types": ["T044"], "canonical_name": "telomerase holoenzyme complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a telomerase holoenzyme complex. [GO_REF:0000079, GOC:TermGenie, PMID:26305931]"}
{"concept_id": "C4327859", "aliases": ["upregulation of mesenchymal stem cell migration", "up-regulation of mesenchymal stem cell migration", "up regulation of mesenchymal stem cell migration"], "types": ["T043"], "canonical_name": "positive regulation of mesenchymal stem cell migration", "definition": "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration. [GO_REF:0000058, GOC:TermGenie, PMID:26846297]"}
{"concept_id": "C4327860", "aliases": ["down regulation of mesenchymal stem cell migration", "down-regulation of mesenchymal stem cell migration", "downregulation of mesenchymal stem cell migration"], "types": ["T043"], "canonical_name": "negative regulation of mesenchymal stem cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration. [GO_REF:0000058, GOC:TermGenie, PMID:26846297]"}
{"concept_id": "C4327861", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mesenchymal stem cell migration", "definition": "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration. [GO_REF:0000058, GOC:TermGenie, PMID:26846297]"}
{"concept_id": "C4327862", "aliases": [], "types": ["T043"], "canonical_name": "mesenchymal stem cell migration", "definition": "The orderly movement of a mesenchymal stem cell from one site to another. [GO_REF:0000091, GOC:TermGenie, PMID:24924806, PMID:25181476]"}
{"concept_id": "C4327863", "aliases": ["meiosis I spindle assembly checkpoint"], "types": ["T043"], "canonical_name": "meiosis I spindle assembly checkpoint signaling", "definition": "Any spindle assembly checkpoint that is involved in meiosis I. [GO_REF:0000060, GOC:TermGenie, PMID:26483559]"}
{"concept_id": "C4327864", "aliases": ["ventral endocardial cushion morphogenesis"], "types": ["T042"], "canonical_name": "inferior endocardial cushion morphogenesis", "definition": "The developmental process by which an inferior endocardial cushion is generated and organized. [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17050629]"}
{"concept_id": "C4327865", "aliases": ["dorsal endocardial cushion morphogenesis"], "types": ["T042"], "canonical_name": "superior endocardial cushion morphogenesis", "definition": "The developmental process by which a superior endocardial cushion is generated and organized. [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17050629]"}
{"concept_id": "C4327866", "aliases": [], "types": ["T043"], "canonical_name": "cell proliferation involved in endocardial cushion morphogenesis", "definition": "Any cell proliferation that is involved in endocardial cushion morphogenesis. [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20652948]"}
{"concept_id": "C4327867", "aliases": ["semilunar valves development", "semilunar valve development"], "types": ["T042"], "canonical_name": "semi-lunar valve development", "definition": "The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure. [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19409885]"}
{"concept_id": "C4327868", "aliases": ["transforming growth factor beta receptor signalling pathway involved in heart development", "TGF-beta receptor signalling pathway involved in heart development", "TGFbeta receptor signaling pathway involved in heart development", "TGF-beta receptor signaling pathway involved in heart development", "TGFbeta receptor signalling pathway involved in heart development"], "types": ["T044"], "canonical_name": "transforming growth factor beta receptor signaling pathway involved in heart development", "definition": "Any transforming growth factor beta receptor signaling pathway that is involved in heart development. [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16140292]"}
{"concept_id": "C4327869", "aliases": ["up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", "up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", "upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis"], "types": ["T043"], "canonical_name": "positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]"}
{"concept_id": "C4327870", "aliases": ["down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", "downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", "down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis"], "types": ["T043"], "canonical_name": "negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]"}
{"concept_id": "C4327871", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]"}
{"concept_id": "C4327872", "aliases": ["positive regulation of cohesin localization to chromatin", "positive regulation of cohesin association with chromatin"], "types": ["T044"], "canonical_name": "positive regulation of cohesin loading", "definition": "Any process that activates or increases the frequency, rate or extent of cohesin loading. [GO_REF:0000058, GOC:TermGenie, PMID:26687354]"}
{"concept_id": "C4327873", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to miconazole", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:26108447]"}
{"concept_id": "C4327874", "aliases": [], "types": ["T040"], "canonical_name": "response to miconazole", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:26108447]"}
{"concept_id": "C4327875", "aliases": ["regulation of cardiac myofibril development", "regulation of cardiac myofibril morphogenesis"], "types": ["T043"], "canonical_name": "regulation of cardiac myofibril assembly", "definition": "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]"}
{"concept_id": "C4327876", "aliases": ["upregulation of macropinocytosis", "up regulation of macropinocytosis", "up-regulation of macropinocytosis"], "types": ["T043"], "canonical_name": "positive regulation of macropinocytosis", "definition": "Any process that activates or increases the frequency, rate or extent of macropinocytosis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641]"}
{"concept_id": "C4327877", "aliases": ["downregulation of macropinocytosis", "down regulation of macropinocytosis", "down-regulation of macropinocytosis"], "types": ["T043"], "canonical_name": "negative regulation of macropinocytosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of macropinocytosis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641]"}
{"concept_id": "C4327878", "aliases": [], "types": ["T043"], "canonical_name": "regulation of macropinocytosis", "definition": "Any process that modulates the frequency, rate or extent of macropinocytosis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641]"}
{"concept_id": "C4327879", "aliases": ["up regulation of intestinal epithelial cell development", "upregulation of intestinal epithelial cell development", "up-regulation of intestinal epithelial cell development"], "types": ["T043"], "canonical_name": "positive regulation of intestinal epithelial cell development", "definition": "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268]"}
{"concept_id": "C4327880", "aliases": ["down-regulation of intestinal epithelial cell development", "down regulation of intestinal epithelial cell development", "downregulation of intestinal epithelial cell development"], "types": ["T043"], "canonical_name": "negative regulation of intestinal epithelial cell development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268]"}
{"concept_id": "C4327881", "aliases": [], "types": ["T043"], "canonical_name": "regulation of intestinal epithelial cell development", "definition": "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268]"}
{"concept_id": "C4327882", "aliases": ["upregulation of neural crest cell fate specification", "up-regulation of neural crest cell fate specification", "up regulation of neural crest cell fate specification"], "types": ["T043"], "canonical_name": "positive regulation of neural crest cell fate specification", "definition": "Any process that activates or increases the frequency, rate or extent of neural crest cell fate specification. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]"}
{"concept_id": "C4327883", "aliases": ["down regulation of neural crest cell fate specification", "down-regulation of neural crest cell fate specification", "downregulation of neural crest cell fate specification"], "types": ["T043"], "canonical_name": "negative regulation of neural crest cell fate specification", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell fate specification. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]"}
{"concept_id": "C4327884", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neural crest cell fate specification", "definition": "Any process that modulates the frequency, rate or extent of neural crest cell fate specification. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]"}
{"concept_id": "C4327885", "aliases": ["up-regulation of neural crest cell differentiation", "up regulation of neural crest cell differentiation", "upregulation of neural crest cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of neural crest cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]"}
{"concept_id": "C4327886", "aliases": ["down-regulation of neural crest cell differentiation", "downregulation of neural crest cell differentiation", "down regulation of neural crest cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of neural crest cell differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]"}
{"concept_id": "C4327887", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neural crest cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of neural crest cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]"}
{"concept_id": "C4327888", "aliases": ["upregulation of CAMKK-AMPK signaling cascade", "up-regulation of CAMKK-AMPK signaling cascade", "up regulation of CAMKK-AMPK signaling cascade"], "types": ["T044"], "canonical_name": "positive regulation of CAMKK-AMPK signaling cascade", "definition": "Any process that activates or increases the frequency, rate or extent of CAMKK-AMPK signaling cascade. [GO_REF:0000058, GOC:TermGenie, PMID:22128786]"}
{"concept_id": "C4327889", "aliases": ["downregulation of CAMKK-AMPK signaling cascade", "down-regulation of CAMKK-AMPK signaling cascade", "down regulation of CAMKK-AMPK signaling cascade"], "types": ["T044"], "canonical_name": "negative regulation of CAMKK-AMPK signaling cascade", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CAMKK-AMPK signaling cascade. [GO_REF:0000058, GOC:TermGenie, PMID:22128786]"}
{"concept_id": "C4327890", "aliases": [], "types": ["T044"], "canonical_name": "regulation of CAMKK-AMPK signaling cascade", "definition": "Any process that modulates the frequency, rate or extent of CAMKK-AMPK signaling cascade. [GO_REF:0000058, GOC:TermGenie, PMID:22128786]"}
{"concept_id": "C4327891", "aliases": ["positive regulation of mitotic entry involved in cellular response to nitrogen starvation"], "types": ["T043"], "canonical_name": "positive regulation of G2/M transition of mitotic cell cycle involved in cellular response to nitrogen starvation", "definition": "Any positive regulation of G2/M transition of mitotic cell cycle that is involved in cellular response to nitrogen starvation. [GO_REF:0000060, GOC:TermGenie, PMID:26776736]"}
{"concept_id": "C4327892", "aliases": ["anulus fibrosus of heart morphogenesis"], "types": ["T042"], "canonical_name": "fibrous ring of heart morphogenesis", "definition": "The developmental process by which a fibrous ring of heart is generated and organized. [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16037571]"}
{"concept_id": "C4327893", "aliases": ["up regulation of retrograde transport, endosome to Golgi", "up-regulation of retrograde transport, endosome to Golgi", "upregulation of retrograde (endosome to Golgi) transport", "up regulation of retrograde (endosome to Golgi) transport", "upregulation of retrograde transport, endosome to Golgi", "positive regulation of retrograde (endosome to Golgi) transport", "up-regulation of retrograde (endosome to Golgi) transport"], "types": ["T043"], "canonical_name": "positive regulation of retrograde transport, endosome to Golgi", "definition": "Any process that activates or increases the frequency, rate or extent of retrograde transport, endosome to Golgi. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327894", "aliases": ["negative regulation of retrograde (endosome to Golgi) transport", "downregulation of retrograde transport, endosome to Golgi", "down-regulation of retrograde transport, endosome to Golgi", "down-regulation of retrograde (endosome to Golgi) transport", "down regulation of retrograde (endosome to Golgi) transport", "down regulation of retrograde transport, endosome to Golgi", "downregulation of retrograde (endosome to Golgi) transport"], "types": ["T043"], "canonical_name": "negative regulation of retrograde transport, endosome to Golgi", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde transport, endosome to Golgi. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327895", "aliases": ["regulation of retrograde (endosome to Golgi) transport"], "types": ["T043"], "canonical_name": "regulation of retrograde transport, endosome to Golgi", "definition": "Any process that modulates the frequency, rate or extent of retrograde transport, endosome to Golgi. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23395371]"}
{"concept_id": "C4327896", "aliases": ["up-regulation of epithelial tube formation", "up regulation of epithelial tube formation", "upregulation of epithelial tube formation"], "types": ["T042"], "canonical_name": "positive regulation of epithelial tube formation", "definition": "Any process that activates or increases the frequency, rate or extent of epithelial tube formation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]"}
{"concept_id": "C4327897", "aliases": ["down regulation of epithelial tube formation", "downregulation of epithelial tube formation", "down-regulation of epithelial tube formation"], "types": ["T042"], "canonical_name": "negative regulation of epithelial tube formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]"}
{"concept_id": "C4327898", "aliases": [], "types": ["T039"], "canonical_name": "regulation of epithelial tube formation", "definition": "Any process that modulates the frequency, rate or extent of epithelial tube formation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]"}
{"concept_id": "C4327899", "aliases": [], "types": ["T043"], "canonical_name": "Rohon-Beard neuron differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a Rohon-Beard neuron. [GO_REF:0000086, GOC:TermGenie, ZFIN:ZDB-PUB-120807-45]"}
{"concept_id": "C4327900", "aliases": ["regulation of postsynaptic actin cytoskeleton remodelling"], "types": ["T043"], "canonical_name": "regulation of modification of postsynaptic actin cytoskeleton", "definition": "Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton. [GO_REF:0000058, GOC:TermGenie, PMID:21068295]"}
{"concept_id": "C4327901", "aliases": ["positive regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism", "up-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism", "upregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism", "up-regulation of H+-transporting ATP synthase activity", "upregulation of H+-transporting ATP synthase activity", "up-regulation of hydrogen ion transporting two-sector ATPase activity", "up regulation of proton-transporting ATP synthase activity, rotational mechanism", "upregulation of hydrogen ion translocating F-type ATPase activity", "upregulation of hydrogen ion transporting two-sector ATPase activity", "upregulation of proton-transporting ATP synthase activity, rotational mechanism", "positive regulation of hydrogen ion translocating F-type ATPase activity", "positive regulation of H+-transporting ATP synthase activity", "up-regulation of proton-transporting ATP synthase activity, rotational mechanism", "up regulation of hydrogen ion transporting two-sector ATPase activity", "positive regulation of hydrogen ion transporting two-sector ATPase activity", "up regulation of hydrogen ion translocating F-type ATPase activity", "up regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism", "up-regulation of hydrogen ion translocating F-type ATPase activity", "up regulation of H+-transporting ATP synthase activity"], "types": ["T044"], "canonical_name": "positive regulation of proton-transporting ATP synthase activity, rotational mechanism", "definition": "Any process that activates or increases the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936]"}
{"concept_id": "C4327902", "aliases": ["downregulation of H+-transporting ATP synthase activity", "down regulation of hydrogen ion translocating F-type ATPase activity", "down regulation of proton-transporting ATP synthase activity, rotational mechanism", "down-regulation of H+-transporting ATP synthase activity", "negative regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism", "downregulation of proton-transporting ATP synthase activity, rotational mechanism", "negative regulation of hydrogen ion translocating F-type ATPase activity", "down regulation of hydrogen ion transporting two-sector ATPase activity", "downregulation of hydrogen ion transporting two-sector ATPase activity", "downregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism", "down-regulation of hydrogen ion transporting two-sector ATPase activity", "negative regulation of H+-transporting ATP synthase activity", "down-regulation of hydrogen ion translocating F-type ATPase activity", "down-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism", "downregulation of hydrogen ion translocating F-type ATPase activity", "down regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism", "negative regulation of hydrogen ion transporting two-sector ATPase activity", "down-regulation of proton-transporting ATP synthase activity, rotational mechanism", "down regulation of H+-transporting ATP synthase activity"], "types": ["T044"], "canonical_name": "negative regulation of proton-transporting ATP synthase activity, rotational mechanism", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936]"}
{"concept_id": "C4327903", "aliases": ["regulation of hydrogen ion transporting two-sector ATPase activity", "regulation of hydrogen ion translocating F-type ATPase activity", "regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism", "regulation of H+-transporting ATP synthase activity"], "types": ["T044"], "canonical_name": "regulation of proton-transporting ATP synthase activity, rotational mechanism", "definition": "Any process that modulates the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism. [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936]"}
{"concept_id": "C4327904", "aliases": [], "types": ["T043"], "canonical_name": "Meynert cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a Meynert cell. [GO_REF:0000086, GOC:TermGenie, PMID:4142639]"}
{"concept_id": "C4327905", "aliases": ["up-regulation of chromatin organisation", "positive regulation of establishment or maintenance of chromatin architecture", "up regulation of chromatin organization", "up regulation of chromatin organisation", "positive regulation of chromatin organisation", "up regulation of establishment or maintenance of chromatin architecture", "upregulation of chromatin assembly or disassembly", "up-regulation of establishment or maintenance of chromatin architecture", "upregulation of establishment or maintenance of chromatin architecture", "up-regulation of chromatin organization", "upregulation of chromatin organization", "upregulation of chromatin organisation"], "types": ["T043"], "canonical_name": "positive regulation of chromatin organization", "definition": "Any process that activates or increases the frequency, rate or extent of chromatin organization. [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321]"}
{"concept_id": "C4327906", "aliases": ["downregulation of chromatin organisation", "negative regulation of establishment or maintenance of chromatin architecture", "downregulation of establishment or maintenance of chromatin architecture", "down-regulation of establishment or maintenance of chromatin architecture", "down regulation of chromatin organisation", "down-regulation of chromatin organization", "negative regulation of chromatin assembly/disassembly", "down regulation of chromatin organization", "down-regulation of chromatin organisation", "downregulation of chromatin organization", "down regulation of establishment or maintenance of chromatin architecture", "negative regulation of chromatin organisation"], "types": ["T043"], "canonical_name": "negative regulation of chromatin organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321]"}
{"concept_id": "C4327907", "aliases": ["RNA phosphodiester bond hydrolysis, endonucleolytic involved in tRNA maturation"], "types": ["T045"], "canonical_name": "endonucleolytic cleavage involved in tRNA processing", "definition": "Any endonucleolytic RNA phosphodiester bond hydrolysis that is involved in tRNA processing. [GO_REF:0000060, GOC:TermGenie, PMID:25401760]"}
{"concept_id": "C4327908", "aliases": ["blasticidin S anabolism", "blasticidin S synthesis", "blasticidin S biosynthesis", "blasticidin S formation"], "types": ["T044"], "canonical_name": "blasticidin S biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of blasticidin S. [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S]"}
{"concept_id": "C4327909", "aliases": ["blasticidin S breakdown", "blasticidin S degradation", "blasticidin S catabolism"], "types": ["T044"], "canonical_name": "blasticidin S catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of blasticidin S. [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S]"}
{"concept_id": "C4327910", "aliases": ["blasticidin S metabolism"], "types": ["T044"], "canonical_name": "blasticidin S metabolic process", "definition": "The chemical reactions and pathways involving blasticidin S. [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S]"}
{"concept_id": "C4327911", "aliases": ["up regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "up-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "upregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"], "types": ["T043"], "canonical_name": "positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "definition": "Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. [GO_REF:0000058, GOC:TermGenie, PMID:26653857]"}
{"concept_id": "C4327912", "aliases": ["down-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "downregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "down regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"], "types": ["T043"], "canonical_name": "negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. [GO_REF:0000058, GOC:TermGenie, PMID:26653857]"}
{"concept_id": "C4327913", "aliases": [], "types": ["T043"], "canonical_name": "regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "definition": "Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. [GO_REF:0000058, GOC:TermGenie, PMID:26653857]"}
{"concept_id": "C4327914", "aliases": ["up-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "upregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "up regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "positive regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress", "up regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress", "upregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress", "up-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress"], "types": ["T043"], "canonical_name": "positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327915", "aliases": ["downregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "down regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress", "down regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "negative regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress", "downregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress", "down-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress", "down-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway"], "types": ["T043"], "canonical_name": "negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14752510]"}
{"concept_id": "C4327916", "aliases": ["regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress"], "types": ["T043"], "canonical_name": "regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14752510]"}
{"concept_id": "C4327917", "aliases": ["up regulation of RNA binding transcription factor activity", "up-regulation of RNA binding transcription factor activity", "upregulation of RNA binding transcription factor activity"], "types": ["T044"], "canonical_name": "positive regulation of RNA binding transcription factor activity", "definition": "Any process that activates or increases the frequency, rate or extent of RNA binding transcription factor activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364]"}
{"concept_id": "C4327918", "aliases": ["down-regulation of RNA binding transcription factor activity", "downregulation of RNA binding transcription factor activity", "down regulation of RNA binding transcription factor activity"], "types": ["T044"], "canonical_name": "negative regulation of RNA binding transcription factor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding transcription factor activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327919", "aliases": [], "types": ["T044"], "canonical_name": "regulation of RNA binding transcription factor activity", "definition": "Any process that modulates the frequency, rate or extent of RNA binding transcription factor activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364]"}
{"concept_id": "C4327920", "aliases": ["EGFR signaling pathway involved in heart process", "receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process", "EGF receptor signalling pathway involved in heart process", "EGF receptor signaling pathway involved in heart process", "epidermal growth factor receptor signalling pathway involved in heart process", "ERBB1 signaling pathway involved in heart process"], "types": ["T044"], "canonical_name": "epidermal growth factor receptor signaling pathway involved in heart process", "definition": "Any epidermal growth factor receptor signaling pathway that is involved in heart process. [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]"}
{"concept_id": "C4327921", "aliases": ["up-regulation of aspartic-type peptidase activity", "up regulation of aspartic-type peptidase activity", "upregulation of aspartic-type peptidase activity"], "types": ["T044"], "canonical_name": "positive regulation of aspartic-type peptidase activity", "definition": "Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity. [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575]"}
{"concept_id": "C4327922", "aliases": ["down regulation of aspartic-type peptidase activity", "downregulation of aspartic-type peptidase activity", "down-regulation of aspartic-type peptidase activity"], "types": ["T044"], "canonical_name": "negative regulation of aspartic-type peptidase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type peptidase activity. [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575]"}
{"concept_id": "C4327923", "aliases": [], "types": ["T044"], "canonical_name": "regulation of aspartic-type peptidase activity", "definition": "Any process that modulates the frequency, rate or extent of aspartic-type peptidase activity. [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575]"}
{"concept_id": "C4327924", "aliases": ["regulation of synapse remodelling"], "types": ["T043"], "canonical_name": "regulation of modification of synaptic structure", "definition": "Any process that modulates the frequency, rate or extent of modification of synaptic structure. [GO_REF:0000058, GOC:TermGenie, PMID:25164660]"}
{"concept_id": "C4327925", "aliases": ["cellular response to Liothyroninum", "cellular response to Liothyronine", "cellular response to Liothyronin"], "types": ["T043"], "canonical_name": "cellular response to 3,3',5-triiodo-L-thyronine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21382270]"}
{"concept_id": "C4327926", "aliases": ["response to Liothyroninum", "response to Liothyronin", "response to Liothyronine"], "types": ["T040"], "canonical_name": "response to 3,3',5-triiodo-L-thyronine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21382270]"}
{"concept_id": "C4327927", "aliases": ["positive regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "upregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "up regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "up regulation of canonical Wnt signaling pathway involved in osteoblast differentiation", "up regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "up-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "upregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation", "up-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "positive regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation", "up-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation", "positive regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "up regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation", "upregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "upregulation of canonical Wnt signaling pathway involved in osteoblast differentiation", "up-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation"], "types": ["T043"], "canonical_name": "positive regulation of canonical Wnt signaling pathway involved in osteoblast differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382]"}
{"concept_id": "C4327928", "aliases": ["downregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "down-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation", "down regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation", "negative regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "down regulation of canonical Wnt signaling pathway involved in osteoblast differentiation", "downregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "downregulation of canonical Wnt signaling pathway involved in osteoblast differentiation", "down regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "downregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation", "down-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "negative regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "negative regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation", "down regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "down-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "down-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation"], "types": ["T043"], "canonical_name": "negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382]"}
{"concept_id": "C4327929", "aliases": ["regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation", "regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation", "regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation"], "types": ["T043"], "canonical_name": "regulation of canonical Wnt signaling pathway involved in osteoblast differentiation", "definition": "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382]"}
{"concept_id": "C4327930", "aliases": ["cellular response to cyclophilin"], "types": ["T043"], "canonical_name": "cellular response to cyclosporin A", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24914722]"}
{"concept_id": "C4327931", "aliases": ["response to cyclophilin"], "types": ["T040"], "canonical_name": "response to cyclosporin A", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24914722]"}
{"concept_id": "C4327932", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to quercetin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24914722]"}
{"concept_id": "C4327933", "aliases": [], "types": ["T040"], "canonical_name": "response to quercetin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24914722]"}
{"concept_id": "C4327934", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to codeine", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24914722]"}
{"concept_id": "C4327935", "aliases": [], "types": ["T040"], "canonical_name": "response to codeine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24914722]"}
{"concept_id": "C4327936", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to L-glutamate", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25962137]"}
{"concept_id": "C4327937", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to borneol", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:26593909]"}
{"concept_id": "C4327938", "aliases": [], "types": ["T040"], "canonical_name": "response to borneol", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:26593909]"}
{"concept_id": "C4327939", "aliases": ["upregulation of adhesion of symbiont to host epithelial cell", "up regulation of adhesion of symbiont to host epithelial cell", "up-regulation of adhesion of symbiont to host epithelial cell"], "types": ["T043"], "canonical_name": "positive regulation of adhesion of symbiont to host epithelial cell", "definition": "Any process that activates or increases the frequency, rate or extent of adhesion of symbiont to host epithelial cell. [GO_REF:0000058, GOC:TermGenie, PMID:15659068]"}
{"concept_id": "C4327940", "aliases": ["downregulation of adhesion of symbiont to host epithelial cell", "down regulation of adhesion of symbiont to host epithelial cell", "down-regulation of adhesion of symbiont to host epithelial cell"], "types": ["T043"], "canonical_name": "negative regulation of adhesion of symbiont to host epithelial cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of adhesion of symbiont to host epithelial cell. [GO_REF:0000058, GOC:TermGenie, PMID:15659068]"}
{"concept_id": "C4327941", "aliases": [], "types": ["T043"], "canonical_name": "regulation of adhesion of symbiont to host epithelial cell", "definition": "Any process that modulates the frequency, rate or extent of adhesion of symbiont to host epithelial cell. [GO_REF:0000058, GOC:TermGenie, PMID:15659068]"}
{"concept_id": "C4327942", "aliases": ["coated pit formation", "clathrin-coated pit formation", "coated pit assembly"], "types": ["T043"], "canonical_name": "clathrin-coated pit assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a clathrin-coated pit. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]"}
{"concept_id": "C4327943", "aliases": ["heart epicardium morphogenesis", "visceral serous pericardium of heart morphogenesis", "visceral serous pericardium proper morphogenesis"], "types": ["T042"], "canonical_name": "epicardium morphogenesis", "definition": "The developmental process by which an epicardium is generated and organized. [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]"}
{"concept_id": "C4327944", "aliases": ["AVC morphogenesis", "atrial canal morphogenesis", "atrio-ventricular canal morphogenesis", "AV canal morphogenesis"], "types": ["T042"], "canonical_name": "atrioventricular canal morphogenesis", "definition": "The developmental process by which an atrioventricular canal is generated and organized. [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19703439]"}
{"concept_id": "C4327945", "aliases": ["positive regulation of platelet extrusion", "upregulation of platelet extrusion", "up regulation of platelet extrusion", "upregulation of platelet formation", "up-regulation of platelet extrusion", "up regulation of platelet formation", "up-regulation of platelet formation"], "types": ["T043"], "canonical_name": "positive regulation of platelet formation", "definition": "Any process that activates or increases the frequency, rate or extent of platelet formation. [GO_REF:0000058, GOC:TermGenie, PMID:10606160]"}
{"concept_id": "C4327946", "aliases": ["down-regulation of platelet formation", "down regulation of platelet formation", "negative regulation of platelet extrusion", "down-regulation of platelet extrusion", "down regulation of platelet extrusion", "downregulation of platelet formation", "downregulation of platelet extrusion"], "types": ["T043"], "canonical_name": "negative regulation of platelet formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of platelet formation. [GO_REF:0000058, GOC:TermGenie, PMID:10606160]"}
{"concept_id": "C4327947", "aliases": ["regulation of platelet extrusion"], "types": ["T039"], "canonical_name": "regulation of platelet formation", "definition": "Any process that modulates the frequency, rate or extent of platelet formation. [GO_REF:0000058, GOC:TermGenie, PMID:10606160]"}
{"concept_id": "C4327948", "aliases": ["cellular response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione"], "types": ["T043"], "canonical_name": "cellular response to astaxanthin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22309505]"}
{"concept_id": "C4327949", "aliases": ["response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione"], "types": ["T040"], "canonical_name": "response to astaxanthin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22309505]"}
{"concept_id": "C4327950", "aliases": ["up-regulation of RNA binding", "up regulation of RNA binding", "upregulation of RNA binding"], "types": ["T044"], "canonical_name": "positive regulation of RNA binding", "definition": "Any process that activates or increases the frequency, rate or extent of RNA binding. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364]"}
{"concept_id": "C4327951", "aliases": ["downregulation of RNA binding", "down-regulation of RNA binding", "down regulation of RNA binding"], "types": ["T044"], "canonical_name": "negative regulation of RNA binding", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327952", "aliases": [], "types": ["T044"], "canonical_name": "regulation of RNA binding", "definition": "Any process that modulates the frequency, rate or extent of RNA binding. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327953", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic chromosome condensation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation. [GO_REF:0000058, GOC:TermGenie, PMID:23219725]"}
{"concept_id": "C4327954", "aliases": ["up-regulation of fibroblast chemotaxis", "upregulation of fibroblast chemotaxis", "up regulation of fibroblast chemotaxis"], "types": ["T043"], "canonical_name": "positive regulation of fibroblast chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of fibroblast chemotaxis. [GO_REF:0000058, GOC:TermGenie, PMID:8760137]"}
{"concept_id": "C4327955", "aliases": ["downregulation of fibroblast chemotaxis", "down regulation of fibroblast chemotaxis", "down-regulation of fibroblast chemotaxis"], "types": ["T043"], "canonical_name": "negative regulation of fibroblast chemotaxis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast chemotaxis. [GO_REF:0000058, GOC:TermGenie, PMID:8760137]"}
{"concept_id": "C4327956", "aliases": [], "types": ["T043"], "canonical_name": "regulation of fibroblast chemotaxis", "definition": "Any process that modulates the frequency, rate or extent of fibroblast chemotaxis. [GO_REF:0000058, GOC:TermGenie, PMID:8760137]"}
{"concept_id": "C4327957", "aliases": ["up-regulation of cardiocyte differentiation", "up-regulation of cardiac cell differentiation", "up regulation of cardiac cell differentiation", "up-regulation of heart cell differentiation", "up regulation of cardiocyte differentiation", "positive regulation of heart cell differentiation", "upregulation of cardiocyte differentiation", "upregulation of cardiac cell differentiation", "upregulation of heart cell differentiation", "up regulation of heart cell differentiation", "positive regulation of cardiac cell differentiation"], "types": ["T043"], "canonical_name": "positive regulation of cardiocyte differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]"}
{"concept_id": "C4327958", "aliases": ["down-regulation of heart cell differentiation", "downregulation of cardiocyte differentiation", "down regulation of cardiac cell differentiation", "negative regulation of cardiac cell differentiation", "down regulation of cardiocyte differentiation", "down regulation of heart cell differentiation", "negative regulation of heart cell differentiation", "downregulation of cardiac cell differentiation", "down-regulation of cardiocyte differentiation", "downregulation of heart cell differentiation", "down-regulation of cardiac cell differentiation"], "types": ["T043"], "canonical_name": "negative regulation of cardiocyte differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]"}
{"concept_id": "C4327959", "aliases": ["regulation of cardiac cell differentiation", "regulation of heart cell differentiation"], "types": ["T043"], "canonical_name": "regulation of cardiocyte differentiation", "definition": "Any process that modulates the frequency, rate or extent of cardiocyte differentiation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]"}
{"concept_id": "C4327960", "aliases": ["up regulation of cell death in response to H2O2", "up regulation of cell death in response to hydrogen peroxide", "upregulation of cell death in response to H2O2", "up-regulation of cell death in response to hydrogen peroxide", "positive regulation of cell death in response to hydrogen peroxide", "upregulation of cell death in response to hydrogen peroxide", "up-regulation of cell death in response to H2O2", "positive regulation of cell death in response to H2O2"], "types": ["T044"], "canonical_name": "positive regulation of hydrogen peroxide-induced cell death", "definition": "Any process that activates or increases the frequency, rate or extent of cell death in response to hydrogen peroxide. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:20550618]"}
{"concept_id": "C4327961", "aliases": ["up regulation of connective tissue replacement", "up-regulation of connective tissue replacement", "upregulation of connective tissue replacement"], "types": ["T042"], "canonical_name": "positive regulation of connective tissue replacement", "definition": "Any process that activates or increases the frequency, rate or extent of connective tissue replacement. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961]"}
{"concept_id": "C4327962", "aliases": ["down regulation of connective tissue replacement", "downregulation of connective tissue replacement", "down-regulation of connective tissue replacement"], "types": ["T042"], "canonical_name": "negative regulation of connective tissue replacement", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of connective tissue replacement. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961]"}
{"concept_id": "C4327963", "aliases": [], "types": ["T042"], "canonical_name": "regulation of connective tissue replacement", "definition": "Any process that modulates the frequency, rate or extent of connective tissue replacement. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961]"}
{"concept_id": "C4327964", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin transmembrane transporter activity", "definition": "Enables the transfer of gibberellin from one side of a membrane to the other. [GO_REF:0000070, GOC:TermGenie, PMID:27139299]"}
{"concept_id": "C4327965", "aliases": [], "types": ["T043"], "canonical_name": "gibberellic acid transmembrane transport", "definition": "The directed movement of gibberellic acid across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:27139299]"}
{"concept_id": "C4327966", "aliases": [], "types": ["T043"], "canonical_name": "manchette disassembly", "definition": "The disaggregation of a manchette into its constituent components. [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:22319670, PMID:24440897, PMID:26792866]"}
{"concept_id": "C4327967", "aliases": ["manchette formation"], "types": ["T043"], "canonical_name": "manchette assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a manchette. [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:22319670, PMID:24440897, PMID:26792866]"}
{"concept_id": "C4327968", "aliases": ["endocannabinoid signalling pathway involved in retrograde trans-synaptic signaling by endocannabinoid"], "types": ["T044"], "canonical_name": "endocannabinoid signaling pathway involved in retrograde trans-synaptic signaling", "definition": "Any endocannabinoid signaling pathway that is involved in retrograde trans-synaptic signaling by endocannabinoid. [GO_REF:0000060, GOC:TermGenie, PMID:23040807]"}
{"concept_id": "C4327971", "aliases": ["positive regulation of chloroplast division", "up regulation of chloroplast fission", "upregulation of chloroplast division", "up regulation of chloroplast division", "upregulation of chloroplast fission", "up-regulation of chloroplast fission", "up-regulation of chloroplast division"], "types": ["T043"], "canonical_name": "positive regulation of chloroplast fission", "definition": "Any process that activates or increases the frequency, rate or extent of chloroplast fission. [GO_REF:0000058, GOC:TermGenie, PMID:26862170]"}
{"concept_id": "C4327972", "aliases": ["down-regulation of chloroplast division", "down regulation of chloroplast fission", "down-regulation of chloroplast fission", "downregulation of chloroplast division", "downregulation of chloroplast fission", "negative regulation of chloroplast division", "down regulation of chloroplast division"], "types": ["T043"], "canonical_name": "negative regulation of chloroplast fission", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of chloroplast fission. [GO_REF:0000058, GOC:TermGenie, PMID:26862170]"}
{"concept_id": "C4327973", "aliases": ["regulation of chloroplast division"], "types": ["T043"], "canonical_name": "regulation of chloroplast fission", "definition": "Any process that modulates the frequency, rate or extent of chloroplast fission. [GO_REF:0000058, GOC:TermGenie, PMID:26862170]"}
{"concept_id": "C4327974", "aliases": ["positive regulation of meiosis II metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "positive regulation of metaphase/anaphase transition of meiosis II", "definition": "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis II. [GO_REF:0000058, GOC:TermGenie, PMID:21389117]"}
{"concept_id": "C4327975", "aliases": ["negative regulation of meiosis II metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "negative regulation of metaphase/anaphase transition of meiosis II", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis II. [GO_REF:0000058, GOC:TermGenie, PMID:21389117]"}
{"concept_id": "C4327976", "aliases": ["regulation of meiosis II metaphase/anaphase transition"], "types": ["T044"], "canonical_name": "regulation of metaphase/anaphase transition of meiosis II", "definition": "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis II. [GO_REF:0000058, GOC:TermGenie, PMID:21389117]"}
{"concept_id": "C4327977", "aliases": ["positive regulation of meiosis I metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "positive regulation of metaphase/anaphase transition of meiosis I", "definition": "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I. [GO_REF:0000058, GOC:TermGenie, PMID:21389117]"}
{"concept_id": "C4327978", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of metaphase/anaphase transition of meiosis I", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis I. [GO_REF:0000058, GOC:TermGenie, PMID:21389117]"}
{"concept_id": "C4327979", "aliases": ["regulation of meiosis I metaphase/anaphase transition"], "types": ["T043"], "canonical_name": "regulation of metaphase/anaphase transition of meiosis I", "definition": "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis I. [GO_REF:0000058, GOC:TermGenie, PMID:21389117]"}
{"concept_id": "C4327981", "aliases": ["upregulation of protein serine/threonine phosphatase activity", "up regulation of serine/threonine specific protein phosphatase activity", "positive regulation of serine/threonine specific protein phosphatase activity", "up regulation of protein serine/threonine phosphatase activity", "up-regulation of protein serine/threonine phosphatase activity", "up-regulation of serine/threonine specific protein phosphatase activity", "upregulation of serine/threonine specific protein phosphatase activity"], "types": ["T044"], "canonical_name": "positive regulation of protein serine/threonine phosphatase activity", "definition": "Any process that activates or increases the frequency, rate or extent of protein serine/threonine phosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:16950131]"}
{"concept_id": "C4327982", "aliases": ["down-regulation of serine/threonine specific protein phosphatase activity", "negative regulation of serine/threonine specific protein phosphatase activity", "downregulation of serine/threonine specific protein phosphatase activity", "downregulation of protein serine/threonine phosphatase activity", "down regulation of serine/threonine specific protein phosphatase activity", "down regulation of protein serine/threonine phosphatase activity", "down-regulation of protein serine/threonine phosphatase activity"], "types": ["T044"], "canonical_name": "negative regulation of protein serine/threonine phosphatase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein serine/threonine phosphatase activity. [GO_REF:0000059, GOC:TermGenie, PMID:16950131]"}
{"concept_id": "C4327983", "aliases": ["upregulation of urease activity", "up-regulation of urea amidohydrolase activity", "up regulation of urease activity", "upregulation of urea amidohydrolase activity", "up-regulation of urease activity", "positive regulation of urea amidohydrolase activity", "up regulation of urea amidohydrolase activity"], "types": ["T044"], "canonical_name": "positive regulation of urease activity", "definition": "Any process that activates or increases the frequency, rate or extent of urease activity. [GO_REF:0000059, GOC:TermGenie, PMID:16244137]"}
{"concept_id": "C4327984", "aliases": ["regulation of urea amidohydrolase activity"], "types": ["T044"], "canonical_name": "regulation of urease activity", "definition": "Any process that modulates the frequency, rate or extent of urease activity. [GO_REF:0000059, GOC:TermGenie, PMID:16244137]"}
{"concept_id": "C4327985", "aliases": ["up regulation of cardiac muscle tissue regeneration", "up-regulation of cardiac muscle tissue regeneration", "upregulation of cardiac muscle tissue regeneration"], "types": ["T042"], "canonical_name": "positive regulation of cardiac muscle tissue regeneration", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac muscle tissue regeneration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520]"}
{"concept_id": "C4327986", "aliases": ["down-regulation of cardiac muscle tissue regeneration", "down regulation of cardiac muscle tissue regeneration", "downregulation of cardiac muscle tissue regeneration"], "types": ["T042"], "canonical_name": "negative regulation of cardiac muscle tissue regeneration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520]"}
{"concept_id": "C4327987", "aliases": [], "types": ["T042"], "canonical_name": "regulation of cardiac muscle tissue regeneration", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520]"}
{"concept_id": "C4327988", "aliases": [], "types": ["T043"], "canonical_name": "tracheary element differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a tracheary element. [GO_REF:0000086, GOC:TermGenie, PMID:20659276]"}
{"concept_id": "C4327989", "aliases": ["upregulation of vascular smooth muscle cell dedifferentiation", "up-regulation of vascular smooth muscle cell dedifferentiation", "up regulation of vascular smooth muscle cell dedifferentiation", "positive regulation of vascular smooth muscle cell dedifferentiation"], "types": ["T043"], "canonical_name": "positive regulation of vascular associated smooth muscle cell dedifferentiation", "definition": "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell dedifferentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]"}
{"concept_id": "C4327990", "aliases": ["down regulation of vascular smooth muscle cell dedifferentiation", "downregulation of vascular smooth muscle cell dedifferentiation", "negative regulation of vascular smooth muscle cell dedifferentiation", "down-regulation of vascular smooth muscle cell dedifferentiation"], "types": ["T043"], "canonical_name": "negative regulation of vascular associated smooth muscle cell dedifferentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell dedifferentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]"}
{"concept_id": "C4327991", "aliases": ["regulation of vascular smooth muscle cell dedifferentiation"], "types": ["T043"], "canonical_name": "regulation of vascular associated smooth muscle cell dedifferentiation", "definition": "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]"}
{"concept_id": "C4327992", "aliases": ["eukaryotic translation initiation factor 2B complex formation", "eIF-2B assembly", "eif2B formation", "eif2B assembly", "eIF-2B formation"], "types": ["T044"], "canonical_name": "eukaryotic translation initiation factor 2B complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2B complex. [GO_REF:0000079, GOC:TermGenie, PMID:27023709]"}
{"concept_id": "C4327993", "aliases": ["RNA-induced silencing complex binding"], "types": ["T044"], "canonical_name": "RISC complex binding", "definition": "Binding to a RISC complex. [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24882364]"}
{"concept_id": "C4327994", "aliases": ["up-regulation of protein localisation to phagosome", "up regulation of protein localisation to phagosome", "up-regulation of protein recruitment to phagosome", "positive regulation of protein recruitment to phagosome", "positive regulation of protein localisation in phagocytic vesicle", "upregulation of protein localisation to phagosome", "up regulation of protein recruitment to phagosome", "upregulation of protein localization to phagocytic vesicle", "upregulation of protein localization in phagocytic vesicle", "positive regulation of protein localisation to phagosome", "positive regulation of protein localisation to phagocytic vesicle", "up regulation of protein localization in phagocytic vesicle", "upregulation of protein recruitment to phagosome", "up-regulation of protein localization to phagocytic vesicle", "upregulation of protein localisation to phagocytic vesicle", "up regulation of protein localisation in phagocytic vesicle", "up regulation of protein localization to phagocytic vesicle", "positive regulation of protein localization in phagocytic vesicle", "up regulation of protein localisation to phagocytic vesicle", "upregulation of protein localisation in phagocytic vesicle", "up-regulation of protein localisation in phagocytic vesicle", "up-regulation of protein localization in phagocytic vesicle", "up-regulation of protein localisation to phagocytic vesicle"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to phagocytic vesicle", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to phagocytic vesicle. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671]"}
{"concept_id": "C4327995", "aliases": ["down-regulation of protein localization to phagocytic vesicle", "down regulation of protein localization to phagocytic vesicle", "down regulation of protein localisation to phagosome", "negative regulation of protein localisation to phagosome", "downregulation of protein recruitment to phagosome", "negative regulation of protein localisation in phagocytic vesicle", "down-regulation of protein localisation in phagocytic vesicle", "down regulation of protein localisation to phagocytic vesicle", "down regulation of protein localization in phagocytic vesicle", "down-regulation of protein recruitment to phagosome", "negative regulation of protein recruitment to phagosome", "negative regulation of protein localization in phagocytic vesicle", "downregulation of protein localization to phagocytic vesicle", "down regulation of protein localisation in phagocytic vesicle", "downregulation of protein localisation to phagosome", "down-regulation of protein localization in phagocytic vesicle", "down regulation of protein recruitment to phagosome", "down-regulation of protein localisation to phagocytic vesicle", "downregulation of protein localisation in phagocytic vesicle", "downregulation of protein localisation to phagocytic vesicle", "downregulation of protein localization in phagocytic vesicle", "down-regulation of protein localisation to phagosome", "negative regulation of protein localisation to phagocytic vesicle"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to phagocytic vesicle", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to phagocytic vesicle. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327996", "aliases": ["regulation of protein localization in phagocytic vesicle", "regulation of protein localisation to phagocytic vesicle", "regulation of protein localisation to phagosome", "regulation of protein localisation in phagocytic vesicle", "regulation of protein recruitment to phagosome"], "types": ["T043"], "canonical_name": "regulation of protein localization to phagocytic vesicle", "definition": "Any process that modulates the frequency, rate or extent of protein localization to phagocytic vesicle. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]"}
{"concept_id": "C4327997", "aliases": [], "types": ["T043"], "canonical_name": "ferrous iron export across plasma membrane"}
{"concept_id": "C4327998", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of supramolecular fiber organization", "definition": "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]"}
{"concept_id": "C4327999", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of supramolecular fiber organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]"}
{"concept_id": "C4328000", "aliases": [], "types": ["T043"], "canonical_name": "regulation of supramolecular fiber organization", "definition": "Any process that modulates the frequency, rate or extent of supramolecular fiber organization. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]"}
{"concept_id": "C4328001", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of non-motile cilium assembly", "definition": "Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly. [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208]"}
{"concept_id": "C4328002", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of non-motile cilium assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of non-motile cilium assembly. [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208]"}
{"concept_id": "C4328003", "aliases": [], "types": ["T043"], "canonical_name": "regulation of non-motile cilium assembly", "definition": "Any process that modulates the frequency, rate or extent of non-motile cilium assembly. [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208]"}
{"concept_id": "C4328004", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of activation of Janus kinase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK (Janus Activated Kinase) kinase activity. [GOC:TermGenie, PMID:16254138]"}
{"concept_id": "C4328005", "aliases": ["mitotic spindle assembly checkpoint silencing", "mitotic spindle assembly deactivation"], "types": ["T043"], "canonical_name": "deactivation of mitotic spindle assembly checkpoint", "definition": "A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint. [GOC:dph, GOC:TermGenie, GOC:vw, PMID:19075002, PMID:19592249]"}
{"concept_id": "C4328006", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of flagellated sperm motility", "definition": "Any process that activates or increases the frequency, rate or extent of flagellated sperm motility. [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657]"}
{"concept_id": "C4328007", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipo-chitin oligosaccharide(in) = ADP + phosphate + lipo-chitin oligosaccharide(out). [GOC:TermGenie]"}
{"concept_id": "C4328008", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of flagellated sperm motility", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility. [GOC:cilia, GOC:krc, GOC:TermGenie]"}
{"concept_id": "C4328009", "aliases": [], "types": ["T043"], "canonical_name": "regulation of flagellated sperm motility", "definition": "Any process that modulates the frequency, rate or extent of flagellated sperm motility. [GOC:cilia, GOC:krc, GOC:TermGenie]"}
{"concept_id": "C4328011", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled doxorubicin transmembrane transporter activity"}
{"concept_id": "C4328012", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled tungstate transmembrane transporter activity"}
{"concept_id": "C4328013", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell signaling by wnt", "definition": "Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the recieving cell. [GOC:dos]"}
{"concept_id": "C4328014", "aliases": ["A-to-I tRNA editing"], "types": ["T045"], "canonical_name": "tRNA adenosine deamination to inosine", "definition": "The removal of an amine group from an adenosine to produce inosine within a tRNA molecule. [PMID:27974624]"}
{"concept_id": "C4328015", "aliases": ["cnidae (plural)"], "types": ["T026"], "canonical_name": "cnida", "definition": "A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria. [Wikipedia:Cnida#Structure_and_function]"}
{"concept_id": "C4328016", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial ADP transmembrane transport", "definition": "The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:2541251]"}
{"concept_id": "C4328017", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cytoplasmic translational fidelity", "definition": "Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code. [PMID:22768388]"}
{"concept_id": "C4328019", "aliases": [], "types": ["T044"], "canonical_name": "D-aspartate transmembrane transporter activity", "definition": "Enables the transfer of D-aspartate from one side of a membrane to the other. [GO_REF:0000070, PMID:7914198]"}
{"concept_id": "C4328020", "aliases": [], "types": ["T043"], "canonical_name": "L-aspartate import across plasma membrane", "definition": "The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000069, PMID:7914198]"}
{"concept_id": "C4328022", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane bounded cell projection organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. [GOC:krc]"}
{"concept_id": "C4328023", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plasma membrane bounded cell projection organization", "definition": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. [GOC:krc]"}
{"concept_id": "C4328024", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of plasma membrane bounded cell projection assembly", "definition": "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. [GOC:krc]"}
{"concept_id": "C4328025", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of plasma membrane bounded cell projection assembly", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. [GOC:krc]"}
{"concept_id": "C4328026", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plasma membrane bounded cell projection assembly", "definition": "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly. [GOC:krc]"}
{"concept_id": "C4328027", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane bounded cell projection assembly", "definition": "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. [GOC:krc]"}
{"concept_id": "C4328028", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cilium beat frequency involved in ciliary motility", "definition": "Any process that activates or increases the frequency of cilium beating involved in ciliary motility. [PMID:28035044]"}
{"concept_id": "C4328029", "aliases": ["hydrogen ion export across plasma membrane"], "types": ["T043"], "canonical_name": "proton export across plasma membrane", "definition": "The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region. [GOC:mah, PMID:9762918]"}
{"concept_id": "C4328030", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of osmosensory signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling pathway. [GOC:vw]"}
{"concept_id": "C4328031", "aliases": [], "types": ["T043"], "canonical_name": "regulation of osmosensory signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of osmosensory signaling pathway. [GOC:vw]"}
{"concept_id": "C4328032", "aliases": ["host cell uropodium"], "types": ["T026"], "canonical_name": "host cell uropod", "definition": "A host cell membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively. [PMID:24965475]"}
{"concept_id": "C4328033", "aliases": [], "types": ["T026"], "canonical_name": "plasma membrane bounded cell projection", "definition": "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. [GOC:krc]"}
{"concept_id": "C4328034", "aliases": [], "types": ["T044"], "canonical_name": "glucagon-like peptide binding"}
{"concept_id": "C4328035", "aliases": [], "types": ["T044"], "canonical_name": "somatostatin binding", "definition": "Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin. [GOC:cvs, PMID:20472043]"}
{"concept_id": "C4328036", "aliases": [], "types": ["T044"], "canonical_name": "glucagon binding"}
{"concept_id": "C4328037", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane cholesterol transfer activity"}
{"concept_id": "C4328038", "aliases": ["phosphatidylcholine carrier activity"], "types": ["T044"], "canonical_name": "phosphatidylcholine transfer activity", "definition": "Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C4328039", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane phosphotidylinositol transfer activity"}
{"concept_id": "C4328040", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane ceramide transfer activity"}
{"concept_id": "C4328041", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane sphingolipid transfer activity"}
{"concept_id": "C4328042", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane sterol transfer activity"}
{"concept_id": "C4328043", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane phospholipid transfer activity"}
{"concept_id": "C4328044", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane lipid transfer activity"}
{"concept_id": "C4328045", "aliases": [], "types": ["T043"], "canonical_name": "intermembrane sphingolipid transfer", "definition": "The transport of sphingolipids between membranes in which a sphingolipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs). [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C4328046", "aliases": [], "types": ["T043"], "canonical_name": "intermembrane sterol transfer", "definition": "The transport of sterols between membranes in which a sterol molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs). [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C4328047", "aliases": [], "types": ["T043"], "canonical_name": "intermembrane phospholipid transfer", "definition": "The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C4328048", "aliases": [], "types": ["T043"], "canonical_name": "intermembrane lipid transfer", "definition": "The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs). [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C4328049", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glutamatergic neuron differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation. [PMID:24030726]"}
{"concept_id": "C4328050", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glutamatergic neuron differentiation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation. [PMID:24030726]"}
{"concept_id": "C4328051", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glutamatergic neuron differentiation", "definition": "Any process that modulates the frequency, rate or extent of glutamatergic neuron differentiation. [PMID:24030726]"}
{"concept_id": "C4328052", "aliases": [], "types": ["T029"], "canonical_name": "hinge region between urothelial plaques of apical plasma membrane", "definition": "A narrow rim of non-thickened membrane in between urothelial plaques in apical plasma membrane. [GOC:krc, PMID:21468280, PMID:21887288]"}
{"concept_id": "C4328053", "aliases": [], "types": ["T026"], "canonical_name": "fusiform vesicle", "definition": "A cytoplasmic vesicle which contains two urothelial plaques and can deliver these plaques to the apical plasma membrane of urothelial superficial (umbrella) cells. It can also be formed by endocytosis of apical plasma membrane during contractions of the urinary bladder. [GOC:krc, PMID:21468280, PMID:21887288]"}
{"concept_id": "C4328054", "aliases": [], "types": ["T043"], "canonical_name": "regulation of basement membrane organization", "definition": "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. [GOC:ha, PMID:27404358]"}
{"concept_id": "C4328055", "aliases": [], "types": ["T043"], "canonical_name": "basolateral protein secretion", "definition": "The controlled release of proteins from a cell at the sides which interface adjacent cells and near the base. [GOC:ha, PMID:27404358]"}
{"concept_id": "C4328056", "aliases": [], "types": ["T043"], "canonical_name": "formin-nucleated actin cable organization", "definition": "A process that results in the assembly, arrangement of constituent parts, or disassembly of a formin-nucleated actin cable. [GOC:mah]"}
{"concept_id": "C4328057", "aliases": [], "types": ["T045"], "canonical_name": "ncRNA deadenylation", "definition": "Shortening of the poly(A) tail of a nuclear-transcribed ncRNA. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:26950371]"}
{"concept_id": "C4328058", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of tRNA C5-cytosine methylation", "definition": "Any process that activates or increases the frequency, rate or extent of tRNA C5-cytosine methylation. [GOC:vw, PMID:23074192]"}
{"concept_id": "C4328059", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of tRNA methylation", "definition": "Any process that activates or increases the frequency, rate or extent of tRNA methylation. [GOC:vw, PMID:23074192]"}
{"concept_id": "C4328060", "aliases": [], "types": ["T045"], "canonical_name": "regulation of tRNA C5-cytosine methylation", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA C5-cytosine methylation. [GOC:vw, PMID:23074192]"}
{"concept_id": "C4328061", "aliases": [], "types": ["T045"], "canonical_name": "regulation of tRNA methylation", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation. [GOC:vw, PMID:23074192]"}
{"concept_id": "C4328062", "aliases": [], "types": ["T046"], "canonical_name": "positive regulation of inflammatory response to wounding", "definition": "Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821]"}
{"concept_id": "C4328063", "aliases": [], "types": ["T046"], "canonical_name": "negative regulation of inflammatory response to wounding", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821]"}
{"concept_id": "C4328064", "aliases": [], "types": ["T046"], "canonical_name": "regulation of inflammatory response to wounding", "definition": "Any process that modulates the frequency, rate or extent of the inflammatory response to wounding. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821]"}
{"concept_id": "C4328065", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of protein localization to cell cortex of cell tip", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the cell cortex of the cell tip. [GOC:vw, PMID:19474792]"}
{"concept_id": "C4328066", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein localization to medial cortex", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to the medial cortex. [GOC:hjd, PMID:19474789]"}
{"concept_id": "C4328067", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein localization to medial cortex", "definition": "Any process that regulates the localization of a protein to the medial cortex. [GOC:hjd]"}
{"concept_id": "C4328068", "aliases": [], "types": ["T044"], "canonical_name": "(4S)-4-hydroxy-2-oxoglutarate aldolase activity", "definition": "Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. [EC:4.1.3.42, GOC:hjd, PMID:1098660, PMID:1339418]"}
{"concept_id": "C4328069", "aliases": [], "types": ["T044"], "canonical_name": "2-oxoglutaramate amidase activity", "definition": "Catalysis of the reaction: 2-oxoglutaramate + H(2)O = 2-oxoglutarate + NH(3). [EC:3.5.1.111, PMID:21288482]"}
{"concept_id": "C4328070", "aliases": [], "types": ["T043"], "canonical_name": "microtubule anchoring at cell cortex of cell tip", "definition": "Any process in which a microtubule is maintained in a specific location at the cell tip by attachment to the cell cortex. [GOC:mah, PMID:25736293]"}
{"concept_id": "C4328071", "aliases": [], "types": ["T044"], "canonical_name": "microtubule cortical anchor activity"}
{"concept_id": "C4328072", "aliases": [], "types": ["T045"], "canonical_name": "RNA 5'-cap (guanine-N7)-methylation", "definition": "The process whereby a guanine in 5-cap is methylated at the N7 position of guanine. [GOC:hjd]"}
{"concept_id": "C4328073", "aliases": [], "types": ["T045"], "canonical_name": "tRNA (guanine-N7)-methylation", "definition": "The process whereby a guanine in a tRNA is methylated at the N7 position of guanine. [GOC:hjd, PMID:17382321]"}
{"concept_id": "C4328074", "aliases": [], "types": ["T043"], "canonical_name": "intestinal hexose absorption", "definition": "Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine. [GOC:hjd]"}
{"concept_id": "C4328075", "aliases": [], "types": ["T044"], "canonical_name": "methylthiohexylmalate dehydrogenase activity", "definition": "Catalysis of the reaction: 3-(6'-methylthio)hexylmalate <=> H+ + 2-oxo-9-methylthiononanoate + carbon dioxide. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328076", "aliases": [], "types": ["T044"], "canonical_name": "methylthiohexylmalate isomerase activity", "definition": "Catalysis of the reaction: 2-(6'-methylthio)hexylmalate <=> 3-(6'-methylthio)hexylmalate. [EC:5.4.4.-, GOC:pz]"}
{"concept_id": "C4328077", "aliases": [], "types": ["T044"], "canonical_name": "methylthiopentylmalate dehydrogenase activity", "definition": "Catalysis of the reaction: 3-(5'-methylthio)pentylmalate <=> H+ + 2-oxo-8-methylthiooctanoate + carbon dioxide. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328078", "aliases": [], "types": ["T044"], "canonical_name": "methylthiopentylmalate isomerase activity", "definition": "Catalysis of the reaction: 2-(5'-methylthio)pentylmalate <=> 3-(5'-methylthio)pentylmalate. [EC:5.4.4.-, GOC:pz]"}
{"concept_id": "C4328079", "aliases": [], "types": ["T044"], "canonical_name": "methylthiobutylmalate dehydrogenase activity", "definition": "Catalysis of the reaction: 3-(4'-methylthio)butylmalate <=> H+ + 2-oxo-7-methylthioheptanoate + carbon dioxide. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328080", "aliases": [], "types": ["T044"], "canonical_name": "methylthiobutylmalate isomerase activity", "definition": "Catalysis of the reaction: 2-(4'-methylthio)butylmalate <=> 3-(4'-methylthio)butylmalate. [EC:5.4.4.-, GOC:pz]"}
{"concept_id": "C4328081", "aliases": [], "types": ["T044"], "canonical_name": "methylthiopropylmalate dehydrogenase activity", "definition": "Catalysis of the reaction: 3-(3'-methylthio)propylmalate <=> H+ + 2-oxo-6-methylthiohexanoate + carbon dioxide. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328082", "aliases": [], "types": ["T044"], "canonical_name": "methylthiopropylmalate isomerase activity", "definition": "Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) <=> 3-(3'-methylthio)propylmalate. [EC:5.4.4.-, GOC:pz]"}
{"concept_id": "C4328083", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity", "definition": "Catalysis of the reaction: a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA <=> formyl-CoA + a 2-methyl branched 2,3,4-saturated fatty aldehyde. [EC:4.1.-.-, GOC:pz]"}
{"concept_id": "C4328087", "aliases": [], "types": ["T044"], "canonical_name": "isobutyraldehyde reductase activity", "definition": "Catalysis of the reaction: isobutanol + NADP <=> isobutyraldehyde + NADPH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328088", "aliases": [], "types": ["T044"], "canonical_name": "tRNA m2A37 methyltransferase activity", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + an adenine37 in tRNA <=> S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-methyladenine37 in tRNA. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328089", "aliases": [], "types": ["T044"], "canonical_name": "alanylglutamate dipeptidase activity", "definition": "Catalysis of the reaction: L-alanyl-L-glutamate + H2O <=> L-alanine + L-glutamate. [EC:3.4.13.18, GOC:pz]"}
{"concept_id": "C4328090", "aliases": [], "types": ["T044"], "canonical_name": "5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity", "definition": "Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> H+ + alpha-D-ribose 1,5-bisphosphate. [EC:3.1.4.55, GOC:pz]"}
{"concept_id": "C4328091", "aliases": [], "types": ["T044"], "canonical_name": "NADH:menaquinone oxidoreductase activity", "definition": "Catalysis of the reaction: 5 H+ + NADH + a menaquinone <=> 4 H+ + NAD + a menaquinol. [GOC:pz]"}
{"concept_id": "C4328092", "aliases": [], "types": ["T044"], "canonical_name": "fructose-1-phosphatase activity", "definition": "Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O <=> beta-D-fructofuranose + hydrogenphosphate. [EC:3.1.3.-, GOC:pz]"}
{"concept_id": "C4328094", "aliases": [], "types": ["T044"], "canonical_name": "ITPase activity", "definition": "Catalysis of the reaction: ITP + H2O <=> H+ + IDP + hydrogenphosphate. [GOC:pz, PMID:16216582, RHEA:28330]"}
{"concept_id": "C4328095", "aliases": [], "types": ["T044"], "canonical_name": "1-deoxy-D-xylulose kinase activity", "definition": "Catalysis of the reaction: 1-deoxy-D-xylulose + ATP <=> H+ + 1-deoxy-D-xylulose 5-phosphate + ADP. [GOC:pz, PMID:11168365, PMID:16920870]"}
{"concept_id": "C4328096", "aliases": [], "types": ["T044"], "canonical_name": "3-chlorotoluene monooxygenase activity", "definition": "Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 <=> 3-chlorobenzyl alcohol + NAD + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328097", "aliases": [], "types": ["T044"], "canonical_name": "4-chloro-2-methylphenoxyacetate oxygenase activity", "definition": "Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 <=> 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328098", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetate carboxyl methyltransferase activity", "definition": "Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine. [EC:2.1.1.278, GOC:pz]"}
{"concept_id": "C4328099", "aliases": [], "types": ["T044"], "canonical_name": "9,10-dihydroxystearate hydroxylase activity", "definition": "Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH <=> 9,10,18-trihydroxystearate + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328100", "aliases": [], "types": ["T044"], "canonical_name": "9,10-epoxystearate hydroxylase activity", "definition": "Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH <=> 9,10-epoxy-18-hydroxystearate + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328101", "aliases": [], "types": ["T044"], "canonical_name": "oleate peroxygenase activity", "definition": "Catalysis of the reaction: oleate + a lipid hydroperoxide <=> 9,10-epoxystearate + a lipid alcohol. [EC:1.11.-.-, GOC:pz]"}
{"concept_id": "C4328102", "aliases": [], "types": ["T044"], "canonical_name": "16-hydroxypalmitate dehydrogenase activity", "definition": "Catalysis of the reaction: 16-hydroxypalmitate + NADP <=> H+ + 16-oxo-palmitate + NADPH. [GOC:pz]"}
{"concept_id": "C4328103", "aliases": [], "types": ["T044"], "canonical_name": "dimethylsulfoxide oxygenase activity", "definition": "Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ <=> sulfonyldimethane + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328104", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 4-hydroxylamino-2,6-dinitrotoluene <=> 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328105", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene <=> 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328106", "aliases": [], "types": ["T044"], "canonical_name": "4-sulfomuconolactone hydrolase activity", "definition": "Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O <=> maleylacetate + sulfite + 2 H+. [EC:3.1.1.92, GOC:pz]"}
{"concept_id": "C4328107", "aliases": [], "types": ["T044"], "canonical_name": "progesterone 5beta- reductase activity", "definition": "Catalysis of the reaction: H+ + progesterone + NADPH <=> 5beta-pregnane-3,20-dione + NADP. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4328108", "aliases": [], "types": ["T044"], "canonical_name": "beta,beta digalactosyldiacylglycerol galactosyltransferase activity", "definition": "Catalysis of the reaction: a 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + a beta,beta digalactosyldiacylglycerol <=> a trigalactosyldiacylglycerol + a 1,2-diacyl-sn-glycerol. [EC:2.4.1.184, GOC:pz]"}
{"concept_id": "C4328109", "aliases": [], "types": ["T044"], "canonical_name": "angelicin synthase activity", "definition": "Catalysis of the reaction: columbianetin + NADPH + O2 + H+ <=> angelicin + acetone + NADP + 2 H2O. [EC:1.14.14.148, GOC:pz]"}
{"concept_id": "C4328110", "aliases": [], "types": ["T044"], "canonical_name": "linolenate delta15 desaturase activity", "definition": "Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328111", "aliases": [], "types": ["T044"], "canonical_name": "2-methylbutyronitrile hydroxylase activity", "definition": "Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 <=> H2O + NADP + 2-hydroxy-2-methylbutyronitrile. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328112", "aliases": [], "types": ["T044"], "canonical_name": "myristoyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A. [EC:3.1.2.2, GOC:pz]"}
{"concept_id": "C4328113", "aliases": [], "types": ["T044"], "canonical_name": "5-n-alk(en)ylresorcinol O-methyltransferase activity", "definition": "Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328114", "aliases": [], "types": ["T044"], "canonical_name": "5-pentadecatrienylresorcinol synthase activity", "definition": "Catalysis of the reaction: 3 H+ + 9,12,15-cis-hexadecatrienoyl-CoA + 3 malonyl-CoA(5-) <=> 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + 4 coenzyme A + 4 carbon dioxide. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328115", "aliases": [], "types": ["T044"], "canonical_name": "9,12-cis-hexadecadienoic acid delta 15 desaturase activity", "definition": "Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor <=> 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328116", "aliases": [], "types": ["T044"], "canonical_name": "palmitoleic acid delta 12 desaturase activity", "definition": "Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328117", "aliases": [], "types": ["T044"], "canonical_name": "delta12-fatty-acid desaturase activity", "definition": "Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor <=> linoleoyl-CoA + 2 H2O + an oxidized electron acceptor. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. [GOC:pz, RHEA:25856]"}
{"concept_id": "C4328118", "aliases": [], "types": ["T044"], "canonical_name": "sulfoacetaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: sulfonatoacetaldehyde + H2O + NAD <=> sulfonatoacetate + NADH + 2 H+. [EC:1.2.1.73, GOC:pz]"}
{"concept_id": "C4328119", "aliases": [], "types": ["T044"], "canonical_name": "xylogalacturonan beta-1,3-xylosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan <=> UDP + 4 H+ + a xylogalacturonan. [EC:2.4.2.41, GOC:pz]"}
{"concept_id": "C4328120", "aliases": [], "types": ["T044"], "canonical_name": "UDP-3-dehydro-alpha-D-glucose dehydrogenase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + NAD <=> H+ + UDP-3-keto-alpha-D-glucose + NADH. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328121", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity", "definition": "Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP <=> (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4328122", "aliases": [], "types": ["T044"], "canonical_name": "2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity", "definition": "Catalysis of the reaction: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP <=> (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4328123", "aliases": [], "types": ["T044"], "canonical_name": "homofuraneol oxidoreductase activity", "definition": "Catalysis of the reaction: homofuraneol + NADP <=> (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4328124", "aliases": [], "types": ["T044"], "canonical_name": "furaneol oxidoreductase activity", "definition": "Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP <=> 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+. [EC:1.3.1.105, GOC:pz]"}
{"concept_id": "C4328125", "aliases": [], "types": ["T044"], "canonical_name": "versiconal reductase activity", "definition": "Catalysis of the reaction: versiconol + NADP <=> versiconal hemiacetal + NADPH + H+. [EC:1.1.1.353, GOC:pz]"}
{"concept_id": "C4328126", "aliases": [], "types": ["T044"], "canonical_name": "versiconal hemiacetal acetate reductase activity", "definition": "Catalysis of the reaction: versiconol acetate + NADP <=> versiconal hemiacetal acetate + NADPH. [EC:1.1.1.353, GOC:pz]"}
{"concept_id": "C4328127", "aliases": [], "types": ["T044"], "canonical_name": "phosphinothricin N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + phosphinothricin <=> H+ + coenzyme A(4-) + N-acetylphosphinatothricinate. [EC:2.3.1.183, GOC:pz]"}
{"concept_id": "C4328128", "aliases": [], "types": ["T044"], "canonical_name": "7-deoxyloganetic acid glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate <=> H+ + 7-deoxyloganate + UDP. [EC:2.4.1.323, GOC:pz]"}
{"concept_id": "C4328129", "aliases": [], "types": ["T044"], "canonical_name": "10-hydroxygeranial oxidoreductase activity", "definition": "Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP <=> (6E)-8-oxogeranial + NADPH + H+. [GOC:pz, RHEA:32611]"}
{"concept_id": "C4328130", "aliases": [], "types": ["T044"], "canonical_name": "10-hydroxygeraniol oxidoreductase activity", "definition": "Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP <=> (6E)-8-hydroxygeranial + NADPH + H+. [GOC:pz, RHEA:32607]"}
{"concept_id": "C4328131", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity", "definition": "Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine <=> H+ + magnoflorine + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328132", "aliases": [], "types": ["T044"], "canonical_name": "(S)-corytuberine synthase activity", "definition": "Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O. [GOC:pz, PMID:18230623, RHEA:51540]"}
{"concept_id": "C4328133", "aliases": [], "types": ["T044"], "canonical_name": "dalcochinase activity", "definition": "Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O <=> dalcochinin + D-glucopyranose. [GOC:pz, PMID:16814564]"}
{"concept_id": "C4328134", "aliases": [], "types": ["T044"], "canonical_name": "(+)-delta-cadinene-8-hydroxylase activity", "definition": "Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O. [GOC:pz]"}
{"concept_id": "C4328135", "aliases": [], "types": ["T044"], "canonical_name": "soyasapogenol E UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E <=> UDP + a soyasapogenol E monoglucoside. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328136", "aliases": [], "types": ["T044"], "canonical_name": "soyasapogenol B UDP-glucosyl transferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B <=> UDP(3-) + a soyasapogenol B monoglucoside. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328137", "aliases": [], "types": ["T044"], "canonical_name": "medicagenate UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate <=> UDP(3-) + a medicagenate monoglucoside. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328138", "aliases": [], "types": ["T044"], "canonical_name": "mannosylglycerate synthase activity", "definition": "Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate <=> H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP. [EC:2.4.1.269, GOC:pz]"}
{"concept_id": "C4328139", "aliases": [], "types": ["T044"], "canonical_name": "acyl coenzyme A: isopenicillin N acyltransferase activity", "definition": "Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O <=> H+ + coenzyme A + penicillin K + L-2-aminoadipate. [EC:2.3.1.164, GOC:pz]"}
{"concept_id": "C4328140", "aliases": [], "types": ["T044"], "canonical_name": "5,6-dimethylbenzimidazole synthase activity", "definition": "Catalysis of the reaction: FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid. [EC:1.13.11.79, GOC:pz]"}
{"concept_id": "C4328141", "aliases": [], "types": ["T044"], "canonical_name": "(R)-reticuline 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: (R)-reticulinium(1+) + S-adenosyl-L-methionine <=> (R)-laudanine(1+) + S-adenosyl-L-homocysteine + H+. [GOC:pz, RHEA:38907]"}
{"concept_id": "C4328142", "aliases": [], "types": ["T044"], "canonical_name": "(S)-reticuline 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: (S)-reticulinium(1+) + S-adenosyl-L-methionine <=> H+ + laudanine(1+) + S-adenosyl-L-homocysteine. [GOC:pz, RHEA:10444]"}
{"concept_id": "C4328143", "aliases": [], "types": ["T044"], "canonical_name": "sesamin synthase activity", "definition": "Catalysis of the reaction: H+ + (+)-piperitol + NADPH + O2 <=> (+)-sesamin + NADP + 2 H2O. [GOC:pz, PMID:16785429]"}
{"concept_id": "C4328144", "aliases": [], "types": ["T044"], "canonical_name": "piperitol synthase activity", "definition": "Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 <=> (+)-piperitol + NADP + 2 H2O. [GOC:pz, PMID:16785429, RHEA:56776]"}
{"concept_id": "C4328145", "aliases": [], "types": ["T044"], "canonical_name": "(-)-lactol dehydrogenase activity", "definition": "Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH. [EC:1.1.1.331, GOC:pz]"}
{"concept_id": "C4328146", "aliases": [], "types": ["T044"], "canonical_name": "(-)-secoisolariciresinol dehydrogenase activity", "definition": "Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH. [EC:1.1.1.331, GOC:pz]"}
{"concept_id": "C4328147", "aliases": [], "types": ["T044"], "canonical_name": "dirigent protein activity", "definition": "Catalysis of the reaction: 2 H+ + 2 coniferol + O2 <=> (+)-pinoresinol + 2 H2O. [EC:1.10.3.-, GOC:pz]"}
{"concept_id": "C4328148", "aliases": [], "types": ["T044"], "canonical_name": "sesquisabinene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + sesquisabinene. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328149", "aliases": [], "types": ["T044"], "canonical_name": "7-epi-alpha-selinene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (-)-7-epi-alpha-selinene + diphosphoric acid. [EC:4.2.3.86, GOC:pz]"}
{"concept_id": "C4328150", "aliases": [], "types": ["T044"], "canonical_name": "valencene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (+)-valencene + diphosphoric acid. [EC:4.2.3.73, GOC:pz]"}
{"concept_id": "C4328151", "aliases": [], "types": ["T044"], "canonical_name": "isopimaradienal hydroxylase activity", "definition": "Catalysis of the reaction: isopimaradienal + NADPH + O2 <=> isopimaric acid + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328152", "aliases": [], "types": ["T044"], "canonical_name": "isopimaradienol hydroxylase activity", "definition": "Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 <=> isopimaradiene-diol + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328153", "aliases": [], "types": ["T044"], "canonical_name": "dehydroabietadienal hydroxylase activity", "definition": "Catalysis of the reaction: dehydroabietadienal + NADPH + O2 <=> dehydroabietic acid + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328154", "aliases": [], "types": ["T044"], "canonical_name": "dehydroabietadienol hydroxylase activity", "definition": "Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 <=> dehydroabietadiene-diol + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328155", "aliases": [], "types": ["T044"], "canonical_name": "levopimaradienol hydroxylase activity", "definition": "Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 <=> levopiramadiene-diol + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328156", "aliases": [], "types": ["T044"], "canonical_name": "abietadienal hydroxylase activity", "definition": "Catalysis of the reaction: abietal + NADPH + O2 <=> abietate + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328157", "aliases": [], "types": ["T044"], "canonical_name": "colnelenate synthase activity", "definition": "Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate <=> colnelenate + H2O. [EC:4.2.1.121, GOC:pz]"}
{"concept_id": "C4328158", "aliases": [], "types": ["T044"], "canonical_name": "colneleate synthase activity", "definition": "Catalysis of the reaction: 9(S)-HPODE <=> colneleate + H2O. [EC:4.2.1.121, GOC:pz]"}
{"concept_id": "C4328159", "aliases": [], "types": ["T044"], "canonical_name": "UDPG:cyclo-DOPA 5-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome <=> H+ + cyclo-dopa 5-O-glucoside + UDP. [GOC:pz, PMID:15196939, PMID:15695438]"}
{"concept_id": "C4328160", "aliases": [], "types": ["T044"], "canonical_name": "betanidin 6-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + gomphrenin I + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328161", "aliases": [], "types": ["T044"], "canonical_name": "betanidin 5-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + betanin + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328162", "aliases": [], "types": ["T044"], "canonical_name": "2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone <=> H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP. [EC:2.4.1.286, GOC:pz]"}
{"concept_id": "C4328163", "aliases": [], "types": ["T044"], "canonical_name": "naringenin chalcone 4'-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone <=> UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+. [EC:2.4.1.286, GOC:pz]"}
{"concept_id": "C4328164", "aliases": [], "types": ["T044"], "canonical_name": "beta-elemene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-elemene + diphosphoric acid. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328165", "aliases": [], "types": ["T044"], "canonical_name": "delta-cuprenene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> delta-cuprenene + diphosphoric acid. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328166", "aliases": [], "types": ["T044"], "canonical_name": "beta-sesquiphellandrene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphoric acid. [EC:4.2.3.123, GOC:pz]"}
{"concept_id": "C4328167", "aliases": [], "types": ["T044"], "canonical_name": "alpha-chamigrene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-chamigrene + diphosphoric acid. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328168", "aliases": [], "types": ["T044"], "canonical_name": "alpha-cuprenene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphoric acid. [EC:4.2.3.95, GOC:pz]"}
{"concept_id": "C4328169", "aliases": [], "types": ["T044"], "canonical_name": "alpha-zingiberene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> zingiberene + diphosphoric acid. [EC:4.2.3.65, GOC:pz]"}
{"concept_id": "C4328170", "aliases": [], "types": ["T044"], "canonical_name": "(+)-beta-chamigrene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphoric acid. [EC:4.2.3.78, GOC:pz]"}
{"concept_id": "C4328171", "aliases": [], "types": ["T044"], "canonical_name": "beta-acoradiene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-acoradiene + diphosphoric acid. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328172", "aliases": [], "types": ["T044"], "canonical_name": "(+)-beta-barbatene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid. [GOC:pz, PMID:15918888, PMID:16297850]"}
{"concept_id": "C4328173", "aliases": [], "types": ["T044"], "canonical_name": "isobazzanene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> isobazzanene + diphosphoric acid. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328174", "aliases": [], "types": ["T044"], "canonical_name": "(+)-thujopsene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-thujopsene + diphosphoric acid. [GOC:pz, RHEA:30375]"}
{"concept_id": "C4328175", "aliases": [], "types": ["T044"], "canonical_name": "(+)-alpha-barbatene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphoric acid. [EC:4.2.3.69, GOC:pz]"}
{"concept_id": "C4328176", "aliases": [], "types": ["T044"], "canonical_name": "alpha-copaene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-copaene + diphosphoric acid. [EC:4.2.3.133, GOC:pz]"}
{"concept_id": "C4328177", "aliases": [], "types": ["T044"], "canonical_name": "psoralen synthase activity", "definition": "Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 <=> psoralen + NADP + acetone + 2 H2O. [EC:1.14.14.141, GOC:pz]"}
{"concept_id": "C4328178", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328179", "aliases": [], "types": ["T044"], "canonical_name": "1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, PMID:17064923]"}
{"concept_id": "C4328180", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, PMID:7948918, PMID:8066133]"}
{"concept_id": "C4328181", "aliases": [], "types": ["T044"], "canonical_name": "1-16:0-2-18:2-phosphatidylcholine desaturase activity", "definition": "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [GOC:pz, PMID:15538555, PMID:8102138]"}
{"concept_id": "C4328182", "aliases": [], "types": ["T044"], "canonical_name": "1-16:0-2-18:1-phosphatidylcholine desaturase activity", "definition": "Catalysis of the reaction: 1-16:0-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-palmitoyl-2-linoleoyl-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [GOC:pz, PMID:475773]"}
{"concept_id": "C4328183", "aliases": [], "types": ["T044"], "canonical_name": "7-hydroxyflavone-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone <=> 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328184", "aliases": [], "types": ["T044"], "canonical_name": "6-hydroxyflavone-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone <=> 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328185", "aliases": [], "types": ["T044"], "canonical_name": "24-epi-campsterol desaturase activity", "definition": "Catalysis of the reaction: 24-epi-campesterol + NADPH + H+ + O2 <=> brassicasterol + NADP + 2 H2O. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4328186", "aliases": [], "types": ["T044"], "canonical_name": "molybdenum cofactor sulfurtransferase activity", "definition": "Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O. [EC:2.8.1.9, GOC:pz]"}
{"concept_id": "C4328187", "aliases": [], "types": ["T044"], "canonical_name": "di-homo-gamma-linolenate delta5 desaturase activity", "definition": "Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor <=> arachidonate + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328188", "aliases": [], "types": ["T044"], "canonical_name": "delta6-acyl-lipid desaturase activity", "definition": "Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. [GOC:pz, PMID:10848999, RHEA:46536]"}
{"concept_id": "C4328189", "aliases": [], "types": ["T044"], "canonical_name": "1-18:3-2-18:2-phosphatidylcholine desaturase activity", "definition": "Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328190", "aliases": [], "types": ["T044"], "canonical_name": "1-18:3-2-18:1-phosphatidylcholine desaturase activity", "definition": "Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328191", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-18:2-phosphatidylcholine synthase activity", "definition": "Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:1-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328192", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-18:3-phosphatidylcholine desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328193", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-18:3-phosphatidylcholinedesaturase activity", "definition": "Catalysis of the reaction: 1-18:1-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328194", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328195", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-18:2-phosphatidylcholine desaturase activity", "definition": "Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + 2 H2O + an oxidized electron acceptor. [GOC:pz, RHEA:46332]"}
{"concept_id": "C4328196", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-18:1-phosphatidylcholine desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328197", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity", "definition": "Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328198", "aliases": [], "types": ["T044"], "canonical_name": "1-18:3-2-16:0-phosphatidylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:3-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328199", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-16:0-phosphatidylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328200", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity", "definition": "Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, RHEA:46376]"}
{"concept_id": "C4328201", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328202", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328203", "aliases": [], "types": ["T044"], "canonical_name": "1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328204", "aliases": [], "types": ["T044"], "canonical_name": "1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:3-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328205", "aliases": [], "types": ["T044"], "canonical_name": "1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328206", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity", "definition": "Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, PMID:11607123]"}
{"concept_id": "C4328207", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-16:3-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328208", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328209", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328210", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328211", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity", "definition": "Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, PMID:7948918]"}
{"concept_id": "C4328212", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328213", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity", "definition": "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, PMID:7948918, PMID:8066133]"}
{"concept_id": "C4328214", "aliases": [], "types": ["T044"], "canonical_name": "sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity", "definition": "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> D-galactosylononitol + myo-inositol. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328215", "aliases": [], "types": ["T044"], "canonical_name": "verbascose galactinol:ajugose galactosyltransferase activity", "definition": "Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> ajugose + myo-inositol. [GOC:pz, PMID:11675396]"}
{"concept_id": "C4328216", "aliases": [], "types": ["T044"], "canonical_name": "verbascose synthase activity", "definition": "Catalysis of the reaction: 2 stachyose <=> verbascose + raffinose. [GOC:pz, PMID:12060258]"}
{"concept_id": "C4328217", "aliases": [], "types": ["T044"], "canonical_name": "ajugose synthase activity", "definition": "Catalysis of the reaction: 2 verbascose <=> ajugose + stachyose. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328218", "aliases": [], "types": ["T044"], "canonical_name": "stachyose galactinol:verbascose galactosyltransferase activity", "definition": "Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> verbascose + myo-inositol. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328219", "aliases": [], "types": ["T044"], "canonical_name": "kaempferol-3-glucoside-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside <=> kaempferol 3,7-O-diglucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328220", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3-O-rhamnoside-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside <=> quercetin 3-O-rhamnoside-7-O-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328221", "aliases": [], "types": ["T044"], "canonical_name": "UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose <=> H+ + quercetin 3-O-rhamnoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328222", "aliases": [], "types": ["T044"], "canonical_name": "kaempferol-3-rhamnoside-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol-3-rhamnoside <=> kaempferol 3-O-rhamnoside-7-O-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328223", "aliases": [], "types": ["T044"], "canonical_name": "bixin methyltransferase activity", "definition": "Catalysis of the reaction: bixin + S-adenosyl-L-methionine <=> bixin dimethyl ester + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328224", "aliases": [], "types": ["T044"], "canonical_name": "norbixin methyltransferase activity", "definition": "Catalysis of the reaction: norbixin + S-adenosyl-L-methionine <=> bixin + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328225", "aliases": [], "types": ["T044"], "canonical_name": "bixin aldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: bixin aldehyde + O2 + NAD <=> norbixin + NADH + H+. [EC:1.2.1.-, GOC:pz]"}
{"concept_id": "C4328226", "aliases": [], "types": ["T044"], "canonical_name": "lycopene cleavage oxygenase activity", "definition": "Catalysis of the reaction: lycopene + 2 O2 <=> 2 sulcatone + bixin aldehyde. [EC:1.13.12.-, GOC:pz]"}
{"concept_id": "C4328227", "aliases": [], "types": ["T044"], "canonical_name": "caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA <=> gentiodelphin + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328228", "aliases": [], "types": ["T044"], "canonical_name": "UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside <=> H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP. [EC:2.4.1.298, GOC:pz]"}
{"concept_id": "C4328229", "aliases": [], "types": ["T044"], "canonical_name": "caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + coenzyme A. [EC:2.3.1.153, GOC:pz]"}
{"concept_id": "C4328230", "aliases": [], "types": ["T044"], "canonical_name": "caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328231", "aliases": [], "types": ["T044"], "canonical_name": "4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "definition": "Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328232", "aliases": [], "types": ["T044"], "canonical_name": "geraniol 10-hydroxylase activity", "definition": "Catalysis of the reaction: geraniol + O2 + NADPH + H+ <=> (6E)-8-hydroxygeraniol + NADP + H2O. [EC:1.14.14.83, GOC:pz]"}
{"concept_id": "C4328233", "aliases": [], "types": ["T044"], "canonical_name": "delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-beta-D-glucoside <=> H+ + delphinidin 3-O-sophoroside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328234", "aliases": [], "types": ["T044"], "canonical_name": "pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside <=> H+ + pelargonidin 3-O-sophoroside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328235", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-O-sophoroside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328236", "aliases": [], "types": ["T044"], "canonical_name": "4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity", "definition": "Catalysis of the reaction: 4-coumaryl-CoA + cyanin betaine <=> shisonin + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328237", "aliases": [], "types": ["T044"], "canonical_name": "codeine O-demethylase activity", "definition": "Catalysis of the reaction: codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + carbon dioxide. [EC:1.14.11.32, GOC:pz]"}
{"concept_id": "C4328238", "aliases": [], "types": ["T044"], "canonical_name": "oripavine 6-O-demethylase activity", "definition": "Catalysis of the reaction: oripavine + 2-oxoglutarate + O2 <=> morphinone + formaldehyde + succinate + carbon dioxide. [EC:1.14.11.31, GOC:pz]"}
{"concept_id": "C4328239", "aliases": [], "types": ["T044"], "canonical_name": "thebane O-demethylase activity", "definition": "Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> oripavine + formaldehyde + succinate + carbon dioxide. [EC:1.14.11.32, GOC:pz]"}
{"concept_id": "C4328240", "aliases": [], "types": ["T044"], "canonical_name": "thebaine 6-O-demethylase activity", "definition": "Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> neopinone + formaldehyde + succinate + carbon dioxide. [EC:1.14.11.31, GOC:pz]"}
{"concept_id": "C4328241", "aliases": [], "types": ["T044"], "canonical_name": "protocatechualdehyde:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: 3,4-dihydroxybenzaldehyde + O2 + H2O <=> H+ + 3,4-dihydroxybenzoate + hydrogen peroxide. [EC:1.2.3.9, GOC:pz]"}
{"concept_id": "C4328242", "aliases": [], "types": ["T044"], "canonical_name": "soyasapogenol B glucuronosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B <=> H+ + UDP + soyasapogenol B 3-O-beta-glucuronate. [EC:2.4.1.262, GOC:pz]"}
{"concept_id": "C4328243", "aliases": [], "types": ["T044"], "canonical_name": "sinapaldehyde:NAD(P)+ oxidoreductase activity", "definition": "Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O <=> 2 H+ + trans-sinapate + NADPH. [EC:1.2.1.-, GOC:pz]"}
{"concept_id": "C4328244", "aliases": [], "types": ["T044"], "canonical_name": "isofucosterol hydroxylase activity", "definition": "Catalysis of the reaction: H+ + isofucosterol + O2 + NADPH <=> (22alpha)-hydroxy-isofucosterol + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328245", "aliases": [], "types": ["T044"], "canonical_name": "sitosterol hydroxylase activity", "definition": "Catalysis of the reaction: H+ + sitosterol + O2 + NADPH <=> (22alpha)-hydroxy-sitosterol + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328246", "aliases": [], "types": ["T044"], "canonical_name": "cannabidiolate synthase activity", "definition": "Catalysis of the reaction: cannabigerolate + O2 <=> cannabidiolate + hydrogen peroxide. [GOC:pz, RHEA:34411]"}
{"concept_id": "C4328247", "aliases": [], "types": ["T044"], "canonical_name": "delta9-tetrahydrocannabinolate synthase activity", "definition": "Catalysis of the reaction: cannabigerolate + O2 <=> delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide. [GOC:pz, RHEA:34135]"}
{"concept_id": "C4328248", "aliases": [], "types": ["T044"], "canonical_name": "caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "definition": "Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA <=> pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-). [EC:2.3.1.153, GOC:pz]"}
{"concept_id": "C4328249", "aliases": [], "types": ["T044"], "canonical_name": "UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328250", "aliases": [], "types": ["T044"], "canonical_name": "p-coumaroyltriacetic acid lactone synthase activity", "definition": "Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + 3 malonyl-CoA( <=> p-coumaroyltriacetic acid lactone + 4 coenzyme A + 3 carbon dioxide. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328251", "aliases": [], "types": ["T044"], "canonical_name": "naringenin 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine <=> sakuranetin + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.232, GOC:pz]"}
{"concept_id": "C4328252", "aliases": [], "types": ["T044"], "canonical_name": "phytyl-P kinase activity", "definition": "Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate <=> (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate. [EC:2.7.4.-, GOC:pz]"}
{"concept_id": "C4328253", "aliases": [], "types": ["T044"], "canonical_name": "eriodictyol 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + hesperetin(1-) + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328254", "aliases": [], "types": ["T044"], "canonical_name": "eriodictyol 3'-O-methyltransferase activity", "definition": "Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + homoeriodictyol + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328255", "aliases": [], "types": ["T044"], "canonical_name": "6-deoxocathasterone hydroxylase activity", "definition": "Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor <=> 6-deoxoteasterone + H2O + an oxidized electron acceptor. [EC:1.14.-.-, GOC:pz]"}
{"concept_id": "C4328256", "aliases": [], "types": ["T044"], "canonical_name": "campestanol hydroxylase activity", "definition": "Catalysis of the reaction: H+ + campestanol + O2 + NADPH <=> 6-deoxycathasterone + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328257", "aliases": [], "types": ["T044"], "canonical_name": "chlorophyllide-b:phytyl-diphosphate phytyltransferase activity", "definition": "Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate <=> chlorophyll b + diphosphoric acid. [EC:2.5.1.-, GOC:pz]"}
{"concept_id": "C4328258", "aliases": [], "types": ["T044"], "canonical_name": "chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity", "definition": "Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate <=> geranylgeranyl-chlorophyll b + diphosphoric acid. [EC:2.5.1.-, GOC:pz]"}
{"concept_id": "C4328259", "aliases": [], "types": ["T044"], "canonical_name": "chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity", "definition": "Catalysis of the reaction: H+ + chlorophyllide a(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) <=> geranylgeranyl-chlorophyll a + diphosphoric acid. [EC:2.5.1.-, GOC:pz]"}
{"concept_id": "C4328260", "aliases": [], "types": ["T044"], "canonical_name": "eriodictyol,NADPH:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 <=> 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328261", "aliases": [], "types": ["T044"], "canonical_name": "R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity", "definition": "Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH <=> (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP. [EC:1.1.1.237, GOC:pz]"}
{"concept_id": "C4328262", "aliases": [], "types": ["T044"], "canonical_name": "paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity", "definition": "Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine. [EC:2.1.1.160, GOC:pz]"}
{"concept_id": "C4328263", "aliases": [], "types": ["T044"], "canonical_name": "theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity", "definition": "Catalysis of the reaction: theobromine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine. [EC:2.1.1.160, GOC:pz]"}
{"concept_id": "C4328264", "aliases": [], "types": ["T044"], "canonical_name": "brassinolide synthase activity", "definition": "Catalysis of the reaction: H+ + castasterone + NADPH + O2 <=> brassinolide + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328265", "aliases": [], "types": ["T044"], "canonical_name": "cathasterone hydroxylase activity", "definition": "Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor <=> teasterone + H2O + an oxidized electron acceptor. [EC:1.14.-.-, GOC:pz]"}
{"concept_id": "C4328266", "aliases": [], "types": ["T044"], "canonical_name": "TRIBOA-glucoside methyltransferase activity", "definition": "Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine <=> (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.241, GOC:pz]"}
{"concept_id": "C4328267", "aliases": [], "types": ["T044"], "canonical_name": "DIBOA-glucoside oxygenase activity", "definition": "Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate <=> TRIBOA-beta-D-glucoside + succinate + carbon dioxide. [EC:1.14.11.59, GOC:pz]"}
{"concept_id": "C4328268", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A28,oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 <=> (2betaOH)-gibberellin28 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328269", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A17,oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 <=> gibberellin A28 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328270", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A12,oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 <=> gibberellin A14 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328271", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A25 hydroxylase activity", "definition": "Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 <=> gibberellin A46 + succinate(2-) + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328272", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A13,oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A13 + 2-oxoglutarate + O2 <=> gibberellin A43 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328273", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A25,oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate + O2 <=> gibberellin A13 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328274", "aliases": [], "types": ["T044"], "canonical_name": "serine decarboxylase activity", "definition": "Catalysis of the reaction: H+ + L-serine <=> ethanolaminium(1+) + carbon dioxide. [GOC:pz, PMID:11461929, RHEA:45824]"}
{"concept_id": "C4328275", "aliases": [], "types": ["T044"], "canonical_name": "GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity", "definition": "Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol <=> H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol. [EC:2.4.1.257, GOC:pz]"}
{"concept_id": "C4328276", "aliases": [], "types": ["T044"], "canonical_name": "camphene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate <=> (-)-camphene + diphosphoric acid. [EC:4.2.3.117, GOC:pz]"}
{"concept_id": "C4328277", "aliases": [], "types": ["T044"], "canonical_name": "2-carene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate <=> (+)-2-carene + diphosphoric acid. [GOC:pz, PMID:10700382]"}
{"concept_id": "C4328278", "aliases": [], "types": ["T044"], "canonical_name": "tricyclene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate(3-) <=> tricyclene + diphosphoric acid. [EC:4.2.3.105, GOC:pz]"}
{"concept_id": "C4328279", "aliases": [], "types": ["T044"], "canonical_name": "alpha-thujene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate(3-) <=> alpha-thujene + diphosphoric acid. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328280", "aliases": [], "types": ["T044"], "canonical_name": "2-methylpropionitrile hydroxylase activity", "definition": "Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH <=> 2-hydroxy-2-methylpropanenitrile + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328281", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin <=> H+ + cis-zeatin-7-N-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328282", "aliases": [], "types": ["T044"], "canonical_name": "kinetin UDP glycosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + 9-(alpha-D-glucosyl)kinetin + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328283", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:kinetin 7-N-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + kinetin-7-N-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328284", "aliases": [], "types": ["T044"], "canonical_name": "benzyladenine UDP glycosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328285", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:benzyladenine 7-N-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + benzyladenine-7-N-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328286", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine <=> H+ + 7-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328287", "aliases": [], "types": ["T044"], "canonical_name": "dihydrozeatin UDP glycosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328288", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + dihydrozeatin-7-N-glucose + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328289", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:trans-zeatin 9-N-glucosyltransferase", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + trans-zeatin <=> H+ + 9-(alpha-D-glucosyl)-trans-zeatin + UDP(3-). [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328290", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + trans-zeatin <=> H+ + trans-zeatin-7-N-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328291", "aliases": [], "types": ["T044"], "canonical_name": "L-phenylalanine N-monooxygenase activity", "definition": "Catalysis of the reaction: L-phenylalanine + 2 NADPH + 2 O2 + 2 H+ <=> (E)-phenylacetaldehyde oxime + 2 NADP + 3 H2O + carbon dioxide. [EC:1.14.14.40, GOC:pz]"}
{"concept_id": "C4328292", "aliases": [], "types": ["T044"], "canonical_name": "N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity", "definition": "Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O <=> N(6)-dimethylallyladenine + D-ribofuranose 5-phosphate. [EC:3.2.2.-, GOC:pz]"}
{"concept_id": "C4328293", "aliases": [], "types": ["T044"], "canonical_name": "isoamylase (maltodextrin-releasing) activity", "definition": "Catalysis of the reaction: n H2O + a glycogen <=> n a maltodextrin. [EC:3.2.1.68, GOC:pz]"}
{"concept_id": "C4328294", "aliases": [], "types": ["T044"], "canonical_name": "campest-4-en-3-one hydroxylase activity", "definition": "Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH <=> (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328295", "aliases": [], "types": ["T044"], "canonical_name": "(5alpha)-campestan-3-one hydroxylase activity", "definition": "Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP. [GOC:pz, PMID:10377996]"}
{"concept_id": "C4328296", "aliases": [], "types": ["T044"], "canonical_name": "22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity", "definition": "Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + NADP <=> H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4328297", "aliases": [], "types": ["T044"], "canonical_name": "campesterol,NADPH:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: H+ + campesterol + O2 + NADPH <=> (22S)-22-hydroxycampesterol + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328298", "aliases": [], "types": ["T044"], "canonical_name": "avenasterol-desaturase activity", "definition": "Catalysis of the reaction: avenasterol + O2 + NADPH + H+ <=> 5-dehydroavenasterol + 2 H2O + NADP. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328301", "aliases": [], "types": ["T044"], "canonical_name": "fatty aldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde <=> NADH(2-) + 2 H+ + a fatty acid. [EC:1.2.1.3, GOC:pz]"}
{"concept_id": "C4328302", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid alpha-oxygenase activity", "definition": "Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid <=> a 2(R)-hydroperoxy fatty acid. [EC:1.13.11.-, GOC:pz]"}
{"concept_id": "C4328303", "aliases": [], "types": ["T044"], "canonical_name": "6a-hydroxymaackiain-3-O-methyltransferase activity", "definition": "Catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> H+ + (+)-pisatin + S-adenosyl-L-homocysteine. [EC:2.1.1.270, GOC:pz]"}
{"concept_id": "C4328304", "aliases": [], "types": ["T044"], "canonical_name": "2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: 2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> H+ + 2,7-dihydroxy-4'-methoxyisoflavanone + S-adenosyl-L-homocysteine. [EC:2.1.1.212, GOC:pz]"}
{"concept_id": "C4328305", "aliases": [], "types": ["T044"], "canonical_name": "isoflavone-7-O-glucoside beta-glucosidase activity", "definition": "Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O <=> daidzein + beta-D-glucose. [EC:3.2.1.-, GOC:pz]"}
{"concept_id": "C4328306", "aliases": [], "types": ["T044"], "canonical_name": "liquiritigenin,NADPH:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: liquiritigenin + NADPH + O2 + H+ <=> 2,4',7-trihydroxyisoflavanone + NADP(3-) + H2O. [EC:1.14.14.87, GOC:pz]"}
{"concept_id": "C4328307", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-beta-1-D-glucose hydrolase activity", "definition": "Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose. [EC:3.1.-.-, GOC:pz]"}
{"concept_id": "C4328308", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-beta-4-D-glucose hydrolase activity", "definition": "Catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose. [EC:3.1.-.-, GOC:pz]"}
{"concept_id": "C4328309", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-glutamate synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + L-glutamate + ATP <=> H+ + indole-3-acetyl-glutamate + AMP + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4328310", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-leucine synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + L-leucine + ATP <=> H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4328311", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A34 + 2-oxoglutarate + O2 <=> H+ + gibberellin A34-catabolite + succinate + carbon dioxide + H2O. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328312", "aliases": [], "types": ["T044"], "canonical_name": "malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity", "definition": "Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) <=> acetyl-CoA(4-) + carbon dioxide + NADH(2-). [EC:1.2.1.-, GOC:pz]"}
{"concept_id": "C4328313", "aliases": [], "types": ["T044"], "canonical_name": "homogentisate solanyltransferase activity", "definition": "Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ <=> 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid. [EC:2.5.1.117, GOC:pz]"}
{"concept_id": "C4328314", "aliases": [], "types": ["T044"], "canonical_name": "caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity", "definition": "Catalysis of the reaction: caffeoylshikimate + coenzyme A <=> caffeoyl-CoA + shikimate. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328315", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate <=> H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP. [EC:2.4.1.195, GOC:pz]"}
{"concept_id": "C4328316", "aliases": [], "types": ["T044"], "canonical_name": "2-oxo-5-methylthiopentanoate aminotransferase activity", "definition": "Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid <=> L-homomethionine + a 2-oxo carboxylate. [EC:2.6.1.-, GOC:pz]"}
{"concept_id": "C4328317", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4328318", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity", "definition": "Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4328319", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity", "definition": "Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, RHEA:46764]"}
{"concept_id": "C4328320", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 <=> H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328321", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 <=> gibberellin A51 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328322", "aliases": [], "types": ["T044"], "canonical_name": "cyclo-acetoacetyl-L-tryptophan synthetase activity", "definition": "Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP <=> cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]. [EC:6.3.2.-, GOC:pz]"}
{"concept_id": "C4328323", "aliases": [], "types": ["T044"], "canonical_name": "acetoacetyl-ACP synthase activity", "definition": "Catalysis of the reaction: acetyl-CoA + malonyl-CoA + H+ + a holo-[acyl-carrier protein] <=> acetoacetyl-ACP + 2 coenzyme A + carbon dioxide. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328324", "aliases": [], "types": ["T044"], "canonical_name": "D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity", "definition": "Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate. [EC:2.2.1.-, GOC:pz]"}
{"concept_id": "C4328325", "aliases": [], "types": ["T044"], "canonical_name": "D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity", "definition": "Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate. [EC:2.2.1.-, GOC:pz]"}
{"concept_id": "C4328326", "aliases": [], "types": ["T044"], "canonical_name": "14betaH-scalarane-17alpha-19-diol synthase activity", "definition": "Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O. [GOC:pz, PMID:24200803]"}
{"concept_id": "C4328327", "aliases": [], "types": ["T044"], "canonical_name": "17(E)-cheilanthenediol synthase activity", "definition": "Catalysis of the reaction: 17(E)-cheilanthenediol <=> all-trans-geranylfarnesol + H2O. [GOC:pz, PMID:24200803]"}
{"concept_id": "C4328328", "aliases": [], "types": ["T044"], "canonical_name": "monocyclic sesterterpenediol synthase activity", "definition": "Catalysis of the reaction: monocyclic sesterterpenediol <=> all-trans-geranylfarnesol + H2O. [EC:4.2.1.-, GOC:pz]"}
{"concept_id": "C4328329", "aliases": [], "types": ["T044"], "canonical_name": "scalarane-17alpha-19-diol synthase activity", "definition": "Catalysis of the reaction: scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O. [EC:4.2.1.-, GOC:pz]"}
{"concept_id": "C4328330", "aliases": [], "types": ["T044"], "canonical_name": "(R)-lactaldehyde dehydrogenase activity", "definition": "Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+. [GOC:pz]"}
{"concept_id": "C4328331", "aliases": [], "types": ["T044"], "canonical_name": "paspalinine synthase activity", "definition": "Catalysis of the reaction: paspalicine + O2 + NADPH + H+ <=> paspalinine + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328332", "aliases": [], "types": ["T044"], "canonical_name": "paspalicine synthase activity", "definition": "Catalysis of the reaction: 13-desoxypaxilline + NADPH + O2 + H+ <=> paspalicine + NADP + 2 H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328333", "aliases": [], "types": ["T044"], "canonical_name": "5-aminolevulinate-CoA ligase activity", "definition": "Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP <=> 5-aminolevulinyl-CoA + AMP + diphosphoric acid. [EC:6.2.1.-, GOC:pz]"}
{"concept_id": "C4328334", "aliases": [], "types": ["T044"], "canonical_name": "3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine gamma-glutamylcyclotransferase activity", "definition": "Catalysis of the reaction: 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine <=> 3-benzyl-3,6 -bis(cysteinylglycine)- 6-(hydroxymethyl)-diketopiperazine + 2 5-oxo-L-prolinate. [EC:2.3.2.-, GOC:pz]"}
{"concept_id": "C4328335", "aliases": [], "types": ["T044"], "canonical_name": "11-deoxycorticosterone reductase activity", "definition": "Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ <=> 4-pregnen-20,21-diol-3-one + NAD. [GOC:pz, HEA:47716]"}
{"concept_id": "C4328336", "aliases": [], "types": ["T044"], "canonical_name": "1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity", "definition": "Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+. [GOC:pz, PMID:15701630]"}
{"concept_id": "C4328337", "aliases": [], "types": ["T044"], "canonical_name": "flaviolin monooxygenase activity", "definition": "Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 <=> mompain + NAD + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328338", "aliases": [], "types": ["T044"], "canonical_name": "(S)-nandinine synthase activity", "definition": "Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. [GOC:pz, PMID:17250743, PMID:21094631, RHEA:50364]"}
{"concept_id": "C4328339", "aliases": [], "types": ["T044"], "canonical_name": "caffeoylglucose 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine <=> 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328340", "aliases": [], "types": ["T044"], "canonical_name": "gossypetin 8-methyl ester 3'-O-methyltransferase activity", "definition": "Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine <=> gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328341", "aliases": [], "types": ["T044"], "canonical_name": "patuletin 3'-O-methyltransferase activity", "definition": "Catalysis of the reaction: patuletin + S-adenosyl-L-methionine <=> quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328342", "aliases": [], "types": ["T044"], "canonical_name": "costunolide 3beta-hydroxylase activity", "definition": "Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> 3beta-hydroxycostunolide + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328343", "aliases": [], "types": ["T044"], "canonical_name": "parthenolide 3beta-hydroxylase activity", "definition": "Catalysis of the reaction: parthenolide + NADPH + O2 + H+ <=> 3beta-hydroxyparthenolide + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328344", "aliases": [], "types": ["T044"], "canonical_name": "parthenolide synthase activity", "definition": "Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> parthenolide + NADP(3-) + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328345", "aliases": [], "types": ["T044"], "canonical_name": "emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity", "definition": "Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ <=> 14,15-epoxyemindole-SB + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328346", "aliases": [], "types": ["T044"], "canonical_name": "oryzalexin C synthase (oryzalexin A dependent) activity", "definition": "Catalysis of the reaction: oryzalexin A + NAD(P) <=> oryzalexin C + H+ + NAD(P)H. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328347", "aliases": [], "types": ["T044"], "canonical_name": "oryzalexin B synthase activity", "definition": "Catalysis of the reaction: oryzalexin D + NAD(P) <=> oryzalexin B + H+ + NAD(P)H. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328348", "aliases": [], "types": ["T044"], "canonical_name": "oryzalexin C synthase (oryzalexin B dependent) activity", "definition": "Catalysis of the reaction: oryzalexin B + NAD(P) <=> oryzalexin C + H+ + NAD(P)H. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328349", "aliases": [], "types": ["T044"], "canonical_name": "oryzalexin A synthase activity", "definition": "Catalysis of the reaction: oryzalexin D + NAD(P) <=> oryzalexin A + H+ + NAD(P)H. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328350", "aliases": [], "types": ["T044"], "canonical_name": "ent-cassadiene-C2-hydroxylase activity", "definition": "Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ <=> 2alpha-hydroxy-ent-cassadiene + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328351", "aliases": [], "types": ["T044"], "canonical_name": "syn-pimaradiene 6beta-hydroxylase activity", "definition": "Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ <=> 6beta-hydroxy-syn-pimaradiene + NADP + H2O. [GOC:pz, PMID:22215681]"}
{"concept_id": "C4328352", "aliases": [], "types": ["T044"], "canonical_name": "(+)-secoisolariciresinol monoglucoside glucosyltransferase activity", "definition": "Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+. [GOC:pz, PMID:24678929]"}
{"concept_id": "C4328353", "aliases": [], "types": ["T044"], "canonical_name": "(+)-secoisolariciresinol glucosyltransferase activity", "definition": "Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+. [GOC:pz, PMID:24678929]"}
{"concept_id": "C4328355", "aliases": [], "types": ["T044"], "canonical_name": "tetracenomycin B3 8-O-methyl transferase activity", "definition": "Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine <=> tetracenomycin E + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328356", "aliases": [], "types": ["T044"], "canonical_name": "3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity", "definition": "Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ <=> 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328357", "aliases": [], "types": ["T044"], "canonical_name": "octat-9-en-7-ol 5-monooxygenase activity", "definition": "Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ <=> cyclooctat-9-en-5,7-diol + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328358", "aliases": [], "types": ["T044"], "canonical_name": "cyclooctat-9-en-5,7-diol C18-monooxygenase activity", "definition": "Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ <=> cyclooctatin + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328359", "aliases": [], "types": ["T044"], "canonical_name": "naringenin,NADPH:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: (S)-naringenin(1-) + O2 + NADPH + H+ <=> 2-hydroxy-2,3-dihydrogenistein-7-olate + NADP + H2O. [EC:1.14.14.87, GOC:pz]"}
{"concept_id": "C4328360", "aliases": [], "types": ["T044"], "canonical_name": "12-demethyl-elloramycin C12a O-methyltransferase activity", "definition": "Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine <=> elloramycin + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328361", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity", "definition": "Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P). [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328362", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity", "definition": "Catalysis of the reaction: beta-amyrin + O2 + H+ + NADPH = 16beta-hydroxy-beta-amyrin + H2O + NADP. [GOC:pz, RHEA:55440]"}
{"concept_id": "C4328363", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity", "definition": "Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P). [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328364", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity", "definition": "Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-beta-amyrin + H2O + NAD(P). [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328365", "aliases": [], "types": ["T044"], "canonical_name": "3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity", "definition": "Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin D + NADP + H2O. [EC:1.14.14.123, GOC:pz]"}
{"concept_id": "C4328366", "aliases": [], "types": ["T044"], "canonical_name": "3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity", "definition": "Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin E + NADP + H2O. [EC:1.14.14.122, GOC:pz]"}
{"concept_id": "C4328367", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity", "definition": "Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 <=> ent-sandaracopimaradien-3beta-ol + NADP + H2O. [EC:1.14.14.70, GOC:pz]"}
{"concept_id": "C4328368", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity", "definition": "Catalysis of the reaction: cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(6-O-(p-hydroxybenzoyl)-glucosyl)-oxybenzoyl)-glucoside) + beta-D-glucose. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328369", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity", "definition": "Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328370", "aliases": [], "types": ["T044"], "canonical_name": "delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity", "definition": "Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> violdelphin + beta-D-glucose. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328371", "aliases": [], "types": ["T044"], "canonical_name": "delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity", "definition": "Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328372", "aliases": [], "types": ["T044"], "canonical_name": "delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity", "definition": "Catalysis of the reaction: delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-glucoside + 4-hydroxybenzoic acid + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328373", "aliases": [], "types": ["T044"], "canonical_name": "aminodeoxyfutalosine synthase activity", "definition": "Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O <=> aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+. [EC:2.5.1.120, GOC:pz]"}
{"concept_id": "C4328374", "aliases": [], "types": ["T044"], "canonical_name": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity", "definition": "Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [glycoprotein]-(L-serine/L-threonine). [EC:3.2.1.169, GOC:pz]"}
{"concept_id": "C4328375", "aliases": [], "types": ["T044"], "canonical_name": "FR-33289 synthase activity", "definition": "Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 <=> FR-33289 + succinate(2-) + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328376", "aliases": [], "types": ["T044"], "canonical_name": "aurachin C epoxide hydrolase/isomerase activity", "definition": "Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P). [EC:3.3.2.-, GOC:pz]"}
{"concept_id": "C4328377", "aliases": [], "types": ["T044"], "canonical_name": "aurachin C monooxygenase activity", "definition": "Catalysis of the reaction: aurachin C + O2 + H+ + NAD(P)H <=> aurachin C epoxide + H2O + NAD(P). [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328378", "aliases": [], "types": ["T044"], "canonical_name": "D-ribose 2,5-bisphosphate 2-phosphohydrolase activity", "definition": "Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate <=> hydrogenphosphate + D-ribofuranose 5-phosphate. [GOC:pz, RHEA:41616]"}
{"concept_id": "C4328379", "aliases": ["phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase"], "types": ["T044"], "canonical_name": "5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity", "definition": "Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> D-ribofuranose 2,5-bisphosphate + H+. [EC:3.1.4.57, GOC:pz]"}
{"concept_id": "C4328380", "aliases": [], "types": ["T044"], "canonical_name": "protopanaxadiol 6-hydroxylase activity", "definition": "Catalysis of the reaction: (20S)-protopanaxadiol + O2 + NADPH(4-) + H+ <=> protopanaxatriol + NADP + H2O. [EC:1.14.14.121, GOC:pz]"}
{"concept_id": "C4328381", "aliases": [], "types": ["T044"], "canonical_name": "dammarenediol 12-hydroxylase activity", "definition": "Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 <=> (20S)-protopanaxadiol + NADP + H2O. [EC:1.14.14.120, GOC:pz]"}
{"concept_id": "C4328382", "aliases": [], "types": ["T044"], "canonical_name": "homogentisate geranylgeranyl transferase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + homogentisate + H+ <=> diphosphoric acid + 2-methyl-6-geranylgeranyl-1,4-benzoquinol + carbon dioxide. [EC:2.5.1.116, GOC:pz]"}
{"concept_id": "C4328383", "aliases": [], "types": ["T044"], "canonical_name": "2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol <=> S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+. [EC:2.1.1.295, GOC:pz]"}
{"concept_id": "C4328384", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity", "definition": "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O <=> sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+. [EC:3.1.1.26, GOC:pz]"}
{"concept_id": "C4328385", "aliases": [], "types": ["T044"], "canonical_name": "glucosylglycerate hydrolase activity", "definition": "Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate <=> alpha-D-glucose + D-glycerate. [EC:3.3.2.-, GOC:pz]"}
{"concept_id": "C4328386", "aliases": [], "types": ["T044"], "canonical_name": "mannosylglycerate hydrolase activity", "definition": "Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate. [EC:3.3.2.-, GOC:pz]"}
{"concept_id": "C4328387", "aliases": [], "types": ["T044"], "canonical_name": "ornaline synthase activity", "definition": "Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ <=> ornaline + NADP + H2O. [EC:1.5.1.-, GOC:pz]"}
{"concept_id": "C4328388", "aliases": [], "types": ["T044"], "canonical_name": "epsilon-rhodomycinone methylesterase activity", "definition": "Catalysis of the reaction: epsilon-rhodomycinone + H2O <=> 15-demethoxy-epsilon-rhodomycinone + methanol + H+. [EC:3.1.1.95, GOC:pz]"}
{"concept_id": "C4328389", "aliases": [], "types": ["T044"], "canonical_name": "aclacinomycin A methylesterase activity", "definition": "Catalysis of the reaction: aclacinomycin A + H2O <=> 15-demethoxy-aclacinomycin A + methanol + H+. [EC:3.1.1.95, GOC:pz]"}
{"concept_id": "C4328390", "aliases": [], "types": ["T044"], "canonical_name": "ecdysone-phosphate phosphatase activity", "definition": "Catalysis of the reaction: ecdysone 22-phosphate + H2O <=> ecdysone + hydrogenphosphate. [EC:3.1.3.-, GOC:pz]"}
{"concept_id": "C4328391", "aliases": [], "types": ["T044"], "canonical_name": "sakuranetin 6-hydroxylase activity", "definition": "Catalysis of the reaction: sakuranetin + O2 + NADPH + H+ <=> carthamidin-7-methyl ether + H2O + NADP. [GOC:pz, PMID:23184958]"}
{"concept_id": "C4328392", "aliases": [], "types": ["T044"], "canonical_name": "ladanein 6-O-methyltransferase activity", "definition": "Catalysis of the reaction: ladanein + S-adenosyl-L-methionine <=> H+ + salvigenin + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328393", "aliases": [], "types": ["T044"], "canonical_name": "apigenin-7,4'-dimethyl ether 6-hydroxylase activity", "definition": "Catalysis of the reaction: apigenin-7,4'-dimethyl ether + O2 + NADPH + H+ <=> ladanein + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328394", "aliases": [], "types": ["T044"], "canonical_name": "genkwanin 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: genkwanin + S-adenosyl-L-methionine <=> H+ + apigenin-7,4'-dimethyl ether + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328395", "aliases": [], "types": ["T044"], "canonical_name": "genkwanin 6-hydroxylase activity", "definition": "Catalysis of the reaction: genkwanin + O2 + NADPH + H+ <=> scutellarein 7-methyl ether + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328396", "aliases": [], "types": ["T044"], "canonical_name": "ecdysteroid-phosphate phosphatase activity", "definition": "Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = hydrogenphosphate + an ecdysteroid. [GOC:pz, PMID:12721294]"}
{"concept_id": "C4328397", "aliases": [], "types": ["T044"], "canonical_name": "aclacinomycin T methylesterase activity", "definition": "Catalysis of the reaction: aclacinomycin T(1+) + H2O <=> 15-demethylaclacinomycin T + methanol + H+. [EC:3.1.1.95, GOC:pz]"}
{"concept_id": "C4328398", "aliases": [], "types": ["T044"], "canonical_name": "apigenin 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate <=> S-adenosyl-L-homocysteine + genkwanin. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328399", "aliases": [], "types": ["T044"], "canonical_name": "7,8,4'-trihydroxyflavone methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone <=> H+ + S-adenosyl-L-homocysteine + 7,4'-dihydroxy, 8-methoxyflavone. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328400", "aliases": [], "types": ["T044"], "canonical_name": "8-demethylnovobiocate synthase activity", "definition": "Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) <=> H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid. [EC:6.3.1.15, GOC:pz]"}
{"concept_id": "C4328401", "aliases": [], "types": ["T044"], "canonical_name": "8-demethylnovobiocic acid C8-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid <=> S-adenosyl-L-homocysteine + novobiocic acid + H+. [EC:2.1.1.284, GOC:pz]"}
{"concept_id": "C4328402", "aliases": [], "types": ["T044"], "canonical_name": "2-chloroacrylate reductase activity", "definition": "Catalysis of the reaction: (S)-2-chloropropanoate + NADP <=> 2-chloroacrylate + NADPH + H+. [EC:1.3.1.103, GOC:pz]"}
{"concept_id": "C4328403", "aliases": [], "types": ["T044"], "canonical_name": "tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe <=> 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe. [EC:2.5.1.114, GOC:pz]"}
{"concept_id": "C4328404", "aliases": [], "types": ["T044"], "canonical_name": "delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "definition": "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+. [EC:2.4.1.300, GOC:pz]"}
{"concept_id": "C4328405", "aliases": [], "types": ["T044"], "canonical_name": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "definition": "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+. [EC:2.4.1.300, GOC:pz]"}
{"concept_id": "C4328406", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+. [EC:2.4.1.300, GOC:pz]"}
{"concept_id": "C4328407", "aliases": [], "types": ["T044"], "canonical_name": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity", "definition": "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + vanillate + H+. [EC:2.4.1.300, GOC:pz]"}
{"concept_id": "C4328408", "aliases": [], "types": ["T044"], "canonical_name": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "definition": "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+. [EC:2.4.1.299, GOC:pz]"}
{"concept_id": "C4328409", "aliases": [], "types": ["T044"], "canonical_name": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity", "definition": "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+. [EC:2.4.1.300, GOC:pz]"}
{"concept_id": "C4328410", "aliases": [], "types": ["T044"], "canonical_name": "pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "definition": "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+. [EC:2.4.1.299, GOC:pz]"}
{"concept_id": "C4328411", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3,5-diglucoside glucosidase activity", "definition": "Catalysis of the reaction: cyanin betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose. [EC:3.2.1.-, GOC:pz]"}
{"concept_id": "C4328412", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3,7-diglucoside glucosidase activity", "definition": "Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose. [EC:3.2.1.-, GOC:pz]"}
{"concept_id": "C4328413", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+. [EC:2.4.1.300, GOC:pz]"}
{"concept_id": "C4328414", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+. [EC:2.4.1.299, GOC:pz]"}
{"concept_id": "C4328415", "aliases": [], "types": ["T044"], "canonical_name": "apigeninidin 5-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: apigeninidin + UDP-alpha-D-glucose <=> apigeninidin 5-O-glucoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328416", "aliases": [], "types": ["T044"], "canonical_name": "luteolinidin 5-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: luteolinidin + UDP-alpha-D-glucose <=> luteolinidin 5-O-glucoside + UDP + 2 H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328417", "aliases": [], "types": ["T044"], "canonical_name": "scyllo-inositol dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: scyllo-inositol + NADP <=> 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+. [EC:1.1.1.371, GOC:pz]"}
{"concept_id": "C4328418", "aliases": [], "types": ["T044"], "canonical_name": "GA5 2,3 epoxidase activity", "definition": "Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A6 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328419", "aliases": [], "types": ["T044"], "canonical_name": "GA5 3beta-hydroxylase activity", "definition": "Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A3 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328420", "aliases": [], "types": ["T044"], "canonical_name": "GA20 2,3-desaturase activity", "definition": "Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor <=> gibberellin A5 + 2 H2O + an oxidized electron acceptor. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328421", "aliases": [], "types": ["T044"], "canonical_name": "wogonin 7-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: wogonin + UDP-alpha-D-glucose <=> wogonin 7-O-beta-D-glucoside + UDP + H+. [GOC:pz, PMID:10872235]"}
{"concept_id": "C4328422", "aliases": [], "types": ["T044"], "canonical_name": "8-oxo-dGTP phosphohydrolase activity", "definition": "Catalysis of the reaction: 8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 hydrogenphosphate + 2 H+. [EC:3.6.1.5, GOC:pz]"}
{"concept_id": "C4328423", "aliases": [], "types": ["T044"], "canonical_name": "3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity", "definition": "Catalysis of the reaction: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H+. [EC:3.7.1.22, GOC:pz]"}
{"concept_id": "C4328424", "aliases": [], "types": ["T044"], "canonical_name": "5-fluorocytosine deaminase activity", "definition": "Catalysis of the reaction: H+ + flucytosine + H2O <=> 5-fluorouracil + ammonium. [EC:3.5.4.1, GOC:pz]"}
{"concept_id": "C4328425", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3-O-beta:-D-galactosyltransferase activity", "definition": "Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose <=> quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+. [EC:2.4.1.234, GOC:pz]"}
{"concept_id": "C4328426", "aliases": [], "types": ["T044"], "canonical_name": "2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity", "definition": "Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone <=> H+ + 6C-hexosyl chrysin + H2O. [EC:4.2.1.-, GOC:pz]"}
{"concept_id": "C4328427", "aliases": [], "types": ["T044"], "canonical_name": "pinocembrin 2-hydroxylase activity", "definition": "Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ <=> 2,5,7-trihydroxyflavanone + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328428", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyeriodictyol 6C-glucoside dehydratase activity", "definition": "Catalysis of the reaction: 6C-beta-D-glucosyl-2-hydroxyeriodictyol <=> isoorientin + H2O. [EC:4.2.1.-, GOC:pz]"}
{"concept_id": "C4328429", "aliases": [], "types": ["T044"], "canonical_name": "eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity", "definition": "Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328430", "aliases": [], "types": ["T044"], "canonical_name": "eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity", "definition": "Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328431", "aliases": [], "types": ["T044"], "canonical_name": "eriodictyol 2-hydroxylase activity", "definition": "Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ <=> 2-hydroxyeriodictyol + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328432", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxynaringenin-6C-glucoside dehydratase activity", "definition": "Catalysis of the reaction: 6C-glucosyl-2-hydroxynaringenin <=> isovitexin-7-olate + H2O. [EC:4.2.1.-, GOC:pz]"}
{"concept_id": "C4328433", "aliases": [], "types": ["T044"], "canonical_name": "6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity", "definition": "Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 6C-glucosyl-2-hydroxynaringenin + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328434", "aliases": [], "types": ["T044"], "canonical_name": "naringenin 2-hydroxylase activity", "definition": "Catalysis of the reaction: (S)-naringenin + NADPH + O2 <=> 2-hydroxynaringenin + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328435", "aliases": [], "types": ["T044"], "canonical_name": "wogonin 7-O-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate + H+. [EC:2.4.1.253, GOC:pz]"}
{"concept_id": "C4328436", "aliases": [], "types": ["T044"], "canonical_name": "scutellarein 7-O-glucuronosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucuronate + scutellarein <=> UDP( + scutellarin + H+. [EC:2.4.1.253, GOC:pz]"}
{"concept_id": "C4328437", "aliases": [], "types": ["T044"], "canonical_name": "zeaxanthin 2,2'-beta-hydroxylase activity", "definition": "Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 <=> nostoxanthin + 2 NAD + 2 H2O. [GOC:pz]"}
{"concept_id": "C4328438", "aliases": [], "types": ["T044"], "canonical_name": "zeaxanthin 2-beta-hydroxylase activity", "definition": "Catalysis of the reaction: zeaxanthin + O2 + NADH + H+ <=> caloxanthin + H2O + NAD. [GOC:pz, PMID:22509387]"}
{"concept_id": "C4328439", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose <=> quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328440", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3-sophoroside 7-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328441", "aliases": [], "types": ["T044"], "canonical_name": "kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328442", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> cyanin betaine + vanillate + H+. [EC:2.4.1.299, GOC:pz]"}
{"concept_id": "C4328443", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate. [EC:2.4.1.300, GOC:pz]"}
{"concept_id": "C4328444", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity", "definition": "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-sinapoyl-beta-D-glucose <=> cyanin betaine + trans-sinapate + H+. [EC:2.4.1.299, GOC:pz]"}
{"concept_id": "C4328445", "aliases": [], "types": ["T044"], "canonical_name": "bisdemethoxycurcumin synthase activity", "definition": "Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ <=> 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide. [EC:2.3.1.211, GOC:pz]"}
{"concept_id": "C4328446", "aliases": [], "types": ["T044"], "canonical_name": "kaempferide 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 3,4'-dimethylkaempferol + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328447", "aliases": [], "types": ["T044"], "canonical_name": "kaempferide 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 7,4'-dimethylkaempferol + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328448", "aliases": [], "types": ["T044"], "canonical_name": "kaempferol 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: kaempferol oxoanion + S-adenosyl-L-methionine <=> 3-O-methylkaempferol + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328449", "aliases": [], "types": ["T044"], "canonical_name": "rhamnetin 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> ombuin + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328450", "aliases": [], "types": ["T044"], "canonical_name": "rhamnetin 3'-O-methyltransferase activity", "definition": "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328451", "aliases": [], "types": ["T044"], "canonical_name": "rhamnetin 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328452", "aliases": [], "types": ["T044"], "canonical_name": "3-methylquercetin 3'-O-methyltransferase activity", "definition": "Catalysis of the reaction: 3',4',5-trihydroxy-3-methoxyflavon-7-olate + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328453", "aliases": [], "types": ["T044"], "canonical_name": "isorhamnetin 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328454", "aliases": [], "types": ["T044"], "canonical_name": "L-2-hydroxycarboxylate dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate <=> NADH(2-) + H+ + a 2-oxo carboxylate. [EC:1.1.1.337, GOC:pz]"}
{"concept_id": "C4328455", "aliases": [], "types": ["T044"], "canonical_name": "syringetin 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 3,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328456", "aliases": [], "types": ["T044"], "canonical_name": "syringetin 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 7,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328457", "aliases": [], "types": ["T044"], "canonical_name": "3',4',5'-trimethylmyricetin 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328458", "aliases": [], "types": ["T044"], "canonical_name": "3',4',5'-trimethylmyricetin 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 7,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328459", "aliases": [], "types": ["T044"], "canonical_name": "laricitrin 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine <=> H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328460", "aliases": [], "types": ["T044"], "canonical_name": "myricetin 3-O-methyltransferase activity"}
{"concept_id": "C4328461", "aliases": [], "types": ["T044"], "canonical_name": "7-methylmyricetin 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine <=> 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328462", "aliases": [], "types": ["T044"], "canonical_name": "myricetin 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine <=> 7-O-methylmyricetin + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328463", "aliases": [], "types": ["T044"], "canonical_name": "phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity", "definition": "Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate <=> L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine. [EC:1.14.16.1, GOC:pz]"}
{"concept_id": "C4328464", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 7-O-methyltransferase activity", "definition": "Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine <=> rhamnetin + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328465", "aliases": [], "types": ["T044"], "canonical_name": "genistein-3-O-glucoside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: genistin + UDP-alpha-D-glucose <=> genistin 7-gentiobioside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328466", "aliases": [], "types": ["T044"], "canonical_name": "kaempferol-3-O-glucoside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose <=> kaempferol-3-gentiobioside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328467", "aliases": [], "types": ["T044"], "canonical_name": "allocryptopine 6-hydroxylase activity", "definition": "Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ <=> 6-hydroxy-allocryptopine + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328468", "aliases": [], "types": ["T044"], "canonical_name": "myricetin-3-O-glucoside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: myricetin 3-O-beta-D-glucopyranoside + UDP-alpha-D-glucose <=> myricetin 3-O-gentiobioside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328469", "aliases": [], "types": ["T044"], "canonical_name": "myricetin 3-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: myricetin + UDP-alpha-D-glucose <=> myricetin 3-O-beta-D-glucopyranoside + UDP. [EC:2.4.1.91, GOC:pz]"}
{"concept_id": "C4328470", "aliases": [], "types": ["T044"], "canonical_name": "sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: (+)-sesaminol 2-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-gentiotrioside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328471", "aliases": [], "types": ["T044"], "canonical_name": "(+)-sesaminol 2-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+. [GOC:pz, PMID:18248594, PMID:19561332]"}
{"concept_id": "C4328472", "aliases": [], "types": ["T044"], "canonical_name": "curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotetraside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328473", "aliases": [], "types": ["T044"], "canonical_name": "curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotrioside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328474", "aliases": [], "types": ["T044"], "canonical_name": "apigenin-7-O-glucoside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: apigenin 7-O-beta-D-glucoside + UDP-alpha-D-glucose <=> apigenin-7-O-gentiobioside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328475", "aliases": [], "types": ["T044"], "canonical_name": "quercetin gentiotrioside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotetraside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328476", "aliases": [], "types": ["T044"], "canonical_name": "quercetin gentiobioside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: quercetin-3-gentiobioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotrioside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328477", "aliases": [], "types": ["T044"], "canonical_name": "quercetin-3-O-glucoside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin-3-gentiobioside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328478", "aliases": [], "types": ["T044"], "canonical_name": "6-O-methyl-deacetylisoipecoside beta-glucosidase activity", "definition": "Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O <=> 6-O-methyl-N-deacetylisoipecoside aglycon + beta-D-glucose. [EC:3.2.1.-, GOC:pz]"}
{"concept_id": "C4328479", "aliases": [], "types": ["T044"], "canonical_name": "valerena-4,7(11)-diene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> valerena-4,7(11)-diene + diphosphoric acid. [EC:4.2.3.139, GOC:pz]"}
{"concept_id": "C4328480", "aliases": [], "types": ["T044"], "canonical_name": "quercetin-3,4'-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-). [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328481", "aliases": [], "types": ["T044"], "canonical_name": "quercetin-4',3-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-). [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328482", "aliases": [], "types": ["T044"], "canonical_name": "sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity", "definition": "Catalysis of the reaction: behenoyl-CoA + sn-glycerol 3-phosphate(2-) <=> coenzyme A + 2-docosanoyl-glycerol 3-phosphate. [EC:2.3.1.198, GOC:pz]"}
{"concept_id": "C4328483", "aliases": [], "types": ["T044"], "canonical_name": "sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity", "definition": "Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate <=> coenzyme A + sn-2-C16:0-DCA-LPA. [EC:2.3.1.198, GOC:pz]"}
{"concept_id": "C4328484", "aliases": [], "types": ["T044"], "canonical_name": "sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity", "definition": "Catalysis of the reaction: C22:0-DCA-CoA + sn-glycerol 3-phosphate <=> coenzyme A + 2-C22:0-DCA-LPA. [EC:2.3.1.198, GOC:pz]"}
{"concept_id": "C4328485", "aliases": [], "types": ["T044"], "canonical_name": "omega-hydroxypalmitate O-sinapoyl transferase activity", "definition": "Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate <=> coenzyme A + 16-sinapoyloxypalmitate. [EC:2.3.1.188, GOC:pz]"}
{"concept_id": "C4328486", "aliases": [], "types": ["T044"], "canonical_name": "(+)-taxifolin 5'-hydroxylase activity", "definition": "Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O. [GOC:pz]"}
{"concept_id": "C4328487", "aliases": [], "types": ["T044"], "canonical_name": "linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "definition": "Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O <=> vicianose + linalool. [EC:3.2.1.149, GOC:pz]"}
{"concept_id": "C4328488", "aliases": [], "types": ["T044"], "canonical_name": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328489", "aliases": [], "types": ["T044"], "canonical_name": "dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328490", "aliases": [], "types": ["T044"], "canonical_name": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328491", "aliases": [], "types": ["T044"], "canonical_name": "9-cis-10'-apo-beta-carotenal cleavage oxygenase activity", "definition": "Catalysis of the reaction: 9-cis-10'-apo-beta-carotenal + 2 O2 <=> carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal. [EC:1.13.11.69, GOC:pz]"}
{"concept_id": "C4328492", "aliases": [], "types": ["T044"], "canonical_name": "9-cis-beta-carotene 9',10'-cleavage oxygenase activity", "definition": "Catalysis of the reaction: 9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone. [EC:1.13.11.68, GOC:pz]"}
{"concept_id": "C4328493", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxy-L-isoleucine dehydrogenase activity", "definition": "Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD <=> (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328494", "aliases": [], "types": ["T044"], "canonical_name": "decanoyl-[acp] 2-dehydrogenase activity", "definition": "Catalysis of the reaction: FAD + H+ + a decanoyl-HmqF protein <=> FADH2(2-) + a 2,3-dehydro-decanoyl-HmqF. [EC:1.3.8.-, GOC:pz]"}
{"concept_id": "C4328495", "aliases": [], "types": ["T044"], "canonical_name": "decanoate-[HmqF protein] ligase activity", "definition": "Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein <=> AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein. [EC:6.2.1.-, GOC:pz]"}
{"concept_id": "C4328496", "aliases": [], "types": ["T044"], "canonical_name": "decanoate-CoA ligase activity", "definition": "Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA. [GOC:pz, RHEA:33627]"}
{"concept_id": "C4328497", "aliases": [], "types": ["T044"], "canonical_name": "mycophenolic acid acyl-glucuronide esterase activity", "definition": "Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O <=> mycophenolate + H+ + D-glucopyranuronate. [EC:3.1.1.93, GOC:pz]"}
{"concept_id": "C4328498", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N,N'-diacetylbacillosamine 2-epimerase activity", "definition": "Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+. [EC:3.2.1.184, GOC:pz]"}
{"concept_id": "C4328499", "aliases": [], "types": ["T044"], "canonical_name": "rebaudioside B glucosyltransferase activity", "definition": "Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328500", "aliases": [], "types": ["T044"], "canonical_name": "lupeol 28-oxidase activity", "definition": "Catalysis of the reaction: lupeol + 3 NADPH + 3 O2 + 3 H+ <=> betulinic acid + 3 NADP + 4 H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328501", "aliases": [], "types": ["T044"], "canonical_name": "11-oxo-beta-amyrin 30-oxidase activity", "definition": "Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ <=> glycyrrhetinic acid + 3 NADP + 4 H2O. [GOC:pz, RHEA:35499]"}
{"concept_id": "C4328502", "aliases": [], "types": ["T044"], "canonical_name": "ursolic aldehyde 28-monooxygenase activity", "definition": "Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ <=> ursolic acid + NADP + H2O. [GOC:pz, PMID:22039103]"}
{"concept_id": "C4328503", "aliases": [], "types": ["T044"], "canonical_name": "uvaol dehydrogenase activity", "definition": "Catalysis of the reaction: uvaol + NADPH + O2 + H+ <=> ursolic aldehyde + NADP + 2 H2O. [GOC:pz, PMID:22039103]"}
{"concept_id": "C4328504", "aliases": [], "types": ["T044"], "canonical_name": "alpha-amyrin 28-monooxygenase activity", "definition": "Catalysis of the reaction: alpha-amyrin + NADPH(4-) + O2 + H+ <=> uvaol + NADP(3-) + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328505", "aliases": [], "types": ["T044"], "canonical_name": "betulin dehydrogenase activity", "definition": "Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 <=> betulinic aldehyde + NADP(3-) + 2 H2O. [EC:1.14.-.-, GOC:pz]"}
{"concept_id": "C4328506", "aliases": [], "types": ["T044"], "canonical_name": "lupeol 28-monooxygenase activity", "definition": "Catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ <=> betulin + NADP(3-) + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328507", "aliases": [], "types": ["T044"], "canonical_name": "11alpha-30-dihydroxy beta-amyrin dehydrogenase activity", "definition": "Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ <=> 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O. [GOC:pz]"}
{"concept_id": "C4328508", "aliases": [], "types": ["T044"], "canonical_name": "beta-amyrin 30-monooxygenase activity", "definition": "Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 <=> 30-hydroxy-beta-amyrin + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328509", "aliases": [], "types": ["T044"], "canonical_name": "2-alpha-hydroxytaxusin 7-beta-hydroxylase activity", "definition": "Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ <=> 2alpha, 7beta-dihydroxytaxusin + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328510", "aliases": [], "types": ["T044"], "canonical_name": "isoscopoletin-O-methyltransferase activity", "definition": "Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine <=> scoparone + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328511", "aliases": [], "types": ["T044"], "canonical_name": "esculetin 3-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 3-O-beta-D-glucosyl-esculetin + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328512", "aliases": [], "types": ["T044"], "canonical_name": "esculetin 4-O-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 4-O-beta-D-glucosyl-esculetin + UDP + H+. [EC:2.4.1.126, GOC:pz]"}
{"concept_id": "C4328513", "aliases": [], "types": ["T044"], "canonical_name": "daphnetin 3-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin <=> UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+. [EC:2.4.1.91, GOC:pz]"}
{"concept_id": "C4328514", "aliases": [], "types": ["T044"], "canonical_name": "daphnetin 4-O-beta-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin <=> UDP + 4-O- beta -D-glucosyl-daphnetin + H+. [EC:2.4.1.126, GOC:pz]"}
{"concept_id": "C4328515", "aliases": [], "types": ["T044"], "canonical_name": "daphnetin-8-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 7,8-dihydroxycoumarin <=> S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxycoumarin + H+. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328516", "aliases": [], "types": ["T044"], "canonical_name": "mithramycin dehydrogenase activity", "definition": "Catalysis of the reaction: mithramycin + NADP <=> mithramycin DK + NADPH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328517", "aliases": [], "types": ["T044"], "canonical_name": "isoitalicene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (+)-isoitalicene. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328518", "aliases": [], "types": ["T044"], "canonical_name": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity", "definition": "Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H+. [EC:3.1.1.91, GOC:pz]"}
{"concept_id": "C4328520", "aliases": [], "types": ["T044"], "canonical_name": "trans-cerot-2-enoyl-CoA reductase activity", "definition": "Catalysis of the reaction: hexacosanoyl-CoA(4-) + NADP(3-) <=> trans-2-hexacosenoyl-CoA + NADPH + H+. [EC:1.3.1.93, GOC:pz]"}
{"concept_id": "C4328521", "aliases": [], "types": ["T044"], "canonical_name": "trans-lignocero-2-enoyl-CoA reductase activity", "definition": "Catalysis of the reaction: tetracosanoyl-CoA + NADP <=> trans-2-tetracosenoyl-CoA + NADPH + H+. [EC:1.3.1.93, GOC:pz]"}
{"concept_id": "C4328522", "aliases": [], "types": ["T044"], "canonical_name": "trans-docosan-2-enoyl-CoA reductase activity", "definition": "Catalysis of the reaction: behenoyl-CoA + NADP <=> trans-2-docosenoyl-CoA + NADPH + H+. [EC:1.3.1.93, GOC:pz]"}
{"concept_id": "C4328523", "aliases": [], "types": ["T044"], "canonical_name": "trans-arachidon-2-enoyl-CoA reductase activity", "definition": "Catalysis of the reaction: icosanoyl-CoA(4-) + NADP(3-) <=> trans-2-icosenoyl-CoA(4-) + NADPH(4-) + H+. [EC:1.3.1.93, GOC:pz]"}
{"concept_id": "C4328524", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-cerotoyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA(4-) <=> trans-2-hexacosenoyl-CoA(4-) + H2O. [EC:4.2.1.134, GOC:pz]"}
{"concept_id": "C4328525", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-lignoceroyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA(4-) <=> trans-2-tetracosenoyl-CoA + H2O. [EC:4.2.1.134, GOC:pz]"}
{"concept_id": "C4328526", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-behenoyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA <=> trans-2-docosenoyl-CoA + H2O. [EC:4.2.1.134, GOC:pz]"}
{"concept_id": "C4328527", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxy-arachidoyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA <=> trans-2-icosenoyl-CoA + H2O. [EC:4.2.1.134, GOC:pz]"}
{"concept_id": "C4328528", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-cerotoyl-CoA reductase activity", "definition": "Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA + NADP <=> 3-oxohexacosanoyl-CoA + NADPH + H+. [EC:1.1.1.330, GOC:pz]"}
{"concept_id": "C4328529", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-lignoceroyl-CoA reductase activity", "definition": "Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA + NADP <=> 3-oxotetracosanoyl-CoA + NADPH + H+. [EC:1.1.1.330, GOC:pz]"}
{"concept_id": "C4328530", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-behenoyl-CoA reductase activity", "definition": "Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA(4-) + NADP(3-) <=> 3-oxodocosanoyl-CoA + NADPH + H+. [EC:1.1.1.330, GOC:pz]"}
{"concept_id": "C4328531", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-arachidoyl-CoA reductase activity", "definition": "Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA(4-) + NADP(3-) <=> 3-oxoicosanoyl-CoA + NADPH + H+. [EC:1.1.1.330, GOC:pz]"}
{"concept_id": "C4328532", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-lignoceronyl-CoA synthase activity", "definition": "Catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxotetracosanoyl-CoA. + carbon dioxide + coenzyme A. [GOC:pz, RHEA:36507]"}
{"concept_id": "C4328533", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-cerotoyl-CoA synthase activity", "definition": "Catalysis of the reaction: tetracosanoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxohexacosanoyl-CoA + carbon dioxide + coenzyme A. [GOC:pz, RHEA:36515]"}
{"concept_id": "C4328534", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-arachidoyl-CoA synthase activity", "definition": "Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A. [GOC:pz, RHEA:35319]"}
{"concept_id": "C4328535", "aliases": [], "types": ["T044"], "canonical_name": "N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity", "definition": "Catalysis of the reaction: N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-D-galactosamine <=> N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP + H+. [EC:2.4.1.290, GOC:pz]"}
{"concept_id": "C4328536", "aliases": [], "types": ["T044"], "canonical_name": "N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity", "definition": "Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP. [EC:2.7.8.36, GOC:pz]"}
{"concept_id": "C4328537", "aliases": [], "types": ["T044"], "canonical_name": "hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA reductase activity", "definition": "Catalysis of the reaction: 16-hydroxy-hentriaconta-3,6,9,12,19,22,25,28-octaene-15-oyl-CoA + NADP <=> hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA + NADPH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328538", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O <=> 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+. [EC:3.7.1.8, GOC:pz]"}
{"concept_id": "C4328539", "aliases": [], "types": ["T044"], "canonical_name": "2,2',3-trihydroxybiphenyl monooxygenase activity", "definition": "Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O. [GOC:pz, RHEA:63516]"}
{"concept_id": "C4328540", "aliases": [], "types": ["T044"], "canonical_name": "2,2'-hydroxybiphenyl monooxygenase activity", "definition": "Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD. [GOC:pz, RHEA:63512]"}
{"concept_id": "C4328541", "aliases": [], "types": ["T044"], "canonical_name": "1,8-cineole 2-exo-monooxygenase activity", "definition": "Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 <=> 2-exo-hydroxy-1,8-cineole + NADP + H2O. [GOC:pz, RHEA:32895]"}
{"concept_id": "C4328542", "aliases": [], "types": ["T044"], "canonical_name": "2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity", "definition": "Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine <=> H+ + 2'-N-acetylparomamine(2+) + UDP(3-). [EC:2.4.1.283, GOC:pz]"}
{"concept_id": "C4328543", "aliases": [], "types": ["T044"], "canonical_name": "2-deoxystreptamine glucosyltransferase activity", "definition": "Catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+. [EC:2.4.1.284, GOC:pz]"}
{"concept_id": "C4328544", "aliases": [], "types": ["T044"], "canonical_name": "4-methylaminobutyrate oxidase (demethylating) activity", "definition": "Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O <=> gamma-aminobutyric acid + formaldehyde + hydrogen peroxide. [EC:1.5.3.19, GOC:pz]"}
{"concept_id": "C4328546", "aliases": [], "types": ["T044"], "canonical_name": "8-hydroxygeraniol dehydrogenase activity", "definition": "Catalysis of the reaction: (6E)-8-hydroxygeraniol + 2 NADP <=> (6E)-8-oxogeranial + 2 NADPH + 2 H+. [EC:1.1.1.324, GOC:pz]"}
{"concept_id": "C4328547", "aliases": [], "types": ["T044"], "canonical_name": "dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity", "definition": "Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) <=> dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H. [EC:1.17.1.-, GOC:pz]"}
{"concept_id": "C4328548", "aliases": [], "types": ["T044"], "canonical_name": "dTDP-4-oxo-2,6-dideoxy-D-glucose 4-ketoreductase (dTDP-D-oliose producing) activity", "definition": "Catalysis of the reaction: dTDP-D-oliose + NADP <=> dTDP-4-dehydro-2,6-dideoxy-D-glucose + NADPH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328549", "aliases": [], "types": ["T044"], "canonical_name": "erythromycin D 3''-o-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D <=> S-adenosyl-L-homocysteine + erythromycin B + H+. [EC:2.1.1.254, GOC:pz]"}
{"concept_id": "C4328550", "aliases": [], "types": ["T044"], "canonical_name": "erythromycin C 3''-o-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin C <=> S-adenosyl-L-homocysteine + erythromycin A + H+. [EC:2.1.1.254, GOC:pz]"}
{"concept_id": "C4328551", "aliases": [], "types": ["T044"], "canonical_name": "benzil reductase [(S)-benzoin-forming] activity", "definition": "Catalysis of the reaction: (S)-benzoin + NADP(3-) <=> benzil + NADPH(4-) + H+. [EC:1.1.1.320, GOC:pz]"}
{"concept_id": "C4328552", "aliases": [], "types": ["T044"], "canonical_name": "(13E)-labda-7,13-dien-15-ol synthase activity", "definition": "Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphoric acid. [GOC:pz, RHEA:32075]"}
{"concept_id": "C4328553", "aliases": [], "types": ["T044"], "canonical_name": "sesquithujene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> 7-epi-sesquithujene + diphosphoric acid. [EC:4.2.3.102, GOC:pz]"}
{"concept_id": "C4328554", "aliases": [], "types": ["T044"], "canonical_name": "resveratrol 3,5-O-dimethyltransferase activity", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+. [EC:2.1.1.240, GOC:pz]"}
{"concept_id": "C4328555", "aliases": [], "types": ["T044"], "canonical_name": "mycinamicin VI 2''-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI <=> S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+. [EC:2.1.1.238, GOC:pz]"}
{"concept_id": "C4328556", "aliases": [], "types": ["T044"], "canonical_name": "selenate adenylyltransferase activity", "definition": "Catalysis of the reaction: selenic acid + ATP + 2 H+ <=> adenylyl selenate + diphosphoric acid. [EC:2.7.7.4, GOC:pz]"}
{"concept_id": "C4328557", "aliases": [], "types": ["T044"], "canonical_name": "4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity", "definition": "Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+. [EC:3.7.1.17, GOC:pz]"}
{"concept_id": "C4328558", "aliases": [], "types": ["T044"], "canonical_name": "4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity", "definition": "Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA <=> 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328559", "aliases": [], "types": ["T044"], "canonical_name": "pheophytinase b activity", "definition": "Catalysis of the reaction: pheophytin b + H2O <=> H+ + pheophorbide b + phytol. [EC:3.1.1.14, GOC:pz]"}
{"concept_id": "C4328560", "aliases": [], "types": ["T044"], "canonical_name": "30-hydroxy-beta-amyrin 11-hydroxylase activity", "definition": "Catalysis of the reaction: 30-hydroxy-beta-amyrin + O2 + NADPH + H+ <=> 11alpha,30-dihydroxy-beta-amyrin + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328561", "aliases": [], "types": ["T044"], "canonical_name": "beta-amyrin monooxygenase activity", "definition": "Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ <=> 11alpha-hydroxy-beta-amyrin + H2O + NADP. [EC:1.14.14.152, GOC:pz]"}
{"concept_id": "C4328562", "aliases": [], "types": ["T044"], "canonical_name": "beta-amyrin 11-oxidase activity", "definition": "Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ <=> 11-oxo-beta-amyrin + 3 H2O + 2 NADP. [EC:1.14.14.152, GOC:pz]"}
{"concept_id": "C4328563", "aliases": [], "types": ["T044"], "canonical_name": "4-coumaroylhexanoylmethane synthase activity", "definition": "Catalysis of the reaction: 4-coumaryl-CoA + 3-oxooctanoyl-CoA + H2O <=> 4-coumaroylhexanoylmethane + 2 coenzyme A + carbon dioxide. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328564", "aliases": [], "types": ["T044"], "canonical_name": "L-threo-sphinganine reductase activity", "definition": "Catalysis of the reaction: L-threo-sphinganine + NADP <=> H+ + NADPH + 3-dehydrosphinganinium(1+). [EC:1.1.1.102, GOC:pz]"}
{"concept_id": "C4328565", "aliases": [], "types": ["T044"], "canonical_name": "3-ketodihydrosphinganine (C20) reductase activity", "definition": "Catalysis of the reaction: C20 sphinganine(1+) + NADP <=> C20 3-dehydrosphinganine(1+) + NADPH + H+. [EC:1.1.1.102, GOC:pz]"}
{"concept_id": "C4328566", "aliases": [], "types": ["T044"], "canonical_name": "3-ketodihydrosphinganine (C18) reductase activity", "definition": "Catalysis of the reaction: NAD(1-) + a sphinganine <=> 3-dehydrosphinganinium(1+) + NADH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328567", "aliases": [], "types": ["T044"], "canonical_name": "formylaminopyrimidine deformylase activity", "definition": "Catalysis of the reaction: formylaminopyrimidine + H2O <=> 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate. [EC:3.5.1.-, GOC:pz]"}
{"concept_id": "C4328568", "aliases": [], "types": ["T044"], "canonical_name": "N,N'-diacetylchitobiose synthase activity", "definition": "Catalysis of the reaction: n H2O + chitin <=> N,N'-diacetylchitobiose. [EC:3.2.1.-, GOC:pz]"}
{"concept_id": "C4328569", "aliases": [], "types": ["T044"], "canonical_name": "2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity", "definition": "Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ <=> ethene + 3 carbon dioxide + H2O. [EC:1.13.12.19, GOC:pz]"}
{"concept_id": "C4328570", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-S-conjugate N-malonyl transferase activity", "definition": "Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate <=> coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328571", "aliases": [], "types": ["T044"], "canonical_name": "glutathione S-conjugate carboxypeptidase activity", "definition": "Catalysis of the reaction: H2O + a glutathione-toxin conjugate <=> glycine + a [Glu-Cys]-S-conjugate. [EC:3.4.17.-, GOC:pz]"}
{"concept_id": "C4328572", "aliases": [], "types": ["T044"], "canonical_name": "homophytochelatin synthase (dimmer forming) activity", "definition": "Catalysis of the reaction: glutathionate + L-gamma-glutamyl-L-cysteinyl-beta-alaninate <=> gamma-Glu-Cys-gamma-Glu-Cys-beta-Ala + glycine. [EC:2.3.2.-, GOC:pz]"}
{"concept_id": "C4328573", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-dihydrouridine20b synthase activity", "definition": "Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) <=> H+ + a uracil20b in tRNA + NAD(P)H. [EC:1.3.1.90, GOC:pz]"}
{"concept_id": "C4328574", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-dihydrouridine20a synthase activity", "definition": "Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) <=> H+ + a uracil20a in tRNA + NAD(P)H. [EC:1.3.1.90, GOC:pz]"}
{"concept_id": "C4328575", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-dihydrouridine47 synthase activity", "definition": "Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) <=> H+ + a uracil47 in tRNA + NAD(P)H. [EC:1.3.1.89, GOC:pz]"}
{"concept_id": "C4328576", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-dihydrouridine20 synthase activity", "definition": "Catalysis of the reaction: a 5,6-dihydrouracil20 in tRNA + NAD(P) <=> H+ + a uracil20 in tRNA + NAD(P)H. [EC:1.3.1.91, GOC:pz]"}
{"concept_id": "C4328577", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-dihydrouridine17 synthase activity", "definition": "Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) <=> H+ + a uracil17 in tRNA + NAD(P)H. [EC:1.3.1.88, GOC:pz]"}
{"concept_id": "C4328578", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-dihydrouridine16 synthase activity", "definition": "Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) <=> H+ + a uracil16 in tRNA + NAD(P)H. [EC:1.3.1.88, GOC:pz]"}
{"concept_id": "C4328579", "aliases": [], "types": ["T044"], "canonical_name": "8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity", "definition": "Catalysis of the reaction: NADP + a reduced coenzyme F420 <=> NADPH + H+ + an oxidized coenzyme F420. [EC:1.5.1.40, GOC:pz]"}
{"concept_id": "C4328580", "aliases": [], "types": ["T044"], "canonical_name": "1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity", "definition": "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O <=> 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+. [EC:3.1.1.32, GOC:pz]"}
{"concept_id": "C4328581", "aliases": [], "types": ["T044"], "canonical_name": "neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "definition": "Catalysis of the reaction: neoagarohexaose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agaropentaose. [EC:3.2.1.159, GOC:pz]"}
{"concept_id": "C4328582", "aliases": [], "types": ["T044"], "canonical_name": "neo-lambda-carrahexaose hydrolase activity", "definition": "Catalysis of the reaction: neo-lambda-carrahexaose + H2O <=> neo-lambda-carratetraose + neo-lambda-carrabiose. [EC:3.2.1.162, GOC:pz]"}
{"concept_id": "C4328583", "aliases": [], "types": ["T044"], "canonical_name": "neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "definition": "Catalysis of the reaction: neoagarotetraose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agarotriose. [EC:3.2.1.159, GOC:pz]"}
{"concept_id": "C4328584", "aliases": [], "types": ["T044"], "canonical_name": "neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "definition": "Catalysis of the reaction: neoagarobiose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside. [EC:3.2.1.159, GOC:pz]"}
{"concept_id": "C4328585", "aliases": [], "types": ["T044"], "canonical_name": "malonyl-malonyl acyl carrier protein-condensing enzyme activity", "definition": "Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] <=> 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328586", "aliases": [], "types": ["T044"], "canonical_name": "6-amino-6-deoxyfutalosine hydrolase activity", "definition": "Catalysis of the reaction: aminodeoxyfutalosinate + H2O <=> dehypoxanthine futalosine + adenine. [EC:3.2.2.30, GOC:pz]"}
{"concept_id": "C4328587", "aliases": [], "types": ["T044"], "canonical_name": "lupan-3beta,20-diol synthase activity", "definition": "Catalysis of the reaction: lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O. [EC:4.2.1.128, GOC:pz]"}
{"concept_id": "C4328588", "aliases": [], "types": ["T044"], "canonical_name": "3-aminopropanal dehydrogenase activity", "definition": "Catalysis of the reaction: 3-ammoniopropanal + NAD + H2O <=> 2 H+ + beta-alanine + NADH. [EC:1.2.1.-, GOC:pz]"}
{"concept_id": "C4328589", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent farnesol kinase activity"}
{"concept_id": "C4328590", "aliases": [], "types": ["T044"], "canonical_name": "trans-4-hexen-3-one reductase activity", "definition": "Catalysis of the reaction: trans-4-hexen-3-one + NADPH + H+ <=> hexan-3-one + NADP. [GOC:pz, PMID:21169366]"}
{"concept_id": "C4328591", "aliases": [], "types": ["T044"], "canonical_name": "1-penten-3-one reductase activity", "definition": "Catalysis of the reaction: 1-penten-3-one + NADPH + H+ <=> 1-pentan-3-one + NADP. [GOC:pz]"}
{"concept_id": "C4328592", "aliases": [], "types": ["T044"], "canonical_name": "but-1-en-3-one reductase activity", "definition": "Catalysis of the reaction: buten-2-one + NADPH + H+ <=> butan-2-one + NADP. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4328593", "aliases": [], "types": ["T044"], "canonical_name": "crotonaldehyde redutase activity", "definition": "Catalysis of the reaction: (cis)-crotonaldehyde + NADPH + H+ <=> butanal + NADP. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4328594", "aliases": [], "types": ["T044"], "canonical_name": "acrolein reductase activity", "definition": "Catalysis of the reaction: acrolein + NADPH + H+ <=> propanal + NADP. [GOC:pz, PMID:21169366]"}
{"concept_id": "C4328595", "aliases": [], "types": ["T044"], "canonical_name": "amylopectin maltohydrolase activity", "definition": "Catalysis of the reaction: n H2O + an exposed unphosphorylated, unbranched malto-oligosaccharide tail on amylopectin <=> amylopectin + maltose. [EC:3.2.1.2, GOC:pz]"}
{"concept_id": "C4328596", "aliases": [], "types": ["T044"], "canonical_name": "4,4'-diaponeurosporene desaturase activity", "definition": "Catalysis of the reaction: 4,4'-diaponeurosporene + FAD + H+ <=> 4,4'-diapolycopene + FADH2. [EC:1.3.8.-, GOC:pz]"}
{"concept_id": "C4328597", "aliases": [], "types": ["T044"], "canonical_name": "GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity", "definition": "Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+. [EC:3.2.1.-, GOC:pz]"}
{"concept_id": "C4328598", "aliases": [], "types": ["T044"], "canonical_name": "4,4'-diapophytoene desaturase activity", "definition": "Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD <=> 4,4'-diapolycopene + 4 FADH2. [EC:1.3.8.2, GOC:pz]"}
{"concept_id": "C4328600", "aliases": [], "types": ["T044"], "canonical_name": "thiocyanate methyltransferase activity", "definition": "Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine <=> methyl thiocyanate + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328601", "aliases": [], "types": ["T044"], "canonical_name": "2-polyprenyl-6-hydroxyphenol methylase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol <=> S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol. [EC:2.1.1.222, GOC:pz]"}
{"concept_id": "C4328602", "aliases": [], "types": ["T044"], "canonical_name": "brassicasterol glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol <=> UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+. [EC:2.4.1.173, GOC:pz, RHEA:61840]"}
{"concept_id": "C4328603", "aliases": [], "types": ["T044"], "canonical_name": "soladodine glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + solasodine <=> UDP + solasodine 3-O-beta-D-glucopyranoside + H+. [EC:2.4.1.173, GOC:pz, RHEA:61844]"}
{"concept_id": "C4328604", "aliases": [], "types": ["T044"], "canonical_name": "(+)-2-epi-prezizaene synthase activity", "definition": "Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid. [GOC:pz, PMID:20175559, PMID:20201526]"}
{"concept_id": "C4328605", "aliases": [], "types": ["T044"], "canonical_name": "vinylacetate caboxylester hydrolase activity", "definition": "Catalysis of the reaction: but-3-enoate + H2O <=> allyl alcohol + formate. [GOC:pz, PMID:19555778]"}
{"concept_id": "C4328606", "aliases": [], "types": ["T044"], "canonical_name": "cortisol dehydrogenase activity", "definition": "Catalysis of the reaction: cortisol + NADP <=> cortisone + NADPH + H+. [GOC:pz, PMID:16216911, RHEA:68616]"}
{"concept_id": "C4328607", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity", "definition": "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP <=> UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+. [EC:6.3.2.37, GOC:pz]"}
{"concept_id": "C4328608", "aliases": [], "types": ["T044"], "canonical_name": "protein-fructosamine 3-kinase activity", "definition": "Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine <=> ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine. [EC:2.7.1.171, GOC:pz, PMID:11016445]"}
{"concept_id": "C4328609", "aliases": [], "types": ["T044"], "canonical_name": "protein-ribulosamine 3-kinase activity", "definition": "Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine <=> ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine. [EC:2.7.1.172, GOC:pz]"}
{"concept_id": "C4328611", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "definition": "Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) <=> 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide. [GOC:pz, RHEA:59016]"}
{"concept_id": "C4328612", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) <=> 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328613", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + 2 H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328614", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328615", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol dehydrogenase/C4-decarboxylase activity", "definition": "Catalysis of the reaction: 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) <=> 4alpha,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3-one + NADH(2-) + carbon dioxide. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328616", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 <=> 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328617", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + 2 H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328618", "aliases": [], "types": ["T044"], "canonical_name": "cycloartenol 4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: cycloartenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328619", "aliases": [], "types": ["T044"], "canonical_name": "avenastenone reductase activity", "definition": "Catalysis of the reaction: avenastenone + NADPH + H+ <=> avenasterol + NADP. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328620", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "definition": "Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD <=> avenastenone + NADH + carbon dioxide. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4328621", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328622", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328623", "aliases": [], "types": ["T044"], "canonical_name": "24-ethylidenelophenol 4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328624", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH <=> 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328625", "aliases": [], "types": ["T044"], "canonical_name": "24-methylenelophenol methyl oxidase activity", "definition": "Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O. [GOC:pz, PMID:11707264, RHEA:58872]"}
{"concept_id": "C4328626", "aliases": [], "types": ["T044"], "canonical_name": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity", "definition": "Catalysis of the reaction: a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH. [GOC:pz, RHEA:34775]"}
{"concept_id": "C4328627", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328628", "aliases": [], "types": ["T044"], "canonical_name": "24-methylenecycloartanol 4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328629", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "definition": "Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328630", "aliases": [], "types": ["T044"], "canonical_name": "5-epi-aristolochene-1,3-dihydroxylase activity", "definition": "Catalysis of the reaction: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 O2 <=> capsidiol + 2 NADP + 2 H2O. [EC:1.14.14.149, GOC:pz]"}
{"concept_id": "C4328631", "aliases": [], "types": ["T044"], "canonical_name": "5-methyl-phenazine-1-carboxylate N-methyltransferase activity", "definition": "Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4328632", "aliases": [], "types": ["T044"], "canonical_name": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity", "definition": "Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine. [EC:3.2.1.169, GOC:pz]"}
{"concept_id": "C4328633", "aliases": [], "types": ["T044"], "canonical_name": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity", "definition": "Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-threonine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-threonine. [EC:3.2.1.169, GOC:pz]"}
{"concept_id": "C4328634", "aliases": [], "types": ["T044"], "canonical_name": "(Z)-3-hexen-1-ol acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol <=> (3Z)-hex-3-en-1-yl acetate + coenzyme A. [GOC:pz, RHEA:28254]"}
{"concept_id": "C4328635", "aliases": [], "types": ["T044"], "canonical_name": "2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity", "definition": "Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ <=> 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O. [EC:1.14.13.182, GOC:pz]"}
{"concept_id": "C4328636", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity", "definition": "Catalysis of the reaction: 8'-apo-beta,psi-caroten-8'-al + O2 <=> all-trans-retinal + 2,6-dimethylocta-2,4,6-trienedial. [EC:1.13.11.75, GOC:pz]"}
{"concept_id": "C4328637", "aliases": [], "types": ["T044"], "canonical_name": "(R)-sulfopropanediol 2-dehydrogenase activity", "definition": "Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+. [GOC:pz, PMID:20150239]"}
{"concept_id": "C4328638", "aliases": [], "types": ["T044"], "canonical_name": "2,5-DHBA UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: 2,5-dihydroxybenzoate + UDP-alpha-D-glucose <=> 2,5-dihydroxybenzoate 5-O-beta-D-glucoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328639", "aliases": [], "types": ["T044"], "canonical_name": "S-sulfolactate dehydrogenase activity", "definition": "Catalysis of the reaction: (S)-3-sulfonatolactate + NAD <=> 3-sulfonatopyruvate(2-) + NADH + H+. [EC:1.1.1.310, GOC:pz]"}
{"concept_id": "C4328640", "aliases": [], "types": ["T044"], "canonical_name": "8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity", "definition": "Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 8C-glucosyl-2-hydroxynaringenin + UDP + 2 H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4328641", "aliases": [], "types": ["T044"], "canonical_name": "Delta12-linoleate epoxygenase activity", "definition": "Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 <=> 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328642", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-myristate decarboxylase activity", "definition": "Catalysis of the reaction: 3-oxo-myristate + H+ <=> 2-tridecanone + carbon dioxide. [EC:4.1.1.56, GOC:pz]"}
{"concept_id": "C4328643", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-myristoyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: 3-oxotetradecanoyl-CoA + H2O <=> 3-oxo-myristate + coenzyme A + H+. [EC:3.1.2.-, GOC:pz]"}
{"concept_id": "C4328644", "aliases": [], "types": ["T044"], "canonical_name": "farnesylcysteine lyase activity", "definition": "Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O <=> (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide. [EC:1.8.3.6, GOC:pz]"}
{"concept_id": "C4328645", "aliases": [], "types": ["T044"], "canonical_name": "(3R)-(E)-nerolidol synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphoric acid. [GOC:pz, RHEA:27534]"}
{"concept_id": "C4328646", "aliases": [], "types": ["T044"], "canonical_name": "carboxyspermidine dehydrogenase II activity", "definition": "Catalysis of the reaction: carboxyspermidine + H2O + NADP <=> L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+. [EC:1.5.1.43, GOC:pz]"}
{"concept_id": "C4328647", "aliases": [], "types": ["T044"], "canonical_name": "carboxynorspermidine dehydrogenase I activity", "definition": "Catalysis of the reaction: carboxynorspermidine + NADP + H2O <=> L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+. [EC:1.5.1.43, GOC:pz]"}
{"concept_id": "C4328648", "aliases": [], "types": ["T044"], "canonical_name": "[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate <=> adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate. [EC:2.8.2.-, GOC:pz]"}
{"concept_id": "C4328649", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity", "definition": "Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + (2E)-2-hydroxypenta-2,4-dienoate. [EC:3.7.1.13, GOC:pz]"}
{"concept_id": "C4328650", "aliases": [], "types": ["T044"], "canonical_name": "7-oxateasterone synthase activity", "definition": "Catalysis of the reaction: H+ + teasterone + NADPH + O2 <=> 7-oxateasterone + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328651", "aliases": [], "types": ["T044"], "canonical_name": "3-epi-6-deoxocathasterone C-23 hydroxylase activity", "definition": "Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + reduced (NADPH-hemoprotein reducdtase) + O2 = 6=deoxotyphasterol + oxidized (NADPH-hemoprotein reductase) + H2O. [GOC:pz, PMID:17138693, RHEA:27321]"}
{"concept_id": "C4328652", "aliases": [], "types": ["T044"], "canonical_name": "(22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity", "definition": "Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O. [GOC:pz]"}
{"concept_id": "C4328653", "aliases": [], "types": ["T044"], "canonical_name": "(22S)-22-hydroxy-campesterol C-23 hydroxylase activity", "definition": "Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O. [GOC:pz]"}
{"concept_id": "C4328656", "aliases": [], "types": ["T044"], "canonical_name": "8-oxoguanine deaminase activity", "definition": "Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O <=> 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium. [EC:3.5.4.32, GOC:pz]"}
{"concept_id": "C4328657", "aliases": [], "types": ["T044"], "canonical_name": "coniferyl aldehyde 5-hydroxylase activity", "definition": "Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 <=> 5-hydroxy-coniferaldehyde + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328658", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A9 16alpha,17 epoxidase activity", "definition": "Catalysis of the reaction: gibberellin A9 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A9 + H2O + NAD(P). [EC:1.14.-.-, GOC:pz]"}
{"concept_id": "C4328659", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A12 16alpha,17 epoxidase activity", "definition": "Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P). [EC:1.14.-.-, GOC:pz]"}
{"concept_id": "C4328660", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A4 16alpha,17 epoxidase activity", "definition": "Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H <=> 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P). [EC:1.14.-.-, GOC:pz]"}
{"concept_id": "C4328661", "aliases": [], "types": ["T044"], "canonical_name": "laurate hydroxylase activity", "definition": "Catalysis of the reaction: dodecanoate + NADPH + O2 + H+ <=> 11-hydroxylaurate + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328662", "aliases": [], "types": ["T044"], "canonical_name": "caprate dehydroxylase activity", "definition": "Catalysis of the reaction: decanoate + NADPH + O2 + H+ <=> 10-hydroxycaprate + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4328663", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: gibberellin A20 + 2-oxoglutarate + O2 <=> gibberellin A29 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4328664", "aliases": [], "types": ["T044"], "canonical_name": "tricaffeoyl spermidine O-methyltransferase activity", "definition": "Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine <=> 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine. [GOC:pz, PMID:19077165]"}
{"concept_id": "C4328665", "aliases": [], "types": ["T044"], "canonical_name": "curcumin synthase activity", "definition": "Catalysis of the reaction: feruloylacetyl-CoA + feruloyl-CoA(4-) + H2O <=> curcumin + 2 coenzyme A(4-) + carbon dioxide. [EC:2.3.1.217, GOC:pz]"}
{"concept_id": "C4328666", "aliases": [], "types": ["T044"], "canonical_name": "demethoxycurcumin synthase activity", "definition": "Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O <=> demethoxycurcumin + 2 coenzyme A + carbon dioxide. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328667", "aliases": [], "types": ["T044"], "canonical_name": "demethoxycurcumin synthase", "definition": "Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + 4-coumaryl-CoA + H2O <=> bisdemethoxycurcumin + 2 coenzyme A + carbon dioxide. [EC:2.3.1.219, GOC:pz]"}
{"concept_id": "C4328669", "aliases": [], "types": ["T044"], "canonical_name": "mycothiol-arsenate ligase activity", "definition": "Catalysis of the reaction: arsenate + mycothiol <=> mycothiol-arsenate conjugate + H2O. [EC:2.8.4.2, GOC:pz]"}
{"concept_id": "C4328670", "aliases": [], "types": ["T044"], "canonical_name": "FAD-dependent urate hydroxylase activity", "definition": "Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 <=> 5-hydroxyisouric acid + NAD + H2O. [EC:1.14.13.113, GOC:pz]"}
{"concept_id": "C4328671", "aliases": [], "types": ["T044"], "canonical_name": "(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity", "definition": "Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ <=> 3-dehydro-6-deoxoteasterone + NADP + H2O. [GOC:pz, RHEA:27325]"}
{"concept_id": "C4328672", "aliases": [], "types": ["T044"], "canonical_name": "decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity", "definition": "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol <=> dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+. [EC:2.4.1.289, GOC:pz]"}
{"concept_id": "C4328673", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol <=> S-adenosyl-L-homocysteine + H+ + a menaquinol. [GOC:pz, PMID:1444716, PMID:9045837, RHEA:26466]"}
{"concept_id": "C4328674", "aliases": [], "types": ["T044"], "canonical_name": "acrylate:acyl-coA CoA transferase activity", "definition": "Catalysis of the reaction: acryloyl-CoA + H2O <=> acrylate + coenzyme A + H+. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4328675", "aliases": [], "types": ["T044"], "canonical_name": "adrenaline O-methyltransferase activity", "definition": "Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine <=> metanephrine + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.6, GOC:pz]"}
{"concept_id": "C4328676", "aliases": [], "types": ["T044"], "canonical_name": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity", "definition": "Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP <=> H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4328677", "aliases": [], "types": ["T044"], "canonical_name": "N-benzoyl-L-glutamate synthetase activity", "definition": "Catalysis of the reaction: benzoate + L-glutamate + ATP <=> H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4328678", "aliases": [], "types": ["T044"], "canonical_name": "N-vanillate-L-glutamate synthetase activity", "definition": "Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP <=> H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4328679", "aliases": [], "types": ["T044"], "canonical_name": "N-(4-aminobenzoyl)-L-glutamate synthetase activity", "definition": "Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP <=> H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4328680", "aliases": [], "types": ["T044"], "canonical_name": "L-dopa O-methyltransferase activity", "definition": "Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine <=> 3-O-methyldopa + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.6, GOC:pz]"}
{"concept_id": "C4328681", "aliases": [], "types": ["T044"], "canonical_name": "7,8-dihydromonapterin aldolase activity", "definition": "Catalysis of the reaction: 7,8-dihydromonapterin <=> glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol. [GOC:pz, PMID:15107504]"}
{"concept_id": "C4328682", "aliases": [], "types": ["T044"], "canonical_name": "demethylrebeccamycin--D-glucose O-methyltransferase activity", "definition": "Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H+ + rebeccamycin + S-adenosyl-L-homocysteine. [EC:2.1.1.164, GOC:pz]"}
{"concept_id": "C4328683", "aliases": [], "types": ["T044"], "canonical_name": "homotaurine:2-oxoglutarate aminotransferase activity", "definition": "Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) <=> 3-sulfopropanal + L-glutamate(1-). [EC:2.6.1.-, GOC:pz]"}
{"concept_id": "C4328684", "aliases": [], "types": ["T044"], "canonical_name": "phenylacetyl-coenzyme A:glycine N-acyltransferase activity", "definition": "Catalysis of the reaction: phenylacetyl-CoA + glycine <=> H+ + phenylacetylglycine + coenzyme A. [EC:2.3.1.192, GOC:pz]"}
{"concept_id": "C4328686", "aliases": [], "types": ["T044"], "canonical_name": "oleamide hydrolase activity", "definition": "Catalysis of the reaction: oleamide + H2O <=> oleate + ammonium. [EC:3.5.1.99, GOC:pz]"}
{"concept_id": "C4328687", "aliases": [], "types": ["T044"], "canonical_name": "beta,beta-carotene-9',10'-cleaving oxygenase activity", "definition": "Catalysis of the reaction: beta-carotene + O2 <=> 10'-apo-beta-carotenal + beta-ionone. [EC:1.13.11.71, GOC:pz]"}
{"concept_id": "C4328688", "aliases": [], "types": ["T044"], "canonical_name": "OPC4-trans-2-enoyl-CoA hydratase activity", "definition": "Catalysis of the reaction: OPC4-3-hydroxyacyl-CoA <=> OPC4-trans-2-enoyl-CoA + H2O. [EC:4.2.1.17, GOC:pz]"}
{"concept_id": "C4328689", "aliases": [], "types": ["T044"], "canonical_name": "OPC6-trans-2-enoyl-CoA hydratase activity", "definition": "Catalysis of the reaction: OPC6-3-hydroxyacyl-CoA <=> OPC6-trans-2-enoyl-CoA + H2O. [EC:4.2.1.17, GOC:pz]"}
{"concept_id": "C4328690", "aliases": [], "types": ["T044"], "canonical_name": "OPC8-trans-2-enoyl-CoA hydratase activity", "definition": "Catalysis of the reaction: OPC8-3-hydroxyacyl-CoA <=> OPC8-trans-2-enoyl-CoA + H2O. [EC:4.2.1.17, GOC:pz]"}
{"concept_id": "C4328692", "aliases": [], "types": ["T044"], "canonical_name": "9,10-epoxy-18-hydroxystearate hydrolase activity", "definition": "Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O <=> 9,10,18-trihydroxystearate. [EC:3.3.2.-, GOC:pz]"}
{"concept_id": "C4328693", "aliases": [], "types": ["T044"], "canonical_name": "18-hydroxyoleate peroxygenase activity", "definition": "Catalysis of the reaction: 18-hydroxyoleate + a lipid hydroperoxide <=> 9,10-epoxy-18-hydroxystearate + a lipid alcohol. [GOC:pz, PMID:12226220, PMID:14535881, PMID:468835]"}
{"concept_id": "C4328694", "aliases": [], "types": ["T044"], "canonical_name": "zerumbone synthase activity", "definition": "Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD <=> zerumbone + NADH + H+. [EC:1.1.1.326, GOC:pz]"}
{"concept_id": "C4328695", "aliases": [], "types": ["T044"], "canonical_name": "alpha-humulene 10-hydroxylase activity", "definition": "Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ <=> 10-hydroxy-alpha-humulene + NADP + H2O. [EC:1.14.14.113, GOC:pz]"}
{"concept_id": "C4328696", "aliases": [], "types": ["T044"], "canonical_name": "geranylgeranyl diphosphate reductase activity", "definition": "Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+. [EC:1.3.1.83, GOC:pz]"}
{"concept_id": "C4328697", "aliases": [], "types": ["T044"], "canonical_name": "patchoulene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> diphosphoric acid + gamma-patchoulene. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328698", "aliases": [], "types": ["T044"], "canonical_name": "gamma-curcumene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> gamma-curcumene + diphosphoric acid. [EC:4.2.3.94, GOC:pz]"}
{"concept_id": "C4328699", "aliases": [], "types": ["T044"], "canonical_name": "beta-curcumene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (-)-beta-curcumene. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4328700", "aliases": [], "types": ["T044"], "canonical_name": "alpha-santalene synthase activity", "definition": "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphoric acid. [EC:4.2.3.50, GOC:pz]"}
{"concept_id": "C4328701", "aliases": ["(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)", "(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene", "endo-beta-bergamontene synthase activity"], "types": ["T044"], "canonical_name": "endo-beta-bergamotene synthase activity", "definition": "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphoric acid. [GOC:pz, RHEA:30467]"}
{"concept_id": "C4328702", "aliases": ["endo-alpha-bergamontene synthase activity"], "types": ["T044"], "canonical_name": "endo-alpha-bergamotene synthase activity", "definition": "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (-)-endo-alpha-bergamotene + diphosphoric acid. [GOC:pz, RHEA:30471]"}
{"concept_id": "C4328703", "aliases": [], "types": ["T044"], "canonical_name": "2-cis,6-cis-farnesyl pyrophosphate synthase activity", "definition": "Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> 2 diphosphate + (2Z,6Z)-farnesyl diphosphate. [GOC:pz, RHEA:27810]"}
{"concept_id": "C4328704", "aliases": [], "types": ["T044"], "canonical_name": "jasmonoyl-leucine synthetase activity", "definition": "Catalysis of the reaction: L-leucine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-leucine. [GOC:pz, PMID:17291501]"}
{"concept_id": "C4328705", "aliases": [], "types": ["T044"], "canonical_name": "jasmonoyl-valine synthetase activity", "definition": "Catalysis of the reaction: L-valine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-valine. [GOC:pz, PMID:17291501]"}
{"concept_id": "C4328706", "aliases": [], "types": ["T044"], "canonical_name": "maleylpyruvate hydrolase activity", "definition": "Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O <=> H+ + maleate(2-) + pyruvate. [GOC:pz, PMID:7400101, RHEA:47956]"}
{"concept_id": "C4328707", "aliases": [], "types": ["T044"], "canonical_name": "(-)-jasmonoyl-isoleucine synthetase activity", "definition": "Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid. [GOC:pz]"}
{"concept_id": "C4328708", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-proline synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) <=> H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4328709", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-tryptophan synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + L-tryptophan + ATP(4-) <=> H+ + indole-3-acetyl-tryptophan + AMP(2-) + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4328710", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-tyrosine synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) <=> H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4328711", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-methionine synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid. [GOC:pz, PMID:15659623]"}
{"concept_id": "C4328712", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-isoleucine synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid. [GOC:pz, PMID:15659623]"}
{"concept_id": "C4328713", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-glycine synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid. [GOC:pz, PMID:15659623]"}
{"concept_id": "C4328714", "aliases": [], "types": ["T044"], "canonical_name": "isopentenyl phosphate kinase activity", "definition": "Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-). [GOC:pz, PMID:19928876, RHEA:33963]"}
{"concept_id": "C4328715", "aliases": [], "types": ["T044"], "canonical_name": "alkylhydroperoxide reductase activity", "definition": "Catalysis of the reaction: H2O + NAD + an alcohol <=> NADH + H+ + an organic hydroperoxide. [GOC:pz, PMID:12517450]"}
{"concept_id": "C4328716", "aliases": [], "types": ["T044"], "canonical_name": "4-nitrobenzyl alcohol oxidase activity", "definition": "Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide. [GOC:pz]"}
{"concept_id": "C4328718", "aliases": [], "types": ["T045"], "canonical_name": "tRNA-guanine transglycosylation", "definition": "The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. [GOC:PomBase, GOC:vw, PMID:24911101]"}
{"concept_id": "C4328719", "aliases": ["negative regulation of surface tension of a liquid"], "types": ["T039"], "canonical_name": "negative regulation of liquid surface tension", "definition": "Any process that prevents or reduces the surface tension of a liquid. [GOC:sl, PMID:20949060]"}
{"concept_id": "C4328720", "aliases": ["positive regulation of surface tension of a liquid"], "types": ["T039"], "canonical_name": "positive regulation of liquid surface tension", "definition": "Any process that activates or increases the surface tension of a liquid. [GOC:sl, PMID:20949060]"}
{"concept_id": "C4328721", "aliases": [], "types": ["T042"], "canonical_name": "optical nerve axon regeneration", "definition": "The regrowth of axons of the optical nerve following their loss or damage. [GOC:pga, PMID:16699509]"}
{"concept_id": "C4328722", "aliases": ["nuclear membrane biogenesis involved in mitotic nuclear division"], "types": ["T043"], "canonical_name": "mitotic nuclear membrane biogenesis", "definition": "A process in which the nuclear inner or outer membrane is synthesized, aggregates, and bonds together during mitotic nuclear division. [GOC:vw, PMID:26869222]"}
{"concept_id": "C4328723", "aliases": [], "types": ["T043"], "canonical_name": "nuclear membrane biogenesis", "definition": "The process in which a nuclear membrane is synthesized, aggregates, and bonds together. [GOC:vw]"}
{"concept_id": "C4328724", "aliases": ["nuclear membrane organization involved in mitotic nuclear division"], "types": ["T043"], "canonical_name": "mitotic nuclear membrane organization", "definition": "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. [GOC:vw, PMID:15147872]"}
{"concept_id": "C4328725", "aliases": [], "types": ["T043"], "canonical_name": "vascular endothelial cell proliferation", "definition": "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774]"}
{"concept_id": "C4328726", "aliases": ["oestrogen 2-hydroxylase activity"], "types": ["T044"], "canonical_name": "estrogen 2-hydroxylase activity", "definition": "Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O. [GOC:BHF, GOC:rl, PMID:14559847]"}
{"concept_id": "C4328727", "aliases": ["oestrogen 16-alpha-hydroxylase activity"], "types": ["T044"], "canonical_name": "estrogen 16-alpha-hydroxylase activity", "definition": "Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O. [GOC:BHF]"}
{"concept_id": "C4328728", "aliases": ["negative regulation of late replication origin firing"], "types": ["T045"], "canonical_name": "negative regulation of mitotic DNA replication initiation from late origin", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication. [PMID:26436827]"}
{"concept_id": "C4328729", "aliases": ["regulation of late replication origin firing"], "types": ["T045"], "canonical_name": "regulation of mitotic DNA replication initiation from late origin", "definition": "Any process that modulates the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication. [PMID:26436827]"}
{"concept_id": "C4328730", "aliases": [], "types": ["T044"], "canonical_name": "intracellularly ATP-gated ion channel activity", "definition": "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. [PMID:9755289]"}
{"concept_id": "C4328731", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to protozoan", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. [GOC:dos]"}
{"concept_id": "C4328732", "aliases": [], "types": ["T040"], "canonical_name": "cheating during chimeric sorocarp development", "definition": "Any process during chimeric sorocarp development that increases by which a cell increases the number of spore cells sharing its genotype at the expense of cells of other genotypes. [PMID:18272966]"}
{"concept_id": "C4328733", "aliases": ["fully co-operative, chimeric sorocarp development"], "types": ["T040"], "canonical_name": "altruistic, chimeric sorocarp development", "definition": "Development of a chimeric sorocarp in which cells of all genotypes have an equal chance of becoming a spore cell. [PMID:18272966]"}
{"concept_id": "C4328734", "aliases": ["fully co-operative, chimeric, non-reproductive fruiting body development"], "types": ["T040"], "canonical_name": "altruistic, chimeric, non-reproductive fruiting body development", "definition": "Development of a chimeric, non-reproductive fruiting body in which cells of all genotypes have an equal chance of becoming a spore cell. [PMID:18272966]"}
{"concept_id": "C4328735", "aliases": [], "types": ["T040"], "canonical_name": "chimeric non-reproductive fruiting body development", "definition": "Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes. [PMID:18272966]"}
{"concept_id": "C4328736", "aliases": [], "types": ["T040"], "canonical_name": "chimeric sorocarp development", "definition": "Development of a sorocarp formed by aggregation of cells with different genotypes. [PMID:18272966]"}
{"concept_id": "C4328737", "aliases": [], "types": ["T043"], "canonical_name": "ATP hydrolysis coupled anion transmembrane transport"}
{"concept_id": "C4328738", "aliases": [], "types": ["T044"], "canonical_name": "ATP hydrolysis coupled cation transmembrane transport"}
{"concept_id": "C4328739", "aliases": [], "types": ["T044"], "canonical_name": "ATP hydrolysis coupled ion transmembrane transport"}
{"concept_id": "C4328740", "aliases": [], "types": ["T044"], "canonical_name": "estrogen binding", "definition": "Binding to an estrogen. [GOC:dos]"}
{"concept_id": "C4328741", "aliases": [], "types": ["T043"], "canonical_name": "cochlear outer hair cell electromotile response", "definition": "A rapid, force generating length change of an outer hair cell in response to electical stimulation. This occurs naturally as during hearing where it serves a source of mechanical amplification. [PMID:12239568, PMID:16887876, PMID:2187727]"}
{"concept_id": "C4328742", "aliases": ["envenomation resulting in positive regulation of argininosuccinate synthase activity in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in positive regulation of argininosuccinate synthase activity in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of the cytosolic argininosuccinate synthase in the bitten organism. [PMID:19491403]"}
{"concept_id": "C4328743", "aliases": ["axonal dopamine release", "axonal DA release"], "types": ["T043"], "canonical_name": "axonal dopamine secretion", "definition": "The regulated release of dopamine from an axon. [GOC:bf, GOC:PARL, PMID:21576241]"}
{"concept_id": "C4328744", "aliases": ["somatodendritic dopamine release", "STD DA release", "STD dopamine release"], "types": ["T043"], "canonical_name": "somato-dendritic dopamine secretion", "definition": "The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron. [GOC:bf, GOC:PARL, PMID:21576241]"}
{"concept_id": "C4328745", "aliases": ["RNAP II C-terminal binding"], "types": ["T044"], "canonical_name": "RNA polymerase II C-terminal domain binding", "definition": "Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function. [PMID:20889714]"}
{"concept_id": "C4328746", "aliases": [], "types": ["T040"], "canonical_name": "fungal sorus development", "definition": "The process whose specific outcome is the progression of a fungal sorus over time, from its formation to the mature structure. A fungal sorus is a spore containing structure. [GOC:dos]"}
{"concept_id": "C4328747", "aliases": ["socially co-operative development", "colonial development"], "types": ["T040"], "canonical_name": "socially cooperative development", "definition": "The process whose specific outcome is the progression of a non-reproductive fruiting body over time, from its formation to the mature structure. A non-reproductive fruiting body is a colonial multicellular structure consisting of co-operating unicellular organisms, some of which are spores. An example of such a process is found in Dictyostelium discoideum and Myxococcus xanthus colonies. [GOC:pf, PMID:12448714]"}
{"concept_id": "C4328748", "aliases": [], "types": ["T044"], "canonical_name": "3-demethylubiquinol-8 3-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8. [GOC:ic]"}
{"concept_id": "C4328749", "aliases": [], "types": ["T043"], "canonical_name": "protein transport along microtubule to cell tip", "definition": "The movement of a protein along a microtubule to the cell-tip, mediated by motor proteins. [PMID:15177031]"}
{"concept_id": "C4328750", "aliases": ["tRNA 5' processing"], "types": ["T045"], "canonical_name": "tRNA 5'-end processing", "definition": "The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA. [GOC:dos, GOC:pf, PMID:27484477]"}
{"concept_id": "C4328751", "aliases": ["subtelomere"], "types": ["T026"], "canonical_name": "chromosome, subtelomeric region", "definition": "A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin. [GOC:mah, PMID:18761674, PMID:22771823, PMID:26205977, PMID:7660126]"}
{"concept_id": "C4328752", "aliases": [], "types": ["T045"], "canonical_name": "chromatin silencing at subtelomere"}
{"concept_id": "C4328753", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of presynaptic cytosolic calcium concentration", "definition": "Any process that decreases the concentration of calcium ions in the presynaptic cytosol. [GOC:dos]"}
{"concept_id": "C4328754", "aliases": [], "types": ["T043"], "canonical_name": "microtubule polymerization based protein transport", "definition": "The transport of a protein driven by polymerization of a microtubule to which it is attached. [GOC:dos, GOC:vw, PMID:11018050]"}
{"concept_id": "C4328755", "aliases": [], "types": ["T043"], "canonical_name": "microtubule polymerization based protein transport to cell tip cortex", "definition": "The transport of a protein to the cortex of the cell tip, driven by polymerization of a microtubule to which the protein is attached. [GOC:dos, GOC:vw, PMID:11018050]"}
{"concept_id": "C4328756", "aliases": ["potassium channel activating, G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "potassium channel activating, G protein-coupled receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel. [GOC:dos, PMID:9429760]"}
{"concept_id": "C4328757", "aliases": ["potassium channel activator activity involved in G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "potassium channel activator activity involved in G protein-coupled receptor signaling pathway", "definition": "Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling. [PMID:9429760]"}
{"concept_id": "C4328758", "aliases": ["ion channel regulator activity involved in G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "ion channel regulator activity involved in G protein-coupled receptor signaling pathway", "definition": "Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling. [GOC:dos]"}
{"concept_id": "C4328759", "aliases": [], "types": ["T044"], "canonical_name": "ion channel regulator activity", "definition": "Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. [GOC:dos]"}
{"concept_id": "C4328760", "aliases": ["ion channel modulating, G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "ion channel modulating, G protein-coupled receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel. [GOC:dos]"}
{"concept_id": "C4328761", "aliases": [], "types": ["T044"], "canonical_name": "potassium channel activator activity", "definition": "Binds to and increases the activity of a potassium channel, resulting in its opening. [GOC:dos]"}
{"concept_id": "C4328762", "aliases": ["channel gating activity"], "types": ["T044"], "canonical_name": "channel activator activity", "definition": "Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. [GOC:dos]"}
{"concept_id": "C4328763", "aliases": [], "types": ["T044"], "canonical_name": "G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential", "definition": "Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential. [GOC:dos, PMID:9429760]"}
{"concept_id": "C4328764", "aliases": [], "types": ["T044"], "canonical_name": "G-protein gated potassium channel activity", "definition": "A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer. [GOC:dos, PMID:9429760]"}
{"concept_id": "C4328765", "aliases": [], "types": ["T044"], "canonical_name": "G-protein gated cation channel activity", "definition": "A cation channel activity that is gated by binding of a G-protein beta-gamma dimer. [GOC:dos]"}
{"concept_id": "C4328766", "aliases": [], "types": ["T044"], "canonical_name": "G-protein gated ion channel activity", "definition": "An ion channel activity that is gated by binding of a G-protein beta-gamma dimer. [GOC:dos]"}
{"concept_id": "C4328767", "aliases": [], "types": ["T043"], "canonical_name": "microtubule polymerization based movement", "definition": "The movement of a cellular component as a result of microtubule polymerization. [GOC:cjm, ISBN:0815316194]"}
{"concept_id": "C4328768", "aliases": [], "types": ["T043"], "canonical_name": "prospore membrane biogenesis"}
{"concept_id": "C4328769", "aliases": [], "types": ["T026"], "canonical_name": "vestibular calyx terminal", "definition": "The giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell. [PMID:10706428, PMID:25355208]"}
{"concept_id": "C4328770", "aliases": [], "types": ["T044"], "canonical_name": "ligand-gated anion channel activity", "definition": "Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C4328771", "aliases": [], "types": ["T044"], "canonical_name": "ligand-gated cation channel activity", "definition": "Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C4328772", "aliases": ["mitochondrial calcium release", "calcium ion transmembrane export from mitochondrion"], "types": ["T043"], "canonical_name": "calcium export from the mitochondrion", "definition": "A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol. [GOC:dos, GOC:vw]"}
{"concept_id": "C4328773", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic density, intracellular component", "definition": "A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:dos]"}
{"concept_id": "C4328774", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic specialization, intracellular component", "definition": "A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:dos]"}
{"concept_id": "C4328776", "aliases": ["axonal transport of mRNA RNP complex"], "types": ["T043"], "canonical_name": "axonal transport of messenger ribonucleoprotein complex", "definition": "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons. [GOC:dos, PMID:26586091]"}
{"concept_id": "C4328777", "aliases": ["anterograde axonal transport of mRNA RNP complex"], "types": ["T043"], "canonical_name": "anterograde axonal transport of messenger ribonucleoprotein complex", "definition": "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse. [GOC:dos, PMID:26586091]"}
{"concept_id": "C4328778", "aliases": [], "types": ["T026"], "canonical_name": "synaptonemal structure", "definition": "A proteinaceous scaffold found between homologous chromosomes during meiosis. [GOC:elh, GOC:vw]"}
{"concept_id": "C4328779", "aliases": ["differentiation-inducing factor dechlorinase activity", "differentiation-inducing factor 1 dechlorinase activity", "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one 3(5)-dechlorinase activity", "1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one 3(5)-dechlorinase activity", "DIF-1 3(5)-dechlorinase activity", "DIF-1 dechlorinase activity"], "types": ["T044"], "canonical_name": "DIF dechlorinase activity", "definition": "Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-. [PMID:1521542, PMID:22035794]"}
{"concept_id": "C4328780", "aliases": [], "types": ["T043"], "canonical_name": "retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission", "definition": "Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]"}
{"concept_id": "C4328781", "aliases": [], "types": ["T043"], "canonical_name": "retrograde trans-synaptic signaling by neuropeptide", "definition": "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]"}
{"concept_id": "C4328782", "aliases": [], "types": ["T026"], "canonical_name": "supramolecular polymer", "definition": "A polymeric supramolecular structure. [GOC:dos]"}
{"concept_id": "C4328783", "aliases": [], "types": ["T026"], "canonical_name": "actin body", "definition": "An amorphous cytoskeletal structure consisting of aggregated actin filaments and associated proteins (including fibrin and capping protein) in which there is little or no actin filament turnover. In yeast (S. pombe and S. cerevisiae) these are found only in quiescent cells and are thought to serve as a reserve store of actin. [PMID:16914523]"}
{"concept_id": "C4328784", "aliases": [], "types": ["T045"], "canonical_name": "histone-dependent DNA binding", "definition": "DNA-binding activity that is dependent on binding to a histone. [PMID:11691835]"}
{"concept_id": "C4328785", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrion to peroxisome transport", "definition": "Transport from the mitochondrion to the peroxisome, mediated by mitochondrion-derived vesicles. [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655]"}
{"concept_id": "C4328786", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrion-derived vesicle mediated transport", "definition": "Transport from the mitochondrion, mediated by mitochondrion derived vesicles. [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:2061965, PMID:20619655]"}
{"concept_id": "C4328787", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrion to lysosome transport", "definition": "Transport from the mitochondrion to the lysosome, mediated by mitochondrion-derived vesicles. [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655]"}
{"concept_id": "C4328788", "aliases": [], "types": ["T043"], "canonical_name": "regulation of postsynaptic membrane neurotransmitter receptor levels", "definition": "Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane. [GOC:dos]"}
{"concept_id": "C4328789", "aliases": [], "types": ["T026"], "canonical_name": "dynamic microtubule bundle", "definition": "A microtubule bundle that undergoes changes in length, and in which microtubule sliding takes place. [GOC:vw, PMID:26124291]"}
{"concept_id": "C4328790", "aliases": [], "types": ["T026"], "canonical_name": "static microtubule bundle", "definition": "A microtubule bundle that has a constant length, and in which microtubule sliding does not take place. [GOC:vw, PMID:26124291]"}
{"concept_id": "C4328791", "aliases": [], "types": ["T043"], "canonical_name": "synaptic vesicle tethering involved in synaptic vesicle exocytosis", "definition": "The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion. [GOC:rn]"}
{"concept_id": "C4328792", "aliases": ["postsynapse biogenesis"], "types": ["T043"], "canonical_name": "postsynapse assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a postsynapse. [GOC:bf, GOC:dos, GOCL:PARL]"}
{"concept_id": "C4328793", "aliases": [], "types": ["T026"], "canonical_name": "integral component of presynaptic endosome membrane", "definition": "The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328794", "aliases": [], "types": ["T026"], "canonical_name": "integral component of spine apparatus membrane", "definition": "The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328795", "aliases": [], "types": ["T026"], "canonical_name": "integral component of postsynaptic endosome membrane", "definition": "The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328796", "aliases": [], "types": ["T026"], "canonical_name": "integral component of postsynaptic recycling endosome membrane", "definition": "The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328797", "aliases": [], "types": ["T026"], "canonical_name": "integral component of postsynaptic early endosome membrane", "definition": "The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328798", "aliases": [], "types": ["T026"], "canonical_name": "integral component of postsynaptic density membrane", "definition": "The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328799", "aliases": [], "types": ["T026"], "canonical_name": "integral component of postsynaptic specialization membrane", "definition": "The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328800", "aliases": [], "types": ["T026"], "canonical_name": "integral component of presynaptic active zone membrane", "definition": "The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328801", "aliases": [], "types": ["T026"], "canonical_name": "integral component of postsynaptic endocytic zone membrane", "definition": "The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328802", "aliases": [], "types": ["T026"], "canonical_name": "integral component of presynaptic endocytic zone membrane", "definition": "The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328803", "aliases": ["integral component of presynaptic plasma membrane"], "types": ["T026"], "canonical_name": "integral component of presynaptic membrane", "definition": "The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328804", "aliases": [], "types": ["T026"], "canonical_name": "integral component of postsynaptic membrane", "definition": "The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4328805", "aliases": ["presynaptic terminal assembly", "presynapse biogenesis"], "types": ["T043"], "canonical_name": "presynapse assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a presynapse. [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494]"}
{"concept_id": "C4328806", "aliases": [], "types": ["T043"], "canonical_name": "vesicle scission involved in clathrin-mediated endocytosis", "definition": "The membrane scission process that is the final step in the formation of a clathrin-coated endocytic vesicle: separation from the plasma membrane. [PMID:21779028]"}
{"concept_id": "C4328807", "aliases": [], "types": ["T043"], "canonical_name": "vesicle scission involved in endocytosis", "definition": "The membrane scission process that is the final step in the formation of an endocytic vesicle: separation from the plasma membrane. [PMID:21779028]"}
{"concept_id": "C4328808", "aliases": [], "types": ["T043"], "canonical_name": "clathrin coat assembly involved in endocytosis", "definition": "The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation. [PMID:21779028]"}
{"concept_id": "C4328809", "aliases": [], "types": ["T043"], "canonical_name": "clearance of foreign intracellular RNA", "definition": "A defense process that protects an organism from invading foreign RNA. [GO:dos]"}
{"concept_id": "C4328810", "aliases": [], "types": ["T043"], "canonical_name": "clearance of foreign intracellular nucleic acids", "definition": "A defense process that protects an organism from DNA or RNA from an invading organism. [GO:dos]"}
{"concept_id": "C4328811", "aliases": [], "types": ["T043"], "canonical_name": "viral extrusion", "definition": "The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded. [PMID:15567492, VZ:3951]"}
{"concept_id": "C4328812", "aliases": [], "types": ["T043"], "canonical_name": "vesicle tethering to endoplasmic reticulum", "definition": "The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion. [PMID:27243008]"}
{"concept_id": "C4328813", "aliases": [], "types": ["T044"], "canonical_name": "cargo loading involved in clathrin-dependent endocytosis", "definition": "Formation of a macromolecular complex during clathrin-dependent endocytosis that connects the assembling clathrin coat to the proteins and/or lipoproteins to be transported in an endocytic vesicle. This complex includes a receptor and an adaptor protein that links the receptor to the clathrin coat. [GOC:dos, GOC:lb, GOC:vw, PMID:21779028]"}
{"concept_id": "C4328814", "aliases": [], "types": ["T043"], "canonical_name": "nucleation of clathrin-coated pit", "definition": "The first step in clathrin-dependent endocytosis: invagination of the plasma membrane to form a pit. [GOC:dos, GOC:vw, PMID:21779028]"}
{"concept_id": "C4328815", "aliases": [], "types": ["T043"], "canonical_name": "vesicle tethering to Golgi", "definition": "The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion. [PMID:27243008]"}
{"concept_id": "C4328816", "aliases": [], "types": ["T043"], "canonical_name": "ceramide translocation", "definition": "The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet. [GOC:BHF, GOC:rl]"}
{"concept_id": "C4328817", "aliases": [], "types": ["T043"], "canonical_name": "sphingolipid translocation", "definition": "The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. [GOC:BHF, GOC:rl]"}
{"concept_id": "C4328818", "aliases": [], "types": ["T044"], "canonical_name": "ceramide-translocating ATPase activity"}
{"concept_id": "C4328819", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of presynaptic endosome membrane", "definition": "The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328820", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of neuronal dense core vesicle membrane", "definition": "The component of the neuronal dense core vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328821", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of spine apparatus membrane", "definition": "The component of the spine apparatus membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328822", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of postsynaptic endosome membrane", "definition": "The component of the postsynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328823", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of postsynaptic recycling endosome membrane", "definition": "The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328824", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of postsynaptic early endosome membrane", "definition": "The component of the postsynaptic early endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328825", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of postsynaptic density membrane", "definition": "The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328826", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of postsynaptic specialization membrane", "definition": "The component of the postsynaptic specialization membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328827", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of presynaptic active zone membrane", "definition": "The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328828", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of postynaptic endocytic zone membrane", "definition": "The component of the postynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328829", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of presynaptic endocytic zone membrane", "definition": "The component of the presynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328830", "aliases": ["anchored component of presynaptic plasma membrane"], "types": ["T026"], "canonical_name": "anchored component of presynaptic membrane", "definition": "The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328831", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of postsynaptic membrane", "definition": "The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328832", "aliases": [], "types": ["T043"], "canonical_name": "vesicle tethering", "definition": "The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion. [PMID:27243008]"}
{"concept_id": "C4328833", "aliases": [], "types": ["T026"], "canonical_name": "cortical endoplasmic reticulum lumen", "definition": "The volume enclosed by the membranes of the cortical endoplasmic reticulum. [GOC:dos, GOC:vw]"}
{"concept_id": "C4328834", "aliases": [], "types": ["T026"], "canonical_name": "perinuclear endoplasmic reticulum lumen", "definition": "The volume enclosed by the membranes of the perinuclear endoplasmic reticulum. [GOC:dos, GOC:vw]"}
{"concept_id": "C4328835", "aliases": ["restriction-modification system evasion by virus"], "types": ["T043"], "canonical_name": "evasion by virus of host restriction-modification system", "definition": "Any process, either active or passive, by which a virus evades the DNA restriction modification system of its host. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction. [PMID:20348932, PMID:23979432, PMID:24123737, VZ:3966]"}
{"concept_id": "C4328836", "aliases": ["DNA end degradation evasion by virus"], "types": ["T043"], "canonical_name": "evasion by virus of DNA end degradation", "definition": "A process by which a virus evades and ends degradation of its DNA when free viral-DNA ends are exposed as part of its life-cycle. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases. [GOC:dos]"}
{"concept_id": "C4328837", "aliases": [], "types": ["T043"], "canonical_name": "degradation of host chromosome by virus", "definition": "The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis. [PMID:163355, PMID:335083, PMID:3972821, PMID:5263754, VZ:3947]"}
{"concept_id": "C4328838", "aliases": [], "types": ["T043"], "canonical_name": "neuronal dense core vesicle organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle. [GOC:dos]"}
{"concept_id": "C4328839", "aliases": [], "types": ["T026"], "canonical_name": "neuronal dense core vesicle lumen", "definition": "The volume enclosed by a neuronal dense core vesicle membrane. [GOC:dos]"}
{"concept_id": "C4328840", "aliases": [], "types": ["T026"], "canonical_name": "neuronal dense core vesicle membrane", "definition": "The lipid bilayer surrounding a neuronal dense core vesicle. [GOC:dos]"}
{"concept_id": "C4328841", "aliases": [], "types": ["T043"], "canonical_name": "neuronal dense core vesicle exocytosis", "definition": "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels. [GOC:kmv, PMID:17553987, PMID:24653208]"}
{"concept_id": "C4328842", "aliases": [], "types": ["T045"], "canonical_name": "viral genome circularization", "definition": "The circularization of a viral genome following infection of a host cell. This is common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome. It can be mediated by covalent closure of the DNA sticky ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities. [PMID:11894948, PMID:15489417, PMID:19523475, PMID:319596, VZ:3968]"}
{"concept_id": "C4328843", "aliases": [], "types": ["T043"], "canonical_name": "viral entry via permeabilization of inner membrane", "definition": "The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane. [PMID:15795287, PMID:20427561, VZ:985]"}
{"concept_id": "C4328844", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of presynaptic endosome membrane", "definition": "The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328845", "aliases": [], "types": ["T043"], "canonical_name": "viral entry via permeabilization of endosomal membrane", "definition": "The entry of a non-enveloped virus into a host eukaryotic cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) associated with the viral capsid. In some cases, viral membrane-penetration protein require first to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen. [PMID:15329727, PMID:25055856, VZ:985]"}
{"concept_id": "C4328846", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of postsynaptic recycling endosome membrane", "definition": "The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328847", "aliases": ["CAMK signaling pathway"], "types": ["T043"], "canonical_name": "calmodulin dependent kinase signaling pathway", "definition": "Any signal transduction pathway involving calmodulin dependent kinase activity. [GOC:dos]"}
{"concept_id": "C4328848", "aliases": [], "types": ["T043"], "canonical_name": "vesicle-mediated transport in synapse", "definition": "Any vesicle-mediated transport that occurs in a synapse. [GOC:dos]"}
{"concept_id": "C4328849", "aliases": ["viral short tail ejection system"], "types": ["T043"], "canonical_name": "viral genome ejection through host cell envelope, short tail mechanism", "definition": "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties. [GOC:dos, PMID:22297513, VZ:3954]"}
{"concept_id": "C4328850", "aliases": ["viral long flexible tail ejection system"], "types": ["T043"], "canonical_name": "viral genome ejection through host cell envelope, long flexible tail mechanism", "definition": "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm. [GOC:dos, PMID:22297512, VZ:3952]"}
{"concept_id": "C4328851", "aliases": ["viral contractile tail ejection system"], "types": ["T043"], "canonical_name": "viral genome ejection through host cell envelope, contractile tail mechanism", "definition": "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope. [GOC:dos, PMID:26283379, VZ:3950]"}
{"concept_id": "C4328852", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of postsynaptic endosome membrane", "definition": "The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328853", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of postsynaptic early endosome membrane", "definition": "The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328854", "aliases": ["viral envelope fusion with host outer membrane"], "types": ["T043"], "canonical_name": "fusion of virus membrane with host outer membrane", "definition": "Fusion of a viral membrane with the host cell outer membrane during viral entry. [GOC:dos, VZ:3941]"}
{"concept_id": "C4328855", "aliases": ["degradation of host capsule during virus entry", "degradation of host glycocalyx during viral entry", "catabolism of host glycocalyx during viral entry", "disassembly of glycocalyx during viral entry"], "types": ["T043"], "canonical_name": "disruption of host cell glycocalyx during viral entry", "definition": "The disruption of host cell glycocalyx by viral proteins during virus entry. [GOC:dos]"}
{"concept_id": "C4328856", "aliases": ["degradation of host lipopolysaccharide during virus entry", "degradation of host cell envelope lipopolysaccharide during viral entry"], "types": ["T043"], "canonical_name": "disruption by virus of host envelope lipopolysaccharide during virus entry", "definition": "The breakdown of lipopolysaccharides in a host cell envelope during virus entry into a host cell. For example a phage entering a gram-negative bacterium may actively break down outer membrane lipopolysaccharides. [GOC:dos, VZ:3940]"}
{"concept_id": "C4328857", "aliases": [], "types": ["T043"], "canonical_name": "disruption of host cell envelope during viral entry", "definition": "The disruption of host cell envelope by viral proteins during virus entry. [GOC:dos]"}
{"concept_id": "C4328858", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of synaptic vesicle membrane", "definition": "The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4328859", "aliases": [], "types": ["T026"], "canonical_name": "neuronal dense core vesicle", "definition": "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176]"}
{"concept_id": "C4328860", "aliases": [], "types": ["T043"], "canonical_name": "kainate selective glutamate receptor signaling pathway", "definition": "The series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:9780071120005]"}
{"concept_id": "C4328861", "aliases": [], "types": ["T043"], "canonical_name": "AMPA selective glutamate receptor signaling pathway", "definition": "The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dos, ISBN:9780071120005]"}
{"concept_id": "C4328862", "aliases": [], "types": ["T043"], "canonical_name": "NMDA selective glutamate receptor signaling pathway", "definition": "The series of molecular signals initiated by glutamate binding to an NMDA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dos, ISBN:9780071120005]"}
{"concept_id": "C4328863", "aliases": ["G-protein coupled glutamate receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled glutamate receptor activity", "definition": "Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity. [GOC:dos]"}
{"concept_id": "C4328864", "aliases": [], "types": ["T043"], "canonical_name": "regulation of modification of synapse structure, modulating synaptic transmission", "definition": "Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission. [GOC:dos]"}
{"concept_id": "C4328865", "aliases": [], "types": ["T030"], "canonical_name": "asymmetric, glutamatergic, excitatory synapse", "definition": "A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials. [GOC:dos]"}
{"concept_id": "C4328866", "aliases": [], "types": ["T030"], "canonical_name": "neuron to neuron synapse", "definition": "A synapse in which pre and post-synaptic cells are neurons. [GOC:dos]"}
{"concept_id": "C4328867", "aliases": [], "types": ["T030"], "canonical_name": "symmetric, GABA-ergic, inhibitory synapse", "definition": "A neuron to neuron synapse that lacks an electron dense postsynaptic specialization, uses GABA as a neurotransmitter and whose activity results in inhibitory postsynaptic potentials. [GOC:dos]"}
{"concept_id": "C4328868", "aliases": [], "types": ["T030"], "canonical_name": "GABA-ergic synapse", "definition": "A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. [GOC:dos]"}
{"concept_id": "C4328869", "aliases": [], "types": ["T030"], "canonical_name": "cholinergic synapse", "definition": "A synapse that uses acetylcholine as a neurotransmitter. [GOC:dos]"}
{"concept_id": "C4328870", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic density", "definition": "An electron dense specialization of the presynaptic active zone cytoskeleton. [GOC:dos, PMID:26780543]"}
{"concept_id": "C4328871", "aliases": [], "types": ["T030"], "canonical_name": "polyadic synapse", "definition": "A synapse consisting of a single presynapse and multiple postsynapses. These postsynapses may come from the same cell of from different cells. Polyadic synapses are common in arthropod and nematode central nervous systems. [PMID:26780543]"}
{"concept_id": "C4328872", "aliases": [], "types": ["T030"], "canonical_name": "glutamatergic synapse", "definition": "A synapse that uses glutamate as a neurotransmitter. [GOC:dos]"}
{"concept_id": "C4328873", "aliases": [], "types": ["T043"], "canonical_name": "inhibitory chemical synaptic transmission", "definition": "Synaptic transmission that results in an inhibitory postsynaptic potential. [GOC:dos]"}
{"concept_id": "C4328874", "aliases": [], "types": ["T043"], "canonical_name": "excitatory chemical synaptic transmission", "definition": "Synaptic transmission that results in an excitatory postsynaptic potential. [GOC:dos]"}
{"concept_id": "C4328875", "aliases": [], "types": ["T026"], "canonical_name": "postsynapse of neuromuscular junction", "definition": "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma. [GOC:dos, Wikipedia:Neuromuscular_junction&oldid=723623502]"}
{"concept_id": "C4328876", "aliases": [], "types": ["T043"], "canonical_name": "postsynaptic actin cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. [GOC:dos]"}
{"concept_id": "C4328877", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of postsynaptic actin cytoskeleton", "definition": "The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton. [GOC:dos]"}
{"concept_id": "C4328878", "aliases": [], "types": ["T043"], "canonical_name": "anterograde dendritic transport of neurotransmitter receptor complex", "definition": "The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse. [GOC:dos]"}
{"concept_id": "C4328879", "aliases": [], "types": ["T043"], "canonical_name": "postsynaptic neurotransmitter receptor diffusion trapping", "definition": "The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization. [PMID:18832033]"}
{"concept_id": "C4328880", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter receptor transport to postsynaptic membrane", "definition": "The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles. [GOC:dos]"}
{"concept_id": "C4328881", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter receptor transport postsynaptic membrane to endosome", "definition": "Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome. [GOC:dos]"}
{"concept_id": "C4328882", "aliases": [], "types": ["T043"], "canonical_name": "exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "definition": "The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion. [PMID:19503082]"}
{"concept_id": "C4328883", "aliases": ["ECM of synaptic cleft", "synaptic cleft ECM"], "types": ["T026"], "canonical_name": "extracellular matrix of synaptic cleft", "definition": "The portion of the extracellular matrix that lies within the synaptic cleft. [GOC:dos]"}
{"concept_id": "C4328884", "aliases": ["anterograde dendritic transport of mRNA RNP complex"], "types": ["T043"], "canonical_name": "anterograde dendritic transport of messenger ribonucleoprotein complex", "definition": "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse. [GOC:dos]"}
{"concept_id": "C4328885", "aliases": ["dendritic transport of mRNA RNP complex"], "types": ["T043"], "canonical_name": "dendritic transport of messenger ribonucleoprotein complex", "definition": "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites. [GOC:dos]"}
{"concept_id": "C4328886", "aliases": [], "types": ["T042"], "canonical_name": "regulation of postsynaptic neurotransmitter receptor activity", "definition": "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. [GOC:dos]"}
{"concept_id": "C4328887", "aliases": ["dendritic transport of RNP complex"], "types": ["T043"], "canonical_name": "dendritic transport of ribonucleoprotein complex", "definition": "The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites. [GOC:dos]"}
{"concept_id": "C4328888", "aliases": ["neurotransmitter receptor activity involved in chemical synaptic transmission"], "types": ["T044"], "canonical_name": "postsynaptic neurotransmitter receptor activity", "definition": "Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission. [GOC:dos, GOC:signaling]"}
{"concept_id": "C4328889", "aliases": ["intrinsic to presynaptic endosome membrane"], "types": ["T026"], "canonical_name": "intrinsic component of presynaptic endosome membrane", "definition": "The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328890", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic endosome membrane", "definition": "The lipid bilayer surrounding a presynaptic endosome. [GOC:pz]"}
{"concept_id": "C4328891", "aliases": [], "types": ["T043"], "canonical_name": "receptor diffusion trapping", "definition": "The process by which a membrane receptor, diffusing freely within the plasma membeane, becomes trapped in some plasma membrane region. This can happen when a receptor bind, directly or indirectly, to some component of the underlying matrix. [PMID:18832033]"}
{"concept_id": "C4328892", "aliases": ["intrinsic to spine apparatus membrane"], "types": ["T026"], "canonical_name": "intrinsic component of spine apparatus membrane", "definition": "The component of the spine apparatus membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328893", "aliases": ["intrinsic to postsynaptic recycling endosome membrane"], "types": ["T026"], "canonical_name": "intrinsic component of postsynaptic recycling endosome membrane", "definition": "The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328894", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of postsynaptic early endosome membrane", "definition": "The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328895", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of postsynaptic endosome membrane", "definition": "The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328896", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of postsynaptic specialization membrane", "definition": "The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328897", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of postsynaptic endocytic zone membrane", "definition": "The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328898", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of presynaptic endocytic zone membrane", "definition": "The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328899", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of presynaptic active zone membrane", "definition": "The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328900", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic recycling endosome membrane", "definition": "The lipid bilayer surrounding a postsynaptic recycling endosome. [GOC:pz]"}
{"concept_id": "C4328901", "aliases": [], "types": ["T043"], "canonical_name": "dendritic transport of mitochondrion", "definition": "The directed movement of mitochondria along microtubules in nerve cell dendrites. [GOC:ai]"}
{"concept_id": "C4328902", "aliases": [], "types": ["T043"], "canonical_name": "anterograde dendritic transport", "definition": "The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites. [ISBN:0815316194]"}
{"concept_id": "C4328903", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of postsynaptic membrane", "definition": "The component of the postsynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328904", "aliases": ["dendrite cargo transport"], "types": ["T043"], "canonical_name": "dendritic transport", "definition": "The directed movement of organelles or molecules along microtubules in dendrites. [ISBN:0815316194]"}
{"concept_id": "C4328905", "aliases": [], "types": ["T043"], "canonical_name": "retrograde dendritic transport", "definition": "The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body. [GOC:dos]"}
{"concept_id": "C4328906", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of spine apparatus membrane", "definition": "The component of the spine apparatus membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]"}
{"concept_id": "C4328907", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of dense core granule membrane", "definition": "The component of the dense core granule membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]"}
{"concept_id": "C4328908", "aliases": [], "types": ["T026"], "canonical_name": "spine apparatus lumen", "definition": "The volume enclosed by the spine apparatus membrane. [GOC:dos]"}
{"concept_id": "C4328909", "aliases": ["dense core vesicle lumen"], "types": ["T026"], "canonical_name": "dense core granule lumen", "definition": "The volume enclosed by the dense core granule membrane. [GOC:dos]"}
{"concept_id": "C4328910", "aliases": [], "types": ["T026"], "canonical_name": "spine apparatus membrane", "definition": "The lipid bilayer surrounding the spine apparatus. [GOC:mah]"}
{"concept_id": "C4328911", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic early endosome membrane", "definition": "The lipid bilayer surrounding a postsynaptic early endosome. [GOC:pz]"}
{"concept_id": "C4328912", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic endosome membrane", "definition": "The lipid bilayer surrounding a postsynaptic endosome. [GOC:pz]"}
{"concept_id": "C4328913", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of presynaptic endocytic zone membrane", "definition": "The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328914", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of postsynaptic endocytic zone", "definition": "The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328915", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of postsynaptic specialization membrane", "definition": "The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328916", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of presynaptic active zone membrane", "definition": "The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328917", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of postsynaptic membrane", "definition": "The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328918", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of presynaptic membrane", "definition": "The component of the presynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4328919", "aliases": ["extrinsic component of presynaptic plasma membrane"], "types": ["T026"], "canonical_name": "extrinsic component of presynaptic membrane", "definition": "The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4328920", "aliases": [], "types": ["T043"], "canonical_name": "modification of dendritic spine", "definition": "Any process that modifies the structure of a dendritic spine. [GOC:dos]"}
{"concept_id": "C4328921", "aliases": ["postsynaptic actin cytoskeleton remodelling"], "types": ["T043"], "canonical_name": "modification of postsynaptic actin cytoskeleton", "definition": "Any process that modifies the structure of a postsynaptic actin cytoskeleton. [GOC:dos]"}
{"concept_id": "C4328922", "aliases": ["synapse clearance", "synapse removal", "synapse elimination", "synapse disassembly"], "types": ["T043"], "canonical_name": "synapse pruning", "definition": "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190]"}
{"concept_id": "C4328923", "aliases": ["structural constituent of active zone"], "types": ["T044"], "canonical_name": "structural constituent of presynaptic active zone", "definition": "The action of a molecule that contributes to the structural integrity of a presynaptic active zone. [GOC:dos]"}
{"concept_id": "C4328924", "aliases": ["neurotransmitter receptor insertion"], "types": ["T043"], "canonical_name": "exocytic insertion of neurotransmitter receptor to plasma membrane", "definition": "The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion. [GOC:aruk, GOC:bc, PMID:19503082]"}
{"concept_id": "C4328925", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of postsynaptic specialization structure", "definition": "A process which maintains the organization and the arrangement of proteins in the presynaptic specialization. [GOC:dos]"}
{"concept_id": "C4328926", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of postsynaptic specialization", "definition": "The action of a molecule that contributes to the structural integrity of a postsynaptic specialization. [GOC:dos]"}
{"concept_id": "C4328927", "aliases": [], "types": ["T043"], "canonical_name": "neurotransmitter receptor transport to plasma membrane", "definition": "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles. [GOC:dos]"}
{"concept_id": "C4328928", "aliases": [], "types": ["T043"], "canonical_name": "vesicle-mediated transport to the plasma membrane", "definition": "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. [GOC:dos]"}
{"concept_id": "C4328929", "aliases": [], "types": ["T026"], "canonical_name": "non-motile cilium membrane", "definition": "The portion of the plasma membrane surrounding a non-motile cilium. [GOC:cilia, GOC:dos]"}
{"concept_id": "C4328930", "aliases": [], "types": ["T043"], "canonical_name": "postsynaptic specialization assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane. [GOC:dos]"}
{"concept_id": "C4328931", "aliases": [], "types": ["T044"], "canonical_name": "ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels", "definition": "Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. [GOC:dos]"}
{"concept_id": "C4328932", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "definition": "Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. [GOC:dos]"}
{"concept_id": "C4328933", "aliases": ["IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels"], "types": ["T044"], "canonical_name": "inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels", "definition": "Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. [GOC:dos]"}
{"concept_id": "C4328934", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle budding from presynaptic endocytic zone membrane", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane. [GOC:dos]"}
{"concept_id": "C4328935", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic vesicle cycle", "definition": "Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle. [GOC:dos]"}
{"concept_id": "C4328936", "aliases": [], "types": ["T030"], "canonical_name": "noradrenergic synapse", "definition": "A synapse that uses noradrenaline as a neurotransmitter. [GOC:dos]"}
{"concept_id": "C4328937", "aliases": [], "types": ["T030"], "canonical_name": "dopaminergic synapse", "definition": "A synapse that uses dopamine as a neurotransmitter. [GOC:dos]"}
{"concept_id": "C4328938", "aliases": [], "types": ["T030"], "canonical_name": "glycinergic synapse", "definition": "A synapse that uses glycine as a neurotransmitter. [GOC:dos]"}
{"concept_id": "C4328939", "aliases": ["proviral switch", "Latency-replication switch", "lytic switch", "proviral induction", "reactivation of latent virus"], "types": ["T043"], "canonical_name": "latency-replication decision", "definition": "The process by which a virus switches on its replication cycle in an infected cell. The process is typically controlled by a genetic swtich controlled by environmental factors such as cell type, cell shape, the availability of nutrients, superinfection or exposure of infected cells to UV or various chemical stimuli. [PMID:19416825, PMID:24339346, VZ:3964]"}
{"concept_id": "C4328940", "aliases": [], "types": ["T026"], "canonical_name": "parallel fiber to Purkinje cell synapse", "definition": "An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. [PMID:16623829, PMID:3209740]"}
{"concept_id": "C4328941", "aliases": [], "types": ["T030"], "canonical_name": "hippocampal mossy fiber to CA3 synapse", "definition": "One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762]"}
{"concept_id": "C4328942", "aliases": [], "types": ["T030"], "canonical_name": "Schaffer collateral - CA1 synapse", "definition": "A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. [PMID:16399689]"}
{"concept_id": "C4328943", "aliases": [], "types": ["T030"], "canonical_name": "photoreceptor ribbon synapse", "definition": "A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. [PMID:15626493]"}
{"concept_id": "C4328944", "aliases": [], "types": ["T030"], "canonical_name": "cochlear hair cell ribbon synapse", "definition": "A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density. [PMID:15626493]"}
{"concept_id": "C4328945", "aliases": [], "types": ["T026"], "canonical_name": "arciform density", "definition": "An electron dense structure that anchors a synaptic ribbon to the presynaptic membrane. [PMID:15626493]"}
{"concept_id": "C4328946", "aliases": [], "types": ["T044"], "canonical_name": "template-free RNA nucleotidyltransferase", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition of a terminal nucleotide to an RNA molecule in the absence of a nucleic acid template. [GOC:BHF, GOC:BHF_telomere, GOC:dos, GOC:nc, PMID:15994230]"}
{"concept_id": "C4328948", "aliases": [], "types": ["T043"], "canonical_name": "viral tropism switching", "definition": "A process by which the range of hosts which a virus can bind and infect is changed. Examples include phages that switch between types of fibers via the action of a virally encoded invertase. [PMID:6232613, VZ:4498]"}
{"concept_id": "C4328949", "aliases": [], "types": ["T043"], "canonical_name": "modulation of host virulence by virus", "definition": "Any process by which a virus modulates the ability of its host to infect and/or damage an organism for which it is a host. Typically this involves a phage modulating the virulence of a bacterium. Mechanisms include the expression of factors that modulate a bacterial adhesion to a host cell, spread through host tissues, production exotoxins or provide protection against host immune defenses. [PMID:10913072, PMID:11553559, PMID:23981100, VZ:3965]"}
{"concept_id": "C4328950", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of neuronal dense core vesicle membrane", "definition": "The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]"}
{"concept_id": "C4328951", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of host DNA replication by virus", "definition": "Any process by which a virus inhibits DNA replication in its host cell. Some bacteriophages are known to do this, possibly as a way of increasing the pool of nucleotides available for virus replication. [PMID:17010157, PMID:21205014]"}
{"concept_id": "C4328952", "aliases": ["CRISPR-cas system evasion by virus", "evasion by virus of CRISPR-cas system"], "types": ["T043"], "canonical_name": "inhibition of host CRISPR-cas system by virus", "definition": "A process by which a virus inhibits the CRISPR-cas system of its host. [PMID:23242138, PMID:23446421, PMID:26416740]"}
{"concept_id": "C4328953", "aliases": ["viral attachment to host adhesion receptor"], "types": ["T043"], "canonical_name": "adhesion receptor-mediated virion attachment to host cell", "definition": "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that does not mediate or trigger entry into the host cell. This binding is typically reversible and enhances significantly infectivity by concentrating the virus in the vicinity of its entry receptors, or bringing it to an organ in which its target cells are located. [PMID:18351291, VZ:3943]"}
{"concept_id": "C4328954", "aliases": ["viral attachment to host entry receptor"], "types": ["T043"], "canonical_name": "entry receptor-mediated virion attachment to host cell", "definition": "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that mediates/triggers viral entry by endocytosis/pinocytosis or by inducing fusion/penetration. [PMID:18351291, VZ:3942]"}
{"concept_id": "C4328955", "aliases": [], "types": ["T040"], "canonical_name": "superinfection exclusion", "definition": "The process by which a preexisting viral infection prevents a secondary infection with the same or a closely related virus. Typically some aspect of viral entry is inhibited, but post entry mechanisms have also been documented. [PMID:11985726, PMID:23692331, PMID:24089557, PMID:8012757, VZ:3971]"}
{"concept_id": "C4328958", "aliases": ["G-protein coupled serotonin receptor signaling pathway"], "types": ["T043"], "canonical_name": "G protein-coupled serotonin receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands. [GOC:mah]"}
{"concept_id": "C4328959", "aliases": ["de novo centriole assembly via deuterosome"], "types": ["T043"], "canonical_name": "de novo centriole assembly involved in multi-ciliated epithelial cell differentiation", "definition": "Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation. [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997]"}
{"concept_id": "C4328962", "aliases": [], "types": ["T043"], "canonical_name": "clathrin-mediated membrane bending", "definition": "A membrane bending process mediated by clathrin. [GOC:pr, Wikipedia:Membrane_curvature]"}
{"concept_id": "C4328963", "aliases": [], "types": ["T043"], "canonical_name": "membrane bending", "definition": "A membrane organization process resulting in the bending of a membrane. [GOC:krc, GOC:pr, GOC:vw, Wikipedia:Membrane_curvature]"}
{"concept_id": "C4328964", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA stability", "definition": "Any process that modulates the stability of DNA. [GOC:pr]"}
{"concept_id": "C4328965", "aliases": ["sporophore formation"], "types": ["T039"], "canonical_name": "spore-bearing structure formation", "definition": "The process of generating a spore-bearing structure. A spore-bearing structure is an anatomical structure that produces new spores. [GOC:di]"}
{"concept_id": "C4328966", "aliases": ["endosomal membrane tubulation"], "types": ["T043"], "canonical_name": "endosome membrane tubulation", "definition": "A membrane tubulation process occurring in an endosome membrane. [GOC:bc, GOC:PARL, PMID:26911690]"}
{"concept_id": "C4328967", "aliases": [], "types": ["T044"], "canonical_name": "3'-5' RNA polymerase activity", "definition": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end. [GOC:pf, PMID:22456265, PMID:27484477]"}
{"concept_id": "C4328968", "aliases": ["blood vessel diameter homeostasis", "regulation of blood vessel diameter"], "types": ["T042"], "canonical_name": "blood vessel diameter maintenance", "definition": "Any process that modulates the diameter of blood vessels. [GOC:pr]"}
{"concept_id": "C4328969", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial tRNA 5'-end processing", "definition": "The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion. [GOC:pf, PMID:21307182, PMID:26143376, PMID:27484477]"}
{"concept_id": "C4328970", "aliases": [], "types": ["T039"], "canonical_name": "urate salt excretion"}
{"concept_id": "C4328971", "aliases": [], "types": ["T043"], "canonical_name": "de novo centriole assembly via blepharoplast", "definition": "A de novo centriole assembly process observed in multi-ciliated sperm cells of some primitive land plants, and where centrioles are formed from a blepharoplast, ultimately giving rise to multiple cilia on the sperm surface. [GOC:cilia, PMID:25047614]"}
{"concept_id": "C4328972", "aliases": [], "types": ["T026"], "canonical_name": "mastigoneme", "definition": "A hair-like structure covering the flagella found in some algae (heterokonts and cryptophytes). It is approximately 15 nm in diameter, and usually consist of a tubular shaft that itself terminates in smaller hairs. It is composed of glycoproteins and, likely, carbohydrates. Mastigonemes may assist in locomotion by increasing the surface area of a flagellum. [GOC:cilia, PMID:943397, Wikipedia:Mastigoneme]"}
{"concept_id": "C4328973", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ferrichrome biosynthetic process in response to iron", "definition": "Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus. [GOC:al]"}
{"concept_id": "C4328974", "aliases": [], "types": ["T040"], "canonical_name": "substrate mycelium formation", "definition": "The process by which, in some fungal species, hyphae grow as a network of invasive thread-like filaments formed from chains of attached cells within a solid or semi-solid substrate. [GOC:di, PMID:10021365]"}
{"concept_id": "C4328975", "aliases": [], "types": ["T040"], "canonical_name": "acquisition of mycelium reproductive competence", "definition": "A maturation process by which an organism acquires the ability to reproduce. In fungi, reproductive competence only occurs in a population of filamentous cells that form a mycelium. [GOC:di, PMID:23864594]"}
{"concept_id": "C4328976", "aliases": [], "types": ["T026"], "canonical_name": "DIM/DIP cell wall layer", "definition": "A section of the Actinobacterium-type cell wall composed of (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate, diphthioceranate and other compounds. [GOC:pr]"}
{"concept_id": "C4328977", "aliases": ["exosome biogenesis", "exosome assembly or secretion", "exosome production"], "types": ["T043"], "canonical_name": "extracellular exosome biogenesis", "definition": "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495]"}
{"concept_id": "C4328978", "aliases": ["non-motile 9+0 cilium", "9+0 immotile cilium"], "types": ["T026"], "canonical_name": "9+0 non-motile cilium", "definition": "A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). [GOC:cilia, PMID:22118931]"}
{"concept_id": "C4328979", "aliases": ["nonmotile cilium", "immotile cilium"], "types": ["T026"], "canonical_name": "non-motile cilium", "definition": "A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]"}
{"concept_id": "C4328980", "aliases": ["motile 9+2 cilium"], "types": ["T026"], "canonical_name": "9+2 motile cilium", "definition": "A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme). [GOC:cilia, PMID:22118931]"}
{"concept_id": "C4328981", "aliases": ["motile 9+0 cilium"], "types": ["T026"], "canonical_name": "9+0 motile cilium", "definition": "A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). [GOC:cilia, PMID:10330409, PMID:22118931]"}
{"concept_id": "C4328982", "aliases": ["LAP2, emerin, MAN1 domain binding", "lamina-associated polypeptide, emerin, MAN1 domain binding"], "types": ["T044"], "canonical_name": "LEM domain binding", "definition": "Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF). [GOC:rz, InterPro:IPR003887, PMID:22399800]"}
{"concept_id": "C4328983", "aliases": ["histone lysine H3 K79 dimethylation", "histone H3 K79 dimethylation"], "types": ["T044"], "canonical_name": "histone H3-K79 dimethylation", "definition": "The modification of histone H3 by addition of two methyl groups to lysine at position 79 of the histone. [GOC:hbye, PMID:27541139]"}
{"concept_id": "C4328985", "aliases": ["amoeboid sperm movement", "ameboid sperm motility", "ameboid sperm movement"], "types": ["T043"], "canonical_name": "amoeboid sperm motility", "definition": "Any process involved in the controlled movement of an amoeboid sperm cell. [GOC:cilia, GOC:krc]"}
{"concept_id": "C4328986", "aliases": ["calcineurin-mediated signalling"], "types": ["T043"], "canonical_name": "calcineurin-mediated signaling", "definition": "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544]"}
{"concept_id": "C4328987", "aliases": [], "types": ["T044"], "canonical_name": "disordered domain specific binding", "definition": "Binding to a disordered domain of a protein. [GOC:gg, PMID:11746698]"}
{"concept_id": "C4328988", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to viscosity", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus. [GOC:sl, PMID:7061416]"}
{"concept_id": "C4328989", "aliases": [], "types": ["T040"], "canonical_name": "response to viscosity", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus. [GOC:sl, PMID:7061416]"}
{"concept_id": "C4328990", "aliases": [], "types": ["T044"], "canonical_name": "dolichol-phosphate-mannose synthase regulator activity", "definition": "Binds to and modulates the activity of dolichol-phosphate-mannose synthase. [GOC:vw, PMID:10835346]"}
{"concept_id": "C4328991", "aliases": [], "types": ["T043"], "canonical_name": "vesicle targeting, trans-Golgi to periciliary membrane compartment", "definition": "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645, Reactome:R-HSA-5620920.1]"}
{"concept_id": "C4328992", "aliases": ["ciliary basal body docking"], "types": ["T043"], "canonical_name": "ciliary basal body-plasma membrane docking", "definition": "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235, Reactome:R-HSA-5620912.1]"}
{"concept_id": "C4328993", "aliases": [], "types": ["T039"], "canonical_name": "connective tissue replacement", "definition": "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:25590961]"}
{"concept_id": "C4328994", "aliases": [], "types": ["T043"], "canonical_name": "receptor localization to non-motile cilium", "definition": "A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium. [GOC:cilia, GOC:kmv, PMID:23128241]"}
{"concept_id": "C4328995", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to non-motile cilium", "definition": "A process in which a protein is transported to, or maintained in, a location within a non-motile cilium. [GOC:cilia, GOC:kmv, PMID:23128241]"}
{"concept_id": "C4328996", "aliases": [], "types": ["T043"], "canonical_name": "supramolecular fiber organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. [GOC:pr]"}
{"concept_id": "C4328997", "aliases": [], "types": ["T045"], "canonical_name": "telomere maintenance via telomere trimming", "definition": "A process that contributes to the maintenance of proper telomeric length and structure via the activation of telomere shortening pathways that compensate telomerase-dependent excessive telomere elongation. Telomere attrition is mediated by a mechanism which involves the generation of single-stranded C-rich telomeric DNA, and the formation and removal of double-stranded telomeric circular DNA (T-circles). Telomere trimming is an independent pathway to recombination-mediated telomere elongation and the well-documented gradual telomere attrition that accompanies cellular replication. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:27918544]"}
{"concept_id": "C4328998", "aliases": [], "types": ["T044"], "canonical_name": "MATH domain binding", "definition": "Binding to a meprin and TRAF homology (MATH) domain. [InterPro:IPR002083, PMID:22621901]"}
{"concept_id": "C4328999", "aliases": [], "types": ["T044"], "canonical_name": "DNA repair complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a DNA repair complex. [GOC:pg, PMID:27113759, PMID:27233470]"}
{"concept_id": "C4329000", "aliases": [], "types": ["T026"], "canonical_name": "site of DNA damage", "definition": "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:pg]"}
{"concept_id": "C4329001", "aliases": [], "types": ["T026"], "canonical_name": "cofilin-actin rod", "definition": "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and disulfide cross-linked cofilin multimers. [GOC:sl, PMID:22573689, PMID:24760020]"}
{"concept_id": "C4329002", "aliases": ["cellular response to VLDL particle stimulus"], "types": ["T043"], "canonical_name": "cellular response to very-low-density lipoprotein particle stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very-low-density lipoprotein particle stimulus. [GOC:aruk, GOC:bc]"}
{"concept_id": "C4329003", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of brood size", "definition": "Any process that decreases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time. [GOC:rz]"}
{"concept_id": "C4329004", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of brood size", "definition": "Any process that increases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time. [GOC:rz]"}
{"concept_id": "C4329005", "aliases": ["dynamic polarity patch at the cell cortex"], "types": ["T026"], "canonical_name": "cortical dynamic polarity patch", "definition": "A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation. [GOC:mah, PMID:23200991]"}
{"concept_id": "C4329006", "aliases": [], "types": ["T026"], "canonical_name": "peripheral region of growth cone", "definition": "The non-central region or periphery of the migrating motile tip of a growing nerve cell axon or dendrite. [GOC:sl, PMID:16260607]"}
{"concept_id": "C4329007", "aliases": [], "types": ["T026"], "canonical_name": "central region of growth cone", "definition": "The center of the migrating motile tip of a growing nerve cell axon or dendrite. [GOC:sl, PMID:16260607]"}
{"concept_id": "C4329009", "aliases": ["hetero-receptor complex formation"], "types": ["T044"], "canonical_name": "receptor-receptor interaction", "definition": "The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function. [GOC:dox, GOC:pad, GOC:PARL, PMID:22035699, PMID:24157794]"}
{"concept_id": "C4329010", "aliases": [], "types": ["T043"], "canonical_name": "primary adaptive immune response involving T cells and B cells", "definition": "An adaptive immune response mediated by naive T or B cells against an antigen not previously encountered by immune system. [GOC:add, PMID:26831526]"}
{"concept_id": "C4329011", "aliases": [], "types": ["T040"], "canonical_name": "primary adaptive immune response", "definition": "An adaptive immune response against an antigen not previously encountered by immune system. [GOC:add, PMID:26831526]"}
{"concept_id": "C4329012", "aliases": [], "types": ["T043"], "canonical_name": "adaptive immune effector response involving T cells and B lineage cells", "definition": "An adaptive immune effector response involving T cells and B lineage cells. In the case of B lineage cells, the effector cells are the antibody secreting plasma cells whereas for T cells the effector cells may be helper T cells or cytotoxic T cells. [GOC:add, ISBN:1405196831]"}
{"concept_id": "C4329013", "aliases": [], "types": ["T040"], "canonical_name": "adaptive immune effector response", "definition": "An adaptive immune response that involves one or more immune effector processes and takes place during the effector phase of the adaptive immune response. [GOC:add, ISBN:1405196831]"}
{"concept_id": "C4329014", "aliases": [], "types": ["T043"], "canonical_name": "adaptive immune memory response involving T cells and B cells", "definition": "An immune response mediated by reactivated memory T cells and B cells and directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response. [GOC:add, PMID:26831526]"}
{"concept_id": "C4329015", "aliases": [], "types": ["T040"], "canonical_name": "adaptive immune memory response", "definition": "An immune response directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response. [GOC:add, PMID:26831526]"}
{"concept_id": "C4329016", "aliases": [], "types": ["T042"], "canonical_name": "immunological memory formation process", "definition": "Any immunological memory process that can contribute to the formation of immunological memory. [GOC:add, PMID:26086132, PMID:26831526]"}
{"concept_id": "C4329017", "aliases": [], "types": ["T032"], "canonical_name": "innate immunity memory response", "definition": "An immune response mediated by the innate immune system and directed against a previously encountered immunologic stimulus, being quicker and quantitatively better compared with the initial response to that stimulus. [GOC:add, PMID:26086132]"}
{"concept_id": "C4329018", "aliases": [], "types": ["T042"], "canonical_name": "immunological memory process", "definition": "Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory. [GOC:add, PMID:26086132, PMID:26831526]"}
{"concept_id": "C4329019", "aliases": [], "types": ["T026"], "canonical_name": "basal pole of outer hair cell", "definition": "The end of the outer hair cell which receives and transmits neural signals. [GOC:sl, PMID:12845523]"}
{"concept_id": "C4329020", "aliases": [], "types": ["T044"], "canonical_name": "FMN hydrolase activity", "definition": "Catalysis of the reaction: FMN + H2O = riboflavin + phosphate. [EC:3.1.3.102, PMID:16183635]"}
{"concept_id": "C4329021", "aliases": [], "types": ["T044"], "canonical_name": "phosphomevalonate decarboxylase activity", "definition": "Catalysis of the reaction: ATP + (R)-mevalonate 5-phosphate = ADP + isopentenyl phosphate + CO2 + phosphate. [EC:4.1.1.99, MetaCyc:RXN-10067, PMID:24375100]"}
{"concept_id": "C4329022", "aliases": [], "types": ["T042"], "canonical_name": "regulation of timing of plant organ formation", "definition": "Any process that modulates the rate, frequency or extent of plant organ formation at a consistent predetermined time point during development. [GOC:tb]"}
{"concept_id": "C4329023", "aliases": [], "types": ["T042"], "canonical_name": "specification of plant organ axis polarity", "definition": "The process in which the polarity of a plant organ axis is specified. [GOC:tb]"}
{"concept_id": "C4329024", "aliases": [], "types": ["T042"], "canonical_name": "establishment of plant organ orientation", "definition": "The process that determines the orientation of a plant organ or tissue with reference to an axis. [GOC:tb]"}
{"concept_id": "C4329025", "aliases": [], "types": ["T042"], "canonical_name": "specification of plant organ position", "definition": "The regionalization process in which information that determines the correct position at which plant organ primordia are formed is generated and perceived resulting in correct positioning of the new plant organ. [GOC:tb, PMID:9611175]"}
{"concept_id": "C4329026", "aliases": [], "types": ["T026"], "canonical_name": "trichome papilla", "definition": "A plant cell papilla that is part of a trichome cell. [GOC:tb, PMID:24014871]"}
{"concept_id": "C4329027", "aliases": [], "types": ["T044"], "canonical_name": "nicotinate-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP. [GOC:tb, PMID:26116607]"}
{"concept_id": "C4329029", "aliases": [], "types": ["T042"], "canonical_name": "specification of plant organ identity", "definition": "The regionalization process in which the identity of a plant organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tb]"}
{"concept_id": "C4329030", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of plant organ identity", "definition": "The process in which the identity of a plant organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tb, PMID:9090883]"}
{"concept_id": "C4329032", "aliases": [], "types": ["T040"], "canonical_name": "post-embryonic plant morphogenesis", "definition": "The process, occurring after plant embryonic development, by which anatomical structures are generated and organized. [GOC:tb]"}
{"concept_id": "C4329033", "aliases": [], "types": ["T042"], "canonical_name": "post-embryonic plant organ morphogenesis", "definition": "Morphogenesis, during the post-embryonic phase, of a plant tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:tb]"}
{"concept_id": "C4329034", "aliases": [], "types": ["T042"], "canonical_name": "post-embryonic plant organ development", "definition": "Development, taking place during the post-embryonic phase of a plant tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:tb]"}
{"concept_id": "C4329035", "aliases": [], "types": ["T042"], "canonical_name": "plant organ senescence", "definition": "A plant organ developmental process during which a plant dismantles cellular components to reclaim the cellular building blocks and nutrients that have been deposited in the plant organs during growth. [GOC:tb, PMID:17177638, PMID:34938309]"}
{"concept_id": "C4329036", "aliases": [], "types": ["T026"], "canonical_name": "mitochondrial membrane scission site", "definition": "The site on the mitochondrial membrane where the separation of a single continuous mitochondrial membrane into two membranes occurs as a final step in mitochondrial fission. [GOC:bc, GOC:PARL, PMID:26618722]"}
{"concept_id": "C4329037", "aliases": [], "types": ["T042"], "canonical_name": "formation of plant organ boundary", "definition": "The regionalization process that specifies plant organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. [GOC:tb]"}
{"concept_id": "C4329038", "aliases": [], "types": ["T026"], "canonical_name": "cleavage furrow leading edge", "definition": "The 'trough' of the cleavage furrow. This is the part of the cleavage furrow closest to the contractile ring. [GOC:vw, PMID:27082518]"}
{"concept_id": "C4329039", "aliases": [], "types": ["T026"], "canonical_name": "cleavage furrow rim", "definition": "The part of the cleavage furrow closest to the cell surface. [GOC:vw, PMID:27082518]"}
{"concept_id": "C4329040", "aliases": [], "types": ["T044"], "canonical_name": "glycine betaine-activated nonselective monovalent cation channel activity", "definition": "Enables the transmembrane transfer of a monovalent cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts. [GOC:kmv, PMID:24212673]"}
{"concept_id": "C4329041", "aliases": ["RNA localisation to nucleus"], "types": ["T043"], "canonical_name": "RNA localization to nucleus", "definition": "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. [GOC:mah, PMID:26305931]"}
{"concept_id": "C4329042", "aliases": ["contact chemosensation receptor activity"], "types": ["T044"], "canonical_name": "contact chemoreceptor activity", "definition": "A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception. [GOC:hat, GOC:tb]"}
{"concept_id": "C4329043", "aliases": ["G-protein coupled receptor sweet taste receptor activity"], "types": ["T044"], "canonical_name": "GPCR sweet taste receptor activity", "definition": "A G protein-coupled receptor activity that is responsible for the sense of sweet taste. [GOC:hat, GOC:tb]"}
{"concept_id": "C4329044", "aliases": ["G-protein coupled receptor bitter taste receptor activity", "G protein-coupled receptor bitter taste receptor activity"], "types": ["T044"], "canonical_name": "GPCR bitter taste receptor activity", "definition": "A G protein-coupled receptor activity that is responsible for the sense of bitter taste. [GOC:hat, GOC:tb]"}
{"concept_id": "C4329045", "aliases": ["G-protein-coupled taste receptor activity", "G-protein coupled taste receptor activity"], "types": ["T044"], "canonical_name": "GPCR taste receptor activity", "definition": "A G protein-coupled receptor activity that is responsible for the sense of taste. [GOC:hat, GOC:tb]"}
{"concept_id": "C4329046", "aliases": [], "types": ["T043"], "canonical_name": "disruption by virus of host outer membrane", "definition": "A process by which a virus has a negative effect on the functioning of a host outer membrane. [PMID:17900620]"}
{"concept_id": "C4329047", "aliases": [], "types": ["T043"], "canonical_name": "cell differentiation involved in phenotypic switching", "definition": "A cell differentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. [GOC:curators]"}
{"concept_id": "C4329048", "aliases": [], "types": ["T043"], "canonical_name": "cell dedifferentiation involved in phenotypic switching", "definition": "A cell dedifferentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. [GOC:curators]"}
{"concept_id": "C4329049", "aliases": [], "types": ["T043"], "canonical_name": "reversible differentiation", "definition": "A phenotypic switching process where a cell reversibly differentiates and dedifferentiates from one cell type into another. [GOC:curators]"}
{"concept_id": "C4329050", "aliases": [], "types": ["T043"], "canonical_name": "receptor-mediated endocytosis involved in cholesterol transport", "definition": "A receptor-mediated endocytosis process involved in intracellular cholesterol transport. [GOC:ascb_2009, GOC:dph, GOC:pr, GOC:tb]"}
{"concept_id": "C4329051", "aliases": [], "types": ["T045"], "canonical_name": "5-carbamoylmethyl uridine residue modification", "definition": "The chemical reactions and pathways involving the addition of a 5-carbamoylmethyl group to a uridine residue in RNA. [GOC:dph, GOC:tb]"}
{"concept_id": "C4329052", "aliases": ["telosome assembly"], "types": ["T044"], "canonical_name": "shelterin complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a shelterin complex. A shelterin complex is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. [GOC:mah, GOC:vw]"}
{"concept_id": "C4329053", "aliases": [], "types": ["T043"], "canonical_name": "establishment of mitotic spindle asymmetry", "definition": "The mitotic spindle organization process by which a mitotic spindle becomes asymmetric either in position or structure. [PMID:26659188]"}
{"concept_id": "C4329054", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of histone H3-S10 phosphorylation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to histone H3 on a serine residue at position 10. [PMID:27521428]"}
{"concept_id": "C4329055", "aliases": [], "types": ["T043"], "canonical_name": "polarized secretion of basement membrane proteins in epithelium", "definition": "The basement membrane constituent secretion in which there is a restriction or targeting of basement membrane proteins for controlled release on the basal side of polarized epithelium. [PMID:26610918, PMID:28228250]"}
{"concept_id": "C4329056", "aliases": [], "types": ["T043"], "canonical_name": "basement membrane constituent secretion", "definition": "The controlled release of molecules that form the basement membrane, including carbohydrates and glycoproteins by a cell. [PMID:26610918, PMID:28228250]"}
{"concept_id": "C4329057", "aliases": [], "types": ["T044"], "canonical_name": "microtubule plus end polymerase", "definition": "Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers. [PMID:27872152]"}
{"concept_id": "C4329058", "aliases": ["cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one"], "types": ["T043"], "canonical_name": "cellular response to differentiation-inducing factor 2", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus. [PMID:19684855]"}
{"concept_id": "C4329059", "aliases": [], "types": ["T045"], "canonical_name": "DNA clamp unloader activity", "definition": "Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis. [GOC:vw, PMID:23499004]"}
{"concept_id": "C4329060", "aliases": ["ER pQC", "ER stress-indiced pre-emptive quality control"], "types": ["T043"], "canonical_name": "endoplasmic reticulum stress-induced pre-emptive quality control", "definition": "The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome. [PMID:17129784, PMID:26565908]"}
{"concept_id": "C4329061", "aliases": [], "types": ["T043"], "canonical_name": "Golgi calcium ion transmembrane transport", "definition": "A process in which a calcium ion is transported from one side of a Golgi membrane to the other by means of some agent such as a transporter or pore. [PMID:21811607]"}
{"concept_id": "C4329062", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of neuroblast migration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration. [PMID:23149556]"}
{"concept_id": "C4329063", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of neuroblast migration", "definition": "Any process that activates or increases the frequency, rate or extent of neuroblast migration. [PMID:23149556]"}
{"concept_id": "C4329064", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neuroblast migration", "definition": "Any process that modulates the frequency, rate or extent of neuroblast migration. [PMID:23149556]"}
{"concept_id": "C4329065", "aliases": [], "types": ["T026"], "canonical_name": "growth cone leading edge", "definition": "That part of the growth cone which represents the distal part of the structure. [PMID:10797548]"}
{"concept_id": "C4329066", "aliases": [], "types": ["T045"], "canonical_name": "telomeric G-quadruplex DNA binding", "definition": "Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:16142245, PMID:9512530]"}
{"concept_id": "C4329067", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to cholecystokinin", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus. [PMID:14622258]"}
{"concept_id": "C4329068", "aliases": [], "types": ["T043"], "canonical_name": "response to cholecystokinin", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus. [PMID:14622258]"}
{"concept_id": "C4329069", "aliases": [], "types": ["T026"], "canonical_name": "dendritic spine cytoplasm", "definition": "The region of the neuronal cytoplasm located in dendritic spines. [PMID:15673667]"}
{"concept_id": "C4329070", "aliases": [], "types": ["T026"], "canonical_name": "neuron projection branch point", "definition": "The location where a secondary projection arises from a neuron projection. [PMID:25586189]"}
{"concept_id": "C4329071", "aliases": ["antimicrobial peptide-mediated antimicrobial humoral response"], "types": ["T043"], "canonical_name": "antimicrobial humoral immune response mediated by antimicrobial peptide", "definition": "An immune response against microbes mediated by anti-microbial peptides in body fluid. [PMID:15761415, PMID:24287494]"}
{"concept_id": "C4329072", "aliases": ["restructuring of SCB", "SCB remodeling", "Sertoli cell barrier restructuring"], "types": ["T042"], "canonical_name": "Sertoli cell barrier remodeling", "definition": "The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle. [PMID:20534520, PMID:24467744]"}
{"concept_id": "C4329073", "aliases": ["MTOC localization"], "types": ["T043"], "canonical_name": "microtubule organizing center localization", "definition": "Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell. [PMID:21281821]"}
{"concept_id": "C4329074", "aliases": ["high-affinity ferrous iron uptake transmembrane transporter activity", "high affinity ferrous uptake transmembrane transporter activity"], "types": ["T044"], "canonical_name": "high-affinity ferrous iron transmembrane transporter activity", "definition": "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:bhm, PMID:9413439]"}
{"concept_id": "C4329075", "aliases": ["high-affinity ferrous ion transmembrane transport"], "types": ["T044"], "canonical_name": "high affinity ferrous ion transmembrane transport"}
{"concept_id": "C4329076", "aliases": [], "types": ["T044"], "canonical_name": "neuropeptide processing", "definition": "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide. [PMID:12657671, PMID:17564681]"}
{"concept_id": "C4329077", "aliases": [], "types": ["T026"], "canonical_name": "ventral surface of cell", "definition": "The surface of a migrating cell that is in contact with the substratum or cell layer. [PMID:11598004]"}
{"concept_id": "C4329078", "aliases": ["microfilament branch point"], "types": ["T026"], "canonical_name": "actin filament branch point", "definition": "The part of an actin filament where the structure forks. [PMID:18256280]"}
{"concept_id": "C4329079", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to tricellular tight junction", "definition": "A process in which a protein is transported to, or maintained in, a location within a tricellular tight junction. [PMID:24889144]"}
{"concept_id": "C4329080", "aliases": ["basal ES"], "types": ["T026"], "canonical_name": "basal ectoplasmic specialization", "definition": "Testis-specific junction between mature Sertoli cells involved in establishing the blood-testis barrier of the Sertoli cell. [GOC:aruk, GOC:bc, GOC:dph, PMID:22332112, PMID:23546604]"}
{"concept_id": "C4329081", "aliases": ["apical ES"], "types": ["T026"], "canonical_name": "apical ectoplasmic specialization", "definition": "Testis-specific junction between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell. [GOC:aruk, GOC:bc, GOC:dph, PMID:22332112, PMID:23546604]"}
{"concept_id": "C4329082", "aliases": [], "types": ["T026"], "canonical_name": "concave side of sperm head", "definition": "The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species. [PMID:22332112, PMID:23403943, PMID:26990065]"}
{"concept_id": "C4329083", "aliases": [], "types": ["T026"], "canonical_name": "podosome ring", "definition": "The ring structure surrounding the podosome core, containing proteins such as vinculin and talin. [PMID:23158496]"}
{"concept_id": "C4329084", "aliases": [], "types": ["T043"], "canonical_name": "cytosolic ciliogenesis", "definition": "The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm. [PMID:25447994, PMID:26654377]"}
{"concept_id": "C4329085", "aliases": [], "types": ["T026"], "canonical_name": "ring centriole", "definition": "A ring-like structure observed at the base of the ciliary cap of insect spermatids. This structure may anchor the axoneme to the ciliary cap membrane and/or act as a diffusion barrier, proposed to be analogous to the annulus of mammalian sperm flagellum. [PMID:25447994, PMID:4903810]"}
{"concept_id": "C4329086", "aliases": ["spermatid ciliary cap"], "types": ["T026"], "canonical_name": "ciliary cap", "definition": "An intracellular compartmentalized cilium structure found in insect spermatids which is bounded by a membrane derived from the invagination of the cell membrane that remains associated with the primary cilium as it is internalized. The ciliary cap is maintained at the end of the axoneme distal to the centriole and is separated from the cytosolic axoneme/cytoplasm by a putative transition zone, which may extend into the ciliary cap, and include a structure at the base of the ciliary cap termed the ring centriole. [PMID:25447994, PMID:27646273]"}
{"concept_id": "C4329087", "aliases": ["telomeric Displacement-loop binding"], "types": ["T045"], "canonical_name": "telomeric D-loop binding", "definition": "Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19734539]"}
{"concept_id": "C4329088", "aliases": [], "types": ["T045"], "canonical_name": "telomeric D-loop disassembly", "definition": "A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:10338204, PMID:24012755]"}
{"concept_id": "C4329089", "aliases": ["TDMs formation"], "types": ["T045"], "canonical_name": "telomeric DNA-containing double minutes formation", "definition": "A telomere maintenance process that results in the formation of small fragments of circular extrachromosomal DNA elements which contain telomeric DNA. It is speculated that telomeric DNA-containing double minutes are formed through a recombination event between the telomere and chromosome-internal TTAGGG-like sequences. Telomeric DNA-containing double minutes appear as two closely positioned dots in metaphase. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:14690602, PMID:2397458]"}
{"concept_id": "C4329090", "aliases": [], "types": ["T045"], "canonical_name": "tRNA folding", "definition": "The process of assisting in the folding of tRNAs into the correct tertiary structure. [GOC:dph, PMID:27849601]"}
{"concept_id": "C4329091", "aliases": ["ER-plasma membrane tethering"], "types": ["T043"], "canonical_name": "endoplasmic reticulum-plasma membrane tethering", "definition": "The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers. [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684]"}
{"concept_id": "C4329092", "aliases": [], "types": ["T043"], "definition": "The selective autophagy process that clears 26S proteasomes; homeostatic mechanism within the ubiquitin system that modulates proteolytic capacity and eliminates damaged particles. [GOC:dph, GOC:se, PMID:26670610, PMID:27477278]", "canonical_name": "proteaphagy"}
{"concept_id": "C4329093", "aliases": ["linear ubiquitin specific deubiquitinase activity", "Met1 linkage specific DUB", "deubiquitinase, acting on linear ubiquitin", "cysteine-type deubiquitinase activity, acting on linear ubiquitin", "ubiquitinyl hydrolase activity, acting on linear ubiquitin"], "types": ["T044"], "canonical_name": "Met1-linked polyubiquitin deubiquitinase activity", "definition": "Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains. [GOC:dph, PMID:26503766, PMID:27702987]"}
{"concept_id": "C4329094", "aliases": [], "types": ["T044"], "canonical_name": "NAD glycohydrolase activity", "definition": "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate. [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528]"}
{"concept_id": "C4329095", "aliases": [], "types": ["T044"], "canonical_name": "NAD+ nucleotidase, cyclic ADP-ribose generating", "definition": "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity. [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528]"}
{"concept_id": "C4329096", "aliases": ["positive regulation of centromeric recombination"], "types": ["T045"], "canonical_name": "positive regulation of DNA recombination at centromere", "definition": "Any process that activates or increases the frequency, rate or extent of DNA recombination at the centromere. [GOC:dph, GOC:mah]"}
{"concept_id": "C4329097", "aliases": ["mitotic anaphase spindle elongation", "mitotic spindle elongation during anaphase", "mitotic spindle elongation during mitotic anaphase"], "types": ["T043"], "canonical_name": "mitotic spindle elongation (spindle phase three)", "definition": "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B. [GOC:dph, GOC:vw, PMID:21920317]"}
{"concept_id": "C4329098", "aliases": ["mitotic spindle elongation during prophase and prometaphase", "mitotic spindle elongation during mitotic prophase", "mitotic spindle elongation during prophase"], "types": ["T043"], "canonical_name": "mitotic spindle formation (spindle phase one)", "definition": "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase. [GOC:dph, GOC:vw, PMID:21920317]"}
{"concept_id": "C4329099", "aliases": [], "types": ["T026"], "canonical_name": "posterior cell cortex", "definition": "The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis. [GOC:dph, GOC:kmv, PMID:15666355, PMID:17981131]"}
{"concept_id": "C4329100", "aliases": [], "types": ["T026"], "canonical_name": "anterior cell cortex", "definition": "The region that lies just beneath the plasma membrane in the part of a cell that is closest to the anterior as defined by the developing, or existing, anterior/posterior axis. [GOC:15666355, GOC:17981131, GOC:dph, GOC:kmv]"}
{"concept_id": "C4329101", "aliases": [], "types": ["T026"], "canonical_name": "fibronectin fibril", "definition": "A supramolecular fiber formed from fibronectin molecules. The fibrils are 5 to 25nm in diameter and can form branched meshworks. [GOC:dph, PMID:20690820]"}
{"concept_id": "C4329102", "aliases": [], "types": ["T044"], "canonical_name": "cyclic pyranopterin monophosphate synthase activity", "definition": "Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate. [GOC:dph, GOC:ik, PMID:25896388]"}
{"concept_id": "C4329103", "aliases": [], "types": ["T044"], "canonical_name": "GTP 3',8'-cyclase activity", "definition": "Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. [GOC:dph, GOC:ik, PMID:25896388]"}
{"concept_id": "C4329104", "aliases": [], "types": ["T044"], "canonical_name": "pH-gated chloride channel activity", "definition": "A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH. [GOC:dph, PMID:27358471]"}
{"concept_id": "C4329105", "aliases": [], "types": ["T043"], "canonical_name": "membrane addition at site of mitotic cytokinesis", "definition": "A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion. [GOC:dph, GOC:vw]"}
{"concept_id": "C4329106", "aliases": [], "types": ["T043"], "canonical_name": "Golgi lumen acidification", "definition": "Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion. [GOC:dph, PMID:23447592]"}
{"concept_id": "C4329107", "aliases": [], "types": ["T043"], "canonical_name": "secretory granule maturation", "definition": "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodelling. [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809]"}
{"concept_id": "C4329108", "aliases": [], "types": ["T044"], "canonical_name": "GTPase motor activity", "definition": "A motor activity driven by GTP hydrolysis. [GOC:dph, GOC:vw, PMID:11242086]"}
{"concept_id": "C4329109", "aliases": [], "types": ["T043"], "canonical_name": "dense core granule docking", "definition": "The initial attachment of a dense core granule membrane to the plasma membrane. [GOC:bf, GOC:PARL, PMID:26575293]"}
{"concept_id": "C4329110", "aliases": ["LDCV priming", "large dense-core vesicle priming", "dense core vesicle priming"], "types": ["T044"], "canonical_name": "dense core granule priming", "definition": "A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking. [GOC:bf, GOC:PARL, PMID:10899113, PMID:26575293]"}
{"concept_id": "C4329111", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan cross-bridge peptide endopeptidase activity", "definition": "A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge. [GOC:dph, GOC:jh, PMID:22748813]"}
{"concept_id": "C4329112", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan stem peptide endopeptidase activity", "definition": "A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan. [GOC:dph, GOC:jh, PMID:22748813]"}
{"concept_id": "C4329113", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan endopeptidase activity", "definition": "An endopeptidase activity that uses peptidoglycan as a substrate. [GOC:dph, GOC:jh, PMID:22748813]"}
{"concept_id": "C4329114", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan N-acetylglucosaminidase activity", "definition": "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan. [GOC:dph, GOC:jh, PMID:22748813]"}
{"concept_id": "C4329115", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan muralytic activity", "definition": "A catalytic activity that contributes to the degradation of peptidoglycan. [GOC:dph, GOC:jh, PMID:22748813]"}
{"concept_id": "C4329116", "aliases": ["vesicle-vesicle fusion", "vesicle to vesicle fusion"], "types": ["T043"], "canonical_name": "vesicle fusion with vesicle", "definition": "Fusion of the membrane of a transport vesicle with a target membrane on another vesicle. [GOC:bf, GOC:PARL, PMID:16618809]"}
{"concept_id": "C4329117", "aliases": [], "types": ["T045"], "canonical_name": "mitotic cohesin unloading", "definition": "Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA as part of the mitotic cell cycle. [GOC:dph, GOC:mah, GOC:vw]"}
{"concept_id": "C4329118", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cohesin loading", "definition": "The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle. [GOC:dph, GOC:vw]"}
{"concept_id": "C4329119", "aliases": [], "types": ["T044"], "canonical_name": "intracellular chloride channel activity", "definition": "Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:dph, PMID:23092411]"}
{"concept_id": "C4329121", "aliases": [], "types": ["T045"], "canonical_name": "topological DNA entrapment activity"}
{"concept_id": "C4329122", "aliases": ["cohesin loading ATPase", "cohesin ATPase activity", "ATP-dependent cohesin loading activity"], "types": ["T044"], "canonical_name": "cohesin loading activity", "definition": "Facilitating a conformational change to load a cohesin complex around sister chromatids, driven by ATP hydrolysis. [GOC:vw, PMID:26687354]"}
{"concept_id": "C4329123", "aliases": ["DNA exit from the cohesin ring"], "types": ["T045"], "canonical_name": "cohesin unloading", "definition": "Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA. [GOC:dph, GOC:vw, PMID:26687354]"}
{"concept_id": "C4329124", "aliases": ["drug transport across blood-nerve barrier", "drug transport across perineurial barrier"], "types": ["T043"], "canonical_name": "xenobiotic transport across blood-nerve barrier", "definition": "The directed movement of a xenobiotic through the blood-nerve barrier. [GOC:dph, PMID:22733753]"}
{"concept_id": "C4329125", "aliases": [], "types": ["T039"], "canonical_name": "response to caloric restriction", "definition": "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake. [GOC:dph, PMID:15520862]"}
{"concept_id": "C4329126", "aliases": [], "types": ["T044"], "canonical_name": "translation elongation factor binding", "definition": "Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation. [GOC:dph]"}
{"concept_id": "C4329127", "aliases": [], "types": ["T044"], "canonical_name": "ribosylnicotinate kinase activity", "definition": "Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H(+) + nicotinate mononucleotide. [GOC:dph, PMID:17914902]"}
{"concept_id": "C4329128", "aliases": [], "types": ["T044"], "canonical_name": "magnesium:sodium antiporter activity", "definition": "Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in). [GOC:pad, GOC:PARL, PMID:22031603]"}
{"concept_id": "C4329129", "aliases": [], "types": ["T042"], "canonical_name": "branching involved in lymph vessel morphogenesis", "definition": "The process of the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C4329130", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of flagellated sperm motility involved in capacitation", "definition": "The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence. [GOC:cilia, GOC:dph, GOC:krc]"}
{"concept_id": "C4329131", "aliases": ["cilium formation", "microtubule-based flagellum assembly", "ciliogenesis"], "types": ["T043"], "canonical_name": "cilium assembly", "definition": "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]"}
{"concept_id": "C4329132", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic vesicle lumen", "definition": "The volume enclosed by a cytoplasmic vesicle. [GOC:dph, GOC:vesicles]"}
{"concept_id": "C4329133", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of timing of exogen", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle. [GOC:ai, GOC:pr]"}
{"concept_id": "C4329134", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of timing of exogen", "definition": "Any process that activates or increases the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle. [GOC:ai, GOC:pr]"}
{"concept_id": "C4329135", "aliases": [], "types": ["T039"], "canonical_name": "regulation of timing of exogen", "definition": "Any process that modulates the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle. [GOC:ai, GOC:pr]"}
{"concept_id": "C4329136", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of timing of anagen", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle. [GOC:ai, GOC:pr]"}
{"concept_id": "C4329137", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of timing of anagen", "definition": "Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle. [GOC:ai, GOC:pr]"}
{"concept_id": "C4329138", "aliases": [], "types": ["T039"], "canonical_name": "regulation of timing of anagen", "definition": "Any process that modulates the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle. [GOC:ai, GOC:pr]"}
{"concept_id": "C4329139", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of timing of catagen", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle. [GOC:ai, GOC:pr]"}
{"concept_id": "C4329140", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of timing of catagen", "definition": "Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle. [GOC:ai, GOC:pr]"}
{"concept_id": "C4329141", "aliases": [], "types": ["T039"], "canonical_name": "regulation of timing of catagen", "definition": "Any process that modulates the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle. [GOC:ai, GOC:pr]"}
{"concept_id": "C4329142", "aliases": ["vasodilation in other organism"], "types": ["T038"], "canonical_name": "vasodilation in another organism", "definition": "A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism. [GOC:ecd, GOC:jl, PMID:21050868]"}
{"concept_id": "C4329143", "aliases": ["envenomation resulting in vasodilation in other organism"], "types": ["T038"], "canonical_name": "envenomation resulting in vasodilation in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism. [GOC:ecd, GOC:jl, PMID:21050868]"}
{"concept_id": "C4329144", "aliases": [], "types": ["T044"], "canonical_name": "glutathione deglycation", "definition": "The removal of a sugar or dicarbonyl from glycated glutathione. Glutathione is the tripeptide glutamylcysteinylglycine. [GOC:bf, GOC:PARL, PMID:25416785]"}
{"concept_id": "C4329145", "aliases": [], "types": ["T044"], "canonical_name": "protein deglycation, methylglyoxal removal", "definition": "The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein. [GOC:bf, GOC:PARL, PMID:25416785]"}
{"concept_id": "C4329146", "aliases": [], "types": ["T044"], "canonical_name": "protein deglycation, glyoxal removal", "definition": "The removal of glyoxal from a glycated protein, to form glycolate and a deglycated protein. [GOC:bf, GOC:PARL, PMID:25416785]"}
{"concept_id": "C4329147", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine deglycation", "definition": "The removal of a sugar or dicarbonyl from a lysine residue of a glycated protein. [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785]"}
{"concept_id": "C4329148", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-arginine deglycation", "definition": "The removal of a sugar or dicarbonyl from an arginine residue of a glycated protein. [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785]"}
{"concept_id": "C4329149", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-cysteine deglycation", "definition": "The removal of a sugar or dicarbonyl from a cysteine residue of a glycated protein. [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785]"}
{"concept_id": "C4329150", "aliases": [], "types": ["T044"], "canonical_name": "protein deglycation", "definition": "The removal of a sugar or dicarbonyl from a glycated protein. [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785]"}
{"concept_id": "C4329151", "aliases": [], "types": ["T044"], "canonical_name": "protein deglycase activity", "definition": "Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein. [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785, PMID:26873906]"}
{"concept_id": "C4329152", "aliases": ["disruption of host protein localisation to phagosome", "suppression of host protein localisation to phagosome", "inhibition of host protein localisation to phagosome"], "types": ["T043"], "canonical_name": "negative regulation by symbiont of host protein localization to phagocytic vesicle", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:bf, GOC:PARL, PMID:25063865]"}
{"concept_id": "C4329153", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host protein localization to phagocytic vesicle", "definition": "Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:bf, GOC:PARL, PMID:25063865]"}
{"concept_id": "C4329154", "aliases": [], "types": ["T043"], "canonical_name": "intraciliary transport involved in cilium assembly", "definition": "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. [GOC:bf, GOC:cilia, Reactome:R-HSA-5620924.2]"}
{"concept_id": "C4329156", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of plasma lipoprotein oxidation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma. [GOC:BHF, GOC:mah]"}
{"concept_id": "C4329157", "aliases": [], "types": ["T044"], "canonical_name": "regulation of plasma lipoprotein oxidation", "definition": "Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma. [GOC:BHF, GOC:mah]"}
{"concept_id": "C4329158", "aliases": [], "types": ["T044"], "canonical_name": "plasma lipoprotein oxidation"}
{"concept_id": "C4329159", "aliases": [], "types": ["T026"], "canonical_name": "triglyceride-rich plasma lipoprotein particle", "definition": "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood. [GOC:BHF, GOC:mah, GOC:rl]"}
{"concept_id": "C4329160", "aliases": ["ATPase-coupled thiosulfate transmembrane transporter activity", "thiosulphate ABC transporter activity"], "types": ["T044"], "canonical_name": "ABC-type thiosulfate transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in). [GOC:mlg, GOC:pz]"}
{"concept_id": "C4329161", "aliases": ["flagellated sperm movement", "sperm flagellum movement", "sperm flagellum movement involved in flagellated sperm motility", "sperm flagellum movement involved in flagellated sperm movement"], "types": ["T043"], "canonical_name": "flagellated sperm motility", "definition": "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]"}
{"concept_id": "C4329162", "aliases": ["serotonin-activated cation-selective channel activity"], "types": ["T044"], "canonical_name": "serotonin-gated cation-selective channel activity", "definition": "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C4329163", "aliases": ["establishment of localization by movement along microtubule", "movement along microtubule"], "types": ["T043"], "canonical_name": "transport along microtubule", "definition": "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. [GOC:dph, GOC:mah, GOC:tb]"}
{"concept_id": "C4329164", "aliases": [], "types": ["T043"], "canonical_name": "programmed cell death involved in cell development", "definition": "The activation of endogenous cellular processes that result in the death of a cell as part of its development. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]"}
{"concept_id": "C4329165", "aliases": [], "types": ["T040"], "canonical_name": "acquisition of plant reproductive competence", "definition": "The process in which a plant acquires the ability to respond to a floral inductive signal. [GOC:tair_curators]"}
{"concept_id": "C4329166", "aliases": [], "types": ["T043"], "canonical_name": "chemical synaptic transmission", "definition": "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]"}
{"concept_id": "C4329167", "aliases": [], "types": ["T043"], "canonical_name": "female meiotic nuclear division", "definition": "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. [GOC:dph, GOC:ems, GOC:mah, GOC:vw]"}
{"concept_id": "C4329168", "aliases": [], "types": ["T043"], "canonical_name": "male meiotic nuclear division", "definition": "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. [GOC:dph, GOC:mah, GOC:vw]"}
{"concept_id": "C4329169", "aliases": ["axonemal interdoublet link"], "types": ["T026"], "canonical_name": "axonemal nexin link", "definition": "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules. [GOC:cilia, GOC:krc, ISBN:0198506732, PMID:21586547, PMID:21728999, PMID:22683354, PMID:9295136]"}
{"concept_id": "C4329170", "aliases": [], "types": ["T042"], "canonical_name": "norepinephrine-mediated vasodilation", "definition": "A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings. [GOC:mtg_cardio]"}
{"concept_id": "C4329171", "aliases": [], "types": ["T042"], "canonical_name": "epinephrine-mediated vasodilation", "definition": "A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings. [GOC:mtg_cardio]"}
{"concept_id": "C4329172", "aliases": [], "types": ["T044"], "canonical_name": "5'-deoxynucleotidase activity", "definition": "Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate. [EC:3.1.3.89]"}
{"concept_id": "C4329173", "aliases": [], "types": ["T044"], "canonical_name": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity", "definition": "Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione. [EC:5.3.1.32]"}
{"concept_id": "C4329174", "aliases": [], "types": ["T044"], "canonical_name": "leukotriene-C(4) hydrolase", "definition": "Catalysis of the reaction leukotriene C(4) + H(2)O= leukotriene D(4) + L-glutamate. [PMID:9774450, RHEA:31563]"}
{"concept_id": "C4329175", "aliases": [], "types": ["T044"], "canonical_name": "ceramide phosphoethanolamine synthase activity", "definition": "Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine. [EC:2.7.8.n3, PMID:25667419]"}
{"concept_id": "C4329176", "aliases": ["regulation of blood vessel diameter by renin-angiotensin"], "types": ["T039"], "canonical_name": "maintenance of blood vessel diameter homeostasis by renin-angiotensin", "definition": "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system. [GOC:dph, GOC:pr, GOC:tb]"}
{"concept_id": "C4520955", "aliases": ["octadecanal alkane-lyase activity"], "types": ["T044"], "canonical_name": "octadecanal decarbonylase activity", "definition": "Catalysis of the reaction: octadecanal = heptadecane + CO. [EC:4.1.99.5, GOC:tb]"}
{"concept_id": "C4520956", "aliases": ["CO-dehydrogenase (ferredoxin) activity", "CODH", "carbon-monoxide dehydrogenase (ferredoxin) activity", "carbon monoxide dehydrogenase activity", "carbon-monoxide:(acceptor) oxidoreductase activity", "CO-dehydrogenase activity", "carbon-monoxide,water:ferredoxin oxidoreductase activity", "CO dehydrogenase activity", "carbon-monoxide dehydrogenase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin. [EC:1.2.7.4]", "canonical_name": "carbon monoxide dehydrogenase (ferredoxin) activity"}
{"concept_id": "C4521061", "aliases": ["3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity", "SCPchi", "PTE-2", "SCP-X"], "types": ["T044"], "definition": "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA. [EC:2.3.1.176]", "canonical_name": "propanoyl-CoA C-acyltransferase activity"}
{"concept_id": "C4551660", "aliases": [], "types": ["T070"], "canonical_name": "virus-host interaction"}
{"concept_id": "C4551783", "aliases": ["ER to Golgi transport vesicle", "endoplasmic reticulum to Golgi transport vesicle", "endoplasmic reticulum-Golgi transport vesicle"], "types": ["T026"], "canonical_name": "ER-Golgi transport vesicle", "definition": "OBSOLETE. (Was not defined before being made obsolete). [GOC:go_curators]"}
{"concept_id": "C4551806", "aliases": ["acylsphingosine deacylase activity"], "types": ["T044"], "canonical_name": "N-acylsphingosine amidohydrolase activity", "definition": "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. [EC:3.5.1.23]"}
{"concept_id": "C4551808", "aliases": ["intracellular transport of viral capsid protein in host cell"], "types": ["T043"], "canonical_name": "intracellular transport of viral capsid in host cell"}
{"concept_id": "C4551840", "aliases": ["D-alanyl-poly(phosphoglycerol) synthetase activity"], "types": ["T044"], "canonical_name": "D-alanine-poly(phosphoribitol) ligase activity"}
{"concept_id": "C4551907", "aliases": ["negative regulation of synaptic vesicle fusion to presynaptic membrane", "negative regulation of synaptic vesicle fusion to pre-synaptic membrane"], "types": ["T043"], "canonical_name": "negative regulation of synaptic vesicle fusion to presynaptic membrane"}
{"concept_id": "C4551946", "aliases": ["autophagosome fusion", "autophagic vacuole fusion"], "types": ["T043"], "canonical_name": "autophagosome fusion"}
{"concept_id": "C4552082", "aliases": ["inhibition of L-glutamine uptake", "negative regulation of L-glutamine uptake", "negative regulation of L-glutamine import"], "types": ["T044"], "canonical_name": "negative regulation of L-glutamine import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine import into a cell. [GOC:TermGenie]"}
{"concept_id": "C4552099", "aliases": ["upregulation of hexokinase type IV glucokinase activity", "up-regulation of hexokinase type IV", "upregulation of hexokinase type IV", "up regulation of hexokinase type IV", "upregulation of hexokinase type IV (glucokinase) activity", "up-regulation of hexokinase type IV (glucokinase) activity", "up regulation of hexokinase type IV glucokinase activity"], "types": ["T044"], "canonical_name": "up regulation of hexokinase type IV (glucokinase) activity"}
{"concept_id": "C4552102", "aliases": ["upregulation of cyclin-dependent protein kinase activity", "up regulation of cyclin-dependent protein kinase activity", "up-regulation of cyclin-dependent protein kinase activity"], "types": ["T043"], "canonical_name": "up regulation of cyclin-dependent protein kinase activity"}
{"concept_id": "C4553256", "aliases": ["tripartite attachment complex location", "tripartite attachment complex"], "types": ["T026"], "definition": "A three-part cytoskeletal structure in kinetoplastid species linking mitochondrial DNA organised in a kinetoplast through the mitochondrial membranes to the basal body. [PMID:12802053, PMID:18059470, PMID:24821793, PMID:27168148]", "canonical_name": "TAC"}
{"concept_id": "C4553421", "aliases": ["CIT"], "types": ["T040"], "definition": "The process by which heat is generated by increasing metabolism in response to cold ambient temperatures in order to maintain a stable core body temperature. [PMID:27876809]", "canonical_name": "cold-induced thermogenesis"}
{"concept_id": "C4555203", "aliases": ["DNA-(apurinic or apyrimidinic site) lyase activity", "AP site-DNA 5'-phosphomonoester-lyase activity", "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity", "class I DNA-(apurinic or apyrimidinic site) endonuclease activity"], "types": ["T045"], "definition": "Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. [PMID:1698278, RHEA:66592]", "canonical_name": "class I DNA-(apurinic or apyrimidinic site) lyase activity"}
{"concept_id": "C4555204", "aliases": [], "types": ["T044"], "canonical_name": "tRNA pseudouridine(38-40) synthase"}
{"concept_id": "C4555208", "aliases": [], "types": ["T044"], "definition": "A process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of the metabolism of other carbon sources. [PMID:29295552]", "canonical_name": "carbon catabolite repression"}
{"concept_id": "C4689646", "aliases": [], "types": ["T044"], "canonical_name": "Hog1/Sty1 stress-activated MAPK cascade"}
{"concept_id": "C4689647", "aliases": [], "types": ["T045"], "canonical_name": "2'-phosphotransferase activity"}
{"concept_id": "C4689648", "aliases": [], "types": ["T044"], "canonical_name": "multicellular organismal polysaccharide catabolic process"}
{"concept_id": "C4689649", "aliases": ["translation repressor activity, mRNA regulatory element binding"], "types": ["T045"], "canonical_name": "mRNA regulatory element binding translation repressor activity", "definition": "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid. [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370]"}
{"concept_id": "C4689650", "aliases": [], "types": ["T045"], "canonical_name": "core promoter proximal region DNA binding"}
{"concept_id": "C4689663", "aliases": [], "types": ["T045"], "canonical_name": "snoRNA transcription by RNA polymerase III", "definition": "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter. [GOC:txnOH]"}
{"concept_id": "C4689664", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial promoter sequence-specific DNA binding", "definition": "Binding to a DNA region that controls the transcription of the mitochondrial DNA. [GOC:txnOH, GOC:vw, PMID:20056105]"}
{"concept_id": "C4689665", "aliases": [], "types": ["T045"], "canonical_name": "HSP coding strand binding"}
{"concept_id": "C4689666", "aliases": [], "types": ["T045"], "canonical_name": "HSP non-coding strand binding"}
{"concept_id": "C4689667", "aliases": [], "types": ["T045"], "canonical_name": "HSPas binding"}
{"concept_id": "C4689668", "aliases": [], "types": ["T044"], "canonical_name": "HSPs binding"}
{"concept_id": "C4689669", "aliases": [], "types": ["T045"], "canonical_name": "LSP coding strand binding"}
{"concept_id": "C4689670", "aliases": [], "types": ["T044"], "canonical_name": "LSP non-coding strand binding"}
{"concept_id": "C4689671", "aliases": [], "types": ["T045"], "canonical_name": "LSPas binding"}
{"concept_id": "C4689672", "aliases": [], "types": ["T045"], "canonical_name": "LSPs binding"}
{"concept_id": "C4689673", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial heavy strand promoter anti-sense binding"}
{"concept_id": "C4689674", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial heavy strand promoter sense binding"}
{"concept_id": "C4689675", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial light strand promoter anti-sense binding"}
{"concept_id": "C4689676", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial light strand promoter sense binding"}
{"concept_id": "C4689677", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial proximal promoter sequence-specific DNA binding"}
{"concept_id": "C4689678", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding"}
{"concept_id": "C4689679", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial RNA polymerase core promoter sequence-specific DNA binding"}
{"concept_id": "C4689680", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial RNA polymerase regulatory region sequence-specific DNA binding"}
{"concept_id": "C4689681", "aliases": ["RNA binding transcription regulator activity"], "types": ["T045"], "canonical_name": "RNA-binding transcription regulator activity", "definition": "A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences. [GOC:txnOH-2018, PMID:1756726]"}
{"concept_id": "C4689682", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity"}
{"concept_id": "C4689683", "aliases": [], "types": ["T045"], "canonical_name": "transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting"}
{"concept_id": "C4689684", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript"}
{"concept_id": "C4689685", "aliases": [], "types": ["T044"], "canonical_name": "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript"}
{"concept_id": "C4689686", "aliases": [], "types": ["T044"], "canonical_name": "phosphotyrosine residue binding", "definition": "Binding to a phosphorylated tyrosine residue within a protein. [PMID:14636584]"}
{"concept_id": "C4689687", "aliases": [], "types": ["T040"], "canonical_name": "angiotensin catabolic process in blood"}
{"concept_id": "C4689688", "aliases": ["regulation of L-glutamate uptake"], "types": ["T043"], "canonical_name": "regulation of L-glutamate import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell. [GOC:TermGenie]"}
{"concept_id": "C4689689", "aliases": ["regulation of L-glutamate import"], "types": ["T044"], "canonical_name": "regulation of L-glutamate import"}
{"concept_id": "C4689690", "aliases": ["down-regulation of L-glutamate import", "downregulation of L-glutamate import", "down regulation of L-glutamate import"], "types": ["T044"], "canonical_name": "negative regulation of L-glutamate import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell. [GOC:TermGenie]"}
{"concept_id": "C4689691", "aliases": ["down-regulation of L-glutamate uptake", "down regulation of L-glutamate uptake"], "types": ["T044"], "canonical_name": "downregulation of L-glutamate uptake"}
{"concept_id": "C4689692", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-glutamate import"}
{"concept_id": "C4689693", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of L-glutamate uptake"}
{"concept_id": "C4689694", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of L-glutamate import"}
{"concept_id": "C4689695", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of L-glutamate uptake"}
{"concept_id": "C4689696", "aliases": ["positive regulation of L-glutamate transport"], "types": ["T044"], "canonical_name": "positive regulation of L-glutamate import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell. [GOC:TermGenie]"}
{"concept_id": "C4689697", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-glutamate import"}
{"concept_id": "C4689698", "aliases": [], "types": ["T044"], "canonical_name": "activation of L-glutamate uptake"}
{"concept_id": "C4689699", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of L-glutamate import"}
{"concept_id": "C4689700", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of L-glutamate uptake"}
{"concept_id": "C4689701", "aliases": ["up-regulation of L-glutamate uptake", "up regulation of L-glutamate uptake"], "types": ["T044"], "canonical_name": "upregulation of L-glutamate uptake"}
{"concept_id": "C4689702", "aliases": [], "types": ["T045"], "canonical_name": "nucleic acid binding transcription factor activity"}
{"concept_id": "C4689703", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcriptional cofactor activity"}
{"concept_id": "C4689704", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription co-activator activity"}
{"concept_id": "C4689705", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription coactivator activity"}
{"concept_id": "C4689706", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription mediator activity"}
{"concept_id": "C4689707", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription co-repressor activity"}
{"concept_id": "C4689708", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription corepressor activity"}
{"concept_id": "C4689709", "aliases": [], "types": ["T044"], "canonical_name": "ligase activity, forming aminoacyl-tRNA and related compounds"}
{"concept_id": "C4689710", "aliases": [], "types": ["T044"], "canonical_name": "extracellularly ATP-gated cation channel activity", "definition": "Enables the transmembrane transfer of a cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:bf, GOC:mah, PMID:9755289]"}
{"concept_id": "C4689711", "aliases": [], "types": ["T044"], "canonical_name": "exportin activity"}
{"concept_id": "C4689712", "aliases": [], "types": ["T044"], "canonical_name": "signaling receptor binding", "definition": "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]"}
{"concept_id": "C4689713", "aliases": [], "types": ["T044"], "canonical_name": "frizzled-2 binding"}
{"concept_id": "C4689714", "aliases": [], "types": ["T044"], "canonical_name": "frizzled-2 ligand"}
{"concept_id": "C4689715", "aliases": [], "types": ["T044"], "canonical_name": "fz2 binding"}
{"concept_id": "C4689716", "aliases": [], "types": ["T044"], "canonical_name": "fz2 ligand"}
{"concept_id": "C4689717", "aliases": [], "types": ["T044"], "canonical_name": "allantoin:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport. [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1]"}
{"concept_id": "C4689718", "aliases": ["fatty-acyl-CoA transmembrane transporter activity", "ABC-type fatty-acyl-CoA transporter", "fatty-acyl-CoA-transporting ATPase", "fatty acyl CoA transporter activity"], "types": ["T044"], "canonical_name": "ABC-type fatty-acyl-CoA transporter activity", "definition": "Catalysis of the reaction ATP + H(2)O + fatty acyl CoA(Side 1) <=> ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it. [RHEA:15181]"}
{"concept_id": "C4689721", "aliases": [], "types": ["T044"], "canonical_name": "sugar efflux transmembrane transporter activity"}
{"concept_id": "C4689722", "aliases": [], "types": ["T044"], "canonical_name": "copper uptake transmembrane transporter activity"}
{"concept_id": "C4689723", "aliases": [], "types": ["T044"], "canonical_name": "glycoprotein binding"}
{"concept_id": "C4689724", "aliases": [], "types": ["T026"], "canonical_name": "horsetail nucleus"}
{"concept_id": "C4689727", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organismal polysaccharide metabolic process"}
{"concept_id": "C4689728", "aliases": [], "types": ["T045"], "canonical_name": "transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript"}
{"concept_id": "C4689729", "aliases": [], "types": ["T045"], "canonical_name": "termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript"}
{"concept_id": "C4689730", "aliases": [], "types": ["T045"], "canonical_name": "transcription from a RNA polymerase III hybrid type promoter"}
{"concept_id": "C4689731", "aliases": [], "types": ["T045"], "canonical_name": "transcription from RNA polymerase III type 2 promoter"}
{"concept_id": "C4689732", "aliases": [], "types": ["T045"], "canonical_name": "transcription from RNA polymerase III type 3 promoter"}
{"concept_id": "C4689733", "aliases": [], "types": ["T045"], "canonical_name": "U2 snRNA transcription (S. cerevisiae)"}
{"concept_id": "C4689734", "aliases": [], "types": ["T045"], "canonical_name": "U6 snRNA transcription (mammalian)"}
{"concept_id": "C4689735", "aliases": [], "types": ["T045"], "canonical_name": "transcription initiation from RNA polymerase III hybrid type promoter"}
{"concept_id": "C4689736", "aliases": [], "types": ["T045"], "canonical_name": "transcription initiation from RNA polymerase III type 1 promoter"}
{"concept_id": "C4689737", "aliases": [], "types": ["T045"], "canonical_name": "transcription initiation from RNA polymerase III type 2 promoter"}
{"concept_id": "C4689738", "aliases": [], "types": ["T045"], "canonical_name": "transcription initiation from RNA polymerase III type 3 promoter"}
{"concept_id": "C4689739", "aliases": [], "types": ["T044"], "canonical_name": "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown"}
{"concept_id": "C4689740", "aliases": [], "types": ["T044"], "canonical_name": "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process"}
{"concept_id": "C4689741", "aliases": [], "types": ["T044"], "canonical_name": "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism"}
{"concept_id": "C4689742", "aliases": [], "types": ["T044"], "canonical_name": "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation"}
{"concept_id": "C4689743", "aliases": [], "types": ["T044"], "canonical_name": "protein ubiquitination during ubiquitin-dependent protein breakdown"}
{"concept_id": "C4689744", "aliases": [], "types": ["T044"], "canonical_name": "protein ubiquitination during ubiquitin-dependent protein catabolic process"}
{"concept_id": "C4689745", "aliases": [], "types": ["T044"], "canonical_name": "protein ubiquitination during ubiquitin-dependent protein catabolism"}
{"concept_id": "C4689746", "aliases": [], "types": ["T044"], "canonical_name": "protein ubiquitination during ubiquitin-dependent protein degradation"}
{"concept_id": "C4689747", "aliases": [], "types": ["T044"], "canonical_name": "protein ubiquitination involved in ubiquitin-dependent protein catabolic process"}
{"concept_id": "C4689748", "aliases": [], "types": ["T044"], "canonical_name": "protein ubiquitinylation during ubiquitin-dependent protein catabolic process"}
{"concept_id": "C4689749", "aliases": [], "types": ["T044"], "canonical_name": "protein ubiquitinylation during ubiquitin-dependent protein catabolism"}
{"concept_id": "C4689750", "aliases": [], "types": ["T044"], "canonical_name": "protein ubiquitylation during ubiquitin-dependent protein catabolic process"}
{"concept_id": "C4689751", "aliases": [], "types": ["T044"], "canonical_name": "protein ubiquitylation during ubiquitin-dependent protein catabolism"}
{"concept_id": "C4689752", "aliases": [], "types": ["T044"], "canonical_name": "protein quality control by the ubiquitin-proteasome system"}
{"concept_id": "C4689753", "aliases": [], "types": ["T043"], "canonical_name": "single-organism transport"}
{"concept_id": "C4689754", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial pyruvate transmembrane transport", "definition": "The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion. [GOC:vw, PMID:22628558]"}
{"concept_id": "C4689755", "aliases": ["pyruvate membrane transport in mitochondrion"], "types": ["T043"], "canonical_name": "pyruvate membrane transport in mitochondria"}
{"concept_id": "C4689756", "aliases": ["pyruvate transmembrane transport in mitochondrion"], "types": ["T044"], "canonical_name": "pyruvate transmembrane transport in mitochondria"}
{"concept_id": "C4689757", "aliases": ["single-organism membrane budding"], "types": ["T043"], "canonical_name": "single organism membrane budding"}
{"concept_id": "C4689758", "aliases": [], "types": ["T043"], "canonical_name": "single-organism pinocytosis"}
{"concept_id": "C4689759", "aliases": ["single organism organelle organization"], "types": ["T043"], "canonical_name": "single-organism organelle organization"}
{"concept_id": "C4689760", "aliases": ["mitotic spindle organisation in nucleus"], "types": ["T043"], "canonical_name": "mitotic spindle organization in nucleus"}
{"concept_id": "C4689761", "aliases": [], "types": ["T043"], "canonical_name": "mitotic spindle organization and biogenesis in cell nucleus"}
{"concept_id": "C4689762", "aliases": [], "types": ["T043"], "canonical_name": "mitotic spindle organization and biogenesis in nucleus"}
{"concept_id": "C4689763", "aliases": [], "types": ["T043"], "canonical_name": "spindle organization and biogenesis in nucleus during mitosis"}
{"concept_id": "C4689764", "aliases": [], "types": ["T043"], "canonical_name": "establishment of cell nucleus localization"}
{"concept_id": "C4689765", "aliases": ["establishment of nucleus localisation", "establishment of nucleus localization"], "types": ["T043"], "canonical_name": "establishment of localization of nucleus"}
{"concept_id": "C4689766", "aliases": [], "types": ["T043"], "canonical_name": "single organism cell adhesion"}
{"concept_id": "C4689767", "aliases": ["positive regulation of adenylate cyclase activity by G-protein signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of adenylate cyclase activity by G-protein signaling pathway"}
{"concept_id": "C4689768", "aliases": ["establishment of oocyte nucleus localization during oocyte axis determination"], "types": ["T043"], "canonical_name": "establishment of localization of oocyte nucleus during oocyte axis determination"}
{"concept_id": "C4689769", "aliases": ["establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification", "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification"], "types": ["T043"], "canonical_name": "establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification"}
{"concept_id": "C4689770", "aliases": [], "types": ["T043"], "canonical_name": "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination"}
{"concept_id": "C4689771", "aliases": [], "types": ["T043"], "canonical_name": "establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification"}
{"concept_id": "C4689772", "aliases": ["oocyte nucleus positioning during oocyte axis determination"], "types": ["T043"], "canonical_name": "nucleus positioning in oocyte during oocyte axis determination"}
{"concept_id": "C4689773", "aliases": [], "types": ["T043"], "canonical_name": "oocyte axis determination, establishment of localization of nucleus"}
{"concept_id": "C4689774", "aliases": [], "types": ["T043"], "canonical_name": "oocyte axis determination, establishment of oocyte nucleus localization"}
{"concept_id": "C4689775", "aliases": [], "types": ["T043"], "canonical_name": "oocyte axis determination, establishment of position of nucleus"}
{"concept_id": "C4689776", "aliases": [], "types": ["T043"], "canonical_name": "oocyte axis determination, positioning of nucleus"}
{"concept_id": "C4689777", "aliases": ["asymmetric protein localisation"], "types": ["T043"], "canonical_name": "asymmetric protein localization"}
{"concept_id": "C4689778", "aliases": [], "types": ["T043"], "canonical_name": "establishment and maintenance of asymmetric protein localization"}
{"concept_id": "C4689779", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organism metabolic process"}
{"concept_id": "C4689780", "aliases": ["KCNJ11-SUR complex location"], "types": ["T026"], "canonical_name": "KCNJ11-SUR complex"}
{"concept_id": "C4689781", "aliases": ["KCNJ11-SURx complex location"], "types": ["T026"], "canonical_name": "KCNJ11-SURx complex"}
{"concept_id": "C4689782", "aliases": ["KCNJ8-SUR complex location"], "types": ["T026"], "canonical_name": "KCNJ8-SUR complex"}
{"concept_id": "C4689783", "aliases": ["KCNJ8-SURx complex location"], "types": ["T026"], "canonical_name": "KCNJ8-SURx complex"}
{"concept_id": "C4689784", "aliases": ["Kir6-SUR complex location"], "types": ["T026"], "canonical_name": "Kir6-SUR complex"}
{"concept_id": "C4689785", "aliases": ["Kir6.1-SUR complex location"], "types": ["T026"], "canonical_name": "Kir6.1-SUR complex"}
{"concept_id": "C4689786", "aliases": ["Kir6.1-SURx complex location"], "types": ["T026"], "canonical_name": "Kir6.1-SURx complex"}
{"concept_id": "C4689787", "aliases": ["Kir6.2-SUR complex location"], "types": ["T026"], "canonical_name": "Kir6.2-SUR complex"}
{"concept_id": "C4689788", "aliases": ["Kir6.2-SURx complex location"], "types": ["T026"], "canonical_name": "Kir6.2-SURx complex"}
{"concept_id": "C4689789", "aliases": ["Kir6.x complex location"], "types": ["T026"], "canonical_name": "Kir6.x complex"}
{"concept_id": "C4689790", "aliases": ["Kir6.x-SURx complex location"], "types": ["T026"], "canonical_name": "Kir6.x-SURx complex"}
{"concept_id": "C4689791", "aliases": [], "types": ["T044"], "canonical_name": "protein channel activity"}
{"concept_id": "C4689792", "aliases": [], "types": ["T044"], "canonical_name": "vitamin D receptor activity"}
{"concept_id": "C4689793", "aliases": [], "types": ["T044"], "canonical_name": "folate:anion antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF. [GOC:mtg_transport, PMID:21568705, PMID:24745983, TC:2.A.48]"}
{"concept_id": "C4689794", "aliases": [], "types": ["T044"], "canonical_name": "reduced folate transmembrane transporter activity"}
{"concept_id": "C4689795", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-CoA transmembrane transporter activity", "definition": "Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. [GOC:ai]"}
{"concept_id": "C4689796", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin-like modifier activating enzyme activity", "definition": "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:jl, GOC:mah]"}
{"concept_id": "C4689797", "aliases": [], "types": ["T043"], "canonical_name": "hexose transmembrane transport", "definition": "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. [GOC:vw]"}
{"concept_id": "C4689798", "aliases": [], "types": ["T043"], "canonical_name": "hexose membrane transport"}
{"concept_id": "C4689799", "aliases": [], "types": ["T043"], "canonical_name": "high-affinity hexose transport"}
{"concept_id": "C4689800", "aliases": [], "types": ["T043"], "canonical_name": "low-affinity hexose transport"}
{"concept_id": "C4689801", "aliases": ["ICDH kinase/phosphatase activity", "IDH kinase/phosphatase activity", "isocitrate dehydrogenase kinase/phosphatase activity"], "types": ["T044"], "canonical_name": "isocitrate dehydrogenase kinase/phosphatase activity"}
{"concept_id": "C4689802", "aliases": [], "types": ["T044"], "canonical_name": "electron transfer activity", "definition": "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. [ISBN:0198506732]"}
{"concept_id": "C4689803", "aliases": [], "types": ["T044"], "canonical_name": "electron carrier"}
{"concept_id": "C4689804", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organismal catabolic process"}
{"concept_id": "C4689805", "aliases": [], "types": ["T040"], "canonical_name": "single-organism catabolic process"}
{"concept_id": "C4689806", "aliases": [], "types": ["T044"], "canonical_name": "multicellular organismal macromolecule catabolic process"}
{"concept_id": "C4689807", "aliases": [], "types": ["T038"], "canonical_name": "multicellular organismal biosynthetic process"}
{"concept_id": "C4689808", "aliases": [], "types": ["T038"], "canonical_name": "single-organism biosynthetic process"}
{"concept_id": "C4689809", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organismal oligosaccharide metabolic process"}
{"concept_id": "C4689810", "aliases": [], "types": ["T044"], "canonical_name": "multicellular organismal oligosaccharide catabolic process"}
{"concept_id": "C4689811", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of organismal metabolic process"}
{"concept_id": "C4689812", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of multicellular organismal metabolic process"}
{"concept_id": "C4689813", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of multicellular organismal metabolic process"}
{"concept_id": "C4689814", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of organismal metabolism"}
{"concept_id": "C4689815", "aliases": [], "types": ["T044"], "canonical_name": "stimulation of organismal metabolic process"}
{"concept_id": "C4689816", "aliases": [], "types": ["T044"], "canonical_name": "up-regulation of organismal metabolic process"}
{"concept_id": "C4689817", "aliases": [], "types": ["T043"], "canonical_name": "single-organism membrane invagination"}
{"concept_id": "C4689818", "aliases": ["regulation of signalling receptor activity"], "types": ["T044"], "canonical_name": "regulation of signaling receptor activity", "definition": "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. [GOC:dph, GOC:tb]"}
{"concept_id": "C4689819", "aliases": ["single-organism plasmodesmata-mediated intercellular transport"], "types": ["T043"], "canonical_name": "single organism plasmodesmata-mediated intercellular transport"}
{"concept_id": "C4689820", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glucose transmembrane transport", "definition": "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]"}
{"concept_id": "C4689821", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of glucose transmembrane transport", "definition": "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C4689822", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of glucose transmembrane transport", "definition": "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C4689823", "aliases": [], "types": ["T043"], "canonical_name": "regulation of amino acid import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of amino acid import into a cell. [GOC:dph, GOC:tb]"}
{"concept_id": "C4689824", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle"}
{"concept_id": "C4689829", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of division septum assembly involved in cell cycle cytokinesis"}
{"concept_id": "C4689830", "aliases": ["inhibition of formation of division septum involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "inhibition of division septum formation involved in mitotic cell cycle"}
{"concept_id": "C4689831", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of mitotic division septum assembly"}
{"concept_id": "C4689832", "aliases": [], "types": ["T043"], "canonical_name": "ubiquitin recycling", "definition": "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates. [GOC:BHF, GOC:dph, GOC:PG, GOC:tb, PMID:19410548]"}
{"concept_id": "C4689833", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ubiquitin homeostasis"}
{"concept_id": "C4689834", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic density of dendrite"}
{"concept_id": "C4689835", "aliases": [], "types": ["T044"], "canonical_name": "potassium uptake permease activity"}
{"concept_id": "C4689836", "aliases": [], "types": ["T044"], "canonical_name": "potassium uptake transmembrane transporter activity"}
{"concept_id": "C4689837", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity ferric iron transmembrane transporter activity", "definition": "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [GOC:ai, PMID:1447137]"}
{"concept_id": "C4689838", "aliases": [], "types": ["T044"], "canonical_name": "ferrous iron uptake transmembrane transporter activity"}
{"concept_id": "C4689839", "aliases": [], "types": ["T044"], "canonical_name": "tricarboxylate transport protein"}
{"concept_id": "C4689840", "aliases": [], "types": ["T044"], "canonical_name": "biopterin transmembrane transporter activity", "definition": "Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme. [ISBN:0198506732]"}
{"concept_id": "C4689841", "aliases": [], "types": ["T044"], "canonical_name": "biotin transmembrane transporter activity", "definition": "Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. [GOC:ai]"}
{"concept_id": "C4689842", "aliases": [], "types": ["T044"], "canonical_name": "FAD carrier activity"}
{"concept_id": "C4689843", "aliases": ["flavin-adenine dinucleotide carrier activity"], "types": ["T044"], "canonical_name": "flavin adenine dinucleotide carrier activity"}
{"concept_id": "C4689844", "aliases": [], "types": ["T044"], "canonical_name": "thiamin uptake transporter activity"}
{"concept_id": "C4689845", "aliases": [], "types": ["T044"], "canonical_name": "thiamine uptake transmembrane transporter activity"}
{"concept_id": "C4689846", "aliases": [], "types": ["T044"], "canonical_name": "drug transporter activity"}
{"concept_id": "C4689847", "aliases": [], "types": ["T044"], "canonical_name": "amiloride transmembrane transporter activity", "definition": "Enables the transfer of amiloride from one side of a membrane to the other. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic. [ISBN:0198506732]"}
{"concept_id": "C4689848", "aliases": [], "types": ["T044"], "canonical_name": "cycloheximide transmembrane transporter activity", "definition": "Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes. [ISBN:0198506732]"}
{"concept_id": "C4689849", "aliases": [], "types": ["T044"], "canonical_name": "fluconazole transmembrane transporter activity", "definition": "Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections. [GOC:curators]"}
{"concept_id": "C4689850", "aliases": ["fatty acyl transporter activity"], "types": ["T044"], "canonical_name": "fatty acid transmembrane transporter activity", "definition": "Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732]"}
{"concept_id": "C4689851", "aliases": [], "types": ["T044"], "canonical_name": "fatty-acyl group transporter activity"}
{"concept_id": "C4689852", "aliases": [], "types": ["T044"], "canonical_name": "aminophospholipid transmembrane transporter activity"}
{"concept_id": "C4689853", "aliases": [], "types": ["T044"], "canonical_name": "siderochrome transporter activity"}
{"concept_id": "C4689854", "aliases": [], "types": ["T044"], "canonical_name": "siderophore transporter activity"}
{"concept_id": "C4689855", "aliases": [], "types": ["T044"], "canonical_name": "methotrexate transmembrane transporter activity", "definition": "Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. [GOC:ai]"}
{"concept_id": "C4689856", "aliases": [], "types": ["T044"], "canonical_name": "potassium ion symporter activity"}
{"concept_id": "C4689857", "aliases": ["cobalamin porter activity"], "types": ["T044"], "canonical_name": "vitamin B12 porter activity"}
{"concept_id": "C4689858", "aliases": [], "types": ["T044"], "canonical_name": "cobalamin transporter activity"}
{"concept_id": "C4689859", "aliases": [], "types": ["T044"], "canonical_name": "vitamin B12 transporter activity"}
{"concept_id": "C4689860", "aliases": [], "types": ["T044"], "canonical_name": "formate uptake transmembrane transporter activity"}
{"concept_id": "C4689861", "aliases": [], "types": ["T044"], "canonical_name": "arabinose efflux permease activity"}
{"concept_id": "C4689862", "aliases": [], "types": ["T044"], "canonical_name": "arabinose efflux transmembrane transporter activity"}
{"concept_id": "C4689863", "aliases": [], "types": ["T044"], "canonical_name": "bicyclomycin transmembrane transporter activity", "definition": "Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive. [ISBN:091191028X]"}
{"concept_id": "C4689864", "aliases": [], "types": ["T044"], "canonical_name": "nalidixic acid transmembrane transporter activity", "definition": "Enables the transfer of nalidixic acid from one side of a membrane to the other. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication. [GOC:curators, PMID:12702699, PubChem_Compound:4221]"}
{"concept_id": "C4689865", "aliases": [], "types": ["T044"], "canonical_name": "organomercurial transmembrane transporter activity", "definition": "Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom. [GOC:ai, PMID:18793329]"}
{"concept_id": "C4689866", "aliases": [], "types": ["T044"], "canonical_name": "secondary active p-aminobenzoyl-glutamate transmembrane transporter activity", "definition": "Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid. [GOC:ai]"}
{"concept_id": "C4689867", "aliases": [], "types": ["T044"], "canonical_name": "p-aminobenzoyl-glutamate transmembrane transporter activity"}
{"concept_id": "C4689868", "aliases": [], "types": ["T044"], "canonical_name": "p-aminobenzoyl-glutamate transporter activity"}
{"concept_id": "C4689869", "aliases": [], "types": ["T044"], "canonical_name": "acriflavine transmembrane transporter activity", "definition": "Enables the directed movement of acriflavin from one side of a membrane to the other. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. [PubChem_Compound:6842]"}
{"concept_id": "C4689870", "aliases": [], "types": ["T044"], "canonical_name": "short-chain fatty acid transmembrane transporter activity", "definition": "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. Short-chain fatty acids are fatty acids with a chain length of less than C6. [GOC:mah]"}
{"concept_id": "C4689871", "aliases": [], "types": ["T044"], "canonical_name": "short-chain fatty acid transporter activity"}
{"concept_id": "C4689872", "aliases": [], "types": ["T044"], "canonical_name": "tellurite transmembrane transporter activity", "definition": "Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals. [GOC:ai]"}
{"concept_id": "C4689873", "aliases": [], "types": ["T043"], "canonical_name": "ferric iron transmembrane transport"}
{"concept_id": "C4689874", "aliases": ["low-affinity nitrate transport"], "types": ["T043"], "canonical_name": "low affinity nitrate transport"}
{"concept_id": "C4689875", "aliases": [], "types": ["T043"], "canonical_name": "silicic acid import"}
{"concept_id": "C4689876", "aliases": [], "types": ["T043"], "canonical_name": "silicon uptake"}
{"concept_id": "C4689877", "aliases": [], "types": ["T043"], "canonical_name": "phosphoglycerate transmembrane transport", "definition": "The process in which phosphoglycerate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:krc]"}
{"concept_id": "C4689878", "aliases": [], "types": ["T043"], "canonical_name": "L-idonate transmembrane transport", "definition": "The process in which L-idonate is transported across a lipid bilayer, from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. [GOC:krc]"}
{"concept_id": "C4689879", "aliases": [], "types": ["T043"], "canonical_name": "shikimate transmembrane transport", "definition": "The process in which shikimate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:krc]"}
{"concept_id": "C4689880", "aliases": [], "types": ["T043"], "canonical_name": "uronic acid transmembrane transport", "definition": "The process in which uronic acid is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:krc]"}
{"concept_id": "C4689881", "aliases": [], "types": ["T043"], "canonical_name": "hexuronate transmembrane transport", "definition": "The process in which hexuronate is transported across a lipid bilayer, from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6. [GOC:ai, ISBN:0198506732]"}
{"concept_id": "C4689882", "aliases": [], "types": ["T043"], "canonical_name": "galacturonate transmembrane transport", "definition": "The process in which galacturonate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:krc]"}
{"concept_id": "C4689883", "aliases": [], "types": ["T043"], "canonical_name": "glucuronate transmembrane transport", "definition": "The process in which glucuronate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:krc]"}
{"concept_id": "C4689884", "aliases": [], "types": ["T043"], "canonical_name": "tartrate transmembrane transport", "definition": "The process in which tartrate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:krc]"}
{"concept_id": "C4689885", "aliases": [], "types": ["T043"], "canonical_name": "pentose transmembrane transport", "definition": "The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule. [GOC:ai]"}
{"concept_id": "C4689886", "aliases": [], "types": ["T043"], "canonical_name": "arabinose transmembrane transport", "definition": "The process in which arabinose, a pentose monosaccharide that occurs in both D and L configurations, is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C4689887", "aliases": [], "types": ["T043"], "canonical_name": "D-ribose transmembrane transport", "definition": "The process in which D-ribose is transported across a lipid bilayer, from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. [GOC:ai]"}
{"concept_id": "C4689888", "aliases": [], "types": ["T043"], "canonical_name": "D-xylose transmembrane transport", "definition": "The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. [GOC:ai]"}
{"concept_id": "C4689889", "aliases": [], "types": ["T043"], "canonical_name": "allose transmembrane transport", "definition": "The process in which allose is transported across a lipid bilayer, from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. [GOC:ai]"}
{"concept_id": "C4689890", "aliases": [], "types": ["T043"], "canonical_name": "fructose transmembrane transport", "definition": "The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [GOC:ai]"}
{"concept_id": "C4689891", "aliases": [], "types": ["T043"], "canonical_name": "galactose transmembrane transport", "definition": "The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. [GOC:ai]"}
{"concept_id": "C4689892", "aliases": [], "types": ["T043"], "canonical_name": "mannose transmembrane transport", "definition": "The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. [GOC:ai]"}
{"concept_id": "C4689893", "aliases": [], "types": ["T043"], "canonical_name": "rhamnose transmembrane transport", "definition": "The process in which rhamnose is transported across a lipid bilayer, from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. [GOC:ai]"}
{"concept_id": "C4689894", "aliases": [], "types": ["T043"], "canonical_name": "nucleotide-sugar transmembrane transport", "definition": "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [ISBN:0198506732]"}
{"concept_id": "C4689895", "aliases": [], "types": ["T043"], "canonical_name": "CMP-N-acetylneuraminate transmembrane transport", "definition": "The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C4689896", "aliases": [], "types": ["T043"], "canonical_name": "UDP-glucuronic acid transmembrane transport", "definition": "The directed movement of UDP-glucuronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C4689897", "aliases": [], "types": ["T043"], "canonical_name": "UDP-N-acetylgalactosamine transmembrane transport", "definition": "The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C4689898", "aliases": [], "types": ["T043"], "canonical_name": "UDP-xylose transmembrane transport", "definition": "The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. [GOC:ai]"}
{"concept_id": "C4689899", "aliases": [], "types": ["T043"], "canonical_name": "arabinitol transmembrane transport", "definition": "The process in which arabitol is transported across a lipid bilayer, from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. [ISBN:0198506732]"}
{"concept_id": "C4689900", "aliases": [], "types": ["T043"], "canonical_name": "glycerol-3-phosphate transmembrane transport", "definition": "The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol. [GOC:ai]"}
{"concept_id": "C4689901", "aliases": [], "types": ["T043"], "canonical_name": "aspartate transmembrane transport", "definition": "The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:go_curators, ISBN:0198506732]"}
{"concept_id": "C4689902", "aliases": [], "types": ["T043"], "canonical_name": "L-glutamate transmembrane transport", "definition": "The directed movement of L-glutamate across a membrane. [PMID:21307582]"}
{"concept_id": "C4689903", "aliases": [], "types": ["T043"], "canonical_name": "L-lysine import"}
{"concept_id": "C4689904", "aliases": [], "types": ["T043"], "canonical_name": "lysine uptake"}
{"concept_id": "C4689905", "aliases": [], "types": ["T043"], "canonical_name": "L-serine import"}
{"concept_id": "C4689906", "aliases": [], "types": ["T043"], "canonical_name": "creatine transmembrane transport", "definition": "The directed movement of creatine across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]"}
{"concept_id": "C4689907", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organism lipid catabolic process"}
{"concept_id": "C4689908", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organismal lipid catabolic process"}
{"concept_id": "C4689909", "aliases": [], "types": ["T044"], "canonical_name": "multicellular organismal carbohydrate catabolic process"}
{"concept_id": "C4689910", "aliases": [], "types": ["T044"], "canonical_name": "single-organism carbohydrate catabolic process"}
{"concept_id": "C4689911", "aliases": [], "types": ["T044"], "canonical_name": "lipoate-protein ligase activity (lipoylation of glycine cleavage complex)"}
{"concept_id": "C4689912", "aliases": [], "types": ["T045"], "canonical_name": "bacterial sigma factor activity"}
{"concept_id": "C4689913", "aliases": [], "types": ["T045"], "canonical_name": "plastid sigma factor activity"}
{"concept_id": "C4689914", "aliases": [], "types": ["T045"], "canonical_name": "promoter selection factor activity"}
{"concept_id": "C4689915", "aliases": [], "types": ["T044"], "canonical_name": "nuclear pore activity"}
{"concept_id": "C4689916", "aliases": [], "types": ["T043"], "canonical_name": "cytoplasmic viral capsid transport"}
{"concept_id": "C4689917", "aliases": [], "types": ["T043"], "canonical_name": "intracellular viral capsid transport"}
{"concept_id": "C4689918", "aliases": [], "types": ["T043"], "canonical_name": "nuclear viral capsid transport"}
{"concept_id": "C4689919", "aliases": [], "types": ["T043"], "canonical_name": "viral capsid transport in host cell cytoplasm"}
{"concept_id": "C4689920", "aliases": [], "types": ["T043"], "canonical_name": "viral capsid transport in host cell nucleus"}
{"concept_id": "C4689921", "aliases": [], "types": ["T040"], "canonical_name": "single-organism reproductive behavior"}
{"concept_id": "C4689922", "aliases": [], "types": ["T040"], "canonical_name": "regulation of multicellular organismal metabolic process"}
{"concept_id": "C4689923", "aliases": [], "types": ["T040"], "canonical_name": "regulation of organismal metabolic process"}
{"concept_id": "C4689924", "aliases": [], "types": ["T044"], "canonical_name": "multicellular organismal protein metabolic process"}
{"concept_id": "C4689925", "aliases": [], "types": ["T026"], "canonical_name": "bacterium-containing vacuole"}
{"concept_id": "C4689926", "aliases": [], "types": ["T040"], "canonical_name": "single organism reproductive process"}
{"concept_id": "C4689927", "aliases": [], "types": ["T044"], "canonical_name": "uniporter activity z"}
{"concept_id": "C4689928", "aliases": [], "types": ["T044"], "canonical_name": "substrate-specific transmembrane transporter activity"}
{"concept_id": "C4689929", "aliases": [], "types": ["T044"], "canonical_name": "substrate-specific transporter activity"}
{"concept_id": "C4689930", "aliases": [], "types": ["T044"], "canonical_name": "uptake permease activity"}
{"concept_id": "C4689931", "aliases": [], "types": ["T043"], "canonical_name": "uptake transmembrane transporter activity"}
{"concept_id": "C4689932", "aliases": [], "types": ["T040"], "canonical_name": "single organism signaling"}
{"concept_id": "C4689933", "aliases": [], "types": ["T026"], "canonical_name": "ER to Golgi constitutive secretory pathway transport vesicle"}
{"concept_id": "C4689934", "aliases": [], "types": ["T040"], "canonical_name": "multicellular organismal protein catabolic process"}
{"concept_id": "C4689935", "aliases": [], "types": ["T043"], "canonical_name": "autophagy of peroxisome", "definition": "The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions. [GOC:autophagy, PMID:10547367, PMID:20083110]"}
{"concept_id": "C4689937", "aliases": ["down-regulation of synaptic vesicle fusion to presynaptic membrane", "downregulation of synaptic vesicle fusion to presynaptic membrane"], "types": ["T043"], "canonical_name": "down regulation of synaptic vesicle fusion to presynaptic membrane"}
{"concept_id": "C4689938", "aliases": [], "types": ["T044"], "canonical_name": "vitamin B6 transmembrane transporter activity", "definition": "Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other. [GOC:mah]"}
{"concept_id": "C4689939", "aliases": [], "types": ["T044"], "canonical_name": "riboflavin transmembrane transporter activity", "definition": "Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. [GOC:rn, PMID:16204239]"}
{"concept_id": "C4689940", "aliases": ["protein localization by the Cvt pathway"], "types": ["T043"], "canonical_name": "cytoplasm to vacuole transport by the Cvt pathway", "definition": "A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast. [PMID:12865942, PMID:15659643]"}
{"concept_id": "C4689941", "aliases": [], "types": ["T040"], "canonical_name": "single-multicellular organism process"}
{"concept_id": "C4689942", "aliases": [], "types": ["T042"], "canonical_name": "single-organism developmental process"}
{"concept_id": "C4689943", "aliases": [], "types": ["T044"], "canonical_name": "protein complex scaffold activity"}
{"concept_id": "C4689944", "aliases": [], "types": ["T043"], "canonical_name": "amino acid transmembrane export"}
{"concept_id": "C4689945", "aliases": ["protein-protein complex location"], "types": ["T026"], "canonical_name": "protein-protein complex"}
{"concept_id": "C4689946", "aliases": [], "types": ["T043"], "canonical_name": "cysteine export across plasma membrane", "definition": "The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:mlg]"}
{"concept_id": "C4689947", "aliases": ["establishment of ribosome localization"], "types": ["T039"], "canonical_name": "establishment of ribosome localisation"}
{"concept_id": "C4689948", "aliases": ["establishment of protein localization to Golgi", "establishment of protein localization in Golgi"], "types": ["T043"], "canonical_name": "establishment of protein localisation to Golgi"}
{"concept_id": "C4689949", "aliases": [], "types": ["T043"], "canonical_name": "establishment of protein localization to Golgi apparatus"}
{"concept_id": "C4689950", "aliases": ["protein targeting to Golgi"], "types": ["T043"], "canonical_name": "protein-Golgi targeting"}
{"concept_id": "C4689951", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial RNA polymerase promoter specificity activity"}
{"concept_id": "C4689952", "aliases": [], "types": ["T043"], "canonical_name": "protein-containing complex remodeling", "definition": "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. [GOC:BHF, GOC:mah, GOC:mtg_mpo, GOC:rl]"}
{"concept_id": "C4689953", "aliases": [], "types": ["T043"], "canonical_name": "protein targeting to nucleus"}
{"concept_id": "C4689954", "aliases": ["high-affinity iron ion transport"], "types": ["T044"], "canonical_name": "high affinity iron ion transport"}
{"concept_id": "C4689955", "aliases": ["low-affinity iron ion transport"], "types": ["T044"], "canonical_name": "low affinity iron ion transport"}
{"concept_id": "C4689956", "aliases": [], "types": ["T044"], "canonical_name": "low-affinity iron ion transmembrane transport"}
{"concept_id": "C4689957", "aliases": [], "types": ["T043"], "canonical_name": "gluconate transport"}
{"concept_id": "C4689958", "aliases": [], "types": ["T043"], "canonical_name": "regulation of gluconate transport"}
{"concept_id": "C4689959", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of gluconate transport"}
{"concept_id": "C4689960", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of gluconate transport"}
{"concept_id": "C4689961", "aliases": [], "types": ["T043"], "canonical_name": "activation of gluconate transport"}
{"concept_id": "C4689962", "aliases": [], "types": ["T043"], "canonical_name": "induction of gluconate transport"}
{"concept_id": "C4689963", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of gluconate transport"}
{"concept_id": "C4689964", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of gluconate transport"}
{"concept_id": "C4689965", "aliases": [], "types": ["T044"], "canonical_name": "oligopeptide transporter activity"}
{"concept_id": "C4689966", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to nuclear inner membrane", "definition": "A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane. [GOC:dgf, PMID:16929305]"}
{"concept_id": "C4689968", "aliases": [], "types": ["T043"], "canonical_name": "sodium export"}
{"concept_id": "C4689969", "aliases": [], "types": ["T043"], "canonical_name": "sodium ion export"}
{"concept_id": "C4689970", "aliases": ["m(6)A writer complex location"], "types": ["T026"], "canonical_name": "m(6)A writer complex"}
{"concept_id": "C4689971", "aliases": ["m6A methyltransferase complex location"], "types": ["T026"], "canonical_name": "m6A methyltransferase complex"}
{"concept_id": "C4689972", "aliases": ["METTL3-METTL14-WTAP methyltransferase complex location"], "types": ["T026"], "canonical_name": "METTL3-METTL14-WTAP methyltransferase complex"}
{"concept_id": "C4689973", "aliases": [], "types": ["T038"], "canonical_name": "activation of homeostatic process"}
{"concept_id": "C4689974", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of homeostatic process"}
{"concept_id": "C4689975", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of homeostatic process"}
{"concept_id": "C4689976", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of homeostatic process"}
{"concept_id": "C4689977", "aliases": [], "types": ["T038"], "canonical_name": "regulation of homeostatic process"}
{"concept_id": "C4689978", "aliases": [], "types": ["T044"], "canonical_name": "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances"}
{"concept_id": "C4689979", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of cholesterol homeostasis"}
{"concept_id": "C4689980", "aliases": [], "types": ["T039"], "canonical_name": "regulation of cholesterol homeostasis"}
{"concept_id": "C4689981", "aliases": [], "types": ["T043"], "canonical_name": "aldarate transmembrane transport", "definition": "The process in which aldarate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C4689982", "aliases": [], "types": ["T044"], "canonical_name": "D-glucarate transmembrane transport", "definition": "The process in which D-glucarate, the D-enantiomer of glucarate, is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C4689983", "aliases": [], "types": ["T043"], "canonical_name": "aldonate transmembrane transport", "definition": "The process in which aldonate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C4689984", "aliases": [], "types": ["T043"], "canonical_name": "D-glucuronate transmembrane transport", "definition": "The process in which D-glucuronate, the D-enantiomer of glucuronate, is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C4689985", "aliases": [], "types": ["T044"], "canonical_name": "D-galactonate transmembrane transport", "definition": "The process in which D-galactonate, the D-enantiomer of galactonate, is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah]"}
{"concept_id": "C4689986", "aliases": [], "types": ["T043"], "canonical_name": "L-arabinose transmembrane transport", "definition": "The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732]"}
{"concept_id": "C4689988", "aliases": [], "types": ["T044"], "canonical_name": "chloramphenicol transmembrane transporter activity", "definition": "Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C4689989", "aliases": [], "types": ["T044"], "canonical_name": "polymyxin transmembrane transporter activity", "definition": "Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C4689990", "aliases": [], "types": ["T044"], "canonical_name": "fosmidomycin transmembrane transporter activity", "definition": "Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other. [GOC:jl, PMID:12543685]"}
{"concept_id": "C4689991", "aliases": [], "types": ["T043"], "canonical_name": "arabinan transmembrane transport", "definition": "The process in which arabinan is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C4689992", "aliases": [], "types": ["T044"], "canonical_name": "xenobiotic transmembrane transporter activity", "definition": "Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]"}
{"concept_id": "C4689993", "aliases": [], "types": ["T044"], "canonical_name": "acridine transmembrane transporter activity", "definition": "Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C4689994", "aliases": [], "types": ["T044"], "canonical_name": "benzoate transmembrane transporter activity", "definition": "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other. [GOC:jl, ISBN:0721662544]"}
{"concept_id": "C4689995", "aliases": [], "types": ["T044"], "canonical_name": "ferrichrome transmembrane transporter activity", "definition": "Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. [GOC:jl, ISBN:0198506732]"}
{"concept_id": "C4689996", "aliases": [], "types": ["T044"], "canonical_name": "chrysobactin transmembrane transporter activity", "definition": "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other. [GOC:jl, PMID:8837459]"}
{"concept_id": "C4689997", "aliases": [], "types": ["T044"], "canonical_name": "achromobactin transmembrane transporter activity", "definition": "Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C4689998", "aliases": [], "types": ["T044"], "canonical_name": "tripeptide transmembrane transporter activity", "definition": "Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other. [GOC:jl]"}
{"concept_id": "C4689999", "aliases": [], "types": ["T044"], "canonical_name": "multicellular organismal macromolecule metabolic process"}
{"concept_id": "C4690000", "aliases": ["scaffoldin complex location"], "types": ["T026"], "canonical_name": "scaffoldin complex"}
{"concept_id": "C4690001", "aliases": [], "types": ["T044"], "canonical_name": "glycyl-radical enzyme activating activity", "definition": "Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM). [GOC:jl, PMID:24486374]"}
{"concept_id": "C4690002", "aliases": [], "types": ["T044"], "canonical_name": "methionine importer"}
{"concept_id": "C4690003", "aliases": [], "types": ["T044"], "canonical_name": "methionine importer activity"}
{"concept_id": "C4690004", "aliases": ["methionine-importing activity"], "types": ["T044"], "canonical_name": "methionine importing activity"}
{"concept_id": "C4690005", "aliases": [], "types": ["T045"], "canonical_name": "regulatory region DNA binding"}
{"concept_id": "C4690006", "aliases": [], "types": ["T026"], "canonical_name": "secondary dendrite"}
{"concept_id": "C4690007", "aliases": [], "types": ["T043"], "canonical_name": "single-organism micropinocytosis"}
{"concept_id": "C4690008", "aliases": [], "types": ["T043"], "canonical_name": "single-organism macropinocytosis"}
{"concept_id": "C4690009", "aliases": [], "types": ["T038"], "canonical_name": "symbiotic process"}
{"concept_id": "C4690010", "aliases": [], "types": ["T044"], "canonical_name": "cadystin transmembrane transporter activity"}
{"concept_id": "C4690011", "aliases": [], "types": ["T044"], "canonical_name": "phytochelatin transporter activity"}
{"concept_id": "C4690012", "aliases": [], "types": ["T043"], "canonical_name": "2-keto-3-deoxygluconate transmembrane transport", "definition": "The process in which 2-keto-3-deoxygluconate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:go_curators]"}
{"concept_id": "C4690013", "aliases": [], "types": ["T044"], "canonical_name": "regulation of STAT protein import into nucleus"}
{"concept_id": "C4690014", "aliases": [], "types": ["T044"], "canonical_name": "regulation of STAT protein nuclear translocation"}
{"concept_id": "C4690015", "aliases": [], "types": ["T043"], "canonical_name": "STAT protein import into nucleus"}
{"concept_id": "C4690016", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of STAT protein import into nucleus"}
{"concept_id": "C4690017", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of STAT protein nuclear translocation"}
{"concept_id": "C4690018", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of STAT protein import into nucleus"}
{"concept_id": "C4690019", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of STAT protein nuclear translocation"}
{"concept_id": "C4690020", "aliases": [], "types": ["T044"], "canonical_name": "active borate transmembrane transporter activity", "definition": "Enables the transport of borate across a membrane against the concentration gradient. [PMID:12447444]"}
{"concept_id": "C4690021", "aliases": [], "types": ["T044"], "canonical_name": "borate uptake transmembrane transporter activity"}
{"concept_id": "C4690022", "aliases": [], "types": ["T044"], "canonical_name": "D-alanine:poly(phosphoribitol) ligase (AMP-forming)"}
{"concept_id": "C4690023", "aliases": [], "types": ["T044"], "canonical_name": "vitamin D receptor activator activity"}
{"concept_id": "C4690024", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial iron ion transmembrane transport"}
{"concept_id": "C4690025", "aliases": [], "types": ["T044"], "canonical_name": "nucleotide kinase activity"}
{"concept_id": "C4690026", "aliases": [], "types": ["T039"], "canonical_name": "regulation of ion homeostasis"}
{"concept_id": "C4690027", "aliases": [], "types": ["T044"], "canonical_name": "phosphoserine residue binding", "definition": "Binding to a phosphorylated serine residue within a protein. [GOC:ai]"}
{"concept_id": "C4690028", "aliases": [], "types": ["T044"], "canonical_name": "phosphothreonine residue binding", "definition": "Binding to a phosphorylated threonine residue within a protein. [GOC:ai]"}
{"concept_id": "C4690029", "aliases": ["chaperone co-factor-dependent protein refolding"], "types": ["T044"], "canonical_name": "chaperone cofactor-dependent protein refolding", "definition": "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. [GOC:rb]"}
{"concept_id": "C4690030", "aliases": ["single-organism localization"], "types": ["T038"], "canonical_name": "single organism localization"}
{"concept_id": "C4690033", "aliases": ["protein oligomer biosynthetic process"], "types": ["T044"], "canonical_name": "protein oligomer biosynthesis"}
{"concept_id": "C4690034", "aliases": ["single organism cellular localization"], "types": ["T043"], "canonical_name": "single-organism cellular localization"}
{"concept_id": "C4690035", "aliases": [], "types": ["T038"], "canonical_name": "induction by symbiont of nodulation, tumor or growth in host"}
{"concept_id": "C4690036", "aliases": [], "types": ["T038"], "canonical_name": "induction by symbiont in host of tumor, nodule, or growth"}
{"concept_id": "C4690037", "aliases": [], "types": ["T038"], "canonical_name": "induction by symbiont in host of tumor, nodule, or growth containing transformed cells"}
{"concept_id": "C4690038", "aliases": [], "types": ["T038"], "canonical_name": "induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction"}
{"concept_id": "C4690039", "aliases": [], "types": ["T044"], "canonical_name": "SMAD protein import into nucleus"}
{"concept_id": "C4690040", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of SMAD protein signal transduction", "definition": "Any process that increases the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C4690041", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of SMAD protein signal transduction", "definition": "Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. [GOC:BHF, GOC:dph, GOC:tb]"}
{"concept_id": "C4690042", "aliases": [], "types": ["T043"], "canonical_name": "cortical reaction"}
{"concept_id": "C4690043", "aliases": [], "types": ["T044"], "canonical_name": "catenin import into nucleus"}
{"concept_id": "C4690044", "aliases": [], "types": ["T044"], "canonical_name": "regulation of catenin import into nucleus"}
{"concept_id": "C4690045", "aliases": [], "types": ["T044"], "canonical_name": "regulation of catenin protein nuclear translocation"}
{"concept_id": "C4690046", "aliases": [], "types": ["T043"], "canonical_name": "single-organism membrane organization"}
{"concept_id": "C4690047", "aliases": [], "types": ["T043"], "canonical_name": "single-organism membrane fusion"}
{"concept_id": "C4690048", "aliases": [], "types": ["T043"], "canonical_name": "release of sequestered calcium ion into cytosol by Golgi", "definition": "The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol. [GOC:dph, GOC:tb]"}
{"concept_id": "C4690049", "aliases": [], "types": ["T044"], "canonical_name": "importin activity"}
{"concept_id": "C4690050", "aliases": [], "types": ["T044"], "canonical_name": "E3 involved in endoplasmic reticulum-associated degradation"}
{"concept_id": "C4690051", "aliases": [], "types": ["T044"], "canonical_name": "ER-associated E3 ligase"}
{"concept_id": "C4690052", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin protein ligase activity involved in chloroplast disassembly"}
{"concept_id": "C4690053", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin protein ligase activity involved in ERAD pathway"}
{"concept_id": "C4690054", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin modification-dependent histone binding", "definition": "Binding to a histone protein in which a residue has been modified by ubiquitination. [GOC:dph, PMID:24526689]"}
{"concept_id": "C4690055", "aliases": [], "types": ["T044"], "canonical_name": "ferrous ion transmembrane transport"}
{"concept_id": "C4690056", "aliases": [], "types": ["T043"], "canonical_name": "hepatic stellate cell migration", "definition": "The orderly movement of a hepatic stellate cell from one site to another. [PMID:24204762]"}
{"concept_id": "C4690057", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hepatic stellate cell migration", "definition": "Any process that modulates the frequency, rate or extent of hepatic stellate cell migration. [PMID:24204762]"}
{"concept_id": "C4690058", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of hepatic stellate cell migration", "definition": "Any process that increases the frequency, rate or extent of hepatic stellate cell migration. [PMID:24204762]"}
{"concept_id": "C4690059", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of hepatic stellate cell migration", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell migration. [PMID:24204762]"}
{"concept_id": "C4690060", "aliases": [], "types": ["T043"], "canonical_name": "hepatic stellate cell contraction", "definition": "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a hepatic stellate cell. [PMID:24204762]"}
{"concept_id": "C4690061", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hepatic stellate cell contraction", "definition": "Any process that modulates the frequency, rate or extent of hepatic stellate cell contraction. [PMID:24204762]"}
{"concept_id": "C4690062", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of hepatic stellate cell contraction", "definition": "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell contraction. [PMID:24204762]"}
{"concept_id": "C4690063", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of hepatic stellate cell contraction", "definition": "Any process that modulates stops, prevents, or reduces the frequency, rate or extent of hepatic stellate cell contraction. [PMID:24204762]"}
{"concept_id": "C4690064", "aliases": ["regulation of anterograde axon transport of mitochondria"], "types": ["T043"], "canonical_name": "regulation of anterograde axonal transport of mitochondrion", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. [PMID:24302729]"}
{"concept_id": "C4690065", "aliases": ["positive regulation of anterograde axon transport of mitochondria"], "types": ["T043"], "canonical_name": "positive regulation of anterograde axonal transport of mitochondrion", "definition": "Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. [PMID:24302729]"}
{"concept_id": "C4690066", "aliases": ["negative regulation of anterograde axon transport of mitochondria"], "types": ["T043"], "canonical_name": "negative regulation of anterograde axonal transport of mitochondrion", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. [PMID:24302729]"}
{"concept_id": "C4690067", "aliases": ["clathrin-dependent endocytosis involved in yolk formation"], "types": ["T039"], "canonical_name": "clathrin-dependent endocytosis involved in vitellogenesis", "definition": "A clathrin-mediated endocytosis process whereby yolk proteins are internalized and trafficked through the endocytic pathway for yolk deposition. [PMID:26265702]"}
{"concept_id": "C4690068", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mini excitatory postsynaptic potential", "definition": "Any process that modulates the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse. [GOC:aruk, GOC:bc, PMID:20395454]"}
{"concept_id": "C4690069", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mini excitatory postsynaptic potential", "definition": "Any process that increases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse. [GOC:aruk, GOC:bc, PMID:20395454]"}
{"concept_id": "C4690070", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mini excitatory postsynaptic potential", "definition": "Any process that decreases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse. [GOC:aruk, GOC:bc, PMID:20395454]"}
{"concept_id": "C4690072", "aliases": [], "types": ["T043"], "canonical_name": "regulation of astrocyte activation", "definition": "Any process that modulates the frequency, rate or extent of astrocyte activation. [GOC:aruk, GOC:bc, PMID:20005821]"}
{"concept_id": "C4690073", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of astrocyte activation", "definition": "Any process that decreases the frequency, rate or extent of astrocyte activation. [GOC:aruk, GOC:bc, PMID:20005821]"}
{"concept_id": "C4690074", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of astrocyte activation", "definition": "Any process that increases the frequency, rate or extent of astrocyte activation. [GOC:aruk, GOC:bc, PMID:20005821]"}
{"concept_id": "C4690075", "aliases": [], "types": ["T044"], "canonical_name": "calcium ion sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+). [PMID:16005298, PMID:17020874, PMID:28151650]"}
{"concept_id": "C4690076", "aliases": [], "types": ["T044"], "canonical_name": "all-trans retinol 3,4-desaturase activity", "definition": "Catalysis of the reaction: all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]. [PMID:27059013]"}
{"concept_id": "C4690077", "aliases": [], "types": ["T044"], "canonical_name": "all-trans retinal 3,4-desaturase activity", "definition": "Catalysis of the reaction: all-trans-retinal + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized [adrenodoxin]. [PMID:27059013]"}
{"concept_id": "C4690078", "aliases": [], "types": ["T044"], "canonical_name": "all-trans retinoic acid 3,4-desaturase activity", "definition": "Catalysis of the reaction: all-trans-retinoic acid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]. [PMID:27059013]"}
{"concept_id": "C4690079", "aliases": [], "types": ["T044"], "canonical_name": "11-cis-retinal 3,4-desaturase activity", "definition": "Catalysis of the reaction: 11-cis-retinal + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized [adrenodoxin]. [PMID:27059013]"}
{"concept_id": "C4690080", "aliases": [], "types": ["T043"], "canonical_name": "glial cell activation", "definition": "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:aruk, GOC:bc, PMID:18723082]"}
{"concept_id": "C4690081", "aliases": [], "types": ["T040"], "canonical_name": "regulation of 1-phosphatidylinositol-3-kinase activity", "definition": "Any process that modulates the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity. [GOC:aruk, GOC:bc, PMID:18723082]"}
{"concept_id": "C4690082", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of 1-phosphatidylinositol-3-kinase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity. [GOC:aruk, GOC:bc, PMID:18723082]"}
{"concept_id": "C4690083", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of 1-phosphatidylinositol-3-kinase activity", "definition": "Any process that starts or increases the frequency or rate of 1-phosphatidylinositol-3-kinase activity. [GOC:aruk, GOC:bc, PMID:18723082]"}
{"concept_id": "C4690084", "aliases": [], "types": ["T043"], "canonical_name": "autophagosome localization", "definition": "Any process in which an autophagosome is transported to, and/or maintained in, a specific location within the cell. [PMID:26763909]"}
{"concept_id": "C4690085", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of AMPA receptor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor activity. [GOC:aruk, GOC:bc, PMID:20739563]"}
{"concept_id": "C4690086", "aliases": ["autophagosome-vacuole fusion"], "types": ["T043"], "canonical_name": "autophagosome-lysosome fusion", "definition": "The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome. [PMID:28077293]"}
{"concept_id": "C4690087", "aliases": [], "types": ["T043"], "canonical_name": "autophagosome-endosome fusion", "definition": "The process in which an autophagosome fuses with an endosome to create an intermediate autophagic organelle called amphisome. [PMID:24219988]"}
{"concept_id": "C4690088", "aliases": [], "types": ["T043"], "canonical_name": "amphisome-lysosome fusion", "definition": "The process in which amphisomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the amphisome. [PMID:24219988]"}
{"concept_id": "C4690089", "aliases": [], "types": ["T043"], "canonical_name": "selective autophagy", "definition": "The macroautophagy process in which specific structures are targeted by the autophagy process. [PMID:20484971, PMID:21997368, PMID:22966490]"}
{"concept_id": "C4690090", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of growth plate cartilage chondrocyte proliferation", "definition": "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. [PMID:19264869]"}
{"concept_id": "C4690091", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of growth plate cartilage chondrocyte proliferation", "definition": "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. [PMID:19264869]"}
{"concept_id": "C4690092", "aliases": ["actin fusion focus localisation"], "types": ["T043"], "canonical_name": "actin fusion focus localization", "definition": "Any process in which an actin fusion focus are transported to, or maintained in, a specific location. The actin fusion focus is an aster-like, F-actin-containing structure at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. [PMID:28410370]"}
{"concept_id": "C4690093", "aliases": ["distal tip of axonal growth cone", "axonal growth cone leading edge"], "types": ["T026"], "canonical_name": "leading edge of axonal growth cone", "definition": "That part of the axonal growth cone which represents the distal part of the structure. [PMID:16098134]"}
{"concept_id": "C4690094", "aliases": ["distal tip of dendritic growth cone", "dendritic growth cone leading edge"], "types": ["T026"], "canonical_name": "leading edge of dendritic growth cone", "definition": "That part of the dendritic growth cone which represents the distal part of the structure. [PMID:16098134]"}
{"concept_id": "C4690095", "aliases": [], "types": ["T043"], "canonical_name": "process utilizing autophagic mechanism", "definition": "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway. [PMID:21997368, PMID:22966490, PMID:28596378]"}
{"concept_id": "C4690096", "aliases": [], "types": ["T044"], "canonical_name": "protein propionyltransferase activity", "definition": "Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide. [PMID:17267393]"}
{"concept_id": "C4690097", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine propionylation", "definition": "The propionylation of peptidyl-lysine. [PMID:17267393]"}
{"concept_id": "C4690098", "aliases": [], "types": ["T044"], "canonical_name": "histone propionyltransferase activity", "definition": "Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone. [PMID:17267393]"}
{"concept_id": "C4690099", "aliases": [], "types": ["T044"], "canonical_name": "(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene. [PMID:27862766]"}
{"concept_id": "C4690100", "aliases": [], "types": ["T044"], "canonical_name": "protoillud-7-ene synthase activity"}
{"concept_id": "C4690101", "aliases": ["regulation of radial glial scaffold formation"], "types": ["T038"], "canonical_name": "regulation of formation of radial glial scaffolds", "definition": "Any process that modulates the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells. [PMID:22076441]"}
{"concept_id": "C4690102", "aliases": [], "types": ["T038"], "canonical_name": "regulation of Bergmann fiber biosynthesis"}
{"concept_id": "C4690103", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Bergmann fiber formation"}
{"concept_id": "C4690104", "aliases": ["negative regulation of radial glial scaffold formation"], "types": ["T043"], "canonical_name": "negative regulation of formation of radial glial scaffolds", "definition": "Any process that reduces the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells. [PMID:22076441]"}
{"concept_id": "C4690105", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Bergmann fiber biosynthesis"}
{"concept_id": "C4690106", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Bergmann fiber formation"}
{"concept_id": "C4690107", "aliases": ["positive regulation of radial glial scaffold formation"], "types": ["T043"], "canonical_name": "positive regulation of formation of radial glial scaffolds", "definition": "Any process that increases the frequency, rate or extent of the formation of radial glial cell scaffolds. [PMID:22076441]"}
{"concept_id": "C4690108", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Bergmann fiber biosynthesis"}
{"concept_id": "C4690109", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Bergmann fiber formation"}
{"concept_id": "C4690110", "aliases": [], "types": ["T044"], "canonical_name": "glutathione specific gamma-glutamylcyclotransferase activity", "definition": "Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine. [PMID:23070364, PMID:27913623]"}
{"concept_id": "C4690111", "aliases": [], "types": ["T044"], "canonical_name": "gamma-glutamylaminecyclotransferase activity", "definition": "Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline. [PMID:20110353, PMID:6107907]"}
{"concept_id": "C4690112", "aliases": [], "types": ["T043"], "canonical_name": "regulation of erythrocyte enucleation", "definition": "Any process that modulates the frequency, rate or extent of erythrocyte enucleation. [PMID:25241935]"}
{"concept_id": "C4690113", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of erythrocyte enucleation", "definition": "Any process that increases the frequency, rate or extent of erythrocyte enucleation. [PMID:25241935]"}
{"concept_id": "C4690114", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of erythrocyte enucleation", "definition": "Any process that decreases the frequency, rate or extent of erythrocyte enucleation. [PMID:25241935]"}
{"concept_id": "C4690115", "aliases": [], "types": ["T043"], "canonical_name": "regulation of adenine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of an adenine biosynthetic process. [PMID:19933844]"}
{"concept_id": "C4690116", "aliases": [], "types": ["T043"], "canonical_name": "fusion of sperm to egg plasma membrane involved in double fertilization forming two zygotes", "definition": "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming two zygotes. [GOC:dph]"}
{"concept_id": "C4690117", "aliases": [], "types": ["T043"], "canonical_name": "fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm", "definition": "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming a zygote and endosperm. [PMID:21123745]"}
{"concept_id": "C4690118", "aliases": ["somatodendritic protein localization"], "types": ["T043"], "canonical_name": "protein localization to somatodendritic compartment", "definition": "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment. [PMID:18341993]"}
{"concept_id": "C4690119", "aliases": ["cyclic di-GMP signaling", "cyclic diguanylate signaling", "cyclic di-(3':5')-guanosine monophosphate signaling", "3',5'-cyclic di-GMP signaling"], "types": ["T043"], "canonical_name": "c-di-GMP signaling", "definition": "Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal. [PMID:22864416, PMID:28057864]"}
{"concept_id": "C4690120", "aliases": [], "types": ["T043"], "canonical_name": "regulation of c-di-GMP signaling", "definition": "Any process that modulates the rate frequency or extent of c-di-GMP signaling. [PMID:22864416]"}
{"concept_id": "C4690121", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of c-di-GMP signaling", "definition": "Any process that increases the rate, frequency or extent of c-di-GMP signaling. [PMID:22864416]"}
{"concept_id": "C4690122", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of c-di-GMP signaling", "definition": "Any process that decreases the rate, frequency or extent of c-di-GMP signaling. [PMID:22864416]"}
{"concept_id": "C4690123", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein K48-linked ubiquitination", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. [GOC:BHF, GOC:rph, PMID:23460740]"}
{"concept_id": "C4690124", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein K48-linked ubiquitination", "definition": "Any process that modulates the rate, frequency or extent of protein K-48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. [PMID:23460740]"}
{"concept_id": "C4690125", "aliases": ["spontaneous acrosome loss"], "types": ["T038"], "canonical_name": "premature acrosome loss", "definition": "The discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents. [PMID:19153666, PMID:21380641, PMID:26655718]"}
{"concept_id": "C4690126", "aliases": [], "types": ["T038"], "canonical_name": "regulation of premature acrosome loss", "definition": "Any process that modulates the rate, frequency or extent of the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents. [PMID:22228629, PMID:23430248]"}
{"concept_id": "C4690127", "aliases": ["negative regulation of spontaneous acrosome loss"], "types": ["T038"], "canonical_name": "negative regulation of premature acrosome loss", "definition": "Any process that stops, prevents or reduces the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents. [PMID:22228629, PMID:23430248]"}
{"concept_id": "C4690128", "aliases": [], "types": ["T043"], "canonical_name": "establishment of protein localization to plasma membrane", "definition": "The directed movement of a protein to a specific location in a plasma membrane. [GOC:dph, GOC:vw]"}
{"concept_id": "C4690129", "aliases": ["cytokinetic abscission", "cell separation during cytokinesis"], "types": ["T043"], "canonical_name": "midbody abscission", "definition": "The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells. [PMID:12737809, PMID:29903934]"}
{"concept_id": "C4690130", "aliases": [], "types": ["T045"], "canonical_name": "mRNA (adenine-N1-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA. [PMID:29072297]"}
{"concept_id": "C4690131", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of actin filament polymerization involved in sperm capacitation", "definition": "Any process that icreases the rate or extent of actin polymerization as part of sperm capacitation. This process prevents a spontaneous acrosome reaction. [PMID:15749953, PMID:25966627, PMID:26514336, PMID:27178669]"}
{"concept_id": "C4690132", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of actin filament depolymerization involved in acrosome reaction", "definition": "Any process that increases the rate or exent of actin depolymerization as part of the acrosome reaction. This allows the acrosomal membrane and plasma membrane to fuse. [PMID:20937821]"}
{"concept_id": "C4690133", "aliases": ["penetration of cumulus mass", "penetration of cumulus cells layer"], "types": ["T043"], "canonical_name": "penetration of cumulus oophorus", "definition": "The infiltration by sperm of the cumulus oophorus to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. [PMID:21380641]"}
{"concept_id": "C4690134", "aliases": ["NVT complex location"], "types": ["T026"], "canonical_name": "NVT complex", "definition": "A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1. [PMID:26365378]"}
{"concept_id": "C4690135", "aliases": ["response to L-carnitine"], "types": ["T043"], "canonical_name": "response to (R)-carnitine", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an (R)-carnitine stimulus. [PMID:28102299]"}
{"concept_id": "C4690136", "aliases": [], "types": ["T044"], "canonical_name": "regulation of heme oxygenase activity", "definition": "Any process that modulates the frequency, or rate of heme oxygenase activity. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779]"}
{"concept_id": "C4690137", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of heme oxygenase activity", "definition": "Any process that activates or increases the frequency or rate of heme oxygenase activity. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779]"}
{"concept_id": "C4690138", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of heme oxygenase activity", "definition": "Any process that stops, prevents, or reduces the frequency or rate of heme oxygenase activity. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779]"}
{"concept_id": "C4690139", "aliases": [], "types": ["T038"], "canonical_name": "regulation of entry into reproductive diapause", "definition": "Any process that modulates the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. [GOC:ha, PMID:27689881]"}
{"concept_id": "C4690140", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of entry into reproductive diapause", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. [GOC:ha, PMID:27689881]"}
{"concept_id": "C4690141", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of entry into reproductive diapause", "definition": "Any process that activates or increases the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. [GOC:ha, PMID:27689881]"}
{"concept_id": "C4690142", "aliases": [], "types": ["T040"], "canonical_name": "establishment of left/right asymmetry", "definition": "The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves. [GOC:BHF, PMID:18629866]"}
{"concept_id": "C4690143", "aliases": [], "types": ["T040"], "canonical_name": "establishment of left sidedness", "definition": "The initial formation of the type asymmetry in an organism's body plan or part of an organism that established the pattern characteristic to its left side. [GOC:18629866, GOC:BHF]"}
{"concept_id": "C4690144", "aliases": [], "types": ["T042"], "canonical_name": "maintenance of left/right asymmetry", "definition": "The organization process that preserves the asymmetry in an organism's body plan or part of an organism with respect to the left and right halves. [GOC:BHF, PMID:18629866]"}
{"concept_id": "C4690145", "aliases": [], "types": ["T039"], "canonical_name": "maintenance of left sidedness", "definition": "The organization process that preserves the left sidedness in an organism's body plan or part of an organism with respect to the left and right halves. [GOC:BHF, PMID:18629866]"}
{"concept_id": "C4690146", "aliases": [], "types": ["T038"], "canonical_name": "maintenance of right sidedness", "definition": "The organization process that preserves the right sidedness in an organism's body plan or part of an organism with respect to the left and right halves. [GOC:BHF, PMID:18629866]"}
{"concept_id": "C4690147", "aliases": [], "types": ["T040"], "canonical_name": "replacement bone morphogenesis", "definition": "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. [DOI:10.1002/(SICI)1097-4687(199608)229:2<121::AID-JMOR1>3.0.CO;2-4]"}
{"concept_id": "C4690148", "aliases": [], "types": ["T040"], "canonical_name": "dermal bone morphogenesis", "definition": "The process in which bone which forms superficially in the organism are generated and organized. [PMID:12588850, PMID:15003632]"}
{"concept_id": "C4690149", "aliases": [], "types": ["T040"], "canonical_name": "perichondral bone morphogenesis", "definition": "The process in which bones are generated and organized as a result of the conversion of initial connective tissue surrounding cartilage into bone. [PMID:21901110]"}
{"concept_id": "C4690150", "aliases": ["articular cartilage of joint development"], "types": ["T039"], "canonical_name": "articular cartilage development", "definition": "The process whose specific outcome is the progression of articular cartilage over time, from its formation to the mature structure. [PMID:20097540, PMID:20679519]"}
{"concept_id": "C4690151", "aliases": [], "types": ["T039"], "canonical_name": "temporomandibular joint articular cartilage development", "definition": "The process whose specific outcome is the progression of temporomandibular joint articular cartilage over time, from its formation to the mature structure. [PMID:20679519]"}
{"concept_id": "C4690152", "aliases": [], "types": ["T042"], "canonical_name": "hip joint articular cartilage development", "definition": "The process whose specific outcome is the progression of hip joint articular cartilage over time, from its formation to the mature structure. [PMID:20097540]"}
{"concept_id": "C4690153", "aliases": [], "types": ["T042"], "canonical_name": "mandibular condyle articular cartilage development", "definition": "The process whose specific outcome is the progression of mandibular joint condyle articular cartilage over time, from its formation to the mature structure. [PMID:20679519]"}
{"concept_id": "C4690154", "aliases": [], "types": ["T042"], "canonical_name": "femoral head articular cartilage development", "definition": "The process whose specific outcome is the progression of femoral head articular cartilage over time, from its formation to the mature structure. [PMID:20097540]"}
{"concept_id": "C4690155", "aliases": [], "types": ["T045"], "canonical_name": "regulatory RNA binding", "definition": "Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme. [PMID:14622403, PMID:23475961]"}
{"concept_id": "C4690156", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxykynureninase activity", "definition": "Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. [PMID:17300176]"}
{"concept_id": "C4690157", "aliases": ["first meiotic cell division"], "types": ["T043"], "canonical_name": "meiosis I cell cycle process", "definition": "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs. [PMID:29385397]"}
{"concept_id": "C4690158", "aliases": ["second meiotic division"], "types": ["T043"], "canonical_name": "meiosis II cell cycle process", "definition": "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes. [PMID:29385397]"}
{"concept_id": "C4690159", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription by glucose", "definition": "Any process involving glucose that decreases the frequency, rate or extent or transcription. [PMID:11875061]"}
{"concept_id": "C4690160", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of transcription from RNA polymerase II promoter by glucose", "definition": "Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter. [PMID:11875061]"}
{"concept_id": "C4690161", "aliases": [], "types": ["T043"], "canonical_name": "karyosome formation", "definition": "The chromosome organization process in which meiotic chromosomes in the germ cell nucleus cluster together to form a compact spherical structure called the karyosome. [PMID:19696886]"}
{"concept_id": "C4690162", "aliases": [], "types": ["T043"], "canonical_name": "sperm karyosome formation", "definition": "The chromosome organization process in which meiotic chromosomes in the spem nucleus cluster together to form a compact spherical structure called the karyosome. [PMID:19696886]"}
{"concept_id": "C4690163", "aliases": [], "types": ["T044"], "canonical_name": "beta-ketodecanoyl-[acyl-carrier-protein] synthase activity", "definition": "Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2. [EC:2.3.1.207, PMID:22753057]"}
{"concept_id": "C4690165", "aliases": ["calcium:proton antiporter complex location"], "types": ["T026"], "canonical_name": "calcium:proton antiporter complex", "definition": "A protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in). [GOC:bhm, PMID:19098009, PMID:28645169]"}
{"concept_id": "C4690166", "aliases": [], "types": ["T026"], "canonical_name": "CAX1 homodimer"}
{"concept_id": "C4690167", "aliases": ["CAX1-CAX3 complex location"], "types": ["T026"], "canonical_name": "CAX1-CAX3 complex"}
{"concept_id": "C4690168", "aliases": [], "types": ["T026"], "canonical_name": "CAX3 homodimer"}
{"concept_id": "C4690170", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent protein-DNA complex displacement activity", "definition": "An activity that displaces proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion, driven by ATP hydrolysis. [PMID:18593879]"}
{"concept_id": "C4690171", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardiac endothelial to mesenchymal transition", "definition": "Any process that modulates the frequency, rate or extent of cardiac endothelial to mesenchymal transition. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067]"}
{"concept_id": "C4690172", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cardiac endothelial to mesenchymal transition", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac endothelial to mesenchymal trnasition. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067]"}
{"concept_id": "C4690173", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cardiac endothelial to mesenchymal transition", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac endothelial to mesenchymal transition. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067]"}
{"concept_id": "C4690174", "aliases": [], "types": ["T044"], "canonical_name": "regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity", "definition": "Any process that modulates the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. [PMID:23407971]"}
{"concept_id": "C4690175", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity", "definition": "Any process that decreases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. [PMID:23407971]"}
{"concept_id": "C4690176", "aliases": [], "types": ["T042"], "canonical_name": "secondary palate development", "definition": "The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences. [PMID:28784960]"}
{"concept_id": "C4690177", "aliases": ["COX1 preassemply complex", "mitochondrial respiratory chain complex IV pre-assembly complex location", "COX1 preassemply complex location"], "types": ["T026"], "canonical_name": "mitochondrial respiratory chain complex IV pre-assembly complex", "definition": "A protein complex that contributes to and regulates mitochondrial respiratory chain complex IV (COX) formation. It acts by regulating mitochondrial COX1 translation and by promoting the assembly of COX components. [GOC:lnp, PMID:21068384]"}
{"concept_id": "C4690178", "aliases": ["COX pre-assemply complex location"], "types": ["T026"], "canonical_name": "COX pre-assemply complex"}
{"concept_id": "C4690179", "aliases": ["regulation of small molecule metabolism"], "types": ["T044"], "canonical_name": "regulation of small molecule metabolic process", "definition": "Any process that modulates the rate, frequency or extent of a small molecule metabolic process. [GOC:vw]"}
{"concept_id": "C4690180", "aliases": ["positive regulation of small molecule metabolism"], "types": ["T044"], "canonical_name": "positive regulation of small molecule metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. [GOC:vw]"}
{"concept_id": "C4690181", "aliases": ["negative regulation of small molecule metabolism"], "types": ["T044"], "canonical_name": "negative regulation of small molecule metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. [GOC:vw]"}
{"concept_id": "C4690182", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cohesin dsDNA (leading strand) loading", "definition": "The protein localization to chromatin by which a cohesin ring complex is topologically linked to dsDNA (leading strand) as part of the mitotic cell cycle. [GOC:vw, PMID:29358048]"}
{"concept_id": "C4690183", "aliases": ["second-DNA capture"], "types": ["T043"], "canonical_name": "mitotic cohesin ssDNA (lagging strand) loading", "definition": "The ATP-dependent protein localization to chromatin by which a cohesin ring complex is topologically linked to ssDNA (lagging strand) which is already linked to a dsDNA (leading strand) molecule as part of the mitotic cell cycle. [GOC:vw, PMID:29358048]"}
{"concept_id": "C4690184", "aliases": [], "types": ["T026"], "canonical_name": "collagen-containing extracellular matrix", "definition": "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617]"}
{"concept_id": "C4690185", "aliases": [], "types": ["T043"], "canonical_name": "regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "definition": "Any process that modualtes the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. [PMID:28007894]"}
{"concept_id": "C4690186", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process", "definition": "Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. [PMID:28007894]"}
{"concept_id": "C4690187", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process", "definition": "Any process that starts or increases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. [PMID:28007894]"}
{"concept_id": "C4690188", "aliases": [], "types": ["T040"], "canonical_name": "regulation of stress granule assembly", "definition": "Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. [PMID:20180778]"}
{"concept_id": "C4690189", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of stress granule assembly", "definition": "Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. [PMID:20180778]"}
{"concept_id": "C4690190", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of stress granule assembly", "definition": "Any process that stops or decreases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. [PMID:20180778]"}
{"concept_id": "C4690191", "aliases": [], "types": ["T044"], "canonical_name": "filamentous growth MAPK cascade", "definition": "The MAPK cascade which is activated as a result of partial nutrient deprivation and which results in filamentous growth. [PMID:17604854]"}
{"concept_id": "C4690192", "aliases": ["cichorine synthesis", "cichorine anabolism", "cichorine biosynthesis", "cichorine formation"], "types": ["T044"], "canonical_name": "cichorine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of cichorine, a secondary metabolite found in some species of fungi. [PMID:24244835]"}
{"concept_id": "C4690193", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic sister chromatid segregation", "definition": "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. [PMID:12773390]"}
{"concept_id": "C4690194", "aliases": ["L-pipecolate biosynthetic process"], "types": ["T044"], "canonical_name": "L-pipecolic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-pipecolic acid, a metabolite of lysine. [PMID:27758894, PMID:28330936]"}
{"concept_id": "C4690195", "aliases": [], "types": ["T040"], "canonical_name": "sensory perception of cold stimulus", "definition": "The series of events required for an organism to receive a cold temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. [PMID:21335241]"}
{"concept_id": "C4690196", "aliases": [], "types": ["T040"], "canonical_name": "sensory perception of hot stimulus", "definition": "The series of events required for an organism to receive a hot temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. [PMID:21335241]"}
{"concept_id": "C4690197", "aliases": ["DNA displacement loop binding"], "types": ["T045"], "canonical_name": "D-loop DNA binding", "definition": "Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind. [PMID:20924116]"}
{"concept_id": "C4690198", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pheromone response MAPK cascade", "definition": "Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade. [PMID:9315645]"}
{"concept_id": "C4690199", "aliases": [], "types": ["T123"], "definition": "A structure lying external to microbial cells. A biofilm is an aggregate of surface-associated cells, and the biofilm matrix is the envelope of polymeric substances that surrounds the cells. [GOC:BHF, PMID:22571672, PMID:27129222, PMID:28516088]", "canonical_name": "biofilm matrix"}
{"concept_id": "C4690200", "aliases": [], "types": ["T026"], "canonical_name": "fungal biofilm matrix", "definition": "An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses. [GOC:BHF, PMID:27129222, PMID:28516088]"}
{"concept_id": "C4690201", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of meiotic sister chromatid arm separation", "definition": "Any process that increases the rate or exent of meiotic sister chromatid arm separation, the cell cycle process in which sister chromatid arms are physically detached from each other during meiosis. [PMID:20383139]"}
{"concept_id": "C4690202", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardiac epithelial to mesenchymal transition", "definition": "Any process that modulates the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:rph, PMID:20951801]"}
{"concept_id": "C4690203", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cardiac epithelial to mesenchymal transition", "definition": "Any process that starts or increases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:rph, PMID:20951801]"}
{"concept_id": "C4690204", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cardiac epithelial to mesenchymal transition", "definition": "Any process that stops or decreases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BFH, GOC:rph, PMID:20951801]"}
{"concept_id": "C4690205", "aliases": [], "types": ["T044"], "canonical_name": "L-lysine alpha-aminotransferase", "definition": "Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine. [PMID:27758894, PMID:28330936]"}
{"concept_id": "C4690206", "aliases": [], "types": ["T044"], "canonical_name": "dehydropipecolic acid reductase", "definition": "Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+. [PMID:27758894, PMID:28330936]"}
{"concept_id": "C4690207", "aliases": [], "types": ["T044"], "canonical_name": "pipecolic acid N-hydroxylase", "definition": "Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O. [PMID:27758894, PMID:28330936]"}
{"concept_id": "C4690208", "aliases": ["lymphotoxin complex location"], "types": ["T026"], "canonical_name": "lymphotoxin complex", "definition": "A homo- or heterotrimeric protein containing complex consisting of alpha and beta lymphotoxin subunits in different stoichiometric combinations. [PMID:1733951]"}
{"concept_id": "C4690209", "aliases": [], "types": ["T026"], "canonical_name": "lymphotoxin alpha-beta"}
{"concept_id": "C4690210", "aliases": ["cellular protein complex assembly"], "types": ["T043"], "canonical_name": "protein-containing complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. [GOC:jl]"}
{"concept_id": "C4690211", "aliases": [], "types": ["T044"], "canonical_name": "protein complex assembly"}
{"concept_id": "C4690212", "aliases": [], "types": ["T044"], "canonical_name": "protein complex formation"}
{"concept_id": "C4690213", "aliases": ["inner membrane pellicle complex location"], "types": ["T026"], "canonical_name": "inner membrane pellicle complex", "definition": "A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell. [GOC:mah, PMID:12456714]"}
{"concept_id": "C4690214", "aliases": [], "types": ["T044"], "canonical_name": "glycerol-2-phosphate transmembrane transport", "definition": "The process in which glycerol-2-phosphate is transported across a membrane. Glycerol-2-phosphate is a phosphoric monoester of glycerol. [GOC:mah]"}
{"concept_id": "C4690215", "aliases": [], "types": ["T044"], "canonical_name": "NFAT protein import into nucleus"}
{"concept_id": "C4690216", "aliases": [], "types": ["T044"], "canonical_name": "regulation of NFAT protein import into nucleus"}
{"concept_id": "C4690217", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of NFAT protein import into nucleus"}
{"concept_id": "C4690218", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of NFAT protein import into nucleus"}
{"concept_id": "C4690219", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of NFAT protein import into nucleus"}
{"concept_id": "C4690220", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly"}
{"concept_id": "C4690221", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly"}
{"concept_id": "C4690222", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly"}
{"concept_id": "C4690223", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly"}
{"concept_id": "C4690224", "aliases": ["homomeric SMAD protein complex location"], "types": ["T026"], "canonical_name": "homomeric SMAD protein complex", "definition": "A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive. [GOC:bhm, GOC:mah, PMID:11779505, PMID:16322555, PMID:9670020]"}
{"concept_id": "C4690225", "aliases": ["SMAD1 homotrimer complex location"], "types": ["T026"], "canonical_name": "SMAD1 homotrimer complex"}
{"concept_id": "C4690226", "aliases": ["SMAD1 protein complex location"], "types": ["T026"], "canonical_name": "SMAD1 protein complex"}
{"concept_id": "C4690227", "aliases": ["SMAD3 homotrimer complex location"], "types": ["T026"], "canonical_name": "SMAD3 homotrimer complex"}
{"concept_id": "C4690228", "aliases": ["SMAD3 protein complex location"], "types": ["T026"], "canonical_name": "SMAD3 protein complex"}
{"concept_id": "C4690229", "aliases": ["SMAD1-SMAD4 protein complex location"], "types": ["T026"], "canonical_name": "SMAD1-SMAD4 protein complex"}
{"concept_id": "C4690230", "aliases": ["SMAD2-SMAD3-SMAD4 protein complex location"], "types": ["T026"], "canonical_name": "SMAD2-SMAD3-SMAD4 protein complex"}
{"concept_id": "C4690231", "aliases": ["SMAD2-SMAD4 protein complex location"], "types": ["T026"], "canonical_name": "SMAD2-SMAD4 protein complex"}
{"concept_id": "C4690232", "aliases": ["SMAD3-SMAD4 protein complex location"], "types": ["T026"], "canonical_name": "SMAD3-SMAD4 protein complex"}
{"concept_id": "C4690233", "aliases": [], "types": ["T043"], "canonical_name": "response to high density lipoprotein particle"}
{"concept_id": "C4690234", "aliases": [], "types": ["T043"], "canonical_name": "response to high density lipoprotein particle stimulus"}
{"concept_id": "C4690235", "aliases": ["response to low density lipoprotein particle"], "types": ["T043"], "canonical_name": "response to low-density lipoprotein particle"}
{"concept_id": "C4690236", "aliases": [], "types": ["T043"], "canonical_name": "response to low-density lipoprotein particle stimulus"}
{"concept_id": "C4690237", "aliases": [], "types": ["T043"], "canonical_name": "high-affinity zinc II ion transmembrane import"}
{"concept_id": "C4690238", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity zinc II ion transport"}
{"concept_id": "C4690239", "aliases": [], "types": ["T043"], "canonical_name": "low-affinity zinc II ion transport"}
{"concept_id": "C4690240", "aliases": [], "types": ["T044"], "canonical_name": "zinc ion transmembrane import"}
{"concept_id": "C4690241", "aliases": ["high-affinity potassium ion import"], "types": ["T044"], "canonical_name": "high affinity potassium ion import"}
{"concept_id": "C4690242", "aliases": ["high-affinity potassium ion uptake"], "types": ["T044"], "canonical_name": "high affinity potassium ion uptake"}
{"concept_id": "C4690243", "aliases": [], "types": ["T044"], "canonical_name": "dipeptide transporter activity"}
{"concept_id": "C4690244", "aliases": [], "types": ["T043"], "canonical_name": "UDP-galactose transport"}
{"concept_id": "C4690245", "aliases": ["protein-plasma membrane targeting"], "types": ["T043"], "canonical_name": "protein targeting to plasma membrane"}
{"concept_id": "C4690246", "aliases": [], "types": ["T039"], "canonical_name": "symbiotic process benefiting host", "definition": "A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism, that is beneficial to the host organism. [GOC:pdt]"}
{"concept_id": "C4690247", "aliases": [], "types": ["T043"], "canonical_name": "amino acid transmembrane import"}
{"concept_id": "C4690248", "aliases": [], "types": ["T043"], "canonical_name": "L-amino acid import"}
{"concept_id": "C4690249", "aliases": [], "types": ["T043"], "canonical_name": "L-amino acid uptake"}
{"concept_id": "C4690250", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of catenin import into nucleus"}
{"concept_id": "C4690251", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of catenin protein nuclear translocation"}
{"concept_id": "C4690252", "aliases": [], "types": ["T043"], "canonical_name": "protein-containing complex assembly involved in synapse maturation", "definition": "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C4690253", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis"}
{"concept_id": "C4690254", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of catenin import into nucleus"}
{"concept_id": "C4690255", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of catenin protein nuclear translocation"}
{"concept_id": "C4690256", "aliases": [], "types": ["T044"], "canonical_name": "N-methylnicotinate transmembrane transporter activity", "definition": "Enables the transfer of N-methylnicotinate from one side of a membrane to the other. [GOC:tb]"}
{"concept_id": "C4690257", "aliases": [], "types": ["T043"], "canonical_name": "pyrimidine nucleotide-sugar transport"}
{"concept_id": "C4690258", "aliases": [], "types": ["T044"], "canonical_name": "vitamin transporter activity"}
{"concept_id": "C4690259", "aliases": [], "types": ["T043"], "canonical_name": "vacuolar histidine import"}
{"concept_id": "C4690260", "aliases": [], "types": ["T043"], "canonical_name": "lysine transmembrane import into vacuole"}
{"concept_id": "C4690261", "aliases": [], "types": ["T043"], "canonical_name": "vacuolar lysine import"}
{"concept_id": "C4690262", "aliases": [], "types": ["T043"], "canonical_name": "arginine transmembrane import into vacuole"}
{"concept_id": "C4690263", "aliases": [], "types": ["T043"], "canonical_name": "multicellular pellicle formation"}
{"concept_id": "C4690264", "aliases": [], "types": ["T026"], "canonical_name": "integral component of pigment granule membrane", "definition": "The component of the pigment granule membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [PMID:11294610]"}
{"concept_id": "C4690265", "aliases": [], "types": ["T026"], "canonical_name": "pigment granule membrane", "definition": "Any membrane that is part of a pigment granule. [PMID:11294610]"}
{"concept_id": "C4690266", "aliases": [], "types": ["T044"], "canonical_name": "DNMT synthase activity"}
{"concept_id": "C4690267", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of energy homeostasis"}
{"concept_id": "C4690268", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of energy homeostasis"}
{"concept_id": "C4690269", "aliases": [], "types": ["T038"], "canonical_name": "regulation of energy homeostasis"}
{"concept_id": "C4690270", "aliases": [], "types": ["T043"], "canonical_name": "copper ion import across prospore membrane", "definition": "The directed movement of copper ions from outside of a cell, across an ascospore-type prospore membrane and into the cytosol. [GOC:al, GOC:vw, PMID:21828039]"}
{"concept_id": "C4690271", "aliases": ["extrinsic to phagophore assembly site membrane"], "types": ["T026"], "canonical_name": "extrinsic component of phagophore assembly site membrane", "definition": "The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:mf]"}
{"concept_id": "C4690272", "aliases": [], "types": ["T026"], "canonical_name": "phagophore assembly site peripheral membrane"}
{"concept_id": "C4690273", "aliases": [], "types": ["T026"], "canonical_name": "integral to phagophore assembly site membrane"}
{"concept_id": "C4690274", "aliases": [], "types": ["T026"], "canonical_name": "phagophore assembly site integral membrane protein"}
{"concept_id": "C4690275", "aliases": [], "types": ["T044"], "canonical_name": "arginine import"}
{"concept_id": "C4690276", "aliases": [], "types": ["T043"], "canonical_name": "single organismal cell-cell adhesion"}
{"concept_id": "C4690277", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of presynaptic actin cytoskeleton", "definition": "The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton. [GOC:dos]"}
{"concept_id": "C4690278", "aliases": ["high-affinity copper ion transport"], "types": ["T044"], "canonical_name": "high affinity copper ion transport"}
{"concept_id": "C4690279", "aliases": [], "types": ["T043"], "canonical_name": "high affinity copper transport"}
{"concept_id": "C4690280", "aliases": [], "types": ["T044"], "canonical_name": "high affinity glucose import"}
{"concept_id": "C4690281", "aliases": [], "types": ["T043"], "canonical_name": "L-glutamate(1-) import across plasma membrane"}
{"concept_id": "C4690282", "aliases": [], "types": ["T043"], "canonical_name": "pantothenate import"}
{"concept_id": "C4690283", "aliases": [], "types": ["T043"], "canonical_name": "sodium ion import"}
{"concept_id": "C4690284", "aliases": [], "types": ["T044"], "canonical_name": "folate transmembrane transport", "definition": "The process in which a folic acid, or one of its derivatives (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) is transported across a membrane. [PMID:24745983]"}
{"concept_id": "C4690285", "aliases": [], "types": ["T043"], "canonical_name": "folic acid transmembrane transport"}
{"concept_id": "C4690286", "aliases": ["HCN1 channel complex location"], "types": ["T026"], "canonical_name": "HCN1 channel complex"}
{"concept_id": "C4690287", "aliases": ["HCN2 channel complex location"], "types": ["T026"], "canonical_name": "HCN2 channel complex"}
{"concept_id": "C4690288", "aliases": ["HCN3 channel complex location"], "types": ["T026"], "canonical_name": "HCN3 channel complex"}
{"concept_id": "C4690289", "aliases": ["HCN4 channel complex location"], "types": ["T026"], "canonical_name": "HCN4 channel complex"}
{"concept_id": "C4690290", "aliases": ["K/Na hyperpolarization-activated channel 3 complex location"], "types": ["T026"], "canonical_name": "K/Na hyperpolarization-activated channel 3 complex"}
{"concept_id": "C4690291", "aliases": ["K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex location"], "types": ["T026"], "canonical_name": "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex"}
{"concept_id": "C4690292", "aliases": ["K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex location"], "types": ["T026"], "canonical_name": "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex"}
{"concept_id": "C4690293", "aliases": ["K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex location"], "types": ["T026"], "canonical_name": "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex"}
{"concept_id": "C4690294", "aliases": ["potassium/sodium hyperpolarization-activated channel 3 complex location"], "types": ["T026"], "canonical_name": "potassium/sodium hyperpolarization-activated channel 3 complex"}
{"concept_id": "C4690295", "aliases": ["potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex location"], "types": ["T026"], "canonical_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex"}
{"concept_id": "C4690296", "aliases": ["potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex location"], "types": ["T026"], "canonical_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex"}
{"concept_id": "C4690297", "aliases": [], "types": ["T026"], "canonical_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer"}
{"concept_id": "C4690298", "aliases": ["potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex location"], "types": ["T026"], "canonical_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex"}
{"concept_id": "C4690299", "aliases": [], "types": ["T043"], "canonical_name": "presynaptic actin cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. [GOC:dos]"}
{"concept_id": "C4690300", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic actin cytoskeleton", "definition": "The actin cytoskeleton that is part of a presynapse. [GOC:dos]"}
{"concept_id": "C4690301", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of synaptic membrane", "definition": "The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4690302", "aliases": [], "types": ["T043"], "canonical_name": "regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "definition": "Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane. [GOC:dos]"}
{"concept_id": "C4690303", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of postsynaptic density membrane", "definition": "The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4690304", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of postsynaptic density membrane", "definition": "The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]"}
{"concept_id": "C4690305", "aliases": [], "types": ["T039"], "canonical_name": "regulation of synaptic vesicle docking", "definition": "Any process that modulates the frequency, rate or extent of synaptic vesicle docking. [GOC:dos]"}
{"concept_id": "C4690306", "aliases": ["regulation of postsynaptic neurotransmitter receptor endocytosis"], "types": ["T043"], "canonical_name": "regulation of postsynaptic neurotransmitter receptor internalization", "definition": "Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse. [GOC:ai]"}
{"concept_id": "C4690307", "aliases": [], "types": ["T038"], "canonical_name": "regulation of postsynaptic specialization assembly", "definition": "Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization. [GOC:dos]"}
{"concept_id": "C4690308", "aliases": [], "types": ["T038"], "canonical_name": "regulation of postsynaptic density assembly", "definition": "Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density. [GOC:dos]"}
{"concept_id": "C4690309", "aliases": [], "types": ["T043"], "canonical_name": "regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane", "definition": "Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. [GOC:dos, PMID:20098723]"}
{"concept_id": "C4690310", "aliases": ["serotonergic synaptic transmission"], "types": ["T043"], "canonical_name": "synaptic transmission, serotonergic", "definition": "The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, GOC:dph]"}
{"concept_id": "C4690311", "aliases": [], "types": ["T026"], "canonical_name": "serotonergic synapse", "definition": "A synapse that uses serotonin as a neurotransmitter. [GOC:dos]"}
{"concept_id": "C4690312", "aliases": ["noradrenergic synaptic transmission"], "types": ["T043"], "canonical_name": "synaptic transmission, noradrenergic", "definition": "The vesicular release of noradrenaline (norepinephrine) a presynapse, across a chemical synapse, the subsequent activation of noradrenaline receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, GOC:dph]"}
{"concept_id": "C4690313", "aliases": ["exosome mediated"], "types": ["T043"], "canonical_name": "cell-cell signaling via exosome", "definition": "Cell-cell signaling in which the ligand is carried between cells by an exosome. [GOC:dos, PMID:19837038]"}
{"concept_id": "C4690314", "aliases": ["exosome mediated transynaptic signalling"], "types": ["T043"], "canonical_name": "trans-synaptic signalling via exosome", "definition": "Transynaptic signaling in which the ligand is carried across the synapse by an exosome. [GOC:dos, PMID:19837038]"}
{"concept_id": "C4690315", "aliases": [], "types": ["T043"], "canonical_name": "regulation of recycling endosome localization within postsynapse", "definition": "Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse. [GOC:dos, PMID:20098723]"}
{"concept_id": "C4690316", "aliases": ["regulation of postsynapse remodelling"], "types": ["T043"], "canonical_name": "regulation of modification of postsynaptic structure", "definition": "Any process that modulates the frequency, rate or extent of modification of postsynaptic structure. [GOC:dos]"}
{"concept_id": "C4690317", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic intermediate filament cytoskeleton", "definition": "The intermediate filament cytoskeleton that is part of a postsynapse. [GOC:dos, PMID:25869803]"}
{"concept_id": "C4690318", "aliases": ["regulation of presynaptic dense core vesicle exocytosis"], "types": ["T043"], "canonical_name": "regulation of presynaptic dense core granule exocytosis", "definition": "Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis. [GOC:dos, PMID:17881523]"}
{"concept_id": "C4690319", "aliases": ["regulation of neurotransmitter uptake into synaptic vesicle", "regulation of synaptic vesicle neurotransmitter loading"], "types": ["T043"], "canonical_name": "regulation of neurotransmitter loading into synaptic vesicle", "definition": "Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles. [GOC:dos, PMID:25176177]"}
{"concept_id": "C4690320", "aliases": [], "types": ["T043"], "canonical_name": "synaptic signaling by nitric oxide", "definition": "Cell-cell signaling to or from a synapse, mediated by nitric oxide. [GOC:dos, PMID:19038221]"}
{"concept_id": "C4690321", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic specialization membrane of symmetric synapse", "definition": "The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]"}
{"concept_id": "C4690322", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic specialization of symmetric synapse, intracellular component", "definition": "A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses. [GOC:dos]"}
{"concept_id": "C4690323", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic component of postsynaptic specialization membrane of symmetric synapse", "definition": "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos]"}
{"concept_id": "C4690324", "aliases": [], "types": ["T026"], "canonical_name": "intrinsic to postsynaptic specialization membrane of symmetric synapse"}
{"concept_id": "C4690325", "aliases": [], "types": ["T026"], "canonical_name": "integral component of postsynaptic specialization membrane of symmetric synapse", "definition": "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4690326", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of postsynaptic specialization membrane of symmetric synapse", "definition": "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]"}
{"concept_id": "C4690327", "aliases": [], "types": ["T026"], "canonical_name": "anchored component of postsynaptic specialization membrane of symmetric synapse", "definition": "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. [GOC:dos]"}
{"concept_id": "C4690328", "aliases": [], "types": ["T038"], "canonical_name": "postsynaptic modulation of chemical synaptic transmission", "definition": "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. [GOC:dos]"}
{"concept_id": "C4690329", "aliases": [], "types": ["T043"], "canonical_name": "presynaptic modulation of chemical synaptic transmission", "definition": "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. [GOC:dos]"}
{"concept_id": "C4690330", "aliases": ["presynapse organisation", "presynapse development"], "types": ["T043"], "canonical_name": "presynapse organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. [GOC:dos]"}
{"concept_id": "C4690331", "aliases": [], "types": ["T043"], "canonical_name": "presynapse morphogenesis"}
{"concept_id": "C4690332", "aliases": [], "types": ["T043"], "canonical_name": "presynapse organization and biogenesis"}
{"concept_id": "C4690333", "aliases": ["postsynapse organisation", "postsynapse development"], "types": ["T043"], "canonical_name": "postsynapse organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. [GOC:dos]"}
{"concept_id": "C4690334", "aliases": [], "types": ["T043"], "canonical_name": "postsynapse morphogenesis"}
{"concept_id": "C4690335", "aliases": [], "types": ["T043"], "canonical_name": "postsynapse organization and biogenesis"}
{"concept_id": "C4690336", "aliases": ["regulation of presynapse organisation", "regulation of presynapse structure"], "types": ["T038"], "canonical_name": "regulation of presynapse organization", "definition": "Any process that modulates the physical form of a presynapse. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C4690337", "aliases": [], "types": ["T038"], "canonical_name": "regulation of presynapse organization and biogenesis"}
{"concept_id": "C4690338", "aliases": ["regulation of postsynapse structure", "regulation of postsynapse organisation"], "types": ["T038"], "canonical_name": "regulation of postsynapse organization", "definition": "Any process that modulates the physical form of a postsynapse. [GOC:ai, GOC:dph, GOC:tb]"}
{"concept_id": "C4690339", "aliases": [], "types": ["T043"], "canonical_name": "regulation of postsynapse organization and biogenesis"}
{"concept_id": "C4690340", "aliases": [], "types": ["T043"], "canonical_name": "regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex", "definition": "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex. [GOC:dos, PMID:23209303]"}
{"concept_id": "C4690341", "aliases": [], "types": ["T043"], "canonical_name": "regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling"}
{"concept_id": "C4690342", "aliases": [], "types": ["T043"], "canonical_name": "regulation of trans-synaptic signaling", "definition": "Any process that modulates the frequency, rate or extent of trans-synaptic signaling. [GOC:dos]"}
{"concept_id": "C4690343", "aliases": [], "types": ["T043"], "canonical_name": "regulation of retrograde trans-synaptic signaling by endocanabinoid", "definition": "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid. [GOC:dos, PMID:15664177]"}
{"concept_id": "C4690344", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endocannabinoid-mediated retrograde trans-synaptic signaling"}
{"concept_id": "C4690345", "aliases": ["regulation of synapse adhesion between pre- and post-synapse"], "types": ["T043"], "canonical_name": "regulation of synaptic membrane adhesion", "definition": "Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes. [GOC:dos]"}
{"concept_id": "C4690346", "aliases": ["zinc import into synaptic vesicle", "Zn2+ import into synaptic vesicle"], "types": ["T044"], "canonical_name": "zinc ion import into synaptic vesicle", "definition": "The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle. [PMID:9990090]"}
{"concept_id": "C4690347", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of presynapse", "definition": "The action of a molecule that contributes to the structural integrity of a presynapse. [GOC:dos, PMID:23751498]"}
{"concept_id": "C4690348", "aliases": [], "types": ["T026"], "canonical_name": "presynaptic intermediate filament cytoskeleton", "definition": "The intermediate filament cytoskeleton that is part of a presynapse. [GOC:dos]"}
{"concept_id": "C4690349", "aliases": [], "types": ["T043"], "canonical_name": "trans-synaptic signaling by BDNF, modulating synaptic transmission", "definition": "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse. [GOC:dos]"}
{"concept_id": "C4690350", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of postsynaptic intermediate filament cytoskeleton", "definition": "The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton. [GOC:dos]"}
{"concept_id": "C4690351", "aliases": [], "types": ["T043"], "canonical_name": "postsynaptic intermediate filament cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton. [GOC:dos]"}
{"concept_id": "C4690352", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of postsynapse", "definition": "The action of a molecule that contributes to the structural integrity of a postsynapse. [GOC:dos]"}
{"concept_id": "C4690353", "aliases": [], "types": ["T043"], "canonical_name": "presynaptic cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. [GOC:dos]"}
{"concept_id": "C4690354", "aliases": [], "types": ["T043"], "canonical_name": "postsynaptic cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. [GOC:dos]"}
{"concept_id": "C4690355", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic spectrin-associated cytoskeleton", "definition": "The portion of the spectrin-associated cytoskeleton contained within the postsynapse. [GOC:dos, PMID:28576936]"}
{"concept_id": "C4690356", "aliases": [], "types": ["T043"], "canonical_name": "postsynaptic spectrin-associated cytoskeleton organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse. [GOC:dos, PMID:28576936]"}
{"concept_id": "C4690357", "aliases": ["trans-synaptic signaling by brain-derived neurotrophic factor"], "types": ["T043"], "canonical_name": "trans-synaptic signaling by BDNF", "definition": "Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft. [GOC:dos]"}
{"concept_id": "C4690358", "aliases": [], "types": ["T026"], "canonical_name": "cerebellar Golgi cell to granule cell synapse", "definition": "A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell. [PMID:26134650]"}
{"concept_id": "C4690359", "aliases": ["intrinsic to synaptic membrane"], "types": ["T026"], "canonical_name": "intrinsic component of synaptic membrane", "definition": "The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]"}
{"concept_id": "C4690360", "aliases": [], "types": ["T026"], "canonical_name": "extrinsic component of synaptic membrane", "definition": "The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]"}
{"concept_id": "C4690361", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to spore cell wall", "definition": "A process in which a protein is transported, tethered to or otherwise maintained in a spore cell wall. [GOC:dos]"}
{"concept_id": "C4690362", "aliases": [], "types": ["T026"], "canonical_name": "integral component of synaptic membrane", "definition": "The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos]"}
{"concept_id": "C4690363", "aliases": [], "types": ["T044"], "canonical_name": "phosphohistidine phosphatase activity"}
{"concept_id": "C4690366", "aliases": [], "types": ["T044"], "canonical_name": "thiosulfate transmembrane-transporting ATPase activity"}
{"concept_id": "C4690367", "aliases": [], "types": ["T044"], "canonical_name": "cystathionine gamma-synthase activity (acts on O-phosphohomoserine)", "definition": "Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate. [GOC:pz, PMID:5922970, PMID:9531508]"}
{"concept_id": "C4690368", "aliases": [], "types": ["T044"], "canonical_name": "fumarate reductase (menaquinone)", "definition": "Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone. [GOC:pz, PMID:11850430, RHEA:27834]"}
{"concept_id": "C4690369", "aliases": [], "types": ["T044"], "canonical_name": "7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase", "definition": "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid. [GOC:pz, RHEA:35951]"}
{"concept_id": "C4690370", "aliases": [], "types": ["T044"], "canonical_name": "dehydroquinate synthase activity", "definition": "Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+. [GOC:pz, RHEA:25956]"}
{"concept_id": "C4690371", "aliases": [], "types": ["T044"], "canonical_name": "alpha-patchoulene synthase activityy", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + alpha-patchoulene. [EC:4.2.3.-, GOC:pz]"}
{"concept_id": "C4690372", "aliases": [], "types": ["T044"], "canonical_name": "dehydroscoulerine synthase activity", "definition": "Catalysis of the reaction: (S)-scoulerine + O2 = dehydroscoulerine + hydrogen peroxide + H+. [EC:1.21.3.-, GOC:pz]"}
{"concept_id": "C4690373", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-5-phosphate 5-phosphatase activity", "definition": "Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = hydrogenphosphate + an L-1-phosphatidyl-inositol. [EC:3.1.3.-, GOC:pz]"}
{"concept_id": "C4690374", "aliases": [], "types": ["T044"], "canonical_name": "5-diphosphoinositol pentakisphosphate 3-kinase activity", "definition": "Catalysis of the reaction: 5-diphospho-1D-myo-inositol pentakisphosphate + ATP = 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP. [EC:2.7.4.24, GOC:pz]"}
{"concept_id": "C4690375", "aliases": [], "types": ["T044"], "canonical_name": "D-galacturonate reductase activity", "definition": "Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+. [EC:1.1.1.365, GOC:pz]"}
{"concept_id": "C4690376", "aliases": [], "types": ["T044"], "canonical_name": "homocarnosine synthase activity", "definition": "Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate. [EC:6.3.2.11, GOC:pz]"}
{"concept_id": "C4690377", "aliases": [], "types": ["T044"], "canonical_name": "demethoxycurcumin synthase activity from feruloylacetyl-CoA", "definition": "Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide. [GOC:pz, RHEA:35139]"}
{"concept_id": "C4690378", "aliases": [], "types": ["T044"], "canonical_name": "hypoxia-inducible factor-asparagine oxygenase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + O2 + a hypoxia inducible factor (HIF) alpha subunit = succinate + carbon dioxide + a (3S)-3-hydroxy-L-asparagine-HIF alpha subunit. [GOC:pz, RHEA:54268]"}
{"concept_id": "C4690379", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan asparagine synthase activity", "definition": "Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid. [EC:6.3.1.-, GOC:pz]"}
{"concept_id": "C4690380", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A34 carboxyl methyltransferase activity", "definition": "Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz, RHEA:36127]"}
{"concept_id": "C4690381", "aliases": [], "types": ["T044"], "canonical_name": "chalcone synthase activity", "definition": "Catalysis of the reaction: 4-dihydrocoumaroyl-CoA + 3 malonyl-CoA + 3 H+ = phloretin + 4 coenzyme A + 3 carbon dioxide. [GOC:pz, PMID:20356611]"}
{"concept_id": "C4690382", "aliases": [], "types": ["T044"], "canonical_name": "heparan sulfate N-deacetylase activity", "definition": "Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine. [EC:3.1.1.-, GOC:pz]"}
{"concept_id": "C4690383", "aliases": [], "types": ["T044"], "canonical_name": "[chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity", "definition": "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate. [EC:2.8.2.-, GOC:pz]"}
{"concept_id": "C4690384", "aliases": [], "types": ["T044"], "canonical_name": "tricetin O-methytransferase activity", "definition": "Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine. [GOC:pz, RHEA:27493]"}
{"concept_id": "C4690385", "aliases": [], "types": ["T044"], "canonical_name": "3'-O-methyltricetin O methyl transferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4690386", "aliases": [], "types": ["T044"], "canonical_name": "N-acetyl-beta-D-galactosaminidase activity", "definition": "Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan. [EC:3.2.1.52, GOC:pz]"}
{"concept_id": "C4690387", "aliases": [], "types": ["T044"], "canonical_name": "very-long-chain 3-hydroxyacyl-CoA dehydratase activity", "definition": "Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain trans-2,3-dehydroacyl-CoA. [GOC:pz, RHEA:45812]"}
{"concept_id": "C4690388", "aliases": [], "types": ["T044"], "canonical_name": "3-hydroxyacyl-CoA-acyl carrier protein transferase activity", "definition": "Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690389", "aliases": [], "types": ["T044"], "canonical_name": "L-idonate 5-dehydrogenase activity (NAD-dependent)", "definition": "Catalysis of the reaction: L-idonate + NAD = 5-dehydro-D-gluconate + NADH + H+. [GOC:pz, RHEA:21172]"}
{"concept_id": "C4690390", "aliases": [], "types": ["T044"], "canonical_name": "nitric oxide reductase activity (NAD(P)H-dependent) activity", "definition": "Catalysis of the reaction: dinitrogen oxide + H2O + NAD(P) = 2 nitric oxide + H+ + NAD(P)H. [EC:1.7.1.14, GOC:pz]"}
{"concept_id": "C4690391", "aliases": [], "types": ["T044"], "canonical_name": "N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity", "definition": "Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate. [GOC:pz, RHEA:33159]"}
{"concept_id": "C4690392", "aliases": ["cholesterol allpha-glucosyltransferase activity"], "types": ["T044"], "canonical_name": "cholesterol alpha-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+. [GOC:pz, RHEA:61848]"}
{"concept_id": "C4690393", "aliases": ["behenate omega-hydroxylase activity"], "types": ["T044"], "canonical_name": "docosanoate omega-hydroxylase activity", "definition": "Catalysis of the reaction: docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:krc, GOC:pz, RHEA:40079]"}
{"concept_id": "C4690394", "aliases": [], "types": ["T044"], "canonical_name": "unsaturated chondroitin disaccharide hydrolase activity", "definition": "Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate. [EC:3.2.1.180, GOC:pz]"}
{"concept_id": "C4690395", "aliases": [], "types": ["T044"], "canonical_name": "in-chain hydroxy fatty acyl-CoA synthetase activity", "definition": "Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA. [EC:6.2.1.-, GOC:pz]"}
{"concept_id": "C4690396", "aliases": [], "types": ["T044"], "canonical_name": "omega-hydroxy fatty acyl-CoA synthetase activity", "definition": "Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA. [EC:6.2.1.-, GOC:pz]"}
{"concept_id": "C4690397", "aliases": [], "types": ["T044"], "canonical_name": "maltodextrin water dikinase", "definition": "Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin. [EC:2.7.9.4, GOC:pz]"}
{"concept_id": "C4690398", "aliases": [], "types": ["T044"], "canonical_name": "6-phosphoglucan, water dikinase activity", "definition": "Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin. [GOC:pz, RHEA:10256]"}
{"concept_id": "C4690399", "aliases": [], "types": ["T044"], "canonical_name": "starch, H2O dikinase activity", "definition": "Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin. [EC:2.7.9.4, GOC:pz]"}
{"concept_id": "C4690400", "aliases": [], "types": ["T044"], "canonical_name": "phosphogluco-amylopectin water dikinase activity", "definition": "Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin. [EC:2.7.9.5, GOC:pz]"}
{"concept_id": "C4690401", "aliases": [], "types": ["T044"], "canonical_name": "hydrogenase activity (NAD+, ferredoxin)", "definition": "Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin. [GOC:pz, RHEA:30279]"}
{"concept_id": "C4690402", "aliases": [], "types": ["T044"], "canonical_name": "geraniol kinase activity (ATP-dependent) activity", "definition": "Catalysis of the reaction: geraniol + ATP = geranyl monophosphate + ADP + H+. [EC:2.7.1.-, GOC:pz]"}
{"concept_id": "C4690403", "aliases": [], "types": ["T044"], "canonical_name": "ATP:geranylgeraniol phosphotransferase activity", "definition": "Catalysis of the reaction: (E,E)-geranylgeraniol + ATP = H+ + all-trans-geranyl-geranyl monophosphate + ADP. [GOC:pz, RHEA:61660]"}
{"concept_id": "C4690404", "aliases": [], "types": ["T044"], "canonical_name": "diacylglycerol transacylase activity", "definition": "Catalysis of the reaction: 2 a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + a 2-monoglyceride. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690405", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylcholine:diacylglycerol cholinephosphotransferase activity", "definition": "Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine. [EC:2.7.8.-, GOC:pz]"}
{"concept_id": "C4690406", "aliases": [], "types": ["T044"], "canonical_name": "linear malto-oligosaccharide phosphorylase activity", "definition": "Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide. [EC:2.4.1.1, GOC:pz]"}
{"concept_id": "C4690407", "aliases": [], "types": ["T044"], "canonical_name": "cellulose 1,4-beta-cellobiosidase activity (reducing end)", "definition": "Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains. [EC:3.2.1.176, GOC:pz]"}
{"concept_id": "C4690408", "aliases": [], "types": ["T044"], "canonical_name": "1,3-diacylglycerol acylhydrolase activity", "definition": "Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid. [GOC:pz, PMID:21477884]"}
{"concept_id": "C4690409", "aliases": [], "types": ["T044"], "canonical_name": "1,2-diacylglycerol acylhydrolase activity", "definition": "Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid. [GOC:pz, PMID:1477884]"}
{"concept_id": "C4690410", "aliases": [], "types": ["T044"], "canonical_name": "homophytochelatin synthase activity (polymer-forming)", "definition": "Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine. [EC:2.3.2.-, GOC:pz]"}
{"concept_id": "C4690411", "aliases": [], "types": ["T044"], "canonical_name": "2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity", "definition": "Catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine. [EC:3.2.1.-, GOC:pz]"}
{"concept_id": "C4690412", "aliases": [], "types": ["T044"], "canonical_name": "choline monooxygenase activity (NADP-dependent)", "definition": "Catalysis of the reaction: choline + NADP = betaine aldehyde + NADPH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4690413", "aliases": [], "types": ["T044"], "canonical_name": "1-deoxy-11-oxopentalenate oxygenase activity", "definition": "Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP. [GOC:pz, RHEA:34635]"}
{"concept_id": "C4690414", "aliases": [], "types": ["T044"], "canonical_name": "ornithine N-delta-acetyltransferase activity", "definition": "Catalysis of the reaction: L-ornithinium(1+) = N(5)-acetyl-L-ornithine. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690415", "aliases": [], "types": ["T044"], "canonical_name": "11alpha-hydroxy-beta-amyrin dehydrogenase activity", "definition": "Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP. [GOC:pz, RHEA:31719]"}
{"concept_id": "C4690416", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol dehydrogenase activity", "definition": "Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+. [GOC:pz, RHEA:35459]"}
{"concept_id": "C4690417", "aliases": [], "types": ["T044"], "canonical_name": "selenocystathione synthase activity", "definition": "Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine. [EC:2.5.1.-, GOC:pz]"}
{"concept_id": "C4690418", "aliases": [], "types": ["T044"], "canonical_name": "linoleate 9R-lipoxygenase activity", "definition": "Catalysis of the reaction: linoleate + O2 = 9(R)-HPODE. [GOC:pz, RHEA:31691]"}
{"concept_id": "C4690419", "aliases": [], "types": ["T044"], "canonical_name": "gamma-linolenate elongase activity", "definition": "Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690421", "aliases": [], "types": ["T044"], "canonical_name": "2-propylphenol monooxygenase activity", "definition": "Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD. [GOC:pz]"}
{"concept_id": "C4690422", "aliases": [], "types": ["T044"], "canonical_name": "2-isopropylphenol monooxygenase activity", "definition": "Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD. [GOC:pz, RHEA:63520]"}
{"concept_id": "C4690423", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+. [EC:3.7.1.-, GOC:pz]"}
{"concept_id": "C4690424", "aliases": [], "types": ["T044"], "canonical_name": "3-oxoacyl-CoA hydrolase activity", "definition": "Catalysis of the reaction: H2O + a 3-oxoacyl-CoA = H+ + coenzyme A + a 3-oxoacid. [EC:3.1.2.-, GOC:pz]"}
{"concept_id": "C4690425", "aliases": [], "types": ["T044"], "canonical_name": "3-oxoacid decarboxylase activity", "definition": "Catalysis of the reaction: H+ + a 3-oxoacid = carbon dioxide + a methylketone. [EC:4.1.1.-, GOC:pz]"}
{"concept_id": "C4690426", "aliases": [], "types": ["T044"], "canonical_name": "palmitoyl-[acp] elongase/decarboxylase activity", "definition": "Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690427", "aliases": [], "types": ["T044"], "canonical_name": "heptadecanoyl-[acp] elongase/decarboxylase activity", "definition": "Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690428", "aliases": [], "types": ["T044"], "canonical_name": "fatty-acyl-[acp] elongase/decarboxylase activity", "definition": "Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690429", "aliases": [], "types": ["T044"], "canonical_name": "stearoyl-[acp] elongase/decarboxylase activity", "definition": "Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690430", "aliases": [], "types": ["T044"], "canonical_name": "gamma-aminobutyrate transaminase (glyoxylate dependent) activity", "definition": "Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine. [EC:2.6.1.96, GOC:pz]"}
{"concept_id": "C4690431", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidate kinase activity", "definition": "Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate. [EC:2.7.4.-, GOC:pz]"}
{"concept_id": "C4690432", "aliases": [], "types": ["T044"], "canonical_name": "11-cis-retinol dehydrogenase activity", "definition": "Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+. [GOC:pz, RHEA:54912]"}
{"concept_id": "C4690433", "aliases": [], "types": ["T044"], "canonical_name": "taxusin 2-alpha-hydroxylase activity", "definition": "Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O. [GOC:pz, PMID:15178487]"}
{"concept_id": "C4690434", "aliases": [], "types": ["T044"], "canonical_name": "7-beta-hydroxytaxusin 2-alpha-hydroxylase activity", "definition": "Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4690435", "aliases": [], "types": ["T044"], "canonical_name": "steviol 13-O glucosyltransferase activity", "definition": "Catalysis of the reaction: steviol + UDP-alpha-D-glucose = steviolmonoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690436", "aliases": [], "types": ["T044"], "canonical_name": "steviolmonoside glucosyltransferase activity", "definition": "Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690437", "aliases": [], "types": ["T044"], "canonical_name": "steviolbioside glucosyltransferase activity (stevioside forming)", "definition": "Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690438", "aliases": [], "types": ["T044"], "canonical_name": "steviolbioside glucosyltransferase activity (rebaudioside B forming)", "definition": "Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = rebaudioside B + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690439", "aliases": [], "types": ["T044"], "canonical_name": "stevioside glucosyltransferase activity (rebaudioside A forming)", "definition": "Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = rebaudioside A + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690440", "aliases": [], "types": ["T044"], "canonical_name": "phenylacetaldehyde reductase activity", "definition": "Catalysis of the reaction: 2-phenylethanol + NADP = phenylacetaldehyde + NADPH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4690441", "aliases": [], "types": ["T044"], "canonical_name": "2-phenylethanol acetyltransferase activity", "definition": "Catalysis of the reaction: 2-phenylethanol + acetyl-CoA = phenethyl acetate + coenzyme A. [EC:2.3.1.224, GOC:pz]"}
{"concept_id": "C4690442", "aliases": [], "types": ["T044"], "canonical_name": "polyprenol reductase activity", "definition": "Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol. [EC:1.3.1.94, GOC:pz]"}
{"concept_id": "C4690443", "aliases": [], "types": ["T044"], "canonical_name": "2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "definition": "Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose. [EC:3.2.1.149, GOC:pz]"}
{"concept_id": "C4690444", "aliases": [], "types": ["T044"], "canonical_name": "luteolin-7-O-glucoside 1,6-glucosyltransferase activity", "definition": "Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690445", "aliases": [], "types": ["T044"], "canonical_name": "sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity", "definition": "Catalysis of the reaction: omega-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-omega-hydroxy-C22:0-LPA. [EC:2.3.1.198, GOC:pz]"}
{"concept_id": "C4690446", "aliases": [], "types": ["T044"], "canonical_name": "sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity", "definition": "Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate. [EC:2.3.1.15, GOC:pz]"}
{"concept_id": "C4690447", "aliases": [], "types": ["T044"], "canonical_name": "alpha-linolenate delta5 desaturase activity", "definition": "Catalysis of the reaction: alpha-linolenate + O2 + a reduced electron acceptor = coniferonate + 2 H2O + an oxidized electron acceptor. [EC:1.14.19.-, GOC:pz]"}
{"concept_id": "C4690448", "aliases": [], "types": ["T044"], "canonical_name": "linoleate delta5 desaturase activity"}
{"concept_id": "C4690449", "aliases": [], "types": ["T044"], "canonical_name": "anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity", "definition": "Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]. [GOC:pz, RHEA:35411]"}
{"concept_id": "C4690450", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 3-O-galactosyltransferase activity", "definition": "Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP. [GOC:pz, RHEA:35631]"}
{"concept_id": "C4690451", "aliases": [], "types": ["T044"], "canonical_name": "anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + an anthocyanidin-3-O-beta-D-glucoside = UDP + H+ + an anthocyanidin 3-O-sophoroside. [GOC:pz, RHEA:35419]"}
{"concept_id": "C4690452", "aliases": [], "types": ["T044"], "canonical_name": "8-oxo-deoxyadenine diphosphate phosphatase activity", "definition": "Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+. [EC:3.6.1.-, GOC:pz]"}
{"concept_id": "C4690453", "aliases": [], "types": ["T044"], "canonical_name": "kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690454", "aliases": [], "types": ["T044"], "canonical_name": "beta-carotene 2,2'-beta-hydroxylase activity", "definition": "Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4690455", "aliases": [], "types": ["T044"], "canonical_name": "beta-L-arabinofuranosidase activity", "definition": "Catalysis of the reaction: beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose. [GOC:pz, RHEA:36051]"}
{"concept_id": "C4690456", "aliases": [], "types": ["T044"], "canonical_name": "5-deoxy-D-glucuronate isomerase activity", "definition": "Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate. [GOC:pz, RHEA:25840]"}
{"concept_id": "C4690457", "aliases": [], "types": ["T044"], "canonical_name": "dATP phosphohydrolase activity", "definition": "Catalysis of the reaction: dATP + 2 H2O = dAMP + 2 hydrogenphosphate + 2 H+. [EC:3.6.1.5, GOC:pz]"}
{"concept_id": "C4690458", "aliases": [], "types": ["T044"], "canonical_name": "dCTP phosphohydrolase activity", "definition": "Catalysis of the reaction: dCTP + 2 H2O = dCMP + 2 hydrogenphosphate + 2 H+. [EC:3.6.1.5, GOC:pz]"}
{"concept_id": "C4690459", "aliases": [], "types": ["T044"], "canonical_name": "dUTP phosphohydrolase activity", "definition": "Catalysis of the reaction: dUTP + 2 H2O = dUMP + 2 hydrogenphosphate + 2 H+. [EC:3.6.1.5, GOC:pz]"}
{"concept_id": "C4690460", "aliases": [], "types": ["T044"], "canonical_name": "dTTP phosphohydrolase activity", "definition": "Catalysis of the reaction: dTTP + 2 H2O = dTMP + 2 hydrogenphosphate + 2 H+. [EC:3.6.1.5, GOC:pz]"}
{"concept_id": "C4690461", "aliases": [], "types": ["T044"], "canonical_name": "GTP phosphohydrolase activity", "definition": "Catalysis of the reaction: GTP + 2 H2O = GMP + 2 hydrogenphosphate + 2 H+. [EC:3.6.1.5, GOC:pz]"}
{"concept_id": "C4690462", "aliases": [], "types": ["T044"], "canonical_name": "dGTP phosphohydrolase activity", "definition": "Catalysis of the reaction: dGTP + 2 H2O = dGMP + 2 hydrogenphosphate + 2 H+. [EC:3.6.1.5, GOC:pz]"}
{"concept_id": "C4690463", "aliases": [], "types": ["T044"], "canonical_name": "maltose glucosidase activity", "definition": "Catalysis of the reaction: H2O + maltose = 2 glucose. [GOC:pz, PMID:16343940]"}
{"concept_id": "C4690464", "aliases": [], "types": ["T044"], "canonical_name": "SHG alpha-glucan phosphorylase activity", "definition": "Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan. [GOC:pz, RHEA:41732]"}
{"concept_id": "C4690465", "aliases": [], "types": ["T044"], "canonical_name": "beta-maltose 4-alpha-glucanotransferase activity", "definition": "Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose. [EC:2.4.1.25, GOC:pz]"}
{"concept_id": "C4690466", "aliases": [], "types": ["T044"], "canonical_name": "D-fructuronate reductase activity", "definition": "Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate. [GOC:pz, PMID:22925190]"}
{"concept_id": "C4690467", "aliases": [], "types": ["T044"], "canonical_name": "ADP-glucose-starch glucosyltransferase activity", "definition": "Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose. [EC:2.4.1.242, GOC:pz]"}
{"concept_id": "C4690468", "aliases": [], "types": ["T044"], "canonical_name": "oleate 12-hydroxylase activity", "definition": "Catalysis of the reaction: oleoyl-CoA + NADH + O2 + H+ = ricinoleyl-CoA + NAD + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4690469", "aliases": [], "types": ["T044"], "canonical_name": "(11Z)-eicosenoate 14-hydroxylase activity", "definition": "Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O. [EC:1.14.18.4, GOC:pz, PMID:8784737, PMID:9680976]"}
{"concept_id": "C4690470", "aliases": [], "types": ["T044"], "canonical_name": "L-threonine O-3-phosphate phosphatase activity", "definition": "Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate. [EC:3.1.3.-, GOC:pz]"}
{"concept_id": "C4690471", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-4-demethylwyosine synthase activity", "definition": "Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe. [GOC:pz, PMID:34184886, RHEA:36347]"}
{"concept_id": "C4690472", "aliases": [], "types": ["T044"], "canonical_name": "tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe. [GOC:pz, RHEA:37899]"}
{"concept_id": "C4690473", "aliases": [], "types": ["T044"], "canonical_name": "2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity", "definition": "Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide. [GOC:pz, RHEA:36607]"}
{"concept_id": "C4690474", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H. [GOC:pz, PMID:10627048, PMID:24817117]"}
{"concept_id": "C4690475", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H. [GOC:pz, PMID:10627048]"}
{"concept_id": "C4690476", "aliases": [], "types": ["T044"], "canonical_name": "D-mannose 6-phosphate 1-epimerase activity", "definition": "Catalysis of the reaction: alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate. [EC:5.1.3.-, GOC:pz]"}
{"concept_id": "C4690477", "aliases": [], "types": ["T044"], "canonical_name": "D-galactose 6-phosphate 1-epimerase activity", "definition": "Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate. [EC:5.1.3.-, GOC:pz]"}
{"concept_id": "C4690478", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidyl phospholipase B activity", "definition": "Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate. [EC:3.1.1.5, GOC:pz]"}
{"concept_id": "C4690479", "aliases": [], "types": ["T044"], "canonical_name": "lipoyl synthase activity (acting on glycine-cleavage complex H protein", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. [EC:2.8.1.8, GOC:pz]"}
{"concept_id": "C4690480", "aliases": [], "types": ["T044"], "canonical_name": "lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. [EC:2.8.1.8, GOC:pz]"}
{"concept_id": "C4690481", "aliases": [], "types": ["T044"], "canonical_name": "lipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. [EC:2.8.1.8, GOC:pz]"}
{"concept_id": "C4690483", "aliases": [], "types": ["T044"], "canonical_name": "protein-(glutamine-N5) methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine. [GOC:pz, RHEA:42896]"}
{"concept_id": "C4690484", "aliases": [], "types": ["T044"], "canonical_name": "hydroxyproline O-arbinofuranose transferase activity", "definition": "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline. [EC:2.4.2.-, GOC:pz]"}
{"concept_id": "C4690485", "aliases": [], "types": ["T044"], "canonical_name": "1-acyl dihydroxyacetone phosphate reductase activity", "definition": "Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP. [EC:1.1.1.101, GOC:pz]"}
{"concept_id": "C4690488", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine:phenylpyruvate aminotransferase activity", "definition": "Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate. [EC:2.6.1.-, GOC:pz]"}
{"concept_id": "C4690489", "aliases": [], "types": ["T044"], "canonical_name": "N-glutamylanilide hydrolase activity", "definition": "Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+. [EC:3.5.1.-, GOC:pz]"}
{"concept_id": "C4690490", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-myristoyl-ACP hydrolase activity", "definition": "Catalysis of the reaction: H2O + a 3-oxo-myristoyl-[acp] = 3-oxo-myristate + H+ + a holo-[acyl-carrier protein]. [EC:3.1.2.-, GOC:pz]"}
{"concept_id": "C4690491", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-dodecanoyl-ACP hydrolase activity", "definition": "Catalysis of the reaction: H2O + a 3-oxo-dodecanoyl-[acp] = 3-oxododecanoate + H+ + a holo-[acyl-carrier protein]. [EC:3.1.2.-, GOC:pz]"}
{"concept_id": "C4690492", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-palmitoyl-ACP hydrolase activity", "definition": "Catalysis of the reaction: H2O + a 3-oxo-palmitoyl-[acp] = 3-oxopalmitic acid + H+ + a holo-[acyl-carrier protein]. [EC:3.1.2.-, GOC:pz]"}
{"concept_id": "C4690493", "aliases": [], "types": ["T044"], "canonical_name": "3-oxo-palmitate decarboxylase activity", "definition": "Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide. [EC:4.1.1.56, GOC:pz]"}
{"concept_id": "C4690494", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose: N-methylanthranilate glucosyltransferase activity", "definition": "Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690495", "aliases": [], "types": ["T044"], "canonical_name": "3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity", "definition": "Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4690496", "aliases": [], "types": ["T044"], "canonical_name": "[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity", "definition": "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid. [EC:2.5.1.105, GOC:pz]"}
{"concept_id": "C4690497", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity", "definition": "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, PMID:15579662]"}
{"concept_id": "C4690498", "aliases": [], "types": ["T044"], "canonical_name": "isopentenyladenine UDP glycosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 9-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690499", "aliases": [], "types": ["T044"], "canonical_name": "cis-zeatin UDP glycosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + 9-(alpha-D-glucosyl)-cis-zeatin + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690500", "aliases": [], "types": ["T044"], "canonical_name": "trans-zeatin-O-glucoside UDP glycosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690501", "aliases": [], "types": ["T044"], "canonical_name": "butein:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+. [GOC:pz, RHEA:34203]"}
{"concept_id": "C4690502", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity", "definition": "Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine. [EC:2.1.1.49, GOC:pz]"}
{"concept_id": "C4690503", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity", "definition": "Catalysis of the reaction: N-methyl-beta-alanine + S-adenosyl-L-methionine = H+ + N,N-dimethyl-beta-alanine + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4690504", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity", "definition": "Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4690505", "aliases": [], "types": ["T044"], "canonical_name": "D-inositol-3-phosphate glycosyltransferase activity", "definition": "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+. [GOC:pz, RHEA:26188]"}
{"concept_id": "C4690506", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosyl-L-methionine:eugenol-O-methyltransferase activity", "definition": "Catalysis of the reaction: eugenol + S-adenosyl-L-methionine = H+ + O-methyleugenol + S-adenosyl-L-homocysteine. [EC:2.1.1.146, GOC:pz]"}
{"concept_id": "C4690507", "aliases": [], "types": ["T044"], "canonical_name": "acetyl-coenzyme A:acetyl alcohol acetyltransferase activity", "definition": "Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A. [EC:2.3.1.224, GOC:pz]"}
{"concept_id": "C4690508", "aliases": [], "types": ["T044"], "canonical_name": "ubiquinol:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone. [GOC:pz, RHEA:30255]"}
{"concept_id": "C4690509", "aliases": [], "types": ["T044"], "canonical_name": "gamma-hydroxybutyrate dehydrogenase activity (NAD(P)-dependent", "definition": "Catalysis of the reaction: 4-hydroxybutyrate + NAD(P) = 4-oxobutanoate + H+ + NAD(P)H. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4690510", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:curcumin glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + curcumin = curcumin monoglucoside + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690511", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:curcumin monoglucoside glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + curcumin monoglucoside = H+ + curcumin diglucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690512", "aliases": [], "types": ["T044"], "canonical_name": "24-methyldesmosterol reductase activity", "definition": "Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP. [EC:1.3.-.-, GOC:pz]"}
{"concept_id": "C4690513", "aliases": [], "types": ["T044"], "canonical_name": "DIMBOA glucoside beta-D-glucosidase activity", "definition": "Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose. [EC:3.2.1.182, GOC:pz]"}
{"concept_id": "C4690514", "aliases": [], "types": ["T044"], "canonical_name": "3beta-hydroxysteroid dehydrogenase activity", "definition": "Catalysis of the reaction: campest-4-en-3beta-ol + NAD = campest-4-en-3-one + NADH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4690515", "aliases": [], "types": ["T044"], "canonical_name": "campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity", "definition": "Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4690516", "aliases": [], "types": ["T044"], "canonical_name": "6-oxocampestanol hydroxylase activity", "definition": "Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4690517", "aliases": [], "types": ["T044"], "canonical_name": "D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity", "definition": "Catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP. [EC:2.7.1.-, GOC:pz]"}
{"concept_id": "C4690518", "aliases": [], "types": ["T044"], "canonical_name": "myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity", "definition": "Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP. [EC:2.7.1.140, GOC:pz]"}
{"concept_id": "C4690519", "aliases": [], "types": ["T044"], "canonical_name": "typhasterol C-23 hydroxylase activity", "definition": "Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor. [GOC:pz, PMID:17138693]"}
{"concept_id": "C4690520", "aliases": [], "types": ["T044"], "canonical_name": "trihydroxybenzophenone synthase activity", "definition": "Catalysis of the reaction: benzoyl-CoA + 3 malonyl-CoA + 3 H+ = 2,4,6-trihydroxybenzophenone + 4 coenzyme A + 3 carbon dioxide. [GOC:pz, RHEA:35143]"}
{"concept_id": "C4690521", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-geranyl-geranyl diphosphate reductase activity", "definition": "Catalysis of the reaction: H+ + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + NADPH = dihydrogeranylgeranyl-PP + NADP. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4690522", "aliases": [], "types": ["T044"], "canonical_name": "dihydrogeranylgeranyl-PP reductase activity", "definition": "Catalysis of the reaction: H+ + dihydrogeranylgeranyl-PP + NADPH = tetrahydrogeranylgeranyl-PP + NADP. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4690523", "aliases": [], "types": ["T044"], "canonical_name": "tetrahydrogeranylgeranyl-PP reductase activity", "definition": "Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4690524", "aliases": [], "types": ["T044"], "canonical_name": "geranylgeranyl-chlorophyll a reductase activity", "definition": "Catalysis of the reaction: H+ + geranylgeranyl-chlorophyll a + NADPH = dihydrogeranylgeranyl-chlorophyll a + NADP. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4690525", "aliases": [], "types": ["T044"], "canonical_name": "dihydrogeranylgeranyl-chlorophyll a reductase activity", "definition": "Catalysis of the reaction: H+ + dihydrogeranylgeranyl-chlorophyll a + NADPH = tetrahydrogeranylgeranyl-chlorophyll a + NADP. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4690526", "aliases": [], "types": ["T044"], "canonical_name": "tetrahydrogeranylgeranyl-chlorophyll a reductase activity", "definition": "Catalysis of the reaction: chlorophyll a + NADP = tetrahydrogeranylgeranyl-chlorophyll a + NADPH + H+. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4690527", "aliases": [], "types": ["T044"], "canonical_name": "UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+. [EC:2.4.1.186, GOC:pz]"}
{"concept_id": "C4690528", "aliases": [], "types": ["T044"], "canonical_name": "1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)", "definition": "Catalysis of the reaction: a glucosylated glycogenin = a glycogen. [EC:2.4.1.18, GOC:pz]"}
{"concept_id": "C4690529", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity", "definition": "Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4690530", "aliases": [], "types": ["T044"], "canonical_name": "very-long-chain 3-ketoacyl-CoA synthase activity", "definition": "Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA. [GOC:pz, RHEA:32727]"}
{"concept_id": "C4690531", "aliases": [], "types": ["T044"], "canonical_name": "NADPH phosphatase activity", "definition": "Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate. [EC:3.1.3.-, GOC:pz]"}
{"concept_id": "C4690532", "aliases": [], "types": ["T044"], "canonical_name": "very-long-chain enoyl-CoA reductase activity", "definition": "Catalysis of the reaction: NADP(3-) + a very-long-chain 2,3,4-saturated fatty acyl CoA <=> NADPH(4-) + H+ + a very-long-chain trans-2,3-dehydroacyl-CoA. [EC:1.3.1.93, GOC:pz]"}
{"concept_id": "C4690533", "aliases": [], "types": ["T044"], "canonical_name": "6-deoxotyphasterol C-23 hydroxylase activity", "definition": "Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor. [EC:1.14.-.-, GOC:pz]"}
{"concept_id": "C4690534", "aliases": [], "types": ["T044"], "canonical_name": "UDP-D-apiose synthase activity", "definition": "Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = UDP-alpha-D-apiose + carbon dioxide. [EC:4.1.1.-, GOC:pz]"}
{"concept_id": "C4690535", "aliases": [], "types": ["T044"], "canonical_name": "flavanone 4'-O-methyltransferase activity", "definition": "Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine. [EC:2.1.1.231, GOC:pz]"}
{"concept_id": "C4690536", "aliases": [], "types": ["T044"], "canonical_name": "dihydroceramide glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine. [EC:2.4.1.80, GOC:pz]"}
{"concept_id": "C4690537", "aliases": [], "types": ["T044"], "canonical_name": "inositol phosphorylceramide synthase activity", "definition": "Catalysis of the reaction: an L-1-phosphatidyl-inositol + a dihydroceramide = an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol. [EC:2.7.1.-, GOC:pz]"}
{"concept_id": "C4690538", "aliases": [], "types": ["T044"], "canonical_name": "sphingolipid very long chain fatty acid alpha-hydroxylase activity", "definition": "Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4690539", "aliases": [], "types": ["T044"], "canonical_name": "sphingolipid long-chain base 4-hydroxylase activity", "definition": "Catalysis of the reaction: O2 + H+ + a dihydroceramide + NAD(P)H = H2O + a phytoceramide + NAD(P). [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4690540", "aliases": [], "types": ["T044"], "canonical_name": "dihydroceramide kinase activity", "definition": "Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate. [EC:2.7.1.138, GOC:pz]"}
{"concept_id": "C4690541", "aliases": [], "types": ["T044"], "canonical_name": "6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity", "definition": "Catalysis of the reaction: 2 H+ + isovaleryl-CoA + 3 malonyl-CoA = 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone + 4 coenzyme A + 3 carbon dioxide. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690542", "aliases": [], "types": ["T044"], "canonical_name": "cholestanol hydroxylase activity", "definition": "Catalysis of the reaction: H+ + epidihydrocholesterin + O2 + NADPH = (22alpha)-hydroxy-cholestanol + H2O + NADP. [EC:1.14.13.-, GOC:pz]"}
{"concept_id": "C4690543", "aliases": [], "types": ["T044"], "canonical_name": "beta-carotene oxygenase activity", "definition": "Catalysis of the reaction: beta-carotene + 2 O2 = 2 beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial. [EC:1.13.11.-, GOC:pz]"}
{"concept_id": "C4690544", "aliases": [], "types": ["T044"], "canonical_name": "lutein oxygenase activity", "definition": "Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial. [EC:1.13.11.-, GOC:pz]"}
{"concept_id": "C4690545", "aliases": [], "types": ["T044"], "canonical_name": "violaxanthin oxygenase activity", "definition": "Catalysis of the reaction: violaxanthin + 2 O2 = 2 5,6-epoxy-3-hydroxy-9-apo-beta-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial. [GOC:pz, PMID:11316814]"}
{"concept_id": "C4690546", "aliases": [], "types": ["T044"], "canonical_name": "stearoyl-[acp] desaturase activity", "definition": "Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin. [EC:1.14.19.2, GOC:pz]"}
{"concept_id": "C4690547", "aliases": [], "types": ["T044"], "canonical_name": "caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "definition": "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690548", "aliases": [], "types": ["T044"], "canonical_name": "4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "definition": "Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690549", "aliases": [], "types": ["T044"], "canonical_name": "UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin = H+ + cyanidin 5-O-beta-D-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690550", "aliases": [], "types": ["T044"], "canonical_name": "cyanidin 5,3-O-glycosyltransferase activity", "definition": "Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690551", "aliases": [], "types": ["T044"], "canonical_name": "sulfuretin synthase activity", "definition": "Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 + 2 H+ = sulfuretin 6-glucoside + 2 H2O. [EC:1.21.3.6, GOC:pz]"}
{"concept_id": "C4690552", "aliases": [], "types": ["T044"], "canonical_name": "cinnamaldehyde:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide. [EC:1.2.3.9, GOC:pz]"}
{"concept_id": "C4690553", "aliases": [], "types": ["T044"], "canonical_name": "1-naphthaldehyde:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide. [EC:1.2.3.9, GOC:pz]"}
{"concept_id": "C4690556", "aliases": [], "types": ["T044"], "canonical_name": "glucosinolate glucohydrolase activity", "definition": "Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides. [EC:3.2.1.147, GOC:pz]"}
{"concept_id": "C4690557", "aliases": [], "types": ["T044"], "canonical_name": "caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity", "definition": "Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690558", "aliases": [], "types": ["T044"], "canonical_name": "anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity", "definition": "Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A. [GOC:pz, RHEA:35515]"}
{"concept_id": "C4690559", "aliases": [], "types": ["T044"], "canonical_name": "glutarate-semialdehyde dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+. [EC:1.2.1.-, GOC:pz]"}
{"concept_id": "C4690560", "aliases": [], "types": ["T044"], "canonical_name": "UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690561", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3'-O-methyltransferase activity", "definition": "Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine. [EC:2.1.1.42, GOC:pz]"}
{"concept_id": "C4690562", "aliases": [], "types": ["T044"], "canonical_name": "galactosylononitol-raffinose galactosyltransferase activity", "definition": "Catalysis of the reaction: raffinose + D-galactosylononitol = stachyose + 1D-4-O-methyl-myo-inositol. [EC:2.4.1.67, GOC:pz]"}
{"concept_id": "C4690563", "aliases": [], "types": ["T044"], "canonical_name": "stachyose synthase activity", "definition": "Catalysis of the reaction: 2 raffinose <=> stachyose + sucrose. [GOC:pz, PMID:12060258]"}
{"concept_id": "C4690564", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming)", "definition": "Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, RHEA:46412]"}
{"concept_id": "C4690565", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming)", "definition": "Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz, RHEA:46756]"}
{"concept_id": "C4690566", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming)", "definition": "Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4690567", "aliases": [], "types": ["T044"], "canonical_name": "1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming)", "definition": "Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:1-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [GOC:pz, RHEA:46404]"}
{"concept_id": "C4690568", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-18:1-phosphatidylcholine desaturase activity (SN2-18:2 forming)", "definition": "Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4690569", "aliases": [], "types": ["T044"], "canonical_name": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming)", "definition": "Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. [GOC:pz]"}
{"concept_id": "C4690570", "aliases": [], "types": ["T044"], "canonical_name": "gamma-terpinene synthase activity", "definition": "Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid. [GOC:pz, RHEA:32559]"}
{"concept_id": "C4690571", "aliases": [], "types": ["T044"], "canonical_name": "germacrene C synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid. [EC:4.2.3.60, GOC:pz]"}
{"concept_id": "C4690572", "aliases": [], "types": ["T044"], "canonical_name": "quarternary amine transporter activity"}
{"concept_id": "C4690573", "aliases": [], "types": ["T044"], "canonical_name": "alpha-ketoglutarate reductase activity (NADH-dependent)", "definition": "Catalysis of the reaction: NAD + 2-hydroxyglutarate = H+ + 2-oxoglutarate + NADH. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4690574", "aliases": [], "types": ["T044"], "canonical_name": "3-aminomethylindole N-methyltransferase activity", "definition": "Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4690575", "aliases": [], "types": ["T044"], "canonical_name": "N-methyl-3-aminomethylindole N-methyltransferase activity", "definition": "Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4690576", "aliases": [], "types": ["T044"], "canonical_name": "phenylpropanoyltransferase activity", "definition": "Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690577", "aliases": [], "types": ["T044"], "canonical_name": "3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity", "definition": "Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = H+ + paclitaxel + coenzyme A. [EC:2.3.1.-, GOC:pz]"}
{"concept_id": "C4690578", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity", "definition": "Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4690579", "aliases": [], "types": ["T044"], "canonical_name": "solanidine glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690580", "aliases": [], "types": ["T044"], "canonical_name": "beta-chaconine rhamnosyltransferase activity", "definition": "Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690581", "aliases": [], "types": ["T044"], "canonical_name": "beta-solanine rhamnosyltransferase activity", "definition": "Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690582", "aliases": [], "types": ["T044"], "canonical_name": "lachrymatory factor synthase activity", "definition": "Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide. [EC:5.3.-.-, GOC:pz]"}
{"concept_id": "C4690583", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxybenzoate geranyltransferase activity", "definition": "Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid. [GOC:pz, RHEA:27854]"}
{"concept_id": "C4690584", "aliases": [], "types": ["T044"], "canonical_name": "(Z,E)-alpha- farnesene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid. [GOC:pz, PMID:17140613]"}
{"concept_id": "C4690585", "aliases": [], "types": ["T044"], "canonical_name": "pterocarpan reductase activity", "definition": "Catalysis of the reaction: H+ + (-)-medicarpin + NADPH = (+)-vestitol + NADP. [EC:1.3.1.-, GOC:pz]"}
{"concept_id": "C4690586", "aliases": [], "types": ["T044"], "canonical_name": "GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity", "definition": "Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate. [GOC:pz, RHEA:36779]"}
{"concept_id": "C4690587", "aliases": [], "types": ["T044"], "canonical_name": "costunolide synthase activity", "definition": "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + O2 + NADPH + 2 H+ = costunolide + 2 H2O + NADP. [GOC:pz, RHEA:28230]"}
{"concept_id": "C4690588", "aliases": [], "types": ["T044"], "canonical_name": "gypsogenin-UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenin = gypsogenin-28-beta-D-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690589", "aliases": [], "types": ["T044"], "canonical_name": "gypsogenate-UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690590", "aliases": [], "types": ["T044"], "canonical_name": "16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP. [GOC:pz]"}
{"concept_id": "C4690591", "aliases": [], "types": ["T044"], "canonical_name": "orcinol O-methyltransferase activity", "definition": "Catalysis of the reaction: orcinol + S-adenosyl-L-methionine = H+ + 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine. [EC:2.1.1.6, GOC:pz]"}
{"concept_id": "C4690592", "aliases": [], "types": ["T044"], "canonical_name": "3-methoxy-5-hydroxytoluene O-methyltransferase activity", "definition": "Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4690593", "aliases": [], "types": ["T044"], "canonical_name": "phloroglucinol O-methyltransferase activity", "definition": "Catalysis of the reaction: phloroglucinol + S-adenosyl-L-methionine = H+ + 3,5-dihydroxyanisole + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4690594", "aliases": [], "types": ["T044"], "canonical_name": "3,5-dihydroxyanisole O-methyltransferase activity", "definition": "Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4690595", "aliases": [], "types": ["T044"], "canonical_name": "3,5-dimethoxyphenol O-methyltransferase activity", "definition": "Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine. [EC:2.1.1.-, GOC:pz]"}
{"concept_id": "C4690596", "aliases": [], "types": ["T044"], "canonical_name": "trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity", "definition": "Catalysis of the reaction: (2S,3S)-2,3-dihydro-3-hydroxyanthranilic acid = (1R,6S)-6-ammonio-5-oxocyclohex-2-ene-1-carboxylate. [GOC:pz, RHEA:28182]"}
{"concept_id": "C4690597", "aliases": [], "types": ["T044"], "canonical_name": "luteolin C-glucosyltransferase activity", "definition": "Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate + a glucosylated glucose acceptor = isoorientin + a non glucosylated glucose acceptor. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690598", "aliases": [], "types": ["T044"], "canonical_name": "1,2-rhamnosyltransferase activity", "definition": "Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor. [GOC:pz, PMID:15220389]"}
{"concept_id": "C4690599", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-valine synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4690600", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-acetyl-phenylalanine synthetase activity", "definition": "Catalysis of the reaction: indole-3-acetate + L-phenylalanine + ATP = H+ + indole-3-acetyl-phenylalanine + AMP + diphosphoric acid. [EC:6.3.-.-, GOC:pz]"}
{"concept_id": "C4690601", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690602", "aliases": [], "types": ["T044"], "canonical_name": "hypoglycin A gamma-glutamyl transpeptidase activity", "definition": "Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B. [EC:2.3.2.2, GOC:pz]"}
{"concept_id": "C4690603", "aliases": [], "types": ["T044"], "canonical_name": "S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity", "definition": "Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+. [GOC:pz, PMID:1444716, PMID:9045837, RHEA:33255]"}
{"concept_id": "C4690604", "aliases": [], "types": ["T044"], "canonical_name": "UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4690605", "aliases": [], "types": ["T044"], "canonical_name": "momilactone-A synthase activity", "definition": "Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H. [GOC:pz, RHEA:25367]"}
{"concept_id": "C4690606", "aliases": [], "types": ["T044"], "canonical_name": "4,4'-diapophytofluene desaturase activity", "definition": "Catalysis of the reaction: all-trans-4,4'-diapophytofluene + FAD + H+ = all-trans-4,4'-diapo-zeta-carotene + FADH2. [EC:1.3.8.-, GOC:pz]"}
{"concept_id": "C4690607", "aliases": [], "types": ["T044"], "canonical_name": "4,4'-diapo-zeta-carotene desaturase activity", "definition": "Catalysis of the reaction: all-trans-4,4'-diapo-zeta-carotene + FAD + H+ = 4,4'-diaponeurosporene + FADH2. [EC:1.3.8.-, GOC:pz]"}
{"concept_id": "C4690608", "aliases": [], "types": ["T044"], "canonical_name": "alcohol-forming fatty acyl-CoA reductase activity", "definition": "Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol. [EC:1.2.1.84, GOC:pz]"}
{"concept_id": "C4690609", "aliases": [], "types": ["T044"], "canonical_name": "arachidoyl-CoA:1-dodecanol O-acyltransferase activity", "definition": "Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A. [EC:2.3.1.75, GOC:pz]"}
{"concept_id": "C4690610", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming)", "definition": "Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4690611", "aliases": ["norsolorinic acid synthase"], "types": ["T044"], "canonical_name": "norsolorinate anthrone synthase activity", "definition": "Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]. [EC:2.3.1.221, GOC:pz]"}
{"concept_id": "C4690612", "aliases": [], "types": ["T044"], "canonical_name": "hydroxyversicolorone reductase activity", "definition": "Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH. [GOC:pz, RHEA:35691]"}
{"concept_id": "C4690613", "aliases": [], "types": ["T044"], "canonical_name": "nitrilotriacetate monooxygenase activity (FMN-dependent)", "definition": "Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN. [EC:1.14.14.10, GOC:pz]"}
{"concept_id": "C4690614", "aliases": [], "types": ["T044"], "canonical_name": "gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming)", "definition": "Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide. [EC:1.14.11.-, GOC:pz]"}
{"concept_id": "C4690615", "aliases": ["ferredoxin:thioredoxin reductase activity"], "types": ["T044"], "canonical_name": "ferredoxin-thioredoxin reductase activity", "definition": "Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin, involving a 4Fe-4S cluster and an adjacent active-site disulfide. [GOC:pz, PMID:14769790, RHEA:42336]"}
{"concept_id": "C4690616", "aliases": [], "types": ["T044"], "canonical_name": "beta-keto ester reductase activity", "definition": "Catalysis of the reaction: ethyl-(2R)-methyl-(3S)-hydroxybutanoate + NADP = ethyl-2-methylacetoacetate + NADPH + H+. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4690617", "aliases": [], "types": ["T044"], "canonical_name": "4-amino-4-deoxy-L-arabinose transferase activity", "definition": "Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate. [EC:2.4.2.43, GOC:pz]"}
{"concept_id": "C4690618", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-specific 2-thiouridylase activity", "definition": "Catalysis of the reaction: ATP + H+ + a tRNA uridine34 + a [TusE sulfur carrier protein]-S-sulfanylcysteine = AMP + diphosphoric acid + a tRNA 2-thiouridine34 + a [TusE sulfur carrier protein]-L-cysteine. [GOC:pz, PMID:12949933]"}
{"concept_id": "C4690620", "aliases": [], "types": ["T044"], "canonical_name": "FMN phosphatase activity", "definition": "Catalysis of the reaction: FMN + H2O = riboflavin + hydrogenphosphate. [EC:3.1.3.-, GOC:pz]"}
{"concept_id": "C4690621", "aliases": [], "types": ["T044"], "canonical_name": "murein hydrolase activity", "definition": "Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide. [EC:4.2.2.-, GOC:pz]"}
{"concept_id": "C4690622", "aliases": [], "types": ["T044"], "canonical_name": "ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity", "definition": "Catalysis of the reaction: H+ + methylglyoxal + NADH = hydroxyacetone + NAD. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4690623", "aliases": [], "types": ["T044"], "canonical_name": "L-Ala-D/L-Glu epimerase activity", "definition": "Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate. [EC:5.1.1.-, GOC:pz]"}
{"concept_id": "C4690624", "aliases": [], "types": ["T044"], "canonical_name": "beta-galactosidase activity (lactose isomerization)", "definition": "Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose. [EC:5.4.1.-, GOC:pz]"}
{"concept_id": "C4690625", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity", "definition": "Catalysis of the reaction: 3 H+ + methyl-1,4-benzoquinone + NADPH = methyl-1,4-benzoquinol + NADP. [EC:1.6.5.-, GOC:pz]"}
{"concept_id": "C4690626", "aliases": [], "types": ["T044"], "canonical_name": "L-glyceraldehyde 3-phosphate reductase activity", "definition": "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH. [EC:1.1.1.-, GOC:pz]"}
{"concept_id": "C4690627", "aliases": [], "types": ["T044"], "canonical_name": "protein methylthiotransferase activity", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor. [EC:2.8.4.4, GOC:pz]"}
{"concept_id": "C4690628", "aliases": [], "types": ["T044"], "canonical_name": "aldose sugar dehydrogenase activity", "definition": "Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor. [EC:1.1.5.-, GOC:pz]"}
{"concept_id": "C4690629", "aliases": [], "types": ["T044"], "canonical_name": "thiosulfate-thioredoxin sulfurtransferase activity", "definition": "Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin. [EC:2.8.1.-, GOC:pz]"}
{"concept_id": "C4690630", "aliases": [], "types": ["T044"], "canonical_name": "ribosomal protein S6 glutamate-glutamate ligase activity", "definition": "Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate. [EC:6.3.2.-, GOC:pz]"}
{"concept_id": "C4690631", "aliases": [], "types": ["T044"], "canonical_name": "methione N-acyltransferase activity", "definition": "Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+. [EC:2.3.1.1, GOC:pz]"}
{"concept_id": "C4690632", "aliases": [], "types": ["T044"], "canonical_name": "methyl beta-D-glucoside 6-phosphate glucohydrolase activity", "definition": "Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol. [EC:3.2.1.86, GOC:pz]"}
{"concept_id": "C4690633", "aliases": [], "types": ["T044"], "canonical_name": "inositol phosphorylceramide mannosyltransferase activity", "definition": "Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+. [GOC:pz, RHEA:64596]"}
{"concept_id": "C4690634", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity", "definition": "Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H. [EC:1.1.1.170, GOC:pz]"}
{"concept_id": "C4690635", "aliases": [], "types": ["T044"], "canonical_name": "4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity", "definition": "Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H. [GOC:pz, RHEA:33447]"}
{"concept_id": "C4690636", "aliases": [], "types": ["T044"], "canonical_name": "leukotriene C4 gamma-glutamyl transferase activity", "definition": "Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. [GOC:pz, PMID:1676842, PMID:9139674]"}
{"concept_id": "C4690637", "aliases": [], "types": ["T044"], "canonical_name": "straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity", "definition": "Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde. [EC:4.1.-.-, GOC:pz]"}
{"concept_id": "C4690638", "aliases": [], "types": ["T044"], "canonical_name": "glucose-6-phosphate 3-dehydrogenase activity", "definition": "Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate. [GOC:pz, RHEA:37547]"}
{"concept_id": "C4690639", "aliases": [], "types": ["T039"], "canonical_name": "cellular response to environmental stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus. [GOC:dos]"}
{"concept_id": "C4690640", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,4-bisphosphate phosphatase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. [GOC:hjd]"}
{"concept_id": "C4690641", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-3,5-bisphosphate phosphatase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. [GOC:hjd]"}
{"concept_id": "C4690642", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylinositol-4,5-bisphosphate phosphatase activity", "definition": "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. [GOC:hjd]"}
{"concept_id": "C4690643", "aliases": ["regulation of vesicle to membrane docking"], "types": ["T043"], "canonical_name": "regulation of vesicle docking", "definition": "Any process that modulates the frequency, rate or extent of vesicle docking. [PMID:22810233]"}
{"concept_id": "C4690644", "aliases": ["negative regulation of vesicle to membrane docking"], "types": ["T043"], "canonical_name": "negative regulation of vesicle docking", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle docking. [PMID:22810233]"}
{"concept_id": "C4690645", "aliases": ["positive regulation of vesicle to membrane docking"], "types": ["T043"], "canonical_name": "positive regulation of vesicle docking", "definition": "Any process that activates or increases the frequency, rate or extent of vesicle docking. [PMID:22810233]"}
{"concept_id": "C4690646", "aliases": [], "types": ["T040"], "canonical_name": "regulation of pupariation", "definition": "Any process that modulates the onset of pupariation. [PMID:26510564]"}
{"concept_id": "C4690647", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of pupariation", "definition": "Any process that stops, prevents or reduces the rate of onset of pupariation. [PMID:26510564]"}
{"concept_id": "C4690648", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of pupariation", "definition": "Any process that activates or increases the frequency, rate or extent of onset of pupariation. [GOC:hjd]"}
{"concept_id": "C4690649", "aliases": [], "types": ["T044"], "canonical_name": "Gly-tRNA(Ala) hydrolase activity", "definition": "Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala). [PMID:28362257]"}
{"concept_id": "C4690650", "aliases": [], "types": ["T043"], "canonical_name": "neuron projection organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. [GOC:aruk, GOC:bc, PMID:11585923]"}
{"concept_id": "C4690651", "aliases": ["neuron projection disassembly"], "types": ["T043"], "canonical_name": "neuron projection retraction", "definition": "The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:aruk, GOC:bc, PMID:11585923.]"}
{"concept_id": "C4690652", "aliases": [], "types": ["T044"], "canonical_name": "Mitochondrial tRNA pseudouridine(27/28) synthase"}
{"concept_id": "C4690653", "aliases": [], "types": ["T045"], "canonical_name": "tRNA pseudouridine(13) synthase"}
{"concept_id": "C4690654", "aliases": [], "types": ["T044"], "canonical_name": "tRNA pseudouridine(31) synthase"}
{"concept_id": "C4690655", "aliases": [], "types": ["T044"], "canonical_name": "tRNA pseudouridine(32) synthase"}
{"concept_id": "C4690656", "aliases": [], "types": ["T044"], "canonical_name": "tRNA pseudouridine(38/39) synthase"}
{"concept_id": "C4690657", "aliases": [], "types": ["T044"], "canonical_name": "tRNA pseudouridine(55) synthase"}
{"concept_id": "C4690658", "aliases": [], "types": ["T044"], "canonical_name": "tRNA pseudouridine(65) synthase"}
{"concept_id": "C4690659", "aliases": [], "types": ["T045"], "canonical_name": "tRNA pseudouridylate synthase I activity"}
{"concept_id": "C4690660", "aliases": [], "types": ["T043"], "canonical_name": "neuron projection fasciculation", "definition": "The collection of neuronal projections into a bundle of rods, known as a fascicle. [GOC:aruk, GOC:bc., PMID:12761826]"}
{"concept_id": "C4690661", "aliases": [], "types": ["T044"], "canonical_name": "snRNA pseudouridine synthase activity", "definition": "Catalysis of the reaction: an snRNA uridine = an snRNA pseudouridine. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [PMID:28432181]"}
{"concept_id": "C4690662", "aliases": ["dendritic spine synapse"], "types": ["T026"], "canonical_name": "spine synapse", "definition": "A type of synapse occurring between an axon and a dendritic spine. [PMID:15028757]"}
{"concept_id": "C4690663", "aliases": [], "types": ["T044"], "canonical_name": "protein maturation by [2Fe-2S] cluster transfer", "definition": "The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. [PMID:23615440]"}
{"concept_id": "C4690664", "aliases": [], "types": ["T044"], "canonical_name": "protein maturation by [4Fe-4S] cluster transfer", "definition": "The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. [PMID:23615440]"}
{"concept_id": "C4690665", "aliases": [], "types": ["T043"], "canonical_name": "assembly of apicomedial cortex actomyosin", "definition": "A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin. [PMID:28263180]"}
{"concept_id": "C4690666", "aliases": ["medioapical cortex"], "types": ["T026"], "canonical_name": "apicomedial cortex", "definition": "The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell. [PMID:23831726, PMID:28263180]"}
{"concept_id": "C4690668", "aliases": [], "types": ["T044"], "canonical_name": "regulation of GABA-A receptor activity", "definition": "Any process that modulates the frequency, rate or extent of GABA-A receptor activity. [PMID:24044036]"}
{"concept_id": "C4690669", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of GABA-A receptor activity", "definition": "Any process that activates or increases the frequency, rate or extent of GABA-A receptor activity. [PMID:24044036]"}
{"concept_id": "C4690670", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of GABA-A receptor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of GABA-A receptor activity. [PMID:24044036]"}
{"concept_id": "C4690671", "aliases": [], "types": ["T044"], "canonical_name": "guanine deglycation", "definition": "The removal of a sugar or dicarbonyl from a glycated guanine. [PMID:28596309]"}
{"concept_id": "C4690672", "aliases": [], "types": ["T044"], "canonical_name": "guanine deglycation, methylglyoxal removal", "definition": "The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine. [PMID:28596309]"}
{"concept_id": "C4690673", "aliases": [], "types": ["T043"], "canonical_name": "guanine deglycation, glyoxal removal", "definition": "The removal of glyoxal from a glycated guanine, to form glycolate and a deglycated guanine. [PMID:28596309]"}
{"concept_id": "C4690674", "aliases": [], "types": ["T044"], "canonical_name": "polyamine deacetylation", "definition": "The modification of acetylpolyamine by the removal of acetyl groups. [PMID:28516954]"}
{"concept_id": "C4690675", "aliases": ["N8-acetylspermidine deacetylation"], "types": ["T044"], "canonical_name": "spermidine deacetylation", "definition": "The modification of acetylspermadine by the removal of acetyl groups. [PMID:28516954]"}
{"concept_id": "C4690676", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to osmotic stress", "definition": "Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress. [PMID:10398679]"}
{"concept_id": "C4690677", "aliases": [], "types": ["T044"], "canonical_name": "tRNA 2'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide. [PMID:17242307]"}
{"concept_id": "C4690678", "aliases": ["tRNA U34 thiol-transferase activity", "tRNA U34 2-thiouridylase"], "types": ["T044"], "canonical_name": "tRNA U34 sulfurtransferase activity", "definition": "Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+. [PMID:12549933, PMID:16387657]"}
{"concept_id": "C4690679", "aliases": [], "types": ["T044"], "canonical_name": "tRNA-specific 2-thiouridylase"}
{"concept_id": "C4690680", "aliases": ["mannosyl-oligosaccharide 1,2-alpha-mannosidase complex location"], "types": ["T026"], "canonical_name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase complex", "definition": "A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. [GOC:bhm, PMID:21700223]"}
{"concept_id": "C4690681", "aliases": [], "types": ["T044"], "canonical_name": "regulation of calcineurin-mediated signaling", "definition": "Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling. [PMID:25081204]"}
{"concept_id": "C4690682", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of calcineurin-mediated signaling", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signalling. [PMID:25081204]"}
{"concept_id": "C4690683", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of calcineurin-mediated signaling", "definition": "Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling. [PMID:25081204]"}
{"concept_id": "C4690684", "aliases": [], "types": ["T045"], "canonical_name": "tRNA (cytidine 56-2'-O)-methyltransferase", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA. [EC:2.1.1.206]"}
{"concept_id": "C4690685", "aliases": [], "types": ["T044"], "canonical_name": "regulation of exit from meiosis", "definition": "Any process that modulates the frequency, rate or extent of exit from mitosis. [GOC:al, PMID:11493649]"}
{"concept_id": "C4690686", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of exit from meiosis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of exit from meiosis. [GOC:al, PMID:11493649]"}
{"concept_id": "C4690687", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of exit from meiosis", "definition": "Any process that activates or increases the frequency, rate or extent of exit from meiosis. [GOC:al, PMID:11493649]"}
{"concept_id": "C4690688", "aliases": ["G-protein coupled folate receptor activity", "G-protein coupled folic acid receptor activity"], "types": ["T044"], "canonical_name": "G protein-coupled folate receptor activity", "definition": "Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity. [PMID:26906738]"}
{"concept_id": "C4690689", "aliases": [], "types": ["T044"], "canonical_name": "regulation of cobalamin metabolic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. [PMID:29056341]"}
{"concept_id": "C4690690", "aliases": ["SUMO-protein ligase complex location", "Sumoylation complex", "SUMO transferase complex location", "Sumoylation complex location", "SUMO-protein ligase complex", "SUMO transferase complex", "SUMO ligase complex location"], "types": ["T026"], "canonical_name": "SUMO ligase complex", "definition": "A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex. [PMID:16847351]"}
{"concept_id": "C4690691", "aliases": ["synapsis initiation complex location"], "types": ["T026"], "canonical_name": "synapsis initiation complex", "definition": "A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. [PMID:16847351]"}
{"concept_id": "C4690692", "aliases": ["regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway"], "types": ["T043"], "canonical_name": "regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. [GOC:hjd, PMID:19246489]"}
{"concept_id": "C4690693", "aliases": ["positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. [GOC:hjd, PMID:19246489]"}
{"concept_id": "C4690694", "aliases": ["negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. [GOC:hjd, PMID:19246489]"}
{"concept_id": "C4690695", "aliases": [], "types": ["T044"], "canonical_name": "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity", "definition": "Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. [GOC:ha, PMID:9597543]"}
{"concept_id": "C4690696", "aliases": [], "types": ["T045"], "canonical_name": "aminoacyl-tRNA metabolism involved in translational fidelity", "definition": "Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation. [GOC:hjd]"}
{"concept_id": "C4690697", "aliases": [], "types": ["T045"], "canonical_name": "aminoacyl-tRNA correction"}
{"concept_id": "C4690698", "aliases": [], "types": ["T045"], "canonical_name": "aminoacyl-tRNA editin"}
{"concept_id": "C4690699", "aliases": [], "types": ["T045"], "canonical_name": "aminoacyl-tRNA proofreading"}
{"concept_id": "C4690700", "aliases": [], "types": ["T044"], "canonical_name": "peptide N-succinyltransferase activity", "definition": "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide. [PMID:29211711]"}
{"concept_id": "C4690701", "aliases": [], "types": ["T044"], "canonical_name": "peptide-lysine-N-succinyltransferase activity", "definition": "Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide. [PMID:29211711]"}
{"concept_id": "C4690702", "aliases": [], "types": ["T044"], "canonical_name": "histone succinylation", "definition": "The modification of a histone by the addition of an succinyl group. [PMID:29211711]"}
{"concept_id": "C4690703", "aliases": [], "types": ["T044"], "canonical_name": "histone succinyltransferase activity", "definition": "Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone. [PMID:29211711]"}
{"concept_id": "C4690704", "aliases": [], "types": ["T044"], "canonical_name": "GATOR1 complex binding", "definition": "Binding to a GATOR1 complex. [PMID:28199306]"}
{"concept_id": "C4690705", "aliases": [], "types": ["T043"], "canonical_name": "maltose import across plasma membrane", "definition": "The directed movement of maltose from outside of a cell, across the plasma membrane and into the cytosol. [PMID:11136464]"}
{"concept_id": "C4690706", "aliases": [], "types": ["T043"], "canonical_name": "sucrose import across plasma membrane", "definition": "The directed movement of sucrose from outside of a cell, across the plasma membrane and into the cytosol. [PMID:11136464]"}
{"concept_id": "C4690707", "aliases": ["nuclear membrane protein complex location"], "types": ["T026"], "canonical_name": "nuclear membrane protein complex", "definition": "Any protein complex that is part of the nuclear membrane. [GOC:lnp, PMID:28356353]"}
{"concept_id": "C4690708", "aliases": ["nuclear membrane mitotic spindle pole body tethering complex location", "nuclear membrane mitotic spindle pole body tethering complex", "mitotic nuclear membrane microtubule tethering complex location"], "types": ["T026"], "canonical_name": "mitotic nuclear membrane microtubule tethering complex", "definition": "A protein complex capable of interacting with the spindle pole body and the nuclear envelope, in order to embed the spindle pole body in the nuclear envelope at fusion sites of the inner and outer nuclear membrane. [GOC:lnp, PMID:28356353]"}
{"concept_id": "C4690709", "aliases": ["Mps2-Bbp1-Spc29 complex location"], "types": ["T026"], "canonical_name": "Mps2-Bbp1-Spc29 complex"}
{"concept_id": "C4690710", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell adhesion involved in sprouting angiogenesis", "definition": "Any process that modulates the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325]"}
{"concept_id": "C4690711", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell adhesion involved in sprouting angiogenesis", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325]"}
{"concept_id": "C4690712", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell adhesion involved in sprouting angiogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325]"}
{"concept_id": "C4690713", "aliases": [], "types": ["T043"], "canonical_name": "glial cell projection elongation", "definition": "The process of creating an elongation or projection from a glial cell. [GOC:ha, PMID:27131624]"}
{"concept_id": "C4690714", "aliases": [], "types": ["T043"], "canonical_name": "glial cell projection elongation involved in axon ensheathment", "definition": "The extension of a glial cell process or projection to wrap around an axon. [GOC:ha, PMID:27131624]"}
{"concept_id": "C4690715", "aliases": ["EDS1 disease-resistance complex location"], "types": ["T026"], "canonical_name": "EDS1 disease-resistance complex", "definition": "A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes. [GOC:bhm, PMID:11574472, PMID:16040633]"}
{"concept_id": "C4690716", "aliases": ["EDS1-PAD4 complex location"], "types": ["T026"], "canonical_name": "EDS1-PAD4 complex"}
{"concept_id": "C4690717", "aliases": ["EDS1-PAD4-SAG101 complex location"], "types": ["T026"], "canonical_name": "EDS1-PAD4-SAG101 complex"}
{"concept_id": "C4690718", "aliases": ["EDS1-SAG101 complex location"], "types": ["T026"], "canonical_name": "EDS1-SAG101 complex"}
{"concept_id": "C4690719", "aliases": ["nuclear membrane microtubule tethering complex location"], "types": ["T026"], "canonical_name": "nuclear membrane microtubule tethering complex", "definition": "A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links thereby links the nuclear lumen to cytoplasmic microtubules. [GOC:vw, PMID:19225124]"}
{"concept_id": "C4690720", "aliases": ["m7G(5')pppN diphosphatase enzyme", "m7G(5')pppN diphosphatase complex location", "DCS1 decapping scavenger complex location", "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase enzyme", "M(7)G(5')pppN pyrophosphatase enzyme", "m7G(5')pppN pyrophosphatase enzyme", "DCS1 decapping scavenger complex"], "types": ["T026"], "canonical_name": "m7G(5')pppN diphosphatase complex", "definition": "A homodimeric protein complex that catalyzes the reaction: 7-methylguanosine-5'-triphospho-5'-pholynucleotide + H20 = 7-methylguanosine-5'-phosphate + polynucleotide. [GOC:lnp, PMID:22985415, PMID:26258763]"}
{"concept_id": "C4690721", "aliases": [], "types": ["T043"], "canonical_name": "response to ceramide", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus. [PMID:18006463]"}
{"concept_id": "C4690722", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to ceramide", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus. [PMID:18006463]"}
{"concept_id": "C4690723", "aliases": ["NAGS/NAGK complex location"], "types": ["T026"], "canonical_name": "NAGS/NAGK complex", "definition": "A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate. [GOC:lnp, PMID:11553611]"}
{"concept_id": "C4690724", "aliases": [], "types": ["T044"], "canonical_name": "2-keto-3-deoxy-L-rhamnonate aldolase activity", "definition": "Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde. [EC:4.1.2.53, GOC:imk, PMID:18754683]"}
{"concept_id": "C4690725", "aliases": [], "types": ["T044"], "canonical_name": "beta-pinacene synthase activity", "definition": "Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene. [GOC:rjd, PMID:28696553]"}
{"concept_id": "C4690726", "aliases": [], "types": ["T043"], "canonical_name": "ER-dependent peroxisome localization", "definition": "A process in which a protein is transported to, or maintained at, a location in a peroxisome via the endoplasmic reticulum. [GOC:pga, PMID:19479899, PMID:26408931]"}
{"concept_id": "C4690727", "aliases": ["GRASP65-GM130 complex location", "COPII vesicles tethering complex location", "GRASP65-GM130 complex"], "types": ["T026"], "canonical_name": "COPII vesicles tethering complex", "definition": "A protein complex that resides in the cis-golgi membrane and plays a role in the tethering of COPII vesicles, through an interaction with vesicle tethering proteins (p115 in H. Sapiens and Uso1 S. cerevisiae), granting the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. It is composed by GRASP65 and GM130 protein in H. sapiens and by Bug1 and Grh1 proteins in S. cerevisiae. [GOC:lnp, PMID:21482742, PMID:9628863]"}
{"concept_id": "C4690728", "aliases": ["Bug1-Grh1 complex location"], "types": ["T026"], "canonical_name": "Bug1-Grh1 complex"}
{"concept_id": "C4690729", "aliases": [], "types": ["T043"], "canonical_name": "regulation of glutamate receptor clustering", "definition": "Any process that modulates the frequency, rate or extent of glutamate receptor clustering. [GOC:ha, PMID:28455372]"}
{"concept_id": "C4690730", "aliases": ["L-alanyl-tRNA(Thr) deacylase"], "types": ["T045"], "canonical_name": "Ala-tRNA(Thr) hydrolase activity", "definition": "Catalysis of the hydrolysis of misacylated ala-tRNA(thr). [PMID:29410408]"}
{"concept_id": "C4690731", "aliases": [], "types": ["T044"], "canonical_name": "regulation of (R)-mevalonic acid biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of (R)-mevalonic acid biosynthetic process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663]"}
{"concept_id": "C4690732", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of (R)-mevalonic acid biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of (R)-mevalonic acid biosynthetic process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663]"}
{"concept_id": "C4690733", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of (R)-mevalonic acid biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of (R)-mevalonic acid biosynthetic process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663]"}
{"concept_id": "C4690734", "aliases": ["vomitoxin formation", "vomitoxin synthesis", "vomitoxin anabolism", "vomitoxin biosynthesis", "DON biosynthetic process", "deoxynivalenol biosynthetic process"], "types": ["T044"], "canonical_name": "vomitoxin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, also known as deoxynivalenol, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats. [http://www.inchem.org/documents/jecfa/jecmono/v47je05.htm, https://doi.org/10.1007/BF03356188, PMID:19333439, PMID:25680507, PMID:25758923, PMID:8637056]"}
{"concept_id": "C4690735", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mitotic cohesin ssDNA (lagging strand) loading", "definition": "Any process that modulates the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading. [PMID:29358048]"}
{"concept_id": "C4690736", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic cohesin ssDNA (lagging strand) loading", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading. [PMID:29358048]"}
{"concept_id": "C4690737", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic cohesin ssDNA (lagging strand) loading", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading. [PMID:29358048]"}
{"concept_id": "C4690738", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic cohesin dsDNA (leading strand) loading", "definition": "Any process that modulates the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading. [PMID:29358048]"}
{"concept_id": "C4690739", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of mitotic cohesin dsDNA (leading strand) loading", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading. [PMID:29358048]"}
{"concept_id": "C4690740", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic cohesin dsDNA (leading strand) loading", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading. [PMID:29358048]"}
{"concept_id": "C4690741", "aliases": ["volutin granule organization", "acidocalcisome organisation", "acidocalcisome biogenesis", "metachromatic granule organization", "acidocalcisome organization and biogenesis"], "types": ["T043"], "canonical_name": "acidocalcisome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an acidocalcisome. An acidocalcisome is an electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations. [GO:0020022, PMID:25964650, PMID:26523947]"}
{"concept_id": "C4690742", "aliases": [], "types": ["T043"], "canonical_name": "polyphosphate vacuole organization"}
{"concept_id": "C4690743", "aliases": [], "types": ["T044"], "canonical_name": "regulation of sterol biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of a sterol biosynthetic process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310]"}
{"concept_id": "C4690744", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of sterol biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a sterol biosynthetic process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310]"}
{"concept_id": "C4690745", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of sterol biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of a sterol biosynthetic process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310]"}
{"concept_id": "C4690746", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cobalamin metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process. [PMID:29056341]"}
{"concept_id": "C4690747", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cobalamin metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process. [PMID:29056341]"}
{"concept_id": "C4690748", "aliases": [], "types": ["T026"], "canonical_name": "reservosome", "definition": "A large membrane-bound endocytic organelle present only in members of the Schizotrypanum subgenus of the Trypanosoma genus and is defined as the site of storage of endocytosed macromolecules and lysosomal enzymes. It is found at the posterior end of epimastigote forms of Trypanosoma cruzi, but absent in amastigotes and trypomastigotes. [GOC:ach, PMID:12204365, PMID:15521631, PMID:1845219, PMID:19288526, PMID:21818313, PMID:22425988]"}
{"concept_id": "C4690749", "aliases": [], "types": ["T026"], "canonical_name": "reservosome lumen", "definition": "The volume enclosed by the membranes of a reservosome. [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988]"}
{"concept_id": "C4690750", "aliases": [], "types": ["T026"], "canonical_name": "reservosome matrix", "definition": "A matrix composed of planar membranes, vesicles and lipid inclusions within the reservosome. [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988]"}
{"concept_id": "C4690751", "aliases": [], "types": ["T026"], "canonical_name": "reservosome membrane", "definition": "The lipid bilayer surrounding a reservosome. [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988]"}
{"concept_id": "C4690752", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of store-operated calcium entry", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium entry. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23447642]"}
{"concept_id": "C4690753", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of store-operated calcium entry", "definition": "Any process that activates or increases the frequency, rate or extent of store-operated calcium entry. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23447642]"}
{"concept_id": "C4690754", "aliases": ["protein localization to cytoplasmic mRNA processing body", "protein localization to P body", "protein localisation to P-body"], "types": ["T043"], "canonical_name": "protein localization to P-body", "definition": "Any process in which a protein is transported to, or maintained at, a P-body. [GOC:mah, PMID:28031482]"}
{"concept_id": "C4690755", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of aggregation involved in sorocarp development", "definition": "Any process that increases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. [GOC:rjd, PMID:28257811]"}
{"concept_id": "C4690756", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of aggregation involved in sorocarp development", "definition": "Any process that decreases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. [GOC:rjd, PMID:28257811]"}
{"concept_id": "C4690757", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of elastin catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4690758", "aliases": ["B-WICH complex location"], "types": ["T026"], "canonical_name": "B-WICH complex", "definition": "A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself. [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184]"}
{"concept_id": "C4690759", "aliases": [], "types": ["T045"], "canonical_name": "cap-independent translational initiation of linear mRNA", "definition": "The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation. [GOC:kmv]"}
{"concept_id": "C4690760", "aliases": ["cap-independent translational initiation of circRNA"], "types": ["T045"], "canonical_name": "cap-independent translational initiation of circular RNA", "definition": "The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate circRNA translation. [GOC:sp, PMID:28281539, PMID:28344080, PMID:28344082]"}
{"concept_id": "C4690761", "aliases": ["IRES-dependent translational initiation of circRNA"], "types": ["T045"], "canonical_name": "IRES-dependent translational initiation of circular RNA", "definition": "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate circular mRNA translation. [GOC:sp, PMID:28281539, PMID:28344080, PMID:28344082]"}
{"concept_id": "C4690762", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actomyosin structure organization", "definition": "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. [GOC:lf, PMID:22790195]"}
{"concept_id": "C4690763", "aliases": [], "types": ["T043"], "canonical_name": "cardiac muscle myoblast proliferation", "definition": "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]"}
{"concept_id": "C4690764", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cardiac muscle myoblast proliferation", "definition": "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]"}
{"concept_id": "C4690765", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cardiac muscle myoblast proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]"}
{"concept_id": "C4690766", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cardiac muscle myoblast proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]"}
{"concept_id": "C4690767", "aliases": [], "types": ["T045"], "canonical_name": "DNA strand resection involved in replication fork processing", "definition": "The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing. [GOC:mah, PMID:28475874]"}
{"concept_id": "C4690768", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA strand resection involved in replication fork processing", "definition": "Any process that modulates the frequency, rate or extent of DNA strand resection involved in replication fork processing. [GOC:mah, PMID:28475874]"}
{"concept_id": "C4690769", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of DNA strand resection involved in replication fork processing", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing. [GOC:mah, PMID:28475874]"}
{"concept_id": "C4690770", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic spindle organization", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic spindle organization. [GOC:bhm, PMID:17576815]"}
{"concept_id": "C4690771", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of meiosis I", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells. [GOC:vw]"}
{"concept_id": "C4690772", "aliases": [], "types": ["T044"], "canonical_name": "regulation of G2/MI transition of meiotic cell cycle", "definition": "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. [GOC:vw]"}
{"concept_id": "C4690773", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of G2/MI transition of meiotic cell cycle", "definition": "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. [GOC:vw, PMID:25492408]"}
{"concept_id": "C4690774", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of G2/MI transition of meiotic cell cycle", "definition": "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. [GOC:vw, PMID:25492408]"}
{"concept_id": "C4690775", "aliases": ["regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway"], "types": ["T043"], "canonical_name": "regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway, the series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). [GOC:al, PMID:24297439]"}
{"concept_id": "C4690776", "aliases": ["negative regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway"], "types": ["T044"], "canonical_name": "negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway. [GOC:al, PMID:24297439]"}
{"concept_id": "C4690777", "aliases": [], "types": ["T045"], "canonical_name": "rDNA spacer replication fork barrier binding, bending", "definition": "The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. [GOC:al, GOC:vw, PMID:27035982]"}
{"concept_id": "C4690778", "aliases": [], "types": ["T044"], "canonical_name": "C2 domain binding", "definition": "Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes. [GOC:sl, PMID:24882364]"}
{"concept_id": "C4690779", "aliases": [], "types": ["T038"], "canonical_name": "regulation of nematode male tail tip morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of nematode male tail tip morphogenesis, the process in which the anatomical structure of the adult male tail tip is generated and organized. [GOC:rz, PMID:28068334]"}
{"concept_id": "C4690780", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of nematode male tail tip morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of nematode male tail tip morphogenesis. [GOC:rz, PMID:28068334]"}
{"concept_id": "C4690781", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of nematode male tail tip morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis. [GOC:rz, PMID:28068334]"}
{"concept_id": "C4690782", "aliases": [], "types": ["T040"], "canonical_name": "pharynx morphogenesis", "definition": "The process in which the anatomical structures of the pharynx are generated and organized. [GOC:rz, PMID:20805556]"}
{"concept_id": "C4690783", "aliases": [], "types": ["T038"], "canonical_name": "regulation of pharynx morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of pharynx morphogenesis, the process in which the anatomical structure of the pharynx is generated and organized. [GOC:rz, PMID:20805556]"}
{"concept_id": "C4690784", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of pharynx morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of pharynx morphogenesis. [GOC:rz, PMID:20805556]"}
{"concept_id": "C4690785", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of pharynx morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of pharynx morphogenesis. [GOC:rz, PMID:20805556]"}
{"concept_id": "C4690786", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell cycle switching, mitotic to meiotic cell cycle", "definition": "Any process that modulates the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division. [GOC:al, PMID:17674143]"}
{"concept_id": "C4690787", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell cycle switching, mitotic to meiotic cell cycle", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division. [GOC:al, PMID:17674143]"}
{"concept_id": "C4690788", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle", "definition": "A signal transduction process that contributes to cell cycle switching, mitotic to meiotic cell cycle. [GOC:al, PMID:17674143]"}
{"concept_id": "C4690789", "aliases": [], "types": ["T044"], "canonical_name": "deaminated glutathione amidase activity", "definition": "Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine. [GOC:ka, PMID:28373563, RHEA:54532]"}
{"concept_id": "C4690790", "aliases": [], "types": ["T043"], "canonical_name": "metabolite repair", "definition": "A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites. [GOC:ka, PMID:23334546, PMID:28373563]"}
{"concept_id": "C4690791", "aliases": [], "types": ["T043"], "canonical_name": "toxic metabolite repair", "definition": "A cellular process that, through single- or multi-step enzymatic reactions, repairs toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites. [GOC:ka, GOC:vw, PMID:23334546]"}
{"concept_id": "C4690792", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament organization", "definition": "Any process that modulates the frequency, rate or extent of actin filament organization. [GOC:kmv]"}
{"concept_id": "C4690793", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament annealing", "definition": "Any process that modulates the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments. [GOC:mah, PMID:10585915, PMID:11575927, PMID:15743909, PMID:19244341]"}
{"concept_id": "C4690794", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of actin filament annealing", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments. [GOC:mah, PMID:15743909]"}
{"concept_id": "C4690795", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of actin filament annealing", "definition": "Any process that activates or increases the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments. [GOC:mah, PMID:10585915, PMID:11575927, PMID:19244341]"}
{"concept_id": "C4690796", "aliases": [], "types": ["T043"], "canonical_name": "regulation of blood vessel endothelial cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]"}
{"concept_id": "C4690797", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of blood vessel endothelial cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]"}
{"concept_id": "C4690798", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of blood vessel endothelial cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]"}
{"concept_id": "C4690799", "aliases": [], "types": ["T043"], "canonical_name": "regulation of angiotensin-activated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway. [GOC:lf, PMID:28784619]"}
{"concept_id": "C4690800", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of angiotensin-activated signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway. [GOC:lf, PMID:28784619]"}
{"concept_id": "C4690801", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of angiotensin-activated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway. [GOC:lf, PMID:28784619]"}
{"concept_id": "C4690802", "aliases": ["lncRNA catabolism", "lncRNA degradation", "lncRNA breakdown"], "types": ["T045"], "canonical_name": "lncRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lncRNAs, non-coding RNAs over 200 nucleotides in length. [GOC:al, PMID:24493644]"}
{"concept_id": "C4690803", "aliases": ["regulation of mitotic telomere clustering during interphase"], "types": ["T043"], "canonical_name": "regulation of interphase mitotic telomere clustering", "definition": "Any process that modulates the frequency, rate or extent of mitotic telomere clustering during interphase. [GOC:vw, PMID:25778919]"}
{"concept_id": "C4690804", "aliases": ["telomere dispersion during interphase", "negative regulation of mitotic telomere clustering during interphase"], "types": ["T039"], "canonical_name": "negative regulation of interphase mitotic telomere clustering", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of mitotic telomere clustering during interphase. [GOC:vw, PMID:25778919]"}
{"concept_id": "C4690805", "aliases": ["ammonium transmembrane transporter complex location"], "types": ["T026"], "canonical_name": "ammonium transmembrane transporter complex", "definition": "High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other. [GOC:bhm, PMID:17026539, PMID:23463773]"}
{"concept_id": "C4690806", "aliases": ["AMT1 complex location"], "types": ["T026"], "canonical_name": "AMT1 complex"}
{"concept_id": "C4690807", "aliases": [], "types": ["T044"], "canonical_name": "glucosylglycerate phosphorylase activity", "definition": "Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate. [GOC:imk, PMID:28754708]"}
{"concept_id": "C4690808", "aliases": [], "types": ["T043"], "canonical_name": "syncytial embryo cellularization", "definition": "The separation of a syncytial embryo into individual cells. [GOC:ha, PMID:27226317]"}
{"concept_id": "C4690809", "aliases": [], "types": ["T026"], "canonical_name": "cellularization cleavage furrow", "definition": "A plasma membrane invagination at the site of separation of a multi-nucleate cell or syncytium into individual cells. [GOC:ha, PMID:27226317]"}
{"concept_id": "C4690810", "aliases": [], "types": ["T026"], "canonical_name": "cellularization cleavage furrow invagination front", "definition": "The base of the cellularization invagination or cleavage furrow most distal to the original multi-nucleate cell or syncytium plasma membrane. [GOC:ha, PMID:27226317]"}
{"concept_id": "C4690811", "aliases": [], "types": ["T043"], "canonical_name": "apical constriction involved in ventral furrow formation", "definition": "The actin-mediated process that results in contraction of the apical end of a polarized columnar epithelial cell, contributing to formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation. [GOC:ha, PMID:28495958]"}
{"concept_id": "C4690812", "aliases": [], "types": ["T039"], "canonical_name": "regulation of apical constriction involved in ventral furrow formation", "definition": "Any process that modulates the frequency, rate or extent of apical constriction involved in ventral furrow formation. [GOC:ha, PMID:28495958]"}
{"concept_id": "C4690813", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apical constriction involved in ventral furrow formation", "definition": "Any process that activates or increases the frequency, rate or extent of apical constriction involved in ventral furrow formation. [GOC:ha, PMID:28495958]"}
{"concept_id": "C4690814", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ferroptosis", "definition": "Any process that modulates the frequency, rate or extent of ferroptosis. [GOC:sp, PMID:24439385, PMID:25402683, PMID:29290465]"}
{"concept_id": "C4690815", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of ferroptosis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ferroptosis. [GOC:sp, PMID:24439385, PMID:25402683, PMID:29290465]"}
{"concept_id": "C4690816", "aliases": [], "types": ["T043"], "canonical_name": "vesicle-mediated intercellular transport", "definition": "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. [GOC:sp, PMID:29328915, PMID:29328916]"}
{"concept_id": "C4690817", "aliases": ["TELO2-TTI1-TTI2", "TTT complex location", "Tel2-Tti1-Tti2", "Triple T complex location", "Triple T complex"], "types": ["T026"], "canonical_name": "TTT complex", "definition": "A protein complex responsible for the stabilisation of protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex can also be found as part of the ASTRA complex (GO:0070209). [GOC:lnp, PMID:20810650, PMID:22505622, PMID:28827813]"}
{"concept_id": "C4690818", "aliases": [], "types": ["T039"], "canonical_name": "regulation of placenta blood vessel development", "definition": "Any process that modulates the frequency, rate or extent of placenta blood vessel development. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453]"}
{"concept_id": "C4690819", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of placenta blood vessel development", "definition": "Any process that activates or increases the frequency, rate or extent of placenta blood vessel development. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453]"}
{"concept_id": "C4690820", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of placenta blood vessel development", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453]"}
{"concept_id": "C4690821", "aliases": [], "types": ["T039"], "canonical_name": "regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly", "definition": "Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly. [GOC:vw, PMID:29343550]"}
{"concept_id": "C4690822", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly. [GOC:vw, PMID:29343550]"}
{"concept_id": "C4690823", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly. [GOC:vw, PMID:29343550]"}
{"concept_id": "C4690824", "aliases": [], "types": ["T026"], "canonical_name": "mitotic actomyosin contractile ring", "definition": "A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis. [GOC:vw, PMID:27505246]"}
{"concept_id": "C4690825", "aliases": [], "types": ["T026"], "canonical_name": "meiotic actomyosin contractile ring", "definition": "A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the meiotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the meiotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In fungal cells, the meiotic contractile ring forms beneath the plasma membrane of the prospore envelope in preparation for completing cytokinesis. [GOC:vw, PMID:22526418]"}
{"concept_id": "C4690827", "aliases": [], "types": ["T043"], "canonical_name": "hippocampal neuron apoptotic process", "definition": "Any apoptotic process that occurs in a hippocampal neuron. [GOC:sl, PMID:18940801]"}
{"concept_id": "C4690828", "aliases": [], "types": ["T043"], "canonical_name": "regulation of hippocampal neuron apoptotic process", "definition": "Any process that modulates the occurrence or rate of cell death by apoptotic process in hippocampal neurons. [GOC:sl, PMID:18940801]"}
{"concept_id": "C4690829", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of hippocampal neuron apoptotic process", "definition": "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons. [GOC:sl, PMID:18940801]"}
{"concept_id": "C4690830", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of hippocampal neuron apoptotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons. [GOC:sl, PMID:18940801]"}
{"concept_id": "C4690831", "aliases": [], "types": ["T026"], "canonical_name": "nucleus leading edge", "definition": "The area of a motile nucleus closest to the direction of movement. [GOC:al, GOC:mah, GOC:vw, PMID:15030757, PMID:24335254]"}
{"concept_id": "C4690832", "aliases": [], "types": ["T026"], "canonical_name": "horsetail nucleus leading edge"}
{"concept_id": "C4690833", "aliases": [], "types": ["T026"], "canonical_name": "nucleus lagging edge", "definition": "The area of a motile nucleus furthest from the direction of movement. [GOC:kmv, PMID:24335254]"}
{"concept_id": "C4690834", "aliases": ["polyphosphate signaling"], "types": ["T043"], "canonical_name": "polyphosphate-mediated signaling", "definition": "Any process that mediates the transfer of information from one cell to another using polyphosphate as the signal. [GOC:rjd, PMID:27519410, PMID:28584190]"}
{"concept_id": "C4690835", "aliases": [], "types": ["T043"], "canonical_name": "cellular detoxification of aldehyde", "definition": "Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:vw, PMID:25656103]"}
{"concept_id": "C4690836", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to aldehyde", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus. [GOC:vw, PMID:25656103]"}
{"concept_id": "C4690837", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium import into the mitochondrion", "definition": "Any process that modulates the frequency, rate or extent of calcium import into the mitochondrion. [GOC:sl, PMID:24085037]"}
{"concept_id": "C4690838", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of calcium import into the mitochondrion", "definition": "Any process that activates or increases the frequency, rate or extent of calcium import into the mitochondrion. [GOC:sl, PMID:24085037]"}
{"concept_id": "C4690839", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of calcium import into the mitochondrion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into the mitochondrion. [GOC:sl, PMID:24085037]"}
{"concept_id": "C4690840", "aliases": [], "types": ["T043"], "canonical_name": "spindle pole body separation", "definition": "The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble. [GOC:vw]"}
{"concept_id": "C4690841", "aliases": [], "types": ["T043"], "canonical_name": "L-valine transmembrane import into vacuole", "definition": "The directed movement of L-valine into the vacuole across the vacuolar membrane. [GOC:al, PMID:20944394]"}
{"concept_id": "C4690842", "aliases": ["RuBisCO assembly"], "types": ["T043"], "canonical_name": "ribulose bisphosphate carboxylase complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a ribulose bisphosphate carboxylase complex. [GOC:krc, GOC:tb, PMID:29396988, PMID:29589905]"}
{"concept_id": "C4690843", "aliases": ["RNA polymerase II termination complex location", "TXT complex location", "TXT complex"], "types": ["T026"], "canonical_name": "RNA polymerase II termination complex", "definition": "A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end. [GOC:lnp, PMID:23200120, PMID:25722373]"}
{"concept_id": "C4690844", "aliases": [], "types": ["T045"], "canonical_name": "mRNA alternative polyadenylation", "definition": "The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals). [GOC:ans, PMID:28453393, PMID:29276085]"}
{"concept_id": "C4690845", "aliases": [], "types": ["T043"], "canonical_name": "mRNA cleavage and polyadenylation specificity factor complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the mRNA cleavage and polyadenylation specificity factor complex. [GOC:mah, PMID:27401558]"}
{"concept_id": "C4690846", "aliases": [], "types": ["T043"], "canonical_name": "plasma membrane bounded cell projection morphogenesis", "definition": "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. [GOC:krc]"}
{"concept_id": "C4690847", "aliases": [], "types": ["T043"], "canonical_name": "regulation of macrophage proliferation", "definition": "Any process that modulates the frequency, rate or extent of macrophage proliferation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4690848", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of macrophage proliferation", "definition": "Any process that activates or increases the frequency, rate or extent of macrophage proliferation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4690849", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of macrophage proliferation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage proliferation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4690850", "aliases": [], "types": ["T026"], "canonical_name": "stereocilium shaft", "definition": "The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle. [GOC:krc, PMID:20170899]"}
{"concept_id": "C4690851", "aliases": ["stereocilium taper"], "types": ["T026"], "canonical_name": "stereocilium base", "definition": "The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium. [GOC:krc, PMID:20170899]"}
{"concept_id": "C4690852", "aliases": [], "types": ["T043"], "canonical_name": "stereocilium maintenance", "definition": "The organization process that preserves a stereocilium in a stable functional or structural state. [GOC:krc, PMID:27693694]"}
{"concept_id": "C4690853", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein localization to medial cortical node", "definition": "Any process that modulates the frequency, rate or extent of protein localization to a medial cortical node. [PMID:19474789]"}
{"concept_id": "C4690854", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein localization to medial cortical node", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to a medial cortical node. [PMID:19474789]"}
{"concept_id": "C4690855", "aliases": [], "types": ["T044"], "canonical_name": "U6 snRNA (adenine-(43)-N(6))-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(43) in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine(43) in U6 snRNA. [PMID:28525753]"}
{"concept_id": "C4690856", "aliases": [], "types": ["T045"], "canonical_name": "snRNA (adenine-N6)-methylation", "definition": "The posttranscriptional N6-methylation of an adenine residue in an snRNA molecule. [PMID:28525753]"}
{"concept_id": "C4690857", "aliases": [], "types": ["T044"], "canonical_name": "ribitol beta-1,4-xylosyltransferase activity", "definition": "Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R. [PMID:27733679]"}
{"concept_id": "C4690858", "aliases": ["small intestine transit", "small bowel transit"], "types": ["T038"], "canonical_name": "small intestinal transit", "definition": "Migration of ingested material along the length of the small intestine. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690859", "aliases": ["colonic transit", "colon transit", "large bowel transit", "large intestine transit"], "types": ["T040"], "canonical_name": "large intestinal transit", "definition": "Migration of ingested material along the length of the large intestine. [GOC:sl, PMID:28157109]"}
{"concept_id": "C4690860", "aliases": ["regulation of small intestine transit", "regulation of small bowel transit"], "types": ["T038"], "canonical_name": "regulation of small intestinal transit", "definition": "Any process that modulates the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690861", "aliases": ["positive regulation of small intestine transit", "positive regulation of small bowel transit"], "types": ["T038"], "canonical_name": "positive regulation of small intestinal transit", "definition": "Any process that increases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690862", "aliases": ["negative regulation of small intestine transit", "negative regulation of small bowel transit"], "types": ["T038"], "canonical_name": "negative regulation of small intestinal transit", "definition": "Any process that decreases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690863", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of gastric emptying", "definition": "Any process that decreases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690864", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of gastric emptying", "definition": "Any process that increases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690865", "aliases": [], "types": ["T042"], "canonical_name": "stomach smooth muscle contraction", "definition": "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs throughout the length of the stomach. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690866", "aliases": [], "types": ["T042"], "canonical_name": "stomach pylorus smooth muscle contraction", "definition": "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the most distal part of the stomach. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690867", "aliases": ["antrum smooth muscle contraction"], "types": ["T039"], "canonical_name": "pyloric antrum smooth muscle contraction", "definition": "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the widest part of the pylorus that is continuous with the body of the stomach. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690868", "aliases": [], "types": ["T042"], "canonical_name": "pyloric canal smooth muscle contraction", "definition": "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal part of the pylorus between the pyloric antrum and the pyloric sphincter. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690869", "aliases": [], "types": ["T038"], "canonical_name": "pyloric sphincter smooth muscle contraction", "definition": "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the narrowest part of the pylorus that separates the stomach from the duodenum. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690870", "aliases": [], "types": ["T039"], "canonical_name": "regulation of stomach fundus smooth muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of any stomach fundus smooth muscle contraction. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690871", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of stomach fundus smooth muscle contraction", "definition": "Any process that increases the frequency, rate or extent of any stomach fundus smooth muscle contraction. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690872", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of stomach fundus smooth muscle contraction", "definition": "Any process that decreases the frequency, rate or extent of any stomach fundus smooth muscle contraction. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690873", "aliases": [], "types": ["T039"], "canonical_name": "regulation of pyloric antrum smooth muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of any pyloric antrum smooth muscle contraction. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690874", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of pyloric antrum smooth muscle contraction", "definition": "Any process that increases the frequency, rate or extent of any pyloric antrum smooth muscle contraction. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690875", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of pyloric antrum smooth muscle contraction", "definition": "Any process that decreases the frequency, rate or extent of any pyloric antrum smooth muscle contraction. [GOC:sl, PMID:15890336]"}
{"concept_id": "C4690876", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endocardial cushion cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4690877", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endocardial cushion cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of endocardial cushion cell differentiation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4690878", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endocardial cushion cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of endocardial cushion cell differentiation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4690879", "aliases": ["blood vessel anastomosis"], "types": ["T038"], "canonical_name": "angiogenic sprout fusion", "definition": "The connection of an angiogenic sprout to another vessel or sprout during the formation of vascular networks by sprouting angiogenesis. [GOC:cvs, PMID:28264837]"}
{"concept_id": "C4690880", "aliases": ["cell adhesion involved in blood vessel anastomosis"], "types": ["T043"], "canonical_name": "cell adhesion involved in sprouting angiogenesis", "definition": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the formation of a blood vessel network. [GOC:cvs, PMID:28264837]"}
{"concept_id": "C4690881", "aliases": [], "types": ["T043"], "canonical_name": "cell adhesion involved in vascular anastomosis"}
{"concept_id": "C4690891", "aliases": [], "types": ["T043"], "canonical_name": "endothelial tip cell filopodium assembly", "definition": "The assembly of a filopodium, a thin, stiff protrusion extended by the endothelial tip cell of a vascular sprout. [GOC:cvs, PMID:28264837]"}
{"concept_id": "C4690892", "aliases": ["retrotransposon integration"], "types": ["T045"], "canonical_name": "transposon integration involved in RNA-mediated transposition", "definition": "Any transposon integration that contributes to a process of RNA-mediated transposition. [GOC:mah, PMID:26358720]"}
{"concept_id": "C4690893", "aliases": [], "types": ["T044"], "canonical_name": "(3S)-(+)-asterisca-2(9),6-diene synthase activity", "definition": "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene. [PMID:27862766]"}
{"concept_id": "C4690894", "aliases": [], "types": ["T044"], "canonical_name": "asterisca-2(9),6-diene synthase activity"}
{"concept_id": "C4690895", "aliases": [], "types": ["T044"], "canonical_name": "jasmonic acid hydrolase", "definition": "Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid. [PMID:28559313, PMID:28760569]"}
{"concept_id": "C4690896", "aliases": [], "types": ["T044"], "canonical_name": "2-oxoglutarate dioxygenase"}
{"concept_id": "C4690897", "aliases": [], "types": ["T044"], "canonical_name": "crotonyl-CoA hydratase activity", "definition": "Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. [PMID:28803779]"}
{"concept_id": "C4690898", "aliases": [], "types": ["T044"], "canonical_name": "regulation of peptidyl-lysine crotonylation", "definition": "Any process that modulates the frequency, rate or extent of crotonylation of a lysine residue in a protein. [PMID:28803779]"}
{"concept_id": "C4690899", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of peptidyl-lysine crotonylation", "definition": "Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein. [PMID:28803779]"}
{"concept_id": "C4690900", "aliases": ["VICS", "vacuole-phagophore contact site", "vacuole-IM contact site"], "types": ["T026"], "canonical_name": "vacuole-isolation membrane contact site", "definition": "An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome. [PMID:23549786]"}
{"concept_id": "C4690901", "aliases": ["glycosylphosphatidylinositol-mannosyltransferase II complex location"], "types": ["T026"], "canonical_name": "glycosylphosphatidylinositol-mannosyltransferase II complex", "definition": "A protein complex that is involved in the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. In yeast S. cerevisiae this complex consists of GPI18p and PGA1p. [GOC:bhm, PMID:17615295]"}
{"concept_id": "C4690902", "aliases": ["procentriole replication complex location"], "types": ["T026"], "canonical_name": "procentriole replication complex", "definition": "A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates. [GOC:bhm, PMID:17576815, PMID:18207742, PMID:21059844, PMID:22020124, PMID:24997597]"}
{"concept_id": "C4690903", "aliases": [], "types": ["T026"], "canonical_name": "bacterial-type flagellum motor", "definition": "A transmembrane complex embedded in the cytoplasmic membrane which is the motor force, or torque, generator of the bacterial-type flagellum. The motor consists of a membrane-anchored rotor complex surrounded by one or more stator complexes in the cytoplasmic membrane. The stator consists of a hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. Examples are the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. The rotor complex consists of a membrane-anchored ring and the motor switch complex, which controls the direction of flagellar rotation. [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856]"}
{"concept_id": "C4690904", "aliases": ["bacterial-type flagellum motor force generator complex", "bacterial-type flagellum torque generator complex location", "bacterial-type flagellum motor force generator complex location", "bacterial-type flagellum stator complex location", "bacterial-type flagellum torque generator complex"], "types": ["T026"], "canonical_name": "bacterial-type flagellum stator complex", "definition": "A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. [GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856]"}
{"concept_id": "C4690905", "aliases": ["bacterial-type flagellum export apparatus"], "types": ["T026"], "canonical_name": "bacterial-type flagellum secretion apparatus", "definition": "A part of the bacterial-type flagellum that is located at the cytoplasmic side of the MS ring and composed of six membrane proteins (FlhA, FlhB, FliP, FliQ, FliR, and FliO, or orthologs thereof) and three soluble proteins (FliI, FliH, and FliJ, or orthologs thereof) in the cytoplasm. It is responsible for secretion of flagellar type III protein substrates, including the proteins of the flagellar rod, hook, and filament. [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856]"}
{"concept_id": "C4690906", "aliases": ["subdistal appendage of mother centriole", "subdistal appendage of basal body", "subdistal appendage of centriole"], "types": ["T026"], "canonical_name": "centriolar subdistal appendage", "definition": "A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68. [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092]"}
{"concept_id": "C4690907", "aliases": ["actomyosin contractile ring, proximal layer"], "types": ["T026"], "canonical_name": "mitotic actomyosin contractile ring, proximal layer", "definition": "The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located. [GOC:krc, GOC:vw, PMID:28914606]"}
{"concept_id": "C4690908", "aliases": ["actomyosin contractile ring, intermediate layer"], "types": ["T026"], "canonical_name": "mitotic actomyosin contractile ring, intermediate layer", "definition": "The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer. [GOC:krc, GOC:vw, PMID:28914606]"}
{"concept_id": "C4690909", "aliases": ["actomyosin contractile ring, distal actin filament layer"], "types": ["T026"], "canonical_name": "mitotic actomyosin contractile ring, distal actin filament layer", "definition": "The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to. [GOC:krc, GOC:vw, PMID:28914606]"}
{"concept_id": "C4690910", "aliases": ["bacterial-type flagellum rotor complex location"], "types": ["T026"], "canonical_name": "bacterial-type flagellum rotor complex", "definition": "The rotor complex of the bacterial-type flagellum consists of a membrane-anchored ring and the motor switch complex, which participates in the conversion of proton/Na+ energy into the mechanical work of rotation and controls the direction of flagellar rotation. [GOC:cilia, PMID:10572114, PMID:12624192, PMID:25251856]"}
{"concept_id": "C4690911", "aliases": ["DNA-3'pp5'G guanylate hydrolase"], "types": ["T044"], "canonical_name": "DNA-3'-diphospho-5'-guanosine diphosphatase", "definition": "Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H(2)O <=> (DNA)-3'-phosphate + GMP. [PMID:26007660, RHEA:52140]"}
{"concept_id": "C4690912", "aliases": [], "types": ["T045"], "canonical_name": "mitotic telomere clustering and tethering at nuclear periphery", "definition": "The process in which the telomeres are gathered together to a small number of foci per chromosome (usually one per chromosome or fewer), and moved to and tethered at the nuclear periphery, as part of a mitotic cell cycle. [PMID:25778919]"}
{"concept_id": "C4690913", "aliases": ["mitotic telomere clustering during interphase"], "types": ["T043"], "canonical_name": "interphase mitotic telomere clustering", "definition": "The process whereby the mitotic telomeres are gathered together during, or prior to, attachment to the nuclear envelope. [PMID:25778919]"}
{"concept_id": "C4690914", "aliases": [], "types": ["T026"], "canonical_name": "neuron projection cytoplasm", "definition": "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. [GOC:ha]"}
{"concept_id": "C4690915", "aliases": [], "types": ["T043"], "canonical_name": "UDP-glucose transmembrane transport into endoplasmic reticulum", "definition": "The directed movement of UDP-glucose from cytosol to endoplasmic reticulum. [PMID:27587357]"}
{"concept_id": "C4690916", "aliases": ["protein localization by the NVT pathway", "protein localization by the Nbr1-mediated vacuolar targeting pathway"], "types": ["T043"], "canonical_name": "cytoplasm to vacuole transport by the NVT pathway", "definition": "A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe. [PMID:26365378]"}
{"concept_id": "C4690917", "aliases": ["Sm-like protein family complex location"], "types": ["T026"], "canonical_name": "Sm-like protein family complex", "definition": "A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles. [GOC:bhm, GOC:krc, PMID:19121818, PMID:27627834]"}
{"concept_id": "C4690918", "aliases": ["Lsm2-8 complex location"], "types": ["T026"], "canonical_name": "Lsm2-8 complex", "definition": "A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus. [GOC:bhm, GOC:krc, PMID:19121818, PMID:23221597, PMID:27627834, PMID:28768202]"}
{"concept_id": "C4690919", "aliases": [], "types": ["T044"], "canonical_name": "glucagon processing", "definition": "The formation of mature glucagon by proteolysis of the precursor proglucagon. [PMID:28719828]"}
{"concept_id": "C4690920", "aliases": ["T cell meandering search"], "types": ["T043"], "canonical_name": "T cell meandering migration", "definition": "The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs). [GOC:add, GOC:krc, PMID:25083865]"}
{"concept_id": "C4690921", "aliases": [], "types": ["T043"], "canonical_name": "lymph node surveillance"}
{"concept_id": "C4690922", "aliases": [], "types": ["T026"], "canonical_name": "flagella connector", "definition": "A mobile transmembrane junction at the tip of the flagellum of some kinetoplastid species linking the tip of a new growing flagellum to an older flagellum. [PMID:11641501, PMID:15075226, PMID:16954145, PMID:26820516]"}
{"concept_id": "C4690923", "aliases": ["FAZ"], "types": ["T026"], "canonical_name": "flagellum attachment zone", "definition": "A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species. [PMID:10361731, PMID:16414276, PMID:17945531, PMID:20541452, PMID:25972344, PMID:2606941, PMID:26746239, PMID:26776656]"}
{"concept_id": "C4690924", "aliases": ["kinetoplastid flagellar hook complex location", "kinetoplastid flagellar hook complex"], "types": ["T026"], "canonical_name": "bilobe structure", "definition": "A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone). [PMID:22327007, PMID:22445359, PMID:26540076]"}
{"concept_id": "C4690925", "aliases": ["prolactin metabolism"], "types": ["T044"], "canonical_name": "prolactin metabolic process", "definition": "The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals. [PMID:11015620]"}
{"concept_id": "C4690926", "aliases": ["E1 complex", "ubiquitin activating enzyme complex location", "E1 complex location"], "types": ["T026"], "canonical_name": "ubiquitin activating enzyme complex", "definition": "A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. [GOC:lnp, PMID:9545234]"}
{"concept_id": "C4690927", "aliases": ["LMA1 complex location", "GATE-16 complex location", "GATE-16 complex", "LMA1 complex", "membrane fusion priming complex location"], "types": ["T026"], "canonical_name": "membrane fusion priming complex", "definition": "A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes. [GOC:lnp, PMID:9015301]"}
{"concept_id": "C4690928", "aliases": ["PNGase complex location"], "types": ["T026"], "canonical_name": "PNGase complex", "definition": "A protein complex responsible for the catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. [GOC:lnp, PMID:15964983, PMID:16249333]"}
{"concept_id": "C4690929", "aliases": [], "types": ["T040"], "canonical_name": "response to copper ion starvation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of copper ion. [GOC:sl, PMID:24024382]"}
{"concept_id": "C4690930", "aliases": [], "types": ["T043"], "canonical_name": "response to zinc ion starvation", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of zinc ion. [GOC:sl, PMID:24024381]"}
{"concept_id": "C4690931", "aliases": ["positive regulation of apoptotic process in bone marrow", "positive regulation of programmed cell death, bone marrow cells", "upregulation of apoptosis in bone marrow", "positive regulation of bone marrow cell programmed cell death by apoptosis", "positive regulation of programmed cell death of bone marrow cells by apoptosis", "up regulation of apoptosis in bone marrow", "positive regulation of killing of bone marrow cells", "positive regulation of bone marrow cell apoptosis", "up-regulation of apoptosis in bone marrow"], "types": ["T043"], "canonical_name": "positive regulation of apoptotic process in bone marrow cell", "definition": "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in the bone marrow. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27908889]"}
{"concept_id": "C4690932", "aliases": [], "types": ["T043"], "canonical_name": "activation of apoptosis in bone marrow"}
{"concept_id": "C4690933", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of apoptosis in bone marrow"}
{"concept_id": "C4690934", "aliases": ["down regulation of actin cortical patch assembly", "down-regulation of actin cortical patch assembly", "downregulation of actin cortical patch assembly"], "types": ["T043"], "canonical_name": "negative regulation of actin cortical patch assembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin cortical patches. [PMID:19962315]"}
{"concept_id": "C4690935", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of actin cortical patch assembly"}
{"concept_id": "C4690936", "aliases": ["proximal part of axoneme"], "types": ["T026"], "canonical_name": "proximal portion of axoneme", "definition": "The portion of the axoneme that is close to the base of the cilium. [GOC:krc]"}
{"concept_id": "C4690937", "aliases": ["distal part of axoneme"], "types": ["T026"], "canonical_name": "distal portion of axoneme", "definition": "The portion of the axoneme that is close to the tip of the cilium. [GOC:krc]"}
{"concept_id": "C4690938", "aliases": ["dUMP-kinase activity", "deoxyuridine monophosphate kinase activity", "ATP:dUMP phosphotransferase activity"], "types": ["T044"], "canonical_name": "dUMP kinase activity", "definition": "Catalysis of the reaction: ATP + dUMP = ADP + dUDP. [PMID:3010881, RHEA:30655]"}
{"concept_id": "C4690939", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity", "definition": "Any process that activates or increases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. [PMID:23407971]"}
{"concept_id": "C4690940", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. [PMID:17097615]"}
{"concept_id": "C4690941", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. [PMID:17097615]"}
{"concept_id": "C4690942", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. [PMID:17097615]"}
{"concept_id": "C4690943", "aliases": [], "types": ["T044"], "canonical_name": "regulation of ecdysone receptor-mediated signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the activity of any ecdysone receptor-mediated signaling pathway. [GOC:ha, PMID:23072462]"}
{"concept_id": "C4690944", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ecdysone receptor-mediated signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of any ecdysone receptor-mediated signaling pathway. [GOC:ha, PMID:23072462]"}
{"concept_id": "C4690945", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ecdysone receptor-mediated signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of any ecdysone receptor-mediated signaling pathway. [GOC:ha, PMID:23072462]"}
{"concept_id": "C4690946", "aliases": ["protein localisation to basal ectoplasmic specialization", "protein localisation in basal ectoplasmic specialization", "protein localization in basal ectoplasmic specialization"], "types": ["T043"], "canonical_name": "protein localization to basal ectoplasmic specialization", "definition": "A process in which a protein is transported to, or maintained in, a location within a basal ectoplasmic specialization. [PMID:22872576]"}
{"concept_id": "C4690947", "aliases": ["3-O-sulfogalactosylceramide binding", "SM4 binding", "sulfated galactocerebroside binding"], "types": ["T044"], "canonical_name": "sulfatide binding", "definition": "Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group. [GOC:krc, PMID:21525289, PMID:22619219, PMID:22977233, PMID:23574804, PMID:29497057, PMID:3549017, Wikipedia:Sulfatide]"}
{"concept_id": "C4690948", "aliases": [], "types": ["T044"], "canonical_name": "Formylglycine-generating oxidase activity", "definition": "Catalysis of the reaction: A [sulfatase]-L-cysteine + O(2) + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H(2)O. [EC:1.8.3.7, RHEA:51152]"}
{"concept_id": "C4690949", "aliases": ["host centrosome"], "types": ["T026"], "canonical_name": "host cell centrosome", "definition": "A structure in a host cell comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [ISBN:0198547684]"}
{"concept_id": "C4690950", "aliases": ["host peroxisome"], "types": ["T026"], "canonical_name": "host cell peroxisome", "definition": "A small host cell organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [PMID:9302272]"}
{"concept_id": "C4690951", "aliases": ["regulation of mitotic contractile actomyosin ring disassembly", "regulation of mitotic cytokinetic ring disassembly", "regulation of mitotic constriction ring disassembly", "regulation of mitotic CAR disassembly", "regulation of mitotic actomyosin ring disassembly"], "types": ["T043"], "canonical_name": "regulation of mitotic actomyosin contractile ring disassembly", "definition": "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring disassembly. [PMID:19109423]"}
{"concept_id": "C4690952", "aliases": ["positive regulation of mitotic actomyosin ring disassembly", "positive regulation of mitotic contractile actomyosin ring disassembly", "positive regulation of mitotic constriction ring disassembly", "positive regulation of mitotic CAR disassembly", "positive regulation of mitotic cytokinetic ring disassembly"], "types": ["T043"], "canonical_name": "positive regulation of mitotic actomyosin contractile ring disassembly", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring disassembly. [PMID:19109423]"}
{"concept_id": "C4690953", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent outer dynein arm binding", "definition": "Binding to an outer dynein arm in the presence of calcium. [GOC:krc, PMID:18620543]"}
{"concept_id": "C4690954", "aliases": [], "types": ["T044"], "canonical_name": "calcium-dependent carbohydrate binding", "definition": "Binding to a carbohydrate in the presence of calcium. [PMID:25912189]"}
{"concept_id": "C4690955", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ERBB4 signaling pathway", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB4 signaling pathway. [PMID:15219672]"}
{"concept_id": "C4690956", "aliases": ["Mlc1p-Iqg1p-Hof1p complex location", "Mlc1p-Iqg1p-Hof1p complex", "MIH complex location"], "types": ["T026"], "canonical_name": "MIH complex", "definition": "A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins. [GOC:rn, PMID:24413167, PMID:24895401]"}
{"concept_id": "C4690957", "aliases": ["apical polarity complex", "PAR polarity complex location", "apical polarity complex location"], "types": ["T026"], "canonical_name": "PAR polarity complex", "definition": "A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. [GOC:lnp, PMID:11113154, PMID:18005931, PMID:22500799, PMID:28682236]"}
{"concept_id": "C4690958", "aliases": ["BEM1-CDC24-CLA4 complex location"], "types": ["T026"], "canonical_name": "BEM1-CDC24-CLA4 complex"}
{"concept_id": "C4690959", "aliases": ["Cdc42p GEF-PAK complex location"], "types": ["T026"], "canonical_name": "Cdc42p GEF-PAK complex"}
{"concept_id": "C4690960", "aliases": [], "types": ["T026"], "canonical_name": "PAR3-PAR6-atypical PKC"}
{"concept_id": "C4690961", "aliases": [], "types": ["T026"], "canonical_name": "PAR3/PAR6/aPKC"}
{"concept_id": "C4690962", "aliases": ["PAR6-PAR3-aPKC complex location"], "types": ["T026"], "canonical_name": "PAR6-PAR3-aPKC complex"}
{"concept_id": "C4690963", "aliases": ["positive regulation of collagen catabolism", "positive regulation of collagen breakdown", "up regulation of collagen catabolic process", "positive regulation of collagen degradation", "upregulation of collagen catabolic process", "up-regulation of collagen catabolic process"], "types": ["T044"], "canonical_name": "positive regulation of collagen catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. [GOC:dph, GOC:tb]"}
{"concept_id": "C4690964", "aliases": [], "types": ["T044"], "canonical_name": "activation of collagen catabolic process"}
{"concept_id": "C4690965", "aliases": [], "types": ["T044"], "canonical_name": "rRNA pseudouridine synthase activity", "definition": "Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [PMID:28432181]"}
{"concept_id": "C4690966", "aliases": [], "types": ["T044"], "canonical_name": "16S rRNA pseudouridine(516) synthase"}
{"concept_id": "C4690967", "aliases": [], "types": ["T044"], "canonical_name": "21S rRNA pseudouridine(2819) synthase"}
{"concept_id": "C4690968", "aliases": [], "types": ["T045"], "canonical_name": "23S rRNA pseudouridine(1911/1915/1917) synthase"}
{"concept_id": "C4690969", "aliases": [], "types": ["T044"], "canonical_name": "23S rRNA pseudouridine(2457) synthase"}
{"concept_id": "C4690970", "aliases": [], "types": ["T044"], "canonical_name": "23S rRNA pseudouridine(2604) synthase"}
{"concept_id": "C4690971", "aliases": [], "types": ["T045"], "canonical_name": "23S rRNA pseudouridine(2605) synthase"}
{"concept_id": "C4690972", "aliases": [], "types": ["T044"], "canonical_name": "23S rRNA pseudouridine(746) synthase"}
{"concept_id": "C4690973", "aliases": [], "types": ["T044"], "canonical_name": "23S rRNA pseudouridine(955/2504/2580) synthase"}
{"concept_id": "C4690974", "aliases": ["intraflagellar transport particle A binding", "intraciliary transport complex A binding", "intraflagellar transport complex A binding"], "types": ["T044"], "canonical_name": "intraciliary transport particle A binding", "definition": "Binding to an intraciliary transport particle A (IFT A) complex. [PMID:20889716]"}
{"concept_id": "C4690975", "aliases": [], "types": ["T044"], "canonical_name": "IFT A complex binding"}
{"concept_id": "C4690976", "aliases": ["regulation of CIT"], "types": ["T040"], "canonical_name": "regulation of cold-induced thermogenesis", "definition": "Any process that modulates the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]"}
{"concept_id": "C4690977", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of cold-induced thermogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]"}
{"concept_id": "C4690978", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of CIT"}
{"concept_id": "C4690979", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cold-induced thermogenesis", "definition": "Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis. [PMID:27876809]"}
{"concept_id": "C4690980", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of CIT"}
{"concept_id": "C4690981", "aliases": [], "types": ["T039"], "canonical_name": "conidium germination", "definition": "The physiological and developmental changes that occur in a conidium or asexual spore following release from dormancy up to the earliest signs of development such as swelling of conidia, adhesion and nuclear decondensation followed by hyphal growth several hours later. In many genera of plant pathogenic fungi (e.g. Magnaporthe, Colletotrichum, Ustilago), swelling of the hyphal tips to form appressorium, metabolic activities including respiration, RNA and protein synthesis and trehalose breakdown and changes in cell wall composition can be detected in conidium germination. [DOI:10.1128/9781555815523.ch10, PMID:10835388, PMID:11377860, PMID:17950638, PMID:18944978, PMID:25063657, PMID:27355215, PMID:9529886]"}
{"concept_id": "C4690982", "aliases": [], "types": ["T040"], "canonical_name": "perithecium development", "definition": "The process whose specific outcome is the progression of a perithecium over time, from its formation to the mature structure. Peritheicum is a flask-shaped fruiting body of certain molds and ascomycetous fungi having a pore for the escape of spores. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck. [DOI:10.1007/978-3-642-00286-1_2, PMID:125266, PMID:19547974, PMID:20739093, PMID:25311923]"}
{"concept_id": "C4690983", "aliases": [], "types": ["T040"], "canonical_name": "protoperithecium formation", "definition": "The process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium. [DOI:10.1007/978-3-642-00286-1_2, PMID:125266, PMID:20739093, PMID:25311923, PMID:4410944, PMID:6235211, PMID:6235212]"}
{"concept_id": "C4690984", "aliases": [], "types": ["T043"], "canonical_name": "plus-end-directed endosome transport along mitotic spindle midzone microtubule", "definition": "The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination. [PMID:24803650, PMID:25706234]"}
{"concept_id": "C4690985", "aliases": [], "types": ["T043"], "canonical_name": "contractile vacuole tethering involved in discharge", "definition": "The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. [PMID:22323285]"}
{"concept_id": "C4690986", "aliases": [], "types": ["T043"], "canonical_name": "contractile vacuole tethering to plasma membrane"}
{"concept_id": "C4690987", "aliases": ["contractile vacuole detethering from plasma membrane"], "types": ["T043"], "canonical_name": "contractile vacuole dissociation from plasma membrane", "definition": "The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network. [PMID:22323285]"}
{"concept_id": "C4690988", "aliases": [], "types": ["T043"], "canonical_name": "establishment of contractile vacuole localization"}
{"concept_id": "C4690989", "aliases": [], "types": ["T043"], "canonical_name": "pore formation during contractile vacuole discharge", "definition": "The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes. [PMID:22323285, Wikipedia:Exocytosis]"}
{"concept_id": "C4690990", "aliases": [], "types": ["T043"], "canonical_name": "exocytic process", "definition": "The cellular processes that contribute to exocytosis. [Wikipedia:Exocytosis]"}
{"concept_id": "C4690991", "aliases": [], "types": ["T044"], "canonical_name": "modification-dependent protein binding", "definition": "Binding to a protein upon post-translation modification of the target protein. [PMID:26060076]"}
{"concept_id": "C4690992", "aliases": [], "types": ["T044"], "canonical_name": "modified protein binding"}
{"concept_id": "C4690993", "aliases": [], "types": ["T044"], "canonical_name": "phosphorylation-dependent protein binding", "definition": "Binding to a protein upon phosphorylation of the target protein. [PMID:26060076]"}
{"concept_id": "C4690994", "aliases": [], "types": ["T044"], "canonical_name": "glycosylation-dependent protein binding", "definition": "Binding to a protein upon glycosylation of the target protein. [PMID:26060076]"}
{"concept_id": "C4690995", "aliases": [], "types": ["T044"], "canonical_name": "acetylation-dependent protein binding", "definition": "Binding to a protein upon acetylation of the target protein. [PMID:26060076]"}
{"concept_id": "C4690996", "aliases": [], "types": ["T044"], "canonical_name": "methylation-dependent protein binding", "definition": "Binding to a protein upon methylation of the target protein. [PMID:26060076]"}
{"concept_id": "C4690997", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitination-like modification-dependent protein binding", "definition": "Binding to a protein upon modification by a ubiquitin-like protein of the target protein. [PMID:26060076]"}
{"concept_id": "C4690998", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin-dependent protein binding", "definition": "Binding to a protein upon ubiquitination of the target protein. [PMID:26060076]"}
{"concept_id": "C4690999", "aliases": [], "types": ["T044"], "canonical_name": "sumo-dependent protein binding", "definition": "Binding to a protein upon sumoylation of the target protein. [PMID:26060076]"}
{"concept_id": "C4691000", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion in response to extracellular stimulus", "definition": "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus. [PMID:14996911]"}
{"concept_id": "C4691001", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial polycistronic RNA processing", "definition": "The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs. [PMID:20211597]"}
{"concept_id": "C4691002", "aliases": [], "types": ["T043"], "canonical_name": "cellular detoxification of methylglyoxal", "definition": "Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal. [PMID:15042280]"}
{"concept_id": "C4691003", "aliases": ["lipid body formation", "lipid particle formation", "adiposome formation"], "types": ["T043"], "canonical_name": "lipid droplet formation", "definition": "A process that results in the assembly, arrangement of constituent parts of a lipid droplet. [PMID:28011631]"}
{"concept_id": "C4691004", "aliases": ["adiposome localization to FSM membrane leading edge", "lipid body localization to FSM membrane leading edge", "adiposome localization to ascospore-type prospore membrane leading edge", "lipid body localization to ascospore-type prospore membrane leading edge", "lipid particle localization to ascospore-type prospore membrane leading edge", "lipid particle localization to FSM membrane leading edge"], "types": ["T039"], "canonical_name": "lipid droplet localization to prospore membrane leading edge", "definition": "Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge. [PMID:28011631]"}
{"concept_id": "C4691005", "aliases": [], "types": ["T039"], "canonical_name": "adiposome localization to forespore membrane leading edge"}
{"concept_id": "C4691006", "aliases": [], "types": ["T039"], "canonical_name": "lipid body localization to forespore membrane leading edge"}
{"concept_id": "C4691007", "aliases": [], "types": ["T039"], "canonical_name": "lipid particle localization to forespore membrane leading edge"}
{"concept_id": "C4691008", "aliases": ["manganese ion export from cell"], "types": ["T044"], "canonical_name": "manganese ion export across plasma membrane", "definition": "The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region. [PMID:25319704]"}
{"concept_id": "C4691009", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endocardial cushion to mesenchymal transition", "definition": "Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427]"}
{"concept_id": "C4691010", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of endocardial cushion to mesenchymal transition", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427]"}
{"concept_id": "C4691011", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of endocardial cushion to mesenchymal transition", "definition": "Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427]"}
{"concept_id": "C4691012", "aliases": ["cellular response to oxidized low-density lipoprotein particle stimulus", "cellular response to oxLDL particle stimulus", "cellular response to oxidized LDL particle stimulus", "cellular response to ox-LDL particle stimulus", "cellular response to oxidised LDL particle stimulus"], "types": ["T043"], "canonical_name": "cellular response to oxidised low-density lipoprotein particle stimulus", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus. [GOC:aruk, GOC:BHF, PMID:20037584, PMID:27607416]"}
{"concept_id": "C4691013", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial gene expression", "definition": "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. [PMID:27058308]"}
{"concept_id": "C4691014", "aliases": [], "types": ["T043"], "canonical_name": "organelle localization by membrane tethering", "definition": "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. [PMID:27875684]"}
{"concept_id": "C4691015", "aliases": [], "types": ["T043"], "canonical_name": "vacuole-mitochondria membrane tethering", "definition": "The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. [PMID:27875684]"}
{"concept_id": "C4691016", "aliases": ["neurite arborization", "neuron projection branching", "neurite branching"], "types": ["T043"], "canonical_name": "neuron projection arborization", "definition": "The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites. [GOC:aruk, GOC:bc, PMID:17114044, PMID:23270857, PMID:23764288]"}
{"concept_id": "C4691017", "aliases": [], "types": ["T043"], "canonical_name": "branching morphogenesis of a neurite"}
{"concept_id": "C4691018", "aliases": [], "types": ["T043"], "canonical_name": "branching morphogenesis of a neuron projection"}
{"concept_id": "C4691019", "aliases": [], "types": ["T043"], "canonical_name": "axon arborization", "definition": "The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches. [GOC:aruk, GOC:bc, PMID:23764288]"}
{"concept_id": "C4691020", "aliases": ["5hmC dioxygenase"], "types": ["T044"], "canonical_name": "5-hydroxymethylcytosine dioxygenase activity", "definition": "Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2. [PMID:27918559]"}
{"concept_id": "C4691021", "aliases": ["5fC dioxygenase"], "types": ["T044"], "canonical_name": "5-formylcytosine dioxygenase activity", "definition": "Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2. [PMID:27918559]"}
{"concept_id": "C4691022", "aliases": [], "types": ["T044"], "canonical_name": "peptide crotonyltransferase activity", "definition": "Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide. [PMID:25818647]"}
{"concept_id": "C4691023", "aliases": [], "types": ["T044"], "canonical_name": "protein crotonyltransferase activity"}
{"concept_id": "C4691024", "aliases": [], "types": ["T044"], "canonical_name": "peptide butyryltransferase activity", "definition": "Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide. [PMID:27105113]"}
{"concept_id": "C4691025", "aliases": [], "types": ["T044"], "canonical_name": "protein butyryltransferase activity"}
{"concept_id": "C4691026", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine crotonylation", "definition": "The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid. [PMID:25818647, Wikipedia:crotonyl]"}
{"concept_id": "C4691027", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine butyrylation", "definition": "The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid. [PMID:27105113, Wikipedia:butyryl]"}
{"concept_id": "C4691028", "aliases": [], "types": ["T044"], "canonical_name": "histone crotonyltransferase activity", "definition": "Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone. [PMID:25818647]"}
{"concept_id": "C4691029", "aliases": [], "types": ["T044"], "canonical_name": "histone butyryltransferase activity", "definition": "Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone. [PMID:27105113]"}
{"concept_id": "C4691030", "aliases": ["EndMT", "EndoMT"], "types": ["T043"], "canonical_name": "cardiac endothelial to mesenchymal transition", "definition": "A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes. [GOC:BHF, GOC:nc, PMID:16162442, PMID:26053665]"}
{"concept_id": "C4691031", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lipoprotein transport", "definition": "Any process that controls lipoprotein transport. [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192]"}
{"concept_id": "C4691032", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of lipoprotein transport", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport. [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192]"}
{"concept_id": "C4691033", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of lipoprotein transport", "definition": "Any process that activates or increases the rate or extent of lipoprotein transport. [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192]"}
{"concept_id": "C4691034", "aliases": [], "types": ["T045"], "canonical_name": "AP endonuclease class I activity"}
{"concept_id": "C4691035", "aliases": [], "types": ["T044"], "canonical_name": "class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity", "definition": "Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH. [PMID:2519777]"}
{"concept_id": "C4691036", "aliases": [], "types": ["T044"], "canonical_name": "glycosylated region protein binding", "definition": "Binding to a glycosylated region of a protein. [GOC:pg]"}
{"concept_id": "C4691037", "aliases": [], "types": ["T044"], "canonical_name": "SUMO-ubiquitin ligase activity", "definition": "Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. [PMID:28552615]"}
{"concept_id": "C4691038", "aliases": ["protein-DNA unloading ATPase activity"], "types": ["T044"], "canonical_name": "ATP-dependent protein-DNA unloading activity", "definition": "Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction. [PMID:28552615]"}
{"concept_id": "C4691039", "aliases": [], "types": ["T043"], "canonical_name": "sexual macrocyst formation", "definition": "The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum. [PMID:16592095, PMID:20089169]"}
{"concept_id": "C4691040", "aliases": [], "types": ["T040"], "canonical_name": "macrocyst formation"}
{"concept_id": "C4691041", "aliases": [], "types": ["T040"], "canonical_name": "sexual fusion"}
{"concept_id": "C4691042", "aliases": [], "types": ["T044"], "canonical_name": "membrane curvature sensor activity", "definition": "Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins. [PMID:25898166]"}
{"concept_id": "C4691043", "aliases": ["muscle-specific BAF complex", "muscle-type BAF complex", "muscle-type SWI/SNF complex", "muscle-specific BAF complex location", "muscle-type BAF complex location", "muscle-specific SWI/SNF complex location", "mBAF complex location", "muscle-type SWI/SNF complex location", "muscle-specific SWI/SNF complex"], "types": ["T026"], "canonical_name": "mBAF complex", "definition": "A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof. [GO:bhm, PMID:11175787, PMID:12620226, PMID:15525990, PMID:8804307, PMID:8895581]"}
{"concept_id": "C4691044", "aliases": ["brain-specific BAF complex", "brain-specific BAF complex location", "bBAF complex location", "brain-specific SWI/SNF complex location", "brain-specific SWI/SNF complex"], "types": ["T026"], "canonical_name": "bBAF complex", "definition": "A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180. [GOC:bhm, PMID:12368262, PMID:12620226, PMID:15525990, PMID:17640523, PMID:17920018, PMID:8804307, PMID:8895581]"}
{"concept_id": "C4691045", "aliases": ["embryonic stem cell-specific SWI/SNF complex", "embryonic stem cell-specific BAF complex", "embryonic stem cell-specific SWI/SNF complex location", "esBAF complex location", "embryonic stem cell-specific BAF complex location"], "types": ["T026"], "canonical_name": "esBAF complex", "definition": "An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C. [GOC:bhm, PMID:19279218, PMID:19279220, PMID:2620226, PMID:8804307, PMID:8895581]"}
{"concept_id": "C4691046", "aliases": [], "types": ["T044"], "canonical_name": "catalytic activity, acting on a protein", "definition": "Catalytic activity that acts to modify a protein. [GOC:molecular_function_refactoring, GOC:pdt]"}
{"concept_id": "C4691047", "aliases": [], "types": ["T044"], "canonical_name": "catalytic activity, acting on DNA", "definition": "Catalytic activity that acts to modify DNA. [GOC:molecular_function_refactoring, GOC:pdt]"}
{"concept_id": "C4691048", "aliases": [], "types": ["T044"], "canonical_name": "catalytic activity, acting on RNA", "definition": "Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. [GOC:molecular_function_refactoring, GOC:pdt]"}
{"concept_id": "C4691049", "aliases": [], "types": ["T044"], "canonical_name": "catalytic activity, acting on a tRNA", "definition": "Catalytic activity that acts to modify a tRNA. [GOC:molecular_function_refactoring, GOC:pdt]"}
{"concept_id": "C4691050", "aliases": [], "types": ["T044"], "canonical_name": "catalytic activity, acting on a rRNA", "definition": "Catalytic activity that acts to modify a ribosomal RNA. [GOC:molecular_function_refactoring, GOC:pdt]"}
{"concept_id": "C4691051", "aliases": [], "types": ["T044"], "canonical_name": "molecular carrier activity", "definition": "Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. [GOC:molecular_function_refactoring, GOC:pdt]"}
{"concept_id": "C4691052", "aliases": ["IL-10-mediated signaling pathway", "interleukin-10-mediated signalling pathway"], "types": ["T043"], "canonical_name": "interleukin-10-mediated signaling pathway", "definition": "The series of molecular signals initiated by interleukin-10 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [PMID:11244051]"}
{"concept_id": "C4691053", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity potassium ion transmembrane transporter activity", "definition": "Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [PMID:10629185]"}
{"concept_id": "C4691054", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity glucose transmembrane transporter activity", "definition": "Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [PMID:25411338]"}
{"concept_id": "C4691055", "aliases": [], "types": ["T044"], "canonical_name": "[choline trimethylamine-lyase]-activating enzyme activity", "definition": "Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM). [PMID:24854437]"}
{"concept_id": "C4691056", "aliases": ["extracellular vesicle assembly"], "types": ["T043"], "canonical_name": "extracellular vesicle biogenesis", "definition": "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. [PMID:28736435]"}
{"concept_id": "C4691057", "aliases": [], "types": ["T043"], "canonical_name": "extracellular microvesicle biogenesis", "definition": "The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding. [PMID:28736435]"}
{"concept_id": "C4691058", "aliases": [], "types": ["T043"], "canonical_name": "extracellular microvesicle assembly"}
{"concept_id": "C4691059", "aliases": [], "types": ["T043"], "canonical_name": "cellular detoxification of fluoride", "definition": "Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:vw]"}
{"concept_id": "C4691060", "aliases": ["export from cell", "efflux"], "types": ["T043"], "canonical_name": "export across plasma membrane", "definition": "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:pg]"}
{"concept_id": "C4691061", "aliases": [], "types": ["T043"], "canonical_name": "fluoride export across plasma membrane", "definition": "The directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:27327046]"}
{"concept_id": "C4691062", "aliases": [], "types": ["T043"], "canonical_name": "Lewy body formation", "definition": "The aggregation, arrangement and bonding together of a set of components to form a Lewy body. [PMID:15158159]"}
{"concept_id": "C4691063", "aliases": [], "types": ["T043"], "canonical_name": "regulation of Lewy body formation", "definition": "Any process that modulates the frequency, rate or extent of Lewy body formation. [GOC:sl]"}
{"concept_id": "C4691064", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of Lewy body formation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of Lewy body formation. [GOC:sl]"}
{"concept_id": "C4691065", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of Lewy body formation", "definition": "Any process that activates or increases the frequency, rate or extent of Lewy body formation. [GOC:sl]"}
{"concept_id": "C4691066", "aliases": [], "types": ["T043"], "canonical_name": "thiamine import across plasma membrane", "definition": "The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:vw]"}
{"concept_id": "C4691067", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of lymphocyte chemotaxis", "definition": "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis. [PMID:19255442]"}
{"concept_id": "C4691068", "aliases": [], "types": ["T044"], "canonical_name": "iron-sulfur cluster carrier activity", "definition": "Binding to an iron-sulfur cluster and delivering it to an acceptor molecule. [PMID:22966982, PMID:29051382]"}
{"concept_id": "C4691069", "aliases": [], "types": ["T040"], "canonical_name": "suppression by symbiont of host cytokine secretion"}
{"concept_id": "C4691070", "aliases": ["mechanically-gated cation channel activity"], "types": ["T044"], "canonical_name": "mechanosensitive cation channel activity", "definition": "Enables the transmembrane transfer of a cation by a channel that opens in response to a mechanical stress. [GOC:ha, PMID:22343900]"}
{"concept_id": "C4691071", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial guanine nucleotide transmembrane transport", "definition": "The process in which a guanine nucleotide is transported across a mitochondrial membrane, into or out of the mitochondrion. [GOC:vw, PMID:14998997]"}
{"concept_id": "C4691072", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial potassium ion transmembrane transport", "definition": "The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion. [GOC:vw, PMID:20197279]"}
{"concept_id": "C4691073", "aliases": ["nucleocytoplasmic importin/exportin activity"], "types": ["T044"], "canonical_name": "nucleocytoplasmic carrier activity", "definition": "Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein. [GOC:pg]"}
{"concept_id": "C4691074", "aliases": [], "types": ["T044"], "canonical_name": "miRNA transporter activity"}
{"concept_id": "C4691075", "aliases": [], "types": ["T044"], "canonical_name": "pre-miRNA transporter activity"}
{"concept_id": "C4691076", "aliases": [], "types": ["T043"], "canonical_name": "copper ion export from vacuole", "definition": "The directed movement of copper ions out of the vacuole across the vacuolar membrane. [GOC:vw, PMID:12244050]"}
{"concept_id": "C4691077", "aliases": [], "types": ["T043"], "canonical_name": "calcium ion import into vacuole", "definition": "The directed movement of calcium cations into the vacuole across the vacuolar membrane. [GOC:vw, PMID:8628289]"}
{"concept_id": "C4691078", "aliases": [], "types": ["T043"], "canonical_name": "zinc ion export from vacuole", "definition": "The directed movement of zinc ions from inside the vacuole across the vacuolar membrane and into the cytosol. [GOC:vw, PMC:PMC203372]"}
{"concept_id": "C4691079", "aliases": [], "types": ["T043"], "canonical_name": "ammonium import across plasma membrane", "definition": "The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol. [GOC:vw, PMID:16999738]"}
{"concept_id": "C4691080", "aliases": [], "types": ["T044"], "canonical_name": "borate export across plasma membrane", "definition": "The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:17459946]"}
{"concept_id": "C4691081", "aliases": [], "types": ["T044"], "canonical_name": "monocarboxylate:sodium symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in). [GOC:ln, PMID:15322102]"}
{"concept_id": "C4691082", "aliases": ["COG complex binding"], "types": ["T044"], "canonical_name": "Golgi transport complex binding", "definition": "Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family. [GOC:ha, PMID:28100664]"}
{"concept_id": "C4691083", "aliases": [], "types": ["T038"], "canonical_name": "regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process", "definition": "Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4691084", "aliases": [], "types": ["T038"], "canonical_name": "regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process", "definition": "Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4691085", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4691086", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process", "definition": "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4691087", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process", "definition": "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4691088", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]"}
{"concept_id": "C4691089", "aliases": [], "types": ["T038"], "canonical_name": "adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate", "definition": "An adrenergic receptor signaling pathway that modulates the frequency or rate of heart contraction. [GOC:BHF]"}
{"concept_id": "C4691090", "aliases": [], "types": ["T043"], "canonical_name": "urea import across plasma membrane", "definition": "The directed movement of urea from outside of a cell, across the plasma membrane and into the cytosol. [PMID:17218313]"}
{"concept_id": "C4691091", "aliases": [], "types": ["T043"], "canonical_name": "polyamine import across plasma membrane", "definition": "The directed movement of a polyamine from outside of a cell, across the plasma membrane and into the cytosol. [PMID:17218313]"}
{"concept_id": "C4691092", "aliases": [], "types": ["T043"], "canonical_name": "spermidine import across plasma membrane", "definition": "The directed movement of spermidine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:vw]"}
{"concept_id": "C4691093", "aliases": [], "types": ["T043"], "canonical_name": "pyridoxal import across plasma membrane", "definition": "The directed movement of pyridoxal from outside of a cell, across the plasma membrane and into the cytosol. [GOC:vw]"}
{"concept_id": "C4691094", "aliases": [], "types": ["T043"], "canonical_name": "oligopeptide import across plasma membrane", "definition": "The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol. [PMID:22226946]"}
{"concept_id": "C4691095", "aliases": [], "types": ["T043"], "canonical_name": "dipeptide import across plasma membrane", "definition": "The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol. [PMID:22226946]"}
{"concept_id": "C4691096", "aliases": [], "types": ["T043"], "canonical_name": "tripeptide import across plasma membrane", "definition": "The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol. [PMID:22226946]"}
{"concept_id": "C4691097", "aliases": ["apoptosis in response to mitochondrial fragmentation"], "types": ["T043"], "canonical_name": "apoptotic process in response to mitochondrial fragmentation", "definition": "Any apoptotic process that occurs as a result of mitochondrial fragmentation. [PMID:18940801]"}
{"concept_id": "C4691098", "aliases": ["zinc(2+) import into endoplasmic reticulum", "zinc(2+) import across endoplasmic reticulum", "zinc ion import into ER", "zinc ion import across endoplasmic reticulum"], "types": ["T044"], "canonical_name": "zinc ion import into endoplasmic reticulum", "definition": "The directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum. [PMID:11886869, PMID:29529046]"}
{"concept_id": "C4691099", "aliases": [], "types": ["T043"], "canonical_name": "protein transport along microtubule to kinetochore", "definition": "Any process in which a protein is transported to the kinetochore along a microtubule. [PMID:25472718]"}
{"concept_id": "C4691100", "aliases": [], "types": ["T044"], "canonical_name": "folic acid:proton symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid. [PMID:24745983]"}
{"concept_id": "C4691101", "aliases": [], "types": ["T044"], "canonical_name": "regulation of long-chain fatty acid import into cell", "definition": "Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell. [PMID:28178239]"}
{"concept_id": "C4691102", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of long-chain fatty acid import into cell", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of long-chain fatty acid import into a cell. [PMID:28178239]"}
{"concept_id": "C4691103", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of long-chain fatty acid import into cell", "definition": "Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell. [PMID:28178239]"}
{"concept_id": "C4691104", "aliases": [], "types": ["T044"], "canonical_name": "regulation of D-aspartate import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. [PMID:27663541]"}
{"concept_id": "C4691105", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of D-aspartate import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. [PMID:27663541]"}
{"concept_id": "C4691106", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of D-aspartate import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. [PMID:27663541]"}
{"concept_id": "C4691107", "aliases": [], "types": ["T026"], "canonical_name": "pathogen-containing vacuole", "definition": "A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides. [PMID:10560000, PMID:26842840]"}
{"concept_id": "C4691108", "aliases": [], "types": ["T026"], "canonical_name": "pathogen inclusion"}
{"concept_id": "C4691109", "aliases": [], "types": ["T026"], "canonical_name": "pathogen-containing compartment"}
{"concept_id": "C4691110", "aliases": ["pathogen-containing compartment membrane"], "types": ["T026"], "canonical_name": "pathogen-containing vacuole membrane", "definition": "Host-derived membrane of a pathogen-containing vacuole. [PMID:10560000, PMID:26842840]"}
{"concept_id": "C4691111", "aliases": [], "types": ["T026"], "canonical_name": "pathogen inclusion membrane"}
{"concept_id": "C4691112", "aliases": ["pathogen-containing compartment lumen", "lumen of a pathogen-containing vacuole", "pathogen-containing vacuolar lumen"], "types": ["T026"], "canonical_name": "pathogen-containing vacuole lumen", "definition": "The enclosed volume within the sealed membrane of a pathogen-containing vacuole. [PMID:10560000, PMID:26842840]"}
{"concept_id": "C4691113", "aliases": [], "types": ["T026"], "canonical_name": "pathogen inclusion lumen"}
{"concept_id": "C4691114", "aliases": [], "types": ["T026"], "canonical_name": "primary dendrite", "definition": "A dendrite emerging from the cell body (the soma) of a neuron. [GOC:aruk, GOC:bc]"}
{"concept_id": "C4691115", "aliases": [], "types": ["T026"], "canonical_name": "distal dendrite", "definition": "The dendrite of the dendritic tree that is farthest away from the neuronal cell body (the soma). [GOC:aruk, GOC:bc, PMID:20629984]"}
{"concept_id": "C4691116", "aliases": [], "types": ["T043"], "canonical_name": "regulation of spontaneous synaptic transmission", "definition": "Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission. [GOC:aruk, GOC:bc, PMID:15457210]"}
{"concept_id": "C4691117", "aliases": [], "types": ["T026"], "canonical_name": "dendritic spine origin", "definition": "The part of the dendritic spine neck where the spine arises from the dendritic shaft. [GOC:aruk, GOC:bc, PMID:9030614]"}
{"concept_id": "C4691118", "aliases": ["enzyme activator complex location"], "types": ["T026"], "canonical_name": "enzyme activator complex", "definition": "A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active. [GOC:bhm, PMID:16244137, PMID:28710280]"}
{"concept_id": "C4691119", "aliases": ["urease activator complex location"], "types": ["T026"], "canonical_name": "urease activator complex", "definition": "A protein complex required for the activation of urease. Activator subunits dissociate before urease has catalytic function. [GOC:bhm, PMID:16244137, PMID:28710280]"}
{"concept_id": "C4691120", "aliases": [], "types": ["T043"], "canonical_name": "clathrin-dependent synaptic vesicle endocytosis", "definition": "Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds. [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786]"}
{"concept_id": "C4691121", "aliases": ["bulk endocytosis", "ADBE", "activity-dependent bulk endocytosis", "activity-dependent bulk synaptic vesicle endocytosis"], "types": ["T043"], "canonical_name": "bulk synaptic vesicle endocytosis", "definition": "Endocytosis of large regions of presynaptic membrane after intense stimulation-mediated fusion of multiple synaptic vesicles. Bulk endocytosis is triggered by high loads of membrane addition through exocytosis of synaptic vesicles and elevated concentration of calcium in the presynapse. [GOC:aruk, GOC:bc, GOC:ha, PMID:18250322, PMID:18579735, PMID:19266323, PMID:26430111, PMID:28391090]"}
{"concept_id": "C4691122", "aliases": ["regulation of neurite arborization", "regulation of neuron projection branching", "regulation of neurite branching"], "types": ["T043"], "canonical_name": "regulation of neuron projection arborization", "definition": "Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. [GOC:aruk, GOC:bc, PMID:17114044]"}
{"concept_id": "C4691123", "aliases": ["positive regulation of neuron projection branching", "positive regulation of neurite arborization", "positive regulation of neurite branching"], "types": ["T043"], "canonical_name": "positive regulation of neuron projection arborization", "definition": "Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. [GOC:aruk, GOC:bc, PMID:17114044]"}
{"concept_id": "C4691124", "aliases": ["negative regulation of neuron projection branching", "negative regulation of neurite arborization", "negative regulation of neurite branching"], "types": ["T043"], "canonical_name": "negative regulation of neuron projection arborization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. [GOC:aruk, GOC:bc, PMID:17114044]"}
{"concept_id": "C4691125", "aliases": [], "types": ["T026"], "canonical_name": "apical distal dendrite", "definition": "Any dendrite in a dendritic tree that emerges near the apical pole of a neuron, and which is farthest away from the neuronal cell body (the soma). [GO:bc, GOC:aruk, PMID:1720142, PMID:20629984, PMID:9214543]"}
{"concept_id": "C4691126", "aliases": [], "types": ["T026"], "canonical_name": "apical proximal dendrite", "definition": "The dendrite of the dendritic tree, which emerges near the apical pole of a neuron, and which is the closest to the cell body of the neuron (the soma). [GOC:aruk, GOC:bc, PMID:16899232, PMID:1720142, PMID:9214543]"}
{"concept_id": "C4691127", "aliases": [], "types": ["T026"], "canonical_name": "basal distal dendrite", "definition": "Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is farthest away from the neuronal cell body (the soma). [GOC:aruk, GOC:bc, PMID:17046728, PMID:1720142, PMID:20629984, PMID:22683681, PMID:9214543]"}
{"concept_id": "C4691128", "aliases": [], "types": ["T026"], "canonical_name": "basal proximal dendrite", "definition": "Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is the closest to the cell body of the neuron (the soma). [GOC:aruk, GOC:bc, PMID:16899232, PMID:17046728, PMID:1720142, PMID:22683681, PMID:9214543]"}
{"concept_id": "C4691129", "aliases": [], "types": ["T043"], "canonical_name": "basal dendrite development", "definition": "The process whose specific outcome is the progression of a basal dendrite over time, from its formation to the mature structure. [GOC:aruk, GOC:bc, PMID:22683681]"}
{"concept_id": "C4691130", "aliases": [], "types": ["T043"], "canonical_name": "basal dendrite morphogenesis", "definition": "The process in which the anatomical structures of a basal dendrite are generated and organized. [GOC:aruk, GOC:bc, PMID:22683681]"}
{"concept_id": "C4691131", "aliases": [], "types": ["T043"], "canonical_name": "basal dendrite arborization", "definition": "The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches. [GOC:aruk, GOC:bc, PMID:22683681]"}
{"concept_id": "C4691132", "aliases": [], "types": ["T043"], "canonical_name": "apical dendrite morphogenesis", "definition": "The process in which the anatomical structures of an apical dendrite are generated and organized. [GOC:aruk, GOC:bc, PMID:22683681]"}
{"concept_id": "C4691133", "aliases": [], "types": ["T040"], "canonical_name": "apical dendrite development", "definition": "The process whose specific outcome is the progression of an apical dendrite over time, from its formation to the mature structure. [GOC:aruk, GOC:bc, PMID:22683681]"}
{"concept_id": "C4691134", "aliases": [], "types": ["T043"], "canonical_name": "apical dendrite arborization", "definition": "The process in which the anatomical structures of a dendritic tree are generated on the apical neuron side and organized into dendritic branches. [GOC:aruk, GOC:bc, PMID:22683681]"}
{"concept_id": "C4691135", "aliases": ["oxLDL particle clearance", "oxidized LDL particle clearance", "ox-LDL particle clearance", "oxidized low-density lipoprotein particle clearance", "oxidised LDL particle clearance"], "types": ["T043"], "canonical_name": "oxidised low-density lipoprotein particle clearance", "definition": "The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:aruk, GOC:bc, PMID:27607416]"}
{"concept_id": "C4691136", "aliases": ["oxLDL particle receptor activity", "oxidized LDL particle receptor activity", "oxidized low-density lipoprotein particle receptor activity", "ox-LDL particle receptor activity", "oxidised LDL particle receptor activity"], "types": ["T044"], "canonical_name": "oxidised low-density lipoprotein particle receptor activity", "definition": "Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis. [GOC:aruk, GOC:bc, PMID:27607416]"}
{"concept_id": "C4691137", "aliases": [], "types": ["T044"], "canonical_name": "ox-LDL receptor activity"}
{"concept_id": "C4691138", "aliases": ["oxidized LDL receptor activity"], "types": ["T044"], "canonical_name": "oxidised LDL receptor activity"}
{"concept_id": "C4691139", "aliases": ["oxidized low-density lipoprotein receptor activity"], "types": ["T044"], "canonical_name": "oxidised low-density lipoprotein receptor activity"}
{"concept_id": "C4691140", "aliases": [], "types": ["T044"], "canonical_name": "oxLDL receptor activity"}
{"concept_id": "C4691141", "aliases": [], "types": ["T039"], "canonical_name": "regulation of protein localization to lysosome", "definition": "Any process that modulates the frequency, rate or extent of protein localization to lysosome. [GOC:aruk, GOC:bc, PMID:24305806]"}
{"concept_id": "C4691142", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of protein localization to lysosome", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome. [GOC:aruk, GOC:bc]"}
{"concept_id": "C4691143", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of protein localization to lysosome", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome. [GOC:aruk, GOC:bc, PMID:24305806]"}
{"concept_id": "C4691144", "aliases": ["distal part of axon", "distal part of the axon"], "types": ["T026"], "canonical_name": "distal axon", "definition": "That part of an axon close to and including the growth cone or the axon terminus. [GOC:aruk, GOC:bc, PMID:17202468]"}
{"concept_id": "C4691145", "aliases": [], "types": ["T039"], "canonical_name": "regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission", "definition": "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission. [GOC:aruk, GOC:bc, PMID:19448629]"}
{"concept_id": "C4691146", "aliases": [], "types": ["T038"], "canonical_name": "regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission", "definition": "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. [GOC:aruk, GOC:bc, PMID:27296803]"}
{"concept_id": "C4691147", "aliases": [], "types": ["T043"], "canonical_name": "regulation of calcium-dependent activation of synaptic vesicle fusion", "definition": "Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion. [GOC:aruk, GOC:bc, PMID:27052163]"}
{"concept_id": "C4691148", "aliases": [], "types": ["T043"], "canonical_name": "postsynaptic dense core vesicle exocytosis", "definition": "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels. [GOC:aruk, GOC:bc, PMID:19448629]"}
{"concept_id": "C4691149", "aliases": ["synapse-associated extracellular matrix structural constituent", "extra-synaptic extracellular matrix structural constituent", "structural constituent of extra-synaptic extracellular matrix"], "types": ["T044"], "canonical_name": "structural constituent of synapse-associated extracellular matrix", "definition": "The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. [GOC:aruk, GOC:bc, PMID:17189701]"}
{"concept_id": "C4691150", "aliases": [], "types": ["T043"], "canonical_name": "regulation of postsynaptic dense core vesicle exocytosis", "definition": "Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis. [GOC:aruk, GOC:bc, PMID:19448629]"}
{"concept_id": "C4691151", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic signaling by nitric oxide", "definition": "Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide. [GOC:aruk, GOC:bc, PMID:26311509]"}
{"concept_id": "C4691152", "aliases": ["G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential"], "types": ["T044"], "canonical_name": "G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "definition": "G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. [GOC:aruk, GOC:bc, PMID:11498050]"}
{"concept_id": "C4691153", "aliases": ["cerebellar parallel fiber to Purkinje cell synapse"], "types": ["T026"], "canonical_name": "cerebellar granule cell to Purkinje cell synapse", "definition": "A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum. [GOC:aruk, GOC:bc, PMID:12427822]"}
{"concept_id": "C4691154", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic septin cytoskeleton", "definition": "The portion of the septin cytoskeleton contained within the postsynapse. [GOC:aruk, GOC:bc, PMID:28065648]"}
{"concept_id": "C4691155", "aliases": [], "types": ["T026"], "canonical_name": "postsynaptic Golgi apparatus", "definition": "The network of the Golgi apparatus structures located within the postsynapse. [GOC:aruk, GOC:bc, PMID:23838184]"}
{"concept_id": "C4691156", "aliases": [], "types": ["T026"], "canonical_name": "Golgi outpost"}
{"concept_id": "C4691157", "aliases": [], "types": ["T038"], "canonical_name": "regulation of postsynapse assembly", "definition": "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854]"}
{"concept_id": "C4691158", "aliases": ["cerebellar climbing fibre to Purkinje cell synapse"], "types": ["T026"], "canonical_name": "cerebellar climbing fiber to Purkinje cell synapse", "definition": "A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata. [GOC:aruk, GOC:bc, PMID:19597563, PMID:23811844, PMID:5044254]"}
{"concept_id": "C4691159", "aliases": [], "types": ["T038"], "canonical_name": "regulation of postsynaptic neurotransmitter receptor diffusion trapping", "definition": "Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping. [GOC:aruk, GOC:bc, PMID:20935643]"}
{"concept_id": "C4691160", "aliases": [], "types": ["T044"], "canonical_name": "regulation of glycine import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of glycine import into a cell. [GOC:TermGenie]"}
{"concept_id": "C4691161", "aliases": [], "types": ["T044"], "canonical_name": "NF-kappaB import into nucleus"}
{"concept_id": "C4691162", "aliases": [], "types": ["T044"], "canonical_name": "NF-KB import into nucleus"}
{"concept_id": "C4691163", "aliases": [], "types": ["T044"], "canonical_name": "regulation of NF-kappaB import into nucleus"}
{"concept_id": "C4691164", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of NF-kappaB import into nucleus"}
{"concept_id": "C4691165", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cytoplasmic NF-kappaB storage"}
{"concept_id": "C4691166", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of NF-kappaB import into nucleus"}
{"concept_id": "C4691167", "aliases": [], "types": ["T044"], "canonical_name": "release of cytoplasmic sequestered NF-kappaB"}
{"concept_id": "C4691168", "aliases": [], "types": ["T044"], "canonical_name": "release of NF-kappaB sequestered in cytoplasm"}
{"concept_id": "C4691169", "aliases": [], "types": ["T044"], "canonical_name": "malonic acid uptake transmembrane transporter activity"}
{"concept_id": "C4691170", "aliases": [], "types": ["T044"], "canonical_name": "azole transporter activity"}
{"concept_id": "C4691171", "aliases": [], "types": ["T044"], "canonical_name": "aminotriazole transporter activity"}
{"concept_id": "C4691172", "aliases": [], "types": ["T044"], "canonical_name": "benomyl transporter activity"}
{"concept_id": "C4691173", "aliases": [], "types": ["T044"], "canonical_name": "oleate transmembrane transporter activity", "definition": "Enables the transfer of oleate from one side of a membrane to the other. [GOC:TermGenie, PMID:19493158, RHEA:33655]"}
{"concept_id": "C4691174", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate derivative transmembrane transporter activity", "definition": "Enables the transfer of carbohydrate derivative from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]"}
{"concept_id": "C4691177", "aliases": [], "types": ["T043"], "canonical_name": "polyamine import"}
{"concept_id": "C4691178", "aliases": [], "types": ["T043"], "canonical_name": "polyamine uptake"}
{"concept_id": "C4691179", "aliases": [], "types": ["T043"], "canonical_name": "hydrogen ion transport"}
{"concept_id": "C4691180", "aliases": ["establishment of protein localization to prospore membrane", "establishment of protein localization in prospore membrane", "establishment of protein localisation to prospore membrane"], "types": ["T043"], "canonical_name": "establishment of protein localisation in prospore membrane"}
{"concept_id": "C4691181", "aliases": [], "types": ["T043"], "canonical_name": "protein targeting to ascospore-type prospore membrane"}
{"concept_id": "C4691182", "aliases": [], "types": ["T043"], "canonical_name": "protein targeting to forespore membrane"}
{"concept_id": "C4691183", "aliases": [], "types": ["T043"], "canonical_name": "protein targeting to FSM"}
{"concept_id": "C4691184", "aliases": ["protein-prospore membrane targeting"], "types": ["T043"], "canonical_name": "protein targeting to prospore membrane"}
{"concept_id": "C4691185", "aliases": ["regulation of establishment of protein localisation in plasma membrane", "regulation of establishment of protein localization to plasma membrane"], "types": ["T043"], "canonical_name": "regulation of establishment of protein localization in plasma membrane"}
{"concept_id": "C4691186", "aliases": ["regulation of protein-plasma membrane targeting"], "types": ["T043"], "canonical_name": "regulation of protein targeting to plasma membrane"}
{"concept_id": "C4691187", "aliases": ["downregulation of protein targeting to plasma membrane", "down-regulation of protein-plasma membrane targeting", "down regulation of protein-plasma membrane targeting", "downregulation of protein-plasma membrane targeting", "down-regulation of protein targeting to plasma membrane"], "types": ["T043"], "canonical_name": "down regulation of protein targeting to plasma membrane"}
{"concept_id": "C4691188", "aliases": ["inhibition of protein-plasma membrane targeting"], "types": ["T043"], "canonical_name": "inhibition of protein targeting to plasma membrane"}
{"concept_id": "C4691189", "aliases": ["negative regulation of establishment of protein localization to plasma membrane", "negative regulation of establishment of protein localisation in plasma membrane"], "types": ["T043"], "canonical_name": "negative regulation of establishment of protein localization in plasma membrane"}
{"concept_id": "C4691190", "aliases": ["negative regulation of protein-plasma membrane targeting"], "types": ["T043"], "canonical_name": "negative regulation of protein targeting to plasma membrane"}
{"concept_id": "C4691191", "aliases": ["activation of protein-plasma membrane targeting"], "types": ["T043"], "canonical_name": "activation of protein targeting to plasma membrane"}
{"concept_id": "C4691192", "aliases": ["positive regulation of establishment of protein localization to plasma membrane"], "types": ["T043"], "canonical_name": "positive regulation of establishment of protein localisation in plasma membrane"}
{"concept_id": "C4691193", "aliases": ["positive regulation of protein-plasma membrane targeting"], "types": ["T043"], "canonical_name": "positive regulation of protein targeting to plasma membrane"}
{"concept_id": "C4691194", "aliases": ["up-regulation of protein-plasma membrane targeting", "upregulation of protein-plasma membrane targeting", "upregulation of protein targeting to plasma membrane", "up regulation of protein-plasma membrane targeting", "up-regulation of protein targeting to plasma membrane"], "types": ["T043"], "canonical_name": "up regulation of protein targeting to plasma membrane"}
{"concept_id": "C4691195", "aliases": [], "types": ["T043"], "canonical_name": "regulation of autophagy of mitochondrion", "definition": "Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process. [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]"}
{"concept_id": "C4691196", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of autophagy of mitochondrion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation by autophagy. [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]"}
{"concept_id": "C4691198", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sodium export"}
{"concept_id": "C4691199", "aliases": [], "types": ["T043"], "canonical_name": "regulation of sodium ion export"}
{"concept_id": "C4691200", "aliases": ["down-regulation of sodium export", "downregulation of sodium export"], "types": ["T043"], "canonical_name": "down regulation of sodium export"}
{"concept_id": "C4691201", "aliases": ["down-regulation of sodium ion export", "downregulation of sodium ion export"], "types": ["T043"], "canonical_name": "down regulation of sodium ion export"}
{"concept_id": "C4691202", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sodium export"}
{"concept_id": "C4691203", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of sodium ion export"}
{"concept_id": "C4691204", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of sodium export"}
{"concept_id": "C4691205", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of sodium ion export"}
{"concept_id": "C4691206", "aliases": [], "types": ["T043"], "canonical_name": "activation of sodium export"}
{"concept_id": "C4691207", "aliases": [], "types": ["T043"], "canonical_name": "activation of sodium ion export"}
{"concept_id": "C4691208", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of sodium export"}
{"concept_id": "C4691209", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of sodium ion export"}
{"concept_id": "C4691210", "aliases": ["upregulation of sodium export", "up-regulation of sodium export"], "types": ["T043"], "canonical_name": "up regulation of sodium export"}
{"concept_id": "C4691211", "aliases": ["up-regulation of sodium ion export", "upregulation of sodium ion export"], "types": ["T043"], "canonical_name": "up regulation of sodium ion export"}
{"concept_id": "C4691212", "aliases": [], "types": ["T045"], "canonical_name": "regulation of transcription initiation from RNA polymerase I promoter", "definition": "Any process that modulates the frequency, rate or extent of transcription initiation from RNA polymerase I promoter. [GO_REF:0000058, GOC:TermGenie, PMID:9092673]"}
{"concept_id": "C4691213", "aliases": [], "types": ["T043"], "canonical_name": "release of sequestered calcium ion into cytosol by endoplasmic reticulum", "definition": "The directed movement of calcium ion from endoplasmic reticulum to cytosol. [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]"}
{"concept_id": "C4691214", "aliases": [], "types": ["T043"], "canonical_name": "methionine import"}
{"concept_id": "C4691215", "aliases": [], "types": ["T043"], "canonical_name": "L-leucine import"}
{"concept_id": "C4691216", "aliases": [], "types": ["T043"], "canonical_name": "L-leucine uptake"}
{"concept_id": "C4691217", "aliases": [], "types": ["T043"], "canonical_name": "leucine import"}
{"concept_id": "C4691218", "aliases": [], "types": ["T043"], "canonical_name": "L-glutamine import"}
{"concept_id": "C4691219", "aliases": [], "types": ["T043"], "canonical_name": "glycine import"}
{"concept_id": "C4691220", "aliases": [], "types": ["T043"], "canonical_name": "valine import"}
{"concept_id": "C4691221", "aliases": [], "types": ["T043"], "canonical_name": "isoleucine import"}
{"concept_id": "C4691222", "aliases": [], "types": ["T043"], "canonical_name": "L-isoleucine import"}
{"concept_id": "C4691223", "aliases": [], "types": ["T043"], "canonical_name": "L-threonine import"}
{"concept_id": "C4691224", "aliases": [], "types": ["T043"], "canonical_name": "L-tyrosine import"}
{"concept_id": "C4691225", "aliases": [], "types": ["T043"], "canonical_name": "histidine import"}
{"concept_id": "C4691226", "aliases": [], "types": ["T043"], "canonical_name": "L-histidine import"}
{"concept_id": "C4691227", "aliases": [], "types": ["T043"], "canonical_name": "asparagine import"}
{"concept_id": "C4691228", "aliases": [], "types": ["T044"], "canonical_name": "arachidonate transmembrane transporter activity", "definition": "Enables the transfer of arachidonate from one side of a membrane to the other. [GO_REF:0000066, GOC:bhm, GOC:TermGenie, PMID:15642721]"}
{"concept_id": "C4691229", "aliases": [], "types": ["T044"], "canonical_name": "peptide transporter activity"}
{"concept_id": "C4691230", "aliases": [], "types": ["T044"], "canonical_name": "peptide uptake permease activity"}
{"concept_id": "C4691231", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of electron transfer activity", "definition": "Any process that activates or increases the frequency, rate or extent of electron transfer activity. [GO_REF:0000059, GOC:TermGenie, PMID:25416781]"}
{"concept_id": "C4691232", "aliases": [], "types": ["T044"], "canonical_name": "folate import into mitochondrion", "definition": "The process in which folic acid is transported from the cytosol into the mitochondrial matrix. [GO_REF:0000075, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:15140890]"}
{"concept_id": "C4691233", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lysine import"}
{"concept_id": "C4691234", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lysine import"}
{"concept_id": "C4691235", "aliases": [], "types": ["T043"], "canonical_name": "vacuolar phosphate transport"}
{"concept_id": "C4691236", "aliases": [], "types": ["T043"], "canonical_name": "biotin import"}
{"concept_id": "C4691237", "aliases": [], "types": ["T043"], "canonical_name": "dethiobiotin import"}
{"concept_id": "C4691238", "aliases": [], "types": ["T043"], "canonical_name": "activation of L-arginine import"}
{"concept_id": "C4691239", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of L-arginine import"}
{"concept_id": "C4691240", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cartilage homeostasis"}
{"concept_id": "C4691241", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cartilage homeostasis"}
{"concept_id": "C4691242", "aliases": [], "types": ["T043"], "canonical_name": "nucleolus to nucleoplasm transport"}
{"concept_id": "C4691243", "aliases": [], "types": ["T044"], "canonical_name": "scaffoldin complex binding"}
{"concept_id": "C4691244", "aliases": ["WHY1 complex location"], "types": ["T026"], "canonical_name": "WHY1 complex"}
{"concept_id": "C4691245", "aliases": ["aminophospholipid translocase complex", "phospholipid flippase complex", "phospholipid flippase complex location", "aminophospholipid translocase complex location", "phospholipid-translocating ATPase complex location", "APLT complex", "P4-ATPase complex location", "APLT complex location", "P4-ATPase complex"], "types": ["T026"], "canonical_name": "phospholipid-translocating ATPase complex", "definition": "A protein complex that functions as a phospholipid-translocating P-Type ATPase. [GOC:dph, GOC:rb, PMID:15090616]"}
{"concept_id": "C4691246", "aliases": ["CDC50-DRS2 complex location"], "types": ["T026"], "canonical_name": "CDC50-DRS2 complex"}
{"concept_id": "C4691247", "aliases": ["CRF1-DNF3 complex location"], "types": ["T026"], "canonical_name": "CRF1-DNF3 complex"}
{"concept_id": "C4691248", "aliases": ["Dnf1-Lem3 complex location"], "types": ["T026"], "canonical_name": "Dnf1-Lem3 complex"}
{"concept_id": "C4691249", "aliases": ["Dnf2-Lem3 complex location"], "types": ["T026"], "canonical_name": "Dnf2-Lem3 complex"}
{"concept_id": "C4691250", "aliases": ["DNF3-CRF1 complex location"], "types": ["T026"], "canonical_name": "DNF3-CRF1 complex"}
{"concept_id": "C4691251", "aliases": ["DRS2-CDC50 complex location"], "types": ["T026"], "canonical_name": "DRS2-CDC50 complex"}
{"concept_id": "C4691252", "aliases": ["Lem3-Dnf1 complex location"], "types": ["T026"], "canonical_name": "Lem3-Dnf1 complex"}
{"concept_id": "C4691253", "aliases": [], "types": ["T043"], "canonical_name": "axon homeostasis"}
{"concept_id": "C4691254", "aliases": [], "types": ["T043"], "canonical_name": "axon maintenance"}
{"concept_id": "C4691255", "aliases": [], "types": ["T043"], "canonical_name": "UDP-N-acetylglucosamine transport"}
{"concept_id": "C4691256", "aliases": [], "types": ["T043"], "canonical_name": "GDP-mannose transport"}
{"concept_id": "C4691257", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial ornithine transport"}
{"concept_id": "C4691258", "aliases": ["extracellular ribonucleoprotein complex location"], "types": ["T026"], "canonical_name": "extracellular ribonucleoprotein complex"}
{"concept_id": "C4691259", "aliases": ["intracellular ribonucleoprotein complex location"], "types": ["T026"], "canonical_name": "intracellular ribonucleoprotein complex"}
{"concept_id": "C4691260", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of ubiquitin-dependent protein catabolic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process. [GOC:BHF]"}
{"concept_id": "C4691261", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of ubiquitin-dependent protein catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process. [GOC:BHF]"}
{"concept_id": "C4691262", "aliases": ["negative regulation of signalling receptor activity"], "types": ["T044"], "canonical_name": "negative regulation of signaling receptor activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity. [GOC:obol]"}
{"concept_id": "C4691263", "aliases": ["regulation of protein localisation to prospore membrane"], "types": ["T043"], "canonical_name": "regulation of protein localization to prospore membrane", "definition": "Any process that modulates the frequency, rate or extent of protein localization to prospore membrane. [GOC:mah]"}
{"concept_id": "C4691264", "aliases": ["positive regulation of protein localisation to prospore membrane"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to prospore membrane", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to prospore membrane. [GOC:mah]"}
{"concept_id": "C4691265", "aliases": [], "types": ["T044"], "canonical_name": "phytochelatin transmembrane transporter activity"}
{"concept_id": "C4691266", "aliases": [], "types": ["T044"], "canonical_name": "solanine UDP-galactose galactosyltransferase activity", "definition": "Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP. [EC:2.4.1.-, GOC:pz]"}
{"concept_id": "C4691267", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitin protein ligase activity involved in ER-associated degradation pathway"}
{"concept_id": "C4691268", "aliases": [], "types": ["T026"], "canonical_name": "TOC-TIC supercomplex I", "definition": "The protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110. [PMID:28745032]"}
{"concept_id": "C4691269", "aliases": [], "types": ["T044"], "canonical_name": "catalytic activity, acting on a glycoprotein", "definition": "Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. [GOC:molecular_function_refactoring, GOC:pdt]"}
{"concept_id": "C4691270", "aliases": [], "types": ["T043"], "canonical_name": "fucose transmembrane transport", "definition": "The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. [GOC:ai]"}
{"concept_id": "C4691271", "aliases": [], "types": ["T043"], "canonical_name": "GDP-fucose transmembrane transport", "definition": "The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. [GOC:ai]"}
{"concept_id": "C4691272", "aliases": [], "types": ["T044"], "canonical_name": "lysine import"}
{"concept_id": "C4691273", "aliases": [], "types": ["T044"], "canonical_name": "malonyl-CoA methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester. [GOC:pz, RHEA:17105]"}
{"concept_id": "C4691274", "aliases": [], "types": ["T026"], "canonical_name": "pathogen-occupied vacuole"}
{"concept_id": "C4691275", "aliases": [], "types": ["T043"], "canonical_name": "histidine transmembrane import into vacuole"}
{"concept_id": "C4760861", "aliases": ["down-regulation of DNA helicase activity", "downregulation of DNA helicase activity", "down regulation of ATP-dependent DNA helicase activity", "downregulation of ATP-dependent DNA helicase activity", "down-regulation of ATP-dependent DNA helicase activity"], "types": ["T045"], "canonical_name": "down regulation of DNA helicase activity"}
{"concept_id": "C4760862", "aliases": ["up regulation of ATP-dependent DNA helicase activity", "upregulation of DNA helicase activity", "up-regulation of ATP-dependent DNA helicase activity", "upregulation of ATP-dependent DNA helicase activity", "up-regulation of DNA helicase activity"], "types": ["T044"], "canonical_name": "up regulation of DNA helicase activity"}
{"concept_id": "C4761336", "aliases": ["photoreceptor DCC", "DCC"], "types": ["T026"], "definition": "The distal region of the photoreceptor connecting cilium is structurally unique to the photoreceptor and is maintained by retina-specific protein, SPATA7, and its interacting partners RPGR and RPGRIP1. It is essential for photoreceptor sensory cilium stability. [GOC:krc, PMID:29899041]", "canonical_name": "photoreceptor distal connecting cilium"}
{"concept_id": "C4761342", "aliases": ["photoreceptor PCC", "photoreceptor proximal connecting cilium"], "types": ["T026"], "definition": "The proximal region of the photoreceptor connecting cilium is similar to the transition zone of unspecialized primary cilia and houses several major transition zone complexes, including NPHP, MKS, and RPGR. [GOC:krc, PMID:29899041]", "canonical_name": "PCC"}
{"concept_id": "C4761483", "aliases": ["sterol transfer activity"], "types": ["T044"], "definition": "Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]", "canonical_name": "sterol carrier activity"}
{"concept_id": "C5137135", "aliases": ["cell separation after cytokinesis"], "types": ["T043"], "canonical_name": "mitotic cytokinetic cell separation"}
{"concept_id": "C5137136", "aliases": [], "types": ["T043"], "canonical_name": "daughter cell separation"}
{"concept_id": "C5137137", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type DNA binding transcription repressor activity"}
{"concept_id": "C5137138", "aliases": [], "types": ["T045"], "canonical_name": "cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription"}
{"concept_id": "C5137139", "aliases": [], "types": ["T045"], "canonical_name": "copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription"}
{"concept_id": "C5137140", "aliases": [], "types": ["T045"], "canonical_name": "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription"}
{"concept_id": "C5137141", "aliases": [], "types": ["T045"], "canonical_name": "distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific"}
{"concept_id": "C5137142", "aliases": [], "types": ["T045"], "canonical_name": "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription"}
{"concept_id": "C5137143", "aliases": [], "types": ["T045"], "canonical_name": "metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription"}
{"concept_id": "C5137144", "aliases": [], "types": ["T045"], "canonical_name": "proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific"}
{"concept_id": "C5137145", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription"}
{"concept_id": "C5137146", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription"}
{"concept_id": "C5137147", "aliases": [], "types": ["T045"], "canonical_name": "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription"}
{"concept_id": "C5137148", "aliases": [], "types": ["T045"], "canonical_name": "distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific"}
{"concept_id": "C5137149", "aliases": [], "types": ["T045"], "canonical_name": "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription"}
{"concept_id": "C5137150", "aliases": [], "types": ["T045"], "canonical_name": "metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription"}
{"concept_id": "C5137151", "aliases": [], "types": ["T045"], "canonical_name": "proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific"}
{"concept_id": "C5137152", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription"}
{"concept_id": "C5137153", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription"}
{"concept_id": "C5137154", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type DNA binding transcription factor activity"}
{"concept_id": "C5137155", "aliases": [], "types": ["T044"], "canonical_name": "1,25-(OH)2D3 receptor activity"}
{"concept_id": "C5137156", "aliases": [], "types": ["T044"], "canonical_name": "9-cis retinoic acid receptor activity"}
{"concept_id": "C5137157", "aliases": [], "types": ["T044"], "canonical_name": "calcitriol receptor activity"}
{"concept_id": "C5137158", "aliases": [], "types": ["T044"], "canonical_name": "retinoid-X receptor activity"}
{"concept_id": "C5137159", "aliases": [], "types": ["T044"], "canonical_name": "vitamin D3 receptor activity"}
{"concept_id": "C5137160", "aliases": ["core extracellular matrix"], "types": ["T044"], "canonical_name": "core extracellular matrix"}
{"concept_id": "C5137161", "aliases": ["core matrisome"], "types": ["T044"], "canonical_name": "core matrisome"}
{"concept_id": "C5137162", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled calcium transmembrane transporter activity"}
{"concept_id": "C5137164", "aliases": [], "types": ["T043"], "canonical_name": "SAC-independent checkpoint"}
{"concept_id": "C5137165", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane phosphatidylinositol transfer activity"}
{"concept_id": "C5137166", "aliases": [], "types": ["T044"], "canonical_name": "hydrogen-exporting ATPase activity"}
{"concept_id": "C5137167", "aliases": [], "types": ["T044"], "canonical_name": "P-type H(+)-exporting ATPase activity"}
{"concept_id": "C5137168", "aliases": [], "types": ["T044"], "canonical_name": "proton-exporting ATPase activity"}
{"concept_id": "C5137169", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled potassium transmembrane transporter activity"}
{"concept_id": "C5137170", "aliases": [], "types": ["T044"], "canonical_name": "H(+)-exporting diphosphatase"}
{"concept_id": "C5137171", "aliases": [], "types": ["T044"], "canonical_name": "proton-pumping diphosphatase"}
{"concept_id": "C5137172", "aliases": [], "types": ["T044"], "canonical_name": "proton-pumping pyrophosphatase"}
{"concept_id": "C5137173", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled manganese transmembrane transporter activity"}
{"concept_id": "C5137174", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled intramembrane lipopolysaccharide transporter activity"}
{"concept_id": "C5137175", "aliases": [], "types": ["T043"], "canonical_name": "intracellular copper ion delivery"}
{"concept_id": "C5137176", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane glycolipid transfer activity"}
{"concept_id": "C5137177", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane glycolipid transporter activity"}
{"concept_id": "C5137178", "aliases": ["positive regulation of decapentaplegic receptor signalling pathway"], "types": ["T044"], "canonical_name": "positive regulation of decapentaplegic receptor signaling pathway"}
{"concept_id": "C5137179", "aliases": [], "types": ["T024"], "canonical_name": "matrisome"}
{"concept_id": "C5137182", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent sterol transmembrane transporter activity"}
{"concept_id": "C5137183", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent intramembrane glycolipid transporter activity"}
{"concept_id": "C5137184", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled intramembrane glycolipid transporter activity"}
{"concept_id": "C5137189", "aliases": ["mitochondrial protein translocase complex location"], "types": ["T026"], "canonical_name": "mitochondrial protein translocase complex"}
{"concept_id": "C5137190", "aliases": ["Mus81-Eme1 holliday resolvase complex location"], "types": ["T026"], "canonical_name": "Mus81-Eme1 holliday resolvase complex"}
{"concept_id": "C5137191", "aliases": ["Mus81-Eme2 complex location", "Mus81-Eme2 complex"], "types": ["T026"], "canonical_name": "Mus81-Eme2 complex"}
{"concept_id": "C5137192", "aliases": ["Mus81-Eme2 holliday resolvase complex location"], "types": ["T026"], "canonical_name": "Mus81-Eme2 holliday resolvase complex"}
{"concept_id": "C5137193", "aliases": [], "types": ["T040"], "canonical_name": "host-induced regulation of intestinal microbiota composition"}
{"concept_id": "C5137195", "aliases": ["SLBP-MIF4GD complex location"], "types": ["T026"], "canonical_name": "SLBP-MIF4GD complex"}
{"concept_id": "C5137196", "aliases": ["SLBP-SLIP1 complex location"], "types": ["T026"], "canonical_name": "SLBP-SLIP1 complex"}
{"concept_id": "C5137197", "aliases": ["paaABCE complex location"], "types": ["T026"], "canonical_name": "paaABCE complex"}
{"concept_id": "C5137198", "aliases": ["TGF-beta1 ligand-receptor complex location"], "types": ["T026"], "canonical_name": "TGF-beta1 ligand-receptor complex"}
{"concept_id": "C5137199", "aliases": ["TGF-beta1-beta2 ligand-receptor complex location"], "types": ["T026"], "canonical_name": "TGF-beta1-beta2 ligand-receptor complex"}
{"concept_id": "C5137200", "aliases": ["TGF-beta2 ligand-receptor complex location"], "types": ["T026"], "canonical_name": "TGF-beta2 ligand-receptor complex"}
{"concept_id": "C5137201", "aliases": ["TGFbeta1 ligand-receptor complex location"], "types": ["T026"], "canonical_name": "TGFbeta1 ligand-receptor complex"}
{"concept_id": "C5137202", "aliases": ["TGFbeta1-beta2 ligand-receptor complex location"], "types": ["T026"], "canonical_name": "TGFbeta1-beta2 ligand-receptor complex"}
{"concept_id": "C5137203", "aliases": ["TGFbeta2 ligand-receptor complex location"], "types": ["T026"], "canonical_name": "TGFbeta2 ligand-receptor complex"}
{"concept_id": "C5137204", "aliases": ["cyclin-dependent kinase 9 (Cdk9)-cyclin T1 complex location"], "types": ["T026"], "canonical_name": "cyclin-dependent kinase 9 (Cdk9)-cyclin T1 complex"}
{"concept_id": "C5137205", "aliases": ["cyclin-dependent kinase 9 (Cdk9)-cyclin T2 complex location"], "types": ["T026"], "canonical_name": "cyclin-dependent kinase 9 (Cdk9)-cyclin T2 complex"}
{"concept_id": "C5137206", "aliases": [], "types": ["T026"], "canonical_name": "shmoo tip membrane"}
{"concept_id": "C5137207", "aliases": ["positive regulation by symbiont of host autophagotic process"], "types": ["T043"], "canonical_name": "positive regulation by symbiont of host autophagy", "definition": "Any process in which a symbiont organism increases the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C5137208", "aliases": ["modulation by symbiont of host autophagic process"], "types": ["T043"], "canonical_name": "modulation by symbiont of host autophagy", "definition": "Any process in which a symbiont organism modulates the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C5137209", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent phosphatidylcholine transporter activity"}
{"concept_id": "C5137210", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled phosphatidylcholine transporter activity"}
{"concept_id": "C5137211", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent phosphatidylethanolamine transporter activity"}
{"concept_id": "C5137212", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled phosphatidylethanolamine transporter activity"}
{"concept_id": "C5137213", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled phosphatidylserine transporter activity"}
{"concept_id": "C5137214", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-dependent phosphatidylserine transporter activity"}
{"concept_id": "C5137215", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent ceramide transporter activity"}
{"concept_id": "C5137216", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled ceramide transporter activity"}
{"concept_id": "C5137217", "aliases": ["glycerophosphocholine O-acyltransferase activity", "GPACT activity"], "types": ["T044"], "canonical_name": "glycero-3-phosphocholine acyltransferase activity", "definition": "Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine. [PMID:18430972, PMID:27758859, RHEA:58476]"}
{"concept_id": "C5137220", "aliases": [], "types": ["T044"], "canonical_name": "sphingolipid carrier activity"}
{"concept_id": "C5137221", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane phosphatidylcholine transfer activity"}
{"concept_id": "C5137222", "aliases": ["IFT B complex binding", "intraflagellar transport complex B binding", "intraciliary transport complex B binding", "intraflagellar transport particle B binding"], "types": ["T044"], "canonical_name": "intraciliary transport particle B binding", "definition": "Binding to an intraciliary transport particle B (IFT B) complex. [PMID:20889716]"}
{"concept_id": "C5137223", "aliases": ["SHRED pathway"], "types": ["T043"], "canonical_name": "stress-induced homeostatically regulated protein degradation pathway", "definition": "A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway. [GOC:rl, GOC:rn, PMID:29861160]"}
{"concept_id": "C5137224", "aliases": ["downregulation of RNA polymerase II transcription termination factor activity", "down-regulation of RNA polymerase II transcription termination factor activity"], "types": ["T045"], "canonical_name": "down regulation of RNA polymerase II transcription termination factor activity"}
{"concept_id": "C5137225", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of RNA polymerase II transcription termination factor activity"}
{"concept_id": "C5137226", "aliases": [], "types": ["T045"], "canonical_name": "repression of RNA 3'-end formation by RNA polymerase II"}
{"concept_id": "C5137227", "aliases": ["repression of termination of RNA polymerase II transcription"], "types": ["T045"], "canonical_name": "repression of RNA polymerase II transcription termination"}
{"concept_id": "C5137228", "aliases": [], "types": ["T045"], "canonical_name": "repression of RNA polymerase II transcription termination factor activity"}
{"concept_id": "C5137229", "aliases": [], "types": ["T045"], "canonical_name": "repression of transcription termination from Pol II promoter"}
{"concept_id": "C5137230", "aliases": [], "types": ["T045"], "canonical_name": "repression of transcription termination from RNA polymerase II promoter"}
{"concept_id": "C5137231", "aliases": ["positive regulation of division septum formation involved in mitotic cell cycle", "positive regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle", "positive regulation of septin assembly and septum formation involved in mitotic cell cycle", "positive regulation of formation of division septum involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "positive regulation of mitotic division septum assembly", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. [PMID:22786806]"}
{"concept_id": "C5137232", "aliases": [], "types": ["T044"], "canonical_name": "innate receptor ligand activity"}
{"concept_id": "C5137233", "aliases": ["protein carrier activity"], "types": ["T044"], "canonical_name": "protein carrier chaperone", "definition": "Binding to and carrying a protein between two different cellular components by moving along with the target protein. [PMID:7628437]"}
{"concept_id": "C5137234", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled phospholipid transporter activity"}
{"concept_id": "C5137235", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-dependent phospholipid transporter activity"}
{"concept_id": "C5137236", "aliases": [], "types": ["T044"], "canonical_name": "phospholipid flippase activity"}
{"concept_id": "C5137237", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane phosphatidylserine carrier activity"}
{"concept_id": "C5137238", "aliases": [], "types": ["T044"], "canonical_name": "galactocerebroside flippase activity"}
{"concept_id": "C5137239", "aliases": [], "types": ["T044"], "canonical_name": "galactosylceramide flippase activity"}
{"concept_id": "C5137240", "aliases": [], "types": ["T044"], "canonical_name": "glucosylceramide flippase activity"}
{"concept_id": "C5137241", "aliases": [], "types": ["T043"], "canonical_name": "lipid efflux"}
{"concept_id": "C5137242", "aliases": [], "types": ["T043"], "canonical_name": "lipid uptake"}
{"concept_id": "C5137243", "aliases": ["cargo"], "types": ["T044"], "canonical_name": "cargo receptor ligand activity", "definition": "The activity of a gene product that interacts with a cargo receptor and initiates endocytosis. [PMID:15797858]"}
{"concept_id": "C5137244", "aliases": [], "types": ["T042"], "canonical_name": "optic pathway development"}
{"concept_id": "C5137245", "aliases": ["visual pathway development"], "types": ["T042"], "canonical_name": "visual system development", "definition": "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727]"}
{"concept_id": "C5137246", "aliases": [], "types": ["T042"], "canonical_name": "binocular vision development"}
{"concept_id": "C5137247", "aliases": [], "types": ["T042"], "canonical_name": "eye-specific patterning"}
{"concept_id": "C5137248", "aliases": [], "types": ["T042"], "canonical_name": "eye-specific segregation"}
{"concept_id": "C5137249", "aliases": ["multiple synapse", "multisynapse"], "types": ["T026"], "canonical_name": "multi-synapse"}
{"concept_id": "C5137250", "aliases": ["multisynapse organization", "multi-synaptic organization", "multisynaptic organisation", "multisynaptic organization", "multi-synaptic organisation", "multisynapse organisation", "multi-synapse organization"], "types": ["T043"], "canonical_name": "multi-synapse organisation"}
{"concept_id": "C5137251", "aliases": [], "types": ["T042"], "canonical_name": "homeostatic synaptic scaling"}
{"concept_id": "C5137252", "aliases": [], "types": ["T042"], "canonical_name": "regulation of homeostatic synaptic scaling"}
{"concept_id": "C5137253", "aliases": [], "types": ["T043"], "canonical_name": "amyloid-beta clearance by phagocytosis"}
{"concept_id": "C5137255", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane ceramide 1-phosphate transfer activity"}
{"concept_id": "C5137256", "aliases": [], "types": ["T044"], "canonical_name": "siderophore binding"}
{"concept_id": "C5137257", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane phosphatidylethanolamine transfer activity"}
{"concept_id": "C5137258", "aliases": ["tryptase complex location"], "types": ["T026"], "canonical_name": "tryptase complex"}
{"concept_id": "C5137259", "aliases": [], "types": ["T043"], "canonical_name": "regulation of xenobiotic transmembrane export"}
{"concept_id": "C5137260", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of xenobiotic transmembrane export"}
{"concept_id": "C5137261", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of xenobiotic transmembrane export"}
{"concept_id": "C5137262", "aliases": [], "types": ["T044"], "canonical_name": "intermembrane phosphatidic acid transfer activity"}
{"concept_id": "C5137263", "aliases": ["protein kinase 5 complex location"], "types": ["T026"], "canonical_name": "protein kinase 5 complex", "definition": "A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent. [PMID:15689152]"}
{"concept_id": "C5137264", "aliases": ["protein phosphatase inhibitor complex location"], "types": ["T026"], "canonical_name": "protein phosphatase inhibitor complex", "definition": "A protein-containing complex that inhibits protein phosphatase activity by directly binding to a protein phosphatase. [GOC:bhm, PMID:19407142, PMID:19933100]"}
{"concept_id": "C5137265", "aliases": ["Pi Mi complex location"], "types": ["T026"], "canonical_name": "Pi Mi complex", "definition": "A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis. [PMID:30089908]"}
{"concept_id": "C5137266", "aliases": ["histone mRNA stem-loop binding complex location"], "types": ["T026"], "canonical_name": "histone mRNA stem-loop binding complex", "definition": "A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export. [GOC:bhm, PMID:18025107, PMID:23286197]"}
{"concept_id": "C5137267", "aliases": ["phenylacetyl-CoA 1,2-epoxidase complex location"], "types": ["T026"], "canonical_name": "phenylacetyl-CoA 1,2-epoxidase complex", "definition": "A protein complex capable of catalysing the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+). [GOC:bhm, PMID:21247899]"}
{"concept_id": "C5137268", "aliases": ["ATG2-ATG18 complex location"], "types": ["T026"], "canonical_name": "ATG2-ATG18 complex", "definition": "A protein complex essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Functions at a late step of autophagosome formation for efficient completion of sequestration, probably through facilitating recruitment of ATG8-phosphatidylethanolamine (PE) to the preautophagosomal structure (PAS) and/or its protection from deconjugation by ATG4. Composed of ATG2 and ATG18 in Saccharomyces cerevisiae. [GOC:bhm, PMID:23230146]"}
{"concept_id": "C5137269", "aliases": ["TIC complex location associated chloroplast protein import motor", "Ycf2/FtsHi complex location", "TIC complex associated chloroplast protein import motor"], "types": ["T026"], "canonical_name": "Ycf2/FtsHi complex", "definition": "A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma. [PMID:30309901]"}
{"concept_id": "C5137270", "aliases": ["Yae1-Lto1 complex location"], "types": ["T026"], "canonical_name": "Yae1-Lto1 complex", "definition": "A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p. [PMID:26182403]"}
{"concept_id": "C5137271", "aliases": ["LinE complex location"], "types": ["T026"], "canonical_name": "LinE complex", "definition": "A protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins. [PMID:30640914]"}
{"concept_id": "C5137272", "aliases": ["TGFb ligand-receptor complex", "TGF-beta ligand-receptor complex location", "TGFbeta ligand-receptor complex", "transforming growth factor beta ligand-receptor complex location", "TGF-beta ligand-receptor complex", "TGFb ligand-receptor complex location", "TGFbeta ligand-receptor complex location"], "types": ["T026"], "canonical_name": "transforming growth factor beta ligand-receptor complex", "definition": "A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand. [Reactome:R-HSA-170840]"}
{"concept_id": "C5137273", "aliases": ["tRNA (m7G46) methyltransferase complex location", "tRNA (m7G46) methyltransferase", "Trm8-Trm82 complex location", "tRNA m7G methylation complex", "Trm8-Trm82 complex", "tRNA m7G methylation complex location"], "types": ["T026"], "canonical_name": "tRNA (m7G46) methyltransferase complex", "definition": "A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat). [GOC:vw, PMID:15811913, PMID:1738232, PMID:18164779, PMID:18184583]"}
{"concept_id": "C5137274", "aliases": ["interphase cortical node", "Cdr2 medial cortical node complex location", "interphase node"], "types": ["T026"], "canonical_name": "Cdr2 medial cortical node complex", "definition": "A megadalton-sized complex at the medial cortex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent localization and phosphorylation of Wee1 during interphase. [GOC:vw, PMID:29514920]"}
{"concept_id": "C5137275", "aliases": ["SHREC2 complex location"], "types": ["T026"], "canonical_name": "SHREC2 complex", "definition": "A histone deacetylase complex formed by the association of an HP1 protein with a SHREC complex. The SHREC2 complex is required for deacetylation of H3K14, and mediates transcriptional gene silencing by limiting RNA polymerase II access to heterochromatin. In fission yeast, the complex contains the SHREC subunits Clr1, Clr2, Clr3, and Mit1, and the HP1 protein Chp2. [GOC:mah, PMID:19111658]"}
{"concept_id": "C5137276", "aliases": ["Aim21-Tda2 complex location", "Aim21/Tda2 complex", "Aim21/Tda2 complex location"], "types": ["T026"], "canonical_name": "Aim21-Tda2 complex", "definition": "A complex that localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. The Aim21-Tda2 complex is necessary for efficient endocytosis and balancing the distribution of actin between patches and cables. [GOC:rn, PMID:28706108, PMID:29467252]"}
{"concept_id": "C5137277", "aliases": ["ubiquinone biosynthesis complex location", "Ubi complex location", "CoQ metabolon", "Ubi complex"], "types": ["T026"], "canonical_name": "ubiquinone biosynthesis complex", "definition": "The cytosolic ubiquinone biosynthesis complex is composed of enzymes and accessory factors of the ubiquinone biosynthesis pathway and enables synthesis of the extremely hydrophobic molecule ubiquinone. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K. [GOC:imk, PMID:27060254, PMID:28927698, PMID:30686758]"}
{"concept_id": "C5137278", "aliases": ["CDC24-FAR1-BG complex location", "CDC24-FAR1-BG complex", "Cdc24p-Far1p-BG complex", "CDC24-FAR1-Gbetagamma complex", "Cdc24p-Far1p-BG complex location", "CDC24-FAR1-Gbetagamma complex location", "Cdc24p-Far1p-Gbetagamma complex location"], "types": ["T026"], "canonical_name": "Cdc24p-Far1p-Gbetagamma complex", "definition": "A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit). [PMID:10087263]"}
{"concept_id": "C5137279", "aliases": ["SLAC complex location"], "types": ["T026"], "canonical_name": "SLAC complex", "definition": "A protein complex that regulates Arp2/3 complex-mediated actin nucleation. [GOC:lnp, PMID:22973053]"}
{"concept_id": "C5137280", "aliases": ["Top3-beta-TDRD3 complex", "DNA topoisomerase III-beta-TDRD3 complex location", "Top3-beta-TDRD3 complex location"], "types": ["T026"], "canonical_name": "DNA topoisomerase III-beta-TDRD3 complex", "definition": "A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities. [GOC:lnp, PMID:23912945, PMID:28176834]"}
{"concept_id": "C5137281", "aliases": ["MIB complex location", "mitochondrial intermembrane space bridging complex", "mitochondrial intermembrane space bridging complex location", "mitofilin complex location", "mitofilin complex"], "types": ["T026"], "canonical_name": "MIB complex", "definition": "A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1. [PMID:26477565]"}
{"concept_id": "C5137282", "aliases": ["GBAF complex location"], "types": ["T026"], "canonical_name": "GBAF complex", "definition": "A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM. [PMID:29374058]"}
{"concept_id": "C5137283", "aliases": ["amylin receptor complex location 1", "AMY1 complex", "AMY1 complex location"], "types": ["T026"], "canonical_name": "amylin receptor complex 1", "definition": "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM). [GOC:aruk, GOC:bc, PMID:22500019]"}
{"concept_id": "C5137284", "aliases": ["AMY2 complex", "AMY2 complex location", "amylin receptor complex location 2"], "types": ["T026"], "canonical_name": "amylin receptor complex 2", "definition": "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM). [GOC:aruk, GOC:bc, PMID:22500019]"}
{"concept_id": "C5137285", "aliases": ["AMY3 complex location", "AMY3 complex", "amylin receptor complex location 3"], "types": ["T026"], "canonical_name": "amylin receptor complex 3", "definition": "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 3. Amylin receptor complex 3 (AMY3) also serves as a receptor for the amyloid-beta complex. Ligand binding to AMY3 results in increased cytosolic calcium ion levels and in activation on multiple intracellular signalling pathways. [GOC:aruk, GOC:bc, PMID:22500019]"}
{"concept_id": "C5137286", "aliases": ["RPB4-RPB7 complex location"], "types": ["T026"], "canonical_name": "RPB4-RPB7 complex", "definition": "A protein complex that cycles between the nucleus where it is part of the RNA polymerase II and the cytoplasmic mRNA processing body where it mediates the two major cytoplasmic mRNA decay pathways. [GOC:bhm, PMID:15591044]"}
{"concept_id": "C5137287", "aliases": ["BCOR/BCORL1 complex", "non-canonical PRC1-BCOR complex location", "non-canonical BCOR-PRC1.1 complex location", "BCL6 corepressor (BCOR) complex", "PRC1.1 complex location", "non-canonical BCOR-PRC1.1 complex", "BCOR complex location", "PRC1.1 complex", "BCL6 corepressor (BCOR) complex location", "non-canonical PRC1-BCOR complex", "BCOR/BCORL1 complex location"], "types": ["T026"], "canonical_name": "BCOR complex", "definition": "A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10. [PMID:16943429, PMID:22325352, PMID:24515802]"}
{"concept_id": "C5137314", "aliases": [], "types": ["T045"], "canonical_name": "DNA template activity", "definition": "Binding to nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule. [GOC:krc]"}
{"concept_id": "C5137315", "aliases": ["RNA polymerase III general initiation factor activity"], "types": ["T044"], "canonical_name": "RNA polymerase III general transcription initiation factor activity", "definition": "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III. [GOC:txnOH-2018, PMID:12381659, PMID:17977614, PMID:20413673, PMID:27068803, Wikipedia:RNA_polymerase_III]"}
{"concept_id": "C5137316", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III general transcription initiation factor binding", "definition": "Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III. [GOC:txnOH]"}
{"concept_id": "C5137317", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I general transcription initiation factor binding", "definition": "Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I. [GOC:txnOH]"}
{"concept_id": "C5137318", "aliases": ["RNA polymerase I transcription general initiation factor activity", "general RNA polymerase I transcription factor activity"], "types": ["T044"], "canonical_name": "RNA polymerase I general transcription initiation factor activity", "definition": "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs. [GOC:txnOH-2018, PMID:11500378, PMID:17972917, PMID:25346433, PMID:28340337, PMID:28842442, PMID:31358304]"}
{"concept_id": "C5137319", "aliases": [], "types": ["T045"], "canonical_name": "DNA-binding transcription activator activity", "definition": "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. [GOC:txnOH-2018]"}
{"concept_id": "C5137320", "aliases": [], "types": ["T045"], "canonical_name": "DNA-binding transcription repressor activity", "definition": "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. [GOC:txnOH-2018]"}
{"concept_id": "C5137321", "aliases": [], "types": ["T043"], "canonical_name": "epithelial cilium movement involved in extracellular fluid movement", "definition": "The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid. [GOC:dph, GOC:krc]"}
{"concept_id": "C5137322", "aliases": [], "types": ["T040"], "canonical_name": "respiratory gaseous exchange by respiratory system", "definition": "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. [ISBN:0198506732]"}
{"concept_id": "C5137323", "aliases": [], "types": ["T043"], "canonical_name": "cell population proliferation", "definition": "The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]"}
{"concept_id": "C5137324", "aliases": ["phosphatidylinositol carrier activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol transfer activity", "definition": "Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C5137325", "aliases": [], "types": ["T044"], "canonical_name": "aminophospholipid flippase activity", "definition": "Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. [GOC:pg]"}
{"concept_id": "C5137326", "aliases": ["ATP-dependent bile acid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled bile acid transmembrane transporter activity"}
{"concept_id": "C5137327", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled putrescine transmembrane transporter activity"}
{"concept_id": "C5137329", "aliases": [], "types": ["T043"], "canonical_name": "ferric-enterobactin import into cell", "definition": "A process in which ferric-enterobactin, the iron-bound form of the siderophore enterobactin, is transported into the cell by specific cell surface receptors. [GOC:pg, PMID:23192658]"}
{"concept_id": "C5137330", "aliases": [], "types": ["T043"], "canonical_name": "ferric triacetylfusarinine C import into cell", "definition": "The directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]"}
{"concept_id": "C5137331", "aliases": [], "types": ["T043"], "canonical_name": "ferric-hydroxamate import into cell", "definition": "A process in which ferric-hydroxamate, the iron-bound form of the iron chelator hydroxamate, is transported into the cell by specific cell surface receptors. [GOC:pg, PMID:23192658]"}
{"concept_id": "C5137332", "aliases": [], "types": ["T044"], "canonical_name": "tetracycline transmembrane transport", "definition": "The directed movement of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). [GOC:curators]"}
{"concept_id": "C5137333", "aliases": [], "types": ["T044"], "canonical_name": "bicyclomycin transmembrane transport", "definition": "The directed movement of bicyclomycin across a lipid bilayer, from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive. [PMID:20067529]"}
{"concept_id": "C5137334", "aliases": ["glycolipid carrier activity"], "types": ["T044"], "canonical_name": "glycolipid transfer activity", "definition": "Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid. [PMID:30337668]"}
{"concept_id": "C5137335", "aliases": ["signalling receptor activator activity"], "types": ["T044"], "canonical_name": "signaling receptor activator activity", "definition": "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. [GOC:ceb]"}
{"concept_id": "C5137336", "aliases": [], "types": ["T044"], "canonical_name": "2'-deoxyguanosine DNA ADP-ribosyltransferase activity", "definition": "Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form. [PMID:11592983]"}
{"concept_id": "C5137338", "aliases": ["gene silencing by RNA, production of guide RNA", "gene silencing by RNA, production of small RNA", "primary sncRNA processing", "scnRNA processing"], "types": ["T045"], "canonical_name": "small regulatory ncRNA processing", "definition": "A process leading to the generation of a functional small regulatory non-coding RNA. [GOC:mah, PMID:15196465, PMID:19239886]"}
{"concept_id": "C5137340", "aliases": ["ATP-dependent lipid transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled lipid transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out). [GOC:BHF, GOC:rl]"}
{"concept_id": "C5137341", "aliases": ["ATP-coupled sterol transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ATPase-coupled sterol transmembrane transporter activity"}
{"concept_id": "C5137342", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell population proliferation", "definition": "Any process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]"}
{"concept_id": "C5137343", "aliases": [], "types": ["T043"], "canonical_name": "chloramphenicol transmembrane transport", "definition": "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, across a lipid bilayer, from one side of a membrane to the other. [PMID:29150447]"}
{"concept_id": "C5137344", "aliases": [], "types": ["T043"], "canonical_name": "ferrichrome import into cell", "definition": "A process in which ferrichrome is transported into the cell by specific cell surface receptors. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. [GOC:jl, ISBN:0198506732, PMID:23192658]"}
{"concept_id": "C5137345", "aliases": [], "types": ["T040"], "canonical_name": "host-mediated regulation of intestinal microbiota composition", "definition": "The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut. [PMID:25757720]"}
{"concept_id": "C5137346", "aliases": [], "types": ["T044"], "canonical_name": "lysophospholipid:sodium symporter activity", "definition": "Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids. [GOC:ai]"}
{"concept_id": "C5137347", "aliases": [], "types": ["T043"], "canonical_name": "basement membrane disassembly involved in semicircular canal fusion", "definition": "A process that results in the breakdown of the basement membrane that contributes to the process of semicircular canal fusion. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C5137348", "aliases": [], "types": ["T043"], "canonical_name": "regulation of basement membrane disassembly involved in semicircular canal fusion by cell communication", "definition": "Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basement membrane disassembly involved in semicircular canal fusion. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C5137349", "aliases": [], "types": ["T044"], "canonical_name": "GPI-mannose ethanolamine phosphate phosphodiesterase activity", "definition": "A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor. [PMID:19837036]"}
{"concept_id": "C5137350", "aliases": [], "types": ["T026"], "canonical_name": "lipopolysaccharide transport system", "definition": "A protein-containing complex that functions to transport lipopolysaccharide from its site of synthesis at the cytoplasmic membrane across the periplasm to the outer membrane in an ATP-dependent manner. [PMID:29449493]"}
{"concept_id": "C5137351", "aliases": [], "types": ["T044"], "canonical_name": "starch granule initiation", "definition": "The sequence of events that initiates (or primes) the synthesis of semi-crystalline starch granules within photosynthetic chloroplasts or non-photosynthetic amyloplasts. [PMID:28684429]"}
{"concept_id": "C5137352", "aliases": [], "types": ["T044"], "canonical_name": "fluoride channel activity", "definition": "Enables the facilitated diffusion of fluoride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [PMID:23991286, PMID:25156118]"}
{"concept_id": "C5137353", "aliases": [], "types": ["T043"], "canonical_name": "photosynthetic state transition", "definition": "A regulation of the phtosynthetic light reaction in which the light harvesting antenna complexes transition between photosystems. [PMID:29967049]"}
{"concept_id": "C5137354", "aliases": [], "types": ["T043"], "canonical_name": "compound eye pigment cell differentiation", "definition": "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye pigment cell, a cell of the retina containing screening pigments that functions to screen photoreceptors from light leaking from adjacent ommatidia. [GOC:ha, PMID:8929534]"}
{"concept_id": "C5137355", "aliases": [], "types": ["T044"], "canonical_name": "L-aspartate:fumarate antiporter activity", "definition": "Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out). [PMID:29995997]"}
{"concept_id": "C5137356", "aliases": [], "types": ["T044"], "canonical_name": "transcription factor TFIIH holo complex binding", "definition": "Binding to a transcription factor TFIIH holo complex. [PMID:11259578]"}
{"concept_id": "C5137357", "aliases": [], "types": ["T044"], "canonical_name": "FACT complex binding", "definition": "Binding to a FACT complex. [PMID:10682845]"}
{"concept_id": "C5137358", "aliases": [], "types": ["T044"], "canonical_name": "NuA4 histone acetyltransferase complex binding", "definition": "Binding to a NuA4 histone acetyltransferase complex. [PMID:15528408]"}
{"concept_id": "C5137359", "aliases": [], "types": ["T044"], "canonical_name": "TAP complex binding", "definition": "Binding to a TAP complex. [PMID:17947644]"}
{"concept_id": "C5137360", "aliases": [], "types": ["T044"], "canonical_name": "oligosaccharyltransferase complex binding", "definition": "Binding to an oligosaccharyltransferase complex. [PMID:12887896]"}
{"concept_id": "C5137361", "aliases": [], "types": ["T044"], "canonical_name": "BBSome binding", "definition": "Binding to a BBSome complex. [PMID:20603001]"}
{"concept_id": "C5137362", "aliases": [], "types": ["T045"], "canonical_name": "box C/D snoRNP complex binding", "definition": "Binding to a box C/D snoRNP complex. [PMID:10679015]"}
{"concept_id": "C5137363", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA snoRNP complex binding", "definition": "Binding to a box H/ACA snoRNP complex. [PMID:10679015]"}
{"concept_id": "C5137364", "aliases": [], "types": ["T044"], "canonical_name": "PSII associated light-harvesting complex II binding", "definition": "Binding to a PSII associated light-harvesting complex II. [PMID:17400553]"}
{"concept_id": "C5137365", "aliases": [], "types": ["T044"], "canonical_name": "chloroplast photosystem I binding", "definition": "Binding to a chloroplast photosystem I. [PMID:17400553]"}
{"concept_id": "C5137366", "aliases": [], "types": ["T044"], "canonical_name": "chloroplast photosystem II binding", "definition": "Binding to a chloroplast photosystem II. [PMID:17400553]"}
{"concept_id": "C5137367", "aliases": [], "types": ["T044"], "canonical_name": "GARP complex binding", "definition": "Binding to a GARP complex. [PMID:20163565]"}
{"concept_id": "C5137368", "aliases": [], "types": ["T044"], "canonical_name": "SAGA complex binding", "definition": "Binding to a SAGA complex. [PMID:27185460]"}
{"concept_id": "C5137369", "aliases": [], "types": ["T044"], "canonical_name": "H3K9me3 modified histone binding", "definition": "Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation. [PMID:30110338]"}
{"concept_id": "C5137370", "aliases": [], "types": ["T026"], "canonical_name": "pollen aperture", "definition": "An area where exine is reduced or absent, in the pollen wall. [PMID:30150313]"}
{"concept_id": "C5137371", "aliases": [], "types": ["T043"], "canonical_name": "pollen aperture formation", "definition": "The cellular component assembly process of forming pollen apertures, areas where exine is reduced or absent, in the pollen cell wall. [PMID:30150313]"}
{"concept_id": "C5137372", "aliases": ["acyl-CoA delta(5)-desaturase activity", "acyl-CoA D5-desaturase activity", "acyl-CoA delta5-desaturase activity"], "types": ["T044"], "definition": "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta5-acyl-CoA + acceptor + 2 H2O. [PMID:10601301, PMID:10769175, RHEA:46424]", "canonical_name": "acyl-CoA (8-3)-desaturase"}
{"concept_id": "C5137373", "aliases": ["tuberin-hamartin complex binding", "tuberin sclerosis complex binding"], "types": ["T044"], "canonical_name": "TSC1-TSC2 complex binding", "definition": "Binding to a TSC1-TSC2 complex. [PMID:28561066]"}
{"concept_id": "C5137374", "aliases": [], "types": ["T044"], "canonical_name": "inhibitory MHC class Ib receptor activity", "definition": "Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte. [DOI:10.1002/9780470015902.a0024246]"}
{"concept_id": "C5137375", "aliases": [], "types": ["T044"], "canonical_name": "activating MHC class Ib receptor activity", "definition": "Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte. [DOI:10.1002/9780470015902.a0024246]"}
{"concept_id": "C5137376", "aliases": [], "types": ["T044"], "canonical_name": "HLA-E specific inhibitory MHC class Ib receptor activity", "definition": "Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. [DOI:10.1002/9780470015902.a0024246]"}
{"concept_id": "C5137377", "aliases": [], "types": ["T044"], "canonical_name": "HLA-G specific inhibitory MHC class Ib receptor activity", "definition": "Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte. [DOI:10.1002/9780470015902.a0024246]"}
{"concept_id": "C5137378", "aliases": [], "types": ["T043"], "canonical_name": "regulation of capsule polysaccharide biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi. [PMID:21917918]"}
{"concept_id": "C5137379", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of capsule polysaccharide biosynthetic process", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi. [PMID:21917918]"}
{"concept_id": "C5137380", "aliases": [], "types": ["T040"], "canonical_name": "regulation of vein smooth muscle contraction", "definition": "Any process that modulates the frequency, rate or extent of vein smooth muscle contraction. [PMID:8428203]"}
{"concept_id": "C5137381", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of vein smooth muscle contraction", "definition": "Any process that increases the frequency, rate or extent of vein smooth muscle contraction. [PMID:8428203]"}
{"concept_id": "C5137382", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of vein smooth muscle contraction", "definition": "Any process that decreases the frequency, rate or extent of vein smooth muscle contraction. [PMID:8428203]"}
{"concept_id": "C5137383", "aliases": [], "types": ["T044"], "canonical_name": "regulation of taurine biosynthetic process", "definition": "Any process that modulates the rate, frequency or extent of taurine biosynthesis. [GOC:BHF, PMID:18648510, PMID:24911144]"}
{"concept_id": "C5137384", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of taurine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of taurine biosynthesis. [GOC:BHF, PMID:18648510, PMID:24911144]"}
{"concept_id": "C5137385", "aliases": [], "types": ["T042"], "canonical_name": "stomach development", "definition": "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. [PMID:11967278]"}
{"concept_id": "C5137386", "aliases": [], "types": ["T043"], "canonical_name": "endoplasmic reticulum-peroxisome tethering", "definition": "The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other. [PMID:28463579]"}
{"concept_id": "C5137387", "aliases": [], "types": ["T043"], "canonical_name": "kinetochore disassembly", "definition": "The disaggregation of a kinetochore into its constituent components. [GOC:mah, PMID:27611693]"}
{"concept_id": "C5137388", "aliases": [], "types": ["T043"], "canonical_name": "chemosynthesis", "definition": "The cellular metabolic process in which organic chemical compounds are synthesized from carbon-containing molecules and nutrients using energy obtained from the oxidation of inorganic compounds or methane. [PMID:25050523]"}
{"concept_id": "C5137389", "aliases": [], "types": ["T043"], "canonical_name": "regulation of programmed necrotic cell death", "definition": "Any process that modulates the frequency, rate or extent of programmed necrotic cell death. [GOC:aruk, GOC:rph, PMID:27258785]"}
{"concept_id": "C5137390", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of programmed necrotic cell death", "definition": "Any process that decreases the frequency, rate or extent of programmed necrotic cell death. [GOC:aruk, GOC:rph, PMID:27258785]"}
{"concept_id": "C5137391", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of programmed necrotic cell death", "definition": "Any process that increases the frequency, rate or extent of programmed necrotic cell death. [GOC:aruk, GOC:rph, PMID:27258785]"}
{"concept_id": "C5137392", "aliases": ["peptide-aspartate beta-dioxygenase activity"], "types": ["T044"], "canonical_name": "peptidyl-aspartic acid 3-dioxygenase activity", "definition": "Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2. [PMID:1378441, PMID:1856229, RHEA:11508]"}
{"concept_id": "C5137393", "aliases": [], "types": ["T043"], "canonical_name": "female germline stem cell symmetric division", "definition": "Division of a female germline stem cell to produce two germline stem cells of the same type as the parent. [GOC:ha, PMID:30248087]"}
{"concept_id": "C5137394", "aliases": ["dsRNA biosynthesis", "double-stranded RNA biosynthesis", "dsRNA biosynthetic process"], "types": ["T045"], "canonical_name": "double-stranded RNA biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of double-stranded RNA. [PMID:19701182]"}
{"concept_id": "C5137395", "aliases": ["PRE binding"], "types": ["T045"], "canonical_name": "pumilio-response element binding", "definition": "Binding to a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA. [PMID:30601114]"}
{"concept_id": "C5137396", "aliases": [], "types": ["T044"], "canonical_name": "RNA 2'-O-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide. [PMID:30626973, RHEA:58956]"}
{"concept_id": "C5137397", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein localization to non-growing cell tip", "definition": "Any process that modulates the frequency, rate or extent of protein localization to a non-growing cell tip. [PMID:18328707]"}
{"concept_id": "C5137398", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of protein localization to non-growing cell tip", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a non-growing cell tip. [PMID:18328707]"}
{"concept_id": "C5137399", "aliases": [], "types": ["T044"], "canonical_name": "regulation of DNA recombinase disassembly", "definition": "Any process that modulates the rate, frequency or extent of DNA recombinase disassembly, the disaggregation of a DNA recombinase complex into its constituent components. [PMID:30297419]"}
{"concept_id": "C5137400", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of DNA recombinase disassembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombinase complex disassembly, the disaggregation of a DNA recombinase complex into its constituent components. [PMID:30297419]"}
{"concept_id": "C5137401", "aliases": [], "types": ["T044"], "canonical_name": "zinc ion import into organelle", "definition": "The directed import of zinc(2+) from the cytosol, across an organelle membrane, into the organelle. [PMID:29529046]"}
{"concept_id": "C5137402", "aliases": ["FAPA biosynthesis", "FAPA biosynthetic process", "fatty acid amide biosynthesis"], "types": ["T040"], "canonical_name": "fatty acid primary amide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a fatty acid primary amide. [PMID:10079066, PMID:15952893]"}
{"concept_id": "C5137403", "aliases": ["early phagocytic vesicle lumen"], "types": ["T026"], "canonical_name": "early phagosome lumen", "definition": "The volume enclosed by the membrane of an eary phagosome. [PMID:18813294]"}
{"concept_id": "C5137404", "aliases": [], "types": ["T026"], "canonical_name": "phenyloplast", "definition": "A chloroplast-derived plastid in which the solid form of phenol is stored. [PMID:24683183]"}
{"concept_id": "C5137405", "aliases": [], "types": ["T043"], "canonical_name": "LinE complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components during meiotic prophase to form a LinE complex, the protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins. [PMID:30640914]"}
{"concept_id": "C5137406", "aliases": ["LinE focus formation", "LinE chromosome loading"], "types": ["T043"], "canonical_name": "linear element maturation", "definition": "The meiotic cell cycle chromosome organization process in which LinE complexes closely associate with chromatin during meiotic prophase to form mature linear elements. [PMID:30640914]"}
{"concept_id": "C5137407", "aliases": ["histone lysine N-methyltransferase activity (H3-K37 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-K37 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group onto lysine at position 37 of the histone H3 protein. [PMID:30773398]"}
{"concept_id": "C5137408", "aliases": [], "types": ["T043"], "canonical_name": "regulation of linear element maturation", "definition": "Any process that modulates the rate, frequency or extent of linear element maturation. [PMID:30640914]"}
{"concept_id": "C5137409", "aliases": ["gamma-hydroxybutyrate receptor activity"], "types": ["T044"], "canonical_name": "4-hydroxybutyrate receptor activity", "definition": "Combining with 4-hydroxybutyrte to initiate a change in cell activity. [PMID:17197387]"}
{"concept_id": "C5137410", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mitochondrial gene expression", "definition": "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [PMID:28285835]"}
{"concept_id": "C5137411", "aliases": ["primary fatty amide metabolic process"], "types": ["T044"], "canonical_name": "fatty acid primary amide metabolic process", "definition": "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform primary fatty amides. [PMID:11128635]"}
{"concept_id": "C5137412", "aliases": ["primary fatty amide catabolic process"], "types": ["T044"], "canonical_name": "fatty acid primary amide catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of primary fatty amides. [PMID:11128635]"}
{"concept_id": "C5137413", "aliases": ["phosphatidylcholine floppase activity (cytosolic to exoplasmic leaftlet)"], "types": ["T044"], "canonical_name": "phosphatidylcholine floppase activity", "definition": "Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [GOC:ab, PMID:16452632, RHEA:38583]"}
{"concept_id": "C5137414", "aliases": ["phosphatidylserine floppase activity (cytosolic to exoplasmic leaftlet)"], "types": ["T044"], "canonical_name": "phosphatidylserine floppase activity", "definition": "Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [GOC:ab, PMID:16452632, PMID:20224745, RHEA:38567]"}
{"concept_id": "C5137415", "aliases": ["ceramide floppase activity (cytosolic to exoplasmic leaftlet)"], "types": ["T044"], "canonical_name": "ceramide floppase activity", "definition": "Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [GOC:BHF, GOC:dos, GOC:rl]"}
{"concept_id": "C5137416", "aliases": [], "types": ["T044"], "canonical_name": "purine phosphoribosyltransferase activity", "definition": "Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate. [PMID:5123876]"}
{"concept_id": "C5137417", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of cardiac muscle cell contraction", "definition": "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell contraction. [PMID:19525381]"}
{"concept_id": "C5137418", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cardiac muscle cell contraction", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell contraction. [PMID:19525381]"}
{"concept_id": "C5137419", "aliases": ["LIMBI"], "types": ["T040"], "canonical_name": "lectin-induced modified bacterial internalization", "definition": "The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by secretion of lectins which bind to the bacterial surface. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:rjd, PMID:30049880]"}
{"concept_id": "C5137420", "aliases": [], "types": ["T044"], "canonical_name": "IkappaB kinase complex binding", "definition": "Binding to a IkappaB kinase complex. [GOC:pga, PMID:12492477]"}
{"concept_id": "C5137421", "aliases": [], "types": ["T044"], "canonical_name": "Sec61 translocon complex binding", "definition": "Binding to a Sec61 translocon complex. [GOC:pga, PMID:9792704]"}
{"concept_id": "C5137422", "aliases": ["endosymbiont cell surface"], "types": ["T026"], "canonical_name": "symbiont cell surface", "definition": "The cell surface of a secondary, endosymbiont organism with which the first organism is interacting. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:rjd, PMID:30049880]"}
{"concept_id": "C5137423", "aliases": [], "types": ["T044"], "canonical_name": "P-TEFb complex binding", "definition": "Binding to a P-TEFb complex. [GOC:pga, PMID:18391197]"}
{"concept_id": "C5137424", "aliases": [], "types": ["T044"], "canonical_name": "flavin prenyltransferase activity", "definition": "Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate. [GOC:imk, PMID:26083743]"}
{"concept_id": "C5137425", "aliases": ["25S rRNA (adenine(645)-N(1))-methyltransferase", "25S rRNA m(1)A(645) methyltransferase"], "types": ["T045"], "canonical_name": "rRNA (adenine-N1-)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA. [EC:2.1.1.287, PMID:23180764]"}
{"concept_id": "C5137426", "aliases": [], "types": ["T044"], "canonical_name": "fraxetin 5-hydroxylase activity", "definition": "Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20. [GOC:lr, PMID:29581584, RHEA:57844]"}
{"concept_id": "C5137427", "aliases": [], "types": ["T044"], "canonical_name": "scopoletin 8-hydroxylase activity", "definition": "Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2). [GOC:lr, PMID:29361149, PMID:29581584, RHEA:57848]"}
{"concept_id": "C5137428", "aliases": [], "types": ["T044"], "canonical_name": "sideretin biosynthesis", "definition": "The chemical reactions and pathways resulting in the formation of sideretin. [GOC:lr, PMID:29581584]"}
{"concept_id": "C5137429", "aliases": [], "types": ["T044"], "canonical_name": "fraxetin biosynthesis", "definition": "The chemical reactions and pathways resulting in the formation of fraxetin. [GOC:lr, PMID:29581584]"}
{"concept_id": "C5137430", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxyindole-3- carbonyl nitrile biosynthesis", "definition": "The chemical reactions and pathways resulting in the formation of 4-hydroxyindole-3- carbonyl nitrile (4-OH-ICN), a cyanogenic glucoside. [GOC:lr, PMID:26352477]"}
{"concept_id": "C5137431", "aliases": [], "types": ["T044"], "canonical_name": "indole-3-carbonyl nitrile 4-hydroxylase activity", "definition": "Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP(+) + H20. [GOC:lr, PMID:26352477, RHEA:57864]"}
{"concept_id": "C5137432", "aliases": [], "types": ["T044"], "canonical_name": "zearalenone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of zearalenone, a mycotoxin produced by several Fusarium species, is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals. [GOC:ach, PMID:16517624, PMID:20578001]"}
{"concept_id": "C5137433", "aliases": [], "types": ["T044"], "canonical_name": "CNBH domain intrinsic ligand binding", "definition": "Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide. [GOC:cvs, PMID:27025590, PMID:29567795]"}
{"concept_id": "C5137434", "aliases": [], "types": ["T044"], "canonical_name": "phosphorylated histone binding", "definition": "Binding to a histone in which a residue has been modified by phosphorylation. [GOC:mah, PMID:20679485]"}
{"concept_id": "C5137435", "aliases": [], "types": ["T040"], "canonical_name": "perithecium formation", "definition": "The process of producing flask-shaped fruiting bodies, called perithecia. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck. [DOI:10.1007/978-3-642-00286-1_2, GOC:ach, PMID:19547974, PMID:21134480, PMID:25311923]"}
{"concept_id": "C5137436", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine 3-dioxygenase activity", "definition": "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2. [GOC:al, PMID:29915238, RHEA:57152]"}
{"concept_id": "C5137437", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine 4-dioxygenase activity", "definition": "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2. [GOC:pde, PMID:24486019, RHEA:57156]"}
{"concept_id": "C5137438", "aliases": ["L-arginine 3-hydroxylase activity"], "types": ["T044"], "canonical_name": "peptidyl-arginine 3-dioxygenase activity", "definition": "Catalyzes the reaction: 2-oxoglutarate + [protein]-L-arginine + O2 = [protein]-(3R)-3-hydroxy-L-arginine + CO2 + succinate. [PMID:29563586]"}
{"concept_id": "C5137442", "aliases": [], "types": ["T044"], "canonical_name": "mRNA N-acetyltransferase activity", "definition": "Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate. [GOC:sp, PMID:30449621]"}
{"concept_id": "C5137443", "aliases": [], "types": ["T044"], "canonical_name": "regulation of exonucleolytic catabolism of deadenylated mRNA", "definition": "Any process that modulates the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay. [GOC:vw, PMID:30601114]"}
{"concept_id": "C5137444", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of exonucleolytic catabolism of deadenylated mRNA", "definition": "Any process that activates or increases the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay. [GOC:vw, PMID:30601114]"}
{"concept_id": "C5137445", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of exonucleolytic catabolism of deadenylated mRNA", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay. [GOC:vw, PMID:30601114]"}
{"concept_id": "C5137446", "aliases": ["nuclear membrane-spindle pole body anchor activity", "spindle pole body nuclear membrane anchor activity"], "types": ["T044"], "canonical_name": "spindle pole body-nuclear membrane anchor activity", "definition": "The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body. [GOC:vw, PMID:9763447]"}
{"concept_id": "C5137447", "aliases": [], "types": ["T043"], "canonical_name": "extracellular ATP signaling", "definition": "The series of molecular signals mediated by the detection of extracellular ATP. [GOC:tb, PMID:12948585, PMID:20817461, PMID:29274390]"}
{"concept_id": "C5137448", "aliases": [], "types": ["T026"], "canonical_name": "COPI-coated vesicle lumen", "definition": "The volume enclosed by the membrane of a COPI-coated endocytic vesicle. [GOC:pde, PMID:29535154]"}
{"concept_id": "C5137449", "aliases": [], "types": ["T026"], "canonical_name": "COPII-coated vesicle lumen", "definition": "The volume enclosed by the membrane of a COPII-coated endocytic vesicle. [GOC:pde, PMID:21172817]"}
{"concept_id": "C5137450", "aliases": [], "types": ["T026"], "canonical_name": "phagolysosome vesicle lumen", "definition": "The volume enclosed by the membrane of a phagolysosome. [GOC:pde, PMID:29471269]"}
{"concept_id": "C5137451", "aliases": [], "types": ["T026"], "canonical_name": "phagolysosome vesicle membrane", "definition": "The lipid bylayer surrounding a phagolysosome. [GOC:pde, PMID:29471269]"}
{"concept_id": "C5137452", "aliases": [], "types": ["T026"], "canonical_name": "clathrin-coated endocytic vesicle lumen", "definition": "The volume enclosed by the membrane of a clathrin-coated endocytic vesicle. [GOC:pde, PMID:2516741]"}
{"concept_id": "C5137453", "aliases": [], "types": ["T044"], "canonical_name": "cyclic-GMP-AMP hydrolase activity", "definition": "Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP. [GOC:sp, PMID:25344812, RHEA:58808]"}
{"concept_id": "C5137454", "aliases": ["histone H3 K37 methylation", "histone H3K37me", "histone lysine H3 K37 methylation"], "types": ["T044"], "canonical_name": "histone H3-K37 methylation", "definition": "The modification of histone H3 by addition of one or more methyl groups to lysine at position 37 of the histone. [GOC:mah, PMID:30773398]"}
{"concept_id": "C5137455", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic side of plasma membrane, cell tip", "definition": "The leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:vw, PMID:28292899]"}
{"concept_id": "C5137456", "aliases": ["culmorin anabolism", "culmorin formation", "culmorin synthesis", "culmorin biosynthesis"], "types": ["T044"], "canonical_name": "culmorin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of culmorin, a sesquiterpenoid fungal metabolite and mycotoxin produced by some ascomycete species such as Fusarium culmorum, F. graminearum, F. venenatum and Leptosphaeria oraemaris. [GOC:ach, PMID:19880637, PMID:26673640]"}
{"concept_id": "C5137457", "aliases": [], "types": ["T042"], "canonical_name": "regulation of imaginal disc-derived wing vein specification", "definition": "Any process that modulates the frequency, rate or extent of imaginal disc-derived wing vein specification. [GOC:ha, PMID:11861482]"}
{"concept_id": "C5137458", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of imaginal disc-derived wing vein specification", "definition": "Any process that activates or increases the frequency, rate or extent of imaginal disc-derived wing vein specification. [GOC:ha, PMID:11861482]"}
{"concept_id": "C5137459", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of imaginal disc-derived wing vein specification", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived wing vein specification. [GOC:ha, PMID:11861482]"}
{"concept_id": "C5137460", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of animal organ morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. [GOC:kmv]"}
{"concept_id": "C5137461", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of animal organ morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. [GOC:kmv]"}
{"concept_id": "C5137462", "aliases": [], "types": ["T044"], "canonical_name": "regulation of lipid transporter activity", "definition": "Any process that modulates the frequency, rate, or extent of lipid transporter activity. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390]"}
{"concept_id": "C5137463", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of lipid transporter activity", "definition": "Any process that increases the frequency, rate, or extent of lipid transporter activity. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390]"}
{"concept_id": "C5137464", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of lipid transporter activity", "definition": "Any process that decreases the frequency, rate, or extent of lipid transporter activity. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390]"}
{"concept_id": "C5137465", "aliases": [], "types": ["T043"], "canonical_name": "regulation of compound eye photoreceptor cell differentiation", "definition": "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation. [GOC:ha, PMID:16377567]"}
{"concept_id": "C5137466", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of compound eye photoreceptor cell differentiation", "definition": "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation. [GOC:ha, PMID:16377567]"}
{"concept_id": "C5137467", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of compound eye photoreceptor cell differentiation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation. [GOC:ha, PMID:16377567]"}
{"concept_id": "C5137468", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of very-low-density lipoprotein particle clearance", "definition": "Any process that increases the frequency, rate or extent of very-low-density lipoprotein particle clearance. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:25510864]"}
{"concept_id": "C5137469", "aliases": [], "types": ["T043"], "canonical_name": "gamma-tubulin complex localization to nuclear side of mitotic spindle pole body", "definition": "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the nuclear side of the mitotic spindle pole body. [GOC:vw, PMID:19942852]"}
{"concept_id": "C5137470", "aliases": [], "types": ["T043"], "canonical_name": "gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body", "definition": "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the cytoplasmic side of the mitotic spindle pole body. [GOC:vw, PMID:19001497]"}
{"concept_id": "C5137471", "aliases": [], "types": ["T043"], "canonical_name": "myotube cell migration", "definition": "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse. [GOC:ha, PMID:29122742]"}
{"concept_id": "C5137472", "aliases": [], "types": ["T043"], "canonical_name": "regulation of myotube cell migration", "definition": "Any process that modulates the frequency, rate or extent of myotube cell migration. [GOC:ha, PMID:29122742]"}
{"concept_id": "C5137473", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of myotube cell migration", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration. [GOC:ha, PMID:29122742]"}
{"concept_id": "C5137474", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of myotube cell migration", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration. [GOC:ha, PMID:29122742]"}
{"concept_id": "C5137475", "aliases": [], "types": ["T043"], "canonical_name": "phloem loading", "definition": "The process of loading solutes into the sieve tube or companion cell of the phloem for long distance transport from source to sink. [GOC:lr, PMID:19025382]"}
{"concept_id": "C5137476", "aliases": [], "types": ["T043"], "canonical_name": "phloem unloading", "definition": "The process of unloading solutes that are produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues. [GOC:lr, PMID:19025382]"}
{"concept_id": "C5137477", "aliases": [], "types": ["T043"], "canonical_name": "phloem sucrose unloading", "definition": "The process of unloading sucrose that is produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues. [GOC:lr, PMID:30018170]"}
{"concept_id": "C5137478", "aliases": [], "types": ["T044"], "canonical_name": "ribitol-5-phosphatase activity", "definition": "Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate. [GOC:rn, PMID:30240188]"}
{"concept_id": "C5137481", "aliases": [], "types": ["T045"], "canonical_name": "meiotic drive", "definition": "A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis. [GOC:mah, PMID:26920473, PMID:29322557, PMID:29499907]"}
{"concept_id": "C5137482", "aliases": [], "types": ["T044"], "canonical_name": "Norrin signaling pathway", "definition": "The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state. [GOC:BHF, GOC:rl, PMID:15035989, PMID:17955262]"}
{"concept_id": "C5137483", "aliases": [], "types": ["T043"], "canonical_name": "protein-RNA complex remodeling", "definition": "The acquisition, loss, or modification of macromolecules within a protein-RNA complex, resulting in the alteration of an existing complex. [GOC:rn, PMID:19737519, PMID:20542003, PMID:24240281]"}
{"concept_id": "C5137484", "aliases": [], "types": ["T042"], "canonical_name": "regulation of imaginal disc-derived leg joint morphogenesis", "definition": "Any process that modulates the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis, the process in which the anatomical structure of the imaginal disc-derived leg joint is generated and organized. [GOC:ha, PMID:25329825]"}
{"concept_id": "C5137485", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of imaginal disc-derived leg joint morphogenesis", "definition": "Any process that activates or increases the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis. [GOC:ha, PMID:25329825]"}
{"concept_id": "C5137486", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of imaginal disc-derived leg joint morphogenesis", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis. [GOC:ha, PMID:25329825]"}
{"concept_id": "C5137487", "aliases": ["flagellum attachment zone organisation", "FAZ organization"], "types": ["T043"], "canonical_name": "flagellum attachment zone organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum attachment zone. FAZ is a network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species. [GOC:ach, PMID:26776656]"}
{"concept_id": "C5137488", "aliases": [], "types": ["T043"], "canonical_name": "L-glutamate import into mitochondrion", "definition": "The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix. [GOC:vw, PMID:30297026]"}
{"concept_id": "C5137490", "aliases": [], "types": ["T026"], "canonical_name": "magnetosome lumen", "definition": "The volume enclosed by the membrane of a magnetosome. [GOC:aa, PMID:27620945]"}
{"concept_id": "C5137491", "aliases": [], "types": ["T026"], "canonical_name": "magnetosome membrane", "definition": "The lipid bilayer surrounding a magnetosome. [GOC:aa, PMID:27620945]"}
{"concept_id": "C5137492", "aliases": [], "types": ["T043"], "canonical_name": "protein maturation by nickel ion transfer", "definition": "A process that contributes to the delivery of nickel ions to a target protein to facilitate its maturation. [GOC:al, PMID:24115911]"}
{"concept_id": "C5137493", "aliases": ["lipid carrier activity"], "types": ["T044"], "canonical_name": "lipid transfer activity", "definition": "Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C5137494", "aliases": ["phospholipid carrier activity"], "types": ["T044"], "canonical_name": "phospholipid transfer activity", "definition": "Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C5137495", "aliases": [], "types": ["T044"], "canonical_name": "sphingolipid transfer activity", "definition": "Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C5137496", "aliases": ["ceramide carrier activity"], "types": ["T044"], "canonical_name": "ceramide transfer activity", "definition": "Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C5137497", "aliases": ["cholesterol carrier activity"], "types": ["T044"], "canonical_name": "cholesterol transfer activity", "definition": "Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C5137498", "aliases": ["oxysterol carrier activity"], "types": ["T044"], "canonical_name": "oxysterol transfer activity", "definition": "Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]"}
{"concept_id": "C5137499", "aliases": ["sensory detection of cold stimulus during thermoception", "sensory transduction of cold stimulus during thermoception", "thermoception, sensory detection of cold stimulus", "thermoception, sensory transduction of cold stimulus"], "types": ["T040"], "canonical_name": "detection of cold stimulus involved in thermoception", "definition": "The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception. [PMID:21335241]"}
{"concept_id": "C5137500", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of actin filament bundle convergence involved in mitotic contractile ring assembly", "definition": "Any process that activates or increases the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly. [GOC:vw, PMID:24798735]"}
{"concept_id": "C5137501", "aliases": [], "types": ["T043"], "canonical_name": "regulation of actin filament bundle convergence involved in mitotic contractile ring assembly", "definition": "Any process that modulates the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly. [GOC:vw, PMID:24798735]"}
{"concept_id": "C5137502", "aliases": [], "types": ["T044"], "canonical_name": "regulation of torso signaling pathway", "definition": "Any process that modulates the frequency, rate or extent of the torso signaling pathway. [GOC:ha, PMID:23732470]"}
{"concept_id": "C5137503", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of torso signaling pathway", "definition": "Any process that activates or increases the frequency, rate or extent of the torso signaling pathway. [GOC:ha, PMID:23732470]"}
{"concept_id": "C5137504", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of torso signaling pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the torso signaling pathway. [GOC:ha, PMID:23732470]"}
{"concept_id": "C5137505", "aliases": [], "types": ["T044"], "canonical_name": "steroid hormone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:krc, GOC:nln]"}
{"concept_id": "C5137506", "aliases": [], "types": ["T043"], "canonical_name": "adherens junction disassembly", "definition": "The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, PMID:25490267]"}
{"concept_id": "C5137507", "aliases": [], "types": ["T043"], "canonical_name": "cell-substrate junction disassembly", "definition": "The disaggregation of a cell-substrate junction into its constituent components. [GOC:aruk, GOC:bc, PMID:25490267]"}
{"concept_id": "C5137508", "aliases": [], "types": ["T043"], "canonical_name": "focal adhesion disassembly", "definition": "The disaggregation of a focal adhesion into its constituent components. A focal adhesion is a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also functions as a locus of signal transduction activity. [PMID:25490267]"}
{"concept_id": "C5137509", "aliases": [], "types": ["T043"], "canonical_name": "regulation of focal adhesion disassembly", "definition": "Any process that modulates the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components. [PMID:25490267]"}
{"concept_id": "C5137510", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of focal adhesion disassembly", "definition": "Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components. [PMID:25490267]"}
{"concept_id": "C5137511", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of focal adhesion disassembly", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a focal adhesion into its constituent components. [PMID:25490267]"}
{"concept_id": "C5137512", "aliases": ["Mlu1-box binding factor assembly", "MBF complex assembly", "DSC1 transcription factor complex assembly"], "types": ["T043"], "canonical_name": "MBF transcription complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an MBF transcription complex. [PMID:9303312]"}
{"concept_id": "C5137513", "aliases": ["negative regulation of protein localisation to chromatin"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to chromatin", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. [PMID:20889714, PMID:29899453]"}
{"concept_id": "C5137514", "aliases": ["positive regulation of protein localisation to chromatin"], "types": ["T043"], "canonical_name": "positive regulation of protein localization to chromatin", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin. [PMID:20889714, PMID:29899453]"}
{"concept_id": "C5137515", "aliases": [], "types": ["T043"], "canonical_name": "regulation of bile acid secretion", "definition": "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]"}
{"concept_id": "C5137516", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of bile acid secretion", "definition": "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]"}
{"concept_id": "C5137517", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of bile acid secretion", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]"}
{"concept_id": "C5137518", "aliases": ["down regulation of transcription termination from Pol II promoter", "down regulation of termination of RNA polymerase II transcription", "downregulation of termination of RNA polymerase II transcription", "down regulation of RNA 3'-end formation by RNA polymerase II", "down regulation of transcription termination from RNA polymerase II promoter", "down-regulation of transcription termination from Pol II promoter", "down-regulation of RNA polymerase II transcription termination", "downregulation of RNA 3'-end formation by RNA polymerase II", "down regulation of RNA polymerase II transcription termination", "downregulation of transcription termination from Pol II promoter", "down-regulation of transcription termination from RNA polymerase II promoter", "negative regulation of transcription termination from Pol II promoter", "down-regulation of termination of RNA polymerase II transcription", "downregulation of RNA polymerase II transcription termination", "negative regulation of transcription termination from RNA polymerase II promoter", "downregulation of transcription termination from RNA polymerase II promoter", "negative regulation of RNA polymerase II transcription termination", "negative regulation of RNA 3'-end formation by RNA polymerase II", "down-regulation of RNA 3'-end formation by RNA polymerase II"], "types": ["T045"], "canonical_name": "negative regulation of termination of RNA polymerase II transcription", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription. [GOC:krc, GOC:vw, PMID:29899453]"}
{"concept_id": "C5137519", "aliases": ["occluding cell junction assembly", "occluding junction assembly"], "types": ["T043"], "canonical_name": "tight junction assembly", "definition": "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. [GOC:rl]"}
{"concept_id": "C5137520", "aliases": ["occluding cell junction organization", "occluding junction organization"], "types": ["T043"], "canonical_name": "tight junction organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. [GOC:krc, GOC:rl]"}
{"concept_id": "C5137521", "aliases": [], "types": ["T042"], "canonical_name": "regulation of anther dehiscence", "definition": "Any process involved in the dehiscence of an anther to release the pollen grains contained within it. [GOC:lr, PMID:30911018]"}
{"concept_id": "C5137522", "aliases": [], "types": ["T042"], "canonical_name": "positive regulation of anther dehiscence", "definition": "Any process that activates or increases the frequency, rate or extent of anther dehiscence. [GOC:lr, PMID:30911018]"}
{"concept_id": "C5137523", "aliases": [], "types": ["T042"], "canonical_name": "negative regulation of anther dehiscence", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of anther dehiscence. [GOC:lr, PMID:30911018]"}
{"concept_id": "C5137524", "aliases": [], "types": ["T038"], "canonical_name": "positive regulation of imaginal disc-derived wing size", "definition": "Any process that increases the size of an imaginal disc-derived wing. [GOC:ha, PIMD:23485686]"}
{"concept_id": "C5137525", "aliases": [], "types": ["T026"], "canonical_name": "cone photoreceptor outer segment", "definition": "The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins. [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]"}
{"concept_id": "C5137526", "aliases": [], "types": ["T026"], "canonical_name": "rod photoreceptor outer segment", "definition": "The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins. [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]"}
{"concept_id": "C5137527", "aliases": [], "types": ["T026"], "canonical_name": "cone photoreceptor disc membrane", "definition": "Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane. [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]"}
{"concept_id": "C5137528", "aliases": [], "types": ["T026"], "canonical_name": "rod photoreceptor disc membrane", "definition": "Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment. [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]"}
{"concept_id": "C5137529", "aliases": [], "types": ["T026"], "canonical_name": "rod photoreceptor disc lumen", "definition": "The volume enclosed by the membrane of a rod photoreceptor cell disc membrane. [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]"}
{"concept_id": "C5137530", "aliases": [], "types": ["T044"], "canonical_name": "methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity", "definition": "Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2. [PMID:31043749]"}
{"concept_id": "C5137531", "aliases": [], "types": ["T043"], "canonical_name": "endocytosis, site selection", "definition": "The process of selecting and or marking the position where endocytosis will occur. [GOC:vw, PMID:30044717]"}
{"concept_id": "C5137532", "aliases": [], "types": ["T026"], "canonical_name": "telodendria", "definition": "Telodendria are projections that originate from the axon pedicle and form gap junctions with other neurons. [GOC:cvs, GOC:krc, PMID:11074451, PMID:11506430, PMID:14755521, PMID:1646866, PMID:20533354, PMID:29127712, PMID:451992, PMID:8390352]"}
{"concept_id": "C5137533", "aliases": [], "types": ["T026"], "canonical_name": "cone telodendria", "definition": "Cone telodendria are projections that originate from the cone pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina. [GOC:cvs, GOC:krc, PMID:29127712]"}
{"concept_id": "C5137534", "aliases": [], "types": ["T026"], "canonical_name": "rod telodendria", "definition": "Rod telodendria are projections that originate from the rod pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina. [GOC:cvs, GOC:krc, PMID:14755521]"}
{"concept_id": "C5137535", "aliases": [], "types": ["T043"], "canonical_name": "proacrosomal vesicle fusion", "definition": "Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome. [GOC:krc, PMID:29991750]"}
{"concept_id": "C5137536", "aliases": ["GTF activity", "basal transcription factor activity", "general transcription factor activity"], "types": ["T044"], "canonical_name": "general transcription initiation factor activity", "definition": "A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. [GOC:txnOH-2018]"}
{"concept_id": "C5137537", "aliases": [], "types": ["T044"], "canonical_name": "RNA topoisomerase activity", "definition": "Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA. [GOC:lnp, PMID:23912945, PMID:27257063]"}
{"concept_id": "C5137538", "aliases": ["5-hydroxytryptamine-gated cation-selective signalling pathway", "5-HT-gated cation-selective signaling pathway", "5-hydroxytryptamine-gated cation-selective signaling pathway", "5-HT-gated cation-selective signalling pathway", "serotonin-gated cation-selective signalling pathway"], "types": ["T044"], "canonical_name": "serotonin-gated cation-selective signaling pathway", "definition": "The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. [GOC:bhm, PMID:25392484, PMID:27764665]"}
{"concept_id": "C5137539", "aliases": [], "types": ["T043"], "canonical_name": "anterograde axonal transport of neurotransmitter receptor complex", "definition": "The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons. [PMID:28680963]"}
{"concept_id": "C5137540", "aliases": ["intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential"], "types": ["T044"], "canonical_name": "intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential", "definition": "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential. [PMID:21358644]"}
{"concept_id": "C5137541", "aliases": ["intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential"], "types": ["T044"], "canonical_name": "intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential", "definition": "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential. [GOC:pvn]"}
{"concept_id": "C5137542", "aliases": [], "types": ["T044"], "canonical_name": "RNA polyadenylation at postsynapse", "definition": "A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse. [PMID:22727665]"}
{"concept_id": "C5137543", "aliases": [], "types": ["T044"], "canonical_name": "translation at presynapse", "definition": "Translation that occurs at the presynapse. [PMID:27321671]"}
{"concept_id": "C5137544", "aliases": [], "types": ["T045"], "canonical_name": "translation at presynapse, modulating chemical synaptic transmission", "definition": "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. [PMID:27321671]"}
{"concept_id": "C5137545", "aliases": [], "types": ["T043"], "canonical_name": "presynaptic endocytosis", "definition": "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. [PMID:24719103]"}
{"concept_id": "C5137546", "aliases": [], "types": ["T043"], "canonical_name": "postsynaptic endocytosis", "definition": "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. [PMID:12839988]"}
{"concept_id": "C5137547", "aliases": ["perforant pathway to DG granule cell synapse"], "types": ["T030"], "canonical_name": "perforant pathway to dendrate granule cell synapse", "definition": "A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus. [PMID:22727665, PMID:29199135]"}
{"concept_id": "C5137548", "aliases": [], "types": ["T044"], "canonical_name": "translation at synapse", "definition": "Translation that occurs at the synapse. [PMID:23083742]"}
{"concept_id": "C5137549", "aliases": [], "types": ["T045"], "canonical_name": "translation at postsynapse", "definition": "Translation that occurs at the postsynapse. [PMID:20427644]"}
{"concept_id": "C5137550", "aliases": [], "types": ["T045"], "canonical_name": "regulation of translation at synapse", "definition": "Any process that regulates translation occurring at the synapse. [PMID:20427644]"}
{"concept_id": "C5137551", "aliases": [], "types": ["T045"], "canonical_name": "regulation of translation at presynapse", "definition": "Any process that regulates translation occurring at the presynapse. [PMID:20427644]"}
{"concept_id": "C5137552", "aliases": [], "types": ["T045"], "canonical_name": "regulation of translation at postsynapse", "definition": "Any process that regulates translation occurring at the postsynapse. [PMID:20427644]"}
{"concept_id": "C5137553", "aliases": [], "types": ["T044"], "canonical_name": "protein catabolic process at synapse", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. [PMID:17062563]"}
{"concept_id": "C5137554", "aliases": [], "types": ["T044"], "canonical_name": "protein catabolic process at presynapse", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. [PMID:27764673]"}
{"concept_id": "C5137555", "aliases": [], "types": ["T044"], "canonical_name": "protein catabolic process at postsynapse", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. [PMID:17062563]"}
{"concept_id": "C5137556", "aliases": [], "types": ["T044"], "canonical_name": "regulation protein catabolic process at synapse", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. [PMID:23083742]"}
{"concept_id": "C5137557", "aliases": [], "types": ["T044"], "canonical_name": "regulation protein catabolic process at presynapse", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. [PMID:27764673]"}
{"concept_id": "C5137558", "aliases": [], "types": ["T044"], "canonical_name": "regulation protein catabolic process at postsynapse", "definition": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. [PMID:17062563]"}
{"concept_id": "C5137559", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cellular response to phosphate starvation", "definition": "Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation. [PMID:29414789]"}
{"concept_id": "C5137560", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cellular response to phosphate starvation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to phosphate starvation. [PMID:29414789]"}
{"concept_id": "C5137561", "aliases": [], "types": ["T044"], "canonical_name": "PRC1 complex binding", "definition": "Binding to a PRC1 complex. [PMID:15280237]"}
{"concept_id": "C5137562", "aliases": [], "types": ["T044"], "canonical_name": "mitochondrial proton-transporting ATP synthase complex binding", "definition": "Binding to a mitochondrial proton-transporting ATP synthase complex. [PMID:12110673]"}
{"concept_id": "C5137563", "aliases": [], "types": ["T044"], "canonical_name": "mRNA cap binding complex binding", "definition": "Binding to a mRNA cap binding complex. [PMID:16938833]"}
{"concept_id": "C5137564", "aliases": [], "types": ["T026"], "canonical_name": "Woronin body", "definition": "Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes. [PMID:12640443, PMID:15155882, PMID:18227279, PMID:20707002, PMID:23882222]"}
{"concept_id": "C5137565", "aliases": [], "types": ["T043"], "canonical_name": "viral entry via permeabilization of host membrane", "definition": "The entry of a virus into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration capsid protein. Results in release of the virus contents into the host cell cytoplasm. [PMID:20427561, PMID:25055856]"}
{"concept_id": "C5137566", "aliases": ["ER-plasma membrane contact site", "ER-PM contact site", "endoplasmic reticulum-plasma membrane contact junction", "EPCS"], "types": ["T026"], "canonical_name": "endoplasmic reticulum-plasma membrane contact site", "definition": "A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes. [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]"}
{"concept_id": "C5137567", "aliases": [], "types": ["T043"], "canonical_name": "gluconate import across plasma membrane", "definition": "The directed movement of gluconate from outside of a cell, across the plasma membrane and into the cytosol. [PMID:10735857]"}
{"concept_id": "C5137568", "aliases": [], "types": ["T043"], "canonical_name": "hexose import across plasma membrane", "definition": "The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol. [PMID:10735857]"}
{"concept_id": "C5137569", "aliases": [], "types": ["T044"], "canonical_name": "exogenous protein binding", "definition": "Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein. [PMID:28861068]"}
{"concept_id": "C5137570", "aliases": ["correction of mitotic kinetochore microtubule attachment defects", "repair of mitotic kinetochore microtubule attachment defects"], "types": ["T043"], "canonical_name": "repair of mitotic kinetochore microtubule attachment defect", "definition": "The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected. [PMID:15525536]"}
{"concept_id": "C5137571", "aliases": ["correction of kinetochore microtubule attachment defects", "repair of kinetochore microtubule attachment defects"], "types": ["T043"], "canonical_name": "repair of kinetochore microtubule attachment defect", "definition": "The cell cycle process where kinetochore microtubule attachment defects are corrected. [PMID:15525536]"}
{"concept_id": "C5137572", "aliases": ["regulation of division septum formation involved in mitotic cell cycle", "regulation of formation of division septum involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "regulation of mitotic division septum assembly", "definition": "Any process that modulates the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. [PMID:22786806]"}
{"concept_id": "C5137573", "aliases": ["L-glutamate--lipid II transaminase activity", "undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity"], "types": ["T044"], "canonical_name": "carbon-nitrogen ligase activity on lipid II", "definition": "Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate. [PMID:22291598, PMID:30093673, PMID:30154570, RHEA:57928]"}
{"concept_id": "C5137574", "aliases": ["ER-endosome membrane contact site"], "types": ["T026"], "canonical_name": "endoplasmic reticulum-endosome membrane contact site", "definition": "A contact site between the endoplasmic reticulum membrane and the endosome membrane. [PMID:24105263, PMID:30220460]"}
{"concept_id": "C5137575", "aliases": [], "types": ["T043"], "canonical_name": "endosome fission", "definition": "The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. [PMID:25416943, PMID:30220460]"}
{"concept_id": "C5137576", "aliases": [], "types": ["T044"], "canonical_name": "protein mono-ADP-ribosylation", "definition": "The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids. [PMID:25043379]"}
{"concept_id": "C5137577", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-serine ADP-deribosylation", "definition": "The removal of ADP-ribose from ADP-ribosylserine. [PMID:28650317, PMID:29234005]"}
{"concept_id": "C5137578", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-glutamate ADP-deribosylation", "definition": "The removal of ADP-ribose from ADP-ribosylglutamate. [PMID:23481255]"}
{"concept_id": "C5137579", "aliases": [], "types": ["T044"], "canonical_name": "ADP-ribosylserine hydrolase activity", "definition": "Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose. [PMID:28650317, PMID:29234005]"}
{"concept_id": "C5137580", "aliases": [], "types": ["T044"], "canonical_name": "ADP-ribosylglutamate hydrolase activity", "definition": "Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose. [PMID:23481255]"}
{"concept_id": "C5137581", "aliases": [], "types": ["T044"], "canonical_name": "pathogen-derived receptor ligand activity", "definition": "The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity. [PMID:20601497]"}
{"concept_id": "C5137582", "aliases": [], "types": ["T045"], "canonical_name": "general transcription initiation factor binding", "definition": "Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation. [GOC:txnOH-2018]"}
{"concept_id": "C5137583", "aliases": [], "types": ["T045"], "canonical_name": "DNA-binding transcription factor binding", "definition": "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]"}
{"concept_id": "C5137584", "aliases": ["iron import into cell by endocytosis"], "types": ["T043"], "canonical_name": "endocytic iron import into cell", "definition": "Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis. [PMID:23092063]"}
{"concept_id": "C5137585", "aliases": ["small molecular sensor activity", "small molecule sensing activity"], "types": ["T044"], "canonical_name": "small molecule sensor activity", "definition": "Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule. [PMID:26328879]"}
{"concept_id": "C5137586", "aliases": [], "types": ["T043"], "canonical_name": "serine import into mitochondrion", "definition": "The process in which serine is transported from the cytosol into the mitochondrial matrix. [PMID:30442778]"}
{"concept_id": "C5137587", "aliases": [], "types": ["T043"], "canonical_name": "pollen-stigma interaction", "definition": "The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae. [PMID:27899537]"}
{"concept_id": "C5137588", "aliases": [], "types": ["T043"], "canonical_name": "pollen-style interaction", "definition": "The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte. [PMID:27899537]"}
{"concept_id": "C5137589", "aliases": [], "types": ["T044"], "canonical_name": "intramembrane lipid transporter activity", "definition": "Enables the transport of a lipid from a region of a membrane to a different region on the same membrane. [PMID:16828084]"}
{"concept_id": "C5137590", "aliases": [], "types": ["T044"], "canonical_name": "lipoprotein releasing activity", "definition": "The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex. [PMID:10783239, PMID:21670534]"}
{"concept_id": "C5137591", "aliases": [], "types": ["T044"], "canonical_name": "protein sequestering activity", "definition": "Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:1493333]"}
{"concept_id": "C5137592", "aliases": [], "types": ["T044"], "canonical_name": "cargo adaptor activity", "definition": "Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery. [PMID:25795254]"}
{"concept_id": "C5137593", "aliases": [], "types": ["T044"], "canonical_name": "molecular sequestering activity", "definition": "Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:13130076]"}
{"concept_id": "C5137594", "aliases": [], "types": ["T044"], "canonical_name": "calcium ion sequestering activity", "definition": "Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:13130076]"}
{"concept_id": "C5137595", "aliases": [], "types": ["T044"], "canonical_name": "iron ion sequestering activity", "definition": "Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:27780864]"}
{"concept_id": "C5137596", "aliases": [], "types": ["T043"], "canonical_name": "export across cell outer membrane", "definition": "The directed movement of a substance across the outer membrane in cells with two membranes. [PMID:15968039]"}
{"concept_id": "C5137597", "aliases": [], "types": ["T044"], "canonical_name": "protein transporter activity", "definition": "Directly binding to a specific protein and delivering it to a specific cellular location. [PMID:18706423]"}
{"concept_id": "C5137598", "aliases": ["decoy receptor"], "types": ["T044"], "canonical_name": "receptor decoy activity", "definition": "Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor. [Wikipedia:Decoy_receptors]"}
{"concept_id": "C5137599", "aliases": ["pathogen-associated molecular pattern receptor decoy activity", "pattern recognition receptor decoy activity"], "types": ["T044"], "canonical_name": "PAMP receptor decoy activity", "definition": "Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response. [PMID:20724636]"}
{"concept_id": "C5137600", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation by symbiont of host autophagy", "definition": "Any process in which a symbiont organism decreases the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pg]"}
{"concept_id": "C5137601", "aliases": [], "types": ["T044"], "canonical_name": "solute:anion antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(in) + solute(out) = anion(out) + solute(in). [GOC:pg]"}
{"concept_id": "C5137602", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of protein localization to medial cortex", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex. [PMID:30853434]"}
{"concept_id": "C5137603", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled intramembrane lipid transporter activity", "definition": "Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases. [PMID:16828084]"}
{"concept_id": "C5137604", "aliases": ["floppase activity (cytosolic to exoplasmic leaftlet)"], "types": ["T044"], "canonical_name": "floppase activity", "definition": "Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:20043909, PMID:25284293, Wikipedia:Flippase]"}
{"concept_id": "C5137605", "aliases": [], "types": ["T043"], "canonical_name": "lysophospholipid translocation", "definition": "The movement of a lysophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. [PMID:15661733]"}
{"concept_id": "C5137606", "aliases": [], "types": ["T043"], "canonical_name": "xenobiotic detoxification by transmembrane export across the cell outer membrane", "definition": "A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane. [PMID:11948170]"}
{"concept_id": "C5137607", "aliases": [], "types": ["T044"], "canonical_name": "aminophospholipid translocation", "definition": "The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. [GOC:pg]"}
{"concept_id": "C5137608", "aliases": ["intermembrane lipopolysaccharide transfer activity", "lipopolysaccharide carrier activity", "intermembrane LPS transporter activity", "intermembrane lipopolysaccharide transporter activity"], "types": ["T044"], "canonical_name": "lipopolysaccharide transfer activity", "definition": "Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. [PMID:24639492]"}
{"concept_id": "C5137609", "aliases": ["glycerophospholipid flippase activity (exoplasmic to cytosolic leaftlet)"], "types": ["T044"], "canonical_name": "glycerophospholipid flippase activity", "definition": "Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:26212235]"}
{"concept_id": "C5137610", "aliases": ["LPS localization to cell outer membrane"], "types": ["T043"], "canonical_name": "lipopolysaccharide localization to cell outer membrane", "definition": "A process in which a lipopolysaccharide is transported to the cell outer membrane. [PMID:24639492]"}
{"concept_id": "C5137611", "aliases": ["diacylglyceride carrier activity"], "types": ["T044"], "canonical_name": "diacylglyceride transfer activity", "definition": "Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location. [PMID:9132017]"}
{"concept_id": "C5137612", "aliases": ["sphingomyelin carrier activity"], "types": ["T044"], "canonical_name": "sphingomyelin transfer activity", "definition": "Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. [PMID:9132017]"}
{"concept_id": "C5137613", "aliases": ["phosphatidylglycerol carrier activity"], "types": ["T044"], "canonical_name": "phosphatidylglycerol transfer activity", "definition": "Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location. [PMID:9132017]"}
{"concept_id": "C5137614", "aliases": ["cerebroside carrier activity"], "types": ["T044"], "canonical_name": "cerebroside transfer activity", "definition": "Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location. [PMID:9132017]"}
{"concept_id": "C5137615", "aliases": ["phosphatidylethanolamine floppase activity (cytosolic to exoplasmic leaftlet)"], "types": ["T044"], "canonical_name": "phosphatidylethanolamine floppase activity", "definition": "Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:10029989]"}
{"concept_id": "C5137616", "aliases": [], "types": ["T044"], "canonical_name": "phosphatidylserine transfer activity", "definition": "Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. [PMID:26206935]"}
{"concept_id": "C5137617", "aliases": ["triglyceride carrier activity"], "types": ["T044"], "canonical_name": "triglyceride transfer activity", "definition": "Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location. [PMID:23475612]"}
{"concept_id": "C5137618", "aliases": ["phosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet)"], "types": ["T044"], "canonical_name": "phosphatidylcholine flippase activity", "definition": "Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:11870854]"}
{"concept_id": "C5137619", "aliases": ["phosphatidylserine flippase activity (exoplasmic to cytosolic leaftlet)"], "types": ["T044"], "canonical_name": "phosphatidylserine flippase activity", "definition": "Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:11870854]"}
{"concept_id": "C5137620", "aliases": ["N-retinylidene-phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)"], "types": ["T044"], "canonical_name": "N-retinylidene-phosphatidylethanolamine flippase activity", "definition": "Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:10412977]"}
{"concept_id": "C5137621", "aliases": ["lysophosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet)"], "types": ["T044"], "canonical_name": "lysophosphatidylcholine flippase activity", "definition": "Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:26945070]"}
{"concept_id": "C5137622", "aliases": ["glycoceramide flippase activity", "glycosylceramide flippase activity (exoplasmic to cytosolic leaftlet)"], "types": ["T044"], "canonical_name": "glycosylceramide flippase activity", "definition": "Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar. [PMID:30530492]"}
{"concept_id": "C5137623", "aliases": [], "types": ["T043"], "canonical_name": "lipid export from cell", "definition": "The directed movement of a lipid from a cell, into the extracellular region. [GOC:pg]"}
{"concept_id": "C5137624", "aliases": [], "types": ["T043"], "canonical_name": "heme export from vacuole to cytoplasm", "definition": "The directed movement of heme from inside the vacuole across the vacuolar membrane and into the cytosol. [PMID:28193844]"}
{"concept_id": "C5137625", "aliases": ["AMY1 signaling pathway"], "types": ["T044"], "canonical_name": "amylin receptor 1 signaling pathway", "definition": "The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 1 (AMY1), a G protein-coupled receptor complex, on the surface of the target cell. Other ligands that have been shown to initiate the AMY1 signaling pathway include the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM). [GOC:aruk, GOC:bc, PMID:22500019]"}
{"concept_id": "C5137626", "aliases": ["AMY2 signaling pathway"], "types": ["T044"], "canonical_name": "amylin receptor 2 signaling pathway", "definition": "The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 2 (AMY2), a G protein-coupled receptor complex, on the surface of the target cell. The AMY2 signaling pathway can also be initiated by adrenomedullin (AM/ADM). [GOC:aruk, GOC:bc, PMID:22500019]"}
{"concept_id": "C5137627", "aliases": ["AMY3 signaling pathway"], "types": ["T044"], "canonical_name": "amylin receptor 3 signaling pathway", "definition": "The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 3 (AMY3), a G protein-coupled receptor complex, on the surface of the target cell. The AMY3 signaling pathway can also be initiated by the amyloid-beta complex. AMY3 signaling results in increased import of calcium ions into the cytosol across plasma membrane, increased phosphorylation of ERK1/2, Act, and a PKA regulatory subunit II, as well as increased expression of cFos. [GOC:aruk, GOC:bc, PMID:22500019]"}
{"concept_id": "C5137628", "aliases": ["complement-dependent synapse pruning"], "types": ["T043"], "canonical_name": "complement-mediated synapse pruning", "definition": "Synaptic pruning mediated by complement system signalling. [GOC:aruk, GOC:bc, PMID:18083105, PMID:22632727, PMID:29844190]"}
{"concept_id": "C5137629", "aliases": ["vertebrate eye-specific segregation"], "types": ["T042"], "canonical_name": "vertebrate eye-specific patterning", "definition": "Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus. [GOC:aruk, GOC:bc, PMID:16025107, PMID:22632727, PMID:29322522]"}
{"concept_id": "C5137630", "aliases": [], "types": ["T044"], "canonical_name": "regulation of deacetylase activity", "definition": "Any process that modulates the frequency, rate or extent of deacetylase activity. [GOC:aruk, GOC:bc, PMID:19457097]"}
{"concept_id": "C5137631", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of deacetylase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of deacetylase activity. [GOC:aruk, GOC:bc, PMID:19457097]"}
{"concept_id": "C5137632", "aliases": [], "types": ["T044"], "canonical_name": "regulation of tubulin deacetylase activity", "definition": "Any process that modulates the frequency, rate or extent of tubulin deacetylase activity. [GOC:aruk, GOC:bc, PMID:19457097]"}
{"concept_id": "C5137633", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of tubulin deacetylase activity", "definition": "Any process that activates or increases the frequency, rate or extent of tubulin deacetylase activity. [GOC:aruk, GOC:bc]"}
{"concept_id": "C5137634", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of tubulin deacetylase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylase activity. [GOC:aruk, GOC:bc, PMID:19457097]"}
{"concept_id": "C5137635", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of arginase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of arginase activity. [GOC:aruk, GOC:bc]"}
{"concept_id": "C5137636", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of arginase activity", "definition": "Any process that activates or increases the frequency, rate or extent of arginase activity. [GOC:aruk, GOC:bc, PMID:26670206]"}
{"concept_id": "C5137637", "aliases": [], "types": ["T044"], "canonical_name": "regulation of protein-glutamine gamma-glutamyltransferase activity", "definition": "Any process that modulates the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity. [GOC:aruk, GOC:bc, PMID:26670206]"}
{"concept_id": "C5137638", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of protein-glutamine gamma-glutamyltransferase activity", "definition": "Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity. [GOC:aruk, GOC:bc, PMID:26670206]"}
{"concept_id": "C5137639", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of protein-glutamine gamma-glutamyltransferase activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity. [GOC:aruk, GOC:bc]"}
{"concept_id": "C5137640", "aliases": ["nervous tissue inflammatory response", "neural tissue inflammatory response", "nerve tissue inflammatory response"], "types": ["T046"], "canonical_name": "neuroinflammatory response", "definition": "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents. [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]"}
{"concept_id": "C5137641", "aliases": [], "types": ["T046"], "canonical_name": "regulation of neuroinflammatory response", "definition": "Any process that modulates the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]"}
{"concept_id": "C5137642", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of neuroinflammatory response", "definition": "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc]"}
{"concept_id": "C5137643", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of neuroinflammatory response", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423]"}
{"concept_id": "C5137644", "aliases": ["multisynaptic bouton", "multi-synaptic bouton", "multi-synapse bouton", "multisynapse bouton", "MSB", "multiple-synapse bouton", "multiple spine synapse bouton"], "types": ["T026"], "canonical_name": "multiple synapse bouton", "definition": "A single axon terminal bouton making contact onto two or more dendritic spines protruding either from a single dendrite or from multiple dendrites. [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:11466428, PMID:18501438, PMID:22028887, PMID:29774619, PMID:7482800, PMID:8366344]"}
{"concept_id": "C5137645", "aliases": ["type 1 multi-synaptic bouton", "MSB1", "type 1 multi-synapse bouton", "type 1 multiple spine synapse bouton", "type 1 multiple-synapse bouton", "type 1 multisynapse bouton", "type 1 multisynaptic bouton"], "types": ["T026"], "canonical_name": "multiple synapse bouton, contacting single dendrite", "definition": "A single axon terminal bouton making contact onto two or more dendritic spines protruding from the same dendrite. [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234]"}
{"concept_id": "C5137646", "aliases": ["type 2 multisynaptic bouton", "MSB2", "type 2 multi-synapse bouton", "type 2 multi-synaptic bouton", "type 2 multisynapse bouton", "type 2 multiple-synapse bouton", "type 2 multiple spine synapse bouton"], "types": ["T026"], "canonical_name": "multiple synapse bouton, contacting multiple dendrites", "definition": "A single axon terminal bouton making contact onto two or more dendritic spines protruding from multiple dendrites. [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234, PMID:7482800, PMID:8366344]"}
{"concept_id": "C5137647", "aliases": ["multiple spine synapse organisation"], "types": ["T043"], "canonical_name": "multiple spine synapse organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and one or more dendritic spines. [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:11466428, PMID:18501438, PMID:22028887, PMID:29774619, PMID:7482800, PMID:8366344]"}
{"concept_id": "C5137648", "aliases": [], "types": ["T043"], "canonical_name": "multiple spine synapse organization, single dendrite", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and a single dendrite. [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234]"}
{"concept_id": "C5137649", "aliases": [], "types": ["T043"], "canonical_name": "multiple spine synapse organization, multiple dendrites", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and two or more dendritic spines protruding either from a single dendrite or from multiple dendrites. [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234, PMID:7482800, PMID:8366344]"}
{"concept_id": "C5137650", "aliases": [], "types": ["T042"], "canonical_name": "regulation of synaptic scaling", "definition": "A process that modulates synaptic scaling. Synaptic scaling is a form of synaptic plasticity, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the electrical activity of the cell. [GOC:aruk, GOC:bc, PMID:14630218, PMID:14735113, PMID:16547515]"}
{"concept_id": "C5137651", "aliases": [], "types": ["T043"], "canonical_name": "amyloid-beta clearance by transcytosis", "definition": "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:26005850]"}
{"concept_id": "C5137652", "aliases": [], "types": ["T043"], "canonical_name": "amyloid-beta clearance by cellular catabolic process", "definition": "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation. [GOC:aruk, GOC:bc, PMID:18289866]"}
{"concept_id": "C5137653", "aliases": ["glia-neurone signaling", "glia-neuron signaling", "glial cell- neuron signalling", "glial cell-neurone signalling", "glia-neurone signalling", "glial cell-neurone singaling", "glia-neuron signalling"], "types": ["T043"], "canonical_name": "glial cell-neuron signaling", "definition": "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signalling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum. [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440]"}
{"concept_id": "C5137654", "aliases": ["neuron-glia signaling", "neurone-glia signalling", "neuron-glial cell signalling", "neurone-glial cell signaling", "neurone-glial cell signalling", "neurone-glia signaling", "neuron-glia signalling"], "types": ["T043"], "canonical_name": "neuron-glial cell signaling", "definition": "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signalling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368]"}
{"concept_id": "C5137656", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microtubule anchoring at centrosome", "definition": "Any process that modulates the frequency, rate or extent of microtubule anchoring at centrosome. [GOC:aruk, GOC:bc, PMID:17139249]"}
{"concept_id": "C5137657", "aliases": ["repression of monocyte activation"], "types": ["T043"], "canonical_name": "negative regulation of monocyte activation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation. [GOC:aruk, PMID:15597323]"}
{"concept_id": "C5137658", "aliases": [], "types": ["T045"], "canonical_name": "regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter", "definition": "A regulation of transcription from RNA polymerase II promoter that results in regulation of iron ion import. [GOC:mah, GOC:TermGenie, PMID:18622392]"}
{"concept_id": "C5137659", "aliases": ["ceramide 1-phosphate carrier activity"], "types": ["T044"], "canonical_name": "ceramide 1-phosphate transfer activity", "definition": "Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:TermGenie, PMID:23863933]"}
{"concept_id": "C5137660", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of potassium ion import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion import across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]"}
{"concept_id": "C5137661", "aliases": [], "types": ["T043"], "canonical_name": "iron ion export across plasma membrane", "definition": "The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region. [GO_REF:0000074, GOC:BHF, GOC:kom, GOC:rl, GOC:TermGenie, PMID:15514116]"}
{"concept_id": "C5137662", "aliases": [], "types": ["T043"], "canonical_name": "regulation of iron export across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region. [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]"}
{"concept_id": "C5137663", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of iron export across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region. [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]"}
{"concept_id": "C5137664", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of iron export across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region. [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]"}
{"concept_id": "C5137665", "aliases": ["phosphatidylethanolamine carrier activity"], "types": ["T044"], "canonical_name": "phosphatidylethanolamine transfer activity", "definition": "Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GO_REF:0000066, GOC:TermGenie, PMID:8606365]"}
{"concept_id": "C5137666", "aliases": [], "types": ["T043"], "canonical_name": "regulation of iron ion import across plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]"}
{"concept_id": "C5137667", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of iron ion import across plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]"}
{"concept_id": "C5137668", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of iron ion import across plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]"}
{"concept_id": "C5137669", "aliases": [], "types": ["T043"], "canonical_name": "regulation of xenobiotic detoxification by transmembrane export across the plasma membrane", "definition": "Any process that modulates the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:15198509]"}
{"concept_id": "C5137670", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:15198509]"}
{"concept_id": "C5137671", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of xenobiotic detoxification by transmembrane export across the plasma membrane", "definition": "Any process that activates or increases the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:15198509]"}
{"concept_id": "C5137672", "aliases": ["intermembrane PA transfer activity", "phosphatidic acid carrier activity"], "types": ["T044"], "canonical_name": "phosphatidic acid transfer activity", "definition": "Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3. [PMID:23042293]"}
{"concept_id": "C5137673", "aliases": [], "types": ["T043"], "canonical_name": "xenobiotic detoxification by transmembrane export across the plasma membrane", "definition": "A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. [PMID:28355133]"}
{"concept_id": "C5137674", "aliases": [], "types": ["T043"], "canonical_name": "xenobiotic transport across blood-brain barrier", "definition": "The directed movement of a xenobiotic through the blood-brain barrier. [PMID:25053619]"}
{"concept_id": "C5137675", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of septum digestion after cytokinesis", "definition": "Any process that activates or increases the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. [GOC:mtg_cell_cycle, GOC:obol]"}
{"concept_id": "C5137676", "aliases": [], "types": ["T043"], "definition": "The selective autophagy process in which a damaged lysosome is degraded by macroautophagy. [PMID:28743755]", "canonical_name": "lysophagy"}
{"concept_id": "C5137677", "aliases": ["glycolipid floppase activity (cytosolic to exoplasmic leaftlet)"], "types": ["T044"], "canonical_name": "glycolipid floppase activity", "definition": "Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [GOC:krc, PMID:11807558]"}
{"concept_id": "C5137678", "aliases": [], "types": ["T043"], "canonical_name": "lipid import into cell", "definition": "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. [GOC:pg]"}
{"concept_id": "C5137679", "aliases": [], "types": ["T044"], "canonical_name": "regulation of arginase activity", "definition": "Any process that modulates the frequency, rate or extent of arginase activity. [GOC:aruk, GOC:bc, PMID:26670206]"}
{"concept_id": "C5137680", "aliases": ["transport across BBB", "transport across blood brain barrier"], "types": ["T043"], "canonical_name": "transport across blood-brain barrier", "definition": "The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]"}
{"concept_id": "C5137681", "aliases": ["up-regulation of formation of division septum involved in mitotic cell cycle", "up-regulation of division septum formation involved in mitotic cell cycle", "up regulation of formation of division septum involved in mitotic cell cycle", "up-regulation of septin assembly and septum formation involved in mitotic cell cycle", "upregulation of septin assembly and septum formation involved in mitotic cell cycle", "upregulation of division septum formation involved in mitotic cell cycle", "up-regulation of mitotic division septum assembly", "upregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle", "upregulation of formation of division septum involved in mitotic cell cycle", "up regulation of division septum formation involved in mitotic cell cycle", "up regulation of mitotic division septum assembly", "up-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle", "up regulation of septin assembly and septum formation involved in mitotic cell cycle"], "types": ["T043"], "canonical_name": "up regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle"}
{"concept_id": "C5201110", "aliases": ["epithelial cell differentiation from mesenchymal cell", "mesenchymal-epithelial transition"], "types": ["T043"], "canonical_name": "mesenchymal to epithelial transition", "definition": "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C5201127", "aliases": [], "types": ["T044"], "definition": "The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. [GOC:dph, GOC:sart]", "canonical_name": "innervation"}
{"concept_id": "C5235022", "aliases": ["2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity", "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity"], "types": ["T044"], "canonical_name": "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "definition": "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. [EC:1.17.4.1]"}
{"concept_id": "C5239882", "aliases": [], "types": ["T043"], "canonical_name": "eupodium"}
{"concept_id": "C5239889", "aliases": ["PAC", "protein aggregate centre"], "types": ["T026"], "definition": "Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. [PMID:32075773]", "canonical_name": "protein aggregate center"}
{"concept_id": "C5239904", "aliases": [], "types": ["T044"], "canonical_name": "limit dextrinase"}
{"concept_id": "C5240332", "aliases": [], "types": ["T026"], "canonical_name": "osteoclastogenesis inhibitory factor"}
{"concept_id": "C5240857", "aliases": ["contractile vacuole complex", "contractile vacuole complex location"], "types": ["T026"], "definition": "A non-membrane-bounded organelle of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally. One of its functions is osmoregulatory. [PMID:23890380]", "canonical_name": "CVC"}
{"concept_id": "C5241293", "aliases": ["P-type transmembrane transporter activity", "P-type ATPase"], "types": ["T044"], "definition": "Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. [PMID:18075584, PMID:25918123]", "canonical_name": "E1-E2 ATPase"}
{"concept_id": "C5241415", "aliases": ["head-tail coupling apparatus", "HTCA"], "types": ["T026"], "definition": "A centrosome-based structure consisting of two cylindrical microtubule-based centrioles and associated components which anchors the flagellum to the sperm head. [GOC:krc, PMID:24415959, PMID:30032984]", "canonical_name": "sperm head-tail coupling apparatus"}
{"concept_id": "C5241416", "aliases": [], "types": ["T026"], "canonical_name": "mu-calpain"}
{"concept_id": "C5241435", "aliases": ["negative regulation of mineralisation", "negative regulation of biomineralisation", "negative regulation of biomineralization"], "types": ["T039"], "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. [PMID:22992051]", "canonical_name": "negative regulation of mineralization"}
{"concept_id": "C5241438", "aliases": [], "types": ["T044"], "canonical_name": "phosphopantetheinyl transferase"}
{"concept_id": "C5379782", "aliases": ["RNA polymerase I transcription regulator complex location"], "types": ["T026"], "canonical_name": "RNA polymerase I transcription regulator complex", "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I. [GOC:mah]"}
{"concept_id": "C5379783", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction"}
{"concept_id": "C5379784", "aliases": [], "types": ["T045"], "canonical_name": "rDNA heterochromatin assembly", "definition": "The assembly of chromatin characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of rDNA. [PMID:10219245]"}
{"concept_id": "C5379785", "aliases": [], "types": ["T026"], "canonical_name": "central bladder"}
{"concept_id": "C5379786", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "definition": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]"}
{"concept_id": "C5379788", "aliases": [], "types": ["T045"], "canonical_name": "cis-regulatory region sequence-specific DNA binding", "definition": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter. [GOC:txnOH-2018]"}
{"concept_id": "C5379789", "aliases": [], "types": ["T045"], "canonical_name": "cis-regulatory region binding"}
{"concept_id": "C5379790", "aliases": [], "types": ["T045"], "canonical_name": "enhancer binding"}
{"concept_id": "C5379792", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase III transcription regulatory region sequence-specific DNA binding", "definition": "Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. [GOC:txnOH, GOC:vw, PMID:12381659]"}
{"concept_id": "C5379793", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I cis-regulatory region sequence-specific DNA binding", "definition": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element). [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]"}
{"concept_id": "C5379794", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase I enhancer sequence-specific DNA binding"}
{"concept_id": "C5379795", "aliases": [], "types": ["T044"], "canonical_name": "G protein-coupled ADP receptor activity", "definition": "Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, GOC:signaling, PMID:11196645]"}
{"concept_id": "C5379796", "aliases": [], "types": ["T044"], "canonical_name": "polysaccharide immune receptor activity", "definition": "Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [PMID:14707091]"}
{"concept_id": "C5379797", "aliases": [], "types": ["T044"], "canonical_name": "intracellular endosomal pattern recognition receptor signaling pathway", "definition": "The series of molecular signals initiated by the binding of a ligand to an intracellular vesicle pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]"}
{"concept_id": "C5379798", "aliases": [], "types": ["T044"], "canonical_name": "stress-activated kinase activity"}
{"concept_id": "C5379799", "aliases": [], "types": ["T044"], "canonical_name": "stress-activated protein kinase activity"}
{"concept_id": "C5379800", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of egg chorion", "definition": "The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster. [GOC:mah, GOC:sensu]"}
{"concept_id": "C5379801", "aliases": ["transcription regulator complex location"], "types": ["T026"], "canonical_name": "transcription regulator complex", "definition": "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl]"}
{"concept_id": "C5379802", "aliases": [], "types": ["T045"], "canonical_name": "DNA methylation-dependent heterochromatin assembly", "definition": "Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. [GOC:mah]"}
{"concept_id": "C5379803", "aliases": ["EOR-mediated activation of NF-kappaB"], "types": ["T044"], "canonical_name": "EOR-mediated NF-kappaB activation"}
{"concept_id": "C5379804", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of NF-kappaB transcription factor activity by EOR"}
{"concept_id": "C5379806", "aliases": [], "types": ["T040"], "canonical_name": "feeding from plant phloem"}
{"concept_id": "C5379807", "aliases": [], "types": ["T040"], "canonical_name": "feeding on blood of other organism"}
{"concept_id": "C5379808", "aliases": [], "types": ["T040"], "canonical_name": "feeding on plant sap"}
{"concept_id": "C5379809", "aliases": [], "types": ["T040"], "canonical_name": "taking of blood meal"}
{"concept_id": "C5379810", "aliases": ["effector-triggered immunity", "innate immune response-activating signal transduction"], "types": ["T040"], "definition": "The series of molecular signals generated as a consequence of a pathogen or microbial effector binding to a plant 'resistance-gene' receptor to activate a plant immune response, usually plant-type hypersensitive response. [GOC:jy, GOC:mah, PMID:11418339, PMID:28105028]", "canonical_name": "effector triggered immunity"}
{"concept_id": "C5379811", "aliases": ["regulation of RNAi-mediated heterochromatin assembly"], "types": ["T045"], "canonical_name": "regulation of heterochromatin assembly by small RNA", "definition": "Any process that modulates the frequency, rate or extent of heterochromatin assembly by small RNA. [GOC:dph, GOC:tb]"}
{"concept_id": "C5379812", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled L-glutamine transmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in). [EC:7.4.2.1]"}
{"concept_id": "C5379813", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled glutamine transmembrane transporter activity"}
{"concept_id": "C5379814", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled D-xylose transmembrane transporter activity"}
{"concept_id": "C5379815", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate anabolism from 2-oxypantoyl lactone"}
{"concept_id": "C5379816", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate biosynthesis from 2-oxypantoyl lactone"}
{"concept_id": "C5379817", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate biosynthesis from valine"}
{"concept_id": "C5379818", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate biosynthetic process from 2-oxypantoyl lactone"}
{"concept_id": "C5379819", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate formation from 2-oxypantoyl lactone"}
{"concept_id": "C5379820", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate formation from valine"}
{"concept_id": "C5379821", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate synthesis from 2-oxypantoyl lactone"}
{"concept_id": "C5379822", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate synthesis from valine"}
{"concept_id": "C5379823", "aliases": [], "types": ["T044"], "canonical_name": "peptidoglycan immune receptor activity", "definition": "Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response. [PMID:14698226]"}
{"concept_id": "C5379824", "aliases": ["perception of parasitic fungus"], "types": ["T040"], "canonical_name": "perception of parasitic fungi"}
{"concept_id": "C5379825", "aliases": [], "types": ["T044"], "canonical_name": "flavonoid 3-hydroxylase"}
{"concept_id": "C5379826", "aliases": [], "types": ["T044"], "canonical_name": "flavonoid 3-monooxygenase"}
{"concept_id": "C5379827", "aliases": [], "types": ["T043"], "canonical_name": "modulation by virus of host anatomical structure or process"}
{"concept_id": "C5379828", "aliases": [], "types": ["T043"], "canonical_name": "modulation by virus of host morphology or physiology"}
{"concept_id": "C5379829", "aliases": ["mitigation of host defenses by virus", "regulation by virus of antiviral response", "mitigation by virus of host immune response", "regulation of defense response to virus by virus", "viral regulation of antiviral response", "regulation of antiviral response by virus", "mitigation of host immune response by virus"], "types": ["T038"], "canonical_name": "mitigation of host antiviral defense response", "definition": "A process by which a virus avoids or tolerates the effects of its host organism's defenses. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. [ISBN:1555811272]"}
{"concept_id": "C5379830", "aliases": [], "types": ["T043"], "canonical_name": "heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein"}
{"concept_id": "C5379831", "aliases": [], "types": ["T044"], "canonical_name": "synaptic receptor adaptor activity", "definition": "The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule. [PMID:10506216]"}
{"concept_id": "C5379832", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of skin epidermis", "definition": "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure. [GOC:mah]"}
{"concept_id": "C5379833", "aliases": [], "types": ["T043"], "canonical_name": "intracellular protein transport in other organism involved in symbiotic interaction"}
{"concept_id": "C5379834", "aliases": [], "types": ["T044"], "canonical_name": "acetyl CoA pathway"}
{"concept_id": "C5379835", "aliases": [], "types": ["T040"], "canonical_name": "mitigation of host defenses by symbiont", "definition": "A process by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C5379836", "aliases": [], "types": ["T040"], "canonical_name": "evasion of other organism defence response"}
{"concept_id": "C5379837", "aliases": [], "types": ["T040"], "canonical_name": "evasion or tolerance of defenses of other organism"}
{"concept_id": "C5379838", "aliases": [], "types": ["T045"], "canonical_name": "heterochromatin formation involved in chromatin silencing by small RNA"}
{"concept_id": "C5379839", "aliases": [], "types": ["T045"], "canonical_name": "small RNA-mediated heterochromatin formation"}
{"concept_id": "C5379840", "aliases": [], "types": ["T045"], "canonical_name": "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region"}
{"concept_id": "C5379841", "aliases": [], "types": ["T045"], "canonical_name": "heterochromatin formation involved in chromatin silencing"}
{"concept_id": "C5379842", "aliases": [], "types": ["T045"], "canonical_name": "heterochromatin formation involved in chromatin silencing at centromere outer repeat region"}
{"concept_id": "C5379843", "aliases": ["chromatin silencing at telomere", "Telomere Position Effect", "heterochromatic silencing at telomere", "subtelomeric silencing", "telomeric silencing", "telomere chromatin silencing"], "types": ["T045"], "canonical_name": "subtelomeric heterochromatin assembly", "definition": "The assembly of chromatin into heterochromatin at the subtelomeric region, resulting in a chromatin conformation refractory to transcription. [GOC:mah, PMID:10219245, PMID:26205977]"}
{"concept_id": "C5379844", "aliases": [], "types": ["T045"], "canonical_name": "establishment of chromatin silencing at telomere"}
{"concept_id": "C5379845", "aliases": [], "types": ["T045"], "canonical_name": "heterochromatic silencing at subtelomere"}
{"concept_id": "C5379846", "aliases": [], "types": ["T045"], "canonical_name": "subtelomere chromatin silencing"}
{"concept_id": "C5379847", "aliases": ["super elongation complex location"], "types": ["T026"], "canonical_name": "super elongation complex", "definition": "A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae. [PMID:17150956, PMID:30102332]"}
{"concept_id": "C5379848", "aliases": ["ELL-EAF-EBP complex location"], "types": ["T026"], "canonical_name": "ELL-EAF-EBP complex"}
{"concept_id": "C5379849", "aliases": [], "types": ["T040"], "canonical_name": "suppression by symbiont of defense-related host reactive oxygen species production"}
{"concept_id": "C5379850", "aliases": [], "types": ["T043"], "canonical_name": "GAAC response"}
{"concept_id": "C5379851", "aliases": [], "types": ["T043"], "canonical_name": "general amino acid control response"}
{"concept_id": "C5379852", "aliases": [], "types": ["T045"], "canonical_name": "DNA negative supercoiling activity", "definition": "Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria. [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:DNA_gyrase]"}
{"concept_id": "C5379853", "aliases": [], "types": ["T044"], "canonical_name": "purinoceptor signaling pathway"}
{"concept_id": "C5379854", "aliases": [], "types": ["T044"], "canonical_name": "signaling scaffold activity"}
{"concept_id": "C5379855", "aliases": [], "types": ["T044"], "canonical_name": "hypoxanthine/xanthine dNTP pyrophosphatase"}
{"concept_id": "C5379856", "aliases": [], "types": ["T044"], "canonical_name": "XTP/dITP diphosphatase"}
{"concept_id": "C5379857", "aliases": [], "types": ["T043"], "canonical_name": "EGFR ligand maturation by peptide bond cleavage"}
{"concept_id": "C5379858", "aliases": ["epidermal growth factor receptor ligand processing"], "types": ["T043"], "canonical_name": "EGFR ligand processing"}
{"concept_id": "C5379859", "aliases": [], "types": ["T044"], "canonical_name": "peptide bond cleavage involved in EGFR ligand maturation"}
{"concept_id": "C5379860", "aliases": [], "types": ["T044"], "canonical_name": "MAMP receptor activity"}
{"concept_id": "C5379861", "aliases": [], "types": ["T044"], "canonical_name": "microbe-associated molecular pattern receptor activity"}
{"concept_id": "C5379862", "aliases": [], "types": ["T044"], "canonical_name": "PAMP receptor activity"}
{"concept_id": "C5379863", "aliases": ["viral exit by cytolysis via suppression of host peptidoglycan biosynthetic process"], "types": ["T043"], "canonical_name": "viral release by cytolysis via suppression of host peptidoglycan biosynthetic process", "definition": "The killing by a virus of host cell by cytolysis, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls. [GOC:bf, GOC:bm, PMID:28894177]"}
{"concept_id": "C5379864", "aliases": [], "types": ["T043"], "canonical_name": "transport of peptides or proteins into other organism during symbiotic interaction"}
{"concept_id": "C5379865", "aliases": [], "types": ["T044"], "canonical_name": "P-P-bond-hydrolysis-driven transporter"}
{"concept_id": "C5379866", "aliases": [], "types": ["T040"], "canonical_name": "active evasion of immune response of other organism involved in symbiotic interaction"}
{"concept_id": "C5379867", "aliases": [], "types": ["T040"], "canonical_name": "mitigation of host immune response"}
{"concept_id": "C5379868", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein-containing complex disassembly", "definition": "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. [GOC:jl]"}
{"concept_id": "C5379869", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein-containing complex assembly", "definition": "Any process that modulates the frequency, rate or extent of protein complex assembly. [GOC:jl]"}
{"concept_id": "C5379870", "aliases": [], "types": ["T044"], "canonical_name": "CTPase activity, coupled"}
{"concept_id": "C5379871", "aliases": ["protein membrane adaptor activity", "protein membrane adaptor"], "types": ["T044"], "canonical_name": "protein-membrane adaptor activity", "definition": "The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle. [GOC:go_curators]"}
{"concept_id": "C5379872", "aliases": [], "types": ["T044"], "canonical_name": "[LysW]-aminoadipate kinase"}
{"concept_id": "C5379873", "aliases": [], "types": ["T044"], "canonical_name": "1-HO-carotenoid methylase"}
{"concept_id": "C5379874", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxycarotenoid methylase"}
{"concept_id": "C5379875", "aliases": [], "types": ["T044"], "canonical_name": "1-hydroxycarotenoid O-methylase"}
{"concept_id": "C5379876", "aliases": [], "types": ["T044"], "canonical_name": "demethylspheroidene O-methyltransferase"}
{"concept_id": "C5379877", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interspecies interactions between organisms"}
{"concept_id": "C5379878", "aliases": [], "types": ["T043"], "canonical_name": "modulation by symbiont of host process", "definition": "The process in which a symbiont organism effects a change in the structure or processes of its host organism. [GOC:cc]"}
{"concept_id": "C5379879", "aliases": [], "types": ["T040"], "canonical_name": "modification by symbiont of host biological process"}
{"concept_id": "C5379880", "aliases": [], "types": ["T040"], "canonical_name": "regulation by symbiont of host system process"}
{"concept_id": "C5379881", "aliases": [], "types": ["T043"], "canonical_name": "bfp-dependent aggregation"}
{"concept_id": "C5379882", "aliases": [], "types": ["T043"], "canonical_name": "bundle-forming fimbriae-dependent aggregation"}
{"concept_id": "C5379883", "aliases": [], "types": ["T043"], "canonical_name": "bundle-forming pili-dependent aggregation"}
{"concept_id": "C5379884", "aliases": [], "types": ["T043"], "canonical_name": "tfp-dependent aggregation"}
{"concept_id": "C5379891", "aliases": [], "types": ["T026"], "canonical_name": "other organism pre-synaptic membrane"}
{"concept_id": "C5379892", "aliases": ["interorganelle junction"], "types": ["T026"], "canonical_name": "inter-organelle junction"}
{"concept_id": "C5379893", "aliases": [], "types": ["T026"], "canonical_name": "mitochondrial inner-outer membrane contact site", "definition": "Sites of close apposition of the inner and outer mitochondrial membrane. [PMID:22009199]"}
{"concept_id": "C5379894", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending", "definition": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. [GOC:jl, GOC:pg]"}
{"concept_id": "C5379895", "aliases": [], "types": ["T038"], "canonical_name": "entry into cell of other organism involved in symbiotic interaction"}
{"concept_id": "C5379896", "aliases": [], "types": ["T038"], "canonical_name": "entry into host cell"}
{"concept_id": "C5379897", "aliases": [], "types": ["T038"], "canonical_name": "entry into host cell via penetration peg"}
{"concept_id": "C5379898", "aliases": [], "types": ["T038"], "canonical_name": "entry into host via a specialized structure during symbiotic interaction"}
{"concept_id": "C5379899", "aliases": [], "types": ["T038"], "canonical_name": "host cell invasion"}
{"concept_id": "C5379900", "aliases": [], "types": ["T038"], "canonical_name": "invasion into other organism"}
{"concept_id": "C5379901", "aliases": ["other organism invasion"], "types": ["T038"], "canonical_name": "invasion of other organism"}
{"concept_id": "C5379902", "aliases": [], "types": ["T038"], "canonical_name": "other organism cell invasion"}
{"concept_id": "C5379903", "aliases": [], "types": ["T038"], "canonical_name": "penetration into host via a specialized structure"}
{"concept_id": "C5379904", "aliases": [], "types": ["T038"], "canonical_name": "penetration into host via a specialized structure during symbiotic interaction"}
{"concept_id": "C5379905", "aliases": ["upregulation by symbiont of host defense response", "up-regulation by symbiont of host defense response"], "types": ["T040"], "canonical_name": "up regulation by symbiont of host defense response"}
{"concept_id": "C5379906", "aliases": [], "types": ["T043"], "canonical_name": "transport of molecules into other organism during symbiotic interaction"}
{"concept_id": "C5379907", "aliases": [], "types": ["T043"], "canonical_name": "transport of DNA into other organism during symbiotic interaction"}
{"concept_id": "C5379910", "aliases": ["viral exit by cytolysis via pore formation in host cell membrane"], "types": ["T043"], "canonical_name": "viral release by cytolysis via pore formation in host cell membrane", "definition": "The killing by a virus of a cell in its host organism by cytolysis, caused by the formation by the virus of pores in its host cell membrane. [GOC:jl]"}
{"concept_id": "C5379911", "aliases": [], "types": ["T040"], "canonical_name": "acquisition by organism of nutrients from host via siderophores"}
{"concept_id": "C5379912", "aliases": [], "types": ["T044"], "canonical_name": "G protein-coupled UDP receptor activity", "definition": "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP. [GOC:mah]"}
{"concept_id": "C5379913", "aliases": [], "types": ["T044"], "canonical_name": "G protein-coupled UTP receptor activity", "definition": "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP. [GOC:mah]"}
{"concept_id": "C5379914", "aliases": [], "types": ["T044"], "canonical_name": "purinoceptor type U"}
{"concept_id": "C5379915", "aliases": [], "types": ["T044"], "canonical_name": "uridine nucleotide receptor activity"}
{"concept_id": "C5379916", "aliases": [], "types": ["T044"], "canonical_name": "G protein-coupled ATP receptor activity", "definition": "Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah]"}
{"concept_id": "C5379917", "aliases": [], "types": ["T043"], "canonical_name": "azole transmembrane transport", "definition": "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane. [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]"}
{"concept_id": "C5379918", "aliases": [], "types": ["T044"], "canonical_name": "aflatoxin B1 metabolism"}
{"concept_id": "C5379919", "aliases": [], "types": ["T044"], "canonical_name": "aflatoxin B2 metabolism"}
{"concept_id": "C5379920", "aliases": [], "types": ["T044"], "canonical_name": "3,9-dihydroxypterocarpan 6alpha-monooxygenase"}
{"concept_id": "C5379925", "aliases": [], "types": ["T044"], "canonical_name": "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity"}
{"concept_id": "C5379926", "aliases": [], "types": ["T044"], "canonical_name": "acyl-lipid omega-6 desaturase (cytochrome b5)"}
{"concept_id": "C5379927", "aliases": [], "types": ["T044"], "canonical_name": "linoleate synthase activity"}
{"concept_id": "C5379928", "aliases": [], "types": ["T044"], "canonical_name": "oleate desaturase activity"}
{"concept_id": "C5379929", "aliases": [], "types": ["T044"], "canonical_name": "oleoyl-CoA desaturase activity"}
{"concept_id": "C5379930", "aliases": [], "types": ["T044"], "canonical_name": "oleoylphosphatidylcholine desaturase activity"}
{"concept_id": "C5379933", "aliases": [], "types": ["T043"], "canonical_name": "induction by symbiont of tumor or growth in host", "definition": "The process in which a symbiont causes the formation of a mass of cells in a host organism. While these growths are often called nodules, they are not formed as nitrogen-fixing structures, but rather to provide an environment for the symbiont to grow. In this sense they are parasitic structures rather than mutualistic. [GOC:pg]"}
{"concept_id": "C5379934", "aliases": [], "types": ["T043"], "canonical_name": "modulation by host of symbiont process", "definition": "The process in which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:cc]"}
{"concept_id": "C5379935", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by symbiont of host salicylic acid-mediated defense response"}
{"concept_id": "C5379938", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by organism of defense-related host NO production"}
{"concept_id": "C5379939", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of defense-related host nitric oxide production"}
{"concept_id": "C5379940", "aliases": ["up-regulation by symbiont of defense-related host nitric oxide production", "upregulation by symbiont of defense-related host nitric oxide production"], "types": ["T040"], "canonical_name": "up regulation by symbiont of defense-related host nitric oxide production"}
{"concept_id": "C5379941", "aliases": [], "types": ["T040"], "canonical_name": "induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction"}
{"concept_id": "C5379942", "aliases": ["up-regulation by symbiont of defense-related host reactive oxygen species production", "upregulation by symbiont of defense-related host reactive oxygen species production"], "types": ["T040"], "canonical_name": "up regulation by symbiont of defense-related host reactive oxygen species production"}
{"concept_id": "C5379943", "aliases": ["phagocytosis avoidence"], "types": ["T040"], "canonical_name": "antiphagocytosis", "definition": "Any process in which a symbiont avoids phagocytosis by a host cell, for example a phagocyte or a macrophage. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06, PMID:23084912, PMID:29114249]"}
{"concept_id": "C5379944", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of entry into host via host phagocytosis"}
{"concept_id": "C5379945", "aliases": ["suppression by organism of host JA-mediated defense response"], "types": ["T040"], "canonical_name": "symbiont defense to host-produced jasmonic acid", "definition": "Any process in which a symbiont modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C5379946", "aliases": ["down-regulation by symbiont of host jasmonic acid-mediated defense response", "downregulation by symbiont of host jasmonic acid-mediated defense response"], "types": ["T040"], "canonical_name": "down regulation by symbiont of host jasmonic acid-mediated defense response"}
{"concept_id": "C5379947", "aliases": [], "types": ["T040"], "canonical_name": "induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C5379948", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C5379949", "aliases": [], "types": ["T040"], "canonical_name": "suppression by symbiont of host jasmonic acid-mediated defense response"}
{"concept_id": "C5379950", "aliases": ["up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway", "upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway"], "types": ["T040"], "canonical_name": "up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway"}
{"concept_id": "C5379951", "aliases": [], "types": ["T040"], "canonical_name": "activation by symbiont of induced systemic resistance in host"}
{"concept_id": "C5379952", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction"}
{"concept_id": "C5379953", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of induced systemic resistance in host"}
{"concept_id": "C5379954", "aliases": ["up-regulation by symbiont of induced systemic resistance in host", "upregulation by symbiont of induced systemic resistance in host"], "types": ["T040"], "canonical_name": "up regulation by symbiont of induced systemic resistance in host"}
{"concept_id": "C5379955", "aliases": [], "types": ["T040"], "canonical_name": "stimulation by symbiont of systemic acquired resistance in host"}
{"concept_id": "C5379956", "aliases": ["upregulation by symbiont of systemic acquired resistance in host", "up-regulation by symbiont of systemic acquired resistance in host"], "types": ["T040"], "canonical_name": "up regulation by symbiont of systemic acquired resistance in host"}
{"concept_id": "C5379959", "aliases": [], "types": ["T040"], "canonical_name": "defense response to host innate immune response nitric oxide production"}
{"concept_id": "C5379960", "aliases": [], "types": ["T040"], "canonical_name": "evasion by symbiont of cellular damage caused by host oxidative burst"}
{"concept_id": "C5379961", "aliases": [], "types": ["T040"], "canonical_name": "evasion or tolerance by symbiont of reactive oxygen species produced by other organism involved in symbiotic interaction"}
{"concept_id": "C5379962", "aliases": [], "types": ["T040"], "canonical_name": "response to defenses of other organism", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of another organism. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C5379963", "aliases": [], "types": ["T040"], "canonical_name": "response of symbiont to host defense molecules"}
{"concept_id": "C5379965", "aliases": ["suppression of symbiont entry into host by host"], "types": ["T040"], "canonical_name": "suppression of symbiont entry into host", "definition": "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C5379966", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host innate immunity"}
{"concept_id": "C5379967", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of host innate immune response"}
{"concept_id": "C5379968", "aliases": ["up-regulation by symbiont of host innate immunity"], "types": ["T040"], "canonical_name": "up regulation by symbiont of host innate immunity"}
{"concept_id": "C5379969", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by organism of defense-related host Ca2+ flux"}
{"concept_id": "C5379970", "aliases": ["up-regulation by symbiont of defense-related host calcium ion flux", "upregulation by symbiont of defense-related host calcium ion flux"], "types": ["T040"], "canonical_name": "up regulation by symbiont of defense-related host calcium ion flux"}
{"concept_id": "C5379971", "aliases": ["up-regulation by symbiont of host immune response"], "types": ["T040"], "canonical_name": "up regulation by symbiont of host immune response"}
{"concept_id": "C5379972", "aliases": [], "types": ["T043"], "canonical_name": "regulation of flocculation via cell wall protein-carbohydrate interaction"}
{"concept_id": "C5379973", "aliases": ["negative regulation of RNAi-mediated heterochromatin assembly"], "types": ["T045"], "canonical_name": "negative regulation of heterochromatin assembly by small RNA", "definition": "Any process that decreases the frequency, rate or extent of heterochromatin assembly by small RNA. [GOC:dph, GOC:tb]"}
{"concept_id": "C5379974", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ribosomal DNA heterochromatin assembly", "definition": "Any process that modulates the rate, frequency, or extent of the repression of assembly of rDNA heterochromatin. [GOC:dph, PMID:10388812]"}
{"concept_id": "C5379975", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of ribosomal DNA heterochromatin assembly", "definition": "Any process that decreases the rate, frequency, or extent of the repression of assembly of rDNA heterochromatin. [GOC:dph, PMID:10388812]"}
{"concept_id": "C5379976", "aliases": [], "types": ["T044"], "canonical_name": "arginine porter activity"}
{"concept_id": "C5379977", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent L-arginine transmembrane transporter activity"}
{"concept_id": "C5379978", "aliases": [], "types": ["T044"], "canonical_name": "L-arginine-importing ATPase activity"}
{"concept_id": "C5379979", "aliases": ["MutSgamma complex location"], "types": ["T026"], "canonical_name": "MutSgamma complex", "definition": "A heterodimer involved in the stabilization of DNA recombination intermediates, the promotion of crossover recombination, and the proper assembly of the synaptonemal complex in meiotic prophase nuclei. In yeast the complex consists of two subunits, Msh4 and Msh5. [PMID:27648641, PMID:7622037, PMID:8001134, PMID:9374523]"}
{"concept_id": "C5379980", "aliases": ["Msh4-Msh5 complex location"], "types": ["T026"], "canonical_name": "Msh4-Msh5 complex"}
{"concept_id": "C5379981", "aliases": ["chitin-based ECM"], "types": ["T024"], "canonical_name": "chitin-based extracellular matrix", "definition": "Any constituent part of a chitin-based noncellular, hardened, or membranous extracellular matrix secreted from the apical surface of an epithelial sheet. [PMID:23955854]"}
{"concept_id": "C5379982", "aliases": [], "types": ["T024"], "canonical_name": "adhesive extracellular matrix", "definition": "A extracellular matrix which attaches an organism to a substrate. [GOC:dph, GOC:ha, PMID:825230]"}
{"concept_id": "C5379983", "aliases": ["But-3-enyl Glucosinolate-2-hydroxylase activity"], "types": ["T044"], "canonical_name": "3-butenylglucosinolate 2-hydroxylase activity", "definition": "Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O. [PMID:18945935]"}
{"concept_id": "C5379984", "aliases": [], "types": ["T044"], "canonical_name": "regulation of L-glutamine biosynthetic process", "definition": "Any process that modulates the rate, frequency or extent of L-glutamine biosynthesis. [GOC:ha, PMID:19755423]"}
{"concept_id": "C5379985", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of L-glutamine biosynthetic process", "definition": "Any process that starts, increases the frequency, rate or extent of L-glutamine biosynthesis. [GOC:ha, PMID:19755423]"}
{"concept_id": "C5379986", "aliases": ["LDL receptor complex", "LDLR complex", "LDL receptor complex location", "low-density lipoprotein particle receptor complex location", "low-density lipoprotein particle receptor complex", "LDLR complex location", "low-density lipoprotein receptor complex location"], "types": ["T026"], "canonical_name": "low-density lipoprotein receptor complex", "definition": "A plasma membrane protein complex capable of low-density lipoprotein particle receptor activity. It may also bind xenobiotic toxins and deliver them into the cell via endocytosis. While most substrates get degraded via the endosome the receptor is recycled to the plasma membrane. It may also act as a transducer of intracellular signal pathways and often acts in corporation with other cell-surface receptors. [GOC:bhm, PMID:26005850]"}
{"concept_id": "C5379987", "aliases": ["cargo receptor complex location"], "types": ["T026"], "canonical_name": "cargo receptor complex", "definition": "Any protein complex that is part of a membrane and which functions as a cargo receptor. [PMID:27903609]"}
{"concept_id": "C5379988", "aliases": [], "types": ["T043"], "canonical_name": "camera-type eye photoreceptor cell development", "definition": "The process whose specific outcome is the progression of a light-responsive receptor in a camera-type eye over time, from its formation to the mature structure. [PMID:20648062, PMID:30237290]"}
{"concept_id": "C5379989", "aliases": [], "types": ["T026"], "canonical_name": "hyphae septin collar", "definition": "A septin collar in pathogenic fungi involved in the constriction of hyphae at the plant plasmodesma enabling penetration of an adjacent cell. [PMID:29567712]"}
{"concept_id": "C5379990", "aliases": [], "types": ["T026"], "canonical_name": "septin collar of invasive hyphae"}
{"concept_id": "C5379991", "aliases": ["nuclear exosome targeting complex location", "NEXT complex", "NEXT complex location"], "types": ["T026"], "canonical_name": "nuclear exosome targeting complex", "definition": "A protein-containing complex that functions with the RNA exosome and contributes to the degradation of abberant transcripts. [PMID:21855801, PMID:29844170]"}
{"concept_id": "C5379992", "aliases": [], "types": ["T044"], "canonical_name": "L-beta-ethynylserine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-beta-ethynylserine. L-beta-ethynylserine is an antibiotic produced by Streptomyces bacteria. [PMID:3082841, PMID:30867596]"}
{"concept_id": "C5379993", "aliases": [], "types": ["T044"], "canonical_name": "L-propargylglycine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of L-propargylglycine (Pra). L-propargylglycine is an antibiotic produced by Streptomyces bacteria. [PMID:30867596]"}
{"concept_id": "C5379994", "aliases": [], "types": ["T044"], "canonical_name": "L-propargylglycine synthase activity", "definition": "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine. [PMID:30867596, RHEA:59892]"}
{"concept_id": "C5379995", "aliases": [], "types": ["T044"], "canonical_name": "L-propargylglycine--L-glutamate ligase activity", "definition": "Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate. [PMID:30867596, RHEA:59896]"}
{"concept_id": "C5379996", "aliases": [], "types": ["T044"], "canonical_name": "4-chloro-allylglycine synthase activity", "definition": "Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+). [PMID:30867596, RHEA:59888]"}
{"concept_id": "C5379997", "aliases": [], "types": ["T044"], "canonical_name": "L-lysine 4-chlorinase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate. [PMID:30867596, RHEA:59884]"}
{"concept_id": "C5379998", "aliases": [], "types": ["T044"], "canonical_name": "L-gamma-glutamyl-L-propargylglycine hydroxylase activity", "definition": "Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate. [PMID:30867596, RHEA:59900]"}
{"concept_id": "C5379999", "aliases": [], "types": ["T042"], "canonical_name": "detection of stimulus involved in sensory perception of pain", "definition": "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. [PMID:19837031]"}
{"concept_id": "C5380000", "aliases": [], "types": ["T044"], "canonical_name": "amorpha-4,11-diene 12-monooxygenase activity", "definition": "Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. [PMID:16458889, PMID:16612385, PMID:23246612, RHEA:32999]"}
{"concept_id": "C5380001", "aliases": ["catalase complex location"], "types": ["T026"], "canonical_name": "catalase complex", "definition": "A protein-containing complex that is capable of catalase activity. [GOC:bhm, PMID:10656833]"}
{"concept_id": "C5380002", "aliases": ["mRNA (cytosine-5-)-methyltransferase activity"], "types": ["T045"], "canonical_name": "mRNA (cytidine-5-)-methyltransferase activity", "definition": "Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine. [PMID:22395603, PMID:23871666, RHEA:61464]"}
{"concept_id": "C5380003", "aliases": ["C5-methylcytosine-containing RNA binding"], "types": ["T045"], "canonical_name": "C5-methylcytidine-containing RNA binding", "definition": "Binding to an RNA molecule modified by C5-methylcytidine. [PMID:28418038]"}
{"concept_id": "C5380004", "aliases": ["MAPDA"], "types": ["T044"], "canonical_name": "N6-mAMP deaminase activity", "definition": "Catalysis of the reaction: H(+) + H2O + N6-methyl-AMP = IMP + methylamine. [PMID:29884623, RHEA:16001]"}
{"concept_id": "C5380005", "aliases": ["curli secretion complex location"], "types": ["T026"], "canonical_name": "curli secretion complex", "definition": "A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms. [PMID:25219853]"}
{"concept_id": "C5380006", "aliases": ["mitoK-ATP activity", "mitochondrial potassium channel activity"], "types": ["T044"], "canonical_name": "mitochondrial ATP-gated potassium channel activity", "definition": "Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane. [PMID:31435016]"}
{"concept_id": "C5380007", "aliases": ["mitochondrial ATP-gated potassium channel complex location"], "types": ["T026"], "canonical_name": "mitochondrial ATP-gated potassium channel complex", "definition": "A protein-containing complex that is capable of the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane. [PMID:31435016]"}
{"concept_id": "C5380008", "aliases": [], "types": ["T044"], "canonical_name": "chloride:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out). [PMID:14985752]"}
{"concept_id": "C5380009", "aliases": [], "types": ["T026"], "canonical_name": "spongiome", "definition": "A cellular anatomical entity which is a network of tubules and vessicles and is part of the contractile vacuole complex. It is involved in the discharge of water externally. One of its functions is osmoregulatory. [PMID:23890380]"}
{"concept_id": "C5380010", "aliases": ["regulation of pyocyanin biosynthetic process"], "types": ["T044"], "canonical_name": "regulation of pyocyanine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of a pyocyanine biosynthetic process. [PMID:28715477]"}
{"concept_id": "C5380011", "aliases": ["positive regulation of pyocyanin biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of pyocyanine biosynthetic process", "definition": "Any process that increases the frequency, rate or extent of a pyocyanine biosynthetic process. [PMID:28715477]"}
{"concept_id": "C5380012", "aliases": [], "types": ["T043"], "canonical_name": "regulation of pseudohyphal septin ring assembly", "definition": "Any process that modulates the rate, frequency or extent of pseudohyphal septin ring assembly. [PMID:29567712]"}
{"concept_id": "C5380013", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of pseudohyphal septin ring assembly", "definition": "Any process that increases the rate, frequency or extent of pseudohyphal septin ring formation. [PMID:29567712]"}
{"concept_id": "C5380014", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of pseudohyphal septin ring assembly", "definition": "Any process that decreases the rate, frequency or extent of pseudohyphal septin ring assembly. [PMID:29567712]"}
{"concept_id": "C5380015", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of plus-end directed microtubule sliding", "definition": "Any process that stops, prevents, or reduces the frequency, rate, or extent of plus-end directed microtubule sliding. [PMID:21892183]"}
{"concept_id": "C5380016", "aliases": [], "types": ["T043"], "canonical_name": "regulation of plus-end directed microtubule sliding", "definition": "Any process that mediates the frequency, rate, or extent of plus-end directed microtubule sliding. [PMID:21892183]"}
{"concept_id": "C5380017", "aliases": ["lutein metabolism"], "types": ["T044"], "canonical_name": "lutein metabolic process", "definition": "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform lutein. [PMID:24397433]"}
{"concept_id": "C5380018", "aliases": ["lutein formation", "lutein biosynthesis", "lutein anabolism"], "types": ["T044"], "canonical_name": "lutein biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lutein. [PMID:24397433]"}
{"concept_id": "C5380019", "aliases": ["lutein catabolism", "lutein breakdown", "lutein degradation"], "types": ["T044"], "canonical_name": "lutein catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of lutein. [PMID:24397433]"}
{"concept_id": "C5380020", "aliases": ["allopregnanolone metabolic process", "allotetrahydroprogesterone metabolic process", "allopregnanolone metabolism", "brexanolone metabolism", "allotetrahydroprogesterone metabolism"], "types": ["T044"], "canonical_name": "brexanolone metabolic process", "definition": "The chemical reactions and pathways by which living organisms transform brexanolone. [PMID:24390875]"}
{"concept_id": "C5380021", "aliases": ["allopregnanolone synthesis", "brexanolone biosynthesis", "allopregnanolone biosynthetic process", "allopregnanolone anabolism", "allotetrahydroprogesterone anabolism", "allotetrahydroprogesterone synthesis", "brexanolone synthesis", "allotetrahydroprogesterone biosynthetic process", "allotetrahydroprogesterone biosynthesis", "allopregnanolone biosynthesis", "brexanolone anabolism"], "types": ["T044"], "canonical_name": "brexanolone biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of brexanolone. [PMID:24390875]"}
{"concept_id": "C5380022", "aliases": ["brexanolone catabolism", "allotetrahydroprogesterone catabolism", "allotetrahydroprogesterone catabolic process", "allopregnanolone degradation", "allotetrahydroprogesterone degradation", "allopregnanolone catabolic process", "brexanolone degradation", "allopregnanolone breakdown", "allotetrahydroprogesterone breakdown", "brexanolone breakdown", "allopregnanolone catabolism"], "types": ["T044"], "canonical_name": "brexanolone catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of brexanolone. [PMID:24390875]"}
{"concept_id": "C5380023", "aliases": [], "types": ["T045"], "canonical_name": "R-loop disassembly", "definition": "A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability. [PMID:28790157]"}
{"concept_id": "C5380024", "aliases": [], "types": ["T043"], "canonical_name": "radial spoke assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the radial spoke, a protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. [PMID:21613541, PMID:21692193, PMID:24124175, PMID:27940518, PMID:8408197]"}
{"concept_id": "C5380025", "aliases": [], "types": ["T044"], "canonical_name": "vitamin D 23-hydroxylase activity", "definition": "Catalysis of the hydroxylation of C-23 of any form of vitamin D. [PMID:22100522, PMID:30205156]"}
{"concept_id": "C5380026", "aliases": [], "types": ["T044"], "canonical_name": "25-hydroxycholecalciferol-23-hydroxylase activity", "definition": "Catalysis of the reaction: calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]. [PMID:22100522, PMID:30205156, RHEA:46616]"}
{"concept_id": "C5380027", "aliases": [], "types": ["T044"], "canonical_name": "1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity", "definition": "Catatlysis of the reaction: calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]. [PMID:22100522, PMID:30205156, RHEA:49192]"}
{"concept_id": "C5380028", "aliases": [], "types": ["T044"], "canonical_name": "all-trans retinoic acid 4-hydrolase activity", "definition": "Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. [PMID:9250660, PMID:9716180, RHEA:51492]"}
{"concept_id": "C5380029", "aliases": [], "types": ["T044"], "canonical_name": "all-trans retinoic acid 18-hydroxylase activity", "definition": "Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. [PMID:22020119, RHEA:55856]"}
{"concept_id": "C5380030", "aliases": [], "types": ["T044"], "canonical_name": "testosterone 16-beta-hydroxylase activity", "definition": "Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. [PMID:21289075, RHEA:46304]"}
{"concept_id": "C5380031", "aliases": [], "types": ["T044"], "canonical_name": "secalciferol 1-monooxygenase activity", "definition": "Catalysis of the reaction:2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]. [PMID:10518789, RHEA:49064]"}
{"concept_id": "C5380032", "aliases": ["arachidonoylethanolamide epoxidase activity"], "types": ["T044"], "canonical_name": "anandamide epoxidase activity", "definition": "Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide. [PMID:21289075]"}
{"concept_id": "C5380033", "aliases": [], "types": ["T044"], "canonical_name": "anandamide 8,9 epoxidase activity", "definition": "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]. [PMID:21289075, RHEA:53140]"}
{"concept_id": "C5380034", "aliases": [], "types": ["T044"], "canonical_name": "anandamide 11,12 epoxidase activity", "definition": "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]. [PMID:21289075, RHEA:53144]"}
{"concept_id": "C5380035", "aliases": [], "types": ["T044"], "canonical_name": "anandamide 14,15 epoxidase activity", "definition": "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]. [PMID:21289075, RHEA:53148]"}
{"concept_id": "C5380036", "aliases": ["galactoxylomannan biosynthesis", "GalXM biosynthetic process", "galactoxylomannan formation", "glucuronoxylomannogalactan biosynthetic process", "galactoxylomannan synthesis", "galactoxylomannan anabolism"], "types": ["T044"], "canonical_name": "galactoxylomannan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactoxylomannan. Galactoxylomannan is produced by a pathogenic fungus and causes paralysis in some animals. [PMID:16441437, PMID:18952901, PMID:19684080, PMID:21843086]"}
{"concept_id": "C5380037", "aliases": [], "types": ["T044"], "canonical_name": "L-rhamnose mutarotase activity", "definition": "Catalysis of the reaction: alpha-L-rhamnose = beta-L-rhamnose. [RHEA:25584]"}
{"concept_id": "C5380038", "aliases": [], "types": ["T044"], "canonical_name": "D-ribose pyranase activity", "definition": "Catalysis of the reaction: beta-D-ribopyranose = beta-D-ribofuranose. [RHEA:25432]"}
{"concept_id": "C5380039", "aliases": [], "types": ["T026"], "canonical_name": "cytoplasmic microtubule minus-end", "definition": "A microtubule minus end that is part of a cytoplasmic microtubule. [PMID:18061564]"}
{"concept_id": "C5380040", "aliases": [], "types": ["T043"], "canonical_name": "microtubule bundle maintenance", "definition": "The organization process that preserves a microtubule bundle in a stable functional or structural state. [PMID:18061564]"}
{"concept_id": "C5380041", "aliases": [], "types": ["T043"], "canonical_name": "regulation of lysosome size", "definition": "Any process that modulates the size of a lysosome. [PMID:31314175]"}
{"concept_id": "C5380042", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to chemical stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress. [PMID:26653712]"}
{"concept_id": "C5380044", "aliases": [], "types": ["T026"], "canonical_name": "chromosome, centromeric inner repeat region", "definition": "The portion of the centromeric region of a chromosome that contains the inner inverted repeat region of a modular centromere and part of the central core surrounding a non-conserved central region. This region is adjacent to the central core, on each chromosome arm. [PMID:21437270]"}
{"concept_id": "C5380045", "aliases": ["morphogenesis Orb6 network"], "types": ["T044"], "canonical_name": "RAM/MOR signaling pathway", "definition": "An intracellular signaling pathway that regulates interphase polarized growth and cell separation at the end of cytokinesis through activation of the NDR1/2-related kinase. [PMID:15731009, PMID:16096637, PMID:20805322, PMID:20826805, PMID:21246752, PMID:22629372]"}
{"concept_id": "C5380046", "aliases": [], "types": ["T044"], "canonical_name": "MOR signaling pathway"}
{"concept_id": "C5380047", "aliases": [], "types": ["T044"], "canonical_name": "RAM signaling pathway"}
{"concept_id": "C5380048", "aliases": [], "types": ["T026"], "canonical_name": "actin wave", "definition": "A cellular anatomical entity that is part of the actin cytoskeleton and results in a wave-like propagation of actin networks. It consists of dynamic structures traveling on the ventral (substrate-attached) side of the cell during cell migration, cytokinesis, adhesion and neurogenesis. [PMID:26190109, PMID:31230946, PMID:31390543, PMID:31678045, PMID:31774725]"}
{"concept_id": "C5380049", "aliases": [], "types": ["T044"], "canonical_name": "Labd-13(16),14-diene-9-ol synthase activity", "definition": "Catalysis of the reaction: peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol. [PMID:29315936, RHEA:62184]"}
{"concept_id": "C5380050", "aliases": [], "types": ["T044"], "canonical_name": "Viteagnusin D synthase activity", "definition": "Catalysis of the reaction: H2O + peregrinol diphosphate = diphosphate + viteagnusin D. [PMID:29315936, RHEA:62180]"}
{"concept_id": "C5380051", "aliases": [], "types": ["T044"], "canonical_name": "(13S)-vitexifolin A synthase activity", "definition": "Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate. [PMID:29315936, RHEA:40027]"}
{"concept_id": "C5380052", "aliases": [], "types": ["T044"], "canonical_name": "miltiradiene synthase activity", "definition": "Catalysis of the reaction: (+)-copalyl diphosphate = diphosphate + miltiradiene. [PMID:24990389, RHEA:33983]"}
{"concept_id": "C5380053", "aliases": [], "types": ["T044"], "canonical_name": "manoyl oxide synthase activity", "definition": "Catalysis of the reaction: 8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate. [PMID:24990389, RHEA:54516]"}
{"concept_id": "C5380054", "aliases": [], "types": ["T044"], "canonical_name": "regulation of pattern recognition receptor signaling pathway", "definition": "Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway. [PMID:30610168]"}
{"concept_id": "C5380055", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of pattern recognition receptor signaling pathway", "definition": "Any process that decreases the rate, frequency or extent of a pattern recognition receptor signaling pathway. [PMID:30610168]"}
{"concept_id": "C5380056", "aliases": ["regulation of spatial distribution of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "regulation of spatial distribution of meiotic DSB formation involved in reciprocal meiotic recombination"], "types": ["T043"], "canonical_name": "spatial regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination", "definition": "Any process that modulates the distribution of sites along the chromosome where meiotic DNA double-strand break formation takes place as part of reciprocal meiotic recombination. [PMID:25324213, PMID:30217891]"}
{"concept_id": "C5380057", "aliases": [], "types": ["T043"], "canonical_name": "crossover interference"}
{"concept_id": "C5380058", "aliases": [], "types": ["T045"], "canonical_name": "DSB interference"}
{"concept_id": "C5380059", "aliases": ["shoot system regeneration"], "types": ["T042"], "canonical_name": "shoot regeneration", "definition": "The regeneration process by which a damaged or lost shoot regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to produce a new shoot meristem and subsequently a new shoot. [PMID:27143753]"}
{"concept_id": "C5380060", "aliases": [], "types": ["T042"], "canonical_name": "root regeneration", "definition": "The the regeneration process by which a damaged or lost root regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to form a new root meristem and subsequently new root. [PMID:27143753]"}
{"concept_id": "C5380061", "aliases": ["regulation of early replication origin firing"], "types": ["T045"], "canonical_name": "regulation of mitotic DNA replication initiation from early origin", "definition": "Any process that modulates the frequency, rate or extent of firing from an early origin of replication involved in mitotic DNA replication. [PMID:22279046]"}
{"concept_id": "C5380062", "aliases": [], "types": ["T044"], "canonical_name": "peroxynitrite isomerase activity", "definition": "Catalysis of the reaction: peroxynitrite = nitrate. [PMID:30524950, RHEA:63116]"}
{"concept_id": "C5380063", "aliases": [], "types": ["T039"], "canonical_name": "regulation of somatic muscle development", "definition": "Any process that regulates the rate, frequency or extent of somatic muscle development. [PMID:16643882, PMID:25758712]"}
{"concept_id": "C5380064", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of somatic muscle development", "definition": "Any process that increases the rate, frequency or extent of somatic muscle development. [PMID:16643882, PMID:25758712]"}
{"concept_id": "C5380065", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of somatic muscle development", "definition": "Any process that decreases the rate, frequency or extent of somatic muscle development. [PMID:16643882, PMID:25758712]"}
{"concept_id": "C5380066", "aliases": [], "types": ["T039"], "canonical_name": "regulation of adult somatic muscle development", "definition": "Any process that modulates the rate, frequency or extent of adult somatic muscle development. [PMID:16643882, PMID:25758712]"}
{"concept_id": "C5380067", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of adult somatic muscle development", "definition": "Any process that increases the rate, frequency or extent of adult somatic muscle development. [PMID:16643882, PMID:25758712]"}
{"concept_id": "C5380068", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of adult somatic muscle development", "definition": "Any process that decreases the rate, frequency or extent of adult somatic muscle development. [PMID:16643882, PMID:25758712]"}
{"concept_id": "C5380069", "aliases": [], "types": ["T039"], "canonical_name": "regulation of larval somatic muscle development", "definition": "Any process that modulates the rate, frequency or extent of larval somatic muscle development. [PMID:16643882, PMID:25758712]"}
{"concept_id": "C5380070", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of larval somatic muscle development", "definition": "Any process that decreases the rate, frequency or extent of larval somatic muscle development. [PMID:16643882, PMID:25758712]"}
{"concept_id": "C5380071", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of larval somatic muscle development", "definition": "Any process that increases the rate, frequency or extent of larval somatic muscle development. [PMID:16643882, PMID:25758712]"}
{"concept_id": "C5380072", "aliases": [], "types": ["T044"], "canonical_name": "prostanoid catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of prostanoids. [PMID:25449649]"}
{"concept_id": "C5380073", "aliases": [], "types": ["T044"], "canonical_name": "F2-isoprostane catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of F2-isoprostane. [PMID:16371369, PMID:25449649]"}
{"concept_id": "C5380074", "aliases": ["2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine catabolic process", "PAF catabolic process"], "types": ["T044"], "canonical_name": "platelet activating factor catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of platelet activating factor, 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine. [PMID:16371369]"}
{"concept_id": "C5380075", "aliases": ["axoneme basal plate assembly"], "types": ["T043"], "canonical_name": "axonemal basal plate assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an axonemal basal plate. [PMID:23352055, PMID:30810527]"}
{"concept_id": "C5380076", "aliases": [], "types": ["T043"], "canonical_name": "axonemal basal plate formation"}
{"concept_id": "C5380077", "aliases": [], "types": ["T043"], "canonical_name": "basal plate assembly"}
{"concept_id": "C5380078", "aliases": [], "types": ["T043"], "canonical_name": "ionocyte differentiation", "definition": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an ionocyte. Ionocytes are specialized epithelial cells that contribute to osmotic homeostasis. [PMID:17555741]"}
{"concept_id": "C5380079", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to postsynapse", "definition": "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. [PMID:31189538]"}
{"concept_id": "C5380080", "aliases": ["Smp dot"], "types": ["T026"], "canonical_name": "Smp focus", "definition": "A DNA-binding ribonucleoprotein complex that contains a lncRNA complementary to the bound chromosomal locus and is involved in the tethering homologous chromosomes together during chromosome pairing at meiotic prophase I. [PMID:22582262, PMID:31811152]"}
{"concept_id": "C5380081", "aliases": ["nuclear membrane-heterochromatin anchor activity", "nuclear membrane-heterochromatin tether activity", "heterochromatin-nuclear membrane tether activity"], "types": ["T044"], "canonical_name": "heterochromatin-nuclear membrane anchor activity", "definition": "Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization. [PMID:31635174]"}
{"concept_id": "C5380082", "aliases": ["euchromatin-nuclear membrane tether activity", "nuclear membrane-euchromatin tether activity", "nuclear membrane-euchromatin anchor activity"], "types": ["T044"], "canonical_name": "euchromatin-nuclear membrane anchor activity", "definition": "Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization. [PMID:31635174]"}
{"concept_id": "C5380083", "aliases": [], "types": ["T044"], "canonical_name": "double strand break-nuclear membrane anchor activity", "definition": "Binding to DNA double strand breaks and the nuclear inner membrane, in order to facilitate DNA repair. [PMID:31635174]"}
{"concept_id": "C5380084", "aliases": [], "types": ["T044"], "canonical_name": "DNA repair factory"}
{"concept_id": "C5380085", "aliases": ["membrane of double membrane vesicle viral factory"], "types": ["T026"], "canonical_name": "double membrane vesicle viral factory membrane", "definition": "One of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory. [PMID:22440839]"}
{"concept_id": "C5380086", "aliases": ["outer membrane of double membrane vesicle viral factory"], "types": ["T026"], "canonical_name": "double membrane vesicle viral factory outer membrane", "definition": "The outer of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory. [PMID:22440839]"}
{"concept_id": "C5380087", "aliases": ["lumen of double membrane vesicle viral factory"], "types": ["T026"], "canonical_name": "double membrane vesicle viral factory lumen", "definition": "The volume surrounded by the inner membrane of a double membrane vesicle viral factory. [PMID:22440839]"}
{"concept_id": "C5380088", "aliases": ["inner membrane of double membrane vesicle viral factory"], "types": ["T026"], "canonical_name": "double membrane vesicle viral factory inner membrane", "definition": "The inner of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory. [PMID:22440839]"}
{"concept_id": "C5380089", "aliases": [], "types": ["T026"], "canonical_name": "exocytic vesicle lumen", "definition": "The volume enclosed by an exocytic vesicle. [PMID:27384577]"}
{"concept_id": "C5380090", "aliases": [], "types": ["T026"], "canonical_name": "chloroplast vesicle", "definition": "A intracellular vesicle that is part of a chloroplast. [PMID:32245810]"}
{"concept_id": "C5380092", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of spindle pole body localization"}
{"concept_id": "C5380093", "aliases": [], "types": ["T044"], "canonical_name": "lipoteichoic acid immune receptor activity", "definition": "Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response. [GOC:add, PMID:14665680]"}
{"concept_id": "C5380094", "aliases": [], "types": ["T040"], "canonical_name": "regulation of appressorium formation", "definition": "Any process that modulates the frequency, rate or extent of symbiont appressorium formation. [GOC:pamgo_curators]"}
{"concept_id": "C5380095", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of appressorium formation", "definition": "Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation. [GOC:pamgo_curators]"}
{"concept_id": "C5380096", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of appressorium formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont appressorium formation. [GOC:pamgo_curators]"}
{"concept_id": "C5380097", "aliases": [], "types": ["T040"], "canonical_name": "penetration peg formation", "definition": "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators, PMID:26441323]"}
{"concept_id": "C5380098", "aliases": [], "types": ["T040"], "canonical_name": "modulation of penetration peg formation", "definition": "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C5380099", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of penetration peg formation", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C5380101", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit"}
{"concept_id": "C5380104", "aliases": [], "types": ["T040"], "canonical_name": "haustorium neck formation", "definition": "The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators, Wikipedia:Haustorium]"}
{"concept_id": "C5380105", "aliases": [], "types": ["T040"], "canonical_name": "penetration hypha formation", "definition": "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process in which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators, PMID:26441323]"}
{"concept_id": "C5380106", "aliases": [], "types": ["T040"], "canonical_name": "active spore dispersal on or near host"}
{"concept_id": "C5380107", "aliases": [], "types": ["T040"], "canonical_name": "active spore dispersal on or near host during symbiotic interaction"}
{"concept_id": "C5380108", "aliases": [], "types": ["T040"], "canonical_name": "activation by organism of defense response in host by specific elicitors"}
{"concept_id": "C5380109", "aliases": [], "types": ["T044"], "canonical_name": "avirulence protein"}
{"concept_id": "C5380110", "aliases": [], "types": ["T040"], "canonical_name": "effector-triggered induction of host innate immune response"}
{"concept_id": "C5380111", "aliases": [], "types": ["T040"], "canonical_name": "effector-triggered induction of plant hypersensitive response by symbiont"}
{"concept_id": "C5380112", "aliases": [], "types": ["T043"], "canonical_name": "effector-triggered necrosis"}
{"concept_id": "C5380113", "aliases": ["ETI-triggered of host innate immune response"], "types": ["T040"], "canonical_name": "ETI triggered of host innate immune response"}
{"concept_id": "C5380114", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of defense response in host by specific elicitors"}
{"concept_id": "C5380115", "aliases": [], "types": ["T040"], "canonical_name": "induction by organism of pathogen-race/host plant cultivar-specific resistance in host"}
{"concept_id": "C5380116", "aliases": [], "types": ["T040"], "canonical_name": "induction of effector-triggered immunity (ETI)"}
{"concept_id": "C5380117", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation by organism of defense response in host by specific elicitors"}
{"concept_id": "C5380118", "aliases": [], "types": ["T026"], "canonical_name": "hyphal membrane", "definition": "A host-derived membrane surrounding the symbiont hypha during infection. [GOC:pamgo_curators]"}
{"concept_id": "C5380119", "aliases": [], "types": ["T045"], "canonical_name": "regulation of DNA methylation-dependent heterochromatin assembly", "definition": "Any process that modulates the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin. [GOC:BHF]"}
{"concept_id": "C5380120", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA methylation-dependent heterochromatin assembly", "definition": "Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin. [GOC:BHF]"}
{"concept_id": "C5380121", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of DNA methylation-dependent heterochromatin assembly", "definition": "Any process that decreases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin. [GOC:BHF]"}
{"concept_id": "C5380122", "aliases": ["RNA polymerase II transcription regulator complex location"], "types": ["T026"], "canonical_name": "RNA polymerase II transcription regulator complex", "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]"}
{"concept_id": "C5380123", "aliases": ["RNA polymerase III transcription regulator complex location"], "types": ["T026"], "canonical_name": "RNA polymerase III transcription regulator complex", "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III. [GOC:tb]"}
{"concept_id": "C5380124", "aliases": ["RNA polymerase IV transcription regulator complex location"], "types": ["T026"], "canonical_name": "RNA polymerase IV transcription regulator complex", "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV. [GOC:tb]"}
{"concept_id": "C5380125", "aliases": ["RNA polymerase V transcription regulator complex location"], "types": ["T026"], "canonical_name": "RNA polymerase V transcription regulator complex", "definition": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V. [GOC:tb]"}
{"concept_id": "C5380126", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled L-glutamate tranmembrane transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in). [EC:7.4.2.1]"}
{"concept_id": "C5380127", "aliases": ["cytoskeletal protein membrane adaptor", "membrane-cytoskeletal protein anchor activity", "cytoskeletal protein membrane anchor activity", "cytoskeletal protein-membrane adaptor activity"], "types": ["T044"], "canonical_name": "cytoskeletal protein-membrane anchor activity", "definition": "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location. [PMID:25736293, PMID:30840879]"}
{"concept_id": "C5380128", "aliases": [], "types": ["T044"], "canonical_name": "BAR domain adaptor"}
{"concept_id": "C5380129", "aliases": [], "types": ["T044"], "canonical_name": "F-BAR domain adaptor"}
{"concept_id": "C5380130", "aliases": ["5-PP-InsP4 activity", "5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate diphosphatase activity", "5-diphosphoinositol 1,3,4,6-tetrakisphosphate diphosphatase activity"], "types": ["T044"], "canonical_name": "inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity", "definition": "Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate. [GOC:rn, PMID:29540476]"}
{"concept_id": "C5380131", "aliases": ["centromere detachment from spindle pole body involved in chromosome organization involved in meiotic cell cycle", "centromere detachment from SPB involved in meiotic chromosome organization"], "types": ["T043"], "canonical_name": "centromere detachment from spindle pole body involved in meiotic chromosome organization", "definition": "The cell cycle process in which centromeres dissociate from the spindle pole body, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I. [GOC:mah, PMID:27611693]"}
{"concept_id": "C5380132", "aliases": ["kinetochore disassembly from spindle pole body involved in chromosome organization involved in meiotic cell cycle"], "types": ["T043"], "canonical_name": "kinetochore disassembly involved in meiotic chromosome organization", "definition": "The cell cycle process in which outer kinetochore components delocalize from the centromere, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I. [GOC:mah, PMID:27611693]"}
{"concept_id": "C5380133", "aliases": [], "types": ["T043"], "canonical_name": "regulation of vesicle fusion with Golgi apparatus", "definition": "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus. [GOC:se, PMID:26195667]"}
{"concept_id": "C5380134", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of vesicle fusion with Golgi apparatus", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus. [GOC:se, PMID:26195667]"}
{"concept_id": "C5380135", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of vesicle fusion with Golgi apparatus", "definition": "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus. [GOC:se, PMID:26195667]"}
{"concept_id": "C5380136", "aliases": [], "types": ["T045"], "canonical_name": "tRNA C3-cytosine methylation", "definition": "The process whereby a cytosine in a tRNA is methylated at position 3 of the cytosine. [PMID:28655767]"}
{"concept_id": "C5380137", "aliases": ["GAG biosynthetic process", "galactosaminogalactan biosynthesis"], "types": ["T044"], "canonical_name": "galactosaminogalactan biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactosaminogalactan. GAG is a heteropolysaccharide composed of alpha-1,4 linked galactose, N-acetyl galactosamine (GalNAc) and galactosamine (GalN). [PMID:173713, PMID:22102815, PMID:24257745, PMID:26492565, PMID:26932183, PMID:27048799, PMID:30667338]"}
{"concept_id": "C5380138", "aliases": [], "types": ["T044"], "canonical_name": "galactosaminogalactan anabolism"}
{"concept_id": "C5380139", "aliases": [], "types": ["T044"], "canonical_name": "galactosaminogalactan formation"}
{"concept_id": "C5380140", "aliases": [], "types": ["T044"], "canonical_name": "galactosaminogalactan synthesis"}
{"concept_id": "C5380141", "aliases": [], "types": ["T044"], "canonical_name": "zinc ion sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc. [GOC:vw, PMID:31239353]"}
{"concept_id": "C5380142", "aliases": ["pyocyanin biosynthetic process"], "types": ["T044"], "canonical_name": "pyocyanine biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyrocyanin, an iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group. [PMID:28715477]"}
{"concept_id": "C5380143", "aliases": ["long noncoding RNA binding"], "types": ["T045"], "canonical_name": "lncRNA binding", "definition": "Binding to a long noncoding RNA (lncRNA). [PMID:25578728]"}
{"concept_id": "C5380144", "aliases": [], "types": ["T044"], "canonical_name": "germacrene A hydroxylase activity", "definition": "Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. [PMID:11299372, PMID:20351109, RHEA:30303]"}
{"concept_id": "C5380145", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine 2-hydroxyisobutyrylation", "definition": "The 2-hydroxyisobutyrylation of a lysine residue in a protein. [GOC:sp, PMID:29775581]"}
{"concept_id": "C5380146", "aliases": [], "types": ["T044"], "canonical_name": "peptide 2-hydroxyisobutyryltransferase activity", "definition": "Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide. [GOC:sp, PMID:29775581]"}
{"concept_id": "C5380147", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-lysine glutarylation", "definition": "The glutarylation of a lysine residue in a protein. [GOC:sp, PMID:31542297]"}
{"concept_id": "C5380148", "aliases": [], "types": ["T044"], "canonical_name": "peptide glutaryltransferase activity", "definition": "Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]. [GOC:sp, PMID:31542297]"}
{"concept_id": "C5380149", "aliases": [], "types": ["T044"], "canonical_name": "histone glutaryltransferase activity", "definition": "Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone. [GOC:sp, PMID:31542297]"}
{"concept_id": "C5380150", "aliases": [], "types": ["T044"], "canonical_name": "protein depropionylation", "definition": "The removal of a propionyl group from a residue in a peptide or protein. [GOC:sp, PMID:30026585]"}
{"concept_id": "C5380151", "aliases": [], "types": ["T044"], "canonical_name": "protein-propionyllysine depropionylase activity", "definition": "Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. [GOC:sp, PMID:30026585, RHEA:23500]"}
{"concept_id": "C5380152", "aliases": ["hydroxyisourate hydrolase complex location"], "types": ["T026"], "canonical_name": "hydroxyisourate hydrolase complex", "definition": "A hydrolase complex that converts 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline. This is the second step of the three-step enzymatic reaction that degrades uric acid to (S)-allantoin. [GOC:bhm, PMID:21795808]"}
{"concept_id": "C5380153", "aliases": ["5-hydroxyisourate hydrolase complex location"], "types": ["T026"], "canonical_name": "5-hydroxyisourate hydrolase complex"}
{"concept_id": "C5380154", "aliases": ["HIU hydrolase complex location"], "types": ["T026"], "canonical_name": "HIU hydrolase complex"}
{"concept_id": "C5380155", "aliases": ["HIUH complex location"], "types": ["T026"], "canonical_name": "HIUH complex"}
{"concept_id": "C5380156", "aliases": ["glycosome organisation"], "types": ["T043"], "canonical_name": "glycosome organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a glycosome, a membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis. [GOC:ach, PMID:15539076, PMID:28426655, PMID:31341002, PMID:8056787]"}
{"concept_id": "C5380157", "aliases": [], "types": ["T043"], "canonical_name": "glycosome biogenesis"}
{"concept_id": "C5380158", "aliases": [], "types": ["T043"], "canonical_name": "glycosome organization and biogenesis"}
{"concept_id": "C5380159", "aliases": ["outer membrane protein complex location"], "types": ["T026"], "canonical_name": "outer membrane protein complex", "definition": "Any protein complex that is part of the bacterial outer membrane. An example In E.coli, is RcsF associated with any one of several outer membrane beta-barrel proteins (OMPs), such as OmpA, OmpF, or OmpcC. [GOC:am, PMID:25267629, PMID:27282389]"}
{"concept_id": "C5380160", "aliases": [], "types": ["T044"], "canonical_name": "ceramide-1-phosphate phosphatase activity", "definition": "Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate. [GOC:lb, PMID:10359651]"}
{"concept_id": "C5380161", "aliases": [], "types": ["T044"], "canonical_name": "rhamnolipid biosynthesis", "definition": "The chemical reactions and pathways resulting in the formation/production of a glycolipid surfactant that acts as a bacterial biofilm dispersal. [GOC:vw, PMID:28715477]"}
{"concept_id": "C5380162", "aliases": [], "types": ["T044"], "canonical_name": "rhamnolipid production"}
{"concept_id": "C5380163", "aliases": [], "types": ["T044"], "canonical_name": "arachidonate 12(R)-lipoxygenase activity", "definition": "Catalysis of the reaction: arachidonate + O(2)=(5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. [GOC:gap, PMID:10100631, PMID:11256953, RHEA:41336]"}
{"concept_id": "C5380164", "aliases": [], "types": ["T044"], "canonical_name": "peregrinol diphosphate synthase activity", "definition": "Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O. [GOC:emb, PMID:24990389, PMID:29315936, RHEA:54652]"}
{"concept_id": "C5380165", "aliases": [], "types": ["T044"], "canonical_name": "9,13-epoxylabda-14-ene synthase activity", "definition": "Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate. [GOC:emb, PMID:24990389, RHEA:54512]"}
{"concept_id": "C5380166", "aliases": [], "types": ["T044"], "canonical_name": "labd-13Z-ene-9,15,16-triol synthase activity", "definition": "Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]. [GOC:eab, PMID:29315936, RHEA:62192]"}
{"concept_id": "C5380167", "aliases": [], "types": ["T044"], "canonical_name": "kolavenyl diphosphate synthase activity", "definition": "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate. [GOC:eab, PMID:29315936, RHEA:54676]"}
{"concept_id": "C5380168", "aliases": [], "types": ["T044"], "canonical_name": "syn-isopimara-7,15-diene synthase activity", "definition": "Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene. [GOC:emb, PMID:29315936, RHEA:62188]"}
{"concept_id": "C5380169", "aliases": [], "types": ["T044"], "canonical_name": "eupatolide synthase activity", "definition": "Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:eab, PMID:29758164, RHEA:57972]"}
{"concept_id": "C5380170", "aliases": [], "types": ["T044"], "canonical_name": "L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "definition": "Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine. [PMID:19014349, PMID:31869331, RHEA:27606]"}
{"concept_id": "C5380171", "aliases": [], "types": ["T045"], "canonical_name": "regulation of poly(A)-specific ribonuclease activity", "definition": "Any process that modulates the rate, frequency or extent of the catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. [GOC:mah, PMID:29932902]"}
{"concept_id": "C5380172", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of poly(A)-specific ribonuclease activity", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of poly(A)-specific ribonuclease activity. [GOC:mah, PMID:29932902]"}
{"concept_id": "C5380173", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of poly(A)-specific ribonuclease activity", "definition": "Any process that activates or increases the frequency, rate or extent of poly(A)-specific ribonuclease activity. [GOC:mah, PMID:29932902]"}
{"concept_id": "C5380174", "aliases": ["Nicalin-TMEM147-NOMO complex location", "Nicalin-NOMO complex location", "Nicalin-TMEM147-NOMO complex"], "types": ["T026"], "canonical_name": "Nicalin-NOMO complex", "definition": "A protein complex regulating Nodal signaling. Subunits are highly conserved in vertebrates and include Nicalin, NOMO and TMEM147. [GOC:al, GOC:bhm, PMID:20538592]"}
{"concept_id": "C5380175", "aliases": [], "types": ["T045"], "canonical_name": "DNA-binding transcription repressor activity, RNA polymerase III-specific", "definition": "A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III. [GOC:txnOH-2018, PMID:15590667, PMID:31833215]"}
{"concept_id": "C5380176", "aliases": [], "types": ["T044"], "canonical_name": "N4-acetylcytidine amidohydrolase activity", "definition": "Catalysis of the reaction N4-acetylcytidine +H2O = cytidine + acetate. [GOC:imk, PMID:31964920, RHEA:62932]"}
{"concept_id": "C5380177", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of DNA strand resection involved in replication fork processing", "definition": "Any process that activates or increases the frequency, rate or extent of DNA strand resection involved in replication fork processing. [GOC:vw, PMID:31575705]"}
{"concept_id": "C5380178", "aliases": ["lipid sensing activity"], "types": ["T044"], "canonical_name": "lipid sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid. [GOC:vw, PMID:30075144]"}
{"concept_id": "C5380179", "aliases": [], "types": ["T044"], "canonical_name": "hydroperoxy icosatetraenoate isomerase activity", "definition": "A hydroperoxy icosatetraenoate <=> a hydroxy epoxy icosatrienoate. [PMID:12881489, RHEA:55560]"}
{"concept_id": "C5380180", "aliases": [], "types": ["T044"], "canonical_name": "hydroperoxy icosatetraenoate dehydratase activity", "definition": "A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O. [PMID:12881489, RHEA:55556]"}
{"concept_id": "C5380182", "aliases": [], "types": ["T044"], "canonical_name": "L-serine-phosphatidylcholine phosphatidyltransferase activity", "definition": "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline. [PMID:19014349., RHEA:45088]"}
{"concept_id": "C5380183", "aliases": [], "types": ["T040"], "canonical_name": "cell-to-cell migration in host", "definition": "The directional movement of a symbiont from one host cell to another. [GOC:vw, PMID:29567712]"}
{"concept_id": "C5380184", "aliases": ["regulation of mineralisation", "regulation of biomineralisation", "regulation of mineralization", "regulation of biomineral formation"], "types": ["T038"], "canonical_name": "regulation of biomineralization", "definition": "Any process that modulates the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. [PMID:22992051]"}
{"concept_id": "C5380185", "aliases": [], "types": ["T039"], "canonical_name": "negative regulation of biomineral formation"}
{"concept_id": "C5380186", "aliases": ["positive regulation of mineralization", "positive regulation of biomineralisation", "positive regulation of biomineral formation", "positive regulation of mineralisation"], "types": ["T038"], "canonical_name": "positive regulation of biomineralization", "definition": "Any process that activates or increases the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. [PMID:22992051]"}
{"concept_id": "C5380187", "aliases": [], "types": ["T044"], "canonical_name": "RNA NAD-cap (NAD-forming) hydrolase activity", "definition": "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+). [GOC:sp, PMID:28283058, RHEA:60880]"}
{"concept_id": "C5380188", "aliases": [], "types": ["T044"], "canonical_name": "RNA NAD-cap (NMN-forming) hydrolase activity", "definition": "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+). [GOC:sp, PMID:25533955, PMID:31101919, RHEA:60876]"}
{"concept_id": "C5380189", "aliases": [], "types": ["T045"], "canonical_name": "RNA decapping", "definition": "Cleavage of the 5'-cap of an RNA. [GOC:sp, PMID:25533955, PMID:31101919]"}
{"concept_id": "C5380190", "aliases": [], "types": ["T045"], "canonical_name": "NAD-cap decapping", "definition": "Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes. [GOC:sp, PMID:25533955, PMID:28283058, PMID:31101919]"}
{"concept_id": "C5380191", "aliases": [], "types": ["T045"], "canonical_name": "methylguanosine-cap decapping", "definition": "Cleavage of the 5'-methylguanosine-cap of an mRNA. The methylguanosine-cap is present at the 5'-end of eukaryotic mRNAs. Decapping inactivates translation initiation and promotes 5'-to-3' decay of mRNA. [PMID:23287066]"}
{"concept_id": "C5380192", "aliases": ["reelin complex location"], "types": ["T026"], "canonical_name": "reelin complex", "definition": "An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain. [GOC:bhm, PMID:21844191, PMID:28887403]"}
{"concept_id": "C5380193", "aliases": ["calpain complex location"], "types": ["T026"], "canonical_name": "calpain complex", "definition": "A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate. [GOC:bhm, PMID:10639123]"}
{"concept_id": "C5380194", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic spindle formation (spindle phase one)", "definition": "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one). [GOC:vw, PMID:27697865]"}
{"concept_id": "C5380195", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic spindle formation (spindle phase one)", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one). [GOC:vw]"}
{"concept_id": "C5380196", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic spindle formation (spindle phase one)", "definition": "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one). [GOC:vw]"}
{"concept_id": "C5380197", "aliases": [], "types": ["T043"], "canonical_name": "regulation of mitotic spindle elongation (spindle phase three)", "definition": "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three). [GOC:vw, PMID:27697865]"}
{"concept_id": "C5380198", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic spindle elongation (spindle phase three)", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three). [GOC:vw, PMID:27697865]"}
{"concept_id": "C5380199", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic spindle elongation (spindle phase three)", "definition": "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three). [GOC:vw, PMID:27697865]"}
{"concept_id": "C5380200", "aliases": ["DNA biosynthetic process involved in mitochondrial DNA replication"], "types": ["T045"], "canonical_name": "DNA synthesis involved in mitochondrial DNA replication", "definition": "Any DNA biosynthetic process that is involved in mitochondrial DNA replication. [PMID:28408491, PMID:29931097]"}
{"concept_id": "C5380201", "aliases": ["regulation of histidine synthesis", "regulation of histidine anabolism", "regulation of histidine formation", "regulation of histidine biosynthesis"], "types": ["T044"], "canonical_name": "regulation of histidine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of histidine biosynthetic process. [GOC:krc]"}
{"concept_id": "C5380202", "aliases": ["down regulation of histidine biosynthesis", "downregulation of histidine formation", "down-regulation of histidine anabolism", "down regulation of histidine anabolism", "downregulation of histidine synthesis", "down regulation of histidine synthesis", "downregulation of histidine anabolism", "down-regulation of histidine synthesis", "negative regulation of histidine formation", "down regulation of histidine biosynthetic process", "negative regulation of histidine synthesis", "down-regulation of histidine formation", "negative regulation of histidine anabolism", "negative regulation of histidine biosynthesis", "down-regulation of histidine biosynthesis", "downregulation of histidine biosynthesis", "down regulation of histidine formation", "downregulation of histidine biosynthetic process", "down-regulation of histidine biosynthetic process"], "types": ["T044"], "canonical_name": "negative regulation of histidine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histidine biosynthetic process. [GOC:krc]"}
{"concept_id": "C5380203", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histidine anabolism"}
{"concept_id": "C5380204", "aliases": ["inhibition of histidine synthesis"], "types": ["T044"], "canonical_name": "inhibition of histidine biosynthesis"}
{"concept_id": "C5380205", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histidine biosynthetic process"}
{"concept_id": "C5380206", "aliases": [], "types": ["T044"], "canonical_name": "inhibition of histidine formation"}
{"concept_id": "C5380207", "aliases": ["up regulation of histidine biosynthetic process", "up-regulation of histidine biosynthesis", "up regulation of histidine synthesis", "up regulation of histidine biosynthesis", "up-regulation of histidine anabolism", "upregulation of histidine formation", "upregulation of histidine biosynthesis", "up regulation of histidine formation", "positive regulation of histidine anabolism", "upregulation of histidine biosynthetic process", "up-regulation of histidine formation", "upregulation of histidine anabolism", "up regulation of histidine anabolism", "positive regulation of histidine biosynthesis", "upregulation of histidine synthesis", "positive regulation of histidine synthesis", "up-regulation of histidine biosynthetic process", "positive regulation of histidine formation", "up-regulation of histidine synthesis"], "types": ["T044"], "canonical_name": "positive regulation of histidine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of histidine biosynthetic process. [GOC:krc]"}
{"concept_id": "C5380208", "aliases": [], "types": ["T044"], "canonical_name": "activation of histidine anabolism"}
{"concept_id": "C5380209", "aliases": ["activation of histidine formation"], "types": ["T044"], "canonical_name": "activation of histidine biosynthesis"}
{"concept_id": "C5380210", "aliases": [], "types": ["T044"], "canonical_name": "activation of histidine biosynthetic process"}
{"concept_id": "C5380211", "aliases": [], "types": ["T044"], "canonical_name": "activation of histidine synthesis"}
{"concept_id": "C5380212", "aliases": ["matrilin complex location"], "types": ["T026"], "canonical_name": "matrilin complex", "definition": "A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer. [GOC:bhm, PMID:10367731, PMID:15075323, PMID:9699631]"}
{"concept_id": "C5380213", "aliases": ["matrilin family complex location"], "types": ["T026"], "canonical_name": "matrilin family complex"}
{"concept_id": "C5380214", "aliases": ["matrilin-1 complex location"], "types": ["T026"], "canonical_name": "matrilin-1 complex"}
{"concept_id": "C5380215", "aliases": ["matrilin-2 complex location"], "types": ["T026"], "canonical_name": "matrilin-2 complex"}
{"concept_id": "C5380216", "aliases": ["matrilin-3 complex location"], "types": ["T026"], "canonical_name": "matrilin-3 complex"}
{"concept_id": "C5380217", "aliases": ["matrilin-4 complex location"], "types": ["T026"], "canonical_name": "matrilin-4 complex"}
{"concept_id": "C5380218", "aliases": ["topoisomerase II complex", "DNA gyrase complex location", "topoisomerase II complex location"], "types": ["T026"], "canonical_name": "DNA gyrase complex", "definition": "A bacterial type IIA topoisomerase that is unique in its function of introducing negative supercoils into DNA at the expense of ATP hydrolysis and is also capable of relaxing positive supercoils, an activity shared with topoisomerase IV. Typically, it is composed of two copies each of an A subunit (GyrA) and a B subunit (GyrB). [GOC:bhm, GOC:krc, PMID:1657531, PMID:20675723, Wikipedia:DNA_gyrase]"}
{"concept_id": "C5380219", "aliases": [], "types": ["T040"], "canonical_name": "host interaction involved in quorum sensing", "definition": "A quorum sensing process that is modulated by some interaction with a host cell or organism. [GOC:krc, GOC:mlg, PMID:11780122, PMID:16630813]"}
{"concept_id": "C5380220", "aliases": ["subapical region of cell"], "types": ["T026"], "canonical_name": "subapical part of cell", "definition": "The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina. [GOC:krc, PMID:29891944]"}
{"concept_id": "C5380221", "aliases": ["centriolar patch"], "types": ["T026"], "canonical_name": "basal body patch", "definition": "The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster. [GOC:krc, PMID:20164345, PMID:20685736, PMID:29891944]"}
{"concept_id": "C5380222", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of ciliary planar beating movement pattern", "definition": "Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement. [GOC:krc, PMID:26506310]"}
{"concept_id": "C5380223", "aliases": [], "types": ["T040"], "canonical_name": "regulation of blastocyst development", "definition": "Any process that modulates the frequency, rate or extent of blastocyst development. [GOC:krc, PMID:29593216]"}
{"concept_id": "C5380224", "aliases": ["laryngeal morphogenesis"], "types": ["T042"], "canonical_name": "larynx morphogenesis", "definition": "The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration. [GOC:krc, PMID:28177282]"}
{"concept_id": "C5380225", "aliases": [], "types": ["T042"], "canonical_name": "larynx development", "definition": "The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration. [GOC:krc, PMID:28177282]"}
{"concept_id": "C5380227", "aliases": [], "types": ["T044"], "canonical_name": "cyclic-GMP-AMP transmembrane transporter activity", "definition": "Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other. [PMID:31126740]"}
{"concept_id": "C5380228", "aliases": [], "types": ["T043"], "canonical_name": "cyclic-GMP-AMP transmembrane import across plasma membrane", "definition": "The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol. [PMID:31126740]"}
{"concept_id": "C5380229", "aliases": ["GW-body"], "types": ["T026"], "definition": "A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs. [PMID:16418578, PMID:26930655, PMID:29576456]", "canonical_name": "GW body"}
{"concept_id": "C5380230", "aliases": ["BR-body"], "types": ["T026"], "canonical_name": "RNP body", "definition": "A ribonucleoprotein granule located in the cytoplasm of bacteria, minimally containing the RNase E protein and RNA molecules. Bacterial RNP-bodies are similar to eukaryotic P-bodies and stress granules. [PMID:30197298]"}
{"concept_id": "C5380231", "aliases": [], "types": ["T026"], "canonical_name": "galectin lattice", "definition": "A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids. [PMID:19021578, PMID:26092931, PMID:28893908, PMID:30951647]"}
{"concept_id": "C5380232", "aliases": [], "types": ["T040"], "canonical_name": "antibacterial innate immune response", "definition": "An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [PMID:16177355, PMID:23006328]"}
{"concept_id": "C5380233", "aliases": ["decoy receptor complex location"], "types": ["T026"], "canonical_name": "decoy receptor complex", "definition": "A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound. [GOC:bhm, PMID:30621730, PMID:9168977]"}
{"concept_id": "C5380234", "aliases": ["osteoprotegerin complex location"], "types": ["T026"], "canonical_name": "osteoprotegerin complex"}
{"concept_id": "C5380235", "aliases": ["histone H3 ubiquitylation"], "types": ["T044"], "canonical_name": "histone H3 ubiquitination", "definition": "The modification of histone H3 by the addition of one or more ubiquitin groups. [GOC:mah, PMID:31468675]"}
{"concept_id": "C5380236", "aliases": ["histone H3K14 ubiquitination", "histone H3 ubiquitination at K14", "histone H3-K14 ubiquitylation"], "types": ["T044"], "canonical_name": "histone H3-K14 ubiquitination", "definition": "The modification of histone H3 by the addition of one or more ubiquitin groups to a lysine residue at position 14 of the histone. [GOC:mah, PMID:31468675]"}
{"concept_id": "C5380237", "aliases": [], "types": ["T032"], "canonical_name": "antiviral innate immune response", "definition": "A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [PMID:31006531]"}
{"concept_id": "C5380238", "aliases": [], "types": ["T044"], "canonical_name": "immune receptor activity", "definition": "Receiving a signal and transmitting it in a cell to initiate an immune response. [PMID:31415752, Wikipedia:Immune_receptor]"}
{"concept_id": "C5380239", "aliases": [], "types": ["T044"], "canonical_name": "innate immune receptor activity", "definition": "Receiving a signal and transmitting it in a cell to initiate an innate immune response. [PMID:28921463, PMID:31415752]"}
{"concept_id": "C5380240", "aliases": [], "types": ["T044"], "canonical_name": "psilocybin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product. [PMID:28763571]"}
{"concept_id": "C5380241", "aliases": ["psilocybin synthase", "norbaeocystin methyltransferase"], "types": ["T044"], "canonical_name": "4-hydroxytryptamine 4-phosphate methyltransferase activity", "definition": "Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) <=> 2 S-adenosyl-L-homocysteine + psilocybin. [PMID:28763571]"}
{"concept_id": "C5380242", "aliases": [], "types": ["T044"], "canonical_name": "tryptamine 4-monooxygenase activity", "definition": "Catalysis of the reaction: tryptamine + reduced acceptor + O(2) <=> 4-hydroxytryptamine + acceptor + H(2)O. [PMID:28763571]"}
{"concept_id": "C5380243", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxytryptamine kinase activity", "definition": "Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+). [PMID:28763571]"}
{"concept_id": "C5380244", "aliases": [], "types": ["T044"], "canonical_name": "norsolorinic acid ketoreductase activity", "definition": "Catalysis of the reaction: (1'S)-averantin + NADP(+) <=> norsolorinic acid + NADPH. [PMID:10584035, PMID:8368836, RHEA:35447]"}
{"concept_id": "C5380245", "aliases": ["ATPase-coupled azole transmembrane transporter activity", "azole ABC transporter activity"], "types": ["T044"], "canonical_name": "ABC-type azole transporter activity", "definition": "Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out). [PMID:31501141, RHEA:33503]"}
{"concept_id": "C5380246", "aliases": [], "types": ["T044"], "canonical_name": "averantin hydroxylase activity", "definition": "Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O(2) <=> (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H(2)O. Involved in aflatoxin biosynthesis. [EC:1.14.14.116, PMID:8368836]"}
{"concept_id": "C5380247", "aliases": [], "types": ["T044"], "canonical_name": "5'-hydroxyaverantin dehydrogenase activity", "definition": "Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD(+) <=> 5'-oxoaverantin + NADH. [EC:1.1.1.352, PMID:14602595]"}
{"concept_id": "C5380248", "aliases": [], "types": ["T044"], "canonical_name": "versiconal hemiacetal acetate esterase activity", "definition": "Catalyzes the reactions: versiconal hemiacetal acetate + H(2)O <=> versiconal + acetate, as well as versiconol acetate + H(2)O <=> versiconol + acetate. [EC:3.1.1.94, PMID:15006741, PMID:15932995, PMID:8368837]"}
{"concept_id": "C5380249", "aliases": [], "types": ["T044"], "canonical_name": "versicolorin B desaturase activity", "definition": "Catalyzes the reaction: versicolorin B + NADPH + O(2) <=> versicolorin A + NADP(+) + 2 H(2)O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. [PMID:15006741, PMID:8368837]"}
{"concept_id": "C5380250", "aliases": [], "types": ["T044"], "canonical_name": "aflatoxin B synthase activity", "definition": "Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) <=> aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H(2)O + methanol + CO(2). Produces both aflatoxin B(1) and aflatoxin B(2). [EC:1.14.14.117]"}
{"concept_id": "C5380251", "aliases": ["effector triggered suppression of host immune innate response by symbiont", "effector-mediated suppression of host innate immunity", "effector-triggered suppression of host immune innate response by symbiont", "effector-dependent suppression of host immune innate response by symbiont", "effector dependent suppression of host immune innate response by symbiont", "effector-mediated suppression of host immune innate response by symbiont", "effector-mediated suppression of host innate immune response by symbiont"], "types": ["T040"], "canonical_name": "effector-mediated suppression of host innate immune response", "definition": "A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:21467214, PMID:30584105]"}
{"concept_id": "C5380252", "aliases": ["effector mediated modulation of host immune response by symbiont", "effector-mediated modulation of host immunity", "effector-triggered modulation of host immune response by symbiont", "effector triggered modulation of host immune response by symbiont", "effector-dependent modulation of host immune response by symbiont"], "types": ["T040"], "canonical_name": "effector-mediated modulation of host innate immune response by symbiont", "definition": "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:21467214]"}
{"concept_id": "C5380253", "aliases": [], "types": ["T043"], "canonical_name": "spindle pole body-led chromosome movement during mitotic interphase", "definition": "A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase. [PMID:31483748]"}
{"concept_id": "C5380254", "aliases": [], "types": ["T043"], "canonical_name": "L-alanine export across the plasma membrane", "definition": "The directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region. [PMID:26073055, PMID:31591285]"}
{"concept_id": "C5380255", "aliases": [], "types": ["T044"], "canonical_name": "L-alanine:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out). [PMID:26073055, PMID:31591285]"}
{"concept_id": "C5380256", "aliases": [], "types": ["T045"], "canonical_name": "regulation of mRNA alternative polyadenylation", "definition": "Any process that modulates the frequency, rate or extent of mRNA alternative polyadenylation. [PMID:29507755]"}
{"concept_id": "C5380257", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mRNA alternative polyadenylation", "definition": "Any process that activates or increases the frequency, rate or extent of mRNA alternative polyadenylation. [PMID:29507755]"}
{"concept_id": "C5380258", "aliases": [], "types": ["T044"], "canonical_name": "solute:bicarbonate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + HCO3-(out) = solute(in) + HCO3-(in). [PMID:27166256]"}
{"concept_id": "C5380259", "aliases": [], "types": ["T044"], "canonical_name": "zinc:bicarbonate symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in). [PMID:27166256]"}
{"concept_id": "C5380260", "aliases": [], "types": ["T044"], "canonical_name": "zinc:bicarbonate:selenite symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out). [PMID:27166256]"}
{"concept_id": "C5380261", "aliases": ["carrier protein activity"], "types": ["T044"], "canonical_name": "phosphopantetheine-dependent carrier activity", "definition": "Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate. [PMID:17502372]"}
{"concept_id": "C5380262", "aliases": [], "types": ["T040"], "canonical_name": "effector-mediated modulation of host defenses by symbiont", "definition": "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:30610168]"}
{"concept_id": "C5380263", "aliases": [], "types": ["T044"], "canonical_name": "DNA-binding transcription factor inhibitor activity"}
{"concept_id": "C5380264", "aliases": [], "types": ["T044"], "canonical_name": "ATP-sensitive calcium-release channel activity", "definition": "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts. [PMID:22736763]"}
{"concept_id": "C5380265", "aliases": ["effector mediated modulation of host process by symbiont", "effector triggered modulation of host process by symbiont", "effector-dependent modulation of host process by symbiont"], "types": ["T040"], "canonical_name": "effector-mediated modulation of host process by symbiont", "definition": "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:21467214]"}
{"concept_id": "C5380266", "aliases": [], "types": ["T043"], "canonical_name": "heme import into cell", "definition": "The directed movement of a heme from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. [PMID:28193844]"}
{"concept_id": "C5380267", "aliases": ["heme assimilation"], "types": ["T043"], "canonical_name": "heme assimilation"}
{"concept_id": "C5380268", "aliases": [], "types": ["T043"], "canonical_name": "endocytic heme import into cell", "definition": "The directed movement into cell of externally available heme by receptor-mediated endocytosis. [PMID:28193844]"}
{"concept_id": "C5380269", "aliases": ["effector-mediated suppression of pattern-triggered immunity signaling", "effector-mediated suppression of PTI signalling"], "types": ["T040"], "canonical_name": "effector-mediated suppression of host pattern-triggered immunity signaling", "definition": "A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants. [PMID:30584105]"}
{"concept_id": "C5380270", "aliases": [], "types": ["T040"], "canonical_name": "effector-mediated suppression of host pattern recognition receptor signaling"}
{"concept_id": "C5380271", "aliases": ["effector-mediated suppression of host PRR signalling"], "types": ["T040"], "canonical_name": "effector-mediated suppression of host PRR signaling"}
{"concept_id": "C5380272", "aliases": [], "types": ["T043"], "canonical_name": "galactose import across plasma membrane", "definition": "The directed movement of galactose from outside of a cell, across the plasma membrane and into the cytosol. [PMID:23254763]"}
{"concept_id": "C5380273", "aliases": ["pathogen-associated molecular pattern signalling", "PTI signalling", "MAMP-triggered immunity signalling"], "types": ["T044"], "canonical_name": "PAMP-triggered immunity signalling pathway", "definition": "The series of molecular signals initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. [PMID:25744358]"}
{"concept_id": "C5380274", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of mitotic sister chromatid biorientation", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536, PMID:20739936, PMID:21306900]"}
{"concept_id": "C5380275", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of chromosome passenger complex localization to kinetochore", "definition": "Any process that activates or increases the frequency, rate or extent of a chromosome passenger complex localization to kinetochore. [PMID:20739936]"}
{"concept_id": "C5380276", "aliases": ["DNA-(apurinic site/apyrimidinic site) binding", "DNA AP site binding"], "types": ["T045"], "canonical_name": "DNA-(abasic site) binding", "definition": "Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base. [PMID:23245849]"}
{"concept_id": "C5380277", "aliases": [], "types": ["T045"], "canonical_name": "DNA-(apurinic site) binding"}
{"concept_id": "C5380278", "aliases": [], "types": ["T045"], "canonical_name": "DNA-(apyrimidinic site) binding"}
{"concept_id": "C5380279", "aliases": [], "types": ["T045"], "canonical_name": "5'-hydroxyl dinucleotide hydrolase", "definition": "Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA. [PMID:31777937]"}
{"concept_id": "C5380280", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein localization to meiotic spindle pole body", "definition": "Any process that modulates the frequency, rate or extent of protein localization to a meiotic spindle pole body. [PMID:22438582]"}
{"concept_id": "C5380281", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein localization to meiotic spindle pole body", "definition": "Any process that increases the frequency, rate or extent of protein localization to a meiotic spindle pole body. [PMID:22438582]"}
{"concept_id": "C5380282", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of protein localization to meiotic spindle pole body", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a meiotic spindle pole body. [PMID:22438582]"}
{"concept_id": "C5380283", "aliases": [], "types": ["T044"], "canonical_name": "protein stearoylation", "definition": "The covalent attachment of a stearoyl group to an amino acid in a protein. [PMID:26214738]"}
{"concept_id": "C5380284", "aliases": [], "types": ["T044"], "canonical_name": "protein-cysteine S-stearoyltransferase activity", "definition": "Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]. [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59740]"}
{"concept_id": "C5380285", "aliases": [], "types": ["T044"], "canonical_name": "protein-cysteine S-oleoyltransferase activity", "definition": "Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]. [PMID:22247542, RHEA:59744]"}
{"concept_id": "C5380286", "aliases": [], "types": ["T044"], "canonical_name": "protein-cysteine S-arachidonoyltransferase activity", "definition": "Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]. [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59748]"}
{"concept_id": "C5380287", "aliases": [], "types": ["T044"], "canonical_name": "peroxide sensor activity", "definition": "Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule. [PMID:20919928]"}
{"concept_id": "C5380288", "aliases": ["mitochondrion plasma membrane tether activity", "plasma membrane-mitochondrion tether activity", "mitochondrion plasma membrane adaptor activity", "plasma membrane-mitochondrion adaptor activity"], "types": ["T044"], "canonical_name": "mitochondrion-plasma membrane adaptor activity", "definition": "The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion. [PMID:31582398]"}
{"concept_id": "C5380289", "aliases": ["cytoskeletal protein-nuclear membrane adaptor activity", "cytoskeleton nuclear membrane anchor activity", "nuclear membrane-cytoskeleton anchor activity", "cytoskeletal protein-nuclear membrane anchor activity"], "types": ["T044"], "canonical_name": "cytoskeleton-nuclear membrane anchor activity", "definition": "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane. [PMID:16237665]"}
{"concept_id": "C5380290", "aliases": [], "types": ["T026"], "canonical_name": "chromosome, telomeric repeat region", "definition": "A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop. [PMID:11352055, PMID:30208292]"}
{"concept_id": "C5380291", "aliases": ["fumigermin biosynthesis", "fumigermin formation", "fumigermin anabolism", "fumigermin synthesis"], "types": ["T044"], "canonical_name": "fumigermin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumigermin, an alpha-pyrone secondary metabolite found in some species of fungi such as Aspergillus fumigatus. [PMID:32083553]"}
{"concept_id": "C5380292", "aliases": [], "types": ["T043"], "canonical_name": "cytokine precursor processing", "definition": "The cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine. [PMID:29247995]"}
{"concept_id": "C5380293", "aliases": [], "types": ["T043"], "canonical_name": "signaling receptor ligand precursor processing", "definition": "The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand. [PMID:29247995]"}
{"concept_id": "C5380294", "aliases": ["centromere nuclear envelope anchor activity", "chromosome, centromeric region-nuclear envelope anchor activity", "nuclear envelope-centromere anchor activity", "centromere-inner nuclear envelope anchor activity", "centromere nuclear envelope tether activity", "nuclear envelope-centromere tether activity", "centromere-inner nuclear envelope tether activity"], "types": ["T044"], "canonical_name": "centromere-nuclear envelope anchor activity", "definition": "The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location. [PMID:31635174]"}
{"concept_id": "C5380295", "aliases": [], "types": ["T043"], "canonical_name": "protein targeting to Golgi apparatus", "definition": "The process of targeting specific proteins to the Golgi apparatus. Usually requires an organelle-specific protein sequence motif or a protein modification (for example a palmitoylation). [PMID:18817523]"}
{"concept_id": "C5380296", "aliases": ["counting factor complex location"], "types": ["T026"], "canonical_name": "counting factor complex", "definition": "A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum. [PMID:10444594, PMID:12117815, PMID:12912898, PMID:16963635, PMID:18426773]"}
{"concept_id": "C5380297", "aliases": ["protein aggregate center formation", "PAC assembly", "protein aggregate centre assembly"], "types": ["T043"], "canonical_name": "protein aggregate center assembly", "definition": "The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. [PMID:32075773]"}
{"concept_id": "C5380298", "aliases": [], "types": ["T044"], "canonical_name": "cytoplasm protein quality control", "definition": "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. [PMID:32075773]"}
{"concept_id": "C5380299", "aliases": ["meiotic spindle pole body duplication", "initial spindle pole body separation involved in meiosis I"], "types": ["T043"], "canonical_name": "initial meiotic spindle pole body separation", "definition": "The release of duplicated meiotic spindle pole bodies (SPBs). [PMID:31532702]"}
{"concept_id": "C5380300", "aliases": [], "types": ["T044"], "canonical_name": "protein demethylase activity", "definition": "Catalysis of the removal of a methyl group from a protein. [PMID:24498420, PMID:28360925]"}
{"concept_id": "C5380301", "aliases": [], "types": ["T045"], "canonical_name": "pre-transcriptional gene silencing by RNA", "definition": "Any gene inactivation (silencing) process mediated by small RNA molecules that occur before the trancription begins. [PMID:21420348]"}
{"concept_id": "C5380302", "aliases": [], "types": ["T040"], "canonical_name": "response to Gram-positive bacterium", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium. [PMID:23664307]"}
{"concept_id": "C5380303", "aliases": [], "types": ["T040"], "canonical_name": "response to Gram-negative bacterium", "definition": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-negative bacterium. [PMID:23664307]"}
{"concept_id": "C5380304", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to cell-cell junction", "definition": "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. [GOC:aruk, GOC:bc, PMID:26706435]"}
{"concept_id": "C5380305", "aliases": [], "types": ["T043"], "canonical_name": "regulation of protein localization to cell-cell junction", "definition": "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction. [GOC:aruk, GOC:bc, PMID:26706435]"}
{"concept_id": "C5380306", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of protein localization to cell-cell junction", "definition": "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction. [GOC:aruk, GOC:bc, PMID:26706435]"}
{"concept_id": "C5380307", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of cholesterol esterification", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol esterification. [GOC:aruk, GOC:bc, PMID:21810484, PMID:24201375]"}
{"concept_id": "C5380308", "aliases": [], "types": ["T043"], "canonical_name": "regulation of transepithelial transport", "definition": "Any process that modulates the frequency, rate or extent of transepithelial transport. [GOC:aruk, PMID:27593915]"}
{"concept_id": "C5380312", "aliases": [], "types": ["T043"], "canonical_name": "cell-substrate junction organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix. [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]"}
{"concept_id": "C5380313", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell-substrate junction organization", "definition": "Any process that modulates the frequency, rate or extent of cell-substrate junction organization. [GOC:aruk]"}
{"concept_id": "C5380314", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell-substrate junction organization", "definition": "Any process that activates or increases the frequency, rate or extent of cell-substrate junction organization. [GOC:aruk]"}
{"concept_id": "C5380315", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell-substrate junction organization", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization. [GOC:aruk]"}
{"concept_id": "C5380316", "aliases": ["negative regulation of protein localisation to cell-cell junction"], "types": ["T043"], "canonical_name": "negative regulation of protein localization to cell-cell junction", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction. [GOC:aruk, GOC:bc]"}
{"concept_id": "C5380324", "aliases": [], "types": ["T043"], "canonical_name": "regulation of interleukin-33 production", "definition": "Any process that modulates the frequency, rate or extent of interleukin-33 production. [GOC:aruk, PMID:29778524]"}
{"concept_id": "C5380325", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of interleukin-33 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 production. [GOC:aruk, PMID:29778524]"}
{"concept_id": "C5380326", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of interleukin-33 production", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-33 production. [GOC:aruk]"}
{"concept_id": "C5380333", "aliases": [], "types": ["T043"], "canonical_name": "regulation of interleukin-37 biosynthetic process"}
{"concept_id": "C5380334", "aliases": [], "types": ["T044"], "canonical_name": "interleukin-37 biosynthetic process"}
{"concept_id": "C5380335", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of interleukin-37 biosynthetic process"}
{"concept_id": "C5380336", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of interleukin-37 biosynthetic process"}
{"concept_id": "C5380337", "aliases": ["regulation of CD86 biosynthetic process"], "types": ["T043"], "canonical_name": "regulation of CD86 production", "definition": "Any process that modulates the frequency, rate or extent of CD86 biosynthetic process. [GOC:aruk, PMID:26936882]"}
{"concept_id": "C5380338", "aliases": ["negative regulation of CD86 biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of CD86 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process. [GOC:aruk, PMID:26936882]"}
{"concept_id": "C5380339", "aliases": ["positive regulation of CD86 biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of CD86 production", "definition": "Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process. [GOC:aruk]"}
{"concept_id": "C5380340", "aliases": ["regulation of CD80 biosynthetic process"], "types": ["T043"], "canonical_name": "regulation of CD80 production", "definition": "Any process that modulates the frequency, rate or extent of CD80 biosynthetic process. [GOC:aruk, PMID:26936882]"}
{"concept_id": "C5380341", "aliases": ["negative regulation of CD80 biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of CD80 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process. [GOC:aruk, PMID:26936882]"}
{"concept_id": "C5380342", "aliases": ["positive regulation of CD80 biosynthetic process"], "types": ["T043"], "canonical_name": "positive regulation of CD80 production", "definition": "Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process. [GOC:aruk]"}
{"concept_id": "C5380343", "aliases": [], "types": ["T043"], "canonical_name": "cell junction disassembly", "definition": "The disaggregation of a cell junction into its constituent components. [GOC:aruk, PMID:25490267]"}
{"concept_id": "C5380344", "aliases": [], "types": ["T043"], "canonical_name": "cell-cell junction disassembly", "definition": "The disaggregation of a cell-cell junction into its constituent components. [GOC:aruk, PMID:25490267]"}
{"concept_id": "C5380348", "aliases": [], "types": ["T043"], "canonical_name": "regulation of interleukin-17A biosynthetic process"}
{"concept_id": "C5380349", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of interleukin-17A biosynthetic process"}
{"concept_id": "C5380350", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of interleukin-17A biosynthetic process"}
{"concept_id": "C5380352", "aliases": [], "types": ["T043"], "canonical_name": "interleukin-34 production", "definition": "The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:aruk, PMID:26754294]"}
{"concept_id": "C5380354", "aliases": [], "types": ["T043"], "canonical_name": "regulation of interleukin-34 production", "definition": "Any process that modulates the frequency, rate or extent of interleukin-34 production. [GOC:aruk, PMID:26754294]"}
{"concept_id": "C5380355", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of interleukin-34 production", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-34 production. [GOC:aruk]"}
{"concept_id": "C5380356", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of interleukin-34 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production. [GOC:aruk, PMID:26754294]"}
{"concept_id": "C5380360", "aliases": [], "types": ["T045"], "canonical_name": "miRNA-mediated activation of transcription by RNA polymerase II", "definition": "Any process mediated by a microRNA (miRNA) that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:aruk, PMID:20737563, PMID:27145859]"}
{"concept_id": "C5380361", "aliases": [], "types": ["T045"], "canonical_name": "miRNA-mediated regulation of transcription by RNA polymerase II", "definition": "Any process mediated by a microRNA (miRNA) that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:aruk, PMID:20737563, PMID:27145859]"}
{"concept_id": "C5380362", "aliases": [], "types": ["T045"], "canonical_name": "miRNA-mediated inhibition of transcription by RNA polymerase II", "definition": "Any process mediated by a microRNA (miRNA) that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:aruk]"}
{"concept_id": "C5380363", "aliases": [], "types": ["T044"], "canonical_name": "regulation of histone H3-K4 acetylation", "definition": "Any process that modulates the frequency, rate or extent of histone H3-K4 acetylation. [GOC:aruk]"}
{"concept_id": "C5380364", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of histone H3-K4 acetylation", "definition": "Any process that activates or increases the frequency, rate or extent of histone H3-K4 acetylation. [GOC:aruk, PMID:20737563]"}
{"concept_id": "C5380365", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of histone H3-K4 acetylation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 acetylation. [GOC:aruk]"}
{"concept_id": "C5380369", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphatidylcholine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]"}
{"concept_id": "C5380370", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phosphatidylcholine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]"}
{"concept_id": "C5380371", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphatidylcholine metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]"}
{"concept_id": "C5380372", "aliases": [], "types": ["T043"], "canonical_name": "regulation of phosphatidylethanolamine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylethanolamine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]"}
{"concept_id": "C5380373", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of phosphatidylethanolamine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylethanolamine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]"}
{"concept_id": "C5380374", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphatidylethanolamine metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylethanolamine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]"}
{"concept_id": "C5380375", "aliases": [], "types": ["T044"], "canonical_name": "regulation of phosphatidylserine metabolic process", "definition": "Any process that modulates the frequency, rate or extent of phosphatidylserine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]"}
{"concept_id": "C5380376", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of phosphatidylserine metabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of phosphatidylserine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]"}
{"concept_id": "C5380377", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of phosphatidylserine metabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]"}
{"concept_id": "C5380379", "aliases": [], "types": ["T043"], "canonical_name": "regulation of interleukin-32 biosynthetic process"}
{"concept_id": "C5380380", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of interleukin-32 biosynthetic process"}
{"concept_id": "C5380381", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of interleukin-32 biosynthetic process"}
{"concept_id": "C5380385", "aliases": ["transport across BCSFB", "transport across blood-CSF barrier", "transport across blood/cerebrospinal fluid barrier", "transport across blood/CSF barrier"], "types": ["T043"], "canonical_name": "transport across blood-cerebrospinal fluid barrier", "definition": "The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-cerebrospinal fluid barrier. [GOC:aruk, GOC:bc, PMID:21349151]"}
{"concept_id": "C5380386", "aliases": [], "types": ["T039"], "canonical_name": "regulation of transport across blood-brain barrier", "definition": "Any process that modulates the frequency, rate or extent of transport across the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653]"}
{"concept_id": "C5380387", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of transport across blood-brain barrier", "definition": "Any process that activates or increases the frequency, rate or extent of transport across blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653]"}
{"concept_id": "C5380388", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of transport across blood-brain barrier", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of transport across blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653]"}
{"concept_id": "C5380395", "aliases": ["establishment and maintenance of spindle pole body localization"], "types": ["T043"], "canonical_name": "mitotic spindle pole body localization", "definition": "A process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location. [PMID:24963130]"}
{"concept_id": "C5380396", "aliases": ["establishment of spindle pole body localisation"], "types": ["T043"], "canonical_name": "establishment of spindle pole body localization"}
{"concept_id": "C5380397", "aliases": [], "types": ["T043"], "canonical_name": "spindle pole body docking"}
{"concept_id": "C5380398", "aliases": [], "types": ["T043"], "canonical_name": "spindle pole body positioning"}
{"concept_id": "C5380400", "aliases": ["positive regulation of ribosomal DNA heterochromatin assembly"], "types": ["T045"], "canonical_name": "positive regulation of rDNA heterochromatin assembly", "definition": "Any process that activates or increases the frequency, rate or extent of assembly of rDNA heterochromatin. [PMID:10899127]"}
{"concept_id": "C5380401", "aliases": [], "types": ["T044"], "canonical_name": "pantothenate anabolism from valine"}
{"concept_id": "C5380402", "aliases": [], "types": ["T026"], "canonical_name": "TIS granule", "definition": "A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER). [PMID:30449617, PMID:30479375, Wikipedia:TIGER_domain]"}
{"concept_id": "C5380403", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of L-glutamine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine biosynthesis. [GOC:ha, PMID:19755423]"}
{"concept_id": "C5380404", "aliases": [], "types": ["T043"], "canonical_name": "pseudohyphal septin ring assembly", "definition": "The aggregation, arrangement and bonding together of septins and associated proteins to form a tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection. [PMID:29567712]"}
{"concept_id": "C5380405", "aliases": [], "types": ["T026"], "canonical_name": "cellular anatomical entity", "definition": "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. [GOC:kmv]"}
{"concept_id": "C5380406", "aliases": [], "types": ["T044"], "canonical_name": "pathogen associated molecular pattern receptor activity"}
{"concept_id": "C5441707", "aliases": [], "types": ["T026"], "definition": "An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes. [NIF_Subcellular:sao1863852493]", "canonical_name": "glial filament"}
{"concept_id": "C5442003", "aliases": [], "types": ["T044"], "canonical_name": "ubiquitinyl hydrolase 1 activity"}
{"concept_id": "C5442023", "aliases": ["cytoplasmic mRNP granule", "stress granule"], "types": ["T026"], "definition": "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]", "canonical_name": "cytoplasmic stress granule"}
{"concept_id": "C5444010", "aliases": [], "types": ["T044"], "canonical_name": "fatty acid desaturase"}
{"concept_id": "C5444011", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:krc, RHEA:39023]", "canonical_name": "fatty acid omega-hydroxylase activity"}
{"concept_id": "C5444122", "aliases": [], "types": ["T044"], "canonical_name": "hephaestin"}
{"concept_id": "C5444238", "aliases": ["MIM complex location", "mitochondrial outer import machinery"], "types": ["T026"], "definition": "A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. MIM constitutes the major integration site for alpha-helical embedded proteins. In yeast, consists oof Mim1 and Mim2. [PMID:19944477, PMID:22467864, PMID:33035511]", "canonical_name": "MIM complex"}
{"concept_id": "C5444239", "aliases": [], "types": ["T044"], "canonical_name": "respiratory complex II"}
{"concept_id": "C5444408", "aliases": ["nucleolar ring"], "types": ["T026"], "definition": "Ring-like structures located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress. [PMID:33176152]", "canonical_name": "NuRs"}
{"concept_id": "C5444559", "aliases": ["pellicular plasma membrane", "pellicle membrane"], "types": ["T026"], "definition": "The portion of the plasma membrane surrounding the pellicle, a structure enclosing some parasite cells such as certain apicomplexa and Euglenozoa. These membranes are associated with an infrastructure of microtubules, microfilaments, and other organelles. [GOC:ach, GOC:krc, PMID:18095354, PMID:30550896, PMID:6993644, PMID:7175771]", "canonical_name": "pellicular membrane"}
{"concept_id": "C5444564", "aliases": ["translocase of the outer mitochondrial membrane", "TOM complex"], "types": ["T026"], "definition": "A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane. [PMID:33035511]", "canonical_name": "TOM complex location"}
{"concept_id": "C5444849", "aliases": ["ATP-dependent citrate lyase complex location", "citrate lyase complex", "citrate lyase complex location"], "types": ["T026"], "definition": "A protein complex that catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA. [PMID:12376641]", "canonical_name": "ATP-dependent citrate lyase complex"}
{"concept_id": "C5445058", "aliases": ["integrated stress response signaling"], "types": ["T043"], "definition": "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. [PMID:27629041]", "canonical_name": "ISR"}
{"concept_id": "C5445059", "aliases": ["DynAP"], "types": ["T026"], "definition": "An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm. [GOC:krc, PMID:30561330, PMID:32898505, PMID:33263282]", "canonical_name": "dynein axonemal particle"}
{"concept_id": "C5445275", "aliases": [], "types": ["T044"], "definition": "Catalysis of the reaction: NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide. [RHEA:63180]", "canonical_name": "superoxide-generating NADPH oxidase activity"}
{"concept_id": "C5445276", "aliases": ["ARE binding"], "types": ["T045"], "canonical_name": "AU-rich element binding"}
{"concept_id": "C5450307", "aliases": [], "types": ["T043"], "canonical_name": "microtubule sliding involved in mitotic spindle elongation"}
{"concept_id": "C5450308", "aliases": [], "types": ["T044"], "canonical_name": "fatty-acyl binding"}
{"concept_id": "C5450309", "aliases": [], "types": ["T043"], "canonical_name": "co-flocculation"}
{"concept_id": "C5450310", "aliases": [], "types": ["T043"], "canonical_name": "coflocculation"}
{"concept_id": "C5450311", "aliases": [], "types": ["T043"], "canonical_name": "coflocculation via lectin-mannose interaction"}
{"concept_id": "C5450312", "aliases": [], "types": ["T043"], "canonical_name": "coflocculation via protein-carbohydrate interaction"}
{"concept_id": "C5450313", "aliases": ["RecA-family recombinase activity"], "types": ["T045"], "canonical_name": "RecA-family recombinase activity"}
{"concept_id": "C5450314", "aliases": [], "types": ["T045"], "canonical_name": "strand exchange activity"}
{"concept_id": "C5450315", "aliases": [], "types": ["T026"], "canonical_name": "PP2a-protector"}
{"concept_id": "C5450316", "aliases": [], "types": ["T044"], "canonical_name": "activation of MAPK activity involved in osmosensory signaling pathway"}
{"concept_id": "C5450317", "aliases": [], "types": ["T044"], "canonical_name": "activation of MAPKK activity during osmolarity sensing"}
{"concept_id": "C5450318", "aliases": [], "types": ["T044"], "canonical_name": "activation of MAPKK activity involved in osmosensory signaling pathway"}
{"concept_id": "C5450319", "aliases": [], "types": ["T044"], "canonical_name": "activation of MAPKKK activity during osmolarity sensing"}
{"concept_id": "C5450320", "aliases": [], "types": ["T043"], "canonical_name": "activation of MAPKKK activity involved in osmosensory signaling pathway"}
{"concept_id": "C5450321", "aliases": [], "types": ["T044"], "canonical_name": "activation of Pbs2 kinase"}
{"concept_id": "C5450322", "aliases": [], "types": ["T043"], "canonical_name": "inactivation of MAPK activity involved in osmosensory signaling pathway"}
{"concept_id": "C5450323", "aliases": [], "types": ["T044"], "canonical_name": "osmolarity sensing, activation of MAP kinase kinase activity"}
{"concept_id": "C5450324", "aliases": [], "types": ["T044"], "canonical_name": "osmolarity sensing, activation of MAP kinase kinase kinase activity"}
{"concept_id": "C5450325", "aliases": [], "types": ["T043"], "canonical_name": "osmolarity sensing, activation of MAPK activity"}
{"concept_id": "C5450326", "aliases": [], "types": ["T044"], "canonical_name": "osmolarity sensing, activation of MAPKK activity"}
{"concept_id": "C5450327", "aliases": [], "types": ["T043"], "canonical_name": "osmolarity sensing, activation of MAPKKK activity"}
{"concept_id": "C5450328", "aliases": [], "types": ["T044"], "canonical_name": "termination of MAPK activity during osmolarity sensing"}
{"concept_id": "C5450329", "aliases": ["threonyl-carbamoly transferase complex", "threonyl-carbamoly transferase complex location"], "types": ["T026"], "canonical_name": "TCTC"}
{"concept_id": "C5450330", "aliases": [], "types": ["T045"], "canonical_name": "box C/D sRNA 3'-end processing"}
{"concept_id": "C5450331", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA sRNA 3'-end processing"}
{"concept_id": "C5450332", "aliases": [], "types": ["T026"], "canonical_name": "condensed nuclear chromosome, centromeric region"}
{"concept_id": "C5450333", "aliases": [], "types": ["T026"], "canonical_name": "nuclear chromosome, telomere"}
{"concept_id": "C5450334", "aliases": [], "types": ["T026"], "canonical_name": "nuclear chromosome, telomeric region"}
{"concept_id": "C5450335", "aliases": ["8S condensin complex location"], "types": ["T026"], "canonical_name": "8S condensin complex"}
{"concept_id": "C5450336", "aliases": [], "types": ["T026"], "canonical_name": "condensin core heterodimer"}
{"concept_id": "C5450337", "aliases": ["condensin I complex location"], "types": ["T026"], "canonical_name": "condensin I complex"}
{"concept_id": "C5450338", "aliases": ["Smc2-Smc4 complex location"], "types": ["T026"], "canonical_name": "Smc2-Smc4 complex"}
{"concept_id": "C5450339", "aliases": ["gamma-tubulin large complex location, centrosomal"], "types": ["T026"], "canonical_name": "gamma-tubulin large complex, centrosomal"}
{"concept_id": "C5450340", "aliases": ["gamma-tubulin large complex location, eMTOC"], "types": ["T026"], "canonical_name": "gamma-tubulin large complex, eMTOC"}
{"concept_id": "C5450341", "aliases": ["gamma-tubulin large complex, equatorial microtubule organizing centre", "gamma-tubulin large complex location, equatorial microtubule organizing centre", "gamma-tubulin large complex location, equatorial microtubule organizing center"], "types": ["T026"], "canonical_name": "gamma-tubulin large complex, equatorial microtubule organizing center"}
{"concept_id": "C5450342", "aliases": ["gamma-tubulin large complex location, iMTOC"], "types": ["T026"], "canonical_name": "gamma-tubulin large complex, iMTOC"}
{"concept_id": "C5450343", "aliases": ["gamma-tubulin large complex location, interphase microtubule organizing center", "gamma-tubulin large complex location, interphase microtubule organizing centre", "gamma-tubulin large complex, interphase microtubule organizing centre"], "types": ["T026"], "canonical_name": "gamma-tubulin large complex, interphase microtubule organizing center"}
{"concept_id": "C5450344", "aliases": ["gamma-tubulin large complex location, mitotic spindle pole body"], "types": ["T026"], "canonical_name": "gamma-tubulin large complex, mitotic spindle pole body"}
{"concept_id": "C5450345", "aliases": ["gamma-tubulin large complex location, spindle pole body"], "types": ["T026"], "canonical_name": "gamma-tubulin large complex, spindle pole body"}
{"concept_id": "C5450346", "aliases": ["gamma-tubulin ring complex location, centrosomal"], "types": ["T026"], "canonical_name": "gamma-tubulin ring complex, centrosomal"}
{"concept_id": "C5450347", "aliases": [], "types": ["T026"], "canonical_name": "cell septum surface"}
{"concept_id": "C5450348", "aliases": [], "types": ["T026"], "canonical_name": "septum surface"}
{"concept_id": "C5450349", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase termination site sequence-specific DNA binding"}
{"concept_id": "C5450350", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial RNA polymerase termination site sequence-specific DNA binding"}
{"concept_id": "C5450351", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity"}
{"concept_id": "C5450352", "aliases": [], "types": ["T045"], "canonical_name": "transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding"}
{"concept_id": "C5450353", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription cofactor binding"}
{"concept_id": "C5450354", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription coregulator binding"}
{"concept_id": "C5450355", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription corepressor binding"}
{"concept_id": "C5450356", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription coactivator binding"}
{"concept_id": "C5450357", "aliases": [], "types": ["T040"], "canonical_name": "cytokine biosynthetic process"}
{"concept_id": "C5450358", "aliases": [], "types": ["T040"], "canonical_name": "cytokine metabolic process"}
{"concept_id": "C5450359", "aliases": [], "types": ["T040"], "canonical_name": "cytokine secretion"}
{"concept_id": "C5450360", "aliases": [], "types": ["T040"], "canonical_name": "interferon secretion"}
{"concept_id": "C5450361", "aliases": [], "types": ["T040"], "canonical_name": "interleukin secretion"}
{"concept_id": "C5450362", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cytokine biosynthetic process"}
{"concept_id": "C5450363", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cytokine secretion"}
{"concept_id": "C5450364", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of cytokine biosynthetic process"}
{"concept_id": "C5450365", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cytokine biosynthetic process"}
{"concept_id": "C5450366", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cytokine secretion"}
{"concept_id": "C5450367", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of cytokine biosynthetic process"}
{"concept_id": "C5450368", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of cytokine secretion"}
{"concept_id": "C5450369", "aliases": [], "types": ["T040"], "canonical_name": "cytokine biosynthetic process involved in immune response"}
{"concept_id": "C5450370", "aliases": [], "types": ["T040"], "canonical_name": "cytokine secretion during immune response"}
{"concept_id": "C5450371", "aliases": [], "types": ["T040"], "canonical_name": "cytokine secretion involved in immune response"}
{"concept_id": "C5450372", "aliases": [], "types": ["T038"], "canonical_name": "immunoglobulin biosynthetic process"}
{"concept_id": "C5450373", "aliases": [], "types": ["T040"], "canonical_name": "immunoglobulin secretion"}
{"concept_id": "C5450374", "aliases": [], "types": ["T039"], "canonical_name": "antibody secretion during immune response"}
{"concept_id": "C5450375", "aliases": [], "types": ["T039"], "canonical_name": "immunoglobulin biosynthetic process involved in immune response"}
{"concept_id": "C5450376", "aliases": [], "types": ["T039"], "canonical_name": "immunoglobulin secretion involved in immune response"}
{"concept_id": "C5450377", "aliases": [], "types": ["T042"], "canonical_name": "immune response in MALT"}
{"concept_id": "C5450378", "aliases": [], "types": ["T042"], "canonical_name": "immune response in mucosal-associated lymphoid tissue"}
{"concept_id": "C5450379", "aliases": [], "types": ["T042"], "canonical_name": "immune response in urogenital tract"}
{"concept_id": "C5450380", "aliases": [], "types": ["T040"], "canonical_name": "platelet activating factor production"}
{"concept_id": "C5450381", "aliases": [], "types": ["T040"], "canonical_name": "platelet activating factor secretion"}
{"concept_id": "C5450382", "aliases": [], "types": ["T040"], "canonical_name": "platelet activating factor secretion involved in acute inflammatory response"}
{"concept_id": "C5450383", "aliases": [], "types": ["T040"], "canonical_name": "platelet activating factor secretion involved in inflammatory response"}
{"concept_id": "C5450384", "aliases": [], "types": ["T043"], "canonical_name": "regulation of immunoglobulin biosynthetic process"}
{"concept_id": "C5450385", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of immunoglobulin biosynthetic process"}
{"concept_id": "C5450386", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of immunoglobulin secretion"}
{"concept_id": "C5450387", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of immunoglobulin biosynthetic process"}
{"concept_id": "C5450388", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of immunoglobulin secretion"}
{"concept_id": "C5450389", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cytokine biosynthetic process involved in immune response"}
{"concept_id": "C5450390", "aliases": [], "types": ["T040"], "canonical_name": "regulation of cytokine secretion involved in immune response"}
{"concept_id": "C5450391", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cytokine biosynthetic process involved in immune response"}
{"concept_id": "C5450392", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of cytokine secretion involved in immune response"}
{"concept_id": "C5450393", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of cytokine biosynthetic process involved in immune response"}
{"concept_id": "C5450394", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of cytokine secretion involved in immune response"}
{"concept_id": "C5450395", "aliases": ["defence response signaling pathway, resistance gene-dependent", "defence response signalling pathway, resistance gene-dependent", "defense response signalling pathway, resistance gene-dependent"], "types": ["T040"], "canonical_name": "defense response signaling pathway, resistance gene-dependent"}
{"concept_id": "C5450396", "aliases": [], "types": ["T040"], "canonical_name": "effector-triggered immune signaling"}
{"concept_id": "C5450397", "aliases": ["protein-DNA loading ATPase activity"], "types": ["T045"], "canonical_name": "DNA-protein loading ATPase activity"}
{"concept_id": "C5450398", "aliases": [], "types": ["T044"], "canonical_name": "alpha-ketoacid dehydrogenase activity"}
{"concept_id": "C5450399", "aliases": [], "types": ["T044"], "canonical_name": "large G-protein activity"}
{"concept_id": "C5450400", "aliases": [], "types": ["T044"], "canonical_name": "large G-protein GTPase activity"}
{"concept_id": "C5450401", "aliases": [], "types": ["T044"], "canonical_name": "small monomeric G protein activity"}
{"concept_id": "C5450402", "aliases": [], "types": ["T044"], "canonical_name": "L-serine dehydration activity"}
{"concept_id": "C5450403", "aliases": [], "types": ["T044"], "canonical_name": "acyl-CoA ligase activity"}
{"concept_id": "C5450404", "aliases": [], "types": ["T044"], "canonical_name": "magnesium-dependent protein serine/threonine phosphatase activity"}
{"concept_id": "C5450405", "aliases": [], "types": ["T044"], "canonical_name": "delta9-desaturase"}
{"concept_id": "C5450406", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-A-activated receptor activity"}
{"concept_id": "C5450407", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-B-activated receptor activity"}
{"concept_id": "C5450408", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-C-activated receptor activity"}
{"concept_id": "C5450409", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-D-activated receptor activity"}
{"concept_id": "C5450410", "aliases": [], "types": ["T044"], "canonical_name": "VEGF-E-activated receptor activity"}
{"concept_id": "C5450411", "aliases": [], "types": ["T044"], "canonical_name": "ARF guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450412", "aliases": [], "types": ["T044"], "canonical_name": "cAMP-dependent guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450413", "aliases": [], "types": ["T044"], "canonical_name": "Rab guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450414", "aliases": [], "types": ["T044"], "canonical_name": "Rac guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450415", "aliases": [], "types": ["T044"], "canonical_name": "Ral guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450416", "aliases": [], "types": ["T044"], "canonical_name": "Ran guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450417", "aliases": [], "types": ["T044"], "canonical_name": "Rap guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450418", "aliases": [], "types": ["T044"], "canonical_name": "Ras guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450419", "aliases": [], "types": ["T044"], "canonical_name": "Rho guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450420", "aliases": [], "types": ["T044"], "canonical_name": "Sar guanyl-nucleotide exchange factor activity"}
{"concept_id": "C5450421", "aliases": [], "types": ["T026"], "canonical_name": "nuclear centric heterochromatin"}
{"concept_id": "C5450422", "aliases": [], "types": ["T026"], "canonical_name": "nuclear cluster"}
{"concept_id": "C5450423", "aliases": [], "types": ["T026"], "canonical_name": "small ribonucleoprotein"}
{"concept_id": "C5450424", "aliases": ["small ribonucleoprotein protein complex location"], "types": ["T026"], "canonical_name": "small ribonucleoprotein protein complex"}
{"concept_id": "C5450425", "aliases": [], "types": ["T044"], "canonical_name": "trivalent inorganic cation transport"}
{"concept_id": "C5450426", "aliases": [], "types": ["T043"], "canonical_name": "local NEB"}
{"concept_id": "C5450427", "aliases": [], "types": ["T043"], "canonical_name": "nuclear envelope repair"}
{"concept_id": "C5450428", "aliases": [], "types": ["T043"], "canonical_name": "nuclear envelope resealing"}
{"concept_id": "C5450429", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in mitotic cell cycle G1/S checkpoint"}
{"concept_id": "C5450430", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in mitotic G2/M transition checkpoint"}
{"concept_id": "C5450431", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in Dma1-dependent checkpoint"}
{"concept_id": "C5450432", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in SAC-independent checkpoint"}
{"concept_id": "C5450433", "aliases": ["signalling cascade involved in Dma1-dependent checkpoint"], "types": ["T043"], "canonical_name": "signaling cascade involved in Dma1-dependent checkpoint"}
{"concept_id": "C5450434", "aliases": ["signalling cascade involved in SAC-independent checkpoint"], "types": ["T043"], "canonical_name": "signaling cascade involved in SAC-independent checkpoint"}
{"concept_id": "C5450435", "aliases": ["signalling pathway involved in Dma1-dependent checkpoint"], "types": ["T043"], "canonical_name": "signaling pathway involved in Dma1-dependent checkpoint"}
{"concept_id": "C5450436", "aliases": ["signalling pathway involved in SAC-independent checkpoint"], "types": ["T043"], "canonical_name": "signaling pathway involved in SAC-independent checkpoint"}
{"concept_id": "C5450437", "aliases": ["down-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint"], "types": ["T043"], "canonical_name": "down regulation of signal transduction involved in mitotic G2 DNA damage checkpoint"}
{"concept_id": "C5450438", "aliases": ["down-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint"], "types": ["T043"], "canonical_name": "down regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint"}
{"concept_id": "C5450439", "aliases": [], "types": ["T043"], "canonical_name": "G2 DNA damage checkpoint"}
{"concept_id": "C5450440", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of signal transduction involved in mitotic G2 DNA damage checkpoint"}
{"concept_id": "C5450441", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint"}
{"concept_id": "C5450442", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint"}
{"concept_id": "C5450443", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint"}
{"concept_id": "C5450444", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint"}
{"concept_id": "C5450445", "aliases": [], "types": ["T043"], "canonical_name": "regulation of signal transduction involved in mitotic G2 DNA damage checkpoint"}
{"concept_id": "C5450446", "aliases": [], "types": ["T043"], "canonical_name": "regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint"}
{"concept_id": "C5450447", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction by cis-phosphorylation"}
{"concept_id": "C5450448", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction by conformational transition"}
{"concept_id": "C5450449", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction by protein phosphorylation"}
{"concept_id": "C5450450", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction by trans-phosphorylation"}
{"concept_id": "C5450451", "aliases": [], "types": ["T045"], "canonical_name": "gene conversion at mating-type locus, DNA double-strand break formation"}
{"concept_id": "C5450452", "aliases": [], "types": ["T045"], "canonical_name": "gene conversion at mating-type locus, DNA double-strand break processing"}
{"concept_id": "C5450453", "aliases": [], "types": ["T045"], "canonical_name": "gene conversion at mating-type locus, DNA repair synthesis"}
{"concept_id": "C5450454", "aliases": [], "types": ["T045"], "canonical_name": "gene conversion at mating-type locus, termination of copy-synthesis"}
{"concept_id": "C5450455", "aliases": [], "types": ["T045"], "canonical_name": "heteroduplex formation involved in gene conversion at mating-type locus"}
{"concept_id": "C5450457", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome a3/copper complex"}
{"concept_id": "C5450458", "aliases": [], "types": ["T044"], "canonical_name": "electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity"}
{"concept_id": "C5450459", "aliases": [], "types": ["T044"], "canonical_name": "electron transporter, transferring electrons within cytochrome c oxidase complex activity"}
{"concept_id": "C5450461", "aliases": [], "types": ["T044"], "canonical_name": "peptidase activity, acting on D-amino acid peptides"}
{"concept_id": "C5450462", "aliases": [], "types": ["T044"], "canonical_name": "peptidase activity, acting on L-amino acid peptides"}
{"concept_id": "C5450463", "aliases": ["gamma-tubulin small complex location, centrosomal"], "types": ["T026"], "canonical_name": "gamma-tubulin small complex, centrosomal"}
{"concept_id": "C5450464", "aliases": ["gamma-tubulin small complex location, mitotic spindle pole body"], "types": ["T026"], "canonical_name": "gamma-tubulin small complex, mitotic spindle pole body"}
{"concept_id": "C5450465", "aliases": ["gamma-tubulin small complex location, spindle pole body"], "types": ["T026"], "canonical_name": "gamma-tubulin small complex, spindle pole body"}
{"concept_id": "C5450466", "aliases": ["Tub4 complex location"], "types": ["T026"], "canonical_name": "Tub4 complex"}
{"concept_id": "C5450467", "aliases": [], "types": ["T044"], "canonical_name": "sodium-dependent L-ascorbate transmembrane transporter activity"}
{"concept_id": "C5450468", "aliases": [], "types": ["T044"], "canonical_name": "D-serine dehydration activity"}
{"concept_id": "C5450469", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-adenosine triphosphate pyrophosphatase activity"}
{"concept_id": "C5450470", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-ATP pyrophosphatase activity"}
{"concept_id": "C5450471", "aliases": [], "types": ["T044"], "canonical_name": "hypoxanthine oxidation"}
{"concept_id": "C5450472", "aliases": [], "types": ["T045"], "canonical_name": "sRNA transcription"}
{"concept_id": "C5450473", "aliases": ["citrate synthase complex", "citrate synthase complex location"], "types": ["T026"], "canonical_name": "citrate synthase complex"}
{"concept_id": "C5450474", "aliases": [], "types": ["T044"], "canonical_name": "shikimate anabolism"}
{"concept_id": "C5450475", "aliases": [], "types": ["T044"], "canonical_name": "shikimate biosynthesis"}
{"concept_id": "C5450476", "aliases": [], "types": ["T044"], "canonical_name": "shikimate biosynthetic process"}
{"concept_id": "C5450477", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome o ubiquinol oxidase activity"}
{"concept_id": "C5450478", "aliases": [], "types": ["T045"], "canonical_name": "viral gene silencing in virus induced gene silencing"}
{"concept_id": "C5450479", "aliases": [], "types": ["T040"], "canonical_name": "viral triggering of virus induced gene silencing"}
{"concept_id": "C5450480", "aliases": [], "types": ["T040"], "canonical_name": "spore germination on or near host"}
{"concept_id": "C5450481", "aliases": [], "types": ["T042"], "canonical_name": "nodule morphogenesis"}
{"concept_id": "C5450482", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent chloride transmembrane transporter activity"}
{"concept_id": "C5450483", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled chloride transmembrane transporter activity"}
{"concept_id": "C5450484", "aliases": [], "types": ["T044"], "canonical_name": "chloride ABC transporter"}
{"concept_id": "C5450485", "aliases": ["chloride transporting ATPase activity"], "types": ["T044"], "canonical_name": "chloride-transporting ATPase activity"}
{"concept_id": "C5450486", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent rhamnose transmembrane transporter activity"}
{"concept_id": "C5450487", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled rhamnose transmembrane transporter activity"}
{"concept_id": "C5450488", "aliases": [], "types": ["T044"], "canonical_name": "rhamnose-transporting ATPase activity"}
{"concept_id": "C5450489", "aliases": [], "types": ["T044"], "canonical_name": "manganese transmembrane transporter activity, phosphorylative mechanism"}
{"concept_id": "C5450490", "aliases": [], "types": ["T044"], "canonical_name": "alkylphosphonate transmembrane transporter activity"}
{"concept_id": "C5450491", "aliases": [], "types": ["T044"], "canonical_name": "organic phosphonate transmembrane transporter activity"}
{"concept_id": "C5450492", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled spermidine transmembrane transporter activity"}
{"concept_id": "C5450493", "aliases": [], "types": ["T044"], "canonical_name": "spermidine porter activity"}
{"concept_id": "C5450494", "aliases": [], "types": ["T044"], "canonical_name": "spermidine-importing ATPase activity"}
{"concept_id": "C5450495", "aliases": [], "types": ["T044"], "canonical_name": "maltooligosaccharide-importing ATPase activity"}
{"concept_id": "C5450496", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent glycerol-2-phosphate transmembrane transporter activity"}
{"concept_id": "C5450497", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled glycerol-2-phosphate transmembrane transporter activity"}
{"concept_id": "C5450498", "aliases": [], "types": ["T044"], "canonical_name": "glycerol-2-phosphate-transporting ATPase activity"}
{"concept_id": "C5450499", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled heme transporter activity"}
{"concept_id": "C5450500", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled fatty-acyl-CoA transmembrane transporter activity"}
{"concept_id": "C5450501", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent iron-chelate transporter activity"}
{"concept_id": "C5450502", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled iron-chelate transporter activity"}
{"concept_id": "C5450503", "aliases": [], "types": ["T044"], "canonical_name": "iron-chelate-transporting ATPase activity"}
{"concept_id": "C5450504", "aliases": [], "types": ["T044"], "canonical_name": "alkylphosphonate transport"}
{"concept_id": "C5450505", "aliases": ["region of membrane"], "types": ["T026"], "canonical_name": "membrane region"}
{"concept_id": "C5450506", "aliases": [], "types": ["T026"], "canonical_name": "whole membrane"}
{"concept_id": "C5450507", "aliases": ["box C/D sRNA metabolic process"], "types": ["T045"], "canonical_name": "box C/D sRNA metabolic process"}
{"concept_id": "C5450508", "aliases": [], "types": ["T045"], "canonical_name": "sRNA catabolic process"}
{"concept_id": "C5450509", "aliases": [], "types": ["T044"], "canonical_name": "glycolate reductase"}
{"concept_id": "C5450510", "aliases": [], "types": ["T044"], "canonical_name": "glyoxylic acid reductase"}
{"concept_id": "C5450511", "aliases": [], "types": ["T044"], "canonical_name": "NADH-dependent glyoxylate reductase"}
{"concept_id": "C5450512", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, reducing metal ions"}
{"concept_id": "C5450513", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, reducing metal ions, NAD or NADP as acceptor"}
{"concept_id": "C5450514", "aliases": [], "types": ["T044"], "canonical_name": "cytosolic dipeptidase activity"}
{"concept_id": "C5450515", "aliases": [], "types": ["T044"], "canonical_name": "steroid hormone receptor binding"}
{"concept_id": "C5450516", "aliases": [], "types": ["T044"], "canonical_name": "gallate metabolic process"}
{"concept_id": "C5450517", "aliases": [], "types": ["T044"], "canonical_name": "gallate metabolism"}
{"concept_id": "C5450518", "aliases": [], "types": ["T044"], "canonical_name": "gallic acid metabolic process"}
{"concept_id": "C5450519", "aliases": [], "types": ["T044"], "canonical_name": "gallic acid metabolism"}
{"concept_id": "C5450520", "aliases": [], "types": ["T044"], "canonical_name": "fluorene metabolic process"}
{"concept_id": "C5450521", "aliases": [], "types": ["T044"], "canonical_name": "divalent inorganic cation transmembrane transporter activity"}
{"concept_id": "C5450522", "aliases": [], "types": ["T044"], "canonical_name": "monovalent inorganic cation transmembrane transporter activity"}
{"concept_id": "C5450523", "aliases": [], "types": ["T044"], "canonical_name": "trivalent inorganic cation transmembrane transporter activity"}
{"concept_id": "C5450524", "aliases": [], "types": ["T043"], "canonical_name": "divalent metal ion transport"}
{"concept_id": "C5450525", "aliases": ["AP-1 related adapter complex location"], "types": ["T026"], "canonical_name": "AP-1 related adapter complex"}
{"concept_id": "C5450526", "aliases": ["formimidoyltransferase activity"], "types": ["T044"], "canonical_name": "formimidoyltransferase activity"}
{"concept_id": "C5450527", "aliases": ["formiminotransferase activity"], "types": ["T044"], "canonical_name": "formiminotransferase activity"}
{"concept_id": "C5450528", "aliases": [], "types": ["T045"], "canonical_name": "sRNA 3'-end processing"}
{"concept_id": "C5450529", "aliases": ["ADP-ribosylation factor binding"], "types": ["T044"], "canonical_name": "ARF binding"}
{"concept_id": "C5450530", "aliases": [], "types": ["T044"], "canonical_name": "GTP-Ral binding"}
{"concept_id": "C5450531", "aliases": [], "types": ["T044"], "canonical_name": "GTP-Rho binding"}
{"concept_id": "C5450532", "aliases": ["Rab escort protein activity"], "types": ["T044"], "canonical_name": "REP"}
{"concept_id": "C5450533", "aliases": [], "types": ["T044"], "canonical_name": "Rab GTPase binding"}
{"concept_id": "C5450534", "aliases": [], "types": ["T044"], "canonical_name": "Rab interactor activity"}
{"concept_id": "C5450535", "aliases": [], "types": ["T044"], "canonical_name": "Rac GTPase binding"}
{"concept_id": "C5450536", "aliases": [], "types": ["T044"], "canonical_name": "Ral GTPase binding"}
{"concept_id": "C5450537", "aliases": [], "types": ["T044"], "canonical_name": "Ran GTPase binding"}
{"concept_id": "C5450538", "aliases": [], "types": ["T044"], "canonical_name": "Ras GTPase binding"}
{"concept_id": "C5450539", "aliases": [], "types": ["T044"], "canonical_name": "Ras interactor activity"}
{"concept_id": "C5450540", "aliases": [], "types": ["T044"], "canonical_name": "Rho GTPase binding"}
{"concept_id": "C5450541", "aliases": ["box C/D snoRNP complex location"], "types": ["T026"], "canonical_name": "box C/D snoRNP complex"}
{"concept_id": "C5450542", "aliases": ["box C/D sRNP complex location"], "types": ["T026"], "canonical_name": "box C/D sRNP complex"}
{"concept_id": "C5450543", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in cell size control checkpoint"}
{"concept_id": "C5450544", "aliases": [], "types": ["T043"], "canonical_name": "G1 cell size control checkpoint signalling"}
{"concept_id": "C5450545", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in G1 cell size control checkpoint"}
{"concept_id": "C5450546", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in mitotic cell cycle G1/S transition size control checkpoint"}
{"concept_id": "C5450547", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in G2 cell size control checkpoint"}
{"concept_id": "C5450548", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in G2/M transition size control checkpoint"}
{"concept_id": "C5450549", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in mitotic cell cycle G2/M transition size control checkpoint"}
{"concept_id": "C5450550", "aliases": [], "types": ["T043"], "canonical_name": "G1 DNA damage checkpoint"}
{"concept_id": "C5450551", "aliases": [], "types": ["T043"], "canonical_name": "G1/S DNA damage checkpoint"}
{"concept_id": "C5450552", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint"}
{"concept_id": "C5450553", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in mitotic G1 DNA damage checkpoint"}
{"concept_id": "C5450554", "aliases": [], "types": ["T040"], "canonical_name": "chemokine biosynthetic process"}
{"concept_id": "C5450555", "aliases": [], "types": ["T040"], "canonical_name": "chemokine metabolic process"}
{"concept_id": "C5450556", "aliases": [], "types": ["T040"], "canonical_name": "chemokine secretion"}
{"concept_id": "C5450557", "aliases": [], "types": ["T040"], "canonical_name": "fractalkine biosynthetic process"}
{"concept_id": "C5450558", "aliases": [], "types": ["T040"], "canonical_name": "fractalkine metabolic process"}
{"concept_id": "C5450559", "aliases": [], "types": ["T040"], "canonical_name": "granulocyte macrophage colony-stimulating factor biosynthetic process"}
{"concept_id": "C5450560", "aliases": [], "types": ["T040"], "canonical_name": "hepatocyte growth factor biosynthetic process"}
{"concept_id": "C5450561", "aliases": [], "types": ["T040"], "canonical_name": "type I interferon biosynthetic process"}
{"concept_id": "C5450562", "aliases": [], "types": ["T040"], "canonical_name": "type I interferon secretion"}
{"concept_id": "C5450563", "aliases": [], "types": ["T040"], "canonical_name": "interferon-alpha biosynthetic process"}
{"concept_id": "C5450564", "aliases": [], "types": ["T040"], "canonical_name": "interferon-alpha secretion"}
{"concept_id": "C5450565", "aliases": [], "types": ["T040"], "canonical_name": "interferon-beta biosynthetic process"}
{"concept_id": "C5450566", "aliases": [], "types": ["T040"], "canonical_name": "interferon-beta secretion"}
{"concept_id": "C5450567", "aliases": [], "types": ["T040"], "canonical_name": "interferon-gamma biosynthetic process"}
{"concept_id": "C5450568", "aliases": [], "types": ["T040"], "canonical_name": "interferon-gamma secretion"}
{"concept_id": "C5450569", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-1 alpha biosynthetic process"}
{"concept_id": "C5450570", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-1 alpha secretion"}
{"concept_id": "C5450571", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-1 beta biosynthetic process"}
{"concept_id": "C5450572", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-1 beta secretion"}
{"concept_id": "C5450573", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-1 biosynthetic process"}
{"concept_id": "C5450574", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-1 secretion"}
{"concept_id": "C5450575", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-10 biosynthetic process"}
{"concept_id": "C5450576", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-10 secretion"}
{"concept_id": "C5450577", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-11 biosynthetic process"}
{"concept_id": "C5450578", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-11 secretion"}
{"concept_id": "C5450579", "aliases": [], "types": ["T040"], "canonical_name": "CLMF production"}
{"concept_id": "C5450580", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-12 biosynthetic process"}
{"concept_id": "C5450581", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-12 secretion"}
{"concept_id": "C5450582", "aliases": [], "types": ["T040"], "canonical_name": "NKSF production"}
{"concept_id": "C5450583", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-13 biosynthetic process"}
{"concept_id": "C5450584", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-13 secretion"}
{"concept_id": "C5450587", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-15 biosynthetic process"}
{"concept_id": "C5450588", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-15 secretion"}
{"concept_id": "C5450589", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-16 biosynthetic process"}
{"concept_id": "C5450590", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-16 secretion"}
{"concept_id": "C5450591", "aliases": [], "types": ["T040"], "canonical_name": "LCF production"}
{"concept_id": "C5450592", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-17 biosynthetic process"}
{"concept_id": "C5450593", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-17 secretion"}
{"concept_id": "C5450594", "aliases": [], "types": ["T040"], "canonical_name": "IL1F4 production"}
{"concept_id": "C5450595", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-18 biosynthetic process"}
{"concept_id": "C5450596", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-18 secretion"}
{"concept_id": "C5450597", "aliases": ["interleukin-19 secretion"], "types": ["T040"], "canonical_name": "IL-19 secretion"}
{"concept_id": "C5450598", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-19 biosynthetic process"}
{"concept_id": "C5450599", "aliases": [], "types": ["T040"], "canonical_name": "ZMDA1 secretion"}
{"concept_id": "C5450600", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-2 biosynthetic process"}
{"concept_id": "C5450601", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-2 secretion"}
{"concept_id": "C5450602", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-20 biosynthetic process"}
{"concept_id": "C5450603", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-20 secretion"}
{"concept_id": "C5450604", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-21 biosynthetic process"}
{"concept_id": "C5450605", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-21 secretion"}
{"concept_id": "C5450606", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-22 biosynthetic process"}
{"concept_id": "C5450607", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-22 secretion"}
{"concept_id": "C5450608", "aliases": [], "types": ["T040"], "canonical_name": "ZCYTO18 production"}
{"concept_id": "C5450609", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-23 biosynthetic process"}
{"concept_id": "C5450610", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-23 secretion"}
{"concept_id": "C5450611", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-24 biosynthetic process"}
{"concept_id": "C5450612", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-24 secretion"}
{"concept_id": "C5450613", "aliases": [], "types": ["T040"], "canonical_name": "MDA7 production"}
{"concept_id": "C5450614", "aliases": [], "types": ["T040"], "canonical_name": "ST16 production"}
{"concept_id": "C5450615", "aliases": [], "types": ["T040"], "canonical_name": "IL-25 secretion"}
{"concept_id": "C5450616", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-25 anabolism"}
{"concept_id": "C5450617", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-25 biosynthesis"}
{"concept_id": "C5450618", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-25 biosynthetic process"}
{"concept_id": "C5450619", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-25 formation"}
{"concept_id": "C5450620", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-25 secretion"}
{"concept_id": "C5450621", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-25 synthesis"}
{"concept_id": "C5450622", "aliases": [], "types": ["T040"], "canonical_name": "AK155 secretion"}
{"concept_id": "C5450623", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-26 anabolism"}
{"concept_id": "C5450624", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-26 biosynthesis"}
{"concept_id": "C5450625", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-26 biosynthetic process"}
{"concept_id": "C5450626", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-26 formation"}
{"concept_id": "C5450627", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-26 secretion"}
{"concept_id": "C5450628", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-26 synthesis"}
{"concept_id": "C5450629", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-27 biosynthetic process"}
{"concept_id": "C5450630", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-27 formation"}
{"concept_id": "C5450631", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-27 secretion"}
{"concept_id": "C5450632", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-27 synthesis"}
{"concept_id": "C5450633", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-3 biosynthetic process"}
{"concept_id": "C5450634", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-3 secretion"}
{"concept_id": "C5450635", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-4 biosynthetic process"}
{"concept_id": "C5450636", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-4 secretion"}
{"concept_id": "C5450637", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-5 biosynthetic process"}
{"concept_id": "C5450638", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-5 secretion"}
{"concept_id": "C5450639", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-6 biosynthetic process"}
{"concept_id": "C5450640", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-6 secretion"}
{"concept_id": "C5450641", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-7 biosynthetic process"}
{"concept_id": "C5450642", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-7 secretion"}
{"concept_id": "C5450643", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-8 biosynthetic process"}
{"concept_id": "C5450644", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-8 secretion"}
{"concept_id": "C5450645", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-9 biosynthetic process"}
{"concept_id": "C5450646", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-9 secretion"}
{"concept_id": "C5450647", "aliases": [], "types": ["T040"], "canonical_name": "TRAIL biosynthetic process"}
{"concept_id": "C5450648", "aliases": ["TNF-alpha biosynthesis"], "types": ["T040"], "canonical_name": "TNF alpha biosynthesis"}
{"concept_id": "C5450649", "aliases": [], "types": ["T040"], "canonical_name": "TNF biosynthesis"}
{"concept_id": "C5450650", "aliases": [], "types": ["T040"], "canonical_name": "TNF biosynthetic process"}
{"concept_id": "C5450651", "aliases": [], "types": ["T040"], "canonical_name": "TNF-alpha biosynthetic process"}
{"concept_id": "C5450652", "aliases": [], "types": ["T040"], "canonical_name": "Tnfa production"}
{"concept_id": "C5450653", "aliases": [], "types": ["T040"], "canonical_name": "tumor necrosis factor anabolism"}
{"concept_id": "C5450654", "aliases": [], "types": ["T040"], "canonical_name": "tumor necrosis factor biosynthesis"}
{"concept_id": "C5450655", "aliases": [], "types": ["T040"], "canonical_name": "tumor necrosis factor biosynthetic process"}
{"concept_id": "C5450656", "aliases": [], "types": ["T040"], "canonical_name": "tumor necrosis factor formation"}
{"concept_id": "C5450657", "aliases": [], "types": ["T040"], "canonical_name": "tumor necrosis factor secretion"}
{"concept_id": "C5450658", "aliases": [], "types": ["T040"], "canonical_name": "tumor necrosis factor synthesis"}
{"concept_id": "C5450659", "aliases": [], "types": ["T040"], "canonical_name": "lymphotoxin A biosynthetic process"}
{"concept_id": "C5450660", "aliases": [], "types": ["T040"], "canonical_name": "lymphotoxin A formation"}
{"concept_id": "C5450661", "aliases": [], "types": ["T040"], "canonical_name": "lymphotoxin A synthesis"}
{"concept_id": "C5450662", "aliases": [], "types": ["T040"], "canonical_name": "regulation of chemokine biosynthetic process"}
{"concept_id": "C5450663", "aliases": [], "types": ["T040"], "canonical_name": "regulation of chemokine secretion"}
{"concept_id": "C5450664", "aliases": [], "types": ["T040"], "canonical_name": "regulation of connective tissue growth factor biosynthetic process"}
{"concept_id": "C5450665", "aliases": [], "types": ["T040"], "canonical_name": "regulation of CX3CL1 biosynthesis"}
{"concept_id": "C5450666", "aliases": [], "types": ["T040"], "canonical_name": "regulation of CX3CL1 production"}
{"concept_id": "C5450667", "aliases": [], "types": ["T040"], "canonical_name": "regulation of fractalkine biosynthetic process"}
{"concept_id": "C5450668", "aliases": [], "types": ["T040"], "canonical_name": "regulation of granulocyte macrophage colony-stimulating factor biosynthetic process"}
{"concept_id": "C5450669", "aliases": [], "types": ["T040"], "canonical_name": "regulation of hepatocyte growth factor biosynthetic process"}
{"concept_id": "C5450670", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interferon-alpha biosynthetic process"}
{"concept_id": "C5450671", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interferon-alpha secretion"}
{"concept_id": "C5450672", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interferon-beta biosynthetic process"}
{"concept_id": "C5450673", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interferon-beta secretion"}
{"concept_id": "C5450674", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interferon-gamma biosynthetic process"}
{"concept_id": "C5450675", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-1 alpha biosynthetic process"}
{"concept_id": "C5450676", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-1 alpha secretion"}
{"concept_id": "C5450677", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-1 beta biosynthetic process"}
{"concept_id": "C5450678", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-1 beta secretion"}
{"concept_id": "C5450679", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-1 biosynthetic process"}
{"concept_id": "C5450680", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-1 secretion"}
{"concept_id": "C5450681", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-10 biosynthetic process"}
{"concept_id": "C5450682", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-10 secretion"}
{"concept_id": "C5450683", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-11 biosynthetic process"}
{"concept_id": "C5450684", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-11 secretion"}
{"concept_id": "C5450685", "aliases": [], "types": ["T040"], "canonical_name": "regulation of CLMF production"}
{"concept_id": "C5450686", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-12 biosynthetic process"}
{"concept_id": "C5450687", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-12 secretion"}
{"concept_id": "C5450688", "aliases": [], "types": ["T040"], "canonical_name": "regulation of NKSF production"}
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{"concept_id": "C5450693", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-16 biosynthetic process"}
{"concept_id": "C5450694", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-17 biosynthetic process"}
{"concept_id": "C5450695", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-17 secretion"}
{"concept_id": "C5450696", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-18 biosynthetic process"}
{"concept_id": "C5450697", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-18 secretion"}
{"concept_id": "C5450698", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-19 biosynthetic process"}
{"concept_id": "C5450699", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-2 biosynthetic process"}
{"concept_id": "C5450700", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-2 secretion"}
{"concept_id": "C5450701", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-20 biosynthetic process"}
{"concept_id": "C5450702", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-21 biosynthetic process"}
{"concept_id": "C5450703", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-22 biosynthetic process"}
{"concept_id": "C5450704", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-23 anabolism"}
{"concept_id": "C5450705", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-23 biosynthesis"}
{"concept_id": "C5450706", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-23 biosynthetic process"}
{"concept_id": "C5450707", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-23 formation"}
{"concept_id": "C5450708", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-23 synthesis"}
{"concept_id": "C5450709", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-24 biosynthetic process"}
{"concept_id": "C5450710", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-25 biosynthetic process"}
{"concept_id": "C5450711", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-25 secretion"}
{"concept_id": "C5450712", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-26 biosynthetic process"}
{"concept_id": "C5450713", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-27 biosynthetic process"}
{"concept_id": "C5450714", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-27 formation"}
{"concept_id": "C5450715", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-27 synthesis"}
{"concept_id": "C5450716", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-3 biosynthetic process"}
{"concept_id": "C5450717", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-4 biosynthetic process"}
{"concept_id": "C5450718", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-4 secretion"}
{"concept_id": "C5450719", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-5 biosynthetic process"}
{"concept_id": "C5450720", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-5 secretion"}
{"concept_id": "C5450721", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-6 biosynthetic process"}
{"concept_id": "C5450722", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-7 biosynthetic process"}
{"concept_id": "C5450723", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-7 secretion"}
{"concept_id": "C5450724", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-8 biosynthetic process"}
{"concept_id": "C5450725", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-8 secretion"}
{"concept_id": "C5450726", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-9 biosynthetic process"}
{"concept_id": "C5450727", "aliases": [], "types": ["T040"], "canonical_name": "regulation of TRAIL biosynthetic process"}
{"concept_id": "C5450728", "aliases": [], "types": ["T040"], "canonical_name": "regulation of tumor necrosis factor biosynthetic process"}
{"concept_id": "C5450729", "aliases": [], "types": ["T040"], "canonical_name": "regulation of tumor necrosis factor secretion"}
{"concept_id": "C5450730", "aliases": [], "types": ["T040"], "canonical_name": "regulation of lymphotoxin A biosynthetic process"}
{"concept_id": "C5450731", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of chemokine biosynthetic process"}
{"concept_id": "C5450732", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of chemokine secretion"}
{"concept_id": "C5450733", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of connective tissue growth factor biosynthetic process"}
{"concept_id": "C5450734", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of CX3CL1 biosynthesis"}
{"concept_id": "C5450735", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of fractalkine biosynthetic process"}
{"concept_id": "C5450736", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process"}
{"concept_id": "C5450737", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of hepatocyte growth factor biosynthetic process"}
{"concept_id": "C5450738", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interferon-alpha biosynthetic process"}
{"concept_id": "C5450739", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interferon-alpha secretion"}
{"concept_id": "C5450740", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interferon-beta biosynthetic process"}
{"concept_id": "C5450741", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interferon-beta secretion"}
{"concept_id": "C5450742", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interferon-gamma biosynthetic process"}
{"concept_id": "C5450743", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interferon-gamma secretion"}
{"concept_id": "C5450744", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-1 alpha biosynthetic process"}
{"concept_id": "C5450745", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-1 alpha secretion"}
{"concept_id": "C5450746", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-1 beta biosynthetic process"}
{"concept_id": "C5450747", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-1 beta secretion"}
{"concept_id": "C5450748", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-1 biosynthetic process"}
{"concept_id": "C5450749", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-1 secretion"}
{"concept_id": "C5450750", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-10 biosynthetic process"}
{"concept_id": "C5450751", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-10 secretion"}
{"concept_id": "C5450752", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-11 biosynthetic process"}
{"concept_id": "C5450753", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-11 secretion"}
{"concept_id": "C5450754", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of CLMF production"}
{"concept_id": "C5450755", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-12 biosynthetic process"}
{"concept_id": "C5450756", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-12 secretion"}
{"concept_id": "C5450757", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of NKSF production"}
{"concept_id": "C5450758", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-13 biosynthetic process"}
{"concept_id": "C5450759", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-13 secretion"}
{"concept_id": "C5450761", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-15 biosynthetic process"}
{"concept_id": "C5450762", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-16 biosynthetic process"}
{"concept_id": "C5450763", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of CTLA-8 production"}
{"concept_id": "C5450764", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-17 biosynthetic process"}
{"concept_id": "C5450765", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-17 secretion"}
{"concept_id": "C5450766", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-18 biosynthetic process"}
{"concept_id": "C5450767", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-18 secretion"}
{"concept_id": "C5450768", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-19 biosynthetic process"}
{"concept_id": "C5450769", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-2 biosynthetic process"}
{"concept_id": "C5450770", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-2 secretion"}
{"concept_id": "C5450771", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-20 biosynthetic process"}
{"concept_id": "C5450772", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-21 biosynthetic process"}
{"concept_id": "C5450773", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-22 biosynthetic process"}
{"concept_id": "C5450774", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-23 biosynthetic process"}
{"concept_id": "C5450775", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-24 biosynthetic process"}
{"concept_id": "C5450776", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-25 biosynthetic process"}
{"concept_id": "C5450777", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-25 secretion"}
{"concept_id": "C5450778", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-26 biosynthetic process"}
{"concept_id": "C5450779", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-27 biosynthetic process"}
{"concept_id": "C5450780", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-3 biosynthetic process"}
{"concept_id": "C5450781", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-4 biosynthetic process"}
{"concept_id": "C5450782", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-4 secretion"}
{"concept_id": "C5450783", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-5 biosynthetic process"}
{"concept_id": "C5450784", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-5 secretion"}
{"concept_id": "C5450785", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-6 biosynthetic process"}
{"concept_id": "C5450786", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-6 secretion"}
{"concept_id": "C5450787", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-7 biosynthetic process"}
{"concept_id": "C5450788", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-7 secretion"}
{"concept_id": "C5450789", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-8 biosynthetic process"}
{"concept_id": "C5450790", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-8 secretion"}
{"concept_id": "C5450791", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-9 biosynthetic process"}
{"concept_id": "C5450792", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of TRAIL biosynthetic process"}
{"concept_id": "C5450793", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of cachectin production"}
{"concept_id": "C5450794", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of tumor necrosis factor biosynthetic process"}
{"concept_id": "C5450795", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of tumor necrosis factor secretion"}
{"concept_id": "C5450796", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of lymphotoxin A biosynthetic process"}
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{"concept_id": "C5450798", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of chemokine secretion"}
{"concept_id": "C5450799", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of connective tissue growth factor biosynthetic process"}
{"concept_id": "C5450800", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process"}
{"concept_id": "C5450801", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of hepatocyte growth factor biosynthetic process"}
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{"concept_id": "C5450803", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interferon-alpha secretion"}
{"concept_id": "C5450804", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interferon-beta biosynthetic process"}
{"concept_id": "C5450805", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interferon-beta secretion"}
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{"concept_id": "C5450811", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-1 beta secretion"}
{"concept_id": "C5450812", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-1 biosynthetic process"}
{"concept_id": "C5450813", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-1 secretion"}
{"concept_id": "C5450814", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-10 biosynthetic process"}
{"concept_id": "C5450815", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-10 secretion"}
{"concept_id": "C5450816", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-11 biosynthetic process"}
{"concept_id": "C5450817", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-11 secretion"}
{"concept_id": "C5450818", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of CLMF production"}
{"concept_id": "C5450819", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-12 biosynthetic process"}
{"concept_id": "C5450820", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-12 secretion"}
{"concept_id": "C5450821", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of NKSF production"}
{"concept_id": "C5450822", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-13 biosynthetic process"}
{"concept_id": "C5450823", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-13 secretion"}
{"concept_id": "C5450825", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-15 biosynthetic process"}
{"concept_id": "C5450826", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-16 biosynthetic process"}
{"concept_id": "C5450827", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-17 biosynthetic process"}
{"concept_id": "C5450828", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-17 secretion"}
{"concept_id": "C5450829", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-18 biosynthetic process"}
{"concept_id": "C5450830", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-18 secretion"}
{"concept_id": "C5450831", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-19 biosynthetic process"}
{"concept_id": "C5450832", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-2 biosynthetic process"}
{"concept_id": "C5450833", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-2 secretion"}
{"concept_id": "C5450834", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-20 biosynthetic process"}
{"concept_id": "C5450835", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-21 biosynthetic process"}
{"concept_id": "C5450836", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-22 biosynthetic process"}
{"concept_id": "C5450837", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-23 biosynthetic process"}
{"concept_id": "C5450838", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-24 biosynthetic process"}
{"concept_id": "C5450839", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-25 biosynthetic process"}
{"concept_id": "C5450840", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-25 secretion"}
{"concept_id": "C5450841", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-26 biosynthetic process"}
{"concept_id": "C5450842", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-27 anabolism"}
{"concept_id": "C5450843", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-27 biosynthetic process"}
{"concept_id": "C5450844", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-3 biosynthetic process"}
{"concept_id": "C5450845", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-4 biosynthetic process"}
{"concept_id": "C5450846", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-4 secretion"}
{"concept_id": "C5450847", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-5 biosynthetic process"}
{"concept_id": "C5450848", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-5 secretion"}
{"concept_id": "C5450849", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-6 biosynthetic process"}
{"concept_id": "C5450850", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-6 secretion"}
{"concept_id": "C5450851", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-7 biosynthetic process"}
{"concept_id": "C5450852", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-7 secretion"}
{"concept_id": "C5450853", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-8 biosynthetic process"}
{"concept_id": "C5450854", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-8 secretion"}
{"concept_id": "C5450855", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-9 biosynthetic process"}
{"concept_id": "C5450856", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of TRAIL biosynthetic process"}
{"concept_id": "C5450857", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of cachectin secretion"}
{"concept_id": "C5450858", "aliases": ["positive regulation of tumor necrosis factor secretion"], "types": ["T040"], "canonical_name": "positive regulation of TNF secretion"}
{"concept_id": "C5450859", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of tumor necrosis factor biosynthesis"}
{"concept_id": "C5450860", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of tumor necrosis factor biosynthetic process"}
{"concept_id": "C5450861", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of tumor necrosis factor formation"}
{"concept_id": "C5450862", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of lymphotoxin A biosynthetic process"}
{"concept_id": "C5450863", "aliases": [], "types": ["T044"], "canonical_name": "oligogalacturonide transmembrane transporter activity"}
{"concept_id": "C5450864", "aliases": [], "types": ["T044"], "canonical_name": "2-aminoethylphosphonate transmembrane transporter activity"}
{"concept_id": "C5450865", "aliases": [], "types": ["T044"], "canonical_name": "2-phosphonoethylamine transmembrane transporter activity"}
{"concept_id": "C5450866", "aliases": [], "types": ["T044"], "canonical_name": "ciliatine transporter activity"}
{"concept_id": "C5450867", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent methionine transmembrane transporter activity"}
{"concept_id": "C5450868", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled methionine transmembrane transporter activity"}
{"concept_id": "C5450869", "aliases": [], "types": ["T044"], "canonical_name": "D-methionine transmembrane transporter activity"}
{"concept_id": "C5450870", "aliases": [], "types": ["T044"], "canonical_name": "D-methionine transporter activity"}
{"concept_id": "C5450871", "aliases": [], "types": ["T044"], "canonical_name": "methionine transmembrane-transporting ATPase activity"}
{"concept_id": "C5450872", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in mitotic DNA replication checkpoint"}
{"concept_id": "C5450873", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction involved in mitotic G2/M transition decatenation checkpoint"}
{"concept_id": "C5450874", "aliases": [], "types": ["T026"], "canonical_name": "nuclear rDNA heterochromatin"}
{"concept_id": "C5450875", "aliases": [], "types": ["T026"], "canonical_name": "ribosomal DNA heterochromatin of cell nucleus"}
{"concept_id": "C5450876", "aliases": [], "types": ["T026"], "canonical_name": "ribosomal DNA heterochromatin of nucleus"}
{"concept_id": "C5450877", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA sRNA metabolic process"}
{"concept_id": "C5450878", "aliases": [], "types": ["T040"], "canonical_name": "enhancement by symbiont of host defense-related programmed cell death"}
{"concept_id": "C5450879", "aliases": [], "types": ["T045"], "canonical_name": "mitochondrial DNA-binding transcription factor activity"}
{"concept_id": "C5450880", "aliases": [], "types": ["T040"], "canonical_name": "type III interferon secretion"}
{"concept_id": "C5450881", "aliases": [], "types": ["T045"], "canonical_name": "box C/D sRNA binding"}
{"concept_id": "C5450882", "aliases": [], "types": ["T045"], "canonical_name": "box C/D sRNA processing"}
{"concept_id": "C5450883", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA sRNA processing"}
{"concept_id": "C5450884", "aliases": [], "types": ["T045"], "canonical_name": "intronic box C/D sRNA processing"}
{"concept_id": "C5450885", "aliases": [], "types": ["T044"], "canonical_name": "inositol hexakisphosphate synthase"}
{"concept_id": "C5450886", "aliases": [], "types": ["T040"], "canonical_name": "chemokine (C-C motif) ligand 6 secretion"}
{"concept_id": "C5450887", "aliases": [], "types": ["T040"], "canonical_name": "regulation of chemokine (C-C motif) ligand 6 secretion"}
{"concept_id": "C5450888", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of chemokine (C-C motif) ligand 6 secretion"}
{"concept_id": "C5450889", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of chemokine (C-C motif) ligand 6 secretion"}
{"concept_id": "C5450890", "aliases": [], "types": ["T040"], "canonical_name": "transmigration of symbiont in host"}
{"concept_id": "C5450891", "aliases": [], "types": ["T044"], "canonical_name": "ATPase activity, coupled to movement of substances"}
{"concept_id": "C5450892", "aliases": [], "types": ["T040"], "canonical_name": "defense response to bacterium, incompatible interaction"}
{"concept_id": "C5450893", "aliases": ["resistance response to pathogenic bacterium"], "types": ["T040"], "canonical_name": "resistance response to pathogenic bacteria"}
{"concept_id": "C5450894", "aliases": [], "types": ["T046"], "canonical_name": "defense response to protozoan, incompatible interaction"}
{"concept_id": "C5450895", "aliases": ["resistance response to pathogenic protozoan"], "types": ["T046"], "canonical_name": "resistance response to pathogenic protozoa"}
{"concept_id": "C5450896", "aliases": [], "types": ["T045"], "canonical_name": "sRNA 3'-end cleavage"}
{"concept_id": "C5450897", "aliases": ["Z granule"], "types": ["T026"], "definition": "A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells that are distinct from, but colocalize with or are adjacent to, P granules and mutator foci and are associated with RNA metabolism. Z granules have been observed in C. elegans. [GOC:dr, GOC:krc, PMID:29769721, PMID:31378614, PMID:32650583]", "canonical_name": "germline granule"}
{"concept_id": "C5450898", "aliases": [], "types": ["T044"], "canonical_name": "aryl-CoA synthetase (ADP-forming) activity"}
{"concept_id": "C5450899", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, reducing metal ions, flavin as acceptor"}
{"concept_id": "C5450900", "aliases": [], "types": ["T040"], "canonical_name": "development of symbiont during interaction with host"}
{"concept_id": "C5450901", "aliases": [], "types": ["T040"], "canonical_name": "development of symbiont involved in interaction with host"}
{"concept_id": "C5450902", "aliases": [], "types": ["T040"], "canonical_name": "multi-species biofilm formation in or on host organism"}
{"concept_id": "C5450903", "aliases": [], "types": ["T040"], "canonical_name": "multi-species biofilm formation on inanimate substrate"}
{"concept_id": "C5450904", "aliases": [], "types": ["T040"], "canonical_name": "multi-species submerged biofilm formation"}
{"concept_id": "C5450905", "aliases": [], "types": ["T040"], "canonical_name": "multi-species surface biofilm formation"}
{"concept_id": "C5450906", "aliases": [], "types": ["T026"], "canonical_name": "complete virus particle"}
{"concept_id": "C5450907", "aliases": [], "types": ["T043"], "canonical_name": "glial cell line-derived neurotrophic factor production"}
{"concept_id": "C5450908", "aliases": [], "types": ["T043"], "canonical_name": "intracellular signal transduction pathway involved in mitotic DNA damage checkpoint"}
{"concept_id": "C5450909", "aliases": [], "types": ["T043"], "canonical_name": "intracellular signaling pathway involved in mitotic DNA damage checkpoint"}
{"concept_id": "C5450910", "aliases": [], "types": ["T043"], "canonical_name": "intracellular signal transduction pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint"}
{"concept_id": "C5450911", "aliases": [], "types": ["T043"], "canonical_name": "intracellular signal transduction pathway involved in topo II checkpoint"}
{"concept_id": "C5450912", "aliases": [], "types": ["T043"], "canonical_name": "intracellular signal transduction pathway involved in topoisomerase II checkpoint"}
{"concept_id": "C5450913", "aliases": [], "types": ["T043"], "canonical_name": "intracellular signaling pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint"}
{"concept_id": "C5450914", "aliases": [], "types": ["T043"], "canonical_name": "intracellular signaling pathway involved in topo II checkpoint"}
{"concept_id": "C5450915", "aliases": [], "types": ["T043"], "canonical_name": "intracellular signaling pathway involved in topoisomerase II checkpoint"}
{"concept_id": "C5450916", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction via intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint"}
{"concept_id": "C5450917", "aliases": [], "types": ["T043"], "canonical_name": "signal transduction via intracellular signaling cascade involved in topo II checkpoint"}
{"concept_id": "C5450918", "aliases": [], "types": ["T044"], "canonical_name": "heme-thiolate"}
{"concept_id": "C5450919", "aliases": [], "types": ["T044"], "canonical_name": "oximinotransaminase activity"}
{"concept_id": "C5450920", "aliases": [], "types": ["T044"], "canonical_name": "ferulate-CoA ligase activity"}
{"concept_id": "C5450921", "aliases": [], "types": ["T044"], "canonical_name": "delta(11) desaturase"}
{"concept_id": "C5450922", "aliases": ["fatty acid delta(11)-desaturase"], "types": ["T044"], "canonical_name": "delta(11)-fatty-acid desaturase"}
{"concept_id": "C5450923", "aliases": [], "types": ["T044"], "canonical_name": "delta(11)-palmitoyl-CoA desaturase"}
{"concept_id": "C5450924", "aliases": [], "types": ["T044"], "canonical_name": "Z/E11-desaturase"}
{"concept_id": "C5450925", "aliases": [], "types": ["T040"], "canonical_name": "defense response to fungus, incompatible interaction"}
{"concept_id": "C5450926", "aliases": ["resistance response to pathogenic fungus"], "types": ["T040"], "canonical_name": "resistance response to pathogenic fungi"}
{"concept_id": "C5450927", "aliases": [], "types": ["T043"], "canonical_name": "nuclear pore distribution"}
{"concept_id": "C5450928", "aliases": [], "types": ["T043"], "canonical_name": "positioning of nuclear pores"}
{"concept_id": "C5450929", "aliases": [], "types": ["T040"], "canonical_name": "growth of symbiont in host"}
{"concept_id": "C5450930", "aliases": [], "types": ["T040"], "canonical_name": "growth of symbiont in host cell"}
{"concept_id": "C5450931", "aliases": [], "types": ["T040"], "canonical_name": "growth of symbiont in host organelle"}
{"concept_id": "C5450932", "aliases": [], "types": ["T040"], "canonical_name": "growth of symbiont in host vacuole"}
{"concept_id": "C5450933", "aliases": [], "types": ["T040"], "canonical_name": "modulation by organism of apoptotic process in other organism involved in symbiotic interaction"}
{"concept_id": "C5450934", "aliases": [], "types": ["T040"], "canonical_name": "modulation of programmed cell death in other organism"}
{"concept_id": "C5450935", "aliases": [], "types": ["T040"], "canonical_name": "modulation of programmed cell death in other organism involved in symbiotic interaction"}
{"concept_id": "C5450937", "aliases": [], "types": ["T040"], "canonical_name": "activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction"}
{"concept_id": "C5450938", "aliases": [], "types": ["T040"], "canonical_name": "enhancement of other organism programmed cell death by organism"}
{"concept_id": "C5450943", "aliases": [], "types": ["T043"], "canonical_name": "arrest of mitotic cell cycle progression"}
{"concept_id": "C5450944", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cell cycle arrest"}
{"concept_id": "C5450945", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of cell cycle arrest"}
{"concept_id": "C5450946", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell cycle arrest"}
{"concept_id": "C5450947", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell cycle arrest"}
{"concept_id": "C5450949", "aliases": [], "types": ["T043"], "canonical_name": "heart muscle fiber development"}
{"concept_id": "C5450950", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of coflocculation"}
{"concept_id": "C5450951", "aliases": ["endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site"], "types": ["T043"], "canonical_name": "endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site"}
{"concept_id": "C5450952", "aliases": [], "types": ["T043"], "canonical_name": "ER localization involved in ER polarization at cell division site"}
{"concept_id": "C5450953", "aliases": ["establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site"], "types": ["T043"], "canonical_name": "establishment of endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site"}
{"concept_id": "C5450954", "aliases": [], "types": ["T043"], "canonical_name": "maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site"}
{"concept_id": "C5450955", "aliases": [], "types": ["T043"], "canonical_name": "transitional endoplasmic reticulum polarization at cell division site"}
{"concept_id": "C5450956", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II activating transcription factor binding"}
{"concept_id": "C5450957", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II repressing transcription factor binding"}
{"concept_id": "C5450958", "aliases": [], "types": ["T045"], "canonical_name": "RNA polymerase II transcription factor binding"}
{"concept_id": "C5450959", "aliases": [], "types": ["T026"], "canonical_name": "nuclear CENP-A containing chromatin"}
{"concept_id": "C5450960", "aliases": [], "types": ["T044"], "canonical_name": "aspartate beta-hydroxylase activity"}
{"concept_id": "C5450961", "aliases": [], "types": ["T044"], "canonical_name": "aspartyl/asparaginyl beta-hydroxylase activity"}
{"concept_id": "C5450962", "aliases": [], "types": ["T044"], "canonical_name": "aspartylpeptide beta-dioxygenase activity"}
{"concept_id": "C5450963", "aliases": [], "types": ["T044"], "canonical_name": "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity"}
{"concept_id": "C5450964", "aliases": [], "types": ["T044"], "canonical_name": "multiradiene synthase activity"}
{"concept_id": "C5450965", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-35 biosynthetic process"}
{"concept_id": "C5450966", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-35 secretion"}
{"concept_id": "C5450967", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-35 biosynthetic process"}
{"concept_id": "C5450968", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-35 biosynthetic process"}
{"concept_id": "C5450969", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-35 biosynthetic process"}
{"concept_id": "C5450970", "aliases": ["PS1 complex location"], "types": ["T026"], "canonical_name": "PS1 complex"}
{"concept_id": "C5450971", "aliases": ["PS2 complex location"], "types": ["T026"], "canonical_name": "PS2 complex"}
{"concept_id": "C5450972", "aliases": [], "types": ["T045"], "canonical_name": "sRNA polyadenylation"}
{"concept_id": "C5450973", "aliases": [], "types": ["T043"], "canonical_name": "topo II checkpoint"}
{"concept_id": "C5450974", "aliases": [], "types": ["T043"], "canonical_name": "topoisomerase II checkpoint"}
{"concept_id": "C5450975", "aliases": [], "types": ["T044"], "canonical_name": "transforming growth factor-beta secretion"}
{"concept_id": "C5450976", "aliases": [], "types": ["T040"], "canonical_name": "regulation of transforming growth factor-beta secretion"}
{"concept_id": "C5450977", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of transforming growth factor-beta secretion"}
{"concept_id": "C5450978", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of transforming growth factor-beta secretion"}
{"concept_id": "C5450979", "aliases": ["EGO complex location"], "types": ["T026"], "canonical_name": "EGO complex"}
{"concept_id": "C5450980", "aliases": ["EGO-GSE complex location"], "types": ["T026"], "canonical_name": "EGO-GSE complex"}
{"concept_id": "C5450981", "aliases": ["GSE complex location"], "types": ["T026"], "canonical_name": "GSE complex"}
{"concept_id": "C5450982", "aliases": ["GTPase-containing complex location for Gap1p sorting in the endosome"], "types": ["T026"], "canonical_name": "GTPase-containing complex for Gap1p sorting in the endosome"}
{"concept_id": "C5450983", "aliases": [], "types": ["T043"], "canonical_name": "chaperone-mediated protein transport across periplasmic space"}
{"concept_id": "C5450984", "aliases": [], "types": ["T039"], "canonical_name": "cardiovascular system development"}
{"concept_id": "C5450985", "aliases": ["GET4-GET5 transmembrane domain recognition complex location"], "types": ["T026"], "canonical_name": "GET4-GET5 transmembrane domain recognition complex"}
{"concept_id": "C5450986", "aliases": [], "types": ["T026"], "canonical_name": "viral assembly site"}
{"concept_id": "C5450987", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-28A secretion"}
{"concept_id": "C5450988", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-28B secretion"}
{"concept_id": "C5450989", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-29 secretion"}
{"concept_id": "C5450990", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-30 secretion"}
{"concept_id": "C5450991", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-31 secretion"}
{"concept_id": "C5450992", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-32 biosynthetic process"}
{"concept_id": "C5450993", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-32 secretion"}
{"concept_id": "C5450994", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-33 biosynthetic process"}
{"concept_id": "C5450995", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-33 secretion"}
{"concept_id": "C5450996", "aliases": [], "types": ["T040"], "canonical_name": "interferon-delta secretion"}
{"concept_id": "C5450997", "aliases": [], "types": ["T040"], "canonical_name": "interferon-epsilon secretion"}
{"concept_id": "C5450998", "aliases": [], "types": ["T040"], "canonical_name": "interferon-kappa secretion"}
{"concept_id": "C5450999", "aliases": [], "types": ["T040"], "canonical_name": "interferon-tau secretion"}
{"concept_id": "C5451000", "aliases": [], "types": ["T040"], "canonical_name": "interferon-omega secretion"}
{"concept_id": "C5451001", "aliases": [], "types": ["T040"], "canonical_name": "formation of host penetration structure"}
{"concept_id": "C5451002", "aliases": [], "types": ["T040"], "canonical_name": "modulation of sporangium germination"}
{"concept_id": "C5451003", "aliases": [], "types": ["T040"], "canonical_name": "regulation of encysted zoospore germination on or near host"}
{"concept_id": "C5451004", "aliases": [], "types": ["T040"], "canonical_name": "activation of HR"}
{"concept_id": "C5451005", "aliases": [], "types": ["T040"], "canonical_name": "activation of hypersensitive response"}
{"concept_id": "C5451006", "aliases": [], "types": ["T040"], "canonical_name": "necrotrophic effector"}
{"concept_id": "C5451007", "aliases": [], "types": ["T043"], "canonical_name": "atrioventricular junction myocyte to bundle branch myocyte"}
{"concept_id": "C5451008", "aliases": [], "types": ["T043"], "canonical_name": "bundle branch myocyte to Purkinje myocyte communication"}
{"concept_id": "C5451009", "aliases": [], "types": ["T043"], "canonical_name": "bundle of His myocyte to atrioventricular junction myocyte"}
{"concept_id": "C5451010", "aliases": [], "types": ["T043"], "canonical_name": "cell motility involved in somitogenic axis elongation"}
{"concept_id": "C5451011", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-17A biosynthetic process"}
{"concept_id": "C5451012", "aliases": ["defense response, incompatible interaction"], "types": ["T040"], "canonical_name": "defence response incompatible interaction"}
{"concept_id": "C5451013", "aliases": [], "types": ["T040"], "canonical_name": "defence response to pathogen, incompatible interaction"}
{"concept_id": "C5451014", "aliases": [], "types": ["T040"], "canonical_name": "resistance response to pathogen"}
{"concept_id": "C5451015", "aliases": [], "types": ["T044"], "canonical_name": "divalent inorganic cation transport"}
{"concept_id": "C5451016", "aliases": [], "types": ["T044"], "canonical_name": "monovalent inorganic cation transport"}
{"concept_id": "C5451017", "aliases": [], "types": ["T026"], "canonical_name": "nuclear subtelomeric heterochromatin"}
{"concept_id": "C5451018", "aliases": [], "types": ["T026"], "canonical_name": "sub-telomeric heterochromatin"}
{"concept_id": "C5451019", "aliases": ["subtelomeric heterochromatin"], "types": ["T026"], "canonical_name": "subtelomeric heterochromatin", "definition": "Heterochromatin that is located adjacent to the telomere, and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). [PMID:34576871]"}
{"concept_id": "C5451020", "aliases": [], "types": ["T044"], "canonical_name": "neryl-diphosphate:isopentenyl-diphosphate cistransferase activity"}
{"concept_id": "C5451021", "aliases": [], "types": ["T044"], "canonical_name": "fructosamine-3-kinase activity"}
{"concept_id": "C5451022", "aliases": [], "types": ["T044"], "canonical_name": "cholesterol UDP-glucosyltransferase activity"}
{"concept_id": "C5451023", "aliases": ["membrane-cytoskeletal protein tether activity"], "types": ["T044"], "canonical_name": "cytoskeletal protein membrane tether activity"}
{"concept_id": "C5451024", "aliases": [], "types": ["T044"], "canonical_name": "polyketide syntase"}
{"concept_id": "C5451025", "aliases": [], "types": ["T044"], "canonical_name": "DIF-1 syntase"}
{"concept_id": "C5451026", "aliases": [], "types": ["T043"], "canonical_name": "regulation of UDP-GlcNAc biosynthetic process"}
{"concept_id": "C5451027", "aliases": [], "types": ["T043"], "canonical_name": "regulation of UDP-N-acetylglucosamine anabolism"}
{"concept_id": "C5451028", "aliases": [], "types": ["T040"], "canonical_name": "regulation of UDP-N-acetylglucosamine biosynthesis"}
{"concept_id": "C5451029", "aliases": [], "types": ["T043"], "canonical_name": "regulation of UDP-N-acetylglucosamine formation"}
{"concept_id": "C5451030", "aliases": [], "types": ["T043"], "canonical_name": "regulation of UDP-N-acetylglucosamine synthesis"}
{"concept_id": "C5451031", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of UDP-GlcNAc biosynthesis"}
{"concept_id": "C5451032", "aliases": ["negative regulation of UDP-GlcNAc biosynthetic process"], "types": ["T043"], "canonical_name": "negative regulation of UDP-N-acetylglucosamine biosynthetic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process. [PMID:32579556]"}
{"concept_id": "C5451033", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of UDP-N-acetylglucosamine anabolism"}
{"concept_id": "C5451034", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of UDP-N-acetylglucosamine biosynthesis"}
{"concept_id": "C5451035", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of UDP-N-acetylglucosamine formation"}
{"concept_id": "C5451036", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of UDP-N-acetylglucosamine synthesis"}
{"concept_id": "C5451037", "aliases": [], "types": ["T040"], "canonical_name": "positive egulation of UDP-N-acetylglucosamine formation"}
{"concept_id": "C5451038", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of UDP-GlcNAc biosynthetic process"}
{"concept_id": "C5451039", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of UDP-N-acetylglucosamine anabolism"}
{"concept_id": "C5451040", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of UDP-N-acetylglucosamine biosynthesis"}
{"concept_id": "C5451041", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of UDP-N-acetylglucosamine synthesis"}
{"concept_id": "C5451042", "aliases": [], "types": ["T043"], "canonical_name": "beta-1,2-mannan metabolic process"}
{"concept_id": "C5451043", "aliases": [], "types": ["T043"], "canonical_name": "mannogen metabolism"}
{"concept_id": "C5451044", "aliases": [], "types": ["T043"], "canonical_name": "beta-1,2-mannan biosynthetic process"}
{"concept_id": "C5451045", "aliases": [], "types": ["T043"], "canonical_name": "mannogen anabolism"}
{"concept_id": "C5451046", "aliases": [], "types": ["T043"], "canonical_name": "mannogen biosynthesis"}
{"concept_id": "C5451047", "aliases": [], "types": ["T043"], "canonical_name": "mannogen formation"}
{"concept_id": "C5451048", "aliases": [], "types": ["T043"], "canonical_name": "mannogen synthesis"}
{"concept_id": "C5451049", "aliases": [], "types": ["T043"], "canonical_name": "beta-1,2-mannan catabolic process"}
{"concept_id": "C5451050", "aliases": [], "types": ["T043"], "canonical_name": "beta-1,2-mannan catabolism"}
{"concept_id": "C5451051", "aliases": [], "types": ["T043"], "canonical_name": "mannogen breakdown"}
{"concept_id": "C5451052", "aliases": [], "types": ["T043"], "canonical_name": "mannogen catabolism"}
{"concept_id": "C5451053", "aliases": [], "types": ["T043"], "canonical_name": "mannogen degradation"}
{"concept_id": "C5451054", "aliases": ["SCMC", "subcortical maternal complex location"], "types": ["T026"], "canonical_name": "subcortical maternal complex", "definition": "Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex. [PMID:18804437, PMID:28992324]"}
{"concept_id": "C5451055", "aliases": ["3'-dRP lyase activity", "3'-dRP lyase"], "types": ["T044"], "canonical_name": "3'-deoxyribose phosphate lyase activity", "definition": "Catalysis of the conversion of a 3'-deoxyribose phosphate in DNA to a 3'-phosphate. [GOC:mah, PMID:21276450, PMID:22084197, PMID:22375014, RHEA:65764]"}
{"concept_id": "C5451056", "aliases": ["YSL development"], "types": ["T043"], "canonical_name": "yolk syncytial layer development", "definition": "The progression of the yolk syncytial layer over time, from its initial formation to the mature structure. The yolk syncytial layer is the peripheral layer of the yolk cell including nuclei and non-yolky cytoplasm. [PMID:29180571]"}
{"concept_id": "C5451069", "aliases": ["ODA docking complex location", "outer dynein arm docking complex location", "ODA-DC", "ODA docking complex"], "types": ["T026"], "canonical_name": "outer dynein arm docking complex", "definition": "A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules. [GOC:krc, PMID:15064350, PMID:24067530, PMID:25192045, PMID:27486780, PMID:8045937]"}
{"concept_id": "C5451070", "aliases": [], "types": ["T026"], "canonical_name": "auditory hair cell glycocalyx"}
{"concept_id": "C5451071", "aliases": [], "types": ["T043"], "canonical_name": "regulation of N-terminal signal peptide-independent translocation into the ER"}
{"concept_id": "C5451072", "aliases": [], "types": ["T043"], "canonical_name": "regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation"}
{"concept_id": "C5451073", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of N-terminal signal peptide-independent translocation into the ER"}
{"concept_id": "C5451074", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation"}
{"concept_id": "C5451075", "aliases": [], "types": ["T044"], "canonical_name": "2-iminobutanoate deaminase"}
{"concept_id": "C5451076", "aliases": [], "types": ["T044"], "canonical_name": "2-iminopropanoate deaminase"}
{"concept_id": "C5451077", "aliases": [], "types": ["T044"], "canonical_name": "enamine/imine deaminase"}
{"concept_id": "C5451078", "aliases": [], "types": ["T044"], "canonical_name": "imine intermediate deaminase activity"}
{"concept_id": "C5451079", "aliases": ["2-iminobutanoate/2-iminopropanoate deaminase"], "types": ["T044"], "canonical_name": "2-iminobutanoate/2-iminopropanoate deaminase", "definition": "Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17. [EC:3.5.99.10]"}
{"concept_id": "C5451080", "aliases": ["outer hair cell lateral wall", "OHC lateral wall", "lateral wall of OHC"], "types": ["T026"], "canonical_name": "lateral wall of outer hair cell", "definition": "The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae. [GOC:krc, PMID:26352669, PMID:31920560, PMID:9412485]"}
{"concept_id": "C5451081", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of heterochromatin organization"}
{"concept_id": "C5451082", "aliases": [], "types": ["T043"], "canonical_name": "activation of heterochromatin organization"}
{"concept_id": "C5451083", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of heterochromatin organization"}
{"concept_id": "C5451084", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chromosome attachment to the nuclear envelope"}
{"concept_id": "C5451085", "aliases": [], "types": ["T043"], "canonical_name": "activation of chromosome attachment to the nuclear envelope"}
{"concept_id": "C5451086", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of chromosome attachment to the nuclear envelope"}
{"concept_id": "C5451087", "aliases": ["PFR assembly", "paraflagellar rod biogenesis", "paraflagellar rod formation"], "types": ["T043"], "canonical_name": "paraflagellar rod assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. [GOC:ach, GOC:krc, PMID:23787017, PMID:32295845]"}
{"concept_id": "C5451088", "aliases": [], "types": ["T043"], "canonical_name": "ciliary centrin arm formation"}
{"concept_id": "C5451089", "aliases": [], "types": ["T039"], "canonical_name": "activation of cerebral blood circulation"}
{"concept_id": "C5451090", "aliases": [], "types": ["T039"], "canonical_name": "inhibition of cerebral blood circulation"}
{"concept_id": "C5451091", "aliases": [], "types": ["T026"], "canonical_name": "pro-basal body"}
{"concept_id": "C5451092", "aliases": [], "types": ["T026"], "canonical_name": "pro-centriole"}
{"concept_id": "C5451093", "aliases": [], "types": ["T026"], "canonical_name": "probasal body"}
{"concept_id": "C5451094", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of homologous recombination dependent replication fork recovery"}
{"concept_id": "C5451095", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to latrunculin A"}
{"concept_id": "C5451096", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to latrunculin B"}
{"concept_id": "C5451097", "aliases": [], "types": ["T043"], "canonical_name": "response to latrunculin A"}
{"concept_id": "C5451098", "aliases": [], "types": ["T043"], "canonical_name": "response to latrunculin B"}
{"concept_id": "C5451099", "aliases": [], "types": ["T043"], "canonical_name": "outer doublet assembly"}
{"concept_id": "C5451100", "aliases": [], "types": ["T043"], "canonical_name": "outer-doublet microtubule assembly"}
{"concept_id": "C5451101", "aliases": [], "types": ["T043"], "canonical_name": "flagellar pro-basal body maturation"}
{"concept_id": "C5451102", "aliases": [], "types": ["T043"], "canonical_name": "flagellar probasal body maturation"}
{"concept_id": "C5451103", "aliases": [], "types": ["T043"], "canonical_name": "pro-basal body maturation"}
{"concept_id": "C5451104", "aliases": ["ciliary basal body separation"], "types": ["T043"], "canonical_name": "ciliary basal body segregation", "definition": "The process in which the duplicated basal bodies migrate in pairs to the mitotic poles of the nucleus and results in equal distribution in the daughter cells. Ciliary basal body segregation ensures inheritance of the duplicated mitochondrial DNA to the two daughter cells in the Trypanosoma parasites. [GOC:ach, GOC:krc, PMID:1876188, PMID:26272611, PMID:26862392, PMID:27252853, PMID:4055898]"}
{"concept_id": "C5451105", "aliases": ["microtubule basal body segregation"], "types": ["T043"], "canonical_name": "microtubule basal body separation"}
{"concept_id": "C5451106", "aliases": [], "types": ["T045"], "canonical_name": "activating transcription factor binding"}
{"concept_id": "C5451107", "aliases": [], "types": ["T045"], "canonical_name": "repressing transcription factor binding"}
{"concept_id": "C5451108", "aliases": [], "types": ["T045"], "canonical_name": "transcription activator binding"}
{"concept_id": "C5451109", "aliases": [], "types": ["T044"], "canonical_name": "translocase activity"}
{"concept_id": "C5451110", "aliases": [], "types": ["T043"], "canonical_name": "correction of merotelic kinetochore attachment, mitotic"}
{"concept_id": "C5451111", "aliases": [], "types": ["T043"], "canonical_name": "correction of mono-orientation defects"}
{"concept_id": "C5451112", "aliases": [], "types": ["T043"], "canonical_name": "correction of syntelic kinetochore attachment, mitotic"}
{"concept_id": "C5451113", "aliases": ["repair of mitotic merotelic kinetochore attachment defect"], "types": ["T043"], "canonical_name": "repair of mitotic merotelic kinetochore attachment defects"}
{"concept_id": "C5451114", "aliases": ["repair of mitotic mono-orientation defect"], "types": ["T043"], "canonical_name": "repair of mitotic mono-orientation defects"}
{"concept_id": "C5451115", "aliases": [], "types": ["T043"], "canonical_name": "interleukin maturation"}
{"concept_id": "C5451116", "aliases": [], "types": ["T043"], "canonical_name": "interleukin processing"}
{"concept_id": "C5451117", "aliases": [], "types": ["T044"], "canonical_name": "chromatin recruitment"}
{"concept_id": "C5451118", "aliases": [], "types": ["T044"], "canonical_name": "regulation of eIF2 alpha phosphorylation by amino acid starvation"}
{"concept_id": "C5451119", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of transmigration of symbiont in host"}
{"concept_id": "C5451120", "aliases": [], "types": ["T044"], "canonical_name": "ATPase-coupled iron-sulfur cluster transmembrane transporter activity"}
{"concept_id": "C5451121", "aliases": [], "types": ["T044"], "canonical_name": "inner kinetochore adaptor activity"}
{"concept_id": "C5451122", "aliases": [], "types": ["T044"], "canonical_name": "outer kinetochore adaptor activity"}
{"concept_id": "C5451123", "aliases": [], "types": ["T043"], "canonical_name": "regulation of endoplasmic reticulum degradation"}
{"concept_id": "C5451124", "aliases": [], "types": ["T043"], "canonical_name": "regulation of ER degradation"}
{"concept_id": "C5451125", "aliases": ["positive regulation of endoplasmic reticulum degradation"], "types": ["T043"], "canonical_name": "positive regulation of ER degradation"}
{"concept_id": "C5451126", "aliases": [], "types": ["T043"], "canonical_name": "granzyme-mediated cell death signaling pathway"}
{"concept_id": "C5451127", "aliases": [], "types": ["T026"], "canonical_name": "nuclear bridge"}
{"concept_id": "C5451128", "aliases": [], "types": ["T045"], "canonical_name": "nuclear corepressor activity"}
{"concept_id": "C5451129", "aliases": [], "types": ["T026"], "canonical_name": "spore membrane"}
{"concept_id": "C5451130", "aliases": ["TEAD-1-YAP complex location"], "types": ["T026"], "canonical_name": "TEAD-1-YAP complex"}
{"concept_id": "C5451131", "aliases": ["TEAD-2 multiprotein complex location"], "types": ["T026"], "canonical_name": "TEAD-2 multiprotein complex"}
{"concept_id": "C5451132", "aliases": ["TEAD-2-YAP complex location"], "types": ["T026"], "canonical_name": "TEAD-2-YAP complex"}
{"concept_id": "C5451133", "aliases": ["TEAD-3-YAP complex location"], "types": ["T026"], "canonical_name": "TEAD-3-YAP complex"}
{"concept_id": "C5451134", "aliases": ["TEAD-4-YAP complex location"], "types": ["T026"], "canonical_name": "TEAD-4-YAP complex"}
{"concept_id": "C5451135", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane helix dislocase"}
{"concept_id": "C5451136", "aliases": ["cellular ascorbate homeostasis"], "types": ["T043"], "canonical_name": "ascorbate homeostasis", "definition": "Any process involved in the maintenance of an internal steady state of ascorbate at the level of a cell. [PMID:1623014, PMID:17068337, PMID:32547589]"}
{"concept_id": "C5451137", "aliases": [], "types": ["T045"], "canonical_name": "chromatin folding"}
{"concept_id": "C5451138", "aliases": [], "types": ["T044"], "canonical_name": "protein chaperone"}
{"concept_id": "C5451143", "aliases": [], "types": ["T044"], "canonical_name": "caspase activator activator activity"}
{"concept_id": "C5451144", "aliases": [], "types": ["T044"], "canonical_name": "iodide peroxidase-tyrosine iodinase activity"}
{"concept_id": "C5451145", "aliases": [], "types": ["T044"], "canonical_name": "iodotyrosine deiodase activity"}
{"concept_id": "C5451146", "aliases": [], "types": ["T044"], "canonical_name": "iodotyrosine deiodinase activity", "definition": "Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates. [PMID:15289438, PMID:18434651, PMID:25395621, PMID:27643701, RHEA:32479]"}
{"concept_id": "C5451147", "aliases": [], "types": ["T044"], "canonical_name": "monoiodotyrosine deiodinase activity"}
{"concept_id": "C5451148", "aliases": [], "types": ["T044"], "canonical_name": "tyrosine iodinase activity"}
{"concept_id": "C5451149", "aliases": ["T1P assembly", "type I fimbrial biogenesis", "type I fimbrium assembly", "type I fimbriae biogenesis", "type I fimbria assembly", "type I fimbrial assembly", "type I fimbrium biogenesis", "type I fimbria biogenesis", "type 1 pilus biogenesis", "type I fimbriae assembly"], "types": ["T043"], "canonical_name": "type I pilus assembly", "definition": "The assembly from its constituent parts of a type I pilus. [PMID:1679330]"}
{"concept_id": "C5451150", "aliases": [], "types": ["T044"], "canonical_name": "met-enkephalin receptor activity"}
{"concept_id": "C5451151", "aliases": [], "types": ["T044"], "canonical_name": "metenkefalin receptor activity"}
{"concept_id": "C5451152", "aliases": ["small ribosomal subunit maturation complex location"], "types": ["T026"], "canonical_name": "small ribosomal subunit maturation complex"}
{"concept_id": "C5451153", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-33 biosynthetic process"}
{"concept_id": "C5451154", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-33 secretion"}
{"concept_id": "C5451155", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-33 biosynthetic process"}
{"concept_id": "C5451156", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-33 secretion"}
{"concept_id": "C5451157", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-33 biosynthetic process"}
{"concept_id": "C5451158", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-33 secretion"}
{"concept_id": "C5451159", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-34 biosynthetic process"}
{"concept_id": "C5451160", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-34 biosynthetic process"}
{"concept_id": "C5451161", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-34 biosynthetic process"}
{"concept_id": "C5451162", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-34 biosynthetic process"}
{"concept_id": "C5451163", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-32 secretion"}
{"concept_id": "C5451164", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-32 secretion"}
{"concept_id": "C5451165", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-32 secretion"}
{"concept_id": "C5451166", "aliases": ["regulation of defense response to fungus, incompatible interaction"], "types": ["T040"], "canonical_name": "regulation of defense response to fungi, incompatible interaction"}
{"concept_id": "C5451167", "aliases": ["regulation of resistance response to pathogenic fungus"], "types": ["T040"], "canonical_name": "regulation of resistance response to pathogenic fungi"}
{"concept_id": "C5451168", "aliases": [], "types": ["T040"], "canonical_name": "regulation of response to pathogenic fungus (incompatible interaction)"}
{"concept_id": "C5451169", "aliases": ["regulation of defense response to bacterium, incompatible interaction"], "types": ["T046"], "canonical_name": "regulation of defence response to bacterium, incompatible interaction"}
{"concept_id": "C5451170", "aliases": ["regulation of defence response to pathogenic bacterium, incompatible interaction"], "types": ["T046"], "canonical_name": "regulation of defence response to pathogenic bacteria, incompatible interaction"}
{"concept_id": "C5451171", "aliases": ["regulation of resistance response to pathogenic bacterium"], "types": ["T046"], "canonical_name": "regulation of resistance response to pathogenic bacteria"}
{"concept_id": "C5451172", "aliases": ["inhibition of defence response to pathogenic bacterium, incompatible interaction"], "types": ["T046"], "canonical_name": "inhibition of defence response to pathogenic bacteria, incompatible interaction"}
{"concept_id": "C5451173", "aliases": [], "types": ["T046"], "canonical_name": "inhibition of defense response to bacterium, incompatible interaction"}
{"concept_id": "C5451174", "aliases": ["inhibition of resistance response to pathogenic bacterium"], "types": ["T046"], "canonical_name": "inhibition of resistance response to pathogenic bacteria"}
{"concept_id": "C5451175", "aliases": ["inhibition of response to pathogenic bacterium (incompatible interaction)"], "types": ["T046"], "canonical_name": "inhibition of response to pathogenic bacteria (incompatible interaction)"}
{"concept_id": "C5451176", "aliases": [], "types": ["T046"], "canonical_name": "negative regulation of defense response to bacterium, incompatible interaction"}
{"concept_id": "C5451177", "aliases": ["activation of resistance response to pathogenic bacterium"], "types": ["T040"], "canonical_name": "activation of resistance response to pathogenic bacteria"}
{"concept_id": "C5451178", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of defense response to bacterium, incompatible interaction"}
{"concept_id": "C5451179", "aliases": [], "types": ["T044"], "canonical_name": "naphthalene metabolic process"}
{"concept_id": "C5451180", "aliases": [], "types": ["T044"], "canonical_name": "naphthalene metabolism"}
{"concept_id": "C5451181", "aliases": [], "types": ["T043"], "canonical_name": "sequestration of proteasome core complex in proteasome storage granule"}
{"concept_id": "C5451182", "aliases": [], "types": ["T045"], "canonical_name": "initiation of meiotic DNA synthesis"}
{"concept_id": "C5451183", "aliases": ["premeiotic DNA replication initiation"], "types": ["T045"], "canonical_name": "initiation of premeiotic DNA replication"}
{"concept_id": "C5451184", "aliases": [], "types": ["T045"], "canonical_name": "initiation of premeiotic DNA synthesis"}
{"concept_id": "C5451185", "aliases": [], "types": ["T040"], "canonical_name": "modulation of spore germination on or near host"}
{"concept_id": "C5451186", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of spore germination on or near host"}
{"concept_id": "C5451187", "aliases": [], "types": ["T043"], "canonical_name": "correction of merotelic kinetochore attachment, meiosis I"}
{"concept_id": "C5451188", "aliases": [], "types": ["T043"], "canonical_name": "repair of merotelic kinetochore attachment defect, meiosis I"}
{"concept_id": "C5451189", "aliases": [], "types": ["T040"], "canonical_name": "EDN1 production"}
{"concept_id": "C5451190", "aliases": ["endothelin-2 production"], "types": ["T040"], "canonical_name": "EDN2 production"}
{"concept_id": "C5451191", "aliases": ["endothelin-3 production"], "types": ["T040"], "canonical_name": "EDN3 production"}
{"concept_id": "C5451192", "aliases": [], "types": ["T043"], "canonical_name": "microtubule sliding involved in mitotic metaphase chromosome recapture"}
{"concept_id": "C5451193", "aliases": [], "types": ["T040"], "canonical_name": "chemokine (C-C motif) ligand 2 secretion"}
{"concept_id": "C5451194", "aliases": ["regulation of chemokine (C-C motif) ligand 2 secretion"], "types": ["T040"], "canonical_name": "regulation of CCL2 secretion"}
{"concept_id": "C5451195", "aliases": ["inhibition of chemokine (C-C motif) ligand 2 secretion"], "types": ["T040"], "canonical_name": "inhibition of CCL2 secretion"}
{"concept_id": "C5451196", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of chemokine (C-C motif) ligand 2 secretion"}
{"concept_id": "C5451197", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of chemokine (C-C motif) ligand 2 secretion"}
{"concept_id": "C5451198", "aliases": [], "types": ["T040"], "canonical_name": "IL17E secretion"}
{"concept_id": "C5451199", "aliases": ["nuclear condensin complex location"], "types": ["T026"], "canonical_name": "nuclear condensin complex"}
{"concept_id": "C5451200", "aliases": [], "types": ["T044"], "canonical_name": "xanthine oxidation"}
{"concept_id": "C5451201", "aliases": [], "types": ["T044"], "canonical_name": "shikimate synthesis"}
{"concept_id": "C5451202", "aliases": [], "types": ["T039"], "canonical_name": "positive regulation of spore germination on or near host"}
{"concept_id": "C5451203", "aliases": [], "types": ["T026"], "canonical_name": "nuclear pericentric heterochromatin"}
{"concept_id": "C5451207", "aliases": ["ATP-independent citrate lyase complex location"], "types": ["T026"], "canonical_name": "ATP-independent citrate lyase complex", "definition": "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. This enzyme has only been found in bacteria. [PMID:32302313]"}
{"concept_id": "C5451208", "aliases": ["EMC complex location"], "types": ["T026"], "canonical_name": "EMC complex", "definition": "A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. [PMID:29242231, PMID:30415835, PMID:32459176]"}
{"concept_id": "C5451209", "aliases": ["mitochondrial protein-containing complex location"], "types": ["T026"], "canonical_name": "mitochondrial protein-containing complex", "definition": "A protein complex that is part of a mitochondrion. [GOC:dos]"}
{"concept_id": "C5451210", "aliases": ["DNA recombinase activator complex location", "DNA recombinase accessory factor complex", "DNA recombinase auxiliary factor complex location", "DNA recombinase accessory factor complex location", "DNA recombinase activator complex"], "types": ["T026"], "canonical_name": "DNA recombinase auxiliary factor complex", "definition": "A protein complex that binds to a recombinase and incrseases its activity. [PMID:32414915]"}
{"concept_id": "C5451211", "aliases": ["snRNP 7SK", "7SK snRNP location", "snRNP 7SK location"], "types": ["T026"], "canonical_name": "7SK snRNP", "definition": "A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb. [PMID:18249148, PMID:28431135]"}
{"concept_id": "C5451212", "aliases": ["mannan polymerase II complex location"], "types": ["T026"], "canonical_name": "mannan polymerase II complex", "definition": "A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p. [PMID:9430634]"}
{"concept_id": "C5451213", "aliases": ["mannan polymerase I complex location"], "types": ["T026"], "canonical_name": "mannan polymerase I complex", "definition": "A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the priming and elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p and Van1p. [PMID:9430634]"}
{"concept_id": "C5451214", "aliases": ["nuclear complex location", "nuclear complex", "nuclear protein-containing complex location"], "types": ["T026"], "canonical_name": "nuclear protein-containing complex", "definition": "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. [GOC:pg]"}
{"concept_id": "C5451215", "aliases": ["endoplasmic reticulum protein-containing complex location"], "types": ["T026"], "canonical_name": "endoplasmic reticulum protein-containing complex", "definition": "A protein complex that is part of an endoplasmic reticulum. [GOC:pg]"}
{"concept_id": "C5451216", "aliases": ["intracellular protein-containing complex location"], "types": ["T026"], "canonical_name": "intracellular protein-containing complex", "definition": "A protein-containing complex located intracellularly. [GOC:pg]"}
{"concept_id": "C5451217", "aliases": ["TEAD-YAP complex location"], "types": ["T026"], "canonical_name": "TEAD-YAP complex", "definition": "A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP. [GOC:mah, PMID:11358867]"}
{"concept_id": "C5451218", "aliases": ["ER-to-endosome phospholipid transfer complex location"], "types": ["T026"], "canonical_name": "ER-to-endosome phospholipid transfer complex", "definition": "Lipid transfer complex that is responsible for the non-vesicular transport of phospholipids, such as phosphatidylserine, from the endoplasmic reticulum to the endosome. It resides in the endosomal (acceptor) membrane and binds to specific lipids on the donor membrane at the ER-endosome contact site. [GOC:lnp, PMID:20016005, PMID:24366873]"}
{"concept_id": "C5451219", "aliases": ["CARD8 inflammasome complex location"], "types": ["T026"], "canonical_name": "CARD8 inflammasome complex", "definition": "An inflammasome complex that consists of CARD8 and CASP1. [PMID:33420028, PMID:33420033, PMID:33542150]"}
{"concept_id": "C5451220", "aliases": ["small ribosomal subunit processing complex location"], "types": ["T026"], "canonical_name": "small ribosomal subunit processing complex", "definition": "A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of Rcl1p and Bms1p. [GOC:lnp, PMID:21849504, PMID:25064857]"}
{"concept_id": "C5451233", "aliases": ["box C/D RNA 3' end processing"], "types": ["T045"], "canonical_name": "box C/D RNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of a box C/D RNA molecule. [GOC:krc]"}
{"concept_id": "C5451234", "aliases": ["box H/ACA RNA 3' end processing"], "types": ["T045"], "canonical_name": "box H/ACA RNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of a box H/ACA RNA molecule. [GOC:krc]"}
{"concept_id": "C5451235", "aliases": [], "types": ["T045"], "canonical_name": "transcription regulatory region nucleic acid binding", "definition": "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. [GOC:txnOH]"}
{"concept_id": "C5451236", "aliases": [], "types": ["T045"], "canonical_name": "transcription coregulator binding", "definition": "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. [GOC:krc]"}
{"concept_id": "C5451237", "aliases": ["signaling G protein activity"], "types": ["T044"], "canonical_name": "G protein activity", "definition": "A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). [PMID:16923326, PMID:24470015]"}
{"concept_id": "C5451238", "aliases": [], "types": ["T044"], "canonical_name": "biliverdin reductase (NAD(P)+) activity", "definition": "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+. [EC:1.3.1.24]"}
{"concept_id": "C5451239", "aliases": [], "types": ["T044"], "canonical_name": "NAD-retinol dehydrogenase activity", "definition": "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. [RHEA:21284]"}
{"concept_id": "C5451240", "aliases": [], "types": ["T044"], "canonical_name": "G protein-coupled opioid receptor activity", "definition": "Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein. [GOC:ai, GOC:bf, PMID:20494127]"}
{"concept_id": "C5451241", "aliases": [], "types": ["T043"], "canonical_name": "mitotic nuclear membrane reassembly", "definition": "The mitotic cell cycle process involving ESCRTIII that results in reformation of the nuclear envelope after mitotic nuclear division. In organisms undergoing closed mitosis this involves resealing or 'repair' of the nuclear envelope in the nuclear bridge. [PMID:26040712, PMID:28242692, PMID:32109380, PMID:32848252]"}
{"concept_id": "C5451242", "aliases": [], "types": ["T043"], "canonical_name": "regulation of synaptic assembly at neuromuscular junction", "definition": "Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions. [GOC:go_curators]"}
{"concept_id": "C5451243", "aliases": [], "types": ["T045"], "canonical_name": "sno(s)RNA transcription", "definition": "The synthesis of snoRNA class RNA (also referred to as sRNA in Archaea) from a DNA template. [GOC:jl, GOC:krc, PMID:17284456]"}
{"concept_id": "C5451244", "aliases": ["undecaprenol-pyrophosphate O-antigen flippase activity"], "types": ["T044"], "canonical_name": "lipid III floppase activity", "definition": "Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi. [GOC:ai, GOC:mtg_transport, PMID:12621029, PMID:16816184]"}
{"concept_id": "C5451245", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type polyamine transporter activity", "definition": "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). [RHEA:29999]"}
{"concept_id": "C5451246", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type bile acid transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate. [RHEA:50048]"}
{"concept_id": "C5451247", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type putrescine transporter activity", "definition": "Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in). [EC:7.6.2.11]"}
{"concept_id": "C5451248", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type D-ribose transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in). [RHEA:29903]"}
{"concept_id": "C5451249", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type D-xylose transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) -> ADP + phosphate + D-xylose(in). [RHEA:29899]"}
{"concept_id": "C5451250", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type zinc transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in). [RHEA:29795]"}
{"concept_id": "C5451251", "aliases": [], "types": ["T045"], "canonical_name": "sno(s)RNA metabolic process", "definition": "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. [GOC:krc]"}
{"concept_id": "C5451252", "aliases": ["sno(s)RNA catabolism", "sno(s)RNA degradation", "sno(s)RNA breakdown"], "types": ["T045"], "canonical_name": "sno(s)RNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. [GOC:krc, ISBN:0198506732]"}
{"concept_id": "C5451253", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)H oxidase H2O2-forming activity", "definition": "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. [EC:1.6.3.1, PMID:10401672, PMID:10601291, PMID:11822874, RHEA:11260]"}
{"concept_id": "C5451254", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on metal ions", "definition": "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. [GOC:mah]"}
{"concept_id": "C5451255", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor", "definition": "Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor. [GOC:mah]"}
{"concept_id": "C5451256", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on metal ions, oxygen as acceptor", "definition": "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor. [GOC:mah]"}
{"concept_id": "C5451257", "aliases": [], "types": ["T044"], "canonical_name": "signaling receptor regulator activity", "definition": "Binds to and modulates the activity of a receptor. [GOC:ceb]"}
{"concept_id": "C5451258", "aliases": [], "types": ["T044"], "canonical_name": "signaling receptor inhibitor activity", "definition": "Binds to and modulates the activity of a signaling receptor. [GOC:ceb]"}
{"concept_id": "C5451259", "aliases": ["sno(s)RNA 3' end processing"], "types": ["T045"], "canonical_name": "sno(s)RNA 3'-end processing", "definition": "Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea. [GOC:krc, GOC:mah, PMID:17284456]"}
{"concept_id": "C5451260", "aliases": [], "types": ["T043"], "canonical_name": "nuclear membrane reassembly", "definition": "The reformation of the nuclear membranes following their breakdown in the context of a normal process. [GOC:mah]"}
{"concept_id": "C5451261", "aliases": [], "types": ["T043"], "canonical_name": "mitotic cell size control checkpoint signaling", "definition": "A signal transduction process that contributes to a cell size control checkpoint during mitosis. [GOC:mtg_cell_cycle]"}
{"concept_id": "C5451262", "aliases": [], "types": ["T044"], "canonical_name": "P-type cobalt transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in). [GOC:mlg, GOC:mtg_transport, ISBN:0815340729]"}
{"concept_id": "C5451263", "aliases": ["glycolipid 6-alpha-mannosyltransferase activity"], "types": ["T044"], "canonical_name": "glycolipid 1,6-alpha-mannosyltransferase activity", "definition": "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage. [GOC:mcc, PMID:16878994]"}
{"concept_id": "C5451264", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type D-methionine transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out). [GOC:mlg, PMID:12169620, PMID:12819857, PMID:18621668, RHEA:29779]"}
{"concept_id": "C5451265", "aliases": ["ABC-type choline transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type choline transporter activity", "definition": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane. [GOC:mlg]"}
{"concept_id": "C5451266", "aliases": [], "types": ["T045"], "canonical_name": "box C/D RNA metabolic process", "definition": "The chemical reactions and pathways involving box C/D type small nucleolar RNA. [GOC:krc, GOC:mah]"}
{"concept_id": "C5451267", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA RNA metabolic process", "definition": "The chemical reactions and pathways involving box H/ACA type small nucleolar RNA. [GOC:krc, GOC:mah]"}
{"concept_id": "C5451268", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type sterol transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out). [GOC:BHF, GOC:rl]"}
{"concept_id": "C5451269", "aliases": [], "types": ["T045"], "canonical_name": "box C/D RNA binding", "definition": "Binding to a box C/D small nucleolar RNA. [GOC:mah]"}
{"concept_id": "C5451270", "aliases": [], "types": ["T045"], "canonical_name": "box C/D RNA processing", "definition": "Any process involved in the conversion of a primary box C/D type small RNA transcript into a mature box C/D RNA. [GOC:krc, GOC:mah]"}
{"concept_id": "C5451271", "aliases": [], "types": ["T045"], "canonical_name": "box H/ACA RNA processing", "definition": "Any process involved in the conversion of a primary box H/ACA type small RNA transcript into a mature box H/ACA RNA. [GOC:krc, GOC:mah]"}
{"concept_id": "C5451272", "aliases": [], "types": ["T045"], "canonical_name": "intronic box C/D RNA processing", "definition": "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA. [GOC:krc, GOC:mah]"}
{"concept_id": "C5451273", "aliases": [], "types": ["T044"], "canonical_name": "pheophorbidase activity", "definition": "Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a. [PMID:16228561, RHEA:32483]"}
{"concept_id": "C5451275", "aliases": [], "types": ["T044"], "canonical_name": "G protein-coupled enkephalin receptor activity", "definition": "Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body. [GOC:bf, Wikipedia:Enkephalin]"}
{"concept_id": "C5451276", "aliases": ["sno(s)RNA 3' end cleavage"], "types": ["T045"], "canonical_name": "sno(s)RNA 3'-end cleavage", "definition": "The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional. [GOC:go_curators, PMID:12773397]"}
{"concept_id": "C5451277", "aliases": [], "types": ["T044"], "canonical_name": "carbohydrate-exporting ABC transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out). [GOC:mlg]"}
{"concept_id": "C5451278", "aliases": [], "types": ["T044"], "canonical_name": "P-type divalent copper transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out). [RHEA:10376]"}
{"concept_id": "C5451279", "aliases": [], "types": ["T044"], "canonical_name": "oxidoreductase activity, acting on metal ions, flavin as acceptor", "definition": "Catalysis of an oxidation-reduction in which the metal ion is reduced and flavin acts as an electron acceptor. [EC:1.16.8.-]"}
{"concept_id": "C5451280", "aliases": ["regulation of symbiotic process"], "types": ["T040"], "canonical_name": "regulation of biological process involved in symbiotic interaction", "definition": "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. [GOC:jl]"}
{"concept_id": "C5451281", "aliases": [], "types": ["T040"], "canonical_name": "formation of structure involved in a symbiotic process", "definition": "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction. [GO:jl, GOC:pamgo_curators]"}
{"concept_id": "C5451282", "aliases": [], "types": ["T040"], "canonical_name": "modulation of formation of structure involved in a symbiotic process", "definition": "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. [GOC:jl, GOC:pamgo_curators]"}
{"concept_id": "C5451283", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of formation of structure involved in a symbiotic process", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. [GOC:jl, GOC:pamgo_curators]"}
{"concept_id": "C5451284", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of formation of structure involved in a symbiotic process", "definition": "Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. [GOC:jl, GOC:pamgo_curators]"}
{"concept_id": "C5451285", "aliases": [], "types": ["T040"], "canonical_name": "biological process involved in symbiotic interaction", "definition": "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts. [GOC:cc, PMID:31257129]"}
{"concept_id": "C5451286", "aliases": ["GDNF production"], "types": ["T043"], "canonical_name": "glial cell-derived neurotrophic factor production", "definition": "The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons. [GOC:yaf, PMID:17505307]"}
{"concept_id": "C5451287", "aliases": ["ABC-type phytochelatin transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type phytochelatin transporter activity", "definition": "Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. [GOC:mah, PMID:1396551]"}
{"concept_id": "C5451288", "aliases": [], "types": ["T044"], "canonical_name": "15-cis-phytoene synthase activity", "definition": "Catalysis of the reaction: 2 geranylgeranyl diphosphate -> 15-cis-phytoene + 2 diphosphate. [GOC:ai, PMID:12641468, RHEA:34479]"}
{"concept_id": "C5451289", "aliases": [], "types": ["T044"], "canonical_name": "glyoxylate reductase (NAD+) activity", "definition": "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH. [RHEA:18229]"}
{"concept_id": "C5451290", "aliases": [], "types": ["T043"], "canonical_name": "meiotic nuclear membrane disassembly", "definition": "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs. [GOC:bf]"}
{"concept_id": "C5451291", "aliases": [], "types": ["T043"], "canonical_name": "meiosis I nuclear membrane disassembly", "definition": "The controlled breakdown of the nuclear membranes during the first division of meiosis. [GOC:bf]"}
{"concept_id": "C5451292", "aliases": [], "types": ["T043"], "canonical_name": "meiosis II nuclear membrane disassembly", "definition": "The controlled breakdown of the nuclear membranes during the second division of meiosis. [GOC:bf]"}
{"concept_id": "C5451293", "aliases": [], "types": ["T043"], "canonical_name": "synaptic assembly at neuromuscular junction", "definition": "The assembly of a synapse at a neuromuscular junction. [PMID:20215342]"}
{"concept_id": "C5451294", "aliases": [], "types": ["T043"], "canonical_name": "meiotic nuclear membrane reassembly", "definition": "The cell cycle process in which the reformation of the nuclear membranes during meiosis occurs. [GOC:ai]"}
{"concept_id": "C5451295", "aliases": [], "types": ["T043"], "canonical_name": "meiosis I nuclear membrane reassembly", "definition": "The reformation of the nuclear membranes during meiosis I. [GOC:ai]"}
{"concept_id": "C5451296", "aliases": [], "types": ["T043"], "canonical_name": "meiosis II nuclear membrane reassembly", "definition": "The reformation of the nuclear membrane during meiosis II. [GOC:ai]"}
{"concept_id": "C5451297", "aliases": [], "types": ["T040"], "canonical_name": "biological process involved in interaction with symbiont", "definition": "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. [GOC:cc]"}
{"concept_id": "C5451298", "aliases": [], "types": ["T040"], "canonical_name": "effector-mediated suppression of host pattern-triggered immunity", "definition": "A process mediated by a molecule secreted by a symbiont that results in the suppression of the innate immune response of the host organism via recognition of a microbe-associated molecular pattern. The innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mah]"}
{"concept_id": "C5451299", "aliases": [], "types": ["T044"], "canonical_name": "ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide", "definition": "The pathway resulting in the formation of ergothioneine from histidine via a set of steps in which gamma-glutamyl-hercynylcysteine sulfoxide is formed as an intermediate. [PMID:4276459, PMID:5484456]"}
{"concept_id": "C5451300", "aliases": [], "types": ["T045"], "canonical_name": "topological DNA co-entrapment activity", "definition": "A DNA binding activity in which a protein complex interacts with more than one DNA duplex to encircle the DNA molecules with a loose fitting ring. [GOC:dph, GOC:vw, PMID:16179255, PMID:26687354, PMID:27797071]"}
{"concept_id": "C5451301", "aliases": [], "types": ["T040"], "canonical_name": "cleistothecium formation", "definition": "The process of producing a cleistothecium, a closed sexual fruiting body that contains ascospores in linear asci. Cleistothecia are present in some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. [PMID:20348388, PMID:28889020, PMID:30410052]"}
{"concept_id": "C5451302", "aliases": [], "types": ["T043"], "canonical_name": "dentin extracellular matrix secretion", "definition": "The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin. [GOC:mah, PMID:12856968]"}
{"concept_id": "C5451304", "aliases": [], "types": ["T045"], "canonical_name": "sno(s)RNA polyadenylation", "definition": "The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA class molecule (referred to as an sRNA in Archaea). In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation. [GOC:dgf, GOC:krc, PMID:18951092]"}
{"concept_id": "C5451305", "aliases": ["formation of host infection structure"], "types": ["T040"], "canonical_name": "formation of infection structure", "definition": "The formation of a symbiont structure that serves to infect its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C5451307", "aliases": [], "types": ["T042"], "canonical_name": "spore encystment", "definition": "The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:kmv, GOC:pamgo_curators]"}
{"concept_id": "C5451308", "aliases": [], "types": ["T040"], "canonical_name": "regulation of sporangium germination", "definition": "Any process that modulates the frequency, rate or extent of sporangium germination. [GOC:pamgo_curators]"}
{"concept_id": "C5451309", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of sporangium germination", "definition": "Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination. [GOC:pamgo_curators]"}
{"concept_id": "C5451310", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of sporangium germination", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium germination. [GOC:pamgo_curators]"}
{"concept_id": "C5451311", "aliases": [], "types": ["T040"], "canonical_name": "formation of arbuscule for nutrient acquisition", "definition": "The assembly of an arbuscule, a fine, tree-like hyphal symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C5451312", "aliases": [], "types": ["T040"], "canonical_name": "formation of stylet for nutrient acquisition", "definition": "The assembly of a stylet, a hollow protrusible spear-like symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:pamgo_curators]"}
{"concept_id": "C5451313", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cell migration involved in somitogenic axis elongation", "definition": "Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation. [GOC:ascb_2009, GOC:dph, GOC:tb]"}
{"concept_id": "C5451314", "aliases": [], "types": ["T044"], "canonical_name": "acyl-lipid omega-(9-4) desaturase", "definition": "Catalysis of the reaction: linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H(+) <=> pinolenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O. [GOC:pz, RHEA:46236]"}
{"concept_id": "C5451315", "aliases": ["dsDNA bridging", "double-stranded DNA bridging"], "types": ["T045"], "canonical_name": "DNA-DNA tethering activity", "definition": "Bridging together two regions of a DNA molecule. [PMID:29358048, PMID:30626735]"}
{"concept_id": "C5451316", "aliases": [], "types": ["T044"], "canonical_name": "tRNA uridine(34) acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine. [PMID:25151136, PMID:30733442, RHEA:61020]"}
{"concept_id": "C5451317", "aliases": [], "types": ["T044"], "canonical_name": "1-acylglycerophosphoethanolamine O-acyltransferase activity", "definition": "Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA. [PMID:18287005, RHEA:32995]"}
{"concept_id": "C5451318", "aliases": [], "types": ["T044"], "canonical_name": "1-acylglycerophosphoserine O-acyltransferase activity", "definition": "Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA. [PMID:18287005, RHEA:33191]"}
{"concept_id": "C5451319", "aliases": [], "types": ["T044"], "canonical_name": "protein serine kinase activity (using GTP as donor)", "definition": "Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]. [GOC:sp, PMID:32322062, RHEA:64020]"}
{"concept_id": "C5451320", "aliases": [], "types": ["T044"], "canonical_name": "THPH synthase activity", "definition": "Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA. [PMID:9446571, RHEA:64352]"}
{"concept_id": "C5451321", "aliases": [], "types": ["T044"], "canonical_name": "3-chloro THPH synthase activity", "definition": "Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O. [PMID:20231486, RHEA:64356]"}
{"concept_id": "C5451322", "aliases": [], "types": ["T044"], "canonical_name": "3,5 dichloro-THPH synthase activity", "definition": "Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O. [PMID:20231486, RHEA:64360]"}
{"concept_id": "C5451323", "aliases": [], "types": ["T044"], "canonical_name": "3,5-dichloro-THPH methyl transferase activity", "definition": "Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine. [PMID:20231486, RHEA:48396]"}
{"concept_id": "C5451324", "aliases": [], "types": ["T044"], "canonical_name": "D-arabinose 1-dehydrogenase (NADP+) activity", "definition": "Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH. [RHEA:21892]"}
{"concept_id": "C5451325", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to ERGIC", "definition": "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). [PMID:32272059]"}
{"concept_id": "C5451326", "aliases": [], "types": ["T043"], "canonical_name": "cytosol to ERGIC protein transport", "definition": "The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). [PMID:32272059]"}
{"concept_id": "C5451327", "aliases": ["NAD(P)+:L-arginine ADP-D-ribosyltransferase activity", "protein-arginine ADP-ribosyltransferase activity", "peptidyl-arginine ADP-ribosylation activity", "NAD(P)(+)--arginine ADP-ribosyltransferase activity", "NAD(+):L-arginine ADP-D-ribosyltransferase activity"], "types": ["T044"], "canonical_name": "NAD+-protein-arginine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide. [RHEA:19149]"}
{"concept_id": "C5451329", "aliases": [], "types": ["T044"], "canonical_name": "biliberdin reductase NAD+ activity", "definition": "Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+. [RHEA:15797]"}
{"concept_id": "C5451330", "aliases": [], "types": ["T044"], "canonical_name": "biliverdin reductase (NADP+) activity", "definition": "Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+. [RHEA:15793]"}
{"concept_id": "C5451331", "aliases": [], "types": ["T043"], "canonical_name": "regulation of UDP-N-acetylglucosamine biosynthetic process", "definition": "Any process that modulates the frequency, rate or extent of the UDP-N_acetylglucosamine biosynthetic process. [PMID:32579556]"}
{"concept_id": "C5451332", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of UDP-N-acetylglucosamine biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process. [PMID:32579556]"}
{"concept_id": "C5451333", "aliases": [], "types": ["T044"], "canonical_name": "chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: chenodeoxycholate + NAD(+) = 7-oxolithocholate + H(+) + NADH. [PMID:12917011, RHEA:42036]"}
{"concept_id": "C5451334", "aliases": [], "types": ["T044"], "canonical_name": "isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH. [PMID:12917011, RHEA:42024]"}
{"concept_id": "C5451335", "aliases": [], "types": ["T044"], "canonical_name": "ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH. [PMID:12917011, RHEA:42028]"}
{"concept_id": "C5451336", "aliases": [], "types": ["T044"], "canonical_name": "(E)-caffeate-CoA ligase activity", "definition": "Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate. [PMID:22649270, RHEA:36299]"}
{"concept_id": "C5451337", "aliases": [], "types": ["T044"], "canonical_name": "regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA", "definition": "Any process that modulates the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA. [PMID:32354837]"}
{"concept_id": "C5451338", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA. [PMID:32354837]"}
{"concept_id": "C5451339", "aliases": [], "types": ["T044"], "canonical_name": "trans-cinnamate-CoA ligase activity", "definition": "Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate. [PMID:22649270, RHEA:64788]"}
{"concept_id": "C5451340", "aliases": [], "types": ["T044"], "canonical_name": "superoxide-generating NADH oxidase activity.", "definition": "Catalysis of the reaction: NADH + 2 O2 = H(+) + NAD(+) + 2 superoxide. [RHEA:63184]"}
{"concept_id": "C5451341", "aliases": [], "types": ["T044"], "canonical_name": "NADH oxidase H202-forming activity", "definition": "Catalysis of the reaction: NADH + H+ + O2 = NAD + hydrogen peroxide (H2O2). [RHEA:11264]"}
{"concept_id": "C5451342", "aliases": [], "types": ["T044"], "canonical_name": "NADPH oxidase H202-forming activity", "definition": "Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2). [RHEA:11260]"}
{"concept_id": "C5451343", "aliases": [], "types": ["T044"], "canonical_name": "resolvin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of resolvins, di- or trihydroxy fatty acids derived from omega-3 polyunsaturated fatty acids, specifically icosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid. [PMID:24899309]"}
{"concept_id": "C5451344", "aliases": [], "types": ["T044"], "canonical_name": "D-series resolvin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of resolvin family D-series, hydroxy fatty acids derived from docosahexaenoic acid. [PMID:12391014]"}
{"concept_id": "C5451345", "aliases": [], "types": ["T044"], "canonical_name": "E-series resolvin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of resolvin family E-series, hydroxy fatty acids derived from icosapentaenoic acid. [PMID:21206090]"}
{"concept_id": "C5451346", "aliases": [], "types": ["T044"], "canonical_name": "13-series resolvin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of resolvin family 13-series, hydroxy fatty acids derived from docosapentaenoic acid. [PMID:26236990]"}
{"concept_id": "C5451347", "aliases": [], "types": ["T046"], "canonical_name": "resolution phase response", "definition": "An active host response phase of acute inflammation driven by specialized pro-resolving mediators (SPMs) and signaling pathways, enabling timely tissue regeneration and return of function. [PMID:28087575]"}
{"concept_id": "C5451348", "aliases": ["resolution of protein-DNA covalent cross-linking"], "types": ["T045"], "canonical_name": "protein-DNA covalent cross-linking repair", "definition": "The removal of covalent cross-link between DNA and a protein. [PMID:31921408]"}
{"concept_id": "C5451349", "aliases": [], "types": ["T044"], "canonical_name": "arachidonic acid 5,6-epoxygenase activity", "definition": "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid. [PMID:10491410, PMID:8631948, RHEA:49936]"}
{"concept_id": "C5451350", "aliases": [], "types": ["T044"], "canonical_name": "arachidonic acid 8,9-epoxygenase activity", "definition": "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid. [PMID:10491410, PMID:8246128, RHEA:64984]"}
{"concept_id": "C5451351", "aliases": [], "types": ["T043"], "canonical_name": "mannogen metabolic process", "definition": "The chemical reactions and pathways involving mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania. [PMID:12902334, PMID:16766650, PMID:31513773, PMID:31662278]"}
{"concept_id": "C5451352", "aliases": [], "types": ["T043"], "canonical_name": "mannogen biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania. [PMID:16766650, PMID:31513773, PMID:31662278]"}
{"concept_id": "C5451353", "aliases": [], "types": ["T043"], "canonical_name": "mannogen catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania. [PMID:12902334, PMID:31513773, PMID:31662278]"}
{"concept_id": "C5451356", "aliases": [], "types": ["T044"], "canonical_name": "progesterone 21-hydroxylase activity", "definition": "Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. [PMID:25855791, RHEA:50304]"}
{"concept_id": "C5451358", "aliases": [], "types": ["T044"], "canonical_name": "methylenetetrahydrofolate reductase NADH activity", "definition": "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD + = 5,10-methylenetetrahydrofolate + NADH + H+. [RHEA:19821]"}
{"concept_id": "C5451359", "aliases": [], "types": ["T044"], "canonical_name": "nitrite reductase NADH activity", "definition": "Catalysis of the reaction: ammonium hydroxide + 3 NAD+ + H2O = nitrite + 3 NADH + 3 H+. [RHEA:24628]"}
{"concept_id": "C5451360", "aliases": [], "types": ["T044"], "canonical_name": "methane monooxygenase NADH activity", "definition": "Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O. [RHEA:13637]"}
{"concept_id": "C5451361", "aliases": [], "types": ["T044"], "canonical_name": "methane monooxygenase NADPH activity", "definition": "Catalysis of the reaction: methane + NADPH + H+ + O2 = methanol + NADP+ + H2O. [RHEA:13641]"}
{"concept_id": "C5451362", "aliases": [], "types": ["T044"], "canonical_name": "(R)-limonene 1,2-monooxygenase NADH activity", "definition": "Catalysis of the reaction: (4R)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4R)-limonene-1,2-epoxide. [RHEA:26093]"}
{"concept_id": "C5451363", "aliases": [], "types": ["T044"], "canonical_name": "(R)-limonene 1,2-monooxygenase NADPH activity", "definition": "Catalysis of the reaction: (4R)-limonene + NADPH + H+ + O2 = NADP+ + H2O + (4R)-limonene-1,2-epoxide. [RHEA:26097]"}
{"concept_id": "C5451364", "aliases": [], "types": ["T044"], "canonical_name": "S-(hydroxymethyl)glutathione dehydrogenase NADP activity", "definition": "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+. [RHEA:19981]"}
{"concept_id": "C5451365", "aliases": [], "types": ["T044"], "canonical_name": "(S)-limonene 1,2-monooxygenase NADPH activity", "definition": "Catalysis of the reaction: (4S)-limonene + NADPH+= + H+ + O2 = NADP+ + H2O + (4S)-limonene-1,2-epoxide. [RHEA:26085]"}
{"concept_id": "C5451366", "aliases": [], "types": ["T044"], "canonical_name": "(S)-limonene 1,2-monooxygenase NADH activity", "definition": "Catalysis of the reaction: (4S)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4S)-limonene-1,2-epoxide. [RHEA:26089]"}
{"concept_id": "C5451367", "aliases": [], "types": ["T044"], "canonical_name": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP. [RHEA:56188]"}
{"concept_id": "C5451368", "aliases": [], "types": ["T044"], "canonical_name": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP. [RHEA:56192]"}
{"concept_id": "C5451369", "aliases": [], "types": ["T044"], "canonical_name": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP. [RHEA:46880]"}
{"concept_id": "C5451370", "aliases": [], "types": ["T044"], "canonical_name": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP. [RHEA:46884]"}
{"concept_id": "C5451371", "aliases": [], "types": ["T044"], "canonical_name": "L-phenylalaine oxidase activity", "definition": "Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+). [RHEA:61240]"}
{"concept_id": "C5451372", "aliases": [], "types": ["T044"], "canonical_name": "sialate 9-O-acetylesterase activity", "definition": "Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate. [RHEA:22600]"}
{"concept_id": "C5451373", "aliases": [], "types": ["T044"], "canonical_name": "sialate 4-O-acetylesterase activity", "definition": "Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate. [RHEA:25564]"}
{"concept_id": "C5451374", "aliases": [], "types": ["T045"], "canonical_name": "ds/ssDNA junction-specific dsDNA endonuclease activity", "definition": "Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction. [PMID:14528010]"}
{"concept_id": "C5451375", "aliases": [], "types": ["T044"], "canonical_name": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity", "definition": "Catalysis of the reaction: carboxymethyluridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine. [PMID:20123966, RHEA:43208]"}
{"concept_id": "C5451376", "aliases": [], "types": ["T044"], "canonical_name": "tRNA (cytidine 32-2'-O)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + cytosine32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA. [PMID:25404562]"}
{"concept_id": "C5451377", "aliases": [], "types": ["T044"], "canonical_name": "tRNA (guanosine 32-2'-O)-methyltransferase activity", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 32 in tRNA. [PMID:25404562]"}
{"concept_id": "C5451378", "aliases": [], "types": ["T044"], "canonical_name": "omega-hydroxyceramide transacylase activity", "definition": "Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine. [PMID:28248318, RHEA:55264]"}
{"concept_id": "C5451379", "aliases": [], "types": ["T044"], "canonical_name": "omega-hydroxyceramide biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of omega-hydroxyceramide/acylceramide. [PMID:28248318]"}
{"concept_id": "C5451380", "aliases": [], "types": ["T044"], "canonical_name": "glutarate dioxygenase activity", "definition": "Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2. [PMID:30498244, RHEA:13821]"}
{"concept_id": "C5451381", "aliases": [], "types": ["T044"], "canonical_name": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP", "definition": "Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]. [PMID:22568620, RHEA:65756]"}
{"concept_id": "C5451382", "aliases": [], "types": ["T044"], "canonical_name": "glyoxylate reductase activity", "definition": "Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H. [GOC:curators, PMID:3548703]"}
{"concept_id": "C5451383", "aliases": [], "types": ["T044"], "canonical_name": "U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity", "definition": "Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+. [PMID:31913360, RHEA:62672]"}
{"concept_id": "C5451384", "aliases": [], "types": ["T044"], "canonical_name": "U2 snRNA adenosine m6 methytransferase activity", "definition": "Catalysis of the reaction: a adenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-adenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+. [PMID:32637152]"}
{"concept_id": "C5451385", "aliases": [], "types": ["T045"], "canonical_name": "snRNA methylation", "definition": "The posttranscriptional addition of methyl groups to specific residues in an snRNA molecule. [PMID:21823225]"}
{"concept_id": "C5451386", "aliases": [], "types": ["T044"], "canonical_name": "octaprenyl pyrophosphate synthase activity", "definition": "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate. [PMID:3519603, PMID:8037730, RHEA:27798]"}
{"concept_id": "C5451389", "aliases": [], "types": ["T045"], "canonical_name": "tRNA surveillance", "definition": "The set of processes involved in identifying and degrading defective or aberrant tRNAs. [GOC:mah, PMID:32841241]"}
{"concept_id": "C5451390", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxybenzoate 3-monooxygenase [NADH] activity", "definition": "Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+. [RHEA:19473]"}
{"concept_id": "C5451391", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxybenzoate 3-monooxygenase [NADPH] activity", "definition": "Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+. [RHEA:19477]"}
{"concept_id": "C5451392", "aliases": [], "types": ["T044"], "canonical_name": "glycerol-1-phosphate dehydrogenase [NAD+] activity", "definition": "Catalysis of the reaction: NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH. [RHEA:21412]"}
{"concept_id": "C5451393", "aliases": [], "types": ["T044"], "canonical_name": "glycerol-1-phosphate dehydrogenase [NADP+] activity", "definition": "Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH. [RHEA:21416]"}
{"concept_id": "C5451394", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyacyl-CoA lyase activity", "definition": "Catalysis of the reaction: A 2-hydroxyacyl-CoA = formyl-CoA + a propanol. [PMID:21708296, PMID:28289220]"}
{"concept_id": "C5451395", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-3-methylhexadecanoyl-CoA lyase activity", "definition": "Catalysis of the reaction: 2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA. [RHEA:25379]"}
{"concept_id": "C5451396", "aliases": [], "types": ["T044"], "canonical_name": "protein-arginine rhamnosyltransferase activity", "definition": "Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H(+) + N(omega)-(L-rhamnosyl)-L-arginyl-[protein]. [GOC:sp, PMID:25686373, PMID:26060278, RHEA:66692]"}
{"concept_id": "C5451397", "aliases": [], "types": ["T044"], "canonical_name": "protein-arginine N-acetylglucosaminyltransferase activity", "definition": "Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP. [GOC:sp, PMID:23955153, PMID:30619781, RHEA:66632]"}
{"concept_id": "C5451398", "aliases": [], "types": ["T044"], "canonical_name": "protein-cysteine methyltransferase activity", "definition": "Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]. [GOC:sp, PMID:21481189, PMID:22158122, PMID:24235145, PMID:25412445, RHEA:66544]"}
{"concept_id": "C5451399", "aliases": [], "types": ["T044"], "canonical_name": "4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity", "definition": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]. [PMID:21944752, RHEA:20361]"}
{"concept_id": "C5451400", "aliases": [], "types": ["T044"], "canonical_name": "beta-carotene isomerase activity", "definition": "Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene. [PMID:19470589, PMID:22422982, RHEA:34455]"}
{"concept_id": "C5451401", "aliases": [], "types": ["T044"], "canonical_name": "guanosine kinase activity", "definition": "Catalysis of the reaction: ATP + guanosine = ADP + GMP. [PMID:10879466, PMID:7665468, RHEA:27710]"}
{"concept_id": "C5451402", "aliases": [], "types": ["T044"], "canonical_name": "(deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor", "definition": "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP. [PMID:20497505, RHEA:62128]"}
{"concept_id": "C5451403", "aliases": [], "types": ["T044"], "canonical_name": "(deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor", "definition": "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP. [PMID:20497505, RHEA:62132]"}
{"concept_id": "C5451404", "aliases": [], "types": ["T044"], "canonical_name": "(deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor", "definition": "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP. [PMID:20497505, RHEA:62124]"}
{"concept_id": "C5451405", "aliases": [], "types": ["T044"], "canonical_name": "protein-L-histidine N-pros-methyltransferase activity", "definition": "Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine. [PMID:33563959, RHEA:67076]"}
{"concept_id": "C5451406", "aliases": [], "types": ["T044"], "canonical_name": "fluorescent chlorophyll catabolite monooxygenase (deformylase) activity", "definition": "Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite. [PMID:23723324, RHEA:67172]"}
{"concept_id": "C5451407", "aliases": [], "types": ["T044"], "canonical_name": "primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity", "definition": "Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC. [PMID:23723324, RHEA:67176]"}
{"concept_id": "C5451408", "aliases": [], "types": ["T044"], "canonical_name": "3-deoxyglucosone dehydrogenase activity", "definition": "Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH. [PMID:17175089, RHEA:67244]"}
{"concept_id": "C5451409", "aliases": [], "types": ["T044"], "canonical_name": "deoxynucleoside triphosphate hydrolase activity", "definition": "Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate. [RHEA:46148]"}
{"concept_id": "C5451410", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxyphytanoyl-CoA lyase activity", "definition": "Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA. [PMID:10468558, RHEA:25355]"}
{"concept_id": "C5451411", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-ATP hydrolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + diphosphate. [PMID:11139615, RHEA:67392]"}
{"concept_id": "C5451412", "aliases": [], "types": ["T044"], "canonical_name": "2-hydroxy-dATP hydrolase activity", "definition": "Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate. [PMID:11139615, RHEA:31583]"}
{"concept_id": "C5451413", "aliases": ["CoA binding"], "types": ["T044"], "canonical_name": "coenzyme A binding", "definition": "Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [GOC:krc, ISBN:0198547684]"}
{"concept_id": "C5451414", "aliases": ["succinyl-coenzyme A binding"], "types": ["T044"], "canonical_name": "succinyl-CoA binding", "definition": "Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component. [GOC:krc]"}
{"concept_id": "C5451415", "aliases": ["acyl-coenzyme A binding"], "types": ["T044"], "canonical_name": "acyl-CoA binding", "definition": "Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid. [GOC:krc]"}
{"concept_id": "C5451416", "aliases": [], "types": ["T043"], "canonical_name": "protein localization to motile cilium", "definition": "A process in which a protein is transported to, or maintained in, a location within a motile cilium. [GOC:krc, PMID:27486780]"}
{"concept_id": "C5451417", "aliases": [], "types": ["T044"], "canonical_name": "recombinase activator activity", "definition": "Binds to and increases the activity of a recombinase. [GOC:mah, PMID:32414915]"}
{"concept_id": "C5451418", "aliases": ["prenylated FMNH2 synthesis", "prenylated FMNH2 biosynthetic process", "prenyl-FMNH2 anabolism", "prenyl-FMNH2 synthesis", "prenylated FMNH2 biosynthesis", "prenylated FMNH2 anabolism", "prenyl-FMNH2 formation", "prenylated FMNH2 formation", "prenyl-FMNH2 biosynthesis"], "types": ["T044"], "canonical_name": "prenyl-FMNH2 biosynthetic process", "definition": "The chemical reactions and pathways resulting in prenyl-FMNH2, an essential cofactor for the decarboxylase enzymes UbiD and Fdc1. [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754]"}
{"concept_id": "C5451419", "aliases": ["prenylated FMNH2 binding"], "types": ["T044"], "canonical_name": "prenyl-FMNH2 binding", "definition": "Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1. [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754]"}
{"concept_id": "C5451420", "aliases": ["stereocilium glycocalyx"], "types": ["T026"], "canonical_name": "stereocilium coat", "definition": "A glycocalyx on the the endolymphatic surface of a cochlear hair cell that coats the external surface of each stereocilium and maintains a small distance between adjacent stereocilia in the bundle. [GOC:krc, ISBN:9781461268918, PMID:31444330, PMID:3583936]"}
{"concept_id": "C5451421", "aliases": ["regulation of posttranslational protein targeting to membrane, translocation", "regulation of posttranslational endoplasmic reticulum membrane protein translocation"], "types": ["T043"], "canonical_name": "regulation of post-translational protein targeting to membrane, translocation", "definition": "Any process that modulates the frequency, rate or extent of posttranslational protein translocation through the ER membrane. [GOC:krc, GOC:rn, PMID:32513868]"}
{"concept_id": "C5451422", "aliases": ["negative regulation of posttranslational protein targeting to membrane, translocation", "negative regulation of posttranslational endoplasmic reticulum membrane protein translocation"], "types": ["T043"], "canonical_name": "negative regulation of post-translational protein targeting to membrane, translocation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of posttranslational protein translocation through the ER membrane. [GOC:krc, GOC:rn, PMID:32513868]"}
{"concept_id": "C5451423", "aliases": ["terminal alkyne substituted compound anabolism", "terminal alkyne substituted compound synthesis", "terminal alkyne substituted compound anabolic process", "terminal alkyne substituted compound biosynthetic process", "terminal alkyne substituted compound biosynthesis"], "types": ["T038"], "canonical_name": "terminal acetylenic compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom. [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]"}
{"concept_id": "C5451424", "aliases": [], "types": ["T026"], "canonical_name": "sperm glycocalyx", "definition": "The carbohydrate rich layer at the outermost periphery of a sperm cell. [GOC:krc]"}
{"concept_id": "C5451425", "aliases": ["endothelial glycocalyx"], "types": ["T026"], "canonical_name": "vascular endothelial glycocalyx", "definition": "The carbohydrate-rich layer lining the vascular endothelium connected to the endothelium through a variety of molecules, mainly proteoglycans and glycoproteins. These form a network in which soluble molecules, either plasma- or endothelium-derived, are incorporated. [GOC:krc, PMID:17256154]"}
{"concept_id": "C5451426", "aliases": [], "types": ["T026"], "canonical_name": "platelet glycocalyx", "definition": "The carbohydrate rich layer at the outermost periphery of a platelet. [GOC:krc, PMID:24967889]"}
{"concept_id": "C5451427", "aliases": [], "types": ["T044"], "canonical_name": "2-iminobutanoate deaminase activity", "definition": "Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+). [RHEA:39975]"}
{"concept_id": "C5451428", "aliases": [], "types": ["T044"], "canonical_name": "2-iminopropanoate deaminase activity", "definition": "Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate. [RHEA:40671]"}
{"concept_id": "C5451429", "aliases": ["terminal alkyne substituted compound metabolic process", "terminal alkyne substituted compound metabolism"], "types": ["T038"], "canonical_name": "terminal acetylenic compound metabolic process", "definition": "The chemical reactions and pathways involving a terminal acetylenic compound, involving a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom. [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]"}
{"concept_id": "C5451430", "aliases": ["terminal alkyne substituted compound catabolic process", "terminal alkyne substituted compound catabolism", "terminal alkyne substituted compound degradation", "terminal alkyne substituted compound breakdown"], "types": ["T038"], "canonical_name": "terminal acetylenic compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom. [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]"}
{"concept_id": "C5451431", "aliases": ["alkyne substituted compound metabolic process", "alkyne substituted compound metabolism"], "types": ["T038"], "canonical_name": "acetylenic compound metabolic process", "definition": "The chemical reactions and pathways involving an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C). [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]"}
{"concept_id": "C5451432", "aliases": ["alkyne substituted compound anabolism", "alkyne substituted compound biosynthetic process", "alkyne substituted compound biosynthesis", "alkyne substituted compound anabolic process", "alkyne substituted compound synthesis"], "types": ["T038"], "canonical_name": "acetylenic compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C). [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]"}
{"concept_id": "C5451433", "aliases": ["alkyne substituted compound degradation", "alkyne substituted compound catabolic process", "alkyne substituted compound breakdown", "alkyne substituted compound catabolism"], "types": ["T044"], "canonical_name": "acetylenic compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C). [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc]"}
{"concept_id": "C5451434", "aliases": ["hydrocarbon biosynthesis", "hydrocarbon anabolism", "hydrocarbon formation", "hydrocarbon synthesis"], "types": ["T044"], "canonical_name": "hydrocarbon biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a hydrocarbon, a compound consisting of carbon and hydrogen only. [GOC:krc, Wikipedia:Hydrocarbon]"}
{"concept_id": "C5451435", "aliases": ["hydrocarbon metabolism"], "types": ["T044"], "canonical_name": "hydrocarbon metabolic process", "definition": "The chemical reactions and pathways involving a hydrocarbon, a compound consisting of carbon and hydrogen only. [GOC:krc, Wikipedia:Hydrocarbon]"}
{"concept_id": "C5451436", "aliases": ["hydrocarbon degradation", "hydrocarbon catabolism", "hydrocarbon breakdown"], "types": ["T044"], "canonical_name": "hydrocarbon catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of a hydrocarbon, a compound consisting of carbon and hydrogen only. [GOC:krc, Wikipedia:Hydrocarbon]"}
{"concept_id": "C5451437", "aliases": ["alkene substituted compound metabolism", "alkene substituted compound metabolic process"], "types": ["T044"], "canonical_name": "olefinic compound metabolic process", "definition": "The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). [GOC:krc]"}
{"concept_id": "C5451438", "aliases": ["alkene substituted compound anabolic process", "alkene substituted compound synthesis", "alkene substituted compound anabolism", "alkene substituted compound biosynthesis", "alkene substituted compound biosynthetic process"], "types": ["T038"], "canonical_name": "olefinic compound biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). [GOC:krc]"}
{"concept_id": "C5451439", "aliases": ["alkene substituted compound breakdown", "alkene substituted compound catabolism", "alkene substituted compound degradation", "alkene substituted compound catabolic process"], "types": ["T040"], "canonical_name": "olefinic compound catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). [GOC:krc]"}
{"concept_id": "C5451440", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine acetylation", "definition": "The acetylation of peptidyl-threonine. [GOC:krc, PMID:16728640, PMID:22802624]"}
{"concept_id": "C5451441", "aliases": [], "types": ["T044"], "canonical_name": "peptidyl-threonine O-acetylation", "definition": "The acetylation of peptidyl-threonine to form peptidyl-O-acetyl-L-threonine. [PMID:16728640, PMID:22802624, RESID:AA0423]"}
{"concept_id": "C5451442", "aliases": ["ciliary MtQ"], "types": ["T026"], "canonical_name": "ciliary microtubule quartet", "definition": "A set of four specialized microtubules that originates from the basal bodies and wraps around the ciliary pocket membrane, likely supporting its distinct flask shape. [DOI:10.5772/66859, GOC:ach, GOC:krc, PMID:19299460, PMID:32518185]"}
{"concept_id": "C5451443", "aliases": [], "types": ["T043"], "canonical_name": "regulation of heterochromatin organization", "definition": "Any process that modulates the frequency, rate, extent or location of heterochromatin organization. [GOC:krc]"}
{"concept_id": "C5451444", "aliases": ["down-regulation of heterochromatin organization", "down regulation of heterochromatin organization", "downregulation of heterochromatin organization"], "types": ["T043"], "canonical_name": "negative regulation of heterochromatin organization", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization. [GOC:krc]"}
{"concept_id": "C5451445", "aliases": ["upregulation of heterochromatin organization", "up regulation of heterochromatin organization", "up-regulation of heterochromatin organization"], "types": ["T043"], "canonical_name": "positive regulation of heterochromatin organization", "definition": "Any process that activates or increases the frequency, rate or extent of heterochromatin organization. [GOC:krc]"}
{"concept_id": "C5451446", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chromosome attachment to the nuclear envelope", "definition": "Any process that modulates the frequency, rate, extent or location of chromosome attachment to the nuclear envelope. [GOC:krc]"}
{"concept_id": "C5451447", "aliases": ["down-regulation of chromosome attachment to the nuclear envelope", "down regulation of chromosome attachment to the nuclear envelope", "downregulation of chromosome attachment to the nuclear envelope"], "types": ["T043"], "canonical_name": "negative regulation of chromosome attachment to the nuclear envelope", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chromosome attachment to the nuclear envelope. [GOC:krc]"}
{"concept_id": "C5451448", "aliases": ["up-regulation of chromosome attachment to the nuclear envelope", "upregulation of chromosome attachment to the nuclear envelope", "up regulation of chromosome attachment to the nuclear envelope"], "types": ["T043"], "canonical_name": "positive regulation of chromosome attachment to the nuclear envelope", "definition": "Any process that activates or increases the frequency, rate or extent of the chromosome attachment to the nuclear envelope. [GOC:krc]"}
{"concept_id": "C5451449", "aliases": [], "types": ["T026"], "canonical_name": "ciliary centrin arm", "definition": "A rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules. [GOC:ach, GOC:krc, PMID:26540076, PMID:31217284]"}
{"concept_id": "C5451450", "aliases": [], "types": ["T045"], "canonical_name": "regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts", "definition": "Any process that modulates the rate, frequency, or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein. [GOC:krc, PMID:24920274]"}
{"concept_id": "C5451451", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein. [GOC:krc, PMID:24920274]"}
{"concept_id": "C5451452", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts", "definition": "Any process that activates or increases the frequency, rate or extent of degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein. [GOC:krc, PMID:24920274]"}
{"concept_id": "C5451453", "aliases": [], "types": ["T043"], "canonical_name": "ciliary centrin arm assembly", "definition": "The aggregation, arrangement and bonding together of a set of macromolecules to form a ciliary centrin arm, a rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules. [GOC:ach, GOC:krc, PMID:32675283]"}
{"concept_id": "C5451454", "aliases": ["viral coreceptor activity"], "types": ["T044"], "canonical_name": "virus coreceptor activity", "definition": "Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:ha, GOC:krc, PMID:16051304]"}
{"concept_id": "C5451455", "aliases": ["telencephelon blood circulation", "cerebrum blood circulation"], "types": ["T039"], "canonical_name": "cerebral blood circulation", "definition": "The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products. [GOC:krc, PMID:25397684]"}
{"concept_id": "C5451456", "aliases": ["regulation of cerebrum blood circulation", "regulation of telencephalon blood circulation"], "types": ["T039"], "canonical_name": "regulation of cerebral blood circulation", "definition": "Any process that modulates the frequency, rate or extent of cerebral blood circulation. [GOC:krc, PMID:25397684]"}
{"concept_id": "C5451457", "aliases": ["positive regulation of cerebrum blood circulation", "upregulation of cerebral blood circulation", "positive regulation of telencephalon blood circulation", "up-regulation of cerebral blood circulation", "up regulation of cerebral blood circulation"], "types": ["T039"], "canonical_name": "positive regulation of cerebral blood circulation", "definition": "Any process that activates or increases the frequency, rate or extent of cerebral blood circulation. [GOC:krc, PMID:25397684]"}
{"concept_id": "C5451458", "aliases": ["down-regulation of cerebral blood circulation", "negative regulation of telencephalon blood circulation", "negative regulation of cerebrum blood circulation", "downregulation of cerebral blood circulation", "down regulation of cerebral blood circulation"], "types": ["T039"], "canonical_name": "negative regulation of cerebral blood circulation", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation. [GOC:krc, PMID:25397684]"}
{"concept_id": "C5451459", "aliases": ["flagellar probasal body", "flagellar pro-basal body"], "types": ["T026"], "canonical_name": "ciliary pro-basal body", "definition": "The cilary pro-basal body is an immature, partially assembled form of a ciliary basal body found next to the basal body of a cilium. Pro-basal bodies are not capable of nucleating a cilium. As the cell progresses through the cell cycle, continuing assembly will convert the pro-basal body into a mature basal body that is capable of nucleating a cilium. [ISBN:0198547684]"}
{"concept_id": "C5451460", "aliases": [], "types": ["T026"], "canonical_name": "autolysosome membrane", "definition": "A lipid bilayer that surrounds an autolysosome, a single-membrane-bounded vesicle in which endogenous cellular material is degraded. [GOC:krc, GOC:nhn, PMID:17182262, PMID:24657946, PMID:26382870, PMID:32047650]"}
{"concept_id": "C5451461", "aliases": [], "types": ["T026"], "canonical_name": "autolysosome lumen", "definition": "The volume that is enclosed within the autolysosome single-membrane. [GOC:krc, GOC:nhn, PMID:17182262, PMID:24657946, PMID:26382870, PMID:32047650]"}
{"concept_id": "C5451462", "aliases": [], "types": ["T044"], "canonical_name": "protein serine/threonine kinase binding", "definition": "Binding to a protein serine/threonine kinase. [GOC:krc, GOC:sl, PMID:28608965]"}
{"concept_id": "C5451463", "aliases": ["Trp binding"], "types": ["T044"], "canonical_name": "tryptophan binding", "definition": "Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid. [GOC:krc]"}
{"concept_id": "C5451464", "aliases": ["tyrosine sensing activity"], "types": ["T044"], "canonical_name": "tyrosine sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine. [GOC:krc, PMID:31498992]"}
{"concept_id": "C5451465", "aliases": ["tryptophan sensing activity"], "types": ["T044"], "canonical_name": "tryptophan sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan. [GOC:krc, PMID:31498992]"}
{"concept_id": "C5451466", "aliases": [], "types": ["T044"], "canonical_name": "regulation of aspartic endopeptidase activity, intramembrane cleaving", "definition": "Any process that modulates the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity. [GOC:krc, PMID:32616437]"}
{"concept_id": "C5451467", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of aspartic endopeptidase activity, intramembrane cleaving", "definition": "Any process that decreases the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity. [GOC:krc, PMID:32616437]"}
{"concept_id": "C5451468", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of aspartic endopeptidase activity, intramembrane cleaving", "definition": "Any process that increases the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity. [GOC:krc, PMID:32616437]"}
{"concept_id": "C5451469", "aliases": ["stalled replication fork localization to nuclear periphery involved in replication fork processing"], "types": ["T043"], "canonical_name": "stalled replication fork localization to nuclear periphery", "definition": "A cellular localization process where a DNA replication fork that has stalled is signaled to relocate and anchor to the nuclear periphery for the time necessary to complete recombination-dependent replication. [GOC:krc, GOC:mah, PMID:33159083]"}
{"concept_id": "C5451470", "aliases": ["negative regulation of mitotic recombination involved in replication fork processing", "maintenance of template fidelity during replication fork processing", "negative regulation of template switch recombination involved in replication fork processing", "suppression of template switching during replication fork processing"], "types": ["T043"], "canonical_name": "negative regulation of mitotic recombination-dependent replication fork processing", "definition": "Any process that inhibits or decreases the rate of mitotic recombination-dependent replication fork processing. Suppression of recombination at replication forks is necessary to prevent template switching. [GOC:krc, GOC:mah, PMID:28586299, PMID:30667359, PMID:31149897]"}
{"concept_id": "C5451471", "aliases": ["positive regulation of recombination-dependent DNA replication"], "types": ["T045"], "canonical_name": "positive regulation of mitotic recombination-dependent replication fork processing", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic recombination-dependent replication fork processing. Regulation of mitotic recombination prevents recombination between inappropriate homologous sequences. Proteins involved in homologous recombination are required for replication restart. [GOC:krc, GOC:mah, PMID:23093942, PMID:28586299, PMID:31149897]"}
{"concept_id": "C5451472", "aliases": [], "types": ["T044"], "canonical_name": "peptide serotonyltransferase activity", "definition": "Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+). [GOC:sp, PMID:14697203]"}
{"concept_id": "C5451473", "aliases": [], "types": ["T044"], "canonical_name": "histone serotonyltransferase activity", "definition": "Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+). [GOC:sp, PMID:30867594]"}
{"concept_id": "C5451474", "aliases": [], "types": ["T044"], "canonical_name": "peptide dopaminyltransferase activity", "definition": "Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+). [GOC:sp, PMID:22858378, PMID:32273471]"}
{"concept_id": "C5451475", "aliases": [], "types": ["T044"], "canonical_name": "histone dopaminyltransferase activity", "definition": "Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+). [GOC:sp, PMID:32273471]"}
{"concept_id": "C5451476", "aliases": [], "types": ["T044"], "canonical_name": "peptide noradrenalinyltransferase activity", "definition": "Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+). [GOC:sp, PMID:22858378]"}
{"concept_id": "C5451477", "aliases": [], "types": ["T044"], "canonical_name": "peptide histaminyltransferase activity", "definition": "Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein]. [GOC:sp, PMID:23022564, PMID:23797785]"}
{"concept_id": "C5451478", "aliases": [], "types": ["T044"], "canonical_name": "peptide lactyltransferase activity", "definition": "Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]. [GOC:sp, PMID:31645732, RHEA:61996]"}
{"concept_id": "C5451479", "aliases": [], "types": ["T044"], "canonical_name": "histone lactyltransferase activity", "definition": "Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[histone]. [GOC:sp, PMID:31645732]"}
{"concept_id": "C5451480", "aliases": [], "types": ["T040"], "canonical_name": "background adaptation", "definition": "Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity. [GOC:cvs, GOC:krc, PMID:10493760, PMID:29239123, PMID:32898924]"}
{"concept_id": "C5451481", "aliases": [], "types": ["T040"], "canonical_name": "visually-mediated background adaptation", "definition": "Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by melanopsin-expressing eye cells. [GOC:cvs, GOC:krc, PMID:29239123, PMID:32898924]"}
{"concept_id": "C5451482", "aliases": [], "types": ["T040"], "canonical_name": "integument-mediated background adaptation", "definition": "Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by light sensitive cells in the integument. [GOC:cvs, GOC:krc, PMID:29239123, PMID:32898924]"}
{"concept_id": "C5451483", "aliases": [], "types": ["T038"], "canonical_name": "regulation of pigmentation", "definition": "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. [GOC:krc]"}
{"concept_id": "C5451484", "aliases": ["cellular response to actin cytoskeleton stress"], "types": ["T043"], "canonical_name": "cellular response to actin cytoskeletal stress", "definition": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of perturbations or damage to the actin cytoskeleton. [GOC:krc, GOC:vw, PMID:32915139]"}
{"concept_id": "C5451485", "aliases": [], "types": ["T026"], "canonical_name": "Hechtian strand", "definition": "An extended membranous thread which firmly connects the plasma membrane to the cell wall during plasmolysis such that the plasma membrane does not separate from the cell wall completely. [GOC:krc, PMID:32397402]"}
{"concept_id": "C5451486", "aliases": ["axonemal outer doublet biogenesis", "axonemal outer doublet morphogenesis", "axonemal outer doublet formation", "axoneme outer doublet assembly"], "types": ["T043"], "canonical_name": "axonemal outer doublet assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an axonemal outer doublet, a part of an axoneme consisting of a doublet microtubule. [GOC:ach, GOC:krc, PMID:16278296]"}
{"concept_id": "C5451487", "aliases": ["flagellum attachment to cell body", "cilial attachment to cell body", "ciliary attachment to cell body", "flagellar attachment to cell body"], "types": ["T043"], "canonical_name": "cilium attachment to cell body", "definition": "A process that is carried out at the cellular level which results in the lateral attachment of the cilium to the cell body via the flagellar attachment zone in some trypanosomatid species. [GOC:ach, GOC:krc, PMID:11877446, PMID:18820079, PMID:22623724, PMID:26272611]"}
{"concept_id": "C5451488", "aliases": [], "types": ["T040"], "canonical_name": "amastigogenesis", "definition": "The morphological, biochemical and genetic changes that induce the differentiation of metacyclic parasites into amastigotes in some of the Trypanosomatidae species such as Leishmania parasites and Trypanosoma cruzi. This process occurs inside the cells of the mammalian hosts, particularly in macrophages and other phagocytic cells for Leishmania parasites. [DOI:10.5772/intechopen.84639, GOC:ach, GOC:krc, PMID:12377273, PMID:13129524, PMID:26752404]"}
{"concept_id": "C5451489", "aliases": [], "types": ["T043"], "canonical_name": "ciliary pro-basal body maturation", "definition": "A process that is carried out at the cellular level which results in the conversion of an immature and partially assembled ciliary pro-basal body into a mature basal body that is capable of nucleating a cilium. [GOC:ach, GOC:krc, PMID:26862392]"}
{"concept_id": "C5451490", "aliases": [], "types": ["T043"], "canonical_name": "regulation of oocyte karyosome formation", "definition": "Any process that modulates the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome. [GOC:ha, GOC:krc, PMID:33382409]"}
{"concept_id": "C5451491", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of oocyte karyosome formation", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome. [GOC:ha, GOC:krc, PMID:33382409]"}
{"concept_id": "C5451492", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of oocyte karyosome formation", "definition": "Any process that activates or increases the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome. [GOC:ha, GOC:krc, PMID:33382409]"}
{"concept_id": "C5451493", "aliases": [], "types": ["T043"], "canonical_name": "sperm flagellum assembly", "definition": "The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium). [GOC:krc, PMID:32791035]"}
{"concept_id": "C5451494", "aliases": [], "types": ["T039"], "canonical_name": "sperm mitochondrial sheath assembly", "definition": "The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. [GOC:krc, PMID:32791035]"}
{"concept_id": "C5451495", "aliases": ["negative regulation by symbiont of host cytokine production"], "types": ["T040"], "canonical_name": "suppression by symbiont of host cytokine production", "definition": "Any process in which a symbiont stops, prevents, or reduces the rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:23083102]"}
{"concept_id": "C5451496", "aliases": [], "types": ["T044"], "canonical_name": "transcription regulator inhibitor activity", "definition": "A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification. [PMID:10652346]"}
{"concept_id": "C5451498", "aliases": [], "types": ["T045"], "canonical_name": "pericentric heterochromatin organization", "definition": "The organization of chromatin into heterochromatin at the pericentric region of a chromosome. [PMID:26744419]"}
{"concept_id": "C5451499", "aliases": ["chromatin receptor", "protein-chromatin adaptor activity", "chromatin adaptor", "chromatin adaptor activity"], "types": ["T044"], "canonical_name": "chromatin-protein adaptor", "definition": "The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex. [PMID:32277274]"}
{"concept_id": "C5451500", "aliases": [], "types": ["T043"], "canonical_name": "silent mating-type cassette heterochromatin organization", "definition": "The organization of chromatin into heterochromatin at a silent mating-type cassette locus. [PMID:26744419]"}
{"concept_id": "C5451501", "aliases": [], "types": ["T044"], "canonical_name": "iron-sulfur cluster export from the mitochondrion", "definition": "The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane. [PMID:31040179]"}
{"concept_id": "C5451502", "aliases": ["EIF2AK1-mediated signaling"], "types": ["T044"], "canonical_name": "HRI-mediated signaling", "definition": "A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. [PMID:27629041]"}
{"concept_id": "C5451503", "aliases": ["EIF2AK4-mediated signaling"], "types": ["T044"], "canonical_name": "GCN2-mediated signaling", "definition": "A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation. [PMID:27629041]"}
{"concept_id": "C5451504", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of transepithelial migration of symbiont in host", "definition": "Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host. [PMID:29113016]"}
{"concept_id": "C5451505", "aliases": [], "types": ["T026"], "canonical_name": "cell cortex of non-growing cell tip", "definition": "The region directly beneath the plasma membrane at the cell tip at which no growth takes place. [PMID:17895368]"}
{"concept_id": "C5451506", "aliases": ["nuclear envelope-telomere anchor activity", "telomere-nuclear envelope anchoring activity"], "types": ["T044"], "canonical_name": "telomere-nuclear envelope anchor activity", "definition": "The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location. [PMID:31635174]"}
{"concept_id": "C5451507", "aliases": ["mitochondrion-ER membrane adaptor activity", "mitochondrion-ER membrane tether activity", "ER-mitochondrion membrane adaptor activity", "ER-mitochondrion membrane tether activity", "endoplasmic reticulum-mitochondrion membrane adaptor activity", "endoplasmic reticulum-mitochondrion membrane tether activity", "mitochondrion-endoplasmic reticulum membrane adaptor activity"], "types": ["T044"], "canonical_name": "mitochondrion-endoplasmic reticulum membrane tether activity", "definition": "The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion. [PMID:19556461, PMID:27875684]"}
{"concept_id": "C5451508", "aliases": [], "types": ["T044"], "canonical_name": "spindle pole body anchor activity", "definition": "The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way. [PMID:19942852]"}
{"concept_id": "C5451509", "aliases": [], "types": ["T044"], "canonical_name": "ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase", "definition": "A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide. [PMID:22209968, PMID:24828577]"}
{"concept_id": "C5451510", "aliases": ["establishment of spindle pole body localization to nuclear envelope", "establishment of spindle pole body localisation in nuclear envelope", "establishment of spindle pole body localization in nuclear envelope"], "types": ["T043"], "canonical_name": "mitotic spindle pole body insertion into the nuclear envelope", "definition": "A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane. [PMID:19487457, PMID:24529240]"}
{"concept_id": "C5451511", "aliases": ["ATPase-coupled Fe-S cluster transmembrane transporter activity"], "types": ["T044"], "canonical_name": "ABC-type iron-sulfur cluster transporter activity", "definition": "Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out). [PMID:31040179]"}
{"concept_id": "C5451512", "aliases": [], "types": ["T044"], "canonical_name": "iron sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron. [PMID:11956219, PMID:25806539]"}
{"concept_id": "C5451513", "aliases": [], "types": ["T044"], "canonical_name": "kinetochore adaptor activity", "definition": "The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way. [PMID:22521786]"}
{"concept_id": "C5451514", "aliases": [], "types": ["T043"], "canonical_name": "5-aminolevulinic acid import across plasma membrane", "definition": "The directed movement of 5-aminolevulinic acid from outside of a cell, across the plasma membrane and into the cytosol. [PMID:31989647]"}
{"concept_id": "C5451515", "aliases": [], "types": ["T044"], "canonical_name": "5-aminolevulinic acid transmembrane transporter activity", "definition": "Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other. [PMID:31989647, RHEA:64816]"}
{"concept_id": "C5451516", "aliases": [], "types": ["T044"], "canonical_name": "zinc ion sequestering activity", "definition": "Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:12050156]"}
{"concept_id": "C5451517", "aliases": [], "types": ["T044"], "canonical_name": "metal ion sequestering activity", "definition": "Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:12050156]"}
{"concept_id": "C5451518", "aliases": [], "types": ["T044"], "canonical_name": "heme receptor activity", "definition": "Binding specifically to heme to deliver it to a transport vesicle. [PMID:28193844, PMID:32185489]"}
{"concept_id": "C5451519", "aliases": [], "types": ["T044"], "canonical_name": "molecular template activity", "definition": "The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence. [GOC:pg]"}
{"concept_id": "C5451520", "aliases": ["microtubule nucleation template activity"], "types": ["T044"], "canonical_name": "microtubule nucleator activity", "definition": "The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly. [PMID:20631709, PMID:21993292]"}
{"concept_id": "C5451521", "aliases": ["metal-dependent ubiquitinyl-like hydrolase activity", "metal-dependent ubiquitin-like hydrolase activity"], "types": ["T044"], "canonical_name": "metal-dependent deubiquitinase activity", "definition": "An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [PMID:19489724]"}
{"concept_id": "C5451522", "aliases": [], "types": ["T044"], "canonical_name": "very long-chain fatty acid beta-oxidation", "definition": "A fatty acid beta-oxidation pathway acting on fatty acid which has a chain length greater than C22 in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:ha, PMID:17028011, PMID:32169171]"}
{"concept_id": "C5451523", "aliases": [], "types": ["T026"], "canonical_name": "migrasome", "definition": "A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration. [PMID:25342562, PMID:31371827]"}
{"concept_id": "C5451524", "aliases": [], "types": ["T043"], "canonical_name": "migracytosis", "definition": "A cell migration-dependent mechanism for releasing cellular contents. [PMID:25342562]"}
{"concept_id": "C5451525", "aliases": [], "types": ["T044"], "canonical_name": "gamma-tubulin complex binding", "definition": "Binding to a gamma-tubulin complex. [PMID:30174135]"}
{"concept_id": "C5451526", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of mitotic spindle assembly checkpoint signaling", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling. [PMID:28017606]"}
{"concept_id": "C5451527", "aliases": ["regulation of ER-phagy", "regulation of autophagy of the endoplasmic reticulum", "regulation of autophagy of the ER", "regulation of ER autophagy", "regulation of endoplasmic reticulum autophagy"], "types": ["T043"], "canonical_name": "regulation of reticulophagy", "definition": "Any process that modulates the frequency, rate or extent of reticulophagy. [PMID:32735772]"}
{"concept_id": "C5451528", "aliases": ["positive regulation of ER-phagy", "positive regulation of endoplasmic reticulum autophagy", "positive regulation of ER autophagy", "positive regulation of autophagy of the ER", "positive regulation of autophagy of the endoplasmic reticulum"], "types": ["T043"], "canonical_name": "positive regulation of reticulophagy", "definition": "Any process that increases the frequency, rate or extent of reticulophagy. [PMID:32735772]"}
{"concept_id": "C5451529", "aliases": [], "types": ["T040"], "canonical_name": "effector-mediated suppression of host salicylic acid-mediated innate immune signalling", "definition": "A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signalling. [PMID:25438793, PMID:30651637]"}
{"concept_id": "C5451530", "aliases": ["lipid droplet autophagy"], "types": ["T043"], "canonical_name": "microlipophagy", "definition": "Microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion, such as during the transition to stationary phase or in response to nutrient limitation. Microlipophagy is mediated by the formation of sterol-enriched vacuolar microdomains at sites of engulfment. Initiation of microautophagy is defined as the point where liquid-ordered microdomains are formed at sites of engulfment, that requires S. cerevisiae Atg32p and Atg21p, as well as Niemann-Pick type C (NPC) sterol transporter proteins, Ncr1p and Npc2p. This is followed by redistribution of Atg14p from ER exit sites onto liquid-ordered vacuole membrane domains through interaction with stabilized AMP-activated protein kinase (AMPK), and together with Atg6p facilities docking and internalization of lipid droplets (LDs) at sites of invagination. [PMID:25070953, PMID:28394250, PMID:28838958, PMID:29293450, PMID:29601311]"}
{"concept_id": "C5451531", "aliases": [], "types": ["T043"], "canonical_name": "regulation of microlipophagy", "definition": "Any process that modulates the frequency, rate or extent of microlipophagy, the microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion. [PMID:28394250, PMID:29601311]"}
{"concept_id": "C5451532", "aliases": ["autophagosome-ER anchor", "ER- autophagosome anchor", "autophagosome-endoplasmic reticulum anchor"], "types": ["T044"], "canonical_name": "endoplasmic reticulum-autophagosome adaptor activity", "definition": "The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy. [PMID:32735772]"}
{"concept_id": "C5451533", "aliases": [], "types": ["T043"], "canonical_name": "granzyme-mediated programmed cell death signaling pathway", "definition": "The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells. [PMID:32299851]"}
{"concept_id": "C5451534", "aliases": [], "types": ["T040"], "canonical_name": "epithelium-like organization", "definition": "The organization of a polarized cell layer during morphogenesis in protozoa; an example is found during culmination in D. discoideum, involving alpha and beta catenins. [PMID:21393547, PMID:22902739]"}
{"concept_id": "C5451535", "aliases": [], "types": ["T026"], "canonical_name": "mitotic nuclear bridge", "definition": "A narrow constricted region of the nucleus that forms around the anaphase spindle during closed mitosis, and connects the main portions of the newly forming daughter nuclei. [PMID:32848252]"}
{"concept_id": "C5451536", "aliases": [], "types": ["T026"], "canonical_name": "mitotic nuclear bridge stalk", "definition": "Either of the regions of a mitotic nuclear bridge proximal to the main portion of each daughter nucleus. The nuclear envelope in the stalk regions is depleted of nuclear pore complexes. [PMID:32848252]"}
{"concept_id": "C5451537", "aliases": [], "types": ["T026"], "canonical_name": "mitotic nuclear bridge midzone", "definition": "The central region of a mitotic nuclear bridge, distal to the main portions of the daughter nuclei. [PMID:32848252]"}
{"concept_id": "C5451538", "aliases": [], "types": ["T043"], "canonical_name": "mitotic nuclear bridge organization", "definition": "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the mitotic nuclear bridge during closed mitosis. [PMID:32848252]"}
{"concept_id": "C5451539", "aliases": ["nuclear pore complex disassembly during mitosis"], "types": ["T043"], "canonical_name": "mitotic nuclear pore complex disassembly", "definition": "The mitotic cell cycle process in which the controlled breakdown of the nuclear pores occurs during open or closed mitosis. [PMID:32848252]"}
{"concept_id": "C5451540", "aliases": [], "types": ["T044"], "canonical_name": "protein-RNA adaptor activity", "definition": "The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way. [PMID:24470144]"}
{"concept_id": "C5451541", "aliases": [], "types": ["T043"], "canonical_name": "fusogenic activity", "definition": "The activity of joining two lipid bilayers to form a single membrane. [PMID:10332732, PMID:11493675, PMID:12600315, PMID:32100701, PMID:32641474]"}
{"concept_id": "C5451542", "aliases": ["membrane fusion GTPase activity"], "types": ["T044"], "canonical_name": "GTPase-dependent fusogenic activity", "definition": "A GTPase activity that mediates the joining two lipid bilayers to form a single membrane. [PMID:29663589]"}
{"concept_id": "C5451543", "aliases": ["antipodal zone"], "types": ["T026"], "canonical_name": "antipodal site", "definition": "The pole of the kinetoplast associated with kinetoplast DNA replication. The antipodal sites flank the kinetoplast DNA disk and are positioned approximately 180 degrees apart. In Trypanosoma brucei and Crithidia fasciculata, minicircles are attached at antipodal sites and they contain enzymes that catalyse some of the later reactions in minicircle replication. [PMID:12455998, PMID:17462016, PMID:8045928]"}
{"concept_id": "C5451544", "aliases": [], "types": ["T043"], "canonical_name": "double membrane vesicle viral factory assembly", "definition": "A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle. [PMID:32555292]"}
{"concept_id": "C5451545", "aliases": [], "types": ["T045"], "canonical_name": "reciprocal homologous recombination", "definition": "A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules. [PMID:17846636]"}
{"concept_id": "C5451546", "aliases": ["bilobe structure biogenesis", "kinetoplastid flagellar hook complex assembly", "bilobe structure formation"], "types": ["T043"], "canonical_name": "bilobe structure assembly", "definition": "The assembly and organization of a bilobe structure, a cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone). [PMID:18443217, PMID:32675283]"}
{"concept_id": "C5451547", "aliases": [], "types": ["T044"], "canonical_name": "CMG complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form the CMG complex, a protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. The process begins when additional proteins (e.g. Cdc45 and Sld3) join the loaded, inactive double MCM hexamer at replication origins, and ends when Mcm10 triggers the separation of the Mcm2-7 double hexamers, forming two active CMG complexes. [PMID:22718908, PMID:28501329]"}
{"concept_id": "C5451548", "aliases": ["MCM double hexamer formation at replication origin", "MCM complex loading at replication origin"], "types": ["T043"], "canonical_name": "MCM complex loading", "definition": "The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly. [PMID:23603117, PMID:28191893, PMID:28191894, PMID:28501329]"}
{"concept_id": "C5451549", "aliases": [], "types": ["T043"], "canonical_name": "regulation of osmosensory signaling MAPK cascade", "definition": "Any process that modulates the frequency, rate or extent of osmosensory signaling MAPK cascade. [PMID:31911490]"}
{"concept_id": "C5451550", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of osmosensory signaling MAPK cascade", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling MAPK cascade. [PMID:31911490]"}
{"concept_id": "C5451551", "aliases": ["suppression of host RNAi-mediated antiviral immunity", "suppression of host RNAi-mediated gene silencing"], "types": ["T040"], "canonical_name": "suppression of host RNAi-mediated antiviral immune response", "definition": "Any process in which a symbiont stops, prevents, or reduces the rate or extent of the host's RNAi-mediated antiviral immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:17693253]"}
{"concept_id": "C5451552", "aliases": [], "types": ["T045"], "canonical_name": "nuclear receptor corepressor activity", "definition": "A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [PMID:7566114, PMID:7566126, PMID:9238851]"}
{"concept_id": "C5451553", "aliases": [], "types": ["T044"], "canonical_name": "transcription regulator activator activity", "definition": "A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification. [PMID:9597751]"}
{"concept_id": "C5451554", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of conjugation with zygote", "definition": "A process that prevents a zygote from fusing an additional cell. [PMID:30089908]"}
{"concept_id": "C5451555", "aliases": [], "types": ["T038"], "canonical_name": "regulation of melanotic encapsulation of foreign target", "definition": "Any process that modulates the frequency, rate or extent of melanotic encapsulation of foreign target. [PMID:15749104, PMID:18457993]"}
{"concept_id": "C5451556", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation melanotic encapsulation of foreign target", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of melanotic encapsulation of foreign target. [PMID:15749104, PMID:18457993]"}
{"concept_id": "C5451557", "aliases": ["Piwi-associated RNA transcription", "PIWI-interacting RNA transcription"], "types": ["T045"], "canonical_name": "piRNA transcription", "definition": "The cellular synthesis of Piwi-interacting RNA piRNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. [PMID:28847004]"}
{"concept_id": "C5451558", "aliases": [], "types": ["T045"], "canonical_name": "regulation of piRNA transcription", "definition": "Any process that modulates the frequency, rate or extent of the synthesis of a piRNA. [PMID:28847004]"}
{"concept_id": "C5451559", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of piRNA transcription", "definition": "Any process that increases the frequency, rate or extent of the synthesis of piRNA. [PMID:28847004]"}
{"concept_id": "C5451560", "aliases": ["cellular bud neck septin hourglass organization"], "types": ["T043"], "canonical_name": "septin collar organization", "definition": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising the septin collar. [PMID:21736496, PMID:32386534]"}
{"concept_id": "C5451561", "aliases": [], "types": ["T044"], "canonical_name": "protein disaggregase activity"}
{"concept_id": "C5451562", "aliases": [], "types": ["T040"], "canonical_name": "defense response to symbiont", "definition": "Reactions triggered in response to the presence of a symbiont that act to protect the cell or organism from damage caused by that symbiont. [GOC:pg]"}
{"concept_id": "C5451563", "aliases": [], "types": ["T040"], "canonical_name": "acquisition of seed longevity", "definition": "The acquisition of seed longevity is the ordered series of events during seed development, that prevent embryo deterioration and ROS damage and thus contribute to seed viability over time or in response to adverse environmental conditions. These events include protective (e.g. production of glassy cytoplasm ) and repair (e.g. oxidative stress responses) processes. [PMID:26637538]"}
{"concept_id": "C5451564", "aliases": ["envenomation resulting in erythrocytes agglutination in other organism", "envenomation resulting in blood agglutination in other organism", "envenomation resulting in red blood cells agglutination in other organism"], "types": ["T039"], "canonical_name": "envenomation resulting in blood agglutination in another organism", "definition": "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with specific proteins binding to cell-surface carbohydrates and causing calcium-dependent agglutination of blood cells in the bitten organism. [PMID:10484740]"}
{"concept_id": "C5451565", "aliases": [], "types": ["T026"], "canonical_name": "spore inner membrane", "definition": "The membrane surrounding the spore core (endospore core) that separates it from its external environment. [PMID:23202530]"}
{"concept_id": "C5451566", "aliases": ["phosphatidylinositol-4,5-bisphosphate sensing activity"], "types": ["T044"], "canonical_name": "phosphatidylinositol-4,5-bisphosphate sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate. [PMID:33172987]"}
{"concept_id": "C5451568", "aliases": [], "types": ["T044"], "canonical_name": "xylosyl alpha-1,3-xylosyltransferase activity", "definition": "Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains. [PMID:22117070, PMID:8982869, RHEA:22820]"}
{"concept_id": "C5451569", "aliases": [], "types": ["T044"], "canonical_name": "EGF-domain serine glucosyltransferase activity", "definition": "Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine. [RHEA:58116]"}
{"concept_id": "C5451570", "aliases": [], "types": ["T044"], "canonical_name": "EGF-domain serine xylosyltransferase activity", "definition": "Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine. [RHEA:62016]"}
{"concept_id": "C5451571", "aliases": [], "types": ["T044"], "canonical_name": "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity", "definition": "Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. [EC:2.4.2.42, PMID:30127001, RHEA:56064]"}
{"concept_id": "C5451572", "aliases": [], "types": ["T044"], "canonical_name": "epigenetic reader"}
{"concept_id": "C5451573", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane protein dislocase activity", "definition": "The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. The reaction is driven by ATP hydrolysis. [PMID:24821790, PMID:28712723, PMID:32973005]"}
{"concept_id": "C5451574", "aliases": [], "types": ["T043"], "canonical_name": "extraction of mislocalized protein from membrane", "definition": "The removal of a mislocalized protein from a cellular membrane. [PMID:24821790, PMID:28712723, PMID:32973005]"}
{"concept_id": "C5451575", "aliases": [], "types": ["T043"], "canonical_name": "extraction of mislocalized protein from ER membrane", "definition": "The removal of a mislocalized protein from the endoplasmic reticulum (ER) membrane. [PMID:32973005]"}
{"concept_id": "C5451576", "aliases": ["extraction of mislocalized protein from outer mitochondrion membrane"], "types": ["T043"], "canonical_name": "extraction of mislocalized protein from mitochondrial outer membrane", "definition": "The removal of a mislocalized protein from the mitochondrial outer membrane. [PMID:32973005]"}
{"concept_id": "C5451577", "aliases": [], "types": ["T043"], "canonical_name": "vacuole fission", "definition": "The division of a vacuole within a cell to form two or more separate vacuoles. [PMID:19643199]"}
{"concept_id": "C5451578", "aliases": ["histone H3 containing nucleosome"], "types": ["T026"], "canonical_name": "histone H3-containing nucleosome", "definition": "A complex comprised of DNA wound around a multisubunit core and associated proteins containing the histone H3, which forms the primary packing unit of DNA into higher order structures. [PMID:33155135]"}
{"concept_id": "C5451579", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane monodehydroascorbate reductase activity", "definition": "Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction. [PMID:1623014, RHEA:66524]"}
{"concept_id": "C5451580", "aliases": ["mitophagy receptor"], "types": ["T044"], "canonical_name": "mitochondrion autophagosome adaptor activity", "definition": "The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy. [PMID:33138913]"}
{"concept_id": "C5451581", "aliases": [], "types": ["T044"], "canonical_name": "P-type monovalent copper transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) -> ADP + phosphate + Cu+(out). [RHEA:25792]"}
{"concept_id": "C5451582", "aliases": ["extracellular cAMP signaling pathway"], "types": ["T043"], "canonical_name": "adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway", "definition": "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by extracellular cAMP binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. [PMID:9578623]"}
{"concept_id": "C5451583", "aliases": ["chromatin extrusion activity"], "types": ["T045"], "canonical_name": "chromatin extrusion motor activity", "definition": "A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis. [PMID:23074191, PMID:26499245, PMID:27210764]"}
{"concept_id": "C5451584", "aliases": ["enhancer-promoter loop anchoring activity"], "types": ["T045"], "canonical_name": "promoter-enhancer loop anchoring activity", "definition": "Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop. [PMID:32213323]"}
{"concept_id": "C5451585", "aliases": ["terminator-promoter loop anchoring activity"], "types": ["T045"], "canonical_name": "promoter-terminator loop anchoring activity", "definition": "Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop. [PMID:19933151]"}
{"concept_id": "C5451586", "aliases": ["chromosomal loop binding", "DNA loop binding"], "types": ["T045"], "canonical_name": "chromatin loop anchoring activity", "definition": "Bridging together two DNA loop anchors together, maintaining a chromatin loop. [PMID:32213323]"}
{"concept_id": "C5451587", "aliases": ["effector-mediated suppression of host defenses by symbiont"], "types": ["T040"], "canonical_name": "effector-mediated suppression of host defenses", "definition": "A process mediated by a molecule secreted by a symbiont that results in the supression of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:28082413]"}
{"concept_id": "C5451588", "aliases": [], "types": ["T043"], "canonical_name": "nuclear envelope budding", "definition": "The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm. [PMID:27236823, PMID:32503943]"}
{"concept_id": "C5451589", "aliases": [], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-R8 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to arginine at position 8 of histone H3. [PMID:20708585, PMID:31533925]"}
{"concept_id": "C5451590", "aliases": ["host cell apoplast"], "types": ["T026"], "canonical_name": "host apoplast", "definition": "The apoplast region surrounding a host plant cell. Plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:28082413]"}
{"concept_id": "C5451591", "aliases": [], "types": ["T044"], "canonical_name": "xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity", "definition": "Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase. [PMID:28082413]"}
{"concept_id": "C5451592", "aliases": [], "types": ["T044"], "canonical_name": "lipoprotein carrier activity", "definition": "Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein. [PMID:7628437]"}
{"concept_id": "C5451593", "aliases": [], "types": ["T026"], "canonical_name": "mitotic nuclear bridge midzone membrane domain", "definition": "A nuclear membrane part at the midzone of the mitotic nuclear bridge. The midzone forms a bulge that is enriched in nuclear pores that lack baskets. [PMID:25963819, PMID:32502403]"}
{"concept_id": "C5451594", "aliases": [], "types": ["T044"], "canonical_name": "mycofactocin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of the coenzyme mycofactocin, a variably glycosylated small molecule electron pair carrier derived from the C-terminal valine-tyrosine dipeptide of the ribosomally translated precursor peptide MftA. [PMID:21223593, PMID:27312813, PMID:30183269, PMID:30778644, PMID:31381312, PMID:33014324]"}
{"concept_id": "C5451595", "aliases": [], "types": ["T044"], "canonical_name": "proton motive force-driven motor activity", "definition": "A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella. [PMID:18216858]"}
{"concept_id": "C5451596", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type endopeptidase activator activity", "definition": "Binds to and increases the activity of a cysteine-type endopeptidase. [PMID:32558991]"}
{"concept_id": "C5451597", "aliases": ["phycocyanobilin biosynthesis"], "types": ["T044"], "canonical_name": "phycocyanobilin biosynthetic process", "definition": "The chemical reactions or pathway resulting in the formation of phycocyanobilin, which involves the oxidative cleavage of heme by a heme oxygenase (HO) to form biliverdin IX alpha. Biliverdin IX alpha is subsequently converted to phycocyanobilin by a ferredoxin-dependent oxidoreductase (PCYA). [PMID:23345435]"}
{"concept_id": "C5451598", "aliases": [], "types": ["T044"], "canonical_name": "RNA sequestering activity", "definition": "Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:29084823]"}
{"concept_id": "C5451599", "aliases": ["DNA damage sensing activity"], "types": ["T044"], "canonical_name": "DNA damage sensor activity", "definition": "A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signalling response. [PMID:31995034]"}
{"concept_id": "C5451600", "aliases": [], "types": ["T044"], "canonical_name": "P-type manganese transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate. [PMID:11134055, PMID:15590060, PMID:15831496, PMID:21187401, RHEA:66820]"}
{"concept_id": "C5451601", "aliases": ["DHN-melanin biosynthesis"], "types": ["T044"], "canonical_name": "1,8-dihydroxynaphthalene-melanin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of dihydroxy naphthalene (DHN)-melanin. [PMID:12788746, PMID:23998343]"}
{"concept_id": "C5451602", "aliases": [], "types": ["T045"], "canonical_name": "transvection", "definition": "An epigenetic regulation of transcription by physical interaction between a cis-acting element (enhancer, silencer) of one allele on one chromosome and the promoter of the corresponding allele on the homologous chromosome. Transvection can lead to either gene activation or repression. [PMID:24236213, PMID:33479152]"}
{"concept_id": "C5451603", "aliases": ["NADH:Fe(3+) oxidoreductase activity", "NADH:Fe3+ oxidoreductase activity"], "types": ["T044"], "canonical_name": "ferric-chelate reductase (NADH) activity", "definition": "Catalysis of the reaction: 2 Fe3+-siderophore + NAD(+) + H(+) -> 2 Fe2+-siderophore + NADH. [RHEA:15061]"}
{"concept_id": "C5451604", "aliases": [], "types": ["T044"], "canonical_name": "DNA strand exchange activator activity", "definition": "Binds to and increases a DNA strand exchange activity. [PMID:33493431]"}
{"concept_id": "C5451605", "aliases": [], "types": ["T044"], "canonical_name": "DNA strand exchange inhibitor activity", "definition": "Binds to and stops, prevents or reduces a DNA strand exchange activity. [PMID:33493431]"}
{"concept_id": "C5451606", "aliases": ["type I fimbriae", "type I pili", "type 1 pilus"], "types": ["T026"], "canonical_name": "type I pilus", "definition": "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by their D-mannose-sensitive agglutinatination of erythrocytes. In E. coli, type I pili consist of a short tip fibrillum made up of the adhesin protein (FimH) and two minor subunits (FimG and FimF) that is joined to the pilus rod, a homopolymer of ~1000 FimA subunits. [PMID:28496159, PMID:29345620]"}
{"concept_id": "C5451607", "aliases": [], "types": ["T043"], "canonical_name": "EGAD pathway", "definition": "The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation. [PMID:31368600]"}
{"concept_id": "C5451608", "aliases": ["methionine enkephalin receptor activity"], "types": ["T044"], "canonical_name": "opioid growth factor receptor activity", "definition": "Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes. [PMID:11890982]"}
{"concept_id": "C5451609", "aliases": [], "types": ["T043"], "canonical_name": "opioid growth factor receptor signaling pathway", "definition": "The series of molecular signals generated as a consequence of an opioid growth factor receptor binding to its physiological ligand, opioid growth factor (OGF, met-enkephalin). The OGF-OGFr complex leads to the increase in the synthesis of the selective cyclin-dependent kinase (CDK) inhibitor proteins, p12 (POLD4) and p16 (CDKN2A). [PMID:19675283, PMID:19923357]"}
{"concept_id": "C5451610", "aliases": [], "types": ["T043"], "canonical_name": "ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "definition": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. [PMID:29775578, PMID:29779948]"}
{"concept_id": "C5451611", "aliases": [], "types": ["T044"], "canonical_name": "outward rectifier potassium channel inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel. [PMID:28108814]"}
{"concept_id": "C5451612", "aliases": [], "types": ["T044"], "canonical_name": "small conductance calcium-activated potassium channel inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel. [PMID:20562108]"}
{"concept_id": "C5451613", "aliases": [], "types": ["T044"], "canonical_name": "all-trans-phytoene synthase activity", "definition": "Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate. [PMID:12641468, PMID:7896759]"}
{"concept_id": "C5451614", "aliases": [], "types": ["T044"], "canonical_name": "aldehyde dehydrogenase (NAD+) inhibitor activity", "definition": "Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+). [PMID:33495566]"}
{"concept_id": "C5451615", "aliases": [], "types": ["T043"], "canonical_name": "inflammasome complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form an inflammasome complex. [PMID:33420028, PMID:33420033, PMID:33542150]"}
{"concept_id": "C5451616", "aliases": [], "types": ["T043"], "canonical_name": "CARD8 inflammasome complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a CARD8 inflammasome complex. [PMID:33420028, PMID:33420033, PMID:33542150]"}
{"concept_id": "C5451617", "aliases": [], "types": ["T043"], "canonical_name": "neutrophil dispersal", "definition": "The movement of a neutrophil away from the site of wound or infection following its initial migration to the site. [PMID:31727891]"}
{"concept_id": "C5451618", "aliases": [], "types": ["T043"], "canonical_name": "copper import into the mitochondrion", "definition": "The process in which copper is transported from the cytosol into the mitochondrial matrix. [PMID:32979421]"}
{"concept_id": "C5451619", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-37 production", "definition": "Any process that modulates the frequency, rate or extent of interleukin-37 production. [GOC:aruk, PMID:30362558]"}
{"concept_id": "C5451620", "aliases": [], "types": ["T040"], "canonical_name": "interleukin-37 production", "definition": "The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:aruk, PMID:30362558]"}
{"concept_id": "C5451621", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-37 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production. [GOC:aruk, PMID:30362558]"}
{"concept_id": "C5451622", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-37 production", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-37 production. [GOC:aruk]"}
{"concept_id": "C5451623", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-17A production", "definition": "Any process that modulates the frequency, rate or extent of interleukin-17A production. [GOC:aruk, PMID:27901018]"}
{"concept_id": "C5451624", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-17A production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A production. [GOC:aruk, PMID:27901018]"}
{"concept_id": "C5451625", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-17A production", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-17A production. [GOC:aruk]"}
{"concept_id": "C5451626", "aliases": [], "types": ["T040"], "canonical_name": "regulation of interleukin-32 production", "definition": "Any process that modulates the frequency, rate or extent of interleukin-32 production. [GOC:aruk, PMID:23729669]"}
{"concept_id": "C5451627", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation of interleukin-32 production", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 production. [GOC:aruk, PMID:23729669]"}
{"concept_id": "C5451628", "aliases": [], "types": ["T040"], "canonical_name": "positive regulation of interleukin-32 production", "definition": "Any process that activates or increases the frequency, rate or extent of interleukin-32 production. [GOC:aruk]"}
{"concept_id": "C5451629", "aliases": [], "types": ["T044"], "canonical_name": "extrasynaptic signaling via GABA", "definition": "Cell-cell signaling that starts with the activation of extrasynaptic GABA receptors in neurons through binding of ambient gamma-aminobutyric acid present in the extracellular fluid. [PMID:23038269, PMID:9364051]"}
{"concept_id": "C5451630", "aliases": [], "types": ["T040"], "canonical_name": "regulation of glial cell-derived neurotrophic factor production", "definition": "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor production. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C5451631", "aliases": ["positive regulation of GDNF production"], "types": ["T043"], "canonical_name": "positive regulation of glial cell-derived neurotrophic factor production", "definition": "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor production. [GOC:TermGenie, GOC:yaf]"}
{"concept_id": "C5451632", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type tungstate transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out). [GOC:TermGenie, PMID:16952940, PMID:21784948, RHEA:35027]"}
{"concept_id": "C5451633", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type doxorubicin transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + doxorubicin(in) = ADP + phosphate + doxorubicin(out). [GOC:TermGenie, PMID:12057006, PMID:15090538]"}
{"concept_id": "C5451634", "aliases": [], "types": ["T043"], "canonical_name": "cytotoxic T cell pyroptotic process", "definition": "Any pyroptotic process in a cytotoxic T cell. [GOC:nhn, GOC:TermGenie, PMID:32299851]"}
{"concept_id": "C5451635", "aliases": [], "types": ["T044"], "canonical_name": "iron-sulfur cluster transmembrane transport", "definition": "A process in which an iron-sulfur cluster is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:dph, GOC:TermGenie, PMID:19810706]"}
{"concept_id": "C5451636", "aliases": [], "types": ["T040"], "canonical_name": "regulation of endothelin production", "definition": "Any process that modulates the frequency, rate or extent of endothelin production. [GO_REF:0000058, GOC:TermGenie, PMID:15560120]"}
{"concept_id": "C5451637", "aliases": [], "types": ["T044"], "canonical_name": "regulation of small GTPase binding", "definition": "Any process that modulates the frequency, rate or extent of small GTPase binding. [GO_REF:0000059, GOC:TermGenie, PMID:15798216]"}
{"concept_id": "C5451638", "aliases": ["upregulation of small GTPase binding", "up regulation of small GTPase binding", "up-regulation of small GTPase binding"], "types": ["T044"], "canonical_name": "positive regulation of small GTPase binding", "definition": "Any process that activates or increases the frequency, rate or extent of small GTPase binding. [GO_REF:0000059, GOC:TermGenie, PMID:15798216]"}
{"concept_id": "C5451639", "aliases": [], "types": ["T040"], "canonical_name": "endothelin production", "definition": "The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. [PMID:15560120]"}
{"concept_id": "C5451640", "aliases": [], "types": ["T044"], "canonical_name": "S-(hydroxymethyl)glutathione dehydrogenase NAD activity", "definition": "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+. [RHEA:19985]"}
{"concept_id": "C5550967", "aliases": [], "types": ["T043"], "definition": "A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. [GOC:BHF]", "canonical_name": "replicative senescence"}
{"concept_id": "C5574732", "aliases": ["muscle tendon junction"], "types": ["T026"], "definition": "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons. [GOC:mtg_muscle, PMID:12842007]", "canonical_name": "myotendinous junction"}
{"concept_id": "C5574868", "aliases": [], "types": ["T044"], "canonical_name": "methanol:NAD+ oxidoreductase activity"}
{"concept_id": "C5574978", "aliases": [], "types": ["T043"], "definition": "The multiplication of mitochondria, resulting in the expansion of the number of mitochondria within a cell. [PMID:28301064]", "canonical_name": "mitochondrial proliferation"}
{"concept_id": "C5575084", "aliases": [], "types": ["T044"], "canonical_name": "small G-protein"}
{"concept_id": "C5575085", "aliases": ["small GTPase"], "types": ["T044"], "canonical_name": "small GTPase activity"}
{"concept_id": "C5575116", "aliases": [], "types": ["T045"], "canonical_name": "attachment of telomeres to nuclear envelope"}
{"concept_id": "C5575117", "aliases": [], "types": ["T044"], "canonical_name": "(4-aminobutyl)lysine synthase"}
{"concept_id": "C5575130", "aliases": [], "types": ["T044"], "canonical_name": "Glucosidase II"}
{"concept_id": "C5575570", "aliases": ["ADA complex", "ADA HAT complex", "ADA HAT complex location", "ADA complex location", "scADA", "ADA histone acetyltransferase complex location"], "types": ["T026"], "definition": "A chromatin remodelling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex. [GOC:bhm, PMID:21734642, PMID:28966424]", "canonical_name": "ADA histone acetyltransferase complex"}
{"concept_id": "C5576054", "aliases": [], "types": ["T044"], "canonical_name": "Ras superfamily protein"}
{"concept_id": "C5672474", "aliases": ["PCAF complex location"], "types": ["T026"], "canonical_name": "PCAF complex"}
{"concept_id": "C5672475", "aliases": ["PCAF histone acetylase-associated complex location"], "types": ["T026"], "canonical_name": "PCAF histone acetylase-associated complex"}
{"concept_id": "C5672476", "aliases": ["SPT3-TAF9-GCN5 acetylase complex location"], "types": ["T026"], "canonical_name": "SPT3-TAF9-GCN5 acetylase complex"}
{"concept_id": "C5672477", "aliases": ["SPT3-TAF9-PCAF acetylase complex location"], "types": ["T026"], "canonical_name": "SPT3-TAF9-PCAF acetylase complex"}
{"concept_id": "C5672478", "aliases": ["STAGA coactivator complex location"], "types": ["T026"], "canonical_name": "STAGA coactivator complex"}
{"concept_id": "C5672479", "aliases": ["STAGA complex location"], "types": ["T026"], "canonical_name": "STAGA complex"}
{"concept_id": "C5672480", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase regulatory region DNA binding"}
{"concept_id": "C5672481", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding"}
{"concept_id": "C5672482", "aliases": [], "types": ["T045"], "canonical_name": "eubacterial-type RNA polymerase regulatory region DNA binding"}
{"concept_id": "C5672483", "aliases": [], "types": ["T045"], "canonical_name": "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding"}
{"concept_id": "C5672484", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type cis-regulatory region sequence-specific DNA binding"}
{"concept_id": "C5672485", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type proximal promoter sequence-specific DNA binding"}
{"concept_id": "C5672486", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding"}
{"concept_id": "C5672487", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase enhancer sequence-specific DNA binding"}
{"concept_id": "C5672488", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding"}
{"concept_id": "C5672489", "aliases": [], "types": ["T045"], "canonical_name": "eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding"}
{"concept_id": "C5672490", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase core promoter sequence-specific DNA binding"}
{"concept_id": "C5672491", "aliases": [], "types": ["T045"], "canonical_name": "eubacterial-type RNA polymerase core promoter sequence-specific DNA binding"}
{"concept_id": "C5672492", "aliases": [], "types": ["T045"], "canonical_name": "promoter clearance from bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672493", "aliases": [], "types": ["T045"], "canonical_name": "transcription open complex formation at bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672494", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional open complex formation at bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672495", "aliases": [], "types": ["T045"], "canonical_name": "transcriptional start site selection at bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672496", "aliases": [], "types": ["T045"], "canonical_name": "maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672497", "aliases": [], "types": ["T044"], "canonical_name": "glycolate oxidase activity"}
{"concept_id": "C5672498", "aliases": [], "types": ["T044"], "canonical_name": "long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity"}
{"concept_id": "C5672499", "aliases": [], "types": ["T044"], "canonical_name": "medium-chain-(S)-2-hydroxy-acid oxidase activity"}
{"concept_id": "C5672500", "aliases": [], "types": ["T044"], "canonical_name": "very-long-chain-(S)-2-hydroxy-acid oxidase activity"}
{"concept_id": "C5672501", "aliases": [], "types": ["T044"], "canonical_name": "retinal oxidase activity"}
{"concept_id": "C5672502", "aliases": [], "types": ["T044"], "canonical_name": "dopamine monooxygenase activity"}
{"concept_id": "C5672503", "aliases": [], "types": ["T044"], "canonical_name": "L-DOPA monooxygenase activity"}
{"concept_id": "C5672504", "aliases": [], "types": ["T044"], "canonical_name": "L-dopa oxidase activity"}
{"concept_id": "C5672505", "aliases": [], "types": ["T044"], "canonical_name": "calmodulin-activated cyclic-nucleotide dual specificity phosphodiesterase activity"}
{"concept_id": "C5672506", "aliases": [], "types": ["T044"], "canonical_name": "dihydrothymine dehydrogenase (NAD+) activity"}
{"concept_id": "C5672507", "aliases": ["KAS II", "KASII", "beta-ketoacyl-acyl-carrier-protein synthase II activity"], "types": ["T044"], "canonical_name": "beta-ketoacyl-ACP synthase II activity"}
{"concept_id": "C5672508", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethylglutaryl-CoA reductase activity"}
{"concept_id": "C5672509", "aliases": [], "types": ["T044"], "canonical_name": "alpha-amylase activity (releasing maltohexaose)"}
{"concept_id": "C5672510", "aliases": [], "types": ["T044"], "canonical_name": "phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)"}
{"concept_id": "C5672511", "aliases": [], "types": ["T044"], "canonical_name": "phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)"}
{"concept_id": "C5672512", "aliases": [], "types": ["T044"], "canonical_name": "protein threonine kinase activity"}
{"concept_id": "C5672513", "aliases": [], "types": ["T044"], "canonical_name": "protein phosphatase-2C"}
{"concept_id": "C5672514", "aliases": [], "types": ["T044"], "canonical_name": "protein serine phosphatase activity"}
{"concept_id": "C5672515", "aliases": [], "types": ["T044"], "canonical_name": "protein threonine phosphatase activity"}
{"concept_id": "C5672516", "aliases": [], "types": ["T044"], "canonical_name": "pentose phosphate epimerase (PPE)"}
{"concept_id": "C5672517", "aliases": [], "types": ["T044"], "canonical_name": "glutamate transmembrane transporter activity"}
{"concept_id": "C5672518", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication-independent nuclesome assembly"}
{"concept_id": "C5672519", "aliases": ["ATP-dependent chromatin remodelling"], "types": ["T045"], "canonical_name": "ATP-dependent chromatin remodeling"}
{"concept_id": "C5672520", "aliases": [], "types": ["T045"], "canonical_name": "bacterial transcription"}
{"concept_id": "C5672521", "aliases": [], "types": ["T045"], "canonical_name": "transcription from bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672522", "aliases": [], "types": ["T045"], "canonical_name": "transcription initiation from bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672523", "aliases": [], "types": ["T045"], "canonical_name": "transcription termination from bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672524", "aliases": [], "types": ["T045"], "canonical_name": "RNA elongation from bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672525", "aliases": [], "types": ["T045"], "canonical_name": "transcription elongation from bacterial-type RNA polymerase promoter"}
{"concept_id": "C5672526", "aliases": [], "types": ["T043"], "canonical_name": "channel localizer activity"}
{"concept_id": "C5672527", "aliases": [], "types": ["T045"], "canonical_name": "transcription regulator binding"}
{"concept_id": "C5672528", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 3'-O-beta-D-glucopyranoside hydrolase activity"}
{"concept_id": "C5672529", "aliases": [], "types": ["T044"], "canonical_name": "quercetin 4'-O-beta-D-glucopyranoside hydrolase activity"}
{"concept_id": "C5672530", "aliases": [], "types": ["T044"], "canonical_name": "ammonium channel activity"}
{"concept_id": "C5672531", "aliases": [], "types": ["T044"], "canonical_name": "naphthoate synthase activity"}
{"concept_id": "C5672532", "aliases": [], "types": ["T044"], "canonical_name": "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity"}
{"concept_id": "C5672533", "aliases": [], "types": ["T044"], "canonical_name": "hydroperoxide dehydratase activity"}
{"concept_id": "C5672534", "aliases": [], "types": ["T044"], "canonical_name": "hydroperoxide isomerase activity"}
{"concept_id": "C5672535", "aliases": [], "types": ["T040"], "canonical_name": "neural rod cavitation"}
{"concept_id": "C5672536", "aliases": [], "types": ["T040"], "canonical_name": "medullary rod cavitation"}
{"concept_id": "C5672537", "aliases": [], "types": ["T040"], "canonical_name": "secondary neural tube rod cavitation"}
{"concept_id": "C5672538", "aliases": ["LPS export"], "types": ["T043"], "canonical_name": "lipopolysaccharide export"}
{"concept_id": "C5672539", "aliases": [], "types": ["T044"], "canonical_name": "4-alpha-D-glucan maltohydrolase activity"}
{"concept_id": "C5672540", "aliases": [], "types": ["T044"], "canonical_name": "ATP monophosphatase activity"}
{"concept_id": "C5672541", "aliases": [], "types": ["T044"], "canonical_name": "Smt3-protein conjugation"}
{"concept_id": "C5672542", "aliases": [], "types": ["T044"], "canonical_name": "Smt3p-protein conjugation"}
{"concept_id": "C5672543", "aliases": [], "types": ["T044"], "canonical_name": "fuca(1,3)-glycosidic linkage formation"}
{"concept_id": "C5672544", "aliases": [], "types": ["T044"], "canonical_name": "muconate lactonizing enzyme I activity"}
{"concept_id": "C5672545", "aliases": [], "types": ["T038"], "canonical_name": "evasion by virus of host immune response"}
{"concept_id": "C5672546", "aliases": [], "types": ["T038"], "canonical_name": "evasion or tolerance by virus of host immune response"}
{"concept_id": "C5672547", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of extracellular antiviral response"}
{"concept_id": "C5672548", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation by virus of extracellular antiviral response"}
{"concept_id": "C5672549", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation by virus of intracellular antiviral response"}
{"concept_id": "C5672550", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of host extracellular antiviral response by virus"}
{"concept_id": "C5672551", "aliases": [], "types": ["T038"], "canonical_name": "negative regulation of host intracellular antiviral response by virus"}
{"concept_id": "C5672552", "aliases": ["suppression by virus of host extracellular antiviral response"], "types": ["T038"], "canonical_name": "suppression of host extracellular antiviral response by virus"}
{"concept_id": "C5672553", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host immune response"}
{"concept_id": "C5672554", "aliases": ["suppression by virus of host intracellular antiviral response"], "types": ["T038"], "canonical_name": "suppression of host intracellular antiviral response by virus"}
{"concept_id": "C5672555", "aliases": [], "types": ["T038"], "canonical_name": "viral inhibition of intracellular antiviral response"}
{"concept_id": "C5672556", "aliases": [], "types": ["T040"], "canonical_name": "multi-organism reproductive behavior"}
{"concept_id": "C5672557", "aliases": [], "types": ["T043"], "canonical_name": "divalent metal ion export"}
{"concept_id": "C5672558", "aliases": [], "types": ["T043"], "canonical_name": "metal ion export"}
{"concept_id": "C5672559", "aliases": [], "types": ["T045"], "canonical_name": "production of siRNA"}
{"concept_id": "C5672560", "aliases": ["production of siRNA involved in gene silencing by small RNA"], "types": ["T045"], "canonical_name": "production of siRNA involved in PTGS"}
{"concept_id": "C5672561", "aliases": [], "types": ["T045"], "canonical_name": "primary miRNA methylation"}
{"concept_id": "C5672562", "aliases": [], "types": ["T045"], "canonical_name": "chromatin maintenance"}
{"concept_id": "C5672563", "aliases": ["cellular protein complex localisation"], "types": ["T043"], "canonical_name": "cellular protein complex localization"}
{"concept_id": "C5672564", "aliases": [], "types": ["T043"], "canonical_name": "cellular protein-containing complex localization"}
{"concept_id": "C5672565", "aliases": [], "types": ["T043"], "canonical_name": "establishment and maintenance of cellular protein complex localization"}
{"concept_id": "C5672566", "aliases": [], "types": ["T045"], "canonical_name": "heterochromatic silencing"}
{"concept_id": "C5672567", "aliases": [], "types": ["T045"], "canonical_name": "heterochromatin maintenance"}
{"concept_id": "C5672568", "aliases": [], "types": ["T045"], "canonical_name": "regulation of chromatin silencing at telomere"}
{"concept_id": "C5672569", "aliases": [], "types": ["T045"], "canonical_name": "regulation of subtelomeric heterochromatin assembly"}
{"concept_id": "C5672570", "aliases": [], "types": ["T043"], "canonical_name": "cellular protein complex disassembly"}
{"concept_id": "C5672571", "aliases": [], "types": ["T045"], "canonical_name": "regulation of extent of heterochromatin assembly"}
{"concept_id": "C5672572", "aliases": [], "types": ["T045"], "canonical_name": "regulation of heterochromatin spreading"}
{"concept_id": "C5672573", "aliases": [], "types": ["T044"], "canonical_name": "aspartate dehydrogenase NAD activity"}
{"concept_id": "C5672574", "aliases": [], "types": ["T044"], "canonical_name": "aspartate dehydrogenase NADP activity"}
{"concept_id": "C5672575", "aliases": [], "types": ["T044"], "canonical_name": "24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity"}
{"concept_id": "C5672576", "aliases": [], "types": ["T044"], "canonical_name": "octanoyl transferase activity (acting on glycine-cleavage complex H protein)"}
{"concept_id": "C5672577", "aliases": [], "types": ["T044"], "canonical_name": "deoxycholoyl-CoA transferase activity"}
{"concept_id": "C5672578", "aliases": ["double-stranded RNA fragmentation"], "types": ["T045"], "canonical_name": "dsRNA fragmentation"}
{"concept_id": "C5672579", "aliases": [], "types": ["T045"], "canonical_name": "dsRNA processing"}
{"concept_id": "C5672580", "aliases": ["histone H3-K4me3 demethylase activity"], "types": ["T044"], "canonical_name": "H3K4me3 demethylase activity"}
{"concept_id": "C5672581", "aliases": ["histone H3K4me2 demethylase activity"], "types": ["T044"], "canonical_name": "histone H3-K4me2 demethylase activity"}
{"concept_id": "C5672582", "aliases": ["gene silencing by mRNA cleavage"], "types": ["T045"], "canonical_name": "gene silencing by mRNA cleavage"}
{"concept_id": "C5672583", "aliases": [], "types": ["T044"], "canonical_name": "1-ethyladenine demethylase activity"}
{"concept_id": "C5672584", "aliases": [], "types": ["T044"], "canonical_name": "N1-methyladenine demethylase activity"}
{"concept_id": "C5672585", "aliases": [], "types": ["T044"], "canonical_name": "N3-methylcytosine demethylase activity"}
{"concept_id": "C5672586", "aliases": [], "types": ["T043"], "canonical_name": "ejection from host"}
{"concept_id": "C5672587", "aliases": [], "types": ["T040"], "canonical_name": "exit from host"}
{"concept_id": "C5672588", "aliases": [], "types": ["T043"], "canonical_name": "oxytocin biosynthesis"}
{"concept_id": "C5672589", "aliases": [], "types": ["T044"], "canonical_name": "9-beta-stemod-13(17)-ene oxidase activity"}
{"concept_id": "C5672590", "aliases": [], "types": ["T044"], "canonical_name": "DNA rewinding activity"}
{"concept_id": "C5672591", "aliases": [], "types": ["T044"], "canonical_name": "O-phosphoserine phosphohydrolase activity"}
{"concept_id": "C5672592", "aliases": [], "types": ["T044"], "canonical_name": "phosphoserine phosphatase activity"}
{"concept_id": "C5672593", "aliases": ["NIK-IKK signaling pathway"], "types": ["T044"], "canonical_name": "NIK-IKK cascade"}
{"concept_id": "C5672594", "aliases": [], "types": ["T044"], "canonical_name": "NIK-IKK kinase cascade"}
{"concept_id": "C5672595", "aliases": [], "types": ["T044"], "canonical_name": "NIK-IKK-alpha cascade"}
{"concept_id": "C5672596", "aliases": [], "types": ["T038"], "canonical_name": "inhibition by virus of host RIG-I signaling"}
{"concept_id": "C5672597", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host DDX58 signaling pathway"}
{"concept_id": "C5672598", "aliases": [], "types": ["T038"], "canonical_name": "inhibition by virus of host MDA-5 signaling"}
{"concept_id": "C5672599", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host IFIH1 signaling pathway"}
{"concept_id": "C5672600", "aliases": ["suppression by virus of host MDA-5 signalling pathway"], "types": ["T038"], "canonical_name": "suppression by virus of host MDA-5 signaling pathway"}
{"concept_id": "C5672601", "aliases": [], "types": ["T038"], "canonical_name": "cleavage by virus of host mRNA"}
{"concept_id": "C5672602", "aliases": [], "types": ["T045"], "canonical_name": "host mRNA cleavage by viral endoribonuclease"}
{"concept_id": "C5672603", "aliases": [], "types": ["T038"], "canonical_name": "induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process"}
{"concept_id": "C5672604", "aliases": [], "types": ["T038"], "canonical_name": "induction by virus of host endonucleolytic cleavage-dependent mRNA decay"}
{"concept_id": "C5672605", "aliases": [], "types": ["T038"], "canonical_name": "viral endoribonuclease activity involved in degradation of host mRNA"}
{"concept_id": "C5672606", "aliases": [], "types": ["T045"], "canonical_name": "RNA-mediated gene silencing by inhibition of translation"}
{"concept_id": "C5672607", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cyclin breakdown"}
{"concept_id": "C5672608", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cyclin catabolic process"}
{"concept_id": "C5672609", "aliases": [], "types": ["T043"], "canonical_name": "regulation of cyclin catabolism"}
{"concept_id": "C5672610", "aliases": ["regulation of degradation of cyclin"], "types": ["T043"], "canonical_name": "regulation of cyclin degradation"}
{"concept_id": "C5672611", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular protein breakdown"}
{"concept_id": "C5672612", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular protein catabolic process"}
{"concept_id": "C5672613", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular protein catabolism"}
{"concept_id": "C5672614", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular protein degradation"}
{"concept_id": "C5672615", "aliases": [], "types": ["T043"], "canonical_name": "drug breakdown"}
{"concept_id": "C5672616", "aliases": [], "types": ["T043"], "canonical_name": "drug catabolic process"}
{"concept_id": "C5672617", "aliases": [], "types": ["T043"], "canonical_name": "drug catabolism"}
{"concept_id": "C5672618", "aliases": [], "types": ["T043"], "canonical_name": "drug degradation"}
{"concept_id": "C5672619", "aliases": [], "types": ["T043"], "canonical_name": "exogenous drug breakdown"}
{"concept_id": "C5672620", "aliases": [], "types": ["T043"], "canonical_name": "exogenous drug catabolic process"}
{"concept_id": "C5672621", "aliases": [], "types": ["T043"], "canonical_name": "exogenous drug catabolism"}
{"concept_id": "C5672622", "aliases": [], "types": ["T043"], "canonical_name": "exogenous drug degradation"}
{"concept_id": "C5672623", "aliases": [], "types": ["T026"], "canonical_name": "biological condensate"}
{"concept_id": "C5672624", "aliases": ["methylcobamide:CoM methyltransferase activity", "methylcobamide:coenzyme M methyltransferase activity"], "types": ["T044"], "canonical_name": "methylcobamide:CoM methyltransferase activity"}
{"concept_id": "C5672625", "aliases": [], "types": ["T040"], "canonical_name": "movement in host environment"}
{"concept_id": "C5672626", "aliases": [], "types": ["T038"], "canonical_name": "inhibition of viral release from host cell"}
{"concept_id": "C5672627", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular protein breakdown"}
{"concept_id": "C5672628", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular protein catabolic process"}
{"concept_id": "C5672629", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular protein catabolism"}
{"concept_id": "C5672630", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular protein degradation"}
{"concept_id": "C5672631", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cyclin breakdown"}
{"concept_id": "C5672632", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cyclin catabolic process"}
{"concept_id": "C5672633", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cyclin catabolism"}
{"concept_id": "C5672634", "aliases": ["positive regulation of degradation of cyclin"], "types": ["T043"], "canonical_name": "positive regulation of cyclin degradation"}
{"concept_id": "C5672635", "aliases": [], "types": ["T045"], "canonical_name": "euchromatin assembly"}
{"concept_id": "C5672636", "aliases": ["euchromatin organization"], "types": ["T045"], "canonical_name": "euchromatin organisation"}
{"concept_id": "C5672637", "aliases": [], "types": ["T045"], "canonical_name": "long-term maintenance of gene activation"}
{"concept_id": "C5672638", "aliases": [], "types": ["T043"], "canonical_name": "xenobiotic export"}
{"concept_id": "C5672639", "aliases": [], "types": ["T046"], "canonical_name": "suppression by virus of host tapasin activity"}
{"concept_id": "C5672640", "aliases": [], "types": ["T044"], "canonical_name": "aromatic 2-oxoacid reductase activity"}
{"concept_id": "C5672641", "aliases": [], "types": ["T044"], "canonical_name": "phenylpyruvate reductase activity"}
{"concept_id": "C5672642", "aliases": [], "types": ["T044"], "canonical_name": "3-carboxymuconate cycloisomerase type II activity"}
{"concept_id": "C5672643", "aliases": [], "types": ["T043"], "canonical_name": "activation of cellular protein metabolic process"}
{"concept_id": "C5672644", "aliases": [], "types": ["T043"], "canonical_name": "stimulation of cellular protein metabolic process"}
{"concept_id": "C5672645", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of cellular protein metabolic process"}
{"concept_id": "C5672646", "aliases": [], "types": ["T044"], "canonical_name": "histone H3K36 demethylase activity"}
{"concept_id": "C5672647", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by symbiont of host molecular function"}
{"concept_id": "C5672648", "aliases": ["down-regulation by host of symbiont protein function", "downregulation by host of symbiont protein function"], "types": ["T040"], "canonical_name": "down regulation by host of symbiont protein function"}
{"concept_id": "C5672649", "aliases": [], "types": ["T040"], "canonical_name": "inhibition by host of symbiont protein function"}
{"concept_id": "C5672650", "aliases": [], "types": ["T040"], "canonical_name": "inhibition of symbiont protein function"}
{"concept_id": "C5672651", "aliases": [], "types": ["T040"], "canonical_name": "negative regulation by host of symbiont molecular function"}
{"concept_id": "C5672652", "aliases": [], "types": ["T044"], "canonical_name": "antheraxanthin epoxidase activity"}
{"concept_id": "C5672653", "aliases": [], "types": ["T044"], "canonical_name": "zeaxanthin epoxidase [overall] activity"}
{"concept_id": "C5672654", "aliases": ["2-chloroethanol:cytochrome c oxidoreductase activity"], "types": ["T044"], "canonical_name": "2-chloroethanol cytochrome-c oxidoreductase activity"}
{"concept_id": "C5672655", "aliases": ["ethanol:cytochrome c oxidoreductase activity"], "types": ["T044"], "canonical_name": "ethanol cytochrome-c oxidoreductase activity"}
{"concept_id": "C5672656", "aliases": [], "types": ["T044"], "canonical_name": "methanol ferricytochrome-c oxidoreductase activity"}
{"concept_id": "C5672657", "aliases": ["alcohol:acceptor oxidoreductase activity"], "types": ["T044"], "canonical_name": "alcohol:(acceptor) oxidoreductase activity"}
{"concept_id": "C5672658", "aliases": [], "types": ["T043"], "canonical_name": "self-compatibility"}
{"concept_id": "C5672659", "aliases": [], "types": ["T044"], "canonical_name": "arginine permease activity"}
{"concept_id": "C5672660", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent protein-nucleic acid complex displacement activity"}
{"concept_id": "C5672661", "aliases": [], "types": ["T044"], "canonical_name": "cellular macromolecule complex assembly"}
{"concept_id": "C5672662", "aliases": [], "types": ["T043"], "canonical_name": "cellular protein-containing complex assembly"}
{"concept_id": "C5672663", "aliases": [], "types": ["T043"], "canonical_name": "actin polymerization-dependent cell motility involved in migration of symbiont in host"}
{"concept_id": "C5672664", "aliases": [], "types": ["T044"], "canonical_name": "bacterial-type RNA polymerase preinitiation complex assembly"}
{"concept_id": "C5672665", "aliases": [], "types": ["T044"], "canonical_name": "bacterial-type RNA polymerase transcription PIC formation"}
{"concept_id": "C5672666", "aliases": [], "types": ["T045"], "canonical_name": "bacterial-type RNA polymerase transcriptional preinitiation complex formation"}
{"concept_id": "C5672667", "aliases": ["sncRNA processing"], "types": ["T045"], "canonical_name": "scnRNA production"}
{"concept_id": "C5672668", "aliases": [], "types": ["T045"], "canonical_name": "small regulatory ncRNA maturation"}
{"concept_id": "C5672669", "aliases": [], "types": ["T045"], "canonical_name": "regulation of production of siRNA involved in gene silencing by small RNA"}
{"concept_id": "C5672670", "aliases": ["regulation of production of siRNA involved in post-transcriptional gene silencing by RNA"], "types": ["T045"], "canonical_name": "regulation of production of siRNA involved in PTGS"}
{"concept_id": "C5672671", "aliases": [], "types": ["T045"], "canonical_name": "miRISC assembly"}
{"concept_id": "C5672672", "aliases": [], "types": ["T045"], "canonical_name": "miRNA loading onto RISC"}
{"concept_id": "C5672673", "aliases": [], "types": ["T045"], "canonical_name": "siRNA loading onto RISC involved in gene silencing by small RNA"}
{"concept_id": "C5672674", "aliases": [], "types": ["T045"], "canonical_name": "siRNA loading onto RISC involved in RNA interference"}
{"concept_id": "C5672675", "aliases": [], "types": ["T045"], "canonical_name": "nuclear retention of pre-mRNA at the site of transcription"}
{"concept_id": "C5672676", "aliases": [], "types": ["T045"], "canonical_name": "nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription"}
{"concept_id": "C5672677", "aliases": [], "types": ["T045"], "canonical_name": "nuclear retention of unspliced pre-mRNA at the site of transcription"}
{"concept_id": "C5672678", "aliases": [], "types": ["T044"], "canonical_name": "histone H3K27me2 demethylase activity"}
{"concept_id": "C5672679", "aliases": [], "types": ["T044"], "canonical_name": "histone H3K27me3 demethylase activity"}
{"concept_id": "C5672680", "aliases": [], "types": ["T043"], "canonical_name": "peptide pheromone export involved in positive regulation of conjugation with cellular fusion"}
{"concept_id": "C5672681", "aliases": [], "types": ["T043"], "canonical_name": "peptide pheromone export involved in regulation of conjugation"}
{"concept_id": "C5672682", "aliases": [], "types": ["T043"], "canonical_name": "ammonia transport"}
{"concept_id": "C5672683", "aliases": [], "types": ["T044"], "canonical_name": "toxin-antitoxin pair type I binding"}
{"concept_id": "C5672684", "aliases": [], "types": ["T044"], "canonical_name": "cytosolic calcium ion transport"}
{"concept_id": "C5672685", "aliases": [], "types": ["T038"], "canonical_name": "anti-CRISPR"}
{"concept_id": "C5672686", "aliases": [], "types": ["T045"], "canonical_name": "mRNA destabilization-mediated gene silencing"}
{"concept_id": "C5672687", "aliases": [], "types": ["T045"], "canonical_name": "RNA interference, targeting of mRNA for destruction"}
{"concept_id": "C5672688", "aliases": [], "types": ["T045"], "canonical_name": "targeting of mRNA for destruction involved in RNA interference"}
{"concept_id": "C5672689", "aliases": [], "types": ["T040"], "canonical_name": "non-reproductive fruiting body development"}
{"concept_id": "C5672690", "aliases": [], "types": ["T044"], "canonical_name": "germacrene A alcohol dehydrogenase activity"}
{"concept_id": "C5672691", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)+-protein-arginine ADP-ribosyltransferase activity"}
{"concept_id": "C5672692", "aliases": [], "types": ["T044"], "canonical_name": "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity"}
{"concept_id": "C5672693", "aliases": [], "types": ["T044"], "canonical_name": "NADP+-protein-arginine ADP-ribosyltransferase activity"}
{"concept_id": "C5672694", "aliases": ["sialyl-Lewis X biosynthetic process"], "types": ["T044"], "canonical_name": "sLeX biosynthetic process"}
{"concept_id": "C5672695", "aliases": [], "types": ["T044"], "canonical_name": "murein peptide ligase"}
{"concept_id": "C5672696", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of mitotic recombination involved in replication fork processing"}
{"concept_id": "C5672697", "aliases": [], "types": ["T044"], "canonical_name": "cytochrome P450 fatty acid omega-1 hydroxylase activity"}
{"concept_id": "C5672698", "aliases": [], "types": ["T043"], "canonical_name": "lateral pseudopodium suppression"}
{"concept_id": "C5672699", "aliases": ["associated with the nuclear pore"], "types": ["T026"], "canonical_name": "associated with the nuclear pore"}
{"concept_id": "C5672700", "aliases": ["protein unfoldase activity"], "types": ["T044"], "canonical_name": "protein unfoldase activity"}
{"concept_id": "C5672701", "aliases": [], "types": ["T045"], "canonical_name": "DNA looping"}
{"concept_id": "C5672702", "aliases": [], "types": ["T044"], "canonical_name": "beta-hydroxy-beta-methylglutaryl CoA-reductase activity"}
{"concept_id": "C5672703", "aliases": [], "types": ["T044"], "canonical_name": "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity"}
{"concept_id": "C5672704", "aliases": ["NET formation"], "types": ["T043"], "canonical_name": "neutrophic extracellular trap formation", "definition": "The aggregation, arrangement and bonding together of a set of components to form a neutrophil extracellular trap, a network of extracellular fibers primarily composed of DNA from neutrophils, which bind and neutralizes pathogens. [PMID:28267716]"}
{"concept_id": "C5672705", "aliases": [], "types": ["T044"], "canonical_name": "P450-containing system"}
{"concept_id": "C5672706", "aliases": [], "types": ["T040"], "canonical_name": "host tissue colonization"}
{"concept_id": "C5672707", "aliases": [], "types": ["T040"], "canonical_name": "plant tissue colonization"}
{"concept_id": "C5672708", "aliases": [], "types": ["T044"], "canonical_name": "nucleosome-activated ATPase activity"}
{"concept_id": "C5672709", "aliases": [], "types": ["T044"], "canonical_name": "nucleosome-dependent ATPase activity"}
{"concept_id": "C5672710", "aliases": [], "types": ["T044"], "canonical_name": "motor activity regulator activity"}
{"concept_id": "C5672711", "aliases": [], "types": ["T044"], "canonical_name": "motor activity activator activity"}
{"concept_id": "C5672712", "aliases": [], "types": ["T044"], "canonical_name": "motor activity inhibitor activity"}
{"concept_id": "C5672713", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent H3-H4 histone complex loader activity"}
{"concept_id": "C5672714", "aliases": [], "types": ["T044"], "canonical_name": "H3-H4 histone chaperone"}
{"concept_id": "C5672715", "aliases": [], "types": ["T044"], "canonical_name": "H3-H4 histone complex loader activity"}
{"concept_id": "C5672716", "aliases": [], "types": ["T045"], "canonical_name": "renaturation"}
{"concept_id": "C5672717", "aliases": ["Ada2/Gcn5/Ada3 transcription activator complex location"], "types": ["T026"], "canonical_name": "Ada2/Gcn5/Ada3 transcription activator complex"}
{"concept_id": "C5672718", "aliases": [], "types": ["T045"], "canonical_name": "chromatin maintenance during transcription elongation"}
{"concept_id": "C5672719", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent histone loader activity"}
{"concept_id": "C5672720", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent histone unloader activity"}
{"concept_id": "C5672721", "aliases": [], "types": ["T044"], "canonical_name": "histone loader activity"}
{"concept_id": "C5672722", "aliases": [], "types": ["T044"], "canonical_name": "histone loading activity"}
{"concept_id": "C5672723", "aliases": [], "types": ["T044"], "canonical_name": "histone unloader activity"}
{"concept_id": "C5672724", "aliases": [], "types": ["T044"], "canonical_name": "histone unloading activity"}
{"concept_id": "C5672725", "aliases": ["nucleosome remodeling activity"], "types": ["T044"], "canonical_name": "nucleosome remodeling activity"}
{"concept_id": "C5672726", "aliases": [], "types": ["T044"], "canonical_name": "histone H3K36me demethylase activity"}
{"concept_id": "C5672727", "aliases": ["histone H3K36me2 demethylase activity"], "types": ["T044"], "canonical_name": "histone H3K36me2 demethylase activity"}
{"concept_id": "C5672728", "aliases": [], "types": ["T044"], "canonical_name": "histone H3K36me3 demethylase activity"}
{"concept_id": "C5672729", "aliases": [], "types": ["T044"], "canonical_name": "histone H3K4me demethylase activity"}
{"concept_id": "C5672730", "aliases": ["histone H3K9me demethylase activity"], "types": ["T044"], "canonical_name": "histone H3K9me demethylase activity"}
{"concept_id": "C5672731", "aliases": ["histone H3K9me2 demethylase activity"], "types": ["T044"], "canonical_name": "histone H3K9me2 demethylase activity"}
{"concept_id": "C5672732", "aliases": [], "types": ["T044"], "canonical_name": "histone H3K9me3 demethylase activity"}
{"concept_id": "C5672733", "aliases": ["FNI", "Frizzled Nuclear Import Wnt Pathway"], "types": ["T044"], "canonical_name": "Frizzled Nuclear Import pathway", "definition": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by internalization and cleavage of the frizzled receptor to yeild a C-terminal fragment that is imported into the nucleus. The frizzled C-terminal fragment is incorporated into large ribonucleoprotein particles and stimulates their egress via nuclear budding. [PMID:22510459, PMID:22579286]"}
{"concept_id": "C5672734", "aliases": ["regulation of Frizzled Nuclear Import Wnt Pathway", "regulation of FNI"], "types": ["T044"], "canonical_name": "regulation of Frizzled Nuclear Import pathway", "definition": "Any process that modulates the frequency, rate or extent of a Frizzled Nuclear Import pathway. [PMID:22510459, PMID:22579286]"}
{"concept_id": "C5672735", "aliases": ["positive regulation of FNI", "positive regulation of Frizzled Nuclear Import Wnt Pathway"], "types": ["T044"], "canonical_name": "positive regulation of Frizzled Nuclear Import pathway", "definition": "Any process that activates or increases the frequency, rate or extent of a Frizzled Nuclear Import pathway. [PMID:22510459, PMID:22579286]"}
{"concept_id": "C5672736", "aliases": ["negative regulation of FNI", "negative regulation of Frizzled Nuclear Import Wnt Pathway"], "types": ["T044"], "canonical_name": "negative regulation of Frizzled Nuclear Import pathway", "definition": "Any process that stops, prevents, or reduces the frequency, rate or extent of a Frizzled Nuclear Import pathway. [PMID:22510459, PMID:22579286]"}
{"concept_id": "C5672737", "aliases": ["mycophenolic acid anabolism", "mycophenolic acid formation", "mycophenolic acid biosynthesis", "MPA formation", "mycophenolic acid synthesis", "MPA synthesis", "MPA anabolism", "MPA biosynthesis"], "types": ["T044"], "canonical_name": "mycophenolic acid biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of mycophenolic acid (MPA). MPA is the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893. [PMID:21398490, PMID:26751579, PMID:31209052]"}
{"concept_id": "C5672738", "aliases": ["GC_rich_promoter_region binding"], "types": ["T045"], "canonical_name": "GC rich promoter region binding"}
{"concept_id": "C5672739", "aliases": [], "types": ["T045"], "canonical_name": "GC-rich region binding"}
{"concept_id": "C5672740", "aliases": ["AREG production"], "types": ["T043"], "canonical_name": "amphiregulin production", "definition": "The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor. [PMID:24463227]"}
{"concept_id": "C5672741", "aliases": ["regulation of AREG production"], "types": ["T043"], "canonical_name": "regulation of amphiregulin production", "definition": "Any process that modulates the frequency, rate, or extent of production of amphiregulin. [PMID:24463227]"}
{"concept_id": "C5672742", "aliases": ["positive regulation of AREG production"], "types": ["T043"], "canonical_name": "positive regulation of amphiregulin production", "definition": "Any process that activates or increases the frequency, rate or extent of production of amphiregulin. [PMID:24463227]"}
{"concept_id": "C5672743", "aliases": [], "types": ["T039"], "canonical_name": "ammonia excretion"}
{"concept_id": "C5672744", "aliases": [], "types": ["T026"], "canonical_name": "protein nanocompartment"}
{"concept_id": "C5672745", "aliases": [], "types": ["T044"], "canonical_name": "histone demethylase activity (H3-K56 specific)"}
{"concept_id": "C5672746", "aliases": [], "types": ["T044"], "canonical_name": "histone H3K56me2 demethylase activity"}
{"concept_id": "C5672747", "aliases": [], "types": ["T044"], "canonical_name": "histone H3K56me3 demethylase activity"}
{"concept_id": "C5672748", "aliases": [], "types": ["T044"], "canonical_name": "calcium- and calmodulin-regulated 3',5'-cyclic-AMP phosphodiesterase activity"}
{"concept_id": "C5672749", "aliases": [], "types": ["T044"], "canonical_name": "calcium- and calmodulin-regulated cAMP phosphodiesterase activity"}
{"concept_id": "C5672750", "aliases": [], "types": ["T044"], "canonical_name": "protein-substrate adaptor activity"}
{"concept_id": "C5672751", "aliases": ["viriditoxin synthesis", "viriditoxin biosynthesis", "viriditoxin formation"], "types": ["T044"], "canonical_name": "viriditoxin anabolism"}
{"concept_id": "C5672752", "aliases": [], "types": ["T044"], "canonical_name": "glutamate uniporter activity"}
{"concept_id": "C5672753", "aliases": [], "types": ["T044"], "canonical_name": "histone citrullination"}
{"concept_id": "C5672754", "aliases": [], "types": ["T044"], "canonical_name": "orotate:organic anion antiporter activity"}
{"concept_id": "C5672755", "aliases": [], "types": ["T044"], "canonical_name": "urate:organic anion antiporter activity"}
{"concept_id": "C5672756", "aliases": [], "types": ["T044"], "canonical_name": "sodium/chloride-dependent glycine betaine transporter activity"}
{"concept_id": "C5672757", "aliases": [], "types": ["T043"], "canonical_name": "Fc receptor-mediated immune complex internalization"}
{"concept_id": "C5672758", "aliases": ["MZT"], "types": ["T045"], "canonical_name": "maternal-to-zygotic transition of gene expression", "definition": "Any process that modulates the frequency, rate or extent of gene expression by which developmental control passes from the maternal genome to the zygotic genome. [PMID:19204068, PMID:32558204]"}
{"concept_id": "C5672759", "aliases": [], "types": ["T043"], "canonical_name": "secretion by cell decapitation"}
{"concept_id": "C5672760", "aliases": [], "types": ["T043"], "canonical_name": "secretion by membrane budding"}
{"concept_id": "C5672761", "aliases": [], "types": ["T045"], "canonical_name": "regulation of chromatin assembly or disassembly"}
{"concept_id": "C5672762", "aliases": [], "types": ["T043"], "canonical_name": "regulation of chromatin assembly/disassembly"}
{"concept_id": "C5672763", "aliases": [], "types": ["T045"], "canonical_name": "mRNA binding translation repressor activity"}
{"concept_id": "C5672764", "aliases": [], "types": ["T045"], "canonical_name": "RNA binding involved in cosuppression"}
{"concept_id": "C5672765", "aliases": ["RNA binding involved in post-transcriptional gene silencing", "RNA binding involved in posttranscriptional gene silencing"], "types": ["T045"], "canonical_name": "RNA binding involved in PTGS"}
{"concept_id": "C5672766", "aliases": [], "types": ["T045"], "canonical_name": "RNA binding involved in quelling"}
{"concept_id": "C5672767", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of production of siRNA involved in post-transcriptional gene silencing by RNA"}
{"concept_id": "C5672768", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of production of siRNA involved in post-transcriptional gene silencing by RNA"}
{"concept_id": "C5672769", "aliases": [], "types": ["T043"], "canonical_name": "arginine transport"}
{"concept_id": "C5672770", "aliases": [], "types": ["T044"], "canonical_name": "L-arginine import"}
{"concept_id": "C5672771", "aliases": [], "types": ["T043"], "canonical_name": "L-arginine transport"}
{"concept_id": "C5672772", "aliases": [], "types": ["T043"], "canonical_name": "L-arginine uptake"}
{"concept_id": "C5672773", "aliases": ["downregulation of chromatin assembly or disassembly", "down-regulation of chromatin assembly or disassembly"], "types": ["T043"], "canonical_name": "down regulation of chromatin assembly or disassembly"}
{"concept_id": "C5672774", "aliases": [], "types": ["T043"], "canonical_name": "inhibition of chromatin assembly or disassembly"}
{"concept_id": "C5672775", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of chromatin assembly or disassembly"}
{"concept_id": "C5672776", "aliases": [], "types": ["T045"], "canonical_name": "activation of chromatin assembly or disassembly"}
{"concept_id": "C5672777", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of chromatin assembly or disassembly"}
{"concept_id": "C5672778", "aliases": [], "types": ["T045"], "canonical_name": "positive regulation of chromatin assembly/disassembly"}
{"concept_id": "C5672779", "aliases": [], "types": ["T045"], "canonical_name": "stimulation of chromatin assembly or disassembly"}
{"concept_id": "C5672780", "aliases": ["up-regulation of chromatin assembly or disassembly"], "types": ["T043"], "canonical_name": "up regulation of chromatin assembly or disassembly"}
{"concept_id": "C5672781", "aliases": [], "types": ["T043"], "canonical_name": "regulation of L-arginine import"}
{"concept_id": "C5672782", "aliases": [], "types": ["T044"], "canonical_name": "protein ADP-ribosyltransferase activity"}
{"concept_id": "C5672783", "aliases": [], "types": ["T045"], "canonical_name": "mitotic recombination involved in replication fork restart"}
{"concept_id": "C5672784", "aliases": [], "types": ["T045"], "canonical_name": "mitotic recombination involved in replication restart"}
{"concept_id": "C5672785", "aliases": ["Pex17p-Pex14p docking complex location"], "types": ["T026"], "canonical_name": "Pex17p-Pex14p docking complex"}
{"concept_id": "C5672786", "aliases": [], "types": ["T043"], "canonical_name": "fructose import"}
{"concept_id": "C5672787", "aliases": [], "types": ["T042"], "canonical_name": "ovarian senescence"}
{"concept_id": "C5672788", "aliases": [], "types": ["T044"], "canonical_name": "RNA N(1)-methyladenosine dioxygenase activity"}
{"concept_id": "C5672789", "aliases": [], "types": ["T043"], "canonical_name": "ammonium transport"}
{"concept_id": "C5672790", "aliases": [], "types": ["T043"], "canonical_name": "mitochondrial membrane fusion"}
{"concept_id": "C5672791", "aliases": [], "types": ["T043"], "canonical_name": "cellular response to drug"}
{"concept_id": "C5672792", "aliases": [], "types": ["T044"], "canonical_name": "SAICAR-lyase (fumarate forming) activity"}
{"concept_id": "C5672793", "aliases": [], "types": ["T045"], "canonical_name": "mitotic recombination involved in replication fork processing"}
{"concept_id": "C5672795", "aliases": ["bI4 intron splicing complex location"], "types": ["T026"], "canonical_name": "bI4 intron splicing complex", "definition": "A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing. [GOC:lnp, PMID:19622748]"}
{"concept_id": "C5672796", "aliases": ["bI3 intron splicing complex location"], "types": ["T026"], "canonical_name": "bI3 intron splicing complex", "definition": "Aprotein complex required for the splicing of intron 3 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI3 (which derives from one of the products of the splicing), the MRS1 cofactor and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing. [GOC:lnp, PMID:11773622]"}
{"concept_id": "C5672797", "aliases": ["nuclear envelope periphery of the nuclear pore complex", "nuclear envelope adjacent to nuclear pore complex location", "nuclear envelope periphery of the nuclear pore complex location", "nuclear envelope adjacent to NPC"], "types": ["T026"], "canonical_name": "nuclear envelope adjacent to nuclear pore complex", "definition": "The region of the nuclear envelope situated in close proximity to a nuclear pore complex. [GOC:mah, PMID:21802294, PMID:24184107]"}
{"concept_id": "C5672798", "aliases": ["rixosome complex location"], "types": ["T026"], "canonical_name": "rixosome complex", "definition": "A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans. [GOC:vw, PMID:32491985, PMID:35355014]"}
{"concept_id": "C5672799", "aliases": ["dihydropyrimidine dehydrogenase (NAD+) complex location"], "types": ["T026"], "canonical_name": "dihydropyrimidine dehydrogenase (NAD+) complex", "definition": "A heteromultimeric complex capable of dihydropyrimidine dehydrogenase (NAD+); in E. coli, composed of PreA and PreT. [PMID:21169495, PMID:34097066]"}
{"concept_id": "C5672800", "aliases": ["large ribosomal subunit pre-assembly complex location"], "types": ["T026"], "canonical_name": "large ribosomal subunit pre-assembly complex", "definition": "A protein complex that assists early maturation of nascent 60S ribosomal subunits. The complex interacts with the large ribosomal subunit rRNA via one of the components (Urb2 in S. cerevisiae) and requires a RNA helicase (Dbp6 in S. cerevisiae). [GOC:lnp, PMID:17145778, PMID:9528757]"}
{"concept_id": "C5672801", "aliases": ["serine-tRNA ligase complex location"], "types": ["T026"], "canonical_name": "serine-tRNA ligase complex", "definition": "A heterodimeric enzyme complex that catalyzes the ligation of serine to tRNA(Ser), forming L-seryl-tRNA(Ser). [PMID:30943413]"}
{"concept_id": "C5672802", "aliases": ["NLRP6 inflammasome complex location"], "types": ["T026"], "canonical_name": "NLRP6 inflammasome complex", "definition": "An inflammasome complex that consists of NLRP6, PYCARD/ASC and caspase-1 or caspase-4/caspase-11. [PMID:30674671, PMID:34678144]"}
{"concept_id": "C5672803", "aliases": ["PAT complex location"], "types": ["T026"], "canonical_name": "PAT complex", "definition": "A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the correct folding of multipass membrane proteins in the ER membrane. In human, the substrate-binding Asterix (PAT10, WDR83OS) forms an obligate heterodimer with CCDC47. [PMID:32814900, PMID:33082068, PMID:33960686]"}
{"concept_id": "C5672807", "aliases": ["H3-H4 histone carrier activity"], "types": ["T044"], "canonical_name": "H3-H4 histone complex chaperone activity", "definition": "A histone chaperone that carries a H3-H4 histone complex. [PMID:28053344]"}
{"concept_id": "C5672808", "aliases": ["H2A-H2B histone carrier activity"], "types": ["T044"], "canonical_name": "H2A-H2B histone complex chaperone activity", "definition": "A histone chaperone that carries a H2A-H2B histone complex. [PMID:28053344]"}
{"concept_id": "C5672809", "aliases": [], "types": ["T045"], "canonical_name": "lncRNA-mediated gene silencing", "definition": "A post-transcriptional gene silencing pathway in which regulatory long noncoding RNAs (lncRNAs) elicit silencing of specific target genes, often miRNAs. [PMID:34454184]"}
{"concept_id": "C5672810", "aliases": [], "types": ["T044"], "canonical_name": "actin severing activator activity", "definition": "Binds to and increases the activity of a actin severing protein. [PMID:25451933]"}
{"concept_id": "C5672811", "aliases": [], "types": ["T044"], "canonical_name": "3-sulfino-L-alanine: proton, glutamate antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H(+)(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out). [PMID:11566871]"}
{"concept_id": "C5672812", "aliases": [], "types": ["T044"], "canonical_name": "aspartate:glutamate, proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L-aspartate(out) + L-glutamate(in). [PMID:11566871]"}
{"concept_id": "C5672813", "aliases": [], "types": ["T042"], "canonical_name": "lens placode formation", "definition": "The initial developmental process that will lead to the formation of an eye. [GOC:dph]"}
{"concept_id": "C5672814", "aliases": [], "types": ["T044"], "canonical_name": "nuclear steroid receptor activity", "definition": "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019]"}
{"concept_id": "C5672815", "aliases": [], "types": ["T044"], "canonical_name": "cytoskeletal motor activity", "definition": "Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]"}
{"concept_id": "C5672816", "aliases": [], "types": ["T044"], "canonical_name": "calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity", "definition": "Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin. [PMID:8557689, PMID:9419816]"}
{"concept_id": "C5672817", "aliases": [], "types": ["T044"], "canonical_name": "dihydropyrimidine dehydrogenase (NAD+) activity", "definition": "Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+. [PMID:23150645]"}
{"concept_id": "C5672818", "aliases": [], "types": ["T044"], "canonical_name": "nuclear glucocorticoid receptor activity", "definition": "Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function. [GOC:signaling, PMID:17689856, PMID:20920967]"}
{"concept_id": "C5672819", "aliases": [], "types": ["T044"], "canonical_name": "high-affinity L-glutamate transmembrane transporter activity", "definition": "Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [TC:2.A.3.10.5]"}
{"concept_id": "C5672820", "aliases": [], "types": ["T045"], "canonical_name": "DNA replication-dependent chromatin assembly", "definition": "The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. [GOC:mah]"}
{"concept_id": "C5672821", "aliases": [], "types": ["T044"], "canonical_name": "3-demethoxyubiquinol 3-hydroxylase activity", "definition": "Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O. [RHEA:50908]"}
{"concept_id": "C5672822", "aliases": [], "types": ["T044"], "canonical_name": "ribosomal protein S5-alanine N-acetyltransferase activity", "definition": "Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[ribosomal protein] = CoA + H+ + N-terminal N-alpha-acetyl-L-alanyl-[ribosomal protein]. [RHEA:43752]"}
{"concept_id": "C5672823", "aliases": [], "types": ["T043"], "canonical_name": "auxin export across the plasma membrane", "definition": "The directed movement of auxins from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:tair_curators, PMID:16990790]"}
{"concept_id": "C5672824", "aliases": ["siRNA-mediated long-distance posttranscriptional gene silencing"], "types": ["T045"], "canonical_name": "siRNA-mediated long-distance post-transcriptional gene silencing", "definition": "An siRNA-mediated posttranscriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs, and in which the silencing signal originates in one tissue and occurs in a different tissue. [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412]"}
{"concept_id": "C5672825", "aliases": [], "types": ["T043"], "canonical_name": "nitrate transmembrane transport", "definition": "The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]"}
{"concept_id": "C5672826", "aliases": [], "types": ["T044"], "canonical_name": "hexuronide transmembrane transport", "definition": "The directed movement of hexuronide across a membrane. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate. [GOC:ai]"}
{"concept_id": "C5672827", "aliases": [], "types": ["T043"], "canonical_name": "glycerol transmembrane transport", "definition": "The directed movement of glycerol across a membrane. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. [GOC:ai]"}
{"concept_id": "C5672828", "aliases": [], "types": ["T043"], "canonical_name": "galactitol transmembrane transport", "definition": "The directed movement of galactitol across a membrane. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. [GOC:ai]"}
{"concept_id": "C5672829", "aliases": [], "types": ["T043"], "canonical_name": "mannitol transmembrane transport", "definition": "The directed movement of mannitol across a membrane. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group. [GOC:ai]"}
{"concept_id": "C5672830", "aliases": [], "types": ["T043"], "canonical_name": "pyramidal neuron migration to cerebral cortex", "definition": "The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695, PMID:22192824]"}
{"concept_id": "C5672831", "aliases": [], "types": ["T044"], "canonical_name": "nuclear estrogen receptor activity", "definition": "Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function. [GOC:signaling, PMID:17615392]"}
{"concept_id": "C5672832", "aliases": [], "types": ["T044"], "canonical_name": "nuclear estrogen receptor binding", "definition": "Binding to a nuclear estrogen receptor. [GOC:ai]"}
{"concept_id": "C5672833", "aliases": [], "types": ["T045"], "canonical_name": "programmed DNA elimination by chromosome breakage", "definition": "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage. [GOC:ns, PMID:15956677, PMID:25303953, PMID:32165395]"}
{"concept_id": "C5672834", "aliases": [], "types": ["T044"], "canonical_name": "nuclear cortisol receptor binding", "definition": "Binding to a nuclear cortisol receptor. [GOC:mah, PMID:12511169]"}
{"concept_id": "C5672835", "aliases": [], "types": ["T044"], "canonical_name": "nuclear mineralocorticoid receptor binding", "definition": "Binding to a nuclear mineralocorticoid receptor. [GOC:mah, PMID:12511169]"}
{"concept_id": "C5672836", "aliases": [], "types": ["T044"], "canonical_name": "nuclear cortisol receptor activity", "definition": "Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function. [GOC:mah, PMID:12511169]"}
{"concept_id": "C5672837", "aliases": [], "types": ["T044"], "canonical_name": "nuclear progesterone receptor binding", "definition": "Binding to a nuclear progesterone receptor. [GOC:mah]"}
{"concept_id": "C5672838", "aliases": ["regulation of extent of heterochromatin formation"], "types": ["T045"], "canonical_name": "heterochromatin boundary formation", "definition": "A process that forms a boundary that limits the spreading of heterochromatin along a chromosome. [GOC:mah]"}
{"concept_id": "C5672839", "aliases": [], "types": ["T044"], "canonical_name": "3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity", "definition": "Catalysis of the reactions: a 3alpha-hydroxy bile acid CoA + NAD+ = a 3-oxo bile acid CoA + H+ + NADH. [PMID:23836456, RHEA:55380]"}
{"concept_id": "C5672840", "aliases": [], "types": ["T044"], "canonical_name": "bile-acid-CoA transferase activity", "definition": "Catalysis of the reaction: deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA. [PMID:22021638, RHEA:49436]"}
{"concept_id": "C5672841", "aliases": [], "types": ["T044"], "canonical_name": "nuclear glucocorticoid receptor binding", "definition": "Binding to a nuclear glucocorticoid receptor. [GOC:bf]"}
{"concept_id": "C5672842", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity", "definition": "Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses. [PMID:17438296, PMID:22674996]"}
{"concept_id": "C5672843", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity", "definition": "Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. [PMID:21632562]"}
{"concept_id": "C5672844", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity", "definition": "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. [PMID:19019954, PMID:33727702]"}
{"concept_id": "C5672845", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity", "definition": "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. [PMID:11943871, PMID:16014964, PMID:19557165]"}
{"concept_id": "C5672846", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1). [PMID:32699158]"}
{"concept_id": "C5672847", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2). [PMID:32699158]"}
{"concept_id": "C5672848", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host ISG15-protein conjugation", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 conjugation to a susbtrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives. [PMID:11157743, PMID:18604270]"}
{"concept_id": "C5672849", "aliases": [], "types": ["T046"], "canonical_name": "suppression by virus of host PKR signaling", "definition": "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response. [PMID:15207627]"}
{"concept_id": "C5672850", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity", "definition": "Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1. [PMID:22171259, PMID:34084167]"}
{"concept_id": "C5672851", "aliases": [], "types": ["T038"], "canonical_name": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity", "definition": "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E). [PMID:19153231, PMID:22532683, PMID:24173023]"}
{"concept_id": "C5672852", "aliases": ["small RNA-mediated gene silencing"], "types": ["T045"], "canonical_name": "sRNA-mediated gene silencing", "definition": "A post-transcriptional gene silencing pathway mediated by the action of small regulatory non-coding RNAs (sRNAs). sRNAs are 20-500 nucleotides in length and found in bacteria. [PMID:12460531, PMID:2468565, PMID:33963446]"}
{"concept_id": "C5672853", "aliases": [], "types": ["T043"], "canonical_name": "maltodextrin transmembrane transport", "definition": "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane. [GOC:jl]"}
{"concept_id": "C5672854", "aliases": [], "types": ["T044"], "canonical_name": "transmembrane transporter binding", "definition": "Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]"}
{"concept_id": "C5672855", "aliases": [], "types": ["T043"], "canonical_name": "xenobiotic export from cell", "definition": "The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]"}
{"concept_id": "C5672856", "aliases": [], "types": ["T044"], "canonical_name": "nuclear thyroid hormone receptor binding", "definition": "Binding to a nuclear thyroid hormone receptor. [GOC:ai]"}
{"concept_id": "C5672857", "aliases": [], "types": ["T043"], "canonical_name": "glucosylglycerol transmembrane transport", "definition": "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, across a membrane. [GOC:ai]"}
{"concept_id": "C5672858", "aliases": [], "types": ["T044"], "canonical_name": "phosphoenolpyruvate-dependent mannosylglycerate phosphotransferase system", "definition": "A phosphoenolpyruvate-dependent sugar phosphotransferase transport specific for mammosylglycerate. [PMID:368051]"}
{"concept_id": "C5672859", "aliases": [], "types": ["T040"], "canonical_name": "disruption by symbiont of host cytoskeleton", "definition": "The process in which an organism effects a change that impairs the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]"}
{"concept_id": "C5672860", "aliases": [], "types": ["T045"], "canonical_name": "inactivation of paternal X chromosome by genomic imprinting", "definition": "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genomic imprinting. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C5672861", "aliases": [], "types": ["T045"], "canonical_name": "inactivation of X chromosome by genomic imprinting", "definition": "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genomic imprinting. [GOC:dph, GOC:sdb_2009, GOC:tb]"}
{"concept_id": "C5672862", "aliases": [], "types": ["T043"], "canonical_name": "auxin import into cell", "definition": "The directed movement of auxins from outside of a cell into a cell. [PMID:22773749]"}
{"concept_id": "C5672863", "aliases": ["2',3' cyclic GMP-AMP synthase activity", "2',3' cyclic-GMP-AMP synthase activity", "cyclic 2',3' GAMP synthase activity"], "types": ["T044"], "canonical_name": "2',3'-cyclic GMP-AMP synthase activity", "definition": "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5') (cyclic 2',3' GAMP). [GOC:dph, PMID:23258413, RHEA:42064]"}
{"concept_id": "C5672864", "aliases": ["2',3' cyclic GAMP binding", "2',3'-cyclic GAMP binding", "c[G(2',5')pA(3',5')p] binding", "2',3' cGAMP binding", "2',5-3',5'-cyclic GMP-AMP binding", "2',3'-cGAMP binding"], "types": ["T044"], "canonical_name": "2',3'-cyclic GMP-AMP binding", "definition": "Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages. [GOC:dph, PMID:23258412, PMID:23910378]"}
{"concept_id": "C5672865", "aliases": [], "types": ["T043"], "canonical_name": "actin polymerization-dependent cell migration in host", "definition": "The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of actin at one pole of the symbiont cell. Some bacteria use host actin for migration. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:jl, GOC:mah, PMID:15773977]"}
{"concept_id": "C5672866", "aliases": [], "types": ["T044"], "canonical_name": "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity", "definition": "Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. [GOC:mah, GOC:pde]"}
{"concept_id": "C5672867", "aliases": [], "types": ["T045"], "canonical_name": "RISC complex assembly", "definition": "The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA. [PMID:14512631, PMID:14744438, PMID:19239886, PMID:22233755, PMID:27184117]"}
{"concept_id": "C5672868", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-tri/di-methyl-lysine-27 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [GOC:sp, PMID:20622853]"}
{"concept_id": "C5672869", "aliases": [], "types": ["T043"], "canonical_name": "endoplasmic reticulum to cytosol auxin transport", "definition": "The directed movement of auxins from endoplasmic reticulum to cytosol. [PMID:19506555]"}
{"concept_id": "C5672870", "aliases": [], "types": ["T044"], "canonical_name": "toxin sequestering activity", "definition": "Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [GOC:rs, PMID:19143615, PMID:19325885, PMID:21819231, PMID:22545240, PMID:24806488, Wikipedia:Toxin-antitoxin_system#Type_II]"}
{"concept_id": "C5672871", "aliases": [], "types": ["T045"], "canonical_name": "global gene silencing by mRNA cleavage", "definition": "A posttranscriptional gene silencing pathway that involves the cleavage of mRNAs in a non-gene-specific manner. [PMID:15009896]"}
{"concept_id": "C5672872", "aliases": [], "types": ["T044"], "canonical_name": "ATP:farnesol kinase activity", "definition": "Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+. [GOC:pz, RHEA:61656]"}
{"concept_id": "C5672873", "aliases": [], "types": ["T044"], "canonical_name": "8-oxo-(d)RTP hydrolase activity", "definition": "Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+. [PMID:11139615]"}
{"concept_id": "C5672874", "aliases": [], "types": ["T044"], "canonical_name": "purine ribonucleotide salvage", "definition": "Any process which produces a purine ribonucleotide from derivatives of it, without de novo synthesis. [PMID:8864750]"}
{"concept_id": "C5672875", "aliases": [], "types": ["T044"], "canonical_name": "purine deoxyribonucleotide salvage", "definition": "Any process which produces a purine deoxyribonucleotide from derivatives of it, without de novo synthesis. [PMID:6605343]"}
{"concept_id": "C5672876", "aliases": [], "types": ["T044"], "canonical_name": "dAMP salvage", "definition": "Any process which produces a dAMP from derivatives of it, without de novo synthesis. [PMID:21829339, PMID:6605343]"}
{"concept_id": "C5672877", "aliases": [], "types": ["T044"], "canonical_name": "dGMP salvage", "definition": "Any process which produces a dGMP from derivatives of it, without de novo synthesis. [PMID:21829339, PMID:6605343]"}
{"concept_id": "C5672878", "aliases": [], "types": ["T044"], "canonical_name": "dIMP salvage", "definition": "Any process which produces a dIMP from derivatives of it, without de novo synthesis. [PMID:8692979]"}
{"concept_id": "C5672879", "aliases": [], "types": ["T044"], "canonical_name": "(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity", "definition": "Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. [PMID:19571038, PMID:25203508]"}
{"concept_id": "C5672880", "aliases": ["'de novo' guanosine 5'-monophosphate biosynthetic process"], "types": ["T044"], "canonical_name": "'de novo' GMP biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of guanosine 5'-monophosphate (GMP) through an inosine 5'-monophosphate (IMP) intermediate. [PMID:25605736]"}
{"concept_id": "C5672881", "aliases": [], "types": ["T044"], "canonical_name": "18S rRNA aminocarboxypropyltransferase activity", "definition": "Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine. [PMID:27084949]"}
{"concept_id": "C5672882", "aliases": [], "types": ["T044"], "canonical_name": "ecdysteroid 22-kinase activity", "definition": "Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+. [PMID:16899460, RHEA:67972]"}
{"concept_id": "C5672883", "aliases": [], "types": ["T043"], "canonical_name": "regulation of palmitic acid catabolic process", "definition": "Any process that modulates the frequency, rate or extent of a palmitic acid catabolic process. [PMID:14677856]"}
{"concept_id": "C5672884", "aliases": [], "types": ["T044"], "canonical_name": "negative regulation of palmitic acid catabolic process", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of a palmitic acid catabolic process. [PMID:14677856]"}
{"concept_id": "C5672885", "aliases": [], "types": ["T044"], "canonical_name": "positive regulation of palmitic acid catabolic process", "definition": "Any process that activates or increases the frequency, rate or extent of a palmitic acid catabolic process. [PMID:14677856]"}
{"concept_id": "C5672886", "aliases": [], "types": ["T043"], "canonical_name": "regulation of R7 cell fate commitment", "definition": "Any process that modulates the frequency, rate or extent of R7 cell fate commitment. [GOC:ha, PMID:22878552]"}
{"concept_id": "C5672887", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of R7 cell fate commitment", "definition": "Any process that activates or increases the frequency, rate or extent of R7 cell fate commitment. [GOC:ha, PMID:22878552]"}
{"concept_id": "C5672888", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of R7 cell fate commitment", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of R7 cell fate commitment. [GOC:ha, PMID:22878552]"}
{"concept_id": "C5672889", "aliases": [], "types": ["T044"], "canonical_name": "acyl-coenzyme A diphosphatase activity", "definition": "Catalysis of the reaction: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+). [PMID:32915949, RHEA:50044]"}
{"concept_id": "C5672890", "aliases": [], "types": ["T045"], "canonical_name": "double-strand break repair via transcription-associated homologous recombination", "definition": "A mechanism of homologous recombination and DNA repair in which transcript RNA is used as a template for DSB repair. [PMID:25186730]"}
{"concept_id": "C5672891", "aliases": [], "types": ["T044"], "canonical_name": "Lewis x epitope biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of a Lewis x epitope, a trisaccharide (beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosamine) expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system. The related Lewis x epitope is formed by alpha(1,3) fucosylation of the N-acetylglucosaminyl residue of a type 2 histo-blood group antigen precursor disaccharide. [PMID:16973732, PMID:23000574]"}
{"concept_id": "C5672892", "aliases": [], "types": ["T044"], "canonical_name": "isoprenoid diphosphate phosphatase activity", "definition": "Catalysis of the dephosphorylation of isoprenoid diphosphates. [PMID:33246356]"}
{"concept_id": "C5672893", "aliases": [], "types": ["T044"], "canonical_name": "Glc2Man9GlcNAc2 oligosaccharide glucosidase activity", "definition": "Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)-[protein] + H(2)O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose. [PMID:30389790]"}
{"concept_id": "C5672894", "aliases": ["cyclic-di-AMP synthase"], "types": ["T044"], "canonical_name": "diadenylate cyclase activity", "definition": "Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate. [PMID:30884174, RHEA:35655]"}
{"concept_id": "C5672895", "aliases": [], "types": ["T044"], "canonical_name": "cyclic-di-AMP phosphodiesterase activity", "definition": "Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+. [PMID:21909268, RHEA:54420]"}
{"concept_id": "C5672896", "aliases": [], "types": ["T045"], "canonical_name": "box C/D RNA 5'-end processing", "definition": "Any process involved in forming the mature 5' end of a box C/D RNA molecule. [PMID:34352089]"}
{"concept_id": "C5672897", "aliases": [], "types": ["T044"], "canonical_name": "XMP 5'-nucleosidase activity", "definition": "Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine. [PMID:34824243, RHEA:28530]"}
{"concept_id": "C5672898", "aliases": [], "types": ["T044"], "canonical_name": "dihydrouridine synthase activity", "definition": "Catalysis of the reaction: RNA-uracil + acceptor = RNA-dihydrouridine + reduced acceptor. [PMID:12581659, PMID:25073379]"}
{"concept_id": "C5672899", "aliases": [], "types": ["T044"], "canonical_name": "mRNA dihydrouridine synthase activity", "definition": "Catalysis of the reaction: mRNA-uracil + acceptor = mRNA-dihydrouridine + reduced acceptor. [PMID:34798057]"}
{"concept_id": "C5672900", "aliases": [], "types": ["T044"], "canonical_name": "muramoyltetrapeptide carboxypeptidase activity", "definition": "GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H(2)O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine. [PMID:10428950, PMID:15361936]"}
{"concept_id": "C5672901", "aliases": [], "types": ["T044"], "canonical_name": "dopaminechrome tautomerase activity", "definition": "Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole. [PMID:34388859]"}
{"concept_id": "C5672902", "aliases": [], "types": ["T044"], "canonical_name": "UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity", "definition": "Catalysis of the reaction: ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate. [PMID:17384195, PMID:8808921, RHEA:29563]"}
{"concept_id": "C5672903", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent protein lipoamidase activity", "definition": "Catalysis of the reaction: (R)-N6-lipoyl-L-lysyl-[protein] + H2O + NAD+ = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. [PMID:25525879]"}
{"concept_id": "C5672904", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent protein biotinidase activity", "definition": "Catalysis of the reaction: H2O + N6-biotinyl-L-lysyl-[protein] + NAD+ = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. [PMID:25525879]"}
{"concept_id": "C5672905", "aliases": [], "types": ["T044"], "canonical_name": "L-glutamate:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out). [PMID:29273736]"}
{"concept_id": "C5672906", "aliases": [], "types": ["T044"], "canonical_name": "carotenoid isomerooxygenase activity", "definition": "Catalysis of the reaction: Zeaxanthin + O(2) <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal. [PMID:19020100, PMID:19889630, RHEA:33931]"}
{"concept_id": "C5672907", "aliases": [], "types": ["T044"], "canonical_name": "glucagon family peptide binding", "definition": "Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP). [PMID:17715056]"}
{"concept_id": "C5672908", "aliases": [], "types": ["T054"], "canonical_name": "olfactory sociosexual communication", "definition": "The use of external chemical cues called pheromones to send social and sexual information between members of the same species, leading to specific behavioral responses. Pheromones may be detected by two olfactory sensory circuits, the main olfactory pathway and the vomeronasal system. [GOC:krc, PMID:17935991]"}
{"concept_id": "C5672909", "aliases": [], "types": ["T044"], "canonical_name": "long-chain fatty acid omega-1 hydroxylase activity", "definition": "Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. [GOC:nhn, PMID:18577768, PMID:22772592, PMID:24242247, RHEA:60936]"}
{"concept_id": "C5672910", "aliases": [], "types": ["T043"], "canonical_name": "lateral pseudopodium retraction", "definition": "The myosin-based contraction and retraction of a lateral pseudopodium. [GOC:krc, GOC:pf, PMID:12953059, PMID:15483055, PMID:17623773]"}
{"concept_id": "C5672911", "aliases": [], "types": ["T044"], "canonical_name": "lipid modification by small protein conjugation", "definition": "A lipid modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target lipid. [GOC:sp, PMID:34012115]"}
{"concept_id": "C5672912", "aliases": [], "types": ["T044"], "canonical_name": "lipid ubiquitination", "definition": "The process in which one or more ubiquitin groups are added to a lipid. [GOC:sp, PMID:34012115]"}
{"concept_id": "C5672913", "aliases": [], "types": ["T040"], "canonical_name": "procyclogenesis", "definition": "The morphological, biochemical and genetic changes that induce the differentiation of bloodstream form trypomastigotes into procyclic trypomastigotes in some of the Trypanosomatidae species such as Trypanosoma brucei. This process occurs inside the midgut of the tsetse fly vectors in T. brucei. [GOC:ach, https://www.cdc.gov/parasites/sleepingsickness/biology.html, PMID:10593184, PMID:1698624, PMID:17997129, PMID:3194362, PMID:3194363]"}
{"concept_id": "C5672914", "aliases": [], "types": ["T044"], "canonical_name": "NuRD complex binding", "definition": "Binding to a NuRD complex. [GOC:krc, GOC:lb, PMID:25150861]"}
{"concept_id": "C5672915", "aliases": ["appressorium-mediated host penetration", "appressorium-mediated invasion into host", "appressorium-mediated penetration into host", "appressorium-mediated host invasion"], "types": ["T040"], "canonical_name": "appressorium-mediated entry into host", "definition": "Penetration by a symbiont into a host organism via an appressorium. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:ach, GOC:krc, PMID:14731267, PMID:22589729]"}
{"concept_id": "C5672916", "aliases": [], "types": ["T045"], "canonical_name": "ATP-dependent DNA (cytosine-5-)-methyltransferase activity", "definition": "Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis. [GOC:krc, PMID:31955845, PMID:32437639]"}
{"concept_id": "C5672917", "aliases": ["protein localisation to centriolar satellite"], "types": ["T043"], "canonical_name": "protein localization to centriolar satellite", "definition": "A process in which a protein is transported to, or maintained in, a location within a centriolar satellite. [PMID:34782749]"}
{"concept_id": "C5672918", "aliases": [], "types": ["T043"], "canonical_name": "contractile vacuole localization", "definition": "The directed movement of the contractile vacuole to a specific location. [PMID:19687255]"}
{"concept_id": "C5672919", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent protein disaggregase activity", "definition": "An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates. [PMID:26312418]"}
{"concept_id": "C5672920", "aliases": ["histone reader"], "types": ["T044"], "canonical_name": "histone reader activity", "definition": "A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. [PMID:11498575, PMID:25688442, PMID:31082667, PMID:32260176, PMID:34726351]"}
{"concept_id": "C5672921", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of pyroptosis", "definition": "Any process that increases the frequency, rate or extent of pyroptosis. [PMID:24626226]"}
{"concept_id": "C5672922", "aliases": [], "types": ["T044"], "canonical_name": "catalytic activity, acting on a nucleic acid", "definition": "Catalytic activity that acts to modify a nucleic acid. [GOC:pg]"}
{"concept_id": "C5672923", "aliases": ["metaphase spindle stability", "metaphase spindle stabilization"], "types": ["T043"], "canonical_name": "mitotic spindle formation (spindle phase two)", "definition": "The spindle organization process in which the spindle is maintained at a constant length during mitotic metaphase. [PMID:32723864]"}
{"concept_id": "C5672924", "aliases": [], "types": ["T043"], "canonical_name": "meiotic spindle formation (spindle phase two)", "definition": "The spindle organization process in which the spindle is maintained at a constant length during meiotic metaphase. [PMID:32723864]"}
{"concept_id": "C5672925", "aliases": [], "types": ["T044"], "canonical_name": "hydroxymethylglutaryl-CoA reductase (NADH) activity", "definition": "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) <=> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH. [PMID:29224355, RHEA:14833]"}
{"concept_id": "C5672926", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of pre-B cell receptor expression", "definition": "Any process that stops, prevents or reduces the frequency, rate or extent of the process leading up to expression of the pre-B cell receptor on the surface of pre-B cells. [PMID:22949502]"}
{"concept_id": "C5672927", "aliases": [], "types": ["T044"], "canonical_name": "P450-containing electron transport chain", "definition": "A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways. [PMID:16042601]"}
{"concept_id": "C5672928", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of cell cycle switching, mitotic to meiotic cell cycle", "definition": "Any process that activates or increases the frequency, rate or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division. [PMID:22375066]"}
{"concept_id": "C5672929", "aliases": ["invasive hyphae formation"], "types": ["T040"], "canonical_name": "cell-to-cell migration by invasive hypha", "definition": "The directional movement of a hyphal filament from one host cell to another. This process involves the clearance of plant-derived plasmodesmal occlusion materials, cytoskeleton based constriction of invasive hypha to traverse plasmodesmata. Septins and F-actin are reorganized into an hourglass shape at the point of maximum hyphal constriction. [PMID:29567712]"}
{"concept_id": "C5672930", "aliases": ["radial glia-dependent neuronal migration"], "types": ["T043"], "canonical_name": "radial glia-guided pyramidal neuron migration", "definition": "The radial migration of a pyramidal neuron along radial glial cells. [PMID:3760547]"}
{"concept_id": "C5672931", "aliases": [], "types": ["T044"], "canonical_name": "futile creatine cycle", "definition": "The phosphorylation and dephosphorylation of creatine in a futile cycle, which dissipates the high energy charge of phosphocreatine as heat without performing any mechanical or chemical work. The futile creatine cycle takes place in thermogenic fat cells and is part of adaptive thermogenesis. [PMID:33597756, PMID:33981039]"}
{"concept_id": "C5672932", "aliases": ["pyripyropene A formation", "pyripyropene A biosynthesis", "pyripyropene A synthesis", "pyripyropene A anabolism"], "types": ["T044"], "canonical_name": "pyripyropene A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of pyripyropene A. [GOC:ach, PMID:21224862, PMID:26019565]"}
{"concept_id": "C5672933", "aliases": ["fumitremorgin C formation", "fumitremorgin C biosynthesis", "fumitremorgin C synthesis", "fumitremorgin C anabolism"], "types": ["T044"], "canonical_name": "fumitremorgin C biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of fumitremorgin C. [GOC:ach, PMID:19226505]"}
{"concept_id": "C5672934", "aliases": ["tryprostatin A synthesis", "tryprostatin A biosynthesis", "tryprostatin A formation", "tryprostatin A anabolism"], "types": ["T044"], "canonical_name": "tryprostatin A biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of tryprostatin A. [GOC:ach, PMID:19226505]"}
{"concept_id": "C5672935", "aliases": [], "types": ["T044"], "canonical_name": "endodeoxyribonuclease activator activity", "definition": "Binds to and increases the activity of an endodeoxyribonuclease. [PMID:33836577]"}
{"concept_id": "C5672936", "aliases": ["ATPase activity", "ATPase activity, coupled", "ATP hydrolysis-dependent activity", "ATPase-dependent activity"], "types": ["T044"], "canonical_name": "ATP-dependent activity", "definition": "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient. [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]"}
{"concept_id": "C5672937", "aliases": ["ATP hydrolysis-dependent chromatin remodeler activity", "ATPase-dependent chromatin remodeler activity"], "types": ["T045"], "canonical_name": "ATP-dependent chromatin remodeler activity", "definition": "An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]"}
{"concept_id": "C5672938", "aliases": [], "types": ["T044"], "canonical_name": "cytoskeletal motor regulator activity", "definition": "Binds to and modulates the activity of a motor protein. [PMID:23142046, PMID:33221250]"}
{"concept_id": "C5672939", "aliases": [], "types": ["T044"], "canonical_name": "cytoskeletal motor activator activity", "definition": "Binds to and increases the activity of a motor protein. [PMID:33221250]"}
{"concept_id": "C5672940", "aliases": [], "types": ["T044"], "canonical_name": "cytoskeletal motor inhibitor activity", "definition": "Binds to and stops, prevents, or reduces the activity of a motor protein. [PMID:23142046]"}
{"concept_id": "C5672941", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent protein folding chaperone", "definition": "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. [PMID:27365453]"}
{"concept_id": "C5672942", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent FeS chaperone activity", "definition": "Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis. [PMID:16843540]"}
{"concept_id": "C5672943", "aliases": ["ATP-dependent DNA damage sensing activity"], "types": ["T044"], "canonical_name": "ATP-dependent DNA damage sensor activity", "definition": "A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. [PMID:33302090, PMID:33510387]"}
{"concept_id": "C5672944", "aliases": ["histone H3-H4 dimer loading activity", "H3-H4 dimer loading activity"], "types": ["T044"], "canonical_name": "ATP-dependent H3-H4 histone complex chaperone activity", "definition": "A histone chaperone that carries a H3-H4 histone complex, driven by ATP hydrolysis. [PMID:31848341, PMID:33658433]"}
{"concept_id": "C5672945", "aliases": [], "types": ["T045"], "canonical_name": "annealing activity", "definition": "An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule. [PMID:22888405]"}
{"concept_id": "C5672946", "aliases": [], "types": ["T043"], "canonical_name": "regulation of oxytocin production", "definition": "Any process that modulates the frequency, rate, or extent of production of oxytocin. [PMID:25096581]"}
{"concept_id": "C5672947", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of oxytocin production", "definition": "Any process that activates or increases the frequency, rate or extent of production of oxytocin. [PMID:25096581]"}
{"concept_id": "C5672948", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of oxytocin production", "definition": "Any process that stops, prevents, or reduces the rate of production of oxytocin. [PMID:25096581]"}
{"concept_id": "C5672949", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent cohesin unloading activity", "definition": "Facilitating a conformational change to unload a cohesin complex from sister chromatids, driven by ATP hydrolysis. [PMID:26687354]"}
{"concept_id": "C5672950", "aliases": ["euchromatin maintenance during transcription elongation", "maintenance of transcriptionally active chromatin during transcription elongation", "maintainance of chromatin integrity during transcription elongation by RNAPII"], "types": ["T045"], "canonical_name": "co-transcriptional chromatin reassembly", "definition": "The reestablishment of chromatin structure that was disrupted upon passage of RNA polymerase II during transcription elongation. This process prevents cryptic intragenic transcription initiation. [PMID:22922743]"}
{"concept_id": "C5672951", "aliases": [], "types": ["T044"], "canonical_name": "ATP-dependent histone chaperone activity", "definition": "Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome, driven by ATP hydrolysis. [PMID:26459557]"}
{"concept_id": "C5672952", "aliases": ["cAMP relay"], "types": ["T043"], "canonical_name": "oscillatory cAMP signaling", "definition": "Fluctuation in the extracellular cAMP levels due to the alternate activation of adenylate cyclase, which produces cAMP, and phosphodiesterase, which degrades it. Occurs in Dictyostelium during early sorocarp development. Oscillation in signaling result is directional chemotaxis of cells towards the center of the aggregate. [PMID:18657484]"}
{"concept_id": "C5672953", "aliases": [], "types": ["T044"], "canonical_name": "molecular function activator activity", "definition": "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators]"}
{"concept_id": "C5672954", "aliases": [], "types": ["T044"], "canonical_name": "molecular function inhibitor activity", "definition": "A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators]"}
{"concept_id": "C5672955", "aliases": [], "types": ["T044"], "canonical_name": "ABC-type sodium transporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) -> ADP + phosphate + Na(out). [PMID:9106203]"}
{"concept_id": "C5672956", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-di/monomethyl-lysine-36 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:20531378]"}
{"concept_id": "C5672957", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-tri/dimethyl-lysine-36 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:21914792]"}
{"concept_id": "C5672958", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity", "definition": "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. [PMID:22473470]"}
{"concept_id": "C5672959", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-di/monomethyl-lysine-9 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:16603238]"}
{"concept_id": "C5672960", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-tri/dimethyl-lysine-9 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:20208542, PMID:20531378]"}
{"concept_id": "C5672961", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-di/monomethyl-lysine-9 FAD-dependent demethylase activity", "definition": "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. [PMID:22473470]"}
{"concept_id": "C5672962", "aliases": [], "types": ["T044"], "canonical_name": "RNA folding chaperone", "definition": "Binding to an RNA or an RNA-containing complex to assist the folding process. [PMID:31165735]"}
{"concept_id": "C5672963", "aliases": [], "types": ["T044"], "canonical_name": "very long-chain fatty acid omega-hydroxylase activity", "definition": "Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [PMID:16547005]"}
{"concept_id": "C5672964", "aliases": [], "types": ["T044"], "canonical_name": "molecular condensate scaffold activity", "definition": "Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. [PMID:28225081]"}
{"concept_id": "C5672965", "aliases": ["non-membrane-enclosed organelle assembly", "non-membrane-enclosed organelle formation", "non-membrane-bounded organelle formation"], "types": ["T043"], "canonical_name": "non-membrane-bounded organelle assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle. [PMID:28225081]"}
{"concept_id": "C5672966", "aliases": ["L-2-hydroxyglutarate dehydrogenase activity"], "types": ["T044"], "canonical_name": "(S)-2-hydroxyglutarate dehydrogenase activity", "definition": "Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol. [PMID:30498244, RHEA:58664]"}
{"concept_id": "C5672967", "aliases": [], "types": ["T045"], "canonical_name": "attachment of telomeric heterochromatin to nuclear envelope", "definition": "The process in which physical connections are formed between sub-telomeric heterochromatin and the nuclear envelope facilitating bouquet formation. [PMID:31635174]"}
{"concept_id": "C5672968", "aliases": ["3',2'-cyclic GAMP synthase activity", "3',2' cyclic-GMP-AMP synthase activity"], "types": ["T044"], "canonical_name": "3',2'-cyclic GMP-AMP synthase activity", "definition": "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP). [PMID:34261127]"}
{"concept_id": "C5672969", "aliases": ["3',3' cyclic-GAMP synthase activity", "3',3' cyclic-GMP-AMP synthase activity", "3',3'-cyclic GAMP synthase activity"], "types": ["T044"], "canonical_name": "3',3'-cyclic GMP-AMP synthase activity", "definition": "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP). [PMID:30787435, RHEA:35647]"}
{"concept_id": "C5672970", "aliases": ["3',3'-cGMP-AMP binding", "3',3'-cyclic GAMP binding", "3',3' cyclic-GMP-AMP binding", "3',3'-cGAMP binding"], "types": ["T044"], "canonical_name": "3',3'-cyclic GMP-AMP binding", "definition": "Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages. [PMID:30787435]"}
{"concept_id": "C5672971", "aliases": ["3',2'-cGAMP binding", "3',2'-cyclic GAMP binding", "3',2' cyclic-GMP-AMP binding"], "types": ["T044"], "canonical_name": "3',2'-cyclic GMP-AMP binding", "definition": "Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages. [PMID:34261127]"}
{"concept_id": "C5672972", "aliases": [], "types": ["T043"], "canonical_name": "protein-containing complex localization to centriolar satellite", "definition": "A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite. [PMID:27979967]"}
{"concept_id": "C5672973", "aliases": [], "types": ["T045"], "canonical_name": "chromatin-nuclear membrane anchor activity", "definition": "Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis. [PMID:24184107]"}
{"concept_id": "C5672974", "aliases": [], "types": ["T045"], "canonical_name": "CAT tailing", "definition": "The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control sytem. [PMID:25554787, PMID:32934225]"}
{"concept_id": "C5672975", "aliases": [], "types": ["T040"], "canonical_name": "entry into host through the stromata", "definition": "Entry of a symbiont into host plant tissue via the stromata, microscopic pores in the epidermis of the aerial parts of terrestrial plants. These pores are essential for photosynthesis, as they allow CO(2) to diffuse into the plant. The host is defined as the larger of the organisms involved in a symbiotic interaction. [PMID:16959560, PMID:17419713, PMID:29307013]"}
{"concept_id": "C5672976", "aliases": ["fHC assembly"], "types": ["T045"], "canonical_name": "facultative heterochromatin assembly", "definition": "The assembly of facultative heterochromatin, heterochromatin that can be converted to euchromatin and allow transcription under specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression). [PMID:17936700]"}
{"concept_id": "C5672977", "aliases": [], "types": ["T045"], "canonical_name": "constitutive heterochromatin assembly", "definition": "The assembly of constitutive heterochromatin, heterochromatin that is always in a conformation refactory to transcription. [PMID:17936700]"}
{"concept_id": "C5672978", "aliases": [], "types": ["T044"], "canonical_name": "nuclease inhibitor activity", "definition": "Binds to and modulates the activity of a nuclease. [PMID:28785032, PMID:29554913, PMID:30046034]"}
{"concept_id": "C5672979", "aliases": ["positive regulation of patulin anabolism", "positive regulation of patulin synthesis", "positive regulation of patulin formation"], "types": ["T044"], "canonical_name": "positive regulation of patulin biosynthetic process", "definition": "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of patulin. [PMID:25625822]"}
{"concept_id": "C5672980", "aliases": ["free heme detoxification"], "types": ["T040"], "canonical_name": "detoxification of free heme", "definition": "Any process that reduces or removes the toxicity of free heme. These include transport of heme away from sensitive areas and to compartments or complexes whose purpose is sequestration of heme. [PMID:26741528, PMID:32983129]"}
{"concept_id": "C5672981", "aliases": ["siRNA dependent pericentric heterochromatin assembly"], "types": ["T045"], "canonical_name": "siRNA-dependent pericentric heterochromatin assembly", "definition": "The assembly of pericentric heterochromatin by a process mediated by a small interfering RNA. [PMID:15289661]"}
{"concept_id": "C5672982", "aliases": ["GC box binding"], "types": ["T045"], "canonical_name": "GC-box binding", "definition": "Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site. [PMID:14701757]"}
{"concept_id": "C5672983", "aliases": ["self-resistance to bioactive secondary metabolite", "self-resistance to endogenously produced compound", "self-resistance to endogenously produced toxin", "prevention of self-toxicity"], "types": ["T040"], "canonical_name": "self-resistance to endogenously produced metabolite", "definition": "A process that reduces or removes the toxicity of an endogenously produced substance. Mechanisms of resistance to endogenously produced compounds include modification the compound, export, sequestration, or mutations in the target enzyme. [PMID:21923907, PMID:29763292]"}
{"concept_id": "C5672984", "aliases": [], "types": ["T044"], "canonical_name": "tRNA ligase activator activity", "definition": "Binds to and increases the activity of a tRNA ligase, an enzyme that catalyzes the formation of aminoacyl-tRNA. [PMID:30943413]"}
{"concept_id": "C5672985", "aliases": [], "types": ["T039"], "canonical_name": "ammonium excretion", "definition": "The elimination of ammonium ions from an excretory cell. [PMID:25740900]"}
{"concept_id": "C5672986", "aliases": ["mevacor synthesis", "mevacor formation", "lovastatin anabolism", "monacolin K formation", "lovastatin biosynthesis", "lovastatin formation", "mevacor biosynthesis", "lovastatin synthesis", "mevinolin biosynthetic process", "monacolin K biosynthesis", "monacolin K anabolism", "mevacor biosynthetic process", "monacolin K synthesis", "mevinolin formation,", "mevinolin anabolism", "mevinolin biosynthesis", "mevinolin synthesis", "mevacor anabolism", "monacolin K biosynthetic process"], "types": ["T040"], "canonical_name": "lovastatin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). [PMID:10334994, PMID:10381407]"}
{"concept_id": "C5672987", "aliases": ["positive regulation of monacolin K biosynthetic process", "positive regulation of mevinolin biosynthetic process", "positive regulation of mevacor biosynthetic process"], "types": ["T044"], "canonical_name": "positive regulation of lovastatin biosynthetic process", "definition": "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of lovastin. [PMID:10334994, PMID:19781329]"}
{"concept_id": "C5672988", "aliases": [], "types": ["T026"], "canonical_name": "encapsulin nanocompartment", "definition": "Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla. [PMID:32918485]"}
{"concept_id": "C5672989", "aliases": [], "types": ["T044"], "canonical_name": "NLRP6 inflammasome complex assembly", "definition": "The aggregation, arrangement and bonding together of a set of components to form a NLRP6 inflammasome complex. [PMID:30674671, PMID:34678144]"}
{"concept_id": "C5672990", "aliases": [], "types": ["T044"], "canonical_name": "ADP-riboxanase activity", "definition": "Catalysis of the reaction: L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide. [PMID:34671164, RHEA:69500]"}
{"concept_id": "C5672991", "aliases": ["tRNA uracil 4-sulfurtransferase", "tRNA uracil 4 sulfurtransferase"], "types": ["T044"], "canonical_name": "tRNA U4 sulfurtransferase", "definition": "Catalyzes the reaction: ATP + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster <=> AMP + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster. [PMID:27791189, PMID:5541999, RHEA:24176]"}
{"concept_id": "C5672992", "aliases": [], "types": ["T045"], "canonical_name": "lncRNA transcription", "definition": "The transcription of lncRNAs, non-coding RNAs over 200 nucleotides in length, from a DNA template. [PMID:33767452, PMID:33913806]"}
{"concept_id": "C5672993", "aliases": [], "types": ["T045"], "canonical_name": "regulation of lncRNA transcription", "definition": "Any process that modulates the frequency, rate or extent of the synthesis of a lncRNA. [PMID:33767452, PMID:33913806]"}
{"concept_id": "C5672994", "aliases": [], "types": ["T045"], "canonical_name": "negative regulation of lncRNA transcription", "definition": "Any process that decreases the frequency, rate or extent of the synthesis of a lncRNA. [PMID:33767452, PMID:33913806]"}
{"concept_id": "C5672995", "aliases": [], "types": ["T045"], "canonical_name": "siRNA transcription", "definition": "The transcription of a small interfering RNA from an RNA template. [PMID:23001036]"}
{"concept_id": "C5672996", "aliases": [], "types": ["T045"], "canonical_name": "siRNA catabolic process", "definition": "The chemical reactions and pathways resulting in the breakdown of small interfering RNA transcripts (siRNAs). [PMID:25928405]"}
{"concept_id": "C5672997", "aliases": [], "types": ["T045"], "canonical_name": "regulation of ncRNA transcription", "definition": "Any process that modulates the frequency, rate or extent of transcription of a non-protein coding gene from a DNA-template. [GOC:pg]"}
{"concept_id": "C5672998", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process", "definition": "Any process that activates or increases the frequency, rate or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process. [PMID:19189958]"}
{"concept_id": "C5672999", "aliases": [], "types": ["T044"], "canonical_name": "phlorizin hydrolase activity", "definition": "Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin. [PMID:9762914]"}
{"concept_id": "C5673000", "aliases": ["nucleosome array spacing activity"], "types": ["T044"], "canonical_name": "nucleosome array spacer activity", "definition": "A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair. [PMID:11683384, PMID:16468993]"}
{"concept_id": "C5673001", "aliases": ["histone octamer sliding activity"], "types": ["T044"], "canonical_name": "histone octamer slider activity", "definition": "A chromatin remodeler activity that slides core histone octamers along chromosomal DNA. [PMID:10466730]"}
{"concept_id": "C5673002", "aliases": [], "types": ["T044"], "canonical_name": "branched 1,3-beta-D-glucan synthase activity", "definition": "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a branched [(1->3)-beta-D-glucosyl](n+1). [PMID:34959732]"}
{"concept_id": "C5673003", "aliases": [], "types": ["T044"], "canonical_name": "linear 1,3-beta-D-glucan synthase activity", "definition": "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a linear [(1->3)-beta-D-glucosyl](n+1). [PMID:34959732]"}
{"concept_id": "C5673004", "aliases": [], "types": ["T038"], "canonical_name": "reorganization of cellular membranes to establish viral sites of replication", "definition": "A process in intracellular membranes are reorganized by viral proteins that perturb membrane integrity and can cause an extensive rearrangement of cellular membranes, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus. [PMID:19376974]"}
{"concept_id": "C5673005", "aliases": [], "types": ["T040"], "canonical_name": "reorganization of host cellular membranes to establish sites of replication", "definition": "A process in which a virus triggers host intracellular membranes to be reorganized, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus. [PMID:34699787, PMID:4372566]"}
{"concept_id": "C5673006", "aliases": [], "types": ["T044"], "canonical_name": "structural constituent of proteasome", "definition": "The action of a molecule that contributes to the structural integrity of the proteasome. [PMID:10500111, PMID:28525752, PMID:28583440, PMID:29652515]"}
{"concept_id": "C5673007", "aliases": [], "types": ["T044"], "canonical_name": "cysteine-type deNEDDylase activity", "definition": "An thiol-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. [PMID:25628956]"}
{"concept_id": "C5673008", "aliases": [], "types": ["T044"], "canonical_name": "metal-dependent deNEDDylase activity", "definition": "An metal-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. [PMID:25628956]"}
{"concept_id": "C5673009", "aliases": ["histone lysine N-methyltransferase activity (H3-K56 specific)"], "types": ["T044"], "canonical_name": "histone methyltransferase activity (H3-K56 specific)", "definition": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group onto lysine at position 56 of the histone H3 protein. [PMID:23451023, PMID:28743002]"}
{"concept_id": "C5673010", "aliases": [], "types": ["T044"], "canonical_name": "histone H3-tri/dimethyl-lysine-56 demethylase activity", "definition": "Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 56 of the histone H3 protein. [PMID:23451023, PMID:28743002]"}
{"concept_id": "C5673011", "aliases": ["calcium- and calmodulin-regulated cyclic-AMP phosphodiesterase activity", "calcium/calmodulin-regulated cAMP-specific phosphodiesterase activity", "calcium- and calmodulin-regulated AMP-specific phosphodiesterase activity"], "types": ["T044"], "canonical_name": "calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity", "definition": "Catalysis of the reactions: nucleoside 3',5'-cyclic AMP + H2O = AMP + H+; this activity is activated by binding to calcium-bound calmodulin. [PMID:15901640]"}
{"concept_id": "C5673012", "aliases": [], "types": ["T044"], "canonical_name": "glucose dehydrogenase (FAD, quinone) activity", "definition": "Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone. [RHEA:47372]"}
{"concept_id": "C5673013", "aliases": [], "types": ["T045"], "canonical_name": "programmed DNA elimination by elimination of internal DNA segments", "definition": "A programmed DNA elimination mechanism in which specific sequences, namely, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the genome. This process is known to occur in ciliates. [PMID:18708581]"}
{"concept_id": "C5673014", "aliases": [], "types": ["T045"], "canonical_name": "small RNA binding translational repressor activity", "definition": "A translational repressor activity that binds to a single-stranded small regulatory RNA (either a miRNA or a siRNA) to guide it to its target mRNA. [PMID:27184117, PMID:34117606]"}
{"concept_id": "C5673015", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent histone deacetylase activity (H3-K56 specific)", "definition": "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 56) + H2O = histone H3 L-lysine (position 56) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 56 of the histone H3 protein. [PMID:23911928, PMID:30374165]"}
{"concept_id": "C5673016", "aliases": ["gene silencing by siRNA", "posttranscriptional gene silencing by siRNA", "post-transcriptional gene silencing by siRNA", "siRNA-mediated PTGS"], "types": ["T045"], "canonical_name": "siRNA-mediated gene silencing", "definition": "A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants. [PMID:26372022]"}
{"concept_id": "C5673017", "aliases": [], "types": ["T044"], "canonical_name": "enzyme-substrate adaptor activity", "definition": "An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity. [PMID:16250895, PMID:34358446]"}
{"concept_id": "C5673018", "aliases": [], "types": ["T044"], "canonical_name": "protein ADP-ribosyltransferase-substrate adaptor activity", "definition": "An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate. [PMID:32028527]"}
{"concept_id": "C5673019", "aliases": [], "types": ["T044"], "canonical_name": "ACP-dependent peptidyl-lysine N6-myristoyltransferase activity", "definition": "Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]. [PMID:32461253]"}
{"concept_id": "C5673020", "aliases": [], "types": ["T044"], "canonical_name": "CoA-dependent peptidyl-lysine N6-myristoyltransferase activity", "definition": "Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]. [PMID:1402651, RHEA:59752]"}
{"concept_id": "C5673021", "aliases": [], "types": ["T044"], "canonical_name": "ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity", "definition": "Catalysis of the reaction: hexadecanoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]. [PMID:32461253]"}
{"concept_id": "C5673022", "aliases": [], "types": ["T044"], "canonical_name": "CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity", "definition": "Catalysis of the reaction: L-lysyl-[protein] + hexadecanoyl-CoA = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-[protein]. [PMID:30061757]"}
{"concept_id": "C5673023", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent protein demyristoylase activity", "definition": "Catalysis of the reaction: N6-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. [PMID:23552949]"}
{"concept_id": "C5673024", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent protein depalmitoylase activity", "definition": "Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. [PMID:23552949]"}
{"concept_id": "C5673025", "aliases": ["actin debranching activity"], "types": ["T044"], "canonical_name": "actin filament debranching activity", "definition": "Binding to an actin filament and promoting the dissociation of an actin filament branch. [PMID:20362448]"}
{"concept_id": "C5673026", "aliases": [], "types": ["T044"], "canonical_name": "protein-containing complex destabilizing activity", "definition": "A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex. [PMID:23727094, PMID:29779865, PMID:34836783]"}
{"concept_id": "C5673027", "aliases": [], "types": ["T044"], "canonical_name": "protein-containing complex stabilizing activity", "definition": "A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex. [PMID:34040253]"}
{"concept_id": "C5673028", "aliases": [], "types": ["T044"], "canonical_name": "microtubule stabilizing activity", "definition": "A protein-containing complex stabilizing activity that prevents dissociation of microtubules. [PMID:34970964]"}
{"concept_id": "C5673029", "aliases": ["lymphotactin production"], "types": ["T043"], "canonical_name": "XCL1 production", "definition": "The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [PMID:7973732]"}
{"concept_id": "C5673030", "aliases": ["ilicicolin H formation", "ilicicolin H biosynthesis", "ilicicolin H anabolism", "ilicicolin H synthesis"], "types": ["T044"], "canonical_name": "ilicicolin H biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of ilicicolin H, a 4-hydroxy-2-pyridone alkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain. [PMID:30905148, PMID:31216742, PMID:34947016]"}
{"concept_id": "C5673031", "aliases": ["novofumigatonin synthesis", "novofumigatonin biosynthesis", "novofumigatonin formation", "novofumigatonin anabolism"], "types": ["T044"], "canonical_name": "novofumigatonin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety. [PMID:29968715]"}
{"concept_id": "C5673032", "aliases": ["(M)-viriditoxin anabolism", "(M)-viriditoxin biosynthesis", "(M)-viriditoxin synthesis", "(M)-viriditoxin formation"], "types": ["T044"], "canonical_name": "(M)-viriditoxin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of (M)-viriditoxin, a fungal secondary metabolite with antibacterial activity. [PMID:31045362, PMID:31304040]"}
{"concept_id": "C5673033", "aliases": [], "types": ["T044"], "canonical_name": "metal ion sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion. [GOC:pg]"}
{"concept_id": "C5673034", "aliases": ["amino acid sensing activity"], "types": ["T044"], "canonical_name": "amino acid sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of an amino acid. [GOC:pg]"}
{"concept_id": "C5673035", "aliases": ["glutamine sensing activity"], "types": ["T044"], "canonical_name": "glutamine sensor activity", "definition": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of glutamine. [PMID:34535752]"}
{"concept_id": "C5673036", "aliases": [], "types": ["T044"], "canonical_name": "phosphate ion uniporter activity", "definition": "Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. [PMID:29642010]"}
{"concept_id": "C5673037", "aliases": [], "types": ["T044"], "canonical_name": "L-glutamate uniporter activity", "definition": "Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. [PMID:27133463, PMID:29642010]"}
{"concept_id": "C5673038", "aliases": [], "types": ["T044"], "canonical_name": "histone serine/threonine phosphatase activity", "definition": "Catalysis of the reaction: histone serine phosphate + H2O = histone serine + phosphate, and histone threonine phosphate + H2O = histone threonine + phosphate. [PMID:18614045]"}
{"concept_id": "C5673039", "aliases": [], "types": ["T044"], "canonical_name": "histone serine phosphatase activity (H2-S140 specific)", "definition": "Catalysis of the reaction: histone H2 serine phosphate (position 140) + H2O = histone serine (position 140) + phosphate. [PMID:18614045]"}
{"concept_id": "C5673040", "aliases": [], "types": ["T044"], "canonical_name": "histone tyrosine phosphatase activity", "definition": "Catalysis of the reaction: histone tyrosine phosphate + H2O = histone tyrosine + phosphate. [PMID:19234442, PMID:19351884]"}
{"concept_id": "C5673041", "aliases": [], "types": ["T044"], "canonical_name": "histone tyrosine phosphatase activity (H2-Y142 specific)", "definition": "Catalysis of the reaction: histone H2 tyrosine phosphate (position 142) + H2O = histone tyrosine (position 142) + phosphate. [PMID:19234442, PMID:19351884]"}
{"concept_id": "C5673042", "aliases": [], "types": ["T044"], "canonical_name": "histone-arginine deiminase activity", "definition": "Catalysis of the reaction: H2O + histone 3 L-arginyl = histone 3 L-citrullyl + NH4+, resulting in histone citrullination. [PMID:15339660]"}
{"concept_id": "C5673043", "aliases": ["H3-R2 citrullination"], "types": ["T044"], "canonical_name": "histone-arginine deiminase activity (H3-R2 specific)", "definition": "Catalysis of the reaction: H2O + histone 3 L-arginyl (position 2)= histone 3 L-citrullyl (position 2) + NH4+, resulting in histone H3 citrullination at position 2. [PMID:15339660]"}
{"concept_id": "C5673044", "aliases": ["H3-R8 citrullination"], "types": ["T044"], "canonical_name": "histone-arginine deiminase activity (H3-R8 specific)", "definition": "Catalysis of the reaction: H2O + histone 3 L-arginyl (position 8)= histone 3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8. [PMID:15339660]"}
{"concept_id": "C5673045", "aliases": ["H3-R17 citrullination"], "types": ["T044"], "canonical_name": "histone-arginine deiminase activity (H3-R17 specific)", "definition": "Catalysis of the reaction: H2O + histone 3 L-arginyl (position 17)= histone 3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17. [PMID:15339660]"}
{"concept_id": "C5673046", "aliases": [], "types": ["T044"], "canonical_name": "glycine:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out). [PMID:16701208, PMID:26912364]"}
{"concept_id": "C5673047", "aliases": [], "types": ["T044"], "canonical_name": "gamma-aminobutyric acid:proton antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + n H+(in) = 4-aminobutanoate(in) + n H+(out). [PMID:16701208, PMID:26912364, PMID:27601664]"}
{"concept_id": "C5673048", "aliases": [], "types": ["T044"], "canonical_name": "histone kinase activity (H2A-Y142 specific)", "definition": "Catalysis of the transfer of a phosphate group to the tyrosine-142 residue of the C-terminal tail of histone H2A. [PMID:19092802]"}
{"concept_id": "C5673049", "aliases": [], "types": ["T044"], "canonical_name": "NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: [protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide. [PMID:28525742, RHEA:58268]"}
{"concept_id": "C5673050", "aliases": [], "types": ["T044"], "canonical_name": "NAD+- protein-cysteine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]. [PMID:25043379, RHEA:56612]"}
{"concept_id": "C5673051", "aliases": [], "types": ["T044"], "canonical_name": "NAD+- protein-lysine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide. [PMID:25043379, RHEA:58220]"}
{"concept_id": "C5673052", "aliases": [], "types": ["T044"], "canonical_name": "NAD+-protein-serine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. [PMID:32028527, PMID:33186521, RHEA:58232]"}
{"concept_id": "C5673053", "aliases": [], "types": ["T044"], "canonical_name": "NAD+- protein-aspartate ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide. [PMID:19764761, PMID:25043379, RHEA:54424]"}
{"concept_id": "C5673054", "aliases": [], "types": ["T044"], "canonical_name": "NAD+-protein-glutamate ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide. [PMID:19764761, PMID:25043379, RHEA:58224]"}
{"concept_id": "C5673055", "aliases": [], "types": ["T044"], "canonical_name": "NAD+-protein-tyrosine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]. [PMID:29954836, PMID:30257210, RHEA:58236]"}
{"concept_id": "C5673056", "aliases": ["H4-R3 citrullination"], "types": ["T044"], "canonical_name": "histone-arginine deiminase activity (H4-R3 specific)", "definition": "Catalysis of the reaction: H2O + histone 4 L-arginyl (position 3)= histone 4 L-citrullyl (position 3) + NH4+, resulting in histone H3 citrullination at position 3. [PMID:16567635]"}
{"concept_id": "C5673057", "aliases": ["H1-R54 citrullination"], "types": ["T044"], "canonical_name": "histone-arginine deiminase activity (H1-R54 specific)", "definition": "Catalysis of the reaction: H2O + histone 1 L-arginyl (position 54)= histone 1 L-citrullyl (position 54) + NH4+, resulting in histone H1 citrullination at position 54. [PMID:24463520]"}
{"concept_id": "C5673058", "aliases": ["H2A-R3 citrullination"], "types": ["T044"], "canonical_name": "histone-arginine deiminase activity (H2A-R3 specific)", "definition": "Catalysis of the reaction: H2O + histone 2A L-arginyl (position 3)= histone 2A L-citrullyl (position 3) + NH4+, resulting in histone H2A citrullination at position 3. [PMID:15823041]"}
{"concept_id": "C5673059", "aliases": [], "types": ["T044"], "canonical_name": "orotate:anion antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: orotate(out) + anion (in) = orotate (in) + anion (out). [PMID:21350910, PMID:35144162]"}
{"concept_id": "C5673060", "aliases": [], "types": ["T044"], "canonical_name": "urate:anion antiporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out). [PMID:12024214, PMID:18411268]"}
{"concept_id": "C5673061", "aliases": [], "types": ["T044"], "canonical_name": "glycine betaine:sodium:chloride symporter activity", "definition": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in). [PMID:10358010]"}
{"concept_id": "C5673062", "aliases": [], "types": ["T044"], "canonical_name": "NAD+-protein-histidine ADP-ribosyltransferase activity", "definition": "Catalysis of the reaction: L-histidyl-[protein] + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide. [PMID:35393539]"}
{"concept_id": "C5673063", "aliases": [], "types": ["T044"], "canonical_name": "NAD+-histone-serine ADP-ribosyltransferase activity (H2B-S6 specific)", "definition": "Catalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B. [PMID:34874266]"}
{"concept_id": "C5673064", "aliases": [], "types": ["T044"], "canonical_name": "NAD+-histone-serine ADP-ribosyltransferase activity (H3-S10 specific)", "definition": "Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3. [PMID:34874266]"}
{"concept_id": "C5673065", "aliases": ["mRNA 5'-triphosphate monophosphatase activity"], "types": ["T044"], "canonical_name": "mRNA 5'-phosphatase activity", "definition": "A 5'-end triphospho-[mRNA] + H(2)O = a 5'-end diphospho-[mRNA] + H+ + phosphate. [PMID:9473487]"}
{"concept_id": "C5673066", "aliases": [], "types": ["T044"], "canonical_name": "UDP-beta-L-arabinofuranose transporter activity", "definition": "Enables the transfer of UDP-beta-L-arabinofuranose from one side of a membrane to the other. [PMID:28373556]"}
{"concept_id": "C5673067", "aliases": [], "types": ["T043"], "canonical_name": "cytosol to Golgi apparatus transport", "definition": "The directed movement of substances from the cytosol into the Golgi apparatus of a cell. [PMID:28373556]"}
{"concept_id": "C5673068", "aliases": ["cytosol to Golgi apparatus UDP-beta-L-arabinofuranose transport"], "types": ["T043"], "canonical_name": "UDP-beta-L-arabinofuranose import into Golgi lumen", "definition": "The directed movement of UDP-beta-L-arabinofuranose from the cytosol to the Golgi apparatus of a cell. [PMID:28373556]"}
{"concept_id": "C5673069", "aliases": [], "types": ["T044"], "canonical_name": "ADP-D-ribose modification-dependent protein binding", "definition": "Binding to a protein upon ADP-ribosylation of the target protein. [PMID:26673700]"}
{"concept_id": "C5673070", "aliases": [], "types": ["T044"], "canonical_name": "mono-ADP-D-ribose modification-dependent protein binding", "definition": "Binding to a protein upon mono-ADP-ribosylation of the target protein. [PMID:34023495]"}
{"concept_id": "C5673071", "aliases": [], "types": ["T044"], "canonical_name": "poly-ADP-D-ribose modification-dependent protein binding", "definition": "Binding to a protein upon poly-ADP-ribosylation of the target protein. [PMID:26673700]"}
{"concept_id": "C5673072", "aliases": ["Ig-complexed antigen endocytosis via Fc receptor", "antigen-antibody immune complex uptake via Fc receptor"], "types": ["T043"], "canonical_name": "Fc receptor-mediated immune complex endocytosis", "definition": "An endocytosis process mediated by the Fc receptor for the purpose of delivery of antigen-bound immunoglobulin to an intracellular compartment where the antigen can be processed and loaded onto MHC molecules. This process selectively targets antigens for presentation by MHC class II or cross-presentation by MHC class I. [PMID:28389502, PMID:9143687, PMID:9463401]"}
{"concept_id": "C5673073", "aliases": [], "types": ["T043"], "canonical_name": "glutathione import into mitochondrion", "definition": "The process in which glutathione is transported from the cytosol into the mitochondrial matrix. [PMID:34707288]"}
{"concept_id": "C5673074", "aliases": [], "types": ["T044"], "canonical_name": "protein decrotonylase activity", "definition": "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]. [PMID:28497810, PMID:30279482, PMID:34608293]"}
{"concept_id": "C5673075", "aliases": [], "types": ["T044"], "canonical_name": "histone decrotonylase activity", "definition": "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]. [PMID:28497810]"}
{"concept_id": "C5673076", "aliases": [], "types": ["T044"], "canonical_name": "protein de-2-hydroxyisobutyrylase activity", "definition": "Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]. [PMID:29192674]"}
{"concept_id": "C5673077", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent protein decrotonylase activity", "definition": "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. [PMID:28497810]"}
{"concept_id": "C5673078", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent histone decrotonylase activity", "definition": "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide. [PMID:28497810]"}
{"concept_id": "C5673079", "aliases": [], "types": ["T044"], "canonical_name": "NAD-dependent protein de-2-hydroxyisobutyrylase activity", "definition": "Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. [PMID:31328167]"}
{"concept_id": "C5673080", "aliases": [], "types": ["T026"], "canonical_name": "exopher", "definition": "An extracellular vesicle that is approximately four microns in diameter, released by budding out of cells into the extracellular space, and hypothesized to be a mechanism for disposal of unwanted cellular material including protein aggregates and damaged organelles. [PMID:28178240, PMID:33016946, PMID:33027673, PMID:33659873, PMID:34288362, PMID:34475208]"}
{"concept_id": "C5673081", "aliases": [], "types": ["T043"], "canonical_name": "platelet rolling", "definition": "Transient adhesive interactions between platelets and endothelial cells lining blood vessels. Carbohydrates on circulating platelets bind selectins or other molecules on the vessel wall causing the platelets to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between surface molecules of platelets and endothelium. [GOC:sl, PMID:29018081]"}
{"concept_id": "C5673082", "aliases": [], "types": ["T043"], "canonical_name": "regulation of platelet rolling", "definition": "Any process that modulates the frequency, rate or extent of platelet rolling. [GO_REF:0000058, GOC:sl]"}
{"concept_id": "C5673083", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of platelet rolling", "definition": "Any process that increases the rate, frequency, or extent of platelet rolling. [GO_REF:0000058, GOC:sl]"}
{"concept_id": "C5673084", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of platelet rolling", "definition": "Any process that decreases the rate, frequency, or extent of platelet rolling. [GO_REF:0000058, GOC:sl, PMID:15738422]"}
{"concept_id": "C5673085", "aliases": [], "types": ["T043"], "canonical_name": "positive regulation of ferroptosis", "definition": "Any process that activates or increases the frequency, rate or extent of ferroptosis. [PMID:32015325]"}
{"concept_id": "C5673086", "aliases": [], "types": ["T043"], "canonical_name": "apocrine secretion", "definition": "The controlled release of a substance by a cell or a tissue by discharging a portion of the secreting cell when intracellular components are freed into a lumen through the shedding of whole pieces of the cytoplasm. [PMID:25960390]"}
{"concept_id": "C5673087", "aliases": ["sternutation"], "types": ["T042"], "canonical_name": "sneeze reflex", "definition": "A reflex process that expels air forcibly from the mouth and nose in an explosive, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane. [https://www.thefreedictionary.com/sneeze, PMID:34133943]"}
{"concept_id": "C5673088", "aliases": [], "types": ["T043"], "canonical_name": "Leydig cell proliferation", "definition": "The multiplication or reproduction of Leydig cells, resulting in the expansion of a cell population. Leydig cells are interstitial cells located adjacent to the seminiferous tubules in the testis which produce testosterone. [PMID:29632025]"}
{"concept_id": "C5673089", "aliases": [], "types": ["T043"], "canonical_name": "negative regulation of pyroptosis", "definition": "Any process that decreases the frequency, rate or extent of pyroptosis. [PMID:34637033]"}
{"concept_id": "C5673090", "aliases": [], "types": ["T043"], "canonical_name": "kidney cortex tubule cell dedifferentiation", "definition": "The process in which a kidney cortex tubule cell (specialized epithelial cell of the kidney) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. [PMID:18987110, PMID:31847447]"}
{"concept_id": "C5673091", "aliases": [], "types": ["T043"], "canonical_name": "xylitol transmembrane transport", "definition": "The directed movement of a xylitol across a membrane. Xylitol is a polyalcohol (pentane-1,2,3,4,5-pentol), produced by hydrogenation of xylose. [GOC:TermGenie, PMID:23475614]"}
{"concept_id": "C5673092", "aliases": [], "types": ["T043"], "canonical_name": "L-arginine transmembrane transport", "definition": "The directed movement of L-arginine across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:18357653, PMID:22822152, PMID:8195186]"}
{"concept_id": "C5673093", "aliases": [], "types": ["T044"], "canonical_name": "mRNA N1-methyladenosine dioxygenase activity", "definition": "Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde. [PMID:26863196, PMID:26863410]"}
{"concept_id": "C5673094", "aliases": [], "types": ["T043"], "canonical_name": "oxytocin production", "definition": "The appearance of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG, due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior. It also acts as a neurotransmitter in the brain. [GOC:cjm, Wikipedia:Oxytocin]"}
{"concept_id": "C5673095", "aliases": ["patulin formation", "patulin synthesis", "patulin anabolism", "patulin biosynthesis"], "types": ["T044"], "canonical_name": "patulin biosynthetic process", "definition": "The chemical reactions and pathways resulting in the formation of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. [PMID:25120234, PMID:30680886]"}
{"concept_id": "C5673096", "aliases": [], "types": ["T044"], "canonical_name": "histone phosphatase activity", "definition": "Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate. [PMID:19351884]"}
{"concept_id": "C5673097", "aliases": [], "types": ["T042"], "canonical_name": "renal urate salt excretion", "definition": "The elimination of urate salt or uric acid from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. [GOC:jl, PMID:25287933, PMID:3906799, Wikipedia:Renal_physiology#Secretion]"}
{"concept_id": "C5673098", "aliases": ["mRNA N(6)-methyladenosine dioxygenase activity", "mRNA N(6)-methyladenine demethylase"], "types": ["T044"], "canonical_name": "mRNA N6-methyladenosine dioxygenase activity", "definition": "Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde. [PMID:22002720, PMID:26458103]"}